PROLINE BIOSYNTHESIS I%HUMANCYC%PROSYN-PWY proline biosynthesis I 209027 66194 56454 69051 THIO-MOLYBDENUM COFACTOR BIOSYNTHESIS%HUMANCYC%PWY-5963 thio-molybdenum cofactor biosynthesis 68591 GLYCEROL DEGRADATION I%HUMANCYC%PWY-4261 glycerol degradation I 14933 235533 14626 MOLYBDENUM COFACTOR BIOSYNTHESIS%HUMANCYC%PWY-6823 molybdenum cofactor biosynthesis 18041 69372 17434 268566 OXIDATIVE ETHANOL DEGRADATION III%HUMANCYC%PWY66-161 oxidative ethanol degradation III 11671 13106 68738 60525 11669 TETRAPYRROLE BIOSYNTHESIS II%HUMANCYC%PWY-5189 tetrapyrrole biosynthesis II 15288 11655 22276 11656 17025 ASPARAGINE DEGRADATION I%HUMANCYC%ASPARAGINE-DEG1-PWY asparagine degradation I 66514 104816 TETRAHYDROBIOPTERIN BIOSYNTHESIS I%HUMANCYC%PWY-5663 tetrahydrobiopterin biosynthesis I 19286 14528 20751 UREA CYCLE%HUMANCYC%PWY-4984 urea cycle 11898 18416 11846 109900 11847 227231 4-HYDROXYPHENYLPYRUVATE BIOSYNTHESIS%HUMANCYC%PWY-5886 4-hydroxyphenylpyruvate biosynthesis 234724 KETOGENESIS%HUMANCYC%REACT_1464.NULL ketogenesis 231086 110446 71911 113868 15356 15360 CDP-DIACYLGLYCEROL BIOSYNTHESIS I%HUMANCYC%PWY-5667 CDP-diacylglycerol biosynthesis I 215456 77582 68262 28169 67469 67216 225010 55979 52123 231510 67512 14571 99010 110911 14732 74596 14792 102247 SELENOCYSTEINE BIOSYNTHESIS II (ARCHAEA AND EUKARYOTES)%HUMANCYC%PWY-6281 selenocysteine biosynthesis II (archaea and eukaryotes) 211006 20768 214580 20226 71984 109079 CATECHOLAMINE BIOSYNTHESIS%HUMANCYC%PWY66-301 catecholamine biosynthesis 18948 13195 RAPOPORT-LUEBERING GLYCOLYTIC SHUNT%HUMANCYC%PWY-6405 Rapoport-Luebering glycolytic shunt 17330 12183 18648 56012 L-CARNITINE BIOSYNTHESIS%HUMANCYC%PWY-6100 L-carnitine biosynthesis 56752 192289 170442 ASPARAGINE BIOSYNTHESIS I%HUMANCYC%ASPARAGINE-BIOSYNTHESIS asparagine biosynthesis I 27053 UDP-D-XYLOSE AND UDP-D-GLUCURONATE BIOSYNTHESIS%HUMANCYC%PWY-4821 UDP-D-xylose and UDP-D-glucuronate biosynthesis 67883 22235 4-HYDROXY-2-NONENAL DETOXIFICATION%HUMANCYC%PWY-7112 4-hydroxy-2-nonenal detoxification 14859 100042314 GUANINE AND GUANOSINE SALVAGE I%HUMANCYC%PWY-6620 guanine and guanosine salvage I 18950 15452 GDP-MANNOSE BIOSYNTHESIS%HUMANCYC%PWY-5659 GDP-mannose biosynthesis 69080 14751 29858 54128 331026 110119 THREONINE DEGRADATION II%HUMANCYC%THREONINE-DEG2-PWY threonine degradation II 26912 SUPERPATHWAY OF D-MYO< I>-INOSITOL (1,4,5)-TRISPHOSPHATE METABOLISM%HUMANCYC%PWY-6358 superpathway of D-myo< i>-inositol (1,4,5)-trisphosphate metabolism 19062 228550 242291 233011 320404 20975 55980 114663 320634 104015 17330 16331 212111 16332 16330 69718 16329 19211 101490 S-ADENOSYL-L-METHIONINE BIOSYNTHESIS%HUMANCYC%SAM-PWY S-adenosyl-L-methionine biosynthesis 11720 232087 108645 D-MYO< I>-INOSITOL (1,4,5)-TRISPHOSPHATE DEGRADATION%HUMANCYC%PWY-6363 D-myo< i>-inositol (1,4,5)-trisphosphate degradation 55980 114663 320634 104015 212111 16332 16330 19062 16329 101490 242291 20975 GUANOSINE NUCLEOTIDES DEGRADATION III%HUMANCYC%PWY-6608 guanosine nucleotides degradation III 76952 22436 18950 14544 MAP KINASE CASCADE%HUMANCYC%REACT_634.NULL MAP kinase cascade 54401 ASPARTATE BIOSYNTHESIS%HUMANCYC%ASPARTATESYN-PWY aspartate biosynthesis 76615 14718 14719 XANTHINE AND XANTHOSINE SALVAGE%HUMANCYC%SALVPURINE2-PWY xanthine and xanthosine salvage 18950 GLYCINE BIOSYNTHESIS I%HUMANCYC%GLYSYN-PWY glycine biosynthesis I 20425 108037 GALACTOSE DEGRADATION I (LELOIR PATHWAY)%HUMANCYC%PWY-6317 galactose degradation I (Leloir pathway) 74246 14430 14635 319625 BMP SIGNALLING PATHWAY%HUMANCYC%REACT_12034.NULL BMP Signalling Pathway 216080 17128 20481 12156 66105 GDP-GLUCOSE BIOSYNTHESIS%HUMANCYC%PWY-5661 GDP-glucose biosynthesis 226041 216019 66681 72157 103988 DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE BIOSYNTHESIS%HUMANCYC%MANNOSYL-CHITO-DOLICHOL-BIOSYNTHESIS dolichyl-diphosphooligosaccharide biosynthesis 320438 13478 68563 381903 66248 208624 13480 208211 SUPEROXIDE RADICALS DEGRADATION%HUMANCYC%DETOX1-PWY superoxide radicals degradation 22178 12359 667310 20657 20656 GLUTATHIONE BIOSYNTHESIS%HUMANCYC%GLUTATHIONESYN-PWY glutathione biosynthesis 14630 14854 14629 MYO< I>-INOSITOL BIOSYNTHESIS%HUMANCYC%PWY-2301 myo< i>-inositol biosynthesis 55980 114663 71780 242291 PYRIDOXAL 5'-PHOSPHATE SALVAGE PATHWAY%HUMANCYC%PLPSAL-PWY pyridoxal 5'-phosphate salvage pathway 216134 103711 GLYCINE BIOSYNTHESIS III%HUMANCYC%GLYSYN-ALA-PWY glycine biosynthesis III 11611 268782 ARGININE DEGRADATION VI (ARGINASE 2 PATHWAY)%HUMANCYC%ARG-PRO-PWY arginine degradation VI (arginase 2 pathway) 209027 66194 18242 69051 11846 11847 CITRULLINE-NITRIC OXIDE CYCLE%HUMANCYC%PWY-4983 citrulline-nitric oxide cycle 18126 18125 18127 11898 109900 PHOSPHATIDYLGLYCEROL BIOSYNTHESIS II (NON-PLASTIDIC)%HUMANCYC%PWY4FS-8 phosphatidylglycerol biosynthesis II (non-plastidic) 215456 74451 77582 68262 28169 67469 67216 225010 55979 52123 231510 67512 14571 99010 110911 14732 74596 14792 102247 L-DOPA DEGRADATION%HUMANCYC%PWY-6334 L-dopa degradation 12846 SALVAGE PATHWAYS OF PYRIMIDINE RIBONUCLEOTIDES%HUMANCYC%PWY0-163 salvage pathways of pyrimidine ribonucleotides 79059 433968 171567 22271 18102 54369 76654 22245 11628 80914 72269 331487 75533 56520 68556 SULFATE ACTIVATION FOR SULFONATION%HUMANCYC%PWY-5340 sulfate activation for sulfonation 23971 23972 TYROSINE DEGRADATION I%HUMANCYC%TYRFUMCAT-PWY tyrosine degradation I 234724 15233 15445 14085 14874 SPERMINE BIOSYNTHESIS%HUMANCYC%ARGSPECAT-PWY spermine biosynthesis 671878 PURINE NUCLEOTIDES DE NOVO< I> BIOSYNTHESIS II%HUMANCYC%PWY-841 purine nucleotides de novo< i> biosynthesis II 11565 11564 67054 231327 23917 229363 237823 11566 108147 14450 100042069 GLUTAMINE DEGRADATION I%HUMANCYC%GLUTAMINDEG-PWY glutamine degradation I 216456 14660 27053 SEROTONIN DEGRADATION%HUMANCYC%PWY-6313 serotonin degradation 11671 11669 20887 17161 100727 109731 EUMELANIN BIOSYNTHESIS%HUMANCYC%PWY-6498 eumelanin biosynthesis 22178 13190 22063 22173 COLANIC ACID BUILDING BLOCKS BIOSYNTHESIS%HUMANCYC%COLANSYN-PWY colanic acid building blocks biosynthesis 69080 14751 29858 54128 331026 110119 74246 14430 14635 216558 218138 22122 22235 GLUCONEOGENESIS I%HUMANCYC%GLUCONEO-PWY gluconeogenesis I 18655 14751 107029 100043349 14120 18663 17436 17449 230163 14447 14121 13806 13808 11674 109264 17448 18534 13807 12183 13003 18648 56012 D-MANNOSE DEGRADATION%HUMANCYC%MANNCAT-PWY D-mannose degradation 110119 FLAVIN BIOSYNTHESIS IV (MAMMALIAN)%HUMANCYC%11070 flavin biosynthesis IV (mammalian) 319945 54391 S< I>-METHYL-5-THIO-&ALPHA;-D-RIBOSE 1-PHOSPHATE DEGRADATION%HUMANCYC%PWY-6755 S< i>-methyl-5-thio-α-D-ribose 1-phosphate degradation 67870 56369 104923 67873 FATTY ACID &BETA;-OXIDATION III (UNSATURATED, ODD NUMBER)%HUMANCYC%PWY-5137 fatty acid β-oxidation III (unsaturated, odd number) 13177 23986 74147 GLYCINE DEGRADATION (CREATINE BIOSYNTHESIS)%HUMANCYC%GLYCGREAT-PWY glycine degradation (creatine biosynthesis) 14431 67092 TRIACYLGLYCEROL BIOSYNTHESIS%HUMANCYC%TRIGLSYN-PWY triacylglycerol biosynthesis 215456 77582 68262 28169 67469 67216 225010 55979 19012 13350 52123 67916 229791 50784 231510 67512 216152 68393 99010 67800 381925 235044 14732 14792 102247 GLUTAMATE DEPENDENT ACID RESISTANCE%HUMANCYC%PWY0-1305 glutamate dependent acid resistance 14415 14417 TREHALOSE DEGRADATION II (TREHALASE)%HUMANCYC%PWY0-1182 trehalose degradation II (trehalase) 216019 319625 103988 58866 &ALPHA;-TOCOPHEROL DEGRADATION%HUMANCYC%PWY-6377 α-tocopherol degradation 106648 SPERMINE AND SPERMIDINE DEGRADATION I%HUMANCYC%PWY-6117 spermine and spermidine degradation I 212503 11754 228608 20229 69215 NAD SALVAGE PATHWAY III%HUMANCYC%PWY3O-4106 NAD salvage pathway III 225994 69564 226518 66454 74080 PYRUVATE FERMENTATION TO LACTATE%HUMANCYC%PWY-5481 pyruvate fermentation to lactate 16828 106557 16833 16832 NAD BIOSYNTHESIS FROM 2-AMINO-3-CARBOXYMUCONATE SEMIALDEHYDE%HUMANCYC%PWY-5653 NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde 67375 226518 66454 74080 78914 FATTY ACID BIOSYNTHESIS INITIATION II%HUMANCYC%PWY-5966 fatty acid biosynthesis initiation II 71147 14104 PUTRESCINE DEGRADATION III%HUMANCYC%PWY-0 putrescine degradation III 11671 20229 72535 69215 67689 11670 11669 17161 109731 DIPHTHAMIDE BIOSYNTHESIS%HUMANCYC%PWY-6482 diphthamide biosynthesis 69740 CHOLESTEROL BIOSYNTHESIS III (VIA DESMOSTEROL)%HUMANCYC%PWY66-4 cholesterol biosynthesis III (via desmosterol) 98386 13595 13121 20775 16987 73166 18194 14137 235293 66234 74754 13360 15490 TAURINE BIOSYNTHESIS%HUMANCYC%PWY-5331 taurine biosynthesis 246277 12583 4-AMINOBUTYRATE DEGRADATION I%HUMANCYC%PWY-6535 4-aminobutyrate degradation I 268860 214579 TRNA SPLICING%HUMANCYC%PWY-6689 tRNA splicing 107328 76265 66078 66637 381802 TETRAHYDROBIOPTERIN BIOSYNTHESIS II%HUMANCYC%PWY-5664 tetrahydrobiopterin biosynthesis II 19286 14528 20751 NAD SALVAGE PATHWAY II%HUMANCYC%NAD-BIOSYNTHESIS-II NAD salvage pathway II 66659 235534 209558 18605 225994 69564 226518 66454 74080 67993 23959 68106 PUTRESCINE BIOSYNTHESIS III%HUMANCYC%PWY-46 putrescine biosynthesis III 18263 242669 ADENOSINE NUCLEOTIDES DEGRADATION II%HUMANCYC%SALVADEHYPOX-PWY adenosine nucleotides degradation II 76952 22436 11486 18950 230718 107569 23959 4-HYDROXYBENZOATE BIOSYNTHESIS%HUMANCYC%PWY-5754-1 4-hydroxybenzoate biosynthesis 234724 LYSINE DEGRADATION II%HUMANCYC%LYSINE-DEG1-PWY lysine degradation II 30956 110695 109232 ZYMOSTEROL BIOSYNTHESIS%HUMANCYC%PWY-6074 zymosterol biosynthesis 13121 98386 73166 18194 66234 15490 TRYPTOPHAN DEGRADATION III (EUKARYOTIC)%HUMANCYC%TRYPTOPHAN-DEGRADATION-1 tryptophan degradation III (eukaryotic) 56720 70789 231086 270076 110446 266645 110460 113868 98256 107766 71562 ADENINE AND ADENOSINE SALVAGE I%HUMANCYC%P121-PWY adenine and adenosine salvage I 11821 COENZYME A BIOSYNTHESIS%HUMANCYC%COA-PWY coenzyme A biosynthesis 66812 106564 71743 INOSITOL PYROPHOSPHATES BIOSYNTHESIS%HUMANCYC%PWY-6369 inositol pyrophosphates biosynthesis 69718 327655 227399 27399 75678 271424 76500 D-MYO< I>-INOSITOL (1,3,4)-TRISPHOSPHATE BIOSYNTHESIS%HUMANCYC%PWY-6364 D-myo< i>-inositol (1,3,4)-trisphosphate biosynthesis 19062 228550 233011 320404 20975 320634 104015 17330 16331 212111 16332 16330 69718 19211 HISTIDINE DEGRADATION III%HUMANCYC%PWY-5030 histidine degradation III 15109 243537 17768 108156 71761 665563 14317 SUPERPATHWAY OF GERANYLGERANYLDIPHOSPHATE BIOSYNTHESIS I (VIA MEVALONATE)%HUMANCYC%PWY-5910 superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate) 319554 15357 231086 110446 100040592 110196 113868 14593 110460 17855 15360 68603 192156 L-CYSTEINE DEGRADATION II%HUMANCYC%LCYSDEG-PWY L-cysteine degradation II 107869 PHOSPHATIDYLETHANOLAMINE BIOSYNTHESIS III%HUMANCYC%PWY-6273 phosphatidylethanolamine biosynthesis III 27388 THIOSULFATE DISPROPORTIONATION III (RHODANESE)%HUMANCYC%PWY-5350 thiosulfate disproportionation III (rhodanese) 22117 UDP-N< I>-ACETYL-D-GALACTOSAMINE BIOSYNTHESIS I%HUMANCYC%PWY-5512 UDP-N< i>-acetyl-D-galactosamine biosynthesis I 74246 L-CYSTEINE DEGRADATION III%HUMANCYC%PWY-5329 L-cysteine degradation III 246221 PHOSPHOLIPASES%HUMANCYC%LIPASYN-PWY phospholipases 66350 18782 234779 18803 18795 104759 18805 114875 78390 26970 53357 269615 18778 271844 26565 18802 67452 269437 18806 237625 18798 329502 74055 18797 18796 665270 18799 18807 18784 18783 18256 26971 232889 72469 225845 GLUTATHIONE-MEDIATED DETOXIFICATION I%HUMANCYC%PWY-4061 glutathione-mediated detoxification I 667301 71522 14598 211666 14871 16790 56615 66447 14874 207182 76263 14862 14866 14865 68214 68312 14863 14859 100042314 SUPERPATHWAY OF CHOLESTEROL BIOSYNTHESIS%HUMANCYC%PWY66-5 superpathway of cholesterol biosynthesis 319554 15357 98386 13595 231086 13121 20775 110446 16987 73166 100040592 18194 110196 14137 235293 14593 113868 66234 17855 74754 15360 68603 13360 192156 15490 110460 CHONDROITIN SULFATE DEGRADATION (METAZOA)%HUMANCYC%PWY-6573 chondroitin sulfate degradation (metazoa) 15586 77042 74468 11881 50917 15211 ACETYL-COA BIOSYNTHESIS III (FROM CITRATE)%HUMANCYC%PWY-5172 acetyl-CoA biosynthesis III (from citrate) 104112 TRYPTOPHAN DEGRADATION TO 2-AMINO-3-CARBOXYMUCONATE SEMIALDEHYDE%HUMANCYC%PWY-5651 tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde 56720 70789 98256 107766 71562 DOLICHOL AND DOLICHYL PHOSPHATE BIOSYNTHESIS%HUMANCYC%PWY-6129 dolichol and dolichyl phosphate biosynthesis 67422 57357 227697 ACYL-COA HYDROLYSIS%HUMANCYC%PWY-5148 acyl-CoA hydrolysis 70025 170789 56360 STEARATE BIOSYNTHESIS I (ANIMALS)%HUMANCYC%PWY-5972 stearate biosynthesis I (animals) 171281 50790 94180 433256 14081 70025 171210 170439 74205 54325 328845 26458 171282 SUPERPATHWAY OF INOSITOL PHOSPHATE COMPOUNDS%HUMANCYC%PWY-6371 superpathway of inositol phosphate compounds 97287 52858 18719 18720 217837 320207 327655 227399 27399 75678 271424 76500 18802 269437 18798 74055 18797 18796 18799 72469 234779 18803 18795 114875 269615 320634 104015 16331 212111 16332 16330 69718 19211 108083 225326 18717 219024 19062 18711 228550 104709 227733 224020 233011 18709 320404 84095 75669 20975 18706 74769 117150 103199 17330 18708 30955 18707 107650 72519 18704 240752 18705 18710 83493 74302 67073 DOPAMINE DEGRADATION%HUMANCYC%PWY6666-2 dopamine degradation 11671 20887 12846 17161 109731 METHYLTHIOPROPIONATE BIOSYNTHESIS%HUMANCYC%PWY-5389 methylthiopropionate biosynthesis 104923 URACIL DEGRADATION II (REDUCTIVE)%HUMANCYC%PWY-3982 uracil degradation II (reductive) 12933 12934 64705 103149 22240 26757 65254 99586 1D-MYO< I>-INOSITOL HEXAKISPHOSPHATE BIOSYNTHESIS V (FROM INS(1,3,4)P3)%HUMANCYC%PWY-6554 1D-myo< i>-inositol hexakisphosphate biosynthesis V (from Ins(1,3,4)P3) 217837 69718 75678 S< I>-METHYL-5'-THIOADENOSINE DEGRADATION II%HUMANCYC%PWY-6756 S< i>-methyl-5'-thioadenosine degradation II 66902 PHOSPHATIDYLCHOLINE BIOSYNTHESIS I%HUMANCYC%PWY3O-450 phosphatidylcholine biosynthesis I 99712 236899 12660 212862 12651 13026 TRIACYLGLYCEROL DEGRADATION%HUMANCYC%LIPAS-PWY triacylglycerol degradation 18947 23945 66082 16890 76192 12613 66853 116939 15450 16891 69060 67717 GLYCEROL-3-PHOSPHATE SHUTTLE%HUMANCYC%PWY-6118 glycerol-3-phosphate shuttle 14555 14571 GLUTARYL-COA DEGRADATION%HUMANCYC%PWY-5177 glutaryl-CoA degradation 231086 270076 110446 110460 113868 TRANS, TRANS< I>-FARNESYL DIPHOSPHATE BIOSYNTHESIS%HUMANCYC%PWY-5123 trans, trans< i>-farnesyl diphosphate biosynthesis 319554 110196 14593 GLUTAMATE REMOVAL FROM FOLATES%HUMANCYC%PWY-2161B glutamate removal from folates 667301 GERANYLGERANYLDIPHOSPHATE BIOSYNTHESIS%HUMANCYC%PWY-5120 geranylgeranyldiphosphate biosynthesis 14593 ACYL CARRIER PROTEIN METABOLISM%HUMANCYC%PWY-6012 acyl carrier protein metabolism 67618 1D-MYO< I>-INOSITOL HEXAKISPHOSPHATE BIOSYNTHESIS II (MAMMALIAN)%HUMANCYC%PWY-6362 1D-myo< i>-inositol hexakisphosphate biosynthesis II (mammalian) 217837 19062 228550 75678 233011 320404 20975 320634 104015 16331 212111 16332 16330 69718 CHOLESTEROL BIOSYNTHESIS I%HUMANCYC%PWY66-341 cholesterol biosynthesis I 98386 13595 13121 20775 16987 73166 18194 14137 235293 66234 74754 13360 15490 ALANINE BIOSYNTHESIS II%HUMANCYC%ALANINE-SYN2-PWY alanine biosynthesis II 108682 76282 FATTY ACID &ALPHA;-OXIDATION II%HUMANCYC%PWY66-387 fatty acid α-oxidation II 56794 50790 216739 94180 16922 433256 14081 74205 328845 26458 GLUTAMINE BIOSYNTHESIS I%HUMANCYC%GLNSYN-PWY glutamine biosynthesis I 14645 PHENYLETHYLAMINE DEGRADATION I%HUMANCYC%2PHENDEG-PWY phenylethylamine degradation I 11754 11671 11669 237940 MEVALONATE PATHWAY I%HUMANCYC%PWY-922 mevalonate pathway I 231086 319554 110446 15357 100040592 110460 113868 17855 15360 68603 192156 SPHINGOMYELIN METABOLISM%HUMANCYC%PWY3DJ-11281 sphingomyelin metabolism 208449 77626 20597 20598 58994 67630 74442 238011 CYSTEINE BIOSYNTHESIS HOMOCYSTEINE DEGRADATION%HUMANCYC%HOMOCYSDEGR-PWY cysteine biosynthesis homocysteine degradation 107869 12411 GDP-L-FUCOSE BIOSYNTHESIS I (FROM GDP-D-MANNOSE)%HUMANCYC%PWY-66 GDP-L-fucose biosynthesis I (from GDP-D-mannose) 218138 22122 SUPERPATHWAY OF SERINE AND GLYCINE BIOSYNTHESIS I%HUMANCYC%SER-GLYSYN-PWY superpathway of serine and glycine biosynthesis I 236539 100678 107272 20425 108037 5-AMINOIMIDAZOLE RIBONUCLEOTIDE BIOSYNTHESIS I%HUMANCYC%PWY-6121 5-aminoimidazole ribonucleotide biosynthesis I 231327 237823 14450 GDP-L-FUCOSE BIOSYNTHESIS II (FROM L-FUCOSE)%HUMANCYC%PWY-6 GDP-L-fucose biosynthesis II (from L-fucose) 234730 75540 N< I>-ACETYLGLUCOSAMINE DEGRADATION I%HUMANCYC%GLUAMCAT-PWY N< i>-acetylglucosamine degradation I 26384 67980 245847 D-MYO< I>-INOSITOL (1,4,5,6)-TETRAKISPHOSPHATE BIOSYNTHESIS%HUMANCYC%PWY-6366 D-myo< i>-inositol (1,4,5,6)-tetrakisphosphate biosynthesis 17330 217837 69718 UDP-N< I>-ACETYL-D-GALACTOSAMINE BIOSYNTHESIS II%HUMANCYC%PWY-5514 UDP-N< i>-acetyl-D-galactosamine biosynthesis II 14751 74246 109785 216019 107652 26384 54342 103988 67980 2-AMINO-3-CARBOXYMUCONATE SEMIALDEHYDE DEGRADATION TO GLUTARYL-COA%HUMANCYC%PWY-5652 2-amino-3-carboxymuconate semialdehyde degradation to glutaryl-CoA 266645 L-SERINE DEGRADATION%HUMANCYC%SERDEG-PWY L-serine degradation 231691 257635 ACETATE CONVERSION TO ACETYL-COA%HUMANCYC%PWY0-1313 acetate conversion to acetyl-CoA 68738 60525 THYROID HORMONE BIOSYNTHESIS%HUMANCYC%PWY-6241 thyroid hormone biosynthesis 22018 13033 ANDROGEN BIOSYNTHESIS%HUMANCYC%PWY66-378 androgen biosynthesis 105349 13074 94224 15487 78925 15497 15492 FOLATE POLYGLUTAMYLATION%HUMANCYC%PWY-2161 folate polyglutamylation 270685 14287 20425 108156 108037 CHOLINE BIOSYNTHESIS III%HUMANCYC%PWY-3561 choline biosynthesis III 99712 236899 104759 18805 212862 18806 18807 13026 INOSINE-5'-PHOSPHATE BIOSYNTHESIS II%HUMANCYC%PWY-6124 inosine-5'-phosphate biosynthesis II 11564 67054 108147 DERMATAN SULFATE BIOSYNTHESIS (LATE STAGES)%HUMANCYC%PWY-6568 dermatan sulfate biosynthesis (late stages) 212898 72136 77590 338362 URATE BIOSYNTHESIS INOSINE 5'-PHOSPHATE DEGRADATION%HUMANCYC%PWY-5695 urate biosynthesis inosine 5'-phosphate degradation 76952 22436 23917 18950 100042069 23959 68106 URIDINE-5'-PHOSPHATE BIOSYNTHESIS%HUMANCYC%PWY-5686 uridine-5'-phosphate biosynthesis 69719 22247 METHYLGLYOXAL DEGRADATION III%HUMANCYC%PWY-5453 methylglyoxal degradation III 13106 67861 11677 PURINE NUCLEOTIDES DEGRADATION II (AEROBIC)%HUMANCYC%PWY-6353 purine nucleotides degradation II (aerobic) 76952 22436 11486 23917 18950 230718 107569 100042069 23959 68106 14544 FATTY ACID ACTIVATION%HUMANCYC%PWY-5143 fatty acid activation 50790 216739 94180 433256 14081 74205 328845 26458 CERAMIDE DEGRADATION%HUMANCYC%PWY-6483 ceramide degradation 54447 SALVAGE PATHWAYS OF PYRIMIDINE DEOXYRIBONUCLEOTIDES%HUMANCYC%PWY0-181 salvage pathways of pyrimidine deoxyribonucleotides 11628 72269 72962 57813 21877 3-PHOSPHOINOSITIDE BIOSYNTHESIS%HUMANCYC%PWY-6352 3-phosphoinositide biosynthesis 52858 18719 18720 320207 108083 225326 18717 18711 104709 227733 224020 18709 84095 75669 18706 74769 103199 18708 30955 18707 107650 18704 240752 18705 18710 83493 67073 SPERMIDINE BIOSYNTHESIS I%HUMANCYC%BSUBPOLYAMSYN-PWY spermidine biosynthesis I 20810 ADENINE AND ADENOSINE SALVAGE III%HUMANCYC%PWY-6609 adenine and adenosine salvage III 11486 18950 15452 PROTEIN CITRULLINATION%HUMANCYC%PWY-4921 protein citrullination 242726 18599 18601 18602 18600 NAD BIOSYNTHESIS II (FROM TRYPTOPHAN)%HUMANCYC%NADSYN-PWY NAD biosynthesis II (from tryptophan) 56720 67375 70789 226518 66454 74080 98256 107766 78914 71562 PENTOSE PHOSPHATE PATHWAY%HUMANCYC%PENTOSE-P-PWY pentose phosphate pathway 14381 19895 21351 66646 74419 110208 83553 66171 21881 100198 D-MYO< I>-INOSITOL (1,4,5)-TRISPHOSPHATE BIOSYNTHESIS%HUMANCYC%PWY-6351 D-myo< i>-inositol (1,4,5)-trisphosphate biosynthesis 52858 234779 18802 18803 18719 18795 108083 18720 269437 18717 114875 269615 227733 224020 84095 18798 117150 74055 18797 18796 107650 18799 72469 67073 PROLINE BIOSYNTHESIS II (FROM ARGININE)%HUMANCYC%PWY-4981 proline biosynthesis II (from arginine) 209027 66194 18416 18242 69051 GLUTAMATE DEGRADATION II%HUMANCYC%GLUTDEG-PWY glutamate degradation II 76615 14718 14719 PENTOSE PHOSPHATE PATHWAY (OXIDATIVE BRANCH)%HUMANCYC%OXIDATIVEPENT-PWY pentose phosphate pathway (oxidative branch) 14381 110208 66171 100198 KETOLYSIS%HUMANCYC%REACT_59.NULL ketolysis 67041 231086 110446 71911 113868 69772 SPHINGOSINE AND SPHINGOSINE-1-PHOSPHATE METABOLISM%HUMANCYC%PWY3DJ-11470 sphingosine and sphingosine-1-phosphate metabolism 67103 230379 56632 171168 20698 81535 433323 54447 11886 HEME BIOSYNTHESIS II%HUMANCYC%PWY-5920 heme biosynthesis II 15288 11655 22276 11656 22275 19044 14151 12892 17025 HEME BIOSYNTHESIS FROM UROPORPHYRINOGEN-III I%HUMANCYC%HEME-BIOSYNTHESIS-II heme biosynthesis from uroporphyrinogen-III I 22275 19044 14151 12892 TYROSINE BIOSYNTHESIS IV%HUMANCYC%PWY-6134 tyrosine biosynthesis IV 18478 FATTY ACID &BETA;-OXIDATION I%HUMANCYC%FAO-PWY fatty acid β-oxidation I 93747 216739 50790 52538 94180 15108 433256 14081 97212 15107 231086 13177 23986 74205 113868 74147 328845 26458 CMP-N< I>-ACETYLNEURAMINATE BIOSYNTHESIS I (EUKARYOTES)%HUMANCYC%PWY-6138 CMP-N< i>-acetylneuraminate biosynthesis I (eukaryotes) 12764 50798 67311 94181 ARGININE BIOSYNTHESIS IV%HUMANCYC%ARGININE-SYN4-PWY arginine biosynthesis IV 11898 18416 18242 14661 109900 NORADRENALINE AND ADRENALINE DEGRADATION%HUMANCYC%PWY-6342 noradrenaline and adrenaline degradation 18948 11671 11669 12846 17161 791260 26876 109731 CARDIOLIPIN BIOSYNTHESIS II%HUMANCYC%PWY-5269 cardiolipin biosynthesis II 74451 66586 SERINE BIOSYNTHESIS%HUMANCYC%SERSYN-PWY serine biosynthesis 236539 100678 107272 SEROTONIN AND MELATONIN BIOSYNTHESIS%HUMANCYC%PWY-6030 serotonin and melatonin biosynthesis 13195 21990 216343 11298 ETHANOL DEGRADATION II%HUMANCYC%PWY66-21 ethanol degradation II 11671 68738 60525 11669 D-GLUCURONATE DEGRADATION I%HUMANCYC%PWY-5525 D-glucuronate degradation I 67880 68631 L-CYSTEINE DEGRADATION I%HUMANCYC%CYSTEINE-DEG-PWY L-cysteine degradation I 14718 12583 METHYLGLYOXAL DEGRADATION I%HUMANCYC%PWY-5386 methylglyoxal degradation I 14651 52815 109801 N< I>-ACETYLGLUCOSAMINE DEGRADATION II%HUMANCYC%PWY-6517 N< i>-acetylglucosamine degradation II 56174 26384 67980 245847 METHYLMALONYL PATHWAY%HUMANCYC%PROPIONMET-PWY methylmalonyl pathway 73724 66904 17850 110821 GLUTATHIONE REDOX REACTIONS I%HUMANCYC%PWY-4081 glutathione redox reactions I 14776 67305 14775 69590 14782 75512 14778 14780 625249 (S)-RETICULINE BIOSYNTHESIS II%HUMANCYC%PWY-6133 (S)-reticuline biosynthesis II 22173 CITRULLINE DEGRADATION%HUMANCYC%CITRULLINE-DEG-PWY citrulline degradation 18416 LACTOSE DEGRADATION III%HUMANCYC%BGALACT-PWY lactose degradation III 12091 GLUTAMATE DEGRADATION X%HUMANCYC%PWY-5766 glutamate degradation X 14661 L-DOPACHROME BIOSYNTHESIS%HUMANCYC%PWY-6481 L-dopachrome biosynthesis 22173 PRPP BIOSYNTHESIS I%HUMANCYC%PWY0-662 PRPP biosynthesis I 75456 19139 110639 SORBITOL DEGRADATION I%HUMANCYC%PWY-4101 sorbitol degradation I 20322 1,25-DIHYDROXYVITAMIN D3< SUB> BIOSYNTHESIS%HUMANCYC%PWY-6076 1,25-dihydroxyvitamin D3< sub> biosynthesis 18984 244209 13115 CERAMIDE BIOSYNTHESIS%HUMANCYC%PWY3DJ-12 ceramide biosynthesis 70750 20773 268656 70059 228677 L-GLUTAMINE BIOSYNTHESIS II (TRNA-DEPENDENT)%HUMANCYC%PWY-5921 L-glutamine biosynthesis II (tRNA-dependent) 229487 76563 ANANDAMIDE DEGRADATION%HUMANCYC%PWY6666-1 anandamide degradation 14073 PYRIMIDINE RIBONUCLEOTIDES INTERCONVERSION%HUMANCYC%PWY-5687 pyrimidine ribonucleotides interconversion 79059 66588 433968 22169 171567 18102 54369 51797 76025 55936 75533 56520 UDP-N< I>-ACETYL-D-GLUCOSAMINE BIOSYNTHESIS II%HUMANCYC%UDPNACETYLGALSYN-PWY UDP-N< i>-acetyl-D-glucosamine biosynthesis II 14584 14583 109785 107652 54342 HISTAMINE BIOSYNTHESIS%HUMANCYC%PWY-6173 histamine biosynthesis 15186 TRYPTOPHAN DEGRADATION X (MAMMALIAN, VIA TRYPTAMINE)%HUMANCYC%PWY-6307 tryptophan degradation X (mammalian, via tryptamine) 11671 13195 58810 17161 109731 DERMATAN SULFATE DEGRADATION (METAZOA)%HUMANCYC%PWY-6576 dermatan sulfate degradation (metazoa) 15586 74468 15932 15211 ALL-TRANS< I>-DECAPRENYL DIPHOSPHATE BIOSYNTHESIS%HUMANCYC%PWY-5806 all-trans< i>-decaprenyl diphosphate biosynthesis 56075 71365 THYMINE DEGRADATION%HUMANCYC%PWY-6430 thymine degradation 12933 12934 64705 103149 22240 26757 65254 99586 ALANINE BIOSYNTHESIS III%HUMANCYC%PWY0-1021 alanine biosynthesis III 18041 LANOSTEROL BIOSYNTHESIS%HUMANCYC%PWY-6132 lanosterol biosynthesis 16987 PYRIMIDINE RIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%HUMANCYC%PWY0-162 pyrimidine ribonucleotides de novo< i> biosynthesis 22247 66588 79059 22169 433968 171567 18102 51797 54369 69719 76025 55936 75533 56520 GLUCOSE AND GLUCOSE-1-PHOSPHATE DEGRADATION%HUMANCYC%GLUCOSE1PMETAB-PWY glucose and glucose-1-phosphate degradation 226041 216019 66681 72157 103988 OLEATE BIOSYNTHESIS II (ANIMALS)%HUMANCYC%PWY-5996 oleate biosynthesis II (animals) 171281 20249 328035 171210 56473 76267 171282 PHOSPHATIDYLETHANOLAMINE BIOSYNTHESIS II%HUMANCYC%PWY4FS-6 phosphatidylethanolamine biosynthesis II 99712 75320 68671 12651 28042 PHENYLALANINE DEGRADATION I (AEROBIC)%HUMANCYC%PHENYLALANINE-DEG1-PWY phenylalanine degradation I (aerobic) 13180 110391 72562 18478 CALCIUM TRANSPORT I%HUMANCYC%PWY-6166 calcium transport I 235574 11938 53313 11937 69047 PURINE RIBONUCLEOSIDES DEGRADATION TO RIBOSE-1-PHOSPHATE%HUMANCYC%PWY0-1296 purine ribonucleosides degradation to ribose-1-phosphate 11486 18950 4-HYDROXYPROLINE DEGRADATION I%HUMANCYC%HYDROXYPRODEG-PWY 4-hydroxyproline degradation I 212647 ASPARTATE DEGRADATION II%HUMANCYC%MALATE-ASPARTATE-SHUTTLE-PWY aspartate degradation II 76615 14718 14719 17449 17448 GLUTAMATE BIOSYNTHESIS II%HUMANCYC%GLUTAMATE-SYN2-PWY glutamate biosynthesis II 14661 CHOLESTEROL BIOSYNTHESIS II (VIA 24,25-DIHYDROLANOSTEROL)%HUMANCYC%PWY66-3 cholesterol biosynthesis II (via 24,25-dihydrolanosterol) 98386 13595 13121 20775 16987 73166 18194 14137 235293 66234 74754 13360 15490 GLUTAMATE DEGRADATION III (VIA 4-AMINOBUTYRATE)%HUMANCYC%GLUDEG-I-PWY glutamate degradation III (via 4-aminobutyrate) 14415 14417 268860 214579 GLYCOGEN DEGRADATION III%HUMANCYC%PWY-5767 glycogen degradation III 19309 110095 77559 14387 226041 232714 110078 66681 72157 ETHANOL DEGRADATION IV%HUMANCYC%PWY66-162 ethanol degradation IV 22178 12359 11671 68738 60525 11669 TETRAHYDROFOLATE SALVAGE FROM 5,10-METHENYLTETRAHYDROFOLATE%HUMANCYC%PWY-6613 tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate 17768 108156 665563 14450 EPOXYSQUALENE BIOSYNTHESIS%HUMANCYC%PWY-5670 epoxysqualene biosynthesis 20775 14137 CREATINE-PHOSPHATE BIOSYNTHESIS%HUMANCYC%PWY-6158 creatine-phosphate biosynthesis 76722 12716 12715 12709 NAD PHOSPHORYLATION AND DEPHOSPHORYLATION%HUMANCYC%NADPHOS-DEPHOS-PWY NAD phosphorylation and dephosphorylation 66659 235534 18115 192185 ADENINE AND ADENOSINE SALVAGE VI%HUMANCYC%PWY-6619 adenine and adenosine salvage VI 11534 D-MYO< I>-INOSITOL-5-PHOSPHATE METABOLISM%HUMANCYC%PWY-6367 D-myo< i>-inositol-5-phosphate metabolism 97287 234779 18802 18803 18795 269437 114875 219024 269615 18798 117150 74055 18797 18796 18799 72519 72469 74302 PENTOSE PHOSPHATE PATHWAY (NON-OXIDATIVE BRANCH)%HUMANCYC%NONOXIPENT-PWY pentose phosphate pathway (non-oxidative branch) 19895 21351 66646 74419 83553 21881 SULFITE OXIDATION IV%HUMANCYC%PWY-5326 sulfite oxidation IV 211389 NAD BIOSYNTHESIS III%HUMANCYC%NAD-BIOSYNTHESIS-III NAD biosynthesis III 59027 226518 66454 74080 METHYLGLYOXAL DEGRADATION VI%HUMANCYC%MGLDLCTANA-PWY methylglyoxal degradation VI 52815 &GAMMA;-GLUTAMYL CYCLE%HUMANCYC%PWY-4041 γ-glutamyl cycle 66054 75475 74388 68252 71522 14598 14630 14854 16790 14629 207182 LEUKOTRIENE BIOSYNTHESIS%HUMANCYC%15354 leukotriene biosynthesis 13479 319446 16993 11689 17001 NADH REPAIR%HUMANCYC%PWY-6938 NADH repair 100043349 246703 FORMALDEHYDE OXIDATION II (GLUTATHIONE-DEPENDENT)%HUMANCYC%PWY-1801 formaldehyde oxidation II (glutathione-dependent) 11532 13885 SUCROSE DEGRADATION V (MAMMALIAN)%HUMANCYC%PWY66-373 sucrose degradation V (mammalian) 16548 21991 69983 230163 319625 11674 2-OXOBUTANOATE DEGRADATION I%HUMANCYC%PWY-5130 2-oxobutanoate degradation I 73724 66904 17850 110821 13382 12039 13171 12040 3-PHOSPHOINOSITIDE DEGRADATION%HUMANCYC%PWY-6368 3-phosphoinositide degradation 97287 19062 219024 20975 66865 320634 104015 234515 16331 66461 269180 16332 234129 16330 72519 64436 19211 101490 83493 74302 DTMP DE NOVO< I> BIOSYNTHESIS%HUMANCYC%PWY66-385 dTMP de novo< i> biosynthesis 20425 108037 13361 22171 ARGININE DEGRADATION I (ARGINASE PATHWAY)%HUMANCYC%ARGASEDEG-PWY arginine degradation I (arginase pathway) 18242 11846 212647 11847 MITOCHONDRIAL L-CARNITINE SHUTTLE PATHWAY%HUMANCYC%PWY-6111 mitochondrial L-carnitine shuttle pathway 12896 78070 12894 &BETA;-ALANINE DEGRADATION I%HUMANCYC%BETA-ALA-DEGRADATION-I-PWY β-alanine degradation I 104776 268860 ALANINE DEGRADATION III%HUMANCYC%ALANINE-DEG3-PWY alanine degradation III 108682 76282 GLYCOGEN DEGRADATION II%HUMANCYC%PWY-5941 glycogen degradation II 19309 110095 77559 226041 110078 66681 72157 THIAMIN SALVAGE III%HUMANCYC%PWY-6898 thiamin salvage III 29807 D-MYO< I>-INOSITOL (3,4,5,6)-TETRAKISPHOSPHATE BIOSYNTHESIS%HUMANCYC%PWY-6365 D-myo< i>-inositol (3,4,5,6)-tetrakisphosphate biosynthesis 217837 69718 HISTAMINE DEGRADATION%HUMANCYC%PWY-6181 histamine degradation 76507 140483 237940 FATTY ACID &ALPHA;-OXIDATION III%HUMANCYC%PWY66-388 fatty acid α-oxidation III 56794 11671 GLYCOLYSIS I%HUMANCYC%GLYCOLYSIS glycolysis I 18655 14751 100043349 14120 18663 230163 18770 18746 14447 18642 14121 18641 13806 56421 13808 11674 21991 13807 12183 13003 18648 56012 OXIDIZED GTP AND DGTP DETOXIFICATION%HUMANCYC%PWY-6502 oxidized GTP and dGTP detoxification 17766 TRNA CHARGING%HUMANCYC%TRNA-CHARGING-PWY tRNA charging 110960 212679 105148 27267 244141 107271 224805 23874 70223 20226 71984 109093 102436 230577 22321 272396 107045 234734 22375 15115 66590 67417 226414 70791 71807 85305 70560 353172 381314 226539 71941 104458 70120 97541 107508 216443 69955 ALPHA6BETA4INTEGRIN%IOB%ALPHA6BETA4INTEGRIN Alpha6Beta4Integrin 13844 22627 20416 16772 19882 11651 20166 22352 22062 16418 14083 74769 13649 19247 109620 16777 20779 18753 18706 13684 14360 17295 14784 18750 226519 16776 19353 16367 384783 22631 59079 16779 18208 12821 12476 22612 13685 100039786 18709 16774 229933 18707 12015 16782 11835 18479 18710 17126 16403 16773 23844 55948 17127 22629 16785 54401 18708 18810 11350 192897 12367 30955 56717 213435 13866 16780 11848 TRAIL%IOB%TRAIL TRAIL 18035 19766 11651 20779 12370 19090 26409 11798 26417 12912 100039026 14082 12402 16151 12366 21933 15270 12070 12028 11545 65111 670717 50883 12042 11783 22035 11920 12369 22333 12018 18383 17210 12387 13030 27056 22030 26926 71609 26413 66593 26416 12362 26419 26420 12633 16476 12122 19697 18033 105787 12367 LEPTIN%IOB%LEPTIN Leptin 11651 14083 13649 19247 18753 15507 18754 110157 606496 13712 14784 16367 384783 26417 26397 26399 26413 26416 18033 18762 26396 21823 17164 18709 16419 20528 11909 16410 12632 16846 16847 192157 54611 17979 20112 20399 20846 20848 18708 20851 667739 19211 26395 16452 56637 14827 16453 20683 20218 IFN-ALPHA%IOB%IFN-ALPHA IFN-alpha 26397 18035 22324 18783 26398 26399 15976 54721 11651 18761 56458 20850 226652 15975 22637 20847 20849 12929 18753 26416 75705 20852 16367 384783 13685 12402 12928 20846 20848 73086 13867 20851 667739 16451 56717 NGF%IOB%NGF NGF 83945 18759 16179 109880 26396 327826 20416 26417 18803 12912 18211 14388 12015 20111 19247 20399 26413 13712 26395 20683 EGFR1%IOB%EGFR1 EGFR1 19766 13844 20416 11651 22352 14083 74769 13649 19247 109620 20779 18753 18706 14360 17295 14784 18750 19353 384783 22631 26417 12912 12402 59079 12821 13685 18709 18707 12015 18479 18710 17126 17127 54401 18708 18810 11350 192897 30955 56717 13866 11848 234779 16818 327826 17096 19229 18803 19261 108079 17973 20971 22325 12927 12631 12550 17869 100040260 21815 18760 227753 110157 606496 13712 23939 433759 72993 15259 12389 229615 12606 19303 110651 26934 12702 218397 12390 12534 11804 210126 27371 114479 232341 18596 18643 236576 20970 20404 19765 18806 16706 14251 208650 13448 15170 12703 26401 56324 23938 13860 16691 74256 19734 21873 26397 22324 54721 56458 20850 20847 12929 26413 26416 26419 26420 16476 19697 18033 105787 18762 26396 20112 20399 12928 20846 20848 73086 13867 20851 16451 19211 26395 16452 56637 20683 20218 17999 69710 20844 14609 21787 13043 11352 13511 26407 18752 216810 19248 12566 74155 67938 212139 19268 20195 76179 66713 24066 57257 17931 66952 16478 218518 78388 140721 19262 11746 12388 19707 22323 20437 15461 19267 109333 71889 20408 13835 20910 11836 16412 110308 11843 208618 18127 12322 110310 17709 231002 18738 66395 67760 67451 13132 66898 20663 11949 13710 12371 240753 18607 225870 171463 16400 21961 14252 11491 15239 13016 18751 53310 98432 11928 107435 73379 13642 26406 230126 16337 270190 13449 17920 18805 330662 19730 640703 20324 54366 286940 19134 22330 20969 13858 19108 18759 93742 20459 16835 20869 22687 14388 71770 13859 271457 74055 13845 23943 17775 14783 19252 208643 74326 215114 50915 238130 110078 54132 22059 18571 24045 11502 23980 16952 20909 229709 18938 11771 16668 72828 21346 26362 29806 230837 24064 15258 21881 16667 14281 229285 235406 15382 20239 14302 20403 19272 20662 21894 232906 209039 19727 51789 108100 16687 13714 69178 18648 72621 27387 72201 12558 26405 330914 13806 13838 226419 11740 30794 319939 194655 19285 545878 20617 60595 67859 109904 11308 227937 16480 239250 11820 26431 11674 13429 53378 101320 71514 16396 19246 20439 12757 13846 109880 223650 16828 64143 13205 56726 73178 14786 13628 224650 20111 23942 16332 13645 68481 56460 12568 140579 67300 67097 20194 80794 18746 56205 110355 14389 381126 217169 66166 12043 75454 58235 67184 19279 244418 53859 54473 235542 26400 12988 216963 216190 22051 13014 17974 19259 11431 20867 26936 399510 57783 15194 667279 29875 666899 12560 50766 109552 74117 104831 16590 319152 109135 107686 22042 71943 218441 105782 56455 54126 19084 240752 11855 20499 13196 69538 12608 109711 232910 58194 18003 226970 13549 54135 228136 13548 11657 17886 108705 19253 13209 59026 244895 74255 667618 226250 194590 24105 22038 13855 24063 13836 245688 12306 232431 208177 100043257 628438 394252 67941 333883 29815 321022 170643 98910 50932 50926 26377 13854 11461 22378 14924 NOTCH%IOB%NOTCH Notch 14199 14533 16818 19165 433586 20185 57750 17125 18133 19664 21402 21885 103806 14357 11487 18550 15208 15214 26965 16848 15182 433759 18223 56438 21423 13389 15205 17260 16656 17128 18129 19164 50754 26417 20602 18519 328572 18128 60406 18132 59287 17305 17172 22632 16450 140484 20466 100042305 13388 54485 16842 19763 11820 100039623 12805 56381 15213 18222 208117 18131 16396 270118 27401 16449 66935 55927 11491 26413 19697 18033 18709 17127 20848 18708 16452 56637 THROMBOPOIETIN%IOB%THROMBOPOIETIN Thrombopoietin 26413 20848 56484 26417 233871 20416 17480 20851 14388 26395 16452 M-CSF%IOB%M-CSF M-CSF 234779 19766 17096 20416 19229 18803 54353 17444 11651 22352 12927 14083 19247 20779 20662 18753 18754 110157 14784 19303 12370 218397 26417 14082 12402 15170 13429 54721 20850 16332 26413 14389 26396 13685 16410 360013 20846 58988 20848 16331 16416 209446 77799 18708 20851 12978 667739 16451 107829 224105 26395 17342 19255 210710 12977 23872 19052 19201 20218 TGF_BETA_RECEPTOR%IOB%TGF_BETA_RECEPTOR TGF_beta_Receptor 56484 20416 11651 18752 22062 12566 14083 21402 18753 26965 16478 14784 56438 17260 17128 26409 26417 18519 328572 12322 16842 13132 12387 59079 15239 18751 218441 93742 18709 20869 71770 11835 17126 17127 18708 22059 11848 19877 12005 21781 14272 17258 13426 12575 68999 217232 68015 12323 103236 52563 14282 12927 14281 17130 20901 16211 17869 14030 386655 17344 21815 12325 12006 13207 54601 67068 26411 20662 19085 13982 21808 110157 19645 56513 17977 13018 12447 216080 56469 227720 433759 12443 18854 13559 17131 26754 21809 20482 12389 18044 218210 12234 21417 12571 20692 19303 75465 83814 76630 11482 12442 12530 12534 15529 19042 272359 66313 23871 228026 22337 20742 15378 13163 11910 57258 12189 100041766 15481 56371 18744 21812 94112 19651 12393 13805 16396 24136 71978 20682 54709 26397 108058 56207 216869 75788 26399 211586 17222 18045 12505 56458 21813 66105 72183 93836 18046 230597 18102 69260 22601 19087 26413 13542 103573 26416 56317 16477 26419 269338 15405 66513 16476 97064 69150 75901 71728 67804 56440 19650 21814 21803 104394 52206 99152 20481 12914 11909 14225 67903 12567 12705 59008 14106 15228 69957 76793 12928 19052 20683 TIE1 TEK%IOB%TIE1 TEK TIE1 TEK 26396 12169 21687 14159 20416 26417 21846 11651 56458 14786 17973 20850 18479 14083 18127 26413 13449 26416 20851 110157 13712 26395 19303 TNFSF3%IOB%TNFSF3 TNFSF3 18035 16992 17000 22031 16994 19698 21938 18034 21937 22033 16476 19697 18033 22030 FLK2 FLT3%IOB%FLK2 FLT3 FLK2 FLT3 56484 17096 20416 26417 12912 14388 11909 11651 12015 12402 20850 14255 19247 100040260 20848 16331 26413 208650 20851 16476 14389 16452 12606 TNFSF8%IOB%TNFSF8 TNFSF8 18035 53859 11651 22031 19698 18034 22033 12675 16150 21949 26413 18036 19696 26416 12051 21941 22029 19697 18033 22030 FAS%IOB%FAS Fas 17999 19766 11651 22352 13649 18753 14360 17295 19353 11746 12370 19090 11798 109333 26417 100039026 14082 12366 12028 11545 12369 12371 22030 16337 333883 18810 12367 19877 16818 12169 17096 217232 22031 227753 15507 110157 15259 13665 19687 20230 21969 218397 21454 66587 12363 12380 16001 20740 26430 19192 66661 13347 26408 13163 16906 15170 22029 192656 26401 15235 22350 93687 22196 12537 21945 19106 58231 21843 18570 26885 63958 320795 101706 12048 12229 21841 14084 17193 67379 22390 14103 14102 26926 11857 50873 26413 56041 66593 26416 98488 12362 72322 27373 26419 17187 26420 12633 100042807 12368 12122 223255 19697 20807 75705 93692 13001 12043 56274 74153 26396 224105 26395 56637 EPO%IOB%EPO EPO 234779 18035 56484 17096 20416 18803 19882 11651 19247 54601 26411 110157 606496 384783 26417 12402 18127 109880 22324 56458 20850 20963 12929 26413 26419 26420 16476 14389 26396 18709 14388 12015 13857 94212 20846 20848 12125 16331 14460 73086 319183 14463 18708 20851 15163 13143 26395 16452 56717 56637 23921 20393 CCR1%IOB%CCR1 CCR1 26417 19229 20302 14083 22637 20846 20848 26413 20779 18753 26416 26419 16451 26420 12913 20303 20304 19697 14675 20306 12768 18033 19303 CCR9%IOB%CCR9 CCR9 19684 17698 16401 225825 26417 20300 12769 16421 11651 56458 12550 17123 26413 26416 26419 22350 56637 16453 BDNF%IOB%BDNF BDNF 327826 56484 20416 19229 18803 18211 19261 11651 108079 19698 107971 16491 26413 110157 26419 14360 26420 13712 23939 18212 14402 18053 17967 14812 16367 77480 14810 384783 14799 13685 26417 12912 12015 12326 140486 271849 21844 22084 100705 20964 20399 56717 56637 12387 23921 ID%IOB%ID ID 15901 20787 15903 17877 18504 15902 12566 17928 13713 17927 17878 21406 19185 15904 19645 18510 18507 21416 13712 13714 21423 15205 19650 11910 17127 19651 G-CSF%IOB%G-CSF G-CSF 22324 16818 12700 17096 21682 20416 16188 12985 54721 14319 11651 667310 20850 20963 20111 12566 19247 26413 26416 606496 27373 14784 14389 18759 18129 12702 26417 18128 12015 12402 18127 20846 20848 16331 19696 20851 16451 15162 107939 20977 16452 12576 56637 12986 18778 CXCR4%IOB%CXCR4 CXCR4 234779 18035 16818 56484 17096 19229 18803 11651 17973 20971 22325 12927 14083 12631 13649 100040260 19247 20779 18753 110157 14360 13712 19353 19303 110651 21785 12702 22329 218397 26417 12912 22376 12402 16822 12778 13983 15894 16885 12774 18712 12675 12767 16150 14674 59025 16428 18036 15481 208650 14677 13448 19264 15170 26385 12703 20315 12387 16414 23880 26397 22324 216869 54721 56458 20963 22637 20847 20849 12929 26413 19697 18033 18762 26396 16401 18709 12015 18479 20112 12928 20846 20848 16331 54401 20851 18708 667739 16451 26395 16452 56637 16453 11848 TNFSF1%IOB%TNFSF1 TNFSF1 29820 18035 230979 16992 11651 17000 22031 16994 16151 19698 21938 18034 21937 22033 16476 19697 18033 CCR7%IOB%CCR7 CCR7 56484 26398 19229 26417 11555 18803 100039973 12775 11651 100038965 56458 12631 26413 26416 26419 26420 16452 19697 56717 56637 26414 GDNF%IOB%GDNF GDNF 18035 19229 20416 18803 11651 12927 14083 100040260 20779 13449 26413 110157 14360 17295 114255 23939 16476 19713 14389 623279 12532 19303 76829 110651 26396 21823 26417 12534 12912 14388 12402 12928 208650 13448 18708 26395 WNT%IOB%WNT Wnt 11651 26407 18752 18504 17125 20779 18753 21416 18750 21423 19353 26409 26417 16842 13132 12387 20319 13543 330938 57265 72780 16973 208846 13016 109689 18751 22411 24117 20187 93897 18019 11789 18719 26563 239405 23988 192199 14368 14369 212398 13380 14296 226970 16202 13728 22612 22417 22421 22415 22412 320790 14366 84035 22420 84505 16971 13544 231103 20664 14370 22413 14365 22418 84095 19049 104318 54401 77578 26564 22408 20377 18099 18755 14371 19045 18747 16974 20379 20378 11848 12005 22419 21413 14367 22416 22422 14734 67943 11441 19016 16591 14362 13017 12550 216795 12006 18754 110157 606496 12443 12234 12571 12558 16480 26401 93687 216869 26398 18761 26413 13542 26419 27373 16476 58988 56637 19052 CD40%IOB%CD40 CD40 18035 234779 16818 17096 11651 22031 20963 14191 17869 11796 26413 26416 14360 26419 26420 16476 20852 26417 12675 16150 20846 20848 18708 26395 16453 22030 GM-CSF%IOB%GM-CSF GM-CSF 18035 20844 13844 56484 17096 21682 20416 14159 18803 11651 12927 18034 14694 19247 12982 59013 20525 56150 14376 110157 11757 606496 12465 13712 12981 23939 14784 57320 18750 12984 12934 384783 19303 22631 12370 26417 12912 12402 20740 18643 11545 12675 16150 12051 19264 15170 15162 56324 22350 26397 22324 18783 26399 20850 20963 12929 26413 26416 26419 26420 21814 22612 21803 26396 18709 14388 12015 20112 20846 20848 18708 20851 16451 26395 16452 56637 14827 16453 16590 23921 IFN-GAMMA%IOB%IFN-GAMMA IFN-gamma 234779 22324 18783 19229 11651 18761 20850 20847 13649 12929 12608 20779 26413 18753 26416 18754 110157 26419 16476 75705 20852 26417 12912 12402 16363 15900 15395 26403 15979 16362 20375 19094 12928 20846 20848 20851 667739 16451 16452 56637 18747 ANDROGENRECEPTOR%IOB%ANDROGENRECEPTOR AndrogenReceptor 11651 13649 20779 17128 12370 20602 18519 328572 11545 20466 12369 12387 11835 17127 18708 12367 19045 21413 14694 21815 17344 18760 227753 15507 13982 19645 17977 12447 56469 14884 57320 433759 12443 72993 15259 15469 12389 66671 229615 12606 22596 19303 214230 56710 81000 627557 21969 17978 16195 17246 12530 59004 22026 75352 101700 14815 12539 104156 12572 21804 53610 13163 14200 19183 12189 19384 19822 15481 30051 57314 56218 12531 56705 57782 12393 14375 18986 22196 268903 12537 107823 11739 192176 56406 23957 223870 75273 52915 18477 12017 22025 11863 56458 13195 81601 12317 15375 14797 18813 22668 108767 107951 56424 56736 68705 12362 11622 22027 18193 22294 100043349 16476 225115 217127 19697 12445 15519 232286 13144 170758 77627 107321 328365 22353 68098 14828 98053 17979 20848 19211 56637 20683 TNFALPHA%IOB%TNFALPHA TNFalpha 26406 13728 14388 22059 22031 19698 21938 18034 21937 22033 18854 12234 26405 12675 16150 18036 19696 12051 21941 22029 22196 13205 320795 20963 14084 53859 666899 319152 432502 18035 19766 22032 66997 22627 103583 11647 76589 193740 11651 26572 20588 170790 20017 70834 14083 211550 226525 21402 13649 27215 19247 20340 100043714 26410 231130 20779 16648 18753 18789 12455 26965 15516 69721 15182 228775 21926 56407 14229 227648 68652 17220 22631 16650 12370 18616 19173 26409 434174 50754 22682 446099 26417 66724 12912 77045 100039026 17218 14082 12091 15185 16151 64424 12366 21929 20019 107589 21934 12028 56480 18637 72416 19708 19179 71966 20587 50797 12369 68094 17463 19181 236733 56489 216150 20016 57751 53376 22030 22628 224619 67384 19182 12905 23881 23997 22123 71833 66413 67857 233406 19414 56456 80859 20018 16535 18037 70247 76784 56312 333654 76510 56399 73174 11797 109658 67891 16709 14113 18567 11652 100039786 22629 54401 12367 14694 15507 19645 433759 26754 12389 229615 56710 22026 12539 100041766 15481 13448 26401 23938 192176 26399 20850 66105 107951 71609 26413 26416 26419 26420 66513 12633 16476 12122 19697 15519 18033 18762 17164 14828 12914 26403 20586 27207 20846 18201 73086 230233 544963 65099 100039592 21353 56532 22034 26395 17846 57376 211651 14886 21762 245841 HEDGEHOG%IOB%HEDGEHOG Hedgehog 216869 22627 11651 17125 110355 13548 226861 14634 319757 59024 20423 19206 20481 15529 12914 19014 69792 16147 100041953 14633 13363 14632 264064 24069 19207 20466 117606 269209 15245 70208 75050 18747 12387 57810 14451 19335 21907 KITRECEPTOR%IOB%KITRECEPTOR KitReceptor 21682 17096 20416 14159 18803 11651 14191 19247 20779 20662 66713 56150 18706 110157 606496 14360 13712 14784 18750 12984 15461 218397 26417 328572 22376 12402 21933 67296 17311 16923 114715 16197 208650 54607 13448 114716 15170 14936 12703 15162 19273 14158 22324 18751 12229 14786 20850 20111 18019 12929 26413 67300 26416 58194 26419 16476 14389 19697 22612 13685 26396 18709 11909 12015 18479 14783 13857 12928 71520 20846 17475 20848 16797 16331 215280 18708 20851 56792 667739 56468 11350 17179 17342 26395 16452 56717 56637 16590 16453 23921 BIOCARTA_IL5_PATHWAY%MSIGDB_C2%BIOCARTA_IL5_PATHWAY BIOCARTA_IL5_PATHWAY 16193 16176 16192 16191 14968 20292 12771 14969 12504 16189 HALLMARK_G2M_CHECKPOINT%MSIGDB_C2%HALLMARK_G2M_CHECKPOINT HALLMARK_G2M_CHECKPOINT 15260 56403 268996 13557 22036 17865 75717 68278 17219 17215 100039535 18817 20588 17127 52033 11991 17765 56275 19290 17536 20382 17268 20496 51810 209448 18973 71375 99375 238247 27374 13486 19704 27214 17218 13555 21781 50927 77782 15354 20842 100039474 17345 12412 12567 65964 23834 68612 26429 12449 104394 15366 72391 107823 56452 20873 20460 12576 272551 21915 17216 30939 56150 14056 19357 626954 21887 14105 212999 19359 20641 27041 15251 13405 16765 18263 20937 71819 21803 16211 73804 209737 14211 100039592 20877 72119 70099 67052 20878 12235 16319 17750 26554 12615 107503 21335 23924 18472 103573 17420 21973 101706 26934 11350 18854 11987 54124 19650 12190 24061 15574 15481 18005 12580 60406 14088 12530 12442 108000 12534 73086 15270 12531 17118 26885 51788 26965 18129 13640 19891 12428 13645 14852 19076 16201 105727 76464 13018 21917 18141 26909 16906 16882 15374 27221 12545 98386 19134 19366 21969 20539 22589 12455 80914 22427 78733 20462 231386 234852 319181 245474 210106 242705 226525 14030 229841 12021 67956 108907 110033 12649 233406 11799 67141 240641 107995 105988 16571 15361 12237 70769 22137 217232 18969 16551 12051 26416 100710 110809 12544 71514 17869 16573 12443 20775 PID_E2F_PATHWAY%MSIGDB_C2%PID_E2F_PATHWAY PID_E2F_PATHWAY 13557 17865 17215 22294 17210 12448 20135 20859 12369 67935 73389 52679 56353 27374 13555 21781 19650 23834 12580 104394 12530 12534 12576 12428 13559 19385 19646 15248 18392 19651 12419 83767 12447 225182 12566 12445 19645 13361 100683 14534 22594 50496 235559 18968 20133 21877 104158 211586 22171 13909 18519 433759 234677 21849 67155 242705 436059 209446 12578 20683 11920 93759 11783 22062 12914 12606 18787 12575 18792 17869 12189 328572 22632 ST_GAQ_PATHWAY%MSIGDB_C2%ST_GAQ_PATHWAY ST_GAQ_PATHWAY 16439 18806 18807 228550 18035 18036 110355 18805 14682 228026 14962 11652 16438 110094 23797 11651 16440 320404 18033 74769 16151 13138 18038 18037 72749 18034 18741 PID_MTOR_4PATHWAY%MSIGDB_C2%PID_MTOR_4PATHWAY PID_MTOR_4PATHWAY 18806 18805 11651 73826 26417 51897 22241 22627 18854 18569 56430 68441 74370 67605 670717 55948 20787 12421 19353 245670 11848 109270 52187 227743 19303 54170 16150 74747 106298 100042570 29869 18750 110157 15461 20111 100039786 109880 16367 78757 22084 12447 26395 26396 12566 19017 22628 243369 22631 54401 13684 13681 18607 13631 13629 26413 75705 13685 64930 103583 56717 20393 56716 22629 18176 97998 16653 22632 PID_IL8_CXCR2_PATHWAY%MSIGDB_C2%PID_IL8_CXCR2_PATHWAY PID_IL8_CXCR2_PATHWAY 18750 18806 11651 18607 19052 104709 14702 51792 94176 19354 17096 109689 14688 30955 22323 12765 216869 271457 14675 13429 18751 14191 140580 14676 18797 15162 18796 12402 18752 18795 53869 19349 14678 PID_CONE_PATHWAY%MSIGDB_C2%PID_CONE_PATHWAY PID_CONE_PATHWAY 110855 77974 14695 245650 78600 19682 30952 79235 243923 170735 14913 12790 107477 19739 14686 14697 14710 19892 14919 76376 24013 BIOCARTA_TALL1_PATHWAY%MSIGDB_C2%BIOCARTA_TALL1_PATHWAY BIOCARTA_TALL1_PATHWAY 53859 21935 57916 24099 69583 72049 22031 22033 22030 19697 26419 22034 12675 26416 18033 PID_GMCSF_PATHWAY%MSIGDB_C2%PID_GMCSF_PATHWAY PID_GMCSF_PATHWAY 110157 15461 26395 26396 22631 18749 20848 16331 14389 19247 18747 26413 14281 12984 12981 16452 20846 20416 12700 20850 18176 20851 20662 18413 12982 26417 20963 18712 20293 15900 17096 18708 16653 18706 16150 14784 PID_NEPHRIN_NEPH1_PATHWAY%MSIGDB_C2%PID_NEPHRIN_NEPH1_PATHWAY PID_NEPHRIN_NEPH1_PATHWAY 26419 11651 74769 26420 18708 18710 26414 18709 18762 12015 17973 216869 19353 170484 12488 54631 170643 26398 17974 18803 18759 18706 14064 22068 21872 14360 56513 73178 16476 14784 18707 HALLMARK_PEROXISOME%MSIGDB_C2%HALLMARK_PEROXISOME HALLMARK_PEROXISOME 20588 76524 12908 51797 74754 20280 15926 66307 56752 13870 18458 26874 13850 76267 20148 12572 20479 20238 13385 76263 18670 12287 66887 54725 13370 20524 19302 269951 73836 18631 72129 12359 18477 13872 51798 319554 17685 18171 667310 14081 11739 74147 17252 15488 56273 54200 12042 20656 110196 18632 26458 22139 12401 20927 12613 20183 11657 54338 16413 19305 15925 110959 54683 66437 13016 12904 12903 26889 15484 100559 78388 20437 67283 12257 50790 22287 67442 21973 11430 433256 16204 56325 170789 23986 113868 68801 56185 11668 27416 18671 114664 56690 20348 15356 13983 11666 224824 14712 12785 19299 101502 15461 22629 PID_ERA_GENOMIC_PATHWAY%MSIGDB_C2%PID_ERA_GENOMIC_PATHWAY PID_ERA_GENOMIC_PATHWAY 12675 13983 16476 22192 12034 18002 18538 22200 268527 12006 55960 78330 224903 114604 67488 268395 100041004 22433 66949 12608 69191 13508 18997 23957 212391 15500 211329 11957 433759 12266 27410 20850 67040 11764 18667 11785 20602 17128 18996 16911 12521 116870 17979 13033 19014 671392 17978 208727 17977 11737 20185 13982 24068 19109 71990 12822 667310 11614 268903 17869 12189 328572 12443 PID_ARF_3PATHWAY%MSIGDB_C2%PID_ARF_3PATHWAY PID_ARF_3PATHWAY 76932 18806 107338 12757 12504 19353 11773 56041 260302 56494 11771 13196 74325 11840 68137 18720 12847 228998 19158 PID_ECADHERIN_NASCENT_AJ_PATHWAY%MSIGDB_C2%PID_ECADHERIN_NASCENT_AJ_PATHWAY PID_ECADHERIN_NASCENT_AJ_PATHWAY 16407 50884 13000 12387 12928 100039026 12550 18717 29875 21844 76884 11308 13043 11767 17356 226541 11651 13001 11845 242687 16421 13383 22325 18708 19353 11848 18706 107746 109905 21872 12388 18102 20779 215449 16480 12443 12385 BIOCARTA_CACAM_PATHWAY%MSIGDB_C2%BIOCARTA_CACAM_PATHWAY BIOCARTA_CACAM_PATHWAY 55984 12322 108058 12323 12325 640703 215303 12326 12912 52163 207565 BIOCARTA_MYOSIN_PATHWAY%MSIGDB_C2%BIOCARTA_MYOSIN_PATHWAY BIOCARTA_MYOSIN_PATHWAY 18750 14682 71704 102098 17898 54126 16801 213649 442801 230972 14688 19877 107589 236915 69632 11855 17906 329251 18751 14699 16800 213498 14674 207212 14673 18795 234094 320795 226970 73341 HALLMARK_CHOLESTEROL_HOMEOSTASIS%MSIGDB_C2%HALLMARK_CHOLESTEROL_HOMEOSTASIS HALLMARK_CHOLESTEROL_HOMEOSTASIS 12387 107503 60525 18030 20788 19016 16854 14677 50762 22038 27279 69590 228775 63913 54140 66102 11910 74155 100040592 236900 12759 19141 60599 20195 16592 11658 11747 69787 13121 11676 231207 12527 104174 11305 20239 69071 56389 170459 16956 105853 14137 71914 15490 68671 56473 15357 17855 235293 14104 13595 73166 192156 16987 18194 108767 13360 12660 51798 110006 18793 319554 12411 66071 26876 20347 11465 68603 20249 16449 68312 16835 110460 110196 20775 SA_G1_AND_S_PHASES%MSIGDB_C2%SA_G1_AND_S_PHASES SA_G1_AND_S_PHASES 13555 12566 12567 12578 11842 12631 17246 12576 56488 11840 22059 12575 667929 12443 242705 BIOCARTA_MPR_PATHWAY%MSIGDB_C2%BIOCARTA_MPR_PATHWAY BIOCARTA_MPR_PATHWAY 15461 20111 18749 26413 18667 26417 14688 11459 19088 71904 17932 19084 19087 19085 432530 23988 66713 12331 74090 14699 56443 12534 76709 68089 67771 14677 20779 12532 56378 74117 11867 BIOCARTA_IL12_PATHWAY%MSIGDB_C2%BIOCARTA_IL12_PATHWAY BIOCARTA_IL12_PATHWAY 16162 15978 16161 26399 104156 12766 16182 20849 26419 12774 26416 12500 12501 16452 12502 16160 12503 16173 16476 16159 54721 BIOCARTA_AT1R_PATHWAY%MSIGDB_C2%BIOCARTA_AT1R_PATHWAY BIOCARTA_AT1R_PATHWAY 18750 110157 15461 11606 14682 26401 26395 26396 26419 19229 11607 17260 17258 13649 11909 18479 640703 14083 26413 17261 13712 20416 20662 26417 19353 26398 18751 20779 16476 14784 BIOCARTA_CHEMICAL_PATHWAY%MSIGDB_C2%BIOCARTA_CHEMICAL_PATHWAY BIOCARTA_CHEMICAL_PATHWAY 18750 13665 12368 12043 12122 11545 12028 21894 670717 12015 12048 12367 12371 11651 18751 11920 14083 11783 12369 19303 22059 20846 BIOCARTA_CXCR4_PATHWAY%MSIGDB_C2%BIOCARTA_CXCR4_PATHWAY BIOCARTA_CXCR4_PATHWAY 18750 26417 110157 15461 12928 18705 18708 14688 14682 19697 26395 19229 18751 14699 18803 14083 26413 18706 14677 19303 18033 12767 20315 12927 HALLMARK_KRAS_SIGNALING_DN%MSIGDB_C2%HALLMARK_KRAS_SIGNALING_DN HALLMARK_KRAS_SIGNALING_DN 16191 15484 100559 22287 13645 12021 16848 110308 259277 67426 110935 15061 58185 13176 21954 20429 20621 16426 93735 21415 12427 19271 18125 16678 72350 56632 19065 27413 18772 18604 53422 21816 19220 54371 22094 217847 13072 232370 114141 21834 404634 235320 50782 60345 109791 70239 93685 12824 18429 12227 104271 17687 54631 246133 232821 213417 56358 18440 16370 67861 98682 21819 102954 21785 16506 20608 20503 18566 208922 11553 14536 23964 15551 13162 56711 66106 73647 21432 18506 14748 20665 22363 12299 54652 14804 21908 74100 98363 140781 57745 21419 11944 73288 114479 64242 18587 17910 68916 67747 117589 14184 12310 93872 20754 227541 20743 14308 20264 12556 13528 320007 20363 57253 18948 12804 57385 11464 106565 84036 19127 14760 16858 71279 100647 19125 16533 50878 70355 15932 13608 546071 15552 106369 66972 104069 114642 16682 54634 381022 17769 80796 56774 58916 20497 26549 76703 104027 232680 12776 76257 16536 23993 232078 67133 246278 12519 16663 16665 14570 11698 21947 56050 13614 50873 14723 53883 16008 21405 21808 18788 81879 12715 192663 67112 14431 80903 20482 20190 72434 15139 22784 23919 11686 18205 54483 13839 54420 11449 14573 12167 20191 18505 13615 18227 16160 20393 15978 BIOCARTA_IL4_PATHWAY%MSIGDB_C2%BIOCARTA_IL4_PATHWAY BIOCARTA_IL4_PATHWAY 16367 16451 16190 16453 20852 20416 16186 14784 16189 11651 BIOCARTA_TCR_PATHWAY%MSIGDB_C2%BIOCARTA_TCR_PATHWAY BIOCARTA_TCR_PATHWAY 18750 110157 15461 18035 26401 26395 19697 26419 640703 14281 13712 12500 12501 18033 12502 20416 12503 20662 16818 26417 22637 18019 18018 320139 218397 16797 18708 73181 19057 30955 19055 19056 22324 19353 18021 26398 18751 18803 18706 14360 16476 14784 BIOCARTA_G2_PATHWAY%MSIGDB_C2%BIOCARTA_G2_PATHWAY BIOCARTA_G2_PATHWAY 20111 100039786 12649 17932 18817 12530 11920 12534 12531 17246 19090 216150 22059 50883 12575 13197 12532 12189 22629 328572 100043858 22390 BIOCARTA_NO1_PATHWAY%MSIGDB_C2%BIOCARTA_NO1_PATHWAY BIOCARTA_NO1_PATHWAY 11435 12062 18127 14254 16542 21952 12389 14257 18576 22339 385643 15519 12669 54611 207728 11651 18749 640703 19091 19092 11987 11459 19088 19084 19087 19085 20191 BIOCARTA_GRANULOCYTES_PATHWAY%MSIGDB_C2%BIOCARTA_GRANULOCYTES_PATHWAY BIOCARTA_GRANULOCYTES_PATHWAY 15978 20345 15139 16408 16409 20343 21926 16414 12985 18613 16175 20344 15894 PID_ECADHERIN_KERATINOCYTE_PATHWAY%MSIGDB_C2%PID_ECADHERIN_KERATINOCYTE_PATHWAY PID_ECADHERIN_KERATINOCYTE_PATHWAY 12387 12550 18708 22323 11652 19353 11651 11848 13649 18803 18706 14360 22793 12388 16475 20779 18720 12374 16480 12385 ST_TYPE_I_INTERFERON_PATHWAY%MSIGDB_C2%ST_TYPE_I_INTERFERON_PATHWAY ST_TYPE_I_INTERFERON_PATHWAY 15977 16391 19273 19692 15975 16451 20846 20847 54721 ST_GA13_PATHWAY%MSIGDB_C2%ST_GA13_PATHWAY ST_GA13_PATHWAY 18806 18807 12043 18035 18036 18805 228026 26401 26419 14962 11652 110094 23797 11651 19684 20807 26408 14083 18033 74769 19878 16151 18760 21390 13385 19877 26398 18038 18037 72749 18034 213498 14674 BIOCARTA_PITX2_PATHWAY%MSIGDB_C2%BIOCARTA_PITX2_PATHWAY BIOCARTA_PITX2_PATHWAY 12387 19014 100683 16842 22408 11789 12914 18741 13542 12005 14362 433759 56637 328572 16825 PID_RAC1_PATHWAY%MSIGDB_C2%PID_RAC1_PATHWAY PID_RAC1_PATHWAY 50884 12387 12928 12550 18717 29875 76884 26419 11308 242687 26934 17969 241275 13057 71893 192662 329165 26420 26400 18719 108100 237038 404710 26397 17970 11855 224105 16885 19353 26398 26403 18720 16476 13058 12927 101314 83767 26401 20848 11909 18479 20850 26399 66713 76709 68089 12631 26416 67771 18796 56378 74117 11867 12385 PID_TRAIL_PATHWAY%MSIGDB_C2%PID_TRAIL_PATHWAY PID_TRAIL_PATHWAY 26417 18708 18710 22030 26401 18709 26419 12370 71609 12633 12675 22035 14082 19766 26398 21933 20597 26413 65111 18706 16150 74769 16151 18707 PID_P53_REGULATION_PATHWAY%MSIGDB_C2%PID_P53_REGULATION_PATHWAY PID_P53_REGULATION_PATHWAY 26419 11651 26374 67025 27401 70425 93687 104318 53892 27373 216080 73251 17248 226830 27374 18753 11350 26420 56637 12428 18002 12566 18519 21849 19052 103236 252870 13163 214897 67956 68098 65019 59026 12649 15258 67773 333654 12450 69181 110750 100043295 13560 225055 23988 110854 12578 81601 219022 11920 12914 26416 17246 22059 50883 328572 22632 PID_ALPHA_SYNUCLEIN_PATHWAY%MSIGDB_C2%PID_ALPHA_SYNUCLEIN_PATHWAY PID_ALPHA_SYNUCLEIN_PATHWAY 22223 18806 30931 109731 14773 57320 13162 100039026 56424 21823 18805 12143 22612 20617 22195 19229 67847 26413 19144 21770 18753 50873 14225 16818 26417 20963 17096 12015 14191 15162 18796 14360 20779 BIOCARTA_SODD_PATHWAY%MSIGDB_C2%BIOCARTA_SODD_PATHWAY BIOCARTA_SODD_PATHWAY 14082 19766 21938 21926 22030 11796 12370 71609 67384 21937 PID_CMYB_PATHWAY%MSIGDB_C2%PID_CMYB_PATHWAY PID_CMYB_PATHWAY 29875 12427 23871 23872 12490 18712 18507 17523 11906 11541 15481 16842 22408 12576 51788 12847 17311 12368 12609 12043 18099 15461 17863 12757 19208 17217 20466 15205 19225 50701 229615 20481 17878 67972 12418 67738 64050 26409 16841 19152 12608 19374 12346 14460 56463 17927 18674 17120 545878 14863 11486 21849 232087 67155 18176 21426 15258 12504 19055 20185 22761 12578 20683 16653 14462 17132 16590 12914 16790 66513 12606 11796 12575 68652 12978 17869 20375 12571 328572 12443 12843 22196 PID_AR_PATHWAY%MSIGDB_C2%PID_AR_PATHWAY PID_AR_PATHWAY 15382 59004 56705 12387 22215 56406 21413 114774 627557 110651 59035 12537 75273 12370 56469 227753 21815 11651 14200 11835 57257 22596 215114 14375 72993 227292 225115 50523 232286 14228 76804 18813 104263 18095 50528 99982 17152 56218 328365 21804 84704 75502 57908 22200 229615 19229 12445 20807 19014 17978 18477 12578 268903 19090 12189 12571 12443 22196 BIOCARTA_RANKL_PATHWAY%MSIGDB_C2%BIOCARTA_RANKL_PATHWAY BIOCARTA_RANKL_PATHWAY 19697 26419 22034 15977 16391 14281 15975 15976 21943 18033 21934 14283 14284 19106 BIOCARTA_HDAC_PATHWAY%MSIGDB_C2%BIOCARTA_HDAC_PATHWAY BIOCARTA_HDAC_PATHWAY 17260 11651 16000 17258 23939 16334 16001 640703 16337 17261 215303 104248 17927 52163 22629 15184 18019 26399 18018 18708 19057 30955 19055 19056 18706 26416 SIG_CD40PATHWAYMAP%MSIGDB_C2%SIG_CD40PATHWAYMAP SIG_CD40PATHWAYMAP 18035 18036 22031 22033 22030 26419 22034 19252 26413 26415 19094 21939 18033 30957 74498 20979 60597 19099 16151 29857 17165 26417 26420 26400 18708 26414 26398 18038 18037 72749 18034 18706 26416 18707 BIOCARTA_LEPTIN_PATHWAY%MSIGDB_C2%BIOCARTA_LEPTIN_PATHWAY BIOCARTA_LEPTIN_PATHWAY 16847 105787 108079 16846 108097 19079 108099 107476 12894 241113 19082 BIOCARTA_AGPCR_PATHWAY%MSIGDB_C2%BIOCARTA_AGPCR_PATHWAY BIOCARTA_AGPCR_PATHWAY 18750 18749 18751 14699 109689 14688 19088 19084 19087 19085 14772 PID_TCR_CALCIUM_PATHWAY%MSIGDB_C2%PID_TCR_CALCIUM_PATHWAY PID_TCR_CALCIUM_PATHWAY 381319 16184 14103 16183 56398 16477 19058 18986 19225 53901 238276 54720 18747 14281 104248 12981 21947 14283 14225 15978 18019 18018 19055 19056 18021 16476 16189 PID_EPO_PATHWAY%MSIGDB_C2%PID_EPO_PATHWAY PID_EPO_PATHWAY 12043 15461 26419 12048 16331 19247 16452 20846 18033 20416 20850 20851 22325 20662 17096 18708 21682 18803 16923 12702 26416 12929 107746 22068 234779 109905 12229 12402 14388 384783 13857 15170 13856 14784 PID_TGFBR_PATHWAY%MSIGDB_C2%PID_TGFBR_PATHWAY PID_TGFBR_PATHWAY 12387 21803 17127 240025 12322 22601 16396 93836 20742 67068 20901 107568 13132 14225 21808 18854 22627 20482 11848 12005 56513 14784 12389 26409 18607 20416 20662 19052 71978 73122 13163 83814 17128 19053 21812 21813 21809 21814 11798 229317 17872 19045 218441 66313 230597 216869 68010 14219 75788 17131 17126 66513 68652 BIOCARTA_PS1_PATHWAY%MSIGDB_C2%BIOCARTA_PS1_PATHWAY BIOCARTA_PS1_PATHWAY 21405 12387 19164 11491 19664 13388 18128 22408 12234 11789 13542 12005 14362 56637 PID_AURORA_B_PATHWAY%MSIGDB_C2%PID_AURORA_B_PATHWAY PID_AURORA_B_PATHWAY 67455 28114 18148 16765 14020 23980 19348 71819 320165 12419 68298 215387 73804 19047 242521 14211 13346 22352 20877 54204 19167 70099 52276 67052 20878 12235 16319 26554 12615 72415 21770 26934 218397 11799 107589 11848 PID_DELTA_NP63_PATHWAY%MSIGDB_C2%PID_DELTA_NP63_PATHWAY PID_DELTA_NP63_PATHWAY 12609 12062 110308 15205 21415 18128 73389 22601 16396 21973 11486 107568 14284 18987 14104 22337 12190 14694 16664 55948 226849 16400 50754 64058 12578 211323 12442 72433 13395 11920 20997 12831 16009 16175 22061 17246 56437 17535 20913 56637 14776 26362 15201 56436 67815 PID_ANGIOPOIETIN_RECEPTOR_PATHWAY%MSIGDB_C2%PID_ANGIOPOIETIN_RECEPTOR_PATHWAY PID_ANGIOPOIETIN_RECEPTOR_PATHWAY 18806 12928 19697 26419 11651 18033 17390 23871 14173 26417 56458 13449 11601 14061 50915 14159 18708 17973 14786 19353 18706 19303 14360 14784 18127 11607 231130 69257 11600 12169 19247 18479 18815 26413 14083 16402 16412 13712 14268 20416 13709 20850 21687 20851 11602 218397 21926 26416 12575 SA_FAS_SIGNALING%MSIGDB_C2%SA_FAS_SIGNALING SA_FAS_SIGNALING 14103 12043 12631 18582 14102 12370 12367 12633 19011 PID_ANTHRAX_PATHWAY%MSIGDB_C2%PID_ANTHRAX_PATHWAY PID_ANTHRAX_PATHWAY 18667 16176 71914 26417 26399 12362 195046 26400 26395 26396 26397 26398 21926 26413 22329 69538 16173 SA_CASPASE_CASCADE%MSIGDB_C2%SA_CASPASE_CASCADE SA_CASPASE_CASCADE 13368 13347 11797 14103 235623 11545 14939 18646 11798 12370 20787 12367 12371 20788 11783 12369 14102 11796 PID_INSULIN_PATHWAY%MSIGDB_C2%PID_INSULIN_PATHWAY PID_INSULIN_PATHWAY 15461 12928 16367 12389 107371 14783 69940 11652 105504 19262 20411 19246 56484 11651 16331 16334 18607 19247 16337 13685 20393 20416 20662 218397 50915 18708 18762 17973 104215 13448 66482 20336 17974 53413 106628 18759 211446 18706 23921 14064 107746 12402 56513 14784 BIOCARTA_RHO_PATHWAY%MSIGDB_C2%BIOCARTA_RHO_PATHWAY BIOCARTA_RHO_PATHWAY 21894 227753 16801 18719 108100 19877 107589 11855 17906 16885 329251 11848 66713 56443 76709 68089 12631 67771 213498 18643 228359 22330 18720 20779 94190 56378 11856 74117 13367 11867 171207 PID_EPHRINB_REV_PATHWAY%MSIGDB_C2%PID_EPHRINB_REV_PATHWAY PID_EPHRINB_REV_PATHWAY 12143 22612 21844 26419 26409 16818 110135 50780 13844 14161 99571 270190 13642 17096 18708 13641 19249 16416 19353 16399 13429 26398 17974 14191 18706 15162 13846 14360 20779 12767 PID_UPA_UPAR_PATHWAY%MSIGDB_C2%PID_UPA_UPAR_PATHWAY PID_UPA_UPAR_PATHWAY 12928 21803 50701 56640 14756 13649 71785 14289 76701 18815 16402 17386 16412 22370 14268 17395 16971 330662 15234 18596 22359 16410 16419 110135 14161 99571 13035 14294 14293 17381 17392 16416 16400 19353 16409 18793 16414 18787 18792 20779 12927 BIOCARTA_ACH_PATHWAY%MSIGDB_C2%BIOCARTA_ACH_PATHWAY BIOCARTA_ACH_PATHWAY 21752 11443 14103 18198 18708 30955 19229 12015 56484 11651 14083 18706 11449 20779 22629 19400 BIOCARTA_VIP_PATHWAY%MSIGDB_C2%BIOCARTA_VIP_PATHWAY BIOCARTA_VIP_PATHWAY 18019 22353 18018 22355 18035 13655 13654 14682 19057 26401 19697 19088 19055 19084 19087 19056 19085 12675 18749 18803 640703 18033 17869 PID_S1P_META_PATHWAY%MSIGDB_C2%PID_S1P_META_PATHWAY PID_S1P_META_PATHWAY 14687 14682 13611 14681 20698 94226 17250 20397 13609 81535 14679 14675 14739 14672 13610 56632 14676 14677 14674 14673 14678 PID_ECADHERIN_STABILIZATION_PATHWAY%MSIGDB_C2%PID_ECADHERIN_STABILIZATION_PATHWAY PID_ECADHERIN_STABILIZATION_PATHWAY 13645 50884 12387 12550 18717 76884 11308 17356 16000 13649 16001 22793 15234 11845 233765 20909 65970 17309 19877 22323 17973 17906 11848 20336 210126 17920 211446 69697 16582 17295 109711 12388 11828 13636 22330 216963 11830 13367 19294 12385 13836 PID_IL12_2PATHWAY%MSIGDB_C2%PID_IL12_2PATHWAY PID_IL12_2PATHWAY 19697 56632 18033 12526 16174 13813 20303 12010 16177 15284 26397 19698 192656 12525 16185 15007 18034 16184 14103 16183 14939 19058 57765 14938 12703 17873 23882 18126 20848 11909 12774 14281 12500 12501 16452 20846 12502 56717 16160 12503 20850 16173 16159 54721 16162 16818 15978 16176 16161 26399 14968 16182 20849 14969 12504 20852 16186 19055 19056 26416 19349 16189 PID_CXCR4_PATHWAY%MSIGDB_C2%PID_CXCR4_PATHWAY PID_CXCR4_PATHWAY 12928 14687 14681 170735 17395 16410 18708 18710 18709 18762 12015 14679 18706 14677 14674 14360 18707 20479 20848 16331 19247 16402 16412 16452 20846 20850 20851 14968 14969 12504 12631 110355 12143 22612 11651 16396 74769 56458 14694 16885 19353 16400 20847 11848 227743 19303 12767 20315 12927 19211 50778 320207 11852 64143 26385 94212 231637 78757 56085 116733 19229 18607 16404 18479 16398 14083 241226 16403 213119 12500 15239 12501 11853 56717 12502 319480 109700 12503 16401 56716 104099 12988 19264 16818 104709 14702 17096 14688 30955 216869 22324 13429 14191 18797 15162 18796 18795 20779 215449 15170 14678 HALLMARK_HEME_METABOLISM%MSIGDB_C2%HALLMARK_HEME_METABOLISM HALLMARK_HEME_METABOLISM 13034 18174 17859 627557 69632 12227 11828 14479 18115 17330 84585 56190 68875 13829 54484 17025 71946 22042 11656 12445 12349 27053 20525 78369 56484 21961 15129 22275 15288 22276 14151 12346 12892 14460 211586 228608 53378 21672 18519 208846 192657 109778 233016 74104 66171 14629 14651 57278 12177 14630 17896 229363 21399 18563 102857 12725 16784 20342 26570 104776 12359 64704 19746 19044 13828 20533 22228 18452 59028 59125 15191 11518 13030 269587 74334 71683 14958 26357 71538 71207 233489 19358 69754 67608 104015 15199 107566 20617 53415 12183 64898 11975 12380 219094 67216 20739 18022 23925 30805 56224 73046 11733 12234 74309 16596 22439 12215 98766 70026 70827 17169 19824 666468 14055 83429 71648 14755 18023 11519 14317 28199 17524 20741 26397 216635 19743 21349 56786 16599 66691 13349 15126 22782 67712 216739 213988 65246 140780 338523 67151 67182 66878 68591 226781 225849 66935 215814 21969 214601 12266 242705 68262 63828 224703 14664 12013 15467 66447 216781 78908 22173 56209 16909 66943 11433 83486 65107 242418 107747 14815 217232 110351 30945 52065 74136 383295 208638 12585 114893 72674 22344 13857 60611 214597 78938 PID_GLYPICAN_1PATHWAY%MSIGDB_C2%PID_GLYPICAN_1PATHWAY PID_GLYPICAN_1PATHWAY 14182 14254 19122 620395 21803 14733 20563 12143 22612 16772 11820 22339 11905 16818 14173 21808 21812 21813 21809 17096 211323 17126 14191 15162 14360 20779 PID_FANCONI_PATHWAY%MSIGDB_C2%PID_FANCONI_PATHWAY PID_FANCONI_PATHWAY 15205 12144 106344 243369 237211 72151 27354 208836 14087 235559 21975 237911 74335 69263 19360 330554 19718 103583 68275 69928 235610 100040608 19355 230484 67561 60534 19367 72775 19356 71885 104806 101831 67196 12649 67030 233826 12190 211651 15574 14088 11920 15270 17535 12189 19891 PID_FRA_PATHWAY%MSIGDB_C2%PID_FRA_PATHWAY PID_FRA_PATHWAY 18127 16477 17395 14283 14284 16193 17390 18019 18018 20293 16774 83995 11911 14609 18021 16878 13179 12578 15368 18793 21824 20683 17313 16478 22282 353170 192897 23857 18792 16476 328572 12843 12443 12428 BIOCARTA_CTCF_PATHWAY%MSIGDB_C2%BIOCARTA_CTCF_PATHWAY BIOCARTA_CTCF_PATHWAY 19211 19052 17128 21808 21812 21813 21809 21803 18708 21814 30955 12578 18706 12576 12518 17246 22059 56717 17129 15985 17869 17125 BIOCARTA_AKT_PATHWAY%MSIGDB_C2%BIOCARTA_AKT_PATHWAY BIOCARTA_AKT_PATHWAY 19052 14103 56458 18035 18708 30955 19697 15519 12015 12675 56484 12371 11651 18607 18706 18033 16150 54601 22629 16151 14600 BIOCARTA_SARS_PATHWAY%MSIGDB_C2%BIOCARTA_SARS_PATHWAY BIOCARTA_SARS_PATHWAY 76282 13684 16832 14113 16828 12715 26416 16790 16833 BIOCARTA_CTL_PATHWAY%MSIGDB_C2%BIOCARTA_CTL_PATHWAY BIOCARTA_CTL_PATHWAY 14103 14939 18646 12010 15007 16408 16414 12500 12501 14102 12502 12503 15894 PID_TNF_PATHWAY%MSIGDB_C2%PID_TNF_PATHWAY PID_TNF_PATHWAY 11797 22166 22029 12389 18412 18201 22030 67338 26401 19697 665113 27206 26412 26921 12370 399510 71609 228355 12675 26406 225028 21929 26409 20598 26408 11491 74256 18033 20846 16151 21938 26400 14694 18762 26397 67384 21937 14082 19766 20597 21926 18759 66513 11796 68652 16150 BIOCARTA_BAD_PATHWAY%MSIGDB_C2%BIOCARTA_BAD_PATHWAY BIOCARTA_BAD_PATHWAY 17311 26417 12043 20111 12028 18708 30955 19088 12015 19084 12048 19087 19085 432530 11651 16000 18749 16001 26413 16590 18706 12984 16188 22629 PID_BETA_CATENIN_NUC_PATHWAY%MSIGDB_C2%PID_BETA_CATENIN_NUC_PATHWAY PID_BETA_CATENIN_NUC_PATHWAY 21752 12387 21413 12550 13016 21415 16319 16678 11835 73389 17395 12326 103573 17390 22627 55948 16842 20997 18741 11789 26965 16476 100039786 12006 665113 22628 243369 22631 100683 54401 17877 17342 11513 12590 20583 21888 433759 81004 12444 73739 22629 99377 67772 14175 13380 21885 67087 14797 77578 20174 13544 234130 20586 15902 21886 17978 21414 21416 21372 16543 59024 80334 12578 18014 72693 17709 12592 12291 64406 17928 13003 16600 15182 17869 140486 21402 328572 12443 16007 PID_KIT_PATHWAY%MSIGDB_C2%PID_KIT_PATHWAY PID_KIT_PATHWAY 114716 19277 240752 56792 17179 114715 14158 26411 26419 11651 26417 18708 12015 18706 56637 14784 17311 19211 110157 12043 15461 14783 26395 26396 12703 56484 20848 18607 19247 17342 20583 16452 20846 20416 20850 20662 17096 22324 13448 21682 16923 16590 23921 12929 12914 12402 14388 13857 15170 17444 13856 BIOCARTA_CYTOKINE_PATHWAY%MSIGDB_C2%BIOCARTA_CYTOKINE_PATHWAY BIOCARTA_CYTOKINE_PATHWAY 16193 15978 16183 16191 230398 16171 16170 16153 16163 16168 16198 16992 15977 21926 16175 16160 16173 16159 16189 BIOCARTA_CREB_PATHWAY%MSIGDB_C2%BIOCARTA_CREB_PATHWAY BIOCARTA_CREB_PATHWAY 18750 15461 20111 11651 18749 12322 108058 12323 12325 26413 12912 20662 26417 18708 19088 19084 19087 19353 19085 432530 18751 73086 18706 26416 14784 BIOCARTA_MAPK_PATHWAY%MSIGDB_C2%BIOCARTA_MAPK_PATHWAY BIOCARTA_MAPK_PATHWAY 53859 18035 21803 26411 110651 22030 19697 26419 71609 12675 17164 23939 17347 17346 102626 50772 56613 225724 58988 53608 12912 26407 269881 18033 338372 23938 26405 71751 11836 76089 26417 21808 26404 26410 26420 20112 26400 17187 26414 26397 224105 19353 19766 26398 73086 16150 26403 16476 14784 110157 15461 20111 109880 26401 26395 26396 26412 26921 399510 17260 26406 225028 17258 26409 26408 11909 18479 26415 26413 14281 17261 13712 19094 20846 20416 29857 17165 13163 26399 21812 21809 20683 26416 12606 17869 BIOCARTA_ACE2_PATHWAY%MSIGDB_C2%BIOCARTA_ACE2_PATHWAY BIOCARTA_ACE2_PATHWAY 11609 11421 17228 11606 12829 12828 94216 11607 12830 100038824 70008 12826 12827 BIOCARTA_PPARA_PATHWAY%MSIGDB_C2%BIOCARTA_PPARA_PATHWAY BIOCARTA_PPARA_PATHWAY 18035 19697 16334 11430 26417 18708 193740 22259 12895 110074 14107 18590 18706 17436 12491 11807 13865 20181 11806 66419 16476 17684 19013 14080 18750 19225 19017 15519 19645 18126 18749 19252 26413 23957 20850 16956 20851 20602 30955 19088 19014 19084 19087 17977 19085 20185 24068 18751 20683 21926 268903 12914 74147 15488 17869 328572 BIOCARTA_EGFR_SMRTE_PATHWAY%MSIGDB_C2%BIOCARTA_EGFR_SMRTE_PATHWAY BIOCARTA_EGFR_SMRTE_PATHWAY 13645 13649 20602 21834 235320 26416 26401 26395 21833 20181 19401 HALLMARK_XENOBIOTIC_METABOLISM%MSIGDB_C2%HALLMARK_XENOBIOTIC_METABOLISM HALLMARK_XENOBIOTIC_METABOLISM 76884 16000 23872 21937 15368 12491 14080 12349 104158 228608 69071 233016 14629 18563 15902 18787 242585 16816 13849 109672 12401 19286 14865 109900 105349 20517 14873 12583 14261 64898 103149 27273 269378 12846 22436 14782 18107 66375 17750 54426 64008 19128 15378 104086 11522 14859 13110 67442 13076 11430 18984 14262 14058 71093 18104 11655 15486 68801 72082 67880 22235 93732 20300 14854 12035 64292 30924 14114 23972 11429 53328 13074 259301 18041 17155 22021 55927 50500 14450 110208 50997 67103 13809 223455 117147 67489 12780 20514 66841 246277 12499 16010 68021 18145 14528 12408 209027 19215 71706 20498 11670 68943 11432 66082 110213 20733 106648 19692 65963 80911 66397 13195 22271 29858 12944 11532 56720 74114 59083 66054 22361 52585 11529 108156 231103 14872 22173 11669 77337 225913 57436 19171 13202 67437 11816 17161 13982 56794 14711 110351 78038 13082 51793 11761 18618 19662 74134 15483 110172 14085 330817 16480 14411 22370 15900 16177 13836 100043508 76408 21366 13106 14377 15926 14121 56376 56752 234724 18081 15452 70789 26874 16424 85305 94175 16427 17195 11847 74142 59046 55942 18815 109821 29811 11846 11431 14415 14102 11938 72269 16006 108037 13077 14538 19015 12359 51798 14962 21808 12927 12368 HALLMARK_BILE_ACID_METABOLISM%MSIGDB_C2%HALLMARK_BILE_ACID_METABOLISM HALLMARK_BILE_ACID_METABOLISM 212503 11303 71382 67452 13124 13122 13123 26459 11611 11835 16890 17117 18634 19193 15112 15497 17999 208665 74043 18633 19298 67470 20181 11806 74754 20280 15926 66307 56752 26874 13850 76267 11305 19301 20238 27400 223920 76263 20186 56473 14630 111175 170442 66887 237320 13116 13370 27404 76184 269951 110784 73836 103737 18631 19659 72129 20522 12359 18400 217262 16922 29815 319554 63959 12161 28250 18171 18642 667310 14081 14149 56362 11304 14473 69129 15488 67993 71877 54200 13371 217265 12642 26458 22139 12401 20183 54338 54683 64008 16596 104086 67442 56050 433256 71648 81879 11668 192663 114664 56690 11666 224824 14712 19299 101502 18145 23957 27410 74114 16818 56794 14711 BIOCARTA_FEEDER_PATHWAY%MSIGDB_C2%BIOCARTA_FEEDER_PATHWAY BIOCARTA_FEEDER_PATHWAY 16548 72157 58866 21991 19309 110119 226413 110095 15275 ST_MYOCYTE_AD_PATHWAY%MSIGDB_C2%ST_MYOCYTE_AD_PATHWAY ST_MYOCYTE_AD_PATHWAY 16439 14682 14459 14962 212541 16438 11651 26413 16440 13138 13385 13844 20190 19353 11886 19288 11554 81601 12391 16521 16524 12796 16519 14677 11789 18741 BIOCARTA_P35ALZHEIMERS_PATHWAY%MSIGDB_C2%BIOCARTA_P35ALZHEIMERS_PATHWAY BIOCARTA_P35ALZHEIMERS_PATHWAY 19052 93687 104318 12568 11820 56637 12333 12569 69543 12336 BIOCARTA_TEL_PATHWAY%MSIGDB_C2%BIOCARTA_TEL_PATHWAY BIOCARTA_TEL_PATHWAY 19052 18750 21752 12043 21745 22596 14375 15519 19645 11651 13649 16653 16001 21951 21749 22059 20020 17869 HALLMARK_IL6_JAK_STAT3_SIGNALING%MSIGDB_C2%HALLMARK_IL6_JAK_STAT3_SIGNALING HALLMARK_IL6_JAK_STAT3_SIGNALING 21803 15945 12982 21938 16362 20310 18712 11482 50498 26410 12977 16196 56066 16177 20306 12475 56324 24088 56744 232345 17874 21937 20847 15368 12491 16476 14784 330122 17329 16184 12768 27279 320207 16326 15979 50905 15980 16994 16178 12703 16169 16164 19246 54635 21673 16847 57914 20848 23897 17000 16195 16391 19247 16199 16172 19692 94185 12527 15975 12984 16188 12494 12981 16155 14102 55985 20846 18414 19255 16401 12018 11479 12505 12986 54721 16193 16176 16161 16182 16190 16186 12804 16416 21926 12702 12402 PID_LIS1_PATHWAY%MSIGDB_C2%PID_LIS1_PATHWAY PID_LIS1_PATHWAY 17755 100039026 13424 100040603 29875 23924 18472 22359 21770 11350 22627 56430 19353 11848 18476 83431 16976 18221 12568 13131 19699 13193 12569 27226 12570 18475 BIOCARTA_CASPASE_PATHWAY%MSIGDB_C2%BIOCARTA_CASPASE_PATHWAY BIOCARTA_CASPASE_PATHWAY 13368 13347 12368 11797 11545 12362 14939 18646 11798 670717 16906 12370 12367 12371 16905 12366 12363 12369 11783 11857 16907 11796 PID_MAPK_TRK_PATHWAY%MSIGDB_C2%PID_MAPK_TRK_PATHWAY PID_MAPK_TRK_PATHWAY 110157 15461 20111 109880 26395 17260 17164 23939 20807 26413 14281 13712 12912 23938 26405 18753 18176 26417 26399 98878 19762 13653 19769 26397 18205 16653 193034 73086 26416 109905 12568 12569 215449 PID_RHOA_PATHWAY%MSIGDB_C2%PID_RHOA_PATHWAY PID_RHOA_PATHWAY 19211 18806 18717 18805 21894 26419 19684 20807 11909 14281 16412 19878 29857 12704 109333 20404 223701 26399 16886 22350 17931 18719 19877 11459 18762 26397 17698 320271 17906 105243 16885 20544 11848 26398 12631 14064 12576 22330 56513 18720 16476 320795 13367 16007 BIOCARTA_CELLCYCLE_PATHWAY%MSIGDB_C2%BIOCARTA_CELLCYCLE_PATHWAY BIOCARTA_CELLCYCLE_PATHWAY 13555 21781 12579 12447 19650 12566 12445 12567 19645 12580 12572 12427 12578 12530 12534 12576 12575 12444 12571 66671 100043858 12443 BIOCARTA_LYM_PATHWAY%MSIGDB_C2%BIOCARTA_LYM_PATHWAY BIOCARTA_LYM_PATHWAY 16408 20343 12490 16414 16412 18613 16175 22329 16401 15894 PID_IL6_7_PATHWAY%MSIGDB_C2%PID_IL6_7_PATHWAY PID_IL6_7_PATHWAY 12609 16477 16451 229615 12048 56469 11651 17210 20848 16195 14389 12608 19247 17342 14281 16194 19094 16452 21943 21857 20846 22027 12944 18753 16803 54721 20662 19267 16193 16362 56458 26399 99571 16911 18708 22324 232345 19353 26398 12702 18706 26416 15162 14388 17869 16476 14784 BIOCARTA_TRKA_PATHWAY%MSIGDB_C2%BIOCARTA_TRKA_PATHWAY BIOCARTA_TRKA_PATHWAY 18750 15461 18751 18803 18706 18708 18049 18211 20416 14784 11651 20662 BIOCARTA_AHSP_PATHWAY%MSIGDB_C2%BIOCARTA_AHSP_PATHWAY BIOCARTA_AHSP_PATHWAY 15129 22275 11655 15288 22276 14151 15122 12892 14460 17025 11656 BIOCARTA_TNFR1_PATHWAY%MSIGDB_C2%BIOCARTA_TNFR1_PATHWAY BIOCARTA_TNFR1_PATHWAY 13368 13347 11545 22030 26401 16906 26419 12370 19645 71609 12367 228355 12905 20740 26409 18479 224105 67384 21937 16905 14082 12366 19766 26398 21926 11857 16907 19090 16476 BIOCARTA_SHH_PATHWAY%MSIGDB_C2%BIOCARTA_SHH_PATHWAY BIOCARTA_SHH_PATHWAY 19088 19084 14633 19087 13549 19085 18749 319757 13548 14634 19206 24069 20423 14632 56637 BIOCARTA_VDR_PATHWAY%MSIGDB_C2%BIOCARTA_VDR_PATHWAY BIOCARTA_VDR_PATHWAY 20185 12914 17979 22084 59035 19014 20181 18519 433759 17978 328572 17977 BIOCARTA_EPHA4_PATHWAY%MSIGDB_C2%BIOCARTA_EPHA4_PATHWAY BIOCARTA_EPHA4_PATHWAY 270190 17096 16412 13838 11459 16728 14360 109700 20344 215449 PID_BMP_PATHWAY%MSIGDB_C2%PID_BMP_PATHWAY PID_BMP_PATHWAY 68799 12156 69585 12162 12168 17130 227720 69274 12166 12159 20481 26409 26413 17128 11798 17872 19045 227292 218441 66313 68010 75788 17131 12161 12622 12667 18121 66513 12167 244058 55994 17129 68652 56637 23892 19042 66042 17125 14313 11625 BIOCARTA_RB_PATHWAY%MSIGDB_C2%BIOCARTA_RB_PATHWAY BIOCARTA_RB_PATHWAY 12649 12566 12567 17932 19645 11920 12534 12531 26416 22059 12532 22629 22390 BIOCARTA_41BB_PATHWAY%MSIGDB_C2%BIOCARTA_41BB_PATHWAY BIOCARTA_41BB_PATHWAY 15978 16183 18035 22030 19697 26401 26419 399510 12675 26408 11909 21942 26416 18033 16150 16476 16189 BIOCARTA_BCELLSURVIVAL_PATHWAY%MSIGDB_C2%BIOCARTA_BCELLSURVIVAL_PATHWAY BIOCARTA_BCELLSURVIVAL_PATHWAY 18708 11798 11799 30955 12367 11651 16969 19708 16478 12464 12369 14281 18706 16412 56717 109700 HALLMARK_REACTIVE_OXIGEN_SPECIES_PATHWAY%MSIGDB_C2%HALLMARK_REACTIVE_OXIGEN_SPECIES_PATHWAY HALLMARK_REACTIVE_OXIGEN_SPECIES_PATHWAY 19122 17250 14782 100042503 14325 18104 54132 11758 11927 68576 17523 15369 26462 14159 56615 69367 17196 224432 108737 110265 67130 76650 53381 93692 22166 16477 21672 14629 226646 109815 14778 625249 14630 15242 16985 59041 216161 320495 56421 50493 14381 12359 112406 18477 13871 110854 667310 100043858 20656 BIOCARTA_CERAMIDE_PATHWAY%MSIGDB_C2%BIOCARTA_CERAMIDE_PATHWAY BIOCARTA_CERAMIDE_PATHWAY 26417 110157 12043 26926 12028 18201 22030 19697 26395 26401 670717 26419 12370 12015 71609 21937 14082 19766 26398 20597 26413 18033 HALLMARK_HYPOXIA%MSIGDB_C2%HALLMARK_HYPOXIA HALLMARK_HYPOXIA 18534 11717 12457 15931 17859 109042 16795 14733 216558 20856 52231 18591 14447 13808 12209 56174 66681 11977 83553 17748 26757 13527 17319 53412 76459 15211 15476 19285 30046 20893 14042 20855 14284 57444 107817 23871 13198 117592 20778 13358 56012 14385 56485 11541 18484 53374 17035 93691 17133 17423 14828 14422 20971 13179 16572 15368 18030 83397 21983 170750 22022 104263 20439 231507 21753 18451 12576 76238 18682 17886 56277 17684 52331 16833 15531 12577 13806 230163 18641 16828 14751 22346 13008 12032 22695 11520 11910 170768 74155 11535 14734 236900 14387 12870 19883 20525 15277 12306 18654 21929 15417 12111 13004 11676 14735 14936 20970 23849 17988 75785 15116 110611 216136 21817 16770 16193 12177 99929 11674 56421 20342 108767 103988 100043349 15529 18793 16322 20198 13638 18452 15937 22403 57875 18787 20527 12575 14066 21810 18770 18655 105785 16007 51795 54683 17750 60406 12389 22339 12778 16948 12226 74185 13807 50527 12452 635960 70186 14635 78889 68507 14815 72157 21991 19309 15275 18772 22359 54371 18712 13636 16476 21366 14121 56484 14281 16006 14538 54200 228026 19664 93692 52187 12831 16009 13615 74747 12767 18750 12368 12043 26401 19017 13649 19252 83814 21809 17872 14219 384783 PID_TXA2PATHWAY%MSIGDB_C2%PID_TXA2PATHWAY PID_TXA2PATHWAY 110355 12143 22612 14682 11651 170735 14697 18753 20963 16801 19877 18762 19353 11848 14672 14674 14360 14673 13645 18750 18127 320207 13649 18747 19091 19094 22329 21817 21390 16818 19222 20339 104709 26941 14702 17096 14688 30955 216869 14675 13429 18751 14191 14676 26416 15162 18796 18754 18752 18761 20779 18755 53869 15894 320129 14678 19214 NABA_SECRETED_FACTORS%MSIGDB_C2%NABA_SECRETED_FACTORS NABA_SECRETED_FACTORS 620395 230398 18591 16171 16170 16153 16163 16168 16198 16992 16000 16334 21943 16878 18590 17311 20195 18654 16193 14175 16176 16191 20292 16322 20198 57875 16189 14560 14561 14562 14563 229574 14256 21803 14168 83554 387510 230405 668304 14181 14174 72514 14176 22035 14178 71920 81701 353156 54156 54426 54394 381457 100042150 12919 14167 14166 14165 56636 80857 14169 13607 20311 215257 58181 257630 140806 54450 54448 93672 69677 17700 20300 18188 319909 27356 269878 30924 230971 230316 18119 14566 78405 12064 238057 239114 215274 56069 22408 234836 16325 16324 329244 16336 67933 242316 76527 15161 13645 326623 50930 216505 240873 54612 20319 71325 99681 268686 12309 22339 268935 64706 22423 22412 20203 109910 214058 320202 217738 15977 13590 20197 20200 20199 70417 20194 20196 67860 66166 19197 57349 20193 20129 320460 16963 278507 19109 215001 21926 22164 22410 12985 319922 22018 16175 16323 12165 16156 24099 69583 93735 71785 15234 20377 15945 18413 20890 22413 20310 20379 22409 20293 50498 22411 12977 22341 16196 14205 20303 20296 56066 14825 20306 56744 11705 21949 11839 13363 16147 15245 22416 22417 22414 22415 22420 22421 22418 22419 216795 22422 20201 14164 14172 64654 16002 22340 15235 20378 13019 14314 15200 21802 20312 17242 20202 23886 14170 14177 14179 11600 16181 14171 14180 12160 12154 19242 12981 20295 116849 21944 13874 26360 20304 11602 12223 12404 215378 56410 12405 12163 20297 240843 24117 110075 12155 83430 83961 70726 72713 11876 654812 12803 69121 20299 12161 21832 12931 57266 18183 56708 228942 20290 100039973 100038965 56221 56838 20302 320924 12156 12162 12159 20423 18049 14173 21808 11601 67112 80903 23919 211323 18205 14573 12667 20315 14313 330122 17329 14103 16183 16326 16994 54635 16846 55985 16160 16173 16159 15978 21809 13856 SA_TRKA_RECEPTOR%MSIGDB_C2%SA_TRKA_RECEPTOR SA_TRKA_RECEPTOR 15461 26395 26396 18053 11652 23797 11651 11848 18706 13712 18049 12575 18211 20416 14784 18707 20662 BIOCARTA_WNT_PATHWAY%MSIGDB_C2%BIOCARTA_WNT_PATHWAY BIOCARTA_WNT_PATHWAY 18099 12387 100039026 13016 26409 93687 104318 12234 433759 19015 19052 21885 17128 24117 14296 16842 22408 11789 12914 66513 13542 12005 14362 56637 17869 12443 HALLMARK_FATTY_ACID_METABOLISM%MSIGDB_C2%HALLMARK_FATTY_ACID_METABOLISM HALLMARK_FATTY_ACID_METABOLISM 66052 66925 66945 17448 20916 14194 17449 14571 20520 11370 13382 14447 56442 13808 66357 13118 14645 27354 15107 227095 56451 68738 15929 52538 17319 68465 11363 93747 671878 15360 15446 12896 12683 23945 11409 67460 70335 17001 16852 11671 17436 12491 76238 19013 14080 12908 16828 74754 15926 56752 17025 100040592 12349 22275 22276 12892 109778 15490 14104 11674 18194 51798 319554 14081 74147 17252 15488 110460 13849 18263 19286 12613 14261 50790 11522 67442 11430 13076 433256 170789 23986 113868 68801 11758 56185 11668 22235 114664 56690 15356 11429 12167 51788 66841 68021 12408 15519 12894 11792 13180 11670 381045 100040843 13177 14079 14373 19186 170718 14874 20194 229877 21743 216454 12972 12040 22629 171210 14555 56720 15108 12351 73724 11992 22361 23923 67956 18207 11529 15505 231086 13807 11754 78920 109857 20917 52683 57436 68263 15159 12353 270076 72479 17161 56791 12480 67397 14204 11832 14417 68728 20216 19270 18597 11364 98314 75624 11564 HALLMARK_ALLOGRAFT_REJECTION%MSIGDB_C2%HALLMARK_ALLOGRAFT_REJECTION HALLMARK_ALLOGRAFT_REJECTION 26411 12263 100042807 16170 16149 11308 16153 16163 16168 16198 15976 23871 16878 12518 50701 12445 26409 12444 16193 16176 14968 20292 12504 12578 12189 20375 16189 15251 21803 216080 12035 16324 14938 12703 18126 12988 19264 16818 22637 11785 16190 16186 19171 16408 21926 16414 12051 16323 16156 18102 15894 22030 16678 17395 20293 12526 12977 15900 16174 16196 20303 20296 12010 20306 192656 24088 17973 12525 56744 16185 15007 14939 18646 17195 14102 16452 20846 13874 20304 20299 100039973 12042 24015 13040 18148 226419 100040021 192176 50931 14469 22375 13244 276770 226414 21355 668144 17076 94062 11651 14423 234734 12332 14537 22376 17972 84544 12519 80719 76784 79221 21857 21897 14130 21947 16364 16423 16822 18636 21354 12772 14744 21838 21808 12487 23880 14061 104458 55944 56468 230861 20085 56501 67248 76846 17084 19073 11423 54390 142980 15002 21899 27220 77647 17086 13669 16428 12524 54698 50723 16150 15000 15001 170823 667803 54123 216799 17329 16184 14103 16643 12768 14062 16183 15979 15163 192187 93765 21356 14998 20452 15980 12516 16994 14991 14960 11480 12481 13649 12774 12500 12501 21939 55985 12502 16160 12503 16173 16159 15978 16161 12766 17096 20849 18751 12480 14191 18752 15170 BIOCARTA_BARRESTIN_SRC_PATHWAY%MSIGDB_C2%BIOCARTA_BARRESTIN_SRC_PATHWAY BIOCARTA_BARRESTIN_SRC_PATHWAY 110157 26417 15461 109689 14688 26395 26396 432530 13429 14699 26413 15162 18795 20779 HALLMARK_MYOGENESIS%MSIGDB_C2%HALLMARK_MYOGENESIS HALLMARK_MYOGENESIS 69253 16651 30948 80888 19122 16773 13845 16795 20399 20692 20856 21345 11820 13808 13867 227753 11489 11515 12825 11603 16000 226251 19245 12323 12017 13527 140570 19165 53412 17907 11568 12834 20657 52250 12819 20893 21987 30051 15184 29817 13682 17883 12373 21956 17898 17929 53311 56012 17885 24053 12955 21924 64383 107589 12709 97064 21953 21925 225115 17901 17906 21957 12827 76722 22004 14248 17879 59069 56188 14199 12491 11790 192897 15464 21955 13009 59011 17886 17967 54601 11937 216459 17930 24052 17913 30953 17189 20391 29856 71994 17884 12862 58226 16510 14077 12759 14387 17878 24131 19645 14613 21393 17897 12842 13400 18693 19293 17880 76954 56642 20973 15982 21679 14226 12835 12224 12372 12865 16511 20410 77559 93739 14778 14245 100732 17896 16985 77090 13143 17868 50795 18563 23796 102857 13644 19223 83679 18767 11636 54411 17928 22354 11474 11537 12575 20249 17532 11815 12554 11472 17882 13405 21803 18104 11435 12062 21952 17873 16404 68507 11443 14681 19309 20698 18125 16419 12391 16582 12908 13019 15200 12299 20411 140781 16412 11464 18642 14081 110196 13346 11652 20740 18128 14173 12715 20190 11423 16009 11449 14313 22084 17260 17258 17261 29857 11459 19769 NABA_CORE_MATRISOME%MSIGDB_C2%NABA_CORE_MATRISOME NABA_CORE_MATRISOME 16773 20563 20692 16772 12825 11603 11568 12834 12819 29817 12829 12828 94216 16774 12830 12826 12827 13179 17313 12032 12842 12111 13004 12835 67776 71768 328643 70853 69882 192199 232585 22403 27762 13003 21810 12843 16007 51795 239852 22787 22788 75718 18133 226519 22786 22371 80883 243967 57764 18209 170721 229389 18419 18302 50706 69675 18542 76477 17182 17181 17180 108075 216760 100034361 94111 17183 105450 338352 70945 76293 18074 68169 207596 54003 21827 26944 329278 21828 94242 21960 252974 21930 81877 14114 22283 240675 244152 233813 74199 246228 226866 228770 72780 239405 208777 64074 64075 20564 233744 13602 21684 21683 64817 140703 107581 14115 329941 280635 12837 16010 17304 68792 12840 407800 12821 216616 12841 100952 246707 13717 13601 12817 50530 12813 56429 12945 268780 58859 12814 16775 236790 382864 83691 78892 666279 50766 214425 16777 18073 68709 171508 12845 242603 76737 330470 73230 16997 16998 11704 12810 12836 21826 246316 56839 333088 242050 268977 12822 76905 243914 213469 665700 14456 235379 78919 75426 16012 16011 16005 224224 63859 15530 330790 67666 73940 14264 13406 242608 244550 27047 269120 236690 18295 16545 17022 70370 72902 94214 20745 53856 19074 22370 100689 116847 231470 68655 320181 234199 14190 14119 17150 23876 16779 12815 21923 114249 12833 14118 16780 16776 12818 12839 77018 12824 140709 20562 68588 12823 12816 11450 237759 245026 53867 213945 373864 69700 73368 13516 71690 71355 12950 66695 320712 12643 19387 22402 14268 15891 13612 18208 23928 16006 21825 16782 20750 12832 110135 14161 99571 11698 16008 19073 12831 16009 243369 14219 19699 PID_NFKAPPAB_CANONICAL_PATHWAY%MSIGDB_C2%PID_NFKAPPAB_CANONICAL_PATHWAY PID_NFKAPPAB_CANONICAL_PATHWAY 18750 11797 18035 111173 19384 257632 19697 66105 240354 22034 192656 243369 12675 21937 21929 11920 74256 21926 18033 103573 16150 12042 16151 PID_PDGFRB_PATHWAY%MSIGDB_C2%PID_PDGFRB_PATHWAY PID_PDGFRB_PATHWAY 50884 12928 29875 110651 21345 18591 20698 26419 76884 11308 13043 13609 17356 19271 16971 18596 242687 16410 22325 19106 26420 18708 18710 26414 18709 17973 26398 17974 16478 18803 18706 14360 73178 16476 14784 18707 14783 19246 20848 19247 14281 16452 20846 20416 20850 20851 20662 16416 13448 20491 20469 65962 13430 232906 98910 69710 12143 22612 60595 238130 214384 74769 13860 19341 18783 18753 72930 16706 11350 26417 192662 22627 26400 108100 55948 19353 11848 101314 12927 18750 19211 110157 15461 320207 100039786 109880 94212 26395 26396 22628 22631 54401 20807 18479 26413 13712 19255 22629 18176 12988 16818 19052 104709 26941 51792 218397 17096 30955 271457 23988 66713 16653 14191 76709 68089 67771 15162 107746 109905 14388 18754 12402 20779 17869 215449 56378 74117 11867 HALLMARK_INTERFERON_ALPHA_RESPONSE%MSIGDB_C2%HALLMARK_INTERFERON_ALPHA_RESPONSE HALLMARK_INTERFERON_ALPHA_RESPONSE 15061 14469 58185 22375 16149 12370 16168 19167 68487 317677 239739 55932 65972 16363 66355 19124 16423 57444 21354 19106 15945 16362 12977 16196 56066 12010 192656 20847 54123 80876 22038 67775 20821 17069 12362 23960 54199 209086 67138 231655 71586 100038882 109032 56338 667370 70110 99899 64685 547253 52668 22169 16391 73711 19186 72075 53312 211329 13709 17454 246696 231712 74481 12799 212943 74157 67168 80861 74735 16190 71701 80285 243771 22670 268749 19188 66988 74153 319236 20343 56791 15958 108670 217069 19039 16912 100121 66141 16913 56417 234311 69550 229003 24110 BIOCARTA_CLASSIC_PATHWAY%MSIGDB_C2%BIOCARTA_CLASSIC_PATHWAY BIOCARTA_CLASSIC_PATHWAY 12263 109828 12274 15139 625018 12262 12259 317677 667277 12260 230558 12279 12266 BIOCARTA_MCALPAIN_PATHWAY%MSIGDB_C2%BIOCARTA_MCALPAIN_PATHWAY BIOCARTA_MCALPAIN_PATHWAY 13645 26417 15461 12766 22350 21894 11459 19088 107589 19084 19087 19085 17906 18749 13649 26413 14083 16412 12334 19303 109700 12333 69543 12336 BIOCARTA_PYK2_PATHWAY%MSIGDB_C2%BIOCARTA_PYK2_PATHWAY BIOCARTA_PYK2_PATHWAY 18750 110157 15461 14682 26395 26401 26419 19229 26396 18479 640703 26413 20416 20662 26417 26397 19353 18751 26398 18803 26416 12929 20779 16476 14784 12927 PID_FAS_PATHWAY%MSIGDB_C2%PID_FAS_PATHWAY PID_FAS_PATHWAY 14103 11797 12122 26401 26419 12370 12367 12633 12675 11651 18607 19094 14102 74769 16151 20963 26399 26420 26400 22350 18708 18710 26414 18709 14082 19766 20597 19687 67300 18706 26416 11796 12229 16150 72393 20779 18707 HALLMARK_HEDGEHOG_SIGNALING%MSIGDB_C2%HALLMARK_HEDGEHOG_SIGNALING HALLMARK_HEDGEHOG_SIGNALING 16728 22339 19206 18815 20423 14632 22359 20254 18015 21838 23872 21885 319504 15214 18186 18854 22253 218397 15213 18187 21887 20562 12804 11423 12933 12934 12614 17886 14766 94190 16825 27494 12569 12571 104001 18096 PID_THROMBIN_PAR1_PATHWAY%MSIGDB_C2%PID_THROMBIN_PAR1_PATHWAY PID_THROMBIN_PAR1_PATHWAY 18750 18127 14062 13430 14687 14682 14681 22793 19878 18753 14702 192662 16801 14061 18708 109689 14688 75547 19877 22323 56440 67804 17906 14679 14675 11848 13429 18751 14672 18706 14676 14064 18797 14677 22068 14674 18796 14673 18752 18795 320795 320129 14678 BIOCARTA_EIF4_PATHWAY%MSIGDB_C2%BIOCARTA_EIF4_PATHWAY BIOCARTA_EIF4_PATHWAY 18750 19211 26417 16367 18708 230861 13690 18458 208643 11651 13684 13681 17346 18751 18607 26413 18706 26416 13685 18604 56717 13682 14600 BIOCARTA_FREE_PATHWAY%MSIGDB_C2%BIOCARTA_FREE_PATHWAY BIOCARTA_FREE_PATHWAY 22436 14782 21926 14775 667310 14854 237038 19697 18033 BIOCARTA_CK1_PATHWAY%MSIGDB_C2%BIOCARTA_CK1_PATHWAY BIOCARTA_CK1_PATHWAY 19052 19088 19045 19049 19055 19084 14816 19087 19085 13489 18749 13488 104318 12568 18795 12569 HALLMARK_NOTCH_SIGNALING%MSIGDB_C2%HALLMARK_NOTCH_SIGNALING HALLMARK_NOTCH_SIGNALING 18750 16848 15205 14534 18131 100039623 54613 100042305 13388 19165 18128 270118 56438 14367 14357 103583 56198 74198 14369 19015 207521 22413 109689 21416 60406 14362 26965 16449 22418 18129 21402 12443 PID_ERB_GENOMIC_PATHWAY%MSIGDB_C2%PID_ERB_GENOMIC_PATHWAY PID_ERB_GENOMIC_PATHWAY 22192 236193 18002 22200 17979 20586 13983 17978 17977 71990 11614 23957 20587 57376 12266 PID_HDAC_CLASSI_PATHWAY%MSIGDB_C2%PID_HDAC_CLASSI_PATHWAY PID_HDAC_CLASSI_PATHWAY 18035 19384 19697 79221 103573 18033 15184 27374 17187 64383 21937 60406 19016 17119 22025 68346 19646 15183 70465 30795 20466 216848 75387 21422 107932 64384 17191 243369 23942 229512 229542 20848 18747 14460 18519 433759 20602 208727 20185 22761 100041953 75788 20467 17131 19386 21926 170787 93759 14461 50721 209011 12914 234366 70315 232232 15182 15185 328572 56233 22632 17192 22196 245688 PID_HES_HEY_PATHWAY%MSIGDB_C2%PID_HES_HEY_PATHWAY PID_HES_HEY_PATHWAY 15251 17863 11545 16542 15205 225182 54720 14387 19645 13016 20848 108058 19664 11835 18128 270118 14460 17927 16452 433759 14465 11925 21885 14463 13555 20602 19213 15214 12393 17172 15213 11863 22160 12504 56381 17977 103806 20185 55927 12914 12576 21423 99982 15901 328572 22632 14600 ST_GA12_PATHWAY%MSIGDB_C2%ST_GA12_PATHWAY ST_GA12_PATHWAY 13385 18806 110157 13844 18807 14061 18805 19415 17876 18124 14962 26419 14063 14065 22324 23939 14083 26413 14064 12229 23938 20779 16476 BIOCARTA_RANMS_PATHWAY%MSIGDB_C2%BIOCARTA_RANMS_PATHWAY BIOCARTA_RANMS_PATHWAY 20878 19385 16211 19384 209737 100039592 100088 101706 72119 BIOCARTA_RNA_PATHWAY%MSIGDB_C2%BIOCARTA_RNA_PATHWAY BIOCARTA_RNA_PATHWAY 53859 13665 100037258 18035 67204 19697 18033 22059 12675 19106 PID_CXCR3_PATHWAY%MSIGDB_C2%PID_CXCR3_PATHWAY PID_CXCR3_PATHWAY 17329 110157 15461 14687 78757 26395 14681 26396 11651 18607 26413 19094 55985 56717 74769 56716 18176 15945 26417 14702 26399 12766 20292 18708 109689 18710 14688 56066 18709 26397 56744 14679 16408 13429 16653 16414 18706 26416 14677 227743 20779 18707 14678 PID_RB_1PATHWAY%MSIGDB_C2%PID_RB_1PATHWAY PID_RB_1PATHWAY 13557 20937 13016 27401 11350 13555 21781 21808 26420 21429 12715 21374 14312 270627 56321 12567 19660 13433 20390 14836 223922 104394 19016 17295 12576 18505 16476 12428 12609 110157 19646 15183 12447 12566 12445 19645 12418 17260 11909 12608 17342 17927 19094 12981 20587 433759 13709 12444 242705 19052 12393 20586 12578 93759 12914 26416 17246 12606 12575 20375 12571 328572 12443 BIOCARTA_DREAM_PATHWAY%MSIGDB_C2%BIOCARTA_DREAM_PATHWAY BIOCARTA_DREAM_PATHWAY 18749 26417 56461 18387 14281 12912 19088 20020 19084 19087 16476 19085 PID_TELOMERASE_PATHWAY%MSIGDB_C2%PID_TELOMERASE_PATHWAY PID_TELOMERASE_PATHWAY 21752 22215 21803 12144 17127 27354 11651 19360 15976 18033 19355 11350 98999 208084 26417 16362 19367 13555 22627 17187 22596 14375 15574 60406 20687 22431 57321 21750 21951 103677 12576 21749 17535 497652 28113 15381 11546 11819 16476 101185 72400 100043508 17119 13645 19646 16183 20466 15519 229512 13649 26413 14281 22427 56717 433759 245474 15978 100041953 13982 20467 20683 11920 15182 17869 12443 245688 PID_ERBB1_RECEPTOR_PROXIMAL_PATHWAY%MSIGDB_C2%PID_ERBB1_RECEPTOR_PROXIMAL_PATHWAY PID_ERBB1_RECEPTOR_PROXIMAL_PATHWAY 13645 15461 18717 21894 227753 19246 20848 13649 19247 18479 14083 26413 20846 20416 74769 18176 20662 26417 218397 18708 18710 18709 17973 14679 16653 17974 18803 18706 14677 14388 73178 20779 15170 14784 18707 BIOCARTA_G1_PATHWAY%MSIGDB_C2%BIOCARTA_G1_PATHWAY BIOCARTA_G1_PATHWAY 21803 12447 12566 19645 17127 13361 12427 27401 433759 11350 13555 21808 17128 21781 12579 21809 12567 12578 12530 11920 12534 12576 22059 12575 56637 12571 12443 PID_ALK2_PATHWAY%MSIGDB_C2%PID_ALK2_PATHWAY PID_ALK2_PATHWAY 11705 110542 21909 12162 17128 11477 12168 17129 55994 17125 14225 PID_INTEGRIN2_PATHWAY%MSIGDB_C2%PID_INTEGRIN2_PATHWAY PID_INTEGRIN2_PATHWAY 15896 16411 19123 385643 78369 100689 381924 22329 21947 12266 18791 83964 14131 14058 14723 16456 110135 21838 14161 99571 16408 16409 18793 16414 21810 18792 15894 16007 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES%MSIGDB_C2%SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES 19159 20528 93742 277360 20663 110651 13869 228026 12913 16332 11652 21981 70584 18481 214230 23797 11651 241656 16000 12912 22627 20112 55948 12015 224105 606496 16370 18706 14064 12576 17295 56637 56513 14784 18707 19211 320207 20111 100039786 16367 22084 12566 22628 12048 22631 19246 54401 56484 52668 18479 14083 64930 56717 16006 20416 22629 20662 13595 12578 70769 14388 384783 13197 17869 PID_NFKAPPAB_ATYPICAL_PATHWAY%MSIGDB_C2%PID_NFKAPPAB_ATYPICAL_PATHWAY PID_NFKAPPAB_ATYPICAL_PATHWAY 16818 20963 13000 18035 100039026 18708 19697 243369 216869 18706 12051 26416 19696 13001 18033 16150 20779 BIOCARTA_EPONFKB_PATHWAY%MSIGDB_C2%BIOCARTA_EPONFKB_PATHWAY BIOCARTA_EPONFKB_PATHWAY 15251 18035 11863 19697 16452 18033 12575 14810 13857 20656 13856 BIOCARTA_NTHI_PATHWAY%MSIGDB_C2%BIOCARTA_NTHI_PATHWAY BIOCARTA_NTHI_PATHWAY 53859 16176 17128 26399 18035 21812 21813 19697 26397 24088 17127 12675 17874 26409 14815 21926 19252 26416 12914 19094 18033 16150 328572 BIOCARTA_CARDIACEGF_PATHWAY%MSIGDB_C2%BIOCARTA_CARDIACEGF_PATHWAY BIOCARTA_CARDIACEGF_PATHWAY 13645 18750 15461 11606 19697 11607 11489 11848 13649 18751 18803 13618 14281 13617 18033 17869 16476 13614 ST_ERK1_ERK2_MAPK_PATHWAY%MSIGDB_C2%ST_ERK1_ERK2_MAPK_PATHWAY ST_ERK1_ERK2_MAPK_PATHWAY 20111 109880 22031 20663 110651 12913 26395 26396 17451 13684 75590 17347 17346 13631 100040260 26413 319520 67603 12912 23849 18033 20416 11836 20662 26417 26410 20112 12015 81601 109905 14784 ST_TUMOR_NECROSIS_FACTOR_PATHWAY%MSIGDB_C2%ST_TUMOR_NECROSIS_FACTOR_PATHWAY ST_TUMOR_NECROSIS_FACTOR_PATHWAY 11797 18035 18036 22030 12370 71609 12367 12633 26406 26409 21929 22026 19765 18033 16151 21938 15463 67384 21937 14082 19766 26398 18038 21926 18037 72749 18034 11796 16476 BIOCARTA_PAR1_PATHWAY%MSIGDB_C2%BIOCARTA_PAR1_PATHWAY BIOCARTA_PAR1_PATHWAY 18750 14062 14682 19229 26409 71704 102098 54126 16801 213649 14061 442801 18708 230972 14688 19877 30955 236915 69632 14065 432530 329251 11848 18751 14699 16800 18706 14677 213498 14674 207212 14673 18795 234094 226970 73341 ST_B_CELL_ANTIGEN_RECEPTOR%MSIGDB_C2%ST_B_CELL_ANTIGEN_RECEPTOR ST_B_CELL_ANTIGEN_RECEPTOR 110157 228550 18035 18036 20663 26395 26396 11652 21981 23797 11651 26413 320404 18033 20416 12988 13138 20662 20963 13844 17096 18708 54446 17060 110279 12015 12478 22324 18477 18038 18037 72749 18034 18706 234779 12229 14784 18707 PID_SMAD2_3PATHWAY%MSIGDB_C2%PID_SMAD2_3PATHWAY PID_SMAD2_3PATHWAY 59004 73122 26417 17128 227720 16211 69274 26401 100039592 227292 17127 218210 17126 26413 19042 22196 BIOCARTA_BLYMPHOCYTE_PATHWAY%MSIGDB_C2%BIOCARTA_BLYMPHOCYTE_PATHWAY BIOCARTA_BLYMPHOCYTE_PATHWAY 16408 16414 14968 12519 14969 21939 14130 12902 15894 19264 SA_MMP_CYTOKINE_CONNECTION%MSIGDB_C2%SA_MMP_CYTOKINE_CONNECTION SA_MMP_CYTOKINE_CONNECTION 16176 21938 11421 246256 20737 21808 12977 21803 21941 21937 21949 20343 21926 16194 12505 ST_GRANULE_CELL_SURVIVAL_PATHWAY%MSIGDB_C2%ST_GRANULE_CELL_SURVIVAL_PATHWAY ST_GRANULE_CELL_SURVIVAL_PATHWAY 228550 11545 14682 12913 26419 12367 26413 14281 12912 320404 30957 60597 19099 13138 223753 13844 26420 26400 14825 26414 12765 11886 26398 12796 11789 16476 BIOCARTA_STEM_PATHWAY%MSIGDB_C2%BIOCARTA_STEM_PATHWAY BIOCARTA_STEM_PATHWAY 16193 16191 16183 12977 16196 12504 12525 16198 12985 12981 16156 13856 16189 PID_TRKR_PATHWAY%MSIGDB_C2%PID_TRKR_PATHWAY PID_TRKR_PATHWAY 12928 17179 20399 21844 330662 18049 18211 11350 26417 18708 18762 18053 19353 11848 78405 18205 12064 18803 18759 18706 14784 15461 18412 100040603 26395 20848 14389 19247 26413 20416 18176 20662 94275 83814 327826 218397 107971 19417 83945 98878 19762 19769 13429 216148 20418 16653 140580 12929 107746 56212 109905 67903 14388 18212 18213 330914 17207 215449 56470 12443 23873 PID_AVB3_OPN_PATHWAY%MSIGDB_C2%PID_AVB3_OPN_PATHWAY PID_AVB3_OPN_PATHWAY 53859 18035 19697 26401 26419 19229 227753 12675 26413 57257 14281 17395 18033 19878 16410 20750 12505 17390 26417 20963 18708 19353 16416 11848 16202 18706 18792 18720 16476 12927 SIG_BCR_SIGNALING_PATHWAY%MSIGDB_C2%SIG_BCR_SIGNALING_PATHWAY SIG_BCR_SIGNALING_PATHWAY 16439 110157 12043 20663 26411 228026 11652 21981 16438 23797 11651 16331 26413 23957 16440 20416 12988 19264 13138 20662 26417 18019 20963 18018 17096 18708 19057 17060 110279 12902 12015 19055 19056 12478 22324 14252 606496 12520 12483 18706 14251 234779 12229 56637 14784 18707 BIOCARTA_IL10_PATHWAY%MSIGDB_C2%BIOCARTA_IL10_PATHWAY BIOCARTA_IL10_PATHWAY 16193 20849 16451 20852 16153 20847 15368 20848 21926 16154 16175 16155 20846 109778 20850 233016 20851 BIOCARTA_INTEGRIN_PATHWAY%MSIGDB_C2%BIOCARTA_INTEGRIN_PATHWAY BIOCARTA_INTEGRIN_PATHWAY 110157 15461 12389 21894 26395 26396 26419 21961 26413 14083 16412 22793 109700 20416 12988 20662 26417 19877 11459 110279 329251 11848 12929 107746 19303 109905 11474 109711 14360 22330 20779 12333 16476 11472 14784 69543 12336 12927 BIOCARTA_PLATELETAPP_PATHWAY%MSIGDB_C2%BIOCARTA_PLATELETAPP_PATHWAY BIOCARTA_PLATELETAPP_PATHWAY 14061 14071 12829 12828 11820 94216 12830 12826 12827 109821 18815 18787 18792 18791 PID_HIV_NEF_PATHWAY%MSIGDB_C2%PID_HIV_NEF_PATHWAY PID_HIV_NEF_PATHWAY 53859 13368 13347 12368 14103 12043 12122 18035 22029 22030 19697 26419 12370 71609 12367 12633 12675 12905 12371 26408 12369 14102 18033 12503 13163 26400 670717 67384 21937 14082 12366 19766 21926 11783 11796 PID_S1P_S1P3_PATHWAY%MSIGDB_C2%PID_S1P_S1P3_PATHWAY PID_S1P_S1P3_PATHWAY 14254 14687 14682 14681 18591 22339 13609 23797 11651 26413 16452 18596 16410 26417 16416 19353 14675 11848 14679 14739 14672 13610 14676 14677 14674 14673 12767 20779 14678 PID_CERAMIDE_PATHWAY%MSIGDB_C2%PID_CERAMIDE_PATHWAY PID_CERAMIDE_PATHWAY 13645 110157 12043 12122 18035 114774 12028 18201 22030 26401 26395 58994 19697 26396 23992 26419 19645 26921 12370 71609 12905 228355 11651 16000 26413 56632 18033 18753 16706 19106 26417 26926 13033 229317 670717 18762 12015 67384 21937 11886 14082 19766 26398 20597 21926 18590 11796 17869 HALLMARK_MYC_TARGETS_V1%MSIGDB_C2%HALLMARK_MYC_TARGETS_V1 HALLMARK_MYC_TARGETS_V1 15382 56403 17219 100042807 106344 20588 11991 20382 51810 230484 17218 21781 67204 14375 12567 110074 18813 15381 17216 56150 23996 67089 19385 14113 69719 16828 233870 15510 66235 17217 66942 11757 12566 66445 70316 26443 26444 57296 27366 103136 53607 27979 21454 20133 381760 100040029 12261 15982 67134 22171 18674 52530 26754 27966 68092 73192 21849 55949 74326 20174 19359 20641 27041 15191 15182 18655 107686 26441 19166 18263 69692 667618 433702 67465 16211 22123 59001 100042777 22195 78523 100039592 15516 109801 100040970 26446 66094 100043876 225363 66973 26440 66409 59029 12729 20815 101943 22335 103573 67781 20639 231872 12468 20103 13204 53605 268373 110052 68981 17463 99138 12462 12417 67097 100040519 11777 100042069 12330 628438 107508 18972 667739 17220 30877 66446 28126 12785 225027 18673 56200 108062 22333 51788 229279 26965 66870 26445 19934 18393 12428 105148 14852 12034 18538 20462 22194 19826 667279 19899 22384 20823 666609 27050 14719 70247 67332 671392 20383 107995 68988 110639 12465 230721 12237 20810 70769 23983 12461 50995 22327 53379 12858 27756 432502 14208 110809 230908 12544 28185 18102 17869 218236 100043508 51797 18458 15452 85305 11431 24015 18148 19384 22627 55944 13690 14694 53381 12464 13665 100039786 11792 13684 13681 BIOCARTA_NGF_PATHWAY%MSIGDB_C2%BIOCARTA_NGF_PATHWAY BIOCARTA_NGF_PATHWAY 110157 26417 15461 100039026 18708 30955 26395 26419 18053 18803 14281 18706 13712 18049 20416 16476 14784 20662 BIOCARTA_CD40_PATHWAY%MSIGDB_C2%BIOCARTA_CD40_PATHWAY BIOCARTA_CD40_PATHWAY 53859 230233 18035 22031 19697 26401 22034 12675 21929 19252 21939 18033 21947 16150 16151 HALLMARK_COAGULATION%MSIGDB_C2%HALLMARK_COAGULATION HALLMARK_COAGULATION 13034 259277 19123 20692 12263 18591 11905 227753 67603 17395 16971 15360 18791 17384 17385 17175 56213 14118 17287 56193 13036 13038 64383 11843 93691 108078 17133 13039 83995 17387 56744 14060 232345 229445 11812 18550 19072 21824 71753 13007 14693 98710 16993 14064 13482 17388 14360 76453 11806 11727 17394 21859 54368 56373 15235 14071 16424 12759 94175 19141 17195 109821 18815 12527 14268 21825 14161 99571 16784 17392 16416 23921 18787 11537 13030 14066 18792 22371 14962 317677 19128 15378 21857 14723 14058 17390 18788 14061 93732 19353 12259 667277 230558 12334 12279 58992 14069 223864 16621 69379 16952 93721 11813 13190 22388 12337 11814 12153 18441 19733 110382 12371 12628 320202 14544 56405 76467 16398 68337 14701 67898 66901 12630 17393 20196 20703 22041 12266 66383 236733 20193 15451 54381 12845 18613 11502 12258 21789 SIG_CHEMOTAXIS%MSIGDB_C2%SIG_CHEMOTAXIS SIG_CHEMOTAXIS 19211 16439 320207 83767 228026 16332 11652 21981 212541 16438 70584 18481 23797 214230 11651 241656 18479 16440 20215 228785 20102 19878 26360 26934 12632 14567 14569 18708 19877 30955 107589 224105 16885 66713 18706 18741 12631 213498 12229 228359 73178 74117 18707 171207 PID_S1P_S1P4_PATHWAY%MSIGDB_C2%PID_S1P_S1P4_PATHWAY PID_S1P_S1P4_PATHWAY 26417 14687 13611 14681 94226 11848 14679 18803 26413 14677 14674 14673 14678 HALLMARK_ANDROGEN_RESPONSE%MSIGDB_C2%HALLMARK_ANDROGEN_RESPONSE HALLMARK_ANDROGEN_RESPONSE 30960 218294 66065 117167 66384 60596 544963 627557 17289 17761 110651 73998 109785 107652 56469 69608 234515 76687 11651 231070 239273 14782 56228 432729 56847 13167 12007 74205 72155 11504 671878 20322 15446 53416 19341 16410 30051 68801 22596 12010 14375 207565 14679 83397 18813 18095 50528 12167 109711 17152 328365 56436 74754 56376 19229 100040592 12445 76267 20807 17988 20393 192657 65112 15357 229055 107094 13714 20363 16691 14595 106869 20229 54608 59007 13521 66884 319554 11732 26557 21807 17132 14229 24000 19012 333433 71817 20249 67760 71371 12571 70361 14958 27362 12443 16880 22196 ST_INTEGRIN_SIGNALING_PATHWAY%MSIGDB_C2%ST_INTEGRIN_SIGNALING_PATHWAY ST_INTEGRIN_SIGNALING_PATHWAY 232906 12928 20663 26419 11652 212541 70584 18481 23797 214230 241656 11651 22376 330662 30957 74769 228785 11350 54126 26420 26400 19877 26414 107589 14786 224105 16400 26398 18803 18706 57321 13196 109711 14360 26403 14784 73341 12927 19211 110157 109880 12389 21894 16404 16398 18479 241226 16402 14083 26413 16403 213119 319480 22793 109700 20416 16401 60597 19878 26360 104099 19099 20662 70549 18453 13844 56044 67733 51789 19418 71302 22323 110750 12578 16202 66713 234779 17532 18770 20779 74117 BIOCARTA_MEF2D_PATHWAY%MSIGDB_C2%BIOCARTA_MEF2D_PATHWAY BIOCARTA_MEF2D_PATHWAY 18750 18019 18018 19057 19055 19056 18751 640703 12334 17261 104248 433759 15182 328572 69543 12336 HALLMARK_APICAL_JUNCTION%MSIGDB_C2%HALLMARK_APICAL_JUNCTION HALLMARK_APICAL_JUNCTION 15896 12550 20563 16332 83964 13383 22325 12490 16774 65964 14677 11790 192897 17886 73341 22029 26412 78369 20970 16511 20410 192156 11465 13003 11474 21810 11472 22371 21827 108100 18188 19211 107581 12821 12153 16398 213119 22793 104099 19264 218397 18613 26416 12388 11502 20779 15894 16480 12385 13406 231070 15107 17395 20909 65970 20963 14118 16780 18710 12839 11705 18803 21872 109711 73178 19294 20392 12908 16660 67938 386463 69847 14012 75599 170761 11688 239857 18016 23794 224912 20312 13505 17242 232975 12564 18417 12561 12560 12563 94332 68810 16412 56173 12740 58998 57342 22329 23792 58235 20416 242653 56863 16782 60533 67268 14595 11464 20336 18643 22330 11475 68794 11461 14086 98053 17123 110380 170786 11652 11490 23797 20130 102657 264064 229715 269643 18383 18763 99151 60595 13822 77579 103733 23912 74769 12308 11548 16151 12805 53624 68188 17390 56191 18015 12741 21838 68481 245537 23880 54353 21843 100017 15898 14431 320840 69192 13507 19261 269116 14786 18190 16400 22784 93737 14026 60363 56492 18175 12555 54420 216856 71740 12552 18515 64540 12524 105827 54419 12798 20163 56217 244864 15461 16367 13649 14083 26415 19094 64930 22629 19354 11459 22323 17698 12331 76709 14678 BIOCARTA_CCR3_PATHWAY%MSIGDB_C2%BIOCARTA_CCR3_PATHWAY BIOCARTA_CCR3_PATHWAY 18750 26417 110157 15461 20292 18705 12771 14688 14682 237038 26395 17906 16885 329251 11848 18751 14699 14083 26413 12631 18795 19878 HALLMARK_ESTROGEN_RESPONSE_EARLY%MSIGDB_C2%HALLMARK_ESTROGEN_RESPONSE_EARLY HALLMARK_ESTROGEN_RESPONSE_EARLY 80888 13655 20856 20520 21844 11515 14200 226251 16001 12017 11835 76459 52250 20893 21987 20778 20112 225115 14609 11839 21983 14228 20439 11828 76453 17863 15205 225182 71946 20148 20525 14389 14281 16452 12700 13709 233016 21817 14137 99929 14104 107094 16691 14595 18631 13360 54608 13521 14229 22403 20347 16600 54200 26458 69540 17355 14585 19713 59020 228839 24056 16663 16665 12308 53624 53883 207596 68801 55948 64292 23972 244152 16324 12614 20315 67815 17829 328329 21420 16529 12043 77411 67689 50768 69454 21786 19329 286940 16010 94249 106572 229504 17864 20972 268527 19419 50905 18432 76025 212862 22234 20675 19401 71790 67117 21847 22248 226101 105675 11640 78914 16668 23802 100041004 15460 268860 22433 74694 20276 101490 381269 20539 16195 11854 140765 11988 18166 58208 17695 16763 98952 73710 66270 12398 193796 23989 54326 16206 319613 171180 171531 13603 22057 12311 27410 243864 12505 106957 223254 97998 17965 73296 230603 18667 56177 20602 268480 26941 142688 209497 217837 211652 27375 20501 76199 56350 71529 107586 55963 116914 432530 22393 18442 11605 224674 27360 225845 75007 99543 268903 232174 14302 56488 20510 17300 241769 17869 27205 13710 12443 69226 69169 PID_BETA_CATENIN_DEG_PATHWAY%MSIGDB_C2%PID_BETA_CATENIN_DEG_PATHWAY PID_BETA_CATENIN_DEG_PATHWAY 12387 13544 12006 243369 16974 606496 13543 93687 104318 22416 27373 11789 14367 13542 12005 26965 56637 21402 BIOCARTA_BIOPEPTIDES_PATHWAY%MSIGDB_C2%BIOCARTA_BIOPEPTIDES_PATHWAY BIOCARTA_BIOPEPTIDES_PATHWAY 18750 110157 15461 11606 26395 26396 19229 26419 385643 20848 12322 108058 12323 12325 26413 640703 16452 20846 20416 20850 20851 20662 11609 26417 14061 20849 14688 107589 20852 20847 18751 14672 14699 18803 26416 14677 14360 12568 14784 ST_ADRENERGIC%MSIGDB_C2%ST_ADRENERGIC ST_ADRENERGIC 16439 110157 228550 109880 14682 14962 14459 16438 110094 11651 13649 11835 26413 16440 320404 13138 18708 20296 26414 11886 19288 14672 16521 16524 12796 14676 18706 26416 18741 16519 14677 11789 20779 18707 PID_VEGF_VEGFR_PATHWAY%MSIGDB_C2%PID_VEGF_VEGFR_PATHWAY PID_VEGF_VEGFR_PATHWAY 18654 14254 16542 18186 22340 22341 14257 18187 14205 22339 PID_ATF2_PATHWAY%MSIGDB_C2%PID_ATF2_PATHWAY PID_ATF2_PATHWAY 21823 26419 16334 26554 12912 17390 13198 18015 26417 21808 26420 12567 11423 16478 71355 16476 12428 18750 12043 16477 13008 18986 15205 11910 19017 19645 12048 18126 11909 19252 26413 11846 14281 19094 16193 20339 15978 20174 83430 13982 81601 18595 18218 240672 63953 12702 81703 26416 12400 26914 15132 20724 12123 18792 13197 12189 328572 12443 PID_P38_ALPHA_BETA_PATHWAY%MSIGDB_C2%PID_P38_ALPHA_BETA_PATHWAY PID_P38_ALPHA_BETA_PATHWAY 64143 12143 22612 22034 18481 26406 19252 18479 19094 19091 16818 56044 26399 26404 17096 26397 224105 19353 19766 26398 18218 14191 63953 26416 15162 66513 14360 20779 70686 216527 ST_G_ALPHA_S_PATHWAY%MSIGDB_C2%ST_G_ALPHA_S_PATHWAY ST_G_ALPHA_S_PATHWAY 110157 223864 109880 19418 12913 14459 14962 11886 26413 57321 12796 12912 20779 217463 BIOCARTA_NKCELLS_PATHWAY%MSIGDB_C2%BIOCARTA_NKCELLS_PATHWAY BIOCARTA_NKCELLS_PATHWAY 26417 20963 16643 16797 18708 12010 26395 19229 22324 19353 15007 18479 18706 16412 16641 16173 15170 NABA_ECM_REGULATORS%MSIGDB_C2%NABA_ECM_REGULATORS NABA_ECM_REGULATORS 13034 11905 11489 210530 18791 11495 14789 16716 83995 18451 13011 13012 15160 20723 73720 76770 112407 58214 14071 319433 50701 20720 74468 20568 20725 116872 18816 20317 240725 68054 380780 331535 12406 67931 72043 19143 66222 71907 20248 394252 268591 20716 21817 66957 241197 16949 11501 16950 94352 67573 209378 107250 56401 109685 77042 16425 215015 80752 226243 112406 545291 78558 13032 13041 228756 19025 330723 18452 56464 15587 15586 13013 18787 13014 67868 13030 18792 71756 78240 13010 64138 208659 11487 74145 14068 15442 12401 240322 216725 223838 330119 110595 21892 21818 331046 74176 241636 13522 20713 208936 271127 235505 215095 13706 69066 30806 109901 108154 240913 224697 108153 279028 239337 235130 237360 14058 26433 19142 18822 26432 58223 23948 22072 17389 320452 74443 241196 71869 18552 18553 210622 23850 24087 18491 270086 66627 21858 640543 19146 17288 26561 17391 30800 214766 20719 234911 118453 240047 58992 385643 12153 17393 20703 11488 11496 11492 13524 58860 16948 11500 71078 244486 110751 13033 353188 11699 66548 229595 269959 77794 77739 20724 11502 12258 56622 16426 17386 17395 11504 21816 217847 17384 17385 17175 56213 17287 13036 13038 13039 17387 232345 14060 229445 17388 17394 21859 23794 16424 94175 16427 18815 23792 13035 17381 17392 59007 13040 11490 11491 21857 17390 18788 14061 11606 PID_IFNG_PATHWAY%MSIGDB_C2%PID_IFNG_PATHWAY PID_IFNG_PATHWAY 59004 15979 12362 16451 26401 26395 56469 12703 11651 20848 12322 108058 12323 12608 19247 12325 16391 26413 96979 16452 56717 20846 69635 19255 18753 16176 16362 26417 15978 18708 17131 18706 12929 12914 107746 109905 12402 26403 215449 328572 BIOCARTA_D4GDI_PATHWAY%MSIGDB_C2%BIOCARTA_D4GDI_PATHWAY BIOCARTA_D4GDI_PATHWAY 11545 12362 11783 11857 14939 18646 670717 12370 12367 16476 11855 12371 PID_EPHB_FWD_PATHWAY%MSIGDB_C2%PID_EPHB_FWD_PATHWAY PID_EPHB_FWD_PATHWAY 15461 12928 13845 104015 26395 26921 20130 18479 26413 14083 545156 16443 14799 13643 20416 22041 18176 26417 13844 218397 270190 13642 18708 13641 19877 17973 14786 19353 13429 16653 18706 19303 109905 13846 73178 20779 13640 215449 14784 PID_IL2_PI3K_PATHWAY%MSIGDB_C2%PID_IL2_PI3K_PATHWAY PID_IL2_PI3K_PATHWAY 21752 16184 12043 16183 17863 16451 19697 16453 22234 15519 12048 56484 11651 14389 19247 208449 56717 18033 20416 20662 16818 13555 18708 18762 16186 16185 19353 667739 20597 18706 13669 17869 14784 PID_INSULIN_GLUCOSE_PATHWAY%MSIGDB_C2%PID_INSULIN_GLUCOSE_PATHWAY PID_INSULIN_GLUCOSE_PATHWAY 20528 100039786 19047 11652 22628 50518 22631 11651 54401 140491 210789 22318 16334 240028 14936 16337 22629 20909 22627 55948 18762 104215 18759 106628 20913 56637 PID_CASPASE_PATHWAY%MSIGDB_C2%PID_CASPASE_PATHWAY PID_CASPASE_PATHWAY 22030 57913 11820 14453 66593 12370 20874 22352 20230 71609 227753 12905 21418 20740 12369 101706 12632 670717 20787 16885 21937 19766 13368 13347 12368 12043 11797 12122 12362 11545 12028 14939 18646 26401 16906 12367 228355 16668 12371 21969 14083 11459 11798 16905 12366 21926 11783 12363 11857 16907 11796 HALLMARK_ADIPOGENESIS%MSIGDB_C2%HALLMARK_ADIPOGENESIS HALLMARK_ADIPOGENESIS 66588 68202 16651 56428 80888 268301 26379 67809 12039 170439 26457 16443 19285 12819 11836 94044 13476 72039 20778 69721 13358 110826 22117 21351 27376 66152 11637 107589 13350 22245 17713 110391 12826 103172 20324 12476 29864 223775 246747 19016 77037 18407 20887 17436 11512 12491 104112 330064 232089 67767 11933 67171 13830 57264 18641 11757 11520 170768 66445 70316 225028 16956 14778 625249 209378 11674 13360 22228 57875 18107 66375 67442 11430 18984 12580 11429 66878 13602 20514 56085 16404 16775 12266 26926 66447 74185 11669 12452 13202 11816 18618 13197 14085 66052 72157 17448 11303 14571 27047 13382 12675 15107 227095 56451 15929 16890 52538 68465 11363 93747 12896 12683 23945 11409 67460 70335 17001 11450 12908 20280 15926 22340 13850 20411 11600 20850 12359 16922 51798 667310 56273 27362 16880 18569 19376 22272 22190 432676 15979 13171 624814 20509 74610 217430 12861 66916 18606 102693 22628 108954 67914 20618 11804 69956 69574 108958 16846 66142 68750 12868 216820 14792 102247 56298 66205 67247 22057 59010 68653 19218 23881 21881 11861 20168 19043 13120 235339 76614 230027 66148 109019 67680 50907 67834 66092 23943 52064 28169 116848 22273 14732 21353 268566 12974 14366 12053 11770 100040287 11364 BIOCARTA_STATHMIN_PATHWAY%MSIGDB_C2%BIOCARTA_STATHMIN_PATHWAY BIOCARTA_STATHMIN_PATHWAY 19088 19084 19087 19085 12481 18749 12322 108058 12323 12534 12325 26415 12326 12500 12501 12502 12503 PID_HNF3A_PATHWAY%MSIGDB_C2%PID_HNF3A_PATHWAY PID_HNF3A_PATHWAY 320951 20387 15375 15377 15376 18986 78330 114604 100041004 22433 16334 12608 11835 13508 14281 22370 20423 22287 20703 11957 11764 72082 17979 20390 13982 20683 12822 667310 18095 268903 12914 12576 12189 238055 16476 18029 328572 11819 14526 18027 BIOCARTA_PDGF_PATHWAY%MSIGDB_C2%BIOCARTA_PDGF_PATHWAY BIOCARTA_PDGF_PATHWAY 18750 110157 15461 100039026 16451 26395 26401 26419 20807 20848 14281 13712 20846 20416 20850 20851 20662 26417 218397 18708 20849 30955 20852 20847 26398 18595 18751 18803 18590 18706 16476 14784 HALLMARK_UNFOLDED_PROTEIN_RESPONSE%MSIGDB_C2%HALLMARK_UNFOLDED_PROTEIN_RESPONSE HALLMARK_UNFOLDED_PROTEIN_RESPONSE 20856 76687 13682 20293 100037258 14828 11911 231997 11910 192170 68090 52639 50783 381801 27053 72599 69065 67134 52530 16006 27966 20416 73192 66482 105785 27362 13666 112419 18148 22151 18044 23825 18045 66583 276919 17768 22642 75901 11972 28146 67398 78943 12317 13191 107513 69162 70640 71853 74322 53621 22027 192193 234699 75416 12282 64209 74108 20818 52808 50911 227715 54124 27998 109075 218693 50912 233908 218343 58233 69019 208643 102462 72198 107272 69048 20044 56494 104625 29810 72068 15270 66161 12611 56529 15526 56454 110960 77591 74747 226641 228998 231452 105148 67207 13665 22339 22631 13684 22433 13681 20539 12608 13629 13685 245474 50527 109019 50907 55963 22393 70769 16573 BIOCARTA_TH1TH2_PATHWAY%MSIGDB_C2%BIOCARTA_TH1TH2_PATHWAY BIOCARTA_TH1TH2_PATHWAY 16162 15978 16184 16161 12487 16183 15979 14968 16182 14969 16190 15980 21939 12524 21947 16160 16173 16159 16189 PID_HIF2PATHWAY%MSIGDB_C2%PID_HIF2PATHWAY PID_HIF2PATHWAY 13819 18999 67923 18174 14254 319594 16542 22346 16341 11540 112407 14297 22339 20525 11792 13712 20893 23871 11863 22160 17387 112406 20683 93759 12914 18787 13636 17684 328572 18655 13856 26357 PID_ARF6_TRAFFICKING_PATHWAY%MSIGDB_C2%PID_ARF6_TRAFFICKING_PATHWAY PID_ARF6_TRAFFICKING_PATHWAY 18806 30948 12387 13430 20528 12550 18805 18717 16334 13618 30957 11845 16410 16400 67300 16184 11555 107371 69940 105504 11607 211914 16404 16398 16402 241226 16403 16412 213119 216859 16593 12000 319480 12876 109700 24044 16401 104099 22095 22319 70834 56044 66482 20336 53413 211446 12388 18102 12385 HALLMARK_WNT_BETA_CATENIN_SIGNALING%MSIGDB_C2%HALLMARK_WNT_BETA_CATENIN_SIGNALING HALLMARK_WNT_BETA_CATENIN_SIGNALING 12387 12006 14534 16450 11491 18132 27401 19664 59287 19206 13388 93960 19165 18128 14370 18222 27373 12444 15184 19015 13380 20602 15214 15213 234130 14296 21414 103806 13543 16842 22408 14677 12005 22059 14362 22420 232232 26965 15182 16449 17869 22419 PID_NFAT_3PATHWAY%MSIGDB_C2%PID_NFAT_3PATHWAY PID_NFAT_3PATHWAY 100039026 227720 16211 19384 26419 100039592 93687 12326 104248 103573 18753 14225 26417 18712 22627 26410 26420 18762 55948 12015 56637 18750 12043 56398 100039786 12028 19058 53901 26401 238276 54720 12048 22628 12367 22631 54401 18747 17261 14232 22629 18019 18018 15370 19055 19056 18021 18751 26416 12914 18754 18752 18761 328572 18755 BIOCARTA_ETC_PATHWAY%MSIGDB_C2%BIOCARTA_ETC_PATHWAY BIOCARTA_ETC_PATHWAY 66052 66925 66945 22273 11739 14571 17708 54405 670717 11740 67680 11946 ST_INTERFERON_GAMMA_PATHWAY%MSIGDB_C2%ST_INTERFERON_GAMMA_PATHWAY ST_INTERFERON_GAMMA_PATHWAY 15978 15979 19273 19692 16451 16452 20846 12700 58523 PID_ARF6_PATHWAY%MSIGDB_C2%PID_ARF6_PATHWAY PID_ARF6_PATHWAY 19159 13645 11555 14682 11607 13649 216859 15234 11845 22095 212285 70676 231821 16867 16554 109689 50753 320495 232227 17973 78618 216869 16416 16399 14675 14672 14676 17295 19303 13636 20779 216963 19158 13836 BIOCARTA_RAB_PATHWAY%MSIGDB_C2%BIOCARTA_RAB_PATHWAY BIOCARTA_RAB_PATHWAY 17274 11891 19346 11459 19324 56382 59021 19341 53869 19349 19339 271457 SA_REG_CASCADE_OF_CYCLIN_EXPR%MSIGDB_C2%SA_REG_CASCADE_OF_CYCLIN_EXPR SA_REG_CASCADE_OF_CYCLIN_EXPR 13555 12447 12566 12567 12427 12578 104394 12448 12576 667929 12443 242705 12428 BIOCARTA_NFAT_PATHWAY%MSIGDB_C2%BIOCARTA_NFAT_PATHWAY BIOCARTA_NFAT_PATHWAY 110157 15461 11606 13019 26395 15200 26419 17260 11651 16000 18749 93687 12317 640703 26413 215303 12326 52163 13614 14225 26417 14173 14463 18019 18018 14061 73181 18708 19057 11459 30955 19088 19055 19084 19087 19056 19085 16878 18021 18091 18706 26416 12914 56637 15110 230899 17882 15111 BIOCARTA_IL2RB_PATHWAY%MSIGDB_C2%BIOCARTA_IL2RB_PATHWAY BIOCARTA_IL2RB_PATHWAY 16184 110157 14103 15461 12043 16367 16451 16453 12703 12048 12633 11651 64685 26413 14281 14102 20416 20850 20851 20662 26417 268373 20963 13555 18708 30955 16186 12015 16185 22780 18706 12702 12929 12402 17869 15170 14784 BIOCARTA_GH_PATHWAY%MSIGDB_C2%BIOCARTA_GH_PATHWAY BIOCARTA_GH_PATHWAY 18750 110157 15461 20111 20528 16367 26395 12703 20807 16334 26413 16337 16452 20416 20850 20851 20662 26417 21405 18708 30955 18751 18803 18706 15170 14784 14600 PID_INTEGRIN_A4B1_PATHWAY%MSIGDB_C2%PID_INTEGRIN_A4B1_PATHWAY PID_INTEGRIN_A4B1_PATHWAY 12928 21894 19229 11308 19262 17242 22631 13522 18749 18747 14083 16412 14268 330662 22329 11845 21825 16401 20750 12475 19084 19353 19085 21826 140559 270152 12520 67374 19303 20779 216963 12927 17882 PID_SYNDECAN_2_PATHWAY%MSIGDB_C2%PID_SYNDECAN_2_PATHWAY PID_SYNDECAN_2_PATHWAY 57916 15461 12028 21803 16772 26419 385643 12367 16398 18747 16402 26413 16412 14268 53378 12981 18753 17390 26417 18015 13844 218397 22350 14694 16774 11848 15529 60409 12390 12361 269587 20779 PID_IL8_CXCR1_PATHWAY%MSIGDB_C2%PID_IL8_CXCR1_PATHWAY PID_IL8_CXCR1_PATHWAY 18750 110355 18805 227288 11651 18607 104709 14702 17096 109689 14688 30955 216869 271457 14675 13429 18751 14191 14676 18797 15162 18796 12402 18754 18752 18795 14678 NABA_COLLAGENS%MSIGDB_C2%NABA_COLLAGENS NABA_COLLAGENS 107581 329941 12837 12840 12821 12841 12825 12842 12817 12813 12814 12834 12835 12819 12832 12815 12833 12818 12829 12839 12828 77018 94216 12824 140709 12830 12823 12826 12836 12816 12827 237759 245026 53867 213945 12822 373864 12831 69700 73368 71355 12843 BIOCARTA_MONOCYTE_PATHWAY%MSIGDB_C2%BIOCARTA_MONOCYTE_PATHWAY BIOCARTA_MONOCYTE_PATHWAY 16408 20339 16409 20343 16414 16412 18613 16401 20344 15894 12505 PID_IL27_PATHWAY%MSIGDB_C2%PID_IL27_PATHWAY PID_IL27_PATHWAY 16183 50931 21803 16451 16171 57765 246779 20848 16195 16452 20846 16160 20850 16173 16159 54721 16162 16193 15978 16176 16161 50498 20849 20847 21926 14462 PID_EPHA_FWDPATHWAY%MSIGDB_C2%PID_EPHA_FWDPATHWAY PID_EPHA_FWDPATHWAY 320207 12928 53972 12143 13837 13838 22612 13841 13835 13842 13840 13637 57257 22325 16818 104709 442801 17096 19877 30955 11848 13839 14191 18803 13638 12929 15162 12402 14360 12568 13636 20779 13640 13836 BIOCARTA_IGF1R_PATHWAY%MSIGDB_C2%BIOCARTA_IGF1R_PATHWAY BIOCARTA_IGF1R_PATHWAY 26417 110157 15461 20111 16367 18708 19088 26395 12015 19084 19087 19085 432530 11651 18749 16001 26413 18706 20416 22629 14784 20662 BIOCARTA_INTRINSIC_PATHWAY%MSIGDB_C2%BIOCARTA_INTRINSIC_PATHWAY BIOCARTA_INTRINSIC_PATHWAY 110135 58992 14069 14062 16621 14161 19123 14067 99571 14061 12829 14071 12828 94216 11905 12830 385643 12826 12827 109821 19128 12258 14058 PID_AURORA_A_PATHWAY%MSIGDB_C2%PID_AURORA_A_PATHWAY PID_AURORA_A_PATHWAY 56371 218977 12877 66077 18035 18245 320165 75786 19384 20877 72119 11651 20878 18479 18747 12615 21335 16475 21770 54126 218397 11799 83431 12531 100121 17246 22059 56637 13197 12189 216963 PID_A6B1_A6B4_INTEGRIN_PATHWAY%MSIGDB_C2%PID_A6B1_A6B4_INTEGRIN_PATHWAY PID_A6B1_A6B4_INTEGRIN_PATHWAY 18750 13645 15461 16773 100039786 226519 15235 12550 20183 16772 12821 13867 22628 22631 54401 11651 13649 12369 16412 16403 12527 16775 20416 23928 19882 22629 16782 13866 18858 20182 16779 16777 22627 16780 18708 16776 16774 55948 19353 18706 192897 16175 17295 20181 14784 PID_SMAD2_3NUCLEAR_PATHWAY%MSIGDB_C2%PID_SMAD2_3NUCLEAR_PATHWAY PID_SMAD2_3NUCLEAR_PATHWAY 59004 226519 16153 17127 228839 21815 22642 75901 11651 13016 11835 14106 12705 94112 15378 12912 13390 15228 12399 76793 16419 56458 21781 17187 19650 22337 12567 20482 15481 14836 60406 104394 20687 54601 16476 54123 13559 19646 20466 11910 229615 12566 20481 17260 56484 14534 11909 12608 15977 14281 17927 18519 433759 17128 16191 12393 12579 17978 17977 20185 209446 100041953 13982 20467 18091 14815 17131 20683 17126 14462 12400 12914 21423 18787 12575 15182 17869 328572 12843 245688 HALLMARK_ESTROGEN_RESPONSE_LATE%MSIGDB_C2%HALLMARK_ESTROGEN_RESPONSE_LATE HALLMARK_ESTROGEN_RESPONSE_LATE 80888 16795 12550 21844 12017 74335 76459 21987 57444 20778 110826 22117 20112 21924 12709 23834 14228 21983 20439 20873 20460 272551 17863 22695 225182 12349 16592 19143 12527 268591 233016 20716 14137 15902 13360 22403 20347 16600 26458 21823 21973 68801 67880 22235 93732 64292 23972 21420 21786 16010 286940 12389 106572 71790 226101 15460 100041004 22433 20539 20703 13603 27410 12311 17965 18667 26941 20602 107995 12228 381290 235611 68947 17002 56335 20446 268903 12443 21789 13655 16451 20520 56096 12427 14419 56538 17937 13537 20322 15360 74246 19116 217325 76854 11898 56460 66109 30045 23795 13731 71228 14620 114663 54135 56808 18546 11671 54189 71982 56183 11839 69724 100041785 17434 56017 22249 18415 631304 76453 17229 13418 53314 209268 22122 17294 15452 17242 20202 14281 16452 12876 12700 16782 14184 269951 54608 13521 63959 26557 57266 14229 54200 19348 69540 17355 19713 59020 16663 53883 18569 55948 64058 20315 16529 67689 12043 69454 94249 50905 212862 20675 67117 105675 23802 20276 140765 16195 18166 26415 98952 20393 22057 243864 223254 12505 19218 56177 268480 17172 217837 27375 20501 19088 56350 107586 55963 22393 11605 27360 225845 232174 14302 56488 17300 15170 BIOCARTA_GSK3_PATHWAY%MSIGDB_C2%BIOCARTA_GSK3_PATHWAY BIOCARTA_GSK3_PATHWAY 12387 19697 11651 18607 18033 16803 19106 19052 18708 12475 14609 17874 21898 16842 22408 18706 14677 11789 13542 12005 14362 56637 16179 17087 117149 12443 54473 BIOCARTA_AKAP13_PATHWAY%MSIGDB_C2%BIOCARTA_AKAP13_PATHWAY BIOCARTA_AKAP13_PATHWAY 18749 11848 53978 75547 14674 19088 65086 14673 14745 19087 19082 BIOCARTA_CFTR_PATHWAY%MSIGDB_C2%BIOCARTA_CFTR_PATHWAY BIOCARTA_CFTR_PATHWAY 18749 26941 11555 22350 12638 19088 19084 19087 19085 432530 BIOCARTA_EDG1_PATHWAY%MSIGDB_C2%BIOCARTA_EDG1_PATHWAY BIOCARTA_EDG1_PATHWAY 18750 20698 13609 11651 20598 14083 26413 16410 26417 18708 77629 14688 30955 19353 16416 432530 11848 11886 18595 18751 20597 14699 18590 18706 14677 18795 20779 PID_BCR_5PATHWAY%MSIGDB_C2%PID_BCR_5PATHWAY PID_BCR_5PATHWAY 18035 100039026 18036 26411 19697 26419 240354 22034 12675 24056 11651 12325 18033 14130 16151 22325 23871 26417 20963 18708 18987 19353 18706 12518 16150 15985 16476 14784 19211 110157 15461 94212 26401 26395 26409 18607 16331 26413 14281 13712 20416 12988 20662 19264 26377 108723 108837 18018 12047 218397 12517 83490 17096 19057 17060 19055 19056 12478 13448 12483 26416 234779 12229 12042 15170 PID_CD40_PATHWAY%MSIGDB_C2%PID_CD40_PATHWAY PID_CD40_PATHWAY 53859 11797 18035 22029 22031 22030 19697 26401 16453 26419 22034 12048 11651 21929 19094 21939 18033 21947 20850 56196 26420 26414 208650 64435 26398 26416 11796 17869 16476 16189 BIOCARTA_FIBRINOLYSIS_PATHWAY%MSIGDB_C2%BIOCARTA_FIBRINOLYSIS_PATHWAY BIOCARTA_FIBRINOLYSIS_PATHWAY 110135 74145 14062 14161 18815 18788 99571 14061 18787 18792 18791 56373 HALLMARK_INTERFERON_GAMMA_RESPONSE%MSIGDB_C2%HALLMARK_INTERFERON_GAMMA_RESPONSE HALLMARK_INTERFERON_GAMMA_RESPONSE 16651 16149 16168 15976 16421 57444 19106 98999 50523 22038 19225 21929 16193 14969 56421 16154 12575 15251 19166 12183 12370 22035 17750 78388 18854 21930 20847 230073 19766 18578 12515 59027 26445 319974 107607 109552 70082 16068 53620 24105 71805 192786 14528 140795 18950 14938 27056 12703 20454 14747 15006 75345 58203 12628 66892 27007 246727 110168 16391 242248 30934 22320 56045 15930 71939 22271 71664 246728 72925 14129 21928 12226 12265 17979 67245 16190 672511 66552 236573 209588 19171 16963 20344 12258 15894 15061 58185 14190 15945 16362 18712 20293 15900 16196 12010 56066 20306 192656 16185 17874 15007 80876 67775 20821 17069 12362 66307 209086 67138 231655 71586 100038882 109032 56338 667370 19246 70110 99899 64685 20848 547253 52668 22169 72075 12984 14102 16452 20846 22329 20304 60533 246696 231712 74481 74157 80861 74735 14293 71701 243771 22670 268749 19188 66988 15958 108670 217069 19039 16912 100121 66141 16913 56417 71371 234311 69550 20656 229003 24110 112419 18035 22375 14962 17768 19167 317677 55932 65972 16363 12369 18033 16364 18783 16822 21354 667277 12524 54123 17329 21356 14998 20452 14991 14960 16169 12367 19186 12494 21939 19255 11861 20849 56791 12363 12702 15170 PID_TAP63_PATHWAY%MSIGDB_C2%PID_TAP63_PATHWAY PID_TAP63_PATHWAY 21420 100039786 12028 17304 13654 18817 243369 20148 12675 23886 20423 73389 14102 16396 11486 107568 18753 11350 18104 18854 22337 16400 64058 14252 12578 20683 14027 192119 14149 16009 18294 22061 22032 192897 17246 66993 63955 20724 12575 20833 14776 13197 16150 73472 16449 328572 68048 229933 PID_DNA_PK_PATHWAY%MSIGDB_C2%PID_DNA_PK_PATHWAY PID_DNA_PK_PATHWAY 56626 66408 13000 72103 319583 54125 100039026 75570 59047 22596 14375 21673 19090 13001 108138 227525 BIOCARTA_TNFR2_PATHWAY%MSIGDB_C2%BIOCARTA_TNFR2_PATHWAY BIOCARTA_TNFR2_PATHWAY 53859 21938 230233 18035 22029 22031 22030 19697 26401 12675 16992 21929 19766 19252 21353 18033 16150 16151 BIOCARTA_TFF_PATHWAY%MSIGDB_C2%BIOCARTA_TFF_PATHWAY BIOCARTA_TFF_PATHWAY 26417 15461 12387 18708 30955 670717 12015 12371 11651 11848 13649 14083 11783 26413 18706 16412 20416 14784 14600 20662 BIOCARTA_IL22BP_PATHWAY%MSIGDB_C2%BIOCARTA_IL22BP_PATHWAY BIOCARTA_IL22BP_PATHWAY 237310 20849 16451 16453 20852 230828 20847 20848 16154 12702 16452 20846 116849 20850 20851 54721 BIOCARTA_CSK_PATHWAY%MSIGDB_C2%BIOCARTA_CSK_PATHWAY BIOCARTA_CSK_PATHWAY 16818 22637 14968 14969 14688 12504 19088 19084 19087 19085 432530 18749 14699 12914 12500 12501 12502 12503 12988 19264 PID_IL5_PATHWAY%MSIGDB_C2%PID_IL5_PATHWAY PID_IL5_PATHWAY 16192 18712 16191 17096 18708 19247 18706 12984 53378 16452 12700 20850 14784 20851 PID_P38_MK2_PATHWAY%MSIGDB_C2%PID_P38_MK2_PATHWAY PID_P38_MK2_PATHWAY 110157 100039786 22627 16985 21823 22084 14009 15507 55948 22628 22631 54401 17164 20807 102626 26416 12531 21423 19094 12912 22629 BIOCARTA_TOLL_PATHWAY%MSIGDB_C2%BIOCARTA_TOLL_PATHWAY BIOCARTA_TOLL_PATHWAY 53859 18035 26401 19697 26419 22034 12675 26409 14281 13712 18033 16151 19106 26399 170743 12475 26397 24088 21946 26940 81897 17874 142980 21898 26398 21899 26416 66513 68652 16150 16179 17087 16476 19013 117149 54473 HALLMARK_INFLAMMATORY_RESPONSE%MSIGDB_C2%HALLMARK_INFLAMMATORY_RESPONSE HALLMARK_INFLAMMATORY_RESPONSE 18174 11308 16153 16168 16992 19106 21938 18387 11541 16878 21983 11535 14734 67972 78369 23849 16193 109815 16176 321019 23796 13732 320910 218215 23845 16197 16561 20354 108960 12775 18793 13733 12061 16154 15465 54598 12267 19204 56212 18787 14767 14066 18439 12575 233079 50501 56696 19217 16835 54393 104443 15251 11622 27218 19734 21948 15117 16491 16518 20266 24115 380713 21336 20511 80901 73379 12506 22035 18438 269346 17986 235574 54216 64008 20288 21338 12273 54403 72413 20529 14726 74442 20530 19886 20311 17167 11987 21930 19219 18578 12515 59027 13058 326623 50778 109552 320207 14528 19419 14747 11988 15975 15451 19222 16818 20339 12521 16190 20343 12985 16175 16323 14745 17869 15894 22353 11303 19697 20698 54371 18413 15945 16362 50498 20293 12977 16174 17287 56066 20306 16177 12475 108078 24088 192656 12227 17387 16185 14679 17295 67775 17069 54199 15200 20312 64685 16402 20295 11938 13874 20304 20297 14293 16416 20299 56221 69550 18035 257632 19164 239739 21857 21897 18033 13614 16822 19267 14723 142980 54483 21942 50723 26362 56436 54123 17119 216799 17329 110157 192187 21356 15980 16169 11480 14367 21939 18414 16160 16173 11479 12986 17096 16182 18442 14676 ST_IL_13_PATHWAY%MSIGDB_C2%ST_IL_13_PATHWAY ST_IL_13_PATHWAY 16451 16190 16165 16452 16163 16164 54721 PID_CD8_TCR_DOWNSTREAM_PATHWAY%MSIGDB_C2%PID_CD8_TCR_DOWNSTREAM_PATHWAY PID_CD8_TCR_DOWNSTREAM_PATHWAY 230398 26419 15976 14283 26417 12526 26420 13813 12010 12525 16185 15007 21942 16476 18750 16184 110157 14103 15461 16183 16477 109880 14939 19058 18646 26395 26396 26413 14281 15975 13712 12500 12501 12502 12503 18176 15978 18019 18018 320139 21936 22163 20849 13656 13653 16186 19055 19056 18021 18751 16653 21926 18754 18761 BIOCARTA_IL1R_PATHWAY%MSIGDB_C2%BIOCARTA_IL1R_PATHWAY BIOCARTA_IL1R_PATHWAY 53859 18035 21803 230398 26401 19697 26419 22034 12675 26409 15977 16181 18033 16193 16176 73914 21808 26399 16180 21809 16177 26397 26940 17874 108960 21926 26416 16175 66513 16150 16179 16476 54473 BIOCARTA_CCR5_PATHWAY%MSIGDB_C2%BIOCARTA_CCR5_PATHWAY BIOCARTA_CCR5_PATHWAY 18750 20293 20303 14682 19229 26419 18751 12774 18803 640703 14281 26416 12767 16476 20315 BIOCARTA_CDK5_PATHWAY%MSIGDB_C2%BIOCARTA_CDK5_PATHWAY BIOCARTA_CDK5_PATHWAY 26417 110157 15461 26413 26395 12568 26396 13653 18049 18053 12569 BIOCARTA_LAIR_PATHWAY%MSIGDB_C2%BIOCARTA_LAIR_PATHWAY BIOCARTA_LAIR_PATHWAY 16193 20345 385643 109828 12274 15139 16408 21926 16414 16412 16175 22329 20344 16401 12266 15894 PID_RAS_PATHWAY%MSIGDB_C2%PID_RAS_PATHWAY PID_RAS_PATHWAY 18750 15461 20663 19419 20130 12323 114713 69601 74055 56715 225870 18176 240057 20662 54153 240168 19395 18015 233046 218397 19417 19418 19415 18762 16852 18751 16653 16854 18754 14784 PID_HEDGEHOG_2PATHWAY%MSIGDB_C2%PID_HEDGEHOG_2PATHWAY PID_HEDGEHOG_2PATHWAY 21808 110355 18708 14633 216869 11651 57810 319757 226861 19206 13363 19207 16147 15245 14451 117606 18706 20423 20460 19227 16976 14725 PID_VEGFR1_PATHWAY%MSIGDB_C2%PID_VEGFR1_PATHWAY PID_VEGFR1_PATHWAY 18750 15251 18127 14254 22340 12389 22339 15519 11651 18654 18607 19247 26413 18747 26417 18186 218397 18187 18708 17973 12488 216148 18751 18803 18706 12402 BIOCARTA_GABA_PATHWAY%MSIGDB_C2%BIOCARTA_GABA_PATHWAY BIOCARTA_GABA_PATHWAY 13429 56486 14395 268566 110886 14397 20779 14394 14399 14396 PID_ERBB1_INTERNALIZATION_PATHWAY%MSIGDB_C2%PID_ERBB1_INTERNALIZATION_PATHWAY PID_ERBB1_INTERNALIZATION_PATHWAY 13645 22088 24064 110157 84092 15461 13858 100041766 70527 58194 104015 13854 218038 66105 66700 231125 13649 14083 16443 15239 216080 16206 74769 20416 18176 20662 20404 54126 18708 18710 18709 208650 271457 13429 16653 18706 12402 20779 14784 18707 PID_IL3_PATHWAY%MSIGDB_C2%PID_IL3_PATHWAY PID_IL3_PATHWAY 12048 22628 22631 18749 16331 12608 14389 19247 18747 16188 12984 16452 20416 433759 12700 20850 20851 18413 18712 18708 18706 15901 194231 27058 14784 BIOCARTA_TCRA_PATHWAY%MSIGDB_C2%BIOCARTA_TCRA_PATHWAY BIOCARTA_TCRA_PATHWAY 16818 22637 14968 14969 12500 12501 12504 14360 12502 12503 19264 BIOCARTA_VITCB_PATHWAY%MSIGDB_C2%BIOCARTA_VITCB_PATHWAY BIOCARTA_VITCB_PATHWAY 18453 54338 12829 12828 20527 94216 12830 20522 12826 20525 12827 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES%MSIGDB_C2%SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES 11475 68794 14086 192176 83767 212541 70584 18481 214230 241656 11651 18479 228785 20102 26360 19878 12632 14567 14569 19877 107589 22323 224105 16885 66713 12631 18643 18645 11465 238021 73178 74117 56223 17882 PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY%MSIGDB_C2%PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY 13000 100039026 19225 19017 17260 18126 17258 17164 13684 17346 11909 102626 12608 100040260 56613 17342 73389 13685 12912 19094 13001 18783 14567 17165 13198 13714 15507 16691 271457 20544 13982 73086 26416 22059 226641 16476 22278 BIOCARTA_AKAP95_PATHWAY%MSIGDB_C2%BIOCARTA_AKAP95_PATHWAY BIOCARTA_AKAP95_PATHWAY 19052 18749 12534 68298 19088 19045 13207 19087 56399 19082 PID_ILK_PATHWAY%MSIGDB_C2%PID_ILK_PATHWAY PID_ILK_PATHWAY 12387 11545 78757 75786 29875 15519 11651 20878 21961 21335 12912 57342 103573 22793 67268 54126 20174 17931 225341 140579 64099 20613 18938 19353 76142 16202 12539 67444 17974 26431 68458 21417 56505 170736 56212 109711 19303 56637 16476 12443 13367 73341 PID_SYNDECAN_1_PATHWAY%MSIGDB_C2%PID_SYNDECAN_1_PATHWAY PID_SYNDECAN_1_PATHWAY 107581 329941 15442 12837 21803 12840 12821 12841 12825 12842 12817 12813 18747 26413 17395 53378 12834 12814 17393 15234 12215 12835 12819 20304 12832 12815 26417 12833 16776 12818 12829 12839 12828 94216 12824 12830 83995 20969 12836 12826 12816 19035 12831 12361 17295 12843 BIOCARTA_ARAP_PATHWAY%MSIGDB_C2%BIOCARTA_ARAP_PATHWAY BIOCARTA_ARAP_PATHWAY 19157 19159 99371 107338 66913 66251 72318 211673 211914 14756 74325 11840 68137 12847 105785 228998 19158 HALLMARK_IL2_STAT5_SIGNALING%MSIGDB_C2%HALLMARK_IL2_STAT5_SIGNALING HALLMARK_IL2_STAT5_SIGNALING 114716 107702 16407 109332 17760 54139 244962 19122 74734 229521 69863 18619 17082 21844 18605 18810 11905 16153 13808 66616 16163 212531 54637 54195 14299 17164 18612 12477 54167 16001 217057 11596 66395 319625 20443 320204 21943 22781 68151 20893 225010 80859 22779 20430 21938 12522 68770 26410 21664 17133 23834 16878 18030 18451 15985 12577 13011 22038 17913 22029 11520 12447 12445 12349 19883 15277 11658 14460 16188 20973 23849 17988 12444 21817 625249 21936 209378 59026 22163 15258 21941 16154 12520 20527 19217 64138 11622 18263 19734 14256 14873 269378 12506 22035 18438 18671 170743 20719 17829 20514 11852 18950 12703 17873 13601 22433 80914 16403 16206 20193 11492 17979 16190 57436 12810 20343 20344 17869 14085 18755 17117 14190 16410 15945 18712 12833 12977 15900 13813 16185 18550 14064 53314 20148 12981 12700 20750 19012 66141 12156 12168 12332 55932 19206 16364 14744 18186 52187 21942 12524 381319 17119 16184 12043 15979 19347 16004 18986 13730 16994 16178 12048 12367 94185 12505 69305 57319 12773 11861 100604 19228 12335 213056 16182 68043 216197 20274 214547 68079 381738 384009 74318 14608 67547 11641 23959 29809 20947 24066 72729 65960 110109 22247 56361 13340 71602 216233 11803 11746 BIOCARTA_IL2_PATHWAY%MSIGDB_C2%BIOCARTA_IL2_PATHWAY BIOCARTA_IL2_PATHWAY 16818 26417 110157 16184 15461 20963 16183 100039026 16451 26395 16453 26419 16186 16185 14281 13712 20416 20850 16476 20851 14784 20662 SA_PROGRAMMED_CELL_DEATH%MSIGDB_C2%SA_PROGRAMMED_CELL_DEATH SA_PROGRAMMED_CELL_DEATH 12043 12122 12125 11783 104158 12028 26885 12015 12018 12048 12042 12371 HALLMARK_SPERMATOGENESIS%MSIGDB_C2%HALLMARK_SPERMATOGENESIS HALLMARK_SPERMATOGENESIS 13000 13176 17761 21954 14447 106344 12427 83553 18125 72350 20496 12326 53422 11495 83964 27214 11421 19356 56485 21351 56324 72391 18415 11546 16833 14056 13012 18016 235559 14415 21888 14245 16165 15463 93759 20744 11516 12794 14823 18952 23980 20394 12672 13404 17773 73804 215387 15512 107970 21959 15925 30052 74438 23885 11536 22099 20878 74451 12235 18168 15563 22335 24084 17349 22024 14866 20480 11451 14840 69310 12467 11643 18598 22115 20255 18005 21958 53604 71854 30959 11471 15126 12442 21463 19119 12534 53814 56522 18285 17288 71838 97243 54137 380684 18976 50796 12686 15407 27399 17344 56088 14581 11687 109880 18551 12812 15482 68172 75553 21830 22147 56691 231600 20616 109979 17354 12745 21821 53885 68961 67946 18663 56717 56734 21744 20957 13206 20834 17776 16162 11861 214547 19087 22137 12638 PID_LYMPH_ANGIOGENESIS_PATHWAY%MSIGDB_C2%PID_LYMPH_ANGIOGENESIS_PATHWAY PID_LYMPH_ANGIOGENESIS_PATHWAY 20111 12928 14257 11651 12842 16398 16402 26413 16412 14268 19094 12912 109700 20416 16401 20662 26417 22341 14205 18708 26398 18706 26416 12843 14784 BIOCARTA_GPCR_PATHWAY%MSIGDB_C2%BIOCARTA_GPCR_PATHWAY BIOCARTA_GPCR_PATHWAY 18750 110157 15461 14682 110651 26395 18749 640703 14281 13712 12912 26417 18019 18018 73181 14688 19057 19088 19084 19055 19056 19087 19085 432530 18021 18751 14699 18803 14677 16476 PID_IL1_PATHWAY%MSIGDB_C2%PID_IL1_PATHWAY PID_IL1_PATHWAY 12362 93765 18412 111173 19697 26419 22034 16178 12675 26406 26409 16181 66589 266632 225471 18033 16151 16176 73914 26399 16180 18708 16177 18762 17874 18759 18706 16175 66513 68652 16150 16179 16476 54473 PID_RXR_VDR_PATHWAY%MSIGDB_C2%PID_RXR_VDR_PATHWAY PID_RXR_VDR_PATHWAY 12043 11303 20183 21803 21833 19401 218772 19411 67544 22260 19015 20182 20602 20186 21834 22337 19014 15370 20787 17977 22259 19016 21926 20181 19013 PID_IL2_1PATHWAY%MSIGDB_C2%PID_IL2_1PATHWAY PID_IL2_1PATHWAY 16451 16453 26419 17164 20844 21770 26417 20963 13449 26420 18708 56324 16185 11848 18706 14360 16476 14784 16184 110157 12043 15461 16183 16367 26395 12566 19229 26396 12703 20848 14389 19247 26413 14281 19094 20846 20416 12700 20850 18176 20851 20662 16818 15978 218397 16186 18751 16653 22780 12702 26416 18754 384783 17869 216233 PID_HNF3B_PATHWAY%MSIGDB_C2%PID_HNF3B_PATHWAY PID_HNF3B_PATHWAY 18534 12609 230163 22139 14377 20927 15375 15377 234724 15376 11657 11370 100040592 22042 12894 15107 11651 16334 12608 15378 12912 16006 20526 71911 11576 13386 18015 21405 11655 14061 18609 15227 21410 16514 78070 21869 103988 20683 12895 14815 22228 12606 11806 11364 18770 HALLMARK_APICAL_SURFACE%MSIGDB_C2%HALLMARK_APICAL_SURFACE HALLMARK_APICAL_SURFACE 11487 56406 20528 110380 80883 11820 64706 20312 73379 14451 68465 72043 58991 142681 21838 56315 14866 432442 54215 226250 17096 54670 237847 230872 15507 16186 20521 14595 72434 16185 14252 18793 14462 100102 17153 13846 12189 241035 140494 13640 11630 51795 74762 PID_TCR_JNK_PATHWAY%MSIGDB_C2%PID_TCR_JNK_PATHWAY PID_TCR_JNK_PATHWAY 12928 26410 16797 26411 26401 26419 26409 18751 26398 12929 13169 16476 16822 17444 BIOCARTA_ARENRF2_PATHWAY%MSIGDB_C2%BIOCARTA_ARENRF2_PATHWAY BIOCARTA_ARENRF2_PATHWAY 18750 18751 17134 17135 26413 14281 26416 12912 26419 17133 50868 16476 PID_IL12_STAT4_PATHWAY%MSIGDB_C2%PID_IL12_STAT4_PATHWAY PID_IL12_STAT4_PATHWAY 17344 16184 16183 19058 21803 18646 57765 26419 16163 20848 12519 14281 12500 12501 12502 12503 16173 15978 16362 12487 14968 104156 16174 26420 16182 14969 20849 12504 19055 19056 12914 12524 16476 HALLMARK_ANGIOGENESIS%MSIGDB_C2%HALLMARK_ANGIOGENESIS HALLMARK_ANGIOGENESIS 14182 14314 11820 22339 12825 17022 50706 16450 19074 14083 94185 22370 21857 268591 12444 20855 16410 20750 16956 12832 22325 20311 18186 108078 56744 21946 24059 16523 21824 20198 18590 17701 11818 16976 13003 16449 PID_S1P_S1P1_PATHWAY%MSIGDB_C2%PID_S1P_S1P1_PATHWAY PID_S1P_S1P1_PATHWAY 26417 16542 14687 19225 14681 18591 22339 20698 17250 19353 13609 16416 14679 11848 18803 26413 14677 18796 18596 16410 14678 PID_NCADHERIN_PATHWAY%MSIGDB_C2%PID_NCADHERIN_PATHWAY PID_NCADHERIN_PATHWAY 14182 12387 14158 18717 231871 26419 12801 269060 13043 14432 227753 19246 14800 13589 12325 19247 13191 18708 19877 19353 14609 17906 11848 16973 12558 18803 18706 12005 12388 16573 16480 12385 PID_P73PATHWAY%MSIGDB_C2%PID_P73PATHWAY PID_P73PATHWAY 30948 16451 19697 18817 12235 12448 22601 16396 18211 11576 11350 15214 18854 12190 14694 55948 12534 22431 22061 68048 12428 229933 56612 268882 12795 207742 319618 12125 18611 12028 15499 63958 22142 19361 12566 19645 23886 56484 18749 16450 14460 19094 14102 20703 223752 12018 80707 11486 18196 21945 226646 14651 83814 68098 16180 12649 14104 16190 12237 14252 23988 12366 81601 20683 93759 22062 26416 17246 19012 18787 12575 17869 12571 328572 BIOCARTA_ALK_PATHWAY%MSIGDB_C2%BIOCARTA_ALK_PATHWAY BIOCARTA_ALK_PATHWAY 12156 12387 12162 12168 17130 21803 12166 12159 17260 26409 11909 12160 12154 21405 14463 21808 17128 21812 21813 21809 21814 17906 18091 11477 19687 22408 12667 11789 18121 13542 12005 17129 14362 56637 230899 17125 BIOCARTA_TOB1_PATHWAY%MSIGDB_C2%BIOCARTA_TOB1_PATHWAY BIOCARTA_TOB1_PATHWAY 15978 16184 12487 17128 16183 21808 21812 21813 21809 21803 21814 17127 12500 12501 12502 57259 12503 22057 16189 PID_AMB2_NEUTROPHILS_PATHWAY%MSIGDB_C2%PID_AMB2_NEUTROPHILS_PATHWAY PID_AMB2_NEUTROPHILS_PATHWAY 15235 12143 21894 22612 20345 11651 18815 11596 17395 16971 18033 434174 19882 18791 83964 16818 17390 16193 21838 17096 19877 18762 14219 11848 16409 18793 21926 16414 14191 67374 15162 109905 14360 18792 20779 238055 20344 215449 15894 17882 BIOCARTA_GCR_PATHWAY%MSIGDB_C2%BIOCARTA_GCR_PATHWAY BIOCARTA_GCR_PATHWAY 18127 16952 11555 18708 14688 19697 30955 15519 11651 14815 14699 640703 18706 53419 18033 230899 PID_FOXO_PATHWAY%MSIGDB_C2%PID_FOXO_PATHWAY PID_FOXO_PATHWAY 