Details for gene set TGAATGT,MIR-181A,MIR-181B,MIR-181C,MIR-181D[GSEA]

Table: GSEA Results Summary

Dataset	Set_03_truncNotch_versus_wtNotch.phenotype_truncNotch_versus_wtNotch.cls #truncNotch_versus_wtNotch
Phenotype	phenotype_truncNotch_versus_wtNotch.cls#truncNotch_versus_wtNotch
Upregulated in class	wtNotch
GeneSet	TGAATGT,MIR-181A,MIR-181B,MIR-181C,MIR-181D
Enrichment Score (ES)	-0.5282005
Normalized Enrichment Score (NES)	-1.7691935
Nominal p-value	0.0
FDR q-value	0.0067161266
FWER p-Value	0.039

Table: GSEA details [plain text format]
	PROBE	DESCRIPTION (from dataset)	RANK IN GENE LIST	RANK METRIC SCORE	RUNNING ES	CORE ENRICHMENT
1	TOX	3440053	50	3.421	0.0132	No
2	TGFBI	2060446 6900112	191	2.742	0.0184	No
3	B4GALT1	6980167	284	2.483	0.0250	No
4	CARD11	70338	301	2.444	0.0355	No
5	HRB	1660397 6110398	341	2.382	0.0445	No
6	ETV6	610524	460	2.182	0.0482	No
7	BCL2L11	780044 4200601	587	2.033	0.0508	No
8	PLEKHJ1	4050685	1041	1.585	0.0335	No
9	BHLHB2	7040603	1217	1.463	0.0307	No
10	MAP3K3	610685	1290	1.407	0.0334	No
11	AGPAT1	610056	1464	1.298	0.0300	No
12	ANKRD50	870543	1472	1.290	0.0356	No
13	ADM	4810121	1505	1.264	0.0398	No
14	SLC2A3	1990377	1517	1.258	0.0450	No
15	CHD7	3870372	1554	1.238	0.0488	No
16	HYOU1	3060465	1712	1.137	0.0456	No
17	FKBP1A	2450368	1722	1.130	0.0504	No
18	CACNA2D2	520736	1777	1.086	0.0525	No
19	ADRBK1	1340333	1966	1.002	0.0469	No
20	TBC1D1	2510072	1975	1.000	0.0511	No
21	SLC38A2	1470242 3800026	2000	0.995	0.0544	No
22	PIAS3	50204 240739 4060524	2050	0.973	0.0563	No
23	COL16A1	1780520	2051	0.973	0.0609	No
24	HIC2	4010433	2150	0.923	0.0598	No
25	TARDBP	870390 2350093	2164	0.917	0.0634	No
26	CRSP7	4230408	2246	0.877	0.0630	No
27	CRIM1	130491	2530	0.753	0.0511	No
28	PAK4	1690152	2578	0.731	0.0519	No
29	CAMK2G	630097	2653	0.695	0.0511	No
30	CYR61	1240408 5290026 4120452 6550008	2750	0.650	0.0489	No
31	EIF4A2	1170494 1740711 2850504	2866	0.611	0.0455	No
32	MAP3K10	3360168 4850180	3023	0.555	0.0395	No
33	LRP12	2370112	3131	0.517	0.0361	No
34	ETS1	5270278 6450717 6620465	3277	0.470	0.0304	No
35	PCDHA11	1510253	3317	0.459	0.0304	No
36	EGR3	6940128	3418	0.434	0.0269	No
37	PCNP	610768	3422	0.433	0.0288	No
38	MIP	6520333	3462	0.425	0.0286	No
39	EPS15	4200215	3537	0.410	0.0265	No
40	ATXN1	5550156	3574	0.402	0.0264	No
41	FOS	1850315	3645	0.386	0.0244	No
42	GALNTL1	2850497	3893	0.340	0.0125	No
43	DOCK10	5890402 6200279 6770025	3929	0.332	0.0121	No
44	MAP1A	4920576	3945	0.329	0.0128	No
45	ESM1	1410594	3966	0.326	0.0133	No
46	PPP1CB	3130411 3780270 4150180	3979	0.324	0.0141	No
47	CSNK1G1	840082 1230575 3940647	4026	0.316	0.0131	No
