• Resource: panther/Insulin_IGF_pathway-protein_kinase_B_signaling_cascade.owl; different types of problem: 13
    • number of pathways : 7  number of physical entities : 48  number of genes : 0  number of interactions : 43 
    • auto-fix: true; normalize:
    • errors/warnings: 163 - not fixed: 139;  errors not fixed: 13
    • Modified BioPAX  ("escaped" RDF in HTML; choose BioPAX or XML as return if you plan to process it)
    • ERROR: cardinality.violated , category: SPECIFICATION,  cases: 8,  not fixed: 8
      Cardinality violation
      • object: DISSOCIATION
        property: db requires exactly 1 value(s)
        (found by: org.biopax.validator.rules.XrefDbCRRule)
      • object: HETERODIMER_ASSOCIATION
        property: db requires exactly 1 value(s)
        (found by: org.biopax.validator.rules.XrefDbCRRule)
      • object: INHIBITION
        property: db requires exactly 1 value(s)
        (found by: org.biopax.validator.rules.XrefDbCRRule)
      • object: PHYSICAL_STIMULATION
        property: db requires exactly 1 value(s)
        (found by: org.biopax.validator.rules.XrefDbCRRule)
      • object: STATE_TRANSITION
        property: db requires exactly 1 value(s)
        (found by: org.biopax.validator.rules.XrefDbCRRule)
      • object: TRANSCRIPTION
        property: db requires exactly 1 value(s)
        (found by: org.biopax.validator.rules.XrefDbCRRule)
      • object: TRANSLATION
        property: db requires exactly 1 value(s)
        (found by: org.biopax.validator.rules.XrefDbCRRule)
      • object: TRANSPORT
        property: db requires exactly 1 value(s)
        (found by: org.biopax.validator.rules.XrefDbCRRule)

    • ERROR: no.unification.xref , category: RECOMMENDATION,  cases: 3,  not fixed: 3
      EntityReference does not have a UnificationXref. Recommended best practice is to associate each entity reference with a unificiation xref to at least one of the common entity databases such as UniProt
      • object: HGNC_6973
        (found by: org.biopax.validator.rules.EntityReferenceXrefRule)
      • object: HGNC_8975
        (found by: org.biopax.validator.rules.EntityReferenceXrefRule)
      • object: HGNC_9588
        (found by: org.biopax.validator.rules.EntityReferenceXrefRule)

    • ERROR: no.xrefs , category: RECOMMENDATION,  cases: 2,  not fixed: 2
      EntityReference does not have any xrefs
      • object: HGNC_12023
        (found by: org.biopax.validator.rules.EntityReferenceXrefRule)
      • object: HGNC_6974
        (found by: org.biopax.validator.rules.EntityReferenceXrefRule)

    • WARNING: cardinality.violated , category: SPECIFICATION,  cases: 35,  not fixed: 35
      Cardinality violation
      • object: _FKHR_s38_a66_rs1_
        property: featureLocation requires exactly 1 value(s)
        (found by: org.biopax.validator.rules.ModificationFeatureLocationCRRule)
      • object: _FKHR_s38_a66_rs2_
        property: featureLocation requires exactly 1 value(s)
        (found by: org.biopax.validator.rules.ModificationFeatureLocationCRRule)
      • object: _FKHR_s41_a61_rs1_
        property: featureLocation requires exactly 1 value(s)
        (found by: org.biopax.validator.rules.ModificationFeatureLocationCRRule)
      • object: _FKHR_s41_a61_rs2_
        property: featureLocation requires exactly 1 value(s)
        (found by: org.biopax.validator.rules.ModificationFeatureLocationCRRule)
      • object: _FKHR_s49_a76_rs1_
        property: featureLocation requires exactly 1 value(s)
        (found by: org.biopax.validator.rules.ModificationFeatureLocationCRRule)
      • object: _FKHR_s49_a76_rs2_
        property: featureLocation requires exactly 1 value(s)
        (found by: org.biopax.validator.rules.ModificationFeatureLocationCRRule)
      • object: _GSK_3_s39_a65_rs1_
        property: featureLocation requires exactly 1 value(s)
        (found by: org.biopax.validator.rules.ModificationFeatureLocationCRRule)
      • object: _GSK_3_s43_a62_rs1_
        property: featureLocation requires exactly 1 value(s)
