PROTEIN CITRULLINATION%HUMANCYC%PWY-4921 protein citrullination PADI6 PADI3 PADI2 PADI4 PADI1 METHYLGLYOXAL DEGRADATION III%HUMANCYC%PWY-5453 methylglyoxal degradation III AKR1B10 AKR1B1 CYP2E1 STEARATE BIOSYNTHESIS I (ANIMALS)%HUMANCYC%PWY-5972 stearate biosynthesis I (animals) ELOVL1 ACOT7 ACSL1 ACSL5 ACSL4 ELOVL6 ACSL3 ACOT2 ACOT1 ACSBG1 ACSBG2 SLC27A2 ACOT4 L-SERINE DEGRADATION%HUMANCYC%SERDEG-PWY L-serine degradation SDS SDSL CERAMIDE BIOSYNTHESIS%HUMANCYC%PWY3DJ-12 ceramide biosynthesis SPTLC2 SPTLC3 DEGS2 KDSR SPTLC1 TRYPTOPHAN DEGRADATION X (MAMMALIAN, VIA TRYPTAMINE)%HUMANCYC%PWY-6307 tryptophan degradation X (mammalian, via tryptamine) ALDH3A2 DDC MAOB MAOA AKR1A1 SUPERPATHWAY OF INOSITOL PHOSPHATE COMPOUNDS%HUMANCYC%PWY-6371 superpathway of inositol phosphate compounds PI4K2B MTMR14 PTEN INPPL1 PIK3CD PIK3C2G PIK3CB PIK3C2A PIK3CG PIK3C2B PLCZ1 PPIP5K1 PPIP5K2 PIP5KL1 PLCE1 PIP4K2A PIP4K2B PIP4K2C SACM1L ITPK1 IPMK OCRL ITPKB MINPP1 ITPKC PLCB3 PLCB4 PIK3CA ITPKA PIK3C3 PLCB1 PLCB2 PI4K2A TMEM55A IPPK TMEM55B MTMR3 PIK3R4 PIK3R3 PIK3R2 PIK3R1 PIK3R6 PIK3R5 INPP5B INPP5A INPP5D INPP5J PLCG2 PIP5K1A INPP5K PIP5K1B PLCG1 PIP5K1C IP6K1 CDIPT IP6K3 IP6K2 SYNJ2 FIG4 PIKFYVE SYNJ1 PLCH1 PLCH2 PI4KB PLCD3 PLCD4 PLCD1 PUTRESCINE DEGRADATION III%HUMANCYC%PWY-0 putrescine degradation III ALDH3B1 SAT2 SAT1 ALDH3A2 MAOB ALDH3A1 MAOA ALDH3B2 ALDH2 ALDH1B1 TETRAHYDROFOLATE SALVAGE FROM 5,10-METHENYLTETRAHYDROFOLATE%HUMANCYC%PWY-6613 tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate MTHFD1 MTHFD2 MTHFD2L GART ANDROGEN BIOSYNTHESIS%HUMANCYC%PWY66-378 androgen biosynthesis SRD5A2 HSD3B2 SRD5A1 HSD3B1 HSD17B3 AKR1C3 CYP17A1 PHENYLALANINE DEGRADATION I (AEROBIC)%HUMANCYC%PHENYLALANINE-DEG1-PWY phenylalanine degradation I (aerobic) PCBD2 QDPR PAH PCBD1 TRYPTOPHAN DEGRADATION III (EUKARYOTIC)%HUMANCYC%TRYPTOPHAN-DEGRADATION-1 tryptophan degradation III (eukaryotic) KYNU AFMID ACAA1 KMO ACAT2 ACAT1 ACMSD HADHB GCDH TDO2 HAAO SULFITE OXIDATION IV%HUMANCYC%PWY-5326 sulfite oxidation IV SUOX MEVALONATE PATHWAY I%HUMANCYC%PWY-922 mevalonate pathway I IDI1 MVK ACAA1 HMGCS1 IDI2 ACAT2 PMVK ACAT1 MVD HMGCR HMGCS2 HADHB XANTHINE AND XANTHOSINE SALVAGE%HUMANCYC%SALVPURINE2-PWY xanthine and xanthosine salvage PNP SERINE BIOSYNTHESIS%HUMANCYC%SERSYN-PWY serine biosynthesis PSPH PSAT1 PHGDH MYO< I>-INOSITOL BIOSYNTHESIS%HUMANCYC%PWY-2301 myo< i>-inositol biosynthesis ISYNA1 IMPA1 IMPA2 IMPAD1 ADENINE AND ADENOSINE SALVAGE I%HUMANCYC%P121-PWY adenine and adenosine salvage I APRT D-MYO< I>-INOSITOL-5-PHOSPHATE METABOLISM%HUMANCYC%PWY-6367 D-myo< i>-inositol-5-phosphate metabolism PLCE1 PLCG2 PIP4K2A PIP4K2C PLCG1 PLCB3 PLCB4 PLCH1 PLCH2 PLCB1 PLCB2 PLCD3 TMEM55A MTMR14 PLCD4 PLCD1 TMEM55B MTMR3 PLCZ1 PURINE NUCLEOTIDES DEGRADATION II (AEROBIC)%HUMANCYC%PWY-6353 purine nucleotides degradation II (aerobic) NT5C3A NT5C3B NT5E GDA PNP IMPDH1 IMPDH2 NT5C1A NT5C2 XDH ADA HISTAMINE BIOSYNTHESIS%HUMANCYC%PWY-6173 histamine biosynthesis HDC ASPARTATE BIOSYNTHESIS%HUMANCYC%ASPARTATESYN-PWY aspartate biosynthesis GOT1L1 GOT1 GOT2 UDP-D-XYLOSE AND UDP-D-GLUCURONATE BIOSYNTHESIS%HUMANCYC%PWY-4821 UDP-D-xylose and UDP-D-glucuronate biosynthesis UGDH UXS1 GDP-L-FUCOSE BIOSYNTHESIS II (FROM L-FUCOSE)%HUMANCYC%PWY-6 GDP-L-fucose biosynthesis II (from L-fucose) FPGT FUK PHOSPHATIDYLGLYCEROL BIOSYNTHESIS II (NON-PLASTIDIC)%HUMANCYC%PWY4FS-8 phosphatidylglycerol biosynthesis II (non-plastidic) GPD2 LPCAT3 GPAT2 CDS2 AGPAT5 CDS1 AGPAT6 AGPAT9 MBOAT2 ABHD5 AGPAT1 AGPAT2 LCLAT1 AGPAT3 AGPAT4 PGS1 GPAM LPCAT4 D-MYO< I>-INOSITOL (3,4,5,6)-TETRAKISPHOSPHATE BIOSYNTHESIS%HUMANCYC%PWY-6365 D-myo< i>-inositol (3,4,5,6)-tetrakisphosphate biosynthesis ITPK1 IPMK NADH REPAIR%HUMANCYC%PWY-6938 NADH repair GAPDH APOA1BP INOSINE-5'-PHOSPHATE BIOSYNTHESIS II%HUMANCYC%PWY-6124 inosine-5'-phosphate biosynthesis II ADSL ATIC PAICS PHENYLETHYLAMINE DEGRADATION I%HUMANCYC%2PHENDEG-PWY phenylethylamine degradation I AOC3 AOC2 ALDH3A2 ALDH2 DOLICHOL AND DOLICHYL PHOSPHATE BIOSYNTHESIS%HUMANCYC%PWY-6129 dolichol and dolichyl phosphate biosynthesis SRD5A3 DOLK DHDDS (S)-RETICULINE BIOSYNTHESIS II%HUMANCYC%PWY-6133 (S)-reticuline biosynthesis II TYR FATTY ACID &ALPHA;-OXIDATION II%HUMANCYC%PWY66-387 fatty acid α-oxidation II ACSBG1 ACSBG2 SLC27A2 ACSL1 ACSL5 PHYH ACSL4 ACSL6 HACL1 ACSL3 GUANOSINE NUCLEOTIDES DEGRADATION III%HUMANCYC%PWY-6608 guanosine nucleotides degradation III GDA PNP NT5C2 XDH METHYLGLYOXAL DEGRADATION I%HUMANCYC%PWY-5386 methylglyoxal degradation I GLO1 LDHD HAGH MITOCHONDRIAL L-CARNITINE SHUTTLE PATHWAY%HUMANCYC%PWY-6111 mitochondrial L-carnitine shuttle pathway CPT1A CPT2 CPT1C PYRIDOXAL 5'-PHOSPHATE SALVAGE PATHWAY%HUMANCYC%PLPSAL-PWY pyridoxal 5'-phosphate salvage pathway PNPO PDXK L-DOPA DEGRADATION%HUMANCYC%PWY-6334 L-dopa degradation COMT ETHANOL DEGRADATION IV%HUMANCYC%PWY66-162 ethanol degradation IV ACSS3 ALDH3A2 ACSS2 TYRP1 CAT ACSS1 ALDH2 URIDINE-5'-PHOSPHATE BIOSYNTHESIS%HUMANCYC%PWY-5686 uridine-5'-phosphate biosynthesis UMPS CAD CMP-N< I>-ACETYLNEURAMINATE BIOSYNTHESIS I (EUKARYOTES)%HUMANCYC%PWY-6138 CMP-N< i>-acetylneuraminate biosynthesis I (eukaryotes) NANP CMAS NANS GNE GLUTAMINE DEGRADATION I%HUMANCYC%GLUTAMINDEG-PWY glutamine degradation I GLS2 ASNS GLS METHYLMALONYL PATHWAY%HUMANCYC%PROPIONMET-PWY methylmalonyl pathway MCEE PCCA PCCB MUT SELENOCYSTEINE BIOSYNTHESIS II (ARCHAEA AND EUKARYOTES)%HUMANCYC%PWY-6281 selenocysteine biosynthesis II (archaea and eukaryotes) SEPHS1 PSTK SEPSECS SARS2 SARS GLYCEROL DEGRADATION I%HUMANCYC%PWY-4261 glycerol degradation I GK5 GK GK2 HEME BIOSYNTHESIS FROM UROPORPHYRINOGEN-III I%HUMANCYC%HEME-BIOSYNTHESIS-II heme biosynthesis from uroporphyrinogen-III I FECH UROD CPOX PPOX DERMATAN SULFATE BIOSYNTHESIS (LATE STAGES)%HUMANCYC%PWY-6568 dermatan sulfate biosynthesis (late stages) DSE UST CHST15 CHST14 ALANINE BIOSYNTHESIS III%HUMANCYC%PWY0-1021 alanine biosynthesis III NFS1 FOLATE POLYGLUTAMYLATION%HUMANCYC%PWY-2161 folate polyglutamylation SHMT1 FPGS MTHFD1 MTHFD1L SHMT2 KETOGENESIS%HUMANCYC%REACT_1464.NULL ketogenesis ACAA1 HMGCL BDH1 ACAT1 HMGCS2 HADHB OXIDIZED GTP AND DGTP DETOXIFICATION%HUMANCYC%PWY-6502 oxidized GTP and dGTP detoxification NUDT1 ZYMOSTEROL BIOSYNTHESIS%HUMANCYC%PWY-6074 zymosterol biosynthesis MSMO1 HSD17B7 LBR TM7SF2 NSDHL CYP51A1 N< I>-ACETYLGLUCOSAMINE DEGRADATION II%HUMANCYC%PWY-6517 N< i>-acetylglucosamine degradation II NAGK GNPDA1 GNPDA2 AMDHD2 LANOSTEROL BIOSYNTHESIS%HUMANCYC%PWY-6132 lanosterol biosynthesis LSS GLYCINE DEGRADATION (CREATINE BIOSYNTHESIS)%HUMANCYC%GLYCGREAT-PWY glycine degradation (creatine biosynthesis) GAMT GATM PHOSPHATIDYLCHOLINE BIOSYNTHESIS I%HUMANCYC%PWY3O-450 phosphatidylcholine biosynthesis I PCYT1B PCYT1A CHKB CHKA CHPT1 CEPT1 D-MANNOSE DEGRADATION%HUMANCYC%MANNCAT-PWY D-mannose degradation MPI 2-AMINO-3-CARBOXYMUCONATE SEMIALDEHYDE DEGRADATION TO GLUTARYL-COA%HUMANCYC%PWY-5652 2-amino-3-carboxymuconate semialdehyde degradation to glutaryl-CoA ACMSD INOSITOL PYROPHOSPHATES BIOSYNTHESIS%HUMANCYC%PWY-6369 inositol pyrophosphates biosynthesis IPPK IPMK IP6K1 IP6K3 IP6K2 PPIP5K1 PPIP5K2 GLUTARYL-COA DEGRADATION%HUMANCYC%PWY-5177 glutaryl-CoA degradation ACAA1 ACAT2 ACAT1 HADHB GCDH UDP-N< I>-ACETYL-D-GALACTOSAMINE BIOSYNTHESIS I%HUMANCYC%PWY-5512 UDP-N< i>-acetyl-D-galactosamine biosynthesis I GALE TRNA CHARGING%HUMANCYC%TRNA-CHARGING-PWY tRNA charging CARS AARS2 VARS TARSL2 PARS2 TARS EPRS YARS2 FARS2 NARS SARS2 LARS SARS RARS NARS2 IARS2 HARS EARS2 YARS RARS2 DARS WARS MARS2 DARS2 HARS2 WARS2 LARS2 KARS QARS MARS TARS2 GARS IARS FARSA CARS2 FARSB AARS DIPHTHAMIDE BIOSYNTHESIS%HUMANCYC%PWY-6482 diphthamide biosynthesis DPH5 CALCIUM TRANSPORT I%HUMANCYC%PWY-6166 calcium transport I ATP2A2 ATP2A1 ATP2C2 ATP2C1 ATP2A3 SUCROSE DEGRADATION V (MAMMALIAN)%HUMANCYC%PWY66-373 sucrose degradation V (mammalian) TPI1 SI GALM ALDOB ALDOA KHK 4-HYDROXYBENZOATE BIOSYNTHESIS%HUMANCYC%PWY-5754-1 4-hydroxybenzoate biosynthesis TAT S< I>-METHYL-5'-THIOADENOSINE DEGRADATION II%HUMANCYC%PWY-6756 S< i>-methyl-5'-thioadenosine degradation II MTAP ASPARAGINE BIOSYNTHESIS I%HUMANCYC%ASPARAGINE-BIOSYNTHESIS asparagine biosynthesis I ASNS 2-OXOBUTANOATE DEGRADATION I%HUMANCYC%PWY-5130 2-oxobutanoate degradation I MCEE PCCA PCCB MUT BCKDHA DBT BCKDHB DLD SPERMIDINE BIOSYNTHESIS I%HUMANCYC%BSUBPOLYAMSYN-PWY spermidine biosynthesis I AMD1 SRM DTMP DE NOVO< I> BIOSYNTHESIS%HUMANCYC%PWY66-385 dTMP de novo< i> biosynthesis SHMT1 DHFR TYMS SHMT2 ACETYL-COA BIOSYNTHESIS III (FROM CITRATE)%HUMANCYC%PWY-5172 acetyl-CoA biosynthesis III (from citrate) ACLY SUPERPATHWAY OF D-MYO< I>-INOSITOL (1,4,5)-TRISPHOSPHATE METABOLISM%HUMANCYC%PWY-6358 superpathway of D-myo< i>-inositol (1,4,5)-trisphosphate metabolism INPP5J INPP5K IPMK OCRL INPP1 ITPKB MINPP1 INPP5F ITPKC SYNJ2 SYNJ1 ITPKA PTEN INPPL1 IMPA1 IMPA2 IMPAD1 INPP5B INPP5A INPP5D TRIACYLGLYCEROL DEGRADATION%HUMANCYC%LIPAS-PWY triacylglycerol degradation MGLL PNLIPRP3 PNLIP PNPLA2 ABHD12 LIPF LIPE LIPC LIPG PNPLA3 PNPLA4 ABHD6 GLUCOSE AND GLUCOSE-1-PHOSPHATE DEGRADATION%HUMANCYC%GLUCOSE1PMETAB-PWY glucose and glucose-1-phosphate degradation HKDC1 PGM2 PGM5 GCK PGM1 CHOLESTEROL BIOSYNTHESIS I%HUMANCYC%PWY66-341 cholesterol biosynthesis I NSDHL CYP51A1 MSMO1 HSD17B7 LBR TM7SF2 DHCR24 SQLE EBP SC5D DHCR7 FDFT1 LSS HISTIDINE DEGRADATION III%HUMANCYC%PWY-5030 histidine degradation III AMDHD1 FTCD MTHFD1 MTHFD2 MTHFD2L HAL UROC1 TETRAHYDROBIOPTERIN BIOSYNTHESIS I%HUMANCYC%PWY-5663 tetrahydrobiopterin biosynthesis I GCH1 SPR PTS SPHINGOMYELIN METABOLISM%HUMANCYC%PWY3DJ-11281 sphingomyelin metabolism SMPD3 SMPD2 SMPD4 SAMD8 SMPD1 SGMS2 ENPP7 RAPOPORT-LUEBERING GLYCOLYTIC SHUNT%HUMANCYC%PWY-6405 Rapoport-Luebering glycolytic shunt MINPP1 PGAM1 PGAM2 BPGM D-GLUCURONATE DEGRADATION I%HUMANCYC%PWY-5525 D-glucuronate degradation I CRYL1 DCXR NORADRENALINE AND ADRENALINE DEGRADATION%HUMANCYC%PWY-6342 noradrenaline and adrenaline degradation COMT PNMT ADH4 LRTOMT ALDH3A2 ADH1B ADH6 MAOB MAOA ALDH2 ARGININE DEGRADATION I (ARGINASE PATHWAY)%HUMANCYC%ARGASEDEG-PWY arginine degradation I (arginase pathway) ARG2 OAT ARG1 ALDH4A1 PHOSPHOLIPASES%HUMANCYC%LIPASYN-PWY phospholipases PLA2G16 PLCG2 PLA2G10 PLCG1 PLCH1 PLCH2 PLCD3 PLCD4 PLCD1 PLCZ1 PLCE1 PLA2G1B PLCB3 PLA2G3 PLCB4 PLD4 PLD6 PLA2G5 PLD1 PLCB1 PLA2G6 PLCB2 PLD3 PLB1 PLD2 OC90 PLA2G2F PLA2G12A PLA2G2D PLA2G4F PLA2G2E PLA2G4D PNPLA8 PLA2G2A PLA2G4C PLA2G4A D-MYO< I>-INOSITOL (1,4,5)-TRISPHOSPHATE DEGRADATION%HUMANCYC%PWY-6363 D-myo< i>-inositol (1,4,5)-trisphosphate degradation INPP5J INPP5K OCRL INPP1 INPP5F SYNJ2 SYNJ1 INPPL1 IMPA1 IMPA2 IMPAD1 INPP5B INPP5A ADENINE AND ADENOSINE SALVAGE VI%HUMANCYC%PWY-6619 adenine and adenosine salvage VI ADK KETOLYSIS%HUMANCYC%REACT_59.NULL ketolysis ACAA1 BDH1 ACAT1 BDH2 OXCT1 HADHB NAD PHOSPHORYLATION AND DEPHOSPHORYLATION%HUMANCYC%NADPHOS-DEPHOS-PWY NAD phosphorylation and dephosphorylation NNT ACP6 PXYLP1 NADK NAD BIOSYNTHESIS FROM 2-AMINO-3-CARBOXYMUCONATE SEMIALDEHYDE%HUMANCYC%PWY-5653 NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde NMNAT1 QPRT NMNAT3 NMNAT2 NADSYN1 L-CYSTEINE DEGRADATION II%HUMANCYC%LCYSDEG-PWY L-cysteine degradation II CTH DOPAMINE DEGRADATION%HUMANCYC%PWY6666-2 dopamine degradation COMT ALDH3A2 MAOB MAOA SULT1A1 SULT1A2 UREA CYCLE%HUMANCYC%PWY-4984 urea cycle ARG2 ARG1 CPS1 ASL ASS1 OTC GERANYLGERANYLDIPHOSPHATE BIOSYNTHESIS%HUMANCYC%PWY-5120 geranylgeranyldiphosphate biosynthesis GGPS1 3-PHOSPHOINOSITIDE DEGRADATION%HUMANCYC%PWY-6368 3-phosphoinositide degradation INPP5J INPP5K SACM1L OCRL INPP5F SYNJ2 SYNJ1 TPTE2 INPP4A INPP4B TMEM55A MTMR14 PTPMT1 PTEN INPP5E TMEM55B INPPL1 PMPCA MTMR3 INPP5B INPP5D ANANDAMIDE DEGRADATION%HUMANCYC%PWY6666-1 anandamide degradation FAAH FAAH2 PENTOSE PHOSPHATE PATHWAY%HUMANCYC%PENTOSE-P-PWY pentose phosphate pathway RPIA TKTL2 TKTL1 G6PD H6PD RPE TALDO1 PGLS PGD TKT ALL-TRANS< I>-DECAPRENYL DIPHOSPHATE BIOSYNTHESIS%HUMANCYC%PWY-5806 all-trans< i>-decaprenyl diphosphate biosynthesis PDSS2 PDSS1 OXIDATIVE ETHANOL DEGRADATION III%HUMANCYC%PWY66-161 oxidative ethanol degradation III ACSS3 ALDH3A2 ACSS2 CYP2E1 ACSS1 ALDH2 HEME BIOSYNTHESIS II%HUMANCYC%PWY-5920 heme biosynthesis II ALAD ALAS2 ALAS1 UROS FECH HMBS UROD CPOX PPOX L-CYSTEINE DEGRADATION I%HUMANCYC%CYSTEINE-DEG-PWY L-cysteine degradation I GOT1 CDO1 GDP-GLUCOSE BIOSYNTHESIS%HUMANCYC%PWY-5661 GDP-glucose biosynthesis HKDC1 PGM2 PGM5 GCK PGM1 TRYPTOPHAN DEGRADATION TO 2-AMINO-3-CARBOXYMUCONATE SEMIALDEHYDE%HUMANCYC%PWY-5651 tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde KYNU AFMID KMO TDO2 HAAO EUMELANIN BIOSYNTHESIS%HUMANCYC%PWY-6498 eumelanin biosynthesis DCT TRPC1 TYR TYRP1 URATE BIOSYNTHESIS INOSINE 5'-PHOSPHATE DEGRADATION%HUMANCYC%PWY-5695 urate biosynthesis inosine 5'-phosphate degradation NT5C3B NT5E PNP IMPDH1 IMPDH2 NT5C2 XDH SPERMINE AND SPERMIDINE DEGRADATION I%HUMANCYC%PWY-6117 spermine and spermidine degradation I AOC3 SAT2 SAT1 SMOX PAOX URACIL DEGRADATION II (REDUCTIVE)%ARACYC%PWY-3982 uracil degradation II (reductive) DPYSL5 DPYSL2 DPYS DPYSL3 DPYD CRMP1 UPB1 DPYSL4 5-AMINOIMIDAZOLE RIBONUCLEOTIDE BIOSYNTHESIS I%HUMANCYC%PWY-6121 5-aminoimidazole ribonucleotide biosynthesis I PPAT GART PFAS SEROTONIN AND MELATONIN BIOSYNTHESIS%HUMANCYC%PWY-6030 serotonin and melatonin biosynthesis TPH1 AANAT ASMT DDC TPH2 ACYL-COA HYDROLYSIS%HUMANCYC%PWY-5148 acyl-CoA hydrolysis ACOT9 ACOT8 ACOT7 HISTAMINE DEGRADATION%HUMANCYC%PWY-6181 histamine degradation AOC2 AOC1 HNMT ALANINE DEGRADATION III%HUMANCYC%ALANINE-DEG3-PWY alanine degradation III GPT2 GPT ALANINE BIOSYNTHESIS II%HUMANCYC%ALANINE-SYN2-PWY alanine biosynthesis II GPT2 GPT MAP KINASE CASCADE%HUMANCYC%REACT_634.NULL MAP kinase cascade YWHAB BMP SIGNALLING PATHWAY%HUMANCYC%REACT_12034.NULL BMP Signalling Pathway SKI SMAD4 BMP2 UBE2D3 UBE2D1 CHOLINE BIOSYNTHESIS III%HUMANCYC%PWY-3561 choline biosynthesis III PLD1 PLD3 PLD2 PCYT1B PCYT1A CHPT1 PLD4 CEPT1 PLD6 TETRAPYRROLE BIOSYNTHESIS II%HUMANCYC%PWY-5189 tetrapyrrole biosynthesis II ALAD ALAS2 ALAS1 UROS HMBS LEUKOTRIENE BIOSYNTHESIS%HUMANCYC%15354 leukotriene biosynthesis ALOX5 DPEP2 DPEP1 LTA4H LTC4S GGT2 FLAVIN BIOSYNTHESIS IV (MAMMALIAN)%HUMANCYC%11070 flavin biosynthesis IV (mammalian) FLAD1 RFK GLYCOGEN DEGRADATION II%HUMANCYC%PWY-5941 glycogen degradation II PYGB AGL PYGM PYGL PGM2 PGM5 PGM1 4-HYDROXYPROLINE DEGRADATION I%HUMANCYC%HYDROXYPRODEG-PWY 4-hydroxyproline degradation I ALDH4A1 TRANS, TRANS< I>-FARNESYL DIPHOSPHATE BIOSYNTHESIS%HUMANCYC%PWY-5123 trans, trans< i>-farnesyl diphosphate biosynthesis IDI1 IDI2 FDPS GGPS1 L-GLUTAMINE BIOSYNTHESIS II (TRNA-DEPENDENT)%HUMANCYC%PWY-5921 L-glutamine biosynthesis II (tRNA-dependent) GATB QRSL1 OLEATE BIOSYNTHESIS II (ANIMALS)%HUMANCYC%PWY-5996 oleate biosynthesis II (animals) ACOT2 FADS2 ACOT1 SCD SCD5 FADS1 ACOT4 PYRUVATE FERMENTATION TO LACTATE%HUMANCYC%PWY-5481 pyruvate fermentation to lactate LDHC LDHB LDHA LDHAL6A LDHAL6B D-MYO< I>-INOSITOL (1,4,5)-TRISPHOSPHATE BIOSYNTHESIS%HUMANCYC%PWY-6351 D-myo< i>-inositol (1,4,5)-trisphosphate biosynthesis PLCE1 PLCG2 PIP4K2A PIP5K1A PIP4K2B PIP4K2C PIP5K1B PLCG1 PIP5K1C CDIPT PLCB3 PLCB4 PLCH1 PLCH2 PLCB1 PI4KB PLCB2 PI4K2B PLCD3 PI4K2A PLCD4 PLCD1 PLCZ1 PIP5KL1 GLUTATHIONE-MEDIATED DETOXIFICATION I%HUMANCYC%PWY-4061 glutathione-mediated detoxification I GSTM4 GSTK1 GSTM3 GSTM2 GGT7 GGT6 GSTM1 GSTO2 MGST3 GSTP1 MGST1 MGST2 GGH GSTT1 GSTZ1 GSTA5 GSTA4 GSTA3 GSTA2 ANPEP GSTA1 GGT1 GSTM5 LYSINE DEGRADATION II%HUMANCYC%LYSINE-DEG1-PWY lysine degradation II SCCPDH ALDH7A1 AASS PROLINE BIOSYNTHESIS I%HUMANCYC%PROSYN-PWY proline biosynthesis I PYCRL PYCR1 PYCR2 ALDH18A1 FATTY ACID &BETA;-OXIDATION I%HUMANCYC%FAO-PWY fatty acid β-oxidation I ACSL1 ACSL5 HADHB ACSL4 ACSL3 ACSBG1 ACAA1 ACSBG2 SLC27A2 ACAA2 ECHS1 ECI1 ECI2 HSD17B10 HADHA EHHADH HADH ACSL6 UDP-N< I>-ACETYL-D-GLUCOSAMINE BIOSYNTHESIS II%HUMANCYC%UDPNACETYLGALSYN-PWY UDP-N< i>-acetyl-D-glucosamine biosynthesis II GFPT2 GFPT1 PGM3 GNPNAT1 UAP1 CDP-DIACYLGLYCEROL BIOSYNTHESIS I%HUMANCYC%PWY-5667 CDP-diacylglycerol biosynthesis I GPD2 LPCAT3 GPAT2 CDS2 AGPAT5 CDS1 AGPAT6 AGPAT9 MBOAT2 ABHD5 AGPAT1 AGPAT2 LCLAT1 AGPAT3 AGPAT4 GPAM LPCAT4 PUTRESCINE BIOSYNTHESIS III%HUMANCYC%PWY-46 putrescine biosynthesis III ODC1 AZIN2 COLANIC ACID BUILDING BLOCKS BIOSYNTHESIS%HUMANCYC%COLANSYN-PWY colanic acid building blocks biosynthesis MPI GALE GPI TSTA3 GALT PMM1 PMM2 GMPPB UGDH UGP2 GMDS GMPPA GALK1 GDP-L-FUCOSE BIOSYNTHESIS I (FROM GDP-D-MANNOSE)%HUMANCYC%PWY-66 GDP-L-fucose biosynthesis I (from GDP-D-mannose) TSTA3 GMDS SALVAGE PATHWAYS OF PYRIMIDINE DEOXYRIBONUCLEOTIDES%HUMANCYC%PWY0-181 salvage pathways of pyrimidine deoxyribonucleotides CDA TK2 TK1 AICDA TYMP D-MYO< I>-INOSITOL (1,4,5,6)-TETRAKISPHOSPHATE BIOSYNTHESIS%HUMANCYC%PWY-6366 D-myo< i>-inositol (1,4,5,6)-tetrakisphosphate biosynthesis ITPK1 IPMK MINPP1 1,25-DIHYDROXYVITAMIN D3< SUB> BIOSYNTHESIS%HUMANCYC%PWY-6076 1,25-dihydroxyvitamin D3< sub> biosynthesis CYP27B1 POR CYP2R1 GALACTOSE DEGRADATION I (LELOIR PATHWAY)%HUMANCYC%PWY-6317 galactose degradation I (Leloir pathway) GALE GALT GALM GALK1 THIOSULFATE DISPROPORTIONATION III (RHODANESE)%HUMANCYC%PWY-5350 thiosulfate disproportionation III (rhodanese) TST METHYLTHIOPROPIONATE BIOSYNTHESIS%HUMANCYC%PWY-5389 methylthiopropionate biosynthesis ADI1 SUPERPATHWAY OF SERINE AND GLYCINE BIOSYNTHESIS I%HUMANCYC%SER-GLYSYN-PWY superpathway of serine and glycine biosynthesis I SHMT1 PSPH PSAT1 SHMT2 PHGDH NAD SALVAGE PATHWAY III%HUMANCYC%PWY3O-4106 NAD salvage pathway III NMNAT1 NMRK2 NMRK1 NMNAT3 NMNAT2 CHONDROITIN SULFATE DEGRADATION (METAZOA)%HUMANCYC%PWY-6573 chondroitin sulfate degradation (metazoa) HYAL4 SPAM1 ARSB GALNS HYAL1 HEXA L-DOPACHROME BIOSYNTHESIS%HUMANCYC%PWY-6481 L-dopachrome biosynthesis TYR GLUCONEOGENESIS I%HUMANCYC%GLUCONEO-PWY gluconeogenesis I FBP2 GAPDH ALDOB ALDOA MDH1 MDH2 ENO1 GPI ENO2 ENO3 VCAN ME1 GAPDHS PGAM1 PGK1 PGAM2 ME3 BPGM ME2 PGK2 PCK1 FBP1 GLUTAMATE DEPENDENT ACID RESISTANCE%HUMANCYC%PWY0-1305 glutamate dependent acid resistance GAD1 GAD2 1D-MYO< I>-INOSITOL HEXAKISPHOSPHATE BIOSYNTHESIS V (FROM INS(1,3,4)P3)%HUMANCYC%PWY-6554 1D-myo< i>-inositol hexakisphosphate biosynthesis V (from Ins(1,3,4)P3) IPPK ITPK1 IPMK GLYCINE BIOSYNTHESIS III%HUMANCYC%GLYSYN-ALA-PWY glycine biosynthesis III AGXT2 AGXT TYROSINE BIOSYNTHESIS IV%HUMANCYC%PWY-6134 tyrosine biosynthesis IV PAH ADENOSINE NUCLEOTIDES DEGRADATION II%HUMANCYC%SALVADEHYPOX-PWY adenosine nucleotides degradation II NT5C3A NT5E PNP NT5C1A NT5C2 XDH ADA GLUTAMATE DEGRADATION II%HUMANCYC%GLUTDEG-PWY glutamate degradation II GOT1L1 GOT1 GOT2 CARDIOLIPIN BIOSYNTHESIS II%HUMANCYC%PWY-5269 cardiolipin biosynthesis II CRLS1 PGS1 THIAMIN SALVAGE III%HUMANCYC%PWY-6898 thiamin salvage III TPK1 DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE BIOSYNTHESIS%HUMANCYC%MANNOSYL-CHITO-DOLICHOL-BIOSYNTHESIS dolichyl-diphosphooligosaccharide biosynthesis DPM1 DPAGT1 ALG8 DPM3 ALG6 ALG5 ALG13 ALG3 ALG1 FATTY ACID BIOSYNTHESIS INITIATION II%HUMANCYC%PWY-5966 fatty acid biosynthesis initiation II SLC35G3 OXSM FASN GLUTAMATE BIOSYNTHESIS II%HUMANCYC%GLUTAMATE-SYN2-PWY glutamate biosynthesis II GLUD1 GLUD2 TAURINE BIOSYNTHESIS%HUMANCYC%PWY-5331 taurine biosynthesis CSAD CDO1 FATTY ACID ACTIVATION%HUMANCYC%PWY-5143 fatty acid activation ACSBG1 ACSBG2 SLC27A2 ACSL1 ACSL5 ACSL4 ACSL6 ACSL3 S< I>-METHYL-5-THIO-&ALPHA;-D-RIBOSE 1-PHOSPHATE DEGRADATION%HUMANCYC%PWY-6755 S< i>-methyl-5-thio-α-D-ribose 1-phosphate degradation ENOPH1 ADI1 APIP MRI1 PENTOSE PHOSPHATE PATHWAY (OXIDATIVE BRANCH)%HUMANCYC%OXIDATIVEPENT-PWY pentose phosphate pathway (oxidative branch) G6PD H6PD PGLS PGD FATTY ACID &ALPHA;-OXIDATION III%HUMANCYC%PWY66-388 fatty acid α-oxidation III ALDH3A2 HACL1 ADENINE AND ADENOSINE SALVAGE III%HUMANCYC%PWY-6609 adenine and adenosine salvage III HPRT1 PNP ADA CATECHOLAMINE BIOSYNTHESIS%HUMANCYC%PWY66-301 catecholamine biosynthesis PNMT DDC THYMINE DEGRADATION%HUMANCYC%PWY-6430 thymine degradation DPYSL5 DPYSL2 DPYS DPYSL3 DPYD CRMP1 UPB1 DPYSL4 4-HYDROXY-2-NONENAL DETOXIFICATION%HUMANCYC%PWY-7112 4-hydroxy-2-nonenal detoxification GSTP1 GSTA5 GSTA4 GSTA3 GSTA1 THIO-MOLYBDENUM COFACTOR BIOSYNTHESIS%HUMANCYC%PWY-5963 thio-molybdenum cofactor biosynthesis MOCOS NAD BIOSYNTHESIS III%HUMANCYC%NAD-BIOSYNTHESIS-III NAD biosynthesis III NMNAT1 NAMPT NMNAT3 NMNAT2 COENZYME A BIOSYNTHESIS%HUMANCYC%COA-PWY coenzyme A biosynthesis PPCS COASY PPCDC GLYCOLYSIS I%HUMANCYC%GLYCOLYSIS glycolysis I FBP2 PKLR PFKL PKM PFKM GAPDH PFKP TPI1 ALDOB ALDOA ENO1 GPI ENO2 ENO3 VCAN GAPDHS PGAM1 PGK1 PGAM2 BPGM PGK2 FBP1 N< I>-ACETYLGLUCOSAMINE DEGRADATION I%HUMANCYC%GLUAMCAT-PWY N< i>-acetylglucosamine degradation I GNPDA1 GNPDA2 AMDHD2 3-PHOSPHOINOSITIDE BIOSYNTHESIS%HUMANCYC%PWY-6352 3-phosphoinositide biosynthesis PIP5K1A PIP5K1B PIP5K1C CDIPT FIG4 PIKFYVE PI4KB PI4K2B PIK3CD PIK3C2G PIK3CB PIK3C2A PIK3CG PIK3C2B PIP5KL1 PIP4K2B SACM1L PIK3CA PIK3C3 PI4K2A PIK3R4 PIK3R3 PIK3R2 PIK3R1 PIK3R6 PIK3R5 UDP-N< I>-ACETYL-D-GALACTOSAMINE BIOSYNTHESIS II%HUMANCYC%PWY-5514 UDP-N< i>-acetyl-D-galactosamine biosynthesis II GALE PGM3 GPI GNPNAT1 UAP1 GNPDA1 HKDC1 GNPDA2 GCK PHOSPHATIDYLETHANOLAMINE BIOSYNTHESIS III%HUMANCYC%PWY-6273 phosphatidylethanolamine biosynthesis III PTDSS2 SUPERPATHWAY OF GERANYLGERANYLDIPHOSPHATE BIOSYNTHESIS I (VIA MEVALONATE)%HUMANCYC%PWY-5910 superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate) IDI1 MVK HMGCS1 IDI2 PMVK MVD HMGCR HMGCS2 GGPS1 HADHB ACAA1 ACAT2 ACAT1 FDPS SORBITOL DEGRADATION I%HUMANCYC%PWY-4101 sorbitol degradation I SORD THYROID HORMONE BIOSYNTHESIS%HUMANCYC%PWY-6241 thyroid hormone biosynthesis TPO CTSD 4-AMINOBUTYRATE DEGRADATION I%HUMANCYC%PWY-6535 4-aminobutyrate degradation I ALDH5A1 ABAT GUANINE AND GUANOSINE SALVAGE I%HUMANCYC%PWY-6620 guanine and guanosine salvage I HPRT1 PNP FORMALDEHYDE OXIDATION II (GLUTATHIONE-DEPENDENT)%ECOCYC%PWY-1801 formaldehyde oxidation II (glutathione-dependent) ESD ADH5 LACTOSE DEGRADATION III%HUMANCYC%BGALACT-PWY lactose degradation III GLB1 ETHANOL DEGRADATION II%HUMANCYC%PWY66-21 ethanol degradation II ACSS3 ALDH3A2 ACSS2 ADH1B ACSS1 ALDH2 GLUTAMINE BIOSYNTHESIS I%HUMANCYC%GLNSYN-PWY glutamine biosynthesis I GLUL SPHINGOSINE AND SPHINGOSINE-1-PHOSPHATE METABOLISM%HUMANCYC%PWY3DJ-11470 sphingosine and sphingosine-1-phosphate metabolism ACER2 ACER1 ASAH1 ASAH2 SPHK2 SPHK1 PTGR1 SGPP2 SGPP1 CITRULLINE DEGRADATION%HUMANCYC%CITRULLINE-DEG-PWY citrulline degradation OTC S-ADENOSYL-L-METHIONINE BIOSYNTHESIS%HUMANCYC%SAM-PWY S-adenosyl-L-methionine biosynthesis MAT2A MAT1A MAT2B SPERMINE BIOSYNTHESIS%HUMANCYC%ARGSPECAT-PWY spermine biosynthesis SMS AMD1 GLUTATHIONE REDOX REACTIONS I%HUMANCYC%PWY-4081 glutathione redox reactions I GPX4 GPX3 GPX6 GSR GPX5 GPX8 GPX7 GPX2 GPX1 NAD SALVAGE PATHWAY II%HUMANCYC%NAD-BIOSYNTHESIS-II NAD salvage pathway II NMNAT1 NMRK2 NMRK1 NT5C3B NMNAT3 NT5E NMNAT2 ENPP1 ENPP3 NUDT12 ACP6 PXYLP1 ASPARAGINE DEGRADATION I%HUMANCYC%ASPARAGINE-DEG1-PWY asparagine degradation I ASRGL1 ASPG PRPP BIOSYNTHESIS I%HUMANCYC%PWY0-662 PRPP biosynthesis I PRPS2 PRPS1 CHOLESTEROL BIOSYNTHESIS III (VIA DESMOSTEROL)%HUMANCYC%PWY66-4 cholesterol biosynthesis III (via desmosterol) NSDHL CYP51A1 MSMO1 HSD17B7 LBR TM7SF2 DHCR24 SQLE EBP SC5D DHCR7 FDFT1 LSS ASPARTATE DEGRADATION II%HUMANCYC%MALATE-ASPARTATE-SHUTTLE-PWY aspartate degradation II MDH1 MDH2 GOT1L1 GOT1 GOT2 PROLINE BIOSYNTHESIS II (FROM ARGININE)%HUMANCYC%PWY-4981 proline biosynthesis II (from arginine) OAT OTC PYCRL PYCR1 PYCR2 GLUTAMATE DEGRADATION III (VIA 4-AMINOBUTYRATE)%HUMANCYC%GLUDEG-I-PWY glutamate degradation III (via 4-aminobutyrate) ALDH5A1 ABAT GAD1 GAD2 PHOSPHATIDYLETHANOLAMINE BIOSYNTHESIS II%HUMANCYC%PWY4FS-6 phosphatidylethanolamine biosynthesis II PCYT2 CHKB ETNK2 ETNK1 EPT1 CEPT1 PENTOSE PHOSPHATE PATHWAY (NON-OXIDATIVE BRANCH)%HUMANCYC%NONOXIPENT-PWY pentose phosphate pathway (non-oxidative branch) RPIA TKTL2 TKTL1 RPE TALDO1 TKT FATTY ACID &BETA;-OXIDATION III (UNSATURATED, ODD NUMBER)%HUMANCYC%PWY-5137 fatty acid β-oxidation III (unsaturated, odd number) ECI1 ECI2 EHHADH GLUTAMATE REMOVAL FROM FOLATES%HUMANCYC%PWY-2161B glutamate removal from folates GGH D-MYO< I>-INOSITOL (1,3,4)-TRISPHOSPHATE BIOSYNTHESIS%HUMANCYC%PWY-6364 D-myo< i>-inositol (1,3,4)-trisphosphate biosynthesis INPP5J INPP5K IPMK OCRL ITPKB MINPP1 ITPKC SYNJ2 SYNJ1 ITPKA PTEN INPPL1 INPP5B INPP5A INPP5D NAD BIOSYNTHESIS II (FROM TRYPTOPHAN)%HUMANCYC%NADSYN-PWY NAD biosynthesis II (from tryptophan) KYNU AFMID KMO NMNAT1 QPRT NMNAT3 NMNAT2 NADSYN1 TDO2 HAAO PURINE NUCLEOTIDES DE NOVO< I> BIOSYNTHESIS II%HUMANCYC%PWY-841 purine nucleotides de novo< i> biosynthesis II ADSSL1 GMPS ADSS PPAT IMPDH1 GART PFAS ADSL IMPDH2 ATIC PAICS TRIACYLGLYCEROL BIOSYNTHESIS%HUMANCYC%TRIGLSYN-PWY triacylglycerol biosynthesis LPCAT3 GPAT2 DGAT2 MOGAT3 DGAT1 AGPAT5 MOGAT1 PPAP2C AGPAT6 PPAP2B AGPAT9 PPAP2A MBOAT2 PPAPDC1A ABHD5 AGPAT1 AGPAT2 LCLAT1 AGPAT3 AGPAT4 GPAM LPCAT4 GLUTATHIONE BIOSYNTHESIS%HUMANCYC%GLUTATHIONESYN-PWY glutathione biosynthesis GCLC GSS GCLM PYRIMIDINE RIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%HUMANCYC%PWY0-162 pyrimidine ribonucleotides de novo< i> biosynthesis UMPS CANT1 NME2 CTPS2 NME3 CTPS1 NME4 NME5 NME1 NME6 NME7 CMPK1 CMPK2 CAD SALVAGE PATHWAYS OF PYRIMIDINE RIBONUCLEOTIDES%HUMANCYC%PWY0-163 salvage pathways of pyrimidine ribonucleotides UPP2 UPP1 CDA AICDA NME2 NME3 NME4 NME5 NME1 NME6 NME7 UCKL1 UCK2 UCK1 UPRT SUPERPATHWAY OF CHOLESTEROL BIOSYNTHESIS%HUMANCYC%PWY66-5 superpathway of cholesterol biosynthesis HADHB NSDHL CYP51A1 MSMO1 HSD17B7 ACAA1 LBR TM7SF2 ACAT2 DHCR24 ACAT1 SQLE EBP SC5D DHCR7 FDFT1 LSS IDI1 MVK HMGCS1 IDI2 PMVK MVD HMGCR HMGCS2 GGPS1 FDPS GDP-MANNOSE BIOSYNTHESIS%HUMANCYC%PWY-5659 GDP-mannose biosynthesis GPI PMM1 PMM2 GMPPB GMPPA MPI CYSTEINE BIOSYNTHESIS HOMOCYSTEINE DEGRADATION%HUMANCYC%HOMOCYSDEGR-PWY cysteine biosynthesis homocysteine degradation CBS CTH ARGININE DEGRADATION VI (ARGINASE 2 PATHWAY)%HUMANCYC%ARG-PRO-PWY arginine degradation VI (arginase 2 pathway) ARG2 OAT ARG1 PYCRL PYCR1 PYCR2 4-HYDROXYPHENYLPYRUVATE BIOSYNTHESIS%HUMANCYC%PWY-5886 4-hydroxyphenylpyruvate biosynthesis TAT SEROTONIN DEGRADATION%HUMANCYC%PWY-6313 serotonin degradation UGT2B10 ALDH3A2 ADH1B ADH6 MAOB MAOA SULT1A1 ALDH2 SULT1A2 L-CARNITINE BIOSYNTHESIS%HUMANCYC%PWY-6100 L-carnitine biosynthesis TMLHE BBOX1 ALDH9A1 &BETA;-ALANINE DEGRADATION I%HUMANCYC%BETA-ALA-DEGRADATION-I-PWY β-alanine degradation I ABAT ALDH6A1 DERMATAN SULFATE DEGRADATION (METAZOA)%HUMANCYC%PWY-6576 dermatan sulfate degradation (metazoa) IDUA SPAM1 HYAL1 HEXA TRNA SPLICING%HUMANCYC%PWY-6689 tRNA splicing TSEN34 TSEN15 TRPT1 TSEN2 TSEN54 EPOXYSQUALENE BIOSYNTHESIS%HUMANCYC%PWY-5670 epoxysqualene biosynthesis SQLE FDFT1 CREATINE-PHOSPHATE BIOSYNTHESIS%HUMANCYC%PWY-6158 creatine-phosphate biosynthesis CKMT2 CKM CKMT1A CKMT1B CKB GLYCEROL-3-PHOSPHATE SHUTTLE%HUMANCYC%PWY-6118 glycerol-3-phosphate shuttle GPD2 GPD1 GLUTAMATE DEGRADATION X%HUMANCYC%PWY-5766 glutamate degradation X GLUD1 GLUD2 PURINE RIBONUCLEOSIDES DEGRADATION TO RIBOSE-1-PHOSPHATE%HUMANCYC%PWY0-1296 purine ribonucleosides degradation to ribose-1-phosphate PNP ADA &ALPHA;-TOCOPHEROL DEGRADATION%HUMANCYC%PWY-6377 α-tocopherol degradation CYP4F2 TYROSINE DEGRADATION I%HUMANCYC%TYRFUMCAT-PWY tyrosine degradation I TAT GSTZ1 HGD FAH HPD THREONINE DEGRADATION II%HUMANCYC%THREONINE-DEG2-PWY threonine degradation II GCAT ACYL CARRIER PROTEIN METABOLISM%HUMANCYC%PWY-6012 acyl carrier protein metabolism AASDHPPT ARGININE BIOSYNTHESIS IV%HUMANCYC%ARGININE-SYN4-PWY arginine biosynthesis IV OAT ASL ASS1 GLUD1 OTC GLUD2 TREHALOSE DEGRADATION II (TREHALASE)%HUMANCYC%PWY0-1182 trehalose degradation II (trehalase) TREH HKDC1 GALM GCK TETRAHYDROBIOPTERIN BIOSYNTHESIS II%HUMANCYC%PWY-5664 tetrahydrobiopterin biosynthesis II GCH1 SPR PTS &GAMMA;-GLUTAMYL CYCLE%HUMANCYC%PWY-4041 γ-glutamyl cycle GGT2 GGCT GCLC DPP8 ANPEP GSS GGT7 GCLM OPLAH GGT6 GGT1 CNDP2 SUPEROXIDE RADICALS DEGRADATION%HUMANCYC%DETOX1-PWY superoxide radicals degradation SOD2 SOD3 SOD1 TYRP1 CAT ACETATE CONVERSION TO ACETYL-COA%HUMANCYC%PWY0-1313 acetate conversion to acetyl-CoA ACSS3 ACSS2 ACSS1 L-CYSTEINE DEGRADATION III%HUMANCYC%PWY-5329 L-cysteine degradation III MPST PYRIMIDINE RIBONUCLEOTIDES INTERCONVERSION%HUMANCYC%PWY-5687 pyrimidine ribonucleotides interconversion NME5 NME1 NME6 NME7 CMPK1 CMPK2 CANT1 NME2 CTPS2 NME3 CTPS1 NME4 1D-MYO< I>-INOSITOL HEXAKISPHOSPHATE BIOSYNTHESIS II (MAMMALIAN)%HUMANCYC%PWY-6362 1D-myo< i>-inositol hexakisphosphate biosynthesis II (mammalian) INPP5J INPP5K ITPK1 IPMK OCRL ITPKB ITPKC SYNJ2 SYNJ1 ITPKA IPPK INPPL1 INPP5B INPP5A INPP5D CHOLESTEROL BIOSYNTHESIS II (VIA 24,25-DIHYDROLANOSTEROL)%HUMANCYC%PWY66-3 cholesterol biosynthesis II (via 24,25-dihydrolanosterol) NSDHL CYP51A1 MSMO1 HSD17B7 LBR TM7SF2 DHCR24 SQLE EBP SC5D DHCR7 FDFT1 LSS MOLYBDENUM COFACTOR BIOSYNTHESIS%HUMANCYC%PWY-6823 molybdenum cofactor biosynthesis NFS1 MOCS2 MOCS3 GPHN SULFATE ACTIVATION FOR SULFONATION%HUMANCYC%PWY-5340 sulfate activation for sulfonation PAPSS1 PAPSS2 GLYCINE BIOSYNTHESIS I%HUMANCYC%GLYSYN-PWY glycine biosynthesis I SHMT1 SHMT2 METHYLGLYOXAL DEGRADATION VI%HUMANCYC%MGLDLCTANA-PWY methylglyoxal degradation VI LDHD CERAMIDE DEGRADATION%HUMANCYC%PWY-6483 ceramide degradation ASAH2 GLYCOGEN DEGRADATION III%HUMANCYC%PWY-5767 glycogen degradation III PYGB MGAM AGL GAA PYGM PYGL PGM2 PGM5 PGM1 CITRULLINE-NITRIC OXIDE CYCLE%HUMANCYC%PWY-4983 citrulline-nitric oxide cycle ASL ASS1 NOS2 NOS3 NOS1 ALPHA6BETA4INTEGRIN%IOB%ALPHA6BETA4INTEGRIN Alpha6Beta4Integrin LAMB1 PTPN11 PTK2 MTOR EIF6 GRB2 VIM TP73 YWHAE RTKN IRS1 YWHAB ITGB4 PIK3CD LAMC2 IRS2 PIK3CB LAMC1 MYLK3 PIK3CG YWHAQ CASP3 AKT1 RAC1 EPHB2 YWHAH DSP DST PRKCD RPSA PRKCA YWHAZ RHOA ERBB2IP AR PIK3CA ITGA6 MET PLEC COL17A1 LAMA5 CD151 LAMA2 SHC1 LAMA1 SRC LAMA3 PIK3R3 PIK3R2 MST1R PIK3R1 NTN1 EGFR PAK1 ERBB2 EIF4EBP1 CLCA2 ABL1 CLCA1 FYN SFN EIF4E SMAD2 YES1 SMAD3 LAMB3 BAD LAMB2 ANDROGENRECEPTOR%IOB%ANDROGENRECEPTOR AndrogenReceptor PAK6 SRY SPDEF SVIL GSN STAT3 RANBP9 GTF2H1 CDK11B PNRC1 HIPK3 PPP1CA CTNNB1 STUB1 VIP RAN FOXA1 RB1 CCNH PARK7 AHR NR3C1 UXT CCND3 KAT5 CCND1 ZMIZ1 ZMIZ2 EP300 AKT1 KAT7 PIAS4 PIAS3 DAXX DAPK3 GTF2F1 GTF2F2 PIAS2 RUNX2 CDC25A PIAS1 CDC25B RUNX1 AR CCNE1 CDC37 PRKD1 RAD54L2 IL6ST SF1 PXN PIK3R1 FOXO1 HSP90B1 BRINP1 PRDX1 BAG1 LPXN MAGEA11 PATZ1 HSPA8 SMAD4 JUN XRCC6 SMAD3 POU2F1 UBE2I HSPA5 XRCC5 NONO CAV1 PA2G4 ESR1 NR0B2 GNB2L1 CDK9 CDK7 SP1 MDM2 TCF4 CALR RBAK GSK3B RNF14 TGFB1I1 PTEN FHL2 HSPB1 BRCA1 EFCAB6 CASP7 CASP8 SIN3A CASP3 CASP1 TRIM68 RAC3 NELFCD WHSC1 PELP1 APPL1 TGIF1 NCOA1 NCOA2 HSP90AA1 PARP1 PRMT1 NCOA6 NCOA3 NCOA4 ARNT ETV5 SENP1 AES NCOR2 KAT2B TOP1 SLC25A4 GAPDH CEBPA DDC TMF1 HDAC1 SRC COX5B RNF4 NR2C2 RCHY1 NR2C1 RELA EGFR PSMC3IP NSD1 PLAGL1 NRIP1 FLNA BDNF%IOB%BDNF BDNF IGF2BP1 AKT1 PTK2B MAPK1 SIRPA FYN NCAM1 PLCG1 SH2B2 SH2B1 MAPK3 NTRK1 NGFR NTRK2 CDKL5 BAD KIDINS220 TSC2 FRS2 FRS3 GRIN2B MTOR SYN1 GRIN1 TIAM1 CREB1 RPS6KB1 CAMK4 CTNNB1 RAF1 GABRB3 GRIA1 SHC4 GSK3B PRKAA2 SHC1 IRS1 KCNA3 IRS2 FOXO3 ACACB ELK1 RELB MAPK9 MAPK8 MAPK7 EIF4EBP1 CCR1%IOB%CCR1 CCR1 CCL14 SRC CCL3L3 PXN RELA GNA14 MAPK9 MAPK8 CCL8 CCL7 CCL5 CCL4 CCL3 MAPK1 PTK2B CCL16 MAPK3 JAK1 CCL15 CCR1 CCL23 STAT1 STAT3 PRKCD MAPK14 NFKB1 PTK2 CREB3 ZAP70 CCL26 CCR7%IOB%CCR7 CCR7 MAPK9 MAPK8 RPS6KB1 CFL1 AKT1 MAPK1 PTK2B CCR7 CCL19 PLCG1 JAK2 MAPK3 GSK3B MAP2K4 CCL21 ADRB2 MAPK14 FOXO3 MTOR RELA FOXO1 MAPK10 CCR9%IOB%CCR9 CCR9 MADCAM1 CD226 ITGB7 EZR JAK3 MAPK3 CCL25 GSK3B ITGA4 RDX MSN MAPK14 FOXO1 MAPK8 RPS6KB1 CDH1 CCR9 AKT1 MAPK1 CD40%IOB%CD40 CD40 PIK3R1 IKBKB MAPK9 MAPK8 MYC PLCG2 AKT1 MAPK1 FYN STAT6 JAK3 MAPK3 LYN JUN MAP2K1 SYK CHUK STAT1 STAT3 TRAF2 MAPK14 FGR NFKBIA TRAF3 LCK BIRC3 CXCR4%IOB%CXCR4 CXCR4 VAV2 ZAP70 DOK1 CREB1 LCK RASA1 TFF2 LCP2 RAF1 CRK USP14 SDC4 SRC PXN WAS CXCR4 PIK3R2 PIK3R1 CBL FOXO3 PRKCZ RELA FOXO1 EGFR GNAI1 FYB GNA13 CDC42 SOCS3 PAK1 SOCS1 INPP5D GRK6 STAT4 PLCG2 PTK2B MAPK1 FYN PLCG1 MAPK3 LYN HSPA8 STAT5B VCAM1 BAD STAT1 STAT2 LIMK1 STAT3 PTPN11 PTK2 NFKB1 ESR2 NFKBIA CXCL12 PTPRC RPS6KB1 ACKR3 CTNNB1 PTPN6 BCAR1 NFKBIB ATF1 GSK3B ITK YWHAB ITGB2 CBLB ARRB2 ELK1 CRKL ICAM1 IKBKB RPS6KA3 RPS6KA2 CFL1 PIM1 AKT1 RAC1 JAK2 CCR5 JAK3 JAK1 NCK1 MAP2K3 MAP2K1 MAP2K2 SYK ITGA4 CHUK RPS6 PRKCD TYK2 RHOA VAV1 EGFR1%IOB%EGFR1 EGFR1 ATF1 ITSN2 USP6NL RPL30 TFRC ARAF ATP5C1 HNRNPR ENO1 ELK1 EPS8 ELK4 GJA1 MPRIP TFG UBASH3B MYC AKT1 PLCE1 ANKS1A PRKCG PRKCI PRKCB PRKCD SCRIB FRS2 PRKCA SCAMP3 KIAA1217 ZFYVE16 PRKAR1A SDPR PARD3 MT-CO2 PRKD1 RBCK1 CTBP1 IQGAP1 PRKCZ SLC5A5 LDHA MYO6 PLCG2 PLCG1 S100A14 S100A11 S100A10 LYN JUN AFAP1L2 JUND JUP BRAF CYLD TOLLIP TRIP6 PYGB ARF4 RPLP0 CLTC CLTA SHB ARHGAP5 ENSA PLEKHN1 JAK2 APPL2 JAK1 APPL1 SERPINB3 ANXA1 ANXA2 DUSP1 PGAM1 ANXA4 EPS15L1 FOS DYNLL1 PLSCR1 GPRC5A TKT PHLPP1 AHNAK HTT RPS27L SNX33 EGFR ADRBK1 AP2S1 STX4 FLNB RPS2 LDLR GSN STAT1 STAT2 MCF2 STAT3 HIPK3 HIPK2 DCBLD2 ABI1 PKN2 FRK CTNND1 IRS2 LAPTM4A C11orf52 STK11 CDH3 CYSRT1 GRB14 CDH2 CDH1 CFL1 GRB10 TOM1 MAP3K4 MAGI1 MAP2K3 PIAS3 MAP2K1 MAP2K2 DYRK1A DYRK1B PRPF4B TOM1L1 TOM1L2 HAT1 PKP2 ADAM9 PKP4 PKP3 PHPT1 PHLDB2 COL17A1 KHDRBS1 SHC1 FOXO1 STIP1 SOCS3 ATXN2 SOCS1 HNRNPDL EIF4EBP1 ABL1 ABL2 MAP2K7 SLC38A2 MAP2K5 KIRREL TNK2 GAREM RFXANK NFKB1 PTPRE DAB2 CDK5 PTPRA SP1 CDK2 ALB BCL2 CDK1 MAP3K14 RAB5A EIF4G1 ITGB1 BCAR3 ITGB4 CALCOCO2 PTEN PIK3CD PIK3CB PTPN23 PIK3CG PIK3C2B NCK2 ACP1 CCDC50 NCK1 ACTR3 DSP ACTR2 PDCD6IP PPP1R12A KSR1 ITGA3 SH2D3C ERBB2IP PKM PIK3CA LCK DSG2 SOS1 CRK SOS2 MET SLC25A6 CEBPA PRKAA1 CEBPB PRKAA2 SRC WBP2 HDAC1 ITLN2 SRI CDC42 SLITRK6 FYN CSK RBBP7 HNRNPA1 CTNNAL1 SH2B1 PTPN1 PTPN18 PPP1R14B PTPN11 PTPN12 BAIAP2 MTOR PTPN6 PTPN5 PVRL1 BCAR1 SPG20 ERRFI1 APP AHCYL1 PITPNA ZDHHC5 CBLC CBLB ANTXR1 ACTB CRKL RPS6KA3 BAIAP2L1 RPS6KA5 SNRPD2 TRIM29 RPS6KA2 RPS6KA1 EPHB2 TNS4 TNS3 RPS10 EPHB1 SLC12A7 EPHB4 TNS2 TNS1 EPHB3 EPHA4 ACTN1 KRT8 KRT7 KRT5 ACTN4 TAGLN2 TLN1 RIN1 PFN1 EPHA1 TP53 EPHA2 GRB7 SDC4 STXBP1 SH2D2A SDC3 PIK3R3 PIK3R2 PIK3R1 PTTG1IP MYL12B RACGAP1 RALGDS SNX5 STAT5A VASP STAT5B INSR SIAH2 SIAH1 PTK6 STAM PTK2 SMU1 WNK1 SDC1 CALM3 GRB2 CALM1 CALM2 CC2D1A PTPRR HIP1 SH3KBP1 AP2A1 PTPRK WASL LIMD1 PTPRF OTUD6B RAC1 HRAS GIT1 VAV3 CDV3 MINK1 GAB1 TYK2 GAB2 IL17RD VAV1 RHOA VAV2 CEACAM1 CTTN KIT ARHGEF4 ALDOA ARHGEF7 ARHGEF5 CSTB NEDD9 PRKX RELA PAK1 SH3BGRL PDZD11 CD59 MAP4K5 EPS15 MPZL1 MAP3K2 MAP3K3 GIT2 MAP3K1 HUWE1 PLEKHA5 PLEKHA6 AP2B1 ITCH KRT18 KRT17 AXL NEDD4 EPPK1 ESYT1 TJP2 SH3GL3 NDUFA13 INPPL1 PEBP1 ARHGAP35 SIRPA PTRF SH3GL2 KRT6A PDGFRB RALBP1 APLP2 EEF1A1 DOK1 DOK2 ADAM17 HGS EEF1A2 ELMO2 RAF1 STAM2 VCL DDX6 PXN DAPP1 PLD1 LPP PLD2 EFNB2 SDCBP UBB CALD1 CASKIN2 RIPK1 SMAD2 SMAD3 CAV2 CAV1 CRIM1 ARHGAP32 DLG3 GSK3B DYRK4 DYRK3 GSK3A DOCK4 DDX3X USP31 YWHAB RBM3 CASP9 FLOT1 FLOT2 TGIF1 KLF11 PDPK1 LSR ARAP1 YWHAZ EPN1 DNM1 EPN2 EPN3 ACTA2 SFPQ CREB1 ELF3 PEAK1 RASA1 MYH9 DOCK1 PLEC RALB MVP RGS16 CAMK2A ASAP3 ASAP1 ATP1A1 CBL PDLIM1 MAPK9 MAPK8 MAPK7 MARVELD2 ERBB3 ERBB2 REPS2 MAPK1 PTK2B MTA2 PDLIM4 MAPK3 REPS1 SNCA BAD NOS3 EGF SPRY4 PPP2R3A MAPK14 HSPE1 TNIP1 RPS6KB1 HIST3H3 SPRY3 SPRY2 SPRY1 VIM ZPR1 EPO%IOB%EPO EPO GSK3B GSK3A IRS2 CRKL RPS6KA5 AKT1 JAK2 MAP4K1 MAP2K1 MAP2K2 SYK DAPK2 GAB1 GAB2 VAV1 HIST2H2BE HCLS1 RAF1 SGK1 SHC1 GATA4 PIK3R2 PIK3R1 MST1R FOXO4 CBL FOXO3 GATA1 FOXO1 MAPK9 MAPK8 BCL2L11 INPP5D PLCG2 MAPK1 PLCG1 SH2B2 PAG1 MAPK3 LYN STAT5A STAT5B JUN NOS3 STAT1 BAD STAT3 PTPN11 BRAF EPOR MTOR NFKBIA FAS%IOB%FAS Fas PDCD6 PARK2 IGF1R TIAL1 ARHGDIB CDC27 AKT1 MAP3K5 CAST DAXX MAP2K1 MAP2K2 CSNK2A1 PRKCD UBE4B CSNK1E PSME3 CSNK2B BTK EZR RAF1 UBA7 DIABLO PRKDC MAX STK4 DEDD2 STK3 RIPK1 FADD LYN TIA1 UBE2I INSR EIF2AK2 BMX EIF2S1 STK24 BCL2 BCL2L1 GSK3B NUMA1 FAF1 HSPB1 FASLG LMNB1 CASP9 CASP7 CASP8 AIFM1 CASP10 CASP6 FASTK CASP3 CASP4 XPO5 CASP1 CASP2 RAC1 SPTAN1 DFFA RFC1 PARP1 RIPK2 ANXA4 MST1 TRAF2 TRAF1 LCK TRAF3 RASA1 TCP1 TOP1 MET PLEC GTF3C3 PARG ROCK1 SATB1 SRF USO1 XIAP GLRX EGFR RELA CDC42 MAPK9 MAPK8 SRP72 MAPK1 CD59 FYN BID PAK2 DEDD EIF4B MAPK3 CASP8AP2 MBD4 MAP3K1 GSN CSNK1A1 CFLAR MAPK14 CDK11B HIPK3 WEE1 NEDD4 EIF3J FAS BAX PTPN6 PKN2 VIM PKN1 FLK2 FLT3%IOB%FLK2 FLT3 FLK2 FLT3 SHC1 STAT3 GAB1 PTPN11 CBLB GAB2 CBL FOXO3 CREB1 INPP5D AKT1 MAPK1 JAK2 MAPK3 LYN STAT5A ATF1 ATF2 CEBPA STAT5B JUN BAD FLT3 G-CSF%IOB%G-CSF G-CSF MAPK3 JAK1 LYN STAT5A STAT5B PRKCI SYK CISH BAD NOS3 STAT1 STAT3 PTPN11 TYK2 GAB2 SYP CSNK1E MAPK14 VAV1 SOD1 HCK TEC LCK CDK2 IL3RA REL GRB2 NOTCH2 GSK3B CSF3 GSK3A POM121 NOTCH1 CSF3R CDKN1B SHC1 PLA2G1B CBL SOCS3 FTH1 INPP5D RPS6KA1 AKT1 MAPK1 JAK2 GDNF%IOB%GDNF GDNF TH DOK4 RPS6KB1 DOK5 DOK6 CDK1 RAF1 MET CRK BCAR1 ATF1 RET SRC SHC1 PXN CBLB PIK3R1 CBL RPS6KA3 MAPK7 MAPK1 AKT1 PTK2B FYN PLCG1 MAPK3 JUN MAP2K1 MAP2K2 GAB1 GAB2 CDC25C PTK2 NFKBIA DOK1 DOK2 CREB1 GM-CSF%IOB%GM-CSF GM-CSF CSF2RA PRDX3 MAPK9 GANAB MAPK8 MAPK7 MAPK1 PLCG1 SH2B2 CCT5 MAPK3 MAP2K6 STAT5A LYN STAT5B TGFB1 YES1 BAD STAT1 STAT3 PTPN11 STAM MAPK14 GNB2L1 NFKB2 NFKBIA TEC PTPRC RPS6KB1 FES BCL3 PTPN6 GRB2 BCAR1 MAD2L1 GSK3B GSK3A CSF2 SLC2A1 IRS2 PARK7 ELK1 CRKL IKBKB CASP8 RPS6KA2 DPYSL2 AKT1 JAK2 EPHB2 JAK3 SPTAN1 JAK1 PDIA3 MAP2K3 MAP2K1 MAP2K2 SYK PARP1 CHUK GAB1 PLA2G4A PRKCA YWHAZ VAV1 TGFBR3 HCK CREB1 HNRNPH1 KIT RAF1 PFN1 EZR STAM2 SHC1 PXN CSF2RB PIK3R2 PIK3R1 FOXO3 CBL HEDGEHOG%IOB%HEDGEHOG Hedgehog SMAD1 CREBBP PTCH1 PTCH2 DYRK1A KIF7 MED6 KIF27 SKI MED23 CDK8 SMO CTNNB1 GAS1 YWHAE DHH SDC2 HHIP IHH ARRB2 NR2E1 GLI1 GLI3 GLI2 MED12 CCNB1 SHH HHAT STK36 SIN3A ADRBK1 RAB23 SUFU BOC SAP18 AKT1 PRKACA CDON MED1 ID%IOB%ID ID RB1 ELK1 ELK3 ELK4 IFI16 PSMD4 HES1 MYOG TCF7L2 SREBF1 SMAD3 TCF12 PAX5 PAX2 RBL2 RBL1 PAX8 ID2 MYOD1 ID1 CDK2 ID4 MYF6 ID3 TCF3 ATF3 MYF5 IFN-ALPHA%IOB%IFN-ALPHA IFN-alpha MTOR VAV1 TNFRSF10D NFKBIA ZAP70 ARHGAP30 RPS6KB1 PRKCQ CRK IFNAR1 IRS1 IRS2 CBL FOXO1 CRKL RPS6KA5 ERBB3 STAT4 EIF4EBP1 AKT1 STAT6 EIF4B JAK1 MAP2K6 MAP2K3 IFNAR2 STAT5A STAT5B MAP2K4 STAT1 STAT2 PRKCD STAT3 RPS6 PLA2G4A TYK2 MAPK14 IFN-GAMMA%IOB%IFN-GAMMA IFN-gamma