FANCONI ANEMIA PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FANCONI ANEMIA PATHWAY Fanconi anemia pathway H2afx Atr Atm Blm Brca1 Rad17 Brca2 Fancd2 Rmi1 Stt3a Wdr48 Usp1 Atrip Topbp1 Btrc Ube2t Fanca Fancb Fancc Fancl Palb2 Fance Fancf RGD1306926 Rfc2 Rfc4 Rfc3 Rfc5 Mre11a Nbn Fbxw11 RGD1564719 Rad1 Hus1 Hes1 Rad50 Rpa2 Fan1 Rpa1 IL8-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL8-MEDIATED SIGNALING EVENTS IL8-mediated signaling events FOXA2 AND FOXA3 TRANSCRIPTION FACTOR NETWORKS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXA2 AND FOXA3 TRANSCRIPTION FACTOR NETWORKS FOXA2 and FOXA3 transcription factor networks Nkx2-1 Cpt1a Dlk1 Hnf4a Hmgcs1 Ttr Hadh Cpt1b Cpt1c Pck1 Ucp2 Afp Foxa1 Kcnj11 Cebpa Igfbp1 Bdh1 Foxa2 Foxa3 Pklr Abcc8 Tat Tfrc Sp1 Aldob Slc2a2 G6pc Acadm Hnf1a Akt1 Alb Acadvl F2 Ins2 Nf1 Creb1 IL5-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL5-MEDIATED SIGNALING EVENTS IL5-mediated signaling events Il5ra Csf2rb Lyn Pik3r1 Grb2 Pim1 Il5 Stat5b Sdcbp Stat5a Ptpn11 Cish SYNDECAN-4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-4-MEDIATED SIGNALING EVENTS Syndecan-4-mediated signaling events Mmp9 Nudt16l1 Adam12 Fgfr1 Rac1 Ccl5 Tfpi Cxcl12 F2 Mdk Fgf2 Itga5 Ptk2 Fgf6 Itgb1 Actn1 Dnm2 Prkcd Sdc4 Lama1 Prkca Fn1 Sdcbp Plg Gipc1 Rhoa Cxcr4 BCR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BCR SIGNALING PATHWAY BCR signaling pathway Lyn Grb2 Jun Shc1 Bcl10 Fos Ets1 Nfkb1 Raf1 Ikbkb Rac1 Cd79al Syk Mapk14 Ppp3ca Pten Ppp3cb Chuk Dok1 Mapk8 Csnk2a1 Mapk1 Cd72 Rela Vav2 Bcl2a1 Elk1 Cd79b Map2k1 Pdpk1 Fcgr2b Csk Camk2g Cd19 Cd22 Map3k7 Ptprc Blnk Akt1 Traf6 Rasa1 Ptpn6 Hras Map4k1 Dapp1 LOC100912399 Map3k1 Pik3r1 Nfkbia Sos1 Nfkbib AURORA B SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AURORA B SIGNALING Aurora B signaling Smc4 Smc2 Sgol1 Cdca8 Tacc1 Npm1 Kif2c Nsun2 Bub1 Klhl13 Cul3 Ncapd2 Stmn1 Incenp Sept1 Racgap1 Ndc80 Cenpa Kif23 Rasa1 Klhl9 Psma3 Pebp1 Ncapg Ppp1cc Mylk Kif20a Des Cbx5 Vim Rhoa Aurkb Aurka REGULATION OF TELOMERASE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF TELOMERASE Regulation of Telomerase Xrcc6 Esr1 Ifng Atm Tnks Blm Parp2 Acd E2f1 LOC100909750 Ccnd1 Hnrnpc Mxd1 Myc Ube3a Znfx1 Sin3a Max LOC100911576 Tinf2 Rps6kb1 Smg6 Jun Smg5 Tert Pinx1 Nr2f2 Abl1 Sap18 Egfr Cdkn1b Hdac1l Mre11a Nbn Irf1 RGD1561590 Wt1 Il2 Fos Mtor Tgfb1 Nfkb1 Rbbp7 LOC103692716 Terf2 Terf1 Smad3 Hdac2 Hdac1 Terf2ip Pot1 Mapk1 Sp1 Rad1 Hus1 Rad50 Akt1 Xrcc5 Ywhae N-CADHERIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%N-CADHERIN SIGNALING EVENTS N-cadherin signaling events Kif5b Ptpn11 Cttn Cnr1 Mapre1 Dagla Rock1 Jup Gap43 Fer Ptpn1 Gsn Cdh2 Gja1 Ctnna1 Daglb Dctn1 Lrp5 Fgfr1 Rac1 Plcg1 Ctnnd1 Pip5k1c Mapk8 Pik3r1 Camk2g Rhoa TRK RECEPTOR SIGNALING MEDIATED BY PI3K AND PLC-GAMMA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TRK RECEPTOR SIGNALING MEDIATED BY PI3K AND PLC-GAMMA Trk receptor signaling mediated by PI3K and PLC-gamma Ccnd1 Grb2 Shc1 Akt1 Plcg1 Bad Egr1 Ngf Src Sfn Camk4 Creb1 Kras Nras Ywhag Ywhah Prkcd Hras Gab1 Camk2a Ntrk1 Trpv1 Ywhaz Pdpk1 Ywhae Pik3r1 Sos1 Foxo3 Ywhab Trpc3 Stat5a Gsk3b IL6-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL6-MEDIATED SIGNALING EVENTS IL6-mediated signaling events Grb2 Myc Ptpn11 Jun Il6 Pias3 Mapk11 Pias1 Irf1 Lbp Jak1 Fos Bcl2l1 Junb Timp1 Akt1 A2m Rac1 Gab2 Map2k6 Mapk14 Crp Hsp90b1 Fgg Map2k4 Mitf Lmo4 Ptpre Vav1 Il6st Stat3 Foxo1 Stat1 Prkcd Socs3 Gab1 Hck Pik3r1 Sos1 MTOR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%MTOR SIGNALING PATHWAY mTOR signaling pathway Rragd Rraga Eef2 Eif4b Rragc Rb1cc1 Sgk1 Atg13 Btrc Ppargc1a Rps6kb1 Fbxw11 LOC100910121 Rrn3 Mtor Map2k2 Pld2 Raf1 Rptor Ikbkb Pld1 Bnip3 Ddit4 Yy1 RragB Pml Eif4ebp1 Sfn Rictor Srebf1 Ccne1 Kras Mapk1 Nras Cdk2 Ywhag Mapkap1 Poldip3 Ywhah Irs1 Ulk1 Eef2k Map2k1 Cycs Pdpk1 Ywhaz Ulk2 Akt1s1 Eif4a1 Prkca Tsc2 Pdcd4 Mlst8 Ywhab Tsc1 Prr5 Rps6ka1 Akt1 Hras Ywhae ROLE OF CALCINEURIN-DEPENDENT NFAT SIGNALING IN LYMPHOCYTES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ROLE OF CALCINEURIN-DEPENDENT NFAT SIGNALING IN LYMPHOCYTES Role of Calcineurin-dependent NFAT signaling in lymphocytes Crebbp Kpna2 Bcl2l1 Casp3 Akap5 Cabin1 Bcl2 Prkcz Mapk14 Fkbp8 Bad Sfn Xpo1 Camk4 Mef2d Mapk8 Csnk2a1 Ran Kpnb1 Ywhag Rcan2 Ywhah Prkcd Map3k8 Prkcb Nr4a1 LOC100912399 Prkch Ywhaz Map3k1 Fkbp1a Ywhae Prkaca Pim1 Prkca Nfatc2 Nfatc3 Prkcq Ywhab Csnk1a1 Chp1 Gsk3b Mapk9 SIGNALING EVENTS MEDIATED BY THE HEDGEHOG FAMILY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY THE HEDGEHOG FAMILY Signaling events mediated by the Hedgehog family Akt1 Shh Arrb2 Smo Lrp2 Tgfb2 Hhip Ptch1 Pik3r1 Dhh Lrpap1 Gli2 Cdon Boc Adrbk1 Ihh SYNDECAN-3-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-3-MEDIATED SIGNALING EVENTS Syndecan-3-mediated signaling events Fgfr3 Fgfr4 Pomc Fyn LOC102550316 Psenen Aph1b Agrp Psen1 Fgf23 LOC100911293 Src Ncan Sdc3 Fgf19 Mc4r Cttn Ncstn Ptn Egfr ATYPICAL NF-KAPPAB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATYPICAL NF-KAPPAB PATHWAY Atypical NF-kappaB pathway Rela Nfkb1 Ikbkb Syk Arrb2 Mapk14 Pik3r1 Nfkbia Lck Src Btrc ARF1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF1 PATHWAY Arf1 pathway Kdelr1 Asap1 Cd4 Pld2 Gosr2 Rac1 Cyth2 Ap2a1 Gbf1 Uso1 Arfgap1 Arfip2 Ap2m1 Gga3 Clta Cltb EGFR-DEPENDENT ENDOTHELIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EGFR-DEPENDENT ENDOTHELIN SIGNALING EVENTS EGFR-dependent Endothelin signaling events Mtor Hras Shc1 Ednra Edn1 Egfr Grb2 Sos1 ATR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATR SIGNALING PATHWAY ATR signaling pathway Ccna2 Atr Timeless LOC100911267 Mcm7 Plk1 Cdc25c Rad17 Brca2 Cdc25a Rad51 Fancd2 Stt3a Atrip Topbp1 Btrc Rfc2 Rfc4 Rfc3 Rfc5 Nbn Fbxw11 Rad1 Hus1 Rpa2 Rpa1 Cdk2 Ywhaz Ppp2r1a Ppp2ca Mcm2 Clspn Cdc6 Ywhab Mdm2 Cep164 Smarcal1 FOXA TRANSCRIPTION FACTOR NETWORKS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXA TRANSCRIPTION FACTOR NETWORKS FOXA transcription factor networks Foxa1 Foxa2 Foxa3 S1P3 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P3 PATHWAY S1P3 pathway Gna12 Gna11 Gnaq LOC100911280 Akt1 Rac1 Vegfa Flt1 S1pr3 Src Mapk1 Gna14 Gna13 Gnai3 Gna15 Pdgfb Gnao1 Pdgfrb Gnai2 Gnaz Gnai1 Akt3 Rhoa Cxcr4 SHP2 SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SHP2 SIGNALING SHP2 signaling Ifng Grb2 Ptpn11 Shc1 Il6 Egfr Il2 Map2k2 Raf1 Vegfa Ngf Kras Nras Gab1 Irs1 Ntrk1 Map2k1 Rhoa Gnai3 Pdgfb Pdgfrb Gnai1 Jak1 Frs2 Gab2 Lmo4 Il6st Sdc2 Ntf3 Stat1 Ntf4 Hras Tek Nos3 Ifngr1 Il2rg Bdnf Angpt1 Pik3r1 Prkaca Il2ra Sos1 Igf1r Arhgap35 Lck Frs3 Ntrk3 Ntrk2 Jak3 EPHA FORWARD SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHA FORWARD SIGNALING EPHA forward signaling Ngef Epha8 LOC100912512 Fyn Blk Epha4 Epha7 Pik3r6 Yes1 Lyn Vav3 Crk LOC100911248 Epha1 Epha2 Epha3 Rock1 Plcg1 Src Fgr Efna2 Pik3cg Vav2 Efna1 Arhgef15 Cbl Cdk5 Hck Crkl Lck Rhoa IL2 SIGNALING EVENTS MEDIATED BY PI3K%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL2 SIGNALING EVENTS MEDIATED BY PI3K IL2 signaling events mediated by PI3K E2f1 Grb2 Myc Ptpn11 Rps6kb1 Tert Shc1 Jak1 Il2 Bcl2l1 Mtor Nfkb1 Akt1 Sgms1 LOC103692716 Rac1 Eif3a Bcl2 Gab2 Prkcz Rps6 Ugcg Smpd1 LOC100911372 Rela Il2rg Il2ra Pik3r1 Sos1 Lck Foxo3 Jak3 P38 MAPK SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P38 MAPK SIGNALING PATHWAY p38 MAPK signaling pathway Atm Rac1 Map2k6 Mapk14 Gadd45g Gadd45b Tab2 Gadd45a Taok1 Txn1 Taok3 Map3k10 Traf2 Map3k3 Map3k4 Map3k6 Traf6 LOC100912399 Map3k1 Mapk11 Map3k7 VEGFR1 SPECIFIC SIGNALS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VEGFR1 SPECIFIC SIGNALS VEGFR1 specific signals LOC100911280 Akt1 LOC103692716 Vegfa Cd2ap Flt1 Plcg1 Nck1 Nrp2 Nrp1 Ptpn11 Mapk1 Rasa1 Prkcb Nos3 Cbl Pdpk1 Prkaca Shc2 Pik3r1 Pgf Prkca Hif1a REELIN SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REELIN SIGNALING PATHWAY Reelin signaling pathway Fyn LOC100911248 Lrpap1 Lrp8 Map2k7 Nck2 Vldlr Map1b Akt1 Arhgef2 Pafah1b1 Map3k11 Cdk5r1 Mapk8 Itga3 Dab1 Rap1a Itgb1 Cbl Cdk5 Crkl Reln Pik3r1 Grin2b Gsk3b IL3-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL3-MEDIATED SIGNALING EVENTS IL3-mediated signaling events Bcl2l1 Gab2 Hdac1 Grb2 Ptpn11 Cnksr1 Ywhag Il3ra Id1 Osm Srp9 Prkacb Shc1 Ywhaz Csf2rb Prkaca Pik3r1 Pim1 Stat5b Hdac1l Stat5a Cish ARF6 TRAFFICKING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF6 TRAFFICKING EVENTS Arf6 trafficking events Scamp2 Acap1 Ctnna1 Spag9 Exoc7 Klc1 Agtr1a Pld2 Itga11 Exoc6 Pld1 Ctnnd1 Itga8 Pip5k1c Exoc2 Cdh1 Itga10 Exoc5 Arf6 Ins2 Rala Exoc3 Itga5 Itga3 Itga6 Itga7 Itgb1 Dnm2 Bin1 Slc2a4 Adrb2 LOC100360745 Mapk8ip3 Vamp3 Tshr Itga4 Cltc Nme1 CALCIUM SIGNALING IN THE CD4+ TCR PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CALCIUM SIGNALING IN THE CD4+ TCR PATHWAY Calcium signaling in the CD4+ TCR pathway Fos Csf2 Il2 Fosl1 Junb Ifng Akap5 Ptgs2 Cabin1 Batf3 Cd40lg Il4 Faslg Pou2f1 Rcan2 Jun Fkbp1a Prkaca Il2ra Nfatc2 