CAMKK2 PATHWAY%WIKIPATHWAYS_20260710%WP4874%HOMO SAPIENS CAMKK2 pathway HMOX1 SLC25A21 NLRP1 SLC38A5 PCK2 MAPK3 ABCA1 FIS1 VCAM1 WFS1 MX2 TMEM176B NFATC2 ASNS GCK EPOR MTOR KLF1 CXCL11 RPS6KB1 SELL SLCO3A1 TRPV4 CAMK4 FASN SPIRE1 RHAG CAMK1 CALM1 NFE2L2 CHRM3 CRTC2 MS4A3 HFE KEAP1 CPOX SLC2A4 TNF IFGGE HK2 AQP1 OASL RPTOR MAP1LC3A CCND1 KDR EP300 RAC1 ERMAP GALNT9 RPS6 MAMDC2 TSC1 ATP1B2 SMC1A WDR35 SIRT1 MID1 ERAF MAF CREB1 STIM1 SPINT1 CCNE1 C1QTNF12 HMBS DKFZp762B153 FAM20C ULK1 RAF1 ARHGEF7 SFI1 SQSTM1 S100A8 PFKFB2 DGIC ATP10D TBXT TSPAN33 HIF1A RELA ACACA RHD CAMKK2 ENHO PAK1 CYB5R3 TSPAN8 CCL5 MAPK1 PHOTODYNAMIC THERAPY INDUCED AP 1 SURVIVAL SIGNALING%WIKIPATHWAYS_20260710%WP3611%HOMO SAPIENS Photodynamic therapy induced AP 1 survival signaling BCL2 BAX BCL2L1 HBEGF TNF CCND1 NFE2L2 RB1 ATF2 CDKN1A EGFR MAPK8 FGF7 BCL2L11 TNFSF10 CCNE1 BMF BAK1 JUNB MAP3K5 MCL1 MAP2K6 MAP2K3 MAP2K4 PDGFRA JUN CDKN2A MMP2 TRAF2 FOS MAPK14 MAPK12 IL2 TNFRSF1A MAPK13 CCNA2 MAPK11 IL6 TNFSF6 IFNG TRAF6 TRAF5 MONOAMINE TRANSPORT AND REGULATION%WIKIPATHWAYS_20260710%WP727%HOMO SAPIENS Monoamine transport and regulation ACHE TPH2 TGFB1I1 ITGB3 TNFRSF11B DBH SLC6A2 TNF SLC6A3 HRH3 TDO2 UNC13B IL1R1 TSC2 FBXO32 SYN1 RBL2 SLC5A7 ADORA2A TH IL1B AMPH STX1A NECTIN2 MAPK14 CHOLESTASIS%WIKIPATHWAYS_20260710%WP5238%HOMO SAPIENS Cholestasis ATP8B1 ABCB4 NR1I3 EPHX1 SLC22A1 NR1H4 HMGCR ABCB11 RXRA SLCO1A2 LDLR ABCC3 SCARB1 ABCG8 ABCG5 ABCC2 CONTROL OF IMMUNE TOLERANCE BY VASOACTIVE INTESTINAL PEPTIDE%WIKIPATHWAYS_20260710%WP4484%HOMO SAPIENS Control of immune tolerance by vasoactive intestinal peptide CTLA4 IL12A VIP IL2 IL10 IL4 IL5 IFNG TGFB1 CD80 PATHOGENIC ESCHERICHIA COLI INFECTION%WIKIPATHWAYS_20260710%WP2272%HOMO SAPIENS Pathogenic Escherichia coli infection TUBA3E TUBA1C TUBB6 TUBA1B TUBA1A YWHAQ PS1TP5BP1 TUBB1 NCK2 FYN CD14 NCK1 TUBB PRKCA ARPC4 ARPC5 HEL-68 TUBB4B TUBB4A TUBA4A TUBB2A KRT18 ARHA ARPC2 ARPC3 TUBA2 NCL HCLS1 ARHGEF2 TLR5 EZR TLR4 TUBA8 ITGB1 HEL-S-93 ROCK1 TUBAL3 ROCK2 ARPC1B WAS LY96 WASL CLDN1 ACTG1 TUBB8 CDC42 SARS COV 2 AND COVID 19 PATHWAY%WIKIPATHWAYS_20260710%WP4846%HOMO SAPIENS SARS CoV 2 and COVID 19 pathway ACE2 NRP1 SLC6A19 CTSL TMPRSS4 TMPRSS2 FURIN TLR7 ACAT1 SCARB1 MITOCHONDRIAL CARRIER DEFICIENCY ASSOCIATED WITH SHUTTLE DISTURBANCES%WIKIPATHWAYS_20260710%WP5507%HOMO SAPIENS Mitochondrial carrier deficiency associated with shuttle disturbances GLUD1 GOT2 SLC25A12 SLC25A22 SLC25A13 METAPATHWAY BIOTRANSFORMATION PHASE I AND II%WIKIPATHWAYS_20260710%WP702%HOMO SAPIENS Metapathway biotransformation Phase I and II UGT1A10 TPMT HEL-S-75 Em:AP000351.3 CYP46A1 HS6ST1 HS6ST2 HS6ST3 CYP4Z1 NDST3 CYP1B1 SULT2A1 HEL-S-64p HEL-S-166mP UGT2B11 UGT2B15 UGT2B17 SULT2B1 CYP27A1 CYP2U1 CYP2E1 SULT6B1 NNMT HS3ST3A1 MGST3 MGST1 GSTT2 MGST2 CYP2C19 CYP4F22 CYP2C18 SULT1A1 CYP27B1 CYP2B6 CYP4X1 CHST11 CHST12 CYP11A1 CHST10 CHST13 CHST14 SULT1A4 SULT1A2 NAA50 CYP2J2 GSTM4 GATF-C GSTM3 GSTM2 GLYATL2 GSTM1 HEL-S-165mP EPHX2 CYP4F2 CYP4F3 CYP4F11 CYP4F8 CYP4F12 SULT1B1 CYP26A1 CYP2C9 CYP27C1 AKR1B10 NAT8 CYP11B2 NAT2 CYP2S1 CYP1A2 CYP1A1 NAT9 GSTM5 NAA40 NAT10 AKR1B1 NAT14 LOC51064 HS2ST1 SULT1C3 SULT1C2 CYP26B1 CYP4V2 HYAL3 CYP2R1 UGT2A2 UGT2A1 GAL3ST2 GAL3ST3 GAL3ST4 SULT1C4 CHST8 HS3ST3B1 CHST9 GPX2 CHST6 CHST7 GPX4 UGT1A1 HEL-S-21 GPX3 CYP3A43 KCNAB1 HEL-S-22 KCNAB3 BAAT CYP7B1 INMT HEL-75 CYP2A7 CYP2A6 CYP26C1 CYP21A2 UGT2B4 CHST1 CHST4 NAT8L CHST5 UGT2B7 CHST3 HEL-S-75p NAA20 AKR1D1 UGT2B28 CYP3A4 CYP7A1 CYP17A1 CYP3A7 SULT1E1 CYP2A13 UGT1A5 UGT1A4 UGT1A3 UGT1A9 CYP2F1 UGT1A7 AKR1C1 CYP51A1 AKR1C2 HS3ST5 AKR1C4 HS3ST6 FMO4 HS3ST4 CYP8B1 FMO5 HS3ST1 HS3ST2 GSTZ1 CYP2W1 GSTA5 CYP24A1 GSTA4 GSTA3 CYP20A1 EPHX1 INTEGRIN MEDIATED CELL ADHESION%WIKIPATHWAYS_20260710%WP185%HOMO SAPIENS Integrin mediated cell adhesion CAV2 MAPK10 CAPN11 CAPN10 ZYX GRB2 FYN MAP2K6 MAP2K3 MAPK12 ITGB3 MYLK2 ITGAM ITGB4 ITGA2B ARAF HEL114 ITGAE MYPN CAPN9 CAPN6 CAPN7 AKT3 CAPN5 ITGAX RAC1 ITGB8 CAPN3 RAC3 ITGAV ITGB7 ITGB6 HRAS TNS1 VAV3 MAP2K1 MAP2K2 ITGA4 PDPK1 ITGA2 ITGA1 HEL-S-28 VAV2 SELENOP RAPGEF1 ITGA7 ITGA6 SOS1 RAF1 ARHGEF7 TLN1 CRK DOCK1 SHC3 SHC1 SRC PXN ITGB1 PIK3R2 RAP1A ROCK1 MAPK7 RHO ROCK2 PAK6 CSK MAPK6 MAPK4 PAK1 MAP2K5 PAK4 VASP GIT2 CDC42 MAPK1 CAV3 KETOGENESIS AND KETOLYSIS%WIKIPATHWAYS_20260710%WP4742%HOMO SAPIENS Ketogenesis and ketolysis CPT2 BDH1 OXCT1 UCP2 ACAT1 SLC25A20 METABOLIC EPILEPTIC DISORDERS%WIKIPATHWAYS_20260710%WP5355%HOMO SAPIENS Metabolic epileptic disorders SLC25A1 MOCS2 MOCS3 HEL-S-32 GCK GLDC HEL-S-30 SLC2A2 GPT SLC2A3 ENO1 ENO2 ENO3 GPHN DHTKD1 HK3 MPC1 MPC2 PHGDH DLAT HEL-S-162eP AASS PSPH ARG1 HEL-S-20 PGAM1 PGAM2 AMT HEL-S-68p SLC25A15 BTD ETHE1 ACAT1 ALDOB GLUD1 SLC25A5 GOT2 ALDH7A1 DLD FBP1 MOCS1 FBP2 GCDH HEL-S-87p ECHS1 GLS2 SHMT1 HEL-S-51e SLC7A2 CBS HLCS ASL PCK1 XDH PDHA1 PKLR MDH2 AADAT SQOR HEL-S-133P HEL-S-281 SUOX G6PC1 ASS1 HEL-S-49 PFKL SPCS1 SLC2A4 PC PSAT1 CTH HK2 SFXN1 CDO1 PFKM PFKP HEL60 OTC SYNAPTIC SIGNALING ASSOCIATED WITH AUTISM SPECTRUM DISORDER%WIKIPATHWAYS_20260710%WP4539%HOMO SAPIENS Synaptic signaling associated with autism spectrum disorder MAPK3 RPTOR TSC2 MTOR GSK3B AKT3 RPS6KB1 PRKAA1 PRKAA2 PTEN PRKAG1 CAMK4 PIK3CD PIK3R3 PRKAG2 TSC1 UBE3A CACNA1C HRAS PIK3R1 PRKAG3 NRAS SYNGAP1 EIF4EBP1 NTRK2 PRKAB2 HOMER1 BDNF GRIN2B PRKAB1 GRIN1 ARC GRIN3B GRIN3A PIK3CA RHEB DLG4 NF1 SHANK3 PIK3R2 MAPK1 TRANSCRIPTION ACTIVATION RNA POLYMERASE I AND KAT2A B AND INHIBITION NURD COMPLEX %WIKIPATHWAYS_20260710%WP5565%HOMO SAPIENS Transcription activation RNA polymerase I and KAT2A B and inhibition NuRD complex TBP H2AC6 SIRT7 H2BC17 H2BC12 KAT2B MAPK3 H2BC13 KAT2A H2AJ H2BC14 H2BC15 POLR1A HAT1 H2BC11 POLR1C POLR1D HIST1H2BE ASF1A ASF1B HDAC2 RRN3 SRCAP HDAC1 TAF1D H3C15 RBBP4 TAF1B EP400 MTA2 H2BC9 H2AZ1 MBD3 H2AZ2 CREBBP H4C9 H2BC8 TAF12 H3F3B HIST1H4L H2BC3 MBD2 H2BC1 GATAD2B GATAD2A H2AC20 CDK2AP1 EP300 H2AX PWWP2B H2AC19 H2AB1 CHD4 CHD3 H2AC14 H2BC26 H2BC12L H2BC21 TLK2 UBTF PWWP2A HIST1H2AB H3C8 DNA DAMAGE RESPONSE ONLY ATM DEPENDENT %WIKIPATHWAYS_20260710%WP710%HOMO SAPIENS DNA damage response only ATM dependent MAPK10 PCK2 GRB2 ARHA CDKN1A MAPK8 BCL2L11 BAK1 WNT2B CDKN1B JUN IRS1 CDKN2A PIK3C2G HMGB1 BBC3 PIK3C2B FRAT1 CCND3 CCND2 PPP2R5E MYC FOXO3A MAP3K7 WNT5B TNFSF6 AXIN1 PPP2R5C WNT16 SOS2 BCL2 LEF1 BAX PIK3R4 PIK3R5 MAPK9 ERBB2 G6PC1 DVL1 DVL2 DVL3 PMAIP1 WNT1 WNT3 WNT4 WNT10B TCF7L2 WNT10A TCF7L1 SMAD4 CCND1 MAP3K1 GSK3B AKT3 RBL2 MLKL BIK RAC1 BAD PTEN WNT3A WNT7B PIK3CD RAC3 INSR PIK3R3 WNT7A NFKB1 NFKB2 HRAS FOSL1 PIK3R1 APC BCL6 NRAS CCNG2 MDM2 ATM TP73 LDLR SOS1 PIK3CA TGFB1 SHC1 PIK3R2 CDC42 MAPK1 ESTROGEN SIGNALING%WIKIPATHWAYS_20260710%WP712%HOMO SAPIENS Estrogen signaling BCL2 CREB1 CHUK GNGT1 MAPK9 IKBKB SP1 GPER GNB1 GNAS IKBKG PIK3CA JUN FOS MAPK14 NFKB1 MAP2K1 MAPK1 ONE CARBON METABOLISM%WIKIPATHWAYS_20260710%WP241%HOMO SAPIENS One carbon metabolism AMT MTFMT AHCYL2 MTRR HEL-S-70p HEL-S-61p GLRX MTR MTHFS MAT1A TYMS SHMT1 FTCD HEL-S-51e DHFR FOLH1 MTHFD1L MTHFD1 TCN2 MTHFD2 CHDH DNMT3B AMINO ACID METABOLISM IN TRIPLE NEGATIVE BREAST CANCER CELLS%WIKIPATHWAYS_20260710%WP5213%HOMO SAPIENS Amino acid metabolism in triple negative breast cancer cells PSPH PSAT1 PHGDH SLC7A11 GLS SUPPRESSION OF HMGB1 MEDIATED INFLAMMATION BY THBD%WIKIPATHWAYS_20260710%WP4479%HOMO SAPIENS Suppression of HMGB1 mediated inflammation by THBD NFKBIA THBD HMGB1 AGER CHUK IKBKB RELA IKBKG NFKB1 DEREGULATING CELLULAR METABOLISM THROUGH NON GENOTOXIC CARCINOGENS%WIKIPATHWAYS_20260710%WP5571%HOMO SAPIENS Deregulating cellular metabolism through non genotoxic carcinogens GDF15 MARS1 OMA1 PHB2 FOXO1 HSPD1 SLC7A7 CLPP SESN2 LONP1 LONP2 EIF2A ATF4 IRS1 TSC2 MTOR MYC TSC1 REGULATION OF WNT B CATENIN SIGNALING BY SMALL MOLECULE COMPOUNDS%WIKIPATHWAYS_20260710%WP3664%HOMO SAPIENS Regulation of Wnt B catenin signaling by small molecule compounds LEF1 DVL2 WNT1 FZD1 CSNK1A1 TNKS GSK3B FZD7 MBOAT1 FZD8 DKK3 SFRP4 TCF4 AXIN1 APC 5Q35 COPY NUMBER VARIATION%WIKIPATHWAYS_20260710%WP5380%HOMO SAPIENS 5q35 copy number variation MAPK10 GRB2 PRR7 HK3 COX7B KIAA1191 FAF2 CLTB DDX41 TRIAP1 BRCA1 HEL-S-273 COX6A1 MAPK8 COX7C IGF1R BABAM1 H3F3B BABAM2 UIMC1 NELFB KDM6B ARL10 CYP7A1 COX8A TMED9 RNF44 UNC5A EED JUN FBXW7 SLC34A1 MYO7B ADAM10 FRS2 COX6B1 ARFGAP2 HIC2 DOK3 MYC EIF4E1B GPRIN1 CDHR2 FAM193B PFN3 DBN1 TMED10 RGS14 MAX MAGED1 PTH ABRAXAS1 MAPK9 GNAI3 USH1C CXCR4 ABHD5 BRCC3 NTN1 COX5A COX7A1 GNAI1 INPP5D LMAN2 RAB24 COX3 COX2 COX1 PLCG1 ZNF346 SNCB CAPN3 DRD2 PDLIM7 SNCA BARD1 PRELID1 PTPRN2 PIK3R1 NOP16 MUPCDH HIGD2A FGF19 TSPAN17 ANKS4B FGFR4 RNP24 MXD3 GRIN2B PNPLA2 GRIN1 SOS1 H2AX SRC DEREGULATION OF RAB AND RAB EFFECTOR GENES IN BLADDER CANCER%WIKIPATHWAYS_20260710%WP2291%HOMO SAPIENS Deregulation of Rab and Rab effector genes in bladder cancer TBC1D10A SYTL2 EXPH5 RPH3A MLPH MADD SYTL1 RAB27A RAB27B MYRIP SYTL5 UNC13D FAMILIAL HYPERLIPIDEMIA TYPE 4%WIKIPATHWAYS_20260710%WP5111%HOMO SAPIENS Familial hyperlipidemia type 4 PLTP GPIHBP1 LDLR GCK PDIA2 GCKR DGAT2 MTTP SEL1L APOA2 LPL APOA4 APOA5 LMF1 LIPC APOC2 ACSS1 MITOCHONDRIAL FATTY ACID OXIDATION DISORDERS%WIKIPATHWAYS_20260710%WP5123%HOMO SAPIENS Mitochondrial fatty acid oxidation disorders PECR ACADVL CPT1A SLC22A5 ACSL1 CPT2 FACL4 ACSL3 ACSF2 HADHB SLC25A20 ACADL EHHADH ACADM ACADS PRO SURVIVAL SIGNALING OF NEUROPROTECTIN D1%WIKIPATHWAYS_20260710%WP5182%HOMO SAPIENS Pro survival signaling of neuroprotectin D1 BAX TNF RIPK3 TRADD CASP9 TRAF2 CASP8 CASP3 CYCS RIPK1 FADD TNFRSF1A BIRC3 CLOCK CONTROLLED AUTOPHAGY IN BONE METABOLISM%WIKIPATHWAYS_20260710%WP5205%HOMO SAPIENS Clock controlled autophagy in bone metabolism MTOR BMPR2 CSF1 BHLHE41 RORB ARHGAP4 FYCO1 DKFZp686F0183 CTSK RB1CC1 LAMP2 DKFZp781O1323 TNFSF11 SOST ATG3 ATG10 DKK1 RUNX2 ATG12 CRY1 CALCA VCP NOTCH1 CTF1 SEMA3A LRP5 BHLHB2 HMGB1 TNFRSF11A AMBRA1 NPAS2 EFNB2 ATG101 DRAM2 CTHRC1 SMAD1 SEMA4D SMAD9 IL6 NR1D2 NFATC1 TRAF6 IGF1 WNT16 BMP6 BMP5 BCL2 BMP4 PER1 PTH BMP3 IL3 BMP2 ATG16L1 LEP TNFRSF11B PLEKHM1 SP7 WNT10B MAP1LC3A SMAD4 PRKAA2 DKFZp762B153 ULK1 SQSTM1 TGFB1 16P11 2 PROXIMAL DELETION SYNDROME%WIKIPATHWAYS_20260710%WP4949%HOMO SAPIENS 16p11 2 proximal deletion syndrome MAPK3 CASP8 EZR MAP2K6 MAP2K3 TRAF2 HEL-S-87p TRAF6 SMEK1 DOC2A FAM57B FIMP NR3C1 UNC13B CCT6B PAGR1 SPN PPP4R1 PPP4R2 PPP2R1A PPP4R4 PTEN HEL70 UNC13A PARP4 HEL-S-69 PPP2R5D NFKB1 PPP4R3B ASPHD1 TCP1 KCTD13 PPARG ZG16 INO80E PCNA PAXIP1 HDAC3 KMT2C MVP GDPD3 CORO1A PPP2CA HIRA HIRIP3 PPP4C CCT8 CCT7 CDIPT BPTF CCT4 IGBP1 MLL2 PRRT2 HEL-S-90n SIAH1 HEL-S-100n TBX6 C16orf54 CCT6A TAOK2 REL CCDC6 YPEL3 ALA OXYLIPIN METABOLISM%WIKIPATHWAYS_20260710%WP5136%HOMO SAPIENS ALA oxylipin metabolism ALOX15 EPHX2 ALOX5 OMEGA 3 FATTY ACIDS IN SENESCENCE%WIKIPATHWAYS_20260710%WP5432%HOMO SAPIENS Omega 3 fatty acids in senescence ALOX15 PTGIS HPGD ELOVL5 EPHX2 CYP2E1 ELOVL2 GPR32 ALOX12 FPR2 LTC4S PTGS2 CYP3A4 ALOX15B PTGS1 CYP2C9 FADS2 FADS1 PTGES CYP1A2 HEL-S-22 GSTM4 ALOX5 GANGLIO SPHINGOLIPID METABOLISM%WIKIPATHWAYS_20260710%WP1423%HOMO SAPIENS Ganglio sphingolipid metabolism SLC33A1 B3GALT1 B3GALT4 ST8SIA5 ST3GAL5 B4GALNT1 FUT1 A3GALT2 ST3GAL1 ST6GALNAC6 ST8SIA1 SEROTONIN HTR1 GROUP AND FOS PATHWAY%WIKIPATHWAYS_20260710%WP722%HOMO SAPIENS Serotonin HTR1 group and FOS pathway GNAI3 MAPK3 GNAI1 MAP3K1 ARHA RASGRF1 HTR2A RPS6KA5 HTR1E HTR1F MAP2K1 STAT3 MAP2K2 HTR1D HTR1A PDPK1 HTR1B CREB1 GNAO1 MAPKAPK3 MAPKAPK2 MAP2K6 MAP2K3 PIK3CA FOS RAP1A MAPK14 MAPK1 BILE ACID SYNTHESIS AND ENTEROHEPATIC CIRCULATION %WIKIPATHWAYS_20260710%WP4389%HOMO SAPIENS Bile acid synthesis and enterohepatic circulation FGF19 FGFR4 MAPK3 FXR1 SLC10A2 ABCB11 LDLR CYP7A1 ABCG8 ABCG5 MAPK1 SCFA AND SKELETAL MUSCLE SUBSTRATE METABOLISM%WIKIPATHWAYS_20260710%WP4030%HOMO SAPIENS SCFA and skeletal muscle substrate metabolism PYY FFAR3 FFAR2 SLC2A4 GCG NR1C2 KILLER CELL IMMUNOGLOBULIN LIKE RECEPTORS AND HUMAN LEUKOCYTE ANTIGEN C PATHWAY%WIKIPATHWAYS_20260710%WP5576%HOMO SAPIENS Killer cell immunoglobulin like receptors and human leukocyte antigen C pathway GRB2 FYN TNF CSF2 PRKCA SYK HLA-C KIR2DL1 KIR2DL3 VAV1 TYROBP PRKCQ PLCG1 PTPN6 RAC1 LCP2 CD34 LAT HRAS IFNG TGF BETA RECEPTOR SIGNALING IN SKELETAL DYSPLASIAS%WIKIPATHWAYS_20260710%WP4816%HOMO SAPIENS TGF beta receptor signaling in skeletal dysplasias MAPK3 STAT3 CREBBP DKFZp781O1323 RUNX2 JUN FOS ZFYVE9 SMAD1 ADAMTSL2 JAK1 SMAD9 TGIF1 LEFTY1 IFNG FST NOG FOXH1 opn LEF1 BMP4 RUNX3 TGFBR1 TGFBR2 MAPK9 TGFBR3 ZEB2 ENG LTBP1 THBS1 WNT1 ZNF423 TNF SKIL LEFTY2 SMAD2 pp6425 EGF STAT1 SMAD4 LIF INHBA SMAD6 EP300 FKBP1A SKI BAMBI FBN1 NFKB1 ITGB6 HRAS TGFB1 CHOLESTEROL METABOLISM WITH BLOCH AND KANDUTSCH RUSSELL PATHWAYS%WIKIPATHWAYS_20260710%WP4718%HOMO SAPIENS Cholesterol metabolism with Bloch and Kandutsch Russell pathways CYP27A1 ELOVL5 ELOVL2 ABCA1 ACSL1 FACL4 ACSL3 FADS2 FADS1 MVK FASN MSMO1 HSD17B7 ACAT2 TM7SF2 EBP PMVK SC5D LBR FDFT1 MYLIP FDPS HMGCS1 GGPS1 HMGCR ELOVL4 NR1H2 ELOVL3 NR1H3 DHCR24 SREBF2 CH25H SQLE SOAT1 SOAT2 SCD MVD DHCR7 CYP46A1 ABCG1 CYP51A1 NSAIDS MECHANISM OF ACTION%WIKIPATHWAYS_20260710%WP5513%HOMO SAPIENS NSAIDs mechanism of action PTGS2 PTGS1 MOLYBDENUM COFACTOR MOCO BIOSYNTHESIS%WIKIPATHWAYS_20260710%WP4507%HOMO SAPIENS Molybdenum cofactor Moco biosynthesis MTARC2 SUOX AOX1 GPHN MOCS2 XDH MOCS1 NRP1 TRIGGERED SIGNALING IN PANCREATIC CANCER %WIKIPATHWAYS_20260710%WP5144%HOMO SAPIENS NRP1 triggered signaling in pancreatic cancer VEGFA COL1A1 COL1A2 TGFBR1 CCNE2 TGFBR2 CDK2 MAPK3 TGFBR3 SNAI1 PECAM1 SNAI2 SMAD2 EGF SMAD4 AKT3 KDR RAC1 NFKB1 NFKB2 MAP2K1 MAP2K2 EGFR NRP1 CCNE1 CDKN1B SEMA3A SRC MMP2 GSK3A RELA FLT1 CHD2 RELB CTGF PLXNA2 PLXNA1 REL PLXNA4 HGF MAPK1 MMP9 GPR143 IN MELANOCYTES AND RETINAL PIGMENT EPITHELIUM CELLS%WIKIPATHWAYS_20260710%WP4941%HOMO SAPIENS GPR143 in melanocytes and retinal pigment epithelium cells VEGFA CREB1 PMEL DKFZp686L0365 GNAS PRKCB ASIP TYRP1 TYR POMC GPR143 GNA15 PLCB3 PLCB4 ADCY9 MC1R DCT PRKACG PLCB1 PLCB2 GLUTATHIONE METABOLISM%WIKIPATHWAYS_20260710%WP100%HOMO SAPIENS Glutathione metabolism GSTM1 GSTA5 GSTT2 GPX2 GPX4 GPX3 GPX1 HEL-75 OPLAH HEL-S-64p HEL-S-26 GCLC GCLM GSTM2 FOLATE ALCOHOL AND CANCER PATHWAY HYPOTHESES%WIKIPATHWAYS_20260710%WP1589%HOMO SAPIENS Folate alcohol and cancer pathway hypotheses ADH5 MTR CREB1 CYP2E1 CBS CEBPB HEL-S-53e RENIN ANGIOTENSIN SYSTEM AND BRADYKININ PATHWAYS IN COVID 19%WIKIPATHWAYS_20260710%WP4969%HOMO SAPIENS Renin Angiotensin System and Bradykinin pathways in COVID 19 KLK1 ACE2 NR1i1 KNG1 CPN1 CYP24A1 IL1A BDKRB2 AGTR1 BDKRB1 CYP3A4 SERPING1 REN TNF AGTR2 KLKB1 PRKG1 ROCK1 ARHA IL1B NFKB1 MAPK1 GASTRIC ACID PRODUCTION%WIKIPATHWAYS_20260710%WP2596%HOMO SAPIENS Gastric acid production GAST CCK PGA3 VIP PGC PGA5 MUC6 CBLIF SCT IL4 SIGNALING%WIKIPATHWAYS_20260710%WP395%HOMO SAPIENS IL4 signaling TYK2 NFKBIA GAB2 FES MAPK3 GRB2 INPP5D STAT1 RPS6KB1 EP300 BAD PIK3CD NFKB1 PIK3R1 CEBPB ATF2 STAT3 CHUK IKBKB SOS1 IL4 PIK3CA SHC1 IRS1 PIK3R2 FOS MAPK14 PTPN6 CEBPA RELA IL2RG CBL SOCS3 SOCS1 MAPK11 FLNA JAK1 JAK3 SOCS5 STAT5B MAPK1 PTPN11 MIR TARGETED GENES IN ADIPOCYTES%WIKIPATHWAYS_20260710%WP2001%HOMO SAPIENS miR targeted genes in adipocytes CAP1 ELOVL5 PHC2 TGFBR2 IGF2R TMEM43 SRSF10 PICALM SRSF9 FADS1 LPL CYP1B1 CEBPB TMED10 OXIDATIVE DAMAGE RESPONSE%WIKIPATHWAYS_20260710%WP3941%HOMO SAPIENS Oxidative damage response BCL2 MAPK10 CDKN1C C1QB TNF C1QA C1S C5AR1 C4B_2 BAG4 CASP9 C3AR1 CR2 MAP3K1 CASP3 APAF1 GADD45A CYCS BAD TNK2 TRAF1 TNFRSF1B TRAF3 NFKBIE NFKB1 C1QC CDKN1A PCNA BAK1 MAP2K4 CDKN1B TRAF2 MAPK13 TRAF6 CDC42 IMMUNE INFILTRATION IN PANCREATIC CANCER%WIKIPATHWAYS_20260710%WP5285%HOMO SAPIENS Immune infiltration in pancreatic cancer VEGFA TNF IL1B CXCL8 IL25 CXCL1 CXCL5 CCL2 IL12B LGALS9 CCL20 REG4 IL13 VEGFB VEGFC VEGFD CXCL12 IL23A IL17F IL10 IL17D IL4 IL17C CSF2 IL5 CCL28 TGFB1 IL17B IL17A IL12A IL2 IL6 IFNG CCL5 MMP9 PRIMARY FOCAL SEGMENTAL GLOMERULOSCLEROSIS FSGS %WIKIPATHWAYS_20260710%WP2572%HOMO SAPIENS Primary focal segmental glomerulosclerosis FSGS PAX2 CD2AP INF2 COL4A4 COL4A3 YWHAQ COL4A5 MYH9 IRF6 LMX1B LAMA5 FYN CD151 NCK1 LRP6 VTN LAMB2 PARVA MYO1E NPHS1 NPHS2 WT1 FAT1 AGRN LIMS1 TLR4 CDKN1A CTSL DKK1 NOTCH1 CDKN1B LRP5 ITGB3 CDKN1C ITGB4 WNT1 HEL114 PLCG1 ITGAV PCNA HEL-S-28 TLN1 TGFB1 CD80 SCARB2 SMARCAL1 PTPRO ITGB1 HEL113 MKI67 CDH2 DAG1 PLCE1 SYNPO KIRREL3 TRPC6 KIRREL2 CLDN1 CR1 MME PLAUR ACTN4 DEGRADATION PATHWAY OF SPHINGOLIPIDS INCLUDING DISEASES%WIKIPATHWAYS_20260710%WP4153%HOMO SAPIENS Degradation pathway of sphingolipids including diseases PSAP NEU1 GLA SCARB2 HEL-S-111 HEXA LIPA NEU2 NEU3 NEU4 NPC1 GM2A GLB1 NPC2 ANGIOGENESIS OVERVIEW%WIKIPATHWAYS_20260710%WP1993%HOMO SAPIENS Angiogenesis overview VEGFA GRB2 NCK1 PRKCA MTOR ATF2 NRP1 MAPK8 ROBO4 PLXND1 SHB ROBO1 GRB14 TIMP4 F2 MMP14 GRB7 MAP2K6 PLA2G1B MAP2K4 IQGAP1 PTK2B SEMA3A VHL SLIT2 MMP2 ANGPT1 BMX NOX4 FRS2 MAPK14 FGFR1 MAPK11 MAP3K7 PTPN11 KDR PLCG1 RAC1 BAD PIK3CD APC MAP2K1 PDPK1 SOS1 RAF1 CRK SHC1 SRC PXN DAG1 WAS PAK1 MMP9 CDC42 MAPK1 MEVALONATE PATHWAY%WIKIPATHWAYS_20260710%WP3963%HOMO SAPIENS Mevalonate pathway MVD FDPS HMGCS1 HMGCR MVK ACAT2 PMVK KALLMANN SYNDROME%WIKIPATHWAYS_20260710%WP5074%HOMO SAPIENS Kallmann syndrome MAP2K2 OTX2 NEUROG1 PLXND1 GRB2 PIK3CA FRS2 FGFR1 MYRF LHB SEMA3E OLIG2 ASCL1 SOX10 FGF8 TMEM98 ANOS1 PROK2 PTPN11 MAPK1 GNRH1 8Q11 23 RB1CC1 COPY NUMBER VARIATION%WIKIPATHWAYS_20260710%WP5412%HOMO SAPIENS 8q11 23 RB1CC1 copy number variation RB1CC1 GABARAPL2 GABARAPL1 WDR45B GABARAP ATG16L1 MAP3K5 ULK1 TNF PTK2B TRAF2 ATG101 RB1 BONE MORPHOGENIC PROTEIN SIGNALING AND REGULATION%WIKIPATHWAYS_20260710%WP1425%HOMO SAPIENS Bone morphogenic protein signaling and regulation SMAD4 SMAD6 BMP2 SMURF1 TOB2 BMPR2 TOB1 RUNX2 SMAD1 BMPR1A NOG HOMOLOGOUS RECOMBINATION%WIKIPATHWAYS_20260710%WP186%HOMO SAPIENS Homologous recombination RPA1 MRE11A ATM NBN BRCA2 RAD54B RAD52 POLD3 POLD4 RAD50 RAD51 POLD2 UNFOLDED PROTEIN RESPONSE%WIKIPATHWAYS_20260710%WP4925%HOMO SAPIENS Unfolded protein response BCL2 MBTPS2 BCL2L11 PMAIP1 ATF4 BBC3 PPP1R15A MBTPS1 XBP1 IL1B RTCB TNFRSF10B EIF2S1 HEL-S-89n ERN1 DDIT3 NFE2L2 CASP2 TXNIP UREA CYCLE AND ASSOCIATED PATHWAYS%WIKIPATHWAYS_20260710%WP4595%HOMO SAPIENS Urea cycle and associated pathways FH ARG1 NOS2 HEL-S-281 NAGS ASS1 SLC25A15 GLUD1 GOT2 SLC25A12 HEL-S-32 SLC25A13 GPT OTC GLS2 ASL MDH2 PDGFR BETA PATHWAY%WIKIPATHWAYS_20260710%WP3972%HOMO SAPIENS PDGFR beta pathway MAPK8 EIF2AK2 GRB2 MAPK3 PRKCB SOS1 RAF1 PIK3CA MAP2K4 PRKCA JUN SHC1 STAT1 MAP3K1 FOS PLCG1 JAK1 HRAS PIK3R1 STAT5B MAP2K1 STAT3 NEUROINFLAMMATION%WIKIPATHWAYS_20260710%WP4919%HOMO SAPIENS Neuroinflammation NFKBIA NOS2 MAPK8 CHUK ASCC1 JUN MTOR COX2 FOS COX1 MAPK14 RELA TLR4 CAFFEINE IN MYOCYTES%WIKIPATHWAYS_20260710%WP5603%HOMO SAPIENS Caffeine in myocytes MYH6 MYH7 PS1TP5BP1 HEL-S-273 RYR1 RYR2 RYR3 ACTG2 MYH13 TNNI1 TNNI2 TNNI3 HEL-S-108 TPM3 MYL11 TNNC1 TPM1 TNNC2 ACTA2 MYH1 ACTA1 MYH2 MYL6 MYL1 TNNT1 MYL2 MYL3 ACTG1 TNNT3 MYH8 MYH4 NETWORK MAP OF SARS COV 2 SIGNALING%WIKIPATHWAYS_20260710%WP5115%HOMO SAPIENS Network map of SARS CoV 2 signaling PS1TP5BP1 FYN CD14 ACE2 CTSL GABARAPL2 APOA2 EIF4A2 IFITM3 IFITM1 HEL117 IFIT1 TBK1 GTSE1 VPS36 VPS18 IL1R2 WDR74 IFI27 DDIT4 CD226 CFB CFH CASP9 CFI CASP8 CFP CASP3 IL8RB TRPM2 LARP1 APOM RRAS APOH APOD VPS16 EGR1 HLA-DRB5 NFATC3 HEL103 PRG3 HEL-S-78p CDC2 DKFZp781O1323 BST2 MOV10 TF INTS4 HRG HLA-DRB1 IL22 CTSZ SERPINA10 SRP54 HBB CD3G HBD CD3E C8A IFIH1 MMP25 C1QBP SDF2 CCR6 CCR5 TOMM70 PARP2 SMAD1 HEL-S-72p IL18 GP1BA IL16 CCL11 HMFT1766 IFI6 CXCR1 OS9 APOL1 CCL15 IL33 CCL22 CCL21 IFNB1 MIB1 ITCH IGLL1 SAA1 SAA2 COQ8B CCL27 PF4 CCL26 SRP19 STEAP3 NRF HEL-S-130P HEL-S-81p HP AHR CXCL13 FGF2 IL-21 CXCL16 IL18RAP DEPTOR PMPCB CLCC1 TLE3 VPS33A GTF2F2 PIAS1 CD8B CD8A ADAM9 CARD11 RTN4 UGCGL2 CCNB2 TPO CCNB1 IRAK1 PITRM1 G3BP2 NLRP3 NPTX1 MDN1 FAM83A NEK9 CD163 GGH SELP MAVS TP53I3 IL7 ALB IL9 MYD88 RIGI LGALS3BP CXCL6 CXCL9 CXCL3 CXCL2 TRO CASP5 MLST8 LBP PTGS2 FGA ZAP70 IRF3 OAS2 LCK AKT1S1 BIRC5 TRIM59 IRF9 CRP ITIH4 ITIH3 CCL8 CCL4 CCL3 CCL1 EIF4E NTRK1 ATE1 RRM2 MX1 CD2 VPS41 APOC1 TBKBP1 ATP13A3 FAM98A PRKCQ PTPN6 JAK1 TGFBR2 TNF RPTOR STAT1 RAC1 RPS6 EIF4EBP1 DKFZp762B153 ULK1 RHEB HIF1A CCL5 NLRP1 MTOR CAMK4 CEBPB MAPK8 CPN1 TNFSF10 IL1A JUNB JUN TRAF2 FOS IL6 IFNG TRAF6 C1S IL1B TRAF3 NFKB2 CXCL8 CXCL1 CXCL5 CCL2 CCL20 IL13 CXCL12 IKBKG IL10 IL4 IL5 IL17A IL12A ACTG1 AKT SIGNALING AND ARTD FAMILY MEMBERS%WIKIPATHWAYS_20260710%WP5531%HOMO SAPIENS AKT signaling and ARTD family members PIK3R4 PIK3R5 FOXO1 MLST8 RPTOR TSC2 MTOR GSK3B AKT3 PIK3CD PIK3R3 TSC1 PIK3R1 SIRT1 ATM PHLPP1 MAPKAP1 STK11 RICTOR PARP3 IKBKG PIK3CA PIK3C2G PIK3R2 PIK3C2B PARP2 TESSADORI BICKNELL VAN HAAFTEN SYNDROME 3 OVERVIEW PATHWAY%WIKIPATHWAYS_20260710%WP5575%HOMO SAPIENS Tessadori Bicknell van Haaften syndrome 3 overview pathway TBP H4C9 MED23 TAF13 TAF8 MED27 SEROTONIN TRANSPORTER ACTIVITY%WIKIPATHWAYS_20260710%WP1455%HOMO SAPIENS Serotonin transporter activity TPH2 TGFB1I1 ITGB3 IL1B STX1A MAOA IL1R1 AMPK REGULATION OF MAMMARY MILK PROTEIN SYNTHESIS%WIKIPATHWAYS_20260710%WP5492%HOMO SAPIENS AMPK regulation of mammary milk protein synthesis EIF4A2 PRKAB2 PRKAB1 MLST8 CSN3 CSN2 TSC2 EEF2 MTOR RPTOR EEF2K CSN1S1 RPS6KB1 EIF4G1 PRKAA1 PRKAA2 PRKAG1 EIF4E PRKAG2 PRKAG3 ASPIRIN PREVENTION OF CANCER METASTASIS%WIKIPATHWAYS_20260710%WP5518%HOMO SAPIENS Aspirin prevention of cancer metastasis GNA13 TBXA2R ARHA ARHGEF1 PTGS1 RETT SYNDROME%WIKIPATHWAYS_20260710%WP4312%HOMO SAPIENS Rett syndrome RHOBTB2 CECR2 TBL1X HIVEP2 SCN1A SRRM3 GABBR2 MEF2C EIF2B2 CDKL5 KCNJ10 ACTL6B GABRA3 SMARCA1 SMARCA4 NCOR2 XAB2 NCOR1 TBL1XR1 SCN8A IMPDH2 HAP1 HDAC1 SCN2A TCF4 TAF1B SMC1A SYNGAP1 GNAO1 GRIN2B CRK SHANK3 CHD4 HDAC5 KDM5B TRRAP STXBP1 FOXG1 HTT GPS2 HDAC8 SYNE2 GLYCINE METABOLISM%WIKIPATHWAYS_20260710%WP1495%HOMO SAPIENS Glycine metabolism SHMT1 HEL-S-51e TARGET OF RAPAMYCIN SIGNALING%WIKIPATHWAYS_20260710%WP1471%HOMO SAPIENS Target of rapamycin signaling MLST8 PRKCA DDIT4 AKT1S1 RPTOR TSC2 MTOR RPS6KB1 PRKAA1 FKBP1A PRKAA2 RAC1 PRR5 PRKAG1 DDIT4L RRAGA PRKAG2 TSC1 RRAGB RRAGD ULK2 PRKAG3 EIF4EBP1 PRKAB2 MAPKAP1 HMGCR RICTOR PRKAB1 ULK1 RHEB CDC42 COVID 19 STRUCTURAL COVERAGE MAP%WIKIPATHWAYS_20260710%WP5145%HOMO SAPIENS COVID 19 structural coverage map ISG15 MACROH2A2 ACE2 NRP1 PARP14 SLC6A19 GDAP2 MAP3K7IP1 NLRP12 UBB UBC MACROD1 HEL97 MACROD2 CMTR1 PAIP1 PALS1 TOMM70 UPF2 AQR IGHMBP2 ARRHYTHMOGENIC RIGHT VENTRICULAR CARDIOMYOPATHY%WIKIPATHWAYS_20260710%WP2118%HOMO SAPIENS Arrhythmogenic right ventricular cardiomyopathy DSG2 DSC2 CACNA1F CACNG6 CACNG7 CACNG8 PS1TP5BP1 LMNA CTNNA1 CTNNA3 DMD CTNNA2 CACNG1 CACNA1S CACNG2 CACNG3 CACNG4 CACNG5 JUP DES LEF1 ITGB3 ITGB4 ITGA2B TCF7L2 TCF7L1 ITGB8 ITGAV ITGB7 ITGB6 CACNA1C ITGA4 ITGA2 ITGA1 RYR2 ITGA7 ITGA6 ATP2A2 SLC8A1 GJA1 SGCD SGCA ITGB1 SGCB EMD CDH2 SGCG DAG1 ACTN2 ACTN1 CACNA2D1 CACNA2D3 CACNA2D2 CACNA2D4 CACNB1 ACTG1 CACNB3 CACNB4 ACTN4 PKP2 INTERFERON MEDIATED SIGNALING%WIKIPATHWAYS_20260710%WP4558%HOMO SAPIENS Interferon mediated signaling TYK2 IFNB1 PRKCA STAT1 IRF9 IFNA5 IFNA4 IFNA7 IFNA6 IFNA1 IFNA2 IFNA8 IFNL2 IFNL1 IFNL4 PIK3R1 IFNL3 IFNA21 IFNAR2 IFNA13 IFNA14 IL10RB IFNA16 IFNGR1 STAT2 IFNA17 IFNGR2 IFNLR1 IFNW1 IFNE IFNK PIK3CA IFNA10 IFNAR1 JAK1 IFNG NUCLEOTIDE EXCISION REPAIR%WIKIPATHWAYS_20260710%WP4753%HOMO SAPIENS Nucleotide excision repair DDB1 POLE4 CDK7 POLE2 RPA3 ERCC1 POLE3 ERCC2 ERCC5 MNAT1 CUL4B POLD3 POLD4 POLD2 RPA1 PCNA CCNH CETN2 XPA XPC POLE GTF2H2C_2 RFC3 RFC4 LIG1 RFC1 RFC2 GTF2H2 GTF2H3 GTF2H4 GTF2H5 DDB2 RBX1 CUL4A 16P12 2 COPY NUMBER VARIATION SYNDROME 520KB %WIKIPATHWAYS_20260710%WP5510%HOMO SAPIENS 16p12 2 copy number variation syndrome 520kb CDK2 MAPK3 MLST8 MTOR RPS6KB1 CALM1 CDC2 COX7C EEF2 EEF2K MAPK14 MAPK12 MAPK13 MAPK11 CYB COX5A RPS6KA1 UQCRFS1 RAB5IF MOSMO RPTOR NDUFS8 UQCRC1 NDUFS3 COXFA4 UQCRC2 PRKAA1 CDH18 PRKAA2 UQCRB PRKAG1 UQCR11 UQCR10 UQCRH PRKAG2 TRPM7 CYC1 PDZD9 CDR2 PRKAG3 NDUFA9 MAP2K1 SDR42E2 MAP2K2 VWA3A UQCRQ POLR3E PRKAB2 PRKAB1 MAPK1 MITOPHAGY%WIKIPATHWAYS_20260710%WP5636%HOMO SAPIENS Mitophagy SAMM50 MFN1 MAPK10 MFN2 TBC1D17 TBC1D15 MARCHF5 PHB2 MTX1 TBK1 FIS1 BNIP3 AMFR HUWE1 CCZ1 PINK1 NBR1 TOMM7 RAB5A ATF4 MAPK8 VCP JUN TRAF2 AMBRA1 TOMM70 FOXO3A BCL2L1 MAPK9 SMURF1 MAP1LC3A EIF2S1 CALCOCO2 CITED2 TOMM20 PARK2 SP1 OPA1 FUNDC1 ARIH1 USP30 ULK1 BNIP3L CSNK2A1 ATG9B CSNK2A3 SQSTM1 CSNK2A2 ATG9A TFEB SRC MUL1 PGAM5 RAB7B OPTN HIF1A RAB7A SIAH1 USP15 RAB5B NLRX1 RAB5C TOMM40 BECN2 BCL2L13 RHOT2 RHOT1 COPPER METABOLISM%WIKIPATHWAYS_20260710%WP5189%HOMO SAPIENS Copper metabolism SLC31A1 SLC11A2 ATP7A ATP7B AMINO ACID CONJUGATION OF BENZOIC ACID%WIKIPATHWAYS_20260710%WP521%HOMO SAPIENS Amino acid conjugation of benzoic acid GLYATL2 ACSS2 GATF-C N GLYCAN BIOSYNTHESIS%WIKIPATHWAYS_20260710%WP5153%HOMO SAPIENS N glycan biosynthesis DPAGT1 B4GALT2 B4GALT1 TUSC3 GMPPB MAN1A2 MAN1A1 ALG8 ST6GAL1 ALG9 ST6GAL2 ALG6 ALG5 ALG2 ALG14 ALG13 ALG3 ALG12 ALG1 ALG11 ALG10 DDOST DPM1 DPM2 DPM3 RFT1 GCS1 MAN1B1 ALG10B RPN2 RPN1 FUT8 GANAB MAN2A2 MAN2A1 MGAT5 MGAT5B MGAT3 MGAT1 MGAT2 MPDU1 SRD5A3 DOLK MGAT4C MGAT4D MGAT4A DOLPP1 MGAT4B STT3A STT3B APOPTOSIS REGULATION BY PARATHYROID HORMONE RELATED PROTEIN%WIKIPATHWAYS_20260710%WP3872%HOMO SAPIENS Apoptosis regulation by parathyroid hormone related protein BCL2 BAX BCL2L1 BCL2A1 PTHLH BAK1 BCL2L12 BCL2L10 ITGB4 ITGA6 BCL2L2 MCL1 BCL2L14 BOK GSK3B AKT3 GSK3A MYC BCL2L13 BIOTIN METABOLISM INCLUDING IMDS%WIKIPATHWAYS_20260710%WP5031%HOMO SAPIENS Biotin metabolism including IMDs PCCB ACACB ACACA BTD HLCS PC MCCC2 PCCA MCCC1 STEROL REGULATORY ELEMENT BINDING PROTEINS SREBP SIGNALING%WIKIPATHWAYS_20260710%WP1982%HOMO SAPIENS Sterol regulatory element binding proteins SREBP signaling AMFR HEL-S-32 MTOR FASN CYP51A1 DBI MED15 YY1 PRKAA1 CAMP PRKAA2 ACLY MBTPS1 PRKAG1 RBP4 SEC23A SAR1A PRKAG2 INSIG1 INS SCARB1 DKFZp434B2017 RNF139 PRKAG3 SIRT1 SEC23B PPARG SEC31B PPARGC1B MBTPS2 FDFT1 FGF21 CREB1 SEC31A PRKAB2 FDPS NFYA HMGCS1 CDK8 GPAM HMGCR SP1 LPIN1 PRKAB1 NR1H2 SEC24C LDLR SREBF2 PIK3CA SQLE SCD MVD GSK3A ACACA LPL ACSS1 HEMATOPOIETIC STEM CELL GENE REGULATION BY GABP ALPHA BETA COMPLEX%WIKIPATHWAYS_20260710%WP3657%HOMO SAPIENS Hematopoietic stem cell gene regulation by GABP alpha beta complex BCL2 CREBBP ATM BCL2L1 FLT3 GABPB1 TERF2 MCL1 ZFX ETV6 GABPA SMARCA4 SMAD4 EP300 PTEN FOXO3A DNMT3B GABA AND GLUTAMATE SIGNALLING IN EPILEPTOGENESIS%WIKIPATHWAYS_20260710%WP5600%HOMO SAPIENS GABA and glutamate signalling in epileptogenesis PRKCA HEL-S-162eP STAT3 GLS2 GABRA3 STAT1 STIM1 HOMER1 GRIN2B DKFZp762B153 GRIN1 ARC GRIN3B GRIN3A HDAC10 DLG4 FRMPD3 CRTC1 ABAT ADARB1 GRIP1 PDIA2 PIG59 SH3GL2 SLC6A13 SLC6A12 SLC6A11 GABRG3 GABRG1 ORAI1 GRIA2 SLC1A1 SLC1A2 SLC1A3 MAPK1 SDCBP GRIA3 GRIA4 NETO2 SLC6A8 CPEB3 CACNG8 MAPK3 GABRB3 GABRB2 GABRB1 GRIK5 GRIK3 GRIK1 AP2A1 GRIK2 CACNG2 AP2A2 CABIN1 GABRR3 GRM3 GRM2 GABRR1 SUMO1 GRM6 GRM8 HDAC1 NPTN PLCB1 FFAR1 DLGAP3 SLC32A1 NRG1 C1QL3 C1QL2 PICK1 CAMK2A NRXN3 CREBBP NWD1 SNX27 ERBB4 GNA11 GABRE ATAD1 GABRQ GABRA2 GABRP MBD5 SLC12A5 GABRA6 GABRA5 GAD1 GABRA4 SYVN1 LHFPL4 SNX14 EFNB2 MAP2K1 PPP2CA SRC CDH2 SLC7A11 INTERACTIONS OF NATURAL KILLER CELLS IN PANCREATIC CANCER%WIKIPATHWAYS_20260710%WP5092%HOMO SAPIENS Interactions of natural killer cells in pancreatic cancer FOXO1 TNF CD226 CCL4 CCL3 CCL1 CCL2 CSF2 PRF1 ADAM10 BMI1 GATA2 FCGR3A KLRK1 NCR3LG1 MYC TIGIT MICA MICB CD96 NCR1 IFNG CCL5 ADAM17 NCR3 IL6 SIGNALING%WIKIPATHWAYS_20260710%WP364%HOMO SAPIENS IL6 signaling IRF-1 TYK2 NLK TIMP1 BCL2L1 IL6R NCOA1 MAPK3 NR2F6 GRB2 IL6ST STAT1 CRP GSK3B RPS6KB1 RAC1 BAD HDAC1 PIK3R1 MAP2K1 STAT3 MAP2K2 CREBBP JUNB SOS1 MAP2K4 SHC1 VAV1 VIP PIK3R2 SOCS3 MAP3K7 JAK1 IL6 MAPK1 PTPN11 PREGNANE X RECEPTOR PATHWAY%WIKIPATHWAYS_20260710%WP2876%HOMO SAPIENS Pregnane X receptor pathway NCOA1 ABCB1 FOXO1 NR1i2 CYP4F12 RXRA CYP3A4 SLCO1B1 SRPX2 CYP2C19 CYP2C9 DNAJC7 CYP3A7 PPARGC1A UGT1A1 CYP2B6 UGT1A4 SRC UGT1A3 UGT1A9 SULT2A1 ABCC3 CYP2A6 ABCC2 SELECTIVE EXPRESSION OF CHEMOKINE RECEPTORS DURING T CELL POLARIZATION%WIKIPATHWAYS_20260710%WP4494%HOMO SAPIENS Selective expression of chemokine receptors during T cell polarization IL12B IFNGR1 IFNGR2 CXCR4 IL4 CCR1 CSF2 IL5 TGFB1 CD40LG CXCR3 CCR7 IL12A IL12RB1 CCR4 IL18R1 CCR3 CCR2 IL2 CCL4 CCL3 CCR5 IFNG LAC PHE PATHWAY%WIKIPATHWAYS_20260710%WP5239%HOMO SAPIENS Lac Phe pathway ABCC5 CNDP2 GLIOBLASTOMA SIGNALING%WIKIPATHWAYS_20260710%WP2261%HOMO SAPIENS Glioblastoma signaling CDK2 MAPK3 GRB2 FOXO1 PRKCB PRKCA RB1 CDKN1A BRCA1 EGFR IGF1R MAP2K6 MAP2K3 MAP2K4 PDGFRA CDKN1B IRS1 CDKN2A PIK3C2G PIK3C2B PRKCQ FGFR1 CCND2 CBL FOXO3A ERBB2 ARAF TSC2 CCND1 BRCA2 AKT3 EP300 PLCG1 PTEN PIK3CD DKFZp781B1423 PRKCI PRKCH TSC1 MSH6 HRAS FOXO4 PIK3R1 PRKCZ ERBB3 MAP2K1 NRAS PLCG2 MAP2K2 CDKN2B MDM2 CDKN2C ATM PDPK1 CDK6 CDK4 SPRY2 CCNE1 FGFR2 RAF1 PIK3CA NF1 SRC PIK3R2 MAP2K5 MAPK1 IL10 ANTI INFLAMMATORY SIGNALING%WIKIPATHWAYS_20260710%WP4495%HOMO SAPIENS IL10 anti inflammatory signaling STAT1 HMOX1 IL10RB IL1A STAT2 HEL-S-10 IL10RA IL10 IL6 JAK1 STAT3 WNT SIGNALING NETPATH%WIKIPATHWAYS_20260710%WP363%HOMO SAPIENS Wnt signaling NetPath LEF1 NLK MAPK9 DVL1 DVL2 DVL3 DKFZp686L0365 PRKCB LRP6 NFATC2 PRKCA TCF7L2 TSC2 MTOR CSNK1A1 CCND1 GSK3B RAC1 ARHA TCF4 TSC1 APC PPARG MAPK8 CDK6 CTBP1 STM7 hCG_2014051 SOX1 RYK CSNK1D BCL9 ROR1 LRP5 ROR2 TCF3 PI4K2A CSNK1G1 GCKR FRAT1 GSK3A MAP3K7 AXIN1 MAPK1 CYTOKINE CYTOKINE RECEPTOR INTERACTION%WIKIPATHWAYS_20260710%WP5473%HOMO SAPIENS Cytokine cytokine receptor interaction GDF15 CXCR4 BMPR1A TNFRSF10B IL1R2 IL8RB BMPR2 CSF1 TNFSF11 IL22 TNFRSF11A CCR6 CCR5 IL18 CCL11 BMP6 BMP5 CXCR1 BMP4 IL6R BMP3 CCL15 IL3 IL33 CCL22 IL6ST CCL21 LEP IFNB1 CCR1 CD40LG CCL27 CCR7 PF4 IL12RB1 CCL26 CCR4 IL18R1 CCR3 CCR2 CXCL13 IL-21 CXCL16 IL18RAP IL10RA TPO CNTFR CNTF IL1RN IL23R IL27RA IL36A IL36B gdf7 IL7 ACVR1 IL15RA IL9 IL20RA IL20RB CCR10 NGFR CXCL6 XCR1 CXCL9 TNFSF14 CXCL3 TSLP CXCL2 TNFSF12 IL36G GDF1 GDF3 PPBP GDF6 GDF5 IL1F10 IL22RA1 CD27 ANP32B NODAL ACVRL1 CD40 IL20 MSTN TNFRSF13B CCL8 IL26 CCL4 IL24 CCL3 IL27 CCL1 PRL TNFRSF13C CX3CL1 CCR8 PF4V1 IL11 TNFRSF12A IL19 IL17RC IL17RB IL17RA CCL14 CCL13 CXCR5 CXCR6 TNLG7A CCL19 CCL18 RELT GDF10 CCL25 CSF2 GDF11 CCL24 CCL23 IL31 TNLG7C IL37 IL34 BMP8B GHB2 CLCF1 TNLG8A INHA CSF3 CSF3R AMHR2 EPO CCL4L2 MPL CXCL17 IL5RA CXCL14 LEPR TGFBR1 TNFRSF8 TGFBR2 IL13RA2 TNFRSF4 IL13RA1 TNLG5A IL11RA PRLR TNF EDAR TNLG2B CSF1R CSF2RB CSF2RA TNFRSF17 LIF IL36RN TNFRSF14 INHBA TNFRSF9 TNFRSF10C INHBB TNFRSF10A BMP7 INHBC INHBE GH1 IL7R BMP10 BMP15 GHR AMH TNLG1B TNFRSF18 TNFRSF19 NGF IL3RA LTA XCL2 XCL1 TNFRSF25 LTB TNFRSF21 IL9R CX3CR1 ACVR1B IL1RL1 IL1RL2 ACVR1C CCL7 IL21R ACVR2B ACVR2A IL2RA IL2RB ACKR4 ACKR3 LTBR CCL5 EPOR CXCL11 IFNA2 IFNL2 IFNL1 IFNL3 IFNAR2 IL10RB IFNGR1 TNFSF10 IL1A IFNGR2 IFNLR1 IFNW1 IFNK IFNAR1 IL2 TNFRSF1A IL2RG IL6 TNFSF6 IFNG TNFRSF11B IL1R1 TNFRSF1B CXCL8 IL25 CXCL1 CXCL5 CCL2 CCL20 IL13 CXCL12 IL23A IL17F IL10 IL17D IL17C IL4 CCL28 IL5 IL17B TGFB1 IL17A TARGETED AGENTS IN TRIPLE NEGATIVE BREAST CANCER%WIKIPATHWAYS_20260710%WP5215%HOMO SAPIENS Targeted agents in triple negative breast cancer SOS2 MAPK3 GRB2 MLST8 ARAF AKT1S1 RPTOR TSC2 MTOR AKT3 RPS6KB1 PTEN TSC1 HRAS PIK3R1 DEPTOR NRAS MAP2K1 MAP2K2 EIF4EBP1 MAPKAP1 RICTOR SOS1 RAF1 PIK3CA IRS1 PARP2 INPP4B MAPK1 REGULATORY CIRCUITS OF STAT3 SIGNALING%WIKIPATHWAYS_20260710%WP4538%HOMO SAPIENS Regulatory circuits of STAT3 signaling OSMR MAPK15 MAPK10 PTPRC F2RL2 F2RL3 MAPK3 MLST8 PRKCB IL22RA1 AKT1S1 MTOR IFNAR2 STAT3 EGFR CREBBP MAPK8 IL10RB IFNGR1 MAPKAP1 IFNGR2 AGTR1 RICTOR IFNLR1 AGTR2 IFNAR1 PDGFRA CTF1 MAPK14 MAPK12 IL2RG MAPK13 SOCS3 MAPK11 CSF3R JAK1 JAK3 MPL TYK2 IL5RA IL6R MAPK9 IL6ST IL11RA CSF2RB CSF2RA RPTOR IL7R GHR DEPTOR IL3RA IL10RA IL9R SRC IL21R CNTFR MAPK7 IL2RA IL2RB IL27RA MAPK6 MAPK4 PTPRT SETD7 TRIM28 IL15RA DUSP2 IL20RA F2R IL20RB MAPK1 CELL CYCLE%WIKIPATHWAYS_20260710%WP179%HOMO SAPIENS Cell cycle YWHAQ SMAD2 CCND1 GSK3B EP300 SMC1A CCNE1 CCNE2 CDK2 HEL2 SMC3 CDC14B CDC20 CDC23 PTTG1 PTTG2 CHEK2 CDC27 CHEK1 SKP2 SKP1 ANAPC7 CDC25B ANAPC5 HDAC2 MAD1L1 ANAPC1 ANAPC2 HDAC1 ANAPC13 PRKDC PKMYT1 ANAPC10 ANAPC11 CCNB3 ORC6 RB1 ORC3 RAD21 ORC2 CDKN1A SFN GADD45B CDC2 PLK1 CDC6 GADD45G STAG1 STAG2 ATR MCM7 ORC1L HEL-S-1 YWHAG SMC1B CCNH RBL1 CDKN1B DBF4 TFDP1 CDKN2A ESPL1 TFDP2 MCM3 MCM5 MCM6 CCND3 MCM2 CCND2 TTK FZR1 MYC CCNA2 CDC45 E2F2 E2F3 E2F4 E2F5 RBX1 CDKN2D MAD2L2 WEE1 WEE2 CDK7 CDKN1C SMAD4 RBL2 GADD45A MDM2 CDKN2B ATM CDKN2C CDK6 PCNA CDK4 CCNB2 CCNB1 TGFB1 HEL-S-93 GASTRIC CANCER NETWORK 1%WIKIPATHWAYS_20260710%WP2361%HOMO SAPIENS Gastric cancer network 1 TOP2A H4C9 INO80D NUP107 H3F3B UBE2C ACTL6A HCTP4 LIN9 GATD3 AURKA KIF15 SMOC2 NOTCH1 CENPF ESM1 RUVBL1 S100P CEP192 MYBL2 ECT2 KIF20B E2F7 APC PRADER WILLI AND ANGELMAN SYNDROME%WIKIPATHWAYS_20260710%WP3998%HOMO SAPIENS Prader Willi and Angelman syndrome NUP42 NUP85 TPR NDN NUP88 MSX1 GABRB3 CGA RAE1 RANBP2 NUP155 NUP153 KISS1 GHRH TYR TUBGCP5 POMC TUBGCP6 NUP35 GABRR3 MKRN3 GHRL TUBGCP4 GABRR1 EIF4E RB1 CDC6 GABRA5 CDKN2A LHB CCND2 GNRH1 NUP107 CCND1 HEL-S-71 PCSK1 CYFIP1 DKFZp781B1423 AHCTF1 NUP188 FMR1 UBE3A INS OXT NPAP1 PRKCZ PCM1 HERC2 NUP62 CDKN2B MDM2 BBS4 CDKN2C NUP214 CDK6 NDC1 NGF CDK4 GOLGA8S SNRPN BDNF NUP210 NUP133 FSHB GOLGA6L2 NIPA1 TACR3 NIPA2 NUP93 FEZ1 FEZ2 SNURF NUP54 NUP98 NUP58 OCA2 POM121 NUP205 SLC45A2 MAGEL2 GABRG3 SEH1L GABRG1 DLX5 RNF8 ATP10A AAAS NUP160 NHLH2 MICRORNAS IN CARDIOMYOCYTE HYPERTROPHY%WIKIPATHWAYS_20260710%WP1544%HOMO SAPIENS MicroRNAs in cardiomyocyte hypertrophy MAPK3 PRKCB LRP6 FZD1 MTOR MYLK3 MYLK NPPB PPP3CA ARHA NPPA IKBKE PLCB2 EDN1 CISH NRG1 CAMK2D GATA4 CALM1 HDAC7 EIF2B5 FZD2 STAT3 MYEF2 PLA2G2A MAPK8 NFATC4 CDK9 IGF1R RCAN1 MAP3K14 MAP2K6 MAP2K3 PRKG1 MAP2K4 CTF1 LRP5 MAPK14 HDAC5 IGF1 CDK7 IL6ST DVL1 TNF EGF LIF GSK3B RAC1 WNT3A PIK3CD PIK3R3 FGF2 NFKB1 PIK3R1 MAP2K1 MAP2K2 PDPK1 CHUK MAP3K7IP1 IKBKB FGFR2 IKBKG RAF1 PIK3CA TGFB1 PIK3R2 ROCK1 MAPK7 ROCK2 MAPK4 MAP2K5 MAPK1 HIPPO SIGNALING REGULATION%WIKIPATHWAYS_20260710%WP4540%HOMO SAPIENS Hippo signaling regulation NGFR PRKCB PRKCA MTOR PLCB3 PLCB4 PRKACG ARHA PLCB1 PLCB2 NTRK1 EGFR IGF1R GNA11 FLT4 CDH9 CDH8 CDH6 CDH4 TEAD2 TEAD3 TEAD4 PDGFRA PRKCE LATS1 LATS2 PRKAR1B PRKD3 PRKAR1A CDH10 PRKCQ FGFR1 CDH11 KIT CDH12 CDH15 CDH16 CDH17 CDH19 EPHA2 YAP1 CDH24 WWTR1 GNAL LEF1 NF2 FGFR3 GNAI3 CSF1R SMAD2 TCF7L2 TCF7L1 KDR PRKAA1 RAC1 CDH18 PRKAA2 PRKAG1 INSR PRKCI PRKAG2 PRKCH PRKCZ PRKAG3 NTRK2 PRKAB2 FGFR4 FGFR2 PRKAB1 FLT3 GNAS CDH2 FLT1 CDC42 INCLUSION BODY MYOSITIS%WIKIPATHWAYS_20260710%WP5120%HOMO SAPIENS Inclusion body myositis PSENEN BACE1 MSTN APP PSEN2 PSEN1 NFKB1 NFKB2 SIRT1 HEREDITARY LEIOMYOMATOSIS AND RENAL CELL CARCINOMA PATHWAY%WIKIPATHWAYS_20260710%WP4206%HOMO SAPIENS Hereditary leiomyomatosis and renal cell carcinoma pathway VEGFA HEL-S-133P PRKAB1 EGLN1 KEAP1 PDHA2 SLC11A2 ACACB PRKAA1 HIF1A PRKAG1 ACACA RPS6 PDHA1 NFE2L2 NICOTINE METABOLISM IN LIVER CELLS%WIKIPATHWAYS_20260710%WP1600%HOMO SAPIENS Nicotine metabolism in liver cells CYP2B6 UGT1A4 UGT1A9 AOX1 CYP2A6 FATTY ACID TRANSPORTERS%WIKIPATHWAYS_20260710%WP5061%HOMO SAPIENS Fatty acid transporters ACSL1 FACL4 ACSL3 HEL-S-104 FABP9 ACSL6 ACSL5 FABP1 FABP2 FABP5 FABP6 DBI CD36 SLC27A4 MIRNA TARGETS IN ECM AND MEMBRANE RECEPTORS%WIKIPATHWAYS_20260710%WP2911%HOMO SAPIENS miRNA targets in ECM and membrane receptors COL1A2 ITGA1 THBS1 LAMB2 LAMA4 SDC2 XB LAMC1 THBS2 COL3A1 COL4A2 COL4A1 ITGB6 COL5A3 COL6A1 COL5A2 GLP 1 FROM INTESTINE AND PANCREAS AND ROLE IN GLUCOSE HOMEOSTASIS%WIKIPATHWAYS_20260710%WP5452%HOMO SAPIENS GLP 1 from intestine and pancreas and role in glucose homeostasis PCSK2 PCSK1 GCG INS GLP1R ANGIOPOIETIN LIKE PROTEIN 8 REGULATORY PATHWAY%WIKIPATHWAYS_20260710%WP3915%HOMO SAPIENS Angiopoietin like protein 8 regulatory pathway MAPK10 FOXO1 MLST8 EIF4E RPS6KA5 MAPKAP1 MAP3K14 RICTOR FBP1 PCK1 G6PC1 SLC2A4 CYP2B6 RPTOR GSK3B PRKAA1 PRKAA2 PRKAG1 PIK3CD PIK3R3 TSC1 PRKAG2 INS PIK3R1 PRKAG3 IRS4 EIF4EBP1 CBLC RPS6KA4 PRKAB2 RPS6KA6 SESN3 RPS6KA2 MAP3K8 PRKAB1 MAP3K6 SLC16A2 NR1H3 SHC2 RAF1 MLXIPL SREBF2 MAP3K10 PIK3CA RHEB MAP3K13 MAP3K11 MAP3K12 THRA SCD HEL-S-31 GYS1 FLOT1 FLOT2 MAP4K1 GSK3A MAP4K2 EXOC7 MINK1 LPL SLCO1C1 ANGPTL8 NR1A2 MAP4K3 MAP3K2 PTPN1 MAPK1 HEL-S-42 RPS6KB2 TRIP10 MAPK3 MTOR RPS6KB1 FASN MAPK8 MAP3K5 CYP3A4 CYP7A1 MAP2K6 MAP2K3 MAP2K4 IRS1 PIK3C2G MAPK14 MAPK12 CBL MAPK13 FOXO3A MAPK11 MAP3K7 SOS2 PIK3R4 CAP1 MAPK9 RPS6KA1 TSC2 MAP3K1 INSR HRAS ABCG8 ABCG5 MAP2K1 MAP2K2 PDPK1 RAPGEF1 RXRA SOS1 CRK SHC3 SHC1 PIK3R2 MAPK7 MAPK6 MAPK4 MAP2K5 CILIARY LANDSCAPE%WIKIPATHWAYS_20260710%WP4352%HOMO SAPIENS Ciliary landscape IFT74 EXOSC4 DNPEP PGRMC2 NUP88 RMND5A STOM SNRPB2 UQCC DYNC1H1 NDUFA5 RANBP9 LRPPRC MKLN1 TTC8 PSMC6 GID4 MFAP1 RAB14 PSMC4 VAPB XPNPEP3 GID8 RQCD1 DNCL1 YPEL5 CLUAP1 GLB1 GLA IQGAP1 ECHS1 CBS YAP1 USH1C RAC1 EXOC7 MYL6 DYNC2I2 DGKE TRAF3IP1 IFT172 UBE2D2 SMC4 DCAF7 ACSL3 PSMD7 MAEA APMAP CEP97 RAB2A IFT80 ARMC8 LZTFL1 DYNC1LI1 MSH2 IFT81 HDAC2 TIPRL ERF CD2BP2 HDAC1 ARL8B DDX5 PSMD12 CTBP2 INTU PSMD13 CALM1 HTRA2 RB1 COPS7A HEL-S-296 CAMK2A IQGAP3 CDH23 CREBBP AAR2 TFAP2A CTSA BBS2 H3F3B NEK8 TFAP2B BBS1 TFAP2C MCM7 UBE2H TFAP2D TFAP2E RHBDD2 EXOC6B CNOT10 FUZ BBIP1 LSM4 COPS4 MCM3 IFT20 MCM5 COPS6 MCM6 IFT22 MCM2 EHD3 COPS5 CNOT1 WNK1 MKS1 LCN2 RANBP10 IFT27 DYNLRB2 COPS8 WEE1 IFT25 NEF3 DOCK5 TTC26 GDI1 ZMYND19 MCM9 DVL3 MCM10 MYL6B RPGR IFT52 NEFL BBS9 CEP170 TMED1 BBS7 IFT57 DFNB31 CEP290 NINL BBS5 SNAP29 RAB8A IQCB1 EIF5B NFKB1 RBM14 NUDC CNOT6L CDR2 EXOC8 APC DYNLT1 NDUFA9 EIPR1 IFT140 BBS4 DYNLT3 RAB3IL1 ARFGAP3 DYNLL2 IFT43 RABEP2 NUP133 TBC1D4 NME8 EXOC4 EXOC3 EXOC6 EXOC5 EFHC2 IFT46 MAPRE2 EXOC2 PAFAH1B1 CCDC40 HEL113 EXOC1 IFT70B POM121 IFT70A RALB WDR26 HEL-S-91n SSNA1 ANKS3 VPS4A DYNLT2B HEL-S-47e RAB21 RMND5B LEUKOTRIENE METABOLIC PATHWAY%WIKIPATHWAYS_20260710%WP5171%HOMO SAPIENS Leukotriene metabolic pathway CYP4F3 LTC4S ABCC1 ALOX5AP DPEP2 PTGR1 DECR2 ALOX5 DECR1 FATTY ACID OMEGA OXIDATION%WIKIPATHWAYS_20260710%WP206%HOMO SAPIENS Fatty acid omega oxidation ADH1C HEL-S-117 ADH1A CYP4A11 CYP2E1 ADH7 ALDH2 HEL-S-4 CYP3A4 CYP1A2 CYP1A1 CYP2A6 HEL-S-53e PEROXIREDOXIN 2 INDUCED OVARIAN FAILURE%WIKIPATHWAYS_20260710%WP4873%HOMO SAPIENS Peroxiredoxin 2 induced ovarian failure MAPK10 BAX CASP3 CYP11A1 STAR HSD3B2 HEL-S-2a PARP2 ENVELOPE PROTEINS AND THEIR POTENTIAL ROLES IN EDMD PHYSIOPATHOLOGY%WIKIPATHWAYS_20260710%WP4535%HOMO SAPIENS Envelope proteins and their potential roles in EDMD physiopathology SOS2 MAPK3 GRB2 TMEM43 SMAD2 SMAD4 ADCY9 ARHA HRAS NRAS MAP2K1 LBR MAP2K2 ADCY3 ADCY1 SOS1 SYNE4 ADCY8 SYNE3 TGFB1 ADCY6 SYNE1 ADCY5 HEL-S-15 HEL-S-7a BANF1 EMD HEL-S-61 SUN1 LEMD3 YY1AP1 PLEC CTGF SYNE2 MAPK1 WWTR1 EICOSANOID METABOLISM VIA CYTOCHROME P450 MONOOXYGENASES PATHWAY%WIKIPATHWAYS_20260710%WP4720%HOMO SAPIENS Eicosanoid metabolism via cytochrome P450 monooxygenases pathway EPHX2 CYP4A11 CYP4F2 CYP4F12 CYP4A22 NR1C1 CYP2C18 PPARG EPAC1 AND PKA REDUCTION OF RETINAL INFLAMMATION%WIKIPATHWAYS_20260710%WP5440%HOMO SAPIENS EPAC1 and PKA reduction of retinal inflammation PRKAR1B NLRP3 PRKAR1A IL1B HYPOXIA MEDIATED EMT AND STEMNESS%WIKIPATHWAYS_20260710%WP2943%HOMO SAPIENS Hypoxia mediated EMT and stemness DICER1 ASPIRIN AND MIRNAS%WIKIPATHWAYS_20260710%WP4707%HOMO SAPIENS Aspirin and miRNAs VEGFA MVD PTGS2 WNT1 NFKB1 NR1C1 PTGS1 TYPE II INTERFERON SIGNALING%WIKIPATHWAYS_20260710%WP619%HOMO SAPIENS Type II interferon signaling IFI6 IRF-1 HLA-B CYBB CXCL9 MHC2TA PSMB9 OAS1 IRF4 IRF2 IRF8 IFNB1 STAT1 IRF9 IL1B IFNA2 ISG15 H4C9 NOS2 IFNGR1 EIF2AK2 STAT2 IFNGR2 SOCS3 SOCS1 JAK1 SPI1 IFNG IFIT2 GBP1 PTPN11 17P13 3 YWHAE COPY NUMBER VARIATION%WIKIPATHWAYS_20260710%WP5376%HOMO SAPIENS 17p13 3 YWHAE copy number variation HEL2 YWHAQ DCTN6 DYNC1H1 DCTN5 DBH PPP2CA DDC DCTN1 HEL-S-1 DCTN4 YWHAG DCTN3 HEL-S-77 CDK5 DISC1 PAFAH1B1 NDEL1 HEL-S-93 TH LDL INFLUENCE ON CD14 AND TLR4%WIKIPATHWAYS_20260710%WP5272%HOMO SAPIENS LDL influence on CD14 and TLR4 CREB1 CD14 IL10 ATF4 