48	UNC5A	2120528 3060324	4051	0.312	0.0132	No
49	TBC1D4	6420397	4053	0.312	0.0146	No
50	SPRY4	1570594	4073	0.307	0.0150	No
51	CDYL	4200142 4730397 6060400	4198	0.284	0.0096	No
52	ZBTB4	6450441	4233	0.279	0.0090	No
53	KLHL5	3060484 6400292	4285	0.273	0.0075	No
54	SOX5	2370576 2900167 3190128 5050528	4329	0.268	0.0064	No
55	KLHL2	360551	4360	0.264	0.0060	No
56	PCDHA5	2970347	4473	0.248	0.0010	No
57	GGTL3	1770288	4576	0.235	-0.0035	No
58	MTMR9	2370605	4879	0.203	-0.0190	No
59	PER2	3120204 3390593	5062	0.186	-0.0281	No
60	PHLDA1	2450020	5133	0.179	-0.0311	No
61	BACH2	6760131	5165	0.177	-0.0320	No
62	SYPL2	2450113	5246	0.169	-0.0356	No
63	LIF	1410373 2060129 3990338	5254	0.168	-0.0352	No
64	HOXC8	6220050	5407	0.157	-0.0427	No
65	PCDHA6	780333 2370280	5460	0.153	-0.0449	No
66	CDH13	5130368 5340114	5514	0.149	-0.0471	No
67	ROBO2	450136	5584	0.144	-0.0502	No
68	PKNOX2	610066 2810075 4230601	5706	0.136	-0.0562	No
69	BMPR2	5340066 6960328	5780	0.132	-0.0595	No
70	CPD	5360403 5860685	5802	0.130	-0.0601	No
71	CPNE2	60551	5924	0.123	-0.0661	No
72	IL1A	3610056	6048	0.117	-0.0723	No
73	DPYSL2	2100427 3130112 5700324	6141	0.112	-0.0768	No
74	SYT3	6380017	6164	0.111	-0.0775	No
75	SIX2	1450551	6249	0.107	-0.0816	No
76	HOXB5	2900538	6359	0.101	-0.0871	No
77	RGMA	2450711	6412	0.099	-0.0895	No
78	GRM5	60528	6479	0.096	-0.0926	No
79	CUL5	450142	6527	0.094	-0.0948	No
80	STAG1	1190300 1400722 4590100	6607	0.091	-0.0987	No
81	CNR1	6550494 6760497	6638	0.090	-0.0999	No
82	CNTNAP2	360170 4280546	6796	0.084	-0.1081	No
83	BCL11A	6860369	6966	0.077	-0.1170	No
84	SYNPR	2810400	7086	0.074	-0.1231	No
85	OSBPL8	50603	7110	0.073	-0.1240	No
86	KLF15	4230164	7360	0.066	-0.1373	No
87	SOX6	2940458 4070601 6840717	7362	0.066	-0.1371	No
88	PAK7	3830164	7405	0.064	-0.1391	No
89	TRIM9	1230672 2120162 6450100 6450687	7406	0.064	-0.1388	No
90	TNFRSF11B	4610446	7407	0.064	-0.1385	No
91	BIRC6	70148	7578	0.060	-0.1475	No
92	CDON	540204	7612	0.059	-0.1490	No
93	ARHGEF7	1690441	7815	0.054	-0.1598	No
94	NPTXR	4060685 450438	7867	0.052	-0.1624	No
95	ENAH	1690292 5700300	7869	0.052	-0.1622	No
96	RKHD3	6180471	7935	0.051	-0.1655	No
97	HLF	2370113	7990	0.050	-0.1682	No
98	SUHW4	7000075	8104	0.047	-0.1742	No
99	DOCK7	1780398	8114	0.046	-0.1745	No
100	PCDHA12	2810215	8150	0.046	-0.1762	No
101	LPP	1660541	8155	0.046	-0.1762	No
102	IGSF11	60471 2350288	8170	0.045	-0.1767	No
103	SEPT3	3830022 5290079	8208	0.045	-0.1785	No
104	CBLB	3520465 4670348	8227	0.044	-0.1793	No
105	MAMDC2	430471	8435	0.040	-0.1905	No
106	ADARB1	780451	8481	0.039	-0.1927	No
107	PHOX2B	5270075	8517	0.038	-0.1945	No
