Details for gene set VERHAAK_AML_NPM1_MUT_VS_WT

Table: GSEA Results Summary

Dataset	Set_01_SCID_versus_ATM_plus.phenotype_SCID_versus_ATM_plus.cls #SCID_versus_ATM_plus.phenotype_SCID_versus_ATM_plus.cls #SCID_versus_ATM_plus_repos
Phenotype	phenotype_SCID_versus_ATM_plus.cls#SCID_versus_ATM_plus_repos
Upregulated in class	ATM_plus
GeneSet	VERHAAK_AML_NPM1_MUT_VS_WT_DN
Enrichment Score (ES)	-0.4870413
Normalized Enrichment Score (NES)	-1.9322357
Nominal p-value	0.0
FDR q-value	0.012070375
FWER p-Value	0.184

Table: GSEA details [plain text format]
	PROBE	DESCRIPTION (from dataset)	RANK IN GENE LIST	RANK METRIC SCORE	RUNNING ES	CORE ENRICHMENT
1	ASS1	1416239_at 1459937_at	22	7.949	0.0249	No
2	TSPAN7	1417502_at 1448737_at 1459812_x_at	52	7.558	0.0481	No
3	KIT	1415900_a_at 1452514_a_at 1459588_at	820	2.727	0.0217	No
4	GALC	1420547_at 1449900_at 1452907_at	938	2.531	0.0246	No
5	CST7	1419202_at 1445263_at	1271	2.150	0.0163	No
6	MX1	1451905_a_at	1408	2.049	0.0167	No
7	ATP9A	1415932_x_at 1425838_at 1427604_a_at	1411	2.049	0.0233	No
8	HSPG2	1418669_at 1418670_s_at	1454	2.022	0.0279	No
9	POLE	1441854_at 1448650_a_at	1491	2.004	0.0328	No
10	GNG7	1455190_at	1699	1.901	0.0295	No
11	SERPINE2	1416666_at	1993	1.733	0.0216	No
12	TKTL1	1420064_s_at 1420065_at 1449567_at	2055	1.695	0.0243	No
13	H1F0	1423702_at 1450522_a_at	2146	1.649	0.0256	No
14	NPR3	1435184_at 1448024_at 1450286_at	2204	1.617	0.0282	No
15	MTMR11	1435294_at 1441835_x_at 1460550_at	2338	1.548	0.0271	No
16	TPSAB1	1426175_a_at	2431	1.509	0.0278	No
17	DLK1	1449939_s_at	2579	1.442	0.0257	No
18	BZRAP1	1455771_at	2770	1.381	0.0215	No
19	RAP2A	1421574_at 1426965_at 1440473_at	2993	1.314	0.0155	No
20	TOX	1425483_at 1425484_at 1442039_at 1446950_at 1458974_at	3115	1.277	0.0141	No
21	PALM	1422034_a_at 1423967_at 1439927_at 1457217_at	3134	1.272	0.0174	No
22	TNFRSF21	1422740_at 1450731_s_at	3218	1.251	0.0177	No
23	MEF2A	1421252_a_at 1425426_a_at 1427185_at 1427186_a_at 1452347_at	3313	1.230	0.0174	No
24	UGCG	1421268_at 1421269_at 1435133_at 1439863_at	3350	1.222	0.0197	No
25	MPL	1421461_at 1451919_a_at	3418	1.208	0.0206	No
26	ARHGEF17	1419938_s_at 1419939_at 1433682_at 1442357_at 1447441_at	3749	1.140	0.0091	No
27	PXDN	1428259_at	3922	1.111	0.0048	No
28	SERPINF1	1416168_at 1453724_a_at	4065	1.084	0.0018	No
29	MS4A3	1420572_at	4083	1.080	0.0045	No
30	SPON1	1424415_s_at 1441226_at 1451342_at	4273	1.050	-0.0008	No
31	GNAI1	1427510_at 1434440_at 1454959_s_at	4341	1.041	-0.0005	No
32	LMO4	1420981_a_at 1439651_at	4400	1.032	0.0002	No
33	IGFBP7	1423584_at 1437804_at	4469	1.024	0.0004	No