        (found by: org.biopax.validator.rules.ModificationFeatureLocationCRRule)
      • object: _IRS_1_4_s22_a8_rs1_
        property: featureLocation requires exactly 1 value(s)
        (found by: org.biopax.validator.rules.ModificationFeatureLocationCRRule)
      • object: _IRS_1_4_s7_a7_rs1_
        property: featureLocation requires exactly 1 value(s)
        (found by: org.biopax.validator.rules.ModificationFeatureLocationCRRule)
      • object: _Mdm2_s53_a80_rs1_
        property: featureLocation requires exactly 1 value(s)
        (found by: org.biopax.validator.rules.ModificationFeatureLocationCRRule)
      • object: _Mdm2_s54_a81_rs1_
        property: featureLocation requires exactly 1 value(s)
        (found by: org.biopax.validator.rules.ModificationFeatureLocationCRRule)
      • object: _PKB_s35_a53_rs1_
        property: featureLocation requires exactly 1 value(s)
        (found by: org.biopax.validator.rules.ModificationFeatureLocationCRRule)
      • object: _PKB_s37_a57_rs1_
        property: featureLocation requires exactly 1 value(s)
        (found by: org.biopax.validator.rules.ModificationFeatureLocationCRRule)
      • object: _Tsc2_s12_sa6_rs1_
        property: featureLocation requires exactly 1 value(s)
        (found by: org.biopax.validator.rules.ModificationFeatureLocationCRRule)
      • object: _Tsc2_s13_sa7_rs1_
        property: featureLocation requires exactly 1 value(s)
        (found by: org.biopax.validator.rules.ModificationFeatureLocationCRRule)
      • object: _Tsc2_s62_a106_rs1_
        property: featureLocation requires exactly 1 value(s)
        (found by: org.biopax.validator.rules.ModificationFeatureLocationCRRule)
      • object: CELLDESIGNER_INTERACTION_VOCABULARY=DISSOCIATION
        property: xref requires exactly 1 value(s)
        (found by: org.biopax.validator.rules.ControlledVocabularyXrefCRRule)
      • object: CELLDESIGNER_INTERACTION_VOCABULARY=HETERODIMER_ASSOCIATION
        property: xref requires exactly 1 value(s)
        (found by: org.biopax.validator.rules.ControlledVocabularyXrefCRRule)
      • object: CELLDESIGNER_INTERACTION_VOCABULARY=STATE_TRANSITION
        property: xref requires exactly 1 value(s)
        (found by: org.biopax.validator.rules.ControlledVocabularyXrefCRRule)
      • object: CELLDESIGNER_INTERACTION_VOCABULARY=TRANSCRIPTION
        property: xref requires exactly 1 value(s)
        (found by: org.biopax.validator.rules.ControlledVocabularyXrefCRRule)
      • object: CELLDESIGNER_INTERACTION_VOCABULARY=TRANSLATION
        property: xref requires exactly 1 value(s)
        (found by: org.biopax.validator.rules.ControlledVocabularyXrefCRRule)
      • object: CELLDESIGNER_INTERACTION_VOCABULARY=TRANSPORT
        property: xref requires exactly 1 value(s)
        (found by: org.biopax.validator.rules.ControlledVocabularyXrefCRRule)
      • object: CELLDESIGNER_REACTION_TYPE=DISSOCIATION
        property: xref requires exactly 1 value(s)
        (found by: org.biopax.validator.rules.ControlledVocabularyXrefCRRule)
      • object: CELLDESIGNER_REACTION_TYPE=HETERODIMER_ASSOCIATION
        property: xref requires exactly 1 value(s)
        (found by: org.biopax.validator.rules.ControlledVocabularyXrefCRRule)
      • object: CELLDESIGNER_REACTION_TYPE=INHIBITION
        property: xref requires exactly 1 value(s)
        (found by: org.biopax.validator.rules.ControlledVocabularyXrefCRRule)
      • object: CELLDESIGNER_REACTION_TYPE=PHYSICAL_STIMULATION
        property: xref requires exactly 1 value(s)
        (found by: org.biopax.validator.rules.ControlledVocabularyXrefCRRule)
      • object: CELLDESIGNER_REACTION_TYPE=STATE_TRANSITION
        property: xref requires exactly 1 value(s)
        (found by: org.biopax.validator.rules.ControlledVocabularyXrefCRRule)
      • object: CELLDESIGNER_REACTION_TYPE=TRANSCRIPTION
        property: xref requires exactly 1 value(s)
        (found by: org.biopax.validator.rules.ControlledVocabularyXrefCRRule)
      • object: CELLDESIGNER_REACTION_TYPE=TRANSLATION