Nfatc3 Chp1 INTEGRIN FAMILY CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTEGRIN FAMILY CELL SURFACE INTERACTIONS Integrin family cell surface interactions Itga11 Itga8 Itga10 Itga3 Itga5 Itga6 Itga7 Itgb1 Itgb8 Itgb7 Itgal Itga2b Itgax Itgb6 Itgam Itga4 Itgb4 Itgb2 RAPID GLUCOCORTICOID SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RAPID GLUCOCORTICOID SIGNALING Rapid glucocorticoid signaling Gnal Crh Gnb1 Mapk14 Mapk11 Mapk8 Mapk9 GLYPICAN 3 NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN 3 NETWORK Glypican 3 network Shh Ptch1 Bmp4 Furin Fgf7 Mapk8 Mapk9 VEGFR3 SIGNALING IN LYMPHATIC ENDOTHELIUM%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VEGFR3 SIGNALING IN LYMPHATIC ENDOTHELIUM VEGFR3 signaling in lymphatic endothelium Akt1 Mapk14 Grb2 Map2k4 Crk Itga5 Creb1 Mapk1 Itgb1 Vegfc Flt4 Figf Col1a1 Col1a2 Shc1 Pik3r1 Sos1 Mapk11 Fn1 Itga4 Rps6ka1 GMCSF-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GMCSF-MEDIATED SIGNALING EVENTS GMCSF-mediated signaling events Csf2 Lyn Grb2 Ptpn11 Shc1 Fos Map2k2 Raf1 Ikbkb Gab2 Syk Kras Mapk1 Stat3 Nras Stat1 Hras Osm Prkacb Map2k1 Ywhaz Ccl12 Csf2rb Prkaca Pik3r1 Irf8 Pim1 Sos1 Stat5b Stat5a Cish PROTEOGLYCAN SYNDECAN-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PROTEOGLYCAN SYNDECAN-MEDIATED SIGNALING EVENTS Proteoglycan syndecan-mediated signaling events Sdc2 Sdc4 Sdc3 RAC1 SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RAC1 SIGNALING PATHWAY RAC1 signaling pathway Crk Jun Cybb Baiap2 Cyba Iqgap3 Plcb2 Actr2 Atf2 Brk1 Rac1 Abi2 Iqgap1 Abi1 Mapk14 Cdh1 Pak2 Cfl1 Pak1 Pip5k1b Limk1 Actr3 Mapk8 Bcar1 Noxa1 Arpc3 Arpc2 Arpc1b Ncf2 Arhgap5 Nckap1 Arhgdia Noxo1 Ncf1 Arpc4 Arpc5 Wasf1 Ctnna1 Map2k7 Map2k6 Map3k11 Pip5k1c Map2k4 Racgap1 Stat3 LOC100912399 Map3k1 Stat5a Mapk9 EPHA2 FORWARD SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHA2 FORWARD SIGNALING EPHA2 forward signaling Rac1 Grb2 Vav3 Pak1 Src Epha2 Ptk2 Bcar1 Vav2 Efna1 Cbl Shc1 Pik3r1 Tiam1 Arhgap35 Acp1 Rhoa NETRIN-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NETRIN-MEDIATED SIGNALING EVENTS Netrin-mediated signaling events Fyn Nck1 Yes1 Map2k2 Rac1 Map1b Plcg1 Unc5b Ntn1 Pak1 Src Unc5c Dcc Trio LOC100909609 Ptk2 Bcar1 Pitpna Mapk1 Dock1 Dapk1 Myo10 Camk2a Map2k1 Pik3r1 Rhoa ALPHA9 BETA1 INTEGRIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA9 BETA1 INTEGRIN SIGNALING EVENTS Alpha9 beta1 integrin signaling events Csf2 Adam12 Rac1 Vegfa Src Bcar1 Spp1 Itgb1 Pxn Adam15 Vegfc Tgm2 Figf Paox Adam8 F13a1 Kcnj15 Vcam1 Sat1 Adam2 Fn1 LOC497963 CANONICAL NF-KAPPAB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CANONICAL NF-KAPPAB PATHWAY Canonical NF-kappaB pathway Ripk2 Cyld Birc2 Nfkb1 Atm Ube2d3 Tnfrsf1a Ikbkb Nod2 Chuk Xpo1 Btrc Ran Traf6 Rela Bcl10 Erc1 Nfkbia Prkca VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL REPRESSION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL REPRESSION Validated targets of C-MYC transcriptional repression Dkk1 Slc11a1 Aldh9a1 Cdkn1a Brca1 Nfyc Nfyb Nfya Cflar Id2 Ccnd1 Gfi1 Ddit3 Smad2 Myc Zbtb17 Tmeff2 Lgals1 Clu Max Fth1 Dnmt3a Hdac3 Wnt5a Cdkn1b Hdac1l Ccl5 Smad3 Hdac1 Gadd45a Itga6 Itgb1 Tsc2 Foxo3 Cebpa Pdgfrb Itgb4 Sp1 Bcl2 Creb1 Erbb2 Ndrg1 Mxd4 Cdkn2b Ppp2r4 Col1a2 Tjp2 Ndrg2 Tbp Sfxn3 Spi1 Irf8 Gtf2h2 Hmgcs2 Dntt Sfrp1 Rbl1 Tmem126a NONGENOTROPIC ANDROGEN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NONGENOTROPIC ANDROGEN SIGNALING Nongenotropic Androgen signaling Gnai3 Gnao1 Gnai2 Gnaz Gnai1 Fos Plcb2 Map2k2 Raf1 Ar Rac1 Akt1 Gnb1 Plcg1 Plcb1 Src Gnrh1 Pelp1 Creb1 Ptk2 Plcb3 Shbg Mapk1 Hras Map2k1 Pik3r1 FAS (CD95) SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FAS (CD95) SIGNALING PATHWAY FAS (CD95) signaling pathway Birc2 Rfc1 Pik3cb Ripk1 Cflar Ezr Faslg Fas Birc3 Fadd Mapk11 Mapk10 Bid Casp8 Map2k7 Casp3 Akt1 Ikbkb Syk Map2k6 Mapk14 Smpd1 Chuk Src Mapk8 LOC100912399 Map3k1 Pdpk1 Pik3r1 Cltc Mapk9 ALPHA-SYNUCLEIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA-SYNUCLEIN SIGNALING Alpha-synuclein signaling Blk Fyn Yes1 Lyn Plcb2 Pld2 Pld1 Syk Bad Src Csnk2a1 Grk5 Fgr Ptk2b Prkcd Snca Tor1a Uchl1 Th Klk6 Hck Fkbp1a Ube2l3 Slc6a3 Maob Lck Park7 P63 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P63 TRANSCRIPTION FACTOR NETWORK p63 transcription factor network Tp63 DNA-PK PATHWAY IN NONHOMOLOGOUS END JOINING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DNA-PK PATHWAY IN NONHOMOLOGOUS END JOINING DNA-PK pathway in nonhomologous end joining Xrcc6 Dclre1c Polm Nhej1 Prokr1 Aptx Pnkp Poll Xrcc4 Lig4 Prkdc Aplf Xrcc5 Dntt SIGNALING EVENTS MEDIATED BY VEGFR1 AND VEGFR2%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY VEGFR1 AND VEGFR2 Signaling events mediated by VEGFR1 and VEGFR2 Ptpn2 Myof Cdh5 Akap1 Camkk2 Sh2d2a Grb2 Vcl Mapkapk2 Vtn Hsp90ab1 Ptpn11 Grb10 Mapk11 Fbxw11 Map2k2 LOC100911280 Raf1 LOC103692716 Vegfa Flt1 Iqgap1 Mapk14 Pak2 Src Ptk2 Mapk1 Ptk2b Dnm2 Prkcd Gab1 Cbl Map2k1 Pdpk1 Prkca Rhoa Fyn Nck1 Pxn Rock1 Ctnna1 Nck2 Akt1 Plcg1 Map2k6 Fes Ptprj Ptpn6 Prkcb Nos3 Pik3r1 Prkaca SIGNALING EVENTS MEDIATED BY HDAC CLASS III%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HDAC CLASS III Signaling events mediated by HDAC Class III Xrcc6 Crebbp Cdkn1a Mef2d Ppargc1a Foxo1 Tubb2a Foxo4 Acss2 Myod1 LOC100909443 Tp53 Bax Hoxa11 Acss1 Fhl2 Foxo3 Hdac4 Sirt3 Sirt2 ALPHA4 BETA1 INTEGRIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA4 BETA1 INTEGRIN SIGNALING EVENTS Alpha4 beta1 integrin signaling events Ptpra Thbs2 Amica1 Prkar1b Cd14 Igsf8 Cd81 Git1 Tln1 Crk Spp1 Pxn Vcam1 Adam28 Rac1 Abi1 Mdk Arf6 Src Bcar1 Ptk2 LOC100909609 Itgb1 Dock1 Ptk2b Prkacb Ywhaz Prkaca Fn1 Itga4 P75(NTR)-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P75(NTR)-MEDIATED SIGNALING p75(NTR)-mediated signaling Xiap Diablo Rhoc Rhob E2f1 Casp6 Prdm4 Myd88 Ngfr Mmp7 Rtn4r Zfp110 Apaf1 Shc1 Ikbkb Rac1 Bad Ngf Chuk Mapk8 Maged1 Omg Mageh1 App Casp9 Rtn4 Ntrk1 Arhgdia Ndn Cycs Prkci Adam17 Ngfrap1 LOC100912195 Sort1 Plg Sqstm1 Mag Rhoa Bcl2l11 Smpd2 Ripk2 Birc2 Psenen Aph1b Psen1 LOC100911293 Ncstn Birc3 Mapk10 Casp3 Akt1 Prkcz Furin Traf6 Ntf3 Ntf4 Prkacb Tp53 Bdnf Ywhae Pik3r1 Mapk9 WNT SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%WNT SIGNALING NETWORK Wnt signaling network Dkk1 Wnt7a Atp6ap2 Kremen2 Cthrc1 Fzd9 Fzd5 Fzd2 Igfbp4 Wif1 Rspo1 Ror2 Fzd1 Wnt7b Lrp6 Wnt3 Ryk Fzd6 Wnt1 Wnt3a Fzd4 Wnt5a Lrp5 TRK RECEPTOR SIGNALING MEDIATED BY THE MAPK PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TRK RECEPTOR SIGNALING MEDIATED BY THE MAPK PATHWAY Trk receptor signaling mediated by the MAPK pathway Ehd4 Rap1b Rps6ka5 Map2k5 Rit2 Mapkapk2 Srf Map3k2 Rit1 Mef2c Fos Raf1 Map2k6 Mapk14 Egr1 Cdk5r1 Creb1 Rap1a Kras Mapk1 Nras Ntf3 Prkcd Hras Elk1 Trpv1 Map2k1 Cdk5 Rps6ka1 SIGNALING EVENTS REGULATED BY RET TYROSINE KINASE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS REGULATED BY RET TYROSINE KINASE Signaling events regulated by Ret tyrosine kinase Nck1 Grb2 Crk Ptpn11 Grb10 Pxn Jun Shc1 Frs2 Rac1 Src Dok1 Mapk8 Creb1 Bcar1 Ptk2 Rap1a Mapk1 Ret Rasa1 Irs2 Irs1 Gab1 Hras Grb7 Shank3 Pdlim7 Dok4 Dok6 Prkaca Pik3r1 Prkca Gdnf Sos1 Rhoa ARF6 DOWNSTREAM PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF6 DOWNSTREAM PATHWAY Arf6 downstream pathway Pld2 Kalrn Rac1 Pld1 Rab11a Arf6 Tiam1 Rhoa Mapk1 Nme1 EFFECTS OF BOTULINUM TOXIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EFFECTS OF BOTULINUM TOXIN Effects of Botulinum toxin Vamp2 Unc13b Stxbp1 Rab3gap2 Syt1 Stx1a Chrna1 NECTIN ADHESION PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NECTIN ADHESION PATHWAY Nectin adhesion pathway Farp2 Pvrl1 F11r Pvrl2 Cldn1 Rac1 Pvrl3 Iqgap1 Ptprm Pip5k1c Cdh1 Rap1b Tln1 Crk Src Ptk2 Rap1a Vav2 Pdgfb Pdgfrb Pik3r1 Ctnna1 STABILIZATION AND EXPANSION OF THE E-CADHERIN ADHERENS JUNCTION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%STABILIZATION AND EXPANSION OF THE E-CADHERIN ADHERENS JUNCTION Stabilization and expansion of the E-cadherin adherens junction Pvrl2 Nck1 Git1 Vcl Epha2 Rock1 Diaph1 Mgat3 Vasp Lima1 Stx4 Aqp3 Egfr Zyx Ctnna1 Enah Myo6 Hgf Lpp Kifc3 Ctnnd1 Pip5k1c Abi1 Cdh1 Arf6 Exoc3 Actn1 Efna1 Nckap1 Igf1r Rhoa IGF1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IGF1 PATHWAY IGF1 pathway Grb2 Crk LOC100911248 Ptpn11 Grb10 Pxn Rps6kb1 Shc1 Ptpn1 Prkd1 Nck2 Raf1 Akt1 Prkcz Bad Ptk2 Bcar1 Irs2 Prkcd Hras Irs1 Ywhaz Pdpk1 Crkl Ywhae Pik3r1 Igf1r Sos1 SIGNALING EVENTS MEDIATED BY HEPATOCYTE GROWTH FACTOR RECEPTOR (C-MET)%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HEPATOCYTE GROWTH FACTOR RECEPTOR (C-MET) Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) Ptpn2 Grb2 Crk LOC100911248 Ptpn11 Jun Shc1 Hgf Mtor Ets1 Map2k2 Raf1 Rac1 Rptor Cdh1 Pak2 Bad Egr1 Pak1 Src Arf6 Eif4ebp1 Mapk8 Bcar1 Ptk2 Mapk1 Rin2 Gab1 Pard6a Sh3kbp1 Cbl F2rl2 Map2k1 Pak4 Pdpk1 Crkl Prkci Sh3gl2 Akt1s1 Snai1 Ranbp10 Muc20 Arhgef4 Apc Mlst8 Akt2 Rhoa Nck1 Rap1b Pxn Ptpn1 Ctnna1 Nck2 Akt1 Gab2 Plcg1 