14103 12387 100039786 64143 14377 19651 12125 15235 19384 26419 12566 18817 22628 22631 12675 54401 56484 11651 27401 70425 93687 104318 67731 27373 22682 103573 18519 20393 22629 103236 252870 56458 56044 214897 22627 26420 26414 55948 12359 93759 12914 12576 12053 13197 16150 54601 328572 20656 PID_ATR_PATHWAY%MSIGDB_C2%PID_ATR_PATHWAY PID_ATR_PATHWAY 19361 12566 18817 106344 243369 22631 72151 54401 27354 235559 66131 21853 54380 69263 214552 269582 19718 103583 68275 235610 19355 72930 19052 19367 19356 51792 12649 12190 211651 15574 23834 17220 12530 17246 17216 12532 19891 12428 PID_MYC_ACTIV_PATHWAY%MSIGDB_C2%PID_MYC_ACTIV_PATHWAY PID_MYC_ACTIV_PATHWAY 21752 18148 13557 18263 17127 27354 20713 67025 17395 14283 380669 108143 56426 18712 18103 75597 67014 21429 170676 17187 20425 67154 12151 72504 12035 20613 64602 12567 67065 72195 208643 15525 109115 12530 56505 68632 56456 13806 13665 69719 16828 15510 12028 66942 11757 22042 15519 100683 20525 14534 13684 216185 66464 13681 21877 12444 17128 59026 20174 116870 11799 15902 100088 15361 100043349 81601 14732 18642 12914 22059 18102 17869 328572 PID_FGF_PATHWAY%MSIGDB_C2%PID_FGF_PATHWAY PID_FGF_PATHWAY 14182 12550 70584 13043 11651 12322 17395 15234 14173 26417 18708 18803 18706 17295 14183 171463 17967 83379 16476 14186 14784 24064 14164 14172 64654 20111 231637 19229 14170 14177 18607 14179 19247 14171 26413 14180 14281 20846 20416 20750 20851 14184 20662 14175 12393 327826 18793 15529 12558 12388 12402 14388 18792 20779 BIOCARTA_AKAPCENTROSOME_PATHWAY%MSIGDB_C2%BIOCARTA_AKAPCENTROSOME_PATHWAY BIOCARTA_AKAPCENTROSOME_PATHWAY 19052 19088 19045 19087 19082 11848 18749 445007 12534 18754 320795 100986 18541 HALLMARK_KRAS_SIGNALING_UP%MSIGDB_C2%HALLMARK_KRAS_SIGNALING_UP HALLMARK_KRAS_SIGNALING_UP 26411 20230 18612 67603 18791 23871 21938 11421 21956 16878 83397 57264 24064 22029 19225 20568 12349 14396 21929 12444 20716 11501 16176 15902 16197 67776 18793 16154 12267 20347 57875 11796 16600 18792 11815 71683 56195 74145 17954 101772 19734 76816 20614 170744 67888 30951 20266 240832 16792 12183 12493 67778 545366 268980 73379 19378 56068 18826 22217 228662 66390 16534 66058 77125 16658 14584 78303 72088 58205 107527 66795 18616 67468 18671 14009 14425 21912 27260 230734 223272 233744 71891 13602 16574 217410 66805 72309 14257 14747 23882 12628 16398 65963 23957 19092 57349 74114 58860 50527 16186 16414 18613 16323 19662 15483 17087 16480 66066 19653 216019 78937 106052 18109 60596 74320 68927 17761 20682 18080 78560 14127 84094 18703 72972 93695 69008 26888 26359 56847 12142 15431 233315 71665 17395 18933 228576 20440 234309 64297 12683 13823 21990 170757 246196 17384 15945 17385 12982 15900 66109 18546 13805 211770 56743 71972 21788 19279 22778 22421 16002 14012 15200 14180 11846 12981 12876 13874 20750 12223 13844 20186 20297 11732 16913 12156 13040 14020 20394 14962 11652 30052 11491 79221 18049 18186 20255 93692 16009 12767 13730 26401 20616 14373 104156 94176 17872 14063 29809 12402 19699 BIOCARTA_NDKDYNAMIN_PATHWAY%MSIGDB_C2%BIOCARTA_NDKDYNAMIN_PATHWAY BIOCARTA_NDKDYNAMIN_PATHWAY 233489 30948 13858 18103 104015 13854 19057 218038 19055 19056 11773 13429 20975 640703 11771 18102 HALLMARK_UV_RESPONSE_UP%MSIGDB_C2%HALLMARK_UV_RESPONSE_UP HALLMARK_UV_RESPONSE_UP 20429 106344 14419 51810 20182 16362 22117 14825 13350 12824 13039 17713 17387 12227 15368 18550 14228 20887 11828 11546 12577 13559 14172 18412 11910 12447 22042 12566 12445 12349 27053 22275 18747 14281 16511 16193 13385 14778 12799 11891 59041 11674 102857 15370 12660 18091 15587 17701 11739 18213 20656 12156 13849 18035 59001 15512 12583 14261 19713 21338 12215 13076 18753 21354 70767 71765 16008 113868 11655 18391 81489 53324 110835 22174 18671 71844 22145 20867 100040519 66168 66427 17308 50776 15566 231327 15379 245841 14156 15270 231887 12611 66335 56200 56437 74325 110960 55938 17961 72017 11852 12122 12724 239528 16477 12125 17075 73340 99681 20751 14528 19419 16870 14660 20364 240095 12367 433375 105675 71702 53319 14282 19063 103963 19182 16195 110213 217869 26905 56418 15502 232910 66144 13728 22404 60597 12018 59045 12424 110920 667301 73122 56177 12579 12226 17096 13807 216869 12228 17161 216150 15894 14411 ST_PAC1_RECEPTOR_PATHWAY%MSIGDB_C2%ST_PAC1_RECEPTOR_PATHWAY ST_PAC1_RECEPTOR_PATHWAY 11886 228550 12796 14682 320404 14459 13138 BIOCARTA_EXTRINSIC_PATHWAY%MSIGDB_C2%BIOCARTA_EXTRINSIC_PATHWAY BIOCARTA_EXTRINSIC_PATHWAY 110135 14068 14161 19123 14062 99571 14067 14061 11905 21788 19128 14066 14058 PID_INTEGRIN_CS_PATHWAY%MSIGDB_C2%PID_INTEGRIN_CS_PATHWAY PID_INTEGRIN_CS_PATHWAY 16420 16407 16411 16404 16398 16402 241226 16412 16403 213119 381924 319480 109700 16401 104099 16410 16421 16419 320910 16400 16416 16399 16408 16409 16414 192897 BIOCARTA_SPRY_PATHWAY%MSIGDB_C2%BIOCARTA_SPRY_PATHWAY BIOCARTA_SPRY_PATHWAY 13645 26417 24064 110157 15461 218397 26395 13649 24066 26413 12402 20416 20779 236576 19263 14784 24063 20662 PID_SHP2_PATHWAY%MSIGDB_C2%PID_SHP2_PATHWAY PID_SHP2_PATHWAY 232906 16451 16453 18591 17356 16000 16001 16194 18049 18211 18596 18708 16185 11848 14679 78405 18205 12064 18706 14677 14784 13645 16184 110157 18127 15461 16183 15979 16542 94212 16367 26395 26396 22339 13649 11600 16195 14389 19247 18747 16452 20846 20416 21687 18176 20662 16818 16193 15978 327826 16911 107971 16186 15529 16653 14388 18212 18213 HALLMARK_PANCREAS_BETA_CELLS%MSIGDB_C2%HALLMARK_PANCREAS_BETA_CELLS HALLMARK_PANCREAS_BETA_CELLS 20927 15376 18506 18481 23797 16334 16658 20526 11925 21405 20818 56458 18609 22337 16909 20813 69019 53626 18508 103988 18012 14378 77766 20604 15874 18548 18088 16392 56529 12652 13482 20910 214189 80976 27058 13193 18770 14526 18549 18096 BIOCARTA_IGF1MTOR_PATHWAY%MSIGDB_C2%BIOCARTA_IGF1MTOR_PATHWAY BIOCARTA_IGF1MTOR_PATHWAY 13665 19211 19052 67204 18708 16332 224045 11651 13684 16000 667739 18607 16001 26905 18706 13685 18604 56717 56637 BIOCARTA_ERK5_PATHWAY%MSIGDB_C2%BIOCARTA_ERK5_PATHWAY BIOCARTA_ERK5_PATHWAY 26417 15461 20111 18708 30955 17260 11651 17258 23939 18803 26413 18706 17261 12912 18211 20416 14784 PID_AP1_PATHWAY%MSIGDB_C2%PID_AP1_PATHWAY PID_AP1_PATHWAY 15251 12387 21803 21823 13406 18619 16153 12017 17750 17395 12912 21857 14283 13614 14284 23871 20293 83995 14609 15007 16478 12534 12576 23857 16476 19211 16183 17863 16477 12125 11606 11910 14282 11909 19252 14281 12981 26754 13709 16193 15978 18019 18018 16191 67405 11459 22051 13653 382056 21416 18021 13982 12578 14815 20683 17134 14461 17132 12400 11770 22059 18792 17869 328572 230899 12443 12843 16189 16007 BIOCARTA_MTOR_PATHWAY%MSIGDB_C2%BIOCARTA_MTOR_PATHWAY BIOCARTA_MTOR_PATHWAY 19211 19052 18708 22084 230861 13690 208643 11651 667739 13684 13681 17346 18607 75705 18706 13685 13669 64930 18604 56717 14225 13682 PID_ERBB4_PATHWAY%MSIGDB_C2%PID_ERBB4_PATHWAY PID_ERBB4_PATHWAY 13869 15200 11491 26413 100042150 12398 22601 16452 16396 16206 17999 20416 74769 13874 80707 13866 20850 107568 20851 12223 19116 26417 13385 18708 18710 18709 14812 83961 20185 211323 19109 18183 18706 17246 68652 14360 14784 18707 BIOCARTA_EGF_PATHWAY%MSIGDB_C2%BIOCARTA_EGF_PATHWAY BIOCARTA_EGF_PATHWAY 18750 13645 110157 15461 100039026 16451 26395 26401 26419 20807 13649 20848 14281 13712 20846 20416 20850 20851 20662 26417 218397 18708 20849 20852 20847 26398 18751 18803 18706 16476 14784 PID_FOXM1_PATHWAY%MSIGDB_C2%PID_FOXM1_PATHWAY PID_FOXM1_PATHWAY 12447 26395 12566 21802 18817 20877 19645 22594 27401 14451 12615 14281 16775 17390 14235 104156 12616 54124 11799 12190 12567 18005 18021 606496 13982 12578 12442 20683 108000 15379 12534 12914 12531 50883 17869 328572 12443 12428 PID_BARD1_PATHWAY%MSIGDB_C2%PID_BARD1_PATHWAY PID_BARD1_PATHWAY 18148 18538 12447 19361 225182 22195 12566 66105 27354 14087 235559 19360 100040608 60534 14030 72775 12021 67337 67030 22596 211651 14375 14088 11920 19090 17535 22059 12189 PID_AVB3_INTEGRIN_PATHWAY%MSIGDB_C2%PID_AVB3_INTEGRIN_PATHWAY PID_AVB3_INTEGRIN_PATHWAY 78560 12370 12825 11651 16000 16001 57257 22370 12834 12819 16410 16456 12815 26417 14173 12833 12977 18708 12818 12829 19877 12839 12828 94216 12824 12830 20969 30924 19353 12826 12816 11848 12831 18706 12576 19303 12927 107581 329941 16542 12837 16367 17304 21894 12840 19229 12821 22339 12841 15519 12842 12817 12813 19247 14083 26413 14268 12814 13612 12835 20750 12832 18704 224020 21813 107650 16416 12836 16202 12402 22330 12978 20779 12843 BIOCARTA_CARM1_PATHWAY%MSIGDB_C2%BIOCARTA_CARM1_PATHWAY BIOCARTA_CARM1_PATHWAY 18749 12914 17979 12912 19088 59035 20181 19401 19084 19087 328572 19085 HALLMARK_TNFA_SIGNALING_VIA_NFKB%MSIGDB_C2%HALLMARK_TNFA_SIGNALING_VIA_NFKB HALLMARK_TNFA_SIGNALING_VIA_NFKB 74646 67916 56706 14345 57783 67035 22113 56722 16601 71712 75234 17127 21815 227659 20620 13660 15936 18626 17691 14579 319520 15939 19696 17681 16598 14221 20918 20893 14283 104681 18024 14284 56336 55991 23872 12522 26410 21664 17133 20971 16878 18030 12609 22029 18412 22695 15205 11910 19225 170768 20725 67972 21929 23849 16193 16176 321019 99929 54446 15902 16197 108767 18793 15937 20527 18787 11796 12575 14066 16600 18792 16449 16835 16007 12633 14584 20311 21930 26397 19219 230073 18578 12515 59027 17118 230734 11852 14528 22339 21847 17873 14282 12608 21928 230738 216850 12778 12047 12226 12228 21926 240672 12051 16175 16323 13197 17869 15894 12443 11303 13655 13654 19697 20698 20621 13537 15945 16362 20310 21923 20293 12977 16780 20303 56193 56066 14825 19698 108078 192656 24088 12227 19288 211770 11839 13636 16476 11797 54199 56376 18081 71586 15200 70789 231130 14281 12981 20850 20304 65112 20297 229055 83430 15370 14595 106869 20229 15958 106628 21807 56708 20656 12156 22151 18035 17210 12519 18033 13614 19267 21354 18788 18037 21942 18034 50723 18227 330122 17119 19347 16477 15980 54720 16169 16195 19252 14373 20393 16160 16173 12505 18124 17872 13653 14063 21353 12702 12053 384783 PID_PS1_PATHWAY%MSIGDB_C2%PID_PS1_PATHWAY PID_PS1_PATHWAY 11487 18099 12387 100039026 208117 243369 56811 13016 73016 19164 100039623 26409 19664 100042305 59287 93687 13388 93960 26413 18128 14281 14357 103583 17999 433759 21770 19015 13380 26417 21405 21885 14797 24117 14296 16974 22408 12914 11789 13542 66513 12005 14362 56637 17869 16476 12443 PID_INTEGRIN4_PATHWAY%MSIGDB_C2%PID_INTEGRIN4_PATHWAY PID_INTEGRIN4_PATHWAY 16779 16777 16773 226519 16403 16780 192897 16776 16772 16774 16782 BIOCARTA_THELPER_PATHWAY%MSIGDB_C2%BIOCARTA_THELPER_PATHWAY BIOCARTA_THELPER_PATHWAY 16408 21838 12487 16414 12500 12501 12504 12502 12503 15894 19264 12481 ST_WNT_CA2_CYCLIC_GMP_PATHWAY%MSIGDB_C2%ST_WNT_CA2_CYCLIC_GMP_PATHWAY ST_WNT_CA2_CYCLIC_GMP_PATHWAY 16439 228550 54446 14962 16438 110855 18588 14412 78600 225600 12322 108058 12323 12325 18582 16440 320404 18587 22041 13138 PID_HDAC_CLASSIII_PATHWAY%MSIGDB_C2%PID_HDAC_CLASSIII_PATHWAY PID_HDAC_CLASSIII_PATHWAY 22151 12028 64384 19017 14200 56484 68738 17261 17927 18519 56458 64383 14375 208727 60525 15395 22143 50709 93759 209011 12914 12575 22059 54601 328572 PID_INTEGRIN3_PATHWAY%MSIGDB_C2%PID_INTEGRIN3_PATHWAY PID_INTEGRIN3_PATHWAY 16542 226519 18591 16728 20698 22339 12842 22370 14268 15891 13612 16775 434174 18596 21825 16423 16410 20750 16456 110135 16777 21838 21923 14161 99571 14118 21813 12829 12828 94216 12830 20969 16416 12826 16399 20971 18793 18613 21810 18792 12843 16007 HALLMARK_PI3K_AKT_MTOR_SIGNALING%MSIGDB_C2%HALLMARK_PI3K_AKT_MTOR_SIGNALING HALLMARK_PI3K_AKT_MTOR_SIGNALING 110651 22030 21844 26419 70584 69008 17347 17346 100040260 57257 12326 13001 13198 13555 26420 18710 26414 12567 17973 17874 21937 12283 18803 14699 210044 18711 73699 56480 12576 72349 66350 75778 14784 228775 18412 12566 20525 14177 26409 19247 14171 12631 18643 12575 16189 16439 20491 18036 110355 228026 66105 11651 12317 266632 18049 22027 192662 67112 74370 67605 55948 26397 26940 19353 20847 11773 19766 12534 67300 18741 227743 11840 56637 12767 19211 107607 110157 14103 15461 20111 64143 93765 22084 107476 54401 19082 13684 13649 108079 26413 16818 26377 26399 19769 16186 19045 19087 14675 23988 66713 18751 17126 18795 56378 74117 BIOCARTA_RAS_PATHWAY%MSIGDB_C2%BIOCARTA_RAS_PATHWAY BIOCARTA_RAS_PATHWAY 26417 110157 15461 56044 18708 18805 30955 19697 26395 12015 12048 19353 12675 12371 11651 11848 19765 18706 13712 18033 54601 19730 PID_CDC42_PATHWAY%MSIGDB_C2%PID_CDC42_PATHWAY PID_CDC42_PATHWAY 12387 12550 18805 29875 22612 21844 26419 70584 13860 13383 22325 18000 26417 54126 192662 26420 26400 18708 108100 404710 18762 26397 224105 19353 16885 17906 26398 18706 14064 11789 56637 56513 26403 56419 73178 16476 15208 73341 12927 226751 110157 15461 109880 26401 11909 18479 26413 56717 26399 16886 51789 19417 18508 66713 53413 76709 68089 12631 26416 67771 18754 12402 20779 56378 74117 11867 12385 BIOCARTA_CALCINEURIN_PATHWAY%MSIGDB_C2%BIOCARTA_CALCINEURIN_PATHWAY BIOCARTA_CALCINEURIN_PATHWAY 18750 18019 18018 73181 19057 14682 19055 19056 18021 20683 18751 20687 18803 640703 17118 12575 HALLMARK_DNA_REPAIR%MSIGDB_C2%HALLMARK_DNA_REPAIR HALLMARK_DNA_REPAIR 106344 18588 72151 69263 19718 108143 69833 20022 66420 67710 69241 209357 17749 20021 70239 67967 20922 69920 22591 27632 74414 69870 110074 11512 17129 20020 22088 27369 54208 75062 18970 68134 13135 53421 14923 13870 66162 15452 19361 228410 74167 69020 13194 27061 19365 74164 216185 27224 66464 58202 69745 18968 22169 20924 13716 16881 22592 50505 22171 53378 66406 21343 99730 72269 194309 235459 68092 330959 11486 68240 57314 66914 107939 57278 16434 98985 625249 56044 330192 66979 19075 56520 21341 21357 80905 26370 66653 18971 11636 107986 20930 13871 13872 54722 59022 19714 230103 57813 66467 52696 76850 66136 107569 67897 223921 18100 21681 227644 70456 20018 67665 20016 12856 218630 98053 100042343 20908 66679 14884 11821 71991 79059 50773 94223 229906 105446 56248 68969 67996 68219 382985 56626 100042069 18578 245841 14156 20833 56436 19891 15163 18538 76025 18950 268395 56438 236733 18969 22247 22059 18102 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY%MSIGDB_C2%ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY 19159 19211 20111 100039786 20663 110651 228026 66583 21981 11652 22628 22631 23797 54401 11651 16331 20416 16006 117586 22629 20662 26377 56458 22627 20112 18124 55948 12015 606496 12578 18706 12229 56637 14784 105148 BIOCARTA_VEGF_PATHWAY%MSIGDB_C2%BIOCARTA_VEGF_PATHWAY BIOCARTA_VEGF_PATHWAY 13665 18750 15251 15461 18127 14254 22346 16542 66235 14257 22339 15568 217715 13667 26905 14083 20918 20416 108067 209354 67204 11863 18708 30955 224045 18751 18803 18706 19303 BIOCARTA_TPO_PATHWAY%MSIGDB_C2%BIOCARTA_TPO_PATHWAY BIOCARTA_TPO_PATHWAY 18750 26417 110157 15461 218397 100039026 18708 30955 26395 20848 18751 17480 21832 18803 14281 18706 16452 20846 20416 20850 16476 20851 14784 20662 BIOCARTA_CDC42RAC_PATHWAY%MSIGDB_C2%BIOCARTA_CDC42RAC_PATHWAY BIOCARTA_CDC42RAC_PATHWAY 18708 19353 11848 66713 18595 18479 56443 76709 18706 68089 67771 73178 56378 74117 11867 BIOCARTA_MTA3_PATHWAY%MSIGDB_C2%BIOCARTA_MTA3_PATHWAY BIOCARTA_MTA3_PATHWAY 69253 12550 116870 22142 22145 11674 13033 15507 20613 59020 22147 100043349 13982 116871 22146 20583 433759 17192 BIOCARTA_ARF_PATHWAY%MSIGDB_C2%BIOCARTA_ARF_PATHWAY BIOCARTA_ARF_PATHWAY 20018 20016 13555 18708 22160 30955 21385 19645 19353 12578 18706 20019 20017 17246 22059 17869 11350 BIOCARTA_EIF_PATHWAY%MSIGDB_C2%BIOCARTA_EIF_PATHWAY BIOCARTA_EIF_PATHWAY 13665 67204 66235 230861 13690 16418 208643 13684 13681 13631 217869 13629 26905 13669 20918 13682 PID_PI3KCI_AKT_PATHWAY%MSIGDB_C2%PID_PI3KCI_AKT_PATHWAY PID_PI3KCI_AKT_PATHWAY 110157 100039786 20528 78757 11652 22628 15519 12048 22631 12675 23797 54401 56484 12371 11651 210789 26408 18607 18747 56717 56716 22629 56458 22627 16646 55948 12015 606496 12576 19090 227743 12575 56637 20779 54601 PID_P53_DOWNSTREAM_PATHWAY%MSIGDB_C2%PID_P53_DOWNSTREAM_PATHWAY PID_P53_DOWNSTREAM_PATHWAY 13557 57913 59035 21981 12142 15234 108143 13555 21781 12227 16878 17295 13207 16476 13836 12795 15248 12362 11910 21802 19645 26921 20312 60599 100683 14534 23886 14102 20583 17988 20750 13380 12177 68098 20586 12450 110750 218215 107986 20683 17685 11783 14149 22062 12914 13003 18787 12575 15182 328572 15375 18044 18045 94223 26374 17210 382985 11576 21354 17390 68428 71887 57748 12454 18854 12607 17350 67941 140742 22178 22337 55948 66813 14000 319801 29813 235281 64058 18861 12050 21933 13496 268973 16009 209456 11789 59092 22061 71361 66214 69076 13615 66824 74747 20400 15469 18046 15194 19211 12368 12062 12043 12122 12389 12028 18538 22084 27056 12048 13649 19252 14775 18997 19079 12018 242705 12047 18996 12521 13033 240672 12822 17246 12053 20724 22059 13197 BIOCARTA_RAC1_PATHWAY%MSIGDB_C2%BIOCARTA_RAC1_PATHWAY BIOCARTA_RAC1_PATHWAY 76932 18708 83767 18805 30955 107589 26401 17970 16885 22324 17906 19353 329251 18595 19765 18479 223435 18706 12631 12568 12569 NABA_ECM_GLYCOPROTEINS%MSIGDB_C2%NABA_ECM_GLYCOPROTEINS NABA_ECM_GLYCOPROTEINS 16773 20563 13406 20692 16772 11603 70370 100689 22370 11568 231470 68655 320181 234199 14190 14119 17150 29817 23876 16779 21923 114249 14118 16780 16776 16774 20562 68588 11450 17313 320712 22402 14268 15891 13612 18208 23928 16006 21825 16782 20750 110135 14161 99571 67776 71768 328643 70853 69882 192199 232585 27762 22403 21810 16007 51795 239852 22787 22788 75718 18133 226519 22786 22371 80883 243967 57764 18209 170721 229389 18419 18302 50706 69675 18542 76477 17182 17181 17180 108075 216760 100034361 11698 94111 17183 105450 338352 70945 76293 18074 16008 68169 207596 54003 21827 26944 329278 21828 94242 21960 252974 21930 81877 22283 14114 240675 244152 233813 74199 246228 226866 228770 72780 16009 239405 208777 64074 64075 20564 233744 13602 21684 21683 64817 140703 14115 280635 16010 17304 68792 407800 216616 243369 100952 246707 13717 13601 50530 56429 12945 268780 58859 16775 236790 382864 83691 78892 666279 50766 214425 16777 18073 68709 171508 12845 242603 76737 330470 73230 16997 16998 11704 12810 21826 246316 14219 56839 333088 242050 268977 76905 243914 213469 665700 14456 235379 19699 78919 75426 16012 16011 16005 PID_RHOA_REG_PATHWAY%MSIGDB_C2%PID_RHOA_REG_PATHWAY PID_RHOA_REG_PATHWAY 13605 52666 50768 109934 232906 53972 72754 69710 17925 73167 216445 117600 106952 23853 56349 110596 213522 109904 57257 14570 223254 22325 71704 102098 192662 16801 442801 75547 110279 69632 11855 22324 11848 223435 16800 11857 12576 213498 207212 94190 234094 17207 11856 171207 ST_JNK_MAPK_PATHWAY%MSIGDB_C2%ST_JNK_MAPK_PATHWAY ST_JNK_MAPK_PATHWAY 26401 13382 26419 22034 26406 11651 26409 23939 22026 26408 11909 319520 26407 269881 20416 338372 23938 26405 71751 26404 26420 26400 26414 16177 17876 65964 18021 103988 18491 26398 18218 63953 66513 68652 22059 14388 13197 26403 16476 HALLMARK_GLYCOLYSIS%MSIGDB_C2%HALLMARK_GLYCOLYSIS HALLMARK_GLYCOLYSIS 17859 14733 216558 20856 52231 14447 66681 11603 83553 26757 17319 30046 14042 20855 57444 117592 56012 50927 14385 21351 11541 27376 18484 20969 14828 13179 14228 21983 15366 17436 18451 17684 16833 23996 13806 230163 16828 22166 112407 58226 14734 236900 15277 14735 14936 20970 110611 74104 66171 14629 77559 18563 11674 56421 18194 14381 110006 15529 13638 18452 15937 57875 13003 21810 18655 105785 16765 109672 20878 12615 268373 18822 26432 60406 12534 22021 21786 24105 22339 12337 78330 23989 14719 13807 50527 635960 70186 14635 68507 66052 26384 23908 59031 17448 72727 74241 14120 17449 218271 17289 54128 20682 21991 110078 18639 50797 13382 104009 110119 107869 226413 76332 110095 22359 54371 74246 17295 11727 22122 76524 15926 56752 21802 59046 56863 14595 11876 667310 15932 19348 110094 56248 104458 93692 52187 12831 16009 74747 12767 12368 12124 23827 16164 76969 56773 13649 23897 208211 14583 76898 50798 58810 19139 50799 70601 18746 53418 107029 18648 14043 12505 229782 84111 69080 93683 53897 19053 67005 16876 56727 67311 232493 53618 80879 57357 331026 55982 13506 50786 14718 76131 23959 217119 56375 26887 12739 67451 16563 76429 72297 26556 384783 78688 110695 13710 83398 69976 66646 SA_G2_AND_M_PHASES%MSIGDB_C2%SA_G2_AND_M_PHASES SA_G2_AND_M_PHASES 12530 12534 12649 12531 12575 12572 18004 22390 PID_ERBB2_ERBB3_PATHWAY%MSIGDB_C2%PID_ERBB2_ERBB3_PATHWAY PID_ERBB2_ERBB3_PATHWAY 11435 110157 84092 15461 26395 18016 26396 26419 13867 67588 11651 11448 67299 20848 19247 18747 26413 14281 100042150 16452 56717 74769 20416 13866 18176 20662 26417 26420 73181 18708 18710 26414 18709 12015 19056 19353 211323 16653 18706 20779 16476 14784 18707 BIOCARTA_CELL2CELL_PATHWAY%MSIGDB_C2%BIOCARTA_CELL2CELL_PATHWAY BIOCARTA_CELL2CELL_PATHWAY 12387 216033 12386 14083 18613 19303 11474 109711 22330 20779 11472 12988 12385 12927 BIOCARTA_KERATINOCYTE_PATHWAY%MSIGDB_C2%BIOCARTA_KERATINOCYTE_PATHWAY BIOCARTA_KERATINOCYTE_PATHWAY 53859 13645 18750 110157 14103 12043 15461 18035 22030 26401 26395 19697 26419 12675 13649 26408 15404 26415 26413 14281 14102 18033 18753 23871 19052 21938 26417 13163 23872 26399 26400 26397 21937 19766 26398 18751 20683 21926 26416 12606 18754 18752 16150 18761 18755 16476 PID_INTEGRIN5_PATHWAY%MSIGDB_C2%PID_INTEGRIN5_PATHWAY PID_INTEGRIN5_PATHWAY 16420 21812 17123 14118 320910 20969 18793 22370 14268 13612 22329 18792 16401 16410 16421 16419 16007 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES%MSIGDB_C2%SIG_IL4RECEPTOR_IN_B_LYPHOCYTES SIG_IL4RECEPTOR_IN_B_LYPHOCYTES 110157 12043 16367 26411 20663 16451 228026 16453 21981 11652 12703 23797 11651 26413 20416 20662 26417 18708 16190 20852 12015 606496 18706 384783 56637 14784 18707 PID_NOTCH_PATHWAY%MSIGDB_C2%PID_NOTCH_PATHWAY PID_NOTCH_PATHWAY 11487 208117 11489 13016 19164 27401 19664 13388 53870 18128 16924 227325 13389 16396 225164 18011 56309 54485 12805 17150 13386 50754 18550 99982 26965 18129 13806 13858 19208 225182 243369 18131 16450 100039623 50530 18132 100042305 59287 270118 18222 14357 13728 433759 20602 56381 103806 20185 13429 14462 12402 12575 16449 17869 21402 328572 53869 22632 12443 16189 BIOCARTA_PLCE_PATHWAY%MSIGDB_C2%BIOCARTA_PLCE_PATHWAY BIOCARTA_PLCE_PATHWAY 18749 11555 19088 74055 19084 19087 74012 19085 19216 432530 PID_HIF1_TFPATHWAY%MSIGDB_C2%PID_HIF1_TFPATHWAY PID_HIF1_TFPATHWAY 15251 21752 18148 72157 17127 11651 15275 17210 15378 12912 20893 13614 79362 23871 230099 18671 15368 13805 18550 12767 20315 16476 17684 100042570 13806 18641 16828 21786 112407 11520 170768 22339 11535 22042 12870 19883 20525 15277 18126 16846 14151 14281 17988 18746 26754 16006 22041 17128 11863 11674 15902 17978 17977 103988 20683 23959 16414 14461 12914 18787 56233 18655 328572 13856 26357 PID_RHODOPSIN_PATHWAY%MSIGDB_C2%PID_RHODOPSIN_PATHWAY PID_RHODOPSIN_PATHWAY 12788 214111 14685 14688 212541 18588 77974 245650 19682 225600 79235 243923 14699 14913 107477 19739 20215 18587 14697 19892 14919 24013 PID_MYC_REPRESS_PATHWAY%MSIGDB_C2%PID_MYC_REPRESS_PATHWAY PID_MYC_REPRESS_PATHWAY 18044 18045 17127 22642 12633 12912 15360 18596 13866 13198 20377 56363 17122 15900 12192 17187 21374 94280 19650 18173 14319 23894 13435 21873 16852 66271 229663 192897 12576 22418 18046 12609 14581 12043 15183 56752 22084 12759 56484 21673 29811 16412 16403 17988 433759 20304 13380 17128 12579 15902 110854 20683 17126 12606 12575 13197 17869 20375 12189 328572 12443 12843 PID_REG_GR_PATHWAY%MSIGDB_C2%PID_REG_GR_PATHWAY PID_REG_GR_PATHWAY 110308 19697 26419 20588 16163 11651 12912 18033 11576 26417 16362 26420 21374 26414 16664 55948 12355 83995 19060 100043429 12991 14228 68094 18736 18514 83797 16667 74551 12568 12640 225888 56637 18976 12569 16476 22088 16183 12028 18986 57765 15519 18749 18747 26413 14281 19094 12981 20846 433759 20393 20850 22629 20851 16193 15978 20339 18018 16191 99571 20586 13653 15370 17978 17977 14815 19109 14462 14229 12914 26416 22354 17246 22059 12575 15182 20375 15894 328572 16189 BIOCARTA_CDMAC_PATHWAY%MSIGDB_C2%BIOCARTA_CDMAC_PATHWAY BIOCARTA_CDMAC_PATHWAY 18750 110157 26417 15461 18035 19697 26395 18751 21926 26413 14281 16433 18033 18795 17869 16476 BIOCARTA_P53HYPOXIA_PATHWAY%MSIGDB_C2%BIOCARTA_P53HYPOXIA_PATHWAY BIOCARTA_P53HYPOXIA_PATHWAY 15251 18104 15248 18036 12028 18671 270627 26419 15519 14200 11651 193740 11920 93687 104318 16009 17246 68275 22059 12575 13197 328572 PID_FCER1_PATHWAY%MSIGDB_C2%PID_FCER1_PATHWAY PID_FCER1_PATHWAY 18806 14158 19697 20698 26419 14127 13609 12675 11651 18033 14130 18783 16822 16151 26417 20963 26400 18708 224105 26398 56743 18803 18706 16428 19303 14360 16150 14125 16476 14126 215280 14784 50928 110157 15461 15163 18778 26401 26395 26396 16331 14389 19247 19252 26413 14083 14281 20416 20662 18019 218397 16797 17096 19249 22324 208650 13448 18751 19012 12229 12402 PID_ERBB1_DOWNSTREAM_PATHWAY%MSIGDB_C2%PID_ERBB1_DOWNSTREAM_PATHWAY PID_ERBB1_DOWNSTREAM_PATHWAY 50884 110651 29875 26419 76884 11308 23939 100040260 56613 17907 67603 12912 23938 242687 26405 22325 26420 18708 18710 18709 11843 18762 12015 19060 26398 18706 14064 56419 73178 16476 19730 17125 14784 18707 27371 22695 20848 14281 20846 225870 20662 56044 18806 23980 98910 18805 11651 74769 13860 18753 16706 26417 22627 108100 55948 19353 667739 73086 12334 227743 101314 13645 18750 110157 15461 100039786 109880 78757 26395 26401 26396 22628 12048 22631 17260 54401 13649 20807 18607 11909 19252 26413 13712 56717 56716 22629 18176 71978 19052 51792 13653 271457 20544 66713 16653 76709 68089 67771 14388 20779 56378 74117 11867 BIOCARTA_NOS1_PATHWAY%MSIGDB_C2%BIOCARTA_NOS1_PATHWAY BIOCARTA_NOS1_PATHWAY 18750 14811 13385 14814 14813 19057 19088 14812 19084 19055 19056 19087 19085 18749 18125 18751 640703 14810 BIOCARTA_KREB_PATHWAY%MSIGDB_C2%BIOCARTA_KREB_PATHWAY BIOCARTA_KREB_PATHWAY 18293 66945 20916 14194 17449 12974 269951 11429 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS%MSIGDB_C2%ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS 14539 13655 18705 17755 109880 21823 13654 110651 14682 22142 12913 14459 26419 11651 19247 100040260 26413 13712 12912 30957 18211 20416 60597 19099 13138 26417 327826 26420 19418 26400 18708 13656 26414 13653 11886 26398 18706 12796 57321 12929 12914 20779 16476 18707 BIOCARTA_MAL_PATHWAY%MSIGDB_C2%BIOCARTA_MAL_PATHWAY BIOCARTA_MAL_PATHWAY 110157 26417 15461 21405 19877 11459 26395 26401 26419 26396 26412 19353 16885 11848 20807 26413 17153 13367 PID_IL23_PATHWAY%MSIGDB_C2%PID_IL23_PATHWAY PID_IL23_PATHWAY 330122 17329 209590 16183 18035 16171 19697 18126 20848 12501 16452 20846 18033 16160 16173 20850 54721 16193 16176 15978 257630 16161 20293 17523 16174 16182 93672 18708 20849 12504 83430 16400 11686 21926 18706 12702 329244 PID_CDC42_REG_PATHWAY%MSIGDB_C2%PID_CDC42_REG_PATHWAY PID_CDC42_REG_PATHWAY 52666 53972 70497 319899 210293 75974 20403 227377 219140 109904 14163 19765 57257 16443 26934 22325 54126 192662 236915 29815 18803 71972 11789 228359 18102 216963 17207 73341 BIOCARTA_SKP2E2F_PATHWAY%MSIGDB_C2%BIOCARTA_SKP2E2F_PATHWAY BIOCARTA_SKP2E2F_PATHWAY 12427 13555 27401 21781 12447 216150 12566 26965 19645 21402 PID_IGF1_PATHWAY%MSIGDB_C2%PID_IGF1_PATHWAY PID_IGF1_PATHWAY 110157 15461 12928 16367 14783 19246 22631 11651 16000 18607 16001 19247 14083 20416 18760 18753 20662 22627 18708 14694 18762 12015 17974 18706 12929 19303 384783 14784 12927 NABA_MATRISOME_ASSOCIATED%MSIGDB_C2%NABA_MATRISOME_ASSOCIATED NABA_MATRISOME_ASSOCIATED 18591 16000 16334 21943 18791 20969 20390 20971 18451 17311 14071 50701 14734 12306 18654 14735 20970 21817 16193 16176 16191 20292 23845 112406 20354 15529 16322 20198 57875 18787 18792 16189 14560 14561 14562 14563 229574 14256 14168 21803 83554 387510 230405 668304 14181 224116 14174 121021 72514 14176 22035 14178 18489 71920 140571 81701 54712 353156 67784 54156 67709 54394 20346 381457 19693 100042150 19695 12919 108151 14167 20349 14166 20350 14165 218877 56636 20356 80857 20352 14169 20351 13607 20353 20311 20357 215257 20355 58181 26456 257630 20360 140806 214968 54450 20358 54448 20359 93672 20388 69677 20361 17700 20389 18188 319909 56620 27356 170779 269878 75863 230971 51811 230316 56619 18119 17474 14566 21922 78405 381809 12064 665180 238057 403395 239114 243653 215274 56760 56069 71183 22408 234836 353287 16325 20256 16324 66864 329244 17312 16336 232413 67933 109323 242316 239126 76527 227580 15161 239659 58992 326623 13645 50930 216505 240873 54612 20319 16952 71325 99681 268686 12309 268935 22339 64706 385643 12153 22423 22412 20203 109910 214058 320202 217738 13590 15977 20197 20200 20199 19692 70417 20194 20196 17393 20703 67860 66166 19197 57349 20193 20129 16948 320460 16963 278507 235611 21926 215001 22164 12985 22410 319922 16175 22018 16323 12165 16156 11502 12258 16426 93735 26888 26359 11504 21816 217847 20377 17384 20890 17385 22413 20379 22409 17175 22411 56213 22341 17287 14205 13036 20296 13038 14825 13039 17387 16852 14060 229445 11705 21949 11839 13363 16147 15245 22416 22417 22414 17388 22415 22420 22421 17394 22418 21859 22419 216795 22422 20201 14164 14172 64654 16002 22340 15235 20378 13019 14314 15200 23794 21802 20312 17242 20202 23886 14170 14177 14179 16181 14171 14180 12160 12154 19242 20295 116849 23792 21944 13874 26360 20304 12223 12404 215378 56410 12405 12163 20297 240843 24117 110075 12155 83430 83961 70726 72713 11876 654812 12803 59007 69121 20299 21832 12931 16858 57266 18183 56708 228942 20290 100039973 100038965 56221 56838 70361 20302 320924 13040 170786 11490 21808 18788 67112 80903 23919 18205 14573 20315 11606 16160 16173 16159 15978 11746 13034 620395 14733 230398 16171 16170 11905 16153 16163 16168 11489 16198 16992 140570 210530 11495 14789 16716 83995 16878 18590 16854 13011 13012 15160 20723 73720 76770 112407 58214 319433 20720 74468 20568 20725 116872 18816 20195 20317 240725 68054 11747 380780 69787 331535 12406 67931 72043 19143 66222 71907 20248 394252 268591 20716 66957 241197 14175 16949 11501 16950 94352 67573 209378 107250 56401 109685 77042 16425 215015 80752 226243 545291 78558 13032 13041 228756 19025 330723 18452 56464 15587 15586 20347 13013 13014 67868 13030 71756 78240 13010 64138 208659 11487 74145 14068 15442 12401 240322 216725 223838 330119 110595 21892 21818 331046 74176 241636 13522 20713 208936 271127 235505 215095 54426 13706 69066 30806 109901 108154 240913 224697 108153 279028 239337 235130 237360 14058 26433 19142 18822 26432 58223 23948 22072 17389 20300 320452 74443 20348 241196 71869 30924 18552 18553 210622 23850 24087 18491 270086 66627 21858 640543 19146 17288 26561 17391 30800 214766 20719 234911 118453 240047 17829 71790 11488 11496 11492 13524 58860 11500 71078 244486 110751 13033 353188 11699 66548 229595 269959 77794 77739 19109 20724 56622 24099 69583 71785 17386 17395 15234 15945 18413 20310 20293 50498 12977 16196 20303 56066 20306 56744 232345 16424 94175 16427 17195 71693 239447 232414 11600 56644 207393 18815 243312 29873 140792 14134 12981 59308 216551 16429 71951 333315 242022 11602 329872 17063 235416 56072 107753 16855 23888 103978 15458 13035 353328 140474 12659 17381 269328 17392 73732 100039649 16859 56048 18844 11744 72324 67448 12161 243743 231440 18845 18846 56745 69183 23829 226359 11752 11749 11745 11750 12156 12162 20387 12159 12262 11491 20423 21857 18049 17390 14173 11601 14061 12259 211323 12260 12667 23892 14313 330122 17329 14103 16326 16183 16994 54635 16846 55985 21809 13856 HALLMARK_APOPTOSIS%MSIGDB_C2%HALLMARK_APOPTOSIS HALLMARK_APOPTOSIS 12387 13655 19697 11820 66593 107869 13867 227753 20230 17022 12427 19165 15234 18596 18791 14919 13866 57444 13198 16362 100037258 19877 12475 12227 13179 15368 16854 12576 21859 16476 13347 27279 12362 18611 18412 54140 18646 11910 12566 56338 12759 27061 228355 74256 12111 14102 13874 12444 14863 16193 16176 14778 625249 12177 235293 13595 20229 11732 667310 15937 14149 12914 66141 11518 11796 12575 12189 12042 14958 20656 74006 12156 235180 17314 24014 72168 22334 99586 223453 229791 20515 12049 171543 12370 12633 214952 20740 18003 22035 19164 17210 225363 14782 12369 12257 21857 67442 21973 21354 17390 21808 14061 18569 15507 12515 12050 21858 16842 65111 12531 380684 225849 12368 14103 12124 12122 11852 14062 15979 16952 12125 16004 12389 12028 19058 13730 14528 19401 12048 12367 17873 12481 16668 12371 19063 15977 18479 14775 14083 12494 15502 16173 12505 21814 13807 11798 12228 16905 12366 17131 21926 12363 14676 16175 18796 97165 13197 16012 12443 22390 BIOCARTA_SRCRPTP_PATHWAY%MSIGDB_C2%BIOCARTA_SRCRPTP_PATHWAY BIOCARTA_SRCRPTP_PATHWAY 18750 12530 18751 12534 12531 19262 20779 12532 14784 12988 ST_JAK_STAT_PATHWAY%MSIGDB_C2%ST_JAK_STAT_PATHWAY ST_JAK_STAT_PATHWAY 19273 19692 16451 16452 16453 229615 20652 56469 12700 BIOCARTA_P38MAPK_PATHWAY%MSIGDB_C2%BIOCARTA_P38MAPK_PATHWAY BIOCARTA_P38MAPK_PATHWAY 69253 15461 21803 22030 26401 71609 17260 17258 17164 26409 26408 11909 17346 17261 13712 12912 20846 338372 20416 18783 17165 76089 13198 13163 21808 26399 21812 21809 17187 15507 19353 19766 26398 73086 26416 17869 14784 PID_WNT_NONCANONICAL_PATHWAY%MSIGDB_C2%PID_WNT_NONCANONICAL_PATHWAY PID_WNT_NONCANONICAL_PATHWAY 18099 192176 22612 26419 12322 26409 93687 14367 208846 14369 18019 26420 13544 19877 26414 18762 68588 216869 19353 11848 13543 19016 66513 13542 26564 14368 68652 84505 22418 57265 320790 PID_ERBB_NETWORK_PATHWAY%MSIGDB_C2%PID_ERBB_NETWORK_PATHWAY PID_ERBB_NETWORK_PATHWAY 13645 13869 15200 21802 83961 13867 15519 211323 13649 11839 100042150 18183 13874 13866 12223 BIOCARTA_PTC1_PATHWAY%MSIGDB_C2%BIOCARTA_PTC1_PATHWAY BIOCARTA_PTC1_PATHWAY 12530 19206 12534 20423 12531 103573 17420 12532 66671 12572 HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION%MSIGDB_C2%HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION 16773 14264 14733 20692 20563 16772 21345 104009 16168 11489 12825 17022 20745 71665 14579 18933 16971 12834 18596 16410 14119 18858 16419 23876 20377 21923 20379 56213 14118 22341 24053 107589 16774 20969 83995 17387 68588 14609 12826 16852 20971 12827 19035 12816 13179 19288 22004 11839 17313 53867 18645 22418 21859 16476 320712 215280 17294 24052 27279 20720 14314 12842 21929 12111 12563 12406 16402 14370 14451 16412 19227 14268 13612 20583 14102 22329 12835 21825 16782 20750 21817 12832 67268 16949 16193 65112 13380 94352 54725 56401 102857 13732 15902 17392 20229 16416 18793 12558 12931 17701 16790 13003 18787 21810 12843 16007 192176 226519 21803 83554 22352 50706 12332 18542 76477 17182 18383 17181 21857 20311 13132 26433 18074 20254 17390 14173 16008 18822 21838 26432 14114 17220 12064 12831 16009 12552 20564 23892 18129 12847 20315 330122 107581 14115 11852 329941 16010 407800 22339 12153 17873 13717 13601 50530 16398 58859 12814 12505 30794 18430 67252 16948 12845 21814 13807 218952 19736 22240 24051 14234 235106 234407 12836 12321 21826 18113 14219 73690 333883 23959 14089 70350 107528 20649 74488 16323 13197 67305 11803 21789 BIOCARTA_PGC1A_PATHWAY%MSIGDB_C2%BIOCARTA_PGC1A_PATHWAY BIOCARTA_PGC1A_PATHWAY 20528 26379 19057 19017 19055 19056 17260 17258 12322 108058 12323 12325 640703 215303 17261 12326 52163 15184 22629 19013 BIOCARTA_P27_PATHWAY%MSIGDB_C2%BIOCARTA_P27_PATHWAY BIOCARTA_P27_PATHWAY 22192 13555 21781 18002 54124 12447 12566 19645 27401 56438 12576 26965 21402 BIOCARTA_PTDINS_PATHWAY%MSIGDB_C2%BIOCARTA_PTDINS_PATHWAY BIOCARTA_PTDINS_PATHWAY 216238 18641 17096 56421 18762 12015 19353 271457 11651 606496 11773 18607 18803 16800 18642 11771 12229 11840 18754 56637 16449 22325 BIOCARTA_GLYCOLYSIS_PATHWAY%MSIGDB_C2%BIOCARTA_GLYCOLYSIS_PATHWAY BIOCARTA_GLYCOLYSIS_PATHWAY 13806 230163 100043349 18641 14751 21991 18770 18648 18655 15275 BIOCARTA_NUCLEARRS_PATHWAY%MSIGDB_C2%BIOCARTA_NUCLEARRS_PATHWAY BIOCARTA_NUCLEARRS_PATHWAY 76408 20186 13106 18670 18671 19401 12355 22259 19016 23957 27413 13077 19013 19015 SA_PTEN_PATHWAY%MSIGDB_C2%SA_PTEN_PATHWAY SA_PTEN_PATHWAY 19211 26417 23827 19651 228026 320495 19229 11652 23797 11651 16202 26413 18706 20416 14784 18707 20662 PID_PDGFRA_PATHWAY%MSIGDB_C2%PID_PDGFRA_PATHWAY PID_PDGFRA_PATHWAY 15978 12928 100039026 435684 12389 18708 230126 16451 20807 18595 12391 18803 14281 18706 13712 12929 107746 20416 16476 16410 14784 20662 PID_TCPTP_PATHWAY%MSIGDB_C2%PID_TCPTP_PATHWAY PID_TCPTP_PATHWAY 13645 16542 16211 16451 16453 18591 22339 100039592 56469 19246 20848 13649 16334 16412 16337 15234 20846 18596 19255 74769 20416 109700 19341 20850 20851 20662 19106 12977 18708 18710 229317 18709 20852 18706 12914 17295 14388 12978 20779 70361 14784 18707 HALLMARK_MITOTIC_SPINDLE%MSIGDB_C2%HALLMARK_MITOTIC_SPINDLE HALLMARK_MITOTIC_SPINDLE 218977 56705 30948 277360 75786 21844 18080 18817 11308 13043 227753 19765 16443 11845 242687 13383 71704 233276 208084 16328 76707 54126 216846 74018 259279 72333 16570 19877 69632 108686 17973 211673 11855 104252 16569 12488 68724 224014 219103 74470 17974 72416 16800 232533 227800 217944 213498 71774 56427 53860 17886 72776 56699 73178 16798 17318 74360 226751 18541 56376 83767 13589 114713 66406 16593 20662 110279 16561 269587 22330 94190 171207 14086 192176 71819 110380 73804 209737 276919 72119 104027 214952 70099 18003 20740 67052 22294 20878 12235 16319 104318 13822 60595 23924 77579 238130 18472 20742 23912 21973 101706 26934 11350 18015 22627 192662 56430 22145 75547 12190 24061 18005 12442 108000 19687 12534 223435 11789 17118 19303 26403 18129 12927 19158 13998 13605 74187 76932 101497 68097 74237 109934 12125 286940 270058 214444 13424 17925 104445 78757 214137 192786 232314 16906 269713 106952 18764 108903 56349 228012 68743 12345 76073 20853 12009 16897 66615 236266 70394 16579 64930 320191 208628 68041 223697 78514 237860 223254 18536 226407 226525 229841 94176 232944 218397 13006 108907 22350 110033 233406 11799 67141 240641 105988 16571 22137 217232 16551 15185 71602 16573 PID_AR_NONGENOMIC_PATHWAY%MSIGDB_C2%PID_AR_NONGENOMIC_PATHWAY PID_AR_NONGENOMIC_PATHWAY 110157 15461 14687 14681 26395 26396 75273 11651 11835 14083 26413 14281 12912 26417 14702 18708 14688 20415 14714 19353 14679 18803 18706 18797 14677 234779 18796 20779 18795 14678 PID_INTEGRIN1_PATHWAY%MSIGDB_C2%PID_INTEGRIN1_PATHWAY PID_INTEGRIN1_PATHWAY 74145 16773 226519 16772 121021 12825 22370 12834 16410 16779 12815 21923 114249 12833 14118 16780 16776 12829 12828 12475 94216 12824 16774 12830 12826 16400 12831 22339 17242 12842 16404 16398 16402 241226 16403 16412 14268 213119 12814 16775 319480 22329 12835 109700 21825 16401 16782 104099 20750 21817 12832 110135 16777 18073 14161 99571 12836 21826 140559 18793 12822 12520 67374 18792 21810 12843 PID_ER_NONGENOMIC_PATHWAY%MSIGDB_C2%PID_ER_NONGENOMIC_PATHWAY PID_ER_NONGENOMIC_PATHWAY 15461 18127 14687 14682 14681 15200 75273 268980 11651 16000 16001 17395 19094 20416 19878 18176 20662 17390 14702 18708 14688 14680 13983 17698 14675 11848 14679 13982 14672 16653 18706 14676 18797 14677 14674 18796 20779 18795 14784 12927 14678 BIOCARTA_CBL_PATHWAY%MSIGDB_C2%BIOCARTA_CBL_PATHWAY BIOCARTA_CBL_PATHWAY 13645 18750 58194 54673 227700 13649 18751 18595 17295 12402 12978 20779 14784 PID_RAC1_REG_PATHWAY%MSIGDB_C2%PID_RAC1_REG_PATHWAY PID_RAC1_REG_PATHWAY 52666 109934 53972 277360 216445 70497 21844 319899 23853 11308 219140 109904 19765 57257 24001 545156 229877 330662 13860 26934 22325 20662 54126 94176 192662 19417 19418 110279 19353 22324 223435 16800 140580 228359 73341 BIOCARTA_CHREBP2_PATHWAY%MSIGDB_C2%BIOCARTA_CHREBP2_PATHWAY BIOCARTA_CHREBP2_PATHWAY 100039786 108099 107476 22628 241113 22631 54401 19082 18749 105787 108079 269643 18747 108097 19079 22629 21770 72930 19052 71978 51792 19053 22627 14104 19088 226849 19084 19087 19085 26931 103988 110854 58805 21428 52432 235542 26932 73699 18770 225849 HALLMARK_COMPLEMENT%MSIGDB_C2%HALLMARK_COMPLEMENT HALLMARK_COMPLEMENT 22762 380921 59025 14696 72461 14067 17221 26875 14571 170638 12263 56420 18591 11808 70675 11552 11905 14127 27361 70574 19671 56697 14945 268936 72843 13660 94214 381511 19822 640703 17386 17751 67603 77613 16971 18675 14148 78287 14710 227960 18791 16889 110197 74112 63985 20909 16362 56461 18712 56193 13036 108078 17133 13039 17387 14828 229445 12827 193740 14679 11812 19072 170750 71753 13007 21417 14693 16854 17436 18706 98710 12491 16993 13482 17388 14360 11727 17394 12569 54368 14784 14479 22038 84092 12362 14939 70789 210293 16424 12759 12349 19141 12870 20202 21929 11747 18132 18815 14268 14134 16452 72269 20304 16193 16784 69181 17381 12902 66988 13032 18793 14462 16912 56212 100102 18643 18787 13030 14066 12554 11472 13040 14068 14962 12262 19164 317677 22376 16363 12369 15378 238130 21857 21947 16822 18783 18753 14058 14723 18788 11927 14061 22072 20255 12259 667277 21858 12279 330122 54123 14069 110157 320207 16621 19419 14938 12367 12371 12628 12608 20196 20703 12266 54381 16818 14702 19053 17096 13033 30955 208650 16409 333883 240672 16923 12363 50721 17002 16563 11502 20779 12258 27226 21789 14678 PID_LYSOPHOSPHOLIPID_PATHWAY%MSIGDB_C2%PID_LYSOPHOSPHOLIPID_PATHWAY PID_LYSOPHOSPHOLIPID_PATHWAY 18806 65962 18035 12928 14687 14682 19697 14681 21844 11515 11651 17395 18033 74769 11548 18753 17390 16801 18708 19353 11848 14679 14672 18803 210044 11512 14677 14674 19303 14673 56637 16476 12927 15461 19229 15200 12367 13649 14083 11513 14281 18760 16193 14702 17096 14688 22051 432530 14675 11514 104110 14676 18797 99470 53978 78134 18754 14388 104111 65086 224129 14745 20779 14678 BIOCARTA_RARRXR_PATHWAY%MSIGDB_C2%BIOCARTA_RARRXR_PATHWAY BIOCARTA_RARRXR_PATHWAY 20602 15183 98053 21374 17979 19401 17978 229906 17977 13872 18519 20181 20020 74197 83602 PID_S1P_S1P2_PATHWAY%MSIGDB_C2%PID_S1P_S1P2_PATHWAY PID_S1P_S1P2_PATHWAY 26417 14687 16367 14682 14681 26419 19353 14679 11848 14675 14739 14672 18479 26413 14281 14676 26416 13712 14677 14674 14673 12562 16476 14678 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES%MSIGDB_C2%SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES 19159 20528 93742 20663 110651 228026 16332 11652 23797 11651 240028 19065 26417 56458 22627 20112 18708 55948 606496 16370 18706 14064 56637 56513 20719 14784 18707 19211 110157 20111 100039786 16367 22628 20411 19246 22631 54401 26413 20416 16006 22629 20662 14252 12578 12331 14251 12402 384783 57261 BIOCARTA_RELA_PATHWAY%MSIGDB_C2%BIOCARTA_RELA_PATHWAY BIOCARTA_RELA_PATHWAY 21938 15183 18035 19697 22034 71609 12675 21937 14082 19766 21926 12914 18033 16150 328572 16151 PID_VEGFR1_2_PATHWAY%MSIGDB_C2%PID_VEGFR1_2_PATHWAY PID_VEGFR1_2_PATHWAY 12387 13430 29875 15516 11651 17164 19271 22370 17999 16410 18753 26417 14159 18708 19877 26397 207565 224105 17973 11848 17974 18803 18706 19303 11840 14360 14784 18750 110157 18127 14254 27371 16542 109880 12389 26395 14783 26396 19229 22339 15519 226101 11640 19082 105787 108079 18607 19247 18747 26413 14083 19079 19094 15239 103583 19255 26399 230126 16416 18751 26416 14388 12402 22330 20779 15170 12562 12385 BIOCARTA_ACTINY_PATHWAY%MSIGDB_C2%BIOCARTA_ACTINY_PATHWAY BIOCARTA_ACTINY_PATHWAY 50884 245880 69656 329165 83767 11459 17973 26444 19353 66713 56443 76709 68089 67771 18211 242687 73178 56378 74117 11867 BIOCARTA_LONGEVITY_PATHWAY%MSIGDB_C2%BIOCARTA_LONGEVITY_PATHWAY BIOCARTA_LONGEVITY_PATHWAY 15461 18708 30955 12359 56484 11651 16000 16001 667310 18706 20657 20416 20656 14600 PID_WNT_CANONICAL_PATHWAY%MSIGDB_C2%PID_WNT_CANONICAL_PATHWAY PID_WNT_CANONICAL_PATHWAY 240756 84095 214897 12387 71810 12389 13544 18719 72293 226849 16974 606496 13543 26554 22416 11789 14367 13542 12005 56637 SA_B_CELL_RECEPTOR_COMPLEXES%MSIGDB_C2%SA_B_CELL_RECEPTOR_COMPLEXES SA_B_CELL_RECEPTOR_COMPLEXES 26417 15461 20963 20111 17096 110651 17060 26395 26401 110279 19353 22324 18491 11909 57257 26413 14281 13712 30957 20416 16476 14784 22325 20662 PID_INTEGRIN_A9B1_PATHWAY%MSIGDB_C2%PID_INTEGRIN_A9B1_PATHWAY PID_INTEGRIN_A9B1_PATHWAY 74145 212503 22339 11489 11490 18126 16412 14268 12981 22329 104099 11495 21817 20750 12982 11501 21923 16516 22341 14205 19353 20229 19303 20779 12927 BIOCARTA_SET_PATHWAY%MSIGDB_C2%BIOCARTA_SET_PATHWAY BIOCARTA_SET_PATHWAY 13368 13347 14939 12914 18646 97165 14938 671392 18102 11792 11737 PID_PI3KCI_PATHWAY%MSIGDB_C2%PID_PI3KCI_PATHWAY PID_PI3KCI_PATHWAY 19159 12143 22612 16332 11845 74769 19157 20963 18708 18710 18709 19353 11848 18803 18706 16428 14360 11840 18707 19158 19211 320207 15461 106952 15519 56484 16331 18607 20393 18176 16818 22637 26377 104709 231821 11844 17096 16797 30955 17060 83436 101476 16653 14191 15162 234779 12229 109905 20779 BIOCARTA_ASBCELL_PATHWAY%MSIGDB_C2%BIOCARTA_ASBCELL_PATHWAY BIOCARTA_ASBCELL_PATHWAY 14103 12487 16183 14968 12519 14969 14102 21939 12504 16153 21947 16189 NABA_ECM_AFFILIATED%MSIGDB_C2%NABA_ECM_AFFILIATED NABA_ECM_AFFILIATED 14733 26888 26359 140570 20969 20390 16852 20971 16854 14734 17195 71693 12306 239447 232414 11747 56644 69787 207393 243312 14735 29873 20970 140792 14134 59308 216551 16429 71951 333315 242022 329872 17063 235416 56072 107753 16855 23888 103978 15458 353328 140474 12659 269328 73732 100039649 23845 16859 56048 20354 18844 11744 72324 15529 67448 243743 16858 231440 18845 18846 20347 56745 69183 23829 226359 11752 70361 11749 11745 11750 20387 170786 224116 121021 12262 18489 140571 54712 67784 67709 20346 19693 19695 108151 20349 20350 218877 20356 20352 20351 20353 20357 20355 26456 20360 214968 20358 20359 20388 20361 20389 20348 56620 170779 75863 51811 56619 17474 12259 21922 381809 12260 665180 403395 243653 56760 71183 353287 20256 66864 17312 23892 232413 109323 239126 227580 239659 17829 16952 71790 19692 235611 11746 PID_WNT_SIGNALING_PATHWAY%MSIGDB_C2%PID_WNT_SIGNALING_PATHWAY PID_WNT_SIGNALING_PATHWAY 16010 73016 14370 14367 14369 13380 22413 24117 14371 20187 84035 68588 70495 93897 16974 16973 192199 22408 22416 26564 14366 22415 14368 14362 22421 22418 57265 22422 PID_RETINOIC_ACID_PATHWAY%MSIGDB_C2%PID_RETINOIC_ACID_PATHWAY PID_RETINOIC_ACID_PATHWAY 18750 15183 20183 26419 19401 12572 11651 218772 18747 26413 19411 18519 433759 17420 66671 20182 26417 20602 17979 22337 17978 19659 17977 12534 26416 268903 12914 20181 18752 328572 NABA_MATRISOME%MSIGDB_C2%NABA_MATRISOME NABA_MATRISOME 18591 20969 20971 18451 12032 14734 12306 18654 12111 13004 14735 20970 21817 16193 16176 16191 20292 23845 112406 20354 15529 16322 20198 22403 57875 18787 18792 21810 51795 16189 14560 14561 14562 14563 229574 14256 21803 14168 83554 387510 230405 668304 14181 14174 72514 14176 14178 71920 81701 353156 54156 54394 381457 100042150 12919 14167 14166 14165 56636 80857 14169 13607 20311 215257 58181 257630 140806 54450 54448 93672 69677 17700 18188 319909 27356 269878 230971 230316 18119 14566 78405 12064 238057 239114 215274 56069 234836 16325 16324 329244 16336 67933 242316 76527 15161 13645 326623 50930 216505 240873 54612 20319 71325 99681 268686 12309 268935 64706 22423 22412 20203 109910 214058 320202 217738 13590 20197 20200 20199 70417 20194 20196 67860 66166 19197 57349 20193 20129 16948 320460 16963 278507 235611 215001 22164 22410 319922 22018 16323 12165 16156 26888 26359 20377 20890 22413 20379 22409 22411 22341 14205 20296 14825 16852 11705 21949 11839 13363 16147 15245 22416 22417 22414 22415 22420 22421 22418 22419 216795 22422 20201 14164 14172 64654 16002 22340 15235 20378 13019 14314 15200 21802 20312 17242 20202 23886 14170 14177 14179 16181 14171 14180 12160 12154 19242 20295 116849 21944 13874 26360 20304 12223 12404 215378 56410 12405 12163 20297 240843 24117 110075 12155 83430 83961 70726 72713 11876 654812 12803 69121 20299 21832 12931 57266 18183 56708 228942 20290 100039973 100038965 56221 56838 20302 320924 13040 19073 11746 230398 16171 16170 16153 16163 16168 16198 16992 210530 11495 14789 16716 12829 12828 94216 12830 12826 12827 18590 16854 13011 13012 15160 20723 73720 76770 112407 58214 319433 20720 74468 20568 20725 116872 18816 20317 20195 240725 68054 11747 380780 69787 331535 12406 67931 72043 19143 66222 71907 20248 394252 268591 20716 66957 241197 14175 16949 11501 16950 94352 67573 209378 107250 56401 109685 77042 16425 215015 80752 226243 545291 78558 13032 13041 228756 19025 330723 56464 15587 15586 20347 13013 13003 13014 67868 71756 78240 13010 64138 16007 208659 11487 74145 14068 15442 12401 240322 216725 223838 330119 110595 21892 21818 331046 74176 241636 13522 20713 208936 271127 235505 215095 13706 54426 69066 30806 109901 108154 240913 224697 108153 279028 239337 235130 237360 14058 26433 19142 18822 26432 58223 23948 22072 17389 320452 20300 74443 20348 241196 71869 30924 18552 14114 18553 210622 23850 24087 18491 270086 66627 21858 640543 19146 17288 26561 17391 30800 214766 20719 234911 118453 240047 17829 16010 71790 11488 11496 11492 13524 58860 11500 71078 244486 110751 353188 13033 11699 66548 229595 269959 77794 77739 19109 12822 20724 56622 24099 69583 18413 15945 20310 50498 20293 12977 16196 56066 20306 56744 232345 16424 94175 16427 17195 12981 16006 12161 12156 12162 20387 12159 20423 21857 18049 12667 23892 14313 330122 17329 16326 16994 243369 54635 55985 19699 16000 16334 21943 18791 20390 17311 14071 50701 12843 224116 121021 22035 18489 140571 54712 67784 67709 20346 19693 19695 108151 20349 20350 218877 20356 20352 20351 20353 20357 20355 26456 20360 214968 20358 20359 20388 20361 20389 56620 170779 75863 51811 56619 17474 21922 381809 665180 403395 243653 56760 22408 71183 353287 20256 66864 17312 232413 109323 239126 227580 239659 58992 16952 22339 385643 12153 15977 19692 17393 20703 21926 12985 16175 11502 12258 16426 93735 11504 21816 217847 17384 17385 17175 56213 17287 13036 13038 12824 13039 17387 14060 229445 17388 17394 21859 23794 23792 59007 16858 70361 170786 11490 11698 16008 21808 18788 67112 80903 23919 18205 14573 20315 11606 16160 16173 16159 15978 13034 16773 620395 14733 20563 20692 16772 11905 11489 12825 11603 140570 11568 12834 12819 29817 16774 83995 16878 13179 17313 12842 12835 67776 71768 328643 70853 69882 192199 18452 232585 27762 13030 239852 22787 22788 75718 18133 226519 22786 22371 80883 243967 57764 18209 170721 229389 18419 18302 50706 69675 18542 76477 17182 17181 17180 108075 216760 100034361 94111 17183 105450 338352 70945 76293 18074 68169 207596 54003 21827 26944 329278 21828 94242 21960 252974 21930 81877 22283 240675 244152 233813 74199 246228 226866 228770 72780 239405 208777 64074 64075 20564 233744 13602 21684 21683 64817 140703 107581 14115 329941 280635 12837 17304 68792 12840 407800 12821 216616 12841 100952 246707 13717 13601 12817 50530 12813 56429 12945 268780 58859 12814 16775 236790 382864 83691 78892 666279 50766 214425 16777 18073 68709 171508 12845 242603 76737 330470 73230 16997 16998 11704 12810 12836 21826 246316 56839 333088 242050 268977 76905 243914 213469 665700 14456 235379 78919 75426 16012 16011 16005 224224 63859 15530 330790 67666 73940 14264 13406 242608 244550 27047 269120 236690 18295 16545 17022 70370 72902 94214 71785 20745 53856 19074 17386 100689 22370 116847 17395 231470 68655 15234 320181 234199 14190 14119 17150 23876 16779 12815 21923 114249 12833 14118 16780 16776 20303 12818 12839 77018 140709 20562 68588 12823 12816 11450 237759 245026 53867 213945 373864 69700 73368 13516 71690 71355 12950 66695 320712 12643 19387 71693 239447 11600 232414 56644 18815 207393 22402 243312 29873 14268 140792 15891 14134 13612 59308 18208 216551 23928 16429 21825 71951 16782 333315 20750 11602 242022 12832 329872 110135 17063 235416 56072 14161 107753 99571 16855 23888 103978 15458 13035 353328 140474 12659 17381 269328 17392 73732 100039649 16859 56048 18844 11744 72324 67448 243743 231440 18845 18846 56745 69183 23829 226359 11752 11749 11745 11750 12262 11491 17390 14173 11601 14061 12259 211323 12260 12831 16009 14103 16183 16846 21809 14219 13856 BIOCARTA_IL17_PATHWAY%MSIGDB_C2%BIOCARTA_IL17_PATHWAY BIOCARTA_IL17_PATHWAY 16193 17311 12490 12985 12500 16171 12501 12504 12502 12503 12525 12481 BIOCARTA_IL7_PATHWAY%MSIGDB_C2%BIOCARTA_IL7_PATHWAY BIOCARTA_IL7_PATHWAY 16818 12043 16196 18708 16451 16453 30955 19229 16186 16197 64685 18706 12914 14360 328572 20850 20851 BIOCARTA_NO2IL12_PATHWAY%MSIGDB_C2%BIOCARTA_NO2IL12_PATHWAY BIOCARTA_NO2IL12_PATHWAY 16162 15978 16161 12766 20849 12504 12481 18126 12774 12500 16452 12501 12502 16160 12503 16159 54721 BIOCARTA_ATM_PATHWAY%MSIGDB_C2%BIOCARTA_ATM_PATHWAY BIOCARTA_ATM_PATHWAY 18035 12649 225182 19361 19697 26419 27354 11920 19360 22062 17246 17535 22059 50883 12575 18033 13197 12189 16476 11350 BIOCARTA_NKT_PATHWAY%MSIGDB_C2%BIOCARTA_NKT_PATHWAY BIOCARTA_NKT_PATHWAY 12768 16183 15979 21803 15980 12774 12981 21947 16160 16159 16162 12772 15978 12773 16161 21808 16191 12487 12766 21809 12771 16182 20303 12504 16190 12775 12767 16189 PID_THROMBIN_PAR4_PATHWAY%MSIGDB_C2%PID_THROMBIN_PAR4_PATHWAY PID_THROMBIN_PAR4_PATHWAY 14702 14061 14688 14682 19877 14065 17906 11848 14675 14672 14676 14064 14674 18796 19878 BIOCARTA_MCM_PATHWAY%MSIGDB_C2%BIOCARTA_MCM_PATHWAY BIOCARTA_MCM_PATHWAY 17311 17218 18392 17217 17219 12447 17215 12566 26428 23834 26429 67177 50793 17220 56452 12576 17216 18393 BIOCARTA_MITOCHONDRIA_PATHWAY%MSIGDB_C2%BIOCARTA_MITOCHONDRIA_PATHWAY BIOCARTA_MITOCHONDRIA_PATHWAY 13368 13347 12368 11797 12043 12124 26926 12122 12028 11798 670717 66593 12370 12048 12367 12371 13804 11783 12369 11796 12018 HALLMARK_MYC_TARGETS_V2%MSIGDB_C2%HALLMARK_MYC_TARGETS_V2 HALLMARK_MYC_TARGETS_V2 18148 22256 76130 66590 71974 18817 70683 27993 338359 66164 53414 13537 53608 20322 231872 17218 27998 12417 12567 628438 21453 235036 30877 107071 226169 64934 18813 28126 69902 75751 18673 20873 15278 100608 68493 227746 72515 67973 101612 66422 21379 15510 17217 66942 20509 18432 15277 67134 69071 27966 107094 20810 70769 59028 110109 56361 13340 17869 HALLMARK_P53_PATHWAY%MSIGDB_C2%HALLMARK_P53_PATHWAY HALLMARK_P53_PATHWAY 57913 71712 11820 76884 75234 20620 17347 102626 140570 15939 21987 13198 19367 22591 20969 16878 15368 18590 192897 20181 19730 13830 224624 16832 319162 105501 70925 228775 21452 170742 53421 216049 70930 11910 192231 15254 71839 12445 14667 19645 101867 98845 670832 622534 13139 68558 17254 101565 22592 114714 19143 100039683 56312 17988 22401 27280 12444 76500 11486 13663 59002 232440 107939 68098 12450 80905 26570 107986 11636 67776 12578 20683 20198 11783 12520 56464 15937 12606 12575 16600 12554 242585 13849 19734 21803 14168 53892 67442 67880 27416 108100 22032 16324 68048 229933 21952 18538 99681 12703 22320 20194 22271 29858 66383 19899 12521 12226 13033 70186 16175 20724 13197 16179 259277 67426 20698 71665 74012 230233 17122 235320 12192 12227 16667 18415 12569 16476 13836 12795 12362 11688 18081 15200 21802 56338 56484 16450 14281 14102 231712 16554 20229 21807 14149 12156 65972 18128 19124 107568 19267 21354 68428 18072 16970 216456 12454 52808 15468 17112 53619 67941 50708 140742 99480 68755 22337 207785 14694 217344 55948 214254 69786 71795 67623 50754 19250 64058 22061 56437 69076 14776 74747 17119 15461 15183 14062 12028 23853 268860 19079 22057 12018 11479 12579 17872 116914 17246 22059 BIOCARTA_PARKIN_PATHWAY%MSIGDB_C2%BIOCARTA_PARKIN_PATHWAY BIOCARTA_PARKIN_PATHWAY 67921 14763 56791 218793 22213 67128 18951 20617 22195 67847 50873 BIOCARTA_ATRBRCA_PATHWAY%MSIGDB_C2%BIOCARTA_ATRBRCA_PATHWAY BIOCARTA_ATRBRCA_PATHWAY 60534 19367 22040 72775 19356 12649 19361 12190 211651 15574 27354 14088 11920 19360 17535 22059 50883 100040608 12189 19355 ST_G_ALPHA_I_PATHWAY%MSIGDB_C2%ST_G_ALPHA_I_PATHWAY ST_G_ALPHA_I_PATHWAY 16439 110157 228550 109880 20663 14962 11652 16438 23797 11651 20848 13649 26413 16440 320404 74769 20416 58175 20662 18798 13138 13844 13489 11886 16521 16524 57321 18741 16519 18797 18796 20779 18795 14784 BIOCARTA_EPO_PATHWAY%MSIGDB_C2%BIOCARTA_EPO_PATHWAY BIOCARTA_EPO_PATHWAY 26417 110157 15461 100039026 26395 26419 18803 14281 13712 16452 20416 13857 20850 16476 15170 20851 14784 13856 20662 BIOCARTA_IGF1_PATHWAY%MSIGDB_C2%BIOCARTA_IGF1_PATHWAY BIOCARTA_IGF1_PATHWAY 26417 110157 15461 218397 100039026 16367 18708 30955 26395 26419 16000 20807 16001 19247 14281 18706 13712 20416 16476 14784 20662 BIOCARTA_EIF2_PATHWAY%MSIGDB_C2%BIOCARTA_EIF2_PATHWAY BIOCARTA_EIF2_PATHWAY 13665 13666 217869 67204 26905 15467 19045 56637 27103 224045 19106 PID_IL2_STAT5_PATHWAY%MSIGDB_C2%PID_IL2_STAT5_PATHWAY PID_IL2_STAT5_PATHWAY 16184 12043 14103 16183 18646 16451 16453 12445 12048 16992 14389 19247 20416 13709 12444 20371 20850 20851 20662 16818 18708 16186 16185 20683 18706 17869 12571 14784 12428 16189 PID_PLK1_PATHWAY%MSIGDB_C2%PID_PLK1_PATHWAY PID_PLK1_PATHWAY 13605 56371 218294 19348 18817 243369 72119 67052 20878 20843 12235 77744 16319 99412 236930 18479 67629 12236 72415 78177 269582 71876 103583 100043703 74498 103733 228730 19046 19878 19052 229841 51792 17931 233406 67141 107995 11848 12534 16563 12531 18221 19324 12532 22390 BIOCARTA_CARM_ER_PATHWAY%MSIGDB_C2%BIOCARTA_CARM_ER_PATHWAY BIOCARTA_CARM_ER_PATHWAY 15183 12034 98053 59035 75273 19017 17260 15077 79221 433759 15184 20602 21374 74053 19014 208727 56381 13872 13982 24068 170787 11614 268903 12914 70315 232232 15182 20020 15185 12189 56233 328572 12443 74197 83602 BIOCARTA_INFLAM_PATHWAY%MSIGDB_C2%BIOCARTA_INFLAM_PATHWAY BIOCARTA_INFLAM_PATHWAY 16183 21803 230398 16153 16163 16168 16992 15977 12981 16160 16159 16193 15978 21808 16191 14968 12977 21809 16196 14969 12504 21926 18590 12985 16175 16156 16189 BIOCARTA_IL3_PATHWAY%MSIGDB_C2%BIOCARTA_IL3_PATHWAY BIOCARTA_IL3_PATHWAY 110157 26417 15461 26395 14281 16188 12984 16452 20416 15170 20850 20851 14784 20662 PID_NETRIN_PATHWAY%MSIGDB_C2%PID_NETRIN_PATHWAY PID_NETRIN_PATHWAY 17755 13176 22612 26395 26396 12322 18479 14083 26413 330662 69635 18208 26417 22253 107448 18708 216439 17973 19353 11848 223435 18803 140580 18706 107449 18738 14360 17909 73178 20779 12927 BIOCARTA_PROTEASOME_PATHWAY%MSIGDB_C2%BIOCARTA_PROTEASOME_PATHWAY BIOCARTA_PROTEASOME_PATHWAY 23996 26441 67089 19166 22215 26443 26444 19167 26446 57296 103963 26440 19182 59029 20014 19170 19181 22201 66997 66413 19173 19172 69077 19177 19175 22209 26442 26445 BIOCARTA_LECTIN_PATHWAY%MSIGDB_C2%BIOCARTA_LECTIN_PATHWAY BIOCARTA_LECTIN_PATHWAY 230558 17175 12279 12263 12266 109828 12274 15139 625018 17195 BIOCARTA_HCMV_PATHWAY%MSIGDB_C2%BIOCARTA_HCMV_PATHWAY BIOCARTA_HCMV_PATHWAY 26417 26399 18708 30955 19697 26395 26401 26396 26397 19645 11651 20683 26413 18706 26416 12912 18033 BIOCARTA_ECM_PATHWAY%MSIGDB_C2%BIOCARTA_ECM_PATHWAY BIOCARTA_ECM_PATHWAY 26417 110157 15461 18708 21894 19877 30955 107589 26395 11855 227753 17906 11848 14083 26413 18706 16412 18643 19303 14360 109700 20416 20779 13367 HALLMARK_UV_RESPONSE_DN%MSIGDB_C2%HALLMARK_UV_RESPONSE_DN HALLMARK_UV_RESPONSE_DN 67916 17250 17127 234515 14200 12825 231070 17748 16001 545156 20893 18596 22359 19220 23938 13866 23945 18858 13383 22325 23876 11541 18710 236915 14609 19016 21788 12576 17295 21872 20181 14360 328365 17684 18707 226751 30953 56376 218038 229615 67972 57810 12306 12842 114713 20583 12832 20238 16416 18400 15529 16590 24000 59125 18787 14066 56273 16835 12843 16007 17314 14773 15117 226519 12166 23797 13548 14537 235574 18033 13132 18798 18186 11987 17389 12064 20975 18129 57312 18750 19211 50791 14007 109552 50768 69219 20273 17755 16367 13170 12389 11787 68055 54650 207615 216616 12286 213109 64009 11480 16531 69562 19252 22589 12814 231386 12040 210106 67252 21813 21814 116870 19088 19736 353187 11990 381290 14815 17131 328108 27360 110593 74194 268977 99633 252875 26416 71175 15901 18754 19274 14745 17869 217692 15893 16011 57265 20747 11746 66549 BIOCARTA_TGFB_PATHWAY%MSIGDB_C2%BIOCARTA_TGFB_PATHWAY BIOCARTA_TGFB_PATHWAY 26417 17128 21808 21812 21813 21809 12550 21803 26395 20482 17127 230597 26409 17131 17126 11789 12914 66513 328572 BIOCARTA_AGR_PATHWAY%MSIGDB_C2%BIOCARTA_AGR_PATHWAY BIOCARTA_AGR_PATHWAY 11435 13405 18198 16773 22288 26419 13043 70584 18481 12669 214230 241656 13649 18479 26413 14083 16412 100042150 16775 109700 19400 13138 26417 11459 16774 224105 19353 211323 20683 26431 18183 13542 19303 20779 16476 BIOCARTA_GATA3_PATHWAY%MSIGDB_C2%BIOCARTA_GATA3_PATHWAY BIOCARTA_GATA3_PATHWAY 18019 18018 16191 16477 19088 26397 19084 16163 19087 19085 18749 14462 17132 26416 16189 PID_P38_MKK3_6PATHWAY%MSIGDB_C2%PID_P38_MKK3_6PATHWAY PID_P38_MKK3_6PATHWAY 22166 22030 26401 22034 17873 23882 26406 26409 26408 12323 19094 53608 26407 269881 216965 330177 26399 26397 19353 11920 26416 66513 68652 13197 216527 ST_WNT_BETA_CATENIN_PATHWAY%MSIGDB_C2%ST_WNT_BETA_CATENIN_PATHWAY ST_WNT_BETA_CATENIN_PATHWAY 12387 12006 14314 11652 19262 56811 23797 11651 19164 93687 93960 78388 319478 16971 50781 59036 75826 73739 140577 22094 16785 20377 13380 72293 24117 234130 14296 23988 606496 12622 11789 13542 12005 56637 PID_ENDOTHELIN_PATHWAY%MSIGDB_C2%PID_ENDOTHELIN_PATHWAY PID_ENDOTHELIN_PATHWAY 12928 14687 14682 14681 26419 11515 12825 11651 13618 13617 13614 18783 18753 26417 14680 83995 19353 11848 14679 14672 210044 14677 11512 22068 14673 13615 16476 12927 18750 110157 15461 26395 26396 19229 70086 58861 13616 26413 11513 14281 16452 105243 20544 432530 14675 18751 11514 104110 14676 18797 26416 18796 18754 104111 18752 224129 18761 18795 20779 18755 12843 14678 PID_IL4_2PATHWAY%MSIGDB_C2%PID_IL4_2PATHWAY PID_IL4_2PATHWAY 13654 16451 16453 16153 18703 11651 16992 21947 16364 23871 21838 13449 56468 14159 18708 18706 14784 11687 17863 21786 16367 17864 12703 12048 16164 12842 245195 547253 16331 12608 11628 14128 11846 18390 66596 20295 16452 56717 20416 20850 20851 16191 20292 16190 16165 20852 16186 16416 15361 20683 12702 26416 12053 12402 384783 20344 20375 15170 12843 16189 NABA_BASEMENT_MEMBRANES%MSIGDB_C2%NABA_BASEMENT_MEMBRANES NABA_BASEMENT_MEMBRANES 15530 16773 226519 80883 16772 243967 57764 18209 170721 11603 12834 16775 18208 12835 382864 12819 23928 16782 16779 18074 16777 18073 114249 12833 16780 16776 12829 12828 94216 16774 12830 22283 12826 12827 245026 12822 665700 PID_SYNDECAN_4_PATHWAY%MSIGDB_C2%PID_SYNDECAN_4_PATHWAY PID_SYNDECAN_4_PATHWAY 18750 14182 57916 13430 16772 11489 17242 14177 18815 14083 16402 16412 14268 17395 53378 21825 18753 14369 20304 14173 21923 14061 66911 16774 19353 20971 11848 21788 109711 67903 12767 20315 ST_STAT3_PATHWAY%MSIGDB_C2%ST_STAT3_PATHWAY ST_STAT3_PATHWAY 16193 20848 19273 19692 16194 16451 16452 16453 229615 12700 20779 BIOCARTA_P53_PATHWAY%MSIGDB_C2%BIOCARTA_P53_PATHWAY BIOCARTA_P53_PATHWAY 13555 12043 12028 18538 12447 12566 12567 19645 11920 11783 17246 22059 12575 13197 21859 12443 PID_P75_NTR_PATHWAY%MSIGDB_C2%PID_P75_NTR_PATHWAY PID_P75_NTR_PATHWAY 208117 26419 11820 22034 66593 12675 11651 19164 11491 72843 18049 18211 16151 17136 68585 12070 13555 18377 192662 22627 20661 26420 65079 18708 17984 26414 19716 670717 18762 18053 66647 12015 192656 75625 19353 235402 17874 170936 11848 78405 18550 12064 18205 18759 18706 16150 12368 11797 11852 12125 18412 12367 12371 18749 100039623 20598 59287 100042305 18815 11853 17393 20416 94275 11798 17392 11783 11796 22059 16179 ST_INTERLEUKIN_4_PATHWAY%MSIGDB_C2%ST_INTERLEUKIN_4_PATHWAY ST_INTERLEUKIN_4_PATHWAY 20663 16451 16190 16453 20852 16186 21981 11652 16164 23797 11651 16331 18706 23957 16452 20416 20779 12700 14784 16189 105148 54721 20662 BIOCARTA_ERK_PATHWAY%MSIGDB_C2%BIOCARTA_ERK_PATHWAY BIOCARTA_ERK_PATHWAY 110157 15461 20111 26395 26396 17347 13649 20848 17346 16001 26413 16412 13712 18049 20416 20662 19052 26417 14688 18053 18595 14699 73086 19279 20779 17869 14784 BIOCARTA_DEATH_PATHWAY%MSIGDB_C2%BIOCARTA_DEATH_PATHWAY BIOCARTA_DEATH_PATHWAY 53859 13368 13347 12368 12043 11797 12122 18035 22030 19697 14453 12370 71609 12367 12633 12675 20740 22035 12371 12369 18033 21944 85030 11798 670717 16905 14082 19766 21933 11783 11796 BIOCARTA_HER2_PATHWAY%MSIGDB_C2%BIOCARTA_HER2_PATHWAY BIOCARTA_HER2_PATHWAY 16193 26417 110157 15461 18708 74053 13869 30955 26395 59035 13867 20848 13649 13982 16195 26413 18706 16194 20416 328572 14784 20662 WNT_SIGNALING%MSIGDB_C2%WNT_SIGNALING WNT_SIGNALING 11461 12387 100039026 93735 21415 13016 93687 104318 12234 14283 20377 20890 22413 20379 22409 22411 12010 14365 14296 53627 22121 606496 69581 72135 20671 20997 30050 16842 15218 22416 330938 22408 11789 22417 18741 13017 22414 13542 12005 22415 14362 22420 22421 56637 30838 22418 22419 16476 216795 22422 18099 20378 15452 12445 22402 93960 14370 319478 14367 103583 208846 75826 12444 14369 14175 19052 13380 21885 26941 51792 67087 214897 14797 14308 77578 24117 21886 21414 84035 16974 100043349 13543 16973 14366 14368 17869 328572 12443 57265 PID_HIF1A_PATHWAY%MSIGDB_C2%PID_HIF1A_PATHWAY PID_HIF1A_PATHWAY 15251 67923 319594 22346 11863 112407 14694 15519 112406 12578 56438 53417 26754 22059 216440 56292 71745 PID_NECTIN_PATHWAY%MSIGDB_C2%PID_NECTIN_PATHWAY PID_NECTIN_PATHWAY 12387 12928 12550 21894 18717 29875 18591 227377 17356 14083 58998 58235 18596 16410 22325 16456 18708 19353 16416 18706 107746 12737 109905 19274 20779 215449 19294 12385 BIOCARTA_ERYTH_PATHWAY%MSIGDB_C2%BIOCARTA_ERYTH_PATHWAY BIOCARTA_ERYTH_PATHWAY 17311 16193 21808 21809 21803 16198 16000 12985 16175 12981 14255 16156 13856 BIOCARTA_BCR_PATHWAY%MSIGDB_C2%BIOCARTA_BCR_PATHWAY BIOCARTA_BCR_PATHWAY 18750 110157 15461 26401 26395 26419 640703 14281 13712 20416 20662 26417 18019 20963 18018 17096 73181 19057 17060 19055 19056 19353 22324 18021 18751 18803 26416 12518 12229 15985 16476 14784 HALLMARK_PROTEIN_SECRETION%MSIGDB_C2%HALLMARK_PROTEIN_SECRETION HALLMARK_PROTEIN_SECRETION 74006 100042773 11487 16651 213827 59042 68365 11303 110935 70349 12068 100042343 67074 67830 110651 53330 20333 50797 53331 228960 22365 69608 211286 76332 77929 11977 17113 54214 14420 72736 11765 208449 107767 108123 108124 69162 66366 24045 20844 20955 19334 71770 108664 11774 26951 11928 99371 66251 18484 11777 67804 211673 11773 56041 56494 67300 11840 320634 100042570 22088 107338 12757 16004 20479 16668 19063 13649 26413 56418 232910 22319 216350 69938 20404 99889 66471 100226 20619 71943 12512 12725 16784 271457 16561 13032 11605 12390 667310 56382 59021 70361 15893 BIOCARTA_DNAFRAGMENT_PATHWAY%MSIGDB_C2%BIOCARTA_DNAFRAGMENT_PATHWAY BIOCARTA_DNAFRAGMENT_PATHWAY 13368 13347 13804 12369 14939 21974 97165 434174 21973 12367 BIOCARTA_IL6_PATHWAY%MSIGDB_C2%BIOCARTA_IL6_PATHWAY BIOCARTA_IL6_PATHWAY 16193 26417 110157 15461 100039026 16451 26395 16453 20848 20807 16195 12608 19247 14281 13712 16194 16452 20416 16476 14784 54721 20662 PID_RANBP2_PATHWAY%MSIGDB_C2%PID_RANBP2_PATHWAY PID_RANBP2_PATHWAY 17344 19386 17246 19384 103573 433759 56469 208727 22196 PID_ATM_PATHWAY%MSIGDB_C2%PID_ATM_PATHWAY PID_ATM_PATHWAY 12122 93765 225182 12144 54401 13016 27354 26374 21975 19360 21849 11350 19367 19356 13006 70681 211651 240087 24061 20184 27223 12530 81601 11920 15270 21750 17246 17535 50883 108138 12189 12532 227525 BIOCARTA_TCAPOPTOSIS_PATHWAY%MSIGDB_C2%BIOCARTA_TCAPOPTOSIS_PATHWAY BIOCARTA_TCAPOPTOSIS_PATHWAY 14103 12774 12487 12500 14102 12501 12504 12502 12503 PID_EPHA2_FWD_PATHWAY%MSIGDB_C2%PID_EPHA2_FWD_PATHWAY PID_EPHA2_FWD_PATHWAY 232906 18708 21844 16332 19353 11848 18479 14083 57257 18706 11431 12402 13636 20416 20779 14784 22325 13836 12927 BIOCARTA_NFKB_PATHWAY%MSIGDB_C2%BIOCARTA_NFKB_PATHWAY BIOCARTA_NFKB_PATHWAY 53859 21938 18035 16177 26401 19697 22034 71609 12675 17874 21937 14082 26409 21929 21898 19766 21926 16175 66513 18033 16150 16179 16151 HALLMARK_TGF_BETA_SIGNALING%MSIGDB_C2%HALLMARK_TGF_BETA_SIGNALING HALLMARK_TGF_BETA_SIGNALING 12156 12387 12168 17130 21803 12550 20515 66105 12166 17127 21815 20742 14225 97064 20482 11848 13805 18550 11477 11789 18121 21872 19042 17125 12577 16477 106572 15980 20481 21847 320202 26409 433759 21825 65112 20602 21812 15258 11798 17872 16997 15902 19045 94093 66313 107951 15903 94246 14272 29815 75788 17131 18787 15901 PID_RET_PATHWAY%MSIGDB_C2%PID_RET_PATHWAY PID_RET_PATHWAY 18750 15461 12928 16367 14783 14585 26419 19713 19247 18747 14083 26413 12912 20416 20662 26417 327826 218397 18708 17973 14786 19353 11848 13448 58234 623279 76829 114255 18706 14573 19303 109905 14388 384783 20779 16476 14784 12927 BIOCARTA_AMI_PATHWAY%MSIGDB_C2%BIOCARTA_AMI_PATHWAY BIOCARTA_AMI_PATHWAY 110135 14068 14161 19123 14062 99571 14061 12829 12828 94216 11905 12830 12826 12827 18815 21788 19128 18791 14058 HALLMARK_MTORC1_SIGNALING%MSIGDB_C2%HALLMARK_MTORC1_SIGNALING HALLMARK_MTORC1_SIGNALING 68278 170439 18817 68275 20893 20855 13198 67204 14385 110391 14828 12449 18030 17436 21753 104112 56480 18451 17216 13806 23996 67089 18641 16828 14751 228775 15510 63913 17217 18412 112407 22042 100040592 19141 27053 13361 20525 15277 15288 13121 12406 12527 15982 56312 26754 69071 27966 170459 14629 56473 15357 229363 21399 235293 11674 13595 12450 73166 50493 26570 14381 13360 13032 100043349 20527 12575 20249 18655 16835 26441 20878 12235 14782 225363 18107 59029 268373 68801 26432 22145 20867 12035 26397 66427 12330 628438 107508 56041 12530 59027 231887 56637 20514 18950 22433 103963 20539 56418 26377 26941 74185 50527 635960 16414 16011 20775 72157 21991 107869 231070 17113 68465 74205 20322 22359 14190 18710 12227 15525 16993 100041835 27407 12466 21366 74754 74192 12721 15926 67895 56207 100678 23997 67486 15452 19192 67890 76267 12301 66249 236539 70699 73834 53333 11938 108037 18477 319554 56305 14149 83671 27275 665563 19324 17252 78925 14227 64136 66143 56772 74105 20491 18036 22256 22375 14884 228026 66105 17768 19167 28146 20135 65972 12317 107513 103733 22027 192193 18636 54353 107272 93692 56529 15526 74747 12767 18046 56088 107476 19181 66997 76614 19173 17872 19769 55963 14718 11605 66713 27360 74117 BIOCARTA_STRESS_PATHWAY%MSIGDB_C2%BIOCARTA_STRESS_PATHWAY BIOCARTA_STRESS_PATHWAY 53859 18035 22030 19697 26401 26419 26412 71609 12675 12905 16992 100040260 18033 16151 26399 26397 21937 19766 12366 26398 21926 21353 26416 16150 16476 PID_HDAC_CLASSII_PATHWAY%MSIGDB_C2%PID_HDAC_CLASSII_PATHWAY PID_HDAC_CLASSII_PATHWAY 22151 15183 110355 19384 15519 17260 54401 20807 71458 68558 19727 14460 12326 79221 103573 15184 20602 14702 22627 14688 208727 13982 19386 14815 22143 170787 14461 12053 232232 15185 56233 22196 PID_ALK1_PATHWAY%MSIGDB_C2%PID_ALK1_PATHWAY PID_ALK1_PATHWAY 12168 21803 12389 11480 11481 26413 13001 14225 26417 11482 17128 21812 21813 21809 19045 216869 13805 17131 21909 11477 16323 12165 15901 17129 55994 17125 BIOCARTA_INSULIN_PATHWAY%MSIGDB_C2%BIOCARTA_INSULIN_PATHWAY BIOCARTA_INSULIN_PATHWAY 26417 110157 15461 20528 218397 100039026 16367 18708 30955 26395 26419 20807 16334 19247 14281 16337 18706 13712 20416 16476 14784 20662 NABA_PROTEOGLYCANS%MSIGDB_C2%NABA_PROTEOGLYCANS NABA_PROTEOGLYCANS 224224 63859 15530 330790 67666 73940 12032 14264 242608 244550 27047 269120 236690 18295 16545 17022 72902 94214 12111 20745 13004 53856 19074 116847 19073 13179 13516 13003 71690 12950 66695 12643 19387 PID_AR_TF_PATHWAY%MSIGDB_C2%PID_AR_TF_PATHWAY PID_AR_TF_PATHWAY 20183 59035 26419 20588 22026 11835 19696 30051 20182 56458 14694 26398 50528 20181 56637 16476 320795 22025 18986 15519 52915 217127 15502 18585 223870 15408 21848 18519 110147 433759 57376 67155 26399 68098 13653 17978 17977 14815 66884 81601 93759 14461 11614 12914 26416 17246 12606 20779 328572 56233 BIOCARTA_UCALPAIN_PATHWAY%MSIGDB_C2%BIOCARTA_UCALPAIN_PATHWAY BIOCARTA_UCALPAIN_PATHWAY 22350 21894 11459 19353 16416 20740 11848 14083 16412 19303 11474 109711 109700 20779 12333 11472 69543 12336 PID_HEDGEHOG_GLI_PATHWAY%MSIGDB_C2%PID_HEDGEHOG_GLI_PATHWAY PID_HEDGEHOG_GLI_PATHWAY 19646 20466 14687 15376 26395 14681 14633 56469 243369 11651 319757 14634 70425 19206 93687 24069 18747 21821 104318 20423 27373 14632 103583 103573 433759 19335 16568 18753 211401 67661 103236 14702 214897 269209 14688 216869 60406 100041953 14679 20467 16854 12914 14677 56637 15182 20747 245688 14678 PID_REELIN_PATHWAY%MSIGDB_C2%PID_REELIN_PATHWAY PID_REELIN_PATHWAY 14811 17755 26419 11651 16412 18472 22359 19099 26400 18708 14812 16400 17974 16800 18706 12929 107746 16976 109905 12568 14360 12402 13131 19699 56637 26403 12569 PID_TCR_PATHWAY%MSIGDB_C2%PID_TCR_PATHWAY PID_TCR_PATHWAY 53859 192176 26411 240354 22034 12675 11651 22376 12519 53416 16822 16151 12487 23880 26410 17973 18803 16428 12524 14360 16150 14784 18750 19211 15461 94212 19419 18607 16331 14389 19247 12500 12501 12502 20416 12503 12988 18176 20662 19264 64177 16818 19395 77799 22637 108723 54354 14968 24055 16797 109305 20866 14969 12504 22324 18751 16653 109905 18754 12402 13169 18761 12042 15170 17444 BIOCARTA_CTLA4_PATHWAY%MSIGDB_C2%BIOCARTA_CTLA4_PATHWAY BIOCARTA_CTLA4_PATHWAY 16818 12487 16183 14968 18708 14969 12477 54167 19247 12519 18706 16428 12500 12524 12501 12502 50723 12503 14784 PID_TOLL_ENDOGENOUS_PATHWAY%MSIGDB_C2%PID_TOLL_ENDOGENOUS_PATHWAY PID_TOLL_ENDOGENOUS_PATHWAY 20201 20387 15510 12675 20202 12111 266632 21897 434174 16151 20210 12475 106759 24088 17874 11848 108960 21898 142980 21899 13003 16150 16179 17087 117149 BIOCARTA_FMLP_PATHWAY%MSIGDB_C2%BIOCARTA_FMLP_PATHWAY BIOCARTA_FMLP_PATHWAY 110157 15461 18035 18705 26401 26395 19697 26396 18479 640703 26413 215303 13712 52163 18033 26417 18019 26399 18018 73181 14688 19057 14293 26397 17970 19055 19056 19353 18021 14699 14676 26416 18795 BIOCARTA_NEUROTRANSMITTERS_PATHWAY%MSIGDB_C2%BIOCARTA_NEUROTRANSMITTERS_PATHWAY BIOCARTA_NEUROTRANSMITTERS_PATHWAY 21823 14415 15186 13166 18948 21990 BIOCARTA_FAS_PATHWAY%MSIGDB_C2%BIOCARTA_FAS_PATHWAY BIOCARTA_FAS_PATHWAY 13368 12368 13347 14103 11545 26401 16906 26419 12370 19645 12367 12633 20740 26409 18479 12369 14102 13163 14084 192656 19249 224105 16905 14082 26398 11857 16907 19090 16476 BIOCARTA_HSP27_PATHWAY%MSIGDB_C2%BIOCARTA_HSP27_PATHWAY BIOCARTA_HSP27_PATHWAY 69253 12043 13163 14103 11459 670717 15507 12367 12371 17164 21926 102626 11783 16175 14102 PID_CD8_TCR_PATHWAY%MSIGDB_C2%PID_CD8_TCR_PATHWAY PID_CD8_TCR_PATHWAY 53859 240354 22034 12675 11651 12519 16822 16151 12487 12526 26410 12010 12525 15007 18803 12524 14360 16150 14784 18750 15461 94212 18646 19419 18607 12500 12501 12502 20416 12503 12988 18176 19264 20662 64177 16818 19395 22637 108723 54354 109305 16797 20866 22324 18751 16653 109905 18754 12402 18761 15170 12042 17444 ST_P38_MAPK_PATHWAY%MSIGDB_C2%ST_P38_MAPK_PATHWAY ST_P38_MAPK_PATHWAY 12913 22034 11651 17164 13684 20807 17347 26409 22026 26408 17346 13631 19252 100040260 26415 26413 13712 12912 19094 26407 18033 269881 29857 17165 26399 17876 16177 15507 26397 26398 63953 26416 66513 68652 13197 PID_ARF6_DOWNSTREAM_PATHWAY%MSIGDB_C2%PID_ARF6_DOWNSTREAM_PATHWAY PID_ARF6_DOWNSTREAM_PATHWAY 18806 26417 18805 21844 19353 215445 11848 18793 26413 545156 11840 18102 11845 18720 53869 PID_AJDISS_2PATHWAY%MSIGDB_C2%PID_AJDISS_2PATHWAY PID_AJDISS_2PATHWAY 13645 11487 15461 12387 13430 16002 12550 29875 21844 14585 19713 12367 19246 13649 16001 15239 17393 11845 11350 56440 20562 17392 109620 19876 56805 19353 271457 12064 104836 12558 74030 14573 17288 12914 17295 14674 63955 18212 14360 12388 14673 18102 20779 15170 19349 16480 12385 PID_MET_PATHWAY%MSIGDB_C2%PID_MET_PATHWAY PID_MET_PATHWAY 56705 12387 12928 12550 16211 16332 26419 11652 70584 224116 11651 19271 15234 11845 23871 26417 18708 74370 67605 18762 20613 12015 224105 17973 19353 11848 26398 17974 18803 18759 18706 14064 11789 17295 19303 56513 73178 16476 226970 14784 12927 110157 15461 13858 58194 26401 26395 26396 19246 13684 18607 16331 14389 18479 19247 14083 26413 18222 13685 15239 56717 20416 19255 56716 20662 97998 20404 13653 271457 74030 12929 107746 109905 14388 12402 20779 74334 215449 12385 PID_PRL_SIGNALING_EVENTS_PATHWAY%MSIGDB_C2%PID_PRL_SIGNALING_EVENTS_PATHWAY PID_PRL_SIGNALING_EVENTS_PATHWAY 26417 19877 12447 11606 12566 13653 19353 11848 19244 56187 19245 22143 26413 107503 19352 16412 11853 12575 109700 20779 12428 12927 HALLMARK_OXIDATIVE_PHOSPHORYLATION%MSIGDB_C2%HALLMARK_OXIDATIVE_PHOSPHORYLATION HALLMARK_OXIDATIVE_PHOSPHORYLATION 59054 66052 11931 66925 68202 211253 66945 18242 17448 66525 20916 94065 14194 69772 12039 17449 78830 11370 13382 69597 14661 56451 15929 381511 52538 93747 14148 108664 67460 66091 110842 69833 636544 11973 30055 110826 30056 30057 97212 30059 66152 100039636 67994 110446 66885 17713 59040 70383 24030 433923 226139 66865 114143 109754 72416 100041785 223696 57279 210009 66407 66223 18105 27060 64655 66419 68197 55951 11974 100041835 18293 68375 74143 16832 18115 67863 16828 14751 11958 66495 15926 66043 110323 14297 67264 11757 67003 230075 12866 66445 66694 70316 17992 66046 225887 12857 17991 227197 73834 17993 66108 67530 11947 11949 100042918 17995 18674 75406 228033 27402 69802 170731 68198 227112 226646 625249 54405 11740 269951 104776 64704 54411 20930 11946 16922 51798 66377 11950 66290 11739 69089 72900 66416 623286 20463 100039108 53375 57423 109731 12856 109672 22334 338359 27273 214952 12369 22335 67442 18984 100042503 113868 11655 670717 67130 11429 66335 22333 15526 22272 66841 432676 12034 624814 12028 12861 66916 12894 13177 66142 12868 170718 66144 11957 66383 15108 26926 235339 66447 231086 76614 14719 78920 67680 67834 68263 15159 22273 12858 12974 28185 18597 100040287 11364 BIOCARTA_PTEN_PATHWAY%MSIGDB_C2%BIOCARTA_PTEN_PATHWAY BIOCARTA_PTEN_PATHWAY 19211 26417 14103 18708 56484 11651 16202 18607 14083 26413 18706 16412 12576 18604 20416 14784 20662 12927 BIOCARTA_SPPA_PATHWAY%MSIGDB_C2%BIOCARTA_SPPA_PATHWAY BIOCARTA_SPPA_PATHWAY 18750 110157 26417 15461 20963 14062 14061 14688 26395 14065 19224 21391 18751 14699 14083 26413 16412 14677 109700 18795 20779 18783 PID_LPA4_PATHWAY%MSIGDB_C2%PID_LPA4_PATHWAY PID_LPA4_PATHWAY 14680 11515 432530 11514 104110 18747 73086 210044 11513 11512 12912 78134 104111 18754 224129 ST_T_CELL_SIGNAL_TRANSDUCTION%MSIGDB_C2%ST_T_CELL_SIGNAL_TRANSDUCTION ST_T_CELL_SIGNAL_TRANSDUCTION 110157 228550 18035 18036 20663 19419 70584 18481 214230 241656 12477 18479 26413 12500 320404 18033 16822 12988 19264 20662 13138 16818 240168 22637 19395 13844 12487 233046 16797 54446 17973 224105 22324 50754 18477 18038 18037 18803 72749 18034 16428 21915 12402 14784 17444 PID_FAK_PATHWAY%MSIGDB_C2%PID_FAK_PATHWAY PID_FAK_PATHWAY 12928 232906 22612 20405 245671 26419 20130 330662 30957 16410 16419 23871 54126 26420 18708 17973 14786 17387 19353 11848 26398 17974 26431 18803 18706 12334 213498 13196 19303 109711 14360 73178 16476 14784 12927 110157 109880 21894 26395 110596 12169 18479 26413 14083 16402 16412 19878 20662 218397 71302 11459 140580 24000 107746 109905 22330 20779 215449 12443 BIOCARTA_BARRESTIN_PATHWAY%MSIGDB_C2%BIOCARTA_BARRESTIN_PATHWAY BIOCARTA_BARRESTIN_PATHWAY 11773 13429 14699 11771 109689 14688 18795 19013 432530 PID_P38_GAMMA_DELTA_PATHWAY%MSIGDB_C2%PID_P38_GAMMA_DELTA_PATHWAY PID_P38_GAMMA_DELTA_PATHWAY 16765 13631 26399 26415 26397 20648 65964 320795 29857 12443 PID_PI3K_PLC_TRK_PATHWAY%MSIGDB_C2%PID_PI3K_PLC_TRK_PATHWAY PID_PI3K_PLC_TRK_PATHWAY 15461 100039786 22065 22628 22631 54401 56484 11651 12322 18607 12326 12912 18049 18211 20416 22629 20850 18753 18176 20662 22627 18708 216439 13653 55948 12015 16653 193034 18803 18706 14388 56637 20779 14784 12443 BIOCARTA_TCYTOTOXIC_PATHWAY%MSIGDB_C2%BIOCARTA_TCYTOTOXIC_PATHWAY BIOCARTA_TCYTOTOXIC_PATHWAY 16408 21838 12487 16414 12500 12501 12502 12503 12525 15894 19264 12481 PID_PTP1B_PATHWAY%MSIGDB_C2%PID_PTP1B_PATHWAY PID_PTP1B_PATHWAY 12928 14158 12143 22612 18591 11651 16334 50490 22608 16337 18596 14131 19116 12977 18708 11848 12991 18706 14360 12333 14784 12927 13645 24064 22166 12389 16367 19246 16847 20848 13649 16846 16452 20416 20850 12988 20851 54721 64177 16818 17096 16797 16416 16399 13448 19109 12558 14191 12702 15162 12978 20779 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES%MSIGDB_C2%SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES 19159 19211 16439 320207 20111 277360 110651 228026 11652 21981 16438 23797 56484 11651 23957 628705 16440 20215 19264 26377 20963 17096 20112 18124 110279 12478 22324 14252 12578 18706 18741 14251 234779 12229 14388 BIOCARTA_PML_PATHWAY%MSIGDB_C2%BIOCARTA_PML_PATHWAY BIOCARTA_PML_PATHWAY 21938 15461 13163 14103 18854 19401 19645 21937 21926 93759 378460 12914 14102 22059 18505 ST_INTERLEUKIN_13_PATHWAY%MSIGDB_C2%ST_INTERLEUKIN_13_PATHWAY ST_INTERLEUKIN_13_PATHWAY 16451 16190 16165 16452 16163 16164 54721 BIOCARTA_RACCYCD_PATHWAY%MSIGDB_C2%BIOCARTA_RACCYCD_PATHWAY BIOCARTA_RACCYCD_PATHWAY 110157 15461 18035 12447 19697 12566 19645 12675 11651 18479 26413 18033 16151 26417 13555 21781 18708 12567 19353 11848 18706 12576 12575 16150 12571 12443 BIOCARTA_ETS_PATHWAY%MSIGDB_C2%BIOCARTA_ETS_PATHWAY BIOCARTA_ETS_PATHWAY 23871 20602 13555 23872 15461 12977 19651 20466 19650 27049 53975 104394 20467 14281 15182 12978 15184 16476 PID_LKB1_PATHWAY%MSIGDB_C2%PID_LKB1_PATHWAY PID_LKB1_PATHWAY 100039786 22084 22628 15519 22631 54401 19082 105787 18612 108079 75770 70661 18747 19165 17691 19079 64930 71728 12912 72149 56717 13728 70415 381979 56716 20869 22629 235344 74343 227154 17128 232944 22627 22350 74370 13033 67605 55948 13982 12539 12283 66993 22059 56637 17869 BIOCARTA_HIVNEF_PATHWAY%MSIGDB_C2%BIOCARTA_HIVNEF_PATHWAY BIOCARTA_HIVNEF_PATHWAY 53859 18035 22030 19697 26419 12537 12370 71609 227753 12675 12633 12905 20740 19164 19165 12369 18033 101706 18753 21938 26400 670717 224105 67384 21937 14082 19766 13368 13347 12368 12043 11797 14103 12122 11545 22029 26401 16906 19645 12367 12371 26408 14083 14102 13163 218397 11798 16905 12366 21926 11783 11857 16907 17246 19090 11465 11796 PID_SYNDECAN_3_PATHWAY%MSIGDB_C2%PID_SYNDECAN_3_PATHWAY PID_SYNDECAN_3_PATHWAY 208117 11604 17202 13043 19164 100039623 13649 59287 100042305 13004 20970 12361 19242 14360 18976 20779 PID_MYC_PATHWAY%MSIGDB_C2%PID_MYC_PATHWAY PID_MYC_PATHWAY 100683 22642 14534 216185 66464 27401 73389 19052 108143 18854 20174 17187 226849 72195 224105 109115 50754 23988 12578 81601 56505 56456 12005 56637 17869 BIOCARTA_HIF_PATHWAY%MSIGDB_C2%BIOCARTA_HIF_PATHWAY BIOCARTA_HIF_PATHWAY 15251 18127 18453 16828 22346 11863 65973 22339 15519 12912 26754 328572 16476 13614 13856 BIOCARTA_COMP_PATHWAY%MSIGDB_C2%BIOCARTA_COMP_PATHWAY BIOCARTA_COMP_PATHWAY 17175 12263 14962 109828 12274 15139 625018 17195 12262 12259 667277 317677 12260 230558 12279 11537 12266 BIOCARTA_MET_PATHWAY%MSIGDB_C2%BIOCARTA_MET_PATHWAY BIOCARTA_MET_PATHWAY 19211 110157 15461 12928 26411 26395 26396 26419 19229 20848 19247 18479 26413 14083 14281 16412 13712 330662 15234 109700 20662 26417 218397 18708 11459 30955 18706 12929 17295 107746 19303 109905 14388 20779 16476 215449 14784 PID_CIRCADIAN_PATHWAY%MSIGDB_C2%PID_CIRCADIAN_PATHWAY PID_CIRCADIAN_PATHWAY 18627 18143 12953 11865 12649 53610 140858 217166 12753 12952 21853 18626 27373 20893 ST_FAS_SIGNALING_PATHWAY%MSIGDB_C2%ST_FAS_SIGNALING_PATHWAY ST_FAS_SIGNALING_PATHWAY 18035 18036 22030 26419 66593 12370 72119 14299 19765 93687 18033 30957 26420 26400 19877 26414 15507 14082 19766 26398 18038 20597 18037 72749 18034 18645 17295 26885 72393 13347 69719 233870 11545 12028 26401 12516 12367 13649 26408 26413 23957 14102 12018 60597 19099 21945 13163 13844 13445 22350 56737 67379 14084 11798 54446 15463 19249 16175 18643 12229 22059 HALLMARK_E2F_TARGETS%MSIGDB_C2%HALLMARK_E2F_TARGETS HALLMARK_E2F_TARGETS 56403 17865 68278 17219 17215 100039535 18817 27354 11991 20382 69263 19360 19718 18973 68275 19355 230484 17218 50927 15354 67196 20842 100039474 67967 11637 17345 14375 12567 13433 15366 110074 72391 18813 56452 20873 12576 17216 56419 30939 56150 14056 19357 19385 17217 12419 12447 22042 21877 16881 101565 114714 67134 68240 66979 110750 18971 218210 12578 12575 12189 16765 20937 73804 100039592 20877 70099 20878 53892 21335 103573 21973 26934 53605 110052 54124 12190 24061 15574 12580 18972 12530 17220 12442 12534 15270 12531 20833 51788 19891 18393 14852 19076 16201 18538 13018 21917 16906 15374 98386 20462 229841 12021 13006 110033 12649 11799 107995 105988 16571 15361 70769 18969 100710 19090 110809 50883 97165 18102 17869 22390 218977 26951 20425 69724 51797 70699 66131 21853 66471 17685 22256 68298 19384 17768 52276 20135 67629 12236 103733 68219 17350 53381 18861 19687 17535 15201 66422 21379 13665 69716 67054 67684 66403 67241 233726 52592 106795 20492 14793 70472 54141 66929 106618 19362 108961 212377 60364 109145 76522 17279 19139 58184 66622 72107 22154 13626 13178 140917 69270 12704 103135 69639 103468 76131 101739 20638 66442 70218 78833 66570 100336 71777 22059 74097 17089 68479 19183 18949 17121 245688 BIOCARTA_GLEEVEC_PATHWAY%MSIGDB_C2%BIOCARTA_GLEEVEC_PATHWAY BIOCARTA_GLEEVEC_PATHWAY 26417 110157 15461 18708 30955 26395 26401 26419 110279 12015 11651 26398 14281 18706 12929 16452 20846 17869 20850 16476 20851 14784 20662 PID_NFAT_TFPATHWAY%MSIGDB_C2%PID_NFAT_TFPATHWAY PID_NFAT_TFPATHWAY 381319 16184 14103 16183 13655 16477 13654 18986 19225 57765 12367 19246 13139 12477 66889 17254 14281 19272 12981 16396 21888 16364 21947 14283 20371 15978 13555 18019 16191 18018 13656 13653 12567 208650 18021 19016 21926 14462 17132 22778 18761 16476 16189 BIOCARTA_BARR_MAPK_PATHWAY%MSIGDB_C2%BIOCARTA_BARR_MAPK_PATHWAY BIOCARTA_BARR_MAPK_PATHWAY 26417 13429 110157 14699 26413 109689 14688 26395 26396 18795 432530 BIOCARTA_TID_PATHWAY%MSIGDB_C2%BIOCARTA_TID_PATHWAY BIOCARTA_TID_PATHWAY 15978 21938 15979 18035 83945 15980 19697 19645 21937 193740 21926 22431 108030 100039683 16452 22059 18033 72088 16150 PID_TCR_RAS_PATHWAY%MSIGDB_C2%PID_TCR_RAS_PATHWAY PID_TCR_RAS_PATHWAY 18750 110157 26417 15461 320139 109880 26410 26395 18751 16653 26413 14281 13712 18176 BIOCARTA_SALMONELLA_PATHWAY%MSIGDB_C2%BIOCARTA_SALMONELLA_PATHWAY BIOCARTA_SALMONELLA_PATHWAY 66713 56443 76709 68089 83767 67771 11459 73178 56378 19353 74117 11867 BIOCARTA_FCER1_PATHWAY%MSIGDB_C2%BIOCARTA_FCER1_PATHWAY BIOCARTA_FCER1_PATHWAY 110157 15461 26401 26395 26419 14127 640703 26413 14281 13712 20416 18783 20662 26417 20963 18019 18018 26400 17096 73181 18708 19057 30955 19055 224105 19056 22324 18021 26398 18751 18803 18706 12229 14125 16476 14784 BIOCARTA_DC_PATHWAY%MSIGDB_C2%BIOCARTA_DC_PATHWAY BIOCARTA_DC_PATHWAY 15978 16411 16191 230398 170743 12516 16153 24088 16163 12507 12481 81897 21898 15977 16790 12981 21939 16160 16159 16189 FANCONI ANEMIA PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FANCONI ANEMIA PATHWAY Fanconi anemia pathway 14087 67196 233826 103583 69928 106344 12234 15574 19360 211651 14088 72151 68275 19367 21975 12649 330554 17535 19356 12189 72775 71885 60534 12144 104806 69263 15270 19718 67561 208836 74335 19355 11920 235610 27354 15205 235559 101831 230484 12190 19891 67030 237911 237211 100040608 IL8-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL8-MEDIATED SIGNALING EVENTS IL8-mediated signaling events FOXA2 AND FOXA3 TRANSCRIPTION FACTOR NETWORKS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXA2 AND FOXA3 TRANSCRIPTION FACTOR NETWORKS FOXA2 and FOXA3 transcription factor networks 11370 11806 12606 71911 12609 22139 15227 15378 78070 103988 14061 21405 12608 15107 15377 20526 11576 22228 16006 14815 20927 230163 18609 15376 22042 18015 16334 21869 12894 18534 11657 11364 15375 12895 11655 18770 16514 234724 11651 14377 13386 12912 100040592 20683 IL5-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL5-MEDIATED SIGNALING EVENTS IL5-mediated signaling events 18706 12984 18712 17096 16452 16192 19247 53378 12700 18708 14784 20850 20851 16191 SYNDECAN-4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-4-MEDIATED SIGNALING EVENTS Syndecan-4-mediated signaling events 18750 11848 16772 67903 14083 17395 18753 14268 11489 16774 14061 13430 14177 16412 20315 14182 20304 53378 57916 66911 21825 18815 17242 19353 14173 21923 20971 21788 14369 16402 12767 109711 BCR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BCR SIGNALING PATHWAY BCR signaling pathway 240354 108723 13712 20662 100039026 26413 16151 18036 19264 18987 14130 20416 110157 26416 12675 15461 16476 26419 16150 26409 12518 13448 26395 12483 18607 12517 22325 18033 23871 18035 26411 19697 26417 218397 15985 12229 12988 20963 22034 12478 17060 19211 12047 19057 15170 26377 26401 14281 108837 18018 640703 19056 234779 12325 19055 12042 94212 24056 18708 14784 19353 18706 17096 11651 AURORA B SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AURORA B SIGNALING Aurora B signaling 11848 54204 14020 13346 12615 19047 218397 21770 22352 23980 73804 20877 14211 320165 107589 12419 16319 72415 68298 242521 16765 28114 26554 70099 52276 20878 71819 19348 12235 67455 26934 18148 215387 11799 19167 67052 N-CADHERIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%N-CADHERIN SIGNALING EVENTS N-cadherin signaling events 11848 269060 14432 18717 12801 16573 17906 12558 231871 14182 12388 14158 227753 13191 18708 26419 16480 19877 13043 14800 16973 12385 13589 18803 12005 19353 12387 19246 14609 18706 19247 640703 12325 REGULATION OF TELOMERASE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF TELOMERASE Regulation of Telomerase 57321 21951 100041953 245474 101185 433759 26413 20687 72400 21749 28113 21750 16476 15574 19360 18033 20467 19367 56717 26417 13555 17187 17535 11350 19646 22431 13982 20466 245688 16362 12144 22596 103677 13645 15976 15519 14281 21752 12443 19355 13649 11920 12576 17127 27354 17119 15978 21803 15182 14375 22627 229512 11819 16183 11546 60406 100043508 17869 22215 98999 15381 22427 497652 11651 20683 TRK RECEPTOR SIGNALING MEDIATED BY PI3K AND PLC-GAMMA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TRK RECEPTOR SIGNALING MEDIATED BY PI3K AND PLC-GAMMA Trk receptor signaling mediated by PI3K and PLC-gamma 20662 18753 56637 18211 55948 22628 20416 100039786 15461 12015 18049 18708 20779 14784 54401 20850 22629 22065 13653 16653 193034 18607 18176 14388 18803 22631 12326 12322 56484 216439 18706 12443 22627 11651 12912 ROLE OF CALCINEURIN-DEPENDENT NFAT SIGNALING IN LYMPHOCYTES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ROLE OF CALCINEURIN-DEPENDENT NFAT SIGNALING IN LYMPHOCYTES Role of Calcineurin-dependent NFAT signaling in lymphocytes 100039026 56637 55948 22628 26416 100039786 12015 26419 54401 22629 22631 12326 26417 26401 18018 640703 22627 18750 18753 18747 56398 14225 19384 14232 18021 18019 12043 238276 18754 18752 18751 18712 54720 15370 26420 18755 12048 16211 328572 100039592 53901 227720 93687 104248 12367 18762 12914 26410 17261 18761 103573 IL6-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL6-MEDIATED SIGNALING EVENTS IL6-mediated signaling events 229615 232345 17869 17342 56469 20662 20846 12609 20848 18753 54721 99571 15162 22027 19267 56458 12608 26398 16477 26416 22324 26399 16193 16476 21857 16803 18708 14784 12702 17210 16451 16194 21943 12944 16911 16195 14388 19094 19353 18706 16362 16452 19247 12048 14281 11651 14389 MTOR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%MTOR SIGNALING PATHWAY mTOR signaling pathway 26413 227743 20787 55948 22628 52187 109880 26396 110157 16367 100039786 18806 15461 54401 103583 16150 22629 12234 16653 26395 18607 18176 22631 13629 22241 56717 26417 78757 13685 75705 20111 109270 20393 73826 22084 245670 19017 13631 56716 74370 12421 68441 74747 12566 22632 106298 18805 97998 670717 51897 12447 100042570 22627 18569 13684 54170 13681 18854 18750 64930 29869 56430 67605 11651 SIGNALING EVENTS MEDIATED BY THE HEDGEHOG FAMILY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY THE HEDGEHOG FAMILY Signaling events mediated by the Hedgehog family 14633 110355 117606 226861 19227 14725 19206 20423 18706 13363 18708 20460 21808 16147 19207 216869 11651 15245 57810 16976 14451 319757 SYNDECAN-3-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-3-MEDIATED SIGNALING EVENTS Syndecan-3-mediated signaling events 13004 19242 12361 64654 14184 208117 11604 100042305 14186 19164 100039623 14360 59287 13649 20779 20970 17202 13043 14170 18976 ATYPICAL NF-KAPPAB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATYPICAL NF-KAPPAB PATHWAY Atypical NF-kappaB pathway 19697 12051 19696 20963 16818 18706 26416 20779 18708 16150 12234 216869 18033 18035 ARF1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF1 PATHWAY Arf1 pathway 12847 228998 18806 12757 76932 11771 74325 12504 19158 56494 11773 11840 260302 18720 19353 56041 13196 68137 107338 EGFR-DEPENDENT ENDOTHELIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EGFR-DEPENDENT ENDOTHELIN SIGNALING EVENTS EGFR-dependent Endothelin signaling events 15461 56717 13649 14784 20662 13617 13614 20416 13645 ATR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATR SIGNALING PATHWAY ATR signaling pathway 12428 21853 17246 17220 54380 12530 214552 23834 18817 19361 12532 17216 19052 66131 51792 54401 103583 106344 12234 15574 72930 269582 22631 211651 72151 68275 19367 12649 19356 69263 19718 12566 19355 235610 27354 235559 12190 19891 FOXA TRANSCRIPTION FACTOR NETWORKS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXA TRANSCRIPTION FACTOR NETWORKS FOXA transcription factor networks 15376 15375 15377 S1P3 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P3 PATHWAY S1P3 pathway 11848 26413 14687 13610 20779 14679 14673 14676 14674 14672 14678 14677 14675 14254 22339 14682 18596 19353 18591 23797 14681 26417 16452 11651 12767 SHP2 SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SHP2 SIGNALING SHP2 signaling 20662 18211 20416 110157 26396 16367 15461 18049 26395 16653 18176 14388 13645 13649 15978 94212 16183 11848 20846 16186 16453 16001 107971 16542 18212 18127 16193 18205 15529 18708 21687 14679 14784 15979 18213 16451 78405 16194 12064 232906 14677 16911 16195 22339 327826 17356 18596 16185 18591 11600 16184 18747 16818 18706 16452 19247 14389 IL2 SIGNALING EVENTS MEDIATED BY PI3K%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL2 SIGNALING EVENTS MEDIATED BY PI3K IL2 signaling events mediated by PI3K 17869 20662 16186 16453 20416 18708 14784 16451 19353 18033 16185 56484 16184 19697 56717 13555 16818 12043 667739 18706 22234 208449 13669 20597 15519 19247 12048 21752 640703 17863 18762 11651 14389 16183 EPHA FORWARD SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHA FORWARD SIGNALING EPHA forward signaling 13637 11848 13840 12928 13838 13837 13636 13638 22612 15162 30955 14360 20779 19877 18803 22325 16818 17096 14191 13841 12402 12143 57257 13836 104709 13839 12568 13835 13640 13842 53972 12929 442801 P38 MAPK SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P38 MAPK SIGNALING PATHWAY p38 MAPK signaling pathway 26416 26399 26409 26406 22166 19094 19353 53608 269881 26407 26397 22030 13197 68652 330177 216527 23882 66513 17873 22034 216965 26408 12323 26401 640703 11920 IL3-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL3-MEDIATED SIGNALING EVENTS IL3-mediated signaling events 18747 433759 18706 12984 22628 18712 20416 12608 16452 19247 12048 12700 18708 14784 194231 20850 18413 27058 20851 16188 18749 15901 22631 14389 REELIN SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REELIN SIGNALING PATHWAY Reelin signaling pathway 18472 22359 13131 56637 26400 19699 16800 107746 109905 16412 14812 26403 14811 14360 17755 16400 17974 18708 26419 12569 16976 18706 12402 12568 11651 12929 VEGFR1 SPECIFIC SIGNALS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VEGFR1 SPECIFIC SIGNALS VEGFR1 specific signals 12488 18750 18186 18187 12389 26413 17973 18127 18708 18607 18803 14254 22339 18747 26417 218397 18706 18751 15519 19247 12402 640703 11651 18654 15251 22340 216148 ARF6 TRAFFICKING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF6 TRAFFICKING EVENTS Arf6 trafficking events 18717 13430 16412 12388 18806 69940 104099 16400 241226 107371 16593 30948 22319 20528 12385 12387 213119 24044 11845 11555 20336 319480 67300 16334 11607 22095 16401 16410 216859 12550 211446 30957 53413 105504 18102 16398 211914 12000 18805 16404 12876 56044 70834 16403 109700 66482 16402 CALCIUM SIGNALING IN THE CD4+ TCR PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CALCIUM SIGNALING IN THE CD4+ TCR PATHWAY Calcium signaling in the CD4+ TCR pathway 16477 16476 12981 381319 14103 14283 19225 21947 18986 16184 16189 18747 56398 14225 18021 18019 238276 54720 14281 18018 640703 53901 15978 104248 16183 INTEGRIN FAMILY CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTEGRIN FAMILY CELL SURFACE INTERACTIONS Integrin family cell surface interactions 16407 16399 320910 16408 16409 381924 16414 16411 16421 16420 16419 192897 16416 16412 16400 104099 241226 213119 319480 16401 16410 16398 16404 16403 109700 16402 RAPID GLUCOCORTICOID SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RAPID GLUCOCORTICOID SIGNALING Rapid glucocorticoid signaling 26419 14702 19094 12918 14680 26420 26416 14688 GLYPICAN 3 NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN 3 NETWORK Glypican 3 network 12159 14734 14178 26419 19206 18550 20423 26420 VEGFR3 SIGNALING IN LYMPHATIC ENDOTHELIUM%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VEGFR3 SIGNALING IN LYMPHATIC ENDOTHELIUM VEGFR3 signaling in lymphatic endothelium 12928 20662 26413 14268 26398 20416 16412 26416 18708 14784 19094 26417 20111 18706 16401 16398 14257 12842 12843 22341 109700 11651 14205 12912 16402 GMCSF-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GMCSF-MEDIATED SIGNALING EVENTS GMCSF-mediated signaling events 20662 20846 20848 26413 20416 26396 110157 15461 12700 18708 16150 14784 20850 18413 20851 16653 26395 12981 18176 18749 22631 18747 26417 20963 18706 12984 18712 17096 16452 19247 14281 20293 12982 14389 15900 PROTEOGLYCAN SYNDECAN-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PROTEOGLYCAN SYNDECAN-MEDIATED SIGNALING EVENTS Proteoglycan syndecan-mediated signaling events 15529 20970 20969 20971 RAC1 SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RAC1 SIGNALING PATHWAY RAC1 signaling pathway 26400 26416 26403 241275 16476 56378 26419 74117 76709 17970 242687 71893 83767 67771 68089 237038 66713 224105 11909 18719 26397 329165 12550 26401 12928 20848 18717 26398 26399 20850 12385 19353 12387 11855 192662 11308 13057 17969 18796 50884 13058 12631 16885 101314 76884 12927 18479 26420 108100 404710 26934 18720 29875 11867 EPHA2 FORWARD SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHA2 FORWARD SIGNALING EPHA2 forward signaling 11848 14083 16332 13636 11431 21844 18706 20416 12927 18479 12402 20779 18708 14784 57257 13836 232906 22325 19353 NETRIN-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NETRIN-MEDIATED SIGNALING EVENTS Netrin-mediated signaling events 330662 11848 18208 17909 69635 14083 26413 17973 73178 22612 18738 13176 107449 223435 26396 22253 140580 107448 14360 17755 20779 18708 26395 18803 19353 12322 216439 26417 18706 12927 18479 ALPHA9 BETA1 INTEGRIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA9 BETA1 INTEGRIN SIGNALING EVENTS Alpha9 beta1 integrin signaling events 14268 11489 20229 16412 104099 20779 12981 22339 19353 21923 12927 212503 19303 11501 11495 20750 21817 22329 74145 12982 22341 14205 11490 18126 16516 CANONICAL NF-KAPPAB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CANONICAL NF-KAPPAB PATHWAY Canonical NF-kappaB pathway 19697 18750 240354 19384 257632 192656 11797 22034 16151 21929 12675 11920 16150 12234 21937 12042 21926 74256 66105 18033 111173 18035 103573 VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL REPRESSION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL REPRESSION Validated targets of C-MYC transcriptional repression 12606 12609 433759 56484 13435 22418 17126 17187 12575 12189 13198 56363 22084 18045 21673 18044 21374 12579 18046 12443 12576 17127 16403 12192 17869 14581 20375 12633 15902 17128 16852 13380 23894 20377 56752 15360 192897 16412 15183 13866 21873 20304 17988 12759 22642 29811 18173 19650 94280 66271 14319 18596 229663 110854 17122 13197 12043 328572 12843 12912 15900 20683 NONGENOTROPIC ANDROGEN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NONGENOTROPIC ANDROGEN SIGNALING Nongenotropic Androgen signaling 14083 26413 26396 110157 14688 15461 14714 14687 18708 20779 14679 20415 18797 18795 11835 26395 14678 14677 18803 19353 14681 26417 18796 18706 75273 14281 14702 234779 11651 12912 FAS (CD95) SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FAS (CD95) SIGNALING PATHWAY FAS (CD95) signaling pathway 12633 16151 26400 26416 12675 26399 20779 18708 26419 16150 18607 14103 19094 14082 11796 19687 74769 12229 11797 20963 67300 18706 12370 19766 72393 12122 26414 14102 26420 20597 22350 26401 12367 11651 ALPHA-SYNUCLEIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA-SYNUCLEIN SIGNALING Alpha-synuclein signaling 100039026 18753 22612 15162 18806 12015 14360 20779 14225 21770 14773 18796 21823 20963 30931 16818 56424 17096 14191 22223 12143 18805 19229 19144 50873 57320 22195 20617 13162 109731 P63 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P63 TRANSCRIPTION FACTOR NETWORK p63 transcription factor network 22061 DNA-PK PATHWAY IN NONHOMOLOGOUS END JOINING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DNA-PK PATHWAY IN NONHOMOLOGOUS END JOINING DNA-PK pathway in nonhomologous end joining 319583 21673 22596 72103 75570 56626 54125 66408 58182 227525 19090 108138 59047 14375 SIGNALING EVENTS MEDIATED BY VEGFR1 AND VEGFR2%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY VEGFR1 AND VEGFR2 Signaling events mediated by VEGFR1 and VEGFR2 22330 14783 19271 12389 15239 15516 226101 26413 17973 17999 17164 14159 19255 207565 109880 26396 110157 26416 14360 17974 20779 103583 26395 18607 14388 22370 224105 27371 11640 12562 26397 230126 26417 16410 15170 15519 19303 640703 18750 11848 14083 18753 13430 16542 16416 18127 26399 18708 14784 19877 12385 22339 18803 14254 19094 12387 18747 18706 18751 19247 12402 19229 11840 11651 29875 SIGNALING EVENTS MEDIATED BY HDAC CLASS III%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HDAC CLASS III Signaling events mediated by HDAC Class III 56458 64383 50709 14200 68738 64384 93759 22059 22143 12028 60525 208727 56484 12575 209011 17927 19017 54601 22151 18519 15395 328572 14375 12914 17261 ALPHA4 BETA1 INTEGRIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA4 BETA1 INTEGRIN SIGNALING EVENTS Alpha4 beta1 integrin signaling events 330662 12928 14083 14268 16412 20779 21825 18749 17242 22631 19353 18747 17882 12520 11308 11845 140559 13522 21826 12475 19085 216963 16401 21894 19084 12927 19303 20750 22329 19229 19262 67374 270152 P75(NTR)-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P75(NTR)-MEDIATED SIGNALING p75(NTR)-mediated signaling 16151 18211 20416 12675 12015 18049 59287 26419 16150 22059 18749 13555 192656 11797 22034 11852 66647 11491 11853 11798 94275 12368 12371 670717 20598 18759 17392 22627 17393 18412 12125 11848 18053 17136 17874 20661 68585 65079 16179 75625 18377 17984 11820 12070 11783 66593 19716 18205 18708 72843 170936 78405 12064 18815 19353 192662 11796 18706 208117 100042305 26414 19164 26420 100039623 18550 12367 18762 11651 WNT SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%WNT SIGNALING NETWORK Wnt signaling network 13380 16010 22416 26564 70495 14367 14362 16973 57265 93897 14371 84035 16974 22421 192199 22408 22422 22418 22413 14370 22415 73016 24117 14366 68588 20187 14368 14369 TRK RECEPTOR SIGNALING MEDIATED BY THE MAPK PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TRK RECEPTOR SIGNALING MEDIATED BY THE MAPK PATHWAY Trk receptor signaling mediated by the MAPK pathway 13712 26413 18753 17164 109880 109905 110157 26416 26399 15461 18205 12569 13653 16653 26395 193034 18176 26397 26417 20111 215449 98878 73086 19762 17260 19769 14281 20807 23939 26405 23938 12568 12912 SIGNALING EVENTS REGULATED BY RET TYROSINE KINASE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS REGULATED BY RET TYROSINE KINASE Signaling events regulated by Ret tyrosine kinase 18750 58234 14783 14573 11848 12928 114255 384783 20662 14083 14786 19713 26413 76829 17973 14585 20416 109905 16367 15461 16476 26419 18708 20779 14784 13448 14388 327826 19353 18747 26417 218397 18706 12927 19247 19303 12912 623279 ARF6 DOWNSTREAM PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF6 DOWNSTREAM PATHWAY Arf6 downstream pathway 26417 11848 11845 21844 26413 18806 18102 18805 11840 18720 215445 19353 18793 53869 545156 EFFECTS OF BOTULINUM TOXIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EFFECTS OF BOTULINUM TOXIN Effects of Botulinum toxin 22318 20979 20614 22249 20907 20910 11435 NECTIN ADHESION PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NECTIN ADHESION PATHWAY Nectin adhesion pathway 12928 14083 18717 227377 12737 107746 58998 16416 19294 109905 58235 16456 19274 20779 18708 12385 22325 19353 17356 18596 12387 18591 18706 21894 215449 16410 12550 29875 STABILIZATION AND EXPANSION OF THE E-CADHERIN ADHERENS JUNCTION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%STABILIZATION AND EXPANSION OF THE E-CADHERIN ADHERENS JUNCTION Stabilization and expansion of the E-cadherin adherens junction 22330 11848 13636 17973 65970 18717 16001 17906 19294 12388 69697 20909 17295 233765 19877 11830 22793 15234 16582 12385 17920 210126 17356 11828 12387 22323 17309 13367 11845 11308 20336 50884 216963 76884 12550 211446 13645 13649 13836 109711 IGF1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IGF1 PATHWAY IGF1 pathway 14783 12928 384783 20662 14083 18753 16001 20416 110157 16367 12015 15461 18708 17974 14784 14694 18760 18607 22631 19246 18706 12927 19247 19303 18762 11651 22627 12929 SIGNALING EVENTS MEDIATED BY HEPATOCYTE GROWTH FACTOR RECEPTOR (C-MET)%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HEPATOCYTE GROWTH FACTOR RECEPTOR (C-MET) Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) 19271 15239 20662 16332 26413 17973 73178 19255 107746 20416 109905 110157 26396 12015 15461 16476 26419 20779 17974 17295 13653 15234 26395 18607 14388 224105 23871 11652 26417 56717 70584 11789 11845 13685 18222 13858 20404 14064 20613 58194 56513 56705 74334 226970 12550 224116 56716 271457 74370 74030 26401 19303 97998 18759 13684 11848 12928 14083 26398 18708 14784 12385 18803 19353 12387 19246 67605 18706 215449 12927 18479 19247 16211 12402 18762 11651 14389 12929 ATM PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATM PATHWAY ATM pathway 17246 12530 12532 21750 54401 19360 211651 19367 21975 17535 11350 19356 12189 12144 12122 15270 26374 225182 93765 11920 240087 50883 227525 24061 27354 13006 108138 81601 13016 70681 20184 27223 21849 TCR SIGNALING IN NAIVE CD8+ T CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TCR SIGNALING IN NAIVE CD8+ T CELLS TCR signaling in naive CD8+ T cells 240354 108723 20662 16151 19264 109905 20416 12675 14360 15461 16150 16653 18607 18176 12988 22034 15170 12042 94212 18750 22324 14784 64177 22637 18803 12487 17444 12010 12524 20866 53859 12500 12519 12502 109305 16822 54354 16818 19419 16797 18754 15007 12501 18751 12526 12525 12503 19395 18646 12402 11651 26410 18761 LPA RECEPTOR MEDIATED EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LPA RECEPTOR MEDIATED EVENTS LPA receptor mediated events 21844 56637 18806 15461 16476 20779 18760 14388 18033 18035 19697 14281 19303 13649 104110 11548 65086 11848 12928 14083 17395 18753 14688 14687 18708 14679 14673 14676 18797 14674 14672 14678 14677 14675 18803 14682 19353 14681 74769 18754 12927 17096 53978 16801 432530 15200 14702 224129 11512 11515 11514 19229 12367 14745 22051 65962 11651 17390 210044 11513 78134 104111 RXR AND RAR HETERODIMERIZATION WITH OTHER NUCLEAR RECEPTOR%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RXR AND RAR HETERODIMERIZATION WITH OTHER NUCLEAR RECEPTOR RXR and RAR heterodimerization with other nuclear receptor 17977 19013 21834 22337 19014 20787 21833 11303 19015 218772 22260 22259 20183 20186 20602 20181 19401 20182 19016 67544 19411 12043 15370 21803 21926 NOTCH SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NOTCH SIGNALING PATHWAY Notch signaling pathway 433759 59287 12234 18129 16450 103806 18222 12575 13728 13858 56309 18131 18132 56381 16449 12805 13806 99982 18011 225164 18128 270118 225182 12443 54485 27401 22632 13429 13388 50754 26965 16396 13016 16924 17150 14462 227325 53870 19208 50530 20185 13389 17869 19664 11487 21402 14357 11489 20602 16189 208117 100042305 100039623 328572 12402 18550 13386 53869 DIRECT P53 EFFECTORS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DIRECT P53 EFFECTORS Direct p53 effectors 16476 17295 15234 11789 12575 22084 18045 19211 12047 18044 18046 26374 74747 20750 18854 21802 17246 19645 22178 21981 12227 11783 12607 67941 13207 15248 26921 17350 12053 13615 59092 66214 12362 64058 14000 235281 60599 218215 12062 107986 268973 19079 71361 240672 13033 13003 100683 57913 69076 108143 110750 19252 21354 20312 18997 12454 18996 14149 66824 14775 29813 21933 12050 17685 12521 12795 13496 14534 22062 16009 12177 319801 209456 12389 13557 57748 140742 18538 15469 12450 27056 55948 20400 18861 242705 68428 16878 11910 12822 20583 59035 20586 15194 66813 21781 22059 23886 71887 11576 12028 12018 12142 382985 18787 94223 193740 20724 13555 68098 13649 12368 15182 13380 22337 17988 17210 13197 12043 12122 14102 22061 12048 328572 15375 13836 12914 17390 20683 BETA5 BETA6 BETA7 AND BETA8 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA5 BETA6 BETA7 AND BETA8 INTEGRIN CELL SURFACE INTERACTIONS Beta5 beta6 beta7 and beta8 integrin cell surface interactions 21812 13612 320910 14118 14268 16421 16401 16420 16410 16419 16007 17123 18792 22329 22370 18793 20969 POSTTRANSLATIONAL REGULATION OF ADHERENS JUNCTION STABILITY AND DISSASSEMBLY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%POSTTRANSLATIONAL REGULATION OF ADHERENS JUNCTION STABILITY AND DISSASSEMBLY Posttranslational regulation of adherens junction stability and dissassembly 14573 11487 15239 19713 21844 14585 56440 17288 16001 13430 109620 104836 12558 18212 19876 12388 15461 14360 17295 20779 14673 16480 14674 12064 12385 19353 12387 19246 11845 11350 12550 13645 15170 271457 74030 63955 20562 18102 19349 13649 16002 56805 12367 12914 17392 17393 29875 VALIDATED NUCLEAR ESTROGEN RECEPTOR ALPHA NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED NUCLEAR ESTROGEN RECEPTOR ALPHA NETWORK Validated nuclear estrogen receptor alpha network 433759 18538 12608 12675 13983 12822 55960 16476 17978 71990 114604 100041004 224903 11957 15500 12006 116870 208727 211329 11764 11614 268395 671392 13508 22192 66949 12189 268903 13982 24068 18667 78330 11737 67040 27410 23957 11785 12266 12443 22200 268527 12034 69191 67488 18002 19109 212391 17979 22433 20185 667310 17869 17128 17977 19014 20602 20850 16911 13033 18997 18996 328572 12521 ERBB1 DOWNSTREAM SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB1 DOWNSTREAM SIGNALING ErbB1 downstream signaling 12334 20544 56613 56419 13712 100040260 20662 19730 22695 26413 19060 73178 98910 227743 225870 110651 11843 67603 109880 110157 26396 17907 16706 18806 15461 16476 56378 26419 74117 76709 242687 26395 67771 68089 18607 66713 22325 13860 11909 17125 71978 26417 78757 14064 56716 271457 26401 14281 640703 18805 19052 51792 11308 23980 50884 101314 76884 73086 19252 108100 17260 20807 23939 26405 23938 29875 11867 55948 22628 100039786 12015 20779 54401 22629 13653 16653 18176 14388 22631 27371 56717 13645 13649 56044 22627 18750 20846 20848 18753 26398 18708 14784 19353 74769 18706 667739 26420 12048 18762 11651 12912 VISUAL SIGNAL TRANSDUCTION: RODS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VISUAL SIGNAL TRANSDUCTION: RODS Visual signal transduction: Rods 19892 77974 79235 225600 18587 14688 19682 14697 14685 14919 19739 14699 214111 18588 24013 243923 12788 212541 245650 14913 107477 20215 INTERNALIZATION OF ERBB1%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTERNALIZATION OF ERBB1 Internalization of ErbB1 15239 20662 14083 20416 110157 13854 15461 20779 18708 14784 16653 18176 16206 104015 74769 13858 208650 20404 66700 84092 70527 231125 58194 18706 22088 16443 24064 218038 54126 13645 216080 271457 100041766 12402 13649 13429 66105 CDC42 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CDC42 SIGNALING EVENTS CDC42 signaling events 56419 26413 21844 73178 26400 56637 109880 110157 26416 26403 15461 56378 16476 74117 20779 26419 76709 67771 68089 66713 22325 224105 13860 11909 26397 56717 26417 70584 11789 14064 56513 12550 26401 53413 18805 19417 18000 18508 22612 16886 226751 13383 15208 73341 17906 26398 26399 51789 18708 12385 19353 12387 192662 12631 18706 16885 18754 12927 18479 54126 108100 26420 404710 12402 18762 29875 11867 REGULATION OF CYTOPLASMIC AND NUCLEAR SMAD2 3 SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF CYTOPLASMIC AND NUCLEAR SMAD2 3 SIGNALING Regulation of cytoplasmic and nuclear SMAD2 3 signaling 22196 26417 218210 17126 69274 59004 17128 26413 26401 16211 640703 100039592 17127 227720 19042 227292 OSTEOPONTIN-MEDIATED EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%OSTEOPONTIN-MEDIATED EVENTS Osteopontin-mediated events 11848 17395 26413 16416 18792 12675 227753 16476 18708 26419 16202 19353 18033 18035 12505 19878 53859 19697 26417 20963 18706 16410 12927 26401 14281 57257 20750 19229 17390 18720 INTEGRINS IN ANGIOGENESIS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTEGRINS IN ANGIOGENESIS Integrins in angiogenesis 22330 26413 16367 16456 20779 22370 12815 12978 26417 18704 12831 12977 17304 30924 21813 21894 16410 12814 15519 12833 12824 19303 12828 12576 12826 20750 12832 12835 12836 12825 224020 12829 107650 12834 78560 12830 94216 11848 13612 14083 14268 16001 16416 16542 18708 19877 16202 22339 19353 14173 18706 12370 12927 19247 12402 57257 12842 12843 19229 11651 20969 NOTCH-MEDIATED HES HEY NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NOTCH-MEDIATED HES HEY NETWORK Notch-mediated HES HEY network 19664 19645 433759 17977 20848 16542 21423 14387 55927 20602 17172 11863 12393 11545 108058 11835 22160 11925 19213 103806 13555 56381 15214 17927 14460 21885 14600 14463 99982 54720 16452 14465 15213 18128 270118 225182 328572 22632 12576 12504 17863 15205 13016 12914 15251 20185 ENDOTHELINS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ENDOTHELINS Endothelins 20544 26413 58861 70086 105243 13618 18783 13616 110157 26396 83995 26416 15461 16476 20779 26419 26395 26417 14281 22068 12825 104110 18750 11848 12928 18753 13614 14680 14687 14679 14673 14676 18797 14672 18795 14678 13615 14677 14675 14682 19353 14681 18796 18754 18752 18751 12927 16452 18755 432530 224129 13617 11512 12843 11515 11514 19229 11651 210044 11513 18761 104111 CXCR4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CXCR4-MEDIATED SIGNALING EVENTS CXCR4-mediated signaling events 20847 170735 110355 14968 26385 15239 14969 64143 50778 231637 227743 19264 116733 12015 14360 20779 56085 14694 20479 18607 216869 56717 78757 12988 56716 15170 11852 19303 11853 13429 16396 94212 12767 11848 12928 14083 20846 17395 20848 22612 15162 56458 20315 22324 30955 14688 14687 18708 14679 20850 18797 14674 18795 20851 14678 14677 19353 14681 12500 12502 74769 18796 16818 12631 18706 16885 12501 215449 12927 17096 18479 16452 12503 19247 14191 14702 12143 12504 104709 19229 18762 11651 PDGFR-ALPHA SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PDGFR-ALPHA SIGNALING PATHWAY PDGFR-alpha signaling pathway 12928 12389 13712 20662 100039026 18706 16410 107746 20416 14281 20807 16476 18708 14784 16451 18803 12391 18595 435684 12929 230126 SIGNALING BY AURORA KINASES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING BY AURORA KINASES Signaling by Aurora kinases 20878 20877 REGULATION OF P38-ALPHA AND P38-BETA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF P38-ALPHA AND P38-BETA Regulation of p38-alpha and p38-beta 64143 22612 15162 26398 26416 26399 14360 63953 18218 20779 26406 19094 224105 26404 19353 18481 70686 26397 216527 66513 22034 16818 19766 17096 19252 18479 14191 12143 56044 PAR4-MEDIATED THROMBIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PAR4-MEDIATED THROMBIN SIGNALING EVENTS PAR4-mediated thrombin signaling events 11848 18796 14064 14061 17906 14688 14702 14065 14676 19877 14674 14672 14675 14682 19878 BETA2 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA2 INTEGRIN CELL SURFACE INTERACTIONS Beta2 integrin cell surface interactions 16408 16409 381924 16414 16411 99571 16007 16456 18792 15894 14723 83964 15896 385643 21947 14161 21838 78369 21810 14058 110135 18791 14131 100689 12266 19123 22329 18793 REGULATION OF NUCLEAR BETA CATENIN SIGNALING AND TARGET GENE TRANSCRIPTION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF NUCLEAR BETA CATENIN SIGNALING AND TARGET GENE TRANSCRIPTION Regulation of nuclear beta catenin signaling and target gene transcription 433759 55948 22628 100039786 20583 16476 17978 20586 54401 22629 12234 12006 22631 12326 11789 21885 12550 21752 12443 26965 13016 15182 22627 18014 17869 16842 21372 17342 21402 80334 12592 15902 17395 59024 17709 13380 77578 67087 81004 64406 14175 17928 16007 21413 14797 12590 21414 234130 11835 12387 13003 100683 72693 21886 12578 73739 16319 21416 16678 12291 73389 328572 665113 21415 16543 18741 140486 12444 17877 13544 21888 17390 20174 20997 67772 11513 99377 103573 16600 PDGFR-BETA SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PDGFR-BETA SIGNALING PATHWAY PDGFR-beta signaling pathway 13712 20662 26413 73178 98910 110651 20416 109880 110157 26396 16706 14360 15461 56378 16476 74117 26419 76709 242687 13448 26395 67771 68089 66713 22325 13860 26417 218397 20469 12988 19211 271457 14281 94212 17869 16416 19052 51792 13609 16971 26941 214384 13043 21345 60595 72930 20491 238130 18803 23988 16478 18596 19341 18591 20698 19246 69710 19106 192662 11308 50884 16818 101314 215449 76884 12927 18479 108100 20807 29875 11867 14783 19271 17973 26400 19255 55948 22628 107746 18783 109905 100039786 20779 17974 54401 22629 16653 18176 14388 22631 11350 16410 22627 18750 11848 12928 20846 20848 18753 22612 15162 13430 26398 30955 18708 14784 20850 20851 232906 17356 19353 74769 18706 18754 17096 16452 26414 26420 19247 14191 12402 12143 104709 65962 S1P4 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P4 PATHWAY S1P4 pathway 26417 94226 11848 13611 26413 14687 14679 14673 14674 14678 14677 18803 14681 GLYPICAN PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN PATHWAY Glypican pathway 14733 14734 71951 JNK SIGNALING IN THE CD4+ TCR PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%JNK SIGNALING IN THE CD4+ TCR PATHWAY JNK signaling in the CD4+ TCR pathway 12928 16822 13169 16797 18751 26398 26401 16476 26419 26409 26410 17444 12929 26411 PLK1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLK1 SIGNALING EVENTS PLK1 signaling events 77744 19046 11848 18817 12532 19052 51792 103583 12234 269582 19878 17931 71876 20843 56371 16563 12534 16319 100043703 18479 72415 107995 229841 74498 12531 13605 236930 18221 99412 228730 20878 103733 12236 19348 78177 12235 67629 67141 19324 218294 233406 72119 22390 67052 REGULATION OF CDC42 ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF CDC42 ACTIVITY Regulation of CDC42 activity 71972 109904 14163 228359 75974 319899 219140 227377 70497 17207 73341 52666 210293 29815 236915 19765 20403 18803 22325 192662 11789 216963 16443 54126 18102 57257 26934 53972 FC-EPSILON RECEPTOR I SIGNALING IN MAST CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FC-EPSILON RECEPTOR I SIGNALING IN MAST CELLS Fc-epsilon receptor I signaling in mast cells 20662 26413 16151 26400 14130 18783 20416 110157 26396 12675 18806 15461 14360 16476 26419 16150 13448 26395 224105 56743 18033 15163 18778 16428 19697 215280 26417 19012 218397 14125 19249 12229 14127 14126 20963 26401 14281 19303 14083 26398 22324 14158 13609 18708 14784 18803 20698 208650 16822 18019 16797 18706 18751 17096 19252 19247 12402 11651 14389 BETA1 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA1 INTEGRIN CELL SURFACE INTERACTIONS Beta1 integrin cell surface interactions 12822 121021 16400 16779 16780 114249 16782 16776 16777 226519 16775 18073 22370 16773 12815 213119 12520 140559 12831 21826 12475 319480 16401 16410 12814 12833 12824 16398 12828 12826 20750 16404 12832 21817 12835 22329 12836 74145 12825 16403 12829 109700 12834 16402 67374 12830 94216 16772 14118 14268 99571 16774 16412 18792 104099 241226 21825 22339 17242 21923 14161 21810 110135 12842 12843 18793 NONCANONICAL WNT SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NONCANONICAL WNT SIGNALING PATHWAY Noncanonical Wnt signaling pathway 11848 22612 26419 26564 26409 19877 19016 14367 57265 216869 19353 12322 22418 68652 18019 192176 66513 68588 13543 320790 14368 13542 208846 18099 84505 26414 26420 93687 13544 18762 14369 CXCR3-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CXCR3-MEDIATED SIGNALING EVENTS CXCR3-mediated signaling events 26413 227743 26396 110157 26416 14688 26399 14687 15461 14679 20779 18708 16653 26395 14678 14677 18607 18176 19094 14681 26397 26417 56717 78757 74769 18706 109689 56716 56744 15945 17329 12766 56066 20292 13429 14702 55985 11651 NEUROTROPHIC FACTOR-MEDIATED TRK RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NEUROTROPHIC FACTOR-MEDIATED TRK RECEPTOR SIGNALING Neurotrophic factor-mediated Trk receptor signaling 330662 20662 26413 21844 18211 17207 107746 20416 109905 140580 15461 18049 26395 16653 18176 14388 26417 218397 11350 12443 13429 83945 94275 20418 83814 100040603 56470 18759 23873 56212 17179 18412 216148 11848 18053 12928 67903 19417 20848 107971 18212 18205 18708 14784 18213 78405 12064 18803 327826 19353 18706 215449 98878 19762 19769 19247 18762 14389 12929 AURORA C SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AURORA C SIGNALING Aurora C signaling 20877 16319 CELLULAR ROLES OF ANTHRAX TOXIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CELLULAR ROLES OF ANTHRAX TOXIN Cellular roles of Anthrax toxin 26417 16173 195046 26413 18667 26400 26398 26396 26399 640703 22329 26395 21926 12362 16176 69538 71914 26397 SIGNALING EVENTS MEDIATED BY TCPTP%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY TCPTP Signaling events mediated by TCPTP 70361 16337 56469 20662 20846 20848 20852 16453 19255 16542 16412 20416 17295 18708 20779 14784 20850 16451 20851 15234 14388 22339 19341 18596 18591 19246 19106 12978 74769 12977 16334 18706 13645 16211 13649 100039592 12914 109700 INSULIN-MEDIATED GLUCOSE TRANSPORT%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INSULIN-MEDIATED GLUCOSE TRANSPORT Insulin-mediated glucose transport 16337 104215 106628 210789 56637 140491 14936 55948 20913 22628 50518 100039786 240028 20909 54401 22629 20528 22631 11652 19047 16334 640703 22318 18759 18762 11651 22627 RAS SIGNALING IN THE CD4+ TCR PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RAS SIGNALING IN THE CD4+ TCR PATHWAY Ras signaling in the CD4+ TCR pathway 18750 26417 13712 26413 18751 109880 110157 320139 14281 15461 26395 16653 18176 26410 COREGULATION OF ANDROGEN RECEPTOR ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%COREGULATION OF ANDROGEN RECEPTOR ACTIVITY Coregulation of Androgen receptor activity 110651 12571 50528 21804 232286 59035 21815 14200 17978 76804 56406 17152 15382 18477 75502 225115 18813 627557 328365 12537 72993 104263 12189 268903 56705 22596 99982 12443 22200 14375 22196 229615 59004 56469 22215 19014 21413 227753 11835 227292 12387 14228 50523 12445 84704 57908 18095 114774 215114 75273 12370 12578 56218 20807 57257 19090 19229 11651 VISUAL SIGNAL TRANSDUCTION: CONES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VISUAL SIGNAL TRANSDUCTION: CONES Visual signal transduction: Cones 19892 170735 77974 76376 12790 30952 110855 79235 14686 78600 14710 19682 14697 14919 14695 19739 24013 243923 245650 14913 107477 ALK2 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALK2 SIGNALING EVENTS ALK2 signaling events 55994 11477 12168 14225 21909 17128 110542 11705 12162 17129 17125 THROMBOXANE A2 RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%THROMBOXANE A2 RECEPTOR SIGNALING Thromboxane A2 receptor signaling 110355 170735 26416 14360 20779 15894 216869 20963 13645 13649 13429 21817 22329 18750 11848 18753 22612 15162 30955 14688 18127 26941 14673 19877 14676 14674 14672 14678 14675 19094 14682 19353 18747 18796 16818 18754 18752 18751 17096 18755 14191 14697 16801 12143 14702 104709 19214 18762 21390 11651 320129 53869 18761 19222 20339 A6B1 AND A6B4 INTEGRIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%A6B1 AND A6B4 INTEGRIN SIGNALING a6b1 and a6b4 Integrin signaling 18750 16772 12369 18858 16175 15235 12821 13867 16774 55948 22628 192897 16412 20416 13866 100039786 15461 20183 18708 17295 16779 14784 54401 20181 16780 22629 20182 16782 16776 16777 226519 16775 16773 22631 19353 18706 12550 13645 13649 16403 22627 11651 12527 19882 P38 SIGNALING MEDIATED BY MAPKAP KINASES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P38 SIGNALING MEDIATED BY MAPKAP KINASES p38 signaling mediated by MAPKAP kinases 14009 16985 21823 17164 22084 55948 22628 110157 15507 26416 102626 100039786 12531 21423 20807 54401 22629 22627 19094 22631 12912 POLO-LIKE KINASE SIGNALING EVENTS IN THE CELL CYCLE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%POLO-LIKE KINASE SIGNALING EVENTS IN THE CELL CYCLE Polo-like kinase signaling events in the cell cycle 18817 12795 20620 20873 IL4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL4-MEDIATED SIGNALING EVENTS IL4-mediated signaling events 384783 20852 14159 20416 12608 26416 16367 23871 56717 16992 12703 66596 18390 15170 20292 20375 245195 16186 11628 16453 16190 15361 16416 11846 20344 18708 14128 14784 12702 16364 13449 20850 16451 11687 12053 56468 20851 18703 16191 16164 13654 21786 547253 16153 20295 21947 16165 17864 16189 21838 18706 16452 12048 12402 17863 12842 12843 11651 20683 EPHRINB-EPHB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRINB-EPHB PATHWAY EphrinB-EPHB pathway 13641 13844 13846 13642 270190 13845 TGF-BETA RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TGF-BETA RECEPTOR SIGNALING TGF-beta receptor signaling 12389 20662 20416 26409 18607 216869 12322 71978 17126 107568 229317 17872 19045 13163 21813 13132 56513 20742 67068 21809 22601 17127 11798 218441 17131 230597 21803 83814 16396 93836 75788 14219 68010 22627 66313 21814 20901 240025 18854 19053 21812 17128 19052 14784 12005 12387 14225 68652 66513 SIGNALING MEDIATED BY P38-ALPHA AND P38-BETA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING MEDIATED BY P38-ALPHA AND P38-BETA Signaling mediated by p38-alpha and p38-beta 20544 17342 56613 100040260 17164 13714 17165 17258 17346 18783 12608 22278 14567 26416 226641 15507 102626 16691 16476 22059 19094 19225 11909 13685 13982 13198 19017 73086 17260 271457 73389 13684 12912 18126 VALIDATED TRANSCRIPTIONAL TARGETS OF AP1 FAMILY MEMBERS FRA1 AND FRA2%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TRANSCRIPTIONAL TARGETS OF AP1 FAMILY MEMBERS FRA1 AND FRA2 Validated transcriptional targets of AP1 family members Fra1 and Fra2 353170 12428 11911 22282 14284 21824 23857 17395 15368 17313 16774 192897 16477 83995 16878 18127 18792 16193 16476 13179 16478 14283 14609 18021 18019 12578 12443 328572 18018 12843 20293 17390 18793 20683 SYNDECAN-1-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-1-MEDIATED SIGNALING EVENTS Syndecan-1-mediated signaling events 17395 26413 83995 20304 53378 17295 16776 14170 15234 12215 19035 15442 12815 18747 26417 12831 12361 64654 14184 14186 12814 12833 12824 12828 12826 12842 12832 12843 12835 12836 21803 12825 12829 17393 12834 20969 12830 94216 IFN-GAMMA PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IFN-GAMMA PATHWAY IFN-gamma pathway 59004 69635 56469 20846 20848 26413 18753 19255 107746 12608 109905 26403 18708 15979 16451 26395 108058 12362 12322 16391 96979 56717 26417 18706 12703 215449 16362 16452 12323 19247 26401 328572 12402 640703 17131 12325 15978 12914 11651 16176 12929 SYNDECAN-2-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-2-MEDIATED SIGNALING EVENTS Syndecan-2-mediated signaling events 11848 16772 26413 18753 14268 16774 16412 15461 53378 15529 20779 26419 60409 57916 14170 385643 12981 12028 14694 12390 269587 18747 13844 26417 218397 12361 18015 64654 14184 14186 22350 16398 21803 12367 17390 TRAIL SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TRAIL SIGNALING PATHWAY TRAIL signaling pathway 14082 22030 26417 74769 12633 26413 16151 18706 12370 19766 26398 12675 20597 26401 22035 65111 71609 26419 18708 16150 21933 VALIDATED NUCLEAR ESTROGEN RECEPTOR BETA NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED NUCLEAR ESTROGEN RECEPTOR BETA NETWORK Validated nuclear estrogen receptor beta network 11614 22192 17977 23957 12266 13983 17978 20586 71990 22200 20587 236193 57376 18002 17979 CASPASE CASCADE IN APOPTOSIS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CASPASE CASCADE IN APOPTOSIS Caspase cascade in apoptosis 20787 71609 16668 12028 11797 26401 11798 12368 12371 670717 21937 21926 12369 14083 11820 11783 66593 227753 11545 12362 12366 22030 11796 14453 14939 101706 11459 22352 228355 20740 12043 20230 21969 12370 11857 57913 16885 19766 13368 12632 13347 12122 21418 16906 16905 18646 12367 12363 12905 16907 THROMBIN PROTEASE-ACTIVATED RECEPTOR (PAR) PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%THROMBIN PROTEASE-ACTIVATED RECEPTOR (PAR) PATHWAY Thrombin protease-activated receptor (PAR) pathway 14061 SUMOYLATION BY RANBP2 REGULATES TRANSCRIPTIONAL REPRESSION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SUMOYLATION BY RANBP2 REGULATES TRANSCRIPTIONAL REPRESSION Sumoylation by RanBP2 regulates transcriptional repression 22196 17246 56469 19384 433759 19386 208727 17344 103573 IL12-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL12-MEDIATED SIGNALING EVENTS IL12-mediated signaling events 14968 16173 14969 20852 26416 18033 11909 26397 19697 56717 192656 12703 14281 19349 15978 16176 16183 18126 20846 20848 54721 16186 18034 15284 57765 19698 12774 16159 26399 20850 14103 12010 16185 16189 16184 12500 14939 12502 23882 16818 17873 15007 12501 12526 12525 12503 16452 16177 16162 14938 16174 12504 16161 56632 16182 20303 20849 13813 16160 S1P2 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P2 PATHWAY S1P2 pathway 26417 11848 13712 26413 14739 18479 16367 26416 14281 14687 16476 26419 14679 14673 14676 14674 14672 14678 14677 14675 14682 19353 12562 14681 SPHINGOSINE 1-PHOSPHATE (S1P) PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SPHINGOSINE 1-PHOSPHATE (S1P) PATHWAY Sphingosine 1-phosphate (S1P) pathway 94226 13611 81535 17250 14739 20397 13609 14687 13610 14679 14673 14676 14674 56632 14672 14678 14677 14675 14682 20698 14681 RHOA SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RHOA SIGNALING PATHWAY RhoA signaling pathway 29857 22330 17698 11848 20544 19684 320795 109333 320271 16886 18717 105243 17906 16412 16007 26398 18806 26399 16476 26419 19877 11909 12704 18719 223701 13367 19878 26397 11459 17931 20404 14064 12631 56513 16885 19211 21894 22350 14281 20807 12576 18805 18762 18720 VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL ACTIVATION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL ACTIVATION Validated targets of C-MYC transcriptional activation 13557 22059 12028 116870 109115 67014 12151 17187 20525 72195 14732 56426 20613 433968 15525 13806 66464 15519 67065 21752 21877 18102 64602 100043349 17127 11757 27354 16828 18263 81601 15510 13665 59026 69719 170676 13684 100088 380669 13681 66942 56456 17869 15902 17395 12530 17128 15361 20425 12567 56505 67025 216185 12035 20713 68632 67154 75597 18642 14283 21429 208643 72504 22042 100683 108143 18712 328572 12444 12914 18148 20174 14534 11799 C-MYB TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%C-MYB TRANSCRIPTION FACTOR NETWORK C-MYB transcription factor network 56463 21426 18507 12606 16590 14863 12609 16841 15258 12427 19152 50701 545878 18674 15481 12571 12608 11541 17311 15461 67738 232087 11906 67972 26409 51788 19374 64050 16653 12346 16790 18176 11486 17132 17120 17217 23871 23872 22761 12978 12575 20466 12418 14460 12490 17927 18099 20481 17878 67155 17523 12443 12576 12368 15205 19055 14462 19208 21849 20185 229615 22196 17869 16842 20375 19225 22408 11796 68652 12847 66513 12043 12578 18712 12757 328572 12504 17863 12843 12914 29875 20683 CD40 CD40L SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CD40 CD40L SIGNALING CD40 CD40L signaling 17869 16453 26398 26416 30955 21939 64435 16476 18708 26419 20850 19094 18033 21947 18035 16189 53859 19697 22030 11796 74769 208650 11797 21929 22034 18706 26414 26420 26401 12048 22029 22031 104709 56196 11651 REGULATION OF RAS FAMILY ACTIVATION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RAS FAMILY ACTIVATION Regulation of Ras family activation 18750 20662 19417 16852 225870 15461 14784 16653 18176 218397 18015 19419 18754 18751 12323 19395 19418 114713 20663 74055 640703 20130 19415 18762 69601 240168 240057 16854 233046 56715 54153 ALPHAE BETA7 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHAE BETA7 INTEGRIN CELL SURFACE INTERACTIONS AlphaE beta7 integrin cell surface interactions 16407 16421 12550 IL2 SIGNALING EVENTS MEDIATED BY STAT5%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL2 SIGNALING EVENTS MEDIATED BY STAT5 IL2 signaling events mediated by STAT5 12428 17869 20662 16186 16453 20416 12571 18708 14784 20850 16451 20851 14103 16185 16184 16189 12445 13709 20371 16818 12043 16992 18706 18646 19247 12048 12444 14389 16183 20683 FOXO FAMILY SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXO FAMILY SIGNALING FoxO family signaling 12125 64143 15235 18817 55948 56458 22628 100039786 12675 26419 16150 54401 22629 93759 12053 14103 22631 12387 56484 22682 13197 104318 214897 19384 19651 27373 103236 20393 252870 54601 12359 67731 26414 26420 70425 18519 20656 328572 12566 27401 12576 93687 56044 12914 22627 11651 14377 103573 SIGNALING EVENTS MEDIATED BY HDAC CLASS II%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HDAC CLASS II Signaling events mediated by HDAC Class II 22196 110355 15183 14688 14461 56233 20602 170787 54401 15184 71458 12053 79221 22143 19727 208727 12326 14815 19384 13982 15185 14460 68558 232232 22151 17260 15519 20807 14702 19386 22627 103573 CANONICAL WNT SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CANONICAL WNT SIGNALING PATHWAY Canonical Wnt signaling pathway 214897 11789 12389 13543 56637 13542 22416 71810 26554 14367 226849 13544 72293 12005 16974 84095 12387 18719 606496 240756 P73 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P73 TRANSCRIPTION FACTOR NETWORK p73 transcription factor network 18211 55948 12571 26416 93759 23886 12028 14694 11576 12018 18749 11486 18787 56484 19697 19012 16450 12649 12575 11350 68098 22431 15214 14460 12534 12566 22601 81601 83814 16396 223752 12190 56612 21945 18854 12428 20703 12125 17869 207742 17246 14252 12448 19645 14104 16180 229933 68048 18817 226646 12237 19361 16190 14651 63958 15499 18611 268882 319618 16451 30948 22142 80707 23988 19094 18196 12366 14102 22061 328572 12235 12795 22062 20683 CIRCADIAN RHYTHM PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CIRCADIAN RHYTHM PATHWAY Circadian rhythm pathway 21853 12649 27373 18627 20893 217166 12953 18143 53610 12753 12952 18626 140858 11865 BMP RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BMP RECEPTOR SIGNALING BMP receptor signaling 69274 17128 26413 56637 26409 19042 227292 17125 12622 18121 68652 11625 244058 17872 19045 66513 12161 12167 12166 17130 23892 20481 14313 69585 12667 66042 55994 12159 12168 218441 68799 11798 17131 227720 12156 12162 75788 68010 66313 17129 ALK1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALK1 PATHWAY ALK1 pathway 11477 14225 11482 VALIDATED TRANSCRIPTIONAL TARGETS OF TAP63 ISOFORMS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TRANSCRIPTIONAL TARGETS OF TAP63 ISOFORMS Validated transcriptional targets of TAp63 isoforms 17246 14252 18753 229933 20423 68048 18817 22337 192897 100039786 12675 18104 16400 16150 12234 23886 12028 22032 13654 14027 11486 192119 64058 66993 73472 20148 21420 20724 18294 13197 107568 12575 14776 11350 17304 20833 16449 12578 14102 22061 63955 73389 328572 14149 16396 16009 20683 18854 GLUCOCORTICOID RECEPTOR REGULATORY NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLUCOCORTICOID RECEPTOR REGULATORY NETWORK Glucocorticoid receptor regulatory network 100043429 12355 433759 26413 19060 56637 16163 110308 55948 225888 18736 12991 22354 83995 14229 26416 16664 16667 16476 17978 15894 20588 26419 12569 20586 74551 22629 18514 83797 13653 22059 68094 18976 12640 12028 11576 18749 18033 19697 26417 12575 20393 16362 21374 15519 14281 18018 15978 15182 14462 19109 16183 17246 20375 20846 17977 99571 57765 16193 20850 20851 16191 12981 19094 18986 16189 14228 18747 14815 22088 15370 26414 26420 328572 12568 12914 11651 12912 20339 EPHRIN A REVERSE SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRIN A REVERSE SIGNALING Ephrin A reverse signaling 14360 13839 13640 REGULATION OF ANDROGEN RECEPTOR ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF ANDROGEN RECEPTOR ACTIVITY Regulation of Androgen receptor activity 30051 12606 217127 15408 15502 433759 52915 223870 56637 50528 26416 16476 26419 20588 59035 20779 17978 93759 13653 57376 14694 11614 68098 67155 18519 15519 81601 17246 320795 17977 56458 26398 26399 14461 20183 56233 20181 20182 11835 18986 14815 19696 328572 12914 18585 21848 110147 22026 22025 66884 BETA3 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA3 INTEGRIN CELL SURFACE INTERACTIONS Beta3 integrin cell surface interactions 13612 16399 14118 14268 99571 16542 16007 16416 16456 18792 16777 226519 16775 21825 22339 22370 18596 18591 20698 21923 20971 14161 21838 21810 110135 21813 16410 12828 12826 18613 20750 12842 16728 12843 16423 434174 15891 12829 18793 12830 20969 94216 EPHRINA-EPHA PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRINA-EPHA PATHWAY EphrinA-EPHA pathway 13841 13840 13838 13837 13836 13839 13640 13842 DEGRADATION OF BETA CATENIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DEGRADATION OF BETA CATENIN Degradation of beta catenin 104318 11789 21402 27373 13543 56637 13542 22416 26965 14367 12234 93687 12006 13544 16974 12005 12387 606496 S1P1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P1 PATHWAY S1P1 pathway 26417 11848 18796 26413 17250 16542 14687 13609 14679 14678 14677 18803 22339 19225 19353 18596 18591 20698 14681 REGULATION OF RHOA ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RHOA ACTIVITY Regulation of RhoA activity 11848 109904 16800 17207 52666 223435 22324 232906 22325 171207 213522 11856 69710 110596 234094 11855 223254 192662 106952 17925 216445 73167 56349 94190 23853 110279 11857 14570 213498 71704 69632 75547 109934 102098 13605 117600 16801 207212 72754 12576 57257 50768 53972 442801 AP-1 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AP-1 TRANSCRIPTION FACTOR NETWORK AP-1 transcription factor network 14284 23857 83995 11910 16476 13653 22059 17132 11909 23871 13982 19211 12534 14281 12443 18018 12576 15978 21803 16183 15251 12125 17869 17395 13614 16007 16477 26754 18792 16193 14461 17134 21857 11606 11770 12400 230899 14282 67405 16191 18619 12981 13406 17750 382056 14283 16478 12017 16153 12387 14609 16189 14815 11459 21823 18021 18019 13709 15007 12578 21416 19252 328572 17863 12843 20293 22051 12912 20683 AURORA A SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AURORA A SIGNALING Aurora A signaling 17246 83431 12877 66077 56637 100121 18245 218977 16475 21335 75786 22059 18035 18747 13197 12615 218397 19384 21770 12189 216963 20877 56371 320165 18479 54126 12531 20878 11651 11799 72119 INSULIN PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INSULIN PATHWAY Insulin Pathway 23921 16337 14783 12928 12389 20662 104215 106628 20411 17973 50915 107746 20416 16367 69940 15461 17974 18708 107371 14784 13448 18607 56484 19246 11652 218397 13685 20336 14064 16334 20393 18706 56513 211446 53413 19247 105504 12402 18762 18759 11651 66482 19262 RETINOIC ACID RECEPTORS-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RETINOIC ACID RECEPTORS-MEDIATED SIGNALING Retinoic acid receptors-mediated signaling 18750 19659 66671 17420 433759 12572 17977 26413 22337 15183 218772 26416 20183 17978 20602 26419 20181 19401 20182 19411 18747 26417 268903 18752 12534 18519 328572 12914 11651 17979 IL1-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL1-MEDIATED SIGNALING EVENTS IL1-mediated signaling events 73914 16181 266632 16178 17874 225471 16175 16180 66589 16151 54473 16179 26399 12675 16476 18708 26419 16150 26409 26406 12362 18033 19697 68652 66513 22034 18706 16177 93765 18759 18762 111173 16176 18412 LKB1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LKB1 SIGNALING EVENTS LKB1 signaling events 17869 17128 74343 56637 12283 227154 55948 19165 22628 70415 18612 17691 100039786 381979 20869 232944 75770 235344 54401 72149 22629 12539 70661 22059 71728 22631 66993 64930 67605 18747 56717 13728 13033 13982 22084 56716 74370 22350 15519 22627 12912 GLYPICAN 2 NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN 2 NETWORK Glypican 2 network 71951 17242 E2F TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E2F TRANSCRIPTION FACTOR NETWORK E2F transcription factor network 12606 13557 433759 242705 93759 21781 83767 19385 27374 13559 104158 13909 18787 18392 20133 104394 18968 20135 17215 13555 12580 12575 20859 56353 19646 234677 12189 50496 13361 436059 211586 12534 17865 22171 67935 18519 67155 52679 22594 225182 21877 12566 11920 12576 22632 22294 235559 209446 12447 21849 12428 17869 12369 12448 19645 12530 23834 11783 18792 15248 17210 19650 12445 19651 100683 12578 12419 73389 328572 12914 14534 22062 20683 HYPOXIC AND OXYGEN HOMEOSTASIS REGULATION OF HIF-1-ALPHA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HYPOXIC AND OXYGEN HOMEOSTASIS REGULATION OF HIF-1-ALPHA Hypoxic and oxygen homeostasis regulation of HIF-1-alpha 12578 26754 15519 56438 71745 67923 112406 216440 11863 22346 22059 14694 319594 53417 15251 56292 112407 IL23-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL23-MEDIATED SIGNALING EVENTS IL23-mediated signaling events 11686 93672 209590 16173 16171 20846 20848 54721 16193 16400 18708 12702 20850 18033 18035 19697 18706 12501 16452 17523 17329 16174 12504 16161 15978 16182 329244 20293 20849 330122 21926 257630 83430 16160 16176 16183 18126 TCR SIGNALING IN NAIVE CD4+ T CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TCR SIGNALING IN NAIVE CD4+ T CELLS TCR signaling in naive CD4+ T cells 240354 14968 108723 14969 20662 17973 16151 19264 20416 109905 12675 15461 14360 16150 16653 18176 18607 26411 16428 12988 192176 13169 22034 19211 15170 12042 94212 18750 23880 53416 22376 24055 77799 22324 14784 64177 22637 18803 12487 17444 12524 20866 53859 12500 12519 12502 109305 16822 54354 16818 19419 16797 18754 12501 18751 12503 19395 19247 12402 12504 11651 26410 14389 18761 EPO SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPO SIGNALING PATHWAY EPO signaling pathway 384783 20662 20846 21682 13857 107746 16923 20416 109905 13856 26416 15461 26419 18708 12702 14784 20850 20851 14388 18803 22325 18033 12229 12043 17096 15170 16452 19247 12048 12402 234779 12929 HIF-1-ALPHA TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HIF-1-ALPHA TRANSCRIPTION FACTOR NETWORK HIF-1-alpha transcription factor network 15368 15378 103988 16476 17978 16006 18787 23871 20525 13806 14281 21752 20893 17127 16828 100042570 15251 12767 18126 112407 15902 17977 17128 16414 13614 18671 20315 26754 13856 14151 11674 17988 72157 14461 18655 56233 22041 23959 17210 26357 11863 12870 170768 79362 11535 18641 22339 21786 230099 16846 17684 18746 13805 15275 19883 11520 15277 22042 328572 18550 12914 11651 18148 12912 20683 LPA4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LPA4-MEDIATED SIGNALING EVENTS LPA4-mediated signaling events 18747 18754 73086 14680 432530 224129 11512 11515 11514 104110 210044 11513 12912 78134 104111 NEPHRIN NEPH1 SIGNALING IN THE KIDNEY PODOCYTE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NEPHRIN NEPH1 SIGNALING IN THE KIDNEY PODOCYTE Nephrin Neph1 signaling in the kidney podocyte 12488 17973 73178 26398 14360 12015 16476 17974 18708 26419 14784 18803 216869 19353 21872 74769 170484 14064 54631 170643 18706 56513 26414 26420 22068 18762 18759 11651 ARF6 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF6 SIGNALING EVENTS Arf6 signaling events 16399 13636 17973 16416 17295 20779 14676 14672 15234 14675 216869 14682 11845 11555 212285 216963 11607 22095 232227 16867 78618 16554 216859 109689 50753 320495 13645 70676 19159 19303 231821 13649 19158 13836 PAR1-MEDIATED THROMBIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PAR1-MEDIATED THROMBIN SIGNALING EVENTS PAR1-mediated thrombin signaling events 18750 11848 320795 18753 56440 13430 14061 17906 18127 14688 14687 18708 14679 14673 19877 14676 14674 18797 22793 14672 18795 14678 14677 14675 14682 22323 19878 14681 192662 18796 14064 18706 18752 