108	BAI3	940692	8540	0.038	-0.1955	No
109	FIGN	7000601	8589	0.037	-0.1980	No
110	PRKCE	5700053	8661	0.035	-0.2017	No
111	HOXA11	6980133	8863	0.031	-0.2125	No
112	CDC42BPA	840671	8865	0.031	-0.2124	No
113	GREM1	3940180	8894	0.030	-0.2138	No
114	PCDHA10	3830725	8960	0.029	-0.2172	No
115	TRIM2	430546 1170286	9134	0.027	-0.2266	No
116	ACVR2A	6110647	9148	0.026	-0.2272	No
117	ADAMTS1	3140286 5860463	9190	0.025	-0.2293	No
118	RAB11FIP2	4570040	9565	0.019	-0.2497	No
119	KLF6	110541 5360026	9651	0.018	-0.2542	No
120	MPP5	2100148 5220632	9784	0.015	-0.2614	No
121	LRRN1	3290154	9799	0.015	-0.2621	No
122	GRB10	6980082	9833	0.015	-0.2638	No
123	BTBD3	1980041 2510577 3190053 4200746	9984	0.012	-0.2719	No
124	SCHIP1	4560152	10090	0.010	-0.2776	No
125	ESR1	4060372 5860193	10104	0.010	-0.2783	No
126	TOM1L1	4920056 3190070	10125	0.010	-0.2794	No
127	RPS6KB1	1450427 5080110 6200563	10166	0.009	-0.2815	No
128	NR2C2	6100097	10393	0.005	-0.2938	No
129	CD163	2480315	10413	0.005	-0.2949	No
130	PDGFRA	2940332	10435	0.005	-0.2960	No
131	AKT3	1580270 3290278	10642	0.001	-0.3072	No
132	ZFP36L1	2510138 4120048	10657	0.001	-0.3080	No
133	NMT2	6900148	10757	-0.001	-0.3134	No
134	IMPG1	5570025	10900	-0.003	-0.3212	No
135	WDR37	2630519 6840347	10996	-0.004	-0.3263	No
136	ATG5	6200433 5360324	11032	-0.005	-0.3282	No
137	BAAT	730739	11098	-0.006	-0.3318	No
138	ARNT2	1740594	11133	-0.007	-0.3336	No
139	SMAD7	430377	11203	-0.008	-0.3373	No
140	KCNMA1	1450402	11220	-0.008	-0.3382	No
141	CNTN4	1780300 5570577 6370019	11264	-0.009	-0.3405	No
142	ZIC3	380020	11532	-0.013	-0.3550	No
143	SSX2IP	4610176	11580	-0.014	-0.3575	No
144	ADAMTS18	5690008	11621	-0.015	-0.3596	No
145	PLAG1	1450142 3870139 6520039	11711	-0.017	-0.3644	No
146	RAN	2260446 4590647	11827	-0.019	-0.3706	No
147	PAM	5290528	11865	-0.020	-0.3726	No
148	RBM22	5570064	11882	-0.020	-0.3733	No
149	GABRA1	130372	11912	-0.021	-0.3748	No
150	CCNJ	870047	11944	-0.021	-0.3764	No
151	ZIC2	1410408	11949	-0.021	-0.3765	No
152	GRIK2	4610164	12007	-0.023	-0.3795	No
153	NPEPPS	2630731	12061	-0.024	-0.3823	No
154	E2F5	5860575	12364	-0.031	-0.3987	No
155	SLC25A37	6520341 460471	12376	-0.031	-0.3992	No
156	THRB	1780673	12379	-0.031	-0.3991	No
157	EPHA4	460750	12424	-0.032	-0.4014	No
158	UBE2B	4780497	12482	-0.033	-0.4043	No
159	PLCL2	6100575	12494	-0.034	-0.4048	No
160	TNFSF11	6350204	12548	-0.035	-0.4075	No
161	PCDHA3	3840402	12586	-0.036	-0.4094	No
162	CBX4	70332	12642	-0.038	-0.4122	No
163	TBPL1	3610332	12682	-0.039	-0.4142	No
164	DPP10	4730746	12745	-0.040	-0.4174	No
165	LIN28	6590672	12802	-0.042	-0.4202	No
166	E2F7	4200056	12939	-0.046	-0.4275	No
