Details for gene set VERHAAK_AML_NPM1_MUT_VS_WT

Table: GSEA Results Summary

Dataset	Set_03_truncNotch_versus_wtNotch.phenotype_truncNotch_versus_wtNotch.cls #truncNotch_versus_wtNotch
Phenotype	phenotype_truncNotch_versus_wtNotch.cls#truncNotch_versus_wtNotch
Upregulated in class	truncNotch
GeneSet	VERHAAK_AML_NPM1_MUT_VS_WT_DN
Enrichment Score (ES)	0.5434036
Normalized Enrichment Score (NES)	1.598564
Nominal p-value	0.0
FDR q-value	0.16509181
FWER p-Value	0.966

Table: GSEA details [plain text format]
	PROBE	DESCRIPTION (from dataset)	RANK IN GENE LIST	RANK METRIC SCORE	RUNNING ES	CORE ENRICHMENT
1	SIDT1	7100010	2	5.462	0.0479	Yes
2	GYPC	2320102	20	4.042	0.0825	Yes
3	TOX	3440053	50	3.421	0.1110	Yes
4	CST7	380369	115	2.985	0.1338	Yes
5	ZAP70	1410494 2260504	121	2.950	0.1595	Yes
6	TGFBI	2060446 6900112	191	2.742	0.1798	Yes
7	EVL	1740113	201	2.713	0.2032	Yes
8	CD200	940725 5260647	347	2.371	0.2162	Yes
9	LHFPL2	450020	371	2.327	0.2354	Yes
10	ATP9A	4780673 5390280	385	2.297	0.2549	Yes
11	GMPR	3990022	480	2.160	0.2688	Yes
12	HIST1H2BG	5670632	717	1.890	0.2726	Yes
13	CD2	430672	723	1.885	0.2889	Yes
14	HSPB1	6760435	750	1.859	0.3038	Yes
15	PRODH	1240452	811	1.804	0.3164	Yes
16	SERPING1	5550440	842	1.761	0.3303	Yes
17	RBPMS	3990494	900	1.713	0.3422	Yes
18	ASS1	1580632 4070082	954	1.661	0.3540	Yes
19	SERPINF1	7040367	994	1.624	0.3661	Yes
20	ALAS2	6550176	1022	1.598	0.3787	Yes
21	ITM2C	780647	1188	1.477	0.3827	Yes
22	CHI3L1	1170039	1362	1.360	0.3853	Yes
23	NARFL	2260372 4050341	1404	1.337	0.3949	Yes
24	TRIB2	4120605	1435	1.321	0.4048	Yes
25	CD3D	2810739	1543	1.243	0.4100	Yes
26	LCN2	2510112	1568	1.231	0.4195	Yes
27	SSBP2	2260725 2900400 4730711	1689	1.151	0.4231	Yes
28	YPEL1	6590435	1690	1.150	0.4332	Yes
29	ISG20	1770750	1724	1.129	0.4413	Yes
30	PTPRCAP	6650075	1744	1.116	0.4501	Yes
31	CACNA2D2	520736	1777	1.086	0.4579	Yes
32	MPO	2360176 2760440 5690176	1862	1.045	0.4626	Yes
33	PRTN3	6900670	1882	1.035	0.4706	Yes
34	HSPG2	2510687 6220750	1889	1.032	0.4794	Yes
35	EGFL7	150113 670170 3840707	1895	1.029	0.4882	Yes
36	IFITM1	1690601 3120438 6510075	1915	1.022	0.4961	Yes
37	BLNK	70288 6590092	1942	1.009	0.5036	Yes
38	IGFBP7	520411 3060110 5290152	2028	0.984	0.5076	Yes
39	SNCA	5340673	2061	0.967	0.5144	Yes
40	FZD2	6480154	2076	0.962	0.5221	Yes
41	DLK1	1240138	2234	0.888	0.5214	Yes
42	BZRAP1	5290487	2422	0.794	0.5182	Yes
43	SCRN1	6040025 6580019	2428	0.791	0.5249	Yes
44	MSLN	2640048	2748	0.651	0.5133	Yes
45	ADIPOR1	3140440	2762	0.644	0.5183	Yes
46	CD7	3140465	2796	0.633	0.5220	Yes
47	PLXND1	5270682	2809	0.631	0.5269	Yes
48	HPGD	6770192	2902	0.599	0.5272	Yes
49	SERPINE2	2810390	2924	0.591	0.5313	Yes
50	TNFRSF21	6380100	2983	0.570	0.5331	Yes
51	CIITA	2650242	2990	0.568	0.5378	Yes
52	TACSTD2	6660341	3098	0.529	0.5366	Yes
53	ICAM4	6770053	3117	0.521	0.5403	Yes