18751 109689 75547 14062 16801 13429 67804 14702 22068 320129 ALK1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALK1 SIGNALING EVENTS ALK1 signaling events 21812 12389 17128 26413 216869 15901 17125 13805 26417 14225 19045 11482 21813 55994 11477 16323 12168 21809 21909 12165 11481 17131 13001 21803 11480 17129 PRESENILIN ACTION IN NOTCH AND WNT SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PRESENILIN ACTION IN NOTCH AND WNT SIGNALING Presenilin action in Notch and Wnt signaling 17869 19664 11487 14357 100039026 433759 26413 17999 13380 56637 21405 19015 14797 16476 59287 103583 26409 12234 14362 16974 12005 12387 22408 26417 11789 21770 73016 24117 66513 13542 208117 21885 18099 100042305 19164 100039623 18128 14281 12443 13388 93687 14296 13016 93960 12914 56811 E-CADHERIN SIGNALING IN THE NASCENT ADHERENS JUNCTION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E-CADHERIN SIGNALING IN THE NASCENT ADHERENS JUNCTION E-cadherin signaling in the nascent adherens junction 16407 11848 12928 21844 16421 18717 13383 107746 109905 12388 20779 18708 16480 13043 242687 12385 22325 19353 17356 12387 21872 11845 11308 50884 18706 215449 76884 12550 12443 18102 226541 11651 29875 11767 CLASS I PI3K SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CLASS I PI3K SIGNALING EVENTS Class I PI3K signaling events 11848 16332 22612 15162 101476 109905 30955 15461 14360 20779 18708 16653 18176 18607 22637 18803 19353 56484 16428 11845 106952 74769 12229 20963 20393 16818 16797 18706 17060 19211 17096 26377 15519 19159 14191 231821 12143 234779 19158 104709 11840 19157 83436 11844 E-CADHERIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E-CADHERIN SIGNALING EVENTS E-cadherin signaling events 16480 12550 12387 CLASS IB PI3K NON-LIPID KINASE EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CLASS IB PI3K NON-LIPID KINASE EVENTS Class IB PI3K non-lipid kinase events 26413 26395 104709 18576 30955 IL27-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL27-MEDIATED SIGNALING EVENTS IL27-mediated signaling events 20847 16173 16171 20846 20848 54721 50498 57765 246779 16159 50931 16193 20850 16451 16195 16452 16162 16161 15978 21803 20849 21926 14462 16160 16176 16183 PLK2 AND PLK4 EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLK2 AND PLK4 EVENTS PLK2 and PLK4 events 20620 20873 PDGF RECEPTOR SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PDGF RECEPTOR SIGNALING NETWORK PDGF receptor signaling network 18590 71785 54635 18595 18596 18591 E-CADHERIN SIGNALING IN KERATINOCYTES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E-CADHERIN SIGNALING IN KERATINOCYTES E-cadherin signaling in keratinocytes 11652 11848 12374 18706 12550 16475 12388 14360 13649 20779 18708 16480 22793 12385 18803 11651 18720 19353 22323 12387 SIGNALING EVENTS MEDIATED BY PRL%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY PRL Signaling events mediated by PRL 12428 19352 26417 11848 19245 12575 19244 26413 56187 107503 16412 12927 11606 12566 20779 11853 19877 13653 22143 12447 109700 19353 REGULATION OF NUCLEAR SMAD2 3 SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF NUCLEAR SMAD2 3 SIGNALING Regulation of nuclear SMAD2 3 signaling 100041953 15977 12399 433759 20687 15378 15481 12608 11910 16476 17978 21815 75901 20482 14836 21781 13390 76793 226519 228839 13559 15228 18091 54123 18787 11909 94112 12705 56484 104394 14106 20467 17126 17187 12575 19646 13982 20466 17927 245688 54601 20481 18519 12579 14281 12566 17127 17131 209446 13016 15182 14462 20185 60406 229615 17869 59004 17128 17977 22337 16419 56458 21423 12567 22642 12400 12393 16191 11835 19650 16153 14815 17260 328572 12843 12914 11651 14534 12912 20683 IL2-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL2-MEDIATED SIGNALING EVENTS IL2-mediated signaling events 384783 20662 26413 17164 20416 110157 26396 26416 16367 15461 216233 14360 16476 56324 26419 22780 20844 26395 16653 18176 26417 218397 20963 12703 14281 12566 15978 16183 17869 11848 20846 20848 16186 16453 12700 18708 14784 12702 13449 20850 16451 20851 19094 16185 16184 12043 16818 18706 18754 18751 26420 19247 19229 14389 AMB2 INTEGRIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AMB2 INTEGRIN SIGNALING amb2 Integrin signaling 11848 16409 17395 15235 16414 15162 109905 18792 16193 20344 16971 15894 19877 83964 18815 18033 17882 21838 18791 215449 21894 11596 238055 20345 434174 14219 21926 17390 19882 18793 67374 SIGNALING EVENTS MEDIATED BY PTP1B%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY PTP1B Signaling events mediated by PTP1B 16337 12389 12991 20416 16367 14360 20779 13448 22166 12978 12977 12988 16847 50490 19116 12333 22608 13645 13649 19109 16399 11848 12928 20848 54721 22612 15162 16416 12558 14158 18708 12702 14784 20850 20851 64177 16846 18596 18591 19246 14131 16334 16818 18706 16797 24064 17096 12927 16452 14191 12143 11651 REGULATION OF RETINOBLASTOMA PROTEIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RETINOBLASTOMA PROTEIN Regulation of retinoblastoma protein 12606 13557 12609 433759 242705 12571 12608 110157 26416 16476 17295 20586 20587 21808 93759 14836 21781 11909 104394 18505 13433 223922 13555 12575 19660 12715 11350 270627 19646 14312 56321 12418 17927 21374 12443 12566 27401 12576 13016 12447 20937 20390 12428 17246 17342 20375 19645 15183 19052 12567 12393 19016 12981 19094 21429 12445 13709 12578 17260 26420 328572 12444 12914 CERAMIDE SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CERAMIDE SIGNALING PATHWAY Ceramide signaling pathway 17869 26413 18753 18590 26398 26396 110157 16706 12015 71609 26419 26921 26395 12028 18033 18035 19106 22030 14082 19697 11796 26417 228355 114774 13033 12043 12370 19766 12122 13645 26401 20597 56632 670717 21937 18762 26926 21926 11651 23992 67384 58994 12905 11886 CLASS I PI3K SIGNALING EVENTS MEDIATED BY AKT%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CLASS I PI3K SIGNALING EVENTS MEDIATED BY AKT Class I PI3K signaling events mediated by Akt 210789 227743 56637 55948 22628 56458 110157 12675 100039786 12015 20779 54401 22629 20528 18607 22631 606496 56484 23797 11652 18747 56717 78757 12575 54601 56716 26408 15519 12048 12576 19090 12371 16646 22627 11651 VALIDATED TRANSCRIPTIONAL TARGETS OF DELTANP63 ISOFORMS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TRANSCRIPTIONAL TARGETS OF DELTANP63 ISOFORMS Validated transcriptional targets of deltaNp63 isoforms 17246 14284 16175 12609 14104 13395 22337 56637 211323 110308 18987 55948 20913 16664 16400 14694 226849 11486 64058 12062 107568 12831 14776 17535 12578 18128 22061 15201 21973 73389 26362 22601 72433 21415 11920 12442 50754 56437 67815 15205 16396 56436 12190 20997 16009 PLK3 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLK3 SIGNALING EVENTS PLK3 signaling events 50883 22059 12447 12795 12532 INTEGRIN-LINKED KINASE SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTEGRIN-LINKED KINASE SIGNALING Integrin-linked kinase signaling 67444 225341 170736 26431 68458 64099 140579 56637 21961 73341 57342 67268 76142 18938 21335 21417 75786 16476 17974 56505 22793 12539 11545 16202 19353 12387 13367 78757 17931 20613 54126 15519 19303 12443 20878 11651 56212 20174 29875 12912 109711 103573 DOWNSTREAM SIGNALING IN NAIVE CD8+ T CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DOWNSTREAM SIGNALING IN NAIVE CD8+ T CELLS Downstream signaling in naive CD8+ T cells 13712 26413 109880 26396 110157 320139 15461 16476 26419 13653 26395 16653 18176 26417 15976 14281 18018 640703 15978 21926 16183 18750 21942 16186 16477 22163 230398 14103 15975 14283 13656 12010 16185 21936 16184 12500 14939 12502 18021 18019 18754 15007 12501 18751 12526 12525 12503 26420 18646 20849 13813 18761 LISSENCEPHALY GENE (LIS1) IN NEURONAL MIGRATION AND DEVELOPMENT%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LISSENCEPHALY GENE (LIS1) IN NEURONAL MIGRATION AND DEVELOPMENT Lissencephaly gene (LIS1) in neuronal migration and development 11848 83431 18472 100039026 22359 13131 19699 17755 23924 18476 13424 12569 27226 18475 19353 16976 13193 56430 12570 21770 11350 640703 18221 100040603 12568 22627 29875 ERBB RECEPTOR SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB RECEPTOR SIGNALING NETWORK ErbB receptor signaling network 21802 13867 18183 211323 13869 11839 13866 13645 15519 13649 15200 13874 100042150 12223 83961 EPHRIN B REVERSE SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRIN B REVERSE SIGNALING Ephrin B reverse signaling 16399 21844 22612 15162 16416 26398 14360 17974 20779 18708 26419 26409 19353 13641 13844 19249 16818 18706 50780 17096 13846 13642 270190 14191 13429 12143 P53 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P53 PATHWAY p53 pathway 15258 12450 56637 26416 26419 22059 27374 12649 11350 68098 13163 18519 26374 27401 12566 22632 11920 50883 81601 59026 18002 21849 12428 17246 18753 19052 67025 23988 110854 226830 104318 65019 214897 73251 225055 67956 27373 219022 103236 100043295 333654 12578 252870 110750 17248 13560 216080 70425 26420 67773 53892 328572 93687 12914 11651 69181 FOXA1 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXA1 TRANSCRIPTION FACTOR NETWORK FOXA1 transcription factor network 20703 20423 12608 15377 12822 16476 114604 100041004 11835 11957 22370 18986 11764 13508 15376 18095 268903 12189 16334 13982 78330 238055 14281 328572 12576 15375 72082 22287 12914 320951 14526 11819 18029 17979 18027 22433 20683 20387 667310 20390 PLASMA MEMBRANE ESTROGEN RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLASMA MEMBRANE ESTROGEN RECEPTOR SIGNALING Plasma membrane estrogen receptor signaling 17698 11848 20662 17395 16001 20416 14680 18127 14688 15461 13983 14687 18708 20779 14679 14784 14676 18797 14674 18795 14672 14678 16653 14677 14675 18176 19094 14682 14681 19878 18796 13982 18706 75273 12927 268980 14702 15200 11651 17390 ENDOGENOUS TLR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ENDOGENOUS TLR SIGNALING Endogenous TLR signaling 11848 266632 17874 12475 16151 16179 13003 12675 21899 142980 20202 17087 16150 12111 21898 24088 20201 117149 21897 15510 106759 108960 434174 20387 IL8- AND CXCR2-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL8- AND CXCR2-MEDIATED SIGNALING EVENTS IL8- and CXCR2-mediated signaling events 18750 15162 19052 30955 140580 18806 14688 51792 12765 94176 19354 14676 18797 18795 14678 14675 18607 216869 22323 18796 18752 18751 109689 17096 271457 14191 19349 12402 13429 14702 104709 11651 53869 ATF-2 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATF-2 TRANSCRIPTION FACTOR NETWORK ATF-2 transcription factor network 26413 26416 11910 63953 18218 16476 26419 21808 26914 12123 13008 18595 71355 11909 15132 81703 11423 20724 26417 12189 13982 13198 19017 14281 12443 15978 15205 81601 83430 18126 18750 12428 19645 16477 18792 16193 11846 12567 12702 12400 19094 16478 18986 13197 21823 240672 18015 16334 12043 19252 26420 12048 26554 328572 20174 17390 12912 20339 EGF RECEPTOR (ERBB1) SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EGF RECEPTOR (ERBB1) SIGNALING PATHWAY EGF receptor (ErbB1) signaling pathway 20662 14083 20846 20848 26413 17973 73178 18717 20416 15461 227753 17974 20779 14679 18708 14784 16653 14677 18176 18803 14388 19246 26417 218397 74769 18706 21894 13645 15170 18479 19247 13649 ERBB4 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB4 SIGNALING EVENTS ErbB4 signaling events 17246 12398 13385 26413 17999 211323 20416 14812 13866 14360 18708 14784 20850 13874 100042150 20851 12223 83961 80707 26417 16206 107568 68652 74769 18183 18706 13869 19116 16452 11491 22601 15200 16396 19109 20185 ANGIOPOIETIN RECEPTOR TIE2-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ANGIOPOIETIN RECEPTOR TIE2-MEDIATED SIGNALING Angiopoietin receptor Tie2-mediated signaling 12928 13712 14083 14786 69257 17973 11601 26413 50915 14268 12169 14159 14061 56458 16412 20416 26416 18806 18127 14360 18708 26419 21687 14784 20850 13449 20851 11602 18815 19353 18033 14173 23871 11600 19697 26417 218397 12575 13709 11607 18706 18479 19247 19303 21926 11651 17390 16402 CALCINEURIN-REGULATED NFAT-DEPENDENT TRANSCRIPTION IN LYMPHOCYTES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CALCINEURIN-REGULATED NFAT-DEPENDENT TRANSCRIPTION IN LYMPHOCYTES Calcineurin-regulated NFAT-dependent transcription in lymphocytes 13139 12477 17254 22778 57765 66889 16477 13655 19272 16476 12567 16364 19016 13653 16191 12981 381319 13654 14103 14283 17132 13656 19225 21947 18986 19246 16189 16184 13555 208650 18021 18019 20371 14281 18018 640703 15978 16396 12367 21926 14462 16183 18761 FOXM1 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXM1 TRANSCRIPTION FACTOR NETWORK FOXM1 transcription factor network 12428 17869 21802 19645 18817 12616 108000 14235 15379 12567 26395 16775 606496 14451 193740 12615 18021 20877 13982 12578 12534 22594 14281 12531 12443 27401 12566 328572 18005 12442 50883 54124 104156 12447 12914 12190 17390 11799 20683 IL8- AND CXCR1-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL8- AND CXCR1-MEDIATED SIGNALING EVENTS IL8- and CXCR1-mediated signaling events 18750 110355 15162 30955 14688 14676 18797 18795 14678 18607 14675 216869 18796 18754 18752 18751 17096 109689 271457 14191 12402 13429 14702 18805 227288 104709 11651 EPHB FORWARD SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHB FORWARD SIGNALING EPHB forward signaling 12928 14083 14786 26413 17973 73178 20416 109905 15461 22041 20779 18708 14784 19877 26921 16653 26395 18176 19353 13641 13844 26417 218397 104015 18706 16443 215449 13846 13642 18479 270190 13845 19303 13643 13429 20130 13640 545156 SIGNALING EVENTS MEDIATED BY HDAC CLASS I%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HDAC CLASS I Signaling events mediated by HDAC Class I 100041953 433759 64383 64384 93759 12234 27374 208727 18033 18035 22761 20467 19697 70465 17191 75387 17187 68346 21422 19646 50721 229542 234366 20466 209011 14460 245688 18519 22632 17119 17131 23942 75788 15182 21937 21926 70315 216848 229512 107932 30795 17192 60406 20185 22196 20848 15183 14461 56233 20602 170787 15184 79221 19016 18747 19384 15185 232232 328572 19386 12914 22025 103573 SIGNALING EVENTS MEDIATED BY STEM CELL FACTOR RECEPTOR (C-KIT)%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY STEM CELL FACTOR RECEPTOR (C-KIT) Signaling events mediated by Stem cell factor receptor (c-Kit) 14783 16590 20662 56637 20416 110157 26396 15461 17311 12015 20583 26419 13448 26395 18607 14388 56484 26411 26417 12703 19211 15170 240752 114715 19277 114716 17179 56792 23921 17342 20846 20848 21682 13857 16923 13856 22324 14158 18708 14784 20850 17444 12043 18706 17096 16452 19247 12402 11651 12914 12929 ALTERNATIVE NF-KAPPAB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALTERNATIVE NF-KAPPAB PATHWAY Alternative NF-kappaB pathway 53859 12234 18034 18033 19698 12675 A4B7 INTEGRIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%A4B7 INTEGRIN SIGNALING a4b7 Integrin signaling 11848 19303 14083 22329 16421 16401 16412 17123 C-MYC PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%C-MYC PATHWAY C-MYC pathway 17869 56637 19052 56505 22642 216185 226849 23988 12005 224105 109115 17187 72195 100683 12578 108143 66464 73389 27401 50754 81601 20174 14534 18854 56456 TNF RECEPTOR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TNF RECEPTOR SIGNALING PATHWAY TNF receptor signaling pathway 12389 20846 16151 26400 12675 71609 16150 26921 26409 26406 14694 22166 18033 26397 22030 14082 19697 11796 68652 228355 66513 11797 21929 67338 12370 27206 19766 399510 21938 26408 225028 18201 26412 20597 26401 665113 11491 22029 21937 20598 18762 18759 21926 74256 67384 18412 VEGF AND VEGFR SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VEGF AND VEGFR SIGNALING NETWORK VEGF and VEGFR signaling network 18186 18187 14257 22339 22341 14254 14205 16542 18654 22340 ERBB2 ERBB3 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB2 ERBB3 SIGNALING EVENTS ErbB2 ErbB3 signaling events 20662 20848 26413 13867 211323 20416 26396 110157 13866 15461 73181 12015 16476 11448 26419 18708 67588 20779 14784 67299 100042150 26395 16653 18176 19353 18747 56717 26417 74769 84092 18706 18016 26414 16452 26420 19247 14281 19056 11651 11435 FGF SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FGF SIGNALING PATHWAY FGF signaling pathway 20662 20846 17395 26413 231637 20416 12558 14182 12388 18792 15529 16476 18708 20779 14784 17967 13043 12393 14164 14170 83379 20851 14183 18607 14388 18803 327826 171463 12322 70584 26417 20111 64654 18706 14184 24064 12550 14186 19247 14281 12402 20750 19229 11651 18793 S1P5 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P5 PATHWAY S1P5 pathway 14687 11848 94226 14679 14673 14678 14677 14681 BARD1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BARD1 SIGNALING EVENTS BARD1 signaling events 18538 19361 14087 22059 67337 12021 14030 19360 211651 14088 17535 12189 72775 60534 22596 225182 12566 11920 27354 19090 235559 12447 14375 66105 22195 67030 100040608 SIGNALING EVENTS MEDIATED BY FOCAL ADHESION KINASE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY FOCAL ADHESION KINASE Signaling events mediated by focal adhesion kinase 330662 22330 12334 20662 14786 26413 17973 12169 73178 107746 109880 109905 110157 140580 14360 16476 26419 20779 17974 26395 23871 218397 21894 16410 30957 12443 19303 16402 109711 11848 12928 26431 14083 22612 16419 16412 26398 18708 14784 232906 18803 19353 20405 245671 71302 110596 19878 24000 11459 18706 215449 213498 12927 18479 54126 26420 20130 13196 HIF-2-ALPHA TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HIF-2-ALPHA TRANSCRIPTION FACTOR NETWORK HIF-2-alpha transcription factor network 13712 14297 18174 13636 11792 16341 11540 13819 18999 17387 16542 13856 18655 11863 26357 93759 22160 22339 14254 18787 17684 23871 20525 20893 67923 328572 112406 22346 12914 319594 112407 20683 GLYPICAN 1 NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN 1 NETWORK Glypican 1 network 20563 21812 11905 16772 19122 620395 22612 15162 211323 11820 14182 14360 20779 14254 22339 14173 14733 17126 21813 16818 17096 14191 21809 12143 21803 ALPHA6 BETA4 INTEGRIN-LIGAND INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA6 BETA4 INTEGRIN-LIGAND INTERACTIONS Alpha6 beta4 integrin-ligand interactions 16772 16779 16780 16782 16776 16777 226519 16403 16774 16773 192897 SIGNALING MEDIATED BY P38-GAMMA AND P38-DELTA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING MEDIATED BY P38-GAMMA AND P38-DELTA Signaling mediated by p38-gamma and p38-delta 29857 16765 12443 320795 20648 13631 65964 26415 26399 26397 HEDGEHOG SIGNALING EVENTS MEDIATED BY GLI PROTEINS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HEDGEHOG SIGNALING EVENTS MEDIATED BY GLI PROTEINS Hedgehog signaling events mediated by Gli proteins 14633 100041953 56469 433759 18753 19206 20423 56637 14688 14687 14679 103583 12234 26395 14678 14677 216869 319757 14681 269209 18747 20467 21821 104318 214897 15376 27373 103236 19646 20466 245688 70425 14702 93687 16568 15182 14634 12914 24069 11651 14632 19335 16854 211401 20747 103573 67661 60406 UROKINASE-TYPE PLASMINOGEN ACTIVATOR (UPA) AND UPAR-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%UROKINASE-TYPE PLASMINOGEN ACTIVATOR (UPA) AND UPAR-MEDIATED SIGNALING Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling 330662 12928 16409 22359 17395 16414 99571 14268 50701 16419 71785 16412 16416 14294 18792 16400 16971 20779 15234 18815 22370 19353 18787 18596 14161 110135 16410 12927 17386 14756 76701 13649 13035 14293 14289 17381 56640 21803 17392 18793 16402 REGULATION OF RAC1 ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RAC1 ACTIVITY Regulation of RAC1 activity 330662 109904 20662 19417 228359 21844 319899 219140 70497 16800 73341 52666 223435 22324 140580 19765 94176 22325 19353 13860 192662 277360 11308 24001 229877 216445 23853 110279 54126 109934 19418 57257 26934 53972 545156 IL12 SIGNALING MEDIATED BY STAT4%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL12 SIGNALING MEDIATED BY STAT4 IL12 signaling mediated by STAT4 16173 14968 14969 20848 16163 57765 16476 26419 12487 12524 16184 12500 12519 12502 16362 12501 12503 26420 18646 14281 16174 12504 15978 16182 21803 104156 20849 12914 16183 17344 HIV-1 NEF: NEGATIVE EFFECTOR OF FAS AND TNF-ALPHA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HIV-1 NEF: NEGATIVE EFFECTOR OF FAS AND TNF-ALPHA HIV-1 Nef: Negative effector of Fas and TNF-alpha 12369 12633 26400 11783 12675 71609 26419 14103 18033 18035 53859 14082 19697 22030 12366 11796 13163 12043 12370 19766 12122 12503 26408 14102 22029 12368 670717 12371 12367 21937 21926 67384 12905 WNT%NETPATH%WNT Wnt 110157 20779 12558 18751 26413 16476 26401 12550 226970 18752 26417 18753 13132 16480 56637 13542 12443 11651 26564 22408 104318 84095 22418 22413 13016 14365 93687 20664 14370 19052 12234 12005 109689 18019 18099 24117 20187 18754 20378 26419 26409 22411 19045 26563 12006 19049 16973 26398 77578 14371 18755 20377 26941 192199 14368 84035 58988 208846 212398 14369 239405 23988 72780 93897 57265 11789 14296 13380 26407 22419 22417 22421 13544 54401 13017 67943 14367 231103 320790 16971 84505 27373 22416 22420 13728 14366 20379 19353 16974 16202 20319 13543 330938 14362 22422 19016 11441 14734 18719 11848 16591 216795 22415 22412 18747 21413 21423 12387 12571 22612 16842 18761 216869 21416 606496 17125 18504 18750 EGFR1%NETPATH%EGFR1 EGFR1 208177 13548 245688 232431 394252 13836 100043257 67941 27387 12534 19303 18760 11651 18746 22038 13855 667618 628438 226250 19766 333883 29815 110355 194590 24105 209039 19727 16687 13714 26419 19272 14302 12929 16828 19246 71514 26420 108100 11674 56044 227753 14784 51789 69178 72621 109905 208650 12402 56324 13854 11461 229285 50926 22378 14360 93742 14924 17096 110157 54126 22042 20779 170643 27371 20662 286940 26396 18003 19134 18033 240752 22325 108705 218397 20848 109880 14388 18751 12566 18707 67300 14389 57257 12928 19262 12306 11431 18709 12608 19247 227937 26413 22323 26431 53378 16476 20416 26416 12912 20850 14083 73086 18648 53859 11502 15170 640703 13448 26401 17973 13449 13549 140721 11350 11308 18479 23939 72828 26411 20851 20663 13209 15239 14281 226970 24063 13196 20403 69538 18708 11855 109711 218441 16653 20499 230837 26417 22631 22324 19229 18753 230126 20846 11928 26395 232906 59026 56455 107686 71943 18803 11657 74255 26362 59079 232910 16667 13205 16480 16396 60595 98910 109904 239250 67859 101320 20439 12757 50932 24064 16668 78757 56637 29806 228136 11771 20218 68481 17886 16818 58194 234779 19248 19697 54135 13642 73379 50915 215114 23980 208643 110078 238130 13845 20970 18643 20404 17775 23943 271457 13859 171463 20969 19252 14783 19108 13016 14252 13858 71770 22687 18938 107971 229709 74055 18571 24045 105782 19211 108079 16952 20683 105787 20399 18127 321022 21894 21346 19730 14609 19084 26936 110651 17931 12388 26934 19734 21815 11820 11491 72993 19279 98432 16400 107435 53310 12631 21961 15525 26407 15382 100040260 15461 54401 13429 22330 54721 319152 12606 17979 13866 12568 16332 13867 229615 433759 19353 22352 74256 17295 13844 109620 13649 18810 17126 192897 11848 54601 17127 20112 12821 18607 30955 12927 12371 20111 26377 13685 12043 56458 13712 26400 19253 26405 606496 12988 18762 74769 20844 12703 384783 26397 19261 54473 18706 12015 18710 26406 18750 16452 16451 12702 56717 30794 226419 20617 19285 217169 75454 56205 381126 20867 29875 666899 15194 545878 12558 194655 72201 16590 12560 104831 20847 319939 11740 57783 399510 56726 73178 13628 74117 109552 667279 109135 50766 20239 15258 21881 13846 64143 223650 72391 235406 17869 22059 54132 109333 13645 23942 224650 74326 66898 13710 110308 11843 20408 19267 13835 71889 270190 20437 20910 18805 12322 208618 17920 12550 11836 20324 16337 16412 71544 13043 54366 330662 21787 17999 78388 13511 69710 18752 74155 11352 66395 67938 212139 216810 18738 67451 13132 231002 216963 110310 67760 17709 17974 225870 11949 240753 13014 22051 216190 67184 58235 19259 20195 24066 235542 18759 70527 20869 12390 327826 23938 13860 19765 18806 210126 11804 21873 16691 16706 14251 232341 18596 15259 236576 16835 20459 114479 20909 218518 76179 19707 16478 20194 140579 56460 80794 20971 330914 13838 13806 19268 66952 11746 66713 14786 12389 67097 66166 RANKL%NETPATH%RANKL RANKL 17096 22177 232790 11973 68652 18018 20586 12333 20779 18383 83433 22031 246256 22034 16151 668101 26410 66513 20375 26399 21943 12675 19698 18033 19696 11651 14200 22033 22029 104156 17342 15519 20963 16150 11909 18412 18035 15481 14389 14828 57257 11652 59029 231805 18034 22030 18709 21934 12608 108079 26413 26409 26419 105787 16476 26416 12912 14083 26420 15170 58988 208650 12402 11350 14360 18708 26417 74256 20846 26395 13649 54601 18803 13685 26400 12015 234779 16451 19697 56717 FSH%NETPATH%FSH FSH 110157 20779 319152 26396 100039786 11651 19401 14309 14772 26417 17246 13649 26395 11652 110355 109689 18747 108079 26413 13685 56458 26416 12912 216869 14609 19084 110651 14308 15507 18799 170735 20393 12640 22084 72993 26385 56484 19279 11350 667739 21817 14360 19697 56717 TSH%NETPATH%TSH TSH 110157 20779 26399 11651 20848 16150 11909 12566 18035 15481 14828 18709 16846 105782 11840 26413 14672 16952 22323 12317 12576 16001 14682 20416 20525 22094 26416 14674 12912 19049 56461 14681 19730 14083 14679 20501 14677 22095 12640 626954 667739 11792 110351 12330 21819 15461 18708 26417 67605 12567 13030 19645 12215 14678 20846 238871 11928 14673 26395 11848 18036 12445 12447 18607 18747 20111 13685 18762 12703 384783 26397 18706 18750 16452 16451 19697 12702 56717 TCR%NETPATH%TCR TCR 17096 215280 110157 22142 54126 17444 22042 16832 20779 12501 170643 192656 27371 20491 20662 12525 74039 286940 77853 26396 54167 18003 72699 19134 18033 233315 240752 50493 22388 22325 12507 108705 218397 14381 140580 11857 12500 12488 83490 12487 67300 227707 14389 104248 57257 11459 12928 20637 19262 240754 12306 101540 11431 19395 18709 320150 12608 15516 19247 21682 227937 12934 26413 12042 22323 24055 26431 20430 53378 70737 16476 73341 20416 16331 26416 12523 12912 16800 20850 19094 14083 50723 73086 545902 18648 240354 53859 13383 11502 94176 15170 74195 640703 18295 71911 13448 22376 26401 22145 17973 26558 13449 13837 13549 108723 140721 11350 77799 11308 171543 23853 18479 12477 23939 72828 107746 26411 14357 19264 20851 17829 20663 12524 16822 15239 19056 14281 56233 269378 217069 13169 20403 56444 53416 18708 77647 13367 22154 71520 72157 16438 72482 26417 13807 22631 16797 22324 242687 19229 30925 18753 12502 230126 19419 20846 14569 11928 12516 26395 14026 232906 12519 78473 18613 16428 18803 22088 13653 22165 59079 13205 16396 56637 20218 68481 12521 16818 224020 232975 234779 104112 19248 107321 19697 72349 18018 26410 100039786 12675 20963 16150 11909 18035 16453 20849 12700 18036 11744 54353 11486 22637 16923 81489 22248 17085 329693 107508 94212 54390 234374 12481 12504 19260 19384 432467 52013 14158 23880 13139 12914 15370 58231 240028 13430 12503 12469 19200 27277 98221 13548 22034 27387 12534 19303 18760 19696 11651 18746 18019 26419 12929 16828 26420 14784 109905 208650 12402 56324 14360 93742 12387 18761 IL2%NETPATH%IL2 IL2 17096 110157 20662 26396 18033 11651 20848 15519 20963 12566 11909 18707 14389 12928 18709 19247 26413 26419 16476 12929 20416 26416 12912 20850 15170 14784 20393 12402 56324 56484 667739 14360 20851 16432 23871 16453 23872 21752 16185 13684 14815 18708 16183 18795 20849 12700 22349 64685 27979 26417 22608 22324 19229 230126 20846 26395 16186 16184 17346 16168 12447 16367 30955 13685 12043 13712 18762 74769 20844 12703 384783 18706 12015 18710 16818 16452 16451 19697 12702 56717 LEPTIN%NETPATH%LEPTIN Leptin 12944 14827 110157 17977 19079 13982 20779 14432 100039026 100705 16151 17387 26396 26399 20687 108097 12675 16885 18033 12505 19696 11651 192157 17164 54611 16419 12393 20848 16370 16847 216233 16150 107476 11909 12632 18035 20528 328572 18709 19247 16846 19211 26413 18754 108079 26419 20683 16001 105787 20399 14682 20416 18127 26416 12912 20850 14083 14784 15507 667739 14360 20851 100040260 16453 13684 18708 13866 12700 12568 26417 18753 20846 26395 13649 18803 20112 16367 20111 13685 56458 13712 606496 18762 384783 56637 26397 20218 12015 69253 16818 16452 234779 16451 12702 19697 56717 IL1%NETPATH%IL1 IL1 68652 22034 16151 66513 26396 26399 12675 18033 19696 11651 20848 16150 11909 18412 18035 18709 19247 26413 26409 26419 16476 26416 26420 26398 53859 13448 18708 26417 19645 26395 18036 18803 16367 108960 30839 67857 66589 18783 16176 16179 13665 17874 16178 26400 26940 230233 26405 16177 93834 16181 18762 266632 73914 93765 20203 56637 667310 26397 67245 13666 19261 54473 66724 16175 69253 16180 26406 19697 ID%NETPATH%ID ID 110157 23872 15901 20787 26396 15902 14200 26417 17877 15904 15903 50914 19645 17928 18507 12566 13713 17927 26395 11910 19651 17878 19185 19650 17127 21406 50913 18510 21413 21423 26413 13714 66313 13712 21416 18504 15205 NOTCH%NETPATH%NOTCH Notch 20779 18033 11651 20848 18133 55927 103806 328572 56438 208117 18709 18129 18223 15182 17260 57750 26413 19165 20185 56381 54485 15208 20466 18550 11487 433586 13389 26965 66935 27401 18222 16449 100042305 16848 18132 11820 59287 11491 17305 19763 16450 21402 270118 15205 18131 14357 13388 100039623 12805 60406 20602 14533 140484 22632 14199 15214 19664 18708 19164 18128 17172 50754 26417 18519 433759 17127 21423 16396 16842 17125 56637 16818 16452 19697 TGF_BETA_RECEPTOR%NETPATH%TGF_BETA_RECEPTOR TGF_beta_Receptor 110157 20779 20662 26396 18033 12566 12928 18709 26413 16476 20416 26416 14083 73086 26411 15239 14281 18708 218441 26417 26395 59079 16396 56637 12675 16150 11909 18035 15481 71770 20683 21815 56484 23871 433759 12567 19645 17126 11848 54601 17127 12447 18607 12927 13685 56458 26397 12914 18706 56717 24136 71978 12442 66105 20742 15378 11482 76630 16416 272359 72183 15228 100041766 12399 93836 228026 52206 218210 19042 104394 17872 56513 19085 17344 56469 99152 22337 94093 75465 83814 268288 14225 20901 386655 12530 14030 12386 13207 17258 12325 17869 21808 22059 67068 13018 12189 227720 216080 17130 16211 52563 18854 20482 54709 13559 26754 21812 21417 13426 217232 12575 68999 12322 68015 21847 12323 103236 107568 76793 12705 16412 14106 103573 17128 69957 15405 22601 269338 19087 14272 21813 56317 21803 20692 11835 13132 16477 13163 108058 14282 75788 56207 59008 67903 18045 17222 20869 13542 12443 17977 13982 22034 66513 26399 12534 19303 11651 12505 12393 19052 328572 12234 12005 56438 17260 26409 26419 12006 26965 14784 21402 93742 18519 50914 11910 19651 19650 18044 21814 21413 21781 17131 12387 66313 20481 22062 16478 15529 51792 12571 18046 230597 16842 67804 21809 216869 56440 97064 17691 211586 56371 69150 75901 19877 71728 57258 18744 13805 12385 19047 20682 94112 12389 22196 18102 69260 IL4%NETPATH%IL4 IL4 20662 20375 12675 18033 11651 218397 20848 20963 16150 11909 18707 18035 14389 328572 18709 12608 19247 26413 26419 16331 20416 26416 20850 19094 14083 14784 15170 13449 12402 14360 20851 23871 16453 54721 319152 18708 12606 17979 26417 14159 12229 21939 18753 16163 20846 16164 16186 18803 16367 320129 16189 20852 13712 16190 12767 15077 12048 56468 56463 18762 20844 12703 384783 12914 18706 12015 16818 16452 234779 16451 19697 12702 ANDROGENRECEPTOR%NETPATH%ANDROGENRECEPTOR AndrogenReceptor 433759 15507 11835 68458 18708 12912 14083 11651 IL3%NETPATH%IL3 IL3 17096 110157 20779 20662 19303 100039786 18033 19401 11651 20848 20963 14388 216233 18751 11909 18707 14389 12928 19052 18709 21682 19247 26413 26419 16331 12929 20416 20525 26416 12912 56461 20850 14083 14784 15170 15507 13448 13449 12402 56484 18479 107746 14360 19264 20851 100040260 15461 54401 13429 22330 54721 18708 12700 26417 14159 22631 22324 19645 26395 12028 18747 14694 12984 14460 16188 12043 15162 56458 606496 12048 56637 14461 12015 12125 16818 18750 14127 16452 20181 16451 170741 12702 19055 ALPHA6BETA4INTEGRIN%NETPATH%ALPHA6BETA4INTEGRIN Alpha6Beta4Integrin 20779 100039786 11651 14388 18707 18709 19247 26413 16476 20416 26416 14083 14784 22629 16780 213435 16773 18208 16779 55948 16785 12367 11350 18479 23844 14360 16774 16782 16403 14281 54401 13684 18708 13866 26417 22631 19353 22352 18753 11835 17295 13844 109620 13649 18810 17126 192897 11848 17127 16367 12821 59079 30955 13685 22062 22612 74769 19882 16418 22627 12476 384783 229933 16776 20166 18706 16772 12015 18710 16777 18750 226519 56717 HEDGEHOG%NETPATH%HEDGEHOG Hedgehog 13548 11651 117606 75050 21907 70208 15245 269209 110355 19014 18747 19207 20423 14634 12387 14632 20481 13363 24069 15529 264064 20466 59024 226861 14451 19335 216869 69792 19206 17125 319757 57810 22627 12914 16147 100041953 14633 KITRECEPTOR%NETPATH%KITRECEPTOR KitReceptor 17096 215280 110157 20779 20662 26396 218397 16590 20848 18751 12566 67300 14389 12928 18709 19247 21682 26413 16476 20416 16331 26416 20850 15170 13448 22376 13449 11350 18479 20851 18708 71520 26417 14159 16797 12229 22324 20846 26395 18803 12984 15162 56468 56637 58194 234779 19697 13857 114715 19273 21933 27041 17475 22350 19349 29857 11651 23921 56792 14936 17311 17698 67296 17342 14783 11909 16197 17179 14191 328572 27261 54607 56150 19684 18019 114716 26419 12929 14784 208650 12402 56484 667739 14360 16453 15461 54353 20111 16923 13685 22612 13712 606496 12703 14158 23880 18706 12015 66713 18750 14786 16452 56717 IL-7%NETPATH%IL-7 IL-7 16453 18708 26396 16196 11651 26417 20848 19229 20846 26395 67300 16186 16197 16367 26413 20416 56458 20850 606496 20844 384783 56637 208650 56484 12015 14360 16451 20851 TNFALPHA%NETPATH%TNFALPHA TNFalpha 333654 76510 11797 56312 73174 20779 109658 14113 16709 20662 67384 21941 22628 224619 19182 18033 18567 72416 18637 19708 12539 20016 57751 14388 53376 66593 236733 22026 320795 216150 17218 19181 17463 56489 80859 18709 66413 15516 20018 19247 17906 110095 26413 56456 50797 58994 20587 16476 68094 26416 71966 16800 12912 13057 19179 20850 12633 14083 73086 76784 18037 53859 67067 16535 64424 65099 13448 70247 26401 107589 12370 18201 27207 11783 100039592 544963 18479 20017 21353 52440 226525 56710 20663 12369 18708 26417 22631 18753 20846 26395 67857 13205 16396 230233 19414 23881 23997 22123 67338 71833 69807 66724 12905 12366 56399 233406 229603 12051 12955 26403 19697 11796 16151 26410 67891 107951 100039786 12675 15519 20963 16150 18035 15481 14828 11652 18034 22030 21934 17931 22629 15507 12367 12631 231130 16648 11798 17220 54401 69721 18789 29864 227648 319152 12091 21929 22642 13866 100043714 12568 14645 103583 13867 12455 229615 15185 433759 71609 77045 54391 22166 19645 22682 21938 446099 13649 26408 20019 17126 18616 434174 56480 18036 14886 17127 26412 19173 16650 16367 14082 14229 211651 21926 12371 245841 228775 14084 21762 70834 56458 22036 57376 26400 17846 20588 26405 56532 20340 12122 18762 228355 192176 211550 56338 384783 22032 67268 66997 12914 26572 432502 76589 193740 26406 18750 56407 11647 16801 13626 21937 56717 66105 666899 100041766 228026 22059 18854 26754 68015 16477 12028 14694 12048 23938 22627 20181 68652 20586 22031 22034 100039026 66513 26399 19698 11651 19696 22033 17164 22029 19766 328572 12234 15182 18754 26419 26409 26420 26398 26965 14784 21402 50754 13728 18761 12389 22196 IL9%NETPATH%IL9 IL9 19247 16453 26413 54721 20416 18708 16199 20852 81601 26396 16198 20850 269523 11651 26417 14784 20848 384783 20846 26395 16186 16451 20851 16367 IL6%NETPATH%IL6 IL6 17096 17977 20662 26396 26399 107951 19303 18033 11651 20848 15519 14388 18035 14389 14191 328572 18709 18099 12608 21682 19247 26413 26409 26419 16476 16331 20416 26416 20850 26398 14083 14784 15507 20393 12402 56484 14360 20851 26407 15382 14281 15461 13684 54721 18708 13866 12568 16332 13867 26417 229615 14159 433759 12229 19353 22324 19229 21939 19645 18753 11835 20846 13163 26395 54601 18803 20112 21405 16195 13685 15162 56458 229317 16194 16193 12169 56637 19261 12914 12015 16452 16451 12702 IL5%NETPATH%IL5 IL5 17096 110157 20662 26396 18033 11651 23921 20848 20963 18751 11909 18035 18709 19247 26413 53378 16476 20416 12929 26416 20850 14784 15170 12402 56484 107746 20851 15461 16185 18708 26417 22631 22324 12229 19229 18753 20846 12028 14694 30955 12984 16191 12387 20677 15163 18783 20111 16192 216148 22248 11689 15162 13712 606496 12703 56637 13430 16452 16451 TSLP%NETPATH%TSLP TSLP 17096 215280 20779 16416 26396 18033 233315 20848 218210 14389 21682 19247 26413 22323 20416 12523 26416 20850 94176 15170 640703 13449 20851 71648 66870 109032 70238 75007 18000 20403 13169 54204 218236 69207 223922 18430 67010 57914 75735 195018 26417 66645 14159 628161 20868 12229 16905 227634 15896 20846 215690 101706 16477 109115 26395 71435 58234 74320 22589 23856 68298 67772 18826 12984 15162 20852 16818 14127 19697 107829 53603 76464 27049 665775 93966 21763 24116 106512 67891 78781 68925 26414 19698 29857 233724 11651 56376 20352 76499 68813 75547 15519 66314 52276 11909 57261 12649 18035 16197 18034 56370 277250 27360 15161 26419 217980 102693 80912 69719 18458 321022 16765 21894 217342 21346 17345 26420 19820 238330 26936 67959 19989 17931 23989 12388 71722 100017 208795 16906 22404 74343 76497 229542 56484 75956 74094 667739 320139 67154 226747 14360 240087 11518 13684 20849 17979 16332 18810 54353 26377 13685 22612 107508 19253 228355 18706 16452 16451 BCR%NETPATH%BCR BCR 17096 110157 20662 26396 18003 72699 18033 22325 12507 218397 20848 109880 14388 18751 83490 12566 18707 14389 12928 18709 21682 19247 12042 26413 24055 22323 16476 16331 20416 26416 12912 14083 240354 15170 13448 22376 17973 108723 77799 107746 26411 19264 20663 12369 16822 14281 56233 13169 18708 16438 26417 22324 12229 19229 18753 20846 16477 26395 14282 16428 18803 12028 15163 15162 56637 12125 16818 234779 19697 16151 12675 18760 19696 11651 23921 56792 17164 12572 20963 12520 16150 11909 18035 225724 12143 18717 27261 77590 240168 20303 18019 12902 17060 18754 26409 26419 12929 26420 14784 208650 12402 56484 12367 667739 14360 12567 19645 18719 14886 12445 12447 18718 18607 18720 30955 16439 12927 56743 12387 22637 12371 76108 20111 18021 26377 381290 13685 66922 12043 56458 12571 83436 13712 12053 12483 19253 18761 68119 12517 108083 606496 12478 12988 12518 117150 21432 101476 15387 15184 12428 14130 208154 242248 670717 12444 13430 15985 GABA-B_RECEPTOR_II_SIGNALING%PANTHER PATHWAY%P05731 GABA-B_receptor_II_signaling 12286 12287 210044 14710 66066 14704 14677 104110 19084 11514 11512 11515 18747 18749 432530 14709 54393 12291 224129 19085 19087 14679 14688 19088 14681 14693 14695 16519 14706 14708 11513 14696 242425 DNA REPLICATION%PANTHER PATHWAY%P00017 DNA replication 21974 21969 327762 18972 15081 319152 18971 18968 72151 106344 19718 21973 69263 19075 19687 19819 18538 19891 PRPP BIOSYNTHESIS%PANTHER PATHWAY%P02760 PRPP biosynthesis NICOTINE PHARMACODYNAMICS PATHWAY%PANTHER PATHWAY%P06587 Nicotine pharmacodynamics pathway 210044 14677 209195 18747 11444 110834 11440 12288 108015 11438 108043 214084 16527 14702 12291 110835 21823 13195 269587 223604 13822 13489 192176 19049 13491 19045 14688 CYTOSKELETAL REGULATION BY RHO GTPASE%PANTHER PATHWAY%P00016 Cytoskeletal regulation by Rho GTPase 17886 11465 11867 11464 17888 140781 67951 11475 22154 17880 77579 11853 17883 213435 17885 17882 17884 56443 241656 19878 19877 70584 11459 11461 56378 667663 67771 22323 19353 68089 238880 16801 19354 69581 73710 18645 18481 214230 18643 76709 224105 100042651 16885 107589 12632 56471 75477 12631 231637 73167 54004 545486 544791 13367 71960 16765 227613 18479 22153 73178 228359 22152 228785 329421 22151 17879 VITAMIN B6 BIOSYNTHESIS%PANTHER PATHWAY%P02786 Vitamin B6 biosynthesis HISTAMINE SYNTHESIS%PANTHER PATHWAY%P04387 Histamine synthesis 15186 ALLANTOIN DEGRADATION%PANTHER PATHWAY%P02725 Allantoin degradation 94041 HETEROTRIMERIC G-PROTEIN SIGNALING PATHWAY-GI ALPHA AND GS ALPHA MEDIATED PATHWAY%PANTHER PATHWAY%P00026 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway 108069 76123 268934 210044 14823 14710 14704 14677 104110 14936 19084 232493 11514 68961 11512 18682 11515 78284 18747 56637 18749 108073 432530 99296 14709 224129 19085 19087 14679 14688 19088 14693 16519 14706 14708 11513 14702 13489 13491 640703 14678 14701 15550 19735 15557 14700 15551 15552 15560 15558 15559 104111 14680 15562 18390 18386 11554 11555 11556 11553 14765 13492 12669 14773 24013 67839 20606 12672 108068 20609 56470 13488 110078 20608 64214 11552 110095 19309 110094 26427 102093 11549 20605 243764 11548 20607 11550 208647 12671 19737 56533 12913 225192 67792 213788 15563 15466 18387 51791 18389 50782 109905 215449 50778 19739 244701 17773 328572 11540 11539 15566 11541 67300 74325 15465 11542 606496 15565 16521 16522 26385 320129 12757 19736 50780 16524 12914 108071 14715 19734 110355 14772 14816 12912 50779 18679 14699 24012 71729 67865 246709 208677 AMINOBUTYRATE DEGRADATION%PANTHER PATHWAY%P02726 Aminobutyrate degradation 268860 MRNA SPLICING%PANTHER PATHWAY%P00058 mRNA splicing 22184 53607 66585 20639 70767 SCW_SIGNALING_PATHWAY%PANTHER PATHWAY%P06216 SCW_signaling_pathway CIRCADIAN CLOCK SYSTEM%PANTHER PATHWAY%P00015 Circadian clock system 27373 11865 12753 18628 18627 12953 12952 104318 18626 P53 PATHWAY FEEDBACK LOOPS 2%PANTHER PATHWAY%P04398 p53 pathway feedback loops 2 19645 11920 234129 18706 26415 12387 19053 16653 18607 19052 18705 17869 12566 29857 12428 26416 19650 23797 22059 225326 18704 12447 240752 12575 11651 20437 22061 18708 15461 320207 22062 30955 74769 18707 18176 12427 11652 12450 19211 18710 19094 18709 5HT1 TYPE RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04373 5HT1 type receptor mediated signaling pathway 15567 67474 210044 22319 14710 66066 22317 14704 22318 14677 20908 19108 20619 20614 14697 18747 18749 14709 16527 14702 14678 14701 223604 15550 15557 14700 15551 15552 19087 14679 14688 19088 14681 14693 14695 14706 14708 11513 14696 COENZYME A BIOSYNTHESIS%PANTHER PATHWAY%P02736 Coenzyme A biosynthesis 269614 74450 106564 75735 68087 211347 5HT4 TYPE RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04376 5HT4 type receptor mediated signaling pathway 15567 210044 67474 14710 22319 22317 14704 22318 20908 20619 20614 14697 14709 214084 16527 14702 110877 14701 223604 22320 14700 14680 15562 14688 14693 14695 14706 14708 11513 14696 ANGIOGENESIS%PANTHER PATHWAY%P00005 Angiogenesis 56637 12387 26416 23797 225326 18704 240752 11651 18708 15461 30955 74769 18707 18176 11652 18710 18709 18706 102626 109270 20779 78390 13837 12954 22422 14362 22414 18762 20378 17974 18481 22339 216148 234779 21687 224105 232889 18750 21414 14281 18751 23871 19263 50915 20662 73167 11789 13389 12928 16449 18755 20416 18759 18479 71785 18752 18591 228359 18753 110157 18803 19303 18754 18590 15507 16450 14066 109880 14068 20698 27371 18596 13448 11600 20377 26398 11853 13449 12005 107971 54635 71520 101540 18760 11848 13642 18783 18595 54485 26419 23805 26401 14083 26395 16542 14182 75292 11601 14062 20846 15251 11852 270190 14164 13845 26396 18127 218397 107321 20848 16476 327826 11799 27261 14786 13386 18806 18761 12929 21804 11836 17164 13844 13641 12955 20663 18805 12371 56632 22413 18129 21416 22418 22421 22408 22409 16451 26413 13388 19668 14367 26417 57265 18132 19664 22419 22410 13544 13543 14365 13542 18128 LEUCINE BIOSYNTHESIS%PANTHER PATHWAY%P02749 Leucine biosynthesis 12036 12035 INTEGRIN SIGNALLING PATHWAY%PANTHER PATHWAY%P00034 Integrin signalling pathway 12816 19229 12814 12988 23928 16419 50772 12813 12829 12828 16420 217378 16777 330662 22330 72065 12843 12817 12815 11472 225341 16779 226519 16780 26414 16414 16400 16401 26397 16782 16411 12825 16776 192897 170736 12827 223272 12826 26420 12842 16398 109700 225326 16403 18704 12389 240752 19248 12945 109711 60595 213119 18708 16774 15461 373864 241226 12840 30955 107581 74769 16773 18707 12841 18176 12819 320910 74194 71302 74012 18710 76108 223881 18709 286940 11461 56378 67771 22323 19353 238880 19354 18706 26415 20779 192176 76709 20662 16412 12818 26407 12928 26408 20416 20130 12833 12834 16408 110157 12927 12835 19303 16410 16421 11465 11867 109880 11853 26398 56443 11848 26419 14083 26395 11852 26396 12929 11836 20663 140580 21894 16407 381924 13196 329941 12837 53867 228998 12821 16772 16399 78514 11858 16202 107746 11840 14268 104099 57342 16402 12831 26406 12839 109905 215449 319480 12830 94216 12832 140579 16409 12824 16404 14360 74192 11845 57764 26405 104303 73368 26417 CORTOCOTROPIN RELEASING FACTOR RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04380 Cortocotropin releasing factor receptor signaling pathway 67474 14710 22319 22317 14704 22318 20908 20619 20614 14697 14709 14702 14701 22320 14700 14680 14672 12921 12918 14688 14675 14682 12922 18976 14693 14695 14706 14708 14696 GENERAL TRANSCRIPTION BY RNA POLYMERASE I%PANTHER PATHWAY%P00022 General transcription by RNA polymerase I 20017 19183 22130 21374 63856 21429 19285 20018 237336 21341 227606 106298 17749 21340 21339 TGF-BETA SIGNALING PATHWAY%PANTHER PATHWAY%P00052 TGF-beta signaling pathway 12156 17131 12162 20482 17130 21809 12160 320202 11909 16478 16477 26414 26419 55994 14562 21892 29857 12159 13590 26416 24087 26420 21812 110075 14226 12161 14225 14561 14563 16476 17125 68010 12163 17129 12166 12154 15461 12167 11482 242316 230597 12168 269275 18176 11479 110542 11477 21813 21808 11481 19094 11480 17127 14566 75788 14573 17128 12705 17700 12165 14227 66313 66513 17126 319618 14560 23886 26415 16326 16323 12153 14106 238057 18119 218441 26409 16325 17684 12155 16324 76793 328572 20481 14283 12914 26413 26417 20130 UBIQUITIN PROTEASOME PATHWAY%PANTHER PATHWAY%P00060 Ubiquitin proteasome pathway 75788 93765 66313 74153 24102 23996 22195 17463 19185 620934 23997 22201 22209 70247 74244 56791 56459 100763 100039535 67196 59029 21762 68612 22210 22215 66894 107568 17246 100041484 67128 70620 216080 16396 53323 22200 22194 66105 117146 218793 22193 50995 231380 100041766 22213 SYNAPTIC_VESICLE_TRAFFICKING%PANTHER PATHWAY%P05734 Synaptic_vesicle_trafficking 20907 53420 20980 70450 54524 22317 20979 18195 20614 56216 171180 229521 20910 208898 19339 20981 22249 319508 54525 13852 ASCORBATE DEGRADATION%PANTHER PATHWAY%P02729 Ascorbate degradation 66646 PHENYLETHYLAMINE DEGRADATION%PANTHER PATHWAY%P02766 Phenylethylamine degradation 237940 11754 76507 VASOPRESSIN SYNTHESIS%PANTHER PATHWAY%P04395 Vasopressin synthesis 12876 18484 19072 213760 66624 66286 76687 18429 56529 11998 212114 MUSCARINIC ACETYLCHOLINE RECEPTOR 1 AND 3 SIGNALING PATHWAY%PANTHER PATHWAY%P00042 Muscarinic acetylcholine receptor 1 and 3 signaling pathway 14710 66066 14704 14709 14700 14810 14812 14811 14814 14813 16439 18798 12669 14688 18761 14693 14695 14706 14708 14696 20907 67474 22319 22317 22318 20619 20614 12671 14697 16438 16440 20508 12647 63993 12038 22320 263803 11423 320795 109333 18762 18750 14672 18751 56216 18755 14675 14682 18759 18752 18753 18754 CARNITINE METABOLISM%PANTHER PATHWAY%P02733 Carnitine metabolism 192136 METHYLCITRATE CYCLE%PANTHER PATHWAY%P02754 Methylcitrate cycle 11428 64602 TRIACYLGLYCEROL METABOLISM%PANTHER PATHWAY%P02782 Triacylglycerol metabolism 15450 16890 SALVAGE PYRIMIDINE DEOXYRIBONUCLEOTIDES%PANTHER PATHWAY%P02774 Salvage pyrimidine deoxyribonucleotides 72269 66757 21877 ANANDAMIDE_DEGRADATION%PANTHER PATHWAY%P05728 Anandamide_degradation 14073 PENTOSE PHOSPHATE PATHWAY%PANTHER PATHWAY%P02762 Pentose phosphate pathway 21351 216019 21881 19895 15275 110208 14751 15277 GLYCOLYSIS%PANTHER PATHWAY%P00024 Glycolysis 18746 13807 56012 12183 13806 100043349 18770 18641 21991 18655 18642 11674 216019 15275 14751 15277 ADRENALINE AND NORADRENALINE BIOSYNTHESIS%PANTHER PATHWAY%P00001 Adrenaline and noradrenaline biosynthesis 381884 20538 67474 22598 74338 18113 22317 22318 109731 18948 13162 20619 20614 17161 214084 229706 21823 13195 110877 102680 100226 21743 53612 13166 103098 12846 53331 PLASMINOGEN ACTIVATING CASCADE%PANTHER PATHWAY%P00050 Plasminogen activating cascade 110135 18791 56373 18787 14161 99571 18815 18788 17392 17395 18816 83995 18793 18792 17386 O-ANTIGEN BIOSYNTHESIS%PANTHER PATHWAY%P02757 O-antigen biosynthesis 76355 14583 14584 HEME BIOSYNTHESIS%PANTHER PATHWAY%P02746 Heme biosynthesis 14151 17025 15288 70383 237926 12892 22275 67417 97541 19044 107508 ANDROGEN ESTROGENE PROGESTERONE BIOSYNTHESIS%PANTHER PATHWAY%P02727 Androgen estrogene progesterone biosynthesis 223920 15490 20652 16889 15486 15487 13075 15485 27400 HUNTINGTON DISEASE%PANTHER PATHWAY%P00029 Huntington disease 100043349 26420 23797 22059 14810 14812 14811 14814 14813 11651 22061 22062 11652 11461 14447 320982 11861 67771 228980 13191 19353 110082 106869 238880 104215 15114 20408 19354 11844 73916 14805 432611 13417 54152 11772 268958 12333 29816 12064 23830 12334 100042162 13424 13427 68097 13426 545156 381917 20683 11771 73710 21374 100042651 14281 545486 14806 73647 227613 80837 14807 22153 73178 22152 22151 11465 11867 11464 67951 11475 22154 26398 56443 11459 16476 71648 12337 12367 26400 66713 12370 11783 235661 12339 76884 56212 234663 56455 20430 12338 11840 15194 66445 14809 23969 17274 269881 76932 215114 104015 12335 11843 110637 100038842 110350 328572 11842 13385 74325 74192 11845 104303 12914 ARGININE BIOSYNTHESIS%PANTHER PATHWAY%P02728 Arginine biosynthesis 69719 227231 11898 18416 217214 109900 NOTCH SIGNALING PATHWAY%PANTHER PATHWAY%P00045 Notch signaling pathway 16450 54485 18129 20602 103806 216860 140887 18131 11491 18011 16924 50754 415115 13389 16848 13386 19668 17305 16449 140484 66935 18222 18132 53618 19664 59287 11487 19164 18128 SUCCINATE TO PROPRIONATE CONVERSION%PANTHER PATHWAY%P02777 Succinate to proprionate conversion 66904 17850 52665 BUPROPION_DEGRADATION%PANTHER PATHWAY%P05729 Bupropion_degradation 13088 PYRUVATE METABOLISM%PANTHER PATHWAY%P02772 Pyruvate metabolism 18770 69634 12974 104112 17436 18746 18534 18597 18563 18598 DE NOVO PYRIMIDINE DEOXYRIBONUCLEOTIDE BIOSYNTHESIS%PANTHER PATHWAY%P02739 De novo pyrimidine deoxyribonucleotide biosynthesis 56520 382985 20133 66757 110074 20135 79059 18102 21915 433968 22171 114873 AXON GUIDANCE MEDIATED BY SLIT ROBO%PANTHER PATHWAY%P00008 Axon guidance mediated by Slit Robo 18209 19353 11350 13176 18208 20563 19354 19876 11853 20564 57764 12767 20315 80883 20562 117600 P53 PATHWAY%PANTHER PATHWAY%P00059 p53 pathway 23882 13197 433759 12532 22030 11920 234129 18706 19053 18607 19052 328572 12566 17246 23797 22059 12447 12575 11651 22427 100043429 12914 22061 18519 20610 55948 100043858 22062 29870 12534 23942 12578 17873 11652 20466 18854 19211 50883 434174 93759 17248 5HT2 TYPE RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04374 5HT2 type receptor mediated signaling pathway 15567 14710 66066 14704 14697 14709 214084 16527 14702 110877 223604 14701 14700 18762 15560 15558 15559 234779 74055 14672 18750 18799 114875 18751 18802 18796 18797 18795 18798 14688 18755 14675 18761 14682 18759 14693 18752 14695 18753 14706 14708 18803 14696 18754 T CELL ACTIVATION%PANTHER PATHWAY%P00053 T cell activation 109880 12988 26419 640703 26401 26395 12502 17444 12675 19264 22325 19056 26420 19055 57257 23797 26396 225326 16476 11651 18708 15461 18761 30955 74769 18707 11836 18176 11652 20663 18710 18709 19353 18706 12503 16797 12501 12500 12519 19057 16438 22376 16822 12524 22637 22324 12487 16150 16818 18035 18481 17974 224105 14281 20662 26413 26417 18479 110157 18803 PROLINE BIOSYNTHESIS%PANTHER PATHWAY%P02768 Proline biosynthesis MUSCARINIC ACETYLCHOLINE RECEPTOR 2 AND 4 SIGNALING PATHWAY%PANTHER PATHWAY%P00043 Muscarinic acetylcholine receptor 2 and 4 signaling pathway 14710 66066 14704 14677 19084 18747 18749 14709 19085 14678 14700 19087 14679 14688 19088 12672 14681 14693 14695 16519 14706 14708 14696 20909 20907 102857 67474 74732 22319 68159 22317 14685 271639 243764 22318 228960 19108 20619 20614 14697 20508 12647 63993 12038 22320 11423 14686 16521 16522 16524 56216 FORMYLTETRAHYDROFORMATE BIOSYNTHESIS%PANTHER PATHWAY%P02743 Formyltetrahydroformate biosynthesis 13361 17768 238505 270685 22171 GLUTAMINE GLUTAMATE CONVERSION%PANTHER PATHWAY%P02745 Glutamine glutamate conversion 266744 14661 14645 METABOTROPIC GLUTAMATE RECEPTOR GROUP I PATHWAY%PANTHER PATHWAY%P00041 Metabotropic glutamate receptor group I pathway 19108 14672 19084 14810 14812 18751 14811 14805 18747 14814 14813 18749 66168 18798 26556 108071 14809 14676 14682 14816 16438 19085 METHIONINE BIOSYNTHESIS%PANTHER PATHWAY%P02753 Methionine biosynthesis 238505 ADENINE AND HYPOXANTHINE SALVAGE PATHWAY%PANTHER PATHWAY%P02723 Adenine and hypoxanthine salvage pathway 15452 18950 11821 22436 11486 ANGIOTENSIN_II-STIMULATED_SIGNALING_THROUGH_G_PROTEINS_AND_BETA-ARRESTIN%PANTHER PATHWAY%P05911 Angiotensin_II-stimulated_signaling_through_G_proteins_and_beta-arrestin 14710 66066 14704 14697 14709 16438 16440 26395 14700 18750 26396 26385 320129 18796 18797 16439 18795 14773 26413 14688 110355 216869 26417 11606 14682 13653 14693 13712 14695 109689 11607 110157 14706 14708 14696 5-HYDROXYTRYPTAMINE DEGREDATION%PANTHER PATHWAY%P04372 5-Hydroxytryptamine degredation 72535 14204 11668 56752 216188 56847 109731 11669 107747 110695 11670 17161 237320 11671 19378 69748 212647 P53 PATHWAY BY GLUCOSE DEPRIVATION%PANTHER PATHWAY%P04397 p53 pathway by glucose deprivation 23797 22059 64930 19079 105787 11651 22084 108079 58988 22061 13685 19053 20869 22062 18518 19082 19052 108097 11652 ALZHEIMER DISEASE-AMYLOID SECRETASE PATHWAY%PANTHER PATHWAY%P00003 Alzheimer disease-amyloid secretase pathway 57267 11441 12289 232943 23939 74764 50772 11820 100042305 18549 225724 12295 332110 56175 11502 18551 12296 18553 208117 16593 26419 26414 23821 18548 81601 18550 19165 11784 319924 29857 26416 26420 12669 18761 16594 54652 12672 18554 12292 19094 243764 12671 26415 12288 213788 263803 320795 109333 18762 18750 18751 11491 26413 18755 26417 18759 18752 18753 59287 11487 18754 19164 GENERAL TRANSCRIPTION REGULATION%PANTHER PATHWAY%P00023 General transcription regulation 228980 69833 319944 22130 72308 83602 63856 407786 71828 14885 245841 14884 237336 68705 21341 98053 68153 21343 66464 229906 14894 68776 74197 209357 20021 66653 24074 108143 235459 74238 VALINE BIOSYNTHESIS%PANTHER PATHWAY%P02785 Valine biosynthesis 12036 12035 216136 GBB_SIGNALING_PATHWAY%PANTHER PATHWAY%P06214 GBB_signaling_pathway COBALAMIN BIOSYNTHESIS%PANTHER PATHWAY%P02735 Cobalamin biosynthesis DPP-SCW_SIGNALING_PATHWAY%PANTHER PATHWAY%P06212 DPP-SCW_signaling_pathway GASTRIN_CCK2R_240212%PANTHER PATHWAY%P06959 Gastrin_CCK2R_240212 19229 12988 23939 18747 56637 18749 432530 27373 13685 12387 18607 26414 104318 26416 26420 17096 20111 11651 17392 18708 14688 18792 74769 19211 19353 20779 214084 14702 20683 18035 18750 14281 18751 20662 16412 12928 18755 216869 20416 18479 13653 13712 18753 110157 12927 18803 19303 16410 18754 15507 109880 26398 11909 12426 101540 18760 11848 19877 18783 640703 26419 14083 26395 19735 19055 26396 20848 16476 18761 11836 14459 19016 16600 12367 11773 110651 13429 12494 26399 55984 16367 14784 194231 667739 19091 12015 20191 12876 12028 18125 22021 18573 19225 22026 16438 16452 22612 18019 56484 20687 23938 21413 20192 11640 17259 18263 19247 20807 171207 56458 20190 14919 67605 26403 12048 12043 22034 15568 233979 54401 12326 12759 17261 26413 252972 13714 53859 13684 26417 20613 12424 12912 17283 93687 15200 110596 56233 12550 17260 15937 PYRIDOXAL PHOSPHATE SALVAGE PATHWAY%PANTHER PATHWAY%P02770 Pyridoxal phosphate salvage pathway 216134 103711 HETEROTRIMERIC G-PROTEIN SIGNALING PATHWAY-GQ ALPHA AND GO ALPHA MEDIATED PATHWAY%PANTHER PATHWAY%P00027 Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway 108069 12286 76123 12287 268934 14823 14710 14704 217378 108073 14709 16439 18798 14688 14681 14693 14695 16519 14706 14708 14696 16801 14702 13489 13491 18762 18750 14672 18751 14676 14675 18755 14682 18759 18752 18753 18754 12061 110351 233046 99326 19419 12062 240168 64337 93690 12290 19395 11848 14701 19735 14700 18390 18386 18796 18797 18795 13492 12669 14773 67839 20606 18761 12672 108068 20609 56470 13488 20608 64214 20605 243764 20607 12671 19737 56533 67792 213788 18387 51791 18389 16438 50782 16440 109905 215449 50778 19739 11540 11539 11541 67300 74325 11542 16521 16522 26385 320129 12757 19736 50780 16524 108071 14715 19734 110355 14772 14816 50779 14699 24012 71729 67865 246709 IONOTROPIC GLUTAMATE RECEPTOR PATHWAY%PANTHER PATHWAY%P00037 Ionotropic glutamate receptor pathway 108069 108058 12322 74732 67474 68159 22319 22317 22318 18195 20619 20614 14805 12323 243961 20510 14809 20511 53623 14802 216227 12300 242607 14800 20512 110637 22320 14799 20513 140919 18693 58234 14810 14812 14811 140723 14814 14813 14806 108068 14807 MANNOSE METABOLISM%PANTHER PATHWAY%P02752 Mannose metabolism 218138 69080 29858 54128 110119 331026 INSULIN IGF PATHWAY-PROTEIN KINASE B SIGNALING CASCADE%PANTHER PATHWAY%P00033 Insulin IGF pathway-protein kinase B signaling cascade 16001 16002 16000 16004 56458 17246 16370 23920 16337 606496 16334 16367 64930 384783 234129 56637 18706 22084 18607 56484 19211 16332 17248 JAK STAT SIGNALING PATHWAY%PANTHER PATHWAY%P00038 JAK STAT signaling pathway 20846 19264 26416 20848 16451 17344 20850 16452 20851 229615 12703 20852 20849 56469 16453 MYO_SIGNALING_PATHWAY%PANTHER PATHWAY%P06215 MYO_signaling_pathway TRYPTOPHAN BIOSYNTHESIS%PANTHER PATHWAY%P02783 Tryptophan biosynthesis XANTHINE AND GUANINE SALVAGE PATHWAY%PANTHER PATHWAY%P02788 Xanthine and guanine salvage pathway 15452 18950 14544 ORNITHINE DEGRADATION%PANTHER PATHWAY%P02758 Ornithine degradation 18263 242669 54375 FRUCTOSE GALACTOSE METABOLISM%PANTHER PATHWAY%P02744 Fructose galactose metabolism 74246 16548 230163 14430 11676 11674 216019 15275 15277 P38 MAPK PATHWAY%PANTHER PATHWAY%P05918 p38 MAPK pathway 15507 63953 13197 19252 68652 100040260 16177 17346 26399 13631 73086 66513 56613 17347 26398 26415 102626 269881 26409 17259 20807 29857 26416 22034 17261 26407 26408 13684 17164 13712 17260 19094 LYSINE BIOSYNTHESIS%PANTHER PATHWAY%P02751 Lysine biosynthesis HISTIDINE BIOSYNTHESIS%PANTHER PATHWAY%P02747 Histidine biosynthesis WNT SIGNALING PATHWAY%PANTHER PATHWAY%P00057 Wnt signaling pathway 14704 14709 14688 14693 14695 14706 14708 14696 17128 19057 14702 26409 14672 14676 216869 14675 14682 109689 433759 20377 12005 19056 19055 18796 18797 18795 18761 21770 26931 26932 226849 225849 18018 70425 103236 14368 14371 14369 16842 16974 12560 16973 14366 22412 20890 216795 14370 67155 22417 93761 68094 20439 20588 20586 20587 22420 22413 68911 21372 21416 72135 22418 22421 66993 22408 70315 93760 22409 22415 57376 93960 12385 22423 241201 21888 12564 21885 84035 12552 21887 73173 14367 20319 216033 57265 93881 93704 20585 22419 19059 22410 12562 13544 93707 215654 13543 15183 14365 22416 13542 23836 12555 12554 93876 107934 93872 270120 93884 93716 93711 116731 93710 353234 12556 56637 93709 12557 93888 14107 27373 93722 12387 192163 11994 19053 93724 18530 12936 19052 211712 93714 12939 93701 93700 12614 93723 245827 104318 93699 14314 54380 15182 54612 75560 233651 18099 59036 19058 21415 93897 12622 20379 15201 16439 140577 20437 18798 20215 18526 72293 320873 100043597 93735 103583 12234 22411 170677 21886 353235 93762 219257 12386 12565 73016 83796 54366 170735 83797 81004 77578 68058 68142 114606 14797 22422 13016 14362 13017 12941 22414 93706 18021 73181 93890 192164 93713 12937 54216 18762 20378 75599 93891 353237 93892 353236 93887 192161 93889 18750 93873 93886 12943 18751 93893 12942 53883 93874 268663 239096 13000 12558 227485 18755 245578 104010 18759 53601 13001 18752 22295 93703 18753 93708 12563 12561 279653 18754 93715 64337 14701 14700 21812 17125 17129 12166 12167 269275 11479 16438 16440 18019 328572 12914 93687 12550 DE NOVO PURINE BIOSYNTHESIS%PANTHER PATHWAY%P02738 De novo purine biosynthesis 108147 171567 56248 14923 56520 382985 20133 20135 79059 18102 433968 114873 11564 75533 54369 68870 229363 229949 231327 14450 100042069 635960 11637 11636 11565 11566 ATP SYNTHESIS%PANTHER PATHWAY%P02721 ATP synthesis 11947 11949 PNAT%PANTHER PATHWAY%P05912 PNAT 210044 66066 14704 109731 14677 13162 17161 18747 18749 14709 14678 13166 12846 19045 13823 19047 14687 13492 19087 14679 14688 19088 14693 13488 14695 14706 11513 14696 67474 22319 22317 22318 20908 19108 20619 209195 20614 214084 16527 21823 13195 269587 223604 13822 22320 13489 192176 19049 13491 PYRIMIDINE METABOLISM%PANTHER PATHWAY%P02771 Pyrimidine Metabolism 103149 104776 72269 12934 268860 23959 22240 99586 64705 65254 CADHERIN SIGNALING PATHWAY%PANTHER PATHWAY%P00012 Cadherin signaling pathway 12555 12554 93876 107934 93872 270120 93884 93716 93711 116731 93710 353234 12556 56637 93709 12557 93888 14107 12387 93722 192163 11994 93724 18530 12936 211712 93714 12939 93701 93700 12614 93723 245827 93699 14314 233651 17096 21415 93897 18526 320873 93735 22411 170677 353235 219257 12565 11461 238880 20779 22422 14362 12941 22414 93706 93890 192164 93713 12937 54216 75599 93891 353237 93892 353236 93887 192161 93889 93873 93886 12943 93893 12942 53883 93874 268663 239096 13000 12558 227485 245578 104010 53601 13001 22295 93703 93708 12563 12561 279653 93715 11465 11464 11475 11459 19246 13869 13649 14158 14302 18163 12388 13866 13867 66713 14368 14371 14369 16842 12560 14366 22412 20890 216795 14370 22612 22417 22420 22413 21416 22418 22421 22408 22409 22415 14360 22423 241201 12564 12552 73173 14367 93881 57265 93704 22419 12562 22410 93707 215654 12550 14365 22416 23836 APOPTOSIS SIGNALING PATHWAY%PANTHER PATHWAY%P00006 Apoptosis signaling pathway 26414 26397 26420 23797 22059 11651 30955 74769 18707 11652 100040260 18706 16150 18035 13163 19697 26921 18033 12915 12905 81703 225028 13804 18750 12125 14281 18751 14939 19698 18034 226641 67384 29810 26412 16992 26408 18755 26926 110213 11911 14103 18752 11798 22035 18753 11796 19766 16994 21937 18754 223922 71609 228355 12050 11797 15481 13665 11910 22030 19696 14102 21926 12369 670717 12633 26398 17210 11909 66593 19106 12049 51800 12124 15512 21933 23992 12018 14828 14082 26419 26401 15482 193740 21938 14943 12675 16004 16476 18761 12371 12367 26400 12370 11783 12028 12048 12043 26413 53859 26417 INTERFERON-GAMMA SIGNALING PATHWAY%PANTHER PATHWAY%P00035 Interferon-gamma signaling pathway 332110 26415 216233 59004 15978 12702 12700 67296 15170 16452 56468 26419 26414 15980 15979 20846 29857 26416 26420 54607 192157 16451 26413 17344 26417 229615 19094 56469 RAS PATHWAY%PANTHER PATHWAY%P04393 Ras Pathway 109880 11853 26398 11909 56637 11848 16653 18607 26414 26419 26401 26395 26397 20846 29857 11852 26416 26420 23797 26396 20111 225326 20848 16476 11651 15461 18806 30955 74769 18707 11836 17164 18176 20663 18805 19094 26400 19732 110651 20112 19353 170758 21844 26399 19354 14784 18706 26415 102626 19731 67071 66482 64143 19730 56044 18481 20807 606496 224105 23871 20662 26413 26407 26417 20416 18479 13712 110157 CHORISMATE BIOSYNTHESIS%PANTHER PATHWAY%P02734 Chorismate biosynthesis P53 PATHWAY FEEDBACK LOOPS 1%PANTHER PATHWAY%P04392 P53 pathway feedback loops 1 22061 17246 22062 22059 17248 OXYTOCIN RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04391 Oxytocin receptor mediated signaling pathway 67474 18430 22319 14710 22317 22318 14704 20908 20619 20614 14697 14709 14702 14701 22320 14700 18762 234779 74055 14672 18750 18799 114875 18751 18802 18796 18797 18795 18798 14688 18755 14675 18761 14682 18759 14693 18752 14695 18753 14706 14708 18803 14696 18754 ACETATE UTILIZATION%PANTHER PATHWAY%P02722 Acetate utilization 68738 60525 OXIDATIVE STRESS RESPONSE%PANTHER PATHWAY%P00046 Oxidative stress response 63953 105352 19252 17346 26399 13631 66959 68082 56405 13537 17347 26398 72349 17187 435391 26415 22166 18783 26419 26397 17869 20846 29857 26416 26420 12043 16476 252864 70686 75590 75219 240892 18218 80915 319520 13198 100040244 13712 240672 235584 67603 17260 19094 ALZHEIMER DISEASE-PRESENILIN PATHWAY%PANTHER PATHWAY%P00004 Alzheimer disease-presenilin pathway 11820 100042305 18549 56175 56637 18551 22068 12387 214766 18553 11787 208117 78943 94217 80890 22067 22066 12505 23821 58235 18548 22063 81601 225372 18550 19165 30800 234911 17394 14314 17393 16971 17356 17391 16480 55992 26561 217127 26946 21415 17387 93897 23948 17389 58223 17388 240047 17395 83995 93735 18554 17386 22411 228357 14725 17390 11461 238880 22422 14362 22414 11465 11464 11475 11459 13869 66713 14368 14371 14369 16842 16974 12560 16973 14366 22412 20890 216795 14370 22417 22420 22413 18129 21416 22418 22421 22408 22409 22415 22423 18131 11491 19668 14367 57265 18132 19664 22419 22410 13544 59287 13543 14365 12550 22416 13542 19164 18128 BETA3 ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04379 Beta3 adrenergic receptor signaling pathway 210044 67474 14710 22319 22317 14704 22318 20908 20619 20614 14697 14709 14702 14701 22320 14700 14680 11556 14688 14693 14695 14706 14708 11513 14696 PANTOTHENATE BIOSYNTHESIS%PANTHER PATHWAY%P02761 Pantothenate biosynthesis ALANINE BIOSYNTHESIS%PANTHER PATHWAY%P02724 Alanine biosynthesis 12036 12035 OPIOID PROOPIOMELANOCORTIN PATHWAY%PANTHER PATHWAY%P05917 Opioid proopiomelanocortin pathway 210044 67474 14710 22319 22317 14704 22318 14677 20908 20619 20614 14697 14709 14702 14678 14701 22320 14700 18386 14679 14688 18976 14681 14693 14695 14706 14708 11513 14696 TOLL RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00054 Toll receptor signaling pathway 225471 26940 266632 16179 54473 54131 66589 21353 93765 56489 18037 170744 66513 24088 21899 21929 17087 73914 620934 26409 26419 26395 16150 26397 81897 117149 18035 12675 26416 26420 170743 26396 26410 17874 22034 12475 16476 56480 21898 142980 26417 13712 VITAMIN B6 METABOLISM%PANTHER PATHWAY%P02787 Vitamin B6 metabolism 107272 216134 103711 HETEROTRIMERIC G-PROTEIN SIGNALING PATHWAY-ROD OUTER SEGMENT PHOTOTRANSDUCTION%PANTHER PATHWAY%P00028 Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction 14710 14685 14704 64337 14697 18747 18749 14709 14702 640703 19739 14701 14700 30952 18587 70405 18588 225600 12788 20028 14688 24013 14693 14699 14706 14708 19674 14696 212541 12790 UNTITLED%PANTHER PATHWAY%P06664 untitled 19697 20482 21815 HEDGEHOG SIGNALING PATHWAY%PANTHER PATHWAY%P00025 Hedgehog signaling pathway 19084 56637 12914 19087 27373 19088 319757 103583 269209 12234 14632 19085 20423 24069 93687 70790 14634 19206 PHENYLPROPIONATE DEGRADATION%PANTHER PATHWAY%P02767 Phenylpropionate degradation BETA2 ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04378 Beta2 adrenergic receptor signaling pathway 210044 14710 14704 14680 19108 14697 11555 18747 18749 14709 19087 14688 19088 14702 14693 14695 14701 14706 14708 11513 14696 14700 PURINE METABOLISM%PANTHER PATHWAY%P02769 Purine metabolism 11717 22436 14544 23959 BMP_SIGNALING_PATHWAY-DROSOPHILA%PANTHER PATHWAY%P06211 BMP_signaling_pathway-drosophila OPIOID PROENKEPHALIN PATHWAY%PANTHER PATHWAY%P05915 Opioid proenkephalin pathway 67474 210044 14710 22319 22317 14704 22318 14677 20908 20619 20614 14697 18610 14709 18619 14702 14678 14701 22320 14700 18386 14679 14688 14693 14695 14706 14708 11513 14696 SALVAGE PYRIMIDINE RIBONUCLEOTIDES%PANTHER PATHWAY%P02775 Salvage pyrimidine ribonucleotides 76654 56520 68556 331487 66757 80914 79059 433968 22271 22245 ALP23B_SIGNALING_PATHWAY%PANTHER PATHWAY%P06209 ALP23B_signaling_pathway METABOTROPIC GLUTAMATE RECEPTOR GROUP II PATHWAY%PANTHER PATHWAY%P00040 Metabotropic glutamate receptor group II pathway 108069 20907 12286 12287 67474 22319 14710 22317 66066 22318 271639 14704 14677 19108 19084 20619 20614 12295 14697 12290 18747 18749 14709 19085 14678 22320 14686 14700 19087 14679 14688 19088 56216 108068 14681 14693 14695 14706 14708 14696 LIPOATE_BIOSYNTHESIS%PANTHER PATHWAY%P02750 Lipoate_biosynthesis 79464 CELL CYCLE%PANTHER PATHWAY%P00013 Cell cycle 22123 19192 12444 67236 66997 68240 12445 69077 12447 12448 17463 19185 23997 59029 UNTITLED%PANTHER PATHWAY%P00019 untitled 210044 104110 19084 11514 11512 11515 18747 18749 432530 18783 224129 19085 18548 26395 18550 104111 14680 23797 26396 18127 18796 18797 16439 18795 11651 18798 19087 19088 18761 11836 11652 11513 230857 234889 271639 66286 56529 19091 13599 19225 13616 16438 16440 13617 19092 13614 13615 60596 107522 13618 54195 18762 14672 18750 18751 26413 14675 18755 26417 14682 18759 18752 18753 110157 18754 TYROSINE BIOSYNTHESIS%PANTHER PATHWAY%P02784 Tyrosine biosynthesis VITAMIN D METABOLISM AND PATHWAY%PANTHER PATHWAY%P04396 Vitamin D metabolism and pathway 13115 104086 19401 14473 14060 22337 20181 FGF SIGNALING PATHWAY%PANTHER PATHWAY%P00021 FGF signaling pathway 19053 19052 26414 26397 29857 26416 26420 23797 225326 18704 240752 11651 15461 30955 74769 18707 18176 11652 19094 19353 19354 18706 26415 15170 18762 234779 18750 18751 20662 26407 26408 18755 20416 18759 18752 18753 110157 18803 18754 114713 24066 20418 23980 26398 22627 22631 22628 107971 71520 26419 26395 14182 71978 14172 14171 72930 14174 14175 14179 14164 14180 26396 14165 14168 218397 14166 53608 14169 327826 14167 14184 236576 73699 80857 55948 67112 18761 24064 24063 54153 11836 100039786 51792 14178 14177 14176 20663 52432 14186 14183 269643 26400 21770 26931 26932 26399 226849 225849 26406 26405 54401 26413 26417 TOLL_PATHWAY_DROSOPHILA%PANTHER PATHWAY%P06217 Toll_pathway_drosophila HISTAMINE H1 RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04385 Histamine H1 receptor mediated signaling pathway 14710 14704 14697 14709 14702 16438 16440 14701 14700 18762 15465 234779 74055 14672 18750 18799 114875 18751 18802 18796 18797 16439 18795 18798 14688 18755 14675 18761 14682 18759 18752 14693 14695 18753 14706 14708 18803 14696 18754 METHYLMALONYL PATHWAY%PANTHER PATHWAY%P02755 Methylmalonyl pathway 110821 66904 17850 73724 5-ARACHIDONYLGLYCEROL_BIOSYNTHESIS%PANTHER PATHWAY%P05726 5-arachidonylglycerol_biosynthesis 85031 239759 269060 16956 18796 18797 18795 COENZYME A LINKED CARNITINE METABOLISM%PANTHER PATHWAY%P02732 Coenzyme A linked carnitine metabolism 192136 CHOLESTEROL BIOSYNTHESIS%PANTHER PATHWAY%P00014 Cholesterol biosynthesis 17855 110196 14137 20775 56075 15357 14593 16987 100040592 68603 192156 NICOTINIC ACETYLCHOLINE RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00044 Nicotinic acetylcholine receptor signaling pathway 17886 11465 11441 11464 17888 140781 270163 17918 11475 244281 17880 77579 17883 17885 17882 17884 246177 208943 11449 11448 217198 231252 11447 11459 226977 71602 338367 432516 17919 504186 17913 74376 17912 11461 20907 20909 102857 667663 74732 67474 68159 22319 22317 22318 228960 238880 20619 20614 11444 110834 11440 108015 11438 108043 110835 20508 12647 63993 12038 22320 11423 110902 11443 17922 17909 11435 213603 667772 54130 17910 360013 17921 17920 17916 544791 56216 71960 329421 17879 THIAMIN BIOSYNTHESIS%PANTHER PATHWAY%P02779 Thiamin biosynthesis N-ACETYLGLUCOSAMINE METABOLISM%PANTHER PATHWAY%P02756 N-acetylglucosamine metabolism 26384 74091 14583 14584 67980 245847 GAMMA-AMINOBUTYRIC ACID SYNTHESIS%PANTHER PATHWAY%P04384 Gamma-aminobutyric acid synthesis 268860 246277 214579 14417 14415 BETA1 ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04377 Beta1 adrenergic receptor signaling pathway 210044 67474 14710 22319 22317 14704 22318 20908 19108 20619 20614 14697 18747 18749 14709 14702 14701 22320 14700 14680 11554 19087 14688 19088 14693 14695 14706 14708 11513 14696 SULFATE ASSIMILATION%PANTHER PATHWAY%P02778 Sulfate assimilation ENDOGENOUS_CANNABINOID_SIGNALING%PANTHER PATHWAY%P05730 Endogenous_cannabinoid_signaling 12286 12287 14710 66066 14704 12801 14677 18796 18797 18795 14709 108071 14679 14688 12291 14816 14681 14693 14695 14706 14708 14696 ACTIVINBETASIGNALING_PATHWAY%PANTHER PATHWAY%P06210 Activinbetasignaling_pathway BIOTIN BIOSYNTHESIS%PANTHER PATHWAY%P02731 Biotin biosynthesis SERINE GLYCINE BIOSYNTHESIS%PANTHER PATHWAY%P02776 Serine glycine biosynthesis 236539 100678 107272 ALPHA ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00002 Alpha adrenergic receptor signaling pathway 58244 11549 22319 22317 22318 11551 11548 74055 14672 20619 18750 20614 18796 11553 18797 18795 18798 16438 18752 18753 11552 18754 ISOLEUCINE BIOSYNTHESIS%PANTHER PATHWAY%P02748 Isoleucine biosynthesis 12036 12035 216136 INFLAMMATION MEDIATED BY CHEMOKINE AND CYTOKINE SIGNALING PATHWAY%PANTHER PATHWAY%P00031 Inflammation mediated by chemokine and cytokine signaling pathway 12816 19229 210044 14704 14677 11512 18747 18749 14709 16653 224129 18607 20293 57260 12766 12772 14294 14293 277360 13051 23797 100038965 54446 20299 20297 20303 20304 20292 16439 11651 20296 18798 14679 20306 19224 30955 74769 14681 18707 18176 14695 11652 14706 14708 19211 11461 22371 56378 12776 667663 12775 67771 19353 68089 238880 19108 56744 12773 19354 16183 12771 12458 20302 11684 18706 12774 12765 227288 15978 11687 11690 12768 14702 67296 15975 12769 56468 54199 15945 20312 12273 22324 18021 12777 73181 16150 12145 12361 23832 80901 18762 19697 18481 214230 76709 234779 224105 14672 107589 54607 192157 18751 19698 18034 20662 16412 12818 544791 14676 71960 14675 20416 14682 18479 20130 12833 12834 16408 110157 228785 18803 12835 329421 18754 16421 17879 108058 17886 12322 11465 11867 11464 17888 140781 11475 17880 77579 11853 17883 12767 16478 213435 16477 17885 17882 71520 17884 56443 241656 11848 18783 19877 70584 11459 14678 14701 14700 12675 74055 18799 114875 18802 20848 18796 16476 18797 18795 11836 16332 18018 56212 19225 16452 16438 16440 18019 26385 74192 19736 73368 26413 26417 246709 PYRIDOXAL-5-PHOSPHATE BIOSYNTHESIS%PANTHER PATHWAY%P02759 Pyridoxal-5-phosphate biosynthesis 107272 103711 PEPTIDOGLYCAN BIOSYNTHESIS%PANTHER PATHWAY%P02763 Peptidoglycan biosynthesis INSULIN IGF PATHWAY-MITOGEN ACTIVATED PROTEIN KINASE KINASE MAP KINASE CASCADE%PANTHER PATHWAY%P00032 Insulin IGF pathway-mitogen activated protein kinase kinase MAP kinase cascade 110651 20112 73086 16367 56613 58988 67071 26395 26397 16001 16002 16000 16004 16370 23920 16337 16334 26396 20111 218397 14281 384783 20662 26413 26417 13712 110157 20663 PDGF SIGNALING PATHWAY%PANTHER PATHWAY%P00047 PDGF signaling pathway 11855 18080 11856 75415 13709 23939 68797 50772 13875 14247 260298 30051 259302 13710 332110 14390 56637 13876 94190 230233 58988 14388 14389 20847 18607 26414 17869 20111 225326 16439 232441 18708 71544 15461 320207 22282 30955 13661 74769 78177 18707 320119 76117 18176 27049 13711 11652 56501 71302 216445 19326 18710 56309 18709 69257 20112 17346 73086 56613 17347 18706 67071 22324 16150 17974 216148 234779 18750 14281 23871 20662 73167 26407 20416 18591 13712 228359 110157 18803 18590 109880 18596 114713 20418 71520 117600 18595 26419 26395 17444 20846 12675 22325 57257 26396 218397 20848 16476 20850 54153 11836 20851 17164 20852 20849 20663 16453 110651 14784 78514 16452 16438 16440 109333 20807 171207 606496 26405 16451 26413 13714 26417 TETRAHYDROFOLATE BIOSYNTHESIS%PANTHER PATHWAY%P02742 Tetrahydrofolate biosynthesis 14287 14528 13361 22171 DE NOVO PYRIMIDINE RIBONUCLEOTIDES BIOSYTHESIS%PANTHER PATHWAY%P02740 De novo pyrimidine ribonucleotides biosythesis 56520 51797 79059 55936 69719 56749 18102 227231 433968 114873 5HT3 TYPE RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04375 5HT3 type receptor mediated signaling pathway 15567 67474 22319 22317 22318 20908 20619 20614 214084 16527 110877 223604 22320 HYPOXIA RESPONSE VIA HIF ACTIVATION%PANTHER PATHWAY%P00030 Hypoxia response via HIF activation 112406 112407 56551 22346 15251 56717 19885 11863 23797 234129 11651 22166 12914 11652 19211 FLAVIN BIOSYNTHESIS%PANTHER PATHWAY%P02741 Flavin biosynthesis 319945 54391 THYROTROPIN-RELEASING HORMONE RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04394 Thyrotropin-releasing hormone receptor signaling pathway 12286 12287 14710 14704 12295 12290 14709 12296 12640 22045 14701 22044 12297 12298 22094 14700 74055 18799 114875 18802 18796 18797 18795 18798 14688 18761 14693 14695 14706 14708 14696 67474 22319 22317 22318 20908 20619 20614 14697 14702 22320 18762 234779 18750 14672 18751 18755 14675 14682 18759 18752 18753 18803 18754 UNTITLED%PANTHER PATHWAY%P05916 untitled 210044 67474 14710 22319 22317 14704 22318 14677 20908 20619 20614 14697 18429 11998 18610 14709 18387 14702 14678 14701 22320 14700 14679 14688 14681 14693 14695 14706 14708 11513 14696 THIAMINE METABOLISM%PANTHER PATHWAY%P02780 Thiamine metabolism 29807 105663 VEGF SIGNALING PATHWAY%PANTHER PATHWAY%P00056 VEGF signaling pathway 15507 109880 20698 27371 101540 18760 18783 14083 26395 16542 75292 15251 26416 26396 18127 225326 18704 107321 240752 11651 18708 15461 18761 30955 74769 21804 18707 11836 18176 17164 12955 18710 12371 18709 56632 19353 170758 19354 18706 102626 109270 12954 18762 22339 216148 234779 18750 18751 23871 73167 26413 18755 26417 18759 18752 18753 228359 110157 18803 19303 18754 TRANSCRIPTION REGULATION BY BZIP TRANSCRIPTION FACTOR%PANTHER PATHWAY%P00055 Transcription regulation by bZIP transcription factor 26427 228980 19084 208647 78284 19085 328572 69833 19183 319944 72308 22130 21374 83602 407786 63856 71828 14885 245841 100043714 14884 66420 74044 237336 68705 21341 98053 227606 68153 21343 19087 66464 12914 229906 14894 68776 19088 74197 209357 20021 66653 24074 108143 235459 208677 74238 ENKEPHALIN RELEASE%PANTHER PATHWAY%P05913 Enkephalin release 210044 14710 14704 14677 19108 14697 18747 18749 18610 14709 18619 14702 14678 14701 14700 14680 18390 18386 19087 14679 14688 19088 14681 12912 14693 14695 14706 14708 11513 14696 AXON GUIDANCE MEDIATED BY SEMAPHORINS%PANTHER PATHWAY%P00007 Axon guidance mediated by semaphorins 14302 12934 19353 14360 16801 19354 64705 12568 65254 20346 18186 20354 18844 11848 12933 235611 14159 26757 18479 PI3 KINASE PATHWAY%PANTHER PATHWAY%P00048 PI3 kinase pathway 14710 14677 16367 14697 22631 56637 18706 58988 18607 16452 56484 14678 14686 56458 16337 23797 14672 18127 19216 212111 11651 20662 54601 14679 18708 14688 320207 14675 14682 74769 18176 14693 14695 14699 11652 20663 19211 16332 18710 12371 14696 18709 DPP_SIGNALING_PATHWAY%PANTHER PATHWAY%P06213 DPP_signaling_pathway B CELL ACTIVATION%PANTHER PATHWAY%P00010 B cell activation 12478 12483 18038 12518 26419 640703 26414 26395 12675 19264 29857 22325 26416 19056 26420 19055 57257 26396 17096 16476 16439 15461 30955 74769 18707 11836 18176 20963 20663 17060 19094 12229 15985 19353 14784 19354 18706 26415 16438 26406 15170 16440 22324 16150 18035 234779 14281 18751 26405 20662 26413 26417 18753 110157 NICOTINE_DEGRADATION%PANTHER PATHWAY%P05914 Nicotine_degradation 394433 13087 22236 21743 14262 ASPARAGINE AND ASPARTATE BIOSYNTHESIS%PANTHER PATHWAY%P02730 Asparagine and aspartate biosynthesis 27053 PARKINSON DISEASE%PANTHER PATHWAY%P00049 Parkinson disease 12988 15481 23939 14191 140499 15526 13162 18000 20618 18951 19171 332110 20617 22627 14763 22631 30933 22628 54204 22195 72900 27373 50873 22223 15512 19177 26446 26965 67847 26443 14828 26444 56791 26441 26414 26419 100226 12143 19170 19166 15162 15482 26440 193740 18952 104318 53331 19167 14302 29857 26416 26420 17096 12447 55948 18806 103583 100039786 70425 103236 12448 20779 21823 22612 16818 12361 22629 171469 30931 104069 26442 14360 320129 54401 50754 26413 13000 110355 26417 13001 93687 13712 CYSTEINE BIOSYNTHESIS%PANTHER PATHWAY%P02737 Cysteine biosynthesis 12411 METABOTROPIC GLUTAMATE RECEPTOR GROUP III PATHWAY%PANTHER PATHWAY%P00039 Metabotropic glutamate receptor group III pathway 12286 12287 268934 14823 14710 14704 14677 19084 12295 12290 18747 18749 108073 14709 20510 20511 53623 14802 19085 242607 14678 14800 20512 14799 20513 14700 14810 14812 14811 14814 14813 19087 14679 14688 19088 14693 14695 14706 14708 14696 20907 67474 22319 22317 22318 271639 19108 20619 20614 14697 14805 14809 110637 22320 53611 108071 56216 14806 14816 14807 PHENYLALANINE BIOSYNTHESIS%PANTHER PATHWAY%P02765 Phenylalanine biosynthesis HISTAMINE H2 RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04386 Histamine H2 receptor mediated signaling pathway 210044 14710 14704 14680 19108 14697 18747 18749 14709 19087 15466 14688 19088 14702 14693 14695 14701 14706 14708 11513 14696 14700 AXON GUIDANCE MEDIATED BY NETRIN%PANTHER PATHWAY%P00009 Axon guidance mediated by netrin 22323 18209 19353 13176 18208 19354 69581 18706 80883 18019 18021 73181 234779 18704 22253 57764 240752 226251 107449 210801 18708 320207 30955 74769 18707 18803 18710 18709 S-ADENOSYLMETHIONINE BIOSYNTHESIS%PANTHER PATHWAY%P02773 S-adenosylmethionine biosynthesis 11720 238505 232087 FAS SIGNALING PATHWAY%PANTHER PATHWAY%P00020 FAS signaling pathway 12367 12370 11783 14102 12369 12633 26398 66445 14082 26419 26414 13163 26420 16905 227753 16476 16907 16906 12332 11546 26408 14084 13368 11545 20259 14103 12368 328417 12371 235587 TCA CYCLE%PANTHER PATHWAY%P00051 TCA cycle 14194 12974 11429 17449 18293 56451 18604 66052 18597 18598 THREONINE BIOSYNTHESIS%PANTHER PATHWAY%P02781 Threonine biosynthesis 208967 INTERLEUKIN SIGNALING PATHWAY%PANTHER PATHWAY%P00036 Interleukin signaling pathway 109880 23939 50772 332110 56637 20847 18607 17869 20846 12675 56717 23797 16156 18127 20728 20111 218397 16194 384783 16195 20848 16196 16192 12575 16193 11651 20850 74769 11836 20851 17164 18176 11652 20852 20849 20663 16453 16188 237313 16184 60505 110651 12576 20112 17346 16191 16367 13713 16183 16189 17347 16190 16169 16173 16185 18706 16171 12765 257630 16198 227288 16175 77799 20375 100042555 16162 83430 16164 67071 16155 56484 16154 16165 16150 16168 16153 16163 16161 20807 14281 20662 26413 13714 26417 20416 13712 110157 EGF RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00018 EGF receptor signaling pathway 14388 14389 20847 19053 19052 26414 26397 29857 26416 26420 23797 225326 18704 240752 11651 15461 320207 30955 74769 18707 18176 11652 19094 19353 19354 18706 26415 18762 22629 216148 234779 18750 18751 20662 26407 26408 18755 20416 18759 18752 20130 18753 110157 18803 18754 109880 114713 24066 20418 23980 26398 22627 22631 22628 71520 101540 18760 26419 13869 13649 26395 75292 83961 12402 20846 13645 17532 73523 226525 13866 12223 13867 211323 26396 218397 20848 208650 69601 236576 18015 80794 55948 18761 24064 20850 24063 54153 11836 100039786 20851 66922 210710 11839 20852 21802 20663 20849 100042150 208177 13874 18183 26400 21770 26931 26932 26399 226849 225849 26406 26405 54401 26413 26417 15200 5-HYDROXYTRYPTAMINE BIOSYNTHESIS%PANTHER PATHWAY%P04371 5-Hydroxytryptamine biosynthesis 21990 216343 13195 BLOOD COAGULATION%PANTHER PATHWAY%P00011 Blood coagulation 22371 16621 19123 14066 21788 14058 11905 14068 54368 11820 19128 58992 110135 20703 18791 14723 21824 16399 385643 18787 14069 14071 14161 99571 14724 18815 14061 14060 14729 19124 14062 18788 18816 217847 18793 14065 18792 66901 BIOGENIC AMINES ARE OXIDATIVELY DEAMINATED TO ALDEHYDES BY MAOA AND MAOB%REACTOME DATABASE ID RELEASE 57%141333 Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB 109731 17161 CHONDROITIN SULFATE BIOSYNTHESIS%REACTOME%R-HSA-2022870.1 Chondroitin sulfate biosynthesis 59031 13003 53374 78752 12032 78923 121021 74241 269941 58250 13004 12111 29873 60322 77590 13179 234356 71797 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME DATABASE ID RELEASE 57%975163 IRAK2 mediated activation of TAK1 complex upon TLR7 8 or 9 stimulation 68652 66724 22034 66513 22190 108960 26409 667035 ZINC EFFLUX AND COMPARTMENTALIZATION BY THE SLC30 FAMILY%REACTOME DATABASE ID RELEASE 57%435368 Zinc efflux and compartmentalization by the SLC30 family 239436 230810 66500 69048 22782 22784 210148 FGFR1 MUTANT RECEPTOR ACTIVATION%REACTOME%R-HSA-1839124.2 FGFR1 mutant receptor activation 64654 14173 14164 67529 20848 80857 14180 432508 20846 13047 14175 14177 21848 67384 20851 360013 20850 14389 76007 18708 18706 75296 110279 14182 244373 CITRIC ACID CYCLE (TCA CYCLE)%REACTOME DATABASE ID RELEASE 57%71403 Citric acid cycle (TCA cycle) 269951 15929 20917 66945 14194 18293 56451 66052 170718 78920 11429 18115 12974 13382 17448 20916 66925 67834 67680 REUPTAKE OF GABA%REACTOME DATABASE ID RELEASE 57%888593 Reuptake of GABA 243616 14411 14412 232333 DEFECTIVE ABCA3 CAUSES PULMONARY SURFACTANT METABOLISM DYSFUNCTION TYPE 3 (SMDP3)%REACTOME DATABASE ID RELEASE 57%5683678 Defective ABCA3 causes pulmonary surfactant metabolism dysfunction type 3 (SMDP3) 20390 20389 20388 20387 GLUCURONIDATION%REACTOME%R-HSA-156588.2 Glucuronidation 94215 94284 394436 216558 552899 100559 394433 71773 213012 231396 22236 22235 242585 100727 394434 PYRIMIDINE METABOLISM%REACTOME DATABASE ID RELEASE 57%73848 Pyrimidine metabolism 57813 23959 21877 13178 56749 50773 103850 22245 22247 22171 103149 67365 268782 76654 72269 80914 64705 22271 72962 69719 230718 99586 320685 G1 PHASE%REACTOME%R-HSA-69236.1 G1 Phase 22190 667035 19052 19053 73699 100043858 21402 12580 12567 13559 12443 104394 51792 12444 66671 54124 12445 12579 12576 12578 71978 211586 19651 19650 26965 12571 13557 12572 19645 12575 17420 13555 21781 27401 242705 TOLERANCE BY MTB TO NITRIC OXIDE PRODUCED BY MACROPHAGES%REACTOME%R-HSA-1222538.2 Tolerance by Mtb to nitric oxide produced by macrophages TELOMERE EXTENSION BY TELOMERASE%REACTOME DATABASE ID RELEASE 57%171319 Telomere Extension By Telomerase 21752 56505 52530 245474 216853 20174 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR%REACTOME DATABASE ID RELEASE 57%1234158 Regulation of gene expression by Hypoxia-inducible Factor 11863 13819 12914 230099 53417 328572 15251 22339 13856 17684 VITAMIN B2 (RIBOFLAVIN) METABOLISM%REACTOME DATABASE ID RELEASE 57%196843 Vitamin B2 (riboflavin) metabolism 11433 54391 18605 69698 319945 MISSPLICED LRP5 MUTANTS HAVE ENHANCED BETA-CATENIN-DEPENDENT SIGNALING%REACTOME DATABASE ID RELEASE 57%5339717 Misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling 234130 84035 13380 73016 16973 56811 IKBKG DEFICIENCY CAUSES ANHIDROTIC ECTODERMAL DYSPLASIA WITH IMMUNODEFICIENCY (EDA-ID) (VIA TLR)%REACTOME%R-HSA-5603027.1 IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) 18033 18036 18035 16151 18034 16150 12675 19697 PHOSPHORYLATION SITE MUTANTS OF CTNNB1 ARE NOT TARGETED TO THE PROTEASOME BY THE DESTRUCTION COMPLEX%REACTOME%R-HSA-4839743.1 phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex 11789 56637 93687 72345 21770 26932 226849 12387 12005 26931 225849 19052 19053 73699 51792 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION%REACTOME%R-HSA-2151209.1 Activation of PPARGC1A (PGC-1alpha) by phosphorylation 19017 108079 108099 241113 29857 26416 19079 108097 19094 19082 METABOLISM OF VITAMIN K%REACTOME DATABASE ID RELEASE 57%6806664 Metabolism of vitamin K 69568 27973 71707 VIRAL MESSENGER RNA SYNTHESIS%REACTOME DATABASE ID RELEASE 57%168325 Viral Messenger RNA Synthesis 218210 66679 18226 67710 69912 17749 66420 245841 227720 54563 223921 103468 70699 20021 69241 72787 269113 231042 234865 69736 19069 107939 170762 59015 227699 69833 18141 68705 20022 69920 445007 231329 98053 108989 19386 100043714 20020 69482 71805 POLB-DEPENDENT LONG PATCH BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 57%110362 POLB-Dependent Long Patch Base Excision Repair 26430 11792 18970 11545 16881 14156 11546 MITOPHAGY%REACTOME%R-HSA-5205647.1 Mitophagy 22190 66410 66119 223696 667035 66734 170731 50873 100043869 67443 67414 18412 53333 28185 22333 66169 68943 67526 11793 PEPTIDE CHAIN ELONGATION%REACTOME%R-HSA-156902.1 Peptide chain elongation 76808 68028 100043755 19899 67186 20115 57294 667739 67025 27370 65019 67248 666669 100038991 100038875 100040021 432502 66481 100040298 238217 56040 667618 19989 67891 100042986 100042740 621100 100043295 67097 13629 100043000 625646 67281 633683 666899 667035 16785 100039316 267019 100040970 19941 382492 20055 19951 100042670 68193 665189 668182 19921 20044 668144 100043423 100043893 670832 100043876 629957 225058 22121 75617 667279 76846 27050 100043184 19934 100040331 100043391 319195 68172 241053 100043209 20102 67941 27207 668668 20103 672214 622534 20085 20084 RECOGNITION OF DNA DAMAGE BY PCNA-CONTAINING REPLICATION COMPLEX%REACTOME DATABASE ID RELEASE 57%110314 Recognition of DNA damage by PCNA-containing replication complex 72584 18973 19687 69263 67967 19718 22210 99375 18972 22190 13194 18538 667035 19891 69745 68240 18971 58206 58186 59001 72151 106344 76843 230484 66979 18974 56438 68275 GLUCAGON-TYPE LIGAND RECEPTORS%REACTOME%R-HSA-420092.1 Glucagon-type ligand receptors 20287 11517 14706 14607 14696 14526 14527 11516 14602 14688 14708 14693 14709 14601 14697 14699 66066 14700 14701 14695 93896 14652 14704 14702 381853 14710 64337 MISMATCH REPAIR (MMR) DIRECTED BY MSH2:MSH6 (MUTSALPHA)%REACTOME DATABASE ID RELEASE 57%5358565 Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) 18861 67967 16881 17688 17350 17685 18972 18538 19891 69745 68240 18971 68275 26909 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC)%REACTOME DATABASE ID RELEASE 57%975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 76808 68028 100043755 19899 67186 20115 57294 667739 67025 27370 65019 67248 666669 100038991 100038875 100040021 14852 68092 225363 19704 433702 208643 14853 432502 66481 100040298 238217 56040 18458 667618 19989 67891 100042986 100042740 621100 100043295 67097 100043000 625646 67281 633683 666899 667035 16785 100039316 267019 100040970 19941 382492 20055 19951 100042670 68193 665189 668182 19921 20044 668144 100043423 100043893 670832 100043876 629957 225058 22121 75617 667279 76846 27050 100043184 19934 100040331 100043391 319195 68172 241053 100043209 20102 67941 27207 668668 20103 672214 622534 20085 20084 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE%REACTOME%R-HSA-168188.1 Toll Like Receptor TLR6:TLR2 Cascade 19094 11596 110651 12475 20210 117149 12234 17164 72349 26965 20111 12912 26400 26417 240518 26413 23939 20112 257632 266632 26420 107607 11909 16476 17260 13712 434174 22190 26414 108960 26395 26409 26401 667035 26398 26397 192656 17874 12491 67603 19052 100040260 19053 319520 73699 12229 26419 68652 11820 21402 66724 102626 22034 20203 66513 17258 24058 93765 12703 51792 26940 103583 21898 73914 26416 21770 12675 19697 21899 18033 26399 18036 231130 18035 17087 16151 18034 73086 16150 67245 93834 13211 66589 14281 24088 26410 21897 235584 16179 ATF6-ALPHA ACTIVATES CHAPERONE GENES%REACTOME%R-HSA-381183.1 ATF6-alpha activates chaperone genes 14828 18045 18046 12317 226641 22027 11911 13198 18044 UNFOLDED PROTEIN RESPONSE (UPR)%REACTOME DATABASE ID RELEASE 57%381119 Unfolded Protein Response (UPR) 14828 18045 21894 381801 28106 56495 27998 67398 140740 66362 71853 11370 13666 192193 105785 320209 16006 14583 227715 13191 13665 50911 12751 11972 57743 231997 27053 66212 69162 71765 68090 20293 72599 22642 28146 72544 66446 606496 100037258 11518 74322 16905 109075 18046 15191 12317 69276 226641 11910 22027 54616 11911 53421 100043039 13198 70640 18044 22393 56453 27362 67838 52808 78943 20818 228998 56494 50907 12282 64209 52639 66515 72662 74108 107513 69639 270669 66583 74126 20416 225849 INTERLEUKIN-2 SIGNALING%REACTOME DATABASE ID RELEASE 57%451927 Interleukin-2 signaling 56438 26395 67603 319520 235584 26403 16416 12223 54519 100042150 21894 11600 19060 19186 19188 327826 17169 194231 109905 14161 226525 57296 67151 215449 18710 19185 66998 53380 14172 17967 15461 17463 83409 69077 29875 26417 26413 12323 108058 12322 18015 59029 19197 19417 19184 19179 22190 20422 171463 14573 667035 19182 16590 240057 19181 231474 64654 80903 14173 23997 14164 66997 18039 218397 110135 14585 14178 80857 228769 14180 70247 67089 14586 14587 14175 21762 14177 23996 20416 11876 20851 14165 26554 18596 20850 109880 14389 16399 54153 18708 15200 640703 18706 18673 12325 16818 16706 69601 83379 22371 73902 233046 114716 12981 19415 63953 14174 12982 19252 16653 12984 240672 13537 12988 67836 16186 13385 14588 211323 16184 11836 20963 18188 20740 20739 13645 16185 16452 216869 109689 18176 72399 70686 114715 240168 14268 66413 211255 18183 14083 16451 19192 16453 26445 19166 16331 18218 15170 14812 76089 16332 26444 26446 14811 26443 14813 19414 80297 14814 74769 16183 20742 18707 18709 20741 21687 20743 16367 13866 14810 16192 26396 14360 16191 216148 114713 14186 19418 22123 20662 19052 14170 19053 19262 73699 640524 16913 75590 19175 19177 51792 19713 19170 22330 99571 13874 103554 16912 54401 83961 16188 19173 19172 21770 107971 26932 100986 226849 18611 23980 20418 26931 320484 225849 384783 245684 67112 110157 19167 26441 19419 11472 19171 545987 13649 70727 18595 26442 26440 19229 101809 18591 DOWNSTREAM SIGNALING OF ACTIVATED FGFR1%REACTOME DATABASE ID RELEASE 57%5654687 Downstream signaling of activated FGFR1 56438 26395 67603 319520 235584 26403 16416 12223 54519 100042150 21894 11600 19060 19186 19188 327826 17169 194231 109905 14161 226525 57296 67151 215449 18710 19185 66998 53380 14172 17967 15461 17463 83409 69077 29875 12912 26417 26413 12323 108058 12322 18015 59029 19197 19417 19184 19179 22190 20422 171463 14573 667035 19182 16590 240057 19181 231474 64654 80903 14173 23997 14164 66997 18039 218397 110135 14585 14178 80857 228769 14180 70247 67089 14586 14587 14175 21762 14177 23996 20416 11876 14165 26554 18596 109880 16399 18708 54153 15200 640703 18706 18673 12325 16818 16706 69601 83379 22371 73902 233046 114716 12981 19415 63953 14174 12982 19252 16653 12984 240672 13537 12988 67836 16186 13385 14588 211323 16184 11836 18188 20740 20739 13645 16185 16452 216869 109689 18176 72399 70686 114715 240168 14268 66413 211255 18183 14083 16451 19192 16453 26445 19166 18218 12576 14812 76089 26444 26446 14811 26443 14813 19414 80297 14814 12575 74769 16183 20742 18707 18709 20741 21687 20743 16367 13866 14810 16192 26396 14360 16191 216148 114713 14186 19418 22123 20662 19052 14170 19053 19262 73699 640524 16913 75590 19175 19177 51792 19713 19170 22330 99571 13874 103554 16912 54401 83961 56637 16188 19173 19172 21770 107971 26932 100986 226849 18611 23980 20418 26931 320484 225849 384783 12675 245684 67112 110157 19167 26441 19419 11472 19171 545987 13649 70727 18595 26442 26440 101809 18591 18750 19088 16334 76850 18753 18754 236511 19247 16337 75778 15370 18752 104110 229709 12519 12524 606496 244650 18573 12015 56717 22084 224129 77647 11513 11512 239528 11515 11514 12371 98432 117150 18803 56458 56484 213988 12326 11652 18717 12478 11651 15937 16440 78757 228775 12487 110355 18747 18574 16438 18749 217351 210044 18575 432530 233833 23797 104111 67605 18720 17246 56716 18719 214150 108083 19087 19085 18607 19084 14388 22324 396184 71436 19211 399558 227743 18718 109270 17454 16439 58988 RNA POLYMERASE III CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 57%73780 RNA Polymerase III Chain Elongation 17749 66420 245841 20016 26939 69833 70408 67486 12909 78929 20018 67065 67005 100043714 218832 69870 70428 74414 CELL CYCLE CHECKPOINTS%REACTOME DATABASE ID RELEASE 57%69620 Cell Cycle Checkpoints 69263 19718 19891 68240 66413 19192 26445 19166 12576 26444 26446 26443 12575 72151 106344 68275 22123 16913 12447 50793 93765 19175 22627 19177 19170 103554 16912 54401 19173 19172 19167 26441 19171 26909 26442 26440 70024 66156 17535 59092 12021 52206 668450 22390 319181 12237 22194 19186 100039786 19188 56150 70620 75430 216080 15204 70681 240087 57296 27214 67151 12189 17248 26374 19185 11920 66998 52717 53380 18392 26428 18393 26429 17463 231724 382522 69077 237911 70238 210766 55948 327762 27223 12448 21975 22059 19355 22631 22629 22628 52563 99152 20184 19367 12544 12545 12534 12566 269582 59004 22427 69957 12442 19356 68999 12144 68612 29813 235559 17222 59029 319183 19184 19179 12236 22190 20422 319182 319178 319186 667035 19182 319190 12427 268930 19181 107823 23997 66997 228769 70247 67089 21762 23996 17215 17219 17217 17120 29870 56452 19360 66634 235610 107976 319152 17246 68251 81601 59008 56317 225182 27354 15574 73902 50883 23834 107995 12532 12530 217232 319188 17216 15270 12649 78303 17220 12428 17218 CARNITINE SYNTHESIS%REACTOME DATABASE ID RELEASE 57%71262 Carnitine synthesis 192289 56752 20425 170442 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 57%1660499 Synthesis of PIPs at the plasma membrane 17772 104709 97287 117150 19062 30955 84095 20975 269180 18710 18705 18717 104015 18704 74302 219135 240752 67073 320207 53332 16331 234515 320634 16332 18708 18706 18720 74769 18719 18707 108083 18709 19211 18718 TNFR1-INDUCED PROAPOPTOTIC SIGNALING%REACTOME DATABASE ID RELEASE 57%5357786 TNFR1-induced proapoptotic signaling 22030 74256 53376 229603 30941 14082 21937 21926 22258 12370 71609 19766 21929 INACTIVATION OF CDC42 AND RAC%REACTOME DATABASE ID RELEASE 57%428543 Inactivation of Cdc42 and Rac 259302 19353 14270 117600 223666 20563 14733 19876 PROTEIN-PROTEIN INTERACTIONS AT SYNAPSES%REACTOME DATABASE ID RELEASE 57%6794362 Protein-protein interactions at synapses 13385 14816 13823 228836 245537 26558 108071 26557 244310 20907 226352 54525 57267 22343 380785 13169 108030 217692 12361 14812 14811 14813 14814 14810 224997 20980 171180 106025 243961 56376 26556 192167 22342 18190 53310 107065 54526 242667 20910 18189 319924 269587 74342 60510 216028 13822 216856 23859 11784 58234 20979 SIGNALING BY FGFR1%REACTOME DATABASE ID RELEASE 57%5654736 Signaling by FGFR1 17346 116701 12402 24064 56438 26395 67603 319520 235584 26403 16416 12223 54519 100042150 21894 11600 19060 19186 19188 327826 17169 194231 109905 14161 226525 57296 67151 215449 18710 19185 66998 53380 14172 17967 15461 17463 83409 69077 29875 12912 26417 26413 12323 108058 12322 18015 59029 19197 19417 19184 19179 22190 20422 171463 14573 667035 19182 16590 240057 19181 64654 231474 14173 80903 14164 23997 66997 18039 218397 110135 14585 14178 80857 228769 14180 70247 67089 14586 14587 14175 21762 14177 23996 20416 11876 14165 26554 18596 109880 16399 54153 18708 15200 640703 18706 18673 12325 16818 16706 69601 83379 22371 73902 233046 114716 12981 19415 63953 14174 12982 19252 16653 12984 240672 13537 12988 67836 16186 13385 14588 211323 16184 11836 18188 20740 20739 13645 16185 16452 216869 109689 18176 72399 70686 114715 240168 14268 66413 211255 18183 14083 16451 19192 16453 26445 19166 18218 12576 14812 76089 26444 26446 14811 26443 14813 19414 80297 14814 12575 74769 16183 20742 18707 18709 20741 21687 20743 16367 13866 14810 16192 26396 14360 16191 216148 114713 14186 19418 22123 20662 19052 14170 19053 19262 73699 640524 16913 75590 19175 19177 51792 19713 19170 22330 99571 13874 103554 16912 54401 83961 56637 16188 19173 19172 21770 107971 26932 100986 226849 18611 23980 20418 26931 320484 225849 384783 12675 245684 67112 110157 19167 26441 19419 11472 19171 545987 13649 70727 18595 26442 26440 101809 18591 18750 19088 16334 76850 18753 18754 236511 19247 16337 75778 15370 18752 104110 229709 12519 12524 606496 244650 18573 12015 56717 22084 224129 77647 11513 11512 239528 11515 11514 12371 98432 117150 18803 56458 56484 213988 12326 11652 18717 12478 11651 15937 16440 78757 228775 12487 110355 18747 18574 16438 18749 217351 210044 18575 432530 233833 23797 104111 67605 18720 17246 56716 18719 214150 108083 19087 19085 18607 19084 14388 22324 396184 71436 19211 399558 227743 18718 109270 17454 16439 58988 ABNORMAL CONVERSION OF 2-OXOGLUTARATE TO 2-HYDROXYGLUTARATE%REACTOME DATABASE ID RELEASE 57%2978092 Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate 15926 ASYMMETRIC LOCALIZATION OF PCP PROTEINS%REACTOME DATABASE ID RELEASE 57%4608870 Asymmetric localization of PCP proteins 14370 93840 66313 13543 14365 14367 75788 22418 57265 19186 19188 57296 67151 66413 19185 66998 53380 19192 26445 17463 19166 69077 26444 26446 26443 14362 56513 106042 14366 14369 22123 105782 59029 19184 22190 19179 20422 667035 19182 19181 23997 66997 16913 228769 70247 19175 67089 19177 19170 21762 23996 103554 16912 19173 19172 73902 19167 26441 19171 26442 26440 MINERALOCORTICOID BIOSYNTHESIS%REACTOME%R-HSA-193993.2 Mineralocorticoid biosynthesis 15492 15497 12640 13072 16866 13079 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS%REACTOME DATABASE ID RELEASE 57%2029480 Fcgamma receptor (FCGR) dependent phagocytosis 18753 18754 20963 229709 14083 17973 246256 17096 57257 20430 56378 330319 17913 14191 83767 242687 26417 12631 22325 74769 26413 11350 18807 15519 381925 18709 330662 66713 53357 14360 105855 14131 245880 140580 50884 19353 108100 56443 68524 11461 16885 329165 101314 140579 14129 104759 18805 18803 234779 18806 15516 12229 17886 17882 12502 76884 12928 22612 18479 16440 71910 80987 17918 76709 17925 17909 215280 16438 15162 11465 73178 22376 68089 74117 11308 18708 18706 67771 11867 22324 16439 VITAMINS B6 ACTIVATION TO PYRIDOXAL PHOSPHATE%REACTOME%R-HSA-964975.1 Vitamins B6 activation to pyridoxal phosphate 11761 216134 103711 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING%REACTOME%R-HSA-163210.1 Formation of ATP by chemiosmotic coupling 57423 11957 11946 11947 432676 228033 17705 66043 68055 11949 100039108 227112 100041835 11950 11958 CREATION OF C4 AND C2 ACTIVATORS%REACTOME DATABASE ID RELEASE 57%166786 Creation of C4 and C2 activators 12260 667277 317677 12944 12259 17195 14134 12262 TNF RECEPTOR SUPERFAMILY (TNFSF) MEMBERS MEDIATING NON-CANONICAL NF-KB PATHWAY%REACTOME DATABASE ID RELEASE 57%5676594 TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway 22030 72049 21947 53859 17000 21934 22031 24099 21943 11797 16992 27279 50930 21944 11796 16994 VEGFR2 MEDIATED CELL PROLIFERATION%REACTOME DATABASE ID RELEASE 57%5218921 VEGFR2 mediated cell proliferation 56438 26395 67603 319520 235584 26403 16416 12223 54519 100042150 21894 11600 19060 19186 19188 327826 17169 194231 109905 14161 226525 57296 67151 215449 19185 66998 53380 14172 17967 15461 17463 83409 69077 29875 26417 26413 12323 108058 12322 18015 59029 19197 19417 19184 19179 22190 20422 171463 14573 667035 19182 16590 240057 19181 231474 64654 80903 14173 23997 14164 66997 18039 218397 110135 14585 14178 80857 228769 14180 70247 67089 14586 14587 14175 21762 14177 23996 20416 11876 14165 26554 18596 109880 16399 54153 15200 640703 18673 12325 16706 69601 83379 22371 73902 233046 114716 12981 19415 63953 14174 12982 19252 16653 12984 240672 13537 12988 67836 16186 13385 14588 211323 16184 11836 18188 20740 20739 13645 16185 16452 216869 109689 18176 72399 70686 114715 240168 14268 66413 211255 18183 14083 16451 19192 16453 26445 19166 18218 14812 76089 26444 26446 14811 26443 14813 19414 80297 14814 16183 20742 20741 21687 20743 16367 13866 14810 16192 26396 14360 16191 216148 114713 14186 19418 22123 20662 19052 14170 19053 19262 73699 640524 16913 75590 19175 19177 51792 19713 19170 22330 99571 13874 103554 16912 54401 83961 16188 19173 19172 21770 26932 107971 226849 100986 18611 23980 26931 20418 225849 320484 384783 245684 67112 110157 19167 26441 19419 11472 19171 545987 13649 70727 18595 26442 26440 101809 18591 18750 18753 229709 18762 18751 20698 16542 18803 16440 16438 18607 16439 ER QUALITY CONTROL COMPARTMENT (ERQC)%REACTOME%R-HSA-901032.5 ER Quality Control Compartment (ERQC) 193670 54197 223455 116891 320011 216440 22190 667035 75841 74126 23802 66435 192193 108687 20338 22644 66597 227619 66967 COENZYME A BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 57%196783 Coenzyme A biosynthesis 269614 106564 74450 73132 71743 75735 211347 66812 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA-HYDROXYCHOLESTEROL%REACTOME%R-HSA-193368.1 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol 12012 19223 26459 13122 83702 13123 17978 17117 104086 20186 170789 77337 26458 105349 101502 208665 20181 15488 13124 27413 93732 17977 OLFACTORY SIGNALING PATHWAY%REACTOME DATABASE ID RELEASE 57%381753 Olfactory Signaling Pathway 14688 14699 258659 258640 258292 259147 258163 258443 258656 257898 258381 257917 258371 404346 258222 258296 258616 258704 258151 258405 258563 18313 258470 258672 258153 258690 18314 18312 258821 258373 257884 258358 258937 258702 258763 258179 258703 258271 259049 259066 258025 258857 258439 258836 668035 258075 259089 259012 18369 259095 258657 259092 258542 258769 258729 258347 258935 258321 259071 258487 258486 258939 258609 258268 258908 258749 259097 258318 258985 56858 258420 258776 57251 258515 259035 258531 258352 257972 258507 259063 258814 258946 258305 258759 258407 258804 258287 259074 258975 258275 404331 258506 258775 258338 258544 258387 258772 258354 259051 57271 259002 100043474 258424 259100 258147 258469 258455 258206 100038859 259058 258746 258481 259045 258355 257883 258325 258536 56015 259019 258562 258881 258713 258098 258302 258756 258478 259036 259034 258614 258319 258914 258710 258238 258694 258700 404315 259119 259075 258819 257905 258720 259047 258717 18366 404318 18367 436002 258154 258600 258160 258036 18341 258427 18330 258350 258178 404222 258322 18328 258866 258270 258990 18322 259053 258586 258869 259041 258248 258357 259110 259109 258580 258582 258587 259112 258362 258363 258575 258853 258601 258650 80706 259106 258675 259014 259054 404317 258636 259115 18365 258805 258961 258736 258882 258097 259015 258991 258944 258992 258941 258299 258618 258216 228228 244187 258572 259004 667918 257916 258697 258752 258925 258896 259122 258924 170639 668825 259113 259017 258155 258680 258303 258620 29849 258933 258606 18317 257962 258310 258395 258334 258196 18357 258715 18315 18346 258267 258922 258207 258316 546747 18343 258408 257909 258432 258832 258608 259067 18310 259040 329460 258794 258281 404329 258677 258846 117004 258016 258027 404319 545140 258930 258658 258831 218066 259013 258105 259111 258453 258706 258573 18331 257985 258340 258854 258673 258039 258980 258458 14680 18324 TRIF-MEDIATED PROGRAMMED CELL DEATH%REACTOME DATABASE ID RELEASE 57%2562578 TRIF-mediated programmed cell death 106759 12475 142980 225471 17087 56532 14082 12370 21898 19766 RIBOSOMAL SCANNING AND START CODON RECOGNITION%REACTOME DATABASE ID RELEASE 57%72702 Ribosomal scanning and start codon recognition 13665 20115 57294 667739 27370 100038875 208643 66481 100040298 67097 66235 633683 667035 16785 55944 13669 100039316 27979 267019 68135 66085 26905 22384 53356 56347 13684 67204 223691 217869 382492 13682 20055 73830 16341 100042807 13681 54709 75705 98221 20044 668144 670832 629957 225058 75617 667279 76846 27050 20102 67941 27207 668668 20103 20085 20084 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION%REACTOME DATABASE ID RELEASE 57%2565942 Regulation of PLK1 Activity at G2 M Transition 19088 76816 18817 77744 56455 76478 71909 219072 214552 237222 20873 18536 104318 22145 73738 20878 26370 74470 219103 17997 99100 74360 68121 18472 12234 27373 12009 13589 26965 54130 76707 230376 22628 66296 236266 78887 18005 15519 19046 381644 22154 225745 12534 214444 28135 231123 13427 13424 12442 83922 208518 75786 18541 103733 101565 78177 17274 69654 22153 225659 71648 16475 227613 17931 16328 22190 53598 22142 667035 68475 21402 22627 51792 103583 18747 100986 75296 NCAM SIGNALING FOR NEURITE OUT-GROWTH%REACTOME DATABASE ID RELEASE 57%375165 NCAM signaling for neurite out-growth 12827 12289 12295 12829 12297 12839 20452 12298 12830 12835 12833 11603 12828 12826 56438 26395 67603 319520 73086 235584 26403 16416 12223 54519 100042150 21894 11600 19060 19186 19188 327826 17169 194231 109905 14161 226525 57296 67151 215449 19185 66998 53380 14172 17967 15461 17463 83409 69077 29875 12912 26417 26413 13004 12323 108058 12322 18015 59029 19197 19417 19184 19179 22190 20422 171463 14573 667035 19182 16590 240057 19181 231474 64654 80903 14173 23997 14164 66997 18039 218397 110135 14585 14178 80857 228769 14180 70247 67089 14586 14587 14175 21762 14177 23996 20416 11876 14165 26554 18596 109880 16399 54153 15200 640703 18673 12325 16706 69601 83379 22371 73902 233046 114716 12981 19415 63953 14174 12982 19252 16653 12984 240672 13537 12988 67836 16186 13385 14588 211323 16184 11836 18188 20740 20739 13645 16185 16452 216869 109689 18176 72399 70686 114715 240168 14268 66413 211255 18183 14083 16451 19192 16453 26445 19166 18218 14812 76089 26444 26446 14811 26443 14813 19414 80297 14814 16183 20742 20741 21687 20743 16367 13866 14810 16192 26396 14360 16191 216148 114713 14186 19418 22123 20662 19052 14170 19053 19262 73699 640524 16913 75590 19175 19177 51792 19713 19170 22330 99571 13874 103554 16912 54401 83961 16188 19173 19172 21770 107971 26932 100986 226849 18611 23980 20418 26931 320484 225849 384783 245684 67112 110157 19167 26441 19419 11472 19171 545987 13649 70727 18595 26442 26440 101809 18591 12840 12296 58226 12291 12288 12834 20450 19122 245026 239556 21367 12841 12292 PI AND PC TRANSPORT BETWEEN ER AND GOLGI MEMBRANES%REACTOME%R-HSA-1483196.2 PI and PC transport between ER and Golgi membranes 56305 ADENOSINE P1 RECEPTORS%REACTOME DATABASE ID RELEASE 57%417973 Adenosine P1 receptors 11541 11542 11540 11539 DEFECTIVE SLCO1B1 CAUSES HYPERBILIRUBINEMIA, ROTOR TYPE (HBLRR)%REACTOME DATABASE ID RELEASE 57%5619110 Defective SLCO1B1 causes hyperbilirubinemia, Rotor type (HBLRR) 11657 SEMET INCORPORATION INTO PROTEINS%REACTOME%R-HSA-2408517.1 SeMet incorporation into proteins 104458 226414 85305 107045 66143 97541 13722 231872 107508 216443 105148 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE%REACTOME DATABASE ID RELEASE 57%174411 Polymerase switching on the C-strand of the telomere 19687 69263 67967 19718 18969 19075 18972 18538 69745 18971 72151 106344 18968 19076 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE%REACTOME%R-HSA-168138.1 Toll Like Receptor 9 (TLR9) Cascade 19094 11596 110651 20210 12234 17164 72349 26965 20111 12912 26400 26417 240518 26413 23939 20112 257632 81897 266632 216238 26420 170743 107607 78287 11909 16476 54123 17260 170744 13712 434174 22190 26414 108960 26395 26409 26401 667035 26398 72162 26397 192656 75669 17874 225326 67603 19052 100040260 19053 319520 73699 26419 68652 11820 21402 66724 102626 22034 20203 66513 17258 93765 51792 26940 103583 26416 21770 12675 19697 18033 26399 18036 231130 18035 16151 18034 73086 16150 67245 93834 13211 66589 14281 26410 235584 16179 SYNTHESIS OF DOLICHYL-PHOSPHATE-GLUCOSE%REACTOME DATABASE ID RELEASE 57%480985 Synthesis of dolichyl-phosphate-glucose 66248 66174 NOD1 2 SIGNALING PATHWAY%REACTOME%R-HSA-168638.1 NOD1 2 Signaling Pathway 74256 107607 332579 108960 26415 26409 12362 12371 11797 12370 192656 21929 29857 68652 12363 11796 66724 19094 16396 22034 12366 66513 93765 26416 12675 26399 16151 16150 257632 66589 16179 DEGRADATION OF GLI2 BY THE PROTEASOME%REACTOME DATABASE ID RELEASE 57%5610783 Degradation of GLI2 by the proteasome 19186 19188 57296 67151 66413 19185 66998 53380 19192 17463 26445 19166 69077 26444 12234 26446 26965 26443 56438 22123 59029 19184 19179 22190 20422 667035 19182 19181 23997 24069 66997 14633 21402 16913 228769 70247 19175 67089 19177 19170 18747 21762 23996 103554 18749 16912 56637 93687 19173 19172 73902 19167 26441 19171 26442 26440 CGMP EFFECTS%REACTOME DATABASE ID RELEASE 57%418457 cGMP effects 242202 16438 18573 207728 23984 17540 58802 16531 241489 19092 54611 72413 18585 18576 435726 16533 18574 INTERACTIONS OF NEUREXINS AND NEUROLIGINS AT SYNAPSES%REACTOME%R-HSA-6794361.1 Interactions of neurexins and neuroligins at synapses 13385 14816 13823 228836 245537 26558 108071 26557 244310 20907 226352 54525 57267 22343 380785 13169 108030 217692 12361 14812 14811 14813 14814 14810 224997 20980 171180 106025 243961 56376 26556 192167 22342 18190 53310 107065 54526 242667 20910 18189 319924 269587 74342 60510 216028 13822 216856 23859 11784 58234 20979 SIGNALLING TO ERK5%REACTOME%R-HSA-198765.1 Signalling to ERK5 23938 23939 SIGNALING BY FGFR IN DISEASE%REACTOME%R-HSA-1226099.3 Signaling by FGFR in disease 67710 17749 66420 245841 327826 20021 69241 18176 14172 15461 14184 14183 68092 69833 68705 433702 20022 69920 231329 98053 100043714 20020 14186 18803 64654 20662 80903 14173 14164 67529 14178 20848 80857 14180 432508 20846 13047 14175 14177 21848 67384 20851 14165 360013 20850 14389 76007 18708 18706 75296 110279 14182 244373 67112 14388 14174 16653 HSF1-DEPENDENT TRANSACTIVATION%REACTOME%R-HSA-3371571.1 HSF1-dependent transactivation 12323 108058 12322 12914 56717 328572 68196 193740 15481 81489 67605 12955 12325 15482 56716 15512 100043508 14228 74370 15519 15499 80888 15516 TRNA PROCESSING%REACTOME DATABASE ID RELEASE 57%72306 tRNA processing 218210 209584 66679 68045 18226 70047 78697 69912 102614 15108 69786 68291 227720 68626 54563 17299 223921 52575 103468 72026 70699 67106 66369 68205 72787 70359 30947 66637 229780 67724 73681 66132 68260 28088 108943 328162 66161 269113 66628 231042 104721 234865 76265 69736 94230 19069 66078 107939 170762 59015 227699 66757 18141 76357 54188 108062 28114 445007 208366 66246 13434 108989 117109 19386 68736 78890 66965 69482 106248 71805 67676 98985 67053 381802 68215 67667 227522 98404 76367 68916 319582 54364 329504 74097 60507 67674 66966 57773 233189 73192 19384 100043886 107508 212528 100929 CONJUGATION OF SALICYLATE WITH GLYCINE%REACTOME DATABASE ID RELEASE 57%177128 Conjugation of salicylate with glycine 233801 272428 107146 233799 435528 GLYCOPROTEIN HORMONES%REACTOME DATABASE ID RELEASE 57%209822 Glycoprotein hormones 14308 16324 16325 16326 12640 16866 16322 16323 22094 REGULATION BY C-FLIP%REACTOME%R-HSA-3371378.1 Regulation by c-FLIP 22030 14082 21933 14102 14103 22035 12370 71609 19766 PTK6 REGULATES RHO GTPASES, RAS GTPASE AND MAP KINASES%REACTOME%R-HSA-8849471.1 PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases 18015 140580 232906 12927 19353 20459 11848 19303 140579 240057 18176 226525 114715 218397 12928 15461 54153 19414 320484 69601 330662 114716 19415 16653 114713 101809 LIPID AND LIPOPROTEIN METABOLISM%REACTOME%R-HSA-73923.3 Lipid and lipoprotein metabolism 109791 58194 243168 68453 18550 23945 16204 103161 18453 11772 11425 14080 18553 21884 67717 19699 320024 11771 93835 71770 65969 11806 11808 70166 14311 11770 11812 240633 66113 14079 11813 11303 67469 100102 238055 11807 13131 12140 239759 18552 18946 228859 69060 19045 218203 12757 232910 16890 15450 11773 110611 19046 75497 232345 16592 208677 103968 14077 16956 11814 68680 18947 19047 14360 22359 624219 57875 30924 16835 11816 56453 171504 22259 27801 76483 22260 12389 67470 67300 17777 27409 270669 66397 100017 12613 69573 12683 11307 105847 16816 18747 56636 16891 18749 11657 ATF4 ACTIVATES GENES%REACTOME%R-HSA-380994.1 ATF4 activates genes 50911 18045 27053 64209 20293 72662 74108 72544 66446 27998 69639 66362 66583 109075 18046 11910 226641 11911 16006 13198 70640 227715 18044 POST-TRANSLATIONAL PROTEIN MODIFICATION%REACTOME%R-HSA-597592.3 Post-translational protein modification 20452 18538 56455 104318 20878 26370 13427 13424 68275 101565 69654 107607 53598 192656 231130 19186 19188 57296 67151 19185 66998 70325 53380 67241 17463 99349 20610 69077 21787 238024 53618 24070 14827 18195 19821 108154 53334 13006 78232 74493 12068 214669 30940 56389 14422 107986 15925 66111 20842 218138 545260 320713 257632 271786 22224 100683 12317 216725 84092 11504 72607 57357 207352 59029 19184 19179 20422 19182 19181 23997 66997 228769 70247 67089 21762 23996 73902 18550 20740 20739 216869 109689 66413 19192 26445 19166 26444 26446 26443 80297 20742 20741 20743 22123 228998 56494 11848 50907 640524 66397 74126 16913 19175 19177 19170 103554 16912 19173 19172 19167 26441 19171 26442 26440 16334 192193 105785 14583 13191 69162 66248 66174 20450 17246 19211 18519 27096 66313 235416 27392 171212 11842 241159 67542 11839 54644 20357 19703 235504 75540 11840 228607 17829 100689 233744 50798 102115 77371 216799 59288 170707 20448 11881 66901 74112 109785 245828 11883 11555 70527 75826 330817 380959 240119 225896 22632 78928 20687 55989 107652 21420 22658 21419 11844 234730 17156 68947 11835 70349 77125 12640 56207 12847 17063 210004 16866 18636 56174 30806 74498 20446 23794 22030 56358 74256 110616 53376 12418 229603 269328 245847 668145 30941 67902 67857 108105 232984 67228 22258 63828 213575 50935 19766 24060 21929 328370 108123 30951 108124 22217 233875 217069 217364 20451 213827 21802 19089 11843 22591 12794 436004 224836 80286 217664 17309 99011 225280 17127 105638 207958 234663 70361 20014 22428 56316 217615 14462 67511 67569 102339 71586 317717 56469 108138 66341 76630 108150 407786 83563 68137 69740 69641 230073 14376 13619 22334 78754 319651 12021 100039649 276846 56703 54383 319181 233824 54161 19025 21974 66251 67711 140474 216080 269523 15204 235323 70681 110417 240087 77038 100756 12189 19324 17248 21973 22335 21969 18701 110962 382522 97440 56447 70238 227697 210766 56737 108760 20703 27223 67292 14426 73732 22059 18700 327799 230815 19358 59040 19359 19357 20184 52036 246103 57377 107260 68837 76983 269582 56456 59004 66682 22427 16319 654821 99683 18010 360216 12144 54342 70020 170822 23956 68501 67422 224139 99412 76308 319183 89867 170711 110119 108148 22190 14425 319182 14423 319178 26409 240322 319186 667035 13032 319190 338366 12427 19128 19123 276770 230801 17158 224116 19671 353328 192156 22034 76800 66513 212996 50877 97484 319162 57295 56208 11733 229615 11735 68563 71954 329777 21951 216131 54613 19365 67909 243819 107976 269959 12836 68251 12416 54601 67872 59042 57170 18002 56324 105522 14275 107995 218214 12151 12530 68273 252870 319188 208624 20445 13426 69064 78303 208211 15387 12428 14479 67556 12764 56459 68149 66890 100042773 22225 13138 13135 116905 333883 67728 67311 193813 75302 67075 207596 108155 320438 56386 57370 56375 53418 22242 56336 331026 69080 66789 14061 226418 68142 84585 20333 11799 54128 29858 12578 271127 74008 18854 208936 17425 231050 71956 67231 22230 216185 14731 20844 210417 22223 50933 227327 107338 381903 27401 66647 67091 54198 330119 240913 50868 110350 59048 12091 15161 330267 57783 116870 433931 17131 71665 108153 13200 328572 215474 15251 77739 207839 56505 14595 107895 21826 21825 17308 241391 227195 72297 69608 208691 109359 100043429 226026 94192 21803 214895 21813 21812 17869 16494 76332 59005 58911 59007 59025 66632 11789 17125 17128 217057 17126 19763 52014 77041 243369 12005 17342 77794 16430 66124 15239 14068 14058 18035 14071 16151 14069 74996 242362 230145 338337 271970 16834 109154 319169 67727 14067 94181 218210 67819 66679 20334 18226 80294 235134 69912 241915 621893 56233 228790 227720 218811 22031 54563 76510 223921 12793 103468 216825 11797 70699 272411 56249 241062 72787 20356 72084 319189 75841 56395 235441 231727 11796 56436 14584 224697 23802 109275 66435 269181 108687 269113 68031 20338 231042 26938 22644 234865 17155 66597 69736 12638 227619 19069 15381 66967 107939 101206 319176 55981 193670 170762 14232 54197 18970 68097 223455 11545 319173 116891 52276 320011 108645 216440 54160 50797 24110 414084 239337 13481 50873 56041 100043869 74091 13480 59015 20877 227699 74270 223838 18141 71472 327942 16795 67561 445007 14799 56418 11890 108989 229595 19386 66548 20447 66226 69482 11889 71805 110379 103963 14456 68350 15267 102580 103534 13629 13478 53625 11461 223870 69714 227648 26887 98388 14537 66913 64138 20454 60409 71599 12330 28185 14534 22333 319163 320213 381694 13982 319168 72077 66889 228368 22122 319167 333424 24061 225742 22284 22196 71685 20439 235130 20843 67665 237360 12006 104416 72978 279028 228366 233733 50995 217734 18793 54399 241230 56229 100042343 20449 20442 20443 236733 226866 228812 17957 20440 20444 INNATE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 57%168249 Innate Immune System 16854 108723 239447 54483 319430 195046 16822 620235 108086 668101 16362 12628 53323 16428 16803 12772 230398 72512 20193 20201 15977 54131 66641 55991 12010 12042 12458 18521 12630 20202 216150 16904 18018 18019 268857 16643 56620 21353 22040 17444 56489 16363 329547 13038 19141 13430 18021 22072 22192 214763 103967 246082 18481 17084 13040 56743 56438 384309 16176 14375 56619 18439 53791 58203 224105 266632 26420 107607 11909 16476 17260 13712 434174 26414 26395 26401 26398 26397 192656 17874 12491 67603 100040260 319520 12229 26419 11820 102626 20203 17258 24058 93765 12703 26940 103583 21898 73914 106759 142980 225471 56532 23845 21899 11537 26399 270151 231130 12759 17087 73086 67245 93834 381809 13211 66589 14281 24088 26410 21897 235584 16179 69379 26403 71693 16416 12223 22177 110382 54519 12279 230558 12504 100042150 446099 21894 12274 11600 12273 19060 109828 19186 15139 19188 17474 327826 26888 17169 100041766 194231 27007 109905 14161 56644 226525 12266 57296 12267 67151 66105 215449 207521 18710 244332 19185 74153 66998 625018 53380 14172 19395 17967 12263 15461 629114 17463 83409 69077 29875 11596 110651 12475 20210 117149 12234 17164 72349 20111 12912 26400 26417 240518 26413 23939 20112 257632 22027 22200 12323 22166 108058 56480 12322 66824 18015 56791 59029 72029 19197 100038882 19417 383619 19184 13039 19179 20821 20422 80861 171463 19200 14573 15006 19182 17221 16590 22165 240057 12343 19181 56338 231474 217304 80903 19056 23997 19055 66997 17079 18039 13030 218397 667803 110135 13429 14585 240354 14178 14126 228769 225913 70247 52440 67089 14125 14586 12340 14587 20852 21762 268973 23996 54445 20416 11876 16409 14165 217306 26554 22370 14127 18596 77674 109880 23988 16399 16414 54153 15200 18761 640703 12043 18673 12048 12325 83433 16818 14962 16706 15896 69601 11870 83379 654464 22371 72935 73902 19058 233046 654465 114716 58217 12981 19698 19415 67955 63953 170786 14174 22596 12982 69807 19252 75400 16653 19090 12984 654460 240672 246700 13537 266620 12988 654459 67836 21682 16186 13385 14588 211323 16184 11836 20963 18188 20740 20739 13645 16185 16452 216869 109689 18176 72399 70686 114715 240168 14268 66413 211255 18183 14083 16451 19192 16453 26445 19166 238055 18218 14812 76089 26444 26446 14811 26443 14813 19414 80297 14814 74769 16183 20742 18707 18709 20741 21687 20743 16367 13866 14810 16192 26396 14360 16191 216148 114713 14186 19418 22123 20662 14170 19262 640524 16913 75590 19175 19177 19713 19170 22330 99571 13874 103554 16912 54401 83961 16188 19173 19172 107971 100986 18611 23980 20418 320484 384783 245684 67112 110157 19167 26441 19419 11472 19171 545987 13649 70727 18595 26442 26440 101809 18591 18750 19088 16334 76850 18753 18754 236511 19247 16337 75778 15370 18752 104110 229709 12519 12524 606496 81897 244650 216238 18573 170743 12015 78287 56717 54123 22084 170744 224129 77647 11513 332579 11512 26415 239528 11515 12362 11514 72162 12371 98432 75669 117150 225326 18803 56458 56484 213988 12326 11652 12363 18717 16396 12478 12366 11651 15937 16440 78757 228775 12487 110355 18747 18574 16438 18749 217351 210044 18575 432530 233833 23797 104111 67605 18720 17246 56716 18719 214150 108083 19087 19085 18607 19084 14388 22324 19211 227743 18718 109270 17454 16439 58988 54644 228607 216799 17973 246256 17096 57257 20430 56378 330319 17913 14191 83767 242687 12631 22325 11350 18807 15519 381925 330662 66713 53357 22030 74256 19353 14082 12370 19766 21929 20016 26939 70408 67486 12909 78929 217069 20018 67065 67005 19089 218832 69870 70428 74414 71586 230073 17535 216080 22190 108960 26409 667035 19128 64654 14173 14164 68652 66724 22034 66513 80857 14180 14175 14177 14389 18708 18706 333883 12576 26965 71956 12575 12914 328572 13200 19052 19053 73699 21402 51792 26416 56637 21770 26932 226849 12387 26931 225849 12675 19697 18033 18036 18035 16151 18034 16150 53859 12260 667277 17749 317677 66420 12944 245841 22031 11797 29857 11796 19094 69833 100043714 105855 14131 245880 140580 50884 108100 56443 68524 11461 16885 329165 101314 140579 14129 104759 18805 234779 18806 15516 17886 17882 12502 76884 12928 67526 22612 18479 71910 80987 17918 76709 11793 17925 17909 215280 15162 11465 73178 22376 68089 74117 11308 67771 11867 12259 17195 14134 12262 PKB-MEDIATED EVENTS%REACTOME%R-HSA-109703.2 PKB-mediated events 56717 22084 108099 19079 11652 108097 13684 19082 11651 83409 18576 75705 19042 108079 64930 241113 12283 72149 54401 13631 66096 667739 67605 56716 74370 13685 54170 208643 245670 545987 68576 20869 68441 66508 227154 52187 69008 105787 NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 57%112310 Neurotransmitter Release Cycle 20513 22348 12889 22318 268860 68507 20517 20512 14417 20511 63993 233977 242607 27204 20907 20614 214579 243616 216456 14411 20965 14412 22343 65106 232333 67111 67760 108030 14660 12647 12361 20508 327814 15481 20964 22342 19339 214084 22249 20510 14415 20518 13002 319924 17161 20979 REPRODUCTION%REACTOME%R-HSA-1474165.1 Reproduction 329954 56622 106757 22788 22787 71564 71078 12527 76856 73456 14595 75510 16532 22786 271036 320225 12659 212670 74096 11434 11495 74468 225865 EICOSANOIDS%REACTOME DATABASE ID RELEASE 57%211979 Eicosanoids 106648 100040843 72054 13120 19223 320997 631304 13124 13118 21391 64385 208285 DNA METHYLATION%REACTOME DATABASE ID RELEASE 57%5334118 DNA methylation 15267 319183 319181 319182 319178 319186 319190 232440 54427 319168 319167 382522 319176 13433 624153 13436 625328 51788 15077 13435 18140 319188 15270 319149 319169 78303 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE%REACTOME%R-HSA-168142.1 Toll Like Receptor 10 (TLR10) Cascade 19094 11596 110651 20210 12234 17164 72349 26965 20111 12912 26400 26417 240518 26413 23939 20112 257632 53791 266632 26420 107607 11909 16476 17260 13712 434174 22190 26414 108960 26395 26409 26401 667035 26398 26397 192656 17874 67603 19052 100040260 19053 319520 73699 26419 68652 11820 21402 66724 102626 22034 20203 66513 17258 93765 51792 26940 103583 26416 21770 12675 19697 18033 26399 18036 18035 231130 16151 18034 73086 16150 67245 93834 13211 66589 14281 26410 235584 16179 SIGNALING BY EGFR%REACTOME DATABASE ID RELEASE 57%177929 Signaling by EGFR 12402 24064 56438 26395 67603 319520 235584 26403 16416 12223 54519 100042150 21894 11600 19060 19186 19188 327826 17169 194231 109905 14161 226525 57296 67151 215449 18710 19185 66998 53380 14172 17967 15461 17463 83409 69077 29875 12912 26417 26413 12323 108058 12322 18015 59029 19197 19417 19184 19179 22190 20422 171463 667035 14573 19182 16590 240057 19181 64654 231474 14173 80903 14164 23997 66997 18039 218397 110135 14585 14178 80857 228769 14180 70247 67089 14586 14587 14175 21762 14177 23996 20416 11876 14165 26554 18596 109880 16399 54153 18708 15200 640703 18706 18673 12325 16818 16706 69601 83379 22371 73902 56324 233046 114716 12981 19415 63953 14174 12982 19252 16653 12984 240672 13537 12988 67836 16186 13385 58194 14588 211323 16184 11836 18188 20740 20739 13645 16185 16452 216869 109689 18176 72399 70686 114715 240168 14268 66413 211255 18183 14083 16451 19192 16453 26445 19166 18218 12576 14812 76089 26444 26446 14811 26443 14813 19414 80297 14814 12575 74769 16183 20844 20742 18707 18709 20741 21687 20743 16367 13866 14810 16192 26396 14360 16191 216148 114713 14186 19418 22123 19303 20662 19052 14170 19053 19262 73699 640524 16913 75590 19175 19177 51792 19713 19170 22330 99571 13874 103554 16912 54401 83961 56637 16188 19173 19172 21770 107971 26932 100986 226849 18611 23980 20418 26931 320484 225849 384783 12675 245684 67112 15239 110157 19167 26441 19419 11472 19171 545987 13649 70727 18595 26442 26440 101809 18591 18750 19088 16334 11487 76850 13859 18753 11489 18754 19272 236511 11491 19247 54126 16337 13858 75778 13854 15370 16206 18752 24063 104110 20404 229709 94212 12519 12524 606496 244650 18573 12015 56717 22084 224129 77647 11513 11512 239528 11515 11514 12371 98432 117150 18803 56458 56484 213988 12326 11652 18717 12478 11651 15937 16440 78757 228775 12487 110355 18747 18574 16438 18749 217351 210044 18575 432530 233833 23797 104111 67605 18720 17246 56716 18719 214150 108083 19087 19085 18607 19084 14388 22324 19211 227743 18718 109270 17454 16439 58988 VLDLR INTERNALISATION AND DEGRADATION%REACTOME%R-HSA-8866427.1 VLDLR internalisation and degradation 22260 11771 22259 67300 71770 218203 11772 12757 232910 22359 11773 100102 SYNTHESIS OF GDP-MANNOSE%REACTOME DATABASE ID RELEASE 57%446205 Synthesis of GDP-mannose 54128 29858 110119 331026 69080 TP53 REGULATES TRANSCRIPTION OF DEATH RECEPTORS AND LIGANDS%REACTOME DATABASE ID RELEASE 57%6803211 TP53 Regulates Transcription of Death Receptors and Ligands 22062 21981 22059 21933 14102 16009 209456 68742 22061 INTERLEUKIN-17 SIGNALING%REACTOME DATABASE ID RELEASE 57%448424 Interleukin-17 signaling 171095 257630 16172 234836 57890 140806 16171 50905 IRS-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME DATABASE ID RELEASE 57%2428928 IRS-related events triggered by IGF1R 667739 56438 26395 67603 319520 13684 75705 19042 64930 12283 72149 13631 66096 13685 54170 245670 68576 20869 68441 66508 227154 52187 69008 235584 105787 26403 16416 12223 54519 100042150 21894 11600 19060 19186 19188 327826 17169 194231 109905 14161 226525 57296 67151 215449 19185 66998 53380 14172 17967 15461 17463 83409 69077 29875 26417 26413 208643 12323 108058 12322 18015 59029 19197 19417 19184 19179 22190 20422 171463 14573 667035 19182 16590 240057 19181 231474 64654 80903 14173 14164 23997 66997 18039 218397 110135 14585 14178 80857 228769 14180 70247 67089 14586 14587 14175 21762 14177 23996 20416 11876 14165 26554 18596 109880 16399 18708 54153 15200 640703 18706 18673 12325 16706 69601 83379 22371 73902 233046 114716 12981 19415 63953 14174 12982 19252 16653 12984 240672 13537 12988 67836 16186 13385 14588 211323 16184 11836 18188 20740 20739 13645 16185 16452 216869 109689 18176 72399 70686 114715 240168 14268 66413 211255 18183 14083 16451 19192 16453 26445 19166 18218 14812 76089 26444 26446 14811 26443 14813 19414 80297 14814 74769 16183 20742 18709 20741 21687 20743 16367 13866 14810 16192 26396 14360 16191 216148 114713 14186 19418 22123 20662 19052 14170 19053 19262 73699 640524 16913 75590 19175 19177 51792 19713 19170 22330 99571 13874 108079 103554 241113 16912 54401 83961 16188 19173 19172 21770 107971 26932 100986 226849 18611 23980 20418 26931 320484 225849 384783 245684 67112 110157 19167 26441 19419 11472 19171 545987 13649 70727 18595 26442 26440 101809 18591 19247 75778 16000 16370 108099 16002 16001 19079 108097 19082 74370 81897 56717 22084 75669 225326 11652 11651 228775 18576 67605 56716 18607 14388 DEFECTIVE CSF2RB CAUSES PULMONARY SURFACTANT METABOLISM DYSFUNCTION 5 (SMDP5)%REACTOME DATABASE ID RELEASE 57%5688849 Defective CSF2RB causes pulmonary surfactant metabolism dysfunction 5 (SMDP5) 12982 12984 20390 20389 20388 20387 E2F MEDIATED REGULATION OF DNA REPLICATION%REACTOME%R-HSA-113510.1 E2F mediated regulation of DNA replication 57813 18969 19075 22171 18538 12427 19052 19053 73699 12447 18392 50793 26428 18393 51792 26429 56452 66634 67177 67141 20135 13361 19645 13555 21781 12544 12534 23834 12530 18968 19076 PYROPHOSPHATE HYDROLYSIS%REACTOME DATABASE ID RELEASE 57%71737 Pyrophosphate hydrolysis 67895 74776 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS%REACTOME DATABASE ID RELEASE 57%3000171 Non-integrin membrane-ECM interactions 18750 16416 13138 20971 16772 20969 16777 11603 21825 60409 14173 21803 12361 15530 16774 109711 12305 22370 22139 16403 16398 18590 16773 20970 18189 226519 16782 16780 16419 16776 15529 16775 16779 13405 18214 23928 192897 16412 57764 16410 21923 18591 REMOVAL OF AMINOTERMINAL PROPEPTIDES FROM GAMMA-CARBOXYLATED PROTEINS%REACTOME DATABASE ID RELEASE 57%159782 Removal of aminoterminal propeptides from gamma-carboxylated proteins 14456 14068 14058 14071 18550 14061 66901 19128 19123 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS%REACTOME%R-HSA-111465.1 Apoptotic cleavage of cellular proteins 12368 12369 19877 12367 227753 18753 21873 14272 13511 20740 12370 11797 27061 223255 20230 13510 12169 109620 18772 13512 14083 18810 16906 14453 21872 13169 70415 56215 22352 12550 11789 18761 269582 11518 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF)%REACTOME DATABASE ID RELEASE 57%2559584 Formation of Senescence-Associated Heterochromatin Foci (SAHF) 75560 14958 66403 15364 15361 170644 80838 22059 50708 19645 50709 14957 56702 104248 15260 16906 SNRNP ASSEMBLY%REACTOME%R-HSA-191859.2 snRNP Assembly 218210 66679 18226 69912 227720 54563 223921 103468 70699 72787 269113 231042 234865 69736 19069 107939 170762 56698 621705 67332 20638 20595 70465 66603 66069 59015 20641 227699 68092 27374 216766 18141 384091 433702 107686 53975 12729 445007 108989 19386 276919 666609 69731 69482 71805 HIGHLY SODIUM PERMEABLE ACETYLCHOLINE NICOTINIC RECEPTORS%REACTOME DATABASE ID RELEASE 57%629587 Highly sodium permeable acetylcholine nicotinic receptors 11447 11449 11438 110834 108015 11444 11448 HIV LIFE CYCLE%REACTOME DATABASE ID RELEASE 57%162587 HIV Life Cycle 194309 67897 66914 24018 18550 68776 66464 83814 235459 107305 209361 66467 18571 20833 99730 319944 18107 24074 108143 229906 100088 83602 270627 20924 20922 75608 66201 14884 76959 228980 16646 15361 12572 216185 17420 14375 268373 12767 107951 330192 20479 21374 12454 114741 24116 319583 19385 68953 66671 52348 66700 12774 18108 22088 68153 74197 23894 57314 27632 116733 226182 105513 103573 13871 13872 58202 209357 208092 14885 13716 72504 108138 67655 21343 66371 407786 67923 27224 101739 72949 19384 12455 21399 23825 218210 66679 18226 67710 69912 17749 66420 12504 245841 227720 54563 223921 103468 70699 20021 69241 72787 269113 231042 234865 69736 19069 107939 170762 16881 14156 59015 227699 68092 69833 18141 68705 433702 20022 69920 445007 231329 98053 108989 19386 100043714 20020 69482 71805 22190 667035 22596 T41 MUTANTS OF BETA-CATENIN AREN'T PHOSPHORYLATED%REACTOME DATABASE ID RELEASE 57%5358752 T41 mutants of beta-catenin aren't phosphorylated 11789 56637 93687 72345 21770 26932 226849 12387 12005 26931 225849 19052 19053 73699 51792 RESPIRATORY ELECTRON TRANSPORT%REACTOME%R-HSA-611105.2 Respiratory electron transport 66706 229211 670717 12868 68202 17992 17710 66152 17711 17709 68472 75406 70207 69702 22272 20463 231430 70316 76916 52892 17708 100040287 69487 67273 76826 66495 17991 12861 12857 22273 54405 17722 66091 100042918 104130 110323 66841 68198 110826 66694 110842 20930 73694 230075 76947 67003 100041785 67530 68493 26940 17719 66142 66379 12858 17718 72416 17717 17716 239760 66359 225887 66108 17721 66416 68375 66916 67130 78330 75597 67184 66414 623286 66218 66945 67264 68342 100042503 226646 66052 595136 72900 227197 68197 66377 66046 17995 17993 624814 66272 66925 66445 69802 67680 FOLDING OF ACTIN BY CCT TRIC%REACTOME%R-HSA-390450.1 Folding of actin by CCT TriC 12466 12467 12469 11461 12465 21454 12462 12461 12464 12468 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION%REACTOME%R-HSA-69202.1 Cyclin E associated events during G1 S transition 22390 19186 19188 57296 67151 66413 19185 66998 53380 19192 26445 17463 19166 69077 12576 17187 26444 12448 26446 26443 26965 12572 19645 12575 17420 12566 27401 22123 59029 20459 19184 19179 22190 20422 667035 19182 12427 268930 19181 23997 66997 21402 12567 16913 12447 12443 228769 70247 19175 67089 19177 17869 66671 19170 54124 21762 23996 16912 19173 19172 19167 26441 19171 12530 26442 26440 12428 POST-ELONGATION PROCESSING OF THE TRANSCRIPT%REACTOME%R-HSA-76044.1 Post-Elongation Processing of the Transcript 193116 107829 110809 225027 60365 331401 66511 68278 67337 228410 68219 19826 67996 73666 20382 53817 51786 71713 70579 116748 66231 69823 233073 73826 69207 108014 386612 72290 17149 94230 100040029 192160 625193 67332 20638 225160 20492 68092 66441 54196 54188 433702 54451 384091 108062 64340 192170 66899 622469 51796 243963 21681 18789 666609 20383 68134 269061 98985 SYNTHESIS AND PROCESSING OF GAG, GAGPOL POLYPROTEINS%REACTOME DATABASE ID RELEASE 57%174495 Synthesis And Processing Of GAG, GAGPOL Polyproteins 52348 194309 66914 18108 330192 22088 22190 107305 667035 RELEASE%REACTOME DATABASE ID RELEASE 57%168298 Release PURINE METABOLISM%REACTOME%R-HSA-73847.1 Purine metabolism 23959 13178 50773 230718 231327 11821 27369 108147 14450 14544 11717 109674 67054 23917 11564 22436 100042069 66355 237823 229665 11566 75894 11534 105446 76952 14775 76429 12359 229363 11486 15452 18950 11565 SIGNALING BY PDGF%REACTOME DATABASE ID RELEASE 57%186797 Signaling by PDGF 12827 12829 12839 12830 12835 12833 12828 12826 17973 56438 26395 67603 319520 235584 26403 16416 12223 54519 100042150 21894 11600 19060 19186 19188 327826 17169 194231 109905 14161 226525 57296 67151 215449 18710 19185 66998 53380 14172 17967 15461 17463 83409 69077 29875 12912 26417 26413 12323 108058 12322 18015 59029 19197 19417 19184 19179 22190 20422 171463 14573 667035 19182 16590 240057 19181 64654 231474 14173 80903 14164 23997 66997 18039 218397 110135 14585 20848 14178 80857 228769 14180 70247 67089 20846 14586 14587 20852 14175 21762 14177 23996 20416 11876 20851 14165 26554 18596 20850 109880 16399 54153 18708 15200 640703 18706 18673 12325 16818 16706 69601 83379 22371 73902 233046 114716 12981 19415 63953 14174 12982 19252 16653 12984 240672 13537 12988 67836 16186 13385 14588 211323 18550 16184 11836 18188 20740 20739 13645 16185 16452 216869 109689 18176 72399 70686 114715 240168 14268 66413 211255 18183 14083 16451 19192 16453 26445 19166 18218 12576 14812 76089 26444 26446 14811 26443 14813 19414 80297 14814 12575 74769 16183 20742 18707 18709 20741 21687 20743 16367 13866 14810 16192 26396 14360 16191 216148 114713 14186 19418 22123 12927 21826 21825 20662 19052 14170 19053 19262 73699 640524 16913 75590 19175 19177 51792 19713 19170 22330 99571 13874 103554 16912 54401 83961 56637 16188 19173 19172 21770 107971 26932 100986 226849 18611 23980 20418 26931 320484 225849 384783 12675 245684 67112 110157 19167 26441 19419 11472 19171 545987 13649 70727 18595 26442 26440 101809 18591 18750 19088 16334 76850 18753 18754 236511 19247 16337 75778 15370 18752 104110 229709 12519 12524 606496 244650 18573 12015 56717 22084 224129 77647 11513 11512 20750 239528 12929 11515 14786 11514 71785 12371 21827 98432 117150 18803 56458 56484 213988 12326 11652 18717 12478 11651 12928 15937 16440 78757 228775 12487 110355 18747 18574 16438 12840 18749 217351 210044 18575 432530 12834 233833 23797 104111 245026 67605 18720 17246 56716 18719 214150 12841 108083 19087 107746 19085 18607 19084 14388 18815 22324 21828 17974 18791 19211 227743 18718 109270 17454 16439 58988 RNA POLYMERASE I TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 57%73863 RNA Polymerase I Transcription Termination 66136 19285 21341 21340 20017 17749 21374 70333 66420 667501 245841 22130 66467 21429 75316 64424 20016 20018 20019 21339 14884 66671 23894 12572 17420 13871 13872 209357 69833 14885 100043714 RNA POLYMERASE II TRANSCRIPTION%REACTOME%R-HSA-73857.2 RNA Polymerase II Transcription 193116 67897 107829 110809 24018 225027 68776 60365 66464 331401 66511 68278 67337 235459 228410 68219 209361 19826 66467 67996 73666 20833 20382 99730 53817 319944 51786 71713 24074 70579 108143 116748 229906 66231 69823 83602 233073 270627 73826 20924 69207 20922 108014 14884 386612 72290 228980 17149 100040029 192160 625193 12572 67332 20638 216185 17420 225160 20492 66441 54196 54451 384091 64340 192170 66899 622469 51796 243963 21681 18789 20383 666609 68134 269061 107951 21374 12454 114741 24116 66671 98985 68153 74197 23894 57314 27632 226182 13871 13872 58202 209357 14885 13716 72504 67655 21343 67923 407786 27224 72949 12455 21399 67710 17749 66420 245841 20021 69241 94230 68092 69833 68705 433702 54188 20022 108062 69920 231329 98053 100043714 20020 214498 22083 54624 235497 76246 66317 INTERACTION BETWEEN L1 AND ANKYRINS%REACTOME DATABASE ID RELEASE 57%445095 Interaction between L1 and Ankyrins 20740 20739 20264 269116 399548 20271 640524 20272 20273 20274 110876 11733 11735 72821 16728 110862 319504 16536 80297 20266 235281 24046 20265 20742 20269 110880 20741 20743 DNA STRAND ELONGATION%REACTOME DATABASE ID RELEASE 57%69190 DNA strand elongation 19687 69263 67967 19718 18969 19075 18972 18538 19891 69745 68240 18971 17215 17219 17217 327762 16881 14156 66634 12544 72151 106344 109145 68275 272551 17216 78833 18968 69270 19076 17220 17218 REGULATION OF SIGNALING BY NODAL%REACTOME DATABASE ID RELEASE 57%1433617 Regulation of signaling by NODAL 18119 620395 269275 13590 11481 12622 320202 11479 11480 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 57%3642279 TGFBR2 MSI Frameshift Mutants in Cancer 21803 21813 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON%REACTOME DATABASE ID RELEASE 57%936964 Activation of IRF3 IRF7 mediated by TBK1 IKK epsilon 106759 56480 142980 12475 225471 54123 21353 19247 56489 22190 22031 667035 17087 54131 21898 INSULIN RECEPTOR SIGNALLING CASCADE%REACTOME DATABASE ID RELEASE 57%74751 Insulin receptor signalling cascade 667739 56438 26395 67603 319520 13684 75705 19042 64930 12283 72149 13631 66096 13685 54170 245670 68576 20869 68441 66508 227154 52187 69008 235584 105787 26403 16416 12223 54519 100042150 21894 11600 19060 19186 19188 327826 17169 194231 109905 14161 226525 57296 67151 215449 19185 66998 53380 14172 17967 15461 17463 83409 69077 29875 26417 26413 208643 12323 108058 12322 18015 59029 19197 19417 19184 19179 22190 20422 171463 14573 667035 19182 16590 240057 19181 231474 64654 80903 14173 23997 14164 66997 18039 218397 110135 14585 14178 80857 228769 14180 70247 67089 14586 14587 14175 21762 14177 23996 20416 11876 14165 26554 18596 109880 16399 18708 54153 15200 640703 18706 18673 12325 16706 69601 83379 22371 73902 233046 114716 12981 19415 63953 14174 12982 19252 16653 12984 240672 13537 12988 67836 16186 13385 14588 211323 16184 11836 18188 20740 20739 13645 16185 16452 216869 109689 18176 72399 70686 114715 240168 14268 66413 211255 18183 14083 16451 19192 16453 26445 19166 18218 14812 76089 26444 26446 14811 26443 14813 19414 80297 14814 74769 16183 20742 18709 20741 21687 20743 16367 13866 14810 16192 26396 14360 16191 216148 114713 14186 19418 22123 20662 19052 14170 19053 19262 73699 640524 16913 75590 19175 19177 51792 19713 19170 22330 99571 13874 108079 103554 241113 16912 54401 83961 16188 19173 19172 21770 107971 26932 100986 226849 18611 23980 20418 26931 320484 225849 384783 245684 67112 110157 19167 26441 19419 11472 19171 545987 13649 70727 18595 26442 26440 101809 18591 16334 19247 16337 75778 108099 19079 108097 19082 74370 14783 81897 56717 22084 75669 225326 11652 11651 228775 18576 67605 56716 18607 14388 MICRORNA (MIRNA) BIOGENESIS%REACTOME%R-HSA-203927.2 MicroRNA (miRNA) biogenesis 67710 76850 17749 66420 236511 245841 239528 20021 214150 69241 14000 72322 69833 94223 192119 20022 23992 21357 69920 231329 100043714 19384 20020 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND%REACTOME DATABASE ID RELEASE 57%174437 Removal of the Flap Intermediate from the C-strand 327762 67967 14156 18972 68275 18538 19891 69745 68240 18971 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION%REACTOME%R-HSA-69273.1 Cyclin A B1 associated events during G2 M transition 71978 22390 18817 12572 14235 12427 103573 17420 268930 12531 19052 19053 12534 73699 12566 12532 12530 12442 51792 66671 12428 AMYLOID FIBER FORMATION%REACTOME DATABASE ID RELEASE 57%977225 Amyloid fiber formation 17304 69592 16334 260302 20617 20219 18550 20437 23821 13010 19109 319181 67847 21810 68396 16432 106039 74105 14161 11806 11808 12010 230899 17002 382522 15874 319176 20210 50873 624153 625328 51788 15077 319149 15267 56791 319183 227753 22190 319182 319178 667035 319186 319190 11820 319168 319167 15530 22284 22139 20439 319188 15270 319169 78303 FGFR1B LIGAND BINDING AND ACTIVATION%REACTOME%R-HSA-190370.1 FGFR1b ligand binding and activation 67112 14173 14165 14164 14174 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R)%REACTOME DATABASE ID RELEASE 57%2404192 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 667739 56438 26395 67603 319520 13684 75705 19042 64930 12283 72149 13631 66096 13685 54170 245670 68576 20869 68441 66508 227154 52187 69008 235584 105787 26403 16416 12223 54519 100042150 21894 11600 19060 19186 19188 327826 17169 194231 109905 14161 226525 57296 67151 215449 19185 66998 53380 14172 17967 15461 17463 83409 69077 29875 26417 26413 208643 12323 108058 12322 18015 59029 19197 19417 19184 19179 22190 20422 171463 14573 667035 19182 16590 240057 19181 231474 64654 80903 14173 14164 23997 66997 18039 218397 110135 14585 14178 80857 228769 14180 70247 67089 14586 14587 14175 21762 14177 23996 20416 11876 14165 26554 18596 109880 16399 18708 54153 15200 640703 18706 18673 12325 16706 69601 83379 22371 73902 233046 114716 12981 19415 63953 14174 12982 19252 16653 12984 240672 13537 12988 67836 16186 13385 14588 211323 16184 11836 18188 20740 20739 13645 16185 16452 216869 109689 18176 72399 70686 114715 240168 14268 66413 211255 