        property: xref requires exactly 1 value(s)
        (found by: org.biopax.validator.rules.ControlledVocabularyXrefCRRule)
      • object: CELLDESIGNER_REACTION_TYPE=TRANSPORT
        property: xref requires exactly 1 value(s)
        (found by: org.biopax.validator.rules.ControlledVocabularyXrefCRRule)
      • object: MODIFICATION_FEATURE_phosphorylated
        property: xref requires exactly 1 value(s)
        (found by: org.biopax.validator.rules.ControlledVocabularyXrefCRRule)
      • object: PANTHER_GROUPING_8
        property: xref requires exactly 1 value(s)
        (found by: org.biopax.validator.rules.ControlledVocabularyXrefCRRule)
      • object: SEQUENCE_REGION_VOCABULARY__lys
        property: xref requires exactly 1 value(s)
        (found by: org.biopax.validator.rules.ControlledVocabularyXrefCRRule)
      • object: SEQUENCE_REGION_VOCABULARY__ser,_thr
        property: xref requires exactly 1 value(s)
        (found by: org.biopax.validator.rules.ControlledVocabularyXrefCRRule)

    • WARNING: illegal.conversion , category: INFORMATION,  cases: 4,  not fixed: 4
      A bio-polymer (i.e., not a complex or small molecule) is either missing or "becomes" another type on the other side of the same Conversion interaction (except for Degradation and ComplexAssembly)
      • object: _p53_s50_a77_
        conversion: STATE_TRANSITION_LEFT__p53-RIGHT__p53-_re22
        (found by: org.biopax.validator.rules.SimplePhysicalEntityConversionRule)
      • object: _p53_s56_a84_
        conversion: STATE_TRANSITION_LEFT__p53-RIGHT__p53-_re22
        (found by: org.biopax.validator.rules.SimplePhysicalEntityConversionRule)
      • object: _PKB_s35_a53_
        conversion: STATE_TRANSITION_LEFT__AKT-_ATP-RIGHT__ADP-_AKT-_r22
        (found by: org.biopax.validator.rules.SimplePhysicalEntityConversionRule)
      • object: _PKB_s37_a57_
        conversion: STATE_TRANSITION_LEFT__AKT-_ATP-RIGHT__ADP-_AKT-_r22
        (found by: org.biopax.validator.rules.SimplePhysicalEntityConversionRule)

    • WARNING: illegal.cv.term , category: SPECIFICATION,  cases: 14,  not fixed: 14
      Term is not found in the recommended controlled vocabulary (- wrong name/spelling or the identifier/accession is used instead of the term)
      • object: CELLDESIGNER_INTERACTION_VOCABULARY=DISSOCIATION
        Illegal term(s): [DISSOCIATION]; [Valid 'MI' terms: ALL children of MI:0190]
        (found by: org.biopax.validator.rules.InteractionTypeCvRule)
      • object: CELLDESIGNER_INTERACTION_VOCABULARY=HETERODIMER_ASSOCIATION
        Illegal term(s): [HETERODIMER_ASSOCIATION]; [Valid 'MI' terms: ALL children of MI:0190]
        (found by: org.biopax.validator.rules.InteractionTypeCvRule)
      • object: CELLDESIGNER_INTERACTION_VOCABULARY=STATE_TRANSITION
        Illegal term(s): [STATE_TRANSITION]; [Valid 'MI' terms: ALL children of MI:0190]
        (found by: org.biopax.validator.rules.InteractionTypeCvRule)
      • object: CELLDESIGNER_INTERACTION_VOCABULARY=TRANSCRIPTION
        Illegal term(s): [TRANSCRIPTION]; [Valid 'MI' terms: ALL children of MI:0190]
        (found by: org.biopax.validator.rules.InteractionTypeCvRule)
      • object: CELLDESIGNER_INTERACTION_VOCABULARY=TRANSLATION
        Illegal term(s): [TRANSLATION]; [Valid 'MI' terms: ALL children of MI:0190]
        (found by: org.biopax.validator.rules.InteractionTypeCvRule)
      • object: CELLDESIGNER_INTERACTION_VOCABULARY=TRANSPORT
        Illegal term(s): [TRANSPORT]; [Valid 'MI' terms: ALL children of MI:0190]
        (found by: org.biopax.validator.rules.InteractionTypeCvRule)
      • object: CELLDESIGNER_REACTION_TYPE=DISSOCIATION
        Illegal term(s): [DISSOCIATION]; [Valid 'MI' terms: ALL children of MI:0353]
        (found by: org.biopax.validator.rules.RelationshipTypeCvRule)
      • object: CELLDESIGNER_REACTION_TYPE=HETERODIMER_ASSOCIATION
        Illegal term(s): [HETERODIMER_ASSOCIATION]; [Valid 'MI' terms: ALL children of MI:0353]
        (found by: org.biopax.validator.rules.RelationshipTypeCvRule)