34	MEF2C	1421027_a_at 1421028_a_at 1424852_at 1439946_at 1445420_at 1446484_at 1451506_at 1451507_at 1458551_at	4473	1.023	0.0036	No
35	DPYSL2	1433770_at 1450502_at 1458188_at 1458632_at	4572	1.013	0.0024	No
36	DCHS1	1429163_at	4694	1.001	0.0001	No
37	TRIB2	1426640_s_at 1426641_at 1459852_x_at	4714	0.999	0.0025	No
38	ARHGEF12	1423902_s_at 1446965_at 1451159_at 1453853_a_at	4804	0.989	0.0016	No
39	TFPI	1438530_at 1451790_a_at 1451791_at 1452432_at	4853	0.982	0.0026	No
40	FLNB	1424828_a_at 1426750_at 1442107_at 1445534_at 1458226_at	4997	0.966	-0.0008	No
41	RUNX3	1421467_at 1440275_at	5034	0.961	0.0006	No
42	MMP9	1416298_at 1448291_at	5171	0.941	-0.0026	No
43	GYPC	1423878_at	5176	0.941	0.0003	No
44	HGF	1425379_at 1442884_at 1451866_a_at	5189	0.939	0.0028	No
45	SCRN1	1428717_at 1428718_at	5208	0.935	0.0050	No
46	P2RX5	1449433_at	5670	0.874	-0.0133	No
47	EMP1	1416529_at 1459171_at	5909	0.842	-0.0215	No
48	CACNA2D2	1426185_at	5921	0.841	-0.0193	No
49	PROM1	1419700_a_at	6194	0.805	-0.0292	No
50	SYNGR1	1419289_a_at 1434661_at 1453772_at	6282	0.795	-0.0306	No
51	CYP2E1	1415994_at	6549	0.762	-0.0404	No
52	CIITA	1421210_at 1421211_a_at 1447075_at	6576	0.759	-0.0391	No
53	AGTPBP1	1429933_at 1432385_a_at	7107	0.698	-0.0612	No
54	NBL1	1448428_at	7122	0.696	-0.0596	No
55	BAIAP3	1427509_at	7130	0.696	-0.0577	No
56	EGFL7	1421335_a_at 1435823_x_at 1451427_a_at 1451428_x_at	7361	0.667	-0.0661	No
57	MYH11	1418122_at 1448962_at	7383	0.665	-0.0649	No
58	APP	1420621_a_at 1427442_a_at 1438373_at 1438374_x_at 1444705_at 1447347_at 1458525_at	7461	0.655	-0.0663	No
59	CLEC5A	1421366_at	7473	0.654	-0.0647	No
60	RPS6KA2	1417542_at 1417543_at 1441311_at	7640	0.637	-0.0702	No
61	SERPING1	1416625_at	7933	0.607	-0.0817	No
62	AK3L1	1421829_at 1421830_at 1450387_s_at	7997	0.600	-0.0826	No
63	FCER1A	1421775_at	8148	0.585	-0.0876	No
64	MST1	1418267_at	8382	0.562	-0.0965	No
65	PTRF	1421431_at 1424130_a_at 1453891_at	8660	0.534	-0.1075	No
66	SNCA	1418493_a_at 1431022_at 1436853_a_at 1446391_at	9069	0.493	-0.1247	No
67	GPSM2	1424895_at	9189	0.481	-0.1286	No
68	FHL1	1417872_at 1459003_at	9442	0.457	-0.1387	No
69	RHOBTB3	1429661_at 1433647_s_at 1447869_x_at 1453227_at 1457009_at	9448	0.457	-0.1375	No
70	MN1	1454867_at	9590	0.441	-0.1425	No
71	RETN	1449182_at	9827	0.419	-0.1520	No
72	IL5RA	1421620_at	9850	0.417	-0.1517	No
73	GPA33	1419330_a_at 1454247_a_at	9935	0.408	-0.1542	No
74	RUNX1T1	1427640_a_at 1437784_at 1440310_at 1443788_at 1444615_x_at 1444904_at 1448785_at	10175	0.385	-0.1639	No
75	TCF3	1436207_at 1450117_at	10239	0.379	-0.1656	No
76	P2RY5	1428615_at 1444627_at	10367	0.368	-0.1702	No
77	TRH	1418756_at	10937	0.313	-0.1954	No