18183 14083 16451 19192 16453 26445 19166 18218 14812 76089 26444 26446 14811 26443 14813 19414 80297 14814 74769 16183 20742 18709 20741 21687 20743 16367 13866 14810 16192 26396 14360 16191 216148 114713 14186 19418 22123 20662 19052 14170 19053 19262 73699 640524 16913 75590 19175 19177 51792 19713 19170 22330 99571 13874 108079 103554 241113 16912 54401 83961 16188 19173 19172 21770 107971 26932 100986 226849 18611 23980 20418 26931 320484 225849 384783 245684 67112 110157 19167 26441 19419 11472 19171 545987 13649 70727 18595 26442 26440 101809 18591 19247 75778 16000 16370 108099 16002 16001 19079 108097 19082 74370 81897 56717 22084 75669 225326 11652 11651 228775 18576 67605 56716 18607 14388 SEROTONIN RECEPTORS%REACTOME%R-HSA-390666.1 Serotonin receptors 15563 15562 15560 15550 15566 15565 15552 15551 15559 15558 15557 IRF3-MEDIATED INDUCTION OF TYPE I IFN%REACTOME%R-HSA-3270619.1 IRF3-mediated induction of type I IFN 17535 268857 56480 22040 446099 72935 72512 207521 54131 22596 19090 14375 58203 GLUCOSE METABOLISM%REACTOME%R-HSA-70326.6 Glucose metabolism 18663 103988 216558 78830 13358 72157 230163 14447 27376 14751 14387 11674 22190 74185 13853 667035 102093 19052 50799 19053 12183 73699 26384 14719 110094 18679 74551 110078 53412 14718 17449 51792 18563 13806 18747 110095 19309 18639 18749 100043349 18640 170768 67863 13807 13808 21770 18534 77559 640703 14120 67980 18642 270198 18641 105193 56421 66681 21991 18655 72141 68961 14121 18682 27357 15275 15277 232493 17448 14936 11676 18648 56012 212032 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1)%REACTOME%R-HSA-381771.1 Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) 14695 12591 225642 64337 56529 69019 13482 66286 236781 107221 14526 18508 242851 21416 18548 16846 233081 66624 76687 TRANSLESION SYNTHESIS BY REV1%REACTOME DATABASE ID RELEASE 57%110312 Translesion synthesis by REV1 19687 69263 19718 22190 56210 18538 19891 667035 68240 71890 19714 72151 106344 68275 TOLL-LIKE RECEPTORS CASCADES%REACTOME DATABASE ID RELEASE 57%168898 Toll-Like Receptors Cascades 16803 20193 20201 54131 20202 238055 21353 26965 56489 329547 13038 19141 13430 103967 17084 13040 53791 266632 26420 107607 11909 16476 17260 13712 434174 14082 26414 26395 26401 26398 12370 26397 192656 19766 17874 12491 67603 19052 100040260 19053 319520 73699 12229 26419 11820 21402 102626 20203 17258 24058 93765 12703 51792 26940 103583 21898 73914 99571 106759 142980 26416 225471 56532 21770 12675 19697 21899 18033 26399 18036 231130 18035 17087 16151 18034 73086 16150 67245 93834 13211 66589 14281 24088 26410 21897 235584 16179 19247 22031 11797 100041766 216080 14161 66105 19094 11796 11596 110651 12475 20210 117149 12234 17164 72349 20111 12912 26400 26417 240518 26413 23939 20112 257632 22027 81897 216238 56480 170743 78287 54123 72029 170744 13039 22190 108960 26409 667035 72162 75669 225326 234779 17079 68652 13030 66724 22034 110135 13429 66513 54445 16409 16414 REGULATION OF NECROPTOTIC CELL DEATH%REACTOME DATABASE ID RELEASE 57%5675482 Regulation of necroptotic cell death 22030 11796 14082 21933 14102 14103 11798 12370 22035 11797 71609 19766 TERMINATION OF TRANSLESION DNA SYNTHESIS%REACTOME DATABASE ID RELEASE 57%5656169 Termination of translesion DNA synthesis 18973 19687 69263 56791 67967 19718 100038882 18972 22190 56210 18538 19891 667035 69745 68240 18971 217069 74153 27015 68026 80905 216835 59001 72151 106344 66979 18974 68275 22224 26447 NEGATIVE REGULATION OF THE PI3K AKT NETWORK%REACTOME%R-HSA-199418.3 Negative regulation of the PI3K AKT network 16334 12223 211323 100042150 19247 16337 75778 13645 327826 12519 12524 18710 18183 14172 26417 74769 26413 18707 18709 16367 13866 14360 14186 244650 77647 98432 16590 117150 19052 64654 19053 80903 14173 14170 14164 73699 11652 18717 12478 11651 15937 14178 80857 14180 228775 51792 12487 14175 14177 13874 14165 18596 83961 21770 23797 18708 26932 15200 226849 18706 18720 16818 26931 18719 225849 384783 108083 83379 67112 14388 22324 14174 13649 19211 18595 18718 18591 ER-PHAGOSOME PATHWAY%REACTOME DATABASE ID RELEASE 57%1236974 ER-Phagosome pathway 19186 19188 57296 67151 66413 19185 66998 12010 53380 19192 26445 17463 19166 69077 20333 21356 14991 12475 20619 14827 21355 117149 26444 26446 57743 26443 22320 66212 20909 240095 21354 15007 22319 12317 53421 100043039 22123 59029 19184 19179 22190 20422 667035 19182 15006 17874 19181 12491 23997 12229 66997 667803 16913 228769 19175 70247 19177 67089 19170 21898 21762 23996 103554 16912 19173 19172 12675 21899 73902 19167 26441 17087 16151 16150 19171 24088 26442 26440 21897 NOSIP MEDIATED ENOS TRAFFICKING%REACTOME DATABASE ID RELEASE 57%203754 NOSIP mediated eNOS trafficking 18127 66394 ACTIVATED TLR4 SIGNALLING%REACTOME DATABASE ID RELEASE 57%166054 Activated TLR4 signalling 54131 21353 26965 56489 266632 26420 107607 11909 16476 17260 13712 434174 14082 26414 26395 26401 26398 12370 26397 192656 19766 17874 12491 19052 67603 19053 100040260 73699 319520 12229 26419 21402 11820 102626 20203 17258 24058 93765 51792 12703 26940 103583 21898 73914 106759 142980 26416 225471 56532 21770 12675 19697 18033 21899 26399 18036 18035 231130 16151 17087 18034 73086 16150 67245 93834 13211 66589 14281 24088 26410 21897 235584 16179 19247 22031 11797 100041766 216080 66105 11796 19094 11596 110651 12475 20210 117149 12234 17164 72349 20111 12912 26400 26417 240518 26413 23939 20112 257632 56480 54123 22190 108960 26409 667035 68652 66724 22034 66513 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12%REACTOME DATABASE ID RELEASE 57%392170 ADP signalling through P2Y purinoceptor 12 14699 66066 14700 14701 14695 14704 14702 14710 64337 14706 14678 14696 14677 14679 242851 70839 14688 14708 14693 14709 14697 AROMATIC AMINES CAN BE N-HYDROXYLATED OR N-DEALKYLATED BY CYP1A2%REACTOME DATABASE ID RELEASE 57%211957 Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 13077 TRANSPORT OF HA TRIMER, NA TETRAMER AND M2 TETRAMER FROM THE ENDOPLASMIC RETICULUM TO THE GOLGI APPARATUS%REACTOME DATABASE ID RELEASE 57%168874 Transport of HA trimer, NA tetramer and M2 tetramer from the endoplasmic reticulum to the Golgi Apparatus NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS%REACTOME%R-HSA-418038.1 Nucleotide-like (purinergic) receptors 11540 11539 140795 67168 78826 11541 11542 70839 74191 57385 233571 235036 18441 18442 78134 574402 RNA POLYMERASE I CHAIN ELONGATION%REACTOME%R-HSA-73777.1 RNA Polymerase I Chain Elongation 17749 66420 12417 245841 319181 66467 232440 14884 382522 319176 12572 17420 624153 69833 625328 51788 15077 319149 100043714 66136 21341 21340 15267 20017 319183 70333 21374 667501 319182 319178 319186 319190 21429 75316 64424 20016 20018 20019 21339 319168 66671 319167 23894 13871 13872 209357 14885 319188 15270 78303 319169 C-TYPE LECTIN RECEPTORS (CLRS)%REACTOME DATABASE ID RELEASE 57%5621481 C-type lectin receptors (CLRs) 108723 20963 18176 66413 12042 19192 26445 19166 216150 18018 18019 17096 26444 56620 26446 26443 26965 18021 22192 18481 16176 14360 56619 224105 22123 12914 328572 12370 21402 16913 93765 19175 19177 103583 19170 103554 16912 19173 19172 12675 19697 18033 110157 19167 18035 26441 16151 18034 73086 16150 19171 381809 66589 26442 26440 53859 18753 19186 19188 17474 26888 229709 100041766 216080 56644 57296 67151 19185 66998 53380 15461 17463 69077 12234 22200 66824 59029 19184 332579 22190 19179 20422 26409 667035 19182 19181 234779 19056 23997 19055 66997 68652 66724 22034 66513 240354 18479 16440 228769 70247 67089 18747 21762 23996 16438 18749 14127 640703 15896 19058 73902 18607 19698 170786 16653 16439 BIOSYNTHESIS OF A2E, IMPLICATED IN RETINAL DEGRADATION%REACTOME%R-HSA-2466712.1 Biosynthesis of A2E, implicated in retinal degradation 242864 VESICLE-MEDIATED TRANSPORT%REACTOME DATABASE ID RELEASE 57%5653656 Vesicle-mediated transport 12827 12826 56455 104318 18472 13430 103967 13427 13424 17274 69654 22318 53598 12491 11820 20508 71693 12504 21787 20210 18195 53334 78232 12068 56389 66111 12317 22027 207352 13429 640703 17884 194309 17883 16554 66914 209737 17885 194590 17113 69834 16564 20740 215890 11772 20739 26951 107305 13645 20616 20932 17879 216869 67023 109689 66147 68938 224630 11771 54214 216705 71770 12121 19159 11806 20955 57915 225152 21987 19158 75608 19157 66201 27277 27681 76959 214459 238055 56044 210108 70218 353155 211446 20336 74741 117158 270192 53413 215114 12757 70646 232910 80297 20692 30948 67602 11773 72318 20742 218038 102058 18457 20741 12842 15505 20743 667772 12825 118454 11774 14325 15129 14623 75985 19348 16561 18476 16835 26895 11816 12000 80912 23970 330192 14620 20479 229521 14622 228998 16571 56494 30931 15463 50907 242406 12282 14616 14618 68953 14619 14613 14611 109181 27059 14725 105504 29816 67300 640524 12492 26754 70297 66397 26893 100017 71145 54609 94245 93671 11782 23969 14533 67474 16568 52348 14612 66700 16570 16572 54401 56017 22088 16971 73804 224705 74764 74438 71116 116733 14610 56085 105513 56382 16069 270160 210789 110033 286942 208092 105245 245638 231580 227746 76895 140781 66371 13649 17888 229841 16593 58244 66905 77929 16551 16334 13858 13854 20404 105785 13191 15481 69162 243764 70160 140792 107371 319642 12843 66691 232286 11652 18717 11651 21872 110355 11657 16581 14269 27096 73124 235416 69178 13543 14319 16565 11842 67542 22418 108679 11839 76688 17167 668303 252903 12402 66616 53330 11840 74947 77371 59288 245828 11555 20619 56378 17913 22320 20909 11844 15519 22319 17156 66713 53357 70349 12847 74498 14366 56358 19353 67857 213575 108123 108124 213827 21802 22627 11843 12794 20980 234663 70361 22428 217615 67511 102339 317717 60510 68137 20979 72685 20912 20661 240028 80708 16563 16573 76899 233824 15122 54161 74375 11781 100039786 78689 66251 104215 72772 108011 13423 170625 16569 77038 20615 11607 19324 12500 226089 15439 16562 71819 26891 28169 240641 68299 232943 108800 56447 117197 100043806 16552 55948 14615 20703 56367 15458 108012 18783 11768 55925 22631 230815 13132 22629 11766 22628 11998 106628 320129 52036 12848 11767 16004 26934 19325 76983 13855 76932 66682 13043 21336 544791 99683 53611 232946 20403 67489 104303 11765 11764 68505 53869 224139 233489 99412 19707 76308 228850 89867 14617 16560 218503 108148 16579 22190 20528 14423 11845 75612 13032 667035 28084 338366 73296 19330 226407 269152 19346 17158 68328 20405 20975 19345 78304 18475 104015 67804 18704 19344 22041 97484 269774 75050 20408 73470 11733 13047 22042 14621 320634 11735 16443 73094 26894 11699 30934 216131 76877 74325 380713 17920 243819 271457 19341 12836 11769 11650 192188 11777 59042 228421 12874 69940 18002 68365 56324 74015 105522 22365 14275 228960 26572 14609 66482 19338 319991 16558 13426 16594 20288 245944 98910 192187 66890 100042773 333883 193813 20333 67231 20844 107338 67091 110350 215474 69608 214895 76332 59005 108079 241113 15239 14069 338337 16834 67727 14067 20334 218811 76510 12793 108099 56395 19079 108097 19082 17155 12638 68097 54160 50797 56041 14799 56418 66226 110379 56443 227648 66913 64138 60409 17882 12502 17918 76709 73178 68089 74117 67665 67771 72978 54399 100042343 17957 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS%REACTOME DATABASE ID RELEASE 57%2173789 TGF-beta receptor signaling activates SMADs 65112 20901 66313 56424 17131 18550 170749 17872 14225 75788 68010 22190 83814 667035 12402 21803 21813 21812 17128 17127 17126 19045 103573 19046 22192 18002 56207 19047 14479 SYNTHESIS OF (16-20)-HYDROXYEICOSATETRAENOIC ACIDS (HETE)%REACTOME%R-HSA-2142816.1 Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) 13078 106648 100040843 13077 107141 13076 71519 72303 SELENOCYSTEINE SYNTHESIS%REACTOME%R-HSA-2408557.1 Selenocysteine synthesis 76808 68028 100043755 19899 67186 20115 57294 667739 67025 27370 65019 67248 666669 100038991 100038875 100040021 432502 66481 100040298 238217 56040 667618 19989 67891 100042986 100042740 621100 100043295 67097 100043000 625646 67281 633683 667035 666899 16785 100039316 267019 100040970 211006 65967 19941 214580 382492 75420 20055 20226 19951 100042670 68193 665189 668182 19921 20044 668144 100043423 100043893 670832 100043876 629957 225058 22121 75617 667279 76846 27050 100043184 19934 100040331 100043391 319195 68172 241053 100043209 20102 67941 27207 668668 20103 672214 622534 20085 20084 INFLAMMASOMES%REACTOME DATABASE ID RELEASE 57%622312 Inflammasomes 22166 54483 66824 195046 383619 12043 12048 12362 19200 19697 56338 18033 15516 18034 67955 11820 216799 55991 18439 268973 HEXOSE UPTAKE%REACTOME%R-HSA-189200.1 Hexose uptake 218210 66679 18226 69912 227720 20528 54563 223921 103468 70699 72787 20537 14385 14377 64452 103988 231103 20526 56485 269113 231042 234865 69736 56636 19069 107939 170762 20525 68401 230612 246787 14378 53881 20527 59015 227699 18141 445007 15275 15277 108989 19386 69482 71805 212032 DUAL INCISION IN GG-NER%REACTOME DATABASE ID RELEASE 57%5696400 Dual Incision in GG-NER 72584 18973 19687 69263 67967 19718 99375 18972 22190 13194 18538 667035 19891 69745 66467 68240 18971 14884 27015 22592 11545 50505 13870 23894 68058 11546 22590 13871 13872 107986 59001 209357 72151 106344 14885 66979 18974 56438 68275 PTK6 DOWN-REGULATION%REACTOME%R-HSA-8849472.1 PTK6 Down-Regulation 20459 19246 20811 CAP-DEPENDENT TRANSLATION INITIATION%REACTOME%R-HSA-72737.1 Cap-dependent Translation Initiation 76808 68028 100043755 19899 67186 20115 57294 667739 67025 27370 65019 67248 666669 100038991 100038875 100040021 432502 66481 100040298 238217 56040 667618 19989 66235 55944 13669 27979 68135 66085 26905 22384 53356 56347 13684 67204 223691 217869 13682 73830 16341 100042807 13681 54709 75705 98221 13685 13665 208643 18458 67891 100042986 100042740 621100 100043295 67097 100043000 625646 67281 633683 666899 667035 16785 100039316 267019 100040970 19941 382492 20055 19951 100042670 68193 665189 209354 668182 13667 19921 217715 20044 108067 668144 100043423 100043893 670832 100043876 629957 225058 22121 75617 667279 76846 27050 100043184 19934 100040331 100043391 319195 68172 241053 100043209 20102 67941 27207 668668 20103 672214 226982 622534 224045 20085 20084 TRANS-GOLGI NETWORK VESICLE BUDDING%REACTOME%R-HSA-199992.2 trans-Golgi Network Vesicle Budding 72685 20661 69178 14319 17113 215890 11781 252903 20404 66616 109689 108011 11840 13423 20615 216705 20955 21987 117197 20619 108012 11768 22320 15481 20909 12757 11766 67602 13430 11767 16004 18457 107338 11774 14325 232946 67489 11765 11764 80912 233489 22318 75612 68953 64138 27059 108124 67300 29816 19345 11820 67804 18704 94245 11782 22042 14533 320634 74325 74438 11769 11777 12874 15239 105245 245638 231580 77929 PLUS-STRAND DNA SYNTHESIS%REACTOME%R-HSA-164525.1 Plus-strand DNA synthesis 268373 INFECTIOUS DISEASE%REACTOME DATABASE ID RELEASE 57%5663205 Infectious disease 252903 11840 20907 12010 76808 68028 100043755 19899 67186 20115 57294 667739 67025 27370 65019 67248 666669 100038991 100038875 15007 100040021 15519 56438 432502 14375 66481 100040298 238217 56040 667618 224105 19989 22318 19353 12527 26395 26398 20614 20980 108138 407786 20979 12504 19186 19188 57296 67151 19185 66998 53380 17463 69077 12234 108012 11768 26400 11767 68092 433702 12317 11765 11764 59029 100038882 19184 19179 22190 20422 667035 19182 19181 23997 66997 228769 70247 67089 21762 23996 15200 640703 11769 16818 73902 22596 194309 67897 66914 24018 68776 18550 66464 83814 235459 11772 107305 209361 66467 18571 20833 99730 319944 18107 11771 24074 108143 71770 229906 100088 66413 83602 270627 20924 20922 75608 19192 66201 14884 26445 76959 19166 228980 16646 15361 26444 26446 26443 12757 12572 232910 216185 17420 11773 54196 26396 14360 22123 268373 12767 107951 330192 20479 21374 12454 114741 24116 319583 19385 68953 67300 21402 16913 21803 19175 19177 19170 66671 52348 66700 103554 16912 12774 18108 22088 68153 19173 74197 19172 23894 57314 27632 116733 226182 105513 103573 13871 13872 58202 209357 208092 19167 14885 26441 13716 72504 67655 19171 21343 66371 67923 27224 101739 26442 19384 72949 26440 12455 21399 23825 75717 218210 66679 100039592 18226 64176 67710 69912 17749 66420 245841 108664 227720 11740 54563 94176 223921 64051 103468 16211 70699 16648 20021 433923 69241 16649 72787 269113 231042 234865 17002 69736 19069 107939 170762 16881 14156 193740 59015 227699 69833 100037258 18141 54188 68705 20022 69920 445007 231329 98053 108989 19386 100043714 20020 69482 71805 67891 100042986 100042740 621100 140580 100043295 67097 13629 100043000 625646 67281 633683 666899 16785 100039316 267019 100040970 15516 12330 19941 382492 20055 19951 12487 100042670 68193 665189 668182 19921 15162 20044 668144 100043423 100043893 670832 100043876 629957 225058 22121 75617 667279 76846 27050 100043184 19934 18148 100040331 231413 100043391 75209 319195 50493 68172 56216 241053 11739 100043209 22317 20102 107975 67941 19106 27207 381686 668668 70572 20103 12526 672214 622534 20085 20084 BETA-OXIDATION OF PRISTANOYL-COA%REACTOME DATABASE ID RELEASE 57%389887 Beta-oxidation of pristanoyl-CoA 17117 110959 74114 170789 12908 80911 74121 15488 93732 DNA DAMAGE BYPASS%REACTOME%R-HSA-73893.1 DNA Damage Bypass 72584 18973 19687 69263 67967 56791 19718 22210 100038882 99375 22190 18972 56210 13194 18538 667035 19891 69745 68240 71890 18971 19714 269523 58206 217069 74153 68098 244666 217365 58186 27015 68026 80905 216835 22230 59001 72151 106344 76843 230484 66979 18974 56438 22224 68275 26447 NOSTRIN MEDIATED ENOS TRAFFICKING%REACTOME DATABASE ID RELEASE 57%203641 NOSTRIN mediated eNOS trafficking 12389 73178 329416 18127 13430 MRNA SPLICING%REACTOME DATABASE ID RELEASE 57%72172 mRNA Splicing 193116 110809 225027 60365 67337 228410 68219 19826 67996 20382 50996 51786 77134 71713 56194 15568 238831 67480 233073 69207 108014 18521 17149 100040029 192160 67332 20638 20641 66441 54196 54451 384091 107686 64340 192170 66899 622469 51796 21681 18789 666609 20383 68134 269061 22608 53379 13207 230596 67197 54723 56258 233908 53607 14105 66101 107701 59013 68479 70052 70767 15388 13204 68988 67797 67178 51810 60321 81898 20227 11991 330361 232989 67439 66585 98758 57905 98985 72198 319322 70233 83701 27366 76938 101943 94315 212880 15569 54633 19655 27967 76522 53317 66094 68592 66877 67678 11834 66070 192159 67958 13211 15382 50783 75062 72047 28035 78651 229279 66618 28000 67710 17749 66420 245841 20021 69241 66055 70616 20624 66373 23983 20637 20630 76167 67465 56031 94230 15381 67500 22668 68981 76936 22184 75956 71702 74351 22380 66125 15481 68816 19205 20639 20462 67959 68598 20646 80744 78372 68092 100040177 69833 67225 209416 68705 433702 54188 69192 20022 108062 74326 69920 66642 68879 231329 76479 98053 68183 66810 320632 100043714 83486 20020 27756 67285 20222 15387 STIMULATION OF THE CELL DEATH RESPONSE BY PAK-2P34%REACTOME%R-HSA-211736.1 Stimulation of the cell death response by PAK-2p34 12367 224105 HH MUTANTS ABROGATE LIGAND SECRETION%REACTOME%R-HSA-5387390.3 Hh mutants abrogate ligand secretion 13363 66753 20423 16147 19186 19188 269523 57296 67151 66413 19185 66998 53380 19192 20338 17463 26445 19166 69077 26444 116891 26446 216440 26443 22123 59029 19184 19179 22190 20422 667035 19182 19181 23997 66997 74126 16913 228769 70247 19175 67089 19177 19170 21762 23996 103554 16912 19173 19172 73902 19167 26441 19171 26442 26440 ASSEMBLY OF VIRAL COMPONENTS AT THE BUDDING SITE%REACTOME DATABASE ID RELEASE 57%168316 Assembly of Viral Components at the Budding Site 12330 12317 ACYL CHAIN REMODELLING OF PS%REACTOME%R-HSA-1482801.2 Acyl chain remodelling of PS 26971 18784 14792 78390 218121 18783 18779 225845 18782 66350 329502 18778 271844 99010 26970 26565 VRNP ASSEMBLY%REACTOME%R-HSA-192905.1 vRNP Assembly 70572 15519 M PHASE%REACTOME DATABASE ID RELEASE 57%68886 M Phase 22367 18817 67629 74549 14245 69928 105988 70099 52683 236930 68014 71175 18472 66352 208628 57294 382030 13589 68298 52696 76707 67849 67733 83815 102920 76464 218914 66570 83431 13000 67181 100039026 108911 76499 18221 12617 52432 215387 75786 70231 76044 26886 74498 66934 224640 13726 66156 16563 52206 668450 319181 12237 19186 22194 19188 56150 75430 216080 57296 67151 19324 19185 66998 53380 71819 52717 17463 69077 382522 13006 52563 26413 99152 19357 12534 20842 16319 69957 12442 68999 68612 17222 320394 226747 78658 99412 66442 76308 12615 319183 59029 72155 108000 14211 19184 13001 12236 22190 19179 60411 319182 20422 625534 319178 67956 319186 667035 232987 319190 19182 66468 56205 59021 19181 67052 52504 64898 23997 217718 66997 671392 67139 67121 59125 71782 71521 228769 70385 70247 71876 67089 73470 59126 100710 59046 21762 70454 23996 17120 319152 59008 228421 56317 73902 64899 244495 107995 381318 66336 244329 217232 67037 319188 216965 72415 15270 56430 380664 78303 30939 66977 12235 26951 66413 19192 26445 19166 11799 71978 26444 26446 26443 19645 19047 19348 22123 19052 19053 73699 16913 19175 51792 19177 19170 103554 16912 19173 73804 21770 19172 26932 226849 26931 225849 103573 19167 26441 19171 229841 26442 319169 26440 23825 18750 218210 66679 18226 69912 227720 54563 223921 103468 70699 232440 72787 18751 269113 231042 234865 69736 19069 107939 319176 170762 52276 56041 59015 20877 227699 624153 625328 18141 51788 15077 445007 108989 319149 19386 69482 71805 110379 15267 319168 16906 319167 24061 20843 67141 THE ROLE OF NEF IN HIV-1 REPLICATION AND DISEASE PATHOGENESIS%REACTOME DATABASE ID RELEASE 57%164952 The role of Nef in HIV-1 replication and disease pathogenesis 140580 19353 12504 108664 11772 94176 252903 11840 11771 71770 12010 12487 15162 108012 11768 11769 232910 16818 11773 15007 11767 107975 14360 12526 11765 11764 224105 BILE SALT AND ORGANIC ANION SLC TRANSPORTERS%REACTOME%R-HSA-425471.1 Bile salt and organic anion SLC transporters 20500 80879 67473 57274 237831 20501 114644 20503 55961 75750 12215 243755 13723 PREGNENOLONE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 57%196108 Pregnenolone biosynthesis 100042622 20845 68165 170459 11677 14148 14149 13070 170460 REGULATION OF COMMISSURAL AXON PATHFINDING BY SLIT AND ROBO%REACTOME DATABASE ID RELEASE 57%428542 Regulation of Commissural axon pathfinding by Slit and Robo 20563 268902 19876 NEGATIVE REGULATION OF TCF-DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS%REACTOME DATABASE ID RELEASE 57%3772470 Negative regulation of TCF-dependent signaling by WNT ligand antagonists 22418 24117 20319 22416 216795 234130 84035 13380 73016 16973 56811 74499 22417 20377 16974 COMPLEX I BIOGENESIS%REACTOME DATABASE ID RELEASE 57%6799198 Complex I biogenesis 66706 229211 68202 68472 75406 69702 70316 76916 67273 69487 66495 76826 17991 17722 54405 66091 104130 68198 73694 230075 76947 68493 17719 26940 17718 17717 17716 239760 225887 66108 17721 66416 68375 66916 67130 78330 75597 67184 66414 623286 66218 67264 68342 100042503 226646 595136 72900 227197 68197 66377 66046 17995 17993 624814 NEUROFASCIN INTERACTIONS%REACTOME%R-HSA-447043.1 Neurofascin interactions 269116 13193 12805 53378 53321 319504 11733 BETAKLOTHO-MEDIATED LIGAND BINDING%REACTOME%R-HSA-1307965.1 betaKlotho-mediated ligand binding 14170 14186 83379 GENE EXPRESSION%REACTOME%R-HSA-74160.4 Gene Expression 50996 77134 56194 15568 238831 67480 104318 20878 219103 27373 13000 100039026 22608 53379 13207 230596 67197 54723 56258 233908 66235 53607 14105 66101 107701 55944 59013 13669 68479 27979 70052 68135 70767 66085 15388 26905 13204 22384 68988 53356 67797 56347 67178 13684 51810 67204 60321 223691 81898 217869 20227 13682 11991 73830 330361 16341 232989 100042807 67439 13681 66585 54709 98758 75705 57905 72198 98221 319322 70233 83701 27366 76938 101943 94315 212880 15569 54633 19655 27967 76522 53317 66094 68592 66877 67678 11834 66070 192159 67958 15382 50783 75062 72047 28035 78651 229279 66618 28000 170936 68428 72611 15115 100041953 217166 244216 13197 353190 70791 50724 18227 13163 234366 72306 268936 27966 227644 22678 20182 13209 102209 433759 93681 12450 71131 237775 58184 94246 226830 80707 67207 11569 69917 22693 66653 67821 93697 233107 20183 67031 69131 27274 239546 237758 70227 17765 229542 13001 67956 671392 11816 21933 14102 22260 98985 67053 381802 68215 67667 227522 98404 76367 68916 319582 54364 329504 74097 60507 67674 66966 57773 233189 73192 19384 100043886 212528 100929 209584 68045 70047 78697 102614 15108 69786 68291 68626 17299 52575 72026 67106 66369 68205 70359 30947 66055 66637 70616 229780 20624 67724 66373 73681 23983 66132 20637 68260 20630 28088 76167 108943 328162 66161 66628 104721 67465 76265 56031 94230 67500 66078 22668 68981 76936 22184 75956 71702 74351 22380 193740 66125 15481 68816 19205 20639 20462 67959 68598 20646 74370 80744 78372 100040177 66757 67225 76357 209416 54188 69192 108062 74326 28114 66642 208366 68879 66246 76479 13434 68183 117109 66810 68736 320632 78890 83486 66965 27756 106248 67285 67676 20222 12362 12366 20226 209354 13667 217715 108067 104458 18148 226414 85305 107045 50493 66143 97541 13722 231872 226982 107508 224045 216443 105148 66313 12417 15519 56529 69019 66286 12640 66624 76687 53376 14751 20016 26939 70408 67486 12909 78929 20018 67065 67005 12447 22627 218832 69870 70428 74414 17535 59092 12021 319181 100039786 216080 240087 12189 17248 11920 231724 382522 237911 55948 327762 12448 21975 22059 19355 22631 22629 22628 19367 12534 12566 22427 19356 12144 29813 235559 319183 319182 319178 319186 319190 12427 19360 235610 81601 225182 27354 15574 50883 12532 319188 15270 12649 78303 12428 193116 107829 110809 225027 60365 331401 66511 68278 67337 228410 68219 19826 67996 73666 20382 53817 51786 71713 70579 116748 66231 69823 233073 73826 69207 108014 386612 72290 17149 100040029 670717 12868 192160 625193 225160 20492 66441 54196 54451 64340 192170 66899 622469 51796 243963 21681 18789 20383 68134 269061 17992 17710 17709 70207 20463 231430 17708 12857 100041785 66142 12858 72416 66359 66272 69802 230899 17978 14000 72322 94223 192119 23992 21357 20181 17977 66136 19285 21341 21340 20017 70333 667501 22130 11461 21429 75316 64424 20019 21339 214498 22083 54624 235497 76246 66317 69263 19718 18538 19891 68240 18521 76808 68028 100043755 19899 67186 20115 57294 667739 67025 27370 65019 67248 666669 100038991 100038875 100040021 72151 106344 68275 432502 66481 100040298 238217 56040 667618 19989 11909 16476 216456 14660 19042 64930 18861 17350 66096 17685 13685 54170 245670 13211 68576 20869 14281 68441 66508 26909 52187 105787 19186 19188 57296 66105 67151 19185 66998 53380 17463 83409 69077 17164 26417 107986 14852 68092 225363 19704 433702 208643 14853 18458 22166 59029 19184 19179 20422 19182 16590 19181 23997 66997 228769 70247 67089 21762 268973 23996 23988 73902 231464 67897 52705 64058 24018 56406 68776 56222 66464 18667 66256 269470 83814 21652 235459 67437 20832 209361 26992 66467 228839 269344 20833 244141 99730 333654 319944 24074 108143 229906 66413 83602 270627 20924 56488 20922 22704 19192 69562 14884 12393 26445 14776 19166 228980 67768 67338 26444 26446 26443 56698 621705 67332 20638 20595 70465 66603 66069 20641 27374 216766 384091 107686 13866 53975 12729 276919 666609 69731 22123 107951 21374 20818 12454 114741 24116 52892 72662 74108 107513 12861 69639 110323 66583 20930 16913 19175 19177 66379 19170 103554 16912 54401 68153 74197 19173 23894 19172 57314 27632 226182 103573 13871 13872 58202 209357 19167 14885 26441 13716 72504 67655 19171 21343 545987 67923 27224 26442 72949 26440 12455 21399 22062 18750 21981 76850 18753 236511 15370 232440 54427 27998 67398 66362 16009 209456 68742 22061 227715 13665 50911 57743 66212 13433 72544 624153 66446 13436 625328 51788 15077 13435 18140 109075 319149 53421 100043039 70640 12368 56717 22084 239528 213988 11652 11651 78757 217351 233833 23797 17246 67895 56716 74776 214150 18607 19211 227743 109270 17454 18519 330463 194388 225283 228829 101861 56707 22654 219022 107932 30944 109151 210135 74400 434377 102436 216848 77976 66249 15510 80509 230162 193452 433586 68327 106298 69228 20823 18983 15507 23942 230082 57315 225929 544971 216987 66661 78394 240064 217337 22632 75901 56314 66254 55989 22648 224823 21420 244219 27267 21419 22375 319530 210104 67134 320727 11835 233060 17165 675812 245595 18572 21771 22690 18432 74120 110052 107271 72556 74016 57746 217995 67619 71941 66214 19646 60599 22099 226539 69955 68036 75273 215193 78893 75613 103677 94112 71340 269870 18029 18032 18091 68533 21388 217038 21802 228491 21372 18027 94093 72656 103836 14219 74691 13864 21408 12122 30942 17127 67973 353187 353172 69882 15378 20014 71957 12142 59024 22385 53325 12177 544922 233893 19664 71984 327987 330890 210510 666581 212679 407786 70560 75747 449521 57745 69821 109093 74133 69020 66138 233802 12181 243906 18987 15278 619310 75137 67911 243372 13628 245368 244556 230577 216151 235682 22640 327963 110109 319801 19016 76130 12568 19013 71793 19015 19014 68915 229504 208144 13206 14463 269003 319955 14113 21849 103135 12192 235956 68975 70625 234959 20467 18997 18996 70208 264064 140486 69305 74068 230784 171285 60406 326622 381549 56771 241764 319765 140488 240068 67370 15258 59028 22321 56335 75692 234734 214133 20185 20602 330301 57230 22190 75416 233789 93836 667035 109019 78783 105372 72265 22025 73674 22026 234594 52679 238799 53319 232854 72739 12227 14791 57316 72554 69792 67235 21907 55949 71954 234374 19352 20466 71361 110960 19364 56187 56200 27993 57749 66813 17192 59035 52463 229543 382985 66656 68979 74747 110816 67160 224481 252870 67205 18477 67417 97064 381314 22775 15387 18986 18787 244713 11783 235028 101095 69181 13626 235606 209225 208836 20841 434178 332937 106931 98956 15257 69234 66262 20620 22337 110532 21677 94244 53414 102462 57432 229003 22751 66494 93762 210503 228140 23957 56417 11799 12579 23989 12576 69790 12578 75627 71978 77519 64050 211586 18854 80751 19651 19650 22709 77634 353310 15182 12572 100608 93759 216185 12575 100043168 17420 75605 13555 72181 21781 80902 24127 12905 330959 28077 12662 319618 11810 69583 66878 68147 104625 242109 245688 83456 67755 170753 12569 116870 218693 70885 17131 243834 12914 72587 218772 13200 213773 328572 19401 22339 77065 53424 19411 17684 225655 52530 70422 245474 72720 70088 224805 19052 384763 19053 69865 73699 226896 109077 619331 13496 213011 234699 20683 13559 12705 65961 104394 272347 51792 17869 63856 67390 66671 77827 22689 53621 108079 218333 241113 232791 26416 72068 66993 56637 17128 66181 71997 17126 269536 71807 68106 226517 12795 22601 26931 64934 216154 216156 116871 12053 22750 52846 233056 71063 72723 18131 101867 67371 18129 18128 319169 269704 18132 229512 72154 218210 69125 66679 14056 18226 192292 67710 26381 69912 26380 17749 238690 66420 104662 245841 17283 227720 71177 54563 21815 223921 71981 103468 333639 70699 268417 20021 234725 69241 56525 72787 12028 26379 108099 74570 57748 19079 23874 108097 22695 19094 72805 67279 19082 80886 228876 22696 269113 66590 231042 213895 234865 103806 69736 20937 15381 19069 66715 107939 666311 319176 77683 233863 170762 68017 66596 11545 19885 20482 69076 13983 225998 76390 20481 19883 52712 236193 71752 72308 20877 59015 74352 227699 231571 69833 15469 18141 70239 68705 269252 20022 68510 69920 78251 445007 18741 231329 14088 98053 211651 108989 17191 19386 432769 100043714 68744 20020 98488 69482 22757 71805 231866 103963 67891 74035 100042986 52615 100042740 11737 15267 621100 24128 100043295 110147 67097 72119 13629 98558 100043000 353258 625646 70120 67281 100041622 633683 622491 666899 50912 16785 81004 100039316 57913 267019 70470 100040970 70683 21678 21679 239652 21672 14534 223499 195522 21676 20393 13982 19941 17988 319168 382492 26896 20055 24067 19951 66384 100042670 20813 27058 319167 68193 51813 665189 72634 668182 70223 19921 21418 22284 20044 270118 22196 668144 208595 100043423 244349 100043893 72515 670832 67045 100043876 232784 629957 192657 225058 17865 22121 192651 75617 170740 667279 210529 76846 21780 27050 18130 100043184 13865 19934 16468 100040331 16477 100043391 21834 319195 21833 68172 17864 241053 210925 100043209 57750 20102 217109 67941 72180 27207 67381 668668 26423 20103 83561 672214 100041581 622534 14381 20085 72230 20084 116848 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS%REACTOME DATABASE ID RELEASE 57%1606322 ZBP1(DAI) mediated induction of type I IFNs 56480 434174 446099 17874 19766 72512 207521 54131 11820 20203 106759 11596 142980 20210 56532 12675 19697 18033 18036 18035 16151 18034 16150 13211 58203 ACTIVATION OF TRKA RECEPTORS%REACTOME DATABASE ID RELEASE 57%187015 Activation of TRKA receptors 18049 11517 18211 18212 11516 11540 RECYCLING OF BILE ACIDS AND SALTS%REACTOME DATABASE ID RELEASE 57%159418 Recycling of bile acids and salts 16204 12012 26459 17978 20186 20493 28250 28253 20494 11657 76408 20181 27413 17977 TRANSCRIPTIONAL REGULATION BY THE AP-2 (TFAP2) FAMILY OF TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 57%8864260 Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 12914 56222 328572 22339 332937 106931 17684 16590 15510 226896 110109 13982 12705 21802 17869 21418 22196 64050 22632 17865 21420 12575 75605 21419 80707 18148 13866 233107 12640 18741 110052 11816 MAPK FAMILY SIGNALING CASCADES%REACTOME DATABASE ID RELEASE 57%5683057 MAPK family signaling cascades 15507 18481 17165 56438 224105 16476 19353 26395 67603 319520 235584 26403 16416 12223 54519 100042150 21894 11600 19060 19186 19188 327826 17169 194231 109905 14161 226525 57296 67151 215449 19185 66998 53380 14172 17967 15461 17463 83409 69077 29875 26417 26413 140486 12534 12323 108058 12322 18015 59029 19197 19417 19184 19179 22190 20422 171463 14573 667035 19182 16590 240057 19181 231474 64654 80903 14173 23997 14164 66997 18039 218397 110135 14585 14178 80857 228769 14180 70247 67089 14586 14587 14175 21762 14177 23996 20416 11876 14165 26554 18596 109880 16399 54153 15200 640703 18673 12325 16706 69601 83379 22371 73902 233046 114716 12981 19415 63953 14174 12982 19252 16653 12984 240672 13537 12988 67836 16186 13385 14588 211323 16184 11836 18188 20740 20739 13645 16185 16452 216869 109689 18176 72399 70686 545156 114715 240168 14268 66413 211255 18183 14083 16451 19192 16453 26445 19166 18218 16194 14812 16193 76089 58804 26444 260409 26446 235072 14811 19374 26443 19373 14813 17979 19414 54721 80297 18612 14814 104252 225724 16183 50772 20742 218294 229776 20741 21687 20743 16367 13866 14810 16192 26396 14360 16191 216148 114713 14186 19418 22123 20662 19052 14170 19053 19262 73699 640524 16913 75590 19175 19177 51792 19713 17869 19170 22330 99571 12445 13874 103554 16912 54401 83961 16188 19173 19172 21770 107971 26932 100986 226849 18611 23980 20418 26931 320484 103573 225849 384783 245684 67112 110157 19167 26441 19419 11472 19171 545987 13649 70727 18595 26442 26440 101809 18591 76850 236511 19247 81489 239528 56458 56484 213988 18479 18747 18749 217351 233833 214150 17454 SUMO E3 LIGASES SUMOYLATE TARGET PROTEINS%REACTOME DATABASE ID RELEASE 57%3108232 SUMO E3 ligases SUMOylate target proteins 13619 218210 66679 18226 241915 69912 56233 54383 227720 54563 223921 18538 103468 21974 70699 67711 72787 15204 240087 12189 21973 21969 269113 231042 67241 20878 234865 26370 69736 20610 19069 15381 107939 70238 11799 170762 12578 27223 11545 19821 18854 52276 22059 13006 20687 55989 214669 21420 19357 22658 21419 59015 20877 227699 18141 20842 59004 66647 22427 16319 445007 68275 108989 19386 12144 69482 71805 68501 116870 12418 30951 100043429 226026 22591 229615 24061 22196 19365 20843 19763 12416 17246 17342 67872 56469 12151 108138 66341 15387 SIGNALING BY OVEREXPRESSED WILD-TYPE EGFR IN CANCER%REACTOME DATABASE ID RELEASE 57%5638302 Signaling by Overexpressed Wild-Type EGFR in Cancer 13649 13645 AMER1 MUTANTS DESTABILIZE THE DESTRUCTION COMPLEX%REACTOME DATABASE ID RELEASE 57%4839748 AMER1 mutants destabilize the destruction complex 11789 56637 93687 72345 21770 26932 226849 12005 26931 225849 19052 19053 73699 51792 ION CHANNEL TRANSPORT%REACTOME%R-HSA-983712.1 Ion channel transport 83814 15561 14628 14395 94178 235574 338370 14394 404545 50770 14397 54667 14399 11982 110886 74915 54670 14396 14401 14402 14408 14407 11931 140475 170755 14400 21871 236915 102566 193034 14406 241118 24115 65973 226025 22063 58800 328699 100039636 14409 22065 194352 11928 208169 56843 69047 117160 232975 98660 192113 11966 22066 229277 76295 170759 20191 171166 20192 22068 67331 11973 64177 22067 11964 110935 28240 11932 110157 11938 14658 53313 14654 11937 237213 252972 11980 381290 320707 67972 14226 57014 20190 11933 243634 110304 72621 105355 217843 97086 17364 66290 212989 108664 26946 320940 68279 74772 74446 57780 59095 56407 58170 66388 382014 109552 268878 11974 13830 105722 242341 27219 11945 11944 225997 11941 233979 114143 11975 11419 246788 68775 11972 229933 66237 23844 63873 54411 26373 99663 12733 26372 231287 56365 20276 233246 66144 20277 76757 20278 277328 11977 224079 338375 279561 66335 76252 171382 107568 108017 320091 12323 382427 108058 101772 12322 56188 232341 11981 22368 14605 69847 22190 27060 57249 73834 667035 140494 12723 319767 75607 12727 12725 11979 12728 14657 68667 12724 78339 20393 50769 50771 640703 12325 SCAVENGING BY CLASS B RECEPTORS%REACTOME DATABASE ID RELEASE 57%3000471 Scavenging by Class B Receptors 20210 11806 238055 12491 HYDROXYCARBOXYLIC ACID-BINDING RECEPTORS%REACTOME%R-HSA-3296197.1 Hydroxycarboxylic acid-binding receptors 243270 80885 INFLUENZA VIRUS INDUCED APOPTOSIS%REACTOME%R-HSA-168277.2 Influenza Virus Induced Apoptosis 21803 11740 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION%REACTOME DATABASE ID RELEASE 57%3134963 DEx H-box helicases activate type I IFN and inflammatory cytokines production 11596 18033 20210 54123 18034 11820 434174 20203 13211 72162 17874 19697 P75 NTR RECEPTOR-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 57%193704 p75 NTR receptor-mediated signalling 11491 54126 18049 59287 545156 192662 18759 224014 269608 20598 101497 13605 94275 75547 26382 16800 16801 57257 433759 15182 67733 22325 19418 12015 12367 19353 11848 22190 236915 667035 192656 17874 20662 18412 26419 22034 12366 22627 71704 15183 213498 102098 16443 277360 226970 207212 20663 73341 208117 56349 17136 18053 12125 68585 171207 24001 235402 223435 19697 109904 18033 19165 12070 18035 100039623 72843 100042305 16150 22324 56321 109934 69632 18377 30938 21844 17207 230972 213649 53972 16179 14163 ZINC TRANSPORTERS%REACTOME DATABASE ID RELEASE 57%435354 Zinc transporters 239436 230810 66500 214922 30791 67547 69048 106947 22782 72002 22784 213053 106957 210148 14977 227059 72027 INTEGRATION OF VIRAL DNA INTO HOST GENOMIC DNA%REACTOME%R-HSA-175567.1 Integration of viral DNA into host genomic DNA 15361 101739 23825 CYP2E1 REACTIONS%REACTOME DATABASE ID RELEASE 57%211999 CYP2E1 reactions 56448 13107 13087 13088 74134 13106 107141 72303 INHIBITION OF HOST MRNA PROCESSING AND RNA SILENCING%REACTOME DATABASE ID RELEASE 57%168315 Inhibition of Host mRNA Processing and RNA Silencing 54196 54188 HEDGEHOG 'ON' STATE%REACTOME DATABASE ID RELEASE 57%5632684 Hedgehog 'on' state 15245 66573 66313 57810 13363 75788 20423 16147 19186 19188 216869 109689 57296 67151 66413 19185 66998 53380 19192 26445 17463 19166 69077 26444 26446 26443 14632 74239 240888 117606 19206 104346 14634 319757 56438 18222 230500 68525 71742 76857 14451 20747 59056 22123 59029 19184 19179 22190 20422 667035 19182 19181 23997 24069 66997 14633 16396 16913 228769 214498 19175 70247 19177 67089 110355 19170 21762 23996 16568 103554 16912 26554 93687 19173 19172 73902 19167 26441 19171 26442 26440 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY%REACTOME%R-HSA-442380.1 Zinc influx into cells by the SLC39 gene family 14977 227059 72027 214922 30791 67547 106947 72002 213053 106957 ACTIVATED PKN1 STIMULATES TRANSCRIPTION OF AR (ANDROGEN RECEPTOR) REGULATED GENES KLK2 AND KLK3%REACTOME DATABASE ID RELEASE 57%5625886 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 15267 319183 319181 319182 319178 319186 319190 232440 319168 319167 382522 319176 76804 320795 99982 17978 624153 11835 625328 51788 15077 319188 15270 319149 319169 78303 DOWNSTREAM SIGNAL TRANSDUCTION%REACTOME%R-HSA-186763.1 Downstream signal transduction 17973 56438 26395 67603 319520 235584 26403 16416 12223 54519 100042150 21894 11600 19060 19186 19188 327826 17169 194231 109905 14161 226525 57296 67151 215449 18710 19185 66998 53380 14172 17967 15461 17463 83409 69077 29875 12912 26417 26413 12323 108058 12322 18015 59029 19197 19417 19184 19179 22190 20422 171463 14573 667035 19182 16590 240057 19181 64654 231474 14173 80903 14164 23997 66997 18039 218397 110135 14585 20848 14178 80857 228769 14180 70247 67089 20846 14586 14587 20852 14175 21762 14177 23996 20416 11876 20851 14165 26554 18596 20850 109880 16399 54153 18708 15200 640703 18706 18673 12325 16818 16706 69601 83379 22371 73902 233046 114716 12981 19415 63953 14174 12982 19252 16653 12984 240672 13537 12988 67836 16186 13385 14588 211323 16184 11836 18188 20740 20739 13645 16185 16452 216869 109689 18176 72399 70686 114715 240168 14268 66413 211255 18183 14083 16451 19192 16453 26445 19166 18218 12576 14812 76089 26444 26446 14811 26443 14813 19414 80297 14814 12575 74769 16183 20742 18707 18709 20741 21687 20743 16367 13866 14810 16192 26396 14360 16191 216148 114713 14186 19418 22123 12927 20662 19052 14170 19053 19262 73699 640524 16913 75590 19175 19177 51792 19713 19170 22330 99571 13874 103554 16912 54401 83961 56637 16188 19173 19172 21770 107971 26932 100986 226849 18611 23980 20418 26931 320484 225849 384783 12675 245684 67112 110157 19167 26441 19419 11472 19171 545987 13649 70727 18595 26442 26440 101809 18591 18750 19088 16334 76850 18753 18754 236511 19247 16337 75778 15370 18752 104110 229709 12519 12524 606496 244650 18573 12015 56717 22084 224129 77647 11513 11512 239528 12929 11515 14786 11514 12371 98432 117150 18803 56458 56484 213988 12326 11652 18717 12478 11651 12928 15937 16440 78757 228775 12487 110355 18747 18574 16438 18749 217351 210044 18575 432530 233833 23797 104111 67605 18720 17246 56716 18719 214150 108083 19087 107746 19085 18607 19084 14388 22324 17974 19211 227743 18718 109270 17454 16439 58988 TWIK RELATED POTASSIUM CHANNEL (TREK)%REACTOME DATABASE ID RELEASE 57%1299503 TWIK related potassium channel (TREK) 72258 16528 16526 TFAP2 (AP-2) FAMILY REGULATES TRANSCRIPTION OF CELL CYCLE FACTORS%REACTOME%R-HSA-8866911.1 TFAP2 (AP-2) family regulates transcription of cell cycle factors 21418 21420 17869 12575 75605 NA+ CL- DEPENDENT NEUROTRANSMITTER TRANSPORTERS%REACTOME DATABASE ID RELEASE 57%442660 Na+ Cl- dependent neurotransmitter transporters 21366 20538 240332 110877 103098 102680 20517 22598 104245 14664 56774 214084 20518 243616 74338 14411 13162 14412 232333 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION%REACTOME%R-HSA-381676.1 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion 19088 224129 11512 11514 109905 223864 14706 14696 14526 14688 16440 16500 14708 238276 14693 56508 14709 268345 240444 18747 238076 14697 29875 14699 16438 66066 18749 14700 14701 14695 14652 14704 14702 14710 64337 19087 19085 19084 16439 FUSION OF THE INFLUENZA VIRION TO THE HOST CELL ENDOSOME%REACTOME%R-HSA-168288.1 Fusion of the Influenza Virion to the Host Cell Endosome A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD%REACTOME DATABASE ID RELEASE 57%157212 A third proteolytic cleavage releases NICD 19165 59287 100039623 100042305 208117 18131 18129 18128 18132 ANTIGEN PROCESSING-CROSS PRESENTATION%REACTOME DATABASE ID RELEASE 57%1236975 Antigen processing-Cross presentation 240028 19186 19188 57296 67151 66413 19185 66998 12010 53380 19192 26445 17463 19166 69077 20333 21356 14991 12475 20619 14827 21355 117149 26444 26446 57743 26443 66212 22320 20909 240095 21354 15007 22319 13040 12317 53421 100043039 22123 59029 19184 13057 19179 22190 13039 20422 667035 19182 15006 14129 17874 12491 19181 13058 17970 23997 12229 17972 66997 17969 17533 246278 667803 17534 16913 228769 70247 19175 67089 19177 19170 21898 21762 23996 103554 16912 19173 19172 12675 21899 73902 19167 16151 17087 16419 26441 16150 19171 24088 26442 26440 21897 16410 SHC-MEDIATED CASCADE:FGFR2%REACTOME%R-HSA-5654699.1 SHC-mediated cascade:FGFR2 14165 19247 107971 327826 18176 20662 67112 64654 14173 80903 14164 14174 14178 14172 80857 14180 16653 15461 14175 14177 RRNA MODIFICATION IN THE MITOCHONDRION%REACTOME DATABASE ID RELEASE 57%6793080 rRNA modification in the mitochondrion 68017 224481 217038 69821 67390 72181 TP53 REGULATES TRANSCRIPTION OF CELL CYCLE GENES%REACTOME%R-HSA-6791312.2 TP53 Regulates Transcription of Cell Cycle Genes 69125 231464 59092 66214 328572 13197 18538 78893 12427 12028 20620 234594 52679 13496 12447 12227 104394 18983 20878 228140 219103 53621 12576 55948 232791 72068 211586 12448 19651 19650 22059 12795 58184 12575 59035 13555 21781 18148 15469 12534 52846 12566 12532 104625 29813 12428 LOSS OF FUNCTION OF SMAD4 IN CANCER%REACTOME DATABASE ID RELEASE 57%3304347 Loss of Function of SMAD4 in Cancer 17127 17128 17126 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX%REACTOME DATABASE ID RELEASE 57%937072 TRAF6 mediated induction of TAK1 complex 106759 142980 12475 225471 22190 26409 667035 17087 68652 66724 22034 66513 21898 APOPTOSIS INDUCED DNA FRAGMENTATION%REACTOME%R-HSA-140342.1 Apoptosis induced DNA fragmentation 14958 12367 80838 50708 434174 97165 13368 13347 16211 50709 14957 56702 16646 TRANSCRIPTION-COUPLED NUCLEOTIDE EXCISION REPAIR (TC-NER)%REACTOME%R-HSA-6781827.1 Transcription-Coupled Nucleotide Excision Repair (TC-NER) 72584 18973 19687 67710 69263 67967 19718 17749 66420 99375 245841 18972 108679 13194 18538 19891 69745 66467 20021 68240 69241 18971 26891 14884 56031 100043806 319955 27015 16881 12572 17420 12848 59001 72151 69833 106344 20022 66979 69920 18974 56438 231329 68275 100043714 20020 26895 22594 328572 22190 667035 66983 71101 71991 16882 26754 26893 67439 66671 57905 26894 22592 50505 13870 23894 22590 13871 13872 209357 11834 14885 13716 26572 252870 21399 28000 MISCELLANEOUS SUBSTRATES%REACTOME DATABASE ID RELEASE 57%211958 Miscellaneous substrates 56448 622127 106648 545817 100040843 72054 74134 13120 320997 631304 13118 71519 CLEAVAGE OF THE DAMAGED PYRIMIDINE%REACTOME DATABASE ID RELEASE 57%110329 Cleavage of the damaged pyrimidine 382913 17193 71726 18207 18294 72774 MITOCHONDRIAL TRANSCRIPTION TERMINATION%REACTOME%R-HSA-163316.1 Mitochondrial transcription termination 208595 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS%REACTOME%R-HSA-674695.1 RNA Polymerase II Pre-transcription Events 67710 68776 17749 66464 66420 245841 235459 209361 66467 20021 69241 20833 99730 319944 24074 108143 229906 83602 270627 20924 20922 14884 228980 12572 216185 17420 68092 69833 68705 433702 20022 69920 231329 98053 100043714 20020 107951 21374 12454 114741 24116 214498 22083 54624 66671 235497 76246 66317 68153 74197 23894 57314 27632 226182 13871 13872 58202 209357 14885 13716 72504 67655 21343 407786 67923 27224 72949 12455 21399 PAUSING AND RECOVERY OF TAT-MEDIATED HIV ELONGATION%REACTOME DATABASE ID RELEASE 57%167238 Pausing and recovery of Tat-mediated HIV elongation 107951 67710 17749 66420 245841 114741 24116 20021 20833 69241 20924 20922 57314 27632 58202 69833 13716 68705 20022 67655 69920 231329 67923 98053 27224 100043714 20020 12455 21399 GLUTATHIONE CONJUGATION%REACTOME%R-HSA-156590.2 Glutathione conjugation 14859 54486 69065 68214 68312 207182 23887 66447 14630 14862 14873 71522 14865 68044 14866 68252 14629 58810 14874 75475 14863 14854 66054 13885 100042314 14598 76263 14872 14871 211666 56615 POSITIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%R-HSA-5250913.3 Positive epigenetic regulation of rRNA expression 18519 17749 66420 12417 245841 319181 107932 234366 232440 216848 93762 23942 382522 319176 319955 433759 15182 624153 69833 625328 51788 15077 319149 18432 100043714 110052 245688 229542 66136 116870 21341 21340 15267 319183 20017 110147 21374 70333 19646 667501 328572 22130 11461 319182 319178 319186 319190 75316 64424 20016 14534 20018 81898 20019 319168 21339 319167 56637 56200 17192 22385 116871 319188 15270 319169 78303 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 57%3645790 TGFBR2 Kinase Domain Mutants in Cancer 14225 21803 21813 21812 TRIGLYCERIDE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 57%75109 Triglyceride Biosynthesis 67512 55979 99035 56348 14732 19063 12686 66775 104112 75778 106529 231510 433256 14245 54397 170439 329910 14081 14555 94180 30963 333433 78245 14104 210992 13167 20249 74559 215456 28169 243078 74205 99010 56360 74156 50790 14626 68801 54326 66834 171210 171281 69923 264895 83603 67800 14933 216739 15487 257633 171282 13350 225010 57874 170789 102247 66198 72482 233549 107476 68262 70025 68393 70757 328845 52123 54325 13358 64898 64899 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL%REACTOME%R-HSA-198933.4 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 21947 22177 27007 12266 12500 12010 246256 14991 16643 23900 17086 240095 15007 16421 20343 17470 14130 232790 75345 629970 16408 15894 78369 52855 246746 15006 328833 14129 100038830 225825 12520 84544 140497 217304 83382 12525 57781 12502 50928 667803 12501 12478 232801 12480 20612 13052 16401 52685 12483 26904 22329 12550 217306 16414 83433 15896 16641 243958 54215 224840 58217 19294 30925 54698 100043861 243864 15898 71326 217303 12526 16412 20400 270152 SIGNALING BY RHO GTPASES%REACTOME%R-HSA-194315.1 Signaling by Rho GTPases 13543 18817 67629 69928 192662 224014 269608 101497 13605 75547 26382 16800 17973 236930 68014 57257 18472 20430 56378 208628 330319 57294 13589 52696 76707 83767 242687 67733 83815 22325 76804 102920 11350 76464 320795 19046 99982 66570 83431 66713 11835 18481 108911 76499 18221 12617 75786 26886 66934 224105 259302 19353 17931 14270 13057 13058 17970 17972 12229 17969 22627 22342 117600 223666 16563 16573 319181 12237 100039786 56150 104215 232943 382522 29875 55948 22631 22629 22628 59040 26417 106628 26413 26934 13043 16319 320394 226747 66442 319183 12615 72155 108000 12236 319182 60411 319178 625534 319186 319190 232987 66468 67052 52504 67139 70385 71876 73470 320634 70454 16443 192176 12385 76117 17120 208846 232201 57778 20166 404710 13542 13544 640703 78514 16330 233071 270163 110279 100038946 228421 16886 107995 244495 12532 381318 66336 319188 67037 216965 15270 72415 56430 16594 78303 107589 17904 66977 12235 13385 26951 545156 14083 11799 12576 232345 18709 19047 19418 232906 11848 236915 20662 19052 19053 73699 51792 16572 54401 73804 21770 74764 26932 226849 12387 26931 225849 103573 229841 16593 319169 69912 54126 17283 103468 232440 234865 69736 12638 233406 319176 16709 330914 11854 20807 69288 52276 228543 73910 56419 71960 214952 80837 59015 17978 20877 223701 624153 67938 214137 625328 94190 51788 73167 15077 544963 381293 445007 75404 50768 67268 319149 228482 19386 216831 70719 263803 71085 110379 239027 105855 170758 94221 245880 19877 70497 15267 69581 50884 23912 108100 13367 56443 18643 68524 18645 11461 78816 16885 268970 329165 14787 101314 237038 236920 75669 52428 225326 19878 11855 69710 545481 19765 17886 228359 56212 226652 76884 11856 109333 19354 18479 319168 12549 11852 80987 68458 71704 71409 76709 71709 213498 17925 319167 243362 102098 12550 71893 277360 215280 214804 226970 225358 207212 11465 22379 20663 73178 11853 73341 22376 12704 68089 244867 56349 74117 224480 11308 58996 14026 74734 67771 211896 171207 11867 14570 24001 231532 75415 223435 11857 109904 218581 100039683 14569 18607 320271 17880 329251 22324 246710 109934 14567 69632 18016 212285 30938 77579 21844 76378 17207 241275 16412 230972 216445 213649 106952 53972 71302 14163 TOXICITY OF BOTULINUM TOXIN TYPE D (BONT D)%REACTOME%R-HSA-5250955.1 Toxicity of botulinum toxin type D (BoNT D) 75209 64176 22318 22317 64051 MOLYBDENUM COFACTOR BIOSYNTHESIS%REACTOME%R-HSA-947581.1 Molybdenum cofactor biosynthesis 68591 268566 69372 17434 ELEVATION OF CYTOSOLIC CA2+ LEVELS%REACTOME%R-HSA-139853.2 Elevation of cytosolic Ca2+ levels 16438 22068 26946 269717 18436 20866 231602 94045 228139 18440 22065 18438 109305 16440 18439 16439 DEFECTIVE CHST6 CAUSES MCDC1%REACTOME%R-HSA-3656225.1 Defective CHST6 causes MCDC1 14264 18295 27047 116847 16545 17022 INOSITOL PHOSPHATE METABOLISM%REACTOME%R-HSA-1483249.1 Inositol phosphate metabolism 18796 228550 18795 320404 327655 271424 74055 76500 71780 102954 269437 227399 18799 217837 16329 104759 18803 55980 234779 269180 104015 18798 18797 16331 234515 320634 16332 640703 16330 69718 72469 17330 27399 18802 233011 19211 212111 114663 56409 71207 269615 114875 75678 HIV TRANSCRIPTION ELONGATION%REACTOME DATABASE ID RELEASE 57%167169 HIV Transcription Elongation 107951 67710 17749 66420 114741 245841 24116 66467 20021 20833 69241 20924 20922 14884 66671 23894 57314 27632 12572 17420 13871 13872 58202 209357 68092 69833 14885 13716 68705 433702 20022 67655 69920 231329 98053 67923 27224 100043714 20020 12455 21399 PECAM1 INTERACTIONS%REACTOME%R-HSA-210990.1 PECAM1 interactions 15170 16416 17096 18613 19247 22612 14360 16818 16331 16410 18803 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS%REACTOME DATABASE ID RELEASE 57%264870 Caspase-mediated cleavage of cytoskeletal proteins 12368 12369 12367 11518 227753 18810 20740 14453 12370 13169 22352 AMINE COMPOUND SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 57%425428 Amine compound SLC transporters 20517 63993 243616 74338 13162 14411 14412 232333 21366 20538 240332 110877 103098 102680 22598 104245 14664 242259 56774 68682 27411 214084 58176 70129 108052 20518 56315 19743 100434 213603 ACROSOME REACTION%REACTOME%R-HSA-1300645.1 Acrosome Reaction 11434 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE%REACTOME DATABASE ID RELEASE 57%1660514 Synthesis of PIPs at the Golgi membrane 224020 64436 103199 234129 107650 234729 11842 83493 18711 75669 11840 225326 84095 18705 18704 67073 320634 DAP12 INTERACTIONS%REACTOME DATABASE ID RELEASE 57%2172127 DAP12 interactions 16822 620235 668101 12010 16643 57257 17444 22325 56438 19353 26395 67603 319520 12229 23845 235584 26403 16416 12223 22177 54519 100042150 21894 11600 19060 19186 19188 327826 17169 194231 109905 27007 14161 226525 57296 67151 215449 18710 19185 66998 53380 14172 17967 15461 17463 83409 69077 29875 12912 26417 26413 12323 108058 12322 18015 59029 19197 19417 19184 19179 22190 20422 171463 14573 667035 15006 19182 16590 240057 19181 64654 231474 217304 14173 80903 14164 23997 66997 18039 218397 667803 110135 14585 14178 80857 228769 14180 70247 67089 14586 14587 14175 21762 14177 23996 20416 11876 217306 14165 26554 18596 109880 16399 54153 18708 15200 640703 18706 18673 83433 12325 16818 16706 69601 83379 22371 73902 233046 58217 114716 12981 19415 63953 14174 12982 19252 16653 12984 240672 13537 12988 67836 16186 13385 14588 211323 16184 11836 20963 18188 20740 20739 13645 16185 16452 216869 109689 18176 72399 70686 114715 240168 14268 66413 211255 18183 14083 16451 19192 16453 26445 19166 18218 12576 14812 76089 26444 26446 14811 26443 14813 19414 80297 14814 12575 74769 16183 20742 18707 18709 20741 21687 20743 16367 13866 14810 16192 26396 14360 16191 216148 114713 14186 19418 22123 20662 19052 14170 19053 19262 73699 640524 16913 75590 19175 19177 51792 19713 19170 22330 99571 13874 103554 16912 54401 83961 56637 16188 19173 19172 21770 107971 26932 100986 226849 18611 23980 20418 26931 320484 225849 384783 12675 245684 67112 110157 19167 26441 19419 11472 19171 545987 13649 70727 18595 26442 26440 101809 18591 18750 19088 16334 76850 18753 18754 236511 19247 16337 75778 15370 18752 104110 229709 12519 12524 606496 244650 18573 12015 56717 22084 224129 77647 11513 11512 239528 11515 11514 12371 98432 117150 18803 56458 234779 56484 213988 12326 11652 18717 12478 11651 15937 16440 78757 228775 12487 110355 18747 18574 16438 18749 217351 210044 18575 432530 233833 23797 104111 67605 18720 17246 56716 18719 214150 108083 19087 19085 18607 19084 14388 22324 19211 227743 18718 109270 17454 16439 58988 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 57%383280 Nuclear Receptor transcription pathway 192292 75692 26381 26380 18667 218772 217166 19401 19411 15370 18227 22025 22260 26379 22337 22026 19016 19013 13982 19015 19014 23957 21907 13864 20182 30942 19885 353187 13983 225998 15378 19883 13865 21834 21833 11835 20183 20181 26423 ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS%REACTOME DATABASE ID RELEASE 57%181431 Acetylcholine Binding And Downstream Events 11447 11449 231252 11438 110902 110834 108015 11435 11444 110835 11440 108043 11441 11448 RECOGNITION AND ASSOCIATION OF DNA GLYCOSYLASE WITH SITE CONTAINING AN AFFECTED PURINE%REACTOME DATABASE ID RELEASE 57%110330 Recognition and association of DNA glycosylase with site containing an affected purine 70603 18294 268395 SYNTHESIS OF DOLICHYL-PHOSPHATE%REACTOME DATABASE ID RELEASE 57%446199 Synthesis of Dolichyl-phosphate 227697 67422 192156 52014 57357 57170 TRANSMISSION ACROSS CHEMICAL SYNAPSES%REACTOME DATABASE ID RELEASE 57%112315 Transmission across Chemical Synapses 12295 12297 12298 14706 14678 14696 14677 14679 20907 14688 22343 14708 14693 14709 108030 12361 14697 242851 20513 22348 12889 22318 268860 68507 20517 20512 14417 20511 63993 233977 242607 27204 20614 214579 13162 216456 20965 238276 65106 67111 67760 14660 12647 14699 66066 14700 14701 20508 327814 22342 20964 14695 19339 53310 214084 22249 14704 20510 14702 14415 20518 14710 13002 64337 319924 20979 15461 110651 18195 20111 12912 26413 20112 17161 12323 108058 12322 19417 18039 109880 17920 640703 12325 13385 11447 11449 11771 243616 14411 14412 232333 14812 14811 14813 105727 16517 12290 14814 242425 14809 12287 16519 18693 14395 12286 74053 67071 14645 14394 54393 12038 14810 21912 14397 11438 12294 56808 110834 108015 14399 14807 11444 14802 110886 54376 52589 14800 19418 14396 11448 12300 14401 55984 14402 53623 14408 16524 14407 15567 16515 16522 81905 14400 16513 243547 236915 16520 14805 14806 14406 11423 381356 11669 54377 16518 16521 328699 12846 16516 110637 14409 20130 13383 231252 110902 11435 110835 11440 108043 11441 100986 110157 11472 14680 18796 18750 18795 18752 104110 18751 18797 15481 14799 224129 11513 11512 11515 57249 11514 12326 18747 12296 18749 210044 432530 104111 17246 18607 CARGO CONCENTRATION IN THE ER%REACTOME DATABASE ID RELEASE 57%5694530 Cargo concentration in the ER 20334 235416 66890 100042773 56494 50907 218811 11839 333883 12793 13032 193813 338366 64138 69608 77371 66397 21802 214895 12794 20333 20703 70361 12836 72978 217615 56389 14275 14069 100042343 14799 99683 14067 GLYCINE DEGRADATION%REACTOME%R-HSA-6783984.1 Glycine degradation 434437 68133 104174 13382 SHC1 EVENTS IN ERBB4 SIGNALING%REACTOME DATABASE ID RELEASE 57%1250347 SHC1 events in ERBB4 signaling 56438 26395 67603 319520 235584 26403 16416 12223 54519 100042150 21894 11600 19060 19186 19188 327826 17169 194231 109905 14161 226525 57296 67151 215449 19185 66998 53380 14172 17967 15461 17463 83409 69077 29875 26417 26413 12323 108058 12322 18015 59029 19197 19417 19184 19179 22190 20422 171463 14573 667035 19182 16590 240057 19181 231474 64654 80903 14173 23997 14164 66997 18039 218397 110135 14585 14178 80857 228769 14180 70247 67089 14586 14587 14175 21762 14177 23996 20416 11876 14165 26554 18596 109880 16399 54153 15200 640703 18673 12325 16706 69601 83379 22371 73902 233046 114716 12981 19415 63953 14174 12982 19252 16653 12984 240672 13537 12988 67836 16186 13385 14588 211323 16184 11836 18188 20740 20739 13645 16185 16452 216869 109689 18176 72399 70686 114715 240168 14268 66413 211255 18183 14083 16451 19192 16453 26445 19166 18218 14812 76089 26444 26446 14811 26443 14813 19414 80297 14814 16183 20742 20741 21687 20743 16367 13866 14810 16192 26396 14360 16191 216148 114713 14186 19418 22123 20662 19052 14170 19053 19262 73699 640524 16913 75590 19175 19177 51792 19713 19170 22330 99571 13874 103554 16912 54401 83961 16188 19173 19172 21770 26932 107971 226849 100986 18611 23980 26931 20418 225849 320484 384783 245684 67112 110157 19167 26441 19419 11472 19171 545987 13649 70727 18595 26442 26440 101809 18591 CLOSTRIDIUM NEUROTOXICITY%REACTOME DATABASE ID RELEASE 57%168799 Clostridium neurotoxicity 20980 75209 64176 22318 56216 22317 20907 20614 64051 20979 ACTIVATION OF NOXA AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%R-HSA-111448.1 Activation of NOXA and translocation to mitochondria 22059 13555 21781 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI%REACTOME DATABASE ID RELEASE 57%975576 N-glycan antennae elongation in the medial trans-Golgi 217664 53618 17309 71665 103534 20450 14595 107895 98388 67569 17158 56386 68947 57370 56375 241230 53418 12640 20451 56336 20443 269181 16866 20440 PROTEIN REPAIR%REACTOME DATABASE ID RELEASE 57%5676934 Protein repair 22166 320183 18537 110265 76467 27361 INTERLEUKIN-6 SIGNALING%REACTOME%R-HSA-1059683.2 Interleukin-6 signaling 16194 16195 16193 19247 20848 54721 16451 16452 12702 12402 GSD 0%REACTOME%R-HSA-3858516.1 GSD 0 232493 APC-CDC20 MEDIATED DEGRADATION OF NEK2A%REACTOME%R-HSA-179409.1 APC-Cdc20 mediated degradation of Nek2A 66156 52206 668450 22190 12236 12237 22194 667035 52563 56150 99152 59008 56317 75430 18005 216080 107995 217232 69957 52717 68999 68612 17222 RA BIOSYNTHESIS PATHWAY%REACTOME%R-HSA-5365859.2 RA biosynthesis pathway 241452 546726 28200 108841 13082 19378 11668 26876 232174 19682 242285 56847 105349 11522 237320 20148 12903 98711 216454 105014 17252 AMPK INHIBITS CHREBP TRANSCRIPTIONAL ACTIVATION ACTIVITY%REACTOME%R-HSA-163680.2 AMPK inhibits chREBP transcriptional activation activity 108079 108099 108097 68465 11450 20869 72674 58805 CONJUGATION OF CARBOXYLIC ACIDS%REACTOME%R-HSA-159424.1 Conjugation of carboxylic acids 233801 117147 272428 107146 233799 435528 ASSEMBLY OF THE HIV VIRION%REACTOME DATABASE ID RELEASE 57%175474 Assembly Of The HIV Virion 268373 52348 194309 66914 330192 18108 18550 22088 22190 107305 667035 FRS-MEDIATED FGFR4 SIGNALING%REACTOME%R-HSA-5654712.1 FRS-mediated FGFR4 signaling 56438 26395 67603 319520 235584 26403 16416 12223 54519 100042150 21894 11600 19060 19186 19188 327826 17169 194231 109905 14161 226525 57296 67151 215449 19185 66998 53380 14172 17967 15461 17463 83409 69077 29875 26417 26413 12323 108058 12322 18015 59029 19197 19417 19184 19179 22190 20422 171463 14573 667035 19182 16590 240057 19181 231474 64654 80903 14173 23997 14164 66997 18039 218397 110135 14585 14178 80857 228769 14180 70247 67089 14586 14587 14175 21762 14177 23996 20416 11876 14165 26554 18596 109880 16399 54153 15200 640703 18673 12325 16706 69601 83379 22371 73902 233046 114716 12981 19415 63953 14174 12982 19252 16653 12984 240672 13537 12988 67836 16186 13385 14588 211323 16184 11836 18188 20740 20739 13645 16185 16452 216869 109689 18176 72399 70686 114715 240168 14268 66413 211255 18183 14083 16451 19192 16453 26445 19166 18218 14812 76089 26444 26446 14811 26443 14813 19414 80297 14814 16183 20742 20741 21687 20743 16367 13866 14810 16192 26396 14360 16191 216148 114713 14186 19418 22123 20662 19052 14170 19053 19262 73699 640524 16913 75590 19175 19177 51792 19713 19170 22330 99571 13874 103554 16912 54401 83961 16188 19173 19172 21770 26932 107971 226849 100986 18611 23980 26931 20418 225849 320484 384783 245684 67112 110157 19167 26441 19419 11472 19171 545987 13649 70727 18595 26442 26440 101809 18591 19247 FGFR1C AND KLOTHO LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 57%190374 FGFR1c and Klotho ligand binding and activation 64654 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER%REACTOME%R-HSA-5696397.1 Gap-filling DNA repair synthesis and ligation in GG-NER 22594 18973 19687 69263 27015 67967 16881 19718 22190 18972 18538 667035 19891 69745 68240 18971 16882 59001 72151 106344 66979 18974 68275 CHYLOMICRON-MEDIATED LIPID TRANSPORT%REACTOME%R-HSA-174800.4 Chylomicron-mediated lipid transport 56453 68453 18550 18453 18553 17777 270669 11806 66397 11808 100017 66113 11813 56636 238055 11807 18552 15450 208677 16956 11814 624219 57875 30924 16835 11816 SYNTHESIS OF HEPOXILINS (HX) AND TRIOXILINS (TRX)%REACTOME DATABASE ID RELEASE 57%2142696 Synthesis of Hepoxilins (HX) and Trioxilins (TrX) 11684 P53-INDEPENDENT DNA DAMAGE RESPONSE%REACTOME%R-HSA-69610.1 p53-Independent DNA Damage Response 19186 19188 57296 67151 66413 19185 11920 66998 53380 19192 17463 26445 19166 69077 26444 26446 26443 22123 59029 19184 19179 22190 20422 667035 19182 19181 23997 66997 16913 228769 70247 19175 67089 19177 19170 21762 23996 103554 16912 19173 19172 73902 19167 50883 26441 12530 19171 12649 26442 26440 TOLERANCE OF REACTIVE OXYGEN PRODUCED BY MACROPHAGES%REACTOME DATABASE ID RELEASE 57%1222387 Tolerance of reactive oxygen produced by macrophages IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX%REACTOME DATABASE ID RELEASE 57%200425 Import of palmitoyl-CoA into the mitochondrial matrix 100705 108079 12895 108099 12896 57279 108097 12894 107476 19015 20181 DEFECTIVE GALNT3 CAUSES FAMILIAL HYPERPHOSPHATEMIC TUMORAL CALCINOSIS (HFTC)%REACTOME DATABASE ID RELEASE 57%5083625 Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC) 17829 224116 269328 100039649 353328 73732 17063 140474 HISTAMINE RECEPTORS%REACTOME%R-HSA-390650.1 Histamine receptors 15466 99296 15465 225192 TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING%REACTOME%R-HSA-975110.1 TRAF6 mediated IRF7 activation in TLR7 8 or 9 signaling 81897 266632 170743 54123 170744 22034 66589 93765 72162 17874 16179 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE%REACTOME DATABASE ID RELEASE 57%181438 Toll Like Receptor 2 (TLR2) Cascade 19094 11596 110651 12475 20210 117149 12234 17164 72349 26965 20111 12912 26400 26417 240518 26413 23939 20112 257632 266632 26420 107607 11909 16476 17260 13712 434174 22190 26414 108960 26395 26409 26401 667035 26398 26397 192656 17874 12491 67603 19052 100040260 19053 319520 73699 12229 26419 68652 11820 21402 66724 102626 22034 20203 66513 17258 24058 93765 12703 51792 26940 103583 21898 73914 26416 21770 12675 19697 21899 18033 26399 18036 231130 18035 17087 16151 18034 73086 16150 67245 93834 13211 66589 14281 24088 26410 21897 235584 16179 TOXICITY OF BOTULINUM TOXIN TYPE E (BONT E)%REACTOME%R-HSA-5250992.1 Toxicity of botulinum toxin type E (BoNT E) 64176 20614 64051 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS%REACTOME DATABASE ID RELEASE 57%983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers 58194 20963 12402 229709 18803 20662 234779 22063 20866 12229 12478 109305 16440 12483 17973 16438 15170 17096 17060 83490 15985 18708 208650 12518 26377 640703 269717 12143 18707 22324 14360 16439 20811 RESPONSE TO METAL IONS%REACTOME DATABASE ID RELEASE 57%5660526 Response to metal ions 17748 17752 17750 17751 PI-3K CASCADE:FGFR3%REACTOME DATABASE ID RELEASE 57%5654710 PI-3K cascade:FGFR3 211323 13645 18183 12576 12575 74769 18707 18709 16367 13866 14360 14186 19052 14170 19053 73699 51792 13874 56637 83961 21770 26932 226849 26931 225849 384783 12675 67112 13649 18595 18591 12223 16334 76850 100042150 236511 19247 16337 75778 15370 327826 12519 12524 18710 14172 12912 26417 26413 606496 244650 12015 56717 22084 77647 239528 12371 98432 16590 117150 64654 56458 14173 56484 80903 14164 213988 11652 18717 12478 11651 15937 14178 80857 14180 78757 228775 12487 14175 14177 217351 14165 18596 233833 23797 18708 15200 67605 18706 18720 17246 56716 16818 18719 214150 108083 83379 18607 14388 22324 14174 19211 227743 18718 109270 17454 58988 NUCLEAR ENVELOPE BREAKDOWN%REACTOME%R-HSA-2980766.1 Nuclear Envelope Breakdown 218210 18750 66679 18226 69912 227720 18817 22367 54563 223921 103468 14245 70699 72787 18751 64898 217718 59125 16906 269113 231042 234865 59126 69736 19069 107939 170762 382030 59015 227699 64899 67181 12534 18141 445007 12442 108989 19386 380664 69482 224640 71805 23825 13726 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP)%REACTOME%R-HSA-400511.1 Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) 14463 16392 56529 69019 13482 14607 66286 236781 18508 18548 233081 66624 76687 HDR THROUGH SINGLE STRAND ANNEALING (SSA)%REACTOME%R-HSA-5685938.1 HDR through Single Strand Annealing (SSA) 17535 69263 12021 19718 19891 68240 12189 11920 231724 237911 327762 50505 21975 19360 13870 19365 19355 235610 81601 11350 19367 225182 19361 27354 72151 15574 106344 22427 68275 19356 12144 26909 235559 MISMATCH REPAIR (MMR) DIRECTED BY MSH2:MSH3 (MUTSBETA)%REACTOME DATABASE ID RELEASE 57%5358606 Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) 18861 67967 16881 17350 17685 18972 18538 19891 69745 68240 18971 17686 68275 26909 INSULIN EFFECTS INCREASED SYNTHESIS OF XYLULOSE-5-PHOSPHATE%REACTOME%R-HSA-163754.1 Insulin effects increased synthesis of Xylulose-5-Phosphate 21881 21351 REGULATION OF APOPTOSIS%REACTOME DATABASE ID RELEASE 57%169911 Regulation of Apoptosis 59029 19184 22190 19179 20422 19186 19188 667035 19182 19181 57296 23997 67151 66997 66413 19185 66998 53380 16913 228769 19192 70247 19175 19177 67089 26445 17463 19166 19170 69077 21762 23996 103554 16912 26444 26446 19173 26443 19172 78514 73902 19167 26441 19171 26442 26440 22123 224105 UNWINDING OF DNA%REACTOME DATABASE ID RELEASE 57%176974 Unwinding of DNA 12544 17215 17219 17217 66634 109145 272551 17216 78833 69270 17220 17218 PROCESSING AND ACTIVATION OF SUMO%REACTOME DATABASE ID RELEASE 57%3215018 Processing and activation of SUMO 50995 56459 75826 22196 100043429 320213 223870 20610 RECYCLING PATHWAY OF L1%REACTOME DATABASE ID RELEASE 57%437239 Recycling pathway of L1 16571 11772 20404 74947 11771 67300 71770 13429 110651 16728 20111 12757 232910 11773 13430 26413 20112 103967 67071 56613 73086 22350 17698 19684 12934 18222 71653 PLC BETA MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 57%112043 PLC beta mediated events 18750 18796 18573 19088 18795 18753 224129 11513 11512 11515 11514 18752 104110 229709 12326 14678 14677 14679 16440 18798 18797 110355 18747 18574 16438 18749 210044 18575 432530 18783 104111 12912 640703 26413 19087 19085 19084 242851 14681 14685 14686 14687 16439 SIGNALING BY BMP%REACTOME DATABASE ID RELEASE 57%201451 Signaling by BMP 12166 12168 66313 17130 17131 55994 17125 17129 17128 11481 218441 75788 14314 23893 20481 12156 216080 66105 12622 12167 11480 18121 FCERI MEDIATED NF-KB ACTIVATION%REACTOME%R-HSA-2871837.2 FCERI mediated NF-kB activation 108723 19186 19188 100041766 216080 57296 67151 66413 19185 66998 53380 12042 19395 19192 26445 17463 19166 216150 69077 17096 26444 12234 26446 26443 26965 22123 59029 19184 22190 19179 20422 26409 667035 19182 19181 23997 66997 68652 66724 21402 22034 66513 16913 240354 228769 93765 70247 19175 67089 19177 103583 19170 21762 23996 103554 16912 19173 19172 18761 12675 19697 18033 73902 18035 18607 19167 233046 16151 26441 19419 16150 19171 66589 26442 26440 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX%REACTOME%R-HSA-141430.1 Inactivation of APC C via direct inhibition of the APC C complex 66156 52206 668450 12236 12237 22194 52563 56150 59008 99152 56317 75430 216080 107995 69957 217232 52717 68999 68612 17222 DEPYRIMIDINATION%REACTOME%R-HSA-73928.1 Depyrimidination 382913 17193 71726 18207 18294 72774 GLYCEROPHOSPHOLIPID BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 57%1483206 Glycerophospholipid biosynthesis 26971 18784 14792 78390 218121 23945 14245 18779 225845 18782 66350 329502 18778 271844 99010 26970 26565 18807 53357 12038 11423 12647 242259 68682 70129 100434 213603 67512 55979 14732 231510 14555 333433 210992 215456 28169 75320 28042 12651 102278 13026 18618 18783 19210 212862 66586 71760 12660 67800 66853 99712 66857 270084 236899 116939 13350 105501 225010 237928 232889 102247 67452 668257 320951 14712 231086 68262 66826 97212 106861 52123 665270 218865 12891 77582 226856 52858 66727 104759 266692 18805 110911 27281 18806 27388 64898 70568 68671 114874 245532 74451 74596 74182 110695 66461 192166 67216 237625 74129 12116 56305 64899 HEDGEHOG 'OFF' STATE%REACTOME DATABASE ID RELEASE 57%5610787 Hedgehog 'off' state 73916 213081 19088 271639 81896 21821 106633 73668 67661 19186 22158 19188 245866 104110 70300 380614 380718 57296 67151 66413 19185 237222 66998 53380 19192 26445 17463 19166 69077 26444 12234 26446 26443 26965 14632 240888 19206 14634 319757 56438 18222 244585 110350 74682 22123 59029 224129 19184 11513 19179 22190 11512 20422 11515 667035 11514 19182 19181 23997 24069 66997 14633 21402 16396 16913 228769 70247 19175 67089 19177 19170 21762 18747 23996 16568 18749 103554 16912 210044 56637 93687 432530 19173 19172 104111 19087 19085 73902 19167 19084 26441 19171 26442 26440 RELEASE OF HH-NP FROM THE SECRETING CELL%REACTOME DATABASE ID RELEASE 57%5362798 Release of Hh-Np from the secreting cell 13363 11491 20423 103978 16147 77583 214240 TWIK-RELATED SPINAL CORD K+ CHANNEL (TRESK)%REACTOME%R-HSA-1299344.1 TWIK-related spinal cord K+ channel (TRESK) 332396 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING%REACTOME DATABASE ID RELEASE 57%1358803 Downregulation of ERBB2:ERBB3 signaling 211323 11652 13866 100042150 67588 23797 11651 22190 84092 667035 ACTIVATION OF NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME DATABASE ID RELEASE 57%629602 Activation of Nicotinic Acetylcholine Receptors 11447 11449 231252 11438 110902 110834 108015 11435 11444 110835 11440 108043 11441 11448 GAP JUNCTION DEGRADATION%REACTOME DATABASE ID RELEASE 57%190873 Gap junction degradation 67300 74325 14609 17920 13429 12757 13132 11773 13430 SYNTHESIS OF PIPS AT THE ER MEMBRANE%REACTOME DATABASE ID RELEASE 57%1483248 Synthesis of PIPs at the ER membrane 224020 83493 67073 ELECTRON TRANSPORT FROM NADPH TO FERREDOXIN%REACTOME DATABASE ID RELEASE 57%2395516 Electron transport from NADPH to Ferredoxin 68165 14148 14149 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK%REACTOME%R-HSA-380972.1 Energy dependent regulation of mTOR by LKB1-AMPK 56717 22084 108099 19079 108097 19082 83409 108079 19042 64930 241113 12283 72149 66096 56716 74370 54170 245670 545987 68576 20869 68441 66508 227154 52187 69008 105787 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS%REACTOME DATABASE ID RELEASE 57%1222352 Latent infection of Homo sapiens with Mycobacterium tuberculosis 17002 EUKARYOTIC TRANSLATION TERMINATION%REACTOME DATABASE ID RELEASE 57%72764 Eukaryotic Translation Termination 235606 67768 76808 68028 100043755 19899 67186 20115 57294 667739 67025 27370 65019 67248 666669 100038991 100038875 100040021 14852 225363 14853 432502 66481 100040298 238217 56040 667618 19989 67891 100042986 100042740 621100 100043295 67097 100043000 625646 67281 633683 667035 666899 16785 100039316 267019 100040970 19941 382492 20055 19951 100042670 68193 665189 668182 19921 20044 668144 100043423 100043893 670832 100043876 629957 225058 22121 75617 667279 76846 27050 67674 100043184 19934 100040331 100043391 319195 68172 241053 100043209 20102 67941 27207 668668 20103 672214 622534 20085 20084 TRANSPORT OF FATTY ACIDS%REACTOME DATABASE ID RELEASE 57%804914 Transport of fatty acids 11815 77701 26569 26457 225579 77704 N-GLYCAN ANTENNAE ELONGATION%REACTOME DATABASE ID RELEASE 57%975577 N-Glycan antennae elongation 103534 20450 14595 107895 67569 56386 57370 56375 241230 53418 56336 20451 20443 269181 20440 TNFS BIND THEIR PHYSIOLOGICAL RECEPTORS%REACTOME DATABASE ID RELEASE 57%5669034 TNFs bind their physiological receptors 18383 245527 21937 85030 24099 230979 21938 14103 21943 57916 13608 16992 21936 21940 50930 69583 21948 240873 171211 21935 326623 22164 22163 13607 GAB1 SIGNALOSOME%REACTOME%R-HSA-180292.1 GAB1 signalosome 211323 13645 18183 12576 12575 74769 18707 18709 16367 13866 14360 14186 19303 19052 14170 19053 73699 51792 13874 56637 83961 21770 26932 226849 26931 225849 384783 12675 67112 13649 18595 18591 12223 16334 76850 100042150 236511 19247 16337 75778 15370 327826 94212 12519 12524 18710 14172 12912 26417 26413 606496 244650 12015 56717 22084 77647 239528 12371 98432 16590 117150 64654 56458 14173 56484 80903 14164 213988 11652 18717 12478 11651 15937 14178 80857 14180 78757 228775 12487 14175 14177 217351 14165 18596 233833 23797 18708 15200 67605 18706 18720 17246 56716 16818 18719 214150 108083 83379 18607 14388 22324 14174 19211 227743 18718 109270 17454 12988 58988 MITOTIC METAPHASE AND ANAPHASE%REACTOME%R-HSA-2555396.1 Mitotic Metaphase and Anaphase 18817 22367 67629 26951 69928 105988 66413 19192 26445 19166 11799 236930 68014 71978 26444 18472 26446 208628 57294 26443 13589 52696 67849 76707 67733 83815 102920 76464 218914 66570 83431 108911 76499 18221 12617 19047 75786 26886 66934 224640 13726 22123 19052 19053 73699 16913 19175 19177 51792 19170 103554 16912 19173 73804 21770 19172 26932 226849 26931 103573 225849 19167 26441 19171 229841 26442 26440 23825 66156 69912 16563 52206 668450 12237 22194 19186 103468 19188 56150 75430 216080 57296 67151 19185 66998 53380 52717 17463 234865 69736 69077 52276 13006 52563 99152 19357 59015 20877 20842 16319 445007 69957 68999 19386 68612 17222 110379 320394 226747 66442 12615 59029 72155 108000 19184 12236 22190 19179 60411 20422 625534 667035 232987 19182 66468 19181 67052 52504 23997 66997 67139 71782 71521 16906 228769 70385 70247 71876 67089 73470 100710 21762 70454 23996 24061 17120 20843 67141 59008 228421 56317 73902 244495 107995 381318 66336 217232 67037 216965 72415 56430 380664 30939 66977 12235 EUKARYOTIC TRANSLATION ELONGATION%REACTOME%R-HSA-156842.1 Eukaryotic Translation Elongation 13628 76808 68028 100043755 19899 67186 20115 57294 667739 67025 27370 65019 67248 666669 100038991 100038875 100040021 432502 66481 100040298 238217 56040 667618 19989 67891 100042986 100042740 621100 100043295 67097 13629 100043000 625646 67281 633683 666899 667035 16785 100039316 267019 100040970 19941 382492 20055 19951 100042670 68193 665189 55949 668182 19921 20044 668144 100043423 100043893 670832 100043876 629957 225058 22121 75617 667279 76846 27050 100043184 19934 66656 100040331 100043391 319195 68172 67160 241053 100043209 20102 67941 27207 668668 20103 672214 622534 20085 20084 CLEC7A INFLAMMASOME PATHWAY%REACTOME DATABASE ID RELEASE 57%5660668 CLEC7A inflammasome pathway 18033 66824 240354 16176 12370 19697 SUMOYLATION%REACTOME DATABASE ID RELEASE 57%2990846 SUMOylation 13619 218210 56459 66679 18226 241915 69912 56233 54383 227720 54563 223921 18538 103468 21974 70699 67711 72787 15204 240087 12189 21973 21969 269113 231042 67241 234865 20878 69736 26370 20610 15381 19069 107939 70238 11799 170762 12578 75826 27223 11545 19821 52276 18854 22059 13006 20687 55989 214669 21420 19357 22658 21419 59015 20877 227699 18141 20842 59004 66647 22427 16319 445007 68275 108989 19386 12144 69482 71805 68501 116870 12418 223870 30951 100043429 320213 226026 22591 229615 24061 22196 19365 20843 19763 17246 12416 17342 67872 50995 56469 108138 12151 66341 15387 TRANSCRIPTION OF THE HIV GENOME%REACTOME%R-HSA-167172.1 Transcription of the HIV genome 67897 67710 24018 68776 17749 66464 66420 245841 235459 209361 66467 20021 69241 20833 99730 319944 24074 108143 229906 83602 270627 20924 20922 14884 228980 12572 216185 17420 68092 69833 68705 433702 20022 69920 231329 98053 100043714 20020 107951 21374 12454 114741 24116 66671 68153 74197 23894 57314 27632 226182 13871 13872 58202 209357 14885 13716 72504 67655 21343 407786 67923 27224 72949 12455 21399 LYSOSOMAL OLIGOSACCHARIDE CATABOLISM%REACTOME%R-HSA-8853383.1 Lysosomal oligosaccharide catabolism 73744 17160 110173 17159 G2 M TRANSITION%REACTOME DATABASE ID RELEASE 57%69275 G2 M Transition 76816 18817 77744 56455 76478 71909 219072 66413 214552 237222 20873 18536 104318 19192 22145 73738 26445 20878 19166 26370 74470 219103 17997 99100 74360 71978 68121 26444 18472 26446 27373 12009 26443 26965 13589 54130 76707 230376 12572 66296 12575 236266 17420 78887 18005 19046 15519 381644 22154 225745 214444 28135 231123 13427 13424 83922 208518 75786 18541 103733 101565 78177 22123 17274 69654 22153 225659 71648 16475 227613 19646 328572 17931 16328 53598 22142 68475 19052 19053 73699 21402 16913 19175 22627 51792 19177 103583 66671 19170 103554 16912 103768 51885 19173 75660 19172 100986 103573 629959 74237 19167 15366 26441 19171 231506 259279 12537 101706 26442 56299 26440 72568 21664 233276 19088 22390 19186 19188 14235 57296 67151 19185 66998 53380 17463 69077 12234 22059 22628 12531 12534 12566 12442 59029 72119 108000 19184 19179 22190 20422 667035 19182 12427 268930 19181 15516 23997 66997 228769 70247 67089 21762 18747 23996 29870 17865 75296 73902 12532 12530 12428 HEME BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 57%189451 Heme biosynthesis 15288 22275 12892 17025 226139 22276 14151 70383 19044 11655 11656 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%R-HSA-3315487.1 SMAD2 3 MH2 Domain Mutants in Cancer 17127 17128 17126 21803 21813 21812 ORC1 REMOVAL FROM CHROMATIN%REACTOME%R-HSA-68949.1 Orc1 removal from chromatin 19186 19188 57296 67151 66413 19185 66998 53380 18392 19192 26428 18393 26445 17463 26429 19166 69077 12576 26444 26446 26443 19645 12575 12566 22123 59029 19184 22190 19179 20422 667035 56371 19182 12427 19181 23997 66997 16913 228769 50793 19175 70247 19177 67089 19170 21762 23996 17215 17219 103554 17217 16912 56452 19173 66634 19172 67177 73902 19167 26441 23834 19171 17216 26442 26440 17220 12428 17218 IKBKB DEFICIENCY CAUSES SCID%REACTOME DATABASE ID RELEASE 57%5602636 IKBKB deficiency causes SCID 16151 12675 PP2A-MEDIATED DEPHOSPHORYLATION OF KEY METABOLIC FACTORS%REACTOME DATABASE ID RELEASE 57%163767 PP2A-mediated dephosphorylation of key metabolic factors 19052 18639 19053 73699 21770 51792 58805 VIRUS ASSEMBLY AND RELEASE%REACTOME%R-HSA-168268.1 Virus Assembly and Release 12330 12317 METALLOTHIONEINS BIND METALS%REACTOME%R-HSA-5661231.2 Metallothioneins bind metals 17748 17752 17750 17751 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS%REACTOME DATABASE ID RELEASE 57%176187 Activation of ATR in response to replication stress 70024 69263 19718 19891 68240 27214 18392 50793 26428 18393 26429 231724 17215 17219 17217 56452 66634 19355 235610 19367 12544 72151 15574 12545 106344 12566 23834 269582 12532 12530 68275 19356 17216 12649 17220 17218 APOPTOTIC FACTOR-MEDIATED RESPONSE%REACTOME%R-HSA-111471.1 Apoptotic factor-mediated response 11783 12369 12367 670717 11798 12371 66593 SYNTHESIS OF 5-EICOSATETRAENOIC ACIDS%REACTOME DATABASE ID RELEASE 57%2142688 Synthesis of 5-eicosatetraenoic acids 11690 625249 17001 11689 14775 14776 SUMOYLATION OF DNA REPLICATION PROTEINS%REACTOME DATABASE ID RELEASE 57%4615885 SUMOylation of DNA replication proteins 218210 66679 18226 69912 227720 54563 18538 223921 21974 103468 70699 72787 21973 100043429 21969 269113 231042 20878 234865 69736 20610 19069 229615 107939 11799 170762 22196 52276 59015 20877 227699 18141 59004 16319 445007 108989 19386 69482 71805 BETA OXIDATION OF OCTANOYL-COA TO HEXANOYL-COA%REACTOME%R-HSA-77348.1 Beta oxidation of octanoyl-CoA to hexanoyl-CoA 15107 93747 11364 231086 97212 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA%REACTOME DATABASE ID RELEASE 57%159230 Transport of the SLBP Dependant Mature mRNA 218210 66679 18226 69912 227720 54563 223921 103468 70699 72787 13684 53319 269113 231042 234865 69736 19069 107939 170762 59015 20492 68092 227699 18141 433702 445007 108989 19386 21681 69482 71805 GLYCOSAMINOGLYCAN METABOLISM%REACTOME DATABASE ID RELEASE 57%1630316 Glycosaminoglycan metabolism 231583 14734 15118 15478 212898 15476 195646 15116 17423 50787 70484 27029 64580 110006 11603 23972 23971 56386 57370 56375 53418 56336 11881 218271 328779 233781 628779 14735 338362 280645 80982 20544 114332 15531 23908 54371 319415 83398 108652 15587 12505 108902 227327 50785 15212 54710 117592 15211 27419 56398 15586 72136 14043 56773 12091 545291 14042 109685 14595 319901 76969 72297 15931 93683 27416 15442 50786 15117 76898 72727 73836 71951 15932 217119 23888 13521 15366 14733 103978 231727 14264 18295 27047 116847 16545 17022 78923 121021 74241 269941 58250 13004 12111 29873 60322 77590 13179 234356 71797 59031 13003 53374 78752 53625 12032 20971 75612 20969 15530 54613 192188 20970 15529 20442 20443 20444 ALKBH2 MEDIATED REVERSAL OF ALKYLATION DAMAGE%REACTOME%R-HSA-112122.1 ALKBH2 mediated reversal of alkylation damage 231642 TRANSFERRIN ENDOCYTOSIS AND RECYCLING%REACTOME DATABASE ID RELEASE 57%917977 Transferrin endocytosis and recycling 68428 66290 21871 108664 27060 73834 140494 100039636 11974 22041 242341 22042 74051 114143 11966 11975 68775 11972 66237 54411 11973 11964 110935 66144 94178 338375 66335 76252 74915 DEFECTIVE B3GAT3 CAUSES JDSSDHD%REACTOME%R-HSA-3560801.1 Defective B3GAT3 causes JDSSDHD 15530 14734 14735 13003 12032 20971 103978 20969 11603 20970 121021 15529 13004 12111 29873 14733 71951 13179 23888 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1%REACTOME DATABASE ID RELEASE 57%1810476 RIP-mediated NFkB activation via ZBP1 11596 106759 142980 20210 56532 434174 19766 17874 12675 19697 18033 18036 18035 16151 18034 16150 11820 13211 20203 58203 DEPOLYMERISATION OF THE NUCLEAR LAMINA%REACTOME%R-HSA-4419969.1 Depolymerisation of the Nuclear Lamina 18750 18751 64899 12534 67181 64898 382030 16906 380664 14245 224640 13726 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER%REACTOME DATABASE ID RELEASE 57%76061 RNA Polymerase III Transcription Initiation From Type 1 Promoter 17749 21374 66420 245841 20016 26939 70408 67486 12909 78929 20018 67065 67005 218832 69870 70428 74414 544971 233863 66596 71752 72308 69833 70239 269252 67371 100043714 98488 SODIUM PROTON EXCHANGERS%REACTOME%R-HSA-425986.1 Sodium Proton exchangers 236727 331004 77031 20544 236794 105243 277973 226999 110895 DEFECTIVE PRO-SFTPC CAUSES PULMONARY SURFACTANT METABOLISM DYSFUNCTION 2 (SMDP2) AND RESPIRATORY DISTRESS SYNDROME (RDS)%REACTOME DATABASE ID RELEASE 57%5688354 Defective pro-SFTPC causes pulmonary surfactant metabolism dysfunction 2 (SMDP2) and respiratory distress syndrome (RDS) 20389 20388 HUR (ELAVL1) BINDS AND STABILIZES MRNA%REACTOME DATABASE ID RELEASE 57%450520 HuR (ELAVL1) binds and stabilizes mRNA 18750 11737 15568 671392 18753 69583 227720 103573 PYRIMIDINE CATABOLISM%REACTOME DATABASE ID RELEASE 57%73621 Pyrimidine catabolism 23959 64705 22271 72962 50773 230718 99586 103850 103149 268782 76654 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1%REACTOME DATABASE ID RELEASE 57%450321 JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 26420 107607 26414 108960 26409 26400 26398 192656 16151 68652 26419 66724 257632 22034 66513 16179 CALMODULIN INDUCED EVENTS%REACTOME DATABASE ID RELEASE 57%111933 Calmodulin induced events 18750 19088 18573 18753 224129 11513 11512 11515 18752 11514 104110 12326 110355 18747 18574 18749 210044 18575 432530 104111 640703 12912 19087 19085 19084 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME DATABASE ID RELEASE 57%2660825 Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant 54485 11487 13388 16450 16449 11491 18128 TNFR2 NON-CANONICAL NF-KB PATHWAY%REACTOME%R-HSA-5668541.1 TNFR2 non-canonical NF-kB pathway 72049 21947 53859 17000 21934 22031 19186 24099 19188 21943 11797 16992 27279 50930 57296 67151 21944 66413 11796 19185 66998 16994 21948 53380 240873 19192 171211 21935 26445 17463 326623 19166 22164 69077 22163 13607 26444 12234 26446 26443 26965 22192 69583 22123 22200 22030 59029 19184 19179 22190 20422 21937 21926 14103 667035 19182 19181 23997 66997 21402 16913 228769 70247 19175 67089 19177 103583 19170 21762 23996 18383 103554 16912 19173 19172 245527 85030 230979 21938 57916 13608 21936 12675 21940 73902 19167 26441 18034 19698 19171 26442 26440 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS%REACTOME DATABASE ID RELEASE 57%75876 Synthesis of very long-chain fatty acyl-CoAs 56348 19063 12686 66775 106529 433256 54397 170439 14081 94180 30963 74559 243078 74205 50790 68801 54326 83603 216739 15487 257633 57874 70757 328845 54325 MYOGENESIS%REACTOME DATABASE ID RELEASE 57%525793 Myogenesis 57810 17260 21406 17928 17261 21413 29857 12555 17927 17877 19094 12558 18209 17259 17258 12386 18007 12561 12175 17878 70834 21423 12385 26416 12387 11350 26399 METABOLISM OF FAT-SOLUBLE VITAMINS%REACTOME%R-HSA-6806667.1 Metabolism of fat-soluble vitamins 109791 14734 68453 103978 11603 65969 11806 69568 11808 27973 71707 11813 238055 17252 11807 14735 69060 19141 16956 77337 11814 105349 16835 665270 11816 19659 63857 65107 13081 79235 67861 244209 55938 20971 20969 83702 19662 19660 13115 239393 170752 14725 14473 71951 23888 15530 22139 16971 20970 15529 14733 MACROAUTOPHAGY%REACTOME DATABASE ID RELEASE 57%1632852 Macroautophagy 56455 108099 19079 108097 19082 75608 83409 68097 66734 67443 74370 56717 97287 22084 93739 66615 67841 52639 68953 75669 225326 67526 74302 56208 11793 108079 64930 241113 66700 666468 22241 78610 66096 77040 105513 56716 56486 242557 208092 74781 12421 66795 228361 54170 235040 245670 218978 545987 68576 66371 68118 245860 74244 68441 57436 66508 51897 52187 213948 54636 105787 66840 COMPLEMENT CASCADE%REACTOME%R-HSA-166658.1 Complement cascade 69379 71693 239447 110382 319430 12279 12260 230558 667277 317677 12944 12274 12273 333883 109828 12628 15139 19128 17221 12266 12267 625018 12263 12630 16904 22370 14962 11537 12759 12259 17195 14134 12262 RESOLUTION OF D-LOOP STRUCTURES%REACTOME%R-HSA-5693537.1 Resolution of D-Loop Structures 17535 12021 74335 12189 11920 237911 12190 52864 233826 327762 268465 19364 21975 19360 114714 57434 224008 209334 81601 19362 71711 19363 225182 269400 27354 19361 22427 12144 26909 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY%REACTOME%R-HSA-3359457.1 Defective GIF causes intrinsic factor deficiency 14603 SIGNALING BY INTERLEUKINS%REACTOME DATABASE ID RELEASE 57%449147 Signaling by Interleukins 12402 20907 17096 20909 77125 56438 16176 266632 107607 26395 26398 192656 17874 67603 319520 93765 103583 73914 26399 231130 67245 93834 66589 26410 235584 16179 26403 16416 12223 54519 100042150 12504 21894 11600 19060 19186 19188 327826 17169 194231 109905 14161 226525 57296 67151 215449 18710 19185 66998 53380 14172 17967 15461 17463 83409 69077 29875 12234 22631 26417 240518 26413 257632 12323 108058 12322 18015 59029 19197 19417 19184 19179 22190 20422 108960 171463 26409 14573 667035 19182 16590 240057 19181 231474 64654 80903 14173 23997 14164 66997 18039 68652 218397 66724 110135 22034 14585 66513 14178 20848 228769 80857 70247 14180 67089 14586 14587 21762 14175 23996 14177 20416 11876 20851 14165 26554 17060 18596 20850 109880 14389 16399 54153 18708 15200 640703 18706 18673 12325 16818 16706 69601 83379 22371 73902 233046 114716 12981 19415 63953 14174 12982 19252 16653 12984 240672 13537 12988 21682 67836 16186 13385 14588 211323 16184 11836 20963 18188 20740 20739 13645 16185 16452 216869 109689 18176 72399 70686 114715 240168 14268 66413 211255 18183 14083 16451 19192 16453 12702 26445 19166 16331 18218 15170 16195 16194 14812 16193 76089 16332 26444 26446 14811 19374 26443 26965 19373 14813 19414 54721 80297 14814 74769 16183 20742 18707 18709 20741 21687 20743 16367 13866 14810 16192 26396 14360 16191 216148 114713 14186 19418 22123 20662 19052 14170 19053 19262 73699 640524 21402 16913 16165 75590 19175 209590 19177 51792 12978 19713 20586 19170 12985 22330 69677 99571 54448 13874 103554 16912 54401 83961 16188 19173 19172 21770 107971 26932 100986 226849 18611 23980 20418 26931 320484 225849 384783 12675 245684 19697 67112 18033 110157 19167 26441 16151 19419 18034 11472 16150 19171 545987 13649 70727 18595 26442 26440 19229 101809 18591 116849 16198 19152 76527 16160 237310 16197 19247 16161 12931 16175 17082 16199 26406 13019 93672 20908 16155 16156 16181 171095 237313 257630 16196 16172 338374 234836 57890 16880 140806 246779 93871 16171 15234 50905 215274 12804 50498 12803 16177 213208 16163 16162 230828 16174 329244 18413 16182 50931 107527 109658 58181 16068 12986 56708 18414 54473 83430 218624 16178 16173 15077 14255 14256 16168 16878 215257 319149 242700 16159 100042555 16170 16169 12367 12929 12362 18412 12928 22612 18747 15162 107746 22324 ROS, RNS PRODUCTION IN RESPONSE TO BACTERIA%REACTOME%R-HSA-1222556.4 ROS, RNS production in response to bacteria 66290 108664 13057 21871 27060 73834 140494 13058 17970 17972 12796 100039636 17969 18125 11974 18173 242341 18126 17002 114143 11966 11975 68775 11972 66237 11973 18127 11964 110935 66144 338375 66335 76252 74915 DISEASES OF CARBOHYDRATE METABOLISM%REACTOME DATABASE ID RELEASE 57%5663084 Diseases of carbohydrate metabolism 27357 22190 53412 232493 667035 14936 13853 GAP JUNCTION ASSEMBLY%REACTOME DATABASE ID RELEASE 57%190861 Gap junction assembly 14612 14615 353155 14620 14617 14622 14616 14618 14610 14619 14613 14611 14609 118454 225152 14623 14621 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME DATABASE ID RELEASE 57%176814 Activation of APC C and APC C:Cdc20 mediated degradation of mitotic proteins 66156 52206 668450 18817 12237 19186 22194 19188 56150 75430 216080 57296 67151 66413 19185 66998 53380 52717 19192 26445 17463 19166 69077 26444 26446 26443 52563 99152 18005 12534 69957 68999 68612 17222 22123 59029 19184 19179 22190 12236 20422 667035 19182 12427 19181 23997 66997 16913 228769 19175 70247 19177 67089 19170 21762 23996 103554 16912 19173 19172 59008 56317 73902 19167 26441 107995 19171 217232 26442 26440 30939 12428 PRESYNAPTIC FUNCTION OF KAINATE RECEPTORS%REACTOME DATABASE ID RELEASE 57%500657 Presynaptic function of Kainate receptors 14699 18796 66066 14700 18795 14701 14695 14704 14702 14710 64337 14706 14696 14688 14708 14807 18797 14693 14709 14697 SLC TRANSPORTER DISORDERS%REACTOME%R-HSA-5619102.1 SLC transporter disorders 12000 26361 103988 231103 54140 11657 11998 CELL-CELL JUNCTION ORGANIZATION%REACTOME%R-HSA-421270.1 Cell-cell junction organization 18759 56513 16480 12557 12737 12554 11727 56173 12738 71908 12388 12560 239857 12565 114141 54420 12552 12740 53624 320873 12555 241201 12558 12561 12550 56217 56863 12385 94332 58235 12741 93742 239096 75677 56492 58998 12739 12564 71740 58187 242653 93737 12695 239931 19294 12562 18417 12563 58220 224912 54419 60363 54725 16456 621628 64945 215654 GLYCEROPHOSPHOLIPID CATABOLISM%REACTOME DATABASE ID RELEASE 57%6814848 Glycerophospholipid catabolism 320981 68616 241274 56209 66569 50767 233552 SUMOYLATION OF CHROMATIN ORGANIZATION PROTEINS%REACTOME DATABASE ID RELEASE 57%4551638 SUMOylation of chromatin organization proteins 22196 56469 100043429 214669 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY%REACTOME DATABASE ID RELEASE 57%2564830 Cytosolic iron-sulfur cluster assembly 68523 67563 109006 26426 72199 26425 78797 13871 18971 26371 237911 269400 SUMOYLATION OF DNA DAMAGE RESPONSE AND REPAIR PROTEINS%REACTOME DATABASE ID RELEASE 57%3108214 SUMOylation of DNA damage response and repair proteins 13619 218210 66679 18226 69912 241915 56233 54383 227720 54563 223921 103468 70699 67711 72787 15204 240087 12189 269113 231042 67241 234865 69736 26370 20610 19069 107939 70238 170762 12578 11545 19821 18854 13006 19357 22658 59015 227699 20842 18141 66647 59004 22427 445007 68275 108989 19386 12144 69482 71805 68501 12418 30951 100043429 226026 22591 24061 22196 19365 20843 19763 12416 67872 56469 12151 108138 66341 TANDEM OF PORE DOMAIN IN A WEAK INWARDLY RECTIFYING K+ CHANNELS (TWIK)%REACTOME%R-HSA-1299308.1 Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK) 52150 16530 16525 PHOSPHOLIPASE C-MEDIATED CASCADE: FGFR1%REACTOME%R-HSA-5654219.1 Phospholipase C-mediated cascade: FGFR1 18750 18573 19088 18753 224129 18754 11513 11512 11515 11514 18752 104110 229709 18803 64654 14173 14164 12326 80857 16440 14180 110355 18747 14175 18574 14177 16438 18749 14165 210044 18575 432530 104111 12912 640703 67112 19087 19085 19084 14174 16439 SYNTHESIS OF PA%REACTOME%R-HSA-1483166.3 Synthesis of PA 67512 26971 55979 18784 78390 14732 231510 18805 14555 18806 333433 114874 210992 18779 18782 66350 215456 28169 18778 99010 26970 26565 18783 225010 102247 14712 68262 52123 PTK6 ACTIVATES STAT3%REACTOME DATABASE ID RELEASE 57%8849474 PTK6 Activates STAT3 20459 20848 106766 12702 VLDL INTERACTIONS%REACTOME DATABASE ID RELEASE 57%8855121 VLDL interactions 13131 171504 58194 22259 218203 18453 12757 11772 11425 232910 11773 19699 22260 11771 71770 67300 17777 11812 14360 22359 100102 238055 DEGRADATION OF THE EXTRACELLULAR MATRIX%REACTOME%R-HSA-1474228.3 Degradation of the extracellular matrix 72902 140709 19164 12816 18550 16621 12839 30800 50817 237759 77018 12822 73647 11502 12817 18073 12153 59287 17229 21858 381122 271127 23993 17381 17386 208936 170725 21857 58223 17228 23948 17389 13038 13035 17387 71753 72947 22072 12821 232345 12505 12819 107581 11501 23830 13033 69543 13040 17388 12380 66473 240913 50701 12337 30806 12338 12336 268958 23794 11490 11487 11491 11504 13179 56213 12818 21892 12367 24087 12335 12333 17385 12032 12334 20750 17390 13039 83995 12339 17392 16777 12823 240047 17384 17391 17393 17394 13030 17395 12550 12840 15530 16774 12841 12215 226519 16782 16780 18815 16776 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D%REACTOME DATABASE ID RELEASE 57%75815 Ubiquitin-dependent degradation of Cyclin D 59029 19184 19179 22190 20422 19186 19188 667035 19182 19181 57296 23997 67151 66997 66413 19185 66998 12567 53380 16913 12443 228769 19192 70247 19175 19177 67089 26445 17463 19166 19170 69077 21762 23996 103554 16912 26444 26446 19173 26443 19172 73902 19167 26441 19171 26442 26440 22123 SIGNALING BY MST1%REACTOME%R-HSA-8852405.1 Signaling by MST1 19882 15451 20733 15235 20732 SYNTHESIS OF IPS IN THE ER LUMEN%REACTOME DATABASE ID RELEASE 57%1855231 Synthesis of IPs in the ER lumen 17330 ORGANIC CATION ANION ZWITTERION TRANSPORT%REACTOME DATABASE ID RELEASE 57%549132 Organic cation anion zwitterion transport 19879 20517 18399 70840 20521 18400 108114 20519 30805 20518 20520 242126 SIGNALING BY LEPTIN%REACTOME DATABASE ID RELEASE 57%2586552 Signaling by Leptin 56438 16846 26395 67603 319520 235584 26403 16416 12223 54519 100042150 21894 11600 19060 19186 19188 327826 17169 194231 109905 14161 226525 57296 67151 215449 19185 66998 53380 14172 17967 15461 17463 83409 69077 29875 26417 26413 12323 108058 12322 18015 59029 19197 19417 19184 19179 22190 20422 171463 14573 667035 19182 16590 240057 19181 231474 64654 80903 14173 23997 14164 66997 18039 218397 110135 14585 20848 14178 80857 228769 14180 70247 67089 14586 14587 14175 21762 14177 23996 20416 11876 20851 14165 26554 18596 20850 109880 16399 54153 15200 640703 18673 12325 16706 69601 83379 22371 73902 233046 114716 12981 19415 63953 14174 12982 19252 16653 12984 240672 13537 12988 67836 16186 13385 14588 211323 16184 11836 18188 20740 20739 13645 16185 16452 216869 109689 18176 72399 70686 114715 240168 14268 66413 211255 18183 14083 16451 19192 16453 26445 12702 19166 18218 14812 76089 26444 26446 14811 26443 14813 19414 80297 14814 16183 20742 20741 21687 20743 16367 13866 14810 16192 26396 14360 16191 216148 114713 14186 19418 22123 20662 19052 14170 19053 19262 73699 640524 16913 75590 19175 19177 51792 19713 19170 22330 99571 13874 103554 16912 54401 83961 16188 19173 19172 21770 26932 107971 226849 100986 18611 23980 20418 26931 320484 225849 384783 245684 67112 110157 19167 26441 19419 11472 19171 545987 13649 70727 18595 26442 26440 101809 18591 19247 SIGNAL AMPLIFICATION%REACTOME%R-HSA-392518.1 Signal amplification 14706 14678 14696 14677 14679 70839 14688 14708 14693 14709 18441 14697 14699 14682 66066 14675 14700 21390 26416 14701 14676 14672 14674 18783 14695 14704 14702 14710 64337 242851 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME%R-HSA-975871.1 MyD88 cascade initiated on plasma membrane 19094 11596 110651 20210 12234 17164 72349 26965 20111 12912 26400 26417 240518 26413 23939 20112 257632 53791 266632 26420 107607 11909 16476 17260 13712 434174 22190 26414 108960 26395 26409 26401 667035 26398 26397 192656 17874 67603 19052 100040260 19053 319520 73699 26419 68652 11820 21402 66724 102626 22034 20203 66513 17258 93765 51792 26940 103583 26416 21770 12675 19697 18033 26399 18036 18035 231130 16151 18034 73086 16150 67245 93834 13211 66589 14281 26410 235584 16179 ACTIVATED POINT MUTANTS OF FGFR2%REACTOME DATABASE ID RELEASE 57%2033519 Activated point mutants of FGFR2 14165 14183 64654 67112 14173 80903 14164 14174 14178 80857 14172 14180 14175 14177 P75NTR SIGNALS VIA NF-KB%REACTOME%R-HSA-193639.1 p75NTR signals via NF-kB 18053 22190 667035 192656 17874 19697 18033 18049 18412 18035 16150 18759 22034 16179 ENOS ACTIVATION AND REGULATION%REACTOME%R-HSA-203765.1 eNOS activation and regulation 73178 320415 51793 640703 114886 18127 20751 13361 66394 68268 13430 69219 18777 15519 19286 12389 14528 11651 329416 19092 IL-6-TYPE CYTOKINE RECEPTOR LIGAND INTERACTIONS%REACTOME DATABASE ID RELEASE 57%6788467 IL-6-type cytokine receptor ligand interactions 16195 16162 18413 12931 54721 50931 16452 13019 56708 18414 16156 16880 16878 16451 246779 16159 100042555 12804 50498 12803 OLIGOMERIZATION OF CONNEXINS INTO CONNEXONS%REACTOME%R-HSA-190704.1 Oligomerization of connexins into connexons 14609 14618 14619 PHOSPHOLIPASE C-MEDIATED CASCADE; FGFR2%REACTOME DATABASE ID RELEASE 57%5654221 Phospholipase C-mediated cascade; FGFR2 18750 18573 19088 18753 224129 18754 11513 11512 11515 11514 18752 104110 229709 18803 64654 80903 14173 14164 12326 14178 80857 16440 14172 14180 110355 18747 14175 18574 14177 16438 18749 14165 210044 18575 432530 104111 12912 640703 67112 19087 19085 19084 14174 16439 SMALL INTERFERING RNA (SIRNA) BIOGENESIS%REACTOME%R-HSA-426486.2 Small interfering RNA (siRNA) biogenesis 76850 192119 23992 21357 236511 22099 239528 53424 214150 BBSOME-MEDIATED CARGO-TARGETING TO CILIUM%REACTOME DATABASE ID RELEASE 57%5620922 BBSome-mediated cargo-targeting to cilium 12469 12465 21454 12462 12461 12464 71492 52028 72569 76260 93730 216363 20607 319757 71769 207911 319845 67378 56297 102774 59030 241950 SIGNAL TRANSDUCTION BY L1%REACTOME%R-HSA-445144.1 Signal transduction by L1 104099 16416 18186 16402 19353 16728 16399 13001 26395 26417 22325 26413 13000 100039026 13649 26396 18479 17967 16412 16410 REGULATION OF MITOTIC CELL CYCLE%REACTOME DATABASE ID RELEASE 57%453276 Regulation of mitotic cell cycle 66156 52206 668450 18817 12237 22194 19186 19188 56150 75430 216080 57296 67151 66413 19185 66998 53380 52717 19192 20878 26445 17463 19166 69077 26444 12234 26446 26443 26965 52563 99152 18005 229776 20877 12534 12566 27401 69957 68999 68612 17222 22123 59029 19184 19179 22190 12236 20422 667035 56371 19182 12427 19181 23997 66997 21402 16913 228769 19175 70247 19177 67089 19170 21762 23996 103554 16912 19173 19172 67141 59008 56317 73902 19167 26441 107995 19171 217232 26442 26440 30939 12428 INTERCONVERSION OF POLYAMINES%REACTOME DATABASE ID RELEASE 57%351200 Interconversion of polyamines 212503 20229 OXIDATIVE STRESS INDUCED SENESCENCE%REACTOME DATABASE ID RELEASE 57%2559580 Oxidative Stress Induced Senescence 13619 14056 76850 216850 241915 13626 236511 26921 54383 26408 319181 665113 50932 494448 232440 15977 19094 382522 319176 12579 12578 19821 17164 22059 12571 13557 26400 26417 26413 13555 21781 624153 625328 51788 17165 15077 242705 319149 245688 26420 22166 52615 12418 15267 16476 319183 19646 26414 22190 319182 319178 26398 667035 319186 26397 319190 30951 213988 26419 100043858 102626 12580 12567 319168 319167 26416 217351 233833 19763 12416 17246 214150 26399 12151 319188 14281 15270 319169 78303 17454 SMAC-MEDIATED APOPTOTIC RESPONSE%REACTOME DATABASE ID RELEASE 57%111469 SMAC-mediated apoptotic response 12369 12367 11798 12371 66593 TANDEM PORE DOMAIN HALOTHANE-INHIBITED K+ CHANNEL (THIK)%REACTOME%R-HSA-1299287.1 Tandem pore domain halothane-inhibited K+ channel (THIK) 217826 FGFRL1 MODULATION OF FGFR1 SIGNALING%REACTOME%R-HSA-5658623.2 FGFRL1 modulation of FGFR1 signaling 64654 67112 14173 14165 114715 114716 14174 14172 116701 14175 GSD 0 (MUSCLE)%REACTOME%R-HSA-3828062.1 GSD 0 (muscle) 27357 14936 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME%R-HSA-69613.1 p53-Independent G1 S DNA damage checkpoint 19186 19188 57296 67151 66413 19185 11920 66998 53380 19192 17463 26445 19166 69077 26444 26446 26443 22123 59029 19184 19179 22190 20422 667035 19182 19181 23997 66997 16913 228769 70247 19175 67089 19177 19170 21762 23996 103554 16912 19173 19172 73902 19167 50883 26441 12530 19171 12649 26442 26440 LEADING STRAND SYNTHESIS%REACTOME%R-HSA-69109.2 Leading Strand Synthesis 19687 69263 67967 19718 18969 19075 18972 18538 69745 18971 72151 106344 18968 19076 GOLGI ASSOCIATED VESICLE BIOGENESIS%REACTOME%R-HSA-432722.1 Golgi Associated Vesicle Biogenesis 72685 20661 69178 14319 252903 20404 66616 11840 108011 109689 20615 216705 20955 21987 117197 108012 11768 15481 22320 13430 67602 11767 16004 18457 11774 14325 232946 67489 11765 11764 80912 233489 22318 27059 108124 29816 19345 67804 18704 94245 22042 14533 320634 11769 11777 12874 105245 245638 231580 77929 MRNA DECAY BY 5' TO 3' EXORIBONUCLEASE%REACTOME%R-HSA-430039.1 mRNA decay by 5' to 3' exoribonuclease 225929 13209 75901 353190 67207 66094 24127 67678 66373 319618 234699 50783 78651 27756 70640 MITOCHONDRIAL TRANSCRIPTION INITIATION%REACTOME%R-HSA-163282.1 Mitochondrial transcription initiation 15278 21780 216151 RNA POLYMERASE I PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 57%73772 RNA Polymerase I Promoter Escape 66136 21341 21340 20017 17749 21374 70333 66420 667501 245841 66467 21429 75316 64424 20016 20018 20019 106298 21339 14884 66671 23894 12572 17420 13871 13872 209357 69833 14885 100043714 THE NLRP1 INFLAMMASOME%REACTOME DATABASE ID RELEASE 57%844455 The NLRP1 inflammasome 195046 12043 12048 DISEASES ASSOCIATED WITH SURFACTANT METABOLISM%REACTOME%R-HSA-5687613.1 Diseases associated with surfactant metabolism 22130 12982 12984 20390 20389 52713 20388 20387 MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 57%397014 Muscle contraction 18519 17883 12289 12295 17885 12297 12298 15257 52150 16530 16525 72258 16528 16526 12294 56808 54376 12300 26903 223604 20410 21916 12293 16515 11931 57442 110893 81905 21393 50876 19303 50875 16520 11474 12299 13400 17907 16527 50874 54377 65973 12391 230103 22063 16518 18160 22138 241769 18091 18159 18125 80334 21388 56461 11928 54378 57814 20541 53419 93689 232975 81904 98660 22330 70357 20191 20192 100986 11932 11938 53313 11472 11937 17888 381290 320707 67972 14226 20190 11933 21894 217826 11475 229709 14167 57780 14168 59095 14166 20866 17898 22004 20928 109552 16529 20411 59310 332396 14169 109305 11749 16952 12306 17901 17906 230899 17897 109272 11941 216459 17868 14463 233199 59069 66240 54652 72821 21952 21955 21954 16514 210741 269717 211480 20266 13346 235281 16508 24046 434246 20265 16509 20269 21956 110880 109700 110891 67938 16511 56543 246133 76757 140723 17896 16506 319734 16535 67268 21924 21953 17996 21925 21957 15258 108017 74571 12323 108058 12322 56188 20264 399548 20271 20272 20273 20274 110876 16440 22352 18747 16438 12296 12288 640703 12325 12292 16419 17880 13405 97064 107589 17904 16439 VPR-MEDIATED NUCLEAR IMPORT OF PICS%REACTOME%R-HSA-180910.1 Vpr-mediated nuclear import of PICs 218210 66679 18226 69912 227720 54563 223921 103468 70699 72787 269113 231042 234865 69736 19069 107939 16646 170762 15361 59015 227699 18141 445007 108989 101739 19386 69482 71805 23825 SCAVENGING BY CLASS H RECEPTORS%REACTOME%R-HSA-3000497.1 Scavenging by Class H Receptors 20692 192188 238055 192187 AXIN MISSENSE MUTANTS DESTABILIZE THE DESTRUCTION COMPLEX%REACTOME DATABASE ID RELEASE 57%5467340 AXIN missense mutants destabilize the destruction complex 11789 56637 93687 72345 21770 26932 226849 12005 26931 225849 19052 19053 73699 51792 PINK PARKIN MEDIATED MITOPHAGY%REACTOME DATABASE ID RELEASE 57%5205685 Pink Parkin Mediated Mitophagy 22190 66410 66119 223696 667035 66734 170731 50873 100043869 67443 67414 18412 53333 28185 22333 66169 68943 67526 11793 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX%REACTOME%R-HSA-445989.2 TAK1 activates NFkB by phosphorylation and activation of IKKs complex 107607 434174 108960 26409 192656 17874 68652 66724 11820 22034 66513 20203 11596 20210 12675 19697 18033 18036 18035 16151 18034 16150 257632 13211 16179 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 57%450341 Activation of the AP-1 family of transcription factors 26420 26416 11909 26419 16476 19094 26414 14281 26417 26413 MYOCLONIC EPILEPSY OF LAFORA%REACTOME%R-HSA-3785653.1 Myoclonic epilepsy of Lafora 27357 22190 53412 232493 667035 14936 13853 FORMATION OF RNA POL II ELONGATION COMPLEX%REACTOME DATABASE ID RELEASE 57%112382 Formation of RNA Pol II elongation complex 67710 17749 66420 245841 66467 20021 20833 69241 20924 20922 14884 12572 17420 68092 69833 433702 68705 20022 69920 231329 98053 100043714 20020 107951 12454 114741 24116 214498 22083 54624 235497 66671 76246 66317 23894 57314 27632 13871 13872 58202 209357 14885 13716 67655 67923 27224 72949 12455 21399 DEFECTIVE PRO-SFTPB CAUSES PULMONARY SURFACTANT METABOLISM DYSFUNCTION 1 (SMDP1) AND RESPIRATORY DISTRESS SYNDROME (RDS)%REACTOME DATABASE ID RELEASE 57%5688031 Defective pro-SFTPB causes pulmonary surfactant metabolism dysfunction 1 (SMDP1) and respiratory distress syndrome (RDS) 22130 52713 20388 RHO GTPASES REGULATE CFTR TRAFFICKING%REACTOME%R-HSA-5627083.1 RHO GTPases regulate CFTR trafficking 94221 104215 12638 DIMERIZATION OF PROCASPASE-8%REACTOME%R-HSA-69416.1 Dimerization of procaspase-8 22030 14082 21933 14102 14103 22035 12370 71609 19766 SIGNALING BY TGF-BETA RECEPTOR COMPLEX%REACTOME%R-HSA-170834.1 Signaling by TGF-beta Receptor Complex 66313 18550 75788 17283 83814 21815 228839 12402 216080 18762 66105 12579 11545 211586 20482 433759 19650 19045 20481 19046 264064 21781 22192 67821 56207 19047 56513 65112 20901 107951 17131 56424 170749 20185 17872 12454 20602 14225 68010 11848 22190 93836 667035 70737 20683 13559 21803 104394 21813 21812 94093 17869 51813 102098 19042 22284 17127 17128 93742 17126 103573 18002 16477 97064 72949 16456 12455 18787 14479 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1%REACTOME DATABASE ID RELEASE 57%937041 IKK complex recruitment mediated by RIP1 106759 12475 142980 225471 56532 22190 667035 11797 100041766 19766 12675 216080 17087 16151 66105 11796 16150 22034 66589 93765 21898 DIGESTION OF DIETARY CARBOHYDRATE%REACTOME DATABASE ID RELEASE 57%189085 Digestion of dietary carbohydrate 58866 226413 11722 100043686 69983 232714 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN%REACTOME DATABASE ID RELEASE 57%170822 Regulation of Glucokinase by Glucokinase Regulatory Protein 218210 66679 18226 69912 227720 54563 223921 103468 70699 72787 103988 231103 269113 231042 234865 69736 19069 107939 170762 59015 227699 18141 445007 108989 19386 69482 71805 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE%REACTOME DATABASE ID RELEASE 57%69052 Switching of origins to a post-replicative state 19186 19188 57296 67151 66413 19185 66998 53380 18392 19192 26428 18393 26445 17463 26429 19166 69077 12576 26444 26446 26443 19645 12575 12566 22123 59029 19184 22190 19179 20422 667035 56371 19182 12427 19181 23997 66997 16913 228769 50793 19175 70247 19177 67089 19170 21762 23996 17215 17219 103554 17217 16912 56452 19173 66634 19172 67177 73902 19167 26441 23834 19171 17216 26442 26440 17220 12428 17218 FORMATION OF HIV ELONGATION COMPLEX IN THE ABSENCE OF HIV TAT%REACTOME DATABASE ID RELEASE 57%167152 Formation of HIV elongation complex in the absence of HIV Tat 107951 67710 17749 12454 66420 114741 245841 24116 66467 20021 69241 20833 20924 20922 14884 66671 23894 57314 27632 12572 17420 13871 13872 58202 68092 209357 69833 14885 68705 433702 13716 20022 69920 67655 231329 98053 67923 27224 100043714 72949 20020 12455 21399 CONJUGATION OF BENZOATE WITH GLYCINE%REACTOME DATABASE ID RELEASE 57%177135 Conjugation of benzoate with glycine 117147 107146 435528 REVERSIBLE HYDRATION OF CARBON DIOXIDE%REACTOME%R-HSA-1475029.1 Reversible hydration of carbon dioxide 12352 12349 76459 12354 230099 12351 71934 12353 56078 12346 23831 12350 ANTAGONISM OF ACTIVIN BY FOLLISTATIN%REACTOME%R-HSA-2473224.2 Antagonism of Activin by Follistatin 16324 83554 14313 16323 DEFECTIVE POMT1 CAUSES MDDGA1, MDDGB1 AND MDDGC1%REACTOME%R-HSA-5083633.1 Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1 13138 MISSPLICED GSK3BETA MUTANTS STABILIZE BETA-CATENIN%REACTOME DATABASE ID RELEASE 57%5339716 Misspliced GSK3beta mutants stabilize beta-catenin 11789 56637 93687 72345 21770 26932 226849 12005 26931 225849 19052 19053 73699 51792 TRANSLATION%REACTOME DATABASE ID RELEASE 57%72766 Translation 235606 66256 67437 20832 67768 76808 68028 100043755 66661 19899 67186 20115 217337 57294 667739 67025 27370 65019 67248 666669 100038991 100038875 100040021 56529 69019 66286 432502 66481 100040298 238217 56040 667618 66624 19989 76687 20818 13200 66235 55944 13669 27979 68135 107513 66085 26905 22384 53356 56347 13684 67204 223691 217869 13682 73830 16341 100042807 13681 54709 75705 98221 20014 67674 13685 13628 67398 13665 57743 66212 14852 225363 208643 14853 53421 100043039 18458 103963 67891 100042986 100042740 621100 100043295 67097 13629 100043000 625646 67281 633683 666899 667035 16785 100039316 267019 100040970 72265 19941 382492 24067 20055 66384 19951 20813 100042670 27058 68193 665189 55949 209354 668182 13667 19921 217715 20044 108067 668144 100043423 100043893 670832 100043876 629957 225058 22121 75617 667279 76846 27050 100043184 19934 66656 100040331 100043391 319195 68172 67160 241053 100043209 20102 67941 27207 668668 20103 672214 226982 622534 224045 20085 20084 GLYCOGEN SYNTHESIS%REACTOME%R-HSA-3322077.1 Glycogen synthesis 66681 72157 216558 27357 22190 53412 232493 74185 667035 14936 13853 105193 PHOSPHORYLATION OF EMI1%REACTOME DATABASE ID RELEASE 57%176417 Phosphorylation of Emi1 12534 107995 18817 67141 56371 ABC TRANSPORTER DISORDERS%REACTOME%R-HSA-5619084.3 ABC transporter disorders 67819 66753 19186 19188 269523 57296 67151 66413 19185 66998 53380 19192 20338 26445 20390 17463 19166 20389 12638 20388 69077 20387 193670 54197 26444 116891 26446 216440 26443 16514 22123 59029 19184 19179 22190 20422 667035 19182 19181 23997 66997 16913 228769 70247 19175 67089 19177 19170 21762 23996 103554 16912 19173 19172 244373 73902 19167 26441 19171 70377 20927 26442 226144 26440 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE%REACTOME DATABASE ID RELEASE 57%176407 Conversion from APC C:Cdc20 to APC C:Cdh1 in late anaphase 66156 52206 668450 22194 52563 56371 59008 99152 56317 75430 229776 216080 107995 69957 217232 52717 68999 68612 17222 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES%REACTOME%R-HSA-2022090.2 Assembly of collagen fibrils and other multimeric structures 12827 329941 12829 30800 94216 12822 18542 12830 94352 12835 12832 12833 16950 12831 12828 12837 12826 12153 67573 17386 12819 12842 12825 13040 21892 24087 13039 17392 12843 17393 13030 17395 18810 16774 12834 16403 245026 12836 373864 16782 12824 71355 16780 12476 12815 53867 12814 12813 16948 16949 192897 CENTROSOME MATURATION%REACTOME DATABASE ID RELEASE 57%380287 Centrosome maturation 19088 76816 18817 56455 76478 71909 219072 214552 237222 20873 18536 104318 22145 73738 26370 74470 219103 17997 99100 74360 68121 18472 27373 12009 13589 54130 76707 230376 22628 66296 236266 78887 18005 15519 381644 22154 225745 12534 214444 28135 231123 13427 13424 83922 208518 75786 18541 103733 101565 78177 69654 22153 225659 227613 16328 53598 22142 68475 22627 51792 18747 103768 51885 100986 75296 74237 259279 12537 101706 233276 MYD88 DEFICIENCY (TLR5)%REACTOME DATABASE ID RELEASE 57%5602680 MyD88 deficiency (TLR5) 266632 53791 17874 S33 MUTANTS OF BETA-CATENIN AREN'T PHOSPHORYLATED%REACTOME DATABASE ID RELEASE 57%5358747 S33 mutants of beta-catenin aren't phosphorylated 11789 56637 93687 72345 21770 26932 226849 12387 12005 26931 225849 19052 19053 73699 51792 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER%REACTOME%R-HSA-76066.1 RNA Polymerase III Transcription Initiation From Type 2 Promoter 17749 21374 66420 245841 20016 26939 70408 67486 12909 78929 20018 67065 67005 218832 69870 70428 74414 544971 233863 71752 72308 69833 70239 269252 67371 100043714 98488 BIOTIN TRANSPORT AND METABOLISM%REACTOME%R-HSA-196780.1 Biotin transport and metabolism 100705 110948 72621 110821 72039 66904 330064 26363 78038 107476 18563 GROWTH HORMONE RECEPTOR SIGNALING%REACTOME DATABASE ID RELEASE 57%982772 Growth hormone receptor signaling 15170 20851 17096 20850 11491 19109 26417 16452 26413 384783 16367 14600 20848 19116 12700 12703 216233 12702 19246 GAMMA-CARBOXYLATION OF PROTEIN PRECURSORS%REACTOME%R-HSA-159740.2 Gamma-carboxylation of protein precursors 14456 14068 14058 14071 14061 66901 56316 19128 19123 SYNTHESIS OF DNA%REACTOME%R-HSA-69239.1 Synthesis of DNA 18973 19687 69263 67967 19718 18972 18538 19891 69745 68240 18971 66413 19192 26445 19166 12576 26444 26446 26443 19645 12575 59001 72151 106344 66979 18974 68275 22123 56371 16913 19175 50793 19177 19170 103554 16912 19173 19172 19167 26441 19171 26442 26440 19186 19188 57296 67151 19185 66998 53380 18392 26428 18393 17463 26429 69077 327762 16881 14156 12544 12566 109145 272551 78833 69270 59029 18969 19075 19184 22190 19179 20422 667035 19182 12427 19181 23997 66997 228769 70247 67089 21762 23996 17215 17219 17217 56452 66634 67177 73902 23834 17216 18968 19076 17220 12428 17218 COPI-INDEPENDENT GOLGI-TO-ER RETROGRADE TRAFFIC%REACTOME DATABASE ID RELEASE 57%6811436 COPI-independent Golgi-to-ER retrograde traffic 69654 108148 14423 53598 213575 19330 226407 19346 56455 12121 18475 59288 28169 13191 68097 18472 18783 270192 67665 234663 22428 53357 13427 13424 76895 13426 110350 18476 AKT-MEDIATED INACTIVATION OF FOXO1A%REACTOME DATABASE ID RELEASE 57%211163 AKT-mediated inactivation of FOXO1A 56458 11652 23797 11651 INTERACTION WITH THE ZONA PELLUCIDA%REACTOME DATABASE ID RELEASE 57%1300644 Interaction With The Zona Pellucida 56622 22788 22787 71078 14595 22786 12659 11495 S45 MUTANTS OF BETA-CATENIN AREN'T PHOSPHORYLATED%REACTOME%R-HSA-5358751.1 S45 mutants of beta-catenin aren't phosphorylated 11789 56637 93687 72345 21770 26932 226849 12387 12005 26931 225849 19052 19053 73699 51792 RMTS METHYLATE HISTONE ARGININES%REACTOME%R-HSA-3214858.1 RMTs methylate histone arginines 15267 621893 16452 232440 20587 20588 140858 214572 83796 319163 66923 68094 12567 83797 319168 12443 319162 20586 83766 239985 99890 319167 77044 319176 319173 66993 66423 67155 57376 93760 59035 70465 624153 27374 15469 51788 56456 15077 13435 319149 15270 245688 319169 GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION%REACTOME%R-HSA-163841.2 Gamma carboxylation, hypusine formation and arylsulfatase activation 14456 18550 67902 13629 116905 67228 67728 63828 19128 19123 276770 208691 102115 11881 14061 57295 66901 99349 11883 238024 58911 66632 330817 74008 105638 77041 56316 14068 14058 14071 545260 271970 69740 REACTIONS SPECIFIC TO THE HYBRID N-GLYCAN SYNTHESIS PATHWAY%REACTOME DATABASE ID RELEASE 57%975574 Reactions specific to the hybrid N-glycan synthesis pathway 17309 INTRA-GOLGI TRAFFIC%REACTOME DATABASE ID RELEASE 57%6811438 Intra-Golgi traffic 73124 67542 56494 233824 242406 11840 109181 108123 17158 108124 226089 19159 97484 19158 19157 27277 17155 13047 76332 67474 18195 76877 53334 230815 11650 56389 72318 270160 102339 17156 54399 22365 228960 53611 19338 56418 338337 16834 75985 58244 17957 EPHA-MEDIATED GROWTH CONE COLLAPSE%REACTOME DATABASE ID RELEASE 57%3928663 EPHA-mediated growth cone collapse 19877 11848 19878 17886 16542 22612 14083 13636 13838 13839 17096 13836 13840 13841 13638 230126 13639 13637 71960 13842 15519 13835 67938 17880 14360 67268 13640 77579 13837 17904 53972 COLLAGEN FORMATION%REACTOME DATABASE ID RELEASE 57%1474290 Collagen formation 329941 12827 140709 12816 12829 30800 12839 237759 18453 77018 94216 12822 18542 12830 94352 12835 12832 12833 16950 12817 12831 12828 12837 67573 12153 12826 17386 213945 12821 18452 12819 269132 12842 107581 26433 69700 56401 12825 210530 13040 12406 26432 73368 330119 320452 56693 18451 216725 14789 19035 234407 76477 18822 12818 21892 24087 13039 17392 12823 12843 17393 13030 17395 18810 12840 16774 12834 16403 245026 237360 12836 12841 373864 16782 12824 71355 16780 12476 12815 53867 12814 12813 16948 16949 192897 INTERACTION WITH CUMULUS CELLS%REACTOME%R-HSA-2534343.1 Interaction With Cumulus Cells 74468 BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS%REACTOME%R-HSA-111453.1 BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members 12015 12122 12043 12125 12048 171543 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA%REACTOME%R-HSA-72203.1 Processing of Capped Intron-Containing Pre-mRNA 50996 77134 56194 15568 238831 67480 18521 22608 53379 13207 230596 67197 54723 56258 233908 53607 14105 66101 107701 59013 68479 70052 70767 15388 13204 68988 67797 67178 13684 51810 60321 81898 20227 11991 330361 232989 67439 66585 98758 57905 72198 319322 70233 83701 27366 76938 101943 94315 212880 15569 54633 19655 27967 76522 53317 66094 68592 66877 67678 11834 66070 192159 67958 13211 15382 50783 75062 72047 28035 78651 229279 66618 28000 68092 433702 56335 53319 15387 193116 107829 110809 225027 60365 331401 66511 68278 67337 228410 68219 19826 67996 73666 20382 53817 51786 71713 70579 66231 69823 233073 73826 69207 56488 108014 386612 17149 100040029 192160 625193 67332 20638 100043168 225160 20492 20641 66441 54196 54451 384091 64340 107686 192170 66899 622469 51796 21681 18789 20383 666609 68134 269061 98985 218210 66679 18226 67710 69912 17749 66420 245841 227720 54563 223921 103468 70699 20021 69241 72787 66055 70616 20624 66373 23983 20637 20630 76167 269113 231042 67465 234865 56031 69736 94230 19069 67500 15381 107939 22668 68981 76936 22184 170762 75956 71702 74351 22380 66125 15481 68816 19205 20639 20462 67959 68598 20646 80744 59015 78372 227699 100040177 69833 67225 18141 209416 68705 69192 54188 20022 74326 108062 69920 66642 445007 68879 76479 231329 68183 98053 66810 108989 320632 19386 83486 100043714 27756 20020 69482 67285 71805 20222 210529 ACTIVATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME DATABASE ID RELEASE 57%2485179 Activation of the phototransduction cascade 18587 14699 225600 214111 18588 14688 14685 20215 12788 212541 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS%REACTOME DATABASE ID RELEASE 57%997272 Inhibition of voltage gated Ca2+ channels via Gbeta gamma subunits 14699 14700 16524 14701 16515 16522 16513 14695 16520 16517 14704 242425 14702 14710 16519 16518 16521 14706 16516 54393 14688 14708 14693 14709 INOSITOL TRANSPORTERS%REACTOME%R-HSA-429593.1 Inositol transporters 20537 64452 233836 239606 230612 246787 53881 RECEPTOR-LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR%REACTOME%R-HSA-156988.2 Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor 54485 11487 13388 16450 16449 11491 18131 22190 18129 667035 18128 18132 SURFACTANT METABOLISM%REACTOME%R-HSA-5683826.1 Surfactant metabolism 14465 30937 20531 22130 216197 70546 12945 11540 20505 11551 52713 224792 27410 11553 16541 11541 13036 12982 12984 20390 18442 20389 20388 20387 INSULIN PROCESSING%REACTOME DATABASE ID RELEASE 57%264876 Insulin processing 239436 16334 66500 22318 16573 107371 69048 210148 105504 20907 67475 11891 17918 93721 211446 16572 20336 12876 18549 16574 50527 53413 69940 102058 66482 18548 SIGNALING BY FGFR2 IN DISEASE%REACTOME%R-HSA-5655253.1 Signaling by FGFR2 in disease 67710 17749 66420 245841 327826 20021 69241 18803 18176 20662 64654 14173 80903 14164 14178 80857 14172 14180 15461 14175 14177 14165 14183 18708 18706 67112 68092 69833 68705 14388 433702 20022 69920 14174 231329 98053 16653 100043714 20020 GLI3 IS PROCESSED TO GLI3R BY THE PROTEASOME%REACTOME%R-HSA-5610785.1 GLI3 is processed to GLI3R by the proteasome 19186 19188 57296 67151 66413 19185 66998 53380 19192 17463 26445 19166 69077 26444 12234 26446 26965 26443 14634 56438 22123 59029 19184 19179 22190 20422 667035 19182 19181 23997 24069 66997 21402 16913 228769 70247 19175 67089 19177 19170 18747 21762 23996 103554 18749 16912 56637 93687 19173 19172 73902 19167 26441 19171 26442 26440 RHESUS GLYCOPROTEINS MEDIATE AMMONIUM TRANSPORT.%REACTOME DATABASE ID RELEASE 57%444411 Rhesus glycoproteins mediate ammonium transport. 