Prkcz Map2k4 Ptprj Rap1a Kpnb1 Hras LOC100912399 Map3k1 Pik3r1 Sos1 ATM PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATM PATHWAY ATM pathway H2afx Atm Blm Brca1 Rad17 Cdc25c Cdc25a Fancd2 LOC100909750 Fam175a Rbbp8 Kat5 Ube2n Uimc1 Trim28 Xrcc4 Tp53bp1 Smc1a Chek2 Ctbp1 Smc3 Abl1 Mre11a Bid Nbn Rad50 Terf2 Dclre1c Mdm2 Ywhab LPA RECEPTOR MEDIATED EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LPA RECEPTOR MEDIATED EVENTS LPA receptor mediated events Lyn Crk Jun Egfr Gna12 Mmp9 Fos Gna11 Prkd1 Nfkb1 Gnaq Pld2 Rac1 Src Bcar1 Ptk2 Rela Ptk2b Gab1 Prkcd Tiam1 Rhoa Gsk3b Pik3cb Gna14 Pxn Gna13 Gnai3 Gna15 Gnao1 Gnai2 Gnaz Gnai1 Lpar1 Casp3 Akt1 Plcg1 Gnb1 Adcy4 Adcy3 Adcy6 Adcy5 Lpar3 Lpar2 Plcb3 Lpar4 Slc9a3r2 Hras Mmp2 Adcy7 Adcy8 Hbegf Pik3r1 Nfkbia RXR AND RAR HETERODIMERIZATION WITH OTHER NUCLEAR RECEPTOR%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RXR AND RAR HETERODIMERIZATION WITH OTHER NUCLEAR RECEPTOR RXR and RAR heterodimerization with other nuclear receptor Tgfb1 Bcl2 Abca1 Ncor2 Rarg Thra Ncoa1 Thrb Srebf1 Rara Fam120b Rps6kb1 Ppara Ppard Pparg Rxrg Nr4a1 Nr1h3 Nr1h4 Med1 Rxra Nr1h2 Rxrb Vdr NOTCH SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NOTCH SIGNALING PATHWAY Notch signaling pathway Lnx1 Jag1 Notch1 Cdkn1a Dll3 Dner Dll4 Psenen Mfap5 Aph1b Mfap2 Il4 Ccnd1 Cul1 Ncor2 Dlk1 Rbbp8 Mib1 Cntn6 LOC100911293 Maml1 Myc Notch3 Notch2 Gata3 Btrc Notch4 Ctbp1 Ncstn Dnm1 Skp1 Skp2 Hdac1l Adam12 Rab11a Yy1 Hdac1 Furin Kdm1a Neurl1 Cntn1 Cbl Mark2 Eno1 Ptcra DIRECT P53 EFFECTORS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DIRECT P53 EFFECTORS Direct p53 effectors Steap3 Atf3 Tap1 Bcl6 Drosha Bcl2l2 E2f1 Bcl2l14 Triap1 Rrm2b Serpinb5 Cebpz Tp53bp2 Bnip3l Mlh1 Epha2 Pycard LOC100910137 Ddx5 Sesn1 Zfp385a Gdf15 Fdxr Bdkrb2 Dgcr8 Pcbp4 Pidd1 Rb1 Egfr Ctsd Nlrc4 Lif Igfbp3 Tyrp1 Hgf Taf9 Cx3cl1 Pou4f2 LOC502894 Tp53inp1 Cse1l Bak1 Pcna Tp73 Ddit4 Edn2 Hdac2 Vcan Gadd45a Tgfa Pml Prdm1 Casp1 Ccnk Ppm1j Prkab1 Plk3 Smarca4 Cd82 Tada2b Prmt1 Dusp1 Col18a1 LOC100911519 Tsc2 Serpine1 Apc Tp63 Carm1 Htt Dusp5 Irf5 Fas Bid Vdr Crebbp Bcl2 E2f3 Kat2a Ndrg1 Ccng1 Ppp1r13b Mmp2 Sh2d1a Msh2 Gpx1 Perp Pms2 Rnf144b Btg2 Rchy1 Hspa1b Hspa1a Dkk1 Cdkn1a Nfyc Nfyb Nfya Casp6 Apaf1 Jun Pten Sfn Bcl2a1 Mdm2 Spp1 Afp Foxa1 Sp1 Bcl2l1 Tp53 Bax BETA5 BETA6 BETA7 AND BETA8 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA5 BETA6 BETA7 AND BETA8 INTEGRIN CELL SURFACE INTERACTIONS Beta5 beta6 beta7 and beta8 integrin cell surface interactions Madcam1 Tgfbr1 Fbn1 Plau Itgb8 Itgb7 Cyr61 Vcam1 Itgb6 Fn1 Itga4 Vtn POSTTRANSLATIONAL REGULATION OF ADHERENS JUNCTION STABILITY AND DISSASSEMBLY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%POSTTRANSLATIONAL REGULATION OF ADHERENS JUNCTION STABILITY AND DISSASSEMBLY Posttranslational regulation of adherens junction stability and dissassembly Fyn LOC100909750 Mmp7 Rab7a Gna13 LOC100910807 Cbll1 Cables1 Jup Robo1 Snx1 Abl1 Ptpn1 Egfr Cdh2 Zbtb33 Ctnna1 Igf2 Slit1 Dsp Gna12 Crebbp Casp3 Rac1 Iqgap1 Ctnnd1 Cdh1 Arf6 Src Ret Dnm2 Rin2 Ptpn6 Hras Bdnf Gdnf Igf1r Tiam1 Ntrk2 Nme1 VALIDATED NUCLEAR ESTROGEN RECEPTOR ALPHA NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED NUCLEAR ESTROGEN RECEPTOR ALPHA NETWORK Validated nuclear estrogen receptor alpha network Esr1 Brca1 Ccnd1 Ndufv3 Xbp1 Ebag9 Myc Ube2m Hsf2 Dscam Esr2 Nrip1 Anp32a Nr0b1 Nedd8 Jun Ncoa7 Nr0b2 Atp5j Prdm15 Sra1 Phb2 Ctsd Mpg Uba3 Hdac1l Ncoa2 Prl C3 Pgr Abca3 Pou4f2 Apbb1 Safb Mta1 Axin2 Ap1b1 Pcna Ddx54 Sod1 Hdac1 Chuk Tff1 Set Calcoco1 Cd82 Col18a1 Ncor2 Ncoa1 Med1 Lmo4 Hdac4 Stat5a ERBB1 DOWNSTREAM SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB1 DOWNSTREAM SIGNALING ErbB1 downstream signaling Grb2 Sh2d2a Jun Baiap2 Egfr Fos Mtor Map2k2 Actr2 Raf1 Pld2 Atf2 Rac1 Brk1 Pld1 Iqgap1 Abi1 Bad Egr1 Src Rala Sfn Rictor Mapk8 Actr3 Mapk1 Kras Nras Arpc3 Mapkap1 Arpc2 Ywhag Arpc1b Ywhah Vav2 Prkcd Gab1 Elk1 Nckap1 F2rl2 Map2k1 Ywhaz Pdpk1 Ppp2r1a Dusp1 Ppp2ca Prkca Mlst8 Ywhab Arpc4 Arpc5 Pik3cb Rps6ka5 Map2k5 Srf Map3k2 Mef2c Bcl2l1 Akt1 Prkcz Rps6 Ralgds Mylpf Map2k4 Ppp5c LOC100911372 Ksr1 Ppp2r2a Usp6nl Creb1 Arf4 Stat3 Atf1 Rps6ka3 Eps8 Stat1 Hras Dusp6 LOC100911794 Slc9a1 Pebp1 LOC100912399 Smad1 Capn2 Map3k1 Ywhae Rin1 Pik3r1 Sos1 Mapk9 INTERNALIZATION OF ERBB1%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTERNALIZATION OF ERBB1 Internalization of ErbB1 Ube2d3 Pik3cb LOC100910792 Grb2 Tsg101 Cblb Ube2d1 Epn1 Spry2 Stambp LOC100909679 Chmp3 Shc1 Synj1 Itsn1 Usp8 Dnm1 Egfr Arhgef7 Lrig1 Zfyve28 Amph Raf1 Src Ptk2 Kras Nras Hras Sh3kbp1 Cbl Sh3gl2 Pik3r1 Sos1 VISUAL SIGNAL TRANSDUCTION: RODS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VISUAL SIGNAL TRANSDUCTION: RODS Visual signal transduction: Rods Rpe65 Pde6b Pde6a Gnb1 Cnga1 Gucy2f Lrat Sag Gnat1 Gucy2d Rgs9 Gnb5 Gngt1 Rgs9bp Rho Grk1 Guca1a Guca1b CDC42 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CDC42 SIGNALING EVENTS CDC42 signaling events Yes1 Rps6kb1 Jun Baiap2 Arhgef7 Enah Iqgap3 Tnk2 Limk2 Mtor Exoc7 Actr2 Sept2 Atf2 Raf1 Rac1 Pld1 Iqgap1 Mapk14 Cdh1 Pak2 Cfl1 Pak1 Cdc42bpa Src Arhgef6 Limk1 Actr3 Dlg1 Mapk8 Bcar1 Pax6 Mapk1 Hes5 Arpc3 Arpc2 Arpc1b Vav2 Pard6a Cbl F2rl2 Pak4 Arhgdia Tiam1 Apc Arpc4 Arpc5 Gsk3b Ctnna1 Map2k7 Map2k6 Prkcz Map3k11 Map2k4 Eps8 Hras LOC100912399 Map3k1 Pik3r1 Mapk9 REGULATION OF CYTOPLASMIC AND NUCLEAR SMAD2 3 SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF CYTOPLASMIC AND NUCLEAR SMAD2 3 SIGNALING Regulation of cytoplasmic and nuclear SMAD2 3 signaling Nup153 Ctdspl Kpnb1 Kpna2 Pias4 Ctdsp1 Ube2i LOC100912399 Smad3 Map3k1 Smad2 Mapk1 OSTEOPONTIN-MEDIATED EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%OSTEOPONTIN-MEDIATED EVENTS Osteopontin-mediated events Rock2 Map3k14 Vav3 Spp1 Jun Gsn Fos Mmp9 Nfkb1 Plau Rac1 Syk Chuk Mapk8 Bcar1 Mapk1 Rela Ptk2b Mmp2 LOC100912399 Map3k1 Ilk Nfkbia Pik3r1 Cd44 Rhoa NOTCH-MEDIATED HES HEY NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NOTCH-MEDIATED HES HEY NETWORK Notch-mediated HES HEY network Hey1 Twist1 Notch1 Parp1 Ptf1a Gaa E2f1 Hey2 Gata1 Rbbp8 LOC100911167 Ncor2 Arnt Tle1 Maml1 Ncoa1 Ghr Camk2d Bglap Gata4 Ctbp1 Rb1 Cdkn1b Hif1a Hdac1l Crebbp Cd4 Hes1 Ar Yy1 Hdac1 Stat3 Kdm1a Myod1 Hes6 Ascl1 Runx2 Neurog3 INTEGRINS IN ANGIOGENESIS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTEGRINS IN ANGIOGENESIS Integrins in angiogenesis F11r Vav3 Vcl Vtn Ptpn11 Rps6kb1 Cdkn1b LOC103692716 Rac1 Vegfa Src Fgf2 Bcar1 Ptk2 Mapk1 Ptk2b Irs1 Cbl Ilk Fn1 Rhoa Tln1 Spp1 Pxn Rock1 Csf1r Col3a1 Pik3c2a Angptl3 Col6a1 Col6a2 Pi4kb Col4a5 Casp8 Col5a1 Col5a2 Col11a1 Col4a3 Tgfbr2 Col4a1 LOC100911572 Akt1 Csf1 Mfge8 Col11a2 Col1a1 Col1a2 Pik3r1 Igf1r ENDOTHELINS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ENDOTHELINS Endothelins Crk Pla2g4a Mmp1 Trpc6 Jun Ednrb Edn3 Cysltr2 Cysltr1 Ednra Edn1 Slc9a3 Gna12 Fos Plcb2 Gna11 Map2k2 Gnaq Raf1 Rac1 Mapk14 Edn2 Src Mapk8 Bcar1 Mapk1 Ptk2b Prkcd Map2k1 Prkca Rhoa Gna14 Gnai3 Gna15 Gnao1 Col3a1 Gnai2 Gnaz Gnai1 Gnal Akt1 Plcb1 Adcy4 Adcy3 Adcy6 Adcy5 Plcb3 Hras Prkcb Col1a2 Slc9a1 Adcy7 Adcy8 Prkch Prkcq CXCR4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CXCR4-MEDIATED SIGNALING EVENTS CXCR4-mediated signaling events Rhoc Rhob Blk Pik3r6 Lyn Yes1 Crk Ptpn11 Dnm1 Mmp9 Plcb2 Mtor Rac1 Cxcl12 Bad Cfl1 Pak1 Src Rictor Limk1 Ptk2 Bcar1 Cd3g Fgr Cd3e Mapkap1 Pik3cg Cd3d Ptk2b Ralb Grk6 Ubqln1 Stat2 Pdpk1 Cd247 Vps4a Vps4b Csk RT1-Da RT1-Db1 Rgs1 Mlst8 Arr3 Rhoa Ssh1 Ptprc Cxcr4 Fyn Pik3cb Arrb2 Rap1b Pxn Gna13 Gnai3 Gnao1 Gnai2 Gnaz Gnai1 Adrbk1 Cd4 Akt1 Gnb1 Prkcz Plcb1 Vav1 Plcb3 Stat3 Foxo1 Ptpn6 Stat1 Hck Pik3r1 Lck Stat5b Stat5a PDGFR-ALPHA SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PDGFR-ALPHA SIGNALING PATHWAY PDGFR-alpha signaling pathway Jak1 Fos Plcg1 Grb2 Shf Crk Cav3 LOC100911248 Srf Pdgfra Csnk2a1 Jun Elk1 Shc1 Crkl Pik3r1 Sos1 SIGNALING BY AURORA KINASES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING BY AURORA KINASES Signaling by Aurora kinases Aurkb Aurka REGULATION OF P38-ALPHA AND P38-BETA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF P38-ALPHA AND P38-BETA Regulation of p38-alpha and p38-beta Pak3 Blk Dusp16 Fyn Map3k12 Dusp10 Ripk1 Yes1 Lyn Mapk11 Rac1 Map2k6 Mapk14 Pak2 Pak1 Map2k4 Src Rala Map3k3 Traf6 Fgr Ralb Hck Dusp1 Lck PAR4-MEDIATED THROMBIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PAR4-MEDIATED THROMBIN SIGNALING EVENTS PAR4-mediated thrombin signaling events Gna14 Rock2 Plcb2 Gna13 Gna11 Gnaq Gna15 Rock1 Gnb1 F2rl2 F2 Rhoa BETA2 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA2 INTEGRIN CELL SURFACE INTERACTIONS Beta2 integrin cell surface interactions Thy1 F11r Plau Cyr61 Cd40lg Proc Icam2 Fgg Fgb Fga Plat Jam3 Gp1ba Icam1 LOC103693683 Spon2 F10 Vcam1 Itgal Itgax Itgam C3 Itgb2 REGULATION OF NUCLEAR BETA CATENIN SIGNALING AND TARGET GENE TRANSCRIPTION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF NUCLEAR BETA CATENIN