54	BAALC	5310133 6450170	3143	0.512	0.5434	Yes
55	MMP9	580338	3236	0.483	0.5427	No
56	KIT	7040095	3383	0.442	0.5386	No
57	SORL1	630204	3684	0.377	0.5257	No
58	FGF13	630575 1570440 5360121	3714	0.371	0.5273	No
59	SPRY1	450253 460093	3811	0.351	0.5252	No
60	PROM1	3170537	3946	0.329	0.5209	No
61	TSPAN7	870133	3995	0.322	0.5211	No
62	DEPDC6	730326 5820239	4000	0.321	0.5237	No
63	GJA1	5220731	4162	0.290	0.5175	No
64	TRAF5	3290064	4237	0.278	0.5159	No
65	APP	2510053	4242	0.278	0.5181	No
66	MEF2A	2350041 3360128 6040180	4341	0.266	0.5152	No
67	B4GALT6	1850176 2340687	4510	0.243	0.5082	No
68	MS4A3	2480309 2690086	4610	0.233	0.5049	No
69	EVI1	2000193 2680494	4622	0.231	0.5063	No
70	TFPI	1400288 5550008	4730	0.218	0.5024	No
71	SYNGR1	5130452 6650056	4771	0.214	0.5021	No
72	PTPRM	6370136	4840	0.208	0.5003	No
73	CYP2E1	4480209	4888	0.203	0.4995	No
74	VPREB1	3520280	4891	0.202	0.5012	No
75	VLDLR	870722 3060047 5340452 6550131	4943	0.197	0.5001	No
76	RGS1	4060347 4540181	5036	0.188	0.4968	No
77	PTGIR	2100563	5155	0.177	0.4919	No
78	TRH	5050576	5208	0.173	0.4906	No
79	SLC38A1	520465	5256	0.168	0.4896	No
80	TGFB1I1	2060288 6550450	5331	0.163	0.4870	No
81	FGFR1	2190095 4570161	5417	0.156	0.4838	No
82	FHL1	60278	5630	0.141	0.4735	No
83	PALM	130601 3850017	5798	0.131	0.4656	No
84	TSPAN13	1690450	5832	0.129	0.4649	No
85	CLDN15	4150270 4730592	5861	0.127	0.4645	No
86	RETN	1050041	5966	0.121	0.4599	No
87	RUNX3	3800546	5980	0.121	0.4603	No
88	DPYSL2	2100427 3130112 5700324	6141	0.112	0.4526	No
89	IL5RA	4540091	6147	0.111	0.4533	No
90	EHD3	5360484	6221	0.108	0.4503	No
91	POU4F1	2260315	6227	0.108	0.4510	No
92	LMO4	3800746	6356	0.101	0.4449	No
93	P2RY5	3800136	6487	0.096	0.4387	No
94	TMOD1	3850100	6497	0.095	0.4390	No
95	CLEC5A	6420139	6516	0.095	0.4389	No
96	RHOBTB3	4010687	6654	0.089	0.4322	No
97	TKTL1	2810672 6760102	6673	0.088	0.4320	No
98	SPON1	1660301	7036	0.075	0.4131	No
99	P2RX5	5570427 6130435	7143	0.072	0.4079	No
100	MEST	4780440 6620292	7211	0.070	0.4049	No
101	IFI16	6520601	7233	0.069	0.4044	No
102	MEF2C	670025 780338	7314	0.067	0.4006	No
103	PTRF	2260204	7434	0.063	0.3947	No
104	PPP4R2	5890035	7438	0.063	0.3951	No
105	ADCY3	2350347 3440242	7660	0.058	0.3837	No
106	ROBO1	3710398	7799	0.054	0.3766	No
107	CSF3R	670500 2640239 3440091 5690020	7842	0.053	0.3748	No
108	CAV1	870025	7984	0.050	0.3676	No
109	CD19	6940692	8125	0.046	0.3604	No
110	ELA2	1570452 5270129	8214	0.045	0.3560	No
111	ST18	5720537	8379	0.041	0.3475	No
112	BANK1	50750	8598	0.037	0.3360	No
113	GSN	3830168	8622	0.036	0.3351	No
114	PMAIP1	1400717 5360047 5900039	8767	0.033	0.3275	No
115	EPS8	7050204	9057	0.028	0.3121	No
116	GPM6B	6220458	9126	0.027	0.3087	No
117	TRPM4	6980270	9220	0.025	0.3038	No
118	AGTPBP1	1990735	9303	0.024	0.2996	No
119	PTGER4	6400670	9319	0.023	0.2990	No
120	OPTN	3940041	9570	0.019	0.2856	No