78	LRP3	1436083_at	11044	0.304	-0.1993	No
79	MSLN	1460238_at	11056	0.303	-0.1988	No
80	TGFB1I1	1418136_at	11076	0.302	-0.1987	No
81	ERG	1425370_a_at 1440244_at	11523	0.258	-0.2184	No
82	DACH1	1420694_a_at 1420695_at 1433743_at 1447174_at 1459381_at	11669	0.242	-0.2243	No
83	BLNK	1451780_at	11797	0.229	-0.2294	No
84	CCR2	1421186_at 1421187_at 1421188_at 1460067_at	11984	0.210	-0.2372	No
85	TMOD1	1419863_at 1422754_at	11998	0.208	-0.2372	No
86	FGFR1	1424050_s_at 1425911_a_at 1436551_at	12054	0.204	-0.2390	No
87	ZAP70	1422701_at 1439749_at 1440178_x_at	12793	0.138	-0.2725	No
88	EVI1	1423011_at 1438325_at	12843	0.132	-0.2744	No
89	LHFPL2	1434129_s_at 1434130_at 1443185_at 1454847_at	12866	0.129	-0.2749	No
90	ST18	1436793_at 1455123_at	12940	0.122	-0.2779	No
91	MEST	1423294_at	13253	0.087	-0.2920	No
92	VLDLR	1417900_a_at 1434465_x_at 1435893_at 1438258_at 1442169_at 1451156_s_at	13272	0.085	-0.2925	No
93	B4GALT6	1441169_at	13282	0.083	-0.2927	No
94	CAV1	1449145_a_at	13411	0.070	-0.2983	No
95	ALDH2	1434987_at 1434988_x_at 1437410_at 1448143_at	13489	0.061	-0.3017	No
96	EPS8	1422823_at 1422824_s_at 1425733_a_at 1436977_at	13587	0.050	-0.3060	No
97	SART2	1455795_at	13673	0.042	-0.3098	No
98	ROBO1	1427231_at 1443042_at 1457407_at 1459453_at	13676	0.042	-0.3097	No
99	POU4F1	1429667_at 1429668_at	13756	0.033	-0.3132	No
100	NARFL	1450452_a_at	13789	0.029	-0.3146	No
101	BAALC	1426329_s_at 1430649_at 1436878_at 1452022_at	13807	0.027	-0.3153	No
102	NRXN2	1435907_at 1435908_at 1455499_at	14039	0.003	-0.3259	No
103	F2RL1	1448931_at	14169	-0.013	-0.3318	No
104	WASF1	1418545_at 1440438_at	14215	-0.017	-0.3338	No
105	CLDN15	1418920_at	14246	-0.021	-0.3352	No
106	SPRY1	1415874_at	14537	-0.058	-0.3483	No
107	ITM2C	1415961_at	14547	-0.059	-0.3485	No
108	FZD6	1417301_at 1448662_at 1458904_at	14607	-0.066	-0.3510	No
109	NT5E	1416517_at 1422974_at 1427379_at 1428547_at	14639	-0.070	-0.3522	No
110	CD19	1450570_a_at	14726	-0.083	-0.3559	No
111	HPGD	1419905_s_at 1419906_at	14784	-0.089	-0.3582	No
112	RGS1	1417601_at	14869	-0.100	-0.3618	No
113	CD34	1416072_at	15048	-0.124	-0.3696	No
114	SCCPDH	1426510_at 1438909_at	15177	-0.140	-0.3750	No
115	TRPM4	1435549_at	15304	-0.159	-0.3803	No
116	PTPRM	1422541_at 1441199_at	15720	-0.221	-0.3987	No
117	FAIM3	1429889_at	15831	-0.239	-0.4029	No
118	RBPMS	1425652_s_at 1429359_s_at 1437161_x_at 1444765_at 1455936_a_at 1459078_at	15844	-0.241	-0.4027	No
119	SLC38A1	1415903_at 1454764_s_at	15849	-0.242	-0.4021	No
120	FZD2	1418532_at 1418533_s_at	15934	-0.261	-0.4051	No
121	SNRPN /// SNURF	1421063_s_at	15958	-0.266	-0.4053	No