      • object: CELLDESIGNER_REACTION_TYPE=INHIBITION
        Illegal term(s): [INHIBITION]; [Valid 'MI' terms: ALL children of MI:0353]
        (found by: org.biopax.validator.rules.RelationshipTypeCvRule)
      • object: CELLDESIGNER_REACTION_TYPE=PHYSICAL_STIMULATION
        Illegal term(s): [PHYSICAL_STIMULATION]; [Valid 'MI' terms: ALL children of MI:0353]
        (found by: org.biopax.validator.rules.RelationshipTypeCvRule)
      • object: CELLDESIGNER_REACTION_TYPE=STATE_TRANSITION
        Illegal term(s): [STATE_TRANSITION]; [Valid 'MI' terms: ALL children of MI:0353]
        (found by: org.biopax.validator.rules.RelationshipTypeCvRule)
      • object: CELLDESIGNER_REACTION_TYPE=TRANSCRIPTION
        Illegal term(s): [TRANSCRIPTION]; [Valid 'MI' terms: ALL children of MI:0353]
        (found by: org.biopax.validator.rules.RelationshipTypeCvRule)
      • object: CELLDESIGNER_REACTION_TYPE=TRANSLATION
        Illegal term(s): [TRANSLATION]; [Valid 'MI' terms: ALL children of MI:0353]
        (found by: org.biopax.validator.rules.RelationshipTypeCvRule)
      • object: CELLDESIGNER_REACTION_TYPE=TRANSPORT
        Illegal term(s): [TRANSPORT]; [Valid 'MI' terms: ALL children of MI:0353]
        (found by: org.biopax.validator.rules.RelationshipTypeCvRule)

    • WARNING: min.cardinality.violated , category: SPECIFICATION,  cases: 10,  not fixed: 10
      Minimal cardinality violation
      • object: _FKHR_PROTEIN
        property: organism requires at least 1 value(s).
        (found by: org.biopax.validator.rules.GenericProteinReferenceOrganismRule)
      • object: _GSK_minus_3_PROTEIN
        property: organism requires at least 1 value(s).
        (found by: org.biopax.validator.rules.GenericProteinReferenceOrganismRule)
      • object: _INSR_br_IGF_minus_R_br_IRR_PROTEIN
        property: organism requires at least 1 value(s).
        (found by: org.biopax.validator.rules.GenericProteinReferenceOrganismRule)
      • object: _Insulin_br_IGF_PROTEIN
        property: organism requires at least 1 value(s).
        (found by: org.biopax.validator.rules.GenericProteinReferenceOrganismRule)
      • object: _IRS_space_1_minus_4_PROTEIN
        property: organism requires at least 1 value(s).
        (found by: org.biopax.validator.rules.GenericProteinReferenceOrganismRule)
      • object: _Mdm2_PROTEIN
        property: organism requires at least 1 value(s).
        (found by: org.biopax.validator.rules.GenericProteinReferenceOrganismRule)
      • object: _PTEN_PROTEIN
        property: organism requires at least 1 value(s).
        (found by: org.biopax.validator.rules.GenericProteinReferenceOrganismRule)
      • object: MODIFICATION_FEATURE_phosphorylated
        property: term requires at least 1 value(s).
        (found by: org.biopax.validator.rules.ControlledVocabularyTermCRRule)
      • object: SEQUENCE_REGION_VOCABULARY__lys
        property: term requires at least 1 value(s).
        (found by: org.biopax.validator.rules.ControlledVocabularyTermCRRule)
      • object: SEQUENCE_REGION_VOCABULARY__ser,_thr
        property: term requires at least 1 value(s).
        (found by: org.biopax.validator.rules.ControlledVocabularyTermCRRule)

    • WARNING: multiple.location , category: INFORMATION,  cases: 2,  not fixed: 2
      Participants span multiple cellular locations. This may be an error e.g. if the cellular locations do not connect to each other. Check that this information makes sense
      • object: DISSOCIATION_LEFT__Complex__Tsc2_Tsc1_-RIGHT__Tsc1-_Tsc2-_re38
        participants: _Tsc2_s62_a106_, _Tsc1_s65_a107_
        (found by: org.biopax.validator.rules.InteractionParticipantsLocationRule)
      • object: HETERODIMER_ASSOCIATION_LEFT__Insulin_IGF-_INSR_IGF_R_IRR-RIGHT__Complex__Insulin_IGF_INSR_IGF_R_IRR_-_r1
        participants: _Insulin_IGF_s2_a2_, _INSR_IGF_R_IRR_s1_a1_
        (found by: org.biopax.validator.rules.InteractionParticipantsLocationRule)

    • WARNING: no.display.name , category: RECOMMENDATION,  cases: 23,  all fixed!