CREB3 CREB3L3 MAPK14 CREB3L4 MAPK12 CREB3L2 RELA CREB5 IL1B MAPK13 RELB NFKB1 MAPK11 NFKB2 IL6 REL CCL2 TLR4 EV RELEASE FROM CARDIAC CELLS AND THEIR FUNCTIONAL EFFECTS%WIKIPATHWAYS_20260710%WP3297%HOMO SAPIENS EV release from cardiac cells and their functional effects ERBB4 RGS16 CXCL12 MYB PRL KLF2 NEOVASCULARIZATION PROCESSES%WIKIPATHWAYS_20260710%WP4331%HOMO SAPIENS Neovascularization processes TGFBR1 MAPK9 MAPK3 CXCR4 SMAD2 ACVRL1 KDR NOTCH3 NFKB1 NOTCH4 NFKB2 DLL4 EPHB2 EPHB4 KITLG MAPK8 DKFZp781O1323 FLT4 CXCL12 NOTCH1 TGFB1 ANGPT1 HIF1A RELA KIT RELB SMAD1 SMAD9 REL MAPK1 MMP9 ANDROGEN RECEPTOR NETWORK IN PROSTATE CANCER%WIKIPATHWAYS_20260710%WP2263%HOMO SAPIENS Androgen receptor network in prostate cancer GRB2 STAT3 BRCA1 RICTOR HSD3B2 PTK2B EIF4E1B JAK1 ACTL6B SMAD2 RAD50 SMARCA4 RPTOR STAT1 MRE11A CCND1 PTEN TSC1 BARD1 HSD17B7 FOXA1 ATF1 EIF4EBP1 CRKL SMARCC1 SPINK1 SMARCC2 ERG FKBP5 BLM KLK3 NOXA1 RAF1 F13B ARID1A PIK3CA RHEB ETV4 ARID1B SMARCD1 SMARCD2 SMARCD3 HSD17B3 HSD17B4 HSD17B1 MAP4K1 HSD17B2 HSD3B1 SPRY1 PAK1 HGF MAPK1 CDK2 MAPK3 CHEK2 CHEK1 MTOR CASP9 CDC25B MSH2 CASP8 CASP3 PRKDC RB1 CDKN1A CDC2 MAPK8 PLK1 CPN1 ATR CYP17A1 JUN CDKN1B CDKN2A FOS MAPK14 MYC PTPN11 BCL2 BAX ACTL6A TSC2 BAD MSH6 HRAS MAP2K1 MAP2K2 MDM2 CDKN2B ATM CDK4 SPRY2 SP1 RAPGEF1 SOS1 CRK DOCK1 PXN RAP1A SARS COV 2 B 1 1 7 VARIANT ANTAGONISES INNATE IMMUNE ACTIVATION%WIKIPATHWAYS_20260710%WP5116%HOMO SAPIENS SARS CoV 2 B 1 1 7 variant antagonises innate immune activation TBK1 TOMM70 TRAF3 IFNB1 IKBKE MAVS IRF3 TRAF6 RIGI GLP 1 IN PANCREATIC ISLET CELLS%WIKIPATHWAYS_20260710%WP5447%HOMO SAPIENS GLP 1 in pancreatic islet cells SLC2A2 IL6R IL6 GCG INS GLP1R ANGIOGENESIS%WIKIPATHWAYS_20260710%WP1539%HOMO SAPIENS Angiogenesis VEGFA CREBBP FGFR2 PIK3CA PDGFRA ANGPT1 SRC KDR MAPK14 PLCG1 HIF1A FLT1 TIMP3 SMAD1 FGF2 MMP9 MAPK1 MAJOR RECEPTORS TARGETED BY EPINEPHRINE AND NOREPINEPHRINE%WIKIPATHWAYS_20260710%WP4589%HOMO SAPIENS Major receptors targeted by epinephrine and norepinephrine ADCY3 ADCY1 ADCY8 ADCY6 ADCY5 HEL-S-7a ADCY9 ADRA1D ADRB1 ADRB2 ADRA2C ADRA2B ADRA2A METABOLIC PATHWAY OF LDL HDL AND TG INCLUDING DISEASES%WIKIPATHWAYS_20260710%WP4522%HOMO SAPIENS Metabolic pathway of LDL HDL and TG including diseases PCSK9 LIPG APOE APOB ABCA1 LDLR MTTP APOA2 LPL SCARB1 LIPC APOC2 ANXA2 INHIBITION OF GNAQ REGULATED SIGNALING IN UVEAL MELANOMA%WIKIPATHWAYS_20260710%WP5490%HOMO SAPIENS Inhibition of GNAQ regulated signaling in uveal melanoma TRIO PKN3 MOB1A PKN2 PKN1 TSC2 MTOR PLCB3 PLCB4 AKT3 ARHA PLCB1 PIK3CD PLCB2 PIK3R3 TSC1 PIK3R1 TEAD2 TEAD3 PIK3CA TEAD4 LATS1 LATS2 PIK3R2 ROCK1 YAP1 MAPK1 ETHANOL EFFECTS ON HISTONE MODIFICATIONS%WIKIPATHWAYS_20260710%WP3996%HOMO SAPIENS Ethanol effects on histone modifications CYP2E1 KAT2B SLC19A1 ELP3 ALDH1A3 ALDH1A2 HAT1 HDAC2 ACSS2 HDAC1 HDAC7 ATF2 HEL-S-53e ADH1C HEL-S-117 ADH1A HDAC3 ALDH2 HDAC10 MTR MAT1A TYMS DHFR HDAC5 HDAC8 DNA REPLICATION%WIKIPATHWAYS_20260710%WP466%HOMO SAPIENS DNA replication POLE2 RPA3 CDK2 MCM10 POLD3 POLD4 PRIM2 PRIM1 GMNN POLD2 CDT1 RPA1 POLA1 POLA2 RPA4 ORC6 ORC3 ORC2 PCNA CDC6 UBC MCM7 ORC1L DBF4 POLE MCM3 RFC3 MCM5 RFC4 MCM6 MCM2 RFC1 RFC2 CDC45 FGF23 SIGNALING IN HYPOPHOSPHATEMIC RICKETS AND RELATED DISORDERS%WIKIPATHWAYS_20260710%WP4790%HOMO SAPIENS FGF23 signaling in hypophosphatemic rickets and related disorders CDKN1A opn FGFR3 PTH CYP24A1 FGFR2 FAM20C CYP27B1 CYP11B2 SLC34A1 CCND1 SLC34A3 KL GALNT3 DMP1 ALPL ENPP1 NFKB1 FGF23 NFKB2 ORAI1 ROS1 LACTO SERIES SPHINGOLIPID METABOLISM%WIKIPATHWAYS_20260710%WP5303%HOMO SAPIENS Lacto series sphingolipid metabolism B3GALT1 FUT1 hCG_1998026 B3GALT2 B3GNT5 FUT3 NCRNAS INVOLVED IN STAT3 SIGNALING IN HEPATOCELLULAR CARCINOMA%WIKIPATHWAYS_20260710%WP4337%HOMO SAPIENS ncRNAs involved in STAT3 signaling in hepatocellular carcinoma SOX4 IL6R IL6ST RELA IL11RA NFKB1 IL6 JAK1 JAK3 IL11 STAT3 SARS COV 2 INNATE IMMUNITY EVASION AND CELL SPECIFIC IMMUNE RESPONSE%WIKIPATHWAYS_20260710%WP5039%HOMO SAPIENS SARS CoV 2 innate immunity evasion and cell specific immune response CXCL6 CXCL9 CXCL3 IFITM1 CXCL2 TBK1 RAE1 PPBP IRF3 TRADD CASP8 CXCL11 HDAC2 IL8RB RIPK1 LARP1 CCL4 FADD CCL3 MX1 IFNAR2 AP1G1 ACE2 DHX58 TRIM25 TFAP2A HAVCR2 hEMMPRIN STAT2 IRF7 TANK TLR7 CD160 CSF2 IFNAR1 TRAF2 JAK1 IL6 IFIT2 TRAF6 TRAF5 CXCL17 IL6R IFNB1 TNF STAT1 PF4 EP300 TRAF3 CXCL13 NFKB1 CXCL8 CXCL1 CXCL5 CCL2 CXCL12 IL10 TGFB1 NUP98 MAVS TP53I3 CCL5 RIGI GLYCEROPHOSPHOLIPID BIOSYNTHETIC PATHWAY%WIKIPATHWAYS_20260710%WP2533%HOMO SAPIENS Glycerophospholipid biosynthetic pathway PIK3CD PLA2G2A GPAM LPIN1 MOGAT3 PGS1 HMFN0839 PTDSS1 PIK3CA GPAT4 PTPMT1 PIP5K1A CDIPT GPAT2 CEPT1 CHKB PI4K2A IPMK CRLS1 GNPAT GPD1 PEMT CHPT1 LPIN2 CDS2 PLURIPOTENT STEM CELL DIFFERENTIATION PATHWAY%WIKIPATHWAYS_20260710%WP2848%HOMO SAPIENS Pluripotent stem cell differentiation pathway SHH VEGFA CXCR1 FLT3LG BMP4 FGF10 IL6R IL3 WNT1 GDF5 CSF1R EGF NODAL INHBA WNT3A WNT7B CSF1 FGF2 INS IL11 KITLG TNFSF11 TF DKK1 TPO NOTCH1 WNT2B TGFB1 CNTF KIT ALK FGF8 IL6 PDGFA EPO FGF4 LEFTY1 NTF4 HGF FST IGF1 NT5E NOG ESTRADIOL REGULATION IN PORTO SINUSOIDAL VASCULAR DISEASE%WIKIPATHWAYS_20260710%WP5235%HOMO SAPIENS Estradiol regulation in porto sinusoidal vascular disease SP3 KCNN3 SP1 CALM1 RESOLVIN E1 AND RESOLVIN D1 SIGNALING DECREASE INFLAMMATION%WIKIPATHWAYS_20260710%WP5191%HOMO SAPIENS Resolvin E1 and resolvin D1 signaling decrease inflammation MTOR GRK1 LTB4R FPR2 CMKLR1 PIK3CD PIK3CA EPHB2 RUBINSTEIN TAYBI SYNDROME 1%WIKIPATHWAYS_20260710%WP5367%HOMO SAPIENS Rubinstein Taybi syndrome 1 CREBBP SMAD4 PCNA CREB1 NPAS2 IRF2 FOXO1 FBL MAFG HEL23 DDX21 PHOTODYNAMIC THERAPY INDUCED NF KB SURVIVAL SIGNALING%WIKIPATHWAYS_20260710%WP3617%HOMO SAPIENS Photodynamic therapy induced NF kB survival signaling VEGFA CXCL2 BCL2A1 VCAM1 PTGS2 BCL2L2 TNF EGLN2 MMP3 SELE CD40LG BIRC5 BIRC2 CCND1 IL1B BIRC3 NFKB1 CXCL8 NFKB2 CHUK IKBKB IL1A CSF2 MMP2 RELA IL2 TNFRSF1A RELB IL6 REL TRAF6 MMP9 REGULATION OF TOLL LIKE RECEPTOR SIGNALING%WIKIPATHWAYS_20260710%WP1449%HOMO SAPIENS Regulation of toll like receptor signaling NFKBIA MAPK10 CXCL9 MLST8 LBP CD14 IRF3 CD40 CCL4 CCL3 IKBKE CISH TLR5 TLR4 TLR7 SYK PTPN6 opn TNF STAT1 SMAD6 RAC1 PIK3CD PIK3R3 PIK3R1 MAP3K7IP1 MAP3K8 PIK3CA SQSTM1 RELA CCL5 MAPK1 MAPK3 TBK1 CXCL11 CASP8 IFNA5 IFNA4 RIPK1 IFNA7 FADD IFNA6 IFNA1 IFNA2 IFNA8 IFNA21 IFNAR2 IFNA13 IFNA14 MAPK8 IFNA16 PLK1 IFNA17 IRF7 MAP2K6 MAP2K3 IFNA10 MAP2K4 IFNAR1 JUN FOS MAPK14 MAPK12 MAPK13 SOCS1 MAPK11 MAP3K7 IL6 TRAF6 PIK3R5 MAPK9 IFNB1 OTUD5 TICAM2 FBXW5 AKT3 CD180 TRAFD1 TICAM1 RNF41 SIGIRR IL1B BTK TRAF3 RBCK1 IRAK2 NFKB1 NFKB2 CYLD CXCL8 TAB3 CUEDC2 TNFAIP3 MAP2K1 TREM1 IL12B MAP2K2 TMED7 MBL2 SFTPD CHUK IRAK3 IRAK4 IKBKB TIRAP TLR1 PELI1 TLR9 TLR8 IKBKG ZMYND11 TLR3 RNF31 SFTPA2 IRAK1 PELI3 CD80 TIFA SARM1 IL12A PIK3R2 LY96 MYD88 PHOTODYNAMIC THERAPY INDUCED UNFOLDED PROTEIN RESPONSE%WIKIPATHWAYS_20260710%WP3613%HOMO SAPIENS Photodynamic therapy induced unfolded protein response BCL2L11 ASNS SULT1E1 EIF2A ATF4 EDEM1 UBE2E1 HEL-S-99n BBC3 HEL-S-125m PPP1R15A DNAJC3 NARS1 XBP1 DNAJB11 DNAJB9 ERP27 TRIB3 HEL-S-89n ATF3 ERN1 DDIT3 NFE2L2 TRANSLATION INHIBITORS IN CHRONICALLY ACTIVATED PDGFRA CELLS%WIKIPATHWAYS_20260710%WP4566%HOMO SAPIENS Translation inhibitors in chronically activated PDGFRA cells RPS6KB2 MAPK10 EIF4A2 MAPK9 MAPK3 RPS6KA1 PRKCA RPTOR MTOR AKT3 RPS6KB1 RPS6 PIK3R3 EIF4E RPS6KA5 PIK3R1 MAP2K1 MAP2K2 EIF4EBP1 MAPK8 RPS6KA4 RPS6KA2 MAP2K6 MAP2K3 CSNK2A1 PIK3CA MAP2K4 PIK3R2 EIF4G1 MAPK14 MAP2K5 EIF4A1 PIM1 PIM2 MAPK1 EIF4B BIOSYNTHESIS AND REGENERATION OF TETRAHYDROBIOPTERIN AND CATABOLISM OF PHENYLALANINE%WIKIPATHWAYS_20260710%WP4156%HOMO SAPIENS Biosynthesis and regeneration of tetrahydrobiopterin and catabolism of phenylalanine PNMT AANAT SPR PAH ASMT JDP1 DHFR TH PTS DBH MAOA GENETIC CAUSES OF PORTO SINUSOIDAL VASCULAR DISEASE%WIKIPATHWAYS_20260710%WP5269%HOMO SAPIENS Genetic causes of porto sinusoidal vascular disease CYBB KCNN3 MAPK3 DOCK6 CYBC1 NCF1 NCF2 NCF4 COX4I2 CXXC5 RBPJ DGUOK CHCHD2 C4orf54 BEND6 GTF2I EFL1 RAC1 CYBA SHCBP1 ARHGAP31 IBTK BTK EIF6 NFKB1 SBDS NOTCH4 NOX3 DLL4 SP1 TLR9 TLR8 NOTCH1 CDC42 MAPK1 MIR 222 IN EXERCISE INDUCED CARDIAC GROWTH%WIKIPATHWAYS_20260710%WP3938%HOMO SAPIENS miR 222 in exercise induced cardiac growth HMBOX1 HIPK1 HIPK2 CDKN1B TRANSCRIPTION FACTOR REGULATION IN ADIPOGENESIS%WIKIPATHWAYS_20260710%WP3599%HOMO SAPIENS Transcription factor regulation in adipogenesis TWIST1 MAPK8 CREB1 PCK2 LPIN1 FOXO1 LEP RXRA SLC2A4 TNF PPARGC1A NR3C1 IRS1 CEBPA INSR IL6 CEBPB CEBPD PPARG CONVERSION OF ANGIOTENSINOGEN TO ANGIOTENSIN II %WIKIPATHWAYS_20260710%WP4818%HOMO SAPIENS Conversion of angiotensinogen to angiotensin II CMA1 CTSG HEL-S-130P REN NOTCH1 REGULATION OF ENDOTHELIAL CELL CALCIFICATION%WIKIPATHWAYS_20260710%WP3413%HOMO SAPIENS NOTCH1 regulation of endothelial cell calcification VEGFA FGFR3 JAG2 ITGA1 LPAR1 PLAT DLL3 GJA5 MGP CALU SOX6 NOTCH1 ALPL DLL4 METABOLIC REPROGRAMMING IN PANCREATIC CANCER%WIKIPATHWAYS_20260710%WP5220%HOMO SAPIENS Metabolic reprogramming in pancreatic cancer HEL-S-133P PFKL HK2 HEL-S-32 HEL-S-30 GPT ACLY FASN DLAT HMGCR LDLR GLUD1 RPE GOT2 ME1 PGM3 DLD GNPNAT1 SOAT1 SLC16A4 PDHX GFPT1 RPIA CS GLS2 SLC7A5 CARM1 BCAT2 PDHA1 DEVELOPMENT OF URETERIC DERIVED COLLECTING SYSTEM%WIKIPATHWAYS_20260710%WP5053%HOMO SAPIENS Development of ureteric derived collecting system SHH GPC3 PAX2 BMP5 EYA1 BMP4 CRIM1 DCN ETV5 NR1B3 BMP2 CTDNEP1 FRAS1 GDNF SMO BMPR1A RARA RARB FREM1 FREM2 CCND1 BMP7 BMPR2 ETV4 GDF11 TGFB1 GRIP1 RET SPRY1 SIX1 HOXD11 SMAD1 CELSR1 GLI3 HOXA11 SALL1 ANOS1 BMPER FST SIX2 EFFECT OF INTESTINAL MICROBIOME ON ANTICOAGULANT RESPONSE OF VITAMIN K ANTAGONISTS%WIKIPATHWAYS_20260710%WP5273%HOMO SAPIENS Effect of intestinal microbiome on anticoagulant response of vitamin K antagonists NR1i1 CD36 NR1i2 CYP2C9 NR1C1 SCARB1 NR1C2 NPC1L1 LNCRNA LIKE NMRK2 IN TRANSLOCATION RENAL CELL CARCINOMA%WIKIPATHWAYS_20260710%WP5519%HOMO SAPIENS LncRNA like NMRK2 in translocation renal cell carcinoma SLC19A2 FH CS MDH2 NMRK2 BURN WOUND HEALING%WIKIPATHWAYS_20260710%WP5055%HOMO SAPIENS Burn wound healing VEGFA COL1A1 COL1A2 PECAM1 SNAI2 CASP3 IL8RB IFNA2 TLR4 CD3E MMP2 HMGB1 NOX4 FGFR1 IL6 FST BCL2 BAX TIMP1 FGFR3 DCN ACHE CXCR4 IFNB1 TNF EGF FOXE1 HEXD INHBA TNC F13A1 MMP28 KRT6A KRT222 IL1B FBN1 S100A6 S100A9 PCTK1 NFKB1 CXCL8 FLG TAGLN CXCL1 CHRNA7 SCEL CCL2 BRD4 AMBP HEL-S-43 KLF4 SLURP1 FGFR4 LIN28A TPT1 FGFR2 CXCL12 ACTA1 HGF MYD88 MMP9 PI3K AKT SIGNALING%WIKIPATHWAYS_20260710%WP4172%HOMO SAPIENS PI3K Akt signaling COL4A4 COL4A3 COL4A5 LAMA5 VTN PRKCA LAMB2 ATF4 TLR4 BRCA1 LPAR1 IGF1R FLT4 ANGPT1 FGFR1 KIT EIF4E1B FGF8 EPHA2 FGFR3 TNC LAMA4 XB LAMC1 THBS2 COL4A2 COL4A1 INS COL6A1 FGF19 FGF21 FGFR4 PPP2R2A TCL1B TCL1A FLT3 PPP2R1B KPG_010 CDC37 TGFA LPAR2 LPAR3 LPAR4 GNG10 PDGFD CD19 GYS1 PDGFC IGF2 GNG12 GNG11 GNG13 COL9A1 COL9A3 COL9A2 GYS2 GNGT2 COL2A1 SGK1 SGK2 PHLPP2 RPS6KB2 RELN NTF3 OSM CSHL1 GHB3 CHRM2 CHRM1 FGF3 COMP FGF6 FGF9 IBSP TNR DDIT4 COL4A6 CSH2 EFNA5 EFNA4 CASP9 CHAD FGF20 FGF22 FGF17 EFNA1 G6PC2 EFNA3 CSF1 FGF14 EFNA2 G6PC3 GNB2 FGF18 GNB4 GNB3 GNB5 FGF13 FGF12 HSP90AB1 LAMC2 VWF PPP2R5B PPP2R5A COL6A6 COL6A5 ATF6B LAMA1 LAMA3 THBS4 THBS3 GNG3 GNG2 GNG5 GNG4 PPP2R3C GNG7 GNG8 ANGPT4 ANGPT2 LAMB3 LAMB4 PPP2R3B LAMB1 PPP2R3A PPP2R2C IGF1 PPP2R2B PPP2R2D PIK3AP1 IL6R IL3 IFNB1 ITGB4 ITGA2B AKT3 PPP2R1A ITGB8 ITGAV FGF2 ITGB7 PPP2R5D ITGB6 HRAS MAP2K1 MAP2K2 ITGA4 CDK6 PDPK1 CDK4 ITGA2 ITGA1 FGFR2 PPP2CA ITGA7 ITGA6 SOS1 PIK3R2 IL7 NGFR GRB2 MLST8 PRL EIF4E NTRK1 PHLPP1 STK11 SYK GHB2 CSF3 PCK1 JAK1 CSF3R EPO opn G6PC1 THBS1 PRLR CSF1R EGF RPTOR CCND1 CREB3 CREB3L3 KDR GSK3B CREB3L4 PRKAA1 CREB3L2 RAC1 PRKAA2 PTEN CREB5 MYB RPS6 PIK3CD PIK3R3 TSC1 GH1 IL7R PIK3R1 GHR NRAS KITLG EIF4EBP1 CREB1 NTRK2 NGF IL3RA CCNE1 BDNF RAF1 PIK3CA RHEB IL2RA RELA IL2RB FLT1 HGF F2R MAPK1 OSMR VEGFA COL1A1 COL1A2 CCNE2 PCK2 CDK2 PKN3 MAPK3 PKN2 PKN1 EPOR MTOR IFNA5 RPS6KB1 IFNA4 IFNA7 IFNA6 IFNA1 IFNA2 IFNA8 FGF23 IFNA21 ATF2 IFNAR2 CDKN1A IFNA13 EGFR IFNA14 FGF7 IFNA16 BCL2L11 IFNA17 MCL1 IFNA10 IFNAR1 PDGFRA CDKN1B IRS1 CCND3 IL2 CCND2 IL2RG PPP2R5E MYC FOXO3A IL6 PDGFA TNFSF6 JAK3 FGF4 NTF4 PPP2R5C BCL2 SOS2 FLT3LG FGF10 BCL2L1 PIK3R5 ITGB3 TSC2 RBL2 BAD INSR NFKB1 MDM2 CHUK GNGT1 IKBKB VEGFB VEGFC VEGFD GNB1 IKBKG IL4 ITGB1 HEL-S-125m EIF4B IL23 INHIBITORS IN INFLAMMATORY BOWEL DISEASE%WIKIPATHWAYS_20260710%WP5516%HOMO SAPIENS IL23 inhibitors in inflammatory bowel disease TYK2 IL12B RORC STAT4 IL22 IL23A IL17F TNF CSF2 IL17A STAT1 IL12RB1 IFNG STAT5B STAT3 TLR4 MULTIPLE SCLEROSIS MECHANISM AND THERAPIES%WIKIPATHWAYS_20260710%WP5540%HOMO SAPIENS Multiple sclerosis mechanism and therapies ITGA4 ITGB1 S1PR1 HEL-S-171mP S1PR3 S1PR5 S1PR4 BTK MS4A1 COLCHICINE METABOLIC PATHWAY%WIKIPATHWAYS_20260710%WP2536%HOMO SAPIENS Colchicine metabolic pathway CYP3A4 HOST PATHOGEN INTERACTION OF HUMAN CORONAVIRUSES AUTOPHAGY%WIKIPATHWAYS_20260710%WP4863%HOMO SAPIENS Host pathogen interaction of human coronaviruses autophagy RB1CC1 PIK3R4 ATG3 ATG10 ATG16L1 WIPI1 ATG12 ZFYVE1 ULK1 ATG16L2 MTOR MAP1LC3A ULK2 DKFZp686F0183 SEROTONIN RECEPTOR 2 AND ELK SRF GATA4 SIGNALING%WIKIPATHWAYS_20260710%WP732%HOMO SAPIENS Serotonin receptor 2 and ELK SRF GATA4 signaling MAP2K2 MAPKAPK2 MAPK3 RASGRF1 HTR2A RAF1 HTR2B GATA4 HRAS MAP2K1 NRAS MAPK1 NUCLEOTIDE METABOLISM%WIKIPATHWAYS_20260710%WP404%HOMO SAPIENS Nucleotide metabolism RRM1 ADSL NME2 OAZ1 SRM POLA1 RRM2B IMPDH1 ADSS POLG DHFR MTHFD2 RRM2 CALORIC RESTRICTION AND AGING%WIKIPATHWAYS_20260710%WP4191%HOMO SAPIENS Caloric restriction and aging MTOR PRKAB2 NAMPT PPARGC1A IGF1 SIRT1 ARIPIPRAZOLE METABOLIC PATHWAY%WIKIPATHWAYS_20260710%WP2640%HOMO SAPIENS Aripiprazole metabolic pathway CYP3A43 FTO OBESITY VARIANT MECHANISM%WIKIPATHWAYS_20260710%WP3407%HOMO SAPIENS FTO obesity variant mechanism TBX1 IRX5 IRX3 PRDM16 UCP1 ARID5B PPARGC1A T CELL ACTIVATION SARS COV 2%WIKIPATHWAYS_20260710%WP5098%HOMO SAPIENS T cell activation SARS CoV 2 NFKBIA PTPRC MAPK3 GRB2 MLST8 FYN ZAP70 LCK MTOR IFNAR2 CDKN1A RICTOR HLA-DRB1 CCL19 IFNAR1 CD3G JUN CD3E CDKN2A FOS PRKCQ LCP2 IL2 LAT FOXO3A IFNG NFATC1 TYK2 BAX STAT4 BCL2L1 IFNB1 TNF RPTOR TSC2 IL12RB1 CCND1 GSK3B IL18R1 PLCG1 PTEN PIK3CD TSC1 NFKB1 HRAS CD3D PIK3R1 IRF2BPL DEPTOR PPP3CC MAP2K1 GRAP2 IL12B MAP2K2 BCL10 PDPK1 ICOS CHUK IKBKB LTA CARD11 IL23A IKBKG SOS1 RAF1 IL4 RHEB CCL28 CD80 IL17A CTLA4 IL12A RELA IL23R MYD88 MAPK1 NEURAL CREST DIFFERENTIATION%WIKIPATHWAYS_20260710%WP2064%HOMO SAPIENS Neural crest differentiation ZIC5 PHOX2B GFAP GJB1 TLX2 MSX1 LHX1 SNAI1 ID1 PMP22 SNAI2 LHX5 RBPJ HDAC2 DCT HDAC1 TCF4 CTBP2 HDAC7 TWIST1 TFAP2A DLL3 TFAP2B CDH6 NOTCH1 FGFR1 HDAC5 OLIG2 MYC ASCL1 SMAD1 SOX10 FGF8 AXIN1 HDAC8 BMP4 NEUROG1 FGFR3 DVL1 DVL2 DVL3 WNT1 TCF7L1 GSK3B WNT3A BMP7 MYB FGF2 NOTCH3 NFKB1 NOTCH4 NFKB2 DLL4 FGF19 HDAC11 DMBX1 HDAC3 MPZ FGFR2 ZIC1 HEY2 HOXA1 SOX9 SOX5 FOXD3 MSX2 MIA HDAC10 OLIG3 PAX3 OLIG1 AXIN2 ISL1 ITGB1 RHOB PAX7 CDH2 HAND1 HOXB1 NOTCH2 COL11A2 TBX6 WNT8A DLX5 PRTG GBX2 HES1 COL2A1 MBP HES5 FZD3 EBSTEIN BARR VIRUS LMP1 SIGNALING%WIKIPATHWAYS_20260710%WP262%HOMO SAPIENS Ebstein Barr virus LMP1 signaling NFKBIA CCL20 MAPK8 CHUK IKBKB MAP3K14 IFNB1 IKBKG TNF IRAK1 TRADD TRAF1 RELA PDLIM7 NFKB1 CXCL8 NFKB2 MAP3K7 TRAF6 CCL5 MAPK1 PENTOSE PHOSPHATE METABOLISM%WIKIPATHWAYS_20260710%WP134%HOMO SAPIENS Pentose phosphate metabolism RPIA HEL107 HEL-S-304 RPE TRYPTOPHAN METABOLISM%WIKIPATHWAYS_20260710%WP465%HOMO SAPIENS Tryptophan metabolism AADAT AANAT ASMT TPH2 DDC TPH1 HAAO IL4I1 TDO2 KYNU AFMID AOC1 STAT1 KMO KYAT3 KYAT1 IDO2 ALDH8A1 IDO1 AHR INMT ALDH2 ACAT1 GOT2 MAOA DLD GCDH ECHS1 CYP1A1 AOX1 FACTORS AND PATHWAYS AFFECTING INSULIN LIKE GROWTH FACTOR IGF1 AKT SIGNALING%WIKIPATHWAYS_20260710%WP3850%HOMO SAPIENS Factors and pathways affecting insulin like growth factor IGF1 Akt signaling MLST8 EIF2B2 TNLG5A PPARGC1A SMAD2 AKT1S1 RPTOR MTOR MAP1LC3A FBXO32 GSK3B RPS6KB1 MSTN PTEN TRIM63 IGFBP5 EIF4E NFKB1 DEPTOR IGF1R MAPKAP1 HEL-S-28 RICTOR PRKAB1 IRS1 ITGB1 ACVR2B TNFRSF1A WASL IGF1 GNAQ P R183Q DRIVES CAPILLARY MALFORMATION%WIKIPATHWAYS_20260710%WP5501%HOMO SAPIENS GNAQ p R183Q drives capillary malformation RCAN1 PKN3 PKN2 PKN1 PRKCB PRKCA PRKCE PLCB3 PRKD3 PRKCQ PPP3CA ANGPT2 PRKCI PPP3R1 PRKCH PPP3R2 PRKD2 PRKD1 NFATC1 PRKCZ PPP3CC CANONICAL AND NON CANONICAL TGF B SIGNALING%WIKIPATHWAYS_20260710%WP3874%HOMO SAPIENS Canonical and non canonical TGF B signaling GREM1 BMP1 MAPK8 TGFBR1 TGFBR2 MAPK9 BMPR1A SMAD2 TGFB1 SMAD4 MAPK14 BMPR2 LOXL4 LOXL1 LOXL2 TYROSINE KINASE INHIBITORS IN GLIOBLASTOMA%WIKIPATHWAYS_20260710%WP5494%HOMO SAPIENS Tyrosine kinase inhibitors in glioblastoma TYK2 SOS2 EREG BTC GRB2 SOS1 RAF1 TGFA RHEB EGF TSC2 MTOR RPTOR AKT3 PTEN TSC1 JAK1 HRAS JAK3 STAT3 NRAS FATTY ACID BETA OXIDATION%WIKIPATHWAYS_20260710%WP143%HOMO SAPIENS Fatty acid beta oxidation ACADVL CPT1A CPT2 ACSL1 FACL4 HEL-S-49 ACSL3 SLC25A20 HADHB ACADL ACSL6 ACADM ACSL5 ACADS ACSS2 DECR1 LIPF LIPE GPD2 PNPLA2 CRAT ACAT1 DLD GCDH CHKB ECHS1 LPL LIPC FLUOROPYRIMIDINE ACTIVITY%WIKIPATHWAYS_20260710%WP1601%HOMO SAPIENS Fluoropyrimidine activity ERCC2 RRM1 ABCC5 ABCC3 CYP2A6 RRM2 CDA DPYS TYMP TDG FPGS UPP2 TK1 XRCC3 SMUG1 UCK2 UCK1 DPYD TYMS UMPS SLC29A1 DHFR SLC22A7 GGH CES2 ABCG2 CES1 MACROPHAGE MARKERS%WIKIPATHWAYS_20260710%WP4146%HOMO SAPIENS Macrophage markers CD163 CD74 CD14 CD83 CD68 LYZ F3 PANCREATIC ADENOCARCINOMA PATHWAY%WIKIPATHWAYS_20260710%WP4263%HOMO SAPIENS Pancreatic adenocarcinoma pathway VEGFA RPS6KB2 MAPK10 MAPK3 MTOR CASP9 RPS6KB1 RB1 STAT3 CDKN1A EGFR MAPK8 GADD45B GADD45G BAK1 CDKN2A E2F2 JAK1 E2F3 DDB2 dik HEL-S-34 POLK BAX RALBP1 BCL2L1 TGFBR1 RALA TGFBR2 PLD2 MAPK9 ERBB2 ARAF SMAD2 RAD51 EGF STAT1 SMAD4 CCND1 BRCA2 AKT3 GADD45A RAC1 BAD PIK3CD RAC3 PIK3R3 NFKB1 PIK3R1 MAP2K1 MAP2K2 CDK6 CHUK CDK4 IKBKB IKBKG RAF1 PIK3CA TGFA TGFB1 PIK3R2 RALB RELA PAK6 PAK1 PAK4 CDC42 MAPK1 INTRACELLULAR TRAFFICKING PROTEINS INVOLVED IN CMT NEUROPATHY%WIKIPATHWAYS_20260710%WP4856%HOMO SAPIENS Intracellular trafficking proteins involved in CMT neuropathy MFN2 RAB3B MPZ HEL-S-102 EGR2 PMP22 MTMR2 LRSAM1 RAB4A RAB4B HSPB8 NEFL LITAF RAB11A RAB11B FIG4 FGD4 SH3TC2 RAB25 KIF1B RABAC1 SBF2 RAB7A NOTCH SIGNALING%WIKIPATHWAYS_20260710%WP268%HOMO SAPIENS Notch signaling KAT2B PSEN2 DVL1 PSEN1 DVL2 KAT2A DVL3 RBPJ NCOR2 HDAC2 HDAC1 RBPJL MAML1 DTX1 NOTCH3 CTBP2 DTX2 NOTCH4 DTX3 DTX4 DLL4 LFNG APH1B KCNJ5 DTX3L CREBBP MFNG NUMB JAG2 MAML3 DLL3 CTBP1 NOTCH1 NOTCH2 HES1 HES5 ADAM17 S1P RECEPTOR SIGNAL TRANSDUCTION%WIKIPATHWAYS_20260710%WP26%HOMO SAPIENS S1P receptor signal transduction S1PR1 SPHK2 SPHK1 GNAI3 S1PR3 MAPK3 SMPD2 S1PR5 S1PR2 GNAI1 PLCB3 AKT3 PIK3C2B MAPK12 MAPK7 PLCB1 PLCB2 MAPK6 MAPK4 MAPK1 RAS SIGNALING%WIKIPATHWAYS_20260710%WP4223%HOMO SAPIENS Ras signaling NGFR MAPK10 GRB2 ZAP70 PRKCA RAB5A ARHA RASGRF1 NTRK1 PLA2G2A IGF1R FLT4 PLA2G1B FGFR1 KIT LAT EPHA2 RALBP1 FGFR3 RALA PLD2 CSF1R KDR PLCG1 RAC1 PIK3CD PIK3R3 PIK3R1 NRAS SYNGAP1 NTRK2 FGFR4 GRIN2B CALML6 FLT3 GRIN1 CALML3 CALML4 SHC2 ETS2 RAF1 RASSF1 PIK3CA HTR7 TIAM1 PLA2G10 NF1 RIN1 GNG10 PLA1A SHC4 PLA2G3 RASAL1 PLA2G5 GNG12 STK4 GNG11 RELA RASAL3 GNG13 FLT1 PLA2G6 RASGRP4 TTBK1 RASGRP3 PAK1 ABL2 GNGT2 AFDN RGL2 RASGRF2 MAPK1 PLA2G12A PLA2G4F RASA4B PLA2G12B PLA2G4D KSR1 MAPK3 PLA2G4E PLA2G4B PLA2G4C RRAS2 PRKCB PLAAT3 KSR2 RASA3 RASA4 RASA2 RAPGEF5 ARF6 SHOC2 PLA2G2F PLA2G2D PLA2G2E PLA2G2C PRKACG RRAS GNB2 CALM1 GNB4 GNB3 GNB5 EGFR MAPK8 PDGFRA GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 TNFSF6 PTPN11 SOS2 GAB2 BCL2L1 MAPK9 AKT3 BAD INSR RAC3 NFKB1 FOXO4 HRAS MAP2K1 PLCG2 MAP2K2 CHUK GNGT1 FGFR2 IKBKB GNB1 IKBKG SOS1 SHC3 SHC1 EXOC2 PIK3R2 RAP1A RALB PLCE1 PAK6 RAB5B RAB5C REL PAK4 CDC42 MESODERMAL COMMITMENT PATHWAY%WIKIPATHWAYS_20260710%WP2857%HOMO SAPIENS Mesodermal commitment pathway ZIC5 GDF3 NODAL FZD8 TCF4 TEAD2 LATS1 PRKAR1A FGFR1 FGF8 HTT LEFTY1 YAP1 NOG FOXH1 NR1B3 BMPR1A RARB LEFTY2 SMAD2 CCND1 INHBA SMAD6 BMP7 AMH FOXA1 KLF4 CRTC1 ACVR2B ACVR2A ACACA TRIM28 SNAI1 SOX21 SOX2 SOX17 BMPR2 SESN1 CEP250 CTBP2 RPL38 PITX2 HES7 NFE2L2 WDHD1 EMSY ADAM19 TWSG1 WDFY2 BCORL1 TOX GATA6 GATA3 DKK1 MBTD1 EPB41L5 UBR5 FZD5 ATP8B2 FZD4 PBX3 HMGA2 ZFHX4 PBX1 BHLHB2 EXT1 EXT2 NABP2 PLCH1 C1QBP TRIM71 BCAR2 SETD2 SCHIP1 SMAD1 PHF6 CSRP2 ZIC2 ZIC3 TRIM5 AXIN1 HNF4A JARID2 SLC2A12 NLK BMP4 MSGN1 LEF1 TET1 POU5F1 PARP8 TOX3 ARL4A AEBP2 AHDC1 C9orf72 FOXC2 CUL4B WNT3 FOXC1 WDCP ZNF462 ELP4 TBX3 TCF7L1 MEIS1 SMAD4 KLF5 RGS10 MIXL1 FOXA2 WNT3A TBX1 ARID5B VAV3 PIAS1 PPP2CA AXIN2 HAND1 TBX6 ACVR1 DNMT3B CCDC6 PHOTODYNAMIC THERAPY INDUCED HIF 1 SURVIVAL SIGNALING%WIKIPATHWAYS_20260710%WP3614%HOMO SAPIENS Photodynamic therapy induced HIF 1 survival signaling VEGFA BAX HEL-S-133P BCL2L1 BCL2A1 BNIP3 EGLN1 PFKL PTGS2 PMAIP1 BIRC5 HEL-S-30 SLC2A3 HIF1AN IGFBP1 IGFBP2 EDN1 NOS2 HEL-S-68p BAK1 MCL1 BNIP3L TGFA ANGPT1 HIF1A ANGPT2 EPO PDHA1 COMPLEMENT AND COAGULATION CASCADES%WIKIPATHWAYS_20260710%WP558%HOMO SAPIENS Complement and coagulation cascades THBD CFB CFH CFI HEL-S-78p KNG1 PLAT VWF BDKRB1 F2 SERPING1 KLKB1 F3 C1QB C1QA C1S C5AR1 C4B_2 C3AR1 CR2 SERPINA1 PROS1 CLTC C1QC CLU C8G SERPINF2 F5 F7 F8 F9 MASP2 MASP1 CD46 CFD CPB2 SERPINC1 PLG TFPI LMAN1 C6 F13B C7 C9 CD55 F10 SERPIND1 HEL-S-62p PROC CR1 PLAUR F2R TRANS SULFURATION ONE CARBON METABOLISM AND RELATED PATHWAYS%WIKIPATHWAYS_20260710%WP2525%HOMO SAPIENS Trans sulfuration one carbon metabolism and related pathways HEL-S-182mP HEL-S-44 GPX2 GPX4 GPX3 BAAT GPX1 HEL-75 PHGDH GCLC GCLM PSPH AMT HEL-S-75p ALDH7A1 GAD1 CEPT1 CHKB SHMT1 BCAT2 HEL-S-51e PEMT CBS CHPT1 HEL-S-64p PSAT1 CTH CDO1 AHCYL2 HEL-S-61p MTR AHCYL1 MAT1A SLC25A48 TYMS DNMT3L PCYT1B DHFR BHMT2 GPX6 MTHFD1L GPX7 MTHFD1 MTHFD2L MTHFD2 BCAT1 CHDH pcap DNMT3B CHKA AGXT2 GAD2 OSTEOARTHRITIC CHONDROCYTE HYPERTROPHY%WIKIPATHWAYS_20260710%WP5373%HOMO SAPIENS Osteoarthritic chondrocyte hypertrophy VEGFA opn COL1A1 ACAN FGFR3 COL10A1 CNMD P4HTM MAPK3 JUND GANC FOSL2 FOSB LAMTOR1 DDR2 IBSP PRKCA AKT3 KDR COL3A1 FGF23 NTRK1 NFKB1 FOSL1 CEBPB STAT3 NGF FGFR4 FGFR2 JUNB RUNX2 SOX9 PIK3CA VHL JUN FOS FGFR1 HIF1A RELA RELB CTGF COL2A1 MAPK1 SLC25A46 PATHWAY%WIKIPATHWAYS_20260710%WP5521%HOMO SAPIENS SLC25A46 pathway MFN1 MFN2 OPA1 APOOL MMGT1 IMMT TMEM85 COX4NB EMC10 MICOS13 MICOS10 APOO CHCHD3 CHCHD6 EMC1 EMC2 EMC3 EMC6 EMC7 DISORDERS IN KETONE BODY SYNTHESIS%WIKIPATHWAYS_20260710%WP5175%HOMO SAPIENS Disorders in ketone body synthesis BDH1 OXCT1 ACAT1 HMGCL CCL18 SIGNALING%WIKIPATHWAYS_20260710%WP5097%HOMO SAPIENS CCL18 signaling MMP2 CDH2 ZEB2 CCR8 AK4 PTK2B MELATONIN METABOLISM AND EFFECTS%WIKIPATHWAYS_20260710%WP3298%HOMO SAPIENS Melatonin metabolism and effects AANAT APOE PER1 ACHE ASMT FOXO1 CYP2C19 PRKCA SULT1A1 GSK3B EDN1 NFKB1 CALM1 ECE1 SIRT1 CAMK2A MAP2 PER2 MTNR1A PER3 MTNR1B CRY2 hCG_2014051 CRY1 MAOA CSNK1D IRAK1 CYP1A2 CYP1A1 CYP1B1 ADRB1 TRAF6 6Q16 COPY NUMBER VARIATION%WIKIPATHWAYS_20260710%WP5400%HOMO SAPIENS 6q16 copy number variation NTRK2 LEPR GHSR BDNF MC4R LEP NPY AgRP SIM1 POMC GHRL INSR INS SARS COV 2 REPLICATION ORGANELLE FORMATION%WIKIPATHWAYS_20260710%WP5156%HOMO SAPIENS SARS CoV 2 replication organelle formation PIK3R4 ROBO4 AND VEGF SIGNALING CROSSTALK%WIKIPATHWAYS_20260710%WP3943%HOMO SAPIENS ROBO4 and VEGF signaling crosstalk SLIT2 VEGFA SRC ROBO4 KDR RAC1 ARSENIC METABOLISM AND REACTIVE OXYGEN SPECIES GENERATION%WIKIPATHWAYS_20260710%WP5233%HOMO SAPIENS Arsenic metabolism and reactive oxygen species generation HEL-S-21 HEL-S-44 COA3 AS3MT ND1 UQCRFS1 ATP1A1 SDHA ALBUTEROL AND BUDESONIDE THERAPY FOR ASTHMA%WIKIPATHWAYS_20260710%WP5503%HOMO SAPIENS Albuterol and budesonide therapy for asthma CREB1 GNAS ADCY3 ADCY1 ADCY8 NR3C1 ADCY6 MYL4 ADCY5 PLCB3 PRKAR1B PLCB4 ADCY9 PRKAR1A PLCB1 PLCB2 MYL1 ADRB2 MYL2 MYL3 TRANSLATION FACTORS%WIKIPATHWAYS_20260710%WP107%HOMO SAPIENS Translation factors EEF1G EIF3S3 EIF4A2 EIF5 EIF2S3 EIF3S2 EEF1A2 EIF3J EIF3G EIF2B2 ETF1 EIF3E PABPC1 EIF3F EIF3C EIF3D EIF3A EIF3B EIF4E EIF5B EIF6 EIF2S1 EIF2B5 EIF4EBP1 EIF2AK2 PAIP1 GSPT2 EEF2 SUI1 EEF2K EEF1B2 EIF4H EIF4G1 EIF4EBP2 EIF3CL EIF4EBP3 EIF2B1 EIF5A EIF2B3 CLUH EIF1AY EIF4A1 EIF1AX EIF2AK1 EIF2S2 EIF4B EEF1A1 TOLL LIKE RECEPTOR SIGNALING RELATED TO MYD88%WIKIPATHWAYS_20260710%WP3858%HOMO SAPIENS Toll like receptor signaling related to MyD88 TBK1 IRF3 TICAM2 TICAM1 IKBKE TRAF3 NFKB1 NFKB2 TLR5 TLR4 CHUK IRAK4 IKBKB TIRAP TLR1 IRF7 TLR9 TLR7 TLR8 IKBKG TLR3 IRAK1 RELA RELB REL TRAF6 MYD88 MAPK1 INVOLVEMENT OF SECRETASE IN NEURODEGENERATIVE DISEASES%WIKIPATHWAYS_20260710%WP5372%HOMO SAPIENS Involvement of secretase in neurodegenerative diseases SRPK2 STAT1 SET NTRK2 TARDBP AKT3 BACE1 APP BDNF SNCA CEBPB INSULIN SIGNALING IN ADIPOCYTES DIABETIC CONDITION %WIKIPATHWAYS_20260710%WP3635%HOMO SAPIENS Insulin signaling in adipocytes diabetic condition IRS1 MTOR RPS6KB1 TBC1D4 INSR RPS6 SLC2A4 EMBRYONIC STEM CELL PLURIPOTENCY PATHWAYS%WIKIPATHWAYS_20260710%WP3931%HOMO SAPIENS Embryonic stem cell pluripotency pathways GRB2 LRP6 FZD1 FZD7 FZD8 FZD2 STAT3 FGFR1 FGF8 JAK1 NOG FGFR3 BMPR1A EGF LIF HNF1A SMAD6 GSK3B FZD9 FGF16 PTEN ACTR2 WNT9B PIK3CD ERAS FGF19 FGF21 FGFR4 RAF1 ACVR2B MAPK1 FGF3 FGF6 FGF9 MTOR FGF20 FGF22 FGF17 BMPR2 FGF14 FGF23 FGF18 FGF13 EGFR FGF12 DKFZp781O1323 FGF7 FZD5 MAP2K6 MAP2K3 FZD4 PDGFRA WNT2B JUN LRP5 FOS MAPK12 SMAD1 SMAD9 WNT5B PDGFA FGF4 AXIN1 WNT16 PTPN11 BMP4 FGF10 IL6ST DVL1 DVL2 DVL3 WNT1 WNT3 ARAF WNT4 WNT10B WNT10A SMAD4 AKT3 WNT3A WNT7B WNT7A FGF2 HRAS APC MAP2K1 MAP2K2 MDM2 FGFR2 SELENOP SOS1 PIK3R2 MAPK7 MAPK6 MAPK4 MAP2K5 ACVR1 FZD3 POLYCYSTIC KIDNEY DISEASE PATHWAY%WIKIPATHWAYS_20260710%WP2571%HOMO SAPIENS Polycystic kidney disease pathway MAPK3 FZD1 MTOR FZD7 FZD8 PRKACG SFRP4 FZD2 IGF1R GNA11 STK11 FZD5 FZD4 WNT2B ADCY6 JUN FOS MYC WNT5B IGF1 WNT16 GNAI3 ERBB2 DVL1 DVL2 DVL3 WNT1 TNF WNT3 RPS6KA1 WNT4 GNAI1 WNT10B WNT10A EGF TSC2 CCND1 GSK3B KDR PRKAA1 FZD9 PRKAA2 WNT3A PRKAG1 WNT9B WNT7B FZD10 WNT7A PRKAG2 PKD1 TSC1 WNT9A HRAS SSTR2 CFTR PRKAG3 PDE1A WNT8B NRAS PLCG2 MAP2K2 KCNN4 SLC12A2 PRKAB2 IKBKB VEGFB PRKAB1 GNAS RHEB SRC FLT1 WNT8A FZD3 GPCRS CLASS A RHODOPSIN LIKE%WIKIPATHWAYS_20260710%WP455%HOMO SAPIENS GPCRs class A rhodopsin like MTNR1A MTNR1B GHSR MC4R CXCR4 DRD2 SSTR2 NPFFR2 OXTR NPFFR1 RRH HTR4 GRPR GPR174 GPR173 EDNRA KPG_010 HTR6 EDNRB GPR171 KPG_011 CMKLR2 LPAR4 PTGDR GPR37L1 FPRL2 TRHR GPR161 PTGFR FPR1 OR1I1 MC2R GALR3 GALR2 NPBWR1 GALR1 NPBWR2 OR6B1 NTSR1 NTSR2 GPR17 OR2J3 OR2J2 OR2J1 NMBR RGL4 CHRM2 OR6A2 CHRM1 OR7C2 OR7C1 GPR18 GPR19 OR10J1 GPR27 GPR25 PTGDR2 GPR22 BRS3 CCKAR OPN1LW IL8RB GPR39 OR5F1 GPR37 GPR34 FFAR1 AVPR1B GPR31 AVPR1A MC3R OR5V1 OPN1MW CCKBR ADRB3 FSHR OR3A3 OR3A2 OR3A1 PTGER4 OPRD1 OR10H1 OR10H3 GPR45 PTGER1 OR10H2 PTGER2 PTGER3 GPR42 OR2AG1 CHML P2RY13 P2RY10 P2RY11 P2RY14 GPR52 GPR50 CCR6 GPR4 CCR5 GPR3 GPR6 MAS1 MC5R F2RL1 OR1C1 GPR68 CHRM4 GPR65 CHRM5 CXCR1 NPY2R GPR63 CCRL2 OR2D2 LHCGR NPY1R GPR75 OR2T1 OR1A2 OR1A1 OR2C1 SUCNR1 HTR2B CCR1 OR5I1 C5AR2 CXCR3 GPR87 CCR7 GPR85 GPR83 CCR4 MCHR1 OR2S2 CCR3 HCAR3 CCR2 OR1Q1 HRH1 HCAR1 HRH2 DRD1 OR2B6 DRD3 DRD4 OR2B3 DRD5 OR2B2 OPN4 OPN3 NMUR2 NMUR1 OR2A4 OR7A10 OR14J1 MLNR OR1G1 ADRA1B ADRA1A PRLHR OR8D2 OR7A17 PTGIR NPY5R OR1F1 OR2H2 OR2H1 AVPR2 OPRM1 SSTR3 RHO SSTR4 SSTR5 ADORA2B OR7A5 OR10A4 OR10A5 OR1E2 OR1E1 NPY4R P2RY6 CCR10 CNR2 P2RY4 XCR1 OR8B8 CNR1 P2RY2 GPR32 OR2W1 P2RY1 FPR2 OR12D3 OR1D5 MAS1L OR1D2 OR2F2 OR2F1 OPRK1 HTR5A HCRTR2 HCRTR1 OPN1SW ACKR2 OR11A1 HTR2A CCR8 HTR1E HTR1F HTR1D HTR1A HTR1B CXCR5 FFAR3 FFAR2 TBXA2R CHRM3 CX3CR1 HTR7 ACKR4 ACKR3 ADRA1D ADRB1 ADRB2 ADRA2C ADRA2B ADRA2A F2R F2RL2 F2RL3 MC1R BDKRB2 AGTR1 BDKRB1 AGTR2 LTB4R CMKLR1 HRH3 C3AR1 ADORA2A GPER 13Q12 OR CRYL1 COPY NUMBER VARIATION %WIKIPATHWAYS_20260710%WP5405%HOMO SAPIENS 13q12 or CRYL1 copy number variation HEL30 INTERFERON SIGNALING IN TUBERCULOSIS%WIKIPATHWAYS_20260710%WP4197%HOMO SAPIENS Interferon signaling in tuberculosis IRF-1 TYK2 IFITM1 IFNGR1 PIAS1 OAS1 STAT2 IFIT1 IFNGR2 IFNAR1 STAT1 IRF9 IFI35 PSMB8 IFIT3 SOCS1 JAK1 MX1 IFNG IFNAR2 METABOLISM OF TETRAHYDROCANNABINOL THC %WIKIPATHWAYS_20260710%WP4174%HOMO SAPIENS Metabolism of tetrahydrocannabinol THC CYP3A4 CYP2C9 EBOLA VIRUS INFECTION IN HOST%WIKIPATHWAYS_20260710%WP4217%HOMO SAPIENS Ebola virus infection in host CAV2 PS1TP5BP1 IRF3 RAB5A ARHA CLEC4M IKBKE CLEC10A ICAM2 ICAM3 HLA-DOA NPC1 HLA-DOB CLTB VPS39 KPNA1 NPC2 TLR4 VPS41 CD300A TIMD4 HLA-A HLA-F IGF1R HLA-G CTSL HLA-E TYRO3 TSG101 SCIN CLTCL1 HLA-DQA2 HLA-DQA1 CD209 IQGAP1 CLEC6A CLTA HLA-C ASGR1 HAVCR1 HLA-DPA1 MFGE8 HLA-DQB2 HLA-DQB1 HLA-DMA HLA-DMB FLNB DAB2IP MERTK AXL NEDD4 HLA-DPB1 RAB9A FOLR1 HLA-B STAT1 EP300 RAC1 PIK3CD PIK3R3 EIF2S1 PIK3R1 EIF2AK2 PIK3CA TIAM1 RELA ACTN1 RELB PAK1 MAPK1 MAPK3 TBK1 VPS18 RASA2 VPS16 HLA-DRB5 CREBBP EGFR TFAP2A BST2 HAVCR2 IRF7 HLA-DRB1 C1QBP RFC1 SOCS3 FLNA ADAM17 ITGB3 ITGAV NFKB1 CLTC NFKB2 MBL2 ITGA4 VPS33A ITGA2 ITGA1 VAV2 ITGA6 IL4 PIK3R2 ITGB1 RHOB RAB7A VPS4A REL ACTG1 ACTN4 CAV3 RIGI CDC42 NEURODEGENERATION WITH BRAIN IRON ACCUMULATION NBIA SUBTYPES PATHWAY%WIKIPATHWAYS_20260710%WP4577%HOMO SAPIENS Neurodegeneration with brain iron accumulation NBIA subtypes pathway WDR45 DCAF17 PIK3R4 SPTLC1 WIPI2 C19orf12 ATG14 CP ATG16L1 MLST8 COASY FA2H WIPI1 ATG2A FTL AKT1S1 RPTOR TSC2 MTOR MAP1LC3A PRKAA1 TSC1 DEPTOR DKFZp686F0183 RB1CC1 ATG3 STK11 ATG10 ATG12 ULK1 RHEB ATG101 ACACA PLA2G6 PANK2 SARS COV 2 ALTERING ANGIOGENESIS VIA NRP1%WIKIPATHWAYS_20260710%WP5065%HOMO SAPIENS SARS CoV 2 altering angiogenesis via NRP1 VEGFA ACE2 NRP1 KDR FURIN PTDINS 4 5 P2 IN CYTOKINESIS PATHWAY%WIKIPATHWAYS_20260710%WP5199%HOMO SAPIENS PtdIns 4 5 P2 in cytokinesis pathway ARHA HEL70 SEPTIN2 MYL2 RDX RAB35 KIF23 EZR OCRL CIRCADIAN RHYTHM GENES%WIKIPATHWAYS_20260710%WP3594%HOMO SAPIENS Circadian rhythm genes AANAT NGFR MAPK10 JUND TPH1 GHRH ATF4 HCRTR2 HCRTR1 GHRL NTRK1 PER2 MTNR1A PER3 MTNR1B CRY2 PHLPP1 STAR AgRP ADCY1 GFPT1 NR1C1 PROK2 MAGED1 DDC C1orf51 RORA NCOR1 CCAR2 PPP1CC GSK3B GIG8 EP300 PRKAA1 HEL-S-80p PRKAA2 BTRC PTEN PROK1 DRD2 CHRNB2 UTS2R FBXW11 UBE3A KCNH7 USP2 METTL3 DYRK1A SIRT1 SOX14 CARTPT SLC9A3 CLDN4 CREB1 NOS2 PSPC1 TIMELESS HOMER1 UTS2 SIK1 ATF5 UBC KMT2A CREM NR1H3 RAI1 NKX2-1 ZFHX3 HTR7 NR1D1 BTBD9 SETX CRTC1 ID4 HNRNPD ID3 FBXL3 TCF2 OGT MTTP ADA EZH2 KDM5A SUV39H2 RELB SUV39H1 HEBP1 RBM4 DBP SIN3A SIX3 HEL-S-2 KLF10 KCND2 SFTPC CPT1A PAX4 PROX1 SFPQ CHRM1 THRAP3 KCNMA1 CRH AVP NLGN1 CIPC CRX RBM4B NPS SKP1 ATOH7 PROKR1 NFIL3 HDAC2 NOCT RPS27A ARNT2 HDAC1 NTRK3 CAVIN3 DDX5 PRKDC PASD1 PML BHLHE41 MYBBP1A RORB MC3R KLF9 EGR1 BMAL2 MAPK8 GNA11 CRY1 JUN BHLHB2 TNFRSF11A PRF1 NPAS2 IL6 NR1D2 HS3ST2 NPY2R RORC TOP2A PER1 MAPK9 TPH2 NR2F6 LEP PPARGC1A ADORA2A NAMPT TH AHR DRD1 DRD3 DRD4 F7 PPARG OPN4 OPN3 CDK4 HDAC3 hCG_2014051 CSNK1D TYMS ROCK2 MAGEL2 MIR 124 PREDICTED INTERACTIONS WITH CELL CYCLE AND DIFFERENTIATION %WIKIPATHWAYS_20260710%WP3595%HOMO SAPIENS mir 124 predicted interactions with cell cycle and differentiation STRADB PRKAA1 STK11 PTBP1 SIX4 CTDSP1 NEURAL CREST CELL MIGRATION DURING DEVELOPMENT%WIKIPATHWAYS_20260710%WP4564%HOMO SAPIENS Neural crest cell migration during development NGFR PIK3R4 PIK3R5 F2RL2 TRIO AKT3 RAC1 ARHA PIK3CD PIK3R3 EPHB2 EPHB4 STAT3 TWIST1 EPHB6 ARF1 EPHB1 EPHB3 BDNF PIK3CA TIAM1 JUN MMP2 FOS CDH11 PAK6 PAK1 PAK4 MMP9 POST COVID NEUROINFLAMMATION%WIKIPATHWAYS_20260710%WP5485%HOMO SAPIENS Post COVID neuroinflammation ACE2 GFAP IL1A TMPRSS2 FURIN TLR7 TLR8 IL10 TNF TLR3 IL4 IL12A HMGB1 IL2 IL1B IFNA2 CXCL8 IL18 IL6 IFNG CCL11 MAPK1 TLR4 GENE REGULATORY NETWORK MODELING SOMITOGENESIS %WIKIPATHWAYS_20260710%WP2854%HOMO SAPIENS Gene regulatory network modeling somitogenesis MESP2 EPHA4 WNT3A RIPPLY2 TBX6 FGF8 HES1 HES7 LFNG NOTCH1 METABOLIC REPROGRAMMING IN COLON CANCER%WIKIPATHWAYS_20260710%WP4290%HOMO SAPIENS Metabolic reprogramming in colon cancer HEL-S-133P PFKL HEL107 PSAT1 HEL-S-30 ENO1 ACLY FASN HK3 HEL-S-162eP PSPH FH PGAM1 HEL-S-68p SLC16A3 TIGAR PYCR2 GLUD1 ALDOB GOT2 PAICS SDHB SUCLG2 ACO2 RPIA HEL-S-51e PDHA1 GLS MDH2 HAIR FOLLICLE DEVELOPMENT ORGANOGENESIS STAGE 2 OF 3%WIKIPATHWAYS_20260710%WP2839%HOMO SAPIENS Hair follicle development organogenesis stage 2 of 3 SHH LEF1 BMP4 SNAI1 LAMA5 SMO EDAR FZD1 CCND1 INHBA NFKB1 FGFR2 RUNX2 PDGFRA FOXI3 LRP5 NCAM1 TP63 TNLG7C PTCH1 ITGB1 GTPBP4 GJB6 CCND2 MYC PDGFA PHOSPHOINOSITIDES METABOLISM%WIKIPATHWAYS_20260710%WP4971%HOMO SAPIENS Phosphoinositides metabolism PIP4P1 PIP4K2A PIK3R4 PIP4K2B PIP5K1C SBF1 SACM1L PIKFYVE PLCH2 MTMR2 PLCD3 PLCD4 INPP5D OCRL PLCB3 PLCB4 PLCG1 PTEN SBF2 PLCB1 PIK3CD PLCB2 PLCG2 STM7 PIK3CA PIP5K1A PIK3C2G PIK3C2B PLCH1 MTMR1 MTMR10 MTMR3 PLCE1 MTMR12 MTMR11 MTMR8 MTMR9 MTMR4 MTMR6 MTM1 PIP4P2 CELL TYPE DEPENDENT SELECTIVITY OF CCK2R SIGNALING%WIKIPATHWAYS_20260710%WP3679%HOMO SAPIENS Cell type dependent selectivity of CCK2R signaling CCK CNR1 RYR1 RYR2 PLCB1 RYR3 DAGLA TRPC1 GNAI1 CCKBR SPHINGOLIPID METABOLISM IN SENESCENCE%WIKIPATHWAYS_20260710%WP5121%HOMO SAPIENS Sphingolipid metabolism in senescence CDKN1A SPTLC1 CDK4 S1PR1 CDK2 SPHK1 S1PR5 S1PR2 PRKCB SGMS2 PRKCA SGPP1 UGCG TERT MTOR DEGS1 KDSR RPP38 CERS2 PLCB1 RB1 GLB1 MAPK1 IRON METABOLISM IN PLACENTA%WIKIPATHWAYS_20260710%WP2007%HOMO SAPIENS Iron metabolism in placenta SLC11A2 HEL60 STEAP3 HEPHL1 TF TFRC TFR2 IREB2 SLC40A1 MCOLN1 HAMP GLYCOLYSIS IN SENESCENCE%WIKIPATHWAYS_20260710%WP5049%HOMO SAPIENS Glycolysis in senescence HEL-S-30 HEL-S-133P PRKAA1 ENO1 HEL-S-68p RB1 HEL-S-162eP 15Q25 COPY NUMBER VARIATION%WIKIPATHWAYS_20260710%WP5408%HOMO SAPIENS 15q25 copy number variation NMBR SPCS1 EGF SH3GL3 RAMAC ZNF592 RNMT BNC1 AGAP2 TENT4B BTBD1 GOLGA6L4 ADAMTSL3 C15orf40 RYR1 FSD2 RYR2 AP3S1 WHAMM PDE8A SEC11A NMB RAF1 HOMER2 AP3D1 WDR73 AP3B2 DNM3 SHANK3 SPCS3 SPCS2 SYNJ1 ALPK3 ZSCAN2 SHANK1 HTT MODULATORS OF TCR SIGNALING AND T CELL ACTIVATION%WIKIPATHWAYS_20260710%WP5072%HOMO SAPIENS Modulators of TCR signaling and T cell activation RPRD1B NFKBIA SH2B3 MEF2D SH2D1A ARHH FIBP GRB2 CD5 AGO1 ZAP70 LCK RASA2 MAP3K14 CD3G CDKN1B CD3E VAV1 PRKCQ GNA13 PTPN6 LCP2 LAT SOCS1 TRAF6 PLCG1 NFKB1 CD3D PIK3R1 TNFAIP3 GRAP2 BCL10 PDPK1 CHUK IKBKB CD8A MAP3K8 CARD11 IKBKG PIK3R2 MAP4K1 RELA ITK DGKA TMEM222 ARIH2 UBASH3A DGKZ REL NDUFB10 CUL5 RNF7 MIRNA DEGRADING ENZYMES%WIKIPATHWAYS_20260710%WP4316%HOMO SAPIENS miRNA degrading enzymes EXOSC4 PNPT1 XRN1 COVID 19 AND ENDOTHELIAL CELL SENESCENCE%WIKIPATHWAYS_20260710%WP5256%HOMO SAPIENS COVID 19 and endothelial cell senescence IL17RC IL17RA TLR4 IL17A PLATELET MEDIATED INTERACTIONS WITH VASCULAR AND CIRCULATING CELLS%WIKIPATHWAYS_20260710%WP4462%HOMO SAPIENS Platelet mediated interactions with vascular and circulating cells VCAM1 TLR7 SELPLG TGFB1 SELE CD40LG PF4 CD40 IL1B SELP CCL5 CCL2 TLR4 SEBALEIC ACID FORMATION AND METABOLISM%WIKIPATHWAYS_20260710%WP5315%HOMO SAPIENS Sebaleic acid formation and metabolism CYP4F3 ACSL1 FADS2 FADS1 ALOX5 COHESIN COMPLEX CORNELIA DE LANGE SYNDROME%WIKIPATHWAYS_20260710%WP5117%HOMO SAPIENS Cohesin complex Cornelia de Lange syndrome SMC3 PTTG1 CDCA5 PDS5B PDS5A AURKB PTPA NIPBL SGOL1 WAPAL ESCO1 PPP2R1A ESCO2 REC8 MAU2 STAG3 PPP2R5D SMC1A APC RAD21 CDC2 PLK1 PPP2R5B PPP2R5A STAG2 PPP2CA PPP2R1B SMC1B ESPL1 PPP2R5E HDAC8 PPP2R5C FOCAL ADHESION PI3K AKT MTOR SIGNALING%WIKIPATHWAYS_20260710%WP3932%HOMO SAPIENS Focal adhesion PI3K Akt mTOR signaling COL4A4 FOXO1 LAMA5 VTN LAMB2 ATF4 PELO HIF3A STRADA CAB39 PFKFB1 PFKFB4 ELAVL1 RAB10 PIK3IP1 LPAR1 IGF1R FLT4 ANGPT1 FGFR1 KIT EIF4E1B FGF8 EPHA2 FGFR3 TNC LAMA4 FGF16 XB LAMC1 THBS2 COL3A1 COL4A2 COL4A1 INS COL5A3 COL5A2 FGF19 IRS4 FGF21 NOS2 FGFR4 TCL1B TCL1A PPP2R1B KPG_010 CDC37 LPAR2 LPAR3 LPAR4 GNG10 PDGFD GYS1 PDGFC GNG12 GNG11 GNG13 GYS2 GNGT2 COL2A1 PHLPP2 RPS6KB2 RELN OSM CSHL1 GHB3 CHRM2 CHRM1 FGF3 COMP FGF6 FGF9 IBSP TNR RAB2A DDIT4 COL4A6 EFNA5 EFNA4 CASP9 CHAD FGF20 FGF22 FGF17 EFNA1 EFNA3 CSF1 FGF14 EFNA2 GNB2 FGF18 GNB4 GNB3 FGF13 FGF12 HSP90AB1 LAMC2 VWF PPP2R5B PPP2R5A ATF6B LAMA1 LAMA3 THBS4 THBS3 GNG3 GNG2 GNG5 GNG4 PPP2R3C GNG7 GNG8 ANGPT4 ANGPT2 LAMB3 LAMB1 PPP2R3A PPP2R2C IGF1 PPP2R2B PPP2R2D IL6R IFNB1 ITGAM ITGB4 ITGA2B PPARGC1A ITGAE AKT3 PPP2R1A ITGAX ITGB8 RAB8A ITGAV FGF2 ITGB7 PPP2R5D ITGB6 HRAS MAP2K1 MAP2K2 ITGA4 PDPK1 ITGA2 FGFR2 PPP2CA ITGA7 ITGA6 SOS1 PIK3R2 COL11A2 NGFR GRB2 MLST8 AKT1S1 SLC2A2 RAB14 SLC2A3 PRL EIF4E PHLPP1 LIPE STK11 CSF3 JAK1 CSF3R EPO opn CRTC2 THBS1 PRLR SLC2A4 CSF1R RAB11B EGF RPTOR CREB3 CREB3L3 KDR GSK3B CREB3L4 PRKAA1 CREB3L2 PRKAA2 PTEN CREB5 RPS6 PIK3CD TSC1 IL7R PIK3R1 GHR NRAS KITLG FOXA1 EIF4EBP1 CREB1 NGF IL3RA ULK1 RAF1 PIK3CA RHEB PFKFB2 HIF1A IL2RA IL2RB ACACA FLT1 HGF F2R MAPK1 OSMR VEGFA COL1A1 COL1A2 MAPK3 EPOR MTOR RPS6KB1 IFNA7 ATF2 IFNAR2 CDKN1A EGFR FGF7 IFNAR1 PDGFRA CDKN1B IRS1 PIK3C2B IL2 IL2RG PPP2R5E FOXO3A PDGFA JAK3 FGF4 PPP2R5C PIK3R4 FGF10 PIK3R5 ITGB3 TSC2 BAD INSR MDM2 GNGT1 IKBKB VEGFB VEGFC VEGFD GNB1 IKBKG ITGB1 HEL-S-125m EIF4B DOWNREGULATION OF ACE2 BY SARS COV 2 SPIKE PROTEIN%WIKIPATHWAYS_20260710%WP4799%HOMO SAPIENS Downregulation of ACE2 by SARS CoV 2 spike protein ACE2 AGTR1 AGTR2 HEMOGLOBIN SWITCHING EMBRYONIC FETAL AND ADULT%WIKIPATHWAYS_20260710%WP5605%HOMO SAPIENS Hemoglobin switching embryonic fetal and adult HBZ tal-1 HBG2 LDB1 HBG1 LMO2 HBE1 HBA2 GATA1 HBB HBD APOPTOSIS%WIKIPATHWAYS_20260710%WP254%HOMO SAPIENS Apoptosis NFKBIA MAPK10 IRF6 IRF3 BIRC5 TRADD CASP9 CASP8 CASP3 CYCS RIPK1 FADD BIRC3 IGF1R BCL2L11 TNFSF10 IRF7 BAK1 HRK MCL1 CASP6 CASP10 CASP4 MAP2K4 DFFB HELLS JUN DFFA CDKN2A TP63 SCAF11 TRAF2 DIABLO PRF1 BBC3 CRADD NFKBIB TNFRSF1A MYC TNFSF6 IGF1 IRF-1 BCL2 BAX BCL2L1 IRF4 IRF2 PMAIP1 BCL2L2 TNF BOK BIRC2 MAP3K1 APAF1 BAD TRAF1 TNFRSF1B TRAF3 TNFRSF10B NFKBIE NFKB1 PIK3R1 CASP2 MDM2 TP73 CHUK IKBKB LTA TNFRSF25 IKBKG TNFRSF21 BNIP3L IGF2 RELA EUKARYOTIC TRANSCRIPTION INITIATION%WIKIPATHWAYS_20260710%WP405%HOMO SAPIENS Eukaryotic transcription initiation POLR2J TBP POLR2K CDK7 POLR3B POLR3D TAF7 TAF6 POLR3H ERCC2 TAF5 POLR3K MNAT1 POLR1A POLR1D POLR3E GTF2F2 TAF12 HEL-S-28 TAF13 CCNH GTF2H2C_2 GTF2B TAF9 GTF2E1 GTF2E2 POLR2A GTF2H2 POLR2B GTF2H3 POLR2C GTF2H4 POLR2F POLR2G POLR2H POLR2I 2Q13 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260710%WP5222%HOMO SAPIENS 2q13 copy number variation syndrome GRB2 IL36G POLR1A IL1F10 POLR1C POLR1D ARF6 ANAPC1 CSF1 BCL2L11 IL1A GATA3 CSF2 IL37 IL2 SOCS3 MERTK SOCS1 IL6 POLR2F POLR2H POLR2K CHTM1 ZC3H8 PSD4 ARL14 CKAP2L POLR1F IL1R1 POLR1G POLR1H STAT1 FBLN7 IL36RN TMEM87B SLC20A1 RGPD8 RAC1 TULP1 TTL IL1B NT5DC4 POLR2L CXCL13 PLCG2 IL23A IL1RL2 IL1RN IL36A IL36B MAPK1 15Q13 3 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260710%WP4942%HOMO SAPIENS 15q13 3 copy number variation syndrome FANCD2 CREBBP GOLGA8H CHRFAM7A FAN1 KAT2B GPR75 FYN GRM6 MTMR10 GOLGA8R ARHGAP11B KLF13 OTUD7A CHRNA7 GOLGA8O GOLGA8Q CCL5 TRPM1 PYRIMIDINE METABOLISM%WIKIPATHWAYS_20260710%WP4022%HOMO SAPIENS Pyrimidine metabolism PNPT1 POLR1A PRIM2 POLR1C PRIM1 POLR1D POLA1 POLA2 ENPP1 RRM2 CDA DPYS TYMP TK1 UCK2 POLE UCK1 DPYD UMPS POLR2A POLR2B POLR2C POLR2G POLR2H POLR2I POLR2J POLR2K POLE4 POLR3B POLE2 POLR3D POLE3 POLR3H POLR3K POLD3 POLD4 RRM1 POLR1F NME2 POLD2 POLR1H RRM2B POLR2L POLR3E ENPP3 HEL74 ENTPD1 ENTPD3 CAD NME3 CTPS2 NME4 DCTD NME6 NME7 CMPK1 CMPK2 UPRT DCTPP1 DTYMK TYMS POLR2D POLR2J3 DUT POLR2J2 POLR3GL DHODH POLR3A POLR3C POLR3F POLR3G CALCIUM REGULATION IN CARDIAC CELLS%WIKIPATHWAYS_20260710%WP536%HOMO SAPIENS Calcium regulation in cardiac cells GJB1 YWHAQ PRKCA CAMK2D PRKD1 GNAO1 GJA5 ADCY3 ADCY1 ADCY8 PRKCE ADCY6 PRKAR1B ADCY5 PRKAR1A PRKCQ RGS14 CHRM3 GNAI3 GNAI1 FKBP1A RGS16 ATP1B2 CACNA1C KCNJ5 RYR1 RYR2 RYR3 ATP2A2 SLC8A1 GJA1 GNG12 GNG11 GNG13 ADRA1D ADRB1 ORAI1 ADRB2 CACNB1 CACNB3 RGS4 RGS5 RGS2 GJA3 RGS1 GJA4 GJA9 HEL2 GJA8 CHRM2 RGS6 CHRM1 ATP1B3 ATP1B1 DKFZp686L0365 STIM2 PRKCB GNAZ CACNA1B CACNA1A CACNA1S ITPR2 GJC1 GJC2 GRK5 GRK4 PLCB3 PKIB ADCY9 GJB2 GJB4 GJB3 PKIA FXYD2 CAMK4 GJB5 PKIG ANXA6 GJD2 CAMK1 GNB2 CALM1 CASQ2 CASQ1 GNB4 RGS18 GNB3 ADRB3 RGS17 