58176 56315 19743 FRUCTOSE METABOLISM%REACTOME%R-HSA-5652084.3 Fructose metabolism 11668 230163 11677 225913 20322 235582 16548 IGF1R SIGNALING CASCADE%REACTOME DATABASE ID RELEASE 57%2428924 IGF1R signaling cascade 667739 56438 26395 67603 319520 13684 75705 19042 64930 12283 72149 13631 66096 13685 54170 245670 68576 20869 68441 66508 227154 52187 69008 235584 105787 26403 16416 12223 54519 100042150 21894 11600 19060 19186 19188 327826 17169 194231 109905 14161 226525 57296 67151 215449 19185 66998 53380 14172 17967 15461 17463 83409 69077 29875 26417 26413 208643 12323 108058 12322 18015 59029 19197 19417 19184 19179 22190 20422 171463 14573 667035 19182 16590 240057 19181 231474 64654 80903 14173 14164 23997 66997 18039 218397 110135 14585 14178 80857 228769 14180 70247 67089 14586 14587 14175 21762 14177 23996 20416 11876 14165 26554 18596 109880 16399 18708 54153 15200 640703 18706 18673 12325 16706 69601 83379 22371 73902 233046 114716 12981 19415 63953 14174 12982 19252 16653 12984 240672 13537 12988 67836 16186 13385 14588 211323 16184 11836 18188 20740 20739 13645 16185 16452 216869 109689 18176 72399 70686 114715 240168 14268 66413 211255 18183 14083 16451 19192 16453 26445 19166 18218 14812 76089 26444 26446 14811 26443 14813 19414 80297 14814 74769 16183 20742 18709 20741 21687 20743 16367 13866 14810 16192 26396 14360 16191 216148 114713 14186 19418 22123 20662 19052 14170 19053 19262 73699 640524 16913 75590 19175 19177 51792 19713 19170 22330 99571 13874 108079 103554 241113 16912 54401 83961 16188 19173 19172 21770 107971 26932 100986 226849 18611 23980 20418 26931 320484 225849 384783 245684 67112 110157 19167 26441 19419 11472 19171 545987 13649 70727 18595 26442 26440 101809 18591 19247 75778 16000 16370 108099 16002 16001 19079 108097 19082 74370 81897 56717 22084 75669 225326 11652 11651 228775 18576 67605 56716 18607 14388 METABOLISM OF LIPIDS AND LIPOPROTEINS%REACTOME DATABASE ID RELEASE 57%556833 Metabolism of lipids and lipoproteins 26971 18784 110821 14792 78390 66904 218121 14245 18779 225845 20598 18782 66350 329502 18778 271844 99010 26970 26565 19046 12491 12647 54486 23887 14598 67512 55979 99035 56348 14732 217166 19063 18045 12686 66775 104112 106529 231510 433256 54397 170439 329910 14081 14555 94180 30963 333433 78245 18710 14104 210992 13167 14149 20249 13070 74559 170460 215456 243078 74205 56360 74156 50790 14626 68801 54326 66834 171210 171281 69923 17164 264895 83603 67800 14933 216739 15487 257633 171282 13350 225010 57874 102247 66198 545260 72482 233549 107476 18046 68262 70025 68393 70757 328845 52123 57357 54325 18044 64898 100042622 20845 68165 170459 11677 14148 64899 109791 58194 243168 68453 56406 18550 23945 16204 103161 18453 11772 11425 14080 18553 21884 67717 19699 320024 11771 93835 71770 65969 20493 11806 28250 11808 28253 70166 20494 11770 241274 240633 56209 76408 14079 66569 11303 50767 67469 100102 14776 16331 238055 233552 11807 13131 12140 239759 16332 18552 18946 228859 69060 19045 218203 17979 12757 232910 16890 74769 15450 11773 110611 18707 75497 18709 232345 16592 208677 103968 14077 16956 11814 68680 18947 14360 19047 22359 624219 57875 30924 16835 11816 171504 56453 22259 27801 76483 22260 12389 67470 67300 17777 27409 270669 66397 100017 12613 69573 12683 11307 105847 16816 56636 16891 320981 68616 19384 66905 110959 74114 12908 80911 74121 75778 16211 11370 106648 100040843 72054 100043508 13120 320997 631304 13118 21391 208285 13078 170749 75669 117150 225326 18717 228775 107141 13076 15183 18747 71519 72303 18749 56305 18720 24001 18719 108083 50493 11657 19211 18718 11842 15926 109151 11840 80509 13077 77371 11881 11883 18807 53357 15492 15212 15497 12640 13072 15211 16866 13079 11690 13358 625249 17001 11689 15107 67902 93747 11364 75613 11655 94112 21372 14219 59024 327987 19025 26457 19016 19013 14311 11812 19015 28169 66113 19014 11813 75320 28042 12651 102278 13026 18618 18783 19210 212862 68975 66586 70625 71760 234959 12660 66853 99712 66857 70208 270084 264064 236899 116939 105501 237928 232889 171285 67452 668257 320951 14712 56771 99683 231086 66826 18010 97212 106861 23956 665270 218865 17772 104709 97287 20185 20602 12891 77582 226856 52858 66727 266692 110911 27281 19062 30955 27388 70568 84095 20975 68671 114874 269180 245532 18705 192156 74451 104015 74596 18704 74182 74302 50877 110695 219135 66461 240752 192166 67073 67216 320207 53332 69792 237625 74129 234515 12116 320634 20466 18708 18706 59035 97064 100705 64292 12895 20773 12896 545975 57279 56632 78925 79554 12894 109136 11684 20775 96979 94224 67460 20933 245533 330450 54384 56690 110460 13110 67528 67219 21677 20524 113868 15360 100040592 111175 229003 110446 19225 19224 13075 11409 17764 70750 272636 23989 433323 69790 103236 12850 20597 74008 170826 17250 58994 54447 98386 110115 13074 18181 11363 104725 76199 16993 78894 71985 56185 28077 14421 14420 74442 12038 76267 227102 66612 66999 19731 13121 73724 12091 77626 208449 394434 12914 328572 12012 26459 83702 13123 11423 110196 14137 13479 69608 66469 19012 50784 18631 22239 20683 67420 76303 67916 230379 381379 58911 108079 224020 12408 64436 14667 103199 14466 234129 14073 66993 107650 30960 234729 12753 83493 12642 18711 72999 242259 14593 68682 16987 77041 73690 17436 70129 22601 15356 338521 216154 195733 13850 20788 70059 319554 56473 100434 231070 213603 11605 20859 228677 14200 271970 13177 81535 66844 67131 108098 13595 20280 20334 19156 18194 77116 74147 242083 94185 18670 218811 56491 15446 69772 66183 223753 11687 71365 14187 26379 19017 68603 108099 52635 14571 20698 13116 108097 76893 11520 67279 234309 66190 11606 238011 11886 19223 13122 19883 17978 17117 104086 20186 170789 77337 26458 105349 101502 208665 20181 15488 13124 27413 93732 17977 114664 13360 15483 15486 93898 11666 74754 11865 15485 66172 107765 22234 81004 171168 15484 20397 104759 67260 18805 21678 208982 21679 101490 18806 71854 67041 319446 217707 21676 268656 18143 52064 26896 228061 17855 66065 56356 26378 51813 18976 68865 14979 17850 67224 230027 71949 73166 78334 56794 71883 74159 23943 241447 13244 19215 14373 56075 16922 11688 11686 230101 75772 18760 235623 15490 14775 67103 67381 235293 66234 102632 56050 192191 67689 71911 GABA SYNTHESIS%REACTOME%R-HSA-888568.1 GABA synthesis 14417 14415 RRNA PROCESSING%REACTOME%R-HSA-72312.2 rRNA processing 52705 269470 98956 66249 53414 102462 68327 104318 230082 57315 76808 68028 100043755 216987 19899 67186 78394 20115 27373 57294 667739 67025 27370 66254 65019 100608 55989 67248 224823 666669 100038991 100038875 72181 100040021 67134 18572 21771 66878 432502 68147 66481 100040298 238217 56040 667618 67755 19989 217995 67619 213773 75273 215193 52530 245474 71340 69639 68533 66583 217038 65961 67390 72198 67053 227522 66181 67973 269536 54364 64934 67674 216156 69821 66138 233802 12181 102614 15108 104662 68626 52575 110109 27998 66132 76130 66362 80886 213895 229504 208144 227715 27966 50911 68017 14113 72544 100040177 66446 208366 109075 67676 59028 74035 67891 100042986 100042740 24128 621100 100043295 67097 353258 100043000 625646 75416 100041622 67281 622491 633683 50912 667035 666899 16785 100039316 105372 267019 70683 100040970 73674 223499 19941 382492 20055 14791 19951 57316 100042670 72554 68193 665189 668182 234374 19921 20044 668144 100043423 100043893 72515 670832 67045 100043876 629957 225058 27993 22121 75617 667279 76846 27050 100043184 19934 100040331 68979 100043391 319195 110816 68172 241053 224481 57750 100043209 67205 217109 20102 67941 27207 668668 20103 672214 622534 20085 20084 DEADENYLATION-DEPENDENT MRNA DECAY%REACTOME%R-HSA-429914.2 Deadenylation-dependent mRNA decay 69125 231464 353190 66373 27998 66362 18983 228140 227715 225929 50911 13209 103135 75901 58184 67207 72544 24127 66446 69305 208643 319618 192170 109075 104625 27756 70640 18458 218693 72587 72662 78893 74108 234594 69639 13684 66583 234699 13682 13681 75705 53621 232791 72068 68106 66094 67678 52846 50783 78651 AGMATINE BIOSYNTHESIS%REACTOME%R-HSA-351143.1 Agmatine biosynthesis 75986 242669 INTERLEUKIN RECEPTOR SHC SIGNALING%REACTOME DATABASE ID RELEASE 57%912526 Interleukin receptor SHC signaling 56438 26395 67603 319520 235584 26403 16416 12223 54519 100042150 21894 11600 19060 19186 19188 327826 17169 194231 109905 14161 226525 57296 67151 215449 18710 19185 66998 53380 14172 17967 15461 17463 83409 69077 29875 26417 26413 12323 108058 12322 18015 59029 19197 19417 19184 19179 22190 20422 171463 14573 667035 19182 16590 240057 19181 231474 64654 80903 14173 23997 14164 66997 18039 218397 110135 14585 14178 80857 228769 14180 70247 67089 14586 14587 14175 21762 14177 23996 20416 11876 14165 26554 18596 109880 14389 16399 18708 54153 15200 640703 18706 18673 12325 16706 69601 83379 22371 73902 233046 114716 12981 19415 63953 14174 12982 19252 16653 12984 240672 13537 12988 67836 16186 13385 14588 211323 16184 11836 18188 20740 20739 13645 16185 16452 216869 109689 18176 72399 70686 114715 240168 14268 66413 211255 18183 14083 16451 19192 16453 26445 19166 16331 18218 15170 14812 76089 16332 26444 26446 14811 26443 14813 19414 80297 14814 74769 16183 20742 18707 18709 20741 21687 20743 16367 13866 14810 16192 26396 14360 16191 216148 114713 14186 19418 22123 20662 19052 14170 19053 19262 73699 640524 16913 75590 19175 19177 51792 19713 19170 22330 99571 13874 103554 16912 54401 83961 16188 19173 19172 21770 107971 26932 100986 226849 18611 23980 20418 26931 320484 225849 384783 245684 67112 110157 19167 26441 19419 11472 19171 545987 13649 70727 18595 26442 26440 101809 18591 PLATELET CALCIUM HOMEOSTASIS%REACTOME%R-HSA-418360.1 Platelet calcium homeostasis 110893 26946 18436 20866 231602 94045 109552 228139 18440 22065 18438 109305 16440 20541 11941 16438 22068 269717 640703 11938 110891 53313 11937 381290 320707 67972 18439 16439 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS%REACTOME DATABASE ID RELEASE 57%446219 Synthesis of substrates in N-glycan biosythesis 12764 20452 241159 19025 67311 19703 235504 75540 50798 14584 331026 20448 69080 26938 109785 14583 227697 54128 29858 240119 107652 13481 74091 13480 234730 218138 18010 56174 54342 20447 12091 23956 20446 57357 67422 245847 110119 66248 66174 50935 24060 20454 192156 20451 50877 228368 22122 68563 225742 54613 20450 52014 57170 241230 20449 20442 20445 20443 69064 20440 20444 94181 TOXICITY OF BOTULINUM TOXIN TYPE A (BONT A)%REACTOME%R-HSA-5250968.1 Toxicity of botulinum toxin type A (BoNT A) 75209 64176 20614 64051 REGULATION OF GENE EXPRESSION IN EARLY PANCREATIC PRECURSOR CELLS%REACTOME%R-HSA-210747.1 Regulation of gene expression in early pancreatic precursor cells 14165 18609 18096 19213 15379 246086 21410 APC:CDC20 MEDIATED DEGRADATION OF CELL CYCLE PROTEINS PRIOR TO SATISFATION OF THE CELL CYCLE CHECKPOINT%REACTOME DATABASE ID RELEASE 57%179419 APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint 66156 52206 668450 12237 19186 22194 19188 56150 75430 216080 57296 67151 66413 19185 66998 53380 52717 19192 26445 17463 19166 69077 26444 26446 26443 52563 99152 18005 12534 69957 68999 68612 17222 22123 59029 19184 19179 22190 12236 20422 667035 19182 12427 19181 23997 66997 16913 228769 70247 19175 19177 67089 19170 21762 23996 103554 16912 19173 19172 59008 56317 73902 19167 26441 107995 19171 217232 26442 26440 12428 T(4;14) TRANSLOCATIONS OF FGFR3%REACTOME%R-HSA-2033515.1 t(4;14) translocations of FGFR3 14184 PRE-NOTCH EXPRESSION AND PROCESSING%REACTOME%R-HSA-1912422.1 Pre-NOTCH Expression and Processing 19719 18519 140484 16848 12914 17305 76850 16476 18550 328572 236511 239528 14595 333639 224143 19346 213988 14534 433586 12443 20338 103806 270118 217351 211586 54613 233833 22059 13557 13555 214150 21781 11938 19664 53313 11937 100042343 18131 20443 18129 18128 18132 17454 CD22 MEDIATED BCR REGULATION%REACTOME%R-HSA-5690714.1 CD22 mediated BCR regulation 15170 17096 15985 12518 12483 REGULATION OF TP53 ACTIVITY THROUGH ACETYLATION%REACTOME%R-HSA-6804758.1 Regulation of TP53 Activity through Acetylation 244349 19646 18854 328572 433759 23797 22059 107932 15182 26992 17192 78783 234366 70088 66262 216848 268936 11652 11651 245688 23942 229542 G-PROTEIN ACTIVATION%REACTOME%R-HSA-202040.1 G-protein activation 18610 18390 14706 14678 14696 14677 14679 14688 14708 14693 14709 18976 14697 14699 66066 14700 14701 14695 14704 14702 14710 64337 242851 14681 14685 14686 14687 HIV ELONGATION ARREST AND RECOVERY%REACTOME DATABASE ID RELEASE 57%167287 HIV elongation arrest and recovery 107951 67710 17749 66420 12454 245841 114741 24116 20021 20833 69241 20924 20922 57314 27632 58202 69833 13716 68705 20022 67655 69920 231329 98053 67923 27224 100043714 72949 20020 12455 21399 RAP1 SIGNALLING%REACTOME%R-HSA-392517.1 Rap1 signalling 18749 54401 380711 22631 110351 20469 109905 223864 110157 19419 215449 19395 56508 18747 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX%REACTOME%R-HSA-68827.1 CDT1 association with the CDC6:ORC:origin complex 19186 19188 57296 67151 66413 19185 66998 53380 18392 19192 26428 18393 26445 26429 17463 19166 69077 26444 26446 26443 22123 59029 19184 19179 22190 20422 57441 667035 19182 19181 23997 66997 16913 228769 50793 70247 19175 67089 19177 19170 21762 23996 103554 16912 56452 19173 66634 19172 67177 73902 19167 23834 26441 19171 26442 26440 PI-3K CASCADE:FGFR1%REACTOME%R-HSA-5654689.1 PI-3K cascade:FGFR1 211323 13645 18183 12576 12575 74769 18707 18709 16367 13866 14360 14186 19052 14170 19053 73699 51792 13874 56637 83961 21770 26932 226849 26931 225849 384783 12675 67112 13649 18595 18591 12223 16334 76850 100042150 236511 19247 16337 75778 15370 327826 12519 12524 18710 14172 12912 26417 26413 606496 244650 12015 56717 22084 77647 239528 12371 98432 16590 117150 64654 56458 14173 56484 80903 14164 213988 11652 18717 12478 11651 15937 14178 80857 14180 78757 228775 12487 14175 14177 217351 14165 18596 233833 23797 18708 15200 67605 18706 18720 17246 56716 16818 18719 214150 108083 83379 18607 14388 22324 14174 19211 227743 18718 109270 17454 58988 RHO GTPASE CYCLE%REACTOME%R-HSA-194840.1 Rho GTPase cycle 545156 192662 224014 269608 101497 13605 75547 26382 16800 57257 22325 232345 18709 19418 259302 232906 19353 11848 14270 236915 20662 117600 223666 54126 104215 330914 11854 69288 228543 73910 59040 106628 214952 80837 26934 214137 94190 73167 75404 50768 228482 216831 70719 71085 239027 170758 70497 69581 23912 78816 268970 236920 11855 69710 545481 19765 228359 56212 226652 11856 19354 12549 11852 71704 17925 213498 71709 320634 102098 16443 243362 277360 226970 214804 76117 207212 225358 20663 73341 232201 11853 56349 244867 58996 78514 74734 171207 16330 211896 24001 233071 14570 110279 270163 231532 223435 100038946 75415 109904 11857 218581 14569 22324 109934 246710 69632 14567 30938 212285 21844 17207 230972 213649 216445 53972 106952 14163 71302 UB-SPECIFIC PROCESSING PROTEASES%REACTOME DATABASE ID RELEASE 57%5689880 Ub-specific processing proteases 66313 22225 216869 109689 66413 170707 19192 74112 26445 19166 84585 11555 26444 26446 26443 22230 216185 11835 27401 77125 54198 50868 101565 22123 22030 74256 53376 17131 30941 15251 56505 22258 19766 22217 16913 19175 19177 21812 17869 19170 436004 224836 103554 16912 59025 17125 17127 17128 19173 217057 19172 17126 12005 14462 15239 71586 19167 18035 26441 16151 74996 19171 407786 83563 26442 26440 319169 69641 230073 22334 319651 621893 319181 19186 216825 19188 11797 235323 319189 57296 235441 67151 100756 56436 17248 11796 19185 22335 66998 53380 68031 17463 12638 382522 69077 101206 319176 14232 18970 319173 108645 22059 327799 24110 74493 59040 30940 100043869 246103 107986 74270 15925 107260 71472 269582 67561 22224 100683 84092 170822 72607 68350 15267 319183 59029 19184 22190 19179 319182 20422 26409 319178 667035 319186 319190 19182 12427 19181 23997 28185 19671 66997 14534 22333 319163 76800 22034 66513 319168 228769 319162 70247 66889 67089 56208 21762 319167 23996 71954 22284 21951 20439 12006 17246 54601 56324 73902 107995 12530 252870 319188 19211 236733 78303 12428 14479 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 57%2644602 Signaling by NOTCH1 PEST Domain Mutants in Cancer 18519 11487 56233 11491 333639 59287 54485 13388 16450 16449 433586 103806 79221 170787 225164 208727 15208 240055 433759 15205 26965 15213 15182 76580 15185 232232 70315 56198 15214 264064 15184 56438 12914 20185 328572 20602 22190 18011 667035 81004 14534 21402 21372 17869 15183 51813 270118 208117 19165 19664 100039623 100042305 18128 IRE1ALPHA ACTIVATES CHAPERONES%REACTOME%R-HSA-381070.1 IRE1alpha activates chaperones 14828 21894 381801 28106 56495 67398 140740 71853 11370 192193 105785 320209 14583 13191 12751 11972 57743 231997 66212 69162 71765 68090 72599 22642 28146 606496 100037258 11518 74322 16905 15191 69276 54616 53421 100043039 22393 27362 67838 52808 78943 20818 228998 56494 50907 12282 52639 66515 107513 74126 20416 225849 THE FATTY ACID CYCLING MODEL%REACTOME DATABASE ID RELEASE 57%167826 The fatty acid cycling model 74011 22227 20523 22228 22229 TRAF6 MEDIATED IRF7 ACTIVATION%REACTOME DATABASE ID RELEASE 57%933541 TRAF6 mediated IRF7 activation 22030 56480 12914 54123 21353 328572 56489 71956 16363 16362 72162 17874 228607 230398 71586 15977 217069 54131 66641 22034 230073 PLASMALOGEN BIOSYNTHESIS%REACTOME%R-HSA-75896.2 Plasmalogen biosynthesis 14712 228061 RNA POLYMERASE I PROMOTER OPENING%REACTOME DATABASE ID RELEASE 57%73728 RNA Polymerase I Promoter Opening 319176 15267 319183 319181 319182 319178 26417 319186 319190 21429 232440 624153 625328 51788 15077 319188 319168 319149 15270 17191 78303 319169 382522 319167 APOPTOSIS%REACTOME%R-HSA-109581.2 Apoptosis 11783 20740 18107 56455 66413 14083 19192 94275 26445 13169 19166 16646 14958 26444 26446 670717 80838 26443 50708 50709 13555 21781 11798 22123 224105 22030 434174 14082 97165 21933 13368 14102 13347 14103 12370 22035 66593 71609 19766 26419 16913 19175 22627 19177 19170 21898 106759 103554 16912 142980 11789 12122 54401 225471 19173 19172 19167 17087 26441 19171 26442 26440 22062 21981 18753 19186 100039786 19188 11797 16211 12028 57296 67151 19185 66998 53380 17463 209456 69077 22061 12475 55948 68097 22059 22631 22629 22628 74006 13176 13143 72993 12018 269582 11518 13144 107448 69635 19057 14939 107449 171543 12368 12369 19877 12015 12367 59029 227753 21873 14272 19184 13511 19179 22190 20422 667035 19182 27061 12371 223255 20230 19181 13510 12169 109620 23997 18772 66997 13512 14957 11652 56702 11651 18810 228769 16906 70247 14453 67089 21872 70415 56215 21762 22352 23996 12550 23797 18761 12043 12125 12048 78514 19058 73902 SHC-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%R-HSA-2428933.1 SHC-related events triggered by IGF1R 20662 16000 16002 16001 16653 15461 18176 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA%REACTOME DATABASE ID RELEASE 57%3134975 Regulation of innate immune responses to cytosolic DNA 56480 22040 446099 22190 20821 667035 72935 72512 207521 54131 69807 384309 58203 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING%REACTOME%R-HSA-389958.1 Cooperation of Prefoldin and TriC CCT in actin and tubulin folding 545486 22153 56612 238463 73710 227613 22143 67199 22151 11461 18637 22147 67951 22142 22327 22146 53857 109054 22152 22145 12466 12467 12469 12465 21454 12462 12461 12464 12468 14976 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES%REACTOME DATABASE ID RELEASE 57%450282 MAPK targets Nuclear events mediated by MAP kinases 26420 11909 16476 17260 13712 26414 67603 19052 100040260 19053 319520 73699 26419 19094 17258 51792 110651 26416 17164 21770 72349 20111 12912 26417 26413 23939 20112 73086 14281 235584 SLC-MEDIATED TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 57%425407 SLC-mediated transmembrane transport 231583 330064 214922 30791 70484 67547 106947 235504 72002 213053 106957 14977 227059 72027 236727 331004 77031 236794 105243 277973 226999 110895 71279 21366 58246 20538 24059 240332 50934 110877 30962 103098 240215 102680 170441 22598 23985 104245 269346 14664 20544 56643 56774 20498 330836 434203 20540 317750 20495 108652 20497 20496 229782 57738 54403 435818 20513 22348 27376 110893 20517 24060 20512 20511 63993 242607 74338 13162 73836 20541 67760 13521 214084 20510 20518 15275 15277 212032 83429 11815 77701 26569 26457 142681 225579 227659 77704 11998 110891 11989 239436 114304 230810 11416 66500 53945 65221 107723 76376 108115 215113 20528 53896 171429 59033 94229 69048 72401 22782 218756 22784 216225 210148 20515 246049 20504 238384 20535 94249 20532 338365 26570 70840 20516 20521 215335 18400 22232 108114 18174 20519 320718 30805 20499 20520 13487 242126 20536 20514 12870 15203 63959 216227 20500 19879 227394 80879 18399 353169 67473 20533 640703 57274 69354 237831 67582 20501 13340 114644 100561 20503 55963 55961 17254 75750 232156 12215 117591 243755 57138 101488 13723 209837 58807 98396 140919 243328 170756 11987 20529 76257 72045 114479 208890 20539 28250 28253 243616 14411 14412 232333 105727 242585 18173 56636 56017 242259 68682 27411 58176 70129 108052 56315 19743 100434 213603 218210 66679 18226 72621 69912 227720 54563 223921 103468 70699 72787 103988 109552 269113 231042 234865 69736 19069 107939 170762 20531 20505 59015 227699 214111 18141 233836 445007 239606 108989 19386 69482 71805 20537 14385 14377 64452 231103 20526 56485 228368 20525 68401 230612 246787 14378 53881 20527 11657 MISCELLANEOUS TRANSPORT AND BINDING EVENTS%REACTOME%R-HSA-5223345.1 Miscellaneous transport and binding events 80286 18716 67075 83429 214112 380836 74552 11518 233280 70701 12007 223473 236792 13829 93790 27360 11519 11732 TCR SIGNALING%REACTOME DATABASE ID RELEASE 57%202403 TCR signaling 108723 630146 16822 16428 66413 12042 19192 26445 19166 16331 216150 17973 26444 26446 26965 17444 26443 74769 18709 18481 14960 22323 14968 22637 19260 23880 14969 19264 16797 19271 224105 22123 192656 21402 16913 19175 93765 19177 103583 19170 103554 16912 19173 19172 12675 19697 18033 19167 18035 26441 16151 16150 19171 66589 26442 26440 12504 19186 19188 94212 100041766 216080 57296 67151 12500 19185 66998 53380 17463 69077 12234 59029 77647 19184 22190 19179 20422 26409 667035 19182 18803 19181 23997 66997 68652 12502 22034 12501 240354 18479 228769 70247 67089 21762 23996 22376 18708 18761 18706 14026 16818 73902 18607 19211 12988 ACYL CHAIN REMODELING OF DAG AND TAG%REACTOME DATABASE ID RELEASE 57%1482883 Acyl chain remodeling of DAG and TAG 116939 13350 23945 245532 668257 67800 66853 TRAFFICKING OF MYRISTOYLATED PROTEINS TO THE CILIUM%REACTOME DATABASE ID RELEASE 57%5624138 Trafficking of myristoylated proteins to the cilium 19889 74025 12879 56350 106840 RNF MUTANTS SHOW ENHANCED WNT SIGNALING AND PROLIFERATION%REACTOME%R-HSA-5340588.1 RNF mutants show enhanced WNT signaling and proliferation 14370 22416 14368 207742 14367 16973 14366 16974 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE%REACTOME DATABASE ID RELEASE 57%392154 Nitric oxide stimulates guanylate cyclase 242202 16438 18573 207728 23984 60596 234889 18127 54195 17540 58802 16531 18125 241489 18126 19092 54611 72413 18585 18576 435726 16533 18574 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 57%416993 Trafficking of GluR2-containing AMPA receptors 18750 53623 18195 243547 18752 18693 18751 11771 74053 14799 21912 14802 14800 TOXICITY OF BOTULINUM TOXIN TYPE C (BONT C)%REACTOME DATABASE ID RELEASE 57%5250971 Toxicity of botulinum toxin type C (BoNT C) 56216 20907 20614 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT%REACTOME DATABASE ID RELEASE 57%159231 Transport of Mature mRNA Derived from an Intronless Transcript 218210 66679 18226 69912 227720 54563 223921 103468 70699 72787 51786 13684 53319 269113 231042 234865 69736 94230 19069 107939 170762 59015 227699 68092 18141 54188 54451 433702 445007 66899 108989 19386 21681 69482 71805 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION%REACTOME DATABASE ID RELEASE 57%983231 Factors involved in megakaryocyte development and platelet production 16581 16554 209737 16565 16564 17133 16362 668303 16452 108829 57440 238130 74947 56697 230398 56248 252966 15353 259300 15977 18022 54131 20399 22761 63955 17863 208869 319899 12419 16580 16578 16923 14464 70218 16363 15182 11350 99982 330662 15129 19348 16561 12914 19353 328572 16571 13660 16568 217864 23921 16570 11640 16572 14461 14460 17134 73804 67299 68732 74764 12345 15135 76088 68813 15132 17135 14462 22762 110033 286942 75974 210293 229841 16593 16551 19088 16563 16573 22390 94176 217837 16569 12568 16562 71819 240641 232943 14465 14463 16552 433759 22059 170731 26934 625328 12566 15077 319149 78287 54123 16560 16579 269152 12343 67414 75050 73470 12340 18747 18749 20466 271457 114714 228421 19363 19087 19085 22365 19084 319991 16558 16594 TNFR1-MEDIATED CERAMIDE PRODUCTION%REACTOME%R-HSA-5626978.1 TNFR1-mediated ceramide production 18201 14694 58994 20598 21937 21926 VASOPRESSIN-LIKE RECEPTORS%REACTOME%R-HSA-388479.1 Vasopressin-like receptors 18429 12000 18430 26361 54140 11998 LIGAND-RECEPTOR INTERACTIONS%REACTOME DATABASE ID RELEASE 57%5632681 Ligand-receptor interactions 15245 117606 57810 19206 13363 20423 16147 14451 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 57%3304356 SMAD2 3 Phosphorylation Motif Mutants in Cancer 17127 17126 21803 21813 21812 PRE-NOTCH TRANSCRIPTION AND TRANSLATION%REACTOME%R-HSA-1912408.1 Pre-NOTCH Transcription and Translation 18519 12914 76850 16476 328572 236511 239528 333639 213988 14534 433586 12443 103806 217351 270118 211586 233833 22059 13557 13555 214150 21781 19664 18131 18129 18128 18132 17454 RRNA PROCESSING IN THE NUCLEUS AND CYTOSOL%REACTOME DATABASE ID RELEASE 57%8868773 rRNA processing in the nucleus and cytosol 52705 269470 98956 66249 53414 102462 68327 104318 230082 57315 76808 68028 216987 100043755 19899 78394 67186 20115 27373 57294 667739 67025 66254 27370 55989 65019 100608 224823 67248 666669 100038991 100038875 100040021 67134 18572 21771 66878 68147 432502 66481 100040298 238217 56040 67755 667618 19989 217995 67619 213773 75273 52530 215193 245474 71340 69639 66583 68533 65961 72198 67053 66181 227522 67973 269536 54364 64934 67674 216156 66138 233802 12181 102614 104662 110109 27998 76130 66362 80886 213895 229504 208144 227715 27966 50911 14113 72544 66446 100040177 208366 109075 67676 59028 74035 67891 100042986 100042740 24128 621100 100043295 67097 353258 100043000 625646 100041622 67281 75416 622491 633683 50912 666899 667035 16785 100039316 267019 105372 70683 100040970 73674 223499 19941 382492 14791 20055 57316 19951 72554 100042670 68193 665189 668182 234374 19921 20044 668144 100043423 72515 100043893 67045 670832 100043876 629957 27993 225058 22121 75617 667279 76846 27050 100043184 19934 100040331 68979 100043391 319195 110816 68172 241053 57750 100043209 67205 217109 20102 67941 27207 668668 20103 672214 622534 20085 20084 SHC-MEDIATED CASCADE:FGFR3%REACTOME%R-HSA-5654704.2 SHC-mediated cascade:FGFR3 20662 64654 80903 14173 14164 14172 80857 14180 16653 15461 14175 18176 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%R-HSA-2514859.2 Inactivation, recovery and regulation of the phototransduction cascade 18750 14272 107477 243923 18107 14688 14699 18108 18761 640703 18587 225600 245650 19674 18588 14919 56307 237178 14685 24013 110606 20215 75624 12788 212541 14913 73582 HYPUSINYLATION%REACTOME%R-HSA-204626.1 Hypusinylation 330817 208691 102115 276770 TRANSCRIPTION FROM MITOCHONDRIAL PROMOTERS%REACTOME%R-HSA-75944.1 Transcription from mitochondrial promoters 208595 15278 21780 216151 GPVI-MEDIATED ACTIVATION CASCADE%REACTOME DATABASE ID RELEASE 57%114604 GPVI-mediated activation cascade 16186 16184 16822 20963 19247 16185 16452 18762 18710 16451 16453 15170 17096 57257 22325 74769 16183 18707 18709 16192 14360 16191 16797 14726 104709 243816 56760 106722 19353 11848 234779 30955 11652 56212 11651 19354 11852 320207 20416 14127 14389 16188 18708 23797 18706 16818 18607 12981 22324 12982 12984 PTK6 PROMOTES HIF1A STABILIZATION%REACTOME DATABASE ID RELEASE 57%8857538 PTK6 promotes HIF1A stabilization 66725 93695 20459 15251 13649 15200 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL%REACTOME%R-HSA-198323.2 AKT phosphorylates targets in the cytosol 12576 12015 22084 56637 23797 67605 17246 12575 12371 12675 606496 11652 11651 GDP-FUCOSE BIOSYNTHESIS%REACTOME%R-HSA-6787639.1 GDP-fucose biosynthesis 234730 218138 69064 228368 75540 22122 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION)%REACTOME DATABASE ID RELEASE 57%2453902 The canonical retinoid cycle in rods (twilight vision) 19659 79235 22139 242864 15485 102294 241452 11304 19662 77974 19771 70061 19892 20897 17921 19682 19661 235033 27400 98711 216454 212541 17252 INTERACTIONS OF REV WITH HOST CELLULAR PROTEINS%REACTOME%R-HSA-177243.1 Interactions of Rev with host cellular proteins 218210 66679 18226 69912 227720 54563 19385 223921 103468 16211 70699 72787 100088 269113 231042 234865 69736 19069 107939 170762 103573 18148 59015 227699 18141 445007 108989 19386 19384 69482 71805 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT%REACTOME DATABASE ID RELEASE 57%72706 GTP hydrolysis and joining of the 60S ribosomal subunit 76808 68028 100043755 19899 67186 20115 57294 667739 67025 27370 65019 67248 666669 100038991 100038875 100040021 432502 66481 100040298 238217 56040 667618 19989 66235 55944 13669 27979 68135 66085 26905 22384 53356 56347 13684 67204 223691 217869 13682 73830 16341 100042807 13681 54709 75705 98221 13665 208643 67891 100042986 100042740 621100 100043295 67097 100043000 625646 67281 633683 667035 666899 16785 100039316 267019 100040970 19941 382492 20055 19951 100042670 68193 665189 668182 19921 20044 668144 100043423 100043893 670832 100043876 629957 225058 22121 75617 667279 76846 27050 100043184 19934 100040331 100043391 319195 68172 241053 100043209 20102 67941 27207 668668 20103 672214 226982 622534 20085 20084 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING%REACTOME DATABASE ID RELEASE 57%73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening 67710 68776 66464 21374 17749 66420 245841 235459 209361 66467 20021 69241 99730 319944 24074 108143 229906 83602 270627 14884 66671 228980 68153 74197 23894 12572 226182 216185 17420 13871 13872 209357 69833 14885 68705 72504 20022 69920 21343 231329 98053 407786 100043714 20020 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA%REACTOME%R-HSA-1834949.1 Cytosolic sensors of pathogen-associated DNA 17535 17749 66420 446099 245841 72512 207521 54131 11596 268857 20210 22040 214763 69833 384309 14375 100043714 58203 56480 12914 54123 328572 434174 22190 20821 667035 72162 19766 17874 20016 26939 70408 67486 12909 11820 78929 20018 20203 67065 67005 218832 69870 70428 20852 74414 106759 142980 56532 12387 12675 19697 72935 18033 18036 18035 16151 18034 16150 22596 13211 69807 19090 UCH PROTEINASES%REACTOME%R-HSA-5689603.1 UCH proteinases 235134 12021 621893 228790 19186 19188 75302 56249 108155 57296 67151 66413 56436 19185 66998 109275 53380 19192 26445 17463 19166 68142 110962 69077 319176 26444 319173 26446 26443 22632 17425 22223 50933 68837 56456 56207 70020 15161 22123 15267 17131 59029 19184 11461 19179 22190 69714 56505 20422 667035 19182 19181 227195 71599 23997 66997 233875 319163 21803 16913 319168 228769 70247 21813 19175 319162 67089 21812 19177 19170 319167 21762 23996 103554 16912 225280 19173 19172 104416 18002 73902 19167 26441 218214 19171 26442 319169 26440 14479 MITOTIC ANAPHASE%REACTOME DATABASE ID RELEASE 57%68882 Mitotic Anaphase 18817 22367 67629 26951 69928 105988 66413 19192 26445 19166 11799 236930 68014 71978 26444 18472 26446 208628 57294 26443 13589 52696 67849 76707 67733 83815 102920 76464 218914 66570 83431 108911 76499 18221 12617 19047 75786 26886 66934 224640 13726 22123 19052 19053 73699 16913 19175 19177 51792 19170 103554 16912 19173 73804 21770 19172 26932 226849 26931 103573 225849 19167 26441 19171 229841 26442 26440 23825 66156 69912 16563 52206 668450 12237 22194 19186 103468 19188 56150 75430 216080 57296 67151 19185 66998 53380 52717 17463 234865 69736 69077 52276 13006 52563 99152 19357 59015 20877 20842 16319 445007 69957 68999 19386 68612 17222 110379 320394 226747 66442 12615 59029 72155 108000 19184 12236 22190 19179 60411 20422 625534 667035 232987 19182 66468 19181 67052 52504 23997 66997 67139 71782 71521 16906 228769 70385 70247 71876 67089 73470 100710 21762 70454 23996 24061 17120 20843 59008 228421 56317 73902 244495 107995 381318 66336 217232 67037 216965 72415 56430 380664 30939 66977 12235 TP53 REGULATES TRANSCRIPTION OF CASPASE ACTIVATORS AND CASPASES%REACTOME DATABASE ID RELEASE 57%6803207 TP53 Regulates Transcription of Caspase Activators and Caspases 12368 11783 22062 12905 22059 12366 11920 12362 57913 268973 22061 ARMS-MEDIATED ACTIVATION%REACTOME%R-HSA-170984.1 ARMS-mediated activation 56438 26395 67603 319520 77480 235584 26403 16416 12223 54519 100042150 21894 11600 19060 19186 19188 327826 17169 194231 109905 14161 226525 57296 67151 215449 19185 66998 53380 14172 17967 15461 17463 83409 69077 29875 26417 26413 12323 108058 12322 18015 59029 19197 19417 19184 19179 22190 20422 171463 14573 667035 19182 16590 240057 19181 231474 64654 80903 14173 23997 14164 66997 18039 218397 110135 14585 14178 80857 228769 14180 70247 67089 14586 14587 14175 21762 14177 23996 20416 11876 14165 26554 18596 109880 16399 54153 15200 640703 18673 12325 16706 69601 83379 22371 73902 233046 114716 12981 19415 63953 14174 12982 19252 16653 12984 240672 13537 12988 67836 16186 13385 14588 211323 16184 11836 18188 20740 20739 13645 16185 16452 216869 109689 18176 18049 72399 70686 18211 114715 240168 14268 66413 211255 18183 14083 16451 19192 16453 26445 19166 18218 14812 76089 26444 26446 14811 26443 14813 19414 80297 14814 16183 20742 20741 21687 20743 16367 13866 14810 16192 26396 14360 16191 216148 114713 14186 19418 22123 20662 19052 14170 19053 19262 73699 640524 16913 75590 19175 19177 51792 19713 19170 22330 99571 13874 103554 16912 54401 83961 16188 19173 19172 21770 26932 107971 226849 100986 18611 23980 26931 20418 225849 320484 384783 245684 67112 110157 19167 26441 19419 11472 19171 545987 13649 70727 18595 26442 26440 101809 18591 12928 FREE FATTY ACIDS REGULATE INSULIN SECRETION%REACTOME DATABASE ID RELEASE 57%400451 Free fatty acids regulate insulin secretion 14682 18796 14675 18795 14676 14672 18797 233081 UNC93B1 DEFICIENCY - HSE%REACTOME DATABASE ID RELEASE 57%5602415 UNC93B1 deficiency - HSE 142980 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA%REACTOME DATABASE ID RELEASE 57%3359454 Defective TCN2 causes hereditary megaloblastic anemia 21452 POST NMDA RECEPTOR ACTIVATION EVENTS%REACTOME%R-HSA-438064.1 Post NMDA receptor activation events 12323 55984 13385 108058 12322 19417 11514 12326 18039 20130 15461 18747 14812 18749 110651 109880 432530 14811 20111 104111 14813 12912 640703 100986 14814 12325 26413 20112 110157 18607 67071 11472 14810 19418 DNA DAMAGE RECOGNITION IN GG-NER%REACTOME DATABASE ID RELEASE 57%5696394 DNA Damage Recognition in GG-NER 72584 235134 99375 108679 22190 11461 56505 69714 13194 667035 56249 227195 233875 26754 26893 109275 26891 22591 68142 26370 100043806 26894 225280 11545 22632 11546 19358 19359 12848 107986 56456 26572 56438 70020 26895 CELL CYCLE, MITOTIC%REACTOME DATABASE ID RELEASE 57%69278 Cell Cycle, Mitotic 18973 19687 69263 67967 19718 18972 76816 22367 18817 18538 67629 19891 74549 69745 14245 68240 69928 18971 105988 70099 77744 56455 76478 71909 219072 214552 237222 20873 18536 104318 22145 73738 20878 26370 74470 219103 52683 17997 236930 99100 68014 74360 71175 68121 66352 18472 208628 27373 382030 57294 12009 68298 13589 52696 54130 67849 76707 67733 230376 83815 66296 102920 236266 76464 78887 218914 18005 66570 19046 83431 59001 381644 13000 72151 22154 67181 106344 225745 100039026 214444 108911 28135 76499 66979 231123 18221 18974 13427 12617 13424 52432 68275 83922 215387 208518 70231 75786 76044 18541 26886 103733 66934 101565 224640 78177 13726 17274 69654 22153 225659 71648 16475 227613 17931 16328 53598 22142 68475 103583 19186 19188 57296 67151 19185 66998 53380 17463 69077 12234 433759 13006 26413 20842 320394 226747 78658 66442 12615 59029 72155 108000 14211 19184 13001 19179 60411 20422 625534 67956 232987 19182 66468 56205 59021 19181 67052 52504 64898 23997 217718 66997 671392 67139 67121 59125 71782 71521 228769 70385 70247 71876 67089 59126 100710 59046 21762 70454 23996 73902 64899 244495 381318 66336 244329 67037 216965 72415 56430 380664 30939 66977 12235 26951 66413 19192 26445 19166 26444 26446 26443 229776 19047 19348 22123 20459 16913 19175 19177 19170 103554 16912 73804 19173 19172 100986 103573 19167 26441 19171 229841 26442 26440 23825 18750 19088 232440 624153 625328 51788 15077 319149 18969 19075 16906 18747 67177 67141 20135 13361 18968 19076 15519 74498 19646 56371 71988 77805 13548 12447 50793 22627 103768 51885 75660 629959 74237 15366 231506 259279 12537 101706 56299 72568 21664 233276 70024 66156 52206 16563 668450 22390 319181 12237 22194 56150 75430 216080 27214 19324 21973 52717 71819 18392 26428 18393 26429 382522 327762 12448 22059 22628 52563 99152 19357 12544 12545 12534 12566 16319 69957 12442 68999 68612 17222 99412 76308 319183 22190 12236 319182 319178 667035 319186 319190 12427 268930 73470 17215 17219 17217 17120 29870 56452 66634 319152 75296 59008 56317 228421 23834 107995 12532 12530 217232 319188 17216 15270 78303 17220 12428 17218 57813 22171 12579 11799 12576 12578 17187 71978 211586 19651 19650 26965 12571 13557 12572 19645 12575 17420 13555 21781 27401 242705 328572 57441 19052 19053 73699 100043858 21402 12580 12567 13559 12443 104394 51792 12444 17869 66671 54124 12445 21770 26932 226849 26931 225849 319169 218210 66679 18226 69912 227720 54563 223921 103468 70699 14235 72787 18751 269113 231042 234865 69736 19069 107939 319176 170762 52276 16881 14156 56041 20877 59015 12531 227699 18141 445007 109145 272551 108989 78833 19386 69270 69482 110379 71805 15267 72119 15516 319168 319167 24061 20843 17865 ALPHA-DEFENSINS%REACTOME%R-HSA-1462054.1 Alpha-defensins 12504 11870 22072 CREATINE METABOLISM%REACTOME%R-HSA-71288.1 Creatine metabolism 240332 243616 12709 14411 76722 67092 102857 14431 12716 12715 CALCITONIN-LIKE LIGAND RECEPTORS%REACTOME%R-HSA-419812.1 Calcitonin-like ligand receptors 54598 51801 223780 11535 12311 12310 56089 15874 54409 TRAFFICKING OF DIETARY STEROLS%REACTOME DATABASE ID RELEASE 57%265473 Trafficking of dietary sterols 67470 27409 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS%REACTOME%R-HSA-425374.1 Amino acid and oligopeptide SLC transporters 20513 11989 22348 65221 27376 215113 53896 235504 72401 216225 20512 246049 20504 20511 242607 20532 26570 74338 14411 215335 67760 21366 20514 50934 103098 30962 102680 216227 22598 105727 56774 56643 69354 330836 20510 100561 55963 20540 17254 209837 57738 140919 11987 76257 114479 20539 RNA POLYMERASE III TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 57%76046 RNA Polymerase III Transcription Initiation 17749 21374 66420 245841 20841 20016 26939 70408 67486 12909 78929 20018 67065 67005 218832 69870 70428 74414 233863 227644 544971 75627 66596 102209 77634 71752 72308 330959 69833 66653 70239 269252 67371 100043714 98488 18986 HOST INTERACTIONS WITH INFLUENZA FACTORS%REACTOME DATABASE ID RELEASE 57%168253 Host Interactions with Influenza Factors 218210 66679 100039592 18226 69912 100038882 227720 11740 54563 223921 103468 16211 70699 16648 16649 72787 21803 269113 231042 234865 69736 19069 107939 16646 170762 59015 227699 54196 18141 54188 445007 19106 381686 108989 19386 69482 71805 DEFECTIVE TRP MAY CONFER SUSCEPTIBILITY TOWARDS THYROID PAPILLARY CARCINOMA (TPC)%REACTOME DATABASE ID RELEASE 57%5619107 Defective TRP may confer susceptibility towards thyroid papillary carcinoma (TPC) 103988 231103 APC TRUNCATION MUTANTS HAVE IMPAIRED AXIN BINDING%REACTOME DATABASE ID RELEASE 57%5467337 APC truncation mutants have impaired AXIN binding 11789 56637 93687 72345 21770 26932 226849 12005 26931 225849 19052 19053 73699 51792 ENDOSOMAL VACUOLAR PATHWAY%REACTOME%R-HSA-1236977.1 Endosomal Vacuolar pathway 14991 240028 13040 667803 12010 13039 15006 240095 15007 MITOCHONDRIAL TRNA AMINOACYLATION%REACTOME%R-HSA-379726.1 Mitochondrial tRNA aminoacylation 71941 353172 70120 71807 226539 69955 70791 74776 230577 244141 102436 224805 85305 71984 212679 97541 70560 67417 381314 68915 109093 OPSINS%REACTOME%R-HSA-419771.1 Opsins 14539 12057 13603 353344 30044 20132 57811 212541 DISEASE%REACTOME DATABASE ID RELEASE 57%1643685 Disease 110821 72039 66904 13363 66753 78038 20423 16147 11603 59287 12010 76808 68028 100043755 19899 67186 20115 57294 667739 67025 27370 65019 67248 666669 100038991 100038875 100040021 56438 432502 14375 66481 100040298 238217 53791 56040 667618 224105 19989 266632 22318 12527 26395 26398 17874 12491 12229 20614 21898 106759 142980 21899 17087 70377 24088 20927 226144 21897 12223 12504 100042150 19186 19188 327826 52713 57296 22416 67151 18710 19185 66998 53380 14149 14172 13070 15461 17463 69077 16974 12475 117149 12234 108154 433759 16514 12912 74493 26400 68092 433702 107476 12317 216725 11504 59029 100038882 19184 19179 20422 19182 16590 19181 80903 23997 66997 14178 228769 70247 67089 21762 23996 20416 14165 68165 18596 14148 15200 640703 16818 83379 73902 22596 14174 12982 16653 12984 194309 67897 66914 211323 24018 18550 68776 66464 83814 11772 235459 13645 107305 209361 66467 18571 20833 18176 99730 319944 18107 11771 24074 93835 108143 71770 229906 65969 66413 100088 83602 18183 270627 20924 20922 19192 75608 66201 26445 14884 19166 76959 228980 16646 26444 15361 26446 26443 12757 232910 74769 11773 18707 18709 16367 13866 26396 14360 14186 22123 12000 268373 12767 107951 330192 20479 21374 12454 114741 24116 319583 19385 68953 20662 14170 26361 67300 54140 74126 16913 19175 19177 19170 13874 52348 103554 66700 16912 12774 18108 83961 22088 68153 19173 74197 19172 23894 57314 27632 116733 226182 105513 103573 384783 13871 13872 67112 58202 209357 19167 208092 26441 14885 13716 72504 19171 67655 21343 13649 66371 67923 18595 27224 26442 101739 19384 26440 72949 12455 21399 18591 23825 75717 11487 100039592 64176 11491 19247 54219 108664 109129 11740 15370 238505 94176 67096 64051 210009 16211 17200 16648 12519 53627 433923 12524 13016 16649 12539 13017 14603 14539 12057 14184 14183 193740 606496 100037258 54188 19659 12015 56717 22084 77647 14225 20971 20969 19662 12371 18803 56458 56484 11652 231103 12478 11651 78757 12487 15183 15530 22139 208117 23797 67605 17246 56716 20970 19165 18148 231413 18607 100039623 75209 50493 14388 100042305 56216 22324 15529 11739 22317 11657 107975 19106 381686 227743 70572 12526 109270 58988 14370 18519 14734 14368 14367 207742 242864 15926 20357 252903 12402 11840 17829 100689 233744 54485 13388 16450 16449 433586 20907 14735 15007 15519 21416 17063 18636 30806 14366 23794 269328 19353 13853 19771 20897 21452 53412 21372 71951 18563 23888 20980 17127 19664 108138 27357 407786 232493 14936 14733 20979 100039649 103978 140474 269523 79221 170787 225164 208727 15208 108012 240055 73732 11768 15205 15213 76580 15185 11998 232232 70315 56198 15214 264064 11767 15184 121021 13004 12111 29873 11765 13179 11764 13003 20185 20602 12032 22190 240322 667035 64654 14173 224116 14164 67529 353328 20848 80857 14180 432508 20846 13047 14175 14177 21848 67384 20851 360013 21951 20850 14389 76007 18708 269959 18706 11769 75296 110279 14182 244373 100705 109136 13138 207596 20390 20389 20388 20387 12576 271127 208936 26965 15182 12572 216185 12575 17420 210417 54196 330119 240913 330267 12914 108153 328572 77739 18011 21826 21825 19052 19053 73699 21402 21803 21813 21812 51792 17869 66671 11789 56637 17128 93687 72345 17126 21770 26932 226849 12387 243369 12005 26931 77794 225849 12675 19697 18033 18036 18035 16151 18034 16150 234130 18131 84035 13380 73016 18129 16973 18128 56811 18132 67819 218210 66679 18226 67710 69912 17749 56233 66420 245841 227720 54563 22031 223921 333639 103468 70699 20021 69241 20356 72787 103988 224697 14264 18295 269113 231042 20338 103806 27047 234865 17002 116847 12638 69736 16545 19069 17022 107939 170762 193670 54197 16881 116891 14156 216440 239337 59015 227699 223838 69833 18141 68705 20022 69920 445007 231329 98053 229595 108989 66548 19386 100043714 20020 69482 71805 67891 100042986 100042740 140580 621100 100043295 67097 13629 22130 100043000 625646 67281 633683 666899 81004 16785 100039316 267019 100040970 15516 12330 14534 19941 382492 20055 19951 100042670 51813 18976 68193 665189 668182 17850 15162 19921 270118 20044 668144 100043423 100043893 235130 670832 100043876 629957 237360 225058 22121 75617 667279 279028 76846 27050 100043184 19934 100040331 100043391 319195 68172 56229 241053 100043209 20102 67941 27207 668668 226866 20103 672214 622534 20085 20084 ABC TRANSPORTERS IN LIPID HOMEOSTASIS%REACTOME%R-HSA-1369062.2 ABC transporters in lipid homeostasis 26874 27403 217265 19299 11305 11666 217262 19298 74591 27410 67470 11806 27409 11307 56535 76184 192663 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1%REACTOME DATABASE ID RELEASE 57%174113 SCF-beta-TrCP mediated degradation of Emi1 19186 19188 57296 67151 66413 19185 66998 53380 19192 17463 26445 19166 69077 26444 12234 26446 26965 26443 22123 59029 19184 19179 22190 20422 667035 19182 56371 19181 23997 66997 21402 16913 228769 70247 19175 67089 19177 19170 21762 23996 103554 16912 19173 19172 67141 73902 19167 26441 107995 19171 26442 26440 SYNTHESIS OF PI%REACTOME%R-HSA-1483226.2 Synthesis of PI 74596 52858 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 57%166058 MyD88:Mal cascade initiated on plasma membrane 19094 11596 110651 12475 20210 117149 12234 17164 72349 26965 20111 12912 26400 26417 240518 26413 23939 20112 257632 266632 26420 107607 11909 16476 17260 13712 434174 22190 26414 108960 26395 26409 26401 667035 26398 26397 192656 17874 12491 67603 19052 100040260 19053 319520 73699 12229 26419 68652 11820 21402 66724 102626 22034 20203 66513 17258 24058 93765 12703 51792 26940 103583 21898 73914 26416 21770 12675 19697 21899 18033 26399 18036 231130 18035 17087 16151 18034 73086 16150 67245 93834 13211 66589 14281 24088 26410 21897 235584 16179 FGFR3C LIGAND BINDING AND ACTIVATION%REACTOME%R-HSA-190372.2 FGFR3c ligand binding and activation 64654 80903 14173 14164 14425 14172 80857 14180 14175 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP)%REACTOME%R-HSA-2559582.2 Senescence-Associated Secretory Phenotype (SASP) 66156 52206 668450 319181 16175 22194 232440 75430 216080 52717 382522 12579 77683 319176 110651 12576 16193 12578 20111 12571 26417 52563 12575 26413 99152 23939 20112 624153 625328 12566 51788 15077 69957 12608 68999 319149 68612 29817 17222 15267 319183 110147 16476 22190 319182 319178 667035 319186 319190 56371 12427 100043858 12580 12567 20848 319168 319167 59008 56317 19697 18033 217232 319188 14281 15270 78303 319169 12428 HIV TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 57%167161 HIV Transcription Initiation 67710 68776 66464 21374 17749 66420 245841 235459 209361 66467 20021 69241 99730 319944 24074 108143 229906 83602 270627 14884 66671 228980 68153 74197 23894 12572 226182 216185 17420 13871 13872 209357 69833 14885 68705 72504 20022 69920 21343 231329 98053 407786 100043714 20020 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS%REACTOME DATABASE ID RELEASE 57%2173782 Binding and Uptake of Ligands by Scavenger Receptors 12827 71693 14319 15122 12282 140792 17167 12843 12826 12491 11806 15439 71145 93671 238055 11699 20210 15458 16971 380713 117158 20692 192188 16069 15519 12842 15505 12825 11657 14325 15129 12317 22027 20288 192187 11816 REGULATION OF KIT SIGNALING%REACTOME%R-HSA-1433559.1 Regulation of KIT signaling 18750 15170 23921 17096 16818 12402 16590 20662 22612 54607 14360 12703 16923 STIMULI-SENSING CHANNELS%REACTOME%R-HSA-2672351.2 Stimuli-sensing channels 243634 105355 217843 97086 17364 83814 212989 26946 68279 74446 56407 58170 382014 109552 13830 105722 27219 225997 233979 11419 246788 229933 23844 63873 26373 99663 12733 26372 56365 20276 14628 233246 94178 20277 76757 338370 20278 277328 404545 279561 171382 107568 320091 382427 101772 232341 140475 22368 170755 14605 69847 22190 102566 193034 667035 12723 241118 24115 75607 65973 12727 226025 12725 22063 58800 12728 68667 12724 22065 78339 20393 194352 208169 56843 117160 22066 229277 20191 171166 20192 22068 640703 64177 22067 28240 110157 252972 14226 20190 PHASE II CONJUGATION%REACTOME DATABASE ID RELEASE 57%156580 Phase II conjugation 231583 117147 94215 238505 210009 23972 23971 13077 67768 108645 269378 18113 29859 23827 108652 11720 94284 56362 394436 17960 216558 20887 552899 22017 17961 57344 100559 394433 20860 71773 213012 231396 232087 22236 76491 22235 242585 100727 394434 12846 73836 13521 14859 54486 69065 68214 68312 207182 23887 66447 14630 14862 14873 71522 14865 68044 67674 14866 68252 14629 58810 14874 75475 233801 14863 272428 14854 107146 66054 20859 233799 13885 100042314 14598 76263 435528 14872 14871 211666 56615 RETROGRADE NEUROTROPHIN SIGNALLING%REACTOME DATABASE ID RELEASE 57%177504 Retrograde neurotrophin signalling 54152 12757 11772 232910 20404 11773 13430 18049 11771 103967 18211 67300 71770 13429 PRE-MRNA SPLICING%REACTOME%R-HSA-72163.1 pre-mRNA splicing 193116 110809 225027 60365 67337 228410 68219 19826 67996 20382 51786 77134 71713 56194 15568 238831 67480 233073 69207 108014 18521 17149 100040029 192160 67332 20638 20641 66441 54196 54451 384091 64340 107686 192170 66899 622469 51796 21681 18789 666609 20383 68134 269061 22608 53379 13207 230596 54723 56258 233908 53607 14105 66101 107701 59013 68479 70052 70767 15388 13204 68988 51810 60321 81898 20227 11991 330361 232989 67439 66585 98758 57905 98985 72198 319322 70233 83701 27366 76938 101943 94315 212880 15569 54633 19655 27967 76522 53317 66094 68592 66877 67678 11834 66070 192159 67958 13211 15382 50783 75062 72047 28035 78651 229279 66618 28000 67710 17749 66420 245841 20021 69241 66055 70616 20624 66373 23983 20637 20630 67465 56031 94230 15381 67500 22668 68981 76936 75956 71702 74351 22380 66125 15481 68816 19205 20639 20462 67959 68598 20646 80744 68092 100040177 69833 209416 68705 433702 54188 69192 20022 108062 74326 69920 66642 68879 231329 76479 98053 68183 66810 320632 100043714 83486 20020 27756 67285 20222 15387 TRKA ACTIVATION BY NGF%REACTOME DATABASE ID RELEASE 57%187042 TRKA activation by NGF 18049 18211 CERAMIDE SIGNALLING%REACTOME%R-HSA-193681.1 Ceramide signalling 18049 18053 20598 THE RETINOID CYCLE IN CONES (DAYLIGHT VISION)%REACTOME DATABASE ID RELEASE 57%2187335 The retinoid cycle in cones (daylight vision) 14539 12057 19661 20148 19771 MAP KINASE ACTIVATION IN TLR CASCADE%REACTOME%R-HSA-450294.2 MAP kinase activation in TLR cascade 19094 110651 12234 17164 26965 72349 20111 12912 26400 26417 26413 23939 20112 257632 26420 107607 11909 16476 17260 13712 26414 22190 108960 26395 26409 667035 26398 26397 192656 19052 67603 19053 100040260 73699 319520 68652 26419 21402 66724 22034 102626 66513 17258 51792 103583 26416 21770 12675 18033 26399 231130 16151 73086 16150 14281 26410 235584 16179 ISG15 ANTIVIRAL MECHANISM%REACTOME DATABASE ID RELEASE 57%1169408 ISG15 antiviral mechanism 218210 66679 18226 100039592 69912 227720 54563 22194 223921 103468 16211 70699 16648 16649 72787 54131 74153 16451 269113 231042 234865 69736 19069 16646 107939 66892 170762 230861 112419 23806 17999 13690 24110 19043 26417 286940 59015 227699 18141 208643 192170 445007 108989 19386 69482 71805 56791 100038882 22190 667035 18803 13684 217069 13682 93765 20846 13681 23988 19106 381686 230073 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION%REACTOME%R-HSA-381340.2 Transcriptional regulation of white adipocyte differentiation 56406 11450 109151 20933 19017 80509 67219 19016 67279 11770 229003 19013 19014 23989 69790 13591 22408 13654 17979 68975 70625 234959 70208 76199 264064 17978 28077 103968 171285 16956 56771 12608 20181 66999 16846 57875 17977 12914 20185 20602 328572 20528 66172 21926 81004 75613 12491 94112 12567 21803 12609 12606 26896 21372 16600 22410 69792 15183 11819 51813 12445 12224 381379 67224 66993 78334 18534 59024 59035 216154 19697 18033 20788 327987 67381 192191 108098 SUMO IS TRANSFERRED FROM E1 TO E2 (UBE2I, UBC9)%REACTOME%R-HSA-3065678.1 SUMO is transferred from E1 to E2 (UBE2I, UBC9) 50995 56459 22196 100043429 20610 G ALPHA (S) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 57%418555 G alpha (s) signalling events 216869 109689 20287 11517 14706 14607 14678 14696 14677 14526 19219 14679 14527 11516 14602 14688 14708 235036 14693 14709 14601 14697 11555 12640 242851 16866 12000 22094 54598 14699 66066 14700 14701 14695 93896 14652 14704 14702 381853 14710 64337 14308 104110 17200 15562 15566 15565 51801 223780 11535 12311 12310 56089 15874 54409 207728 23984 11998 320129 14773 16867 18573 381413 319239 19214 80910 224129 14309 238725 11513 11512 212108 100043254 11515 22353 11514 17202 17199 17201 17203 26385 22095 209512 71223 215855 114640 218461 22354 16336 241489 54611 93690 18576 110355 382348 18976 18574 15466 110385 18577 13492 210044 19228 213527 432530 238871 19773 12922 104111 14608 18583 11540 18584 18578 13488 239530 215854 29863 12918 14761 227289 19226 11541 111174 12921 22355 19217 19227 383563 381489 503558 19222 11554 14687 11556 140498 SIGNALING BY ERBB2%REACTOME DATABASE ID RELEASE 57%1227986 Signaling by ERBB2 75717 12223 56424 211323 20459 100042150 13367 11848 22190 13645 14786 667035 18803 18176 20662 12539 59079 20779 76890 11652 17179 19248 67588 11651 18183 22612 15461 20416 13874 83961 18708 23797 15200 18706 15519 14388 13866 13649 14360 16653 84092 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM%REACTOME DATABASE ID RELEASE 57%2046104 alpha-linolenic (omega3) and linoleic (omega6) acid metabolism 20280 68801 54326 56473 170789 11666 113868 12686 76267 15488 54325 14081 DEFECTIVE CFTR CAUSES CYSTIC FIBROSIS%REACTOME DATABASE ID RELEASE 57%5678895 Defective CFTR causes cystic fibrosis 67819 66753 19186 19188 269523 57296 67151 66413 19185 66998 53380 19192 20338 26445 17463 19166 12638 69077 193670 54197 26444 116891 26446 216440 26443 22123 59029 19184 19179 22190 20422 667035 19182 19181 23997 66997 16913 228769 70247 19175 67089 19177 19170 21762 23996 103554 16912 19173 19172 244373 73902 19167 26441 19171 70377 26442 226144 26440 ESTROGEN BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 57%193144 Estrogen biosynthesis 114664 15486 15485 66065 13075 14187 PPARA ACTIVATES GENE EXPRESSION%REACTOME%R-HSA-1989781.2 PPARA activates gene expression 12896 56406 12894 109151 14080 20933 80509 21677 67219 11806 15360 100040592 229003 11303 17764 11807 23989 69790 170826 17979 18181 76199 28077 76267 66999 19731 57875 394434 12914 328572 11364 75613 11655 12491 94112 14137 18631 20683 21372 14219 381379 66993 12753 73690 17436 59024 22601 216154 195733 20788 327987 20859 14200 108098 217166 18045 94185 18670 14081 26379 19017 26457 11520 19016 67279 19013 66113 19014 11606 100040843 68975 13122 70625 234959 19883 70208 264064 17978 20186 171285 56771 18046 20181 17977 18044 20185 11865 66172 107765 81004 21678 21679 21676 18143 26896 228775 15183 13076 69792 51813 67224 78334 24001 59035 14373 50493 67381 97064 192191 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME DATABASE ID RELEASE 57%975144 IRAK1 recruits IKK complex upon TLR7 8 or 9 stimulation 16151 67245 16150 22034 93834 66589 93765 240518 12675 16179 CASP8 ACTIVITY IS INHIBITED%REACTOME DATABASE ID RELEASE 57%5218900 CASP8 activity is inhibited 22030 14082 21933 14102 14103 22035 12370 71609 19766 PI-3K CASCADE:FGFR2%REACTOME%R-HSA-5654695.1 PI-3K cascade:FGFR2 211323 13645 18183 12576 12575 74769 18707 18709 16367 13866 14360 14186 19052 14170 19053 73699 51792 13874 56637 83961 21770 26932 226849 26931 225849 384783 12675 67112 13649 18595 18591 12223 16334 76850 100042150 236511 19247 16337 75778 15370 327826 12519 12524 18710 14172 12912 26417 26413 606496 244650 12015 56717 22084 77647 239528 12371 98432 16590 117150 64654 56458 14173 56484 80903 14164 213988 11652 18717 12478 11651 15937 14178 80857 14180 78757 228775 12487 14175 14177 217351 14165 18596 233833 23797 18708 15200 67605 18706 18720 17246 56716 16818 18719 214150 108083 83379 18607 14388 22324 14174 19211 227743 18718 109270 17454 58988 DEATH RECEPTOR SIGNALLING%REACTOME%R-HSA-73887.1 Death Receptor Signalling 22030 74256 53376 229603 30941 11491 14082 22190 21937 21933 21926 14102 26409 22258 14103 667035 12370 11797 22035 71609 19766 21929 76686 432940 68652 11796 66724 66513 20598 12633 24105 52440 268749 22029 66552 73218 67384 106025 58994 12675 16151 16150 18201 14694 11798 PCNA-DEPENDENT LONG PATCH BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 57%5651801 PCNA-Dependent Long Patch Base Excision Repair 18973 11792 19687 69263 18970 67967 16881 19718 14156 18972 18538 19891 69745 68240 18971 59001 72151 106344 66979 18974 68275 FGFR3 MUTANT RECEPTOR ACTIVATION%REACTOME%R-HSA-2033514.1 FGFR3 mutant receptor activation 64654 80903 14173 14164 14184 14172 80857 14180 14175 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE%REACTOME%R-HSA-166016.1 Toll Like Receptor 4 (TLR4) Cascade 16803 54131 21353 26965 56489 329547 13430 103967 17084 266632 26420 107607 11909 16476 17260 13712 434174 14082 26414 26395 26401 26398 12370 26397 192656 19766 17874 12491 19052 67603 19053 100040260 73699 319520 12229 26419 21402 11820 102626 20203 17258 24058 93765 51792 12703 26940 103583 21898 73914 106759 142980 26416 225471 56532 21770 12675 19697 21899 18033 26399 18036 231130 18035 17087 16151 18034 73086 16150 67245 93834 13211 66589 14281 24088 26410 21897 235584 16179 19247 22031 11797 100041766 216080 66105 19094 11796 11596 110651 12475 20210 117149 12234 17164 72349 20111 12912 26400 26417 240518 26413 23939 20112 257632 56480 54123 22190 108960 26409 667035 234779 68652 17079 66724 22034 13429 66513 16409 16414 SYNTHESIS OF BILE ACIDS AND BILE SALTS%REACTOME DATABASE ID RELEASE 57%192105 Synthesis of bile acids and bile salts 12012 26459 83702 13123 13116 12642 19223 13122 17978 17117 104086 20186 170789 77337 26458 105349 101502 208665 20181 15488 56050 13124 27413 93732 17977 VITAMIN B1 (THIAMIN) METABOLISM%REACTOME DATABASE ID RELEASE 57%196819 Vitamin B1 (thiamin) metabolism 105663 116914 29807 BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME%R-HSA-70895.2 Branched-chain amino acid catabolism 192289 12040 12036 12039 12035 72039 11992 56752 15108 104776 20425 13171 78038 170442 12041 66885 243382 58875 66948 56357 227095 110446 13382 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES%REACTOME%R-HSA-382551.1 Transmembrane transport of small molecules 330064 66753 214922 30791 67547 106947 72002 213053 106957 14977 227059 14706 72027 14696 14688 14708 14693 14709 14697 21366 20538 240332 110877 103098 102680 22598 104245 14664 56774 20513 22348 110893 20517 20512 26905 20511 63993 242607 67204 74338 13162 20541 67760 14699 66066 14700 14701 14695 214084 14704 20510 14702 20518 14710 64337 70377 20927 226144 68428 19186 19188 57296 20928 67151 19185 66998 53380 17463 69077 16514 110891 12323 108058 12322 59029 19184 19179 20422 19182 19181 23997 66997 70840 228769 20521 70247 18400 67089 108114 20519 30805 21762 20520 23996 242126 19879 20500 80879 18399 67473 640703 57274 237831 12325 20501 114644 20503 55961 75750 12215 73902 243755 13723 83814 11826 66413 11806 28250 28253 76408 19192 26445 19166 77706 74998 11831 15561 11832 26444 17339 26446 27404 11830 26443 11829 59049 16819 66333 12780 27421 11827 239273 17919 24014 14628 14395 15368 94178 15369 235574 73649 26357 338370 52466 14394 74610 404545 24015 50770 14325 74104 14397 226844 54667 56199 14399 56325 11982 64008 110886 11828 74915 18671 54670 22123 208760 14396 12000 14401 14402 14408 14407 11931 140475 170755 14400 21871 236915 102566 193034 14406 241118 24115 65973 226025 224742 22063 67470 58800 11833 328699 224814 100039636 27409 14409 22065 18173 194352 16913 11928 208169 19175 56843 19177 11307 69047 117160 19170 232975 56636 98660 192113 11966 103554 22066 16912 229277 76295 56017 170759 20191 19173 171166 19172 20192 22068 67331 11973 64177 22067 11964 110935 28240 11932 110157 11938 19167 14658 26441 53313 14654 11937 19171 237213 252972 11980 381290 320707 26442 67972 26440 14226 57014 20190 11933 26874 243634 19088 27403 110304 217265 72621 19299 105355 11305 217843 217262 97086 19298 17364 74591 66290 108664 212989 26946 320940 68279 104110 74772 74446 57780 59095 56407 58170 66388 382014 109552 268878 11974 13830 105722 242341 27219 11945 11944 225997 11941 233979 114143 13665 11975 11419 246788 11972 68775 229933 66237 23844 63873 54411 26373 99663 12733 26372 231287 56365 20276 233246 66144 20277 11518 76757 20278 277328 11977 224079 338375 279561 66335 76252 56535 171382 76184 107568 108017 192663 320091 382427 101772 56188 232341 224129 11981 22368 11513 14605 11512 69847 27060 11515 57249 11514 73834 140494 12723 319767 75607 20537 12727 14385 12725 14377 11979 64452 12728 231103 14657 20526 68667 56485 12724 78339 50769 50771 18747 18749 210044 432530 104111 20525 68401 230612 246787 14378 53881 20527 19087 19085 19084 11657 231583 14319 70484 235504 236727 331004 77031 236794 105243 277973 226999 110895 74051 71279 58246 24059 50934 30962 240215 170441 23985 269346 20544 56643 20498 330836 434203 20540 317750 20495 108652 20497 20496 229782 57738 54403 435818 27376 11304 24060 27416 73836 13521 80286 15275 15277 212032 18716 269523 83429 11815 214112 77701 380836 26569 74552 26457 142681 225579 227659 77704 233280 70701 12007 223473 236792 13829 93790 27360 11519 11732 11998 53869 239436 11989 230810 114304 66500 11416 53945 65221 107723 76376 108115 20528 22190 215113 53896 171429 667035 59033 69048 94229 22782 72401 22784 218756 210148 216225 20515 246049 20504 238384 20535 94249 20532 338365 22041 26570 20516 215335 22232 18174 22042 320718 20499 13487 20536 20514 12870 15203 63959 216227 227394 353169 20533 69354 67582 13340 100561 55963 17254 244373 232156 117591 57138 101488 209837 58807 98396 140919 243328 170756 11987 20529 76257 72045 114479 208890 20539 67075 243616 14411 14412 232333 17250 105727 242585 242259 68682 27411 58176 70129 108052 56315 19743 100434 213603 218210 67819 66679 18226 69912 18670 227720 54563 223921 103468 70699 72787 103988 269113 231042 20338 234865 69736 12638 19069 107939 170762 193670 20531 54197 116891 216440 20505 27410 59015 227699 214111 18141 233836 239606 445007 108989 19386 69482 71805 11666 20393 228368 GLUCOCORTICOID BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 57%194002 Glucocorticoid biosynthesis 15483 15492 15497 13072 110115 13074 13079 15484 18976 ELASTIC FIBRE FORMATION%REACTOME%R-HSA-1566948.1 Elastic fibre formation 216760 16416 16420 17150 16402 21808 18550 12154 16998 14115 100034361 58859 12159 94352 12162 320910 12156 16950 67573 76293 216616 241226 13717 268977 14118 21803 14563 50530 108075 14114 14119 21809 16997 23876 22370 16419 16948 16949 16412 16410 PI-3K CASCADE:FGFR4%REACTOME DATABASE ID RELEASE 57%5654720 PI-3K cascade:FGFR4 211323 13645 18183 12576 12575 74769 18707 18709 16367 13866 14360 14186 19052 14170 19053 73699 51792 13874 56637 83961 21770 26932 226849 26931 225849 384783 12675 67112 13649 18595 18591 12223 16334 76850 100042150 236511 19247 16337 75778 15370 327826 12519 12524 18710 14172 12912 26417 26413 606496 244650 12015 56717 22084 77647 239528 12371 98432 16590 117150 64654 56458 14173 56484 80903 14164 213988 11652 18717 12478 11651 15937 14178 80857 14180 78757 228775 12487 14175 14177 217351 14165 18596 233833 23797 18708 15200 67605 18706 18720 17246 56716 16818 18719 214150 108083 83379 18607 14388 22324 14174 19211 227743 18718 109270 17454 58988 INTERACTIONS OF TAT WITH HOST CELLULAR PROTEINS%REACTOME%R-HSA-176034.1 Interactions of Tat with host cellular proteins 107951 12455 HHAT G278V ABROGATES PALMITOYLATION OF HH-NP%REACTOME%R-HSA-5658034.1 HHAT G278V abrogates palmitoylation of Hh-Np 13363 20423 16147 MRNA 3'-END PROCESSING%REACTOME DATABASE ID RELEASE 57%72187 mRNA 3'-end processing 193116 107829 110809 225027 60365 331401 66511 68278 67337 228410 68219 19826 67996 73666 20382 53817 51786 71713 70579 66231 69823 233073 73826 69207 108014 386612 94230 17149 100040029 192160 625193 225160 68092 66441 54196 54188 433702 54451 108062 64340 192170 66899 622469 51796 21681 18789 20383 68134 269061 98985 PENTOSE PHOSPHATE PATHWAY (HEXOSE MONOPHOSPHATE SHUNT)%REACTOME DATABASE ID RELEASE 57%71336 Pentose phosphate pathway (hexose monophosphate shunt) 110208 66681 66171 21881 21351 232449 19895 14381 66646 AXIN MUTANTS DESTABILIZE THE DESTRUCTION COMPLEX, ACTIVATING WNT SIGNALING%REACTOME%R-HSA-4839735.1 AXIN mutants destabilize the destruction complex, activating WNT signaling 11789 56637 93687 72345 21770 26932 226849 12005 26931 225849 19052 19053 73699 51792 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION%REACTOME DATABASE ID RELEASE 57%2173796 SMAD2 SMAD3:SMAD4 heterotrimer regulates transcription 107951 17131 12454 17283 22190 21815 667035 93836 228839 20683 13559 104394 17869 51813 12579 211586 17127 17128 19650 433759 17126 21781 264064 16477 67821 97064 72949 12455 18787 ACTIVATION OF THE TFAP2 (AP-2) FAMILY OF TRANSCRIPTION FACTORS%REACTOME%R-HSA-8866907.1 Activation of the TFAP2 (AP-2) family of transcription factors 21418 226896 12914 64050 56222 328572 12705 332937 17684 21420 80707 21419 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS%REACTOME DATABASE ID RELEASE 57%1362409 Mitochondrial iron-sulfur cluster biogenesis 246696 68165 380840 14297 67712 14148 14149 TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN CYTOCHROME C RELEASE%REACTOME DATABASE ID RELEASE 57%6803204 TP53 Regulates Transcription of Genes Involved in Cytochrome C Release 22062 68428 21981 12914 12122 71361 60599 69076 22059 225655 12177 12028 11920 66494 209456 22061 IRON UPTAKE AND TRANSPORT%REACTOME DATABASE ID RELEASE 57%917937 Iron uptake and transport 68428 53945 14319 66290 108664 21871 27060 73834 140494 100039636 11974 22041 242341 18174 22042 74051 114143 11966 11975 12870 15203 68775 11972 66237 59049 16819 54411 11973 11964 110935 15368 15369 66144 94178 73649 26357 52466 14325 226844 338375 66335 76252 74915 NEF MEDIATED DOWNREGULATION OF CD28 CELL SURFACE EXPRESSION%REACTOME DATABASE ID RELEASE 57%164939 Nef mediated downregulation of CD28 cell surface expression 12487 11773 THE NLRP3 INFLAMMASOME%REACTOME%R-HSA-844456.1 The NLRP3 inflammasome 56338 22166 15516 66824 54483 11820 67955 216799 55991 19200 12362 18439 G0 AND EARLY G1%REACTOME DATABASE ID RELEASE 57%1538133 G0 and Early G1 19646 18538 12427 13548 21973 13559 12447 104394 211586 19651 12448 19650 433759 75660 17865 13555 21781 629959 12534 23834 12566 12530 231506 72568 12428 VASOPRESSIN REGULATES RENAL WATER HOMEOSTASIS VIA AQUAPORINS%REACTOME%R-HSA-432040.1 Vasopressin regulates renal water homeostasis via Aquaporins 12000 53869 19088 224129 11513 11512 11826 11515 11514 104110 14706 14696 14688 14708 14693 14709 18747 14697 14699 66066 18749 74998 14700 14701 210044 432530 11829 14695 104111 11998 14704 14702 11827 14710 17919 64337 19087 19085 19084 11828 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 57%2691230 Signaling by NOTCH1 HD Domain Mutants in Cancer 11487 225164 240055 11491 22190 76580 18011 667035 54485 13388 16450 16449 18128 ABASIC SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME%R-HSA-73930.1 Abasic sugar-phosphate removal via the single-nucleotide replacement pathway 11792 18970 CLASS II GLUTS%REACTOME DATABASE ID RELEASE 57%428776 Class II GLUTs 117591 435818 56485 RAF-INDEPENDENT MAPK1 3 ACTIVATION%REACTOME%R-HSA-112409.1 RAF-independent MAPK1 3 activation 16194 16193 19247 54721 26395 18611 26417 16452 26413 67603 70686 12534 319520 63953 26396 75590 19252 16451 240672 13537 235584 18218 CLEC7A (DECTIN-1) SIGNALING%REACTOME%R-HSA-5607764.1 CLEC7A (Dectin-1) signaling 108723 53859 18753 20963 19186 19188 229709 100041766 216080 56644 57296 67151 66413 19185 66998 53380 12042 19192 26445 17463 19166 216150 69077 18018 18019 26444 12234 26446 26443 26965 18021 22192 16176 22123 22200 66824 59029 19184 332579 19179 22190 20422 26409 667035 19182 12370 19181 234779 23997 19056 66997 19055 68652 21402 66724 22034 66513 16913 240354 228769 16440 93765 70247 19175 67089 19177 103583 19170 21762 23996 16438 103554 16912 19173 19172 640703 12675 19697 18033 19058 73902 18035 19167 18607 16151 26441 18034 19698 16150 19171 66589 26442 26440 16439 SCAVENGING BY CLASS F RECEPTORS%REACTOME%R-HSA-3000484.1 Scavenging by Class F Receptors 15505 380713 12317 12282 238055 15519 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY%REACTOME DATABASE ID RELEASE 57%2173795 Downregulation of SMAD2 3:SMAD4 transcriptional activity 19042 66313 22284 11545 20482 17127 20185 17128 433759 20602 17126 22190 83814 21815 20481 93836 667035 228839 216080 66105 94093 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION%REACTOME%R-HSA-416550.1 Sema4D mediated inhibition of cell attachment and migration 232906 19353 20130 235611 17295 11848 20354 223881 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2%REACTOME%R-HSA-5140745.1 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 14367 74325 22418 12757 11772 57265 232910 11773 11771 67300 71770 26564 26563 REGULATION OF ORNITHINE DECARBOXYLASE (ODC)%REACTOME%R-HSA-350562.1 Regulation of ornithine decarboxylase (ODC) 19186 19188 57296 67151 66413 19185 66998 53380 19192 17463 26445 19166 69077 26444 26446 26443 22123 59029 19184 19179 20422 19182 19181 23997 66997 16913 228769 19175 70247 19177 67089 19170 21762 23996 18263 103554 53814 16912 19173 19172 73902 19167 26441 19171 26442 26440 18104 18247 18245 54375 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA%REACTOME DATABASE ID RELEASE 57%1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha 13819 22346 71745 112406 112407 53417 15251 22190 667035 100041766 216080 66105 56438 67923 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+%REACTOME%R-HSA-76005.1 Response to elevated platelet cytosolic Ca2+ 13645 14268 11806 22145 21857 20909 12631 20692 239273 232345 268373 21808 22339 11674 12527 21825 12491 22138 11820 21803 21809 22330 99571 215789 11804 27359 223601 12331 67988 21859 20363 75396 74145 11537 12759 14069 11472 18613 14067 18591 18750 66866 19156 16416 20912 109232 20255 74840 14828 20344 21767 19073 21894 80884 13601 108101 16784 18752 21346 56541 117586 67059 20716 268936 16000 14161 22388 18751 80718 16002 94175 26968 11747 11625 227612 19039 71946 13041 667310 15234 240334 68038 18407 16427 12512 218454 104009 18816 53612 20703 12321 20911 72017 22341 67072 16426 235505 22340 57349 56744 11818 54216 21922 60595 27999 56055 12258 385643 71660 68117 320202 14205 56193 70945 14456 18643 19128 110135 22041 192176 109711 16399 640703 22371 18815 11657 18787 NUCLEAR ENVELOPE REASSEMBLY%REACTOME%R-HSA-2995410.1 Nuclear Envelope Reassembly 19052 71978 71782 16906 22367 51792 380664 224640 13726 23825 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA%REACTOME DATABASE ID RELEASE 57%212718 EGFR interacts with phospholipase C-gamma 18750 19088 18573 18753 224129 18754 11513 11512 11515 13645 11514 18752 104110 229709 18803 12326 16440 110355 18747 18574 16438 18749 210044 18575 432530 104111 12912 640703 19087 19085 19084 13649 16439 TOXICITY OF BOTULINUM TOXIN TYPE F (BONT F)%REACTOME DATABASE ID RELEASE 57%5250981 Toxicity of botulinum toxin type F (BoNT F) 75209 64176 22318 22317 64051 SUMOYLATION OF RNA BINDING PROTEINS%REACTOME DATABASE ID RELEASE 57%4570464 SUMOylation of RNA binding proteins 218210 13619 66679 12418 18226 241915 69912 54383 227720 54563 223921 103468 70699 72787 30951 100043429 269113 231042 234865 69736 19069 15381 107939 170762 22196 19821 19763 55989 12416 22658 59015 227699 18141 12151 445007 108989 19386 15387 69482 71805 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS)%REACTOME DATABASE ID RELEASE 57%70221 Glycogen breakdown (glycogenolysis) 72157 14387 77559 640703 66681 102093 68961 110094 18679 18682 27357 110078 110095 19309 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS%REACTOME DATABASE ID RELEASE 57%442742 CREB phosphorylation through the activation of Ras 12323 108058 13385 12322 19417 18039 20130 15461 14812 110651 109880 14811 20111 14813 640703 100986 12912 14814 12325 26413 20112 110157 18607 67071 11472 14810 19418 SYNTHESIS OF PG%REACTOME DATABASE ID RELEASE 57%1483148 Synthesis of PG 18806 74451 66461 104759 18807 18805 110911 NONSENSE-MEDIATED DECAY (NMD)%REACTOME DATABASE ID RELEASE 57%927802 Nonsense-Mediated Decay (NMD) 60365 19826 17149 76808 68028 100043755 19899 71978 67186 20115 57294 667739 192160 67025 27370 65019 67248 666669 100038991 100038875 100040021 66441 192170 432502 66481 100040298 238217 56040 68134 667618 19989 103677 19052 51792 71997 226517 229512 74133 14852 68092 225363 19704 433702 208643 326622 14853 67031 18458 67891 100042986 100042740 621100 100043295 67097 100043000 625646 67281 633683 233789 667035 666899 16785 100039316 267019 100040970 19941 382492 20055 19951 100042670 68193 665189 668182 19921 20044 668144 100043423 100043893 670832 100043876 629957 225058 22121 75617 667279 76846 27050 100043184 19934 100040331 100043391 319195 68172 241053 100043209 20102 67941 27207 668668 20103 672214 622534 20085 20084 SYNTHESIS OF IPS IN THE NUCLEUS%REACTOME%R-HSA-1855191.2 Synthesis of IPs in the nucleus 69718 27399 76500 75678 SYNTHESIS OF PS%REACTOME DATABASE ID RELEASE 57%1483101 Synthesis of PS 27388 19210 KERATAN SULFATE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 57%2022854 Keratan sulfate biosynthesis 53625 70484 14595 76969 72297 56386 57370 231727 56375 53418 56336 14264 18295 27047 116847 16545 17022 54613 54371 108902 227327 20442 20443 56773 20444 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY%REACTOME DATABASE ID RELEASE 57%69656 Cyclin A:Cdk2-associated events at S phase entry 22390 19186 19188 57296 67151 66413 19185 66998 53380 19192 26445 17463 19166 69077 12576 17187 26444 12448 26446 26443 26965 12572 19645 12575 17420 12531 12566 27401 22123 59029 20459 19184 19179 22190 20422 667035 56371 19182 12427 19181 23997 66997 21402 12567 16913 12447 12443 228769 70247 19175 67089 19177 17869 66671 19170 54124 21762 23996 16912 19173 19172 19167 26441 19171 12530 26442 26440 12428 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 27-HYDROXYCHOLESTEROL%REACTOME%R-HSA-193807.1 Synthesis of bile acids and bile salts via 27-hydroxycholesterol 19223 13122 83702 13123 17978 104086 20186 77337 105349 101502 208665 20181 13124 17977 DNA REPLICATION%REACTOME DATABASE ID RELEASE 57%69306 DNA Replication 18973 19687 69263 67967 19718 18972 18538 19891 69745 68240 18971 66413 19192 26445 19166 12576 26444 26446 26443 13557 19645 12575 13555 59001 72151 106344 66979 242705 18974 68275 22123 57441 56371 16913 50793 19175 19177 19170 103554 16912 19173 19172 19167 26441 19171 26442 26440 70024 19186 19188 57296 67151 27214 19185 66998 53380 18392 26428 18393 17463 26429 69077 327762 16881 14156 12544 12545 12566 109145 272551 78833 69270 59029 18969 19075 19184 22190 19179 20422 667035 19182 12427 19181 23997 66997 228769 70247 67089 21762 23996 17215 17219 17217 56452 66634 67177 73902 23834 17216 18968 19076 17220 12428 17218 MITOCHONDRIAL ABC TRANSPORTERS%REACTOME%R-HSA-1369007.1 Mitochondrial ABC transporters 74610 74104 56199 PROGRESSIVE TRIMMING OF ALPHA-1,2-LINKED MANNOSE RESIDUES FROM MAN9 8 7GLCNAC2 TO PRODUCE MAN5GLCNAC2%REACTOME DATABASE ID RELEASE 57%964827 Progressive trimming of alpha-1,2-linked mannose residues from Man9 8 7GlcNAc2 to produce Man5GlcNAc2 17156 230815 17155 AMPLIFICATION OF SIGNAL FROM UNATTACHED KINETOCHORES VIA A MAD2 INHIBITORY SIGNAL%REACTOME DATABASE ID RELEASE 57%141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal 17120 56150 MEMBRANE TRAFFICKING%REACTOME%R-HSA-199991.3 Membrane Trafficking 56455 104318 18472 13430 103967 13427 13424 17274 69654 22318 53598 11820 20508 12504 21787 18195 53334 78232 12068 56389 66111 207352 13429 640703 17884 194309 17883 16554 66914 209737 17885 194590 17113 69834 16564 20740 215890 11772 20739 26951 107305 13645 20616 20932 17879 216869 67023 109689 66147 68938 224630 11771 54214 216705 71770 12121 19159 20955 57915 225152 21987 19158 75608 19157 66201 27277 27681 76959 214459 238055 56044 210108 70218 353155 211446 20336 74741 270192 53413 215114 12757 70646 232910 80297 30948 67602 11773 72318 20742 218038 102058 18457 20741 20743 667772 118454 11774 14325 14623 75985 19348 16561 18476 16835 26895 12000 80912 23970 330192 14620 20479 229521 14622 228998 16571 56494 30931 50907 15463 242406 14616 68953 14618 14619 14613 14611 109181 27059 14725 105504 67300 640524 29816 12492 26754 66397 70297 100017 26893 54609 94245 11782 23969 14533 67474 16568 52348 14612 66700 16570 16572 54401 56017 22088 73804 224705 74764 74438 71116 116733 14610 56085 105513 56382 270160 210789 110033 286942 208092 105245 245638 231580 227746 76895 140781 66371 13649 17888 229841 16593 58244 66905 77929 16551 16334 13858 13854 20404 105785 13191 15481 69162 243764 70160 107371 319642 66691 232286 11652 18717 11651 21872 110355 16581 14269 27096 73124 235416 69178 13543 14319 16565 11842 67542 22418 108679 11839 76688 668303 252903 12402 66616 53330 11840 74947 77371 59288 245828 11555 20619 56378 17913 22320 20909 11844 22319 17156 66713 53357 70349 12847 74498 14366 56358 19353 67857 213575 108123 108124 213827 21802 22627 11843 12794 20980 234663 70361 22428 217615 67511 102339 317717 60510 68137 20979 72685 20912 20661 240028 80708 16563 16573 76899 233824 54161 74375 11781 100039786 78689 66251 104215 72772 108011 13423 170625 16569 77038 20615 11607 19324 12500 226089 16562 71819 26891 28169 240641 68299 232943 108800 56447 117197 100043806 16552 55948 14615 20703 56367 108012 18783 11768 55925 22631 230815 13132 22629 11766 22628 11998 106628 320129 52036 12848 11767 16004 26934 19325 76983 13855 76932 66682 13043 21336 544791 99683 53611 232946 20403 67489 104303 11765 11764 68505 53869 224139 233489 99412 19707 76308 228850 89867 14617 16560 218503 108148 16579 22190 20528 14423 11845 75612 13032 667035 28084 338366 73296 19330 226407 269152 19346 17158 68328 20405 20975 19345 78304 18475 104015 67804 18704 19344 22041 97484 269774 75050 20408 73470 11733 13047 22042 14621 320634 11735 16443 73094 26894 30934 216131 76877 74325 17920 271457 243819 19341 11769 12836 11650 11777 59042 228421 12874 69940 18002 68365 56324 74015 105522 22365 14275 228960 26572 14609 66482 19338 319991 16558 13426 16594 245944 98910 66890 100042773 333883 193813 20333 67231 20844 107338 67091 110350 215474 69608 214895 76332 59005 108079 241113 15239 14069 338337 16834 67727 14067 20334 218811 76510 12793 108099 56395 19079 108097 19082 17155 12638 68097 54160 50797 56041 14799 56418 66226 110379 56443 227648 66913 64138 60409 17882 12502 17918 76709 73178 68089 74117 67665 67771 72978 54399 100042343 17957 TOXICITY OF BOTULINUM TOXIN TYPE G (BONT G)%REACTOME DATABASE ID RELEASE 57%5250989 Toxicity of botulinum toxin type G (BoNT G) 22318 22317 20979 SYNTHESIS OF UDP-N-ACETYL-GLUCOSAMINE%REACTOME%R-HSA-446210.2 Synthesis of UDP-N-acetyl-glucosamine 245847 14584 107652 56174 19703 54342 109785 14583 PERK REGULATES GENE EXPRESSION%REACTOME%R-HSA-381042.1 PERK regulates gene expression 14828 18045 64209 72662 74108 27998 69639 66583 66362 13666 16006 227715 13665 50911 27053 20293 72544 66446 109075 18046 226641 11910 11911 13198 70640 18044 RNA POLYMERASE I TRANSCRIPTION%REACTOME%R-HSA-73864.1 RNA Polymerase I Transcription 18519 17749 66420 12417 245841 319181 107932 66467 234366 232440 216848 106298 14884 23942 382522 319176 319955 433759 15182 12572 26417 17420 624153 69833 625328 51788 15077 319149 17191 100043714 245688 229542 66136 19285 116870 21341 21340 15267 110147 20017 319183 21374 70333 19646 667501 22130 319182 319178 319186 319190 21429 75316 64424 20016 14534 20018 20019 319168 21339 66671 319167 23894 17192 13871 13872 116871 209357 14885 319188 15270 319169 78303 MAPK1 MAPK3 SIGNALING%REACTOME%R-HSA-5684996.1 MAPK1 MAPK3 signaling 56438 26395 67603 319520 235584 26403 16416 12223 54519 100042150 21894 11600 19060 19186 19188 327826 17169 194231 109905 14161 226525 57296 67151 215449 19185 66998 53380 14172 17967 15461 17463 83409 69077 29875 26417 26413 12534 12323 108058 12322 18015 59029 19197 19417 19184 19179 22190 20422 171463 14573 667035 19182 16590 240057 19181 231474 64654 80903 14173 23997 14164 66997 18039 218397 110135 14585 14178 80857 228769 14180 70247 67089 14586 14587 14175 21762 14177 23996 20416 11876 14165 26554 18596 109880 16399 54153 15200 640703 18673 12325 16706 69601 83379 22371 73902 233046 114716 12981 19415 63953 14174 12982 19252 16653 12984 240672 13537 12988 67836 16186 13385 14588 211323 16184 11836 18188 20740 20739 13645 16185 16452 216869 109689 18176 72399 70686 114715 240168 14268 66413 211255 18183 14083 16451 19192 16453 26445 19166 18218 16194 14812 16193 76089 26444 26446 14811 26443 14813 19414 54721 80297 14814 16183 20742 20741 21687 20743 16367 13866 14810 16192 26396 14360 16191 216148 114713 14186 19418 22123 20662 19052 14170 19053 19262 73699 640524 16913 75590 19175 19177 51792 19713 19170 22330 99571 13874 103554 16912 54401 83961 16188 19173 19172 21770 26932 107971 226849 100986 18611 23980 26931 20418 225849 320484 384783 245684 67112 110157 19167 26441 19419 11472 19171 545987 13649 70727 18595 26442 26440 101809 18591 19247 PACKAGING OF TELOMERE ENDS%REACTOME DATABASE ID RELEASE 57%171306 Packaging Of Telomere Ends 15267 319183 319181 21750 319182 319178 319186 319190 232440 319168 382522 319167 319176 319152 497652 21749 624153 28113 101185 51788 57321 319188 15270 78303 319169 TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS%REACTOME DATABASE ID RELEASE 57%168271 Transport of Ribonucleoproteins into the Host Nucleus 218210 66679 18226 69912 227720 54563 223921 103468 70699 16211 72787 269113 231042 234865 69736 19069 16646 107939 170762 59015 227699 18141 445007 108989 19386 69482 71805 NADPH REGENERATION%REACTOME DATABASE ID RELEASE 57%389542 NADPH regeneration 15926 ERKS ARE INACTIVATED%REACTOME%R-HSA-202670.1 ERKs are inactivated 19052 67603 19053 73699 319520 72349 21770 26417 51792 26413 23939 235584 KSRP (KHSRP) BINDS AND DESTABILIZES MRNA%REACTOME%R-HSA-450604.2 KSRP (KHSRP) binds and destabilizes mRNA 50911 26416 22631 72662 74108 72544 66446 27998 69639 19094 66583 66362 11651 109075 70640 227715 DNA REPLICATION PRE-INITIATION%REACTOME DATABASE ID RELEASE 57%69002 DNA Replication Pre-Initiation 70024 18973 19186 19188 19891 68240 57296 67151 27214 66413 19185 66998 53380 18392 19192 26428 18393 26445 17463 26429 19166 69077 26444 26446 26443 13557 13555 12544 59001 12545 12566 242705 66979 18974 68275 22123 59029 18969 19075 19184 22190 19179 20422 57441 667035 19182 19181 23997 66997 16913 228769 50793 70247 19175 67089 19177 19170 21762 23996 17215 17219 103554 17217 16912 56452 19173 66634 19172 67177 73902 19167 23834 26441 19171 17216 18968 26442 19076 26440 17220 17218 PIP3 ACTIVATES AKT SIGNALING%REACTOME%R-HSA-1257604.4 PIP3 activates AKT signaling 211323 13645 18183 12576 12575 74769 18707 18709 16367 13866 14360 14186 19052 14170 19053 73699 51792 13874 56637 83961 21770 26932 226849 26931 225849 384783 12675 67112 13649 18595 18591 12223 16334 76850 100042150 236511 19247 16337 75778 15370 327826 12519 12524 18710 14172 12912 26417 26413 606496 244650 12015 56717 22084 77647 239528 12371 98432 16590 117150 64654 56458 14173 56484 80903 14164 213988 11652 18717 12478 11651 15937 14178 80857 14180 78757 228775 12487 14175 14177 217351 14165 18596 233833 23797 18708 15200 67605 18706 18720 17246 56716 16818 18719 214150 108083 83379 18607 14388 22324 14174 19211 227743 18718 109270 17454 58988 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%R-HSA-2122947.2 NOTCH1 Intracellular Domain Regulates Transcription 18519 12914 20185 328572 56233 20602 15251 22190 21888 21885 21886 667035 333639 81004 14534 21402 433586 21372 17869 103806 15183 51813 79221 170787 270118 208727 15208 433759 15205 26965 15213 15182 15185 232232 70315 56198 15214 15184 264064 19664 56438 18128 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII%REACTOME%R-HSA-442729.1 CREB phosphorylation through the activation of CaMKII 12323 14812 108058 13385 12322 14811 14813 12912 100986 640703 12325 14814 18039 11472 14810 CYTOKINE SIGNALING IN IMMUNE SYSTEM%REACTOME%R-HSA-1280215.2 Cytokine Signaling in Immune system 16362 230398 15977 54131 12010 14600 19116 12700 216233 16363 22192 56438 16176 266632 107607 26395 26398 192656 17874 67603 319520 13684 13682 93765 12703 103583 13681 73914 26399 231130 67245 93834 66589 26410 235584 16179 26403 16416 12223 54519 100042150 12504 21894 11600 19060 19186 19188 327826 17169 194231 109905 14161 226525 57296 67151 215449 18710 74153 19185 66998 53380 14172 17967 15461 17463 83409 69077 29875 12234 26417 240518 26413 208643 257632 22200 15979 12323 14469 108058 360213 12322 15975 18015 56791 224762 59029 15978 19197 100038882 16364 19417 15980 19184 15894 19179 20821 20422 171463 14573 15006 74735 19182 667370 16590 52668 240057 15958 19181 80890 231474 70110 80903 246727 23997 93679 66997 229644 18039 23960 218397 667803 246728 110135 20847 14585 236573 14178 56631 228769 69550 70247 101700 67089 15900 14586 55932 14587 231655 21762 229898 22329 23996 16391 20416 80876 11876 319236 14165 19824 26554 17318 18596 19204 109880 22670 23988 16399 229900 54153 66854 15200 56045 640703 67525 18673 55992 12325 13653 16818 58185 16706 66141 69601 94088 83379 22371 73902 233046 114716 19698 12981 19415 63953 14174 57444 12982 214158 19252 65972 16653 12265 12984 240672 13537 54139 12988 27056 21682 67836 16186 13385 14588 211323 16184 11836 20963 18188 20740 20739 13645 16185 16452 216869 109689 18176 72399 70686 114715 240168 14268 66413 211255 18183 14083 16451 19192 16453 26445 19166 16331 18218 16646 15170 16194 14812 16193 76089 16332 26444 26446 14811 19374 26443 19373 14813 54721 19414 80297 14814 74769 16183 20742 18707 24014 18709 20741 21687 20743 16367 13866 14810 16192 26396 14360 16191 216148 114713 14186 19418 22123 14103 20662 14170 19262 640524 16913 16165 75590 19175 209590 19177 12978 19713 20586 19170 12985 22330 69677 99571 54448 13874 103554 16912 54401 83961 16188 19173 19172 107971 100986 18611 23980 20418 320484 384783 245684 67112 110157 19167 26441 19419 11472 19171 545987 13649 70727 18595 26442 26440 19229 101809 18591 116849 16198 100039592 19152 76527 18753 16160 237310 11491 16197 19247 16161 12931 16175 17082 16199 16211 26406 16648 13019 93672 16649 20908 16155 16156 171095 16181 257630 237313 16172 16196 234836 338374 16880 57890 246779 140806 93871 16171 15234 50905 215274 12804 50498 12803 66892 16177 213208 16163 16162 230828 230861 16174 112419 329244 23806 18413 17999 16182 50931 13690 107527 19043 109658 286940 58181 16068 12986 56708 18414 54473 83430 218624 16178 15077 16173 14255 14256 16168 16878 319149 215257 242700 16159 100042555 16170 16169 12367 54123 12362 18803 18747 22324 19106 381686 19246 12402 20907 14991 17096 20909 240095 15007 12505 77125 14960 14968 14969 22030 21937 21926 217069 18383 245527 85030 230979 21938 57916 13608 21936 21940 56469 230073 22194 21948 240873 171211 21935 326623 22164 22163 13607 22631 22190 108960 26409 667035 64654 14173 14164 68652 66724 22034 66513 20848 80857 14180 20846 14175 14177 20851 17060 20850 14389 18708 18706 17750 12702 56417 16195 18854 26965 192170 69583 19052 19053 73699 21402 51792 21770 26932 226849 26931 225849 12675 19697 18033 16151 18034 16150 72049 218210 21947 66679 53859 18226 17000 69912 76500 227720 21934 19109 54563 22031 223921 24099 103468 21943 11797 70699 16992 27279 72787 50930 21944 11796 16994 269113 231042 234865 69736 19069 107939 170762 24110 59015 227699 18141 445007 108989 19386 69482 71805 12929 14129 18412 12928 22612 15162 107746 GLI PROTEINS BIND PROMOTERS OF HH RESPONSIVE GENES TO PROMOTE TRANSCRIPTION%REACTOME%R-HSA-5635851.2 GLI proteins bind promoters of Hh responsive genes to promote transcription 14632 14633 14634 CHK1 CHK2(CDS1) MEDIATED INACTIVATION OF CYCLIN B:CDK1 COMPLEX%REACTOME DATABASE ID RELEASE 57%75035 Chk1 Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex 12534 55948 54401 12532 22390 22631 22629 100039786 22627 22628 12649 METABOLISM OF PROTEINS%REACTOME%R-HSA-392499.3 Metabolism of proteins 20452 56455 104318 22145 20878 26370 13000 100039026 13427 13424 101565 69654 22153 227613 66235 53598 22142 55944 13669 27979 68135 66085 26905 22384 53356 56347 13684 67204 223691 217869 13682 73830 16341 100042807 13681 54709 75705 98221 52713 17390 13001 83995 18550 11806 11808 211446 20336 53413 17228 13035 102058 13033 11848 16322 16323 22094 105504 66397 16572 67674 14308 16324 16325 16326 11740 66248 107371 66174 209354 13667 217715 108067 20450 11540 11541 11739 226982 224045 66313 14678 14677 14679 20907 18442 56529 69019 13482 66286 236781 107221 18508 12640 242851 21416 18548 16866 16846 233081 66624 76687 78830 22030 74256 53376 229603 14447 30941 22258 12591 225642 19766 21929 50799 12447 12021 16573 319181 216080 15204 70681 240087 12189 17248 382522 70238 210766 27223 12448 22059 20184 269582 59004 22427 66826 12144 319183 319182 319178 319186 319190 12427 107976 68251 16392 69940 107995 12530 66482 319188 14681 15270 14685 14686 78303 14687 12428 12466 320183 12467 18537 12469 110265 76467 27361 12465 21454 12462 12461 12464 12468 12038 11423 66445 17304 69592 260302 20617 20219 20437 23821 13010 19109 67847 22031 21810 68396 11797 16432 106039 74105 75841 20698 11796 23802 66435 108687 20338 230899 22644 17002 66597 227619 15874 66967 193670 54197 223455 116891 320011 216440 22130 11461 17918 11946 11947 18815 100041835 16008 108077 14356 30055 56373 66411 12873 76703 27226 99371 100042179 18538 55946 30057 30059 19739 30839 66821 56327 66887 14706 24012 14607 100038824 14696 100900 14526 72061 213980 16010 12010 30838 14688 68033 14708 16005 14693 30050 14709 12856 56322 72170 14697 67105 76808 11421 68028 17714 100043755 11692 19899 16011 67186 16012 20115 73078 57294 66865 667739 242960 67025 67466 27370 50754 65019 50789 67248 70008 666669 30058 100038991 14943 100038875 16553 100040021 17380 17827 68653 100039174 70430 17713 23850 15526 108903 68275 21856 432502 626834 66481 71833 100040298 106052 238217 18491 56040 50762 667618 16790 19989 21371 13809 72726 107607 66525 22318 27055 636544 21855 192656 11820 14699 66066 14700 14701 14695 14704 14702 14710 64337 231130 13685 14828 18045 21894 19186 19188 14161 57296 67151 19185 66998 70325 53380 67241 17463 99349 20610 69077 21787 238024 53618 24070 14827 20210 18195 19821 108154 53334 13006 78232 74493 12068 214669 30940 56389 14422 107986 14852 15925 66111 225363 20842 218138 545260 208643 320713 257632 271786 14853 22224 18046 100683 12317 216725 226641 84092 22027 11504 11911 72607 13198 57357 18458 207352 18044 22166 56791 59029 19184 19179 20422 19182 19181 23997 66997 228769 70247 67089 21762 23996 20416 50779 70495 73902 433806 67713 68628 52815 30056 50782 12982 12984 234155 53375 66256 20740 67437 20739 20832 216869 109689 66413 19192 26445 19166 67768 26444 26446 26443 80297 20742 20741 20743 22123 56453 27362 67838 52808 78943 20818 228998 56494 50907 12282 64209 52639 66515 72662 74108 107513 640524 69639 270669 66583 74126 16913 19175 19177 19170 103554 16912 19173 19172 19167 26441 14297 19171 26442 26440 16334 16000 381801 28106 16002 56495 27998 67398 140740 66362 71853 11370 13666 192193 105785 16009 320209 16006 14583 227715 13191 13665 50911 12751 11972 57743 231997 27053 66212 69162 71765 68090 20293 72599 22642 28146 72544 624153 66446 606496 625328 100037258 51788 11518 15077 74322 16905 109075 15191 69276 319149 11910 54616 53421 100043039 70640 22393 227753 16600 15183 15530 22139 17246 19211 18519 27096 235416 27392 171212 11842 241159 67542 11839 54644 20357 19703 235504 75540 11840 228607 17829 100689 15510 233744 50798 102115 77371 216799 59288 170707 20448 11881 66901 74112 109785 245828 11883 11555 70527 75826 66661 330817 380959 240119 217337 225896 22632 78928 20687 55989 107652 21420 22658 21419 11844 234730 67134 17156 68947 11835 70349 77125 56207 12847 17063 210004 18636 56174 30806 74498 20446 23794 56358 110616 12418 269328 245847 668145 67902 67857 108105 232984 67228 63828 213575 50935 24060 328370 108123 30951 108124 22217 233875 217069 217364 20451 213827 21802 19089 11843 22591 12794 436004 224836 80286 217664 17309 99011 225280 17127 105638 207958 234663 70361 20014 22428 56316 217615 14462 67511 67569 102339 71586 317717 56469 108138 66341 76630 108150 407786 83563 68137 69740 69641 230073 14376 545486 13619 56612 22334 238463 78754 73710 319651 100039649 22143 276846 67199 56703 22151 54383 18637 233824 22147 54161 67951 19025 22327 13628 21974 22146 66251 53857 67711 109054 140474 22152 269523 235323 110417 77038 100756 19324 21973 22335 21969 18701 110962 97440 56447 14463 227697 56737 108760 20703 67292 14426 73732 18700 327799 230815 19358 59040 19359 19357 52036 246103 57377 107260 68837 76983 56456 66682 16319 14976 654821 99683 18010 360216 54342 70020 170822 23956 68501 239436 67422 224139 66500 99412 76308 89867 170711 110119 108148 22190 14425 14423 240322 26409 13032 667035 338366 69048 19128 19123 72265 276770 210148 230801 17158 224116 19671 353328 192156 76800 22034 212996 66513 50877 20848 97484 319162 57295 56208 11733 229615 11735 55949 68563 71954 329777 21951 216131 54613 19365 67909 243819 269959 15929 12836 12416 54601 67872 59042 57170 18002 66656 56324 105522 14275 218214 67160 12151 68273 11429 252870 208624 12974 20445 13426 69064 208211 15387 14479 67556 12764 56459 68149 66890 100042773 235606 22225 13138 13135 116905 333883 67728 67311 193813 75302 67075 207596 108155 320438 56386 57370 56375 53418 22242 56336 331026 69080 66789 14061 20390 226418 20389 68142 20388 84585 20387 20333 11799 54128 12578 29858 271127 74008 18854 208936 17425 231050 71956 67231 22230 216185 14731 20844 210417 22223 50933 227327 107338 27401 381903 66647 67091 54198 330119 240913 50868 110350 59048 12091 15161 330267 57783 116870 433931 17131 71665 108153 328572 13200 15251 215474 77739 56505 207839 14595 107895 21826 21825 216853 17308 241391 227195 72297 69608 208691 109359 100043429 226026 94192 21803 214895 21813 21812 17869 16494 76332 59005 58911 59007 59025 14466 66632 11789 17125 17128 217057 17126 19763 52014 77041 243369 12005 17342 77794 225849 16430 66124 15239 14068 14058 18035 14071 16151 14069 74996 242362 230145 338337 271970 16834 109154 319169 67727 14067 94181 218210 67819 66679 20334 18226 80294 235134 69912 241915 621893 56233 228790 227720 218811 54563 76510 223921 12793 103468 216825 70699 272411 56249 241062 72787 20356 72084 319189 56395 235441 231727 56436 14584 224697 109275 67475 269181 11891 269113 68031 231042 26938 234865 17155 11606 69736 12638 19069 15381 107939 101206 14465 319176 55981 93721 30937 170762 14232 20531 18970 68097 11545 319173 12876 52276 18549 108645 16574 54160 50527 50797 216197 66119 24110 70546 223696 414084 12945 239337 20505 11551 13481 224792 50873 56041 27410 100043869 74091 11553 13480 59015 20877 227699 74270 223838 18141 71472 327942 16541 16795 13036 67561 445007 14799 56418 11890 108989 229595 19386 66548 20447 66226 69482 11889 71805 110379 67891 103963 100042986 14456 100042740 68350 24128 621100 15267 100043295 102580 67097 103534 13629 13478 100043000 53625 625646 223870 67281 69714 633683 227648 666899 26887 16785 98388 100039316 14537 267019 66913 100040970 64138 20454 60409 53333 71599 28185 12330 22333 14534 66169 319163 320213 381694 19941 13982 382492 319168 24067 20055 72077 66384 19951 66889 20813 100042670 228368 27058 22122 68193 319167 18976 665189 333424 668182 24061 19921 225742 20044 22284 668144 22196 100043423 71685 100043893 20439 670832 235130 100043876 20843 629957 67665 71883 225058 237360 22121 12006 75617 104416 667279 72978 76846 279028 27050 228366 100043184 233733 19934 50995 100040331 217734 100043391 18793 319195 54399 68172 241230 241053 56229 100043209 100042343 20102 20449 67941 20442 27207 20443 668668 236733 20103 226866 672214 228812 622534 17957 20085 20440 20084 20444 FORMATION OF EDITOSOMES BY ADAR PROTEINS%REACTOME%R-HSA-77042.1 Formation of editosomes by ADAR proteins 110532 56417 SIGNALING BY NOTCH4%REACTOME%R-HSA-1980150.2 Signaling by NOTCH4 19165 59287 54485 11487 100039623 13388 16450 100042305 208117 16449 18132 EARLY PHASE OF HIV LIFE CYCLE%REACTOME DATABASE ID RELEASE 57%162594 Early Phase of HIV Life Cycle 268373 12767 12774 15361 16881 14156 12504 319583 108138 22596 14375 101739 16646 23825 CYSTEINE FORMATION FROM HOMOCYSTEINE%REACTOME%R-HSA-1614603.1 Cysteine formation from homocysteine 107869 12411 CDO IN MYOGENESIS%REACTOME%R-HSA-375170.1 CDO in myogenesis 57810 17260 21406 17928 17261 21413 29857 12555 17927 17877 19094 12558 18209 17259 17258 12386 18007 12561 12175 17878 70834 21423 12385 26416 12387 11350 26399 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER%REACTOME DATABASE ID RELEASE 57%3304351 Signaling by TGF-beta Receptor Complex in Cancer 17127 17128 14225 17126 21803 21813 21812 HDR THROUGH HOMOLOGOUS RECOMBINATION (HRR)%REACTOME DATABASE ID RELEASE 57%5685942 HDR through Homologous Recombination (HRR) 18973 19687 17535 69263 67967 12021 19718 18972 18538 19891 69745 68240 18971 74335 12189 11920 231724 237911 327762 27015 80905 21975 19355 19367 59001 72151 106344 66979 18974 22427 68275 19356 12144 235559 22190 667035 12190 52864 233826 268465 19364 19360 235610 114714 57434 224008 209334 81601 19362 71711 19363 225182 269400 19361 27354 15574 12649 26909 GABA B RECEPTOR ACTIVATION%REACTOME DATABASE ID RELEASE 57%977444 GABA B receptor activation 16524 16515 224129 16522 16513 11513 11512 16520 11515 11514 104110 16518 16521 14706 16516 14678 14677 14679 14688 14708 14693 14709 14699 14700 14701 210044 432530 14695 104111 16517 14704 242425 14702 14710 16519 54393 242851 14680 NEF-MEDIATES DOWN MODULATION OF CELL SURFACE RECEPTORS BY RECRUITING THEM TO CLATHRIN ADAPTERS%REACTOME%R-HSA-164938.1 Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters 108012 12504 11768 108664 11772 11769 232910 16818 252903 11773 11840 15007 11767 11771 71770 107975 12010 12526 12487 11765 11764 EGFR DOWNREGULATION%REACTOME DATABASE ID RELEASE 57%182971 EGFR downregulation 58194 13859 19272 54126 13858 22190 13854 13645 24063 667035 12402 20404 24064 20844 15239 56324 13649 TYPE II NA+ PI COTRANSPORTERS%REACTOME DATABASE ID RELEASE 57%427589 Type II Na+ Pi cotransporters 20531 142681 20505 XENOBIOTICS%REACTOME DATABASE ID RELEASE 57%211981 Xenobiotics 56448 622127 545817 13107 13087 13088 74134 13113 13114 72082 13106 13110 13077 107141 13076 72303 KERATAN SULFATE KERATIN METABOLISM%REACTOME%R-HSA-1638074.1 Keratan sulfate keratin metabolism 53625 70484 75612 14595 76969 72297 56386 57370 231727 56375 53418 56336 14264 18295 27047 116847 16545 17022 54613 54371 227327 108902 15212 15211 20442 20443 12091 56773 20444 STEROID HORMONES%REACTOME%R-HSA-209943.1 Steroid hormones 114664 15483 56348 15486 13081 78925 244209 15485 94224 13115 15484 14187 14725 65969 14149 14473 13070 170460 66065 13075 18976 100042622 20845 68165 170459 11677 14148 110115 13074 19141 15487 15492 15497 12640 13072 16866 13079 57357 SIGNALING BY FGFR4%REACTOME%R-HSA-5654743.2 Signaling by FGFR4 17346 12402 24064 56438 26395 67603 319520 235584 26403 16416 12223 54519 100042150 21894 11600 19060 19186 19188 327826 17169 194231 109905 14161 226525 57296 67151 215449 18710 19185 66998 53380 14172 17967 15461 17463 83409 69077 29875 12912 26417 26413 12323 108058 12322 18015 59029 19197 19417 19184 19179 22190 20422 171463 14573 667035 19182 16590 240057 19181 64654 231474 14173 80903 14164 23997 66997 18039 218397 110135 14585 14178 80857 228769 14180 70247 67089 14586 14587 14175 21762 14177 23996 20416 11876 14165 26554 18596 109880 16399 54153 18708 15200 640703 18706 18673 12325 16818 16706 69601 83379 22371 73902 233046 114716 12981 19415 63953 14174 12982 19252 16653 12984 240672 13537 12988 67836 16186 13385 14588 211323 16184 11836 18188 20740 20739 13645 16185 16452 216869 109689 18176 72399 70686 114715 240168 14268 66413 211255 18183 14083 16451 19192 16453 26445 19166 18218 12576 14812 76089 26444 26446 14811 26443 14813 19414 80297 14814 12575 74769 16183 20742 18707 18709 20741 21687 20743 16367 13866 14810 16192 26396 14360 16191 216148 114713 14186 19418 22123 20662 19052 14170 19053 19262 73699 640524 16913 75590 19175 19177 51792 19713 19170 22330 99571 13874 103554 16912 54401 83961 56637 16188 19173 19172 21770 107971 26932 100986 226849 18611 23980 20418 26931 320484 225849 384783 12675 245684 67112 110157 19167 26441 19419 11472 19171 545987 13649 70727 18595 26442 26440 101809 18591 18750 19088 16334 76850 18753 18754 236511 19247 16337 75778 15370 18752 104110 229709 12519 12524 606496 244650 18573 12015 56717 22084 224129 77647 11513 11512 239528 11515 11514 12371 98432 117150 18803 56458 56484 213988 12326 11652 18717 12478 11651 15937 16440 78757 228775 12487 110355 18747 18574 16438 18749 217351 210044 18575 432530 233833 23797 104111 67605 18720 17246 56716 18719 214150 108083 19087 19085 18607 19084 14388 22324 19211 227743 18718 109270 17454 16439 58988 REACTIONS SPECIFIC TO THE COMPLEX N-GLYCAN SYNTHESIS PATHWAY%REACTOME DATABASE ID RELEASE 57%975578 Reactions specific to the complex N-glycan synthesis pathway 217664 53618 17158 68947 71665 12640 16866 98388 CD28 CO-STIMULATION%REACTOME DATABASE ID RELEASE 57%389356 CD28 co-stimulation 53859 56717 19353 75778 12519 12524 11652 18710 11651 22612 18479 78757 228775 12487 17096 18708 23797 17444 18706 16818 56716 18709 18607 18481 22324 14360 227743 109270 26410 224105 ACTIVATION OF BIM AND TRANSLOCATION TO MITOCHONDRIA%REACTOME DATABASE ID RELEASE 57%111446 Activation of BIM and translocation to mitochondria 56455 26419 12125 ACTIVATION OF NA-PERMEABLE KAINATE RECEPTORS%REACTOME%R-HSA-451307.1 Activation of Na-permeable Kainate Receptors 14805 14806 PEPTIDE HORMONE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 57%209952 Peptide hormone biosynthesis 14308 16324 16325 16326 12640 18548 16866 16322 16323 18976 22094 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION%REACTOME%R-HSA-109688.1 Cleavage of Growing Transcript in the Termination Region 193116 107829 110809 225027 60365 331401 66511 68278 67337 228410 68219 19826 67996 73666 20382 53817 51786 71713 70579 116748 66231 69823 233073 73826 69207 108014 386612 72290 17149 94230 100040029 192160 625193 67332 20638 225160 20492 68092 66441 54196 54188 433702 54451 384091 108062 64340 192170 66899 622469 51796 243963 21681 18789 666609 20383 68134 269061 98985 FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION%REACTOME DATABASE ID RELEASE 57%434316 Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion 14682 18796 14675 18795 14676 14672 18797 233081 BREAKDOWN OF THE NUCLEAR LAMINA%REACTOME%R-HSA-352238.1 Breakdown of the nuclear lamina 12368 16906 GP1B-IX-V ACTIVATION SIGNALLING%REACTOME%R-HSA-430116.1 GP1b-IX-V activation signalling 22371 192176 110157 18708 22631 54368 14723 14729 14724 PLATELET SENSITIZATION BY LDL%REACTOME%R-HSA-432142.1 Platelet sensitization by LDL 15170 26416 18783 21770 19247 26932 14191 226849 26931 225849 19052 19053 73699 18613 51792 238055 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION%REACTOME%R-HSA-438066.1 Unblocking of NMDA receptor, glutamate binding and activation 12323 13385 53623 14812 108058 12322 14811 14813 100986 12325 14814 18039 11472 14810 14799 14802 14800 CLEC7A (DECTIN-1) INDUCES NFAT ACTIVATION%REACTOME DATABASE ID RELEASE 57%5607763 CLEC7A (Dectin-1) induces NFAT activation 18018 16438 18019 19058 19056 19055 16440 640703 229709 18021 16439 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM%REACTOME DATABASE ID RELEASE 57%1793185 Chondroitin sulfate dermatan sulfate metabolism 14734 59031 212898 13003 109685 53374 78752 12032 20971 103978 20969 11603 319901 15931 76898 72727 11881 71951 15932 217119 23888 218271 15530 233781 14735 338362 280645 20970 78923 15212 121021 15529 74241 117592 269941 15211 58250 13004 12111 15586 29873 72136 14733 60322 77590 13179 234356 71797 PROSTANOID LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 57%391908 Prostanoid ligand receptors 19216 19218 14764 21390 19220 19214 19219 19217 19222 PASSIVE TRANSPORT BY AQUAPORINS%REACTOME%R-HSA-432047.1 Passive transport by Aquaporins 11833 11831 11832 17339 11830 11829 11826 66333 64008 11827 11828 208760 PKMTS METHYLATE HISTONE LYSINES%REACTOME%R-HSA-3214841.2 PKMTs methylate histone lysines 14056 52615 13626 110147 19646 67956 107823 140858 73251 381022 234135 75410 52690 213389 66310 54343 64707 20937 69726 239122 18193 77683 84505 214162 235626 231051 213464 208043 233904 208266 23808 14013 70673 226830 11569 15077 319149 245688 CASPASE ACTIVATION VIA EXTRINSIC APOPTOTIC SIGNALIG PATHWAY%REACTOME DATABASE ID RELEASE 57%5357769 Caspase activation via extrinsic apoptotic signalig pathway 22030 12367 14082 21933 14102 14103 22035 12370 12371 71609 19766 94275 21898 106759 142980 12475 225471 13176 13143 17087 72993 13144 107448 69635 107449 FRS-MEDIATED FGFR3 SIGNALING%REACTOME%R-HSA-5654706.1 FRS-mediated FGFR3 signaling 56438 26395 67603 319520 235584 26403 16416 12223 54519 100042150 21894 11600 19060 19186 19188 327826 17169 194231 109905 14161 226525 57296 67151 215449 19185 66998 53380 14172 17967 15461 17463 83409 69077 29875 26417 26413 12323 108058 12322 18015 59029 19197 19417 19184 19179 22190 20422 171463 14573 667035 19182 16590 240057 19181 231474 64654 80903 14173 23997 14164 66997 18039 218397 110135 14585 14178 80857 228769 14180 70247 67089 14586 14587 14175 21762 14177 23996 20416 11876 14165 26554 18596 109880 16399 54153 15200 640703 18673 12325 16706 69601 83379 22371 73902 233046 114716 12981 19415 63953 14174 12982 19252 16653 12984 240672 13537 12988 67836 16186 13385 14588 211323 16184 11836 18188 20740 20739 13645 16185 16452 216869 109689 18176 72399 70686 114715 240168 14268 66413 211255 18183 14083 16451 19192 16453 26445 19166 18218 14812 76089 26444 26446 14811 26443 14813 19414 80297 14814 16183 20742 20741 21687 20743 16367 13866 14810 16192 26396 14360 16191 216148 114713 14186 19418 22123 20662 19052 14170 19053 19262 73699 640524 16913 75590 19175 19177 51792 19713 19170 22330 99571 13874 103554 16912 54401 83961 16188 19173 19172 21770 26932 107971 226849 100986 18611 23980 26931 20418 225849 320484 384783 245684 67112 110157 19167 26441 19419 11472 19171 545987 13649 70727 18595 26442 26440 101809 18591 19247 PLATELET ACTIVATION, SIGNALING AND AGGREGATION%REACTOME DATABASE ID RELEASE 57%76002 Platelet activation, signaling and aggregation 16822 14706 14696 14678 14677 14679 70839 14688 14708 22145 14693 18441 14709 14697 17096 57257 20909 12631 22325 242851 16797 14726 243816 56760 19353 106722 12527 11674 54368 14723 14729 12491 14724 223864 22138 11820 56508 14699 66066 14700 14701 14695 18755 14704 14702 331374 56077 14710 14065 64337 66082 320127 11537 380921 110524 12759 104418 17480 13139 14062 14673 110197 76192 231871 21832 269060 11552 14064 217480 66866 16416 20912 109232 20255 54519 74840 14828 20344 21767 19073 21894 80884 13601 108101 16784 21346 56541 117586 67059 109905 268936 20716 22388 14161 80718 94175 26968 11747 215449 11625 18710 227612 19039 71946 13041 19395 667310 240334 68038 18407 16427 12512 218454 104009 18816 53612 20703 12321 20911 72017 18783 22341 67072 22631 16426 235505 26417 22340 57349 26413 56744 11818 54216 21922 60595 27999 56055 12258 385643 71660 68117 14205 56193 70945 104709 19128 30955 110135 22041 320207 14682 20416 192176 14675 21390 14676 14672 14127 14674 14389 16399 18708 18761 18706 640703 16818 22371 12981 12982 12984 18787 12988 16186 16184 23945 20963 13645 16185 16452 216869 109689 14268 11806 14083 16451 16453 14061 15170 21857 20692 74769 16183 239273 18707 18709 232345 16192 14360 16191 268373 21808 12927 11848 22339 21825 20662 22065 21803 21809 22330 99571 26416 16188 215789 11804 22068 27359 223601 12331 67988 21859 20363 75396 74145 110157 14069 19419 11472 18613 14067 18591 18750 19156 18753 18754 19247 26946 18752 16000 18762 18751 16002 15234 11551 11553 320202 14456 18643 234779 11652 56212 12928 11651 19354 16440 11852 16438 109711 23797 18607 18815 22324 11657 19246 16439 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS%REACTOME DATABASE ID RELEASE 57%2122948 Activated NOTCH1 Transmits Signal to the Nucleus 11487 14357 227325 11491 13386 74198 22190 18011 667035 216869 109689 59287 54485 13388 207521 16450 12805 16449 16396 225164 240055 208117 76580 19165 100039623 100042305 18222 18128 POLO-LIKE KINASE MEDIATED EVENTS%REACTOME%R-HSA-156711.1 Polo-like kinase mediated events 19646 328572 108000 75660 22390 17865 18817 14235 268930 629959 12532 12530 231506 12442 72568 SYNTHESIS OF WYBUTOSINE AT G37 OF TRNA(PHE)%REACTOME DATABASE ID RELEASE 57%6782861 Synthesis of wybutosine at G37 of tRNA(Phe) 209584 76357 68260 68736 329504 100929 METABOLISM OF POLYAMINES%REACTOME DATABASE ID RELEASE 57%351202 Metabolism of polyamines 11846 20810 67870 212503 56369 20229 18416 67873 671878 19186 109900 19188 83885 67824 227231 104923 11898 57296 67151 18408 11847 66413 66902 19185 217214 66998 53380 243616 14411 19192 26445 17463 19166 69077 240332 26444 26446 26443 22123 59029 19184 19179 20422 19182 19181 23997 66997 75986 16913 12709 242669 228769 76722 14718 19175 70247 67092 19177 67089 102857 14431 19170 12716 21762 12715 23996 18263 53814 103554 16912 19173 19172 73902 19167 26441 19171 26442 26440 18104 18247 18245 54375 ALTERNATIVE COMPLEMENT ACTIVATION%REACTOME DATABASE ID RELEASE 57%173736 Alternative complement activation 12266 11537 14962 16904 FGFR1C LIGAND BINDING AND ACTIVATION%REACTOME%R-HSA-190373.3 FGFR1c ligand binding and activation 64654 14173 14164 80857 14180 14175 14177 ENTRY OF INFLUENZA VIRION INTO HOST CELL VIA ENDOCYTOSIS%REACTOME DATABASE ID RELEASE 57%168275 Entry of Influenza Virion into Host Cell via Endocytosis 67300 12757 SPERM MOTILITY AND TAXES%REACTOME DATABASE ID RELEASE 57%1300642 Sperm Motility And Taxes 329954 106757 76856 16532 271036 320225 74096 212670 225865 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10%REACTOME DATABASE ID RELEASE 57%933543 NF-kB activation through FADD RIP-1 pathway mediated by caspase-8 and -10 71586 16151 217069 16150 14082 71956 12370 12675 230073 19766 228607 NICOTINATE METABOLISM%REACTOME%R-HSA-196807.1 Nicotinate metabolism 19223 59027 246703 67375 78914 66454 19225 67993 226518 13124 192185 223646 74080 ACYL CHAIN REMODELLING OF PG%REACTOME%R-HSA-1482925.1 Acyl chain remodelling of PG 26971 18784 78390 18783 66586 226856 18779 210992 18782 66350 18778 271844 237625 99010 26970 26565 DEFECTIVE CHST3 CAUSES SEDCJD%REACTOME DATABASE ID RELEASE 57%3595172 Defective CHST3 causes SEDCJD 121021 13003 12032 13004 12111 29873 13179 ACTIVATION OF SMO%REACTOME DATABASE ID RELEASE 57%5635838 Activation of SMO 16568 57810 93687 13363 20423 16147 216869 109689 74239 117606 19206 104346 319757 230500 68525 14451 110355 59056 TACHYKININ RECEPTORS BIND TACHYKININS%REACTOME DATABASE ID RELEASE 57%380095 Tachykinin receptors bind tachykinins 21333 21334 21336 21337 21338 LGI-ADAM INTERACTIONS%REACTOME DATABASE ID RELEASE 57%5682910 LGI-ADAM interactions 11488 13385 246316 56839 213469 23792 81905 243914 54377 11496 56216 20907 54376 12300 G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA%REACTOME DATABASE ID RELEASE 57%392451 G beta:gamma signalling through PI3Kgamma 16186 104709 16184 11848 16185 16452 30955 14706 11652 14696 18710 11651 14688 16451 14708 16453 14693 14709 320207 14697 14699 20416 66066 14700 14701 14389 16188 18708 23797 14695 18706 14704 14702 74769 16183 14710 64337 18707 18709 18607 12981 16192 12982 16191 12984 REGULATION OF FZD BY UBIQUITINATION%REACTOME DATABASE ID RELEASE 57%4641263 Regulation of FZD by ubiquitination 14370 14368 207742 14367 22190 329252 239405 228770 667035 107515 14160 72780 22416 407821 192199 16973 84092 14366 16974 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 57%69580 p53-Dependent G1 S DNA damage checkpoint 59092 19186 19188 57296 67151 66413 17248 26374 19185 11920 66998 53380 19192 26445 17463 19166 69077 12576 26444 12448 26446 22059 26443 12575 12566 29813 22123 59029 19184 19179 22190 20422 667035 19182 12427 19181 23997 66997 16913 12447 228769 70247 19175 67089 19177 19170 21762 23996 103554 16912 19173 19172 17246 73902 50883 19167 26441 19171 26442 26440 12428 G2 M DNA REPLICATION CHECKPOINT%REACTOME%R-HSA-69478.1 G2 M DNA replication checkpoint 12534 22390 12442 268930 NFG AND PRONGF BINDS TO P75NTR%REACTOME DATABASE ID RELEASE 57%205017 NFG and proNGF binds to p75NTR 18049 18053 PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 57%391251 Protein folding 108077 66411 99371 55946 19739 30839 56327 66887 14706 24012 14678 14696 14677 14679 213980 14688 30838 22145 14708 14693 14709 30050 14697 12466 12467 12469 242960 67466 50754 12465 50789 21454 12462 12461 12464 16553 12468 13000 67134 100039026 70430 242851 108903 71833 106052 50762 21371 22153 72726 27055 14447 227613 22142 216853 12447 14699 66066 14700 14701 14466 14695 14704 14702 14710 64337 545486 56612 238463 73710 22143 67199 22151 18637 22147 67951 22327 22146 53857 109054 22152 20698 12448 22059 14976 24128 11461 13001 20848 15183 50779 68628 50782 14681 236733 14685 14686 14687 TRANSPORT OF NUCLEOTIDE SUGARS%REACTOME%R-HSA-727802.1 Transport of nucleotide sugars 58246 229782 70484 73836 22232 228368 242585 24060 108652 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT%REACTOME%R-HSA-1428517.1 The citric acid (TCA) cycle and respiratory electron transport 66706 229211 670717 12868 68202 17992 17710 66152 17711 17709 68472 75406 70207 69702 22272 20463 231430 70316 76916 52892 17708 100040287 69487 67273 76826 66495 17991 12861 12857 22273 54405 17722 66091 100042918 104130 110323 66841 68198 110826 66694 110842 20930 73694 230075 76947 67003 100041785 67530 68493 26940 17719 66142 66379 12858 17718 72416 17717 17716 239760 66359 225887 66108 17721 66416 68375 66916 67130 78330 75597 67184 66414 623286 66218 67264 68342 100042503 226646 595136 72900 227197 68197 66377 66046 17995 17993 624814 66272 66445 69802 19015 74011 55951 70456 381511 217666 109801 235339 22227 98314 20523 18604 22228 20181 27273 22229 18597 228026 68263 236900 76187 382051 16828 27402 106557 16833 16832 319518 80879 269951 57274 15929 20917 20501 57423 11957 11946 66945 12215 11947 14194 432676 18293 228033 56451 17705 66052 66043 170718 68055 78920 11949 11429 100039108 227112 18115 100041835 12974 11950 13382 17448 11958 20916 66925 67834 67680 FICOLINS BIND TO REPETITIVE CARBOHYDRATE STRUCTURES ON THE TARGET CELL SURFACE%REACTOME DATABASE ID RELEASE 57%2855086 Ficolins bind to repetitive carbohydrate structures on the target cell surface 14134 REV-MEDIATED NUCLEAR EXPORT OF HIV RNA%REACTOME DATABASE ID RELEASE 57%165054 Rev-mediated nuclear export of HIV RNA 218210 66679 18226 69912 227720 54563 19385 223921 103468 70699 72787 100088 269113 231042 234865 69736 19069 107939 170762 103573 59015 227699 18141 445007 108989 19386 19384 69482 71805 TRANSLOCATION OF ZAP-70 TO IMMUNOLOGICAL SYNAPSE%REACTOME%R-HSA-202430.3 Translocation of ZAP-70 to Immunological synapse 12500 12502 14960 12501 12504 14968 22637 19260 16818 14969 CD28 DEPENDENT PI3K AKT SIGNALING%REACTOME DATABASE ID RELEASE 57%389357 CD28 dependent PI3K Akt signaling 53859 56717 23797 18708 18706 75778 56716 16818 12519 12524 18709 18607 11652 18710 11651 14360 227743 78757 228775 12487 26410 109270 SMAD4 MH2 DOMAIN MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 57%3311021 SMAD4 MH2 Domain Mutants in Cancer 17127 17128 17126 DNA DOUBLE STRAND BREAK RESPONSE%REACTOME DATABASE ID RELEASE 57%5693606 DNA Double Strand Break Response 100039592 17535 12021 319181 19060 70620 15204 70681 240087 12189 11920 93762 382522 70238 210766 27223 22059 11350 20184 59004 319183 14048 14049 22190 193796 319182 319178 230674 319186 667035 14051 14050 319190 11785 107823 26419 93765 22196 19360 107976 319152 104416 68251 81601 22385 27354 50883 319188 15270 78303 RETINOID METABOLISM AND TRANSPORT%REACTOME DATABASE ID RELEASE 57%975634 Retinoid metabolism and transport 19659 109791 63857 14734 65107 68453 79235 67861 55938 20971 103978 20969 19662 83702 19660 11603 239393 170752 14725 11806 11808 11813 71951 238055 23888 11807 17252 15530 14735 22139 16971 69060 20970 15529 16956 77337 11814 105349 14733 665270 16835 11816 NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME%R-HSA-181430.1 Norepinephrine Neurotransmitter Release Cycle 12889 22318 327814 68507 20517 19339 214084 22249 20518 17161 233977 20907 20614 20979 PROTON-COUPLED NEUTRAL AMINO ACID TRANSPORTERS%REACTOME DATABASE ID RELEASE 57%428559 Proton-coupled neutral amino acid transporters 246049 215335 TRYPTOPHAN CATABOLISM%REACTOME%R-HSA-71240.1 Tryptophan catabolism 98256 70266 209176 107766 15930 70789 56720 23923 71562 266645 229905 MITOCHONDRIAL TRANSLATION ELONGATION%REACTOME%R-HSA-5389840.1 Mitochondrial translation elongation 56284 56282 24030 14548 67707 94061 69956 94067 107734 68611 67681 28030 74600 78523 66419 60441 56280 121022 69527 66407 77721 66230 68537 67994 28028 64655 66242 68565 69163 67840 68735 27398 65111 216767 67308 66047 52443 66163 64657 99045 118451 64656 79044 59054 27397 66493 67036 218506 94063 353242 64660 68499 66973 75398 107732 66223 27393 68836 67212 18120 66121 50529 66258 57312 623346 232536 102060 94062 64659 107733 68463 622268 66845 66399 66077 94065 66292 233870 100042811 66448 18100 94066 64658 68572 100040519 CELLULAR RESPONSE TO HEAT STRESS%REACTOME DATABASE ID RELEASE 57%3371556 Cellular response to heat stress 218210 66679 18226 69912 14828 227720 54563 223921 103468 19891 70699 68240 72787 269523 11920 269113 231042 234865 69736 19069 107939 12017 110920 170762 17164 68196 193740 15481 81489 15185 12955 26417 93759 15482 15512 26413 100043508 14228 74370 15519 59015 15499 67669 227699 80888 56354 15505 18141 22791 66538 18415 70369 445007 15526 50497 68275 213539 73442 108989 219158 19386 72630 29810 15525 69482 70356 71805 23950 12323 108058 12322 56717 12914 328572 15516 22627 67384 56637 67605 12325 56716 ERK MAPK TARGETS%REACTOME DATABASE ID RELEASE 57%198753 ERK MAPK targets 110651 26416 17260 13712 21770 72349 20111 26417 26413 23939 20112 67603 19052 19053 319520 73699 73086 19094 17258 51792 235584 VOLTAGE GATED POTASSIUM CHANNELS%REACTOME%R-HSA-1296072.1 Voltage gated Potassium channels 241794 67498 238271 16510 192775 16499 16504 382571 16490 16492 240595 16491 226922 225030 66733 16485 98741 380728 16539 16512 16497 16538 99738 242151 16500 16502 170738 16493 16494 16498 268345 16495 240444 60613 238076 110862 16536 16508 211468 16511 56543 16506 16535 CS DS DEGRADATION%REACTOME DATABASE ID RELEASE 57%2024101 CS DS degradation 13003 109685 12032 15931 121021 15212 15211 13004 12111 11881 29873 15586 15932 13179 APC TRUNCATION MUTANTS ARE NOT K63 POLYUBIQUITINATED%REACTOME DATABASE ID RELEASE 57%5467333 APC truncation mutants are not K63 polyubiquitinated 11789 RNA POLYMERASE II HIV PROMOTER ESCAPE%REACTOME%R-HSA-167162.1 RNA Polymerase II HIV Promoter Escape 67710 68776 66464 21374 17749 66420 245841 235459 209361 66467 20021 69241 99730 319944 24074 108143 229906 83602 270627 14884 66671 228980 68153 74197 23894 12572 226182 216185 17420 13871 13872 209357 69833 14885 68705 72504 20022 69920 21343 231329 98053 407786 100043714 20020 ACTIVATION OF CAMK IV%REACTOME DATABASE ID RELEASE 57%442745 Activation of CaMK IV 12326 640703 TRANSPORT OF NUCLEOSIDES AND FREE PURINE AND PYRIMIDINE BASES ACROSS THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 57%83936 Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane 71279 114304 63959 243328 269346 13340 434203 PROPIONYL-COA CATABOLISM%REACTOME DATABASE ID RELEASE 57%71032 Propionyl-CoA catabolism 17850 110821 66904 109136 73724 RHO GTPASES ACTIVATE FORMINS%REACTOME DATABASE ID RELEASE 57%5663220 RHO GTPases Activate Formins 13543 18817 26951 67629 69928 11799 236930 68014 18472 208628 57294 13589 52696 76707 67733 83815 102920 76464 66570 83431 108911 76499 18221 12617 19047 75786 26886 66934 19353 14270 11848 19052 19053 73699 51792 73804 21770 26932 226849 26931 103573 225849 229841 69912 16563 12237 103468 56150 234865 69736 11854 20807 52276 56419 20877 59015 223701 16319 445007 19386 110379 320394 226747 66442 12615 72155 13367 108000 18643 11461 12236 18645 60411 625534 232987 66468 67052 52504 67139 70385 11852 71876 73470 71409 70454 11465 22379 17120 208846 11853 57778 13542 14026 13544 228421 320271 244495 107995 381318 66336 67037 216965 72415 56430 16412 66977 12235 PHASE 4 - RESTING MEMBRANE POTENTIAL%REACTOME%R-HSA-5576886.1 Phase 4 - resting membrane potential 223604 16515 210741 16520 72258 211480 217826 16528 16526 16527 16518 16529 52150 241769 16530 332396 16525 74571 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1%REACTOME%R-HSA-418592.2 ADP signalling through P2Y purinoceptor 1 14699 14682 66066 14675 14700 26416 14701 14676 14672 18783 14695 14704 14702 14710 64337 14706 14696 14688 14708 14693 18441 14709 14697 REELIN SIGNALLING PATHWAY%REACTOME DATABASE ID RELEASE 57%8866376 Reelin signalling pathway 13131 58194 14360 22359 19699 FGFR4 LIGAND BINDING AND ACTIVATION%REACTOME%R-HSA-190322.1 FGFR4 ligand binding and activation 64654 14170 80903 14173 14164 14172 80857 14180 14186 14175 14177 83379 CA2+ PATHWAY%REACTOME DATABASE ID RELEASE 57%4086398 Ca2+ pathway 18750 18796 18795 76850 14365 14368 14367 236511 22418 57265 14706 14696 14688 14708 14693 18797 14709 14697 18018 18587 225600 18588 21416 14366 12322 239528 26409 19056 213988 19055 22411 18099 19092 16440 14699 16438 66066 14700 217351 14701 233833 14695 21414 640703 16842 12387 21415 14704 19091 14702 14710 214150 64337 19058 14681 14686 17454 16439 NON-CODING RNA METABOLISM%REACTOME DATABASE ID RELEASE 57%194441 Non-coding RNA Metabolism 218210 66679 18226 69912 227720 54563 223921 103468 70699 72787 269113 231042 234865 69736 19069 107939 170762 56698 621705 67332 20638 20595 70465 66603 66069 59015 20641 227699 68092 27374 216766 18141 384091 433702 107686 53975 12729 445007 108989 19386 276919 666609 69731 69482 71805 TRANSLATION INITIATION COMPLEX FORMATION%REACTOME%R-HSA-72649.1 Translation initiation complex formation 13665 20115 57294 667739 27370 100038875 208643 66481 100040298 18458 67097 66235 633683 667035 16785 55944 13669 100039316 27979 267019 68135 66085 26905 22384 53356 56347 13684 67204 223691 382492 13682 20055 73830 16341 100042807 13681 54709 75705 98221 20044 668144 670832 629957 225058 75617 667279 76846 27050 20102 67941 27207 668668 20103 20085 20084 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX%REACTOME%R-HSA-201722.4 Formation of the beta-catenin:TCF transactivating complex 17283 319181 232440 382522 319176 433759 624153 625328 51788 15077 21416 100683 319149 12914 15267 319183 328572 21888 319182 56505 319178 21885 319186 21886 319190 21752 381022 319168 214498 17869 20586 235497 319167 80288 213464 23808 21414 16842 12006 319152 12387 21415 81601 77578 68911 21887 72135 319188 15270 319169 78303 FGFR4 MUTANT RECEPTOR ACTIVATION%REACTOME DATABASE ID RELEASE 57%1839128 FGFR4 mutant receptor activation 14186 DEGRADATION OF DVL%REACTOME DATABASE ID RELEASE 57%4641258 Degradation of DVL 13543 19186 19188 57296 67151 66413 19185 66998 53380 19192 17463 26445 19166 69077 26444 26446 26443 56438 22123 59029 19184 19179 22190 20422 667035 19182 19181 23997 66997 16913 228769 70247 19175 67089 19177 19170 21762 23996 240756 94253 103554 59036 16912 26554 19173 19172 13542 13544 73902 19167 26441 19171 26442 26440 NICOTINAMIDE SALVAGING%REACTOME DATABASE ID RELEASE 57%197264 Nicotinamide salvaging 59027 246703 19223 19225 67993 13124 223646 ATP SENSITIVE POTASSIUM CHANNELS%REACTOME DATABASE ID RELEASE 57%1296025 ATP sensitive Potassium channels 20928 16523 16514 20927 PLATELET HOMEOSTASIS%REACTOME DATABASE ID RELEASE 57%418346 Platelet homeostasis 19247 60596 26946 234889 54195 18436 20866 231602 14706 94045 109552 14696 228139 18440 18438 109305 14688 14708 14693 14709 238055 11941 14697 242202 15170 207728 23984 18783 14191 269717 18127 110891 18439 18573 110893 17540 19052 58802 19053 16531 73699 18125 22065 241489 18126 19092 16440 54611 20541 72413 51792 18585 18576 435726 18574 16533 14699 16438 66066 14700 26416 14701 21770 26932 22068 14695 226849 640703 14704 14702 26931 225849 14710 64337 11938 53313 11937 18613 381290 320707 67972 19222 16439 L1CAM INTERACTIONS%REACTOME DATABASE ID RELEASE 57%373760 L1CAM interactions 104099 13385 16416 18186 16402 20740 20739 11772 20404 74947 11771 71770 13193 12805 53378 53321 17967 110651 72821 16728 110862 20111 319504 15481 12757 16536 20266 80297 232910 26417 235281 24046 22325 26413 13430 11773 20265 20742 20269 20112 110880 109700 20741 13000 103967 20743 67071 100039026 18222 26396 13004 19353 16571 13001 26395 16772 16777 20264 269116 399548 67300 640524 20271 20272 20273 20274 110876 13383 13429 18479 11733 11735 13844 12661 16398 11658 16399 53310 21367 226519 73086 56613 22350 17698 19684 13649 12934 213119 71653 53870 18187 56705 16412 16410 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS%REACTOME DATABASE ID RELEASE 57%141405 Inhibition of the proteolytic activity of APC C required for the onset of anaphase by mitotic spindle checkpoint components 66156 52206 668450 12236 12237 22194 52563 56150 59008 99152 56317 75430 216080 107995 69957 217232 52717 68999 68612 17222 DOWNSTREAM TCR SIGNALING%REACTOME DATABASE ID RELEASE 57%202424 Downstream TCR signaling 108723 12504 19186 19188 100041766 216080 57296 67151 12500 66413 19185 66998 53380 12042 19192 26445 17463 19166 216150 16331 69077 26444 12234 26446 26443 26965 74769 18709 14960 14968 14969 22123 59029 77647 19184 22190 19179 20422 26409 667035 19182 192656 19181 23997 66997 68652 12502 21402 12501 22034 16913 240354 228769 93765 70247 19175 67089 19177 103583 19170 21762 23996 103554 16912 19173 18708 19172 18761 18706 16818 12675 19697 18033 73902 18035 18607 19167 16151 26441 16150 19171 66589 19211 26442 26440 3' -UTR-MEDIATED TRANSLATIONAL REGULATION%REACTOME DATABASE ID RELEASE 57%157279 3' -UTR-mediated translational regulation 76808 68028 100043755 19899 67186 20115 57294 667739 67025 27370 65019 67248 666669 100038991 100038875 100040021 432502 66481 100040298 238217 56040 667618 19989 66235 55944 13669 27979 68135 66085 26905 22384 53356 56347 13684 67204 223691 13682 73830 16341 100042807 13681 54709 75705 98221 13665 208643 18458 67891 100042986 100042740 621100 100043295 67097 100043000 625646 67281 633683 667035 666899 16785 100039316 267019 100040970 19941 382492 20055 19951 100042670 68193 665189 668182 19921 20044 668144 100043423 100043893 670832 100043876 629957 225058 22121 75617 667279 76846 27050 100043184 19934 100040331 100043391 319195 68172 241053 100043209 20102 67941 27207 668668 20103 672214 622534 20085 20084 VEGFA-VEGFR2 PATHWAY%REACTOME DATABASE ID RELEASE 57%4420097 VEGFA-VEGFR2 Pathway 15507 17973 57257 20430 230126 83767 242687 18127 22325 15519 330662 18481 56438 224105 19353 13057 26395 67603 13058 319520 17970 17972 17969 102626 235584 26362 27371 26403 16416 12223 54519 100042150 21894 11600 19060 19186 19188 327826 17169 194231 109905 14161 226525 57296 67151 215449 19185 66998 53380 14172 17967 15461 17463 83409 69077 29875 17164 26417 26413 12323 108058 12322 18015 59029 19197 19417 19184 22190 19179 20422 171463 667035 14573 19182 16590 240057 19181 64654 231474 14173 80903 14164 23997 66997 18039 218397 110135 14585 14178 80857 228769 14180 70247 67089 14586 14587 14175 21762 14177 23996 20416 12385 11876 14165 26554 18596 109880 16399 54153 18708 15200 640703 18706 18673 12325 16706 69601 83379 22371 73902 233046 114716 12981 19415 63953 14174 12982 19252 16653 12984 240672 13537 12988 67836 16186 13385 14588 211323 16184 11836 18188 20740 20739 13645 16185 16452 216869 109689 18176 72399 70686 114715 240168 14268 66413 211255 18183 14083 16451 19192 16453 26445 19166 18218 14812 76089 26444 26446 14811 26443 14813 19414 80297 14814 74769 16183 20742 18709 20741 21687 20743 16367 13866 14810 16192 26396 14360 16191 216148 114713 14186 19418 22123 16480 12927 11848 19303 12388 20662 19052 14170 12389 19053 19262 73699 640524 16913 75590 19175 19177 51792 19713 19170 22330 99571 13874 103554 16912 26416 54401 83961 16188 19173 19172 21770 107971 26932 100986 226849 18611 23980 20418 26931 320484 225849 384783 245684 67112 110157 19167 26441 19419 12562 11472 19171 545987 13649 70727 18595 26442 26440 19229 101809 18591 18750 18753 75778 229709 18762 18751 29857 20698 19094 16542 105855 245880 19877 56717 140580 50884 108100 26415 329165 101314 140579 19878 18803 11652 76884 11651 12928 16440 18479 78757 228775 18747 16438 18749 23797 11308 56716 18607 22324 17974 227743 109270 16439 16410 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%R-HSA-427413.1 NoRC negatively regulates rRNA expression 100041953 17749 66420 245841 319181 50724 66467 232440 93762 14884 382522 319176 269003 433759 15182 12572 20467 94246 17420 13433 624153 13436 69833 625328 51788 15077 60406 319149 17191 100043714 66136 21341 21340 15267 20017 319183 21374 70333 667501 22130 57230 319182 319178 319186 319190 21429 75316 64424 20016 20018 20019 319168 21339 66671 319167 71954 20466 23894 13871 13872 209357 14885 319188 15270 319169 78303 116848 TOXICITY OF BOTULINUM TOXIN TYPE B (BONT B)%REACTOME%R-HSA-5250958.1 Toxicity of botulinum toxin type B (BoNT B) 20980 22318 20979 MRNA EDITING: C TO U CONVERSION%REACTOME%R-HSA-72200.1 mRNA Editing: C to U Conversion 69865 11810 HIGHLY CALCIUM PERMEABLE NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%R-HSA-629597.1 Highly calcium permeable nicotinic acetylcholine receptors 11438 110834 110902 108015 11435 11444 110835 11440 108043 DEFECTIVE CYP11A1 CAUSES ADRENAL INSUFFICIENCY, CONGENITAL, WITH 46,XY SEX REVERSAL (AICSR)%REACTOME DATABASE ID RELEASE 57%5579026 Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR) 68165 14148 14149 13070 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE%REACTOME DATABASE ID RELEASE 57%211897 Cytochrome P450 - arranged by substrate type 56448 13107 13087 13088 74134 13106 546726 13082 13110 13116 13077 232174 14149 13070 13075 106648 100040843 72054 19223 13122 110115 13074 17978 104086 20186 13072 13120 320997 20181 631304 13079 13124 13121 13118 21391 64385 17977 208285 13078 622127 545817 13081 244209 102294 13113 13114 13123 72082 13115 107141 13076 71519 18976 72303 68165 14148 18984 56050 MRNA EDITING: A TO I CONVERSION%REACTOME DATABASE ID RELEASE 57%75064 mRNA Editing: A to I Conversion 110532 56417 REGULATION OF TP53 ACTIVITY THROUGH ASSOCIATION WITH CO-FACTORS%REACTOME DATABASE ID RELEASE 57%6804759 Regulation of TP53 Activity through Association with Co-factors 22062 21981 228829 22059 23797 18997 18996 53325 333654 11652 11651 29813 209456 22061 PEPTIDE HORMONE METABOLISM%REACTOME%R-HSA-2980736.1 Peptide hormone metabolism 16334 56373 16573 12873 76703 27226 16000 14607 100038824 14526 72061 20907 67475 11891 11606 14463 11421 93721 211446 20336 12876 18549 16574 50527 53413 17228 13035 70008 14943 56529 17380 102058 69019 13482 66286 236781 107221 13033 12640 18508 12038 242851 21416 18548 16866 16846 233081 66624 76687 16790 239436 13809 66500 22318 107371 11423 12591 69048 225642 16322 16323 64138 22094 210148 105504 16600 17918 18976 16572 14695 16392 64337 14308 69940 16324 70495 16325 16326 66482 234155 KERATAN SULFATE DEGRADATION%REACTOME DATABASE ID RELEASE 57%2022857 Keratan sulfate degradation 15212 15211 14264 18295 75612 27047 12091 116847 16545 17022 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS%REACTOME DATABASE ID RELEASE 57%198693 AKT phosphorylates targets in the nucleus 56458 56484 11652 23797 11651 12912 15370 58988 DEFECTIVE ST3GAL3 CAUSES MCT12 AND EIEE15%REACTOME%R-HSA-3656243.1 Defective ST3GAL3 causes MCT12 and EIEE15 14264 18295 27047 116847 16545 17022 O-LINKED GLYCOSYLATION%REACTOME DATABASE ID RELEASE 57%5173105 O-linked glycosylation 80294 78754 100039649 171212 13138 20357 272411 140474 20356 207596 17829 100689 233744 56386 231727 224697 56336 20448 97440 108760 271127 14426 108154 73732 208936 231050 239337 210417 223838 227327 16795 271786 654821 330119 17063 240913 210004 216725 229595 18636 66548 11504 20447 59048 30806 20446 330267 23794 269328 108153 53625 108148 77739 14425 108105 207839 14423 232984 240322 26887 21826 14537 21825 241391 72297 224116 353328 381694 94192 212996 72077 16494 333424 99011 71685 235130 67909 237360 269959 243369 279028 77794 228366 233733 217734 56229 68273 230145 20442 108150 20443 226866 20440 20444 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC%REACTOME DATABASE ID RELEASE 57%389957 Prefoldin mediated transfer of substrate to CCT TriC 545486 22153 56612 73710 227613 67199 22151 11461 18637 22147 67951 22142 22327 22146 109054 22152 22145 12466 12467 12469 12465 21454 12462 12461 12464 12468 14976 ERBB2 REGULATES CELL MOTILITY%REACTOME%R-HSA-6785631.2 ERBB2 Regulates Cell Motility 13874 12223 211323 83961 100042150 13367 11848 15200 13645 76890 13866 18183 13649 INTERACTION BETWEEN PHLDA1 AND AURKA%REACTOME%R-HSA-8854521.1 Interaction between PHLDA1 and AURKA 20878 21664 ACTIVATION AND OLIGOMERIZATION OF BAK PROTEIN%REACTOME DATABASE ID RELEASE 57%111452 Activation and oligomerization of BAK protein 12122 12018 INHIBITION OF TSC COMPLEX FORMATION BY PKB%REACTOME%R-HSA-165181.1 Inhibition of TSC complex formation by PKB 64930 11652 22084 ACTIVATION OF DNA FRAGMENTATION FACTOR%REACTOME DATABASE ID RELEASE 57%211227 Activation of DNA fragmentation factor 14958 12367 80838 50708 434174 97165 13368 13347 16211 50709 14957 56702 16646 RRNA PROCESSING IN THE MITOCHONDRION%REACTOME%R-HSA-8868766.1 rRNA processing in the mitochondrion 68017 15108 66132 224481 217038 68626 52575 69821 67390 72181 FUSION AND UNCOATING OF THE INFLUENZA VIRION%REACTOME%R-HSA-168270.1 Fusion and Uncoating of the Influenza Virion GRB7 EVENTS IN ERBB2 SIGNALING%REACTOME DATABASE ID RELEASE 57%1306955 GRB7 events in ERBB2 signaling 211323 13866 100042150 14786 ABORTIVE ELONGATION OF HIV-1 TRANSCRIPT IN THE ABSENCE OF TAT%REACTOME DATABASE ID RELEASE 57%167242 Abortive elongation of HIV-1 transcript in the absence of Tat 67710 17749 66420 245841 24116 57314 27632 20021 69241 58202 68092 69833 433702 68705 20022 67655 69920 231329 20924 20922 98053 100043714 20020 DEFECTIVE ABCC8 CAN CAUSE HYPOGLYCEMIAS AND HYPERGLYCEMIAS%REACTOME%R-HSA-5683177.1 Defective ABCC8 can cause hypoglycemias and hyperglycemias 16514 20927 LDL ENDOCYTOSIS%REACTOME%R-HSA-171052.4 LDL endocytosis 11771 71770 67300 103161 100017 11772 12757 232910 100102 11773 238055 16835 MEIOTIC RECOMBINATION%REACTOME DATABASE ID RELEASE 57%912446 Meiotic recombination 17535 15267 319183 319181 319182 319178 19891 319186 319190 68240 232440 12189 11920 12567 319168 213389 382522 319167 319176 12190 21975 17350 19360 114714 319152 225182 13404 27354 19361 55993 624153 19183 217716 625328 12566 76915 51788 15077 17687 26972 319188 68275 319149 15270 12144 319169 78303 104271 FIBRONECTIN MATRIX FORMATION%REACTOME%R-HSA-1566977.1 Fibronectin matrix formation 16402 14268 16412 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN%REACTOME DATABASE ID RELEASE 57%174154 APC C:Cdc20 mediated degradation of Securin 66156 52206 668450 19186 22194 19188 75430 216080 57296 67151 66413 19185 66998 53380 52717 19192 26445 17463 19166 69077 26444 26446 26443 52563 99152 69957 68999 68612 17222 22123 59029 19184 19179 22190 20422 667035 19182 19181 23997 66997 16913 228769 70247 19175 67089 19177 19170 21762 23996 103554 16912 19173 19172 59008 56317 73902 19167 26441 107995 19171 217232 26442 26440 30939 CELLULAR SENESCENCE%REACTOME%R-HSA-2559583.1 Cellular Senescence 13626 15977 75560 12579 14958 16193 12576 66403 12578 15364 15361 170644 80838 50708 12571 13557 19645 12575 50709 13555 21781 17165 242705 245688 26420 12418 16476 19646 26414 26398 56371 26397 30951 26419 100043858 102626 12580 12567 20683 12447 26416 19763 19697 18033 26399 15901 14281 319169 13619 66156 14056 17535 76850 216850 241915 52206 236511 26921 668450 54383 26408 319181 665113 50932 16175 22194 494448 232440 75430 216080 23872 19094 23871 13875 11920 52717 382522 77683 319176 110651 19821 12448 17164 22059 20111 26400 26417 52563 26413 99152 23939 20112 497652 624153 21749 28113 625328 12566 101185 51788 15077 57321 69957 12608 68999 319149 68612 29817 17222 22166 52615 15267 319183 110147 22190 319182 21750 319178 667035 319186 319190 12427 213988 14957 56702 104248 15260 20848 319168 16906 319167 217351 233833 19360 319152 12416 17246 81601 59008 214150 56317 27354 12151 217232 319188 15270 78303 17454 12428 OREXIN AND NEUROPEPTIDES FF AND QRFP BIND TO THEIR RESPECTIVE RECEPTORS%REACTOME%R-HSA-389397.1 Orexin and neuropeptides FF and QRFP bind to their respective receptors 104443 230777 229214 237362 15171 54615 227717 387285 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT%REACTOME DATABASE ID RELEASE 57%201681 TCF dependent signaling in response to WNT 14370 66313 13543 14368 207742 14367 22418 57265 66413 19192 26445 19166 103236 26444 27373 26446 26443 13000 100039026 56438 14362 21416 11798 14366 22123 12914 328572 56505 19052 12389 19053 73699 21752 381022 16913 19175 19177 51792 20586 17869 19170 240756 103554 94253 16912 59036 11789 80288 56637 213464 93687 19173 72345 19172 21770 23808 26932 21414 226849 16842 12387 21415 12005 26931 77578 225849 103573 68911 21887 72135 19167 26441 19171 234130 84035 13380 73016 16973 26442 56811 26440 319169 14296 20674 20675 22415 67087 20671 20668 17283 22423 319181 68339 19186 20682 19188 212398 20187 20677 232440 319478 13016 67772 24117 20319 57296 22416 67151 216795 19185 66998 53380 20679 20890 68031 73739 20680 17463 74499 22417 382522 69077 20377 16974 319176 22408 12234 433759 329252 22631 239405 74493 228770 107515 14160 72780 624153 625328 51788 15077 407821 192199 100683 319149 84092 15267 319183 59029 19184 13001 21888 22190 19179 319182 20422 21885 319178 21886 319186 667035 319190 19182 19181 23997 66997 11652 11651 319168 228769 214498 70247 67089 235497 319167 21762 23996 21951 26554 13542 13544 12006 319152 81601 18719 73902 319188 15270 78303 PTK6 EXPRESSION%REACTOME DATABASE ID RELEASE 57%8849473 PTK6 Expression 13819 20459 15251 75273 14815 AMINE LIGAND-BINDING RECEPTORS%REACTOME%R-HSA-375280.2 Amine ligand-binding receptors 243764 213788 15563 209512 15562 215855 15560 15550 15566 15565 15552 15551 15559 15558 382348 15557 15466 11555 99296 15465 13492 225192 13488 11551 215854 11553 13489 11548 11549 12671 111174 11550 12669 12672 18241 503558 13490 11552 13491 11554 11556 LACTOSE SYNTHESIS%REACTOME DATABASE ID RELEASE 57%5653890 Lactose synthesis 20525 14595 16770 AUTODEGRADATION OF CDH1 BY CDH1:APC C%REACTOME%R-HSA-174084.1 Autodegradation of Cdh1 by Cdh1:APC C 66156 52206 668450 19186 22194 19188 75430 216080 57296 67151 66413 19185 66998 53380 52717 19192 26445 17463 19166 69077 26444 26446 26443 52563 99152 69957 68999 68612 17222 22123 59029 19184 19179 22190 20422 667035 19182 56371 19181 23997 66997 16913 228769 70247 19175 67089 19177 19170 21762 23996 16912 19173 19172 59008 56317 19167 26441 19171 217232 26442 26440 B CELL ACTIVATION%REACTOME%R-HSA-983705.1 B Cell Activation 108723 12402 12042 17973 17096 12229 103583 12223 100042150 19186 19188 327826 57296 67151 18710 19185 66998 53380 14172 15461 17463 69077 12234 12912 26417 26413 59029 19184 19179 22190 20422 26409 667035 19182 16590 19181 64654 80903 14173 23997 14164 66997 14178 240354 228769 80857 70247 14180 67089 12483 21762 14175 23996 14177 14165 18596 17060 83490 15985 18708 208650 15200 12518 18706 640703 26377 12143 16818 83379 73902 14174 16653 58194 211323 20963 13645 18176 240168 66413 18183 19192 26445 19166 15170 12576 26444 26446 26443 26965 74769 12575 18707 18709 16367 13866 14360 14186 22123 19052 20662 19053 22063 14170 73699 21402 16913 19175 51792 19177 19170 13874 103554 16912 56637 83961 19173 21770 19172 26932 226849 26931 225849 12675 384783 19697 18033 67112 18036 18035 19167 16151 26441 19419 16150 19171 13649 18595 26442 26440 18591 16334 76850 236511 19247 16337 75778 15370 229709 12519 12524 20866 18751 109305 269717 606496 18037 19696 244650 12015 56717 22084 77647 239528 12371 98432 117150 18803 234779 56458 56484 213988 11652 18717 12478 11651 15937 16440 78757 228775 12487 16438 217351 233833 23797 67605 18720 17246 56716 18719 214150 108083 18607 14388 22324 19211 227743 18718 109270 17454 16439 20811 58988 GRB2 EVENTS IN ERBB2 SIGNALING%REACTOME%R-HSA-1963640.3 GRB2 events in ERBB2 signaling 13874 12223 211323 83961 100042150 15200 13645 18176 20662 13866 18183 13649 16653 15461 SIGNALING BY FGFR2%REACTOME DATABASE ID RELEASE 57%5654738 Signaling by FGFR2 17346 12402 24064 56438 26395 59013 67603 319520 98758 15382 235584 26403 16416 12223 54519 100042150 21894 11600 19060 19186 19188 327826 17169 194231 109905 14161 226525 57296 67151 215449 18710 19185 66998 53380 14172 17967 15461 17463 83409 69077 29875 12912 26417 26413 68092 433702 12323 108058 12322 18015 59029 19197 19417 19184 19179 22190 20422 171463 14573 667035 19182 16590 240057 19181 64654 231474 14173 80903 14164 23997 66997 18039 218397 110135 14585 14178 80857 228769 14180 70247 67089 14586 14587 14175 21762 14177 23996 20416 11876 14165 26554 18596 109880 16399 54153 18708 15200 640703 18706 18673 12325 16818 16706 69601 83379 22371 73902 233046 114716 12981 19415 63953 14174 12982 19252 16653 12984 240672 13537 12988 67836 16186 13385 14588 211323 16184 11836 18188 20740 20739 13645 16185 16452 216869 109689 18176 72399 70686 114715 240168 14268 66413 211255 18183 14083 16451 19192 16453 26445 19166 18218 12576 14812 76089 26444 26446 14811 26443 14813 19414 80297 14814 12575 74769 16183 20742 18707 18709 20741 21687 20743 16367 13866 14810 16192 26396 14360 16191 216148 114713 14186 19418 22123 20662 19052 14170 19053 19262 73699 640524 16913 75590 19175 19177 51792 19713 19170 22330 99571 13874 103554 16912 54401 83961 56637 16188 19173 19172 21770 107971 26932 100986 226849 18611 23980 20418 26931 320484 225849 384783 12675 245684 67112 110157 19167 26441 19419 11472 19171 545987 13649 70727 18595 26442 26440 101809 18591 18750 19088 16334 67710 76850 18753 17749 18754 66420 236511 245841 19247 16337 75778 15370 18752 104110 229709 20021 12519 69241 12524 76936 77411 21841 93686 19205 606496 69833 68705 20022 69920 231329 21843 98053 14181 72514 100043714 20020 244650 18573 12015 56717 22084 224129 77647 11513 11512 239528 11515 11514 12371 98432 117150 18803 56458 56484 213988 12326 11652 18717 12478 11651 15937 16440 78757 228775 12487 110355 18747 18574 16438 18749 217351 210044 18575 432530 233833 23797 104111 67605 18720 17246 56716 18719 214150 108083 19087 19085 18607 19084 14388 22324 19211 227743 18718 109270 17454 16439 58988 O-GLYCOSYLATION OF TSR DOMAIN-CONTAINING PROTEINS%REACTOME DATABASE ID RELEASE 57%5173214 O-glycosylation of TSR domain-containing proteins 80294 108153 77739 20357 240322 21826 21825 207596 20356 100689 233744 381694 224697 271127 108154 235130 208936 237360 269959 243369 239337 77794 279028 210417 223838 56229 330119 240913 229595 216725 18636 66548 226866 11504 30806 330267 23794 INTEGRATION OF PROVIRUS%REACTOME DATABASE ID RELEASE 57%162592 Integration of provirus 268373 15361 108138 22596 319583 14375 101739 23825 16646 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 57%112297 Post-Elongation Processing of Intronless pre-mRNA 98985 67337 228410 67332 68219 20638 51786 20492 68092 116748 54196 384091 433702 54451 54188 108062 66899 243963 18789 666609 72290 94230 269061 NEGATIVE REGULATION OF MAPK PATHWAY%REACTOME%R-HSA-5675221.1 Negative regulation of MAPK pathway 11836 22190 26395 19060 667035 17169 18176 19052 231474 67603 72399 19053 70686 73699 319520 75590 15461 51792 18218 54401 109880 21770 26932 226849 26417 23980 26931 26413 16706 225849 110157 63953 26396 19252 16653 240672 13537 235584 SIALIC ACID METABOLISM%REACTOME DATABASE ID RELEASE 57%4085001 Sialic acid metabolism 12764 241159 20452 19025 67311 235504 50935 24060 20454 50798 20451 50877 20448 26938 225742 54613 240119 20450 74091 241230 20449 20442 20445 20443 18010 20447 12091 20446 20440 23956 94181 20444 SIGNALING BY CYTOSOLIC FGFR1 FUSION MUTANTS%REACTOME%R-HSA-1839117.2 Signaling by cytosolic FGFR1 fusion mutants 21848 20851 360013 20850 14389 76007 18708 18706 75296 110279 67529 20848 432508 20846 13047 POST-TRANSCRIPTIONAL SILENCING BY SMALL RNAS%REACTOME DATABASE ID RELEASE 57%426496 Post-transcriptional silencing by small RNAs 217351 213988 76850 233833 236511 239528 214150 SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE%REACTOME DATABASE ID RELEASE 57%1660517 Synthesis of PIPs at the late endosome membrane 17772 103199 77116 170749 234729 18711 18704 75669 54384 225326 EPH-EPHRIN MEDIATED REPULSION OF CELLS%REACTOME%R-HSA-3928665.2 EPH-ephrin mediated repulsion of cells 11487 19353 17390 11772 11771 59287 71770 67300 17395 13429 22612 13848 13636 270190 13838 13845 13839 17096 13641 13836 57257 13840 13844 74325 13841 208117 13846 13638 12757 232910 13643 22325 13639 13642 11773 13637 13842 13835 19165 100039623 100042305 14360 21844 13640 13837 IRAK1 RECRUITS IKK COMPLEX%REACTOME DATABASE ID RELEASE 57%937039 IRAK1 recruits IKK complex 16151 67245 16150 22034 93834 66589 93765 240518 12675 16179 PROGRAMMED CELL DEATH%REACTOME%R-HSA-5357801.1 Programmed Cell Death 11783 20740 18107 56455 66413 14083 19192 94275 26445 13169 19166 16646 14958 26444 26446 670717 80838 26443 50708 50709 13555 21781 11798 22123 224105 22030 434174 14082 97165 21933 13368 14102 13347 14103 12370 22035 66593 71609 19766 26419 16913 19175 22627 19177 19170 21898 106759 103554 16912 142980 11789 12122 54401 225471 56532 19173 19172 19167 17087 26441 19171 26442 26440 22062 21981 18753 19186 100039786 19188 11797 16211 12028 57296 67151 11796 19185 66998 53380 17463 209456 69077 22061 12475 55948 68097 22059 22631 22629 22628 74568 74006 13176 13143 72993 12018 269582 11518 13144 107448 69635 19057 14939 107449 171543 12368 12369 19877 12015 12367 59029 227753 21873 14272 19184 13511 19179 22190 20422 667035 19182 27061 12371 223255 20230 19181 13510 12169 109620 23997 18772 66997 13512 14957 11652 56702 11651 18810 228769 16906 70247 14453 67089 21872 70415 56215 21762 22352 23996 12550 23797 18761 12043 12125 12048 78514 19058 73902 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES%REACTOME%R-HSA-425393.2 Transport of inorganic cations anions and amino acids oligopeptides 231583 235504 83429 109552 142681 236727 331004 77031 14411 236794 105243 277973 226999 110895 21366 50934 20531 103098 30962 102680 240215 22598 23985 20544 56774 56643 105727 20498 330836 20505 20540 317750 20495 20497 20496 110891 214111 57738 54403 11989 20513 22348 65221 27376 107723 110893 76376 215113 53896 171429 59033 94229 72401 218756 216225 20515 20512 246049 20504 20511 238384 20535 94249 242607 20532 74338 26570 20516 215335 20541 320718 67760 20499 13487 13521 20536 20514 216227 20533 640703 69354 67582 100561 20510 55963 17254 232156 57138 209837 140919 170756 11987 76257 114479 208890 20539 DEGRADATION OF GLI1 BY THE PROTEASOME%REACTOME DATABASE ID RELEASE 57%5610780 Degradation of GLI1 by the proteasome 19186 19188 57296 67151 66413 19185 66998 53380 19192 17463 26445 19166 69077 26444 12234 26446 26965 26443 14632 56438 18222 22123 59029 19184 19179 22190 20422 667035 19182 19181 23997 24069 66997 21402 16396 16913 228769 70247 19175 67089 19177 19170 18747 21762 23996 103554 18749 16912 19173 19172 73902 19167 26441 19171 26442 26440 MAP2K AND MAPK ACTIVATION%REACTOME DATABASE ID RELEASE 57%5674135 MAP2K and MAPK activation 16416 54519 11836 21894 26395 171463 17169 216869 194231 109689 109905 18176 14161 215449 14268 110135 15461 83409 22330 99571 29875 54401 109880 16399 26417 23980 26413 16706 245684 22371 110157 545987 26396 16653 12988 67836 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX%REACTOME DATABASE ID RELEASE 57%204174 Regulation of pyruvate dehydrogenase (PDH) complex 382051 27402 319518 381511 235339 18604 27273 13382 20181 19015 18597 228026 68263 236900 NEUROPHILIN INTERACTIONS WITH VEGF AND VEGFR%REACTOME%R-HSA-194306.1 Neurophilin interactions with VEGF and VEGFR 18186 16542 18187 14254 RHO GTPASES ACTIVATE RHOTEKIN AND RHOPHILINS%REACTOME%R-HSA-5666185.1 RHO GTPases Activate Rhotekin and Rhophilins 100039683 11853 20166 11848 22342 11852 76378 14787 52428 COPI-DEPENDENT GOLGI-TO-ER RETROGRADE TRAFFIC%REACTOME%R-HSA-6811434.1 COPI-dependent Golgi-to-ER retrograde traffic 16581 16554 209737 100042773 16563 16565 11842 16573 16564 54161 26951 668303 66251 20932 72772 11840 67023 74947 16569 224630 77038 19324 16562 71819 105785 240641 232943 56447 20333 70218 16552 18195 54160 50797 11844 26934 66111 107338 70349 12847 19348 16561 56358 76308 16560 16571 228998 16579 66913 269152 108123 108124 213827 75050 11843 73470 16568 16570 16572 73804 74764 71116 59042 228421 67511 110033 286942 100042343 319991 16558 229841 68137 16594 16593 17957 16551 TELOMERE MAINTENANCE%REACTOME%R-HSA-157579.1 Telomere Maintenance 18973 19687 69263 67967 19718 18972 319181 18538 19891 69745 68240 232440 18971 382522 319176 327762 16881 14156 59001 497652 624153 72151 21749 106344 28113 101185 51788 66979 57321 18974 68275 15267 319183 18969 19075 56505 21750 319182 319178 319186 52530 319190 245474 216853 20174 21752 319168 319167 319152 319188 18968 15270 19076 78303 319169 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY%REACTOME%R-HSA-399721.1 Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity 12323 18750 13385 108058 53623 12322 81905 243547 18752 54377 18751 11771 13383 238276 18195 17920 17246 12325 18693 74053 14799 21912 14802 54376 14800 12300 DEFECTIVE AVP CAUSES NEUROHYPOPHYSEAL DIABETES INSIPIDUS (NDI)%REACTOME DATABASE ID RELEASE 57%5619099 Defective AVP causes neurohypophyseal diabetes insipidus (NDI) 12000 26361 54140 11998 ERBB2 ACTIVATES PTK6 SIGNALING%REACTOME DATABASE ID RELEASE 57%8847993 ERBB2 Activates PTK6 Signaling 13874 12223 211323 83961 13866 20459 100042150 18183 13649 15200 13645 UBIQUINOL BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 57%2142789 Ubiquinol biosynthesis 230027 12850 217707 71883 52064 71365 56075 FCGR ACTIVATION%REACTOME%R-HSA-2029481.1 FCGR activation 15162 14131 246256 17096 12502 20963 22612 14191 14360 14129 S PHASE%REACTOME DATABASE ID RELEASE 57%69242 S Phase 18973 19687 69263 67967 19718 18972 18538 19891 69745 68240 18971 66413 19192 26445 19166 12576 17187 26444 26446 26443 26965 67849 12572 19645 12575 17420 218914 59001 72151 106344 27401 66979 18974 68275 22123 20459 56371 71988 77805 21402 12567 16913 12447 12443 50793 19175 19177 17869 19170 66671 54124 103554 16912 19173 19172 19167 26441 19171 26442 26440 22390 19186 19188 57296 67151 19185 66998 53380 18392 26428 18393 17463 26429 69077 327762 12448 16881 14156 13006 19357 12531 12544 20842 12566 109145 272551 78833 69270 59029 18969 19075 19184 22190 19179 20422 667035 19182 12427 19181 23997 66997 71521 228769 70247 67089 100710 21762 23996 24061 17215 17219 17217 56452 20843 66634 67177 73902 23834 12530 17216 18968 19076 17220 12428 17218 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS%REACTOME%R-HSA-163560.1 Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis 18749 12140 23945 16204 19045 14080 16890 21884 19046 75497 16592 12389 103968 14077 11770 19047 14079 67469 18747 FGFR2C LIGAND BINDING AND ACTIVATION%REACTOME%R-HSA-190375.2 FGFR2c ligand binding and activation 64654 80903 14173 14164 14172 80857 14180 14175 14177 NGF PROCESSING%REACTOME DATABASE ID RELEASE 57%167060 NGF processing 18049 18552 18550 18553 GAMMA-CARBOXYLATION, TRANSPORT, AND AMINO-TERMINAL CLEAVAGE OF PROTEINS%REACTOME%R-HSA-159854.2 Gamma-carboxylation, transport, and amino-terminal cleavage of proteins 14456 14068 14058 14071 18550 14061 66901 56316 19128 19123 MYD88 DEFICIENCY (TLR2 4)%REACTOME DATABASE ID RELEASE 57%5602498 MyD88 deficiency (TLR2 4) 21899 266632 12475 12229 17087 117149 24088 21897 17874 21898 12491 ASSEMBLY OF THE ORC COMPLEX AT THE ORIGIN OF REPLICATION%REACTOME DATABASE ID RELEASE 57%68616 Assembly of the ORC complex at the origin of replication 56452 18392 26428 50793 18393 26429 TRANSLESION SYNTHESIS BY POLH%REACTOME DATABASE ID RELEASE 57%110320 Translesion Synthesis by POLH 19687 69263 19718 80905 22190 18538 22230 19891 667035 68240 269523 72151 106344 68275 68098 244666 217365 REGULATION OF DNA REPLICATION%REACTOME DATABASE ID RELEASE 57%69304 Regulation of DNA replication 70024 19186 19188 57296 67151 66413 19185 66998 53380 18392 19192 26428 18393 26445 17463 26429 19166 69077 12576 26444 26446 26443 13557 19645 12575 13555 12566 242705 22123 59029 19184 22190 19179 20422 57441 667035 56371 19182 12427 19181 23997 66997 16913 228769 50793 19175 70247 19177 67089 19170 21762 23996 17215 17219 103554 17217 16912 56452 19173 66634 19172 67177 73902 19167 26441 23834 19171 17216 26442 26440 17220 12428 17218 SIGNALING BY ACTIVIN%REACTOME%R-HSA-1502540.1 Signaling by Activin 269275 11481 17128 17127 17126 83554 66556 14313 14106 16323 16324 11479 11480 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1%REACTOME%R-HSA-113501.1 Inhibition of replication initiation of damaged DNA by RB1 E2F1 19052 19053 73699 18969 19075 18968 51792 19645 19076 13555 21781 COMMON PATHWAY OF FIBRIN CLOT FORMATION%REACTOME%R-HSA-140875.2 Common Pathway of Fibrin Clot Formation 19152 19124 268591 19128 56744 19123 74145 14161 15160 20720 14058 68891 11905 14069 110135 14062 21824 14060 14061 14067 99571 SIGNALING BY NOTCH1%REACTOME%R-HSA-1980143.2 Signaling by NOTCH1 18519 11487 14357 227325 13386 56233 11491 74198 333639 216869 109689 59287 54485 13388 16450 207521 16449 12805 433586 103806 79221 170787 225164 208727 15208 240055 433759 15205 26965 15213 15182 76580 15185 232232 70315 56198 15214 15184 264064 56438 18222 12914 20185 328572 20602 15251 21888 22190 21885 18011 21886 667035 81004 14534 21402 16396 21372 17869 15183 51813 270118 208117 19165 19664 100039623 100042305 18128 SPERM:OOCYTE MEMBRANE BINDING%REACTOME%R-HSA-1300652.1 Sperm:Oocyte Membrane Binding 71564 12527 73456 75510 B-WICH COMPLEX POSITIVELY REGULATES RRNA EXPRESSION%REACTOME%R-HSA-5250924.1 B-WICH complex positively regulates rRNA expression 18519 17749 66420 245841 319181 232440 93762 382522 319176 319955 624153 69833 625328 51788 15077 18432 319149 100043714 110052 66136 21341 21340 15267 20017 319183 70333 21374 667501 328572 11461 319182 319178 319186 319190 75316 64424 20016 14534 20018 81898 20019 21339 319168 319167 56637 56200 22385 319188 15270 78303 319169 MINUS-STRAND DNA SYNTHESIS%REACTOME%R-HSA-164516.1 Minus-strand DNA synthesis 268373 ERYTHROCYTES TAKE UP OXYGEN AND RELEASE CARBON DIOXIDE%REACTOME%R-HSA-1247673.1 Erythrocytes take up oxygen and release carbon dioxide 12349 12351 20533 11826 15122 15129 12346 19743 HEMOSTASIS%REACTOME%R-HSA-109582.1 Hemostasis 16822 16362 230398 14706 15977 14696 54131 14688 22145 14708 14693 14709 14697 16363 99982 18439 110893 12527 54368 14723 14729 12491 14724 223864 22138 11820 20541 56508 14699 66066 14700 14701 14695 18755 14704 14702 331374 56077 14710 14065 64337 66082 320127 11537 380921 110524 12759 104418 17480 13139 14062 14673 213119 110197 76192 231871 21832 269060 11552 14064 217480 66866 109232 16416 20255 74840 16402 54519 20344 14828 21767 19073 80884 21894 13601 11600 108101 16784 21346 56541 117586 67059 20716 268936 109905 22388 14161 80718 94175 26968 11747 215449 11625 18710 227612 19039 71946 13041 19395 667310 12306 240334 15461 68038 18407 16427 12512 218454 104009 18816 53612 12321 20911 72017 433759 22341 67072 16426 235505 22340 26417 57349 56744 26413 11818 54216 109700 110891 21922 60595 27999 56055 12258 385643 71660 68117 14205 56193 70945 20343 16408 83995 12343 110135 13052 16401 12340 192176 14682 20416 14675 16409 21390 14676 14672 14127 14674 16399 80879 16414 18761 57274 640703 20501 16818 12215 22371 58217 12981 12982 16653 12984 12988 270152 16186 16554 209737 16621 16184 23945 20963 16564 13645 16185 16452 216869 109689 18176 14268 11806 14083 16451 16453 238055 16331 15170 70218 21857 20692 74769 16183 239273 18707 232345 18709 21687 16192 15129 14360 16191 19348 16561 268373 21808 11931 12927 16571 11848 20662 12389 18125 22065 18126 21809 22330 99571 16568 16570 16572 16188 73804 215789 11804 74764 27359 22068 223601 12331 67988 21859 20363 75396 74145 11932 110033 11938 110157 286942 53313 19419 11937 11472 381290 229841 320707 16593 67972 16456 16551 11933 18591 18750 19088 19152 18753 18754 19247 26946 94176 18752 16000 16002 109552 15234 11941 242202 207728 23984 19124 268591 625328 15077 319149 18788 18573 20737 20719 20339 78287 12523 54123 19261 66053 12481 67374 18792 12261 16149 18106 21788 11602 18803 17289 17540 15160 58802 20720 16531 68891 11905 11652 12506 108078 21824 11651 14060 241489 13449 19092 16440 16423 54611 14066 72413 16400 18585 50915 18576 72461 435726 18747 11601 16533 18574 20345 16438 18749 109711 16403 16398 23797 17136 114714 19363 20725 19087 58992 19085 69524 18607 20194 19084 16411 83964 22324 109821 17319 11657 20340 19222 16412 16410 19246 16439 16581 16565 60596 17133 234889 668303 54195 108829 57440 238130 74947 56697 56248 252966 15353 259300 18022 14678 20399 14677 22761 14679 63955 70839 17863 208869 319899 12419 16580 18441 16578 16923 14464 17096 50934 57257 30962 14191 20909 18127 330836 12631 22325 20540 11350 12505 330662 242851 16797 14726 243816 56760 19353 106722 11674 13660 217864 23921 11640 14461 14460 17134 67299 68732 12345 15135 76088 68813 15132 14462 17135 22762 75974 210293 20912 16563 16573 22390 16569 12568 16562 71819 240641 232943 14463 16552 20703 18783 22059 22631 26934 12566 104709 16560 16579 53896 19128 19123 269152 30955 26570 22041 75050 320207 73470 20466 14389 18708 271457 18706 17254 228421 22365 319991 16558 16594 18787 20539 14061 15182 12914 328572 22339 21825 19052 19053 73699 21803 51792 26416 21770 26932 226849 26931 225849 14068 14058 14071 14069 18613 14067 19156 217837 18762 18436 18751 20866 231602 94045 228139 18440 18438 109305 14465 16728 269717 11551 170731 11553 320202 14456 18643 14786 67414 234779 56212 12928 22612 19354 11852 18793 18815 18791 TRP CHANNELS%REACTOME DATABASE ID RELEASE 57%3295583 TRP channels 17364 22368 26946 193034 68279 56407 226025 22063 58800 68667 22065 194352 56843 225997 22066 246788 171166 22068 63873 64177 22067 28240 94178 277328 171382 SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN%REACTOME%R-HSA-422085.1 Synthesis, secretion, and deacylation of Ghrelin 16334 27226 11423 16000 56529 69019 66286 14526 12038 18548 16600 234155 16846 66624 76687 OTHER SEMAPHORIN INTERACTIONS%REACTOME%R-HSA-416700.1 Other semaphorin interactions 214968 67784 140571 22177 243743 18845 83433 20356 109700 20354 20358 12517 20349 16412 18844 19264 54712 20361 20351 STEROLS ARE 12-HYDROXYLATED BY CYP8B1%REACTOME%R-HSA-211994.1 Sterols are 12-hydroxylated by CYP8B1 19223 13124 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES%REACTOME DATABASE ID RELEASE 57%168180 TRAF6 Mediated Induction of proinflammatory cytokines 19094 11596 110651 20210 12234 17164 72349 26965 20111 12912 26400 26417 26413 23939 20112 257632 26420 107607 11909 16476 17260 13712 434174 22190 26414 108960 26395 26409 667035 26398 26397 192656 17874 19052 67603 19053 100040260 319520 73699 26419 68652 11820 21402 66724 102626 22034 20203 66513 17258 51792 103583 26416 21770 12675 19697 18033 26399 18036 18035 231130 16151 18034 73086 16150 13211 14281 26410 235584 16179 ALPHA-LINOLENIC ACID (ALA) METABOLISM%REACTOME%R-HSA-2046106.1 alpha-linolenic acid (ALA) metabolism 20280 68801 54326 56473 170789 11666 113868 12686 76267 15488 54325 14081 DOPAMINE RECEPTORS%REACTOME%R-HSA-390651.1 Dopamine receptors 13489 13492 13490 13488 13491 NEGATIVE REGULATION OF FGFR3 SIGNALING%REACTOME DATABASE ID RELEASE 57%5654732 Negative regulation of FGFR3 signaling 109880 19247 22190 17346 26417 667035 327826 12402 26413 24064 64654 19052 14173 80903 19053 14164 14172 80857 14180 51792 14175 INHIBITION OF SIGNALING BY OVEREXPRESSED EGFR%REACTOME%R-HSA-5638303.1 Inhibition of Signaling by Overexpressed EGFR 13649 13645 TP53 REGULATES TRANSCRIPTION OF CELL DEATH GENES%REACTOME%R-HSA-5633008.1 TP53 Regulates Transcription of Cell Death Genes 22062 12368 11783 21981 68428 64058 12914 60599 21933 14102 12362 225655 57913 12028 12366 11920 17988 66494 16009 209456 68742 268973 22061 11799 19352 12122 71361 69076 56187 22059 66813 12177 12905 12053 12662 FRUCTOSE CATABOLISM%REACTOME%R-HSA-70350.3 Fructose catabolism 11668 230163 225913 235582 16548 MRNA EDITING%REACTOME DATABASE ID RELEASE 57%75072 mRNA Editing 69865 110532 11810 56417 MAPK6 MAPK4 SIGNALING%REACTOME%R-HSA-5687128.2 MAPK6 MAPK4 signaling 76850 236511 19186 19188 545156 57296 67151 66413 19185 66998 53380 19192 15507 26445 17463 19166 69077 58804 26444 260409 26446 235072 19374 26443 19373 17979 81489 18612 104252 225724 50772 218294 229776 140486 12534 17165 18481 22123 224105 16476 59029 19353 19184 22190 19179 239528 20422 667035 19182 19181 56458 56484 213988 23997 66997 16913 18479 228769 19175 70247 19177 67089 17869 19170 18747 21762 12445 23996 18749 103554 217351 16912 233833 19173 19172 103573 214150 73902 19167 26441 19171 26442 26440 17454 CATABOLISM OF GLUCURONATE TO XYLULOSE-5-PHOSPHATE%REACTOME%R-HSA-5661270.1 Catabolism of glucuronate to xylulose-5-phosphate 58810 102448 67880 68631 20322 DEFECTIVE CSF2RA CAUSES PULMONARY SURFACTANT METABOLISM DYSFUNCTION 4 (SMDP4)%REACTOME DATABASE ID RELEASE 57%5688890 Defective CSF2RA causes pulmonary surfactant metabolism dysfunction 4 (SMDP4) 12982 12984 20390 20389 20388 20387 NEURONAL SYSTEM%REACTOME%R-HSA-112316.4 Neuronal System 12295 12297 12298 14816 13823 228836 245537 14706 26558 108071 14696 26557 14678 244310 14677 20907 14679 55991 226352 54525 14688 57267 14708 22343 14693 380785 14709 13169 108030 217692 14697 12361 72258 16528 16526 211468 242851 20513 241794 223604 22348 67498 12889 238271 22318 16510 268860 192775 68507 16499 20517 16504 382571 16490 16492 240595 16491 226922 225030 16527 66733 16485 20512 98741 14417 380728 20511 16539 63993 16512 233977 16497 242607 16538 27204 20614 214579 99738 216456 13162 242151 20965 16500 16502 65106 238276 170738 67111 16493 67760 268345 16498 14660 240444 16495 12647 238076 60613 14699 224997 66066 20980 14700 171180 14701 106025 20508 243961 327814 56376 26556 192167 16523 14695 20964 22342 19339 18190 214084 53310 14704 22249 107065 14702 20510 54526 14415 242667 14710 20518 20910 64337 13002 18189 319924 269587 74342 60510 216028 13822 216856 23859 20927 11784 58234 20979 217826 20928 332396 15461 110651 14615 18195 20111 16514 12912 211480 16508 26413 20112 16511 17161 56543 16506 16535 74571 12323 108058 12322 14617 19417 18039 109880 17920 640703 12325 13385 11447 11449 11771 52150 16530 84036 19268 16525 243616 20168 14411 14251 14412 140492 232333 140493 56379 15168 406218 19280 14812 14811 14813 105727 16517 14814 12290 242425 14809 12287 16519 18693 12286 14395 74053 67071 14645 54393 14394 14810 12038 21912 12294 11438 14397 56808 110834 14807 14399 108015 14802 11444 54376 110886 52589 19418 14800 12300 11448 14396 55984 14401 53623 14402 16524 14408 15567 14407 16515 16522 81905 16513 14400 243547 16520 236915 14805 14806 11423 14406 381356 11669 54377 16518 16521 12846 328699 16516 14409 110637 20130 13383 231252 110902 11435 110835 11440 108043 16494 11441 100986 14610 110157 11472 14680 18750 