      No display name is specified. It is useful to have one for the visualization purposes
      • [FIXED!]  object: HGNC_12023
        (found by: org.biopax.validator.rules.DisplayNameRule)
      • [FIXED!]  object: HGNC_6973
        (found by: org.biopax.validator.rules.DisplayNameRule)
      • [FIXED!]  object: HGNC_6974
        (found by: org.biopax.validator.rules.DisplayNameRule)
      • [FIXED!]  object: HGNC_8975
        (found by: org.biopax.validator.rules.DisplayNameRule)
      • [FIXED!]  object: HGNC_9588
        (found by: org.biopax.validator.rules.DisplayNameRule)
      • [FIXED!]  object: http://identifiers.org/uniprot/O14654
        (found by: org.biopax.validator.rules.DisplayNameRule)
      • [FIXED!]  object: http://identifiers.org/uniprot/O15151
        (found by: org.biopax.validator.rules.DisplayNameRule)
      • [FIXED!]  object: http://identifiers.org/uniprot/O43524
        (found by: org.biopax.validator.rules.DisplayNameRule)
      • [FIXED!]  object: http://identifiers.org/uniprot/P01308
        (found by: org.biopax.validator.rules.DisplayNameRule)
      • [FIXED!]  object: http://identifiers.org/uniprot/P01344
        (found by: org.biopax.validator.rules.DisplayNameRule)
      • [FIXED!]  object: http://identifiers.org/uniprot/P05019
        (found by: org.biopax.validator.rules.DisplayNameRule)
      • [FIXED!]  object: http://identifiers.org/uniprot/P06213
        (found by: org.biopax.validator.rules.DisplayNameRule)
      • [FIXED!]  object: http://identifiers.org/uniprot/P08069
        (found by: org.biopax.validator.rules.DisplayNameRule)
      • [FIXED!]  object: http://identifiers.org/uniprot/P11717
        (found by: org.biopax.validator.rules.DisplayNameRule)
      • [FIXED!]  object: http://identifiers.org/uniprot/P14616
        (found by: org.biopax.validator.rules.DisplayNameRule)
      • [FIXED!]  object: http://identifiers.org/uniprot/P35568
        (found by: org.biopax.validator.rules.DisplayNameRule)
      • [FIXED!]  object: http://identifiers.org/uniprot/P49840
        (found by: org.biopax.validator.rules.DisplayNameRule)
      • [FIXED!]  object: http://identifiers.org/uniprot/P49841
        (found by: org.biopax.validator.rules.DisplayNameRule)
      • [FIXED!]  object: http://identifiers.org/uniprot/P56180
        (found by: org.biopax.validator.rules.DisplayNameRule)
      • [FIXED!]  object: http://identifiers.org/uniprot/P60484
        (found by: org.biopax.validator.rules.DisplayNameRule)
      • [FIXED!]  object: http://identifiers.org/uniprot/Q00987
        (found by: org.biopax.validator.rules.DisplayNameRule)
      • [FIXED!]  object: http://identifiers.org/uniprot/Q12778
        (found by: org.biopax.validator.rules.DisplayNameRule)
      • [FIXED!]  object: http://identifiers.org/uniprot/Q9Y4H2
        (found by: org.biopax.validator.rules.DisplayNameRule)

    • WARNING: no.xref.cv.terms , category: RECOMMENDATION,  cases: 1,  all fixed!
      Controlled vocabulary(-ies) without unification xrefs for some of the (valid) terms
      • [FIXED!]  object: PANTHER_GROUPING_8
        terms: {By Homology=[OntologyTermImpl{acc='MI:2163', name='by homology'}]}; MI:2163 added!; info: [Valid 'MI' terms: ALL children of MI:0353]
        (found by: org.biopax.validator.rules.RelationshipTypeCvRule)

    • WARNING: no.xrefs , category: RECOMMENDATION,  cases: 10,  not fixed: 10
      EntityReference does not have any xrefs
      • object: _FKHR_PROTEIN
        (found by: org.biopax.validator.rules.GenericEntityReferenceXrefRule)
      • object: _GSK_minus_3_PROTEIN
        (found by: org.biopax.validator.rules.GenericEntityReferenceXrefRule)
      • object: _INSR_br_IGF_minus_R_br_IRR_PROTEIN
        (found by: org.biopax.validator.rules.GenericEntityReferenceXrefRule)
      • object: _Insulin_br_IGF_PROTEIN
        (found by: org.biopax.validator.rules.GenericEntityReferenceXrefRule)
