Details for gene set VERHAAK_AML_NPM1_MUT_VS_WT

Table: GSEA Results Summary

Dataset	Set_03_wtNotch_versus_normalThy.phenotype_wtNotch_versus_normalThy.cls #wtNotch_versus_normalThy.phenotype_wtNotch_versus_normalThy.cls #wtNotch_versus_normalThy_repos
Phenotype	phenotype_wtNotch_versus_normalThy.cls#wtNotch_versus_normalThy_repos
Upregulated in class	normalThy
GeneSet	VERHAAK_AML_NPM1_MUT_VS_WT_DN
Enrichment Score (ES)	-0.63315076
Normalized Enrichment Score (NES)	-1.7157422
Nominal p-value	0.0
FDR q-value	0.10594768
FWER p-Value	0.195

Table: GSEA details [plain text format]
	PROBE	DESCRIPTION (from dataset)	RANK IN GENE LIST	RANK METRIC SCORE	RUNNING ES	CORE ENRICHMENT
1	ALDH2	4230019	470	3.002	-0.0102	No
2	HSPB1	6760435	1111	1.896	-0.0352	No
3	ITM2C	780647	1152	1.856	-0.0279	No
4	APP	2510053	1171	1.841	-0.0195	No
5	FLNB	2510575	1180	1.835	-0.0106	No
6	ITM2A	460576 4210086	1271	1.738	-0.0066	No
7	PALM	130601 3850017	1335	1.683	-0.0014	No
8	DLK1	1240138	1399	1.629	0.0035	No
9	ASS1	1580632 4070082	1528	1.508	0.0043	No
10	SLC38A1	520465	1683	1.365	0.0029	No
11	H1F0	1400408	1826	1.248	0.0015	No
12	HSPG2	2510687 6220750	1893	1.192	0.0040	No
13	MX1	2690301 6840364	2073	1.051	-0.0003	No
14	DPYSL2	2100427 3130112 5700324	2183	0.999	-0.0011	No
15	POLE	6020538	2302	0.943	-0.0027	No
16	TGFBI	2060446 6900112	2314	0.934	0.0015	No
17	AK3L1	7100601	2325	0.926	0.0056	No
18	SERPING1	5550440	2475	0.835	0.0018	No
19	CHI3L1	1170039	2655	0.734	-0.0041	No
20	LMO4	3800746	2676	0.723	-0.0015	No
21	RPS6KA2	2970161 4730278	2929	0.602	-0.0121	No
22	RUNX3	3800546	2976	0.583	-0.0117	No
23	TCF3	5080022	3029	0.561	-0.0116	No
24	ATP9A	4780673 5390280	3065	0.550	-0.0107	No
25	PPP1R16B	3520300	3106	0.536	-0.0101	No
26	ZAP70	1410494 2260504	3430	0.417	-0.0255	No
27	GNG7	1940019	3584	0.364	-0.0320	No
28	GYPC	2320102	3591	0.360	-0.0305	No
29	PRKD3	5220520 5890519	3648	0.337	-0.0318	No
30	WASF1	2060484	3673	0.331	-0.0314	No
31	ELA2	1570452 5270129	3704	0.323	-0.0314	No
32	HIST1H2BG	5670632	3792	0.299	-0.0346	No
33	ERG	50154 1770739	3890	0.277	-0.0384	No
34	NEDD4	460736 1190280	3960	0.261	-0.0408	No
35	TNFRSF21	6380100	3992	0.253	-0.0412	No
36	SERPINF1	7040367	4009	0.251	-0.0408	No
37	CAV1	870025	4143	0.228	-0.0469	No
38	MSLN	2640048	4153	0.227	-0.0462	No
39	GALC	2260685 4810161 6370040	4308	0.203	-0.0535	No
40	GSN	3830168	4342	0.200	-0.0543	No
41	CD69	380167 4730088	4356	0.198	-0.0540	No
42	FZD2	6480154	4498	0.179	-0.0607	No
43	OPTN	3940041	4694	0.158	-0.0705	No
44	SERPINE2	2810390	4747	0.154	-0.0725	No
45	PDE3B	2030563	4767	0.152	-0.0728	No
46	B4GALT6	1850176 2340687	4791	0.150	-0.0733	No
47	MPL	2360253	4984	0.133	-0.0830	No
48	NBL1	2480021	4997	0.131	-0.0830	No
49	CSF3R	670500 2640239 3440091 5690020	5085	0.126	-0.0871	No
50	CD48	1570647	5228	0.117	-0.0942	No
51	CCR2	1450519	5326	0.111	-0.0989	No
52	GATM	380671	5389	0.108	-0.1017	No
53	SH3BP4	3140242	5404	0.107	-0.1019	No
54	RBPMS	3990494	5423	0.106	-0.1023	No
