Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | Set_03_absentNotch_versus_wtNotch.phenotype_absentNotch_versus_wtNotch.cls #wtNotch_versus_absentNotch |
| Phenotype | phenotype_absentNotch_versus_wtNotch.cls#wtNotch_versus_absentNotch |
| Upregulated in class | absentNotch |
| GeneSet | REACTOME_IRS_MEDIATED_SIGNALLING |
| Enrichment Score (ES) | -0.7250867 |
| Normalized Enrichment Score (NES) | -1.5596359 |
| Nominal p-value | 0.011741683 |
| FDR q-value | 0.73907554 |
| FWER p-Value | 0.992 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | MAPK3 | 580161 4780035 | 1279 | 0.803 | -0.0053 | No | ||
| 2 | PDE3B | 2030563 | 1905 | 0.562 | 0.0056 | No | ||
| 3 | EEF2K | 3800673 | 2856 | 0.313 | -0.0208 | No | ||
| 4 | SOS1 | 7050338 | 3591 | 0.201 | -0.0444 | No | ||
| 5 | RHEB | 6760441 | 8127 | 0.016 | -0.2870 | No | ||
| 6 | AKT2 | 3850541 3870519 | 8207 | 0.015 | -0.2900 | No | ||
| 7 | EIF4G1 | 4070446 | 8585 | 0.009 | -0.3096 | No | ||
| 8 | PIK3R1 | 4730671 | 8630 | 0.008 | -0.3113 | No | ||
| 9 | MAP2K1 | 840739 | 9684 | -0.006 | -0.3675 | No | ||
| 10 | EIF4EBP1 | 60132 5720148 | 10261 | -0.014 | -0.3973 | No | ||
| 11 | RPS6KB1 | 1450427 5080110 6200563 | 13483 | -0.088 | -0.5636 | No | ||
| 12 | MAPK1 | 3190193 6200253 | 16488 | -0.522 | -0.6839 | Yes | ||
| 13 | EIF4E | 1580403 70133 6380215 | 16676 | -0.587 | -0.6475 | Yes | ||
| 14 | KRAS | 2060170 | 16950 | -0.698 | -0.6070 | Yes | ||
| 15 | MAP2K2 | 4590601 | 17045 | -0.745 | -0.5531 | Yes | ||
| 16 | PIK3CB | 3800600 | 17779 | -1.134 | -0.5029 | Yes | ||
| 17 | PDPK1 | 6650168 | 17818 | -1.163 | -0.4130 | Yes | ||
| 18 | YWHAB | 1740176 | 18339 | -1.729 | -0.3043 | Yes | ||
| 19 | RAF1 | 1770600 | 18428 | -1.946 | -0.1552 | Yes | ||
| 20 | EIF4B | 5390563 5270577 | 18473 | -2.090 | 0.0077 | Yes |