IFNGR1 PRKCE STAT2 RPS6 PRKCD STAT3 PLA2G4A MAPK14 VAV1 MAPK11 CREB1 IRF1 IRF2 IRF8 PRKCQ RAF1 CRK MAP3K11 GSK3B CEBPB SPI1 SRC CBL EGFR CRKL HOXA10 MAPK8 PLCG2 AKT1 MAPK1 PTK2B STAT6 PRKACA JAK2 EIF4B MAPK3 JAK1 STAT5A STAT5B JUN STAT1 KITRECEPTOR%IOB%KITRECEPTOR KitReceptor SOS1 RAF1 CRK GRB7 SHC1 SRC WAS PIK3R2 CSF2RB PIK3R1 CBL RELA PAK1 MAPK8 SOCS1 INPP5D EIF4EBP1 ABL1 MAPK1 STAP1 FYN PLCG1 SOCS6 MPDZ SH2B3 SOCS4 SH2B2 MAPK3 SOCS5 LYN STAT5A STAT5B JUN YES1 BAD STAT1 STAT3 NFATC2 PTPN11 TNFRSF10A MAPK14 EPOR MTOR KITLG FER TEC RPS6KB1 FES GRB2 PTPN6 GRAP IL7R LAT MAD2L1 PTPRU GSK3B ATF2 GSK3A WIPF1 SH3KBP1 CLTC CBLB ELK1 CRKL GYS1 SPRED2 SPRED1 RPS6KA1 GRB10 EP300 AKT1 JAK2 JAK3 HRAS ACTR2 MAP2K1 MAP2K2 PRKCB RPS6 MATK PRKCA MITF GAB2 VAV1 FGR HCK DOK1 PIK3CA RASA1 KIT BTK LEPTIN%IOB%LEPTIN Leptin ATF2 GSK3B GSK3A ITGB5 IRS1 PTEN HSPB1 IRS2 SLC2A4 ELK1 CFL2 RPS6KA2 LEPR AKT1 ITGAV JAK2 JAK3 MAP2K3 PDIA3 MAP2K1 MAP2K2 PRKCE NCOA3 RPS6 PRKCD MAPKAPK2 RAF1 KHDRBS1 PIK3R2 PIK3R1 PRKCZ EGFR MAPK1 SOCS7 MAPK3 MAP2K6 SH2B1 STAT5B STAT1 STAT3 PTPN11 MAPK14 PTK2 NFKB1 TH RPS6KB1 SP1 LEP PDE3A GRB2 M-CSF%IOB%M-CSF M-CSF CSF1 ITGB3 INPPL1 SLA2 ETS2 CASP8 PSTPIP2 GRAP2 MYO18A AKT1 ITGAV JAK1 MAP2K1 MAP2K2 PRKCE TFE3 RPS6 PRKCD GAB3 MITF GAB2 TYK2 THOC5 DNM1 RASA1 RAF1 SOS1 SKAP2 LILRA6 KHDRBS1 CSF1R SHC1 SRC PXN PIK3R1 CBL PPP2CA INPP5D PLCG2 EIF4EBP1 MAPK1 PTK2B RIPK1 PLCG1 FADD PAK2 MAPK3 LYN STAT5A STAT5B STAT1 STAT3 PTPN11 LILRB3 PTK2 RPS6KB1 RPS6KB2 PTPN6 GRB2 VIM PTPN2 BCAR1 NGF%IOB%NGF NGF CREB1 IRAK1 SP1 DNAJA3 NCL RPS6KA1 MAPK1 PLCG1 SH2B1 MAPK3 NTRK1 MAP2K1 PRKCI MAP2K2 SHC1 BAD GAB1 BRAF PTPN11 FRS2 ELK1 NOTCH%IOB%NOTCH Notch PSEN1 ASCL1 DLL1 RELA DLL3 APH1A DLL4 NCSTN APH1B BLOC1S1 MAPK1 HES1 HIVEP3 HES5 MAPK3 JAG2 SPEN SMAD1 SMAD4 JAG1 SMAD3 STAT3 WDR12 NFKB1 ITCH SNW1 CNTN1 TCF3 GSK3B APP MAML2 MAML1 FHL1 RBPJ YY1 LFNG HEY1 SIN3A POFUT1 HEY2 MAGEA1 EP300 CIR1 SKP2 JAK2 SKP1 PSENEN HES6 MEF2C TLE1 RING1 FBXW7 ADAM10 RBX1 SAP30 NCOR2 KAT2B ADAM17 NCOR1 NOV LCK MFNG NUMB MAML3 NOTCH2 NOTCH3 NUMBL HDAC2 NOTCH1 HDAC1 NOTCH4 LEF1 PSEN2 CUL1 DTX1 FURIN PIK3R2 PIK3R1 TGF_BETA_RECEPTOR%IOB%TGF_BETA_RECEPTOR TGF_beta_Receptor NEDD4L PIK3R2 FOXO4 PIK3R1 FOXO3 ANAPC10 FOXO1 CCNB2 SNX4 SNX1 SNX2 PRKAR2A DVL1 SKIL SPTBN1 MAP2K6 SNX6 SMAD2 TRAP1 WWTR1 HSPA8 CREBBP JUN SMAD4 TGFB2 JUND SMAD3 TGFB1 SMURF2 STK11IP VDR SMURF1 TGFB3 CAV1 IRF2BP1 NUP153 SMAD6 ESR1 PTK2 SMAD7 DAB2 CDK6 SNW1 COPS5 CDK4 SP1 GIPC1 CDK2 CDC16 CDK1 GRB2 DYNLRB2 DYNLRB1 TAB1 DCP1A TP73 ACVRL1 CDKN1A CITED1 BRCA1 CTCF ARRB2 MED15 ING2 XPO1 XPO4 SUMO1 HNF4A MAP4K1 NCOA1 TGIF1 AXIN1 AXIN2 FOS UCHL5 RHOA TGFBR1 TGFBR2 NME1 PJA1 ERBB2IP RBL2 TGFBR3 PPM1A KAT2B ZEB2 TFDP1 RBL1 ZEB1 TFDP2 STRAP SOS1 CRK CD44 ENG CAMK2B YAP1 CAMK2D ROCK1 HDAC1 LEF1 CAMK2A PPP2CA MAPK8 FZR1 PARD6A STAMBPL1 MAPK1 E2F4 E2F5 CAMK2G DYNC1I1 MAPK3 NFYA NFYB NFYC AP2B1 MAPK14 PML FKBP1A SKI ITCH EIF3I CTNNB1 FOSB BCAR1 RB1 ATF2 SPARC ZFYVE9 UBE2D2 UBE2D3 UBE2D1 PPP2R2A ETS1 HOXA9 STK11 CDC23 FNTA CCND1 MYC CDC27 EP300 AKT1 SNIP1 SOX9 BTRC JUNB MAP3K7 RNF111 VPS39 PDK1 SKP1 MAP2K3 PRKCG NUP214 MEF2A MEF2C DAXX ANAPC7 PRKCB FOXH1 PRKCD RUNX2 CDC25A PIAS2 RBX1 PIAS1 AR EID2 ZFYVE16 PRKAR1B CCNE1 HGS EWSR1 PARD3 ANAPC4 ANAPC5 RAF1 TP53 ATF3 ANAPC1 CSNK1G2 KPNB1 ANAPC2 DDX5 SHC1 SDC2 FOXG1 PXN CUL1 THROMBOPOIETIN%IOB%THROMBOPOIETIN Thrombopoietin GAB1 MPL MAPK1 JAK2 FOXO3 MAPK3 ATXN2L STAT5B MAP2K1 SHC1 STAT3 TIE1 TEK%IOB%TIE1 TEK TIE1 TEK BMX MAPK14 ELK1 FOXO1 PTK2 PAK1 DOK2 FES AKT1 MAPK1 TEK RAF1 MAPK3 NCK1 STAT5A STAT5B GRB7 MAP2K1 MAP2K2 SHC1 NOS3 TIE1 PXN TNFALPHA%IOB%TNFALPHA TNFalpha RPL4 RB1 RPL30 SMARCB1 MLC1 RPL8 DCAF7 RPL6 MYLK PSMD6 RPS6KA5 PSMD7 TBK1 PSMD2 AKT2 PSMD3 DPF2 AKT1 PSMD1 BTRC RPS11 RPS13 SKP1 SMARCC1 SMARCC2 CSNK2A1 PRKCD CDC34 KCNQ1 CDC37 TRIB3 TP53 IQGAP2 PRKCZ GLG1 FADD STAT5A CREBBP JUN CRADD PTK2 SMARCA4 REL FAF1 IKBKAP IKBKB CASP10 NKIRAS1 NKIRAS2 IKBKG IKBKE SYK RIPK3 ACTL6A GAB1 COMMD1 AKAP8 TANK RELA EGFR RELB PSMB5 FLNA BID MAP3K2 MAP3K3 MAP3K1 STAT1 LRPPRC KTN1 PSMC3 PSMC1 PSMC2 PKN1 HSPA1A CCNT1 UBE2D2 ZFAND5 UBE2D3 TNF FBL KPNA6 PAPOLA TNFRSF8 MAP3K8 AZI2 KPNA2 MAP3K7 KPNA3 GTF2I PIAS3 MAP2K1 UNC5CL FBXW7 FBXW11 USP2 TRPC4AP DOK1 TXLNA FANCD2 MAPKAPK2 NUPR1 FKBP5 NSMAF COPB2 PSMD12 PSMD13 CUL1 RASAL2 TNFRSF11A BAG4 BRINP1 NLRP4 G3BP2 RIPK1 MAP2K5 MARK2 MAP2K6 HSPA8 UBE2I HSPA5 SEC16A CAV1 TRAPPC9 MCC GNB2L1 NFKB1 NFKB2 NFKBIA CDK9 COPS3 IRAK1BP1 COPS5 BCL3 TAB3 ALPL TAB2 TAB1 NFKBIE MAP3K14 MAP3K11 NFKBIB YWHAE DDX3X HSP90AB1 MCM7 YWHAB TRADD TNFAIP3 HSPB1 HMGB1 PPP6C CASP7 CASP8 SUMO1 YWHAQ BCL7A PPP1R13L CASP3 NFKBIZ CASP2 YWHAG YWHAH HSP90AA1 PEG3 CHUK TRAF2 TRAF1 TNFRSF1B YWHAZ TNFRSF1A TRAF7 CREB1 TRAF4 RASA3 POLR1A TRAF3 TRAF6 POLR1B POLR1C TRAF5 POLR1D POLR1E PFDN2 MCM5 BIRC2 HDAC2 SRC HDAC1 USP11 MTIF2 NR2C2 HDAC6 MAPK9 MAPK8 TIFA MAPK1 POLR2H MAPK3 POLR2L SMARCE1 SPAG9 RNF25 PTPN11 CFLAR MAPK14 PML RPS6KB1 PRC1 TNIP2 GLB1 HIST3H3 BAX TBKBP1 PDCD2 TNFSF1%IOB%TNFSF1 TNFSF1 LTBR LTB JUN TNFRSF19 TNFRSF1B RELA NFKB1 RELB NFKB2 TNFRSF1A NFKBIA TRAF3 TRAF5 LTA AKT1 TNFRSF14 IKBKG TNFSF3%IOB%TNFSF3 TNFSF3 JUN TRAF2 TNFRSF1B RELA NFKB1 RELB NFKB2 TNFRSF1A NFKBIA TRAF3 TRAF5 LTA LTBR LTB TNFSF8%IOB%TNFSF8 TNFSF8 TRAF5 REL TNFRSF8 AKT1 MAPK1 TNFSF8 MAP3K14 NFKBIB CHUK TRAF2 TRAF1 MAPK14 RELA NFKB1 RELB NFKB2 IKBKB NFKBIA TRAF3 BCL3 TRAIL%IOB%TRAIL TRAIL TRADD CASP7 CASP8 AIFM1 CASP10 CHEK2 CASP3 CASP1 TNFSF10 AKT1 CASP2 IKBKG MAP3K7 CTSB APAF1 CSNK2A1 PARP1 H2AFX TRAF2 CREB1 NGFRAP1 VDAC1 IRF5 DAP3 PRKAA1 DIABLO SRC PRKDC XIAP TNFRSF11B BCL10 CBL RELA MAPK9 MAPK8 MAPK1 RIPK1 BAK1 FADD BID MAPK3 MCL1 JUN TNFRSF10C TNFRSF10B TNFRSF10A CFLAR MAPK14 NFKB1 TNFRSF10D NFKBIA CTNNB1 BAX CYCS ATM WNT%IOB%WNT Wnt DIXDC1 FZD10 FRAT1 FRAT2 SOX1 CCND1 CDH2 CDH1 AKT1 BTRC PRKACA MAP3K7 MAP3K4 PRKCG MAP2K4 PRKCH WNT5B PRKCB PRKCE WNT5A PRKCD PRKCA CSNK1D CSNK1E DKK1 SFRP4 SFRP1 SFRP2 DAAM1 PRKCQ ROR1 ROR2 RAF1 PI4K2A CTBP2 CTBP1 CHRNA7 NLK WNT6 DVL1 DVL2 DVL3 PIP5K1B WNT1 WNT2 WNT3 MARK2 WNT4 FZD1 SMAD1 KL FZD3 JUN GCKR YES1 FZD2 JUP SETDB1 FZD5 WNT3A FZD4 FZD7 FZD6 FZD9 FZD8 NFATC2 BCL9 DAB2 CDK6 PPP1R1B PIN1 TCF4 TCF3 GSK3B GSK3A YWHAB CHD7 ILK ARRB1 ARRB2 RSPO2 RSPO3 RSPO1 RAC1 MESDC2 AXIN1 WNT9B KREMEN1 AXIN2 WNT9A RHOA PAX2 ARHGEF4 PPARG LRP1 SRC LEF1 LRP5 LRP6 PPP2CA MAPK8 WNT11 WIF1 FRZB GPC3 MAPK1 MAPK3 TCF7L2 MAP3K1 CSNK1A1 RYK WNT7B WNT7A PPP1CA APC RPS6KB2 CTNNB1 PID_IL2_PI3K_PATHWAY%MSIGDB_C2%PID_IL2_PI3K_PATHWAY PID_IL2_PI3K_PATHWAY PTPN11 GAB2 NFKB1 MTOR IL2 RPS6KB1 PIK3CA LCK IL2RA IL2RB BCL2 GRB2 SOS1 EIF3A BCL2L1 SGMS1 SHC1 PIK3R1 IL2RG FOXO3 PRKCZ RELA UGCG TERT SMPD1 MYC MYB E2F1 AKT1 RAC1 JAK3 JAK1 HSP90AA1 RPS6 NABA_BASEMENT_MEMBRANES%MSIGDB_C2%NABA_BASEMENT_MEMBRANES NABA_BASEMENT_MEMBRANES LAMC2 LAMC1 NID1 NID2 NTN1 NTN3 HMCN1 NTNG1 NTNG2 LAMB3 LAMB2 LAMB4 LAMB1 NPNT HSPG2 USH2A COLQ COL4A2 COL4A1 COL4A4 COL6A2 COL6A1 COL4A3 COL4A6 COL6A3 COL4A5 COL6A6 COL6A5 AGRN COL18A1 LAMA5 COL15A1 LAMA2 LAMC3 LAMA1 LAMA4 LAMA3 PAPLN NTN4 NTN5 PID_E2F_PATHWAY%MSIGDB_C2%PID_E2F_PATHWAY PID_E2F_PATHWAY RB1 CDKN1A CDKN1B TRRAP SERPINE1 BRCA1 UXT YY1 CCND3 CASP7 TRIM28 PLAU EP300 MYBL2 TK1 TOPBP1 SULT2A1 PRMT5 APAF1 TFE3 SIRT1 CES4A CDC25A HIC1 RBL2 CCNA2 KAT2B KAT2A RBL1 TFDP1 CCNE2 TFDP2 CCNE1 MCM3 CES3 CES2 CES1 CEBPA HDAC1 CES1P1 TYMS CES5A ORC1 RBBP4 RBBP8 E2F2 E2F3 E2F4 E2F5 WASF1 E2F6 E2F7 MCL1 RANBP1 CREBBP RRM1 RRM2 CDKN2C CBX5 CDKN2A XRCC1 CDC6 SMARCA2 DHFR POLA1 RYBP SP1 CDK2 CDK1 ATM HBP1 TP73 MYC E2F1 PID_P53_DOWNSTREAM_PATHWAY%MSIGDB_C2%PID_P53_DOWNSTREAM_PATHWAY PID_P53_DOWNSTREAM_PATHWAY BCL2 BCL2L1 FOXA1 CCNK STEAP3 CD82 CSE1L PRDM1 PYCARD SESN1 FDXR TP63 BNIP3L S100A2 HGF IGFBP3 TAP1 TSC2 PRKAB1 DKK1 MSH2 DDIT4 TP53 ATF3 EPHA2 DDX5 TGFA AK6 NDRG1 CCNB1 PCBP4 TP53BP2 PMAIP1 SFN SCN3B COL18A1 BCL2L14 PLK3 JUN GADD45A VDR CAV1 SH2D1A TNFRSF10C LIF TNFRSF10B TNFRSF10A SMARCA4 TNFRSF10D TADA2B TP53I3 RGCC BCL6 JMY MDM2 SNAI2 BCL2L2 BTG2 PPP1R13B PTEN TRIAP1 CX3CL1 BBC3 PIDD1 CASP6 CASP10 AIFM2 BDKRB2 CASP1 DGCR8 CTSD ZNF385A DUSP5 EDN2 GPX1 DUSP1 PRMT1 MMP2 SERPINB5 DDB2 RNF144B VCAN RRM2B IRF5 MET HDAC2 PCNA BCL2A1 TYRP1 RPS27L HTT PPM1J NLRC4 AFP RCHY1 EGFR PERP TP53INP1 SPP1 PMS2 DROSHA BAK1 BID MAP4K4 TIGAR NFYA GDF15 NFYB NFYC ARID3A MLH1 POU4F1 POU4F2 PML APC RB1 RFWD2 CDKN1A CARM1 CCNG1 TRRAP BAX SERPINE1 FAS CEBPZ EP300 APAF1 HIC1 KAT2A TFDP1 E2F2 E2F3 MCL1 CREBBP SP1 TP73 E2F1 PID_FANCONI_PATHWAY%MSIGDB_C2%PID_FANCONI_PATHWAY PID_FANCONI_PATHWAY BLM WDR48 FAAP24 BRCA2 BRIP1 CHEK1 USP1 BRCA1 HES1 ATM NBN ATRIP FAAP100 FANCI RFC5 RFC3 RFC4 FANCM FANCL TOPBP1 RMI1 FBXW11 RFC2 XRCC3 TOP3A H2AFX FANCA RPA1 MRE11A RPA2 HUS1 FANCC FANCB FANCE PALB2 FANCG FANCF RAD50 APITD1 FANCD2 UBE2T SSPO RAD17 RAD1 FAN1 ATR RAD9A BIOCARTA_MEF2D_PATHWAY%MSIGDB_C2%BIOCARTA_MEF2D_PATHWAY BIOCARTA_MEF2D_PATHWAY PPP3CA PPP3CB PPP3CC CAPNS1 CAPNS2 CAPN2 CALM3 HDAC2 CALM1 CALM2 MEF2D HDAC1 EP300 PRKCB NFATC2 PRKCA NFATC1 CABIN1 PID_TGFBR_PATHWAY%MSIGDB_C2%PID_TGFBR_PATHWAY PID_TGFBR_PATHWAY DAXX PDPK1 AXIN1 RHOA PML TGFBR1 TGFBR2 RPS6KB1 TGFBR3 ZFYVE16 STRAP YAP1 PPP1R15A CAMK2A GRB2 SOS1 TGFBRAP1 XIAP NEDD4L PPP2CA PPP2CB PARD6A SKIL SPTBN1 SMAD2 TGFB2 SMAD4 TGFB1 SMAD3 SMURF2 SMURF1 TGFB3 WWP1 PPP1CA SMAD7 FKBP1A ITCH OCLN DAB2 BAMBI CTNNB1 TAB2 TAB1 DYNLRB1 CAV1 SHC1 YWHAE ZFYVE9 PPP2R2A ARRB2 CTGF DACT2 MAP3K7 RNF111 EIF2A PID_SYNDECAN_4_PATHWAY%MSIGDB_C2%PID_SYNDECAN_4_PATHWAY PID_SYNDECAN_4_PATHWAY RHOA ITGB1 SDC4 TNFRSF13B TNC CXCR4 PRKCA PLG TFPI THBS1 FGF2 FGF6 SDCBP MDK CCL5 ACTN1 FZD7 PRKCD FN1 F2 NUDT16L1 MMP9 PTK2 DNM2 CXCL12 GIPC1 ADAM12 ITGA5 FGFR1 LAMA1 RAC1 LAMA3 PID_LPA4_PATHWAY%MSIGDB_C2%PID_LPA4_PATHWAY PID_LPA4_PATHWAY PRKCE ADCY4 ADCY3 ADCY2 LPAR4 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 ADCY9 GNAL RPS6KA5 CREB1 PRKACA PID_NECTIN_PATHWAY%MSIGDB_C2%PID_NECTIN_PATHWAY PID_NECTIN_PATHWAY RAPGEF1 TLN1 PVRL3 CRK PVRL2 PVRL1 PIK3CA CTNNB1 SRC PTK2 ITGB3 PDGFB PIK3R1 PTPRM IQGAP1 F11R MLLT4 CLDN1 PVR CDC42 RAP1B RAP1A CDH1 CTNNA1 ITGAV RAC1 PIP5K1C FARP2 PDGFRB VAV2 PID_AURORA_B_PATHWAY%MSIGDB_C2%PID_AURORA_B_PATHWAY PID_AURORA_B_PATHWAY KIF2C TACC1 VIM RHOA KIF20A CUL3 CDCA8 NCAPG PEBP1 KLHL13 AURKC SMC4 CENPA NCAPH AURKB MYLK AURKA SMC2 PPP1CC SGOL1 RACGAP1 STMN1 BUB1 EVI5 NPM1 NSUN2 SEPT1 KIF23 PPP2R5D NDC80 KLHL9 PSMA3 DES INCENP RASA1 NCL BIRC5 CBX5 NCAPD2 PID_ARF6_TRAFFICKING_PATHWAY%MSIGDB_C2%PID_ARF6_TRAFFICKING_PATHWAY PID_ARF6_TRAFFICKING_PATHWAY IL2RA CTNNB1 CTNND1 CLTC SLC2A4 EDNRB ITGA4 ITGA3 EXOC7 ITGA2 ITGA1 AVPR2 MAPK8IP3 SCAMP2 NME1 ACAP1 CDH1 BIN1 ITGA8 CTNNA1 ITGAV EXOC4 AGTR1 PIP5K1C ITGA7 EXOC3 ITGA6 EXOC6 EXOC5 EXOC2 ITGA9 EXOC1 VAMP3 ARF6 RALA ADRB2 ASAP2 PLD1 KLC1 PLD2 INS SPAG9 TSHR ITGA10 ITGA11 CPE ITGB1 DNM2 ITGA5 BIOCARTA_TGFB_PATHWAY%MSIGDB_C2%BIOCARTA_TGFB_PATHWAY BIOCARTA_TGFB_PATHWAY TGFBR1 APC TGFBR2 TAB1 EP300 SKIL SMAD2 TGFB2 SMAD4 TGFB1 SMAD3 ZFYVE9 CDH1 MAP2K1 CREBBP TGFB3 MAPK3 MAP3K7 SMAD7 PID_A6B1_A6B4_INTEGRIN_PATHWAY%MSIGDB_C2%PID_A6B1_A6B4_INTEGRIN_PATHWAY PID_A6B1_A6B4_INTEGRIN_PATHWAY ITGB4 LAMC2 YWHAB LAMC1 MST1R RXRB RXRA YWHAQ RPS6KB1 ERBB3 PIK3CA ERBB2 RXRG HRAS LAMB3 YWHAG LAMB2 YWHAH GRB2 EGF LAMB1 MST1 CASP7 YWHAZ IL1A PMP22 CD9 ITGB1 PRKCA MET SHC1 PIK3R1 EGFR SFN LAMA5 YWHAE LAMA2 LAMC3 CDH1 LAMA1 AKT1 LAMA4 RAC1 LAMA3 COL17A1 ITGA6 PID_EPHB_FWD_PATHWAY%MSIGDB_C2%PID_EPHB_FWD_PATHWAY PID_EPHB_FWD_PATHWAY CRK PIK3CA HRAS GRB2 GRIA1 GRB7 ROCK1 PXN ITSN1 WASL EFNA5 SRC KALRN PTK2 SHC1 EFNB2 PIK3R1 EFNB1 PAK1 NRAS EFNB3 RRAS MAPK1 EPHB2 CDC42 EPHB1 RAP1B EPHB4 RAP1A EPHB3 MAP4K4 NCK1 DNM1 RAC1 MAP2K1 TF MAPK3 SYNJ1 RASA1 KRAS PID_MYC_PATHWAY%MSIGDB_C2%PID_MYC_PATHWAY PID_MYC_PATHWAY CDKN2A AXIN1 PML TRRAP HBP1 PPP2CA GSK3B MAX KAT5 RUVBL2 RUVBL1 SKP2 PAK2 ZBTB17 TAF12 FBXW7 TAF10 KAT2A ACTL6A PPP2R5A SUPT7L SUPT3H PIN1 AK6 MYC BIOCARTA_PLCE_PATHWAY%MSIGDB_C2%BIOCARTA_PLCE_PATHWAY BIOCARTA_PLCE_PATHWAY ADCY1 RAP2B PRKAR1B PRKAR2B ADRB2 PTGER1 PRKAR1A PRKACG PRKAR2A GNAS PLCE1 PRKACB ST_JAK_STAT_PATHWAY%MSIGDB_C2%ST_JAK_STAT_PATHWAY ST_JAK_STAT_PATHWAY SOAT1 REG1A JAK2 PIAS1 JAK3 PTPRU JAK1 PIAS3 CISH NABA_MATRISOME_ASSOCIATED%MSIGDB_C2%NABA_MATRISOME_ASSOCIATED NABA_MATRISOME_ASSOCIATED C1QTNF5 TIMP2 ANXA6 ANXA7 TIMP3 ANXA8 ANXA9 TIMP1 FGFBP3 TIMP4 PF4V1 SERPINB3 SERPINB4 SERPINB1 FGFBP1 LEFTY1 ANXA1 FGFBP2 SERPINB2 ANXA2 ANXA3 ANXA4 ANXA5 WNT9B SERPINB9 WNT9A SERPINB7 PRSS12 SERPINB8 MMP10 SERPINB6 MMP12 F7 S100A2 MMP11 HGF MMP14 MMP13 F9 MMP16 ANGPTL7 MMP15 ANGPTL6 MMP17 ANGPTL3 MMP19 ANGPTL2 ANGPTL5 TGFA ANGPTL4 ANGPTL1 HBEGF SERPINB10 CCL14 SERPINB11 CCL13 SERPINB12 FIGF SERPINB13 CCL11 CTF1 SERPINC1 ADAM22 WNT8A ADAM21 WNT8B LIF ADAM20 FSTL1 FSTL3 NTF4 ADAM29 LMAN1 ADAM28 CST11 FRZB ADAM23 NTF3 CCL19 CCL18 P4HTM LEFTY2 CCL17 CCL16 CX3CL1 CCL15 CCL25 EGLN1 CCL24 CCL23 EGLN3 CCL22 EGLN2 F10 CTSD SERPIND1 CCL21 CCL20 WNT7B F12 ADAM33 BMP8A MMP2 SERPINB5 ADAM32 WNT7A BMP8B ADAM30 SULF1 PLXDC2 PLXDC1 AGT SULF2 CLCF1 CLC CRLF3 INHA CCL28 CCL27 CRLF1 PF4 CCL26 SEMA5A SEMA5B CSF3 CSF2 CLEC4M PLXND1 CSF1 EPO REG1B PLOD3 F13A1 GDF15 PLOD2 PLOD1 CXCL13 FGF1 TNF CXCL14 FGF3 FGF4 FGF5 FGF7 FGF8 FGF9 CLEC5A PLXNC1 RPTN SEMA6B SEMA6C IFNA13 SEMA6A IFNA14 S100A1 IFNA16 SEMA6D FST IFNA17 PGF ADAM2 CLEC4A CLEC4C CLEC4D S100A6 ADAM9 S100A5 ADAM8 S100A4 ADAM7 S100A3 CLEC4E CLEC4F S100A9 CLEC4G S100A8 S100A7 IFNA10 REG3A SEMA7A PARM1 CSH2 CSH1 CHRD REG3G KNG1 TPO CLEC7A CPAMD8 PLXNA2 PLXNA1 PI3 PLXNA4 PLXNA3 IFNA21 AMBP BDNF KY IFNW1 TMPRSS15 CXCL10 CXCL11 INS-IGF2 P4HA1 P4HA2 P4HA3 CLEC6A PLXNB3 CSPG5 PLXNB2 PLXNB1 CSPG4 HPSE BMP10 FASLG ELFN2 ELFN1 TNFSF13B BMP15 ADAMTS4 S100A7A ADAMTS5 INSL6 ADAMTS2 ADAMTS3 CLEC1A ADAMTS1 ADAMTS8 CLEC1B INSL3 AMH ADAMTS9 ADAMTS6 CSTL1 HGFAC INSL5 ADAMTS7 MBL2 OVGP1 CFC1B ZFP91 NRG1 NRG2 C1QL4 NGF C1QL3 C1QL2 MUC5AC ADAMTS20 C1QL1 NRG3 MEP1B MEP1A NRG4 XCL2 XCL1 CERS1 ITIH5 ITIH4 ITIH3 ITIH2 SFTPA2 SEMA3C CLEC2L SEMA3D SEMA3A ITIH6 SEMA3B ITLN1 SEMA3G ITLN2 SEMA3E SEMA3F ITIH1 CLEC3A CLEC3B CCL8 CCL7 CCL4 CCL3 CCL2 CCL1 ANGPT4 SEMA4A ANGPT2 ANGPT1 SEMA4D SEMA4B SEMA4C SEMA4F SEMA4G CLEC2A CLEC2B LEP TLL2 TLL1 SFTPA1 CBLN4 CLEC2D CBLN3 CBLN2 CBLN1 IL1RN HPSE2 HHIP LGALSL LGALS4 LGALS3 LGALS2 IL36A LGALS1 IL36B OGFOD1 OGFOD2 TNFSF10 TNFSF11 IL12B IL12A LGALS9 LGALS8 LGALS7 HABP2 MUCL1 LMAN1L P3H2 P3H1 FLT3LG P3H3 EREG BTC SFRP4 SFRP1 SFRP2 ASTL SLPI IL23A CD109 PAPPA SFRP5 HMSD SDC2 EBI3 SDC3 A2M CTSA TNFSF18 TNFSF14 TNFSF15 REG4 TNFSF12 TNFSF13 IGF2 GDF2 IL36G CELA1 IGF1 GDF3 PPBP GDF6 GDF5 GDF7 IL1F10 CRNN GDF9 CD209 ARTN SDC1 TCHHL1 TDGF1 NODAL IFNA5 IL22 IFNA4 IFNA7 IL20 IFNA6 IFNA1 IL25 MSTN IL26 CTSZ IL24 IFNA2 CTSW CTSV CLEC9A PRL PCSK6 CHRDL2 PCSK5 CHRDL1 IFNA8 CTSS CTSO CTSL HYAL1 CTSK HYAL2 HYAL3 HYAL4 MUC12 CTSH MUC13 CTSG CTSF MUC15 CTSE CTSC CTSB IL10 SFTPB IL11 IL15 SFTPC SFTPD TGFB2 IL13 IL18 TGFB1 IL19 IL16 MMP23B IL1B TGFB3 FAM20B FAM20C FAM20A SPAM1 C1QB CSTB C1QA CSTA MEGF6 CST9 CST8 PTN CST7 CST6 CPN2 CST5 CST4 CST3 CST2 CST1 WIF1 GPC1 GPC3 GPC2 GPC5 GPC4 GPC6 GDF10 GDF11 IFNB1 IL37 IL34 VEGFB OSM VEGFC CSHL1 KAZALD1 VEGFA KITLG EPGN VWC2 IL17F IL17D MEGF8 IL17C IL17B C1QC IL17A MEGF9 FCN1 FCN2 FCN3 S100A7L2 CCL4L2 LOXL3 CLEC18C IHH LOXL4 CLEC18B PLAT LOXL1 CLEC18A SDC4 LOXL2 TGM1 TGM7 NRTN PLG TGM6 TGM5 PAMR1 FGF2 TGM4 FGF6 TGM3 TGM2 MDK WNT5B CCL5 ANXA13 WNT5A ADAM11 ANXA11 ADAM10 F2 ANXA10 MUC3A LGALS9C MMP9 LGALS9B ADAM19 CXCL12 ADAM18 ADAM17 EMCN ADAM12 LOX ADAM15 MASP2 MASP1 LPA HTRA3 CCL3L3 HTRA4 HTRA1 SCUBE2 WNT6 SCUBE3 BRINP2 SCUBE1 THPO FGF20 IL36RN WNT1 WNT2 BRINP3 FGF23 WNT3 FGF22 WNT4 FGF21 MUC16 PSPN WNT3A MUC17 CLEC17A A2ML1 INHBB INHBA BMP7 INHBC BMP6 BMP5 INHBE FGF17 BMP4 IL4 GH2 GH1 IL3 BMP3 FGF16 BMP2 IL6 BMP1 IL5 FGF14 GDNF IL7 FGF19 IL9 FGF18 FGF13 FGF12 MUC20 MUC21 FGF11 PDGFB MUC22 FGF10 CXCL6 CXCL9 CXCL8 WNT2B EDA MEGF10 MEGF11 NGLY1 PZP TCHH CLEC14A CXCL1 CXCL3 CXCL2 CXCL5 VWC2L GRIFIN CELA2A EGFL7 CELA2B MMP7 EGFL6 MMP1 MMP3 MMP8 WNT16 C1QTNF9B GREM1 IFNG IFNE LTA IFNK LTB EGFL8 PAPPA2 CST9L COLEC12 COLEC11 COLEC10 CLEC12A CLEC12B MUC1 WNT11 MUC7 MUC4 MUC6 S100G MUC5B S100B CFC1 PIK3IP1 S100Z S100P INS IL2 EGF MST1 IL1A SERPINE1 PLAU REG1A ADAMDEC1 PRSS1 CNTF SERPINE2 SERPINE3 CLEC10A ISM1 ISM2 CRHBP PRSS3 PRSS2 CCBE1 SERPINF1 SERPINF2 CLEC11A LGALS14 LGALS16 HCFC2 HCFC1 FLG2 LGALS13 LGALS12 SERPING1 FREM1 FREM2 FREM3 PROL1 FLG CELA3A CELA3B DHH PDGFA ADAMTS12 ADAMTS10 ADAMTS16 ADAMTS15 HPX ADAMTS14 ADAMTS13 ADAMTS19 S100A16 ADAMTS18 PDGFD ADAMTS17 PDGFC SERPINH1 S100A13 S100A12 S100A14 ELANE S100A11 S100A10 WNT10B ST14 WNT10A HRNR TNFSF4 SERPINI2 TNFSF9 F13B TNFSF8 SERPINI1 HRG SERPINA11 SERPINA2 SFTA2 SERPINA12 SFTA3 ANXA8L1 SERPINA1 WFIKKN1 SERPINA10 WFIKKN2 SERPINA9 C1QTNF9 SERPINA6 SERPINA7 AREG MMP21 SERPINA4 MMP20 SERPINA5 ADAMTSL1 C1QTNF4 C17orf58 C1QTNF3 SHH MMP25 C1QTNF2 MMP24 C1QTNF1 ADAMTSL5 MMP27 C1QTNF8 ADAMTSL4 MMP26 C1QTNF7 ADAMTSL3 C1QTNF6 ADAMTSL2 MMP28 PID_HIF1_TFPATHWAY%MSIGDB_C2%PID_HIF1_TFPATHWAY PID_HIF1_TFPATHWAY SERPINE1 EP300 SMAD4 SMAD3 CREB1 LEP NDRG1 JUN MCL1 CREBBP TF VEGFA SP1 TFRC CITED2 ITGB2 BHLHE41 EGLN1 SLC2A1 ADM RORA EGLN3 ENO1 ETS1 HK2 HK1 HNF4A CA9 PGM1 IGFBP1 CXCR4 NCOA1 NCOA2 EDN1 ARNT FOS PKM TFF3 PLIN2 ALDOA ABCG2 ENG PFKFB3 ABCB1 FECH FURIN GATA2 HIF1A HDAC7 CXCL12 LDHA NT5E PGK1 NPM1 HMOX1 NOS2 TERT BNIP3 CP GCK PFKL EPO COPS5 AKT1 ID2 BHLHE40 PID_NFKAPPAB_ATYPICAL_PATHWAY%MSIGDB_C2%PID_NFKAPPAB_ATYPICAL_PATHWAY PID_NFKAPPAB_ATYPICAL_PATHWAY NFKB1 PIK3CA LCK SSPO CSNK2A1 SYK SRC CSNK2A2 MAPK14 PIK3R1 IKBKB NFKBIA CSNK2B BCL3 RELA REL ARRB2 BIOCARTA_EPHA4_PATHWAY%MSIGDB_C2%BIOCARTA_EPHA4_PATHWAY BIOCARTA_EPHA4_PATHWAY EPHA4 FYN L1CAM ITGA1 EPHB1 RAP1B ITGB1 SELP LYN ACTA1 PID_ERBB_NETWORK_PATHWAY%MSIGDB_C2%PID_ERBB_NETWORK_PATHWAY PID_ERBB_NETWORK_PATHWAY BTC ERBB3 ERBB2 NRG1 AREG NRG2 ERBB4 EGF TGFA HBEGF EGFR NRG3 NRG4 HSP90AA1 EREG PID_ENDOTHELIN_PATHWAY%MSIGDB_C2%PID_ENDOTHELIN_PATHWAY PID_ENDOTHELIN_PATHWAY RHOA HRAS PRKCE ADCY4 ADCY3 JAK2 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 ADCY9 GNAL SRC EDNRB MAPK14 MAPK1 CDC42 JUN CRK MMP1 CYSLTR1 EDNRA CYSLTR2 PRKCG PRKCH MAP2K2 TRPC6 EDN3 PLA2G4A SLC9A3 PLCB3 PRKCQ PLCB1 RAF1 PLCB2 GNAZ EDN2 PRKCB GNAI3 GNAI1 PRKCA SLC9A1 GNAI2 GNA14 EDN1 MAPK8 GNA15 FOS GNA11 GNA12 PTK2B GNAO1 COL3A1 COL1A2 PRKCD GNAQ BCAR1 AKT1 RAC1 MAP2K1 MAPK3 BIOCARTA_FREE_PATHWAY%MSIGDB_C2%BIOCARTA_FREE_PATHWAY BIOCARTA_FREE_PATHWAY TNF NFKB1 CXCL8 RELA GSS GSR XDH GPX1 NOX1 SOD1 BIOCARTA_CYTOKINE_PATHWAY%MSIGDB_C2%BIOCARTA_CYTOKINE_PATHWAY BIOCARTA_CYTOKINE_PATHWAY TNF IL6 IL5 IL2 IL9 IL17A IFNG IFNA1 IL1A LTA IL10 CXCL8 IL15 IL12B IL12A IL13 IL18 IFNB1 IL16 IL4 IL3 BIOCARTA_STRESS_PATHWAY%MSIGDB_C2%BIOCARTA_STRESS_PATHWAY BIOCARTA_STRESS_PATHWAY TNF NFKB1 LTA ATF1 TRADD TANK CASP2 RIPK1 IKBKG MAP2K6 MAP2K3 MAP2K4 MAP4K2 MAP3K1 CHUK CRADD MAPK8 TRAF2 TNFRSF1A MAP3K14 MAPK14 IKBKB NFKBIA RELA JUN NABA_ECM_REGULATORS%MSIGDB_C2%NABA_ECM_REGULATORS NABA_ECM_REGULATORS TIMP2 TIMP3 TIMP1 TIMP4 SERPINB3 SERPINB4 SERPINB1 A2ML1 SERPINB2 SERPINB9 SERPINB7 PRSS12 SERPINB8 MMP10 SERPINB6 MMP12 F7 MMP11 MMP14 BMP1 MMP13 F9 MMP16 MMP15 MMP17 MMP19 SERPINB10 SERPINB11 SERPINB12 SERPINB13 NGLY1 PZP SERPINC1 ADAM22 ADAM21 ADAM20 CELA2A ADAM29 CELA2B ADAM28 MMP7 CST11 MMP1 ADAM23 MMP3 MMP8 P4HTM EGLN1 PAPPA2 CST9L EGLN3 EGLN2 CTSD F10 SERPIND1 F12 ADAM33 MMP2 SERPINB5 ADAM32 ADAM30 SULF1 AGT SULF2 PLOD3 F13A1 PLOD2 PLOD1 ADAM2 ADAM9 ADAM8 ADAM7 KNG1 CPAMD8 PI3 AMBP KY TMPRSS15 P4HA1 P4HA2 P4HA3 HPSE ADAMTS4 ADAMTS5 ADAMTS2 ADAMTS3 ADAMTS1 ADAMTS8 ADAMTS9 ADAMTS6 CSTL1 ADAMTS7 ADAMTS20 MEP1B MEP1A ITIH5 ITIH4 ITIH3 ITIH2 ITIH6 ITIH1 TLL2 TLL1 HPSE2 OGFOD1 OGFOD2 HABP2 P3H2 P3H1 P3H3 ASTL SLPI CD109 PAPPA HMSD A2M CTSA CELA1 CTSZ CTSW CTSV PCSK6 PCSK5 CTSS CTSO CTSL HYAL1 CTSK HYAL2 HYAL3 HYAL4 CTSH SERPINE1 CTSG CTSF CTSE CTSC CTSB PLAU MMP23B ADAMDEC1 PRSS1 FAM20B FAM20C SERPINE2 FAM20A SERPINE3 SPAM1 CSTB CSTA PRSS3 PRSS2 CST9 CST8 SERPINF1 SERPINF2 CST7 CST6 CPN2 CST5 CST4 CST3 CST2 CST1 SERPING1 CELA3A CELA3B ADAMTS12 ADAMTS10 ADAMTS16 ADAMTS15 ADAMTS14 KAZALD1 ADAMTS13 ADAMTS19 ADAMTS18 ADAMTS17 SERPINH1 ELANE ST14 LOXL3 SERPINI2 LOXL4 F13B PLAT SERPINI1 LOXL1 HRG SERPINA11 LOXL2 SERPINA2 TGM1 TGM7 SERPINA12 TGM6 PLG TGM5 SERPINA1 PAMR1 TGM4 SERPINA10 TGM3 TGM2 SERPINA9 SERPINA6 SERPINA7 ADAM11 MMP21 ADAM10 SERPINA4 F2 MMP20 SERPINA5 MMP9 ADAMTSL1 ADAM19 C17orf58 ADAM18 ADAM17 ADAM12 MMP25 LOX ADAM15 MMP24 MASP2 MASP1 ADAMTSL5 LPA MMP27 HTRA3 ADAMTSL4 HTRA4 MMP26 HTRA1 ADAMTSL3 ADAMTSL2 MMP28 PID_HIF1A_PATHWAY%MSIGDB_C2%PID_HIF1A_PATHWAY PID_HIF1A_PATHWAY CDKN2A ARNT TP53 HIF1A EGLN1 NAA10 CUL2 EGLN3 HIF3A GNB2L1 EGLN2 RBX1 OS9 COPS5 TCEB2 TCEB1 HIF1AN VHL HSP90AA1 PID_ANGIOPOIETIN_RECEPTOR_PATHWAY%MSIGDB_C2%PID_ANGIOPOIETIN_RECEPTOR_PATHWAY PID_ANGIOPOIETIN_RECEPTOR_PATHWAY PTPN11 TNF NFKB1 RPS6KB1 CDKN1A PIK3CA GRB2 ANGPT4 ANGPT2 ANGPT1 GRB7 PXN MAPK14 PAK1 MAPK1 NCK1 AGTR1 FYN CRK ELK1 GRB14 DOK2 ELF1 ELF2 FOXO1 PLD2 STAT5A STAT5B NOS3 BMX FES TNIP2 TEK ETS1 ITGB1 PLG MMP2 MAPK8 FGF2 FN1 F2 PTK2 SHC1 PIK3R1 ITGA5 RELA AKT1 RAC1 RASA1 MAPK3 BIOCARTA_G2_PATHWAY%MSIGDB_C2%BIOCARTA_G2_PATHWAY BIOCARTA_G2_PATHWAY CDKN2D PRKDC PLK1 CDC25C MYT1 YWHAQ CDKN1A CDC25B WEE1 CDC34 CHEK1 MDM2 CHEK2 CDK1 TP53 BRCA1 RPS6KA1 ATM YWHAH ATR CCNB1 EP300 GADD45A CDC25A BIOCARTA_IL3_PATHWAY%MSIGDB_C2%BIOCARTA_IL3_PATHWAY BIOCARTA_IL3_PATHWAY FOS HRAS GRB2 SOS1 STAT5A STAT5B SHC1 JAK2 CSF2RB IL3RA PTPN6 RAF1 MAP2K1 MAPK3 IL3 PID_RAS_PATHWAY%MSIGDB_C2%PID_RAS_PATHWAY PID_RAS_PATHWAY RASGRP1 RASGRP4 RASGRP3 RABGEF1 SYNGAP1 DAB2IP RASA4 RASA2 NF1 HRAS RIN1 SOS2 GRB2 SOS1 PRKCE PRKCB PRKCA LGALS3 LGALS1 NRAS PRKCZ RRAS CAMK2B RASGRF2 RASA1 RASGRF1 KRAS RASAL1 PLCE1 RASGRP2 BIOCARTA_IL2_PATHWAY%MSIGDB_C2%BIOCARTA_IL2_PATHWAY BIOCARTA_IL2_PATHWAY MAPK8 FOS IL2 ELK1 LCK IL2RA IL2RB HRAS CSNK2A1 GRB2 SYK SOS1 STAT5A STAT5B SHC1 IL2RG JUN RAF1 MAP2K1 JAK3 MAPK3 JAK1 PID_ERBB2_ERBB3_PATHWAY%MSIGDB_C2%PID_ERBB2_ERBB3_PATHWAY PID_ERBB2_ERBB3_PATHWAY PTPN11 MTOR ERBB3 PIK3CA ERBB2 HRAS GRB2 SOS1 MAP2K2 JAK2 RAF1 CHRNA1 DOCK7 PIK3CD PRKACA PIK3R3 PIK3R2 PIK3CB MAPK8 MAPK9 PPP3CB CHRNE FOS USP8 BAD STAT3 NFATC4 RNF41 NRG1 MAPK10 NRG2 NF2 SRC SHC1 PIK3R1 NRAS MAPK1 CDC42 JUN AKT1 RAC1 MAP2K1 MAPK3 KRAS BIOCARTA_AKAP95_PATHWAY%MSIGDB_C2%BIOCARTA_AKAP95_PATHWAY BIOCARTA_AKAP95_PATHWAY CCNB1 PRKAR2B PRKAG1 CDK1 AKAP8 PRKACG DDX5 PRKAR2A PPP1CA PPP2CA NCAPD2 PRKACB PID_IL2_STAT5_PATHWAY%MSIGDB_C2%PID_IL2_STAT5_PATHWAY PID_IL2_STAT5_PATHWAY PTPN11 CDK6 GAB2 IL2 PIK3CA SP1 LCK IL2RA IL2RB ELF1 BCL2 GRB2 SOS1 FASLG CCND3 STAT5A STAT5B BCL2L1 LTA IL4 CCNA2 SHC1 PIK3R1 IL2RG MYC JAK3 PRF1 JAK1 CCND2 FOXP3 PID_PDGFRA_PATHWAY%MSIGDB_C2%PID_PDGFRA_PATHWAY PID_PDGFRA_PATHWAY RAPGEF1 FOS CRK PDGFRA CAV3 PIK3CA SRF ELK1 SHB CRKL SHF CSNK2A1 GRB2 PLCG1 SOS1 IFNG SHC1 PIK3R1 JUN CAV1 ITGAV JAK1 PID_REELIN_PATHWAY%MSIGDB_C2%PID_REELIN_PATHWAY PID_REELIN_PATHWAY RAPGEF1 FYN PIK3CA CRKL LRPAP1 VLDLR CBL GSK3B LRP8 GRIN2A RELN ITGB1 NCK2 MAP2K7 GRIN2B MAPK8IP1 DAB1 CDK5 MAP1B MAPK8 ARHGEF2 MAPT MAP3K11 CDK5R1 PAFAH1B1 PIK3R1 ITGA3 RAP1A AKT1 BIOCARTA_P38MAPK_PATHWAY%MSIGDB_C2%BIOCARTA_P38MAPK_PATHWAY BIOCARTA_P38MAPK_PATHWAY DAXX MEF2C STAT1 DDIT3 MAPKAPK2 TGFBR1 RAPGEF2 MAPKAPK5 ELK1 HRAS GRB2 PLA2G4A TRADD TGFB2 MAX RIPK1 TGFB1 MAP2K6 RPS6KA5 MAP2K4 TGFB3 CREB1 MAP3K1 TRAF2 MEF2D SHC1 MAPK14 CDC42 ATF2 MYC HSPB2 HSPB1 MEF2BNB-MEF2B MKNK1 RAC1 MAP3K9 MAP3K7 MAP3K5 HMGN1 MEF2A BIOCARTA_RB_PATHWAY%MSIGDB_C2%BIOCARTA_RB_PATHWAY BIOCARTA_RB_PATHWAY CDC25C RB1 MYT1 CDC25B WEE1 CDK2 CHEK1 CDK1 TP53 ATM YWHAH MAPK14 CDK4 BIOCARTA_MET_PATHWAY%MSIGDB_C2%BIOCARTA_MET_PATHWAY BIOCARTA_MET_PATHWAY PTPN11 RAPGEF1 CRK PIK3CA ELK1 CRKL HRAS GRB2 SOS1 PTEN MAP2K2 PIK3CG RAF1 ITGB1 MAP4K1 GAB1 DOCK1 MAPK8 HGF FOS PTK2B STAT3 MET PXN SRC PTK2 PIK3R1 PAK1 ITGA1 MAPK1 RAP1B RAP1A JUN MAP2K1 MAPK3 RASA1 ACTA1 BIOCARTA_ACE2_PATHWAY%MSIGDB_C2%BIOCARTA_ACE2_PATHWAY BIOCARTA_ACE2_PATHWAY ACE CMA1 ACE2 REN AGTR2 AGT COL4A2 COL4A1 COL4A4 COL4A3 COL4A6 COL4A5 AGTR1 BIOCARTA_STATHMIN_PATHWAY%MSIGDB_C2%BIOCARTA_STATHMIN_PATHWAY BIOCARTA_STATHMIN_PATHWAY CDK1 CAMK2D CAMK2A CD3G CD3E CD3D MAPK13 CD2 CCNB1 CAMK4 CD247 CAMK2G PRKAR1B PRKAR2B PRKAR1A CAMK2B PRKACG PRKAR2A PRKACB PID_P38_ALPHA_BETA_PATHWAY%MSIGDB_C2%PID_P38_ALPHA_BETA_PATHWAY PID_P38_ALPHA_BETA_PATHWAY PAK3 FYN PRKG1 MAP3K3 YES1 DUSP8 FGR MAPK11 RALA HCK LCK TRAF6 CCM2 MAP3K12 RIPK1 MAP2K6 MAP2K3 MAP2K4 PAK2 DUSP1 TAB1 SRC MAPK14 PAK1 CDC42 RAC1 BLK RALB DUSP16 LYN DUSP10 BIOCARTA_41BB_PATHWAY%MSIGDB_C2%BIOCARTA_41BB_PATHWAY BIOCARTA_41BB_PATHWAY TRAF2 MAPK8 NFKB1 IL2 IFNG MAPK14 IKBKB NFKBIA RELA ATF2 JUN TNFRSF9 IL4 MAP4K5 MAP3K1 MAP3K5 CHUK BIOCARTA_SALMONELLA_PATHWAY%MSIGDB_C2%BIOCARTA_SALMONELLA_PATHWAY BIOCARTA_SALMONELLA_PATHWAY ACTR3 ACTR2 ARPC1B ARPC1A ARPC4 ARPC5 ARPC2 ARPC3 WASL CDC42 WASF1 RAC1 ACTA1 PID_HNF3B_PATHWAY%MSIGDB_C2%PID_HNF3B_PATHWAY PID_HNF3B_PATHWAY G6PC HMGCS1 KCNJ11 PKLR ABCC8 FOXF1 PDX1 APOA1 SP1 HNF1B NF1 HNF1A CPT1C CPT1B DLK1 INS BDH1 ALB TFRC ALDOB FOXA3 FOXA2 FOXA1 HNF4A CREB1 IGFBP1 CEBPA F2 AFP CEBPB ACADVL ALAS1 CEBPD TAT SLC2A2 GCK NR3C1 TTR UCP2 AKT1 NKX2-1 ACADM PCK1 HADH CPT1A PID_IL4_2PATHWAY%MSIGDB_C2%PID_IL4_2PATHWAY PID_IL4_2PATHWAY MTOR RPS6KB1 PIK3CA GRB2 BCL2L1 IL10 JAK2 IL4 IL5 ITGB3 MAPK14 PIGR SPI1 IRS1 IRS2 IL13RA2 MYBL1 IL13RA1 CCL11 IL4R ARG1 GTF3A OPRM1 FCER2 SELP IRF4 RETNLB ALOX15 THY1 SOCS3 SOCS1 INPP5D STAT6 SOCS5 BCL6 EGR2 SP1 HMGA1 DOK2 PARP14 AICDA COL1A1 CD40LG STAT5A CCL17 STAT5B LTA FES CBL ETS1 TFF3 COL1A2 SHC1 PIK3R1 IL2RG CCL26 CEBPB PTPN6 MYB AKT1 JAK3 JAK1 PID_NCADHERIN_PATHWAY%MSIGDB_C2%PID_NCADHERIN_PATHWAY PID_NCADHERIN_PATHWAY PTPN11 AXIN1 RHOA PIK3CA PLCG1 MAPK8 CTNNB1 ROCK1 GRIA2 CTNND1 DAGLA DCTN1 LRP5 PIK3R1 GJA1 CDH2 CNR1 KIF5B CAMK2G PTPN1 FGFR1 GSN JUP CDC42 GAP43 FER CTTN MYL2 CTNNA1 MAPRE1 RAC1 DAGLB PIP5K1C BIOCARTA_HIF_PATHWAY%MSIGDB_C2%BIOCARTA_HIF_PATHWAY BIOCARTA_HIF_PATHWAY EDN1 ARNT VEGFA ASPH HIF1A P4HB NOS3 LDHA EP300 JUN EPO COPS5 CREB1 VHL HSP90AA1 PID_LYMPH_ANGIOGENESIS_PATHWAY%MSIGDB_C2%PID_LYMPH_ANGIOGENESIS_PATHWAY PID_LYMPH_ANGIOGENESIS_PATHWAY CRK MAPK11 PIK3CA COL1A1 GRB2 SOS1 FLT4 ITGB1 MAP2K4 CREB1 COL1A2 FN1 RPS6KA1 SHC1 MAPK14 PIK3R1 ITGA4 ITGA2 ITGA5 ITGA1 MAPK1 FIGF AKT1 MAPK3 VEGFC BIOCARTA_P35ALZHEIMERS_PATHWAY%MSIGDB_C2%BIOCARTA_P35ALZHEIMERS_PATHWAY BIOCARTA_P35ALZHEIMERS_PATHWAY MAPT APP CAPNS1 CDK5R1 CSNK1A1 CAPNS2 CSNK1D GSK3B CAPN1 CDK5 PPP2CA PID_WNT_SIGNALING_PATHWAY%MSIGDB_C2%PID_WNT_SIGNALING_PATHWAY PID_WNT_SIGNALING_PATHWAY WNT1 WNT2 WNT3 WNT3A FZD10 LRP6 WNT7B RSPO1 CTHRC1 FZD1 FZD2 FZD5 WNT7A IGFBP4 RYK FZD4 ATP6AP2 WNT5A FZD6 DKK1 FZD7 FZD9 KREMEN1 FZD8 KREMEN2 ROR2 LRP5 WIF1 BIOCARTA_BARRESTIN_SRC_PATHWAY%MSIGDB_C2%BIOCARTA_BARRESTIN_SRC_PATHWAY BIOCARTA_BARRESTIN_SRC_PATHWAY ARRB1 GNGT1 GNB1 HCK HRAS SRC MAP2K2 ADCY1 MAPK1 PLCB1 RAF1 DNM1 MAP2K1 MAPK3 GNAS PID_ALPHA_SYNUCLEIN_PATHWAY%MSIGDB_C2%PID_ALPHA_SYNUCLEIN_PATHWAY PID_ALPHA_SYNUCLEIN_PATHWAY FYN YES1 FGR MAOB PARK7 HCK LCK PARK2 SLC6A3 PLD1 UBE2L3 KLK6 PLD2 UCHL1 GRK5 SNCA TOR1A SNCAIP TH STUB1 PLCB2 FKBP1A PTK2B BAD PRKCD CSNK2A1 SYK SRC MAPK1 PPP2R5D BLK MAPK3 LYN BIOCARTA_VDR_PATHWAY%MSIGDB_C2%BIOCARTA_VDR_PATHWAY BIOCARTA_VDR_PATHWAY MED1 NCOR1 EP300 NCOA3 RXRA TSC2 CARM1 CREBBP HDAC1 NCOA1 NCOA2 KAT2B BIOCARTA_PDGF_PATHWAY%MSIGDB_C2%BIOCARTA_PDGF_PATHWAY BIOCARTA_PDGF_PATHWAY STAT1 STAT6 PDGFRA PIK3CA SRF ELK1 HRAS PLCG1 GRB2 SOS1 STAT5A STAT5B PIK3CG RAF1 MAP2K4 PRKCB MAP3K1 PRKCA MAPK8 FOS STAT3 STAT4 STAT2 CSNK2A1 SHC1 PIK3R1 JUN PDGFA MAP2K1 MAPK3 RASA1 JAK1 BIOCARTA_GRANULOCYTES_PATHWAY%MSIGDB_C2%BIOCARTA_GRANULOCYTES_PATHWAY BIOCARTA_GRANULOCYTES_PATHWAY TNF ITGAM SELPLG ITGAL ICAM1 IFNG C5 IL1A SELL PECAM1 ITGB2 CXCL8 CSF3 SELP PID_AMB2_NEUTROPHILS_PATHWAY%MSIGDB_C2%PID_AMB2_NEUTROPHILS_PATHWAY PID_AMB2_NEUTROPHILS_PATHWAY JAM3 THY1 TNF FYN PLAUR TLN1 MST1R NFKB1 MYH2 YES1 RHOA FGR HCK LCK MST1 PLAU ITGB2 PLAT PLG MMP2 IL6 ROCK1 ITGAM SELPLG MMP9 SRC ICAM1 PRKCZ LPA RAP1B RAP1A AKT1 LRP1 CTGF BLK HMGB1 AGER SELP APOB LYN JAM2 BIOCARTA_BAD_PATHWAY%MSIGDB_C2%BIOCARTA_BAD_PATHWAY BIOCARTA_BAD_PATHWAY KITLG PIK3CA BAX BCL2 IGF1R YWHAH KIT BCL2L1 ADCY1 PIK3CG IGF1 IL3 BAD RPS6KA1 PIK3R1 MAPK1 CSF2RB IL3RA PRKAR1B PRKAR2B AKT1 PRKAR1A PRKACG PRKAR2A MAPK3 PRKACB ST_TUMOR_NECROSIS_FACTOR_PATHWAY%MSIGDB_C2%ST_TUMOR_NECROSIS_FACTOR_PATHWAY ST_TUMOR_NECROSIS_FACTOR_PATHWAY TNF MAP3K3 NFKB1 TONSL TNFAIP3 NR2C2 BAG4 CASP8 TRADD CASP3 FADD AGFG1 RIPK1 RALBP1 IKBKG NFKBIL1 CFLAR TNFRSF1B MAP2K4 NFKB2 NFKBIE BIRC2 BIRC3 NFKBIB TRAF2 TNFRSF1A NFKBIA JUN MAP3K7 PID_FOXM1_PATHWAY%MSIGDB_C2%PID_FOXM1_PATHWAY PID_FOXM1_PATHWAY CDKN2A XRCC1 RB1 BRCA2 SP1 CDK2 CDK1 EP300 CDK4 SKP2 CCNA2 MMP2 FOS PLK1 CCNE1 CENPA CDC25B AURKB CHEK2 TGFA CCNB1 GSK3A ONECUT1 FOXM1 CENPB CKS1B CCNB2 CCND1 MYC NEK2 NFATC3 ESR1 LAMA4 CREBBP MAP2K1 ETV5 CENPF GAS1 BIRC5 HIST1H2BA BIOCARTA_ARF_PATHWAY%MSIGDB_C2%BIOCARTA_ARF_PATHWAY BIOCARTA_ARF_PATHWAY CDKN2A RB1 PIK3CA MDM2 TP53 TWIST1 TBX2 PIK3R1 POLR1A POLR1B POLR1C POLR1D ABL1 MYC PIK3CG E2F1 RAC1 PID_TXA2PATHWAY%MSIGDB_C2%PID_TXA2PATHWAY PID_TXA2PATHWAY RHOA LCK EGF PRKCE PIK3CG PRKACA ROCK1 SYK SRC MAPK14 DNM1 BLK LYN PRKG1 FYN GNB1 YES1 FGR MAPK11 HCK PRKCG PRKCH NOS3 PRKCQ PLCB2 ARR3 PRKCB PTGDR PTGIR PRKCA ARHGEF1 GNAI2 PIK3R6 GNA14 PIK3R5 GNA13 GNA15 SLC9A3R1 GNA11 TGM2 GNG2 GNA12 TBXA2R ADRBK2 ADRBK1 VCAM1 PRKCD SELE GNAQ RAB11A GNB5 ICAM1 EGFR PRKCZ ARRB2 AKT1 RAC1 PID_ERBB4_PATHWAY%MSIGDB_C2%PID_ERBB4_PATHWAY PID_ERBB4_PATHWAY BTC NEDD4 FYN PIK3CA ERBB2 MDM2 YAP1 ERBB4 GRB2 STAT5A STAT5B JAK2 GRIN2B WWP1 PIK3CD PIK3R3 PIK3R2 PIK3CB ITCH NCOR1 TAB2 NRG1 NRG2 SHC1 PIK3R1 ADAM17 HBEGF NRG3 MAPK1 NRG4 PRL LRIG1 MAPK3 WWOX CBFA2T3 PRLR EREG DLG4 BIOCARTA_CREB_PATHWAY%MSIGDB_C2%BIOCARTA_CREB_PATHWAY BIOCARTA_CREB_PATHWAY PIK3CA HRAS CAMK2A GRB2 SOS1 ADCY1 RPS6KA5 PRKCB CREB1 PRKCA CAMK2D RPS6KA1 MAPK14 PIK3R1 CAMK2G MAPK1 PRKAR1B PRKAR2B AKT1 PRKAR1A CAMK2B PRKACG RAC1 PRKAR2A MAPK3 GNAS PRKACB PID_IL8_CXCR2_PATHWAY%MSIGDB_C2%PID_IL8_CXCR2_PATHWAY PID_IL8_CXCR2_PATHWAY ARRB1 PDPK1 GNB1 FGR PPP2R1A HCK CXCR2 RAC2 VASP ELMO1 PLD2 DOCK2 RAB5A PRKCG RAB7A PPP2CA CBL PLCB3 PLCB1 PIK3CG PLCB2 PRKCB PRKCA GNAI2 PIK3R6 GNA14 GNA15 GNG2 RAB11A CXCL8 ARRB2 AKT1 DNM1 LYN BIOCARTA_EPO_PATHWAY%MSIGDB_C2%BIOCARTA_EPO_PATHWAY BIOCARTA_EPO_PATHWAY MAPK8 FOS ELK1 HRAS CSNK2A1 GRB2 PLCG1 SOS1 STAT5A STAT5B SHC1 JAK2 EPOR PTPN6 JUN RAF1 EPO MAP2K1 MAPK3 BIOCARTA_UCALPAIN_PATHWAY%MSIGDB_C2%BIOCARTA_UCALPAIN_PATHWAY BIOCARTA_UCALPAIN_PATHWAY TLN1 RHOA CAPNS1 CAPNS2 ACTN1 PXN SRC PTK2 ITGB3 ITGA1 CAPN1 ITGB1 ACTN3 ACTN2 RAC1 EZR SPTAN1 ACTA1 PID_NEPHRIN_NEPH1_PATHWAY%MSIGDB_C2%PID_NEPHRIN_NEPH1_PATHWAY PID_NEPHRIN_NEPH1_PATHWAY FYN PIK3CA PLCG1 GRB2 PARD6A TRPC6 NCK2 MAP2K4 PIK3CD PIK3R3 PIK3R2 PIK3CB MAPK8 MAPK9 PRKCI KIRREL CD2AP BAD TJP1 NPHS1 NPHS2 F2RL2 MAPK10 WASL PIK3R1 PRKCZ JUN NCK1 ARRB2 AKT1 RAC1 BIOCARTA_THELPER_PATHWAY%MSIGDB_C2%BIOCARTA_THELPER_PATHWAY BIOCARTA_THELPER_PATHWAY PTPRC ITGB2 CD28 THY1 CD247 CD3G ITGAL CD3E CD3D ICAM1 CD2 CD4 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY%MSIGDB_C2%ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY CDKN2A BTK YWHAB IARS INPP5D YWHAQ RPS6KB1 PIK3CA YWHAG SOS2 YWHAH GRB2 PPP1R13B FOXO1 SOS1 PTEN YWHAZ GSK3B IGFBP1 BAD RPS6KA1 SHC1 GSK3A SFN DAPP1 A1BG YWHAE CYTH3 RPS6KA3 RPS6KA2 AKT2 AKT1 AKT3 EXOSC1 CD55 PDK1 NR4A3 PID_CASPASE_PATHWAY%MSIGDB_C2%PID_CASPASE_PATHWAY PID_CASPASE_PATHWAY TNF VIM BAX BCL2 XIAP CASP7 APP CASP8 TRADD CASP3 CASP2 APAF1 RIPK1 SPTAN1 BIRC2 MAP3K1 BIRC3 CRADD TRAF2 TNFRSF1A PRF1 ACTA1 NUMA1 LMNB2 LMNB1 PIDD1 CASP9 CASP6 SLK CASP10 CFL2 CASP4 ARHGDIB CASP1 SREBF1 DFFB DFFA PARP1 MADD GAS2 TOP1 SATB1 DIABLO LMNA TFAP2A LIMK1 GZMB KRT18 CYCS PTK2 GSN BID PID_CDC42_PATHWAY%MSIGDB_C2%PID_CDC42_PATHWAY PID_CDC42_PATHWAY PAX6 SEPT2 ENAH TIAM1 MTOR ARHGEF7 APC ARHGEF6 RPS6KB1 PIK3CA IQGAP3 HES5 PAK4 HRAS LIMK2 TNK2 BRAF CDC42BPA BAIAP2 DLG1 PRKCE DIAPH3 PARD6A MAP2K6 MAP2K3 MAP2K4 MAP3K1 MAPK9 CTNNB1 F2RL2 WASL SRC MAPK14 PAK1 EXOC7 IQGAP1 MAPK1 CDC42 JUN CDH1 CTNNA1 VAV2 YES1 PLD1 CBL GSK3B RAF1 MAP2K7 PAK2 MAPK8 ACTR3 LIMK1 MAP3K11 ACTR2 ARPC1B ARPC4 ARPC5 ARPC2 ARPC3 BCAR1 PIK3R1 PRKCZ ATF2 MYL2 RAC1 MAPK3 RASGRF1 EPS8 ARHGDIA CFL1 BIOCARTA_VEGF_PATHWAY%MSIGDB_C2%BIOCARTA_VEGF_PATHWAY BIOCARTA_VEGF_PATHWAY VEGFA PIK3CA HRAS PLCG1 NOS3 FLT4 PIK3CG PRKCB PRKCA ARNT FLT1 ELAVL1 KDR EIF2B1 EIF2B5 EIF2B4 PXN EIF2B3 EIF2B2 EIF1AX EIF2S2 EIF2S1 PTK2 SHC1 HIF1A EIF1 PIK3R1 EIF2S3 VHL BIOCARTA_AKT_PATHWAY%MSIGDB_C2%BIOCARTA_AKT_PATHWAY BIOCARTA_AKT_PATHWAY PDPK1 NFKB1 BAD PIK3CA YWHAH FOXO1 FASLG PIK3R1 PPP2CA IKBKB NFKBIA FOXO3 CASP9 RELA PIK3CG IKBKG AKT1 GH1 FOXO4 HSP90AA1 CHUK GHR BIOCARTA_RAB_PATHWAY%MSIGDB_C2%BIOCARTA_RAB_PATHWAY BIOCARTA_RAB_PATHWAY RAB2A RAB1A RAB4A RAB3A RAB1B RAB27A RAB9A RAB6A RAB11A RAB8A RAB5A RAB7A ACTA1 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES%MSIGDB_C2%SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES YWHAB MTOR YWHAQ RPS6KB1 PIK3CA CDKN1B PAK4 YWHAG SOS2 YWHAH GRB2 SOS1 YWHAZ BCL2L1 PARD6A GAB1 CREB1 PIK3CD TSC2 BAD F2RL2 SLC2A4 PAK1 GSK3A IRS1 SFN IRS2 CDC42 CYTH3 RPS6KA3 RPS6KA2 GADD45A AKT2 AKT3 PDK1 PAK3 CDKN2A CDK2 ERBB4 PPP1R13B PTEN INPPL1 IRS4 PREX1 GSK3B TSC1 CREB3 IFI27 PARD3 CREB5 IGF1 NOLC1 EBP PAK2 IGFBP1 PAK7 PAK6 PIK3R5 MET RPS6KA1 PTK2 SHC1 FOXO3 PTPN1 YWHAE MYC AKT1 PID_SYNDECAN_3_PATHWAY%MSIGDB_C2%PID_SYNDECAN_3_PATHWAY PID_SYNDECAN_3_PATHWAY FYN PTN SRC SDC3 EGFR PSENEN CXCL8 NCAN CASK PSEN1 MC4R APH1A CTTN POMC NCSTN APH1B AGRP PID_AURORA_A_PATHWAY%MSIGDB_C2%PID_AURORA_A_PATHWAY PID_AURORA_A_PATHWAY TACC1 ARHGEF7 OAZ1 FZR1 MDM2 GIT1 BRCA1 DLGAP5 NDEL1 TDRD7 CKAP5 TPX2 CPEB1 TACC3 AURKAIP1 AJUBA RAN GSK3B PRKACA CENPA CDC25B AURKB TP53 AURKA PAK1 NFKBIA PPP2R5D GADD45A AKT1 RASA1 BIRC5 PID_MYC_ACTIV_PATHWAY%MSIGDB_C2%PID_MYC_ACTIV_PATHWAY PID_MYC_ACTIV_PATHWAY TRRAP BAX NBN EP300 TK1 SMAD4 CDK4 SMAD3 CDC25A KAT2A EIF4A1 BMI1 PEG10 PIM1 UBTF RCC1 DDX18 CAD BCAT1 TP53 PTMA GAPDH SHMT1 ODC1 EIF2S1 RPL11 AK6 IREB2 CDCA7 CCNB1 HSPD1 MTDH PRDX3 PMAIP1 E2F3 NME1-NME2 MYCT1 MTA1 NME1 PDCD10 EIF4E HSPA4 HUWE1 CREBBP KIR3DL1 MINA FOSL1 CCND2 LIN28B GPAM POLR3D NDUFAF2 SNAI1 TAF4B PFKM EIF4G1 HMGA1 TFRC SLC2A1 ENO1 MAX KAT5 SERPINI1 RUVBL2 RUVBL1 TAF12 TAF10 ACTL6A SUPT7L SUPT3H MMP9 LDHA NPM1 TERT MYC ID2 NCL HSP90AA1 BIRC5 BIOCARTA_HER2_PATHWAY%MSIGDB_C2%BIOCARTA_HER2_PATHWAY BIOCARTA_HER2_PATHWAY IL6 STAT3 PIK3CA ERBB3 CARM1 ERBB4 HRAS GRB2 GRIP1 SOS1 IL6ST SHC1 IL6R PIK3R1 EGFR EP300 MAPK1 PIK3CG RAF1 ESR1 MAP2K1 MAPK3 BIOCARTA_PTC1_PATHWAY%MSIGDB_C2%BIOCARTA_PTC1_PATHWAY BIOCARTA_PTC1_PATHWAY CCNB1 SHH CDK7 XPO1 CCNH CDC25C PTCH1 MNAT1 CDC25B CDK1 CDC25A BIOCARTA_BIOPEPTIDES_PATHWAY%MSIGDB_C2%BIOCARTA_BIOPEPTIDES_PATHWAY BIOCARTA_BIOPEPTIDES_PATHWAY GNGT1 FYN STAT1 GNB1 STAT6 HRAS CAMK2A PLCG1 GRB2 SOS1 STAT5A STAT5B MAP2K2 JAK2 RAF1 PRKCB GNAI1 PRKCA CDK5 MAPK8 MAPT GNA11 PTK2B AGTR2 STAT3 STAT4 CALM3 STAT2 AGT CALM1 CALM2 MYLK CAMK2D F2 SHC1 MAPK14 KNG1 CAMK2G MAPK1 CAMK2B MAP2K1 MAPK3 PID_TNF_PATHWAY%MSIGDB_C2%PID_TNF_PATHWAY PID_TNF_PATHWAY MAP4K3 TNF STAT1 TRAF1 MAP3K3 NFKB1 CYLD TNIK SQSTM1 NSMAF TNFAIP3 BAG4 CASP8 TRADD FADD RIPK1 IKBKG MAP2K7 MAP2K3 TNFRSF1B MAP4K5 MADD MAP4K2 MAP3K1 BIRC2 CHUK BIRC3 TRAF2 PRKCI TNFRSF1A TAB2 TAB1 IKBKB ADAM17 PRKCZ RELA SMPD1 GNB2L1 MAP4K4 CAV1 NRK TXN MAP3K7 MAP3K5 SMPD2 RFFL PID_P38_MK2_PATHWAY%MSIGDB_C2%PID_P38_MK2_PATHWAY PID_P38_MK2_PATHWAY YWHAB MAPKAPK2 TSC2 YWHAQ CDC25B MAPK11 SRF YWHAG YWHAH MAPK14 YWHAZ ETV1 LSP1 TH MAPKAPK3 TCF3 SFN YWHAE RAF1 HSPB1 CREB1 BIOCARTA_NOS1_PATHWAY%MSIGDB_C2%BIOCARTA_NOS1_PATHWAY BIOCARTA_NOS1_PATHWAY PPP3CA PPP3CB PPP3CC CALM3 CALM1 CALM2 GRIN2A PRKAR1B GRIN2C PRKAR2B GRIN2D GRIN1 PRKAR1A PRKCB GRIN2B PRKACG NOS1 PRKAR2A PRKCA DLG4 PRKACB BIOCARTA_TCYTOTOXIC_PATHWAY%MSIGDB_C2%BIOCARTA_TCYTOTOXIC_PATHWAY BIOCARTA_TCYTOTOXIC_PATHWAY PTPRC CD8A ITGB2 CD28 THY1 CD247 CD3G ITGAL CD3E CD3D ICAM1 CD2 NABA_SECRETED_FACTORS%MSIGDB_C2%NABA_SECRETED_FACTORS NABA_SECRETED_FACTORS THPO FGF20 IL36RN WNT1 WNT2 BRINP3 FGF23 WNT3 FGFBP3 FGF22 WNT4 PF4V1 FGF21 PSPN WNT3A FGFBP1 LEFTY1 FGFBP2 INHBB INHBA BMP7 INHBC BMP6 BMP5 WNT9B INHBE FGF17 WNT9A BMP4 IL4 GH2 GH1 IL3 BMP3 FGF16 S100A2 BMP2 HGF IL6 IL5 FGF14 GDNF ANGPTL7 IL7 FGF19 ANGPTL6 IL9 FGF18 ANGPTL3 FGF13 FGF12 ANGPTL2 TGFA ANGPTL5 ANGPTL4 FGF11 PDGFB ANGPTL1 HBEGF FGF10 CXCL6 CCL14 CXCL9 CXCL8 CCL13 WNT2B EDA FIGF MEGF10 MEGF11 CCL11 CTF1 TCHH WNT8A CXCL1 CXCL3 LIF WNT8B CXCL2 CXCL5 FSTL1 VWC2L FSTL3 NTF4 EGFL7 EGFL6 FRZB NTF3 CCL19 WNT16 CCL18 C1QTNF9B LEFTY2 IFNG CCL17 IFNE CX3CL1 CCL16 LTA CCL15 IFNK CCL25 LTB EGFL8 CCL24 CCL23 CCL22 CCL21 CCL20 WNT11 WNT7B BMP8A S100G WNT7A S100B BMP8B CFC1 PIK3IP1 S100Z S100P CLCF1 CRLF3 INHA CCL28 CCL27 CRLF1 PF4 CCL26 CSF3 CSF2 CSF1 EPO GDF15 CXCL13 FGF1 TNF CXCL14 FGF3 FGF4 FGF5 FGF7 FGF8 FGF9 RPTN IFNA13 IFNA14 S100A1 IFNA16 FST IFNA17 PGF S100A6 S100A5 S100A4 S100A3 S100A9 S100A8 S100A7 IFNA10 CSH2 CSH1 CHRD TPO IFNA21 BDNF IFNW1 CXCL10 CXCL11 INS-IGF2 BMP10 FASLG INS TNFSF13B BMP15 S100A7A INSL6 INSL3 AMH HGFAC INSL5 CFC1B ZFP91 NRG1 NRG2 NGF NRG3 NRG4 XCL2 XCL1 CERS1 IL2 CCL8 CCL7 EGF MST1 CCL4 CCL3 IL1A CCL2 CCL1 ANGPT4 ANGPT2 ANGPT1 LEP CBLN4 CBLN3 CBLN2 CBLN1 IL1RN HHIP IL36A IL36B TNFSF10 TNFSF11 IL12B IL12A FLT3LG EREG BTC SFRP4 SFRP1 SFRP2 IL23A SFRP5 EBI3 TNFSF18 TNFSF14 TNFSF15 TNFSF12 TNFSF13 IGF2 GDF2 IL36G IGF1 GDF3 PPBP GDF6 GDF5 GDF7 IL1F10 CRNN GDF9 ARTN TCHHL1 TDGF1 NODAL IFNA5 IL22 IFNA4 IFNA7 IL20 IFNA6 IFNA1 IL25 MSTN IL26 IL24 IFNA2 PRL CHRDL2 CHRDL1 IFNA8 IL10 IL11 IL15 TGFB2 IL13 IL18 TGFB1 IL19 IL16 IL1B TGFB3 CNTF ISM1 ISM2 CRHBP MEGF6 CCBE1 PTN HCFC2 HCFC1 FLG2 WIF1 FLG GDF10 GDF11 DHH IFNB1 PDGFA IL37 IL34 VEGFB OSM VEGFC CSHL1 VEGFA KITLG S100A16 EPGN VWC2 PDGFD IL17F IL17D PDGFC MEGF8 IL17C S100A13 IL17B S100A12 S100A14 IL17A MEGF9 S100A11 S100A10 WNT10B S100A7L2 WNT10A CCL4L2 HRNR TNFSF4 IHH TNFSF9 TNFSF8 NRTN WFIKKN1 FGF2 FGF6 WFIKKN2 WNT5B MDK CCL5 WNT5A AREG CXCL12 SHH CCL3L3 SCUBE2 WNT6 SCUBE3 BRINP2 SCUBE1 PID_GLYPICAN_1PATHWAY%MSIGDB_C2%PID_GLYPICAN_1PATHWAY PID_GLYPICAN_1PATHWAY FYN VEGFA YES1 TGFBR1 TGFBR2 FGR HCK LCK APP SMAD2 TGFB2 TGFB1 TGFB3 FGF2 SLIT2 FLT1 PRNP PLA2G2A TDGF1 NRG1 SRC GPC1 FGFR1 SERPINC1 LAMA1 BLK LYN