18796 18795 18752 104110 18751 18797 110862 15481 16536 14799 224129 11513 11512 57249 11515 11514 58802 16531 12326 72413 435726 18747 16533 18749 12296 210044 432530 104111 70530 14252 15166 17246 233067 330953 225875 15165 16534 18607 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS%REACTOME DATABASE ID RELEASE 57%111367 SLBP independent Processing of Histone Pre-mRNAs 68092 116748 384091 433702 243963 67332 20638 72290 666609 DEPOLARIZATION OF THE PRESYNAPTIC TERMINAL TRIGGERS THE OPENING OF CALCIUM CHANNELS%REACTOME%R-HSA-112308.1 Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels 12296 12286 12295 12297 12298 12294 56808 12290 381356 12287 54377 12300 DEUBIQUITINATION%REACTOME%R-HSA-5688426.1 Deubiquitination 18519 66313 54644 228607 216799 170707 74112 11555 70527 22632 11835 77125 56207 101565 22030 74256 110616 107607 53376 229603 30941 22258 192656 19766 21929 22217 233875 217069 436004 224836 225280 17127 14462 231130 71586 76630 407786 83563 69641 230073 22334 319651 12021 319181 19186 19188 216080 269523 235323 70681 57296 100756 67151 12189 17248 22335 19185 66998 53380 17463 110962 382522 69077 210766 22059 327799 19358 74493 59040 19359 30940 20184 246103 107986 107260 15925 68837 269582 56456 257632 320713 22224 100683 360216 84092 70020 170822 72607 59029 319183 170711 19184 19179 22190 20422 319182 26409 319178 667035 319186 19182 319190 12427 19181 23997 66997 19671 22034 76800 66513 228769 319162 70247 67089 56208 21762 23996 71954 21951 107976 68251 54601 18002 73902 56324 107995 218214 12530 252870 319188 78303 12428 14479 68149 22225 75302 216869 109689 108155 66413 19192 226418 26445 68142 19166 84585 26444 26446 17425 26443 71956 22230 216185 20844 22223 50933 27401 54198 50868 15161 22123 57783 17131 328572 11848 15251 56505 227195 109359 21803 16913 21813 19175 21812 19177 17869 19170 103554 59025 16912 11789 17125 17128 217057 19173 17126 19172 12005 66124 15239 18035 19167 16151 26441 74996 19171 26442 319169 26440 235134 621893 228790 22031 216825 11797 56249 319189 235441 56436 11796 109275 68031 12638 101206 319176 14232 18970 319173 108645 24110 414084 50873 100043869 74270 71472 67561 68350 15267 11461 69714 71599 28185 14534 22333 319163 13982 319168 66889 319167 22284 20439 12006 104416 17246 19211 236733 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA%REACTOME%R-HSA-159227.1 Transport of the SLBP independent Mature mRNA 218210 66679 18226 69912 227720 54563 223921 103468 70699 72787 13684 53319 269113 231042 234865 69736 19069 107939 170762 59015 68092 227699 18141 433702 445007 108989 19386 21681 69482 71805 DETOXIFICATION OF REACTIVE OXYGEN SPECIES%REACTOME%R-HSA-3299685.3 Detoxification of Reactive Oxygen Species 22166 14778 18453 13057 56551 20656 11927 20657 50490 11758 11757 67305 14780 13058 75512 66401 11833 21672 26462 12460 69590 667310 14776 670717 50527 50493 11977 14775 18477 12359 CLASSICAL ANTIBODY-MEDIATED COMPLEMENT ACTIVATION%REACTOME DATABASE ID RELEASE 57%173623 Classical antibody-mediated complement activation 12260 667277 317677 12944 12259 12262 METABOLISM OF VITAMINS AND COFACTORS%REACTOME%R-HSA-196854.2 Metabolism of vitamins and cofactors 100705 109791 665563 14734 110948 216188 110821 109754 68453 72039 109672 66904 54338 330064 68421 109136 26363 78038 105663 100039707 11603 93835 65969 11806 11808 116914 29807 19225 238055 11807 17252 14735 69060 17250 19141 22072 270685 20509 16956 20522 52466 11814 108037 77697 17769 66473 67618 108156 107747 76701 19300 16835 17768 11816 69906 11433 83702 14725 21452 71951 18563 23888 68214 16971 14873 14733 54391 18605 69698 319945 72621 54219 103978 109129 238505 67096 210009 59027 246703 14603 67375 14104 69568 27973 78914 71707 66454 11813 67993 226518 192185 223646 74080 269614 106564 19223 68591 268566 74450 73132 69372 71743 17434 75735 211347 66812 77337 105349 107476 13124 665270 19659 63857 65107 13081 79235 67861 244209 20425 55938 20971 20969 19662 19660 13115 239393 170752 14473 15530 17850 22139 20525 11761 216134 13361 103711 20527 20970 15529 PLCG1 EVENTS IN ERBB2 SIGNALING%REACTOME%R-HSA-1251932.3 PLCG1 events in ERBB2 signaling 13866 13649 13645 18803 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS%REACTOME%R-HSA-73817.2 Purine ribonucleoside monophosphate biosynthesis 108147 14450 67054 23917 11564 76429 100042069 231327 229363 237823 11566 11565 HYDROLYSIS OF LPC%REACTOME DATABASE ID RELEASE 57%1483115 Hydrolysis of LPC 232889 78390 18783 74182 329502 271844 66857 NCAM1 INTERACTIONS%REACTOME%R-HSA-419037.1 NCAM1 interactions 12827 12289 14588 12295 12829 12297 19197 12839 20452 18188 12298 12830 12835 14573 12833 11603 12828 12826 14585 17967 14586 12840 11876 12296 58226 12291 12288 12834 20450 19122 245026 239556 21367 12841 12292 13004 CONDENSATION OF PROMETAPHASE CHROMOSOMES%REACTOME DATABASE ID RELEASE 57%2514853 Condensation of Prometaphase Chromosomes 13000 12534 100039026 14211 68298 13001 12442 215387 70099 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION%REACTOME DATABASE ID RELEASE 57%888590 GABA synthesis, release, reuptake and degradation 22348 12889 22318 268860 15481 19339 14415 13002 14417 20907 20614 214579 243616 14411 14412 232333 20979 HEDGEHOG LIGAND BIOGENESIS%REACTOME%R-HSA-5358346.1 Hedgehog ligand biogenesis 13363 11491 66753 20423 103978 16147 18453 77583 214240 19186 19188 269523 57296 67151 66413 19185 66998 53380 19192 20338 26445 17463 19166 69077 26444 116891 26446 216440 26443 226861 22123 59029 19184 19179 22190 20422 667035 19182 19181 23997 66997 74126 16913 228769 70247 19175 67089 19177 19170 21762 23996 103554 16912 19173 19172 73902 19167 26441 19171 26442 26440 SIGNALING BY NOTCH2%REACTOME%R-HSA-1980145.2 Signaling by NOTCH2 11487 328572 22190 18011 667035 333639 59287 54485 13388 16450 12805 16449 433586 103806 225164 270118 15208 240055 208117 15205 12912 76580 19165 100039623 19664 14128 17242 100042305 18129 14939 CYTOSOLIC TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 57%379716 Cytosolic tRNA aminoacylation 70223 22321 15115 234734 110960 353172 67895 27267 22375 104458 226414 85305 23874 107045 66143 97541 13722 66590 20226 231872 107508 107271 216443 105148 HDACS DEACETYLATE HISTONES%REACTOME%R-HSA-3214815.2 HDACs deacetylate histones 100041953 621893 107932 319181 50724 234366 216848 319189 15353 23942 382522 319176 170787 319173 433759 15182 70315 56310 94246 19712 107392 238247 99982 60406 15077 319149 245688 229542 116870 15267 319183 20185 19646 20602 319182 319178 319186 81004 319190 319163 319168 319162 21372 15183 319167 217864 71954 17192 116871 319188 78303 319169 TNF SIGNALING%REACTOME DATABASE ID RELEASE 57%75893 TNF signaling 22030 74256 53376 229603 30941 11491 14082 22190 21937 26409 21926 667035 22258 12370 11797 71609 19766 21929 76686 432940 68652 11796 66724 66513 20598 52440 24105 268749 22029 66552 73218 67384 106025 58994 12675 16151 16150 18201 14694 11798 EXTRACELLULAR MATRIX ORGANIZATION%REACTOME%R-HSA-1474244.1 Extracellular matrix organization 329941 12827 12829 12839 94216 18542 94352 12830 12832 12835 16950 12833 12831 11603 12837 12828 67573 12826 59287 12361 13038 22072 213945 18452 12505 269132 26433 69700 56401 13040 210530 12406 73368 56693 19035 30806 234407 76477 18822 23794 18189 373864 12824 71355 12476 12815 53867 12814 12813 213119 16948 16949 104099 16416 16402 14161 17967 109700 13004 12111 216725 11504 13179 56213 16421 12818 21892 24087 13003 12335 12333 17385 16408 12032 12334 13039 15894 17390 78369 83995 12339 17392 12156 12823 240047 17384 17391 14173 17393 13030 17394 17395 110135 16401 22329 16409 22370 16399 16414 12836 15896 12215 15898 18787 72902 140709 19164 12816 16621 18550 30800 13138 50817 237759 77018 18453 12822 73647 11502 12817 18073 12153 14268 19280 381924 17229 319480 21858 18074 381122 666279 23993 271127 12845 17381 15891 17386 12950 170725 208936 17180 21857 21960 58223 17183 17228 66695 23948 20692 329278 17389 13035 17387 71753 72947 12821 232345 12819 12842 107581 11501 23830 12825 13033 69543 17388 12380 330119 66473 240913 50701 12337 12338 12336 268958 11490 216760 16420 17150 21808 12154 16998 14115 100034361 58859 12159 12162 320910 21825 76293 216616 241226 13717 268977 14118 16404 14563 21803 16407 50530 81877 108075 17182 14114 14119 13406 21809 18198 16997 228357 99571 23876 18613 16456 18591 18750 11487 11491 16542 14264 17022 26432 320452 18451 14789 12367 20971 67374 20750 16772 20969 16777 12843 60409 18810 16423 16400 12550 12840 15530 16774 109711 12305 22139 12834 16403 16398 18590 245026 237360 12841 16773 20970 226519 16782 16780 16419 16776 16411 18815 15529 83964 16775 16779 13405 18214 23928 192897 16412 57764 16410 21923 CELL JUNCTION ORGANIZATION%REACTOME%R-HSA-446728.1 Cell junction organization 18759 12821 22323 56513 16480 12557 12737 12554 11727 56173 12738 71908 12388 19303 12560 239857 12565 114141 54420 12552 12740 53624 21754 320873 57342 12555 225341 241201 68794 74202 12558 20163 16202 170736 18810 12561 218952 12550 56217 192176 56863 12385 16774 109711 94332 73341 58235 16403 12741 93742 239096 75677 56492 58998 12739 12564 71740 58187 242653 93737 16782 12695 16780 239931 12476 19294 12562 18417 12563 58220 224912 54419 60363 54725 192897 16412 16456 621628 64945 215654 SYNTHESIS OF PE%REACTOME%R-HSA-1483213.3 Synthesis of PE 75320 28042 64899 237928 12651 64898 68671 320951 71760 12660 99712 14245 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION%REACTOME%R-HSA-400042.1 Adrenaline,noradrenaline inhibits insulin secretion 12289 12297 224129 11512 14706 14696 14678 14677 14688 14708 14693 14709 14697 14699 66066 12296 14700 14701 12288 14695 14704 11551 14702 14710 11553 64337 56808 GSD XV%REACTOME DATABASE ID RELEASE 57%3814836 GSD XV 27357 14936 MITOCHONDRIAL PROTEIN IMPORT%REACTOME DATABASE ID RELEASE 57%1268020 Mitochondrial protein import 14356 30055 11740 100042179 30057 30059 66821 15510 100900 68033 12856 56322 72170 67105 17714 11692 73078 66865 66119 223696 30058 100043869 17827 68653 100039174 17713 15526 66826 21856 78830 66525 636544 21855 50799 53333 28185 22333 66169 71883 15929 11946 11947 433806 67713 14297 11739 52815 30056 11429 100041835 12974 53375 66445 DOPAMINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 57%212676 Dopamine Neurotransmitter Release Cycle 12889 22318 68507 327814 22342 20964 19339 214084 22249 319924 233977 27204 20907 20614 20965 22343 108030 20979 12361 CONSTITUTIVE SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME DATABASE ID RELEASE 57%2660826 Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant 54485 11487 13388 16450 16449 11491 18128 EXTRINSIC PATHWAY OF FIBRIN CLOT FORMATION%REACTOME DATABASE ID RELEASE 57%140834 Extrinsic Pathway of Fibrin Clot Formation 14068 14058 14071 14066 21788 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21%REACTOME%R-HSA-187577.3 SCF(Skp2)-mediated degradation of p27 p21 19186 19188 57296 67151 66413 19185 66998 53380 19192 26445 17463 19166 69077 12576 26444 12448 26446 26965 26443 12575 12566 27401 22123 59029 20459 19184 19179 22190 20422 667035 19182 12427 19181 23997 66997 21402 12567 16913 12447 12443 228769 70247 19175 67089 19177 19170 54124 21762 23996 16912 19173 19172 19167 26441 19171 26442 26440 12428 G ALPHA (I) SIGNALLING EVENTS%REACTOME%R-HSA-418594.2 G alpha (i) signalling events 19739 12772 140795 14706 24012 14678 14696 14677 14679 70839 74191 57385 14688 12458 14708 14693 14709 574402 14697 242851 19218 14764 11820 14699 66066 14700 14701 14695 14704 14702 14710 64337 11552 64214 381073 71729 353165 17773 244701 23919 15199 56066 12273 239336 109648 15139 12374 20315 11609 387512 15945 18386 12266 94226 12267 20609 14427 57253 18389 14429 14428 14293 16952 387347 20608 55985 574417 208990 14289 14294 110168 20297 18166 20210 14419 387355 18155 20304 30878 387356 20604 216749 56470 57349 14745 56744 242093 13610 12801 13609 67865 353148 19737 12802 387353 66102 12769 387515 13611 385643 387348 19734 108068 53978 246709 268934 239283 226304 99296 12766 12062 225192 18387 80901 14767 12777 56183 12061 20605 433292 20311 20300 23796 50779 50782 20607 207911 14685 14686 14687 242425 54393 18167 76854 12767 58175 18168 12854 56838 227288 240816 12765 14739 217212 381810 227326 18610 330122 14823 624910 18390 67839 19065 19064 12774 18619 100038965 20606 100039973 110312 51791 387513 65086 17329 387349 57254 387342 626596 12145 108073 108069 84112 19736 14825 387616 50778 12775 12776 20310 12778 12768 67792 12771 12773 104110 15563 14539 12057 13603 15550 353344 20132 15552 57811 15551 11606 15557 11551 11553 13489 12672 13490 13491 212541 224129 11513 243764 212108 11512 11515 11514 243270 80885 18976 210044 432530 104111 11539 11542 DEGRADATION OF CYSTEINE AND HOMOCYSTEINE%REACTOME DATABASE ID RELEASE 57%1614558 Degradation of cysteine and homocysteine 211488 12583 211389 66071 27376 246277 59010 107869 22117 MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS%REACTOME%R-HSA-174490.1 Membrane binding and targetting of GAG proteins 52348 194309 66914 18108 330192 22088 22190 107305 667035 METALLOPROTEASE DUBS%REACTOME DATABASE ID RELEASE 57%5689901 Metalloprotease DUBs 18519 15267 59029 12021 621893 328572 22190 667035 70681 109359 12189 319163 216799 319168 319162 319167 319176 70527 210766 319173 107976 68251 20184 20844 320713 76630 319169 METABOLISM OF NITRIC OXIDE%REACTOME%R-HSA-202131.1 Metabolism of nitric oxide 73178 320415 51793 640703 114886 18127 20751 13361 66394 68268 13430 69219 18777 15519 19286 12389 14528 11651 329416 19092 LIGAND-INDEPENDENT CASPASE ACTIVATION VIA DCC%REACTOME%R-HSA-418889.1 Ligand-independent caspase activation via DCC 13176 13143 12367 72993 13144 107448 94275 12371 69635 107449 NICD TRAFFICS TO NUCLEUS%REACTOME DATABASE ID RELEASE 57%157052 NICD traffics to nucleus 18519 270118 19664 12914 14534 433586 18131 18129 333639 18128 103806 18132 LAMININ INTERACTIONS%REACTOME%R-HSA-3000157.1 Laminin interactions 15530 16774 18074 16403 16398 16772 12822 16777 16773 18073 226519 109700 16782 16780 16776 16775 16779 16404 23928 16400 192897 16412 16410 PKA ACTIVATION%REACTOME%R-HSA-163615.1 PKA activation 19088 18749 210044 432530 224129 11513 11512 104111 640703 11515 11514 104110 19087 19085 19084 18747 TRANSPORT OF CONNEXINS ALONG THE SECRETORY PATHWAY%REACTOME DATABASE ID RELEASE 57%190827 Transport of connexins along the secretory pathway 14609 14618 14619 MITOTIC PROMETAPHASE%REACTOME%R-HSA-68877.1 Mitotic Prometaphase 18817 26951 67629 69928 70099 11799 236930 68014 18472 208628 57294 68298 13589 52696 76707 67849 67733 83815 102920 76464 218914 66570 83431 13000 100039026 108911 76499 18221 12617 19047 215387 75786 26886 66934 19052 19053 73699 51792 73804 21770 26932 226849 26931 225849 103573 229841 69912 16563 12237 103468 56150 234865 69736 52276 13006 19357 20877 59015 12534 20842 16319 445007 12442 19386 110379 320394 226747 66442 12615 72155 108000 14211 12236 13001 60411 625534 232987 66468 67052 52504 67139 71521 70385 71876 73470 100710 70454 24061 17120 20843 228421 244495 107995 381318 66336 67037 216965 72415 56430 66977 12235 BETA OXIDATION OF BUTANOYL-COA TO ACETYL-COA%REACTOME%R-HSA-77352.1 Beta oxidation of butanoyl-CoA to acetyl-CoA 15107 93747 11409 TRANSFER OF LPS FROM LBP CARRIER TO CD14%REACTOME DATABASE ID RELEASE 57%166020 Transfer of LPS from LBP carrier to CD14 12475 16803 SIGNALING BY PLASMA MEMBRANE FGFR1 FUSIONS%REACTOME%R-HSA-8853336.1 Signaling by plasma membrane FGFR1 fusions 67384 14182 244373 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS%REACTOME%R-HSA-174143.1 APC C-mediated degradation of cell cycle proteins 66156 52206 668450 18817 12237 22194 19186 19188 56150 75430 216080 57296 67151 66413 19185 66998 53380 52717 19192 20878 26445 17463 19166 69077 26444 12234 26446 26443 26965 52563 99152 18005 229776 20877 12534 12566 27401 69957 68999 68612 17222 22123 59029 19184 19179 22190 12236 20422 667035 56371 19182 12427 19181 23997 66997 21402 16913 228769 19175 70247 19177 67089 19170 21762 23996 103554 16912 19173 19172 67141 59008 56317 73902 19167 26441 107995 19171 217232 26442 26440 30939 12428 SEPARATION OF SISTER CHROMATIDS%REACTOME%R-HSA-2467813.1 Separation of Sister Chromatids 18817 67629 26951 69928 105988 66413 19192 26445 19166 11799 236930 68014 26444 18472 26446 208628 57294 26443 13589 52696 67849 76707 67733 83815 102920 76464 218914 66570 83431 108911 76499 18221 12617 19047 75786 26886 66934 22123 19052 19053 73699 16913 19175 19177 51792 19170 103554 16912 19173 73804 21770 19172 26932 226849 26931 103573 225849 19167 26441 19171 229841 26442 26440 66156 69912 16563 52206 668450 12237 22194 19186 103468 19188 56150 75430 216080 57296 67151 19185 66998 53380 52717 17463 234865 69736 69077 52276 13006 52563 99152 19357 59015 20877 20842 16319 445007 69957 68999 19386 68612 17222 110379 320394 226747 66442 12615 59029 72155 108000 19184 12236 22190 19179 60411 20422 625534 667035 232987 19182 66468 19181 67052 52504 23997 66997 67139 71521 228769 70385 70247 71876 67089 73470 100710 21762 70454 23996 24061 17120 20843 59008 228421 56317 73902 244495 107995 381318 66336 217232 67037 216965 72415 56430 30939 66977 12235 TERMINAL PATHWAY OF COMPLEMENT%REACTOME%R-HSA-166665.2 Terminal pathway of complement 69379 12759 110382 12279 230558 12274 109828 15139 FORMATION OF THE EDITOSOME%REACTOME%R-HSA-75094.1 Formation of the Editosome 69865 11810 NUCLEOTIDE EXCISION REPAIR%REACTOME%R-HSA-5696398.1 Nucleotide Excision Repair 72584 18973 19687 69263 67967 19718 99375 108679 18972 13194 18538 19891 66467 69745 68240 18971 14884 26370 68142 27015 22632 12572 17420 59001 72151 106344 66979 18974 56438 68275 26895 22594 328572 56505 66983 71101 71991 16882 227195 233875 26754 100043429 26893 93765 67439 22591 66671 57905 225280 23894 13871 13872 209357 11834 14885 56469 13716 21399 28000 67710 235134 17749 66420 245841 56249 70620 20021 69241 109275 26891 56031 20610 100043806 319955 11545 16881 11546 19358 19359 12848 107986 69833 56456 20022 69920 231329 100043714 70020 20020 22190 11461 69714 93836 667035 229615 26894 22196 22592 50505 13870 68058 22590 77593 26572 252870 DEFECTIVE SLCO1B3 CAUSES HYPERBILIRUBINEMIA, ROTOR TYPE (HBLRR)%REACTOME DATABASE ID RELEASE 57%5619058 Defective SLCO1B3 causes hyperbilirubinemia, Rotor type (HBLRR) 11657 CALNEXIN CALRETICULIN CYCLE%REACTOME DATABASE ID RELEASE 57%901042 Calnexin calreticulin cycle 193670 54197 14827 223455 116891 320011 216440 22190 667035 75841 12330 74126 23802 66435 12317 108687 192193 19089 20338 22644 66597 227619 66967 14376 E2F-ENABLED INHIBITION OF PRE-REPLICATION COMPLEX FORMATION%REACTOME DATABASE ID RELEASE 57%113507 E2F-enabled inhibition of pre-replication complex formation 12534 56452 12530 66634 18392 26428 50793 18393 26429 PROCESSING OF DNA DOUBLE-STRAND BREAK ENDS%REACTOME DATABASE ID RELEASE 57%5693607 Processing of DNA double-strand break ends 17535 69263 12021 19718 319181 19891 68240 70620 15204 70681 240087 12189 11920 231724 382522 237911 70238 210766 327762 27223 21975 19355 20184 19367 72151 106344 12566 269582 59004 22427 68275 19356 12144 235559 319183 22190 319182 319178 667035 319186 319190 12427 107823 100043429 93765 22196 19360 235610 107976 319152 68251 81601 225182 27354 15574 19822 319188 232314 15270 12649 26909 56420 78303 66131 21853 12428 50721 PRE-NOTCH PROCESSING IN THE ENDOPLASMIC RETICULUM%REACTOME%R-HSA-1912399.2 Pre-NOTCH Processing in the Endoplasmic Reticulum 140484 18131 18129 18128 18132 224143 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S%REACTOME DATABASE ID RELEASE 57%72662 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S 13665 20115 57294 667739 27370 100038875 208643 66481 100040298 18458 67097 66235 633683 667035 55944 16785 13669 100039316 27979 267019 68135 66085 26905 22384 53356 56347 13684 67204 223691 382492 13682 20055 73830 16341 100042807 13681 54709 75705 98221 20044 668144 670832 629957 225058 75617 667279 76846 27050 13685 20102 67941 27207 668668 20103 20085 20084 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX)%REACTOME DATABASE ID RELEASE 57%2142691 Synthesis of Leukotrienes (LT) and Eoxins (EX) 11690 106648 100040843 17001 11689 72054 23887 17164 17250 11687 16993 13479 71854 319446 13120 67103 320997 14598 631304 13118 208285 DEFECTS IN BIOTIN (BTN) METABOLISM%REACTOME DATABASE ID RELEASE 57%3323169 Defects in biotin (Btn) metabolism 100705 110821 72039 66904 78038 107476 18563 SIGNALING BY NOTCH1 IN CANCER%REACTOME DATABASE ID RELEASE 57%2644603 Signaling by NOTCH1 in Cancer 18519 11487 56233 11491 333639 59287 54485 13388 16450 16449 433586 103806 79221 170787 225164 208727 15208 240055 433759 15205 26965 15213 15182 76580 15185 232232 70315 56198 15214 264064 15184 56438 12914 20185 328572 20602 22190 18011 667035 81004 14534 21402 21372 17869 15183 51813 270118 208117 19165 19664 100039623 100042305 18128 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE%REACTOME DATABASE ID RELEASE 57%3359478 Defective MUT causes methylmalonic aciduria mut type 17850 109136 ADENYLATE CYCLASE ACTIVATING PATHWAY%REACTOME DATABASE ID RELEASE 57%170660 Adenylate cyclase activating pathway 210044 224129 432530 11513 11512 104111 11515 11514 104110 14680 NEGATIVE REGULATION OF TCF-DEPENDENT SIGNALING BY DVL-INTERACTING PROTEINS%REACTOME%R-HSA-5368598.2 Negative regulation of TCF-dependent signaling by DVL-interacting proteins 13543 13542 68339 13544 319478 SIGNALING BY ERBB4%REACTOME%R-HSA-1236394.1 Signaling by ERBB4 59287 14600 19116 56438 26395 67603 319520 20203 235584 26403 16416 12223 54519 100042150 21894 11600 19060 19186 19188 20315 327826 17169 194231 109905 14161 226525 57296 67151 215449 18710 19185 66998 53380 14172 17967 15461 17463 83409 69077 29875 12234 12912 26417 26413 80707 12323 108058 12322 18015 59029 20185 19197 19417 19184 19179 22190 20422 171463 667035 14573 19182 16590 240057 19181 64654 231474 14173 80903 14164 23997 66997 68652 18039 218397 110135 14585 14178 80857 228769 14180 70247 67089 14586 14587 14175 21762 14177 23996 20416 11876 14165 20851 26554 18596 20850 109880 16399 54153 18708 15200 640703 18706 18673 12325 16818 16706 69601 83379 22371 73902 233046 114716 12981 19415 63953 14174 14580 12982 19252 16653 12991 12984 240672 13537 12988 67836 16186 13385 14588 211323 16184 18667 11836 18188 20740 20739 13645 16185 16452 216869 109689 18176 72399 70686 114715 240168 14268 66413 211255 18183 14083 16451 19192 16453 26445 19166 18218 12576 14812 76089 26444 26446 14811 26965 26443 14813 19414 80297 14814 12575 74769 16183 20742 18707 18709 20741 21687 20743 16367 13866 14810 16192 26396 14360 16191 216148 114713 14186 19418 22123 20662 19052 14170 19053 19262 73699 640524 21402 16913 75590 19175 19177 51792 19713 19170 22330 99571 13874 103554 16912 54401 83961 56637 16188 19173 19172 21770 107971 26932 100986 226849 18611 23980 20418 22601 26931 320484 225849 384783 12675 245684 67112 110157 19167 26441 19419 11472 19171 545987 13649 70727 18595 26442 26440 101809 18591 16334 76850 236511 11491 19247 16337 19109 75778 15370 12519 12524 17999 606496 107568 244650 12015 56717 22084 77647 239528 12371 98432 117150 56458 56484 213988 11652 18717 16396 12478 11651 13982 15937 78757 228775 12487 217351 208117 233833 23797 67605 18720 17246 56716 18719 214150 108083 19165 18607 100039623 14388 100042305 22324 19211 227743 18718 109270 17454 58988 DISEASES ASSOCIATED WITH THE TLR SIGNALING CASCADE%REACTOME%R-HSA-5602358.1 Diseases associated with the TLR signaling cascade 266632 106759 12475 142980 117149 22031 17874 12675 12491 19697 21899 18033 18036 18035 17087 16151 12229 18034 16150 24088 53791 21897 21898 SODIUM-COUPLED SULPHATE, DI- AND TRI-CARBOXYLATE TRANSPORTERS%REACTOME DATABASE ID RELEASE 57%433137 Sodium-coupled sulphate, di- and tri-carboxylate transporters 243755 20500 237831 114644 55961 GABA RECEPTOR ACTIVATION%REACTOME DATABASE ID RELEASE 57%977443 GABA receptor activation 104110 14706 14678 14677 14679 14688 14708 14693 14709 16517 242425 16519 14395 54393 14394 242851 14397 14399 110886 14396 14401 14402 16524 14408 14407 16515 224129 16522 16513 14400 11513 11512 16520 236915 11515 57249 11514 14406 16518 16521 328699 16516 14409 14699 14700 14701 210044 432530 14695 104111 14704 14702 14710 14680 LOSS OF NLP FROM MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 57%380259 Loss of Nlp from mitotic centrosomes 19088 76816 18817 56455 76478 71909 219072 214552 237222 20873 18536 104318 22145 73738 26370 74470 219103 17997 99100 74360 68121 18472 27373 12009 13589 54130 76707 230376 22628 66296 236266 78887 18005 15519 381644 22154 225745 12534 214444 28135 231123 13427 13424 83922 208518 75786 18541 103733 101565 78177 69654 22153 225659 227613 16328 53598 22142 68475 22627 51792 18747 100986 75296 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE%REACTOME DATABASE ID RELEASE 57%3359467 Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE 238505 210009 STRIATED MUSCLE CONTRACTION%REACTOME%R-HSA-390522.1 Striated Muscle Contraction 17883 21916 17885 21393 50876 50875 11474 50874 22004 22138 17901 17906 17897 109272 22352 17868 233199 59069 21952 21955 21954 13346 21956 11472 17896 13405 17888 21924 21953 17996 21925 21957 MRNA CAPPING%REACTOME DATABASE ID RELEASE 57%72086 mRNA Capping 67897 67710 24018 17749 66420 245841 66467 20021 69241 20924 14884 66671 23894 12572 17420 13871 13872 68092 209357 69833 14885 433702 68705 20022 69920 231329 98053 100043714 20020 TAT-MEDIATED ELONGATION OF THE HIV-1 TRANSCRIPT%REACTOME%R-HSA-167246.1 Tat-mediated elongation of the HIV-1 transcript 107951 67710 17749 66420 114741 245841 24116 66467 20021 20833 69241 20924 20922 14884 66671 23894 57314 27632 12572 17420 13871 13872 58202 209357 68092 69833 14885 13716 68705 433702 20022 67655 69920 231329 98053 67923 27224 100043714 20020 12455 21399 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION%REACTOME%R-HSA-399955.1 SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion 18186 243743 18846 18845 19353 227377 21894 20346 18717 20130 14360 223881 14159 18844 NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY%REACTOME%R-HSA-168333.1 NEP NS2 Interacts with the Cellular Export Machinery 218210 66679 18226 69912 227720 54563 223921 103468 70699 72787 269113 231042 234865 69736 19069 107939 170762 103573 59015 227699 18141 445007 108989 19386 19384 69482 71805 GALACTOSE CATABOLISM%REACTOME DATABASE ID RELEASE 57%70370 Galactose catabolism 66681 72157 74246 14635 14430 REGULATION OF TP53 ACTIVITY THROUGH METHYLATION%REACTOME%R-HSA-6804760.1 Regulation of TP53 Activity through Methylation 77683 110147 328572 22059 219022 22190 67956 667035 17246 226830 50883 57748 27374 17248 11920 241764 ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME%R-HSA-264642.1 Acetylcholine Neurotransmitter Release Cycle 12889 22318 20508 327814 68507 19339 22249 63993 233977 20907 20614 20979 12647 HSF1 ACTIVATION%REACTOME%R-HSA-3371511.1 HSF1 activation 15499 15516 68196 68275 15185 22627 19891 100043508 68240 15519 269523 DEGRADATION OF AXIN%REACTOME DATABASE ID RELEASE 57%4641257 Degradation of AXIN 66313 19186 19188 57296 67151 66413 19185 66998 53380 68031 19192 17463 26445 19166 69077 26444 26446 26443 74493 22123 59029 19184 22190 19179 20422 667035 19182 19181 23997 66997 16913 228769 19175 70247 67089 19177 19170 21762 23996 103554 16912 21951 19173 19172 12006 12005 73902 19167 26441 19171 26442 26440 GLYCOLYSIS%REACTOME%R-HSA-70171.3 Glycolysis 230163 14447 14751 11674 19052 19053 73699 18663 103988 51792 13806 18639 100043349 18640 170768 13807 13808 21770 18642 270198 18641 56421 21991 18655 15275 15277 11676 18648 56012 212032 DEFECTIVE POMGNT1 CAUSES MDDGA3, MDDGB3 AND MDDGC3%REACTOME%R-HSA-5083628.1 Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3 13138 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE%REACTOME%R-HSA-168164.1 Toll Like Receptor 3 (TLR3) Cascade 19247 22031 11797 100041766 216080 66105 19094 11796 54131 11596 110651 12475 20210 12234 21353 17164 72349 26965 20111 56489 12912 26400 26417 26413 23939 20112 257632 26420 107607 56480 11909 16476 54123 17260 13712 434174 14082 22190 26414 108960 26395 26409 667035 26398 12370 26397 192656 19766 17874 67603 19052 100040260 19053 319520 73699 26419 68652 11820 21402 66724 102626 22034 20203 66513 17258 93765 51792 103583 21898 106759 26416 142980 225471 56532 21770 12675 19697 18033 26399 18036 231130 18035 17087 16151 18034 73086 16150 13211 66589 14281 26410 235584 16179 HISTIDINE CATABOLISM%REACTOME%R-HSA-70921.2 Histidine catabolism 14317 140483 71761 243537 15109 107239 15186 BETA OXIDATION OF LAUROYL-COA TO DECANOYL-COA-COA%REACTOME DATABASE ID RELEASE 57%77310 Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA 15107 93747 231086 97212 11363 PLATELET AGGREGATION (PLUG FORMATION)%REACTOME DATABASE ID RELEASE 57%76009 Platelet Aggregation (Plug Formation) 16416 54519 12927 20963 21894 54368 14723 14729 14724 109905 20662 14161 223864 215449 14268 110135 12928 11651 14083 19395 14061 56508 99571 20416 16399 11551 11553 22371 18607 19419 17480 21832 11552 12988 19246 PORPHYRIN METABOLISM%REACTOME%R-HSA-189445.1 Porphyrin metabolism 22276 233016 14151 70383 19044 109778 11655 11656 394436 15368 15369 15288 22275 12892 17025 394433 226139 ACTIVATION OF BID AND TRANSLOCATION TO MITOCHONDRIA%REACTOME DATABASE ID RELEASE 57%75108 Activation of BID and translocation to mitochondria 18107 12122 12370 14939 CLEARANCE OF SERATONIN%REACTOME%R-HSA-380615.2 Clearance of seratonin 17161 15567 11669 PHYSIOLOGICAL FACTORS%REACTOME DATABASE ID RELEASE 57%5578768 Physiological factors 18519 14463 230103 18160 18091 18159 21388 97064 230899 53419 15257 15258 G BETA:GAMMA SIGNALLING THROUGH PLC BETA%REACTOME DATABASE ID RELEASE 57%418217 G beta:gamma signalling through PLC beta 14699 18796 66066 14700 18795 14701 14695 14704 14702 14710 64337 14706 14696 14688 14708 18797 14693 14709 14697 POTASSIUM CHANNELS%REACTOME%R-HSA-1296071.1 Potassium Channels 14706 52150 16530 84036 16525 14688 140492 14708 140493 14693 14709 56379 15168 16517 72258 16528 242425 16526 16519 211468 54393 241794 67498 223604 238271 16524 16510 192775 16515 16499 16522 16504 382571 16513 16490 16492 16520 240595 16491 226922 225030 66733 16527 16485 98741 16518 380728 16521 16539 16512 16516 16497 16538 99738 242151 16502 16500 170738 16493 16498 16494 268345 16495 240444 60613 238076 14699 14700 14701 16523 14695 14704 14702 14710 20927 217826 20928 332396 110862 16514 16536 211480 16508 16511 56543 16506 16535 74571 58802 16531 72413 435726 16533 15166 330953 15165 16534 EGFR TRANSACTIVATION BY GASTRIN%REACTOME DATABASE ID RELEASE 57%2179392 EGFR Transactivation by Gastrin 20662 18750 13649 15200 16653 15461 17392 18176 RESOLUTION OF SISTER CHROMATID COHESION%REACTOME%R-HSA-2500257.1 Resolution of Sister Chromatid Cohesion 69912 16563 12237 18817 67629 26951 103468 56150 69928 234865 69736 11799 236930 68014 18472 52276 208628 57294 13589 13006 52696 67849 76707 67733 83815 102920 76464 19357 218914 66570 59015 83431 20877 12534 20842 108911 76499 16319 18221 445007 12617 12442 19047 75786 19386 26886 66934 110379 320394 226747 66442 12615 72155 108000 12236 60411 625534 232987 66468 67052 19052 52504 19053 73699 67139 71521 70385 71876 51792 73470 100710 70454 24061 17120 73804 21770 20843 26932 226849 26931 103573 225849 228421 244495 107995 381318 66336 67037 216965 72415 229841 56430 66977 12235 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE%REACTOME%R-HSA-1799339.1 SRP-dependent cotranslational protein targeting to membrane 66256 67437 20832 76808 68028 100043755 66661 19899 67186 20115 217337 57294 667739 67025 27370 65019 67248 666669 100038991 100038875 100040021 56529 69019 66286 432502 66481 100040298 238217 56040 66624 667618 76687 19989 20818 13200 107513 20014 67398 57743 66212 53421 100043039 103963 67891 100042986 100042740 621100 100043295 67097 100043000 625646 67281 633683 666899 667035 16785 100039316 267019 100040970 72265 19941 382492 24067 20055 66384 19951 20813 100042670 27058 68193 665189 668182 19921 20044 668144 100043423 100043893 670832 100043876 629957 225058 22121 75617 667279 76846 27050 100043184 19934 100040331 100043391 319195 68172 241053 100043209 20102 67941 27207 668668 20103 672214 622534 20085 20084 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX%REACTOME DATABASE ID RELEASE 57%3769402 Deactivation of the beta-catenin transactivating complex 20674 20675 67087 20671 20668 17283 21888 22190 21885 20682 21886 667035 20677 67772 13016 11652 381022 11651 20679 73739 20680 80288 11789 213464 12234 433759 21414 23808 22631 16842 12387 21415 77578 103573 68911 21887 72135 21416 11798 GLYOXYLATE METABOLISM AND GLYCINE DEGRADATION%REACTOME%R-HSA-389661.4 Glyoxylate metabolism and glycine degradation 12040 12039 27402 13171 76238 70316 268782 15112 11611 623661 67164 14711 209692 70503 79464 13142 434437 68133 104174 18293 235339 78920 13382 18597 68263 ACTIVATION OF BH3-ONLY PROTEINS%REACTOME%R-HSA-114452.1 Activation of BH3-only proteins 22062 21981 12015 100039786 56455 11652 26419 11651 22627 209456 22061 55948 12122 54401 68097 23797 22059 12043 12125 22631 22629 22628 13555 21781 19058 19057 171543 ENZYMATIC DEGRADATION OF DOPAMINE BY COMT%REACTOME%R-HSA-379397.1 Enzymatic degradation of dopamine by COMT 17161 12846 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM%REACTOME%R-HSA-1638091.1 Heparan sulfate heparin (HS-GAG) metabolism 14734 15478 15476 195646 103978 17423 50787 70484 27029 64580 11603 110006 218271 328779 233781 628779 14735 280645 15531 23908 319415 83398 50785 121021 54710 117592 13004 27419 12111 29873 14043 12091 13179 545291 14042 13003 12032 20971 20969 15931 93683 15442 50786 76898 72727 71951 15932 217119 23888 15530 20970 15529 14733 TRNA MODIFICATION IN THE MITOCHONDRION%REACTOME DATABASE ID RELEASE 57%6787450 tRNA modification in the mitochondrion 15108 68291 52575 72026 66966 70359 TRAF6 MEDIATED NF-KB ACTIVATION%REACTOME DATABASE ID RELEASE 57%933542 TRAF6 mediated NF-kB activation 22030 11596 20210 434174 71956 26401 17874 12675 228607 19697 18033 18036 18035 71586 16151 18034 217069 16150 11820 22034 20203 13211 230073 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE%REACTOME%R-HSA-168181.1 Toll Like Receptor 7 8 (TLR7 8) Cascade 19094 11596 110651 20210 12234 17164 72349 26965 20111 12912 26400 26417 240518 26413 23939 20112 257632 81897 266632 26420 170743 107607 11909 54123 16476 17260 170744 13712 434174 22190 26414 108960 26395 26409 26401 667035 26398 72162 26397 192656 17874 67603 19052 100040260 19053 319520 73699 26419 68652 11820 21402 66724 102626 22034 20203 66513 17258 93765 51792 26940 103583 26416 21770 12675 19697 18033 26399 18036 231130 18035 16151 18034 73086 16150 67245 93834 13211 66589 14281 26410 235584 16179 SIGNALING BY FGFR3 FUSIONS IN CANCER%REACTOME DATABASE ID RELEASE 57%8853334 Signaling by FGFR3 fusions in cancer 20662 14184 14388 18708 18706 16653 15461 327826 18176 LYSOSOME VESICLE BIOGENESIS%REACTOME%R-HSA-432720.1 Lysosome Vesicle Biogenesis 72685 22318 17113 215890 75612 11781 68953 252903 20404 109689 11840 108011 64138 13423 67300 11820 20955 11782 14533 74325 108012 11768 22320 15481 74438 12757 11766 11769 13430 11767 15239 105245 67489 11765 11764 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC%REACTOME%R-HSA-3359474.1 Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC 67096 CLATHRIN DERIVED VESICLE BUDDING%REACTOME DATABASE ID RELEASE 57%421837 Clathrin derived vesicle budding 72685 20661 69178 14319 17113 215890 11781 252903 20404 66616 109689 108011 11840 13423 20615 216705 20955 21987 117197 20619 108012 11768 22320 15481 20909 12757 11766 67602 13430 11767 16004 18457 107338 11774 14325 232946 67489 11765 11764 80912 233489 22318 75612 68953 64138 27059 108124 67300 29816 19345 11820 67804 18704 94245 11782 22042 14533 320634 74325 74438 11769 11777 12874 15239 105245 245638 231580 77929 METABOLISM OF FOLATE AND PTERINES%REACTOME DATABASE ID RELEASE 57%196757 Metabolism of folate and pterines 665563 216188 20425 100039707 13361 270685 20509 52466 108037 17769 108156 107747 17768 69906 ION HOMEOSTASIS%REACTOME%R-HSA-5578775.1 Ion homeostasis 12323 108058 12322 56188 11931 110893 13400 229709 57780 65973 59095 20866 22063 20928 109552 18125 109305 11928 16440 20541 232975 98660 18747 11941 16438 20191 20192 21954 16514 269717 640703 12325 11932 110891 11938 53313 76757 11937 381290 320707 67972 14226 16439 20190 108017 11933 PACKAGING OF EIGHT RNA SEGMENTS%REACTOME%R-HSA-168303.1 Packaging of Eight RNA Segments G PROTEIN GATED POTASSIUM CHANNELS%REACTOME DATABASE ID RELEASE 57%1296059 G protein gated Potassium channels 14699 14700 16524 14701 16515 16522 16513 14695 16520 16517 14704 242425 14702 14710 16519 16518 16521 14706 16516 54393 14688 14708 14693 14709 KETONE BODY METABOLISM%REACTOME DATABASE ID RELEASE 57%74182 Ketone body metabolism 208982 78894 67041 15360 110446 69772 15356 71911 NADE MODULATES DEATH SIGNALLING%REACTOME DATABASE ID RELEASE 57%205025 NADE modulates death signalling 18049 12070 12367 12366 18053 22627 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS)%REACTOME DATABASE ID RELEASE 57%373076 Class A 1 (Rhodopsin-like receptors) 58182 246313 23832 319197 319430 233079 14763 229791 18217 22045 272031 217369 20312 246691 75769 20299 12772 22044 14744 140795 233080 67168 20302 78826 13051 436440 70839 252837 74191 280287 57385 12458 208188 233571 56696 235036 14063 18441 12424 18442 12209 78134 12425 574402 13618 11555 24111 18101 68039 171469 14715 114229 23925 67405 235044 16963 226278 13615 13614 58861 57260 14714 54199 20303 238377 20295 20306 107221 20296 12640 20292 50501 13616 13617 16866 623503 22439 20290 233081 14829 59289 225642 19216 19218 14764 19220 11820 14065 18429 18430 14062 11552 14064 381073 17773 244701 23919 15199 56066 239336 12273 109648 15139 20315 11609 15945 18386 94226 12266 20609 12267 14427 11607 18389 14429 14428 14293 16952 20608 21338 55985 208990 14289 14294 110168 20297 18166 20210 14419 21333 18155 20304 21334 30878 21337 20604 216749 11998 57349 14745 56744 242093 13610 12801 13609 12802 66102 21336 12769 13611 385643 53978 18216 12426 224065 13349 16995 216152 70086 239283 15466 226304 99296 12766 21390 15465 12062 225192 18387 80901 19204 14767 12777 56183 12061 20605 433292 20311 20300 23796 20607 207911 19219 14061 12000 18167 12767 76854 18168 12854 56838 227288 12765 14739 217212 381810 18610 227326 330122 18390 22094 26361 54140 19065 12774 19064 18619 100038965 20606 100039973 110312 65086 17329 14308 12145 84112 14825 12775 12776 20310 12778 12768 12771 12773 19156 213788 17200 104443 15563 230777 15562 229214 14539 237362 12057 15560 13603 15171 15550 353344 15566 30044 15565 20132 15552 57811 15551 15559 15558 11606 54615 227717 15557 387285 11551 20293 11553 13489 11548 11549 12671 11550 12669 12672 18241 13490 13491 212541 16867 319239 19214 14309 243764 212108 100043254 17202 17199 17201 17203 22095 209512 215855 16336 243270 80885 382348 18976 13492 19773 11540 11539 13488 215854 227289 111174 11541 11542 19217 381489 503558 19222 11554 11556 140498 TRIF-MEDIATED TLR3 TLR4 SIGNALING%REACTOME DATABASE ID RELEASE 57%937061 TRIF-mediated TLR3 TLR4 signaling 19247 22031 11797 100041766 216080 66105 19094 11796 54131 11596 110651 12475 20210 12234 21353 17164 72349 26965 20111 56489 12912 26400 26417 26413 23939 20112 257632 26420 107607 56480 11909 16476 54123 17260 13712 434174 14082 22190 26414 108960 26395 26409 667035 26398 12370 26397 192656 19766 17874 67603 19052 100040260 19053 319520 73699 26419 68652 11820 21402 66724 102626 22034 20203 66513 17258 93765 51792 103583 21898 106759 26416 142980 225471 56532 21770 12675 19697 18033 26399 18036 231130 18035 17087 16151 18034 73086 16150 13211 66589 14281 26410 235584 16179 CAM PATHWAY%REACTOME DATABASE ID RELEASE 57%111997 CaM pathway 18750 19088 18573 18753 224129 11513 11512 11515 18752 11514 104110 12326 110355 18747 18574 18749 210044 18575 432530 104111 640703 12912 19087 19085 19084 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL%REACTOME DATABASE ID RELEASE 57%1855183 Synthesis of IP2, IP, and Ins in the cytosol 269180 104015 71780 212111 114663 16330 16329 234515 55980 320634 REGULATION OF COMPLEMENT CASCADE%REACTOME%R-HSA-977606.2 Regulation of Complement cascade 69379 22370 110382 319430 12279 230558 12274 333883 12273 109828 12628 15139 14962 17221 19128 12266 12267 625018 12263 12630 FORMATION OF THE EARLY ELONGATION COMPLEX%REACTOME%R-HSA-113418.1 Formation of the Early Elongation Complex 67710 17749 66420 245841 24116 66467 20021 69241 20924 20922 14884 66671 23894 57314 27632 12572 17420 13871 13872 58202 209357 68092 69833 14885 433702 68705 20022 67655 69920 231329 98053 100043714 20020 CHROMOSOME MAINTENANCE%REACTOME DATABASE ID RELEASE 57%73886 Chromosome Maintenance 18973 19687 69263 67967 19718 319181 18972 18538 19891 69745 69928 68240 232440 18971 217653 70645 66578 93762 382522 319176 327762 16881 14156 67733 83815 102920 76464 66570 497652 59001 624153 21749 72151 28113 106344 101185 51788 57321 66979 18974 12617 68275 26886 245688 320394 15267 12615 319183 72155 19646 18969 19075 60411 21750 56505 319182 319178 319186 319190 52530 245474 216853 20174 52504 21752 319168 71876 319167 70454 319152 66311 20892 100038822 233532 18148 66336 319188 15270 18968 19076 319169 78303 LIPOPROTEIN METABOLISM%REACTOME DATABASE ID RELEASE 57%174824 Lipoprotein metabolism 58194 68453 18550 103161 18453 11772 11425 18553 19699 11771 93835 71770 65969 11806 11808 11812 66113 11813 11303 100102 238055 11807 13131 18552 218203 12757 232910 15450 11773 110611 232345 208677 16956 11814 14360 22359 624219 57875 30924 16835 11816 171504 56453 22259 27801 22260 67300 17777 270669 66397 100017 11307 16816 56636 18747 18749 11657 TLR3 DEFICIENCY - HSE%REACTOME DATABASE ID RELEASE 57%5602410 TLR3 deficiency - HSE 142980 COOPERATION OF PDCL (PHLP1) AND TRIC CCT IN G-PROTEIN BETA FOLDING%REACTOME DATABASE ID RELEASE 57%6814122 Cooperation of PDCL (PhLP1) and TRiC CCT in G-protein beta folding 13001 19739 14706 24012 14678 14696 14677 14679 14688 14708 14693 14709 14697 14699 12466 66066 12467 14700 12469 14701 14695 67466 12465 21454 14704 14702 12462 12461 14710 12464 64337 12468 50779 13000 100039026 50782 242851 14681 14685 14686 14687 LIGAND-DEPENDENT CASPASE ACTIVATION%REACTOME%R-HSA-140534.1 Ligand-dependent caspase activation 22030 106759 142980 12475 225471 14082 21933 14102 14103 22035 12370 71609 19766 17087 21898 RNA POLYMERASE II TRANSCRIPTION ELONGATION%REACTOME DATABASE ID RELEASE 57%75955 RNA Polymerase II Transcription Elongation 67710 17749 66420 245841 66467 20021 20833 69241 20924 20922 14884 12572 17420 68092 69833 433702 68705 20022 69920 231329 98053 100043714 20020 107951 12454 114741 24116 214498 22083 54624 235497 66671 76246 66317 23894 57314 27632 13871 13872 58202 209357 14885 13716 67655 67923 27224 72949 12455 21399 TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G2 CELL CYCLE ARREST%REACTOME%R-HSA-6804114.2 TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest 55948 211586 19651 328572 19650 13197 22059 18538 59035 12028 21781 12534 15469 12532 104394 20878 29813 TRANSCRIPTIONAL ACTIVATION OF P53 RESPONSIVE GENES%REACTOME%R-HSA-69560.1 Transcriptional activation of p53 responsive genes 59092 22059 12575 29813 LOSS OF FUNCTION OF TGFBR1 IN CANCER%REACTOME%R-HSA-3656534.1 Loss of Function of TGFBR1 in Cancer 17127 14225 17126 21803 21813 21812 GPCR LIGAND BINDING%REACTOME%R-HSA-500792.2 GPCR ligand binding 319430 13363 20423 16147 12772 20287 11517 14706 14607 14696 14526 14527 11516 14602 14688 12458 14708 14693 14709 14601 14697 19206 319757 19216 19218 14764 19220 11820 22411 14699 66066 14700 14701 14695 93896 14652 14704 14702 381853 14710 14065 64337 14062 11552 14064 12273 15139 12266 22416 12267 216795 16952 21338 22417 20210 21333 21334 21337 57349 56744 385643 21390 19204 20607 207911 19219 18167 12000 12767 76854 18168 12854 56838 227288 12765 14739 217212 381810 227326 330122 14823 22094 26361 54140 19065 12774 19064 18619 100038965 20606 100039973 110312 387513 65086 17329 387349 57254 387342 12145 14308 108073 108069 84112 14825 387616 12775 12776 20310 12778 12768 12771 12773 22415 22423 213788 17200 104443 230777 229214 14539 237362 12057 13603 15171 353344 30044 20132 57811 20890 51801 223780 11535 54615 12311 12310 227717 56089 387285 54409 22408 20293 13489 11548 11549 12671 11550 12669 12672 18241 13490 13491 16867 319239 19214 14309 243764 212108 100043254 17202 17199 17201 17203 22095 209512 215855 114640 16336 243270 80885 22410 382348 13492 19228 213527 19773 12922 11540 11539 13488 215854 12918 227289 19226 111174 11541 12921 11542 19217 19227 381489 503558 19222 11554 11556 140498 14370 58182 246313 23832 319197 14368 14365 233079 14367 14763 229791 22418 18217 22045 57265 272031 217369 20312 246691 75769 14816 20299 22044 140795 14744 67168 233080 78826 20302 108071 13051 436440 70839 74191 252837 57385 280287 233571 208188 235036 56696 18441 14063 18442 12424 78134 12209 574402 12425 11555 13618 24111 18101 68039 171469 14715 114229 23925 67405 235044 16963 226278 13615 13614 58861 57260 14714 54199 20303 238377 20295 107221 20306 12640 20296 20292 14362 50501 13616 16866 13617 623503 22439 14366 20290 233081 14369 14829 59289 225642 54598 210198 13733 22414 93735 19207 26364 22421 22422 110326 83770 22412 14371 18429 18430 22409 93897 22413 22420 83771 381073 353165 17773 244701 23919 15199 56066 239336 109648 12374 20315 11609 387512 15945 18386 94226 20609 11607 14427 57253 18389 14429 14428 14293 387347 20608 55985 574417 208990 14289 14294 110168 20297 18166 14419 387355 18155 20304 30878 387356 20604 216749 11998 14745 242093 13610 12801 13609 353148 12802 387353 21336 66102 12769 387515 13611 387348 108068 53978 268934 18216 12426 224065 13349 16995 216152 70086 239283 15466 226304 99296 12766 15465 12062 225192 18387 80901 14767 12777 56183 12061 20605 433292 20311 20300 23796 14061 242425 54393 18610 18390 19156 15563 15562 15560 15550 15566 15565 15552 15551 15559 15558 11606 15557 15874 11551 11553 212541 18976 ASPARAGINE N-LINKED GLYCOSYLATION%REACTOME DATABASE ID RELEASE 57%446203 Asparagine N-linked glycosylation 27096 235416 11842 241159 20452 67542 11839 19703 235504 75540 11840 56455 50798 77371 59288 104318 20448 109785 245828 380959 240119 225896 107652 11844 234730 17156 68947 70349 13427 12640 13424 12847 16866 56174 74498 20446 56358 69654 245847 67857 53598 213575 50935 24060 328370 108123 108124 217364 20451 213827 21802 19089 11843 12794 80286 217664 17309 207958 234663 70361 20014 22428 217615 67511 67569 102339 317717 68137 14376 233824 54161 19025 66251 269523 77038 19324 56447 21787 227697 56737 53618 24070 20703 14827 18195 53334 230815 78232 12068 19359 52036 56389 14422 57377 66111 76983 218138 66682 99683 18010 12317 54342 23956 57357 207352 67422 224139 99412 76308 89867 110119 22190 19179 13032 667035 338366 17158 192156 50877 97484 11733 11735 68563 216131 54613 243819 12836 59042 57170 105522 14275 208624 20445 13426 69064 208211 12764 66890 100042773 13135 20740 333883 20739 67311 193813 67075 320438 56386 57370 56375 53418 22242 56336 331026 69080 66789 20333 54128 29858 67231 80297 20742 20741 107338 20743 381903 67091 110350 12091 71665 228998 13200 56494 215474 50907 14595 107895 17308 69608 640524 66397 74126 214895 76332 59005 59007 52014 16430 14069 242362 338337 16834 109154 67727 14067 94181 67819 20334 16334 218811 76510 12793 56395 75841 14584 23802 269181 66435 108687 192193 26938 20338 105785 17155 22644 66597 14583 227619 66967 13191 193670 68097 54197 223455 116891 320011 54160 216440 50797 69162 13481 56041 74091 13480 14799 56418 11890 20447 66226 11889 110379 103963 102580 103534 13478 66248 227648 98388 66174 66913 64138 20454 60409 12330 228368 22122 225742 20450 67665 72978 54399 241230 100042343 20449 20442 20443 17957 20440 20444 DSCAM INTERACTIONS%REACTOME DATABASE ID RELEASE 57%376172 DSCAM interactions 13176 29857 26416 26419 19094 19353 26415 18479 18208 114873 13508 INTRA-GOLGI AND RETROGRADE GOLGI-TO-ER TRAFFIC%REACTOME%R-HSA-6811442.1 Intra-Golgi and retrograde Golgi-to-ER traffic 16581 16554 73124 209737 100042773 16565 11842 17113 69834 67542 16564 76688 26951 668303 20932 67023 11840 53330 74947 224630 56455 54214 12121 19159 59288 19158 19157 27277 20333 70218 18472 270192 70646 72318 11844 22319 17156 53357 107338 70349 13427 12847 13424 75985 110350 19348 16561 18476 69654 56358 228998 16571 56494 242406 53598 213575 109181 108123 108124 70297 213827 11843 76332 67474 16568 16570 16572 73804 224705 74764 234663 71116 22428 56382 270160 67511 110033 102339 286942 227746 76895 338337 16834 229841 16593 68137 58244 66905 16551 16563 16573 76899 233824 54161 74375 78689 66251 72772 16569 77038 19324 226089 16562 71819 28169 105785 240641 17155 68299 232943 56447 13191 16552 68097 56367 18195 18783 53334 54160 50797 230815 56389 16004 26934 66111 76932 56418 53611 104303 68505 76308 16560 16579 108148 14423 319642 73296 19330 66913 226407 232286 269152 19346 17158 78304 18475 97484 75050 73470 13047 76877 67665 11650 59042 228421 22365 54399 228960 100042343 19338 319991 16558 13426 16594 17957 245944 98910 CTLA4 INHIBITORY SIGNALING%REACTOME DATABASE ID RELEASE 57%389513 CTLA4 inhibitory signaling 17096 21770 23797 19247 26932 226849 26931 16818 225849 12519 12524 19052 19053 73699 18607 12477 11652 11651 22612 14360 51792 RAF MAP KINASE CASCADE%REACTOME%R-HSA-5673001.2 RAF MAP kinase cascade 56438 26395 67603 319520 235584 26403 16416 12223 54519 100042150 21894 11600 19060 19186 19188 327826 17169 194231 109905 14161 226525 57296 67151 215449 19185 66998 53380 14172 17967 15461 17463 83409 69077 29875 26417 26413 12323 108058 12322 18015 59029 19197 19417 19184 19179 22190 20422 171463 14573 667035 19182 16590 240057 19181 231474 64654 80903 14173 23997 14164 66997 18039 218397 110135 14585 14178 80857 228769 14180 70247 67089 14586 14587 14175 21762 14177 23996 20416 11876 14165 26554 18596 109880 16399 54153 15200 640703 18673 12325 16706 69601 83379 22371 73902 233046 114716 12981 19415 63953 14174 12982 19252 16653 12984 240672 13537 12988 67836 16186 13385 14588 211323 16184 11836 18188 20740 20739 13645 16185 16452 216869 109689 18176 72399 70686 114715 240168 14268 66413 211255 18183 14083 16451 19192 16453 26445 19166 18218 14812 76089 26444 26446 14811 26443 14813 19414 80297 14814 16183 20742 20741 21687 20743 16367 13866 14810 16192 26396 14360 16191 216148 114713 14186 19418 22123 20662 19052 14170 19053 19262 73699 640524 16913 75590 19175 19177 51792 19713 19170 22330 99571 13874 103554 16912 54401 83961 16188 19173 19172 21770 26932 107971 226849 100986 18611 23980 26931 20418 225849 320484 384783 245684 67112 110157 19167 26441 19419 11472 19171 545987 13649 70727 18595 26442 26440 101809 18591 AMINO ACID AND DERIVATIVE METABOLISM%REACTOME DATABASE ID RELEASE 57%71291 Amino acid and derivative metabolism 72039 78038 23972 23971 76808 68028 100043755 240332 19899 67186 20115 57294 667739 67025 27370 65019 67248 666669 100038991 100038875 100040021 12640 432502 66481 100040298 238217 56040 667618 19989 22173 14661 26912 30956 13166 209027 27376 72560 107869 13195 12411 70337 107272 18242 18478 270076 212647 66514 99439 21823 234724 217593 11298 13370 14719 13371 73748 19125 21743 216456 236539 12709 216343 14718 76722 110391 67092 13190 102857 13180 14431 14660 107585 12716 14085 12715 14630 18948 14629 14204 104816 14874 15445 19193 11484 66054 64918 11846 20810 212503 67870 56369 20229 18416 67873 19186 671878 19188 109900 83885 67824 227231 104923 11898 57296 67151 18408 11847 19185 66902 66998 217214 53380 17463 69077 235339 18597 68263 14317 192289 140483 27402 59029 56752 20425 170442 19184 19179 76238 20422 71761 667035 243537 19182 15109 107239 266645 15186 229905 19181 15112 98256 11611 70266 623661 209176 23997 67164 107766 66997 14711 15930 209692 70789 70503 56720 79464 23923 71562 110695 228769 70247 67089 21762 13142 12116 23996 22117 211488 12583 73902 18293 211389 66071 246277 78920 59010 13382 114479 12040 12036 12039 12035 11992 104776 13171 12041 66885 243382 58875 66948 268782 56357 227095 66413 243616 14411 110446 19192 26445 19166 26444 26446 434437 26443 68133 104174 72947 14645 22123 70316 22094 16913 75986 242669 19175 19177 19170 18263 53814 103554 16912 19173 19172 19167 26441 19171 26442 18104 26440 18247 18245 54375 15108 238505 210009 27053 269378 18113 66194 11720 235386 21990 15233 22018 12971 214593 69051 50880 76282 100678 67891 100042986 100042740 621100 100043295 67097 100043000 625646 67281 633683 666899 16785 100039316 267019 100040970 211006 19941 65967 382492 214580 20055 75420 19951 20226 100042670 68193 665189 668182 19921 20044 668144 100043423 100043893 670832 100043876 629957 225058 22121 75617 667279 76846 27050 100043184 19934 104458 100040331 226414 100043391 85305 319195 50493 107045 68172 241053 100043209 66143 20102 67941 97541 27207 13722 668668 20103 672214 231872 622534 107508 20085 216443 20084 105148 REGULATION OF GAP JUNCTION ACTIVITY%REACTOME DATABASE ID RELEASE 57%191650 Regulation of gap junction activity 14609 21872 BETA OXIDATION OF PALMITOYL-COA TO MYRISTOYL-COA%REACTOME%R-HSA-77305.1 Beta oxidation of palmitoyl-CoA to myristoyl-CoA 231086 11370 97212 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE%REACTOME%R-HSA-176408.1 Regulation of APC C activators between G1 S and early anaphase 66156 52206 668450 18817 12237 22194 19186 19188 56150 75430 216080 57296 67151 66413 19185 66998 53380 52717 19192 26445 17463 19166 69077 26444 12234 26446 26443 26965 52563 99152 12534 12566 69957 68999 68612 17222 22123 59029 19184 19179 22190 12236 20422 667035 56371 19182 12427 19181 23997 66997 21402 16913 228769 19175 70247 19177 67089 19170 21762 23996 103554 16912 19173 19172 67141 59008 56317 73902 19167 26441 107995 19171 217232 26442 26440 12428 CHAPERONIN-MEDIATED PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 57%390466 Chaperonin-mediated protein folding 545486 56612 108077 238463 73710 22143 67199 22151 18637 22147 99371 67951 22327 55946 22146 53857 109054 19739 22152 30839 66887 14706 20698 24012 14678 14696 14677 14679 213980 14688 30838 22145 14708 14693 30050 14709 14697 12466 12467 12469 12448 22059 242960 67466 50754 12465 50789 21454 12462 12461 12464 16553 12468 67134 13000 100039026 14976 242851 71833 106052 50762 22153 24128 27055 14447 227613 13001 11461 22142 216853 20848 12447 15183 14699 66066 14700 14466 14701 14695 14704 14702 14710 64337 50779 68628 50782 14681 236733 14685 14686 14687 LOSS OF FUNCTION OF TGFBR2 IN CANCER%REACTOME DATABASE ID RELEASE 57%3642278 Loss of Function of TGFBR2 in Cancer 14225 21803 21813 21812 SODIUM CALCIUM EXCHANGERS%REACTOME DATABASE ID RELEASE 57%425561 Sodium Calcium exchangers 110891 214111 238384 109552 94249 76376 110893 170756 640703 20541 317750 AUF1 (HNRNP D0) BINDS AND DESTABILIZES MRNA%REACTOME DATABASE ID RELEASE 57%450408 AUF1 (hnRNP D0) binds and destabilizes mRNA 19186 19188 57296 67151 66413 19185 66998 53380 19192 15507 17463 26445 19166 69077 26444 26446 193740 26443 15481 208643 18458 22123 59029 19184 22190 19179 20422 667035 19182 19181 23997 66997 16913 228769 19175 70247 67089 19177 19170 21762 23996 103554 16912 19173 19172 73902 19167 26441 19171 26442 26440 FRUCTOSE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 57%5652227 Fructose biosynthesis 11677 20322 TGFBR1 KD MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 57%3656532 TGFBR1 KD Mutants in Cancer 17127 14225 17126 21803 21813 21812 ACTIVATION OF RAS IN B CELLS%REACTOME%R-HSA-1169092.1 Activation of RAS in B cells 240168 19419 16653 15461 18176 TRANSLESION SYNTHESIS BY Y FAMILY DNA POLYMERASES BYPASSES LESIONS ON DNA TEMPLATE%REACTOME DATABASE ID RELEASE 57%110313 Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template 18973 19687 69263 56791 67967 19718 100038882 18972 22190 56210 18538 667035 19891 69745 68240 71890 18971 19714 269523 217069 74153 68098 244666 217365 27015 68026 80905 216835 22230 59001 72151 106344 66979 18974 22224 68275 26447 VITAMIN D (CALCIFEROL) METABOLISM%REACTOME DATABASE ID RELEASE 57%196791 Vitamin D (calciferol) metabolism 14725 13081 65969 244209 14473 19141 13115 ORGANELLE BIOGENESIS AND MAINTENANCE%REACTOME DATABASE ID RELEASE 57%1852241 Organelle biogenesis and maintenance 19889 56284 74025 56282 24030 12879 14548 67707 94061 56350 69956 106840 94067 76816 107734 18817 68611 67681 109151 28030 74600 78523 66419 60441 56280 56455 121022 17261 76478 69527 71909 66407 219072 77721 214552 66230 237222 68537 20873 67994 18536 28028 104318 64655 22145 66242 73738 68565 69163 26370 67840 74470 68735 219103 27398 17997 99100 74360 65111 68121 216767 18472 67308 27373 66047 12009 52443 13589 66163 54130 64657 76707 99045 230376 118451 66296 64656 236266 79044 78887 59054 18005 27397 66493 15519 381644 22154 225745 214444 28135 231123 13427 13424 319757 83922 208518 75786 18541 103733 101565 78177 17274 69654 22153 225659 11909 17260 227613 16328 53598 22142 68475 213575 11655 21372 22627 11843 73916 213081 81896 21821 106633 217166 15278 73668 67661 245866 216151 380718 16569 19013 19014 12912 15185 22628 12534 244585 74682 53869 20185 16579 232987 238799 67036 218506 94063 353242 64660 68499 66973 75398 107732 66223 27393 68836 67212 18120 66121 50529 66258 57312 623346 75296 232536 102060 59035 94062 64659 71492 69940 107733 52028 68463 72569 622268 76260 66845 93730 66399 216363 66077 224481 94065 20607 66292 66482 71769 233870 207911 100042811 319845 66448 67378 18100 56297 94066 102774 64658 59030 68572 241950 100040519 56406 229003 12469 211446 20336 170826 670717 53413 12465 21454 12462 18181 12461 12464 102058 107338 110350 15161 12914 109181 105504 51792 16568 108079 64436 241113 16570 26416 66993 100986 74201 67161 19088 320299 320806 226153 66061 75465 67068 73242 13196 76779 76411 232944 100041639 217335 78802 26379 654470 19017 108099 72421 140810 29857 19079 18764 12589 108097 72938 19094 329795 50776 19082 260305 77048 18763 74019 76366 68259 67694 264134 67871 68146 67286 68097 382090 71820 27078 277939 217935 69606 215445 108853 76568 76784 14390 53885 16559 17978 64384 20181 72140 67590 212541 381760 17977 67344 107371 81004 15183 18747 208595 21780 11947 233649 67042 231214 52906 226169 18000 109242 67978 18582 12789 SYNTHESIS OF EPOXY (EET) AND DIHYDROXYEICOSATRIENOIC ACIDS (DHET)%REACTOME%R-HSA-2142670.1 Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) 13850 13110 13078 13077 107141 13076 72303 GSD II%REACTOME DATABASE ID RELEASE 57%5357609 GSD II 27357 DARPP-32 EVENTS%REACTOME%R-HSA-180024.1 DARPP-32 events 110385 19088 18749 18577 238871 19045 21770 640703 18578 19052 19087 19053 19058 19085 73699 19056 19055 19084 12568 51792 19049 19057 18747 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX%REACTOME%R-HSA-68689.1 CDC6 association with the ORC:origin complex 23834 56452 242705 66634 13557 18392 26428 50793 18393 26429 13555 METHYLATION OF MESEH FOR EXCRETION%REACTOME DATABASE ID RELEASE 57%2408552 Methylation of MeSeH for excretion 21743 PHASE 0 - RAPID DEPOLARISATION%REACTOME DATABASE ID RELEASE 57%5576892 Phase 0 - rapid depolarisation 12323 12289 108058 12295 12322 12297 12293 81905 12298 12299 14167 14168 54377 20264 14166 399548 20271 20272 20273 20274 110876 14169 54378 81904 12296 72821 54652 12288 640703 20266 235281 12325 24046 20265 20269 110880 12292 140723 319734 12294 56808 54376 12300 RHO GTPASES ACTIVATE PKNS%REACTOME%R-HSA-5625740.1 RHO GTPases activate PKNs 319181 100039786 232440 382522 319176 55948 22631 22629 22628 76804 71960 320795 19046 99982 17978 624153 67938 11835 625328 51788 15077 319149 67268 263803 15267 319183 19353 17931 11848 319182 319178 319186 319190 17886 109333 319168 22627 11852 68458 319167 54401 11853 18607 17880 12532 329251 319188 15270 77579 319169 78303 17904 CLEARANCE OF DOPAMINE%REACTOME DATABASE ID RELEASE 57%379401 Clearance of dopamine 17161 12846 13162 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION%REACTOME DATABASE ID RELEASE 57%211733 Regulation of activated PAK-2p34 by proteasome mediated degradation 59029 19184 19179 22190 20422 19186 19188 667035 19182 19181 57296 23997 67151 66997 66413 19185 66998 53380 16913 228769 19192 70247 19175 19177 67089 26445 17463 19166 19170 69077 21762 23996 103554 16912 26444 26446 19173 26443 19172 73902 19167 26441 19171 26442 26440 22123 224105 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1%REACTOME DATABASE ID RELEASE 57%1839122 Signaling by activated point mutants of FGFR1 64654 14173 14164 80857 14180 14182 14175 14177 TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 57%379724 tRNA Aminoacylation 22321 71941 234734 15115 70120 226539 69955 70791 244141 102436 230577 224805 23874 66590 20226 68915 70223 110960 353172 71807 67895 74776 27267 22375 104458 226414 85305 71984 107045 66143 212679 97541 67417 70560 13722 381314 231872 107271 107508 216443 109093 105148 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%R-HSA-3359463.1 Defective CUBN causes hereditary megaloblastic anemia 1 14603 93835 65969 FGFR3B LIGAND BINDING AND ACTIVATION%REACTOME%R-HSA-190371.1 FGFR3b ligand binding and activation 14164 14172 80857 14180 PI5P, PP2A AND IER3 REGULATE PI3K AKT SIGNALING%REACTOME%R-HSA-6811558.1 PI5P, PP2A and IER3 Regulate PI3K AKT Signaling 16334 12223 211323 100042150 19247 16337 13645 327826 12519 12524 18710 18183 14172 26417 74769 26413 18707 18709 16367 13866 14360 14186 77647 16590 117150 19052 64654 19053 80903 14173 14170 73699 14164 18717 12478 11651 15937 14178 80857 14180 51792 12487 14175 14177 13874 14165 18596 83961 21770 18708 26932 15200 18706 226849 18720 16818 26931 18719 225849 384783 108083 83379 67112 14388 22324 14174 13649 18595 18718 18591 DAP12 SIGNALING%REACTOME%R-HSA-2424491.1 DAP12 signaling 16822 12010 16643 57257 17444 22325 56438 19353 26395 67603 319520 12229 235584 26403 16416 12223 22177 54519 100042150 21894 11600 19060 19186 19188 327826 17169 194231 109905 27007 14161 226525 57296 67151 215449 18710 19185 66998 53380 14172 17967 15461 17463 83409 69077 29875 12912 26417 26413 12323 108058 12322 18015 59029 19197 19417 19184 19179 22190 20422 171463 14573 667035 19182 16590 240057 19181 64654 231474 14173 80903 14164 23997 66997 18039 218397 667803 110135 14585 14178 80857 228769 14180 70247 67089 14586 14587 14175 21762 14177 23996 20416 11876 14165 26554 18596 109880 16399 54153 18708 15200 640703 18706 18673 83433 12325 16818 16706 69601 83379 22371 73902 233046 114716 12981 19415 63953 14174 12982 19252 16653 12984 240672 13537 12988 67836 16186 13385 14588 211323 16184 11836 20963 18188 20740 20739 13645 16185 16452 216869 109689 18176 72399 70686 114715 240168 14268 66413 211255 18183 14083 16451 19192 16453 26445 19166 18218 12576 14812 76089 26444 26446 14811 26443 14813 19414 80297 14814 12575 74769 16183 20742 18707 18709 20741 21687 20743 16367 13866 14810 16192 26396 14360 16191 216148 114713 14186 19418 22123 20662 19052 14170 19053 19262 73699 640524 16913 75590 19175 19177 51792 19713 19170 22330 99571 13874 103554 16912 54401 83961 56637 16188 19173 19172 21770 107971 26932 100986 226849 18611 23980 20418 26931 320484 225849 384783 12675 245684 67112 110157 19167 26441 19419 11472 19171 545987 13649 70727 18595 26442 26440 101809 18591 18750 19088 16334 76850 18753 18754 236511 19247 16337 75778 15370 18752 104110 229709 12519 12524 606496 244650 18573 12015 56717 22084 224129 77647 11513 11512 239528 11515 11514 12371 98432 117150 18803 56458 234779 56484 213988 12326 11652 18717 12478 11651 15937 16440 78757 228775 12487 110355 18747 18574 16438 18749 217351 210044 18575 432530 233833 23797 104111 67605 18720 17246 56716 18719 214150 108083 19087 19085 18607 19084 14388 22324 19211 227743 18718 109270 17454 16439 58988 FORMATION OF ANNULAR GAP JUNCTIONS%REACTOME DATABASE ID RELEASE 57%196025 Formation of annular gap junctions 67300 74325 14609 13429 12757 13132 11773 13430 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 57%1445148 Translocation of GLUT4 to the plasma membrane 17884 17883 20912 240028 17885 100039786 104215 17879 68938 108099 16569 19079 108097 57915 19082 56044 55948 20619 211446 20336 74741 17913 53413 22631 20909 22629 22628 102058 19325 667772 544791 17274 53869 22318 228850 19353 16579 20528 107371 68328 105504 17882 11652 11651 22627 17918 16568 108079 241113 54401 640703 19341 69940 210789 68365 66482 140781 17888 ARACHIDONATE PRODUCTION FROM DAG%REACTOME%R-HSA-426048.2 Arachidonate production from DAG 23945 76192 231871 269060 66082 DNA REPLICATION INITIATION%REACTOME DATABASE ID RELEASE 57%68952 DNA replication initiation 59001 18973 66979 18974 18969 19075 18968 19076 SIGNALING PATHWAYS%REACTOME%R-HSA-162582.4 Signaling Pathways 13363 66753 20423 16147 67629 69928 236930 68014 208628 52696 67733 83815 102920 76464 66570 83431 13000 100039026 108911 76499 18221 12617 26886 66934 59013 98758 15382 24117 20319 22416 216795 12805 74499 22417 20377 16974 20182 433759 80707 67821 20183 320394 226747 66442 12615 72155 108000 13001 60411 625534 232987 66468 67052 52504 67139 70385 71876 70454 244495 381318 66336 67037 216965 72415 56430 66977 12235 26951 56044 12000 14725 16568 16572 16971 73804 74764 229841 16593 75717 108664 76936 19205 65112 20901 56424 170749 17872 14225 68010 243764 19246 20811 242864 140795 67168 78826 14678 14677 14679 70839 74191 57385 233571 235036 18441 18442 78134 574402 18127 107221 242851 21416 11798 16846 233081 225642 16563 16573 104215 11607 232943 18783 11998 106628 320129 26934 13043 21336 19346 73470 16443 74325 228421 16594 19109 15563 15562 15560 15550 15566 15565 15552 15551 15559 15558 15557 15874 269275 11481 14783 12622 11479 11480 20750 12929 14786 71785 21827 214498 235497 107746 18815 21828 17974 18791 15245 66573 57810 20287 11517 59287 14706 14607 14696 192662 14526 18759 14527 224014 11516 269608 14602 20598 14688 101497 14708 13605 14693 94275 14709 75547 26382 14601 16800 14697 16801 57294 667739 76804 320795 99982 14632 74239 240888 117606 19206 104346 14634 56438 319757 18222 230500 68525 71742 76857 14451 20747 59056 16476 17260 13712 13057 26395 192656 17874 67603 13058 100040260 223864 319520 17970 12229 17972 26419 17969 11820 22411 102626 18099 20203 17258 12703 56508 240756 14699 94253 66066 59036 14700 80288 14701 21414 14695 16842 93896 21415 14652 19091 14704 77578 14702 68911 381853 21887 14710 72135 64337 73086 18187 26362 235584 27371 16179 26403 16416 12223 54519 14357 227325 13386 100042150 74198 21894 11600 19060 19186 19188 327826 17169 194231 109905 14161 226525 57296 67151 215449 18710 19185 66998 53380 14172 21338 17967 15461 17463 83409 69077 29875 110651 20210 21333 12234 21334 17164 21337 72349 329252 20111 239405 12912 228770 107515 26417 14160 72780 26413 23939 20112 68092 433702 235339 208643 407821 192199 18604 27273 18597 228026 68263 236900 12323 108058 27402 12322 18015 59029 19197 19417 19184 19179 20422 171463 14573 19182 16590 240057 19181 231474 80903 23997 66997 18039 218397 110135 14585 14178 228769 70247 67089 14586 14587 21762 23996 20416 192176 11876 12385 14165 76117 26554 208846 18596 232201 109880 57778 16399 20166 54153 404710 15200 13542 640703 13544 18673 78514 12325 16330 16818 233071 16706 270163 69601 100038946 83379 16886 22371 73902 233046 114716 12981 19415 63953 14174 12982 19252 16653 12984 240672 107589 13537 17904 12988 67836 16186 13385 14588 211323 16184 11836 18667 20963 18188 20740 20739 13645 16185 16452 228839 216869 109689 18176 72399 18049 70686 545156 114715 18211 240168 18212 14268 66413 211255 18183 14083 16451 19192 16453 26445 19166 18218 15170 16194 14812 16193 76089 58804 26444 260409 26446 235072 14811 19374 26443 19373 14813 17979 19414 54721 80297 18612 14814 104252 74769 225724 16183 50772 20742 218294 18707 229776 18709 226861 20741 21687 14128 20743 17242 16367 13866 14810 16192 26396 14360 16191 216148 114713 14186 74915 19418 22123 18167 76854 58175 18168 12854 56838 227288 240816 12765 21871 14739 236915 217212 381810 227326 330122 14823 624910 20662 14170 19262 640524 100039636 22065 74126 16913 75590 19175 19177 19713 19170 22330 99571 67839 13874 11966 19065 103554 16912 19064 18619 54401 83961 100038965 20606 16188 100039973 19173 110312 19172 107971 51791 22068 387513 100986 18611 65086 11973 17329 23980 387349 20418 57254 320484 11964 387342 384783 110935 626596 245684 12145 67112 110157 108073 11938 19167 108069 26441 84112 53313 19419 19736 11472 14825 11937 387616 19171 545987 50778 12775 13649 70727 12776 20310 18595 26442 12778 12768 26440 19229 67792 12771 101809 18591 12773 18750 14296 19088 20674 16334 20675 76850 22415 18753 67087 18754 20671 236511 20668 19247 22423 66290 16337 213788 75778 68339 26946 15370 20682 18752 212398 104110 20187 229709 20677 12519 319478 12524 67772 104443 230777 229214 237362 15171 11974 20679 20890 242341 73739 20680 54615 14815 227717 387285 114143 11975 11972 77411 68775 21841 66237 93686 66556 14106 54411 20293 14254 13489 11548 606496 11549 66144 12671 11550 12669 12672 18241 21843 338375 14181 72514 66335 13490 76252 13491 107568 244650 18573 12015 56717 22084 224129 77647 11513 11512 239528 27060 11515 11514 73834 12371 140494 98432 117150 18803 56458 56484 213988 12326 11652 18717 12478 11651 15937 243270 16440 80885 78757 228775 12487 71704 110355 15183 18747 213498 18574 102098 16438 277360 18749 226970 217351 207212 210044 20663 18575 73341 432530 208117 233833 56349 23797 17136 104111 18053 67605 12125 18720 68585 17246 171207 56716 24001 18719 235402 214150 223435 108083 109904 19087 19165 19085 12070 18607 100039623 19084 72843 14388 100042305 22324 56321 396184 109934 71436 69632 19211 18377 399558 30938 227743 21844 18718 17207 109270 230972 17454 213649 16439 53972 58988 14163 58182 246313 23832 319197 233079 14763 229791 18217 22045 272031 217369 20312 246691 75769 20299 22044 14744 233080 20302 13051 433586 436440 252837 280287 208188 56696 15507 14063 12424 12209 12425 13618 24111 18101 68039 171469 14715 114229 23925 67405 235044 16963 226278 13615 13614 58861 57260 14714 54199 20303 238377 17165 20295 20306 20296 20292 50501 13616 13617 623503 22439 20290 14829 59289 75273 21372 94093 210198 13733 22414 93735 19207 26364 22421 22422 110326 83770 22412 14371 19664 22409 93897 22413 22420 83771 64214 381073 71729 353165 17773 244701 23919 15199 56066 239336 109648 12374 20315 11609 387512 15945 18386 94226 20609 14427 57253 18389 14429 12568 14428 14293 387347 19015 20608 55985 574417 208990 14289 14294 110168 20297 18166 14419 387355 18155 20304 30878 387356 20604 216749 56470 14745 242093 13610 12801 264064 13609 140486 67865 353148 19737 12802 387353 66102 12769 387515 13611 387348 19734 108068 53978 246709 268934 20185 20602 22190 26409 667035 93836 64654 14173 14164 68652 66724 22034 66513 20848 18216 80857 12426 224065 14180 13349 16995 20846 216152 70086 14175 14177 239283 67384 226304 20851 12766 12062 20850 18387 14389 80901 14767 18708 12777 56183 18706 12061 20605 433292 110279 20311 20300 23796 14580 13382 14159 97064 12991 18787 12579 12576 211586 19650 26965 15182 13557 12575 13555 21781 13819 12914 218772 328572 15251 19401 22339 56505 19411 19052 19053 73699 21752 21402 12567 13559 20683 12443 104394 51792 12445 108079 241113 26416 11789 56637 93687 72345 21770 26932 226849 12387 12005 26931 22601 225849 12675 19697 18033 18035 16151 16150 234130 18131 84035 13380 73016 18129 16973 18128 56811 18132 67710 69912 17749 66420 17283 245841 21815 333639 103468 20021 69241 108099 29857 19079 108097 19094 19082 260305 103806 234865 69736 11545 20482 20481 59015 69833 68705 20022 69920 445007 231329 98053 19386 100043714 20020 81004 52666 232157 18412 19730 68151 71520 13448 14158 18654 19769 19273 14459 19762 56433 16798 51813 170771 14257 56332 73130 270118 50523 19735 50780 68473 64143 211652 30930 14797 64010 65114 75723 71514 56533 12904 16477 13992 22419 56274 20218 19049 58231 12827 12829 12839 18817 12830 12835 12833 11603 12828 12826 237222 14600 19116 18472 27373 230126 13589 76707 19046 75786 17931 70737 13684 75705 258659 258640 258292 83554 259147 14313 258163 258443 258656 257898 258381 257917 258371 404346 258222 258296 258616 258704 258151 258405 258563 18313 258470 258672 258153 258690 18314 18312 258821 258373 18186 257884 258358 258937 258702 258763 258179 258703 258271 259049 259066 258025 258857 258439 258836 668035 258075 259089 259012 18369 259095 258657 259092 258542 258769 16952 258729 258347 258935 258321 259071 258487 258486 258939 258609 258268 258908 258749 259097 258318 258985 56858 258420 258776 57251 258515 259035 258531 258352 257972 258507 259063 258814 258946 258305 258759 258407 258804 258287 259074 258975 258275 404331 258506 258775 258338 258544 258387 258772 258354 259051 57271 259002 100043474 258424 259100 17392 258147 258469 258455 258206 100038859 19882 259058 15451 258746 20733 258481 15235 259045 258355 257883 17395 258325 20732 258536 56015 259019 258562 258881 258713 258098 258302 258756 14682 258478 14675 259036 21390 259034 14676 258614 14672 258319 14674 258914 258710 258238 258694 258700 404315 259119 259075 258819 257905 258720 259047 258717 18366 404318 18367 436002 258154 20607 258600 258160 207911 258036 18341 258427 18330 258350 258178 404222 109791 58194 68453 18550 23945 18453 11772 106766 18553 11771 71770 11806 11808 238055 11807 18552 69060 19045 12757 17228 232910 11773 232345 16592 16956 11814 19047 16835 11816 16480 232906 12927 20459 11848 19303 12388 21933 14102 14103 22035 16323 22094 12389 26361 67300 54140 20586 93742 14308 16324 12562 16456 207728 23984 23938 81489 74370 19659 81897 63857 65107 79235 67861 55938 26415 19662 19660 239393 75669 170752 225326 24069 14633 16396 12366 241489 19092 54611 18576 12840 12834 245026 11540 11539 12841 11541 11542 14370 14734 93840 66313 13543 14365 14367 75788 22418 57265 17346 116701 12402 24064 14816 54485 13388 108071 16450 16449 17973 17096 57257 14735 20430 56378 330319 83767 242687 22325 11350 15519 330662 66713 12640 14362 56513 16866 106042 14366 14369 105782 22030 74256 53376 229603 259302 19353 30941 14270 14082 21937 21926 22258 12370 71609 19766 21929 12447 71951 22627 23888 106025 22342 117600 223666 14733 73916 213081 271639 81896 21821 106633 73668 67661 103978 319181 77583 12237 214240 22158 100039786 245866 56150 70300 380614 380718 216080 67588 382522 55948 22059 22631 22629 22628 12534 12566 244585 74682 665270 12166 12168 104709 17130 55994 319183 17129 218441 14314 23893 12236 319182 319178 319186 12156 319190 30955 320207 320634 15466 99296 15465 17120 225192 319152 81601 107995 12532 319188 15270 14681 12649 14685 78303 14686 14687 12167 18121 258322 18328 12895 258866 258270 258990 18322 259053 12894 258586 258869 259041 241452 258248 258357 259110 546726 259109 28200 258580 108841 258582 13082 258587 19378 259112 11668 258362 26876 258363 232174 258575 19682 258853 242285 258601 56847 258650 11522 80706 237320 259106 20148 258675 12903 259014 98711 259054 12702 404317 216454 258636 105014 259115 17252 18365 258805 258961 258736 258882 258097 259015 258991 258944 258992 258941 258299 258618 242425 258216 228228 244187 258572 259004 667918 257916 258697 258752 54393 258925 258896 259122 258924 170639 668825 259113 259017 258155 258680 258303 258620 29849 258933 258606 18317 257962 258310 83702 258395 258334 258196 18357 258715 18315 18346 258267 258922 258207 258316 546747 18343 258408 257909 258432 258832 258608 259067 18310 259040 329460 258794 258281 404329 258677 258846 117004 258016 258027 404319 545140 258930 258658 258831 218066 259013 258105 259111 258453 258706 258573 18331 257985 258340 258854 258673 258039 258980 258458 14680 18324 18796 18795 11797 18762 18751 20698 11796 16542 18798 20338 18797 233406 16709 330914 11854 20807 69288 116891 228543 73910 216440 56419 71960 214952 80837 17978 223701 67938 214137 94190 73167 77337 544963 381293 105349 75404 50768 67268 20181 228482 216831 70719 263803 71085 239027 105855 170758 94221 245880 70497 140580 69581 50884 23912 108100 13367 56443 18643 68524 18645 11461 78816 16885 268970 329165 14787 101314 237038 140579 236920 52428 19878 11855 69710 545481 19765 17886 228359 56212 226652 76884 11856 12928 109333 22612 19354 18479 12549 11852 80987 68458 71409 76709 71709 17925 243362 71893 215280 214804 225358 11465 22379 73178 11853 22376 12704 68089 244867 74117 224480 11308 58996 14026 74734 67771 211896 11867 14570 231532 75415 11857 218581 100039683 14569 320271 17880 329251 246710 14567 18016 212285 77579 76378 241275 216445 106952 71302 319430 19739 12772 24012 12458 18018 18019 17444 13430 18021 22192 103967 18481 224105 19216 19218 14764 19220 381022 19042 64930 12283 72149 213464 13631 66096 23808 18755 331374 56077 14065 66082 320127 380921 110524 104418 13685 13139 54170 14062 245670 14673 110197 68576 76192 20869 231871 68441 66508 269060 227154 11552 52187 14064 69008 217480 105787 12273 15139 12266 12267 66105 207521 19395 22341 74493 22340 57349 56744 100683 385643 84092 14205 21888 21885 21886 19056 19055 13429 52440 20852 19204 18761 50779 19058 50782 21682 83814 76686 432940 18107 59079 20779 76890 17179 19219 19248 12633 24105 268749 22029 66552 73218 12767 107951 12454 12774 18108 103573 235611 26564 26563 72949 12455 11487 13859 11489 19272 11491 54126 13858 13854 16206 24063 20404 17200 94212 232440 53627 13016 12539 16000 13017 16370 14539 16002 12057 16001 13603 353344 30044 20132 57811 51801 223780 11535 12311 12310 56089 54409 22408 17999 54152 624153 625328 51788 15077 54607 319149 14773 16867 381413 19877 319239 12367 19214 80910 21873 14309 14272 238725 20971 212108 100043254 20969 22353 17202 17199 17201 17203 26385 22095 209512 71223 215855 114640 218461 22354 16336 22410 21872 93690 382348 12550 15530 110385 18577 13492 19228 22139 213527 238871 19773 12922 14608 18583 18584 18578 13488 239530 215854 20970 29863 12918 14761 227289 19226 111174 15529 12921 22355 19217 19227 383563 381489 503558 16412 19222 11554 16410 11556 140498 18519 14368 207742 16923 11555 11835 56207 66725 93695 107477 243923 102294 11304 77974 19771 70061 19892 20897 17921 77480 19661 235033 27400 54598 23921 17127 18429 18430 245650 19674 18201 14694 14919 56307 237178 24013 110606 75624 14913 73582 269523 11813 79221 170787 225164 208727 15208 240055 15205 15213 76580 15185 232232 59040 70315 56198 15214 15184 16319 19057 14939 14425 21951 54613 18002 56324 14479 14061 11799 103236 58994 20844 54198 110350 19719 140484 16848 17131 17305 14595 18011 21826 18610 21825 224143 18390 21803 21813 21812 17869 17125 17128 17126 15239 319169 19156 56233 68031 11606 12638 319176 52276 11551 11553 18587 20877 225600 214111 18588 20215 12788 212541 110379 15267 15485 14534 13982 319168 18976 319167 22284 12006 100042343 20443 PKA ACTIVATION IN GLUCAGON SIGNALLING%REACTOME DATABASE ID RELEASE 57%164378 PKA activation in glucagon signalling 19088 18749 210044 432530 224129 11513 11512 104111 11515 11514 104110 19087 19085 19084 18747 PHASE 2 - PLATEAU PHASE%REACTOME DATABASE ID RELEASE 57%5576893 Phase 2 - plateau phase 12289 12295 12297 12293 57442 81905 12298 12299 54377 54378 57814 81904 12296 66240 54652 12288 100986 16509 12292 246133 140723 319734 12294 16535 56808 54376 12300 DEFECTIVE B4GALT7 CAUSES EDS, PROGEROID TYPE%REACTOME%R-HSA-3560783.1 Defective B4GALT7 causes EDS, progeroid type 15530 14734 14735 13003 12032 20971 103978 20969 11603 20970 121021 15529 13004 12111 29873 14733 71951 13179 23888 BLOCH PATHWAY%REACTOME DATABASE ID RELEASE 57%6807047 Bloch pathway 13360 74754 235293 13595 SYNTHESIS OF CL%REACTOME DATABASE ID RELEASE 57%1483076 Synthesis of CL 66586 SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 57%373755 Semaphorin interactions 18186 22177 21894 20356 12568 12631 71960 15519 109700 67938 18481 13866 14360 67268 19264 224105 12569 19877 232906 18846 12933 19353 22240 227377 26757 20346 11848 65254 16885 19878 15516 17886 56212 18717 20130 19354 18479 11852 213498 214968 67784 140571 243743 11853 56637 18845 83433 16886 17880 235611 69632 17295 12934 20354 20358 223881 12517 77579 14159 20349 18844 16412 54712 17904 20361 20351 METABOLISM OF INGESTED MESEO2H INTO MESEH%REACTOME%R-HSA-5263617.2 Metabolism of ingested MeSeO2H into MeSeH 50493 PYRIMIDINE SALVAGE REACTIONS%REACTOME DATABASE ID RELEASE 57%73614 Pyrimidine salvage reactions 57813 80914 21877 22271 13178 72962 22245 67365 76654 72269 DEFECTIVE CHST14 CAUSES EDS, MUSCULOCONTRACTURAL TYPE%REACTOME DATABASE ID RELEASE 57%3595174 Defective CHST14 causes EDS, musculocontractural type 121021 13003 12032 13004 12111 29873 13179 MITOTIC PROPHASE%REACTOME%R-HSA-68875.1 Mitotic Prophase 18750 218210 66679 18226 69912 227720 319181 54563 22367 18817 223921 103468 70699 14245 232440 72787 70099 18751 19324 269113 231042 234865 69736 19069 382522 107939 319176 52683 170762 66352 382030 19645 26413 56041 59015 227699 624153 12534 67181 625328 18141 51788 15077 445007 12442 52432 108989 319149 70231 19386 76044 74498 69482 224640 71805 13726 78658 99412 76308 15267 319183 14211 319182 319178 67956 319186 319190 56205 59021 19052 19053 64898 73699 217718 671392 67121 59125 319168 16906 51792 59126 59046 319167 319152 64899 244329 319188 15270 380664 319169 78303 23825 HH MUTANTS THAT DON'T UNDERGO AUTOCATALYTIC PROCESSING ARE DEGRADED BY ERAD%REACTOME%R-HSA-5362768.1 Hh mutants that don't undergo autocatalytic processing are degraded by ERAD 66753 20423 19186 19188 269523 57296 67151 66413 19185 66998 53380 19192 20338 17463 26445 19166 69077 26444 116891 26446 216440 26443 22123 59029 19184 19179 22190 20422 667035 19182 19181 23997 66997 74126 16913 228769 70247 19175 67089 19177 19170 21762 23996 103554 16912 19173 19172 73902 19167 26441 19171 26442 26440 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION%REACTOME%R-HSA-2730905.1 Role of LAT2 NTAL LAB on calcium mobilization 211323 20963 13645 18183 12576 17096 74769 12575 18707 18709 16367 13866 56743 14360 14186 20662 19052 14170 19053 73699 51792 13874 56637 83961 21770 26932 226849 26931 225849 384783 12675 67112 13649 18595 18591 12223 16334 76850 100042150 236511 19247 16337 75778 15370 327826 12519 12524 18710 14172 12912 26417 26413 606496 244650 12015 56717 22084 77647 239528 12371 98432 16590 117150 64654 56458 14173 56484 80903 14164 213988 11652 18717 12478 11651 15937 14178 80857 14180 78757 228775 12487 14175 14177 217351 14165 18596 14389 233833 23797 18708 15200 67605 18706 18720 17246 56716 16818 18719 214150 108083 83379 18607 14388 22324 14174 19211 227743 18718 109270 17454 58988 CARDIAC CONDUCTION%REACTOME%R-HSA-5576891.1 Cardiac conduction 18519 12289 12295 12297 12298 15257 52150 16530 16525 72258 16528 16526 12294 56808 54376 12300 223604 12293 11931 16515 57442 110893 81905 16520 12299 13400 16527 65973 54377 230103 22063 16518 18160 241769 18091 18159 18125 80334 21388 56461 11928 54378 57814 20541 53419 232975 81904 98660 70357 20191 20192 100986 11932 11938 53313 11937 381290 320707 67972 14226 20190 11933 217826 229709 57780 14167 14168 59095 14166 20866 20928 16529 109552 332396 109305 14169 230899 11941 14463 66240 72821 54652 21954 16514 269717 210741 20266 211480 235281 24046 16508 20265 20269 16509 110880 110891 16511 56543 76757 246133 140723 16506 319734 16535 15258 108017 74571 12323 108058 12322 56188 20264 399548 20271 20272 20273 20274 110876 16440 18747 16438 12296 12288 640703 12325 12292 97064 16439 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY%REACTOME DATABASE ID RELEASE 57%3301854 Nuclear Pore Complex (NPC) Disassembly 218210 66679 18226 69912 227720 54563 223921 103468 70699 72787 217718 59125 269113 231042 234865 59126 69736 19069 107939 170762 59015 227699 12534 18141 445007 12442 108989 19386 69482 71805 NEGATIVE FEEDBACK REGULATION OF MAPK PATHWAY%REACTOME DATABASE ID RELEASE 57%5674499 Negative feedback regulation of MAPK pathway 110157 109880 26396 26395 26417 26413 DEFECTIVE POMT2 CAUSES MDDGA2, MDDGB2 AND MDDGC2%REACTOME%R-HSA-5083629.1 Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2 13138 MITOCHONDRIAL FATTY ACID BETA-OXIDATION%REACTOME DATABASE ID RELEASE 57%77289 Mitochondrial Fatty Acid Beta-Oxidation 17850 110821 66904 15107 109136 93747 11364 67460 11363 71985 231086 11370 13177 102632 97212 11409 73724 ACTIVATION OF PKB%REACTOME%R-HSA-165158.1 Activation of PKB 18607 11652 75778 228775 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION%REACTOME%R-HSA-2032785.2 YAP1- and WWTR1 (TAZ)-stimulated gene expression 18519 12914 56406 109151 81004 15257 21678 21679 21677 18091 21676 21388 19013 229003 21372 19014 230899 12393 14219 14463 66993 22601 59035 17978 20181 97064 15258 17977 SIGNALING BY WNT%REACTOME DATABASE ID RELEASE 57%195721 Signaling by Wnt 14370 93840 66313 13543 14368 14365 207742 14367 75788 22418 57265 14706 14696 14688 14708 14693 14709 14697 18018 18019 27373 18021 13000 100039026 56438 21416 14362 56513 11798 106042 14366 14369 105782 19353 381022 22411 18099 14699 240756 66066 94253 14700 59036 22414 14701 80288 93735 213464 22421 22422 14695 21414 23808 16842 21415 22412 14704 19091 14702 77578 68911 14710 21887 64337 72135 22409 22413 22420 319181 19186 19188 24117 20319 57296 22416 67151 216795 19185 66998 53380 17463 74499 22417 382522 69077 20377 16974 12234 433759 329252 22631 239405 228770 74493 107515 14160 72780 407821 192199 100683 84092 12322 59029 319183 19184 13001 21888 19179 22190 20422 319182 21885 26409 319178 21886 667035 319186 319190 19182 19181 19056 23997 19055 66997 228769 70247 67089 21762 23996 208846 26554 21951 74325 13542 13544 640703 319152 81601 19058 73902 319188 15270 14681 78303 14686 11772 216869 11771 71770 66413 19192 26445 19166 103236 26444 26446 26965 26443 12757 232910 11773 54198 22123 12914 328572 11848 56505 19052 12389 19053 73699 67300 21752 21402 16913 19175 19177 51792 17869 20586 19170 103554 16912 11789 56637 93687 19173 72345 19172 21770 26932 226849 12387 12005 26931 103573 225849 19167 26441 19171 234130 84035 13380 73016 26564 16973 26563 26442 56811 26440 319169 18750 14296 18796 20674 20675 18795 76850 22415 67087 20671 236511 20668 22423 17283 68339 20682 18752 212398 20187 20677 232440 319478 53627 67772 13016 18751 13017 20679 20890 68031 73739 20680 18797 319176 22408 18587 225600 624153 18588 625328 51788 15077 319149 170758 15267 18643 239528 213988 68151 11652 11651 19092 319168 19354 16440 214498 22410 56433 235497 319167 16438 73130 217351 233833 30930 14797 12006 65114 18719 214150 22419 17454 16439 DNA REPAIR%REACTOME DATABASE ID RELEASE 57%73894 DNA Repair 72584 18973 19687 69263 67967 19718 22210 99375 18972 108679 13194 18538 19891 69745 68240 69928 18971 58206 58186 26370 231642 27015 68026 80905 216835 22632 11350 59001 72151 106344 76843 230484 66979 18974 56438 68275 14375 26447 22594 382913 17193 71726 18207 18294 56210 66983 71101 71890 71991 19714 16882 26419 233875 217069 93765 22591 67439 57905 18861 225280 17688 17350 17685 20892 22385 11834 56469 108138 26909 72774 28000 17535 12021 319181 19060 70620 269523 15204 70681 240087 12189 74153 11920 26891 231724 382522 20610 237911 70238 100043806 210766 319955 327762 27223 21975 22059 19355 19358 19359 20184 12848 19367 107986 12566 269582 56456 59004 22427 22224 19356 12144 70020 235559 56791 319183 100038882 14048 22190 14049 193796 319182 319178 230674 667035 319186 14051 93836 14050 319190 11785 12427 107823 229615 26894 19364 19360 19365 235610 107976 319152 68251 81601 225182 19361 27354 17686 15574 19822 50883 77593 26572 252870 22596 319188 232314 19090 15270 12649 56420 78303 66131 21853 12428 50721 208836 66467 93762 14884 68142 330554 77782 12572 272158 22230 75570 17420 59047 71885 67196 104806 268420 56196 69090 51869 77987 104884 54125 140917 72775 14087 17314 26895 67030 328572 319583 56505 227195 70603 100043429 26754 26893 66671 268395 23894 13871 13872 209357 14885 13716 21399 100039592 235134 67710 17749 66420 245841 20021 56249 69241 74335 109275 68098 244666 217365 56031 26430 11792 18970 11545 16881 14156 11546 69833 20022 69920 14088 231329 211651 100043714 20020 67513 26383 69113 60534 11461 56626 69714 55947 75452 55982 101831 227525 237211 100040608 12190 52864 233826 22196 268465 22592 50505 13870 68058 114714 57434 224008 104416 209334 22590 19362 71711 19363 269400 HDR THROUGH MMEJ (ALT-NHEJ)%REACTOME DATABASE ID RELEASE 57%5685939 HDR through MMEJ (alt-NHEJ) 27354 22594 17535 11545 19360 14156 11546 77782 225182 16882 SUMOYLATION OF TRANSCRIPTION FACTORS%REACTOME%R-HSA-3232118.3 SUMOylation of transcription factors 116870 12578 22196 27223 22059 20687 17246 17342 21420 21419 56469 100043429 59004 20610 229615 ACYL CHAIN REMODELLING OF PC%REACTOME DATABASE ID RELEASE 57%1482788 Acyl chain remodelling of PC 26971 18784 14792 78390 18783 66857 270084 232889 53357 67452 18779 210992 225845 18782 66350 329502 18778 67216 271844 237625 99010 665270 26970 26565 MMR%REACTOME DATABASE ID RELEASE 57%5358508 MMR 18861 67967 16881 17688 17350 17685 18972 18538 19891 69745 68240 18971 17686 68275 26909 THE PROTON BUFFERING MODEL%REACTOME%R-HSA-167827.1 The proton buffering model 74011 22227 20523 22228 22229 PHASE 1 - INACTIVATION OF FAST NA+ CHANNELS%REACTOME%R-HSA-5576894.1 Phase 1 - inactivation of fast Na+ channels 12289 12295 12293 12297 81905 12298 12299 54377 80334 56461 54378 81904 70357 12296 54652 12288 16508 12292 56543 140723 16506 319734 12294 56808 54376 12300 GRB2 EVENTS IN EGFR SIGNALING%REACTOME%R-HSA-179812.1 GRB2 events in EGFR signaling 56438 26395 67603 319520 235584 26403 16416 12223 54519 100042150 21894 11600 19060 19186 19188 327826 17169 194231 109905 14161 226525 57296 67151 215449 19185 66998 53380 14172 17967 15461 17463 83409 69077 29875 26417 26413 12323 108058 12322 18015 59029 19197 19417 19184 19179 22190 20422 171463 14573 667035 19182 16590 240057 19181 231474 64654 80903 14173 23997 14164 66997 18039 218397 110135 14585 14178 80857 228769 14180 70247 67089 14586 14587 14175 21762 14177 23996 20416 11876 14165 26554 18596 109880 16399 54153 15200 640703 18673 12325 16706 69601 83379 22371 73902 233046 114716 12981 19415 63953 14174 12982 19252 16653 12984 240672 13537 12988 67836 16186 13385 14588 211323 16184 11836 18188 20740 20739 13645 16185 16452 216869 109689 18176 72399 70686 114715 240168 14268 66413 211255 18183 14083 16451 19192 16453 26445 19166 18218 14812 76089 26444 26446 14811 26443 14813 19414 80297 14814 16183 20742 20741 21687 20743 16367 13866 14810 16192 26396 14360 16191 216148 114713 14186 19418 22123 20662 19052 14170 19053 19262 73699 640524 16913 75590 19175 19177 51792 19713 19170 22330 99571 13874 103554 16912 54401 83961 16188 19173 19172 21770 26932 107971 226849 100986 18611 23980 26931 20418 225849 320484 384783 245684 67112 110157 19167 26441 19419 11472 19171 545987 13649 70727 18595 26442 26440 101809 18591 RHO GTPASES ACTIVATE WASPS AND WAVES%REACTOME DATABASE ID RELEASE 57%5663213 RHO GTPases Activate WASPs and WAVEs 105855 245880 50884 19353 108100 56443 68524 11461 329165 101314 12229 76884 14083 80987 76709 17973 215280 11465 73178 22376 20430 68089 56378 74117 330319 11308 83767 67771 242687 11867 26417 26413 11350 66713 ORGANIC ANION TRANSPORT%REACTOME DATABASE ID RELEASE 57%561048 Organic anion transport 19879 18399 20521 108114 COX REACTIONS%REACTOME%R-HSA-140180.1 COX reactions 19224 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA)%REACTOME%R-HSA-400206.1 Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) 12896 56406 12894 109151 14080 20933 80509 21677 67219 11806 15360 100040592 229003 11303 17764 11807 23989 69790 170826 17979 18181 76199 28077 76267 66999 19731 57875 394434 12914 328572 11364 11655 75613 12491 94112 14137 18631 20683 21372 14219 381379 66993 12753 73690 17436 59024 22601 216154 195733 20788 327987 20859 14200 108098 217166 18045 94185 18670 14081 26379 19017 26457 11520 19016 67279 19013 66113 19014 11606 100040843 68975 13122 70625 234959 19883 70208 264064 17978 20186 171285 56771 18046 20181 17977 18044 20185 20602 11865 66172 107765 81004 21678 21679 21676 18143 26896 228775 15183 13076 69792 51813 67224 20466 78334 24001 59035 14373 50493 67381 97064 192191 DISEASES OF GLYCOSYLATION%REACTOME DATABASE ID RELEASE 57%3781865 Diseases of glycosylation 14734 100039649 13138 103978 20357 11603 140474 20356 207596 17829 100689 233744 224697 14264 18295 27047 116847 16545 17022 271127 14735 108154 208936 73732 239337 210417 223838 121021 330119 13004 17063 240913 12111 216725 29873 18636 229595 66548 11504 30806 13179 330267 23794 269328 13003 108153 12032 77739 20971 240322 20969 21826 21825 224116 353328 71951 23888 15530 235130 237360 269959 243369 279028 77794 20970 56229 15529 18131 18129 18128 14733 226866 18132 EPIGENETIC REGULATION OF GENE EXPRESSION%REACTOME%R-HSA-212165.1 Epigenetic regulation of gene expression 18519 194388 13626 12417 107932 21652 66467 216848 93762 14884 23942 15182 12572 93759 17420 18432 245688 110052 74016 116870 19646 21374 328572 20016 20018 81898 66671 56637 23894 22385 13871 13872 116871 209357 14885 101867 319169 14056 100041953 17749 66420 245841 319181 50724 234366 232440 54427 20937 382522 319176 269003 319955 433759 20467 94246 13433 11569 624153 13436 69833 625328 51788 60406 15077 13435 18140 17191 319149 100043714 17765 229542 66136 52615 21341 21340 15267 214133 319183 20017 110147 70333 667501 22130 57230 11461 319182 319178 319186 319190 21429 75316 64424 14534 20019 21339 319168 319167 71954 20466 56200 17192 52463 16468 319188 15270 78303 116848 NEGATIVE REGULATION OF FGFR1 SIGNALING%REACTOME%R-HSA-5654726.2 Negative regulation of FGFR1 signaling 14165 109880 19247 22190 17346 26417 667035 12402 327826 26413 24064 19052 67112 64654 19053 14173 14164 14174 80857 14180 51792 14175 14177 SMAC-MEDIATED DISSOCIATION OF IAP:CASPASE COMPLEXES%REACTOME%R-HSA-111464.1 SMAC-mediated dissociation of IAP:caspase complexes 12369 12367 11798 12371 66593 PLATELET ADHESION TO EXPOSED COLLAGEN%REACTOME%R-HSA-75892.1 Platelet Adhesion to exposed collagen 17096 243816 14127 16398 54368 14723 14729 14724 22371 109700 213119 14360 16412 SERINE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 57%977347 Serine biosynthesis 107272 236539 100678 ENDOGENOUS STEROLS%REACTOME%R-HSA-211976.3 Endogenous sterols 13078 68165 14148 19223 102294 13122 110115 13123 13074 17978 104086 13116 20186 13072 14149 13070 20181 13079 13075 13124 13121 56050 18976 17977 SIGNALING BY INSULIN RECEPTOR%REACTOME%R-HSA-74752.1 Signaling by Insulin receptor 667739 56438 26395 67603 319520 13684 75705 19042 64930 12283 72149 13631 66096 13685 54170 245670 68576 20869 68441 66508 227154 52187 69008 235584 105787 26403 16416 12223 54519 100042150 21894 11600 19060 19186 19188 327826 17169 194231 109905 14161 226525 57296 67151 215449 19185 66998 53380 14172 17967 15461 17463 83409 69077 29875 26417 26413 208643 12323 108058 12322 18015 59029 19197 19417 19184 19179 22190 20422 171463 14573 667035 19182 16590 240057 19181 231474 64654 80903 14173 23997 14164 66997 18039 218397 110135 14585 14178 80857 228769 14180 70247 67089 14586 14587 14175 21762 14177 23996 20416 11876 14165 26554 18596 109880 16399 18708 54153 15200 640703 18706 18673 12325 16706 69601 83379 22371 73902 233046 114716 12981 19415 63953 14174 12982 19252 16653 12984 240672 13537 12988 67836 16186 13385 14588 211323 16184 11836 18188 20740 20739 13645 16185 16452 216869 109689 18176 72399 70686 114715 240168 14268 66413 211255 18183 14083 16451 19192 16453 26445 19166 18218 14812 76089 26444 26446 14811 26443 14813 19414 80297 14814 74769 16183 20742 18709 20741 21687 20743 16367 13866 14810 16192 26396 14360 16191 216148 114713 74915 14186 19418 22123 21871 20662 19052 14170 19053 19262 73699 640524 100039636 16913 75590 19175 19177 51792 19713 19170 22330 99571 13874 11966 108079 103554 241113 16912 54401 83961 16188 19173 19172 21770 107971 26932 100986 226849 18611 11973 23980 20418 26931 320484 11964 225849 384783 110935 245684 67112 110157 19167 26441 19419 11472 19171 545987 13649 70727 18595 26442 26440 101809 18591 16334 66290 19247 108664 16337 75778 108099 19079 108097 11974 19082 242341 114143 11975 68775 11972 66237 54411 74370 66144 14783 338375 66335 76252 81897 56717 22084 27060 73834 140494 75669 225326 11652 11651 228775 18576 67605 56716 18607 14388 BETA DEFENSINS%REACTOME DATABASE ID RELEASE 57%1461957 Beta defensins 77674 12772 654464 654465 246082 244332 75400 24088 12458 629114 654460 246700 21897 266620 654459 ANCHORING FIBRIL FORMATION%REACTOME DATABASE ID RELEASE 57%2214320 Anchoring fibril formation 16774 16782 16780 21892 24087 12836 12153 GABA A (RHO) RECEPTOR ACTIVATION%REACTOME%R-HSA-977442.1 GABA A (rho) receptor activation 14408 328699 14409 ANCHORING OF THE BASAL BODY TO THE PLASMA MEMBRANE%REACTOME%R-HSA-5620912.1 Anchoring of the basal body to the plasma membrane 74201 67161 19088 320299 76816 18817 232944 217335 380718 654470 56455 140810 76478 71909 219072 214552 329795 237222 20873 260305 18536 77048 104318 22145 73738 26370 74470 219103 17997 99100 74360 382090 68121 18472 27078 27373 277939 12009 13589 54130 76707 230376 22628 66296 236266 78887 53885 18005 15519 381644 22154 12534 225745 214444 28135 231123 13427 13424 83922 208518 244585 75786 18541 103733 72140 101565 67590 78177 17274 53869 69654 22153 225659 227613 16328 53598 22142 68475 232987 22627 51792 18747 100986 75296 231214 52906 18000 216363 109242 67978 PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS%REACTOME%R-HSA-202427.4 Phosphorylation of CD3 and TCR zeta chains 12504 16818 94212 12500 12502 12501 14960 14968 19260 14969 19264 12988 19271 PYRIMIDINE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 57%500753 Pyrimidine biosynthesis 56749 69719 320685 22247 22171 ASTROCYTIC GLUTAMATE-GLUTAMINE UPTAKE AND METABOLISM%REACTOME%R-HSA-210455.1 Astrocytic Glutamate-Glutamine Uptake And Metabolism 20512 20511 14645 105727 MEIOSIS%REACTOME DATABASE ID RELEASE 57%1500620 Meiosis 17535 319181 19891 68240 232440 94244 12189 11920 74075 77053 382522 319176 50878 71846 64009 20962 319565 20957 21975 320558 66654 13006 15512 223697 56739 19357 140557 75459 497652 624153 21749 28113 625328 20842 12566 101185 51788 15077 57321 68275 319149 12144 15267 319183 21750 319182 319178 319186 319190 12567 319168 213389 16906 319167 24061 12190 22196 19360 17350 20843 114714 319152 225182 13404 27354 19361 55993 19183 217716 76915 17687 26972 319188 15270 319169 78303 104271 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR%REACTOME%R-HSA-451308.1 Activation of Ca-permeable Kainate Receptor 13385 110637 13383 640703 14807 14805 53310 14806 52589 14809 TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR%REACTOME%R-HSA-1679131.1 Trafficking and processing of endosomal TLR 81897 54445 142980 170743 72029 170744 13030 13040 13039 13038 22027 19141 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG%REACTOME%R-HSA-3359469.1 Defective MTR causes methylmalonic aciduria and homocystinuria type cblG 238505 210009 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA%REACTOME%R-HSA-112296.2 Post-Elongation Processing of Intron-Containing pre-mRNA 193116 107829 110809 225027 60365 331401 66511 68278 67337 228410 68219 19826 67996 73666 20382 53817 51786 71713 70579 66231 69823 233073 73826 69207 108014 386612 94230 17149 100040029 192160 625193 225160 68092 66441 54196 54188 433702 54451 108062 64340 192170 66899 622469 51796 21681 18789 20383 68134 269061 98985 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE%REACTOME DATABASE ID RELEASE 57%71406 Pyruvate metabolism and Citric Acid (TCA) cycle 382051 16828 27402 106557 16833 16832 319518 19015 80879 269951 57274 15929 20501 20917 55951 66945 12215 70456 14194 18293 381511 56451 217666 66052 109801 170718 235339 78920 11429 98314 18115 18604 12974 27273 13382 20181 18597 17448 228026 20916 68263 66925 236900 67834 76187 67680 PHOSPHATE BOND HYDROLYSIS BY NUDT PROTEINS%REACTOME%R-HSA-2393930.2 Phosphate bond hydrolysis by NUDT proteins 66358 214254 53893 75686 INHIBITION OF PKR%REACTOME DATABASE ID RELEASE 57%169131 Inhibition of PKR 19106 AXONAL GROWTH STIMULATION%REACTOME%R-HSA-209563.1 Axonal growth stimulation 18049 192662 11848 18053 P38MAPK EVENTS%REACTOME DATABASE ID RELEASE 57%171007 p38MAPK events 19730 29857 26416 19094 102626 64143 17164 26415 16653 15461 18176 56044 P75NTR NEGATIVELY REGULATES CELL CYCLE VIA SC1%REACTOME DATABASE ID RELEASE 57%193670 p75NTR negatively regulates cell cycle via SC1 18049 72843 433759 18053 15182 15183 SHC-MEDIATED CASCADE:FGFR4%REACTOME DATABASE ID RELEASE 57%5654719 SHC-mediated cascade:FGFR4 19247 107971 327826 83379 18176 20662 64654 14170 14173 80903 14164 14172 80857 14180 16653 15461 14186 14175 14177 DEFECTIVE B4GALT1 CAUSES B4GALT1-CDG (CDG-2D)%REACTOME DATABASE ID RELEASE 57%3656244 Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) 14264 18295 27047 116847 16545 17022 REMOVAL OF LICENSING FACTORS FROM ORIGINS%REACTOME DATABASE ID RELEASE 57%69300 Removal of licensing factors from origins 70024 19186 19188 57296 67151 66413 19185 66998 53380 18392 19192 26428 18393 26445 17463 26429 19166 69077 12576 26444 26446 26443 19645 12575 12566 22123 59029 19184 22190 19179 20422 57441 667035 56371 19182 12427 19181 23997 66997 16913 228769 50793 19175 70247 19177 67089 19170 21762 23996 17215 17219 103554 17217 16912 56452 19173 66634 19172 67177 73902 19167 26441 23834 19171 17216 26442 26440 17220 12428 17218 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE%REACTOME DATABASE ID RELEASE 57%174414 Processive synthesis on the C-strand of the telomere 327762 67967 16881 14156 18972 68275 18538 19891 69745 68240 18971 TRAIL SIGNALING%REACTOME DATABASE ID RELEASE 57%75158 TRAIL signaling 14082 21933 12633 22035 12370 LEUKOTRIENE RECEPTORS%REACTOME%R-HSA-391906.1 Leukotriene receptors 16995 58861 70086 57260 574402 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1%REACTOME%R-HSA-69229.1 Ubiquitin-dependent degradation of Cyclin D1 59029 19184 19179 22190 20422 19186 19188 667035 19182 19181 57296 23997 67151 66997 66413 19185 66998 12567 53380 16913 12443 228769 19192 70247 19175 19177 67089 26445 17463 19166 19170 69077 21762 23996 103554 16912 26444 26446 19173 26443 19172 73902 19167 26441 19171 26442 26440 22123 ELECTRIC TRANSMISSION ACROSS GAP JUNCTIONS%REACTOME%R-HSA-112303.1 Electric Transmission Across Gap Junctions 14615 14617 55991 14610 406218 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 57%354194 GRB2:SOS provides linkage to MAPK signaling for Integrins 16416 54519 16399 21894 109905 22371 14161 20662 14268 215449 110135 14083 99571 TP53 REGULATES METABOLIC GENES%REACTOME%R-HSA-5628897.3 TP53 Regulates Metabolic Genes 76850 236511 100039786 108099 19079 108097 319801 19082 14776 83409 22061 55948 670717 12868 22059 22631 22629 22628 74370 230784 17992 22166 17710 56717 22084 17709 14751 70207 239528 20463 231430 52892 17708 12861 12857 213988 21672 11652 110323 11651 20930 216456 22627 100041785 66142 66379 12858 14660 72416 108079 64930 241113 66359 217351 54401 233833 66096 23797 56716 214150 382985 74747 50493 54170 245670 545987 18477 68576 19211 75747 68441 66508 52187 17454 66272 14381 105787 69802 PHOSPHO-PLA2 PATHWAY%REACTOME%R-HSA-111995.1 phospho-PLA2 pathway 18783 26413 GSD IV%REACTOME DATABASE ID RELEASE 57%3878781 GSD IV 27357 232493 14936 THE ACTIVATION OF ARYLSULFATASES%REACTOME DATABASE ID RELEASE 57%1663150 The activation of arylsulfatases 58911 74008 545260 67902 271970 77041 11881 11883 GAP JUNCTION TRAFFICKING%REACTOME DATABASE ID RELEASE 57%190828 Gap junction trafficking 14620 14617 14622 14616 14618 14619 14613 14611 67300 13429 225152 14621 14612 353155 14615 74325 17920 12757 13132 14610 11773 13430 118454 14609 14623 NA+-DEPENDENT GLUCOSE TRANSPORTERS%REACTOME DATABASE ID RELEASE 57%428808 Na+-dependent glucose transporters 20537 64452 230612 246787 72045 53881 ION TRANSPORT BY P-TYPE ATPASES%REACTOME%R-HSA-936837.2 Ion transport by P-type ATPases 72621 320940 74772 57780 59095 66388 109552 268878 11945 11944 11941 231287 235574 11977 50770 224079 54667 11982 54670 108017 12323 108058 12322 56188 11931 11981 319767 11979 11928 50769 69047 50771 232975 98660 192113 76295 170759 640703 67331 12325 11932 11938 53313 11937 11980 381290 320707 67972 11933 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES%REACTOME DATABASE ID RELEASE 57%1650814 Collagen biosynthesis and modifying enzymes 12827 329941 140709 12829 12816 12839 237759 77018 94216 18453 12822 18542 12830 12835 12832 12833 12817 12831 12828 12837 12826 12153 213945 12821 18452 12819 269132 107581 12842 26433 69700 56401 12825 210530 12406 26432 330119 73368 320452 56693 18451 216725 14789 19035 234407 76477 18822 12818 21892 24087 12823 12843 12840 12834 245026 237360 12836 12841 373864 12824 71355 12815 53867 12814 12813 METHIONINE SALVAGE PATHWAY%REACTOME DATABASE ID RELEASE 57%1237112 Methionine salvage pathway 67870 56369 66902 67873 14718 104923 PKA-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%R-HSA-111931.1 PKA-mediated phosphorylation of CREB 19088 18749 210044 432530 224129 11513 11512 104111 12912 640703 11515 11514 104110 19087 19085 19084 18747 SYNTHESIS OF PC%REACTOME DATABASE ID RELEASE 57%1483191 Synthesis of PC 12651 13026 18618 212862 242259 68682 12660 99712 70129 11423 14245 236899 64899 237928 64898 100434 213603 12038 106861 12647 HEME DEGRADATION%REACTOME%R-HSA-189483.1 Heme degradation 394436 15368 15369 394433 233016 109778 TYPE I HEMIDESMOSOME ASSEMBLY%REACTOME%R-HSA-446107.1 Type I hemidesmosome assembly 12821 16774 16782 16780 12476 16403 18810 192897 DECTIN-2 FAMILY%REACTOME%R-HSA-5621480.1 Dectin-2 family 234779 17096 56620 14127 20963 381809 14360 56619 17474 26888 RORA ACTIVATES GENE EXPRESSION%REACTOME DATABASE ID RELEASE 57%1368082 RORA activates gene expression 12914 56406 217166 20185 12894 328572 11865 109151 81004 19017 18143 229003 19013 21372 19014 15183 268903 20787 66993 12753 19883 93759 59035 17978 20181 17977 SULFUR AMINO ACID METABOLISM%REACTOME DATABASE ID RELEASE 57%1614635 Sulfur amino acid metabolism 67870 56369 27376 107869 12411 67873 238505 210009 104923 66902 14718 12116 14630 22117 269378 14629 11720 211488 12583 211389 66071 66054 246277 64918 59010 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN%REACTOME DATABASE ID RELEASE 57%446193 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein 12764 20452 241159 19025 19703 67311 235504 75540 320438 50798 14584 331026 20448 69080 66789 26938 109785 14583 227697 54128 56737 24070 29858 380959 240119 107652 13481 74091 13480 234730 218138 381903 18010 56174 54342 20447 12091 23956 20446 57357 67422 102580 245847 110119 13478 66248 66174 50935 24060 328370 20454 192156 20451 50877 228368 22122 68563 225742 54613 20450 207958 52014 57170 241230 20449 208624 20442 20445 20443 69064 208211 20440 20444 94181 IRF3 MEDIATED ACTIVATION OF TYPE 1 IFN%REACTOME%R-HSA-1606341.1 IRF3 mediated activation of type 1 IFN 72512 56480 207521 54131 446099 58203 SODIUM-COUPLED PHOSPHATE COTRANSPORTERS%REACTOME DATABASE ID RELEASE 57%427652 Sodium-coupled phosphate cotransporters 20515 20531 142681 20516 20505 DEFECTS IN COBALAMIN (B12) METABOLISM%REACTOME DATABASE ID RELEASE 57%3296469 Defects in cobalamin (B12) metabolism 17850 14603 93835 21452 65969 109136 54219 109129 238505 67096 210009 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATION FROM THE CENTROSOME%REACTOME%R-HSA-380284.1 Loss of proteins required for interphase microtubule organization from the centrosome 19088 76816 18817 56455 76478 71909 219072 214552 237222 20873 18536 104318 22145 73738 26370 74470 219103 17997 99100 74360 68121 18472 27373 12009 13589 54130 76707 230376 22628 66296 236266 78887 18005 15519 381644 22154 225745 12534 214444 28135 231123 13427 13424 83922 208518 75786 18541 103733 101565 78177 69654 22153 225659 227613 16328 53598 22142 68475 22627 51792 18747 100986 75296 POST-CHAPERONIN TUBULIN FOLDING PATHWAY%REACTOME%R-HSA-389977.1 Post-chaperonin tubulin folding pathway 21371 545486 22153 72726 238463 73710 227613 66411 22143 22151 22147 67951 22142 22146 53857 22152 56327 70430 108903 22145 SIGNALING BY SCF-KIT%REACTOME DATABASE ID RELEASE 57%1433557 Signaling by SCF-KIT 12402 16923 17096 17444 56438 19353 26395 67603 319520 12703 23921 235584 26403 16416 12223 54519 100042150 21894 11600 19060 19186 19188 327826 17169 194231 109905 14161 226525 57296 67151 215449 18710 19185 66998 53380 14172 17967 15461 17463 83409 69077 29875 12912 26417 26413 12323 108058 12322 18015 59029 19197 19417 19184 19179 22190 20422 171463 667035 14573 19182 16590 240057 19181 64654 231474 14173 80903 14164 23997 66997 18039 218397 17395 110135 14585 20848 14178 80857 228769 14180 70247 67089 20846 14586 14587 14175 21762 14177 23996 20416 11876 14165 20851 26554 18596 20850 109880 14389 16399 54153 18708 15200 640703 18706 18673 12325 16818 16706 69601 83379 22371 73902 233046 114716 12981 19415 63953 14174 12982 19252 14159 16653 12649 12984 240672 13537 12988 21682 67836 16186 13385 14588 211323 16184 11836 18188 20740 20739 13645 16185 16452 216869 109689 18176 72399 70686 114715 240168 14268 66413 211255 18183 14083 16451 19192 16453 26445 19166 18218 15170 12576 14812 76089 26444 26446 14811 26443 14813 17228 19414 80297 14814 12575 74769 16183 20742 18707 18709 20741 21687 20743 16367 13866 14810 16192 26396 14360 16191 216148 114713 14186 19418 22123 20662 19052 14170 19053 19262 73699 640524 16913 75590 19175 19177 51792 19713 19170 22330 99571 13874 103554 16912 54401 83961 56637 16188 19173 19172 21770 107971 26932 100986 226849 18611 23980 20418 26931 320484 225849 384783 12675 245684 67112 110157 19167 26441 19419 11472 19171 545987 13649 70727 18595 26442 26440 101809 18591 18750 16334 76850 236511 19247 16337 75778 15370 12519 12524 606496 14783 54607 244650 12015 56717 22084 77647 239528 14786 12371 98432 117150 56458 56484 213988 11652 71520 18717 12478 14158 11651 15937 22612 19273 78757 228775 12487 217351 233833 23797 67605 18720 17246 56716 18719 214150 108083 18607 14388 22324 19211 227743 18718 109270 17454 58988 XAV939 INHIBITS TANKYRASE, STABILIZING AXIN%REACTOME DATABASE ID RELEASE 57%5545619 XAV939 inhibits tankyrase, stabilizing AXIN 21951 74493 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY%REACTOME%R-HSA-918233.1 TRAF3-dependent IRF activation pathway 56480 12914 54123 328572 56489 71956 22031 228607 71586 15977 54131 217069 66641 230073 PLC-MEDIATED HYDROLYSIS OF PIP2%REACTOME%R-HSA-139943.1 PLC-mediated hydrolysis of PIP2 234779 14726 56760 20963 ACTIVATION OF AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 57%399710 Activation of AMPA receptors 53623 14799 14802 14800 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL%REACTOME DATABASE ID RELEASE 57%1855204 Synthesis of IP3 and IP4 in the cytosol 18796 228550 18795 320404 74055 269437 18799 217837 104759 18803 234779 104015 18798 18797 16331 320634 16332 640703 16330 72469 18802 19211 233011 269615 114875 INTERFERON GAMMA SIGNALING%REACTOME DATABASE ID RELEASE 57%877300 Interferon gamma signaling 18753 19247 16362 16452 54131 12010 16451 17967 12702 15170 14991 18854 16363 240095 15007 12505 14960 14968 14969 12323 15979 108058 14469 12322 360213 54123 224762 15978 16364 15980 15894 20821 15006 74735 14129 80890 246727 93679 229644 23960 217069 246728 667803 236573 56631 12703 101700 15900 55932 231655 22329 229898 16391 319236 19824 17318 19204 22670 229900 66854 67525 55992 12325 17750 94088 56469 214158 65972 12265 19246 54139 27056 TRANSPORT OF CONNEXONS TO THE PLASMA MEMBRANE%REACTOME%R-HSA-190872.1 Transport of connexons to the plasma membrane 14609 14619 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS%REACTOME%R-HSA-174417.2 Telomere C-strand (Lagging Strand) Synthesis 18973 19687 69263 327762 67967 16881 19718 18969 14156 19075 18972 18538 19891 69745 68240 18971 59001 72151 106344 66979 18974 68275 18968 19076 INHIBITION OF ADENYLATE CYCLASE PATHWAY%REACTOME DATABASE ID RELEASE 57%997269 Inhibition of adenylate cyclase pathway 210044 432530 224129 11513 11512 104111 11515 11514 104110 14678 14677 14679 242851 14680 THE PHOTOTRANSDUCTION CASCADE%REACTOME%R-HSA-2514856.1 The phototransduction cascade 18750 14272 107477 243923 18107 14688 14699 18108 18761 640703 18587 225600 245650 214111 19674 18588 14919 56307 237178 14685 24013 110606 20215 75624 12788 212541 14913 73582 ERYTHROCYTES TAKE UP CARBON DIOXIDE AND RELEASE OXYGEN%REACTOME%R-HSA-1237044.2 Erythrocytes take up carbon dioxide and release oxygen 230582 12349 266690 320635 12351 72017 20533 11826 15122 15129 12346 19743 POU5F1 (OCT4), SOX2, NANOG ACTIVATE GENES RELATED TO PROLIFERATION%REACTOME%R-HSA-2892247.2 POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation 14173 620395 20674 99377 15221 18999 22773 100038891 58198 20848 13835 CYTOSOLIC SULFONATION OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 57%156584 Cytosolic sulfonation of small molecules 231583 23972 29859 23971 108652 23827 56362 20887 20860 20859 73836 76491 13521 INTEGRIN CELL SURFACE INTERACTIONS%REACTOME DATABASE ID RELEASE 57%216083 Integrin cell surface interactions 12827 104099 16416 12829 16402 12839 13138 237759 12822 11603 12817 12828 12826 14161 14268 16542 17022 381924 319480 12845 15891 109700 12505 107581 16421 16420 16408 67374 20750 15894 78369 320910 21825 241226 110135 14118 16404 16407 16423 16401 16400 12550 22329 99571 15530 12840 16409 22370 16403 16399 16398 16414 15896 12841 12215 16419 16411 83964 18613 213119 15898 16412 16456 16410 21923 RHO GTPASES ACTIVATE PAKS%REACTOME DATABASE ID RELEASE 57%5627123 RHO GTPases activate PAKs 192176 19353 17931 640703 16885 71960 19046 67938 17886 17880 18481 13043 329251 18016 18479 77579 67268 107589 17904 224105 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%R-HSA-3359462.1 Defective AMN causes hereditary megaloblastic anemia 1 14603 93835 65969 CHL1 INTERACTIONS%REACTOME DATABASE ID RELEASE 57%447041 CHL1 interactions 109700 18186 12661 16398 213119 15481 53870 16412 11733 BUDDING%REACTOME%R-HSA-168302.1 Budding ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP)%REACTOME DATABASE ID RELEASE 57%2426168 Activation of gene expression by SREBF (SREBP) 100705 13360 12914 56406 14732 18045 20775 109151 81004 170439 110196 68603 14137 192156 14104 100040592 19013 20683 20249 229003 21372 17855 19014 17764 66993 73166 14593 16987 59035 17978 20788 319554 107476 18046 235293 20181 13121 17977 18044 SIGNALING BY NOTCH3%REACTOME DATABASE ID RELEASE 57%1980148 Signaling by NOTCH3 19165 59287 54485 11487 100039623 13388 16450 100042305 208117 16449 18131 REGULATION OF SIGNALING BY CBL%REACTOME DATABASE ID RELEASE 57%912631 Regulation of signaling by CBL 15162 17096 17060 20963 18708 18706 12929 74769 12402 18707 18709 107746 22324 18710 12928 22612 14360 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX%REACTOME DATABASE ID RELEASE 57%195253 Degradation of beta-catenin by the destruction complex 14296 19186 212398 19188 13016 13017 57296 67151 66413 19185 66998 53380 19192 26445 17463 19166 69077 26444 12234 26446 433759 26443 26965 56438 21416 22123 59029 19184 19179 22190 21888 20422 21885 667035 21886 19182 19181 19052 19053 23997 73699 66997 21402 16913 228769 70247 19175 51792 67089 19177 19170 21762 23996 103554 16912 11789 56637 93687 72345 19173 21770 19172 21414 26932 16842 226849 14797 21415 12387 12005 26931 225849 21887 73902 19167 26441 19171 26442 26440 PHOSPHATE BOND HYDROLYSIS BY NTPDASE PROTEINS%REACTOME%R-HSA-8850843.1 Phosphate bond hydrolysis by NTPDase proteins 215446 93685 12495 12497 12496 67464 72090 12499 LRR FLII-INTERACTING PROTEIN 1 (LRRFIP1) ACTIVATES TYPE I IFN PRODUCTION%REACTOME%R-HSA-3134973.1 LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production 12914 54131 328572 12387 BICARBONATE TRANSPORTERS%REACTOME%R-HSA-425381.1 Bicarbonate transporters 20536 20535 54403 240215 20533 59033 94229 218756 232156 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR3%REACTOME DATABASE ID RELEASE 57%1839130 Signaling by activated point mutants of FGFR3 64654 80903 14173 14164 14184 14172 80857 14180 14175 SIGNALLING TO ERKS%REACTOME DATABASE ID RELEASE 57%187687 Signalling to ERKs 56438 26395 67603 319520 77480 102626 235584 26403 16416 12223 54519 100042150 21894 11600 19060 19186 19188 327826 17169 194231 109905 14161 226525 57296 67151 215449 19185 66998 53380 14172 17967 15461 17463 83409 69077 29875 17164 26417 26413 12323 108058 12322 18015 59029 19197 19417 19184 19179 22190 20422 171463 14573 667035 19182 16590 240057 19181 231474 64654 80903 14173 23997 14164 66997 18039 218397 110135 14585 14178 80857 228769 14180 70247 67089 14586 14587 14175 21762 14177 23996 20416 11876 14165 26554 18596 109880 16399 54153 15200 640703 18673 12325 16706 69601 83379 22371 73902 233046 114716 12981 19415 63953 14174 12982 19252 16653 12984 240672 13537 12988 67836 16186 13385 14588 211323 16184 11836 18188 20740 20739 13645 16185 16452 216869 109689 18176 18049 72399 70686 18211 114715 240168 14268 66413 211255 18183 14083 16451 19192 16453 26445 19166 56044 18218 14812 76089 26444 26446 14811 26443 14813 19414 80297 14814 16183 20742 20741 21687 20743 16367 13866 14810 16192 26396 14360 16191 216148 114713 14186 19418 22123 20662 19052 14170 19053 19262 73699 640524 16913 75590 19175 19177 51792 19713 19170 22330 99571 13874 103554 16912 26416 54401 83961 16188 19173 19172 21770 107971 26932 100986 226849 18611 23980 20418 26931 320484 225849 384783 245684 67112 110157 19167 26441 19419 11472 19171 545987 13649 70727 18595 26442 26440 101809 18591 29857 19094 26415 12929 18803 19730 12928 19769 19762 64143 107746 HS-GAG BIOSYNTHESIS%REACTOME%R-HSA-2022928.1 HS-GAG biosynthesis 14734 15478 15476 195646 20971 17423 103978 50787 20969 70484 64580 11603 93683 50786 71951 23888 15530 328779 628779 14735 15531 23908 319415 83398 20970 50785 54710 15529 14733 14043 14042 TANDEM PORE DOMAIN POTASSIUM CHANNELS%REACTOME DATABASE ID RELEASE 57%1296346 Tandem pore domain potassium channels 223604 52150 16530 332396 16525 217826 72258 16528 16526 16527 74571 SIGNALING BY FGFR2 IIIA TM%REACTOME DATABASE ID RELEASE 57%8851708 Signaling by FGFR2 IIIa TM 67710 17749 14183 66420 245841 20021 69241 68092 14173 14164 69833 433702 68705 20022 69920 231329 98053 100043714 20020 METABOLIC DISORDERS OF BIOLOGICAL OXIDATION ENZYMES%REACTOME%R-HSA-5579029.1 Metabolic disorders of biological oxidation enzymes 68165 14148 14149 13070 17200 18976 COPII (COAT PROTEIN 2) MEDIATED VESICLE TRANSPORT%REACTOME%R-HSA-204005.3 COPII (Coat Protein 2) Mediated Vesicle Transport 27096 20334 235416 66890 100042773 11839 218811 333883 76510 12793 193813 19324 77371 104318 245828 21787 20333 20703 18195 78232 69162 67231 12068 56041 56389 52036 76983 66682 67091 14799 99683 56418 74498 66226 110379 207352 99412 76308 89867 215474 56494 67857 50907 227648 13032 64138 108123 60409 69608 108124 66397 214895 21802 12794 59005 216131 243819 70361 12836 72978 105522 14275 317717 14069 100042343 17957 67727 14067 LAGGING STRAND SYNTHESIS%REACTOME%R-HSA-69186.1 Lagging Strand Synthesis 19687 69263 327762 67967 16881 19718 18969 14156 19075 18972 18538 19891 69745 68240 18971 72151 106344 68275 18968 19076 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 57%2474795 Diseases associated with visual transduction 19659 14539 12057 22139 242864 19662 19771 20897 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING%REACTOME DATABASE ID RELEASE 57%451326 Activation of Kainate Receptors upon glutamate binding 18796 13385 18795 14805 14806 14706 14696 110637 13383 14688 14708 14693 18797 14709 14697 14699 66066 14700 14701 14695 640703 53310 14704 14702 14809 14710 64337 14807 52589 REDUCTION OF CYTOSOLIC CA++ LEVELS%REACTOME%R-HSA-418359.1 Reduction of cytosolic Ca++ levels 11938 110891 53313 109552 11937 110893 381290 640703 320707 20541 67972 11941 PRESYNAPTIC PHASE OF HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME%R-HSA-5693616.1 Presynaptic phase of homologous DNA pairing and strand exchange 17535 69263 12021 19718 19891 68240 12189 11920 231724 237911 12190 327762 19364 21975 19360 19355 235610 114714 57434 81601 19363 19367 225182 19361 27354 72151 15574 106344 22427 68275 19356 12144 12649 26909 235559 LATE PHASE OF HIV LIFE CYCLE%REACTOME DATABASE ID RELEASE 57%162599 Late Phase of HIV Life Cycle 194309 67897 66914 24018 68776 18550 66464 83814 235459 107305 209361 66467 18571 20833 99730 319944 18107 24074 108143 229906 100088 83602 270627 20924 20922 75608 66201 14884 76959 228980 12572 216185 17420 268373 107951 330192 20479 21374 12454 114741 24116 19385 68953 66671 52348 66700 18108 22088 68153 74197 23894 57314 27632 116733 226182 105513 103573 13871 13872 58202 209357 208092 14885 13716 72504 67655 21343 66371 407786 67923 27224 72949 19384 12455 21399 218210 66679 18226 67710 69912 17749 66420 245841 227720 54563 223921 103468 70699 20021 69241 72787 269113 231042 234865 69736 19069 107939 170762 59015 227699 68092 69833 18141 68705 433702 20022 69920 445007 231329 98053 108989 19386 100043714 20020 69482 71805 22190 667035 UNCOATING OF THE INFLUENZA VIRION%REACTOME DATABASE ID RELEASE 57%168336 Uncoating of the Influenza Virion A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS%REACTOME DATABASE ID RELEASE 57%1971475 A tetrasaccharide linker sequence is required for GAG synthesis 14734 13003 12032 103978 20971 20969 11603 76898 72727 71951 217119 23888 15530 218271 233781 14735 280645 20970 121021 15529 117592 13004 12111 29873 14733 13179 OVARIAN TUMOR DOMAIN PROTEASES%REACTOME%R-HSA-5689896.1 Ovarian tumor domain proteases 57783 107607 68149 229603 170711 11848 22190 54644 22031 667035 192656 19766 21929 228607 269523 216080 217069 22034 13982 66889 226418 11789 22059 71956 414084 107260 231130 71586 16151 257632 360216 230073 ALPHA-OXIDATION OF PHYTANATE%REACTOME%R-HSA-389599.1 Alpha-oxidation of phytanate 16922 20524 26458 56794 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA%REACTOME DATABASE ID RELEASE 57%3359485 Defective CD320 causes methylmalonic aciduria 21452 54219 SULFIDE OXIDATION TO SULFATE%REACTOME%R-HSA-1614517.1 Sulfide oxidation to sulfate 211389 66071 27376 59010 22117 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME DATABASE ID RELEASE 57%427359 SIRT1 negatively regulates rRNA Expression 21341 21340 15267 319183 21374 319181 319182 319178 319186 319190 232440 75316 21339 319168 20937 382522 319167 319176 93759 624153 625328 51788 15077 319188 101867 15270 319149 78303 319169 NRCAM INTERACTIONS%REACTOME DATABASE ID RELEASE 57%447038 NrCAM interactions 13385 13383 319504 18187 53310 11733 21367 NRAGE SIGNALS DEATH THROUGH JNK%REACTOME DATABASE ID RELEASE 57%193648 NRAGE signals death through JNK 12015 19353 54126 236915 20662 18049 545156 26419 224014 269608 101497 13605 94275 75547 71704 26382 213498 16800 16443 102098 277360 226970 207212 57257 20663 73341 56349 18053 12125 171207 24001 22325 223435 109904 56321 22324 109934 69632 30938 21844 17207 230972 213649 53972 19418 14163 REGULATION OF CYTOSKELETAL REMODELING AND CELL SPREADING BY IPP COMPLEX COMPONENTS%REACTOME%R-HSA-446388.1 Regulation of cytoskeletal remodeling and cell spreading by IPP complex components 21754 57342 109711 73341 20163 170736 19303 CREB PHOSPHORYLATION%REACTOME DATABASE ID RELEASE 57%199920 CREB phosphorylation 100040260 110651 73086 17164 20111 12912 20112 SIGNALING BY FGFR2 AMPLIFICATION MUTANTS%REACTOME DATABASE ID RELEASE 57%2023837 Signaling by FGFR2 amplification mutants 14183 RECYCLING OF EIF2:GDP%REACTOME DATABASE ID RELEASE 57%72731 Recycling of eIF2:GDP 209354 26905 13665 13667 217715 108067 67204 224045 LYSOSPHINGOLIPID AND LPA RECEPTORS%REACTOME DATABASE ID RELEASE 57%419408 Lysosphingolipid and LPA receptors 229791 235044 272031 14739 65086 381810 14745 75769 13610 13609 94226 13611 53978 216152 HOMOLOGY DIRECTED REPAIR%REACTOME DATABASE ID RELEASE 57%5693538 Homology Directed Repair 18973 19687 69263 67967 19718 18972 18538 19891 69745 68240 18971 27015 80905 77782 11350 59001 72151 106344 66979 18974 68275 22594 16882 100043429 93765 26909 17535 12021 319181 70620 15204 70681 240087 74335 12189 11920 231724 382522 237911 70238 210766 327762 11545 27223 14156 21975 11546 19355 20184 19367 12566 269582 59004 22427 19356 12144 235559 319183 22190 319182 319178 319186 667035 319190 12427 107823 12190 52864 233826 22196 268465 50505 19364 19360 13870 19365 235610 114714 107976 57434 319152 224008 68251 209334 19362 81601 71711 19363 225182 269400 19361 27354 15574 19822 319188 232314 15270 12649 78303 56420 66131 12428 21853 50721 NEGATIVE REGULATION OF FGFR2 SIGNALING%REACTOME%R-HSA-5654727.1 Negative regulation of FGFR2 signaling 19247 22190 17346 667035 327826 12402 24064 64654 19052 14173 80903 19053 14164 14178 14172 80857 14180 51792 14175 14177 14165 109880 26417 26413 67112 14174 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF UNSATURATED FATTY ACIDS%REACTOME%R-HSA-77288.1 mitochondrial fatty acid beta-oxidation of unsaturated fatty acids 11364 231086 13177 67460 97212 11363 RESOLUTION OF D-LOOP STRUCTURES THROUGH HOLLIDAY JUNCTION INTERMEDIATES%REACTOME DATABASE ID RELEASE 57%5693568 Resolution of D-loop Structures through Holliday Junction Intermediates 17535 12021 74335 12189 11920 237911 12190 52864 233826 327762 268465 19364 21975 19360 114714 57434 224008 209334 81601 19362 71711 19363 225182 27354 19361 22427 26909 12144 IRS-MEDIATED SIGNALLING%REACTOME%R-HSA-112399.1 IRS-mediated signalling 667739 56438 26395 67603 319520 13684 75705 19042 64930 12283 72149 13631 66096 13685 54170 245670 68576 20869 68441 66508 227154 52187 69008 235584 105787 26403 16416 12223 54519 100042150 21894 11600 19060 19186 19188 327826 17169 194231 109905 14161 226525 57296 67151 215449 19185 66998 53380 14172 17967 15461 17463 83409 69077 29875 26417 26413 208643 12323 108058 12322 18015 59029 19197 19417 19184 19179 22190 20422 171463 14573 667035 19182 16590 240057 19181 231474 64654 80903 14173 23997 14164 66997 18039 218397 110135 14585 14178 80857 228769 14180 70247 67089 14586 14587 14175 21762 14177 23996 20416 11876 14165 26554 18596 109880 16399 18708 54153 15200 640703 18706 18673 12325 16706 69601 83379 22371 73902 233046 114716 12981 19415 63953 14174 12982 19252 16653 12984 240672 13537 12988 67836 16186 13385 14588 211323 16184 11836 18188 20740 20739 13645 16185 16452 216869 109689 18176 72399 70686 114715 240168 14268 66413 211255 18183 14083 16451 19192 16453 26445 19166 18218 14812 76089 26444 26446 14811 26443 14813 19414 80297 14814 74769 16183 20742 18709 20741 21687 20743 16367 13866 14810 16192 26396 14360 16191 216148 114713 14186 19418 22123 20662 19052 14170 19053 19262 73699 640524 16913 75590 19175 19177 51792 19713 19170 22330 99571 13874 108079 103554 241113 16912 54401 83961 16188 19173 19172 21770 107971 26932 100986 226849 18611 23980 20418 26931 320484 225849 384783 245684 67112 110157 19167 26441 19419 11472 19171 545987 13649 70727 18595 26442 26440 101809 18591 19247 75778 108099 19079 108097 19082 74370 81897 56717 22084 75669 225326 11652 11651 228775 18576 67605 56716 18607 14388 CROSS-PRESENTATION OF PARTICULATE EXOGENOUS ANTIGENS (PHAGOSOMES)%REACTOME DATABASE ID RELEASE 57%1236973 Cross-presentation of particulate exogenous antigens (phagosomes) 13058 17970 17972 16419 17969 13057 16410 12491 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKK%REACTOME%R-HSA-442717.1 CREB phosphorylation through the activation of CaMKK 55984 12326 12912 640703 REGULATION OF PAK-2P34 ACTIVITY BY PS-GAP RHG10%REACTOME%R-HSA-211728.1 Regulation of PAK-2p34 activity by PS-GAP RHG10 78514 224105 WNT5A-DEPENDENT INTERNALIZATION OF FZD4%REACTOME DATABASE ID RELEASE 57%5099900 WNT5A-dependent internalization of FZD4 18750 13543 74325 22418 12757 11772 232910 18752 11773 216869 11771 18751 71770 67300 14366 ACTIVATION OF CASPASES THROUGH APOPTOSOME-MEDIATED CLEAVAGE%REACTOME DATABASE ID RELEASE 57%111459 Activation of caspases through apoptosome-mediated cleavage 11783 12369 12367 670717 12371 HDR THROUGH HOMOLOGOUS RECOMBINATION (HR) OR SINGLE STRAND ANNEALING (SSA)%REACTOME%R-HSA-5693567.1 HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA) 18973 19687 69263 67967 19718 18972 18538 19891 69745 68240 18971 27015 80905 11350 59001 72151 106344 66979 18974 68275 100043429 93765 26909 17535 12021 319181 70620 15204 70681 240087 74335 12189 11920 231724 382522 237911 70238 210766 327762 27223 21975 19355 20184 19367 12566 269582 59004 22427 19356 12144 235559 319183 22190 319182 319178 319186 667035 319190 12427 107823 12190 52864 233826 268465 22196 50505 19360 13870 19365 19364 235610 114714 107976 57434 319152 224008 68251 209334 19362 81601 71711 19363 225182 269400 19361 27354 15574 19822 319188 232314 15270 12649 78303 56420 66131 12428 21853 50721 WNT LIGAND SECRETION IS ABROGATED BY THE PORCN INHIBITOR LGK974%REACTOME DATABASE ID RELEASE 57%5340573 WNT ligand secretion is abrogated by the PORCN inhibitor LGK974 53627 NEUROTRANSMITTER UPTAKE AND METABOLISM IN GLIAL CELLS%REACTOME DATABASE ID RELEASE 57%112313 Neurotransmitter uptake and Metabolism In Glial Cells 20512 20511 14645 105727 CIRCADIAN CLOCK%REACTOME%R-HSA-400253.1 Circadian Clock 18627 79362 56406 20893 18626 217166 13170 12894 382056 19377 109151 59027 19017 17261 19013 229003 104318 19014 14815 268903 20787 12234 27373 19045 26965 12912 93759 19883 11998 50789 19046 17978 19047 20181 17977 12914 11909 20185 17260 328572 15251 11865 22190 667035 81004 21402 18143 21372 15183 66993 12753 59035 14068 17691 12457 12952 18787 272322 12953 NIK-->NONCANONICAL NF-KB SIGNALING%REACTOME%R-HSA-5676590.1 NIK-->noncanonical NF-kB signaling 53859 19186 19188 57296 67151 66413 19185 66998 53380 19192 26445 17463 19166 69077 26444 12234 26446 26965 26443 22192 22123 22200 59029 19184 19179 22190 20422 667035 19182 19181 23997 66997 21402 16913 228769 70247 19175 67089 19177 103583 19170 21762 23996 103554 16912 19173 19172 12675 73902 19167 26441 19698 18034 19171 26442 26440 CYTOCHROME C-MEDIATED APOPTOTIC RESPONSE%REACTOME DATABASE ID RELEASE 57%111461 Cytochrome c-mediated apoptotic response 11783 12369 12367 670717 12371 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 57%211945 Phase 1 - Functionalization of compounds 56448 212503 13107 13087 13088 74134 13106 546726 13082 11668 13110 26876 232174 13077 13116 11522 14149 13070 19224 13075 106648 100040843 72054 19223 13122 110115 13074 17978 109731 104086 17161 20186 13072 13120 320997 20181 13079 631304 13124 13121 13118 21391 64385 17977 208285 622127 13078 545817 13081 244209 102294 13113 13114 13123 72082 13115 11669 107141 13076 71519 18976 72303 68165 14148 68021 14262 72535 14261 436059 69574 55990 76507 60525 13849 11532 11754 68738 11670 237940 11529 67758 104158 18984 56050 UREA CYCLE%REACTOME%R-HSA-70635.1 Urea cycle 11846 11898 18408 11847 217214 18416 109900 83885 67824 227231 GLUCAGON SIGNALING IN METABOLIC REGULATION%REACTOME%R-HSA-163359.1 Glucagon signaling in metabolic regulation 19088 224129 11513 11512 11515 11514 104110 14706 14696 14526 14527 14688 14708 14693 14709 18747 66066 18749 14700 14701 210044 432530 104111 14695 14704 14702 64337 19087 19085 19084 INTERCONVERSION OF 2-OXOGLUTARATE AND 2-HYDROXYGLUTARATE%REACTOME DATABASE ID RELEASE 57%880009 Interconversion of 2-oxoglutarate and 2-hydroxyglutarate 217666 98314 76187 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%R-HSA-176409.1 APC C:Cdc20 mediated degradation of mitotic proteins 66156 52206 668450 12237 19186 22194 19188 56150 75430 216080 57296 67151 66413 19185 66998 53380 52717 19192 26445 17463 19166 69077 26444 26446 26443 52563 99152 18005 12534 69957 68999 68612 17222 22123 59029 19184 19179 22190 12236 20422 667035 19182 12427 19181 23997 66997 16913 228769 19175 70247 19177 67089 19170 21762 23996 103554 16912 19173 19172 59008 56317 73902 19167 26441 107995 19171 217232 26442 26440 30939 12428 METABOLISM%REACTOME DATABASE ID RELEASE 57%1430728 Metabolism 26971 18784 14792 78390 218121 14245 18779 225845 18782 66350 329502 18778 271844 99010 26970 26565 217166 14149 13070 170460 64898 100042622 20845 68165 170459 11677 14148 80879 57274 20501 12215 64899 15129 14725 16971 66905 110959 74114 12908 80911 74121 11740 16211 433923 329416 13078 170749 20537 14385 14377 64452 231103 20526 56485 211006 65967 214580 75420 20226 107141 13076 71519 72303 20525 68401 230612 246787 14378 53881 20527 50493 11739 13077 14678 14677 18127 66394 233081 78830 13358 72157 230163 14447 27376 14751 14387 11674 74185 13853 102093 50799 12183 26384 14719 110094 18679 74551 110078 53412 14718 17449 18563 13806 110095 19309 18639 100043349 18640 170768 67863 13807 13808 18534 77559 14120 67980 18642 270198 18641 105193 56421 66681 21991 18655 72141 68961 14121 18682 27357 15275 15277 232493 14936 11676 18648 56012 212032 15122 28169 18783 20528 75612 192188 231327 11821 66706 229211 670717 12868 68202 17992 17710 66152 17711 17709 68472 75406 70207 69702 22272 20463 231430 76916 17708 69487 76826 17991 12857 54405 66091 104130 66841 110826 110842 73694 76947 100041785 68493 66142 12858 72416 17716 239760 66359 225887 66108 17721 66416 68375 66916 67130 78330 75597 67184 66414 623286 66218 67264 68342 100042503 226646 595136 72900 227197 68197 66377 66046 17995 17993 624814 66272 66445 69802 18663 103988 27369 108147 14450 14544 11717 109674 67054 23917 11564 22436 100042069 66355 237823 229665 11566 75894 11534 105446 76952 14775 76429 12359 229363 11486 15452 18950 11565 56448 13107 13087 13088 74134 13106 18971 14706 14696 14526 14527 20598 14688 14708 14693 14709 14697 76808 68028 240332 100043755 19899 67186 20115 57294 667739 67025 27370 65019 67248 666669 100038991 100038875 100040021 432502 66481 100040298 238217 56040 667618 19989 622127 545817 12491 223864 16500 238276 56508 26940 268345 240444 238076 14859 14699 54486 66066 69065 14700 68214 14701 68312 207182 23887 66447 14630 14695 14862 14873 14652 71522 14704 14865 14702 68044 14866 14710 68252 64337 14629 58810 14874 75475 14863 14854 66054 13885 100042314 14598 76263 14872 18984 14871 211666 56615 11846 67512 20810 55979 67870 99035 56369 56348 14732 19063 18045 12686 66775 18416 104112 67873 106529 671878 19186 231510 109900 19188 433256 83885 54397 67824 170439 227231 329910 104923 109905 14081 59027 14555 11898 94180 246703 30963 57296 67375 333433 67151 18408 78245 11847 14104 18710 66902 210992 19185 217214 13167 66998 78914 20249 53380 66454 74559 215456 67993 243078 226518 74205 17463 192185 56360 223646 74156 69077 74080 50790 29875 14626 68801 54326 66834 171210 171281 17164 69923 264895 83603 67800 14933 216739 15487 257633 55951 171282 70456 13350 381511 225010 217666 57874 109801 102247 235339 66198 72482 233549 98314 18046 107476 18604 68262 27273 70025 18597 68393 228026 70757 68263 328845 236900 52123 76187 18044 54325 382051 16828 27402 106557 16833 59029 16832 319518 19184 19179 20422 19182 266645 229905 19181 98256 70266 209176 23997 107766 66997 15930 70789 56720 23923 71562 228769 70247 67089 21762 23996 640703 16330 73902 665563 216188 109754 56406 109672 54338 68421 100039707 20493 28250 66413 28253 20494 76408 19192 26445 14776 19166 67768 16331 16332 26444 26446 26443 17979 74769 18707 18709 270685 20509 20522 108037 77697 17769 14360 67618 108156 107747 76701 19300 17768 22123 69906 56453 270669 16913 19175 19177 19170 103554 16912 19173 19172 19167 26441 19171 26442 26440 18750 19088 72621 16334 75778 104110 229709 11370 27053 12671 16770 224129 11513 11512 11515 11514 117150 18803 18717 11651 16440 228775 15183 18747 16438 18749 210044 102448 432530 67880 68631 104111 18720 24001 18719 108083 19087 19085 19084 19211 18718 16439 109151 80509 22173 14661 26912 30956 13166 209027 72560 13195 70337 107272 18242 18478 270076 212647 75613 66514 99439 94112 21823 234724 217593 11298 13370 13371 73748 19125 21743 236539 21372 216343 110391 13190 13180 107585 14219 14085 59024 18948 14204 104816 15445 327987 19193 11484 64918 19016 19013 19015 19014 68975 70625 234959 70208 264064 109731 17161 78923 171285 121021 74241 269941 58250 56771 13004 12111 29873 60322 77590 13179 234356 71797 14317 140483 74246 14635 59031 13003 20185 14430 53374 20602 78752 12032 233016 22190 76238 71761 109778 667035 243537 15109 107239 15186 15112 11611 623661 67164 14711 209692 70503 79464 69792 13142 20466 18708 269951 18706 15929 22117 20917 59035 211488 382985 66945 12583 14194 18293 56451 211389 66052 66071 170718 246277 78920 59010 11429 18115 12974 97064 13382 17448 20916 66925 67834 67680 57813 215446 23959 21877 13178 56749 50773 94215 103850 22245 22247 93685 22171 12495 103149 12497 67365 12496 268782 67464 76654 72090 72269 12499 80914 230582 64705 266690 22271 21677 72962 320635 69719 230718 99586 320685 229003 243616 14411 66358 214254 53893 75686 23989 69790 94284 394436 216558 28077 552899 100559 394433 71773 213012 231396 22236 22235 242585 100727 394434 11433 12914 230099 328572 635960 11637 110639 433968 18102 56520 19052 71884 19053 17118 73699 67725 21915 93692 81600 11636 55936 20683 51797 21428 66422 51792 20133 75456 107566 78801 68870 108079 110198 16434 53420 66588 66993 229949 14923 109652 21770 19139 68021 71670 14262 72535 22601 14261 436059 216154 69574 55990 76507 60525 13849 11532 11754 68738 11670 237940 11529 67758 104158 54391 18605 69698 319945 218210 66679 18226 69912 227720 54563 223921 103468 70699 72787 26379 19017 108099 108097 67279 69568 27973 71707 269113 231042 234865 69736 19069 107939 170762 19883 59015 66194 227699 235386 21990 18141 15233 22018 12971 214593 445007 69051 50880 108989 76282 19386 100678 69482 71805 67891 100042986 100042740 621100 100043295 67097 100043000 625646 67281 633683 666899 81004 16785 100039316 267019 100040970 21678 21679 21676 19941 26896 382492 20055 19951 100042670 51813 68193 665189 668182 19921 20044 668144 100043423 100043893 670832 100043876 629957 225058 22121 75617 667279 76846 27050 100043184 19934 100040331 100043391 319195 68172 241053 100043209 20102 67941 67381 27207 668668 20103 672214 14381 622534 20085 20084 12289 110948 110821 72039 12297 66904 330064 26363 78038 11603 19046 12352 12349 76459 12354 12351 71934 12353 56078 58866 226413 11722 100043686 69983 232714 20927 12346 23831 12350 212503 20229 16514 20519 14682 14675 14676 14672 320415 51793 114886 20751 68268 69219 18777 19286 14528 109791 58194 243168 68453 18550 23945 16204 103161 18453 11772 11425 14080 18553 21884 67717 19699 68523 320024 67563 11771 109006 93835 26426 71770 65969 11806 72199 11808 70166 241274 11770 56209 240633 66569 14079 50767 11303 26425 67469 78797 100102 233552 238055 26371 11807 13131 12140 239759 18552 18946 228859 69060 19045 218203 12757 232910 16890 15450 11773 110611 72947 75497 232345 16592 208677 103968 14077 16956 11814 68680 18947 66473 19047 22359 624219 57875 30924 16835 11816 171504 22259 27801 76483 22094 22260 12389 67470 67300 17777 27409 66397 100017 12613 69573 12683 11307 105847 16816 56636 16891 320981 68616 67674 233801 272428 107146 233799 435528 19384 15108 14603 100043508 19659 63857 65107 13081 79235 67861 244209 55938 19662 19660 13115 75669 239393 225326 170752 14473 19092 12296 12288 56305 269400 104458 226414 85305 107045 66143 11657 97541 13722 231872 107508 216443 105148 231583 14734 15118 15478 212898 15476 195646 15116 15926 17423 50787 70484 27029 64580 110006 23972 23971 20907 218271 328779 233781 628779 14735 338362 280645 80982 20544 114332 15531 23908 54371 319415 18807 83398 15519 108652 15587 12505 108902 53357 50785 15492 15212 15497 54710 12640 117592 13072 15211 27419 56398 16866 15586 13079 72136 14043 56773 545291 14042 11690 625249 17001 11689 15107 109685 93747 11364 22276 14151 70383 19044 11655 11656 319901 76969 15931 93683 27416 15442 50786 15117 76898 72727 73836 71951 15932 217119 23888 13521 73744 17160 110173 17159 20910 15288 15366 22275 12892 17025 226139 14733 103978 26457 237911 75320 28042 12651 102278 13026 18618 19210 212862 66586 71760 12660 66853 99712 66857 270084 236899 116939 105501 237928 232889 67452 668257 320951 14712 231086 66826 97212 106861 665270 218865 192289 17772 104709 97287 56752 20425 170442 12891 77582 226856 52858 66727 266692 110911 19062 27281 30955 27388 84095 70568 20975 68671 269180 114874 18705 245532 104015 74451 18704 74596 74302 74182 219135 110695 240752 66461 67073 192166 320207 67216 53332 237625 234515 74129 320634 12116 17748 17752 17750 17751 21881 21351 100705 12895 12896 57279 117147 68465 12894 11684 11450 72674 58805 546726 13082 11668 26876 232174 11522 17252 434437 68133 104174 12290 12286 14645 12038 56808 12012 26459 83702 13123 11423 11669 12846 224020 64436 103199 234129 107650 234729 83493 18711 242259 68682 70129 19743 69718 72469 17330 27399 100434 213603 18802 233011 212111 114663 56409 71207 269615 114875 75678 18796 228550 18795 320404 327655 271424 74055 76500 71780 102954 269437 227399 18799 217837 16329 55980 20698 14264 18295 18798 18797 27047 116847 16545 17022 269614 106564 19223 68591 13122 74450 268566 73132 69372 71743 75735 17434 211347 66812 17978 17117 104086 20186 170789 77337 26458 105349 101502 208665 20181 15488 13124 27413 93732 17977 104759 18805 234779 18806 73178 11761 216134 57423 11957 103711 11946 11947 432676 228033 17705 66043 68055 11949 100039108 227112 100041835 11950 11958 56327 19141 13430 22072 22318 20517 107869 12411 13113 13114 72082 20614 216456 14660 12647 20518 20869 72017 545260 57357 22166 225913 12040 12036 12039 12035 11992 104776 13171 105663 11826 12041 66885 243382 58875 66948 56357 227095 108143 116914 29807 15368 15369 26357 52466 18671 70316 232449 52892 19895 100040287 66646 67273 66495 12861 22273 17722 100042918 110323 68198 66694 20930 230075 67003 67530 17719 66379 17718 17717 18263 53814 13871 110208 66171 246696 380840 14297 67712 18104 18247 18245 54375 54219 109129 238505 67096 210009 106648 100040843 72054 269378 18113 29859 23827 11720 56362 17960 20887 22017 17961 57344 20860 13120 320997 232087 76491 631304 13118 21391 64385 208285 20971 20969 15530 22139 20135 13361 67895 74776 20970 15529 11842 11840 77371 11881 11883 67902 102294 21452 12709 76722 67092 102857 14431 12716 12715 19025 14311 11812 66113 11813 74011 22227 99683 20523 18010 22228 22229 23956 192156 50877 54613 20533 114479 64292 20773 545975 56632 78925 79554 109136 20775 96979 94224 67460 20933 245533 330450 54384 56690 110460 13110 56386 67528 57370 67219 56375 20524 53418 113868 15360 56336 100040592 111175 110446 19225 19224 13075 11409 17764 70750 272636 433323 103236 12850 74008 20597 170826 17250 58994 54447 98386 110115 13074 18181 11363 104725 76199 16993 78894 71985 227327 56185 14421 14420 74442 76267 227102 66612 66999 19731 13121 12091 73724 77626 208449 14595 110196 72297 14137 69608 13479 66469 19012 50784 18631 22239 75986 242669 67420 76303 67916 230379 58911 381379 12408 14667 14466 14073 30960 12753 12642 72999 14593 77041 16987 73690 17436 15356 338521 195733 13850 20788 70059 319554 56473 231070 11605 20859 228677 271970 14200 13177 81535 66844 67131 108098 13595 20280 20334 19156 18194 77116 74147 242083 94185 18670 218811 56491 15446 69772 66183 223753 11687 71365 14187 68603 52635 14571 13116 231727 76893 11520 234309 66190 20322 235582 11606 16548 238011 11886 108645 11551 11553 114664 13360 15483 15486 93898 11666 74754 53625 11865 15485 66172 107765 22234 171168 15484 20397 67260 208982 101490 71854 67041 319446 217707 268656 18143 52064 228061 17855 66065 56356 26378 18976 68865 14979 17850 67224 230027 71949 73166 78334 56794 71883 74159 23943 241447 13244 19215 14373 56075 16922 11688 11686 230101 75772 18760 235623 15490 20442 67103 20443 235293 66234 102632 56050 192191 67689 20444 71911 NEUROTRANSMITTER CLEARANCE IN THE SYNAPTIC CLEFT%REACTOME%R-HSA-112311.1 Neurotransmitter Clearance In The Synaptic Cleft 17161 12846 15567 20517 12038 13162 11423 11669 20518 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS%REACTOME%R-HSA-168928.1 RIG-I MDA5 mediated induction of IFN-alpha beta pathways 108086 54644 22031 16362 53323 100041766 228607 216080 230398 66105 15977 54131 74153 66641 18521 11596 20210 21353 56489 71956 16363 22030 74256 56480 12914 54123 56791 328572 100038882 434174 22190 14082 80861 26401 667035 12370 72162 19766 17874 21929 217069 11820 16396 22034 67526 20203 