167	NEGR1	1940731 5130170	13122	-0.053	-0.4372	No
168	ATP2B2	3780397	13151	-0.054	-0.4384	No
169	SLITRK2	2640020	13173	-0.055	-0.4393	No
170	CCNK	6980048	13250	-0.057	-0.4432	No
171	LMO1	3170528	13269	-0.058	-0.4439	No
172	TCERG1	2350551 4540397 5220746	13273	-0.059	-0.4438	No
173	SEMA4C	1980315	13405	-0.063	-0.4507	No
174	OSBPL3	3170164 4210196	13493	-0.067	-0.4551	No
175	USP33	780047	13574	-0.071	-0.4592	No
176	DDX3Y	1580278 4200519	13648	-0.075	-0.4628	No
177	PCDHA1	940026 540484	13707	-0.077	-0.4656	No
178	HECA	3310612	13729	-0.078	-0.4664	No
179	ST8SIA4	2680605 3060215	13771	-0.080	-0.4683	No
180	GRIA2	5080088	13784	-0.081	-0.4686	No
181	EN2	7000368	13806	-0.082	-0.4693	No
182	UBP1	6020707	13826	-0.083	-0.4700	No
183	SLC25A25	1230605	13843	-0.085	-0.4705	No
184	PBX3	1300424 3710577 6180575	13879	-0.086	-0.4720	No
185	PDK4	6400300	13937	-0.090	-0.4747	No
186	HMGB2	2640603	13950	-0.091	-0.4749	No
187	RSBN1	7000487	13951	-0.091	-0.4745	No
188	ANKRD13C	5270202	14091	-0.100	-0.4816	No
189	NRXN1	460408 5340270 6370066	14110	-0.101	-0.4821	No
190	PCGF2	6370347	14171	-0.106	-0.4849	No
191	PALM2	4120068 7100398	14206	-0.109	-0.4863	No
192	SPIRE1	610286 2230142 3120154	14325	-0.120	-0.4922	No
193	NR6A1	4010347	14404	-0.126	-0.4958	No
194	NCOA2	940347 2850725	14441	-0.129	-0.4972	No
195	TRIM3	5570156	14454	-0.130	-0.4973	No
196	MINK1	5860647	14497	-0.135	-0.4989	No
197	NR4A3	2900021 5860095 5910039	14540	-0.138	-0.5006	No
198	QKI	5220093 6130044	14544	-0.139	-0.5001	No
199	ATP11C	770672 7040129	14615	-0.148	-0.5032	No
200	WDR20	1240373	14820	-0.174	-0.5136	No
201	SEMA4G	5890026	14825	-0.176	-0.5130	No
202	ZDHHC7	1500014	14917	-0.189	-0.5171	No
203	BAIAP2	460347 4730600	14951	-0.194	-0.5180	No
204	TRAK2	430736 1770026	15010	-0.204	-0.5202	No
205	SLC9A6	4570091 7100097	15061	-0.212	-0.5219	No
206	CLASP1	6860279	15087	-0.218	-0.5223	No
207	PTPN9	3290408	15099	-0.220	-0.5219	No
208	BAZ2A	730184	15123	-0.226	-0.5221	No
209	ARRDC3	4610390	15141	-0.230	-0.5219	No
210	NLK	2030010 2450041	15161	-0.233	-0.5219	No
211	CAMSAP1	1580131 2120494 6620446	15164	-0.234	-0.5209	No
212	RECK	840079	15173	-0.235	-0.5202	No
213	FNDC3A	2690097 3290044	15178	-0.236	-0.5193	No
214	GATA6	1770010	15179	-0.236	-0.5182	No
215	PICALM	1940280	15187	-0.238	-0.5175	No
216	CARM1	7040292	15188	-0.239	-0.5164	No
217	PSAP	2810338	15205	-0.244	-0.5161	No
218	STC1	360161	15255	-0.253	-0.5176	No
219	HCN2	3840181	15315	-0.265	-0.5196	No
220	CHD9	430037 2570129 5420398	15363	-0.277	-0.5209	No
221	SS18L1	4610180 6550068	15382	-0.281	-0.5206	No
222	LIN7C	4850341	15385	-0.282	-0.5194	No