122	NCAM1	1421966_at 1425126_at 1426864_a_at 1426865_a_at 1439556_at 1440067_at 1441995_at 1442680_at 1443018_at 1450437_a_at 1450438_at 1454140_at	16044	-0.280	-0.4083	No
123	BANK1	1442646_at 1456328_at	16204	-0.310	-0.4146	No
124	ICAM4	1422930_at	16220	-0.313	-0.4143	No
125	GATM	1423569_at	16274	-0.325	-0.4157	No
126	DEPDC6	1419963_at 1428622_at 1443579_s_at 1446254_at 1451348_at 1453571_at 1459719_at	16409	-0.350	-0.4207	No
127	ADCY3	1421959_s_at 1421960_at 1436928_s_at 1436929_x_at 1440405_at 1444641_at	16444	-0.358	-0.4211	No
128	STK32B	1431236_at 1452420_at	16505	-0.370	-0.4227	No
129	YPEL1	1421048_a_at 1431781_at 1431782_s_at 1442660_at	16571	-0.385	-0.4244	No
130	CD38	1433741_at 1450136_at	16624	-0.398	-0.4255	No
131	CSF3R	1418806_at	16734	-0.430	-0.4291	No
132	KCNE1L	1416640_at	16882	-0.466	-0.4344	No
133	OPTN	1429778_at 1435679_at	16943	-0.481	-0.4356	No
134	IFITM1	1424254_at	17040	-0.504	-0.4383	No
135	TACSTD2	1423323_at	17111	-0.524	-0.4398	No
136	SH3BP4	1416305_at 1455250_at	17135	-0.529	-0.4392	No
137	GJA1	1415800_at 1415801_at 1437992_x_at 1438650_x_at 1438945_x_at 1438973_x_at	17261	-0.570	-0.4431	No
138	CENTD1	1436895_at 1446649_at 1452291_at 1456337_at 1458173_at	17442	-0.621	-0.4493	No
139	FOXO1A	1416981_at 1416982_at 1416983_s_at 1459170_at	17552	-0.660	-0.4522	No
140	C1ORF24	1422567_at 1454942_at	17582	-0.669	-0.4514	No
141	PTGIR	1427313_at	17737	-0.710	-0.4561	No
142	DSU	1437250_at	17818	-0.742	-0.4574	No
143	ITGA6	1422444_at 1422445_at	18008	-0.808	-0.4635	No
144	PMAIP1	1418203_at	18072	-0.835	-0.4636	No
145	ENDOD1	1426540_at 1426541_a_at 1426542_at 1426543_x_at 1433796_at	18148	-0.864	-0.4643	No
146	IFI44	1423555_a_at	18215	-0.886	-0.4644	No
147	HSPB1	1422943_a_at 1425964_x_at 1427853_a_at 1427854_x_at 1453914_at	18292	-0.911	-0.4650	No
148	PRKD3	1420567_at 1428229_at 1428230_at 1444691_at	18552	-0.994	-0.4736	No
149	RRAGD	1431164_at 1434909_at 1440555_at	18707	-1.040	-0.4773	No
150	CHI3L1	1451537_at	18875	-1.110	-0.4814	Yes
151	BPGM	1415864_at 1415865_s_at 1448119_at	18897	-1.119	-0.4787	Yes
152	ELA2	1422928_at	18910	-1.124	-0.4756	Yes
153	FGF13	1418497_at 1418498_at	19002	-1.169	-0.4760	Yes
154	GPM6B	1423091_a_at 1425942_a_at 1453514_at	19201	-1.263	-0.4810	Yes
155	MLLT3	1429205_at 1431890_a_at 1441535_at 1453622_s_at	19252	-1.293	-0.4791	Yes
156	VIL2	1450850_at 1456725_x_at	19287	-1.312	-0.4764	Yes
157	CD48	1427301_at	19435	-1.398	-0.4786	Yes
158	PAM	1418908_at 1445797_at	19450	-1.409	-0.4747	Yes
159	PTPRCAP	1448511_at	19621	-1.514	-0.4776	Yes
160	VEGF	1420909_at 1451959_a_at	19669	-1.555	-0.4747	Yes
161	TM6SF1	1451353_at	19938	-1.754	-0.4813	Yes