NABA_ECM_GLYCOPROTEINS%MSIGDB_C2%NABA_ECM_GLYCOPROTEINS NABA_ECM_GLYCOPROTEINS RSPO1 CTHRC1 IGFBP4 IGFBP3 SPP1 SLIT2 VIT SPON2 SPON1 SPARC DMP1 GLDN TSKU HMCN2 EYS VWA5B2 VWA5B1 FNDC7 FNDC8 CRISPLD1 FNDC1 CRISPLD2 ANOS1 SPARCL1 MXRA5 DDX26B OTOG CILP BSPH1 SRPX ECM1 ECM2 TINAGL1 ELN RSPO2 RSPO3 TINAG RSPO4 SBSPON VWA5A VWA9 CDCP2 NOV PXDN MATN1 VWA1 VWA2 CRELD1 MFGE8 CRELD2 GAS6 MATN4 MATN3 MATN2 VWA7 RELN TNXB VWCE EGFLAM SRPX2 BGLAP ABI3BP CILP2 VWA3A VWA3B DSPP SMOC2 LRG1 SMOC1 COMP EFEMP2 EFEMP1 BMPER DMBT1 IBSP TNN TNR SVEP1 TECTA TECTB POSTN IGFBP5 ADIPOQ IGFBP2 PCOLCE VWDE IGFALS EMID1 FBLN7 FBN2 FBN3 LTBP4 DPT FBLN1 LTBP2 AEBP1 LTBP3 FBLN2 LTBP1 FBLN5 VTN IGFBP7 IGFBP6 AMELX AMELY AMBN CRIM1 PXDNL OTOL1 IGSF10 TGFBI FBN1 SNED1 TNFAIP6 WISP3 CYR61 WISP1 WISP2 EMILIN3 EMILIN2 EMILIN1 OIT3 EDIL3 FGB FGA VWF FGG MEPE ELSPBP1 MMRN1 MMRN2 ZP1 ZP3 ZP2 ZP4 PCOLCE2 SSPO FGL1 FGL2 NDNF THBS2 COCH POMZP3 THBS4 THSD4 THBS3 IGFBPL1 SLIT1 SLIT3 ZPLD1 LAMA5 LGI1 LGI4 LAMA2 LGI3 LAMC3 LGI2 LAMA1 TSPEAR LAMA4 NELL2 LAMA3 MFAP5 PAPLN MFAP4 NTN4 NELL1 NTN5 FRAS1 LAMC2 MFAP1 LAMC1 MFAP3 NID1 MGP NID2 MFAP2 NTN1 KCP NTN3 HMCN1 NTNG1 NTNG2 LAMB3 LAMB2 LAMB4 LAMB1 NPNT USH2A COLQ AGRN IGFBP1 CTGF TNC THBS1 FN1 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES%MSIGDB_C2%SIG_IL4RECEPTOR_IN_B_LYPHOCYTES SIG_IL4RECEPTOR_IN_B_LYPHOCYTES SOCS1 STAT6 PIK3CA BCL2 SOS2 GRB2 PPP1R13B SOS1 GSK3B RAF1 MAP4K1 PIK3CD BAD SHC1 PIK3R1 GSK3A IRS1 MAPK1 IRS2 IL4R AKT2 AKT1 AKT3 JAK3 MAPK3 JAK1 PDK1 BIOCARTA_NGF_PATHWAY%MSIGDB_C2%BIOCARTA_NGF_PATHWAY BIOCARTA_NGF_PATHWAY MAPK8 FOS PIK3CA ELK1 NGFR HRAS CSNK2A1 NGF GRB2 PLCG1 SOS1 SHC1 PIK3R1 JUN PIK3CG RAF1 MAP2K1 MAPK3 PID_CXCR3_PATHWAY%MSIGDB_C2%PID_CXCR3_PATHWAY PID_CXCR3_PATHWAY ARRB1 CXCL11 PDPK1 GNB1 MTOR MAPK11 PIK3CA HRAS MAP2K2 ITGB2 RAF1 MAP2K6 GNAZ MAP2K3 GNAI3 GNAI1 PIK3CD PIK3R3 GNAI2 PIK3R2 PIK3CB GNG2 GNAO1 MAPKAP1 ITGAL CXCR3 SRC MLST8 RICTOR MAPK14 PIK3R1 PF4 NRAS CXCL9 MAPK1 CCL11 AKT1 DNM1 MAP2K1 MAPK3 KRAS CXCL13 CXCL10 BIOCARTA_TRKA_PATHWAY%MSIGDB_C2%BIOCARTA_TRKA_PATHWAY BIOCARTA_TRKA_PATHWAY NTRK1 PIK3CA HRAS AKT1 PRKCB GRB2 PLCG1 NGF SOS1 PRKCA SHC1 PIK3R1 ST_B_CELL_ANTIGEN_RECEPTOR%MSIGDB_C2%ST_B_CELL_ANTIGEN_RECEPTOR ST_B_CELL_ANTIGEN_RECEPTOR BTK NFKB1 PIK3CA SOS2 GRB2 PPP1R13B SOS1 TONSL MAP2K2 NFKBIL1 RAF1 NFKB2 NFKBIE PIK3CD NFKBIB BAD SERPINA4 SYK SHC1 PIK3R1 NFKBIA MAPK1 NFAT5 EPHB2 PRDX1 PI3 CD19 DAG1 BLNK AKT2 PLCG2 AKT1 AKT3 CSK MAP2K1 VAV1 ITPKB LYN BCR ITPKA PID_VEGFR1_PATHWAY%MSIGDB_C2%PID_VEGFR1_PATHWAY PID_VEGFR1_PATHWAY PTPN11 PDPK1 VEGFA PIK3CA NRP1 PLCG1 SHC2 NRP2 NOS3 CBL PGF PRKCB PRKACA PRKCA FLT1 CD2AP HIF1A PIK3R1 MAPK1 NCK1 AKT1 CAV1 MAPK3 VEGFB RASA1 HSP90AA1 BIOCARTA_VIP_PATHWAY%MSIGDB_C2%BIOCARTA_VIP_PATHWAY BIOCARTA_VIP_PATHWAY NFKB1 EGR2 PLCG1 VIPR2 EGR3 VIP NFATC2 MAP3K1 CHUK NFATC1 PPP3CA PPP3CB PPP3CC CALM3 CALM1 GNAQ CALM2 NFKBIA RELA MYC PRKAR1B PRKAR2B PRKAR1A PRKACG PRKAR2A PRKACB PID_GMCSF_PATHWAY%MSIGDB_C2%PID_GMCSF_PATHWAY PID_GMCSF_PATHWAY PTPN11 STAT1 GAB2 INPP5D PIK3CA HRAS GRB2 SOS1 STAT5A STAT5B YWHAZ CCL2 CISH MAP2K2 JAK2 CSF2RA IRF8 RAF1 PRKACA FOS PIM1 STAT3 SYK SHC1 PIK3R1 IKBKB NRAS MAPK1 CSF2 CSF2RB PRKACG MAP2K1 MAPK3 OSM KRAS LYN PRKACB BIOCARTA_BARRESTIN_PATHWAY%MSIGDB_C2%BIOCARTA_BARRESTIN_PATHWAY BIOCARTA_BARRESTIN_PATHWAY ARRB1 GNGT1 GNB1 ADCY1 PLCB1 DNM1 AP2A1 PPARA GNAS AP2M1 BIOCARTA_CARDIACEGF_PATHWAY%MSIGDB_C2%BIOCARTA_CARDIACEGF_PATHWAY BIOCARTA_CARDIACEGF_PATHWAY EDN1 FOS NFKB1 RHOA AGT HRAS PLCG1 EGF EDNRA EDNRB EGFR ADAM12 RELA MYC JUN PRKCB AGTR1 PRKCA NABA_COLLAGENS%MSIGDB_C2%NABA_COLLAGENS NABA_COLLAGENS COL1A1 COL4A2 COL4A1 COL4A4 COL6A2 COL6A1 COL4A3 COL4A6 COL6A3 COL4A5 COL6A6 COL6A5 COL16A1 COL13A1 COL14A1 COL11A1 COL12A1 COL11A2 COL3A1 COL19A1 COL1A2 COL10A1 COL28A1 COL26A1 COL27A1 COL24A1 COL25A1 COL22A1 COL23A1 COL2A1 COL5A1 COL5A3 COL7A1 COL5A2 COL18A1 COL9A1 COL20A1 COL15A1 COL8A2 COL21A1 COL8A1 COL9A3 COL9A2 COL17A1 PID_WNT_NONCANONICAL_PATHWAY%MSIGDB_C2%PID_WNT_NONCANONICAL_PATHWAY PID_WNT_NONCANONICAL_PATHWAY YES1 RHOA CAMK2A CSNK1A1 CHD7 NLK DVL1 DVL2 DVL3 FLNA NFATC2 SETDB1 CTHRC1 DAAM1 PPARG MAPK8 FZD2 MAPK9 FZD5 TAB2 WNT5A FZD6 TAB1 FZD7 ROCK1 MAPK10 ROR2 PRKCZ CDC42 ARRB2 RAC1 MAP3K7 BIOCARTA_IL12_PATHWAY%MSIGDB_C2%BIOCARTA_IL12_PATHWAY BIOCARTA_IL12_PATHWAY MAPK8 STAT4 TYK2 IL12RB1 CD3G CCR5 CD3E CXCR3 IL18R1 CD3D IFNG IL12RB2 MAPK14 CD247 JAK2 IL12B IL12A IL18 JUN MAP2K6 ETV5 BIOCARTA_P27_PATHWAY%MSIGDB_C2%BIOCARTA_P27_PATHWAY BIOCARTA_P27_PATHWAY TFDP1 RB1 CCNE1 CDKN1B CDK2 CUL1 NEDD8 CKS1B SKP1 UBE2M RBX1 E2F1 SKP2 ST_WNT_CA2_CYCLIC_GMP_PATHWAY%MSIGDB_C2%ST_WNT_CA2_CYCLIC_GMP_PATHWAY ST_WNT_CA2_CYCLIC_GMP_PATHWAY ITPR3 PDE6D PDE6C PDE6B PDE6A CFB CAMK2D CAMK2A CAMK2G NFAT5 DAG1 CAMK2B PDE6H TF PDE6G ITPR1 ITPKB SLC6A13 ITPR2 ITPKA BIOCARTA_RELA_PATHWAY%MSIGDB_C2%BIOCARTA_RELA_PATHWAY BIOCARTA_RELA_PATHWAY TNF TNFRSF1A NFKB1 TRAF6 IKBKB NFKBIA HDAC3 EP300 RELA TRADD FADD RIPK1 IKBKG TNFRSF1B CREBBP CHUK PID_ARF6_PATHWAY%MSIGDB_C2%PID_ARF6_PATHWAY PID_ARF6_PATHWAY ARRB1 ARF6 ADRB2 GIT1 EGF TSHR ITGA2B CYTH2 KIF13B FBXO8 LHCGR USP6 IQSEC1 ARAP2 ADAP1 IPCEF1 GULP1 EFNA1 GNA14 ACAP2 GNA15 HGF GNA11 MET GNAQ PXN EPHA2 SRC ITGB3 EGFR CYTH3 ACAP1 NCK1 ARRB2 AGTR1 PID_RXR_VDR_PATHWAY%MSIGDB_C2%PID_RXR_VDR_PATHWAY PID_RXR_VDR_PATHWAY TNF RXRB RXRA RPS6KB1 RXRG BCL2 SREBF1 TGFB1 PPARA NCOA1 PPARG MED1 RARG THRB THRA FAM120B ABCA1 NR1H2 NR1H4 NR1H3 NCOR2 NR4A1 RARA RARB PPARD VDR PID_NFKAPPAB_CANONICAL_PATHWAY%MSIGDB_C2%PID_NFKAPPAB_CANONICAL_PATHWAY PID_NFKAPPAB_CANONICAL_PATHWAY TNF TNFRSF1A NFKB1 CYLD RIPK2 UBE2D3 TRAF6 BCL10 SSPO NOD2 ATM MALT1 ERC1 IKBKB TNFAIP3 NFKBIA RELA XPO1 RAN IKBKG PRKCA BIRC2 CHUK PID_IL1_PATHWAY%MSIGDB_C2%PID_IL1_PATHWAY PID_IL1_PATHWAY MAP3K3 NFKB1 SQSTM1 PIK3CA TRAF6 ERC1 IL1A IL1RAP IRAK1 TICAM2 CASP1 IL1R1 IL1R2 IKBKG IRAK3 MAP2K6 IRAK4 TOLLIP IL1B UBE2N UBE2V1 MYD88 CHUK MAPK8 PRKCI IL1RN TAB2 TAB1 PIK3R1 IKBKB PRKCZ RELA JUN MAP3K7 BIOCARTA_GCR_PATHWAY%MSIGDB_C2%BIOCARTA_GCR_PATHWAY BIOCARTA_GCR_PATHWAY GNGT1 NFKB1 GNB1 PIK3CA CALM3 CALM1 ADRB2 CALM2 NPPA CORIN NOS3 PIK3R1 ANXA1 RELA NR3C1 PIK3CG AKT1 GNAS HSP90AA1 PID_RHOA_REG_PATHWAY%MSIGDB_C2%PID_RHOA_REG_PATHWAY PID_RHOA_REG_PATHWAY FARP1 ARHGEF10 ARHGEF12 ARHGEF15 RHOA ARHGEF17 MCF2 PLEKHG6 CDKN1B ARHGEF18 ARAP3 MYO9B ARAP1 DEF6 NET1 OBSCN DLC1 ARHGEF3 ARHGEF5 NGEF ARHGDIB ARHGEF1 ARHGEF2 ARHGAP9 TRIO ARHGAP8 ARHGEF25 ARHGEF28 ARHGDIG ARHGEF10L ARHGAP5 ARHGAP6 ARHGAP35 ARHGAP4 ABR AKAP13 OPHN1 MCF2L ECT2 VAV1 SRGAP1 ARHGDIA ARHGEF11 BCR VAV3 VAV2 BIOCARTA_CFTR_PATHWAY%MSIGDB_C2%BIOCARTA_CFTR_PATHWAY BIOCARTA_CFTR_PATHWAY SLC9A3R1 ADCY1 PRKAR1B CFTR PRKAR2B ADRB2 PRKAR1A PRKACG EZR PRKAR2A GNAS PRKACB PID_LIS1_PATHWAY%MSIGDB_C2%PID_LIS1_PATHWAY PID_LIS1_PATHWAY PAFAH1B3 PAFAH1B2 CDK5R2 RHOA NDEL1 LRPAP1 ABL1 VLDLR LRP8 RELN DAB1 CDK5 MAP1B CDK5R1 PAFAH1B1 CSNK2A1 IQGAP1 CDC42 PPP2R5D YWHAE PLA2G7 KATNA1 RAC1 DYNC1H1 NUDC DYNLT1 CLIP1 DCX BIOCARTA_RACCYCD_PATHWAY%MSIGDB_C2%BIOCARTA_RACCYCD_PATHWAY BIOCARTA_RACCYCD_PATHWAY CDK6 NFKB1 RHOA RB1 CDKN1A PIK3CA CDKN1B CDK2 HRAS CDK4 IKBKG RAF1 CHUK TFDP1 CCNE1 PIK3R1 IKBKB PAK1 NFKBIA RELA MAPK1 CCND1 E2F1 AKT1 RAC1 MAPK3 PID_AVB3_OPN_PATHWAY%MSIGDB_C2%PID_AVB3_OPN_PATHWAY PID_AVB3_OPN_PATHWAY NFKB1 RHOA PIK3CA ROCK2 ILK PIP5K1A PLAU CD44 MAP3K1 CHUK MMP2 MAPK8 FOS MAP3K14 PTK2B BCAR1 SYK MMP9 ITGB3 PIK3R1 NFKBIA RELA SPP1 MAPK1 GSN CDC42 JUN ITGAV RAC1 MAPK3 VAV3 PID_ECADHERIN_KERATINOCYTE_PATHWAY%MSIGDB_C2%PID_ECADHERIN_KERATINOCYTE_PATHWAY PID_ECADHERIN_KERATINOCYTE_PATHWAY FYN RHOA CTNNB1 PIK3CA VASP CTNND1 PLCG1 SRC PIK3R1 PIP5K1A EGFR AJUBA CASR JUP FMN1 ZYX CDH1 AKT2 CTNNA1 AKT1 RAC1 PID_DELTA_NP63_PATHWAY%MSIGDB_C2%PID_DELTA_NP63_PATHWAY PID_DELTA_NP63_PATHWAY CDKN2A BRCA2 MDM2 YAP1 HES1 ATM HBP1 IL1A BDKRB2 GSK3B TOP2A NOTCH1 MRE11A WWP1 STXBP4 RRAD TP63 DLX5 FBXW7 DLX6 ITCH SEC14L2 T IGFBP3 PPP2R5A HELLS TCF7L1 GPX2 ADRM1 KRT5 NRG1 POU2F2 FOSL2 RUNX1 AXL FASN KRT14 RAB38 ADA ITGA3 COL5A1 PERP SFN CEBPD CCNB2 GNB2L1 VDR BIOCARTA_NKT_PATHWAY%MSIGDB_C2%BIOCARTA_NKT_PATHWAY BIOCARTA_NKT_PATHWAY IL2 CCR7 CCR4 CCR3 CCR2 CCR1 IFNGR1 IFNGR2 CD40LG CCL4 IFNG CCL3 TGFB2 TGFB1 IL4 TGFB3 CXCR4 IL5 IL12RB1 CCR5 CXCR3 IL18R1 IL12RB2 CD4 CD28 IL12B IL12A CSF2 IL4R PID_IFNG_PATHWAY%MSIGDB_C2%PID_IFNG_PATHWAY PID_IFNG_PATHWAY PTPN11 RAPGEF1 STAT1 SOCS1 MTOR PIK3CA CRKL IFNGR1 CAMK2A IFNG EP300 JAK2 PIAS4 PIAS1 DAPK1 CBL PTGES2 CASP1 IRF1 PTPN2 IRF9 IL1B MAP3K1 SMAD7 MAP3K11 STAT3 PRKCD CAMK2D PIK3R1 CEBPB CAMK2G MAPK1 RAP1B RAP1A AKT1 CAMK2B CREBBP MAP2K1 MAPK3 JAK1 PID_INTEGRIN2_PATHWAY%MSIGDB_C2%PID_INTEGRIN2_PATHWAY PID_INTEGRIN2_PATHWAY JAM3 THY1 PLAUR CD40LG TGFBI PLAU ITGB2 CYR61 PLAT F10 FGB FGA ICAM2 FGG ICAM3 ICAM4 C3 ITGAX GP1BA PROC FCGR2A VCAM1 ITGAD SPON2 ITGAM ITGAL ICAM1 KNG1 F11R BIOCARTA_P53_PATHWAY%MSIGDB_C2%BIOCARTA_P53_PATHWAY BIOCARTA_P53_PATHWAY TIMP3 RB1 CCNE1 CDKN1A PCNA CDK2 MDM2 BAX TP53 BCL2 ATM CDK4 APAF1 CCND1 GADD45A E2F1 BIOCARTA_IL4_PATHWAY%MSIGDB_C2%BIOCARTA_IL4_PATHWAY BIOCARTA_IL4_PATHWAY IL2RG IRS1 RPS6KB1 STAT6 IL4R IL4 AKT1 GRB2 JAK3 JAK1 SHC1 ST_G_ALPHA_I_PATHWAY%MSIGDB_C2%ST_G_ALPHA_I_PATHWAY ST_G_ALPHA_I_PATHWAY ITPR3 CFB SOS2 BRAF GRB2 SOS1 PLCB3 PLCB1 RAF1 PLCB2 PIK3CB STAT3 SRC SHC1 ASAH1 EGFR RGS20 DRD2 MAPK1 PITX2 EPHB2 KCNJ3 PI3 KCNJ5 KCNJ9 DAG1 PLCB4 TERF2IP AKT2 AKT1 AKT3 ITPR1 ITPKB ITPR2 ITPKA BIOCARTA_RANKL_PATHWAY%MSIGDB_C2%BIOCARTA_RANKL_PATHWAY BIOCARTA_RANKL_PATHWAY MAPK8 FOS NFKB1 IFNAR2 EIF2AK2 TNFRSF11A IFNAR1 TRAF6 FOSL2 TNFSF11 RELA IRF9 IFNB1 FOSL1 BIOCARTA_FEEDER_PATHWAY%MSIGDB_C2%BIOCARTA_FEEDER_PATHWAY BIOCARTA_FEEDER_PATHWAY LCT KHK HK1 TPI1 TREH PGM1 MPI PYGM PYGL ST_GA13_PATHWAY%MSIGDB_C2%ST_GA13_PATHWAY ST_GA13_PATHWAY NFKB1 CFB SRF PLD1 BCL2 PLD2 ROCK2 TONSL IKBKG NFKBIL1 PLD3 RDX MAP2K4 PHKA2 NFKB2 PRKD1 NFKBIE MAP3K1 NFKBIB PIK3CB MAPK8 GNA13 TBXA2R ROCK1 SERPINA4 PTK2 NFKBIA CDC42 PI3 LPA AKT2 AKT1 AKT3 MAP3K5 PDK1 ARHGEF11 DLG4 BIOCARTA_DC_PATHWAY%MSIGDB_C2%BIOCARTA_DC_PATHWAY BIOCARTA_DC_PATHWAY CD40 CD5 IL5 ANPEP ITGAX CD7 TLR9 TLR7 TLR4 CD33 TLR2 IFNG IFNA1 CD2 IL10 IL12B IL12A CSF2 IL13 IFNB1 IL4 IL3 ST_FAS_SIGNALING_PATHWAY%MSIGDB_C2%ST_FAS_SIGNALING_PATHWAY ST_FAS_SIGNALING_PATHWAY DAXX PTPN13 NR0B2 NFKB1 CDK2AP1 BAX FAS XIAP TPX2 TONSL IL1A CASP8 CASP3 CSNK1A1 FADD AGFG1 RALBP1 RIPK1 NFKBIL1 MAP2K4 EZR NFKB2 NFKBIE MAP3K1 NFKBIB TRAF2 MAPK9 CAD ROCK1 MAPK10 TP53 NFKBIA CXCL8 MAPK1 EPHB2 MAPK8IP3 BTK CASP10 DFFA PARP1 MAP2K7 MAPK8IP1 DIABLO MAPK8 CD7 MET EGFR TNFRSF6B FAF1 FAIM2 NFAT5 SMPD1 NCS1 ALG2 BAK1 MAPK8IP2 HSPB1 TUFM PFN1 PFN2 DEDD2 MAP3K5 DEDD CASP8AP2 BFAR PID_CONE_PATHWAY%MSIGDB_C2%PID_CONE_PATHWAY PID_CONE_PATHWAY RDH5 CNGB3 PDE6C GNB3 CNGA3 LRAT RGS9 GNB5 SLC24A2 GUCY2D GUCA1B GUCA1A GUCA1C GUCY2F RPE65 PDE6H ARR3 GNGT2 RDH12 GNAT2 RGS9BP GRK7 BIOCARTA_WNT_PATHWAY%MSIGDB_C2%BIOCARTA_WNT_PATHWAY BIOCARTA_WNT_PATHWAY AXIN1 WNT1 APC PPP2CA CSNK1A1 CSNK1D GSK3B SMAD4 NLK DVL1 FZD1 CTNNB1 TAB1 HDAC1 CSNK2A1 WIF1 CCND1 MYC CTBP1 PPARD LEF1 FRAT1 CREBBP BTRC MAP3K7 TLE1 SA_G1_AND_S_PHASES%MSIGDB_C2%SA_G1_AND_S_PHASES SA_G1_AND_S_PHASES CDKN2A ARF3 ARF1 NXT1 CDKN1A PRB1 CDKN1B CDK2 MDM2 TP53 E2F2 CDK4 CCND1 E2F1 CFL1 PID_THROMBIN_PAR1_PATHWAY%MSIGDB_C2%PID_THROMBIN_PAR1_PATHWAY PID_THROMBIN_PAR1_PATHWAY ARRB1 GNB1 RHOA PIK3CA VASP ROCK2 SNX1 SNX2 PRKCG NOS3 F2R PKN1 TRPC6 PLCB3 ZYX PLCB1 PLCB2 GNAZ GNAI3 PRKCB GNAI1 PRKCA GNAI2 ARHGEF1 GNA14 GNA13 GNA15 GNA11 GNG2 GNA12 ADRBK2 GNAO1 F2RL2 ROCK1 PRKCD GNAQ F2 DNM2 PIK3R1 AKAP13 MYL2 DNM1 ARHGDIA BIOCARTA_ASBCELL_PATHWAY%MSIGDB_C2%BIOCARTA_ASBCELL_PATHWAY BIOCARTA_ASBCELL_PATHWAY IL10 CD40 CD28 IL2 CD80 HLA-DRA HLA-DRB1 FAS IL4 CD40LG FASLG CD4 ST_ADRENERGIC%MSIGDB_C2%ST_ADRENERGIC ST_ADRENERGIC ITPR3 APC CFB PIK3CA BRAF CCL16 CCL15 RAF1 PHKA2 GNAI1 PIK3CD GNA15 GNA11 GAST CAMP MAPK10 GNAQ AR PTX3 SRC MAPK14 PIK3R1 ASAH1 EGFR CCL13 MAPK1 PITX2 KCNJ3 KCNJ5 KCNJ9 DAG1 AKT1 ITPR1 ITPKB ITPR2 ITPKA PID_MET_PATHWAY%MSIGDB_C2%PID_MET_PATHWAY PID_MET_PATHWAY PTPN11 PDPK1 GAB2 RHOA MTOR APC PIK3CA PAK4 HRAS GRB2 SOS1 RAB5A PARD6A PTPN2 GAB1 MAP2K4 MAP3K1 PRKCI HGF BAD CTNNB1 F2RL2 PXN WASL MUC20 SRC PAK1 MAPK1 CDC42 RAP1B RAP1A EIF4E JUN CDH1 NCK1 AKT2 CTNNA1 RAPGEF1 SNAI1 CRK INPP5D ARF6 CRKL PLCG1 MAP2K2 INPPL1 CBL ETS1 RAF1 NCK2 PAK2 MAPK8 MET BCAR1 MLST8 PTK2 SHC1 SH3KBP1 PIK3R1 PTPRJ RPTOR DEPTOR PRKCZ SH3GL2 PTPN1 HGS AKT1S1 NUMB ARHGEF4 RIN2 KPNB1 AKT1 EIF4EBP1 RAC1 MAP2K1 EPS15 MAPK3 EGR1 RANBP9 RANBP10 PID_PI3KCI_AKT_PATHWAY%MSIGDB_C2%PID_PI3KCI_AKT_PATHWAY PID_PI3KCI_AKT_PATHWAY YWHAB PDPK1 MTOR YWHAQ CDKN1A CDKN1B YWHAG YWHAH FOXO1 YWHAZ BCL2L1 KPNA1 TBC1D4 CASP9 GSK3B RAF1 PRKACA CHUK PRKDC BAD MAPKAP1 SRC SLC2A4 MLST8 RICTOR GSK3A FOXO3 SFN YWHAE AKT2 AKT1 AKT3 FOXO4 MAP3K5 HSP90AA1 SA_PTEN_PATHWAY%MSIGDB_C2%SA_PTEN_PATHWAY SA_PTEN_PATHWAY PTK2B PIK3CA GRB2 SOS1 PTEN SHC1 ILK BPNT1 MAPK1 AKT2 AKT1 AKT3 IPCEF1 MAPK3 PIK3CD RBL2 PDK1 BIOCARTA_EGF_PATHWAY%MSIGDB_C2%BIOCARTA_EGF_PATHWAY BIOCARTA_EGF_PATHWAY STAT1 STAT6 PIK3CA SRF ELK1 HRAS PLCG1 GRB2 EGF SOS1 STAT5A STAT5B RAF1 MAP2K4 PRKCB MAP3K1 PRKCA MAPK8 FOS STAT3 STAT4 STAT2 CSNK2A1 SHC1 PIK3R1 EGFR JUN MAP2K1 MAPK3 RASA1 JAK1 PID_AR_NONGENOMIC_PATHWAY%MSIGDB_C2%PID_AR_NONGENOMIC_PATHWAY PID_AR_NONGENOMIC_PATHWAY GNB1 PIK3CA HRAS PLCG1 MAP2K2 PELP1 PLCB3 GNRH1 PLCB1 SHBG RAF1 PLCB2 GNAZ GNAI3 GNAI1 CREB1 GNAI2 FOS GNG2 GNAO1 AR SRC PTK2 PIK3R1 MAPK1 CDC42 PLCG2 AKT1 RAC1 MAP2K1 MAPK3 PID_AR_TF_PATHWAY%MSIGDB_C2%PID_AR_TF_PATHWAY PID_AR_TF_PATHWAY RXRB RXRA CARM1 RXRG EP300 NR2C2 SIRT1 MAP2K6 EHMT2 MAP2K4 ZMIZ2 TRIM24 KAT7 SMARCC1 KAT2B SENP1 PDE9A TMPRSS2 KLK3 KLK2 HOXB13 NR2C1 SRY SPDEF SMARCE1 CEBPA POU2F1 HDAC1 NR0B1 DNAJA1 SRC APPBP2 MAPK14 REL GNB2L1 JUN CREBBP SMARCA2 MDM2 FOXO1 PKN1 GSK3B KAT5 NCOA1 NCOA2 MAPK8 AR GATA2 HDAC7 RCHY1 NR3C1 EGR1 HSP90AA1 PID_THROMBIN_PAR4_PATHWAY%MSIGDB_C2%PID_THROMBIN_PAR4_PATHWAY PID_THROMBIN_PAR4_PATHWAY GNA13 GNA15 F2RL3 GNA11 GNB1 RHOA GNG2 F2RL2 ROCK1 GNAQ F2 ROCK2 MYL2 PLCB2 GNA14 BIOCARTA_MTA3_PATHWAY%MSIGDB_C2%BIOCARTA_MTA3_PATHWAY BIOCARTA_MTA3_PATHWAY SNAI1 MBD3 PDZK1 TUBA4A TUBA1C ALDOA TUBA3C TUBA1A SNAI2 MTA3 HDAC1 GAPDH MTA1 HSPB2 CTSD HSPB1 CDH1 ESR1 NABA_ECM_AFFILIATED%MSIGDB_C2%NABA_ECM_AFFILIATED NABA_ECM_AFFILIATED C1QTNF5 SEMA3A ANXA6 SEMA3B ANXA7 ITLN1 SEMA3G ANXA8 ITLN2 ANXA9 SEMA3E SEMA3F CLEC3A CLEC3B MUC16 MUC17 CLEC17A ANXA1 SEMA4A ANXA2 ANXA3 ANXA4 SEMA4D ANXA5 SEMA4B SEMA4C SEMA4F SEMA4G CLEC2A CLEC2B SFTPA1 CLEC2D LGALSL LGALS4 LGALS3 LGALS2 MUC20 LGALS1 MUC21 MUC22 LGALS9 LGALS8 LGALS7 MUCL1 LMAN1L CLEC14A GRIFIN LMAN1 SDC2 GREM1 SDC3 REG4 COLEC12 COLEC11 COLEC10 CLEC12A CLEC12B MUC1 MUC7 MUC4 MUC6 MUC5B CD209 SDC1 PLXDC2 PLXDC1 CLC SEMA5A SEMA5B CLEC4M PLXND1 CLEC9A REG1B MUC12 CLEC5A MUC13 PLXNC1 SEMA6B MUC15 SEMA6C SEMA6A REG1A SFTPB SEMA6D SFTPC SFTPD CLEC4A CLEC4C CLEC4D CLEC10A C1QB CLEC4E C1QA CLEC4F CLEC4G CLEC11A REG3A LGALS14 SEMA7A LGALS16 PARM1 LGALS13 REG3G LGALS12 GPC1 FREM1 CLEC7A GPC3 FREM2 GPC2 FREM3 PLXNA2 GPC5 PROL1 PLXNA1 GPC4 GPC6 PLXNA4 PLXNA3 HPX CLEC6A PLXNB3 CSPG5 PLXNB2 PLXNB1 CSPG4 C1QC FCN1 FCN2 ELFN2 FCN3 ELFN1 CLEC18C CLEC18B CLEC1A CLEC18A SDC4 CLEC1B SFTA2 SFTA3 ANXA8L1 MBL2 ANXA13 C1QTNF9 OVGP1 ANXA11 ANXA10 C1QL4 MUC3A LGALS9C C1QL3 LGALS9B C1QL2 C1QTNF4 MUC5AC C1QTNF3 C1QL1 EMCN C1QTNF2 C1QTNF1 C1QTNF8 C1QTNF7 SFTPA2 C1QTNF6 SEMA3C CLEC2L SEMA3D BIOCARTA_MONOCYTE_PATHWAY%MSIGDB_C2%BIOCARTA_MONOCYTE_PATHWAY BIOCARTA_MONOCYTE_PATHWAY PECAM1 CD44 ITGB2 SELE ITGB1 ITGAM ITGAL SELP ICAM1 SELL ITGA4 BIOCARTA_INTEGRIN_PATHWAY%MSIGDB_C2%BIOCARTA_INTEGRIN_PATHWAY BIOCARTA_INTEGRIN_PATHWAY RAPGEF1 FYN TLN1 RHOA CRKL HRAS GRB2 SOS1 MAP2K2 TNS1 PPP1R12B VCL CAPN1 ZYX RAF1 ITGB1 ACTN3 ACTN2 MAPK8 CAPNS1 CAPNS2 ACTN1 ROCK1 PXN BCAR1 SRC PTK2 SHC1 ITGA1 MAPK1 RAP1A JUN CSK MAP2K1 CAV1 MAPK3 BCR ACTA1 BIOCARTA_ARENRF2_PATHWAY%MSIGDB_C2%BIOCARTA_ARENRF2_PATHWAY BIOCARTA_ARENRF2_PATHWAY MAPK8 FOS MAPK14 MAPK1 JUN KEAP1 FXYD2 MAFG PRKCB MAFF CREB1 MAFK PRKCA SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES%MSIGDB_C2%SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES ITPR3 CDKN2A BTK NR0B2 RPS6KB1 PIK3CA PPP1R13B PTEN PREX1 GAB1 PIK3R5 FLOT1 FLOT2 PHF11 SAG RPS6KA1 SYK PTPRC FOXO3 PITX2 DAPP1 CYTH3 CD19 RPS6KA3 RPS6KA2 AKT2 PLCG2 AKT1 AKT3 VAV1 ITPR1 PDK1 LYN BCR ITPR2 NR4A3 BIOCARTA_CSK_PATHWAY%MSIGDB_C2%BIOCARTA_CSK_PATHWAY BIOCARTA_CSK_PATHWAY GNGT1 GNB1 LCK ZAP70 CD3G CD3E CD3D CD4 PTPRC CD247 ADCY1 HLA-DRA PRKAR1B HLA-DRB1 PRKAR2B PRKAR1A CREBBP PRKACG CSK PRKAR2A GNAS PRKACB BIOCARTA_PAR1_PATHWAY%MSIGDB_C2%BIOCARTA_PAR1_PATHWAY BIOCARTA_PAR1_PATHWAY GNGT1 ARHGEF10 F2RL3 ARHGEF12 GNB1 ARHGEF15 RHOA ARHGEF17 ARHGEF7 ARHGEF6 PIK3CA ARHGEF18 F2R ARHGEF3 ARHGEF5 PPP1R12B ADCY1 PLCB1 PIK3CG PRKCB GNAI1 PRKCA ARHGEF1 ARHGEF2 GNA13 GNA12 PTK2B ROCK1 GNAQ F2 ARHGEF16 ARHGEF19 ARHGEF9 PIK3R1 ARHGEF4 MAP3K7 ARHGEF11 SA_MMP_CYTOKINE_CONNECTION%MSIGDB_C2%SA_MMP_CYTOKINE_CONNECTION SA_MMP_CYTOKINE_CONNECTION ACE TNF TNFRSF1A IL6R SELL CD44 SPN FCGR3A TNFRSF8 TGFB2 TGFB1 TNFSF8 CSF1 TNFRSF1B IL1B PID_ATM_PATHWAY%MSIGDB_C2%PID_ATM_PATHWAY PID_ATM_PATHWAY TERF2 YWHAB FAM175A BLM RFWD2 MDM2 BRCA1 ATM NBN TRIM28 ABL1 KAT5 TOP3A H2AFX CDC25A UBE2N MRE11A CDC25C RAD50 FANCD2 CHEK2 RAD17 RAD9A RBBP8 MDC1 BID DCLRE1C CTBP1 RNF8 SMC3 UIMC1 TP53BP1 XRCC4 SMC1A ST_GRANULE_CELL_SURVIVAL_PATHWAY%MSIGDB_C2%ST_GRANULE_CELL_SURVIVAL_PATHWAY ST_GRANULE_CELL_SURVIVAL_PATHWAY APC CXCR2 CERK CASP3 CREB3 MAP2K7 PARP1 CREB5 MAP2K4 MAPK8IP1 CREB1 MAPK8 MAPK9 FOS CAMP MAPK10 GNAQ ASAH1 MAPK1 EPHB2 MAPK8IP3 DAG1 JUN MAPK8IP2 ITPKB CXCL2 ITPKA BIOCARTA_ETS_PATHWAY%MSIGDB_C2%BIOCARTA_ETS_PATHWAY BIOCARTA_ETS_PATHWAY RBL1 FOS HDAC2 HRAS HDAC5 CSF1R DDX20 ETV3 ETS2 SIN3B SIN3A E2F4 NCOR2 ETS1 JUN CSF1 E2F1 RBL2 BIOCARTA_CTLA4_PATHWAY%MSIGDB_C2%BIOCARTA_CTLA4_PATHWAY BIOCARTA_CTLA4_PATHWAY PTPN11 ICOSLG IL2 PIK3CA LCK CD3G GRB2 CD3E CD3D PIK3R1 CD28 CD247 CD80 HLA-DRA HLA-DRB1 CD86 ITK CTLA4 ICOS PID_INSULIN_GLUCOSE_PATHWAY%MSIGDB_C2%PID_INSULIN_GLUCOSE_PATHWAY PID_INSULIN_GLUCOSE_PATHWAY YWHAB YWHAQ YWHAG YWHAH INS YWHAZ TBC1D4 GSK3B STXBP4 PRKCI ASIP PPP1R3A GYS1 STX4 INSR LNPEP PPP1CC TRIP10 SLC2A4 VAMP2 RHOQ PRKCZ SFN YWHAE AKT2 AKT1 PID_SMAD2_3PATHWAY%MSIGDB_C2%PID_SMAD2_3PATHWAY PID_SMAD2_3PATHWAY TGFBRAP1 PIAS4 SMAD2 MAPK1 SMAD4 NUP214 SMAD3 UBE2I KPNB1 CTDSPL NUP153 PPM1A MAPK3 MAP3K1 CTDSP1 CTDSP2 KPNA2 BIOCARTA_ALK_PATHWAY%MSIGDB_C2%BIOCARTA_ALK_PATHWAY BIOCARTA_ALK_PATHWAY MEF2C AXIN1 WNT1 TGFBR1 APC TGFBR2 TGFBR3 BMPR2 GATA4 HNF1A NPPB NKX2-5 BMP10 ACVR1 SMAD1 RFC1 NOG SMAD6 SMAD5 BMPR1A BMP7 TGFB2 GSK3B SMAD4 BMP5 TGFB1 DVL1 BMP4 TGFB3 FZD1 BMP2 CTNNB1 NPPA CHRD ATF2 MYL2 MAP3K7 BIOCARTA_HDAC_PATHWAY%MSIGDB_C2%BIOCARTA_HDAC_PATHWAY BIOCARTA_HDAC_PATHWAY MEF2C PIK3CA IGF1R YWHAH INS HDAC5 PIK3CG MAP2K6 IGF1 NFATC2 MAPK7 NFATC1 CABIN1 MYOD1 PPP3CA CAMK1 PPP3CB CAMK1G PPP3CC CALM3 CALM1 CALM2 MEF2D INSR MAPK14 PIK3R1 MEF2BNB-MEF2B AKT1 MEF2A BIOCARTA_PML_PATHWAY%MSIGDB_C2%BIOCARTA_PML_PATHWAY BIOCARTA_PML_PATHWAY DAXX TNF TNFRSF1A PML RB1 SP100 PAX3 PRAM1 SUMO1 FAS TP53 HRAS FASLG RARA SIRT1 TNFRSF1B CREBBP PID_ALK2_PATHWAY%MSIGDB_C2%PID_ALK2_PATHWAY PID_ALK2_PATHWAY SMAD9 SMAD5 BMP7 SMAD4 BMPR2 ACVR1 SMAD1 AMH AMHR2 FKBP1A TLX2 BIOCARTA_EIF4_PATHWAY%MSIGDB_C2%BIOCARTA_EIF4_PATHWAY BIOCARTA_EIF4_PATHWAY EIF4A1 PDPK1 MTOR RPS6KB1 EIF4G1 PIK3CA PTEN MAPK14 PIK3R1 EIF4A2 IRS1 MAPK1 PABPC1 EIF4G3 EIF4G2 EIF4E PDK2 EIF4EBP1 AKT1 PRKCB MKNK1 MAPK3 PRKCA GHR PID_PI3KCI_PATHWAY%MSIGDB_C2%PID_PI3KCI_PATHWAY PID_PI3KCI_PATHWAY CYTH1 PDPK1 PLEKHA1 PLEKHA2 RHOA LAT PIK3CA LCK ARAP3 HRAS CYTH2 PIK3CG ADAP1 ITK PIK3CD PIK3R3 PIK3R2 PIK3CB SYK SRC NRAS DAPP1 CYTH3 RAP1A BLK KRAS LYN BTK FYN YES1 ARF1 INPP5D FGR ARF6 HCK PLCG1 PTEN INPPL1 PIK3R6 PIK3R5 ZAP70 PIK3R1 FOXO3 BLNK PLCG2 RAC1 HSP90AA1 SGK1 ARF5 BIOCARTA_KREB_PATHWAY%MSIGDB_C2%BIOCARTA_KREB_PATHWAY BIOCARTA_KREB_PATHWAY SUCLA2 MDH1 IDH2 OGDH ACO2 SDHA CS FH PID_TAP63_PATHWAY%MSIGDB_C2%PID_TAP63_PATHWAY PID_TAP63_PATHWAY ITGB4 PML YWHAQ CDKN1A BAX FAS EP300 WWP1 FDXR OGG1 TP63 CHUK NOC2L S100A2 DST ITCH AEN IGFBP3 DICER1 TRAF4 SPATA18 SMARCD3 EVPL CLCA2 NQO1 TFAP2C SSPO JAG1 CABLES1 SSRP1 DHRS3 IKBKB ITGA3 PMAIP1 GADD45A VDR CDKN2A TP53I3 EGR2 SP1 MDM2 HBP1 BBC3 MFGE8 ABL1 SERPINB5 FLOT2 PLK1 GPX2 PRKCD ADA SHH PERP GDF15 PID_PLK1_PATHWAY%MSIGDB_C2%PID_PLK1_PATHWAY PID_PLK1_PATHWAY CDC14B GOLGA2 RAB1A PPP1CB CDC20 RHOA KIF20A FBXO5 RAB1B CLSPN NINL PPP2R1A CENPU FZR1 PPP1R12A BORA CDK1 ODF2 TUBG1 CENPE ROCK2 STAG2 TPX2 KIF2A PPP2CA PRC1 GORASP1 KIZ SPC24 TPT1 FBXW11 PLK1 CDC25C CDC25B WEE1 SSPO AURKA SGOL1 CCNB1 PAK1 BUB1 NDC80 INCENP ECT2 NUDC ERCC6L BUB1B SIG_CD40PATHWAYMAP%MSIGDB_C2%SIG_CD40PATHWAYMAP SIG_CD40PATHWAYMAP NFKB1 MAPKAPK5 MAPK11 PIK3CA TRAF6 TONSL GORASP1 IKBKG NFKBIL1 MAP2K7 MAP2K4 NFKB2 MAPK8IP1 NFKBIE PIK3CD DUSP1 NFKBIB MAPK8 TRAF2 CD40 MAPK9 MAPK10 SYT1 MAPK12 TRAF3 TRAF5 MAPK14 MAPK13 PIK3R1 NFKBIA MAPK1 MAPK8IP3 MAPK8IP2 MAPK3 PID_RB_1PATHWAY%MSIGDB_C2%PID_RB_1PATHWAY PID_RB_1PATHWAY MEF2C PPP2R3B TAF1 RB1 CDKN1A CDKN1B CCND3 PPP2CA EP300 HDAC3 SFTPD TGFB2 CDK4 SIRT1 CCNA2 MAPK9 TFDP1 UBTF CCNE1 CEBPA HDAC1 MAPK14 RBBP4 E2F2 SPI1 E2F3 E2F4 CCND1 JUN CTBP1 CREBBP CCND2 CDKN2A CDK6 SMARCA4 MAPK11 CDK2 MDM2 ELF1 ABL1 RAF1 SKP2 BGLAP MYOD1 PPARG MET PAX3 SMARCB1 CEBPB SUV39H1 AATF CSF2 BRD2 CEBPD TBP ATF2 MITF RUNX2 RBP2 E2F1 ATF7 DNMT1 TAF1L GSC CKM CBX4 PID_PI3K_PLC_TRK_PATHWAY%MSIGDB_C2%PID_PI3K_PLC_TRK_PATHWAY PID_PI3K_PLC_TRK_PATHWAY YWHAB PDPK1 YWHAQ PIK3CA HRAS YWHAG CAMK2A PLCG1 YWHAH GRB2 SOS1 STAT5A YWHAZ AGAP2 EPB41L1 TRPC3 TRPV1 GSK3B GAB1 CREB1 BAD PRKCD NGF SRC SHC1 PIK3R1 CAMK4 FOXO3 NRAS NTRK1 SFN YWHAE CCND1 AKT1 EGR1 KRAS BIOCARTA_PGC1A_PATHWAY%MSIGDB_C2%BIOCARTA_PGC1A_PATHWAY BIOCARTA_PGC1A_PATHWAY MEF2C PPP3CA CAMK1 PPP3CB CAMK1G PPP3CC CALM3 CALM1 CALM2 MEF2D CAMK2D CAMK2A YWHAH SLC2A4 HDAC5 CAMK4 CAMK2G ESRRA MEF2BNB-MEF2B CAMK2B PPARGC1A PPARA MEF2A BIOCARTA_CDC42RAC_PATHWAY%MSIGDB_C2%BIOCARTA_CDC42RAC_PATHWAY BIOCARTA_CDC42RAC_PATHWAY ACTR3 ACTR2 RHOA ARPC1B PDGFRA ARPC1A ARPC4 PIK3CA ARPC5 ARPC2 ARPC3 WASL PIK3R1 PAK1 CDC42 RAC1 PID_IGF1_PATHWAY%MSIGDB_C2%PID_IGF1_PATHWAY PID_IGF1_PATHWAY PTPN11 PDPK1 CRK RPS6KB1 PIK3CA CRKL HRAS IGF1R GRB2 SOS1 YWHAZ RAF1 NCK2 IGF1 PRKD1 GRB10 BAD PRKCD PXN BCAR1 PTK2 SHC1 PIK3R1 PRKCZ PTPN1 IRS1 IRS2 GNB2L1 YWHAE AKT1 BIOCARTA_CTL_PATHWAY%MSIGDB_C2%BIOCARTA_CTL_PATHWAY BIOCARTA_CTL_PATHWAY HLA-A B2M GZMB FAS CD3G ITGAL CD3E FASLG CD3D ICAM1 ITGB2 CD247 PRF1 BIOCARTA_ETC_PATHWAY%MSIGDB_C2%BIOCARTA_ETC_PATHWAY BIOCARTA_ETC_PATHWAY SLC25A4 SLC25A6 CYCS SDHA MT-CO1 GPD2 ATP5A1 NDUFA1 UQCRC1 SDHC SDHD SDHB BIOCARTA_ERK_PATHWAY%MSIGDB_C2%BIOCARTA_ERK_PATHWAY BIOCARTA_ERK_PATHWAY GNGT1 GNB1 PDGFRA ELK1 HRAS IGF1R GRB2 PTPRR SOS1 MKNK2 PPP2CA MAP2K2 RAF1 ITGB1 RPS6KA5 STAT3 NGFR RPS6KA1 NGF SRC SHC1 EGFR MAPK1 MYC MKNK1 MAP2K1 MAPK3 GNAS BIOCARTA_SARS_PATHWAY%MSIGDB_C2%BIOCARTA_SARS_PATHWAY BIOCARTA_SARS_PATHWAY LDHC LDHA FBL LDHB ANPEP GPT EIF4E NCL CKM MAPK14 PID_RETINOIC_ACID_PATHWAY%MSIGDB_C2%PID_RETINOIC_ACID_PATHWAY PID_RETINOIC_ACID_PATHWAY RXRB RXRA RXRG CDK1 PRKCG HDAC3 EP300 NRIP1 RBP1 PRKACA PRKCA NCOA1 NCOA2 KAT2B MAPK8 NCOA3 HDAC1 RARG MAPK14 CDK7 CCNH MAPK1 NCOR2 MNAT1 RARA RARB AKT1 VDR CREBBP MAPK3 BIOCARTA_CALCINEURIN_PATHWAY%MSIGDB_C2%BIOCARTA_CALCINEURIN_PATHWAY BIOCARTA_CALCINEURIN_PATHWAY PPP3CA PPP3CB PPP3CC CDKN1A NFATC4 CALM3 SP1 CALM1 GNAQ CALM2 PLCG1 NFATC3 PRKCB NFATC2 MARCKS PRKCA SP3 NFATC1 PID_AJDISS_2PATHWAY%MSIGDB_C2%PID_AJDISS_2PATHWAY PID_AJDISS_2PATHWAY FYN TIAM1 MMP7 ARF6 MMP3 HRAS IGF1R EGF SNX1 RAB5A RAB7A ABL1 CASP3 IGF2 RET ROBO1 GNA13 DSP GNA12 NTRK2 GFRA1 CTNNB1 ZBTB33 GDNF CBLL1 MET ADAM10 CTNND1 CABLES1 SRC DNM2 CDH2 IQGAP1 EGFR MEP1B SLIT1 PTPN1 HGS JUP CDC42 NME1 PTPN6 RIN2 CDH1 CTNNA1 RAC1 CREBBP BDNF PID_ECADHERIN_STABILIZATION_PATHWAY%MSIGDB_C2%PID_ECADHERIN_STABILIZATION_PATHWAY PID_ECADHERIN_STABILIZATION_PATHWAY ENAH RHOA PVRL2 ARF6 GIT1 VASP IGF1R EGF VCL ZYX IGF1 EFNA1 HGF CTNNB1 ACTN1 MET ROCK1 STX4 CTNND1 EPHA2 CYFIP2 NCKAP1 AQP5 LPP EGFR AQP3 MLLT4 LIMA1 MYO6 MGAT3 PLEKHA7 CAMSAP3 DIAPH1 CDH1 NCK1 MYL2 ABI1 CTNNA1 KIFC3 EXOC4 PIP5K1C EXOC3 BIOCARTA_TH1TH2_PATHWAY%MSIGDB_C2%BIOCARTA_TH1TH2_PATHWAY BIOCARTA_TH1TH2_PATHWAY CD40 IL2 IL2RA IFNGR1 IL12RB1 IFNGR2 CD40LG IL18R1 IFNG IL12RB2 CD28 IL12B IL12A HLA-DRA IL18 HLA-DRB1 IL4R IL4 CD86 BIOCARTA_TALL1_PATHWAY%MSIGDB_C2%BIOCARTA_TALL1_PATHWAY BIOCARTA_TALL1_PATHWAY TRAF2 MAPK8 NFKB1 MAP3K14 TNFRSF13C TRAF6 TNFRSF17 TRAF3 TRAF5 MAPK14 TNFSF13B RELA TNFSF13 TNFRSF13B CHUK BIOCARTA_CASPASE_PATHWAY%MSIGDB_C2%BIOCARTA_CASPASE_PATHWAY BIOCARTA_CASPASE_PATHWAY LMNA GZMB CYCS XIAP CASP7 LMNB2 LMNB1 CASP9 CASP6 CASP8 CASP10 CASP3 CASP4 ARHGDIB CASP1 CASP2 APAF1 DFFB DFFA PARP1 PRF1 BIRC2 BIRC3 BIOCARTA_IL1R_PATHWAY%MSIGDB_C2%BIOCARTA_IL1R_PATHWAY BIOCARTA_IL1R_PATHWAY TNF NFKB1 TRAF6 ECSIT IRAK2 IL1A IL1RAP IRAK1 TGFB2 IL1R1 TGFB1 IRAK3 MAP2K6 MAP2K3 TOLLIP TGFB3 IL1B MAP3K1 MYD88 CHUK MAPK8 IL6 MAP3K14 IL1RN TAB1 MAPK14 IFNA1 IKBKB NFKBIA RELA JUN IFNB1 MAP3K7 BIOCARTA_EDG1_PATHWAY%MSIGDB_C2%BIOCARTA_EDG1_PATHWAY BIOCARTA_EDG1_PATHWAY GNGT1 GNB1 RHOA PDGFRA PIK3CA S1PR1 SPHKAP SPHK1 ADCY1 PLCB1 PIK3CG PRKCB GNAI1 PRKCA SRC PTK2 ITGB3 PIK3R1 ASAH1 MAPK1 SMPD1 PDGFA AKT1 ITGAV RAC1 MAPK3 SMPD2 PID_TRAIL_PATHWAY%MSIGDB_C2%PID_TRAIL_PATHWAY PID_TRAIL_PATHWAY TNFRSF10A TNFRSF10D PIK3CA CASP8 CASP10 TRADD FADD DAP3 RIPK1 IKBKG CFLAR MAP2K4 PIK3CD MAP3K1 PIK3R3 CHUK PIK3R2 PIK3CB MAPK8 TRAF2 PIK3R1 IKBKB TNFSF10 MAPK1 SMPD1 MAPK3 TNFRSF10C TNFRSF10B BIOCARTA_NFKB_PATHWAY%MSIGDB_C2%BIOCARTA_NFKB_PATHWAY BIOCARTA_NFKB_PATHWAY TNF TNFRSF1A NFKB1 MAP3K14 TAB1 TLR4 TRAF6 IKBKB IL1A TNFAIP3 NFKBIA RELA TRADD IRAK1 FADD IL1R1 RIPK1 IKBKG TNFRSF1B MAP3K1 MAP3K7 MYD88 CHUK PID_CIRCADIAN_PATHWAY%MSIGDB_C2%PID_CIRCADIAN_PATHWAY PID_CIRCADIAN_PATHWAY CRY2 TIMELESS WDR5 CRY1 CLOCK CHEK1 ATR NONO CSNK1E NR1D1 NPAS2 BHLHE40 ARNTL PER2 DEC1 PER1 BIOCARTA_RARRXR_PATHWAY%MSIGDB_C2%BIOCARTA_RARRXR_PATHWAY BIOCARTA_RARRXR_PATHWAY NCOA3 RXRA HDAC3 GTF2A1 GTF2B GTF2F1 GTF2E1 NCOR2 TBP ERCC3 POLR2A RARA NCOA1 NCOA2 KAT2B BIOCARTA_RHO_PATHWAY%MSIGDB_C2%BIOCARTA_RHO_PATHWAY BIOCARTA_RHO_PATHWAY TLN1 RHOA BAIAP2 PIP5K1A ARHGEF5 PPP1R12B VCL ARHGEF1 ACTR3 LIMK1 ACTR2 ARPC1B ARPC1A ARPC4 ARPC5 ROCK1 ARPC2 MYLK ARPC3 SRC ARHGAP5 GSN ARHGAP6 ARHGAP4 DIAPH1 MYL2 OPHN1 PFN1 ARHGAP1 ARHGEF11 CFL1 PIP5K1B BIOCARTA_SPRY_PATHWAY%MSIGDB_C2%BIOCARTA_SPRY_PATHWAY BIOCARTA_SPRY_PATHWAY SPRY4 PTPRB SPRY3 SPRY2 SPRY1 HRAS GRB2 EGF SOS1 SRC SHC1 EGFR MAPK1 CBL RAF1 MAP2K1 RASA1 MAPK3 PID_S1P_S1P3_PATHWAY%MSIGDB_C2%PID_S1P_S1P3_PATHWAY PID_S1P_S1P3_PATHWAY VEGFA RHOA S1PR3 S1PR2 S1PR1 JAK2 GNAZ GNAI3 GNAI1 CXCR4 GNAI2 GNA14 GNA13 GNA15 GNA11 FLT1 GNA12 GNAO1 GNAQ SRC ITGB3 PDGFB MAPK1 AKT1 AKT3 ITGAV RAC1 MAPK3 PDGFRB BIOCARTA_GLEEVEC_PATHWAY%MSIGDB_C2%BIOCARTA_GLEEVEC_PATHWAY BIOCARTA_GLEEVEC_PATHWAY MAPK8 STAT1 FOS BAD PIK3CA CRKL HRAS GRB2 SOS1 STAT5A STAT5B PIK3R1 JAK2 MYC JUN PIK3CG RAF1 AKT1 MAP2K4 MAP2K1 MAPK3 MAP3K1 BCR BIOCARTA_CCR3_PATHWAY%MSIGDB_C2%BIOCARTA_CCR3_PATHWAY BIOCARTA_CCR3_PATHWAY GNGT1 LIMK1 GNB1 RHOA CCR3 GNAQ HRAS NOX1 ROCK2 PTK2 PIK3C2G PPP1R12B MAPK1 PLCB1 CCL11 RAF1 MYL2 MAP2K1 PRKCB MAPK3 PRKCA GNAS CFL1 BIOCARTA_MCM_PATHWAY%MSIGDB_C2%BIOCARTA_MCM_PATHWAY BIOCARTA_MCM_PATHWAY CDC6 KITLG CCNE1 MCM3 CDKN1B CDK2 ORC1 CDT1 MCM7 ORC5 ORC4 ORC6 ORC3 ORC2 MCM4 MCM5 MCM6 MCM2 BIOCARTA_CERAMIDE_PATHWAY%MSIGDB_C2%BIOCARTA_CERAMIDE_PATHWAY BIOCARTA_CERAMIDE_PATHWAY TRAF2 MAPK8 TNFRSF1A NFKB1 BAD CYCS NSMAF AIFM1 BAX BCL2 RELA CASP8 TRADD MAPK1 FADD SMPD1 RIPK1 RAF1 MAP2K4 MAP2K1 MAPK3 MAP3K1 BIOCARTA_ARAP_PATHWAY%MSIGDB_C2%BIOCARTA_ARAP_PATHWAY BIOCARTA_ARAP_PATHWAY CYTH1 ARF1 ASAP2 ARFGEF1 ARFGEF2 COPA KDELR1 GBF1 CLTB ARFGAP3 ARFGAP1 CYTH4 KDELR2 CYTH2 KDELR3 GPLD1 CYTH3 PID_HDAC_CLASSI_PATHWAY%MSIGDB_C2%PID_HDAC_CLASSI_PATHWAY PID_HDAC_CLASSI_PATHWAY TNF HDAC10 NFKB1 HDAC11 CHD4 CHD3 MBD3L2 SMG5 SIRT4 SIRT5 SIRT6 SIRT7 YY1 RANGAP1 SIRT2 WDR77 HDAC5 SAP30 SIRT3 EP300 FKBP3 HDAC3 ZFPM1 SIN3B HDAC4 RAN SIN3A HDAC8 GATA1 PRMT5 HDAC9 HDAC6 SAP18 SIRT1 RBBP7 MTA2 SMURF1 RANBP2 MBD2 PRKACA GATAD2B GATAD2A SMAD7 KAT2B TFCP2 MXD1 TNFRSF1A STAT3 NR2C1 SSPO HDAC1 RBBP4 NFKBIA NCOR2 UBE2I CREBBP MBD3 MAX PPARG NCOR1 HDAC2 SUMO1 GATA2 HDAC7 XPO1 RELA BIOCARTA_FCER1_PATHWAY%MSIGDB_C2%BIOCARTA_FCER1_PATHWAY BIOCARTA_FCER1_PATHWAY FCER1A BTK FCER1G PIK3CA ELK1 HRAS PLCG1 GRB2 SOS1 PLA2G4A PIK3CG RAF1 MAP2K7 MAP2K4 PRKCB PAK2 NFATC2 MAP3K1 NFATC1 PPP3CA MAPK8 PPP3CB PPP3CC FOS NFATC4 CALM3 CALM1 CALM2 SYK SHC1 PIK3R1 MAPK1 JUN NFATC3 MAP2K1 MAPK3 VAV1 LYN PID_TRKR_PATHWAY%MSIGDB_C2%PID_TRKR_PATHWAY PID_TRKR_PATHWAY PTPN11 GAB2 RHOA TIAM1 SQSTM1 PIK3CA HRAS ELMO1 GRB2 SOS1 SHC2 NEDD4L GAB1 DOCK1 PRKCI STAT3 NRAS MAPK1 CDC42 CCND1 RAP1B RAP1A DNM1 BDNF DYNLT1 KRAS RAPGEF1 NTF4 CRK MATK RHOG FRS2 FRS3 FAIM CRKL SHC3 NTF3 RGS19 MAGED1 PLCG1 SH2B1 NTRK3 ARHGAP32 RIT1 EHD4 RIT2 DNAJA3 ABL1 NTRK2 NGFR NGF SHC1 PIK3R1 GIPC1 PRKCZ NTRK1 MCF2L RAC1 MAP2K1 RASA1 MAPK3 RASGRF1 ST_T_CELL_SIGNAL_TRANSDUCTION%MSIGDB_C2%ST_T_CELL_SIGNAL_TRANSDUCTION ST_T_CELL_SIGNAL_TRANSDUCTION RASGRP1 PAK3 RASGRP4 RASGRP3 NFKB1 LAT LCK PAK4 SOS2 PLCG1 GRB2 SOS1 TONSL CBL NFKBIL1 RAF1 NFKB2 PAK2 NFKBIE ITK PAK7 CTLA4 PAK6 FBXW7 NFKBIB DTYMK GRAP2 LCP2 ZAP70 CD3D PAK1 NFKBIA PTPRC CD28 MAPK1 NFAT5 EPHB2 PRDX1 DAG1 NCK1 CSK VAV1 ITPKB RASGRP2 ITPKA PID_ERBB1_DOWNSTREAM_PATHWAY%MSIGDB_C2%PID_ERBB1_DOWNSTREAM_PATHWAY PID_ERBB1_DOWNSTREAM_PATHWAY MEF2C YWHAB STAT1 MTOR YWHAQ PIK3CA PPP2R1A HRAS YWHAG GRB2 YWHAH SOS1 EGF RAB5A BCL2L1 YWHAZ ATF1 GAB1 RPS6KA5 MAP2K4 CREB1 MAP3K1 F2RL2 WASL SRC IQGAP1 NRAS SFN MAPK1 CDC42 RPS6KA3 JUN KRAS VAV2 ELK1 SMAD1 PRKCA DUSP1 MAPK7 PEBP1 ACTR3 FOS ACTR2 ARPC1B CAPN2 ARPC4 ARPC5 USP6NL ARPC2 RPS6KA4 ARPC3 ZFP36 SH2D2A RALGDS MAP2K5 CYFIP2 MYLPF NCKAP1 PPP5C ARF4 BRK1 EGFR KSR1 DUSP6 CHN2 WASF2 MAP3K2 YWHAE PPP2R2A ABI1 EGR1 EPS8 PDPK1 RIN1 BRAF BAIAP2 DIAPH3 PPP2CA PIK3CD PIK3R3 PIK3R2 PIK3CB MAPK9 BAD STAT3 RALA SRF PLD1 PLD2 MAP2K2 RAF1 SLC9A1 MAPK8 PRKCD MAPKAP1 MLST8 RICTOR PIK3R1 PRKCZ ATF2 AKT1 MAP2K1 RAC1 MAPK3 RPS6 BIOCARTA_TEL_PATHWAY%MSIGDB_C2%BIOCARTA_TEL_PATHWAY BIOCARTA_TEL_PATHWAY RB1 XRCC6 TP53 XRCC5 BCL2 TNKS IGF1R TERF1 TEP1 PPP2CA EGFR TERT POLR2A MYC AKT1 PRKCA KRAS HSP90AA1 BIOCARTA_MAPK_PATHWAY%MSIGDB_C2%BIOCARTA_MAPK_PATHWAY BIOCARTA_MAPK_PATHWAY DAXX MEF2C MAP4K3 STAT1 NFKB1 MAPKAPK2 TGFBR1 RAPGEF2 MAPKAPK5 RPS6KB1 HRAS BRAF GRB2 MAPKAPK3 ARAF TRADD MAP3K8 MAP3K6 TGFB2 MAP3K4 RIPK1 MAPK6 TGFB1 MAPK4 MAP4K1 MAP2K6 RPS6KB2 MAP2K3 MAP3K10 RPS6KA5 MAP2K4 TGFB3 MAP3K13 MAP4K2 CREB1 MAP3K1 CHUK TRAF2 MAPK9 MAP3K14 MAPK10 CEBPA MAPK14 MAPK13 IKBKB PAK1 NFKBIA MAPK1 RPS6KA3 JUN RPS6KA2 MAP3K3 MAPK11 ELK1 SP1 MAP3K12 MKNK2 MAP2K2 MAX RAF1 MAP2K7 MAP4K5 PAK2 MAPK7 MAPK8 FOS MAP3K11 RPS6KA4 MEF2D RPS6KA1 MAPK12 MAP2K5 SHC1 RELA MAP3K2 ATF2 MYC MAP4K4 MEF2BNB-MEF2B RAC1 MAP2K1 MKNK1 MAP3K9 MAPK3 MAP3K7 MAP3K5 MEF2A PID_FOXO_PATHWAY%MSIGDB_C2%PID_FOXO_PATHWAY PID_FOXO_PATHWAY G6PC YWHAB YWHAQ CDKN1B YWHAG YWHAH MST1 YWHAZ EP300 RAN CSNK1A1 CSNK1D CSNK1E SIRT1 RBL2 CHUK KAT2B MAPK9 CTNNB1 ZFAND5 CSNK1G3 USP7 CAT MAPK10 CSNK1G2 CSNK1G1 BCL2L11 FBXO32 SOD2 IKBKB CCNB1 SFN GADD45A CREBBP RALB FOXO4 BCL6 RALA CDK2 FOXO1 FASLG SKP2 MAPK8 PLK1 FOXO3 XPO1 YWHAE AKT1 SGK1 PID_TCR_JNK_PATHWAY%MSIGDB_C2%PID_TCR_JNK_PATHWAY PID_TCR_JNK_PATHWAY MAPK8 GRAP2 CRK LAT LCP2 CRKL MAP3K8 DBNL JUN MAP4K1 MAP2K4 PRKCB MAP3K1 MAP3K7 BIOCARTA_ATRBRCA_PATHWAY%MSIGDB_C2%BIOCARTA_ATRBRCA_PATHWAY BIOCARTA_ATRBRCA_PATHWAY FANCE FANCG FANCF RAD50 BRCA2 FANCD2 CHEK1 CHEK2 TP53 BRCA1 RAD17 ATM RAD1 NBN ATR RAD9A TREX1 RAD51 MRE11A HUS1 FANCC PID_ERBB1_RECEPTOR_PROXIMAL_PATHWAY%MSIGDB_C2%PID_ERBB1_RECEPTOR_PROXIMAL_PATHWAY PID_ERBB1_RECEPTOR_PROXIMAL_PATHWAY PTPN11 STAT1 TLN1 PIK3CA HRAS PLCG1 GRB2 EGF SOS1 NCK2 GAB1 GNAI3 GNAI1 PIK3CD PIK3R3 PIK3R2 PIK3CB STAT3 WASL SRC PTK2 SHC1 PIK3R1 PAK1 EGFR NRAS PTPN1 MAPK1 GSN PTPN6 NCK1 PIP5K1C MAPK3 RASA1 KRAS BIOCARTA_SODD_PATHWAY%MSIGDB_C2%BIOCARTA_SODD_PATHWAY BIOCARTA_SODD_PATHWAY TRAF2 TNF TNFRSF1A BAG4 CASP8 TRADD FADD RIPK1 TNFRSF1B BIRC3 BIOCARTA_TOLL_PATHWAY%MSIGDB_C2%BIOCARTA_TOLL_PATHWAY BIOCARTA_TOLL_PATHWAY TIRAP TLR10 NFKB1 TLR6 TLR3 EIF2AK2 ELK1 TRAF6 ECSIT IRAK1 IKBKG MAP2K6 MAP2K3 TOLLIP MAP2K4 PPARA MAP3K1 MYD88 CHUK MAPK8 FOS MAP3K14 TLR9 TAB2 TLR7 TAB1 TLR4 TLR2 MAPK14 IKBKB NFKBIA RELA JUN LY96 MAP3K7 CD14 PGLYRP1 BIOCARTA_BARR_MAPK_PATHWAY%MSIGDB_C2%BIOCARTA_BARR_MAPK_PATHWAY BIOCARTA_BARR_MAPK_PATHWAY MAP2K2 ARRB1 GNGT1 GNB1 MAPK1 ADCY1 PLCB1 RAF1 DNM1 MAP2K1 MAPK3 GNAS BIOCARTA_NKCELLS_PATHWAY%MSIGDB_C2%BIOCARTA_NKCELLS_PATHWAY BIOCARTA_NKCELLS_PATHWAY HLA-A B2M LAT PTK2B PIK3CA KLRC2 SYK KLRC3 KLRC4 KLRD1 PIK3R1 KLRC1 PAK1 IL18 PTPN6 ITGB1 MAP2K1 RAC1 VAV1 MAPK3 BIOCARTA_IGF1MTOR_PATHWAY%MSIGDB_C2%BIOCARTA_IGF1MTOR_PATHWAY BIOCARTA_IGF1MTOR_PATHWAY PDPK1 MTOR RPS6KB1 PIK3CA EIF2B5 IGF1R EIF2S2 PTEN EIF2S1 PIK3R1 PPP2CA EIF2S3 INPPL1 GSK3B EIF4E PDK2 IGF1 EIF4EBP1 AKT1 RPS6 BIOCARTA_FAS_PATHWAY%MSIGDB_C2%BIOCARTA_FAS_PATHWAY BIOCARTA_FAS_PATHWAY DAXX PTPN13 RB1 RIPK2 FAS FASLG CASP7 LMNB2 LMNB1 CASP6 CASP8 CASP10 CASP3 FADD ARHGDIB DFFB DFFA CFLAR PARP1 MAP2K4 PAK2 SPTAN1 MAP3K1 MAPK8 LMNA PRKDC PAK1 FAF1 JUN MAP3K7 BIOCARTA_GABA_PATHWAY%MSIGDB_C2%BIOCARTA_GABA_PATHWAY BIOCARTA_GABA_PATHWAY GABRA2 GABRA1 GABRA6 GABRA5 GABRA4 GABRA3 DNM1 GPHN GABARAP SRC BIOCARTA_GLYCOLYSIS_PATHWAY%MSIGDB_C2%BIOCARTA_GLYCOLYSIS_PATHWAY BIOCARTA_GLYCOLYSIS_PATHWAY PGK1 PKLR GPI PGAM1 ENO1 PFKL HK1 TPI1 GAPDH ALDOB BIOCARTA_NUCLEARRS_PATHWAY%MSIGDB_C2%BIOCARTA_NUCLEARRS_PATHWAY BIOCARTA_NUCLEARRS_PATHWAY NR0B2 ABCC3 ABCB1 ABCB4 NR1I3 ABCB11 CYP1A2 CYP2E1 NR1H4 NR1H3 RARA PPARD PPARA PPARG PID_HES_HEY_PATHWAY%MSIGDB_C2%PID_HES_HEY_PATHWAY PID_HES_HEY_PATHWAY RCAN1 ID1 PTF1A NEUROG3 RB1 CDKN1B GATA4 HES1 YY1 TWIST1 EP300 JAK2 TCF3 GATA1 PARP1 NOTCH1 BGLAP NCOA1 MYOD1 ARNT NCOR1 KDR STAT3 AR CAMK2D HDAC1 HIF1A CD4 RBBP8 MAML2 NCOR2 KDM1A MAML1 GATA6 MYB RUNX2 CTBP1 RBPJ E2F1 ASCL1 HEY1 CREBBP HEY2 SPEN TLE1 GHR HES6 GAA BIOCARTA_TCRA_PATHWAY%MSIGDB_C2%BIOCARTA_TCRA_PATHWAY BIOCARTA_TCRA_PATHWAY PTPRC FYN CD247 HLA-DRA LCK HLA-DRB1 ZAP70 CD3G CD3E CD3D CD4 BIOCARTA_MTOR_PATHWAY%MSIGDB_C2%BIOCARTA_MTOR_PATHWAY BIOCARTA_MTOR_PATHWAY EIF4A1 PDPK1 MTOR TSC2 RPS6KB1 EIF4G1 PIK3CA PTEN EIF3A PIK3R1 PPP2CA EIF4B EIF4A2 TSC1 EIF4G3 EIF4G2 EIF4E PDK2 EIF4EBP1 AKT1 MKNK1 RPS6 FKBP1A PID_INTEGRIN3_PATHWAY%MSIGDB_C2%PID_INTEGRIN3_PATHWAY PID_INTEGRIN3_PATHWAY LAMC1 THY1 PLAUR VEGFA L1CAM VTN TGFBR2 COL1A1 LAMB1 TGFBI PLAU FBN1 SPHK1 COL4A1 ITGA2B COL4A4 CYR61 CD47 COL4A3 COL4A6 COL4A5 SDC4 EDIL3 TNC FGB FGA FGG THBS1 KDR SDC1 COL1A2 FN1 IBSP ITGB3 PDGFB PECAM1 F11R SPP1 PVR LAMA4 ITGAV HMGB1 PDGFRB PID_RAC1_REG_PATHWAY%MSIGDB_C2%PID_RAC1_REG_PATHWAY PID_RAC1_REG_PATHWAY TIAM1 ARHGEF7 MCF2 ARHGEF6 DEF6 ELMO1 DOCK2 SOS1 NGEF PREX1 DOCK6 RALBP1 RAP1GDS1 ARHGAP17 PREX2 CHN1 DOCK1 TIAM2 SPATA13 ARHGEF2 ARHGAP9 KALRN TRIO RACGAP1 ARHGEF25 CHN2 ABR ABI1 RAC1 RASGRF2 VAV1 RASGRF1 EPS8 ARHGAP1 ARHGDIA BCR VAV3 VAV2 PID_TOLL_ENDOGENOUS_PATHWAY%MSIGDB_C2%PID_TOLL_ENDOGENOUS_PATHWAY PID_TOLL_ENDOGENOUS_PATHWAY TIRAP TLR6 RHOA TLR3 IRAK2 IRAK1 IKBKG IRAK4 MYD88 CHUK SFTPA1 VCAN S100A9 BGN TICAM1 S100A8 TLR1 TLR4 SAA1 TLR2 IKBKB HSPD1 HMGB1 LY96 CD14 BIOCARTA_HIVNEF_PATHWAY%MSIGDB_C2%BIOCARTA_HIVNEF_PATHWAY BIOCARTA_HIVNEF_PATHWAY DAXX TNF TRAF1 NFKB1 RB1 FAS BCL2 XIAP CASP7 BAG4 CASP8 TRADD CASP3 FADD CASP2 APAF1 RIPK1 CFLAR TNFRSF1B SPTAN1 BIRC2 MAP3K1 CHUK BIRC3 CRADD TRAF2 TNFRSF1A MAP3K14 ACTG1 PSEN2 CDK11A CDK11B NFKBIA MDM2 FASLG NUMA1 LMNB2 LMNB1 CASP9 CASP6 ARHGDIB DFFB DFFA PARP1 MAP2K7 PAK2 MAPK8 LMNA PRKDC CYCS PRKCD PTK2 RELA GSN PSEN1 BID RASA1 MAP3K5 ST_ERK1_ERK2_MAPK_PATHWAY%MSIGDB_C2%ST_ERK1_ERK2_MAPK_PATHWAY ST_ERK1_ERK2_MAPK_PATHWAY NFKB1 SOS2 BRAF GRB2 SOS1 MKNK2 MAP2K2 ATF1 ARAF MAP3K8 CREB3 KAT5 CREB5 CREB1 BAD RPS6KA1 TRAF3 SHC1 DUSP6 MAPK1 RPS6KA3 RAP1A EIF4E RPS6KA2 EEF2K MKNK1 DUSP4 MAP2K1 MAPK3 DUSP9 MOS KLF6 BIOCARTA_ATM_PATHWAY%MSIGDB_C2%BIOCARTA_ATM_PATHWAY BIOCARTA_ATM_PATHWAY MAPK8 NFKB1 RAD50 CDKN1A CHEK1 MDM2 CHEK2 TP53 BRCA1 ATM NBN TP73 NFKBIA RBBP8 RELA ABL1 JUN GADD45A RAD51 MRE11A PID_HDAC_CLASSII_PATHWAY%MSIGDB_C2%PID_HDAC_CLASSII_PATHWAY PID_HDAC_CLASSII_PATHWAY MEF2C YWHAB HDAC10 GNB1 HDAC11 TUBA1B RFXANK TUBB2A BCL6 SRF BCOR ANKRA2 RANGAP1 HDAC5 HDAC3 HDAC4 RAN GATA1 HDAC9 HDAC6 RANBP2 GNG2 ADRBK1 SUMO1 GATA2 HDAC7 CAMK4 XPO1 NCOR2 YWHAE NR3C1 UBE2I ESR1 HSP90AA1 BIOCARTA_CDK5_PATHWAY%MSIGDB_C2%BIOCARTA_CDK5_PATHWAY BIOCARTA_CDK5_PATHWAY MAP2K2 CDK5R1 MAPK1 RAF1 NGFR HRAS MAP2K1 NGF EGR1 MAPK3 CDK5 SA_B_CELL_RECEPTOR_COMPLEXES%MSIGDB_C2%SA_B_CELL_RECEPTOR_COMPLEXES SA_B_CELL_RECEPTOR_COMPLEXES FOS ELK1 PAPPA HRAS RPS6KA1 GRB2 SYK SOS1 SHC1 MAPK1 MAPK8IP3 ATF2 JUN RPS6KA3 BLNK MAP2K1 RAC1 VAV1 MAPK3 MAP3K1 LYN BCR VAV3 VAV2 PID_ILK_PATHWAY%MSIGDB_C2%PID_ILK_PATHWAY PID_ILK_PATHWAY SNAI1 ARHGEF7 RHOG ARHGEF6 PPP1R12A CKAP5 LIMS3L ILK ILKAP GIT2 TACC3 PPP1R14A TNS1 LIMS3 PPP1R14B PPP1R14C PARVA GSK3B PARVB ZEB1 ZYX PARVG RUVBL2 NCK2 NACA RUVBL1 PARP1 CDC37 ELMO2 CREB1 MYL9 LIMS2 LIMS1 CTNNB1 ACTN1 PXN AURKA RICTOR IQGAP1 XPO1 CDC42 CCND1 JUN DIAPH1 AKT1 RAC1 HSP90AA1 PID_S1P_META_PATHWAY%MSIGDB_C2%PID_S1P_META_PATHWAY PID_S1P_META_PATHWAY GNA13 GNA15 GNA11 GNA12 GNAO1 GNAQ S1PR3 S1PR2 S1PR1 ABCC1 SPHK1 SPHK2 SGPP1 SGPL1 S1PR5 S1PR4 GNAZ GNAI3 GNAI1 GNAI2 GNA14 PID_ARF_3PATHWAY%MSIGDB_C2%PID_ARF_3PATHWAY PID_ARF_3PATHWAY CLTA ASAP1 GGA3 ARFIP2 ARF1 COPA PLD2 KDELR1 GBF1 CLTB CD4 PIP5K1A ARFGAP1 CYTH2 AP2A1 RAC1 AP2M1 GOSR2 USO1 PID_HEDGEHOG_2PATHWAY%MSIGDB_C2%PID_HEDGEHOG_2PATHWAY PID_HEDGEHOG_2PATHWAY PIK3CA ADRBK1 HHIP STIL PTCH2 LRP2 PTHLH GLI2 PIK3R1 HHAT SMO SHH BOC CDON LRPAP1 IHH TGFB2 PTCH1 DHH ARRB2 AKT1 GAS1 BIOCARTA_ERYTH_PATHWAY%MSIGDB_C2%BIOCARTA_ERYTH_PATHWAY BIOCARTA_ERYTH_PATHWAY IL6 KITLG IL9 CCL3 IL1A IL11 CSF3 TGFB2 CSF2 TGFB1 EPO IGF1 TGFB3 FLT3 IL3 PID_EPHA_FWDPATHWAY%MSIGDB_C2%PID_EPHA_FWDPATHWAY PID_EPHA_FWDPATHWAY EPHA4 FYN YES1 ARHGEF15 RHOA CRK FGR HCK LCK CRKL PLCG1 NGEF CBL PIK3CG EPHA5 EFNA1 CDK5 PIK3R6 EPHA7 PIK3R5 EPHA6 EPHA8 EFNA3 EFNA2 EPHA1 EPHA3 ROCK1 EPHA2 EFNA5 SRC BLK LYN VAV3 VAV2 PID_ERB_GENOMIC_PATHWAY%MSIGDB_C2%PID_ERB_GENOMIC_PATHWAY PID_ERB_GENOMIC_PATHWAY