225913 52440 11793 23988 12675 19697 18033 18036 270151 18035 71586 16151 18034 16150 13211 230073 METABOLISM OF INGESTED H2SEO4 AND H2SEO3 INTO H2SE%REACTOME DATABASE ID RELEASE 57%2408550 Metabolism of ingested H2SeO4 and H2SeO3 into H2Se 50493 23972 23971 VEGF LIGAND-RECEPTOR INTERACTIONS%REACTOME%R-HSA-194313.1 VEGF ligand-receptor interactions 16542 22341 18654 22339 22340 14205 14254 14257 G2 PHASE%REACTOME DATABASE ID RELEASE 57%68911 G2 Phase 12566 13557 12427 12428 13555 SIGNAL ATTENUATION%REACTOME%R-HSA-74749.1 Signal attenuation 20662 20416 16334 16367 14783 16337 26417 26413 384783 REGULATION OF TP53 EXPRESSION AND DEGRADATION%REACTOME DATABASE ID RELEASE 57%6806003 Regulation of TP53 Expression and Degradation 53376 56717 22190 667035 13163 12427 19052 19053 73699 11652 17248 20393 11920 11651 78757 51792 67338 12578 80751 22059 23797 12450 17246 12142 26931 56716 18607 50883 12534 12566 252870 227743 109270 12428 THROMBOXANE SIGNALLING THROUGH TP RECEPTOR%REACTOME%R-HSA-428930.1 Thromboxane signalling through TP receptor 14699 14682 66066 14675 14700 21390 14701 14676 14672 14674 14695 14704 14702 14710 64337 14706 14696 14688 14708 14693 14709 14697 REPRESSION OF WNT TARGET GENES%REACTOME DATABASE ID RELEASE 57%4641265 Repression of WNT target genes 433759 21888 21414 14797 16842 12387 21415 21885 21886 21887 13016 13017 21416 TRANSPORT OF ORGANIC ANIONS%REACTOME DATABASE ID RELEASE 57%879518 Transport of organic anions 101488 24059 58807 28250 227394 28253 108115 11657 11998 G2 M CHECKPOINTS%REACTOME%R-HSA-69481.2 G2 M Checkpoints 69263 19718 19891 68240 66413 19192 26445 19166 26444 26446 26443 72151 106344 68275 22123 16913 50793 93765 19175 22627 19177 19170 103554 16912 54401 19173 19172 19167 26441 19171 26442 26909 26440 70024 17535 12021 22390 319181 19186 100039786 19188 70620 15204 70681 57296 240087 67151 27214 12189 19185 66998 11920 53380 18392 26428 18393 17463 26429 231724 69077 382522 237911 70238 210766 55948 327762 27223 21975 22059 19355 22631 22629 22628 20184 19367 12544 12545 12534 12566 269582 59004 22427 12442 19356 12144 235559 319183 59029 19184 22190 19179 319182 20422 319178 667035 319186 319190 19182 268930 107823 19181 23997 66997 228769 70247 67089 21762 23996 17215 17219 17217 29870 56452 19360 66634 235610 107976 319152 68251 81601 225182 27354 73902 15574 50883 23834 12532 12530 319188 17216 15270 12649 78303 17220 17218 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES)%REACTOME DATABASE ID RELEASE 57%1236978 Cross-presentation of soluble exogenous antigens (endosomes) 59029 19184 19179 20422 19186 19188 19182 14129 19181 57296 23997 67151 66997 66413 17533 246278 19185 17534 66998 53380 16913 228769 19192 70247 19175 67089 19177 26445 17463 19166 19170 69077 21762 23996 103554 16912 26444 26446 19173 26443 19172 73902 19167 26441 19171 26442 26440 22123 THREONINE CATABOLISM%REACTOME DATABASE ID RELEASE 57%8849175 Threonine catabolism 26912 RNA POLYMERASE III TRANSCRIPTION%REACTOME%R-HSA-74158.1 RNA Polymerase III Transcription 17749 21374 66420 245841 20841 20016 26939 70408 67486 18029 12909 18032 78929 20018 67065 67005 20823 18027 218832 69870 70428 74414 233863 227644 544971 75627 66596 102209 77634 71752 72308 330959 69833 66653 70239 269252 67371 100043714 98488 18986 PI METABOLISM%REACTOME DATABASE ID RELEASE 57%1483255 PI Metabolism 77116 11842 11840 54384 18710 241274 56209 66569 50767 233552 16331 16332 74769 18707 18709 17772 104709 97287 170749 117150 75669 225326 19062 101490 30955 84095 20975 269180 18705 18717 104015 18704 74302 219135 240752 67073 320207 53332 234515 320634 224020 64436 320981 103199 234129 68616 107650 234729 83493 18708 18711 18706 56305 18720 18719 108083 19211 18718 RHO GTPASE EFFECTORS%REACTOME DATABASE ID RELEASE 57%195258 RHO GTPase Effectors 13543 18817 67629 69928 17973 236930 68014 20430 18472 56378 208628 330319 57294 13589 52696 83767 76707 242687 67733 83815 76804 102920 11350 76464 320795 99982 19046 66570 83431 66713 11835 108911 18481 76499 18221 12617 75786 26886 66934 224105 19353 17931 14270 13057 13058 17970 12229 17972 17969 22627 22342 16563 16573 319181 12237 100039786 104215 56150 232943 382522 29875 55948 22631 22629 26417 22628 26413 13043 16319 320394 226747 66442 12615 319183 72155 108000 12236 60411 319182 625534 319178 319186 232987 319190 66468 67052 52504 67139 70385 71876 73470 70454 192176 12385 208846 17120 57778 20166 404710 13542 640703 13544 228421 16886 244495 107995 381318 12532 66336 67037 319188 216965 72415 15270 56430 16594 107589 78303 17904 66977 12235 13385 26951 14083 11799 12576 19047 11848 19052 19053 73699 51792 54401 16572 73804 21770 26932 74764 226849 12387 26931 103573 225849 229841 16593 319169 69912 17283 103468 232440 234865 69736 12638 233406 319176 16709 11854 20807 52276 56419 71960 59015 17978 20877 223701 624153 67938 625328 51788 15077 544963 381293 445007 67268 319149 19386 263803 110379 105855 19877 245880 94221 15267 50884 108100 56443 13367 68524 18643 11461 18645 16885 329165 14787 101314 237038 75669 52428 225326 19878 17886 56212 76884 109333 319168 18479 19354 80987 11852 68458 76709 71409 319167 12550 215280 71893 11465 73178 22379 22376 11853 68089 12704 74117 11308 224480 14026 67771 11867 100039683 18607 320271 17880 329251 18016 77579 76378 16412 241275 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX%REACTOME%R-HSA-69298.1 Association of licensing factors with the pre-replicative complex 67177 22190 13557 667035 57441 13555 23834 242705 18392 26428 50793 18393 26429 MGMT-MEDIATED DNA DAMAGE REVERSAL%REACTOME DATABASE ID RELEASE 57%5657655 MGMT-mediated DNA damage reversal 17314 ORGANIC ANION TRANSPORTERS%REACTOME DATABASE ID RELEASE 57%428643 Organic anion transporters 20504 216227 27376 140919 235504 114479 216225 MTOR SIGNALLING%REACTOME%R-HSA-165159.1 mTOR signalling 56717 22084 108099 19079 11652 108097 13684 19082 11651 83409 75705 19042 108079 64930 241113 12283 72149 54401 13631 66096 667739 67605 56716 74370 13685 54170 208643 245670 545987 68576 20869 68441 66508 227154 52187 69008 105787 ESTABLISHMENT OF SISTER CHROMATID COHESION%REACTOME%R-HSA-2468052.1 Establishment of Sister Chromatid Cohesion 71988 24061 77805 20842 20843 13006 67849 71521 19357 100710 218914 RAF ACTIVATION%REACTOME DATABASE ID RELEASE 57%5673000 RAF activation 26403 54401 109880 11836 21770 26932 226849 26395 18673 16452 26931 225849 17169 16706 18176 72399 19052 110157 19053 73699 26396 16653 15461 51792 PIWI-INTERACTING RNA (PIRNA) BIOGENESIS%REACTOME%R-HSA-5601884.1 PIWI-interacting RNA (piRNA) biogenesis 57746 67710 17749 98558 66420 245841 71981 20021 69241 94244 66715 13206 72634 74691 57749 15519 74068 69833 17864 330890 20022 210510 69920 231329 83561 100043714 20020 83456 RNA POLYMERASE II TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 57%75953 RNA Polymerase II Transcription Initiation 67710 68776 66464 21374 17749 66420 245841 235459 209361 66467 20021 69241 99730 319944 24074 108143 229906 83602 270627 14884 66671 228980 68153 74197 23894 12572 226182 216185 17420 13871 13872 209357 69833 14885 68705 72504 20022 69920 21343 231329 98053 407786 100043714 20020 REGULATION OF TP53 ACTIVITY THROUGH PHOSPHORYLATION%REACTOME DATABASE ID RELEASE 57%6804756 Regulation of TP53 Activity through Phosphorylation 17535 69263 69181 68776 12021 19718 66464 19891 209361 15257 68240 20833 99730 77976 319944 108099 24074 19079 108143 108097 12189 19094 17248 19082 270627 11920 12568 20878 231724 228980 237911 327762 21975 22059 19355 216185 19367 20877 13000 72151 106344 12566 100039026 17165 22427 68275 19356 12144 235559 15258 12569 21374 72119 60599 114741 13001 22190 667035 12427 108079 241113 26416 19360 23988 76367 235610 17246 226182 12795 81601 225182 27354 15574 50883 72504 21343 407786 20869 12649 26909 12428 105787 SIGNALING BY FGFR3 IN DISEASE%REACTOME DATABASE ID RELEASE 57%5655332 Signaling by FGFR3 in disease 14184 18708 18706 327826 18803 18176 20662 64654 14173 80903 14164 14388 14172 80857 14180 16653 15461 14175 PURINE SALVAGE%REACTOME DATABASE ID RELEASE 57%74217 Purine salvage 27369 13178 11717 109674 66355 229665 75894 11534 105446 11821 11486 15452 18950 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS%REACTOME DATABASE ID RELEASE 57%442755 Activation of NMDA receptor upon glutamate binding and postsynaptic events 12323 55984 13385 108058 53623 12322 19417 11514 12326 18039 20130 15461 18747 110651 14812 18749 109880 432530 14811 20111 14813 104111 12912 640703 100986 14814 12325 26413 20112 110157 18607 67071 11472 14810 14799 14802 19418 14800 SIGNALING BY RETINOIC ACID%REACTOME DATABASE ID RELEASE 57%5362517 Signaling by Retinoic Acid 12895 27402 218772 12894 19401 241452 19411 546726 28200 108841 13082 19378 11668 26876 232174 19682 242285 56847 11522 237320 20148 19015 12903 98711 216454 105014 17252 20182 12904 16592 235339 105349 20183 18604 27273 13382 20181 18597 228026 68263 236900 REGULATION OF GENE EXPRESSION IN LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS%REACTOME DATABASE ID RELEASE 57%210744 Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells 19664 15205 15379 11925 246086 21410 18128 CHOLESTEROL BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 57%191273 Cholesterol biosynthesis 13360 18194 73166 74754 20775 98386 14593 16987 110196 68603 110460 14137 319554 192156 100040592 15490 235293 66234 17855 13121 13595 68865 DEADENYLATION OF MRNA%REACTOME DATABASE ID RELEASE 57%429947 Deadenylation of mRNA 69125 231464 53621 218693 232791 72068 72587 103135 58184 78893 74108 234594 52846 13684 208643 192170 13682 104625 18983 228140 13681 18458 75705 SIGNALING BY FGFR3%REACTOME%R-HSA-5654741.2 Signaling by FGFR3 17346 12402 24064 56438 26395 67603 319520 235584 26403 16416 12223 54519 100042150 21894 11600 19060 19186 19188 327826 17169 194231 109905 14161 226525 57296 67151 215449 18710 19185 66998 53380 14172 17967 15461 17463 83409 69077 29875 12912 26417 26413 12323 108058 12322 18015 59029 19197 19417 19184 19179 22190 14425 20422 171463 14573 667035 19182 16590 240057 19181 64654 231474 14173 80903 14164 23997 66997 18039 218397 110135 14585 14178 80857 228769 14180 70247 67089 14586 14587 14175 21762 14177 23996 20416 11876 14165 26554 18596 109880 16399 54153 18708 15200 640703 18706 18673 12325 16818 16706 69601 83379 22371 73902 233046 114716 12981 19415 63953 14174 12982 19252 16653 12984 240672 13537 12988 67836 16186 13385 14588 211323 16184 11836 18188 20740 20739 13645 16185 16452 216869 109689 18176 72399 70686 114715 240168 14268 66413 211255 18183 14083 16451 19192 16453 26445 19166 18218 12576 14812 76089 26444 26446 14811 26443 14813 19414 80297 14814 12575 74769 16183 20742 18707 18709 20741 21687 20743 16367 13866 14810 16192 26396 14360 16191 216148 114713 14186 19418 22123 20662 19052 14170 19053 19262 73699 640524 16913 75590 19175 19177 51792 19713 19170 22330 99571 13874 103554 16912 54401 83961 56637 16188 19173 19172 21770 107971 26932 100986 226849 18611 23980 20418 26931 320484 225849 384783 12675 245684 67112 110157 19167 26441 19419 11472 19171 545987 13649 70727 18595 26442 26440 101809 18591 18750 19088 16334 76850 18753 18754 236511 19247 16337 75778 15370 18752 104110 229709 12519 12524 606496 244650 18573 12015 56717 22084 224129 77647 11513 11512 239528 11515 11514 12371 98432 117150 18803 56458 56484 213988 12326 11652 18717 12478 11651 15937 16440 78757 228775 12487 110355 18747 18574 16438 18749 217351 210044 18575 432530 233833 23797 104111 67605 18720 17246 56716 18719 214150 108083 19087 19085 18607 19084 14388 22324 19211 227743 18718 109270 17454 16439 58988 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING%REACTOME%R-HSA-2173788.1 Downregulation of TGF-beta receptor signaling 65112 20901 66313 56424 17131 170749 17872 17127 75788 19045 17126 68010 83814 22190 667035 103573 19046 56207 21803 19047 21813 21812 14479 INTEGRIN ALPHAIIB BETA3 SIGNALING%REACTOME DATABASE ID RELEASE 57%354192 Integrin alphaIIb beta3 signaling 16416 54519 12927 20963 21894 109905 14161 20662 223864 215449 14268 110135 12928 11651 14083 19395 56508 99571 20416 16399 22371 18607 19419 12988 19246 FGFR2B LIGAND BINDING AND ACTIVATION%REACTOME%R-HSA-190377.1 FGFR2b ligand binding and activation 67112 14173 14165 14164 14174 14178 14181 72514 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION)%REACTOME DATABASE ID RELEASE 57%70614 Amino acid synthesis and interconversion (transamination) 14661 209027 72560 27053 107272 18242 66194 70266 104816 14719 14645 11484 73748 69051 236539 216456 76282 14718 100678 14660 GENE SILENCING BY RNA%REACTOME DATABASE ID RELEASE 57%211000 Gene Silencing by RNA 218210 66679 18226 76850 67710 69912 17749 66420 236511 245841 227720 319181 54563 223921 71981 103468 70699 20021 232440 69241 72787 94244 269113 231042 234865 69736 19069 66715 382522 107939 13206 319176 170762 15519 59015 227699 624153 14000 69833 72322 320727 74068 625328 94223 18141 51788 192119 20022 15077 23992 69920 21357 445007 231329 108989 319149 19386 100043714 20020 83456 69482 71805 57746 15267 319183 98558 22099 53424 319182 239528 319178 319186 319190 213988 319168 319167 72634 74691 217351 233833 57749 214150 17864 330890 210510 319188 15270 83561 319169 19384 78303 TIE2 SIGNALING%REACTOME%R-HSA-210993.1 Tie2 Signaling 20416 19247 18708 11600 18706 14786 74769 11602 18176 20662 18709 21687 13449 16653 15461 50915 11601 ECM PROTEOGLYCANS%REACTOME%R-HSA-3000178.1 ECM proteoglycans 104099 16416 12839 13138 11603 14264 17967 19280 17022 666279 12845 15891 12950 17180 21960 17183 66695 20692 329278 13004 12111 13179 16420 21808 13003 12032 16772 16777 241226 21803 16404 81877 17182 13406 21809 18198 228357 12840 16774 22370 16399 16398 16773 12841 226519 16419 16411 16776 16775 16779 16412 18787 16410 21923 WNT LIGAND BIOGENESIS AND TRAFFICKING%REACTOME DATABASE ID RELEASE 57%3238698 WNT ligand biogenesis and trafficking 22415 22423 22418 53627 22416 216795 68151 22411 20890 22410 56433 22417 73130 22414 22408 93735 22421 22422 30930 22412 65114 54198 22409 22419 22413 22420 ACETYLATION%REACTOME DATABASE ID RELEASE 57%156582 Acetylation 17960 17961 SMAC BINDS TO IAPS%REACTOME DATABASE ID RELEASE 57%111463 SMAC binds to IAPs 12369 12367 11798 12371 66593 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES%REACTOME DATABASE ID RELEASE 57%380270 Recruitment of mitotic centrosome proteins and complexes 19088 76816 18817 56455 76478 71909 219072 214552 237222 20873 18536 104318 22145 73738 26370 74470 219103 17997 99100 74360 68121 18472 27373 12009 13589 54130 76707 230376 22628 66296 236266 78887 18005 15519 381644 22154 225745 12534 214444 28135 231123 13427 13424 83922 208518 75786 18541 103733 101565 78177 69654 22153 225659 227613 16328 53598 22142 68475 22627 51792 18747 103768 51885 100986 75296 74237 259279 12537 101706 233276 BILE ACID AND BILE SALT METABOLISM%REACTOME DATABASE ID RELEASE 57%194068 Bile acid and bile salt metabolism 16204 12012 26459 83702 13123 13116 20493 28250 28253 20494 76408 12642 19223 13122 17978 17117 104086 20186 170789 77337 26458 11657 105349 101502 208665 20181 15488 13124 56050 27413 93732 17977 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES%REACTOME%R-HSA-380320.1 Recruitment of NuMA to mitotic centrosomes 17997 74237 12534 103768 51885 259279 101706 103733 233276 VXPX CARGO-TARGETING TO CILIUM%REACTOME%R-HSA-5620916.1 VxPx cargo-targeting to cilium 53869 211446 20336 53413 215445 13196 107371 233649 102058 69940 105504 18764 107338 216363 66482 18763 11843 212541 12789 17274 FORMATION OF THE HIV-1 EARLY ELONGATION COMPLEX%REACTOME DATABASE ID RELEASE 57%167158 Formation of the HIV-1 Early Elongation Complex 67710 17749 66420 245841 24116 66467 20021 69241 20924 20922 14884 66671 23894 57314 27632 12572 17420 13871 13872 58202 209357 68092 69833 14885 433702 68705 20022 67655 69920 231329 98053 100043714 20020 INTEGRATION OF ENERGY METABOLISM%REACTOME%R-HSA-163685.1 Integration of energy metabolism 100705 12289 12297 68465 11450 72674 58805 56327 14706 14678 14696 14677 14526 20907 14527 14688 14708 14693 14709 14697 12290 12286 56808 233081 22318 19052 223864 17118 19053 73699 20614 21428 16500 51792 238276 56508 107566 268345 240444 238076 18639 14699 108079 66066 53420 14700 14701 21770 14695 14652 14704 14702 20910 14710 64337 20869 20927 18796 18750 55979 19088 18795 16334 104112 11740 104110 229709 433923 109905 108099 108097 14104 18797 29875 16514 11551 11553 12671 107476 224129 11513 11512 11515 11514 20526 16440 18747 14682 16438 14675 18749 12296 14676 210044 14672 12288 432530 104111 20525 19087 19085 21881 19084 21351 11739 16439 CHEMOKINE RECEPTORS BIND CHEMOKINES%REACTOME DATABASE ID RELEASE 57%380108 Chemokine receptors bind chemokines 23832 56066 20312 20315 20299 15945 12772 20302 13051 252837 12458 55985 20297 20304 16963 20293 57349 56744 54199 20303 20295 20306 20296 66102 20292 12769 20290 59289 12767 56838 227288 12765 330122 12774 12766 100038965 80901 100039973 12777 17329 20311 20300 12145 14825 12775 12776 20310 12778 12768 12771 12773 REGULATION OF TP53 EXPRESSION%REACTOME DATABASE ID RELEASE 57%6804754 Regulation of TP53 Expression 22059 12142 COHESIN LOADING ONTO CHROMATIN%REACTOME%R-HSA-2470946.1 Cohesin Loading onto Chromatin 24061 20842 71175 20843 13006 71521 74549 19357 100710 218914 NS1 MEDIATED EFFECTS ON HOST PATHWAYS%REACTOME DATABASE ID RELEASE 57%168276 NS1 Mediated Effects on Host Pathways 218210 66679 100039592 18226 69912 100038882 227720 54563 223921 103468 16211 70699 16648 16649 72787 269113 231042 234865 69736 19069 107939 16646 170762 59015 227699 54196 18141 54188 445007 19106 381686 108989 19386 69482 71805 SIGNALING BY HEDGEHOG%REACTOME%R-HSA-5358351.2 Signaling by Hedgehog 15245 66313 66573 57810 13363 75788 66753 20423 18453 16147 216869 109689 66413 237222 19192 26445 19166 26444 26446 26443 26965 14632 226861 74239 240888 117606 19206 104346 14634 319757 56438 18222 230500 68525 71742 110350 76857 14451 20747 22123 59056 21402 74126 16913 19175 19177 19170 16568 103554 16912 56637 93687 19173 19172 19167 26441 19171 26442 26440 73916 19088 213081 271639 81896 21821 106633 11491 73668 67661 103978 77583 19186 214240 19188 22158 104110 245866 70300 380614 269523 380718 57296 67151 19185 66998 53380 20338 17463 69077 12234 116891 216440 244585 74682 59029 224129 11513 19184 22190 11512 19179 20422 11515 667035 11514 19182 19181 23997 24069 66997 14633 16396 228769 214498 70247 67089 110355 18747 21762 23996 18749 26554 210044 432530 104111 19087 19085 73902 19084 IMMUNE SYSTEM%REACTOME%R-HSA-168256.3 Immune System 56455 14600 19116 12700 216233 54130 13427 13424 69654 70093 67615 235320 100041484 224826 66743 67921 19820 15001 53598 215061 67455 140499 208154 232539 94090 57751 78913 14998 66772 65257 230903 13684 17237 672511 30945 229445 13682 70928 101358 67345 15000 13681 15002 217217 13034 106759 104184 67731 142980 77113 225471 68431 231863 56532 70294 76375 59009 14794 18744 16924 212919 242785 320118 70392 78541 211007 142688 69299 72194 76454 67845 242521 67128 269514 22222 627648 207215 66799 22019 231670 19349 22193 328234 56736 12449 100763 50788 399566 76294 208372 117589 60533 68854 72323 211949 74132 59044 94091 235439 268470 140630 217342 209239 230654 19823 224170 218215 54484 233040 214931 79263 209200 69010 78889 50723 71393 56515 244421 67138 233902 74492 69706 226977 227738 56228 448987 18566 70348 218793 56464 83962 217194 329152 224619 207304 224023 280408 209462 69754 321006 50760 100039535 224938 228003 109161 68497 22201 81018 22195 22209 69116 330369 65255 65247 380928 22036 74646 226098 140629 75234 231672 243574 19155 433766 76608 117146 213311 30843 78910 142687 64291 28105 67490 65256 226541 231380 230904 80898 635668 68729 269529 71999 22213 71538 22214 22215 240396 98766 23807 207952 58194 209737 11772 11771 71770 238055 218203 12757 232910 11773 13033 19348 16571 14103 67300 12796 18125 66397 18173 16165 18126 209590 12978 20586 12985 69677 54448 16568 16570 16572 73804 74764 110033 229841 16593 16551 116849 75717 16198 19152 100039592 76527 16160 237310 16197 16161 12931 108664 16175 17082 16199 26406 16211 13019 16648 93672 20908 16649 16155 16156 16181 237313 16196 338374 16880 246779 68098 93871 15234 215274 12804 50498 12803 16177 213208 16163 16162 230828 16174 329244 18413 16182 50931 107527 109658 58181 16068 12986 56708 18414 54473 83430 218624 16178 16173 14255 14256 16168 16878 215257 242700 16159 100042555 16170 16169 81897 216238 170743 56424 78287 54123 170744 332579 26415 12362 72162 75669 225326 12363 16396 12366 19106 381686 74244 12526 19246 20811 66313 75788 668303 252903 12402 74947 20907 21356 17973 14991 246256 20619 17096 21355 57257 20430 56378 330319 17913 22320 14191 20909 83767 18127 242687 12631 240095 22325 21354 11350 15007 18807 22319 15519 381925 12505 330662 66713 53357 22030 74256 19353 14082 21937 21926 56371 12370 19766 21929 20016 26939 70408 67486 12909 78929 20018 67065 67005 218832 69870 70428 74414 18383 245527 85030 230979 21938 57916 13608 21936 21940 66156 17535 240028 16563 52206 16573 668450 22194 70620 216080 15204 16569 12500 67588 71819 21948 240873 171211 21935 326623 232943 22164 22163 13607 108012 11768 22631 52563 99152 11767 26934 69957 68999 68612 11765 11764 17222 16579 73470 17060 83490 15985 208650 12518 26377 11769 12143 17750 59008 228421 56317 107995 217232 16594 12702 16195 192170 72049 21947 53859 17000 12260 20437 667277 317677 76500 12944 19109 21934 22031 24099 21943 11797 16992 27279 50930 20866 18751 21944 11796 109305 16994 17002 269717 105855 14131 245880 140580 50884 108100 56443 68524 11461 12929 16885 329165 101314 140579 14129 104759 18805 234779 18806 15516 17886 17882 12502 76884 12928 22612 18479 71910 80987 17918 76709 17925 17909 215280 15162 11465 73178 22376 68089 74117 11308 14026 67771 11867 107746 12259 17195 14134 12262 16854 108723 239447 54483 319430 195046 16822 22210 620235 108086 668101 16362 12628 53323 16428 16803 30839 12772 230398 72512 20193 20201 15977 54131 66641 213980 55991 12010 30838 12042 12458 18521 30050 12630 20202 216150 16904 18018 18019 268857 16643 56620 21353 22040 17444 242960 56489 16363 50754 329547 50789 13038 19141 13430 18021 22072 22192 214763 103967 246082 18481 17084 13040 56743 56438 384309 16176 14375 56619 106052 18439 53791 50762 58203 224105 266632 26420 107607 11909 16476 17260 13712 434174 26414 13057 26395 26401 26398 26397 192656 17874 12491 67603 13058 100040260 223864 319520 17970 12229 17972 26419 17969 11820 17533 102626 246278 20203 17534 17258 24058 93765 12703 26940 56508 103583 21898 73914 23845 21899 11537 26399 270151 231130 12759 17087 73086 67245 93834 381809 13211 66589 14281 24088 26410 21897 235584 16179 69379 26403 71693 16416 22177 12223 110382 54519 12279 14828 230558 12504 100042150 446099 21894 12274 11600 12273 19060 109828 19186 15139 19188 17474 327826 26888 17169 100041766 194231 27007 109905 56644 14161 12266 226525 12267 57296 66105 67151 207521 215449 244332 18710 74153 19185 625018 66998 53380 19395 14172 12263 17967 629114 15461 17463 83409 69077 29875 11596 110651 12475 14827 20210 117149 12234 17164 72349 23900 20111 17086 12912 26400 26417 240518 26413 23939 20112 208643 257632 12317 22027 15979 22200 16421 12323 14469 22166 20343 108058 360213 56480 17470 12322 15975 66824 14130 18015 224762 56791 232790 59029 15978 72029 75345 19197 16364 100038882 629970 19417 15980 383619 16408 19184 13039 15894 19179 20821 78369 20422 80861 52855 171463 19200 246746 14573 74735 15006 328833 19182 667370 17221 100038830 16590 52668 22165 225825 240057 15958 12343 12520 19181 80890 56338 84544 231474 70110 217304 140497 80903 246727 19056 83382 23997 93679 19055 12525 66997 229644 17079 57781 18039 23960 13030 50928 218397 246728 667803 12501 110135 20847 13429 232801 14585 236573 240354 12480 14178 56631 14126 20612 228769 69550 225913 13052 70247 101700 52440 16401 67089 15900 14125 52685 14586 55932 12340 12483 14587 231655 20852 26904 21762 229898 268973 22329 23996 16391 54445 20416 80876 16409 11876 319236 217306 14165 19824 22370 26554 17318 14127 18596 19204 77674 109880 22670 23988 16399 229900 16414 54153 66854 18761 15200 56045 12043 640703 67525 12048 18673 55992 83433 12325 13653 14962 16818 58185 15896 16706 66141 11870 69601 94088 654464 83379 72935 16641 22371 19058 243958 73902 654465 54215 233046 58217 224840 114716 68628 19698 19294 12981 67955 30925 19415 170786 54698 63953 22596 100043861 14174 57444 69807 243864 12982 214158 75400 15898 19252 65972 19090 71326 16653 12265 654460 217303 12984 246700 240672 266620 13537 54139 654459 20400 12988 27056 21682 270152 67836 16186 13385 14588 211323 16184 11836 20963 18188 83814 20740 20739 13645 16185 16452 216869 109689 18176 72399 70686 114715 240168 14268 66413 211255 18183 14083 16451 19192 24105 16453 26445 19166 16331 16646 18218 15170 16194 14812 16193 76089 16332 26444 26446 14811 19374 26443 19373 14813 19414 54721 80297 14814 74769 16183 20742 18707 24014 18709 20741 21687 20743 16367 13866 14810 16192 26396 14360 16191 216148 114713 14186 74915 19418 22123 21871 66515 20662 14170 22063 19262 640524 100039636 16913 75590 19175 19177 19713 19170 22330 99571 13874 11966 103554 22346 16912 71745 54401 83961 16188 19173 19172 107971 100986 18611 11973 23980 20418 320484 11964 384783 110935 245684 67112 110157 19167 26441 19419 11472 19171 545987 13649 67923 70727 18595 26442 26440 19229 101809 18591 18750 19088 16334 76850 18753 18754 11491 236511 19247 66290 16337 75778 15370 18752 20404 104110 94212 229709 12519 12524 171095 257630 16172 11974 234836 57890 140806 242341 16171 50905 66892 13191 114143 11975 230861 11972 68775 112419 57743 23806 66237 17999 66212 13690 69162 19043 286940 606496 66144 15077 18037 338375 319149 66335 53421 76252 100043039 107568 19696 244650 18573 12015 12367 56717 22084 224129 77647 11513 11512 239528 27060 11515 16149 11514 73834 12371 140494 98432 117150 18803 56458 56484 213988 12326 11652 18717 12478 11651 15937 16440 78757 228775 12487 110355 18747 12550 18574 16438 18749 217351 210044 18575 432530 233833 23797 104111 67605 18720 17246 56716 18719 214150 108083 19087 19085 18607 16419 19084 14388 22324 19211 227743 18718 16412 109270 17454 16410 16439 58988 630146 54644 11840 228607 77371 216799 59288 77125 14960 22323 14968 22637 19260 23880 14969 19264 16797 19271 213575 217069 19089 234663 22428 71586 56469 12477 230073 19025 76580 99683 22190 108960 26409 13032 667035 93836 19128 64654 14173 14164 68652 66724 22034 66513 20848 80857 14180 20846 14175 14177 20851 20850 14389 18708 18706 19822 13426 333883 84585 20333 56417 12576 18854 80751 26965 71956 12575 27401 69583 50868 110350 58205 66663 170737 71865 12914 14897 268291 13200 59026 328572 636931 380711 110351 73998 20469 19052 19053 69608 73699 21402 51792 26416 56637 21770 26932 226849 12387 26931 225849 12675 19697 18033 18036 18035 16151 18034 16150 218210 20334 66679 18226 69912 17749 66420 245841 218811 227720 54563 223921 103468 70699 72787 29857 19094 269113 231042 234865 69736 19069 107939 170762 68097 24110 50873 59015 227699 69833 18141 13036 445007 108989 19386 100043714 69482 110379 71805 18412 12330 67526 11793 20439 67665 EXPORT OF VIRAL RIBONUCLEOPROTEINS FROM NUCLEUS%REACTOME DATABASE ID RELEASE 57%168274 Export of Viral Ribonucleoproteins from Nucleus 218210 66679 18226 69912 227720 54563 223921 103468 70699 72787 269113 231042 234865 69736 19069 107939 170762 193740 103573 59015 227699 18141 445007 108989 19386 19384 69482 71805 POTASSIUM TRANSPORT CHANNELS%REACTOME DATABASE ID RELEASE 57%1296067 Potassium transport channels 16513 16517 56379 METABOLISM OF INGESTED SEMET, SEC, MESEC INTO H2SE%REACTOME%R-HSA-2408508.2 Metabolism of ingested SeMet, Sec, MeSec into H2Se 11720 140483 14711 107869 50880 12411 269378 18113 TRANSCRIPTIONAL ACTIVATION OF CELL CYCLE INHIBITOR P21%REACTOME%R-HSA-69895.2 Transcriptional activation of cell cycle inhibitor p21 59092 22059 12575 29813 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6%REACTOME DATABASE ID RELEASE 57%69017 CDK-mediated phosphorylation and removal of Cdc6 59029 19184 19179 22190 20422 19186 19188 667035 19182 19181 57296 23997 67151 66997 66413 19185 66998 53380 16913 228769 19192 70247 19175 19177 67089 26445 17463 19166 19170 69077 21762 23996 103554 16912 26444 26446 19173 26443 19172 73902 19167 12566 26441 23834 19171 26442 26440 22123 ADENYLATE CYCLASE INHIBITORY PATHWAY%REACTOME%R-HSA-170670.1 Adenylate cyclase inhibitory pathway 210044 432530 224129 11513 11512 104111 11515 11514 104110 14678 14677 14679 242851 14680 NEPHRIN INTERACTIONS%REACTOME DATABASE ID RELEASE 57%373753 Nephrin interactions 17973 109711 73178 18708 67703 20740 18706 12488 243911 11474 74769 20742 18709 11472 50791 60595 17974 14360 12361 29875 INHIBITION OF HSL%REACTOME DATABASE ID RELEASE 57%164928 Inhibition of HSL 11652 18576 U12 DEPENDENT SPLICING%REACTOME DATABASE ID RELEASE 57%72165 U12 Dependent Splicing 110809 225027 67710 17749 66420 245841 67996 20021 20382 69241 66055 50996 20624 76167 22184 74351 66125 67332 20638 78372 100040177 68092 20641 67225 69833 433702 384091 68705 107686 20022 69920 68879 231329 98053 320632 100043714 666609 27756 20020 22608 67197 107701 67797 67178 81898 66585 319322 27366 101943 192159 72047 TRUNCATIONS OF AMER1 DESTABILIZE THE DESTRUCTION COMPLEX%REACTOME%R-HSA-5467348.2 Truncations of AMER1 destabilize the destruction complex 11789 56637 93687 72345 21770 26932 226849 12005 26931 225849 19052 19053 73699 51792 P75NTR RECRUITS SIGNALLING COMPLEXES%REACTOME DATABASE ID RELEASE 57%209543 p75NTR recruits signalling complexes 18049 18412 18759 16150 22034 22190 18053 667035 192656 17874 16179 INTERFERON SIGNALING%REACTOME DATABASE ID RELEASE 57%913531 Interferon Signaling 16362 16452 230398 15977 54131 12010 16451 12702 56417 16646 15170 14991 18854 16363 54721 240095 15007 24014 12505 192170 14960 14968 14969 13684 217069 16913 13682 93765 12703 13681 56469 230073 218210 66679 18226 100039592 18753 69912 76500 19247 227720 54563 22194 223921 103468 70699 16211 16648 72787 16649 74153 17967 269113 231042 234865 69736 19069 107939 66892 170762 230861 112419 23806 17999 24110 13690 19043 26417 286940 59015 227699 18141 208643 445007 108989 19386 69482 71805 12323 15979 108058 14469 12322 360213 15975 56791 54123 224762 15978 100038882 16364 15980 22190 15894 20821 667035 15006 74735 14129 667370 52668 18803 15958 80890 70110 246727 93679 229644 23960 667803 246728 20847 236573 56631 69550 101700 20846 15900 55932 231655 229898 22329 16391 80876 319236 19824 17318 19204 22670 23988 229900 66854 56045 67525 55992 12325 13653 58185 17750 66141 94088 57444 19106 214158 381686 65972 12265 54139 19246 27056 MUSCARINIC ACETYLCHOLINE RECEPTORS%REACTOME DATABASE ID RELEASE 57%390648 Muscarinic acetylcholine receptors 12671 12669 12672 243764 213788 DISEASES OF METABOLISM%REACTOME DATABASE ID RELEASE 57%5668914 Diseases of metabolism 100705 110821 72039 66904 109136 78038 22130 54219 15926 22190 109129 238505 67096 667035 13853 210009 52713 17200 93835 14603 21452 65969 14149 53412 13070 18563 20390 20389 18976 20388 20387 17850 68165 14148 27357 12982 107476 232493 12984 14936 INTERFERON ALPHA BETA SIGNALING%REACTOME%R-HSA-909733.1 Interferon alpha beta signaling 14469 15975 54123 16364 100038882 76500 19247 16362 15006 667370 52668 15958 230398 70110 246727 15977 23960 54131 246728 667803 20847 16913 16451 69550 12703 12702 15900 231655 56417 15170 16391 14991 80876 112419 56045 54721 24110 16363 240095 13653 58185 15007 66141 24014 57444 19246 54139 27056 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE%REACTOME%R-HSA-168176.1 Toll Like Receptor 5 (TLR5) Cascade 19094 11596 110651 20210 12234 17164 72349 26965 20111 12912 26400 26417 240518 26413 23939 20112 257632 53791 266632 26420 107607 11909 16476 17260 13712 434174 22190 26414 108960 26395 26409 26401 667035 26398 26397 192656 17874 67603 19052 100040260 19053 319520 73699 26419 68652 11820 21402 66724 102626 22034 20203 66513 17258 93765 51792 26940 103583 26416 21770 12675 19697 18033 26399 18036 18035 231130 16151 18034 73086 16150 67245 93834 13211 66589 14281 26410 235584 16179 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF)%REACTOME DATABASE ID RELEASE 57%1655829 Regulation of cholesterol biosynthesis by SREBP (SREBF) 100705 20334 56406 14732 18045 20775 218811 109151 16211 170439 68603 14104 77371 100040592 229003 20249 19013 19014 17764 17978 18046 99683 107476 20181 13121 18044 17977 56453 13360 12914 81004 110196 14137 69608 270669 192156 66397 20683 17855 21372 66993 73166 72999 14593 16987 59035 20788 319554 231070 235623 235293 19384 RIPK1-MEDIATED REGULATED NECROSIS%REACTOME DATABASE ID RELEASE 57%5213460 RIPK1-mediated regulated necrosis 22030 56532 14082 21933 14102 14103 11797 22035 12370 71609 19766 74568 11796 11798 VISUAL PHOTOTRANSDUCTION%REACTOME%R-HSA-2187338.1 Visual phototransduction 109791 18750 14734 68453 242864 103978 241452 11603 18107 14539 12057 19682 11806 11808 20148 14688 11813 98711 216454 238055 11807 17252 14735 69060 18587 225600 214111 18588 16956 77337 11814 105349 20215 12788 16835 665270 212541 11816 19659 63857 65107 79235 67861 107477 14272 243923 55938 20971 102294 15485 11304 20969 19662 77974 83702 19771 19660 70061 19892 20897 239393 17921 170752 14725 19661 235033 27400 71951 23888 14699 15530 18108 22139 16971 18761 640703 20970 245650 19674 15529 14919 56307 237178 14685 14733 24013 110606 75624 14913 73582 PKA-MEDIATED PHOSPHORYLATION OF KEY METABOLIC FACTORS%REACTOME DATABASE ID RELEASE 57%163358 PKA-mediated phosphorylation of key metabolic factors 18639 18749 58805 18747 PHENYLALANINE AND TYROSINE CATABOLISM%REACTOME%R-HSA-71182.2 Phenylalanine and tyrosine catabolism 14204 234724 70266 14874 15445 15233 18478 110391 13180 66514 14085 UPTAKE AND FUNCTION OF DIPHTHERIA TOXIN%REACTOME DATABASE ID RELEASE 57%5336415 Uptake and function of diphtheria toxin 15516 50493 13629 12527 15200 15519 ENOS ACTIVATION%REACTOME%R-HSA-203615.2 eNOS activation 12389 11651 51793 640703 18127 114886 68268 69219 18777 15519 PROCESSING OF INTRONLESS PRE-MRNAS%REACTOME DATABASE ID RELEASE 57%77595 Processing of Intronless Pre-mRNAs 98985 67337 228410 68219 51786 68092 54196 54188 54451 433702 108062 66899 18789 94230 269061 SIGNALING BY WNT IN CANCER%REACTOME%R-HSA-4791275.1 Signaling by WNT in cancer 14370 14368 14367 207742 53627 13016 19052 19053 13017 73699 22416 51792 16974 21951 11789 56637 93687 72345 21770 26932 226849 74493 12387 12005 26931 225849 234130 84035 21416 13380 73016 16973 56811 14366 VIRAL RNP COMPLEXES IN THE HOST CELL NUCLEUS%REACTOME%R-HSA-168330.1 Viral RNP Complexes in the Host Cell Nucleus 193740 AQUAPORIN-MEDIATED TRANSPORT%REACTOME DATABASE ID RELEASE 57%445717 Aquaporin-mediated transport 12000 53869 19088 224129 11513 11512 11826 11515 11514 104110 11833 14706 14696 14688 14708 14693 14709 18747 14697 14699 18749 66066 74998 14700 11831 210044 14701 11832 17339 432530 11830 11829 104111 14695 66333 11998 14704 14702 11827 14710 17919 64337 19087 19085 19084 64008 11828 208760 BUTYRATE RESPONSE FACTOR 1 (BRF1) BINDS AND DESTABILIZES MRNA%REACTOME DATABASE ID RELEASE 57%450385 Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA 50911 54401 12192 17164 75901 72662 72544 24127 66446 27998 69639 66583 66362 11651 109075 70640 227715 ATTENUATION PHASE%REACTOME DATABASE ID RELEASE 57%3371568 Attenuation phase 12914 68196 328572 193740 15481 81489 15482 15512 100043508 14228 15519 15499 15516 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE%REACTOME DATABASE ID RELEASE 57%77075 RNA Pol II CTD phosphorylation and interaction with CE 67897 67710 24018 17749 66420 245841 66467 20021 69241 20924 14884 66671 23894 12572 17420 13871 13872 209357 69833 14885 68705 20022 69920 231329 98053 100043714 20020 DERMATAN SULFATE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 57%2022923 Dermatan sulfate biosynthesis 319901 212898 121021 13003 338362 12032 13004 12111 29873 72136 13179 DCC MEDIATED ATTRACTIVE SIGNALING%REACTOME DATABASE ID RELEASE 57%418885 DCC mediated attractive signaling 17973 13176 330662 73178 319713 19353 226251 231148 14083 18208 14360 223435 GENERIC TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 57%212436 Generic Transcription Pathway 69263 19718 18538 19891 68240 20878 219103 13000 72151 106344 100039026 68275 11909 16476 216456 14660 19042 64930 18861 17350 17685 66096 54170 245670 68576 14281 20869 68441 26909 66508 52187 105787 170936 68428 72611 217166 244216 13197 18227 13163 234366 72306 268936 66105 83409 22678 20182 433759 93681 12450 71131 237775 58184 226830 80707 107986 22693 67821 233107 20183 69131 27274 239546 237758 70227 229542 22166 13001 67956 16590 268973 23988 231464 64058 56406 56222 68776 18667 66464 83814 26992 209361 228839 66467 20833 333654 99730 319944 24074 108143 270627 20924 20922 22704 69562 12393 14884 14776 228980 67338 27374 13866 11816 107951 21374 12454 114741 24116 21933 14102 52892 22260 12861 110323 20930 66379 54401 76367 23894 57314 27632 226182 13871 13872 58202 209357 14885 13716 72504 67655 21343 545987 67923 27224 72949 12455 21399 22062 21981 76850 236511 15370 16009 209456 68742 22061 74370 12368 56717 22084 239528 12362 213988 11652 12366 11651 78757 217351 233833 23797 17246 56716 214150 18148 18607 50493 19211 227743 109270 17454 18519 330463 66313 228829 56707 22654 219022 107932 30944 109151 210135 74400 434377 216848 77976 15510 80509 230162 193452 433586 69228 18983 23942 240064 22632 56314 22648 21420 244219 21419 319530 210104 11835 233060 17165 675812 12640 245595 22690 74120 110052 72556 53376 66214 19646 14751 60599 68036 78893 75613 94112 269870 18091 21388 12447 21802 228491 21372 22627 94093 103836 14219 13864 21408 12122 30942 17127 353187 15378 12142 59024 53325 12177 544922 233893 19664 327987 666581 407786 75747 449521 57745 69020 17535 59092 243906 12021 619310 67911 243372 100039786 245368 244556 216080 235682 22640 327963 240087 110109 319801 12189 19016 17248 12568 11920 19013 19015 19014 231724 237911 14463 55948 327762 21849 12448 21975 22059 235956 19355 68975 22631 70625 22629 234959 22628 18997 18996 70208 19367 264064 12534 12566 230784 171285 22427 381549 56771 19356 241764 12144 240068 29813 67370 235559 15258 75692 20185 20602 330301 22190 93836 667035 78783 12427 22025 22026 234594 52679 232854 72739 12227 69792 67235 21907 19352 71361 19364 19360 56187 235610 66813 17192 81601 59035 225182 27354 382985 15574 50883 74747 12532 252870 18477 97064 12649 22775 18787 12428 244713 11783 235028 101095 69181 209225 208836 434178 332937 106931 15257 69234 66262 20620 22337 21677 229003 22751 66494 210503 228140 23957 23989 12579 11799 69790 12576 12578 77519 64050 211586 80751 19651 18854 670717 22709 19650 12868 353310 15182 12572 12575 216185 75605 17420 13555 80902 21781 12905 28077 12662 243963 104625 242109 245688 170753 12569 17992 17710 243834 12914 17131 17709 218772 328572 19401 70207 22339 19411 20463 225655 17684 231430 72720 17708 70088 384763 19052 19053 12857 226896 73699 619331 13496 213011 20683 13559 12705 104394 100041785 272347 51792 17869 66142 66671 12858 77827 72416 22689 108079 53621 241113 66359 26416 232791 72068 66993 17128 17126 12795 26931 22601 216154 12053 22750 52846 233056 71063 72723 18131 18129 18128 269704 66272 18132 69802 72154 69125 192292 67710 26381 26380 17749 238690 66420 245841 17283 21815 333639 268417 20021 234725 69241 56525 12028 26379 108099 74570 57748 19079 108097 19094 72805 67279 19082 228876 22696 230899 103806 666311 77683 11545 19885 20482 69076 13983 225998 76390 20481 19883 52712 236193 17978 20877 74352 69833 15469 68705 20022 69920 78251 18741 231329 14088 98053 211651 20181 432769 100043714 68744 20020 22757 17977 231866 110147 72119 81004 57913 21678 21679 239652 21672 14534 195522 21676 20393 13982 17988 26896 51813 21418 22284 270118 22196 244349 232784 17865 192651 170740 13865 16477 21834 21833 72180 67381 26423 100041581 14381 72230 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS%REACTOME%R-HSA-2691232.1 Constitutive Signaling by NOTCH1 HD Domain Mutants 11487 225164 240055 11491 22190 76580 18011 667035 54485 13388 16450 16449 18128 ONCOGENE INDUCED SENESCENCE%REACTOME DATABASE ID RELEASE 57%2559585 Oncogene Induced Senescence 76850 236511 22190 667035 213988 23872 100043858 23871 12580 13875 12567 20683 12579 12578 217351 233833 22059 12571 13557 17246 26417 26413 13555 214150 21781 15901 242705 17454 SIGNALING BY EGFRVIII IN CANCER%REACTOME%R-HSA-5637812.1 Signaling by EGFRvIII in Cancer 20416 18708 18706 13645 12402 15519 18176 18803 12539 20662 14388 13649 16653 15461 FASL CD95L SIGNALING%REACTOME%R-HSA-75157.1 FasL CD95L signaling 14082 14102 14103 12370 DEFENSINS%REACTOME%R-HSA-1461973.1 Defensins 77674 12504 11870 12772 22072 654464 654465 246082 244332 75400 12458 24088 629114 654460 246700 266620 21897 654459 DEFECTIVE EXT2 CAUSES EXOSTOSES 2%REACTOME DATABASE ID RELEASE 57%3656237 Defective EXT2 causes exostoses 2 15530 14734 14735 15529 20971 103978 20969 14733 71951 11603 23888 20970 CELL REDOX HOMEOSTASIS%REACTOME%R-HSA-1222541.1 Cell redox homeostasis TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS%REACTOME%R-HSA-159234.1 Transport of Mature mRNAs Derived from Intronless Transcripts 218210 66679 18226 69912 227720 54563 223921 103468 70699 72787 51786 13684 53319 269113 231042 234865 69736 94230 19069 107939 170762 59015 227699 20492 68092 18141 54188 54451 433702 445007 66899 108989 19386 21681 69482 71805 CYCLIN B2 MEDIATED EVENTS%REACTOME%R-HSA-157881.1 Cyclin B2 mediated events 12531 12534 12532 12530 12442 ANDROGEN BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 57%193048 Androgen biosynthesis 56348 15492 78925 15497 12640 94224 16866 13074 15487 57357 18976 TRISTETRAPROLIN (TTP, ZFP36) BINDS AND DESTABILIZES MRNA%REACTOME DATABASE ID RELEASE 57%450513 Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA 50911 54401 17164 75901 72662 72544 24127 66446 27998 69639 22695 238799 66583 66362 109075 70640 227715 SEMA3A PAK DEPENDENT AXON REPULSION%REACTOME DATABASE ID RELEASE 57%399954 Sema3A PAK dependent Axon repulsion 18186 243743 18846 18845 19353 20346 16885 12631 15519 15516 18481 14360 18479 14159 18844 224105 TRNA PROCESSING IN THE NUCLEUS%REACTOME%R-HSA-6784531.3 tRNA processing in the nucleus 218210 68045 66679 70047 18226 102614 69912 68626 227720 54563 223921 103468 67106 70699 72787 66637 67724 28088 66161 269113 231042 234865 104721 69736 76265 19069 94230 66078 107939 170762 59015 227699 18141 54188 108062 208366 445007 108989 117109 19386 69482 71805 67676 98985 67053 381802 68215 227522 98404 54364 74097 73192 19384 REGULATION OF INSULIN SECRETION%REACTOME DATABASE ID RELEASE 57%422356 Regulation of insulin secretion 18750 18796 12289 19088 18795 16334 12297 11740 229709 433923 109905 56327 14706 14678 14696 14677 14526 20907 14688 14708 14693 18797 14709 29875 14697 16514 12290 11551 11553 12286 12671 56808 233081 22318 224129 11512 11514 223864 17118 20526 20614 16440 16500 238276 56508 268345 107566 18747 240444 238076 14682 16438 14699 14675 18749 12296 66066 53420 14700 14676 14701 14672 12288 20525 14695 14652 14704 14702 20910 14710 64337 19087 19085 19084 11739 20927 16439 NONHOMOLOGOUS END-JOINING (NHEJ)%REACTOME DATABASE ID RELEASE 57%5693571 Nonhomologous End-Joining (NHEJ) 17535 12021 319183 319181 56626 319583 319182 319178 55982 319186 319190 70620 227525 107823 15204 70681 240087 12189 11920 93765 382522 70238 210766 27223 19360 107976 319152 75570 68251 81601 20184 27354 56196 108138 59004 22596 51869 319188 104884 54125 15270 19090 14375 78303 M G1 TRANSITION%REACTOME%R-HSA-68874.1 M G1 Transition 70024 18973 19186 19188 19891 68240 57296 67151 27214 66413 19185 66998 53380 18392 19192 26428 18393 26445 17463 26429 19166 69077 26444 26446 26443 13557 13555 12544 59001 12545 12566 242705 66979 18974 68275 22123 59029 18969 19075 19184 22190 19179 20422 57441 667035 19182 19181 23997 66997 16913 228769 50793 70247 19175 67089 19177 19170 21762 23996 17215 17219 103554 17217 16912 56452 19173 66634 19172 67177 73902 19167 23834 26441 19171 17216 18968 26442 19076 26440 17220 17218 ACTIVATION OF RAC%REACTOME DATABASE ID RELEASE 57%428540 Activation of Rac 17973 20663 19353 70584 20662 241656 214230 18481 17974 18479 20563 14733 19876 224105 AMINO ACID CONJUGATION%REACTOME DATABASE ID RELEASE 57%156587 Amino Acid conjugation 233801 117147 272428 107146 233799 435528 REGULATION OF TNFR1 SIGNALING%REACTOME DATABASE ID RELEASE 57%5357905 Regulation of TNFR1 signaling 22030 74256 53376 229603 30941 22190 21937 21926 667035 22258 11797 12370 71609 19766 21929 76686 432940 11796 24105 52440 268749 22029 66552 73218 106025 12675 16151 16150 14694 11798 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1%REACTOME DATABASE ID RELEASE 57%349425 Autodegradation of the E3 ubiquitin ligase COP1 19186 19188 57296 67151 66413 26374 19185 11920 66998 53380 19192 17463 26445 19166 69077 26444 26446 26443 22059 22123 59029 19184 22190 19179 20422 667035 19182 19181 23997 66997 16913 228769 19175 70247 67089 19177 19170 21762 23996 103554 16912 19173 19172 73902 19167 26441 19171 26442 26440 NEGATIVE REGULATION OF ACTIVITY OF TFAP2 (AP-2) FAMILY TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 57%8866904 Negative regulation of activity of TFAP2 (AP-2) family transcription factors 21418 226896 22196 233107 332937 106931 21420 80707 21419 SIGNALLING TO P38 VIA RIT AND RIN%REACTOME%R-HSA-187706.1 Signalling to p38 via RIT and RIN 56438 26395 67603 319520 235584 26403 16416 12223 54519 100042150 21894 11600 19060 19186 19188 327826 17169 194231 109905 14161 226525 57296 67151 215449 19185 66998 53380 14172 17967 15461 17463 83409 69077 29875 26417 26413 12323 108058 12322 18015 59029 19197 19417 19184 19179 22190 20422 171463 14573 667035 19182 16590 240057 19181 231474 64654 80903 14173 23997 14164 66997 18039 218397 110135 14585 14178 80857 228769 14180 70247 67089 14586 14587 14175 21762 14177 23996 20416 11876 14165 26554 18596 109880 16399 54153 15200 640703 18673 12325 16706 69601 83379 22371 73902 233046 114716 12981 19415 63953 14174 12982 19252 16653 12984 240672 13537 12988 67836 16186 13385 14588 211323 16184 11836 18188 20740 20739 13645 16185 16452 216869 109689 18176 18049 72399 70686 18211 114715 240168 14268 66413 211255 18183 14083 16451 19192 16453 26445 19166 18218 14812 76089 26444 26446 14811 26443 14813 19414 80297 14814 16183 20742 20741 21687 20743 16367 13866 14810 16192 26396 14360 16191 216148 114713 14186 19418 22123 20662 19052 14170 19053 19262 73699 640524 16913 75590 19175 19177 51792 19713 19170 22330 99571 13874 103554 16912 54401 83961 16188 19173 19172 21770 26932 107971 226849 100986 18611 23980 26931 20418 225849 320484 384783 245684 67112 110157 19167 26441 19419 11472 19171 545987 13649 70727 18595 26442 26440 101809 18591 19769 19762 REGULATION OF TP53 DEGRADATION%REACTOME DATABASE ID RELEASE 57%6804757 Regulation of TP53 Degradation 53376 56717 22190 667035 13163 12427 19052 19053 73699 11652 17248 20393 11920 11651 78757 51792 67338 12578 80751 22059 23797 12450 17246 26931 56716 18607 50883 12534 12566 252870 227743 109270 12428 P53-DEPENDENT G1 DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 57%69563 p53-Dependent G1 DNA Damage Response 59092 19186 19188 57296 67151 66413 17248 26374 19185 11920 66998 53380 19192 26445 17463 19166 69077 12576 26444 12448 26446 22059 26443 12575 12566 29813 22123 59029 19184 19179 22190 20422 667035 19182 12427 19181 23997 66997 16913 12447 228769 70247 19175 67089 19177 19170 21762 23996 103554 16912 19173 19172 17246 73902 50883 19167 26441 19171 26442 26440 12428 MITOTIC SPINDLE CHECKPOINT%REACTOME%R-HSA-69618.1 Mitotic Spindle Checkpoint 66156 17120 52206 668450 12236 12237 22194 52563 56150 59008 99152 56317 75430 216080 107995 69957 217232 52717 68999 68612 17222 HORMONE LIGAND-BINDING RECEPTORS%REACTOME%R-HSA-375281.1 Hormone ligand-binding receptors 14308 14714 22095 16867 14715 12640 14309 16866 22094 COPI-MEDIATED ANTEROGRADE TRANSPORT%REACTOME DATABASE ID RELEASE 57%6807878 COPI-mediated anterograde transport 16334 100042773 11842 67542 20740 233824 20739 333883 54161 66251 11840 56455 56395 77038 19324 59288 105785 56447 13191 68097 18195 53334 54160 50797 80297 12068 56041 56389 20742 11844 20741 66111 107338 20743 70349 13427 12847 13424 56418 110350 74498 56358 69654 224139 99412 76308 228998 56494 53598 213575 66913 108123 108124 640524 213827 97484 11843 11733 76332 11735 67665 234663 22428 59042 67511 102339 14275 54399 100042343 338337 13426 16834 68137 17957 PROTON-COUPLED MONOCARBOXYLATE TRANSPORT%REACTOME%R-HSA-433692.2 Proton-coupled monocarboxylate transport 12215 13723 80879 57274 20501 20503 FRS-MEDIATED FGFR2 SIGNALING%REACTOME DATABASE ID RELEASE 57%5654700 FRS-mediated FGFR2 signaling 56438 26395 67603 319520 235584 26403 16416 12223 54519 100042150 21894 11600 19060 19186 19188 327826 17169 194231 109905 14161 226525 57296 67151 215449 19185 66998 53380 14172 17967 15461 17463 83409 69077 29875 26417 26413 12323 108058 12322 18015 59029 19197 19417 19184 19179 22190 20422 171463 14573 667035 19182 16590 240057 19181 231474 64654 80903 14173 23997 14164 66997 18039 218397 110135 14585 14178 80857 228769 14180 70247 67089 14586 14587 14175 21762 14177 23996 20416 11876 14165 26554 18596 109880 16399 54153 15200 640703 18673 12325 16706 69601 83379 22371 73902 233046 114716 12981 19415 63953 14174 12982 19252 16653 12984 240672 13537 12988 67836 16186 13385 14588 211323 16184 11836 18188 20740 20739 13645 16185 16452 216869 109689 18176 72399 70686 114715 240168 14268 66413 211255 18183 14083 16451 19192 16453 26445 19166 18218 14812 76089 26444 26446 14811 26443 14813 19414 80297 14814 16183 20742 20741 21687 20743 16367 13866 14810 16192 26396 14360 16191 216148 114713 14186 19418 22123 20662 19052 14170 19053 19262 73699 640524 16913 75590 19175 19177 51792 19713 19170 22330 99571 13874 103554 16912 54401 83961 16188 19173 19172 21770 26932 107971 226849 100986 18611 23980 26931 20418 225849 320484 384783 245684 67112 110157 19167 26441 19419 11472 19171 545987 13649 70727 18595 26442 26440 101809 18591 19247 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%R-HSA-1368108.2 BMAL1:CLOCK,NPAS2 activates circadian gene expression 18627 79362 12914 56406 20893 18626 13170 20185 217166 328572 382056 15251 11865 109151 81004 59027 19017 18143 19013 229003 21372 19014 15183 14815 268903 66993 12753 12912 11998 19883 59035 17978 14068 20181 17691 12457 12952 18787 272322 17977 12953 GOLGI-TO-ER RETROGRADE TRANSPORT%REACTOME DATABASE ID RELEASE 57%8856688 Golgi-to-ER retrograde transport 16581 16554 209737 100042773 11842 16565 16564 26951 668303 20932 11840 67023 74947 56455 224630 12121 59288 20333 70218 18472 270192 11844 107338 53357 70349 13427 13424 12847 110350 19348 16561 18476 56358 69654 228998 16571 53598 213575 108123 108124 213827 11843 16568 16570 16572 73804 234663 74764 71116 22428 67511 110033 286942 76895 229841 68137 16593 16551 16563 16573 54161 66251 72772 16569 77038 19324 16562 71819 28169 240641 105785 232943 56447 13191 16552 68097 18195 18783 54160 50797 26934 66111 76308 16560 16579 108148 14423 19330 226407 66913 269152 19346 18475 75050 73470 67665 228421 59042 100042343 319991 16558 13426 16594 17957 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE%REACTOME%R-HSA-532668.2 N-glycan trimming in the ER and Calnexin Calreticulin cycle 67819 22190 19179 667035 269523 75841 12330 217364 74126 23802 66435 108687 19089 192193 20338 22644 66597 227619 66967 59007 193670 54197 14827 223455 116891 320011 225896 216440 19359 57377 12317 109154 14376 MEIOTIC SYNAPSIS%REACTOME%R-HSA-1221632.1 Meiotic synapsis 319181 232440 12189 94244 74075 77053 382522 319176 50878 71846 64009 20962 319565 20957 320558 66654 13006 15512 223697 19357 56739 140557 75459 497652 21749 624153 28113 101185 20842 51788 57321 15267 319183 319182 21750 319178 319186 319190 16906 319168 319167 24061 22196 20843 319152 319188 15270 319169 78303 EPHRIN SIGNALING%REACTOME%R-HSA-3928664.1 Ephrin signaling 13848 270190 13845 13641 13844 19353 13846 54126 13643 13642 216963 18481 17974 53378 14360 18479 224105 PROLINE CATABOLISM%REACTOME%R-HSA-70688.1 Proline catabolism 19125 212647 POLYMERASE SWITCHING%REACTOME DATABASE ID RELEASE 57%69091 Polymerase switching 19687 69263 67967 19718 18969 19075 18972 18538 69745 18971 72151 106344 18968 19076 MRNA DECAY BY 3' TO 5' EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 57%429958 mRNA decay by 3' to 5' exoribonuclease 72544 69305 66446 50911 27998 69639 66362 66583 109075 68106 72662 227715 G1 S-SPECIFIC TRANSCRIPTION%REACTOME DATABASE ID RELEASE 57%69205 G1 S-Specific Transcription 57813 67177 67141 20135 22171 18538 13361 12427 13555 21781 12544 12534 23834 12530 12447 18392 18968 INHIBITION OF IFN-BETA%REACTOME DATABASE ID RELEASE 57%168888 Inhibition of IFN-beta INTRAFLAGELLAR TRANSPORT%REACTOME DATABASE ID RELEASE 57%5620924 Intraflagellar transport 73916 213081 81896 21821 66061 106633 75465 73668 67068 67661 16579 76779 76411 245866 213575 100041639 109181 78802 56455 72421 16569 12589 238799 72938 74019 68259 67694 264134 16568 67286 16570 68097 71820 217935 76568 16559 67042 74682 110350 67344 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%R-HSA-1296041.1 Activation of G protein gated Potassium channels 14699 14700 16524 14701 16515 16522 16513 14695 16520 16517 14704 242425 14702 14710 16519 16518 16521 14706 16516 54393 14688 14708 14693 14709 DOWNSTREAM SIGNALING OF ACTIVATED FGFR4%REACTOME DATABASE ID RELEASE 57%5654716 Downstream signaling of activated FGFR4 56438 26395 67603 319520 235584 26403 16416 12223 54519 100042150 21894 11600 19060 19186 19188 327826 17169 194231 109905 14161 226525 57296 67151 215449 18710 19185 66998 53380 14172 17967 15461 17463 83409 69077 29875 12912 26417 26413 12323 108058 12322 18015 59029 19197 19417 19184 19179 22190 20422 171463 14573 667035 19182 16590 240057 19181 231474 64654 80903 14173 23997 14164 66997 18039 218397 110135 14585 14178 80857 228769 14180 70247 67089 14586 14587 14175 21762 14177 23996 20416 11876 14165 26554 18596 109880 16399 18708 54153 15200 640703 18706 18673 12325 16818 16706 69601 83379 22371 73902 233046 114716 12981 19415 63953 14174 12982 19252 16653 12984 240672 13537 12988 67836 16186 13385 14588 211323 16184 11836 18188 20740 20739 13645 16185 16452 216869 109689 18176 72399 70686 114715 240168 14268 66413 211255 18183 14083 16451 19192 16453 26445 19166 18218 12576 14812 76089 26444 26446 14811 26443 14813 19414 80297 14814 12575 74769 16183 20742 18707 18709 20741 21687 20743 16367 13866 14810 16192 26396 14360 16191 216148 114713 14186 19418 22123 20662 19052 14170 19053 19262 73699 640524 16913 75590 19175 19177 51792 19713 19170 22330 99571 13874 103554 16912 54401 83961 56637 16188 19173 19172 21770 107971 26932 100986 226849 18611 23980 20418 26931 320484 225849 384783 12675 245684 67112 110157 19167 26441 19419 11472 19171 545987 13649 70727 18595 26442 26440 101809 18591 18750 19088 16334 76850 18753 18754 236511 19247 16337 75778 15370 18752 104110 229709 12519 12524 606496 244650 18573 12015 56717 22084 224129 77647 11513 11512 239528 11515 11514 12371 98432 117150 18803 56458 56484 213988 12326 11652 18717 12478 11651 15937 16440 78757 228775 12487 110355 18747 18574 16438 18749 217351 210044 18575 432530 233833 23797 104111 67605 18720 17246 56716 18719 214150 108083 19087 19085 18607 19084 14388 22324 19211 227743 18718 109270 17454 16439 58988 FERTILIZATION%REACTOME%R-HSA-1187000.1 Fertilization 329954 56622 106757 22788 22787 71564 71078 12527 76856 73456 14595 75510 16532 22786 271036 320225 12659 212670 74096 11434 11495 74468 225865 COLLAGEN DEGRADATION%REACTOME%R-HSA-1442490.2 Collagen degradation 12818 140709 11487 12816 18550 30800 12839 17385 11491 237759 17390 77018 83995 12822 17392 12823 11502 12817 17384 17393 17394 13030 17395 12840 17381 17386 58223 13038 17387 12841 71753 72947 12821 12819 107581 13033 17388 50701 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX%REACTOME DATABASE ID RELEASE 57%937042 IRAK2 mediated activation of TAK1 complex 68652 66724 22034 66513 22190 108960 26409 667035 XBP1(S) ACTIVATES CHAPERONE GENES%REACTOME DATABASE ID RELEASE 57%381038 XBP1(S) activates chaperone genes 21894 381801 28106 56495 67398 140740 71853 11370 192193 105785 320209 14583 13191 12751 11972 57743 231997 66212 69162 71765 68090 72599 22642 28146 606496 100037258 11518 74322 16905 15191 69276 54616 53421 100043039 22393 27362 67838 52808 20818 228998 56494 50907 12282 52639 66515 107513 74126 20416 225849 EPHB-MEDIATED FORWARD SIGNALING%REACTOME DATABASE ID RELEASE 57%3928662 EPHB-mediated forward signaling 19877 19353 56443 11848 11461 16885 19878 545156 218397 14083 22612 18479 15461 76709 16443 13848 14812 270190 13845 17096 11465 13641 73178 13844 68089 56378 74117 13846 67771 11867 12631 13643 13642 16886 66713 15529 14810 14360 21844 110596 DEFECTIVE GALNT12 CAUSES COLORECTAL CANCER 1 (CRCS1)%REACTOME%R-HSA-5083636.1 Defective GALNT12 causes colorectal cancer 1 (CRCS1) 17829 224116 269328 100039649 353328 73732 17063 140474 PROCESSING OF CAPPED INTRONLESS PRE-MRNA%REACTOME%R-HSA-75067.1 Processing of Capped Intronless Pre-mRNA 98985 67337 228410 67332 68219 20638 51786 20492 68092 116748 54196 384091 433702 54451 54188 108062 66899 243963 18789 666609 72290 94230 269061 EICOSANOID LIGAND-BINDING RECEPTORS%REACTOME%R-HSA-391903.1 Eicosanoid ligand-binding receptors 21390 19214 58861 57260 19216 19218 14764 19220 19219 19217 16995 19222 70086 574402 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION%REACTOME DATABASE ID RELEASE 57%400508 Incretin synthesis, secretion, and inactivation 14463 14695 12591 225642 16392 64337 56529 69019 13482 14607 66286 236781 107221 14526 18508 242851 21416 18548 16846 233081 66624 76687 LECTIN PATHWAY OF COMPLEMENT ACTIVATION%REACTOME%R-HSA-166662.2 Lectin pathway of complement activation 17195 14134 NEF MEDIATED CD4 DOWN-REGULATION%REACTOME%R-HSA-167590.1 Nef Mediated CD4 Down-regulation 11771 71770 12504 108664 11772 232910 16818 11773 11840 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION%REACTOME DATABASE ID RELEASE 57%983168 Antigen processing: Ubiquitination & Proteasome degradation 66313 75788 22210 53323 30839 213980 30838 30050 216150 242960 50754 50789 22192 56438 106052 50762 70093 67615 235320 100041484 224826 66743 67921 19820 215061 67455 140499 56371 232539 94090 57751 78913 66772 65257 230903 17237 672511 30945 70928 93765 101358 12703 67345 103583 217217 104184 67731 77113 68431 231863 70294 76375 59009 14794 18744 16924 212919 242785 66589 320118 66156 70392 78541 211007 240028 142688 69299 52206 72194 668450 76454 67845 242521 22194 67128 19186 269514 19188 22222 70620 627648 207215 100041766 216080 66799 22019 15204 231670 57296 22193 67151 66105 328234 56736 12449 19185 74153 100763 66998 67588 50788 53380 399566 76294 208372 117589 17463 68854 69077 72323 211949 74132 59044 94091 235439 12234 268470 140630 217342 209239 230654 76580 19823 224170 52563 218215 99152 54484 233040 214931 79263 209200 69010 78889 71393 56515 244421 69957 67138 233902 74492 68999 69706 68612 227738 56228 448987 17222 22200 70348 218793 59029 83962 56791 217194 329152 19184 224619 19179 22190 207304 20422 224023 20821 667035 93836 209462 19182 69754 321006 50760 19181 100039535 224938 228003 23997 109161 66997 68497 22201 81018 22195 22209 69116 228769 330369 70247 65255 67089 65247 380928 22036 21762 74646 23996 226098 140629 75234 231672 26554 243574 19155 433766 76608 208650 117146 213311 30843 78910 142687 59008 28105 67490 56317 65256 226541 231380 73902 19822 230904 635668 68628 107995 68729 269529 71999 217232 22213 69807 71538 22214 22215 240396 98766 23807 207952 83814 66413 211255 19192 24105 12702 26445 19166 84585 26444 26446 80751 26443 26965 218203 27401 50868 22123 66663 170737 71865 14897 268291 59026 636931 73998 66515 21402 16913 19175 19177 19170 103554 22346 16912 71745 19173 19172 19167 26441 19171 67923 26442 26440 75717 20437 68098 17999 50873 107568 56424 16396 20439 74244 SEMA4D IN SEMAPHORIN SIGNALING%REACTOME%R-HSA-400685.2 Sema4D in semaphorin signaling 19877 232906 19353 11848 16885 19878 17886 56212 20130 19354 11852 213498 11853 71960 16886 67938 17880 13866 235611 17295 69632 20354 223881 77579 67268 17904 NEF MEDIATED CD8 DOWN-REGULATION%REACTOME%R-HSA-182218.1 Nef Mediated CD8 Down-regulation 11771 71770 108664 11772 232910 12526 11773 ACYL CHAIN REMODELING OF CL%REACTOME DATABASE ID RELEASE 57%1482798 Acyl chain remodeling of CL 225010 53357 18783 231086 66826 97212 TRUNCATED APC MUTANTS DESTABILIZE THE DESTRUCTION COMPLEX%REACTOME DATABASE ID RELEASE 57%4839744 truncated APC mutants destabilize the destruction complex 11789 56637 93687 72345 21770 26932 226849 12005 26931 225849 19052 19053 73699 51792 CAM-PDE 1 ACTIVATION%REACTOME%R-HSA-111957.1 Cam-PDE 1 activation 18573 18575 640703 18574 TERMINATION OF O-GLYCAN BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 57%977068 Termination of O-glycan biosynthesis 269328 100039649 73732 140474 17829 224116 353328 20442 17063 20448 20443 20447 20446 20440 20444 RSK ACTIVATION%REACTOME DATABASE ID RELEASE 57%444257 RSK activation 110651 18607 67071 20111 26413 20112 PROLONGED ERK ACTIVATION EVENTS%REACTOME DATABASE ID RELEASE 57%169893 Prolonged ERK activation events 56438 26395 67603 319520 77480 235584 26403 16416 12223 54519 100042150 21894 11600 19060 19186 19188 327826 17169 194231 109905 14161 226525 57296 67151 215449 19185 66998 53380 14172 17967 15461 17463 83409 69077 29875 26417 26413 12323 108058 12322 18015 59029 19197 19417 19184 19179 22190 20422 171463 14573 667035 19182 16590 240057 19181 231474 64654 80903 14173 23997 14164 66997 18039 218397 110135 14585 14178 80857 228769 14180 70247 67089 14586 14587 14175 21762 14177 23996 20416 11876 14165 26554 18596 109880 16399 54153 15200 640703 18673 12325 16706 69601 83379 22371 73902 233046 114716 12981 19415 63953 14174 12982 19252 16653 12984 240672 13537 12988 67836 16186 13385 14588 211323 16184 11836 18188 20740 20739 13645 16185 16452 216869 109689 18176 18049 72399 70686 18211 114715 240168 14268 66413 211255 18183 14083 16451 19192 16453 26445 19166 18218 14812 76089 26444 26446 14811 26443 14813 19414 80297 14814 16183 20742 20741 21687 20743 16367 13866 14810 16192 26396 14360 16191 216148 114713 14186 19418 22123 20662 19052 14170 19053 19262 73699 640524 16913 75590 19175 19177 51792 19713 19170 22330 99571 13874 103554 16912 54401 83961 16188 19173 19172 21770 26932 107971 226849 100986 18611 23980 26931 20418 225849 320484 384783 245684 67112 110157 19167 26441 19419 11472 19171 545987 13649 70727 18595 26442 26440 101809 18591 12929 18803 12928 107746 REGULATION BY TREX1%REACTOME%R-HSA-3248023.1 Regulation by TREX1 22040 SIGNALLING TO STAT3%REACTOME%R-HSA-198745.1 Signalling to STAT3 18049 18211 20848 REMOVAL OF THE FLAP INTERMEDIATE%REACTOME DATABASE ID RELEASE 57%69166 Removal of the Flap Intermediate 327762 67967 18969 14156 19075 18972 18538 19891 69745 68240 18971 68275 18968 19076 TP53 REGULATES TRANSCRIPTION OF ADDITIONAL CELL CYCLE GENES WHOSE EXACT ROLE IN THE P53 PATHWAY REMAIN UNCERTAIN%REACTOME%R-HSA-6804115.1 TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain 69125 231464 53621 232791 72068 66214 22059 12795 58184 78893 20620 18148 234594 52846 12532 12227 104625 18983 228140 219103 STAT6-MEDIATED INDUCTION OF CHEMOKINES%REACTOME%R-HSA-3249367.1 STAT6-mediated induction of chemokines 72512 56480 20852 PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR%REACTOME DATABASE ID RELEASE 57%392851 Prostacyclin signalling through prostacyclin receptor 14699 66066 14700 14701 14695 14704 14702 14710 64337 14706 14696 14688 14708 14693 14709 19222 14697 HATS ACETYLATE HISTONES%REACTOME%R-HSA-3214847.1 HATs acetylate histones 13486 18519 72195 217031 77853 228829 74026 621893 217127 66464 77766 67773 319181 230233 75565 18505 216825 228714 382207 76901 66233 66262 268936 269424 108155 76719 319189 71777 140858 208146 108143 226976 21427 54351 69612 58523 73247 223527 74195 56790 78656 107435 382522 27878 101206 13831 319176 75560 269003 28019 109115 72341 319173 64050 216185 246103 17978 56456 15077 100683 319149 245688 15161 17977 11909 12914 15267 319183 328572 11461 56505 319182 319178 319186 319190 78783 70088 20174 14534 319163 319168 319162 319167 244349 12753 81601 319188 225895 56397 108946 217588 319169 78303 17692 21761 102162 SIGNAL REGULATORY PROTEIN (SIRP) FAMILY INTERACTIONS%REACTOME DATABASE ID RELEASE 57%391160 Signal regulatory protein (SIRP) family interactions 15170 54353 22177 19261 19247 14083 16423 668101 23880 19229 DISEASES ASSOCIATED WITH GLYCOSAMINOGLYCAN METABOLISM%REACTOME DATABASE ID RELEASE 57%3560782 Diseases associated with glycosaminoglycan metabolism 14734 13003 12032 103978 20971 20969 11603 14264 18295 71951 27047 116847 16545 23888 17022 15530 14735 20970 121021 15529 13004 12111 29873 14733 13179 DAG AND IP3 SIGNALING%REACTOME%R-HSA-1489509.2 DAG and IP3 signaling 18750 19088 18573 18753 224129 18754 11513 11512 11515 11514 18752 104110 229709 18803 12326 16440 110355 18747 18574 16438 18749 210044 18575 432530 104111 12912 640703 19087 19085 19084 16439 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE%REACTOME%R-HSA-167160.1 RNA Pol II CTD phosphorylation and interaction with CE 67897 67710 24018 17749 66420 245841 66467 20021 69241 20924 14884 66671 23894 12572 17420 13871 13872 209357 69833 14885 68705 20022 69920 231329 98053 100043714 20020 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES%REACTOME DATABASE ID RELEASE 57%425397 Transport of vitamins, nucleosides, and related molecules 114304 11416 72621 330064 108115 70484 24060 11815 77701 26569 26457 225579 28250 77704 28253 73836 22232 228368 71279 58246 24059 63959 227394 269346 13340 11998 434203 108652 229782 101488 58807 11657 243328 242585 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE%REACTOME DATABASE ID RELEASE 57%416572 Sema4D induced cell migration and growth-cone collapse 19877 11853 19353 11848 16885 71960 19878 16886 67938 17886 17880 56212 13866 235611 69632 20354 223881 19354 77579 67268 11852 17904 213498 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM%REACTOME%R-HSA-196741.2 Cobalamin (Cbl, vitamin B12) transport and metabolism 17850 68421 17250 109136 54219 109129 238505 67096 210009 22072 14603 93835 21452 65969 77697 66473 76701 19300 RNA POLYMERASE II TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 57%73856 RNA Polymerase II Transcription Termination 193116 107829 110809 225027 60365 331401 66511 68278 67337 228410 68219 19826 67996 73666 20382 53817 51786 71713 70579 116748 66231 69823 233073 73826 69207 108014 386612 72290 17149 94230 100040029 192160 625193 67332 20638 225160 20492 68092 66441 54196 54188 433702 54451 384091 108062 64340 192170 66899 622469 51796 243963 21681 18789 666609 20383 68134 269061 98985 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING%REACTOME%R-HSA-936440.1 Negative regulators of RIG-I MDA5 signaling 74256 56480 56791 100038882 22190 108086 54644 22031 667035 53323 100041766 228607 216080 21929 66105 217069 54131 16396 74153 67526 18521 52440 11793 23988 56489 71956 71586 270151 230073 ABACAVIR METABOLISM%REACTOME DATABASE ID RELEASE 57%2161541 Abacavir metabolism 76952 14923 18534 75894 REGULATION OF TP53 ACTIVITY%REACTOME DATABASE ID RELEASE 57%5633007 Regulation of TP53 Activity 228829 69263 69181 68776 66464 19718 219022 107932 26992 209361 19891 68240 15257 20833 333654 216848 99730 66262 77976 319944 24074 108143 270627 20878 23942 228980 67338 12578 18854 80751 15182 216185 72151 13000 27374 106344 100039026 17165 68275 245688 12569 53376 21374 19646 328572 60599 114741 70088 19052 19053 73699 51792 108079 241113 26416 76367 12795 12142 226182 26931 53325 72504 21343 20869 407786 26909 105787 22062 21981 17535 12021 13163 234366 268936 108099 57748 19079 108097 12189 19094 17248 19082 12568 11920 231724 209456 237911 22061 77683 327762 21975 433759 22059 19355 12450 18997 226830 18996 19367 20877 12534 12566 22427 19356 241764 12144 29813 235559 15258 229542 56717 110147 72119 13001 22190 67956 667035 78783 12427 11652 20393 11651 78757 244349 23988 19360 23797 235610 17246 56716 17192 81601 225182 27354 15574 50883 18607 252870 227743 12649 109270 12428 G1 S DNA DAMAGE CHECKPOINTS%REACTOME%R-HSA-69615.1 G1 S DNA Damage Checkpoints 59092 19186 19188 57296 67151 66413 17248 26374 19185 11920 66998 53380 19192 26445 17463 19166 69077 12576 26444 12448 26446 22059 26443 12575 12566 29813 22123 59029 19184 19179 22190 20422 667035 19182 12427 19181 23997 66997 16913 12447 228769 70247 19175 67089 19177 19170 21762 23996 103554 16912 19173 19172 17246 73902 50883 19167 26441 19171 12530 12649 26442 26440 12428 PI3K EVENTS IN ERBB2 SIGNALING%REACTOME DATABASE ID RELEASE 57%1963642 PI3K events in ERBB2 signaling 13874 12223 211323 83961 100042150 18708 15200 18706 13645 14388 13866 18183 13649 GLUTATHIONE SYNTHESIS AND RECYCLING%REACTOME%R-HSA-174403.2 Glutathione synthesis and recycling 14629 69065 75475 207182 14854 23887 66054 14630 14598 71522 68044 68252 DEFECTIVE SFTPA2 CAUSES IDIOPATHIC PULMONARY FIBROSIS (IPF)%REACTOME%R-HSA-5687868.1 Defective SFTPA2 causes idiopathic pulmonary fibrosis (IPF) 20390 CONSTITUTIVE SIGNALING BY AKT1 E17K IN CANCER%REACTOME%R-HSA-5674400.1 Constitutive Signaling by AKT1 E17K in Cancer 12576 12015 56717 56637 22084 23797 12912 67605 15370 17246 12371 56716 12575 12675 56458 56484 606496 18607 11652 11651 227743 78757 109270 58988 CA-DEPENDENT EVENTS%REACTOME DATABASE ID RELEASE 57%111996 Ca-dependent events 18750 19088 18573 18753 224129 11513 11512 11515 18752 11514 104110 12326 110355 18747 18574 18749 210044 18575 432530 18783 104111 12912 640703 26413 19087 19085 19084 RET SIGNALING%REACTOME%R-HSA-8853659.1 RET signaling 114255 76829 623279 56438 26395 67603 319520 58234 235584 26403 16416 12223 54519 100042150 21894 11600 19060 19186 19188 327826 17169 194231 109905 14161 226525 57296 67151 215449 18710 19185 66998 53380 14172 17967 15461 17463 83409 69077 29875 26417 26413 23939 12323 108058 12322 18015 59029 19197 19417 19184 19179 22190 20422 171463 14573 667035 19182 16590 240057 19181 231474 64654 14173 80903 14164 23997 66997 18039 218397 110135 14585 14178 80857 228769 14180 70247 67089 14586 14587 14175 21762 14177 23996 20416 11876 14165 26554 18596 109880 14389 16399 54153 18708 15200 640703 18706 18673 12325 16706 69601 83379 22371 73902 233046 114716 12981 19415 63953 14174 12982 19252 16653 12984 240672 13537 12988 67836 16186 13385 14588 211323 16184 11836 18188 20740 20739 13645 16185 16452 216869 109689 18176 72399 70686 114715 240168 14268 66413 211255 18183 14083 16451 19192 16453 26445 19166 18218 14812 76089 26444 26446 14811 26443 14813 19414 80297 14814 74769 16183 20742 18707 18709 20741 21687 20743 16367 13866 14810 16192 26396 14360 16191 216148 114713 14186 19418 22123 110351 20662 19052 14170 19053 19262 73699 640524 16913 75590 19175 19177 51792 19713 19170 22330 99571 13874 103554 16912 54401 83961 16188 19173 19172 21770 107971 26932 100986 226849 18611 23980 20418 26931 320484 225849 384783 245684 67112 110157 19167 26441 19419 11472 19171 545987 13649 70727 18595 26442 26440 101809 18591 18750 19247 14783 14786 18803 13448 13449 18747 18749 14388 INHIBITION OF INTERFERON SYNTHESIS%REACTOME DATABASE ID RELEASE 57%168305 Inhibition of Interferon Synthesis DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE%REACTOME%R-HSA-2559586.3 DNA Damage Telomere Stress Induced Senescence 17535 319181 232440 11920 382522 319176 75560 12576 14958 66403 15364 15361 170644 12448 80838 50708 22059 19645 12575 50709 497652 21749 624153 28113 101185 12566 51788 57321 15267 319183 319182 21750 319178 319186 319190 12427 14957 56702 104248 15260 12447 16906 319168 319167 19360 319152 81601 27354 319188 15270 78303 319169 12428 P2Y RECEPTORS%REACTOME%R-HSA-417957.1 P2Y receptors 140795 67168 78826 70839 74191 57385 233571 235036 18441 18442 78134 574402 CATION-COUPLED CHLORIDE COTRANSPORTERS%REACTOME DATABASE ID RELEASE 57%426117 Cation-coupled Chloride cotransporters 20497 57138 20496 107723 20498 20499 20495 SHC1 EVENTS IN ERBB2 SIGNALING%REACTOME DATABASE ID RELEASE 57%1250196 SHC1 events in ERBB2 signaling 13874 20416 12223 211323 83961 100042150 15200 13645 18176 20662 13866 18183 19248 13649 16653 15461 ABACAVIR TRANSPORT AND METABOLISM%REACTOME%R-HSA-2161522.1 Abacavir transport and metabolism 76952 26357 14923 20517 18534 20519 18671 20518 75894 IKBA VARIANT LEADS TO EDA-ID%REACTOME DATABASE ID RELEASE 57%5603029 IkBA variant leads to EDA-ID 18033 18035 16151 18034 16150 12675 19697 REVERSE TRANSCRIPTION OF HIV RNA%REACTOME DATABASE ID RELEASE 57%162589 Reverse Transcription of HIV RNA 268373 VLDL BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 57%8866423 VLDL biosynthesis 17777 18453 11812 11425 238055 PRPP BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 57%73843 PRPP biosynthesis 19139 75456 110639 GLYCOSPHINGOLIPID METABOLISM%REACTOME DATABASE ID RELEASE 57%1660662 Glycosphingolipid metabolism 19156 79554 67902 19025 22234 223753 52635 22239 50877 20598 11881 56356 238011 11883 11886 58911 272636 14667 14466 74008 20597 58994 54447 77041 23943 230101 15212 14421 14420 545260 11605 15211 271970 18010 12091 77626 23956 RETINOID METABOLISM DISEASE EVENTS%REACTOME%R-HSA-6809583.1 Retinoid metabolism disease events 19662 ELONGATION ARREST AND RECOVERY%REACTOME DATABASE ID RELEASE 57%112387 Elongation arrest and recovery 107951 67710 17749 66420 12454 245841 114741 24116 20021 20833 69241 20924 20922 214498 22083 54624 235497 76246 66317 57314 27632 58202 69833 13716 68705 20022 67655 69920 231329 98053 67923 27224 100043714 72949 20020 12455 21399 G1 S TRANSITION%REACTOME%R-HSA-69206.1 G1 S Transition 57813 18973 22171 18538 19891 68240 66413 19192 26445 19166 12576 17187 26444 26446 26443 26965 12572 19645 12575 17420 13555 21781 59001 27401 66979 18974 68275 22123 20459 19052 19053 73699 21402 12567 16913 12447 12443 50793 19175 19177 51792 17869 19170 66671 54124 16912 19173 19172 19167 26441 19171 26442 26440 70024 22390 19186 19188 57296 67151 27214 19185 66998 53380 18392 26428 18393 17463 26429 69077 12448 12544 12545 12534 12566 59029 18969 19075 19184 22190 19179 20422 667035 19182 12427 268930 19181 23997 66997 228769 70247 67089 21762 23996 17215 17219 17217 56452 66634 67177 67141 20135 13361 23834 12530 17216 18968 19076 17220 12428 17218 POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME DATABASE ID RELEASE 57%622327 Postsynaptic nicotinic acetylcholine receptors 11447 11449 231252 11438 110902 110834 108015 11435 11444 110835 11440 108043 11441 11448 VITAMIN C (ASCORBATE) METABOLISM%REACTOME DATABASE ID RELEASE 57%196836 Vitamin C (ascorbate) metabolism 109754 68214 109672 54338 20522 20525 14873 20527 SYNTHESIS OF DOLICHYL-PHOSPHATE MANNOSE%REACTOME%R-HSA-162699.1 Synthesis of dolichyl-phosphate mannose 68563 13481 13480 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL%REACTOME%R-HSA-209560.1 NF-kB is activated and signals survival 18049 18033 18412 18035 16150 22034 22190 18053 667035 19697 16179 EPH-EPHRIN SIGNALING%REACTOME DATABASE ID RELEASE 57%2682334 EPH-Ephrin signaling 11487 54126 11772 11771 59287 545156 71770 53378 16542 14083 15461 13636 13848 14812 13838 270190 13839 17096 13845 13836 57257 13641 13840 13841 56378 13638 13846 230126 12757 232910 12631 22325 13643 13639 13637 11773 13642 71960 13842 15519 13835 67938 66713 18481 14810 14360 67268 13640 13837 224105 19877 19353 56443 11848 17390 11461 16885 19878 17886 67300 218397 17395 13429 22612 18479 76709 16443 11465 73178 13844 68089 74325 208117 74117 67771 11867 16886 19165 216963 100039623 17880 100042305 15529 17974 77579 21844 17904 110596 53972 FGFR2 MUTANT RECEPTOR ACTIVATION%REACTOME DATABASE ID RELEASE 57%1839126 FGFR2 mutant receptor activation 67710 17749 66420 245841 20021 69241 64654 14173 80903 14164 14178 14172 80857 14180 14175 14177 14165 14183 67112 68092 69833 68705 433702 20022 69920 14174 231329 98053 100043714 20020 TWIK-RELEATED ACID-SENSITIVE K+ CHANNEL (TASK)%REACTOME%R-HSA-1299316.1 TWIK-releated acid-sensitive K+ channel (TASK) 223604 16527 LOSS OF FUNCTION OF SMAD2 3 IN CANCER%REACTOME%R-HSA-3304349.1 Loss of Function of SMAD2 3 in Cancer 17127 17128 17126 21803 21813 21812 NETRIN-1 SIGNALING%REACTOME%R-HSA-373752.1 Netrin-1 signaling 19353 20437 19247 26946 18803 22063 22065 14083 18007 17909 17973 22066 73178 69585 20439 20562 22068 18761 68799 210801 244058 20564 22067 22253 216439 223435 18738 330662 13176 319713 226251 22350 107448 231148 14360 18208 20563 19876 57764 107449 DEFECTIVE B3GALT6 CAUSES EDSP2 AND SEMDJL1%REACTOME DATABASE ID RELEASE 57%4420332 Defective B3GALT6 causes EDSP2 and SEMDJL1 15530 14734 14735 13003 12032 20971 103978 20969 11603 20970 121021 15529 13004 12111 29873 14733 71951 13179 23888 CROSSLINKING OF COLLAGEN FIBRILS%REACTOME%R-HSA-2243919.2 Crosslinking of collagen fibrils 21892 24087 16948 18542 16949 94352 16950 67573 12153 INTERLEUKIN-1 SIGNALING%REACTOME%R-HSA-446652.2 Interleukin-1 signaling 266632 107607 22190 26395 108960 16175 26409 26398 667035 26406 192656 17874 18412 16181 68652 21402 66724 22034 66513 93765 103583 73914 16177 12234 26965 240518 12675 18033 54473 26399 231130 16151 16178 67245 16150 257632 93834 66589 16176 26410 16179 RNA POLYMERASE II PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 57%73776 RNA Polymerase II Promoter Escape 67710 68776 66464 21374 17749 66420 245841 235459 209361 66467 20021 69241 99730 319944 24074 108143 229906 83602 270627 14884 66671 228980 68153 74197 23894 12572 226182 216185 17420 13871 13872 209357 69833 14885 68705 72504 20022 69920 21343 231329 98053 407786 100043714 20020 SIGNALING BY FGFR%REACTOME%R-HSA-190236.1 Signaling by FGFR 17346 116701 12402 24064 56438 26395 59013 67603 319520 98758 15382 235584 26403 16416 12223 54519 100042150 21894 11600 19060 19186 19188 327826 17169 194231 109905 14161 226525 57296 67151 215449 18710 19185 66998 53380 14172 17967 15461 17463 83409 69077 29875 12912 26417 26413 68092 433702 12323 108058 12322 18015 59029 19197 19417 19184 14425 22190 19179 20422 171463 667035 14573 19182 16590 240057 19181 64654 231474 14173 80903 14164 23997 66997 18039 218397 110135 14585 14178 80857 228769 14180 70247 67089 14586 14587 14175 21762 14177 23996 20416 11876 14165 26554 18596 109880 16399 54153 18708 15200 640703 18706 18673 12325 16818 16706 69601 83379 22371 73902 233046 114716 12981 19415 63953 14174 12982 19252 16653 12984 240672 13537 12988 67836 16186 13385 14588 211323 16184 11836 18188 20740 20739 13645 16185 16452 216869 109689 18176 72399 70686 114715 240168 14268 66413 211255 18183 14083 16451 19192 16453 26445 19166 18218 12576 14812 76089 26444 26446 14811 26443 14813 19414 80297 14814 12575 74769 16183 20742 18707 18709 20741 21687 20743 16367 13866 14810 16192 26396 14360 16191 216148 114713 14186 19418 22123 20662 19052 14170 19053 19262 73699 640524 16913 75590 19175 19177 51792 19713 19170 22330 99571 13874 103554 16912 54401 83961 56637 16188 19173 19172 21770 107971 26932 100986 226849 18611 23980 20418 26931 320484 225849 384783 12675 245684 67112 110157 19167 26441 19419 11472 19171 545987 13649 70727 18595 26442 26440 101809 18591 18750 19088 16334 67710 76850 18753 17749 18754 66420 236511 245841 19247 16337 75778 15370 18752 104110 229709 20021 12519 69241 12524 76936 77411 21841 93686 19205 606496 69833 68705 20022 69920 231329 98053 21843 14181 72514 100043714 20020 244650 18573 12015 56717 22084 224129 77647 11513 11512 239528 11515 11514 12371 98432 117150 18803 56458 56484 213988 12326 11652 18717 12478 11651 15937 16440 78757 228775 12487 110355 18747 18574 16438 18749 217351 210044 18575 432530 233833 23797 104111 67605 18720 17246 56716 18719 214150 108083 19087 19085 18607 19084 14388 22324 396184 71436 19211 399558 227743 18718 109270 17454 16439 58988 PAUSING AND RECOVERY OF HIV ELONGATION%REACTOME DATABASE ID RELEASE 57%167290 Pausing and recovery of HIV elongation 107951 67710 17749 66420 12454 245841 114741 24116 20021 20833 69241 20924 20922 57314 27632 58202 69833 13716 68705 20022 67655 69920 231329 98053 67923 27224 100043714 72949 20020 12455 21399 ER TO GOLGI ANTEROGRADE TRANSPORT%REACTOME DATABASE ID RELEASE 57%199977 ER to Golgi Anterograde Transport 27096 235416 66890 100042773 11842 67542 20740 11839 20739 333883 193813 11840 56455 77371 59288 104318 245828 20333 80297 67231 20742 11844 20741 20743 107338 70349 13427 67091 13424 12847 110350 74498 69654 56358 228998 67857 56494 215474 50907 53598 213575 108123 108124 69608 640524 66397 213827 21802 214895 11843 12794 76332 59005 234663 70361 22428 217615 67511 102339 317717 14069 338337 16834 68137 67727 14067 20334 16334 233824 218811 54161 76510 12793 66251 77038 56395 19324 105785 21787 56447 13191 20703 68097 18195 53334 54160 50797 78232 69162 12068 56041 56389 52036 66111 76983 66682 14799 99683 56418 66226 207352 110379 224139 99412 76308 89867 227648 13032 338366 66913 64138 60409 97484 11733 11735 216131 67665 243819 12836 72978 59042 105522 54399 14275 100042343 13426 17957 INTERLEUKIN-1 PROCESSING%REACTOME%R-HSA-448706.1 Interleukin-1 processing 18033 18034 16173 16175 16176 12362 19697 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE)%REACTOME%R-HSA-140877.1 Formation of Fibrin Clot (Clotting Cascade) 19152 16621 12261 54368 14723 21788 19128 14729 19123 14724 15160 14161 20720 68891 11905 110135 21824 14060 14066 14061 72461 99571 19124 268591 56744 74145 22371 232345 58992 14068 14058 14071 14069 109821 14062 12258 385643 14067 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 57%68962 Activation of the pre-replicative complex 70024 18973 18969 19075 19891 68240 27214 18392 50793 26428 18393 26429 17215 17219 17217 56452 66634 67177 59001 12544 12545 23834 12566 66979 18974 68275 17216 18968 19076 17220 17218 MTORC1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 57%166208 mTORC1-mediated signalling 54401 56717 13631 66096 667739 67605 56716 74370 13685 13684 54170 208643 245670 545987 68576 68441 66508 83409 52187 75705 BIOLOGICAL OXIDATIONS%REACTOME DATABASE ID RELEASE 57%211859 Biological oxidations 231583 56448 117147 13107 13087 13088 94215 74134 13106 546726 23972 23971 13082 13110 11668 26876 232174 13077 11522 19224 13075 67768 110115 13074 108652 94284 394436 216558 552899 100559 394433 13072 71773 213012 231396 13079 22236 13121 22235 242585 100727 394434 622127 545817 102294 13113 13114 72082 13123 11669 13479 12846 73836 13521 110198 14859 54486 69065 68214 68312 207182 109652 23887 66447 68021 14630 71670 14862 14262 14873 72535 71522 14261 14865 436059 68044 67674 69574 14866 55990 68252 76507 14629 60525 58810 13849 14874 11532 75475 233801 11754 14863 272428 68738 14854 107146 11670 66054 233799 237940 20859 13885 11529 100042314 67758 14598 104158 76263 435528 14872 18984 14871 211666 56615 212503 238505 210009 13116 14149 13070 106648 100040843 72054 108645 19223 13122 269378 18113 29859 23827 17978 11720 109731 56362 104086 17960 17161 20186 20887 22017 17961 57344 20860 13120 320997 20181 232087 76491 631304 13124 13118 21391 64385 17977 208285 13078 13081 244209 13115 71854 319446 107141 13076 71519 18976 72303 68165 14148 56050 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION%REACTOME%R-HSA-1474151.2 Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation 14528 11651 320415 19092 640703 18127 13361 20751 15519 19286 OXIDATIVE DEMETHYLATION OF DNA%REACTOME DATABASE ID RELEASE 57%5221030 Oxidative demethylation of DNA 194388 214133 52463 PYRUVATE METABOLISM%REACTOME DATABASE ID RELEASE 57%70268 Pyruvate metabolism 382051 16828 27402 106557 16833 16832 319518 19015 80879 57274 20501 55951 12215 70456 381511 109801 235339 18604 27273 20181 13382 18597 228026 68263 236900 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION%REACTOME DATABASE ID RELEASE 57%450302 activated TAK1 mediates p38 MAPK activation 26416 107607 17164 108960 26409 26397 192656 26399 16151 68652 66724 19094 257632 102626 22034 66513 16179 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER%REACTOME%R-HSA-2173793.2 Transcriptional activity of SMAD2 SMAD3:SMAD4 heterotrimer 107951 66313 17131 20185 20602 12454 17283 83814 22190 21815 93836 667035 228839 216080 66105 20683 13559 104394 17869 94093 51813 19042 12579 22284 11545 211586 17127 17128 20482 433759 19650 17126 20481 264064 21781 16477 67821 97064 72949 12455 18787 RESOLUTION OF D-LOOP STRUCTURES THROUGH SYNTHESIS-DEPENDENT STRAND ANNEALING (SDSA)%REACTOME%R-HSA-5693554.1 Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) 12190 233826 17535 327762 12021 19364 21975 19360 114714 57434 19362 81601 19363 225182 269400 19361 27354 74335 12189 22427 11920 12144 26909 237911 FORMATION OF APOPTOSOME%REACTOME%R-HSA-111458.1 Formation of apoptosome 11783 670717 12371 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE%REACTOME%R-HSA-168179.1 Toll Like Receptor TLR1:TLR2 Cascade 19094 11596 110651 12475 20210 117149 12234 17164 72349 26965 20111 12912 26400 26417 240518 26413 23939 20112 257632 266632 26420 107607 11909 16476 17260 13712 434174 22190 26414 108960 26395 26409 26401 667035 26398 26397 192656 17874 12491 67603 19052 100040260 19053 319520 73699 12229 26419 68652 11820 21402 66724 102626 22034 20203 66513 17258 24058 93765 12703 51792 26940 103583 21898 73914 26416 21770 12675 19697 21899 18033 26399 18036 231130 18035 17087 16151 18034 73086 16150 67245 93834 13211 66589 14281 24088 26410 21897 235584 16179 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA%REACTOME DATABASE ID RELEASE 57%111447 Activation of BAD and translocation to mitochondria 12015 55948 12122 54401 23797 22631 12043 22629 100039786 22628 19058 11652 11651 22627 19057 FC EPSILON RECEPTOR (FCERI) SIGNALING%REACTOME%R-HSA-2454202.1 Fc epsilon receptor (FCERI) signaling 108723 16822 16428 12042 216150 18018 18019 17096 57257 17444 22325 18021 56743 56438 224105 26420 16476 19353 26414 26395 26401 26398 67603 319520 12229 26419 93765 103583 66589 14281 235584 26403 16416 12223 54519 100042150 21894 11600 19060 19186 19188 327826 17169 194231 100041766 216080 109905 14161 226525 57296 67151 215449 18710 19185 66998 53380 14172 19395 17967 15461 17463 83409 69077 29875 12234 12912 26400 26417 26413 12323 108058 12322 18015 59029 19197 19417 19184 22190 19179 20422 26409 171463 667035 14573 19182 16590 22165 240057 19181 64654 231474 14173 80903 19056 14164 23997 19055 66997 68652 18039 66724 218397 22034 110135 66513 14585 240354 14178 14126 80857 228769 14180 70247 67089 14125 14586 14587 14175 21762 14177 23996 20416 11876 14165 26554 14127 18596 109880 14389 16399 54153 18708 18761 15200 640703 18706 18673 12325 16818 16706 69601 83379 22371 19058 73902 233046 114716 12981 19415 63953 14174 12982 19252 16653 12984 240672 13537 12988 21682 67836 16186 13385 14588 211323 16184 11836 20963 18188 20740 20739 13645 16185 16452 216869 109689 18176 72399 70686 114715 240168 14268 66413 211255 18183 14083 16451 19192 16453 26445 19166 18218 12576 14812 76089 26444 26446 14811 26965 26443 14813 19414 80297 14814 12575 74769 16183 20742 18707 18709 20741 21687 20743 16367 13866 14810 16192 26396 14360 16191 216148 114713 14186 19418 22123 20662 19052 14170 19053 19262 73699 640524 21402 16913 75590 19175 19177 51792 19713 19170 22330 99571 13874 103554 16912 54401 83961 56637 16188 19173 19172 21770 107971 26932 100986 226849 18611 23980 20418 26931 320484 225849 384783 12675 245684 19697 67112 18033 110157 19167 18035 26441 16151 19419 11472 16150 19171 545987 13649 70727 18595 26442 26440 101809 18591 16334 76850 236511 19247 16337 75778 15370 229709 12519 12524 606496 244650 12015 56717 22084 77647 239528 12371 98432 117150 18803 56458 234779 56484 213988 11652 18717 12478 11651 15937 16440 18479 78757 228775 12487 16438 217351 233833 23797 67605 18720 17246 56716 18719 214150 108083 18607 14388 22324 19211 227743 18718 109270 17454 16439 58988 MITOCHONDRIAL UNCOUPLING PROTEINS%REACTOME DATABASE ID RELEASE 57%166187 Mitochondrial Uncoupling Proteins 74011 22227 20523 22228 22229 RESOLUTION OF ABASIC SITES (AP SITES)%REACTOME%R-HSA-73933.1 Resolution of Abasic Sites (AP sites) 22594 18973 19687 382913 69263 17193 67967 19718 71726 18207 18294 18972 18538 19891 69745 68240 18971 16882 70603 268395 26430 11792 18970 11545 16881 14156 11546 59047 59001 72151 106344 66979 18974 68275 72774 FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC%REACTOME%R-HSA-389960.1 Formation of tubulin folding intermediates by CCT TriC 12466 545486 22153 12467 238463 12469 73710 227613 22143 22151 22147 12465 22142 67951 21454 12462 22146 12461 53857 12464 12468 22152 22145 SIGNALLING TO RAS%REACTOME%R-HSA-167044.2 Signalling to RAS 56438 26395 67603 319520 102626 235584 26403 16416 12223 54519 100042150 21894 11600 19060 19186 19188 327826 17169 194231 109905 14161 226525 57296 67151 215449 19185 66998 53380 14172 17967 15461 17463 83409 69077 29875 17164 26417 26413 12323 108058 12322 18015 59029 19197 19417 19184 19179 22190 20422 171463 14573 667035 19182 16590 240057 19181 231474 64654 80903 14173 23997 14164 66997 18039 218397 110135 14585 14178 80857 228769 14180 70247 67089 14586 14587 14175 21762 14177 23996 20416 11876 14165 26554 18596 109880 16399 54153 15200 640703 18673 12325 16706 69601 83379 22371 73902 233046 114716 12981 19415 63953 14174 12982 19252 16653 12984 240672 13537 12988 67836 16186 13385 14588 211323 16184 11836 18188 20740 20739 13645 16185 16452 216869 109689 18176 18049 72399 70686 18211 114715 240168 14268 66413 211255 18183 14083 16451 19192 16453 26445 19166 56044 18218 14812 76089 26444 26446 14811 26443 14813 19414 80297 14814 16183 20742 20741 21687 20743 16367 13866 14810 16192 26396 14360 16191 216148 114713 14186 19418 22123 20662 19052 14170 19053 19262 73699 640524 16913 75590 19175 19177 51792 19713 19170 22330 99571 13874 103554 16912 26416 54401 83961 16188 19173 19172 21770 26932 107971 226849 100986 18611 23980 20418 26931 225849 320484 384783 245684 67112 110157 19167 26441 19419 11472 19171 545987 13649 70727 18595 26442 26440 101809 18591 29857 19094 26415 19730 64143 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL%REACTOME DATABASE ID RELEASE 57%1855167 Synthesis of pyrophosphates in the cytosol 27399 327655 271424 102954 56409 227399 71207 217837 75678 SCAVENGING OF HEME FROM PLASMA%REACTOME%R-HSA-2168880.1 Scavenging of heme from plasma 11699 15458 11806 16971 15439 11657 15122 15129 93671 16069 OPIOID SIGNALLING%REACTOME DATABASE ID RELEASE 57%111885 Opioid Signalling 18750 18796 19088 18795 18753 18752 104110 229709 14706 14678 14696 14677 14679 12568 14688 14708 18798 14693 18797 14709 14697 18783 19045 12912 26413 242851 19057 18573 224129 11513 11512 11515 11514 18610 18390 19052 19053 19056 73699 19055 12326 16440 51792 110355 18747 18976 18574 16438 110385 14699 18749 18577 66066 14700 210044 14701 18575 432530 238871 21770 104111 14695 640703 18578 14704 14702 14710 64337 19087 19085 19058 19084 14681 14685 19049 14686 14687 16439 14680 TRANSLESION SYNTHESIS BY POLK%REACTOME%R-HSA-5655862.1 Translesion synthesis by POLK 19687 69263 27015 19718 22190 56210 18538 19891 667035 68240 71890 19714 72151 106344 68275 MULTIFUNCTIONAL ANION EXCHANGERS%REACTOME DATABASE ID RELEASE 57%427601 Multifunctional anion exchangers 231583 23985 171429 320718 208890 13521 13487 DUAL INCISION IN TC-NER%REACTOME DATABASE ID RELEASE 57%6782135 Dual incision in TC-NER 72584 18973 19687 67710 69263 67967 19718 17749 66420 99375 245841 18972 13194 18538 19891 66467 69745 20021 68240 69241 18971 14884 56031 319955 27015 12572 17420 59001 72151 69833 106344 20022 66979 69920 18974 56438 231329 68275 100043714 20020 328572 22190 667035 66983 71101 71991 67439 66671 57905 22592 50505 13870 23894 22590 13871 13872 209357 11834 14885 252870 21399 28000 ACTIVATION OF C3 AND C5%REACTOME DATABASE ID RELEASE 57%174577 Activation of C3 and C5 12266 625018 12263 15139 14962 TCF7L2 MUTANTS DON'T BIND CTBP%REACTOME%R-HSA-5339700.2 TCF7L2 mutants don't bind CTBP 13017 21416 13016 WNT MEDIATED ACTIVATION OF DVL%REACTOME%R-HSA-201688.1 WNT mediated activation of DVL 13000 13543 100039026 27373 13542 13001 13544 18719 VITAMINS%REACTOME DATABASE ID RELEASE 57%211916 Vitamins 232174 13081 244209 546726 13115 13082 MASTL FACILITATES MITOTIC PROGRESSION%REACTOME DATABASE ID RELEASE 57%2465910 MASTL Facilitates Mitotic Progression 19052 19053 73699 12534 67121 52432 51792 56205 59046 APEX1-INDEPENDENT RESOLUTION OF AP SITES VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 57%5649702 APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway 59047 22594 382913 18970 18294 72774 16882 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION%REACTOME DATABASE ID RELEASE 57%948021 Transport to the Golgi and subsequent modification 27096 235416 66890 100042773 11842 67542 20740 11839 20739 333883 193813 11840 56455 56386 57370 56375 77371 53418 59288 56336 104318 245828 20333 80297 67231 20742 11844 20741 17156 68947 20743 107338 70349 12640 13427 67091 12847 13424 16866 110350 74498 69654 56358 71665 228998 215474 56494 67857 50907 53598 14595 107895 213575 17308 108123 69608 108124 640524 66397 20451 213827 214895 21802 11843 12794 76332 59005 217664 17309 234663 70361 22428 217615 67511 67569 102339 317717 14069 242362 338337 16834 68137 67727 14067 20334 16334 218811 233824 76510 54161 12793 66251 56395 77038 19324 269181 105785 17155 21787 56447 13191 53618 68097 20703 18195 53334 54160 50797 78232 230815 69162 12068 56041 56389 52036 66111 76983 66682 14799 56418 99683 66226 207352 110379 224139 99412 76308 89867 103534 227648 13032 98388 338366 66913 64138 60409 17158 97484 11733 11735 216131 20450 67665 243819 12836 72978 59042 105522 54399 14275 241230 100042343 20443 13426 17957 20440 ROLE OF SECOND MESSENGERS IN NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 57%418890 Role of second messengers in netrin-1 signaling 22066 13176 22063 22065 22068 26946 18208 22067 18803 18738 FATTY ACIDS%REACTOME%R-HSA-211935.1 Fatty acids 56448 106648 100040843 72054 13107 13087 13088 13110 13120 320997 631304 13118 64385 208285 PI3K AKT SIGNALING IN CANCER%REACTOME%R-HSA-2219528.1 PI3K AKT Signaling in Cancer 12223 211323 100042150 19247 13645 15370 327826 12519 12524 18710 18183 14172 12576 12912 12575 74769 18707 18709 606496 16367 13866 14360 14186 12015 56717 22084 77647 12371 16590 56458 64654 56484 80903 14173 14170 14164 11652 12478 11651 14178 80857 78757 14180 12487 14175 14177 13874 14165 18596 56637 83961 18708 23797 15200 67605 18706 17246 56716 16818 384783 12675 83379 67112 18607 14388 22324 14174 13649 18595 227743 109270 18591 58988 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION%REACTOME%R-HSA-156827.1 L13a-mediated translational silencing of Ceruloplasmin expression 76808 68028 100043755 19899 67186 20115 57294 667739 67025 27370 65019 67248 666669 100038991 100038875 100040021 432502 66481 100040298 238217 56040 667618 19989 66235 55944 13669 27979 68135 66085 26905 22384 53356 56347 13684 67204 223691 13682 73830 16341 100042807 13681 54709 75705 98221 13665 208643 18458 67891 100042986 100042740 621100 100043295 67097 100043000 625646 67281 633683 667035 666899 16785 100039316 267019 100040970 19941 382492 20055 19951 100042670 68193 665189 668182 19921 20044 668144 100043423 100043893 670832 100043876 629957 225058 22121 75617 667279 76846 27050 100043184 19934 100040331 100043391 319195 68172 241053 100043209 20102 67941 27207 668668 20103 672214 622534 20085 20084 TRANSPORT AND SYNTHESIS OF PAPS%REACTOME DATABASE ID RELEASE 57%174362 Transport and synthesis of PAPS 231583 73836 23972 13521 23971 108652 THYROXINE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 57%209968 Thyroxine biosynthesis 13370 22018 13371 12640 214593 70337 114479 107585 99439 22094 BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS%REACTOME DATABASE ID RELEASE 57%390247 Beta-oxidation of very long chain fatty acids 170789 11666 12908 113868 15488 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME%REACTOME DATABASE ID RELEASE 57%975155 MyD88 dependent cascade initiated on endosome 19094 11596 110651 20210 12234 17164 72349 26965 20111 12912 26400 26417 240518 26413 23939 20112 257632 81897 266632 26420 170743 107607 11909 54123 16476 17260 170744 13712 434174 22190 26414 108960 26395 26409 26401 667035 26398 72162 26397 192656 17874 67603 19052 100040260 19053 319520 73699 26419 68652 11820 21402 66724 102626 22034 20203 66513 17258 93765 51792 26940 103583 26416 21770 12675 19697 18033 26399 18036 231130 18035 16151 18034 73086 16150 67245 93834 13211 66589 14281 26410 235584 16179 PI3K EVENTS IN ERBB4 SIGNALING%REACTOME%R-HSA-1250342.1 PI3K events in ERBB4 signaling 211323 13645 18183 12576 12575 74769 18707 18709 16367 13866 14360 14186 19052 14170 19053 73699 51792 13874 56637 83961 21770 26932 226849 26931 225849 384783 12675 67112 13649 18595 18591 12223 16334 76850 100042150 236511 19247 16337 75778 15370 327826 12519 12524 18710 14172 12912 26417 26413 606496 244650 12015 56717 22084 77647 239528 12371 98432 16590 117150 64654 56458 14173 56484 80903 14164 213988 11652 18717 12478 11651 15937 14178 80857 14180 78757 228775 12487 14175 14177 217351 14165 18596 233833 23797 18708 15200 67605 18706 18720 17246 56716 16818 18719 214150 108083 83379 18607 14388 22324 14174 19211 227743 18718 109270 17454 58988 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A%REACTOME DATABASE ID RELEASE 57%69601 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A 19186 19188 57296 67151 66413 19185 11920 66998 53380 19192 17463 26445 19166 69077 26444 26446 26443 22123 59029 19184 19179 22190 20422 667035 19182 19181 23997 66997 16913 228769 70247 19175 67089 19177 19170 21762 23996 103554 16912 19173 19172 73902 19167 50883 26441 12530 19171 12649 26442 26440 AMPLIFICATION OF SIGNAL FROM THE KINETOCHORES%REACTOME%R-HSA-141424.1 Amplification of signal from the kinetochores 17120 56150 SIGNALING BY NODAL%REACTOME DATABASE ID RELEASE 57%1181150 Signaling by NODAL 18119 620395 269275 13590 18550 11481 17128 17127 17126 66556 14106 18553 56484 12622 320202 11479 11480 PROTON OLIGOPEPTIDE COTRANSPORTERS%REACTOME DATABASE ID RELEASE 57%427975 Proton oligopeptide cotransporters 57738 65221 56643 100561 NUCLEAR SIGNALING BY ERBB4%REACTOME DATABASE ID RELEASE 57%1251985 Nuclear signaling by ERBB4 12223 211323 20185 18667 11491 100042150 19247 19109 20315 16452 59287 68652 21402 18183 20203 14600 13982 19116 13874 20851 20850 83961 12234 208117 26965 15200 22601 80707 19165 100039623 100042305 56438 14580 12991 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY%REACTOME%R-HSA-110373.1 Resolution of AP sites via the multiple-nucleotide patch replacement pathway 26430 18973 11792 19687 69263 18970 11545 67967 16881 19718 14156 11546 18972 18538 19891 69745 68240 18971 59001 72151 106344 66979 18974 68275 TFAP2 (AP-2) FAMILY REGULATES TRANSCRIPTION OF GROWTH FACTORS AND THEIR RECEPTORS%REACTOME%R-HSA-8866910.1 TFAP2 (AP-2) family regulates transcription of growth factors and their receptors 21418 13866 12640 22632 22339 13982 21802 21420 16590 21419 MITOCHONDRIAL TRANSLATION%REACTOME DATABASE ID RELEASE 57%5368287 Mitochondrial translation 56284 56282 24030 320806 14548 67707 94061 69956 94067 107734 68611 67681 28030 74600 78523 66419 60441 56280 121022 69527 66407 77721 66230 68537 67994 28028 64655 66242 68565 69163 76366 67840 68735 27398 67871 65111 216767 67308 66047 52443 66163 64657 69606 99045 118451 108853 64656 79044 76784 59054 27397 66493 67036 218506 94063 353242 64660 68499 66973 75398 107732 66223 27393 68836 67212 18120 66121 50529 66258 57312 623346 232536 102060 94062 64659 107733 68463 622268 66845 66399 66077 94065 66292 233870 100042811 66448 18100 94066 64658 68572 100040519 CARBOHYDRATE METABOLISM%REACTOME%R-HSA-71387.5 Carbohydrate metabolism 231583 14734 15118 15478 212898 15476 195646 15116 17423 50787 70484 27029 64580 110006 11603 23972 23971 11881 218271 328779 233781 628779 14735 338362 280645 80982 20544 114332 15531 23908 54371 319415 83398 108652 15587 12505 108902 50785 15212 54710 117592 15211 27419 56398 15586 72136 14043 56773 545291 14042 78830 13358 72157 230163 14447 27376 109685 14751 14387 11674 74185 13853 102093 319901 50799 76969 12183 15931 26384 93683 27416 14719 15442 110094 50786 18679 15117 74551 110078 76898 53412 72727 14718 73836 17449 71951 18563 15932 13806 217119 110095 23888 19309 13521 18639 73744 100043349 17160 18640 110173 170768 17159 67863 13807 13808 18534 77559 14120 67980 58866 226413 18642 270198 11722 18641 100043686 105193 69983 56421 232714 66681 58810 21991 18655 15366 72141 68961 14121 18682 27357 15275 15277 232493 14936 14733 11676 18648 56012 212032 103978 78923 121021 74241 269941 58250 13004 12111 29873 60322 77590 13179 234356 71797 74246 14635 59031 13003 14430 53374 78752 12032 22190 20528 75612 667035 225913 11677 54613 640703 192188 21881 21351 17448 11668 56386 57370 56375 53418 56336 216558 227327 12091 14595 110639 232449 19895 66646 71884 19052 72297 19053 73699 81600 51792 75456 56636 21770 19139 110208 66171 218210 66679 18226 69912 227720 54563 223921 103468 70699 72787 18663 103988 231727 14264 18295 20322 269113 235582 231042 27047 234865 16548 116847 69736 16545 19069 17022 107939 170762 59015 227699 18141 445007 108989 19386 16770 69482 71805 53625 20971 20969 20537 14385 14377 64452 231103 20526 56485 18747 15530 18749 102448 67880 68631 20525 68401 230612 246787 14378 53881 20970 20527 15529 20442 20443 14381 20444 DISORDERS OF TRANSMEMBRANE TRANSPORTERS%REACTOME DATABASE ID RELEASE 57%5619115 Disorders of transmembrane transporters 67819 66753 19186 19188 269523 57296 67151 103988 66413 19185 66998 53380 19192 20338 26445 20390 17463 19166 20389 12638 20388 69077 20387 193670 54197 26444 116891 26446 216440 26443 16514 11998 22123 12000 59029 19184 19179 22190 20422 667035 19182 19181 26361 23997 66997 231103 54140 16913 228769 70247 19175 67089 19177 19170 21762 23996 103554 16912 19173 19172 244373 73902 19167 26441 19171 11657 70377 20927 26442 226144 26440 HDL-MEDIATED LIPID TRANSPORT%REACTOME DATABASE ID RELEASE 57%194223 HDL-mediated lipid transport 18749 27801 110611 232345 93835 65969 11806 11814 11657 11303 11813 11307 16816 18747 11816 NR1D1 (REV-ERBA) REPRESSES GENE EXPRESSION%REACTOME%R-HSA-1368071.2 NR1D1 (REV-ERBA) represses gene expression 20185 217166 15183 FORMATION OF THE ACTIVE COFACTOR, UDP-GLUCURONATE%REACTOME DATABASE ID RELEASE 57%173599 Formation of the active cofactor, UDP-glucuronate 216558 22235 242585 PTK6 REGULATES CELL CYCLE%REACTOME DATABASE ID RELEASE 57%8849470 PTK6 Regulates Cell Cycle 12576 12566 20459 12567 12447 12443 HYALURONAN METABOLISM%REACTOME%R-HSA-2142845.1 Hyaluronan metabolism 15118 109685 15116 80982 20544 114332 192188 110006 15587 12505 15366 27416 15212 15211 15117 56398 15586 DISPLACEMENT OF DNA GLYCOSYLASE BY APEX1%REACTOME%R-HSA-110357.1 Displacement of DNA glycosylase by APEX1 70603 11792 17193 71726 18207 18294 268395 FGFR2 ALTERNATIVE SPLICING%REACTOME%R-HSA-6803529.1 FGFR2 alternative splicing 67710 17749 66420 245841 59013 20021 69241 98758 76936 77411 21841 93686 19205 68092 69833 433702 68705 20022 69920 15382 231329 21843 98053 100043714 20020 WAX BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 57%8848584 Wax biosynthesis 245532 67420 245533 330450 SIGNALING BY LIGAND-RESPONSIVE EGFR VARIANTS IN CANCER%REACTOME%R-HSA-5637815.1 Signaling by Ligand-Responsive EGFR Variants in Cancer 20416 18708 22190 18706 13645 667035 12402 15519 18176 18803 20662 12539 14388 13649 16653 15461 METABOLISM OF SEROTONIN%REACTOME%R-HSA-380612.2 Metabolism of serotonin 17161 11669 DISSOLUTION OF FIBRIN CLOT%REACTOME%R-HSA-75205.1 Dissolution of Fibrin Clot 18788 18816 20719 18792 20725 20720 94175 18793 20194 18815 18791 12306 18787 MYD88-INDEPENDENT TLR3 TLR4 CASCADE%REACTOME DATABASE ID RELEASE 57%166166 MyD88-independent TLR3 TLR4 cascade 19247 22031 11797 100041766 216080 66105 19094 11796 54131 11596 110651 12475 20210 12234 21353 17164 72349 26965 20111 56489 12912 26400 26417 26413 23939 20112 257632 26420 107607 56480 11909 16476 54123 17260 13712 434174 14082 22190 26414 108960 26395 26409 667035 26398 12370 26397 192656 19766 17874 67603 19052 100040260 19053 319520 73699 26419 68652 11820 21402 66724 102626 22034 20203 66513 17258 93765 51792 103583 21898 106759 26416 142980 225471 56532 21770 12675 19697 18033 26399 18036 231130 18035 17087 16151 18034 73086 16150 13211 66589 14281 26410 235584 16179 BASE EXCISION REPAIR%REACTOME%R-HSA-73884.1 Base Excision Repair 22594 18973 19687 382913 69263 17193 67967 19718 71726 18207 18294 18972 18538 19891 69745 68240 18971 16882 70603 268395 26430 11792 18970 11545 16881 14156 11546 59047 59001 72151 106344 66979 18974 68275 72774 FGFR1 LIGAND BINDING AND ACTIVATION%REACTOME%R-HSA-190242.2 FGFR1 ligand binding and activation 64654 67112 14173 14165 14164 14174 80857 14180 14175 14177 UNCOATING OF THE HIV VIRION%REACTOME%R-HSA-162585.1 Uncoating of the HIV Virion 268373 SIGNALING BY FGFR4 IN DISEASE%REACTOME DATABASE ID RELEASE 57%5655291 Signaling by FGFR4 in disease 20662 14388 18708 18706 16653 15461 327826 14186 18803 18176 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS%REACTOME%R-HSA-2029485.1 Role of phospholipids in phagocytosis 16438 14131 246256 18753 18754 20963 18708 18706 74769 229709 14129 18807 104759 18803 18805 234779 381925 18709 18806 53357 12502 16440 71910 16439 INITIAL TRIGGERING OF COMPLEMENT%REACTOME DATABASE ID RELEASE 57%166663 Initial triggering of complement 71693 239447 12260 667277 317677 12944 14962 11537 12266 625018 12263 12259 17195 14134 12262 16904 SYNTHESIS OF 12-EICOSATETRAENOIC ACID DERIVATIVES%REACTOME%R-HSA-2142712.1 Synthesis of 12-eicosatetraenoic acid derivatives 625249 11686 11684 14775 14776 11687 P75NTR REGULATES AXONOGENESIS%REACTOME DATABASE ID RELEASE 57%193697 p75NTR regulates axonogenesis 18049 192662 17136 11848 18377 18053 68585 235402 16801 TRANSLESION SYNTHESIS BY POLI%REACTOME%R-HSA-5656121.1 Translesion synthesis by POLI 19687 69263 19718 22190 56210 18538 19891 667035 68240 71890 19714 72151 106344 68275 26447 HDMS DEMETHYLATE HISTONES%REACTOME DATABASE ID RELEASE 57%3214842 HDMs demethylate histones 216850 193796 230674 76804 75605 99982 22289 225876 20591 18676 218214 77035 15077 338523 20592 71371 320595 214899 277250 319149 244694 104263 107817 30841 SMOOTH MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 57%445355 Smooth Muscle Contraction 26903 20410 21894 19303 11475 17907 12391 17898 22004 20411 59310 11749 16952 12306 93689 22330 216459 59069 640703 434246 109700 67938 16419 17880 67268 107589 17904 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER%REACTOME DATABASE ID RELEASE 57%6782210 Gap-filling DNA repair synthesis and ligation in TC-NER 72584 18973 19687 67710 69263 67967 19718 17749 66420 99375 245841 18972 13194 18538 19891 66467 69745 20021 68240 69241 18971 14884 56031 319955 27015 16881 12572 17420 59001 72151 69833 106344 20022 66979 69920 18974 56438 231329 68275 100043714 20020 22594 328572 22190 667035 66983 71101 71991 16882 67439 66671 57905 23894 13871 13872 209357 11834 14885 252870 21399 28000 TNFR1-INDUCED NFKAPPAB SIGNALING PATHWAY%REACTOME DATABASE ID RELEASE 57%5357956 TNFR1-induced NFkappaB signaling pathway 22030 74256 53376 229603 30941 21937 26409 21926 22258 11797 71609 19766 21929 68652 66724 11796 66513 24105 268749 22029 106025 12675 16151 16150 14694 11798 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS%REACTOME%R-HSA-390471.1 Association of TriC CCT with target proteins during biosynthesis 108077 24128 14447 27055 99371 55946 216853 30839 66887 20698 213980 20848 12447 30838 30050 15183 12466 12467 12469 14466 12448 22059 242960 12465 50754 21454 50789 12462 12461 12464 16553 12468 67134 68628 236733 71833 106052 50762 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS)%REACTOME DATABASE ID RELEASE 57%456926 Thrombin signalling through proteinase activated receptors (PARs) 216869 109689 14706 14696 14688 14708 14693 14061 14709 14697 14699 14682 66066 14675 14700 14701 14676 14672 14674 14695 14704 26417 14702 26413 14065 14710 64337 14062 14673 14064 CARGO TRAFFICKING TO THE PERICILIARY MEMBRANE%REACTOME%R-HSA-5620920.1 Cargo trafficking to the periciliary membrane 19889 74025 12879 56350 106840 13196 18764 18763 68146 12469 211446 20336 53413 215445 12465 21454 12462 12461 12464 102058 107338 319757 212541 17274 53869 107371 105504 11843 64436 71492 69940 233649 52028 72569 76260 93730 216363 66482 20607 71769 207911 319845 67378 56297 102774 59030 18582 241950 12789 MITOTIC METAPHASE ANAPHASE TRANSITION%REACTOME%R-HSA-68881.1 Mitotic Metaphase Anaphase Transition 18817 67141 SIGNALING BY FGFR3 POINT MUTANTS IN CANCER%REACTOME%R-HSA-8853338.1 Signaling by FGFR3 point mutants in cancer 14184 18708 18706 327826 18803 18176 20662 64654 14173 80903 14164 14388 14172 80857 14180 16653 15461 14175 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%R-HSA-5250941.1 Negative epigenetic regulation of rRNA expression 100041953 17749 66420 245841 319181 50724 66467 232440 93762 14884 20937 382522 319176 269003 433759 15182 12572 93759 20467 94246 17420 13433 624153 13436 69833 625328 51788 15077 60406 319149 17191 100043714 66136 21341 21340 15267 20017 319183 21374 70333 667501 22130 57230 319182 319178 319186 319190 21429 75316 64424 20016 20018 20019 319168 21339 66671 319167 71954 20466 23894 13871 13872 209357 14885 101867 319188 15270 319169 78303 116848 SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX)%REACTOME%R-HSA-2162123.1 Synthesis of Prostaglandins (PG) and Thromboxanes (TX) 64292 12408 54486 19223 96979 15446 19215 100043508 66469 105349 67103 19225 19224 13124 21391 CONSTITUTIVE SIGNALING BY LIGAND-RESPONSIVE EGFR CANCER VARIANTS%REACTOME%R-HSA-1236382.1 Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants 20416 18708 22190 18706 13645 667035 12402 15519 18176 18803 20662 12539 14388 13649 16653 15461 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING%REACTOME DATABASE ID RELEASE 57%512988 Interleukin-3, 5 and GM-CSF signaling 12402 17096 56438 26395 67603 319520 235584 26403 16416 12223 54519 100042150 21894 11600 19060 19186 19188 327826 17169 194231 109905 14161 226525 57296 67151 215449 18710 19185 66998 53380 14172 17967 15461 17463 83409 69077 29875 22631 26417 26413 12323 108058 12322 18015 59029 19197 19417 19184 19179 22190 20422 171463 14573 667035 19182 16590 240057 19181 231474 64654 80903 14173 14164 23997 66997 18039 218397 110135 14585 14178 80857 228769 14180 70247 67089 14586 14587 14175 21762 14177 23996 20416 11876 20851 14165 26554 18596 20850 17060 109880 14389 16399 54153 18708 15200 640703 18706 18673 12325 16706 69601 83379 22371 73902 233046 114716 12981 19415 63953 14174 12982 19252 16653 12984 240672 13537 12988 67836 21682 16186 13385 14588 211323 16184 11836 20963 18188 20740 20739 13645 16185 16452 216869 109689 18176 72399 70686 114715 240168 14268 66413 211255 18183 14083 16451 19192 16453 26445 19166 16331 18218 15170 14812 76089 16332 26444 26446 14811 26443 14813 19414 80297 14814 74769 16183 20742 18707 18709 20741 21687 20743 16367 13866 14810 16192 26396 14360 16191 216148 114713 14186 19418 22123 20662 19052 14170 19053 19262 73699 640524 16913 75590 19175 19177 51792 19713 19170 22330 99571 13874 103554 16912 54401 83961 16188 19173 19172 21770 107971 26932 100986 226849 18611 23980 20418 26931 320484 225849 384783 245684 67112 110157 19167 26441 19419 11472 19171 545987 13649 70727 18595 26442 26440 101809 18591 19247 12929 12928 22612 18747 15162 107746 22324 PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME DATABASE ID RELEASE 57%622323 Presynaptic nicotinic acetylcholine receptors 11447 11449 11438 110834 110902 11435 108015 110835 11444 11440 108043 11448 BETA OXIDATION OF MYRISTOYL-COA TO LAUROYL-COA%REACTOME%R-HSA-77285.1 Beta oxidation of myristoyl-CoA to lauroyl-CoA 231086 97212 11363 TICAM1 DEFICIENCY - HSE%REACTOME%R-HSA-5602566.1 TICAM1 deficiency - HSE 106759 142980 INTERLEUKIN-12 SIGNALING%REACTOME%R-HSA-447115.1 Interleukin-12 signaling 16162 16160 16161 16159 EFFECTS OF PIP2 HYDROLYSIS%REACTOME DATABASE ID RELEASE 57%114508 Effects of PIP2 hydrolysis 18753 23945 18754 26946 22065 19395 16440 16438 18761 22068 18755 331374 56077 66082 320127 380921 110524 104418 19419 13139 110197 76192 231871 269060 16439 217480 ROLE OF ABL IN ROBO-SLIT SIGNALING%REACTOME%R-HSA-428890.1 Role of Abl in Robo-Slit signaling 76499 76707 20563 12331 14733 19876 67252 11350 11352 SUMO IS PROTEOLYTICALLY PROCESSED%REACTOME%R-HSA-3065679.1 SUMO is proteolytically processed 75826 100043429 320213 223870 20610 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1%REACTOME DATABASE ID RELEASE 57%174178 APC C:Cdh1 mediated degradation of Cdc20 and other APC C:Cdh1 targeted proteins in late mitosis early G1 66156 52206 668450 18817 19186 22194 19188 75430 216080 57296 67151 66413 19185 66998 53380 52717 19192 20878 26445 17463 19166 69077 26444 26446 26443 52563 99152 20877 27401 69957 68999 68612 17222 22123 59029 19184 19179 22190 20422 667035 19182 56371 19181 23997 66997 16913 228769 19175 70247 19177 67089 19170 21762 23996 103554 16912 19173 19172 59008 56317 73902 19167 26441 107995 19171 217232 26442 26440 30939 IRAK4 DEFICIENCY (TLR2 4)%REACTOME%R-HSA-5603041.1 IRAK4 deficiency (TLR2 4) 21899 266632 12475 12229 17087 117149 24088 21897 17874 21898 12491 PHOSPHORYLATION OF PROTEINS INVOLVED IN G1 S TRANSITION BY ACTIVE CYCLIN E:CDK2 COMPLEXES%REACTOME DATABASE ID RELEASE 57%69200 Phosphorylation of proteins involved in G1 S transition by active Cyclin E:Cdk2 complexes 12566 12448 12447 19645 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE%REACTOME%R-HSA-204998.1 Cell death signalling via NRAGE, NRIF and NADE 54126 18049 59287 545156 224014 269608 101497 13605 94275 75547 26382 16800 57257 67733 22325 19418 12015 12367 19353 22190 236915 667035 20662 18412 26419 22034 12366 22627 71704 213498 102098 16443 277360 226970 207212 20663 73341 208117 56349 18053 12125 171207 24001 223435 109904 19165 12070 100039623 100042305 56321 22324 109934 69632 30938 21844 17207 230972 213649 53972 14163 DEFECTIVE EXT1 CAUSES EXOSTOSES 1, TRPS2 AND CHDS%REACTOME DATABASE ID RELEASE 57%3656253 Defective EXT1 causes exostoses 1, TRPS2 and CHDS 15530 14734 14735 15529 20971 103978 20969 14733 71951 11603 23888 20970 DNA DOUBLE-STRAND BREAK REPAIR%REACTOME%R-HSA-5693532.1 DNA Double-Strand Break Repair 18973 19687 69263 67967 19718 18972 18538 19891 69745 68240 18971 93762 27015 80905 77782 75570 11350 59001 72151 106344 66979 56196 18974 51869 68275 104884 54125 14375 22594 319583 16882 26419 100043429 93765 22385 108138 26909 17535 100039592 12021 319181 19060 70620 15204 70681 240087 74335 12189 11920 231724 382522 237911 70238 210766 327762 27223 11545 21975 14156 22059 11546 19355 20184 19367 12566 269582 59004 22427 19356 12144 235559 319183 14048 14049 22190 56626 193796 319182 319178 230674 667035 319186 14051 55982 319190 14050 227525 12427 11785 107823 12190 52864 233826 22196 268465 50505 19364 19365 13870 19360 235610 114714 107976 57434 319152 224008 104416 68251 209334 19362 81601 71711 19363 225182 269400 27354 19361 15574 19822 50883 22596 319188 232314 15270 19090 12649 56420 78303 66131 21853 12428 50721 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING%REACTOME DATABASE ID RELEASE 57%879415 Advanced glycosylation endproduct receptor signaling 11596 16854 20210 11820 13200 434174 20203 19089 26417 12340 26413 12343 FACILITATIVE NA+-INDEPENDENT GLUCOSE TRANSPORTERS%REACTOME DATABASE ID RELEASE 57%428790 Facilitative Na+-independent glucose transporters 117591 56017 435818 227659 20526 56485 170441 353169 20525 20528 56636 20527 VEGF BINDS TO VEGFR LEADING TO RECEPTOR DIMERIZATION%REACTOME%R-HSA-195399.1 VEGF binds to VEGFR leading to receptor dimerization 16542 22341 18654 22339 22340 14205 14254 14257 SIGNALING BY NOTCH%REACTOME%R-HSA-157118.1 Signaling by NOTCH 18519 18550 216869 109689 59287 54485 13388 16450 16449 433586 211586 26965 15182 13557 13555 21781 14128 17242 56438 18222 19719 140484 16848 17305 12914 16476 328572 15251 18011 14595 224143 21402 12443 21372 17869 11938 19664 53313 11937 18131 18129 18128 18132 11487 76850 14357 227325 13386 236511 56233 11491 74198 333639 207521 12805 20338 103806 79221 170787 225164 208727 15208 240055 433759 15205 22059 15213 12912 76580 15185 232232 70315 56198 15214 15184 264064 14939 20185 20602 22190 21888 239528 21885 667035 21886 81004 19346 213988 14534 16396 15183 51813 270118 217351 208117 54613 233833 214150 19165 100039623 100042305 100042343 20443 17454 FBXW7 MUTANTS AND NOTCH1 IN CANCER%REACTOME DATABASE ID RELEASE 57%2644605 FBXW7 Mutants and NOTCH1 in Cancer 21402 26965 56438 18128 ACTIVATION OF GABAB RECEPTORS%REACTOME DATABASE ID RELEASE 57%991365 Activation of GABAB receptors 16524 16515 224129 16522 16513 11513 11512 16520 11515 11514 104110 16518 16521 14706 16516 14678 14677 14679 14688 14708 14693 14709 14699 14700 14701 210044 432530 14695 104111 16517 14704 242425 14702 14710 16519 54393 242851 14680 RNA POLYMERASE I PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 57%73854 RNA Polymerase I Promoter Clearance 18519 17749 66420 245841 319181 107932 66467 234366 232440 216848 106298 14884 23942 382522 319176 319955 433759 15182 12572 26417 17420 624153 69833 625328 51788 15077 319149 17191 100043714 245688 229542 66136 116870 21341 21340 15267 20017 319183 110147 21374 70333 19646 667501 22130 319182 319178 319186 319190 21429 75316 64424 20016 14534 20018 20019 319168 21339 66671 319167 23894 17192 13871 13872 116871 209357 14885 319188 15270 319169 78303 SOS-MEDIATED SIGNALLING%REACTOME%R-HSA-112412.1 SOS-mediated signalling 56438 26395 67603 319520 235584 26403 16416 12223 54519 100042150 21894 11600 19060 19186 19188 327826 17169 194231 109905 14161 226525 57296 67151 215449 19185 66998 53380 14172 17967 15461 17463 83409 69077 29875 26417 26413 12323 108058 12322 18015 59029 19197 19417 19184 19179 22190 20422 171463 14573 667035 19182 16590 240057 19181 231474 64654 80903 14173 23997 14164 66997 18039 218397 110135 14585 14178 80857 228769 14180 70247 67089 14586 14587 14175 21762 14177 23996 20416 11876 14165 26554 18596 109880 16399 54153 15200 640703 18673 12325 16706 69601 83379 22371 73902 233046 114716 12981 19415 63953 14174 12982 19252 16653 12984 240672 13537 12988 67836 16186 13385 14588 211323 16184 11836 18188 20740 20739 13645 16185 16452 216869 109689 18176 72399 70686 114715 240168 14268 66413 211255 18183 14083 16451 19192 16453 26445 19166 18218 14812 76089 26444 26446 14811 26443 14813 19414 80297 14814 16183 20742 20741 21687 20743 16367 13866 14810 16192 26396 14360 16191 216148 114713 14186 19418 22123 20662 19052 14170 19053 19262 73699 640524 16913 75590 19175 19177 51792 19713 19170 22330 99571 13874 103554 16912 54401 83961 16188 19173 19172 21770 26932 107971 226849 100986 18611 23980 26931 20418 225849 320484 384783 245684 67112 110157 19167 26441 19419 11472 19171 545987 13649 70727 18595 26442 26440 101809 18591 HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%R-HSA-629594.1 Highly calcium permeable postsynaptic nicotinic acetylcholine receptors 11438 231252 110834 110902 108015 11435 11444 110835 11440 108043 11441 INTERLEUKIN-6 FAMILY SIGNALING%REACTOME DATABASE ID RELEASE 57%6783589 Interleukin-6 family signaling 19247 12931 16452 12402 13019 16156 16880 20848 246779 16451 12702 12804 50498 12803 16195 16194 16193 16162 18413 54721 50931 56708 18414 16878 16159 100042555 DISEASES ASSOCIATED WITH O-GLYCOSYLATION OF PROTEINS%REACTOME DATABASE ID RELEASE 57%3906995 Diseases associated with O-glycosylation of proteins 269328 100039649 108153 13138 77739 240322 20357 21826 21825 140474 20356 207596 17829 100689 233744 224116 353328 224697 271127 108154 208936 73732 235130 237360 269959 239337 243369 279028 77794 210417 223838 56229 18131 330119 17063 240913 216725 18129 229595 18636 18128 226866 66548 11504 30806 18132 330267 23794 BASIGIN INTERACTIONS%REACTOME%R-HSA-210991.1 Basigin interactions 268373 20737 11931 66053 53896 83995 12389 26570 16400 50934 30962 16403 16728 17136 80879 57274 330836 20501 20540 17254 12215 11932 16412 20539 11933 FORMATION OF INCISION COMPLEX IN GG-NER%REACTOME DATABASE ID RELEASE 57%5696395 Formation of Incision Complex in GG-NER 72584 99375 22190 13194 667035 19891 93836 66467 68240 70620 100043429 93765 14884 22591 26370 66671 20610 229615 22196 11545 22592 50505 13870 23894 68058 11546 19358 12572 22590 19359 17420 13871 13872 107986 209357 14885 77593 56469 56438 68275 PHOSPHOLIPID METABOLISM%REACTOME%R-HSA-1483257.1 Phospholipid metabolism 26971 18784 14792 78390 218121 23945 11842 14245 54384 11840 18779 225845 241274 18782 56209 66350 66569 329502 50767 18778 271844 99010 16331 233552 26970 26565 16332 74769 18807 18707 18709 53357 12038 11423 12647 224020 64436 320981 103199 234129 68616 107650 234729 83493 18711 242259 68682 70129 100434 213603 67512 55979 77116 14732 231510 14555 333433 18710 210992 28169 215456 75320 28042 12651 102278 13026 18618 19210 18783 212862 66586 71760 12660 66853 67800 99712 66857 270084 236899 116939 105501 13350 237928 225010 232889 67452 102247 668257 320951 14712 231086 66826 68262 97212 106861 665270 52123 218865 17772 104709 97287 170749 12891 77582 226856 52858 66727 75669 104759 117150 266692 225326 18805 110911 27281 19062 18806 27388 30955 101490 64898 70568 84095 68671 20975 114874 269180 245532 18705 18717 74451 104015 74596 18704 74182 74302 110695 219135 66461 240752 192166 67073 67216 320207 237625 53332 74129 234515 12116 320634 18708 56305 18706 18720 18719 108083 64899 19211 18718 TGFBR1 LBD MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 57%3656535 TGFBR1 LBD Mutants in Cancer 14225 21803 21813 21812 ORGANIC CATION TRANSPORT%REACTOME%R-HSA-549127.1 Organic cation transport 20517 70840 18400 20519 30805 20518 20520 242126 RHO GTPASES ACTIVATE KTN1%REACTOME DATABASE ID RELEASE 57%5625970 RHO GTPases activate KTN1 16709 16572 56212 19353 16573 11848 74764 16594 16593 232943 MITOCHONDRIAL BIOGENESIS%REACTOME DATABASE ID RELEASE 57%1592230 Mitochondrial biogenesis 56406 11909 12914 226153 17260 217166 20185 15278 109151 81004 11655 216151 26379 19017 108099 17261 29857 19079 108097 19094 19082 50776 229003 19013 21372 19014 15183 108079 241113 26416 208595 66993 170826 670717 12912 18181 59035 21780 14390 17978 11947 226169 224481 64384 20181 381760 15161 17977 INTERLEUKIN-19, 20, 22, 24%REACTOME DATABASE ID RELEASE 57%8854691 Interleukin-19, 20, 22, 24 116849 16155 213208 230828 237310 237313 329244 58181 93672 FREE FATTY ACID RECEPTORS%REACTOME DATABASE ID RELEASE 57%444209 Free fatty acid receptors 233080 233079 107221 436440 233081 DECTIN-1 MEDIATED NONCANONICAL NF-KB SIGNALING%REACTOME DATABASE ID RELEASE 57%5607761 Dectin-1 mediated noncanonical NF-kB signaling 53859 19186 19188 57296 67151 66413 19185 66998 53380 19192 26445 17463 19166 69077 26444 12234 26446 26965 26443 22192 22123 22200 59029 19184 19179 22190 20422 667035 19182 19181 23997 66997 21402 16913 228769 70247 19175 67089 19177 103583 19170 21762 23996 103554 16912 19173 19172 12675 19697 73902 19167 26441 19698 18034 19171 26442 26440 ADRENOCEPTORS%REACTOME%R-HSA-390696.1 Adrenoceptors 11555 11548 11549 11550 11551 11552 11554 11556 11553 TP53 REGULATES TRANSCRIPTION OF SEVERAL ADDITIONAL CELL DEATH GENES WHOSE SPECIFIC ROLES IN P53-DEPENDENT APOPTOSIS REMAIN UNCERTAIN%REACTOME DATABASE ID RELEASE 57%6803205 TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain 11799 22062 21981 64058 19352 22059 56187 66813 12053 12662 17988 209456 22061 SEROTONIN AND MELATONIN BIOSYNTHESIS%REACTOME%R-HSA-209931.1 Serotonin and melatonin biosynthesis 21990 11298 13195 216343 TOXICITY OF TETANUS TOXIN (TENT)%REACTOME DATABASE ID RELEASE 57%5250982 Toxicity of tetanus toxin (TeNT) 22318 N-GLYCAN TRIMMING AND ELONGATION IN THE CIS-GOLGI%REACTOME DATABASE ID RELEASE 57%964739 N-glycan trimming and elongation in the cis-Golgi 17156 242362 230815 17155 17308 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS.%REACTOME%R-HSA-163200.1 Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. 