Dataset | Set_03_wtNotch_versus_normalThy.phenotype_wtNotch_versus_normalThy.cls #wtNotch_versus_normalThy.phenotype_wtNotch_versus_normalThy.cls #wtNotch_versus_normalThy_repos |
Phenotype | phenotype_wtNotch_versus_normalThy.cls#wtNotch_versus_normalThy_repos |
Upregulated in class | wtNotch |
GeneSet | REACTOME_DIABETES_PATHWAYS |
Enrichment Score (ES) | 0.639039 |
Normalized Enrichment Score (NES) | 1.5401522 |
Nominal p-value | 0.003327787 |
FDR q-value | 0.1151463 |
FWER p-Value | 0.884 |
PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
---|---|---|---|---|---|---|---|---|
1 | RPL38 | 70040 4060138 6200601 | 2 | 8.396 | 0.1368 | Yes | ||
2 | PGK1 | 1570494 630300 | 8 | 5.004 | 0.2181 | Yes | ||
3 | PKM2 | 6520403 70500 | 34 | 3.793 | 0.2786 | Yes | ||
4 | TPI1 | 1500215 2100154 | 44 | 3.470 | 0.3347 | Yes | ||
5 | F2 | 5720280 | 120 | 2.310 | 0.3684 | Yes | ||
6 | ATF4 | 730441 1740195 | 203 | 1.842 | 0.3939 | Yes | ||
7 | RPS24 | 5420377 | 453 | 1.188 | 0.3998 | Yes | ||
8 | IDH3A | 460332 | 517 | 1.096 | 0.4143 | Yes | ||
9 | SEC61B | 840113 4540687 | 543 | 1.060 | 0.4302 | Yes | ||
10 | RPS3A | 2470086 | 610 | 0.998 | 0.4429 | Yes | ||
11 | RPS19 | 5860066 | 672 | 0.943 | 0.4550 | Yes | ||
12 | ATP5G1 | 5290019 | 729 | 0.902 | 0.4667 | Yes | ||
13 | NDUFS3 | 1690136 5340528 | 777 | 0.874 | 0.4784 | Yes | ||
14 | CYCS | 2030072 | 807 | 0.851 | 0.4907 | Yes | ||
15 | ETFB | 2690025 | 811 | 0.850 | 0.5044 | Yes | ||
16 | NDUFA10 | 5570347 | 834 | 0.826 | 0.5167 | Yes | ||
17 | NDUFB8 | 2260450 | 921 | 0.750 | 0.5242 | Yes | ||
18 | UQCRC1 | 520053 | 1040 | 0.664 | 0.5287 | Yes | ||
19 | MDH2 | 1850601 | 1135 | 0.607 | 0.5335 | Yes | ||
20 | DDOST | 2680731 | 1275 | 0.548 | 0.5349 | Yes | ||
21 | NDUFV1 | 5420369 | 1337 | 0.522 | 0.5401 | Yes | ||
22 | ATP5C1 | 5910601 | 1342 | 0.520 | 0.5484 | Yes | ||
23 | SSR4 | 1340619 4150132 | 1450 | 0.479 | 0.5504 | Yes | ||
24 | NDUFA8 | 3460491 | 1647 | 0.409 | 0.5464 | Yes | ||
25 | SEC61G | 4120725 | 1648 | 0.409 | 0.5531 | Yes | ||
26 | PDHA1 | 5550397 | 1693 | 0.392 | 0.5571 | Yes | ||
27 | ATP5E | 4120411 | 1699 | 0.391 | 0.5632 | Yes | ||
28 | NDUFA6 | 3990348 | 1706 | 0.389 | 0.5692 | Yes | ||
29 | UQCR | 6130025 | 1712 | 0.386 | 0.5752 | Yes | ||
30 | UQCRB | 1450047 | 1767 | 0.372 | 0.5784 | Yes | ||
31 | SRP72 | 3990427 | 1789 | 0.367 | 0.5832 | Yes | ||
32 | NDUFB5 | 110685 | 1793 | 0.364 | 0.5890 | Yes | ||
33 | SDHD | 2570128 | 1822 | 0.357 | 0.5933 | Yes | ||