NR0B2 SMARCA4 NCOA3 C3 SMARCE1 NR0B1 DDX54 ZNF14 ESR2 UBA3 SMARCB1 NEDD8 UBE2M NCOA1 NCOA2 BIOCARTA_NEUROTRANSMITTERS_PATHWAY%MSIGDB_C2%BIOCARTA_NEUROTRANSMITTERS_PATHWAY BIOCARTA_NEUROTRANSMITTERS_PATHWAY TH PNMT TPH1 GAD1 HDC DBH BIOCARTA_HSP27_PATHWAY%MSIGDB_C2%BIOCARTA_HSP27_PATHWAY BIOCARTA_HSP27_PATHWAY DAXX TNF MAPKAPK2 CYCS FAS BCL2 FASLG IL1A CASP9 MAPKAPK3 CASP3 APAF1 HSPB2 HSPB1 ACTA1 ST_WNT_BETA_CATENIN_PATHWAY%MSIGDB_C2%ST_WNT_BETA_CATENIN_PATHWAY ST_WNT_BETA_CATENIN_PATHWAY MVP FSTL1 CBY1 CXXC4 AXIN1 SFRP1 NKD1 NKD2 APC CER1 TSHB ANKRD6 DACT1 RPSA AXIN2 SENP2 DKK2 DKK3 DKK4 PTPRA CSNK1A1 GSK3B DVL1 CTNNB1 PIN1 DKK1 WIF1 GSK3A PSEN1 AKT2 AKT1 LRP1 FRAT1 AKT3 PID_HDAC_CLASSIII_PATHWAY%MSIGDB_C2%PID_HDAC_CLASSIII_PATHWAY PID_HDAC_CLASSIII_PATHWAY TUBA1B CDKN1A TUBB2A BAX XRCC6 SIRT7 FOXO1 SIRT2 SIRT3 EP300 HDAC4 SIRT1 PPARGC1A KAT2B MYOD1 ACSS2 FHL2 HOXA10 HIST1H1E ACSS1 MEF2D TP53 FOXO3 CREBBP FOXO4 ST_INTERLEUKIN_13_PATHWAY%MSIGDB_C2%ST_INTERLEUKIN_13_PATHWAY ST_INTERLEUKIN_13_PATHWAY JAK2 IL13 IL13RA2 IL13RA1 IL4R TYK2 JAK1 PID_CD8_TCR_PATHWAY%MSIGDB_C2%PID_CD8_TCR_PATHWAY PID_CD8_TCR_PATHWAY RASGRP1 PDPK1 LAT LCK HRAS GRB2 SOS1 PRKCE MAP3K8 IKBKG CD86 CHUK HLA-A CD8A B2M MAP3K14 CD3G CD3E CD3D IKBKB PTPRC NRAS CD28 CD247 RAP1A PRF1 KRAS FYN TRAF6 BCL10 MALT1 PLCG1 CD80 CBL PRKCQ PRKCB PRKCA GRAP2 LCP2 RASSF5 ZAP70 CD8B STIM1 ORAI1 CARD11 SHC1 PAG1 TRPV6 PTPN6 AKT1 CSK VAV1 RASGRP2 BIOCARTA_PTEN_PATHWAY%MSIGDB_C2%BIOCARTA_PTEN_PATHWAY BIOCARTA_PTEN_PATHWAY PDPK1 PIK3CA CDKN1B BCAR1 GRB2 SOS1 PTEN FASLG PTK2 SHC1 ILK PIK3R1 FOXO3 MAPK1 PDK2 ITGB1 AKT1 MAPK3 PID_P38_GAMMA_DELTA_PATHWAY%MSIGDB_C2%PID_P38_GAMMA_DELTA_PATHWAY PID_P38_GAMMA_DELTA_PATHWAY PKN1 MAPT CCND1 SNTA1 MAP2K6 MAP2K3 EEF2K MAPK12 MAPK13 STMN1 PID_FRA_PATHWAY%MSIGDB_C2%PID_FRA_PATHWAY PID_FRA_PATHWAY ITGB4 CDKN2A DCN PLAUR DMTF1 MGP IVL ATF4 MMP1 SP1 CCL2 NOS3 PLAU EP300 NFATC2 BGLAP NFATC1 CCNA2 MMP2 IL6 COL1A2 FOSL2 MMP9 GJA1 CXCL8 HMOX1 CCND1 JUN NFATC3 TXLNG LAMA3 THBD JUNB FOSL1 JUND LIF USF2 BIOCARTA_AHSP_PATHWAY%MSIGDB_C2%BIOCARTA_AHSP_PATHWAY BIOCARTA_AHSP_PATHWAY FECH ALAS2 UROS CPOX HBB HBA2 HBA1 ALAD ALAS1 UROD GATA1 HMBS AHSP ST_P38_MAPK_PATHWAY%MSIGDB_C2%ST_P38_MAPK_PATHWAY ST_P38_MAPK_PATHWAY NFKB1 MAPKAPK2 MAPKAPK5 MAPK11 SRF ELK1 TRAF6 MKNK2 NR2C2 ATF1 MAP3K4 IL1R1 CREB3 MAP2K6 MAP2K3 MAP3K10 CREB5 MAP2K4 CREB1 DUSP1 MYEF2 TAB2 TAB1 MAPK12 MAPK14 MAPK13 MAPK1 CDC42 EIF4E HSPB1 GADD45A EEF2K AKT1 MKNK1 MAP3K7 MAP3K5 DUSP10 BIOCARTA_IL7_PATHWAY%MSIGDB_C2%BIOCARTA_IL7_PATHWAY BIOCARTA_IL7_PATHWAY FYN NMI IL7R PTK2B PIK3CA IL7 LCK BCL2 STAT5A STAT5B PIK3R1 IL2RG EP300 PIK3CG CREBBP JAK3 JAK1 BIOCARTA_PLATELETAPP_PATHWAY%MSIGDB_C2%BIOCARTA_PLATELETAPP_PATHWAY BIOCARTA_PLATELETAPP_PATHWAY F9 F11 SERPINE1 F2 PLAU COL4A2 COL4A1 APP COL4A4 COL4A3 PLAT COL4A6 COL4A5 PLG SIG_BCR_SIGNALING_PATHWAY%MSIGDB_C2%SIG_BCR_SIGNALING_PATHWAY SIG_BCR_SIGNALING_PATHWAY ITPR3 BTK NR0B2 INPP5D PIK3CA BCL2 SOS2 GRB2 PPP1R13B SOS1 GSK3B RAF1 MAP4K1 NFATC2 PIK3CD NFATC1 PPP3CA PPP3CB PPP3CC FLOT1 FLOT2 BAD CD81 CR2 CD22 SYK SHC1 PIK3R1 PTPRC GSK3A MAPK1 CD19 DAG1 BLNK AKT2 PLCG2 AKT1 AKT3 CSK MAPK3 VAV1 ITPR1 PDK1 LYN BCR ITPR2 PID_IL12_2PATHWAY%MSIGDB_C2%PID_IL12_2PATHWAY PID_IL12_2PATHWAY STAT1 NFKB1 MTOR IL2 LCK IL2RA IL2RB CCL4 RAB7A CCL3 JAK2 IL18 MAP2K6 MAP2K3 IL4 IL1B NFKB2 HLA-A CD8A B2M STAT3 CD3G CD3E CD3D IL18RAP MAPK14 EOMES CD4 RELB PPP3R1 CD247 HLX IL12B TBX21 IL12A GADD45B GZMA GADD45G SOCS1 STAT6 RIPK2 FASLG IFNG STAT5A IL1R1 HLA-DRA HLA-DRB1 PPP3CA PPP3CB FOS GZMB STAT4 TYK2 IL12RB1 CCR5 CD8B IL18R1 IL12RB2 IL2RG SPHK2 RELA NOS2 ATF2 BIOCARTA_TCR_PATHWAY%MSIGDB_C2%BIOCARTA_TCR_PATHWAY BIOCARTA_TCR_PATHWAY PTPN7 FYN NFKB1 LAT PIK3CA ELK1 LCK HRAS PLCG1 GRB2 SOS1 PIK3CG RAF1 MAP2K4 PRKCB NFATC2 MAP3K1 PRKCA NFATC1 PPP3CA MAPK8 PPP3CB PPP3CC FOS NFATC4 CALM3 CALM1 CALM2 ZAP70 CD3G CD3E CD3D SHC1 PIK3R1 NFKBIA CD247 RELA JUN NFATC3 RAC1 MAP2K1 MAPK3 VAV1 RASA1 BIOCARTA_CTCF_PATHWAY%MSIGDB_C2%BIOCARTA_CTCF_PATHWAY BIOCARTA_CTCF_PATHWAY CDKN2A CD79B MTOR CD79A TGFBR1 TGFBR2 RPS6KB1 TGFBR3 PIK3CA CDKN1B MDM2 TP53 SMAD1 PTEN PIK3R1 PPP2CA SMAD5 TGFB2 SMAD4 TGFB1 MYC PIK3CG TGFB3 BIOCARTA_MYOSIN_PATHWAY%MSIGDB_C2%BIOCARTA_MYOSIN_PATHWAY BIOCARTA_MYOSIN_PATHWAY GNGT1 ARHGEF10 ARHGEF12 GNB1 ARHGEF15 ARHGEF17 ARHGEF7 ARHGEF6 MYL7 ARHGEF18 ARHGEF3 PKN1 ARHGEF5 PPP1R12B PLCB1 PRKCB PRKCA ARHGEF1 ARHGEF2 GNA13 GNA12 ROCK1 GNAQ MYLK ARHGEF16 ARHGEF19 ARHGEF9 ARHGAP5 ARHGEF4 MYL2 ARHGEF11 PID_PRL_SIGNALING_EVENTS_PATHWAY%MSIGDB_C2%PID_PRL_SIGNALING_EVENTS_PATHWAY PID_PRL_SIGNALING_EVENTS_PATHWAY RHOA TUBA1B CCNE1 CDKN1A AGT ROCK1 RABGGTB CDK2 RHOC BCAR1 RABGGTA PTP4A1 PTP4A2 SRC PTP4A3 ATF5 ITGA1 MAPK1 ITGB1 RAC1 EGR1 MAPK3 CCNA2 PID_CDC42_REG_PATHWAY%MSIGDB_C2%PID_CDC42_REG_PATHWAY PID_CDC42_REG_PATHWAY APC ARHGEF7 MCF2 ARHGEF6 GIT1 PLCG1 NGEF BCAR3 ITSN2 DOCK6 RALBP1 DOCK9 ARHGAP17 FGD1 DOCK10 DOCK11 DNMBP SPATA13 ITSN1 RACGAP1 ARHGEF9 ARHGEF25 CDC42 NME1 MCF2L FARP2 ARHGAP1 ARHGDIA VAV3 VAV2 BIOCARTA_FIBRINOLYSIS_PATHWAY%MSIGDB_C2%BIOCARTA_FIBRINOLYSIS_PATHWAY BIOCARTA_FIBRINOLYSIS_PATHWAY PLAU SERPINB2 CPB2 PLAT SERPINE1 F2 FGB F13A1 FGA PLG F2R FGG PID_NETRIN_PATHWAY%MSIGDB_C2%PID_NETRIN_PATHWAY PID_NETRIN_PATHWAY FYN YES1 RHOA NTN1 PIK3CA CAMK2A PLCG1 ELMO1 MAP2K2 AGAP2 DAPK1 DOCK1 MAP1B PITPNA UNC5A MYO10 UNC5B BCAR1 DCC WASL UNC5C SRC PTK2 TRIO PIK3R1 PAK1 MAPK1 CDC42 NCK1 RAC1 MAP2K1 MAPK3 PID_FCER1_PATHWAY%MSIGDB_C2%PID_FCER1_PATHWAY PID_FCER1_PATHWAY PTPN11 PTPN13 GAB2 NFKB1 LAT PIK3CA HRAS GRB2 SOS1 S1PR1 SPHK1 IKBKG MAP2K4 ITK MAP3K1 CHUK PXN SYK IKBKB MAPK1 JUN LYN FCER1A BTK FCER1G FYN INPP5D PLCG1 PLD2 MAP2K2 PLA2G4A CBL RAF1 MAP2K7 PRKCB PAK2 NFATC2 DUSP1 MAPK8 FOS LCP2 PTK2 SHC1 PIK3R1 WIPF1 CBLB RELA LAT2 DOK1 PPAP2A HCLS1 FER MS4A2 PLA2G1B AKT1 KLRG1 MAP2K1 FCGR2B VAV1 RASA1 MAPK3 BIOCARTA_COMP_PATHWAY%MSIGDB_C2%BIOCARTA_COMP_PATHWAY BIOCARTA_COMP_PATHWAY C1QB C1QA C3 MBL2 CFB CFD C1S C1R C8A C2 C1QC C4B C4A C6 C5 C7 C9 MASP2 MASP1 BIOCARTA_SET_PATHWAY%MSIGDB_C2%BIOCARTA_SET_PATHWAY BIOCARTA_SET_PATHWAY GZMB GZMA NME1 DFFB DFFA SET CREBBP ANP32A APEX1 HMGB2 PRF1 PID_BETA_CATENIN_NUC_PATHWAY%MSIGDB_C2%PID_BETA_CATENIN_NUC_PATHWAY PID_BETA_CATENIN_NUC_PATHWAY YWHAB TNIK FGF4 APC YWHAQ TRRAP YWHAG YWHAH YWHAZ EP300 CYR61 ADCY7 ZCCHC12 CHD8 MED12 CTNNB1 SALL4 TLE4 DKK1 MYOG TLE2 KRT1 SSPO CTNNBIP1 AES HDAC1 MDFIC TBL1XR1 MT-CO2 TCF7 CACNA1G CAMK4 IGF2BP1 TBL1X CXCL8 TCF7L2 PITX2 SFN CDX4 CDX1 KCNIP4 CCND1 KLF4 JUN BCL9 CDH1 CTBP1 SP5 LEF1 TCF4 NEUROG1 MYF5 TLE1 CCND2 CDKN2A CBY1 SMARCA4 SNAI2 AXIN2 HBP1 DKK4 RUVBL2 DVL3 NCOA2 MMP2 T VCAN TCF7L1 HDAC2 AR MMP9 XPO1 CUL1 SKP1 TERT YWHAE MYC MITF ID2 INCENP BIOCARTA_GH_PATHWAY%MSIGDB_C2%BIOCARTA_GH_PATHWAY BIOCARTA_GH_PATHWAY SOCS1 PIK3CA SRF HRAS HNF1A PLCG1 GRB2 SOS1 INS STAT5A STAT5B JAK2 PIK3CG RAF1 PRKCB GH1 PRKCA RPS6KA1 INSR SLC2A4 SHC1 PIK3R1 IRS1 MAPK1 PTPN6 MAP2K1 MAPK3 GHR NABA_MATRISOME%MSIGDB_C2%NABA_MATRISOME NABA_MATRISOME S100A2 COL16A1 HGF COL13A1 IGFBP3 COL14A1 COL11A1 COL12A1 COL11A2 COL19A1 COL10A1 COL28A1 COL26A1 COL27A1 COL24A1 TGFA COL25A1 COL22A1 COL23A1 COL2A1 COL5A1 COL5A3 COL7A1 COL5A2 COL9A1 COL20A1 COL8A2 COL21A1 COL8A1 COL9A3 COL9A2 LIF CX3CL1 CTSD MMP2 SERPINB5 VCAN SPP1 GDF15 SSPO IGFBP1 CTGF TGFB2 TGFB1 TGFB3 SDC4 TNC PLG THBS1 FGF2 FGF6 MDK CCL5 COL3A1 COL1A2 FN1 F2 MMP9 CXCL12 ADAM12 PDGFB INS RELN COL17A1 EGF MST1 IL1A REG1A ADAMDEC1 PRSS1 CNTF SERPINE2 SERPINE3 CLEC10A ISM1 ISM2 CRHBP PRSS3 PRSS2 CCBE1 SERPINF1 SERPINF2 CLEC11A LGALS14 LGALS16 HCFC2 HCFC1 FLG2 LGALS13 LGALS12 SERPING1 FREM1 FREM2 FREM3 PROL1 FLG CELA3A CELA3B DHH PDGFA ADAMTS12 ADAMTS10 ADAMTS16 ADAMTS15 HPX ADAMTS14 ADAMTS13 ADAMTS19 S100A16 ADAMTS18 PDGFD ADAMTS17 PDGFC SERPINH1 S100A13 S100A12 COL1A1 S100A14 ELANE S100A11 S100A10 WNT10B ST14 WNT10A HRNR TNFSF4 SERPINI2 TNFSF9 F13B TNFSF8 SERPINI1 HRG SERPINA11 SERPINA2 SFTA2 SERPINA12 SFTA3 ANXA8L1 SERPINA1 WFIKKN1 SERPINA10 WFIKKN2 SERPINA9 C1QTNF9 SERPINA6 SERPINA7 AREG MMP21 SERPINA4 MMP20 SERPINA5 ADAMTSL1 C1QTNF4 C17orf58 C1QTNF3 SHH MMP25 C1QTNF2 MMP24 C1QTNF1 ADAMTSL5 MMP27 C1QTNF8 ADAMTSL4 MMP26 C1QTNF7 ADAMTSL3 C1QTNF6 ADAMTSL2 MMP28 C1QTNF5 TIMP2 ANXA6 ANXA7 TIMP3 ANXA8 ANXA9 TIMP1 FGFBP3 TIMP4 PF4V1 SERPINB3 SERPINB4 SERPINB1 FGFBP1 LEFTY1 ANXA1 FGFBP2 SERPINB2 ANXA2 ANXA3 ANXA4 ANXA5 WNT9B SERPINB9 WNT9A SERPINB7 PRSS12 SERPINB8 MMP10 RSPO1 CTHRC1 SERPINB6 MMP12 F7 MMP11 MMP14 IGFBP4 MMP13 F9 MMP16 ANGPTL7 MMP15 ANGPTL6 MMP17 ANGPTL3 MMP19 ANGPTL2 ANGPTL5 ANGPTL4 ANGPTL1 HBEGF SERPINB10 CCL14 SERPINB11 CCL13 SERPINB12 FIGF SERPINB13 CCL11 CTF1 SERPINC1 ADAM22 WNT8A ADAM21 WNT8B ADAM20 FSTL1 FSTL3 NTF4 ADAM29 LMAN1 ADAM28 CST11 FRZB ADAM23 NTF3 CCL19 CCL18 P4HTM LEFTY2 CCL17 CCL16 CCL15 CCL25 EGLN1 CCL24 CCL23 EGLN3 CCL22 EGLN2 F10 SERPIND1 CCL21 CCL20 WNT7B F12 ADAM33 BMP8A ADAM32 WNT7A BMP8B ADAM30 SULF1 PLXDC2 PLXDC1 AGT SULF2 CLCF1 CLC CRLF3 INHA CCL28 CCL27 CRLF1 PF4 CCL26 SEMA5A SEMA5B CSF3 CSF2 CLEC4M PLXND1 CSF1 EPO REG1B PLOD3 F13A1 PLOD2 PLOD1 CXCL13 FGF1 TNF CXCL14 FGF3 FGF4 FGF5 FGF7 FGF8 FGF9 CLEC5A PLXNC1 RPTN SEMA6B SEMA6C IFNA13 SEMA6A IFNA14 S100A1 IFNA16 SEMA6D FST IFNA17 PGF ADAM2 CLEC4A CLEC4C CLEC4D S100A6 ADAM9 S100A5 ADAM8 S100A4 ADAM7 S100A3 CLEC4E CLEC4F S100A9 CLEC4G S100A8 S100A7 IFNA10 REG3A SEMA7A PARM1 CSH2 CSH1 CHRD REG3G KNG1 TPO CLEC7A CPAMD8 PLXNA2 PLXNA1 PI3 PLXNA4 PLXNA3 IFNA21 AMBP BDNF KY IFNW1 TMPRSS15 CXCL10 CXCL11 INS-IGF2 P4HA1 P4HA2 P4HA3 CLEC6A PLXNB3 CSPG5 PLXNB2 PLXNB1 CSPG4 HPSE BMP10 FASLG ELFN2 ELFN1 TNFSF13B BMP15 ADAMTS4 S100A7A ADAMTS5 INSL6 ADAMTS2 ADAMTS3 CLEC1A ADAMTS1 ADAMTS8 CLEC1B INSL3 AMH ADAMTS9 ADAMTS6 CSTL1 HGFAC INSL5 ADAMTS7 MBL2 OVGP1 CFC1B ZFP91 NRG1 NRG2 C1QL4 NGF C1QL3 C1QL2 MUC5AC ADAMTS20 C1QL1 NRG3 MEP1B MEP1A NRG4 XCL2 XCL1 CERS1 ITIH5 ITIH4 ITIH3 ITIH2 SFTPA2 SEMA3C CLEC2L SEMA3D SEMA3A ITIH6 SEMA3B ITLN1 SEMA3G ITLN2 SEMA3E SEMA3F ITIH1 CLEC3A CLEC3B CCL8 CCL7 CCL4 CCL3 CCL2 CCL1 ANGPT4 SEMA4A ANGPT2 ANGPT1 SEMA4D SEMA4B SEMA4C SEMA4F SEMA4G CLEC2A CLEC2B LEP TLL2 TLL1 SFTPA1 CBLN4 CLEC2D CBLN3 CBLN2 CBLN1 IL1RN HPSE2 HHIP LGALSL LGALS4 LGALS3 LGALS2 IL36A LGALS1 IL36B OGFOD1 OGFOD2 TNFSF10 TNFSF11 IL12B IL12A LGALS9 LGALS8 LGALS7 HABP2 MUCL1 LMAN1L P3H2 P3H1 FLT3LG P3H3 EREG BTC SFRP4 SFRP1 SFRP2 ASTL SLPI IL23A CD109 PAPPA SFRP5 HMSD SDC2 EBI3 SDC3 A2M CTSA TNFSF18 TNFSF14 TNFSF15 REG4 TNFSF12 TNFSF13 IGF2 GDF2 IL36G CELA1 IGF1 GDF3 PPBP GDF6 GDF5 GDF7 IL1F10 CRNN GDF9 CD209 ARTN SDC1 TCHHL1 TDGF1 NODAL IFNA5 IL22 IFNA4 IFNA7 IL20 IFNA6 IFNA1 IL25 MSTN IL26 CTSZ IL24 IFNA2 CTSW CTSV CLEC9A PRL PCSK6 CHRDL2 PCSK5 CHRDL1 IFNA8 CTSS CTSO CTSL HYAL1 CTSK HYAL2 HYAL3 HYAL4 MUC12 CTSH MUC13 CTSG CTSF MUC15 CTSE CTSC CTSB IL10 SFTPB IL11 IL15 SFTPC SFTPD IL13 IL18 IL19 IL16 MMP23B IL1B FAM20B FAM20C FAM20A SPAM1 C1QB CSTB C1QA CSTA MEGF6 CST9 CST8 PTN CST7 CST6 CPN2 CST5 CST4 CST3 CST2 CST1 WIF1 GPC1 GPC3 GPC2 GPC5 GPC4 GPC6 GDF10 GDF11 IFNB1 IL37 IL34 VEGFB OSM VEGFC CSHL1 KAZALD1 VEGFA KITLG EPGN VWC2 IL17F IL17D MEGF8 IL17C IL17B C1QC IL17A MEGF9 FCN1 FCN2 FCN3 S100A7L2 CCL4L2 LOXL3 CLEC18C IHH LOXL4 CLEC18B PLAT LOXL1 CLEC18A LOXL2 TGM1 TGM7 NRTN TGM6 TGM5 PAMR1 TGM4 TGM3 TGM2 WNT5B ANXA13 WNT5A ADAM11 ANXA11 ADAM10 ANXA10 MUC3A LGALS9C LGALS9B ADAM19 ADAM18 ADAM17 EMCN LOX ADAM15 NCAN MASP2 MASP1 LPA HTRA3 CCL3L3 HTRA4 HTRA1 SCUBE2 WNT6 SCUBE3 BRINP2 SCUBE1 THPO FGF20 IL36RN WNT1 WNT2 BRINP3 FGF23 WNT3 FGF22 WNT4 FGF21 MUC16 PSPN WNT3A MUC17 CLEC17A A2ML1 INHBB INHBA BMP7 INHBC BMP6 BMP5 INHBE FGF17 BMP4 IL4 GH2 GH1 IL3 BMP3 FGF16 BMP2 IL6 BMP1 IL5 FGF14 BGN GDNF IL7 FGF19 IL9 FGF18 FGF13 FGF12 MUC20 MUC21 FGF11 MUC22 FGF10 CXCL6 CXCL9 CXCL8 WNT2B EDA MEGF10 MEGF11 NGLY1 PZP TCHH CLEC14A CXCL1 CXCL3 CXCL2 CXCL5 VWC2L GRIFIN CELA2A EGFL7 CELA2B MMP7 EGFL6 MMP1 MMP3 MMP8 WNT16 C1QTNF9B GREM1 IFNG IFNE LTA IFNK LTB EGFL8 PAPPA2 CST9L COLEC12 COLEC11 COLEC10 CLEC12A CLEC12B MUC1 WNT11 MUC7 MUC4 MUC6 S100G MUC5B S100B CFC1 PIK3IP1 S100Z S100P SLIT2 VIT SPON2 SPON1 SPARC DMP1 GLDN TSKU HMCN2 EYS VWA5B2 VWA5B1 FNDC7 FNDC8 CRISPLD1 FNDC1 CRISPLD2 ANOS1 SPARCL1 MXRA5 DDX26B OTOG CILP BSPH1 SRPX ECM1 ECM2 TINAGL1 ELN RSPO2 RSPO3 TINAG RSPO4 SBSPON VWA5A VWA9 CDCP2 NOV PXDN MATN1 VWA1 VWA2 CRELD1 MFGE8 CRELD2 GAS6 MATN4 MATN3 MATN2 VWA7 TNXB VWCE EGFLAM SRPX2 BGLAP ABI3BP CILP2 VWA3A VWA3B DSPP SMOC2 LRG1 SMOC1 COMP EFEMP2 EFEMP1 BMPER DMBT1 IBSP TNN TNR SVEP1 TECTA TECTB POSTN IGFBP5 ADIPOQ IGFBP2 PCOLCE VWDE IGFALS EMID1 FBLN7 FBN2 FBN3 LTBP4 DPT FBLN1 LTBP2 AEBP1 DCN LTBP3 FBLN2 LTBP1 IL2 FBLN5 VTN IGFBP7 IGFBP6 AMELX AMELY AMBN CRIM1 PXDNL OTOL1 IGSF10 TGFBI FBN1 SNED1 TNFAIP6 WISP3 CYR61 WISP1 WISP2 EMILIN3 EMILIN2 EMILIN1 OIT3 EDIL3 FGB FGA VWF FGG MEPE ELSPBP1 MMRN1 MMRN2 ZP1 ZP3 ZP2 ZP4 PCOLCE2 FGL1 FGL2 NDNF THBS2 COCH POMZP3 THBS4 THSD4 THBS3 IGFBPL1 SLIT1 SLIT3 ZPLD1 COL18A1 LAMA5 LGI1 COL15A1 LGI4 LAMA2 LGI3 LAMC3 LGI2 LAMA1 TSPEAR NELL2 LAMA4 LAMA3 MFAP5 MFAP4 PAPLN NTN4 NELL1 NTN5 FRAS1 LAMC2 MFAP1 LAMC1 MFAP3 MGP NID1 MFAP2 NID2 NTN1 KCP NTN3 HMCN1 NTNG1 NTNG2 LAMB3 LAMB2 LAMB4 LAMB1 NPNT HSPG2 USH2A COLQ COL4A2 COL4A1 COL4A4 COL6A2 COL6A1 COL4A3 COL4A6 COL6A3 COL4A5 COL6A6 COL6A5 AGRN SERPINE1 PLAU OPTC OGN OMD PRG2 PRG4 PRG3 CHAD SPOCK2 SPOCK3 SPOCK1 BCAN EPYC FMOD PODNL1 KERA IMPG1 IMPG2 ASPN CHADL ESM1 PODN HAPLN3 HAPLN4 HAPLN1 HAPLN2 SRGN PRELP ACAN LUM NYX BIOCARTA_CLASSIC_PATHWAY%MSIGDB_C2%BIOCARTA_CLASSIC_PATHWAY BIOCARTA_CLASSIC_PATHWAY C1QB C1QA C3 C1S C1R C8A C2 C1QC C4B C4A C6 C5 C7 C9 BIOCARTA_IL2RB_PATHWAY%MSIGDB_C2%BIOCARTA_IL2RB_PATHWAY BIOCARTA_IL2RB_PATHWAY SOCS3 SOCS1 RPS6KB1 PIK3CA IL2RA CRKL HRAS IL2RB FAS BCL2 GRB2 SOS1 FASLG STAT5A STAT5B BCL2L1 CBL PIK3CG RAF1 CFLAR IKZF3 PPIA NMI FOS BAD SYK SHC1 PIK3R1 IL2RG IRS1 MAPK1 MYC PTPN6 E2F1 AKT1 JAK3 MAPK3 JAK1 PID_IL5_PATHWAY%MSIGDB_C2%PID_IL5_PATHWAY PID_IL5_PATHWAY PTPN11 SDCBP IL5 PIM1 PIK3CA GRB2 STAT5A STAT5B CISH PIK3R1 JAK2 CSF2RB LYN IL5RA PID_LKB1_PATHWAY%MSIGDB_C2%PID_LKB1_PATHWAY PID_LKB1_PATHWAY YWHAB MTOR YWHAQ YWHAG YWHAH YWHAZ GSK3B SMAD4 TSC1 CTSD CDC37 EZR CREB1 PRKACA BRSK1 CRTC2 MAPT BRSK2 PRKAA1 PRKAA2 TSC2 SMARCD3 CAB39 PRKAB1 STK11 MAP2 MARK4 MARK2 TP53 STRADA STK11IP STRADB MLST8 ETV4 PSEN2 STK26 SIK3 SIK1 RPTOR SIK2 SFN AKT1S1 YWHAE MYC PRKAG1 ESR1 HSP90AA1 PID_DNA_PK_PATHWAY%MSIGDB_C2%PID_DNA_PK_PATHWAY PID_DNA_PK_PATHWAY PRKDC XRCC6 POLM XRCC5 PNKP CSNK2A1 LIG4 DNTT CSNK2A2 APTX APLF POLL NHEJ1 CSNK2B DCLRE1C XRCC4 PID_TCR_PATHWAY%MSIGDB_C2%PID_TCR_PATHWAY PID_TCR_PATHWAY RASGRP1 PTPN11 PDPK1 GAB2 LAT LCK HRAS GRB2 SOS1 PRKCE MAP3K8 IKBKG MAP4K1 CD86 ITK CHUK MAP3K14 CD3G CD3E CD3D IKBKB CD4 PTPRC NRAS CD28 CD247 CDC42 DBNL RAP1A NCK1 KRAS FYN INPP5D TRAF6 BCL10 MALT1 PLCG1 PTEN CD80 CBL PRKCQ HLA-DRA HLA-DRB1 SLA2 WAS PRKCB STK39 FYB FLNA PRKCA SH3BP2 GRAP2 LCP2 RASSF5 ZAP70 STIM1 ORAI1 CARD11 SHC1 PAG1 TRPV6 PTPN6 AKT1 CSK VAV1 RASGRP2 PID_TCR_RAS_PATHWAY%MSIGDB_C2%PID_TCR_RAS_PATHWAY PID_TCR_RAS_PATHWAY PTPN7 FOS ELK1 HRAS BRAF NRAS MAPK1 MAP3K8 RAF1 MAP2K1 PRKCB MAPK3 PRKCA KRAS BIOCARTA_LEPTIN_PATHWAY%MSIGDB_C2%BIOCARTA_LEPTIN_PATHWAY BIOCARTA_LEPTIN_PATHWAY PRKAB2 PRKAA1 PRKAA2 LEPR PRKAG2 PRKAB1 PRKAG3 ACACA PRKAG1 LEP CPT1A SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES%MSIGDB_C2%SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES PAK3 MYH2 PAK4 VASP ROCK2 CFL2 FLNA PAK2 PAK7 PAK6 ACTR3 LIMK1 ACTR2 ROCK1 MYLK WASL ANGPTL2 MYLK2 ACTG1 GDI1 GDI2 ACTG2 PAK1 RPS4X RHO FLNC FSCN1 FSCN3 CDC42 WASF1 FSCN2 AKT1 PFN1 PFN2 CFL1 BIOCARTA_TOB1_PATHWAY%MSIGDB_C2%BIOCARTA_TOB1_PATHWAY BIOCARTA_TOB1_PATHWAY TOB2 TOB1 TGFBR1 IL2 TGFBR2 TGFBR3 IL2RA CD3G CD3E CD3D IFNG CD28 CD247 TGFB2 SMAD4 TGFB1 SMAD3 IL4 TGFB3 ST_G_ALPHA_S_PATHWAY%MSIGDB_C2%ST_G_ALPHA_S_PATHWAY ST_G_ALPHA_S_PATHWAY SNX13 CFB RAPGEF3 GAST CAMP BRAF SRC ASAH1 MAPK1 CREB3 RAF1 TERF2IP CREB5 RASGRF2 CREB1 BFAR PID_S1P_S1P4_PATHWAY%MSIGDB_C2%PID_S1P_S1P4_PATHWAY PID_S1P_S1P4_PATHWAY GNA13 RHOA GNA12 GNAO1 PLCG1 MAPK1 CDC42 S1PR5 S1PR4 GNAZ GNAI3 GNAI1 MAPK3 GNAI2 BIOCARTA_CHREBP2_PATHWAY%MSIGDB_C2%BIOCARTA_CHREBP2_PATHWAY BIOCARTA_CHREBP2_PATHWAY PPP2R3B YWHAB PKLR YWHAQ PPP2R1A PPP2R1B PPP2R4 YWHAG PPP2R5E YWHAH MLX PPP2R5B PPP2R3A YWHAZ PPP2CA PPP2R5C PPP2CB MLXIPL PPP2R2C PPP2R2B PPP2R2D PRKACA PPP2R5A PRKAA1 PRKAB2 PRKAA2 PRKAG2 PRKAB1 PRKAG3 ACACA FASN PPP2R5D YWHAE GCK PRKAR1B PRKAR2B PRKAG1 PPP2R2A PRKAR1A PRKACG PRKAR2A PRKACB BIOCARTA_LECTIN_PATHWAY%MSIGDB_C2%BIOCARTA_LECTIN_PATHWAY BIOCARTA_LECTIN_PATHWAY C3 MASP2 MBL2 MASP1 C8A C2 C4B C4A C6 C5 C7 C9 NABA_PROTEOGLYCANS%MSIGDB_C2%NABA_PROTEOGLYCANS NABA_PROTEOGLYCANS DCN HSPG2 OPTC OGN OMD PRG2 PRG4 PRG3 CHAD SPOCK2 SPOCK3 SPOCK1 BCAN EPYC VCAN FMOD PODNL1 BGN KERA IMPG1 IMPG2 ASPN CHADL ESM1 PODN HAPLN3 HAPLN4 HAPLN1 HAPLN2 SRGN PRELP ACAN NCAN LUM NYX BIOCARTA_IL6_PATHWAY%MSIGDB_C2%BIOCARTA_IL6_PATHWAY BIOCARTA_IL6_PATHWAY PTPN11 IL6 FOS STAT3 SRF ELK1 TYK2 HRAS CSNK2A1 GRB2 SOS1 IL6ST SHC1 IL6R CEBPB JAK2 JUN RAF1 MAP2K1 JAK3 MAPK3 JAK1 PID_IL27_PATHWAY%MSIGDB_C2%PID_IL27_PATHWAY PID_IL27_PATHWAY TNF STAT1 IL2 IL17A EBI3 STAT5A IFNG JAK2 TGFB1 IL18 IL1B IL27 GATA3 IL27RA IL6 STAT3 STAT4 STAT2 TYK2 IL12RB1 IL12RB2 IL6ST TBX21 IL12B IL12A JAK1 BIOCARTA_DREAM_PATHWAY%MSIGDB_C2%BIOCARTA_DREAM_PATHWAY BIOCARTA_DREAM_PATHWAY FOS KCNIP3 CREM OPRK1 PRKAR1B POLR2A JUN PRKAR2B PRKAR1A PRKACG CREB1 PRKAR2A MAPK3 PRKACB BIOCARTA_ECM_PATHWAY%MSIGDB_C2%BIOCARTA_ECM_PATHWAY BIOCARTA_ECM_PATHWAY FYN TLN1 RHOA PIK3CA ROCK1 PXN MYLK HRAS SRC PTK2 SHC1 PIK3R1 ITGA1 GSN ARHGAP5 MAPK1 PIK3CG DIAPH1 RAF1 ITGB1 MYL2 PFN1 MAP2K1 MAPK3 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES%MSIGDB_C2%SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES YWHAB YWHAQ RPS6KB1 PIK3CA YWHAG SOS2 YWHAH GRB2 SOS1 YWHAZ PARD6A PIK3CD SERPINB6 F2RL2 CAP1 LNPEP NPY4R SLC2A4 BRD4 SORBS1 GSK3A IRS1 MAPK1 SFN IRS2 CDC42 CYTH3 RPS6KA3 RPS6KA2 AKT2 AKT3 PDK1 CDKN2A FOXO1 PTEN INPPL1 IRS4 CBL GSK3B RAF1 PARD3 IGFBP1 FLOT1 FLOT2 RPS6KA1 SHC1 PIK3R1 PTPN1 YWHAE AKT1 MAPK3 BIOCARTA_PTDINS_PATHWAY%MSIGDB_C2%BIOCARTA_PTDINS_PATHWAY BIOCARTA_PTDINS_PATHWAY BTK ARHGEF2 PDPK1 ARF1 BAD PFKM RPS6KB1 JAG1 PLCG1 RAB5A PRKCE GSK3A PRKCZ EEA1 PFKP GSK3B PFKL AKT1 AP2A1 RAC1 AP2M1 LYN VAV2 ST_MYOCYTE_AD_PATHWAY%MSIGDB_C2%ST_MYOCYTE_AD_PATHWAY ST_MYOCYTE_AD_PATHWAY ITPR3 APC CFB CAV3 KAT5 GNAI1 GAST CAMP GNAQ PTX3 ASAH1 RHO MAPK1 PITX2 EPHB2 KCNJ3 KCNJ5 RYR1 KCNJ9 ADRB1 DAG1 PLN AKT1 RAC1 ITPR1 ITPR2 DLG4 PID_INTEGRIN_A9B1_PATHWAY%MSIGDB_C2%PID_INTEGRIN_A9B1_PATHWAY PID_INTEGRIN_A9B1_PATHWAY VEGFA ITGA9 CSF2RA ADAM2 ITGB1 TNC ADAM8 TGM2 VCAM1 PXN FN1 BCAR1 SRC ADAM12 ADAM15 SPP1 NOS2 CSF2 FIGF RAC1 F13A1 SAT1 KCNJ15 VEGFC PAOX BIOCARTA_CK1_PATHWAY%MSIGDB_C2%BIOCARTA_CK1_PATHWAY BIOCARTA_CK1_PATHWAY PPP3CA GRM1 CDK5R1 PPP1R1B DRD1 PPP2CA DRD2 CSNK1D PRKAR1B PLCB1 PRKAR2B PRKAR1A PRKACG PRKAR2A PPP1CA CDK5 PRKACB BIOCARTA_IL10_PATHWAY%MSIGDB_C2%BIOCARTA_IL10_PATHWAY BIOCARTA_IL10_PATHWAY STAT1 TNF IL6 STAT3 STAT6 STAT4 STAT2 IL10RB IL10RA BLVRB BLVRA STAT5A STAT5B IL1A IL10 HMOX1 JAK1 PID_IL23_PATHWAY%MSIGDB_C2%PID_IL23_PATHWAY PID_IL23_PATHWAY TNF STAT1 SOCS3 NFKB1 IL2 IL17F PIK3CA IL23A IL17A STAT5A IFNG CCL2 IL23R ALOX12B JAK2 MPO IL18 IL19 IL1B IL6 STAT3 STAT4 TYK2 IL12RB1 CD3E IL18R1 IL18RAP PIK3R1 CD4 ITGA3 NFKBIA CXCL9 RELA IL12B IL24 NOS2 CXCL1 PID_INTEGRIN4_PATHWAY%MSIGDB_C2%PID_INTEGRIN4_PATHWAY PID_INTEGRIN4_PATHWAY ITGB4 LAMC2 LAMC1 LAMA5 LAMA2 LAMB3 LAMB2 LAMA1 LAMA3 LAMB1 ITGA6 BIOCARTA_AMI_PATHWAY%MSIGDB_C2%BIOCARTA_AMI_PATHWAY BIOCARTA_AMI_PATHWAY F7 PROC F2 F2R COL4A2 COL4A1 COL4A4 COL4A3 AHSP PROS1 PLAT COL4A6 F10 COL4A5 SERPINC1 FGB FGA PLG FGG TFPI PID_TCR_CALCIUM_PATHWAY%MSIGDB_C2%PID_TCR_CALCIUM_PATHWAY PID_TCR_CALCIUM_PATHWAY RCAN1 IL2 IL2RA CD40LG FASLG IFNG AKAP5 PTGS2 IL4 CHP1 BATF3 NFATC2 PRKACA IL3 RCAN2 NFATC1 CABIN1 FKBP1A PPP3CA PPP3CB FOS CREM POU2F1 PPP3R1 CSF2 JUN NFATC3 JUNB FOSL1 BIOCARTA_CACAM_PATHWAY%MSIGDB_C2%BIOCARTA_CACAM_PATHWAY BIOCARTA_CACAM_PATHWAY CAMK1 CAMK1G CAMKK1 CAMKK2 CALM3 CALM1 CALM2 CAMK2D CAMK2A CAMK4 CAMK2G CAMK2B CREB1 PID_ERA_GENOMIC_PATHWAY%MSIGDB_C2%PID_ERA_GENOMIC_PATHWAY PID_ERA_GENOMIC_PATHWAY NR0B2 POU4F1 POU4F2 BRCA1 SOD1 EP300 HDAC4 SMAD4 CD82 SET ANP32A CHUK C3 HDAC1 NR0B1 DDX54 ESR2 UBA3 COL18A1 NCOR2 MTA1 CCND1 JUN ESR1 AXIN2 KLRC3 STAT5A CTSD NRIP1 NCOA1 NCOA2 MED1 NCOR1 NCOA3 CALCOCO1 MPG PCNA SRA1 PHB2 DDX17 PDIA2 DSCAM LMO4 AP1B1 SAFB LCOR TRIM59 CEBPB TFF1 PGR NEDD8 NCOA7 PRDM15 UBE2M MYC ATP5J HSF2 PRL NDUFV3 APBB1 XBP1 ABCA3 GREB1 EBAG9 BIOCARTA_CD40_PATHWAY%MSIGDB_C2%BIOCARTA_CD40_PATHWAY BIOCARTA_CD40_PATHWAY CD40 NFKB1 MAP3K14 TRAF6 CD40LG TRAF3 IKBKB TNFAIP3 NFKBIA RELA IKBKAP IKBKG MAP3K1 DUSP1 CHUK ST_STAT3_PATHWAY%MSIGDB_C2%ST_STAT3_PATHWAY ST_STAT3_PATHWAY IL6 REG1A JAK2 STAT3 JAK3 PTPRU SRC JAK1 PIAS3 IL6R CISH PID_ATR_PATHWAY%MSIGDB_C2%PID_ATR_PATHWAY PID_ATR_PATHWAY YWHAB CDC6 CLSPN BRCA2 PPP2R1A CHEK1 CDK2 MDM2 NBN ATRIP YWHAZ PPP2CA RFC5 RFC3 RFC4 PPP2R2B MCM7 TOPBP1 FBXW11 RFC2 SMARCAL1 CEP164 TIPIN RPA1 CDC25A MCM2 RPA2 HUS1 CCNA2 TIMELESS PLK1 CDC25C FANCD2 SSPO RAD17 RAD1 ATR RAD9A RAD51 ST_TYPE_I_INTERFERON_PATHWAY%MSIGDB_C2%ST_TYPE_I_INTERFERON_PATHWAY ST_TYPE_I_INTERFERON_PATHWAY STAT1 REG1A IFNAR1 STAT2 IRF9 IFNB1 TYK2 PTPRU JAK1 BIOCARTA_AGPCR_PATHWAY%MSIGDB_C2%BIOCARTA_AGPCR_PATHWAY BIOCARTA_AGPCR_PATHWAY ARRB1 GNGT1 GNB1 PRKAR1B PRKAR2B PRKAR1A PRKCB PRKACG PRKAR2A PRKCA GNAS GRK4 PRKACB PID_AVB3_INTEGRIN_PATHWAY%MSIGDB_C2%PID_AVB3_INTEGRIN_PATHWAY PID_AVB3_INTEGRIN_PATHWAY PTPN11 RHOA TGFBR2 VTN RPS6KB1 PIK3CA CDKN1B IGF1R CSF1R CASP8 EDIL3 COL16A1 PIK3C2A ADGRA2 COL13A1 COL14A1 PI4KA COL11A1 PI4KB COL12A1 KDR COL11A2 COL10A1 ROCK1 PXN ANGPTL3 SRC ITGB3 COL2A1 COL5A1 F11R COL7A1 IRS1 MAPK1 COL5A2 COL9A1 COL8A2 COL15A1 COL8A1 COL9A3 ITGAV COL9A2 TLN1 VEGFA COL1A1 ILK COL4A1 MFGE8 COL4A4 COL6A2 VCL COL6A1 CBL COL4A3 COL4A6 COL6A3 COL4A5 IGF1 FGF2 PTK2B SDC1 COL3A1 COL1A2 FN1 BCAR1 PTK2 PIK3R1 SPP1 CSF1 AKT1 RAC1 MAPK3 HSP90AA1 VAV3 COL17A1 PID_EPHA2_FWD_PATHWAY%MSIGDB_C2%PID_EPHA2_FWD_PATHWAY PID_EPHA2_FWD_PATHWAY RHOA TIAM1 PIK3CA BCAR1 GRB2 ACP1 EPHA2 SRC PTK2 SHC1 PIK3R1 PAK1 INPPL1 CBL ARHGAP35 RAC1 EFNA1 VAV3 VAV2 BIOCARTA_PARKIN_PATHWAY%MSIGDB_C2%BIOCARTA_PARKIN_PATHWAY BIOCARTA_PARKIN_PATHWAY UBE2G1 SNCAIP UBE2L6 UBE2G2 SEPT5 PARK2 SUMO1 UBE2L3 UBE2F GPR37 SNCA UBE2E2 BIOCARTA_VITCB_PATHWAY%MSIGDB_C2%BIOCARTA_VITCB_PATHWAY BIOCARTA_VITCB_PATHWAY COL4A2 COL4A1 COL4A4 SLC2A1 COL4A3 COL4A6 COL4A5 SLC23A2 SLC23A1 SLC2A3 P4HB PID_INSULIN_PATHWAY%MSIGDB_C2%PID_INSULIN_PATHWAY PID_INSULIN_PATHWAY PTPN11 RAPGEF1 EXOC6 SH2B2 PDPK1 EXOC5 EXOC2 CRK INPP5D EXOC1 RPS6KB1 PIK3CA GRB14 HRAS GRB2 SOS1 INS PTPRA PARD6A CBL NCK2 GRB10 PRKCI F2RL2 INSR TRIP10 SHC1 SORBS1 RHOQ PIK3R1 FOXO3 EXOC7 PRKCZ PTPN1 IRS1 DOK1 NCK1 AKT2 EIF4EBP1 AKT1 CAV1 EXOC4 RASA1 EXOC3 SGK1 PID_IL8_CXCR1_PATHWAY%MSIGDB_C2%PID_IL8_CXCR1_PATHWAY PID_IL8_CXCR1_PATHWAY ARRB1 PDPK1 GNB1 CXCR1 FGR HCK PLD1 RAB5A PRKCG PRKCE CBL PLCB3 PLCB1 PIK3CG PLCB2 PRKCB PRKCA GNAI2 PIK3R6 GNA14 GNA15 GNG2 ADRBK1 CXCL8 ARRB2 AKT1 DNM1 LYN ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS%MSIGDB_C2%ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS PTPN11 FRS2 PIK3CA ELK1 OPN1LW EGR2 TUBA1A EGR4 CRKL BRAF PIK3C2G TH EGR3 ATF1 CREB3 MAP2K7 CREB5 MAP2K4 MAPK8IP1 CREB1 PIK3CD MAP1B MAPK8 MAPK9 GAST CAMP MAPK10 GNAQ SRC SHC1 PIK3R1 ASAH1 NTRK1 MAPK1 MAPK8IP3 RPS6KA3 DAG1 JUN MAPK8IP2 TERF2IP AKT1 CREBBP RASGRF2 MAPK3 EGR1 PID_BETA_CATENIN_DEG_PATHWAY%MSIGDB_C2%PID_BETA_CATENIN_DEG_PATHWAY PID_BETA_CATENIN_DEG_PATHWAY FZD5 AXIN1 APC CTNNB1 SSPO AXIN2 WNT3A GSK3A CUL1 CSNK1A1 CSNK1D SKP1 GSK3B CSNK1E DVL1 DVL2 DVL3 LRP6 PID_IL3_PATHWAY%MSIGDB_C2%PID_IL3_PATHWAY PID_IL3_PATHWAY PTPN11 GAB2 ID1 INPP5D PIK3CA YWHAG SRP9 GRB2 CNKSR1 STAT5A STAT5B YWHAZ BCL2L1 CISH JAK2 PRKACA IL3 PIM1 HDAC1 SHC1 PIK3R1 CEBPB CSF2RB IL3RA PRKACG OSM PRKACB PID_AP1_PATHWAY%MSIGDB_C2%PID_AP1_PATHWAY PID_AP1_PATHWAY DMTF1 IL2 CDKN1B TIMP1 CCL2 PLAU IL10 EP300 CYR61 TGFB1 IL4 CREB1 HLA-A IL6 IL5 CTNNB1 TP53 ATF3 BCL2L11 DMP1 CXCL8 TCF7L2 CCND1 JUN NFATC3 ESR1 FOSL1 ACTA1 CDKN2A MMP1 SP1 CDK1 ELF1 PTEN IFNG CRTC1 MT2A MAF TH CBFB NTS BAG1 PENK FABP4 ETS1 TRIP6 FOSB MAFG NFATC2 DUSP1 NFATC1 EDN1 FOS AGT COL1A2 NPPA FOSL2 MMP9 GATA2 HIF1A GJA1 CSF2 ATF2 MYC NR3C1 MYB COPS5 EGR1 JUNB JUND PID_HNF3A_PATHWAY%MSIGDB_C2%PID_HNF3A_PATHWAY PID_HNF3A_PATHWAY VTN CDKN1B SP1 BRCA1 INS SOD1 FOXA3 EP300 FOXA2 FOXA1 SFTPD NRIP1 SFTPA1 SERPINA1 NCOA3 FOS KLK3 C4BPB CYP2C18 NKX3-1 GCG NR2F2 PISD AR NFIA POU2F1 NFIB NFIC SCGB1A1 DSCAM AP1B1 SHH CEBPB TFF1 COL18A1 PRDM15 ATP5J JUN NDUFV3 ESR1 XBP1 CREBBP SFTPA2 APOB BIOCARTA_CDMAC_PATHWAY%MSIGDB_C2%BIOCARTA_CDMAC_PATHWAY BIOCARTA_CDMAC_PATHWAY TNF FOS NFKB1 HRAS NFKBIA RELA MAPK1 CUZD1 MYC PLCB1 JUN RAF1 MAP2K1 PRKCB MAPK3 PRKCA PID_ALK1_PATHWAY%MSIGDB_C2%PID_ALK1_PATHWAY PID_ALK1_PATHWAY ID1 TGFBR1 TGFBR2 BMPR2 ACVR1 SMAD1 SMAD5 INHBA SMAD4 TGFB1 GDF2 TGFB3 PPP1CA SMAD7 FKBP1A ENG TLX2 SMAD9 CSNK2B MAPK1 ACVRL1 ARRB2 ACVR2B CAV1 ACVR2A MAPK3 BIOCARTA_MCALPAIN_PATHWAY%MSIGDB_C2%BIOCARTA_MCALPAIN_PATHWAY BIOCARTA_MCALPAIN_PATHWAY TLN1 HRAS EGF CAPN1 ITGB1 EZR CAPNS1 CAPNS2 CAPN2 PXN MYLK CXCR3 PTK2 EGFR ITGA1 MAPK1 PRKAR1B PRKAR2B MYL2 PRKAR1A PRKACG PRKAR2A MAPK3 PRKACB ACTA1 BIOCARTA_TFF_PATHWAY%MSIGDB_C2%BIOCARTA_TFF_PATHWAY BIOCARTA_TFF_PATHWAY RHOA BAD CTNNB1 CYCS PIK3CA HRAS GRB2 SOS1 PTK2 SHC1 PIK3R1 EGFR CASP9 MAPK1 APAF1 PIK3CG ITGB1 AKT1 GH1 MAPK3 GHR BIOCARTA_CARM1_PATHWAY%MSIGDB_C2%BIOCARTA_CARM1_PATHWAY BIOCARTA_CARM1_PATHWAY NCOA3 RXRA CARM1 EP300 PRKAR1B RARA PRKAR2B PRKAR1A CREBBP PRKACG CREB1 PRKAR2A PRKACB BIOCARTA_BCELLSURVIVAL_PATHWAY%MSIGDB_C2%BIOCARTA_BCELLSURVIVAL_PATHWAY BIOCARTA_BCELLSURVIVAL_PATHWAY ZBTB7A CCT4 FOS MTOR PIK3CA XIAP CASP7 PIK3R1 ITGA1 CASP3 PIK3CG ITGB1 AKT1 JUND BIRC5 DPF2 BIOCARTA_PROTEASOME_PATHWAY%MSIGDB_C2%BIOCARTA_PROTEASOME_PATHWAY BIOCARTA_PROTEASOME_PATHWAY PSMD12 PSMD11 PSMD14 RPN2 RPN1 UBE3A PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 UBE2A PSMA5 PSMA6 PSMC6 PSMA4 PSMC3 PSMA1 PSMC4 PSMA2 PSMC2 UBA1 PSMA3 ST_INTEGRIN_SIGNALING_PATHWAY%MSIGDB_C2%ST_INTEGRIN_SIGNALING_PATHWAY ST_INTEGRIN_SIGNALING_PATHWAY ASAP1 PKLR ARHGEF7 ARHGEF6 PIK3CA PAK4 SOS2 VASP TNK2 BRAF GRB2 SOS1 P4HB CSE1L MAP2K4 DOCK1 PIK3CB MAPK9 GRB7 ROCK1 MAPK10 ANGPTL2 SRC ITGA4 ITGA3 PAK1 ITGA2 ITGA1 MAPK1 EPHB2 MAPK8IP3 CDC42 TERF2IP AKT2 ITGA8 AKT3 MRAS CAV1 TLN2 ITGA7 ITGB3BP ARHGAP26 ITGA6 PAK3 CDKN2A TLN1 FYN CRK ITGA9 RALA PLCG1 PTEN ROCK2 ILK ITGA10 ITGA11 ABL1 ZYX RAF1 WAS MAP2K7 MAPK8IP1 PAK2 PAK7 PAK6 MAPK8 ACTR3 MAP3K11 ACTR2 ACTN1 MYLK BCAR1 MYLK2 PTK2 SHC1 ITGA5 RHO ARHGAP35 MAPK8IP2 AKT1 PLCG2 RASGRF2 BIOCARTA_TCAPOPTOSIS_PATHWAY%MSIGDB_C2%BIOCARTA_TCAPOPTOSIS_PATHWAY BIOCARTA_TCAPOPTOSIS_PATHWAY CD28 CD247 FAS CD3G CCR5 CD3E FASLG CD3D CD4 BIOCARTA_TPO_PATHWAY%MSIGDB_C2%BIOCARTA_TPO_PATHWAY BIOCARTA_TPO_PATHWAY THPO STAT1 FOS MPL STAT3 PIK3CA HRAS CSNK2A1 GRB2 PLCG1 SOS1 STAT5A STAT5B SHC1 PIK3R1 JAK2 JUN PIK3CG RAF1 MAP2K1 PRKCB RASA1 MAPK3 PRKCA SA_PROGRAMMED_CELL_DEATH%MSIGDB_C2%SA_PROGRAMMED_CELL_DEATH SA_PROGRAMMED_CELL_DEATH CASP9 BAD APAF1 BAK1 BAX BID BCL10 CES1 BCL2 BCL2L11 CASP8AP2 BCL2L1 SA_G2_AND_M_PHASES%MSIGDB_C2%SA_G2_AND_M_PHASES SA_G2_AND_M_PHASES CDK7 NEK1 CDKN1A CDC25B WEE1 CHEK1 CDK1 CDC25A PID_SHP2_PATHWAY%MSIGDB_C2%PID_SHP2_PATHWAY PID_SHP2_PATHWAY PTPN11 GAB2 STAT1 RHOA IL2 PIK3CA LCK IL2RA HRAS IL2RB IFNGR1 IGF1R GRB2 SOS1 EGF JAK2 ANGPT1 GAB1 PRKACA IL6 KDR PDGFB NRAS MLLT4 IRS1 BDNF KRAS PDGFRB VEGFA NTF4 FRS2 FRS3 NTF3 SDC2 IFNG NTRK3 NOS3 MAP2K2 TEK RAF1 IGF1 GNAI3 GNAI1 NTRK2 NGF IL6ST IL6R LMO4 SHC1 PIK3R1 PAG1 IL2RG EGFR NTRK1 ARHGAP35 MAP2K1 JAK3 JAK1 PID_CERAMIDE_PATHWAY%MSIGDB_C2%PID_CERAMIDE_PATHWAY PID_CERAMIDE_PATHWAY TNF NFKB1 EIF2AK2 RB1 NSMAF SMPD3 PAWR BAX PRKRA BCL2 EGF MAP2K2 BAG4 CASP8 TRADD FADD RIPK1 CTSD RAF1 IGF1 MAP2K4 MADD MAP3K1 BIRC3 CRADD MAPK8 TRAF2 TNFRSF1A BAD CYCS AIFM1 PRKCD NFKBIA ASAH1 PRKCZ KSR1 RELA SPHK2 MAPK1 SMPD1 MYC BID MAP4K4 PDGFA AKT1 MAP2K1 MAPK3 EIF2A PID_PDGFRB_PATHWAY%MSIGDB_C2%PID_PDGFRB_PATHWAY PID_PDGFRB_PATHWAY PTPN11 YWHAB STAT1 YWHAQ PIK3CA PPP2R1A LCK HRAS YWHAG ARAP1 GRB2 YWHAH SOS1 RAB5A YWHAZ PRKCE PIK3CG GAB1 MAP2K4 GRB10 WASL SRC ITGB3 PDGFB PAK1 IQGAP1 NRAS MLLT4 SFN MAPK1 RAP1B RPS6KA3 RAP1A JUN NCK1 ITGAV BLK KRAS PDGFRB VAV2 RAPGEF1 YES1 CRK FGR ELK1 HCK STAT5A PTEN STAT5B PRKCA ACTR3 FOS ACTR2 ARPC1B PIN1 ARPC4 ARPC5 USP6NL ARPC2 ARPC3 CYFIP2 NCKAP1 PTPRJ BRK1 KSR1 DOK1 WASF2 YWHAE ABI1 LRP1 RASA1 EPS8 ARHGDIA RHOA BRAF BAIAP2 PPP2CA S1PR1 JAK2 SPHK1 PPP2R2B PTPN2 PIK3CD PIK3R3 PIK3R2 PIK3CB MAPK9 STAT3 MAPK10 LYN FYN RAB4A EIF2AK2 SRF PLCG1 SLA ACTN4 SLC9A3R2 MAP2K2 DOCK4 MYOCD ACTA2 ABL1 PLA2G4A TAGLN SIPA1 CBL RAF1 NCK2 MAP2K7 PIK3R6 PIK3R5 MAPK8 SLC9A3R1 PRKCD BCAR1 SHC1 DNM2 PIK3R1 PAG1 PTPN1 ARHGAP35 MYC CTTN MAP2K1 RAC1 CSK MAPK3 JUND PID_RHODOPSIN_PATHWAY%MSIGDB_C2%PID_RHODOPSIN_PATHWAY PID_RHODOPSIN_PATHWAY RDH5 CNGB1 GNGT1 GNB1 PDE6B LRAT PDE6A SAG RGS9 GNB5 RHO GUCY2D GUCA1B GUCA1A GUCA1C GUCY2F RPE65 PDE6G RDH12 SLC24A1 RGS9BP CNGA1 GNAT1 BIOCARTA_RNA_PATHWAY%MSIGDB_C2%BIOCARTA_RNA_PATHWAY BIOCARTA_RNA_PATHWAY NFKBIA MAP3K14 NFKB1 RELA EIF2AK2 DNAJC3 TP53 EIF2S2 EIF2S1 CHUK BIOCARTA_NO1_PATHWAY%MSIGDB_C2%BIOCARTA_NO1_PATHWAY BIOCARTA_NO1_PATHWAY PRKG1 VEGFA NOS3 FLT4 BDKRB2 CHRNA1 FLT1 KDR CALM3 RYR2 CALM1 CHRM1 CALM2 PDE3B SLC7A1 TNNI1 PRKG2 PDE2A PDE3A KNG1 PRKAR1B PRKAR2B AKT1 PRKAR1A PRKACG CAV1 PRKAR2A HSP90AA1 PRKACB ACTA1 BIOCARTA_NDKDYNAMIN_PATHWAY%MSIGDB_C2%BIOCARTA_NDKDYNAMIN_PATHWAY BIOCARTA_NDKDYNAMIN_PATHWAY PPP3CA PPP3CB PPP3CC CALM3 CALM1 CALM2 NME1-NME2 SYNJ2 NME1 EPN1 BIN1 AMPH DNM1 PICALM AP2A1 EPS15 SYNJ1 AP2M1 PID_FAK_PATHWAY%MSIGDB_C2%PID_FAK_PATHWAY PID_FAK_PATHWAY PTPN21 SH3GL1 ASAP1 KLF8 RHOA ARHGEF7 PIK3CA ELMO1 BRAF GRB2 SOS1 MAP2K4 DOCK1 MAPK9 MMP14 GRB7 PXN WASL SRC PAK1 RRAS MAPK1 MAPK8IP3 CCND1 RAP1B RAP1A JUN NCK1 ITGAV ARHGAP26 ACTA1 RAPGEF1 TLN1 FYN CRK YES1 PLCG1 ROCK2 GIT2 BMX VCL ETS1 RAF1 ITGB1 NCK2 MAPK8 CAPN2 ACTN1 BCAR1 PTK2 PIK3R1 ARHGEF28 ITGA5 ARHGAP35 RAC1 MAP2K1 RASA1 ARHGEF11 ITGB5 PID_TELOMERASE_PATHWAY%MSIGDB_C2%PID_TELOMERASE_PATHWAY PID_TELOMERASE_PATHWAY TERF2 NFKB1 BLM MTOR IL2 RPS6KB1 CDKN1B PINX1 SMG5 SMG6 PARP2 XRCC6 UBE3A TINF2 XRCC5 NBN DKC1 TNKS TERF1 POT1 EGF PIF1 WRN SAP30 ACD PTGES3 ZNFX1 WT1 SIN3B HNRNPC SIN3A IRF1 TGFB1 SAP18 SMAD3 RBBP7 MRE11A HUS1 MXD1 RAD50 HDAC1 RAD1 RAD9A RBBP4 MAPK1 CCND1 JUN TERF2IP ESR1 IFNAR2 SP1 ATM IFNG ABL1 MAX SP3 FOS HDAC2 NR2F2 EGFR TERT YWHAE MYC E2F1 AKT1 MAPK3 NCL HSP90AA1 PID_HIV_NEF_PATHWAY%MSIGDB_C2%PID_HIV_NEF_PATHWAY PID_HIV_NEF_PATHWAY DAXX TNF TRAF1 NFKB1 FAS BCL2 FASLG CASP7 CASP9 BAG4 CASP6 CASP8 TRADD CASP3 FADD CASP2 RIPK1 APAF1 DFFB DFFA CFLAR MAP2K7 CHUK BIRC3 CRADD MAPK8 TRAF2 TNFRSF1A MAP3K14 CYCS NFKBIA CD247 RELA BID MAP3K5 BIOCARTA_HCMV_PATHWAY%MSIGDB_C2%BIOCARTA_HCMV_PATHWAY BIOCARTA_HCMV_PATHWAY NFKB1 RB1 PIK3CA SP1 MAPK14 PIK3R1 MAP2K2 RELA MAPK1 PIK3CG MAP2K6 MAP2K3 AKT1 MAP2K1 CREB1 MAPK3 MAP3K1 PID_RANBP2_PATHWAY%MSIGDB_C2%PID_RANBP2_PATHWAY PID_RANBP2_PATHWAY PIAS2 HDAC4 XPO1 RAN PIAS1 MDM2 UBE2I SUMO1 RANBP2 HDAC1 RANGAP1 BIOCARTA_TNFR2_PATHWAY%MSIGDB_C2%BIOCARTA_TNFR2_PATHWAY BIOCARTA_TNFR2_PATHWAY TRAF2 TRAF1 NFKB1 MAP3K14 TRAF3 IKBKB LTA TNFAIP3 NFKBIA RELA TANK IKBKAP RIPK1 IKBKG TNFRSF1B MAP3K1 DUSP1 CHUK PID_CXCR4_PATHWAY%MSIGDB_C2%PID_CXCR4_PATHWAY PID_CXCR4_PATHWAY PTPN11 STAT1 MTOR PIK3CA LCK PIK3CG RGS1 GRK6 SSH1 RHOB VPS4B VPS4A PXN UBQLN1 CD3G CD3E CD3D SRC CD4 PTPRC PAK1 CD247 GNB2L1 CDC42 RAP1B DNM1 ITGAV BLK RALB GNB1 YES1 CRK FGR HCK RHOC FOXO1 STAT5A PTEN STAT5B HLA-DRA HLA-DRB1 LIMK1 STAT2 HGS PTPN6 ARRB2 CFL1 PDPK1 RHOA JAK2 PIK3CD PIK3R3 PIK3R2 PIK3CB ITCH BAD STAT3 ITGA4 ITGA3 ITGA2 ITGA1 ITGA8 ITGA7 LYN ITGA6 FYN ITGA9 INPP5D ITGA10 ITGA11 PLCB3 PLCB1 ITGB1 PLCB2 GNAZ ARR3 GNAI3 GNAI1 CXCR4 GNAI2 PIK3R6 PIK3R5 GNA13 GNG2 PTK2B GNAO1 ADRBK1 BCAR1 MAPKAP1 MMP9 PTK2 MLST8 RICTOR PIK3R1 PAG1 CXCL12 PRKCZ ITGA5 AKT1 RAC1 CSK VAV1 BIOCARTA_LONGEVITY_PATHWAY%MSIGDB_C2%BIOCARTA_LONGEVITY_PATHWAY BIOCARTA_LONGEVITY_PATHWAY PIK3CA CAT HRAS IGF1R SOD2 SOD1 SHC1 PIK3R1 FOXO3 SOD3 PIK3CG IGF1 AKT1 GH1 GHR BIOCARTA_ACTINY_PATHWAY%MSIGDB_C2%BIOCARTA_ACTINY_PATHWAY BIOCARTA_ACTINY_PATHWAY ACTR3 ACTR2 ARPC1B ARPC1A ARPC4 ARPC5 ARPC2 ARPC3 WASL PSMA7 NCKAP1 NTRK1 ABI2 PIR WASF2 WASF3 WASF1 NCK1 RAC1 ACTA1 PID_PS1_PATHWAY%MSIGDB_C2%PID_PS1_PATHWAY PID_PS1_PATHWAY NEDD4 AXIN1 NKD1 WNT1 APC HNF1A DKK2 CSNK1A1 FBXW11 GSK3B NLK DVL1 NOTCH1 LRP6 FZD1 FOS CTNNB1 DKK1 TAB1 ADAM10 SSPO KREMEN2 HDAC1 CSNK2A1 AES WIF1 PSENEN MAPK1 PSEN1 PPP2R5D CCND1 MYC APH1A JUN CTBP1 DTX1 RBPJ PPARD DLL1 NCSTN FRAT1 APH1B CREBBP MAPK3 MAP3K7 TLE1 BIOCARTA_CXCR4_PATHWAY%MSIGDB_C2%BIOCARTA_CXCR4_PATHWAY BIOCARTA_CXCR4_PATHWAY GNGT1 NFKB1 GNB1 CRK PTK2B PIK3CA GNAQ PXN HRAS BCAR1 PLCG1 PTK2 PIK3R1 CXCL12 PIK3C2G RELA MAPK1 RAF1 MAP2K1 PRKCB GNAI1 MAPK3 CXCR4 PRKCA PID_CMYB_PATHWAY%MSIGDB_C2%PID_CMYB_PATHWAY PID_CMYB_PATHWAY CLTA WNT1 CDKN1A CDKN1B HRAS HES1 BCL2 KIT PIAS3 TRIM28 CSF1R EP300 ETS2 ZFPM1 SIN3A GATA1 BIRC3 GATA3 PIM1 TAB2 TAB1 CEBPA CD4 CCNB1 IQGAP1 NRAS SPI1 CCND1 UBE2I LEF1 CREBBP SLC25A3 KRAS LECT2 YEATS4 CA1 CDKN2A CDK6 TOM1 RAG2 KITLG CD34 SMARCA2 PTCRA H2AFZ PAX5 SND1 SP1 CCNA1 ADORA2B TFEC PRTN3 MAD1L1 ELANE PPID MAT2A HSPA8 ZFHX3 MAF GSTM1 CASP6 ATP2B1 MPO LYZ HIPK2 SKI MYF6 ETS1 NLK MCM4 PTGS2 MYOD1 PPP3CA NCOR1 ANPEP COL1A2 COPA ADA CEBPB CEBPD MYC MYB MAP3K7 CBX4 PID_S1P_S1P2_PATHWAY%MSIGDB_C2%PID_S1P_S1P2_PATHWAY PID_S1P_S1P2_PATHWAY MAPK8 GNA13 GNA15 FOS GNA11 RHOA GNA12 GNAO1 ELK1 GNAQ S1PR2 MAPK14 PAK1 CDH5 IRS1 MAPK1 JUN GNAZ GNAI3 RAC1 GNAI1 MAPK3 GNAI2 GNA14 BIOCARTA_INFLAM_PATHWAY%MSIGDB_C2%BIOCARTA_INFLAM_PATHWAY BIOCARTA_INFLAM_PATHWAY TNF IL2 IFNG IL1A LTA IL10 IL11 IL15 TGFB2 IL13 HLA-DRA TGFB1 HLA-DRB1 IL4 TGFB3 IL3 IL6 IL5 IL7 IFNA1 CD4 CXCL8 IL12B CSF3 IL12A CSF2 CSF1 IFNB1 PDGFA BIOCARTA_IGF1R_PATHWAY%MSIGDB_C2%BIOCARTA_IGF1R_PATHWAY BIOCARTA_IGF1R_PATHWAY BAD PIK3CA HRAS RPS6KA1 IGF1R GRB2 YWHAH SOS1 SHC1 PIK3R1 IRS1 ADCY1 MAPK1 PRKAR1B PRKAR2B RAF1 PRKAR1A AKT1 MAP2K1 PRKACG PRKAR2A MAPK3 PRKACB PID_IL12_STAT4_PATHWAY%MSIGDB_C2%PID_IL12_STAT4_PATHWAY PID_IL12_STAT4_PATHWAY IL2 IL2RA IFNG CD80 IL13 IRF1 HLA-DRA TGFB1 IL18 HLA-DRB1 CD86 PPP3CA MAPK8 MAPK9 PPP3CB PIAS2 FOS STAT3 STAT4 CD3G CD3E IL18R1 CD3D IL18RAP CD4 PPP3R1 CD28 CD247 TBX21 JUN CREBBP ETV5 PRF1 ST_GAQ_PATHWAY%MSIGDB_C2%ST_GAQ_PATHWAY ST_GAQ_PATHWAY ITPR3 NFKB1 CFB PLD1 PLD2 TONSL IKBKG NFKBIL1 PLD3 PHKA2 NFKB2 NFKBIE NFKBIB PIK3CB ADRBK1 GNAQ NFKBIA VN1R1 PITX2 DAG1 AKT2 AKT1 AKT3 ITPR1 ITPKB PDK1 ITPR2 ITPKA PID_SMAD2_3NUCLEAR_PATHWAY%MSIGDB_C2%PID_SMAD2_3NUCLEAR_PATHWAY PID_SMAD2_3NUCLEAR_PATHWAY MEF2C DCP1A CDKN1A SERPINE1 PIAS3 SAP30 IL10 EP300 SKIL SIN3B PIAS4 TCF3 SIN3A SMAD2 SMAD4 CDK4 TFE3 SAP18 SMAD3 RBBP7 CREB1 SMAD7 KAT2B KAT2A GATA3 RBL1 TFDP1 IL5 ATF3 HDAC1 RBBP4 E2F4 E2F5 JUN CTBP1 IFNB1 VDR ESR1 CREBBP FOXO4 LAMC1 SP1 CDK2 NKX2-5 FOXO1 HSPA8 CBFB SKI MAX HNF4A ZBTB17 SP3 NCOA1 NCOA2 MYOD1 NCOR1 FOS HDAC2 COL1A2 AR RUNX1 FOXO3 CEBPB CITED1 MED15 ATF2 MYC SNIP1 NR3C1 TGIF1 RUNX2 TGIF2 AKT1 FOXH1 RUNX3 IRF7 DLX1 GSC FOXG1 ITGB5 CDKN2B PID_INTEGRIN_CS_PATHWAY%MSIGDB_C2%PID_INTEGRIN_CS_PATHWAY PID_INTEGRIN_CS_PATHWAY ITGB4 ITGA9 ITGAE ITGB8 ITGB7 ITGA10 ITGB2 ITGB6 ITGA11 ITGA2B ITGB1 ITGAX ITGAD ITGAM ITGAL ITGB3 ITGA4 ITGA3 ITGA2 ITGA5 ITGA1 ITGA8 ITGAV ITGA7 ITGB5 ITGA6 BIOCARTA_P53HYPOXIA_PATHWAY%MSIGDB_C2%BIOCARTA_P53HYPOXIA_PATHWAY BIOCARTA_P53HYPOXIA_PATHWAY MAPK8 FHL2 TAF1 IGFBP3 CDKN1A NQO1 MDM2 BAX TP53 ABCB1 ATM HIF1A EP300 CSNK1A1 CSNK1D HSPA1A GADD45A AKT1 RPA1 TAF1L HIC1 HSP90AA1 NFKBIB ST_INTERLEUKIN_4_PATHWAY%MSIGDB_C2%ST_INTERLEUKIN_4_PATHWAY ST_INTERLEUKIN_4_PATHWAY NR0B2 IARS INPP5D STAT6 RPS6KB1 PIK3CA SOS2 GRB2 PPP1R13B SOS1 CISH JAK2 IL4 TYK2 SERPINA4 SRC SHC1 IL2RG PI3 IL13RA1 IL4R AKT2 AKT1 AKT3 JAK3 JAK1 PID_HEDGEHOG_GLI_PATHWAY%MSIGDB_C2%PID_HEDGEHOG_GLI_PATHWAY PID_HEDGEHOG_GLI_PATHWAY GNB1 GLI2 SAP30 SMO FOXA2 SIN3B PIAS1 SIN3A CSNK1A1 FBXW11 CSNK1D GSK3B IFT172 SAP18 GLI1 RBBP7 CSNK1E GNAZ GLI3 GNAI3 KIF3A GNAI1 STK36 SUFU PRKACA GNAI2 RAB23 SPOP MTSS1 IFT88 GNG2 GNAO1 CSNK1G3 HDAC2 PRKCD SSPO CSNK1G2 LGALS3 CSNK1G1 HDAC1 RBBP4 SHH XPO1 PTCH1 ARRB2 AKT1 CREBBP MAP2K1 PID_REG_GR_PATHWAY%MSIGDB_C2%PID_REG_GR_PATHWAY PID_REG_GR_PATHWAY STAT1 NFKB1 IL2 CDKN1A BAX YWHAH EP300 IL13 IRF1 IL4 CREB1 PRKACA SMARCC1 FGG GATA3 MAPK9 IL6 IL5 MAPK10 TP53 POU2F1 HDAC1 VIPR1 CSN2 SUV420H1 MAPK14 SUMO2 POU1F1 SMARCC2 FKBP4 SPI1 CXCL8 FKBP5 TBX21 SMARCD1 MAPK1 SFN TSG101 CGA NR4A1 PCK2 JUN PBX1 KRT17 CREBBP SMARCA4 MAPK11 MMP1 MDM2 IFNG STAT5A STAT5B GSK3B BGLAP NCOA1 NFATC1 CDK5 NCOA2 MAPK8 FOS CDK5R1 KRT5 HDAC2 SELE NR1I3 ICAM1 KRT14 AFP PPP5C RELA CSF2 TBP NR3C1 PRL POMC AKT1 PRKACG MAPK3 EGR1 HSP90AA1 SGK1 PRKACB BIOCARTA_G1_PATHWAY%MSIGDB_C2%BIOCARTA_G1_PATHWAY BIOCARTA_G1_PATHWAY CDKN2A CDK6 DHFR RB1 CDKN1A CDKN1B CCNA1 CDK2 CDK1 ATM ABL1 TGFB2 GSK3B SMAD4 CDK4 TGFB1 SMAD3 SKP2 TGFB3 CDC25A TFDP1 CCNE1 TP53 HDAC1 ATR CCND1 E2F1 CDKN2B SA_CASPASE_CASCADE%MSIGDB_C2%SA_CASPASE_CASCADE SA_CASPASE_CASCADE GZMB SREBF2 SCAP FAS XIAP FASLG CASP7 CASP9 CASP8 CASP10 CASP3 SREBF1 APAF1 DFFB DFFA PARP1 PRF1 BIRC2 BIRC3 PID_RAC1_PATHWAY%MSIGDB_C2%PID_RAC1_PATHWAY PID_RAC1_PATHWAY IQGAP3 NOX1 BAIAP2 MAP2K6 MAP2K3 MAP2K4 MAP3K1 MAPK9 CTNNB1 STAT3 MAPK14 PAK1 IQGAP1 ABI2 WASF1 JUN CDH1 CTNNA1 PIP5K1C PIP5K1B CRK NCF1 NCF2 STAT5A CYBB CYBA PIP5K1A NOXO1 NOXA1 PLCB2 MAP2K7 PAK2 MAPK8 ACTR3 LIMK1 MAP3K11 ACTR2 ARPC1B ARPC4 ARPC5 ARPC2 ARPC3 BCAR1 CYFIP2 RACGAP1 NCKAP1 BRK1 ARHGAP5 WASF2 ATF2 ABI1 RAC1 ARHGDIA CFL1 BIOCARTA_KERATINOCYTE_PATHWAY%MSIGDB_C2%BIOCARTA_KERATINOCYTE_PATHWAY BIOCARTA_KERATINOCYTE_PATHWAY DAXX TNF NFKB1 SP1 HRAS FAS BCL2 EGF FASLG PRKCG PPP2CA PRKCH PRKCE ETS2 PRKCQ ETS1 RIPK1 HOXA7 RAF1 MAP2K6 MAP2K7 MAP2K3 TNFRSF1B MAP2K4 PRKCB MAP3K1 PRKCA CHUK MAPK8 TRAF2 TNFRSF1A FOS MAP3K14 PRKCD CEBPA MAPK14 MAPK13 IKBKB NFKBIA EGFR RELA MAPK1 JUN MAP2K1 MAPK3 MAP3K5 BIOCARTA_CARM_ER_PATHWAY%MSIGDB_C2%BIOCARTA_CARM_ER_PATHWAY BIOCARTA_CARM_ER_PATHWAY MEF2C HDAC10 HDAC11 CARM1 BRCA1 HDAC5 HDAC3 EP300 HDAC4 HDAC8 PELP1 HDAC9 HDAC6 NRIP1 HIST2H3C PPARGC1A MED1 HDAC2 SRA1 PHB2 HDAC1 NR0B1 GRIP1 HDAC7 GTF2A1 GTF2F1 GTF2E1 NCOR2 TBP