Details for gene set HSA04010_MAPK_SIGNALING

Table: GSEA Results Summary

Dataset	Set_04_transDMproB_versus_DMpreB.phenotype_transDMproB_versus_DMpreB.cls #transDMproB_versus_DMpreB.phenotype_transDMproB_versus_DMpreB.cls #transDMproB_versus_DMpreB_repos
Phenotype	phenotype_transDMproB_versus_DMpreB.cls#transDMproB_versus_DMpreB_repos
Upregulated in class	transDMproB
GeneSet	HSA04010_MAPK_SIGNALING_PATHWAY
Enrichment Score (ES)	0.56263006
Normalized Enrichment Score (NES)	1.5755945
Nominal p-value	0.0
FDR q-value	0.17516588
FWER p-Value	0.715

Table: GSEA details [plain text format]
	PROBE	DESCRIPTION (from dataset)	RANK IN GENE LIST	RANK METRIC SCORE	RUNNING ES	CORE ENRICHMENT
1	MAPKAPK2	13838	85	7.980	0.0280	Yes
2	MAP3K3	20626	173	6.715	0.0507	Yes
3	GADD45A	17129	198	6.482	0.0759	Yes
4	PRKACB	15140	286	5.707	0.0944	Yes
5	RASGRP2	9693	358	5.214	0.1119	Yes
6	RRAS2	12431	366	5.170	0.1326	Yes
7	MAP3K7IP2	19827	402	4.966	0.1510	Yes
8	RAC2	22217	404	4.956	0.1712	Yes
9	MAPK14	23313	429	4.797	0.1895	Yes
10	NFKB2	23810	491	4.513	0.2046	Yes
11	DUSP1	23061	532	4.376	0.2203	Yes
12	DDIT3	19857	544	4.335	0.2374	Yes
13	DUSP2	14865	607	4.040	0.2506	Yes
14	TGFB1	18332	616	4.024	0.2666	Yes
15	PTPN7	11500	659	3.836	0.2799	Yes
16	MAP4K3	22887	676	3.780	0.2945	Yes
17	DUSP6	19891 3399	703	3.694	0.3082	Yes
18	MAPK1	1642 11167	721	3.643	0.3222	Yes
19	RRAS	18256	735	3.612	0.3362	Yes
20	MEF2C	3204 9378	826	3.362	0.3450	Yes
21	RASA1	10174	860	3.276	0.3566	Yes
22	MAP3K14	11998	884	3.224	0.3686	Yes
23	MKNK2	3299 9392	940	3.070	0.3781	Yes
24	RPS6KA4	23804	985	2.977	0.3879	Yes
25	MAP4K2	6457	1046	2.839	0.3962	Yes
26	TRAF6	5797 14940	1138	2.646	0.4021	Yes
27	STK4	14743	1158	2.598	0.4116	Yes
28	MAPK9	1233 20903 1383	1236	2.449	0.4175	Yes
29	PPP3CC	21763	1270	2.374	0.4254	Yes
30	KRAS	9247	1320	2.284	0.4320	Yes
31	MAP4K4	11241	1329	2.268	0.4409	Yes
32	MAP3K1	21348	1355	2.218	0.4486	Yes
33	PPP3CB	5285	1370	2.196	0.4568	Yes
34	PPM1B	5280 1567 5281	1420	2.116	0.4627	Yes
35	SOS2	21049	1479	2.025	0.4679	Yes
36	AKT3	13739 982	1498	1.998	0.4751	Yes
37	CRKL	4560	1532	1.945	0.4812	Yes
38	GRB2	20149	1534	1.943	0.4891	Yes
39	MAP2K3	20856	1601	1.864	0.4931	Yes
40	NFKB1	15160	1611	1.847	0.5002	Yes
41	JUN	15832	1670	1.759	0.5042	Yes
42	PPM1A	5279 9607	1673	1.756	0.5113	Yes
43	PRKCB1	1693 9574	1709	1.712	0.5164	Yes
44	ARRB2	20806	1715	1.707	0.5231	Yes
45	MAP3K5	20079 11166	1721	1.701	0.5297	Yes
46	GNG12	4789	1739	1.677	0.5357	Yes
47	CACNA2D1	8676	1742	1.673	0.5424	Yes
48	TP53	20822	1912	1.507	0.5393	Yes
49	EGF	15169	2044	1.359	0.5378	Yes