223	ADAM11	1050008 3130494	15477	-0.302	-0.5229	No
224	PAWR	5130546 6330706	15533	-0.318	-0.5244	No
225	ADCY9	5690168	15548	-0.321	-0.5237	No
226	ARFGEF2	5550500	15631	-0.346	-0.5266	Yes
227	EYA3	1580195 6510632	15636	-0.348	-0.5252	Yes
228	INPP5E	6100619	15645	-0.350	-0.5240	Yes
229	BCLAF1	2030239 5720278	15681	-0.364	-0.5242	Yes
230	INPP5A	5910195	15713	-0.372	-0.5242	Yes
231	CREB1	1500717 2230358 3610600 6550601	15718	-0.374	-0.5226	Yes
232	EN1	5360168 7050025	15795	-0.400	-0.5249	Yes
233	FOXK1	2640373 3290136	15834	-0.411	-0.5251	Yes
234	YTHDF3	4540632 4670717 7040609	15856	-0.421	-0.5243	Yes
235	TIMP3	1450504 1980270	15927	-0.443	-0.5260	Yes
236	PNRC2	3360309	15952	-0.454	-0.5252	Yes
237	SLC25A3	670112	15956	-0.455	-0.5232	Yes
238	PI4K2B	2480215 4610563	15993	-0.464	-0.5230	Yes
239	NARG1	5910563 6350095	16009	-0.469	-0.5217	Yes
240	NCALD	730176	16013	-0.470	-0.5196	Yes
241	NR3C1	630563	16015	-0.470	-0.5175	Yes
242	MAPK1	3190193 6200253	16096	-0.498	-0.5196	Yes
243	CACNB2	1500095 7330707	16139	-0.514	-0.5195	Yes
244	PHF15	6550066 6860673	16156	-0.519	-0.5179	Yes
245	ROD1	2060324 3140332	16208	-0.541	-0.5182	Yes
246	PPP3R1	1190041 1570487	16230	-0.549	-0.5167	Yes
247	MAPT	360706 1230706	16253	-0.557	-0.5153	Yes
248	MAP2K1	840739	16328	-0.587	-0.5167	Yes
249	FOXP1	6510433	16376	-0.605	-0.5164	Yes
250	MYH10	2640673	16399	-0.614	-0.5147	Yes
251	PCDHA7	1850019	16415	-0.622	-0.5127	Yes
252	PUM1	6130500	16425	-0.627	-0.5102	Yes
253	FBXO33	1510504	16499	-0.664	-0.5111	Yes
254	NAT5	1690044 4850242 6110427	16535	-0.679	-0.5098	Yes
255	LRBA	3450402	16551	-0.686	-0.5075	Yes
256	PURB	5360138	16587	-0.701	-0.5061	Yes
257	CAMTA2	3990075	16598	-0.709	-0.5033	Yes
258	ITGA3	4570427	16614	-0.726	-0.5008	Yes
259	SCOC	610048 2230053	16671	-0.761	-0.5003	Yes
260	DYNC1LI2	50338	16678	-0.766	-0.4970	Yes
261	PAPOLG	2470400	16697	-0.776	-0.4944	Yes
262	NFAT5	2510411 5890195 6550152	16745	-0.804	-0.4932	Yes
263	PCAF	2230161 2570369 6550451	16765	-0.812	-0.4904	Yes
264	ZC3H6	130711	16771	-0.817	-0.4869	Yes
265	RTF1	2100735	16773	-0.818	-0.4831	Yes
266	POM121	70152	16803	-0.838	-0.4808	Yes
267	RAD21	1990278	16835	-0.856	-0.4785	Yes
268	TBL1X	6400524	16839	-0.858	-0.4747	Yes
269	SEC24C	6980707	16855	-0.869	-0.4714	Yes
270	MKNK2	1240020 5270092	16879	-0.884	-0.4685	Yes
271	RPS6KA3	1980707	16905	-0.902	-0.4657	Yes
272	MMP14	670079	16996	-0.964	-0.4661	Yes
273	DCUN1D1	2360332	17007	-0.972	-0.4621	Yes
274	MAT2A	4070026 4730079 6020280	17061	-0.995	-0.4604	Yes
275	CGGBP1	4810053	17101	-1.005	-0.4578	Yes
276	ACSL1	2900520	17111	-1.010	-0.4536	Yes