ERCC3 CCND1 POLR2A ESR1 CREBBP SPEN BIOCARTA_AKAP13_PATHWAY%MSIGDB_C2%BIOCARTA_AKAP13_PATHWAY BIOCARTA_AKAP13_PATHWAY GNA13 GNA12 RHOA PRKAR2B AKAP13 PRKAG1 PRKACG PRKAR2A LPAR1 LPAR2 LPAR3 PRKACB PID_MAPK_TRK_PATHWAY%MSIGDB_C2%PID_MAPK_TRK_PATHWAY PID_MAPK_TRK_PATHWAY MEF2C MAPKAPK2 SRF ELK1 NTF3 HRAS BRAF RIT1 EHD4 RIT2 TRPV1 RAF1 MAP2K6 MAP2K3 RPS6KA5 CREB1 MAPK7 CDK5 RUSC1 FOS CDK5R1 PRKCD RPS6KA1 MAP2K5 MAPK14 NRAS MAPK1 MAP3K2 RAP1B RAP1A MAP2K1 MAPK3 EGR1 KRAS BIOCARTA_NO2IL12_PATHWAY%MSIGDB_C2%BIOCARTA_NO2IL12_PATHWAY BIOCARTA_NO2IL12_PATHWAY STAT4 TYK2 IL12RB1 CD3G CCR5 CD3E CXCR3 CD3D IFNG IL12RB2 CD2 CD4 CD247 JAK2 IL12B NOS2 IL12A PID_LYSOPHOSPHOLIPID_PATHWAY%MSIGDB_C2%PID_LYSOPHOSPHOLIPID_PATHWAY PID_LYSOPHOSPHOLIPID_PATHWAY NFKB1 RHOA TIAM1 HRAS PRKCE ADCY4 ADCY3 ADCY2 LPAR4 CASP3 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 ADCY9 GAB1 PIK3CB IL6 PXN SRC HBEGF NFKBIA CXCL8 JUN LYN GNB1 CRK PLCG1 PLD2 SLC9A3R2 PLCB3 GSK3B TRIP6 GNAZ GNAI3 PRKD1 LPAR1 GNAI1 LPAR2 ARHGEF1 LPAR3 GNAI2 MMP2 GNA14 MAPT GNA13 GNA15 FOS GNA11 GNG2 GNA12 ADRA1B PTK2B MAGI3 GNAO1 PRKCD GNAQ BCAR1 MMP9 PTK2 PIK3R1 EGFR RELA AKT1 RAC1 PID_P38_MKK3_6PATHWAY%MSIGDB_C2%PID_P38_MKK3_6PATHWAY PID_P38_MKK3_6PATHWAY MAP3K3 MAPK11 TRAF6 CCM2 ATM MAP3K6 MAP3K4 MAP2K6 MAP2K3 MAP3K10 MAP3K1 TRAF2 TAB2 TAB1 TAOK3 TAOK1 TAOK2 MAPK14 GADD45B GADD45G GADD45A CAMK2B RAC1 TXN MAP3K7 MAP3K5 BIOCARTA_EIF2_PATHWAY%MSIGDB_C2%BIOCARTA_EIF2_PATHWAY BIOCARTA_EIF2_PATHWAY EIF2AK3 EIF2AK4 EIF2AK2 GSK3B EIF2B5 EIF2S2 EIF2S1 PPP1CA EIF5 EIF2S3 EIF2AK1 BIOCARTA_MITOCHONDRIA_PATHWAY%MSIGDB_C2%BIOCARTA_MITOCHONDRIA_PATHWAY BIOCARTA_MITOCHONDRIA_PATHWAY CYCS AIFM1 BAX BCL2 XIAP CASP7 BCL2L1 CASP9 CASP6 CASP8 CASP3 ENDOG APAF1 BIK BAK1 DFFB BID DFFA BIRC2 BIRC3 DIABLO ST_INTERFERON_GAMMA_PATHWAY%MSIGDB_C2%ST_INTERFERON_GAMMA_PATHWAY ST_INTERFERON_GAMMA_PATHWAY STAT1 REG1A JAK2 PLA2G2A IFNGR1 ELP2 PTPRU IFNG JAK1 CISH PID_IL2_1PATHWAY%MSIGDB_C2%PID_IL2_1PATHWAY PID_IL2_1PATHWAY PTPN11 GAB2 STAT1 RHOA MAPKAPK2 IL2 PIK3CA LCK IL2RA HRAS IL2RB BCL2 GRB2 SOS1 CISH PRKCE IKZF3 MAPK9 STAT3 SYK MAPK14 NRAS IRS1 MAPK1 IRS2 JUN KRAS FYN SOCS3 SOCS1 MAPK11 CDK2 DOK2 IFNG STAT5A STAT5B MAP2K2 RAF1 PRKCB MAPK8 FOS PTK2B SHC1 PIK3R1 IL2RG PPP2R5D MYC MAP2K1 JAK3 RASA1 STAM2 MAPK3 JAK1 SOCS2 STAM PID_RHOA_PATHWAY%MSIGDB_C2%PID_RHOA_PATHWAY PID_RHOA_PATHWAY TLN1 SCAI MKL1 RHOA MSN CIT PKN2 CDKN1B SRF PPP1R12A LIMK2 PLD1 PLD2 ROCK2 PTEN PIP5K1A PKN1 PARD6A CYR61 SLC9A3 VCL ITGB1 MAP2K6 MAP2K3 RDX MAP2K4 EZR SLC9A1 MAPK8 LIMK1 FOS F2RL2 ROCK1 MAPK12 PRKCZ SH3GL2 CDC42 ATF2 JUN DIAPH1 MYL2 PIP5K1C CFL1 PIP5K1B ACTA1 PID_BARD1_PATHWAY%MSIGDB_C2%PID_BARD1_PATHWAY PID_BARD1_PATHWAY UBE2D3 CDK2 XRCC6 BRCA1 UBE2L3 XRCC5 ATM NBN CSTF1 BARD1 EWSR1 FANCL TOPBP1 FANCA MRE11A FANCC FANCE PRKDC FANCG FANCF RAD50 CCNE1 FANCD2 PCNA TP53 ATR RBBP8 NPM1 RAD51 BIOCARTA_NFAT_PATHWAY%MSIGDB_C2%BIOCARTA_NFAT_PATHWAY BIOCARTA_NFAT_PATHWAY MEF2C MYH2 RPS6KB1 PIK3CA HRAS HAND2 HAND1 CSNK1A1 CALR PIK3CG FKBP1A ELSPBP1 NFATC4 MAPK14 HBEGF CAMK4 MAPK1 CTF1 NFATC3 CREBBP LIF ACTA1 GATA4 NKX2-5 GSK3B RAF1 IGF1 NFATC2 NFATC1 PPP3CA EDN1 MAPK8 CAMK1 FGF2 PPP3CB CAMK1G PPP3CC CALM3 AGT CALM1 CALM2 NPPA F2 PIK3R1 PRKAR1B PRKAR2B AKT1 PRKAR1A PRKACG MAP2K1 PRKAR2A MAPK3 PRKACB PID_SYNDECAN_2_PATHWAY%MSIGDB_C2%PID_SYNDECAN_2_PATHWAY PID_SYNDECAN_2_PATHWAY RHOA NF1 BAX HRAS SDC2 CASP3 TGFB1 EPB41 ITGB1 CAV2 TRAPPC4 TNFRSF13B EZR PRKACA MMP2 MAPK8 SDCBP PRKCD FN1 SRC KNG1 ITGA2 ITGA5 CXCL8 MAPK1 CSF2 EPHB2 CASK GNB2L1 LAMA1 LAMA3 MAPK3 RASA1 BIOCARTA_DNAFRAGMENT_PATHWAY%MSIGDB_C2%BIOCARTA_DNAFRAGMENT_PATHWAY BIOCARTA_DNAFRAGMENT_PATHWAY GZMB CASP3 ENDOG DFFB DFFA TOP2A HMGB1 HMGB2 TOP2B CASP7 BIOCARTA_TNFR1_PATHWAY%MSIGDB_C2%BIOCARTA_TNFR1_PATHWAY BIOCARTA_TNFR1_PATHWAY TNF RB1 LMNB2 LMNB1 BAG4 CASP8 TRADD CASP3 FADD ARHGDIB CASP2 RIPK1 DFFB DFFA PARP1 MAP2K4 MADD PAK2 SPTAN1 MAP3K1 CRADD MAPK8 LMNA TRAF2 TNFRSF1A PRKDC PAK1 JUN MAP3K7 BIOCARTA_RANMS_PATHWAY%MSIGDB_C2%BIOCARTA_RANMS_PATHWAY BIOCARTA_RANMS_PATHWAY KIF15 RAN RCC1 KPNB1 RANBP1 AURKA RANGAP1 TPX2 NUMA1 KPNA2 PID_P75_NTR_PATHWAY%MSIGDB_C2%PID_P75_NTR_PATHWAY PID_P75_NTR_PATHWAY RHOA SQSTM1 PIK3CA XIAP APP CASP3 APAF1 IKBKG BIRC2 CHUK BIRC3 PRKCI MAPK9 PRDM4 OMG MAG BAD NGFRAP1 RHOB RTN4R MAGEH1 ZNF274 MAPK10 TP53 BEX1 RTN4 BCL2L11 NDNL2 NDN LINGO1 SORT1 IKBKB BDNF NTF4 MMP7 RIPK2 MMP3 TRAF6 RHOC NTF3 MAGED1 CASP9 CASP6 IRAK1 MYD88 PLG DIABLO MAPK8 CYCS NGFR NGF FURIN SHC1 PIK3R1 ADAM17 PRKCZ PSENEN NTRK1 PSEN1 YWHAE APH1A E2F1 AKT1 NCSTN RAC1 APH1B SMPD2 ARHGDIA PRKACB PID_ANTHRAX_PATHWAY%MSIGDB_C2%PID_ANTHRAX_PATHWAY PID_ANTHRAX_PATHWAY TNF VCAM1 MAP2K2 MAPK1 PGR CASP1 IL18 MAP2K6 MAP2K3 MAP2K7 MAP2K4 MAP2K1 IL1B ANTXR2 MAPK3 ANTXR1 NLRP1 PID_ECADHERIN_NASCENT_AJ_PATHWAY%MSIGDB_C2%PID_ECADHERIN_NASCENT_AJ_PATHWAY PID_ECADHERIN_NASCENT_AJ_PATHWAY RAPGEF1 AP1M1 ENAH RHOA KLHL20 TIAM1 CRK PIK3CA ARF6 ITGAE DLG1 ITGB7 TJP1 CTNNB1 CTNND1 CSNK2A1 SRC CSNK2A2 CYFIP2 NCKAP1 PIK3R1 IQGAP1 CSNK2B MLLT4 WASF2 JUP CDC42 RAP1B CCND1 NME1 RAP1A CTTN CDH1 ABI1 CTNNA1 AKT1 RAC1 PIP5K1C VAV2 BIOCARTA_IL5_PATHWAY%MSIGDB_C2%BIOCARTA_IL5_PATHWAY BIOCARTA_IL5_PATHWAY IL6 IL5 HLA-DRA HLA-DRB1 CCR3 CCL11 IL4 IL1B IL5RA CD4 PID_UPA_UPAR_PATHWAY%MSIGDB_C2%PID_UPA_UPAR_PATHWAY PID_UPA_UPAR_PATHWAY PLAUR CRK VTN PDGFD FPR1 KLK4 FPR3 MMP3 SERPINE1 FPR2 CTSG CTRC ELANE PLAU ITGB2 VLDLR TGFB1 ITGB1 DOCK1 FGB FGA PLG FGG MMP12 HGF MMP13 FN1 BCAR1 ITGAM MMP9 SRC ITGB3 ITGA3 EGFR ITGA5 GPLD1 LRP1 ITGAV RAC1 NCL PDGFRB ITGB5 PID_VEGFR1_2_PATHWAY%MSIGDB_C2%PID_VEGFR1_2_PATHWAY PID_VEGFR1_2_PATHWAY PTPN11 NEDD4 PDPK1 RHOA MAPKAPK2 VTN PIK3CA BRAF GRB2 FBXW11 PTPN2 MAP2K6 MAP2K3 GAB1 PRKACA GRB10 FLT1 PRKAA1 PRKAA2 CTNNB1 KDR PRKAB1 ROCK1 PXN SRC ITGB3 MAPK14 IQGAP1 MAPK1 CDC42 PRKAG1 NCK1 CTNNA1 ITGAV CAV1 FYN VEGFA ARF1 MAPK11 SHB PLCG1 NOS3 HSP90AB1 MAP2K2 MYOF FES AKAP1 VCL CBL RAF1 NCK2 PRKCB PAK2 PRKCA CAMKK2 PTK2B PRKCD SH2D2A PTK2 DNM2 PIK3R1 PTPRJ CDH5 HGS PTPN6 AKT1 MAP2K1 MAPK3 HSP90AA1 PID_ARF6_DOWNSTREAM_PATHWAY%MSIGDB_C2%PID_ARF6_DOWNSTREAM_PATHWAY PID_ARF6_DOWNSTREAM_PATHWAY PLAUR RHOA TIAM1 ARF1 ARF6 RAB11A PLD1 PLD2 KALRN PIP5K1A MAPK1 RAB11FIP3 NME1 RAC1 MAPK3 BIOCARTA_GSK3_PATHWAY%MSIGDB_C2%BIOCARTA_GSK3_PATHWAY BIOCARTA_GSK3_PATHWAY TIRAP PDPK1 AXIN1 NFKB1 WNT1 EIF2AK2 APC PIK3CA PPP2CA IRAK1 GSK3B LBP DVL1 TOLLIP GNAI1 MYD88 FZD1 CTNNB1 TLR4 PIK3R1 GJA1 RELA CCND1 LEF1 AKT1 LY96 CD14 BIOCARTA_EGFR_SMRTE_PATHWAY%MSIGDB_C2%BIOCARTA_EGFR_SMRTE_PATHWAY BIOCARTA_EGFR_SMRTE_PATHWAY EGFR RXRA NCOR2 RARA ZBTB16 MAP2K1 EGF MAP3K1 THRB MAPK14 THRA BIOCARTA_PITX2_PATHWAY%MSIGDB_C2%BIOCARTA_PITX2_PATHWAY BIOCARTA_PITX2_PATHWAY MED1 AXIN1 WNT1 APC CTNNB1 TRRAP HDAC1 EP300 PITX2 GSK3B DVL1 LEF1 CREBBP LDB1 FZD1 BIOCARTA_IL17_PATHWAY%MSIGDB_C2%BIOCARTA_IL17_PATHWAY BIOCARTA_IL17_PATHWAY CD8A IL6 KITLG CD34 CD3G IL17A CD3E CD3D CD2 CD4 CD247 CXCL8 CSF3 IL3 CD58 BIOCARTA_FMLP_PATHWAY%MSIGDB_C2%BIOCARTA_FMLP_PATHWAY BIOCARTA_FMLP_PATHWAY GNGT1 NFKB1 GNB1 FPR1 ELK1 HRAS NCF2 PIK3C2G MAP2K2 PLCB1 RAF1 MAP2K6 MAP2K3 NFATC2 MAP3K1 NFATC1 NCF1C PPP3CA CAMK1 GNA15 PPP3CB CAMK1G PPP3CC NFATC4 CALM3 CALM1 CALM2 MAPK14 PAK1 NFKBIA RELA MAPK1 NFATC3 RAC1 MAP2K1 MAPK3 BIOCARTA_PS1_PATHWAY%MSIGDB_C2%BIOCARTA_PS1_PATHWAY BIOCARTA_PS1_PATHWAY AXIN1 WNT1 APC CTNNB1 HNF1A ADAM17 GSK3B PSEN1 RBPJ DVL1 DLL1 NOTCH1 BTRC FZD1 SA_TRKA_RECEPTOR%MSIGDB_C2%SA_TRKA_RECEPTOR SA_TRKA_RECEPTOR RHOA CDKN1A PIK3CA ELK1 NGFR HRAS NGF GRB2 SOS1 SHC1 MAP2K2 NTRK1 AKT2 AKT1 MAP2K1 AKT3 PIK3CD ST_GA12_PATHWAY%MSIGDB_C2%ST_GA12_PATHWAY ST_GA12_PATHWAY MYEF2 MAPK8 BTK F2RL3 F2RL1 CFB F2RL2 F2 PLD1 PLD2 SRC PTK2 MAP2K5 MAPK1 EPHB2 JUN RAF1 PLD3 VAV1 RASAL1 MAPK7 NR4A3 DLG4 PID_VEGF_VEGFR_PATHWAY%MSIGDB_C2%PID_VEGF_VEGFR_PATHWAY PID_VEGF_VEGFR_PATHWAY FLT4 VEGFA FLT1 KDR FIGF PGF NRP1 VEGFB NRP2 VEGFC BIOCARTA_MPR_PATHWAY%MSIGDB_C2%BIOCARTA_MPR_PATHWAY BIOCARTA_MPR_PATHWAY GNGT1 GNB1 HRAS CDK1 ADCY1 GNAI1 ACTR3 ACTR2 ARPC1B PAQR7 CDC25C ARPC1A PAQR5 MYT1 PIN1 ARPC4 ARPC5 ARPC2 ARPC3 RPS6KA1 CAP1 SRC CCNB1 MAPK1 PGR PRKAR1B PRKAR2B PRKAR1A PRKACG PRKAR2A MAPK3 GNAS PRKACB ACTA1 BIOCARTA_RAC1_PATHWAY%MSIGDB_C2%BIOCARTA_RAC1_PATHWAY BIOCARTA_RAC1_PATHWAY LIMK1 ARFIP2 CDK5R1 PDGFRA RPS6KB1 PIK3CA MYLK PLD1 NCF2 TRIO PIK3R1 PAK1 PPP1R12B WASF1 RALBP1 PIK3CG MYL2 CHN1 RAC1 VAV1 MAP3K1 CDK5 CFL1 PID_SYNDECAN_1_PATHWAY%MSIGDB_C2%PID_SYNDECAN_1_PATHWAY PID_SYNDECAN_1_PATHWAY MMP7 MMP1 COL1A1 HPSE COL4A1 COL4A4 COL6A2 COL6A1 COL4A3 TGFB1 COL4A6 COL6A3 COL4A5 PRKACA COL16A1 HGF COL13A1 COL14A1 SDCBP COL11A1 COL12A1 CCL5 SDC1 COL11A2 COL3A1 MET COL1A2 BSG COL10A1 PPIB MMP9 COL2A1 COL5A1 COL7A1 MAPK1 COL5A2 CASK COL9A1 LAMA5 COL15A1 COL8A2 COL8A1 COL9A3 COL9A2 MAPK3 COL17A1 BIOCARTA_D4GDI_PATHWAY%MSIGDB_C2%BIOCARTA_D4GDI_PATHWAY BIOCARTA_D4GDI_PATHWAY GZMB CYCS CASP9 CASP8 CASP10 ARHGAP5 CASP3 ARHGDIB CASP1 APAF1 JUN PARP1 PRF1 PID_IL6_7_PATHWAY%MSIGDB_C2%PID_IL6_7_PATHWAY PID_IL6_7_PATHWAY PTPN11 STAT1 GAB2 SOCS3 MAPK11 PIK3CA TIMP1 HCK GRB2 FOXO1 SOS1 A2M PIAS3 BCL2L1 JAK2 PIAS1 IRF1 LBP MAP2K6 GAB1 MAP2K4 FGG IL6 FOS STAT3 PRKCD TYK2 CRP HSP90B1 IL6ST IL6R LMO4 MAPK14 PTPRE PIK3R1 CEBPB TNFSF11 CEBPD MYC MITF JUN MCL1 AKT1 RAC1 VAV1 JUNB JAK1 PID_ATF2_PATHWAY%MSIGDB_C2%PID_ATF2_PATHWAY PID_ATF2_PATHWAY DDIT3 RB1 NF1 BRCA1 HES1 BCL2 BCL2L1 PLAU EP300 TGFB2 CDK4 PPARGC1A CREB1 CCNA2 MAPK9 IL6 ATF3 POU2F1 COL24A1 MAPK14 CXCL8 MAPK1 CCND1 JUN GADD45A ARG1 ESR1 DUSP10 SOCS3 DUSP8 PDGFRA IL23A MAPK11 IFNG INS TH CBFB KAT5 RUVBL2 DUSP5 DUSP1 PRKCA MMP2 CUL3 SERPINB5 MAPK8 FOS SELE HRK ACHE CSRP2 NOS2 H2AFY JDP2 ATF2 HBG2 MAPK3 JUNB JUND BIOCARTA_AKAPCENTROSOME_PATHWAY%MSIGDB_C2%BIOCARTA_AKAPCENTROSOME_PATHWAY BIOCARTA_AKAPCENTROSOME_PATHWAY PCNT RHOA MAP2 CDK1 PRKCE PPP2CA PKN1 PRKAR2B PRKAG1 PRKACG PRKAR2A PPP1CA NUP85 AKAP9 PRKACB PID_NFAT_3PATHWAY%MSIGDB_C2%PID_NFAT_3PATHWAY PID_NFAT_3PATHWAY RCAN1 YWHAB FKBP8 YWHAQ BAX YWHAG BCL2 YWHAH YWHAZ BCL2L1 PRKCE EP300 RAN CASP3 MAP3K8 CSNK1A1 PRKACA MAP3K1 FKBP1A MAPK9 PIM1 BAD CSNK2A1 MAPK14 CAMK4 PPP3R1 SFN NR4A1 NUP214 NFATC3 CREBBP KPNA2 PRKCG PRKCH GSK3B PRKCQ AKAP5 CHP1 PRKCB NFATC2 PRKCA RCAN2 NFATC1 CABIN1 PPP3CA MAPK8 PPP3CB PRKCD MEF2D PRKCZ XPO1 YWHAE KPNB1 MAPK3 BIOCARTA_ACH_PATHWAY%MSIGDB_C2%BIOCARTA_ACH_PATHWAY BIOCARTA_ACH_PATHWAY BAD PTK2B CHRNB1 PIK3CA MUSK CHRNG RAPSN YWHAH SRC FASLG PTK2 PIK3R1 FOXO3 TERT PIK3CG AKT1 ST_JNK_MAPK_PATHWAY%MSIGDB_C2%ST_JNK_MAPK_PATHWAY ST_JNK_MAPK_PATHWAY MAP3K3 DUSP8 TRAF6 PAPPA MAP3K12 DLD NR2C2 MAP3K4 IL1R1 MAP2K7 GAB1 MAP3K10 MAP2K4 MAP3K13 MAP3K1 MAPK7 MAPK8 MYEF2 MAPK9 MAP3K11 TAB2 TAB1 MAPK10 TP53 MAP2K5 SHC1 CDC42 MAP3K2 ATF2 GCK JUN GADD45A NFATC3 AKT1 DUSP4 MAP3K9 MAP3K7 MAP3K5 DUSP10 PID_NOTCH_PATHWAY%MSIGDB_C2%PID_NOTCH_PATHWAY PID_NOTCH_PATHWAY CDKN1A YY1 DLK1 DNER EP300 NOTCH2 NOTCH3 MYCBP NOTCH4 DLL3 DLL4 JAG2 CNTN6 MIB1 IL4 NEURL1 LNX1 CNTN1 GATA3 ITCH MARK2 SSPO JAG1 HDAC1 RBBP8 NCOR2 CCND1 CTBP1 DTX1 DNM1 DLL1 MFAP5 MFAP2 PTCRA CBL ENO1 SKP2 NOTCH1 FBXW7 NCOR1 ADAM10 RAB11A FURIN ADAM12 PSENEN CUL1 MAML2 SKP1 KDM1A NUMB PSEN1 MAML1 MYC APH1A RBPJ NCSTN APH1B EPS15 SPEN PID_BMP_PATHWAY%MSIGDB_C2%PID_BMP_PATHWAY PID_BMP_PATHWAY CER1 ZFYVE16 BMPR2 PPP1R15A GREM1 XIAP SMAD1 NOG SMAD6 SMAD5 BMPR1A BMP7 FST BMP6 SKI GSK3B SMAD4 SMURF2 BMP4 SMURF1 PPP1CA SMAD7 BMP2 BAMBI TAB2 TAB1 SOSTDC1 AHSG HFE2 RGMB CHRD RGMA BMPR1B SMAD9 MAPK1 NUP214 CTDSPL PPM1A CHRDL1 MAP3K7 CTDSP1 CTDSP2 PID_CD8_TCR_DOWNSTREAM_PATHWAY%MSIGDB_C2%PID_CD8_TCR_DOWNSTREAM_PATHWAY PID_CD8_TCR_DOWNSTREAM_PATHWAY TNF IL2 IL2RA HRAS IL2RB BRAF PRKCE IFNA14 IFNA16 IFNA17 HLA-A CD8A B2M MAPK9 IFNA10 CD3G CD3E CD3D EOMES NRAS PPP3R1 CD247 MAPK1 TNFRSF4 TNFRSF18 JUN IFNA21 NFATC3 PRF1 FOSL1 KRAS PTPN7 IFNAR2 IFNAR1 ELK1 EGR4 FASLG IFNG MAP2K2 PRKCQ RAF1 TNFRSF9 PRKCB NFATC2 PRKCA NFATC1 PPP3CA MAPK8 PPP3CB FOS GZMB STAT4 IFNA5 IFNA4 CD8B IFNA7 IFNA6 IFNA1 IL2RG IFNA2 MAP2K1 MAPK3 EGR1 JUNB IFNA8 BIOCARTA_EXTRINSIC_PATHWAY%MSIGDB_C2%BIOCARTA_EXTRINSIC_PATHWAY BIOCARTA_EXTRINSIC_PATHWAY F7 PROC F2 F2R PROS1 F10 SERPINC1 F3 F5 FGB FGA FGG TFPI PID_PTP1B_PATHWAY%MSIGDB_C2%PID_PTP1B_PATHWAY PID_PTP1B_PATHWAY RHOA LAT PIK3CA LCK GRB2 EGF CSF1R JAK2 ITGA2B CAPN1 LEP STAT3 FCGR2A INSR CSN2 SRC ITGB3 PDGFB IRS1 CAV1 BLK YBX1 PDGFRB LYN NOX4 FYN SOCS3 CRK YES1 FGR SPRY2 HCK INS STAT5A STAT5B LEPR TYK2 BCAR1 SHC1 PIK3R1 CDH2 TRPV6 EGFR PTPN1 DOK1 FER CSF1 PRL AKT1 CSK TXN PRLR BIOCARTA_STEM_PATHWAY%MSIGDB_C2%BIOCARTA_STEM_PATHWAY BIOCARTA_STEM_PATHWAY CD8A IL6 IL5 IL2 IL7 IL9 CD4 IL11 CXCL8 CSF3 CSF2 CSF1 EPO IL4 IL3 PID_NFAT_TFPATHWAY%MSIGDB_C2%PID_NFAT_TFPATHWAY PID_NFAT_TFPATHWAY TNF DGKA SLC3A2 PTPRK IL2 IKZF1 GBP3 EGR2 RNF128 EGR4 IL2RA CD40LG FASLG IFNG MAF EGR3 CASP3 CDK4 PRKCQ PTGS2 IL4 BATF3 NFATC2 IL3 CTLA4 NFATC1 PPARG GATA3 ITCH FOS IL5 CREM TLE4 POU2F1 CXCL8 CBLB TBX21 PTPN1 CSF2 JUN E2F1 NFATC3 EGR1 JUNB FOSL1 IRF4 FOXP3 PID_TCPTP_PATHWAY%MSIGDB_C2%PID_TCPTP_PATHWAY PID_TCPTP_PATHWAY STAT1 VEGFA RAB4A LMAN1 EIF2AK2 STAT6 PIK3CA GRB2 EGF SOS1 INS STAT5A STAT5B CSF1R PIAS1 PTPN2 ITGB1 GAB1 PIK3CD PIK3R3 PIK3R2 PIK3CB HGF KDR STAT3 MET INSR SRC ATR SHC1 PDGFB PIK3R1 EGFR PTPN1 ITGA1 CSF1 KPNB1 CREBBP JAK3 JAK1 PDGFRB KPNA2 EIF2A BIOCARTA_BLYMPHOCYTE_PATHWAY%MSIGDB_C2%BIOCARTA_BLYMPHOCYTE_PATHWAY BIOCARTA_BLYMPHOCYTE_PATHWAY PTPRC CD40 ITGB2 CD80 HLA-DRA HLA-DRB1 CR2 FCGR2B ITGAL ICAM1 CR1 BIOCARTA_MAL_PATHWAY%MSIGDB_C2%BIOCARTA_MAL_PATHWAY BIOCARTA_MAL_PATHWAY MAPK8 LIMK1 RHOA SRF ROCK1 HNF1A HRAS MAP2K2 MAL MAPK1 CDC42 DIAPH1 RAF1 MAP2K1 RAC1 MAP4K2 MAPK3 MAP3K1 ACTA1 BIOCARTA_IL22BP_PATHWAY%MSIGDB_C2%BIOCARTA_IL22BP_PATHWAY BIOCARTA_IL22BP_PATHWAY STAT1 SOCS3 STAT3 STAT6 STAT4 STAT2 TYK2 IL22 IL10RA STAT5A STAT5B IL22RA2 JAK2 IL22RA1 JAK3 JAK1 BIOCARTA_LYM_PATHWAY%MSIGDB_C2%BIOCARTA_LYM_PATHWAY BIOCARTA_LYM_PATHWAY PECAM1 ITGB2 CXCL8 CD34 VCAM1 ITGB1 ITGAL ICAM1 IL1A SELL ITGA4 PID_EPO_PATHWAY%MSIGDB_C2%PID_EPO_PATHWAY PID_EPO_PATHWAY PTPN11 BTK RAPGEF1 STAT1 SOCS3 NFKB1 INPP5D CRKL HRAS BCL2 PLCG1 GRB2 SOS1 STAT5A STAT5B BCL2L1 TRPC6 JAK2 CBL SH2B3 EPOR TEC GAB1 MAPK8 SHC1 MAPK14 PIK3R1 IRS2 PTPN6 RAP1A EPO PLCG2 LYN VAV2 NABA_CORE_MATRISOME%MSIGDB_C2%NABA_CORE_MATRISOME NABA_CORE_MATRISOME RSPO1 CTHRC1 COL16A1 COL13A1 IGFBP4 IGFBP3 COL14A1 COL11A1 COL12A1 BGN COL11A2 COL19A1 COL10A1 COL28A1 COL26A1 COL27A1 COL24A1 COL25A1 COL22A1 COL23A1 COL2A1 COL5A1 COL5A3 COL7A1 COL5A2 COL9A1 COL20A1 COL8A2 COL21A1 COL8A1 COL9A3 COL9A2 VCAN SPP1 SLIT2 VIT SPON2 SPON1 SPARC DMP1 GLDN TSKU HMCN2 EYS VWA5B2 VWA5B1 FNDC7 FNDC8 CRISPLD1 FNDC1 CRISPLD2 ANOS1 SPARCL1 MXRA5 DDX26B OTOG CILP BSPH1 SRPX ECM1 ECM2 TINAGL1 ELN RSPO2 RSPO3 TINAG RSPO4 SBSPON VWA5A VWA9 CDCP2 NOV PXDN MATN1 VWA1 VWA2 CRELD1 MFGE8 CRELD2 GAS6 MATN4 MATN3 MATN2 VWA7 RELN TNXB VWCE EGFLAM SRPX2 BGLAP ABI3BP CILP2 VWA3A VWA3B DSPP SMOC2 LRG1 SMOC1 COMP EFEMP2 EFEMP1 BMPER DMBT1 IBSP TNN TNR SVEP1 TECTA TECTB POSTN IGFBP5 ADIPOQ IGFBP2 PCOLCE VWDE IGFALS EMID1 FBLN7 FBN2 FBN3 LTBP4 DPT FBLN1 COL17A1 LTBP2 AEBP1 DCN LTBP3 FBLN2 LTBP1 FBLN5 VTN IGFBP7 IGFBP6 AMELX AMELY AMBN CRIM1 PXDNL OTOL1 IGSF10 TGFBI FBN1 SNED1 TNFAIP6 WISP3 CYR61 WISP1 WISP2 EMILIN3 EMILIN2 EMILIN1 OIT3 EDIL3 FGB FGA VWF FGG MEPE ELSPBP1 MMRN1 MMRN2 ZP1 ZP3 ZP2 ZP4 PCOLCE2 SSPO FGL1 FGL2 NDNF THBS2 COCH POMZP3 THBS4 THSD4 THBS3 IGFBPL1 SLIT1 SLIT3 COL18A1 ZPLD1 LAMA5 LGI1 COL15A1 LGI4 LAMA2 LGI3 LAMC3 LGI2 LAMA1 TSPEAR LAMA4 NELL2 LAMA3 MFAP5 PAPLN MFAP4 NTN4 NELL1 NTN5 FRAS1 LAMC2 MFAP1 LAMC1 MFAP3 NID1 MGP NID2 MFAP2 NTN1 KCP NTN3 HMCN1 NTNG1 NTNG2 LAMB3 LAMB2 LAMB4 LAMB1 NPNT HSPG2 USH2A COLQ COL4A2 COL4A1 COL4A4 COL6A2 COL6A1 COL4A3 COL4A6 COL6A3 COL4A5 COL6A6 COL6A5 AGRN IGFBP1 CTGF COL1A1 OPTC OGN OMD PRG2 PRG4 TNC PRG3 CHAD SPOCK2 THBS1 SPOCK3 SPOCK1 BCAN EPYC FMOD PODNL1 COL3A1 KERA COL1A2 IMPG1 IMPG2 FN1 ASPN CHADL ESM1 PODN HAPLN3 HAPLN4 HAPLN1 HAPLN2 SRGN PRELP ACAN NCAN LUM NYX BIOCARTA_SHH_PATHWAY%MSIGDB_C2%BIOCARTA_SHH_PATHWAY BIOCARTA_SHH_PATHWAY GLI2 SMO SHH PTCH1 GSK3B PRKAR1B PRKAR2B GLI1 DYRK1A GLI3 PRKAR1A DYRK1B PRKACG PRKAR2A SUFU PRKACB PID_P53_REGULATION_PATHWAY%MSIGDB_C2%PID_P53_REGULATION_PATHWAY PID_P53_REGULATION_PATHWAY DAXX RFWD2 CCNG1 CHEK1 PPP2R4 YY1 TRIM28 PPP2CA EP300 CSNK1A1 CSNK1D PRMT5 CSE1L CSNK1E CCNA2 KAT2B MAPK9 CSNK1G3 USP7 TP53 CSNK1G2 CSNK1G1 ATR RPL11 MAPK14 HUWE1 CREBBP CDKN2A CDK2 MDM2 ATM ABL1 HIPK2 GSK3B KAT5 SKP2 RPL5 DYRK2 SETD8 MAPK8 SETD7 UBE2D1 TP53AIP1 RASSF1 PPP1R13L PIN1 KAT8 RPL23 PRKCD FBXO11 CHEK2 PPM1D SMYD2 E4F1 TTC5 MDM4 RCHY1 NEDD8 AKT1 BIOCARTA_INSULIN_PATHWAY%MSIGDB_C2%BIOCARTA_INSULIN_PATHWAY BIOCARTA_INSULIN_PATHWAY PTPN11 MAPK8 FOS PIK3CA SRF ELK1 HRAS INSR CSNK2A1 GRB2 SOS1 SLC2A4 INS SHC1 PIK3R1 IRS1 JUN PIK3CG RAF1 MAP2K1 RASA1 MAPK3 PID_FAS_PATHWAY%MSIGDB_C2%PID_FAS_PATHWAY PID_FAS_PATHWAY BTK PDPK1 MAPK11 PIK3CA FAS FASLG RFC1 CASP8 CASP10 CASP3 FADD RIPK1 IKBKG MAP2K6 CFLAR MAP2K7 EZR PIK3CD MAP3K1 BIRC2 PIK3R3 CHUK BIRC3 PIK3R2 PIK3CB MAPK8 MAPK9 MAPK10 CLTC SYK SRC MAPK14 PIK3R1 IKBKB FAIM2 SMPD1 BID AKT1 BIOCARTA_EIF_PATHWAY%MSIGDB_C2%BIOCARTA_EIF_PATHWAY BIOCARTA_EIF_PATHWAY EIF4A1 EIF4G1 EIF1AX EIF2S2 EIF2S1 EIF3A EIF1 EIF5 EIF2S3 EIF4A2 EIF4G3 EIF4G2 EIF4E EEF2K EEF2 EIF6 ST_IL_13_PATHWAY%MSIGDB_C2%ST_IL_13_PATHWAY ST_IL_13_PATHWAY JAK2 IL13 IL13RA2 IL13RA1 IL4R TYK2 JAK1 PID_BCR_5PATHWAY%MSIGDB_C2%PID_BCR_5PATHWAY PID_BCR_5PATHWAY PDPK1 SH3BP5 NFKB1 CD72 IBTK PIK3AP1 PIK3CA HRAS GRB2 SOS1 IKBKG MAP4K1 MAP3K1 CHUK NFKBIB CD22 CSNK2A1 SYK MAPK14 IKBKB NFKBIA PTPRC CAMK2G MAPK1 DAPP1 JUN LYN VAV2 BTK CD79B CD79A INPP5D ELK1 TRAF6 BCL10 MALT1 PTEN ETS1 RAF1 NFATC1 PPP3CA MAPK8 PPP3CB PPP3CC FOS POU2F2 BCL2A1 CARD11 SHC1 PIK3R1 PAG1 RELA DOK1 CD19 PTPN6 BLNK AKT1 PLCG2 RAC1 MAP2K1 CSK FCGR2B RASA1 MAPK3 MAP3K7 PID_ER_NONGENOMIC_PATHWAY%MSIGDB_C2%PID_ER_NONGENOMIC_PATHWAY PID_ER_NONGENOMIC_PATHWAY GNB1 RHOA MSN MAPK11 PIK3CA HRAS STRN IGF1R GRB2 SOS1 ROCK2 NOS3 PELP1 PLCB3 PLCB1 PLCB2 GNAZ IGF1 GNAL GNAI3 GNAI1 GNAI2 GNA14 MMP2 GNA13 GNA15 GNA11 GNG2 GNAO1 GNAQ BCAR1 MMP9 SRC SHC1 PIK3R1 ESR2 HBEGF NRAS AKT1 ESR1 KRAS SA_REG_CASCADE_OF_CYCLIN_EXPR%MSIGDB_C2%SA_REG_CASCADE_OF_CYCLIN_EXPR SA_REG_CASCADE_OF_CYCLIN_EXPR CDKN2A CCNE2 CCNE1 PRB1 CDKN1B CCNA1 CDK2 E2F2 E2F4 CDK4 CCND1 E2F1 CCNA2 BIOCARTA_INTRINSIC_PATHWAY%MSIGDB_C2%BIOCARTA_INTRINSIC_PATHWAY BIOCARTA_INTRINSIC_PATHWAY F9 PROC F11 F2 F8 KLKB1 F2R KNG1 COL4A2 SERPING1 COL4A1 COL4A4 COL4A3 PROS1 COL4A6 F10 COL4A5 SERPINC1 F5 FGB FGA F12 FGG PID_INTEGRIN5_PATHWAY%MSIGDB_C2%PID_INTEGRIN5_PATHWAY PID_INTEGRIN5_PATHWAY PLAUR TGFBR1 VTN SDC1 VCAM1 FN1 ITGA4 ITGB8 PLAU MADCAM1 ITGB7 FBN1 ITGB6 CYR61 ITGAV EDIL3 ITGB5 BIOCARTA_TID_PATHWAY%MSIGDB_C2%BIOCARTA_TID_PATHWAY BIOCARTA_TID_PATHWAY TNF TNFRSF1A NFKB1 RB1 TP53 IFNGR1 IFNGR2 IFNG IKBKB NFKBIA USH1C WT1 DNAJA3 JAK2 LIN7A RELA TAX1BP3 HSPA1A TNFRSF1B BIOCARTA_CELL2CELL_PATHWAY%MSIGDB_C2%BIOCARTA_CELL2CELL_PATHWAY BIOCARTA_CELL2CELL_PATHWAY CTNNB1 ACTN1 PXN BCAR1 SRC PTK2 PECAM1 VCL CTNNA3 ACTN3 CTNNA2 ACTN2 CTNNA1 CSK SIG_CHEMOTAXIS%MSIGDB_C2%SIG_CHEMOTAXIS SIG_CHEMOTAXIS ITPR3 PAK3 BTK PIK3CA PAK4 PPP1R13B ROCK2 PTEN INPPL1 CFL2 PIK3CG PAK2 PIK3CD PAK7 PAK6 PIK3R5 ACTR3 LIMK1 ACTR2 SAG ROCK1 MYLK WASL ANGPTL2 MYLK2 GDI1 RACGAP1 GDI2 PIK3R1 PAK1 RPS4X RHO PITX2 CDC42 WASF1 ARHGAP4 AKT2 AKT1 AKT3 ITPR1 ARHGAP1 PDK1 ARHGEF11 ITPR2 CFL1 PID_S1P_S1P1_PATHWAY%MSIGDB_C2%PID_S1P_S1P1_PATHWAY PID_S1P_S1P1_PATHWAY VEGFA RHOA GNAO1 KDR PLCG1 ITGB3 PDGFB S1PR1 ABCC1 SPHK1 MAPK1 PLCB2 GNAZ PTGS2 GNAI3 ITGAV RAC1 GNAI1 MAPK3 PDGFRB GNAI2 BIOCARTA_SKP2E2F_PATHWAY%MSIGDB_C2%BIOCARTA_SKP2E2F_PATHWAY BIOCARTA_SKP2E2F_PATHWAY TFDP1 CUL1 RB1 CCNE1 SKP1 CCNA1 CDC34 CDK2 E2F1 SKP2 BIOCARTA_BCR_PATHWAY%MSIGDB_C2%BIOCARTA_BCR_PATHWAY BIOCARTA_BCR_PATHWAY BTK CD79B CD79A ELK1 HRAS PLCG1 GRB2 SOS1 RAF1 PRKCB NFATC2 MAP3K1 PRKCA NFATC1 PPP3CA MAPK8 PPP3CB PPP3CC FOS NFATC4 CALM3 CALM1 CALM2 SYK SHC1 MAPK14 JUN BLNK NFATC3 RAC1 MAP2K1 MAPK3 VAV1 LYN PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY%MSIGDB_C2%PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY MEF2C DDIT3 MAPKAPK2 MAPKAPK5 MAPK11 HBP1 RAB5A MAPKAPK3 ATF1 PLA2G4A PTGS2 RPS6KA5 PPARGC1A ELK4 CREB1 SLC9A1 KRT8 USF1 KRT19 ATF6 RPS6KA4 TP53 CSNK2A1 CSNK2A2 GDI1 MAPK14 CSNK2B CEBPB NOS2 ATF2 MITF EIF4E JUN HSPB1 EIF4EBP1 ESR1 MKNK1 MEF2A BIOCARTA_AGR_PATHWAY%MSIGDB_C2%BIOCARTA_AGR_PATHWAY BIOCARTA_AGR_PATHWAY PAK3 MUSK SP1 PAK4 RAPSN GIT2 ITGB1 DVL1 CHRNA1 PAK2 PAK7 PAK6 MAPK8 DMD UTRN CHRM1 NRG1 PXN NRG2 SRC PTK2 PAK1 EGFR NRG3 ITGA1 MAPK1 CDC42 LAMA2 DAG1 JUN CTTN LAMA4 RAC1 LAMA3 MAPK3 ACTA1 BIOCARTA_LAIR_PATHWAY%MSIGDB_C2%BIOCARTA_LAIR_PATHWAY BIOCARTA_LAIR_PATHWAY TNF IL6 C3 VCAM1 SELPLG ITGAL ICAM1 C6 C5 C7 ITGA4 IL1A KNG1 ITGB2 CXCL8 ITGB1 SELP PID_RET_PATHWAY%MSIGDB_C2%PID_RET_PATHWAY PID_RET_PATHWAY PTPN11 RHOA CRK FRS2 PIK3CA HRAS GRB2 SOS1 GAB1 CREB1 PRKACA PRKCA GRB10 RET MAPK8 GFRA1 GDNF GRB7 PXN BCAR1 PDLIM7 DOK4 DOK5 SRC PTK2 DOK6 SHC1 PIK3R1 IRS1 MAPK1 IRS2 DOK1 RAP1A JUN NCK1 RAC1 MAPK3 RASA1 SA_FAS_SIGNALING%MSIGDB_C2%SA_FAS_SIGNALING SA_FAS_SIGNALING PDE6D ENDOU CASP8 CASP3 FAS CFLAR BCL2 FASLG CFL1 BIOCARTA_GPCR_PATHWAY%MSIGDB_C2%BIOCARTA_GPCR_PATHWAY BIOCARTA_GPCR_PATHWAY GNGT1 GNB1 ELK1 HRAS PLCG1 ADCY1 RAF1 PRKCB GNAI1 NFATC2 CREB1 PRKCA NFATC1 PPP3CA PPP3CB PPP3CC FOS NFATC4 CALM3 CALM1 GNAQ CALM2 PRKAR1B RPS6KA3 PRKAR2B JUN NFATC3 PRKAR1A PRKACG MAP2K1 PRKAR2A MAPK3 GNAS PRKACB PID_INTEGRIN_A4B1_PATHWAY%MSIGDB_C2%PID_INTEGRIN_A4B1_PATHWAY PID_INTEGRIN_A4B1_PATHWAY TLN1 MYH2 CRK ADAM28 ARF6 GIT1 YWHAZ PTPRA ITGB1 DOCK1 PRKACA THBS1 MDK PTK2B VCAM1 CD81 PXN FN1 BCAR1 THBS2 SRC PTK2 ITGA4 SPP1 IGSF8 AMICA1 PRKAR1B ABI1 PRKAR1A RAC1 CD14 PRKACB JAM2 BIOCARTA_CHEMICAL_PATHWAY%MSIGDB_C2%BIOCARTA_CHEMICAL_PATHWAY BIOCARTA_CHEMICAL_PATHWAY STAT1 TLN1 BAD CYCS BAX PXN TP53 BCL2 ATM EIF2S1 PTK2 CASP7 BCL2L1 CASP9 CASP6 CASP3 APAF1 BID PARP1 AKT1 PRKCB PRKCA WNT_SIGNALING%MSIGDB_C2%WNT_SIGNALING WNT_SIGNALING AXIN1 WNT1 FGF4 WNT2 APC PPP2R1A WNT3 WNT4 CCND3 WNT3A PPP2CA EP300 CSNK1A1 WISP1 FBXW11 CSNK1D WNT9A LRP6 FZD1 FZD2 B2M FZD5 FZD4 CTNNB1 DKK1 FZD6 TLE2 KREMEN1 FZD8 CTNNBIP1 CSNK1G1 CSNK2A1 AES GAPDH TCF7 WIF1 GSK3A WNT2B PITX2 CCND1 JUN BCL9 DIXDC1 CTBP1 ACTB LEF1 FRAT1 SOX17 BTRC FBXW4 WNT8A TLE1 FSHB FOSL1 CCND2 RPL13A FBXW2 PYGO1 SFRP4 RHOU SFRP1 HPRT1 CXXC4 CTBP2 NKD1 PORCN FZD3 FOXN1 FRZB WNT16 SENP2 WNT10A GSK3B NLK DVL1 DVL2 WNT11 WNT7B DAAM1 WNT7A SLC9A3R1 T WNT5B TCF7L1 WNT5A FZD7 LRP5 MYC WNT6 BIOCARTA_SPPA_PATHWAY%MSIGDB_C2%BIOCARTA_SPPA_PATHWAY BIOCARTA_SPPA_PATHWAY GNGT1 F2RL3 GNB1 HRAS F2 SYK SRC PTK2 F2R ITGA1 PLA2G4A MAPK1 PTGS1 TBXAS1 PLCB1 RAF1 ITGB1 MAP2K1 PRKCB GNAI1 MAPK3 PRKCA BIOCARTA_SRCRPTP_PATHWAY%MSIGDB_C2%BIOCARTA_SRCRPTP_PATHWAY BIOCARTA_SRCRPTP_PATHWAY CCNB1 CDC25C CDC25B CDK1 PRKCB CSK GRB2 CDC25A SRC PRKCA PTPRA PID_HIF2PATHWAY%MSIGDB_C2%PID_HIF2PATHWAY PID_HIF2PATHWAY VEGFA ELK1 SP1 SERPINE1 TWIST1 CITED2 EP300 EGLN1 SLC2A1 EGLN3 ETS1 EGLN2 EPAS1 SIRT1 SLC11A2 POU5F1 ADORA2A APEX1 EIF3E EFNA1 FXN ARNT MMP14 FLT1 KDR ABCG2 PGK1 EPO TCEB2 TCEB1 HIF1AN CREBBP BHLHE40 VHL PID_EPHRINB_REV_PATHWAY%MSIGDB_C2%PID_EPHRINB_REV_PATHWAY PID_EPHRINB_REV_PATHWAY PTPN13 FYN YES1 TIAM1 FGR PIK3CA HCK LCK ITGA2B NCK2 MAP2K4 FGB CXCR4 FGA FGG MAPK8 RGS3 SRC ITGB3 EFNB2 PIK3R1 EFNB1 EPHB2 EPHB1 EPHB4 DNM1 RAC1 BLK MAP3K7 LYN PID_CD40_PATHWAY%MSIGDB_C2%PID_CD40_PATHWAY PID_CD40_PATHWAY TRAF1 NFKB1 MAPK11 TRAF6 CD40LG STAT5A BCL2L1 TNFAIP3 IL4 MAP2K4 MAP3K1 BIRC2 BIRC3 MAPK8 TRAF2 CD40 MAPK9 MAP3K14 C4BPA MAPK10 FCAMR TDP2 TRAF3 MAPK14 NFKBIA CBLB RELA MYC JUN AKT1 JAK3 PID_MTOR_4PATHWAY%MSIGDB_C2%PID_MTOR_4PATHWAY PID_MTOR_4PATHWAY YWHAB PDPK1 RHOA MTOR PML YWHAQ RPS6KB1 HRAS YWHAG YWHAH BRAF YY1 YWHAZ EIF4B FBXW11 PPARGC1A EIF4A1 TSC2 CCNE1 DDIT4 PXN SSPO IKBKB NRAS IRS1 MAPK1 SFN EIF4E EEF2K KRAS CLIP1 CDK2 PLD1 PLD2 MAP2K2 TSC1 SREBF1 RAF1 PRKCA CYCS RPS6KA1 MAPKAP1 PRR5 MLST8 RB1CC1 RICTOR ATG13 RRAGA RPTOR RRAGC DEPTOR RRAGB RRAGD ULK2 AKT1S1 ULK1 BNIP3 RRN3 YWHAE POLDIP3 RHEB PDCD4 AKT1 EIF4EBP1 RAC1 MAP2K1 MAPK3 SGK1 EEF2 BIOCARTA_PPARA_PATHWAY%MSIGDB_C2%BIOCARTA_PPARA_PATHWAY BIOCARTA_PPARA_PATHWAY TNF NR0B2 RXRA RB1 PIK3CA ME1 APOA1 CD36 APOA2 ACOX1 CPT1B EHHADH HSD17B4 LPL MRPL11 DUT NR2F1 EP300 FABP1 FAT1 HSPA1A PIK3CG PPARGC1A PPARA NFKBIA MAPK1 NR1H3 NCOR2 JUN PDGFA CREBBP SP1 INS STAT5A STAT5B CITED2 NRIP1 PTGS2 PRKCB DUSP1 PRKCA NCOA1 MED1 NCOR1 SRA1 PIK3R1 RELA NOS2 MYC PRKAR1B PRKAR2B PRKAR1A PRKACG PRKAR2A MAPK3 HSP90AA1 PRKACB PID_P73PATHWAY%MSIGDB_C2%PID_P73PATHWAY PID_P73PATHWAY PML RB1 CDKN1A BRCA2 CHEK1 BAX SERPINE1 YAP1 FAS NEDD4L EP300 WT1 GATA1 CASP2 JAG2 SIRT1 TP63 CCNA2 PEA15 RNF43 S100A2 ITCH AEN UBE4B NDUFS2 CCNE2 HAGH PFDN5 FBXO45 GRAMD4 HSF1 CLCA2 BUB3 DCP1B BCL2L11 MAPK14 CCNB1 SFN GNB2L1 PLK3 IL4R BIN1 RAD51 CDK6 TP53I3 MAPK11 SP1 TUBA1A CDK2 MDM2 CDK1 TP73 BBC3 IL1RAP ABL1 KAT5 SERPINA1 TP53AIP1 FLOT2 PLK1 PIN1 FASN AFP ADA RCHY1 BUB1 FOXO3 RELA NTRK1 PPAP2A MYC BAK1 HEY2 WWOX GDF15 JAK1 DEDD PRKACB PID_WNT_CANONICAL_PATHWAY%MSIGDB_C2%PID_WNT_CANONICAL_PATHWAY PID_WNT_CANONICAL_PATHWAY FZD5 AXIN1 PPP2R5A NKD2 APC CTNNB1 CSNK1G1 WNT3A GSK3A GSK3B RANBP3 KLHL12 PI4K2A DVL1 DVL2 CAV1 DVL3 LRP6 CUL3 PIP5K1B PID_KIT_PATHWAY%MSIGDB_C2%PID_KIT_PATHWAY PID_KIT_PATHWAY PTPN11 PDPK1 STAT1 RPS6KB1 PIK3CA HRAS BCL2 GRB2 KIT SOS1 JAK2 EPOR MAP4K1 GAB1 GRB10 BAD STAT3 CREBBP PTPRO PIK3C2B SPRED2 LYN SPRED1 STAP1 SH2B2 KITLG SOCS1 MATK CRKL SNAI2 PTEN STAT5A MAP2K2 CBL GSK3B SH2B3 TEC RAF1 MAPK8 GRAP2 SHC1 PIK3R1 FOXO3 DOK1 MITF FER PTPN6 EPO AKT1 MAP2K1 VAV1 MAPK3 PID_ERBB1_INTERNALIZATION_PATHWAY%MSIGDB_C2%PID_ERBB1_INTERNALIZATION_PATHWAY PID_ERBB1_INTERNALIZATION_PATHWAY ARHGEF7 SPRY2 UBE2D2 PIK3CA ZFYVE28 UBE2D3 CHMP3 HRAS STAMBP GRB2 EGF SOS1 RAB5A CBL RAF1 PIK3CD PIK3R3 PIK3R2 PIK3CB UBE2D1 USP8 ITSN1 SRC PTK2 SHC1 SH3KBP1 PIK3R1 EGFR NRAS CBLB SH3GL2 HGS TSG101 CDC42 EPN1 AMPH DNM1 LRIG1 EPS15 SYNJ1 KRAS BIOCARTA_ERK5_PATHWAY%MSIGDB_C2%BIOCARTA_ERK5_PATHWAY BIOCARTA_ERK5_PATHWAY MEF2C PIK3CA MEF2D HRAS RPS6KA1 GRB2 PLCG1 SHC1 PIK3R1 NTRK1 MAPK1 PIK3CG MEF2BNB-MEF2B AKT1 CREB1 MAPK3 MAPK7 MEF2A PID_FGF_PATHWAY%MSIGDB_C2%PID_FGF_PATHWAY PID_FGF_PATHWAY FGF1 PTPN11 PDPK1 PLAUR STAT1 FGF4 PIK3CA FGF23 FGF8 FGF9 PAK4 CAMK2A GRB2 SOS1 PLAU FGF17 GAB1 HGF SSH1 FGF19 FGF18 CTNND1 SRC MAPK1 JUN CDH1 SPRY2 FRS2 SDC2 PLCG1 KLB STAT5B IL17RD NCAM1 FGFR4 FGFR3 FGFR2 CBL BGLAP FGF2 FGF6 FOS PTK2B MET RPS6KA1 MMP9 SHC1 PIK3R1 CDH2 FGFR1 SPP1 RUNX2 CTTN AKT1 MAPK3 BIOCARTA_DEATH_PATHWAY%MSIGDB_C2%BIOCARTA_DEATH_PATHWAY BIOCARTA_DEATH_PATHWAY TNFRSF10A NFKB1 BCL2 XIAP CASP7 CASP9 CASP6 CASP8 CASP10 TRADD CASP3 TNFSF12 FADD RIPK1 APAF1 DFFB DFFA CFLAR TNFRSF25 SPTAN1 GAS2 BIRC2 CHUK BIRC3 LMNA TRAF2 MAP3K14 CYCS NFKBIA TNFSF10 RELA BID TNFRSF10B PID_MYC_REPRESS_PATHWAY%MSIGDB_C2%PID_MYC_REPRESS_PATHWAY PID_MYC_REPRESS_PATHWAY ITGB4 DDIT3 CDKN1A CDKN1B ERBB2 BRCA1 PPP2R4 BCL2 EP300 HDAC3 SMAD2 SMAD4 IRF8 SMAD3 CFLAR CREB1 RBL1 TSC2 DKK1 S100A7 CEBPA HDAC1 LGALS1 NDRG1 SPI1 CCND1 GADD45A PDGFRB ITGA6 SFRP1 SP1 DNTT MAX ITGB1 GFI1 CLU ZBTB17 FTH1 HMGCS2 SLC11A1 DNMT3A TMEFF2 CSDE1 TMEM126A ALDH9A1 CCL5 WNT5A NDRG2 ZFP36L1 COL1A2 GTF2H2 SFXN3 TJP2 MXD4 FOXO3 CEBPD TBP MYC ID2 NFYA NFYB NFYC CDKN2B BIOCARTA_CELLCYCLE_PATHWAY%MSIGDB_C2%BIOCARTA_CELLCYCLE_PATHWAY BIOCARTA_CELLCYCLE_PATHWAY CDKN2A CDK6 CDKN2D RBL1 TFDP1 RB1 CCNE1 CDKN1A CDKN1B CCNA1 CDK2 CDK1 CCND3 CCNB1 CDK7 CCNH CDK4 CCND1 E2F1 CDC25A CDKN2C CCND2 CDKN2B BIOCARTA_CBL_PATHWAY%MSIGDB_C2%BIOCARTA_CBL_PATHWAY BIOCARTA_CBL_PATHWAY PDGFRA MET GRB2 EGF SRC CSF1R SH3KBP1 EGFR CBL PRKCB SH3GLB1 SH3GLB2 PRKCA BIOCARTA_NTHI_PATHWAY%MSIGDB_C2%BIOCARTA_NTHI_PATHWAY BIOCARTA_NTHI_PATHWAY TNF NFKB1 MAP3K14 TGFBR1 TGFBR2 MAPK11 TLR2 MAPK14 IKBKB NFKBIA EP300 CXCL8 RELA SMAD4 SMAD3 NR3C1 MAP2K6 MAP2K3 CREBBP IL1B DUSP1 MAP3K7 MYD88 CHUK PID_INTEGRIN1_PATHWAY%MSIGDB_C2%PID_INTEGRIN1_PATHWAY PID_INTEGRIN1_PATHWAY PLAUR VTN TGFBI PLAU FBN1 FGB FGA FGG COL11A1 COL11A2 CD81 THBS2 ITGA4 ITGA3 COL2A1 COL5A1 ITGA2 ITGA1 COL7A1 COL5A2 COL18A1 IGSF8 LAMA5 LAMA2 ITGA8 LAMA1 ITGAV LAMA4 LAMA3 ITGA7 CD14 ITGA6 LAMC2 LAMC1 VEGFA NID1 ITGA9 LAMB3 LAMB2 CSPG4 COL1A1 LAMB1 NPNT ITGA10 ITGA11 COL4A1 COL4A4 COL6A2 COL6A1 COL4A3 COL4A6 COL6A3 ITGB1 COL4A5 TNC THBS1 TGM2 MDK COL3A1 VCAM1 COL1A2 FN1 ITGA5 SPP1 F13A1 JAM2 BIOCARTA_GATA3_PATHWAY%MSIGDB_C2%BIOCARTA_GATA3_PATHWAY BIOCARTA_GATA3_PATHWAY GATA3 IL5 MAPK14 MAF IL13 PRKAR1B PRKAR2B MAP2K3 IL4 PRKAR1A PRKACG NFATC2 PRKAR2A JUNB NFATC1 PRKACB BIOCARTA_RAS_PATHWAY%MSIGDB_C2%BIOCARTA_RAS_PATHWAY BIOCARTA_RAS_PATHWAY NFKB1 RHOA BAD PIK3CA RALA ELK1 HRAS PLD1 RALGDS BCL2L1 PIK3R1 CASP9 RELA CDC42 RALBP1 PIK3CG RAF1 AKT1 MAP2K1 RAC1 MAPK3 FOXO4 CHUK BIOCARTA_IGF1_PATHWAY%MSIGDB_C2%BIOCARTA_IGF1_PATHWAY BIOCARTA_IGF1_PATHWAY PTPN11 MAPK8 FOS PIK3CA SRF ELK1 HRAS CSNK2A1 IGF1R GRB2 SOS1 SHC1 PIK3R1 IRS1 JUN PIK3CG RAF1 IGF1 MAP2K1 RASA1 MAPK3 ST_PAC1_RECEPTOR_PATHWAY%MSIGDB_C2%ST_PAC1_RECEPTOR_PATHWAY ST_PAC1_RECEPTOR_PATHWAY ASAH1 GAST GNAQ DAG1 CAMP ITPKB ITPKA BIOCARTA_PYK2_PATHWAY%MSIGDB_C2%BIOCARTA_PYK2_PATHWAY BIOCARTA_PYK2_PATHWAY CRKL HRAS PLCG1 GRB2 SOS1 MAP2K2 RAF1 MAP2K3 MAP2K4 PRKCB MAP3K1 PRKCA MAPK8 PTK2B CALM3 CALM1 GNAQ CALM2 BCAR1 SRC SHC1 MAPK14 PAK1 MAPK1 JUN RAC1 MAP2K1 MAPK3 PID_AR_PATHWAY%MSIGDB_C2%PID_AR_PATHWAY PID_AR_PATHWAY HIP1 TGFB1I1 ZMIZ1 APPL1 NCOA6 NCOA4 LATS2 CARM1 MAK ZNF318 SNURF XRCC6 UBE3A BRCA1 KDM3A XRCC5 TMF1 PATZ1 CCND3 HNRNPA1 PIAS3 SVIL KDM4C PA2G4 CMTM2 CASP8 PIAS4 PIAS1 PELP1 TMPRSS2 KLK3 KLK2 CTNNB1 CDK11B UBA3 FKBP4 CCND1 RPS6KA3 UBE2I TCF4 CTDSP1 CTDSP2 CDKN2A CDK6 SRF PAWR NRIP1 NCOA2 MED1 FHL2 PRKDC PTK2B NKX3-1 AR GSN KDM1A PRDX1 TGIF1 AKT1 RANBP9 VAV3 BIOCARTA_AT1R_PATHWAY%MSIGDB_C2%BIOCARTA_AT1R_PATHWAY BIOCARTA_AT1R_PATHWAY MEF2C ELK1 HRAS GRB2 SOS1 MAP2K2 RAF1 MAP2K4 PRKCB MAP3K1 PRKCA MAPK8 PTK2B CALM3 AGT CALM1 GNAQ CALM2 MEF2D SRC PTK2 SHC1 PAK1 EGFR MAPK1 ATF2 JUN MEF2BNB-MEF2B RAC1 MAP2K1 MAPK3 AGTR1 MEF2A BIOCARTA_CCR5_PATHWAY%MSIGDB_C2%BIOCARTA_CCR5_PATHWAY BIOCARTA_CCR5_PATHWAY MAPK8 FOS PTK2B CALM3 CALM1 GNAQ CALM2 PLCG1 CCR5 CCL4 MAPK14 CXCL12 CCL2 JUN PRKCB CXCR4 PRKCA BIOCARTA_EPONFKB_PATHWAY%MSIGDB_C2%BIOCARTA_EPONFKB_PATHWAY BIOCARTA_EPONFKB_PATHWAY NFKBIA ARNT JAK2 NFKB1 RELA CDKN1A EPOR EPO GRIN1 SOD2 HIF1A HALLMARK_PI3K_AKT_MTOR_SIGNALING%MSIGDB_C2%HALLMARK_PI3K_AKT_MTOR_SIGNALING HALLMARK_PI3K_AKT_MTOR_SIGNALING ATF1 UBE2D3 SLA RPS6KA3 FGF6 TBK1 PPP2R1B ARHGDIA RPS6KA1 CFL1 AKT1 PITX2 MAP3K7 AP2M1 PDK1 MAP2K3 PRKCB TSC2 TIAM1 DDIT3 CSNK2B TRIB3 PFN1 RAF1 SQSTM1 MAPKAP1 PIK3R3 ITPR2 DAPP1 ACACA HSP90B1 PRKAR2A THEM4 SFN RIPK1 PLCG1 FGF22 MAP2K6 SMAD2 FGF17 IL4 ARPC3 CDK4 CDK2 CDK1 UBE2N PIN1 GRB2 CALR MYD88 NFKBIB GSK3B ARF1 CDKN1A CDKN1B YWHAB CAB39L CLTC PTEN PRKAG1 SLC2A1 FASLG ECSIT RPTOR GNGT1 RAC1 HRAS NCK1 ACTR3 VAV3 ACTR2 PLA2G12A DUSP3 TRAF2 IRAK4 NGF TNFRSF1A LCK AKT1S1 PLCB1 RALB PRKAA2 CAB39 CXCR4 ADCY2 NOD1 IL2RG EGFR MAPK9 GNA14 MAPK8 MKNK1 ADRBK1 MKNK2 E2F1 MAPK1 EIF4E PAK4 STAT2 PTPN11 PPP1CA MAPK10 PIKFYVE RIT1 CAMK4 HALLMARK_MYOGENESIS%MSIGDB_C2%HALLMARK_MYOGENESIS HALLMARK_MYOGENESIS GABARAPL2 MEF2C ACTN3 ACTN2 ACSL1 DAPK2 IFRD1 MYL4 MYL7 ADCY9 PPP1R3C BIN1 MYL1 MYL2 MYL3 CFD FLII SYNGR2 STC2 APOD WWTR1 DTNA GADD45B DMPK IGF1 OCEL1 MYLPF COL1A1 SMTN SLC6A8 PKIA FXYD1 HRC SSPN RYR1 MYOM1 ACHE MYL6B PYGM MYOM2 CSRP3 ANKRD2 CD36 SPTAN1 MYOG TEAD4 MYBPC3 TNNC1 SPHK1 GAA TNNC2 PGAM2 SIRT2 MRAS TNNT1 TNNT2 TNNT3 PICK1 MAPRE3 KIFC3 CRYAB HBEGF TAGLN CTF1 CHRNG DMD CKB MEF2D SH3BGR SPDEF NQO1 SVIL GSN CKM AGL MYBPH SORBS1 SORBS3 FABP3 COL3A1 FKBP1B TCAP AGRN CRAT COX6A2 FGF2 CLU SLN PPFIA4 KCNH1 KCNH2 CHRNB1 TPM3 TPM2 FST IGFBP3 COL4A2 ADAM12 APLNR PVALB CHRNA1 NOTCH1 AK1 PSEN2 AEBP1 FOXO4 COX7A1 CACNA1H CNN3 LARGE BAG1 IGFBP7 MYH11 PRNP FDPS TGFB1 CAV3 GNAO1 REEP1 BHLHE40 MYF6 PLXNB2 ITGB1 ITGB5 ITGB4 SCHIP1 HSPB8 FHL1 HSPB2 ATP2A1 LDB3 LSP1 IQCJ-SCHIP1 SGCD SGCA MB BDKRB2 SPEG NOS1 SGCG PTGIS ATP6AP1 GPX3 NAV2 ACTA1 MYH1 MYH2 PTP4A3 MYH3 COL6A2 CASQ2 MYH8 ITGA7 COL6A3 CDH13 MYH9 CASQ1 MYH4 MYH7 CAMK2B HDAC5 COL15A1 LAMA2 CKMT2 ABLIM1 EFS ERBB3 TNNI1 TNNI2 NCAM1 CACNG1 PDLIM7 SH2B1 PDE4DIP TPD52L1 SOD3 MAPK12 ACTC1 DES MYO1C KLF5 PC ST5 SCD LPIN1 PFKM TSC2 CDKN1A RIT1 EIF4A2 RB1 APP VIPR1 SPARC ENO3 MYLK GJA5 AKT2 MYOZ1 EPHB3 MEF2A HALLMARK_PROTEIN_SECRETION%MSIGDB_C2%HALLMARK_PROTEIN_SECRETION HALLMARK_PROTEIN_SECRETION ICA1 CLTA MAPK1 RAB22A GOLGA4 SCRN1 AP1G1 LAMP2 TMED2 KIF1B ARFIP1 AP3S1 ATP7A DNM1L SH3GL2 CTSC RAB2A TPD52 DST STX7 COG2 ADAM10 OCRL AP3B1 SCAMP1 ARFGAP3 SCAMP3 DOPEY1 TOM1L1 VAMP7 RER1 TMX1 ZW10 ERGIC3 VAMP4 SSPN SEC22B VAMP3 ATP6V1B1 RPS6KA3 NAPA COPB2 STX12 CD63 TMED10 TSG101 SGMS1 STX16 COPB1 VPS4B AP2M1 GOSR2 USO1 ATP1A1 CLCN3 NAPG CLN5 LMAN1 SNX2 TSPAN8 AP2S1 ATP6V1H YKT6 SEC31A ABCA1 ARFGEF1 ARFGEF2 MON2 CAV2 BNIP3 GBF1 M6PR AP2B1 STAM IGF2R ARCN1 SOD1 GALC KRT18 RAB14 GNAS YIPF6 ANP32E PPT1 RAB9A VPS45 SEC24D GLA RAB5A PAM ARF1 COPE BET1 CLTC EGFR SNAP23 HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION%MSIGDB_C2%HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION GADD45B COL1A1 SLC6A8 OXTR SERPINE2 WIPF1 SERPINE1 COL12A1 ENO2 GJA1 TAGLN LGALS1 ANPEP DPYSL3 PRSS2 P3H1 DKK1 SFRP4 SFRP1 COL8A2 MYL9 MXRA5 PFN2 SDC4 THY1 SERPINH1 JUN MAGEE1 COL3A1 CADM1 GADD45A FUCA1 FN1 FZD8 COL1A2 FGF2 ID2 CALU SDC1 SNAI2 FERMT2 ECM1 ECM2 ELN TPM2 AREG GLIPR1 IGFBP3 TIMP3 COL4A2 QSOX1 ADAM12 TIMP1 TNFRSF12A IL15 BGN EMP3 RHOB MMP14 GAS1 CD44 MATN3 MATN2 LRRC15 FOXC2 COL11A1 CAPG FSTL1 FSTL3 NT5E TGFB1 ABI3BP GPC1 SPP1 FLNA CD59 MSX1 CAP2 ITGB1 IL32 ITGB5 VEGFC VEGFA FAP FAS FMOD CRLF1 COL16A1 TNC PLOD3 PLOD2 SGCD PLOD1 SAT1 PVR LOXL1 LOXL2 CTGF SGCG CDH6 COMP RGS4 EFEMP2 CDH2 BASP1 TGM2 PDGFRB POSTN TPM4 COL6A2 IGFBP4 WNT5A TPM1 IGFBP2 COL6A3 APLP1 PCOLCE GEM LOX COL4A1 PPIB SCG2 NOTCH2 FBN2 LAMA2 COPA NNMT NTM HTRA1 TNFRSF11B FBLN1 NID2 FBLN2 FBLN5 CALD1 VCAM1 BDNF TFPI2 INHBA IL6 DAB2 BMP1 CXCL12 COL5A1 COL5A3 COL5A2 TGFBI FBN1 CXCL6 CXCL8 MCM7 ITGB3 TNFAIP3 CXCL1 LAMC2 LAMC1 CYR61 SGCB PMEPA1 ITGAV EDIL3 COLGALT1 MMP1 ITGA2 MMP2 MMP3 PLAUR GPX7 DCN TGFBR3 GREM1 ACTA2 VCAN CDH11 ITGA5 LRP1 PCOLCE2 LAMA1 LAMA3 THBS2 THBS1 PTHLH SPOCK1 SLIT3 SLIT2 MEST PDLIM4 CTHRC1 PRRX1 LUM MFAP5 COL7A1 MGP PMP22 PTX3 VIM SNTB1 DST SPARC MYLK HALLMARK_MYC_TARGETS_V1%MSIGDB_C2%HALLMARK_MYC_TARGETS_V1 HALLMARK_MYC_TARGETS_V1 EEF1B2 FBL RUVBL2 TXNL4A KPNA2 EIF1AX IFRD1 RPS5 RPS6 UBE2E1 ILF2 TUFM SRSF2 SNRPG NHP2 SRSF3 ERH SRSF7 PPIA SNRPA KPNB1 PSMD14 GLO1 CUL1 PHB G3BP1 ORC2 PGK1 CYC1 NOP16 CBX3 GOT2 EIF2S2 EIF2S1 GNB2L1 LSM2 LSM7 COPS5 UBA2 IARS EIF4G2 YWHAE SLC25A3 HSP90AB1 YWHAQ MRPL9 ACP1 RFC4 NCBP1 VBP1 NCBP2 H2AFZ CAD CTPS1 RAD23B CCNA2 TFDP1 MCM4 SNRPA1 ETF1 MCM5 MCM6 MCM2 PRPS2 HDAC2 SRSF1 DDX21 U2AF1 SRM PPM1G HSPD1 CDC45 TRA2B POLD2 FAM120A EIF4H SNRPB2 BUB3 HNRNPA1 NOP56 HNRNPA3 RRM1 DUT SSB CNBP NAP1L1 DEK HSPE1 TOMM70A IMPDH2 EIF3J POLE3 SSBP1 ABCE1 EIF3D RAN EIF3B MCM7 CDK4 CDK2 EIF4E AP3S1 EIF4A1 RPL34 HNRNPU HNRNPR EPRS PWP1 PHB2 RPL6 UBE2L3 RRP9 PSMD8 CDC20 PSMD7 SNRPD2 TRIM28 SNRPD1 MYC PSMD3 PSMD1 SNRPD3 RPS10 DDX18 SMARCC1 STARD7 RPL22 MRPS18B KARS CLNS1A VDAC3 VDAC1 HPRT1 SET CSTF2 NOLC1 GSPT1 PRDX3 LDHA PRDX4 PCBP1 XRCC6 PA2G4 MRPL23 SRPK1 AIMP2 HNRNPD RNPS1 HNRNPC RPLP0 SYNCRIP XPO1 C1QBP DHX15 CCT3 CCT2 PABPC4 GNL3 NME1 PSMA6 PSMA4 PSMA1 PSMA2 TCP1 CANX PABPC1 SF3B3 PCNA ODC1 TYMS COX5A PSMA7 EXOSC7 PSMB2 PSMB3 USP1 RPS3 RPL14 RPS2 RPL18 CCT7 CCT5 CCT4 RANBP1 SF3A1 NPM1 PTGES3 RSL1D1 PSMC6 XPOT PSMC4 APEX1 HNRNPA2B1 SERBP1 NDUFAB1 PRPF31 HDGF TARDBP MAD2L1 HDDC2 HALLMARK_ESTROGEN_RESPONSE_EARLY%MSIGDB_C2%HALLMARK_ESTROGEN_RESPONSE_EARLY HALLMARK_ESTROGEN_RESPONSE_EARLY ADCY9 STC2 GJA1 SVIL AREG CD44 BAG1 REEP1 BHLHE40 HSPB8 NAV2 TGM2 IGFBP4 ABLIM1 TPD52L1 CXCL12 ABAT NADSYN1 AQP3 TSKU RAPGEFL1 FAM134B SOX3 RPS6KA2 MYB KRT8 KCNK15 PDZK1 OVOL2 SULT2B1 AR CLDN7 NBL1 PTGES TIAM1 SLC22A5 PEX11A ENDOD1 SEC14L2 UGCG SYNGR1 INPP5F SLC19A2 FDFT1 XBP1 EGR3 BCL11B TIPARP SIAH2 ABCA3 SFN GREB1 MED13L FASN UNC119 RET LAD1 CLIC3 PRSS23 FAM102A ANXA9 RRP12 JAK2 ELOVL5 ELOVL2 ITPK1 MYOF GFRA1 FOS GAB2 CBFA2T3 RHOD IL17RB NCOR2 SLC7A5 TUBB2B MED24 MPPED2 RARA SLC2A1 TFF3 TFF1 MAPT FOXC1 TMPRSS3 ADCY1 TMEM164 PAPSS2 SLC7A2 AKAP1 OLFML3 FLNB MICB CA12 FARP1 SLC16A1 KRT13 SNX24 DHRS2 KLK10 DHRS3 KRT19 MYBBP1A DLC1 KRT15 TJP3 FRK SCARB1 FCMR WWC1 HR CELSR1 CELSR2 IGF1R DEPTOR CCND1 TBC1D30 SLC39A6 SYBU MREG CISH NPY1R KAZN OLFM1 PLA2G16 RAB31 SCNN1A PPIF PGR IL6ST FKBP4 SLC27A2 FKBP5 SLC26A2 ARL3 ABHD2 SLC1A1 RHOBTB3 ISG20L2 SLC1A4 RASGRP1 SLC9A3R1 CALCR PODXL ALDH3B1 PMAIP1 TFAP2C SLC37A1 OPN3 WFS1 INHBB BCL2 DHCR7 KCNK5 B4GALT1 NXT1 MAST4 FHL2 AFF1 MYC WISP2 CALB2 CYP26B1 MYBL1 MSMB KLF10 TGIF2 DYNLT3 ELF1 ELF3 ESRP2 BLVRB CANT1 SLC24A3 SEMA3B ASB13 ADD3 TOB1 THSD4 MUC1 PDLIM3 P2RY2 NRIP1 LRIG1 RBBP8 SH3BP5 FAM63A HES1 KRT18 KDM4B ZNF185 TPBG AMFR KLF4 TTC39A MLPH SYT12 CHPT1 RAB17 GLA HALLMARK_CHOLESTEROL_HOMEOSTASIS%MSIGDB_C2%HALLMARK_CHOLESTEROL_HOMEOSTASIS HALLMARK_CHOLESTEROL_HOMEOSTASIS ERRFI1 GLDC TMEM97 ANTXR2 CXCL16 ACTG1 TM7SF2 FADS2 LGALS3 NSDHL ALCAM PDK3 FBXO6 GUSB STARD4 PCYT2 HMGCS1 ANXA13 ECH1 ANXA5 GPX8 AVPR1A LSS SREBF2 PLSCR1 ETHE1 PPARG ALDOC MVD ATF5 ATF3 IDI1 DHCR7 MVK ACSS2 FAM129A LPL HMGCR HSD17B7 ACAT2 GNAI1 ADH4 ATXN2 EBP NFIL3 CBS PMVK TP53INP1 TRIB3 SC5D SCD MAL2 STX5 LDLR S100A11 SEMA3B FDFT1 ABCA2 GSTM2 JAG1 CHKA CYP51A1 PNRC1 SQLE FABP5 CD9 FASN CTNNB1 CPEB2 LGMN PLAUR CLU TNFRSF12A FDPS HALLMARK_KRAS_SIGNALING_UP%MSIGDB_C2%HALLMARK_KRAS_SIGNALING_UP HALLMARK_KRAS_SIGNALING_UP APOD TNNT2 HBEGF FUCA1 ID2 IGFBP3 SPP1 INHBA TNFAIP3 ITGA2 PLAUR PRRX1 SPON1 ADAMDEC1 IKZF1 ADGRA2 FBXO4 C3AR1 SOX9 EPHB2 SCN1B CMKLR1 ST6GAL1 ATG10 EREG BTC RBP4 SLPI MALL SPARCL1 TRIB1 TRIB2 CFB ZNF277 TPH1 ABCB1 GYPC CFH HSD11B1 ANKH TSPAN7 EPB41L3 MAP7 PLEK2 KCNN4 TSPAN1 RABGAP1L ACE JUP LIF IGF2 CIDEA AMMECR1 PPBP GNG11 NR0B2 SNAP91 GADD45G ITGBL1 CCSER2 STRN AVL9 PIGR NRP1 PTPRR MTMR10 CROT CTSS AKAP12 CD37 MAP4K1 FCER1G MMD ARG1 VWA5A EMP1 PDCD1LG2 MMP10 DUSP6 WDR33 LAT2 ANO1 MMP11 GPRC5B IL1B TLR8 ANGPTL4 SDCCAG8 ENG SATB1 PTGS2 HOXD11 RELN GPNMB CAB39L CBR4 MPZL2 IL33 MAP3K1 CCL20 IL10RA TMEM176B GABRA3 TMEM176A LAPTM5 NR1H4 WNT7A G0S2 PSMB8 DCBLD2 TMEM158 CFHR2 F2RL1 ADGRL4 PLVAP NGF CSF2 F13A1 PLAT PRDM1 ETS1 ERO1L CCND2 CXCR4 FGF9 KIF5C PLAU GUCY1A3 IL2RG ANXA10 CLEC4A