Details for gene set VERHAAK_AML_NPM1_MUT_VS_WT

Table: GSEA Results Summary

Dataset	Set_03_truncNotch_versus_wtNotch.phenotype_truncNotch_versus_wtNotch.cls #wtNotch_versus_truncNotch.phenotype_truncNotch_versus_wtNotch.cls #wtNotch_versus_truncNotch_repos
Phenotype	phenotype_truncNotch_versus_wtNotch.cls#wtNotch_versus_truncNotch_repos
Upregulated in class	truncNotch
GeneSet	VERHAAK_AML_NPM1_MUT_VS_WT_DN
Enrichment Score (ES)	-0.5434037
Normalized Enrichment Score (NES)	-1.6135621
Nominal p-value	0.0
FDR q-value	0.1554414
FWER p-Value	0.958

Table: GSEA details [plain text format]
	PROBE	DESCRIPTION (from dataset)	RANK IN GENE LIST	RANK METRIC SCORE	RUNNING ES	CORE ENRICHMENT
1	POLE	6020538	265	2.398	0.0067	No
2	VIL2	5570161	694	1.755	-0.0011	No
3	ITM2A	460576 4210086	1142	1.289	-0.0140	No
4	EMP1	4120438	1189	1.248	-0.0055	No
5	UGCG	3420053	1230	1.219	0.0030	No
6	H1F0	1400408	1259	1.192	0.0120	No
7	FLNB	2510575	1305	1.148	0.0196	No
8	PPP1R16B	3520300	1379	1.091	0.0253	No
9	DNTT	670162	1605	0.974	0.0216	No
10	WASF1	2060484	1675	0.925	0.0260	No
11	RRAGD	670075	1747	0.879	0.0299	No
12	GATA3	6130068	1785	0.855	0.0354	No
13	RPS6KA2	2970161 4730278	2004	0.726	0.0299	No
14	FOXO1A	3120670	2373	0.553	0.0148	No
15	MX1	2690301 6840364	2434	0.531	0.0162	No
16	RAMP1	2320168	2612	0.467	0.0108	No
17	ABLIM1	580170 3710338 6520504	2619	0.466	0.0145	No
18	ZHX2	2900452	2635	0.461	0.0178	No
19	ALDH2	4230019	2639	0.460	0.0216	No
20	JUP	2510671	2691	0.443	0.0228	No
21	AK3L1	7100601	2922	0.367	0.0135	No
22	CENTD1	2570592	2956	0.354	0.0148	No
23	NEDD4	460736 1190280	3009	0.339	0.0150	No
24	CD69	380167 4730088	3135	0.303	0.0109	No
25	LAMC1	4730025	3306	0.264	0.0040	No
26	ERG	50154 1770739	3309	0.264	0.0062	No
27	ARHGEF17	2060008	3632	0.200	-0.0095	No
28	TCF3	5080022	3817	0.172	-0.0180	No
29	CCR2	1450519	4059	0.140	-0.0298	No
30	MLLT3	510204 3850722 6200088	4097	0.136	-0.0307	No
31	SH3BP4	3140242	4155	0.131	-0.0326	No
32	GATM	380671	4371	0.112	-0.0433	No
33	ITGA6	3830129	4521	0.100	-0.0505	No
34	SPARC	1690086	4765	0.085	-0.0629	No
35	KCNE1L	4670092	4856	0.080	-0.0671	No
36	GALC	2260685 4810161 6370040	4900	0.077	-0.0687	No
37	HGF	3360593	4957	0.075	-0.0711	No
38	TM6SF1	730181	5087	0.069	-0.0775	No
39	MPL	2360253	5133	0.067	-0.0794	No
40	PRKD3	5220520 5890519	5270	0.061	-0.0862	No
41	CD48	1570647	5702	0.045	-0.1092	No
42	PDE4B	4480121	5928	0.039	-0.1211	No
43	GNG7	1940019	6130	0.033	-0.1317	No
44	DHRS3	360609	6168	0.033	-0.1334	No
45	GNAI1	4560390	6354	0.028	-0.1432	No
46	FZD6	360288	6399	0.027	-0.1453	No
47	BPGM	5080520	6567	0.024	-0.1542	No
48	DCHS1	4850487	6656	0.022	-0.1588	No
49	NPR3	1580239	6666	0.021	-0.1591	No
50	FCER1A	1050671	6687	0.021	-0.1600	No
51	PDE3B	2030563	6690	0.021	-0.1599	No
52	NBL1	2480021	6726	0.020	-0.1616	No
53	PAM	5290528	6751	0.020	-0.1627	No
54	DACH1	2450593 5700592	7395	0.008	-0.1975	No
55	MST1	1400403	7424	0.008	-0.1990	No
56	NCAM1	3140026	7611	0.005	-0.2090	No