CAMK2A GNB5 ATP1A4 SFN PLN RGS20 CAMK2G GNA11 KCNJ3 KCNB1 ATP2B3 ATP2B2 ATP2B1 RGS11 HEL-S-1 YWHAG GNG3 GNG2 GNG5 GNG4 GJB6 GNG7 GNG8 CHRM4 CHRM5 RGS10 PRKCH PRKCZ GNGT1 GNB1 GNAS ADRA1B ADRA1A HEL-S-99n HEL-S-93 COPPER HOMEOSTASIS%WIKIPATHWAYS_20260710%WP3286%HOMO SAPIENS Copper homeostasis HEL-S-44 BACE1 APP FOXO1 ATP7B SLC31A1 SLC11A2 CCND1 ATP7A GSK3B STEAP3 CASP3 PTEN APC MDM2 SP1 ADAM9 STEAP4 COX17 MT2A PIK3CA COX11 PRNP JUN SLC31A2 COMMD1 MT4 MT3 ADAM10 ATOX1 CCS MT1A SCO1 MTF1 MT1F MT1G FOXO3A MT1B XAF1 STEAP1 STEAP2 ADAM17 MT1E INTERLEUKIN 1 INDUCED ACTIVATION OF NF KB%WIKIPATHWAYS_20260710%WP3656%HOMO SAPIENS Interleukin 1 induced activation of NF kB AJUBA IL1A HEL-S-71 NFKB1 PRKCZ IRAK1 TRAF6 SQSTM1 TIFA UBE2V1 MIRNA BIOGENESIS%WIKIPATHWAYS_20260710%WP2338%HOMO SAPIENS miRNA biogenesis XPO5 DGCR8 DROSHA TARBP2 RAN DICER1 FBXL10 ENHANCEMENT OF MAP ERK SIGNALING IN DIFFUSE LARGE B CELL LYMPHOMA%WIKIPATHWAYS_20260710%WP4553%HOMO SAPIENS FBXL10 enhancement of MAP ERK signaling in diffuse large B cell lymphoma H2AZ2 MACROH2A2 H3F3B MAPK3 SUZ12 H2AB3 RNF2 H2AJ PCGF1 BCOR EED H2AX H2AB1 EZH2 H3C15 H2AZ1 BCL6 H3C8 MAPK1 CYCLIN DEPENDENT KINASE 4 6 INHIBITORS IN BREAST CANCER%WIKIPATHWAYS_20260710%WP5497%HOMO SAPIENS Cyclin dependent kinase 4 6 inhibitors in breast cancer PIK3R4 PIK3R5 CDK2 ERBB2 MAPK3 RPTOR MTOR CCND1 AKT3 PIK3CD PIK3R3 INS HRAS PIK3R1 NRAS CDKN1A EGFR CDK6 CDK4 IGF1R CCNE1 RAF1 PIK3CA CDKN1B IRS1 PIK3C2G PIK3R2 PIK3C2B MAPK1 CAFFEINE AND THEOBROMINE METABOLISM%WIKIPATHWAYS_20260710%WP3633%HOMO SAPIENS Caffeine and theobromine metabolism NAT2 CYP1A2 CYP2A6 XDH LUNG FIBROSIS%WIKIPATHWAYS_20260710%WP3624%HOMO SAPIENS Lung fibrosis HMOX1 SFTPC CXCL2 CCL4 CCL3 EDN1 NFE2L2 CEBPB GREM1 CMA1 FGF7 CALCA MT2A CSF2 MMP2 CSF3 IL6 PDGFA CCL11 IGF1 opn TIMP1 FAM13A TNF SKIL ELMOD2 ATP11A RTEL1 TERT DPP9 EGF STN1 MUC5B PTX3 SFTPA1 CCR3 CCR2 IL1B BMP7 SERPINA1 FGF2 CXCL8 CCL2 IL12B IL13 TGFA IL4 SFTPA2 IL5 KPG_011 TGFB1 CTGF HGF CCL5 MMP9 OXIDATIVE STRESS RESPONSE%WIKIPATHWAYS_20260710%WP408%HOMO SAPIENS Oxidative stress response HMOX1 CYBB HEL-S-44 MAPK10 MGST1 GSTT2 GPX3 TXN2 NQO1 TXNRD2 NOX5 GPX1 HEL-75 NFKB1 NOX3 GCLC NFE2L2 SP1 JUNB MAOA UGT1A3 FOS CYP1A1 NOX4 MAPK14 XDH TNF ALPHA SIGNALING%WIKIPATHWAYS_20260710%WP231%HOMO SAPIENS TNF alpha signaling NFKBIA KSR1 MAPK3 GRB2 TBK1 KSR2 RIPK3 TRADD SKP1 CASP9 CASP8 CASP3 CYBA RIPK1 FADD BIRC3 CREBBP MAPK8 PLK1 MAP3K14 TANK MAP3K5 MAP2K6 MAP2K3 MAP2K4 JUN TRAF2 DIABLO NFKBIB TNFRSF1A MAP3K7 BAX BCL2L1 MAPK9 TNF BIRC2 MAP3K1 APAF1 RAC1 BAD BTRC TRAF1 TNFRSF1B OTUD7B PYGL NFKBIE PSMD2 FBXW11 NFKB1 PTPRCAP NFKB2 HRAS NSMAF TAB3 TXN PRKCZ TNFAIP3 RFFL NRAS CHUK MAP3K7IP1 IKBKB SMPD2 MAP3K8 MADD PPP2CA IKBKG CDC37 SOS1 RAF1 CSNK2A1 PIG59 MAP4K2 REL MAPK1 NF1 COPY NUMBER VARIATION SYNDROME %WIKIPATHWAYS_20260710%WP5366%HOMO SAPIENS NF1 copy number variation syndrome NGFR CCNE2 MAPK3 TUBB ARF6 ARHA H3C15 EGFR H4C9 HIST1H4L ATR CRY1 MCL1 EED HEL-S-15 RFC3 RFC4 RFC2 CCNA2 JARID2 BCL2 PER1 SUZ12 IFNB1 RAB11A RAD51 EIF3A EGF SYN1 MAP3K1 SDC2 EXOC8 WDR48 HOXA9 OMG POLRMT PCNA NGF MYT1 EVL CCNE1 RTN4R INPP5A USP1 HOXA1 RBBP7 EXOC4 E2F6 EXOC3 RAB11FIP4 EXOC6 SOS1 RAF1 TEFM EXOC5 UTP6 ATAD5 LIMK1 SUPT5H NF1 EXOC2 COPRS EVI2A CENTA2 EXOC1 CRLF3 EVI2B EZH1 METAP2 EXOC7 ROCK2 RAD9A MAVS MAP3K2 H3C8 MAPK1 RIGI HEPATITIS C AND HEPATOCELLULAR CARCINOMA%WIKIPATHWAYS_20260710%WP3646%HOMO SAPIENS Hepatitis C and hepatocellular carcinoma VEGFA LEF1 CXCR1 BCL2L1 IL6R TGFBR1 MAPK3 GRB2 PTGS2 BIRC5 CASP9 SMAD4 CCND1 CASP3 HNF1A RAC1 BIRC3 NFKB1 COL4A2 CXCL8 RRM2 STAT3 CDKN1A BRCA1 MAPK8 NOS2 VAV2 SOS1 TGFB1 JUN MAPK14 HIF1A FRZB MYC MYOF E2F2 HEL-117 JAK1 IL6 CD44 TNFSF6 PTPN11 APOPTOSIS RELATED NETWORK DUE TO ALTERED NOTCH3 IN OVARIAN CANCER%WIKIPATHWAYS_20260710%WP2864%HOMO SAPIENS Apoptosis related network due to altered Notch3 in ovarian cancer RIPK2 NET1 APOE CARD14 APP HEL-S-102 JUND CTNNA1 HSPD1 PKN1 THBS1 TNF BIRC5 RPS6KB1 NQO1 HDAC1 TRAF1 TNFRSF10B NFKB1 HEL-S-89n NRG1 IL7R ERN1 GCLC ERBB3 VAV3 CDKN1A TNFRSF21 PTK2B SQSTM1 CDKN1B HELLS HEL113 SOCS3 BEX3 YBX3 AXIN1 CUL5 HEL-S-7 RNF7 MAPK1 IER3 F2R ANK2 PATHWAY IN EPILEPSY DEVELOPMENT%WIKIPATHWAYS_20260710%WP5557%HOMO SAPIENS ANK2 pathway in epilepsy development SPTBN4 SNAP25 BRSK1 ANK2 L1CAM CSNK2B KCNQ2 SCN5A SPTAN1 CSNK2A1 EIF2A SEMA3A CSNK2A2 ATF4 PRRT2 SCN2A DDIT3 CHOLESTEROL BIOSYNTHESIS WITH SKELETAL DYSPLASIAS%WIKIPATHWAYS_20260710%WP4804%HOMO SAPIENS Cholesterol biosynthesis with skeletal dysplasias LBR DHCR7 CYP51A1 DHCR24 EBP SC5D MAPK AND NFKB SIGNALING INHIBITED BY YERSINIA YOPJ%WIKIPATHWAYS_20260710%WP3849%HOMO SAPIENS MAPK and NFkB signaling inhibited by Yersinia YopJ NFKBIA MAP3K1 CHUK IKBKB MAP3K14 RRAS IKBKG NFKB1 RAF1 MAP2K6 TRAF6 MAPK1 NSP1 FROM SARS COV 2 INHIBITS TRANSLATION INITIATION IN THE HOST CELL%WIKIPATHWAYS_20260710%WP5027%HOMO SAPIENS nsp1 from SARS CoV 2 inhibits translation initiation in the host cell EIF3S3 EIF5 EIF2S3 EIF3S2 EIF3J EIF3G EIF3E EIF3F EIF3C EIF3D EIF3A EIF3B SUI1 EIF3CL EIF2S1 EIF1AX EIF2S2 HOST PATHOGEN INTERACTION OF HUMAN CORONAVIRUSES MAPK SIGNALING%WIKIPATHWAYS_20260710%WP4877%HOMO SAPIENS Host pathogen interaction of human coronaviruses MAPK signaling BCL2 MAPK10 IFITM3 IFITM1 MAPK9 MAPK3 IFITM2 RPS6KA1 IFI27 MAP3K1 EIF4E DDIT3 ATF2 MAP2K1 MAP2K2 MAPK8 BST2 RPS6KA2 JUNB MAP2K6 RAF1 MAP2K3 MAP3K10 MAP2K4 MAP3K11 JUN FOS MAPK14 MAPK12 MAPK13 MAPK11 MAPK1 ACETAMINOPHEN IN ANALGESIA AND ANTIPYRESIS%WIKIPATHWAYS_20260710%WP5444%HOMO SAPIENS Acetaminophen in analgesia and antipyresis TRPV1 HTR1A CACNA1H KCNQ2 PTGS2 PTGS1 FAAH TRPA1 KCNQ3 CORTICOTROPIN RELEASING HORMONE SIGNALING%WIKIPATHWAYS_20260710%WP2355%HOMO SAPIENS Corticotropin releasing hormone signaling NFKBIA MAPK3 JUND FOSL2 DKFZp686L0365 CRH FOSB PRKCB GNAZ PRKCA POMC CASP9 CACNA1H JUP CRHBP CASP12 CASP3 KRT1 IVL CRHR2 ARHA KRT14 TCF4 GNB2 CYP21A2 ECE1 TLR4 CAMK2A GNB3 GNB5 MAPK8 TFAP2A GNAO1 GNA11 STAR JUNB HSD3B2 MAP3K5 FOS PRKCQ MAPK14 IL2 SULT2A1 IL18 BCL2 MAPK9 GNAI1 GSK3B CYP11A1 PLCG1 PRKAA2 PRKCI NFKB1 CXCL8 ERN1 FOSL1 MAP2K1 PLCG2 CREB1 SP1 GNB1 GNAS RAF1 TGFB1 GJA1 RELA HSD3B1 ACACA TRIM28 MAPK1 GPCRS CLASS C METABOTROPIC GLUTAMATE PHEROMONE%WIKIPATHWAYS_20260710%WP501%HOMO SAPIENS GPCRs class C metabotropic glutamate pheromone GRM3 GRM2 GRM6 GABBR2 GRM8 GABBR1 CASR GPRC5A GPRC5D GPRC5C NUCLEOSOME REMODELING COMPLEX%WIKIPATHWAYS_20260710%WP5572%HOMO SAPIENS Nucleosome remodeling complex CHAF1B CHAF1A H4C9 PCNA NASP SMIM40 HIST1H4L CHEK2 HAT1 ASF1A ASF1B MCM2 PRKDC RBBP4 SUPT16H XRCC5 SSRP1 VITAMIN A AND CAROTENOID METABOLISM%WIKIPATHWAYS_20260710%WP716%HOMO SAPIENS Vitamin A and carotenoid metabolism SULT2B1 CYP2E1 NR1B3 RARA ALDH1A3 RARB ALDH1A2 SULT1A1 NPC1L1 CD36 RBP4 SCARB1 ABCG8 ABCG5 HEL-S-53e ADH1A CRABP2 RDH8 RETSAT HEL-S-4 CRABP1 RLBP1 RXRA RXRB SDR16C5 CYP26A1 RDH12 AWAT2 RDH10 LRAT BCO1 RXRG DGAT1 DHRS3 RPE65 RBP7 RBP2 RBP1 RDH5 LPL CYP26B1 MAPK1 SYNAPTIC VESICLE PATHWAY%WIKIPATHWAYS_20260710%WP2267%HOMO SAPIENS Synaptic vesicle pathway SLC17A6 SLC17A7 SLC17A8 STX2 SNAP25 SLC18A1 SLC18A2 AP2M1 SLC18A3 UNC13C SLC38A1 SYT1 CACNA1B SYP CACNA1A AP2A1 SYN2 STX1B AP2A2 UNC13B STX3A SLC25A4 VAMP2 SYN1 UNC13A STX1A CLTC SLC32A1 CLTCL1 CLTA DNM3 NAPA SLC22A3 STXBP1 CPLX2 CLN8 CPLX1 HEL-S-67p RIMS1 SLC1A3 AP2S1 HALLMARK OF CANCER SUSTAINING PROLIFERATIVE SIGNALING%WIKIPATHWAYS_20260710%WP5475%HOMO SAPIENS Hallmark of cancer sustaining proliferative signaling NFKBIA NGFR KSR1 MAPK3 GRB2 MLST8 FOXO1 LRP6 AKT1S1 MTOR JUP CSNK1A1 PML NTRK1 STAT3 CDKN1A EGFR IGF1R FLT4 NR1C2 PDGFRA JUN LRP5 FOS FGFR1 KIT MYC IL6 EPHA2 SOS2 LEF1 FGFR3 IL6R RARA WNT1 CSF1R RPTOR TSC2 SALL4 CCND1 TTI1 GSK3B AKT3 KDR GAREM2 PYGO1 RETN PTEN RUNX1T1 ZBTB16 PIK3CD INSR NFKBIE TSC1 NFKB1 HRAS ULK2 APC DEPTOR MAP2K1 MAP2K2 MDM2 NTRK2 CHUK FGFR4 IKBKB FGFR2 FLT3 IKBKG SOS1 RAF1 PIK3CA RHEB BCL9 SHC1 AXIN2 SRC TCF3 RELA FLT1 REL MAPK1 EDA SIGNALING IN HAIR FOLLICLE DEVELOPMENT%WIKIPATHWAYS_20260710%WP3930%HOMO SAPIENS EDA signaling in hair follicle development SHH BMP1 TNLG7C PTCH1 DKK1 DKK4 EDARADD LTB RELB SOSTDC1 EDAR WNT3 TYROBP CAUSAL NETWORK IN MICROGLIA%WIKIPATHWAYS_20260710%WP3945%HOMO SAPIENS TYROBP causal network in microglia SH2B3 RGS1 GAL3ST4 SLC7A7 NCF2 GPX1 HCLS1 NPC2 TYROBP DPYD IL18 opn RUNX3 TGFBR1 IL13RA1 ITGAM RPS6KA1 CREB3L2 ITGAX TNFRSF1B C1QC CD84 NRROS CXCL16 FKBP15 PLEK LOXL3 GIMAP2 TCIRG1 MAF PPP1R18 PYCARD LYL1 CD37 RNASE6 HEL-S-66 IL10RA LGALS9C APBB1IP BIN2 ELF4 SFT2D2 RBM47 IGSF6 KCNE3 SAMSN1 ZFP36L2 HEL-S-62p HLX CENTA2 CYTL1 NCKAP1L LHFPL2 GAPT LIPID METABOLISM PATHWAY%WIKIPATHWAYS_20260710%WP3965%HOMO SAPIENS Lipid metabolism pathway PRKAB2 LIPE PNPLA2 PRKAB1 ABHD5 PRKAR1B ACSS2 PRKAR1A AKT3 PRKAA1 PRKAA2 ACLY PRKACG HILPDA PRKAG1 ACACA FASN PLIN1 PRKAG2 PDHA1 PRKAG3 CHOLESTEROL BIOSYNTHESIS PATHWAY%WIKIPATHWAYS_20260710%WP197%HOMO SAPIENS Cholesterol biosynthesis pathway MVD FDFT1 DHCR7 FDPS HMGCS1 CYP51A1 HMGCR MVK MSMO1 SQLE PMVK SC5D OCTADECANOID FORMATION FROM LINOLEIC ACID%WIKIPATHWAYS_20260710%WP5324%HOMO SAPIENS Octadecanoid formation from linoleic acid ALOX15 CYP1A2 CYP4A11 EPHX3 CYP3A4 PTGS2 ALOX12B CYP2C9 CYP2C19 ALOXE3 PTGS1 GPX4 DOPAMINE METABOLISM%WIKIPATHWAYS_20260710%WP2436%HOMO SAPIENS Dopamine metabolism HEL-S-44 NQO1 TH PRKACG PPP2CA DDC MAOA TYR FELBAMATE METABOLISM%WIKIPATHWAYS_20260710%WP2816%HOMO SAPIENS Felbamate metabolism CYP2E1 CYP3A4 HALLMARK OF CANCER NON MUTATIONAL EPIGENETIC REPROGRAMMING%WIKIPATHWAYS_20260710%WP5483%HOMO SAPIENS Hallmark of cancer non mutational epigenetic reprogramming IRS1 CREBBP PIP4K2A IFITM3 HDAC2 EP300 HDAC1 EZH2 ANKRD13C CADM1 TET2 NOL9 CANCER IMMUNOTHERAPY BY PD 1 BLOCKADE%WIKIPATHWAYS_20260710%WP4585%HOMO SAPIENS Cancer immunotherapy by PD 1 blockade NFAT5 PDCD1LG2 HLA-A NFATC4 BATF PDCD1 CD8B CD8A HLA-DRB1 ZAP70 NFATC2 LCK CD3G JUN CD3E NFKB1 NFATC1 CD3D IFNG NFATC3 STAT3 PTPN11 AIRWAY SMOOTH MUSCLE CELL CONTRACTION%WIKIPATHWAYS_20260710%WP4962%HOMO SAPIENS Airway smooth muscle cell contraction PPP1R14A IL13 GDI1 RYR1 MYLK ROCK1 HEL-S-80p ARHA ROCK2 PLCB1 MYL1 ADRB2 CALM1 ARTEMISININ INHIBITION OF UVEAL MELANOMA%WIKIPATHWAYS_20260710%WP5441%HOMO SAPIENS Artemisinin inhibition of uveal melanoma MTOR AKT3 VALPROIC ACID PATHWAY%WIKIPATHWAYS_20260710%WP3871%HOMO SAPIENS Valproic acid pathway CYP2B6 ABAT IVD HDAC1 HSD17B10 ACADSB HADHB CYP2C9 CYP2A6 EHHADH COMPLEMENT ACTIVATION%WIKIPATHWAYS_20260710%WP545%HOMO SAPIENS Complement activation MASP2 MASP1 CFD C4A C1QB C6 C1QA C7 C1S C9 CD55 C4B_2 CFB HEL-S-62p C8A CFP C1QC C8G TAMOXIFEN METABOLISM%WIKIPATHWAYS_20260710%WP691%HOMO SAPIENS Tamoxifen metabolism CYP2E1 UGT2B7 CYP3A4 UGT1A8 CYP2C19 CYP2C9 SULT1E1 SULT1A1 UGT1A10 UGT1A4 CYP1A2 CYP1A1 CYP1B1 SULT2A1 CYP2A6 UGT2B15 EFFECT OF OMEGA 3 PUFA ON HUNTINGTON 39 S DISEASE PATHWAYS%WIKIPATHWAYS_20260710%WP5470%HOMO SAPIENS Effect of omega 3 PUFA on Huntington 39 s disease pathways MAPK10 MLST8 BNIP3 AKT1S1 EIF4E RPS6KA5 RICTOR CYP46A1 HTT GABRA3 EGF RPTOR PRKAA1 HAP1 PRKAA2 PTEN PRKAG1 PIK3CD PIK3R3 TSC1 PRKAG2 PIK3R1 PRKAG3 EIF4EBP1 SLC12A2 CREB1 NTRK2 PRKAB2 HMGCS1 BDNF PRKAB1 NR1H2 RAF1 SREBF2 MAP3K10 PIK3CA RHEB DHCR7 ABCG1 GABRG3 GABRG1 SIN3A MAPK1 APOE MAPK3 ABCA1 GABRB3 GABRB2 GABRB1 KIF5A ABCG4 NEUROD1 PI3 AHI-1 HEL-S-29 MTOR REST RAB3GAP1 CASP8 CASP3 HDAC2 RPS6KB1 HDAC1 EGFR MAPK8 BCL2L11 GABRE GABRQ GABRA2 GABRP SLC12A5 GABRA6 MAP2K4 GABRA5 GABRA4 PIK3C2G PIK3C2B CYP51A1 IL6 BCL2 BAX PIK3R4 BCL2L1 PIK3R5 MAPK9 PPARGC1A C1QA TSC2 AKT3 BAD IL1B NFKB1 HRAS DEPTOR MAP2K1 MAP2K2 IKBKB SP1 HMGCR OPA1 PIK3R2 MBP SOX GENES AND THEIR INFLUENCE ON NEUROGENESIS AND NEURODEVELOPMENTAL DISORDERS%WIKIPATHWAYS_20260710%WP5568%HOMO SAPIENS SOX genes and their influence on neurogenesis and neurodevelopmental disorders SOX4 H4C9 HIST1H4L TEAD2 YES1 SRRT SOX11 SOX12 POU3F1 POU3F2 SOX2 UTF1 SOX15 ZSCAN10 FGF4 WWTR1 SHANK3 PATHWAY INVOLVED IN PHELAN MCDERMID SYNDROME%WIKIPATHWAYS_20260710%WP5566%HOMO SAPIENS SHANK3 pathway involved in Phelan McDermid syndrome PS1TP5BP1 SPTAN1 SPAAR CTNND2 HRAS ARHGAP44 SHARPIN CAMK2A DLGAP1 SYNGAP1 LZTS3 BAIAP2 ADGRL1 HCN1 HOMER1 GRIN2B GRIN1 ARHGEF7 DLG4 SHANK3 ITGB1 RAP1A PAK1 MAP3K7 GRIA2 CDC42 TRYPTOPHAN KYNURENINE PATHWAY IN POST COVID SYNDROME%WIKIPATHWAYS_20260710%WP5549%HOMO SAPIENS Tryptophan kynurenine pathway in post COVID syndrome AADAT IFNB1 DDC GOT2 TNF HAAO TDO2 KYNU AFMID KMO KYAT3 KYAT1 IDO2 IFNA6 IDO1 IL1B AHR IL6 IFNG OXYTOCIN SIGNALING%WIKIPATHWAYS_20260710%WP2889%HOMO SAPIENS Oxytocin signaling OXTR VITAMIN B12 METABOLISM%WIKIPATHWAYS_20260710%WP1533%HOMO SAPIENS Vitamin B12 metabolism HEL-S-44 APOE APOB ABCA1 FGA TNF CTH SAA1 SAA2 CRP IL1B INSR NFKB1 INS NFKB2 SCARB1 CCL2 F7 HEL-S-78p SAA4 PLAT MPO MCEE CUBN PLG HBA2 TCN1 F2 LDLR MTRR HBB CBLIF MTR MAT1A HEL-S-51e RELA CBS TCN2 IL6 ALB IFNG CCL5 THYROID HORMONES PRODUCTION AND PERIPHERAL DOWNSTREAM SIGNALING EFFECTS%WIKIPATHWAYS_20260710%WP4746%HOMO SAPIENS Thyroid hormones production and peripheral downstream signaling effects GRB2 MLST8 FOXO1 ITPR2 AKT1S1 POMC MTOR CASP9 RPS6KB1 NPPB ATF2 ADRB3 MAPKAPK3 MC4R NPY AgRP KDM1A AQP7 ADCY3 TRH TTF2 TTF1 NOTCH1 ADCY8 NHSL1 DUOXA2 TSHB SECISBP2L DIO1 SIRT6 FRS2 PAX8 MAPK14 FGFR1 ZNF516 MGLL KDM3B SLC5A5 DUOX2 DEHAL1 SLC16A10 MAFA TSHR TG SLC26A4 SHH ITGB3 ACTL6B PPARGC1A WNT4 RPTOR TSC2 CREB3 GSK3B AKT3 BAD RPS6 ITGAV TSC1 PRDM16 UCP1 HRAS MAP2K1 PPARG MDM2 FGF21 RPS6KA6 PNPLA2 TBC1D4 RXRA SLC16A2 SOS1 RAF1 PIK3CA TPO RHEB THRA PFKFB2 SRC PLIN1 SLCO1C1 NR1A2 MAPK1 METABOLIC PATHWAYS OF FIBROBLASTS%WIKIPATHWAYS_20260710%WP5312%HOMO SAPIENS Metabolic pathways of fibroblasts P3H4 PSPH PLOD1 BMP1 HEL-S-133P P3H3 UGDH FGFR4 LPAR1 ADAMTS2 P4HA1 P4HA2 P4HA3 ALDH18A1 GLUD1 PSAT1 GCK CD36 PLCG1 FGFR1 ARHA PHGDH GLS LOXL2 BREAST CANCER PATHWAY%WIKIPATHWAYS_20260710%WP4262%HOMO SAPIENS Breast cancer pathway GRB2 CSNK2B LRP6 FZD1 CSNK1A1 FZD7 FZD8 SFRP4 FZD2 BRCA1 JAG2 IGF1R FLT4 DLL3 FGFR1 KIT FGF8 POLK RAD50 RAD51 EGF MRE11A CCND1 NBN GSK3B BRCA2 FZD9 FGF16 PTEN PIK3CD FZD10 PIK3R3 NOTCH3 NOTCH4 DLL4 PIK3R1 NRAS FGF19 FGF21 SHC2 RAF1 PIK3CA SHC4 MAPK1 RPS6KB2 MAPK3 FGF3 FGF6 FGF9 SKP1 MTOR FGF20 RPS6KB1 FGF22 FGF17 FGF23 FGF18 RB1 CDKN1A EGFR GADD45B FGF7 TNFSF11 GADD45G BAK1 ATR FZD5 NOTCH1 WNT2B JUN LRP5 FOS FRAT1 MYC E2F2 E2F3 WNT5B FGF4 AXIN1 DDB2 IGF1 WNT16 SOS2 LEF1 BAX FGF10 NCOA1 ERBB2 DVL1 DVL2 DVL3 FRAT2 NR3A2 WNT1 PGR WNT3 ARAF WNT4 CETN3 WNT10B APC2 TCF7L2 CSNK1A1L WNT10A TCF7L1 AKT3 GADD45A WNT3A WNT7B WNT7A FGF2 NFKB2 HRAS APC MAP2K1 MAP2K2 ATM CDK6 CDK4 SP1 HEY2 SOS1 CSNK2A1 CSNK2A3 CSNK2A2 SHC3 SHC1 AXIN2 PIK3R2 NOTCH2 HES1 HES5 FZD3 PROLINE AND HYDROXYPROLINE PATHWAYS%WIKIPATHWAYS_20260710%WP5026%HOMO SAPIENS Proline and hydroxyproline pathways PRODH OLIGODENDROCYTE SPECIFICATION AND DIFFERENTIATION LEADING TO MYELIN COMPONENTS FOR CNS%WIKIPATHWAYS_20260710%WP4304%HOMO SAPIENS Oligodendrocyte specification and differentiation leading to myelin components for CNS SHH BMP4 CXCL2 BMP2 TNF CNP SOX8 LIF NKX2-2 NKX2-6 MOG IL1B FGF2 CXCL1 OMG MYT1 SOX9 SOX6 SOX5 OLIG1 CNTF OLIG2 ASCL1 SOX10 MBP IGF1 ENERGY METABOLISM%WIKIPATHWAYS_20260710%WP1541%HOMO SAPIENS Energy metabolism MEF2D NCOA1 FOXO1 MEF2C UCP2 PPARGC1A GSK3B PRKAA1 EP300 PRKAA2 NRF1 HDAC1 TFB1M PPP3CA PRKAG1 UCP3 CAMK4 ESRRA PPP3R1 MED1 PRKAG2 PPP3R2 MEF2B MYBBP1A PRMT1 TFB2M PPRC1 PRKAG3 SIRT1 SIRT3 ATF2 PPP3CC TFAM PPARG PPARGC1B CREB1 CAMK2G PRKAB2 PRKAB1 RXRA NR1C2 GABPA MAPK14 FOXO3A NR1C1 STEROIDOGENIC PATHWAY%WIKIPATHWAYS_20260710%WP4463%HOMO SAPIENS Steroidogenic pathway CYP11A1 HSD17B1 HSD3B1 STAR CYP17A1 SRF AND MIRS IN SMOOTH MUSCLE DIFFERENTIATION AND PROLIFERATION%WIKIPATHWAYS_20260710%WP1991%HOMO SAPIENS SRF and miRs in smooth muscle differentiation and proliferation MYOCD NKX2-5 KLF4 MEF2D MEF2C CCND2 MEF2B CAMK2D IL1 SIGNALING%WIKIPATHWAYS_20260710%WP195%HOMO SAPIENS IL1 signaling NFKBIA MAPK9 MAPK3 IL1R1 MAP3K1 PLCG1 HEL-S-71 IL1B IRAK2 NFKB1 TAB3 PIK3R1 PRKCZ ATF2 MAP2K1 MAP2K2 HSPB2 MAPK8 ECSIT CHUK IRAK3 IRAK4 MAP3K7IP1 IKBKB IL1A MAPKAPK2 MAP3K14 PELI1 IKBKG MAP2K6 MAP2K3 MAP2K4 IRAK1 SQSTM1 JUN PIK3R2 MAPK14 NFKBIB RELA MAP3K7 REL MAP3K2 TRAF6 MYD88 MAPK1 PTPN11 UBE2V1 SYNTHESIS OF CERAMIDES AND 1 DEOXYCERAMIDES%WIKIPATHWAYS_20260710%WP5194%HOMO SAPIENS Synthesis of ceramides and 1 deoxyceramides SPTLC1 CERS3 CERS5 SPHK1 CERS6 CERK SGMS1 LASS1 UGT8 A4GALT SGMS2 UGCG DGAT1 KDSR DES CERS2 B4GALNT1 B4GALT1 A3GALT2 B3GNT5 NAD BIOSYNTHESIS II FROM TRYPTOPHAN%WIKIPATHWAYS_20260710%WP2485%HOMO SAPIENS NAD biosynthesis II from tryptophan KMO HEL-S-90n NMNAT1 HAAO TDO2 NADSYN1 KYNU AFMID CANONICAL NF KB PATHWAY%WIKIPATHWAYS_20260710%WP4562%HOMO SAPIENS Canonical NF kB pathway NFKBIA CHUK IKBKB RELA NFKBIE IKBKG NFKB1 REL SPHINGOLIPID PATHWAY%WIKIPATHWAYS_20260710%WP1422%HOMO SAPIENS Sphingolipid pathway SPTLC1 CERS3 SPHK2 CERS5 SPHK1 CERS6 CERK SGMS1 PPP2CA UGT8 SGMS2 ASAH2 UGCG SGPP2 GBA2 ACER1 KDSR SGPL1 SPTLC2 CERS2 SPTLC3 SERINC1 CERT1 PLPP1 MIR 509 3P ALTERATION OF YAP1 ECM AXIS%WIKIPATHWAYS_20260710%WP3967%HOMO SAPIENS miR 509 3p alteration of YAP1 ECM axis TWIST1 COL1A1 SNAI2 EDNRA TEAD2 TEAD3 TEAD4 PBX3 SPARC THBS2 COL3A1 GPC6 YAP1 ALSTROM SYNDROME%WIKIPATHWAYS_20260710%WP5202%HOMO SAPIENS Alstrom syndrome IFT74 SNAPIN RFX2 IFT25 DTNBP1 RFX3 RABL2B IFT172 RFX1 TUBG1 RILPL1 MYO5B SMO ALMS1 STX5A CEP192 IFT81 VCP DNM3 PTCH1 TFDP2 GPR161 CEP19 BLOC1S4 VCPIP1 E2F4 BLOC1S6 BLOC1S1 IFT27 CIMAP3 ACTN4 ELECTRON TRANSPORT CHAIN OXPHOS SYSTEM IN MITOCHONDRIA%WIKIPATHWAYS_20260710%WP111%HOMO SAPIENS Electron transport chain OXPHOS system in mitochondria UCP2 NDUFA5 NDUFA13 NDUFA11 NDUFA12 NDUFA10 ATP5G1 COX6A2 HEL-S-271 ATP5IF1 NDUFC2 NDUFC1 SDHC SDHD COX7A2L NDUFS6 NDUFS5 COX7B NDUFS4 NDUFS1 ND3 ND2 SLC25A14 ND5 SLC25A6 ND4 COX6A1 NDUFB9 COX7C ND6 NDUFB8 NDUFB7 NDUFB6 ATP8 NDUFB5 NDUFB4 NDUFB3 COX8A SLC25A5 ATP6 COX17 SDHB ND1 ATP5MC2 NDUFB2 COX11 SDHA ATP5J NDUFB1 ATP5MC3 COX7A2 ATP5H HEL-S-123m SLC25A27 COX6B1 NDUFV3 SCO1 NDUFV2 ATP5MG ATP5MF ATP5ME DMAC2L SURF1 NDUFA7 NDUFA6 ZNF183 ATP5PB NDUFA3 NDUFA2 ND4L ATP5F1D ATP5F1E NDUFAB1 ATP5PO CYB COX5A COX7A1 UQCRFS1 SLC25A4 NDUFS8 UQCRC1 COX3 NDUFS3 COX2 COXFA4 COX1 UQCRC2 UQCRB UQCR11 UCP3 UQCR10 UQCRH UCP1 NDUFA9 UQCRQ NDUFB10 G PROTEIN SIGNALING%WIKIPATHWAYS_20260710%WP35%HOMO SAPIENS G protein signaling PRKCB GNAZ PRKCA GNA15 PLCB3 ADCY9 PPP3CA PRKACG ARHA RRAS PRKD1 GNB2 CALM1 GNB3 GNB5 GNAO1 GNA11 KCNJ3 ADCY3 ADCY1 ADCY8 PRKCE ADCY6 GNG3 PRKAR1B ADCY5 GNG5 PRKD3 GNG4 PRKAR1A PRKCQ GNA13 GNG7 GNG8 ARHGEF1 GNAL GNAI3 HEL159 AKAP12 AKAP10 AKAP11 PDE4B PDE4A PDE4D GNAI1 AKAP9 PDE1C PDE1B AKAP8 AKAP7 AKAP6 AKAP5 AKAP4 GNA14 PDE7B PDE7A PRKCI PRKCH HRAS PRKCZ PDE1A PPP3CC NRAS GNGT1 GNB1 PDE8A GNAS GNG10 GNG12 GNG11 GNG13 GNGT2 GLYCOSPHINGOLIPID METABOLISM%WIKIPATHWAYS_20260710%WP5292%HOMO SAPIENS Glycosphingolipid metabolism GLA UGT8 A4GALT UGCG GBA2 B3GALT1 ST3GAL5 B4GALNT1 A3GALT2 B4GALT4 NEU3 B4GALT5 NEU4 B3GALT2 B3GNT5 EFFECTS OF NITRIC OXIDE%WIKIPATHWAYS_20260710%WP1995%HOMO SAPIENS Effects of nitric oxide NOS2 COX1 AOX1 HBA2 XDH HBB FERROPTOSIS%WIKIPATHWAYS_20260710%WP4313%HOMO SAPIENS Ferroptosis ALOX15 HMOX1 ACSL1 FACL4 ACSL3 GPX4 SLC11A2 GCLC GCLM DKFZp686F0183 TF PRNP NOX4 AKR1C1 AKR1C2 CBS HEL-S-64p CYBB HEL-S-102 CP SLC38A1 FTL ACSL6 CTH ACSL5 MAP1LC3A STEAP3 TFRC IREB2 SLC40A1 CISD1 SAT2 BACH1 MAP1LC3C AIFM2 FTH1 SLC39A8 FDFT1 SLC39A14 POR VDAC3 CHMP6 CHMP5 HMGCR SLC3A2 DKFZp762B153 DPP4 FTMT PCBP1 PHKG2 COQ2 LPCAT3 SLC7A11 SPINAL CORD INJURY%WIKIPATHWAYS_20260710%WP2431%HOMO SAPIENS Spinal cord injury NGFR GFAP ACAN CXCL2 PTGS2 PRKCA PPP3CA ARHA TLR4 ARG1 PLA2G2A TNLG7A SLIT2 NOX4 GDNF NTN1 TNF AQP1 CCND1 CHST11 FKBP1A RAC1 COL4A1 NOS2 BDNF GRIN1 LTB XYLT1 AQP4 ZFP36 GJA1 SEMA6A PDYN BCAN KLK8 PLA2G5 TNFSF13 CSPG4 BTG2 PLA2G6 NCAN PRB1 PRB2 PLXNA2 ANXA1 TACR1 RGMA COL2A1 MMP12 MMP9 VCAN MAPK1 GAP43 CD47 AIF1 SLIT1 CDK2 SLIT3 MAPK3 LILRB3 FCGR2A APEX1 CCNG1 CASP3 ROS1 EGR1 RB1 EGFR CDC2 IL1A EPHA4 CDKN1B FOS EFNB2 IL2 MYC FOXO3A IL6 IFNG E2F5 LTB4R LEP C1QB IL1R1 GADD45A CCR2 IL1B CXCL8 CXCL1 CCL2 OMG CDK4 RTN4R SOX9 RTN4 IL4 TGFB1 HEL113 RHOB ROCK2 SELP MBP CDC42 TARGETING YAP IN PANCREATIC DUCTAL ADENOCARCINOMA PDAC %WIKIPATHWAYS_20260710%WP5495%HOMO SAPIENS Targeting YAP in pancreatic ductal adenocarcinoma PDAC PRKAB2 HMGCR MOB1A PRKAB1 RHOD CYR61 TEAD2 TEAD3 TEAD4 LATS1 LATS2 RHOB PRKAA1 PRKAA2 STK4 ARHA RHO PRKAG1 PRKAG2 CTGF YAP1 PRKAG3 NON SMALL CELL LUNG CANCER%WIKIPATHWAYS_20260710%WP4255%HOMO SAPIENS Non small cell lung cancer MAPK3 GRB2 KIF5A PRKCB EML4 FHIT PRKCA CASP9 CASP8 CASP3 CYCS RB1 STAT3 CDKN1A EGFR GADD45B CRABP2 GADD45G CRABP1 BAK1 RXRB RXRG CDKN2A HEL-S-61 RET FOXO3A E2F2 ALK E2F3 JAK3 DDB2 STAT5B SOS2 POLK BAX ERBB2 RARB ARAF EGF CCND1 AKT3 PLCG1 GADD45A BAD PIK3CD HRAS MAP2K1 NRAS PLCG2 MAP2K2 PDPK1 CDK6 CDK4 RXRA SOS1 RAF1 RASSF1 PIK3CA TGFA STK4 HGF MAPK1 LACTATE SHUTTLE IN GLIAL CELLS%WIKIPATHWAYS_20260710%WP5314%HOMO SAPIENS Lactate shuttle in glial cells NUDT14 SLC4A4 HEL-S-133P HEL-S-281 SLC2A3 SLC16A3 HEL-76 CA4 SLC1A2 SLC16A7 GNAQ PATHWAYS IN PORT WINE STAIN%WIKIPATHWAYS_20260710%WP5437%HOMO SAPIENS GNAQ pathways in port wine stain MAP2K2 TRIO MAPK3 RAF1 MAP2K6 MAP2K3 PIK3CA MAP2K4 MTOR AMOT RAC1 ARHA NFKB1 MAP2K5 YAP1 MAP2K1 MAPK1 LEPTIN INSULIN SIGNALING OVERLAP%WIKIPATHWAYS_20260710%WP3935%HOMO SAPIENS Leptin insulin signaling overlap IRS4 PDPK1 LEPR LEP IRS1 SOCS2 INSR PIK3R3 SOCS3 SOCS1 INS DGKZ STAT3 AMINO ACID METABOLISM PATHWAY EXCERPT HISTIDINE CATABOLISM EXTENSION%WIKIPATHWAYS_20260710%WP4661%HOMO SAPIENS Amino acid metabolism pathway excerpt histidine catabolism extension HAL UROC1 FTCD GPT2 GLUD1 METABOLISM OF SPHINGOLIPIDS IN ER AND GOLGI APPARATUS%WIKIPATHWAYS_20260710%WP4142%HOMO SAPIENS Metabolism of sphingolipids in ER and Golgi apparatus CERS3 SPHK2 SPHK1 CERK SGMS1 UGT8 SGMS2 SGPP1 UGCG SGPP2 B3GALT1 KDSR SGPL1 B4GALT2 B4GALNT1 B4GALT1 GALNT16 GALNT1 B3GALT2 CONGENITAL GENERALIZED LIPODYSTROPHY%WIKIPATHWAYS_20260710%WP5101%HOMO SAPIENS Congenital generalized lipodystrophy GRB2 LPIN1 FYN ITGB4 HMFN0839 PIK3CA IRS1 DGAT1 DGAT2 HIF1A CAVIN1 LPIN2 BSCL2 INS LPIN3 4P16 3 COPY NUMBER VARIATION%WIKIPATHWAYS_20260710%WP5365%HOMO SAPIENS 4p16 3 copy number variation FGFR3 MAPK3 GRB2 PLCG1 FGF2 SLBP PIK3R1 UBE2J2 ERI1 NSD2 TMEM129 FAM53A NAT8L NELFCD NELFA NELFE POLN H3F3B CKAP5 LETM1 NELFB NICOL1 CLTCL1 TACC3 SOS1 FRS2 CBL MAPK1 IL9 SIGNALING%WIKIPATHWAYS_20260710%WP22%HOMO SAPIENS IL9 signaling MAP2K2 CDK9 GRB2 MAPK3 IL9R STAT1 PIK3R2 IL2RG JAK1 JAK3 PIK3R1 IL9 STAT5B MAP2K1 STAT3 MAPK1 ARACHIDONATE EPOXYGENASE EPOXIDE HYDROLASE%WIKIPATHWAYS_20260710%WP678%HOMO SAPIENS Arachidonate epoxygenase epoxide hydrolase EPHX2 HEL-S-22 CYP2J2 COX8A CYP2C9 COX5A H19 RB E2F1 AND CDK BETA CATENIN IN COLORECTAL CANCER%WIKIPATHWAYS_20260710%WP3969%HOMO SAPIENS H19 Rb E2F1 and CDK beta catenin in colorectal cancer SOX4 CCND1 CDK4 CDK8 MED1 PMAIP1 CSRP2 RB1 ESTROGEN SYNTHESIS AND METABOLISM%WIKIPATHWAYS_20260710%WP5276%HOMO SAPIENS Estrogen synthesis and metabolism UGT2A2 UGT2B7 HSD17B10 CYP3A4 UGT1A8 HSD17B8 CYP2C19 CYP2C9 CYP3A7 SULT1E1 UGT1A10 HSD17B3 CYP1A2 HSD17B4 HSD17B1 HSD17B2 CYP1B1 HSD17B7 DISORDERS OF NAD METABOLISM%WIKIPATHWAYS_20260710%WP5506%HOMO SAPIENS Disorders of NAD metabolism BST1 NAXE NAXD NADSYN1 CYSTEINE AND METHIONINE CATABOLISM%WIKIPATHWAYS_20260710%WP4504%HOMO SAPIENS Cysteine and methionine catabolism SQOR MTR MAT1A SUOX CBS ETHE1 HEL-S-64p GCLC pcap CTH CDO1 HEL-S-61p EXTRAFOLLICULAR AND FOLLICULAR B CELL ACTIVATION BY SARS COV 2%WIKIPATHWAYS_20260710%WP5218%HOMO SAPIENS Extrafollicular and follicular B cell activation by SARS CoV 2 PTPRC SH2D1A PDCD1 IFITM1 FOXO1 C4A CD40 CRP SELL IFNAR2 TLR4 CXCR5 TLR7 TNLG7A CCL19 CD82 SYK BACH2 AID TMSB10 FCRL5 MFGE8 PAX5 BCR EBI3 BASH IL2 CD1D CD79A TBX21 HEL-S-72p BTLA SLAMF7 IL6 GPR183 IFNG CD69 IFIT2 CD22 IRF4 ZEB2 IRF8 CXCR4 CCL21 MS4A1 TNF CD40LG CCR7 CR2 ITGAX XBP1 CXCL13 IL-21 BCL6 ISG15 MAF ICOS CXCL12 IL10 IL4 CD80 IL12A HEL-S-62p CD19 TNFSF13 CR1 IRINOTECAN PATHWAY%WIKIPATHWAYS_20260710%WP229%HOMO SAPIENS Irinotecan pathway UGT1A9 CES2 ABCG2 SLCO1B1 CYP3A4 CES1 ABCC1 UGT1A10 BCHE ABCC2 UGT1A1 MAMMARY GLAND DEVELOPMENT INVOLUTION STAGE 4 OF 4%WIKIPATHWAYS_20260710%WP2815%HOMO SAPIENS Mammary gland development involution stage 4 of 4 CHI3L1 BAX IL6ST SOCS3 MYC STAT3 MMP9 SMALL LIGAND GPCRS%WIKIPATHWAYS_20260710%WP247%HOMO SAPIENS Small ligand GPCRs CNR2 MTNR1A CNR1 MTNR1B S1PR1 PTGER4 LPAR1 S1PR3 S1PR2 S1PR4 PTGER1 PTGER2 PTGER3 PTGIR PTGDR PTGFR GPR50 TBXA2R 10Q22Q23 COPY NUMBER VARIATION%WIKIPATHWAYS_20260710%WP5402%HOMO SAPIENS 10q22q23 copy number variation VEGFA SMC3 PDS5B PDS5A WAPAL RAD21 TNFSF11 ERBB4 STAG1 GLUD1 ADAM10 CEBPA MAS1 MAD2L2 SH2D4B FAM25A BUB1B ADIRF LDB3 BMP2 GHITM IQUB ROPN1L RSPH6A BMPR1A SIRT4 DNAJB13 NME5 NRG3 CDHR1 MMRN2 DYDC2 DYDC1 RGR RSPH9 GPR15LG SNCG SUSD2 RSPH3 TSPAN14 RSPH1 NFKB1 LRIT2 SH3GL3 SHLD3 SMC1A LRIT1 PRXL2A SHLD2 PPARG SHLD1 OPN4 RSPH14 CCSER2 ZMYND11 MAT1A ACTN2 ATR SIGNALING%WIKIPATHWAYS_20260710%WP3875%HOMO SAPIENS ATR signaling RPA1 HUS1 RAD1 RPA3 TOPBP1 RAD9B ATRIP RAD9A ATR CHEK1 11P11 2 COPY NUMBER VARIATION SYNDROME %WIKIPATHWAYS_20260710%WP5348%HOMO SAPIENS 11p11 2 copy number variation syndrome LGALS3BP SDCBP SHH LEF1 TIMP1 HBEGF MS4A1 CD151 CHST6 REST B4GALT4 CHST1 ITGA4 CRY2 CD63 IGSF8 SPPL2C NRXN1 ITGA6 PRDM11 ACCS PHF21A CD82 ALKBH3 C11orf96 ALX4 TP53I11 EXT1 CD19 LARGE2 EXT2 ITGB1 PEX16 IZUMO1 HLA-DMA SLC35C1 HLA-DMB SYT13 MAPK8IP1 VANGL1 FREY1 SLC25A17 GLI3 B4GAT1 B3GNT7 PEX3 TSPAN18 FATTY ACID AND LIPOPROTEIN TRANSPORT IN HEPATOCYTES%WIKIPATHWAYS_20260710%WP5323%HOMO SAPIENS Fatty acid and lipoprotein transport in hepatocytes PCSK9 STARD3 SORT1 APOE SLC27A3 APOB LPA SLC27A2 ABCA1 ACSL1 ACSL3 HEL-S-104 ACSL6 ACSL5 FABP1 FABP2 DBI SLC27A4 LIPA SCARB1 NPC2 APOC1 MYLIP STAR LDLR SOAT1 SOAT2 APOA4 APOC2 SLC27A1 HEMATOPOIETIC STEM CELL DIFFERENTIATION%WIKIPATHWAYS_20260710%WP2849%HOMO SAPIENS Hematopoietic stem cell differentiation ARHH TRAF3IP3 IKZF1 HMGN5 TRIM29 HES6 FOSB CBFA2T3 RUNX1 ZNF835 NFATC2 ABO MUC1 MXI1 NFE2 RIOK3 KLF1 FLI1 GP9 CSF1 IL1A LMO2 GATA1 CSF2 NOTCH1 VAV1 FOS GATA2 CD34 CSF3 IL6 SPI1 EPO LEF1 MHC2TA IL3 ITGB3 CXCR4 ITGA2B XB IL1B MYB KITLG LYL1 TPO ACVR1B IL5 NCKAP1L NR1A2 PIM1 DNA IR DOUBLE STRAND BREAKS AND CELLULAR RESPONSE VIA ATM%WIKIPATHWAYS_20260710%WP3959%HOMO SAPIENS DNA IR double strand breaks and cellular response via ATM BAX SMC3 ACTL6A RAD52 CHEK2 RAD50 CHEK1 RAD51 CDK5 CASP9 MRE11A NBN BRCA2 CASP3 APAF1 MDC1 RIF1 KAT5 HSF1 PRKDC TP53BP1 RAD17 MCPH1 SMC1A ATF2 BRCA1 FANCD2 MDM2 ATM PCNA TP73 BAK1 BLM ATR TERF2 RASSF1 LATS1 CDKN2A H2AX NABP2 RAD9A RNF8 YAP1 TRIM28 TRAF6 NICOTINE EFFECT ON DOPAMINERGIC NEURONS%WIKIPATHWAYS_20260710%WP1602%HOMO SAPIENS Nicotine effect on dopaminergic neurons KCNK3 SLC18A2 GNB1 DDC GNAI1 CDK5 GNG2 TH DRD2 CHRNB2 CHRNA3 DRD3 KCNK9 DRD4 CHRNA5 CHRNA6 PPP1R1B 13Q12 12 COPY NUMBER VARIATION%WIKIPATHWAYS_20260710%WP5406%HOMO SAPIENS 13q12 12 copy number variation MAPK9 DMD RAC1 TRAF1 ARHA TRAF3 MIPEP C1QTNF9 MAPK8 TNFRSF19 ATXN1 SACS RTN4R SNTA1 LINGO1 C1QTNF9B SPATA13 RTN4 SSPN SNTB1 SGCD SGCA TRAF2 SGCB SGCG DAG1 CDC42 TRAF5 MARKERS OF KIDNEY CELL LINEAGE%WIKIPATHWAYS_20260710%WP5236%HOMO SAPIENS Markers of kidney cell lineage PAX2 LHX1 PECAM1 ALDH1A2 NPHS1 NPHS2 DES WT1 DKFZp781O1323 FGF7 REN CITED1 TCF21 RSPO3 NOTCH1 RSPO1 DACT1 EMX2 PBX1 FOXD1 OSR1 KCTD1 SFRP1 TSHZ3 KIT EGLN3 TBX18 SIX1 TLX1 SMAD1 FAT4 VSX2 FGF8 EPO SALL1 HNF4A SIX2 NT5E EYA1 BMP4 DCN EGLN1 GDNF NTN1 WNT4 EGLN2 TNC KDR HNF1A BMP7 AXIN2 ACTA2 TCF2 NOTCH2 WNT BETA CATENIN SIGNALING IN LEUKEMIA%WIKIPATHWAYS_20260710%WP3658%HOMO SAPIENS Wnt beta catenin signaling in leukemia LEF1 DKK1 FLT3 RARA WNT1 LRP6 NR1C2 BCL9 LRP5 JUP CSNK1A1 AXIN2 SALL4 TCF3 CCND1 GSK3B PYGO1 RUNX1T1 ZBTB16 PML MYC WIF1 APC ALZHEIMER 39 S DISEASE%WIKIPATHWAYS_20260710%WP5124%HOMO SAPIENS Alzheimer 39 s disease TUBA3E TUBA1C TUBB6 AGER TUBA1B TUBA1A TUBB1 LRP6 TUBB ATF4 FZD1 CSNK1A1 TUBB4B TUBB4A FZD7 TUBA4A TUBB2A FZD8 PPP3CA SFRP4 TUBA2 FZD2 TUBA8 SLC25A6 NOX4 ADAM10 PSENEN BACE1 APP PSEN2 PSEN1 FZD9 XBP1 FZD10 SNCA EIF2S1 INS ERN1 DDIT3 CHRNA7 IRS4 NOS2 VDAC3 EIF2AK2 RYR3 LPL PSMD7 ITPR2 CASP9 CASP8 CASP3 CYCS FADD CSF1 PSMD12 PSMD13 RB1CC1 DKK1 LRP5 AMBRA1 ATG101 ADAM17 WIPI1 ARAF GPR83 AKT3 PSMD2 HRAS PPP3CC MAP2K1 MAP2K2 RTN4 hCG_2014051 AXIN2 PIK3R2 HEL-S-91n FZD3 MAPK10 CSNK2B PTGS2 PSMC6 PSMC4 CASP12 PPP3R1 PPP3R2 HEL-S-162eP SLC25A5 HEL-S-61 PSMD9 PSMD6 PSMD4 PSMD3 PSMD1 DKK2 CYBB NRBF2 ATG2B WIPI2 PSMA4 ATG14 PSMA2 KNS2 PSMA8 PSMB6 ATG2A PSMB2 PSMB3 PSMC1 TNF CDK5R1 HEL-S-276 PPIF RTN3 CDK5 SLC25A4 KLC4 KLC3 KLC2 NAE1 GSK3B SHFM1 MCU ATP2A1 ADRM1 DKK4 PIK3CD SLC25A31 PIK3R3 ULK2 CACNA1C PIK3R1 APH1B NRAS GRIN2B CALML6 GRIN1 CALML3 CALML4 ULK1 RAF1 PIK3CA ATP2A2 RELA MAPK1 APOE CACNA1F MAPK3 HSD17B10 KIF5A CACNA1S MTOR PLCB3 PLCB4 PLCB1 PLCB2 CALM1 MAPK8 IL1A MAP3K5 FZD5 WNT2B IRS1 TRAF2 FRAT1 TNFRSF1A IL6 WNT5B AXIN1 WNT16 PIK3R4 MAPK9 DVL1 DVL2 DVL3 FRAT2 WNT1 WNT3 WNT4 WNT10B APC2 CSNK1A1L WNT10A APAF1 BAD WNT3A IL1B WNT7B INSR WNT7A NFKB1 APC CHUK IKBKB CSNK2A1 CSNK2A3 CSNK2A2 TUBAL3 BECN2 MME TUBB8 VEGFA VEGFR2 SIGNALING%WIKIPATHWAYS_20260710%WP3888%HOMO SAPIENS VEGFA VEGFR2 signaling NFKBIA TUBA1C MYH9 FOXO1 NCF1 FYN NCF2 NCK1 PRKCA EIF2A RAB5A ATF4 PPP3CA ARHA NCL HDAC7 EZR tal-1 RCAN1 SHB CALU GLUD1 MMP14 DPM1 IQGAP1 TEAD4 PRKCE PTK2B BMX NOX4 ADAM10 FRS2 EPHA2 EIF3S3 PABPC1 EIF3F EIF3D SET ACACB PLCG1 XB ERN1 TXNIP BRD4 SHC2 TPM3 MYL2 ANXA1 PTPN1 SDCBP CYR61 AP2A1 AMOT CYCS FADD EGR1 HEL-S-78p MOV10 DKK1 SRP54 HBD TMSB10 GATA2 NFATC1 CCRL2 S1PR1 BMP2 ITCH HEL114 MMRN2 PRKCI ITGAV HRAS FOXO4 TXN PRKCZ MAP2K1 MAP2K2 PDPK1 VAV2 ADAM9 RAPGEF1 PPP2CA CRK CCT7 LIMK1 SHC1 SRC PXN PIK3R2 RAP1A CSK TAOK2 ALB GRB2 MLST8 HEL107 PTGS2 FGA AKT1S1 BIRC5 FUT1 EIF4E PRKD2 RPS6KA5 PRKD1 HEL-S-162eP VPS39 DECR1 STAT3 MAPKAP1 MAPKAPK2 HEL-S-68p RICTOR HEL-S-2a HEL-S-15 HEL-S-87p EIF4G1 PTPN6 FLNB HDAC5 NAPA PSMD4 F3 AP2S1 CYBB HEL-S-133P HEL-S-102 MEF2C ENG RAB4A RAB11A OCRL STAT1 CCND1 KDR GSK3B TNFRSF10C PRKAA1 RAC1 PRKAA2 RPS6 RPL5 TRAF3IP2 FBXW11 RPL7 NOTCH4 PNP BMP10 DLL4 RPL18A EPHB2 PIK3R1 LUC7L UBAP2L CHAC1 RPS11 ATP6V1E1 CREB1 NUMB IER5 ACOT9 TMEM170A SND1 ERG KATNAL2 EWSR1 TNFRSF25 BIN1 RPL27 RPL26 RAF1 PFN1 PIK3CA ATP6V0D1 FLII SH2D2A SLC8A1 GJA1 GIGYF2 FXR2 DHX36 HLX MYO6 SIAH2 PLA2G5 MICAL2 PRRC2C RELA LARP7 ACACA FLT1 CACNA2D1 SRPK1 ACKR3 HEL-S-128m CAMKK2 INPP4B EPRS1 CTGF HYOU1 PAK1 ADRB2 DHX29 FARSB AFDN ARF4 NRP2 MAPK1 FAF1 VEGFA KCNC3 CCDC124 EEA1 TMSB4X RPLP2 HEL2 MAPK3 ELOA SH3BGRL3 CTNNA1 ELOC DKFZp686L0365 CLIC1 PRKCB CGNL1 DUSP5 NFATC2 SLC2A14 SSR4 SSR3 MMP10 FJX1 ARF6 MTOR PLCB3 PTMA KANK1 CRIP2 RPS6KB1 SLC7A1 APOLD1 KL FGD5 HDAC1 GPC1 AAG1 COPG1 SPIRE1 GPX1 FHOD1 CTNND1 PLOD3 RPL10A GRB10 ATF2 TMOD1 SEMA6D CREBBP DOK1 ARMCX1 MAPK8 HGS RAB37 hEMMPRIN MAPKAPK5 ZNF555 DSC1 LRRC59 MAP3K5 PSMD11 HTRA1 QK3 MAP2K6 MAP2K3 IGFBP7 MAP2K4 ZC3H15 PRKG1 HEL-S-94n JUN SDF2L1 HEL-S-84 TBCA MMP2 TFCP2 HMGB1 NR4A3 TPP1 MAPK14 GRSF1 MAPK12 C15orf39 FHL2 RPL13a CBL NRARP FOXO3A CSRP2 LDB2 RND1 CAPZB LRRFIP2 ADAMTS9 TRPC3 PTPN11 BCL2 ARHGEF15 SHROOM2 BCL2L1 HEL164 HBEGF EPN1 SARS1 MAPK9 SLC25A11 P4HA2 PPM1G ITGB3 DNAJB4 FAM120A WASF1 ABCF2 TRPC1 SLC25A25 PDE4DIP CDC42BPB SELE FMNL3 MYO1C CNP PTPN9 CLTC NFKB1 CXCL8 TFAM CCL2 MDM2 LMAN1 HEL-S-99n SYNJ1 ITGB1 ROCK1 ROCK2 DNAJB9 ACTG1 TUBB8 PLAUR CDC42 TOLL LIKE RECEPTOR SIGNALING%WIKIPATHWAYS_20260710%WP75%HOMO SAPIENS Toll like receptor signaling NFKBIA MAPK10 CXCL9 MAPK3 TBK1 LBP CD14 IRF3 CD40 CASP8 CXCL11 IFNA5 IFNA4 IFNA7 RIPK1 IFNA6 CCL4 FADD IFNA1 CCL3 IFNA2 IKBKE IFNA8 TLR5 IFNA21 IFNAR2 TLR4 IFNA13 IFNA14 MAPK8 IFNA16 IFNA17 IRF7 TLR7 MAP2K6 MAP2K3 IFNA10 MAP2K4 IFNAR1 JUN FOS MAPK14 NFKBIB MAPK12 MAPK13 MAPK11 MAP3K7 IL6 TRAF6 opn MAPK9 IFNB1 TNF STAT1 TICAM2 AKT3 RAC1 TICAM1 IL1B TRAF3 NFKB1 CXCL8 TAB3 MAP2K1 IL12B MAP2K2 CHUK IRAK4 MAP3K7IP1 IKBKB TIRAP TLR1 MAP3K8 TLR9 TLR8 IKBKG TLR3 IRAK1 CD80 IL12A RELA LY96 CCL5 MYD88 MAPK1 TRANS SULFURATION PATHWAY%WIKIPATHWAYS_20260710%WP2333%HOMO SAPIENS Trans sulfuration pathway MTR CBS pcap CTH GCLM MAMMARY GLAND DEVELOPMENT PUBERTY STAGE 2 OF 4%WIKIPATHWAYS_20260710%WP2814%HOMO SAPIENS Mammary gland development puberty stage 2 of 4 AREG CCND1 TIMP1 HEL113 ERBB2 MYC PGR FOSL1 EGF KCNQ2 AND KCNQ3 RELATED EPILEPSY%WIKIPATHWAYS_20260710%WP5599%HOMO SAPIENS KCNQ2 and KCNQ3 related epilepsy SNAP25 BACE1 KCNQ2 RAB11A KCNQ3 VAMP2 RAB1A ZNF547 SCN8A AKAP5 TRAPPC3 GIGYF1 TRAPPC6B SCN2A KCNQ5 SCN4B STX1A CALM1 CAMK2A FGF13 FGF12 PRKCE PRRT2 DAG1 NEDD4 MEVALONATE ARM OF CHOLESTEROL BIOSYNTHESIS PATHWAY%WIKIPATHWAYS_20260710%WP4190%HOMO SAPIENS Mevalonate arm of cholesterol biosynthesis pathway MVD FDFT1 FDPS HMGCS1 GGPS1 HMGCR MVK IDI2 ACAT1 ACAT2 HMGCL PMVK CELLS AND MOLECULES INVOLVED IN LOCAL ACUTE INFLAMMATORY RESPONSE %WIKIPATHWAYS_20260710%WP4493%HOMO SAPIENS Cells and molecules involved in local acute inflammatory response ITGA4 KNG1 IL1A VCAM1 SELPLG TNF C6 C7 HEL-S-62p ITGB1 SELP CXCL8 IL6 SELENIUM METABOLISM AND SELENOPROTEINS%WIKIPATHWAYS_20260710%WP28%HOMO SAPIENS Selenium metabolism and selenoproteins SP3 SARS1 GPX2 CTH GPX4 FABP1 GPX3 TXNRD2 GPX1 RPL30 NFKB1 HEL-S-134P SELENOF SELENOK NFE2L2 SELENOI SELENOH SEPHS1 SEPHS2 PSTK EEFSEC POU2F1 TRNAU1AP SELENOO SP1 SEPSECS SELENOP SELENON CREM SELENOM SARS2 SELENOW SELENOV SELENOT MSRB1 JUN SELS DIO1 FOS RELA GPX6 MEASLES VIRUS INFECTION%WIKIPATHWAYS_20260710%WP4630%HOMO SAPIENS Measles virus infection NFKBIA MAPK10 CSNK2B IRF3 OAS2 IRF9 CLEC4M IKBKE MX1 TLR4 STAT3 TLR7 CD209 NFKBIB JAK1 EIF2AK1 RAB9A EIF3S3 OAS1 STAT1 CCND1 PIK3CD PIK3R3 EIF2S1 PIK3R1 EIF2AK2 CCNE1 PIK3CA IL2RA RELA IL2RB CCNE2 CDK2 TBK1 TRADD CASP9 CASP8 IFNA5 CASP3 CYCS IFNA4 IFNA7 FADD IFNA6 IFNA1 IFNA2 IFNA8 IFNA21 IFNAR2 IFNA13 IFNA14 MAPK8 IFNA16 IL1A STAT2 IFNA17 IRF7 BAK1 IFNA10 IFNAR1 CD3G JUN CDKN1B CD3E IFIH1 BBC3 FOS CCND3 IL2 CCND2 IL2RG HEL-S-72p MAP3K7 IL6 TNFSF6 JAK3 STAT5B TRAF6 BCL2 TYK2 BAX BCL2L1 MAPK9 IFNB1 APAF1 BAD HEL70 IL1B TRAF3 NFKB1 NFKB2 CD3D TNFAIP3 IL12B CDK6 TP73 CDK4 CHUK IRAK4 CD46 IKBKB TLR9 IKBKG CSNK2A1 CSNK2A3 IRAK1 CSNK2A2 LNIR IL12A HSPA2 EIF2AK4 PIK3R2 ADAR OAS3 RCHY1 FCGR2B RAB9B HSPA1A MAVS MYD88 RIGI T CELL ANTIGEN RECEPTOR TCR PATHWAY DURING STAPHYLOCOCCUS AUREUS INFECTION%WIKIPATHWAYS_20260710%WP3863%HOMO SAPIENS T cell antigen receptor TCR pathway during Staphylococcus aureus infection NFKBIA PTPRC PDCD1 MAPK3 GRB2 FYN ZAP70 NCK1 NFATC2 LCK RRAS CALM1 MAP3K14 CSF2 JUN FOS PRKCQ PTPN6 LCP2 IL2 CBL LAT MAP3K7 IFNG MAPK9 TNF CD40LG GSK3B PLCG1 NFKB1 CD3D MAP2K1 GRAP2 MAP2K2 BCL10 ICOS CHUK CDK4 IKBKB CD8A MAP3K8 CARD11 IKBKG IL10 SOS1 RAF1 PIK3CA IL4 IL5 CTLA4 DAG1 ITK CHP1 AHSA1 PAK1 RELATIONSHIP BETWEEN INFLAMMATION COX 2 AND EGFR%WIKIPATHWAYS_20260710%WP4483%HOMO SAPIENS Relationship between inflammation COX 2 and EGFR EGFR PTGER4 MAPK3 PTGER1 PTGS2 PTGER2 PTGER3 PIK3CA SRC PLA1A AKT3 PIK3CD HRAS NRAS MAPK1 FRAGILE X SYNDROME%WIKIPATHWAYS_20260710%WP4549%HOMO SAPIENS Fragile X syndrome GRIP2 ALDH3A2 KCND2 ALDH5A1 MAP1B CNR1 CPT1A TBC1D7 RAP1GAP GRB2 EPS8L1 GABRB2 MLST8 ARHGAP32 AGO2 FYN PTPN5 AP2A1 PRKCA AKT1S1 MTOR RPS6KB1 PPP3CA GPHN PLCB1 CAMK4 DLGAP3 EIF4E CAMK1 CLTB PICK1 CAMK2A HCN1 EPHA4 PPP2R5B CLTCL1 CLTA GAD1 CDKN2A PRKAR1A EIF4G1 EIF4EBP2 DICER1 EEF1A1 AP2S1 PTPN11 TARBP2 APP AP2M1 ARAF RPTOR TSC2 TTI1 AKAP5 PLCG1 PTEN CYFIP1 CLTC TSC1 SH3GL3 FMR1 DEPTOR MAP2K1 SYNGAP1 MAP2K2 AGAP2 CREB1 NTRK2 HOMER1 BDNF GRIN2B DKFZp762B153 GRIN1 ARC SOS1 RAF1 RHEB DLG4 NF1 SHC1 ABAT SRC GRIP1 DAG1 SHANK1 CYFIP2 EIF4A1 ABCD3 GRIA2 KCNC1 SH3GL1 DUSP3 MMP9 MAPK1 SICKLE CELL DISEASE%WIKIPATHWAYS_20260710%WP5604%HOMO SAPIENS Sickle cell disease IL1B HBA2 IL18 HBB TLR4 SULINDAC METABOLIC PATHWAY%WIKIPATHWAYS_20260710%WP2542%HOMO SAPIENS Sulindac metabolic pathway CYP1A2 CYP1B1 MSRA MSRB2 MSRB3 G1 TO S CELL CYCLE CONTROL%WIKIPATHWAYS_20260710%WP45%HOMO SAPIENS G1 to S cell cycle control CCNE2 CDK2 PRIM2 PRIM1 POLA2 ORC6 RB1 ORC3 CDKN1A ORC2 CDC2 MCM7 ORC1L ATF6B CCNH CDKN1B TFDP1 CDKN2A POLE TFDP2 MCM3 MCM5 MCM6 CCND3 MCM2 CCND2 MYC CDC45 E2F2 E2F3 CDKN2D WEE1 CDK7 POLE2 RPA3 MNAT1 CDKN1C RPA1 CCND1 CREB3 CREB3L3 CREB3L4 GADD45A CCNG2 CDKN2B MDM2 CDKN2C ATM CREB1 PCNA CDK6 MYT1 CDK4 CCNE1 CCNB1 WNT BETA CATENIN SIGNALING INHIBITORS IN CURRENT AND PAST CLINICAL TRIALS%WIKIPATHWAYS_20260710%WP5442%HOMO SAPIENS Wnt Beta catenin signaling inhibitors in current and past clinical trials LRP5 CREBBP LRP6 PORCN 16P13 11 COPY NUMBER VARIATION SYNDROME %WIKIPATHWAYS_20260710%WP5502%HOMO SAPIENS 16p13 11 copy number variation syndrome DCTN6 DCTN1 DCTN4 PLAG1 CEP170 ACTR1B PLAGL1 DISC1 KIAA0753 BMERB1 OFD1 NDE1 ABCC6 MARF1 DCP1A CEP20 ACTR10 ABCC1 DCP2 RAPGEF4 PCM1 PLK1 GATA3 PAFAH1B1 RAP1A SIGNALING LIPIDS%WIKIPATHWAYS_20260710%WP5584%HOMO SAPIENS Signaling lipids ALOX15 CYP27A1 HPGD EPHX2 CYP4F2 ALOX12 LTC4S PTGS2 CYP7A1 CYP2C9 PLA2G1B FADS2 GPX4 PTGES CYP2B6 PLA1A COX1 CYP7B1 PLCB1 PRXL2B CYP8B1 ALOX5 VITAMIN D IN INFLAMMATORY DISEASES%WIKIPATHWAYS_20260710%WP4482%HOMO SAPIENS Vitamin D in inflammatory diseases NFKBIA NR1i1 CHUK IKBKB RXRA IKBKG TNF MAP2K6 MAP2K3 NR3C1 SMAD4 MAP3K1 MAPK14 RELA PPP3CA PPP3R1 NFKB1 IL6 NFATC1 MED14 EICOSANOID SYNTHESIS%WIKIPATHWAYS_20260710%WP167%HOMO SAPIENS Eicosanoid synthesis ALOX15 PTGIS ALOX12 PLA2G4B LTC4S PTGS2 ALOX15B PTGS1 PTGES PLA2G5 PLA2G6 ALOX5AP PRXL2B ALOX5 NUCLEAR RECEPTORS%WIKIPATHWAYS_20260710%WP170%HOMO SAPIENS Nuclear receptors RORC NR1B3 NR2F6 NR1i2 NR3A2 RARA RARB PGR NR3C1 RORA ESRRA NR2E1 NR2C2 PPARG ESRRB NR2F1 NR1I3 NR1i1 NR0B1 NR2F2 NR5A1 NR5A2 NR1H2 RXRA RXRB NR1H3 NR1C2 ROR1 THRA RXRG NR1C1 NR1A2 NR1D2 HNF4A RIOK1 AND RIOK2 IN EGFR AND PI3K MEDIATED TUMORIGENESIS%WIKIPATHWAYS_20260710%WP3873%HOMO SAPIENS RIOK1 and RIOK2 in EGFR and PI3K mediated tumorigenesis MTOR EGFR AKT3 MAPKAP1 RPL11 PTEN MLST8 RIOK2 RICTOR RIOK1 FOXO3A PIK3CA ECTODERM DIFFERENTIATION%WIKIPATHWAYS_20260710%WP2858%HOMO SAPIENS Ectoderm differentiation ELOVL2 LHX1 FYN FZD8 GLB1 NR2F2 CDH8 ARHGDIG CDH6 CELSR2 CDON KCNK10 NR1C2 TLE5 MZF1 ASTN1 LY6E ARX STC1 TNLG7C ARHGAP15 ZBTB2 RHPN1 ST8SIA4 HESX1 ZBTB7B GAS2L1 GREB1 POU2F2 GLI3 PAN2 PTPRB PPFIBP2 MAFB NUMA1 NF2 HMGB2 WDR44 TBL1X SIX6 BOC RAB8B SMURF1 BCAS3 SORCS1 BAZ1A BMPR1A FOXL1 SERPINB6 SKIL CLDN11 ARHGAP10 KIFC3 RUTBC3 STX16 RRBP1 CLVS1 CAP2 TTC14 C1GALT1 PTPN13 KRT6A VAX2 ZBTB16 RIT1 ZNF219 PDE7A SNCA MYORG PRKAG2 ELOVL4 HDAC10 OGT PLXNA2 UBTF RGMA SDCBP DMD CTNNA2 NLGN1 AHI-1 JUP SOCS2 TRPM2 SOX2 CTNND2 H2BC9 TFAP2A GATA6 TFAP2C FZD5 FZD4 ZFHX4 FHL2 SCHIP1 MYC LDB2 MKS1 NFATC1 SHH NLK BMP4 TOX3 TNFRSF11B WNT1 BCOR TCF7L1 SMAD4 FOXA2 CCL2 SPRY2 FGFR2 CTBP1 PAX3 ROR2 TCF3 PIM1 ENDOTHELIN PATHWAYS%WIKIPATHWAYS_20260710%WP2197%HOMO SAPIENS Endothelin pathways NPY1R GNAI1 PRKCA GNA15 COX2 MYLK PLCB1 EDN1 CALCRL HEL-S-14 RIIAD1 CALM1 RAMP1 ECE1 MAP2K1 GNB5 NPY CAD GNAS ADRA1A EDNRA CALCA RAF1 EDNRB ATP2A2 PTGIR HEL-S-7a GNG13 MYL1 ADRB1 MAPK1 GLYCEROLIPIDS AND GLYCEROPHOSPHOLIPIDS%WIKIPATHWAYS_20260710%WP4722%HOMO SAPIENS Glycerolipids and glycerophospholipids AGPAT4 PTDSS2 PNPLA3 GPAM PNPLA2 PLA2G1B PTDSS1 GPAT4 CDIPT DGAT1 CHKB CRLS1 DGAT2 PEMT CHPT1 DGKZ CDS1 PISD HIPPOCAMPAL SYNAPTOGENESIS AND NEUROGENESIS%WIKIPATHWAYS_20260710%WP5231%HOMO SAPIENS Hippocampal synaptogenesis and neurogenesis NRXN3 BCL2 CREB1 SYT2 NGF NRXN2 BDNF CAMKK1 HNRNPL NRXN1 RPS6KA1 PPARGC1A PRKCA NCAM1 MAPK14 CCND2 CAMK4 PRL CAMKK2 DRD1 RPS6KA5 CALM1 CAMK2A MAPK1 EXTRACELLULAR VESICLE MEDIATED SIGNALING IN RECIPIENT CELLS%WIKIPATHWAYS_20260710%WP2870%HOMO SAPIENS Extracellular vesicle mediated signaling in recipient cells EGFR TGFBR1 TGFBR2 TGFBR3 ERBB2 CD133 RAF1 TGFA SMAD2 TGFB1 MTOR SMAD4 MFGE8 WNT3A DKK4 HRAS AXIN1 TSPAN8 APC HGF NRAS EPO RECEPTOR SIGNALING%WIKIPATHWAYS_20260710%WP581%HOMO SAPIENS EPO receptor signaling MAP2K2 PTPRC GRB2 MAPK3 PTPRU SOS1 RAF1 EPOR SHC1 IRS1 STAT1 SRC CISH SOCS1 EPO STAT5B