ADAM17 PCP4 MYCN SCG5 ADAM8 SCG3 HIST1H2BB TOR1AIP2 LY96 CSF2RA PCSK1N BTBD3 EVI5 CBX8 SLMO2 GFPT2 CXCL10 YRDC BMP2 MAFB DNMBP CPE IL7R SNAP25 FLT4 ITGB2 TMEM100 RBM4 CA2 PRKG2 CDADC1 PEG3 ETV1 TRAF1 BPGM TNFRSF1B MMP9 ETV4 ETV5 PTBP2 ALDH1A3 ZNF639 ALDH1A2 HKDC1 PECAM1 IRF8 LCP1 DOCK2 BIRC3 PPP1R15A RGS16 USP12 USH1C GLRX RETN CBL TFPI HDAC9 IL1RL2 PTCD2 GALNT3 NAP1L2 NIN TSPAN13 SPRY2 SEMA3B KLF4 AKT2 HALLMARK_NOTCH_SIGNALING%MSIGDB_C2%HALLMARK_NOTCH_SIGNALING HALLMARK_NOTCH_SIGNALING WNT2 SKP1 CCND1 PSENEN FZD1 TCF7L2 FZD5 FBXW11 FZD7 PRKCA HES1 SAP30 RBX1 HEYL KAT2A PPARD CUL1 WNT5A NOTCH2 NOTCH1 PSEN2 NOTCH3 MAML2 DTX1 ARRB1 DTX2 DTX4 DLL1 APH1A LFNG JAG1 ST3GAL6 HALLMARK_UV_RESPONSE_DN%MSIGDB_C2%HALLMARK_UV_RESPONSE_DN HALLMARK_UV_RESPONSE_DN ERBB2 SPOP HAS2 FYN APBB2 PDLIM5 MGMT ATP2B4 ATP2B1 CDC42BPA MAPK14 PEX14 ACVR2A TJP1 FAM179B NFIB AGGF1 ADGRL2 COL1A1 SERPINE1 NRP1 PIK3R3 GJA1 COL3A1 COL1A2 CDKN1B SNAI2 PTEN COL11A1 DLC1 BHLHE40 CAP2 SCHIP1 IGF1R ICA1 IQCJ-SCHIP1 PRKCA RGS4 PDGFRB NOTCH2 PPARG IRS1 PRDM2 NR3C1 EFEMP1 ZMIZ1 AKT3 FBLN5 CDON FHL2 PIAS3 MYC IGFBP5 BDNF SFMBT1 PRKCE MAGI2 DYRK1A DAB2 RUNX1 TFPI INPP4B SCN8A MAP1B AMPH COL5A2 MT1E ATP5S PTGFR LDLR YTHDC1 INSIG1 SDC2 ITGB3 LPAR1 ADD3 CACNA1A KALRN LTBP1 LAMC1 ATXN1 CYR61 GRK5 PRKAR2B MAP2K5 SMAD3 FZD2 RBPMS CAV1 NEK7 NR1D2 SYNJ2 NFKB1 SMAD7 DLG1 TGFBR3 ID1 CDK13 BMPR1A PHF3 CITED2 CELF2 PIK3CD PTPN21 PTPRM VLDLR RND3 SYNE1 NIPBL DBP SIPA1L1 SLC22A18 ABCC1 WDR37 ANXA2 MIOS DUSP1 ANXA4 BCKDHB ATRX PMP22 F3 TGFBR2 VAV2 ATRN ARHGEF9 PLCB4 DDAH1 PAPD7 MMP16 ADORA2B PPAP2B KCNMA1 KIT RASA2 MET MGLL GCNT1 MRPS31 SRI ATP2C1 SLC7A1 SCAF8 MTA1 RXRA HALLMARK_SPERMATOGENESIS%MSIGDB_C2%HALLMARK_SPERMATOGENESIS HALLMARK_SPERMATOGENESIS MAP7 ACE RFC4 SNAP91 PRKAR2A CDK1 CLPB SCG5 CHRM4 GFI1 SCG3 PEBP1 ACRBP CCT6B CLGN TEKT2 PCSK1N NEK2 PAPOLB IL13RA2 TCP11 AGFG1 NOS1 CAMK4 TLE4 TKTL1 PRM2 CSNK2A2 TALDO1 ZPBP PIAS2 ADAM2 ADCYAP1 ZC2HC1C THEG IFT88 MTNR1A GAPDHS HOXB1 TSSK2 STAM2 CFTR DPEP3 DDX4 HSPA4L ALOX15 ACTL7B SPATA6 GMCL1 NCAPH ART3 OAZ3 PGS1 LDHC CCNB2 NPHP1 PGK2 IP6K1 ZC3H14 RPL39L GSTM3 PDHA2 ODF1 BRAF HSPA2 MLLT10 GPR182 RAD17 PSMG1 NF2 LPIN1 CNIH2 VDAC3 EZH2 CRISP2 SYCP1 MAST2 HIST1H1T YBX2 IDE SLC2A5 PHF7 PCSK4 COIL SHE GRM8 GSG1 TOPBP1 NEFH HBZ PACRG NPY5R PARP2 DCC STRBP ELOVL3 SEPT4 SIRT1 TSN MLF1 CCNA1 ARL4A DBF4 MEP1B DMC1 ACRV1 KIF2C DDX25 TTK TULP2 CST8 AKAP4 AURKA TUBA3C ZNRF4 PHKG2 ADAD1 TNNI3 DNAJB8 BUB1 JAM3 CLVS1 IL12RB2 SLC12A2 DMRT1 HSPA1L GAD1 NAA11 HTR5A MTOR CHFR POMC TNP2 TNP1 CDKN3 HALLMARK_UV_RESPONSE_UP%MSIGDB_C2%HALLMARK_UV_RESPONSE_UP HALLMARK_UV_RESPONSE_UP SLC6A8 ABCB1 AQP3 RFC4 SQSTM1 ENO2 DDX21 RET CDK2 FOS KCNH2 POLE3 RHOB MMP14 TFRC C4BPB ICAM1 GLS CCND3 HTR7 UROD PPAT MSX1 BSG ACAA1 PRKACA JUNB STARD3 DGAT1 PRKCD TAP1 SLC6A12 HLA-F MAPK8IP2 TUBA4A CDC34 POLG2 CCNE1 PRPF3 OLFM1 TYRO3 NPTXR CNP CHRNA5 BMP2 PPIF RRAD GPX3 MAOA IL6ST SHOX2 FKBP4 RPN1 TARS SULT1A1 STIP1 CYB5R1 BCL2L11 APOM CA2 GRPEL1 IGFBP2 HMOX1 NKX2-5 RASGRP1 NPTX2 ATP6V1C1 MARK2 ATP6V1F LYN HNRNPU KLHDC3 EPHX1 ASNS RAB27A GGH NFKBIA ATF3 PTPRD NR4A1 EIF2S3 EIF5 NAT1 STK25 LHX2 DLG4 AGO2 FGF18 CYP1A1 IL6 CDKN1C BTG3 HSPA2 BTG2 FEN1 BTG1 ALAS1 ONECUT1 AMD1 AP2S1 TCHH CLTB YKT6 CTSV ARRB2 CXCL2 SPR CHKA CASP3 HYAL2 H2AFX SIGMAR1 PDLIM3 TACR3 GAL COL2A1 TST MRPL23 IRF1 TMBIM6 ALDOA SLC25A4 CEBPG TGFBRAP1 PARP2 WIZ FURIN PPT1 SEPW1 CLCN2 HSPA13 RXRB NXF1 PPP1R2 DNAJB1 EPCAM CREG1 MGAT1 POLR2H BAK1 BID E2F5 CYB5B CDKN2B GCH1 PLCL1 NTRK3 CDC5L FMO1 PDAP1 CCK SOD2 DNAJA1 PSMC3 FOSB CDO1 NUPL1 GRINA HALLMARK_MYC_TARGETS_V2%MSIGDB_C2%HALLMARK_MYC_TARGETS_V2 HALLMARK_MYC_TARGETS_V2 EXOSC5 TCOF1 PES1 UTP20 SLC19A1 PLK4 PLK1 BYSL RCL1 LAS1L TMEM97 NDUFAF4 MPHOSPH10 FARSA PHB NOP16 CBX3 RRP9 MYC DDX18 MCM4 MCM5 NOLC1 SRM HSPD1 PA2G4 AIMP2 CDK4 RRP12 NOP56 GNL3 HSPE1 PPAN RABEPK HK2 IPO4 WDR43 MAP3K6 DUSP2 PUS1 PRMT3 SORD NPM1 WDR74 IMP4 TFB2M PPRC1 MYBBP1A SUPV3L1 GRWD1 MRTO4 DCTPP1 SLC29A2 NIP7 NOP2 NOC4L TBRG4 UNG HALLMARK_REACTIVE_OXIGEN_SPECIES_PATHWAY%MSIGDB_C2%HALLMARK_REACTIVE_OXIGEN_SPECIES_PATHWAY HALLMARK_REACTIVE_OXIGEN_SPECIES_PATHWAY LSP1 GPX3 STK25 GLRX SRXN1 MPO HHEX PPP2R4 G6PD GPX4 OXSR1 GLRX2 IPCEF1 CAT NDUFS2 VIMP FTL NDUFB4 MGST1 TXN PDLIM1 PRDX2 PRDX4 SBNO2 PRDX1 MBP NQO1 HMOX2 CDKN2D SOD1 NDUFA6 EGLN2 TXNRD2 TXNRD1 GSR PRDX6 SCAF4 ATOX1 MSRA GCLC FES ERCC2 GCLM PFKP LAMTOR5 ABCC1 SOD2 PRNP JUNB HALLMARK_INFLAMMATORY_RESPONSE%MSIGDB_C2%HALLMARK_INFLAMMATORY_RESPONSE HALLMARK_INFLAMMATORY_RESPONSE NPFFR2 IFITM1 AQP9 ICAM4 SLC4A4 NAMPT TNFSF10 IL12B PROK2 ICOSLG IL15RA IL1R1 SLC11A2 EBI3 HPN FPR1 MEFV HIF1A PIK3R5 KCNMB2 CD14 SLAMF1 MSR1 TNFSF15 EIF2AK2 NMI BST2 MARCO GPR183 TNFSF9 CD40 ADM CX3CL1 GPR132 STAB1 OLR1 CCR7 FFAR2 IL10 EDN1 RIPK2 SPHK1 IFNGR2 IL18 RHOG GP1BA TACR1 OSMR TLR1 IL1A RNF144B CD48 SERPINE1 CHST2 TLR3 HBEGF TLR2 PTGER4 PTGER2 PTAFR GNAI3 KCNA3 CXCR6 SGMS2 RELA PDPN GPC3 CCL17 CD55 CCL24 GABBR1 CCL22 SLC31A2 CD70 SLC31A1 OSM AXL ABI1 CD69 SLC28A2 IL18R1 CSF3 CSF3R CSF1 CD82 AHR BEST1 IL18RAP RGS1 LAMP3 CCRL2 CLEC5A ROS1 TIMP1 IL4R APLNR CYBB IL15 IFNAR1 LY6E EMP3 CALCRL C5AR1 MMP14 SLC1A2 PSEN1 HRH1 IRAK2 NLRP3 NDP TNFRSF9 SELE PTPRE CXCL11 SELL NMUR1 ICAM1 MXD1 RTP4 CXCL9 TNFAIP6 ATP2A2 ADGRE1 PDE4B ITGB8 BDKRB1 SCARF1 PTGIR TAPBP MEP1A IRF7 LTA LCP2 NOD2 FZD5 ACVR1B GNA15 CCL7 PVR CCL5 CCL2 KCNJ2 SEMA4D PCDH7 ADRM1 OPRK1 P2RX7 KLF6 P2RX4 IL2RB VIP LYN NFKBIA INHBA IL6 BTG2 LDLR CXCL6 CXCL8 ITGB3 LPAR1 TACR3 IRF1 PLAUR NFKB1 ITGA5 GCH1 F3 ADORA2B MET SRI ATP2C1 SLC7A1 HAS2 ATP2B1 ACVR2A C3AR1 SCN1B CMKLR1 EREG LIF RAF1 IL1B CDKN1A CCL20 IL10RA SLC7A2 DCBLD2 LCK KIF1B CXCL10 IL7R RASGRP1 TNFRSF1B RGS16 MYC ABCA1 VIMP P2RY2 TPBG HALLMARK_ADIPOGENESIS%MSIGDB_C2%HALLMARK_ADIPOGENESIS HALLMARK_ADIPOGENESIS CYC1 SSPN CD36 SORBS1 GADD45A CRAT HSPB8 DGAT1 GPX3 SULT1A1 GRPEL1 ITGA7 ECH1 COL4A1 COL15A1 PPARG LPL TST ALDOA MGLL PEX14 SPARCL1 ITSN1 ARAF GHITM LIPE SCP2 MCCC1 OMD CMBL SLC5A6 POR SDPR UQCRC1 SUCLG1 PREB RETSAT MGST3 CIDEA BAZ2A ABCB8 MRPL15 ATP5O C3 MARC2 APOE RREB1 DECR1 STAT5A FZD4 RMDN3 CS UCK1 NMT1 PEMT ORM1 COX7B GBE1 ACADL AIFM1 NKIRAS1 ACADM DLAT ACADS ADIG COX8A IFNGR1 ELMOD3 ELOVL6 MRAP PLIN2 CD302 TKT ANGPTL4 DLD ECHS1 PTGER3 ATL2 UQCR11 UQCR10 TANK ADCY6 SAMM50 UCP2 MAP4K3 CDKN2C RIOK3 MDH2 VEGFB FAH DHRS7 FABP4 GPAM CCNG2 LPCAT3 ESYT1 SLC27A1 MTCH2 PHLDB1 ACAA2 COX6A1 ENPP2 PIM3 HADH PTRF PHYH APLP2 ADIPOQ ATP1B3 LIFR SDHC SDHB ACLY GPD2 SCARB1 RAB34 CMPK1 RTN3 PFKFB3 CD151 AK2 SLC1A5 ADIPOR2 BCL2L13 DHRS7B SLC19A1 UBC G3BP2 ESRRA IDH1 EPHX2 CHCHD10 COQ9 DNAJC15 COQ5 QDPR COQ3 TALDO1 BCL6 REEP5 UQCRQ PQLC3 NABP1 ACO2 REEP6 SLC25A1 RNF11 SOWAHC ETFB SQRDL GPHN CPT2 ALDH2 DBT ME1 YWHAG PGM1 HIBCH IDH3A FAM73B BCKDHA JAGN1 DHCR7 CHUK PPM1B ACOX1 NDUFS3 SLC25A10 ITIH5 AGPAT6 PPP1R15B NDUFB7 LAMA4 RETN LTC4S AGPAT3 DDT UBQLN1 STOM SNCG GPX4 DNAJB9 DRAM2 PTCD3 NDUFA5 CAT ANGPT1 ABCA1 IDH3G CYP4B1 IMMT TOB1 PFKL LEP PRDX3 PDCD4 SOD1 ARL4A MYLK NDUFAB1 HALLMARK_ANDROGEN_RESPONSE%MSIGDB_C2%HALLMARK_ANDROGEN_RESPONSE HALLMARK_ANDROGEN_RESPONSE PDLIM5 ANKH RPS6KA3 MAP7 KRT8 AKT1 AKAP12 GNAI3 SPDEF RRP12 ELOVL5 SRP19 STEAP4 CDC14B ELK4 HERC3 B2M FADS1 ACTN1 ARID5B ACSL3 SEPP1 SORD PIAS1 AZGP1 MAF KRT19 LIFR MAK CCND3 SMS STK39 GUCY1A3 KLK3 UAP1 KLK2 IQGAP2 NDRG1 MYL12A UBE2J1 TRGC1 SLC38A2 RAB4A CCND1 UBE2I HOMER2 XRCC5 TMEM50A ZBTB10 SAT1 DHCR24 ELL2 H1F0 CDK6 APPBP2 BMPR1B TNFAIP8 ADRM1 NGLY1 DBI TPD52 ADAMTS1 PGM3 NKX3-1 FKBP5 ABCC4 SLC26A2 TSC22D1 NCOA4 ABHD2 PPAP2A SGK1 HMGCS1 HPGD SRF TMPRSS2 HSD17B14 CAMKK2 PTK2B MERTK SPCS3 VAPA CENPN GPD1L ALDH1A3 IDI1 B4GALT1 ZMIZ1 HMGCR INPP4B LMAN1 DNAJB9 SCD INSIG1 PMEPA1 XRCC6 ITGAV PA2G4 GSR SEC24D PTPN21 HALLMARK_COAGULATION%MSIGDB_C2%HALLMARK_COAGULATION HALLMARK_COAGULATION ARF4 SERPINA1 WDR1 CPQ FYN PLEK APOC4-APOC2 C8B C8A DUSP14 CASP9 THBD CTSO C8G CSRP1 HNF4A CFD CTSK CTSH HMGCS2 CTSE MBL2 CTSB FGA HPN SERPINB2 ANXA1 MMP7 VWF FGG MST1 CFB APOA1 MMP8 F2 F8 F9 CFH DCT ACOX2 MMP15 RGN ANG RAPGEF3 C1QA C1S SERPINC1 TMPRSS6 OLR1 C1R USP11 PLG CRIP2 ITIH1 CPN1 P2RY1 LEFTY2 SH2B2 C3 GP1BA SIRT2 F10 F12 F11 APOC3 KLF7 RABIF APOC1 SERPINE1 MSRB2 KLKB1 F2RL2 PF4 GSN MMP10 PRSS23 DUSP6 MMP11 FN1 CLU TIMP3 TIMP1 RAC1 MMP14 PLAT PLAU MEP1A LAMP2 COMP MMP9 HTRA1 PECAM1 TFPI2 BMP1 FBN1 CTSV ITGB3 CD9 LGMN MMP1 ITGA2 MMP2 MMP3 FURIN LRP1 THBS1 GDA PROS1 PREP CAPN5 CAPN2 S100A1 ADAM9 F3 SERPING1 MASP2 ISCU CPB2 PEF1 CFI PDGFB PROZ KLK8 C2 DPP4 C9 S100A13 LTA4H A2M SPARC GNG12 GP9 TF PROC GNB2 MAFF F13B HRG HALLMARK_APOPTOSIS%MSIGDB_C2%HALLMARK_APOPTOSIS HALLMARK_APOPTOSIS ERBB2 MGMT CASP9 TNFSF10 EREG GADD45B ANXA1 CD14 F2 ANKH SPTAN1 RETSAT IL18 DDIT3 IL1A SQSTM1 ETF1 ENO2 EGR3 RELA EMP1 GSN IFNGR1 CDK2 JUN IL1B GADD45A CD69 SATB1 CLU CDKN1A CDKN1B RARA FASLG TIMP3 TIMP1 TNFRSF12A BGN PSEN2 RHOB PSEN1 CD44 PLAT CCND2 FAS TAP1 CCND1 GNA15 SAT1 H1F0 DNM1L BMP2 GPX3 LGALS3 PDGFRB BCL2L11 HMOX1 AVPR1A IFITM3 PMAIP1 PRF1 TNF FDXR IER3 BNIP3L HGF ATF3 ERBB3 F2R CDC25B FEZ1 MADD VDAC2 BIRC3 TXNIP DAP3 DIABLO BCL10 PPP3R1 BCL2L10 IL6 RHOT2 EBP BTG3 BMF BTG2 IGFBP6 MCL1 CREBBP TGFB2 GPX4 SC5D GSTM1 PTK2 ISG20 CYLD DAP BCL2L2 BCL2L1 TOP2A CASP3 HMGB2 HSPB1 PDCD4 BRCA1 CASP7 AIFM3 CASP8 CTNNB1 IGF2R CASP6 CASP4 IRF1 PEA15 SOD1 CAV1 TIMP2 NEFH CASP1 MMP2 KRT18 TSPO CASP2 CD38 GSR SMAD7 DFFA DCN PPT1 GPX1 TGFBR3 PPP2R5B DNAJC3 DPYD PLCB2 RNASEL CCNA1 GUCY2D ROCK1 SLC20A1 LEF1 NEDD9 XIAP ADD1 BID PAK1 LMNA BCAP31 GCH1 BIK IFNB1 CFLAR CD2 LUM WEE1 CTH BAX SOD2 DNAJA1 APP HALLMARK_APICAL_SURFACE%MSIGDB_C2%HALLMARK_APICAL_SURFACE HALLMARK_APICAL_SURFACE NCOA6 HSPB1 ADIPOR2 CD160 BRCA1 SHROOM2 SULF2 AIM1 RTN4RL1 CROCC MAL GHRL RHCG MDGA1 THY1 PLAUR IL2RB ADAM10 LYN CX3CL1 DCBLD2 B4GALT1 GAS1 SRPX PCSK9 GSTM3 AKAP7 LYPD3 SLC2A4 GATA3 EFNA5 PKHD1 APP SLC22A12 SCUBE1 IL2RG FLOT2 ATP6V0A4 EPHB4 TMEM8B SLC34A3 NTNG1 AFAP1L2 ATP8B1 HALLMARK_COMPLEMENT%MSIGDB_C2%HALLMARK_COMPLEMENT HALLMARK_COMPLEMENT ACTN2 PIK3R5 CD36 OLR1 PCSK9 GATA3 RHOG GP1BA SERPINE1 GNAI3 CD55 FN1 CLU COL4A2 TIMP1 MMP14 CDA PSEN1 GMFB CBLB LIPA PRSS3 HPCAL4 FDX1 LAP3 ZFPM2 KLK1 C4BPB PLA2G7 PPP4C S100A12 RCE1 APOBEC3F APOBEC3G CD59 CP EHD1 CALM3 CALM1 PHEX AKAP10 PCLO PRKCD GNGT2 CTSL IRF7 CASP10 CTSD LCP2 DUSP5 SIRT6 RBSN F5 MMP12 CCL5 F7 MMP13 ZEB1 KIF2A CD46 WAS GNAI2 LGALS3 PPP2CB STX4 GCA PRSS36 PSMB9 PDP1 CD40LG CDK5R1 C1QC MSRB1 HSPA1A CDH13 ANXA5 FCN1 DGKG PRDM4 DOCK10 LYN PIM1 PLSCR1 USP8 S100A9 DGKH NOTCH4 VCPIP1 HSPA5 BRPF3 MT3 GNB4 CPM DOCK4 ITGAM DYRK2 DOCK9 PIK3CG TFPI2 CASP5 KYNU IL6 CR2 CR1 PLA2G4A APOA4 ADRA2B PIK3CA IRF2 L3MBTL4 LTF USP14 CTSV CEBPB USP15 USP16 TNFAIP3 SRC CXCL1 CASP3 PRCP RNF4 GNG2 SPOCK2 SH2B3 ERAP2 KCNIP2 KCNIP3 LGMN IRF1 GZMA GZMB GZMK XPNPEP1 PLAUR LRP1 PREP F3 ADAM9 SERPING1 PDGFB C2 DPP4 C9 S100A13 LTA4H GP9 GNB2 MAFF SERPINA1 CPQ FYN PLEK CASP9 CTSO CSRP1 HNF4A CTSH CTSB SERPINB2 CFB MMP8 F2 F8 CFH MMP15 ANG C1QA C1S SERPINC1 TMPRSS6 C1R PLG ITIH1 C3 F10 PFN1 RABIF RAF1 APOC1 KLKB1 CTSS FCER1G DUSP6 JAK2 GRB2 LCK PLAT GPD2 SCG3 LAMP2 CTSC CA2 RASGRP1 ME1 CASP7 CASP4 TIMP2 CASP1 ATOX1 HALLMARK_DNA_REPAIR%MSIGDB_C2%HALLMARK_DNA_REPAIR HALLMARK_DNA_REPAIR ARL6IP1 USP11 MPG GTF2B RFC4 PNP CLP1 MPC2 NCBP2 LIG1 GTF2F1 BCAM BOLA2 CMPK2 SRSF6 EIF1B TP53 VPS28 CCNO POM121 CSTF3 NPR2 COX17 SUPT4H1 AK3 XPC AK6 AAAS SDCBP DGUOK ZNF707 SAC3D1 SURF1 POLR3GL ALYREF UPF3B SUPT5H SMAD5 ZWINT POLA1 POLA2 DUT AGO4 ITPA ADA ELL CETN2 SNAPC5 POLB IMPDH2 SEC61A1 ADCY6 ZNRD1 MRPL40 GUK1 SNAPC4 REV3L DGCR8 NELFB POLL TK2 NELFCD POLH NELFE AK1 RFC5 RFC3 RFC2 CDA VPS37D NME3 NME4 EDF1 VPS37B DDB2 APRT NT5C3A DDB1 RRM2B DAD1 NFX1 POLR1C POLR1D HCLS1 UMPS GTF2A2 PDE4B RALA GTF3C5 RNMT PRIM1 GMPR2 DCTN4 POLD3 NT5C POLD4 POLR2A TAF1C POLR2C POLD1 TMED2 POLR2D POLR2E TCEB3 RBX1 POLR2F POLR2G STX3 POLR2I ADRM1 POLR2J RAE1 POLR2K SF3A3 BRF2 TAF12 TAF13 PDE6G TAF10 RPA2 GTF2H1 SSRP1 GTF2H3 TARBP2 GTF2H5 POLE4 NUDT9 RAD52 NUDT21 RAD51 ERCC3 POLR3C ERCC4 ERCC1 RPA3 ERCC8 ERCC5 TAF6 TSG101 DFNA5 FEN1 GPX4 CANT1 HPRT1 ERCC2 NME1 POLR2H BCAP31 PCNA TYMS HALLMARK_TGF_BETA_SIGNALING%MSIGDB_C2%HALLMARK_TGF_BETA_SIGNALING HALLMARK_TGF_BETA_SIGNALING PPP1CA RAB31 TJP1 BMP2 WWTR1 UBE2D3 BCAR3 BMPR2 PPP1R15A ARID4B FNTA MAP3K7 CDH1 TGIF1 CDKN1C ACVR1 IFNGR2 NOG LEFTY2 KLF10 TGFBR1 RHOA PPM1A HDAC1 LTBP2 SKIL SPTBN1 SMAD1 SERPINE1 SMURF2 SMURF1 SMAD6 HIPK2 SKI FKBP1A CDK9 APC ID3 PMEPA1 TRIM33 CTNNB1 SMAD3 FURIN SMAD7 ID1 BMPR1A ENG ID2 SLC20A1 NCOR2 XIAP THBS1 TGFB1 JUNB HALLMARK_ANGIOGENESIS%MSIGDB_C2%HALLMARK_ANGIOGENESIS HALLMARK_ANGIOGENESIS ITGAV THBD COL3A1 VCAN POSTN LRPAP1 PDGFA STC1 SERPINA5 TIMP1 VTN LUM APOH PGLYRP1 JAG2 KCNJ8 PRG2 SLCO2A1 VAV2 S100A4 LPL OLR1 TNFRSF21 FGFR1 FSTL1 CCND2 APP SPP1 COL5A2 MSX1 PTK2 CXCL6 NRP1 VEGFA JAG1 PF4 HALLMARK_PEROXISOME%MSIGDB_C2%HALLMARK_PEROXISOME HALLMARK_PEROXISOME ACSL1 PEX14 ABCB1 SCP2 RETSAT SULT2B1 CTPS1 PEX11A ELOVL5 CADM1 CNBP CRAT HRAS FADS1 FDPS DHRS3 SLC35B2 ACAA1 SLC23A2 ECI2 STS NUDT19 LONP2 MLYCD GSTK1 ACOT8 DIO1 ACSL5 UGT2B17 ACSL4 IDH1 DHCR24 CEL EPHX2 GNPAT MSH2 CRABP2 CTBP1 ABCB4 PEX11B CRABP1 CACNA1B ABCB9 SLC27A2 HSD11B2 PRDX5 RDH11 ISOC1 HAO2 FIS1 IDH2 SIAH1 ECH1 ESR2 CDK7 ALB ABCD2 ABCD3 SERPINA6 ABCD1 YWHAH ABCC8 ERCC3 ABCC5 PEX2 SLC25A17 ERCC1 SLC25A19 IDI1 PEX6 EHHADH ACOX1 ALDH1A1 PEX5 ITGB1BP1 ALDH9A1 DLG4 SEMA3C VPS4B MVP BCL10 NR1I2 HSD17B4 HSD17B11 CLN8 CLN6 SMARCC1 HMGCL TTR RXRG HSD3B7 PEX13 FABP6 SCGB1A1 CAT TOP2A IDE ATXN1 PRDX1 SOD1 SLC25A4 TSPO PABPC1 SOD2 HALLMARK_ESTROGEN_RESPONSE_LATE%MSIGDB_C2%HALLMARK_ESTROGEN_RESPONSE_LATE HALLMARK_ESTROGEN_RESPONSE_LATE TNNC1 CDH1 CKB ID2 AREG SERPINA5 CD44 LARGE BAG1 HSPB8 HOMER2 IGFBP4 SGK1 IDH2 S100A9 TPD52L1 TFPI2 BTG3 CXCL12 LTF LAMC2 FABP5 PRKAR2B GAL CD9 TST CAV1 MEST TRIM29 UNC13B METTL3 CACNA2D2 KIF20A LLGL2 SERPINA1 TSTA3 IGSF1 PLAC1 ST14 XRCC3 CDC6 ATP2B4 TH GJB3 NMU MOCS2 SNX10 IMPA2 TPSAB1 JAK1 CHST8 EMP2 HMGCS2 UGDH SLC29A1 ASCL1 PERP AGR2 GINS2 COX6C KLK11 BATF NAB2 CXCL14 ZFP36 PRLR ALDH3A2 PKP3 RNASEH2A SCUBE2 ACOX2 STIL DNAJC12 CYP4F11 RAPGEFL1 DLG5 PLXNB1 SOX3 FGFR3 RPS6KA2 ST6GALNAC2 MYB SLC2A8 MDK GPER1 PDZK1 DCXR OVOL2 LSR SULT2B1 DNAJC1 RABEP1 ASS1 NBL1 MAPK13 PTGES GALE TIAM1 SLC22A5 PTPN6 FDFT1 XBP1 EGR3 SIAH2 ABCA3 SFN RET CLIC3 PRSS23 FAM102A ANXA9 JAK2 ELOVL5 ITPK1 MYOF FOS PTGER3 IL17RB NCOR2 SLC7A5 TFF3 TFF1 MAPT FOXC1 TMPRSS3 PAPSS2 FLNB MICB CA12 FARP1 DUSP2 SLC16A1 KRT13 DHRS2 SORD KLK10 KRT19 TJP3 FRK SCARB1 PCP4 HR CELSR2 CCND1 PLK4 CISH NPY1R OLFM1 PLA2G16 RAB31 SCNN1A PPIF PGR IL6ST CPE FKBP4 SLC27A2 FKBP5 SLC26A2 ARL3 ABHD2 CA2 ETFB SLC1A4 SLC9A3R1 CALCR HSPA4L ALDH3B1 TFAP2C OPN3 WFS1 BCL2 DHCR7 KCNK5 CDC20 NXT1 AFF1 WISP2 CYP26B1 DYNLT3 BLVRB ISG20 TSPAN13 SLC24A3 HPRT1 SEMA3B ADD3 TOP2A TOB1 PDCD4 PDLIM3 NRIP1 RBBP8 TPBG AMFR KLF4 CHPT1 GLA CCNA1 HALLMARK_HEME_METABOLISM%MSIGDB_C2%HALLMARK_HEME_METABOLISM HALLMARK_HEME_METABOLISM CTNS MBOAT2 KLF3 EPOR KLF1 SLC25A38 SLC25A37 MYL4 TSPO2 ACKR1 LPIN2 TNRC6B ICAM4 SLC11A2 SLC6A8 TFRC CCND3 UROD BSG ELL2 H1F0 NCOA4 ASNS NR3C1 BTG2 PC USP15 NEK7 CTSE CTSB GYPC AQP3 MGST3 MAP2K3 BCAM C3 ENDOD1 SDCBP UCP2 RIOK3 SLC2A1 ISCA1 GDE1 SLC4A1 BACH1 NUDT4 PSMD9 CDC27 BTRC FBXO7 FBXO9 TNS1 ACSL6 GAPVD1 ANK1 RNF123 KEL DAAM1 HMBS TRIM10 OPTN SLC22A4 LAMP2 GYPA EPB42 RCL1 IGSF3 ABCB6 GYPB EPB41 GYPE DCUN1D1 SLC30A10 GATA1 SEC14L1 TSPAN5 HBQ1 CDR2 ATP6V0A1 NFE2 EIF2AK1 CA2 SLC10A3 TYR UBAC1 ALDH6A1 SLC6A9 ARL2BP BPGM RANBP10 TMCC2 HIST1H4C TMEM9B EZH1 PIGQ HBB HBD BNIP3L SLC7A11 NNT CLIC2 ERMAP HTATIP2 KAT2B TAL1 RHD TRAK2 AHSP MPP1 DMTN FAM46C CLCN3 MOCOS XPO7 PDZK1IP1 XK TCEA1 RHAG YPEL5 BLVRB ALDH1L1 NARF CAT CPOX CCDC28A RNF19A CIR1 CAST KHNYN LMO2 PRDX2 SLC30A1 MINPP1 RHCE OSBP2 SIDT2 ABCG2 FECH HBZ GMPS HTRA2 ADIPOR1 FOXO3 RAP1GAP SPTA1 MARK3 PPP2R5B FN3K UROS GCLC MARCH8 FBXO34 MARCH2 GCLM MFHAS1 SYNJ1 PQLC1 P4HA2 MKRN1 LRP10 ADD1 NFE2L1 PICALM ALAS2 FTCD ALAD HEBP1 CA1 ACP5 PGLS RBM5 ARHGEF12 GLRX5 RAD23A VEZF1 SPTB TFDP2 BMP2K TRIM58 ATG4A HAGH TOP1 KDM7A BLVRA MOSPD1 PPOX ADD2 AGPAT4 SELENBP1 MXI1 E2F2 DCAF10 DCAF11 HDGF SNCA RBM38 SMOX FOXJ2 HALLMARK_GLYCOLYSIS%MSIGDB_C2%HALLMARK_GLYCOLYSIS HALLMARK_GLYCOLYSIS PPIA STC2 PGK1 GOT2 PGAM2 CHST2 ENO2 GPC3 AGL AGRN SDC1 PPFIA4 IGFBP3 STC1 QSOX1 CD44 CACNA1H NT5E GPC1 VEGFA PLOD2 PLOD1 SAP30 KIF2A PPP2CB NSDHL PDK3 GUSB MERTK ZNF292 XYLT2 HSPA5 ENO1 HS6ST2 DPYSL4 NDST3 STMN1 GLCE ALG1 ALDH9A1 MIF PHKA2 CLDN3 CLDN9 DDIT4 RRAGD KDELR3 CLN6 RBCK1 ALDH7A1 COL5A1 PC GNE PAXIP1 SDC3 TGFBI TGFA ARPP19 CHST12 LHPP SDC2 HOMER1 PMM2 EXT1 EXT2 ARTN PYGB PYGL GYS2 GYS1 NANP RARS MIOX CHST6 ALDOA TPI1 PGAM1 AKR1A1 DEPDC1 B3GNT3 DCN CHST1 ALDOB CHST4 IDUA VCAN NOL3 CITED2 CENPA GPC4 EGLN3 MDH1 CHPF VLDLR MPI HDLBP IRS2 FAM162A SLC16A3 IL13RA1 TPST1 PKP2 DSC2 PFKFB1 GPR87 AK4 CAPN5 HMMR FUT8 NDUFV3 ANKZF1 GOT1 GFPT1 ECD SRD5A3 B3GALT6 EFNA3 P4HA1 NASP LHX9 ADORA2B GALK2 GALK1 B4GALT2 GAL3ST1 HS2ST1 MET GMPPB GMPPA PGM2 ME2 SLC37A4 CHPF2 HAX1 PKM LCT KIF20A B4GALT7 FBP2 TSTA3 B4GALT4 SLC25A13 PRPS1 RPE UGP2 BPNT1 CYB5A SLC35A3 B3GAT3 B3GAT1 SPAG4 GNPDA1 SOX9 POLR3K ANG GALE AK3 CDK1 ANGPTL4 DLD MED24 TFF3 MDH2 HK2 ERO1L CXCR4 SDHC EGFR IDH1 ABCB6 TKTL1 TALDO1 FKBP4 COG2 GAPDHS ME1 IER3 COPB2 LDHC B4GALT1 SLC25A10 GLRX G6PD ELF3 ISG20 TXN LDHA CASP6 SOD1 TPBG GCLC PAM PFKP P4HA2 BIK AURKA PGLS CTH PSMC4 MXI1 HALLMARK_FATTY_ACID_METABOLISM%MSIGDB_C2%HALLMARK_FATTY_ACID_METABOLISM HALLMARK_FATTY_ACID_METABOLISM ACSL1 HMGCS2 UGDH ALDH3A2 CD36 SUCLG1 RETSAT CIDEA H2AFZ SLC22A5 DECR1 ENO2 LGALS1 ACADL FASN ACADM ACADS ELOVL5 DLD ECHS1 CRAT MDH2 G0S2 ACAA2 HADH SDHC SMS UROD GPD2 ACAA1 ACSM3 ECI1 ECI2 AQP7 UBE2L6 IL4I1 TDO2 MLYCD ADIPOR2 NBN GLUL ACOT8 CPT1A GABARAPL1 ACSL5 SDHD ACSL4 SDHA IDH1 DHCR24 CEL ALDH3A1 GPD1 ACOT2 ERP29 PSME1 BMPR1B SUCLG2 XIST GCDH MAOA CD1D NSDHL ADH7 HSPH1 NTHL1 RDH11 RDH16 ACO2 S100A10 REEP6 HAO2 PDHA1 NCAPH2 CA2 GAPDHS GRHPR HMGCS1 HPGD VNN1 ECH1 OSTC SERINC1 ACADVL CPT2 SETD8 CYP4A22 HCCS ME1 PTPRG EPHX1 MCEE YWHAH AUH HIBCH CA4 IDH3B CA6 CBR1 IDI1 HSP90AA1 HSDL2 EHHADH ADSL ACOX1 ALDH1A1 CYP4A11 INMT HADHB ALDH9A1 MIF PPARA HSD17B7 ACAT2 FH ADH1C CYP1A1 RAP1GDS1 HSD17B4 ETFDH HSD17B11 LTC4S DLST PDHB BPHL HMGCL HSD17B10 PTS CRYZ TP53INP2 PCBD1 D2HGDH ACSS1 CPOX CBR3 IDH3G AOC3 AADAT CCDC58 GAD2 GSTZ1 LDHA FABP1 FABP2 SUCLA2 METAP1 ALDOA PRDX6 UROS MDH1 ALAD ODC1 FMO1 BCKDHB BLVRA MGLL APEX1 ENO3 HALLMARK_PANCREAS_BETA_CELLS%MSIGDB_C2%HALLMARK_PANCREAS_BETA_CELLS HALLMARK_PANCREAS_BETA_CELLS LMO2 MAFB PCSK2 PCSK1 STXBP1 SLC2A2 SRP14 FOXO1 INS NEUROD1 SCGN PAK3 NKX6-1 SEC11A NKX2-2 CHGA PKLR VDR PDX1 PAX4 PAX6 ABCC8 GCG HNF1A SYT13 ELP4 ISL1 SRP9 GCK G6PC2 SPCS1 AKT3 SST DCX SRPRB IAPP INSM1 FOXA2 NEUROG3 DPP4 HALLMARK_HEDGEHOG_SIGNALING%MSIGDB_C2%HALLMARK_HEDGEHOG_SIGNALING HALLMARK_HEDGEHOG_SIGNALING CDK6 THY1 CNTFR NRP2 RTN1 CDK5R1 LDB1 CRMP1 VLDLR NKX6-1 GLI1 ETS2 MYH9 AMOT SHH ADGRG1 OPHN1 HEY1 SCG2 DPYSL2 HEY2 SLIT1 ACHE NRCAM TLE3 TLE1 PTCH1 UNC5C L1CAM PML RASA1 NF1 PLG NRP1 VEGFA CELSR1 HALLMARK_IL2_STAT5_SIGNALING%MSIGDB_C2%HALLMARK_IL2_STAT5_SIGNALING HALLMARK_IL2_STAT5_SIGNALING TNFSF10 SYNGR2 GADD45B BMPR2 IL10 CD48 HIPK2 PTGER2 IL18R1 CSF1 AHR ECM1 IL4R RHOB PTCH1 CD44 TNFRSF21 TNFRSF9 CAPG PRNP SELL NT5E MXD1 SPP1 CCND3 BHLHE40 NDRG1 CYFIP1 RNH1 IKZF2 IKZF4 CCNE1 PDCD2L TNFSF11 WLS PRKCH IL1R2 FLT3LG TWSG1 CD79B KLF6 PENK P2RX4 ALCAM ST3GAL4 TGM2 IL2RB MAP6 SNX9 ICOS UCK2 PPAP2A CDC42SE2 CTSZ PTH1R GLIPR2 APLP1 NCS1 CTLA4 SH3BGRL2 CCR4 BATF3 PIM1 GSTO1 PLSCR1 NCOA3 IL13 RHOH FAM126B SERPINB6 CDCP1 PTRH2 TLR7 AHCY AHNAK CST7 AKAP2 PLAGL1 DCPS HUWE1 SNX14 CDKN1C CD86 RRAGD GUCY1B3 NFIL3 CD83 MYO1C N6AMT2 CD81 GPR65 RORA LCLAT1 SCN9A CAPN3 ENPP1 TNFRSF8 MAP3K8 DENND5A SLC39A8 CASP3 PHLDA1 TNFRSF4 EOMES SWAP70 ADAM19 MAPKAPK2 ITGAV GPR83 AGER SOCS2 SOCS1 POU2F1 HOPX SELP AMACR DRC1 FURIN PHTF2 SLC2A3 ITGAE SPRED2 NFKBIZ TNFRSF18 CKAP4 IRF4 IL3RA METTL20 COL6A1 ITGA6 LTB IRF6 SMPDL3A PLEC FGL2 COCH IL1RL1 LRRC8C GBP4 PRAF2 ANXA4 SPRY4 TTC39B S100A1 MYO1E SYT11 IL2RA GALM P4HA1 MAFF CDC6 BATF ABCB1 SERPINC1 RABGAP1L LIF PNP TIAM1 NRP1 XBP1 F2RL2 EMP1 IFNGR1 PLIN2 IL10RA FAH HK2 CSF2 PUS1 DHRS3 CCND2 UMPS SLC29A2 NOP2 IGF1R SLC1A5 GABARAPL1 CISH CXCL10 BMP2 GATA1 CA2 TRAF1 TNFRSF1B IFITM3 ETV4 BCL2 IRF8 ITIH5 RGS16 MYC GPX4 BCL2L1 MUC1 SHE LRIG1 IGF2R ARL4A ODC1 ENO3 HALLMARK_WNT_BETA_CATENIN_SIGNALING%MSIGDB_C2%HALLMARK_WNT_BETA_CATENIN_SIGNALING HALLMARK_WNT_BETA_CATENIN_SIGNALING FZD1 DKK1 CTNNB1 KAT2A PPARD MAML1 TCF7 HDAC11 RBPJ FZD8 NKD1 CUL1 WNT6 NCSTN LEF1 FRAT1 DVL2 NCOR2 WNT1 SKP2 WNT5B AXIN1 CSNK1E AXIN2 HDAC5 HEY1 DKK4 NUMB HEY2 NOTCH4 NOTCH1 JAG2 PSEN2 PTCH1 MYC GNAI1 CCND2 TP53 ADAM17 DLL1 JAG1 HDAC2 HALLMARK_OXIDATIVE_PHOSPHORYLATION%MSIGDB_C2%HALLMARK_OXIDATIVE_PHOSPHORYLATION HALLMARK_OXIDATIVE_PHOSPHORYLATION CYC1 GOT2 SLC25A3 TOMM70A FDX1 ACAA1 ATP6AP1 PDP1 GRPEL1 IDH2 ECH1 ATP6V1C1 ATP6V1F ALAS1 SLC25A4 MDH1 ISCU CYB5A COX6C POR UQCRC1 SUCLG1 RETSAT MGST3 MRPL15 ATP5O DECR1 CS COX17 COX7B AIFM1 ACADM DLAT SURF1 COX8A DLD ECHS1 UQCR11 UQCR10 MDH2 ACAA2 COX6A1 PHYH ISCA1 MTRR ATP5C1 PDK4 ATP6V1E1 SDHC SUPV3L1 PDHX SDHB ATP6V1G1 ATP6V0E1 AFG3L2 COX7A2L UQCRC2 ECI1 MAOB ABCB7 ATP5J ATP5I ATP5H ATP5L MRPL11 CPT1A ATP5B LDHB CYB5R3 SDHD RHOT1 SDHA IDH1 ATP5E ATP5D ACADSB POLR2F GLUD1 OGDH GPI MRPS15 MRPS11 MRPS12 MRPL34 UQCRQ COX7C MRPL35 ATP6V0B ACO2 MRPS22 HADHA PDHA1 BDH2 ATP6V0C OAT ETFB TIMM9 ALDH6A1 ATP5A1 TIMM13 ACADVL TIMM10 MRPS30 HCCS COX5B MFN2 NQO2 MTX2 LRPPRC IDH3A PHB2 TOMM22 IDH3B MTRF1 BCKDHA MPC1 NNT PMPCA ATP1B1 COX6B1 ATP5J2 NDUFS3 VDAC2 OXA1L HADHB UQCRB COX15 FH COX7A2 UQCRH NDUFB7 ACAT1 TIMM50 ETFDH RHOT2 DLST COX11 NDUFV2 PDHB NDUFV1 ATP6V1D HSD17B10 COX10 HSPA9 GPX4 CYCS ATP6V1H COX4I1 VDAC3 ETFA NDUFA5 VDAC1 ATP5G3 TCIRG1 NDUFS2 IDH3G ATP5G2 ATP5G1 IMMT OPA1 NDUFB4 TIMM17A PRDX3 UQCRFS1 LDHA NDUFC2 CASP7 NDUFC1 ATP5F1 SUCLA2 NDUFS8 NDUFS7 NDUFS6 NDUFS4 NDUFS1 NDUFA6 SLC25A5 HTRA2 SLC25A12 SLC25A11 FXN SLC25A6 NDUFB8 NDUFB6 NDUFB5 NDUFB3 NDUFB2 NDUFB1 SLC25A20 NDUFA9 TIMM8B NDUFA8 NDUFA7 NDUFA4 NDUFA2 NDUFA1 COX5A BAX NDUFAB1 HALLMARK_HYPOXIA%MSIGDB_C2%HALLMARK_HYPOXIA HALLMARK_HYPOXIA PPP1R3C STC2 DTNA PGK1 PKLR PYGM ADM GCK SRPX GAA PGAM2 SERPINE1 CHST2 ENO2 GPC3 SDC4 TES NDST2 JUN NDST1 MT2A CCRN4L WSB1 JMJD6 BCAN HOXB9 LXN NEDD4L PLAC8 PPFIA4 PRKCDBP PCK1 B4GALNT2 PPARGC1A FOSL2 SLC6A6 NCAN IGFBP3 HEXA STC1 BRS3 CSRP2 IDS EDN2 BGN AMPD3 CHST3 HAS1 GCNT2 INHA KIF5A S100A4 IGFBP1 PGF TPST2 LARGE ILVBL PKP1 TGFB3 KLHL24 EFNA1 FAM47E-STBD1 HK1 GPC1 LALBA GAPDH BHLHE40 FBP1 TMEM45A CP KDM3A PHKG1 VHL NDRG1 HS3ST1 VEGFA NAGK ACKR3 ERRFI1 PRKCA SAP30 CTGF KLF6 TGM2 PDK3 PRDX5 HMOX1 MYH9 LOX PIM1 ALDOC ZNF292 HSPA5 ENO1 ATF3 DPYSL4 NR3C1 MIF DDIT4 CDKN1C IL6 RRAGD KDELR3 NFIL3 BTG1 COL5A1 RORA MT1E SDC3 TGFBI SDC2 TNFAIP3 EXT1 PNRC1 CYR61 GYS1 ALDOA CAV1 TPI1 XPNPEP1 PLAUR DCN ALDOB SLC2A3 CITED2 GPC4 VLDLR HDLBP IRS2 FAM162A ANXA2 DUSP1 AK4 F3 ANKZF1 B3GALT6 EFNA3 PDGFB P4HA1 ADORA2B GALK1 PGM2 SLC37A4 MAFF UGP2 ZFP36 SULT2B1 PDK1 DDIT3 KLF7 TIPARP AKAP12 SIAH2 GBE1 PLIN2 ANGPTL4 RBPJ FOS CDKN1A CDKN1B MAP3K1 SLC2A1 CCNG2 HK2 CA12 PTRF ETS1 ERO1L CXCR4 EGFR SCARB1 PFKFB3 ATP7A TKTL1 GPI TPD52 SLC25A1 GAPDHS GRHPR PGM1 IER3 BNIP3L BCL2 LDHC PPP1R15A WISP2 GLRX ISG20 PFKL SLC2A5 LDHA CASP6 TPBG FOXO3 PAM PFKP P4HA2 SELENBP1 MXI1 ENO3 HALLMARK_TNFA_SIGNALING_VIA_NFKB%MSIGDB_C2%HALLMARK_TNFA_SIGNALING_VIA_NFKB HALLMARK_TNFA_SIGNALING_VIA_NFKB NAMPT IL12B ICOSLG IL15RA GADD45B GPR183 TNFSF9 OLR1 EDN1 RIPK2 SPHK1 TGIF1 IFNGR2 IL18 IL1A SERPINE1 HBEGF TLR2 PTGER4 RELA SDC4 JUN GADD45A CD69 ID2 CSF1 ETS2 FOSL2 AREG CCRL2 RHOB CD44 TNFRSF9 PTPRE CXCL11 EFNA1 ICAM1 MXD1 BHLHE40 TNFAIP6 EHD1 PDE4B JUNB VEGFA ACKR3 TAP1 TNC DUSP5 ZBTB10 SAT1 CCL5 CCL2 TNFAIP8 KLF6 TSC22D1 SGK1 GEM NFKBIA ATF3 NR4A1 INHBA KYNU IL6 BTG3 IFIT2 BTG2 NFIL3 CD83 ZC3H12A CCNL1 BTG1 IER5 IER2 IL23A NINJ1 SIK1 LDLR CXCL6 EGR1 CEBPB EGR2 PLK2 MAP3K8 CXCL2 JAG1 EIF1 DENND5A TNFAIP3 FOSL1 CXCL1 REL PHLDA1 LITAF PNRC1 IFIH1 CYR61 PANX1 DUSP4 PMEPA1 SERPINB8 TUBB2A SMAD3 FJX1 IRF1 RELB PER1 SPSB1 CLCF1 TRIP10 PLAUR CD80 NFKB1 RNF19B SLC16A6 PHLDA2 SLC2A3 FUT4 SOCS3 SNN MSC NFKB2 NR4A2 RCAN1 NR4A3 BCL3 NFKBIE IRS2 NFE2L2 TNFAIP2 CXCL3 SLC2A6 GCH1 KDM6B DDX58 BIRC2 B4GALT5 NFAT5 DUSP1 BCL2A1 CEBPD DRAM1 SOD2 DNAJB4 F3 CCL4 PTX3 FOSB LAMB3 KLF2 MARCKS TNIP1 TNIP2 KLF9 PPAP2B MAFF PLEK PDLIM5 ATP2B1 SERPINB2 TRIB1 ZFP36 LIF MAP2K3 STAT5A SQSTM1 EGR3 TIPARP IL1B FOS PTGS2 CDKN1A TANK CCL20 G0S2 F2RL1 DUSP2 CSF2 PLAU PFKFB3 CCND1 GFPT2 CXCL10 YRDC BMP2 BCL6 IL6ST IL7R TRAF1 TNF IER3 B4GALT1 BIRC3 PPP1R15A MYC KLF10 MCL1 ABCA1 HES1 KLF4 CFLAR HALLMARK_INTERFERON_ALPHA_RESPONSE%MSIGDB_C2%HALLMARK_INTERFERON_ALPHA_RESPONSE HALLMARK_INTERFERON_ALPHA_RESPONSE IFITM1 EIF2AK2 NMI BST2 C1S SAMD9L IFITM2 IFI35 TMEM140 IFI30 IFIT3 RIPK2 IFI44L NUB1 DHX58 EPSTI1 TRIM25 TRIM26 CMPK2 TRIM21 CMTR1 HERC6 RSAD2 SP110 HLA-C TRAFD1 PROCR IFI27 TRIM14 PSME2 UBA7 GMPR DDX60 HELZ2 PNPT1 IFI44 ISG15 TDRD7 PARP14 PARP12 MOV10 IL7 LPAR6 LGALS3BP OGFR ADAR OASL TRIM5 BATF2 WARS PARP9 PSMA3 CSF1 OAS1 NCOA7 CD47 IRF9 RNF31 SAMD9 LAMP3 USP18 CCRL2 SLC25A28 MVB12A GBP2 IL4R CD74 MX1 IL15 FAM46A LY6E PSMB8 B2M LAP3 CXCL11 SELL RTP4 UBE2L6 TAP1 IRF7 STAT2 CXCL10 PSME1 CNP PSMB9 IFITM3 PLSCR1 TXNIP IFIT2 ELF1 IRF2 ISG20 IFIH1 CASP8 IRF1 CASP1 GBP4 HALLMARK_UNFOLDED_PROTEIN_RESPONSE%MSIGDB_C2%HALLMARK_UNFOLDED_PROTEIN_RESPONSE HALLMARK_UNFOLDED_PROTEIN_RESPONSE NHP2 STC2 SEC11A EIF2S1 IARS SPCS1 PREB SRPRB XBP1 HSP90B1 NOP56 CALR SLC7A5 IGFBP1 ERO1L VEGFA EXOSC5 EIF4E CCL2 TARS NABP1 SLC1A4 EIF4A1 SPCS3 ASNS WFS1 HSPA5 ATF3 RRP9 GOSR2 DDIT4 KDELR3 HSPA9 DNAJB9 POP4 SEC31A CEBPB EIF4A3 IFIT1 EDC4 RPS14 NOLC1 TATDN2 KHSRP H2AFX KIF5B BANF1 CHAC1 TSPYL2 IMP3 TUBB2A SLC30A5 DDX10 PDIA6 PDIA5 ERN1 CEBPG MTHFD2 DKC1 GEMIN4 ATP6V0D1 ATF6 ATF4 DNAJC3 SHC1 BAG3 EIF4EBP1 SSR1 ZBTB17 NOP14 FUS EDEM1 EIF2AK3 LSM1 EEF2 LSM4 CNOT4 CNOT6 CNOT2 HYOU1 ALDH18A1 DCP1A EIF4G1 FKBP14 SRPR HERPUD1 CKS1B SERP1 TTC37 WIPI1 YWHAZ ARFGAP1 DCP2 SKIV2L2 EXOC2 DCTN1 NPM1 PARN CXXC1 EIF4A2 SDAD1 EXOSC4 XPOT EXOSC10 EXOSC9 EXOSC2 EXOSC1 PAIP1 NFYA NFYB YIF1A PSAT1 DNAJA4 HALLMARK_INTERFERON_GAMMA_RESPONSE%MSIGDB_C2%HALLMARK_INTERFERON_GAMMA_RESPONSE HALLMARK_INTERFERON_GAMMA_RESPONSE NAMPT TNFSF10 IL15RA FPR1 HIF1A EIF2AK2 NMI SSPN BST2 CD40 RIPK2 GBP6 HLA-B HLA-A HLA-G NUP93 IDO1 RNF213 KLRK1 ST8SIA4 SLAMF7 ST3GAL5 MT2A HLA-DQA1 GPR18 HLA-DRB1 SECTM1 CD69 IL18BP VAMP8 BANK1 PELI1 RAPGEF6 VAMP5 HLA-DMA APOL6 STAT4 METTL7B STAT1 P2RY14 STAT3 ZNFX1 SPPL2A IL4R ZBP1 IL15 IFNAR2 LY6E CD274 CSF2RB AUTS2 TOR1B MARCH1 XAF1 PML CIITA B2M EIF4E3 ITGB7 UPP1 ARID5B LATS2 LAP3 OAS2 CXCL11 OAS3 XCL1 IRF5 ICAM1 NLRC5 RTP4 SAMHD1 CXCL9 PSMB10 TNFAIP6 FCGR1A PTPN1 MX2 PDE4B LYSMD2 PTPN2 FAS TAPBP TAP1 IRF7 LCP2 CCL7 CCL5 CCL2 IL2RB PSMB9 ISOC1 PIM1 PLSCR1 NCOA3 NFKBIA VCAM1 MVP CD86 IL6 IFIT2 PLA2G4A RBCK1 BTG1 IRF2 TNFAIP3 CASP3 IFIH1 IRF1 GZMA SOCS1 SELP NFKB1 SOCS3 IRF4 TNFAIP2 GCH1 FGL2 DDX58 GBP4 SOD2 SERPING1 SRI CMKLR1 CFB CFH C1S SAMD9L C1R IFITM2 IFI35 IFI30 PNP IFIT3 IFI44L DHX58 EPSTI1 PTPN6 TRIM25 TRIM26 CMPK2 TRIM21 CMTR1 HERC6 RSAD2 SP110 TRAFD1 IFI27 TRIM14 PSME2 DDX60 RIPK1 HELZ2 PNPT1 IFI44 ISG15 TDRD7 PARP14 PARP12 IL7 JAK2 LGALS3BP OGFR ADAR OASL MYD88 BATF2 WARS PTGS2 CDKN1A PSMA3 IRF9 RNF31 USP18 IL10RA SLC25A28 CD74 MX1 PSMB8 NOD1 UBE2L6 STAT2 CXCL10 PSME1 BPGM IFITM3 IRF8 TXNIP ISG20 IFIT1 CASP7 CASP8 CASP4 CASP1 MTHFD2 CD38 ARL4A PFKP PSMA2 PSMB2 HALLMARK_APICAL_JUNCTION%MSIGDB_C2%HALLMARK_APICAL_JUNCTION HALLMARK_APICAL_JUNCTION ACTN3 ACTN2 ICAM4 CX3CL1 CDH1 TMEM8B SHROOM2 MYL9 THY1 SORBS3 CRAT KCNH2 CD274 RASA1 NF1 ACTN1 ICAM1 ITGB1 ITGB4 COL16A1 SPEG CDH6 ACTG1 GNAI2 ACTA1 STX4 MYH9 YWHAH MVD IRS1 TNFRSF11B AKT3 VCAM1 GNAI1 CLDN9 CD86 ACTC1 BMP1 SDC3 TGFBI FBN1 INSIG1 SRC LAMC2 ITGA2 MMP2 DLG1 VCAN CDH11 LAMA3 SLIT2 ADAM9 LAMB3 VAV2 ICAM2 DMP1 ICAM5 ACTB TIAL1 GAMT ACTN4 CLDN6 CLDN5 CLDN4 CLDN8 SKAP2 GRB7 WNK4 MYL12B RRAS EPB41L2 TSPAN4 SYMPK RSU1 VASP CADM3 MAPK14 CDSN CADM2 PBX2 TJP1 PARVA ALOX15B CD209 COL9A1 WASL RAC2 DHX16 IKBKG LDLRAP1 CD34 CAP1 MAP4K2 VWF SYK RHOF KRT31 TUBG1 CLDN11 CLDN15 CLDN14 EXOC4 CLDN19 CLDN18 ARHGEF6 AMIGO1 AMIGO2 NEXN LIMA1 NRAP ADAM23 CTNNA1 MDK JUP FLNC MPZL1 MPP5 TAOK2 ZYX CLDN7 CRB3 CTNND1 MAPK13 INPPL1 GTF2F1 CDH8 ACTG2 CDH4 CDH3 PFN1 SIRPA NRTN SLC30A3 TSC1 PIK3R3 ADAM15 FSCN1 CERCAM DSC1 VCL DSC3 COL17A1 CNN2 PDZD3 PLCG1 MYH10 CD99 CD276 LAYN MSN CDK8 PTPRC ARPC2 ITGA10 CNTN1 PIK3CB ADRA1B PKD1 SGCE TRO ADAMTS5 MADCAM1 AMH ITGA3 EVL CDH15 ITGA9 MPZL2 NLGN3 PTEN NLGN2 ATP1A3 PARD6G NRXN2 FYB THBS3 PCDH1 NEGR1 HRAS BAIAP2 MAPK11 NFASC PPP2R2C PVRL4 PVRL3 PVRL2 PVRL1 HADH EGFR TRAF1 MMP9 PECAM1 B4GALT1 CALB2 NF2 PTK2 SHC1 JAM3 AKT2 HALLMARK_E2F_TARGETS%MSIGDB_C2%HALLMARK_E2F_TARGETS HALLMARK_E2F_TARGETS BARD1 PAICS STAG1 SUV39H1 CTCF KPNA2 BRCA2 ING3 TK1 DLGAP5 TCF19 HELLS TUBB SRSF2 KIF22 CIT RAD51C CKS2 PRIM2 PSMC3IP EXOSC8 PPP1R8 PMS2 GINS1 CDKN2A GINS3 GINS4 ATAD2 ORC2 RPA1 MRE11A MLH1 CENPE PHF5A TACC3 CENPM EIF2S1 NCAPD2 RAD1 TRIP13 SPC24 SPC25 DCLRE1B DSCC1 CSE1L BUB1B IPO7 PTTG1 CDC25A ILF3 MELK TIMELESS SNRPB DNMT1 PDS5B H2AFZ RAD51AP1 ORC6 CTPS1 UBR7 CBX5 HMGA1 NUP153 MCM4 PAN2 LSM8 KIF18B MCM5 DIAPH3 MCM6 UBE2S MCM2 UBE2T KIF4A MXD3 SRSF1 PSIP1 HMGB3 LMNB1 MYBL2 LBR POLE RFC1 TRA2B EED POLD2 SMC1A DCK MMS22L ESPL1 MCM3 LUC7L3 NOP56 BIRC5 PPM1D AURKB DUT RBBP7 E2F8 RRM2 NAP1L1 SPAG5 DEK DONSON HN1 RAD50 BRMS1L RQCD1 RAN TFRC CCNE1 MSH2 STMN1 MCM7 H2AFX DEPDC1 HMMR NASP PRPS1 TUBG1 RNASEH2A LIG1 TP53 CDK4 CDK1 POLA2 CDKN1A CDKN1B CDKN2C RFC3 RFC2 DCTPP1 TBRG4 UNG AK2 POLD3 NBN PLK4 PLK1 POLD1 RPA2 SSRP1 POLE4 ZW10 NUDT21 RPA3 CDC25B CDC20 CCNB2 MYC EZH2 NOLC1 TOP2A GSPT1 HMGB2 BRCA1 PRDX4 XRCC6 PA2G4 HNRNPD MTHFD2 ANP32E SYNCRIP XPO1 NME1 KIF2C PCNA AURKA WEE1 NUP107 POP7 USP1 CCP110 CKS1B SMC6 MKI67 SMC3 SMC4 PNN WDR90 CHEK2 RANBP1 CHEK1 TMPO TIPIN HUS1 DDX39A ASF1A ASF1B SLBP CDKN3 NUP205 CDCA3 PRKDC SHMT1 CDCA8 RACGAP1 RAD21 MAD2L1 LYAR HALLMARK_BILE_ACID_METABOLISM%MSIGDB_C2%HALLMARK_BILE_ACID_METABOLISM HALLMARK_BILE_ACID_METABOLISM CYP8B1 GNMT NEDD4 ALDH8A1 ACSL1 KLF1 AQP9 SLC29A1 APOA1 LIPE SCP2 BCAR3 RETSAT SULT2B1 AR NR0B2 PEX11A CROT ABCA3 NR1H4 FADS1 LCK PHYH SLC35B2 SLC23A2 LONP2 MLYCD GSTK1 DIO1 ACSL5 OPTN IDH1 DHCR24 EPHX2 GNPAT FADS2 SLC27A2 PRDX5 ISOC1 IDH2 ABCD2 ABCD3 SERPINA6 ABCD1 FDXR IDI1 PEX6 ALDH1A1 ALDH9A1 NR1I2 HSD17B4 HSD17B11 TTR RXRG HSD3B7 PEX13 PFKM CAT ABCA1 ABCA2 ATXN1 SOD1 AMACR PECR SLC23A1 CYP46A1 PEX26 GCLM NR3C2 NUDT12 ABCG8 DIO2 PIPOX CYP39A1 CYP27A1 CH25H SOAT2 RBP1 SLC22A18 PEX11G ABCG4 SLC27A5 HAO1 HACL1 ABCA5 ABCA6 ABCA4 ABCA9 ABCA8 BMP6 SULT1B1 PXMP2 SLCO1A2 TFCP2L1 PEX1 CYP7B1 PEX7 NPC1 EFHC1 AGXT PAOX AKR1D1 HSD17B6 CYP7A1 GC PEX16 PEX19 PNPLA8 HSD3B1 BBOX1 RXRA PEX12 HALLMARK_G2M_CHECKPOINT%MSIGDB_C2%HALLMARK_G2M_CHECKPOINT HALLMARK_G2M_CHECKPOINT BARD1 STAG1 SUV39H1 CTCF KPNA2 BRCA2 SRSF2 KIF22 CKS2 PRIM2 KPNB1 CUL1 G3BP1 HIF1A CENPE TACC3 PTTG1 CDC25A ILF3 PDS5B H2AFZ EFNA5 ORC6 RAD23B CCNA2 HMGA1 TFDP1 MCM5 MCM6 UBE2S MCM2 KIF4A SRSF1 DMD HMGB3 LMNB1 MYBL2 LBR POLE CDC45 TRA2B SMC1A ESPL1 BUB3 MCM3 BIRC5 MT2A AURKB HN1 TLE3 PML TGFB1 SAP30 UCK2 NOTCH2 ATF5 STMN1 AMD1 YTHDC1 H2AFX SQLE SMAD3 CENPA BCL3 HMMR ATRX MARCKS PAPD7 NASP SLC7A1 CDC6 MAPK14 GINS2 STIL CCNF SMC2 RPS6KA5 FBXO5 EWSR1 NUP98 KIF20B CDC7 TPX2 KIF11 HOXC10 KIF15 CHAF1A CHMP1A PBK SS18 PRMT5 UPF1 KIF23 INCENP MTF2 PAFAH1B1 DTYMK CDK4 HIRA PURA CDK1 WRN RAD54L POLA2 SRSF10 CASP8AP2 CENPF CCNT1 CASC5 ARID4A NUSAP1 CDKN1B HMGN2 SLC38A1 SLC7A5 LIG3 PRPF4B TRAIP CDKN2C NCL CUL5 TROAP CUL3 RASAL2 ORC5 ABL1 HSPA8 DR1 ODF2 UBE2C CBX1 FANCC FOXN3 NDC80 MNAT1 PTTG3P NUMA1 EXO1 WHSC1 TNPO2 RBM14 H2AFV SFPQ RBL1 NUP50 HIST1H2BK CDC27 KATNA1 E2F3 E2F4 POLQ EGF MEIS2 CUL4A MEIS1 E2F1 PRC1 CCND1 PLK4 PLK1 NEK2 RPA2 SETD8 HNRNPU CDC25B CDC20 CCNB2 SNRPD1 MYC SMARCC1 EZH2 NOLC1 TOP2A GSPT1 KIF5B HNRNPD DKC1 SYNCRIP XPO1 DBF4 KIF2C TTK ODC1 AURKA CKS1B BUB1 MKI67 SMC4 SLC12A2 CHEK1 TOP1 TMPO HUS1 DDX39A CDKN3 E2F2 RACGAP1 RAD21 MAD2L1 HALLMARK_MTORC1_SIGNALING%MSIGDB_C2%HALLMARK_MTORC1_SIGNALING HALLMARK_MTORC1_SIGNALING IFRD1 NAMPT PPIA PSMD14 RPA1 PGK1 SEC11A EIF2S2 COPS5 CDC25A MCM4 ETF1 MCM2 HSPD1 TES SERPINH1 RRM2 HSPE1 SLC6A6 STC1 FADS1 ACSL3 TFRC GAPDH BHLHE40 ATP2A2 PLOD2 TUBA4A DHCR24 TMEM97 TM7SF2 FADS2 RPN1 RDH11 STIP1 STARD4 HMGCS1 ASNS HSPA5 ENO1 IDI1 FAM129A HMGCR IGFBP5 DDIT4 EBP BTG2 NFIL3 SC5D SCD LDLR INSIG1 CYP51A1 SQLE CD9 LGMN ALDOA TPI1 SLC2A3 EGLN3 VLDLR CYB5B FGL2 AK4 PDAP1 GOT1 P4HA1 LTA4H SLC37A4 SKAP2 TUBG1 UBE2D3 SLA TBK1 IFI30 PNP PDK1 MAP2K3 DDIT3 CCNF TRIB3 SQSTM1 PIK3R3 XBP1 NMT1 DAPP1 ACACA HSP90B1 GBE1 ELOVL6 ELOVL5 CALR NFKBIB WARS GSK3B CDKN1A PSMA3 SLC7A5 SLC2A1 ACTR3 ACTR2 HK2 SORD ERO1L CXCR4 ACLY UNG SLC1A5 ADIPOR2 HMBS PLK1 IDH1 RIT1 GPI QDPR CTSC ITGB2 GTF2H1 SLC1A4 SLC9A3R1 ME1 PGM1 EPRS FDXR SLC7A11 RRP9 DHCR7 PPP1R15A USO1 GLRX ATP6V1D G6PD PSMG1 TCEA1 HSPA9 YKT6 HPRT1 ATP5G1 ADD3 IMMT PFKL LDHA M6PR PRDX1 GMPS MTHFD2 TXNRD1 PITPNB GSR ARPC5L SYTL2 PPA1 PSME3 MTHFD2L GCLC SHMT2 GLA CFP SSR1 PNO1 CCT6A DHFR MLLT11 PSMA4 EDEM1 PHGDH CACYBP UCHL5 CANX EEF1E1 TOMM40 GGA2 PSMB5 NFYC PSMC2 AURKA CCNG1 PSPH NUPR1 CTH PSMD12 FKBP2 PSMD13 CORO1A BUB1 SERP1 SDF2L1 HSPA4 SRD5A1 BCAT1 RAB1A NUFIP1 RAB1B ABCF2 UFM1 POLR3G DDX39A PSMC6 PSMC4 NUP205 PSAT1 HALLMARK_ALLOGRAFT_REJECTION%MSIGDB_C2%HALLMARK_ALLOGRAFT_REJECTION HALLMARK_ALLOGRAFT_REJECTION IL12B ICOSLG CDKN2A SPI1 HIF1A RPL9 IL27RA RPS19 IL12A RPL39 PRKCG KRT1 HLA-E IGSF6 CD79A ELANE ACHE CCR1 RPL3L CD40 CD28 AARS ITK CD3G STAB1 CD3E CD3D IKBKB CCR5 IL10 CCR2 IL11 RIPK2 IFNGR2 IL16 IL18 NCR1 TLR6 CCL13 CCL11 HLA-DMB TLR1 CXCR3 APBB1 CCL19 IL12RB1 NCF4 TLR3 LY75 TLR2 UBE2D1 CXCL13 SIT1 HLA-DOA HLA-DOB CD96 RPS9 TAP2 CARTPT CD8B HLA-A CD8A HLA-G SOCS5 DARS CRTAM GLMN THY1 CCL22 LY86 ST8SIA4 IL2 IL9 HLA-DRA HLA-DQA1 KLRD1 DEGS1 ABI1 EIF4G3 DYRK3 ITGAL MRPL3 SRGN EIF5A CSF1 RPS3A FGR EIF3J HLA-DMA ZAP70 IFNG STAT4 IL18RAP ELF4 ABCE1 MTIF2 EIF3D STAT1 CSK NOS2 TRAT1 GALNT1 TIMP1 IL4R CD4 CD7 IL15 IFNAR2 CD247 FCGR2B EIF3A B2M NLRP3 CAPG TGFB1 ICAM1 CCND3 CXCL9 PSMB10 FLNA FAS TAPBP TAP1 IRF7 LCP2 CCL7 CCL5 CCL2 WAS IL2RB CD40LG LYN IL13 INHBA CD86 IL6 GPR65 RARS GZMA GZMB SOCS1 CD80 IRF4 BCL3 LTB CCL4 IL2RA C2 GCNT1 ACVR2A MBL2 EREG F2 AKT1 LIF MAP3K7 PRKCB PTPN6 PF4 CTSS MAP4K1 IL4 IFNGR1 PTPRC IL7 JAK2 UBE2N IL1B WARS CD47 FASLG FYB GBP2 CD74 NCK1 TRAF2 LCK ETS1 CCND2 HCLS1 IL2RG EGFR CD1D TPD52 ITGB2 MMP9 PRF1 TNF INHBB F2R IRF8 BCL10 HDAC9 TGFB2 BRCA1 CFP NME1 CD2 BCAT1 NPM1 HALLMARK_IL6_JAK_STAT3_SIGNALING%MSIGDB_C2%HALLMARK_IL6_JAK_STAT3_SIGNALING HALLMARK_IL6_JAK_STAT3_SIGNALING CSF2RA STAT2 ACVR1B PTPN11 CCL7 CXCL10 IL1R2 IL6ST IL15RA IL1R1 EBI3 HMOX1 PIK3R5 STAM2 CD14 TNFRSF1B PIM1 TNF CCR1 CD36 IFNGR2 IL6 CBL ACVRL1 REG1A OSMR LEPR ITGA4 DNTT TYK2 IL12RB1 IL17RA IL9R ITGB3 MAP3K8 TLR2 PDGFC CXCL13 IL10RB PF4 CXCL1 PLA2G2A INHBE LTBR CRLF2 CD9 IRF1 SOCS1 IFNGR1 CD38 IL7 JUN IL1B GRB2 SOCS3 MYD88 CNTFR IL18R1 CSF3R IL3RA CSF1 IL17RB BAK1 LTB IRF9 CXCL3 IL13RA1 STAT1 STAT3 IL4R TNFRSF12A IFNAR1 CSF2RB IL2RA CD44 TNFRSF21 CSF2 TNFRSF1A CXCL11 TGFB1 CXCL9 A2M IL2RG PTPN1 PTPN2 HAX1 FAS HALLMARK_XENOBIOTIC_METABOLISM%MSIGDB_C2%HALLMARK_XENOBIOTIC_METABOLISM HALLMARK_XENOBIOTIC_METABOLISM LPIN2 AQP9 IL1R1 IGF1 CD36 ACP1 SERPINE1 NQO1 MT2A ID2 ETS2 SLC6A6 VTN GCNT2 CDA IGFBP1 UPP1 PSMB10 FBP1 ATP2A2 FAS SLC6A12 TMEM97 PPARD MAOA IGFBP4 HMOX1 ECH1 ABCD2 SERPINA6 GSTO1 EPHX1 FBLN1 AHCY ALDH9A1 CYP1A1 KYNU PC REG1A ALAS1 NINJ1 ARPP19 TMBIM6 SLC46A3 CYFIP2 ACSM1 SLC35B1 SPINT2 LONP1 PTGDS MCCC2 HES6 ENTPD5 UPB1 CYP27A1 MTHFD1 CYP2E1 EPHA2 CES1 GCH1 TPST1 ENPEP SLC35D1 SAR1B SLC22A1 FMO1 PROS1 ADH5 HACL1 TTPA ASL GSTM4 PMM1 CYP4F2 PYCR1 CDO1 CYP26A1 CYP2S1 CYP1A2 CSAD ARG2 SSR3 PTGR1 ANGPTL3 NPC1 GART CYP17A1 PGRMC1 SERTAD1 HSD17B2 XDH CCL25 MPP2 GSS AKR1C3 AKR1C2 FMO3 HRG DHRS1 GSTA3 GNMT COMT CNDP2 G6PC PGD FETUB PDLIM5 GSTT2 ABHD6 NDRG2 CYB5A CYP2C18 TKFC CYP2J2 GCKR MARCH6 HNF4A AP4B1 ESR1 LEAP2 TAT UGDH AOX1 MAN1A1 MBL2 ACP2 HGFAC RBP4 ABCC3 ABCC2 DHPS DDAH2 ACOX3 CRP CFB ITIH4 DDC LCAT NFS1 ATOH8 SLC12A4 HSD11B1 ACOX2 PINK1 BCAR1 POR JUP DCXR PLG RETSAT ITIH1 PTGES F10 APOE F11 NMT1 CROT PEMT ARG1 ELOVL5 TMEM176B FAH DHRS7 PAPSS2 TNFRSF1A PDK4 SLC1A5 TDO2 GABARAPL1 IDH1 ALDH3A1 ADH7 ACO2 CA2 TYR VNN1 ALDH2 CBR1 IRF8 ACOX1 ADH1C ETFDH DDT BPHL PTS TGFB2 KARS BLVRB CAT HPRT1 FABP1 CASP6 GSR RAP1GAP GCLC SHMT2 BCAT1 GAD1 PTGES3 SMOX HALLMARK_KRAS_SIGNALING_DN%MSIGDB_C2%HALLMARK_KRAS_SIGNALING_DN HALLMARK_KRAS_SIGNALING_DN BARD1 IL12B MEFV KRT1 PAX4 RYR1 HNF1A EDN1 LYPD3 GP1BA SKIL CHST2 CHRNG CKM CNTFR IFNG EDN2 PKP1 SEPP1 LFNG UGT2B17 NOS1 BMPR1B SHOX2 HSD11B2 CD40LG SGK1 IGFBP2 MYH7 CACNG1 ACTC1 BTG2 PTGFR SCGB1A1 COL2A1 CD80 IDUA SNN NR4A2 CYP39A1 ABCG4 TFCP2L1 KLK8 GAMT CLDN8 SERPINB2 FGFR3 IFI44L RSAD2 SLC30A3 FGF22 MX1 KRT13 PNMT KRT15 CALML5 VPREB1 TCL1A SYNPO GTF3C5 LGALS7 EGF PDK2 EPHA5 KRT4 CELSR2 SLC6A14 ENTPD7 KRT5 SOX10 SCN10A CLPS KCNQ2 KLK7 SLC5A5 C5 KCNMB1 KCNN1 SPTBN2 DTNB ARPP21 GP2 MTHFR ATP4A TG AKR1B10 ZC2HC1C STAG3 H2AFY2 PCDHB1 KLHDC8A CD207 ADCK3 CPEB3 GPR19 RYR2 TENM2 SERPINA10 PTPRJ SLC6A3 CCR8 KCND1 SPHK2 FSHB ATP6V1B1 COPZ2 PAX3 TEX15 MYOT TFF2 CLDN16 GPRC5C SLC29A3 ZNF112 SPRR3 ALOX12B CCDC106 ABCB11 NTF3 FAM46C RIBC2 GPR3 NR6A1 YPEL1 BRDT TGFB2 CLSTN3 ARHGDIG IRS4 PARK2 TGM1 NUDT11 CAPN9 SLC16A7 YBX2 CPA2 CDKAL1 THNSL2 EDAR MSH5 SIDT1 KMT2D CALCB CPB1 KCNE2 CACNA1F FGGY PRODH SLC38A3 TFAP2B DCC CCDC132 AMBN ZBTB16 HTR1D HTR1B FGF16 IL5 CCNA1 GDNF CYP11B2 TLX1 THRB MAST3 OXT MFSD6 EFHD1 INSL5 TSHB TAS2R4 GRID2 CAMK1D PROP1 NGB UPK3B WNT16 TNNI3 ADRA2C SSTR4 ITGB1BP2 CDH16 ITIH3 SMPX NPY4R PLAG1 P2RY4 NRIP2 PDE6B SLC25A23 SNCB SLC12A3 TCF7L1 DLK2 P2RX6 NPHS1 MYO15A MAGIX ASB7 RGS11 PDCD1 HALLMARK_MITOTIC_SPINDLE%MSIGDB_C2%HALLMARK_MITOTIC_SPINDLE HALLMARK_MITOTIC_SPINDLE BRCA2 DLGAP5 BIN1 KIF22 CENPE YWHAE SPTAN1 SPTBN1 KIF4A SHROOM2 APC LMNB1 RFC1 GSN SMC1A ESPL1 BIRC5 ABI1 RAPGEF6 OPHN1 RASA1 NF1 FLNA TUBA4A TRIO UXT PREX1 PPP4R2 ARFIP2 KIFAP3 CDK5RAP2 MAP1S CSNK1D CD2AP BCR EZR BCL2L11 LLGL1 PIF1 ABR STK38L CEP72 MYH9 CEP192 NET1 CCDC88A ANLN SASS6 CRIPAK NOTCH2 CEP57 ARHGAP5 ARHGAP4 AKAP13 PCM1 CNTRL DYNLL2 CTTN CDC42EP4 DOCK4 ARHGEF3 CDC42EP2 CDC42EP1 ARHGEF2 KPTN ARHGEF7 RAPGEF5 MAPRE1 ARF6 RABGAP1 STAU1 TUBD1 FGD4 FGD6 RICTOR PCNT DYNC1H1 PCGF5 RANBP9 