121	NT5E	2030603 1400731	9572	0.019	0.2857	No
122	ARHGEF12	3990195	9615	0.018	0.2836	No
123	F2RL1	3290279	9824	0.015	0.2724	No
124	CCND2	5340167	9898	0.014	0.2686	No
125	CD38	6100056	10326	0.006	0.2455	No
126	GPA33	2650044	10543	0.003	0.2338	No
127	MYH11	7100273	10648	0.001	0.2281	No
128	GPSM2	2260053	10767	-0.001	0.2218	No
129	CD34	6650270	10872	-0.002	0.2161	No
130	STK32B	7000204	10915	-0.003	0.2139	No
131	NCAM1	3140026	11005	-0.005	0.2091	No
132	MST1	1400403	11192	-0.008	0.1991	No
133	DACH1	2450593 5700592	11221	-0.008	0.1976	No
134	PAM	5290528	11865	-0.020	0.1629	No
135	NBL1	2480021	11890	-0.020	0.1618	No
136	PDE3B	2030563	11926	-0.021	0.1601	No
137	FCER1A	1050671	11929	-0.021	0.1601	No
138	NPR3	1580239	11950	-0.021	0.1593	No
139	DCHS1	4850487	11960	-0.022	0.1590	No
140	BPGM	5080520	12049	-0.024	0.1544	No
141	FZD6	360288	12217	-0.027	0.1456	No
142	GNAI1	4560390	12262	-0.028	0.1434	No
143	DHRS3	360609	12448	-0.033	0.1337	No
144	GNG7	1940019	12486	-0.033	0.1320	No
145	PDE4B	4480121	12688	-0.039	0.1214	No
146	CD48	1570647	12914	-0.045	0.1096	No
147	PRKD3	5220520 5890519	13346	-0.061	0.0867	No
148	MPL	2360253	13483	-0.067	0.0800	No
149	TM6SF1	730181	13529	-0.069	0.0781	No
150	HGF	3360593	13659	-0.075	0.0718	No
151	GALC	2260685 4810161 6370040	13716	-0.077	0.0694	No
152	KCNE1L	4670092	13760	-0.080	0.0678	No
153	SPARC	1690086	13851	-0.085	0.0637	No
154	ITGA6	3830129	14095	-0.100	0.0514	No
155	GATM	380671	14245	-0.112	0.0443	No
156	SH3BP4	3140242	14461	-0.131	0.0337	No
157	MLLT3	510204 3850722 6200088	14519	-0.136	0.0319	No
158	CCR2	1450519	14557	-0.140	0.0311	No
159	TCF3	5080022	14799	-0.172	0.0195	No
160	ARHGEF17	2060008	14984	-0.200	0.0113	No
161	ERG	50154 1770739	15307	-0.264	-0.0039	No
162	LAMC1	4730025	15310	-0.264	-0.0017	No
163	CD69	380167 4730088	15481	-0.303	-0.0082	No
164	NEDD4	460736 1190280	15607	-0.339	-0.0120	No
165	CENTD1	2570592	15660	-0.354	-0.0117	No
166	AK3L1	7100601	15694	-0.367	-0.0103	No
167	JUP	2510671	15925	-0.443	-0.0189	No
168	ALDH2	4230019	15977	-0.460	-0.0176	No
169	ZHX2	2900452	15981	-0.461	-0.0137	No
170	ABLIM1	580170 3710338 6520504	15997	-0.466	-0.0104	No
171	RAMP1	2320168	16004	-0.467	-0.0066	No
172	MX1	2690301 6840364	16182	-0.531	-0.0116	No
173	FOXO1A	3120670	16243	-0.553	-0.0100	No
174	RPS6KA2	2970161 4730278	16612	-0.726	-0.0236	No
175	GATA3	6130068	16831	-0.855	-0.0279	No
176	RRAGD	670075	16869	-0.879	-0.0221	No
177	WASF1	2060484	16941	-0.925	-0.0179	No
178	DNTT	670162	17011	-0.974	-0.0131	No
179	PPP1R16B	3520300	17237	-1.091	-0.0157	No
180	FLNB	2510575	17311	-1.148	-0.0095	No
181	H1F0	1400408	17357	-1.192	-0.0015	No
182	UGCG	3420053	17386	-1.219	0.0077	No
183	EMP1	4120438	17427	-1.248	0.0165	No
184	ITM2A	460576 4210086	17474	-1.289	0.0253	No
185	VIL2	5570161	17922	-1.755	0.0165	No
186	POLE	6020538	18351	-2.398	0.0144	No