SIGNALING AND TARGET GENE TRANSCRIPTION Regulation of nuclear beta catenin signaling and target gene transcription Ctnnbip1 Dkk1 Lef1 Tcf7 Krt1 Tbl1x Sp5 Neurog1 Igf2bp1 Ccnd1 Tcf4 Id2 Cul1 Dkk4 Hbp1 Tle1 Myc Cby1 Myf5 Myog Btrc Tcf7l1 Dvl3 Ctbp1 Jun Tert Skp1 Hdac1l Ncoa2 Mmp9 Cacna1g Axin2 Ruvbl2 Hdac2 Cdh1 Hdac1 Vcan Sfn Camk4 Tbl1xr1 Ywhag Pitx2 Chd8 Ywhah Cdx4 Smarca4 Aes Mt-co2 Tnik Klf4 Ywhaz Zcchc12 Kcnip4 Tle2 Tle4 Apc Cdkn2a Ywhab Fgf4 Med12 T Ar Cyr61 Incenp Mitf Xpo1 Mmp2 Adcy7 Ywhae PDGFR-BETA SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PDGFR-BETA SIGNALING PATHWAY PDGFR-beta signaling pathway Blk Ptpn2 LOC100909750 Pik3r6 Yes1 Lyn Grb2 Myc Crk Grb10 Ptpn11 Abl1 Baiap2 Map2k2 Actr2 Rac1 Brk1 Iqgap1 Abi1 Pak1 Actr3 Bcar1 Fgr Arpc3 Arpc2 Pik3cg Arpc1b Dnm2 Prkcd Cbl Nckap1 Arhgdia Prkca Arpc4 Rhoa Arpc5 Pik3cb Rap1b Srf Cttn Arap1 Actn4 Jund Sphk1 Pdgfb Pin1 Slc9a3r1 LOC364561 Pdgfrb Lrp1 Ptpn1 Rab4a S1pr1 Sipa1 Myocd Mapk10 Eif2ak2 Tagln Plcg1 Slc9a3r2 Rasa1 Hras Ywhae Sos1 Arhgap35 Mapk9 Pla2g4a Jun Shc1 Fos Raf1 Pten Src Dok1 Sfn Mapk8 Mapk1 Kras Nras Ywhag Ywhah Vav2 Gab1 Elk1 Map2k1 Ywhaz Ppp2r1a Csk Ppp2ca Ywhab Fyn Nck1 Map2k7 Nck2 Map2k4 Ksr1 Usp6nl Ptprj Rap1a Stat3 Rps6ka3 Eps8 Stat1 Hck Pik3r1 Lck Stat5b Stat5a S1P4 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P4 PATHWAY S1P4 pathway Gna12 Gna13 S1pr4 Gnai3 S1pr5 Gnao1 Plcg1 Gnai2 Gnaz Gnai1 Rhoa Mapk1 GLYPICAN PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN PATHWAY Glypican pathway Gpc2 JNK SIGNALING IN THE CD4+ TCR PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%JNK SIGNALING IN THE CD4+ TCR PATHWAY JNK signaling in the CD4+ TCR pathway Lat Map2k4 Lcp2 Crk Dbnl LOC100911248 Mapk8 Map3k8 Jun Prkcb Map4k1 LOC100912399 Crkl Map3k1 Map3k7 DOWNSTREAM SIGNALING IN NÁVE CD8+ T CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DOWNSTREAM SIGNALING IN NÁVE CD8+ T CELLS Downstream signaling in na•ve CD8+ T cells Fosl1 Ifng Faslg Jun Il2 Fos Junb Map2k2 Raf1 Egr1 Mapk8 Kras Mapk1 Cd3g Nras Cd3e Stat1 Cd3d Hras Prkcb Elk1 Egr4 Tnfrsf9 Il2rg Cd8a Map2k1 Cd247 Ptpn7 Tnfrsf4 Cd8b Il2ra Prkca LOC100912356 Nfatc2 B2m Nfatc3 Prkcq Ifnar1 Mapk9 PLK1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLK1 SIGNALING EVENTS PLK1 signaling events Rock2 Ercc6l Cdk1 Spc24 Ect2 Plk1 Gorasp1 Cdc25c Cdc20 Cdc14b Kif2a Tpt1 Cenpu Bub1b Bora Stag2 Fbxo5 Btrc Kiz Rab1a Cdc25b Tubg1 Cenpe Sgol1 Ppp1cb Fzr1 Fbxw11 Bub1 Incenp Pak1 Ndc80 Ninl Ppp2r1a Wee1 Ppp2ca Kif20a Clspn Prc1 Tpx2 Rhoa Golga2 Ppp1r12a Aurka REGULATION OF CDC42 ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF CDC42 ACTIVITY Regulation of CDC42 activity Ngef Farp2 LOC100912512 Git1 Vav3 Itsn1 Dock6 Arhgef7 Mcf2l Dock11 Dnmbp Ralbp1 Spata13 Arhgef25 Plcg1 Itsn2 Arhgap1 Bcar3 Fgd1 Arhgap17 Arhgef6 Racgap1 Vav2 Arhgdia Apc Nme1 BETA1 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA1 INTEGRIN CELL SURFACE INTERACTIONS Beta1 integrin cell surface interactions Vtn Itga11 Vegfa Itga8 Itga10 Mdk Itga5 Itga6 Itga7 Itgb1 Lama1 Col18a1 Fn1 Itga4 Thbs2 Lamb2 Cd14 Nid1 Igsf8 Cd81 Lama4 Cspg4 Spp1 Tgm2 F13a1 Col3a1 Vcam1 Col6a1 Col6a2 Col4a5 Col5a1 Col5a2 Col11a1 Col4a3 Fbn1 Col4a1 Plau LOC100911572 Col11a2 Fgg Fgb Fga Itga3 Col1a1 Col1a2 Lamb3 Lamb1 Lamc1 Lamc2 FC-EPSILON RECEPTOR I SIGNALING IN MAST CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FC-EPSILON RECEPTOR I SIGNALING IN MAST CELLS Fc-epsilon receptor I signaling in mast cells Lyn Grb2 Cblb Ptpn11 Pla2g4a Jun Shc1 Fos Map2k2 Nfkb1 Pld2 Raf1 Ikbkb Syk Pak2 Chuk Dok1 Mapk8 Ptk2 Mapk1 Rela Cbl Map2k1 Dusp1 Fcgr2b Fyn Lat Ptpn13 Lcp2 Fcer1a Ppap2a Pxn Wipf1 Sphk1 Hcls1 Itk Lat2 Pla2g1b Fer S1pr1 Map2k7 Akt1 Gab2 Plcg1 Map2k4 Vav1 Rasa1 Hras Prkcb LOC100912399 Map3k1 Pik3r1 Sos1 Nfatc2 NONCANONICAL WNT SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NONCANONICAL WNT SIGNALING PATHWAY Noncanonical Wnt signaling pathway Arrb2 Tab2 Yes1 Dvl3 Pparg Rock1 Wnt5a Mapk10 Cthrc1 Rac1 Prkcz Fzd5 Fzd2 Mapk8 Ror2 Chd7 Flna Nlk Camk2a Fzd6 Dvl1 Daam1 Nfatc2 Csnk1a1 Map3k7 Rhoa Mapk9 CXCR3-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CXCR3-MEDIATED SIGNALING EVENTS CXCR3-mediated signaling events Pik3cb Gnai3 Gnao1 Gnai2 Gnaz Dnm1 Gnai1 Mapk11 Arrb1 Mtor Cxcl11 Map2k2 Cxcr3 Raf1 Cxcl10 Cxcl9 Akt1 Pf4 Gnb1 Map2k6 Mapk14 Src Rictor Cxcl13 Ccl11 Kras Mapk1 Nras Mapkap1 Hras Map2k1 Pdpk1 Pik3r1 Mlst8 NEUROTROPHIC FACTOR-MEDIATED TRK RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NEUROTROPHIC FACTOR-MEDIATED TRK RECEPTOR SIGNALING Neurotrophic factor-mediated Trk receptor signaling LOC100909750 Ccnd1 Grb2 Crk Ngfr LOC100911248 Ptpn11 Shc1 Abl1 Dnm1 Mcf2l Rac1 Ngf Kras Mapk1 Maged1 Nras Gab1 Ntrk1 Map2k1 Crkl Prkci Tiam1 Sqstm1 Gipc1 Rhoa Ehd4 Rap1b Rit2 Rit1 Shc2 Rgs19 Dynlt1 Rhog Frs2 Faim Dnaja3 Shc3 Gab2 Plcg1 Prkcz Matk LOC100909609 Rap1a Stat3 Ntf3 Dock1 Rasa1 Ntf4 Hras Bdnf Pik3r1 Sos1 Frs3 Ntrk3 Ntrk2 AURORA C SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AURORA C SIGNALING Aurora C signaling Incenp Aurkb CELLULAR ROLES OF ANTHRAX TOXIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CELLULAR ROLES OF ANTHRAX TOXIN Cellular roles of Anthrax toxin Map2k7 Map2k2 Map2k6 Map2k1 Vcam1 Il1b Antxr1 Map2k4 Il18 Casp1 Mapk1 Pgr SIGNALING EVENTS MEDIATED BY TCPTP%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY TCPTP Signaling events mediated by TCPTP Atr Ptpn2 Pik3cb Grb2 Pdgfb Shc1 Pdgfrb Csf1r Ptpn1 Rab4a Egfr Pias1 Eif2ak2 Hgf Crebbp Jak1 Kpna2 Vegfa Csf1 Src Ins2 Stat3 Itgb1 Stat6 Kpnb1 Stat1 Lman1 Insr Gab1 Pik3r1 Sos1 Stat5b Stat5a Jak3 INSULIN-MEDIATED GLUCOSE TRANSPORT%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INSULIN-MEDIATED GLUCOSE TRANSPORT Insulin-mediated glucose transport Vamp2 Akt1 Prkcz Stxbp4 Ins2 Sfn Ppp1r3a Rhoq Gys1 Ywhag Ywhah Insr Slc2a4 Prkci Ywhaz Ppp1cc Stx4 Ywhae Akt2 Ywhab Gsk3b RAS SIGNALING IN THE CD4+ TCR PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RAS SIGNALING IN THE CD4+ TCR PATHWAY Ras signaling in the CD4+ TCR pathway Nras Fos Raf1 Map3k8 Hras Prkcb Elk1 Map2k1 Ptpn7 Prkca Mapk1 Kras COREGULATION OF ANDROGEN RECEPTOR ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%COREGULATION OF ANDROGEN RECEPTOR ACTIVITY Coregulation of Androgen receptor activity Xrcc6 Brca1 Tcf4 Ccnd1 Vav3 Ube3a Nrip1 Prkdc Pias3 Uba3 Pias1 Ncoa2 Ccnd3 Pa2g4 Cdk6 Pawr Fkbp4 Nkx3-1 Prdx1 Snurf Ncoa4 Ncoa6 Kdm3a Tmprss2 Hip1 Lats2 Tgfb1i1 Mak Pias4 Kdm1a Ptk2b Ctdsp1 Ube2i Carm1 Cdkn2a Zfp318 Srf Zmiz1 Svil Tgif1 Gsn Med1 Casp8 Ar Akt1 Pelp1 Rps6ka3 Xrcc5 Fhl2 VISUAL SIGNAL TRANSDUCTION: CONES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VISUAL SIGNAL TRANSDUCTION: CONES Visual signal transduction: Cones Rpe65 Gucy2f Lrat Gucy2d Rgs9 Gnb5 Cngb3 Rgs9bp Slc24a2 Grk1 Gngt2 Pde6c Guca1a Gnat2 Guca1b Pde6h Gnb3 Arr3 THROMBOXANE A2 RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%THROMBOXANE A2 RECEPTOR SIGNALING Thromboxane A2 receptor signaling Blk Ptgdr Tbxa2r Ptgir Pik3r6 Ptgdrl Sele Yes1 Lyn Dnm1 Egfr Mapk11 Gna12 Plcb2 Gna11 Gnaq Rac1 Rab11a Syk Mapk14 Src Fgr Pik3cg Prkcd Prkca Arr3 Rhoa Fyn Arrb2 Gnb5 Gna14 Gna13 Tgm2 Gna15 Rock1 Slc9a3r1 Vcam1 Gnai2 Adrbk1 Akt1 Gnb1 Prkcz Icam1 Prkcb Nos3 Hck Prkch Prkaca Lck Prkcq ALK2 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALK2 SIGNALING EVENTS ALK2 signaling events Smad1 Bmpr2 Fkbp1a Acvr1 Smad5 Bmp7 Amhr2 Amh A6B1 AND A6B4 INTEGRIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%A6B1 AND A6B4 INTEGRIN SIGNALING a6b1 and a6b4 Integrin signaling Lamb2 Lama4 Grb2 Rps6kb1 Rxrg Shc1 Egfr Rxra Itgb4 Rxrb Mst1r Erbb3 Il1a Col17a1 Pmp22 Akt1 Rac1 Mst1 Cdh1 Sfn Itga6 Itgb1 Erbb2 Ywhag Ywhah Hras Ywhaz Lamb3 Ywhae Lamb1 Pik3r1 Lama1 Prkca Lamc1 Lamc2 Ywhab P38 SIGNALING MEDIATED BY MAPKAP KINASES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P38 SIGNALING MEDIATED BY MAPKAP KINASES p38 signaling mediated by MAPKAP kinases Raf1 Mapk14 Hspb1 Lsp1 Sfn Mapkapk3 Mapkapk2 Etv1 Srf Creb1 Cdc25b Ywhag Ywhah Th Ywhaz Ywhae Tsc2 Mapk11 Ywhab POLO-LIKE KINASE SIGNALING EVENTS IN THE CELL CYCLE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%POLO-LIKE KINASE SIGNALING EVENTS IN THE CELL CYCLE Polo-like kinase signaling events in the cell cycle Plk2 Plk3 Plk4 Plk1 IL4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL4-MEDIATED SIGNALING EVENTS IL4-mediated signaling events Bcl6 Grb2 Il5 Rps6kb1 Shc1 Mtor Ets1 Fcer2 Socs1 Mapk14 Irs2 Irs1 Cbl Cd40lg Il4 Il13ra2 Selp Parp14 Il13ra1 Arg1 Pigr Retnlg Tff3 Il10 Alox15 Oprm1 Lta Hmga1 Mybl1 LOC100360218 Ccl17 Egr2 aicda Socs5 Sp1 Il4r Dok2 Jak1 Bcl2l1 Thy1 Akt1 Fes Ccl11 Stat6 Ptpn6 Socs3 Col1a1 Col1a2 Il2rg Pik3r1 Spi1 Stat5b Stat5a Jak3 EPHRINB-EPHB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRINB-EPHB PATHWAY EphrinB-EPHB pathway Efnb1 Efnb2 Ephb3 Ephb1 Ephb2 TGF-BETA RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TGF-BETA RECEPTOR SIGNALING TGF-beta receptor signaling