SORBS2 MYO9B CENPJ ALMS1 RAB3GAP1 CEP250 KNTC1 RALBP1 CEP131 MID1 CLIP2 CLIP1 ARL8A TUBGCP2 PXN KLC1 KIF3B KIF3C DLG1 ECT2 MARK4 TBCD ARHGAP29 HOOK3 ARHGAP27 SSH2 TUBGCP5 TUBGCP6 TUBGCP3 CNTROB MAP3K11 PKD2 SEPT9 CAPZB NCK2 TLK1 ARHGEF11 SUN2 PLEKHG2 ARAP3 SHROOM1 CKAP5 LATS1 MYO1E ARHGAP10 ALS2 PALLD ATG4B MARCKS SOS1 KATNB1 HDAC6 CDC42 CYTH2 WASF1 WASF2 CLASP1 MID1IP1 RASA2 ACTN4 EPB41L2 PDLIM5 CDC42BPA WASL RHOF ITSN1 BCAR1 ARHGDIA TAOK2 TIAM1 FBXO5 TSC1 KIF20B FSCN1 TPX2 KIF11 VCL KIF15 MYH10 KIF23 SAC3D1 INCENP PAFAH1B1 CDK1 CENPF NUSAP1 RASAL2 ABL1 NCK1 FLNB NDC80 FARP1 NUMA1 CDC27 KATNA1 SYNPO PRC1 PLK1 NEK2 KIF1B EPB41 DST LRPPRC CCNB2 DOCK2 RHOT2 NIN ARFGEF1 TOP2A KIF5B GEMIN4 ROCK1 NEDD9 KIF2C TTK AURKA ARHGEF12 BUB1 SMC3 SMC4 RACGAP1 HALLMARK_P53_PATHWAY%MSIGDB_C2%HALLMARK_P53_PATHWAY HALLMARK_P53_PATHWAY RAD51C CDKN2A VDR GNB2L1 TNFSF9 SPHK1 IL1A HBEGF JUN PPM1D GADD45A FUCA1 VAMP8 SDC1 CD82 PDGFA NOTCH1 JAG2 AK1 S100A4 UPP1 PTPRE TGFB1 MXD1 CCND3 PLXNB2 NDRG1 ITGB4 FAS TAP1 CTSD ACVR1B SAT1 RRAD TSC22D1 CDK5R1 HMOX1 CDH13 EPHX1 ABCC5 ATF3 TNNI1 TPD52L1 DDIT4 BTG2 BTG1 CD81 IER5 NINJ1 TGFA TCHH PLK2 SOCS1 RNF19B CYFIP2 BAK1 FAM162A EPHA2 CDKN2B SLC35D1 DRAM1 PMM1 ISCU KLK8 RXRA ST14 ALOX15B PERP ABAT LIF DCXR RETSAT IFI30 DDIT3 TRIB3 TP53 SLC19A2 POM121 TRAFD1 PROCR XPC SFN VWA5A ADA FOS CDKN1A SEC61A1 CCNK RRP8 RPL36 HRAS POLH BAIAP2 TP63 RPS12 DNTTIP2 PRKAB1 TM4SF1 ANKRA2 CDKN2AIP NHLH2 RALGDS HEXIM1 DDB2 PLK3 OSGIN1 TCN2 CSRNP2 IKBKAP HINT1 CCND2 KIF13B CTSF ZNF365 PRMT2 AEN SERPINB5 RAP2B TAX1BP3 PVT1 RPS27L NOL8 MKNK2 SERTAD3 WWP1 BLCAP DEF6 HIST3H2A LDHB KRT17 STEAP3 DGKA TM7SF3 SESN1 NUDT15 PHLDA3 FBXW7 CGRRF1 BMP2 MAPKAPK3 ABHD4 ZFP36L1 IRAK1 ZMAT3 CLCA2 IP6K2 S100A10 SP1 MDM2 FGF13 MXD4 ADCK3 RAD9A LRMP TRIAP1 PITPNC1 PIDD1 GM2A HSPA4L H2AFJ HIST1H1C GPX2 APAF1 FDXR RHBDF2 IER3 WRAP73 INHBB TRAF4 SLC7A11 CEBPA F2R HDAC3 GLS2 ERCC5 EI24 SLC3A2 RCHY1 TXNIP PPP1R15A RAB40C RGS16 EPS8L2 TPRKB PTPN14 STOM TOB1 TSPYL2 CASP1 FOXO3 KLF4 ZBTB16 PCNA CCNG1 NUPR1 BAX CCP110 RPL18 RB1 APP CALCIUM SIGNALING IN THE CD4+ TCR PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CALCIUM SIGNALING IN THE CD4+ TCR PATHWAY Calcium signaling in the CD4+ TCR pathway CALM3 CALM1 CALM2 CSF2 FASLG AKAP5 PTGS2 CABIN1 CHP1 PRKACA JUNB BATF3 JUN POU2F1 NFATC3 NFATC2 NFATC1 FOS IL2 FKBP1A FOSL1 IL4 RCAN1 IL3 CD40LG IFNG RCAN2 IL2RA REGULATION OF NUCLEAR SMAD2 3 SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF NUCLEAR SMAD2 3 SIGNALING Regulation of nuclear SMAD2 3 signaling ATF2 CDKN1A CITED1 ITGB5 SERPINE1 LAMC1 NR3C1 MED15 SIN3B SIN3A HNF4A MYC EP300 AKT1 SNIP1 TGIF1 NCOA1 IL10 PIAS4 PIAS3 NCOA2 MEF2C TGIF2 FOXH1 TFE3 RUNX3 RUNX2 RUNX1 SAP30 JUN KAT2B AR KAT2A TFDP1 FOS NCOR1 RBL1 CREB1 MYOD1 IRF7 ATF3 DLX1 HDAC2 CEBPB CBFB HDAC1 CTBP1 MAX FOXG1 GATA3 FOXO4 FOXO3 FOXO1 RBBP4 GSC SAP18 E2F4 RBBP7 NKX2-5 IGHA1 E2F5 SKIL SMAD2 HSPA8 ZBTB17 CDKN2B CREBBP SMAD4 SMAD3 IFNB1 VDR ESR1 SMAD7 SKI IL5 COL1A2 CDK4 SP1 CDK2 SP3 TCF3 DCP1A IL23-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL23-MEDIATED SIGNALING EVENTS IL23-mediated signaling events CXCL9 IL23R IL24 CXCL1 ALOX12B PIK3R1 CD3E MPO TNF RELA SOCS3 IL18RAP STAT4 CCL2 IL12B JAK2 IL12RB1 STAT5A NOS2 ITGA3 STAT1 STAT3 IL18 IL19 TYK2 NFKB1 NFKBIA IL6 CD4 PIK3CA IL23A IL1B IL17F IL18R1 IL17A IL2 IFNG SUMOYLATION BY RANBP2 REGULATES TRANSCRIPTIONAL REPRESSION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SUMOYLATION BY RANBP2 REGULATES TRANSCRIPTIONAL REPRESSION Sumoylation by RanBP2 regulates transcriptional repression HDAC4 RANBP2 UBE2I XPO1 SUMO1 MDM2 RANGAP1 PIAS2 RAN PIAS1 HDAC1 OSTEOPONTIN-MEDIATED EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%OSTEOPONTIN-MEDIATED EVENTS Osteopontin-mediated events PIK3R1 RELA ROCK2 ITGB3 ILK CDC42 MAPK8 PLAU SPP1 PIP5K1A PTK2B MAPK1 ITGAV NFKB1 RAC1 NFKBIA MAPK3 VAV3 MAP3K1 PIK3CA GSN SYK CHUK MMP2 MMP9 RHOA MAP3K14 CD44 BCAR1 JUN FOS ALK1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALK1 SIGNALING EVENTS ALK1 signaling events ACVRL1 BMPR2 ARRB2 ACVR1 SMAD1 TGFB1 TGFB3 CAV1 GDF2 SMAD9 INHBA SMAD5 ACVR2B ACVR2A TGFBR1 TGFBR2 PPP1CA TLX2 SMAD4 ID1 CSNK2B ENG SMAD7 MAPK1 MAPK3 FKBP1A SIGNALING EVENTS REGULATED BY RET TYROSINE KINASE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS REGULATED BY RET TYROSINE KINASE Signaling events regulated by Ret tyrosine kinase GAB1 PTPN11 GFRA1 FRS2 PRKCA PTK2 DOK1 DOK4 GDNF DOK5 RASA1 DOK6 PIK3R1 GRB2 SOS1 CRK MAPK8 MAPK1 RAC1 MAPK3 PIK3CA RHOA PRKACA BCAR1 JUN RET GRB7 IRS1 SHC1 CREB1 SRC PXN IRS2 RAP1A GRB10 HRAS PDLIM7 NCK1 SYNDECAN-1-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-1-MEDIATED SIGNALING EVENTS Syndecan-1-mediated signaling events FGF19 COL4A4 COL7A1 COL5A2 COL4A3 COL6A1 COL4A6 SDC1 TGFB1 COL4A5 COL6A3 HPSE FGFR4 PPIB FGFR3 MET COL1A2 MAPK1 MAPK3 MMP9 PRKACA LAMA5 COL11A1 COL11A2 SDCBP CCL5 BSG FGF23 MMP7 MMP1 HGF CASK COL1A1 COL3A1 COL2A1 COL5A1 COL4A1 COL6A2 REGULATION OF RAS FAMILY ACTIVATION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RAS FAMILY ACTIVATION Regulation of Ras family activation CALM3 RIN1 CALM1 SOS2 CALM2 PRKCA RASA1 GRB2 SOS1 CAMK2B RASGRF2 RASGRF1 RASAL1 RASGRP2 RASGRP1 PRKCZ RASGRP4 RASGRP3 RABGEF1 LGALS3 NRAS LGALS1 SYNGAP1 RRAS PLCE1 PRKCB PRKCE DAB2IP RASA4 HRAS RASA2 NF1 KRAS AURORA C SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AURORA C SIGNALING Aurora C signaling INCENP AURKC AURKB IL4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL4-MEDIATED SIGNALING EVENTS IL4-mediated signaling events ARG1 GTF3A OPRM1 FCER2 DOK2 IRF4 LTA IGHE RETNLB CCL11 ALOX15 THY1 PIK3R1 CBL IL2RG SOCS1 STAT6 CCL17 SOCS3 SOCS5 STAT5B EGR2 HMGA1 MAPK14 JAK2 PARP14 MTOR STAT5A AICDA SELP RPS6KB1 BCL6 FES PTPN6 BCL2L1 CCL26 AKT1 PIK3CA IL10 IRS1 SHC1 IL4 IRS2 CD40LG CEBPB GRB2 ITGB3 IL5 COL1A2 SP1 PIGR SPI1 ETS1 IGHG1 MYB IL13RA2 COL1A1 MYBL1 JAK3 IL13RA1 JAK1 IL4R SHP2 SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SHP2 SIGNALING SHP2 signaling PIK3R1 IL2RG JAK2 STAT1 IL6 PIK3CA PRKACA NRAS IRS1 IL2 SHC1 HRAS IFNG IL2RA KRAS GAB1 PTPN11 ARHGAP35 IGF1R FRS2 KDR IL6R PDGFRB MAP2K1 MAP2K2 IFNGR1 LMO4 GAB2 NGF GRB2 FRS3 SOS1 LCK IL6ST RAF1 SDC2 GNAI3 PDGFB MLLT4 GNAI1 EGFR NTF4 NTF3 PAG1 NTRK1 NTRK2 ANGPT1 EGF NOS3 BDNF NTRK3 VEGFA IL2RB TEK RHOA JAK3 JAK1 IL2 SIGNALING EVENTS MEDIATED BY PI3K%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL2 SIGNALING EVENTS MEDIATED BY PI3K IL2 signaling events mediated by PI3K CALM3 PTPN11 CALM1 CALM2 FOXO3 GAB2 PIK3R1 GRB2 IL2RG SOS1 LCK RELA MTOR RPS6KB1 BCL2L1 MYC NFKB1 AKT1 RAC1 IL2RB PIK3CA UGCG TERT PRKCZ SMPD1 E2F1 HSP90AA1 RPS6 BCL2 EIF3A IL2 SHC1 MYB JAK3 JAK1 IL2RA NOTCH-MEDIATED HES HEY NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NOTCH-MEDIATED HES HEY NETWORK Notch-mediated HES HEY network CTBP1 KDR RB1 CAMK2D CREBBP CDKN1B NOTCH1 JAK2 MAML2 KDM1A MAML1 GATA6 TWIST1 GATA4 STAT3 RBPJ ASCL1 GATA1 HIF1A EP300 GHR YY1 TCF3 HEY1 CD4 BGLAP NCOA1 HEY2 RBBP8 HES1 SPEN HES6 TLE1 PARP1 GAA ARNT RUNX2 NCOR2 PTF1A E2F1 NEUROG3 AR NCOR1 MYOD1 MYB RCAN1 HDAC1 PLK1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLK1 SIGNALING EVENTS PLK1 signaling events PRC1 GORASP1 CDK1 KIF20A KIZ INCENP SPC24 TPT1 ROCK2 RAB1A ERCC6L BUB1B AURKA CDC14B PPP2CA GOLGA2 CDC20 PPP1CB PAK1 CCNB1 FZR1 SGOL1 PPP2R1A CLSPN RHOA FBXO5 ECT2 BTRC BUB1 NINL CENPU NUDC PPP1R12A BORA FBXW11 ODF2 PLK1 CDC25C TUBG1 NDC80 CDC25B TPX2 CENPE WEE1 STAG2 KIF2A INTEGRIN FAMILY CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTEGRIN FAMILY CELL SURFACE INTERACTIONS Integrin family cell surface interactions ITGB5 ITGB3 ITGA3 ITGB1 ITGAM ITGB4 ITGAV ITGB2 ITGA2B ITGAE ITGAL ITGAX ITGB8 ITGB7 ITGB6 ITGA4 ITGA2 ITGA1 ITGAD ITGA10 ITGA11 ITGA8 ITGA7 ITGA6 ITGA5 ITGA9 BARD1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BARD1 SIGNALING EVENTS BARD1 signaling events PCNA PRKDC UBE2D3 BRCA1 UBE2L3 CSTF1 TOPBP1 NBN BARD1 XRCC6 FANCL XRCC5 FANCA MRE11A FANCC FANCE FANCG FANCF RAD50 CDK2 RAD51 CCNE1 FANCD2 EWSR1 ATM RBBP8 TP53 ATR S1P5 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P5 PATHWAY S1P5 pathway S1PR5 GNAI2 GNAI3 GNAI1 RHOA GNAO1 GNAZ GNA12 TRK RECEPTOR SIGNALING MEDIATED BY PI3K AND PLC-GAMMA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TRK RECEPTOR SIGNALING MEDIATED BY PI3K AND PLC-GAMMA Trk receptor signaling mediated by PI3K and PLC-gamma GAB1 FOXO3 YWHAE GSK3B YWHAB CAMK2A AGAP2 YWHAQ PIK3R1 CCND1 NGF GRB2 EPB41L1 SOS1 SFN PLCG1 YWHAG YWHAH EGR1 TRPC3 BAD PDPK1 PRKCD TRPV1 STAT5A YWHAZ CAMK4 NTRK1 AKT1 PIK3CA NRAS SHC1 CREB1 SRC HRAS KRAS IL12 SIGNALING MEDIATED BY STAT4%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL12 SIGNALING MEDIATED BY STAT4 IL12 signaling mediated by STAT4 TGFB1 CD3E IL18RAP STAT4 CREBBP MAPK8 STAT3 IL18 CD4 IL18R1 CD86 CD80 PRF1 CD3G CD3D MAPK9 TBX21 JUN IL13 ETV5 IRF1 CD28 HLA-DRA FOS CD247 IL2 HLA-DRB1 PIAS2 IFNG IL2RA AURORA B SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AURORA B SIGNALING Aurora B signaling KIF20A INCENP AURKC AURKB RASA1 CUL3 CDCA8 NCAPG PEBP1 KLHL13 CENPA SMC4 NCAPH SMC2 MYLK PPP1CC AURKA RACGAP1 STMN1 EVI5 NPM1 CBX5 NSUN2 KIF23 PPP2R5D KLHL9 SGOL1 PSMA3 DES RHOA NCL BIRC5 TACC1 KIF2C BUB1 NCAPD2 VIM NDC80 S1P4 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P4 PATHWAY S1P4 pathway MAPK3 RHOA GNAO1 GNAZ GNA12 PLCG1 S1PR5 GNAI2 GNAI3 GNA13 S1PR4 GNAI1 CDC42 MAPK1 NETRIN-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NETRIN-MEDIATED SIGNALING EVENTS Netrin-mediated signaling events TRIO PITPNA WASL PTK2 NTN1 FYN MAP2K1 YES1 MAP2K2 CAMK2A UNC5A AGAP2 MYO10 DAPK1 PIK3R1 UNC5B DCC UNC5C PLCG1 MAP1B ELMO1 DOCK1 CDC42 MAPK1 RAC1 MAPK3 PIK3CA PAK1 RHOA BCAR1 SRC NCK1 CLASS IB PI3K NON-LIPID KINASE EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CLASS IB PI3K NON-LIPID KINASE EVENTS Class IB PI3K non-lipid kinase events PDE3B PIK3CG MAP2K1 PIK3R6 MAPK1 C-MYB TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%C-MYB TRANSCRIPTION FACTOR NETWORK C-MYB transcription factor network MYF6 TAB2 TAB1 ADA CCND1 MPO CDKN1A CDKN1B SIN3A MYC GATA1 EP300 CD4 PIAS3 HES1 PTGS2 NRAS NCOR1 UBE2I MYOD1 HRAS CEBPB KRAS GATA3 SLC25A3 LECT2 CLTA YEATS4 HSPA8 ETS2 PPP3CA CA1 CREBBP TRIM28 CASP6 ANPEP TOM1 PIM1 RAG2 CD34 SKI MAP3K7 PTCRA COL1A2 H2AFZ PAX5 SP1 SND1 CCNA1 MAF ADORA2B TFEC KIT MCM4 CCNB1 PRTN3 ZFPM1 PPID MAD1L1 BIRC3 CSF1R CEBPA COPA CEBPD LEF1 IQGAP1 NLK MAT2A BCL2 WNT1 ELANE SPI1 ZFHX3 ETS1 GSTM1 CBX4 MYB CDKN2A ATP2B1 LYZ SMARCA2 HIPK2 KITLG CDK6 EPHB FORWARD SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHB FORWARD SIGNALING EPHB forward signaling WASL PTK2 MAP2K1 RASA1 PIK3R1 GRB2 CRK ROCK1 ITSN1 EFNA5 KALRN EFNB2 CDC42 RAP1B EFNB1 EFNB3 EPHB2 EPHB1 EPHB4 MAPK1 EPHB3 MAP4K4 RAC1 DNM1 MAPK3 TF SYNJ1 PIK3CA PAK1 NRAS GRB7 SHC1 RRAS SRC PXN RAP1A HRAS NCK1 KRAS FAS (CD95) SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FAS (CD95) SIGNALING PATHWAY FAS (CD95) signaling pathway RIPK1 IKBKG FADD BID MAP2K7 MAP2K6 RFC1 CFLAR MAPK10 MAPK11 BTK FAS PIK3R1 EZR BIRC2 PDPK1 MAPK14 MAPK8 AKT1 MAP3K1 PIK3CA SYK CHUK FASLG BIRC3 MAPK9 SMPD1 SRC CLTC FAIM2 PIK3CB IKBKB CASP8 CASP10 CASP3 PLK2 AND PLK4 EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLK2 AND PLK4 EVENTS PLK2 and PLK4 events PLK4 PLK2 CERAMIDE SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CERAMIDE SIGNALING PATHWAY Ceramide signaling pathway RIPK1 FADD BID MAP2K1 MAP2K2 TNF RELA RAF1 BAD PRKCD MAPK8 EGF MYC MAPK1 MAP4K4 NFKB1 AKT1 NFKBIA MAPK3 MAP3K1 ASAH1 TRADD PDGFA SMPD3 BAG4 AIFM1 CTSD BIRC3 MAP2K4 KSR1 CRADD PRKCZ SMPD1 SPHK2 EIF2AK2 PAWR TRAF2 TNFRSF1A BCL2 PRKRA MADD CYCS BAX CASP8 ATYPICAL NF-KAPPAB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATYPICAL NF-KAPPAB PATHWAY Atypical NF-kappaB pathway NFKB1 NFKBIA PIK3CA ARRB2 SYK PIK3R1 BTRC LCK RELA MAPK14 SRC BCL3 REL IKBKB ALPHA-SYNUCLEIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA-SYNUCLEIN SIGNALING Alpha-synuclein signaling FYN YES1 LCK BLK MAOB PARK7 PLD1 UBE2L3 SLC6A3 PARK2 BAD KLK6 PLD2 PRKCD UCHL1 GRK5 SNCA LYN TOR1A CSNK2A1 FGR PTK2B HCK TH STUB1 PLCB2 SYK PPP2R5D FKBP1A SRC SIGNALING EVENTS MEDIATED BY PTP1B%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY PTP1B Signaling events mediated by PTP1B FYN YES1 CAV1 PIK3R1 BLK SOCS3 STAT5B JAK2 STAT5A LYN STAT3 FGR HCK TYK2 AKT1 ITGA2B PIK3CA IRS1 CSF1 SHC1 CSN2 SRC PRL YBX1 CDH2 LEPR CAPN1 PRLR TXN INS CSK PTPN1 INSR FER FCGR2A PDGFRB DOK1 TRPV6 LEP NOX4 SPRY2 LAT GRB2 LCK CRK PDGFB EGFR ITGB3 EGF RHOA CSF1R BCAR1 RHOA SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RHOA SIGNALING PATHWAY RhoA signaling pathway F2RL2 MAP2K6 EZR PLD1 ATF2 ROCK1 CDKN1B ROCK2 PLD2 CDC42 MAPK8 PIP5K1A ITGB1 SRF PTEN CYR61 SLC9A1 PARD6A RHOA CFL1 PIP5K1B MAP2K4 PIP5K1C SCAI PRKCZ SH3GL2 MAP2K3 JUN LIMK2 PPP1R12A MKL1 RDX LIMK1 MSN FOS MAPK12 CIT DIAPH1 SLC9A3 ACTA1 MYL2 PKN2 PKN1 TLN1 VCL SYNDECAN-2-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-2-MEDIATED SIGNALING EVENTS Syndecan-2-mediated signaling events FGF19 TGFB1 RASA1 CXCL8 FGFR4 TNFRSF13B EZR EPB41 FGFR3 LAMA1 LAMA3 KNG1 SDC2 CAV2 TRAPPC4 FN1 GNB2L1 PRKCD MAPK8 EPHB2 ITGB1 MAPK1 MAPK3 CSF2 MMP2 ITGA2 RHOA PRKACA SDCBP FGF23 BAX SRC CASK HRAS NF1 CASP3 RAS SIGNALING IN THE CD4+ TCR PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RAS SIGNALING IN THE CD4+ TCR PATHWAY Ras signaling in the CD4+ TCR pathway MAPK3 PRKCA MAP2K1 RAF1 NRAS FOS PRKCB BRAF ELK1 MAP3K8 PTPN7 HRAS MAPK1 KRAS ATF-2 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATF-2 TRANSCRIPTION FACTOR NETWORK ATF-2 transcription factor network ARG1 CXCL8 CCND1 SOCS3 RB1 ATF2 MAPK14 NOS2 BCL2L1 TH EP300 IL6 IL23A HES1 JUNB MAPK9 JUN POU2F1 HRK ACHE CSRP2 FOS DUSP10 KAT5 CREB1 RUVBL2 DUSP5 PDGFRA ATF3 H2AFY DUSP1 DUSP8 IFNG SERPINB5 CBFB NF1 CCNA2 DDIT3 INS JDP2 PPARGC1A TGFB2 PRKCA JUND HBG2 COL24A1 GADD45A SELE MAPK11 BRCA1 CUL3 ESR1 MAPK8 PLAU CDK4 MAPK1 MAPK3 MMP2 BCL2 EPHA FORWARD SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHA FORWARD SIGNALING EPHA forward signaling FYN YES1 CBL LCK CRK BLK PLCG1 ROCK1 EFNA5 PIK3CG PIK3R6 CRKL LYN EPHA5 EPHA4 EPHA7 EPHA6 FGR ARHGEF15 HCK EPHA8 VAV2 EFNA1 EFNA3 VAV3 EFNA2 CDK5 EPHA1 EPHA3 NGEF EPHA2 RHOA SRC SIGNALING EVENTS MEDIATED BY HDAC CLASS I%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HDAC CLASS I Signaling events mediated by HDAC Class I HDAC10 HDAC11 CHD4 CHD3 MBD3L2 TNF SMG5 PRMT5 RELA SIRT4 SIRT5 SIRT6 SIRT7 SIRT1 SIRT2 SIRT3 WDR77 PPARG FKBP3 HDAC5 SIN3B HDAC3 STAT3 SIN3A GATA2 HDAC8 GATA1 NR2C1 EP300 HDAC9 NFKB1 HDAC6 NFKBIA YY1 HDAC7 MTA2 MBD3 SMURF1 MBD2 GATAD2B GATAD2A TFCP2 MXD1 PRKACA NCOR2 SAP30 KAT2B HDAC4 NCOR1 RANBP2 UBE2I XPO1 SUMO1 RANGAP1 HDAC2 RAN HDAC1 MAX RBBP4 SAP18 RBBP7 CREBBP SMAD7 ZFPM1 BTRC TNFRSF1A FOXO FAMILY SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXO FAMILY SIGNALING FoxO family signaling RALA RALB ZFAND5 FOXO4 BCL2L11 FOXO3 SKP2 YWHAE FOXO1 CSNK1G3 USP7 GADD45A YWHAB G6PC MAPK10 CSNK1A1 CSNK1D YWHAQ CSNK1E FBXO32 SOD2 SFN RBL2 CAT YWHAG CTNNB1 YWHAH SGK1 CSNK1G2 CSNK1G1 CREBBP CDKN1B SIRT1 YWHAZ MAPK8 BCL6 EP300 CDK2 AKT1 CCNB1 CHUK FASLG MAPK9 KAT2B PLK1 XPO1 IKBKB RAN ARF6 TRAFFICKING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF6 TRAFFICKING EVENTS Arf6 trafficking events INS EXOC4 RALA AGTR1 CPE EXOC3 EXOC6 EXOC5 EXOC2 VAMP3 ARF6 EXOC1 CTNNB1 PLD1 PLD2 ITGA3 ITGB1 ITGAV ITGA4 ITGA2 ITGA1 PIP5K1C ITGA10 ITGA11 CTNND1 ITGA8 ASAP2 ITGA7 SLC2A4 ITGA6 ADRB2 ITGA5 KLC1 ITGA9 CDH1 CTNNA1 SPAG9 EXOC7 AVPR2 CLTC MAPK8IP3 TSHR SCAMP2 NME1 DNM2 ACAP1 BIN1 SPHINGOSINE 1-PHOSPHATE (S1P) PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SPHINGOSINE 1-PHOSPHATE (S1P) PATHWAY Sphingosine 1-phosphate (S1P) pathway GNAO1 GNAZ SPHK2 GNA12 S1PR5 GNAI2 GNAI3 GNA13 S1PR4 ABCC1 GNAI1 SPHK1 SGPP1 GNA14 GNA15 SGPL1 GNAQ GNA11 S1PR1 S1PR3 S1PR2 CLASS I PI3K SIGNALING EVENTS MEDIATED BY AKT%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CLASS I PI3K SIGNALING EVENTS MEDIATED BY AKT Class I PI3K signaling events mediated by Akt FOXO4 FOXO3 YWHAE FOXO1 GSK3B YWHAB YWHAQ SFN PRKDC YWHAG RAF1 YWHAH BAD CDKN1A CDKN1B PDPK1 MTOR YWHAZ BCL2L1 AKT1 CHUK GSK3A MAPKAP1 CASP9 AKT2 PRKACA AKT3 MLST8 RICTOR SLC2A4 KPNA1 HSP90AA1 MAP3K5 TBC1D4 SRC E-CADHERIN SIGNALING IN THE NASCENT ADHERENS JUNCTION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E-CADHERIN SIGNALING IN THE NASCENT ADHERENS JUNCTION E-cadherin signaling in the nascent adherens junction CYFIP2 NCKAP1 WASF2 AP1M1 JUP KLHL20 ENAH TJP1 ARF6 TIAM1 DLG1 CTTN PIK3R1 CCND1 ABI1 RAPGEF1 CRK CTNNB1 MLLT4 CDC42 RAP1B VAV2 AKT1 RAC1 ITGAE PIK3CA ITGB7 RHOA PIP5K1C CTNND1 IQGAP1 CDH1 CTNNA1 SRC RAP1A NME1 SIGNALING EVENTS MEDIATED BY THE HEDGEHOG FAMILY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY THE HEDGEHOG FAMILY Signaling events mediated by the Hedgehog family STIL DHH AKT1 HHIP TGFB2 PTCH1 PTCH2 PIK3CA IHH ARRB2 LRP2 PTHLH GLI2 SHH HHAT SMO PIK3R1 ADRBK1 BOC GAS1 CDON LRPAP1 POLO-LIKE KINASE SIGNALING EVENTS IN THE CELL CYCLE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%POLO-LIKE KINASE SIGNALING EVENTS IN THE CELL CYCLE Polo-like kinase signaling events in the cell cycle PLK4 PLK3 PLK2 PLK1 VISUAL SIGNAL TRANSDUCTION: CONES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VISUAL SIGNAL TRANSDUCTION: CONES Visual signal transduction: Cones SLC24A2 GUCY2D PDE6H GUCA1B GUCA1A GUCA1C ARR3 GUCY2F RPE65 GRK1 GNGT2 GNAT2 RDH12 RGS9BP GRK7 PDE6C GNB3 CNGB3 RDH5 LRAT CNGA3 GNB5 RGS9 RAC1 SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RAC1 SIGNALING PATHWAY RAC1 signaling pathway ATF2 MAPK14 STAT5A STAT3 PLCB2 MAPK9 JUN NCF1 NCF2 ARPC1B BRK1 ARHGAP5 ARHGDIA ACTR3 ACTR2 CYBB CYBA CYFIP2 NOXO1 NCKAP1 IQGAP3 WASF1 WASF2 MAP2K7 PAK2 MAP2K6 ARPC4 ARPC5 BAIAP2 ABI2 ARPC2 ARPC3 NOXA1 ABI1 MAP3K11 NOX1 CRK CTNNB1 MAPK8 PIP5K1A RACGAP1 RAC1 MAP3K1 PAK1 CFL1 MAP2K4 PIP5K1B PIP5K1C BCAR1 MAP2K3 IQGAP1 CDH1 LIMK1 CTNNA1 REGULATION OF CDC42 ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF CDC42 ACTIVITY Regulation of CDC42 activity PLCG1 ITSN1 CDC42 RACGAP1 VAV2 DOCK6 VAV3 ITSN2 BCAR3 ARHGEF25 DOCK9 NGEF ARHGAP1 ARHGAP17 FGD1 DOCK10 DOCK11 MCF2L GIT1 FARP2 RALBP1 MCF2 ARHGEF9 DNMBP APC SPATA13 ARHGEF7 ARHGEF6 ARHGDIA NME1 HIF-2-ALPHA TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HIF-2-ALPHA TRANSCRIPTION FACTOR NETWORK HIF-2-alpha transcription factor network KDR FLT1 EPAS1 EPO CITED2 SLC2A1 PGK1 TCEB2 CREBBP TCEB1 SIRT1 HIF1AN VHL SERPINE1 EGLN1 EGLN3 ELK1 EGLN2 TWIST1 SLC11A2 POU5F1 MMP14 ADORA2A SP1 APEX1 EP300 BHLHE40 VEGFA EFNA1 EIF3E FXN ABCG2 ARNT ETS1 REGULATION OF ANDROGEN RECEPTOR ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF ANDROGEN RECEPTOR ACTIVITY Regulation of Androgen receptor activity GSK3B EGR1 GNB2L1 SIRT1 MAPK14 NR3C1 GATA2 NR2C1 EP300 HDAC7 NCOA1 NCOA2 JUN KAT2B POU2F1 AR KAT5 SRC MDM2 EHMT2 ZMIZ2 TRIM24 KAT7 SMARCC1 HDAC1 SENP1 PDE9A TMPRSS2 KLK3 KLK2 HOXB13 MAP2K6 RCHY1 FOXO1 NR2C2 RXRB RXRA SRY RXRG SPDEF SMARCE1 NR0B1 DNAJA1 APPBP2 CARM1 CREBBP MAPK8 MAP2K4 CEBPA HSP90AA1 REL SMARCA2 PKN1 PDGFR-ALPHA SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PDGFR-ALPHA SIGNALING PATHWAY PDGFR-alpha signaling pathway ITGAV PIK3CA SRF CAV1 PIK3R1 GRB2 RAPGEF1 SOS1 CRK PLCG1 JUN CAV3 FOS SHB SHC1 SHF CRKL PDGFRA ELK1 CSNK2A1 JAK1 SYNDECAN-3-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-3-MEDIATED SIGNALING EVENTS Syndecan-3-mediated signaling events FGF19 PSENEN NCAN SDC3 PTN PSEN1 FYN POMC MC4R APH1A CXCL8 NCSTN CTTN FGFR4 APH1B AGRP FGFR3 FGF23 EGFR SRC CASK SIGNALING MEDIATED BY P38-ALPHA AND P38-BETA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING MEDIATED BY P38-ALPHA AND P38-BETA Signaling mediated by p38-alpha and p38-beta DDIT3 PPARGC1A ATF1 GDI1 HSPB1 RPS6KA4 ELK4 RPS6KA5 MKNK1 MAPK11 EIF4EBP1 EIF4E MEF2A KRT8 PLA2G4A MITF USF1 KRT19 MAPKAPK3 MAPKAPK2 ATF2 MAPKAPK5 MAPK14 HBP1 ATF6 RAB5A NOS2 ESR1 TP53 SLC9A1 MEF2C PTGS2 JUN CREB1 CEBPB ALPHA4 BETA1 INTEGRIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA4 BETA1 INTEGRIN SIGNALING EVENTS Alpha4 beta1 integrin signaling events PTK2 ARF6 ABI1 CRK DOCK1 FN1 YWHAZ SPP1 ITGB1 PTK2B RAC1 IGSF8 CD81 THBS2 ITGA4 THBS1 ADAM28 MDK CD14 PRKACA BCAR1 AMICA1 GIT1 PRKACB JAM2 VCAM1 MYH2 PRKAR1B PTPRA PRKAR1A SRC PXN TLN1 WNT SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%WNT SIGNALING NETWORK Wnt signaling network LRP5 FZD10 LRP6 WIF1 RSPO1 WNT2 WNT3 CTHRC1 FZD1 FZD2 FZD5 WNT3A IGFBP4 FZD4 WNT7B FZD7 ATP6AP2 FZD6 WNT5A FZD9 KREMEN1 WNT7A FZD8 KREMEN2 DKK1 ROR2 WNT1 INTEGRIN-LINKED KINASE SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTEGRIN-LINKED KINASE SIGNALING Integrin-linked kinase signaling RUVBL1 NCK2 TNS1 GSK3B ILKAP PPP1R14A GIT2 PPP1R14B PPP1R14C CCND1 ACTN1 RHOG PARVB CKAP5 ZEB1 CTNNB1 PARVG NACA CDC37 ZYX SNAI1 TACC3 ELMO2 ILK MYL9 CDC42 LIMS2 LIMS1 AURKA AKT1 RAC1 PARP1 RICTOR JUN IQGAP1 HSP90AA1 PPP1R12A ARHGEF7 XPO1 CREB1 ARHGEF6 RUVBL2 DIAPH1 PXN IL5-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL5-MEDIATED SIGNALING EVENTS IL5-mediated signaling events CSF2RB PTPN11 PIK3CA PIK3R1 GRB2 STAT5B SDCBP JAK2 STAT5A PIM1 LYN IL5 CISH IL5RA AP-1 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AP-1 TRANSCRIPTION FACTOR NETWORK AP-1 transcription factor network CDK1 TGFB1 CXCL8 CCND1 EGR1 ATF2 CCL2 CDKN1B NR3C1 GATA2 MYC TH EP300 HIF1A IL6 IL10 CSF2 JUNB JUN NFATC3 NFATC2 NFATC1 FOS CRTC1 IL2 DMP1 CREB1 GJA1 FOSL1 MT2A IL4 NPPA ATF3 TIMP1 EDN1 DUSP1 HLA-A IFNG ELF1 CBFB DMTF1 NTS BAG1 PENK TCF7L2 BCL2L11 JUND AGT FOSL2 COPS5 FABP4 MAFG TRIP6 FOSB CTNNB1 ESR1 PLAU IL5 COL1A2 SP1 MAF TP53 PTEN CYR61 MMP9 ETS1 MMP1 MYB CDKN2A ACTA1 RXR AND RAR HETERODIMERIZATION WITH OTHER NUCLEAR RECEPTOR%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RXR AND RAR HETERODIMERIZATION WITH OTHER NUCLEAR RECEPTOR RXR and RAR heterodimerization with other nuclear receptor RXRB TGFB1 RXRA RXRG TNF VDR PPARG RARG RPS6KB1 THRB THRA FAM120B ABCA1 MED1 SREBF1 NR1H2 NR1H4 NR1H3 NCOA1 NR4A1 RARA RARB PPARA PPARD NCOR2 BCL2 N-CADHERIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%N-CADHERIN SIGNALING EVENTS N-cadherin signaling events CALM3 PTPN11 CALM1 PTPN1 CALM2 FER JUP CTTN PIK3R1 PLCG1 CTNNB1 LRP5 ROCK1 CDC42 MAPK8 RAC1 PIK3CA GSN RHOA PIP5K1C CTNND1 GRIA2 DAGLA CTNNA1 DCTN1 CNR1 GJA1 KIF5B CAMK2G AXIN1 CDH2 GAP43 MYL2 DAGLB MAPRE1 FGFR1 P63 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P63 TRANSCRIPTION FACTOR NETWORK p63 transcription factor network TP63 VALIDATED NUCLEAR ESTROGEN RECEPTOR ALPHA NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED NUCLEAR ESTROGEN RECEPTOR ALPHA NETWORK Validated nuclear estrogen receptor alpha network CCND1 STAT5A MYC EP300 NCOA1 NCOA2 COL18A1 CALCOCO1 CD82 MPG NCOR2 SRA1 PHB2 JUN DDX17 PDIA2 DSCAM NCOA3 HDAC4 AP1B1 NCOR1 DDX54 AXIN2 SAFB PRL LCOR PGR TRIM59 NCOA7 TFF1 CEBPB SET ANP32A HDAC1 PRDM15 ATP5J NEDD8 C3 MTA1 HSF2 NRIP1 APBB1 NDUFV3 XBP1 LMO4 KLRC3 ABCA3 GREB1 NR0B2 PCNA NR0B1 POU4F1 ESR2 POU4F2 BRCA1 SOD1 UBA3 EBAG9 UBE2M SMAD4 ESR1 MED1 CHUK CTSD SIGNALING EVENTS MEDIATED BY FOCAL ADHESION KINASE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY FOCAL ADHESION KINASE Signaling events mediated by focal adhesion kinase WASL NCK2 FYN YES1 GIT2 CCND1 ACTN1 PIK3R1 PLCG1 ELMO1 DOCK1 ITGB5 RAP1B BRAF ITGB1 PIK3CA MAPK9 JUN ITGA5 GRB7 RRAS SRC PXN RAP1A NCK1 ARHGAP35 PTK2 MAP2K1 RASA1 GRB2 RAPGEF1 SOS1 CRK RAF1 ROCK2 MAPK8 PTPN21 CAPN2 MAPK1 ITGAV SH3GL1 RAC1 ARHGEF11 ARHGEF28 ASAP1 BMX PAK1 ARHGAP26 KLF8 RHOA MAP2K4 BCAR1 ARHGEF7 ETS1 MAPK8IP3 ACTA1 TLN1 VCL ANGIOPOIETIN RECEPTOR TIE2-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ANGIOPOIETIN RECEPTOR TIE2-MEDIATED SIGNALING Angiopoietin receptor Tie2-mediated signaling AGTR1 DOK2 FYN PIK3R1 TNF RELA STAT5B FN1 CDKN1A MAPK14 PLD2 STAT5A ELK1 RPS6KB1 FES ITGB1 NFKB1 AKT1 PIK3CA ITGA5 GRB7 SHC1 PXN ELF1 NCK1 PTPN11 PTK2 FOXO1 RASA1 GRB2 CRK MAPK8 ANGPT1 NOS3 MAPK1 RAC1 MAPK3 TEK BMX PAK1 MMP2 FGF2 GRB14 F2 ELF2 PLG ANGPT4 ANGPT2 ETS1 DOWNSTREAM SIGNALING IN NAIVE CD8+ T CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DOWNSTREAM SIGNALING IN NAIVE CD8+ T CELLS Downstream signaling in naive CD8+ T cells CD3E IL2RG IFNA5 IFNA4 TNF IFNA7 IFNA6 IFNA1 EGR1 IFNA2 STAT4 IFNA8 TNFRSF4 B2M IFNAR2 EOMES IFNA13 BRAF ELK1 IFNA14 IFNA16 TNFRSF18 PTPN7 IFNA17 CD8B CD8A PRKCQ IFNA10 IFNAR1 IFNA21 EGR4 TNFRSF9 GZMB FASLG PRF1 CD3G CD3D JUNB MAPK9 JUN NFATC3 NFATC2 NRAS NFATC1 FOS CD247 IL2 FOSL1 PRKCB PRKCE HRAS HLA-A IFNG IL2RA KRAS CALM3 CALM1 CALM2 PRKCA MAP2K1 MAP2K2 RAF1 MAPK8 MAPK1 MAPK3 IL2RB ALPHA6 BETA4 INTEGRIN-LIGAND INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA6 BETA4 INTEGRIN-LIGAND INTERACTIONS Alpha6 beta4 integrin-ligand interactions ITGB4 LAMC2 ITGA6 LAMC1 LAMB3 LAMA2 LAMA1 LAMB2 LAMA5 LAMA3 LAMB1 FANCONI ANEMIA PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FANCONI ANEMIA PATHWAY Fanconi anemia pathway BLM WDR48 FAAP24 BRCA1 BRCA2 BRIP1 CHEK1 TOPBP1 USP1 NBN ATRIP FAAP100 RFC5 FANCL FANCI RFC3 FANCA RFC4 MRE11A FANCM FANCC RMI1 FANCE RFC2 FANCG TOP3A FANCF XRCC3 RAD50 H2AFX RPA1 RPA2 FANCD2 HUS1 FANCB ATM PALB2 HES1 APITD1 ATR UBE2T RAD17 RAD1 FAN1 RAD9A BTRC FBXW11 VALIDATED TRANSCRIPTIONAL TARGETS OF DELTANP63 ISOFORMS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TRANSCRIPTIONAL TARGETS OF DELTANP63 ISOFORMS Validated transcriptional targets of deltaNp63 isoforms TP63 ADA FOSL2 GSK3B YAP1 TOP2A STXBP4 DLX5 RRAD DLX6 SFN SEC14L2 CCNB2 T BRCA2 PERP BDKRB2 HELLS GNB2L1 TCF7L1 HBP1 NOTCH1 GPX2 FBXW7 VDR IGFBP3 ADRM1 ITGA3 PPP2R5A WWP1 MRE11A NRG1 KRT5 POU2F2 IL1A ITCH AXL FASN KRT14 RAB38 ATM HES1 CEBPD RUNX1 CDKN2A MDM2 COL5A1 CASPASE CASCADE IN APOPTOSIS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CASPASE CASCADE IN APOPTOSIS Caspase cascade in apoptosis TNF GZMB PRF1 PARP1 CASP9 APP NUMA1 CASP8 LMNB1 CASP10 PIDD1 CASP3 CASP7 RIPK1 CFL2 ARHGDIB CASP4 BID CASP1 CASP2 PTK2 SPTAN1 DFFB DFFA APAF1 GAS2 TOP1 SATB1 BIRC2 DIABLO XIAP LMNA TFAP2A KRT18 CASP6 SREBF1 MAP3K1 GSN TRADD BIRC3 CRADD VIM TRAF2 TNFRSF1A BCL2 LIMK1 MADD CYCS BAX ACTA1 IL8-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL8-MEDIATED SIGNALING EVENTS IL8-mediated signaling events CXCL8 AMB2 INTEGRIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AMB2 INTEGRIN SIGNALING amb2 Integrin signaling THY1 TNF ROCK1 RAP1B SELP PLAU SELPLG HCK ITGAM LRP1 PLAT NFKB1 ITGB2 HMGB1 MST1R IL6 AGER CTGF ICAM1 APOB JAM3 MMP2 PLAUR MMP9 LPA RHOA JAM2 PLG MYH2 RAP1A TLN1 REGULATION OF RAC1 ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RAC1 ACTIVITY Regulation of RAC1 activity CHN1 DEF6 VAV1 TRIO BCR TIAM2 ARHGEF2 DOCK2 TIAM1 ABI1 SOS1 ELMO1 DOCK1 KALRN RACGAP1 VAV2 RAC1 DOCK6 VAV3 ARHGEF25 NGEF ARHGAP1 ARHGAP17 RASGRF2 RASGRF1 RALBP1 MCF2 SPATA13 ARHGEF7 ARHGEF6 ARHGAP9 RAP1GDS1 EPS8 PREX2 ARHGDIA ABR PREX1 CHN2 FC-EPSILON RECEPTOR I SIGNALING IN MAST CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FC-EPSILON RECEPTOR I SIGNALING IN MAST CELLS Fc-epsilon receptor I signaling in mast cells VAV1 IGHE FYN PIK3R1 CBL PLA2G4A PLCG1 RELA ITK WIPF1 CBLB SPHK1 PLD2 FCER1A FCER1G LAT2 PPAP2A LYN HCLS1 LCP2 MS4A2 S1PR1 PLA2G1B PTPN13 NFKB1 FCGR2B AKT1 PIK3CA JUN NFATC2 FOS SHC1 PRKCB PXN IKBKB DUSP1 HRAS IKBKG PTPN11 MAP2K7 PAK2 FER PTK2 DOK1 MAP2K1 MAP2K2 RASA1 BTK LAT GAB2 GRB2 SOS1 RAF1 MAPK8 MAPK1 MAPK3 MAP3K1 SYK CHUK MAP2K4 S1P3 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P3 PATHWAY S1P3 pathway PDGFRB FLT1 GNAI3 PDGFB GNAI1 JAK2 GNA14 GNA15 GNAQ GNA11 S1PR3 MAPK1 AKT1 RAC1 VEGFA CXCR4 MAPK3 RHOA GNAO1 GNAZ AKT3 GNA12 GNAI2 GNA13 SRC ARF6 DOWNSTREAM PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF6 DOWNSTREAM PATHWAY Arf6 downstream pathway RAC1 MAPK3 ARF1 RAB11A PLAUR RAB11FIP3 ARF6 TIAM1 RHOA PLD1 PLD2 KALRN NME1 PIP5K1A MAPK1 A4B7 INTEGRIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%A4B7 INTEGRIN SIGNALING a4b7 Integrin signaling VCAM1 PTK2 ITGB7 ITGA4 PXN MADCAM1 RHOA ITGB1 NEUROTROPHIC FACTOR-MEDIATED TRK RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NEUROTROPHIC FACTOR-MEDIATED TRK RECEPTOR SIGNALING Neurotrophic factor-mediated Trk receptor signaling CCND1 PIK3R1 RHOG PLCG1 ELMO1 DOCK1 RAP1B STAT3 DNM1 PIK3CA RASGRF1 PRKCZ NRAS SHC1 RAP1A PRKCI HRAS DYNLT1 MATK SQSTM1 KRAS GAB1 FAIM SHC2 PTPN11 SHC3 FRS2 RGS19 MAGED1 NEDD4L ABL1 MAP2K1 NGFR RIT1 TIAM1 EHD4 RASA1 RIT2 GAB2 GIPC1 NGF DNAJA3 GRB2 FRS3 RAPGEF1 SOS1 CRK NTF4 NTF3 CRKL CDC42 NTRK1 NTRK2 MAPK1 BDNF NTRK3 RAC1 MAPK3 RHOA MCF2L CLASS I PI3K SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CLASS I PI3K SIGNALING EVENTS Class I PI3K signaling events FOXO3 FYN YES1 ARF6 BTK LAT PIK3R1 LCK BLK PLCG1 SGK1 ITK PDPK1 PIK3CG PIK3R6 INPPL1 LYN DAPP1 CYTH3 CYTH2 FGR BLNK HCK PLCG2 CYTH1 RAC1 PLEKHA1 ARAP3 ADAP1 ZAP70 PIK3CA ARF5 ARF1 SYK PTEN RHOA HSP90AA1 NRAS SRC PIK3CB RAP1A HRAS KRAS GMCSF-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GMCSF-MEDIATED SIGNALING EVENTS GMCSF-mediated signaling events PTPN11 MAP2K1 MAP2K2 GAB2 PIK3R1 GRB2 SOS1 RAF1 STAT5B CCL2 JAK2 STAT5A YWHAZ PIM1 LYN STAT1 STAT3 CISH MAPK1 CSF2RB MAPK3 PIK3CA SYK CSF2 CSF2RA PRKACG OSM PRKACA IRF8 PRKACB NRAS FOS SHC1 IKBKB HRAS KRAS ERBB4 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB4 SIGNALING EVENTS ErbB4 signaling events WWOX NRG2 TAB2 GRIN2B CBFA2T3 EREG BTC ADAM17 FYN NRG3 DLG4 YAP1 NRG4 NEDD4 HBEGF PIK3R1 GRB2 STAT5B JAK2 STAT5A WWP1 NRG1 MAPK1 ITCH MAPK3 PIK3CA NCOR1 SHC1 PRL MDM2 PIK3CB ERBB4 ERBB2 PRLR LRIG1 SIGNALING MEDIATED BY P38-GAMMA AND P38-DELTA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING MEDIATED BY P38-GAMMA AND P38-DELTA Signaling mediated by p38-gamma and p38-delta MAP2K3 STMN1 EEF2K MAPT SNTA1 MAPK13 MAP2K6 MAPK12 CCND1 PKN1 STABILIZATION AND EXPANSION OF THE E-CADHERIN ADHERENS JUNCTION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%STABILIZATION AND EXPANSION OF THE E-CADHERIN ADHERENS JUNCTION Stabilization and expansion of the E-cadherin adherens junction EXOC4 CYFIP2 NCKAP1 IGF1R EXOC3 ENAH ARF6 ACTN1 ABI1 MET CTNNB1 ROCK1 MLLT4 ZYX EGFR EGF EFNA1 AQP5 LPP AQP3 LIMA1 MYO6 MGAT3 STX4 EPHA2 VASP RHOA PLEKHA7 CAMSAP3 KIFC3 PIP5K1C PVRL2 GIT1 CTNND1 CDH1 CTNNA1 HGF DIAPH1 MYL2 NCK1 VCL SIGNALING EVENTS MEDIATED BY VEGFR1 AND VEGFR2%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY VEGFR1 AND VEGFR2 Signaling events mediated by VEGFR1 and VEGFR2 NCK2 FYN CAV1 NEDD4 PIK3R1 CBL FLT1 PLCG1 MAPKAPK2 ROCK1 PDPK1 MAPK14 PRKCD BRAF FES PTPN6 AKT1 PIK3CA ARF1 PRKACA HSP90AB1 SRC PTPRJ PRKCB PXN CDH5 MYOF GRB10 HGS SH2D2A CAMKK2 NCK1 AKAP1 GAB1 VTN CALM3 PTPN11 CALM1 PTPN2 CALM2 KDR PRKCA PAK2 MAP2K6 PTK2 MAP2K1 MAP2K2 MAPK11 GRB2 RAF1 CTNNB1 SHB ITGB3 CDC42 PTK2B NOS3 MAPK1 ITGAV VEGFA MAPK3 RHOA MAP2K3 HSP90AA1 IQGAP1 FBXW11 CTNNA1 DNM2 VCL VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL ACTIVATION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL ACTIVATION Validated targets of C-MYC transcriptional activation DDX18 ACTL6A CAD NME2 RUVBL1 SUPT7L SUPT3H CDC25A BCAT1 GAPDH PTMA SHMT1 RPL11 EIF4E TAF9 ODC1 IREB2 CDCA7 AK6 HSPD1 SLC2A1 MTDH PRDX3 LDHA HMGA1 MYCT1 SNAI1 PDCD10 PMAIP1 E2F3 TAF12 HSPA4 TAF10 HUWE1 KIR3DL1 MINA MYC EIF2S1 EP300 LIN28B GPAM POLR3D ID2 NDUFAF2 TAF4B SERPINI1 PFKM EIF4G1 KAT2A KAT5 RUVBL2 FOSL1 MAX MTA1 CREBBP NBN SMAD4 SMAD3 PIM1 CDK4 NPM1 TP53 CCNB1 MMP9 NCL BIRC5 TERT HSP90AA1 EIF4A1 TFRC BAX TRRAP ENO1 BMI1 CCND2 PEG10 NME1 UBTF RCC1 TK1 REGULATION OF P38-ALPHA AND P38-BETA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF P38-ALPHA AND P38-BETA Regulation of p38-alpha and p38-beta RIPK1 RALA RALB TAB1 PAK2 MAP2K6 FYN YES1 MAPK11 LCK BLK MAPK14 CDC42 LYN FGR HCK RAC1 PAK1 MAP2K4 DUSP16 PAK3 MAP2K3 MAP3K3 TRAF6 CCM2 MAP3K12 DUSP10 SRC DUSP1 DUSP8 SIGNALING EVENTS MEDIATED BY STEM CELL FACTOR RECEPTOR (C-KIT)%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY STEM CELL FACTOR RECEPTOR (C-KIT) Signaling events mediated by Stem cell factor receptor (c-Kit) VAV1 GSK3B PIK3R1 CBL SOCS1 MITF EPO BAD PDPK1 JAK2 STAT5A LYN RPS6KB1 STAT1 STAT3 PTPN6 AKT1 PIK3CA SHC1 GRB10 HRAS MATK GAB1 PTPRO PTPN11 PIK3C2B SPRED2 SPRED1 FER GRAP2 FOXO3 MAP4K1 DOK1 MAP2K1 STAP1 MAP2K2 SH2B3 EPOR TEC SNAI2 GRB2 SOS1 RAF1 CREBBP CRKL MAPK8 MAPK3 KIT PTEN BCL2 KITLG GLYPICAN 3 NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN 3 NETWORK Glypican 3 network BMP4 FGF7 GPC3 PTCH1 FURIN SHH MAPK8 MAPK9 ALPHA9 BETA1 INTEGRIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA9 BETA1 INTEGRIN SIGNALING EVENTS Alpha9 beta1 integrin signaling events FN1 NOS2 SPP1 ITGB1 FIGF TNC RAC1 VEGFA F13A1 SAT1 TGM2 KCNJ15 VEGFC CSF2 ADAM2 ADAM15 ADAM12 CSF2RA ADAM8 PAOX BCAR1 VCAM1 ITGA9 SRC PXN DNA-PK PATHWAY IN NONHOMOLOGOUS END JOINING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DNA-PK PATHWAY IN NONHOMOLOGOUS END JOINING DNA-PK pathway in nonhomologous end joining NHEJ1 PRKDC XRCC6 DCLRE1C XRCC4 POLM XRCC5 PNKP LIG4 DNTT APTX APLF POLL SIGNALING EVENTS MEDIATED BY HEPATOCYTE GROWTH FACTOR RECEPTOR (C-MET)%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HEPATOCYTE GROWTH FACTOR RECEPTOR (C-MET) Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) F2RL2 WASL NCK2 ARF6 EIF4EBP1 EIF4E PIK3R1 CBL MET SH3KBP1 PLCG1 RPTOR DEPTOR AKT1S1 EGR1 NUMB ARHGEF4 BAD PDPK1 RIN2 SNAI1 KPNB1 EPS15 MTOR RAB5A PAK4 RAP1B RANBP9 RANBP10 MUC20 AKT1 PIK3CA AKT2 MLST8 PRKCZ JUN SHC1 SRC PTPRJ PXN RAP1A PRKCI HGS HRAS NCK1 GAB1 PTPN11 PTPN2 PTPN1 PAK2 PTK2 MAP2K1 MAP2K2 GAB2 GRB2 RAPGEF1 SOS1 CRK RAF1 CTNNB1 CRKL CDC42 INPPL1 MAPK8 MAPK1 RAC1 MAPK3 MAP3K1 PAK1 RHOA PARD6A MAP2K4 BCAR1 SH3GL2 CDH1 APC CTNNA1 ETS1 HGF EGF RECEPTOR (ERBB1) SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EGF RECEPTOR (ERBB1) SIGNALING PATHWAY EGF receptor (ErbB1) signaling pathway GAB1 PTPN11 PTPN1 WASL NCK2 PTK2 RASA1 PIK3R1 GRB2 SOS1 PLCG1 GNAI3 GNAI1 EGFR STAT1 STAT3 EGF PTPN6 MAPK1 MAPK3 PIK3CA PAK1 GSN PIP5K1C NRAS SHC1 SRC PIK3CB HRAS TLN1 NCK1 KRAS PAR1-MEDIATED THROMBIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PAR1-MEDIATED THROMBIN SIGNALING EVENTS PAR1-mediated thrombin signaling events F2RL2 PRKCA PIK3R1 GNAI3 ROCK1 ZYX GNAI1 ROCK2 PRKCD GNA14 GNA15 GNAQ GNA11 NOS3 DNM1 PLCB2 PIK3CA VASP ARRB1 RHOA AKAP13 SNX1 SNX2 GNAO1 GNAZ GNG2 ADRBK2 GNA12 PRKCG F2 GNAI2 TRPC6 GNA13 F2R PLCB3 GNB1 ARHGEF1 PLCB1 PRKCB MYL2 ARHGDIA DNM2 PKN1 SYNDECAN-4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-4-MEDIATED SIGNALING EVENTS Syndecan-4-mediated signaling events CXCL12 PRKCA PTK2 GIPC1 TNFRSF13B ACTN1 LAMA1 LAMA3 FN1 PRKCD ITGB1 TNC RAC1 FZD7 CXCR4 MMP9 ADAM12 THBS1 RHOA MDK FGF2 F2 PLG SDCBP ITGA5 CCL5 SDC4 TFPI DNM2 FGF6 FGFR1 NUDT16L1 P53 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P53 PATHWAY p53 pathway GSK3B RPL11 PRMT5 MAPK14 PRKCD HUWE1 EP300 AKT1 YY1 MAPK9 KAT2B KAT5 MDM2 CCNA2 NEDD8 SKP2 CSNK1G3 RCHY1 ABL1 USP7 CSNK1A1 CSNK1D CSNK1E CSNK1G2 CSNK1G1 CHEK1 CREBBP TRIM28 RPL5 DYRK2 SETD8 MAPK8 CSE1L SETD7 UBE2D1 TP53AIP1 RASSF1 PPP2R4 CDK2 PPP1R13L PPP2CA CHEK2 KAT8 DAXX RPL23 ATM FBXO11 TP53 PPM1D ATR SMYD2 E4F1 RFWD2 TTC5 CCNG1 PIN1 MDM4 CDKN2A HIPK2 E-CADHERIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E-CADHERIN SIGNALING EVENTS E-cadherin signaling events CTNNB1 CDH1 JUP CALCINEURIN-REGULATED NFAT-DEPENDENT TRANSCRIPTION IN LYMPHOCYTES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CALCINEURIN-REGULATED NFAT-DEPENDENT TRANSCRIPTION IN LYMPHOCYTES Calcineurin-regulated NFAT-dependent transcription in lymphocytes RNF128 CALM3 CALM1 PTPN1 CALM2 GATA3 IRF4 CXCL8 TNF EGR1 EGR2 CBLB PPARG IL5 CDK4 ITCH PRKCQ MAF EGR4 CSF2 FASLG PTGS2 JUNB TBX21 BATF3 E2F1 JUN POU2F1 NFATC3 NFATC2 NFATC1 FOS IL2 DGKA FOSL1 SLC3A2 IL4 PTPRK IKZF1 IL3 CTLA4 CD40LG GBP3 IFNG EGR3 CASP3 FOXP3 IL2RA S1P2 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P2 PATHWAY S1P2 pathway RAC1 MAPK3 PAK1 RHOA GNAO1 GNAZ GNA12 JUN GNAI2 GNAI3 GNA13 FOS MAPK14 GNAI1 IRS1 GNA14 GNA15 ELK1 CDH5 MAPK8 GNAQ GNA11 MAPK1 S1PR2 PLK3 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLK3 SIGNALING EVENTS PLK3 signaling events PLK3 CCNE1 CHEK2 TP53 CDC25C NONGENOTROPIC ANDROGEN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NONGENOTROPIC ANDROGEN SIGNALING Nongenotropic Androgen signaling PELP1 PTK2 GNRH1 SHBG MAP2K1 MAP2K2 PIK3R1 PLCG1 RAF1 GNAI3 GNAI1 CDC42 PLCG2 MAPK1 AKT1 RAC1 PLCB2 MAPK3 PIK3CA GNAO1 GNAZ GNG2 GNAI2 AR PLCB3 GNB1 FOS PLCB1 CREB1 SRC HRAS VALIDATED TRANSCRIPTIONAL TARGETS OF AP1 FAMILY MEMBERS FRA1 AND FRA2%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TRANSCRIPTIONAL TARGETS OF AP1 FAMILY MEMBERS FRA1 AND FRA2 Validated transcriptional targets of AP1 family members Fra1 and Fra2 JUND FOSL2 CXCL8 CCND1 LAMA3 TXLNG THBD HMOX1 LIF CCL2 USF2 DCN MGP IVL ATF4 PLAU COL1A2 NOS3 SP1 ITGB4 EP300 IL6 BGLAP MMP2 PLAUR MMP9 JUNB JUN NFATC3 NFATC2 NFATC1 MMP1 GJA1 FOSL1 CDKN2A CCNA2 DMTF1 ATM PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATM PATHWAY ATM pathway CTBP1 BID ABL1 CDC25A YWHAB BLM BRCA1 TRIM28 NBN MRE11A TOP3A RAD50 H2AFX MDC1 CHEK2 RNF8 FANCD2 SMC3 UIMC1 ATM RBBP8 TP53BP1 SMC1A TERF2 FAM175A RAD17 RFWD2 UBE2N RAD9A DCLRE1C KAT5 CDC25C XRCC4 MDM2 HIV-1 NEF: NEGATIVE EFFECTOR OF FAS AND TNF-ALPHA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HIV-1 NEF: NEGATIVE EFFECTOR OF FAS AND TNF-ALPHA HIV-1 Nef: Negative effector of Fas and TNF-alpha CASP7 RIPK1 FADD BID MAP2K7 CASP2 CFLAR APAF1 FAS TNF RELA CASP6 MAPK8 NFKB1 NFKBIA DAXX TRADD CHUK FASLG BAG4 MAP3K14 BIRC3 CASP9 TRAF1 CRADD MAP3K5 TRAF2 TNFRSF1A BCL2 CD247 CYCS CASP8 CASP3 ENDOGENOUS TLR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ENDOGENOUS TLR SIGNALING Endogenous TLR signaling IRAK4 HMGB1 TICAM1 IKBKG TIRAP TLR1 VCAN IRAK1 IRAK2 CHUK TLR6 SFTPA1 S100A9 RHOA TLR4 TLR3 MYD88 CD14 S100A8 TLR2 HSPD1 IKBKB BGN LY96 IL27-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL27-MEDIATED SIGNALING EVENTS IL27-mediated signaling events GATA3 TGFB1 TNF IL6ST STAT4 EBI3 