55	FCER1A	1050671	5532	0.100	-0.1077	No
56	CD34	6650270	5710	0.091	-0.1168	No
57	FGFR1	2190095 4570161	5852	0.085	-0.1240	No
58	KCNE1L	4670092	6032	0.077	-0.1333	No
59	PTPRM	6370136	6230	0.070	-0.1437	No
60	SYNGR1	5130452 6650056	6414	0.064	-0.1533	No
61	TM6SF1	730181	6507	0.061	-0.1580	No
62	SPARC	1690086	6520	0.060	-0.1583	No
63	PTGER4	6400670	6531	0.060	-0.1585	No
64	ABLIM1	580170 3710338 6520504	6721	0.054	-0.1685	No
65	HGF	3360593	6794	0.052	-0.1722	No
66	P2RY5	3800136	7338	0.040	-0.2014	No
67	MYH11	7100273	7490	0.037	-0.2094	No
68	MEST	4780440 6620292	7679	0.033	-0.2195	No
69	GPA33	2650044	7830	0.031	-0.2274	No
70	ARHGEF12	3990195	7937	0.029	-0.2330	No
71	MST1	1400403	8032	0.027	-0.2380	No
72	ARHGEF17	2060008	8124	0.025	-0.2428	No
73	CLEC5A	6420139	8212	0.023	-0.2474	No
74	EPS8	7050204	8275	0.022	-0.2507	No
75	NPR3	1580239	8413	0.020	-0.2580	No
76	STK32B	7000204	8525	0.018	-0.2639	No
77	ST18	5720537	8661	0.016	-0.2712	No
78	FZD6	360288	8720	0.015	-0.2742	No
79	PTRF	2260204	8885	0.012	-0.2831	No
80	TRH	5050576	9209	0.007	-0.3006	No
81	GNAI1	4560390	9271	0.006	-0.3038	No
82	EVI1	2000193 2680494	9476	0.003	-0.3149	No
83	IFI16	6520601	9778	-0.001	-0.3312	No
84	PPP4R2	5890035	10442	-0.011	-0.3671	No
85	CD19	6940692	10826	-0.017	-0.3878	No
86	GPM6B	6220458	10941	-0.019	-0.3939	No
87	ICAM4	6770053	10982	-0.019	-0.3960	No
88	BANK1	50750	11128	-0.022	-0.4037	No
89	CD38	6100056	11254	-0.024	-0.4104	No
90	BAALC	5310133 6450170	11331	-0.025	-0.4144	No
91	NT5E	2030603 1400731	11384	-0.026	-0.4171	No
92	PAM	5290528	11515	-0.029	-0.4240	No
93	VLDLR	870722 3060047 5340452 6550131	11555	-0.029	-0.4260	No
94	DACH1	2450593 5700592	11576	-0.030	-0.4269	No
95	DCHS1	4850487	11762	-0.034	-0.4368	No
96	TRPM4	6980270	11809	-0.034	-0.4391	No
97	SPON1	1660301	11895	-0.036	-0.4435	No
98	SCRN1	6040025 6580019	11904	-0.036	-0.4438	No
99	GPSM2	2260053	11973	-0.038	-0.4473	No
100	TMOD1	3850100	12023	-0.039	-0.4497	No
101	P2RX5	5570427 6130435	12030	-0.039	-0.4498	No
102	CLDN15	4150270 4730592	12128	-0.041	-0.4549	No
103	MLLT3	510204 3850722 6200088	12171	-0.042	-0.4570	No
104	MEF2C	670025 780338	12428	-0.048	-0.4706	No
105	TKTL1	2810672 6760102	12436	-0.048	-0.4707	No
106	TRAF5	3290064	12480	-0.050	-0.4728	No
107	DHRS3	360609	12782	-0.059	-0.4888	No
108	PROM1	3170537	12823	-0.060	-0.4907	No
109	ROBO1	3710398	12871	-0.062	-0.4929	No
110	PMAIP1	1400717 5360047 5900039	12878	-0.062	-0.4930	No
111	POU4F1	2260315	12887	-0.062	-0.4931	No
112	BLNK	70288 6590092	12888	-0.062	-0.4928	No
113	AGTPBP1	1990735	13454	-0.086	-0.5230	No
114	IL5RA	4540091	13759	-0.104	-0.5389	No
115	PDE4B	4480121	13809	-0.107	-0.5410	No
116	RETN	1050041	14052	-0.125	-0.5535	No
117	TGFB1I1	2060288 6550450	14077	-0.127	-0.5542	No
118	TSPAN7	870133	14264	-0.145	-0.5635	No
119	ZHX2	2900452	14331	-0.152	-0.5663	No
120	CYP2E1	4480209	14387	-0.157	-0.5685	No
121	NCAM1	3140026	14409	-0.160	-0.5689	No