MAP2K1 STAT3 MAPK1 MIRNA REGULATION OF PROSTATE CANCER SIGNALING%WIKIPATHWAYS_20260710%WP3981%HOMO SAPIENS miRNA regulation of prostate cancer signaling CDKN1A MAP2K2 NFKBIA BCL2 MDM2 CREBBP GRB2 FOXO1 KLK3 IKBKG SOS1 RAF1 PIK3CA CDKN1B MTOR CASP9 CCND1 GSK3B AKT3 BAD NFKB1 PDGFA MAP2K1 MAPK1 GLYCOLYSIS AND GLUCONEOGENESIS%WIKIPATHWAYS_20260710%WP534%HOMO SAPIENS Glycolysis and gluconeogenesis HEL-S-133P HEL-S-281 G6PC1 HEL-S-49 PFKL SLC2A4 PC HK2 HEL-S-32 GCK PFKM HEL-S-30 PFKP SLC2A2 SLC2A3 ENO1 ENO2 ENO3 HK3 MPC1 MPC2 DLAT HEL-S-162eP PGAM1 PGAM2 HEL-S-68p ALDOB GOT2 DLD FBP1 FBP2 HEL-S-87p PCK1 PDHA1 PKLR MDH2 RESISTIN AS A REGULATOR OF INFLAMMATION%WIKIPATHWAYS_20260710%WP4481%HOMO SAPIENS Resistin as a regulator of inflammation NFKBIA MAPK3 PLCD3 PLCD4 TNF PLCB3 PLCB4 AKT3 PLCG1 RETN PLCB1 PIK3CD PLCB2 NFKB1 CXCL8 PLCG2 IL12B CHUK IKBKB IKBKG PIK3CA IL12A MAPK14 RELA PLCE1 IL6 MAPK1 IL19 SIGNALING%WIKIPATHWAYS_20260710%WP5422%HOMO SAPIENS IL19 signaling IL19 COL1A1 MAPK8 MAPK3 CXCR4 MUC5AC TNF IL4 CCNB1 TGFB1 STAT1 MAPK14 ACTA2 RAC1 TNFRSF1A NFKB1 SOCS1 JAK1 SOCS5 CCL11 IL20RA STAT3 IL20RB MAPK1 FGFR4 P G388R SIGNALING%WIKIPATHWAYS_20260710%WP5428%HOMO SAPIENS FGFR4 p G388R signaling FGFR4 IL10 STAT3 CREATINE PATHWAY%WIKIPATHWAYS_20260710%WP5190%HOMO SAPIENS Creatine pathway HEL-S-20 SLC6A8 HEL-S-29 CHOLESTEROL METABOLISM%WIKIPATHWAYS_20260710%WP5304%HOMO SAPIENS Cholesterol metabolism PCSK9 STARD3 PLTP LIPG SORT1 APOE LPA APOB ABCA1 LIPA APOH NPC1 NPC2 APOC1 STAR CYP7A1 DGAT1 CYP51A1 MGAT1 CYP27A1 NPC1L1 FABP2 CD36 SLC27A4 MVK MSMO1 HSD17B7 ACAT2 SCARB1 TM7SF2 DKFZp434B2017 ABCG8 EBP ABCG5 PMVK SC5D LBR FDFT1 MYLIP FDPS HMGCS1 HMGCR ABCB11 PBR LDLR DHCR24 ANGPTL3 LRPAP1 APOC3 SQLE SOAT1 CIDEB VAPA MVD DHCR7 MTTP APOA2 LPL APOA4 ANGPTL8 LIPC APOC2 PURINE METABOLISM AND RELATED DISORDERS%WIKIPATHWAYS_20260710%WP4224%HOMO SAPIENS Purine metabolism and related disorders PAICS ADSL HEL-S-70p DGUOK TPMT MOCOS AMPD1 PFAS RRM2B APRT IMPDH1 ADSS AOX1 ADA PNP XDH BENZENE METABOLISM%WIKIPATHWAYS_20260710%WP3891%HOMO SAPIENS Benzene metabolism GSTM1 EPHX1 CYP2E1 DHDH NQO1 MPO OXIDATION BY CYTOCHROME P450%WIKIPATHWAYS_20260710%WP43%HOMO SAPIENS Oxidation by cytochrome P450 CYP2R1 CYP3A43 CYP7B1 CYP2A7 CYP2A6 CYP26C1 CYP4A11 CYP3A4 CYP7A1 CYP17A1 CYP3A7 CYP2A13 CYP46A1 CYP2F1 CYP51A1 CYP4Z1 CYP1B1 CYP4A22 CYP8B1 CYP27A1 CYP2U1 CYP2W1 CYP2E1 CYP24A1 CYP20A1 CYP2C19 CYP4F22 CYP2C18 CYP27B1 CYP2B6 CYP4X1 CYP11A1 CYP2J2 POR CYP4F2 CYP4F3 CYP4F11 CYP4F8 CYP4F12 CYP26A1 CYP2C9 CYP27C1 CYP11B2 CYP2S1 CYP1A2 CYP1A1 CYB5R1 CYB5R4 CYB5B CYB5R3 CYP26B1 CYP4V2 MICROGLIA PATHOGEN PHAGOCYTOSIS PATHWAY%WIKIPATHWAYS_20260710%WP3937%HOMO SAPIENS Microglia pathogen phagocytosis pathway CYBB ITGAM NCF1 NCF2 C1QB NCF4 C1QA RAC1 CYBA PIK3CD RAC3 PIK3R3 C1QC PIK3R1 VAV3 TREM1 PLCG2 VAV2 PIK3CA SYK VAV1 PIK3R2 TYROBP NCKAP1L PTPN6 ARPC1B FCGR1A LAT LYN FCER1G SIGLEC7 ETHANOL METABOLISM PRODUCTION OF ROS BY CYP2E1%WIKIPATHWAYS_20260710%WP4269%HOMO SAPIENS Ethanol metabolism production of ROS by CYP2E1 MAP2K2 MAPK8 CYP2E1 SP1 MAFG MAFF MAFK NFE2L2 MAP2K1 FAMILIAL HYPERLIPIDEMIA TYPE 5%WIKIPATHWAYS_20260710%WP5112%HOMO SAPIENS Familial hyperlipidemia type 5 PLTP GPIHBP1 SEL1L APOA2 LPL APOA4 LDLR APOA5 LMF1 LIPC APOC2 TARGETED THERAPY IN BREAST CANCER%WIKIPATHWAYS_20260710%WP5496%HOMO SAPIENS Targeted therapy in breast cancer EGFR PIK3R4 PIK3R5 ERBB4 ERBB2 MAPK3 RAF1 PIK3CA PIK3C2G PIK3R2 AKT3 PIK3C2B PIK3CD PIK3R3 HRAS PIK3R1 ERBB3 NRAS MAPK1 OXIDATIVE PHOSPHORYLATION%WIKIPATHWAYS_20260710%WP623%HOMO SAPIENS Oxidative phosphorylation NDUFA5 NDUFA11 NDUFA10 ATP5G1 HEL-S-271 NDUFC2 NDUFC1 NDUFS6 NDUFS5 NDUFS4 NDUFS1 ND3 ND2 ND5 ND4 NDUFB9 ND6 NDUFB8 NDUFB7 NDUFB6 NDUFB5 NDUFB4 ATP6 ND1 ATP5MC2 NDUFB2 ATP5J NDUFB1 ATP5MC3 ATP5H HEL-S-123m NDUFV3 NDUFV2 ATP5MG ATP5MF ATP5ME DMAC2L NDUFA7 NDUFA6 ATP5PB NDUFA3 NDUFA2 ND4L ATP5F1D ATP5F1E NDUFAB1 ATP5PO NDUFS8 NDUFS3 COXFA4 NDUFA9 NDUFB10 COXFA4L2 ATP6AP2 GABA RECEPTOR SIGNALING%WIKIPATHWAYS_20260710%WP4159%HOMO SAPIENS GABA receptor signaling ALDH9A1 GABRB3 AP2M1 GABBR2 GABRB2 GABRB1 AP2A1 GABRA3 AP2A2 GPHN GABBR1 SLC32A1 GABRE GABRQ GABRA2 GABRP GABRA6 GABRA5 GAD1 GABRA4 ABAT SLC6A11 GABRG3 GABRG1 AP2S1 GAD2 ACUTE MYELOID LEUKEMIA%WIKIPATHWAYS_20260710%WP5293%HOMO SAPIENS Acute myeloid leukemia RPS6KB2 CEBPE MAPK3 GRB2 CD14 RUNX1 MTOR JUP RPS6KB1 PML STAT3 PER2 MPO NR1C2 CSF2 KIT CEBPA MYC CCNA2 SPI1 STAT5B SOS2 LEF1 IL3 BCL2A1 ITGAM RARA ARAF CSF1R TCF7L2 TCF7L1 CCND1 AKT3 BAD RUNX1T1 ZBTB16 PIK3CD PIK3R3 NFKB1 HRAS PIK3R1 MAP2K1 NRAS MAP2K2 EIF4EBP1 CHUK IKBKB FLT3 IKBKG SOS1 RAF1 PIK3CA PIK3R2 RELA FCGR1A PIM1 PIM2 MAPK1 GLUCOSE HOMEOSTASIS%WIKIPATHWAYS_20260710%WP661%HOMO SAPIENS Glucose homeostasis INS DISORDERS OF FRUCTOSE METABOLISM%WIKIPATHWAYS_20260710%WP5178%HOMO SAPIENS Disorders of fructose metabolism SLC2A2 GLYCTK SORD SLC5A1 G6PC1 KHK HEL-S-49 PFKL ALDOB FBP1 HEL-S-53e TRYPTOPHAN CATABOLISM LEADING TO NAD PRODUCTION%WIKIPATHWAYS_20260710%WP4210%HOMO SAPIENS Tryptophan catabolism leading to NAD production AADAT NMNAT3 NMNAT2 NMRK1 NAPRT HAAO NMNAT1 NADSYN1 TDO2 KYNU NMRK2 AFMID KMO HEL-S-90n NAMPT IDO1 G13 SIGNALING%WIKIPATHWAYS_20260710%WP524%HOMO SAPIENS G13 signaling PIP4K2A MAPK10 PKN1 RTKN SH3RF1 CFL2 ARHGDIB RHPN2 MYBPH CIT RPS6KB1 HEL-S-80p RAC1 TNK2 ARHA CYFIP1 PIK3CD CALM1 ARHGDIG PIK3CA PFN1 IQGAP1 LIMK1 HEL-S-15 PIK3R2 GNA13 ROCK1 ARHGEF1 ROCK2 WAS MYL1 WASL CDC42 SPLICING FACTOR NOVA REGULATED SYNAPTIC PROTEINS%WIKIPATHWAYS_20260710%WP4148%HOMO SAPIENS Splicing factor NOVA regulated synaptic proteins CAV2 STX2 MAPK9 RAP1GAP GABBR2 KCNMA1 KCNQ2 GRIK2 EFNA5 CHL1 NCDN PLCB4 MAP4 CLASP1 AGRN NTNG1 KCNJ6 GPHN CADM3 CASK SNW1 DAB1 TERF2IP PRKCZ CAMK2G GRIN2B ATP2B1 GRIN1 CSN3 CDH2 MAPK4 CADM1 BRAIN DERIVED NEUROTROPHIC FACTOR BDNF SIGNALING%WIKIPATHWAYS_20260710%WP2380%HOMO SAPIENS Brain derived neurotrophic factor BDNF signaling NFKBIA NGFR SORT1 MAPK10 CNR1 GRB2 NCK2 NCF1 FYN NCF2 RANBP9 NCK1 EIF4E RASGRF1 NTRK1 RPS6KA5 STAT3 NFATC4 LINGO1 PTK2B EEF2 HEL-S-15 FRS2 EIF2S2 MEF2C CDKL5 CDK5R1 CDK5 STAT1 ACACB GSK3B PLCG1 PRKAA1 RAC1 PRKAA2 RPS6 EIF2S1 PIK3R1 EIF4EBP1 CREB1 NTRK2 NGF BDNF GRIN2B GRIN1 SHC2 RAF1 TIAM1 SQSTM1 CRTC1 SHC4 GRIP1 RELA GRIA2 MAP3K2 MAPK1 GRIA3 NTF3 KSR1 MAPK3 GABRB3 MTOR CASP3 RPS6KB1 NTRK3 CAMK4 CAMK1 SIRPA FRS3 DOK5 KCNN2 CAMK2A DOCK3 YBX1 PTPRF MAPK8 KCNA3 IGF2BP1 SH2B2 SH2B1 KIDINS220 ARHG MARCKS JUN IRS1 NCAM1 MAPK14 FOXO3A ADAM17 STAT5B TRAF6 PTPN11 MAPK9 RPS6KA1 TSC2 SYN1 MAP3K1 BAD CYFIP1 NFKB1 HRAS APC VAV3 MAP2K1 MAP2K2 PDPK1 CHUK IKBKB VAV2 PPP2CA IKBKG CSNK2A1 SHC3 SHC1 SRC PIK3R2 RAP1A CDH2 MAPK7 MAP2K5 CDC42 DEVELOPMENT OF PULMONARY DENDRITIC CELLS AND MACROPHAGE SUBSETS%WIKIPATHWAYS_20260710%WP3892%HOMO SAPIENS Development of pulmonary dendritic cells and macrophage subsets FLT3LG IRF4 IKZF1 IRF8 RUNX2 BATF3 TPO CSF2 GIG8 TCF4 CSF1 SPI1 STAT3 JAK STAT SIGNALING AND ARTD FAMILY MEMBERS%WIKIPATHWAYS_20260710%WP5528%HOMO SAPIENS JAK STAT signaling and ARTD family members DTX3L STAT1 SKP1 PARP14 HDAC2 HDAC3 BTRC PARP11 RBX1 STAT3 1Q21 1 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260710%WP4905%HOMO SAPIENS 1q21 1 copy number variation syndrome GJA3 PRKAB2 GJA8 PRKAB1 GJA5 NBPF12 CHD1L F11R BCL9 TJP1 PYGO2 GJA1 ACP6 AMELX TJP3 PRKAA1 PYGO1 PRKAA2 PRKAG1 PRKAG2 AFDN FMO5 PRKAG3 GLYOXYLATE METABOLISM%WIKIPATHWAYS_20260710%WP5166%HOMO SAPIENS Glyoxylate metabolism HEL-S-133P DAO SLC26A1 PXMP2 HAO1 HOGA1 AGXT PRODH2 GOT2 NON HOMOLOGOUS END JOINING%WIKIPATHWAYS_20260710%WP438%HOMO SAPIENS Non homologous end joining PRKDC WRN POLM POLL XRCC5 NHEJ1 RALA DOWNSTREAM REGULATED GENES%WIKIPATHWAYS_20260710%WP2290%HOMO SAPIENS RalA downstream regulated genes EXOC2 RALBP1 RALA RAC1 RAC3 HRAS EXOC8 YBX3 CDC42 NRAS PHOTODYNAMIC THERAPY INDUCED NFE2L2 NRF2 SURVIVAL SIGNALING%WIKIPATHWAYS_20260710%WP3612%HOMO SAPIENS Photodynamic therapy induced NFE2L2 NRF2 survival signaling SRXN1 HMOX1 MAPK8 EPHX1 KEAP1 JUN FOS HEL-S-22 MAPK14 NQO1 ABCC6 MAPK12 MAPK13 ABCG2 CES1 MAPK11 ABCC3 GCLC GCLM NFE2L2 NQO2 ABCC2 NOVEL INTRACELLULAR COMPONENTS OF RIG I LIKE RECEPTOR PATHWAY%WIKIPATHWAYS_20260710%WP3865%HOMO SAPIENS Novel intracellular components of RIG I like receptor pathway NFKBIA MAPK10 TBK1 IRF3 TRADD CASP8 RIPK1 FADD IFNA1 IKBKE SNW1 DKFZp686F0183 TBKBP1 DHX58 MAPK8 TRIM25 IRF7 TANK ATG12 IFNE IFNK CASP10 IFIH1 TRAF2 MAPK14 NFKBIB MAPK12 MAPK13 MAPK11 MAP3K7 IFNG TRAF6 DDX3Y DDX3X AZI2 MITA MAPK9 SIKE1 RNF125 PIN1 IFNB1 TNF OTUD5 MAP3K1 TRAF3 NFKB1 CXCL8 CYLD ISG15 CHUK IKBKB CXCL12 IKBKG RELA NLRX1 MAVS RIGI CHOLESTEROL BIOSYNTHESIS PATHWAY IN HEPATOCYTES%WIKIPATHWAYS_20260710%WP5329%HOMO SAPIENS Cholesterol biosynthesis pathway in hepatocytes CYP27A1 ELOVL5 ELOVL2 ABCA1 ACSL1 ACSL3 PLPP6 FADS2 MVK IDI2 MSMO1 HSD17B7 ACAT2 TM7SF2 EBP PMVK SC5D LBR FDFT1 MYLIP FDPS HMGCS1 GGPS1 HMGCR ELOVL4 NR1H2 ELOVL3 NR1H3 CYP7A1 DHCR24 CH25H SCD MVD CYP46A1 ABCG1 CYP51A1 ROTENONE METABOLISM%WIKIPATHWAYS_20260710%WP5486%HOMO SAPIENS Rotenone metabolism CYP3A4 CYP2C19 IL2 SIGNALING%WIKIPATHWAYS_20260710%WP49%HOMO SAPIENS IL2 signaling RPS6KB2 GAB2 MAPK3 GRB2 FYN NMI LCK STAT1 RPS6KB1 RPS6 CISH HRAS PIK3R1 MAP2K1 STAT3 MAP2K2 CRKL SOS1 RAF1 PTK2B SYK SHC1 IL2RA IL2 IL2RB IL2RG CBL SOCS3 FOXO3A JAK1 JAK3 STAT5B MAPK1 PTPN11 INTERACTIONS BETWEEN LOXL4 AND OXIDATIVE STRESS PATHWAY%WIKIPATHWAYS_20260710%WP3670%HOMO SAPIENS Interactions between LOXL4 and oxidative stress pathway ECSIT FGF7 BMP2 DDR1 CDC37 EXOC6 IGFBP7 TGFB1 NQO1 NRF1 SUV39H1 PKD1 LOXL4 COL2A1 NFE2L2 SIRT1 HEL-S-7 HOST PATHOGEN INTERACTION OF HUMAN CORONAVIRUSES INTERFERON INDUCTION%WIKIPATHWAYS_20260710%WP4880%HOMO SAPIENS Host pathogen interaction of human coronaviruses interferon induction TYK2 NFKBIA OAS1 TBK1 IRF3 OAS2 STAT1 IRF9 RIPK1 TICAM1 IKBKE TRAF3 NFKB1 IFNAR2 MAPK8 CHUK EIF2AK2 IKBKB STAT2 TLR7 IKBKG IFNAR1 JUN IFIH1 FOS MAPK14 OAS3 MAVS MAP3K7 JAK1 TRAF6 MYD88 RIGI CELIAC DISEASE MECHANISM AND THERAPIES%WIKIPATHWAYS_20260710%WP5562%HOMO SAPIENS Celiac disease mechanism and therapies ITGA4 EGFR IL2 DHODH ITGB7 F2RL1 TNF IL-21 IFNG HEART DEVELOPMENT%WIKIPATHWAYS_20260710%WP1591%HOMO SAPIENS Heart development SHH FOXH1 VEGFA BMP4 FGF10 BMP2 MEF2C BMPR1A FOXC2 FOXC1 TBX20 SMYD1 NFATC2 IRX4 TBX5 TBX2 HAND2 SMAD4 FOXA2 TBX1 BMPR2 BMP10 GATA4 PITX2 ERBB3 NFATC3 NKX2-5 NFATC4 GATA6 VEGFB VEGFC HEY2 NOTCH1 BHLHB2 ISL1 HAND1 SMAD1 FGF8 NFATC1 MAPK1 PTPN11 KLEEFSTRA SYNDROME%WIKIPATHWAYS_20260710%WP5351%HOMO SAPIENS Kleefstra syndrome NR1I3 SMARCC1 PAXIP1 SMARCC2 H3F3B KMT2C ACTL6A RXRA MBD5 ACTL6B ARID1A ARID1B SMARCA4 SMARCD1 SMARCD2 PAGR1 SMARCD3 NCOA6 DPY30 EHMT1 ASH2L ASXL1 WDR5 BAP1 PHYSIOLOGICAL AND PATHOLOGICAL HYPERTROPHY OF THE HEART%WIKIPATHWAYS_20260710%WP1528%HOMO SAPIENS Physiological and pathological hypertrophy of the heart MYEF2 NFATC4 MAPK8 IL6ST PRKCB MAP2K3 CTF1 PRKCE JUN FOS MAPK14 RAC1 PPP3CA ARHA EDN1 MAPK11 CAMK2D GATA4 CALM1 STAT3 MAPK1 CYTOSOLIC DNA SENSING PATHWAY%WIKIPATHWAYS_20260710%WP4655%HOMO SAPIENS Cytosolic DNA sensing pathway NFKBIA TBK1 IRF3 POLR1C RIPK3 POLR1D TRADD CASP8 IFNA5 IFNA4 IFNA7 RIPK1 IFNA6 CCL4 FADD IFNA1 IFNA2 IKBKE IFNA8 DKFZp686F0183 IFNA21 IFNA13 IFNA14 TRIM25 IFNA16 IFNA17 IRF7 ATG12 CASP10 IFNA10 NFKBIB IL18 IL6 POLR2F CCL4L2 POLR2H POLR2K POLR3B POLR3D MITA IL33 RNF125 POLR3H IFNB1 POLR3K IL1B CGAS POLR2L ZBP1 AIM2 NFKB1 TREX1 CYLD ISG15 POLR3E PYCARD CHUK IKBKB IKBKG ADAR RELA POLR3GL NLRX1 MAVS POLR3A POLR3C POLR3F POLR3G CCL5 RIGI MRNA PROCESSING%WIKIPATHWAYS_20260710%WP411%HOMO SAPIENS mRNA processing WDR57 SFRS3 CLK4 LSM2 CLK2 CLK1 LSM7 SNRPB2 RNPS1 CLASRP HNRNPC DKFZp434N041 SUGP2 SUGP1 CELF1 CELF2 CELF4 DHX15 DHX16 RBM5 RBM17 PRMT2 NCBP1 NCBP2 PRPF40A PRPF18 NHP2L1 HNRNPH1 SNRPA1 DNAJC8 SF3B5 SF3B2 CSTF2T U2AF1 PABPN1 U2AF2 TRA2B SPOP SF3A1 SF3A2 HNRNPAB NUDT21 PHF5A HNRNPA2B1 RBMX POLR2A DICER1 TMED10 SRPK2 SMC1A METTL3 HNRNPL HNRNPD SRPK1 SFPQ CD2BP2 PTBP1 YBX1 SRP54 PPM1G SRSF10 SRSF9 PRMT1 HNRNPR SNRPD2 SNRPD1 RNMT CLP1 PAPOLA SNRPD3 TXNL4A PSKH1 PRP4K SNRPN CDC40 PRPF4 PRPF6 PRPF3 SNRPG SRSF4 SNRPE SNRPF SREK1 SRSF6 SRSF7 SUPT5H SNRPA SNRPB DHX8 DDX1 CSTF3 CSTF2 PRPF8 SFRS5 SFRS8 CSTF1 DHX38 CPSF4 CPSF1 FUS CPSF3 CPSF2 MICROTUBULE CYTOSKELETON REGULATION%WIKIPATHWAYS_20260710%WP2038%HOMO SAPIENS Microtubule cytoskeleton regulation MAP1B F2RL2 TRIO DVL1 CFL2 PRKCA AURKB GSK3B CLASP1 RAC1 PTEN WNT3A NTRK3 CAMK4 NTRK1 EPHB2 APC STAT3 NTRK2 CDC2 MAPKAPK2 SPRED1 PARD6A FREP1 LIMK1 TIAM1 MARK1 TAOK1 SRC MAPRE1 PHLDB2 ROCK1 RHO PAK1 CDC42 MET IN TYPE 1 PAPILLARY RENAL CELL CARCINOMA%WIKIPATHWAYS_20260710%WP4205%HOMO SAPIENS MET in type 1 papillary renal cell carcinoma VEGFA SOS2 MAPK3 GRB2 ELOA ARAF AKT3 KDR PLCG1 RAC1 BAD PIK3CD PIK3R3 HRAS PIK3R1 NRAS MAP2K1 STAT3 CDKN1A MAP2K2 CRKL MAPK8 RPL11 RAPGEF1 SOS1 RAF1 PIK3CA CRK JUN SRC PRCC PIK3R2 RAP1A INSL3 C8orf34 STRN PAK6 CBL ALK PAK1 JAK3 PAK4 HGF CDC42 MAPK1 PTPN11 FAMILIAL HYPERLIPIDEMIA TYPE 2%WIKIPATHWAYS_20260710%WP5109%HOMO SAPIENS Familial hyperlipidemia type 2 PCSK9 PLTP GPIHBP1 EPHX2 APOB USF1 APOA2 LPL APOA4 LDLR LIPC GHR TYPE II DIABETES MELLITUS%WIKIPATHWAYS_20260710%WP1584%HOMO SAPIENS Type II diabetes mellitus MAPK8 PIK3R5 IKBKB SLC2A4 TNF CACNA1A IRS1 MTOR SLC2A2 INSR PDX1 PHKA2 INS-IGF2 SURF1 SOCS4 MAFA PRKCZ MAPK1 MAPK SIGNALING AND ARTD FAMILY MEMBERS%WIKIPATHWAYS_20260710%WP5530%HOMO SAPIENS MAPK signaling and ARTD family members MAPK10 MAPK9 MAPK3 ARAF ATF4 TNKS MAP3K1 MAP2K1 MAP2K2 MAPK8 PARP14 MAP3K8 MAP3K5 MAP2K6 RAF1 MAP2K3 MAP3K10 MAP2K4 MAP3K11 MAP3K12 MAPK14 MAPK12 MAPK13 MAPK11 MAP3K7 MAP3K21 MAPK1 HORMONAL CONTROL OF PUBERTAL GROWTH SPURT%WIKIPATHWAYS_20260710%WP4194%HOMO SAPIENS Hormonal control of pubertal growth spurt GH1 GHRH SST IGF1 GNRH1 FLAVAN 3 OL METABOLIC PATHWAY%WIKIPATHWAYS_20260710%WP4238%HOMO SAPIENS Flavan 3 ol metabolic pathway LIPID PARTICLES COMPOSITION%WIKIPATHWAYS_20260710%WP3601%HOMO SAPIENS Lipid particles composition APOE APOB APOA2 LPL LDLR APOC3 APOC2 ULTRACONSERVED REGION 339 MODULATION OF TUMOR SUPPRESSOR MICRORNAS IN CANCER%WIKIPATHWAYS_20260710%WP4284%HOMO SAPIENS Ultraconserved region 339 modulation of tumor suppressor microRNAs in cancer CCNE2 CARNOSINE METABOLISM OF GLIAL CELLS%WIKIPATHWAYS_20260710%WP5313%HOMO SAPIENS Carnosine metabolism of glial cells SLC15A4 SLC15A2 CARNS1 CAFFEINE IN BLOOD VESSELS%WIKIPATHWAYS_20260710%WP5601%HOMO SAPIENS Caffeine in blood vessels GUCY1A2 PDE3B PDE3A PPP1R12C RYR2 RYR3 ADRA1B ADCY3 ADRA1A ADCY1 PDE4B PDE4A PDE4D ADCY8 ADCY6 ADCY5 ADCY9 MYLK ADORA2A HEL-S-80p ADORA2B ADRA1D CALM1 MIR TARGETED GENES IN MUSCLE CELL%WIKIPATHWAYS_20260710%WP2005%HOMO SAPIENS miR targeted genes in muscle cell YWHAQ PTPA MYO1E PPP3CA NCL HEL-S-273 NRP1 RFT1 GNPNAT1 SLC25A13 GFPT1 KIT CYP1B1 POLR2C TMED10 NF2 BACE1 POLD2 LAMC1 SEC23A PDLIM7 COL3A1 TNFRSF10B GSTM4 BACH1 PISD SLC12A2 RNP24 GPAM RAB27B HEL-S-108 TPM3 TPM1 LPL GRIA2 HYAL3 SDCBP CCNG1 CYR61 GALNT1 CSF1 PTPRF NELFCD MOV10 LAMC2 IGF2BP1 ARHG NOTCH1 C1QBP CYP51A1 DOCK5 ITGB4 ELMOD2 EHMT1 ASH2L TXN2 SNAP29 PRKCI FGF2 ERBB3 CDK6 ITGA2 USP1 RTN4 CSNK1D CDIPT MAPK7 NOTCH2 SSNA1 HES1 HEL-S-47e SLC25A1 FADS2 ANP32B DHX15 HEL-S-30 RQCD1 EIF4E VPS39 GPD2 TDG RDH10 SYNE1 PHLDB2 GNA13 STRN ABCG2 AXL NEDD4 SYNE2 SPTLC1 PDE3A TGFBR2 CPNE8 VEZT TMEM41B PWP1 CHORDC1 CPOX SLC38A1 THBS1 RAVER2 CIAO2A PSAT1 SEC62 CDK5RAP3 SFXN1 MBNL1 PPIF ATP6V0E1 HEL-S-303 IFRD1 FNDC3B CCND1 FNDC3A CARHSP1 WDR82 FAR1 TMEM87A HACD3 UBE2J1 MRPL20 COMMD9 GRPEL2 ATP6V1C1 SNX6 NCEH1 TRAM1 GFM1 MAGT1 MYLIP MRC2 PANX1 COIL SERP1 ERG TMED3 HEL-S-66 CTSC MRPS24 TMT1A AP3B1 SLC7A6 ARID1A CDCP1 RHEB ACVR1B VSNL1 ATP2A2 CSDE1 GJA1 FRG1 PXDN AMIGO2 FSTL1 NAPG PGRMC1 PPP1R7 EZH2 MPZL1 CACNA2D1 CA12 SPRYD4 TTC9C ARCN1 WDR11 TPPP3 ARF4 NFIA SNX15 HMOX1 LAMTOR3 DSG2 COL1A1 LAMTOR5 COL1A2 TUSC2 LTN1 SLC38A5 ARID4B ABHD10 POGLUT3 SH3BGRL3 PKN2 KPNA3 RARS1 STX7 UBE4A CDKAL1 RAB30 SYPL1 GEMIN7 PPIB RAI14 PTMA SHOC2 CBFB POLA2 SLC1A4 ADIPOR2 CORO1C ANAPC1 CAMTA1 CD164 BRPF3 HMGA1 SLC4A10 GNL3L CHMP2A SRPRB DKFZp761E1322 RB1 SNAP23 CEBPB DOCK7 CDKN1A TNFAIP2 EGFR LMNB2 TMEM109 PLK1 ACP2 SCYL1 HSDL1 RCN2 RBMS1 LUZP1 NUFIP2 MCL1 NXN UHRF1 HSD17B12 DNAJB1 CAND1 CDKN1B TP53INP1 IRS1 SH3BP4 TBCA ZNF622 SLC25A24 GALNT7 MAPK14 SLC4A7 MAPK12 FMNL2 SLC25A32 BET1 E2F3 NT5E BCL2 POLE4 IGF2R ERBB2 TMEM43 P4HA2 SRSF10 PICALM SRSF9 CUL4B TMED7 CALCOCO2 CXCL12 MTRR AP3D1 ATG9A SPCS3 ADAR TYMS SPARC MTHFD2 CLDN1 SLC7A11 MFAP5 EFFECT ON PERMEABILITY AND MOTILITY OF ENDOTHELIAL CELLS VIA CYTOSKELETON REARRANGEMENT%WIKIPATHWAYS_20260710%WP4560%HOMO SAPIENS MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement CREB1 MAPK3 ITGB3 HEL114 JUN TJP1 PXN MYLK PRKCQ PLCG1 ACTN1 LPP MFAP5 ITGAV MYL2 MAPK1 T CELL MODULATION AND DESMOPLASIA IN PANCREATIC CANCER%WIKIPATHWAYS_20260710%WP5078%HOMO SAPIENS T cell modulation and desmoplasia in pancreatic cancer SHH VEGFA PDCD1LG2 PDCD1 TNFRSF4 CCL22 CXCR4 TNLG5A TNLG2B CD40LG CD226 CD40 TNFRSF9 IDO1 LGALS9 ARG1 ICOS NR1i1 HLA-A HAVCR2 IL13 VEGFB ENTPD1 VEGFC VEGFD CXCL12 IL10 IL4 TGFB1 CD80 CTLA4 PDGFD PDGFC TIGIT VTCN1 VSIR IL6 PDGFA CCL17 TNFSF6 B2M FAP NT5E ALANINE AND ASPARTATE METABOLISM%WIKIPATHWAYS_20260710%WP106%HOMO SAPIENS Alanine and aspartate metabolism ABAT GPT ASS1 AGXT PC ASL GOT2 GAD1 GAD2 ASPA RETINOID METABOLISM IN RETINA HEALTHY VS RLBP1 DEFICIENT%WIKIPATHWAYS_20260710%WP5532%HOMO SAPIENS Retinoid metabolism in retina healthy vs RLBP1 deficient RLBP1 PILOCYTIC ASTROCYTOMA%WIKIPATHWAYS_20260710%WP2253%HOMO SAPIENS Pilocytic astrocytoma GRB2 SOS1 RAF1 HRAS NRAS NF1 PTPN11 DISORDERS OF BILE ACID SYNTHESIS AND BILIARY TRANSPORT%WIKIPATHWAYS_20260710%WP5176%HOMO SAPIENS Disorders of bile acid synthesis and biliary transport HSD3B7 ATP8B1 ABCB4 SLC51A CYP27A1 SLC51B AMACR SLC27A2 SLC27A5 ABCB1 SLC10A2 AKR1D1 ABCB11 SLCO1B1 CYP7A1 FABP6 HSD17B4 BAAT CYP7B1 AKR1C4 ABCC3 ABCD3 CYP8B1 ABCC2 NANOMATERIAL INDUCED INFLAMMASOME ACTIVATION%WIKIPATHWAYS_20260710%WP3890%HOMO SAPIENS Nanomaterial induced inflammasome activation PYCARD IL1B NFKB1 TLR4 THERMOGENESIS%WIKIPATHWAYS_20260710%WP4321%HOMO SAPIENS Thermogenesis RPS6KB2 CNR1 CPT1A GRB2 CPT2 PS1TP5BP1 ACSL1 MLST8 FACL4 ACSL3 SLC25A20 AKT1S1 MTOR ADCY9 RPS6KB1 PRKACG ATF2 ADRB3 LIPE KDM1A MAP3K5 ADCY3 ADCY1 GCG MAP2K3 PRKG1 ADCY8 ADCY6 ADCY5 SIRT6 HEL-S-7a FRS2 MAPK14 FGFR1 ZNF516 BMP8B MAPK12 MGLL KDM3B MAPK13 MAPK11 SOS2 DPF1 DPF3 ACTL6A CPT1C KDM3A SLC25A29 SMARCE1 ACTL6B BMP8A RPS6KA1 ACSL6 PPARGC1A ACSL5 SMARCA4 RPTOR TSC2 CREB3 CREB3L3 CREB3L4 PRKAA1 CREB3L2 PRKAA2 CREB5 PRKAG1 RPS6 PRKAG2 TSC1 PRDM16 UCP1 HRAS PRKAG3 PPARG NRAS FGF21 CREB1 PRKAB2 SMARCC1 RPS6KA6 SMARCC2 RPS6KA2 PNPLA2 PRKAB1 GNAS SOS1 ARID1A RHEB ARID1B SMARCD1 SMARCD2 SMARCD3 PLIN1 ACTG1 GENES CONTROLLING NEPHROGENESIS%WIKIPATHWAYS_20260710%WP4823%HOMO SAPIENS Genes controlling nephrogenesis SHH PAX2 VEGFA EYA1 CD2AP LHX1 CXCR4 NCK2 GDNF LMX1B FOXC2 FOXC1 NCK1 ROBO2 WNT4 LAMB2 NPHS1 NPHS2 CD36 WT1 KDR HEL-S-28 FGFR2 CXCL12 TCF21 ETV4 SLIT2 EMX2 FOXD1 ITGB1 TCF2 RET NOTCH2 SIX1 HOXD11 GLI3 FGF8 HOXA11 MAFB BEMPEDOIC ACID THERAPY IN ATHEROSCLEROSIS AND METABOLIC SYNDROME%WIKIPATHWAYS_20260710%WP5500%HOMO SAPIENS Bempedoic acid therapy in atherosclerosis and metabolic syndrome MAPK10 MAPK9 PCK2 SLC27A2 MAPK3 G6PC1 ACACB CRP PRKAA1 PRKAA2 ACLY PRKAG1 G6PC2 HMGA1 PRKAG2 G6PC3 PRKAG3 MAPK8 PRKAB2 PRKAB1 MAPK14 MAPK12 ACACA MAPK13 MAPK11 MAPK1 FIBROTIC RESPONSE OF TRABECULAR MESHWORK CELLS TO TGFB3 AND ENPP2 IN AQUEOUS HUMOR%WIKIPATHWAYS_20260710%WP5545%HOMO SAPIENS Fibrotic response of trabecular meshwork cells to TGFB3 and ENPP2 in aqueous humor MAPK10 COL1A1 MAPK8 LPA ACTA2 MAPK9 RHO CTGF ENPP2 TGFB1 STAT3 ARACHIDONIC ACID AA ARA OXYLIPIN METABOLISM%WIKIPATHWAYS_20260710%WP5155%HOMO SAPIENS Arachidonic acid AA ARA oxylipin metabolism EPHX2 PTGS2 PTGS1 DUAL HIJACK MODEL OF VIF IN HIV INFECTION%WIKIPATHWAYS_20260710%WP3300%HOMO SAPIENS Dual hijack model of Vif in HIV infection CBFB UBB ELOC RUNX1 APOBEC3G CUL5 RBX1 TGF BETA RECEPTOR SIGNALING%WIKIPATHWAYS_20260710%WP560%HOMO SAPIENS TGF beta receptor signaling MAPK3 STAT3 CREBBP DKFZp781O1323 RUNX2 JUN FOS ZFYVE9 SMAD1 JAK1 SMAD9 TGIF1 LEFTY1 IFNG FST NOG FOXH1 opn LEF1 BMP4 RUNX3 TGFBR1 TGFBR2 MAPK9 TGFBR3 ZEB2 ENG LTBP1 THBS1 WNT1 ZNF423 TNF SKIL LEFTY2 SMAD2 EGF STAT1 SMAD4 LIF INHBA SMAD6 EP300 FKBP1A SKI BAMBI NFKB1 ITGB6 HRAS TGFB1 GENES AND COMPLEXES INVOLVED IN THE DNA REPAIR PATHWAYS%WIKIPATHWAYS_20260710%WP4946%HOMO SAPIENS Genes and complexes involved in the DNA repair pathways APEX1 CHEK1 MSH2 PRKDC XRCC5 BRCA1 ATR TDG CCNH CETN2 XPA SMUG1 XPC HMGB1 POLE GTF2H2C_2 RFC3 RFC4 LIG1 RFC1 RFC2 PARP2 GTF2H2 GTF2H3 WRN GTF2H4 POLM GTF2H5 POLL DDB2 RBX1 NHEJ1 CUL4A DDB1 POLK POLE4 CDK7 POLE2 RPA3 ERCC1 POLE3 ERCC2 ERCC5 MNAT1 RAD52 CUL4B POLD3 POLD4 RAD50 RAD51 FEN1 POLD2 MPG RPA1 OGG1 MRE11A REV3L NBN BRCA2 POLI REV1 RAD54B NEIL3 NEIL2 RAD51C MSH3 PNKP FAAP24 MSH6 UNG BRIP1 NTHL1 PMS2 WDR48 MUTYH FANCD2 MBD4 FANCM ATM PCNA CENPX FAN1 FANCL FANCA APEX2 FANCB USP1 FANCE PALB2 FANCG TERF2 FANCF CENPS H2AX RAP1A BIOSYNTHESIS AND TURNOVER OF 1 DEOXY SPHINGOID BASES%WIKIPATHWAYS_20260710%WP5179%HOMO SAPIENS Biosynthesis and turnover of 1 deoxy sphingoid bases KDSR SPTLC1 SPTLC2 SPHK2 SPHK1 SGPP1 SGPP2 HIPPO MERLIN SIGNALING DYSREGULATION%WIKIPATHWAYS_20260710%WP4541%HOMO SAPIENS Hippo Merlin signaling dysregulation NGFR PPP1R14A CTNNA1 AMOT PLCB4 PRKACG NTRK1 EGFR IGF1R FLT4 CDH9 CDH8 CDH6 CDH4 TEAD2 TEAD3 TEAD4 PDGFRA LATS1 LATS2 PRKAR1B PRKAR1A CDH10 FGFR1 CDH11 KIT CDH12 CDH15 MYC CDH16 CDH17 CDH19 EPHA2 YAP1 RBX1 CDH24 WWTR1 CUL4A DDB1 AJUBA NF2 FGFR3 ITGB3 ITGAM ITGB4 ITGA2B CSF1R ITGAE CCND1 PPP1CC KDR ITGAX HEL-S-80p CDH18 ITGB8 INSR ITGAV ITGB7 ITGB6 HRAS NRAS ITGA4 NTRK2 ITGA2 FGFR4 ITGA1 FGFR2 FLT3 ITGA7 ITGA6 FOXM1 DCAF1 VGLL4 LIN28B ITGB1 CDH2 FLT1 PAK6 CTGF CD44 PAK1 PAK4 STEROID BIOSYNTHESIS%WIKIPATHWAYS_20260710%WP496%HOMO SAPIENS Steroid biosynthesis HSD17B3 HSD17B4 HSD17B1 CPN1 HSD17B2 HSD3B1 HSD3B2 HSD17B7 F13B CYP17A1 GLYCEROL METABOLISM INCLUDING LINKED IMDS%WIKIPATHWAYS_20260710%WP5570%HOMO SAPIENS Glycerol metabolism including linked IMDs HEL-S-165mP GLYCTK PGAM1 G6PC1 KHK LIPE HEL-S-68p GPD2 PNPLA2 HEL-S-49 PFKL AQP7 PC ALDOB FBP1 AQP9 HEL-S-87p ENO1 GPD1 MGLL AGXT PCK1 PKLR HEL-S-162eP FAMILIAL HYPERLIPIDEMIA TYPE 3%WIKIPATHWAYS_20260710%WP5110%HOMO SAPIENS Familial hyperlipidemia type 3 PLTP VLDLR APOE APOA2 LPL APOA4 LDLR SCARB1 LIPC DNA MISMATCH REPAIR%WIKIPATHWAYS_20260710%WP531%HOMO SAPIENS DNA mismatch repair POLE4 PCNA POLE2 RPA3 POLE3 POLD3 POLD4 POLD2 RPA1 MSH2 POLE RFC3 RFC4 LIG1 RFC1 RFC2 MSH6 PMS2 3Q29 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260710%WP4906%HOMO SAPIENS 3q29 copy number variation syndrome CEP350 MCRS1 DYNC2I2 MAD2L1BP WDR53 RABL2B ZNF76 NCBP1 NCBP2 DNCL1 TF JUN FBXW7 ADAM10 MYC STAT5B DYNLRB2 SLC51A NF2 SLC51B HFE TFRC HEL-S-71 SLC40A1 PIK3R3 HAMP NRROS DYNLT1 SIRT1 DYNLT3 DYNLL2 TGFB1 PIGX PXN UBXN7 SMCO1 DYNC2H1 HIF1A FNDC8 RNF168 PIGM MFI2 CEP19 H2BC21 MYCBP2 RNF8 FBXO45 DYNLT2B DYNC2LI1 ZDHHC19 BRINP1 TM4SF19 LINOLEIC ACID METABOLISM AFFECTED BY SARS COV 2%WIKIPATHWAYS_20260710%WP4853%HOMO SAPIENS Linoleic acid metabolism affected by SARS CoV 2 ACE2 ELOVL5 ELOVL2 FADS2 FADS1 GALANIN RECEPTOR PATHWAY%WIKIPATHWAYS_20260710%WP4970%HOMO SAPIENS Galanin receptor pathway CDKN1A VEGFA CREB1 BCL2L11 CDKN1C SLC2A4 POMC CDKN1B VAMP2 CRP FOS INS IL6 YAP1 PPARG CARDIOMYOCYTE SIGNALING CONVERGING ON TITIN%WIKIPATHWAYS_20260710%WP5344%HOMO SAPIENS Cardiomyocyte signaling converging on titin GUCY1B1 FHL1 TTN CSRP3 ANKRD1 ANKRD2 HEL-S-101 ANKRD23 NBR1 C22orf13 PRKCA TCAP MYPN TRIM55 PRKACG TRIM63 CAMK2A MAP2K1 NUP62 MAP2K2 MDM2 RAF1 PRKAR1A FHL2 ADRB1 ADRB2 MAPK1 SOMITOGENESIS IN THE CONTEXT OF SPONDYLOCOSTAL DYSOSTOSIS%WIKIPATHWAYS_20260710%WP4785%HOMO SAPIENS Somitogenesis in the context of spondylocostal dysostosis MESP2 EPHA4 DLL3 RIPPLY2 TBX6 LFNG HES7 NOTCH1 SENESCENCE AND AUTOPHAGY IN CANCER%WIKIPATHWAYS_20260710%WP615%HOMO SAPIENS Senescence and autophagy in cancer COL1A1 COL10A1 MLST8 VTN AKT1S1 ING1 MTOR SLC39A2 SLC39A1 CDC25B SLC39A3 SH3GLB1 SERPINB2 RNASEL IL24 IFI16 CCL3 IGFBP5 CREG1 HMGA1 UVRAG RSL1D1 RB1 DKFZp686F0183 CEBPB CDKN1A RB1CC1 LAMP2 IGF1R PLAT ATG3 IL1A ATG10 IRF7 ATG12 MMP14 MAP2K3 IGFBP7 CDKN1B JUN CDKN2A AMBRA1 BMI1 MAPK14 IL6 IFNG IGF1 IRF-1 BCL2 CXCL14 GABARAPL2 IL6R GABARAPL1 IL3 ATG14 GABARAP BMP2 IL6ST ATG16L1 IFNB1 THBS1 MAP1LC3A SMAD4 INHBA GSK3B PTEN IL1B COL3A1 CXCL8 INS HRAS CXCL1 MAP1LC3C MAP2K1 TNLG1B MDM2 PCNA DKFZp762B153 KMT2A ULK1 RAF1 SQSTM1 TGFB1 SRC SPARC CD44 MAPK1 DDX1 AS A REGULATORY COMPONENT OF THE DROSHA MICROPROCESSOR%WIKIPATHWAYS_20260710%WP2942%HOMO SAPIENS DDX1 as a regulatory component of the Drosha microprocessor MRE11A ATM DGCR8 NBN DDX1 DROSHA RAD50 LTF DANGER SIGNAL RESPONSE PATHWAY%WIKIPATHWAYS_20260710%WP4478%HOMO SAPIENS LTF danger signal response pathway AGER IRAK4 IL1A IFNB1 CD14 TNF IRAK1 IFNA1 IL1B NFKB1 CXCL8 HEL110 IL6 TRAF6 MYD88 TREM1 MAPK1 TLR4 ACUTE VIRAL MYOCARDITIS%WIKIPATHWAYS_20260710%WP4298%HOMO SAPIENS Acute viral myocarditis MYH6 AIF1 MAPK3 PS1TP5BP1 DMD FYN CASP9 CASP8 CASP3 CYCS AAG1 EDN1 CAAP1 CXADR TLR5 NOD2 TLR4 CHRAC1 STAT3 BNIP2 CASP6 DFFB DFFA EIF4G1 HLA-DMA IL2 CCR5 SOCS1 MICA JAK1 IL6 IFNG BCL2 BAX BCL2L1 CXCR4 PABPC1 TNF CD40LG STAT1 CCND1 GSK3B CCR3 TICAM1 RAC3 NFKB2 PIK3R1 CASP2 IL12B CREB1 PYCARD HEL-S-28 IL10 SOS1 TLR3 CD55 TGFB1 CD80 SGCD IL12A SRC SGCA SGCB SGCG DAG1 ABL2 MMP9 MAPK1 CELL DIFFERENTIATION INDEX%WIKIPATHWAYS_20260710%WP2029%HOMO SAPIENS Cell differentiation index TLX3 TLX2 HDAC5 TLX1 LEFTY2 LEFTY1 STAT3 DISRUPTION OF POSTSYNAPTIC SIGNALING BY CNV%WIKIPATHWAYS_20260710%WP4875%HOMO SAPIENS Disruption of postsynaptic signaling by CNV MAPK3 NLGN1 CYFIP1 STX1A CAMK2D FMR1 CAMK2A DLGAP1 NRXN3 SYNGAP1 NLGN3 NLGN2 CAMK2G NRXN2 HOMER1 DLG2 GRIN2B RYR2 RPH3A GRIN1 ARC NRXN1 YWHAG TJP1 SHANK1 MAPK1 FOXP3 IN COVID 19%WIKIPATHWAYS_20260710%WP5063%HOMO SAPIENS FOXP3 in COVID 19 IL6R IL2RA FOXP3 IL2RB IL6ST IL2 IL2RG IL6 IL7R STAT5B CD80 STAT3 GIP AND GLP 1 FUNCTION BY TISSUE%WIKIPATHWAYS_20260710%WP5509%HOMO SAPIENS GIP and GLP 1 function by tissue GIP GCG TCA CYCLE AKA KREBS OR CITRIC ACID CYCLE %WIKIPATHWAYS_20260710%WP78%HOMO SAPIENS TCA cycle aka Krebs or citric acid cycle FH SUCLA2 OGDH IDH3B SUCLG1 SDHB SUCLG2 DLD SDHA ACO2 CS SDHC SDHD MDH2 LUNG PATHOLOGY OF COVID 19%WIKIPATHWAYS_20260710%WP5146%HOMO SAPIENS Lung pathology of COVID 19 CXCL9 MITA TBK1 TLR7 TLR8 TNF IRF3 TLR3 CSF2 IFIH1 CXCL11 IL1B CGAS MAVS NFKB1 IL18 IL6 CCL2 RIGI MEVALONATE ARM OF CHOLESTEROL BIOSYNTHESIS PATHWAY WITH INHIBITORS%WIKIPATHWAYS_20260710%WP4189%HOMO SAPIENS Mevalonate arm of cholesterol biosynthesis pathway with inhibitors MVD HMGCR MYOMETRIAL RELAXATION AND CONTRACTION PATHWAYS%WIKIPATHWAYS_20260710%WP289%HOMO SAPIENS Myometrial relaxation and contraction pathways YWHAQ PS1TP5BP1 PRKCA ATF4 IGFBP5 CAMK2D PRKD1 LPAR1 ADCY3 CRCP ADCY1 RXFP2 IGFBP4 ADCY8 PRKCE CNN2 MYL4 CALD1 ADCY6 IGFBP6 PRKAR1B RLN1 ADCY5 ADM PRKAR1A RAMP2 PRKCQ RAMP3 CORIN GUCA2B GUCA2A ACKR5 RGS14 PDE4B PDE4D CREB3 PLCG1 RGS16 HEL-S-14 RAMP1 ATF1 CREB1 OXTR RYR1 ATF5 RYR2 RYR3 GABPB1 ETS2 GABPA ATP2A2 SLC8A1 GJA1 ACTA2 GNG12 GNG11 ACTA1 GNG13 ACKR3 MYL2 MAFF CACNB3 RGS4 RGS5 RGS2 RGS1 HEL2 RGS6 DKFZp686L0365 CRH PRKCB ITPR2 GRK5 HEL-S-21 GRK4 PLCB3 PKIB ADCY9 PKIA PKIG GNB2 CALM1 GNB4 RGS18 ATF2 GNB3 RGS17 CAMK2A GNB5 SFN RGS20 CAMK2G RGS11 ATF6B CALCA HEL-S-1 YWHAG JUN GNG3 GNG2 GNG5 GNG4 FOS GNG7 GNG8 IL6 MYLK2 RGS10 IGFBP1 IGFBP2 IL1B PRKCH NFKB1 OXT PRKCZ PLCG2 GNGT1 SP1 GNB1 GNAS HEL-S-93 ATF3 DGKZ ACTG1 MRNA PROTEIN AND METABOLITE INDUCED STRESS PATHWAY BY CYCLOSPORIN A%WIKIPATHWAYS_20260710%WP3953%HOMO SAPIENS mRNA protein and metabolite induced stress pathway by cyclosporin A SLC7A5 SLC3A2 KEAP1 NFE2L2 SLC7A11 ATF4 CLASSICAL PATHWAY OF STEROIDOGENESIS WITH GLUCOCORTICOID AND MINERALOCORTICOID METABOLISM%WIKIPATHWAYS_20260710%WP4523%HOMO SAPIENS Classical pathway of steroidogenesis with glucocorticoid and mineralocorticoid metabolism POR STAR HSD3B2 CYP17A1 CYP11B2 HSD17B3 CYP11A1 HSD3B1 H6PD SRD5A2 HSD11B1 HSD11B2 CYP21A2 SUZETRIGINE MECHANISM FOR PAIN RELIEF%WIKIPATHWAYS_20260710%WP5558%HOMO SAPIENS Suzetrigine mechanism for pain relief SCN10A IL3 SIGNALING%WIKIPATHWAYS_20260710%WP286%HOMO SAPIENS IL3 signaling BCL2 IL5RA GAB2 BCL2L1 IL3 YWHAQ MAPK3 GRB2 FYN CSF2RB INPP5D CCR3 BAD PIK3CD CXCL8 HRAS PIK3R1 MAP2K1 STAT3 CRKL MAPK8 ENPP3 IL3RA RAPGEF1 HEL-S-1 SOS1 RAF1 TGFB1 SYK JUN SHC1 SRC VAV1 PIK3R2 FOS PTPN6 CBL LYN JAK1 CD69 STAT5B MAPK1 PTPN11 VITAMIN B6 DEPENDENT AND RESPONSIVE DISORDERS%WIKIPATHWAYS_20260710%WP4228%HOMO SAPIENS Vitamin B6 dependent and responsive disorders ALPI HEL-S-1a PIGV ALPL ALDH7A1 HEL-S-302 PLPBP AMP ACTIVATED PROTEIN KINASE SIGNALING%WIKIPATHWAYS_20260710%WP1403%HOMO SAPIENS AMP activated protein kinase signaling RPS6KB2 CPT1A MTOR ADIPOR2 RPS6KB1 PRKACG PLCB1 FASN STRADA CAB39 ELAVL1 CDKN1A STRADB LIPE STK11 EEF2 EEF2K CCNA2 INS-IGF2 HNF4A LEPR ADIPOR1 SLC2A4RG CRTC2 CPT1C LEP SLC2A4 RPTOR TSC2 ACACB PRKAA1 PRKAA2 PRKAG1 PIK3CD INSR PIK3R3 PRKAG2 TSC1 PIK3R1 PRKAG3 PPARGC1B EIF4EBP1 PRKAB2 CAMKK1 HMGCR PRKAB1 ADRA1B ADRA1A PIK3CA CCNB1 GYS1 PIK3R2 ACACA CAMKK2 GYS2 TGF BETA SIGNALING IN THYROID CELLS FOR EPITHELIAL MESENCHYMAL TRANSITION%WIKIPATHWAYS_20260710%WP3859%HOMO SAPIENS TGF beta signaling in thyroid cells for epithelial mesenchymal transition SNAI1 MAPK3 ID1 SNAI2 RUNX2 CDH6 SMAD2 SMAD4 HEL113 TNC AKT3 CDH2 CDH16 MAPK1 VASOPRESSIN REGULATED WATER REABSORPTION%WIKIPATHWAYS_20260710%WP5085%HOMO SAPIENS Vasopressin regulated water reabsorption AQP2 AQP3 STX4A DCTN6 DYNC1I1 DYNC1H1 DCTN5 DYNC1LI2 AVP DCTN1 DCTN4 ARHGDIB HEL-S-77 RAB11A RAB5A RAB11B VAMP2 DYNC1LI1 CREB3 CREB3L3 ADCY9 CREB3L4 CREB3L2 PRKACG CREB5 DNCL1 CREB1 DYNLL2 ARHGDIG GNAS ADCY3 AQP4 ADCY6 AVPR2 DYNC2H1 RAB5B RAB5C DYNC2LI1 HEL-S-47e BASE EXCISION REPAIR%WIKIPATHWAYS_20260710%WP4752%HOMO SAPIENS Base excision repair POLE4 POLE2 POLE3 APEX1 ADPRHL2 POLD3 APTX POLD4 POLG2 TDP1 NEIL1 FEN1 POLD2 MPG OGG1 POLG NEIL3 NEIL2 PARP4 PNKP UNG NTHL1 MUTYH MBD4 PCNA PARP3 TDG SMUG1 HMGB1 POLE RFC3 RFC4 LIG1 RFC1 RFC2 PARP2 POLL GASTRIC CANCER NETWORK 2%WIKIPATHWAYS_20260710%WP2363%HOMO SAPIENS Gastric cancer network 2 TOP2A UBE2C DSCC1 OTUD5 CHTF18 MTDH CHTF8 BRIX1 ATAD2 CACYBP FAM91A1 RNF144B UBE2T S100A6 AHCTF1 RAD17 CD48 CEBPZ LBR EGFR LMNB2 SNURF DGIC RFC3 RFC4 COL9A1 MYC COL9A3 HISTONE MODIFICATIONS%WIKIPATHWAYS_20260710%WP2369%HOMO SAPIENS Histone modifications AEBP2 SMYD1 SET EHMT1 H3C15 KMT2E SETD4 SETD5 SETD3 SETD8 SMYD5 SETD9 SETD6 H4C9 KMT2B DOT1L KMT2C PRDM2 H3F3B SMYD2 HIST1H4L KMT5B KMT2A SMYD4 SMYD3 H4C7 SETDB1 KMT5C SETD1B SETD1A EED SETDB2 SETMAR ASH1L SETBP1 MLL2 EZH1 SETD2 EZH2 SUV39H2 SUV39H1 SETD7 H3C8 GLYCOSYLPHOSPHATIDYL INOSITOL ANCHOR PATHWAY%WIKIPATHWAYS_20260710%WP5505%HOMO SAPIENS Glycosylphosphatidyl inositol anchor pathway PIGB PIGA PIGV PIGK MPPE1 PIGL PIGF PIGH DPM2 PIGX PIGS PIGU PIGT PGAP1 PIGO PGAP2 PIGM PIGN GPAA1 PGAP3 PIGP PIGW PIGY PIGC DIRECT REVERSAL REPAIR%WIKIPATHWAYS_20260710%WP4931%HOMO SAPIENS Direct reversal repair ALKBH2 ALKBH3 OLIGODENDROCYTE DEVELOPMENT%WIKIPATHWAYS_20260710%WP5574%HOMO SAPIENS Oligodendrocyte development SHH RELN BMP4 ZEB2 EGR2 CHD8 PTN ZNF24 DUSP15 NKX6-1 NFATC2 ZNF488 PRKCA LGI1 TCF7L2 WNT10A OPALIN ZBTB33 SOX8 CNTN1 NKX2-2 NKX2-6 GIG8 SOX11 SOX2 FGF2 BMP1 MYT1 SOX9 SOX6 SOX5 PDGFRA OLIG1 ID4 MYRF CSPG4 OLIG2 ASCL1 SMAD1 SOX10 TMEM98 MBP HES5 NFIA NRF2 PATHWAY%WIKIPATHWAYS_20260710%WP2884%HOMO SAPIENS NRF2 pathway AGER SLC39A2 SLC2A2 SLC39A1 SLC39A3 SLC2A3 PTGR1 SLC6A19 CYP4A11 ADH7 NR1C2 ME1 CES2 CES1 EPHA2 TGFBR2 MGST3 KEAP1 GSTT2 FTL MGST2 SLC2A4 GSTM4 GSTM3 GSTM2 FTH1 SLC39A8 GSTM1 SLC39A14 TGFA SQSTM1 GSTM5 SLC6A13 SLC6A11 HEL-S-128m MAFF HGF HMOX1 SLC5A1 SLC6A8 GPX2 SLC2A14 UGT1A1 GPX3 SLC39A9 SLC39A6 SLC39A5 HEL-S-22 SLC6A18 SLC6A17 SLC6A16 HEL126 ALDH3A1 HEL-75 SLC5A8 SLC5A9 NRG1 CYP2A6 CES8 EGR1 GCLC CES3 GCLM NFE2L2 EPHA3 SLC5A2 SLC6A20 SLC5A3 FGF13 SLC5A4 SLC2A9 HSP90AB1 UGT2B7 SLC6A5 SLC6A7 SLC6A9 SLC2A6 SLC2A7 SLC2A8 SLC2A11 SLC2A10 SLC2A13 HEL-S-25 DNAJB1 SLC39A11 SLC39A10 SLC39A13 UGT1A4 SLC39A12 UGT1A3 SMVT UGT1A9 SLC5A12 SLC5A10 UGT1A7 SLC5A5 SRXN1 SLC2A12 HBEGF GSTA5 GSTA4 GSTA3 MAFG SLC6A2 SLC6A3 SLC5A7 NQO1 ABCC5 SERPINA1 ABCC3 TXN ABCC2 HEL-S-10 RXRA TGFB1 SLC7A11 METASTATIC BRAIN TUMOR%WIKIPATHWAYS_20260710%WP2249%HOMO SAPIENS Metastatic brain tumor CDK6 MYC E2F3 PIK3R1 CDC42 BMP SIGNALING IN EYELID DEVELOPMENT%WIKIPATHWAYS_20260710%WP3927%HOMO SAPIENS BMP signaling in eyelid development SHH EGFR DKK2 BMP4 DKFZp781O1323 FGF10 MAPK9 FGFR2 MAPK3 FOXC2 FOXC1 TGFA NOTCH1 JUN SMAD4 MAP3K1 SFRP1 INHBB SMAD1 PITX2 CATABOLISM OF SKELETAL MUSCLE IN CACHEXIA%WIKIPATHWAYS_20260710%WP5474%HOMO SAPIENS Catabolism of skeletal muscle in cachexia NFKBIA IL6R TNFSF12 MLST8 TNF SMAD2 AKT1S1 IL1R1 RPTOR MTOR MAP1LC3A SMAD4 FBXO32 MSTN EP300 TRIM63 IL1B NFKB1 NFKB2 CEBPB TNFRSF12A STAT3 CHUK IGF1R IKBKB IL1A IKBKG ACVR2A RELA TNFRSF1A RELB FOXO3A MAPK11 JAK1 IL6 REL IGF1 NEOLACTO SERIES SPHINGOLIPID METABOLISM%WIKIPATHWAYS_20260710%WP5302%HOMO SAPIENS Neolacto series sphingolipid metabolism FUT5 B4GALT1 FUCA1 FUT1 NAGA SIAT4C NEU2 B4GALT4 hCG_1998026 B3GNT5 GLP 1 SECRETION FROM INTESTINE TO PORTAL VEIN%WIKIPATHWAYS_20260710%WP5446%HOMO SAPIENS GLP 1 secretion from intestine to portal vein SLC2A2 SLC5A1 PCSK1 GCG ETHER LIPID BIOSYNTHESIS%WIKIPATHWAYS_20260710%WP5275%HOMO SAPIENS Ether lipid biosynthesis ACAD10 ALDH3A2 LPIN1 UGT8 CEPT1 PEX16 GNPAT FAR1 PEX19 LPIN2 LPCAT1 PEDS1 LPIN3 PEX7 PEX5L PEX3 DHRS7B AGMO WNT SIGNALING IN ADULT HIPPOCAMPAL NEUROGENESIS%WIKIPATHWAYS_20260710%WP5536%HOMO SAPIENS Wnt signaling in adult hippocampal neurogenesis FZD1 NEUROG2 CCND1 PROX1 WNT3A WNT7A WNT3 LRP6 NEUROD1 FZD3 LEUCINE ISOLEUCINE AND VALINE METABOLISM%WIKIPATHWAYS_20260710%WP4686%HOMO SAPIENS Leucine isoleucine and valine metabolism ACAD8 ACSF3 DBT IVD MLYCD HSD17B10 ACADSB ACAT1 MCCC2 DLD PCCA MCCC1 PCCB ECHS1 BCAT2 BCAT1 NANOPARTICLE TRIGGERED REGULATED NECROSIS%WIKIPATHWAYS_20260710%WP2513%HOMO SAPIENS Nanoparticle triggered regulated necrosis TRADD MAPK8 CASP8 RIPK1 TICAM1 FADD TNFRSF1A FTL TNF RIPK3 DEVELOPMENT AND HETEROGENEITY OF THE ILC FAMILY%WIKIPATHWAYS_20260710%WP3893%HOMO SAPIENS Development and heterogeneity of the ILC family RORC TSLP IL33 GFI1 ATL1-beta TNF RORA AREG NFIL3 HNF1A GIG8 ZBTB16 IL1B AHR IL25 IL12B IL13 TOX GATA3 IL22 IL23A IL4 IL5 IL17A IL12A TBX21 IL18 IL6 IL7 IFNG IL9 VEDOLIZUMAB THERAPY FOR INFLAMMATORY BOWEL DISEASE%WIKIPATHWAYS_20260710%WP5512%HOMO SAPIENS Vedolizumab therapy for inflammatory bowel disease ITGA4 ITGB1 ITGA2 VCAM1 MADCAM1 SELPLG ITGB7 SELE INSULIN SIGNALING IN ADIPOCYTES NORMAL CONDITION %WIKIPATHWAYS_20260710%WP3634%HOMO SAPIENS Insulin signaling in adipocytes normal condition IRS1 MTOR RPS6KB1 TBC1D4 INSR RPS6 SLC2A4 MFAP5 MEDIATED OVARIAN CANCER CELL MOTILITY AND INVASIVENESS%WIKIPATHWAYS_20260710%WP3301%HOMO SAPIENS MFAP5 mediated ovarian cancer cell motility and invasiveness TNNC1 CREB1 PRKCQ PLCG1 MAPK3 ITGB3 RYR3 MFAP5 ITGAV JUN MAPK1 SLEEP REGULATION%WIKIPATHWAYS_20260710%WP3591%HOMO SAPIENS Sleep regulation HEL-S-2 NPY2R CACNA1I CRH MRGPRX2 NLGN1 GHRH NPS HCRTR2 HCRTR1 GHRL ADORA2A TH DRD2 CHRNB2 DRD1 UTS2R HTR2A DRD3 OXT DLAT PER3 OXTR MTNR1B UTS2 STAR BTBD9 PTGDR FOS NPAS2 SLC29A1 ADA IL18 IL6 HEDGEHOG SIGNALING%WIKIPATHWAYS_20260710%WP4249%HOMO SAPIENS Hedgehog signaling SHH BCL2 BOC SMURF1 DKFZp686L0365 SMO DHH HHIP KIF3A SUFU CSNK1A1L ADRBK1 EVC2 CSNK1G3 CSNK1A1 CCND1 SMURF2 PTCH2 FBXL17 KIF7 PRKACG EVC SPOPL GAS1 CSNK1G2 SPOP hCG_2014051 CDON CSNK1D PTCH1 CSNK1G1 GPR161 CCND2 GLI3 FAMILIAL HYPERLIPIDEMIA TYPE 1%WIKIPATHWAYS_20260710%WP5108%HOMO SAPIENS Familial hyperlipidemia type 1 PLTP GPIHBP1 LDLR ANGPTL3 SEL1L APOA2 LPL APOA4 ANGPTL8 ANGPTL4 APOA5 LMF1 LIPC APOC2 HUNGER AND SATIETY%WIKIPATHWAYS_20260710%WP5445%HOMO SAPIENS Hunger and satiety GHRL MC4R LEP NPY PYY AgRP GCG POMC SMC1 SMC3 ROLE IN DNA DAMAGE CORNELIA DE LANGE SYNDROME%WIKIPATHWAYS_20260710%WP5118%HOMO SAPIENS SMC1 SMC3 role in DNA damage Cornelia de Lange Syndrome BRCA1 MRE11A ATM NBN PAXIP1 MDC1 SMC3 RAD18 SMC1A RAD50 RAD21 NEUROINFLAMMATION AND GLUTAMATERGIC SIGNALING%WIKIPATHWAYS_20260710%WP5083%HOMO SAPIENS Neuroinflammation and glutamatergic signaling GFAP PRKCA SLC2A3 CAMK2D PHGDH DLAT STAT3 PSPH ADCY3 ADCY1 DLD ADCY8 HEL-S-15 GLS2 SHMT1 HEL-S-51e JAK1 PDHA1 SLC17A6 SLC17A7 TGFBR1 TGFBR2 TGFBR3 IL13RA1 SLC38A1 TNF PSAT1 SMAD2 DISC1 STAT1 LIF PPP1CC HEL-S-80p CREB1 NGF BDNF LTA CAMKK1 GRIN2B GRIN1 ARC GRIN3B GRIN3A PIG59 CAMKK2 GRIA2 SLC1A1 SLC1A2 SLC1A3 MAPK1 GRIA3 GRIA4 SLC38A5 MAPK3 GRIK5 PRKCB GRIK3 IL1R2 GRIK1 GRIK2 PLCB3 SLC1A4 GRM2 PLCB4 GRM8 PLCB1 CAMK4 PLCB2 CALM1 CAMK2A IL10RB CAMK2G IFNGR1 IL1A SLC6A9 IFNGR2 IRS1 FOS DAO TNFRSF1A SOCS3 IL6 IFNG IGF1 TRAF5 BCL2 IL6R IL6ST IL1R1 SMAD4 TNFRSF1B IL1B INSR FGF2 NFKB1 NFKB2 NELF SLC38A3 SLC7A10 LRRC8C IL12B LRRC8D LRRC8E IL13 IL10RA IL10 IL4 TGFB1 IL12A CNTF GLS INFLUENZA A VIRUS INFECTION%WIKIPATHWAYS_20260710%WP1438%HOMO SAPIENS Influenza A virus infection BCL2 LIPID METABOLISM IN SENESCENT CELLS%WIKIPATHWAYS_20260710%WP5149%HOMO SAPIENS Lipid metabolism in senescent cells PLA2G12A CDKN1A PLA2G4F PLA2G7 PLA2G12B SLCO2A1 PLA2G4D PLA2G4E PLA2G4C PTGS2 PLA2G1B PLA2G10 PLA2G2D PLA2G3 PLA2G5 PLA2G6 HRAS ALOX5 NANOPARTICLE TRIGGERED AUTOPHAGIC CELL DEATH%WIKIPATHWAYS_20260710%WP2509%HOMO SAPIENS Nanoparticle triggered autophagic cell death BCL2 CHAF1A VMP1 ATG3 ATG14 ATG10 ATG16L1 ATG12 ULK1 ATG9B TSC2 MAP1LC3A AMBRA1 SH3GLB1 INSR UVRAG TSC1 INS ULK2 DKFZp686F0183 INHIBITION OF EXOSOME BIOGENESIS AND SECRETION BY MANUMYCIN A IN CRPC CELLS%WIKIPATHWAYS_20260710%WP4301%HOMO SAPIENS Inhibition of exosome biogenesis and secretion by manumycin A in CRPC cells HGS PDCD6IP MAPK3 RRAS2 RAB27A RAF1 ARAF RAB5A RAB5B RRAS RAB5C HNRNPH1 HRAS NRAS MAPK1 CORI CYCLE%WIKIPATHWAYS_20260710%WP1946%HOMO SAPIENS Cori cycle PFKP SLC2A2 HEL-S-87p HEL-S-133P GPT PGAM1 HEL-S-68p HEL-S-49 SLC2A4 INS HEL-S-162eP 7 OXO C AND 7 BETA HC PATHWAYS%WIKIPATHWAYS_20260710%WP5064%HOMO SAPIENS 7 oxo C and 7 beta HC pathways CYP27A1 EPHX2 AMACR ACOT9 SLC27A2 SLC27A5 ACOT8 ACOT7 ACOT11 ACOT12 ACOT13 CYP7A1 THEM5 ACOT6 ACOT4 DHCR7 BAAT HSD11B1 HSD11B2 NPC1 EBP DBP NPC2 NPHP1 DELETION SYNDROME%WIKIPATHWAYS_20260710%WP5399%HOMO SAPIENS NPHP1 deletion syndrome RPGRIP1L MAPK3 FLNB FLNA INVS PTK2B NPHP1 MAPK1 NEPHROTIC SYNDROME%WIKIPATHWAYS_20260710%WP4758%HOMO SAPIENS Nephrotic syndrome PAX2 CD2AP INF2 APOL1 COL4A4 COL4A3 COL4A5 LMNA MYH9 LMX1B CD151 ITGB4 LAMB2 COQ8B MYO1E NPHS1 NPHS2 WT1 ALG1 CUBN COQ2 WDR73 CYP11B2 SCARB2 CTLA4 SMARCAL1 ZMPSTE24 PTPRO GPC5 YARS EMP2 COQ6 ARHGAP24 PLCE1 SYNPO TRPC6 E2F3 HEL-S-47e ACTN4 IDO METABOLIC PATHWAY%WIKIPATHWAYS_20260710%WP5414%HOMO SAPIENS IDO metabolic pathway AADAT KMO KYAT3 KYAT1 IDO2 IDO1 GOT2 TNF TDO2 IFNG KYNU WARBURG EFFECT MODULATED BY DEUBIQUITINATING ENZYMES AND THEIR SUBSTRATES%WIKIPATHWAYS_20260710%WP5216%HOMO SAPIENS Warburg effect modulated by deubiquitinating enzymes and their substrates VEGFA HEL-S-133P SIRT7 U2AF2 PGAM1 G6PC1 HEL-S-68p FOXO1 PIK3CA HK2 FBP1 VHL MTOR KDR HIF1A OTUB2 USP37 OTUD7B USP44 MYC USP28 USP19 OTUD6B DOPAMINERGIC NEUROGENESIS%WIKIPATHWAYS_20260710%WP2855%HOMO SAPIENS Dopaminergic neurogenesis SHH OTX2 LMX1A NEUROG2 MSX1 SLC18A2 LMX1B CDKN1C DDC WNT1 SLC6A3 NEUROD1 NKX6-1 NKX2-2 FOXA2 TH SOX2 HEL-S-53e STAT3 TGFB1 RET ASCL1 FGF8 GBX2 PITX3 EN2 EN1 EXRNA MECHANISM OF ACTION AND BIOGENESIS%WIKIPATHWAYS_20260710%WP2805%HOMO SAPIENS exRNA mechanism of action and biogenesis XPO5 DGCR8 DROSHA AGO2 DICER1 ERI1 EFFECT OF DASATINIB ON THE BCR ABL SIGNALING PATHWAY%WIKIPATHWAYS_20260710%WP5493%HOMO SAPIENS Effect of dasatinib on the BCR ABL signaling pathway BCL2 BCLAF1 GAB2 SPAG1 MAPK3 GRB2 HEL-S-102 MEF2C ARAF RPS6KA1 