Tgfb3 Xiap Dab2 Zfyve16 Smad7 Wwp1 Bambi Dact2 Zfyve9 Arrb2 Smurf1 Tab2 Tgfbr3 Grb2 Dynlrb1 Daxx Smad2 Ppp1r15a Ctgf Ppp1ca Strap Rps6kb1 Sptbn1 Ppp2cb Shc1 Eif2a Tgfbr1 Tgfbr2 Tgfb1 Smad3 Pml Ppp2r2a Pard6a Camk2a Pdpk1 Fkbp1a Ppp2ca Ywhae Sos1 Map3k7 SIGNALING MEDIATED BY P38-ALPHA AND P38-BETA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING MEDIATED BY P38-ALPHA AND P38-BETA Signaling mediated by p38-alpha and p38-beta Esr1 Ptgs2 Ddit3 Hbp1 Rps6ka5 Mapkapk2 Ppargc1a Pla2g4a Jun Mef2c Usf1 Krt8 Atf6 Mapk11 Mknk1 LOC497963 Elk4 Atf2 Mapk14 Hspb1 Mitf Eif4ebp1 Mapkapk3 Creb1 Atf1 Slc9a1 Tp53 Mapkapk5 VALIDATED TRANSCRIPTIONAL TARGETS OF AP1 FAMILY MEMBERS FRA1 AND FRA2%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TRANSCRIPTIONAL TARGETS OF AP1 FAMILY MEMBERS FRA1 AND FRA2 Validated transcriptional targets of AP1 family members Fra1 and Fra2 Ccna2 Fosl1 Ccnd1 Bglap Mmp1 Jund Jun Il6 Gja1 Lif Itgb4 Sp1 Mmp9 Junb Plau Thbd Dcn Atf4 Nos3 Mmp2 Hmox1 Col1a2 Dmtf1 Mgp Txlng Ccl12 Nfatc2 Nfatc3 Cdkn2a SYNDECAN-1-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-1-MEDIATED SIGNALING EVENTS Syndecan-1-mediated signaling events Fgfr3 Fgfr4 Fgf23 Mmp7 Fgf19 Mmp1 Col3a1 Col6a1 Col6a2 Col4a5 Col5a1 Hgf Col5a2 Col11a1 Mmp9 Col4a3 Tgfb1 Col4a1 LOC100911572 Ccl5 Col11a2 Ppib Bsg Hpse Mapk1 Col1a1 Col1a2 Prkaca Sdcbp IFN-GAMMA PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IFN-GAMMA PATHWAY IFN-gamma pathway Ifng Smad7 Ptpn2 Rap1b LOC100911248 Camk2d Ptpn11 Pias1 Irf1 Crebbp Jak1 Mtor Ptges2 Irf9 Akt1 Socs1 Map3k11 Casp1 Rap1a Mapk1 Stat3 Stat1 Dapk1 Pias4 Prkcd Camk2a Cbl Ifngr1 LOC100912399 Map2k1 Map3k1 Crkl Il1b Pik3r1 Camk2g SYNDECAN-2-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-2-MEDIATED SIGNALING EVENTS Syndecan-2-mediated signaling events Fgfr3 Csf2 Fgfr4 Ezr Fgf23 Fgf19 Epb4.1 Trappc4 Cav2 Tgfb1 Casp3 Src Nf1 Mapk8 Mapk1 Ephb2 Itgb1 Sdc2 Rasa1 Prkcd Hras Mmp2 Bax Prkaca Lama1 Fn1 Sdcbp Rhoa TCR SIGNALING IN NÁVE CD8+ T CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TCR SIGNALING IN NÁVE CD8+ T CELLS TCR signaling in na•ve CD8+ T cells Map3k14 Fyn Lat Cd80 Rassf5 Grb2 Lcp2 Cd28 Stim1 Zap70 Rasgrp2 Rasgrp1 Orai1 Shc1 Trpv6 Bcl10 Cd86 Akt1 Ikbkb Plcg1 Chuk Vav1 Rap1a Kras Cd3g Traf6 Nras Cd3e Cd3d Ptpn6 Hras Map3k8 Prkcb Cbl Cd8a Cd247 Pdpk1 Csk Cd8b Prkca Sos1 B2m Lck Prkcq Ptprc TRAIL SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TRAIL SIGNALING PATHWAY TRAIL signaling pathway Tradd Tnfsf10 Dap3 Ikbkb Pik3cb Ripk1 Cflar Smpd1 Map2k4 Chuk Traf2 Mapk8 Mapk1 LOC100912399 Map3k1 Pik3r1 Fadd Casp8 VALIDATED NUCLEAR ESTROGEN RECEPTOR BETA NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED NUCLEAR ESTROGEN RECEPTOR BETA NETWORK Validated nuclear estrogen receptor beta network Ddx54 Ube2m Ncoa1 Esr2 Nr0b1 Nedd8 Smarca4 Nr0b2 Uba3 Ncoa2 Smarcb1 C3 Smarce1 Zfp709 SUMOYLATION BY RANBP2 REGULATES TRANSCRIPTIONAL REPRESSION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SUMOYLATION BY RANBP2 REGULATES TRANSCRIPTIONAL REPRESSION Sumoylation by RanBP2 regulates transcriptional repression Ran Ube2i Pias2 Hdac1 Ranbp2 Pias1 Hdac1l Hdac4 Xpo1 Mdm2 CASPASE CASCADE IN APOPTOSIS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CASPASE CASCADE IN APOPTOSIS Caspase Cascade in Apoptosis Xiap Diablo Parp1 Casp6 Apaf1 Krt18 Arhgdib Dffa Satb1 Acta1 Dffb Pidd1 Cradd Sptan1 Casp2 Cfl2 Tfap2a Gas2 Numa1 Madd Top1 Lmna Lmnb1 Lmnb2 Limk1 Traf2 Srebf1 Ptk2 App Casp9 Cycs LOC100911519 Tradd Tnfsf10 Tnfrsf1a Ripk1 Faslg Fas Gsn Birc3 Fadd Bid Casp8 Bcl2l1 Casp3 Akt1 Bcl2 LOC100912399 Map3k1 Bax Vim THROMBIN PROTEASE-ACTIVATED RECEPTOR (PAR) PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%THROMBIN PROTEASE-ACTIVATED RECEPTOR (PAR) PATHWAY Thrombin protease-activated receptor (PAR) pathway F2 IL12-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL12-MEDIATED SIGNALING EVENTS IL12-mediated signaling events Gzma Ripk2 Sphk2 Ifng Hlx Il12a Il4 Gadd45g Faslg Rab7a LOC497963 Il2 Fos Mtor Cd4 Nfkb1 Atf2 Socs1 Map2k6 Mapk14 Gadd45b Cd3g Stat3 Nfkb2 Cd3e Rela Ccr5 Stat6 Stat1 Cd3d Il12b Ccl4 Il18r1 Il12rb2 Il2rg Il1r1 Cd8a Cd247 Tbx21 Il1b Il2ra Cd8b RT1-Da Lck B2m RT1-Db1 Il18 Stat5a S1P2 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P2 PATHWAY S1P2 pathway Fos Gna12 Gna11 Gnaq Rac1 Mapk14 Cdh5 Pak1 Mapk8 Mapk1 Gna14 Gna13 Gnai3 Irs1 Gna15 Jun Elk1 Gnao1 Gnai2 Gnaz Gnai1 S1pr2 Rhoa SPHINGOSINE 1-PHOSPHATE (S1P) PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SPHINGOSINE 1-PHOSPHATE (S1P) PATHWAY Sphingosine 1-phosphate (S1P) pathway Gna12 Gna11 Sphk2 S1pr4 Gnaq S1pr5 S1pr3 Gna14 Gna13 Gnai3 Sphk1 Gna15 Gnao1 Gnai2 Gnaz Gnai1 S1pr1 S1pr2 LOC688708 Sgpl1 RHOA SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RHOA SIGNALING PATHWAY RhoA signaling pathway Rock2 Ezr Vcl Tln1 Srf Rdx Jun Rock1 Diaph1 Acta1 Slc9a3 Cdkn1b Fos Limk2 Atf2 Pld2 Pld1 Cyr61 Prkcz Map2k6 Pip5k1c Scai Cfl1 Pten Msn Mapk12 Map2k4 Pip5k1b Limk1 Mkl1 Cit Mapk8 Pkn2 Pkn1 Itgb1 Pard6a F2rl2 Slc9a1 Sh3gl2 Rhoa Ppp1r12a VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL ACTIVATION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL ACTIVATION Validated targets of C-MYC transcriptional activation Cdc25a Id2 Myc Kat5 Max Tert Nbn Taf9 Mmp9 Bcat1 Polr3d Hspa4 Mta1 Mtdh LOC103692716 Cdk4 Ruvbl2 Serpini1 Actl6a Smad3 Prdx3 Slc2a1 LOC100911431 Ruvbl1 Pdcd10 Shmt1 Myct1 Ubtf Eif4g1 Supt7l Hspd1 Eno1 Eif2s1 Snai1 Lin28b Eif4a1 Ireb2 Rpl11 Bmi1 Ddx18 Gpam LOC680559 Cad Nme1 Fosl1 Odc1 Hmga1 Tfrc Crebbp Npm1 E2f3 Kat2a Tp53 Bax Pim1 C-MYB TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%C-MYB TRANSCRIPTION FACTOR NETWORK C-MYB transcription factor network Lef1 Cdkn1a Ccnd1 Gata1 Casp6 LOC100911167 Myc Gata3 Sin3a Trim28 Pias3 Cdkn1b Ets1 Cdk6 Iqgap1 Ppp3ca Kras Nras Ube2i Ptcra Cdkn2a Map3k7 Maf LOC100363915 Slc25a3 Ppidl1 Anpep Ptgs2 Smarca2 Hipk2 Myf6 Cd34 Ccna1 Tab2 Atp2b1 H2afz Tom1 Kit Kitlg Ada Mcm4 Prtn3 Ets2 Cebpa Elane Snd1 Csf1r Mat2a Cbx4 Zfhx3 Birc3 Lect2 Yeats4 Car1 Mpo Sp1 Gstm7 LOC100911324 Crebbp Cd4 Hes1 Bcl2 Adora2b Rag2 Clta Mad1l1 Nlk Hras Col1a2 Myod1 Wnt1 Spi1 Pim1 CD40 CD40L SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CD40 CD40L SIGNALING CD40 CD40L signaling Map3k14 Birc2 Pik3cb Cd40lg Il4 Pik3r6 Cblb Myc Jun Birc3 Mapk11 Mapk10 Bcl2l1 Nfkb1 Fcamr Akt1 Tdp2 Traf3 Cd40 Mapk14 C4bpa Map2k4 Traf2 Mapk8 Traf6 Rela Pik3cg LOC100912399 Map3k1 Pik3r1 Nfkbia Stat5a Jak3 Mapk9 REGULATION OF RAS FAMILY ACTIVATION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RAS FAMILY ACTIVATION Regulation of Ras family activation Prkcz Rasgrp3 Rasgrp4 Grb2 Rasgrp2 Nf1 Rasgrp1 Lgals1 Kras Nras Rasa2 Rasal1 Rasa1 Rabgef1 Hras Plce1 Prkcb LOC100911794 Rras Syngap1 Lgals3 Rin1 Sos1 Prkca ALPHAE BETA7 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHAE BETA7 INTEGRIN CELL SURFACE INTERACTIONS AlphaE beta7 integrin cell surface interactions Itgb7 Cdh1 IL2 SIGNALING EVENTS MEDIATED BY STAT5%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL2 SIGNALING EVENTS MEDIATED BY STAT5 IL2 signaling events mediated by STAT5 Ccna2 Elf1 Foxp3 Il4 Faslg Grb2 Myc Ptpn11 Lta Shc1 Sp1 Jak1 Il2 Ccnd3 Bcl2l1 Cdk6 Bcl2 Gab2 Il2rg Il2ra Pik3r1 Sos1 Lck Stat5b Stat5a Jak3 FOXO FAMILY SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXO FAMILY SIGNALING FoxO family signaling Bcl6 Plk1 Faslg Sgk1 Zfand5 Fbxo32 Rbl2 Csnk1g2 Csnk1g1 Sod2 Csnk1d Csnk1g3 Skp2 Mapk10 Cdkn1b Cat Crebbp G6pc Akt1 Ikbkb Mst1 Gadd45a Usp7 Csnk1e Chuk Rala Sfn Xpo1 Mapk8 Cdk2 Ran Foxo1 Ywhag Ywhah Foxo4 Ralb Ywhaz Ywhae Foxo3 Ywhab Csnk1a1 Bcl2l11 Mapk9 SIGNALING EVENTS MEDIATED BY HDAC CLASS II%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HDAC CLASS II Signaling events mediated by HDAC Class II Esr1 Bcl6 Gata1 LOC100911167 Ncor2 Srf Mef2c Hdac3 Adrbk1 Hdac6 Ankra2 LOC100360129 LOC103692716 Hdac11 Gnb1 Hdac10 Gata2 Rfxank Xpo1 Camk4 Ran Tubb2a Ube2i Ywhae Ranbp2 LOC100910438 Hdac4 Ywhab P73 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P73 TRANSCRIPTION FACTOR NETWORK p73 transcription factor network Ccna2 Cdk1 LOC100911267 Cdkn1a Plk1 Brca2 Hey2 LOC100909750 Rad51 Gata1 Stt3a LOC100911167 Myc Kat5 Gdf15 Abl1 Rb1 Casp2 Mapk11 Wt1 Cdk6 Bak1 Tp73 Mapk14 Pml Sfn Cdk2 Plk3 Rela Bin1 Ntrk1 Serpine1 Foxo3 Tp63 Mdm2 Bcl2l11 Ccne2 Ndufs2 Pea15 Serpina1 Ube4b Rnf43 Hagh Il1rap Gramd4 Dedd Aen Nsg1 Ppap2a Clca2 Ada Afp Dcp1b Pin1 Pfdn5 Hsf1 LOC364561 Flot2 Fas Il4r Sp1 Jak1 Bub1 Prkacb Bax Rchy1 CIRCADIAN RHYTHM PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CIRCADIAN RHYTHM PATHWAY Circadian rhythm pathway Per1 Timeless Clock Atr Per2 Cry2 Nono Cry1 Stt3a Bhlhe40 Npas2 Csnk1e LOC100911602 Wdr5 Nr1d1 Arntl CANONICAL WNT SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CANONICAL WNT SIGNALING PATHWAY Canonical Wnt signaling pathway Cul3 Fzd5 Pip5k1b Dvl3 Lrp6 Ppp2r5a Pi4k2a Wnt3 Csnk1g1 Dvl1 Wnt3a Klhl12 Apc Nkd2 Ranbp3 Gsk3b Gsk3a BMP RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BMP RECEPTOR SIGNALING BMP receptor signaling Xiap Zfyve16 Smad7 Bambi Smurf1 Tab2 Fst Chrd Smad6 Ppp1r15a Chrdl1 Grem1 Ppp1ca Rgma Bmp6 Hfe2 Sostdc1 Bmp2 Nog Bmpr2 Smad5 Bmp7 Bmp4 Mapk1 Ctdspl Ctdsp1 Smad1 Map3k7 Gsk3b ALK1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALK1 PATHWAY ALK1 pathway Acvrl1 Fkbp1a Acvr1 GLUCOCORTICOID RECEPTOR REGULATORY NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLUCOCORTICOID RECEPTOR REGULATORY NETWORK Glucocorticoid receptor regulatory network Ifng Cdkn1a Sele Tsg101 Il5 Sgk1 Gata3 Bglap Mmp1 Jun Il6 Mapk11 Hdac1l Ncoa2 Irf1 Prl Il2 Fos Nfkb1 LOC103692716 Nr1i3 Fkbp4 Fkbp5 Il13 Suv420h1 Mapk14 Hdac2 Cga Pou1f1 Hdac1 Egr1 Smarcc2 Smarcc1 Krt14 Sfn Krt17 Mapk8 Csn2 Smarcd1 Mapk1 Rela Ywhah Smarca4 Cdk5 Mdm2 Gsk3b Csf2 Pomc Il4 Pou2f1 Ncoa1 Afp Mapk10 Crebbp Akt1 Fgg Ppp5c Cdk5r1 Creb1 Icam1 Stat1 Prkacb Nr4a1 Tp53 Tbx21 Tbp Bax Spi1 Prkaca Stat5b Stat5a Mapk9 VALIDATED TRANSCRIPTIONAL TARGETS OF TAP63 ISOFORMS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TRANSCRIPTIONAL TARGETS OF TAP63 ISOFORMS Validated transcriptional targets of TAp63 isoforms Jag1 Cdkn1a Wwp1 Plk1 Shh LOC100909750 Serpinb5 Hbp1 Aen Btrc Clca2 Ada Cables1 Gdf15 Fdxr Flot2 Smarcd3 Abl1 Fas Ogg1 Tfap2c Noc2l Egr2 Dicer1 Igfbp3 Dhrs3 Itgb4 Spata18 Sp1 Vdr Evpl Ikbkb Mfge8 Gadd45a Pml Chuk Itga3 Prkcd Perp Bax Cdkn2a Ssrp1 Tp63 Mdm2 Gpx2 Traf4 Nqo1 EPHRIN A REVERSE SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRIN A REVERSE SIGNALING Ephrin A reverse signaling Fyn REGULATION OF ANDROGEN RECEPTOR ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF ANDROGEN RECEPTOR ACTIVITY Regulation of Androgen receptor activity Appbp2 Hoxb13 Trim24 Senp1 Ehmt2 Kat7 Smarca2 Zmiz2 Pde9a Nr2c1 Nr2c2 Pou2f1 Spdef Kat5 Ncoa1 Nr0b1 Jun Cebpa Rxrg Hdac1l Ncoa2 Rxra Rxrb Crebbp Ar LOC103692716 Gata2 Map2k6 Mapk14 Hdac1 Egr1 Map2k4 Tmprss2 Src Smarcc1 Mapk8 Pkn1 Foxo1 Carm1 Dnaja1 Rchy1 Mdm2 Smarce1 Gsk3b BETA3 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA3 INTEGRIN CELL SURFACE INTERACTIONS Beta3 integrin cell surface interactions F11r Lama4 Vtn Spp1 Sphk1 Pdgfb Pdgfrb Itga2b Col4a5 Col4a3 Thy1 Fbn1 Tgfbr2 Plau Col4a1 Vegfa LOC100911572 Cyr61 Fgg Fgb Fga Col1a1 Col1a2 Sdc4 L1cam Ibsp Lamb1 Lamc1 Fn1 Cd47 EPHRINA-EPHA PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRINA-EPHA PATHWAY EphrinA-EPHA pathway Epha8 Epha4 Epha7 Epha2 Epha3 DEGRADATION OF BETA CATENIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DEGRADATION OF BETA CATENIN Degradation of beta catenin Axin2 Fzd5 Cul1 Csnk1e Btrc Dvl3 Lrp6 Wnt3 Dvl1 Wnt3a Csnk1d Skp1 Apc Csnk1a1 Gsk3b Gsk3a S1P1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P1 PATHWAY S1P1 pathway Plcb2 Rac1 Vegfa Ptgs2 Plcg1 Mapk1 Gnai3 Sphk1 Pdgfb Gnao1 Pdgfrb Gnai2 Gnaz Gnai1 S1pr1 LOC688708 Rhoa REGULATION OF RHOA ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RHOA ACTIVITY Regulation of RhoA activity Ngef LOC100912512 Ect2 Vav3 Arap1 Arhgdib Def6 Arhgef18 Arhgef11 Cdkn1b Net1 Mcf2l Farp1 Arhgef3 Arhgef5 Arhgap8 Arhgef25 Arhgap9 Arhgef2 Arhgef28 Ophn1 Abr Srgap1 Myo9b Trio Vav1 Vav2 Arhgef15 Arhgap5 Arhgdia Arhgap35 Rhoa AP-1 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AP-1 TRANSCRIPTION FACTOR NETWORK AP-1 transcription factor network Elf1 Esr1 Atf3 Cdk1 Ifng Penk Ccnd1 Cbfb Dmp1 Il5 Bag1 Myc Mafg Mt2A Agt Mmp1 Jun Nppa Fabp4 Nts Acta1 Il6 Edn1 Cdkn1b Il2 Mmp9 Fos Ets1 Tgfb1 Atf2 Gata2 Egr1 Pten Th Dusp1 Cdkn2a Bcl2l11 Maf Csf2 Fosl1 Il4 Jund Il10 Hif1a Gja1 Sp1 Junb Plau Timp1 Cyr61 Creb1 Col1a2 Dmtf1 Tp53 Ccl12 Nfatc2 Nfatc3 AURORA A SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AURORA A SIGNALING Aurora A signaling Brca1 Git1 Cdc25b Fzr1 Arhgef7 Tacc1 Akt1 Gadd45a Pak1 Cenpa Ran Rasa1 Tp53 Tacc3 Dlgap5 Nfkbia Prkaca Ckap5 Oaz1 Ajuba Ndel1 Tpx2 Mdm2 Cpeb1 Aurkb Ccnl2 Aurka Gsk3b INSULIN PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INSULIN PATHWAY Insulin Pathway Ptpra Nck1 Grb2 Crk Sgk1 Rhoq Ptpn11 Grb10 Rps6kb1 Shc1 Ptpn1 Exoc7 Nck2 Akt1 Exoc6 Prkcz Exoc2 Sh2b2 Sorbs1 Exoc5 Eif4ebp1 Ins2 Dok1 Exoc3 Rasa1 Insr Pard6a Hras Irs1 Cbl F2rl2 Grb14 Prkci Pdpk1 Pik3r1 Sos1 Foxo3 Akt2 RETINOIC ACID RECEPTORS-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RETINOIC ACID RECEPTORS-MEDIATED SIGNALING Retinoic acid receptors-mediated signaling Cdk1 Ncor2 Rarg Ncoa1 Nrip1 Rara Rxrg Hdac3 Ncoa2 Rxra Hdac1l Rxrb Vdr Crebbp Mnat1 Cdk7 Akt1 Mapk14 Hdac1 Mapk8 Rbp1 Ccnh Mapk1 Prkaca Prkca IL1-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL1-MEDIATED SIGNALING EVENTS IL1-mediated signaling events Tab2 Myd88 Il1rap Ube2n Tollip Il1r2 Ube2v1 Il1rn Jun Irak3 Irak4 LOC100912618 Ticam2 LOC100362142 Nfkb1 Il1a Ikbkb Map2k6 Prkcz Chuk Casp1 Map3k3 Mapk8 Traf6 Rela Il1r1 Prkci Erc1 Il1b Pik3r1 Sqstm1 Map3k7 LKB1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LKB1 SIGNALING EVENTS LKB1 signaling events Esr1 Ezr Stk11ip Mark4 Psen2 Map2 Myc Smarcd3 Ctsd Mtor LOC103692716 Rptor Sfn Creb1 Stradb Ywhag Cab39 Cdc37 Ywhah Stk11 Sik1 Brsk1 Mark2 Stk26 Ywhaz Strada Tp53 Akt1s1 Ywhae Prkaca Tsc2 Etv4 Mlst8 Ywhab Tsc1 Gsk3b GLYPICAN 2 NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN 2 NETWORK Glypican 2 network Gpc2 Mdk E2F TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E2F TRANSCRIPTION FACTOR NETWORK E2F transcription factor network Uxt Ccna2 Xrcc1 Cdk1 Ranbp1 Atm E2f6 Cdkn1a Brca1 Cdc25a E2f1 Rbbp8 Hbp1 Myc Topbp1 Apaf1 Trim28 Tyms Tfdp2 Rrm2 Rbl2 RGD1565297 Sult2a1 Ces1d Ces4a Ces5a Mybl2 Rb1 Ces2h Cdkn2c Cdkn1b Orc1 Dhfr Hdac1l E2f5 Mcm3 E2f7 Ccnd3 Tp73 Yy1 Hdac1 Ccne1 Cdk2 Serpine1 Cdkn2a Cdc6 Wasf1 Ccne2 Smarca2 Cebpa Sp1 Crebbp Plau Prmt5 Tfe3 E2f3 Kat2a Cbx5 Rbl1 HYPOXIC AND OXYGEN HOMEOSTASIS REGULATION OF HIF-1-ALPHA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HYPOXIC AND OXYGEN HOMEOSTASIS REGULATION OF HIF-1-ALPHA Hypoxic and oxygen homeostasis regulation of HIF-1-alpha LOC103692716 Arnt Os9 Tceb1 Egln2 Egln3 Vhl Hif3a Cul2 Hif1an Rbx1 Tp53 Hif1a Cdkn2a IL23-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL23-MEDIATED SIGNALING EVENTS IL23-mediated signaling events Ifng Il6 LOC497963 Mpo Il19 Il2 Il23r Nfkb1 Cd4 Il24 Alox12b Il17f Cxcl9 Cxcl3 Il17a Il23a Itga3 Stat3 Rela Cd3e Stat1 Il12b Socs3 Il18r1 Ccl12 Pik3r1 Il1b Nfkbia Il18 Stat5a EPO SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPO SIGNALING PATHWAY EPO signaling pathway Lyn Grb2 LOC100911248 Ptpn11 Shc1 Bcl2l1 Nfkb1 Bcl2 Plcg1 Mapk14 Tec Epor Mapk8 Epo Rap1a Irs2 Stat1 Ptpn6 Vav2 Socs3 Gab1 Hras Cbl Crkl Pik3r1 Sos1 Stat5b Stat5a HIF-1-ALPHA TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HIF-1-ALPHA TRANSCRIPTION FACTOR NETWORK HIF-1-alpha transcription factor network Id2 Arnt Pkm Pgm1 Pfkl Rora Jun Nt5e Tert Plin2 Bhlhe41 Car9 Edn1 Hk2 Ncoa2 Fos Ets1 Vegfa Abcg2 Bnip3 Pgk1 Gata2 Adm Smad3 Cxcl12 Cp Aldoa Fech Abcb1a Lep Slc2a1 Tf Epo Pfkfb3 Cited2 Egln3 Eno1 Serpine1 Cxcr4 Hnf4a Ncoa1 Tff3 Igfbp1 Hif1a LOC497963 Tfrc Sp1 Itgb2 Crebbp Npm1 Akt1 Furin Bhlhe40 Creb1 Ndrg1 Hmox1 LPA4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LPA4-MEDIATED SIGNALING EVENTS LPA4-mediated signaling events Gnal Adcy7 Adcy8 Adcy4 Prkaca Adcy3 Adcy6 Rps6ka5 Adcy5 Creb1 Lpar4 ARF6 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF6 SIGNALING EVENTS Arf6 signaling events Fbxo8 Lhcgr Acap2 Cyth3 Nck1 Gulp1 Kif13b Git1 Arrb2 Epha2 Pxn Gna14 Acap1 Gna15 Itga2b Egfr Hgf Arrb1 Gna11 Gnaq Agtr1a Cyth2 Arf6 Src Efna1 Adrb2 LOC100360745 Tshr NEPHRIN NEPH1 SIGNALING IN THE KIDNEY PODOCYTE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NEPHRIN NEPH1 SIGNALING IN THE KIDNEY PODOCYTE Nephrin Neph1 signaling in the kidney podocyte Fyn Cd2ap Pik3cb Nck1 Arrb2 Nphs2 Grb2 Kirrel Nphs1 Tjp1 Trpc6 Jun Mapk10 Nck2 Rac1 Akt1 Plcg1 Prkcz Bad Map2k4 Mapk8 Pard6a F2rl2 Prkci Pik3r1 Mapk9 PAR1-MEDIATED THROMBIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PAR1-MEDIATED THROMBIN SIGNALING EVENTS PAR1-mediated thrombin signaling events Rock2 Gna14 Gna13 Gnai3 Trpc6 Gna15 Rock1 Gnao1 Gnai2 Vasp Snx1 Gnaz Dnm1 Gnai1 Zyx Arrb1 Gna12 Gna11 Plcb2 Gnaq Gnb1 F2 Plcb1 Plcb3 Pkn1 Dnm2 Prkcd Prkcb Nos3 Snx2 F2rl2 Arhgdia F2r Pik3r1 Prkca Rhoa PRESENILIN ACTION IN NOTCH AND WNT SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PRESENILIN ACTION IN NOTCH AND WNT SIGNALING Presenilin action in Notch and Wnt signaling Dkk1 Notch1 Psenen Aph1b Ccnd1 Psen1 Myc LOC100911293 Tle1 Btrc Ctbp1 Ppard Jun Ncstn Hdac1l Fbxw11 Fos Crebbp Kremen2 Hnf1a Hdac1 Wif1 Fzd1 Csnk2a1 Mapk1 Lrp6 Nkd1 Dkk2 Nlk Aes Dvl1 Wnt1 Apc Map3k7 Csnk1a1 Gsk3b ALK1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALK1 SIGNALING EVENTS ALK1 signaling events Tgfb3 Tgfbr1 Tgfb1 Tgfbr2 Smad7 Csnk2b Arrb2 Ppp1ca Mapk1 Id1 Smad1 Acvrl1 Bmpr2 Fkbp1a Gdf2 Acvr2b Acvr1 Smad5 Inhba Acvr2a E-CADHERIN SIGNALING IN THE NASCENT ADHERENS JUNCTION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E-CADHERIN