34 | NDUFB7 | 1850026 | 1882 | 0.340 | 0.5956 | Yes | ||
35 | SSR2 | 5390180 | 1923 | 0.328 | 0.5988 | Yes | ||
36 | NDUFS7 | 1740142 | 1929 | 0.327 | 0.6039 | Yes | ||
37 | NDUFB10 | 5900576 | 1978 | 0.314 | 0.6064 | Yes | ||
38 | ATP5D | 6550167 | 2044 | 0.298 | 0.6077 | Yes | ||
39 | NDUFS2 | 4850020 6200402 | 2059 | 0.293 | 0.6118 | Yes | ||
40 | RPS4X | 2690020 | 2115 | 0.280 | 0.6134 | Yes | ||
41 | RPS23 | 7100594 | 2146 | 0.272 | 0.6162 | Yes | ||
42 | RPS15A | 1170180 | 2172 | 0.268 | 0.6192 | Yes | ||
43 | ATP5A1 | 1990722 | 2195 | 0.262 | 0.6223 | Yes | ||
44 | RPL14 | 5080471 | 2209 | 0.259 | 0.6258 | Yes | ||
45 | COX5B | 6550670 | 2292 | 0.238 | 0.6252 | Yes | ||
46 | PFKFB2 | 3940538 7100059 | 2307 | 0.235 | 0.6283 | Yes | ||
47 | ATP5O | 7000398 | 2311 | 0.234 | 0.6319 | Yes | ||
48 | CS | 5080600 | 2436 | 0.210 | 0.6286 | Yes | ||
49 | ETFDH | 4670358 | 2451 | 0.206 | 0.6312 | Yes | ||
50 | NDUFS8 | 4150100 | 2467 | 0.204 | 0.6337 | Yes | ||
51 | SDHB | 3120398 4780113 3710435 | 2612 | 0.178 | 0.6289 | Yes | ||
52 | RPL5 | 840095 | 2647 | 0.173 | 0.6298 | Yes | ||
53 | RPS3 | 1570017 2370170 | 2666 | 0.171 | 0.6316 | Yes | ||
54 | DLD | 4150403 6590341 | 2678 | 0.169 | 0.6338 | Yes | ||
55 | COX8A | 3780500 | 2690 | 0.167 | 0.6359 | Yes | ||
56 | ATP5I | 6220047 | 2695 | 0.166 | 0.6384 | Yes | ||
57 | ATP5F1 | 7000725 | 2733 | 0.161 | 0.6390 | Yes | ||
58 | COX6C | 1400020 | 2842 | 0.146 | 0.6356 | No | ||
59 | RPS2 | 1340647 | 2866 | 0.144 | 0.6367 | No | ||
60 | NDUFC2 | 580075 | 2909 | 0.138 | 0.6367 | No | ||
61 | HSPA5 | 5130671 | 3005 | 0.130 | 0.6336 | No | ||
62 | NDUFA9 | 2260280 | 3156 | 0.115 | 0.6274 | No | ||
63 | COX7B | 2340504 | 3213 | 0.110 | 0.6261 | No | ||
64 | RPL37A | 7040717 | 3221 | 0.110 | 0.6276 | No | ||
65 | RPL4 | 2940014 5420324 | 3322 | 0.099 | 0.6238 | No | ||
66 | RPL18A | 4570619 | 3327 | 0.099 | 0.6252 | No | ||
67 | RPS13 | 1570364 | 3408 | 0.092 | 0.6223 | No | ||
68 | UQCRC2 | 5550091 | 3452 | 0.089 | 0.6214 | No | ||
69 | NDUFA11 | 3780333 | 3489 | 0.086 | 0.6209 | No | ||
70 | MBTPS1 | 1230273 4850152 6860605 | 3524 | 0.083 | 0.6204 | No | ||
71 | NDUFAB1 | 1980091 | 3623 | 0.076 | 0.6163 | No | ||
72 | RPS17 | 2360528 | 3780 | 0.065 | 0.6089 | No | ||
73 | PRKCA | 6400551 | 3810 | 0.064 | 0.6084 | No | ||
74 | IGFBP6 | 1580181 | 3811 | 0.063 | 0.6094 | No | ||
75 | RPL27A | 3130451 110195 6840494 | 3837 | 0.062 | 0.6091 | No | ||
76 | SLC2A2 | 5130537 5720722 6770079 | 3873 | 0.061 | 0.6082 | No | ||