INPP5D AKT3 HRAS PIK3R1 ATF2 NRAS DOK1 HSPB2 CRKL SHC2 SOS1 RAF1 PIK3CA CRK BCL9 SHC3 SHC1 SRC SHC4 PXN VAV1 MAPK14 BCR CBL MAPK11 MAP3K2 MAPK1 EIF4B BENZO A PYRENE METABOLISM%WIKIPATHWAYS_20260710%WP696%HOMO SAPIENS Benzo a pyrene metabolism HEL-S-165mP EPHX1 CYP1A1 AKR1C1 AKR1C2 CYP1B1 AKR1C4 CYP3A4 ALTERNATIVE PATHWAY OF FETAL ANDROGEN SYNTHESIS%WIKIPATHWAYS_20260710%WP4524%HOMO SAPIENS Alternative pathway of fetal androgen synthesis HSD17B3 POR HSD17B6 CYP11A1 STAR AKR1C2 HSD3B2 AKR1C4 SRD5A2 CYP17A1 AUTOSOMAL RECESSIVE OSTEOPETROSIS PATHWAYS%WIKIPATHWAYS_20260710%WP4788%HOMO SAPIENS Autosomal recessive osteopetrosis pathways TCIRG1 TNFRSF11A TNFSF11 CLCN7 IKBKB OSTM1 SNX10 RAB7A PLEKHM1 NFKB1 TRAF6 HIJACK OF UBIQUITINATION BY SARS COV 2%WIKIPATHWAYS_20260710%WP4860%HOMO SAPIENS Hijack of ubiquitination by SARS CoV 2 CBFB NAE1 UBA3 ELOC RBX1 APOPTOSIS MODULATION AND SIGNALING%WIKIPATHWAYS_20260710%WP1772%HOMO SAPIENS Apoptosis modulation and signaling NFKBIA MAPK3 BNIP3 TNFRSF6B PIDD1 AIFM1 IL1R2 PTRH2 BIRC7 NAIP BLK BIRC5 BAG3 TRADD SEPTIN4 CASP9 TNFRSF10D CASP8 CASP3 CYCS RIPK1 FADD BIRC3 PRKD1 HTRA2 MAPK8 SMIM40 BCL2L11 TNFSF10 MAP3K14 BMF BAK1 MAP3K5 HRK MCL1 CASP6 CASP10 CASP4 DFFB JUN DFFA CDKN2A DIABLO BBC3 FOS CRADD TNFRSF1A TNFSF6 TRAF6 BCL2 BAX BCL2L1 BCL2A1 BCL2L10 PMAIP1 BCL2L2 BOK IL1R1 BIRC2 APAF1 BIK TNFRSF10C BAD PTPN13 TNFRSF10A TNFRSF1B TRAF3 TNFRSF10B NFKB1 CASP2 AIFM2 IKBKB TNFRSF25 MADD IRAK1 MYD88 MALATE ASPARTATE SHUTTLE%WIKIPATHWAYS_20260710%WP4315%HOMO SAPIENS Malate aspartate shuttle SLC25A11 GOT2 HEL-S-32 SLC1A3 NON CLASSICAL ROLE OF VITAMIN D%WIKIPATHWAYS_20260710%WP5133%HOMO SAPIENS Non classical role of vitamin D ACE2 CYP2R1 AGTR1 REN AGTR2 CYP27B1 LEPTIN SIGNALING%WIKIPATHWAYS_20260710%WP2034%HOMO SAPIENS Leptin signaling MAPK3 GRB2 FOXO1 FYN CFL2 MTOR KPNA4 KHDRBS1 SOCS2 RPS6KB1 SOCS7 ARHA EIF4E CISH STAT3 MAPK8 SH2B1 IRS1 MAPK14 SOCS3 JAK1 STAT5B PTPN11 PDE3B LEPR NCOA1 ERBB2 LEP RPS6KA1 STAT1 ACACB GSK3B PRKAA1 PLCG1 RAC1 PRKAA2 BAD PTEN RPS6 NFKB1 HRAS PIK3R1 MAP2K1 PLCG2 MAP2K2 EIF4EBP1 CREB1 CHUK IKBKB SP1 IKBKG SOS1 RAF1 SHC1 SRC PIK3R2 ROCK1 GSK3A RELA ROCK2 ACACA REL PTPN1 CDC42 MAPK1 NCRNAS IN WNT SIGNALING IN HEPATOCELLULAR CARCINOMA%WIKIPATHWAYS_20260710%WP4336%HOMO SAPIENS ncRNAs in Wnt signaling in hepatocellular carcinoma CHD8 CSNK2B LRP6 PORCN FZD1 CSNK1A1 FZD7 SOX7 FZD8 CER1 CTNNBIP1 SFRP4 SOX17 KREMEN1 SENP2 SFRP5 CTBP2 CXXC4 NKD1 NKD2 ELAVL1 NOTUM FZD2 SOST DKK1 FZD5 WNT2B JUN LRP5 SFRP1 FRAT1 CCND3 CCND2 MYC WIF1 WNT5B AXIN1 WNT16 DKK2 LEF1 NLK DVL1 DVL2 DVL3 FRAT2 WNT1 WNT3 WNT4 WNT10B TCF7L2 CSNK1A1L WNT10A TCF7L1 MTDH CCND1 GSK3B FZD9 WNT3A WNT7B DKK4 FZD10 WNT7A FOSL1 APC KLF4 CTBP1 hCG_2014051 CSNK2A1 RYK CSNK2A3 CSNK2A2 ROR1 ROR2 EZH2 FZD3 DNA DAMAGE RESPONSE%WIKIPATHWAYS_20260710%WP707%HOMO SAPIENS DNA damage response CCNE2 CDK2 PIDD1 CHEK2 CHEK1 CASP9 CASP8 CASP3 CYCS PRKDC SESN1 PML RAD17 CCNB3 RB1 HUS1B CDKN1A BRCA1 TP53AIP1 TLK1 SFN GADD45B CDC2 GADD45G ATR CDKN1B BBC3 CCND3 CCND2 RFC1 MYC DDB2 BAX PMAIP1 RAD52 RAD50 RAD51 CDK5 MRE11A CCND1 NBN RRM2B APAF1 GADD45A TNFRSF10B SMC1A FANCD2 MDM2 ATM CREB1 CDK6 CDK4 RAD1 CCNE1 ATRIP CCNB2 CCNB1 H2AX RAD9A TLK2 GLYCOSAMINOGLYCAN SYNTHESIS IN FIBROBLASTS%WIKIPATHWAYS_20260710%WP5395%HOMO SAPIENS Glycosaminoglycan synthesis in fibroblasts HS3ST2 HS3ST3A1 HS3ST3B1 CHST7 CHST11 CHST12 CHST13 CHST14 CHST1 CHPF XYLT2 EXTL2 CHST3 EXTL1 CHSY1 CHSY3 CSGALNACT1 CHPF2 B3GAT3 B3GAT2 GLCE B3GAT1 XYLT1 CSGALNACT2 B3GALT6 UST EXT1 EXT2 HS6ST1 HS6ST2 HS6ST3 NDST3 HS2ST1 HS3ST1 HIF1A AND PPARG IN HYPERTROPHIC CARDIOMYOPATHY%WIKIPATHWAYS_20260710%WP2456%HOMO SAPIENS HIF1A and PPARG in hypertrophic cardiomyopathy HEL-S-133P CD36 HIF1A GPD1 HEL-S-49 HMFN0839 HEL-S-162eP PPARG EFFECT OF PROGERIN ON GENES INVOLVED IN PROGERIA%WIKIPATHWAYS_20260710%WP4320%HOMO SAPIENS Effect of progerin on genes involved in progeria LEF1 H3F3B MBD2 RBBP7 KDM1A HEL25 CBX3 HDAC2 CBX1 MTA3 CHD4 HDAC1 CHD3 H3C15 RBBP4 SUV39H1 MTA2 RB1 MBD3 H3C8 PHASE I BIOTRANSFORMATIONS NON P450%WIKIPATHWAYS_20260710%WP136%HOMO SAPIENS Phase I biotransformations non P450 PON3 PON2 ESD CES2 PON1 HEL126 LIPA CES1 RNA POLYMERASE II TRANSCRIPTION THE PREINITIATION COMPLEX%WIKIPATHWAYS_20260710%WP5563%HOMO SAPIENS RNA polymerase II transcription the preinitiation complex TBP MED14 NELFCD NELFA NELFE TAF12 NELFB MED23 TAF13 TAF8 MED27 GTF2B TAF9 GTF2E2 MED19 POLR2A CCNC POLR2B MED16 POLR2C MED18 POLR2F MED17 POLR2G MED12 POLR2H MED11 POLR2I MED13 POLR2J MED10 POLR2K MED8 MED9 MED4 TAF7 GTF2F1 TAF6 MED26 MED6 TAF5 MED28 MED22 MED25 MED24 MED21 GTF2A1 CTDP1 MED30 MED31 POLR2M TAF10 MED15 TAF11 TRFP CRSP9 TAF4 IXL POLR2L TAF3 MED1 TAF1 CDK8 THRA POLR2D MINERALOCORTICOID BIOSYNTHESIS%WIKIPATHWAYS_20260710%WP5279%HOMO SAPIENS Mineralocorticoid biosynthesis UGT2B7 AKR1C1 AKR1D1 AKR1C2 AKR1C4 SRD5A2 HSD11B1 HSD11B2 CYP21A2 UGT1A10 CYP11B2 FACT COMPLEX AND DNA DOUBLE STRAND BREAK REPAIR%WIKIPATHWAYS_20260710%WP5564%HOMO SAPIENS FACT complex and DNA double strand break repair ATM H4C9 NASP HIST1H4L RAD51 NBN MDC1 SETD2 RNF168 PRKDC TP53BP1 H1-1 RNF8 SUPT16H XRCC5 SSRP1 AFFECTED PATHWAYS IN DUCHENNE MUSCULAR DYSTROPHY%WIKIPATHWAYS_20260710%WP5356%HOMO SAPIENS Affected pathways in Duchenne muscular dystrophy NFKBIA CACNA1F FGA DMD CACNG1 CACNA1S ITPR2 CASP9 CAMK2D CASQ1 PRG3 PLA2G2A HEL-S-78p MPO IL1A AGTR1 SSPN SNTB1 SLC25A5 MMP2 NOX4 IL6 TRPC3 CYBB opn TGFBR1 TGFBR2 TNF TRPC1 SMAD2 PPIF SMAD4 PRKAA1 FKBP1A PRKAA2 MCU ATP2A1 CAPN3 IL1B NFKB1 MCUB SCX SLN TRDN ELANE NOS2 STIM1 TOMM20 RYR1 IL10 TNNI1 TGFB1 SGCA DAG1 CACNA2D1 CTGF TRPC6 ORAI1 CACNB1 MMP9 PEPTIDE GPCRS%WIKIPATHWAYS_20260710%WP24%HOMO SAPIENS Peptide GPCRs CCR10 NTSR2 NMBR FPR2 OPRK1 HCRTR2 HCRTR1 BRS3 CCKAR IL8RB MC1R AVPR1B AVPR1A MC3R CCR8 CCKBR FSHR GHSR OPRD1 MC4R BDKRB2 CXCR5 AGTR1 CXCR6 BDKRB1 AGTR2 CCR6 CCR5 MC5R TSHR NPY2R CXCR1 LHCGR NPY1R CXCR4 CCR1 C5AR1 CXCR3 CCR7 C3AR1 CCR4 CCR3 CCR2 SSTR2 ATP8A1 GNRHR TACR2 OXTR TAC4 GRPR EDNRA TACR3 EDNRB CX3CR1 NPY5R FPRL2 AVPR2 TRHR OPRM1 SSTR3 SSTR4 FPR1 SSTR5 MC2R GALR3 GALR2 TACR1 GALR1 NPY4R NTSR1 COMPLEMENT MEDIATED INFLAMMATION OF PULMONARY ALVEOLUS IN COVID 19 HYPOTHETICAL PATHWAY %WIKIPATHWAYS_20260710%WP5148%HOMO SAPIENS Complement mediated inflammation of pulmonary alveolus in COVID 19 hypothetical pathway ACE2 HEL-S-62p C3AR1 C8A MASP2 FCN1 COLEC11 C6 C7 C9 C5AR1 SODIUM CHANNEL IN EPILEPSY%WIKIPATHWAYS_20260710%WP5598%HOMO SAPIENS Sodium channel in epilepsy WEE1 SCN1A BACE1 PSEN1 FYN SCN5A TNF GSK3B SCN8A SCN2A SCN4B FGF14 CALM1 CAMK2A FGF13 FGF12 PTPRN SCN11A PDCD10 SCN9A SCN7A SCN3B SCN3A SCN1B MAPK8IP2 SCNM1 SCN4A SCN2B RNF121 PRRT2 NEDD4 SCN10A HLA C ALLOTYPES INTERACTIONS WITH KIR ON DNK CELLS%WIKIPATHWAYS_20260710%WP5580%HOMO SAPIENS HLA C allotypes interactions with KIR on dNK cells FYN TNF CSF2 PRKCA SYK HLA-C KIR2DL1 KIR2DL3 VAV1 TYROBP ELF3 NLRP7 PRKCQ PLCG1 NLRP2 PTPN6 RAC1 LCP2 LAT IFNG OVARIAN INFERTILITY%WIKIPATHWAYS_20260710%WP34%HOMO SAPIENS Ovarian infertility TBP GJA4 LHCGR PRLR NR3A2 PGR RAD51 TSC2 MTOR NCOR1 TSC1 FMR1 EGR1 CEBPB FSHR ATM NR1i1 CREB1 CDK4 NR5A1 PTGER2 CDKN1B SMPD1 CCND2 FIGLA DAZL MSH5 INHA DMC1 ZP3 ZP2 SYNE2 KCNQ2 RELATED EPILEPSIES%WIKIPATHWAYS_20260710%WP5360%HOMO SAPIENS KCNQ2 related epilepsies BACE1 P2RY1 BDKRB2 CHRM1 AGTR1 KCNQ2 CSNK2A1 PRKCA SCN1B KCNQ3 AKAP5 STX1A CALM1 PPP1R10 PPP3CC PLCG2 PHOSPHOINOSITIDE 3 KINASE PI3K FAMILY%WIKIPATHWAYS_20260710%WP5472%HOMO SAPIENS Phosphoinositide 3 kinase PI3K family PIK3C2G PIK3R4 PIK3R2 PIK3R5 PIK3C2B PIK3CD PIK3R3 PIK3CA PIK3R1 STRIATED MUSCLE CONTRACTION PATHWAY%WIKIPATHWAYS_20260710%WP383%HOMO SAPIENS Striated muscle contraction pathway MYH6 TTN DMD TCAP DES TMOD1 HEL-S-273 TNNI1 TNNI2 TNNI3 HEL-S-108 TPM3 MYL4 TNNC1 TPM1 HEL113 TNNC2 ACTA2 ACTN2 ACTA1 MYL1 TNNT1 MYL2 MYL3 ACTG1 TNNT3 MYOM1 MYH8 MYBPC3 ACTN4 MAPK CASCADE%WIKIPATHWAYS_20260710%WP422%HOMO SAPIENS MAPK cascade LAMTOR3 SOS2 SIPA1 MAPK10 MAPK3 GRB2 ARAF RASA3 PLCB3 MAP3K1 RRAS HRAS NRAS MAP2 MAP2K1 MAP2K2 MAP2K6 SOS1 RAF1 MAP2K3 MAP2K4 JUN MAP3K12 MAPK14 MAPK12 MBP MAP3K2 MAPK1 KENNEDY PATHWAY FROM SPHINGOLIPIDS%WIKIPATHWAYS_20260710%WP3933%HOMO SAPIENS Kennedy pathway from sphingolipids PTDSS2 CEPT1 SGPL1 CHKB PCYT1B PEMT CHPT1 PTDSS1 CHKA PISD SPHINGOLIPID METABOLISM INTEGRATED PATHWAY%WIKIPATHWAYS_20260710%WP4726%HOMO SAPIENS Sphingolipid metabolism integrated pathway DEGS2 SPTLC1 PLPP3 PLPP2 CERS3 SPHK2 CERS5 SPHK1 CERS6 CERK SGMS1 LASS1 UGT8 SGMS2 SGPP1 UGCG SGPP2 DEGS1 KDSR SGPL1 SPTLC2 CERS2 SMPD1 PLPP1 OSTEOBLAST SIGNALING%WIKIPATHWAYS_20260710%WP322%HOMO SAPIENS Osteoblast signaling COL1A1 PTH TNFSF11 BGLAP PTH1R SLC17A2 ITGB3 TNFRSF11B ITGAV FGF23 IBSP PDGFRA HINT1 PATHWAY%WIKIPATHWAYS_20260710%WP5523%HOMO SAPIENS HINT1 pathway CDK7 MAPK9 KARS1 ERCC2 USF2 HINT1 MNAT1 RUVBL2 SH3RF1 NFATC2 CCNH JUN RUVBL1 GTF2H2C_2 FOS TCF4 GTF2H2 GTF2H3 NFKB1 GTF2H4 GTF2H5 TP53 NETWORK%WIKIPATHWAYS_20260710%WP1742%HOMO SAPIENS TP53 network CDKN1A BCL2 MDM2 OTX2 BAX ATM TP73 TNFSF10 PMAIP1 BOK CDKN2A TP63 BBC3 GADD45A SUMO1 MYC PATHOPHYSIOLOGICAL ROLES OF DUX4 IN FSHD1%WIKIPATHWAYS_20260710%WP5342%HOMO SAPIENS Pathophysiological roles of DUX4 in FSHD1 CDKN1A VEGFA NR3A2 MYOG H3Y1 PPARGC1A H3Y2 DUX4 MYOD1 MYF5 FBXO32 PAX7 EP300 RET TRIM63 MYC ADRB2 PSORIASIS MECHANISM AND THERAPIES%WIKIPATHWAYS_20260710%WP5537%HOMO SAPIENS Psoriasis mechanism and therapies TYK2 IL12B IL17RC CCL20 IL22 IL23A IL17F TNF HLA-C IL17A IL12RB1 CCR6 IL23R IL1B CXCL8 CXCL1 STAT3 GDNF SIGNALING%WIKIPATHWAYS_20260710%WP5143%HOMO SAPIENS GDNF signaling FAS LIGAND PATHWAY AND STRESS INDUCTION OF HEAT SHOCK PROTEINS%WIKIPATHWAYS_20260710%WP314%HOMO SAPIENS Fas ligand pathway and stress induction of heat shock proteins FAF1 RIPK2 BCL2 PS1TP5BP1 LMNA HEL-S-102 TNF SPTAN1 ARHGDIB CASP9 NFX1 CASP8 MAP3K1 CASP3 APAF1 CYCS FADD PRKDC RB1 LMNB2 MAPK8 SMIM40 MAPKAPK3 IL1A MAPKAPK2 CASP6 CASP10 MAP2K4 DFFB JUN DFFA ACTA1 PAK1 MAP3K7 TNFSF6 ACTG1 WNT SIGNALING AND PLURIPOTENCY%WIKIPATHWAYS_20260710%WP399%HOMO SAPIENS Wnt signaling and pluripotency MAPK10 PRKCB LRP6 PRKCA PTPA ZBTB33 FZD1 LRRK2 MMP7 FZD7 PPM1J FZD8 ARHA SOX2 CTBP2 CTNND1 PRKD1 NKD1 NKD2 FZD2 ESRRB CREBBP FZD5 NR1C2 FZD4 MAP2K4 WNT2B PRKCE JUN LRP5 PRKCQ FRAT1 CCND3 CCND2 PPP2R5E MYC PPP2R3B MAP3K7 WNT5B PPP2R3A AXIN1 PPP2R2C PPP2R5C PPP2R2B WNT16 LEF1 NLK POU5F1 MAPK9 DVL1 DVL2 DVL3 WNT1 WNT3 WNT4 WNT10B TCF7L2 WNT10A TCF7L1 CCND1 GSK3B PPP2R1A EP300 FZD9 WNT3A WNT9B WNT7B FZD10 PRKCI WNT7A PRKCH FOSL1 PRKCZ APC NFYA PPP2R2A CTBP1 PPP2R1B PPP2CA hCG_2014051 LDLR FOXD3 AXIN2 PAFAH1B1 CD44 FZD3 INFLUENCE OF LAMINOPATHIES ON WNT SIGNALING%WIKIPATHWAYS_20260710%WP4844%HOMO SAPIENS Influence of laminopathies on Wnt signaling LEF1 opn TARBP2 LMNA AGO2 SLC2A4 WNT10B TCF7L2 CSNK1A1L TCF7L1 CSNK1A1 CCND1 GSK3B TOR1AIP1 FNTA ICMT APC CEBPB CEBPD PPARG CDK6 RUNX2 HMGA2 ZMPSTE24 EMD CEBPA HES1 DICER1 AXIN1 HES5 INHIBITORS OF METABOLISM IN MELANOMA THERAPY%WIKIPATHWAYS_20260710%WP5609%HOMO SAPIENS Inhibitors of metabolism in melanoma therapy HEL-S-133P HEL-S-281 CPT1A MAPK3 MLST8 HEL-S-304 ARAF RPS6KA1 PPARGC1A GPX4 HEL-S-30 RPTOR MTOR NAMPT HEL-75 DLAT MAP2K1 MAP2K2 RPS6KA2 SLC16A3 RAF1 DLD PFKFB2 PDHA1 PKLR GLS MAPK1 ACSS1 OVERVIEW OF PROINFLAMMATORY AND PROFIBROTIC MEDIATORS%WIKIPATHWAYS_20260710%WP5095%HOMO SAPIENS Overview of proinflammatory and profibrotic mediators CXCL6 CXCL9 CXCL3 TSLP CXCL2 IL36G PPBP IL1F10 IL20 CCL8 IL26 CCL4 IL24 CCL3 IL27 CCL1 CX3CL1 PF4V1 IL11 IL19 CCL14 CCL13 TNLG7A CCL19 CCL18 CSF2 CCL25 CCL24 CCL23 IL31 IL37 CSF3 EPO CCL4L2 CXCL17 opn CXCL14 TNF IL36RN LIF LTA XCL2 XCL1 CCL7 TNFSF13 CCL5 MMP9 VEGFA OSM CXCL11 IFNA5 IFNA4 IFNA7 IFNA6 IFNA1 CCL3L3 IFNA2 CSF1 IFNA8 CCL16 IFNL2 IFNL1 IFNL3 IFNA21 IFNA13 IFNA14 IFNA16 IL1A IFNA17 IFNW1 IL22 IFNK IFNA10 CTF1 EBI3 IL2 IL6 IL18 CCL17 IFNG CCL11 IL3 CCL15 IL33 CCL22 CCL21 IFNB1 MMP3 CCL27 PF4 AREG CCL26 IL1B CXCL13 NFKB1 IL-21 CXCL8 CXCL16 IL25 CXCL1 CXCL5 CCL2 IL12B CCL20 IL13 CXCL12 IL23A IL17F IL10 IL17D IL4 IL17C IL5 CCL28 TGFB1 IL17B IL17A IL12A CNTF IL1RN IL36A IL36B IL7 IL9 IRON METABOLISM DISORDERS%WIKIPATHWAYS_20260710%WP5172%HOMO SAPIENS Iron metabolism disorders FTH1 TF CP HFE FTL UQCRFS1 SLC11A2 STEAP3 TFRC TFR2 SLC40A1 CYBRD1 HAMP HEPH PANK2 SEROTONIN RECEPTOR 4 6 7 AND NR3C SIGNALING%WIKIPATHWAYS_20260710%WP734%HOMO SAPIENS Serotonin receptor 4 6 7 and NR3C signaling MAP2K2 ATF1 CREB1 MAPKAPK2 MAPK3 HTR4 GNAS HTR6 HTR7 NR3C1 RAP1A EGR1 RPS6KA5 MAP2K1 MAPK1 METHYLATION PATHWAYS%WIKIPATHWAYS_20260710%WP704%HOMO SAPIENS Methylation pathways PNMT TPMT MAT1A NNMT INMT NANOPARTICLE MEDIATED ACTIVATION OF RECEPTOR SIGNALING%WIKIPATHWAYS_20260710%WP2643%HOMO SAPIENS Nanoparticle mediated activation of receptor signaling MAPK10 COL1A1 MAPK9 GRB2 AREG AKT3 PIK3CD HRAS NRAS MAP2K1 MAP2K2 EGFR MAPK8 ITGA1 SOS1 RAF1 TLN1 SRC PXN ITGB1 MAPK14 MAPK12 MAPK13 MAPK11 MAPK1 2Q21 1 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260710%WP5223%HOMO SAPIENS 2q21 1 copy number variation syndrome CCDC74A POTEE GPR148 CCDC42 ARHGEF4 CDC27 RAC1 ARHA TUBA2 AMER3 STMN2 APC MZT2A STAT3 FAM168B 15Q11Q13 COPY NUMBER VARIATION%WIKIPATHWAYS_20260710%WP5407%HOMO SAPIENS 15q11q13 copy number variation KAT2B ANKRD2 GJC2 HDAC1 CALM1 CXADR CREBBP SPEF1 SMC5 SMC6 ANKRD32 GOLGA8T NSMCE3 NSMCE2 NSMCE1 GOLGA8K GOLGA8J GJD3 TJP1 CANX MYZAP NECAB3 LYPD6 TJP3 ENTREP2 UBN1 MTMR10 MLSN2 SLF2 CGN STXBP1 APP STX1B CDC42BPB GOLGA8R STX1A KLF13 OTUD7A GOLGA8O CHRNA7 GOLGA8Q TRPM1 FANCD2 GOLGA8H FAN1 GJA1 RELA SIN3A CCL5 MONOAMINE GPCRS%WIKIPATHWAYS_20260710%WP58%HOMO SAPIENS Monoamine GPCRs CHRM5 CHRM3 CHRM2 CHRM1 HTR2B HTR5A HRH1 DRD2 HRH2 DRD1 HTR2A DRD3 DRD4 HTR1E DRD5 HTR1F ADRB3 HTR1D HTR1A HTR1B HTR4 ADRA1B ADRA1A HTR6 HTR7 ADRA1D ADRB1 ADRB2 ADRA2C ADRA2B CHRM4 ADRA2A NEUROGENESIS REGULATION IN THE OLFACTORY EPITHELIUM%WIKIPATHWAYS_20260710%WP5265%HOMO SAPIENS Neurogenesis regulation in the olfactory epithelium RELN NGFR MAP1B APP ID1 PSEN1 MEF2C NEUROD1 CDK5R1 CDK5 DISC1 NDEL1 MRE11A GHRL GSK3B GIG8 AGRN NTRK3 SOX2 TCF4 NTRK1 DAB1 NRG1 MAP2 STAT3 NTRK2 NUMB ERBB4 NGF PLXND1 RTN4R BDNF CXCL12 KDM1A RTN4 NOTCH1 IL17A VLDLR TCF3 PAFAH1B1 RET ASCL1 LRP8 MYC NEUROG3 FAIM HES1 OXYSTEROLS DERIVED FROM CHOLESTEROL%WIKIPATHWAYS_20260710%WP4545%HOMO SAPIENS Oxysterols derived from cholesterol HSD3B7 SULT2B1 RORC CYP27A1 AMACR SLC27A2 SLC27A5 LBP NR1i2 NR3A2 BAAT CYP7B1 INSIG1 IL25 EBP EPHX2 ACOT9 ACOT8 AKR1D1 ACOT7 NR1H2 ACOT11 CYP3A4 ACOT12 CYP7A1 ACOT13 IL17F THEM5 IL17D CH25H ACOT6 IL17C ACOT4 IL17B IL17A DHCR7 CYP46A1 AKR1C4 SULT2A1 HSD11B1 HSD11B2 GPR183 DBP CYP8B1 PATHOGENESIS OF SARS COV 2 MEDIATED BY NSP9 NSP10 COMPLEX%WIKIPATHWAYS_20260710%WP4884%HOMO SAPIENS Pathogenesis of SARS CoV 2 mediated by nsp9 nsp10 complex PRG3 CD8B CD8A LBP HLA-DRB1 FYN ZAP70 IGLL1 LCK CD3G CD3E CRP MMP25 NRF CXCL8 IL6 HLA-DRB5 CD2 ATM SIGNALING IN DEVELOPMENT AND DISEASE %WIKIPATHWAYS_20260710%WP3878%HOMO SAPIENS ATM signaling in development and disease ATMIN PPP5C CEP63 CDK2 HEL-S-102 CHEK2 RAD50 AURKB CHEK1 CDK5 TSC2 MTOR MRE11A NBN MDC1 RIF1 KAT5 PRKDC TP53BP1 NFKB1 SMC1A ATF2 LMNB2 ATM STK11 ATR PPP2CA IKBKG MAPK14 MAPK12 RNF168 MAPK13 MAPK11 RNF8 PPM1D TRIM28 RBBP8 NHEJ1 HMGN1 RNF20 STING PATHWAY IN KAWASAKI LIKE DISEASE AND COVID 19%WIKIPATHWAYS_20260710%WP4961%HOMO SAPIENS STING pathway in Kawasaki like disease and COVID 19 NFKBIA GSDMD CHUK MITA IKBKB FCGR2A TBK1 IFNB1 IKBKG IRF3 NLRP3 RELA IL1B CGAS IKBKE NLRX1 NFKBIE NFKB1 REL F3 GAMMA GLUTAMYL CYCLE FOR THE BIOSYNTHESIS AND DEGRADATION OF GLUTATHIONE%WIKIPATHWAYS_20260710%WP4518%HOMO SAPIENS Gamma glutamyl cycle for the biosynthesis and degradation of glutathione GGCT OPLAH HEL-S-64p GCLC PCSK9 MEDIATED LDL RECEPTOR DEGRADATION%WIKIPATHWAYS_20260710%WP2846%HOMO SAPIENS PCSK9 mediated LDL receptor degradation PCSK9 LDLR ISOGLOBO SERIES SPHINGOLIPIDS%WIKIPATHWAYS_20260710%WP5311%HOMO SAPIENS Isoglobo series sphingolipids B3GALT5 NANOMATERIAL INDUCED APOPTOSIS%WIKIPATHWAYS_20260710%WP2507%HOMO SAPIENS Nanomaterial induced apoptosis BCL2 BAX BAK1 AIFM1 CASP6 CASP9 DIABLO CASP8 APAF1 PRF1 CASP3 CYCS FADD TNFSF6 HTRA2 PHYSICO CHEMICAL FEATURES AND TOXICITY ASSOCIATED PATHWAYS%WIKIPATHWAYS_20260710%WP3680%HOMO SAPIENS Physico chemical features and toxicity associated pathways HEL-S-44 TMSB4X GRB2 NCK1 FZD1 FZD7 MYLK FZD8 ARHA GPX1 CAMK1 FZD2 CDKN1A EGFR MAPK8 ERBB4 FZD5 FZD4 MAP2K4 CDKN1B JUN CBL MYC AXIN1 PFN3 WNT16 NEF3 ERBB2 NEFH DVL1 ACTR3 DAAM1 PFN4 PFN2 NEFL GSK3B PLCG1 FZD9 ACTR2 FZD10 APC MAP2K1 PPP2CA SOS1 RAF1 PFN1 TGFA SHC1 SRC ACTA1 ROCK2 MYL1 PAK1 MAPK1 FZD3 MITOCHONDRIAL GENE EXPRESSION%WIKIPATHWAYS_20260710%WP391%HOMO SAPIENS Mitochondrial gene expression MYEF2 PPARGC1B POLRMT CREB1 SP1 GABPB1 MTERF3 HCFC1 PPARGC1A MTERF1 GABPA NRF1 TFB1M PPP3CA CAMK4 ESRRA TFB2M PPRC1 TFAM WNT SIGNALING IN KIDNEY DISEASE%WIKIPATHWAYS_20260710%WP4150%HOMO SAPIENS Wnt signaling in kidney disease MAPK10 MAPK9 DVL1 DVL2 DVL3 WNT1 LRP6 WNT3 WNT4 WNT10B NPHP3 WNT10A FZD1 FZD7 FZD9 FZD8 WNT3A ARHA WNT7B WNT9B WNT7A FZD2 MAPK8 FZD5 FZD4 INVS WNT2B LRP5 WNT5B FZD3 WNT16 PURINE METABOLISM%WIKIPATHWAYS_20260710%WP4792%HOMO SAPIENS Purine metabolism AMPD1 IMPDH1 APRT ADSS ADA PNP XDH ADSL HEL-S-70p DGUOK TCA CYCLE NUTRIENT USE AND INVASIVENESS OF OVARIAN CANCER%WIKIPATHWAYS_20260710%WP2868%HOMO SAPIENS TCA cycle nutrient use and invasiveness of ovarian cancer EGFR MAPK3 JAK1 STAT3 MAPK1 ANTIVIRAL AND ANTI INFLAMMATORY EFFECTS OF NRF2 ON SARS COV 2 PATHWAY%WIKIPATHWAYS_20260710%WP5113%HOMO SAPIENS Antiviral and anti inflammatory effects of Nrf2 on SARS CoV 2 pathway HMOX1 NFKBIA GUCY1A2 GUCY1B1 KEAP1 TNF IRF3 MMP3 NQO1 IL1B NFKB1 CXCL8 GCLC GCLM NFE2L2 CCL2 ACE2 CHUK IKBKB TMPRSS2 RXRA IKBKG IL12A RELA IL6 SLC7A11 10Q11 21Q11 23 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260710%WP5352%HOMO SAPIENS 10q11 21q11 23 copy number variation syndrome BCL2 BMP2 ELOA JUND SLC18A3 ERCC5 BMPR1A ITCH DDX21 GDF5 PARG MYO1C LRRC18 OGDHL ARHGAP22 EIF4ENIF1 HSF4 RIF1 ChAT FAM170B HSF1 CEFIP VSTM4 MEN1 DRGX MYBBP1A KDM4D C10orf53 SMARCA5 DEK SIRT1 ATF2 RGMB BAZ1B TMEM273 PCNA MAPK8 DKFZp781O1323 UVSSA WDFY4 SMARCC2 DLD NLRP3 SIRT6 SMAD1 SMAD9 CUL5 NOG HIPPO YAP SIGNALING%WIKIPATHWAYS_20260710%WP4537%HOMO SAPIENS Hippo YAP signaling NF2 STK38L TNIK TEAD2 RASSF1 TEAD3 TEAD4 LATS1 LATS2 HEL-S-31 MAP4K1 MAP4K2 MINK1 MAP4K3 YAP1 WWTR1 ROS IN COVID 19 ENDOTHELIAL DYSFUNCTION%WIKIPATHWAYS_20260710%WP5258%HOMO SAPIENS ROS in COVID 19 endothelial dysfunction ACE2 IFNA1 TNFRSF1A NFKB1 TNF IFNAR1 NUCLEAR RECEPTORS META PATHWAY%WIKIPATHWAYS_20260710%WP2882%HOMO SAPIENS Nuclear receptors meta pathway DNAJC15 ALAS1 THBD AGER ARL5B SRGN NAV3 ACOX1 JUND ADGRF4 FOXO1 PRRG4 PPP1R14C ANKRD1 PTPA SLC39A2 SLC39A1 SLC39A3 SERPINB2 SLC6A19 ME1 SLC7A5 CYP1B1 SULT2A1 EPHA2 MGST3 MGST1 GSTT2 MGST2 CYP2C19 PDE4B SULT1A1 FABP1 CYP2B6 SLC19A2 CAP2 DBI GSTM4 GSTM3 GSTM2 FTH1 FGF19 GSTM1 SLC39A8 SLC39A14 GPAM CYP4F12 CDC37 CYP2C9 TGFA APOC3 CYP1A2 CYP1A1 GSTM5 SLC6A13 SLC6A11 APOA2 APOA5 MAFF RGS2 PLTP CPT1A SLC5A1 SLC6A8 GPX2 EHHADH ACADM UGT1A1 GPX3 SLC39A9 SLC39A6 SLC39A5 HEL-S-22 SLC6A18 SLC6A17 BAAT SLC6A16 BIRC3 HEL126 HEL-75 ALDH3A1 SLC5A8 SLC5A9 NRG1 CYP2A6 CES8 EGR1 CES3 EPHA3 UGT2B4 SLC5A2 SLC6A20 SLC5A3 FGF13 SLC5A4 CDC2 SLC2A9 HSP90AB1 UGT2B7 SLC6A5 SLC6A7 SLC6A9 SLC2A6 SLC2A7 SLC2A8 CYP3A4 SLC2A11 CYP7A1 SLC2A10 SLC2A13 CYP3A7 HEL-S-25 SLC39A11 SLC39A10 SLC39A13 UGT1A4 SLC39A12 BHLHB2 UGT1A3 SMVT UGT1A9 SLC5A12 SLC5A10 UGT1A7 CYP8B1 SRXN1 GSTA5 NCOA1 GSTA4 GSTA3 ABCB1 NR1i2 SLCO1B1 SRPX2 DNAJC7 PPARGC1A NR3C1 NCOA6 NQO1 ABCC5 AHR ANGPTL4 TXN CDK4 HEL-S-10 SRC MYOF HES1 SLC27A1 STOM CPT2 PTGS2 SLC2A2 SLC2A3 ALOX5AP PTGR1 IL11 STAT3 CYP4A11 ADH7 NR1C2 MFGE8 CES2 CES1 PCK1 NR1C1 POLK TGFBR2 TGFBR3 KEAP1 FTL SLC2A4 TNF SMARCA1 FGD4 CCND1 EP300 SMC1A FKBP5 NR1H3 SQSTM1 SCD AMIGO2 SPRY1 ACKR3 HEL-S-128m HGF HMOX1 KAT2B SNAI2 SLC2A14 FASN GCLC GCLM NFE2L2 B3GNT5 EGFR GADD45B NR1i1 JUNB DNAJB1 JUN CDKN1B IL2 SLC5A5 MYC ZIC2 IFNG SLC2A12 BAX POU5F1 HBEGF SLC27A5 MAFG CDKN1C SLC6A2 SLC6A3 BIRC2 S100P SLC5A7 IGFBP1 IL1B SERPINA1 NFKB2 ABCC3 ABCG8 ABCG5 TNFAIP3 ABCC2 CCL2 IL12B ABCB4 NR1I3 CCL20 NR1H4 GCC1 SP1 PDK4 ABCB11 TNS4 RXRA PLK2 NR0B2 CPEB4 EPB41L4B DNER ENC1 IL17B TGFB1 FGFBP1 EDN2 IL12A TSC22D3 CDC42EP3 AHRR PMP2 GPR153 SERTAD2 CAVIN2 PTGES3 KLK15 SLCO2B1 AIP SCNN1A SLC26A2 SLC7A11 ABHD2 IP6K3 FOCAL ADHESION%WIKIPATHWAYS_20260710%WP306%HOMO SAPIENS Focal adhesion CAV2 MAPK10 COL4A4 ZYX GRB2 PS1TP5BP1 sm-M20 LAMA5 FYN ARHGAP35 MYLK4 MYL5 VTN PRKCA MYL7 LAMB2 TLN2 BLK PARVA TXK MYL12A MYL12B MYL10 MYLK3 SRMS MYLK TNK1 PTK6 PARVB ARHA PARVG ARHGAP5 STYK1 RASGRF1 c-fgr IGF1R VAV1 FLNB opn PPP1R12C THBS1 EGF CCND1 TNC PPP1CC KDR GSK3B LAMA4 HEL-S-80p RAC1 PTEN XB LAMC1 PIK3CD THBS2 PIK3R3 COL4A2 COL4A1 COL5A3 PIK3R1 COL5A2 CRKL SHC2 RAF1 PIK3CA MYL11 PDGFD SHC4 PDGFC ACTN1 FLT1 MYL2 PAK1 COL2A1 HGF MAPK1 VEGFA COL1A1 RELN COL1A2 MAPK3 COMP PRKCB IBSP TNR COL4A6 CHAD BIRC3 EGFR MAPK8 LAMC2 VWF LAMA1 LAMA3 THBS4 PDGFRA THBS3 JUN CCND3 CCND2 LAMB3 FLNA LAMB1 PDGFA IGF1 BCL2 PIP5K1C MAPK9 ERBB2 ITGB3 MYLK2 ITGB4 ITGA2B HEL114 BIRC2 AKT3 TNK2 BAD ITGB8 RAC3 ITGAV ITGB7 ITGB6 HRAS VAV3 MAP2K1 ITGA4 PDPK1 ITGA2 ITGA1 HEL-S-28 VEGFB VAV2 VEGFC VEGFD RAPGEF1 ITGA7 ITGA6 SOS1 TLN1 CRK DOCK1 SHC3 SHC1 SRC PXN PIK3R2 ITGB1 RAP1A EMP2 ROCK1 ROCK2 PAK6 PAK4 ACTG1 VASP ACTN4 CAV3 CDC42 HEMESYNTHESIS DEFECTS AND PORPHYRIAS%WIKIPATHWAYS_20260710%WP5169%HOMO SAPIENS Hemesynthesis defects and porphyrias ALAS1 HMBS CPOX ALAS2 FECH UROD UROS UREA CYCLE AND RELATED DISEASES%WIKIPATHWAYS_20260710%WP4571%HOMO SAPIENS Urea cycle and related diseases ARG1 OTC NAGS GLS2 ASS1 SLC25A15 ASL SLC25A13 BIOMARKERS FOR UREA CYCLE DISORDERS%WIKIPATHWAYS_20260710%WP4583%HOMO SAPIENS Biomarkers for urea cycle disorders ARG1 HEL-S-20 GPT OTC NAGS GLS2 ASS1 ASL F7 F10 B CELL RECEPTOR SIGNALING%WIKIPATHWAYS_20260710%WP23%HOMO SAPIENS B cell receptor signaling NFKBIA PTPRC GRB2 FOXO1 FYN PRKCB NCK1 NFATC2 LCK BLK GTF2I HCLS1 NFATC3 ATF2 CD81 CAMK2A LAT2 DAPP1 CD79B MAPK8 PTPN18 TEC MAP2K6 SYK PIP5K1A JUN VAV1 MAPK14 PTPN6 BASH CBL CD79A MYC MAP3K7 CD22 PTPN11 PIK3AP1 GAB2 MAX PIP5K1C MAPK9 RPS6KA1 INPP5D CR2 GSK3B PLCG1 RAC1 BTK NFKB1 HRAS PIK3R1 BCL6 MAP2K1 PLCG2 MAP2K2 BCL10 CRKL PDPK1 CREB1 CHUK IKBKB VAV2 RAPGEF1 CARD11 STM7 IKBKG SOS1 RAF1 CRK SHC1 CD19 PIK3R2 MAP4K1 GSK3A RELA LYN MAPK4 RASGRP3 REL CDC42 MAPK1 UROTENSIN II MEDIATED SIGNALING%WIKIPATHWAYS_20260710%WP5158%HOMO SAPIENS Urotensin II mediated signaling HMOX1 COL1A1 CDK2 MAPK3 ABCA1 VCAM1 NCF1 NCF2 NCF4 IRF3 CASP9 CASP3 NPPB CYBA ARHA NPPA CAMK2A STAT3 EGFR PLN CREBBP MAPK8 CDC2 TRPC4 AGTR1 MMP2 ESPL1 NOX4 MAPK14 HDAC5 IL6 PTPN11 BCL2 CYBB BAX MAPK9 TNF SMAD2 GSK3B EP300 PTEN IL1B UTS2R COL3A1 NFKB1 DDIT3 AIFM2 PCNA CHUK IKBKB CCNE1 UTS2 TGFB1 HSPA2 ACTA2 GSK3A RELA COL2A1 MMP9 ALOX5 MAPK1 DRAVET SYNDROME%WIKIPATHWAYS_20260710%WP5200%HOMO SAPIENS Dravet syndrome SCN1A MLST8 TNF PRKCA MTOR SCN8A SCN2A PRR5 SCN4B NFKB1 CALM1 CAMK2A FGF13 HCN1 MAPKAP1 SNTA1 KCNA2 PCDH19 RICTOR SCN3B SCN3A PIK3CA SCN1B SCN2B CHD2 STXBP1 MAPK11 NRXN1 DELETION SYNDROME%WIKIPATHWAYS_20260710%WP5398%HOMO SAPIENS NRXN1 deletion syndrome GRIA3 NLGN3 GRIA4 NLGN2 GRIN2B GRIN1 GRIN3B NRXN1 NLGN1 GRIN3A GRIA2 DLG4 CHROMOSOMAL AND MICROSATELLITE INSTABILITY IN COLORECTAL CANCER %WIKIPATHWAYS_20260710%WP4216%HOMO SAPIENS Chromosomal and microsatellite instability in colorectal cancer MAPK10 MAPK3 TBK1 PTGS2 BIRC5 CASP9 CSNK1A1 MSH2 CASP3 CYCS ARHA CDKN1A MAPK8 GADD45B BCL2L11 GADD45G BAK1 APPL1 DCC JUN BBC3 FOS MYC AXIN1 DDB2 BCL2 POLK LEF1 BAX TGFBR1 RALA TGFBR2 MAPK9 PMAIP1 NTN1 ARAF APC2 SMAD2 TCF7L2 CSNK1A1L TCF7L1 SMAD4 CCND1 GSK3B AKT3 GADD45A RAC1 BAD RAC3 MSH3 MSH6 APC MAP2K1 RAF1 TGFB1 EXOC2 AXIN2 RALB REL MAPK1 RAC1 PAK1 P38 MMP2 PATHWAY%WIKIPATHWAYS_20260710%WP3303%HOMO SAPIENS RAC1 PAK1 p38 MMP2 pathway NFKBIA MAPK3 GRB2 FOXO1 NCK1 BIRC5 CASP9 MSH2 STAT3 EGFR MAPK8 GRB14 RS1 ANGPTL1 GRB7 TNIP2 TNIP3 MMP2 ANGPT1 MAPK14 MAPK12 ANGPT4 ANGPT2 MAPK13 MYC MAPK11 YAP1 STAT5B PTPN11 BAX MAPK9 ERBB2 RAD51 RAC1 BAD NFKB1 HRAS PIK3R1 NRAS EIF4EBP1 NOS2 CHUK IKBKB IKBKG SOS1 PIK3CA CRK SRC PXN ITGB1 RELA PAK1 MAPK1 TGIF DISRUPTION OF SHH SIGNALING%WIKIPATHWAYS_20260710%WP3674%HOMO SAPIENS Tgif disruption of Shh signaling SHH NODAL FGF8 FOXG1 NKX2-1 GLI3 TGIF1 SMAD2 TGIF2 TROP2 REGULATORY SIGNALING%WIKIPATHWAYS_20260710%WP5300%HOMO SAPIENS TROP2 regulatory signaling BCL2 BAX CDK2 IGF2R PSEN2 PECAM1 PRKCA CHEK1 STAT1 ACVRL1 CCND1 RAC1 PTEN ABCC1 NFKB1 PIK3R1 RB1 EGFR CDK4 IGF1R CCNE1 TLN1 NOTCH1 CDKN1B TACSTD2 JUN MDK CDKN2A SRC CLDN7 ITGB1 HEL113 IGF2 CLDN1 PAK4 IGF1 GLUCOCORTICOID RECEPTOR PATHWAY%WIKIPATHWAYS_20260710%WP2880%HOMO SAPIENS Glucocorticoid receptor pathway RGS2 DNAJC15 THBD ARL5B SRGN NAV3 STOM ADGRF4 PRRG4 SNAI2 PPP1R14C ANKRD1 PTGS2 BIRC3 ALOX5AP IL11 B3GNT5 GADD45B JUN BHLHB2 MFGE8 MGAM ZIC2 POU5F1 TGFBR3 NR1i2 CDKN1C PDE4B NR3C1 BIRC2 SLC19A2 S100P FGD4 ANGPTL4 NFKB2 TNFAIP3 CCL2 NR1I3 CCL20 TNS4 RXRA PLK2 CPEB4 EPB41L4B DNER ENC1 FGFBP1 EDN2 TSC22D3 CDC42EP3 AMIGO2 PMP2 GPR153 SERTAD2 CAVIN2 SPRY1 PTGES3 ACKR3 SCNN1A SLC26A2 ABHD2 DISORDERS OF GALACTOSE METABOLISM %WIKIPATHWAYS_20260710%WP5173%HOMO SAPIENS Disorders of galactose metabolism SLC2A2 GYS1 HEL-S-19 SLC5A1 GYG1 AKR1B1 PYGL GYS2 VITAMINS A AND D ACTION MECHANISMS%WIKIPATHWAYS_20260710%WP4342%HOMO SAPIENS Vitamins A and D action mechanisms NR1i1 RXRA RARA PKC GAMMA CALCIUM SIGNALING IN ATAXIA%WIKIPATHWAYS_20260710%WP4760%HOMO SAPIENS PKC gamma calcium signaling in ataxia GRIA3 GRIA4 GNA11 ATP2B2 RYR3 CACNA1A GNA15 PLCB3 PLCB4 HOMER3 GNA14 CA8 PLCB1 PLCB2 GRIA2 TRPC3 THYMIC STROMAL LYMPHOPOIETIN TSLP SIGNALING%WIKIPATHWAYS_20260710%WP2203%HOMO SAPIENS Thymic stromal lymphopoietin TSLP signaling NFKBIA GAB2 STAT4 FES MAPK9 TSLP MAPK3 FYN LCK STAT1 YES1 RPS6 BTK NFKB1 NFKB2 IL7R MAP2K1 STAT3 MAP2K2 EIF4EBP1 MAPK8 TEC SRC MAPK14 RELA CRLF2 RELB LYN JAK1 STAT5B MAPK1 PTPN11 FEMALE STEROID HORMONES IN CARDIOMYOCYTE ENERGY METABOLISM%WIKIPATHWAYS_20260710%WP5318%HOMO SAPIENS Female steroid hormones in cardiomyocyte energy metabolism PPARGC1B APOB ACLY STK11 MTTP ESRRA HADHB SLC2A4 NR1C1 ACADM AMPLIFICATION AND EXPANSION OF ONCOGENIC PATHWAYS AS METASTATIC TRAITS%WIKIPATHWAYS_20260710%WP3678%HOMO SAPIENS Amplification and expansion of oncogenic pathways as metastatic traits TCF7L1 VEGFA SRC LEF1 TNC CXCR4 POSTN VCAM1 CYTIP NOTCH1 TCF7L2 VHL GLIAL CELL DIFFERENTIATION%WIKIPATHWAYS_20260710%WP2276%HOMO SAPIENS Glial cell differentiation GAP43 CNP HEL70 MBP FREP1 AMINO ACID TRANSPORT DEFECTS IEMS %WIKIPATHWAYS_20260710%WP5029%HOMO SAPIENS Amino acid transport defects IEMs SLC6A20 SLC6A19 SLC3A2 SLC7A7 SLC36A2 CLTRN SLC7A9 SLC1A1 SLC3A1 SPINA BIFIDA%WIKIPATHWAYS_20260710%WP5150%HOMO SAPIENS Spina bifida MTR MAT1A SHMT1 MTHFD1 AHCYL2 MTRR DNMT3B MTHFR DEFICIENCY%WIKIPATHWAYS_20260710%WP4288%HOMO SAPIENS MTHFR deficiency MARS1 ASMT GRIN1 ALDH7A1 HEL-S-61p CASP9 EHMT1 CASP3 CYCS PEMT CHPT1 CHDH CHKA DNMT3B MODULATION OF PI3K AKT MTOR SIGNALING BY BIOACTIVE SPHINGOLIPIDS%WIKIPATHWAYS_20260710%WP5192%HOMO SAPIENS Modulation of PI3K Akt mTOR signaling by bioactive sphingolipids MTOR S1PR1 SPHK2 IGF1R S1PR3 HIF1A CERK LASS1 TSC1 NFKB1 PIK3CA ASAH2 NAD BIOSYNTHETIC PATHWAYS%WIKIPATHWAYS_20260710%WP3645%HOMO SAPIENS NAD biosynthetic pathways TNKS2 SIRT7 NAPRT SIRT4 BST1 NMNAT1 NADSYN1 TDO2 TNKS SIRT6 HEL-S-90n NAMPT IDO1 PARP4 PARP2 SIRT5 SIRT1 SIRT3 SIRT2 TYPE I INTERFERON INDUCTION AND SIGNALING DURING SARS COV 2 INFECTION%WIKIPATHWAYS_20260710%WP4868%HOMO SAPIENS Type I interferon induction and signaling during SARS CoV 2 infection TYK2 TREML4 OAS1 TBK1 IRF3 OAS2 STAT1 IRF9 IKBKE TRAF3 IFNAR2 TLR4 ACE2 EIF2AK2 IRAK4 STAT2 TMPRSS2 IRF7 TLR9 TLR7 TLR3 IFNAR1 IFIH1 OAS3 MAVS JAK1 TRAF6 MYD88 RIGI ENDOPLASMIC RETICULUM STRESS RESPONSE IN CORONAVIRUS INFECTION%WIKIPATHWAYS_20260710%WP4861%HOMO SAPIENS Endoplasmic reticulum stress response in coronavirus infection BCL2 PPP1R15B PPP1R13B PPP1R11 PPP1R14A PPP1R12C PPP1R3A PPP1R9A PPP1R2 PPP1R8 PPP1R14C sm-M20 PPP1R16B PPP1R14B PPP1R16A PPP1R3G PPP1R3F PPP1R1A PPP1R3C ATF4 PPP1R3B MAP1LC3A PPP1R3E PPP1R1C PPP1CC PPP1R3D PPP1R14D PPP1R15A HEL-S-80p MBTPS1 XBP1 EIF2S1 HEL-S-89n ERN1 DDIT3 PPP1R1B MBTPS2 MAPK8 EIF2AK2 PPP1R7 PPP1R10 EIF2AK1 PENTOSE PHOSPHATE PATHWAY IN SENESCENT CELLS%WIKIPATHWAYS_20260710%WP5043%HOMO SAPIENS Pentose phosphate pathway in senescent cells RPIA PRPS1L1 DERA HEL-S-304 RPE MAPK SIGNALING%WIKIPATHWAYS_20260710%WP382%HOMO SAPIENS MAPK signaling MAPK10 GRB2 JUND PTPN5 CD14 PRKCA ATF4 CACNA1H PPP3CA PPP3R1 PPP3R2 RASGRF1 NTRK1 RPS6KA5 SMIM40 MAPKAPK3 MAPKAPK2 MAP3K14 TAOK1 FGFR1 FLNB FGF8 MAX FGFR3 TGFBR1 TGFBR2 HEL-S-102 MEF2C TNF EGF FGF16 RAC1 MAPK8IP3 CACNA1G DUSP16 DUSP10 DUSP4 CACNA1C DUSP8 DDIT3 DUSP9 DUSP7 PPM1B NRAS FGF19 RAPGEF2 FGF21 TAOK3 CRKL NTRK2 pk RPS6KA4 FGFR4 NGF MAP3K7IP1 BDNF MAP3K8 MAP3K6 RAF1 MAP3K13 MAPK8IP2 MAP3K11 NF1 MAP3K12 HEL-S-31 GNG12 MAP4K1 STK4 MAP4K2 RELA CACNA2D1 CACNA2D3 RASGRP4 RELB CACNA2D2 CACNA2D4 RASGRP3 PAK1 CACNB1 MAP4K3 CACNB3 MAP3K2 CACNB4 DUSP2 RASGRF2 MAPK1 LAMTOR3 PLA2G4F CACNA1F NTF3 CACNG6 PLA2G4D CACNG7 CACNG8 MAPK3 PLA2G4E PLA2G4B FGF3 PLA2G4C DKFZp686L0365 RRAS2 FGF6 FGF9 IL1R2 CACNA1B CACNG1 CACNA1A CACNA1S CACNG2 RASA2 CACNG3 CACNG4 CACNG5 CDC25B LRRK2 FGF20 CASP3 FGF22 FGF17 PRKACG RRAS FGF14 FGF23 FGF18 NFATC3 ATF2 FGF13 EGFR FGF12 MAPK8 FGF7 MAPKAPK5 IL1A MAP3K5 MAP2K6 MAP2K3 MAP2K4 JUN TRAF2 FOS MAPK14 MAPK12 TNFRSF1A MAPK13 MYC HEL-S-72p MAPK11 MAP3K7 FLNA PDGFA TNFSF6 FGF4 NFATC1 TRAF6 NTF4 SOS2 NLK PPP5C FGF10 MAPK9 CACNA1I ARAF IL1R1 MAP3K1 AKT3 GADD45A IL1B RAC3 FGF2 NFKB1 NFKB2 HRAS MAP2K1 PPP3CC MAP2K2 ECSIT CHUK FGFR2 IKBKB IKBKG SOS1 CRK TGFB1 HSPA2 RAP1A MAPK7 MAPK8IP1 HSPA1A MAP2K5 TAOK2 DUSP3 CDC42 INTERFERON TYPE I SIGNALING%WIKIPATHWAYS_20260710%WP585%HOMO SAPIENS Interferon type I signaling PTPRC MLST8 FYN ZAP70 LCK MTOR IRF9 RPS6KB1 EIF4E RPS6KA5 IFNAR2 STAT3 MAPKAP1 STAT2 MAP2K6 MAP2K3 IFNAR1 IRS1 VAV1 MAPK14 PTPN6 CBL SOCS3 SOCS1 JAK1 PTPN11 TYK2 GAB2 STAT4 RPTOR STAT1 MAP3K1 RAC1 PIK3CD RPS6 PRMT1 PIK3R1 EIF4EBP1 CRKL CREB1 RPS6KA4 PIAS1 RAPGEF1 CRK PIK3R2 RAP1A EIF4A1 REL EIF4B TRANSCRIPTION FACTORS REGULATE MIRNAS RELATED TO CARDIAC HYPERTROPHY%WIKIPATHWAYS_20260710%WP1559%HOMO SAPIENS Transcription factors regulate miRNAs related to cardiac hypertrophy MYEF2 PPP3R1 RASGRF1 NFKB1 TGFB1 STAT3 COVID 19 THROMBOSIS AND ANTICOAGULATION%WIKIPATHWAYS_20260710%WP4927%HOMO SAPIENS COVID 19 thrombosis and anticoagulation HEL-S-78p F13A1 PLG FGA F2 F13B MALE STEROID HORMONES IN CARDIOMYOCYTE ENERGY METABOLISM%WIKIPATHWAYS_20260710%WP5320%HOMO SAPIENS Male steroid hormones in cardiomyocyte energy metabolism HSD17B3 CYP11A1 HSD17B2 HSD3B1 HSD3B2 SRD5A2 CYP17A1 SULT1A1 UGT1A1 PROTEOGLYCAN BIOSYNTHESIS%WIKIPATHWAYS_20260710%WP4784%HOMO SAPIENS Proteoglycan biosynthesis SLC35B2 XYLT2 CANT1 CHST3 PAPSS2 CHSY1 BPNT2 CSGALNACT1 B3GAT3 XYLT1 B3GALT6 EXT1 EXT2 CHST14 SLC26A2 GLYCOSAMINOGLYCAN DEGRADATION%WIKIPATHWAYS_20260710%WP4815%HOMO SAPIENS Glycosaminoglycan degradation HGSNAT HPSE2 IDUA GNS SGSH GALNS HYAL2 HYAL4 HPSE GUSB HEL-S-111 HEXA GLB1 MIR TARGETED GENES IN LEUKOCYTES%WIKIPATHWAYS_20260710%WP2003%HOMO SAPIENS miR targeted genes in leukocytes TUBA1A YWHAQ SLC25A1 FADS1 PTPA HEL-S-30 PRPF40A VPS39 PLXND1 RDH10 RFT1 GNA13 POLR2C MPDU1 TMED10 SPTLC1 TNLG5A CHORDC1 THBS1 CDK5RAP3 SFXN1 PPIF ATP6V0E1 IFRD1 MRPL20 PNP SNX6 PISD KCNN4 TRAM1 MRC2 MAP3K8 HEL-S-66 TMED3 CTSC SLC7A6 CDCP1 ATP2A2 TPM3 FRG1 SERPINE2 GOLGA7 GYS1 SAC3D1 ATP6V1F MENT ADPGK PRSS21 PTRH1 CA12 LPL UNC93B1 ARCN1 WDR11 ARF4 ANXA2 HMOX1 LAMTOR3 TUSC2 ARID4B SH3BGRL3 DCAF7 PPIB SHOC2 SLC1A4 ADIPOR2 CORO1C ANAPC1 CD164 BRPF3 DDX5 HMGA1 HEL-S-26 SNAP23 CEBPB TNFAIP2 LMNB2 TMEM109 NELFCD ACP2 SCYL1 ARHG MCL1 DNAJB1 TBCA MAPK14 FMNL2 BCL2 POLE4 CAP1 PHC2 IGF2R TMEM43 SRSF10 TXN2 BCL6 CDK6 USP1 RTN4 AP3D1 CDIPT ADAR TYMS POM121 RAB5C MTHFD2 HEL-S-47e SLC7A11 PHOSPHODIESTERASES IN NEURONAL FUNCTION%WIKIPATHWAYS_20260710%WP4222%HOMO SAPIENS Phosphodiesterases in neuronal function PDE2A GUCY1A2 PDE10A PDE3B PDE12 PDE3A PDE5A PDE9A GUCY1B1 PDE4B PDE4A PDE4D PDE1C PDE1B ADCY9 ADORA2A DRD2 PDE7B PDE7A DRD1 CHRNA7 PDE1A CAMK2A PPP1R1B CREB1 GRIN2B GRIN1 PDE8A ADCY3 ADCY1 ADCY8 PRKG1 ADCY6 ADCY5 HEL-S-7a PDE11A PDE6D PDE6C PDE6A PDE6H PDE6G PROTEASOME DEGRADATION%WIKIPATHWAYS_20260710%WP183%HOMO SAPIENS Proteasome degradation PSMD1 HLA-B PSMB9 PSMA4 PSMD10 PSMA2 UBA7 UBE2D2 UBE2D3 UBE2D1 PSMB6 PSMB10 PSMD7 PSMB2 PSMD5 PSMB3 UBE2B PSMC1 HEL-S-283 HEL-S-276 PSME2 PSMC6 PSMC4 PSMB8 PSMD12 PSMD2 PSMD13 H2AZ1 HLA-A HLA-F HLA-G HLA-E UBB UBC PSMD11 HLA-C H2AX RPN2 RPN1 HEL-S-91n HEL-117 NEDD4 PSMD9 PSMD6 IFNG PSMD4 HIST1H2AB PSMD3 SELENIUM MICRONUTRIENT NETWORK%WIKIPATHWAYS_20260710%WP15%HOMO SAPIENS Selenium micronutrient network HEL-S-44 APOB ABCA1 FGA PTGS2 ALOX15B GPX2 PTGS1 HEL-S-97n KYNU GPX4 FLAD1 PRDX3 GPX3 KMO PRDX5 CRP GPX1 HEL-75 ALOX5AP HEL-S-78p SAA4 PLAT MPO HBA2 F2 HEL-S-2a HBB DIO1 CBS IL6 XDH IFNG HEL-S-302 TNF CTH SAA1 SAA2 TXNRD2 IL1B INSR NFKB1 INS NFKB2 SCARB1 SELENOF TXN SELENOK SELENOI F7 SELENOH CCL2 SEPHS2 SELENOO SELENOP SELENON PLG SELENOM LDLR SELENOW SELENOV SELENOT MSRB1 SELS MTR RELA GPX6 ALB ALOX5 FIBRIN COMPLEMENT RECEPTOR 3 SIGNALING%WIKIPATHWAYS_20260710%WP4136%HOMO SAPIENS Fibrin complement receptor 3 signaling CXCL3 LBP IFNB1 ITGAM FGA CD14 TNF IRF3 TICAM2 TICAM1 ARHA IRAK2 NFKB1 CCL2 TLR4 IL12B HEL-S-78p NOS2 CHUK IRAK4 PLAT IKBKB TIRAP PLG IKBKG TLR3 PIK3CA IRAK1 SYK SRC TYROBP RELA LY96 FCER1G IL6 REL TRAF6 MYD88 ALLOGRAFT REJECTION%WIKIPATHWAYS_20260710%WP2328%HOMO SAPIENS Allograft rejection VEGFA PECR CXCL9 TUBA1B C4A CASP9 CD40 LRRK2 CASP8 GNLY CXCL11 CASP3 HARS1 HLA-DOA HLA-DOB HLA-DRB5 HLA-A HLA-F HLA-G FOXP3 HLA-E IL1A CXCR5 AGTR1 HLA-DRB1 IL22 CCL19 HLA-DQA2 HLA-DQA1 PDGFRA HLA-C C8A HLA-DPA1 PRF1 HLA-DQB1 HLA-DMA HLA-DMB IL2 MICA TNFSF6 HLA-DPB1 IFNG HLA-B ABCB1 CCL21 GDNF TNF C1QB C1QA CD40LG C4B_2 STAT1 IL1B CXCL13 C1QC CXCL8 IL-21 PRKCZ IL12B IL13 CXCL12 IL10 C6 C7 IL4 GABPA C9 IL5 CD55 TGFB1 CD80 CSNK2A2 IL17A CTLA4 IL12A HEL-S-62p HEL113 IL2RA BHMT2 VITAMIN K METABOLISM AND ACTIVATION OF DEPENDENT PROTEINS%WIKIPATHWAYS_20260710%WP5186%HOMO SAPIENS Vitamin K metabolism and activation of dependent proteins F9 PROC VKORC1 NQO1 UBIAD1 GGCX PROZ PROS1 F2 F7 F10 AIFM2 JOUBERT SYNDROME%WIKIPATHWAYS_20260710%WP4656%HOMO SAPIENS Joubert syndrome CEP97 TTC8 AHI-1 ATF4 MTOR OFD1 KAT5 ARHA CEP164 CCP110 ARR3 TCTN3 TCTN2 TCTN1 CC2D2A ARMC9 TMEM138 RP2 TMEM216 CEP104 ARL3 ARL2 BBS2 ARL13B NEK8 TMEM67 INPP5E BBS1 PCNT PIBF1 RAB3IP CPLANE1 TMEM231 TMEM17 CETN2 TMEM237 UNC119 B9D1 CEP41 B9D2 FLNA MKS1 SHH DVL1 DVL3 ZNF423 BBS9 RAD50 SUFU NPHP3 BBS7 MRE11A CEP290 BBS5 RAB8A PCM1 BBS4 ATM RHEB INVS NPHP1 RPGRIP1L MYO6 PDE6D PDE6A PDE6G RIBOFLAVIN AND COQ DISORDERS%WIKIPATHWAYS_20260710%WP5037%HOMO SAPIENS Riboflavin and CoQ disorders SLC52A2 SLC52A1 COQ6 PDSS1 ETFA COQ8A COQ9 COQ7 APTX COQ2 FLAD1 SILDENAFIL TREATMENT%WIKIPATHWAYS_20260710%WP5294%HOMO SAPIENS Sildenafil treatment GUCY1A2 NOS2 PDE5A GUCY1B1 PARK2 PDE4B PDE4A PPARGC1A PDE4D PRKG1 GSK3B AKT3 NRF1 ZNF746 HEL-S-162eP TFAM EGF EGFR SIGNALING%WIKIPATHWAYS_20260710%WP437%HOMO SAPIENS EGF EGFR signaling CAV2 MEF2D GRB2 JUND FOXO1 NCK2 FOSB PTPN5 NDUFA13 NCK1 PRKCA RAB5A PTK6 RPS6KA5 STAT3 RICTOR IQGAP1 PTK2B HEL-S-15 VAV1 ARHGEF1 STXBP1 JAK1 NEDD4 AP2S1 HEL-S-34 RALBP1 RALA PLD2 AP2M1 MEF2C INPP5D EGF STAT1 COX2 PLCG1 RAC1 PTEN PIK3R1 ATF1 EIF4EBP1 CBLC CRKL CREB1 RPS6KA2 RAF1 SH2D2A GJA1 RIN1 PXDN SH3GL2 MAP4K1 PAK1 MAP3K2 MAPK1 PRKCB AP2A1 ARF6 MTOR RPS6KB1 GRB10 CAMK2A EGFR MAPK8 HGS JUN FOS PIK3C2B MAPK14 CBL USP6NL INPPL1 STAMBP STAT5B STAM2 PTPN11 ATXN2 SOS2 GAB2 EPS15L1 PLSCR1 EPN1 ASAP1 NEDD8 MAPK9 ERBB2 REPS2 LIMK2 ITCH RPS6KA1 MAP3K1 TNK2 PRKCI SH3GL3 FOXO4 HRAS PRKCZ VAV3 MAP2K1 MAP2K2 PDPK1 PCNA SPRY2 SP1 VAV2 SOS1 CRK SHC1 SRC PIK3R2 SYNJ1 RAP1A ROCK1 MAPK7 RALB PLCE1 CSK MAPK4 MAP2K5 CDC42 SOLUBLE ACE2 MEDIATED CELL ENTRY OF SARS COV 2%WIKIPATHWAYS_20260710%WP5076%HOMO SAPIENS Soluble ACE2 mediated cell entry of SARS CoV 2 ACE2 AGTR1 AVPR1B ADAM17 IL26 SIGNALING%WIKIPATHWAYS_20260710%WP5347%HOMO SAPIENS IL26 signaling TYK2 NFKBIA RORC BAX MAPK9 MAPK3 IL33 DCSTAMP DEFB4B ATP6V0D2 TNF SMAD2 STAT1 COX2 CASP3 IL26 IL1B CXCL8 DDIT3 EPHA3 CTSK STAT3 MAPK8 IL10RB CCL20 TNFSF11 MPO IL10 PIK3CA CSF2 JUN IL17A MAPK14 ACTA2 RELA SOCS3 JAK1 IL6 NFATC1 IL20RA MAPK1 MMP9 MYD88 DISTINCT INPUT OUTPUT PATHWAY%WIKIPATHWAYS_20260710%WP3877%HOMO SAPIENS MYD88 distinct input output pathway IL1A TLR1 TLR9 TLR7 TLR8 TLR10 IRAK1 JUN TIFA HEL-S-71 NFKB1 TLR5 TRAF6 MYD88 UBE2V1 TLR4 WNT BETA CATENIN SIGNALING AND ARTD FAMILY MEMBERS%WIKIPATHWAYS_20260710%WP5529%HOMO SAPIENS Wnt Beta catenin signaling and ARTD family members SKP1 PLK1 TNK1 TNK2 DVL1 BTRC DVL2 DVL3 PARP10 APC AXIN1 RBX1 PATHWAYS AFFECTED IN ADENOID CYSTIC CARCINOMA%WIKIPATHWAYS_20260710%WP3651%HOMO SAPIENS Pathways affected in adenoid cystic carcinoma ARID4B CHEK2 CHEK1 SRCAP PRKDC BRCA1 TLK1 CREBBP BCORL1 KDM6B UHRF1 NOTCH1 FBXW7 CEBPA SETD2 MYC FOXO3A MAX ERBB2 SMARCE1 BCOR JMJD1C HIST1H1E MYBL1 CMTR2 MAGI1 HIST1H2AK NCOR1 INSRR FOXP2 EP300 MORF4L1 KAT6A FGF16 PTEN MYCBP MGA MYB ERBIN KANSL1 NFIB HRAS ARID5B SMC1A DTX4 MAP2K2 ATM MAML3 FGFR4 KMT2C CTBP1 RAF1 ARID1A PIK3CA 1P36 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260710%WP5345%HOMO SAPIENS 1p36 copy number variation syndrome OR4F5 VEGFA OR4F3 CDK11A CFAP74 MIB2 PEX10 IFIT1 PEX12 RNF223 MORN1 TMEM278 FNDC10 ANKRD65 VTN INTS9 GRIK2 SLC35E2B C1orf159 ARF6 AGRN DKK3 UBE2J2 ELAVL1 TRIM25 INTS4 CD160 B3GALT6 COMMD1 IFIH1 TRAF2 MCM2 HEL-S-72p BTLA RBX1 TRAF5 TNFRSF4 DVL1 PLCH2 TNLG2B SMAD2 SMAD4 TNFRSF14 SKI MRPL20 PANK4 INTS11 INTS13 PRKCZ INTS14 INTS10 GDE1 ISG15 TMEM52 TNFRSF18 NOC2L METTL14 SDF4 PLEKHN1 CCNL2 C1QTNF12 SAMD11 CALML6 MUSK GNB1 SSU72 PEX2 ATAD3A PHKG2 ATAD3C GLTPD1 ACAP3 TGFB1 RER1 SCNN1D MMP23B PEX5 MXRA8 VWA1 AURKAIP1 TNLG2A PERM1 KLHL17 MEPCE LRP4 PARD6B PUSL1 TAS1R3 HES5 NADK HES4 MECP2 AND ASSOCIATED RETT SYNDROME%WIKIPATHWAYS_20260710%WP3584%HOMO SAPIENS MECP2 and associated Rett syndrome GRIA3 GRIA4 SMC3 FGF3 OPRK1 PSIP1 CTCF MTOR REST RBFOX1 TET3 DLX6 NREP PRPF38A HDAC1 POU4F1 POU3F2 HNRNPF HNRNPH1 CEBPD CAMK2A YBX1 HEL-S-20 IGF1R CDON GAD1 FUT8 GPRIN1 FOXG1 FGF4 SST IGF1 TET1 SP3 MEF2C CNP NCOR1 TARDBP PTEN RPS6 TAF1 FGF2 UBE3A BCL6 CREB1 MYT1 BDNF SP1 FKBP5 GRIN1 NF1 IGF2 EZH2 DLX5 MBP FUS SIN3A TET2 SGK1 APOC2 HEME BIOSYNTHESIS%WIKIPATHWAYS_20260710%WP561%HOMO SAPIENS Heme biosynthesis ALAS1 HMBS CPOX ALAS2 FECH UROD UROS METABOLISM OF ALPHA LINOLENIC ACID%WIKIPATHWAYS_20260710%WP4586%HOMO SAPIENS Metabolism of alpha linolenic acid ALOX15 ALOX12 PTGS2 FADS2 FADS1 ALOX5 ACRYLAMIDE BIOTRANSFORMATION AND EXPOSURE BIOMARKERS%WIKIPATHWAYS_20260710%WP4233%HOMO SAPIENS Acrylamide biotransformation and exposure biomarkers CYP2E1 CYTOPLASMIC RIBOSOMAL PROTEINS%WIKIPATHWAYS_20260710%WP477%HOMO SAPIENS Cytoplasmic ribosomal proteins RPS6KB2 RPLP2 RPS6KB1 RPS27A HEL-S-310 RPL4 RPL3 RPL32 RPL38 RPL31 RPLP1 RPL10A RPL34 RPLP0 RPL8 RPL9 RPL6 RPS15 RPS4X RPS14 RPL7A RPL11 RPS17 RPS16 RPS19 RPS18 RPL36 RPL35 RPL37 RPL39 RPS10 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL13a RPL22 RPS3A RPSA RPL37A RPL29 RPL28 RPL10 RPL12 MRPL19 RPL36A RPS4Y1 RPS15A RPL14 RPS3 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPS6KA1 RPL41 RPL35A RPL23A RPL3L RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU RPS6 RPS21 RPL5 RPS24 RPL30 RPS23 RPL7 RPL18A RPS11 RPS6KA6 RPS6KA2 RPL27 RPL26 TRANSCRIPTIONAL REGULATION OF MEMORY B CELL DIFFERENTIATION%WIKIPATHWAYS_20260710%WP5491%HOMO SAPIENS Transcriptional regulation of memory B cell differentiation BCL2L1 IRF4 MEF2C IRF8 TLR10 CD40 TCF4 TNFRSF13C MEF2B NFKB1 SPIB POU2AF1 TLR5 BCL6 STAT3 TLR4 CDKN1A CD79B TLR1 TLR9 TLR7 TLR8 TLR3 SYK CDKN1B CDKN2A TCF3 