SIGNALING IN THE NASCENT ADHERENS JUNCTION E-cadherin signaling in the nascent adherens junction Ccnd1 Rap1b Crk Tjp1 Cttn Itgb7 Jup Enah Ctnna1 Klhl20 Rac1 Akt1 Ctnnd1 Iqgap1 Ap1m1 Abi1 Pip5k1c Cdh1 Arf6 Src Dlg1 Rap1a Vav2 Nckap1 Pik3r1 Tiam1 Rhoa Nme1 CLASS I PI3K SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CLASS I PI3K SIGNALING EVENTS Class I PI3K signaling events Fyn Blk Cyth3 Pik3cb Lat Pik3r6 Yes1 Lyn Zap70 Sgk1 Itk LOC103692716 Rac1 Cyth2 Plcg1 Syk Pten Arf6 Src Plekha1 Arf5 Cyth1 Rap1a Kras Fgr Nras Pik3cg Hras Dapp1 Hck Pdpk1 Pik3r1 Lck Foxo3 Rhoa Blnk E-CADHERIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E-CADHERIN SIGNALING EVENTS E-cadherin signaling events Jup Cdh1 PLEXIN-D1 SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLEXIN-D1 SIGNALING Plexin-D1 Signaling Itga11 Vegfa Itga8 Nrp1 Itga10 Pip5k1b Arf6 Itga3 Itga5 Itga6 Itga7 Itgb1 Plxnd1 Sema4a Rras Sema3c Sema3e Rnd2 Itga4 IL27-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL27-MEDIATED SIGNALING EVENTS IL27-mediated signaling events Il2 Jak1 Tgfb1 Ifng Il12a Il17a Gata3 Il6st Stat3 Il27ra Il12b Stat1 Il12rb2 Stat2 Tbx21 Il6 Il1b Il18 Stat5a Ebi3 CLASS IB PI3K NON-LIPID KINASE EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CLASS IB PI3K NON-LIPID KINASE EVENTS Class IB PI3K non-lipid kinase events Pik3cg Map2k1 Pik3r6 Pde3b Mapk1 PLK2 AND PLK4 EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLK2 AND PLK4 EVENTS PLK2 and PLK4 events Plk2 Plk4 PDGF RECEPTOR SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PDGF RECEPTOR SIGNALING NETWORK PDGF receptor signaling network Pdgfb Pdgfrb Pdgfc Pdgfa Pdgfra E-CADHERIN SIGNALING IN KERATINOCYTES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E-CADHERIN SIGNALING IN KERATINOCYTES E-cadherin signaling in keratinocytes Fyn Rac1 Akt1 Plcg1 Ctnnd1 Casr Cdh1 Src Jup Vasp Pik3r1 Egfr Zyx Ctnna1 Ajuba Akt2 Rhoa REGULATION OF NUCLEAR SMAD2 3 SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF NUCLEAR SMAD2 3 SIGNALING Regulation of nuclear SMAD2 3 signaling Esr1 Atf3 Cdkn1a Smad7 Cbfb Smad2 Il5 Myc Zbtb17 Sin3a Gata3 Max Ctbp1 Jun Sap18 Pias3 Hdac1l Ncoa2 E2f5 RGD1561590 Fos Atf2 Rbbp7 Cdk4 Smad3 Hdac2 Hdac1 Cdk2 Snip1 Foxh1 Pias4 Skil Dcp1a Gsc Irf7 Cited1 Runx3 Serpine1 Ifnb1 Foxo3 Runx1 Foxg1 Nkx2-5 Med15 Dlx1 Hnf4a Ncoa1 Il10 Mef2c Tgif1 Sp1 Vdr Crebbp Ar Akt1 Tfe3 Creb1 Foxo1 Kat2a Foxo4 Cdkn2b Col1a2 Myod1 Lamc1 Rbl1 Runx2 SIGNALING EVENTS MEDIATED BY PRL%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY PRL Signaling events mediated by PRL Ccna2 Rhoc Cdkn1a Rac1 Egr1 Ptp4a1 Ptp4a3 Src Rabggtb Atf5 Ccne1 Bcar1 Rabggta Mapk1 Agt Itgb1 Cdk2 Rock1 Rhoa IL2-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL2-MEDIATED SIGNALING EVENTS IL2-mediated signaling events Ifng Grb2 Myc Mapkapk2 Ptpn11 Jun Shc1 Mapk11 Il2 Fos Stam2 Map2k2 Raf1 Stam Ikzf3 Socs1 Syk Mapk14 Mapk8 Kras Mapk1 Nras Cdk2 Irs2 Ptk2b Irs1 Map2k1 Rhoa Fyn Dok2 Jak1 Bcl2 Gab2 Stat3 Rasa1 Stat1 Hras Socs3 Prkcb Il2rg Il2ra Pik3r1 Sos1 Stat5b Lck Stat5a Cish Jak3 Mapk9 AMB2 INTEGRIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AMB2 INTEGRIN SIGNALING amb2 Integrin signaling Rap1b Tln1 Selp Ctgf Rock1 Lrp1 Apob Il6 Ager Itgam Selplg Itgb2 Mmp9 Mst1r Nfkb1 Thy1 Plau Mst1 Plat Jam3 Rap1a Icam1 Mmp2 Hck Plg Rhoa SIGNALING EVENTS MEDIATED BY PTP1B%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY PTP1B Signaling events mediated by PTP1B Fyn Blk Lat Lyn Yes1 Grb2 Crk Leprot Spry2 LOC103693683 Pdgfb Capn1 Nox4 Shc1 Pdgfrb Trpv6 Lepr Csf1r Fer Ybx1 Ptpn1 Itga2b Cdh2 Egfr Prl Akt1 Csf1 Txn1 Src Ins2 Dok1 Lep Bcar1 Csn2 Stat3 Fgr Insr Socs3 Irs1 Hck Csk Pik3r1 Stat5b Lck Rhoa Stat5a REGULATION OF RETINOBLASTOMA PROTEIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RETINOBLASTOMA PROTEIN Regulation of retinoblastoma protein Elf1 Suv39h1l1 Ccna2 Dnmt1 Cdkn1a Aatf Brd2 Rbp2 E2f1 Atf7 LOC100909750 Ccnd1 Bglap Ctbp1 Jun Hdac3 Abl1 Rb1 Mapk11 Skp2 Cdkn1b Hdac1l Ccnd3 Cdk6 Atf2 Raf1 Cdk4 Mapk14 Hdac1 Ccne1 Cdk2 Ubtf Gsc Smarca4 Ppp2ca Cdkn2a Smarcb1 Mdm2 Csf2 Tgfb2 Mef2c Pparg Cebpa Cbx4 Crebbp Mitf E2f3 Myod1 Tbp Spi1 Pax3 Ckm Runx2 Suv39h1 Mapk9 CERAMIDE SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CERAMIDE SIGNALING PATHWAY Ceramide signaling pathway Sphk2 Tradd Tnfrsf1a Ripk1 Myc Cradd Birc3 Ctsd Fadd Pdgfa Bid Casp8 Eif2ak2 Madd Map2k2 Nfkb1 Pawr Raf1 Akt1 Bcl2 Prkcz Bad Map2k4 Smpd1 Ksr1 Traf2 Mapk8 Mapk1 Smpd3 Rela Prkcd Bag4 Prkra LOC100912399 Cycs Asah1 Map2k1 Map3k1 Aifm1 Bax Nfkbia CLASS I PI3K SIGNALING EVENTS MEDIATED BY AKT%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CLASS I PI3K SIGNALING EVENTS MEDIATED BY AKT Class I PI3K signaling events mediated by Akt Cdkn1a Prkdc Akt3 Cdkn1b Bcl2l1 Mtor Raf1 LOC103692716 Akt1 Bad Src Chuk Rictor Sfn Foxo1 Ywhag Mapkap1 Kpna1 Ywhah Foxo4 Casp9 Slc2a4 Ywhaz Pdpk1 Ywhae Prkaca Foxo3 Mlst8 Akt2 Ywhab Gsk3b Gsk3a INTEGRIN-LINKED KINASE SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTEGRIN-LINKED KINASE SIGNALING Integrin-linked kinase signaling Parp1 Ccnd1 Pxn Ppp1r14b Ppp1r14c Jun Ilkap Diaph1 Zeb1 Ppp1r14a Git2 Tns1 Lims2 Myl9 Zyx Parva Arhgef7 Naca Elmo2 Parvb Rhog Nck2 Akt1 LOC103692716 Rac1 Ruvbl2 Iqgap1 Rictor Xpo1 Arhgef6 Creb1 Ruvbl1 Actn1 Cdc37 Snai1 Tacc3 Ilk Ckap5 Ppp1r12a Aurka Gsk3b VALIDATED TRANSCRIPTIONAL TARGETS OF DELTANP63 ISOFORMS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TRANSCRIPTIONAL TARGETS OF DELTANP63 ISOFORMS Validated transcriptional targets of deltaNp63 isoforms Rrad Sec14l2 Notch1 Atm Rab38 Axl Dlx5 Wwp1 Brca2 Stxbp4 Hbp1 Tcf7l1 Ada Bdkrb2 Mre11a Igfbp3 Col5a1 Vdr Nrg1 Adrm1 Hells Hes1 Il1a LOC100911660 Krt14 Sfn Itga3 Ppp2r5a Perp Cdkn2a Runx1 Tp63 Mdm2 Gpx2 Gsk3b T PLK3 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLK3 SIGNALING EVENTS PLK3 signaling events Plk3 Chek2 Cdc25c Tp53 Ccne1 LISSENCEPHALY GENE (LIS1) IN NEURONAL MIGRATION AND DEVELOPMENT%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LISSENCEPHALY GENE (LIS1) IN NEURONAL MIGRATION AND DEVELOPMENT Lissencephaly gene (LIS1) in neuronal migration and development Lrp8 Dynlt1 Vldlr Rac1 Map1b Pafah1b1 Iqgap1 LOC100909750 Cdk5r1 Pafah1b3 Pla2g7 Dab1 Dcx Csnk2a1 Dync1h1 Cdk5r2 Katna1 Cdk5 Reln Abl1 Ywhae Lrpap1 Ndel1 Rhoa ERBB RECEPTOR SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB RECEPTOR SIGNALING NETWORK ErbB receptor signaling network Nrg2 Nrg1 Erbb3 Areg LOC103692716 Tgfa Erbb2 Hbegf Nrg4 Egfr Erbb4 Ereg Nrg3 Btc EPHRIN B REVERSE SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRIN B REVERSE SIGNALING Ephrin B reverse signaling Nck2 Rgs3 Fyn Efnb1 Blk Rac1 Yes1 Lyn Ptpn13 Map2k4 Src Efnb2 Mapk8 Ephb1 Ephb2 Fgr Hck Dnm1 Itga2b Pik3r1 Tiam1 Lck Map3k7 P53 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P53 PATHWAY p53 pathway Ccna2 Atr Atm LOC100909750 Stt3a Daxx Kat5 Trim28 Ube2d1 Setd7 Chek2 Setd8 Fbxo11 Csnk1g2 Nedd8 Rassf1 Csnk1g1 Kat8 Csnk1d Smyd2 Ttc5 Csnk1g3 Rpl23 Abl1 Ppm1d LOC100909949 Skp2 Dyrk2 Mdm4 E4f1 Cse1l Mapk14 Yy1 Usp7 Csnk1e Mapk8 Cdk2 Prkcd Ppp2ca Rpl11 Cdkn2a Mdm2 Gsk3b Hipk2 Pin1 LOC364561 Crebbp Akt1 Prmt5 Ccng1 Ppp2r4 Tp53 Csnk1a1 Rchy1 Mapk9 FOXA1 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXA1 TRANSCRIPTION FACTOR NETWORK FOXA1 transcription factor network Esr1 Serpina1 Brca1 Shh Ndufv3 Xbp1 Pou2f1 Dscam Vtn Nrip1 Foxa1 Jun Atp5j Nr2f2 Prdm15 Foxa2 Apob Foxa3 Cdkn1b Sp1 Fos Crebbp Ar Ap1b1 Nkx3-1 Sod1 Scgb1a1 Gcg Sftpa1 Pisd Ins2 Nfic Tff1 Nfib C4bpb Col18a1 PLASMA MEMBRANE ESTROGEN RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLASMA MEMBRANE ESTROGEN RECEPTOR SIGNALING Plasma membrane estrogen receptor signaling Rock2 Esr1 Grb2 Esr2 Gna14 Gna13 Gnai3 Gna15 Gnao1 Shc1 Gnai2 Gnaz Gnai1 Mapk11 Mmp9 Plcb2 Gna11 Gnal Gnaq Akt1 Gnb1 Plcb1 Msn Src Pelp1 Bcar1 Plcb3 Kras Nras Hras Nos3 Mmp2 Strn Hbegf Pik3r1 Igf1r Sos1 Rhoa ENDOGENOUS TLR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ENDOGENOUS TLR SIGNALING Endogenous TLR signaling Cd14 Ikbkb Irak2 Tlr6 Tirap Vcan Sftpa1 Myd88 Chuk Irak4 Hspd1 S100a8 Tlr4 S100a9 Tlr3 Tlr2 Rhoa IL8- AND CXCR2-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL8- AND CXCR2-MEDIATED SIGNALING EVENTS IL8- and CXCR2-mediated signaling events Cxcr2 Rac2 Arrb2 Pik3r6 Lyn Rab7a Gna14 Gna15 Gnai2 Vasp Dnm1 Arrb1 Plcb2 Pld2 Akt1 Gnb1 Rab11a Plcb1 Plcb3 Fgr Pik3cg Prkcb Cbl Hck Pdpk1 Ppp2r1a Ppp2ca Prkca ATF-2 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATF-2 TRANSCRIPTION FACTOR NETWORK ATF-2 transcription factor network Ccna2 Atf3 Esr1 Ifng Brca1 Ccnd1 Serpinb5 Sele Cbfb Ddit3 Kat5 Ppargc1a Jun Il6 Rb1 Mapk11 Fos Atf2 Cdk4 Ruvbl2 Il23a Mapk14 Gadd45a Mapk8 Mapk1 Th Dusp1 Prkca Dusp5 Dusp10 H2afy Hbg1 Jdp2 Pou2f1 Pdgfra Arg1 Jund Tgfb2 Csrp2 LOC497963 Bcl2l1 Junb Hes1 Plau Bcl2 Cul3 Ins2 Nf1 Creb1 Socs3 Mmp2 Mapk9 ERBB4 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB4 SIGNALING EVENTS ErbB4 signaling events Nrg2 Fyn Wwp1 Pik3cb