50	MAP3K4	23126	2216	1.200	0.5334	Yes
51	TRAF2	14657	2284	1.132	0.5343	Yes
52	IL1B	14431	2370	1.061	0.5341	Yes
53	MAX	21034	2381	1.044	0.5378	Yes
54	CACNB2	4466 8678	2406	1.023	0.5406	Yes
55	MAP3K7IP1	2193 2171 22419	2426	1.011	0.5437	Yes
56	FGF13	4720 8963 2627	2430	1.006	0.5477	Yes
57	MAP3K8	23495	2479	0.989	0.5491	Yes
58	RAP1B	10083	2493	0.978	0.5524	Yes
59	RASA2	4329	2496	0.973	0.5563	Yes
60	RAC1	16302	2500	0.969	0.5601	Yes
61	MAPK3	6458 11170	2529	0.941	0.5624	Yes
62	RPS6KA1	15725	2592	0.884	0.5626	Yes
63	FOS	21202	2723	0.766	0.5587	No
64	PAK1	9527	2767	0.720	0.5593	No
65	CD14	23452	2769	0.719	0.5622	No
66	ACVR1B	4335 22353	2853	0.647	0.5603	No
67	MAP3K7	16255	2925	0.600	0.5589	No
68	RAF1	17035	2978	0.564	0.5584	No
69	MYC	22465 9435	3045	0.531	0.5569	No
70	MAP2K1	19082	3106	0.498	0.5557	No
71	MAPK13	23314	3119	0.491	0.5571	No
72	NF1	5165	3151	0.469	0.5573	No
73	FGFR2	1917 4722 1119	3175	0.460	0.5579	No
74	PDGFRB	23539	3283	0.411	0.5538	No
75	RASGRP4	6119	3284	0.411	0.5555	No
76	MAPK8IP3	11402 23080	3412	0.354	0.5500	No
77	CDC25B	14841	3504	0.319	0.5463	No
78	MAP2K5	19088	3538	0.306	0.5458	No
79	GNA12	9023	3615	0.280	0.5428	No
80	DUSP7	10661	3639	0.273	0.5427	No
81	RASGRP1	5360 14476 9694	3731	0.247	0.5387	No
82	PDGFA	5237	3795	0.231	0.5362	No
83	MAP3K10	3831 17916	3901	0.204	0.5314	No
84	CASP3	8693	3937	0.195	0.5303	No
85	SRF	22961 1597	4078	0.167	0.5233	No
86	FAS	23881 3750	4108	0.163	0.5224	No
87	ARRB1	3890 8465 18178 4276	4125	0.160	0.5222	No
88	DUSP4	18632 3820	4129	0.160	0.5227	No
89	MAPK7	1381 20414	4277	0.138	0.5152	No
90	STK3	7084	4281	0.137	0.5156	No
91	FGF18	4721 1351	4350	0.127	0.5125	No
92	TNF	23004	4390	0.120	0.5108	No
93	DAXX	23290	4398	0.119	0.5109	No
94	CACNA1E	4465	4423	0.116	0.5101	No
95	MAP3K6	16054	4631	0.093	0.4992	No
96	SOS1	5476	4708	0.086	0.4954	No
97	ACVR1C	14585	4847	0.076	0.4882	No
98	CRK	4559 1249	4878	0.075	0.4869	No
99	CACNA1F	12054 24393	4929	0.072	0.4845	No
100	RAC3	20561	4975	0.069	0.4823	No
101	PLA2G2D	16018	5180	0.059	0.4715	No
102	CDC42	4503 8722 4504 2465	5195	0.059	0.4709	No
103	PPP3R1	9611 489	5287	0.055	0.4662	No
104	TGFBR1	16213 10165 5745	5354	0.052	0.4628	No
105	FGF4	8964	5366	0.051	0.4624	No
106	PPP3R2	9612	6016	0.032	0.4273	No
107	NR4A1	9099	6019	0.032	0.4273	No
108	MAP3K2	11165	6025	0.032	0.4271	No
109	DUSP9	24307	6160	0.029	0.4200	No
110	FGF21	17830	6166	0.029	0.4198	No
111	FGF1	1994 23447	6173	0.029	0.4196	No
112	DUSP16	1004 7699	6387	0.025	0.4081	No
113	CACNA1D	4464 8675	6388	0.025	0.4082	No
114	IL1R2	14265	6446	0.024	0.4052	No
115	PDGFB	22199 2311	6625	0.020	0.3956	No