IL21R ID3 BCR CCND3 CCND2 EZH2 CD79A MYC LYN POU2F2 IL6 SPI1 DRUG INDUCTION OF BILE ACID PATHWAY%WIKIPATHWAYS_20260710%WP2289%HOMO SAPIENS Drug induction of bile acid pathway SLC51A NR1i1 NR1I3 SLC51B NR1H4 ABCB1 ABCB11 NR1i2 CYP3A4 SLCO1B1 CYP7A1 BAAT SULT2A1 ABCC3 ABCC2 REGULATION OF CYTOTOXIC T CELL RESPONSES BY MALAT1 MIR 15 16 CIRCUIT %WIKIPATHWAYS_20260710%WP5489%HOMO SAPIENS Regulation of cytotoxic T cell responses by Malat1 miR 15 16 circuit BCL2 CD3E SPN IL2 CD3D CD27 CD3G CD80 CANCER PATHWAYS%WIKIPATHWAYS_20260710%WP5434%HOMO SAPIENS Cancer pathways TPR COL4A4 COL4A3 COL4A5 LAMA5 LRP6 PRKCA LAMB2 ARHA EDN1 CAMK2D FZD2 FLT4 F2 VHL Em:AP000351.3 FGFR1 KIT FGFR3 MGST3 EGLN1 MGST1 GSTT2 MGST2 RAD51 BRCA2 FZD9 LAMA4 WNT9B LAMC1 FZD10 COL4A2 WNT9A COL4A1 GSTM4 GSTM3 GSTM2 WNT8B GSTM1 FH NOS2 EDNRA EDNRB TPM3 GSTM5 RPS6KB2 EML4 HEL-S-21 MSH2 HEL-S-22 CTBP2 PTGER4 PTGER1 PTGER2 PTGER3 BCR GSTA5 GSTA4 GSTA3 ITGA2B ARAF HHIP SUFU AKT3 PTCH2 KIF7 RAC3 ITGAV HRAS MAP2K1 MAP2K2 ITGA2 ITGA6 SOS1 CRK PIK3R2 RALB IL7 MAPK10 GRB2 RUNX1 BIRC7 BIRC5 NTRK1 ADCY3 ADCY1 ADCY8 ADCY6 ADCY5 GNA13 EGLN3 ARHGEF1 SPI1 GSK3B PTEN PIK3CD PIK3R3 NOTCH3 NOTCH4 DLL4 PIK3R1 NRAS KITLG CRKL KLK3 PIK3CA CTNNA1 ELOC CTNNA3 CTNNA2 JUP HDAC2 IFNA5 IFNA4 IFNA7 ARNT2 HDAC1 IFNA6 IFNA1 IFNA2 PML IFNA8 IFNA21 IFNAR2 IFNA13 CREBBP IFNA14 IFNA16 CCDC42 IFNGR1 STAT2 IFNA17 IFNGR2 IFNA10 IFNAR1 WNT2B CDKN1B PTCH1 BBC3 FRAT1 CCND3 CCND2 MYC ALK PDGFA WNT5B DDB2 AXIN1 RBX1 WNT16 SHH SOS2 FLT3LG LEF1 MAPK9 ERBB2 DVL1 DVL2 DVL3 PMAIP1 WNT1 WNT3 EGLN2 WNT4 WNT10B MMP3 TCF7L2 TERT WNT10A BIRC2 TCF7L1 SMAD4 BAD WNT3A WNT7B WNT7A NFKB1 NFKB2 APC MDM2 CHUK GNGT1 IKBKB SP1 GNB1 GNAS IKBKG HEL-S-125m PIM1 PIM2 NFKBIA FOXO1 FZD1 FZD7 FZD8 JAG2 LPAR1 IGF1R DLL3 APPL1 DCC RET GLI3 MAX GNAI3 CXCR4 SMO RARA RARB GNAI1 PLCG1 FGFR4 FLT3 KPG_010 TGFA LPAR2 LPAR3 LPAR4 GNG10 IGF2 GNG12 GNG11 GNG13 GNGT2 COL4A6 CASP9 CASP8 CASP3 CYCS FADD BIRC3 GNB2 GNB4 GNB3 CAMK2A GNB5 HSP90AB1 CAMK2G LAMC2 GNA11 LAMA1 LAMA3 NOTCH1 GNG3 LRP5 GNG2 GNG5 GNG4 GNG7 GNG8 LAMB3 LAMB4 LAMB1 IGF1 BMP4 STAT4 IL6R NCOA1 IL3 BMP2 IL6ST IL12RB1 NQO1 TXNRD2 MSH6 PLCG2 PPARG CDKN2B CDK6 CDK4 FGFR2 HEY2 CTBP1 AXIN2 NOTCH2 WNT8A HES1 CCDC6 IL15RA HES5 FZD3 PTGS2 RPS6KA5 STAT3 RXRB NR1C2 RXRG JAK1 CSF3R EPO IL5RA POLK RALBP1 TGFBR1 RALA PLD2 TGFBR2 IL13RA1 KEAP1 CSF1R SMAD2 CSF2RB CSF2RA EGF STAT1 CCND1 EP300 RAC1 RUNX1T1 ZBTB16 IL7R TFG DAPK2 EVI1 NKX3-1 PLEKHG5 TRAF4 CKS1B IL3RA ARHGEF11 CCNE1 ARHGEF12 CALML6 CALML3 CALML4 RAF1 RASSF1 HIF1A IL2RA IL2RB RELA RASGRP4 RASGRP3 HGF F2R MAPK1 HMOX1 VEGFA CCNE2 CDK2 F2RL3 MAPK3 PRKCB SKP2 EPOR MTOR SKP1 PLCB3 PLCB4 ADCY9 RPS6KB1 PRKACG PLCB1 PLCB2 NFE2L2 RB1 CDKN1A EGFR GADD45B MAPK8 KNG1 BCL2L11 GADD45G BDKRB2 AGTR1 BAK1 BDKRB1 FZD5 FZD4 PDGFRA JUN CDKN2A MMP2 TRAF2 FOS PAX8 CEBPA IL2 IL2RG CBL CCNA2 E2F2 E2F3 IL6 TNFSF6 JAK3 IFNG TRAF6 STAT5B TRAF5 BCL2 BAX BCL2L1 FRAT2 NR3A2 APC2 APAF1 GADD45A TRAF1 MSH3 TRAF3 CXCL8 IL12B IL13 VEGFB VEGFC VEGFD CXCL12 RXRA IL23A IL4 IL5 TGFB1 IL12A ITGB1 ROCK1 ROCK2 COMMON PATHWAYS UNDERLYING DRUG ADDICTION%WIKIPATHWAYS_20260710%WP2636%HOMO SAPIENS Common pathways underlying drug addiction GRIA3 GRIA4 GJB1 MAPK3 PS1TP5BP1 PRKCB ARAF GNAI1 PRKCA PPP1R1A PPP1CC HEL-S-80p PRKACG DRD2 CAMK4 DRD1 DRD4 CALM1 CAMK2A MAP2K1 MAP2K2 CREB1 GRIN1 ACTG2 GNAS ADCY1 RAF1 ADCY8 RAP1A GRIA2 ACTG1 MAPK1 22Q11 2 DISTAL CNV%WIKIPATHWAYS_20260710%WP5546%HOMO SAPIENS 22q11 2 distal CNV WDR57 SNRPB2 PTPA DHX16 SNRPA1 SF3B5 SF3B2 CD79B RPS15 RPS14 SF3A1 SF3A2 RPS17 RPS16 RPS19 PHF5A RPS18 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPSA NEDD4 RPS15A RPS3 RPS2 RPS26 XAB2 RPS28 RPS29 RPS20 XBP1 FAU RPS6 RPS21 RPS24 RPS23 UBE3A HEL-S-89n AQR RPS11 RNF19B UBE2L3 VPREB1 CWC22 CRNKL1 PDIA4 RAB36 PPIE SNRNP200 UBA6 CABP1 AK8 CWC15 PDIA2 TDRD3 GGTLC2 ZNF280A HEL-S-107 CCDC116 BUD31 PLRG1 YDJC HYOU1 RBM22 PAK1 PPM1F RNF113A RILP MAPK1 UGGT1 PPIL1 CDC5L IGLL5 YPEL1 PPIL4 PPIL6 ELOC GNAZ CHEK1 PPIB RPS27A CAMK4 SNW1 CAMK1 CAMK2A SDF2L1 CANX BCR CD79A CBL RBX1 IQUB ROPN1L RSPH6A DNAJB13 IGLL1 NME5 DYDC1 RSPH9 RSPH3 SNRPD2 SNRPD1 MDM2 RSPH14 SNRPD3 PARK2 SOX9 SNRPG ARIH1 SNRPE SNRPF SNRPB HEL-S-99n HEL-S-125m PRPF8 DNAJB11 LRP4 HFE EFFECT ON HEPCIDIN PRODUCTION%WIKIPATHWAYS_20260710%WP3924%HOMO SAPIENS Hfe effect on hepcidin production TMPRSS6 ID1 HFE HAMP BMP6 DISORDERS IN KETOLYSIS%WIKIPATHWAYS_20260710%WP5195%HOMO SAPIENS Disorders in ketolysis HMGCS1 BDH1 OXCT1 ACAT1 ACAT2 TNF RELATED WEAK INDUCER OF APOPTOSIS TWEAK SIGNALING%WIKIPATHWAYS_20260710%WP2036%HOMO SAPIENS TNF related weak inducer of apoptosis TWEAK signaling NFKBIA MAPK9 MAPK3 TNFSF12 TNF BIRC2 CASP8 GSK3B CASP3 RIPK1 RAC1 HDAC1 FADD TRAF1 TRIM63 BIRC3 TRAF3 NFKB1 NFKB2 TNFRSF12A MAPK8 CHUK IKBKB MAP3K14 RAF1 JUN TRAF2 MAPK14 NFKBIB RELA RELB MAP3K7 MAPK1 TRAF5 ENTEROCYTE CHOLESTEROL METABOLISM%WIKIPATHWAYS_20260710%WP5333%HOMO SAPIENS Enterocyte cholesterol metabolism APOB ABCA1 NPC1L1 FABP2 CD36 SLC27A4 MVK MSMO1 HSD17B7 ACAT2 TM7SF2 DKFZp434B2017 EBP ABCG8 PMVK ABCG5 SC5D LBR FDFT1 FDPS HMGCS1 HMGCR LDLR DHCR24 SQLE DGAT1 MVD DHCR7 MTTP CYP51A1 MGAT1 APOA4 AFLATOXIN B1 METABOLISM%WIKIPATHWAYS_20260710%WP699%HOMO SAPIENS Aflatoxin B1 metabolism GSTM1 CYP1A2 EPHX1 CYP3A4 HEL-S-166mP CYP2A13 MIRNA REGULATION OF P53 PATHWAY IN PROSTATE CANCER%WIKIPATHWAYS_20260710%WP3982%HOMO SAPIENS miRNA regulation of p53 pathway in prostate cancer TP53AIP1 MDM2 BAX ATM SESN3 EI24 SHISA5 CYS1 PMAIP1 ZMAT3 PERP CHEK2 CASP9 CASP8 APAF1 BBC3 CASP3 SIAH1 PTEN TNFRSF10B DDB2 LDLRAD4 INTRONIC SNP EFFECT ON COVID PATIENTS%WIKIPATHWAYS_20260710%WP4904%HOMO SAPIENS LDLRAD4 intronic SNP effect on COVID patients TGFBR1 TGFBR2 ATG16L1 NEDD4 TMEPAI SMAD2 DYRK1A INVOLVEMENT REGARDING CELL PROLIFERATION IN BRAIN DEVELOPMENT%WIKIPATHWAYS_20260710%WP5180%HOMO SAPIENS DYRK1A involvement regarding cell proliferation in brain development MLST8 FOXO1 DCAF7 LIN54 LIN52 AKT1S1 GMNN TFDP3 LIN37 MTOR REST CASP9 CSNK1A1 TFAP4 CASP3 RBBP4 EIF2B5 CRY2 H3F3B NOTCH1 RBL1 CDKN1B TFDP1 LATS2 TFDP2 E2F4 E2F5 NFATC1 NEUROG2 PSENEN BACE1 APP PSEN1 LIN9 RPTOR TSC2 CCND1 GSK3B RBL2 AMPH FGF2 TSC1 DEPTOR DYRK1A SIRT1 CREB1 CDK6 CDK4 SPRY2 DNER HES1 HES5 PATHWAYS OF NUCLEIC ACID METABOLISM AND INNATE IMMUNE SENSING%WIKIPATHWAYS_20260710%WP4705%HOMO SAPIENS Pathways of nucleic acid metabolism and innate immune sensing MITA OAS1 IFNB1 IRF3 RNASEH2C IFIH1 RNASEH2B ADAR RNASEH2A RNASET2 RNASEL CGAS MAVS TREX1 RIGI CILIOPATHIES%WIKIPATHWAYS_20260710%WP4803%HOMO SAPIENS Ciliopathies SPAG1 ALMS1 TTC8 KIAA0753 OFD1 XPNPEP3 CLUAP1 ADCY6 GLI3 SMO ZNF423 OCRL TULP1 PKD1 WDR35 NME7 GPR161 PDE6D DYNC2I2 TRAF3IP1 IFT172 CRX IFT80 AHI-1 LZTFL1 IFT81 ODAD1 ODAD3 ODAD4 CEP164 CCDC28B MCIDAS TBC1D32 INTU TCTN3 NEK1 TCTN2 NEK2 TCTN1 DNAAF3 CC2D2A CFAP418 HEL-S-296 DNAAF2 TMEM138 DNAAF6 RP2 CFAP410 TMEM216 FAM161A CEP104 WDPCP ARL3 CCNQ BBS2 CCNO NEK8 ARL13B ARL6 TMEM67 AK7 INPP5E BBS1 PKHD1 PIBF1 CEP78 PLK4 DCDC2 CPLANE1 TMEM231 DNAAF19 TMEM17 ARL2BP TMEM237 DRC1 UNC119 DNAL1 BBIP1 C2CD3 B9D1 DNAAF11 CEP41 FLCN B9D2 TMEM107 HYDIN CNGA1 CCDC39 DNAI2 CFAP52 TOPORS MKS1 ZIC2 RP1 BBS10 BBS12 IFT27 NME9 CCDC41 EFHC1 WDR51B PIK3R4 ZMYND10 KIZ CFAP53 CNGB1 SDCCAG8 KATNIP DNAH6 PKD1L1 CFAP298 DNAJB13 IFT52 RAB23 POC1A BBS9 RAB28 CENPF NPHP3 SUFU DNAI1 TUB BBS7 EVC2 DYX1C1 IFT57 USP9X PCARE CEP290 RSPH9 SCLT1 RPGRIP1 BBS5 KIF7 RP1L1 EVC TTLL5 RSPH3 HYLS1 IQCB1 ATXN10 RSPH1 TRIM32 IFT140 BBS4 IFT43 INVS NPHP1 RPGRIP1L CCDC40 DYNC2H1 NEK9 CEP19 ANKS3 DYNC2LI1 DYNLT2B DOCOSAHEXAENOIC ACID OXYLIPIN METABOLISM%WIKIPATHWAYS_20260710%WP5154%HOMO SAPIENS Docosahexaenoic acid oxylipin metabolism EPHX2 PTGS2 NICOTINE EFFECT ON CHROMAFFIN CELLS%WIKIPATHWAYS_20260710%WP1603%HOMO SAPIENS Nicotine effect on chromaffin cells CACNA1G CHRNB4 CHRNA3 CACNA1C SIGNAL TRANSDUCTION THROUGH IL1R%WIKIPATHWAYS_20260710%WP4496%HOMO SAPIENS Signal transduction through IL1R NFKBIA IFNB1 TNF IL1R1 MAP3K1 IFNA1 IL1B IRAK2 NFKB1 MAPK8 ECSIT CHUK IRAK3 MAP3K7IP1 IKBKB IL1A MAP3K14 MAP2K6 MAP2K3 IRAK1 TGFB1 JUN MAPK14 IL1RN RELA MAP3K7 IL6 TRAF6 MYD88 INTEGRATED CANCER PATHWAY%WIKIPATHWAYS_20260710%WP1971%HOMO SAPIENS Integrated cancer pathway BCL2 BAX CDK2 CHEK2 SMAD2 RAD50 CHEK1 STAT1 CASP9 MRE11A CASP8 CDC25B MSH2 CASP3 BAD PTEN BARD1 MSH6 BACH1 RB1 CDKN1A BRCA1 CDKN2B MDM2 ATF1 ATM CDC2 PLK1 CDK4 POU2F1 BLM ATR MAP3K5 NOXA1 CDKN1B BBC3 MYC JAK1 NRF2 ARE REGULATION%WIKIPATHWAYS_20260710%WP4357%HOMO SAPIENS NRF2 ARE regulation HMOX1 MAF MAPK8 KEAP1 FYN PIK3CA PRKCA SRC YES1 GSK3B PGAM5 NQO1 INSR AIMP2 GCLC GCLM EPHB2 NFE2L2 CEBPB SLC7A11 RBX1 MIR 517 RELATIONSHIP WITH ARCN1 AND USP1%WIKIPATHWAYS_20260710%WP3596%HOMO SAPIENS miR 517 relationship with ARCN1 and USP1 CDKN1A GIG8 ID1 USP1 ARCN1 NEPHROTOXCICITY ADVERSE OUTCOME PATHWAY%WIKIPATHWAYS_20260710%WP5229%HOMO SAPIENS Nephrotoxcicity adverse outcome pathway SLC31A1 SLC22A2 FGFR3 SIGNALING IN CHONDROCYTE PROLIFERATION AND TERMINAL DIFFERENTIATION%WIKIPATHWAYS_20260710%WP4767%HOMO SAPIENS FGFR3 signaling in chondrocyte proliferation and terminal differentiation BMP4 FGFR3 PTH1R MAPK3 BMP2 SNAI1 PTHLH FGF9 CNP STAT1 NPR2 FGF18 DKFZp686F0183 MAP2K1 CDKN1A MAP2K2 PPP2CA SOX9 RAF1 RBL1 THRA MAPK14 MAPK12 MAPK13 MAPK11 MAPK1 EXERCISE INDUCED CIRCADIAN REGULATION%WIKIPATHWAYS_20260710%WP410%HOMO SAPIENS Exercise induced circadian regulation PER1 PSMA4 PIGF TOB1 H2BC15 PPP1R3C SUMO1 HEL-S-22 UCP3 AAG1 KLF9 NCKAP1 CEBPB GSTM3 DAZAP2 BTG1 PER2 PURA STBD1 SUMO3 ERC2 CRY2 RBPMS ZFR G0S2 CLDN5 MYF6 CRY1 QK3 ETV6 VAPA CBX3 HLA-DMA HEL-S-72p NR1D2 DIFFERENTIATION OF WHITE AND BROWN ADIPOCYTE%WIKIPATHWAYS_20260710%WP2895%HOMO SAPIENS Differentiation of white and brown adipocyte PPARGC1B BMP4 DKFZp781O1323 BMP2 ZIC1 LEP CEBPG ZNF423 HSPB7 CIDEA PPARGC1A EBF3 HOXC9 HOXC8 MPZL2 DGIC CEBPA BMP7 SMAD1 PRDM16 SMAD9 CEBPB SLC7A10 PPARG FAMILIAL PARTIAL LIPODYSTROPHY%WIKIPATHWAYS_20260710%WP5102%HOMO SAPIENS Familial partial lipodystrophy MAPK9 LMNA HEL-S-104 KLF5 FNTA ICMT KLF2 INS KLF9 PPARG LMNB2 LIPE GATA3 PNPLA2 CIDEA PIK3CA ZMPSTE24 PRRX1 CIDEC BANF1 GATA2 CEBPA MGLL PLIN1 LPL NR1C1 STAT5B HDAC6 INTERACTIONS IN THE CENTRAL NERVOUS SYSTEM%WIKIPATHWAYS_20260710%WP5426%HOMO SAPIENS HDAC6 interactions in the central nervous system TUBA1C HEL-S-44 APOE MAP1B MAPK3 MYH9 CDC20 CSNK2B ELP3 TUBB HEL-S-32 BIRC5 TUBA4A ITIH4 KAT5 HSF1 TUBA2 EP400 TWIST1 EGFR MAPK8 DLG2 FOXP3 MAP3K5 HEL-S-2a VCP FREP1 PRKCE PTK2B VHL MAPRE1 BBIP1 HEL-S-72p HTT HEL-S-67p SIRT2 SHH BCL2 CYBB BAX POU5F1 HEL-S-102 AURKA DCTN1 SMAD2 NR3C1 ADRBK1 MAP1LC3A TARDBP GSK3B EP300 RAC1 SNCA CFTR PRKCZ APC ISG15 HDAC11 BDNF PARK2 ERG SP1 CD133 SQSTM1 DLG4 CSNK2A2 PXN HEL113 IKBKAP FAT10 OPTN NEDD9 HIF1A GSK3A KALRN ATXN3 CCDC141 HSPA4 MIIP ARID3A GRIA2 SNCAIP FUS GARS1 SGK1 CNOT6 MYD88 RHOT1 MAPK1 STUB1 PARKINSON 39 S DISEASE PATHWAY%WIKIPATHWAYS_20260710%WP2371%HOMO SAPIENS Parkinson 39 s disease pathway UBE2L6 ATXN2 UBE2G1 UBE2G2 SEPT5 CCNE2 SYT11 UBA7 DDC SLC6A3 PINK1 CASP9 LRRK2 CASP3 APAF1 CYCS GPR37 TH UBE2J1 SNCA HTRA2 UBE2J2 CASP2 CCNE1 PARK2 UBB UBE2L3 CASP6 MAPK14 MAPK12 MAPK13 MAPK11 EPRS1 HEL-117 SNCAIP HEL-S-67p ID SIGNALING%WIKIPATHWAYS_20260710%WP53%HOMO SAPIENS ID signaling PAX2 CDK2 ELK3 CCNE1 ID1 RBL1 MYOD1 ID3 PAX5 RBL2 GIG8 PAX8 RB1 ATOPIC DERMATITIS MECHANISM AND THERAPIES%WIKIPATHWAYS_20260710%WP5538%HOMO SAPIENS Atopic dermatitis mechanism and therapies TYK2 OSMR TSLP IL13 IL33 FCER1A MS4A2 IL13RA1 IL4 IL5 IL1RL1 IL2RG CRLF2 FCER1G IL25 JAK3 STAT3 LEPTIN AND ADIPONECTIN%WIKIPATHWAYS_20260710%WP3934%HOMO SAPIENS Leptin and adiponectin LEPR ADIPOR1 ADIPOR2 CPT1A PRKAA1 LEP PRKAG1 PRKAB1 ACACA P38 MAPK SIGNALING%WIKIPATHWAYS_20260710%WP400%HOMO SAPIENS p38 MAPK signaling MAX MEF2D TGFBR1 GRB2 HEL-S-102 TRADD STAT1 MAP3K1 RIPK1 RAC1 RASGRF1 RPS6KA5 HRAS DDIT3 ATF2 CREB1 SMIM40 MAPKAPK2 MAPKAPK5 MAP3K5 MAP2K6 MAP2K4 SHC1 TRAF2 MAPK14 MYC MAP3K7 HMGN1 CDC42 OVERVIEW OF NANOPARTICLE EFFECTS%WIKIPATHWAYS_20260710%WP3287%HOMO SAPIENS Overview of nanoparticle effects BCL2 HMOX1 BAX NFRKB PTGS2 TNF PTGS1 LAMA3 CRP AKT3 CCND3 PIK3CD CXCL8 IL6 COL4A1 AUTOPHAGY IN PANCREATIC DUCTAL ADENOCARCINOMA%WIKIPATHWAYS_20260710%WP5331%HOMO SAPIENS Autophagy in pancreatic ductal adenocarcinoma MDM2 AGER VMP1 PARK2 DKFZp762B153 IPO8 PINK1 SQSTM1 TFEB SHOC2 HMGB1 NFKB1 NFE2L2 STAT3 CHEMOKINE SIGNALING%WIKIPATHWAYS_20260710%WP3929%HOMO SAPIENS Chemokine signaling CCR10 NFKBIA XCR1 CXCL9 CXCL3 GRB2 NCF1 PPBP PREX1 PARD3 ELMO1 DOCK2 PRKX CCL4 CCL3 CCL1 c-fgr CX3CL1 CCR8 STAT3 CXCR5 CXCR6 CCL19 ADCY3 ADCY1 ADCY8 CCL25 PTK2B ADCY6 CCL24 ADCY5 VAV1 NFKBIB CXCL14 GNAI3 CXCR4 GNAI1 STAT1 GSK3B RAC1 PIK3CD PIK3R3 PIK3R1 NRAS CRKL XCL1 SHC2 RAF1 PIK3CA CX3CR1 TIAM1 GNG10 CCL7 SHC4 GNG12 GNG11 RELA GNG13 LYN PAK1 GNGT2 CCL5 MAPK1 MAPK3 DKFZp686L0365 PRKCB GRK5 GRK4 PLCB3 CXCL11 PLCB4 ADCY9 IL8RB PRKACG PLCB1 PLCB2 GNB2 GNB4 GNB3 GNB5 STAT2 GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 CCR6 FOXO3A JAK3 CCL17 STAT5B CCL11 SOS2 PIK3R5 CCL15 GRK1 CCL22 CCL21 CCR1 ADRBK1 CXCR3 CCL27 CCR7 PF4 CCL26 CCR4 AKT3 CCR3 CCR2 CXCL13 NFKB1 CXCL16 HRAS PRKCZ CXCL5 VAV3 MAP2K1 CCL20 CHUK GNGT1 IKBKB VAV2 CXCL12 GNB1 IKBKG SOS1 CRK CCL28 SHC3 SHC1 PXN PIK3R2 RAP1A ROCK1 ITK ROCK2 CSK WAS WASL CDC42 MOLECULAR PATHWAY FOR OXIDATIVE STRESS%WIKIPATHWAYS_20260710%WP5477%HOMO SAPIENS Molecular pathway for oxidative stress HMOX1 BCL2 BCL2L1 CDK2 FOXO1 KEAP1 PTGS2 TNF PINK1 CHEK1 GSX1 IPCEF1 MTOR PIP NRF1 NQO1 PTEN TSC1 NFKB1 CXCL8 RPS6KA5 NFE2L2 SIRT1 ATF2 CDKN1A MDM2 MAPK8 NOS2 CREB1 IKBKB IL1A CCNE1 ATR MAP3K5 IKBKG MAP2K3 PIK3CA MAP2K4 RHEB FOS MAPK14 IL6 CELL DIFFERENTIATION EXPANDED INDEX%WIKIPATHWAYS_20260710%WP2023%HOMO SAPIENS Cell differentiation expanded index TLX3 KLF4 MEF2D TLX2 MEF2C RUNX2 LEFTY2 MYOD1 GIG8 PAX7 HDAC5 SOX2 EZH2 TLX1 MEF2B LEFTY1 STAT3 SREBF AND MIR33 IN CHOLESTEROL AND LIPID HOMEOSTASIS%WIKIPATHWAYS_20260710%WP2011%HOMO SAPIENS SREBF and miR33 in cholesterol and lipid homeostasis HMGCS1 ABCA1 HMGCR NR1H3 LDLR SREBF2 PPARGC1A MTOR SCD SIRT6 MED15 PRKAA1 FASN NR1C1 SIRT1 FARNESOID X RECEPTOR PATHWAY%WIKIPATHWAYS_20260710%WP2879%HOMO SAPIENS Farnesoid X receptor pathway FGF19 ABCB4 SLC27A5 NR1H4 ABCB11 FKBP5 RXRA CYP3A4 CYP7A1 NR0B2 PPARGC1A BAAT SLCO2B1 SULT2A1 CYP8B1 UGT2B4 IP6K3 7Q11 23 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260710%WP4932%HOMO SAPIENS 7q11 23 copy number variation syndrome UBE2L6 SNAP25 MAPK3 GRB2 EIF2A ATP5G1 ATF4 HEL-S-271 ABHD11 BCL7B GTF2I HDAC2 BUD23 CLASP1 ATPAF2 UBIAD1 VPS9D1 UBE2E3 VPS37C HMGA1 VPS37D VPS37A MYBBP1A NRG1 VPS37B CLIP2 CLDN3 RB1 HEL-S-162eP METTL27 FKBP6 LAT2 VPS28 ATPAF1 TRIM50 FBLN2 FBLN5 MVB12A CLASP2 TSG101 ATP8 TMEM270 TBL2 OGDH GTF2IRD1 ATP6 ATP5MC2 PRKG1 DLD ATP5MC3 HEL-S-15 HEL-S-123m EIF4H USF1 RFC2 MYC PKLR ATP5PB ATP5F1D ATP5F1E ATP5PO CDKN1C DDX21 MYO1C CHTF18 VAMP2 ACACB FZD9 FBN1 BTK STX1A CLTC SMARCA5 DEK BRD4 NUP62 BAZ1B CLDN4 PCNA HDAC3 CLDN5 ULK1 MLXIPL SQSTM1 LIMK1 HOXC8 H2AX HSPA2 UBE2E1 GRIP1 ACACA CLDN1 ENDODERM DIFFERENTIATION%WIKIPATHWAYS_20260710%WP2853%HOMO SAPIENS Endoderm differentiation ZIC5 LHX1 FOXO1 GDF3 LRPPRC NODAL SOX7 CER1 TCF4 GATA4 ELAVL1 WWC1 SFMBT1 CDYL RFX7 RAB38 CTR9 PRDM14 RTF1 FOXN3 SP4 SFRP1 PAF1 TAF4B ONECUT1 HOXC11 CDC73 HHEX Pax9 BTAF1 TCEAL2 LEO1 KDM4A NOG TNRC6C FOXH1 OTX2 APP NR1B3 PTHLH TAF5 BMPR1A PABPC1 SMAD2 STAT1 BMP7 LAMC1 CEBPZ DUSP4 FOXA1 NKX2-1 CRTC1 SIAH2 TCF2 ACACA EZH2 DUSP2 DUSP5 SOX21 SOX2 SOX17 SESN1 CEP250 CTBP2 WDHD1 EMSY WDFY2 BCORL1 TOX GATA6 DKK1 MBTD1 EPB41L5 UBR5 ATP8B2 MAP2K3 NOTCH1 PBX3 CAND1 ZFHX4 PBX1 EXT1 NABP2 PLCH1 C1QBP TRIM71 BCAR2 PHF6 TBX21 ZIC3 TRIM5 JARID2 MAD2L2 SLC2A12 NLK LEF1 TET1 POU5F1 PARP8 TOX3 AEBP2 AHDC1 CUL4B WNT3 ZNF462 NR3C1 ELP4 TCF7L1 SMAD4 RGS10 MIXL1 FOXA2 APC VAV3 PIAS1 HOXA1 TGFB1 PAX3 BPTF WNT8A DNMT3B SARS COV 2 AND ACE2 RECEPTOR MOLECULAR MECHANISMS%WIKIPATHWAYS_20260710%WP4883%HOMO SAPIENS SARS CoV 2 and ACE2 receptor molecular mechanisms ACE2 TMPRSS2 AGTR1 MAS1 REN LNCRNA IN CANONICAL WNT SIGNALING AND COLORECTAL CANCER%WIKIPATHWAYS_20260710%WP4258%HOMO SAPIENS lncRNA in canonical Wnt signaling and colorectal cancer CHD8 CSNK2B LRP6 PORCN FZD1 CSNK1A1 FZD7 FZD8 CER1 CTNNBIP1 SFRP4 SOX17 KREMEN1 SENP2 SFRP5 CTBP2 CXXC4 NKD1 NKD2 NOTUM FZD2 TFAP2A SOST DKK1 FZD5 WNT2B JUN LRP5 SFRP1 FRAT1 CCND3 CCND2 MYC MAP3K7 WIF1 WNT5B AXIN1 WNT16 DKK2 LEF1 NLK DVL1 DVL2 DVL3 FRAT2 WNT1 WNT3 WNT4 APC2 WNT10B TCF7L2 CSNK1A1L RUVBL1 WNT10A TCF7L1 CCND1 GSK3B FZD9 WNT3A WNT7B DKK4 FZD10 WNT7A FOSL1 APC MACROH2A2 CDK6 CDK8 CTBP1 hCG_2014051 CSNK2A1 RYK CSNK2A3 CSNK2A2 ROR1 ROR2 AXIN2 TCF3 EZH2 ATF3 FZD3 BARDET BIEDL SYNDROME%WIKIPATHWAYS_20260710%WP5234%HOMO SAPIENS Bardet Biedl syndrome IFT74 DYNC2I2 TRAF3IP1 IFT172 CRX TTC8 IFT80 LZTFL1 IFT81 CEP164 CLUAP1 NEK1 CFAP418 RP2 CFAP410 TMEM216 CEP104 WDPCP ARL3 BBS2 ARL13B NEK8 ARL6 TMEM67 INPP5E BBS1 PKHD1 DCDC2 FUZ BBIP1 PTCH1 CEP41 FLCN TMEM107 CNGA1 GLI3 ZIC2 MKS1 BBS10 BBS12 IFT27 SCAPER EFHC1 CNGB1 SDCCAG8 SMO PKD1L1 IFT52 RAB23 BBS9 SUFU NPHP3 OCRL BBS7 EVC2 IFT57 USP9X PCARE CEP290 SCLT1 BBS5 KIF7 EVC IQCB1 TRIM32 PKD1 WDR35 IFT140 BBS4 IFT43 EFHC2 INVS GPR161 DYNC2H1 PDE6D DYNLT2B DYNC2LI1 OSTEOPONTIN SIGNALING%WIKIPATHWAYS_20260710%WP1434%HOMO SAPIENS Osteopontin signaling opn CHUK IKBKB MAP3K14 MAPK3 RELA ITGB3 ITGAV NFKB1 MAP2K1 MAPK1 MMP9 7Q11 23 DISTAL COPY NUMBER VARIATION%WIKIPATHWAYS_20260710%WP5401%HOMO SAPIENS 7q11 23 distal copy number variation TMEM120B SFN TMEM120A SSC4D POR STYXL1 SRRM3 HEL163 HEL-S-102 LMNA KIF1C RAF1 YWHAG RHBDD2 PTPMT1 ZP3 ZP2 DAPK2 MDH2 MITOCHONDRIAL FISSION AND FUSION%WIKIPATHWAYS_20260710%WP4318%HOMO SAPIENS Mitochondrial fission and fusion MFN1 BAX MFN2 BCL2L1 SH3GL2 FIS1 OPA1 MTFP1 BNIP3 MIB1 STEROID HORMONE PRECURSOR BIOSYNTHESIS%WIKIPATHWAYS_20260710%WP5277%HOMO SAPIENS Steroid hormone precursor biosynthesis CYP11A1 AKR1C1 HSD3B1 AKR1D1 HSD3B2 SRD5A2 CYP17A1 CYP21A2 CHOLESTEROL SYNTHESIS DISORDERS%WIKIPATHWAYS_20260710%WP5193%HOMO SAPIENS Cholesterol synthesis disorders LBR FDFT1 FDPS HMGCS1 HMGCR HSD3B2 DHCR24 SQLE MVD DHCR7 CYP51A1 MVK MSMO1 EBP PMVK SC5D MBDNF AND PROBDNF REGULATION OF GABA NEUROTRANSMISSION%WIKIPATHWAYS_20260710%WP4829%HOMO SAPIENS mBDNF and proBDNF regulation of GABA neurotransmission NGFR GABRB3 GABRB2 GABRB1 AP2A1 GABRA3 AP2A2 PLCG1 PTEN ARHA PIK3R3 PIK3R1 STAT3 NTRK2 CREB1 GABRE BDNF GABRQ GABRA2 CREM GABRP SLC12A5 GABRA6 PIK3CA GABRA5 GABRA4 SHC1 PIK3R2 ROCK1 GABRG3 GABRG1 PI3K AKT MTOR VITAMIN D3 SIGNALING%WIKIPATHWAYS_20260710%WP4141%HOMO SAPIENS PI3K AKT mTOR vitamin D3 signaling NR1i1 HEL-S-133P CYP24A1 RXRA IL10 PIK3CA CD80 TSC2 MTOR IL12A GSK3B SLC2A3 PRKAA2 RELA HK3 MYC TSC1 PFKFB4 PDHA1 HEROIN METABOLISM%WIKIPATHWAYS_20260710%WP2645%HOMO SAPIENS Heroin metabolism CES2 CES1 BCHE MECHANOREGULATION AND PATHOLOGY OF YAP TAZ VIA HIPPO AND NON HIPPO MECHANISMS%WIKIPATHWAYS_20260710%WP4534%HOMO SAPIENS Mechanoregulation and pathology of YAP TAZ via Hippo and non Hippo mechanisms MAPK10 NF2 MAPK9 YWHAQ PS1TP5BP1 ITGB3 CTNNA1 LIMD1 ITGB4 ITGB8 ITGB7 ITGB6 MAPK8 SGMS1 ACTG2 TEAD2 TEAD3 TEAD4 LATS1 SRC HEL-S-31 ITGB1 ACTA2 MAP4K1 MAP4K2 ACTA1 PAK6 PAK1 MAP4K3 PAK4 YAP1 ACTG1 WWTR1 ANGIOTENSIN II RECEPTOR TYPE 1 PATHWAY%WIKIPATHWAYS_20260710%WP5036%HOMO SAPIENS Angiotensin II receptor type 1 pathway COL1A1 ACE2 COL1A2 TGFBR1 TGFBR2 JUND SP1 IL6ST AGTR1 IL11RA RAF1 MAP2K6 TGFB1 SMAD4 PDGFD NOX4 ACTA2 HIF1A RRAS MAS1 CTGF IL11 PTPN11 MAPK1 DICLOFENAC METABOLIC PATHWAY%WIKIPATHWAYS_20260710%WP2491%HOMO SAPIENS Diclofenac metabolic pathway CYP2B6 CYP2C9 CYP2C19 CYP2C18 CODEINE AND MORPHINE METABOLISM%WIKIPATHWAYS_20260710%WP1604%HOMO SAPIENS Codeine and morphine metabolism UGT1A3 UGT1A9 UGT2B7 ABCB1 SLCO1B1 CYP3A4 UGT1A8 ABCC3 UGT2B4 UGT1A10 ABCC2 UGT1A1 ESTROGEN RECEPTOR PATHWAY%WIKIPATHWAYS_20260710%WP2881%HOMO SAPIENS Estrogen receptor pathway CYP1A2 CYP1A1 GPAM ACOX1 SP1 PDK4 CYP1B1 NR0B2 NR1C1 PCK1 JUN STAT3 ENTEROHEPATIC CIRCULATION OF BILE ACIDS%WIKIPATHWAYS_20260710%WP5396%HOMO SAPIENS Enterohepatic circulation of bile acids FABP6 SLC51A SLC51B ABCB1 SLC10A2 ABCB11 SLCO1B1 ABCC3 ABCC2 MITOCHONDRIAL COMPLEX IV ASSEMBLY%WIKIPATHWAYS_20260710%WP4922%HOMO SAPIENS Mitochondrial complex IV assembly COX19 COX16 COX18 COX5A TACO1 HIGD1A PET117 COX14 COA6 COX3 COX10 COX2 PET100 COX1 FAM36A COXFA4 CMC1 TMEM177 PNKD SMIM20 COX7B COX6A1 COX7C COA3 COX17 COX8A COX11 COX7A2 COX6B1 SURF1 PARTHANATOS CELL DEATH SIGNALING PATHWAY%WIKIPATHWAYS_20260710%WP5585%HOMO SAPIENS Parthanatos cell death signaling pathway AIFM1 EFFECTS OF MFN2 MUTATION%WIKIPATHWAYS_20260710%WP5443%HOMO SAPIENS Effects of MFN2 mutation BAX DYNC2I2 MFN2 RAB3B DYNC1H1 DYNC1I1 DYNC1LI2 DCTN1 SYPL1 CASP8 CASP3 KIF1B DYNC2H1 RABAC1 RAB7A TRAK1 ATAT1 SNCA RHOT1 MAP2 PRIMARY OVARIAN INSUFFICIENCY%WIKIPATHWAYS_20260710%WP5461%HOMO SAPIENS Primary ovarian insufficiency ALOX12 CLPP WT1 KHDRBS1 STAG3 EIF2B5 NR5A1 STAR EIF2B1 POLR2C AMHR2 DCAF17 TGFBR3 POLR3H EIF2B2 BMPR1A PCCA RAD51 PCCB SALL4 COX10 NBN BRCA2 LAMC1 PRORP ANTXR1 MEIOSIN POF1B BMP15 MEIOB SIL1 AMH PPM1B NANOS3 LARS2 PREPL MSH4 NOBOX AARS2 AIRE MST1R BLM HMMR WDR62 STRA8 SYCE1 SOHLH1 KASH5 SOHLH2 SWI5 HELQ ERAL1 DIAPH2 H1-8 HSD17B4 HROB HSD17B1 LHX8 PGRMC1 MCMDC2 ELAVL2 FIGLA DAZL C1orf146 MSH5 MRPS22 FOXL2 DMC1 SPIDR ZP3 ZAR1 SIX6OS1 HAX1 PSMC3IP RECQL4 SLX4 CCDC185 MGME1 C10orf2 MND1 LMNA CENPE NLRP11 XPNPEP2 SPATA33 RFWD3 BMPR2 FSHR CYP17A1 TP63 WRN BMP6 NUP107 MCM9 NR3A2 SOX8 EIF4ENIF1 POLG FMR1 BNC1 FANCM ATM FANCL FANCA GNAS ATG9A NOTCH2 GANGLIO SERIES SPHINGOLIPID METABOLISM%WIKIPATHWAYS_20260710%WP5299%HOMO SAPIENS Ganglio series sphingolipid metabolism B3GALT4 ST8SIA5 ST3GAL5 B4GALNT1 HEL-S-111 HEXA SIAT4C ST3GAL1 NEU3 NEU4 ST8SIA6 ST8SIA1 ULCERATIVE COLITIS SIGNALING%WIKIPATHWAYS_20260710%WP5174%HOMO SAPIENS Ulcerative colitis signaling MAF IL13 FOXP3 GATA3 IL10 TNF IL4 IL5 TGFB1 HLA-DMA IL2RG NFKB1 NFATC1 IFNG NOD2 DENGUE 2 INTERACTIONS WITH COMPLEMENT AND COAGULATION CASCADES%WIKIPATHWAYS_20260710%WP3896%HOMO SAPIENS Dengue 2 interactions with complement and coagulation cascades THBD CFB CFH CFI HEL-S-78p KNG1 PLAT VWF BDKRB1 F2 SERPING1 KLKB1 F3 C1QB C1QA C1S C5AR1 C4B_2 C3AR1 CR2 SERPINA1 PROS1 CLTC C1QC CLU C8G SERPINF2 F5 F7 F8 F9 MASP2 MASP1 CD46 CFD CPB2 SERPINC1 PLG TFPI LMAN1 C6 F13B C7 C9 CD55 F10 SERPIND1 HEL-S-62p PROC APOA2 CR1 PLAUR F2R OMEGA 3 OMEGA 6 FATTY ACID SYNTHESIS%WIKIPATHWAYS_20260710%WP4723%HOMO SAPIENS Omega 3 omega 6 fatty acid synthesis ELOVL5 ELOVL2 ACOX1 PLA2G5 ACSL1 PLA2G4B FACL4 ACSL3 PLA2G6 FADS2 ACOX3 FADS1 VITAMIN D SENSITIVE CALCIUM SIGNALING IN DEPRESSION%WIKIPATHWAYS_20260710%WP4698%HOMO SAPIENS Vitamin D sensitive calcium signaling in depression BCL2 CYP27A1 TPH2 CHRM1 KDM3A KCNQ2 TPH1 KDM1B ITPR2 CALB1 CYP27B1 ATP2B4 KCNQ3 PVALB HEL-75 CACNA1C GCLC NFE2L2 NR1i1 ATP2B3 GRIN2B ATP2B2 RXRA ATP2B1 GRIN1 KDM1A KDM6B SLC8A1 INTEGRATED BREAST CANCER PATHWAY%WIKIPATHWAYS_20260710%WP1984%HOMO SAPIENS Integrated breast cancer pathway NUP85 TPR FOXO1 FOSL2 DHTKD1 HIPK2 BRCA1 STK11 XRCC3 JAK1 MAX TGFBR1 RALA TGFBR2 BMPR1A EDAR SMAD2 RAD50 SMARCA4 RAD51 STAT1 MRE11A CCND1 SMAD6 BRCA2 EP300 RAC1 PTEN FAU TSC1 BARD1 BACH1 SIRT1 ATF1 CREB1 MAP3K7IP1 BLM NOXA1 RHEB MAP3K13 NF1 ERAL1 GSK3A RASGRP3 ANXA1 PAK1 MAPK1 VEGFA CDK2 CHEK2 CHEK1 TRADD MTOR ZMYND8 CASP9 NAB1 CDC25B MSH2 CASP8 MAP3K7CL CASP3 ZMIZ1 ALKBH1 RALGAPA1 FADD PKIA HDAC1 CCNB1IP1 LGALS13 RRAS BMPR2 UBE2F PML PLK3 FER ZNF655 PIGR RB1 RASGEF1A DCAKD ITPKC GRN EGFR USP16 PLK1 USP21 FILIP1 BAK1 ATR JUN IRS1 MYC SMAD1 BCL2 WEE1 BAX CDK7 GDI1 SMEK1 AURKA ARAF APOBEC3G TSC2 SMAD4 RPP38 GADD45A BAD AHR NFKB1 PPP4R3B MSH6 FOSL1 SELENOK MDM2 ATM MYT1 CDK4 CHUK PIAS1 SP1 HMGCR CERK TFPI CSNK1D PIK3R2 RAP1A DAG1 RHO USP15 MYCBP2 CDC42 GASTRIN SIGNALING%WIKIPATHWAYS_20260710%WP4659%HOMO SAPIENS Gastrin signaling NFKBIA MEF2D GRB2 FOXO1 PTGS2 FYN PRKCA BIRC5 SERPINB2 KAT5 ARHA TCF4 PRKD2 PRKD1 HDAC7 ELAVL1 STAT3 PRKCE PRKCQ KIT MEF2C CCND1 GSK3B PLCG1 RAC1 RPS6 PIK3R3 PIK3R1 SLC9A3 EIF4EBP1 CREB1 KLF4 RAF1 PIK3CA MAP3K11 RELA PAK1 ANXA2 MAPK1 VEGFA LAMTOR3 MAPK3 DKFZp686L0365 RHOD MTOR YES1 CASP3 MMP7 RPS6KB1 BIRC3 EGR1 CCKBR ATF2 CDKN1A EGFR MAPK8 ARHGEF28 TFF2 HDC JUN CDKN1B TJP1 IRS1 GAST CDKN2A FOS MAPK14 IL2 MYC FOXO3A PTPN11 BCL2L1 MAPK9 BMP2 BIRC2 BAD MEF2B PRKCH NFKB1 CXCL8 HRAS MAP2K1 PPARG CHUK IKBKB SP1 SOS1 CRK SHC1 SRC PXN PIK3R2 ITGB1 RHOB ROCK1 CD44 CLDN1 CDC42 COMPLEMENT SYSTEM IN NEURONAL DEVELOPMENT AND PLASTICITY%WIKIPATHWAYS_20260710%WP5090%HOMO SAPIENS Complement system in neuronal development and plasticity C4A PARD3 VTN CFB CASP9 CFH CASP8 CFI CASP3 CFP CYCS CX3CL1 HTRA2 TYRO3 BAK1 FCN2 PATJ SERPING1 FCN3 C4BPA ATP8B2 C4BPB CASP10 DLGAP5 PARD6A ATP11C SCRIB MARK1 PLSCR3 C8A PLSCR4 MFGE8 LLGL2 DIABLO CRB2 COLEC12 CRB1 COLEC10 PARD6G CD59 DEDD MERTK ATP8B3 AXL TNFSF6 IFNG BAX PLSCR1 CAP1 ITGB3 ITGAM C1QB C1QA ATP11A C1S C5AR2 C5AR1 C4B_2 C3AR1 CR2 APAF1 ITGAX PROS1 ITGAV PRKCI C1QC CLU C8G PRKCZ ATP8B1 MBL2 MASP2 MASP1 FCN1 CD46 CFD COLEC11 C6 CX3CR1 C7 C9 PALS1 CD55 TGFB1 HEL-S-62p PARD6B CR1 ATP10A MBP TCA CYCLE AND DEFICIENCY OF PYRUVATE DEHYDROGENASE COMPLEX PDHC %WIKIPATHWAYS_20260710%WP2453%HOMO SAPIENS TCA cycle and deficiency of pyruvate dehydrogenase complex PDHc FH OGDH PC SUCLG2 DLD HEL-S-32 SDHA HEL60 CS ACLY HEL-S-26 PCK1 PDHA1 DLAT GDNF RET SIGNALING AXIS%WIKIPATHWAYS_20260710%WP4830%HOMO SAPIENS GDNF RET signaling axis PAX2 EYA1 BMP4 IFT25 LHX1 GDNF FOXC2 FOXC1 ROBO2 ALDH1A2 WT1 SOX11 SOX17 GREM1 GATA3 ROBO1 AGTR2 SLIT2 TCF2 RET HOXC11 SPRY1 HOXD11 FAT4 GLI3 HOXA11 SALL1 IFT27 SIX2 PRE IMPLANTATION EMBRYO%WIKIPATHWAYS_20260710%WP3527%HOMO SAPIENS Pre implantation embryo FOSB SOX11 SOX2 HMGA1 EGR1 ELAVL1 GATA3 TFAP2B HNRNPAB BATF3 TEAD4 ATP1A1 PBX1 FOXD1 MTA3 GATA2 NANOGNB NR3C2 FOXQ1 E2F5 KHSRP ARGFX DPPA3 ZFP42 DLX2 POU5F1 PADI6 BARX2 IRF4 LEUTX AQP3 CDX2 TPRX1 MOS DPRX ZSCAN4 MXD1 MYBL1 SMARCA4 TBX3 TCF7L1 SOX8 ESRRA IRX5 DDIT3 MACROH2A2 KLF4 NKX2-1 AQP9 ZFP36 ZFP36L2 DNMT3L ZAR1 SIX3 CELL INTERACTIONS IN PANCREATIC CANCER MICROENVIRONMENT%WIKIPATHWAYS_20260710%WP5284%HOMO SAPIENS Cell interactions in pancreatic cancer microenvironment VEGFA NRP1 CXCR4 CXCL12 HLA-DRB1 IFITM2 CSF1R CSF2 TGFB1 CD80 CSF2RA BAG3 CXCR3 CTLA4 KDR CCR2 CCR5 CSF1 ITGB6 TNFSF6 CCL5 CCL2 22Q11 2 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260710%WP4657%HOMO SAPIENS 22q11 2 copy number variation syndrome SEPT5 SLC25A1 EMC10 GP9 CLDN3 CLTCL1 GLUD1 HEL25 FGFR1 CDH15 POLR2A FGF8 SLC2A4 NCOR1 MED15 HEL-S-80p DRD2 CRKL CYP26A1 RAF1 SREBF2 ACTA2 CYP26B1 RELN ALDH1A2 ASF1A SHOC2 PITX2 CYP26C1 EGFR H4C9 PLK1 VWF CDC45 GP1BA RBX1 BCL2 SHH RORC FGF10 DGCR8 DROSHA RAN FOXC2 FOXC1 TSKS ZDHHC8 RCC1 GSC2 PRODH C22orf39 HAND2 THAP7 RTL10 NPRL2 TRMT2A FOXA2 ESS2 KLHL22 SNAP29 TXNRD2 GP5 TBX1 UFD1L LRRC74B SEPT8 MRPL40 DGCR6L TNPO1 SCARF2 DGCR2 GP1BB NKX2-5 C16orf35 SLC7A4 GNB1L DEPDC5 HDAC3 RTN4R FGFR2 CCDC188 PARK2 hCG_1641087 ARVCF CLDN5 RANBP1 RTN4 P2RX6 HIRA ZNF74 HIRIP3 PAX3 SERPIND1 GBX2 CLDN1 HES1 PAK4 CDC42 OREXIN RECEPTOR PATHWAY%WIKIPATHWAYS_20260710%WP5094%HOMO SAPIENS Orexin receptor pathway CXCL2 BGLAP MAPK3 CGA FOXO1 DKFZp686L0365 PRKCB PRKCA OPRK1 POMC HCRTR2 MTOR HCRTR1 CASP9 GHRL CASP3 RPS6KB1 PRKD1 NFE2L2 STAT3 DKFZp781O1323 MAPK8 GNA11 NPY STAR RUNX2 GCG PRKCE VHL CCK NOX4 MAPK14 LHB SMAD1 IL6 PTPN11 GNRH1 MAPK9 LEP BMPR1A DAGLA SLC2A4 TNF RPS6KA1 GNAI1 PRKAA1 TH IL1B BMP7 RPS6 GH1 CXCL8 PIK3R1 PRKCZ DYNLT1 MAP2K1 MAP2K2 DYNLT3 EIF4EBP1 PDPK1 CREB1 NPFFR1 FSHB GNAS IL10 NPVF HCRT IL4 PIK3R2 HIF1A MAPK7 CAMKK2 IL9 SGK1 SLC1A2 MAPK1 EIF4B SMALL CELL LUNG CANCER%WIKIPATHWAYS_20260710%WP4658%HOMO SAPIENS Small cell lung cancer NFKBIA CCNE2 COL4A4 COL4A3 CDK2 COL4A5 LAMA5 PTGS2 BIRC7 FHIT LAMB2 COL4A6 SKP1 CASP9 CASP8 CASP3 CYCS BIRC3 RB1 CDKN1A GADD45B LAMC2 GADD45G BAK1 RXRB LAMA1 LAMA3 CDKN1B RXRG TRAF2 NFKBIB LAMB3 MYC LAMB4 E2F2 E2F3 LAMB1 DDB2 TRAF6 TRAF5 BCL2 POLK MAX BAX BCL2L1 CDKN1C ITGA2B RARB BIRC2 CCND1 AKT3 APAF1 LAMA4 GADD45A PTEN TRAF1 LAMC1 PIK3CD TRAF3 ITGAV PIK3R3 COL4A2 NFKB1 COL4A1 PIK3R1 CDKN2B TRAF4 NOS2 CDK6 CKS1B CHUK ITGA2 CDK4 IKBKB CCNE1 RXRA IKBKG ITGA6 PIK3CA CKS2 ITGB1 PIK3R2 RELA SUDDEN INFANT DEATH SYNDROME SIDS SUSCEPTIBILITY PATHWAYS%WIKIPATHWAYS_20260710%WP706%HOMO SAPIENS Sudden infant death syndrome SIDS susceptibility pathways PHOX2B PAH SNAP25 YWHAQ LMX1B HSPD1 SCN5A TPH1 CTCF HTR2A HEL-S-162eP ECE1 MAP2 HTR1A TLX3 SNTA1 MAOA FREP1 PRKAR1B HEL-S-87p PRKAR1A RET ASCL1 POU2F2 SST RUNX3 G6PC1 MEF2C DDC TNF SLC25A4 VAMP2 RORA EP300 MYB CHRNB2 SSTR2 CHRNA7 PPARGC1B NKX3-1 SLC9A3 CREB1 NTRK2 NGF NFYA BDNF RYR2 GRIN1 CREM SCN3B AQP4 GJA1 HIF1A NR1A2 TACR1 SLC1A3 VEGFA CPT1A HEL2 CHRM2 C4A HADHB AVP NEUROD1 ACADM GCK REST CASP3 HDAC1 SOX2 POU3F2 EGR1 CEBPB GNB3 CREBBP YBX1 TF IL1A GATA3 HEL-S-1 YWHAG JUN PBX1 BHLHB2 GATA2 IL6 DLX2 IL6R SP3 POU5F1 TPH2 NR3A2 PPARGC1A NR3C1 C4B_2 NKX2-2 ChAT TH IL1B SCN4B CHRNB4 NFKB1 NFKB2 CXCL8 TP73 IL13 SP1 IL10 FOXM1 VIPR2 PKNOX1 TSPYL1 ADCYAP1R1 TCF3 DEAF1 SPTBN1 HEL-S-125m HEL-S-93 PHOX2A FEV IL1RN CC2D1A NOS1AP KCNJ8 GPD1L HES1 HES5 CAV3 EN1 FLUOROACETIC ACID TOXICITY%WIKIPATHWAYS_20260710%WP4966%HOMO SAPIENS Fluoroacetic acid toxicity ALDH9A1 ALDH3A2 CS ACSS2 ALDH2 ACO2 17Q12 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260710%WP5287%HOMO SAPIENS 17q12 copy number variation syndrome PNMT AATF STARD3 IKZF3 CISD3 DUSP14 TBC1D3H RDM1 LHX1 ARL5C PEX12 C17orf50 GPR179 UNC45B SLC35G3 SRCIN1 SLFN12 SLFN13 RAD51D TCAP TBC1D3 SLFN11 SLFN14 ZNF830 SLFN5 GGNBP2 SOCS7 FBXO47 CCL8 MRM1 CCL4 MLLT6 CCL3 CCL3L3 FBXL20 CCL1 NEUROD2 CCL16 MIEN1 ZNHIT3 C17orf78 ASIC2 GAS2L2 HEATR9 PPP1R1B TAF15 TMEM132E RASL10B PCGF2 CCL14 SYNRG TEC CCL13 EPOP PLXDC1 NLE1 ARHGAP23 HEL-S-6a CCL18 TBC1D3K GRB7 STAC2 CDK12 SPMAP1 RPL23 CCL4L2 CCL11 PIP4K2B CCL15 ERBB2 CCT6B MMP28 MED1 RFFL CCL2 CCL7 TCF2 FNDC8 ACACA DHRS11 PGAP3 TBC1D3B TBC1D3E CACNB1 TBC1D3C PIGW CWC25 CCL5 TBC1D3I AGE RAGE PATHWAY%WIKIPATHWAYS_20260710%WP2324%HOMO SAPIENS AGE RAGE pathway NFKBIA HEL-S-44 AGER MAPK3 FOXO1 NCF1 PRKCB PRKCA CASP9 CASP8 CASP3 MMP7 CYCS ARHA ALPL EZR ATF2 STAT3 EGFR MAPK8 DDOST MMP14 MSR1 JUN IRS1 MMP2 MAPK14 STAT5B MAPK9 SMAD2 STAT1 RAC1 INHBB HEL70 INSR NFKB1 INS FOXO4 PRKCZ MAP2K1 NOS2 CHUK IRAK4 IKBKB TIRAP SP1 RAF1 SHC1 SRC ROCK1 HIF1A RELA MYD88 MMP9 CDC42 MAPK1 VISUAL CYCLE%WIKIPATHWAYS_20260710%WP5534%HOMO SAPIENS Visual cycle RDH8 RLBP1 RDH12 RDH10 LRAT ABCA4 RBP3 OPN1SW RDH11 RPE65 OPN1LW RBP1 RHO RDH5 OPN1MW MAMMALIAN DISORDER OF SEXUAL DEVELOPMENT%WIKIPATHWAYS_20260710%WP4842%HOMO SAPIENS Mammalian disorder of sexual development NR5A1 FGFR2 SOX9 DHH FGF9 WNT4 RSPO1 EMX2 PBX1 SOX8 RBFOX2 WT1 DMRT1 CBX2 INSL3 SRY FOXL2 MAPK11 AMHR2 GATA4 FST AMH MAP3K1 ROLE IN PROMOTING AND BLOCKING GONADAL DETERMINATION%WIKIPATHWAYS_20260710%WP4872%HOMO SAPIENS MAP3K1 role in promoting and blocking gonadal determination GADD45G FGFR2 SOX9 FGF9 WNT4 MAP3K1 GSK3B ROCK1 FRAT1 SRY ARHA FOXL2 MAPK11 AXIN1 MAPK1 BDNF TRKB SIGNALING%WIKIPATHWAYS_20260710%WP3676%HOMO SAPIENS BDNF TrkB signaling GAB2 GRB2 RPS6KA1 TSC2 MTOR RPS6KB1 PLCG1 TSC1 HRAS NRAS MAP2K1 EIF4EBP1 NTRK2 CREB1 HOMER1 BDNF GRIN1 ARC ADCY1 SOS1 RHEB DLG4 SHC1 EEF2K TRPC6 MAPK1 TRPC3 MITOCHONDRIAL COMPLEX I ASSEMBLY MODEL OXPHOS SYSTEM%WIKIPATHWAYS_20260710%WP4324%HOMO SAPIENS Mitochondrial complex I assembly model OXPHOS system NDUFA5 NDUFA13 NDUFA12 NDUFA10 NDUFC2 NDUFC1 NDUFS6 NDUFS5 NDUFS4 NDUFS1 ND2 ND5 ND4 NDUFB9 ND6 NDUFB8 NDUFB7 NDUFB6 NDUFB5 NDUFB4 NDUFB3 ND1 NDUFB2 NDUFB1 NDUFV3 TMEM186 NDUFV2 C3orf60 ACAD9 TMEM126B DMAC1 NDUFB11 DMAC2 NDUFA7 TMEM70 NDUFA6 TIMMDC1 ZNF183 COA1 NUBPL NDUFA3 NDUFA2 NDUFAF6 ND4L NDUFAF4 NDUFAF2 NDUFAF1 NDUFAB1 NDUFS3 ECSIT NDUFB10 TGFB SMAD SIGNALING%WIKIPATHWAYS_20260710%WP5382%HOMO SAPIENS TGFB Smad signaling SMAD4 TGFBR1 TGFBR2 TGFBR3 POSTN SPARC CTGF YWHAG SMAD2 WWTR1 FATTY ACID BIOSYNTHESIS%WIKIPATHWAYS_20260710%WP357%HOMO SAPIENS Fatty acid biosynthesis PECR MECR ACSL1 ECHDC1 FACL4 ECHDC2 ACSL3 PC ACSL6 ACSL5 SCD ACACB ECHS1 ACSS2 ACLY ACACA FASN DECR1 GPR40 ROLE IN INSULIN SECRETION%WIKIPATHWAYS_20260710%WP3958%HOMO SAPIENS GPR40 role in insulin secretion PLCB3 GNA11 PLCH1 PLCG1 PLCE1 PLCB1 PLCL1 FFAR1 PLCD3 PLCB2 PKD1 PLCG2 SOMATROPH AXIS GH AND ITS RELATIONSHIP TO DIETARY RESTRICTION AND AGING%WIKIPATHWAYS_20260710%WP4186%HOMO SAPIENS Somatroph axis GH and its relationship to dietary restriction and aging MTOR IGF1R PTEN FOXO1 SIRT1 ALPHA 6 BETA 4 SIGNALING%WIKIPATHWAYS_20260710%WP244%HOMO SAPIENS Alpha 6 beta 4 signaling MAPK3 GRB2 LAMA5 ITGB4 LAMB2 PRKCA MTOR RAC1 ARHA LAMC1 HRAS PIK3R1 EIF4EBP1 LAMC2 ITGA6 LAMA1 SOS1 LAMA3 SHC1 IRS1 SRC PIK3R2 MAPK14 LAMB3 LAMB1 MAPK1 PTPN11 MRNA VACCINE ACTIVATION OF DENDRITIC CELL AND INDUCTION OF IFN 1%WIKIPATHWAYS_20260710%WP5187%HOMO SAPIENS mRNA vaccine activation of dendritic cell and induction of IFN 1 IFIH1 TNFRSF11A IRF7 TLR7 MAVS TLR8 MR1 IRF3 TLR3 RIGI INTERLEUKIN 1 IL 1 STRUCTURAL PATHWAY%WIKIPATHWAYS_20260710%WP2637%HOMO SAPIENS Interleukin 1 IL 1 structural pathway NFKBIA MAPK10 MAPK9 MAPK3 SAFB IL1R1 MAP3K1 EIF4E IRAK2 NFKB1 RPS6KA5 TAB3 ATF2 MAP2K1 MAP2K2 MAPK8 CHUK IRAK4 MAP3K7IP1 IKBKB IL1A MAPKAPK2 MAP3K14 IRF7 TANK MAP3K8 MAP2K6 MAP2K3 MAP2K4 IRAK1 FOS MAPK14 NFKBIB RELA MYC MAPK11 MAP3K7 MBP TRAF6 MYD88 MAPK1 MALE INFERTILITY%WIKIPATHWAYS_20260710%WP4673%HOMO SAPIENS Male infertility PEX10 AGO2 MAS1L REC8 HEL110 XRCC5 TMEM132E CDK9 GNAO1 XRCC3 SHMT1 PON2 PON1 SRD5A2 ETV5 THBS1 CCNK TNF PSAT1 SLC46A1 PRDM9 SIRPG EPSTI1 RAG1 NANOS1 PRM2 PRM3 BRCA2 EP300 SPATA17 TSSK4 DDX4 DAZ4 DAZ3 VCX DAZ2 DND1 MOV10L1 H2BW1 TAS2R38 PUM2 PIWIL2 PIWIL1 PIWIL4 NOS2 MSH4 SPO11 HORMAD2 MSMB PRMT6 PACRG TEX15 CXXC1 STRA8 OR2W3 P1 USP26 CDC42BPA MLH3 CTCFL H3-4 SEMG1 TRIP13 CYP1A1 BRDT DAZL CHD2 MSH5 CYP26B1 MMP9 APOB UBE2B SLC16A7 HMGA1 GPX1 SIRPA NFE2L2 CREBBP H4C9 CYP17A1 XPC MMP2 PEMT RFC1 TNFSF6 BCL2 ERCC1 ABCB1 ERCC2 KDM3A NR3A2 POLG NQO1 AHR INSR CLU PMS2 MDM2 ATM SOX5 MTRR HEL-S-61p MTR AHRR FAT10 FOLH1 MTHFD1 TCN2 CHRONIC HYPERGLYCEMIA IMPAIRMENT OF NEURON FUNCTION%WIKIPATHWAYS_20260710%WP5283%HOMO SAPIENS Chronic hyperglycemia impairment of neuron function AGER SORD SNAP25 PRKCB MMP3 PRKCA TRPA1 MMP10 TRPV1 SLC2A3 MMP7 SCN8A MMP28 PRKCI PRKCH PRKCZ NOS2 BDNF SCN9A MMP14 PRKCE MMP2 HEL-S-62p MMP23B PRKD3 MMP25 MMP21 PRKCQ MMP20 MMP24 MMP27 MMP11 MMP16 MMP15 MMP17 MMP19 SCN10A MMP12 MMP9 CANNABINOID RECEPTOR SIGNALING%WIKIPATHWAYS_20260710%WP3869%HOMO SAPIENS Cannabinoid receptor signaling CNR2 MAPK10 CNR1 MAPK9 MAPK3 DAGLA CYP2C19 FAAH ADORA2A PRKACG AHR MAPK8 CYP3A4 ADCY1 CYP2C9 PRKAR1B PRKAR1A CYP1A1 MAPK14 MAPK12 MAPK13 MAPK11 NAPEPLD DAGLB MAPK1 SNARE COMPLEX MACHINERY IN EXOCYTOSIS%WIKIPATHWAYS_20260710%WP5621%HOMO SAPIENS SNARE complex machinery in exocytosis STXBP6 SNAP25 GDI1 RPH3A SYT1 CACNA1B SYP CACNA1A STX1B VAMP2 UNC13A NAPA STXBP1 CPLX1 RIMS1 STXBP5 METHIONINE DE NOVO AND SALVAGE PATHWAY%WIKIPATHWAYS_20260710%WP3580%HOMO SAPIENS Methionine de novo and salvage pathway AMD1 APIP MRI1 MTAP ADI1 SMS ENOPH1 MSRA MSRB2 MSRB3 IL4I1 HEL-S-61p MTR SRM MAT1A CHDH TXN UDP DERIVED SUGARS SYNTHESIS IN FIBROBLASTS%WIKIPATHWAYS_20260710%WP5394%HOMO SAPIENS UDP derived sugars synthesis in fibroblasts GFPT1 UGDH UXS1 HK3 PGM3 HK2 GCK CELL LINEAGE MAP FOR NEURONAL DIFFERENTIATION%WIKIPATHWAYS_20260710%WP5417%HOMO SAPIENS Cell lineage map for neuronal differentiation NGFR GFAP SNAP25 LHX1 MSX1 LMX1B TPH1 HTR5A NODAL GPHN GABBR1 GATA4 MAP2 TWIST1 ESRRB HTR1A DLG2 ROBO1 HOMER3 CD34 OLIG2 SOX10 SLC17A6 SLC17A7 GABBR2 SLC18A3 SYP CLDN11 TNC ERAS KLF4 HOMER1 GRIN2B GRIN1 DLG4 AQP4 SHANK3 TPM1 TBXT PIG59 CSPG4 ADRA2C ADRA2B SLC1A2 ADRA2A SLC1A3 SNAI1 PECAM1 SNAI2 RIMS2 BSN RBFOX3 NLGN1 FBXO15 AP2A1 TBR1 CACNG2 TWIST2 AP2A2 LIN7A FUT4 CD24 PCLO ERC1 DPPA2 GLRA1 GLRA2 KCNJ6 SOX2 GLRA3 SOX17 CASK HES3 S100B GLRB RIMBP2 SLC6A5 GATA6 SLC6A9 NOTCH1 GAD1 FGF4 HNF4A DPPA3 ZFP42 BMP4 LEF1 NEF3 POU5F1 ACHE SLC6A2 SLC6A3 NEFL CNP MIXL1 MOG FOXA2 ChAT TH UNC13A SOX9 ITGA6 FOXD3 MSX2 HOMER2 PAX3 ITGB1 CDH2 FEV SHANK1 HES1 MBP HES5 GLS GAD2 PYRIMIDINE METABOLISM AND RELATED DISEASES%WIKIPATHWAYS_20260710%WP4225%HOMO SAPIENS Pyrimidine metabolism and related diseases HEL74 CAD DPYS TYMP RRM1 ABAT RRM2B OTC DPYD GLS2 TYMS UMPS DHODH RRM2 NT5C3A AGXT2 MITOCHONDRIAL BETA OXIDATION%WIKIPATHWAYS_20260710%WP5241%HOMO SAPIENS Mitochondrial beta oxidation ECHS1 HSD17B10 ACADSB ACSL3 ACADL EHHADH DECR1 ALTERED GLYCOSYLATION OF MUC1 IN TUMOR MICROENVIRONMENT%WIKIPATHWAYS_20260710%WP4480%HOMO SAPIENS Altered glycosylation of MUC1 in tumor microenvironment NFKBIA CHUK IKBKB RELA IKBKG NFKB1 IL6 TNF MUC1 BDNF SIGNALING IN NEURODEVELOPMENT%WIKIPATHWAYS_20260710%WP5541%HOMO SAPIENS BDNF signaling in neurodevelopment NFKBIA NGFR SORT1 GRB2 YWHAQ ARHGAP35 PARD3 PRKCA ARHA EIF4E STAT3 MAPKAPK2 LINGO1 PARD6A PRKCE EEF2 EEF2K HEL-S-15 FRS2 GSK3B PLCG1 RAC1 BMP7 PIK3CD NRAS EIF4EBP1 CREB1 NTRK2 BDNF RAF1 PIK3CA TIAM1 SMPD1 PAK1 MAPK1 RPS6KB2 HEL2 MAPK3 PRKCB CFL2 TRADD MTOR CASP9 CASP8 RPS6KB1 CYCS FADD NPTX2 DOCK7 IQGAP3 MAPK8 BCL2L11 SH2B2 KIDINS220 MAP3K5 HEL-S-1 YWHAG MAP2K4 JUN IRS1 MYC FOXO3A MAPK11 TRAF6 PTPN11 BCL2 LEF1 BAX TCF7L2 TCF7L1 MAP3K1 APAF1 BAD PRKCI PRKCH HRAS PRKCZ MAP2K1 MAP2K2 TP73 PDPK1 CHUK RTN4R IKBKB RAPGEF1 IKBKG SOS1 CRK LIMK1 SHC1 HEL-S-93 ROCK1 MAPK7 ROCK2 MAP2K5 WASL PARD6B HEL-S-47e CDC42 SMITH MAGENIS AND POTOCKI LUPSKI SYNDROME COPY NUMBER VARIATION%WIKIPATHWAYS_20260710%WP5381%HOMO SAPIENS Smith Magenis and Potocki Lupski syndrome copy number variation IFT74 RMND5A MLST8 HES6 RANBP9 PARD3 MKLN1 GID4 TNFRSF13B ATPAF2 ARHA CLUAP1 CLTB TLR4 STAT3 RAB10 CRY2 MAP3K14 CLTA SHMT1 CARM1 PCK1 YAP1 WWTR1 HEL-S-133P MED9 ETV5 APP G6PC1 IRF8 TNF RPTOR PRKAA1 PTEN RRAGA PRKAG2 FOXA1 CREB1 PRKAB1 NR1H2 BLM NR1H3 ULK1 RAI1 FLII GRIP1 TNFSF13 RELA MYH2 TRAF3IP1 PPP1R14A IFT172 MAEA CFL2 IFT80 ARMC8 MTOR IFT81 FHOD1 FERD3L COPS7A ALKBH5 DENR RB1CC1 MIGA1 TOM1L2 CDC2 LLGL1 DRC5 BCL2L11 DRC7 DRC8 CLEC16A PLD6 RAB39B GDI2 CRY1 WDR41 ARG2 RMI2 RMI1 JUN DRC1 TOP3A ITPK1 DRC10 SMCR8 COPS4 FLCN GPS1 IFT20 MIEF2 COPS6 RASD1 ATG101 IFT22 FNIP1 PEMT FNIP2 COPS5 MYO16 MYC MYO15A DRG2 IFT27 COPS8 IFT25 BAX PER1 TTC26 C9orf72 IFT52 BIRC2 GPR85 IFT57 FOXA2 RNF41 RAB8A IL1B PRKCI NFKB1 CLTC BCL6 PARK2 IFT46 LIMK1 TFEB IFT70B ROCK1 WDR26 PARD6B MYD88 WHITE FAT CELL DIFFERENTIATION%WIKIPATHWAYS_20260710%WP4149%HOMO SAPIENS White fat cell differentiation IRF4 FOXO1 CTNNA1 EGR2 ZNF423 RARA IRF3 WNT10B NR3C1 TCF7L1 RORA KLF5 KLF2 INS DDIT3 CEBPB CEBPD EVI1 PPARG TLE3 KLF4 CREB1 NR2F2 GATA3 NR1H3 GATA2 CEBPA KLF15 STAT5B OMEGA 9 FATTY ACID SYNTHESIS%WIKIPATHWAYS_20260710%WP4724%HOMO SAPIENS Omega 9 fatty acid synthesis ELOVL5 ELOVL2 ACSL1 FACL4 ELOVL3 ACSL3 FADS2 FADS1 SCD FASN ELOVL1 SCD5 ELOVL6 MAPK PATHWAY IN CONGENITAL THYROID CANCER%WIKIPATHWAYS_20260710%WP4928%HOMO SAPIENS MAPK pathway in congenital thyroid cancer MAP2K2 SOS2 KSR1 MAPK3 SOS1 RAF1 JUN SHC1 FOS GAREM2 MYC ALK MAP2K1 NAD METABOLISM IN ONCOGENE INDUCED SENESCENCE AND MITOCHONDRIAL DYSFUNCTION ASSOCIATED SENESCENCE%WIKIPATHWAYS_20260710%WP5046%HOMO SAPIENS NAD metabolism in oncogene induced senescence and mitochondrial dysfunction associated senescence NMNAT2 SLC2A4 GOT2 HEL-S-32 CCL27 PRKAA1 RELA NAMPT IL1B HMGA1 IL6 SIRT5 SIRT1 ELAVL1 SIRT3 MDH2 SIRT2 COVID 19 ADVERSE OUTCOME PATHWAY%WIKIPATHWAYS_20260710%WP4891%HOMO SAPIENS COVID 19 adverse outcome pathway ACE2 TMPRSS2 IL10 TNF IL2RA IL2 IL1B CCL3 CSF3 CXCL8 IL6 IL7 CCL2 PROSTAGLANDIN SYNTHESIS AND REGULATION%WIKIPATHWAYS_20260710%WP98%HOMO SAPIENS Prostaglandin synthesis and regulation S100A10 PTGIS ANXA3 HPGD ANXA4 SCGB1A1 PTGS2 PTGS1 PPARGC1A PTGES CYP11A1 S100A6 PRL EDN1 ANXA6 PPARG PPARGC1B PTGER4 PTGER1 SOX9 EDNRA PTGER2 PTGER3 EDNRB PTGIR PTGDR PTGFR TBXA2R AKR1C1 AKR1C2 AKR1B1 HSD11B1 ANXA1 HSD11B2 HEL-S-7 PTGFRN ANXA2 STATIN INHIBITION OF CHOLESTEROL PRODUCTION%WIKIPATHWAYS_20260710%WP430%HOMO SAPIENS Statin inhibition of cholesterol production PLTP APOE APOB