Tab2 Grb2 Shc1 Cbfa2t3 Dlg4 Prl Lrig1 Nrg1 Mapk1 Erbb2 Hbegf Adam17 Pik3r1 Nrg4 Grin2b Stat5b Erbb4 Mdm2 Ereg Nrg3 Stat5a Btc ANGIOPOIETIN RECEPTOR TIE2-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ANGIOPOIETIN RECEPTOR TIE2-MEDIATED SIGNALING Angiopoietin receptor Tie2-mediated signaling Elf1 Fyn Cdkn1a Nck1 Grb2 Crk Ptpn11 Pxn Rps6kb1 Angpt4 Angpt2 Shc1 Bmx Elf2 Dok2 Ets1 Nfkb1 Agtr1a Pld2 Akt1 Rac1 F2 Mapk14 Pak1 Fgf2 Itga5 Mapk8 Fes Ptk2 Mapk1 Itgb1 Foxo1 Rela Rasa1 Grb7 Tek Nos3 Elk1 Mmp2 Grb14 Angpt1 Pik3r1 Stat5b Fn1 Plg Stat5a CALCINEURIN-REGULATED NFAT-DEPENDENT TRANSCRIPTION IN LYMPHOCYTES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CALCINEURIN-REGULATED NFAT-DEPENDENT TRANSCRIPTION IN LYMPHOCYTES Calcineurin-regulated NFAT-dependent transcription in lymphocytes Csf2 Maf Fosl1 Foxp3 Ifng Ptgs2 Batf3 E2f1 Cd40lg Il4 Faslg Pou2f1 Cblb Il5 Gata3 Jun Pparg Ptpn1 Egr2 Il2 Fos Casp3 Junb Cdk4 Egr1 Egr3 Dgka Slc3a2 Egr4 Tbx21 Il2ra Nfatc2 Nfatc3 Prkcq FOXM1 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXM1 TRANSCRIPTION FACTOR NETWORK FOXM1 transcription factor network Ccna2 Esr1 Xrcc1 Cdk1 Plk1 Lama4 Brca2 Ccnd1 Myc Cdc25b Chek2 Rb1 Skp2 Sp1 Fos Crebbp Cdk4 Cks1l Tgfa Cenpa Ccne1 Cdk2 Mmp2 Map2k1 Foxm1 Cks1b Onecut1 Nfatc3 Cenpf Cdkn2a Aurkb Hspa1b Etv5 Hspa1a Gsk3a TCR SIGNALING IN NÁVE CD4+ T CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TCR SIGNALING IN NÁVE CD4+ T CELLS TCR signaling in na•ve CD4+ T cells Grb2 Ptpn11 Shc1 Bcl10 Ikbkb Pten Chuk Kras Cd3g Sh3bp2 Nras Cd3e Fyb Cd3d Sla2 Cbl Pdpk1 Cd247 Stk39 Csk RT1-Da Prkca RT1-Db1 Ptprc Map3k14 Fyn Lat Nck1 Cd80 Rassf5 Cd28 Lcp2 Dbnl Stim1 Zap70 Rasgrp2 Rasgrp1 Orai1 Itk Trpv6 Cd86 Cd4 Akt1 Gab2 Plcg1 Vav1 Rap1a Traf6 Flna Ptpn6 Map3k8 Hras Map4k1 Prkcb Sos1 Lck Prkcq IL8- AND CXCR1-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL8- AND CXCR1-MEDIATED SIGNALING EVENTS IL8- and CXCR1-mediated signaling events Arrb1 Plcb2 Akt1 Pld1 Gnb1 Arrb2 Pik3r6 Plcb1 Lyn Plcb3 Fgr Gna14 Pik3cg Gna15 Prkcb Cxcr1 Cbl Hck Gnai2 Pdpk1 Dnm1 Prkca Adrbk1 EPHB FORWARD SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHB FORWARD SIGNALING EPHB forward signaling Nck1 Efnb3 Rap1b Grb2 Crk Pxn Rock1 Shc1 Synj1 Itsn1 Dnm1 Efnb1 Kalrn Rac1 Pak1 Src Efnb2 Ephb3 Tf Ephb1 Ptk2 Ephb2 Kras Rap1a Mapk1 Nras Rasa1 Hras Grb7 Rras Map2k1 Pik3r1 SIGNALING EVENTS MEDIATED BY HDAC CLASS I%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HDAC CLASS I Signaling events mediated by HDAC Class I Smad7 Smurf1 Gata1 LOC100911167 Mxd1 Sin3a Btrc Max Hdac8 Mbd2 Mta2 Smg5 LOC100911453 Mbd3 Gatad2b Hdac3 Gatad2a Sap18 Hdac1l RGD1561590 Hdac6 Nfkb1 Rbbp7 Hdac11 Hdac10 Gata2 Hdac2 Yy1 Hdac1 Rela Ube2i Ranbp2 Tnfrsf1a Nr2c1 Ncor2 Pparg Crebbp Wdr77 Prmt5 Sirt5 Fkbp3 Xpo1 Chd4 Sirt4 Chd3 Sirt6 Stat3 Ran Prkaca Nfkbia Hdac4 Sirt3 Sirt2 SIGNALING EVENTS MEDIATED BY STEM CELL FACTOR RECEPTOR (C-KIT)%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY STEM CELL FACTOR RECEPTOR (C-KIT) Signaling events mediated by Stem cell factor receptor (c-Kit) Pik3c2b Stap1 Ptpro Lyn Grb2 LOC100911248 Spred2 Ptpn11 Spred1 Kit Grb10 Kitlg Rps6kb1 Shc1 Fer Crebbp Map2k2 Raf1 Akt1 Socs1 Bcl2 Sh2b2 Bad Pten Tec Mitf Epor Dok1 Epo Mapk8 Vav1 Matk Stat3 Stat1 Ptpn6 Hras Gab1 Map4k1 Cbl Map2k1 Crkl Pdpk1 Pik3r1 Sos1 Foxo3 Stat5a Gsk3b ALTERNATIVE NF-KAPPAB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALTERNATIVE NF-KAPPAB PATHWAY Alternative NF-kappaB pathway Nfkb2 Map3k14 Nfkb1 Chuk Btrc A4B7 INTEGRIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%A4B7 INTEGRIN SIGNALING a4b7 Integrin signaling Itgb1 Madcam1 Pxn Itgb7 Vcam1 Itga4 Rhoa Ptk2 TNF RECEPTOR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TNF RECEPTOR SIGNALING PATHWAY TNF receptor signaling pathway Cyld Tradd Birc2 Tnfrsf1a Ripk1 Tab2 Birc3 Fadd Casp8 Madd Nrk Tnfrsf1b Map2k7 Nfkb1 Ikbkb Prkcz Txn1 Smpd1 Chuk Traf2 Map3k3 Rela Stat1 Bag4 LOC100912399 Tnik Prkci Map3k1 Adam17 Nsmaf Map4k5 Sqstm1 Map4k3 Map3k7 Rffl Map4k2 Smpd2 C-MYC PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%C-MYC PATHWAY C-MYC pathway Ruvbl2 Actl6a Pak2 Pml Hbp1 Myc Zbtb17 Kat5 Max Ruvbl1 Ppp2r5a Kat2a Pin1 Supt7l LOC364561 Ppp2ca Skp2 Cdkn2a Taf9 Gsk3b VEGF AND VEGFR SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VEGF AND VEGFR SIGNALING NETWORK VEGF and VEGFR signaling network Vegfc Flt4 LOC100911280 Figf Vegfa Flt1 Nrp2 Nrp1 Pgf ERBB2 ERBB3 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB2 ERBB3 SIGNALING EVENTS ErbB2 ErbB3 signaling events Nrg2 Pik3cb Grb2 Ptpn11 Jun Shc1 Usp8 Chrna1 Mapk10 Nrg1 Fos Mtor Erbb3 Map2k2 Raf1 Rac1 Akt1 Bad Ppp3cb Src Mapk8 Kras Mapk1 Stat3 Erbb2 Nras Nf2 Hras Nfatc4 Rnf41 Chrne Map2k1 Prkaca Pik3r1 Sos1 Mapk9 S1P5 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P5 PATHWAY S1P5 pathway Gna12 Gnai3 S1pr5 Gnao1 Gnai2 Gnaz Gnai1 Rhoa FGF SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FGF SIGNALING PATHWAY FGF signaling pathway Fgfr3 Fgfr4 Il17rd Fgf1 Fgfr2 Grb2 Fgf23 Ncam1 Fgf19 Bglap Spp1 Ptpn11 Cttn Spry2 Jun Shc1 Cdh2 Hgf Mmp9 Fos Frs2 Plau Fgfr1 Akt1 Plcg1 Ctnnd1 Mapk14 Cdh1 Src Mapk1 Stat3 Sdc2 Stat1 Ptk2b Dusp6 Gab1 Camk2a Cbl Pak4 Pdpk1 Sdc4 Pik3r1 Sos1 Stat5b Ssh1 Runx2 Rps6ka1 BARD1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BARD1 SIGNALING EVENTS BARD1 signaling events Xrcc6 Atr LOC100911267 Atm Ube2d3 Ewsr1 Brca1 Fancd2 Rad51 Rbbp8 Topbp1 Fanca Prkdc Fancc Fancl Fance Fancf Mre11a Bard1 Nbn Cstf1 LOC100912481 Rad50 Pcna Ccne1 Cdk2 Tp53 Xrcc5 Ube2l3 SIGNALING EVENTS MEDIATED BY FOCAL ADHESION KINASE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY FOCAL ADHESION KINASE Signaling events mediated by focal adhesion kinase Ccnd1 Yes1 Grb2 Vcl Crk Jun Acta1 Arhgef11 Arhgef7 Ets1 Raf1 Rac1 Pak1 Src Itga5 Mapk8 Bcar1 Ptk2 Mapk1 Itgb1 Actn1 Grb7 Map2k1 Mapk8ip3 Rhoa Rock2 Fyn Nck1 Rap1b Tln1 Pxn Git2 Arhgap26 Bmx Asap1 Nck2 Plcg1 Arhgef28 Map2k4 LOC100909609 Rap1a Dock1 Rasa1 Rras Capn2 Pik3r1 Sos1 Arhgap35 Mapk9 GLYPICAN 1 NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN 1 NETWORK Glypican 1 network Tgfb3 Blk Fyn Prnp Yes1 Lyn Smad2 Serpinc1 Tdgf1 Pla2g2a Slit2 Nrg1 Tgfbr1 Tgfb1 Tgfbr2 LOC100911280 Fgfr1 Vegfa Flt1 Src Fgf2 Fgr App Hck Lama1 Lck HIF-2-ALPHA TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HIF-2-ALPHA TRANSCRIPTION FACTOR NETWORK HIF-2-alpha transcription factor network Twist1 Arnt Adora2a Pou5f1 Apex1 Slc11a2 Eif3e Mmp14 Epas1 Sp1 Crebbp Ets1 LOC100911280 Vegfa Flt1 Abcg2 Pgk1 Bhlhe40 Slc2a1 Epo Cited2 Tceb1 Egln2 Egln3 Vhl Efna1 Elk1 Hif1an Serpine1 ALPHA6 BETA4 INTEGRIN-LIGAND INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA6 BETA4 INTEGRIN-LIGAND INTERACTIONS Alpha6 beta4 integrin-ligand interactions Lamb2 Lamb3 Lama1 Lamb1 Lamc1 Lamc2 Itga6 Itgb4 SIGNALING MEDIATED BY P38-GAMMA AND P38-DELTA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING MEDIATED BY P38-GAMMA AND P38-DELTA Signaling mediated by p38-gamma and p38-delta Snta1 Eef2k Map2k6 Mapk13 Ccnd1 Stmn1 Mapk12 Pkn1 UROKINASE-TYPE PLASMINOGEN ACTIVATOR (UPA) AND UPAR-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%UROKINASE-TYPE PLASMINOGEN ACTIVATOR (UPA) AND UPAR-MEDIATED SIGNALING Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling Crk Vtn Elane Pdgfrb Lrp1 Egfr Itgam Hgf Itgb2 Mmp9 Ctrc Klk4 Fpr3 Tgfb1 Fpr2 Vldlr Plau Ctsg Rac1 Fpr1 Fgg Fgb Src Fga Gpld1 Itga3 Itga5 Bcar1 Mmp12 LOC100909609 Mmp13 Itgb1 Dock1 Fn1 Serpine1 Plg HEDGEHOG SIGNALING EVENTS MEDIATED BY GLI PROTEINS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HEDGEHOG SIGNALING EVENTS MEDIATED BY GLI PROTEINS Hedgehog signaling events mediated by Gli proteins Shh Arrb2 Sin3a Btrc Smo Gnai3 Csnk1g2 Csnk1g1 Gnao1 Csnk1d Csnk1g3 Gnai2 Foxa2 Ptch1 Gnaz Sap18 Gnai1 Gli2 Pias1 Hdac1l Fbxw11 RGD1561590 Crebbp Rbbp7 Akt1 Gnb1 Hdac2 Hdac1 Csnk1e Xpo1 Kif3a Stk36 Ift88 Prkcd Rab23 Sufu Mtss1 Gli1 Map2k1 Spop Lgals3 Prkaca Csnk1a1 Gsk3b REGULATION OF RAC1 ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RAC1 ACTIVITY Regulation of RAC1 activity Ngef LOC100912512 Vav3 Rap1gds1 Def6 Dock6 Arhgef7 Ralbp1 Spata13 Kalrn Rac1 Arhgef25 Arhgap9 Arhgef2 Arhgap1 Abi1 Prex1 Abr Prex2 Arhgap17 Racgap1 Arhgef6 Trio Vav1 LOC100909609 Dock1 Eps8 Vav2 Arhgdia Sos1 Tiam1 IL12 SIGNALING MEDIATED BY STAT4%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL12 SIGNALING MEDIATED BY STAT4 IL12 signaling mediated by STAT4 Ifng Cd80 Cd28 Jun Cd86 Irf1 Fos Il2 Crebbp Tgfb1 Cd4 Il13 Mapk8 Cd3g Stat3 Cd3e Cd3d Stat1 Il18r1 Tbx21 Cd247 Pias2 Il2ra RT1-Da Il18 RT1-Db1 Etv5 Mapk9 HIV-1 NEF: NEGATIVE EFFECTOR OF FAS AND TNF-ALPHA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HIV-1 NEF: NEGATIVE EFFECTOR OF FAS AND TNF-ALPHA HIV-1 Nef: Negative effector of Fas and TNF-alpha Map3k14 Tradd Tnfrsf1a Ripk1 Cflar Casp6 Faslg Daxx Apaf1 Cradd Fas Birc3 Fadd Casp2 Bid Casp8 Map2k7 Casp3 Nfkb1 Bcl2 Chuk Traf2 Mapk8 Rela Casp9 Bag4 Cycs Cd247 Nfkbia