66706 229211 670717 12868 68202 17992 17710 66152 17711 17709 68472 75406 70207 69702 22272 20463 70316 231430 52892 76916 100040287 17708 67273 69487 66495 76826 12861 17991 22273 12857 17722 54405 100042918 66091 110323 104130 68198 66841 66694 110826 110842 20930 73694 230075 76947 67003 100041785 67530 68493 17719 26940 66142 66379 12858 17718 72416 17717 17716 239760 66359 225887 66108 17721 66416 68375 66916 67130 78330 75597 67184 66414 623286 66218 67264 68342 100042503 226646 595136 72900 227197 68197 66377 66046 17995 17993 624814 66272 66445 69802 74011 22227 20523 22228 22229 57423 11957 11946 66945 11947 432676 228033 17705 66052 66043 68055 11949 100039108 227112 100041835 11950 11958 66925 67680 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION%REACTOME DATABASE ID RELEASE 57%983169 Class I MHC mediated antigen processing & presentation 66313 22210 75788 53323 30839 77371 213980 12010 30838 30050 216150 21356 14991 20619 21355 22320 242960 20909 50754 50789 240095 21354 15007 22319 22192 13040 56438 106052 50762 70093 67615 235320 100041484 224826 66743 67921 19820 13057 215061 67455 140499 56371 232539 17874 94090 12491 57751 78913 13058 66772 17970 12229 65257 17972 230903 17969 17237 17533 672511 246278 30945 17534 70928 93765 101358 12703 67345 103583 21898 217217 104184 67731 77113 68431 231863 70294 76375 59009 14794 18744 16924 212919 242785 21899 17087 66589 24088 21897 320118 66156 70392 78541 211007 240028 142688 14828 69299 52206 72194 668450 76454 67845 242521 22194 67128 19186 269514 19188 22222 70620 627648 207215 100041766 216080 66799 22019 15204 231670 57296 22193 67151 66105 328234 56736 12449 19185 74153 100763 67588 66998 50788 53380 399566 76294 208372 117589 17463 68854 69077 72323 211949 74132 12475 59044 94091 14827 117149 235439 12234 268470 140630 217342 209239 230654 76580 19823 224170 52563 218215 99152 54484 233040 214931 79263 209200 69010 78889 71393 56515 244421 69957 67138 99683 233902 12317 74492 68999 69706 68612 227738 56228 448987 17222 22200 70348 218793 56791 59029 83962 217194 329152 19184 224619 19179 22190 207304 13039 20422 224023 20821 667035 93836 209462 19182 69754 15006 321006 50760 19181 100039535 224938 228003 109161 23997 68497 66997 22201 81018 22195 667803 22209 69116 330369 228769 65255 70247 65247 67089 380928 22036 74646 21762 226098 23996 140629 75234 231672 243574 26554 19155 433766 76608 117146 208650 213311 30843 78910 142687 28105 59008 56317 67490 65256 226541 231380 73902 19822 230904 80898 635668 68628 107995 68729 269529 71999 217232 22213 69807 71538 22214 22215 240396 98766 23807 207952 83814 66413 211255 19192 24105 26445 12702 19166 84585 20333 26444 80751 26446 26965 26443 218203 27401 50868 22123 66663 170737 71865 14897 268291 59026 636931 73998 66515 69608 21402 66397 16913 19175 19177 19170 103554 22346 16912 71745 19173 19172 12675 19167 16151 26441 16150 19171 67923 26442 26440 75717 20334 20437 218811 68098 57743 17999 66212 69162 50873 53421 100043039 107568 110379 56424 14129 12330 16396 20439 16419 74244 16410 GLOBAL GENOME NUCLEOTIDE EXCISION REPAIR (GG-NER)%REACTOME DATABASE ID RELEASE 57%5696399 Global Genome Nucleotide Excision Repair (GG-NER) 72584 18973 19687 235134 69263 67967 19718 99375 18972 108679 13194 18538 19891 69745 66467 70620 68240 56249 18971 109275 26891 14884 26370 68142 20610 100043806 27015 11545 16881 22632 11546 19358 12572 19359 17420 12848 107986 59001 72151 106344 56456 66979 18974 56438 68275 70020 26895 22594 22190 11461 69714 56505 93836 667035 16882 227195 233875 26754 100043429 26893 93765 22591 66671 229615 26894 22196 225280 22592 50505 13870 23894 68058 22590 13871 13872 209357 77593 14885 56469 26572 FCERI MEDIATED MAPK ACTIVATION%REACTOME%R-HSA-2871796.1 FCERI mediated MAPK activation 16822 17096 57257 17444 22325 56438 224105 26420 16476 19353 26414 26395 26401 26398 67603 319520 26419 14281 235584 26403 16416 12223 54519 100042150 21894 11600 19060 19186 19188 327826 17169 194231 109905 14161 226525 57296 67151 215449 19185 66998 53380 14172 17967 15461 17463 83409 69077 29875 26400 26417 26413 12323 108058 12322 18015 59029 19197 19417 19184 19179 22190 20422 171463 14573 667035 19182 16590 240057 19181 231474 64654 80903 14173 23997 14164 66997 18039 218397 110135 14585 14178 80857 228769 14180 70247 67089 14586 14587 14175 21762 14177 23996 20416 11876 14165 26554 18596 109880 16399 54153 15200 640703 18673 12325 16706 69601 83379 22371 73902 233046 114716 12981 19415 63953 14174 12982 19252 16653 12984 240672 13537 12988 67836 16186 13385 14588 211323 16184 11836 20963 18188 20740 20739 13645 16185 16452 216869 109689 18176 72399 70686 114715 240168 14268 66413 211255 18183 14083 16451 19192 16453 26445 19166 18218 14812 76089 26444 26446 14811 26443 14813 19414 80297 14814 16183 20742 20741 21687 20743 16367 13866 14810 16192 26396 14360 16191 216148 114713 14186 19418 22123 20662 19052 14170 19053 19262 73699 640524 16913 75590 19175 19177 51792 19713 19170 22330 99571 13874 103554 16912 54401 83961 16188 19173 19172 21770 26932 107971 226849 100986 18611 23980 20418 26931 320484 225849 384783 245684 67112 110157 19167 26441 19419 11472 19171 545987 13649 70727 18595 26442 26440 101809 18591 18803 234779 18479 22324 PHOSPHORYLATION OF PROTEINS INVOLVED IN THE G2 M TRANSITION BY CYCLIN A:CDC2 COMPLEXES%REACTOME%R-HSA-170145.1 Phosphorylation of proteins involved in the G2 M transition by Cyclin A:Cdc2 complexes 12534 12427 12428 TRANSPORT OF GAMMA-CARBOXYLATED PROTEIN PRECURSORS FROM THE ENDOPLASMIC RETICULUM TO THE GOLGI APPARATUS%REACTOME DATABASE ID RELEASE 57%159763 Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus 14456 14068 14058 14071 14061 66901 19128 19123 TELOMERE C-STRAND SYNTHESIS INITIATION%REACTOME DATABASE ID RELEASE 57%174430 Telomere C-strand synthesis initiation 59001 18973 66979 18974 18969 19075 18968 19076 AFLATOXIN ACTIVATION AND DETOXIFICATION%REACTOME DATABASE ID RELEASE 57%5423646 Aflatoxin activation and detoxification 110198 207182 13087 23887 109652 66447 71670 13114 71522 71854 13479 13077 319446 14598 211666 56615 SALM PROTEIN INTERACTIONS AT THE SYNAPSES%REACTOME DATABASE ID RELEASE 57%8849932 SALM protein interactions at the synapses 13385 14812 53623 14811 70530 14813 14252 53310 233067 14814 225875 14810 19268 13383 14799 20168 14251 14802 19280 ACTIVATION OF NIMA KINASES NEK9, NEK6, NEK7%REACTOME DATABASE ID RELEASE 57%2980767 Activation of NIMA Kinases NEK9, NEK6, NEK7 12534 217718 59125 12442 18817 59126 SYNTHESIS OF DIPHTHAMIDE-EEF2%REACTOME DATABASE ID RELEASE 57%5358493 Synthesis of diphthamide-EEF2 66632 13629 105638 116905 67228 67728 69740 99349 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL%REACTOME DATABASE ID RELEASE 57%112314 Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell 13385 11447 11449 11771 14706 14696 14678 14677 14679 14688 14708 14693 14709 14697 14812 14811 14813 16517 14814 242425 14809 16519 18693 14395 74053 67071 54393 14394 14810 242851 21912 11438 14397 110834 14807 14399 108015 14802 11444 54376 110886 52589 19418 14800 12300 11448 14396 55984 14401 53623 14402 16524 14408 14407 16515 16522 81905 16513 14400 243547 16520 236915 14805 14806 14406 54377 16518 16521 328699 16516 110637 14409 20130 13383 231252 110902 11435 238276 110835 11440 108043 11441 14699 66066 14700 14701 14695 100986 53310 14704 14702 14710 64337 110157 11472 14680 18750 18796 18795 18752 104110 18751 18797 15461 110651 18195 20111 12912 26413 20112 14799 12323 108058 12322 224129 19417 11513 11512 57249 11515 11514 12326 18039 18747 18749 210044 432530 109880 17920 104111 640703 17246 12325 18607 BETA OXIDATION OF DECANOYL-COA TO OCTANOYL-COA-COA%REACTOME DATABASE ID RELEASE 57%77346 Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA 15107 93747 11364 231086 97212 CLASS C 3 (METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS)%REACTOME DATABASE ID RELEASE 57%420499 Class C 3 (Metabotropic glutamate pheromone receptors) 353165 12374 14816 387512 14823 108071 57253 387347 574417 210198 387355 387356 110326 83770 387513 242425 387349 57254 387342 108073 108069 353148 387353 54393 387616 387515 387348 108068 83771 268934 GPCR DOWNSTREAM SIGNALING%REACTOME%R-HSA-388396.2 GPCR downstream signaling 258659 258640 258292 259147 258163 258443 258656 257898 258381 257917 258371 404346 258222 258296 258616 258704 258151 258405 258563 18313 258470 258672 258153 258690 18314 18312 258821 258373 257884 258358 258937 258702 258763 258179 258703 258271 259049 259066 258025 258857 258439 258836 668035 258075 259089 259012 18369 259095 258657 259092 258542 258769 16952 258729 258347 258935 258321 259071 258487 258486 258939 258609 258268 258908 258749 259097 258318 258985 56858 258420 258776 57251 258515 259035 258531 258352 257972 258507 259063 258814 258946 258305 258759 258407 258804 258287 259074 258975 258275 404331 258506 258775 258338 258544 258387 258772 258354 259051 57271 259002 100043474 258424 259100 258147 258469 258455 258206 100038859 259058 258746 258481 259045 258355 257883 258325 258536 56015 259019 258562 258881 258713 258098 258302 258756 14682 258478 14675 259036 21390 259034 14676 258614 14672 258319 14674 258914 258710 258238 258694 258700 404315 259119 259075 258819 257905 258720 259047 258717 18366 404318 18367 436002 258154 20607 258600 258160 207911 258036 18341 258427 18330 258350 258178 404222 23945 12000 11848 22094 26361 54140 14308 207728 23984 243764 241489 54611 18576 11540 11539 11541 11542 14816 140795 67168 78826 108071 14678 14677 14679 70839 74191 57385 233571 235036 18441 18442 78134 574402 57257 22325 12640 242851 16866 233081 19353 225642 11607 11998 320129 21336 104709 30955 320207 16443 15466 99296 15465 225192 14685 14686 14687 258322 18328 258866 258270 258990 18322 259053 258586 258869 259041 258248 258357 259110 259109 258580 258582 258587 259112 258362 258363 258575 258853 258601 258650 80706 259106 258675 259014 259054 404317 258636 259115 18365 258805 258961 258736 258882 258097 259015 258991 258944 258992 258941 258299 258618 242425 258216 228228 244187 258572 259004 667918 257916 258697 258752 54393 258925 258896 259122 258924 170639 668825 259113 259017 258155 258680 258303 258620 29849 258933 258606 18317 257962 258310 258395 258334 258196 18357 258715 18315 18346 258267 258922 258207 258316 546747 18343 258408 257909 258432 258832 258608 259067 18310 259040 329460 258794 258281 404329 258677 258846 117004 258016 258027 404319 545140 258930 258658 258831 218066 259013 258105 259111 258453 258706 258573 18331 257985 258340 258854 258673 258039 258980 258458 14680 18324 18796 18795 15563 18751 15562 15560 15550 15566 15565 15552 15551 18798 15559 18797 15558 15557 15874 19878 56212 19354 11852 11853 19739 12772 20287 11517 14706 24012 14607 14696 14526 224014 14527 269608 11516 14602 101497 14688 13605 12458 14708 14693 75547 14709 26382 16800 14601 16801 14697 19216 19218 14764 19220 11820 14699 66066 14700 14701 14695 93896 18755 14652 14704 14702 331374 381853 56077 14710 14065 64337 66082 320127 380921 110524 104418 13139 14062 14673 110197 76192 231871 269060 11552 14064 217480 12273 15139 12266 12267 18710 19395 21338 20210 21333 21334 21337 57349 56744 385643 20416 19204 18761 50779 12981 50782 12982 12984 16186 16184 16185 16452 216869 109689 545156 19219 16451 16453 74769 16183 18707 18709 16192 16191 19418 18167 76854 12767 58175 18168 12854 56838 227288 240816 12765 236915 14739 217212 381810 227326 330122 14823 624910 20662 22065 67839 19065 12774 19064 18619 100038965 16188 20606 100039973 110312 51791 22068 387513 65086 17329 387349 57254 387342 626596 12145 108073 108069 84112 19736 19419 14825 235611 387616 50778 12775 12776 20310 12778 12768 67792 12771 12773 18750 18753 18754 54126 213788 26946 18752 104110 17200 104443 230777 229214 14539 237362 12057 13603 15171 353344 30044 20132 57811 51801 223780 11535 54615 12311 12310 227717 56089 387285 54409 13489 11548 11549 12671 11550 12669 12672 13490 13491 14773 16867 18573 381413 19877 319239 19214 80910 224129 14309 238725 11513 212108 11512 100043254 22353 11515 17202 11514 17199 17201 17203 26385 22095 209512 71223 215855 114640 11652 218461 22354 16336 11651 243270 80885 16440 93690 71704 382348 110355 213498 102098 18574 277360 16438 110385 226970 18577 207212 13492 20663 210044 19228 73341 213527 432530 238871 56349 19773 23797 12922 104111 14608 18583 18584 171207 18578 24001 13488 239530 223435 215854 109904 29863 12918 14761 227289 18607 19226 111174 12921 22324 109934 22355 69632 19217 19227 383563 30938 381489 21844 503558 17207 19222 230972 11554 213649 11556 53972 16439 140498 14163 58182 246313 23832 319197 233079 18217 22045 217369 246691 22044 14744 233080 280287 208188 56696 14063 12424 12209 12425 13618 11555 24111 18101 68039 14715 114229 67405 16963 13615 13614 58861 57260 14714 238377 50501 13616 13617 14829 54598 210198 18429 18430 64214 381073 71729 353165 17773 244701 23919 15199 56066 239336 109648 12374 20315 11609 387512 15945 18386 94226 20609 14427 57253 18389 14429 14428 14293 387347 20608 55985 574417 208990 14289 14294 110168 20297 18166 14419 387355 18155 20304 30878 387356 20604 216749 56470 14745 242093 13610 12801 13609 67865 353148 19737 12802 387353 66102 12769 387515 13611 387348 19734 108068 53978 246709 268934 18216 12426 224065 16995 70086 239283 226304 12766 12062 18387 80901 14389 14767 12777 18708 56183 12061 18706 20605 433292 20311 20300 23796 14061 18610 18390 11606 11551 11553 212541 52666 14459 18976 19735 50780 56533 AMINE-DERIVED HORMONES%REACTOME DATABASE ID RELEASE 57%209776 Amine-derived hormones 13166 13195 70337 22094 99439 18948 21823 21990 11298 22018 13370 13371 214593 12640 216343 114479 107585 DISEASES OF SIGNAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 57%5663202 Diseases of signal transduction 14370 18519 14368 13363 207742 14367 66753 20423 242864 16147 12402 59287 54485 13388 16450 16449 433586 15519 56438 21416 14366 19771 20897 21372 17127 19664 12223 100042150 19186 19188 327826 269523 57296 22416 67151 18710 19185 66998 53380 14172 15461 17463 69077 16974 79221 170787 225164 208727 15208 240055 433759 15205 15213 12912 76580 15185 74493 232232 70315 56198 15214 264064 15184 68092 433702 59029 20185 20602 19184 19179 22190 20422 667035 19182 16590 19181 64654 14173 80903 14164 23997 67529 66997 20848 14178 80857 228769 14180 70247 432508 67089 20846 13047 14175 21762 14177 23996 20416 21848 67384 14165 20851 360013 21951 18596 20850 14389 76007 18708 15200 18706 16818 75296 110279 14182 83379 244373 73902 14174 16653 211323 13645 18176 66413 18183 19192 26445 19166 12576 26444 26446 26965 26443 15182 12575 74769 18707 18709 16367 13866 14360 14186 22123 12914 328572 18011 20662 19052 14170 19053 73699 21402 74126 16913 21803 19175 21813 19177 51792 21812 17869 19170 13874 103554 16912 11789 83961 56637 17128 93687 19173 72345 19172 17126 21770 26932 226849 12387 12005 26931 225849 384783 12675 67112 19167 26441 19171 234130 84035 13380 13649 73016 18595 16973 26442 56811 18128 26440 18591 11487 67710 17749 56233 66420 11491 245841 19247 15370 333639 20021 53627 69241 12519 13016 12524 12539 13017 14539 12057 20338 103806 14184 14183 116891 216440 606496 69833 68705 20022 69920 231329 98053 100043714 20020 19659 12015 56717 22084 77647 14225 19662 12371 81004 18803 56458 56484 14534 11652 12478 11651 78757 12487 15183 51813 270118 22139 208117 23797 67605 17246 56716 19165 18607 100039623 14388 100042305 22324 227743 109270 58988 SHC1 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 57%180336 SHC1 events in EGFR signaling 56438 26395 67603 319520 235584 26403 16416 12223 54519 100042150 21894 11600 19060 19186 19188 327826 17169 194231 109905 14161 226525 57296 67151 215449 19185 66998 53380 14172 17967 15461 17463 83409 69077 29875 26417 26413 12323 108058 12322 18015 59029 19197 19417 19184 19179 22190 20422 171463 14573 667035 19182 16590 240057 19181 231474 64654 80903 14173 23997 14164 66997 18039 218397 110135 14585 14178 80857 228769 14180 70247 67089 14586 14587 14175 21762 14177 23996 20416 11876 14165 26554 18596 109880 16399 54153 15200 640703 18673 12325 16706 69601 83379 22371 73902 233046 114716 12981 19415 63953 14174 12982 19252 16653 12984 240672 13537 12988 67836 16186 13385 14588 211323 16184 11836 18188 20740 20739 13645 16185 16452 216869 109689 18176 72399 70686 114715 240168 14268 66413 211255 18183 14083 16451 19192 16453 26445 19166 18218 14812 76089 26444 26446 14811 26443 14813 19414 80297 14814 16183 20742 20741 21687 20743 16367 13866 14810 16192 26396 14360 16191 216148 114713 14186 19418 22123 20662 19052 14170 19053 19262 73699 640524 16913 75590 19175 19177 51792 19713 19170 22330 99571 13874 103554 16912 54401 83961 16188 19173 19172 21770 26932 107971 226849 100986 18611 23980 26931 20418 225849 320484 384783 245684 67112 110157 19167 26441 19419 11472 19171 545987 13649 70727 18595 26442 26440 101809 18591 REGULATION OF IFNG SIGNALING%REACTOME%R-HSA-877312.1 Regulation of IFNG signaling 15170 15979 56469 15978 15980 19247 16451 12703 16452 12702 19246 REGULATION OF IFNA SIGNALING%REACTOME DATABASE ID RELEASE 57%912694 Regulation of IFNA signaling 15170 230398 15975 15977 20847 19247 24110 54721 16451 12703 12702 19246 GABA A RECEPTOR ACTIVATION%REACTOME%R-HSA-977441.1 GABA A receptor activation 14401 14402 14407 14400 236915 57249 14406 14395 14394 14397 14399 110886 14396 RNA POLYMERASE II TRANSCRIBES SNRNA GENES%REACTOME%R-HSA-6807505.1 RNA polymerase II transcribes snRNA genes 225283 67710 101861 68776 17749 18987 66420 245841 20841 71177 75137 235459 20021 269344 69241 99730 108143 229906 83602 57432 71793 227644 75627 102209 77634 56698 12572 231571 69917 68092 69833 330959 68705 433702 20022 68510 93697 69920 231329 98053 100043714 20020 70885 107951 21374 12454 77065 70422 109019 70470 109077 20683 63856 72656 218333 83701 68153 74197 192657 69882 71957 226182 18130 229543 13716 210925 21343 72949 18986 12455 CONDENSATION OF PROPHASE CHROMOSOMES%REACTOME DATABASE ID RELEASE 57%2299718 Condensation of Prophase Chromosomes 78658 15267 319183 14211 319181 18817 319182 319178 319186 67956 319190 232440 70099 671392 319168 382522 319167 52683 319176 319152 19645 624153 12534 625328 51788 15077 244329 319188 15270 319149 76044 78303 319169 G ALPHA (Q) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 57%416476 G alpha (q) signalling events 58182 246313 23832 319197 233079 23945 18217 22045 217369 246691 14816 22044 14744 233080 545156 67168 14706 78826 108071 14696 14526 14527 280287 14688 208188 14708 233571 56696 14693 14061 235036 14063 18441 14709 12424 18442 12209 78134 12425 574402 14697 13618 24111 18101 68039 14715 114229 67405 16963 13615 13614 58861 57260 18709 14714 238377 50501 13616 13617 233081 14829 240816 381810 225642 624910 19216 26361 19220 54140 11820 22065 14699 210198 66066 14700 14701 110312 14695 22068 18755 65086 14704 331374 14702 56077 14065 14710 66082 64337 320127 18429 380921 18430 110524 104418 19419 13139 14062 110197 76192 231871 269060 14064 217480 18796 64214 18795 18753 18754 213788 26946 12374 104443 230777 229214 237362 11607 15560 15171 18710 30044 16952 19395 15559 21338 18798 15558 18797 11606 54615 14289 227717 387285 20210 21333 21334 21337 216749 56470 11998 14745 11548 11549 12671 11550 12669 21336 385643 53978 14773 319239 100043254 52666 18216 12426 16440 14459 224065 16995 110355 70086 16438 14682 14675 15465 21390 12062 19735 14676 50780 14672 19204 14767 18708 56183 18761 12061 18706 433292 223435 207911 16439 CAMK IV-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%R-HSA-111932.2 CaMK IV-mediated phosphorylation of CREB 12326 12912 640703 METHYLATION%REACTOME%R-HSA-156581.4 Methylation 108645 14873 238505 210009 269378 18113 67674 11720 12846 13077 22017 57344 232087 67768 THE AIM2 INFLAMMASOME%REACTOME DATABASE ID RELEASE 57%844615 The AIM2 inflammasome 66824 383619 12362 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE%REACTOME%R-HSA-442720.1 CREB phosphorylation through the activation of Adenylate Cyclase 18749 432530 104111 12912 11514 18747 TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G1 CELL CYCLE ARREST%REACTOME DATABASE ID RELEASE 57%6804116 TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest 12576 59092 12448 22059 12575 12427 13555 12566 52679 13496 12447 29813 12428 G ALPHA (Z) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 57%418597 G alpha (z) signalling events 18750 58175 18753 224129 18754 11513 240816 11512 11515 11514 18752 104110 18751 14706 14696 14678 14677 14679 14688 14708 14693 14709 14697 14699 66066 14700 14701 210044 432530 14695 104111 18761 18755 14704 56470 14702 11551 14710 56533 64337 11553 19736 242851 11552 14687 RHO GTPASES ACTIVATE NADPH OXIDASES%REACTOME%R-HSA-5668599.2 RHO GTPases Activate NADPH Oxidases 71893 19353 224480 13057 237038 75669 225326 13058 17970 17972 17969 19354 241275 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME DATABASE ID RELEASE 57%186712 Regulation of beta-cell development 16334 18609 18096 19213 15379 11925 56458 103988 11652 20526 18088 11651 53626 15377 378435 246086 18506 21410 18012 21405 15376 15874 14165 30942 15205 23797 19664 18508 18128 GAP JUNCTION TRAFFICKING AND REGULATION%REACTOME%R-HSA-157858.1 Gap junction trafficking and regulation 14620 14617 14622 14616 14618 14619 14613 14611 67300 13429 225152 21872 14621 14612 353155 14615 74325 17920 12757 13132 14610 11773 13430 14609 118454 14623 INSULIN RECEPTOR RECYCLING%REACTOME DATABASE ID RELEASE 57%77387 Insulin receptor recycling 16334 66290 16337 21871 108664 27060 73834 140494 100039636 11974 242341 114143 11966 11975 68775 11972 66237 54411 11973 11964 110935 66144 338375 66335 76252 74915 RESPONSE OF MTB TO PHAGOCYTOSIS%REACTOME%R-HSA-1222499.1 Response of Mtb to phagocytosis 17002 ATF6-ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 57%381033 ATF6-alpha activates chaperones 56453 14828 18045 270669 18046 12317 226641 22027 11911 13198 18044 C6 DEAMINATION OF ADENOSINE%REACTOME DATABASE ID RELEASE 57%75102 C6 deamination of adenosine 110532 56417 ACYL CHAIN REMODELLING OF PE%REACTOME%R-HSA-1482839.2 Acyl chain remodelling of PE 26971 18784 14792 78390 218121 66727 27281 18779 225845 18782 66350 329502 18778 271844 67216 99010 237625 26970 26565 18783 66857 105501 53357 232889 67452 CA ACTIVATED K+ CHANNELS%REACTOME%R-HSA-1296052.1 Ca activated K+ channels 58802 16531 84036 140492 140493 72413 435726 16534 16533 SIGNALING BY NGF%REACTOME DATABASE ID RELEASE 57%166520 Signaling by NGF 11517 59287 192662 18759 224014 11516 269608 20598 101497 13605 94275 75547 26382 16800 16801 67733 13430 103967 56438 17260 13712 26395 192656 17874 67603 100040260 319520 26419 102626 17258 73086 235584 16179 26403 16416 12223 54519 100042150 21894 11600 19060 19186 19188 327826 17169 194231 109905 14161 226525 57296 67151 215449 18710 19185 66998 53380 14172 17967 15461 17463 83409 69077 29875 110651 17164 433759 72349 20111 12912 26417 26413 23939 20112 12323 108058 12322 18015 59029 19197 19417 19184 19179 20422 171463 14573 19182 16590 240057 19181 231474 80903 23997 66997 18039 218397 110135 13429 14585 14178 228769 70247 67089 14586 14587 21762 23996 20416 11876 14165 26554 18596 109880 16399 54153 15200 640703 18673 12325 16818 16706 69601 83379 22371 73902 233046 114716 12981 19415 63953 14174 12982 19252 16653 12984 240672 13537 12988 67836 16186 13385 14588 211323 18550 16184 11836 18188 20740 11772 20739 13645 16185 18553 16452 216869 109689 18176 18049 72399 545156 11771 70686 18211 114715 18212 71770 240168 14268 66413 211255 18183 14083 16451 19192 16453 26445 19166 56044 18218 14812 76089 18552 26444 26446 14811 26443 14813 12757 19414 232910 80297 14814 74769 11773 16183 20742 18707 18709 20741 21687 20743 16367 13866 14810 16192 26396 14360 16191 216148 114713 14186 19418 22123 11848 236915 20662 14170 19262 67300 640524 16913 75590 19175 19177 19713 19170 22330 99571 13874 103554 16912 54401 83961 16188 19173 19172 107971 100986 18611 23980 20418 320484 384783 245684 67112 110157 19167 26441 19419 11472 19171 545987 13649 70727 18595 26442 26440 101809 18591 18750 19088 16334 76850 18753 18754 11491 236511 54126 19247 16337 75778 15370 18752 20404 104110 229709 12519 12524 23938 54152 606496 244650 18573 12015 56717 12367 22084 224129 77647 11513 11512 26415 239528 11515 11514 12371 98432 117150 18803 56458 56484 213988 12326 11652 18717 12478 12366 11651 15937 16440 78757 228775 12487 71704 110355 15183 18747 213498 18574 102098 277360 16438 226970 18749 207212 217351 20663 210044 73341 18575 208117 432530 56349 233833 17136 23797 18053 104111 12125 67605 68585 11540 18720 171207 17246 56716 24001 18719 235402 214150 223435 108083 109904 19165 19087 12070 19085 100039623 18607 72843 19084 100042305 14388 56321 22324 109934 69632 18377 19211 30938 21844 227743 17207 18718 230972 109270 213649 17454 53972 16439 14163 58988 57257 22325 19353 77480 22627 22190 667035 64654 14173 14164 22034 20848 80857 14180 14175 16443 14177 18708 18706 12576 15182 12575 19052 19053 73699 51792 26416 56637 21770 26932 226849 26931 225849 12675 19697 18033 18035 16150 29857 19094 12929 18412 19730 12928 19769 19762 64143 107746 VEGFR2 MEDIATED VASCULAR PERMEABILITY%REACTOME DATABASE ID RELEASE 57%5218920 VEGFR2 mediated vascular permeability 16480 56717 19353 12388 75778 12389 11652 11651 18479 78757 228775 12385 57257 23797 640703 18127 22325 56716 15519 18607 18481 12562 22324 227743 109270 224105 MOLECULES ASSOCIATED WITH ELASTIC FIBRES%REACTOME%R-HSA-2129379.1 Molecules associated with elastic fibres 216760 16416 16420 17150 21808 12154 16998 14115 100034361 58859 12159 12162 12156 320910 76293 216616 241226 268977 21803 14563 50530 108075 14114 21809 16997 23876 22370 16419 16412 16410 TRAFFICKING OF AMPA RECEPTORS%REACTOME%R-HSA-399719.1 Trafficking of AMPA receptors 12323 18750 13385 108058 53623 12322 81905 243547 18752 54377 18751 11771 13383 238276 18195 17920 17246 12325 18693 74053 14799 21912 14802 54376 14800 12300 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE%REACTOME%R-HSA-1660516.4 Synthesis of PIPs at the early endosome membrane 17772 103199 77116 170749 234729 18711 75669 225326 101490 84095 269180 18704 67073 234515 SEROTONIN NEUROTRANSMITTER RELEASE CYCLE%REACTOME%R-HSA-181429.1 Serotonin Neurotransmitter Release Cycle 12889 22318 327814 68507 20964 19339 214084 22249 233977 20907 27204 20614 20965 20979 O-LINKED GLYCOSYLATION OF MUCINS%REACTOME DATABASE ID RELEASE 57%913709 O-linked glycosylation of mucins 78754 100039649 171212 272411 140474 17829 56386 231727 56336 20448 97440 108760 14426 73732 231050 227327 654821 271786 17063 210004 59048 20447 20446 269328 108148 53625 14425 108105 207839 14423 232984 26887 14537 241391 72297 224116 353328 94192 212996 72077 16494 333424 71685 67909 233733 230145 20442 108150 20443 20440 20444 CLEAVAGE OF THE DAMAGED PURINE%REACTOME%R-HSA-110331.1 Cleavage of the damaged purine 70603 18294 268395 AXONAL GROWTH INHIBITION (RHOA ACTIVATION)%REACTOME%R-HSA-193634.1 Axonal growth inhibition (RHOA activation) 192662 17136 11848 18377 18053 68585 235402 16801 INWARDLY RECTIFYING K+ CHANNELS%REACTOME%R-HSA-1296065.1 Inwardly rectifying K+ channels 16524 16515 16522 16513 16520 16518 16521 14706 20928 16516 14688 14708 14693 56379 14709 14699 14700 14701 16523 16514 14695 16517 211480 14704 242425 14702 14710 16519 54393 20927 NUCLEAR IMPORT OF REV PROTEIN%REACTOME DATABASE ID RELEASE 57%180746 Nuclear import of Rev protein 218210 66679 18226 69912 227720 54563 223921 103468 16211 70699 72787 100088 269113 231042 234865 69736 19069 107939 170762 18148 59015 227699 18141 445007 108989 19386 19384 69482 71805 ACTIVATION OF MATRIX METALLOPROTEINASES%REACTOME DATABASE ID RELEASE 57%1592389 Activation of Matrix Metalloproteinases 72902 18550 16621 17385 13039 17390 12822 83995 17392 240047 17384 17391 17393 17394 17395 17229 21858 17386 21857 17228 23948 13038 17389 13035 17387 22072 18815 17388 66473 50701 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS%REACTOME DATABASE ID RELEASE 57%452723 Transcriptional regulation of pluripotent stem cells 13819 20674 67710 53417 17749 66420 245841 58198 20021 69241 14173 332221 99377 15221 83557 383491 18999 22773 100038891 18514 20848 16600 620395 17128 17126 13835 69833 20022 69920 231329 26423 100043714 20020 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS%REACTOME%R-HSA-2644606.1 Constitutive Signaling by NOTCH1 PEST Domain Mutants 18519 11487 56233 11491 333639 59287 54485 13388 16450 16449 433586 103806 79221 170787 225164 208727 15208 240055 433759 15205 26965 15213 15182 76580 15185 232232 70315 56198 15214 264064 15184 56438 12914 20185 328572 20602 22190 18011 667035 81004 14534 21402 21372 17869 15183 51813 270118 208117 19165 19664 100039623 100042305 18128 RHO GTPASES ACTIVATE CIT%REACTOME DATABASE ID RELEASE 57%5625900 RHO GTPases activate CIT 233406 13385 12576 11853 12704 19353 11848 71960 67938 17886 17880 381293 67268 77579 11852 17904 CD28 DEPENDENT VAV1 PATHWAY%REACTOME%R-HSA-389359.1 CD28 dependent Vav1 pathway 18481 19353 22324 18479 14360 12487 16818 12519 224105 12524 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS%REACTOME DATABASE ID RELEASE 57%2151201 Transcriptional activation of mitochondrial biogenesis 12914 56406 11909 226153 17260 20185 217166 15278 109151 81004 11655 216151 19017 26379 17261 50776 19013 229003 21372 19014 15183 208595 66993 170826 670717 12912 18181 14390 21780 59035 11947 17978 226169 224481 64384 20181 15161 381760 17977 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK%REACTOME%R-HSA-881907.1 Gastrin-CREB signalling pathway via PKC and MAPK 14706 14696 14526 14527 14688 14708 14693 14709 14697 56438 26395 67603 19216 319520 19220 11820 14699 66066 14700 14701 14695 18755 14704 14702 331374 56077 14710 14065 64337 66082 320127 380921 110524 104418 13139 14062 110197 76192 231871 269060 235584 14064 217480 26403 16416 12223 54519 100042150 21894 11600 19060 19186 19188 327826 17169 194231 109905 14161 226525 57296 67151 215449 18710 19185 66998 53380 16952 14172 19395 21338 17967 15461 17463 83409 69077 29875 110651 20210 21333 21334 21337 20111 12912 26417 26413 23939 20112 385643 12323 108058 12322 18015 59029 19197 19417 19184 19179 20422 171463 17392 14573 19182 16590 240057 19181 231474 80903 23997 66997 18039 218397 110135 14585 14178 228769 70247 67089 14586 14587 21762 23996 20416 14682 11876 14675 14165 21390 26554 14676 18596 14672 109880 19204 16399 54153 15200 18761 640703 18673 12325 16706 69601 83379 22371 73902 233046 114716 12981 19415 63953 14174 12982 19252 207911 16653 12984 240672 13537 12988 67836 16186 13385 14588 211323 16184 23945 11836 18188 20740 20739 13645 16185 16452 216869 109689 18176 72399 545156 70686 114715 240168 14268 66413 211255 18183 14083 16451 19192 16453 26445 19166 18218 14812 76089 26444 26446 14811 26443 14813 19414 80297 14814 16183 20742 18709 20741 21687 20743 16367 13866 14810 16192 26396 14360 16191 216148 114713 14186 19418 22123 240816 381810 624910 20662 14170 26361 19262 640524 54140 22065 16913 75590 19175 19177 19713 19170 22330 99571 13874 103554 16912 54401 83961 16188 19173 19172 110312 22068 107971 100986 65086 18611 23980 20418 320484 384783 245684 67112 110157 19167 26441 19419 11472 19171 545987 13649 70727 18595 26442 26440 101809 18591 18750 18753 18754 213788 26946 104443 230777 229214 237362 15171 30044 54615 227717 387285 11548 11549 12671 11550 12669 14773 319239 100043254 16440 110355 16438 223435 16439 58182 246313 23832 319197 233079 18217 22045 217369 246691 14816 22044 14744 233080 67168 78826 108071 280287 208188 233571 56696 235036 14063 18441 12424 18442 12209 78134 12425 574402 13618 24111 18101 68039 14715 114229 67405 16963 13615 13614 58861 57260 14714 238377 50501 13616 13617 233081 14829 225642 210198 18429 18430 64214 12374 11607 14289 216749 11998 56470 14745 21336 53978 22190 667035 64654 14173 14164 18216 80857 12426 14180 224065 16995 14175 70086 14177 15465 12062 14767 18708 56183 12061 18706 433292 14061 19052 19053 73699 51792 21770 26932 226849 26931 225849 18796 18795 15560 18798 15559 18797 15558 11606 52666 14459 19735 50780 ARL13B-MEDIATED CILIARY TRAFFICKING OF INPP5E%REACTOME%R-HSA-5624958.1 ARL13B-mediated ciliary trafficking of INPP5E 64436 68146 18582 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR)%REACTOME%R-HSA-1168372.2 Downstream signaling events of B Cell Receptor (BCR) 108723 211323 13645 18176 240168 66413 18183 12042 19192 26445 19166 12576 26444 26446 26443 26965 74769 12575 18707 18709 16367 13866 14360 14186 22123 19052 19053 14170 73699 21402 16913 19175 51792 19177 103583 19170 13874 103554 16912 56637 83961 19173 21770 19172 26932 226849 26931 225849 12675 384783 19697 18033 67112 18036 18035 19167 16151 26441 19419 16150 19171 13649 18595 26442 26440 18591 16334 12223 76850 100042150 236511 19247 16337 75778 15370 19186 19188 327826 12519 12524 18751 57296 67151 18710 19185 66998 53380 14172 15461 17463 69077 12234 12912 26417 26413 606496 18037 19696 244650 12015 56717 59029 22084 77647 19184 19179 22190 20422 239528 26409 667035 19182 12371 16590 98432 117150 19181 64654 56458 80903 14173 56484 23997 14164 213988 66997 11652 18717 12478 11651 14178 240354 15937 228769 80857 70247 14180 78757 67089 228775 12487 21762 14175 23996 14177 217351 14165 18596 233833 18708 23797 15200 18706 67605 18720 17246 16818 56716 18719 214150 83379 108083 73902 18607 14388 22324 14174 19211 16653 227743 18718 109270 17454 58988 DEPURINATION%REACTOME DATABASE ID RELEASE 57%73927 Depurination 70603 18294 268395 VIF-MEDIATED DEGRADATION OF APOBEC3G%REACTOME%R-HSA-180585.1 Vif-mediated degradation of APOBEC3G 75717 19186 19188 57296 67151 66413 19185 66998 53380 19192 17463 26445 19166 69077 26444 26446 26443 56438 22123 59029 19184 22190 19179 20422 667035 19182 19181 23997 66997 16913 228769 19175 70247 67089 19177 19170 21762 23996 103554 16912 19173 19172 73902 19167 26441 19171 67923 26442 26440 LINOLEIC ACID (LA) METABOLISM%REACTOME DATABASE ID RELEASE 57%2046105 Linoleic acid (LA) metabolism 68801 54326 56473 11666 12686 76267 54325 14081 CHROMATIN MODIFYING ENZYMES%REACTOME DATABASE ID RELEASE 57%3247509 Chromatin modifying enzymes 13486 18519 72195 217031 77853 228829 74026 217127 77766 67773 230233 107932 75565 18505 228714 382207 76901 66233 269424 216848 76719 20587 71777 20588 208146 15353 140858 226976 214572 21427 83796 54351 66923 69612 68094 58523 83797 73247 223527 74195 56790 78656 83766 107435 23942 239985 27878 99890 13831 77044 28019 109115 72341 66423 67155 57376 93760 76804 99982 22289 225876 20591 18676 77035 338523 20592 71371 320595 214899 277250 244694 104263 107817 30841 11909 19646 73251 381022 234135 75410 52690 213389 66310 21372 54343 64707 69726 239122 18193 84505 214162 217864 235626 231051 213464 208043 233904 208266 23808 14013 70673 225895 56397 108946 217588 17692 21761 102162 216850 100041953 319181 50724 234366 268936 382522 170787 269003 433759 70315 94246 226830 246103 11569 56456 60406 100683 229542 319183 20185 20602 319182 193796 230674 319178 67956 319186 319190 78783 107823 319162 71954 81601 17192 59035 218214 319188 15270 78303 13626 66464 16452 66262 108155 108143 75560 64050 15182 216185 56310 75605 19712 70465 107392 238247 27374 245688 15161 116870 12914 328572 56505 70088 20174 12567 12443 20586 66993 12753 116871 319169 14056 621893 216825 232440 319189 93871 20937 101206 319176 77683 319173 17978 624153 15469 51788 15077 13435 319149 17977 52615 15267 110147 11461 81004 18599 18600 18602 18601 242726 14534 319163 319168 15183 319167 244349 TRANSCRIPTIONAL REGULATION BY SMALL RNAS%REACTOME DATABASE ID RELEASE 57%5578749 Transcriptional regulation by small RNAs 218210 66679 18226 67710 69912 17749 66420 236511 245841 319181 227720 54563 223921 103468 70699 20021 232440 69241 72787 269113 231042 234865 69736 19069 382522 107939 319176 170762 59015 624153 227699 320727 69833 625328 18141 51788 20022 15077 69920 445007 231329 108989 319149 19386 100043714 20020 69482 71805 15267 319183 239528 319182 319178 319186 319190 319168 319167 233833 319188 15270 78303 19384 319169 CATECHOLAMINE BIOSYNTHESIS%REACTOME%R-HSA-209905.1 Catecholamine biosynthesis 18948 21823 13166 13195 NECTIN NECL TRANS HETERODIMERIZATION%REACTOME DATABASE ID RELEASE 57%420597 Nectin Necl trans heterodimerization 19294 94332 58235 54725 58998 71740 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION%REACTOME%R-HSA-975138.1 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7 8 or 9 activation 19094 11596 110651 20210 12234 17164 72349 26965 20111 12912 26400 26417 240518 26413 23939 20112 257632 81897 266632 26420 170743 107607 11909 16476 170744 17260 13712 434174 22190 26414 108960 26395 26409 26401 667035 26398 26397 192656 17874 67603 19052 100040260 19053 319520 73699 26419 68652 11820 21402 66724 102626 22034 20203 66513 17258 93765 51792 26940 103583 26416 21770 12675 19697 18033 26399 18036 231130 18035 16151 18034 73086 16150 67245 93834 13211 66589 14281 26410 235584 16179 ACTIVATION OF RRNA EXPRESSION BY ERCC6 (CSB) AND EHMT2 (G9A)%REACTOME DATABASE ID RELEASE 57%427389 Activation of rRNA Expression by ERCC6 (CSB) and EHMT2 (G9a) 116870 15267 110147 319183 19646 12417 22130 107932 319181 319182 319178 319186 319190 234366 232440 216848 319168 23942 382522 319167 319176 319955 433759 15182 17192 116871 624153 625328 51788 15077 319188 319149 15270 78303 245688 319169 229542 HISTIDINE, LYSINE, PHENYLALANINE, TYROSINE, PROLINE AND TRYPTOPHAN CATABOLISM%REACTOME%R-HSA-6788656.1 Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism 14317 140483 30956 71761 18478 243537 270076 15109 212647 66514 266645 107239 229905 15186 98256 234724 70266 217593 209176 107766 15930 70789 56720 19125 23923 110695 71562 110391 13180 14085 72947 235386 14204 14874 18293 15233 15445 12971 19193 78920 13382 DEFECTIVE B3GALTL CAUSES PETERS-PLUS SYNDROME (PPS)%REACTOME%R-HSA-5083635.1 Defective B3GALTL causes Peters-plus syndrome (PpS) 108153 77739 240322 20357 21826 21825 207596 20356 100689 233744 224697 271127 108154 235130 208936 237360 269959 243369 239337 77794 279028 210417 223838 56229 330119 240913 229595 216725 18636 66548 226866 11504 30806 330267 23794 SYNTHESIS AND PROCESSING OF ENV AND VPU%REACTOME DATABASE ID RELEASE 57%171286 Synthesis and processing of ENV and VPU 18550 TIGHT JUNCTION INTERACTIONS%REACTOME DATABASE ID RELEASE 57%420029 Tight junction interactions 12737 56173 12738 71908 114141 54420 12740 53624 18759 56217 56863 12741 93742 75677 56492 12739 58187 242653 93737 12695 239931 18417 58220 224912 54419 56513 60363 16456 621628 64945 DOWNREGULATION OF ERBB4 SIGNALING%REACTOME%R-HSA-1253288.1 Downregulation of ERBB4 signaling 16396 17999 22190 667035 107568 ACTIVATION OF HOX GENES DURING DIFFERENTIATION%REACTOME DATABASE ID RELEASE 57%5619507 Activation of HOX genes during differentiation 14056 56406 67710 13626 17749 66420 245841 319181 20021 232440 69241 140858 382522 319176 13654 22632 17979 58184 22658 22289 624153 69833 625328 51788 20022 15077 69920 18508 231329 319149 104625 20181 100043714 245688 20020 15412 15400 52615 15401 12914 15267 13018 16476 16475 319183 17268 218772 19646 20185 15394 328572 17344 19401 67278 15399 319182 15436 19411 319178 15434 319186 55982 16658 319190 15429 18771 381022 18514 319168 15183 319167 231051 213464 23808 15423 319188 15270 319169 78303 15407 15410 103889 329559 CELLULAR RESPONSES TO STRESS%REACTOME DATABASE ID RELEASE 57%2262752 Cellular responses to stress 19891 68240 56455 15977 12017 110920 15519 67669 56354 22791 17165 66538 18415 70369 15526 50497 56438 213539 68275 73442 219158 72630 29810 15525 70356 23950 26420 12418 16476 19646 13057 26414 26398 26397 56371 13058 30951 26419 102626 12447 22627 64930 66096 26399 54170 15901 245670 68576 14281 68441 66508 52187 105787 13619 66156 17535 216850 14828 52206 668450 26921 26408 54383 319181 665113 50932 22194 494448 75430 100041766 216080 269523 66105 11920 52717 667310 83409 382522 110651 12448 19821 17164 22059 20111 15185 26400 26417 52563 99152 26413 23939 20112 497652 21749 28113 12566 101185 57321 69957 68999 68612 17222 12323 22166 108058 12322 97287 319183 22190 21750 319182 319178 667035 319186 319190 12427 20848 74302 56208 67384 19360 319152 12325 12416 81601 59008 56317 27354 12151 217232 18477 319188 15270 78303 12428 13626 14778 56551 18453 20656 11927 20657 50490 11758 11757 67305 14780 75512 66401 26462 12460 69590 75608 14776 12579 75560 12576 14958 16193 66403 12578 15364 15361 170644 80838 670717 50708 12571 13557 93759 19645 12575 50709 13555 21781 15505 242705 245688 11863 13819 12914 230099 53417 328572 15251 22339 13856 17684 68953 52639 11833 100043858 12580 12567 20683 108079 241113 66700 22346 26416 71745 112406 56637 112407 19763 105513 19697 18033 208092 545987 66371 67923 319169 218210 14056 66679 18226 76850 69912 241915 236511 227720 54563 16175 223921 103468 70699 232440 72787 108099 19079 23872 108097 19094 23871 13875 19082 269113 231042 234865 69736 19069 107939 319176 77683 170762 68097 68196 193740 50527 15481 81489 12955 15482 66734 15512 100043508 14228 74370 67443 15499 59015 80888 227699 624153 18141 625328 51788 15077 445007 11977 12608 319149 108989 19386 29817 69482 71805 52615 56717 15267 22084 110147 93739 66615 67841 75669 225326 213988 15516 21672 14957 56702 104248 15260 67526 16906 319168 11793 319167 217351 666468 22241 233833 78610 77040 67605 17246 56716 214150 56486 242557 74781 50493 12421 66795 228361 235040 218978 68118 14775 319594 245860 74244 12359 57436 51897 17454 213948 54636 66840 FORMATION OF A POOL OF FREE 40S SUBUNITS%REACTOME DATABASE ID RELEASE 57%72689 Formation of a pool of free 40S subunits 76808 68028 100043755 19899 67186 20115 57294 667739 67025 27370 65019 67248 666669 100038991 100038875 100040021 432502 66481 100040298 238217 56040 667618 19989 67891 100042986 100042740 621100 100043295 67097 100043000 66235 625646 67281 633683 666899 667035 55944 16785 13669 100039316 27979 267019 68135 100040970 66085 53356 56347 223691 19941 382492 73830 20055 16341 19951 100042807 100042670 54709 68193 665189 668182 98221 19921 20044 668144 100043423 100043893 670832 100043876 629957 225058 22121 75617 667279 76846 27050 100043184 19934 100040331 100043391 319195 68172 241053 100043209 20102 67941 27207 668668 20103 672214 622534 20085 20084 GLYCOGEN STORAGE DISEASES%REACTOME%R-HSA-3229121.2 Glycogen storage diseases 27357 22190 53412 232493 667035 14936 13853 REGULATED PROTEOLYSIS OF P75NTR%REACTOME%R-HSA-193692.1 Regulated proteolysis of p75NTR 18033 19165 59287 100039623 100042305 208117 22034 11491 18053 19697 CD209 (DC-SIGN) SIGNALING%REACTOME DATABASE ID RELEASE 57%5621575 CD209 (DC-SIGN) signaling 18749 17096 12914 328572 15896 19697 18176 18033 110157 18481 73086 19698 170786 14360 18479 16653 15461 18747 224105 PRE-NOTCH PROCESSING IN GOLGI%REACTOME%R-HSA-1912420.2 Pre-NOTCH Processing in Golgi 19719 16848 17305 18550 54613 14595 19346 11938 53313 11937 100042343 18131 20443 18129 18128 20338 18132 ARACHIDONIC ACID METABOLISM%REACTOME%R-HSA-2142753.3 Arachidonic acid metabolism 64292 11684 96979 15446 245533 11687 13110 13077 19225 19224 14776 106648 100040843 72054 17250 18783 17164 19223 100043508 16993 105349 13120 320997 631304 13118 13124 21391 208285 11690 13078 625249 17001 11689 13479 71854 66469 319446 107141 13076 71519 72303 54486 12408 14073 23887 19215 13850 11688 11686 67103 14775 14598 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS%REACTOME DATABASE ID RELEASE 57%205043 NRIF signals cell death from the nucleus 208117 18053 22190 67733 667035 19165 18049 59287 18412 100039623 26419 100042305 22034 RECOGNITION AND ASSOCIATION OF DNA GLYCOSYLASE WITH SITE CONTAINING AN AFFECTED PYRIMIDINE%REACTOME%R-HSA-110328.1 Recognition and association of DNA glycosylase with site containing an affected pyrimidine 382913 17193 71726 18207 18294 72774 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS%REACTOME%R-HSA-451306.1 Ionotropic activity of Kainate Receptors 13385 110637 13383 640703 14807 14805 53310 14806 52589 14809 CELL-CELL COMMUNICATION%REACTOME DATABASE ID RELEASE 57%1500931 Cell-Cell communication 20740 668101 18759 14083 12361 54353 17973 15170 74769 20742 12821 18709 22323 14360 56513 23880 16480 12557 12737 12554 11727 19353 56173 12738 71908 12388 19303 12560 11474 239857 12565 114141 54420 12552 12740 21754 53624 57342 320873 225341 68794 241201 26419 74202 20163 16202 170736 218952 56217 56863 26416 94332 58235 12741 93742 239096 67703 75677 12488 56492 243911 58998 12739 12564 71740 58187 242653 93737 12695 12476 239931 12562 11472 18417 50791 12563 58220 224912 18208 54419 114873 60363 13508 54725 16456 19229 621628 64945 215654 22177 19247 29857 19094 29875 13176 60595 19261 26415 12555 12558 18810 18479 16423 12561 12550 192176 12385 16774 109711 73178 73341 16403 18708 18706 16782 16780 19294 17974 192897 16412 PEPTIDE LIGAND-BINDING RECEPTORS%REACTOME%R-HSA-375276.2 Peptide ligand-binding receptors 58182 246313 23832 319430 14763 18217 22045 217369 20312 246691 20299 12772 22044 20302 13051 252837 280287 12458 208188 14061 14063 12424 12209 12425 13618 24111 18101 68039 171469 114229 23925 67405 16963 226278 13615 13614 54199 20303 20295 20306 20296 20292 50501 13616 13617 623503 22439 20290 14829 59289 12000 18167 12767 76854 18168 12854 56838 227288 12765 217212 18610 225642 330122 18390 26361 11820 54140 19065 12774 19064 18619 100038965 20606 100039973 110312 17329 14065 12145 18429 18430 14825 14062 12775 12776 20310 12778 12768 14064 12771 12773 381073 19156 23919 15199 56066 239336 12273 109648 15139 20315 11609 17200 15945 18386 104443 230777 12266 20609 229214 12267 14427 11607 237362 18389 15171 14429 14428 14293 16952 20608 21338 55985 54615 11606 208990 14289 227717 14294 387285 20297 18166 20210 14419 21333 18155 20304 21334 30878 21337 20604 216749 11998 57349 20293 56744 242093 66102 21336 12769 385643 319239 212108 100043254 17202 17199 17201 17203 16336 18216 12426 224065 13349 18976 226304 12766 12062 18387 80901 14767 19773 12777 56183 12061 20605 433292 20311 20300 23796 20607 207911 381489 140498 DEFECTIVE LFNG CAUSES SCDO3%REACTOME%R-HSA-5083630.1 Defective LFNG causes SCDO3 18131 18129 18128 18132 G-PROTEIN BETA:GAMMA SIGNALLING%REACTOME DATABASE ID RELEASE 57%397795 G-protein beta:gamma signalling 16186 18796 104709 18795 16184 11848 16185 16452 30955 14706 11652 14696 18710 11651 16451 14688 14708 16453 14693 18797 320207 14709 14697 20416 14699 66066 14700 14701 14389 16188 23797 18708 14695 18706 14704 74769 14702 16183 14710 18707 64337 18709 18607 12981 16192 12982 16191 12984 NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION%REACTOME DATABASE ID RELEASE 57%164940 Nef mediated downregulation of MHC class I complex cell surface expression 108012 107975 11768 12010 11769 252903 11765 15007 11764 11767 SELENOAMINO ACID METABOLISM%REACTOME%R-HSA-2408522.1 Selenoamino acid metabolism 23972 23971 76808 68028 100043755 19899 67186 20115 57294 667739 67025 27370 65019 67248 666669 100038991 100038875 100040021 432502 66481 100040298 238217 56040 667618 19989 107869 12411 21743 269378 18113 11720 50880 67891 140483 100042986 100042740 621100 100043295 67097 100043000 625646 67281 633683 666899 667035 16785 100039316 267019 100040970 14711 211006 65967 19941 214580 382492 75420 20055 20226 19951 100042670 68193 665189 668182 19921 20044 668144 100043423 100043893 670832 100043876 629957 225058 22121 75617 667279 76846 27050 100043184 104458 19934 226414 100040331 85305 100043391 319195 50493 107045 68172 241053 100043209 66143 20102 97541 67941 13722 27207 668668 20103 231872 672214 107508 622534 216443 20085 105148 20084 SIGNALING BY ROBO RECEPTOR%REACTOME DATABASE ID RELEASE 57%376176 Signaling by Robo receptor 259302 19353 18643 14270 18645 20662 18479 268902 11352 17973 20663 76707 14026 12331 11350 70584 241656 214230 18481 76499 17974 22323 117600 223666 20563 14733 19876 67252 224105 GLUCOSE TRANSPORT%REACTOME%R-HSA-70153.1 Glucose transport 218210 66679 18226 69912 20528 227720 54563 223921 103468 70699 72787 14385 14377 103988 231103 20526 269113 231042 234865 69736 56636 19069 107939 170762 20525 68401 14378 20527 59015 227699 18141 445007 15275 15277 108989 19386 69482 71805 212032 FORMYL PEPTIDE RECEPTORS BIND FORMYL PEPTIDES AND MANY OTHER LIGANDS%REACTOME%R-HSA-444473.1 Formyl peptide receptors bind formyl peptides and many other ligands 20210 11820 15199 14293 16952 14289 14294 FRS-MEDIATED FGFR1 SIGNALING%REACTOME%R-HSA-5654693.1 FRS-mediated FGFR1 signaling 56438 26395 67603 319520 235584 26403 16416 12223 54519 100042150 21894 11600 19060 19186 19188 327826 17169 194231 109905 14161 226525 57296 67151 215449 19185 66998 53380 14172 17967 15461 17463 83409 69077 29875 26417 26413 12323 108058 12322 18015 59029 19197 19417 19184 19179 22190 20422 171463 14573 667035 19182 16590 240057 19181 231474 64654 80903 14173 23997 14164 66997 18039 218397 110135 14585 14178 80857 228769 14180 70247 67089 14586 14587 14175 21762 14177 23996 20416 11876 14165 26554 18596 109880 16399 54153 15200 640703 18673 12325 16706 69601 83379 22371 73902 233046 114716 12981 19415 63953 14174 12982 19252 16653 12984 240672 13537 12988 67836 16186 13385 14588 211323 16184 11836 18188 20740 20739 13645 16185 16452 216869 109689 18176 72399 70686 114715 240168 14268 66413 211255 18183 14083 16451 19192 16453 26445 19166 18218 14812 76089 26444 26446 14811 26443 14813 19414 80297 14814 16183 20742 20741 21687 20743 16367 13866 14810 16192 26396 14360 16191 216148 114713 14186 19418 22123 20662 19052 14170 19053 19262 73699 640524 16913 75590 19175 19177 51792 19713 19170 22330 99571 13874 103554 16912 54401 83961 16188 19173 19172 21770 26932 107971 226849 100986 18611 23980 26931 20418 225849 320484 384783 245684 67112 110157 19167 26441 19419 11472 19171 545987 13649 70727 18595 26442 26440 101809 18591 19247 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF SATURATED FATTY ACIDS%REACTOME DATABASE ID RELEASE 57%77286 mitochondrial fatty acid beta-oxidation of saturated fatty acids 15107 93747 11364 231086 11370 97212 11363 11409 RETROGRADE TRANSPORT AT THE TRANS-GOLGI-NETWORK%REACTOME DATABASE ID RELEASE 57%6811440 Retrograde transport at the Trans-Golgi-Network 17113 76899 67542 69834 233824 242406 74375 76688 78689 319642 73296 53330 232286 108123 19346 54214 108124 78304 226089 70297 97484 68299 76332 56367 18195 270192 224705 70646 56382 22319 16004 102339 228960 76932 227746 338337 53611 16834 104303 58244 245944 17957 66905 98910 68505 SYNTHESIS OF KETONE BODIES%REACTOME DATABASE ID RELEASE 57%77111 Synthesis of Ketone Bodies 208982 78894 15360 110446 69772 15356 71911 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES%REACTOME%R-HSA-499943.4 Synthesis and interconversion of nucleotide di- and triphosphates 22166 66588 229949 14923 635960 11637 20135 433968 18102 56520 382985 67725 50493 21915 108143 93692 11636 55936 51797 66422 20133 78801 68870 MHC CLASS II ANTIGEN PRESENTATION%REACTOME%R-HSA-2132295.1 MHC class II antigen presentation 20334 209737 16563 16573 218811 11772 19025 668303 20404 252903 11840 74947 11771 16569 56455 19349 71770 77371 59288 71819 232943 13191 68097 108012 11768 54130 12757 69162 232910 13038 19141 13430 11773 11767 26934 103967 20743 13033 13036 13040 13427 14960 13424 99683 14968 110350 226977 19348 14969 11765 11764 110379 69654 56464 16571 16579 13039 15001 53598 280408 16149 13032 213575 14998 69608 12330 67300 13030 66397 13429 229445 73470 15000 15002 13034 16568 16570 16572 73804 67665 74764 234663 11769 22428 64291 228421 110033 229841 65972 13426 16593 16594 16551 TRANSPORT OF GLYCEROL FROM ADIPOCYTES TO THE LIVER BY AQUAPORINS%REACTOME%R-HSA-432030.1 Transport of glycerol from adipocytes to the liver by Aquaporins 11832 64008 CLASSICAL KIR CHANNELS%REACTOME%R-HSA-1296053.1 Classical Kir channels 16518 16515 16520 211480 FMO OXIDISES NUCLEOPHILES%REACTOME DATABASE ID RELEASE 57%217271 FMO oxidises nucleophiles 14262 14261 55990 RHO GTPASES ACTIVATE IQGAPS%REACTOME DATABASE ID RELEASE 57%5626467 RHO GTPases activate IQGAPs 12385 19353 544963 17283 404710 640703 12387 56430 12550 29875 PI3K AKT ACTIVATION%REACTOME%R-HSA-198203.2 PI3K AKT activation 211323 13645 18049 18211 18183 12576 12575 74769 18707 18709 16367 13866 14360 14186 11848 19052 14170 19053 73699 51792 13874 56637 83961 21770 26932 226849 26931 225849 384783 12675 67112 13649 18595 18591 12223 16334 76850 100042150 236511 19247 16337 75778 15370 327826 12519 12524 18710 14172 12912 26417 26413 606496 244650 12015 56717 22084 77647 239528 12371 98432 16590 117150 64654 56458 14173 56484 80903 14164 213988 11652 18717 12478 11651 15937 14178 80857 14180 78757 228775 12487 14175 14177 217351 14165 18596 233833 23797 18708 15200 67605 18706 18720 17246 56716 16818 18719 214150 108083 83379 18607 14388 22324 14174 19211 227743 18718 109270 17454 58988 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES%REACTOME%R-HSA-1169410.1 Antiviral mechanism by IFN-stimulated genes 218210 66679 18226 100039592 69912 227720 54563 22194 223921 103468 16211 70699 16648 16649 72787 54131 74153 16451 269113 231042 234865 69736 19069 16646 107939 66892 170762 230861 112419 23806 17999 13690 24110 19043 26417 286940 59015 227699 18141 208643 192170 445007 108989 19386 69482 71805 56791 100038882 22190 667035 18803 13684 217069 13682 93765 20846 13681 23988 19106 381686 230073 DEFECTIVE C1GALT1C1 CAUSES TN POLYAGGLUTINATION SYNDROME (TNPS)%REACTOME DATABASE ID RELEASE 57%5083632 Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) 17829 224116 269328 100039649 353328 73732 17063 140474 MITOCHONDRIAL TRANSLATION TERMINATION%REACTOME DATABASE ID RELEASE 57%5419276 Mitochondrial translation termination 56284 56282 24030 320806 14548 67707 94061 69956 94067 107734 68611 67681 74600 78523 66419 60441 56280 121022 69527 66407 77721 66230 68537 67994 28028 64655 66242 68565 69163 67840 68735 27398 67871 65111 216767 67308 66047 52443 66163 64657 99045 118451 108853 64656 79044 59054 27397 66493 67036 218506 94063 353242 64660 68499 66973 75398 107732 66223 27393 68836 67212 18120 66121 50529 66258 57312 623346 232536 102060 94062 64659 107733 68463 622268 66845 66077 94065 66292 100042811 66448 18100 94066 64658 68572 100040519 INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME%R-HSA-109606.1 Intrinsic Pathway for Apoptosis 22062 11783 21981 12369 12015 12367 100039786 12371 12370 66593 12028 18107 56455 11652 26419 11651 22627 209456 22061 55948 68097 54401 12122 670717 22059 23797 22631 12043 12125 22629 12048 22628 13555 21781 19058 12018 11798 19057 14939 171543 DEGRADATION OF GABA%REACTOME DATABASE ID RELEASE 57%916853 Degradation of GABA 268860 214579 NUCLEOSOME ASSEMBLY%REACTOME%R-HSA-774815.1 Nucleosome assembly 320394 15267 12615 319183 19646 72155 319181 60411 56505 319182 319178 319186 319190 69928 232440 52504 217653 70645 66578 319168 71876 93762 382522 319167 70454 319176 67733 83815 102920 66311 76464 20892 100038822 66570 233532 18148 624153 51788 66336 12617 319188 15270 319169 78303 245688 26886 EUKARYOTIC TRANSLATION INITIATION%REACTOME%R-HSA-72613.1 Eukaryotic Translation Initiation 76808 68028 100043755 19899 67186 20115 57294 667739 67025 27370 65019 67248 666669 100038991 100038875 100040021 432502 66481 100040298 238217 56040 667618 19989 66235 55944 13669 27979 68135 66085 26905 22384 53356 56347 13684 67204 223691 217869 13682 73830 16341 100042807 13681 54709 75705 98221 13685 13665 208643 18458 67891 100042986 100042740 621100 100043295 67097 100043000 625646 67281 633683 666899 667035 16785 100039316 267019 100040970 19941 382492 20055 19951 100042670 68193 665189 209354 668182 13667 19921 217715 20044 108067 668144 100043423 100043893 670832 100043876 629957 225058 22121 75617 667279 76846 27050 100043184 19934 100040331 100043391 319195 68172 241053 100043209 20102 67941 27207 668668 20103 672214 226982 622534 224045 20085 20084 ABACAVIR TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 57%2161517 Abacavir transmembrane transport 26357 20517 20519 18671 20518 DOWNSTREAM SIGNALING OF ACTIVATED FGFR3%REACTOME%R-HSA-5654708.1 Downstream signaling of activated FGFR3 56438 26395 67603 319520 235584 26403 16416 12223 54519 100042150 21894 11600 19060 19186 19188 327826 17169 194231 109905 14161 226525 57296 67151 215449 18710 19185 66998 53380 14172 17967 15461 17463 83409 69077 29875 12912 26417 26413 12323 108058 12322 18015 59029 19197 19417 19184 19179 22190 20422 171463 14573 667035 19182 16590 240057 19181 231474 64654 80903 14173 23997 14164 66997 18039 218397 110135 14585 14178 80857 228769 14180 70247 67089 14586 14587 14175 21762 14177 23996 20416 11876 14165 26554 18596 109880 16399 18708 54153 15200 640703 18706 18673 12325 16818 16706 69601 83379 22371 73902 233046 114716 12981 19415 63953 14174 12982 19252 16653 12984 240672 13537 12988 67836 16186 13385 14588 211323 16184 11836 18188 20740 20739 13645 16185 16452 216869 109689 18176 72399 70686 114715 240168 14268 66413 211255 18183 14083 16451 19192 16453 26445 19166 18218 12576 14812 76089 26444 26446 14811 26443 14813 19414 80297 14814 12575 74769 16183 20742 18707 18709 20741 21687 20743 16367 13866 14810 16192 26396 14360 16191 216148 114713 14186 19418 22123 20662 19052 14170 19053 19262 73699 640524 16913 75590 19175 19177 51792 19713 19170 22330 99571 13874 103554 16912 54401 83961 56637 16188 19173 19172 21770 107971 26932 100986 226849 18611 23980 20418 26931 320484 225849 384783 12675 245684 67112 110157 19167 26441 19419 11472 19171 545987 13649 70727 18595 26442 26440 101809 18591 18750 19088 16334 76850 18753 18754 236511 19247 16337 75778 15370 18752 104110 229709 12519 12524 606496 244650 18573 12015 56717 22084 224129 77647 11513 11512 239528 11515 11514 12371 98432 117150 18803 56458 56484 213988 12326 11652 18717 12478 11651 15937 16440 78757 228775 12487 110355 18747 18574 16438 18749 217351 210044 18575 432530 233833 23797 104111 67605 18720 17246 56716 18719 214150 108083 19087 19085 18607 19084 14388 22324 19211 227743 18718 109270 17454 16439 58988 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME%R-HSA-110381.1 Resolution of AP sites via the single-nucleotide replacement pathway 22594 11792 18970 16882 SIGNALING BY VEGF%REACTOME DATABASE ID RELEASE 57%194138 Signaling by VEGF 15507 17973 57257 20430 230126 83767 242687 18127 22325 15519 330662 18481 56438 224105 19353 13057 26395 67603 13058 319520 17970 17972 17969 102626 18187 235584 26362 27371 26403 18186 16416 12223 54519 100042150 21894 11600 19060 19186 19188 327826 17169 194231 109905 14161 226525 57296 67151 215449 19185 66998 53380 14172 17967 15461 17463 83409 69077 29875 17164 22341 26417 22340 26413 14205 12323 108058 12322 18015 59029 19197 19417 19184 22190 19179 20422 171463 667035 14573 19182 16590 240057 19181 64654 231474 14173 80903 14164 23997 66997 18039 218397 110135 14585 14178 80857 228769 14180 70247 67089 14586 14587 14175 21762 14177 23996 20416 12385 11876 14165 26554 18596 109880 16399 54153 18708 15200 640703 18706 18673 12325 16706 69601 83379 22371 73902 233046 114716 12981 19415 63953 14174 12982 19252 16653 12984 240672 13537 12988 67836 16186 13385 14588 211323 16184 11836 18188 20740 20739 13645 16185 16452 216869 109689 18176 72399 70686 114715 240168 14268 66413 211255 18183 14083 16451 19192 16453 26445 19166 18218 14812 76089 26444 26446 14811 26443 14813 19414 80297 14814 74769 16183 20742 18709 20741 21687 20743 16367 13866 14810 16192 26396 14360 16191 216148 114713 14186 19418 22123 16480 12927 11848 19303 12388 22339 20662 19052 14170 12389 19053 19262 73699 640524 16913 75590 19175 19177 51792 19713 19170 22330 99571 13874 103554 16912 26416 54401 83961 16188 19173 19172 21770 107971 26932 100986 226849 18611 23980 20418 26931 320484 225849 384783 245684 67112 110157 19167 26441 19419 12562 11472 19171 545987 13649 70727 18595 26442 26440 19229 101809 18591 18750 18753 75778 229709 18762 18751 29857 20698 19094 16542 14254 105855 245880 19877 56717 140580 50884 108100 26415 329165 101314 140579 19878 18803 11652 76884 11651 18654 12928 16440 18479 78757 228775 18747 14257 16438 18749 23797 11308 56716 18607 22324 17974 227743 109270 16439 16410 BINDING OF TCF LEF:CTNNB1 TO TARGET GENE PROMOTERS%REACTOME DATABASE ID RELEASE 57%4411364 Binding of TCF LEF:CTNNB1 to target gene promoters 21414 21416 16842 12006 21415 12387 17869 RNA POLYMERASE I TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 57%73762 RNA Polymerase I Transcription Initiation 18519 66136 116870 21341 21340 20017 110147 19646 70333 21374 17749 667501 66420 22130 245841 107932 66467 21429 234366 75316 216848 64424 20016 14534 20018 106298 20019 21339 14884 23942 66671 319955 433759 23894 15182 12572 17192 17420 13871 13872 116871 209357 69833 14885 100043714 245688 229542 PTK6 REGULATES RTKS AND THEIR EFFECTORS AKT1 AND DOK1%REACTOME%R-HSA-8849469.1 PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 69710 13448 20459 11651 22190 667035 12402 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT%REACTOME DATABASE ID RELEASE 57%159236 Transport of Mature mRNA derived from an Intron-Containing Transcript 218210 193116 66679 107829 18226 110809 225027 60365 69912 331401 66511 68278 227720 54563 223921 19826 103468 67996 70699 73666 20382 53817 72787 71713 70579 66231 69823 233073 73826 56488 69207 108014 269113 231042 386612 234865 69736 17149 19069 100040029 107939 170762 192160 625193 59015 225160 227699 68092 66441 18141 433702 64340 192170 445007 622469 51796 108989 19386 21681 20383 69482 68134 71805 53319 ACTIVATION, TRANSLOCATION AND OLIGOMERIZATION OF BAX%REACTOME DATABASE ID RELEASE 57%114294 Activation, translocation and oligomerization of BAX 12122 12028 MICROTUBULE-DEPENDENT TRAFFICKING OF CONNEXONS FROM GOLGI TO THE PLASMA MEMBRANE%REACTOME%R-HSA-190840.1 Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane 14609 CLASS B 2 (SECRETIN FAMILY RECEPTORS)%REACTOME%R-HSA-373080.1 Class B 2 (Secretin family receptors) 14370 22415 14368 14365 13363 14367 22423 22418 20423 16147 57265 20287 11517 22416 14706 216795 14607 14696 14526 14527 11516 14602 51801 14688 20890 223780 14708 11535 14693 12311 14709 12310 22417 56089 14601 15874 54409 14697 22408 19206 319757 14362 14366 14369 114640 22411 54598 22410 14699 13733 66066 22414 14700 93735 19228 14701 19207 213527 26364 22421 22422 12922 14695 93896 22412 14652 14371 14704 14702 381853 14710 64337 12918 19226 12921 22409 19227 93897 22413 22420 TRANSMISSION ACROSS ELECTRICAL SYNAPSES%REACTOME DATABASE ID RELEASE 57%112307 Transmission across Electrical Synapses 14615 14617 55991 14610 406218 TRNA PROCESSING IN THE MITOCHONDRION%REACTOME%R-HSA-6785470.2 tRNA processing in the mitochondrion 70047 15108 66132 68626 52575 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 57%210500 Glutamate Neurotransmitter Release Cycle 20513 12889 22318 68507 327814 19339 22249 20510 20512 20511 233977 242607 20907 20614 216456 65106 67760 14660 20979 SYNTHESIS OF 15-EICOSATETRAENOIC ACID DERIVATIVES%REACTOME DATABASE ID RELEASE 57%2142770 Synthesis of 15-eicosatetraenoic acid derivatives 625249 11688 14775 19225 14776 11687 PDE3B SIGNALLING%REACTOME DATABASE ID RELEASE 57%165160 PDE3B signalling 11652 18576 ACETYLCHOLINE REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 57%399997 Acetylcholine regulates insulin secretion 14682 18796 18750 17118 14675 18795 12671 14676 14672 18797 NUCLEOTIDE METABOLISM%REACTOME DATABASE ID RELEASE 57%15869 Nucleotide metabolism 57813 215446 23959 21877 13178 56749 50773 103850 22245 93685 22247 22171 12495 103149 12497 67365 12496 268782 67464 76654 72090 72269 12499 80914 64705 22271 72962 108143 69719 230718 99586 320685 66358 231327 214254 11821 53893 75686 22166 635960 11637 433968 18102 56520 67725 21915 93692 11636 55936 51797 66422 20133 78801 68870 27369 108147 16434 14450 14544 66588 229949 11717 14923 109674 67054 23917 11564 22436 20135 100042069 66355 237823 229665 11566 75894 382985 11534 105446 76952 50493 14775 76429 12359 229363 11486 15452 18950 11565 SYNDECAN INTERACTIONS%REACTOME DATABASE ID RELEASE 57%3000170 Syndecan interactions 18750 16416 109711 22370 16403 16398 20971 20969 21825 20970 60409 14173 16419 15529 21803 192897 16412 16410 12361 21923 JOSEPHIN DOMAIN DUBS%REACTOME%R-HSA-5689877.1 Josephin domain DUBs 110616 22190 19358 667035 19359 50873 66124 269523 BETA-CATENIN PHOSPHORYLATION CASCADE%REACTOME%R-HSA-196299.1 Beta-catenin phosphorylation cascade 14296 11789 56637 93687 72345 21770 26932 226849 12005 212398 26931 225849 19052 19053 73699 51792 AXON GUIDANCE%REACTOME%R-HSA-422475.3 Axon guidance 12827 12289 12295 12829 12297 12839 20452 12298 12830 12835 12833 11603 12828 12826 59287 13636 13838 13839 13836 13840 69585 13841 114255 13638 76829 230126 623279 20562 76707 68799 210801 244058 13639 20564 13430 13637 22253 13842 216439 13835 18738 13000 103967 100039026 18481 76499 56438 18222 13640 13837 67252 224105 26395 67603 319520 13844 12661 11658 70584 216963 241656 214230 319713 73086 226251 231148 213119 53870 18187 56705 110596 235584 104099 26403 18186 16416 12223 22177 16402 54519 100042150 21894 11600 19060 19186 19188 327826 17169 194231 109905 14161 226525 57296 67151 13193 215449 12805 18710 53378 19185 53321 66998 53380 14172 17967 268902 15461 17463 83409 69077 29875 110651 20111 12912 26417 26413 23939 20112 109700 12323 108058 12322 18015 59029 19197 19417 19184 13001 17390 19179 20422 171463 14573 19182 16590 240057 19181 231474 80903 23997 66997 18039 218397 17395 110135 13429 14585 14178 228769 70247 67089 14586 14587 21762 23996 20416 11876 14165 26554 18596 109880 16399 54153 18761 15200 640703 18673 83433 12325 16706 69601 16886 83379 22371 73902 233046 114716 12981 19415 63953 14174 12982 19252 16653 12984 240672 17904 13537 12988 67836 16186 13385 14588 211323 16184 11836 18188 20740 11772 20739 13645 16185 16452 216869 109689 18176 72399 545156 11771 70686 114715 71770 240168 14268 66413 211255 18183 14083 16451 19192 16453 26445 19166 18218 14812 76089 26444 26446 14811 26443 14813 12757 19414 232910 80297 14814 74769 11773 16183 20742 18707 18709 20741 21687 20743 16367 13866 14810 16192 26396 14360 16191 216148 114713 14186 19418 22123 232906 16571 11848 20662 14170 22063 19262 640524 67300 22065 16913 75590 19175 19177 19713 19170 22330 99571 13874 103554 22066 16912 54401 83961 16188 19173 19172 107971 22068 100986 12331 18611 23980 20418 22067 320484 384783 245684 67112 110157 19167 26441 19419 11472 235611 19171 17295 545987 20354 13649 223881 70727 18595 26442 26440 101809 18591 18750 11487 54126 19247 26946 20404 13848 270190 13845 13641 13846 15481 13643 13642 19877 16772 16777 18803 18717 13449 18007 18747 213498 11352 12840 214968 18749 12296 67784 58226 140571 12291 20663 243743 12288 12834 208117 18845 20450 16398 19122 245026 239556 21367 12841 223435 12292 19165 226519 100039623 14388 100042305 15529 69632 20358 21844 12517 20349 16412 18844 57764 54712 53972 16410 20361 20351 74947 17973 17096 57257 56378 12631 22325 11350 15519 330662 66713 22323 19264 259302 19353 14270 53310 117600 223666 18208 20563 14733 19876 58234 12568 13176 107448 13004 107449 18846 227377 20346 22190 667035 64654 14173 14164 80857 14180 11733 14175 16443 11735 14177 74325 14389 18708 18706 56613 22350 17698 19684 12934 71653 14159 67071 12569 110351 19052 19053 73699 20130 13383 51792 56637 21770 26932 226849 26931 225849 20437 20356 16542 72821 16728 110862 319504 16536 20266 235281 24046 20265 71960 20269 110880 67938 14783 67268 12933 22240 26757 56443 18643 65254 18645 11461 16885 14786 19878 20264 269116 399548 15516 20271 17886 20272 56212 20273 13448 20274 110876 22612 19354 18479 11852 76709 17909 11465 73178 11853 20439 68089 74117 14026 67771 11867 17880 17974 77579 SPHINGOLIPID METABOLISM%REACTOME%R-HSA-428157.1 Sphingolipid metabolism 19156 20773 545975 56632 242083 79554 56491 19025 66183 223753 52635 20698 76893 66190 20598 11881 238011 11886 11883 70750 272636 433323 103236 74008 20597 58994 54447 104725 14421 15212 545260 14420 74442 15211 227102 18010 66612 12091 77626 23956 208449 93898 67902 22234 171168 20397 67260 19012 50784 268656 22239 50877 56356 76303 67916 230379 58911 14667 14466 71949 30960 23943 77041 241447 13244 338521 70059 230101 18760 11605 228677 271970 81535 66844 67689 FORMATION OF HIV-1 ELONGATION COMPLEX CONTAINING HIV-1 TAT%REACTOME%R-HSA-167200.2 Formation of HIV-1 elongation complex containing HIV-1 Tat 107951 67710 17749 66420 114741 245841 24116 66467 20021 20833 69241 20924 20922 14884 66671 23894 57314 27632 12572 17420 13871 13872 58202 209357 68092 69833 14885 13716 68705 433702 20022 67655 69920 231329 98053 67923 27224 100043714 20020 12455 21399 PROLACTIN RECEPTOR SIGNALING%REACTOME%R-HSA-1170546.1 Prolactin receptor signaling 20851 20850 12234 21402 26965 56438 19247 19109 14600 19116 16452 PCP CE PATHWAY%REACTOME%R-HSA-4086400.2 PCP CE pathway 14370 18750 93840 66313 13543 14368 14365 14367 75788 22418 11772 57265 19186 19188 18752 20187 216869 11771 18751 57296 71770 67151 66413 19185 66998 53380 19192 26445 17463 19166 22417 69077 22408 26444 26446 26443 12757 232910 11773 14362 56513 106042 14366 14369 105782 22123 170758 59029 19353 18643 19184 11848 19179 22190 20422 667035 19182 19181 23997 67300 66997 22411 16913 19354 228769 19175 70247 19177 67089 19170 21762 23996 103554 16912 208846 74325 19173 19172 13542 13544 73902 19167 26441 19171 22419 26564 26563 26442 26440 SPHINGOLIPID DE NOVO BIOSYNTHESIS%REACTOME%R-HSA-1660661.3 Sphingolipid de novo biosynthesis 20773 545975 56632 93898 242083 56491 66183 171168 20397 67260 20698 19012 76893 50784 268656 66190 76303 67916 230379 70750 433323 103236 71949 30960 241447 13244 104725 338521 70059 18760 74442 227102 228677 66612 81535 66844 67689 208449 SIGNALING BY FGFR2 FUSIONS%REACTOME DATABASE ID RELEASE 57%8853333 Signaling by FGFR2 fusions 14183 SIGNALING BY EGFR IN CANCER%REACTOME%R-HSA-1643713.1 Signaling by EGFR in Cancer 20416 18708 22190 18706 13645 667035 12402 15519 18176 18803 20662 12539 14388 13649 16653 15461 VITAMIN B5 (PANTOTHENATE) METABOLISM%REACTOME DATABASE ID RELEASE 57%199220 Vitamin B5 (pantothenate) metabolism 269614 106564 72621 330064 14104 67618 74450 73132 71743 75735 211347 66812 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN%REACTOME%R-HSA-1234174.1 Regulation of Hypoxia-inducible Factor (HIF) by oxygen 11863 13819 22346 12914 71745 230099 112406 53417 112407 328572 15251 22190 22339 13856 17684 667035 100041766 216080 66105 56438 67923 319594 TFAP2 (AP-2) FAMILY REGULATES TRANSCRIPTION OF OTHER TRANSCRIPTION FACTORS%REACTOME%R-HSA-8866906.1 TFAP2 (AP-2) family regulates transcription of other transcription factors 21418 18741 17684 21420 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A%REACTOME DATABASE ID RELEASE 57%174184 Cdc20:Phospho-APC C mediated degradation of Cyclin A 66156 52206 668450 12237 19186 22194 19188 56150 75430 216080 57296 67151 66413 19185 66998 53380 52717 19192 26445 17463 19166 69077 26444 26446 26443 52563 99152 12534 69957 68999 68612 17222 22123 59029 19184 19179 22190 12236 20422 667035 19182 12427 19181 23997 66997 16913 228769 70247 19175 19177 67089 19170 21762 23996 103554 16912 19173 19172 59008 56317 73902 19167 26441 107995 19171 217232 26442 26440 12428 PHASE 3 - RAPID REPOLARISATION%REACTOME DATABASE ID RELEASE 57%5576890 Phase 3 - rapid repolarisation 16511 66240 246133 57442 16535 100986 57814 16509 PLATELET DEGRANULATION%REACTOME DATABASE ID RELEASE 57%114608 Platelet degranulation 13645 14268 11806 22145 21857 12631 20692 239273 232345 268373 21808 22339 11674 12527 21825 12491 22138 11820 21803 21809 22330 99571 215789 11804 27359 223601 12331 67988 21859 20363 75396 74145 11537 12759 14069 11472 18613 14067 18591 66866 19156 16416 109232 20255 74840 20344 14828 21767 19073 21894 80884 13601 108101 16784 21346 56541 117586 67059 20716 268936 16000 14161 22388 80718 16002 94175 26968 11747 11625 227612 19039 71946 13041 667310 15234 240334 68038 18407 16427 12512 218454 104009 18816 53612 20703 12321 20911 72017 22341 67072 16426 235505 22340 57349 56744 11818 54216 21922 60595 27999 56055 12258 385643 71660 68117 320202 14205 56193 70945 14456 18643 19128 110135 22041 192176 109711 16399 640703 22371 18815 11657 18787 CYCLIN D ASSOCIATED EVENTS IN G1%REACTOME DATABASE ID RELEASE 57%69231 Cyclin D associated events in G1 22190 667035 19052 19053 73699 100043858 21402 12580 12567 13559 12443 104394 51792 12444 66671 54124 12445 12579 12576 12578 71978 211586 19651 19650 26965 12571 13557 12572 19645 12575 17420 13555 21781 27401 242705 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA%REACTOME DATABASE ID RELEASE 57%3359475 Defective MMAA causes methylmalonic aciduria type cblA 17850 109136 VPR-MEDIATED INDUCTION OF APOPTOSIS BY MITOCHONDRIAL OUTER MEMBRANE PERMEABILIZATION%REACTOME%R-HSA-180897.1 Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization 11739 11740 433923 LYSINE CATABOLISM%REACTOME DATABASE ID RELEASE 57%71064 Lysine catabolism 235386 18293 217593 30956 12971 19193 78920 23923 110695 13382 270076 72947 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX%REACTOME%R-HSA-72695.1 Formation of the ternary complex, and subsequently, the 43S complex 67097 66235 633683 667035 55944 16785 13669 100039316 27979 267019 68135 66085 26905 53356 56347 67204 223691 382492 20055 73830 16341 100042807 54709 98221 13665 20044 668144 20115 57294 670832 667739 629957 27370 225058 75617 667279 76846 100038875 27050 20102 67941 27207 66481 668668 100040298 20103 20085 20084 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS%REACTOME%R-HSA-425366.1 Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds 214922 30791 67547 106947 72002 213053 106957 14977 227059 72027 243616 14411 14412 232333 21366 20538 240332 110877 103098 102680 170441 22598 104245 14664 56774 435818 20517 63993 18173 74338 13162 56636 56017 242259 68682 214084 27411 58176 70129 108052 20518 56315 19743 100434 213603 227659 233836 239606 239436 230810 66500 53945 20528 69048 22782 22784 210148 20537 64452 20526 56485 338365 70840 20521 18400 108114 20519 18174 30805 20520 242126 12870 15203 20500 19879 80879 18399 353169 67473 20525 57274 237831 230612 20501 114644 246787 20503 55961 53881 75750 20527 12215 117591 243755 13723 98396 20529 72045 SCAVENGING BY CLASS A RECEPTORS%REACTOME DATABASE ID RELEASE 57%3000480 Scavenging by Class A Receptors 12827 71693 14319 117158 140792 17167 12843 12826 12842 11806 12825 71145 14325 12317 22027 20288 238055 11816 REGULATION OF TLR BY ENDOGENOUS LIGAND%REACTOME DATABASE ID RELEASE 57%5686938 Regulation of TLR by endogenous ligand 12475 434174 16803 12491 21899 14161 20193 17087 20201 110135 24088 20202 21897 21898 238055 99571 MITOTIC G2-G2 M PHASES%REACTOME DATABASE ID RELEASE 57%453274 Mitotic G2-G2 M phases 76816 18817 77744 56455 76478 71909 219072 66413 214552 237222 20873 18536 104318 19192 22145 73738 26445 20878 19166 26370 74470 219103 17997 99100 74360 71978 68121 26444 18472 26446 27373 12009 26443 26965 13589 54130 76707 13557 230376 12572 66296 12575 236266 17420 78887 13555 18005 15519 19046 381644 22154 225745 214444 28135 231123 13427 13424 83922 208518 75786 18541 103733 101565 78177 22123 17274 69654 22153 225659 71648 16475 227613 19646 328572 17931 16328 53598 22142 68475 19052 19053 73699 21402 16913 19175 22627 51792 19177 103583 66671 19170 103554 16912 103768 51885 19173 75660 19172 100986 103573 629959 74237 19167 15366 26441 19171 231506 259279 12537 101706 26442 56299 26440 72568 21664 233276 19088 22390 19186 19188 14235 57296 67151 19185 66998 53380 17463 69077 12234 22059 22628 12531 12534 12566 12442 59029 72119 108000 19184 19179 22190 20422 667035 19182 12427 268930 19181 15516 23997 66997 228769 70247 67089 21762 18747 23996 29870 17865 75296 73902 12532 12530 12428 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS%REACTOME DATABASE ID RELEASE 57%77588 SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs 68092 20492 116748 384091 433702 243963 67332 20638 72290 666609 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24-HYDROXYCHOLESTEROL%REACTOME DATABASE ID RELEASE 57%193775 Synthesis of bile acids and bile salts via 24-hydroxycholesterol 19223 26459 83702 17117 104086 13116 77337 26458 105349 101502 208665 56050 13124 TAT-MEDIATED HIV ELONGATION ARREST AND RECOVERY%REACTOME DATABASE ID RELEASE 57%167243 Tat-mediated HIV elongation arrest and recovery 107951 67710 17749 66420 245841 114741 24116 20021 20833 69241 20924 20922 57314 27632 58202 69833 13716 68705 20022 67655 69920 231329 67923 98053 27224 100043714 20020 12455 21399 HIV INFECTION%REACTOME DATABASE ID RELEASE 57%162906 HIV Infection 252903 11840 12010 15007 56438 14375 224105 19353 108138 407786 12504 19186 19188 57296 67151 19185 66998 53380 17463 69077 12234 108012 11768 11767 68092 433702 11765 11764 59029 19184 19179 22190 20422 667035 19182 19181 23997 66997 228769 70247 67089 21762 23996 11769 16818 73902 22596 194309 67897 66914 24018 68776 18550 66464 83814 11772 235459 107305 209361 66467 18571 20833 99730 319944 18107 11771 24074 108143 71770 229906 100088 66413 83602 270627 20924 20922 75608 19192 66201 14884 26445 76959 19166 228980 16646 15361 26444 26446 26443 232910 12572 216185 11773 17420 14360 22123 268373 12767 107951 330192 20479 21374 12454 114741 24116 319583 19385 68953 21402 16913 19175 19177 66671 19170 52348 66700 103554 12774 16912 18108 22088 68153 74197 19173 23894 19172 57314 27632 116733 226182 105513 103573 13871 13872 58202 209357 208092 19167 14885 26441 13716 72504 67655 19171 21343 66371 67923 27224 26442 101739 19384 26440 72949 12455 21399 23825 218210 75717 66679 18226 67710 69912 17749 66420 245841 227720 108664 54563 11740 223921 94176 103468 70699 16211 20021 69241 433923 72787 269113 231042 234865 69736 19069 107939 170762 16881 14156 59015 227699 69833 18141 68705 20022 69920 445007 231329 98053 108989 19386 100043714 20020 69482 71805 140580 12487 15162 18148 11739 107975 12526 MITOTIC G1-G1 S PHASES%REACTOME%R-HSA-453279.1 Mitotic G1-G1 S phases 57813 18973 22171 18538 19891 68240 66413 19192 26445 19166 12579 12576 12578 17187 71978 26444 211586 26446 19651 19650 26443 26965 12571 13557 12572 19645 12575 17420 13555 21781 59001 27401 242705 66979 18974 68275 22123 19646 20459 19052 19053 13548 73699 100043858 21402 12580 12567 16913 13559 12447 12443 50793 19175 104394 19177 51792 12444 17869 19170 66671 54124 12445 16912 19173 75660 19172 629959 19167 26441 19171 231506 26442 26440 72568 70024 22390 19186 19188 57296 67151 27214 21973 19185 66998 53380 18392 26428 18393 26429 17463 69077 12448 433759 12544 12545 12534 12566 59029 18969 19075 19184 22190 19179 20422 667035 19182 12427 268930 19181 23997 66997 228769 70247 67089 21762 23996 17215 17219 17217 56452 66634 67177 67141 17865 20135 13361 23834 12530 17216 18968 19076 17220 12428 17218 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 57%187037 NGF signalling via TRKA from the plasma membrane 11517 11516 13430 103967 56438 17260 13712 26395 67603 100040260 319520 77480 102626 17258 73086 235584 26403 16416 12223 54519 100042150 21894 11600 19060 19186 19188 327826 17169 194231 109905 14161 226525 57296 67151 215449 18710 19185 66998 53380 14172 17967 15461 17463 83409 69077 29875 110651 17164 72349 20111 12912 26417 26413 23939 20112 12323 108058 12322 18015 59029 19197 19417 19184 19179 22190 20422 171463 14573 667035 19182 16590 240057 19181 64654 231474 14173 80903 14164 23997 66997 18039 218397 110135 13429 14585 20848 14178 80857 228769 14180 70247 67089 14586 14587 14175 21762 14177 23996 20416 11876 14165 26554 18596 109880 16399 18708 54153 15200 640703 18706 18673 12325 16818 16706 69601 83379 22371 73902 233046 114716 12981 19415 63953 14174 12982 19252 16653 12984 240672 13537 12988 67836 16186 13385 14588 211323 16184 11836 18188 20740 11772 20739 13645 16185 16452 216869 109689 18176 18049 72399 11771 70686 18211 114715 18212 240168 71770 14268 66413 211255 18183 14083 16451 19192 16453 26445 19166 56044 18218 12576 14812 76089 26444 26446 14811 26443 14813 12757 19414 232910 80297 14814 12575 74769 11773 16183 20742 18707 18709 20741 21687 20743 16367 13866 14810 16192 26396 14360 16191 216148 114713 14186 19418 22123 11848 20662 19052 14170 19053 19262 73699 640524 67300 16913 75590 19175 19177 51792 19713 19170 22330 99571 13874 103554 16912 26416 54401 83961 56637 16188 19173 19172 21770 107971 26932 100986 226849 18611 23980 20418 26931 320484 225849 384783 12675 245684 67112 110157 19167 26441 19419 11472 19171 545987 13649 70727 18595 26442 26440 101809 18591 18750 19088 16334 76850 18753 18754 236511 19247 16337 75778 15370 18752 104110 20404 229709 12519 12524 29857 19094 23938 54152 606496 244650 18573 12015 56717 22084 224129 77647 11513 11512 26415 239528 12929 11515 11514 12371 98432 117150 18803 56458 56484 213988 19730 12326 11652 18717 12478 11651 12928 15937 19769 16440 78757 228775 19762 12487 110355 18747 18574 16438 18749 217351 210044 18575 432530 233833 64143 23797 104111 67605 18720 11540 17246 56716 18719 214150 108083 19087 107746 19085 18607 19084 14388 22324 19211 227743 18718 109270 17454 16439 58988 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION)%REACTOME%R-HSA-2173791.1 TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) 14225 75788 11848 93742 22190 667035 18762 70737 21803 56513 21813 21812 16456 102098 FRS2-MEDIATED ACTIVATION%REACTOME%R-HSA-170968.1 Frs2-mediated activation 56438 26395 67603 319520 235584 26403 16416 12223 54519 100042150 21894 11600 19060 19186 19188 327826 17169 194231 109905 14161 226525 57296 67151 215449 19185 66998 53380 14172 17967 15461 17463 83409 69077 29875 26417 26413 12323 108058 12322 18015 59029 19197 19417 19184 19179 22190 20422 171463 14573 667035 19182 16590 240057 19181 231474 64654 80903 14173 23997 14164 66997 18039 218397 110135 14585 14178 80857 228769 14180 70247 67089 14586 14587 14175 21762 14177 23996 20416 11876 14165 26554 18596 109880 16399 54153 15200 640703 18673 12325 16706 69601 83379 22371 73902 233046 114716 12981 19415 63953 14174 12982 19252 16653 12984 240672 13537 12988 67836 16186 13385 14588 211323 16184 11836 18188 20740 20739 13645 16185 16452 216869 109689 18176 18049 72399 70686 18211 114715 240168 14268 66413 211255 18183 14083 16451 19192 16453 26445 19166 18218 14812 76089 26444 26446 14811 26443 14813 19414 80297 14814 16183 20742 20741 21687 20743 16367 13866 14810 16192 26396 14360 16191 216148 114713 14186 19418 22123 20662 19052 14170 19053 19262 73699 640524 16913 75590 19175 19177 51792 19713 19170 22330 99571 13874 103554 16912 54401 83961 16188 19173 19172 21770 26932 107971 226849 100986 18611 23980 26931 20418 225849 320484 384783 245684 67112 110157 19167 26441 19419 11472 19171 545987 13649 70727 18595 26442 26440 101809 18591 12929 18803 107746 CLATHRIN-MEDIATED ENDOCYTOSIS%REACTOME%R-HSA-8856828.1 Clathrin-mediated endocytosis 14269 13543 194590 17113 22418 108679 11772 13645 20616 12402 216869 66616 109689 53330 66147 11771 71770 20955 238055 214459 210108 11555 56378 22320 215114 12757 232910 30948 67602 11773 13430 218038 22319 66713 103967 14366 16835 26895 12000 23970 22318 229521 228998 30931 15463 14725 29816 67300 12492 26754 26893 100017 54609 23969 20980 20508 56017 56085 60510 231580 13649 20979 72685 80708 12504 13858 13854 20404 170625 11607 12500 26891 12638 108800 100043806 15481 55925 13132 11998 106628 320129 12848 16004 13855 13043 21336 20403 233489 19707 218503 56443 243764 22190 11845 667035 66691 20405 20975 19345 12502 18717 104015 19344 18704 13429 22041 269774 20408 76709 22042 110355 16443 320634 73094 26894 73178 30934 68089 74325 74117 271457 67771 18002 74015 26572 TFAP2A ACTS AS A TRANSCRIPTIONAL REPRESSOR DURING RETINOIC ACID INDUCED CELL DIFFERENTIATION%REACTOME DATABASE ID RELEASE 57%8869496 TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation 18148 21418 15510 110109 17865 KETONE BODY CATABOLISM%REACTOME DATABASE ID RELEASE 57%77108 Ketone body catabolism 67041 110446 71911 RRNA MODIFICATION IN THE NUCLEUS AND CYTOSOL%REACTOME DATABASE ID RELEASE 57%6790901 rRNA modification in the nucleus and cytosol 52705 66138 233802 269470 98956 110109 102462 68327 213895 230082 208144 57315 27966 216987 14113 78394 20115 667739 66254 55989 100608 224823 100040177 67134 18572 21771 68147 67755 59028 217995 213773 100041622 75416 622491 52530 215193 245474 105372 70683 73674 223499 65961 14791 72554 234374 20044 72515 66181 67973 27993 667279 76846 67674 68979 110816 217109 67205 METAL ION SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 57%425410 Metal ion SLC transporters 239436 230810 66500 53945 214922 30791 67547 106947 69048 72002 22782 213053 22784 106957 210148 14977 227059 72027 18173 338365 18174 12870 15203 98396 20529 ACTIVATION OF NF-KAPPAB IN B CELLS%REACTOME%R-HSA-1169091.1 Activation of NF-kappaB in B cells 108723 19186 19188 18751 57296 67151 66413 19185 66998 53380 12042 19192 26445 17463 19166 69077 26444 12234 26446 26443 26965 18037 19696 22123 59029 19184 19179 22190 20422 26409 667035 19182 19181 23997 66997 21402 240354 16913 228769 70247 19175 19177 67089 103583 19170 21762 23996 103554 16912 19173 19172 12675 19697 18033 73902 18036 19167 18035 26441 16151 16150 19171 26442 26440 VIRAL MRNA TRANSLATION%REACTOME DATABASE ID RELEASE 57%192823 Viral mRNA Translation 76808 68028 100043755 19899 67186 20115 57294 667739 67025 27370 65019 67248 666669 100038991 100038875 100040021 100037258 432502 66481 100040298 238217 56040 667618 19989 67891 100042986 100042740 621100 100043295 67097 100043000 625646 67281 633683 666899 667035 16785 100039316 267019 100040970 19941 382492 20055 19951 100042670 68193 665189 668182 19921 20044 668144 100043423 100043893 670832 100043876 629957 225058 22121 75617 667279 76846 27050 100043184 19934 231413 100040331 100043391 319195 68172 241053 100043209 20102 67941 27207 668668 20103 672214 622534 20085 20084 INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS%REACTOME DATABASE ID RELEASE 57%176033 Interactions of Vpr with host cellular proteins 218210 66679 18226 69912 227720 11740 54563 223921 103468 70699 433923 72787 269113 231042 234865 69736 19069 107939 16646 170762 15361 59015 227699 18141 11739 445007 108989 19386 101739 69482 71805 23825 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%R-HSA-2197563.1 NOTCH2 intracellular domain regulates transcription 270118 14128 19664 15208 328572 433586 15205 12912 18129 333639 103806 14939 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD%REACTOME DATABASE ID RELEASE 57%3359473 Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD 109129 67096 ACTIVATION OF BMF AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%R-HSA-139910.1 Activation of BMF and translocation to mitochondria 68097 26419 171543 RELEASE OF APOPTOTIC FACTORS FROM THE MITOCHONDRIA%REACTOME DATABASE ID RELEASE 57%111457 Release of apoptotic factors from the mitochondria 670717 66593 CRMPS IN SEMA3A SIGNALING%REACTOME%R-HSA-399956.1 CRMPs in Sema3A signaling 12569 18186 243743 18846 56637 12933 18845 22240 26757 65254 20346 12568 12934 14360 14159 18844 ADHERENS JUNCTIONS INTERACTIONS%REACTOME%R-HSA-418990.2 Adherens junctions interactions 16480 12557 12554 11727 12388 12560 239857 12565 12552 320873 12555 241201 12558 12561 12550 12385 94332 58235 239096 58998 12564 71740 19294 12562 12563 54725 215654 O2 CO2 EXCHANGE IN ERYTHROCYTES%REACTOME DATABASE ID RELEASE 57%1480926 O2 CO2 exchange in erythrocytes 230582 12349 266690 320635 12351 72017 20533 11826 15122 15129 12346 19743 DEFECTS IN VITAMIN AND COFACTOR METABOLISM%REACTOME DATABASE ID RELEASE 57%3296482 Defects in vitamin and cofactor metabolism 100705 17850 110821 72039 66904 109136 78038 54219 109129 238505 67096 210009 14603 93835 21452 65969 107476 18563 HCN CHANNELS%REACTOME DATABASE ID RELEASE 57%1296061 HCN channels 15166 330953 15168 15165 OXYGEN-DEPENDENT ASPARAGINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA%REACTOME DATABASE ID RELEASE 57%1234162 Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha 13819 15251 319594 NGF-INDEPENDANT TRKA ACTIVATION%REACTOME%R-HSA-187024.1 NGF-independant TRKA activation 11517 18211 18212 11516 11540 CRNA SYNTHESIS%REACTOME%R-HSA-192869.1 cRNA Synthesis G2 M DNA DAMAGE CHECKPOINT%REACTOME%R-HSA-69473.3 G2 M DNA damage checkpoint 17535 69263 12021 19718 22390 319181 19891 100039786 68240 70620 15204 70681 240087 12189 11920 231724 382522 237911 70238 210766 55948 327762 27223 21975 22059 19355 22631 22629 22628 20184 19367 72151 106344 12534 59004 22427 68275 19356 12144 235559 319183 319182 319178 319186 319190 107823 93765 22627 54401 19360 235610 107976 319152 68251 81601 225182 27354 15574 50883 12532 319188 15270 26909 12649 78303 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES%REACTOME%R-HSA-1834941.1 STING mediated induction of host immune responses 17535 268857 56480 22040 446099 20821 72935 214763 72512 207521 54131 22596 19090 14375 20852 58203 HYALURONAN UPTAKE AND DEGRADATION%REACTOME%R-HSA-2160916.2 Hyaluronan uptake and degradation 15587 12505 15366 15212 109685 15211 20544 56398 114332 15586 192188 110006 MAPK3 (ERK1) ACTIVATION%REACTOME%R-HSA-110056.1 MAPK3 (ERK1) activation 16194 16193 12534 19247 26395 54721 16451 26417 16452 INFLUENZA INFECTION%REACTOME DATABASE ID RELEASE 57%168254 Influenza Infection 16646 76808 68028 100043755 19899 67186 20115 57294 667739 67025 12757 27370 65019 67248 666669 100038991 100038875 15519 100040021 54196 432502 66481 100040298 238217 56040 667618 19989 67300 21803 103573 19384 218210 66679 100039592 18226 67710 69912 17749 66420 245841 227720 54563 11740 223921 103468 70699 16211 20021 16648 69241 72787 16649 269113 231042 234865 69736 19069 107939 170762 193740 59015 227699 69833 18141 100037258 68705 54188 20022 69920 445007 231329 98053 12317 108989 19386 100043714 20020 69482 71805 67891 100042986 100042740 621100 100043295 67097 100038882 100043000 625646 67281 633683 667035 666899 16785 100039316 267019 100040970 12330 19941 382492 20055 19951 100042670 68193 665189 668182 19921 20044 668144 100043423 100043893 670832 100043876 629957 225058 22121 75617 667279 76846 27050 100043184 19934 231413 100040331 100043391 319195 68172 241053 100043209 20102 19106 67941 381686 27207 70572 668668 20103 672214 622534 20085 20084 MAP3K8 (TPL2)-DEPENDENT MAPK1 3 ACTIVATION%REACTOME%R-HSA-5684264.1 MAP3K8 (TPL2)-dependent MAPK1 3 activation 12234 26965 22190 26395 26398 667035 12675 18033 231130 16151 16150 21402 26410 103583 APOPTOTIC EXECUTION PHASE%REACTOME DATABASE ID RELEASE 57%75153 Apoptotic execution phase 12368 12369 19877 12367 227753 18753 21873 14272 434174 13511 20740 97165 13368 13347 12370 27061 16211 11797 223255 20230 13510 12169 109620 18772 13512 14957 56702 14083 18810 16906 14453 21872 70415 13169 56215 22352 12550 16646 14958 11789 80838 50708 18761 50709 74006 269582 11518 224105 G-PROTEIN MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 57%112040 G-protein mediated events 18750 18796 18573 19088 18795 18753 224129 11513 11512 11515 11514 18752 104110 229709 12326 14678 14677 14679 16440 18798 18797 110355 18747 18574 16438 18749 210044 18575 432530 18783 104111 12912 640703 26413 19087 19085 19084 242851 14681 14685 14686 14687 16439 14680 RNA POLYMERASE III TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 57%73980 RNA Polymerase III Transcription Termination 17749 66420 245841 20016 26939 69833 70408 18029 67486 12909 18032 78929 20018 67065 67005 20823 18027 100043714 218832 69870 70428 74414 ETHANOL OXIDATION%REACTOME%R-HSA-71384.2 Ethanol oxidation 11668 60525 26876 11532 68738 11522 11529 72535 11669 APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS%REACTOME DATABASE ID RELEASE 57%351906 Apoptotic cleavage of cell adhesion proteins 109620 18772 13512 12367 21873 13511 21872 12550 13510 CLEARANCE OF NUCLEAR ENVELOPE MEMBRANES FROM CHROMATIN%REACTOME DATABASE ID RELEASE 57%2993913 Clearance of Nuclear Envelope Membranes from Chromatin 22367 380664 224640 13726 23825 IRS ACTIVATION%REACTOME DATABASE ID RELEASE 57%74713 IRS activation 16334 16367 14783 16337 384783 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM%REACTOME DATABASE ID RELEASE 57%72202 Transport of Mature Transcript to Cytoplasm 218210 193116 66679 107829 18226 110809 225027 69912 60365 331401 66511 68278 227720 54563 223921 19826 103468 67996 70699 73666 20382 72787 53817 51786 71713 70579 66231 69823 233073 73826 56488 69207 108014 269113 231042 386612 234865 69736 17149 94230 19069 100040029 107939 170762 192160 625193 59015 225160 227699 20492 68092 66441 18141 54451 54188 433702 64340 192170 445007 66899 622469 51796 108989 19386 21681 20383 69482 68134 71805 13684 53319 G ALPHA (12 13) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 57%416482 G alpha (12 13) signalling events 54126 545156 14706 14696 18710 224014 269608 101497 14688 13605 14708 14693 75547 14709 26382 16800 16801 14697 57257 22325 18709 11548 11549 11550 19418 19877 19353 11848 236915 19878 20662 56212 19354 11852 71704 213498 102098 16443 277360 14699 66066 226970 21390 207212 14700 20663 14701 11853 73341 14674 56349 18708 14695 18706 171207 14704 24001 14702 223435 14710 109904 64337 22324 235611 109934 14673 69632 30938 21844 17207 230972 213649 53972 14163 PAOS OXIDISE POLYAMINES TO AMINES%REACTOME DATABASE ID RELEASE 57%141334 PAOs oxidise polyamines to amines 212503 INSULIN-LIKE GROWTH FACTOR-2 MRNA BINDING PROTEINS (IGF2BPS IMPS VICKZS) BIND RNA%REACTOME DATABASE ID RELEASE 57%428359 Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs IMPs VICKZs) bind RNA 140486 319765 140488 FGFR3 LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 57%190239 FGFR3 ligand binding and activation 64654 80903 14173 14164 14425 14172 80857 14180 14175 ATTACHMENT OF GPI ANCHOR TO UPAR%REACTOME DATABASE ID RELEASE 57%162791 Attachment of GPI anchor to uPAR 18793 329777 276846 78928 228812 14731 241062 NOTCH-HLH TRANSCRIPTION PATHWAY%REACTOME%R-HSA-350054.1 Notch-HLH transcription pathway 18519 270118 19664 12914 14534 433586 18131 18129 333639 18128 103806 18132 CHROMATIN ORGANIZATION%REACTOME%R-HSA-4839726.2 Chromatin organization 13486 18519 72195 217031 77853 228829 74026 217127 77766 67773 230233 107932 75565 18505 228714 382207 76901 66233 269424 216848 76719 20587 71777 20588 208146 15353 140858 226976 214572 21427 83796 54351 66923 69612 68094 58523 83797 73247 223527 74195 56790 78656 83766 107435 23942 239985 27878 99890 13831 77044 28019 109115 72341 66423 67155 57376 93760 76804 99982 22289 225876 20591 18676 77035 338523 20592 71371 320595 214899 277250 244694 104263 107817 30841 11909 19646 73251 381022 234135 75410 52690 213389 66310 21372 54343 64707 69726 239122 18193 84505 214162 217864 235626 231051 213464 208043 233904 208266 23808 14013 70673 225895 56397 108946 217588 17692 21761 102162 216850 100041953 319181 50724 234366 268936 382522 170787 269003 433759 70315 94246 226830 246103 11569 56456 60406 100683 229542 319183 20185 20602 319182 193796 230674 319178 67956 319186 319190 78783 107823 319162 71954 81601 17192 59035 218214 319188 15270 78303 13626 66464 16452 66262 108155 108143 75560 64050 15182 216185 56310 75605 19712 70465 107392 238247 27374 245688 15161 116870 12914 328572 56505 70088 20174 12567 12443 20586 66993 12753 116871 319169 14056 621893 216825 232440 319189 93871 20937 101206 319176 77683 319173 17978 624153 15469 51788 15077 13435 319149 17977 52615 15267 110147 11461 81004 18599 18600 18602 18601 242726 14534 319163 319168 15183 319167 244349 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME%R-HSA-372708.1 p130Cas linkage to MAPK signaling for integrins 16416 54519 12927 16399 21894 109905 22371 14161 14268 215449 110135 12928 14083 99571 BASE-EXCISION REPAIR, AP SITE FORMATION%REACTOME DATABASE ID RELEASE 57%73929 Base-Excision Repair, AP Site Formation 70603 382913 17193 71726 18207 18294 72774 268395 INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION%REACTOME DATABASE ID RELEASE 57%168273 Influenza Viral RNA Transcription and Replication 76808 68028 100043755 19899 67186 20115 57294 667739 67025 27370 65019 67248 666669 100038991 100038875 100040021 15519 432502 66481 100040298 238217 56040 667618 19989 218210 66679 18226 67710 69912 17749 66420 245841 227720 54563 223921 103468 70699 20021 69241 72787 269113 231042 234865 69736 19069 107939 170762 59015 227699 69833 18141 100037258 68705 20022 69920 445007 231329 98053 108989 19386 100043714 20020 69482 71805 67891 100042986 100042740 621100 100043295 67097 100043000 625646 67281 633683 666899 667035 16785 100039316 267019 100040970 19941 382492 20055 19951 100042670 68193 665189 668182 19921 20044 668144 100043423 100043893 670832 100043876 629957 225058 22121 75617 667279 76846 27050 100043184 19934 100040331 231413 100043391 319195 68172 241053 100043209 20102 67941 27207 70572 668668 20103 672214 622534 20085 20084 LOCALIZATION OF THE PINCH-ILK-PARVIN COMPLEX TO FOCAL ADHESIONS%REACTOME DATABASE ID RELEASE 57%446343 Localization of the PINCH-ILK-PARVIN complex to focal adhesions 57342 16202 19303 16412 KINESINS%REACTOME%R-HSA-983189.2 Kinesins 16581 16554 209737 16563 16565 16560 16571 16573 16579 16564 668303 269152 74947 16569 16562 71819 75050 240641 16580 73470 16578 232943 16568 16552 70218 16570 16572 73804 74764 228421 26934 110033 286942 319991 229841 16558 16593 16594 19348 16561 16551 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION)%REACTOME%R-HSA-198725.1 Nuclear Events (kinase and transcription factor activation) 110651 26416 17260 13712 17164 21770 72349 20111 12912 26417 26413 23939 20112 67603 19052 100040260 19053 319520 73699 73086 19094 17258 51792 235584 ALKBH3 MEDIATED REVERSAL OF ALKYLATION DAMAGE%REACTOME%R-HSA-112126.1 ALKBH3 mediated reversal of alkylation damage 69113 69090 77987 75452 PTK6 REGULATES PROTEINS INVOLVED IN RNA PROCESSING%REACTOME DATABASE ID RELEASE 57%8849468 PTK6 Regulates Proteins Involved in RNA Processing 20459 13992 20218 71514 170771 TRANSCRIPTIONAL REGULATION BY TP53%REACTOME DATABASE ID RELEASE 57%3700989 Transcriptional Regulation by TP53 69263 228829 19718 219022 107932 18538 19891 68240 216848 77976 18983 20878 23942 219103 13000 72151 106344 100039026 17165 68275 53376 11909 16476 66214 19646 60599 14751 78893 12447 216456 22627 14660 64930 12122 18861 17350 17685 66096 12142 53325 12177 54170 245670 68576 407786 14281 20869 75747 68441 26909 66508 52187 105787 68428 17535 59092 12021 13197 100039786 13163 234366 268936 240087 319801 12189 17248 12568 11920 231724 83409 237911 55948 327762 12448 21975 433759 22059 19355 12450 22631 22629 22628 58184 18997 18996 226830 19367 107986 12534 12566 230784 22427 19356 241764 69131 12144 29813 235559 15258 229542 22166 13001 22190 67956 667035 12427 78783 234594 52679 12227 268973 19352 71361 19364 19360 23988 56187 235610 66813 81601 17192 59035 225182 382985 27354 15574 50883 74747 12532 252870 18477 12649 12428 231464 11783 64058 69181 68776 66464 208836 26992 209361 66467 15257 20833 66262 99730 333654 319944 20620 24074 108143 270627 20924 20922 66494 69562 14884 14776 228140 228980 67338 11799 12576 12578 211586 19651 80751 18854 670717 19650 12868 15182 12572 12575 216185 17420 13555 21781 12905 27374 12662 104625 245688 12569 17992 17710 107951 12914 21374 17709 12454 328572 114741 70207 24116 21933 14102 20463 225655 231430 52892 17708 70088 19052 12861 19053 12857 73699 110323 13496 20930 104394 100041785 51792 66142 66379 66671 12858 72416 53621 108079 241113 66359 232791 26416 72068 54401 76367 23894 57314 27632 226182 12795 26931 13871 13872 58202 209357 12053 14885 52846 13716 72504 67655 21343 545987 67923 27224 72949 12455 66272 21399 69802 22062 69125 21981 76850 67710 17749 236511 66420 245841 20021 69241 12028 108099 57748 19079 108097 19094 19082 16009 209456 68742 22061 77683 69076 74370 20877 15469 69833 68705 20022 69920 14088 231329 211651 98053 100043714 20020 12368 56717 22084 110147 72119 239528 12362 57913 213988 21672 11652 12366 20393 11651 17988 78757 217351 244349 233833 23797 17246 56716 214150 18148 18607 50493 19211 227743 109270 14381 17454 INITIATION OF NUCLEAR ENVELOPE REFORMATION%REACTOME DATABASE ID RELEASE 57%2995383 Initiation of Nuclear Envelope Reformation 19052 71978 71782 16906 22367 51792 380664 224640 13726 23825 CELLULAR RESPONSE TO HYPOXIA%REACTOME DATABASE ID RELEASE 57%2262749 Cellular response to hypoxia 11863 13819 22346 12914 71745 230099 112406 53417 112407 328572 15251 22190 22339 13856 17684 667035 100041766 216080 66105 56438 67923 319594 SHC-MEDIATED CASCADE:FGFR1%REACTOME%R-HSA-5654688.1 SHC-mediated cascade:FGFR1 14165 18176 64654 67112 20662 14173 14164 14174 80857 14180 16653 15461 14175 14177 ACYL CHAIN REMODELLING OF PI%REACTOME%R-HSA-1482922.2 Acyl chain remodelling of PI 26971 18784 78390 18783 77582 66857 232889 18779 225845 18782 66350 329502 18778 271844 26970 26565 DIGESTION OF DIETARY LIPID%REACTOME%R-HSA-192456.3 Digestion of dietary lipid 109791 239759 76483 18946 69060 15450 67717 70166 12613 18947 240633 105847 16891 LIGAND-GATED ION CHANNEL TRANSPORT%REACTOME%R-HSA-975298.1 Ligand-gated ion channel transport 14401 14402 110304 14408 15561 14407 14400 236915 57249 14406 14395 14658 328699 14657 14654 14409 14394 237213 14397 14399 110886 57014 14396 PRC2 METHYLATES HISTONES AND DNA%REACTOME DATABASE ID RELEASE 57%212300 PRC2 methylates histones and DNA 14056 52615 15267 319183 13626 19646 21652 319181 319182 319178 319186 319190 232440 319168 382522 319167 319176 13433 16468 11569 624153 13436 625328 51788 15077 13435 319188 15270 319149 78303 245688 319169 17765 74016 IRAK4 DEFICIENCY (TLR5)%REACTOME%R-HSA-5603037.1 IRAK4 deficiency (TLR5) 266632 53791 17874 CELL DIVISION%REACTOME%R-HSA-68884.1 cell division 24061 71175 20843 13006 18817 74549 19357 218914 20842 18221 71819 71521 19348 100710 FGFR2 LIGAND BINDING AND ACTIVATION%REACTOME%R-HSA-190241.1 FGFR2 ligand binding and activation 14165 64654 67112 14173 80903 14164 14174 14178 14172 80857 14181 14180 72514 14175 14177 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS%REACTOME%R-HSA-168643.1 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways 54483 195046 11797 29857 11796 19094 216799 55991 257632 18439 22166 74256 107607 66824 383619 332579 108960 26415 26409 19200 12362 12370 12371 192656 21929 56338 15516 68652 66724 11820 12363 22034 16396 66513 12366 93765 268973 26416 12043 12048 12675 19697 18033 26399 16151 18034 16150 67955 66589 16179 SUMO IS CONJUGATED TO E1 (UBA2:SAE1)%REACTOME DATABASE ID RELEASE 57%3065676 SUMO is conjugated to E1 (UBA2:SAE1) 50995 56459 100043429 20610 2-LTR CIRCLE FORMATION%REACTOME DATABASE ID RELEASE 57%164843 2-LTR circle formation 15361 108138 22596 319583 14375 101739 23825 SIGNALING BY FGFR1 IN DISEASE%REACTOME%R-HSA-5655302.2 Signaling by FGFR1 in disease 327826 18803 18176 20662 64654 14173 14164 67529 20848 80857 14180 15461 432508 20846 13047 14175 14177 21848 67384 20851 360013 20850 14389 76007 18708 18706 75296 110279 14182 244373 14388 16653 LYSOSOMAL GLYCOGEN CATABOLISM%REACTOME DATABASE ID RELEASE 57%5357572 Lysosomal glycogen catabolism 14387 27357 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS%REACTOME DATABASE ID RELEASE 57%163125 Post-translational modification: synthesis of GPI-anchored proteins 68563 55981 433931 329777 27392 67292 276846 668145 56703 18700 78928 13481 14731 241062 13480 72084 230801 110417 18793 327942 70325 18701 228812 67556 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS%REACTOME%R-HSA-450531.3 Regulation of mRNA stability by proteins that bind AU-rich elements 18750 18753 227720 19186 19188 57296 27998 67151 15568 22695 19094 66413 66362 19185 66998 53380 19192 15507 26445 17463 19166 69077 227715 50911 26444 26446 17164 12192 75901 26443 193740 15481 22631 72544 24127 66446 208643 69583 109075 18458 70640 22123 11737 59029 19184 19179 22190 20422 667035 19182 72662 74108 19181 23997 66997 671392 69639 238799 66583 11651 16913 228769 19175 70247 19177 67089 19170 21762 23996 103554 26416 16912 54401 19173 19172 103573 73902 19167 26441 19171 26442 26440 VPU MEDIATED DEGRADATION OF CD4%REACTOME DATABASE ID RELEASE 57%180534 Vpu mediated degradation of CD4 12504 19186 19188 57296 67151 66413 19185 66998 53380 19192 17463 26445 19166 69077 26444 26446 12234 26443 22123 59029 19184 22190 19179 20422 667035 19182 19181 23997 66997 21402 16913 228769 19175 70247 67089 19177 19170 21762 23996 103554 16912 19173 19172 73902 19167 26441 19171 26442 26440 ENZYMATIC DEGRADATION OF DOPAMINE BY MONOAMINE OXIDASE%REACTOME DATABASE ID RELEASE 57%379398 Enzymatic degradation of Dopamine by monoamine oxidase 17161 12846 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 57%352230 Amino acid transport across the plasma membrane 11989 215113 53896 72401 246049 20532 26570 74338 14411 215335 67760 21366 20514 50934 30962 103098 102680 22598 105727 69354 56774 330836 20540 55963 17254 209837 11987 76257 20539 CHREBP ACTIVATES METABOLIC GENE EXPRESSION%REACTOME DATABASE ID RELEASE 57%163765 ChREBP activates metabolic gene expression 100705 55979 14104 107476 104112 21428 58805 AURKA ACTIVATION BY TPX2%REACTOME DATABASE ID RELEASE 57%8854518 AURKA Activation by TPX2 19088 76816 18817 56455 76478 71909 219072 214552 237222 20873 18536 104318 22145 73738 20878 26370 74470 219103 17997 99100 74360 68121 18472 27373 12009 13589 54130 76707 230376 22628 66296 236266 78887 18005 15519 381644 22154 225745 12534 214444 28135 231123 13427 13424 83922 208518 75786 18541 103733 101565 78177 69654 22153 225659 72119 227613 16328 53598 22142 68475 22627 51792 18747 100986 75296 15366 REGULATION OF GENE EXPRESSION IN BETA CELLS%REACTOME DATABASE ID RELEASE 57%210745 Regulation of gene expression in beta cells 16334 30942 18609 18096 23797 56458 103988 11652 20526 18088 18508 11651 15377 378435 18012 21405 15874 15376 VRNA SYNTHESIS%REACTOME DATABASE ID RELEASE 57%192814 vRNA Synthesis SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI)%REACTOME DATABASE ID RELEASE 57%162710 Synthesis of glycosylphosphatidylinositol (GPI) 55981 433931 27392 67292 668145 56703 18700 13481 72084 230801 110417 327942 70325 18701 67556 HOST INTERACTIONS OF HIV FACTORS%REACTOME DATABASE ID RELEASE 57%162909 Host Interactions of HIV factors 11772 252903 11840 11771 71770 66413 100088 12010 19192 26445 19166 16646 15361 26444 26446 26443 232910 11773 15007 56438 14360 224105 22123 268373 107951 19353 19385 21402 16913 19175 19177 19170 103554 16912 19173 19172 103573 19167 26441 19171 67923 26442 101739 26440 19384 12455 23825 75717 218210 66679 18226 69912 12504 227720 108664 54563 11740 223921 19186 94176 103468 19188 70699 16211 433923 72787 57296 67151 19185 66998 53380 269113 231042 234865 17463 69736 19069 69077 107939 170762 12234 108012 11768 11767 59015 227699 18141 445007 108989 19386 11765 69482 11764 71805 140580 59029 19184 22190 19179 20422 667035 19182 19181 23997 66997 228769 70247 67089 12487 21762 23996 15162 11769 16818 18148 73902 11739 107975 12526 SENSING OF DNA DOUBLE STRAND BREAKS%REACTOME DATABASE ID RELEASE 57%5693548 Sensing of DNA Double Strand Breaks 27354 100039592 17535 19360 11920 81601 ACTIVATION OF ANTERIOR HOX GENES IN HINDBRAIN DEVELOPMENT DURING EARLY EMBRYOGENESIS%REACTOME DATABASE ID RELEASE 57%5617472 Activation of anterior HOX genes in hindbrain development during early embryogenesis 14056 56406 67710 13626 17749 66420 245841 319181 20021 232440 69241 140858 382522 319176 13654 22632 17979 58184 22658 22289 624153 69833 625328 51788 20022 15077 69920 18508 231329 319149 104625 20181 100043714 245688 20020 15412 15400 52615 15401 12914 15267 13018 16476 16475 319183 17268 218772 19646 20185 15394 328572 17344 19401 67278 15399 319182 15436 19411 319178 15434 319186 55982 16658 319190 15429 18771 381022 18514 319168 15183 319167 231051 213464 23808 15423 319188 15270 319169 78303 15407 15410 103889 329559 CELL CYCLE%REACTOME DATABASE ID RELEASE 57%1640170 Cell Cycle 18973 19687 69263 67967 19718 76816 18972 18817 22367 18538 67629 19891 74549 69745 14245 68240 69928 18971 105988 70099 77744 56455 76478 71909 219072 214552 237222 20873 18536 104318 22145 73738 20878 26370 74470 219103 17997 52683 99100 236930 74360 68014 68121 71175 18472 66352 27373 208628 12009 57294 382030 13589 68298 54130 52696 76707 67849 230376 67733 66296 83815 236266 102920 78887 76464 18005 218914 19046 66570 83431 59001 381644 13000 72151 22154 67181 106344 225745 100039026 214444 28135 108911 76499 66979 231123 18221 18974 13427 12617 13424 52432 68275 83922 215387 208518 70231 75786 76044 18541 26886 103733 66934 101565 224640 78177 13726 17274 69654 22153 225659 71648 16475 227613 17931 16328 53598 22142 68475 213389 93765 103583 17350 13404 55993 19183 217716 76915 17687 26972 26909 104271 19186 19188 57296 67151 19185 66998 53380 17463 69077 12234 433759 13006 26413 497652 21749 28113 101185 20842 57321 320394 226747 78658 66442 12615 59029 72155 108000 14211 19184 13001 19179 21750 60411 20422 625534 67956 232987 19182 66468 56205 59021 19181 67052 52504 64898 23997 217718 66997 671392 67139 67121 59125 71782 71521 228769 70385 70247 71876 67089 59126 100710 59046 21762 70454 23996 73902 64899 244495 381318 66336 244329 67037 216965 72415 56430 380664 30939 66977 12235 26951 66413 19192 26445 19166 26444 26446 26443 229776 19047 19348 22123 20459 16913 19175 19177 19170 103554 16912 54401 73804 19173 19172 100986 103573 19167 26441 19171 229841 26442 26440 23825 18750 19088 232440 15512 624153 625328 51788 15077 319149 18969 19075 16906 18747 12190 67177 114714 67141 20135 17246 13361 18148 18968 19076 217653 70645 66578 15519 74498 19646 56371 71988 77805 13548 12447 50793 22627 103768 51885 75660 66311 20892 100038822 233532 629959 74237 15366 231506 259279 12537 101706 56299 72568 21664 233276 70024 66156 17535 59092 12021 52206 16563 668450 22390 319181 12237 22194 100039786 56150 70620 75430 216080 15204 70681 240087 27214 12189 19324 17248 21973 26374 11920 52717 71819 18392 26428 18393 26429 231724 382522 237911 70238 210766 55948 327762 27223 12448 21975 22059 19355 22631 22629 22628 52563 99152 19357 20184 19367 12544 12545 12534 12566 269582 59004 22427 16319 69957 12442 19356 68999 12144 68612 29813 235559 17222 99412 76308 319183 22190 12236 319182 319178 667035 319186 319190 12427 268930 107823 73470 17215 17219 17217 17120 29870 56452 19360 66634 235610 107976 319152 68251 81601 75296 59008 56317 228421 225182 27354 19361 15574 50883 23834 107995 12532 12530 217232 319188 17216 15270 12649 78303 17220 12428 17218 57813 22171 94244 74075 77053 93762 50878 12579 11799 71846 12576 64009 12578 17187 20962 71978 319565 211586 20957 19651 320558 19650 66654 26965 12571 13557 12572 19645 223697 12575 56739 17420 140557 13555 75459 21781 27401 242705 245688 328572 56505 57441 52530 245474 216853 20174 19052 19053 73699 21752 100043858 21402 12580 12567 13559 12443 104394 51792 12444 17869 66671 54124 12445 21770 26932 226849 26931 225849 319169 218210 66679 18226 69912 227720 54563 223921 103468 70699 14235 72787 18751 269113 231042 234865 69736 19069 107939 319176 170762 52276 16881 14156 56041 59015 20877 12531 227699 18141 445007 109145 272551 108989 78833 19386 69270 69482 71805 110379 15267 72119 15516 319168 319167 24061 22196 20843 17865 BINDING AND ENTRY OF HIV VIRION%REACTOME%R-HSA-173107.1 Binding and entry of HIV virion 268373 12767 12774 12504 REGULATION OF GENE EXPRESSION IN ENDOCRINE-COMMITTED (NEUROG3+) PROGENITOR CELLS%REACTOME DATABASE ID RELEASE 57%210746 Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells 18088 53626 11925 18506 18012 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER%REACTOME%R-HSA-2894858.1 Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 18519 11487 56233 11491 333639 59287 54485 13388 16450 16449 433586 103806 79221 170787 225164 208727 15208 240055 433759 15205 26965 15213 15182 76580 15185 232232 70315 56198 15214 264064 15184 56438 12914 20185 328572 20602 22190 18011 667035 81004 14534 21402 21372 17869 15183 51813 270118 208117 19165 19664 100039623 100042305 18128 THE IPAF INFLAMMASOME%REACTOME DATABASE ID RELEASE 57%844623 The IPAF inflammasome 12362 268973 FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 57%6783310 Fanconi Anemia Pathway 67513 60534 208836 22190 55947 667035 19891 101831 69928 68240 237211 100040608 58206 52864 268465 50505 13870 330554 235610 272158 20892 71711 71885 67196 104806 230484 14088 68275 211651 140917 72775 14087 67030 BUDDING AND MATURATION OF HIV VIRION%REACTOME DATABASE ID RELEASE 57%162588 Budding and maturation of HIV virion 52348 194309 268373 66700 66914 330192 22088 20479 83814 22190 116733 107305 667035 68953 105513 18571 208092 66371 75608 66201 76959 NETRIN MEDIATED REPULSION SIGNALS%REACTOME DATABASE ID RELEASE 57%418886 Netrin mediated repulsion signals 13176 107448 19247 14083 18208 14360 210801 22253 107449 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION%REACTOME DATABASE ID RELEASE 57%749476 RNA Polymerase III Abortive And Retractive Initiation 17749 21374 66420 245841 20841 20016 26939 70408 67486 18029 12909 18032 78929 20018 67065 67005 20823 18027 218832 69870 70428 74414 233863 227644 544971 75627 66596 102209 77634 71752 72308 330959 69833 66653 70239 269252 67371 100043714 98488 18986 INTERLEUKIN-7 SIGNALING%REACTOME%R-HSA-1266695.3 Interleukin-7 signaling 16186 20851 20850 19374 16197 18708 19373 18709 18710 15077 16196 16451 93871 319149 15234 16453 20586 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR%REACTOME%R-HSA-442982.1 Ras activation uopn Ca2+ infux through NMDA receptor 12323 13385 14812 108058 12322 19417 14811 14813 100986 640703 12325 14814 18039 11472 14810 15461 19418 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC)%REACTOME DATABASE ID RELEASE 57%975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 60365 19826 17149 76808 68028 100043755 19899 71978 67186 20115 57294 667739 192160 67025 27370 65019 67248 666669 100038991 100038875 100040021 66441 192170 432502 66481 100040298 238217 56040 68134 667618 19989 103677 19052 51792 71997 226517 229512 74133 14852 68092 225363 19704 433702 208643 326622 14853 67031 18458 67891 100042986 100042740 621100 100043295 67097 100043000 625646 67281 633683 233789 667035 666899 16785 100039316 267019 100040970 19941 382492 20055 19951 100042670 68193 665189 668182 19921 20044 668144 100043423 100043893 670832 100043876 629957 225058 22121 75617 667279 76846 27050 100043184 19934 100040331 100043391 319195 68172 241053 100043209 20102 67941 27207 668668 20103 672214 622534 20085 20084 RHO GTPASES ACTIVATE ROCKS%REACTOME DATABASE ID RELEASE 57%5627117 RHO GTPases Activate ROCKs 19877 11853 17931 11848 16885 71960 19878 16886 19046 67938 17886 17880 329251 77579 67268 11852 17904 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B%REACTOME DATABASE ID RELEASE 57%174048 APC C:Cdc20 mediated degradation of Cyclin B 66156 52206 668450 22190 22194 667035 52563 59008 99152 56317 75430 216080 12534 107995 69957 217232 52717 68999 68612 17222 ACTIVATION OF PUMA AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%R-HSA-139915.3 Activation of PUMA and translocation to mitochondria 22062 21981 22059 209456 13555 22061 21781 S37 MUTANTS OF BETA-CATENIN AREN'T PHOSPHORYLATED%REACTOME DATABASE ID RELEASE 57%5358749 S37 mutants of beta-catenin aren't phosphorylated 11789 56637 93687 72345 21770 26932 226849 12387 12005 26931 225849 19052 19053 73699 51792 REGULATION OF IGF ACTIVITY BY IGFBP%REACTOME%R-HSA-381426.1 Regulation of IGF Activity by IGFBP 16008 16011 16012 17390 83995 13035 14943 16000 16002 18815 23850 16010 626834 14061 16005 16009 18491 16006 DEFECTIVE CHSY1 CAUSES TPBS%REACTOME DATABASE ID RELEASE 57%3595177 Defective CHSY1 causes TPBS 121021 13003 12032 13004 12111 29873 13179 TWIK-RELATED ALKALINE PH ACTIVATED K+ CHANNEL (TALK)%REACTOME%R-HSA-1299361.1 TWIK-related alkaline pH activated K+ channel (TALK) 74571 THE ROLE OF GTSE1 IN G2 M PROGRESSION AFTER G2 CHECKPOINT%REACTOME%R-HSA-8852276.1 The role of GTSE1 in G2 M progression after G2 checkpoint 18817 19186 19188 57296 67151 66413 19185 66998 53380 19192 17463 26445 19166 69077 26444 26446 22059 13589 26443 12575 15519 12534 12442 22123 59029 19184 19179 22190 20422 667035 19182 19181 15516 23997 66997 16913 228769 70247 19175 67089 19177 19170 21762 23996 103554 16912 29870 19173 19172 73902 19167 26441 19171 26442 56299 26440 COSTIMULATION BY THE CD28 FAMILY%REACTOME DATABASE ID RELEASE 57%388841 Costimulation by the CD28 family 53859 12504 19247 75778 12519 12524 12500 18710 60533 15170 17096 17444 18709 50723 18481 14960 14968 14360 14969 224105 58205 18566 56717 19353 208154 19052 19053 73699 11652 12502 12501 11651 22612 18479 78757 228775 51792 12487 18708 23797 21770 26932 18706 226849 230979 16818 26931 56716 225849 18607 12477 22324 227743 26410 109270 12988 PHOSPHOLIPASE C-MEDIATED CASCADE; FGFR4%REACTOME DATABASE ID RELEASE 57%5654228 Phospholipase C-mediated cascade; FGFR4 18750 18573 19088 18753 224129 18754 11513 11512 11515 11514 18752 104110 229709 18803 64654 14170 80903 14173 14164 12326 80857 14172 16440 14180 110355 18747 14175 18574 14177 16438 18749 210044 18575 432530 104111 12912 640703 83379 19087 19085 19084 14186 16439 LOSS OF FUNCTION OF FBXW7 IN CANCER AND NOTCH1 SIGNALING%REACTOME%R-HSA-2644607.1 Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling 21402 26965 56438 18128 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE%REACTOME%R-HSA-4641262.3 Disassembly of the destruction complex and recruitment of AXIN to the membrane 14296 13543 14367 22423 57265 212398 19052 19053 12389 73699 22416 20890 51792 16974 22408 103236 11789 56637 93687 72345 21770 13542 26932 13544 226849 12387 12005 26931 225849 14362 16973 RETINOID CYCLE DISEASE EVENTS%REACTOME%R-HSA-2453864.2 Retinoid cycle disease events 19659 14539 12057 22139 242864 19662 19771 20897 SIGNALING BY PTK6%REACTOME DATABASE ID RELEASE 57%8848021 Signaling by PTK6 12223 211323 100042150 13645 106766 12402 18176 226525 114715 18183 15461 12702 14815 12576 19414 330662 12566 13866 114713 66725 93695 13819 140580 18015 232906 19353 12927 20459 11848 15251 22190 19303 75273 667035 140579 240057 69710 218397 13448 11651 12928 12567 20848 12447 12443 170771 13874 83961 54153 15200 320484 71514 69601 114716 19415 13649 13992 16653 20218 19246 101809 20811 MAJOR PATHWAY OF RRNA PROCESSING IN THE NUCLEOLUS AND CYTOSOL%REACTOME%R-HSA-6791226.2 Major pathway of rRNA processing in the nucleolus and cytosol 52705 269470 66249 53414 102462 104318 230082 57315 76808 68028 216987 100043755 19899 78394 67186 20115 27373 57294 667739 67025 27370 55989 65019 100608 224823 67248 666669 100038991 100038875 100040021 67134 18572 21771 66878 432502 66481 100040298 238217 56040 67755 667618 19989 217995 67619 213773 75273 215193 71340 69639 66583 68533 65961 72198 67053 227522 67973 269536 54364 64934 216156 12181 102614 104662 27998 76130 66362 80886 213895 229504 208144 227715 27966 50911 14113 72544 66446 100040177 208366 109075 67676 59028 74035 67891 100042986 100042740 24128 621100 100043295 67097 353258 100043000 625646 100041622 67281 75416 622491 633683 50912 666899 667035 16785 100039316 267019 105372 70683 100040970 73674 223499 19941 382492 14791 20055 57316 19951 72554 100042670 68193 665189 668182 234374 19921 20044 668144 100043423 72515 100043893 670832 67045 100043876 629957 27993 225058 22121 75617 667279 76846 27050 100043184 19934 100040331 68979 100043391 319195 110816 68172 241053 57750 100043209 67205 217109 20102 67941 27207 668668 20103 672214 622534 20085 20084 RELAXIN RECEPTORS%REACTOME%R-HSA-444821.1 Relaxin receptors 23919 19773 16336 212108 239336 381489 242093 140498 KANDUTSCH-RUSSELL PATHWAY%REACTOME DATABASE ID RELEASE 57%6807062 Kandutsch-Russell pathway 13360 74754 235293 13595 MTB IRON ASSIMILATION BY CHELATION%REACTOME%R-HSA-1222449.1 Mtb iron assimilation by chelation 17002 CONSTITUTIVE SIGNALING BY ABERRANT PI3K IN CANCER%REACTOME%R-HSA-2219530.1 Constitutive Signaling by Aberrant PI3K in Cancer 12223 211323 100042150 19247 13645 327826 12519 12524 18710 18183 14172 74769 18707 18709 16367 13866 14360 14186 77647 16590 64654 80903 14173 14170 14164 12478 14178 80857 14180 12487 14175 14177 13874 14165 83961 18596 18708 15200 18706 16818 384783 83379 67112 14388 22324 14174 13649 18595 18591 CARGO RECOGNITION FOR CLATHRIN-MEDIATED ENDOCYTOSIS%REACTOME%R-HSA-8856825.1 Cargo recognition for clathrin-mediated endocytosis 13543 194590 12504 17113 22418 13858 108679 13854 11772 13645 20616 12402 216869 109689 53330 66147 11771 71770 11607 12500 20955 26891 12638 238055 108800 210108 100043806 11555 22320 55925 13132 12757 232910 11998 67602 11773 320129 12848 22319 16004 13855 21336 20403 14366 16835 26895 12000 233489 19707 22318 229521 218503 30931 243764 22190 15463 667035 14725 67300 12492 12502 26754 100017 26893 22041 54609 269774 110355 22042 16443 73094 26894 20980 30934 56017 20508 74325 56085 18002 74015 60510 26572 13649 20979 HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME%R-HSA-5693579.1 Homologous DNA Pairing and Strand Exchange 17535 69263 12021 19718 19891 68240 74335 12189 11920 231724 237911 12190 233826 327762 19364 21975 19360 19355 235610 114714 57434 19362 81601 19363 19367 225182 19361 27354 72151 15574 106344 22427 68275 19356 12144 26909 12649 235559 DOWNSTREAM SIGNALING OF ACTIVATED FGFR2%REACTOME DATABASE ID RELEASE 57%5654696 Downstream signaling of activated FGFR2 56438 26395 67603 319520 235584 26403 16416 12223 54519 100042150 21894 11600 19060 19186 19188 327826 17169 194231 109905 14161 226525 57296 67151 215449 18710 19185 66998 53380 14172 17967 15461 17463 83409 69077 29875 12912 26417 26413 12323 108058 12322 18015 59029 19197 19417 19184 19179 22190 20422 171463 14573 667035 19182 16590 240057 19181 231474 64654 80903 14173 23997 14164 66997 18039 218397 110135 14585 14178 80857 228769 14180 70247 67089 14586 14587 14175 21762 14177 23996 20416 11876 14165 26554 18596 109880 16399 18708 54153 15200 640703 18706 18673 12325 16818 16706 69601 83379 22371 73902 233046 114716 12981 19415 63953 14174 12982 19252 16653 12984 240672 13537 12988 67836 16186 13385 14588 211323 16184 11836 18188 20740 20739 13645 16185 16452 216869 109689 18176 72399 70686 114715 240168 14268 66413 211255 18183 14083 16451 19192 16453 26445 19166 18218 12576 14812 76089 26444 26446 14811 26443 14813 19414 80297 14814 12575 74769 16183 20742 18707 18709 20741 21687 20743 16367 13866 14810 16192 26396 14360 16191 216148 114713 14186 19418 22123 20662 19052 14170 19053 19262 73699 640524 16913 75590 19175 19177 51792 19713 19170 22330 99571 13874 103554 16912 54401 83961 56637 16188 19173 19172 21770 107971 26932 100986 226849 18611 23980 20418 26931 320484 225849 384783 12675 245684 67112 110157 19167 26441 19419 11472 19171 545987 13649 70727 18595 26442 26440 101809 18591 18750 19088 16334 76850 18753 18754 236511 19247 16337 75778 15370 18752 104110 229709 12519 12524 606496 244650 18573 12015 56717 22084 224129 77647 11513 11512 239528 11515 11514 12371 98432 117150 18803 56458 56484 213988 12326 11652 18717 12478 11651 15937 16440 78757 228775 12487 110355 18747 18574 16438 18749 217351 210044 18575 432530 233833 23797 104111 67605 18720 17246 56716 18719 214150 108083 19087 19085 18607 19084 14388 22324 19211 227743 18718 109270 17454 16439 58988 BETA-CATENIN INDEPENDENT WNT SIGNALING%REACTOME%R-HSA-3858494.3 Beta-catenin independent WNT signaling 14370 93840 66313 13543 14365 14368 14367 75788 22418 11772 57265 216869 11771 14706 71770 14696 66413 14688 19192 14708 14693 26445 14709 19166 14697 18018 26444 26446 26443 12757 232910 11773 14362 21416 56513 106042 14366 14369 105782 22123 19353 11848 67300 22411 18099 16913 19175 19177 19170 14699 66066 103554 14700 16912 14701 19173 19172 14695 21414 16842 12387 21415 19091 14704 14702 14710 64337 19167 26441 19171 26564 26563 26442 26440 18796 18750 18795 76850 236511 19186 19188 18752 20187 18751 57296 67151 19185 66998 53380 18797 17463 22417 69077 22408 18587 225600 18588 170758 12322 59029 18643 19184 22190 19179 239528 20422 26409 667035 19182 19181 213988 19056 23997 19055 66997 19092 19354 16440 228769 70247 67089 21762 23996 16438 217351 208846 74325 233833 13542 640703 13544 214150 19058 73902 22419 14681 14686 17454 16439 REGULATION OF RAS BY GAPS%REACTOME%R-HSA-5658442.1 Regulation of RAS by GAPs 19186 19188 18176 226525 114715 57296 67151 66413 211255 19185 66998 53380 19192 15461 26445 17463 19166 69077 26444 26446 26443 19414 56438 114713 22123 18015 59029 19184 19179 22190 20422 667035 19182 240057 19181 23997 66997 218397 16913 228769 70247 19175 67089 19177 19170 21762 23996 103554 16912 26554 19173 54153 19172 320484 69601 73902 19167 26441 114716 19415 19171 16653 26442 26440 101809 UPTAKE AND FUNCTION OF ANTHRAX TOXINS%REACTOME%R-HSA-5210891.1 Uptake and function of anthrax toxins 18550 26396 26395 640703 26400 26398 18571 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT)%REACTOME%R-HSA-917729.1 Endosomal Sorting Complex Required For Transport (ESCRT) 52348 194309 66700 66914 330192 22088 20479 22190 70160 116733 107305 28084 667035 68953 105513 20844 15239 56324 208092 66371 75608 66201 27681 76959 ADRENALINE SIGNALLING THROUGH ALPHA-2 ADRENERGIC RECEPTOR%REACTOME DATABASE ID RELEASE 57%392023 Adrenaline signalling through Alpha-2 adrenergic receptor 11551 11552 11553 SIGNALING BY GPCR%REACTOME DATABASE ID RELEASE 57%372790 Signaling by GPCR 13363 20423 16147 258659 258640 258292 259147 258163 258443 258656 257898 258381 257917 258371 404346 258222 258296 258616 258704 258151 258405 258563 18313 258470 258672 258153 258690 18314 18312 258821 258373 257884 258358 258937 258702 258763 258179 258703 258271 259049 259066 258025 258857 258439 258836 668035 258075 259089 259012 22416 18369 216795 259095 258657 259092 258542 258769 258729 16952 258347 258935 258321 259071 22417 258487 258486 258939 258609 258268 258908 258749 259097 258318 258985 56858 258420 258776 57251 258515 259035 258531 258352 257972 258507 259063 258814 258946 258305 258759 258407 258804 258287 259074 258975 258275 404331 258506 258775 258338 258544 258387 258772 258354 259051 57271 259002 100043474 258424 259100 258147 17392 258469 258455 258206 100038859 259058 258746 258481 259045 258355 257883 258325 258536 56015 259019 258562 258881 258713 258098 258302 258756 258478 14682 259036 14675 259034 21390 258614 14676 258319 14672 258914 14674 258710 258238 258694 258700 404315 259119 259075 258819 257905 258720 259047 258717 18366 404318 18367 436002 258154 258600 20607 258160 258036 207911 18341 258427 18330 258350 258178 404222 23945 19045 12000 11848 22094 26361 54140 14308 207728 23984 243764 241489 54611 18576 11540 11539 11541 11542 14370 14365 14367 22418 57265 14816 140795 67168 78826 108071 14678 14677 14679 70839 74191 57385 233571 235036 18441 18442 78134 574402 57257 22325 107221 12640 242851 14362 16866 233081 14366 14369 19353 225642 11607 18783 11998 320129 21336 104709 30955 320207 16443 15466 99296 15465 225192 14681 14685 14686 14687 258322 18328 258866 258270 258990 18322 259053 258586 258869 259041 258248 258357 259110 259109 258580 258582 258587 259112 258362 258363 258575 258853 258601 258650 80706 259106 258675 259014 259054 404317 258636 259115 18365 258805 258961 258736 258882 258097 259015 258991 258944 258992 258941 258299 242425 258618 258216 228228 244187 258572 259004 667918 257916 258697 54393 258752 258925 258896 259122 258924 170639 668825 259113 259017 258155 258680 258303 258620 29849 258933 258606 18317 257962 258310 258395 258334 258196 18357 258715 18315 18346 258267 258922 258207 258316 546747 18343 258408 257909 258432 258832 258608 259067 18310 259040 329460 258794 258281 404329 258677 258846 117004 258016 258027 404319 545140 258930 258658 258831 218066 259013 258105 259111 258453 258706 258573 18331 257985 258340 258854 258673 258039 258980 258458 14680 18324 18796 18795 15563 15562 18751 15560 15550 15566 15565 15552 15551 15559 18798 15558 18797 15557 15874 19878 56212 19354 11852 11853 319430 19739 12772 20287 11517 14706 24012 14607 14696 14526 14527 224014 11516 269608 14602 14688 101497 14708 12458 13605 14693 14709 75547 26382 14601 16800 14697 16801 19206 56438 319757 26395 19216 67603 19218 14764 319520 19220 11820 22411 14699 66066 14700 14701 14695 18755 93896 14652 14704 331374 14702 56077 381853 14065 14710 66082 64337 320127 380921 110524 104418 13139 14062 14673 110197 76192 231871 269060 11552 14064 235584 217480 26403 16416 12223 54519 100042150 21894 11600 12273 19060 19186 15139 19188 327826 17169 194231 109905 14161 12266 226525 12267 57296 67151 215449 18710 19185 66998 53380 14172 19395 21338 17967 15461 17463 83409 69077 29875 110651 20210 21333 21334 21337 20111 12912 26417 57349 56744 26413 23939 20112 385643 12323 108058 12322 18015 59029 19197 19417 19184 19179 20422 171463 14573 19182 16590 240057 19181 231474 80903 23997 19056 66997 19055 18039 218397 110135 14585 14178 228769 70247 67089 14586 14587 21762 23996 20416 11876 14165 26554 18596 19204 109880 16399 54153 18761 15200 640703 18673 12325 16706 69601 83379 50779 22371 19058 73902 233046 114716 12981 19415 63953 50782 14174 12982 19252 16653 12984 240672 13537 12988 67836 16186 13385 14588 211323 16184 11836 18188 20740 20739 13645 16185 16452 216869 109689 18176 72399 70686 545156 114715 240168 14268 66413 211255 19219 18183 14083 16451 19192 16453 26445 19166 18218 14812 76089 26444 26446 14811 26443 14813 19414 80297 14814 74769 16183 20742 18707 18709 20741 21687 20743 16367 13866 14810 16192 26396 14360 16191 216148 114713 14186 19418 22123 18167 12767 76854 58175 18168 12854 56838 227288 240816 12765 14739 236915 217212 381810 227326 330122 14823 624910 20662 14170 19262 640524 22065 16913 75590 19175 19177 19713 19170 22330 99571 13874 67839 103554 19065 19064 16912 12774 54401 18619 100038965 83961 16188 20606 100039973 19173 19172 110312 51791 107971 22068 100986 387513 65086 18611 23980 17329 387349 20418 320484 57254 384783 387342 245684 626596 12145 67112 110157 108073 19167 108069 26441 84112 19419 19736 11472 14825 235611 387616 19171 545987 50778 12775 13649 70727 12776 20310 18595 26442 12778 12768 26440 67792 12771 101809 18591 12773 18750 19088 22415 18753 18754 22423 54126 213788 26946 18752 104110 229709 17200 104443 230777 229214 14539 237362 12057 13603 15171 353344 30044 20132 57811 20890 51801 223780 11535 54615 12311 12310 227717 56089 387285 54409 22408 20293 13489 11548 11549 12671 11550 12669 12672 18241 13490 13491 14773 18573 16867 19877 381413 319239 19214 224129 80910 14309 11513 238725 11512 212108 100043254 11515 22353 11514 17202 17199 17201 17203 26385 22095 209512 71223 12326 215855 11652 114640 218461 22354 11651 16336 243270 16440 80885 22410 71704 93690 110355 382348 18747 213498 18574 102098 16438 277360 110385 18749 226970 18577 207212 13492 210044 20663 19228 18575 73341 213527 432530 238871 56349 19773 23797 12922 104111 14608 18583 18584 171207 18578 24001 13488 239530 223435 215854 109904 29863 19087 12918 19085 14761 18607 227289 19084 19226 111174 22324 12921 109934 22355 69632 19217 19227 30938 383563 21844 381489 17207 503558 230972 19222 213649 11554 16439 53972 11556 14163 140498 58182 246313 23832 319197 233079 14368 14763 229791 18217 22045 272031 217369 20312 246691 75769 20299 22044 14744 233080 20302 13051 436440 252837 280287 208188 56696 14063 12424 12209 12425 11555 13618 24111 18101 68039 171469 14715 114229 23925 67405 235044 16963 226278 13615 13614 58861 57260 14714 54199 20303 238377 20295 20306 20296 20292 50501 13616 13617 623503 22439 20290 14829 59289 54598 210198 13733 22414 93735 19207 26364 22421 22422 110326 83770 22412 14371 18429 18430 22409 93897 22413 22420 83771 64214 381073 71729 353165 17773 244701 23919 15199 56066 239336 109648 12374 20315 11609 387512 15945 18386 94226 20609 14427 57253 18389 14429 12568 14428 14293 387347 20608 55985 574417 208990 14289 14294 110168 20297 18166 14419 387355 18155 20304 30878 387356 20604 216749 56470 14745 242093 13610 12801 13609 67865 353148 19737 12802 387353 66102 12769 387515 13611 387348 19734 108068 19057 53978 246709 268934 22190 667035 64654 14173 14164 18216 80857 12426 224065 14180 13349 16995 216152 70086 14175 14177 239283 226304 12766 12062 18387 14389 80901 14767 18708 12777 56183 18706 12061 20605 433292 20311 20300 23796 14061 18610 18390 19052 19053 73699 51792 21770 26932 226849 26931 225849 19156 11606 11551 11553 212541 52666 14459 18976 19735 50780 56533 19049 POU5F1 (OCT4), SOX2, NANOG REPRESS GENES RELATED TO DIFFERENTIATION%REACTOME%R-HSA-2892245.1 POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation 20674 18999 100038891 RECRUITMENT AND ATM-MEDIATED PHOSPHORYLATION OF REPAIR AND SIGNALING PROTEINS AT DNA DOUBLE STRAND BREAKS%REACTOME DATABASE ID RELEASE 57%5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks 17535 12021 319181 19060 70620 15204 70681 240087 12189 11920 93762 382522 70238 210766 27223 22059 11350 20184 59004 319183 14048 14049 22190 193796 319182 319178 230674 319186 667035 14051 14050 319190 11785 107823 26419 93765 22196 19360 107976 319152 68251 104416 81601 22385 27354 50883 319188 15270 78303 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE%REACTOME%R-HSA-76042.1 RNA Polymerase II Transcription Initiation And Promoter Clearance 67710 68776 66464 21374 17749 66420 245841 235459 209361 66467 20021 69241 99730 319944 24074 108143 229906 83602 270627 14884 66671 228980 68153 74197 23894 12572 226182 216185 17420 13871 13872 209357 69833 14885 68705 72504 20022 69920 21343 231329 98053 407786 100043714 20020 DEVELOPMENTAL BIOLOGY%REACTOME DATABASE ID RELEASE 57%1266738 Developmental Biology 12827 12289 12295 12829 57810 12297 12839 20452 12298 12830 12835 12833 11603 12828 12826 59287 140858 13636 13838 13839 13836 69585 13840 114255 13841 76829 13638 623279 230126 20562 76707 68799 210801 244058 20564 13639 22253 13430 13637 216439 13842 18738 13835 22289 13000 103967 100039026 18481 76499 56438 18222 13640 13837 67252 224105 16475 16476 17260 26395 12491 67603 319520 381022 17258 231051 213464 13844 12661 11658 23808 70584 216963 26399 241656 214230 319713 73086 226251 231148 213119 53870 18187 56705 110596 235584 104099 26403 18186 16416 12223 22177 16402 54519 100042150 21894 11600 19060 19186 19188 327826 17169 194231 109905 14161 226525 57296 67151 215449 13193 18710 12805 19185 53378 66998 53321 53380 14172 17967 268902 15461 17463 83409 69077 29875 11488 246316 110651 56839 213469 23792 20111 12912 26417 58184 26413 243914 23939 11496 20112 109700 12323 108058 12322 18015 59029 19197 19417 19184 13001 17390 19179 20422 171463 14573 19182 16590 240057 19181 231474 80903 23997 66997 18039 218397 17395 110135 13429 14585 14178 228769 70247 67089 14586 14587 21762 23996 20416 12385 11876 14165 26554 18596 109880 16399 54153 15200 18761 640703 18673 12325 83433 16706 69601 16886 83379 22371 73902 233046 114716 12981 19415 63953 14174 12982 19252 16653 12984 240672 17904 13537 12988 67836 16186 13385 14588 56406 211323 18550 16184 11836 18188 20740 11772 20739 13645 16185 18553 16452 216869 109689 18176 72399 545156 11771 70686 114715 71770 240168 14268 66413 211255 18183 11770 14083 16451 19192 16453 26445 19166 18218 14812 76089 26444 26446 14811 26443 17979 14813 12757 19414 232910 80297 14814 74769 11773 16183 20742 18707 18709 20741 21687 103968 20743 16367 16956 13866 14810 16192 26396 14360 16191 216148 57875 114713 14186 19418 22123 232906 16571 11848 20662 22063 14170 19262 640524 67300 22065 16913 75590 19175 19177 19713 19170 22330 99571 13874 22066 103554 16912 54401 83961 16188 19173 19172 22068 107971 100986 12331 18611 23980 22067 20418 320484 384783 245684 67112 110157 19167 26441 19419 11472 235611 19171 17295 545987 20354 13649 223881 70727 18595 26442 26440 101809 18591 18750 20674 11487 16334 54126 19247 26946 20404 232440 13848 13591 270190 22408 13845 13654 13641 13846 15481 66556 14106 13643 13642 624153 625328 51788 15077 12608 319149 15412 15400 15401 19877 13018 17268 15394 17344 67278 15399 15436 16772 15434 16658 16777 15429 18771 18803 56458 17928 56484 21413 332221 12555 17927 83557 11652 17877 20526 383491 18717 12558 18088 18209 18514 11651 17259 53626 12609 13449 15377 12606 12386 378435 16600 18007 18506 22410 12561 18012 12175 21405 15183 17878 11352 11819 213498 18747 70834 15376 12224 21423 12840 214968 12296 18749 67784 58226 140571 12291 20663 243743 12288 12834 208117 18845 20450 16398 19122 23797 245026 239556 21367 12841 223435 12292 226519 19165 100039623 100042305 14388 56216 15529 69632 15423 20358 21844 12517 20349 15407 16412 18844 15410 57764 54712 103889 16410 53972 20361 329559 20351 109151 74947 21406 17261 80509 20907 17973 17096 57257 56378 22632 12631 22325 11350 22658 15519 330662 66713 18508 22323 16846 19264 259302 19353 19646 14270 21926 75613 94112 21372 30942 17127 18534 53310 59024 19664 327987 117600 223666 18208 20563 14733 19876 58234 319181 19016 12568 19013 19014 382522 15205 68975 70625 234959 70208 264064 13176 171285 107448 56771 13004 107449 319183 18846 20185 20602 227377 20346 20528 22190 319182 319178 319186 667035 319190 64654 14173 14164 20848 80857 14180 69792 11733 14175 16443 14177 11735 74325 14389 18708 18706 59035 56613 22350 17698 19684 12934 319188 71653 14159 15270 78303 13626 11450 58198 20933 99377 67219 15221 18999 22773 100038891 229003 23989 69790 76199 67071 28077 104625 66999 54376 245688 12300 12569 13819 12914 18609 53417 218772 18096 81905 328572 19213 19401 15379 110351 19411 11925 54377 19052 19053 73699 20130 13383 12567 21803 246086 51792 21410 12445 381379 26416 66993 56637 17128 21770 17126 26932 226849 12387 26931 225849 216154 19697 18033 20788 18128 319169 108098 14056 67710 20437 17749 66420 245841 20021 69241 20356 19017 29857 103988 19094 16542 67279 15874 18119 319176 620395 269275 13590 72821 11481 16728 110862 319504 16536 20266 235281 24046 20265 71960 20269 110880 17978 67938 69833 20022 69920 14783 231329 67268 20181 12622 100043714 320202 20020 11479 11480 17977 52615 15267 12933 22240 56443 26757 18643 65254 18645 11461 16885 66172 14786 55982 81004 19878 20264 269116 399548 15516 20271 17886 20272 56212 20273 13448 20274 110876 22612 19354 18479 319168 26896 11852 76709 319167 51813 17909 11465 67224 73178 11853 68089 20439 74117 78334 14026 67771 11867 17880 17974 67381 77579 26423 192191 HS-GAG DEGRADATION%REACTOME DATABASE ID RELEASE 57%2024096 HS-GAG degradation 15530 14734 14735 20971 103978 20969 27029 11603 110006 20970 15931 15442 15529 27419 14733 71951 15932 12091 545291 23888 METABOLISM OF STEROID HORMONES%REACTOME%R-HSA-196071.2 Metabolism of steroid hormones 114664 15483 56348 15486 78925 15485 94224 15484 14187 14149 13070 170460 66065 13075 18976 100042622 20845 68165 170459 11677 14148 110115 13074 15487 15492 15497 12640 13072 16866 13079 57357 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS%REACTOME%R-HSA-196849.1 Metabolism of water-soluble vitamins and cofactors 100705 665563 216188 110948 109754 72621 110821 109672 72039 54338 66904 68421 330064 109136 26363 105663 100039707 78038 54219 109129 238505 67096 210009 59027 93835 246703 14603 67375 65969 14104 116914 78914 29807 66454 19225 67993 226518 192185 223646 74080 269614 106564 17250 19223 68591 74450 268566 73132 69372 71743 75735 17434 211347 66812 22072 270685 20509 20522 52466 108037 77697 107476 17769 66473 67618 108156 107747 13124 76701 19300 17768 69906 11433 20425 21452 18563 17850 68214 11761 20525 216134 14873 13361 103711 20527 54391 18605 69698 319945 PEROXISOMAL LIPID METABOLISM%REACTOME DATABASE ID RELEASE 57%390918 Peroxisomal lipid metabolism 110959 74147 74114 11666 12908 80911 74121 15926 56690 67528 20524 113868 111175 228061 56794 74159 16922 17117 56185 170789 26458 14712 15488 67131 93732 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER%REACTOME DATABASE ID RELEASE 57%76071 RNA Polymerase III Transcription Initiation From Type 3 Promoter 17749 21374 66420 245841 20841 20016 26939 70408 67486 12909 78929 20018 67065 67005 218832 69870 70428 74414 544971 227644 75627 102209 77634 330959 69833 66653 100043714 18986 SYNTHESIS OF LIPOXINS (LX)%REACTOME%R-HSA-2142700.2 Synthesis of Lipoxins (LX) 11690 17001 11689 11684 67103 15446 GLUCONEOGENESIS%REACTOME DATABASE ID RELEASE 57%70263 Gluconeogenesis 78830 13358 230163 14447 27376 14751 11674 50799 18663 14719 74551 14718 17449 18563 13806 18747 18639 100043349 18749 67863 13807 13808 18534 14120 21991 18655 14121 17448 11676 18648 56012 STABILIZATION OF P53%REACTOME DATABASE ID RELEASE 57%69541 Stabilization of p53 19186 19188 57296 67151 66413 17248 26374 19185 11920 66998 53380 19192 17463 26445 19166 69077 26444 26446 22059 26443 22123 59029 19184 22190 19179 20422 667035 19182 19181 23997 66997 16913 228769 70247 19175 67089 19177 19170 21762 23996 103554 16912 19173 19172 17246 73902 19167 50883 26441 19171 26442 26440 TRAF3 DEFICIENCY - HSE%REACTOME%R-HSA-5602571.1 TRAF3 deficiency - HSE 106759 142980 22031 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE%REACTOME DATABASE ID RELEASE 57%606279 Deposition of new CENPA-containing nucleosomes at the centromere 320394 15267 12615 319183 19646 72155 319181 60411 56505 319182 319178 319186 319190 69928 232440 52504 217653 70645 66578 319168 71876 93762 382522 319167 70454 319176 67733 83815 102920 66311 76464 20892 100038822 66570 233532 18148 624153 51788 66336 12617 319188 15270 319169 78303 245688 26886 TRNA MODIFICATION IN THE NUCLEUS AND CYTOSOL%REACTOME%R-HSA-6782315.3 tRNA modification in the nucleus and cytosol 209584 78697 69786 17299 66369 68205 30947 229780 73681 68260 108943 328162 66628 67667 76367 68916 319582 329504 60507 67674 66966 66757 76357 28114 66246 57773 13434 233189 68736 78890 100043886 107508 66965 212528 106248 100929 C-SRC MEDIATED REGULATION OF CX43 FUNCTION AND CLOSURE OF GAP JUNCTIONS%REACTOME DATABASE ID RELEASE 57%191647 c-src mediated regulation of Cx43 function and closure of gap junctions 14609 21872 AUTOINTEGRATION RESULTS IN VIRAL DNA CIRCLES%REACTOME%R-HSA-177539.1 Autointegration results in viral DNA circles 15361 101739 23825 HYDROLYSIS OF LPE%REACTOME%R-HSA-1483152.3 Hydrolysis of LPE 232889 74182 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY%REACTOME%R-HSA-3371599.1 Defective HLCS causes multiple carboxylase deficiency 100705 110821 72039 66904 78038 107476 18563 ASSEMBLY OF THE PRIMARY CILIUM%REACTOME%R-HSA-5617833.2 Assembly of the primary cilium 19889 74025 12879 56350 106840 76816 18817 56455 76478 71909 219072 214552 237222 20873 18536 104318 22145 73738 26370 74470 219103 17997 99100 12469 74360 211446 68121 20336 18472 27373 12009 13589 53413 54130 76707 12465 230376 21454 66296 12462 236266 12461 78887 12464 18005 15519 102058 381644 22154 225745 214444 107338 28135 231123 13427 319757 13424 83922 208518 75786 18541 110350 103733 101565 78177 17274 69654 22153 225659 227613 16328 53598 22142 68475 213575 109181 105504 22627 51792 11843 16568 64436 16570 100986 74201 73916 67161 213081 19088 320299 81896 21821 66061 106633 75465 73668 67068 67661 73242 13196 76779 76411 232944 245866 100041639 217335 78802 380718 654470 72421 16569 140810 18764 12589 72938 329795 260305 77048 18763 74019 68259 67694 264134 68146 67286 68097 382090 71820 27078 277939 217935 215445 15185 22628 76568 53885 16559 12534 244585 74682 72140 67590 212541 67344 53869 16579 107371 232987 238799 18747 75296 233649 69940 71492 67042 52028 231214 72569 52906 76260 93730 18000 216363 109242 67978 66482 20607 71769 207911 319845 67378 56297 102774 18582 59030 12789 241950 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND%REACTOME%R-HSA-69183.1 Processive synthesis on the lagging strand 327762 67967 16881 18969 14156 19075 18972 18538 19891 69745 68240 18971 68275 18968 19076 APOBEC3G MEDIATED RESISTANCE TO HIV-1 INFECTION%REACTOME%R-HSA-180689.1 APOBEC3G mediated resistance to HIV-1 infection 268373 15361 101739 23825 GENERATION OF SECOND MESSENGER MOLECULES%REACTOME%R-HSA-202433.2 Generation of second messenger molecules 17973 630146 22376 12504 16822 17444 14026 16818 16428 18803 18481 12500 12502 12501 14960 22323 14968 18479 22637 23880 14969 16797 224105 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS%REACTOME DATABASE ID RELEASE 57%2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 18519 11487 56233 11491 333639 59287 54485 13388 16450 16449 433586 103806 79221 170787 225164 208727 15208 240055 433759 15205 26965 15213 15182 76580 15185 232232 70315 56198 15214 264064 15184 56438 12914 20185 328572 20602 22190 18011 667035 81004 14534 21402 21372 17869 15183 51813 270118 208117 19165 19664 100039623 100042305 18128 PI3K CASCADE%REACTOME%R-HSA-109704.1 PI3K Cascade 19247 75778 327826 108099 19079 108097 19082 14172 83409 667739 74769 74370 18709 16367 208643 14186 81897 56717 22084 75669 225326 64654 14170 80903 14173 14164 11652 13684 11651 14178 80857 14180 228775 18576 14175 14177 75705 19042 108079 64930 241113 12283 14165 72149 54401 13631 66096 18708 18706 67605 56716 384783 83379 67112 18607 14388 13685 54170 245670 14174 545987 68576 20869 68441 66508 227154 52187 69008 105787 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM%REACTOME%R-HSA-535734.4 Fatty acid, triacylglycerol, and ketone body metabolism 110821 66904 109151 14245 80509 99010 13358 15107 93747 11364 11655 75613 12491 94112 21372 14219 59024 327987 67512 55979 99035 56348 14732 19063 18045 217166 12686 66775 104112 106529 231510 433256 54397 170439 329910 14081 14555 94180 30963 26457 333433 78245 19016 14104 210992 13167 19013 20249 74559 19015 215456 66113 28169 19014 243078 74205 56360 74156 50790 14626 68801 54326 66834 171210 171281 69923 264895 68975 70625 234959 83603 67800 14933 216739 70208 15487 264064 257633 171282 13350 225010 57874 102247 171285 66198 72482 233549 231086 56771 18046 107476 68262 70025 68393 97212 70757 328845 52123 18044 54325 20185 20602 64898 245532 69792 20466 59035 64899 97064 100705 12895 12896 57279 56406 109136 12894 67460 20933 14080 67219 21677 11806 15360 100040592 229003 110446 11303 11409 17764 11807 23989 69790 170826 17979 18181 11363 76199 78894 71985 28077 76267 66999 19731 57875 73724 394434 12914 328572 14137 18631 20683 108079 381379 66993 12753 73690 22601 17436 15356 216154 195733 20788 20859 14200 13177 66905 108098 94185 18670 75778 69772 26379 19017 108099 14571 108097 11520 234309 67279 11370 11606 100040843 13122 19883 17978 20186 170789 20181 17977 11865 66172 107765 81004 21678 208982 21679 67041 21676 18143 26896 228775 26378 15183 13076 51813 14979 17850 67224 78334 24001 14373 50493 75772 67381 102632 192191 71911 NEGATIVE REGULATION OF FGFR4 SIGNALING%REACTOME%R-HSA-5654733.1 Negative regulation of FGFR4 signaling 19247 22190 17346 667035 327826 12402 24064 64654 19052 80903 14173 19053 14170 14164 14172 80857 14180 51792 14175 14177 109880 26417 26413 83379 14186 TP53 REGULATES TRANSCRIPTION OF DNA REPAIR GENES%REACTOME%R-HSA-6796648.2 TP53 Regulates Transcription of DNA Repair Genes 67710 17749 66420 208836 245841 66467 20021 20833 69241 240087 12189 11920 20924 20922 69562 14884 22059 12572 17420 107986 69833 68705 20022 69920 231329 14088 98053 211651 69131 100043714 20020 107951 11909 16476 12454 114741 24116 66671 18861 19364 17350 23894 17685 57314 27632 13871 13872 58202 209357 14885 13716 67655 14281 67923 27224 12649 72949 12455 21399 CONSTITUTIVE SIGNALING BY EGFRVIII%REACTOME%R-HSA-5637810.1 Constitutive Signaling by EGFRvIII 20416 18708 18706 13645 12402 15519 18176 18803 12539 20662 14388 13649 16653 15461 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC%REACTOME DATABASE ID RELEASE 57%983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC 21356 20334 14991 14827 21355 14828 218811 69162 240095 15006 21354 15007 69608 80898 12330 77371 667803 66397 99683 12010 12317 110379 SIGNALING BY HIPPO%REACTOME DATABASE ID RELEASE 57%2028269 Signaling by Hippo 56332 50523 13543 12367 54401 68473 21873 211652 64010 22601 75723 232157 260305 56274 97064 22627 21872 16798 58231 REVERSAL OF ALKYLATION DAMAGE BY DNA DIOXYGENASES%REACTOME DATABASE ID RELEASE 57%73943 Reversal of alkylation damage by DNA dioxygenases 26383 69113 268420 69090 77987 75452 231642 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME DATABASE ID RELEASE 57%2979096 NOTCH2 Activation and Transmission of Signal to the Nucleus 225164 11487 240055 208117 22190 76580 18011 667035 19165 59287 54485 100039623 17242 13388 16450 100042305 12805 16449 18129 DISINHIBITION OF SNARE FORMATION%REACTOME%R-HSA-114516.2 Disinhibition of SNARE formation 18750 20912 18751 20909 18752 INTRINSIC PATHWAY OF FIBRIN CLOT FORMATION%REACTOME DATABASE ID RELEASE 57%140837 Intrinsic Pathway of Fibrin Clot Formation 16621 12261 268591 54368 14723 19123 14729 14724 232345 22371 15160 58992 20720 14058 14071 11905 14069 109821 12258 385643 14061 72461 DEFECTIVE ACTH CAUSES OBESITY AND PRO-OPIOMELANOCORTININ DEFICIENCY (POMCD)%REACTOME%R-HSA-5579031.1 Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) 17200 18976 FATTY ACYL-COA BIOSYNTHESIS%REACTOME%R-HSA-75105.4 Fatty Acyl-CoA Biosynthesis 13358 99035 56348 19063 12686 66775 104112 75778 106529 433256 54397 170439 329910 14081 94180 30963 78245 14104 13167 20249 74559 243078 74205 56360 74156 50790 68801 54326 66834 171210 171281 69923 264895 83603 216739 15487 257633 171282 57874 170789 66198 72482 107476 70025 70757 328845 54325 ABC-FAMILY PROTEINS MEDIATED TRANSPORT%REACTOME DATABASE ID RELEASE 57%382556 ABC-family proteins mediated transport 66753 11806 66413 76408 19192 26445 19166 77706 26444 27404 26446 17250 26443 12780 27421 239273 24014 74610 24015 74104 56199 56325 18671 22123 11304 224742 26905 67470 224814 27416 27409 67204 16913 19175 19177 11307 19170 103554 16912 19173 19172 19167 26441 19171 70377 26442 20927 26440 226144 67819 26874 27403 217265 19299 11305 217262 19298 18670 74591 19186 19188 269523 57296 67151 20928 19185 66998 53380 20338 17463 12638 69077 13665 193670 54197 116891 216440 16514 27410 56535 76184 192663 59029 11666 19184 22190 19179 20422 667035 19182 19181 23997 66997 228769 70247 67089 21762 23996 244373 73902 MITOCHONDRIAL TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 57%5368286 Mitochondrial translation initiation 56284 56282 24030 14548 67707 94061 69956 94067 107734 68611 67681 74600 78523 66419 60441 56280 121022 69527 66407 77721 66230 68537 67994 28028 64655 66242 68565 69163 76366 67840 68735 27398 65111 216767 67308 66047 52443 66163 64657 69606 99045 118451 64656 79044 76784 59054 27397 66493 67036 218506 94063 353242 64660 68499 66973 75398 107732 66223 27393 68836 67212 18120 66121 50529 66258 57312 623346 232536 102060 94062 64659 107733 68463 622268 66845 66077 94065 66292 100042811 66448 18100 94066 64658 68572 100040519 MELANIN BIOSYNTHESIS%REACTOME%R-HSA-5662702.1 Melanin biosynthesis 22173 13190 CONJUGATION OF PHENYLACETATE WITH GLUTAMINE%REACTOME DATABASE ID RELEASE 57%177162 Conjugation of phenylacetate with glutamine 117147 MAPK1 (ERK2) ACTIVATION%REACTOME%R-HSA-112411.1 MAPK1 (ERK2) activation 16194 16193 19247 26396 54721 16451 16452 26413 SPRY REGULATION OF FGF SIGNALING%REACTOME DATABASE ID RELEASE 57%1295596 Spry regulation of FGF signaling 19052 19053 109880 19247 22190 17346 26417 667035 51792 12402 26413 24064 PURINE CATABOLISM%REACTOME%R-HSA-74259.1 Purine catabolism 23959 76952 14544 50773 230718 14775 22436 12359 18950 HYALURONAN BIOSYNTHESIS AND EXPORT%REACTOME DATABASE ID RELEASE 57%2142850 Hyaluronan biosynthesis and export 15118 27416 80982 15117 15116 PHOSPHORYLATION OF THE APC C%REACTOME%R-HSA-176412.1 Phosphorylation of the APC C 66156 52206 668450 18817 22194 52563 59008 99152 56317 75430 216080 12534 69957 217232 52717 68999 68612 17222 PLC-GAMMA1 SIGNALLING%REACTOME DATABASE ID RELEASE 57%167021 PLC-gamma1 signalling 18750 19088 18573 18753 224129 18754 11513 11512 11515 11514 18752 104110 229709 18803 18049 18211 12326 16440 110355 18747 18574 16438 18749 210044 18575 432530 104111 12912 640703 19087 19085 19084 16439 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 57%68867 Assembly of the pre-replicative complex 19186 19188 57296 67151 66413 19185 66998 53380 18392 19192 26428 18393 26445 17463 26429 19166 69077 26444 26446 26443 13557 13555 242705 22123 59029 19184 19179 22190 20422 57441 667035 19182 19181 23997 66997 16913 228769 50793 19175 70247 19177 67089 19170 21762 23996 17215 17219 103554 17217 16912 56452 19173 66634 19172 67177 73902 19167 26441 23834 19171 17216 26442 26440 17220 17218 CELL-EXTRACELLULAR MATRIX INTERACTIONS%REACTOME%R-HSA-446353.1 Cell-extracellular matrix interactions 192176 109711 73341 19303 21754 57342 225341 68794 74202 20163 16202 22323 170736 16412 218952 REGULATION OF THYROID HORMONE ACTIVITY%REACTOME%R-HSA-350864.1 Regulation of thyroid hormone activity 13370 13371 107585 METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS%REACTOME%R-HSA-2022377.3 Metabolism of Angiotensinogen to Angiotensins 13809 11421 56373 12873 76703 17228 70008 13035 14943 64138 17380 70495 100038824 13033 72061 11606 16790 DNA DAMAGE REVERSAL%REACTOME%R-HSA-73942.1 DNA Damage Reversal 26383 69113 268420 69090 77987 75452 17314 231642 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION%REACTOME%R-HSA-2029482.1 Regulation of actin dynamics for phagocytic cup formation 20963 14083 17973 246256 57257 20430 56378 330319 17913 83767 242687 26417 12631 22325 26413 11350 15519 330662 66713 105855 14131 245880 140580 50884 108100 19353 56443 68524 11461 16885 329165 101314 140579 14129 15516 17886 12229 17882 12502 76884 12928 18479 80987 17918 76709 17925 17909 215280 11465 73178 22376 68089 74117 11308 67771 11867 22324 BETA OXIDATION OF HEXANOYL-COA TO BUTANOYL-COA%REACTOME%R-HSA-77350.1 Beta oxidation of hexanoyl-CoA to butanoyl-CoA 15107 93747 231086 97212 11409 DISEASES OF IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 57%5260271 Diseases of Immune System 266632 106759 12475 142980 117149 22031 17874 12675 12491 19697 21899 18033 18036 18035 17087 16151 12229 18034 16150 24088 53791 21897 21898 PHOSPHOLIPASE C-MEDIATED CASCADE; FGFR3%REACTOME DATABASE ID RELEASE 57%5654227 Phospholipase C-mediated cascade; FGFR3 18750 18573 19088 18753 224129 18754 11513 11512 11515 11514 18752 104110 229709 18803 64654 14173 80903 14164 12326 80857 14172 16440 14180 110355 18747 14175 18574 16438 18749 210044 18575 432530 104111 12912 640703 19087 19085 19084 16439 AMINE OXIDASE REACTIONS%REACTOME%R-HSA-140179.1 Amine Oxidase reactions 109731 212503 17161 REGULATED NECROSIS%REACTOME DATABASE ID RELEASE 57%5218859 Regulated Necrosis 22030 56532 14082 21933 14102 14103 11797 22035 12370 71609 19766 74568 11796 11798 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL%REACTOME%R-HSA-202733.2 Cell surface interactions at the vascular wall 16416 16402 20344 19247 11600 18176 14268 14061 15461 238055 16331 15170 17096 50934 30962 16728 19124 330836 74769 56744 20540 18709 12505 21687 14360 268373 14456 20737 20343 20339 243816 12523 11931 19261 66053 12481 16408 67374 83995 53896 14786 16149 18106 19128 11602 19123 17289 18803 20662 12389 68891 12506 108078 21824 22612 13449 26570 16423 13052 16400 16401 50915 11601 20345 20416 16409 14127 16403 80879 18708 17136 16414 18706 57274 20501 16818 17254 12215 11932 69524 58217 16411 83964 17319 18613 20340 16653 16456 16412 16410 270152 11933 20539 PD-1 SIGNALING%REACTOME DATABASE ID RELEASE 57%389948 PD-1 signaling 58205 18566 15170 12504 19247 16818 12500 12502 12501 14960 14968 14969 60533 12988 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION%REACTOME DATABASE ID RELEASE 57%504046 RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription 18519 12417 107932 20841 66467 216848 106298 20823 14884 23942 544971 75627 77634 15182 12572 17420 330959 245688 116870 19646 21374 20016 26939 70408 18029 67486 18032 12909 78929 20018 67065 67005 18027 218832 66671 69870 70428 74414 23894 13871 13872 116871 209357 14885 67371 319169 17749 66420 15278 245841 319181 234366 232440 216151 382522 319176 233863 227644 319955 66596 102209 433759 26417 71752 72308 624153 69833 625328 66653 70239 51788 269252 15077 17191 319149 100043714 98488 229542 66136 19285 21341 21340 15267 319183 20017 110147 70333 667501 22130 319182 319178 319186 319190 21429 75316 64424 14534 20019 21339 319168 319167 208595 17192 21780 319188 15270 78303 18986 FORMATION OF TC-NER PRE-INCISION COMPLEX%REACTOME%R-HSA-6781823.1 Formation of TC-NER Pre-Incision Complex 72584 67710 17749 66420 245841 99375 108679 13194 66467 20021 69241 26891 14884 56031 100043806 319955 12572 17420 12848 69833 20022 69920 56438 231329 100043714 20020 26895 328572 22190 667035 66983 71101 71991 26754 26893 67439 66671 57905 26894 23894 22590 13871 13872 209357 14885 11834 26572 252870 21399 28000 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION%REACTOME%R-HSA-162658.1 Golgi Cisternae Pericentriolar Stack Reorganization 12534 99412 76308 19324 66352 12442 18817 70231 26413 56041 74498 59021 FCERI MEDIATED CA+2 MOBILIZATION%REACTOME DATABASE ID RELEASE 57%2871809 FCERI mediated Ca+2 mobilization 16822 20963 229709 16428 22165 18803 234779 20662 19056 12229 19055 16440 16438 18018 18019 17096 57257 17444 640703 22325 18021 19058 22324 16439 21682 UPTAKE AND ACTIONS OF BACTERIAL TOXINS%REACTOME%R-HSA-5339562.1 Uptake and actions of bacterial toxins 20980 64176 22318 18550 13629 15200 12527 640703 26395 26400 64051 26398 18571 15519 75209 15516 50493 56216 22317 20907 20614 26396 20979 CHOLINE CATABOLISM%REACTOME DATABASE ID RELEASE 57%6798163 Choline catabolism 100434 110695 192166 74129 12116 218865 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE%REACTOME%R-HSA-3371453.1 Regulation of HSF1-mediated heat shock response 218210 66679 18226 14828 69912 227720 54563 223921 19891 103468 70699 68240 72787 11920 269113 231042 234865 69736 19069 107939 12017 110920 170762 17164 193740 15481 81489 26417 93759 15482 15512 26413 59015 67669 15499 227699 56354 22791 18141 15505 66538 18415 70369 445007 50497 15526 213539 68275 73442 108989 219158 19386 72630 29810 15525 69482 70356 71805 23950 22627 67384 56637 NEF AND SIGNAL TRANSDUCTION%REACTOME%R-HSA-164944.1 Nef and signal transduction 15162 140580 19353 14360 94176 16818 224105 INFLUENZA LIFE CYCLE%REACTOME DATABASE ID RELEASE 57%168255 Influenza Life Cycle 16646 76808 68028 100043755 19899 67186 20115 57294 667739 67025 12757 27370 65019 67248 666669 100038991 100038875 15519 100040021 432502 66481 100040298 238217 56040 667618 19989 67300 103573 19384 218210 66679 18226 67710 69912 17749 66420 245841 227720 54563 223921 103468 70699 16211 20021 69241 72787 269113 231042 234865 69736 19069 107939 170762 193740 59015 227699 69833 18141 100037258 68705 20022 69920 445007 231329 98053 12317 108989 19386 100043714 20020 69482 71805 67891 100042986 100042740 621100 100043295 67097 100043000 625646 67281 633683 666899 667035 16785 100039316 267019 100040970 12330 19941 382492 20055 19951 100042670 68193 665189 668182 19921 20044 668144 100043423 100043893 670832 100043876 629957 225058 22121 75617 667279 76846 27050 100043184 19934 231413 100040331 100043391 319195 68172 241053 100043209 20102 67941 27207 70572 668668 20103 672214 622534 20085 20084 ADAPTIVE IMMUNE SYSTEM%REACTOME%R-HSA-1280218.3 Adaptive Immune System 108723 16822 22210 53323 16428 30839 56455 213980 12010 30838 12042 30050 216150 16643 17444 242960 54130 50754 50789 13038 19141 13430 22192 103967 18481 13427 13040 13424 56438 106052 50762 224105 69654 70093 67615 235320 100041484 224826 66743 67921 19820 15001 13057 53598 215061 67455 140499 208154 232539 192656 94090 17874 57751 12491 78913 13058 14998 223864 66772 17970 65257 17972 12229 230903 17969 17237 17533 672511 246278 30945 17534 229445 70928 101358 93765 67345 12703 15000 56508 15002 103583 217217 21898 13034 104184 67731 77113 68431 231863 70294 76375 59009 14794 18744 16924 212919 242785 21899 17087 66589 24088 26410 21897 320118 70392 78541 12223 22177 211007 142688 14828 69299 72194 100042150 12504 76454 67845 242521 67128 19186 269514 19188 22222 327826 627648 207215 100041766 66799 109905 27007 22019 231670 12266 19349 57296 22193 66105 67151 328234 215449 56736 18710 12449 74153 19185 100763 66998 50788 53380 399566 19395 14172 76294 208372 15461 117589 17463 60533 68854 69077 72323 211949 74132 59044 12475 94091 14827 235439 117149 268470 12234 140630 217342 23900 209239 17086 230654 12912 19823 224170 26417 218215 54484 26413 233040 214931 79263 209200 69010 78889 50723 71393 56515 244421 67138 233902 12317 74492 69706 226977 227738 56228 448987 16421 22200 18566 20343 70348 17470 218793 14130 56464 232790 56791 83962 59029 75345 217194 629970 329152 16408 224619 19184 15894 13039 207304 19179 78369 20821 224023 20422 52855 280408 246746 209462 328833 15006 69754 19182 100038830 321006 16590 225825 50760 12520 100039535 19181 84544 224938 140497 217304 228003 80903 83382 109161 23997 12525 68497 66997 57781 22201 50928 13030 81018 12501 667803 22195 232801 13429 22209 12480 69116 14178 240354 20612 330369 228769 13052 65255 70247 16401 65247 67089 52685 380928 12483 22036 26904 74646 21762 22329 226098 23996 140629 75234 231672 14165 217306 243574 26554 19155 18596 433766 76608 117146 16414 213311 15200 18761 30843 640703 78910 142687 83433 64291 16818 28105 15896 67490 65256 83379 16641 226541 243958 231380 73902 54215 230904 224840 80898 58217 19294 68628 635668 30925 68729 54698 269529 100043861 71999 14174 243864 22213 69807 15898 71538 71326 65972 22214 16653 217303 22215 240396 98766 20400 23807 12988 270152 207952 58194 209737 211323 20963 83814 11772 13645 18176 11771 71770 240168 66413 211255 18183 19192 24105 26445 19166 16331 15170 26444 26446 26443 218203 12757 232910 74769 11773 18707 18709 20743 16367 13033 13866 14360 19348 14186 22123 16571 66515 20662 22063 14170 67300 66397 16913 19175 19177 19170 16568 13874 103554 22346 16570 16912 71745 16572 54401 83961 73804 19173 19172 74764 384783 67112 110033 110157 19167 26441 19419 19171 13649 67923 229841 18595 16593 26442 26440 16551 18591 75717 16334 76850 236511 19247 16337 75778 15370 20404 94212 229709 12519 12524 68098 13191 57743 17999 66212 69162 606496 18037 53421 100043039 107568 19696 244650 12015 56424 56717 22084 77647 239528 16149 12371 98432 117150 18803 56458 56484 213988 11652 18717 16396 12478 11651 15937 16440 78757 228775 12487 18747 12550 16438 18749 217351 233833 23797 67605 18720 17246 56716 18719 214150 108083 18607 16419 14388 22324 19211 74244 227743 12526 18718 16412 109270 17454 16410 16439 20811 58988 630146 66313 75788 668303 252903 12402 11840 74947 77371 59288 21356 17973 14991 246256 20619 17096 21355 22320 20909 240095 21354 15007 22319 14960 22323 14968 22637 19260 23880 14969 19264 16797 19271 19353 56371 213575 234663 230979 22428 12477 66156 240028 16563 52206 16573 668450 22194 19025 70620 216080 15204 16569 12500 67588 71819 232943 108012 11768 22631 76580 52563 99152 11767 26934 69957 99683 68999 68612 11765 11764 17222 16579 22190 26409 93836 667035 13032 64654 14173 14164 68652 22034 80857 14180 73470 14175 14177 17060 83490 15985 208650 18708 12518 26377 18706 11769 12143 59008 228421 56317 19822 107995 217232 13426 16594 12702 84585 20333 12576 80751 26965 12575 27401 50868 110350 58205 66663 170737 71865 14897 268291 59026 636931 380711 110351 73998 20469 19052 19053 73699 69608 21402 51792 56637 21770 26932 226849 26931 225849 12675 19697 18033 18036 18035 16151 16150 21947 20334 53859 20437 218811 20866 18751 109305 68097 269717 50873 13036 110379 14129 234779 12330 12502 22612 18479 22376 20439 67665 14026 EXTENSION OF TELOMERES%REACTOME%R-HSA-180786.1 Extension of Telomeres 18973 19687 69263 67967 19718 18969 19075 18972 56505 18538 19891 52530 69745 68240 245474 216853 18971 20174 21752 327762 16881 14156 59001 72151 106344 66979 18974 68275 18968 19076