ABCA1 SCARB1 ABCG8 ABCG5 APOC1 FDFT1 HMGCR CYP7A1 LDLR APOC3 SQLE SOAT1 DGAT1 PDIA2 MTTP APOA2 LPL APOA4 APOA5 LIPC APOC2 ACSS1 ONCOSTATIN M SIGNALING%WIKIPATHWAYS_20260710%WP2374%HOMO SAPIENS Oncostatin M signaling OSMR VEGFA NFKBIA OSM CDK2 MAPK3 GRB2 JUND PRKCB PRKCA MTOR CASP3 EGR1 CEBPB STAT3 MAPK8 RICTOR JUNB PRKCE PTK2B CDKN1B IRS1 FOS MAPK14 SOCS3 JAK1 JAK3 STAT5B PTPN11 TYK2 MAPK9 IL6ST STAT1 RPS6 PRKCH NFKB1 HRAS PIK3R1 MAP2K1 MAP2K2 CREB1 SOS1 RAF1 SHC1 SRC PXN HIF1A RELA MAPK1 ZINC HOMEOSTASIS%WIKIPATHWAYS_20260710%WP3529%HOMO SAPIENS Zinc homeostasis MT1M SLC30A10 SLC30A7 SLC30A6 SLC30A9 SLC30A8 SLC30A2 SLC30A5 SLC30A4 SLC30A1 SLC39A2 SLC39A9 SLC39A1 SLC39A6 SLC39A3 SLC39A5 SLC39A8 SLC39A14 MT2A SLC39A11 SLC39A10 SLC39A13 SLC39A12 MT4 MT3 MT1A MTF1 MT1F MT1G MT1B MT1E MIRNA REGULATION OF DNA DAMAGE RESPONSE%WIKIPATHWAYS_20260710%WP1530%HOMO SAPIENS miRNA regulation of DNA damage response CCNE2 CDK2 CCNG1 PIDD1 CHEK2 CHEK1 CASP9 CASP8 CASP3 CYCS PRKDC SESN1 PML RAD17 CCNB3 RB1 HUS1B CDKN1A BRCA1 TP53AIP1 TLK1 SFN GADD45B CDC2 GADD45G ATR CDKN1B BBC3 CCND3 CCND2 RFC1 MYC DDB2 BAX PMAIP1 RAD52 RAD50 RAD51 CDK5 MRE11A CCND1 NBN RRM2B APAF1 GADD45A TNFRSF10B SMC1A FANCD2 MDM2 ATM CREB1 CDK6 CDK4 RAD1 CCNE1 ATRIP CCNB2 CCNB1 H2AX RAD9A TLK2 BMP2 WNT4 FOXO1 PATHWAY IN PRIMARY ENDOMETRIAL STROMAL CELL DIFFERENTIATION%WIKIPATHWAYS_20260710%WP3876%HOMO SAPIENS BMP2 WNT4 FOXO1 pathway in primary endometrial stromal cell differentiation DKFZp781O1323 DCN SFRP1 BCL2L11 BMP2 DKK1 FOXO1 SMAD1 SMAD9 LEFTY2 WNT4 SST PROSTAGLANDIN AND LEUKOTRIENE METABOLISM IN SENESCENCE %WIKIPATHWAYS_20260710%WP5122%HOMO SAPIENS Prostaglandin and leukotriene metabolism in senescence ALOX15 PTGIS ALOX12 LTC4S PTGS2 ALOX15B PTGS1 GNAI1 PTGES IGFBP5 ALOX5AP HRAS PRXL2B RB1 SIRT1 NRAS CDKN1A PTGER4 PTGER1 GNAS ADCY3 PTGER2 PTGER3 MAPK11 ALOX5 MIRNAS INVOLVED IN DNA DAMAGE RESPONSE%WIKIPATHWAYS_20260710%WP1545%HOMO SAPIENS miRNAs involved in DNA damage response CDKN1A H2AX ATM CDK6 CREB1 CCND1 CCNE1 CCND3 MYC RAD52 CDKN1B REGUCALCIN IN PROXIMAL TUBULE EPITHELIAL KIDNEY CELLS%WIKIPATHWAYS_20260710%WP4838%HOMO SAPIENS Regucalcin in proximal tubule epithelial kidney cells BAX PTH TGFBR1 SMAD2 SEC16B HEL-S-41 PDE1B MTOR TRPV5 CASP9 SMAD4 CASP8 CASP3 APAF1 MCU PPP3R1 TNFSF11 BAK1 FFAR3 MAP3K5 CALCA RAF1 PIK3CA TGFB1 ACTA2 TNFRSF1A MAPK1 QUERCETIN AND NF KB AP 1 INDUCED APOPTOSIS%WIKIPATHWAYS_20260710%WP2435%HOMO SAPIENS Quercetin and Nf kB AP 1 induced apoptosis VEGFA NFKBIA IKBKB KEAP1 PTGS2 MAFG JUN FOS COX1 NFKB1 CYP2A6 MAFK NFE2L2 SULFATION BIOTRANSFORMATION REACTION%WIKIPATHWAYS_20260710%WP692%HOMO SAPIENS Sulfation biotransformation reaction SULT2B1 SULT6B1 PAPSS2 SULT1C4 SULT1B1 SULT1E1 SULT1A1 PAPSS1 SULT1A4 HEL-75 SULT1A2 SULT2A1 SULT1C3 SULT1C2 INTERACTIONS BETWEEN IMMUNE CELLS AND MICRORNAS IN TUMOR MICROENVIRONMENT%WIKIPATHWAYS_20260710%WP4559%HOMO SAPIENS Interactions between immune cells and microRNAs in tumor microenvironment PDCD1 IRAK4 TGFBR2 TLR7 TLR8 IL4 TGFB1 CD80 CTLA4 IL2RA IL2RB IL2RG NFKB1 SOCS1 NFKB2 TRAF6 CCL5 STAT3 CCL2 TLR4 PEROXISOMAL BETA OXIDATION OF TETRACOSANOYL COA%WIKIPATHWAYS_20260710%WP1941%HOMO SAPIENS Peroxisomal beta oxidation of tetracosanoyl CoA HSD17B4 ACOX1 ETHYLMALONIC ENCEPHALOPATHY%WIKIPATHWAYS_20260710%WP5030%HOMO SAPIENS Ethylmalonic encephalopathy SUOX ETHE1 BETA GLOBIN GENE EXPRESSION REGULATION%WIKIPATHWAYS_20260710%WP5606%HOMO SAPIENS Beta globin gene expression regulation tal-1 HBG2 LDB1 HBG1 LMO2 HBE1 KDM1A GATA1 GATAD2B PPARGC1A HBB HBD KLF1 ZFPM1 HDAC2 ZBTB7A HDAC1 CHD3 MYB MTA2 NR2C2 EICOSANOID METABOLISM VIA CYCLOOXYGENASES COX %WIKIPATHWAYS_20260710%WP4719%HOMO SAPIENS Eicosanoid metabolism via cyclooxygenases COX PTGIS HPGD ACOX1 PLA2G4B PTGS2 PTGS1 EHHADH ACOX3 PTGES PTGDR2 HEL-S-298 PRXL2B PTGR1 PPARG CYP4A11 CYP4F2 CYP4F12 NR1C2 PTGIR PTGDR PTGFR PLA2G5 TBXA2R AKR1B1 PLA2G6 CYP4A22 LIDOCAINE METABOLISM%WIKIPATHWAYS_20260710%WP2646%HOMO SAPIENS Lidocaine metabolism CYP1A2 CYP3A4 EXERCISE AND HYPERTROPHY IN SKELETAL MUSCLE%WIKIPATHWAYS_20260710%WP516%HOMO SAPIENS Exercise and hypertrophy in skeletal muscle VEGFA EIF4EBP1 DUSP14 HBEGF IL1A JUND ANKRD1 CYR61 MYOG IL1R1 IFRD1 ADAM10 NR4A3 MSTN HEL-S-52 EIF4E IL18 ATF3 IFNG GLYCINE METABOLISM INCLUDING IMDS%WIKIPATHWAYS_20260710%WP5028%HOMO SAPIENS Glycine metabolism including IMDs AMT DLD GLDC SHMT1 LIPT2 LIPT1 HSCB LIAS NFU1 GCSH BOLA3 ISCU HEL-S-302 REGULATION OF ACTIN CYTOSKELETON%WIKIPATHWAYS_20260710%WP51%HOMO SAPIENS Regulation of actin cytoskeleton PS1TP5BP1 ARHGAP35 CD14 ARPC5 MYLK ARHA EZR F2 IQGAP1 HEL-S-15 VAV1 FGFR1 GNA13 ARHGEF1 FGF8 FGFR3 CHRM3 RDX EGF FGF16 RAC1 PIK3CD PIK3R3 PIK3R1 NRAS FGF19 FGF21 FGFR4 RAF1 PFN1 PIK3CA ARHGEF7 GNG12 ACTN1 MYL1 PAK1 MYL3 F2R MAPK1 TMSB4X MAPK3 CHRM2 CHRM1 FGF3 RRAS2 FGF6 FGF9 CFL2 FGF20 FGF22 FGF17 RRAS FGF14 FGF23 FGF18 FGF13 EGFR BAIAP2 FGF12 FGF7 ARHGEF4 BDKRB2 BDKRB1 PDGFRA PIP5K1A PIK3C2G PIK3C2B PDGFA FGF4 CHRM4 CHRM5 SOS2 PIP4K2A PIP4K2B PIK3R4 FGF10 PIK3R5 PIP5K1C MOS WASF1 HEL114 APC2 HEL70 RAC3 FGF2 APC NCKAP1 MYH10 MAP2K1 RASSF7 MAP2K2 SSH2 SSH3 SSH1 BRK1 PIP5KL1 ITGA1 FGFR2 FGD1 WASF2 ABI2 STM7 SOS1 CRK DOCK1 LIMK1 PXN PIK3R2 ROCK1 ROCK2 PAK6 CSK WAS MAPK6 MAPK4 CYFIP2 PAK4 ACTG1 CDC42 SARS COV 2 MITOCHONDRIAL CHRONIC OXIDATIVE STRESS AND ENDOTHELIAL DYSFUNCTION%WIKIPATHWAYS_20260710%WP5183%HOMO SAPIENS SARS CoV 2 mitochondrial chronic oxidative stress and endothelial dysfunction ACE2 ECSIT NDUFAF2 MITA NDUFAF1 TERF2 REN TNF RPS6KA1 NLRP3 SIRT6 TOMM70 ACAD9 TRAF3 NLRX1 MAVS NFKB1 IL18 IL6 TERF2IP TRAF6 MELANOMA%WIKIPATHWAYS_20260710%WP4685%HOMO SAPIENS Melanoma PDE5A MAPK3 GRB2 GRM3 ARHA CALM1 RB1 CDKN1A GADD45B ERBB4 GADD45G BAK1 CDKN2A KIT E2F2 E2F3 DDB2 PTPN11 SOS2 POLK BAX ARAF HEL114 CCND1 AKT3 KDR GADD45A RAC1 BAD PTEN PIK3CD PIK3R3 HRAS PIK3R1 MAP2K1 NRAS MAP2K2 MDM2 CDK6 CDK4 CALML6 PREX2 CALML3 WHR1 CALML4 SHC2 SOS1 RAF1 PIK3CA NF1 RHOB PIK3R2 EXOC7 PAK1 MAPK1 PROLACTIN SIGNALING%WIKIPATHWAYS_20260710%WP2037%HOMO SAPIENS Prolactin signaling NFKBIA MAPK3 GRB2 FYN ZAP70 PPIB MTOR CASP3 SOCS2 RPS6KB1 PRL CISH SIRPA STAT3 MAPK8 TEC YWHAG JUN IRS1 VAV1 FOS MAPK14 NFKBIB PTPN6 CBL MYC SOCS3 SOCS1 JAK1 FLNA STAT5B PTPN11 GAB2 MAPK9 ERBB2 PRLR STAT1 GSK3B HEL-S-130P RAC1 RPS6 NFKB1 HRAS PIK3R1 MAP2K1 MAP2K2 AGAP2 EIF4EBP1 RPS6KA2 VAV2 HEL-S-69p NEK3 SOS1 RAF1 PIK3CA SHC1 SRC PXN ITGB1 PIK3R2 HEL-S-93 RELA PAK1 PTPN1 MAPK1 RETINOBLASTOMA GENE IN CANCER%WIKIPATHWAYS_20260710%WP2446%HOMO SAPIENS Retinoblastoma gene in cancer FAF1 CCNE2 CDK2 SMC3 CHEK1 PRIM1 SKP2 CDT1 POLA1 CDC25B PRMT2 HDAC1 PRKDC RBBP4 RRM2 ZNF655 RB1 H2AZ1 CDKN1A CDC2 MCM7 ORC1L PLK4 CDKN1B TFDP1 HMGB1 POLE TFDP2 MCM3 RFC3 RFC4 MCM6 CCND3 RBP1 TTK MAPK13 MYC CCNA2 CDC45 E2F2 E2F3 WEE1 HMGB2 TOP2A POLE2 RPA3 POLD3 RRM1 RPA1 CCND1 BARD1 MSH6 SMC1A MDM2 PCNA CDK6 CDK4 CCNE1 RBBP7 FANCG RAF1 CCNB2 SMC2 SAP30 CCNB1 NPAT HLTF TYMS DHFR SUV39H1 CCDC6 SIN3A HIPK2 IN KIDNEY FIBROSIS%WIKIPATHWAYS_20260710%WP4751%HOMO SAPIENS HIPK2 in kidney fibrosis SIAH1 HIPK2 PROSTAGLANDIN SIGNALING%WIKIPATHWAYS_20260710%WP5088%HOMO SAPIENS Prostaglandin signaling VEGFA CXCL9 TNF PTGES AREG CCR2 IFNA1 CCL3 IL1B AHR CSF1 NFKB1 CXCL8 CXCL1 CCL2 PYCARD PTGER4 IL1A IRF7 IL17F PTGER2 TGFB1 IL17A KLRD1 NLRP3 IL12A IL6 IFNG MMP9 OSTEOBLAST DIFFERENTIATION AND RELATED DISEASES%WIKIPATHWAYS_20260710%WP4787%HOMO SAPIENS Osteoblast differentiation and related diseases MAPK10 HES6 LRP6 PRKCA RBPJ FZD1 FZD7 FZD8 PRKD1 FZD2 JAG2 DLL3 PRKCE PRKCQ FGFR1 FGF8 GLI3 FGFR3 SMO BMPR1A STAT1 FZD9 WNT9B PIK3CD FZD10 PIK3R3 NOTCH3 NOTCH4 WNT9A DLL4 PIK3R1 WNT8B FGFR4 PIK3CA MAPK1 MAPK3 FGF3 FGF6 PRKCB FGF9 MYOD1 PRKDC BMPR2 HES3 FGF18 DKFZp781O1323 MAPK8 FGF7 RUNX2 FZD5 FZD4 NOTCH1 WNT2B LRP5 PIK3C2G PTCH1 PIK3C2B MAPK14 MAPK12 MAPK13 SMAD1 MAPK11 SMAD9 WNT5B FGF4 WNT16 BMP4 PIK3R4 FGF10 PIK3R5 MAPK9 BMP2 WNT1 WNT3 WNT4 WNT10B WNT10A SMAD4 WNT3A WNT7B PRKCI WNT7A FGF2 PRKCH PRKCZ PPARG FGFR2 HEY2 SOX9 HES2 PIK3R2 MAPK7 NOTCH2 WNT8A MAPK6 MAPK4 FZD3 GENES RELATED TO PRIMARY CILIUM DEVELOPMENT BASED ON CRISPR %WIKIPATHWAYS_20260710%WP4536%HOMO SAPIENS Genes related to primary cilium development based on CRISPR IFT74 CEP76 TUBE1 DYNC2I2 CPLANE2 SASS6 TRAF3IP1 RABL2B CEP162 IFT172 CIBAR1 CEP44 CEP97 TTC8 IFT80 LZTFL1 KIAA0753 OFD1 IFT81 DNCL1 CEP20 CLUAP1 TCTN3 TCTN2 TCTN1 CC2D2A ARMC9 TMEM216 CEP104 WDPCP ARL3 BBS2 ARL13B ARL6 TMEM67 INPP5E BBS1 PIBF1 CPLANE1 TMEM231 TMEM17 FUZ C2CD3 B9D1 TMEM107 IFT20 MKS1 BBS10 BBS12 IFT27 CCDC41 IFT25 TTC26 MIB1 IFT52 RAB23 BBS9 KIF3A BBS7 EVC2 IFT57 CEP192 SCLT1 BBS5 EVC WDR35 DYNLT1 IFT140 BBS4 IFT43 IFT46 RPGRIP1L TTC23 CBY1 EFCAB7 IFT70B TXNDC15 DYNC2H1 CDK20 TRAPPC11 KIFAP3 CEP295 CEP19 TEDC1 TEDC2 FBF1 DYNLT2B DYNC2LI1 KATNB1 TUBD1 KIF3B PERTURBED THYROID HORMONE HOMEOSTASIS LEADING TO DEVELOPMENTAL NEUROTOXICITY%WIKIPATHWAYS_20260710%WP5517%HOMO SAPIENS Perturbed thyroid hormone homeostasis leading to developmental neurotoxicity SLC7A5 SLCO3A1 SLCO4A1 SLCO1C1 SLCO1A2 SLC16A2 SLC16A10 HOST PATHOGEN INTERACTION OF HUMAN CORONAVIRUSES APOPTOSIS%WIKIPATHWAYS_20260710%WP4864%HOMO SAPIENS Host pathogen interaction of human coronaviruses apoptosis BCL2 BAX BCL2L1 BCL2L11 MCL1 TNF CASP9 CASP8 APAF1 BBC3 CASP3 MAPK14 BAD MAPK12 FADD MAPK13 MAPK11 TNFSF6 BLOOD BASED NEUROINFLAMMATION MARKERS %WIKIPATHWAYS_20260710%WP5548%HOMO SAPIENS Blood based neuroinflammation markers CHI3L1 GRN GFAP BDNF OLR1 PBR TNF NEFL CCL23 CRP DBI ADM IL1B S100B CX3CL1 IL6 CCL11 CCL5 TREM1 CCL2 EVOLOCUMAB MECHANISM TO REDUCE LDL CHOLESTEROL%WIKIPATHWAYS_20260710%WP3408%HOMO SAPIENS Evolocumab mechanism to reduce LDL cholesterol PCSK9 LDLR OSX AND MIRNAS IN TOOTH DEVELOPMENT%WIKIPATHWAYS_20260710%WP3971%HOMO SAPIENS OSX and miRNAs in tooth development KLF4 SOST DKK1 RUNX2 DSPP SP7 NOTCH1 HNF1A NOTCH2 DMP1 BMP7 ALPL NOTCH3 NOTCH4 LINOLEIC ACID OXYLIPIN METABOLISM%WIKIPATHWAYS_20260710%WP5137%HOMO SAPIENS Linoleic acid oxylipin metabolism ALOX15 EPHX2 ALOX5 ACETYLCHOLINE SYNTHESIS%WIKIPATHWAYS_20260710%WP528%HOMO SAPIENS Acetylcholine synthesis ACHE ChAT PEMT PDHA2 PDHA1 CHKA MICRORNA NETWORK ASSOCIATED WITH CHRONIC LYMPHOCYTIC LEUKEMIA%WIKIPATHWAYS_20260710%WP4399%HOMO SAPIENS MicroRNA network associated with chronic lymphocytic leukemia BCL2 ZAP70 MCL1 NIPBL ROLE IN DNA DAMAGE CORNELIA DE LANGE SYNDROME%WIKIPATHWAYS_20260710%WP5119%HOMO SAPIENS NIPBL role in DNA damage Cornelia de Lange syndrome NIPBL H2AX ATM CBX3 MDC1 RNF168 ATR RNF8 ACE INHIBITOR PATHWAY%WIKIPATHWAYS_20260710%WP554%HOMO SAPIENS ACE inhibitor pathway CMA1 ACE2 CTSG KNG1 BDKRB2 AGTR1 BDKRB1 REN AGTR2 TGFB1 CYP11B2 MAS1 NR3C2 ATP6AP2 POLYOL PATHWAY%WIKIPATHWAYS_20260710%WP690%HOMO SAPIENS Polyol pathway SORD KHK AKR1B1 ALDOB HEAD AND NECK SQUAMOUS CELL CARCINOMA%WIKIPATHWAYS_20260710%WP4674%HOMO SAPIENS Head and neck squamous cell carcinoma VEGFA RPS6KB2 MLST8 IRF6 CSMD3 SESN2 DDIT4 MTOR CASP8 FAT1 FADD SESN1 EIF4E NFE2L2 RB1 CDKN1A EGFR IGF1R MAPKAP1 STK11 RICTOR NOTCH1 CDKN2A TP63 FGFR1 AJUBA FGFR3 PIK3R5 TGFBR2 ERBB2 KEAP1 BIRC2 TERT RPTOR TSC2 SMAD4 CCND1 AKT3 PRKAA1 FKBP1A PRKAA2 PTEN MAML1 RPS6 TRAF3 TSC1 NFKB1 NFKB2 HRAS PIK3R1 NRAS EIF4EBP1 PDPK1 NUMB CDK6 CDK4 PIK3CA RHEB PIK3R2 RELA NOTCH2 LTBR REL ARYL HYDROCARBON RECEPTOR PATHWAY%WIKIPATHWAYS_20260710%WP2873%HOMO SAPIENS Aryl hydrocarbon receptor pathway POLK BAX NCOA1 JUND MGST1 TNF UGT1A1 CAP2 EP300 NQO1 SERPINB2 IGFBP1 IL1B AHR ALDH3A1 CES3 NFE2L2 IL12B EGFR JUNB CDC37 TGFB1 IL17B CDKN1B JUN UGT1A4 SRC IL12A UGT1A3 UGT1A9 CYP1A2 CYP1A1 AHRR UGT1A7 SLC7A5 IL2 PTGES3 CYP1B1 MYOF AIP HES1 IFNG INFLAMMATORY BOWEL DISEASE SIGNALING%WIKIPATHWAYS_20260710%WP5198%HOMO SAPIENS Inflammatory bowel disease signaling RORC STAT4 TNF SMAD2 STAT1 RORA IL12RB1 NFKB1 IL-21 IL18RAP TLR5 NOD2 STAT3 TLR4 MAF IFNGR1 IL13 FOXP3 IL1A GATA3 IL22 IL23A IL17F IL10 IL4 IL5 TGFB1 JUN IL12A IL21R HLA-DMA IL2 IL23R IL2RG TBX21 IL18 IL6 NFATC1 IFNG SPHINGOLIPID METABOLISM OVERVIEW%WIKIPATHWAYS_20260710%WP4725%HOMO SAPIENS Sphingolipid metabolism overview DEGS2 SPTLC1 PLPP3 PLPP2 CERS3 SPHK2 SPHK1 CERS6 CERK SGMS1 LASS1 UGT8 SGMS2 SGPP1 UGCG SGPP2 GBA2 DEGS1 KDSR SGPL1 SPTLC2 CERS2 SMPD1 PLPP1 DNAJB1 PRKACA FUSION IN FIBROLAMELLAR LIVER CANCER%WIKIPATHWAYS_20260710%WP5514%HOMO SAPIENS DNAJB1 PRKACA fusion in fibrolamellar liver cancer CREB1 CRTC2 SIK1 HDAC5 GNAS SIK3 SIK2 DNAJB1 HDAC7 MAMMARY GLAND DEVELOPMENT EMBRYONIC DEVELOPMENT STAGE 1 OF 4%WIKIPATHWAYS_20260710%WP2813%HOMO SAPIENS Mammary gland development embryonic development stage 1 of 4 CLDN4 ERBB4 ZEB2 ITGA6 TNF NRG3 TGFB1 TERT CCND1 ITGB1 SFRP1 ALPL MYC MITOCHONDRIAL COMPLEX III ASSEMBLY%WIKIPATHWAYS_20260710%WP4921%HOMO SAPIENS Mitochondrial complex III assembly UQCRQ UQCC CYB UQCC3 UQCRFS1 UQCC2 TTC19 LYRM7 UQCRC1 UQCRC2 UQCRB UQCR11 UQCR10 UQCRH CYC1 TUMOR SUPPRESSOR ACTIVITY OF SMARCB1%WIKIPATHWAYS_20260710%WP4204%HOMO SAPIENS Tumor suppressor activity of SMARCB1 DPF1 DPF3 SUZ12 ACTL6A SMO SMARCE1 ACTL6B SMARCA4 GLI4 DPF2 RBBP4 RB1 CDK6 SMARCC1 CDK4 SMARCC2 H3F3B ARID1A ARID1B SMARCD1 EED SMARCD2 CDKN2A SMARCD3 PTCH1 EZH2 GLI3 GROWTH FACTORS AND HORMONES IN BETA CELL PROLIFERATION%WIKIPATHWAYS_20260710%WP5385%HOMO SAPIENS Growth factors and hormones in beta cell proliferation TGFBR1 CDK4 IGF1R CDK2 CRTC2 MAPK3 FOXO1 FOXM1 RASSF1 RAB43 AKT3 FLT1 INSR PDX1 MYC INS PDGFA IGF1 MAPK1 TRANSCRIPTIONAL CASCADE REGULATING ADIPOGENESIS%WIKIPATHWAYS_20260710%WP4211%HOMO SAPIENS Transcriptional cascade regulating adipogenesis KLF5 GATA2 CEBPA GATA3 EGR2 KLF2 CEBPG KLF15 DDIT3 CEBPB CEBPD PPARG ALZHEIMER 39 S DISEASE AND MIRNA EFFECTS%WIKIPATHWAYS_20260710%WP2059%HOMO SAPIENS Alzheimer 39 s disease and miRNA effects TUBA3E TUBA1C TUBB6 AGER TUBA1B TUBA1A TUBB1 LRP6 TUBB ATF4 FZD1 CSNK1A1 TUBB4B TUBB4A FZD7 TUBA4A TUBB2A FZD8 PPP3CA SFRP4 TUBA2 FZD2 TUBA8 SLC25A6 NOX4 ADAM10 PSENEN BACE1 APP PSEN2 PSEN1 FZD9 XBP1 FZD10 SNCA EIF2S1 INS ERN1 DDIT3 CHRNA7 IRS4 NOS2 VDAC3 EIF2AK2 RYR3 LPL PSMD7 ITPR2 CASP9 CASP8 CASP3 CYCS FADD CSF1 PSMD12 PSMD13 RB1CC1 DKK1 LRP5 AMBRA1 ATG101 ADAM17 WIPI1 ARAF GPR83 AKT3 PSMD2 HRAS PPP3CC MAP2K1 MAP2K2 RTN4 hCG_2014051 AXIN2 PIK3R2 HEL-S-91n FZD3 MAPK10 CSNK2B PTGS2 PSMC6 PSMC4 CASP12 PPP3R1 PPP3R2 HEL-S-162eP SLC25A5 HEL-S-61 PSMD9 PSMD6 PSMD4 PSMD3 PSMD1 DKK2 CYBB NRBF2 ATG2B WIPI2 PSMA4 ATG14 PSMA2 KNS2 PSMA8 PSMB6 ATG2A PSMB2 PSMB3 PSMC1 TNF CDK5R1 HEL-S-276 PPIF RTN3 CDK5 SLC25A4 KLC4 KLC3 KLC2 NAE1 GSK3B SHFM1 MCU ATP2A1 ADRM1 DKK4 PIK3CD SLC25A31 PIK3R3 ULK2 CACNA1C PIK3R1 APH1B NRAS GRIN2B CALML6 GRIN1 CALML3 CALML4 ULK1 RAF1 PIK3CA ATP2A2 RELA MAPK1 APOE CACNA1F MAPK3 HSD17B10 KIF5A CACNA1S MTOR PLCB3 PLCB4 PLCB1 PLCB2 CALM1 MAPK8 IL1A MAP3K5 FZD5 WNT2B IRS1 TRAF2 FRAT1 TNFRSF1A IL6 WNT5B AXIN1 WNT16 PIK3R4 MAPK9 DVL1 DVL2 DVL3 FRAT2 WNT1 WNT3 WNT4 WNT10B APC2 CSNK1A1L WNT10A APAF1 BAD WNT3A IL1B WNT7B INSR WNT7A NFKB1 APC CHUK IKBKB CSNK2A1 CSNK2A3 CSNK2A2 TUBAL3 BECN2 MME TUBB8 AEROBIC GLYCOLYSIS AUGMENTED%WIKIPATHWAYS_20260710%WP4628%HOMO SAPIENS Aerobic glycolysis augmented HEL-S-30 HEL-S-87p HEL-S-133P GPT PGAM2 ENO1 HEL-S-68p HEL-S-49 HEL-S-162eP PFKM TH17 CELL DIFFERENTIATION PATHWAY%WIKIPATHWAYS_20260710%WP5130%HOMO SAPIENS Th17 cell differentiation pathway NFKBIA ZAP70 RUNX1 LCK MTOR NFIL3 PPP3CA IL27 STAT3 MAPK8 IFNGR1 FOXP3 GATA3 IL22 CRY1 CD3G JUN CD3E FOS PRKCQ MAPK14 HLA-DMA IL2 LAT SOCS3 TBX21 JAK1 IL6 IFNG NFATC1 TYK2 RORC PER1 IL6R TGFBR1 IRF4 RARA SMAD2 STAT1 RORA PLCG1 IL1B AHR NFKB1 IL-21 CD3D IKBKB RXRA IL23A IL17F IL4 NR1D1 TGFB1 IL17A IL21R HIF1A IL2RA IL23R IL27RA MAPK1 KYNURENINE PATHWAY AND LINKS TO CELL SENESCENCE%WIKIPATHWAYS_20260710%WP5044%HOMO SAPIENS Kynurenine pathway and links to cell senescence CDKN1A AADAT FOXO1 IFNB1 IL1R2 TNF HAAO TDO2 KYNU AFMID KMO KLF5 EIF2AK4 IDO2 HEL-S-90n IDO1 AHR EIF2AK1 IFNG TLR4 NAD METABOLISM SIRTUINS AND AGING%WIKIPATHWAYS_20260710%WP3630%HOMO SAPIENS NAD metabolism sirtuins and aging HIF1A NAMPT FOXO1 FOXO3A NFKB1 ROS1 SIRT1 SIRT3 TFAM PPARG FLT3 P GLN640SERFSTER8 SIGNALING%WIKIPATHWAYS_20260710%WP5431%HOMO SAPIENS FLT3 p Gln640SerfsTer8 signaling CCR6 CCR5 FLT3 STAT3 TRANSCRIPTIONAL ACTIVATION BY NRF2 IN RESPONSE TO PHYTOCHEMICALS%WIKIPATHWAYS_20260710%WP3%HOMO SAPIENS Transcriptional activation by NRF2 in response to phytochemicals HMOX1 MAF MAPK8 KEAP1 PIK3CA PRKCA NQO1 AIMP2 GCLC GCLM EPHB2 NFE2L2 CEBPB SLC7A11 COCAINE METABOLISM%WIKIPATHWAYS_20260710%WP2826%HOMO SAPIENS Cocaine metabolism CES2 CYP3A4 CES1 BCHE MSMP EXPRESSION REGULATION IN CANCER CELLS AND ITS PRO ANGIOGENIC ROLE IN OVARIAN TUMORS%WIKIPATHWAYS_20260710%WP4397%HOMO SAPIENS MSMP expression regulation in cancer cells and its pro angiogenic role in ovarian tumors CTCF MSMP CCR2 T CELL RECEPTOR AND CO STIMULATORY SIGNALING%WIKIPATHWAYS_20260710%WP2583%HOMO SAPIENS T cell receptor and co stimulatory signaling NFKBIA PDCD1 CD8B CD8A FYN ZAP70 NFATC2 PRKCA LCK CTLA4 CSNK1A1 GSK3B PLCG1 DYRK2 PTPN6 GSK3A PTEN IL2 PPP3CA ITK NFKB1 CALM1 DYRK1A METABOLISM OF DICHLOROETHYLENE BY CYP450%WIKIPATHWAYS_20260710%WP3666%HOMO SAPIENS Metabolism of dichloroethylene by CYP450 CYP2E1 TAR SYNDROME%WIKIPATHWAYS_20260710%WP5362%HOMO SAPIENS TAR syndrome LAMTOR1 LCK DDIT4 HDAC2 SLC34A3 ANKRD35 EIF4A3 GPR89B SLK SUMO2 MAGOH NUDT17 HEL-S-76p SLC22A4 PEX11B STAT3 CLCN3 EGFR FARP2 HLA-A NHERF1 HLA-F UBE2I HLA-G PYM1 HLA-E PDZK1IP1 MITD1 FURIN CD160 HLA-C PEX19 IFNG HLA-B CXCR4 AKAP10 CCAR2 TNFRSF14 RBCK1 NFKB1 HAMP CD3D CFTR TXN SIRT1 FLT3 ZFHX3 ITGB1 POLR3GL POLR3C POLR3F BCL2L13 POLR3G LUPUS THERAPIES%WIKIPATHWAYS_20260710%WP5560%HOMO SAPIENS Lupus therapies IL6R C4A MS4A1 C1QB C1QA CD40LG C4B_2 CD40 C1QC IL25 IL12B TNLG7A IL23A IL17F IL17D IL17C IL17B CD80 IL17A IL12A HEL-S-62p CD19 IL6 IFNG CD22 EGFR TYROSINE KINASE INHIBITOR RESISTANCE%WIKIPATHWAYS_20260710%WP4806%HOMO SAPIENS EGFR tyrosine kinase inhibitor resistance VEGFA RPS6KB2 MAPK3 GRB2 RRAS2 PRKCB PRKCA MTOR RPS6KB1 RRAS EIF4E NRG1 STAT3 EGFR IGF1R BCL2L11 NRG2 PDGFRA MYC FOXO3A AXL JAK1 IL6 PDGFA IGF1 SOS2 BCL2 BAX FGFR3 BCL2L1 IL6R ERBB2 ARAF EGF CCND1 GSK3B AKT3 KDR PLCG1 BAD PTEN PIK3CD RPS6 PIK3R3 FGF2 HRAS PIK3R1 ERBB3 MAP2K1 NRAS PLCG2 MAP2K2 EIF4EBP1 PDPK1 FGFR2 SHC2 SOS1 RAF1 PIK3CA TGFA SHC3 NF1 SHC1 SRC PDGFD SHC4 PIK3R2 PDGFC HGF MAPK1 CARDIAC PROGENITOR DIFFERENTIATION%WIKIPATHWAYS_20260710%WP2406%HOMO SAPIENS Cardiac progenitor differentiation MYH6 BMP4 ZFP42 POU5F1 CXCR4 MEF2C SCN5A TBX20 IRX4 TBX5 NODAL INHBA GSK3B MYLK3 KDR MIXL1 FOXA2 WNT3A SOX2 SOX17 FGF2 INS NRG1 GATA4 SIRPA NKX2-5 BMP1 LIN28A MESP2 DKK1 MESP1 THY1 SOX1 NOTCH1 TNNI3 PDGFRA TGFB1 LIN28B NCAM1 ROR2 ISL1 TBXT IGF2 MAPK14 KIT MYL2 IGF1 NOG EIF5A REGULATION IN RESPONSE TO INHIBITION OF THE NUCLEAR EXPORT SYSTEM%WIKIPATHWAYS_20260710%WP3302%HOMO SAPIENS eIF5A regulation in response to inhibition of the nuclear export system IGF2BP1 EIF5A XPO4 NONALCOHOLIC FATTY LIVER DISEASE%WIKIPATHWAYS_20260710%WP4396%HOMO SAPIENS Nonalcoholic fatty liver disease NDUFA5 NDUFA13 NDUFA11 COX4I2 NDUFA12 NDUFA10 ATF4 COX6A2 NDUFC2 NDUFC1 SDHC SDHD COX7A2L NDUFS6 NDUFS5 COX7B NDUFS4 NDUFS1 COX6A1 NDUFB9 COX7C NDUFB8 NDUFB7 NDUFB6 NDUFB5 NDUFB4 NDUFB3 NDUFC2-KCTD14 COX8A COX6B2 COX7B2 NDUFB2 SDHA MLX COX8C NDUFB1 MLXIP COX7A2 UQCRHL COX6B1 NDUFV3 NDUFV2 NDUFB11 NR1C1 NDUFA7 NDUFA6 PKLR ZNF183 NDUFA3 NDUFA2 LEPR CYP2E1 ADIPOR1 NDUFAB1 TNF COX5A COX7A1 COX3 COX2 COX1 GSK3B PRKAA1 RAC1 PRKAA2 XBP1 PRKAG1 PIK3CD PIK3R3 EIF2S1 PRKAG2 INS ERN1 DDIT3 PIK3R1 PRKAG3 PRKAB2 PRKAB1 NR1H3 MLXIPL PIK3CA MAP3K11 GSK3A RELA COXFA4L2 VCAM1 CASP8 ADIPOR2 CASP3 CYCS MAPK8 BCL2L11 IL1A BAK1 MAP3K5 SDHB JUN IRS1 TRAF2 BBC3 CEBPA TNFRSF1A SOCS3 IL6 TNFSF6 BAX IL6R MAPK9 LEP ITCH CYB UQCRFS1 NDUFS8 UQCRC1 NDUFS3 AKT3 COXFA4 UQCRC2 UQCRB IL1B UQCR11 INSR UQCR10 UQCRH NFKB1 CYC1 CXCL8 NDUFA9 CCL2 UQCRQ IKBKB NR1H4 RXRA TGFB1 PIK3R2 NDUFB10 CDC42 JAK STAT SIGNALING IN THE REGULATION OF BETA CELLS%WIKIPATHWAYS_20260710%WP5358%HOMO SAPIENS JAK STAT signaling in the regulation of beta cells IL6R MLST8 PRLR AKT1S1 EPOR RPTOR STAT1 MTOR SOCS2 AKT3 PRL CISH GH1 HRAS GHR NRAS STAT3 CDK4 IFNGR1 IFNGR2 FOXM1 CCND3 CCND2 SOCS3 SOCS1 IL6 EPO IFNG STAT5B KISSPEPTIN KISSPEPTIN RECEPTOR SYSTEM IN THE OVARY%WIKIPATHWAYS_20260710%WP4871%HOMO SAPIENS Kisspeptin kisspeptin receptor system in the ovary MAPK3 DKFZp686L0365 PRKCB KISS1 PRKCA PLCB3 PLCB4 CYP11A1 PLCB1 PIK3CD PLCB2 PRKCH NFKB1 HRAS BMP15 NRAS AMH MAP2K1 MAP2K2 FSHR STAR RAF1 PIK3CA PRKCE KISS1R PRKCQ HSD3B1 MAPK1 MMP9 GENES ASSOCIATED WITH THE DEVELOPMENT OF RHEUMATOID ARTHRITIS%WIKIPATHWAYS_20260710%WP5033%HOMO SAPIENS Genes associated with the development of rheumatoid arthritis MHC2TA STAT4 IL6ST HLA-DRB1 BLK CTLA4 CD40 FCRL3 PTPN22 IL2RA PADI4 TRAF1 CCR6 CD244 PHF19 ITGAV SLC22A4 SARS CORONAVIRUS AND INNATE IMMUNITY%WIKIPATHWAYS_20260710%WP4912%HOMO SAPIENS SARS coronavirus and innate immunity TYK2 TBK1 IFNB1 IRF3 STAT1 IRF9 IFNA5 IFNA4 IFNA7 TICAM1 IFNA6 IFNA1 IFNA2 IKBKE TRAF3 IFNA8 IFNA21 IFNAR2 IFNA13 IFNA14 ACE2 IFNA16 STAT2 IFNA17 TLR3 IFNA10 IFNAR1 IFIH1 MAVS JAK1 RIGI INDUCTION OF AUTOPHAGY AND TOLL LIKE RECEPTOR SIGNALING BY GRAPHENE OXIDE %WIKIPATHWAYS_20260710%WP5336%HOMO SAPIENS Induction of autophagy and toll like receptor signaling by graphene oxide MAP1LC3A IFNB1 TLR9 NFKB1 IRF3 TNF IFNG TRAF6 MYD88 TLR4 ESTROGEN METABOLISM%WIKIPATHWAYS_20260710%WP697%HOMO SAPIENS Estrogen metabolism GSTM1 UGT2B7 CYP3A4 SULT1E1 SULT1A1 UGT1A1 UGT1A3 CYP1A2 UGT1A9 CYP1A1 NQO1 STS ARSL CYP1B1 IMATINIB AND CHRONIC MYELOID LEUKEMIA%WIKIPATHWAYS_20260710%WP3640%HOMO SAPIENS Imatinib and chronic myeloid leukemia GAB2 LYL1 ABCB1 CSF1R PDGFRA CDKN1B SKP2 GADD45A BCR KIT FLT1 ABCG2 MYC NOP2 FOXO3A PIM1 PIM2 IL7 SIGNALING%WIKIPATHWAYS_20260710%WP205%HOMO SAPIENS IL7 signaling MAP2K2 MAPK3 FYN PTK2B STAT1 GSK3B PIK3R2 BAD IL2RG IL7 IL7R JAK1 JAK3 PIK3R1 STAT5B MAP2K1 STAT3 MAPK1 PARKIN UBIQUITIN PROTEASOMAL SYSTEM PATHWAY%WIKIPATHWAYS_20260710%WP2359%HOMO SAPIENS Parkin ubiquitin proteasomal system pathway UBE2L6 TUBA3E TUBA1C UBE2G1 TUBB6 UBE2G2 TUBA1B SEPT5 TUBA1A PSMD10 TUBB1 PSMD7 PSMD5 TUBB PSMC6 TUBB4B CASP8 TUBB4A PSMC4 TUBA4A TUBB2A GPR37 CASK PSMD12 TUBA2 PSMD13 UBE2J2 TUBA8 PSMD11 FBXW7 HEL-S-72p RNF19A PSMD9 TUBA4B PSMD6 HSPA14 PSMD4 PSMD3 PSMD1 PSMC1 UBE2J1 SNCA PSMD2 HEL-S-89n CCNE1 PARK2 UBE2L3 HSPA2 SIAH2 TUBAL3 SIAH1 HEL-S-91n HSPA1A HSPA4 SNCAIP TUBB8 STUB1 INSULIN SIGNALING%WIKIPATHWAYS_20260710%WP481%HOMO SAPIENS Insulin signaling MAPK10 SNAP25 GRB2 FOXO1 PRKCA EIF4E RPS6KA5 IGF1R LIPE MAP3K14 GRB14 GYG1 PRKCQ HEL-S-61 STXBP1 INPP4A STXBP3 STXBP4 RRAD EHD1 EHD2 SNX26 PPP1R3A STX4A PFKL RAB4A SLC2A4 PFKM VAMP2 GSK3B PRKAA1 RAC1 PRKAA2 PTEN XBP1 PIK3CD PIK3R3 TSC1 PIK3R1 IRS4 EIF4EBP1 CBLC RPS6KA4 RPS6KA6 RPS6KA2 MAP3K8 MAP3K6 SHC2 RAF1 MAP3K10 PIK3CA RHEB MAP3K13 MAP3K11 MAP3K12 HEL-S-31 GYS1 FLOT1 FLOT2 MAP4K1 GSK3A MAP4K2 MINK1 GYS2 MAP4K3 MAP3K2 SGK1 PTPN1 SGK2 MAPK1 HEL-S-42 RPS6KB2 MAPK3 PRKCB ARF6 MTOR RPS6KB1 ENPP1 EGR1 GRB10 SNAP23 ARF1 PTPRF MAPK8 SH2B2 MAP3K5 MAP2K6 MAP2K3 MAP2K4 JUN IRS1 PIK3C2G FOS MAPK14 MAPK12 CBL MAPK13 SOCS3 FOXO3A SOCS1 MAPK11 MAP3K7 INPPL1 PTPN11 SOS2 PIK3R4 CAP1 MAPK9 RPS6KA1 KIF3A MYO1C TSC2 MAP3K1 INSR PRKCI PRKCH HRAS PRKCZ MAP2K1 MAP2K2 PDPK1 IKBKB TBC1D4 RAPGEF1 SOS1 CRK SHC3 SHC1 PIK3R2 MAPK7 MAPK6 TRIB3 MAPK4 MAP2K5 CEREBRAL ORGANIC ACIDURIAS INCLUDING DISEASES%WIKIPATHWAYS_20260710%WP4519%HOMO SAPIENS Cerebral organic acidurias including diseases GCDH ADHFE1 D2HGDH L2HGDH HEL-S-5 ALDH7A1 MDH2 ACQUIRED PARTIAL LIPODYSTROPHY BARRAQUER SIMONS SYNDROME%WIKIPATHWAYS_20260710%WP5104%HOMO SAPIENS Acquired partial lipodystrophy Barraquer Simons syndrome CFB HEL-S-62p LMNB2 CFD FNTA LMNA ICMT RCE1 NEPHROGENESIS%WIKIPATHWAYS_20260710%WP5052%HOMO SAPIENS Nephrogenesis PAX2 GREB1L TCF21 ALDH1A2 WNT4 RSPO3 RSPO1 MEIS1 FOXD1 OSR1 FGF20 WNT3A NOTCH2 WNT9B BMP7 FGF8 SIX2 PDGF PATHWAY%WIKIPATHWAYS_20260710%WP2526%HOMO SAPIENS PDGF pathway NFKBIA MAPK3 GRB2 STAT1 COX2 MAP3K1 PLCG1 RAC1 ARHA NFKB1 HRAS PIK3R1 MAP2K1 STAT3 MAPK8 CHUK VAV2 SOS1 RAF1 MAP2K4 TIAM1 JUN SHC1 SRC VAV1 FOS WASL PAK1 JAK1 PDGFA CDC42 MAPK1 PTPN11 ENDOCHONDRAL OSSIFICATION%WIKIPATHWAYS_20260710%WP474%HOMO SAPIENS Endochondral ossification VEGFA ACAN COL10A1 PTH1R DDR2 ALPL ENPP1 CAB39 CALM1 FGF18 IGF1R PLAT RUNX2 SCIN MGP SOX6 PTCH1 FGFR1 GLI3 STAT5B IGF1 BMP6 opn RUNX3 FGFR3 PTH MEF2C PTHLH BMPR1A CDKN1C ADAMTS4 ADAMTS5 NKX3-2 KIF3A CST5 STAT1 CHST11 BMP7 FGF2 GH1 GHR HMGCS1 SOX9 SOX5 TGFB1 THRA IGF2 TIMP3 FRZB COL2A1 MMP9 SENESCENCE ASSOCIATED SECRETORY PHENOTYPE SASP %WIKIPATHWAYS_20260710%WP3391%HOMO SAPIENS Senescence associated secretory phenotype SASP H2AC6 H2BC17 H2BC12 CDK2 MAPK3 H2BC13 UBE2D1 H2AJ CDC23 H2BC14 H2BC15 CDC27 H2BC11 HIST1H2BE ANAPC7 ANAPC5 RPS27A ANAPC1 ANAPC2 H3C15 ANAPC10 ANAPC11 H2BC9 CEBPB H2AZ1 STAT3 CDKN1A H2AZ2 H4C9 H2BC8 IL1A H3F3B HIST1H4L H2BC3 H2BC1 IGFBP7 H2AC20 CDKN1B JUN CDKN2A FOS FZR1 CCNA2 IL6 CDKN2D UBE2C RPS6KA1 CDC26 VENTX ANAPC15 C10orf104 EHMT1 UBE2S NFKB1 CXCL8 CDKN2B CDKN2C CDK6 CDK4 RPS6KA2 UBB UBC H2AX UBE2E1 H2AC19 H2AB1 MAPK7 RELA H2AC14 H2BC26 H2BC12L H2BC21 HIST1H2AB H3C8 MAPK1 INTRAFLAGELLAR TRANSPORT PROTEINS BINDING TO DYNEIN%WIKIPATHWAYS_20260710%WP4532%HOMO SAPIENS Intraflagellar transport proteins binding to dynein IFT140 DYNLT3 IFT25 DYNC2I2 DYNLL2 IFT43 DYNC1H1 DYNC1I1 DYNC1LI2 IFT80 IFT46 DYNC1LI1 IFT81 DYNC2H1 IFT22 DNCL1 DYNLT2B DYNC2LI1 WDR35 DYNLT1 IFT27 DYNLRB2 IL11 SIGNALING%WIKIPATHWAYS_20260710%WP2332%HOMO SAPIENS IL11 signaling TYK2 BCL2 FES BGLAP MAPK3 GRB2 IL6ST FYN IL11RA IBSP RPS6KA1 PTPA BIRC5 STAT1 YES1 RPS6KB1 RPS6 HRAS PIK3R1 IL11 MAP2K1 STAT3 MAP2K2 ATF1 PDPK1 CREB1 CHUK ITGA2 PIAS1 IKBKB RUNX2 RAF1 TGFB1 SRC PIK3R2 RELA SOCS3 JAK1 MAPK1 PTPN11 GUT LIVER INDOLE METABOLISM %WIKIPATHWAYS_20260710%WP3627%HOMO SAPIENS Gut liver indole metabolism CYP2E1 KIT RECEPTOR SIGNALING%WIKIPATHWAYS_20260710%WP304%HOMO SAPIENS Kit receptor signaling GAB2 MAPK3 GRB2 FYN PRKCB RPS6KA1 PRKCA INPP5D STAT1 RPS6KB1 EP300 PLCG1 SOCS6 BAD MATK RPS6 BTK HRAS PIK3R1 GRB10 MAP2K1 STAT3 KITLG MAP2K2 DOK1 CRKL MAPK8 TEC SH2B2 GRB7 SOS1 RAF1 CRK SHC1 SRC VAV1 PIK3R2 MAPK14 PTPN6 KIT CBL LYN SOCS1 FOXO3A STAT5B MAPK1 PTPN11 OPIOID RECEPTOR PATHWAYS%WIKIPATHWAYS_20260710%WP5093%HOMO SAPIENS Opioid receptor pathways HMOX1 ALDH9A1 RPLP2 CACNA1B TNF TUBB JUP RAC1 HDAC1 NEU2 GATA4 TLR4 NOS2 BDNF DKFZp762B153 ARC ADCY1 ADCY8 PRKCE SQSTM1 OPRM1 RELA HEL-S-72p MBP RGS4 OMEGA 6 FATTY ACIDS IN SENESCENCE%WIKIPATHWAYS_20260710%WP5424%HOMO SAPIENS Omega 6 fatty acids in senescence ALOX15 PTGIS HPGD ELOVL5 ELOVL2 ALOX12 LTC4S PTGS2 ALOX15B PTGS1 FADS2 FADS1 PTGES HEL-S-298 HEL-S-22 GPX1 ALOX5AP PRXL2B DPEP2 RB1 SIRT1 HEL-S-53e DECR1 CDKN1A EPHX2 SLCO2A1 CYP4F8 NAT2 AKR1B1 PTGES3 MAPK11 ALOXE3 ALOX5 GLUCOCORTICOID BIOSYNTHESIS%WIKIPATHWAYS_20260710%WP5280%HOMO SAPIENS Glucocorticoid biosynthesis AKR1C1 AKR1D1 AKR1C2 AKR1C4 CYP3A4 SRD5A2 HSD11B1 HSD11B2 CYP21A2 CYP11B2 NEURAL CREST CELL MIGRATION IN CANCER%WIKIPATHWAYS_20260710%WP4565%HOMO SAPIENS Neural crest cell migration in cancer NGFR SORT1 PIK3R4 PIK3R5 F2RL2 TRIO AKT3 RAC1 ARHA PIK3CD PIK3R3 EPHB2 EPHB4 STAT3 TWIST1 EPHB6 ARF1 NTRK2 EPHB1 EPHB3 BDNF KIDINS220 PIK3CA TIAM1 JUN MMP2 FOS CDH11 PAK6 PAK1 PAK4 MMP9 CLEAR CELL RENAL CELL CARCINOMA PATHWAYS%WIKIPATHWAYS_20260710%WP4018%HOMO SAPIENS Clear cell renal cell carcinoma pathways VEGFA KSR1 MLST8 HEL-S-32 AKT1S1 RAPGEF5 HEL-S-30 MTOR ENO1 ENO2 ENO3 FASN HK3 BHLHE41 CAMK1 PHGDH GRB10 HEL-S-162eP STAT3 PSPH EGFR CREBBP HEL-S-68p SSPN ALDOB ME1 PDGFRA VHL HEL-S-87p SHMT1 HEL-S-51e SETD2 PKLR HEL-S-133P HEL-S-281 HEL-S-49 PFKL PSAT1 HK2 PFKM RPTOR TSC2 PFKP ACACB KDR CEP290 EP300 KDM5C PTEN ACLY EFCAB3 BAP1 PLOD2 PGM2 PBRM1 TSC1 SDSL PGBD5 LDHD DEPTOR KCNJ2 ENPP3 RHEB SQSTM1 HIF1A FLT1 ACACA MAP2K5 2Q11 2 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260710%WP5221%HOMO SAPIENS 2q11 2 copy number variation syndrome ERBB2 MAPK3 CIAO2A ANKRD23 ARHA ANKRD39 PARL CIAO1 ITPRIPL1 TMEM127 CIAO2B CNNM3 CNNM4 FER1L5 STARD7 SEMA4C ARID5A ASTL NEURL3 COX11 KANSL3 PLXNB2 SNRNP200 MMS19 ZP2 ADRA2B COL2A1 DUSP2 MAPK1 ADIPOGENESIS%WIKIPATHWAYS_20260710%WP236%HOMO SAPIENS Adipogenesis PTGIS MEF2D NDN FOXO1 CELF1 FZD1 SFRP4 GATA4 CEBPD STAT3 TWIST1 NR2F1 BMP1 LIPE NR1C2 GDF10 RXRG PCK1 NR1C1 WWTR1 MEF2C EGR2 PRLR SLC2A4 RARA TNF MBNL1 NCOR2 STAT1 RORA LIF NCOR1 HNF1A RETN GH1 CISD1 INS DDIT3 IRS4 CREB1 PNPLA3 LPIN1 NR1H3 CYP26A1 GTF3A SCD ADFP ID3 SPOCK1 KLF7 KLF6 HIF1A PLIN1 LPL CYP26B1 OSM PCK2 LMNA ASIP HMGA1 BSCL2 LPIN3 RB1 CEBPB CDKN1A GADD45B STAT2 GATA3 RBL1 IRS1 GATA2 CEBPA SOCS3 LPIN2 SOCS1 IL6 KLF15 WNT5B E2F4 STAT5B IGF1 BMP4 BMP3 NCOA1 BMP2 IL6ST DVL1 LEP WNT1 FOXC2 PPARGC1A WNT10B NR3C1 KLF5 RBL2 MIXL1 GADD45A NAMPT AHR MEF2B UCP1 PPARG CFD SP1 RXRA TGFB1 ZMPSTE24 CNTFR FRZB TRIB3 CALCIUM MEDIATED T CELL APOPTOSIS INVOLVED IN INCLUSION BODY MYOSITIS%WIKIPATHWAYS_20260710%WP5142%HOMO SAPIENS Calcium mediated T cell apoptosis involved in inclusion body myositis MEF2D CD8B CD8A ZAP70 NFATC2 LCK CABIN1 HDAC2 EP300 PLCG1 ITPRIP HDAC1 ATP2A1 PPP3CA CALM1 PPP3CC GLYCOGEN SYNTHESIS AND DEGRADATION%WIKIPATHWAYS_20260710%WP500%HOMO SAPIENS Glycogen synthesis and degradation HK2 PTPA GSK3B PPP2R1A PYGL HK3 PPP2R5D CALM1 PPP2R2A PPP2R5B PPP2R5A PPP2CA PPP2R1B PHKG2 GYS1 GYG1 PYGB GSK3A PYGM PPP2R5E AGL PHKB PHKA2 PPP2R3B PHKA1 GYS2 PPP2R3A PPP2R2C PPP2R5C PPP2R2B GLUCURONIDATION%WIKIPATHWAYS_20260710%WP698%HOMO SAPIENS Glucuronidation UGT2A2 UGDH UGT2A1 UGT2B7 UGT2B28 UGT1A8 PGM3 UGT1A10 UGT1A1 UGT1A5 UGT1A4 UGT1A3 UGT1A9 UGT1A7 PGM2 UGT2B10 PGM5 UGT2B11 UGT2B15 UGT2B4 UGT2B17 NOD LIKE RECEPTOR NLR SIGNALING%WIKIPATHWAYS_20260710%WP288%HOMO SAPIENS Nod like receptor NLR signaling CD40 MAPK8 CHUK IKBKB RELA ERBIN IKBKG MAP3K7 EPHB2 DNA IR DAMAGE AND CELLULAR RESPONSE VIA ATR%WIKIPATHWAYS_20260710%WP4016%HOMO SAPIENS DNA IR damage and cellular response via ATR RECQL4 CLSPN CLK2 CDK2 UBE2D3 RFWD3 CHEK2 CHEK1 MSH2 MDC1 CEP164 PRKDC TP53BP1 PML RAD17 MCPH1 XRCC5 BRCA1 CDC2 PLK1 POLN UIMC1 ATR RMI1 TOP3A XPA MCM2 CDC45 WRN PPM1D RBBP8 ABRAXAS1 BRCC3 RAD52 RAD50 TDP1 RAD51 FEN1 RPA1 MRE11A NBN BRCA2 SHFM1 BARD1 SMC1A BRIP1 BCL6 HERC2 FANCD2 MDM2 ATM HUS1 PCNA RAD1 TOPBP1 FANCA SMARCC2 ATRIP SP1 USP1 PALB2 IKBKG FOXM1 H2AX SMARCAL1 RAD9A RNF8 DCLRE1A TRIM28 RECQL EEF1E1 THIAMINE METABOLIC PATHWAYS%WIKIPATHWAYS_20260710%WP4297%HOMO SAPIENS Thiamine metabolic pathways SLC19A2 BCKDK SLC19A3 DKFZp667O1614 OGDH HEL107 PDHA1 MACROPHAGE STIMULATING PROTEIN MSP SIGNALING%WIKIPATHWAYS_20260710%WP5353%HOMO SAPIENS Macrophage stimulating protein MSP signaling VEGFA CXCL2 CPT1A SLPI BGLAP MAPK3 GRB2 SNAI2 PRKCB IBSP FZD1 MTOR RPS6KB1 RPS6KA5 EGR1 DKFZp781O1323 MAPK8 IGF1R CSF2 PDGFRA JUN TJP1 FOS MAPK14 FGFR1 SIX1 SOCS3 SMAD1 CSF3 SOCS1 SMAD9 IL6 HEL-S-133P MAPK9 HEL-S-102 ZEB2 IFNB1 SP7 TNF RPS6KA1 PPARGC1A HK2 SMAD2 WNT10B GSK3B KDR SMAD6 PLCG1 PRKAA2 PTEN IL1B RPS6 NFKB1 CXCL8 DUSP4 COL4A1 CXCL1 PIK3R1 CXCL5 MAP2K1 CCL2 MAP2K2 CRKL PDPK1 PCNA RPS6KA4 MST1R CLDN5 NR0B2 IL10 RAF1 TGFB1 SHC1 SRC ITGB1 HEL113 ACTA2 CDH2 RELA FLT1 ACACA KLK15 CLDN1 MMP9 MAPK1 INTERACTOME OF POLYCOMB REPRESSIVE COMPLEX 2 PRC2 %WIKIPATHWAYS_20260710%WP2916%HOMO SAPIENS Interactome of polycomb repressive complex 2 PRC2 BCLAF1 MORC3 SUZ12 ELL AEBP2 THRAP3 STK38 TRIM35 RBBP7 EED SETX EZH1 EZH2 RBBP4 JARID2 FOLLICLE STIMULATING HORMONE FSH SIGNALING%WIKIPATHWAYS_20260710%WP2035%HOMO SAPIENS Follicle stimulating hormone FSH signaling FSHR RPS6KB2 EIF4EBP1 CREB1 MAPK3 CGA FOXO1 FSHB APPL1 RAF1 PRKCA RHEB TSC2 MTOR H3-4 SRC RPS6KB1 MAPK14 RPS6 SGK1 MAPK1 FABP4 IN OVARIAN CANCER%WIKIPATHWAYS_20260710%WP4400%HOMO SAPIENS FABP4 in ovarian cancer HEL-S-104 PAFAH1B1 COPY NUMBER VARIATION%WIKIPATHWAYS_20260710%WP5409%HOMO SAPIENS PAFAH1B1 copy number variation HEL-S-303 RELN VLDLR PAFAH1B1 NDEL1 TUBA1A DYNC1H1 NUDC CANONICAL AND NON CANONICAL NOTCH SIGNALING%WIKIPATHWAYS_20260710%WP3845%HOMO SAPIENS Canonical and non canonical Notch signaling LEF1 JAG2 CHUK MAML3 PSEN2 DLL3 PSEN1 MAML2 DLK2 MFAP2 NOTCH1 DNER RBPJ MFAP1 ADAM10 NOTCH2 MAML1 RRAS NOTCH3 NOTCH4 DLL4 HES1 CANCER IMMUNOTHERAPY BY CTLA4 BLOCKADE%WIKIPATHWAYS_20260710%WP4582%HOMO SAPIENS Cancer immunotherapy by CTLA4 blockade CTLA4 PIK3R2 PTPN6 PIK3CD HLA-DRB1 PPP2CA PIK3R3 PIK3CA PIK3R1 CD80 PTPN11 IL17 SIGNALING%WIKIPATHWAYS_20260710%WP2112%HOMO SAPIENS IL17 signaling MAPK3 GSK3B TRAF3 TRAF3IP2 NFKB1 IL25 CEBPB CEBPD STAT3 IL17RC IL17RB IL17RA IKBKB MAP3K14 SP1 IKBKG IL17F IL17D PIK3CA IL17C IL17B IL17A NFKBIB RELA MAP3K7 JAK1 TRAF6 MAPK1 ATM SIGNALING%WIKIPATHWAYS_20260710%WP2516%HOMO SAPIENS ATM signaling MAPK9 CDK2 PIDD1 CHEK2 RAD50 CHEK1 RAD51 MRE11A NBN MDC1 GADD45A RIPK1 DKFZp781B1423 TP53BP1 SMC1A CASP2 ATF2 CDKN1A BRCA1 MDM2 TLK1 ATM CDC2 CREB1 TP73 CCNE1 IKBKG CCNB1 JUN H2AX CRADD RAD9A HEPATITIS B INFECTION%WIKIPATHWAYS_20260710%WP4666%HOMO SAPIENS Hepatitis B infection MAPK10 GRB2 YWHAQ IRF3 PRKCA ATF4 BIRC5 CASP12 IKBKE TLR4 STAT3 NFATC4 CASP10 PTK2B JAK1 TGFBR1 TGFBR2 EGR2 TNF SMAD2 STAT1 CREB3 CREB3L3 CREB3L4 EP300 CREB3L2 CREB5 PIK3CD PIK3R3 PIK3R1 NRAS CREB1 VDAC3 MAP3K7IP1 RAF1 PIK3CA RELA MMP9 MAPK1 MAPK3 TBK1 PRKCB HSPG2 NFATC2 CASP9 CASP8 IFNA5 CASP3 CYCS IFNA4 IFNA7 FADD IFNA6 IFNA1 IFNA2 IFNA8 IFNA21 NFATC3 ATF2 IFNA13 CDKN1A IFNA14 CREBBP MAPK8 IFNA16 STAT2 IFNA17 IRF7 ATF6B MAP2K6 HEL-S-1 MAP2K3 IFNA10 MAP2K4 IFNAR1 JUN IFIH1 FOS MAPK14 MAPK12 MAPK13 MYC MAPK11 MAP3K7 IL6 TNFSF6 JAK3 NFATC1 DDB2 STAT5B TRAF6 BCL2 TYK2 DDB1 SOS2 BAX DDX3X STAT4 MAPK9 IFNB1 ARAF TICAM2 SMAD4 MAP3K1 AKT3 APAF1 TICAM1 BAD TRAF3 NFKB1 CXCL8 HRAS MAP2K1 MAP2K2 PCNA CHUK IRAK4 IKBKB TIRAP IKBKG SOS1 TLR3 IRAK1 TGFB1 SRC PIK3R2 HEL-S-93 MAVS MYD88 RIGI 15Q11 2 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260710%WP4940%HOMO SAPIENS 15q11 2 copy number variation syndrome TUBGCP4 CYFIP1 NIPA1 FMR1 NIPA2 TUBGCP5 TUBGCP6 MICRORNA FOR TARGETING CANCER GROWTH AND VASCULARIZATION IN GLIOBLASTOMA%WIKIPATHWAYS_20260710%WP3593%HOMO SAPIENS MicroRNA for targeting cancer growth and vascularization in glioblastoma VEGFA VEGFB HIF1AN HIF1A VEGFC HES1 WNT SIGNALING%WIKIPATHWAYS_20260710%WP428%HOMO SAPIENS Wnt signaling CSNK2B LRP6 PRKCA PORCN FZD1 CSNK1A1 FZD7 FZD8 CER1 PPP3CA ARHA CTNNBIP1 SFRP4 KREMEN1 PPP3R1 SENP2 SFRP5 PPP3R2 CAMK2D CXXC4 NKD1 NKD2 NOTUM FZD2 NFATC4 SFRP1 WIF1 DKK2 CCND1 GSK3B FZD9 RAC1 DKK4 FZD10 CHD8 PRKCB NFATC2 DAAM2 PRICKLE2 GPC4 PLCB3 PLCB4 PLCB1 SOX17 PLCB2 CTBP2 NFATC3 CAMK2A MAPK8 CAMK2G SOST DKK1 FZD5 WNT2B JUN LRP5 FRAT1 CCND3 CCND2 MYC MAP3K7 WNT5B NFATC1 AXIN1 WNT16 NLK LEF1 MAPK9 DVL1 DVL2 DAAM1 DVL3 FRAT2 WNT1 WNT3 WNT4 WNT10B TCF7L2 WNT10A TCF7L1 WNT3A WNT7B WNT7A FOSL1 APC PPP3CC CTBP1 hCG_2014051 CSNK2A1 RYK CSNK2A3 INVS CSNK2A2 ROR1 ROR2 ROCK2 VANGL1 FZD3 GLYCOSYLATION AND RELATED CONGENITAL DEFECTS%WIKIPATHWAYS_20260710%WP4521%HOMO SAPIENS Glycosylation and related congenital defects ALG2 ALG14 MAGT1 ALG13 ALG3 ALG12 ALG1 ALG11 DPM1 DPM2 DPM3 GCS1 DPAGT1 B4GALT1 TUSC3 GMPPB ALG8 MGAT2 MPDU1 ALG9 SRD5A3 DOLK ALG6 ARYLAMINE METABOLISM%WIKIPATHWAYS_20260710%WP694%HOMO SAPIENS Arylamine metabolism NAT2 UGT1A4 CYP1A2 UGT1A9 SULT1A2 SULT1A1 4 HYDROXYTAMOXIFEN DEXAMETHASONE AND RETINOIC ACIDS REGULATION OF P27 EXPRESSION%WIKIPATHWAYS_20260710%WP3879%HOMO SAPIENS 4 hydroxytamoxifen dexamethasone and retinoic acids regulation of p27 expression MAP2K2 EIF4EBP1 HEL164 MAPK3 MAP3K5 RAF1 MAP2K6 MAP2K3 PIK3CA MAP3K11 TSC2 MTOR PIK3R2 PRKAA1 PIK3CD PIK3R3 EIF4E TSC1 PIK3R1 MAP2K1 MAPK1 2Q37 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260710%WP5224%HOMO SAPIENS 2q37 copy number variation syndrome NFKBIA CAPN10 HES6 NDUFA10 SEPTIN4 PRL NEU4 PER2 FARP2 UGT1A10 PDX1 ASCL1 EEF1A1 GABARAPL2 GABARAPL1 GABARAP D2HGDH IL13RA1 MEF2C IRF8 CXCR4 TNF SEPTIN2 BOK DISC1 MAP1LC3A RAC1 RPS6 RRAGA RRAGB CALCRL RRAGD RAMP1 MAP1LC3C DKFZp762B153 MLPH RAB27A GYS1 DTYMK PPP1R7 ACKR3 PDCD1 TRAF3IP1 GAL3ST2 ABCA1 UGT1A8 MYOG TWIST2 UGT1A1 MYOD1 MROH2A DGKD HJURP CXCL11 ERFE MAP4 KLHL30 THAP4 AGAP1 OR6B3 GPC1 TRPM8 OR6B2 UBE2F MTERF4 COPS9 CALM1 SNED1 RTP5 RNPEPL1 ING5 SEPT6 KIF1A EGFR ARF1 ILKAP AQP12B AQP12A DUSP28 ANO7 OTOS ARL4C USP40 ARF5 CALCA ASB18 CENPA CYTH2 SPP2 JUN PRLH ITPK1 SH3BP4 UGT1A4 ANKMY1 UGT1A3 CYTH1 UGT1A9 RAB17 ASB1 UGT1A7 AGXT PDGFA COPS8 NEDD8 ITGB3 IL1B TRAF3 HAMP HEL-S-28 CXCL12 GBX2 HES1 FOLATE METABOLISM%WIKIPATHWAYS_20260710%WP176%HOMO SAPIENS Folate metabolism HEL-S-44 APOB ABCA1 FGA SLC19A1 GPX2 GPX4 FLAD1 GPX3 CRP CSF1 GPX1 HEL-S-78p SAA4 PLAT MPO HBA2 F2 HBB IZUMO1R SHMT1 FOLR3 HEL-S-51e IL2 FOLR2 CBS IL6 IFNG FOLR1 TNF SLC46A1 CTH SAA1 SAA2 IL1B INSR NFKB1 INS NFKB2 SCARB1 F7 CCL2 PLG LDLR IL4 MTRR MTR MTHFS MAT1A RELA DHFR GPX6 MTHFD1 MTHFD2 ALB PURINERGIC SIGNALING%WIKIPATHWAYS_20260710%WP4900%HOMO SAPIENS Purinergic signaling P2RX1 P2RY4 P2RY2 GNAI3 P2RY1 GNAZ GNAI1 ADORA2A GNAO1 PANX1 GNA11 P2RX6 GNAS LPAR4 P2RY13 P2RY10 P2RY11 P2RY14 P2RY8 GNAT2 ADORA2B GNAT3 GNAT1 P2RX7 P2RX5 P2RX4 P2RX3 P2RY6 P2RX2 PANCREATIC CANCER SUBTYPES%WIKIPATHWAYS_20260710%WP5390%HOMO SAPIENS Pancreatic cancer subtypes SPRR3 ST6GALNAC1 HEL-S-116 HEL136 KRT20 CST6 LGALS4 VSIG2 AGR3 FAM3D KRT6C SERPINB3 BTNL8 S100A2 GPR87 KRT7 ANXA10 AREG LEMD1 DHRS9 CEACAM6 SCCA2 LY6D KRT6A TFF3 TFF1 VGLL1 CLRN3 SPRR1B SCEL REG4 TFF2 TNS4 CYP3A7 FGFBP1 PLA2G10 FAM83A CDH17 TSPAN8 LYZ BUTYRATE INDUCED HISTONE ACETYLATION%WIKIPATHWAYS_20260710%WP2366%HOMO SAPIENS Butyrate induced histone acetylation ACLY TESSADORI BICKNELL VAN HAAFTEN SYNDROME VARIANTS NUCLEOSOME ASSEMBLY%WIKIPATHWAYS_20260710%WP5573%HOMO SAPIENS Tessadori Bicknell van Haaften syndrome variants nucleosome assembly CHAF1B CHAF1A H4C9 SMIM40 H2BC12 HIST1H4L RBBP4 HIRA ARYL HYDROCARBON RECEPTOR RESPONSE TO MAIN MEDIATORS PAH AND TCDD%WIKIPATHWAYS_20260710%WP2586%HOMO SAPIENS Aryl hydrocarbon receptor response to main mediators PAH and TCDD VEGFA CDK2 PTGS2 TNF NCOR2 PLAGL1 CD36 EP300 NQO1 AHR CCL1 NFKB1 HRAS GCLC NFE2L2 RB1 NRAS MAP2K1 CDKN1A EGFR FGF21 CDC37 RAF1 CDKN1B NF1 SRC CYP1A2 CYP1A1 AHRR KLF6 RELA RET LPL MYC CYP1B1 AIP MAPK1 THYROID STIMULATING HORMONE TSH SIGNALING%WIKIPATHWAYS_20260710%WP2032%HOMO SAPIENS Thyroid stimulating hormone TSH signaling CDK2 GNAI3 RAP1GAP MAPK3 CGA APEX1 RPS6KA1 GNAI1 PDE4D STAT1 MTOR MYL12B RBL2 RPS6KB1 PLCB1 RPS6 KCNIP3 HRAS PIK3R1 RB1 MAP2K1 STAT3 PDPK1 CREB1 GNAO1 CDK4 IGF1R CCNE1 GNB1 GNAS ADCY3 MAP2K6 RAF1 MAP2K3 PIK3CA CDKN1B SCRIB GNG2 TSHB SRC PIK3R2 GNA13 RAP1A MAPK14 CCND3 JAK1 TSHR MAPK1 EXTRACELLULAR VESICLES IN THE CROSSTALK OF CARDIAC CELLS%WIKIPATHWAYS_20260710%WP4300%HOMO SAPIENS Extracellular vesicles in the crosstalk of cardiac cells HEL-S-44 opn EGFR HEL-S-102 CD63 ETS2 EGF BIRC5 KDR PTEN IL6 GATA4 IGF1 CD81 STAT3 MMP9 TLR4 NETRIN UNC5B SIGNALING%WIKIPATHWAYS_20260710%WP4747%HOMO SAPIENS Netrin UNC5B signaling COL1A1 MAPK3 DCSTAMP VCAM1 FYN ITGB4 NTN1 TNF PRKCA INPP5D SELE PTPA MYF5 CASP3 KDR RAC1 ARHA ALPL RLF NTN3 PLEKHH1 CCL2 MAP2K1 UNC5B AGAP2 MAP2K2 CIP2A ROBO4 ARHGEF12 IL1A PPP2R1B IL10 RAF1 PIK3CA PTK2B JUN SRC MAPK14 CTGF YAP1 RGMA MAPK1 PTPN11 PPAR SIGNALING%WIKIPATHWAYS_20260710%WP3942%HOMO SAPIENS PPAR signaling PLTP CYP27A1 PCK2 SLC27A5 ACOX1 CPT2 ACSL1 CPT1C OLR1 HEL-S-104 FADS2 EHHADH FABP1 DBI CD36 SLC27A4 ANGPTL4 UCP1 PPARG PDPK1 CYP4A11 HEL-S-28 UBC RXRA RXRB NR1H3 AQP7 CYP7A1 NR1C2 ME1 APOC3 RXRG SCD APOA2 PLIN1 LPL NR1C1 PCK1 APOA5 CYP8B1 SLC27A1 CARDIAC HYPERTROPHIC RESPONSE%WIKIPATHWAYS_20260710%WP2795%HOMO SAPIENS Cardiac hypertrophic response CDK7 TGFBR1 MAPK3 TNF NFATC2 PRKCA EGF MTOR MAP3K1 GSK3B RAC1 PPP3CA NPPA IKBKE FGF2 NFKB1 CAMK2D NRG1 PRKD1 CALM1 HDAC7 MAP2K1 MAP2K2 GUCA1A PLA2G2A MAPK8 PDPK1 CHUK CDK9 IKBKB MAP3K14 FGFR2 IKBKG MAP2K6 RAF1 MAP2K3 PRKG1 MAP2K4 TGFB1 MAPK14 MAPK7 MAP4K1 HDAC5 TNFRSF1A MAP3K7 MAP2K5 IGF1 MAPK1 PI3K AKT MTOR SIGNALING AND THERAPEUTIC OPPORTUNITIES IN PROSTATE CANCER%WIKIPATHWAYS_20260710%WP3844%HOMO SAPIENS PI3K AKT mTOR signaling and therapeutic opportunities in prostate