162	LAMC1	1423885_at 1423886_at	20064	-1.855	-0.4810	Yes
163	RAMP1	1417481_at 1447474_at	20122	-1.899	-0.4774	Yes
164	PPP1R16B	1425414_at 1455080_at	20187	-1.959	-0.4740	Yes
165	VPREB1	1449869_at	20202	-1.969	-0.4682	Yes
166	GSN	1415812_at 1436991_x_at 1437171_x_at 1441225_at 1456312_x_at 1456568_at 1456569_x_at	20219	-1.981	-0.4625	Yes
167	SPARC	1416589_at 1448392_at 1458204_at	20272	-2.010	-0.4584	Yes
168	PTGER4	1421073_a_at 1424208_at 1436441_at	20389	-2.086	-0.4569	Yes
169	CD200	1448788_at 1458082_at	20641	-2.382	-0.4607	Yes
170	GMPR	1448530_at	20643	-2.383	-0.4530	Yes
171	TSPAN13	1418643_at 1460239_at	20790	-2.562	-0.4514	Yes
172	MDFIC	1427040_at	20842	-2.645	-0.4451	Yes
173	DNTT	1420166_at 1449757_x_at 1450545_a_at	20863	-2.683	-0.4373	Yes
174	TGFBI	1415871_at 1437463_x_at 1448123_s_at 1456250_x_at	20889	-2.720	-0.4296	Yes
175	PPP4R2	1433851_at 1442834_at	20949	-2.801	-0.4232	Yes
176	PDE3B	1433694_at	20971	-2.853	-0.4149	Yes
177	SERINC5	1433571_at	21101	-3.129	-0.4106	Yes
178	SORL1	1426258_at 1445889_at 1453003_at 1460390_at	21122	-3.162	-0.4013	Yes
179	SIDT1	1426550_at 1426551_at	21258	-3.519	-0.3960	Yes
180	PRTN3	1419669_at	21264	-3.531	-0.3848	Yes
181	ZHX2	1455210_at	21272	-3.557	-0.3735	Yes
182	MPO	1415960_at	21304	-3.651	-0.3630	Yes
183	GATA3	1448886_at	21331	-3.739	-0.3521	Yes
184	SPIB	1460407_at	21336	-3.766	-0.3400	Yes
185	ALAS2	1451675_a_at	21415	-4.037	-0.3304	Yes
186	DHRS3	1448390_a_at	21429	-4.091	-0.3177	Yes
187	SSBP2	1429951_at 1438423_at 1449815_a_at 1451542_at	21486	-4.320	-0.3062	Yes
188	NEDD4	1421955_a_at 1444044_at 1450431_a_at 1451109_a_at	21487	-4.321	-0.2922	Yes
189	CD3D	1422828_at	21560	-4.763	-0.2800	Yes
190	CD69	1428735_at	21570	-4.845	-0.2646	Yes
191	JUP	1426873_s_at	21633	-5.336	-0.2501	Yes
192	CD7	1419711_at	21644	-5.423	-0.2329	Yes
193	LCN2	1427747_a_at	21666	-5.583	-0.2157	Yes
194	ABLIM1	1442376_at 1453103_at 1454708_at 1460120_at	21696	-5.811	-0.1981	Yes
195	CD2	1418770_at	21715	-6.027	-0.1793	Yes
196	EHD3	1417235_at 1417236_at	21721	-6.095	-0.1597	Yes
197	ISG20	1419569_a_at	21753	-6.425	-0.1402	Yes
198	PLXND1	1451475_at	21814	-7.199	-0.1196	Yes
199	ITM2A	1423608_at 1451047_at	21840	-7.488	-0.0963	Yes
200	ADIPOR1	1424312_at 1439017_x_at 1451311_a_at	21855	-7.652	-0.0721	Yes
201	CCND2	1416122_at 1416123_at 1416124_at 1430127_a_at 1434745_at 1448229_s_at 1455956_x_at	21869	-7.737	-0.0475	Yes
202	PDE4B	1422473_at 1422474_at 1442700_at 1444731_at 1445449_at 1446577_at 1447237_at 1447718_at	21873	-7.745	-0.0224	Yes
203	EVL	1434920_a_at 1440885_at 1445957_at 1450106_a_at 1456453_at 1458889_at	21877	-7.764	0.0027	Yes