277	RNF34	3800332 4590717 5670138	17118	-1.015	-0.4492	Yes
278	CBX7	3940035	17175	-1.042	-0.4474	Yes
279	PDIA6	2760632	17187	-1.049	-0.4431	Yes
280	DNAJC13	4730091	17225	-1.082	-0.4400	Yes
281	FMNL2	4060438	17286	-1.131	-0.4380	Yes
282	PLEKHA3	5080068	17300	-1.140	-0.4334	Yes
283	SIRT1	1190731	17371	-1.201	-0.4316	Yes
284	CDC73	1580132	17389	-1.222	-0.4269	Yes
285	SFRS7	2760408	17394	-1.224	-0.4214	Yes
286	RAB11A	5360079	17419	-1.242	-0.4169	Yes
287	RANBP5	3780019	17469	-1.283	-0.4136	Yes
288	GOLGA1	5860471	17478	-1.294	-0.4080	Yes
289	RNMT	1770500	17507	-1.327	-0.4033	Yes
290	BRWD1	3130048 3140168 6400601	17582	-1.398	-0.4008	Yes
291	DDX3X	2190020	17667	-1.484	-0.3985	Yes
292	YTHDF2	4060332 4610279	17690	-1.501	-0.3927	Yes
293	PRKCD	770592	17702	-1.525	-0.3862	Yes
294	RUNX1	3840711	17706	-1.531	-0.3792	Yes
295	NSMAF	3870725	17713	-1.543	-0.3723	Yes
296	RKHD2	50035 3930300	17735	-1.564	-0.3661	Yes
297	ATP1B1	3130594	17741	-1.572	-0.3591	Yes
298	YWHAG	3780341	17748	-1.581	-0.3520	Yes
299	RNF6	2640035	17758	-1.588	-0.3451	Yes
300	MECP2	1940450	17781	-1.615	-0.3387	Yes
301	CSNK1G3	110450	17807	-1.640	-0.3324	Yes
302	ILF3	940722 3190647 6520110	17823	-1.657	-0.3255	Yes
303	RBBP7	430113 450450 2370309	17868	-1.701	-0.3200	Yes
304	SENP1	6100537	17960	-1.792	-0.3166	Yes
305	AP1G1	2360671	17963	-1.793	-0.3083	Yes
306	RAP1B	3710138	18017	-1.861	-0.3025	Yes
307	SRPK2	6380341	18036	-1.872	-0.2948	Yes
308	TULP4	2320364	18067	-1.905	-0.2875	Yes
309	GPIAP1	780551 6420079	18087	-1.937	-0.2795	Yes
310	ETF1	6770075	18136	-2.016	-0.2727	Yes
311	CCAR1	3190092	18139	-2.021	-0.2634	Yes
312	DAZAP2	6200102	18149	-2.038	-0.2543	Yes
313	CUL3	1850520	18170	-2.066	-0.2458	Yes
314	EPC2	2470095	18175	-2.073	-0.2363	Yes
315	MBNL2	3450707	18177	-2.076	-0.2267	Yes
316	CTDSPL	4670546	18183	-2.083	-0.2172	Yes
317	IVNS1ABP	4760601 6520113	18205	-2.117	-0.2085	Yes
318	MTPN	3940167	18216	-2.138	-0.1990	Yes
319	SENP2	4540452	18241	-2.179	-0.1902	Yes
320	KPNA1	5270324	18312	-2.308	-0.1832	Yes
321	ATP2A2	1090075 3990279	18452	-2.633	-0.1785	Yes
322	CD4	1090010	18469	-2.701	-0.1668	Yes
323	GHITM	3290092	18480	-2.741	-0.1545	Yes
324	MTMR12	7000181	18485	-2.755	-0.1419	Yes
325	EED	2320373	18492	-2.783	-0.1292	Yes
326	KPNB1	1690138	18506	-2.828	-0.1167	Yes
327	OGT	2360131 4610333	18507	-2.829	-0.1035	Yes
328	RABGEF1	4010497	18523	-2.901	-0.0908	Yes
329	METAP1	3520632	18525	-2.908	-0.0772	Yes
330	UBE3C	3140673	18563	-3.215	-0.0643	Yes
331	WSB1	870563	18567	-3.256	-0.0492	Yes
332	LBR	4540671	18590	-3.582	-0.0337	Yes
333	PIK3R3	1770333	18593	-3.609	-0.0169	Yes
334	BRD1	1660278	18603	-3.884	0.0007	Yes