57	STK32B	7000204	7701	0.003	-0.2139	No
58	CD34	6650270	7744	0.002	-0.2161	No
59	GPSM2	2260053	7849	0.001	-0.2217	No
60	MYH11	7100273	7968	-0.001	-0.2281	No
61	GPA33	2650044	8073	-0.003	-0.2337	No
62	CD38	6100056	8290	-0.006	-0.2454	No
63	CCND2	5340167	8718	-0.014	-0.2685	No
64	F2RL1	3290279	8792	-0.015	-0.2723	No
65	ARHGEF12	3990195	9001	-0.018	-0.2834	No
66	NT5E	2030603 1400731	9044	-0.019	-0.2855	No
67	OPTN	3940041	9046	-0.019	-0.2854	No
68	PTGER4	6400670	9297	-0.023	-0.2988	No
69	AGTPBP1	1990735	9313	-0.024	-0.2994	No
70	TRPM4	6980270	9396	-0.025	-0.3036	No
71	GPM6B	6220458	9490	-0.027	-0.3084	No
72	EPS8	7050204	9559	-0.028	-0.3119	No
73	PMAIP1	1400717 5360047 5900039	9849	-0.033	-0.3273	No
74	GSN	3830168	9994	-0.036	-0.3348	No
75	BANK1	50750	10018	-0.037	-0.3357	No
76	ST18	5720537	10237	-0.041	-0.3471	No
77	ELA2	1570452 5270129	10402	-0.045	-0.3557	No
78	CD19	6940692	10491	-0.046	-0.3600	No
79	CAV1	870025	10632	-0.050	-0.3672	No
80	CSF3R	670500 2640239 3440091 5690020	10774	-0.053	-0.3744	No
81	ROBO1	3710398	10817	-0.054	-0.3762	No
82	ADCY3	2350347 3440242	10956	-0.058	-0.3831	No
83	PPP4R2	5890035	11178	-0.063	-0.3946	No
84	PTRF	2260204	11182	-0.063	-0.3942	No
85	MEF2C	670025 780338	11302	-0.067	-0.4001	No
86	IFI16	6520601	11383	-0.069	-0.4038	No
87	MEST	4780440 6620292	11405	-0.070	-0.4043	No
88	P2RX5	5570427 6130435	11473	-0.072	-0.4073	No
89	SPON1	1660301	11580	-0.075	-0.4124	No
90	TKTL1	2810672 6760102	11943	-0.088	-0.4313	No
91	RHOBTB3	4010687	11962	-0.089	-0.4315	No
92	CLEC5A	6420139	12100	-0.095	-0.4381	No
93	TMOD1	3850100	12119	-0.095	-0.4382	No
94	P2RY5	3800136	12129	-0.096	-0.4379	No
95	LMO4	3800746	12260	-0.101	-0.4440	No
96	POU4F1	2260315	12389	-0.108	-0.4500	No
97	EHD3	5360484	12395	-0.108	-0.4493	No
98	IL5RA	4540091	12469	-0.111	-0.4523	No
99	DPYSL2	2100427 3130112 5700324	12475	-0.112	-0.4516	No
100	RUNX3	3800546	12636	-0.121	-0.4592	No
101	RETN	1050041	12650	-0.121	-0.4589	No
102	CLDN15	4150270 4730592	12755	-0.127	-0.4634	No
103	TSPAN13	1690450	12784	-0.129	-0.4638	No
104	PALM	130601 3850017	12818	-0.131	-0.4644	No
105	FHL1	60278	12986	-0.141	-0.4722	No
106	FGFR1	2190095 4570161	13199	-0.156	-0.4824	No
107	TGFB1I1	2060288 6550450	13285	-0.163	-0.4856	No
108	SLC38A1	520465	13360	-0.168	-0.4881	No
109	TRH	5050576	13408	-0.173	-0.4891	No
110	PTGIR	2100563	13461	-0.177	-0.4904	No
111	RGS1	4060347 4540181	13580	-0.188	-0.4951	No
112	VLDLR	870722 3060047 5340452 6550131	13673	-0.197	-0.4984	No
113	VPREB1	3520280	13725	-0.202	-0.4994	No
114	CYP2E1	4480209	13728	-0.203	-0.4977	No
115	PTPRM	6370136	13776	-0.208	-0.4984	No
116	SYNGR1	5130452 6650056	13845	-0.214	-0.5002	No
117	TFPI	1400288 5550008	13886	-0.218	-0.5005	No
118	EVI1	2000193 2680494	13994	-0.231	-0.5043	No
119	MS4A3	2480309 2690086	14006	-0.233	-0.5028	No
120	B4GALT6	1850176 2340687	14106	-0.243	-0.5061	No
121	MEF2A	2350041 3360128 6040180	14275	-0.266	-0.5128	No
122	APP	2510053	14374	-0.278	-0.5157	No