      • object: _IRS_space_1_minus_4_PROTEIN
        (found by: org.biopax.validator.rules.GenericEntityReferenceXrefRule)
      • object: _Mdm2_GENE
        (found by: org.biopax.validator.rules.GenericEntityReferenceXrefRule)
      • object: _Mdm2_PROTEIN
        (found by: org.biopax.validator.rules.GenericEntityReferenceXrefRule)
      • object: _p110_alpha__GENE
        (found by: org.biopax.validator.rules.GenericEntityReferenceXrefRule)
      • object: _PTEN_GENE
        (found by: org.biopax.validator.rules.GenericEntityReferenceXrefRule)
      • object: _PTEN_PROTEIN
        (found by: org.biopax.validator.rules.GenericEntityReferenceXrefRule)

    • WARNING: null.entity.reference , category: RECOMMENDATION,  cases: 9,  not fixed: 9
      A Protein, SmallMolecule, etc. (but not a complex) has neither 'entityReference' (highly recommended) nor 'memberPhysicalEntity' values set
      • object: _Mdm2_s74_a82_
        entityReference (range: RnaRegionReference) is null, and memberPhysicalEntity is empty
        (found by: org.biopax.validator.rules.RnaRegionEntityReferenceRule)
      • object: _p110alpha_s72_a86_
        entityReference (range: RnaRegionReference) is null, and memberPhysicalEntity is empty
        (found by: org.biopax.validator.rules.RnaRegionEntityReferenceRule)
      • object: _p53_s50_a77_
        entityReference (range: ProteinReference) is null, and memberPhysicalEntity is empty
        (found by: org.biopax.validator.rules.ProteinEntityReferenceRule)
      • object: _p53_s56_a84_
        entityReference (range: ProteinReference) is null, and memberPhysicalEntity is empty
        (found by: org.biopax.validator.rules.ProteinEntityReferenceRule)
      • object: _PI3_K_s29_a46_
        entityReference (range: ProteinReference) is null, and memberPhysicalEntity is empty
        (found by: org.biopax.validator.rules.ProteinEntityReferenceRule)
      • object: _PI3_K_s6_sa3_
        entityReference (range: ProteinReference) is null, and memberPhysicalEntity is empty
        (found by: org.biopax.validator.rules.ProteinEntityReferenceRule)
      • object: _PKB_s35_a53_
        entityReference (range: ProteinReference) is null, and memberPhysicalEntity is empty
        (found by: org.biopax.validator.rules.ProteinEntityReferenceRule)
      • object: _PKB_s37_a57_
        entityReference (range: ProteinReference) is null, and memberPhysicalEntity is empty
        (found by: org.biopax.validator.rules.ProteinEntityReferenceRule)
      • object: _PTEN_s73_a78_
        entityReference (range: RnaRegionReference) is null, and memberPhysicalEntity is empty
        (found by: org.biopax.validator.rules.RnaRegionEntityReferenceRule)

    • WARNING: too.long.display.name , category: RECOMMENDATION,  cases: 42,  not fixed: 42
      'displayName' exceeds the recommended maximum. These names should be kept short so they can easily be displayed, e.g., in a pathway diagram
      • object: _Cell_growth_low_ROS_high_HSP_s63_a92_
        Cell growth low ROS high HSP, length=28 exceeds 25
        (found by: org.biopax.validator.rules.DisplayNameRule)
      • object: _Complex__Insulin_IGF_INSR_IGF_R_IRR__s5_a5_
        Complex (Insulin IGF/INSR IGF-R IRR), length=36 exceeds 25
        (found by: org.biopax.validator.rules.DisplayNameRule)
      • object: _Glucose_depreivation_response_s70_a108_
        Glucose depreivation response, length=29 exceeds 25
        (found by: org.biopax.validator.rules.DisplayNameRule)
      • object: DISSOCIATION_LEFT__Complex__Tsc2_Tsc1_-RIGHT__Tsc1-_Tsc2-_re38
        DISSOCIATION_LEFT__Complex__Tsc2_Tsc1_-RIGHT__Tsc1-_Tsc2-_re38, length=62 exceeds 25
        (found by: org.biopax.validator.rules.DisplayNameRule)
      • object: HETERODIMER_ASSOCIATION_LEFT__Insulin_IGF-_INSR_IGF_R_IRR-RIGHT__Complex__Insulin_IGF_INSR_IGF_R_IRR_-_r1
        HETERODIMER_ASSOCIATION_LEFT__Insulin_IGF-_INSR_IGF_R_IRR-RIGHT__Complex__Insulin_IGF_INSR_IGF_R_IRR_-_r1, length=105 exceeds 25