116	PLA2G12B	20016	6684	0.019	0.3925	No
117	PLA2G1B	9581	6712	0.018	0.3911	No
118	FGF16	24270	6717	0.018	0.3910	No
119	CACNA1H	23077	7103	0.012	0.3701	No
120	PRKX	9619 5290	7253	0.010	0.3620	No
121	FASLG	13789	7673	0.004	0.3393	No
122	FGF7	8965	7874	0.002	0.3284	No
123	FGF14	21716 3005 3463	8086	-0.001	0.3169	No
124	FGF5	16785	8104	-0.001	0.3160	No
125	FGFR1	3789 8968	8129	-0.002	0.3147	No
126	NTF5	18248	8312	-0.004	0.3048	No
127	PLA2G3	20968	8330	-0.005	0.3039	No
128	CACNG3	12029	8441	-0.006	0.2979	No
129	RPS6KA2	9759 9758	8473	-0.006	0.2963	No
130	RPS6KA5	2076 21005	8560	-0.007	0.2916	No
131	MRAS	9409	8608	-0.008	0.2891	No
132	NTRK2	9491	8794	-0.011	0.2791	No
133	CACNG7	13497	8816	-0.011	0.2780	No
134	PLA2G5	9583	9022	-0.014	0.2669	No
135	CACNG6	7033	9161	-0.016	0.2594	No
136	MOS	16254	9303	-0.018	0.2518	No
137	CACNG5	1339 20175	9355	-0.019	0.2491	No
138	NFATC2	5168 2866	9389	-0.019	0.2474	No
139	MAPKAPK5	16387	9652	-0.023	0.2333	No
140	RPS6KA6	12458	9782	-0.025	0.2264	No
141	FGF8	23656	9837	-0.026	0.2235	No
142	TAOK2	10610 3794	9987	-0.028	0.2155	No
143	FGF12	1723 22621	9994	-0.028	0.2153	No
144	AKT2	4365 4366	10089	-0.030	0.2103	No
145	PLA2G2E	16016	10110	-0.030	0.2094	No
146	CACNG4	20176	10152	-0.031	0.2073	No
147	CACNG8	13498	10185	-0.032	0.2056	No
148	RAP1A	8467	10262	-0.033	0.2016	No
149	IKBKG	2570 2562 4908	10350	-0.035	0.1971	No
150	EVI1	4689 8926	10413	-0.036	0.1938	No
151	FGF11	20383	10697	-0.040	0.1786	No
152	FGF10	4719 8962	10752	-0.041	0.1758	No
153	CACNB3	22373 8679	10781	-0.042	0.1745	No
154	FLNC	4302 8510	11217	-0.051	0.1510	No
155	CACNA1A	4461	11245	-0.051	0.1498	No
156	PLA2G10	22658	11323	-0.053	0.1458	No
157	NFATC4	22002	11337	-0.054	0.1453	No
158	MAP2K7	6453	11507	-0.057	0.1363	No
159	PLA2G4A	13809	11626	-0.061	0.1302	No
160	PLA2G2A	16017	11635	-0.061	0.1300	No
161	PRKCA	20174	11681	-0.062	0.1278	No
162	BDNF	14926 2797	11691	-0.062	0.1275	No
163	FGF20	18892	11835	-0.067	0.1200	No
164	CACNA1B	8673 4462	11868	-0.068	0.1186	No
165	MAP3K13	22814	11925	-0.070	0.1158	No
166	PDGFRA	16824	11934	-0.070	0.1157	No
167	PRKACA	18549 3844	11953	-0.071	0.1150	No
168	FGFR3	8969 3566	12064	-0.074	0.1093	No
169	PTPRR	3436 19876	12111	-0.076	0.1071	No
170	IL1A	4915	12118	-0.076	0.1071	No
171	NTF3	16991	12174	-0.079	0.1044	No
172	FGF17	21757	12274	-0.083	0.0994	No
173	DUSP10	4003 14016	12469	-0.092	0.0892	No
174	FGF22	12468 7385	12486	-0.093	0.0887	No
175	PLA2G6	22209	12529	-0.094	0.0868	No
176	FGF9	8966	12531	-0.094	0.0871	No
177	NLK	5179 5178	12596	-0.097	0.0840	No
178	EGFR	1329 20944	12619	-0.098	0.0832	No