77 | IDH3G | 6860706 | 3908 | 0.059 | 0.6073 | No | ||
78 | NDUFA7 | 5900722 | 4054 | 0.052 | 0.6003 | No | ||
79 | SRP54 | 2970605 | 4263 | 0.044 | 0.5898 | No | ||
80 | KLF4 | 1850022 3830239 5570750 | 4373 | 0.041 | 0.5845 | No | ||
81 | EIF2S1 | 5360292 | 4459 | 0.039 | 0.5806 | No | ||
82 | CHRM3 | 6110725 | 4593 | 0.035 | 0.5739 | No | ||
83 | PLA2G7 | 4730092 | 4640 | 0.034 | 0.5720 | No | ||
84 | ERN1 | 2360403 | 4692 | 0.033 | 0.5698 | No | ||
85 | IGF1 | 1990193 3130377 3290280 | 4924 | 0.029 | 0.5577 | No | ||
86 | GCG | 6220735 | 5145 | 0.025 | 0.5462 | No | ||
87 | RPSA | 2360408 2680736 | 5222 | 0.024 | 0.5425 | No | ||
88 | NDUFB4 | 460348 5690594 | 5271 | 0.024 | 0.5403 | No | ||
89 | NDUFS5 | 4010692 | 5345 | 0.023 | 0.5367 | No | ||
90 | UQCRFS1 | 6620576 | 6896 | 0.010 | 0.4529 | No | ||
91 | KCNJ11 | 2510131 | 6999 | 0.010 | 0.4475 | No | ||
92 | EXOC5 | 7000711 | 7051 | 0.010 | 0.4449 | No | ||
93 | SRP19 | 780450 3120075 | 7114 | 0.009 | 0.4417 | No | ||
94 | ATP5J | 4210100 6900288 | 7398 | 0.008 | 0.4265 | No | ||
95 | RPL41 | 6940112 | 7654 | 0.007 | 0.4128 | No | ||
96 | RPL17 | 2690167 5690504 | 7848 | 0.006 | 0.4025 | No | ||
97 | SUCLG1 | 1850082 5290270 | 7985 | 0.006 | 0.3952 | No | ||
98 | GLP1R | 6420528 | 8327 | 0.004 | 0.3768 | No | ||
99 | ADRA2A | 5340520 | 8449 | 0.004 | 0.3703 | No | ||
100 | FFAR1 | 540112 | 8773 | 0.003 | 0.3528 | No | ||
101 | ATP5J2 | 2630706 | 8801 | 0.003 | 0.3514 | No | ||
102 | NKX2-2 | 4150731 | 8820 | 0.003 | 0.3505 | No | ||
103 | LEP | 4010053 | 9480 | 0.001 | 0.3148 | No | ||
104 | KIF5B | 770397 5420168 | 9915 | -0.001 | 0.2913 | No | ||
105 | SDHA | 7000056 | 10242 | -0.002 | 0.2737 | No | ||
106 | IGFBP1 | 5720435 | 10359 | -0.002 | 0.2674 | No | ||
107 | RAP1A | 1090025 | 11438 | -0.006 | 0.2091 | No | ||
108 | PFKFB1 | 2370128 | 12179 | -0.009 | 0.1691 | No | ||
109 | PDX1 | 6660647 | 12343 | -0.010 | 0.1605 | No | ||
110 | CTSL1 | 2350519 | 12691 | -0.011 | 0.1419 | No | ||
111 | ABCC8 | 2810671 3120671 | 12878 | -0.013 | 0.1320 | No | ||
112 | RPS21 | 3120673 | 13028 | -0.014 | 0.1241 | No | ||
113 | IGFBP5 | 2360592 | 13075 | -0.014 | 0.1219 | No | ||
114 | RPL27 | 1940088 | 13264 | -0.016 | 0.1119 | No | ||
115 | SYT5 | 4150082 | 13411 | -0.017 | 0.1043 | No | ||
116 | COX6B1 | 3710440 6180438 | 13488 | -0.018 | 0.1005 | No | ||
117 | RPL18 | 6380181 3870195 | 13857 | -0.023 | 0.0809 | No | ||
118 | RPL37 | 3170494 3870750 4280494 | 13863 | -0.023 | 0.0810 | No | ||