        (found by: org.biopax.validator.rules.DisplayNameRule)
      • object: HETERODIMER_ASSOCIATION_LEFT__P110alpha-_PI3_K-RIGHT__Complex__PI3_K_P110alpha_-_re25
        HETERODIMER_ASSOCIATION_LEFT__P110alpha-_PI3_K-RIGHT__Complex__PI3_K_P110alpha_-_re25, length=85 exceeds 25
        (found by: org.biopax.validator.rules.DisplayNameRule)
      • object: HGNC_12023
        Putative tyrosine-protein phosphatase TPTE(auto-created form other names!), length=42 exceeds 25
        (found by: org.biopax.validator.rules.DisplayNameRule)
      • object: HGNC_6973
        E3 ubiquitin-protein ligase Mdm2(auto-created form other names!), length=32 exceeds 25
        (found by: org.biopax.validator.rules.DisplayNameRule)
      • object: HGNC_8975
        Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(auto-created form other names!), length=78 exceeds 25
        (found by: org.biopax.validator.rules.DisplayNameRule)
      • object: HGNC_9588
        Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN(auto-created form other names!), length=100 exceeds 25
        (found by: org.biopax.validator.rules.DisplayNameRule)
      • object: http://identifiers.org/panther.pathway/P00033
        Insulin/IGF pathway-protein kinase B signaling cascade, length=54 exceeds 25
        (found by: org.biopax.validator.rules.DisplayNameRule)
      • object: http://identifiers.org/uniprot/O14654
        Insulin receptor substrate 4(auto-created form other names!), length=28 exceeds 25
        (found by: org.biopax.validator.rules.DisplayNameRule)
      • object: http://identifiers.org/uniprot/P01344
        Insulin-like growth factor II(auto-created form other names!), length=29 exceeds 25
        (found by: org.biopax.validator.rules.DisplayNameRule)
      • object: http://identifiers.org/uniprot/P05019
        Insulin-like growth factor I(auto-created form other names!), length=28 exceeds 25
        (found by: org.biopax.validator.rules.DisplayNameRule)
      • object: http://identifiers.org/uniprot/P08069
        Insulin-like growth factor 1 receptor(auto-created form other names!), length=37 exceeds 25
        (found by: org.biopax.validator.rules.DisplayNameRule)
      • object: http://identifiers.org/uniprot/P11717
        Cation-independent mannose-6-phosphate receptor(auto-created form other names!), length=47 exceeds 25
        (found by: org.biopax.validator.rules.DisplayNameRule)
      • object: http://identifiers.org/uniprot/P14616
        Insulin receptor-related protein(auto-created form other names!), length=32 exceeds 25
        (found by: org.biopax.validator.rules.DisplayNameRule)
      • object: http://identifiers.org/uniprot/P35568
        Insulin receptor substrate 1(auto-created form other names!), length=28 exceeds 25
        (found by: org.biopax.validator.rules.DisplayNameRule)
      • object: http://identifiers.org/uniprot/P49840
        Glycogen synthase kinase-3 alpha(auto-created form other names!), length=32 exceeds 25
        (found by: org.biopax.validator.rules.DisplayNameRule)
      • object: http://identifiers.org/uniprot/P49841
        Glycogen synthase kinase-3 beta(auto-created form other names!), length=31 exceeds 25
        (found by: org.biopax.validator.rules.DisplayNameRule)
      • object: http://identifiers.org/uniprot/P56180
        Putative tyrosine-protein phosphatase TPTE(auto-created form other names!), length=42 exceeds 25
        (found by: org.biopax.validator.rules.DisplayNameRule)
      • object: http://identifiers.org/uniprot/P60484
        Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN(auto-created form other names!), length=100 exceeds 25
        (found by: org.biopax.validator.rules.DisplayNameRule)
      • object: http://identifiers.org/uniprot/Q00987
        E3 ubiquitin-protein ligase Mdm2(auto-created form other names!), length=32 exceeds 25
        (found by: org.biopax.validator.rules.DisplayNameRule)