123	TRAF5	3290064	14379	-0.278	-0.5135	No
124	GJA1	5220731	14454	-0.290	-0.5149	No
125	DEPDC6	730326 5820239	14616	-0.321	-0.5209	No
126	TSPAN7	870133	14621	-0.322	-0.5182	No
127	PROM1	3170537	14670	-0.329	-0.5180	No
128	SPRY1	450253 460093	14805	-0.351	-0.5221	No
129	FGF13	630575 1570440 5360121	14902	-0.371	-0.5241	No
130	SORL1	630204	14932	-0.377	-0.5223	No
131	KIT	7040095	15233	-0.442	-0.5347	No
132	MMP9	580338	15380	-0.483	-0.5384	No
133	BAALC	5310133 6450170	15473	-0.512	-0.5389	Yes
134	ICAM4	6770053	15499	-0.521	-0.5357	Yes
135	TACSTD2	6660341	15518	-0.529	-0.5320	Yes
136	CIITA	2650242	15626	-0.568	-0.5328	Yes
137	TNFRSF21	6380100	15633	-0.570	-0.5281	Yes
138	SERPINE2	2810390	15692	-0.591	-0.5261	Yes
139	HPGD	6770192	15714	-0.599	-0.5219	Yes
140	PLXND1	5270682	15807	-0.631	-0.5214	Yes
141	CD7	3140465	15820	-0.633	-0.5165	Yes
142	ADIPOR1	3140440	15854	-0.644	-0.5126	Yes
143	MSLN	2640048	15868	-0.651	-0.5076	Yes
144	SCRN1	6040025 6580019	16188	-0.791	-0.5179	Yes
145	BZRAP1	5290487	16194	-0.794	-0.5112	Yes
146	DLK1	1240138	16382	-0.888	-0.5136	Yes
147	FZD2	6480154	16540	-0.962	-0.5136	Yes
148	SNCA	5340673	16555	-0.967	-0.5059	Yes
149	IGFBP7	520411 3060110 5290152	16588	-0.984	-0.4990	Yes
150	BLNK	70288 6590092	16674	-1.009	-0.4947	Yes
151	IFITM1	1690601 3120438 6510075	16701	-1.022	-0.4871	Yes
152	EGFL7	150113 670170 3840707	16721	-1.029	-0.4791	Yes
153	HSPG2	2510687 6220750	16727	-1.032	-0.4703	Yes
154	PRTN3	6900670	16734	-1.035	-0.4615	Yes
155	MPO	2360176 2760440 5690176	16754	-1.045	-0.4534	Yes
156	CACNA2D2	520736	16839	-1.086	-0.4484	Yes
157	PTPRCAP	6650075	16872	-1.116	-0.4403	Yes
158	ISG20	1770750	16892	-1.129	-0.4314	Yes
159	YPEL1	6590435	16926	-1.150	-0.4231	Yes
160	SSBP2	2260725 2900400 4730711	16927	-1.151	-0.4130	Yes
161	LCN2	2510112	17048	-1.231	-0.4087	Yes
162	CD3D	2810739	17073	-1.243	-0.3990	Yes
163	TRIB2	4120605	17181	-1.321	-0.3932	Yes
164	NARFL	2260372 4050341	17212	-1.337	-0.3831	Yes
165	CHI3L1	1170039	17254	-1.360	-0.3734	Yes
166	ITM2C	780647	17428	-1.477	-0.3698	Yes
167	ALAS2	6550176	17594	-1.598	-0.3647	Yes
168	SERPINF1	7040367	17622	-1.624	-0.3519	Yes
169	ASS1	1580632 4070082	17662	-1.661	-0.3394	Yes
170	RBPMS	3990494	17716	-1.713	-0.3272	Yes
171	SERPING1	5550440	17774	-1.761	-0.3148	Yes
172	PRODH	1240452	17805	-1.804	-0.3006	Yes
173	HSPB1	6760435	17866	-1.859	-0.2875	Yes
174	CD2	430672	17893	-1.885	-0.2723	Yes
175	HIST1H2BG	5670632	17899	-1.890	-0.2560	Yes
176	GMPR	3990022	18136	-2.160	-0.2498	Yes
177	ATP9A	4780673 5390280	18231	-2.297	-0.2347	Yes
178	LHFPL2	450020	18245	-2.327	-0.2149	Yes
179	CD200	940725 5260647	18269	-2.371	-0.1953	Yes
180	EVL	1740113	18415	-2.713	-0.1793	Yes
181	TGFBI	2060446 6900112	18425	-2.742	-0.1557	Yes
182	ZAP70	1410494 2260504	18495	-2.950	-0.1335	Yes
183	CST7	380369	18501	-2.985	-0.1076	Yes
184	TOX	3440053	18566	-3.421	-0.0809	Yes
185	GYPC	2320102	18596	-4.042	-0.0470	Yes
186	SIDT1	7100010	18614	-5.462	0.0001	Yes