119 | RPS28 | 3830221 | 13892 | -0.023 | 0.0799 | No | ||
120 | PCSK2 | 360017 430528 5900619 | 14369 | -0.032 | 0.0546 | No | ||
121 | CPE | 2940441 | 14462 | -0.034 | 0.0502 | No | ||
122 | IGFALS | 6350195 | 14526 | -0.036 | 0.0474 | No | ||
123 | RPLP2 | 5290020 | 14574 | -0.038 | 0.0455 | No | ||
124 | KLK3 | 1500278 | 14628 | -0.039 | 0.0432 | No | ||
125 | RPS20 | 1740092 | 14729 | -0.043 | 0.0385 | No | ||
126 | RPL39 | 2370446 | 14744 | -0.043 | 0.0384 | No | ||
127 | COX7C | 2470047 | 14891 | -0.050 | 0.0313 | No | ||
128 | OGDH | 3840333 6350100 | 14904 | -0.050 | 0.0315 | No | ||
129 | RPL6 | 6040735 | 15133 | -0.062 | 0.0202 | No | ||
130 | RPS16 | 510722 | 15161 | -0.064 | 0.0198 | No | ||
131 | COX4I1 | 5340427 | 15177 | -0.065 | 0.0200 | No | ||
132 | RPS14 | 430541 | 15242 | -0.069 | 0.0177 | No | ||
133 | RPS5 | 580093 | 15284 | -0.072 | 0.0166 | No | ||
134 | SEC11A | 6420563 | 15499 | -0.091 | 0.0065 | No | ||
135 | VAMP2 | 2100100 | 15502 | -0.091 | 0.0079 | No | ||
136 | COX6A1 | 1050095 1450239 | 15532 | -0.093 | 0.0078 | No | ||
137 | RPS25 | 520139 | 15536 | -0.093 | 0.0092 | No | ||
138 | RPL8 | 20296 | 15620 | -0.102 | 0.0063 | No | ||
139 | RPLP1 | 3140292 | 15634 | -0.103 | 0.0073 | No | ||
140 | RPL28 | 6900136 | 15763 | -0.116 | 0.0023 | No | ||
141 | PRKAR2B | 3130593 5220577 | 15903 | -0.134 | -0.0031 | No | ||
142 | FAU | 7100465 | 15915 | -0.136 | -0.0014 | No | ||
143 | ATP5B | 3870138 | 15922 | -0.137 | 0.0005 | No | ||
144 | RPS29 | 580324 | 16104 | -0.163 | -0.0067 | No | ||
145 | RPL19 | 5550592 | 16277 | -0.188 | -0.0129 | No | ||
146 | NDUFB3 | 4610687 | 16363 | -0.203 | -0.0142 | No | ||
147 | RPL11 | 3780435 | 16735 | -0.271 | -0.0299 | No | ||
148 | SLC30A7 | 2230463 | 16831 | -0.297 | -0.0302 | No | ||
149 | SRP14 | 5390747 | 16888 | -0.310 | -0.0282 | No | ||
150 | MMP2 | 2570603 | 16915 | -0.316 | -0.0244 | No | ||
151 | IQGAP1 | 6660494 | 17105 | -0.375 | -0.0286 | No | ||
152 | NDUFA4 | 6860364 | 17112 | -0.377 | -0.0227 | No | ||
153 | NDUFA2 | 6020100 | 17153 | -0.393 | -0.0185 | No | ||
154 | NFYA | 5860368 | 17275 | -0.443 | -0.0178 | No | ||
155 | NDUFS4 | 510142 1240148 4760253 | 17739 | -0.668 | -0.0320 | No | ||
156 | EXOC8 | 5860133 | 17814 | -0.728 | -0.0241 | No | ||
157 | NDUFC1 | 2570377 4200239 | 18059 | -0.947 | -0.0219 | No | ||
158 | IGFBP4 | 2680309 5420441 | 18204 | -1.158 | -0.0108 | No | ||
159 | GNAS | 630441 1850373 4050152 | 18468 | -2.029 | 0.0080 | No |