      • object: http://identifiers.org/uniprot/Q9Y4H2
        Insulin receptor substrate 2(auto-created form other names!), length=28 exceeds 25
        (found by: org.biopax.validator.rules.DisplayNameRule)
      • object: re47
        STATE_TRANSITION_LEFT__p53-RIGHT__s77-_re47, length=43 exceeds 25
        (found by: org.biopax.validator.rules.DisplayNameRule)
      • object: STATE_TRANSITION_LEFT__AKT-_ATP-RIGHT__ADP-_AKT-_r22
        STATE_TRANSITION_LEFT__AKT-_ATP-RIGHT__ADP-_AKT-_r22, length=52 exceeds 25
        (found by: org.biopax.validator.rules.DisplayNameRule)
      • object: STATE_TRANSITION_LEFT__ATP-_FKHR-RIGHT__ADP-_FKHR-_r26
        STATE_TRANSITION_LEFT__ATP-_FKHR-RIGHT__ADP-_FKHR-_r26, length=54 exceeds 25
        (found by: org.biopax.validator.rules.DisplayNameRule)
      • object: STATE_TRANSITION_LEFT__Complex__Tsc1_Tsc2_-RIGHT__Complex__Tsc2_Tsc1_-_re37
        STATE_TRANSITION_LEFT__Complex__Tsc1_Tsc2_-RIGHT__Complex__Tsc2_Tsc1_-_re37, length=75 exceeds 25
        (found by: org.biopax.validator.rules.DisplayNameRule)
      • object: STATE_TRANSITION_LEFT__GSK_3-_ATP-RIGHT__GSK_3-_ADP-_r24
        STATE_TRANSITION_LEFT__GSK_3-_ATP-RIGHT__GSK_3-_ADP-_r24, length=56 exceeds 25
        (found by: org.biopax.validator.rules.DisplayNameRule)
      • object: STATE_TRANSITION_LEFT__IRS_1_4-_ATP-RIGHT__IRS_1_4-_ADP-_r2
        STATE_TRANSITION_LEFT__IRS_1_4-_ATP-RIGHT__IRS_1_4-_ADP-_r2, length=59 exceeds 25
        (found by: org.biopax.validator.rules.DisplayNameRule)
      • object: STATE_TRANSITION_LEFT__Mdm2-RIGHT__Mdm2-_re19
        STATE_TRANSITION_LEFT__Mdm2-RIGHT__Mdm2-_re19, length=45 exceeds 25
        (found by: org.biopax.validator.rules.DisplayNameRule)
      • object: STATE_TRANSITION_LEFT__p53-RIGHT__p53-_re22
        STATE_TRANSITION_LEFT__p53-RIGHT__p53-_re22, length=43 exceeds 25
        (found by: org.biopax.validator.rules.DisplayNameRule)
      • object: STATE_TRANSITION_LEFT__PDK1_2-RIGHT__PDK1_2-_r21
        STATE_TRANSITION_LEFT__PDK1_2-RIGHT__PDK1_2-_r21, length=48 exceeds 25
        (found by: org.biopax.validator.rules.DisplayNameRule)
      • object: STATE_TRANSITION_LEFT__PiP2-RIGHT__PiP3-_r19
        STATE_TRANSITION_LEFT__PiP2-RIGHT__PiP3-_r19, length=44 exceeds 25
        (found by: org.biopax.validator.rules.DisplayNameRule)
      • object: STATE_TRANSITION_LEFT__PiP3-RIGHT__PiP2-_r20
        STATE_TRANSITION_LEFT__PiP3-RIGHT__PiP2-_r20, length=44 exceeds 25
        (found by: org.biopax.validator.rules.DisplayNameRule)
      • object: TRANSCRIPTION_LEFT__Mdm2-RIGHT__Mdm2-_re44
        TRANSCRIPTION_LEFT__Mdm2-RIGHT__Mdm2-_re44, length=42 exceeds 25
        (found by: org.biopax.validator.rules.DisplayNameRule)
      • object: TRANSCRIPTION_LEFT__p110alpha-RIGHT__p110alpha-_re42
        TRANSCRIPTION_LEFT__p110alpha-RIGHT__p110alpha-_re42, length=52 exceeds 25
        (found by: org.biopax.validator.rules.DisplayNameRule)
      • object: TRANSCRIPTION_LEFT__PTEN-RIGHT__PTEN-_re43
        TRANSCRIPTION_LEFT__PTEN-RIGHT__PTEN-_re43, length=42 exceeds 25
        (found by: org.biopax.validator.rules.DisplayNameRule)
      • object: TRANSLATION_LEFT__Mdm2-RIGHT__Mdm2-_re39
        TRANSLATION_LEFT__Mdm2-RIGHT__Mdm2-_re39, length=40 exceeds 25
        (found by: org.biopax.validator.rules.DisplayNameRule)
      • object: TRANSLATION_LEFT__p110alpha-RIGHT__P110alpha-_re40
        TRANSLATION_LEFT__p110alpha-RIGHT__P110alpha-_re40, length=50 exceeds 25
        (found by: org.biopax.validator.rules.DisplayNameRule)
      • object: TRANSLATION_LEFT__PTEN-RIGHT__PTEN-_re41
        TRANSLATION_LEFT__PTEN-RIGHT__PTEN-_re41, length=40 exceeds 25
        (found by: org.biopax.validator.rules.DisplayNameRule)
      • object: TRANSPORT_LEFT__FKHR-RIGHT__FKHR-_r30
        TRANSPORT_LEFT__FKHR-RIGHT__FKHR-_r30, length=37 exceeds 25
        (found by: org.biopax.validator.rules.DisplayNameRule)