cancer FOXO1 MLST8 RPTOR TSC2 MTOR GSK3B BAD PTEN PIK3R3 FOXO4 HRAS PIK3R1 GRB10 NRAS RB1CC1 EIF4EBP1 MAPKAP1 RICTOR ULK1 PIK3CA RHEB CDKN1B TFEB PIK3R2 FOXO3A IL18 SIGNALING%WIKIPATHWAYS_20260710%WP4754%HOMO SAPIENS IL18 signaling IRF-1 NFKBIA BAX MAPK9 MAPK3 HEL-S-102 NCF1 NCF2 PRKCB TNF PRKCA LCK ACACB TICAM2 CASP8 GSK3B CASP3 RPS6KB1 IL18R1 PRKAA1 CYCS PTEN NFKB1 PIK3R1 IL18RAP CEBPB ELAVL1 SLC12A3 NFATC4 CHUK IMP3 IKBKB GRIN2B SP1 GATA1 IRAK1 CSN2 IL37 RELA TNFRSF1A MAP3K7 IL18 TNFSF6 TRAF6 MYD88 MAPK1 P53 TRANSCRIPTIONAL GENE NETWORK%WIKIPATHWAYS_20260710%WP4963%HOMO SAPIENS p53 transcriptional gene network CDK2 MLST8 CCNG1 PIDD1 NCF2 ZMAT3 SESN2 PERP DDIT4 AKT1S1 MTOR IRF9 TNFRSF10D MSH2 SESN1 GPX1 PML CX3CL1 XRCC5 CDKN1A TP53AIP1 SFN TIGAR NOTCH1 TP53INP1 XPC BBC3 GLS2 FUCA1 TNFSF6 DDB2 POLK BAX CPT1C ERCC5 THBS1 PMAIP1 AURKA TNF RPTOR TSC2 LIF RRM2B APAF1 PRKAA1 GADD45A PRKAA2 E2F7 PTEN PRKAG1 TNFRSF10B PRKAG2 ULK2 PRKAG3 DEPTOR CCL2 ISG15 TRAF4 PCNA PRKAB2 SMR3B ACAD11 CCNE1 SERPINB5 PRKAB1 SCO2 ADGRB1 DRAM1 ULK1 RPRM SIVA1 ULBP2 ULBP1 BTG2 ADORA2B TP53I3 SLC7A11 IL1 AND MEGAKARYOCYTES IN OBESITY%WIKIPATHWAYS_20260710%WP2865%HOMO SAPIENS IL1 and megakaryocytes in obesity PLA2G7 TIMP1 HBEGF TLR1 FCER1A F2 PIK3CA IRAK1 IL1R1 NLRP3 CCR3 IL1B S100A9 NFKB1 HEL-S-134P IL18 IFNG MYD88 F2R MMP9 CCL2 AGE RELATED MACULAR DEGENERATION%WIKIPATHWAYS_20260710%WP5526%HOMO SAPIENS Age related macular degeneration PRKAB2 MAPK3 PRKAB1 MLST8 PMAIP1 PPARGC1A HEL-S-32 MTOR RPTOR RPS6KB1 PRKAA1 PRKAA2 PRKAG1 PARP2 PRKAG2 SIRT1 PRKAG3 PROGERIA ASSOCIATED LIPODYSTROPHY%WIKIPATHWAYS_20260710%WP5103%HOMO SAPIENS Progeria associated lipodystrophy LMNB2 LMNA FFAR3 SMAD2 TGFB1 MUCL3 SPRTN SMAD4 ZMPSTE24 BANF1 KCNJ6 FNTA ICMT FBN1 INS WRN RECQL PPARG MITOCHONDRIAL COMPLEX II ASSEMBLY%WIKIPATHWAYS_20260710%WP4920%HOMO SAPIENS Mitochondrial complex II assembly SDHAF2 SDHAF3 SDHAF1 SDHAF4 SDHC SDHD SDHB SDHA MAMMARY GLAND DEVELOPMENT PREGNANCY AND LACTATION STAGE 3 OF 4%WIKIPATHWAYS_20260710%WP2817%HOMO SAPIENS Mammary gland development pregnancy and lactation stage 3 of 4 BCL2L1 ERBB2 USF2 PRLR NR3A2 PGR NR3C1 CCND1 GJB2 YY1 PRL EIF4E NFIB NRG1 CEBPB ERBB3 EGFR ERBB4 TNFSF11 CHUK CSN2 TPM3 TNFRSF11A EIF4G1 DLGAP4 TFPI2 CEBPA CLDN6 USF1 TTC9 GAL MYC ELF5 HDGFL2 ORAI1 STAT5B PTPN1 NFIA SEROTONIN AND ANXIETY%WIKIPATHWAYS_20260710%WP3947%HOMO SAPIENS Serotonin and anxiety HTR1A ARC CRH PLCD4 PRKCB ADRA1A POMC TRPV1 EEF2K FOS PPP3CA FMR1 HTR2A PLEK HYPOTHETICAL CRANIOFACIAL DEVELOPMENT PATHWAY%WIKIPATHWAYS_20260710%WP3655%HOMO SAPIENS Hypothetical craniofacial development pathway TP63 TFAP2A ARHA IRF6 ARHGAP29 ARHGEF2 GABA METABOLISM AKA GHB %WIKIPATHWAYS_20260710%WP4157%HOMO SAPIENS GABA metabolism aka GHB ABAT ALDH5A1 GLS2 PON3 ADHFE1 HEL-S-166mP GAD1 GAD2 GLS PLEURAL MESOTHELIOMA%WIKIPATHWAYS_20260710%WP5087%HOMO SAPIENS Pleural mesothelioma MEF2D AGER COL4A4 COL4A3 COL4A5 PS1TP5BP1 FOXO1 LAMA5 LRP6 PORCN LAMB2 FZD1 CSNK1A1 FZD7 FZD8 SFRP4 FZD2 BRCA1 IGF1R FLT4 CDH9 CDH8 CDH6 MMP14 WWC1 CDH4 TEAD2 TEAD3 TEAD4 EED LATS1 MDK LATS2 ANGPT1 SLC7A5 FGFR1 CDH10 CDH11 KIT CDH12 CDH15 CDH16 CDH17 FGF8 CDH19 EPHA2 YAP1 CDH24 WWTR1 MAX NF2 FGFR3 LIMD1 HEL-S-104 FZD9 YY1 LAMA4 LAMC1 FZD10 BARD1 COL4A2 COL4A1 INS DDIT3 SETD5 FGF19 FGF21 FGFR4 SLC3A2 MAP3K6 FLT3 ACTG2 SETDB1 TGFA MAP3K10 GABPA MAP3K11 PDGFD HEL-S-31 PDGFC IGF2 ACTA2 MAP4K1 MAP4K2 ACTA1 MINK1 PRB1 TNNT1 PRB2 MAP4K3 MAP3K2 RPS6KB2 CD47 NTF3 PIGF FGF3 CHD8 FGF6 FGF9 COL4A6 CIT EFNA5 EFNA4 AMOT FGF20 FGF22 CYCS FGF17 EFNA1 EFNA3 CSF1 FGF14 CTBP2 EFNA2 FGF18 RB1CC1 FGF13 FGF12 LAMC2 SOST DKK1 LAMA1 LAMA3 LRP5 BMI1 ANGPT4 ANGPT2 CTHRC1 LAMB3 LAMB1 IGF1 AJUBA SUZ12 RNF2 ITGB4 PPARGC1A AKT3 ASXL1 WDR5 BAP1 DKFZp781B1423 ITGAV FGF2 HRAS DEPTOR MAP2K1 MAP2K2 ITGA4 CDK4 ITGA2 ITGA1 KMT2C FGFR2 CTBP1 hCG_2014051 ITGA6 SOS1 RYK ROR1 ROR2 SHC1 NLRP3 SRC MAPK7 PAK6 CD44 MAP2K5 RASSF2 PAK4 RASSF3 RASSF4 RASSF6 FZD3 PHC1 NGFR PRSS23 MAPK10 RING1 MAD2L1 DSC3 GRB2 BAG2 MOBKL1A MLST8 CSNK2B AKT1S1 CER1 IDO1 CCL4 KREMEN1 SENP2 SFRP5 NTRK1 CXXC4 RPS6KA5 NOTUM BTC MAPKAPK2 CSF2 EIF4G1 SFRP1 IL34 CSF3 JAK1 WIF1 DKK2 CSF1R KIF23 EGF RPTOR STAT1 CCND1 TTI1 KDR GSK3B PRKAA1 MCU PRKAA2 BTRC PTEN PRKAG1 DKK4 RPS6 PIK3CD PRKAG2 TSC1 ULK2 PRKAG3 KITLG EIF4EBP1 CREB1 NTRK2 PRKAB2 NGF CCNE1 BDNF PRKAB1 ULK1 RAF1 RASSF1 PIK3CA RHEB HIF1A OGT EZH2 FLT1 CTGF PAK1 HGF CCL5 MMP9 MAPK1 VEGFA CDK2 MAPK3 MOB1A CTNNA1 CTNNA3 CTNNA2 MTOR PLCB4 RPS6KB1 MAD1L1 SOX17 RBBP4 FGF23 ATF2 CDKN1A EGFR MAPK8 FGF7 BAK1 MAP3K5 FZD5 MCL1 MAP2K6 HEL-S-1 UHRF1 MAP2K3 MAP2K4 PDGFRA WNT2B JUN CDKN2A MMP2 HMGB1 TRAF2 BBC3 MAPK14 FRAT1 CCND3 SETD2 CCND2 MYC IL6 PDGFA WNT5B FGF4 AXIN1 NTF4 HMGN1 WNT16 BCL2 FLT3LG LEF1 BAX CDK7 FGF10 HBEGF MAPK9 DVL1 DVL2 ITGB3 DVL3 FRAT2 WNT1 WNT3 RPS6KA1 HCFC1 WNT4 WNT10B MMP3 SELE TCF7L2 CSNK1A1L TERT WNT10A TSC2 TCF7L1 AREG MAP3K1 CDH18 WNT3A IL1B WNT7B INSR WNT7A NFKB1 FOSL1 CXCL1 APC CXCL5 RASSF7 CCL2 MDM2 LGALS9 ATM STK38L VEGFB TNIK VEGFC SP1 VEGFD CXCL12 IL10 CSNK2A1 FOXM1 CSNK2A3 VGLL4 TGFB1 CSNK2A2 LIN28B ITGB1 CDH2 SPARC ATF3 ACTG1 EIF4B EPITHELIAL TO MESENCHYMAL TRANSITION IN COLORECTAL CANCER%WIKIPATHWAYS_20260710%WP4239%HOMO SAPIENS Epithelial to mesenchymal transition in colorectal cancer MEF2D COL4A4 GDF15 COL4A3 COL4A5 GRB2 ID1 HEL-S-79 CLDN2 CDKL2 CLDN9 PKP1 LRP6 EIF5A2 VTN CLDN22 RBPJ CLDN20 CLDN24 FZD1 CLDN23 CLDN10 CLDN15 FZD7 CLDN14 CLDN19 FZD8 STRAP CLDN18 TUSC3 CLDN17 CLDN16 CRB3 CLDN3 FZD2 NR2C2 TWIST1 JAG2 TMPRSS4 DLL3 EED LATS2 CLDN7 NUBPL TGFBR1 TGFBR2 ZEB2 CLDN11 SMAD2 GSK3B GIG8 FZD9 WNT9B PIK3CD FZD10 PIK3R3 COL4A2 NOTCH3 PKD1 COL4A1 NOTCH4 WNT9A DLL4 PIK3R1 WNT8B CLDN4 RAF1 PIK3CA PALS1 HIF1A EZH2 MMP15 PAK1 PKP2 NRP2 MMP9 MAPK1 SNAI1 PROX1 MAPK3 SNAI2 COL4A6 TWIST2 JUP RBBP4 CTDSP1 MAPK8 FZD5 MAP2K6 MAP2K3 FZD4 MAP2K4 NOTCH1 WNT2B TJP1 LRP5 MMP2 MAPK14 MAPK12 FMNL2 MAPK13 MAPK11 WNT5B FOXQ1 TRAF6 WNT16 SOS2 SUZ12 WNT1 FOXC2 WNT3 WNT4 WNT10B WNT10A SMAD4 AKT3 WNT3A WNT7B WNT7A HRAS MAP2K1 MAP2K2 CLDN5 SOS1 FOXM1 TGFB1 SHC1 PIK3R2 CDH2 CLDN6 NOTCH2 SPARC WNT8A CLDN1 FZD3 NF KB SIGNALING AND ARTD FAMILY MEMBERS%WIKIPATHWAYS_20260710%WP5527%HOMO SAPIENS NF kB signaling and ARTD family members NFKBIA TBK1 PARP10 SKP1 GSK3B EP300 BTRC ZC3HAV1 TIPARP NFKB2 PARP16 ERN1 PARP12 CREBBP PARP14 CHUK IKBKB MAP3K14 IKBKG TFPI2 CLDN6 RELB MAVS RBX1 RIGI CYTOSINE METHYLATION%WIKIPATHWAYS_20260710%WP3585%HOMO SAPIENS Cytosine methylation TET1 TDG HEL-S-26 TET2 MBD3 PRION DISEASE PATHWAY%WIKIPATHWAYS_20260710%WP3995%HOMO SAPIENS Prion disease pathway TBP BCL2 BATF MAPK3 IRF4 SMC3 MEF2C FYN CTCF CASP12 CASP3 EP300 NFKB1 HEL-S-89n HEL-S-269 RAD21 STAT3 RFX5 CREB1 RXRA PRNP NCAM1 PAX5 HEL-S-125m FGFR1 CHD2 POU2F2 SPI1 MAPK1 FANCONI ANEMIA%WIKIPATHWAYS_20260710%WP5465%HOMO SAPIENS Fanconi anemia SLX4 ERCC1 RFWD3 RAD50 CTDP1 SMARCA4 RAD51 MRE11A NBN BRCA2 REV1 PTEN RAD51C UBE2T MEN1 FAAP24 BRIP1 CEBPD DCLRE1B BRCA1 FANCD2 UHRF2 EGFR FANCM ATM CENPX FANCL FAN1 FANCA FANCB USP1 FANCE PALB2 ATR FANCG FANCF UHRF1 CENPS HEL-S-125m MCM2 MAD2L2 THYROXINE THYROID HORMONE PRODUCTION%WIKIPATHWAYS_20260710%WP1981%HOMO SAPIENS Thyroxine thyroid hormone production MAP2K2 DUOX1 CREB1 CLCN5 MAPK3 CGA HEL-S-5 TRH RAF1 TPO PRKCA PRKAA1 RAP1A PRKAA2 SLC5A5 DUOX2 NFKB1 TSHR TG MAP2K1 MAPK1 HEPATOCYTE GROWTH FACTOR RECEPTOR SIGNALING%WIKIPATHWAYS_20260710%WP313%HOMO SAPIENS Hepatocyte growth factor receptor signaling MAPK3 GRB2 PTGS2 PTEN HRAS MAP2K1 STAT3 MAP2K2 CRKL MAPK8 ITGA1 RAPGEF1 SOS1 RAF1 PIK3CA CRK PTK2B DOCK1 JUN SRC PXN ITGB1 FOS RAP1A MAP4K1 PAK1 HGF MAPK1 PTPN11 LEUKOCYTE INTRINSIC HIPPO PATHWAY FUNCTIONS%WIKIPATHWAYS_20260710%WP4542%HOMO SAPIENS Leukocyte intrinsic Hippo pathway functions YWHAQ MOB1A FOXO1 CCR7 RAC1 ARHA FOXO4 FOXO6 STK38L FYB1 FOXP3 KNSTRN RAB13 FERMT3 TEAD2 TEAD3 TEAD4 LATS1 LATS2 CD19 RAP1A MAPK14 LPL FOXO3A YAP1 WWTR1 MIRNA ROLE IN IMMUNE RESPONSE IN SEPSIS%WIKIPATHWAYS_20260710%WP4329%HOMO SAPIENS miRNA role in immune response in sepsis IRF-1 NFKBIA VCAM1 TNF CCL4 CCL3 TRAF3 NFKB1 CXCL8 NFKB2 ELANE TLR4 MAPK8 CHUK IRAK4 MAP3K7IP1 IKBKB IL1A IRF7 TLR7 TLR8 IKBKG IL10 IRAK1 MAPK14 RELA RELB MAP3K7 IL6 REL LCN2 TRAF6 MYD88 NITRIC OXIDE METABOLISM IN CYSTIC FIBROSIS%WIKIPATHWAYS_20260710%WP4947%HOMO SAPIENS Nitric oxide metabolism in cystic fibrosis NOS2 PRMT2 CARM1 PRMT6 HEL-S-277 PRMT7 PRMT1 PRMT3 METHIONINE METABOLISM LEADING TO SULFUR AMINO ACIDS AND RELATED DISORDERS%WIKIPATHWAYS_20260710%WP4292%HOMO SAPIENS Methionine metabolism leading to sulfur amino acids and related disorders HEL-S-182mP MTR MAT1A CBS pcap CTH ADK CDO1 HEL-S-61p PHOSPHATIDYL INOSITOL PHOSPHATE PATHWAY%WIKIPATHWAYS_20260710%WP5411%HOMO SAPIENS Phosphatidyl inositol phosphate pathway PIP4P1 PIP4K2A PIP4K2B PIP5K1C SACM1L PIKFYVE MTMR2 PLCD3 PLCD4 INPP5D OCRL FIG4 PLCB3 PLCB4 PLCG1 PTEN PLCB1 PIK3CD PLCB2 PLCG2 INPP5E STM7 PIK3CA PI4K2B TPTE2 PIP5K1A PI4KB PIK3C2G PI4K2A IPMK PIK3C2B MTMR1 PLCE1 MTMR8 INPP4B MTMR6 MTM1 INPP4A PIP4P2 ERK PATHWAY IN HUNTINGTON 39 S DISEASE%WIKIPATHWAYS_20260710%WP3853%HOMO SAPIENS ERK pathway in Huntington 39 s disease MAP2K2 EGFR NTRK2 CREB1 BDNF MAPK3 RAF1 EGF CASP3 HTT RPS6KA5 HRAS MAP2K1 MAPK1 TRIACYLGLYCERIDE SYNTHESIS%WIKIPATHWAYS_20260710%WP325%HOMO SAPIENS Triacylglyceride synthesis AGPAT4 PLPP3 PLPP2 LIPF LIPE GPAM PNPLA2 MOGAT3 AGPAT5 DGAT1 MOGAT2 MOGAT1 AGPAT3 DGAT2 GNPAT GPD1 PLPP1 LPL LIPC BIOGENIC AMINE SYNTHESIS%WIKIPATHWAYS_20260710%WP550%HOMO SAPIENS Biogenic amine synthesis PNMT AANAT PAH ACHE ASMT HDC DBH DDC TPH1 MAOA GAD1 ChAT TH GAD2 INTEGRATIVE ANALYSIS OF TREG GLIAL INTERACTIONS %WIKIPATHWAYS_20260710%WP5561%HOMO SAPIENS Integrative Analysis of Treg Glial Interactions VEGFA CD47 AIF1 OSM PDCD1 FOXO1 NKX6-1 HEL-S-111 CCL1 APOD ROS1 SIRPA CCR8 TLR4 STAT3 EGFR IL10RB IGF1R FOXP3 PDGFRA IKZF2 MAPK14 CCN3 EBI3 CCR6 NKX6-2 IL2 IL2RG KLRG1 OLIG2 MCAM SOCS3 TMEM119 FOXO3A JAK1 IL18 IL6 JAK3 PDGFA CD68 IFNG STAT5B IGF1 TYK2 opn STAT4 TGFBR1 GSDMD TGFBR2 TGFBR3 IL33 ITGB3 TNF SMAD2 CNP STAT1 AREG IL12RB1 NKX2-2 MOG RAC1 TNFRSF1B IL1B ITGAV NFKB1 NFKB2 SSTR2 FOXO4 CXCL1 NOS2 CCL20 ITGA2 IL10RA CXCL12 SOX9 FAM20C IL10 CX3CR1 IL4 HTR7 TGFB1 CD80 CTLA4 OLIG1 IL12A NLRP3 IL2RA IL2RB CSPG4 CD44 MBP MYD88 MMP9 CDC42 NUCLEOTIDE BINDING OLIGOMERIZATION DOMAIN NOD PATHWAY%WIKIPATHWAYS_20260710%WP1433%HOMO SAPIENS Nucleotide binding oligomerization domain NOD pathway RIPK2 CARD6 NFKBIA ACAP1 NLRP1 NLRP10 CASP5 NDUFA13 NAIP CASP9 CASP8 RAC1 IL1B ERBIN AIM2 NOD2 PYCARD CHUK IKBKB NLRP12 IKBKG NLRP3 NLRP7 NLRP2 COPS6 RELA DUOX2 NOD1 NLRC4 IL18 MEFV AAMP CARD8 CARD9 LUPUS PATHOGENESIS%WIKIPATHWAYS_20260710%WP5559%HOMO SAPIENS Lupus pathogenesis ICOS PDCD1 TLR9 TLR7 TNLG7A CD40LG CD80 IL17A CD40 BCR IFNA2 TNFRSF13C IL6 TLR4 TRANSCRIPTION CO FACTORS SKI AND SKIL PROTEIN PARTNERS%WIKIPATHWAYS_20260710%WP4533%HOMO SAPIENS Transcription co factors SKI and SKIL protein partners LATS2 HDAC3 SKI HDAC1 MERTK SKIL TEAD2 TEAD3 TEAD4 SIN3A LATS1 NF1 NUCLEOTIDE GPCRS%WIKIPATHWAYS_20260710%WP80%HOMO SAPIENS Nucleotide GPCRs P2RY4 P2RY2 ADORA2A P2RY1 LTB4R ADORA2B P2RY6 LPAR4 HSPB3 IN CHARCOT MARIE TOOTH DISEASE%WIKIPATHWAYS_20260710%WP5524%HOMO SAPIENS HSPB3 in Charcot Marie Tooth disease LBR HSPB2 DMPK HP1BP3 HSPB3 LMNA MEF2C MYOG MYOD1 HEL25 DES ACTA1 NOTCH3 H2AZ1 16P11 2 DISTAL DELETION SYNDROME%WIKIPATHWAYS_20260710%WP4950%HOMO SAPIENS 16p11 2 distal deletion syndrome IFITM1 GRB2 NFATC2IP SDCCAG8 TUFM ATXN2L SPNS1 RAB4A NFATC2 RAB5A CR2 KDR ATP2A1 TRAF1 INSR PRMT1 SLN CD81 PLN SH2B1 VAV2 RABEP2 IL4 CD82 HEL-S-62p CD19 TRAF2 LAT MPL PROXIMAL TUBULE TRANSPORT%WIKIPATHWAYS_20260710%WP4917%HOMO SAPIENS Proximal tubule transport SLC5A1 ABCB1 ATP1B1 SLC7A7 ATP6V0D2 SLC47A2 ATP6V1A SLC22A6 SLC47A1 HEL-76 AQP1 CA4 ATP6V0A4 ATP6V1D ATP6V0E1 SLC22A11 SLC2A2 SLC4A4 ATP6V1G1 ATP6V0B ATP6V0C SLC34A3 ATP6V1B1 SLC6A18 FXYD2 SLC5A8 SLC22A2 ATP6V1C1 SLC5A2 ABCC2 SLC6A20 SLC9A3 ATP6V1E1 SLC6A19 SLC3A2 ATP1A1 SLC34A1 ATP6V1F SLC22A7 SLC5A5 ABCG2 SLC36A2 CLTRN SLC16A10 SLC7A9 SLC1A1 SLC3A1 GPCRS OTHER%WIKIPATHWAYS_20260710%WP117%HOMO SAPIENS GPCRs other GPR17 CNR1 CHRM2 GPR18 OR2F1 GPR143 IL8RB HTR2A CCKBR HTR1F ALG6 FSHR OR3A3 OR3A1 CELSR2 P2RY13 P2RY11 CCR5 CELSR1 GPR183 CXCR1 S1PR1 CHRM3 SMO C5AR2 CXCR3 GPR83 OR2M4 CCR2 ADORA2A GPR61 GPR62 CELSR3 RXFP3 UTS2R GPR176 OR2B6 GPR132 DRD3 GPR135 SSTR2 DRD4 ADGRV1 TAAR5 OR1J2 TAAR2 GNRHR OR1N1 GPR162 OR1R1 OR5AC2 OR2A4 ADGRF5 VN1R1 GRPR OR10A2 OR1G1 OR6C3 OR6C2 EDNRA OR8G1 GPR88 GPR84 HTR7 MCHR2 GHRHR OR5D3 OR1F1 GPR55 EMR3 OR2H1 ADGRD1 OR2A5 LGR6 PTGFR ADGRL2 ADGRL3 OR7E24 ADRA1D OR10A5 ADRB2 OR1E1 F2R NTSR1 OSTEOCLAST SIGNALING%WIKIPATHWAYS_20260710%WP12%HOMO SAPIENS Osteoclast signaling opn MAPK8 TNFSF11 ITGB3 IFNB1 TNFRSF11B IFNAR1 TRPV5 ATP6V1G1 TNFRSF11A ACP5 AIMP2 GPR68 CTSK PERTURBATIONS TO HOST CELL AUTOPHAGY INDUCED BY SARS COV 2 PROTEINS%WIKIPATHWAYS_20260710%WP4936%HOMO SAPIENS Perturbations to host cell autophagy induced by SARS CoV 2 proteins GABARAPL2 APOB ATG2B PPP1R9A ATG16L1 MLST8 VPS18 LAMTOR1 NBR1 AKT1S1 HEL-S-30 RPTOR MTOR RPS6KB1 PRKAA2 LARP1 RPS6 VPS16 DEPTOR DKFZp686F0183 VPS39 VPS41 RB1CC1 LAMP2 VPS33A CALCOCO2 ATG3 DKFZp762B153 ATG12 ULK1 RHEB SQSTM1 ATG9A OPTN RAB7A VAMP8 TMEM59 EIF4B ANDROGEN BIOSYNTHESIS%WIKIPATHWAYS_20260710%WP5393%HOMO SAPIENS Androgen biosynthesis POR AKR1D1 HSD3B2 CYP3A4 CYP17A1 CYP3A7 HSD17B3 HSD17B4 HSD17B1 AKR1C1 HSD17B2 HSD3B1 AKR1C2 AKR1C4 SRD5A2 SULT2A1 HSD11B1 HSD11B2 HEDGEHOG SIGNALING%WIKIPATHWAYS_20260710%WP47%HOMO SAPIENS Hedgehog signaling SHH PTCH1 PTCH2 KIF7 SMO DHH SAP18 GLI3 SIN3A SUFU ADRBK1 SOMATIC SEX DETERMINATION%WIKIPATHWAYS_20260710%WP4814%HOMO SAPIENS Somatic sex determination NR5A1 SOX9 DHH FGF9 WNT4 RSPO1 SOX8 WT1 DMRT1 SRY FOXL2 GATA4 AMH TLR4 SIGNALING AND TOLERANCE%WIKIPATHWAYS_20260710%WP3851%HOMO SAPIENS TLR4 signaling and tolerance NFKBIA TBK1 IFNB1 TNF IRF3 INPP5D RIPK1 TICAM1 IKBKE TRAF3 NFKB1 CXCL8 TLR4 TRAM1 CHUK IRAK3 IRAK4 MAP3K7IP1 IKBKB TIRAP IRF7 IKBKG IRAK1 MAP3K7 IL6 TRAF6 MYD88 UREA CYCLE AND METABOLISM OF AMINO GROUPS%WIKIPATHWAYS_20260710%WP497%HOMO SAPIENS Urea cycle and metabolism of amino groups ARG1 HEL-S-20 NAGS ASS1 SMS ALDH18A1 HEL-S-5 GLUD1 ARG2 HEL-S-29 SRM OTC ASL GLUCOSE METABOLISM IN TRIPLE NEGATIVE BREAST CANCER CELLS%WIKIPATHWAYS_20260710%WP5211%HOMO SAPIENS Glucose metabolism in triple negative breast cancer cells HEL-S-30 PFKP HEL-S-133P PPM2C DIET DEPENDENT TRIMETHYLAMINE TRIMETHYLAMINE N OXIDE METABOLISM %WIKIPATHWAYS_20260710%WP5219%HOMO SAPIENS Diet dependent trimethylamine trimethylamine N oxide metabolism CHDH ALDH7A1 SLC44A1 COMPLEMENT SYSTEM%WIKIPATHWAYS_20260710%WP2806%HOMO SAPIENS Complement system HEL-S-92n FCER2 FKBP2 F11 CFHR2 CFHR4 C4A FGA DKFZp686L0365 LAMA5 SELPLG IBSP VTN PRKCA CFB GNA15 CFH CSNK1A1 CD40 CRP CFI CFP SELL CLEC4M ICAM2 HEL-S-78p CPN1 FCN2 RPS19 SERPING1 C4BPA KLKB1 PRNP C8A ADM C1QBP FCGR3A CD59 LAMB1 opn DCN GNAI3 ITGB3 THBS1 ITGA2B C1S C5AR2 C5AR1 SELE C3AR1 CR2 PTX3 SFTPA1 F13A1 LAMC1 PROS1 TXN ELANE MBL2 MASP2 ITGA2 MASP1 FCN1 CD46 CFD PLG C6 C7 SFTPA2 C9 CD55 F10 HEL-S-62p CD19 HEL-S-99n FPR1 SELP WAS CR1 ALB VSIG4 PLAUR CD93 NO CGMP PKG MEDIATED NEUROPROTECTION%WIKIPATHWAYS_20260710%WP4008%HOMO SAPIENS NO cGMP PKG mediated neuroprotection PDE2A NFKBIA BCL2 GUCY1A2 PDE3A GUCY1B1 CNGB1 CNGA3 CNGA4 CNGB3 TNF NEFL AKAP9 CASP9 CYCS NPPB BAD NPPA IL1B NFKB1 CAMK2D CALM1 CAMK2A NOS2 CREB1 CAMK2G GRIN2B GRIN1 PBR DLG4 RELA CNGA1 ACTN2 IFNG MIR TARGETED GENES IN SQUAMOUS CELL%WIKIPATHWAYS_20260710%WP2006%HOMO SAPIENS miR targeted genes in squamous cell ELOVL5 TUBA1A YWHAQ ANP32B HEL-S-30 PRPF40A NCL NRP1 GFPT1 GAS2L1 AXL POLR2C NEDD4 TMED10 SYNE2 NF2 SPTLC1 TGFBR2 CPNE8 VEZT PWP1 SLC38A1 THBS1 CIAO2A ATP6V0E1 POLD2 AKAP8 FNDC3B FNDC3A LAMC1 SEC23A PDLIM7 UBE2J1 TNFRSF10B FBXW11 MRPL20 COMMD9 PNP ATP6V1C1 PISD TRAM1 SLC12A2 MAGT1 MRC2 RNP24 MAP3K8 RHEB ATP2A2 TPM3 CSDE1 PXDN GOLGA7 TPM1 GYS1 ATP6V1F PPP1R7 MPZL1 TMEM59 ARCN1 ARF4 ANXA2 SDCBP HMOX1 LAMTOR5 POGLUT3 SH3BGRL3 RARS1 VCAM1 DHX57 HOXA7 PEDS1-UBE2V1 AP2A1 MRPS33 RAI14 CBFB PTMA ADIPOR2 HMGA1 GALNT1 SLC4A10 CHMP2A HEL-S-26 SRPRB DKFZp761E1322 CTDSP1 MOV10 HSD17B12 DNAJB1 SH3BP4 TBCA GALNT7 FMNL2 BET1 SMAD1 E2F3 P4HA2 TMEM43 PICALM SRSF9 CUL4B FGF2 TMED7 RTN4 AP3D1 SPCS3 ADAR POM121 HES1 AMINO ACID METABOLISM%WIKIPATHWAYS_20260710%WP3925%HOMO SAPIENS Amino acid metabolism PNMT SMS RARS1 TPH1 EHHADH ACADM MARS2 ASNS HEL-S-32 PPM1L VARS1 HEL-S-30 IARS HAL GPT2 G6PC2 HEL-75 HEL-S-26 HMGCL GCLM HEL-S-53e ADH1C ADH5 ARG1 ADH7 HEL-S-4 HDC OGDH SUCLG1 GLUD1 GOT2 ARG2 ALDH7A1 DLD MAOA SDHA ACO2 PDHX CS CBS HEL-S-64p PCK1 PDHA1 MDH2 HEL-S-133P ASS1 P4HA2 ALDH18A1 DBH DDC PC CTH TDO2 MCCC1 SRM OTC ACLY TH LARS2 FH PDK4 CAD TPO HEL-S-61p PIG59 FTCD EPRS1 BCAT1 FARSB GLS ACSS1 RANKL RANK SIGNALING%WIKIPATHWAYS_20260710%WP2018%HOMO SAPIENS RANKL RANK signaling NFKBIA GAB2 MAPK9 MAPK3 TNFRSF11B STAT1 MTOR PLCG1 RAC1 TRAF1 TRAF3 NFKB1 NFKB2 PIK3R1 MAP2K1 MAPK8 TNFSF11 CHUK MAP3K7IP1 PAPSS2 IKBKB IKBKG MAP2K6 SYK SQSTM1 JUN SRC TNFRSF11A TRAF2 PIK3R2 FOS MAPK14 RELA FHL2 CBL RELB LYN MAP3K7 SPI1 NFATC1 TRAF6 CDC42 MAPK1 TRAF5 TYPE I COLLAGEN SYNTHESIS IN THE CONTEXT OF OSTEOGENESIS IMPERFECTA%WIKIPATHWAYS_20260710%WP4786%HOMO SAPIENS Type I collagen synthesis in the context of osteogenesis imperfecta PLOD1 COL1A1 COL1A2 ADAMTS2 P4HA1 P4HA2 TNFRSF11B SP7 WNT1 LRP6 PPIB FZD1 MIA3 TMEM38B COLGALT1 IFITM5 CRTAP MBTPS1 P3H2 P3H1 PLOD2 MBTPS2 BMP1 TNFSF11 LRP5 TNFRSF11A 8P23 1 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260710%WP5346%HOMO SAPIENS 8p23 1 copy number variation syndrome MCRS1 MAPK3 FCGR2A HSPD1 MSRA NKX6-1 BLK CLDN23 TNKS SOX7 PINX1 HEPACAM2 C8orf7 SLC35G5 TERF1 SLBP GATA4 PRSS55 CSTA ERI1 TLR4 PRSS51 DEFB136 C8orf74 BMP1 DEFB135 DEFB134 MFHAS1 FAM167A PDX1 MTMR8 MTMR9 AXIN1 MTMR6 NUMA1 S100A10 SLC2A4 TBX5 TERT PPP1R3B HEL-S-130P RP1L1 NEIL2 CGAS FDFT1 RAF1 SGPL1 FCGR2B MAPK1 CONSTITUTIVE ANDROSTANE RECEPTOR PATHWAY%WIKIPATHWAYS_20260710%WP2875%HOMO SAPIENS Constitutive androstane receptor pathway ALAS1 NCOA1 ABCB1 FOXO1 CYP2C19 DNAJC7 PPARGC1A EHHADH SULT1A1 PTPA UGT1A1 CYP2B6 NCOA6 ABCC3 CYP2A6 SMC1A ABCC2 NR1I3 CYP4A11 SP1 RXRA CYP3A4 CYP2C9 UGT1A4 UGT1A3 UGT1A9 SULT2A1 GENES TARGETED BY MIRNAS IN ADIPOCYTES%WIKIPATHWAYS_20260710%WP1992%HOMO SAPIENS Genes targeted by miRNAs in adipocytes GJA1 HAND2 TMSB4X HCN4 ERG KCNE1 HCN2 IGF1 KCNJ2 LIVER X RECEPTOR PATHWAY%WIKIPATHWAYS_20260710%WP2874%HOMO SAPIENS Liver X receptor pathway CYP2B6 SCD RXRA FASN NR1H3 CYP3A4 CYP7A1 ABCG8 ABCG5 VITAMIN D RECEPTOR PATHWAY%WIKIPATHWAYS_20260710%WP2877%HOMO SAPIENS Vitamin D receptor pathway THBD ID1 CASP5 FOXO1 CLDN2 CD14 CD40 IGFBP5 HLA-DQA2 HLA-DQA1 NR1C2 SFRP1 PRKCQ STS CBS CCNC SULT2A1 ALPI opn MED9 PTH IRF4 IRF8 PTHLH SLC2A4 TNLG2B ADAMTS5 CYP27B1 CYP2B6 SALL4 CCND1 HNF1A CAMP S100A6 TRAK1 S100A9 DUSP10 SOSTDC1 DND1 EPHB4 KLF4 CCNE1 COLEC11 CYP2C9 IL1RL1 SLC8A1 S100A8 ID4 CYP2S1 TPM1 CYP1A1 HIF1A HSD17B2 HILPDA TIMP3 ADRB2 SULT1C2 CDK2 BGLAP MX2 CDKAL1 NFATC2 EFNA5 KL FGF23 CDKN1A NR1i1 TNFSF11 KNG1 PTGER4 CLEC16A JUNB HLA-DRB1 BDKRB1 ATP2B1 LPGAT1 CYP3A4 STEAP4 GXYLT2 CYP7A1 KRT71 SLC34A2 LCE1F LCE1D LCE2B CDKN1B CDC34 LRP5 CDKN2A NINJ1 S100A4 COL13A1 KLK6 CRACR2A CRACR2B CEBPA KRTAP4-1 SLC37A2 MYC KRTAP12-2 BTLA KRTAP8-1 TRPV6 PNOC CLPTM1L ALPG CDKN2D BMP6 ZNF257 CD200 ORM1 ORM2 CASP14 ADGRE5 CYP24A1 DACT2 KRTAP5-1 CST6 CDX2 ABCB1 CA9 TNFRSF11B ABCD1 DEFB4B ITGAM KRTAP5-4 KRT34 MXD1 CEACAM1 KRT38 SATB1 S100A2 HEL57 SEMA3B TRPV5 ASAP2 CST1 CLMN CREG2 GADD45A LRRC25 S100G IGFBP1 KRTAP10-2 KRTAP10-4 KRTAP10-7 KRTAP10-9 SPRR1B KRT13 MYO9B IL25 DEFB132 KRT16 BCL6 TNFAIP3 CD9 TREM1 CDKN2B LGALS9 CDKN2C G0S2 RXRA ADRA1B DNER TGFB1 CTLA4 IL12A ALOX5 REGULATION OF SISTER CHROMATID SEPARATION AT THE METAPHASE ANAPHASE TRANSITION%WIKIPATHWAYS_20260710%WP4240%HOMO SAPIENS Regulation of sister chromatid separation at the metaphase anaphase transition ESPL1 BUB1B MAD2L1 MAD1L1 CENPE STAG1 SMC3 CDC20 PTTG1 SMC1A APC RAD21 BIOMARKERS FOR PYRIMIDINE METABOLISM DISORDERS%WIKIPATHWAYS_20260710%WP4584%HOMO SAPIENS Biomarkers for pyrimidine metabolism disorders RRM2B DPYD TYMS UMPS HEL74 DPYS DHODH TYMP NT5C3A RRM2 RRM1 HEL-S-29 DISORDERS OF FOLATE METABOLISM AND TRANSPORT%WIKIPATHWAYS_20260710%WP4259%HOMO SAPIENS Disorders of folate metabolism and transport SLC19A1 SLC46A1 HEL-S-70p MTR MTHFS TYMS SHMT1 FTCD HEL-S-51e DHFR MTHFD1 MTHFD2L MTHFD2 FOLR1 OVERLAP BETWEEN SIGNAL TRANSDUCTION PATHWAYS CONTRIBUTING TO LMNA LAMINOPATHIES%WIKIPATHWAYS_20260710%WP4879%HOMO SAPIENS Overlap between signal transduction pathways contributing to LMNA laminopathies LEF1 opn TARBP2 KAT2B BMP2 PS1TP5BP1 LMNA TNFRSF11B AGO2 SMAD2 WNT10B TCF7L2 CSNK1A1L MYOD1 TCF7L1 CSNK1A1 GSK3B MSTN HDAC1 FNTA ICMT WNT7B APC RB1 CEBPB CEBPD CTSK PPARG CDKN1A CREBBP CDK4 JUNB RUNX2 NOTCH1 MAOA TGFB1 HMGA2 ZMPSTE24 EMD CEBPA LEMD3 HES1 DICER1 AXIN1 HES5 IRON SULFUR CLUSTER BIOGENESIS%WIKIPATHWAYS_20260710%WP5152%HOMO SAPIENS Iron sulfur cluster biogenesis LYRM4 ABCB7 FDX1 FDXR CIAO2B FXN NUBP1 NUBP2 HSCB NFU1 ISCU NARF PGK1 PKM2 KHKC KHKA ACTING AS PROTEIN KINASES%WIKIPATHWAYS_20260710%WP5433%HOMO SAPIENS PGK1 PKM2 KHKC KHKA acting as protein kinases HEL-S-30 H2AX H3F3B KHK HEL-S-68p MYL2 SNAP23 AKT1S1 STAT3 AXON GUIDANCE%WIKIPATHWAYS_20260710%WP5289%HOMO SAPIENS Axon guidance SLIT1 SLIT3 L1CAM RHOD FYN NCK1 PARD3 PRKCA MYL12B EFNA1 BMPR2 RRAS NRP1 EPHB1 ROBO1 DCC PARD6A SEMA3A SLIT2 HEL-S-15 PTCH1 EPHA2 SHH FES BOC CXCR4 TRPC1 ROBO2 WNT4 GNAI1 CDK5 GSK3B RAC1 HRAS PRKCZ NTN3 PDPK1 ARHGEF12 HEL-S-28 SEMA5B ROBO3 CXCL12 DPYSL5 UNC5D RAF1 SEMA7A EFNB1 RYK ABLIM3 LRIG2 SRGAP2 NTNG2 SRC NGL1 ITGB1 ROCK1 gdf7 PLXNA1 RGMA CDC42 MAPK1 FZD3 TCA CYCLE IN SENESCENCE%WIKIPATHWAYS_20260710%WP5050%HOMO SAPIENS TCA cycle in senescence FH PDP2 ME2 ME1 PDHA1 HEL-S-32 MITOCHONDRIAL LONG CHAIN FATTY ACID BETA OXIDATION%WIKIPATHWAYS_20260710%WP368%HOMO SAPIENS Mitochondrial long chain fatty acid beta oxidation PECR ACADVL CPT1A ACSL1 CPT2 FACL4 ACSL3 ACSF2 SLC25A20 ACADL EHHADH ACADM ACADS KININ KALLIKREIN PATHWAY%WIKIPATHWAYS_20260710%WP5089%HOMO SAPIENS Kinin Kallikrein pathway KNG1 CPN1 BDKRB2 BDKRB1 SERPING1 KLKB1 NUCLEAR RECEPTORS IN LIPID METABOLISM AND TOXICITY%WIKIPATHWAYS_20260710%WP299%HOMO SAPIENS Nuclear receptors in lipid metabolism and toxicity CYP2E1 CYP24A1 NR1B3 ABCA1 ABCB1 NR1i2 RARA RARB CYP27B1 CYP2B6 ABCC3 ABCG5 ABCC2 PPARG ABCB4 NR1I3 NR1i1 CYP4A11 NR1H4 ABCB11 CYP3A4 NR1H3 CYP7A1 CYP26A1 CYP2C9 NR1C2 CYP1A2 ABCG1 ABCD2 NR1C1 ABCD3 CYP8B1 HYPOTHESIZED PATHWAYS IN PATHOGENESIS OF CARDIOVASCULAR DISEASE%WIKIPATHWAYS_20260710%WP3668%HOMO SAPIENS Hypothesized pathways in pathogenesis of cardiovascular disease MAPK8 TGFBR1 TGFBR2 TGFBR3 MAPK3 AGTR1 ENG LTBP1 RUNX2 SMAD2 SHC1 SMAD4 MAPK14 FBN2 FBN3 ANGPT2 LTBP2 FBN1 POSTN CTGF FLNA NR2C2 MAPK1 MATRIX METALLOPROTEINASES%WIKIPATHWAYS_20260710%WP129%HOMO SAPIENS Matrix metalloproteinases TIMP1 TNF MMP3 MMP10 MMP7 MMP28 hEMMPRIN TIMP4 MMP14 MMP2 MMP23B MMP25 MMP21 MMP20 MMP24 MMP27 TCF20 TIMP3 MMP11 MMP26 MMP16 MMP15 MMP17 MMP19 MMP12 MMP9 TGF 1 SMAD2 3 SIGNALLING IN DECIDUAL NK CELLS AT THE FETAL MATERNAL INTERFACE%WIKIPATHWAYS_20260710%WP5637%HOMO SAPIENS TGF 1 SMAD2 3 signalling in decidual NK cells at the fetal maternal interface TGFBR1 ITGA1 TGFBR2 FOXP3 VEGFC CD14 SMAD2 TGFB1 ITGAE NCAM1 SMAD4 ANGPT1 SMURF2 IL2RA FCGR3A ANGPT2 KLRK1 KIR2DL4 CXCL8 IFNG CD9 NIFEDIPINE ACTIVITY%WIKIPATHWAYS_20260710%WP259%HOMO SAPIENS Nifedipine activity HEL-S-44 PCNA KDR BDKRB2 CYP3A4 PTK2B MAP2K1 MAPK1 CYTOKINES AND INFLAMMATORY RESPONSE%WIKIPATHWAYS_20260710%WP530%HOMO SAPIENS Cytokines and inflammatory response IL12B IL13 CXCL2 IL3 IL1A IFNB1 HLA-DRB1 IL10 TNF IL4 CSF2 IL5 TGFB1 IL2 IL1B CSF1 CSF3 IL6 IL7 PDGFA CXCL1 IFNG IL11 LNCRNA MEDIATED MECHANISMS OF THERAPEUTIC RESISTANCE%WIKIPATHWAYS_20260710%WP3672%HOMO SAPIENS lncRNA mediated mechanisms of therapeutic resistance CDKN1A BCL2L1 HIF1A ABCB1 ENDOMETRIAL CANCER%WIKIPATHWAYS_20260710%WP4155%HOMO SAPIENS Endometrial cancer MAPK3 GRB2 CTNNA1 CTNNA3 CTNNA2 CASP9 CDKN1A EGFR GADD45B GADD45G BAK1 FOS FGFR1 MYC FOXO3A AXIN1 DDB2 SOS2 POLK LEF1 BAX FGFR3 ERBB2 ARAF APC2 TCF7L2 EGF TCF7L1 CCND1 GSK3B AKT3 GADD45A BAD PTEN PIK3CD PIK3R3 FGF2 HRAS PIK3R1 APC MAP2K1 NRAS MAP2K2 PDPK1 HEL-S-28 FGFR2 SOS1 RAF1 PIK3CA AXIN2 PIK3R2 MAPK1 NOTCH SIGNALING%WIKIPATHWAYS_20260710%WP61%HOMO SAPIENS Notch signaling RING1 PSENEN FHL1 PSEN2 PSEN1 MAML2 HES6 ITCH LCK RBPJ NCOR2 SKP1 MTOR NCOR1 GSK3B HDAC2 EP300 HDAC1 MAML1 DTX1 SNW1 NOTCH3 NFKB1 NOTCH4 DLL4 PIK3R1 APH1B STAT3 NUMB JAG2 MAML3 DLL3 HEY2 NOTCH1 SAP30 FBXW7 SRC PIK3R2 NOTCH2 MAGEA1 CIRSR HES1 SPEN HES5 ADAM17 DISORDERS OF MITOCHONDRIAL HOMEOSTATIS DYNAMICS PROTEIN IMPORT AND QUALITY CONTROL%WIKIPATHWAYS_20260710%WP5504%HOMO SAPIENS Disorders of mitochondrial homeostatis dynamics protein import and quality control OPA3 GDAP1L1 MFN1 PMPCA MFN2 UBXN6 PAM16 OXA1L MARCHF5 PPA2 TMEM126A YME1L1 HSPD1 MICU1 AIFM1 CLPP SPG7 MFF PINK1 LONP1 TIMM50 MSTO1 DNAJC19 TIMM8A AGK GFER MICOS13 COQ5 COQ3 NPLOC4 XPNPEP3 SFXN4 RTN4IP1 HTRA2 MIPEP SACS STAT2 MCL1 PYCR2 VCP C1QBP TIMMDC1 USP9X TXN2 TXNRD2 UFD1L TRAK1 PLEK PMPCB PARK2 OPA1 ATAD3A PITRM1 UBXN1 CLPB KREBS CYCLE DISORDERS%WIKIPATHWAYS_20260710%WP4236%HOMO SAPIENS Krebs cycle disorders PDHX FH HEL-S-133P GPT HEL-S-281 PCK2 SUCLA2 DHTKD1 MPC1 SUCLG1 SUCLG2 NUCLEOTIDE EXCISION REPAIR IN XERODERMA PIGMENTOSUM %WIKIPATHWAYS_20260710%WP5114%HOMO SAPIENS Nucleotide excision repair in xeroderma pigmentosum DDB1 SLX4 POLK H2AC6 POLE4 CDK7 POLE2 RPA3 ERCC1 POLE3 ERCC2 MNAT1 CUL4B POLD3 POLD4 POLD2 RPA1 XAB2 SLX4IP RAD18 BRCA1 PCNA H4C9 UVSSA H3F3B HIST1H4L CHD1L CCNH CETN2 XPA XPC POLE GPS1 GTF2H2C_2 RFC3 RFC4 LIG1 RFC1 RFC2 GTF2H2 GTF2H3 GTF2H4 GTF2H5 DDB2 HMGN1 RBX1 CUL4A MITOCHONDRIAL IMMUNE RESPONSE TO SARS COV 2%WIKIPATHWAYS_20260710%WP5038%HOMO SAPIENS Mitochondrial immune response to SARS CoV 2 MITA NDUFAF1 PHB2 TBK1 IRF3 TICAM1 CGAS IKBKE TRAF3 NFKB1 NFKB2 ACE2 NDUFB9 ECSIT CTSL TMPRSS2 IRF7 AGTR1 TLR7 REN AGTR2 TLR3 IFIH1 TOMM70 ACAD9 NLRX1 MAVS TRAF6 RIGI CATALYTIC CYCLE OF MAMMALIAN FLAVIN CONTAINING MONOOXYGENASES FMOS %WIKIPATHWAYS_20260710%WP688%HOMO SAPIENS Catalytic cycle of mammalian flavin containing monooxygenases FMOs FMO4 FMO5 TELOMERE END PACKAGING AND NEURODEVELOPMENTAL DISORDERS%WIKIPATHWAYS_20260710%WP5567%HOMO SAPIENS Telomere end packaging and neurodevelopmental disorders H2AC6 H2BC17 H2BC12 H2BC13 H2AJ H2BC14 H2BC15 H2BC11 HIST1H2BE ACD TERF2IP TERF1 H2BC9 H2AZ1 H2AZ2 H4C9 H2BC8 HIST1H4L H2BC3 H2BC1 TERF2 H2AC20 H3-4 H2AX H2AC19 H2AB1 TPP1 H2AC14 H2BC26 H2BC12L H2BC21 HIST1H2AB SEROTONIN AND ANXIETY RELATED EVENTS%WIKIPATHWAYS_20260710%WP3944%HOMO SAPIENS Serotonin and anxiety related events HTR1A FOS PPP3CA ARC CRH PLCD4 PRKCB NLGN1 HTR2A PLEK SERINE METABOLISM%WIKIPATHWAYS_20260710%WP4688%HOMO SAPIENS Serine metabolism PSPH TYMS SHMT1 DHFR HEL-S-51e PSAT1 PHGDH VITAMIN A1 AND A5 X PATHWAYS%WIKIPATHWAYS_20260710%WP5397%HOMO SAPIENS Vitamin A1 and A5 X pathways RXRG NR1B3 RXRA RXRB RARA RARB BLOOD CLOTTING CASCADE%WIKIPATHWAYS_20260710%WP272%HOMO SAPIENS Blood clotting cascade F8 KLK1 HEL-S-78p F9 F11 VWF PLAT PLG FGA F2 F13B KLKB1 F10 SERPINB2 SERPINF2 F3 F5 F7 ACTIVATION OF NLRP3 INFLAMMASOME BY SARS COV 2%WIKIPATHWAYS_20260710%WP4876%HOMO SAPIENS Activation of NLRP3 inflammasome by SARS CoV 2 NLRP3 PYCARD RELA IL1B TRAF3 NFKB1 UTERINE NATURAL KILLER CELLS AND PROGESTERONE ESTROGEN AND CHORIONIC GONADOTROPIN%WIKIPATHWAYS_20260710%WP5569%HOMO SAPIENS Uterine natural killer cells and progesterone estrogen and chorionic gonadotropin VEGFA MAPK3 VCAM1 CXCL11 SELL CCL8 CCL4 CCL3 MRC1 GAB3 CX3CL1 NCR2 HLA-G PIBF1 MCL1 MAP2K4 ANGPT1 GATA2 IL2RG ANGPT2 MAPK11 JAK1 IL6 JAK3 NCR1 IFNG CD69 STAT5B NCR3 BCL2 IL3 CXCR4 MADCAM1 NR3A2 TNF PGR NR3C1 CXCR3 CXCL8 CCL2 ITGA4 CXCL12 IL10 IL4 CCL7 IL2RB KIR2DL4 IL15RA CCL5 RENIN ANGIOTENSIN ALDOSTERONE SYSTEM RAAS %WIKIPATHWAYS_20260710%WP4756%HOMO SAPIENS Renin angiotensin aldosterone system RAAS ITPR2 ATF4 CREB3 CREB3L3 CREB3L4 CYP11A1 CREB3L2 CREB5 CAMK4 PLCB2 CAMK2D CAMK1 CAMK1D CALM1 CYP21A2 CAMK1G ATF2 CAMK2A ATF1 CMA1 CTSG CREB1 CAMK2G STAR AGTR1 CALML6 HSD3B2 CALML3 ATF6B CALML4 REN AGTR2 CYP11B2 HSD3B1 MULTIPLE EPIPHYSEAL DYSPLASIA AND PSEUDOACHONDROPLASIA GENES%WIKIPATHWAYS_20260710%WP4789%HOMO SAPIENS Multiple epiphyseal dysplasia and pseudoachondroplasia genes COL9A1 COMP COL9A3 COL9A2 MATN1 MATN3 INFLAMMATORY RESPONSE PATHWAY%WIKIPATHWAYS_20260710%WP453%HOMO SAPIENS Inflammatory response pathway IL5RA COL1A1 COL1A2 LAMA5 THBS1 ZAP70 VTN LAMB2 LCK CD40LG CD40 LAMC1 TNFRSF1B COL3A1 LAMC2 IL4 IL5 THBS3 CD80 IL2RA IL2 IL2RB IL2RG TNFRSF1A LAMB1 IFNG VITAMIN B12 DISORDERS%WIKIPATHWAYS_20260710%WP4271%HOMO SAPIENS Vitamin B12 disorders AMN MMAA MTR MMACHC MMADHC CD320 CUBN TCN1 TCN2 MTRR CBLIF PTF1A RELATED REGULATORY PATHWAY%WIKIPATHWAYS_20260710%WP4147%HOMO SAPIENS PTF1A related regulatory pathway FGF10 KAT2B PROX1 PTF1A RBPJL PDX1 HES1 NKX6-1 NOTCH1 RBPJ MITOCHONDRIAL FATTY ACID SYNTHESIS PATHWAY%WIKIPATHWAYS_20260710%WP4317%HOMO SAPIENS Mitochondrial fatty acid synthesis pathway MECR OXSM HTD2 ACACA MCAT HSD17B12 AUTOPHAGY%WIKIPATHWAYS_20260710%WP4923%HOMO SAPIENS Autophagy PIK3R4 WIPI2 ATG14 ATG16L1 MLST8 AKT1S1 RPTOR MTOR PRKAA1 PRKAA2 PRKAG1 UVRAG PRKAG2 PRKAG3 DEPTOR DKFZp686F0183 RB1CC1 PRKAB2 ATG3 PRKAB1 DKFZp762B153 ATG12 ULK1 ATG9A AMBRA1 ATG101 SULFATASE AND AROMATASE PATHWAY%WIKIPATHWAYS_20260710%WP5368%HOMO SAPIENS Sulfatase and aromatase pathway HSD17B3 HSD17B1 HSD17B2 HSD3B1 SLCO4A1 SLCO1B1 SLCO4C1 SLCO1A2 NR3A2 SLCO2B1 SULT1E1 APOPTOSIS MODULATION BY HSP70%WIKIPATHWAYS_20260710%WP384%HOMO SAPIENS Apoptosis modulation by HSP70 MAPK10 AIFM1 CASP6 CASP9 MAP3K1 CASP8 APAF1 CASP3 CYCS RIPK1 FADD TNFRSF1A NFKB1 TNFSF6 CASP2 LET 7 INHIBITION OF ES CELL REPROGRAMMING%WIKIPATHWAYS_20260710%WP3299%HOMO SAPIENS let 7 inhibition of ES cell reprogramming KLF4 POU5F1 TRIM71 SOX2 MYC EGR1 T CELL RECEPTOR SIGNALING%WIKIPATHWAYS_20260710%WP69%HOMO SAPIENS T cell receptor signaling RIPK2 NFKBIA SH2B3 MAPK3 GRB2 FYN ZAP70 NCK1 NFATC2 LCK ATF2 MAPK8 FYB1 MAP3K14 PSTPIP1 CD3G PTK2B JUN CD3E VAV1 FOS PRKCQ MAPK14 LCP2 CBL LAT MAP3K7 NFATC1 TRAF6 PTPN11 GAB2 MAPK9 PLCG1 HEL-S-81p NFKB1 HRAS CD3D PIK3R1 VAV3 MAP2K1 GRAP2 MAP2K2 BCL10 CRKL PDPK1 CREB1 ICOS CHUK IKBKB CD8A MAP3K8 CARD11 IKBKG SOS1 RAF1 CRK SHC1 PIK3R2 MAP4K1 RELA ITK WAS PAK1 REL CDC42 MAPK1 MIR TARGETED GENES IN LYMPHOCYTES%WIKIPATHWAYS_20260710%WP2004%HOMO SAPIENS miR targeted genes in lymphocytes TUBA1A YWHAQ MTX1 PLAG1 AURKB PTPA MYO1E ABHD11 PPP3CA NCL HEL-S-273 NRP1 PLXND1 ARL10 RRP8 LOC541469 HOXA5 RFT1 SLC25A22 OTULINL GNPNAT1 SLC25A13 CEP72 VTI1B BRI3BP GFPT1 FERMT2 HOXD8 RCOR1 MEOX2 KIT VAMP3 TAF9B TRMT1 CYP1B1 LY6K GAS2L1 GEMIN2 MSI2 POLR2C ARID2 MPDU1 NPR3 UTP15 TMED10 RBM19 NF2 BACE1 POLD2 AKAP8 UBE2S LAMC1 SEC23A PDLIM7 ATAT1 TNFRSF10B COL4A2 GSTM4 BACH1 PISD KCNN4 SLC12A2 RNP24 GPAM MAP3K8 TCL1A RAB27B HEL-S-108 TPM3 SERPINE2 GOLGA7 GYS1 TPM1 SAC3D1 ATP6V1F MENT ADPGK PTRH1 LPL UNC93B1 SDCBP DCAF7 CYR61 AP2A1 HARS1 DDX5 GALNT1 IQGAP3 PTPRF NELFCD MOV10 LAMC2 IGF2BP1 ATG3 ARHG NOTCH1 C1QBP CYP51A1 SMAD1 DOCK5 ELMOD2 EHMT1 ASH2L TXN2 SNAP29 PRKCI FGF2 CDK6 ITGA2 USP1 RTN4 CSNK1D CDIPT RHOB MAPK7 NOTCH2 SSNA1 HEL-S-47e ELOVL5 SLC25A1 FADS2 FADS1 ANP32B DHX15 HEL-S-30 MRM1 RQCD1 PRPF40A PPP3R1 EIF4E VPS39 CHAF1A GPD2 TDG RDH10 SYNE1 GNA13 STRN ABCG2 AXL NEDD4 SYNE2 SPTLC1 PDE3A TGFBR2 CPNE8 VEZT TMEM41B PWP1 TNLG5A CHORDC1 CPOX SLC38A1 RAVER2 CIAO2A PSAT1 SEC62 CDK5RAP3 SFXN1 MBNL1 PPIF ATP6V0E1 HEL-S-303 IFRD1 FNDC3B CCND1 FNDC3A CARHSP1 WDR82 FAR1 TNFRSF10A MYB HACD3 UBE2J1 MRPL20 FBXW11 COMMD9 PNP GRPEL2 SMC1A ATP6V1C1 SNX6 NCEH1 TRAM1 GFM1 MAGT1 MYLIP MRC2 PANX1 COIL BDNF SERP1 TMED3 HEL-S-66 CTSC MRPS24 TMT1A AP3B1 SLC7A6 ARID1A CDCP1 RHEB ATP2A2 CSDE1 FRG1 FXR2 PXDN AMIGO2 TRIP13 NAPG PGRMC1 PPP1R7 EZH2 MPZL1 CACNA2D1 SPRYD4 TTC9C TMEM59 ARCN1 WDR11 TPPP3 ARF4 NFIA ANXA2 SNX15 HMOX1 LAMTOR3 LAMTOR5 TUSC2 LTN1 ARID4B ABHD10 POGLUT3 SH3BGRL3 PKN2 KPNA3 RARS1 VCAM1 DHX57 STX7 UBE4A PEDS1-UBE2V1 CDKAL1 MRPS33 RAB30 SYPL1 MARS2 PRIM1 GEMIN7 PPIB RAI14 PTMA SHOC2 CBFB POLA2 SLC1A4 ADIPOR2 CORO1C ANAPC1 CD164 BRPF3 HMGA1 SLC4A10 GNL3L CHMP2A HEL-S-26 SRPRB NT5C3A DKFZp761E1322 PTBP1 RB1 SNAP23 CEBPB DOCK7 CDKN1A TNFAIP2 EGFR LMNB2 TMEM109 PLK1 ACP2 SCYL1 HSDL1 RCN2 RBMS1 LUZP1 NUFIP2 MCL1 NXN UHRF1 HSD17B12 SUCLG2 DNAJB1 CAND1 CDKN1B TP53INP1 CDKN2A IRS1 SH3BP4 TBCA ZNF622 SLC25A24 GALNT7 MAPK14 SLC4A7 MAPK12 FMNL2 SLC25A32 BET1 TRPV6 E2F3 PPP2R5C NT5E BCL2 PPP5C POLE4 CAP1 PHC2 IGF2R TMEM43 P4HA2 SRSF10 PICALM SRSF9 CDKN1C ABCF2 CUL4B RAB23 TERT BCL6 TMED7 PURA CALCOCO2 CXCL12 MTRR AP3D1 ATG9A SPCS3 ADAR TYMS POM121 NARS1 RAB5C MTHFD2 CLDN1 DNMT3B BLADDER CANCER%WIKIPATHWAYS_20260710%WP2828%HOMO SAPIENS Bladder cancer UPK3A VEGFA FGFR3 HBEGF ERBB2 THBS1 ARAF EGF CCND1 CXCL8 RPS6KA5 HRAS PIK3R1 RB1 DAPK2 NRAS MAP2K1 CDKN1A MAP2K2 MDM2 EGFR CDK4 TYMP RAF1 RASSF1 CDKN2A SRC MMP2 PIK3R2 MYC MAPK1 MMP9 ERBB SIGNALING%WIKIPATHWAYS_20260710%WP673%HOMO SAPIENS ErbB signaling RPS6KB2 MAPK10 MAPK3 GRB2 FOXO1 NCK2 PRKCB NCK1 PRKCA MTOR RPS6KB1 NRG1 CAMK2D CAMK2A CDKN1A EGFR EREG MAPK8 BTC ERBB4 CAMK2G BCL2L11 NRG2 MAP2K4 CDKN1B JUN CBL MYC STAT5B SOS2 NRG4 HBEGF MAPK9 ERBB2 ARAF NRG3 EGF AREG CCND1 GSK3B AKT3 BAD PIK3CD PIK3R3 HRAS PIK3R1 ERBB3 MAP2K1 NRAS PLCG2 MAP2K2 MDM2 EIF4EBP1 CRKL PDPK1 SHC2 SOS1 RAF1 PIK3CA TGFA CRK SHC3 SHC1 SRC SHC4 PIK3R2 PAK6 PAK1 ABL2 PAK4 MAPK1 ANDROGEN RECEPTOR SIGNALING%WIKIPATHWAYS_20260710%WP138%HOMO SAPIENS Androgen receptor signaling KAT2B FOXO1 SUMO1 ZMIZ1 KAT5 HDAC1 ARHA RB1 NR2C2 STAT3 BRCA1 EGFR CREBBP UBE2I SMIM40 RUNX2 KDM1A TLE5 JUN RLN1 CARM1 FHL2 FLNA TGIF1 HEL-S-67p EFCAB6 HEL32 KAT7 NCOA1 ETV5 PIAS2 RAN TGFB1I1 ZNF318 LIMK2 FKBP4 RNF6 RNF4 BAG1 SMARCE1 PATZ1 NCOR2 NCOR1 SMAD4 CCND1 GSK3B EP300 RAC1 PTEN UBE3A PIK3R1 SIRT1 MDM2 CREB1 PIAS1 CCNE1 SP1 NR0B2 SRC RHOB PIK3R2 HEL-S-99n ROCK1 RELA ROCK2 PAK6 RAD9A SIN3A PSMC3IP CDC42 STUB1 HALLMARK OF CANCER METASTASIS AND EPITHELIAL TO MESENCHYMAL TRANSITION%WIKIPATHWAYS_20260710%WP5469%HOMO SAPIENS Hallmark of cancer metastasis and epithelial to mesenchymal transition TWIST1 SNAI1 SUZ12 ZEB2 SNAI2 KDM1A FOXC2 KLF8 TGFB1 GSC2 PRRX1 HDAC2 ELF3 HDAC1 EZH2 SIX1 TCF4 ELF5 SUV39H1 SIRT1 HAIR FOLLICLE DEVELOPMENT CYTODIFFERENTIATION STAGE 3 OF 3%WIKIPATHWAYS_20260710%WP2840%HOMO SAPIENS Hair follicle development cytodifferentiation stage 3 of 3 DSC2 MSX1 FOSB PERP RBPJ FZD1 DKK3 SOX2 IGFBP5 TCF4 GPRC5D EGFR GATA3 DKK1 NOTCH1 JUN TP63 S100A4 FOS GTPBP4 SFRP1 KLK6 GJB6 CD34 SMAD1 KRTAP8-1 WIF1 FOXQ1 IFNG NFATC1 FST ADAM17 IGF1 BMP6 CD200 LEF1 BMP4 RUNX3 CASP14 ATL1-beta EGR2 BMPR1A HR Nbla10317 NR3C1 HOXC12 KRTAP3-3 FOXE1 PHLDA1 SMAD4 KRTAP15-1 SPINK6 SPINK5 ADAMTS20 DSG1 DSG4 ZBTB16 DKK4 GAS1 GPR49 DLX3 SOSTDC1 KLK5 NFKB1 KLK4 LRIG1 KRTAP6-1 KRTAP2-4 ELANE GSDMA KITLG KLK13 KLK14 FOXN1 KRT19 CD133 SOX9 MSX2 TCF3 NOTCH2 CTGF PPAR ALPHA PATHWAY%WIKIPATHWAYS_20260710%WP2878%HOMO SAPIENS PPAR alpha pathway PLTP CDC2 CYP4A11 CDK4 CPT1A CPT2 RXRA NR1H3 CYP7A1 EHHADH APOC3 ACADM FABP1 DBI CCND1 UGT1A9 APOA2 KLK15 MYC NR1C1 APOA5 CYP8B1 SLC27A1 NAD METABOLISM%WIKIPATHWAYS_20260710%WP3644%HOMO SAPIENS NAD metabolism SIRT7 NRK NMNAT3 NMNAT2 SIRT4 NMNAT1 SIRT6 NAMPT SIRT5 SIRT1 SIRT3 NADK SIRT2 NT5E AMYOTROPHIC LATERAL SCLEROSIS ALS %WIKIPATHWAYS_20260710%WP2447%HOMO SAPIENS Amyotrophic lateral sclerosis ALS HEL-S-2 BCL2 HEL-S-44 BAX NEF3 BCL2L1 NEFH TNF NEFL RAB5A CASP9 CASP12 CASP3 APAF1 RAC1 BAD PPP3CA GPX1 PPP3CC MAP2K2 SMIM40 DERL1 MAP3K5 MAP2K6 MAPK14 CCS TNFRSF1A TOMM40 SLC1A2 ROLES OF CERAMIDES IN DEVELOPMENT OF INSULIN RESISTANCE%WIKIPATHWAYS_20260710%WP5181%HOMO SAPIENS Roles of ceramides in development of insulin resistance MAPK8 EIF2AK2 ACSL1 PPP2CA SLC2A4 TNF IRS1 CD36 RPS6KB1 TRAF1 TNFRSF1A INSR PDX1 INS MAFA ERN1 PIK3R1 PRKCZ PRKAG3 RETINOL METABOLISM%WIKIPATHWAYS_20260710%WP5188%HOMO SAPIENS Retinol metabolism ADH1A CYP2W1 DHRS4 PNPLA4 SDR16C5 RDH12 CYP3A7 AWAT2 LRAT BCO1 DHRS9 RPE65 CYP1A1 AOX1 CYP2A6 HEL-S-53e ERYTHROPOIESIS%WIKIPATHWAYS_20260710%WP5607%HOMO SAPIENS Erythropoiesis HBZ PTPRC HBG2 IL3 IL3RA HBG1 TF HBE1 HBA2 GATA1 HBB GDF11 HBD EPOR TFRC GATA2 KIT CD34 CD79A TNFSF6 EPO KITLG NEUROTRANSMITTER DISORDERS%WIKIPATHWAYS_20260710%WP4220%HOMO SAPIENS Neurotransmitter disorders PNMT TPH2 SLC18A2 TH DBH DDC TPH1 SLC6A3 MAOA TYROSINE METABOLISM AND RELATED DISORDERS%WIKIPATHWAYS_20260710%WP4506%HOMO SAPIENS Tyrosine metabolism and related disorders GSTZ1 HPD TYPE III INTERFERON SIGNALING%WIKIPATHWAYS_20260710%WP2113%HOMO SAPIENS Type III interferon signaling STAT1 TYK2 IRF9 IL10RB STAT2 IFNLR1 IFNL2 IFNL1 JAK1 IFNL3 FOXA2 PATHWAY%WIKIPATHWAYS_20260710%WP5066%HOMO SAPIENS FOXA2 pathway FOXA1 PPARGC1B APOB SLC27A5 FOXO1 SLCO1B1 MLXIPL IRS1 FOXA2 MTTP ACACA FASN ABCC3 INS GSTM2 ABCC2 LAMIN A PROCESSING PATHWAY%WIKIPATHWAYS_20260710%WP4299%HOMO SAPIENS Lamin A processing pathway ZMPSTE24 LMNA ICMT GPCRS CLASS B SECRETIN LIKE%WIKIPATHWAYS_20260710%WP334%HOMO SAPIENS GPCRs class B secretin like ADGRL1 ADGRE5 PTH1R GIPR GCGR SCTR GPR64 CALCR VIPR2 GHRHR ADGRL4 ADCYAP1R1 ADGRL2 CRHR2 ADGRL3 CALCRL GLP1R EICOSANOID METABOLISM VIA LIPOOXYGENASES LOX %WIKIPATHWAYS_20260710%WP4721%HOMO SAPIENS Eicosanoid metabolism via lipooxygenases LOX ALOX15 HPGD CYP4A11 CYP4F2 ACOX1 ALOX12 LTB4R FPR2 LTC4S CYP4F12 ALOX15B NR1C2 EHHADH ACOX3 TRPA1 KPG_011 TRPV1 HEL-S-298 CYP4A22 NR1C1 PTGR1 ALOX5 ENDOCHONDRAL OSSIFICATION WITH SKELETAL DYSPLASIAS%WIKIPATHWAYS_20260710%WP4808%HOMO SAPIENS Endochondral ossification with skeletal dysplasias VEGFA ACAN COL10A1 PTH1R DDR2 ALPL ENPP1 CAB39 CALM1 FGF18 IGF1R PLAT RUNX2 SCIN MGP SOX6 PTCH1 FGFR1 GLI3 STAT5B IGF1 BMP6 opn RUNX3 FGFR3 PTH MEF2C PTHLH BMPR1A CDKN1C ADAMTS4 ADAMTS5 NKX3-2 KIF3A CST5 STAT1 CHST11 BMP7 FGF2 GH1 GHR HMGCS1 SOX9 SOX5 TGFB1 THRA IGF2 TIMP3 FRZB COL2A1 MMP9 CELLULAR PROTEOSTASIS%WIKIPATHWAYS_20260710%WP4918%HOMO SAPIENS Cellular proteostasis PFDN1 PFDN2 PFDN4 PFDN5 PFDN6 VBP1 FUMARATE HYDRATASE DEFICIENT PAPILLARY RENAL CELL CARCINOMA%WIKIPATHWAYS_20260710%WP4241%HOMO SAPIENS Fumarate hydratase deficient papillary renal cell carcinoma CDKN1A VEGFA CREBBP FH SFPQ DVL2 EGLN1 ELOC EGLN2 TGFA BIRC7 TGFB1 VHL TFEB PRCC EP300 CADM2 HIF1A EGLN3 COL21A1 SETD2 RBX1 CTSK VITAMIN D METABOLISM%WIKIPATHWAYS_20260710%WP1531%HOMO SAPIENS Vitamin D metabolism CYP27A1 CYP2R1 NR1i1 DHCR7 PTH CYP24A1 GC RXRA RXRB CYP27B1 CAFFEINE IN NEURONS%WIKIPATHWAYS_20260710%WP5602%HOMO SAPIENS Caffeine in neurons ADORA2A ADRA1D ADRA1B ADRA1A APOE AND MIR 146 IN INFLAMMATION AND ATHEROSCLEROSIS%WIKIPATHWAYS_20260710%WP3926%HOMO SAPIENS ApoE and miR 146 in inflammation and atherosclerosis APOE RELA NFKB2 SPI1 IRAK1 TRAF6 TLR4 NON GENOMIC ACTIONS OF 1 25 DIHYDROXYVITAMIN D3%WIKIPATHWAYS_20260710%WP4341%HOMO SAPIENS Non genomic actions of 1 25 dihydroxyvitamin D3 MAPK3 PRKCB OAS2 PRKCA PLCB3 CD40 PLCB4 PLCB1 IFNA2 PLCB2 CAMK2D NOD2 IFNAR2 TLR4 CAMK2A MAPK8 NR1i1 CAMK2G IFNGR1 STAT2 IFNGR2 RXRB PRKCE JUN RXRG PRKCQ MAPK14 MAPK12 TNFRSF1A MAPK13 MAPK11 JAK1 IL6 IFNG TYK2 SP3 MAPK9 CYP24A1 DEFB4B TNF CD40LG CYP27B1 STAT1 CAMP MED1 PRKCH NFKB1 CXCL8 NFKB2 HRAS PRKCZ NRAS PLCG2 CCL2 ISG15 IKBKB SP1 RXRA TLR8 MAPK7 PLCE1 IFI27L2 RSAD2 RELB MAPK1 IL5 SIGNALING%WIKIPATHWAYS_20260710%WP127%HOMO SAPIENS IL5 signaling RPS6KB2 IL5RA MAPK3 GRB2 RPS6KA1 CSF2RB STAT1 GSK3B RPS6KB1 RPS6 BTK PIK3R1 MAP2K1 STAT3 MAP2K2 SOS1 RAF1 SPRED1 SYK JUN SHC1 PIK3R2 GSK3A IL2 LYN FOXO3A JAK1 STAT5B MAPK1 PTPN11 INITIATION OF TRANSCRIPTION AND TRANSLATION ELONGATION AT THE HIV 1 LTR%WIKIPATHWAYS_20260710%WP3414%HOMO SAPIENS Initiation of transcription and translation elongation at the HIV 1 LTR NFKBIA NFATC2 HDAC2 EP300 HDAC1 PPP3CA PPP3R1 PPP3R2 NFKB1 HDAC7 NFATC3 PPP3CC CREBBP NELFCD NFATC4 NELFA CDK9 HDAC3 NELFE SP1 NELFB SUPT5H RELA HDAC5 SUPT4H1 HEXIM1 NFATC1 HDAC8