179	CACNA1C	1158 1166 24464 4463 8674	12628	-0.098	0.0832	No
180	CACNB4	4467	12635	-0.099	0.0833	No
181	FGFR4	3226	12719	-0.103	0.0792	No
182	ELK4	8895 4664 3937	12844	-0.110	0.0729	No
183	MAPK8IP2	77	12884	-0.112	0.0712	No
184	FGF2	15608	13012	-0.120	0.0648	No
185	TGFBR2	2994 3001 10167	13021	-0.120	0.0649	No
186	NGFB	15476	13103	-0.125	0.0610	No
187	CACNA1G	1237 940 20292	13123	-0.126	0.0604	No
188	TGFB3	10161	13186	-0.131	0.0576	No
189	AKT1	8568	13190	-0.131	0.0580	No
190	IL1R1	14264 3987	13402	-0.146	0.0471	No
191	MAPK10	11169	13518	-0.157	0.0415	No
192	DUSP14	12124	14021	-0.209	0.0150	No
193	MAP2K1IP1	12158	14023	-0.209	0.0158	No
194	NTRK1	15299	14033	-0.210	0.0162	No
195	MAPK11	2264 9618 22163	14126	-0.222	0.0121	No
196	MAPT	9420 1347	14129	-0.222	0.0129	No
197	TNFRSF1A	1181 10206	14170	-0.228	0.0117	No
198	RASGRF1	3050 19357	14290	-0.245	0.0062	No
199	PLA2G2F	15700	14522	-0.287	-0.0052	No
200	FGF3	17997	14700	-0.332	-0.0135	No
201	CACNG1	20177	14837	-0.366	-0.0194	No
202	FGF23	17275	14861	-0.373	-0.0191	No
203	DUSP3	1358 13022	14893	-0.381	-0.0193	No
204	RASGRF2	21397	14897	-0.382	-0.0179	No
205	RPS6KA3	8490	14980	-0.408	-0.0206	No
206	DUSP8	9493	15094	-0.452	-0.0249	No
207	CACNA2D2	7154	15095	-0.452	-0.0231	No
208	MAP3K12	6454 11164	15238	-0.509	-0.0287	No
209	ATF2	4418 2759	15372	-0.574	-0.0336	No
210	CACNB1	1443 1304	15399	-0.590	-0.0326	No
211	MAP2K6	20614 1414	15424	-0.607	-0.0315	No
212	RASGRP3	10767	15426	-0.608	-0.0290	No
213	CACNA2D3	8677	15505	-0.655	-0.0306	No
214	MKNK1	2504	15608	-0.715	-0.0332	No
215	MAP2K4	20405	15684	-0.770	-0.0342	No
216	MAP2K2	19933	15807	-0.865	-0.0373	No
217	PTPN5	17817	15838	-0.885	-0.0353	No
218	STMN1	9261	15852	-0.895	-0.0323	No
219	GADD45G	21637	15858	-0.901	-0.0289	No
220	PPP3CA	1863 5284	15979	-0.995	-0.0314	No
221	PPP5C	17952	16344	-1.271	-0.0460	No
222	PAK2	10310 5875	16358	-1.281	-0.0415	No
223	CACNA1S	14111	16389	-1.325	-0.0377	No
224	FLNA	24129	16418	-1.351	-0.0337	No
225	NRAS	5191	16449	-1.395	-0.0296	No
226	MAPK8	6459	16452	-1.403	-0.0240	No
227	TGFB2	5743	16495	-1.457	-0.0204	No
228	IKBKB	4907	16520	-1.483	-0.0156	No
229	ATF4	22417 2239	16551	-1.513	-0.0110	No
230	MAPK12	2182 2215 22164	16618	-1.567	-0.0082	No
231	GADD45B	19935	16692	-1.625	-0.0056	No
232	FLNB	13742	16737	-1.671	-0.0011	No
233	HRAS	4868	16802	-1.753	0.0025	No
234	MAPKAPK3	19003	17096	-2.168	-0.0045	No
235	CHUK	23665	17633	-3.139	-0.0209	No
236	PLA2G12A	1782 7281 1839	18196	-4.948	-0.0312	No
237	MAP4K1	18313	18371	-5.767	-0.0171	No
238	ECSIT	11248	18536	-7.446	0.0044	No