122	CST7	380369	14417	-0.161	-0.5684	No
123	ADCY3	2350347 3440242	14667	-0.190	-0.5810	No
124	MS4A3	2480309 2690086	14705	-0.196	-0.5820	No
125	SPRY1	450253 460093	14773	-0.208	-0.5845	No
126	RGS1	4060347 4540181	14916	-0.238	-0.5910	No
127	RHOBTB3	4010687	14969	-0.252	-0.5926	No
128	F2RL1	3290279	15006	-0.259	-0.5932	No
129	EGFL7	150113 670170 3840707	15131	-0.285	-0.5985	No
130	TSPAN13	1690450	15193	-0.304	-0.6002	No
131	FHL1	60278	15358	-0.356	-0.6073	No
132	TFPI	1400288 5550008	15449	-0.385	-0.6102	No
133	BPGM	5080520	15493	-0.405	-0.6105	No
134	CD2	430672	15811	-0.546	-0.6249	No
135	LHFPL2	450020	15858	-0.572	-0.6245	No
136	MEF2A	2350041 3360128 6040180	16019	-0.660	-0.6298	Yes
137	CD200	940725 5260647	16082	-0.700	-0.6296	Yes
138	CACNA2D2	520736	16124	-0.727	-0.6281	Yes
139	CD7	3140465	16179	-0.758	-0.6271	Yes
140	HPGD	6770192	16184	-0.759	-0.6235	Yes
141	DEPDC6	730326 5820239	16196	-0.767	-0.6202	Yes
142	KIT	7040095	16331	-0.857	-0.6231	Yes
143	SSBP2	2260725 2900400 4730711	16386	-0.891	-0.6214	Yes
144	IFITM1	1690601 3120438 6510075	16588	-1.009	-0.6272	Yes
145	MPO	2360176 2760440 5690176	16666	-1.056	-0.6260	Yes
146	TACSTD2	6660341	16702	-1.089	-0.6223	Yes
147	SNCA	5340673	16715	-1.098	-0.6174	Yes
148	IGFBP7	520411 3060110 5290152	16800	-1.169	-0.6160	Yes
149	CIITA	2650242	16861	-1.212	-0.6130	Yes
150	NARFL	2260372 4050341	16897	-1.244	-0.6086	Yes
151	PTGIR	2100563	17132	-1.521	-0.6135	Yes
152	JUP	2510671	17219	-1.623	-0.6099	Yes
153	YPEL1	6590435	17232	-1.635	-0.6022	Yes
154	FGF13	630575 1570440 5360121	17286	-1.707	-0.5964	Yes
155	PTPRCAP	6650075	17330	-1.759	-0.5897	Yes
156	CENTD1	2570592	17369	-1.819	-0.5825	Yes
157	UGCG	3420053	17501	-2.035	-0.5792	Yes
158	BZRAP1	5290487	17569	-2.155	-0.5718	Yes
159	ITGA6	3830129	17737	-2.489	-0.5682	Yes
160	RAMP1	2320168	17760	-2.546	-0.5564	Yes
161	GATA3	6130068	17768	-2.566	-0.5437	Yes
162	PRTN3	6900670	17834	-2.705	-0.5334	Yes
163	VPREB1	3520280	17844	-2.725	-0.5200	Yes
164	ADIPOR1	3140440	17878	-2.788	-0.5075	Yes
165	RRAGD	670075	17898	-2.843	-0.4941	Yes
166	CD3D	2810739	17940	-2.964	-0.4811	Yes
167	MMP9	580338	18017	-3.118	-0.4694	Yes
168	GJA1	5220731	18083	-3.378	-0.4556	Yes
169	FOXO1A	3120670	18101	-3.422	-0.4391	Yes
170	TRIB2	4120605	18192	-3.802	-0.4246	Yes
171	VIL2	5570161	18197	-3.824	-0.4053	Yes
172	ISG20	1770750	18198	-3.830	-0.3857	Yes
173	EVL	1740113	18214	-3.894	-0.3666	Yes
174	LCN2	2510112	18244	-4.082	-0.3474	Yes
175	ALAS2	6550176	18254	-4.136	-0.3268	Yes
176	EMP1	4120438	18263	-4.181	-0.3058	Yes
177	PLXND1	5270682	18347	-4.646	-0.2866	Yes
178	LAMC1	4730025	18428	-5.358	-0.2636	Yes
179	EHD3	5360484	18447	-5.537	-0.2363	Yes
180	GMPR	3990022	18455	-5.579	-0.2082	Yes
181	SIDT1	7100010	18482	-5.866	-0.1797	Yes
182	SORL1	630204	18493	-5.965	-0.1498	Yes
183	DNTT	670162	18516	-6.384	-0.1184	Yes
184	PRODH	1240452	18555	-7.192	-0.0837	Yes
185	CCND2	5340167	18589	-8.378	-0.0428	Yes
186	TOX	3440053	18599	-8.651	0.0009	Yes