IL12B IL27 JAK2 IL27RA IL12RB1 IL12A STAT5A IL12RB2 STAT2 STAT1 STAT3 IL18 TYK2 IL6 IL1B IL17A TBX21 IL2 IFNG JAK1 P75(NTR)-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P75(NTR)-MEDIATED SIGNALING p75(NTR)-mediated signaling YWHAE ADAM17 PIK3R1 BAD AKT1 PIK3CA CASP9 MAPK9 PRKACB PRKCZ TRAF6 SHC1 APP IKBKB ARHGDIA PRKCI CASP3 SQSTM1 IKBKG MAGED1 BCL2L11 IRAK1 NGFR MAPK10 APAF1 NGF MYD88 BIRC2 DIABLO XIAP FURIN CASP6 NTF4 NTF3 MAPK8 NTRK1 BDNF RAC1 PSENEN TP53 CHUK PSEN1 RHOA APH1A BIRC3 NCSTN PRDM4 APH1B SMPD2 RIPK2 MMP3 OMG E2F1 RHOC RHOB PLG MAG NGFRAP1 RTN4R MMP7 MAGEH1 CYCS ZNF274 BEX1 RTN4 NDNL2 NDN SORT1 CANONICAL WNT SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CANONICAL WNT SIGNALING PATHWAY Canonical Wnt signaling pathway RANBP3 KLHL12 NKD2 GSK3B DVL1 DVL2 DVL3 GSK3A CAV1 PI4K2A PIP5K1B CTNNB1 CSNK1G1 CUL3 LRP6 APC AXIN1 PPP2R5A FZD5 WNT3A FGF SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FGF SIGNALING PATHWAY FGF signaling pathway GAB1 FGF19 PTPN11 FRS2 CAMK2A SPRY2 CTTN FGFR4 PIK3R1 CBL GRB2 SOS1 FGFR3 PLCG1 SDC2 KLB STAT5B FGF1 RPS6KA1 NCAM1 PDPK1 IL17RD SSH1 PAK4 FGFR2 PLAU STAT1 SPP1 PTK2B MAPK1 AKT1 MAPK3 BGLAP PIK3CA PLAUR MMP9 RUNX2 CTNND1 JUN CDH1 FGF23 FOS SHC1 SRC CDH2 FGFR1 COREGULATION OF ANDROGEN RECEPTOR ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%COREGULATION OF ANDROGEN RECEPTOR ACTIVITY Coregulation of Androgen receptor activity PELP1 CCND1 KDM1A RANBP9 AKT1 TGIF1 PIAS4 PIAS3 NCOA2 AR HIP1 UBE2I TGFB1I1 FHL2 UBE3A RPS6KA3 CCND3 ZMIZ1 CASP8 APPL1 PIAS1 NKX3-1 NCOA6 NCOA4 LATS2 CTDSP1 TMPRSS2 MAK KLK3 CTDSP2 KLK2 ZNF318 SNURF NRIP1 FKBP4 KDM3A TMF1 PRDX1 HNRNPA1 PATZ1 SVIL KDM4C PRKDC PA2G4 CTNNB1 TCF4 BRCA1 CARM1 CMTM2 UBA3 XRCC6 XRCC5 PTK2B MED1 VAV3 GSN SRF PAWR CDKN2A CDK6 ALK2 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALK2 SIGNALING EVENTS ALK2 signaling events BMPR2 TLX2 SMAD4 AMHR2 ACVR1 AMH FKBP1A SMAD1 BMP7 SMAD9 SMAD5 E-CADHERIN SIGNALING IN KERATINOCYTES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E-CADHERIN SIGNALING IN KERATINOCYTES E-cadherin signaling in keratinocytes AKT1 RAC1 PIK3CA JUP FYN VASP RHOA PIK3R1 AKT2 CTNND1 PLCG1 CTNNB1 CDH1 ZYX CTNNA1 EGFR SRC CASR FMN1 PIP5K1A AJUBA IL6-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL6-MEDIATED SIGNALING EVENTS IL6-mediated signaling events GAB1 PTPN11 VAV1 IL6R MAP2K6 FOXO1 MAPK11 LMO4 GAB2 PIK3R1 GRB2 SOS1 MITF IL6ST SOCS3 MAPK14 JAK2 PRKCD STAT1 STAT3 HCK BCL2L1 MYC TYK2 AKT1 RAC1 IL6 PIK3CA CRP HSP90B1 PIAS3 TNFSF11 LBP A2M MCL1 MAP2K4 FGG PTPRE JUNB CEBPD JUN IRF1 FOS TIMP1 CEBPB PIAS1 JAK1 EPHRINA-EPHA PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRINA-EPHA PATHWAY EphrinA-EPHA pathway EFNA5 EPHA3 EPHA2 EPHA5 EPHA4 EPHA7 EPHA6 EPHA8 ATR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATR SIGNALING PATHWAY ATR signaling pathway CDC25A YWHAB BRCA2 CHEK1 TOPBP1 NBN ATRIP RFC5 YWHAZ RFC3 RFC4 RFC2 CDK2 PPP2CA RAD51 RPA1 RPA2 FANCD2 HUS1 ATR PPP2R1A RAD17 CLSPN RAD1 RAD9A BTRC FBXW11 SMARCAL1 PLK1 MCM7 CDC25C CEP164 TIPIN MDM2 CDC6 PPP2R2B TIMELESS MCM2 CCNA2 IGF1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IGF1 PATHWAY IGF1 pathway PTPN11 PTPN1 IGF1R NCK2 PTK2 YWHAE PIK3R1 GRB2 SOS1 CRK RAF1 BAD GNB2L1 PDPK1 PRKCD YWHAZ CRKL RPS6KB1 AKT1 PIK3CA BCAR1 PRKCZ IRS1 SHC1 PXN IRS2 GRB10 HRAS PRKD1 DEGRADATION OF BETA CATENIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DEGRADATION OF BETA CATENIN Degradation of beta catenin CUL1 SKP1 GSK3B DVL1 DVL2 CSNK1A1 DVL3 GSK3A CSNK1D CSNK1E BTRC CTNNB1 LRP6 APC AXIN2 AXIN1 FZD5 WNT3A CELLULAR ROLES OF ANTHRAX TOXIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CELLULAR ROLES OF ANTHRAX TOXIN Cellular roles of Anthrax toxin CALM3 CALM1 CALM2 MAPK3 CASP1 MAP2K7 MAP2K6 IL1B MAP2K1 MAP2K2 DEFA1 ANTXR2 ANTXR1 MAP2K4 NLRP1 DEFA1B TNF MAP2K3 VCAM1 PGR IL18 MAPK1 VISUAL SIGNAL TRANSDUCTION: RODS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VISUAL SIGNAL TRANSDUCTION: RODS Visual signal transduction: Rods GUCY2D GUCA1B GUCA1A GUCA1C GUCY2F RPE65 GRK1 GNB1 RDH12 RGS9BP SLC24A1 PDE6G GNGT1 RHO SAG RDH5 CNGA1 LRAT PDE6B GNB5 PDE6A GNAT1 RGS9 FOXM1 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXM1 TRANSCRIPTION FACTOR NETWORK FOXM1 transcription factor network CDK1 SKP2 AURKB MAP2K1 CCND1 CCNB2 BRCA2 RB1 CREBBP CENPA ESR1 CDK4 MYC SP1 EP300 CDK2 CHEK2 CCNE1 CCNB1 MMP2 GSK3A BIRC5 LAMA4 ONECUT1 TGFA GAS1 FOXM1 CENPB CKS1B ETV5 NEK2 NFATC3 XRCC1 CENPF FOS HIST1H2BA PLK1 HSPA1B HSPA1A CDKN2A CDC25B CCNA2 IL8- AND CXCR1-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL8- AND CXCR1-MEDIATED SIGNALING EVENTS IL8- and CXCR1-mediated signaling events PRKCA ARRB2 CXCL8 CBL PLD1 PDPK1 PIK3CG PIK3R6 RAB5A GNA14 GNA15 LYN FGR HCK AKT1 DNM1 PLCB2 ARRB1 ADRBK1 GNG2 PRKCG GNAI2 PLCB3 GNB1 PLCB1 CXCR1 PRKCB PRKCE PDGFR-BETA SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PDGFR-BETA SIGNALING PATHWAY PDGFR-beta signaling pathway NCK2 YWHAE YWHAB YWHAQ PIK3R1 SFN PLCG1 YWHAG YWHAH PRKCD JAK2 SPHK1 STAT5A YWHAZ RAP1B BRAF ELK1 STAT1 STAT3 S1PR1 PIK3CA MAPK9 JUN NRAS FOS PRKCE PIK3CB KRAS CYFIP2 NCKAP1 WASF2 MAP2K7 JUND USP6NL ABL1 SLA ACTN4 MAPK10 SLC9A3R2 SLC9A3R1 RAB4A CTTN DOCK4 ABI1 MYOCD RAPGEF1 ARAP1 ACTA2 TAGLN SIPA1 ITGB3 MAPK8 MAPK1 ITGAV VAV2 RAC1 PPP2CA MAPK3 PAK1 PPP2R1A RHOA MAP2K4 KSR1 BCAR1 EIF2AK2 WASL FYN YES1 CBL PLA2G4A BLK STAT5B PIK3CG PIK3R6 RAB5A LYN FGR HCK MYC SHC1 SRC ARPC1B PTPRJ RPS6KA3 BRK1 RAP1A ARHGDIA GRB10 HRAS ACTR3 ACTR2 NCK1 GAB1 CSK PTPN11 PTPN2 ARHGAP35 PTPN1 PRKCA ARPC4 PDGFRB DOK1 ARPC5 MAP2K1 BAIAP2 MAP2K2 ARPC2 ARPC3 RASA1 GRB2 SOS1 LCK CRK RAF1 PDGFB MLLT4 PAG1 LRP1 SRF PTEN PIN1 IQGAP1 EPS8 PPP2R2B DNM2 INSULIN-MEDIATED GLUCOSE TRANSPORT%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INSULIN-MEDIATED GLUCOSE TRANSPORT Insulin-mediated glucose transport INS CALM3 CALM1 CALM2 INSR YWHAE GSK3B YWHAB STXBP4 YWHAQ SFN YWHAG YWHAH YWHAZ ASIP PPP1R3A GYS1 LNPEP TRIP10 PPP1CC VAMP2 RHOQ AKT1 STX4 AKT2 PRKCZ SLC2A4 TBC1D4 PRKCI BETA2 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA2 INTEGRIN CELL SURFACE INTERACTIONS Beta2 integrin cell surface interactions C3 FCGR2A THY1 KNG1 PLAU ITGAM PLAT ITGB2 ITGAL ICAM1 ITGAX JAM3 CYR61 PLAUR SPON2 ICAM2 FGG ITGAD ICAM3 ICAM4 F11R FGB FGA VCAM1 F10 GP1BA PROC TGFBI CD40LG ALK1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALK1 PATHWAY ALK1 pathway ACVRL1 ACVR1 FKBP1A NECTIN ADHESION PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NECTIN ADHESION PATHWAY Nectin adhesion pathway PTK2 PDGFRB PIK3R1 RAPGEF1 CRK CTNNB1 PDGFB MLLT4 ITGB3 CDC42 RAP1B ITGAV VAV2 RAC1 PIK3CA PIP5K1C PVRL2 F11R FARP2 IQGAP1 CDH1 CTNNA1 SRC PTPRM RAP1A PVR CLDN1 PVRL3 TLN1 PVRL1 BCR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BCR SIGNALING PATHWAY BCR signaling pathway PIK3R1 PPP3CB PPP3CC RELA CARD11 BCL2A1 BCL10 MALT1 PDPK1 CD79B MAPK14 CD79A CD19 SH3BP5 CD72 ELK1 LYN IBTK PTPRC CSNK2A1 CD22 PTPN6 NFKBIB POU2F2 NFKB1 FCGR2B AKT1 NFKBIA PIK3CA JUN TRAF6 NFATC1 FOS SHC1 IKBKB HRAS CALM3 IKBKG CSK CALM1 CALM2 MAP4K1 DOK1 MAP2K1 RASA1 BTK GRB2 SOS1 RAF1 PPP3CA PAG1 MAPK8 DAPP1 MAP3K7 BLNK PLCG2 MAPK1 VAV2 RAC1 MAPK3 MAP3K1 SYK PTEN CHUK ETS1 CAMK2G REGULATION OF RHOA ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RHOA ACTIVITY Regulation of RhoA activity NET1 DEF6 OBSCN ARHGAP35 ARHGDIB VAV1 DLC1 TRIO BCR ARHGEF3 ARHGEF5 ARHGEF2 ARAP1 CDKN1B ARHGEF15 VAV2 ARHGEF11 ARHGEF28 ARAP3 VAV3 ARHGEF25 NGEF RHOA AKAP13 ECT2 MCF2L MCF2 ARHGAP8 ARHGDIG ARHGEF10L ARHGAP6 ARHGEF1 ARHGAP4 OPHN1 SRGAP1 ARHGAP9 ARHGEF10 FARP1 ARHGAP5 ARHGEF12 ARHGDIA ARHGEF17 ABR PLEKHG6 ARHGEF18 MYO9B EFFECTS OF BOTULINUM TOXIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EFFECTS OF BOTULINUM TOXIN Effects of Botulinum toxin SNAP25 SYT1 STXBP1 RAB3GAP2 STX1A CHRNA1 UNC13B VAMP2 RIMS1 NOTCH SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NOTCH SIGNALING PATHWAY Notch signaling pathway CUL1 SKP1 CCND1 CBL NUMB CDKN1A NOTCH1 MAML2 FBXW7 EPS15 KDM1A MAML1 RBPJ MYC EP300 ITCH DNM1 YY1 RBBP8 RAB11A SPEN NCOR2 NCOR1 IL4 HDAC1 CTBP1 GATA3 SKP2 FURIN PTCRA PSENEN ADAM12 DNER APH1A ADAM10 NCSTN NOTCH2 APH1B BTRC NOTCH3 MYCBP NOTCH4 DTX1 DLL1 DLL3 DLL4 MARK2 JAG2 JAG1 CNTN6 DLK1 ENO1 MIB1 MFAP5 NEURL1 MFAP2 CNTN1 LNX1 GLYPICAN 2 NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN 2 NETWORK Glypican 2 network GPC2 MDK IL2 SIGNALING EVENTS MEDIATED BY STAT5%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL2 SIGNALING EVENTS MEDIATED BY STAT5 IL2 signaling events mediated by STAT5 PTPN11 LTA GAB2 PIK3R1 GRB2 IL2RG SOS1 LCK STAT5B STAT5A BCL2L1 MYC SP1 IL2RB PIK3CA FASLG PRF1 BCL2 IL2 SHC1 IL4 CCND3 CCND2 JAK3 JAK1 ELF1 FOXP3 CCNA2 CDK6 IL2RA IL8- AND CXCR2-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL8- AND CXCR2-MEDIATED SIGNALING EVENTS IL8- and CXCR2-mediated signaling events CXCR2 PRKCA ARRB2 RAC2 DOCK2 RAB7A CXCL8 CBL ELMO1 PDPK1 PIK3CG PLD2 PIK3R6 RAB5A GNA14 GNA15 LYN FGR HCK PPP2CA AKT1 DNM1 PLCB2 RAB11A PPP2R1A VASP ARRB1 GNG2 PRKCG GNAI2 PLCB3 GNB1 PLCB1 PRKCB ERBB2 ERBB3 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB2 ERBB3 SIGNALING EVENTS ErbB2 ErbB3 signaling events PTPN11 NRG2 MAP2K1 MAP2K2 MAPK10 PIK3R1 GRB2 CHRNA1 SOS1 DOCK7 PPP3CB ERBB3 CHRNE RAF1 USP8 RNF41 NFATC4 BAD NF2 JAK2 MTOR CDC42 MAPK8 STAT3 NRG1 MAPK1 AKT1 RAC1 MAPK3 PIK3CA PRKACA MAPK9 JUN NRAS FOS SHC1 SRC PIK3CB HRAS ERBB2 KRAS FOXA TRANSCRIPTION FACTOR NETWORKS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXA TRANSCRIPTION FACTOR NETWORKS FOXA transcription factor networks FOXA1 FOXA3 FOXA2 PROTEOGLYCAN SYNDECAN-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PROTEOGLYCAN SYNDECAN-MEDIATED SIGNALING EVENTS Proteoglycan syndecan-mediated signaling events SDC2 SDC3 SDC1 SDC4 BETA3 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA3 INTEGRIN CELL SURFACE INTERACTIONS Beta3 integrin cell surface interactions VTN COL4A4 KDR COL4A3 PDGFRB COL4A6 SDC1 COL4A5 THY1 TGFBR2 PDGFB FN1 SPHK1 ITGB3 LAMC1 PLAU SPP1 COL1A2 ITGAV TNC HMGB1 IBSP VEGFA ITGA2B EDIL3 L1CAM CD47 FBN1 CYR61 PLAUR THBS1 LAMA4 FGG F11R LAMB1 FGB FGA TGFBI COL1A1 SDC4 PVR COL4A1 THROMBIN PROTEASE-ACTIVATED RECEPTOR (PAR) PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%THROMBIN PROTEASE-ACTIVATED RECEPTOR (PAR) PATHWAY Thrombin protease-activated receptor (PAR) pathway F2 IL2-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL2-MEDIATED SIGNALING EVENTS IL2-mediated signaling events DOK2 FYN PIK3R1 IL2RG SOCS1 SOCS3 STAT5B MAPKAPK2 MAPK14 STAT5A STAT1 STAT3 CISH MYC PIK3CA IKZF3 STAM2 SOCS2 STAM MAPK9 JUN NRAS FOS IRS1 IL2 SHC1 PRKCB IRS2 PRKCE HRAS IFNG IL2RA KRAS PTPN11 MAP2K1 MAP2K2 MAPK11 RASA1 GAB2 GRB2 SOS1 LCK RAF1 MAPK8 PTK2B MAPK1 CDK2 MAPK3 IL2RB SYK RHOA BCL2 JAK3 JAK1 GLYPICAN PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN PATHWAY Glypican pathway GPC2 GPC3 GPC1 CIRCADIAN RHYTHM PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CIRCADIAN RHYTHM PATHWAY Circadian rhythm pathway PER2 BHLHE40 PER1 CRY2 WDR5 CRY1 CLOCK ATR CSNK1E CHEK1 NONO NR1D1 TIMELESS NPAS2 ARNTL DEC1 IL12-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL12-MEDIATED SIGNALING EVENTS IL12-mediated signaling events RAB7A CD3E IL2RG SOCS1 STAT6 RELA IL18RAP STAT4 ATF2 IL12B MAPK14 JAK2 B2M IL12RB1 MTOR EOMES STAT5A NOS2 STAT1 STAT3 IL18 CD8B TYK2 CD8A NFKB1 CD4 IL1B GZMB FASLG IL18R1 CD3G CD3D TBX21 HLA-DRA FOS CD247 IL2 HLA-DRB1 IL4 HLA-A IFNG IL2RA MAP2K6 LCK CCR5 IL1R1 RELB HLX CCL4 CCL3 GADD45B GZMA IL12A NFKB2 IL12RB2 GADD45G IL2RB RIPK2 SPHK2 MAP2K3 BETA5 BETA6 BETA7 AND BETA8 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA5 BETA6 BETA7 AND BETA8 INTEGRIN CELL SURFACE INTERACTIONS Beta5 beta6 beta7 and beta8 integrin cell surface interactions VTN ITGAV EDIL3 FBN1 ITGB8 SDC1 ITGB7 PLAUR CYR61 ITGB6 ITGA4 MADCAM1 VCAM1 TGFBR1 FN1 ITGB5 PLAU INTEGRINS IN ANGIOGENESIS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTEGRINS IN ANGIOGENESIS Integrins in angiogenesis COL4A4 COL7A1 COL5A2 COL4A3 COL6A1 COL4A6 SDC1 COL4A5 COL6A3 PIK3R1 CBL TGFBR2 FN1 ROCK1 CDKN1B RPS6KB1 AKT1 EDIL3 PIK3CA IRS1 CSF1 SRC PXN CASP8 VTN PTPN11 IGF1R KDR PTK2 ITGB3 ILK SPP1 COL1A2 PTK2B MAPK1 PIK3C2A ITGAV ADGRA2 RAC1 VEGFA ANGPTL3 MAPK3 VAV3 MFGE8 PI4KB RHOA CSF1R BCAR1 FGF2 F11R COL11A1 HSP90AA1 COL11A2 COL1A1 COL3A1 COL2A1 COL5A1 COL4A1 TLN1 COL6A2 VCL SIGNALING EVENTS MEDIATED BY HDAC CLASS III%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HDAC CLASS III Signaling events mediated by HDAC Class III ACSS1 MEF2D PPARGC1A HIST1H4K HIST1H4L FOXO4 HIST1H4A FOXO3 TUBB2A FOXO1 HIST1H4B HIST4H4 HIST1H4H HIST1H4I HIST1H4J HIST1H4C HIST1H4D HIST1H4E HIST1H4F CREBBP SIRT7 CDKN1A SIRT1 SIRT2 XRCC6 SIRT3 EP300 TP53 KAT2B HDAC4 BAX FHL2 MYOD1 ACSS2 HIST2H4A HOXA10 TUBA1B HIST2H4B HIST1H1E RETINOIC ACID RECEPTORS-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RETINOIC ACID RECEPTORS-MEDIATED SIGNALING Retinoic acid receptors-mediated signaling CDK1 PRKCA NRIP1 RXRB RXRA RXRG CCNH CREBBP CDK7 MAPK14 RBP1 MNAT1 VDR RARG MAPK8 HDAC3 MAPK1 EP300 AKT1 MAPK3 NCOA1 RARA RARB NCOA2 PRKACA NCOR2 PRKCG KAT2B NCOA3 HDAC1 HYPOXIC AND OXYGEN HOMEOSTASIS REGULATION OF HIF-1-ALPHA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HYPOXIC AND OXYGEN HOMEOSTASIS REGULATION OF HIF-1-ALPHA Hypoxic and oxygen homeostasis regulation of HIF-1-alpha HIF1A OS9 COPS5 TP53 ARNT HSP90AA1 GNB2L1 TCEB2 TCEB1 HIF1AN VHL EGLN1 EGLN3 CDKN2A EGLN2 NAA10 CUL2 HIF3A RBX1 FOXA1 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXA1 TRANSCRIPTION FACTOR NETWORK FOXA1 transcription factor network PRDM15 INS VTN ATP5J KLK3 NRIP1 NDUFV3 SFTPA1 XBP1 BRCA1 SOD1 CREBBP CDKN1B FOXA1 ESR1 FOXA3 FOXA2 SP1 EP300 APOB SHH COL18A1 SERPINA1 SFTPA2 C4BPB CYP2C18 JUN POU2F1 SFTPD GCG AR DSCAM NR2F2 NCOA3 PISD AP1B1 FOS NFIA NFIB NFIC SCGB1A1 CEBPB TFF1 NKX3-1 NONCANONICAL WNT SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NONCANONICAL WNT SIGNALING PATHWAY Noncanonical Wnt signaling pathway DAAM1 TAB2 TAB1 ARRB2 DVL1 DVL2 YES1 MAPK10 CAMK2A DVL3 CSNK1A1 ROCK1 CDC42 CTHRC1 PPARG MAPK8 FZD2 MAP3K7 FZD5 RAC1 FZD7 FZD6 WNT5A RHOA ROR2 MAPK9 PRKCZ NLK NFATC2 CHD7 FLNA SETDB1 REGULATION OF NUCLEAR BETA CATENIN SIGNALING AND TARGET GENE TRANSCRIPTION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF NUCLEAR BETA CATENIN SIGNALING AND TARGET GENE TRANSCRIPTION Regulation of nuclear beta catenin signaling and target gene transcription MYF5 CUL1 SKP1 YWHAE YWHAB DVL3 CXCL8 YWHAQ CCND1 SFN MITF YWHAG YWHAH T TCF7L1 HBP1 YWHAZ CAMK4 MYC EP300 ID2 NCOA2 TLE1 JUN AR XPO1 AXIN2 RUVBL2 HDAC2 HDAC1 CTBP1 TCF7L2 VCAN INCENP SNAI2 CTNNB1 TCF4 ZCCHC12 CHD8 CBY1 FGF4 MED12 SALL4 PITX2 CYR61 MYOG MMP2 TLE4 MMP9 TLE2 DKK1 CTNNBIP1 KRT1 BTRC AES DKK4 TERT MDFIC TBL1XR1 LEF1 MT-CO2 TNIK TCF7 CDH1 ADCY7 APC CACNA1G IGF2BP1 TBL1X TRRAP CDX4 CDX1 CDKN2A KCNIP4 CCND2 KLF4 SMARCA4 BCL9 SP5 NEUROG1 PLASMA MEMBRANE ESTROGEN RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLASMA MEMBRANE ESTROGEN RECEPTOR SIGNALING Plasma membrane estrogen receptor signaling IGF1R GNAL PELP1 STRN MAPK11 HBEGF PIK3R1 GRB2 SOS1 ESR2 GNAI3 GNAI1 ROCK2 GNA14 GNA15 ESR1 GNAQ GNA11 NOS3 AKT1 PLCB2 PIK3CA MMP2 MMP9 RHOA GNAO1 BCAR1 GNAZ GNG2 GNAI2 GNA13 PLCB3 NRAS GNB1 MSN PLCB1 SHC1 SRC HRAS KRAS EPO SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPO SIGNALING PATHWAY EPO signaling pathway GAB1 PTPN11 SH2B3 EPOR TEC BTK PIK3R1 CBL GRB2 RAPGEF1 SOS1 PLCG1 EPO SOCS3 STAT5B MAPK14 JAK2 STAT5A CRKL MAPK8 LYN STAT1 PTPN6 BCL2L1 PLCG2 NFKB1 VAV2 BCL2 SHC1 IRS2 RAP1A HRAS P38 MAPK SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P38 MAPK SIGNALING PATHWAY p38 MAPK signaling pathway CALM3 TAB2 CALM1 TAB1 CALM2 MAP2K6 GADD45A MAPK11 MAP3K6 MAP3K4 TAOK3 TAOK1 TAOK2 MAP3K10 MAPK14 GADD45B GADD45G MAP3K7 RAC1 MAP3K1 ATM CAMK2B MAP2K3 MAP3K3 MAP3K5 TRAF2 TRAF6 CCM2 TXN C-MYC PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%C-MYC PATHWAY C-MYC pathway MAX ACTL6A RUVBL1 PAK2 SUPT7L SKP2 SUPT3H GSK3B TAF9 AK6 ZBTB17 PML HBP1 FBXW7 TAF12 PPP2R5A TAF10 MYC PPP2CA PIN1 KAT2A KAT5 TRRAP RUVBL2 CDKN2A AXIN1 S1P1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P1 PATHWAY S1P1 pathway VEGFA RAC1 PLCB2 MAPK3 KDR PDGFRB PTGS2 RHOA GNAO1 GNAZ PLCG1 GNAI2 GNAI3 PDGFB ABCC1 GNAI1 SPHK1 S1PR1 MAPK1 GLYPICAN 1 NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN 1 NETWORK Glypican 1 network FYN YES1 TGFB1 TGFB3 FLT1 LAMA1 LCK BLK SMAD2 TGFBR1 TGFBR2 SERPINC1 SLIT2 LYN PRNP PLA2G2A NRG1 TDGF1 FGR HCK VEGFA FGF2 GPC1 SRC APP FGFR1 ENDOTHELINS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ENDOTHELINS Endothelins GNAL PLA2G4A MAPK14 JAK2 PRKCD GNA14 GNA15 GNAQ GNA11 PRKCQ AKT1 PLCB2 EDNRA CYSLTR1 EDNRB CYSLTR2 PRKCG PRKCH JUN TRPC6 EDN2 EDN3 PLCB3 ADCY9 ADCY4 FOS ADCY3 PLCB1 ADCY2 ADCY1 SRC ADCY8 PRKCB ADCY6 PRKCE ADCY5 EDN1 HRAS PRKCA MAP2K1 MAP2K2 CRK RAF1 GNAI3 GNAI1 CDC42 MAPK8 COL1A2 PTK2B MAPK1 RAC1 MAPK3 SLC9A1 RHOA GNAO1 BCAR1 GNAZ GNA12 GNAI2 ADCY7 MMP1 SLC9A3 COL3A1 VEGF AND VEGFR SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VEGF AND VEGFR SIGNALING NETWORK VEGF and VEGFR signaling network NRP1 FIGF NRP2 VEGFA FLT4 VEGFB KDR PGF VEGFC FLT1 NEPHRIN NEPH1 SIGNALING IN THE KIDNEY PODOCYTE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NEPHRIN NEPH1 SIGNALING IN THE KIDNEY PODOCYTE Nephrin Neph1 signaling in the kidney podocyte F2RL2 ARRB2 WASL NCK2 FYN TJP1 MAPK10 KIRREL CD2AP NPHS1 PIK3R1 NPHS2 GRB2 PLCG1 BAD MAPK8 AKT1 RAC1 PIK3CA PARD6A MAP2K4 MAPK9 PRKCZ JUN TRPC6 PIK3CB PRKCI NCK1 LPA RECEPTOR MEDIATED EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LPA RECEPTOR MEDIATED EVENTS LPA receptor mediated events GSK3B CXCL8 HBEGF PIK3R1 PLCG1 RELA MAPT PRKCD PLD2 GNA14 GNA15 LYN GNAQ GNA11 NFKB1 AKT1 NFKBIA GNG2 JUN PLCB3 ADCY9 ADCY4 GNB1 FOS ARHGEF1 ADCY3 ADCY2 ADCY1 SRC ADCY8 PXN ADCY6 PRKCE ADCY5 PIK3CB HRAS CASP3 GAB1 PTK2 TIAM1 SLC9A3R2 TRIP6 CRK ADRA1B GNAI3 LPAR1 LPAR2 LPAR3 GNAI1 LPAR4 EGFR PTK2B RAC1 MMP2 MMP9 RHOA GNAO1 BCAR1 GNAZ GNA12 GNAI2 GNA13 ADCY7 PRKD1 UROKINASE-TYPE PLASMINOGEN ACTIVATOR (UPA) AND UPAR-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%UROKINASE-TYPE PLASMINOGEN ACTIVATOR (UPA) AND UPAR-MEDIATED SIGNALING Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling VTN PDGFRB TGFB1 CRK DOCK1 FN1 EGFR ITGB5 ITGB3 SERPINE1 ITGA3 PLAU ITGB1 ITGAM LRP1 ITGAV ITGB2 RAC1 FPR1 KLK4 FPR3 FPR2 VLDLR PDGFD CTSG PLAUR MMP9 MMP12 MMP13 NCL CTRC FGG GPLD1 BCAR1 MMP3 FGB FGA PLG ITGA5 ELANE SRC HGF VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL REPRESSION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL REPRESSION Validated targets of C-MYC transcriptional repression GFI1 CLU FTH1 HMGCS2 TBP SLC11A1 CCND1 DNMT3A TSC2 SFRP1 TMEFF2 CSDE1 TMEM126A S100A7 ALDH9A1 NDRG2 CDKN1A CDKN1B NDRG1 ZFP36L1 NFYA NFYB NFYC GTF2H2 SFXN3 HDAC3 TJP2 MXD4 ITGB1 MYC ITGB4 EP300 ID2 ITGA6 LGALS1 RBL1 CREB1 HDAC1 DDIT3 MAX FOXO3 PDGFRB GADD45A CFLAR SMAD2 BRCA1 ZBTB17 CDKN2B SMAD4 SMAD3 COL1A2 SP1 PPP2R4 WNT5A DKK1 IRF8 CEBPA CEBPD CCL5 BCL2 SPI1 DNTT ERBB2 BETA1 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA1 INTEGRIN CELL SURFACE INTERACTIONS Beta1 integrin cell surface interactions COL4A4 COL7A1 COL5A2 COL4A3 COL6A1 COL4A6 COL4A5 COL6A3 LAMA1 LAMA3 FN1 LAMC1 ITGA3 ITGB1 NPNT NID1 CSPG4 FBN1 IGSF8 CD81 ITGA4 THBS2 ITGA2 THBS1 COL18A1 ITGA1 MDK LAMA4 LAMB3 LAMA2 CD14 ITGA10 LAMB2 ITGA11 ITGA8 LAMB1 LAMC2 ITGA7 JAM2 ITGA6 VCAM1 ITGA5 ITGA9 VTN PLAU SPP1 COL1A2 ITGAV TNC VEGFA F13A1 TGM2 PLAUR FGG LAMA5 FGB COL11A1 FGA COL11A2 TGFBI COL1A1 COL3A1 COL2A1 COL5A1 COL4A1 COL6A2 ERBB RECEPTOR SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB RECEPTOR SIGNALING NETWORK ErbB receptor signaling network NRG2 EREG AREG BTC NRG3 NRG4 HBEGF TGFA ERBB3 HSP90AA1 EGFR NRG1 EGF ERBB4 ERBB2 SIGNALING EVENTS MEDIATED BY HDAC CLASS II%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HDAC CLASS II Signaling events mediated by HDAC Class II TUBB2A YWHAE YWHAB HDAC10 HDAC11 ESR1 CAMK4 NR3C1 HDAC5 BCL6 HDAC3 GATA2 GATA1 HDAC9 HDAC6 HDAC7 SRF MEF2C RFXANK BCOR ANKRA2 ADRBK1 GNG2 NCOR2 HSP90AA1 HDAC4 GNB1 RANBP2 UBE2I XPO1 SUMO1 RANGAP1 RAN TUBA1B TGF-BETA RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TGF-BETA RECEPTOR SIGNALING TGF-beta receptor signaling TAB2 TAB1 ARRB2 YWHAE TGFB1 YAP1 CAMK2A TGFB3 CAV1 TGFBR1 TGFBR2 PML PPP1CA PDPK1 RPS6KB1 WWP1 ITCH SMURF1 SHC1 FKBP1A ZFYVE9 PPP2R2A DACT2 RNF111 EIF2A TGFBR3 ZFYVE16 STRAP PPP1R15A NEDD4L PPP2CB SPTBN1 SMURF2 DAB2 OCLN BAMBI DYNLRB1 GRB2 SOS1 XIAP SMAD2 CTNNB1 SMAD4 SMAD3 SMAD7 MAP3K7 PPP2CA CTGF DAXX PARD6A AXIN1 ALPHAE BETA7 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHAE BETA7 INTEGRIN CELL SURFACE INTERACTIONS AlphaE beta7 integrin cell surface interactions ITGAE CDH1 ITGB7 JNK SIGNALING IN THE CD4+ TCR PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%JNK SIGNALING IN THE CD4+ TCR PATHWAY JNK signaling in the CD4+ TCR pathway MAP3K1 GRAP2 MAP4K1 LAT MAP2K4 DBNL CRK JUN PRKCB CRKL MAPK8 MAP3K8 LCP2 MAP3K7 ROLE OF CALCINEURIN-DEPENDENT NFAT SIGNALING IN LYMPHOCYTES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ROLE OF CALCINEURIN-DEPENDENT NFAT SIGNALING IN LYMPHOCYTES Role of Calcineurin-dependent NFAT signaling in lymphocytes MEF2D YWHAE GSK3B YWHAB YWHAQ SFN YWHAG YWHAH BAD MAPK14 PRKCD KPNB1 YWHAZ CAMK4 MAP3K8 CSNK2A1 BCL2L1 EP300 PRKCQ AKAP5 CABIN1 CHP1 PRKACA MAPK9 PRKCZ PRKCG PRKCH NFATC3 NFATC2 NFATC1 XPO1 FKBP1A PRKCB PRKCE RCAN1 RAN RCAN2 CASP3 CALM3 CALM1 CALM2 PRKCA CSNK1A1 KPNA2 NUP214 FKBP8 CREBBP PIM1 MAPK8 MAPK3 MAP3K1 NR4A1 BCL2 TCR SIGNALING IN NAIVE CD4+ T CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TCR SIGNALING IN NAIVE CD4+ T CELLS TCR signaling in naive CD4+ T cells VAV1 FYN CBL CD3E PLCG1 CARD11 BCL10 ITK MALT1 PDPK1 MAP3K8 PTPRC LCP2 PTPN6 PRKCQ AKT1 CD4 CD86 CD80 CD3G CD3D RASGRP2 RASGRP1 TRAF6 CD28 NRAS HLA-DRA CD247 HLA-DRB1 SHC1 PRKCB PRKCE RAP1A IKBKB HRAS FLNA NCK1 KRAS IKBKG CSK PTPN11 PRKCA GRAP2 MAP4K1 TRPV6 LAT GAB2 GRB2 DBNL SOS1 LCK CDC42 PAG1 SLA2 RASSF5 STIM1 ORAI1 WAS STK39 FYB SH3BP2 ZAP70 PTEN CHUK MAP3K14 VEGFR1 SPECIFIC SIGNALS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VEGFR1 SPECIFIC SIGNALS VEGFR1 specific signals NRP1 CALM3 NRP2 SHC2 PTPN11 CALM1 CALM2 VEGFB PRKCA PGF CAV1 CD2AP RASA1 PIK3R1 CBL FLT1 PLCG1 PDPK1 NOS3 MAPK1 HIF1A AKT1 VEGFA MAPK3 PIK3CA PRKACA HSP90AA1 PRKCB NCK1 EGFR-DEPENDENT ENDOTHELIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EGFR-DEPENDENT ENDOTHELIN SIGNALING EVENTS EGFR-dependent Endothelin signaling events EGFR SHC1 MTOR EDNRA EDN1 GRB2 EGF SOS1 HRAS HEDGEHOG SIGNALING EVENTS MEDIATED BY GLI PROTEINS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HEDGEHOG SIGNALING EVENTS MEDIATED BY GLI PROTEINS Hedgehog signaling events mediated by Gli proteins ARRB2 CSNK1G3 GSK3B RBBP4 MAP2K1 SAP18 CSNK1A1 CSNK1D RBBP7 CSNK1E GNAI3 CSNK1G2 CSNK1G1 CREBBP GNAI1 PRKCD FOXA2 SIN3B SIN3A AKT1 PTCH1 GLI2 SHH SMO BTRC PRKACA GNAO1 GNAZ IFT172 GNG2 GLI1 GLI3 SAP30 GNAI2 KIF3A STK36 LGALS3 RAB23 SUFU FBXW11 GNB1 SPOP MTSS1 XPO1 IFT88 HDAC2 PIAS1 HDAC1 INSULIN PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INSULIN PATHWAY Insulin Pathway INS EXOC4 F2RL2 PTPN11 PTPN1 INSR EXOC3 EXOC6 FOXO3 NCK2 EXOC5 DOK1 EXOC2 EXOC1 EIF4EBP1 CAV1 RASA1 PIK3R1 CBL GRB2 RAPGEF1 SOS1 CRK SGK1 PDPK1 RPS6KB1 TRIP10 RHOQ AKT1 PIK3CA PARD6A AKT2 PRKCZ GRB14 PTPRA IRS1 SHC1 EXOC7 SORBS1 GRB10 PRKCI HRAS NCK1 PDGF RECEPTOR SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PDGF RECEPTOR SIGNALING NETWORK PDGF receptor signaling network PDGFB PDGFRB PDGFD PDGFA PDGFRA PDGFC LISSENCEPHALY GENE (LIS1) IN NEURONAL MIGRATION AND DEVELOPMENT%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LISSENCEPHALY GENE (LIS1) IN NEURONAL MIGRATION AND DEVELOPMENT Lissencephaly gene (LIS1) in neuronal migration and development CALM3 CALM1 CALM2 YWHAE ABL1 PLA2G7 LRP8 RELN KATNA1 NDEL1 DYNC1H1 MAP1B CLIP1 DAB1 DCX PAFAH1B3 CDK5R2 PAFAH1B2 PAFAH1B1 CDK5R1 CDC42 CSNK2A1 LRPAP1 RAC1 CDK5 VLDLR PPP2R5D RHOA IQGAP1 NUDC DYNLT1 ERBB1 DOWNSTREAM SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB1 DOWNSTREAM SIGNALING ErbB1 downstream signaling F2RL2 YWHAE YWHAB YWHAQ PIK3R1 SFN YWHAG YWHAH EGR1 BAD PDPK1 PRKCD YWHAZ BRAF ELK1 STAT1 STAT3 RALGDS MAP2K5 MYLPF PIK3CA PPP5C DIAPH3 ARF4 DUSP6 MAPK7 MAP3K2 MAPKAP1 MAPK9 PRKCZ MLST8 JUN RICTOR NRAS FOS PIK3CB DUSP1 KRAS RIN1 CALM3 CYFIP2 CALM1 NCKAP1 CALM2 WASF2 USP6NL ABI1 PEBP1 CDC42 MAPK8 MAPK1 VAV2 RAC1 PPP2CA MAPK3 MAP3K1 PPP2R1A MAP2K4 KSR1 ATF1 WASL RPS6KA4 SMAD1 RPS6KA5 PLD1 ATF2 PLD2 RAB5A MTOR BCL2L1 AKT1 MEF2C CREB1 SRC ARPC1B RPS6KA3 BRK1 PPP2R2A SH2D2A HRAS ACTR3 ACTR2 GAB1 RALA PRKCA ARPC4 ARPC5 MAP2K1 BAIAP2 MAP2K2 ARPC2 ARPC3 GRB2 SOS1 RAF1 EGFR EGF CAPN2 SRF SLC9A1 IQGAP1 RPS6 EPS8 CHN2 SIGNALING EVENTS MEDIATED BY PRL%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY PRL Signaling events mediated by PRL CDK2 RAC1 CCNE1 MAPK3 AGT RHOA ITGA1 BCAR1 RHOC RABGGTB EGR1 RABGGTA PTP4A1 ROCK1 PTP4A2 CDKN1A PTP4A3 ATF5 SRC TUBA1B ITGB1 CCNA2 MAPK1 EPHA2 FORWARD SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHA2 FORWARD SIGNALING EPHA2 forward signaling VAV2 EFNA1 RAC1 ARHGAP35 VAV3 PIK3CA PTK2 PAK1 EPHA2 TIAM1 RHOA PIK3R1 CBL GRB2 BCAR1 SHC1 SRC ACP1 INPPL1 VEGFR3 SIGNALING IN LYMPHATIC ENDOTHELIUM%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VEGFR3 SIGNALING IN LYMPHATIC ENDOTHELIUM VEGFR3 signaling in lymphatic endothelium FLT4 MAPK11 PIK3R1 GRB2 SOS1 CRK FN1 RPS6KA1 MAPK14 COL1A2 ITGB1 MAPK1 FIGF AKT1 MAPK3 PIK3CA VEGFC ITGA4 ITGA2 ITGA1 MAP2K4 ITGA5 SHC1 CREB1 COL1A1 EPHRIN B REVERSE SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRIN B REVERSE SIGNALING Ephrin B reverse signaling NCK2 FYN YES1 TIAM1 PIK3R1 LCK BLK ITGB3 EFNB2 EFNB1 MAPK8 LYN EPHB2 MAP3K7 EPHB1 FGR EPHB4 HCK PTPN13 RAC1 DNM1 ITGA2B PIK3CA MAP2K4 SRC RGS3 ARF6 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF6 SIGNALING EVENTS Arf6 signaling events AGTR1 KIF13B ARRB2 FBXO8 LHCGR USP6 IQSEC1 ARF6 ARAP2 IPCEF1 GULP1 ACAP2 MET EGFR ITGB3 GNA14 GNA15 GNAQ CYTH3 GNA11 CYTH2 EGF EFNA1 ITGA2B ADAP1 EPHA2 ARRB1 GIT1 ADRB2 SRC HGF PXN TSHR ACAP1 NCK1 P73 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P73 TRANSCRIPTION FACTOR NETWORK p73 transcription factor network TP63 WWOX TP73 DCP1B CDK1 ADA YAP1 SFN RELA PML RB1 GNB2L1 CDKN1A SIRT1 MAPK14 SERPINE1 PPAP2A MYC GATA1 EP300 ITCH FASN HEY2 SERPINA1 PRKACB KAT5 MDM2 CCNA2 BCL2L11 CASP2 NEDD4L FOXO3 RCHY1 ABL1 MAPK11 FAS BRCA2 CHEK1 NTRK1 TP53AIP1 SP1 CDK2 RAD51 CCNB1 IL1RAP BBC3 TUBA1A PEA15 FLOT2 RNF43 PIN1 S100A2 BUB1 UBE4B AEN CCNE2 PLK3 NDUFS2 HAGH PFDN5 FBXO45 JAG2 AFP PLK1 GRAMD4 BAX HSF1 CLCA2 BUB3 BAK1 DEDD GDF15 JAK1 TP53I3 IL4R BIN1 CDK6 WT1 CXCR3-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CXCR3-MEDIATED SIGNALING EVENTS CXCR3-mediated signaling events MAP2K6 CXCL9 CXCL13 MAP2K1 CXCR3 MAP2K2 CCL11 MAPK11 CXCL10 CXCL11 PF4 PIK3R1 RAF1 GNAI3 GNAI1 PDPK1 MAPK14 MTOR MAPK1 AKT1 DNM1 MAPK3 PIK3CA ARRB1 MAPKAP1 GNAO1 GNAZ GNG2 MLST8 RICTOR MAP2K3 GNAI2 NRAS GNB1 SRC PIK3CB HRAS KRAS IL3-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL3-MEDIATED SIGNALING EVENTS IL3-mediated signaling events PTPN11 GAB2 PIK3R1 GRB2 SRP9 YWHAG CNKSR1 IL3RA STAT5B ID1 JAK2 STAT5A YWHAZ PIM1 CISH BCL2L1 CSF2RB PIK3CA PRKACG OSM PRKACA PRKACB SHC1 IL3 CEBPB HDAC1 THROMBOXANE A2 RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%THROMBOXANE A2 RECEPTOR SIGNALING Thromboxane A2 receptor signaling ARRB2 FYN YES1 ARR3 BLK ROCK1 PTGDR MAPK14 PIK3CG PTGIR PRKCD PIK3R6 TBXA2R GNA14 GNA15 LYN GNAQ GNA11 FGR HCK GNB5 PRKCQ AKT1 DNM1 PLCB2 RAB11A PRKACA GNG2 PRKCZ ADRBK2 PRKCG PRKCH VCAM1 GNB1 ARHGEF1 SRC PRKCB PRKCE PRKCA SELE MAPK11 SLC9A3R1 LCK EGFR EGF NOS3 RAC1 TGM2 ICAM1 SYK RHOA ADRBK1 GNA12 GNAI2 GNA13 A6B1 AND A6B4 INTEGRIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%A6B1 AND A6B4 INTEGRIN SIGNALING a6b1 and a6b4 Integrin signaling CASP7 PRKCA YWHAE YWHAB RXRB RXRA YWHAQ RXRG PIK3R1 GRB2 LAMA1 SFN MET LAMA3 ERBB3 YWHAG YWHAH EGFR YWHAZ LAMC1 RPS6KB1 COL17A1 PMP22 EGF CD9 ITGB1 IL1A ITGB4 AKT1 RAC1 MST1R PIK3CA LAMA4 LAMB3 LAMA2 LAMB2 LAMA5 LAMB1 LAMC2 ITGA6 CDH1 SHC1 HRAS ERBB2 MTOR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%MTOR SIGNALING PATHWAY mTOR signaling pathway YWHAE YWHAB EIF4EBP1 YWHAQ EIF4E TSC2 SFN RPTOR YWHAG CLIP1 DEPTOR YWHAH EEF2K AKT1S1 PLD1 PML RPS6KA1 PDPK1 PLD2 MTOR YWHAZ BRAF RPS6KB1 AKT1 YY1 MAPKAP1 MLST8 PRR5 RICTOR RB1CC1 TSC1 ATG13 RRAGA NRAS RRAGC IRS1 RRAGB RRAGD DDIT4 ULK2 ULK1 RRN3 IKBKB POLDIP3 HRAS EIF4B BNIP3 EEF2 KRAS RHEB PDCD4 PPARGC1A PRKCA MAP2K1 MAP2K2 RAF1 SGK1 MAPK1 SREBF1 CDK2 CCNE1 MAPK3 BTRC FBXW11 EIF4A1 CYCS ALTERNATIVE NF-KAPPAB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALTERNATIVE NF-KAPPAB PATHWAY Alternative NF-kappaB pathway NFKB1 RELB CHUK NFKB2 MAP3K14 BTRC DIRECT P53 EFFECTORS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DIRECT P53 EFFECTORS Direct p53 effectors MSH2 DDX5 PCBP4 TP53BP2 SCN3B BCL2L14 SH2D1A TNFRSF10C TNFRSF10B TNFRSF10A TNFRSF10D TADA2B RGCC TAF9 JMY SFN BCL2L2 MET BTG2 AK6 PPP1R13B TRIAP1 CX3CL1 PML RB1 LIF AIFM2 DGCR8 ZNF385A GPX1 PMAIP1 PRMT1 FOXA1 DDB2 E2F3 RNF144B RRM2B IRF5 TYRP1 RPS27L HTT PPM1J NLRC4 MAP4K4 TP53INP1 PMS2 E2F2 DROSHA BCL2L2-PABPN1 TIGAR ARID3A MLH1 CEBPZ TGFA JUN EDN2 HSPA1B HSPA1A MDM2 DUSP5 DUSP1 CASP10 SERPINB5 BID VCAN RCHY1 GADD45A SNAI2 FAS CARM1 SPP1 CCNB1 EPHA2 MMP2 BBC3 CTSD S100A2 PLK3 AFP BAX BAK1 GDF15 TP53I3 TP63 TP73 CAV1 TSC2 BCL2A1 PERP BDKRB2 NDRG1 CDKN1A NFYA SERPINE1 IGFBP3 NFYB NFYC BCL6 BCL2L1 EP300 COL18A1 CD82 KAT2A TFDP1 DDIT4 ATF3 HDAC2 PIDD1 CASP1 APAF1 PCNA POU4F1 POU4F2 CREBBP CASP6 EGFR VDR CSE1L SP1 TP53 PTEN DKK1 RFWD2 MCL1 CCNG1 E2F1 BCL2 APC CCNK STEAP3 TRRAP PRDM1 HGF PYCARD SESN1 FDXR BNIP3L SMARCA4 TAP1 PRKAB1 HIC1 POSTTRANSLATIONAL REGULATION OF ADHERENS JUNCTION STABILITY AND DISSASSEMBLY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%POSTTRANSLATIONAL REGULATION OF ADHERENS JUNCTION STABILITY AND DISSASSEMBLY Posttranslational regulation of adherens junction stability and dissassembly PTPN1 GFRA1 IGF1R JUP ABL1 RAB7A FYN GDNF ARF6 TIAM1 MET CTNNB1 CREBBP RIN2 EGFR RAB5A CDC42 NTRK2 EGF PTPN6 BDNF RAC1 ADAM10 SNX1 CTNND1 GNA12 MMP3 IQGAP1 ROBO1 GNA13 SLIT1 RET CDH1 DSP CTNNA1 IGF2 MMP7 CABLES1 ZBTB33 SRC MEP1B CBLL1 CDH2 NME1 HGS HRAS DNM2 CASP3 LPA4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LPA4-MEDIATED SIGNALING EVENTS LPA4-mediated signaling events GNAL RPS6KA5 PRKACA ADCY9 ADCY4 ADCY7 ADCY3 ADCY2 LPAR4 ADCY1 CREB1 ADCY8 ADCY6 PRKCE ADCY5 AURORA A SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AURORA A SIGNALING Aurora A signaling DLGAP5 TDRD7 CPEB1 AURKAIP1 GSK3B AURKB GADD45A RASA1 NDEL1 CKAP5 BRCA1 TACC3 CENPA AJUBA AURKA AKT1 NFKBIA PAK1 PPP2R5D TP53 FZR1 BIRC5 TACC1 PRKACA GIT1 ARHGEF7 MDM2 CDC25B TPX2 RAN OAZ1 CD40 CD40L SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CD40 CD40L SIGNALING CD40 CD40L signaling MAPK10 MAPK11 CD40 TNFAIP3 C4BPA PIK3R1 FCAMR BIRC2 TDP2 TRAF3 RELA MAPK14 CBLB PIK3CG PIK3R6 STAT5A MAPK8 BCL2L1 MYC NFKB1 AKT1 NFKBIA MAP3K1 PIK3CA MAP3K14 BIRC3 MAP2K4 TRAF1 MAPK9 JUN TRAF2 TRAF6 IL4 PIK3CB JAK3 CD40LG VALIDATED NUCLEAR ESTROGEN RECEPTOR BETA NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED NUCLEAR ESTROGEN RECEPTOR BETA NETWORK Validated nuclear estrogen receptor beta network NEDD8 C3 NCOA1 NCOA2 SMARCE1 NR0B2 NR0B1 ESR2 SMARCB1 UBA3 ZNF14 NCOA3 UBE2M DDX54 SMARCA4 SIGNALING BY AURORA KINASES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING BY AURORA KINASES Signaling by Aurora kinases AURKC AURKB AURKA LKB1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LKB1 SIGNALING EVENTS LKB1 signaling events YWHAE GSK3B YWHAB YWHAQ EZR TSC2 SFN RPTOR YWHAG YWHAH AKT1S1 CDC37 MAPT SMAD4 MTOR YWHAZ ESR1 MYC BRSK1 BRSK2 TP53 CRTC2 SMARCD3 CAB39 PSEN2 STK11 CTSD MAP2 MARK4 PRKACA STRADA MLST8 STK11IP STRADB HSP90AA1 ETV4 TSC1 STK26 SIK1 MARK2 SIK2 CREB1 EPHRINB-EPHB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRINB-EPHB PATHWAY EphrinB-EPHB pathway EFNB2 EFNB1 EPHB2 EPHB1 EPHB4 EPHB3 TRK RECEPTOR SIGNALING MEDIATED BY THE MAPK PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TRK RECEPTOR SIGNALING MEDIATED BY THE MAPK PATHWAY Trk receptor signaling mediated by the MAPK pathway MAP2K6 MAP2K1 RPS6KA5 RIT1 EHD4 RIT2 RAF1 EGR1 MAPKAPK2 RPS6KA1 MAPK14 PRKCD TRPV1 CDK5R1 NTF3 RAP1B BRAF ELK1 MAPK1 MAPK3 MAP2K5 CDK5 SRF MAPK7 MEF2C MAP3K2 MAP2K3 NRAS FOS RUSC1 CREB1 RAP1A HRAS KRAS TNF RECEPTOR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TNF RECEPTOR SIGNALING PATHWAY TNF receptor signaling pathway RIPK1 RFFL IKBKG MAP4K3 TAB2 FADD MAP4K2 TAB1 TNFRSF1B MAP2K7 CYLD NSMAF ADAM17 CAV1 TNFAIP3 BIRC2 TNF RELA GNB2L1 STAT1 MAP3K7 MAP4K4 NFKB1 MAP3K1 TRADD CHUK BAG4 BIRC3 TRAF1 SMPD2 PRKCZ SMPD1 MAP2K3 MAP3K3 MAP3K5 TRAF2 TNIK TNFRSF1A MADD IKBKB PRKCI CASP8 NRK TXN SQSTM1 FOXA2 AND FOXA3 TRANSCRIPTION FACTOR NETWORKS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXA2 AND FOXA3 TRANSCRIPTION FACTOR NETWORKS FOXA2 and FOXA3 transcription factor networks INS G6PC FOXA1 FOXA3 NR3C1 FOXA2 HNF4A SP1 ACADVL ALAS1 AKT1 TAT SLC2A2 TTR UCP2 NKX2-1 ACADM HADH PCK1 IGFBP1 CPT1A HMGCS1 CEBPA PKLR KCNJ11 CEBPD ABCC8 FOXF1 F2 PDX1 APOA1 HNF1A CPT1C CPT1B AFP GCK TFRC CREB1 BDH1 DLK1 ALB ALDOB CEBPB NF1 CDC42 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CDC42 SIGNALING EVENTS CDC42 signaling events F2RL2 WASL GSK3B YES1 PIK3R1 CBL PLD1 ATF2 MAPK14 MTOR PAK4 BRAF RPS6KB1 PIK3CA DIAPH3 RASGRF1 MAPK9 PRKCZ JUN SRC ARPC1B PRKCE ARHGDIA HRAS ACTR3 ACTR2 PAX6 SEPT2 HES5 IQGAP3 TNK2 CDC42BPA MAP2K7 PAK2 MAP2K6 ARPC4 ARPC5 ENAH BAIAP2 TIAM1 ARPC2 DLG1 ARPC3 MAP3K11 RAF1 CTNNB1 CDC42 MAPK8 MAPK1 VAV2 RAC1 MAPK3 MAP3K1 PAK1 PARD6A CFL1 MAP2K4 BCAR1 MAP2K3 IQGAP1 LIMK2 CDH1 LIMK1 APC CTNNA1 ARHGEF7 EXOC7 ARHGEF6 EPS8 MYL2 CXCR4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CXCR4-MEDIATED SIGNALING EVENTS CXCR4-mediated signaling events VAV1 ARRB2 FYN YES1 PIK3R1 CD3E ARR3 BLK STAT5B BAD GNB2L1 PDPK1 PIK3CG JAK2 PIK3R6 MTOR SSH1 STAT5A RAP1B LYN STAT1 PTPRC STAT3 FGR PTPN6 HCK ITCH AKT1 DNM1 PLCB2 CXCR4 CD4 PIK3CA MAPKAP1 CD3G CD3D GNG2 MLST8 PRKCZ RICTOR PLCB3 GNB1 HLA-DRA CD247 PLCB1 HLA-DRB1 SRC PXN PIK3CB HGS CXCL12 CSK PTPN11 RALB PTK2 FOXO1 RGS1 VPS4B VPS4A GRK6 UBQLN1 LCK CRK GNAI3 GNAI1 CDC42 PAG1 STAT2 PTK2B RAC1 PAK1 MMP9 RHOA CFL1 ADRBK1 GNAO1 BCAR1 GNAZ RHOC GNAI2 RHOB GNA13 LIMK1 P38 SIGNALING MEDIATED BY MAPKAP KINASES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P38 SIGNALING MEDIATED BY MAPKAP KINASES p38 signaling mediated by MAPKAP kinases TCF3 HSPB1 YWHAE SRF YWHAB MAPK11 YWHAQ TSC2 SFN ETV1 RAF1 YWHAG LSP1 YWHAH MAPKAPK3 MAPKAPK2 MAPK14 CREB1 YWHAZ CDC25B TH PRESENILIN ACTION IN NOTCH AND WNT SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PRESENILIN ACTION IN NOTCH AND WNT SIGNALING Presenilin action in Notch and Wnt signaling CTBP1 TAB1 GSK3B DVL1 CSNK1A1 NEDD4 CCND1 CTNNB1 LRP6 CREBBP NKD1 WIF1 NOTCH1 FRAT1 DKK2 FZD1 MAP3K7 CSNK2A1 RBPJ MYC MAPK1 MAPK3 PSENEN PPP2R5D PSEN1 PPARD KREMEN2 APH1A TLE1 DKK1 NCSTN ADAM10 APH1B BTRC AES DTX1 JUN DLL1 NLK HNF1A WNT1 FBXW11 APC FOS AXIN1 HDAC1 VALIDATED TRANSCRIPTIONAL TARGETS OF TAP63 ISOFORMS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TRANSCRIPTIONAL TARGETS OF TAP63 ISOFORMS Validated transcriptional targets of TAp63 isoforms TP63 ADA YWHAQ PERP PML EGR2 CDKN1A HBP1 GPX2 PRKCD PMAIP1 IGFBP3 ITGA3 WWP1 ITGB4 EP300 ITCH CABLES1 MDM2 IKBKB SERPINB5 ABL1 GADD45A FAS VDR SP1 OGG1 MFGE8 NOC2L DST DICER1 CHUK TRAF4 SPATA18 SMARCD3 BBC3 SHH EVPL NQO1 TFAP2C FLOT2 SSRP1 BTRC DHRS3 S100A2 AEN JAG1 PLK1 BAX CLCA2 CDKN2A FDXR GDF15 TP53I3 IFN-GAMMA PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IFN-GAMMA PATHWAY IFN-gamma pathway CALM3 PTPN11 CALM1 PTPN2 CALM2 CASP1 MAP2K1 CAMK2A IFNGR1 DAPK1 PIK3R1 CBL MAP3K11 RAPGEF1 SOCS1 CAMK2D CREBBP JAK2 PRKCD MTOR CRKL RAP1B SMAD7 STAT1 STAT3 MAPK1 EP300 AKT1 MAPK3 MAP3K1 PIK3CA PIAS4 IL1B CAMK2B PTGES2 IRF9 IRF1 CAMK2G RAP1A CEBPB PIAS1 IFNG JAK1 ARF1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF1 PATHWAY Arf1 pathway CLTB AP2A1 RAC1 ARFGAP1 ASAP1 CD4 GGA3 ARFIP2 AP2M1 ARF1 COPA CLTA PLD2 KDELR1 GOSR2 CYTH2 PIP5K1A USO1 GBF1 IL1-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL1-MEDIATED SIGNALING EVENTS IL1-mediated signaling events IRAK4 IKBKG TAB2 TAB1 CASP1 IRAK1 MAP2K6 PIK3R1 MYD88 IL1RN ERC1 TICAM2 RELA IL1R2 IL1R1 IRAK3 TOLLIP UBE2V1 MAPK8 MAP3K7 IL1A NFKB1 PIK3CA IL1B CHUK IL1RAP UBE2N PRKCZ JUN MAP3K3 TRAF6 IKBKB PRKCI SQSTM1 INTERNALIZATION OF ERBB1%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTERNALIZATION OF ERBB1 Internalization of ErbB1 PTK2 SPRY2 PIK3R1 CBL GRB2 SOS1 SH3KBP1 UBE2D3 RAF1 USP8 ITSN1 CBLB EGFR EPS15 RAB5A CDC42 TSG101 UBE2D2 UBE2D1 ZFYVE28 EGF EPN1 CHMP3 AMPH DNM1 STAMBP SYNJ1 PIK3CA SH3GL2 NRAS ARHGEF7 SHC1 SRC PIK3CB HGS HRAS LRIG1 KRAS GLUCOCORTICOID RECEPTOR REGULATORY NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLUCOCORTICOID RECEPTOR REGULATORY NETWORK Glucocorticoid receptor regulatory network GSK3B TBP CXCL8 SFN RELA YWHAH STAT5B EGR1 CDKN1A MAPK14 CDK5R1 STAT5A NR3C1 TSG101 STAT1 KRT5 EP300 NFKB1 AKT1 IL6 KRT14 NCOA1 BGLAP PPP5C CSF2 NCOA2 PRKACA VIPR1 MAPK9 SUV420H1 PRKACB TBX21 SUMO2 IL13 JUN POU1F1 POU2F1 SMARCC2 IRF1 FKBP5 SMARCD1 NFATC1 FOS NR1I3 CGA IL2 CREB1 PCK2 CSN2 PBX1 PRL IL4 KRT17 MDM2 HDAC2 IFNG SMARCC1 HDAC1 GATA3 FKBP4 SELE MAPK10 MAPK11 SGK1 CREBBP MAPK8 IL5 MAPK1 MAPK3 NR4A1 CDK5 ICAM1 TP53 POMC PRKACG FGG HSP90AA1 SPI1 AFP MMP1 BAX SMARCA4 E2F TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E2F TRANSCRIPTION FACTOR NETWORK E2F transcription factor network TP73 CDK1 CDC25A PRMT5 RB1 CDKN1A CDKN1B SIRT1 HBP1 SERPINE1 E2F3 MYC EP300 YY1 E2F2 RBBP8 TFE3 KAT2B KAT2A XRCC1 TFDP1 RBL1 CCND3 CCNA2 HDAC1 CASP7 WASF1 RBBP4 APAF1 E2F4 RBL2 E2F5 UXT MYBL2 BRCA1 SULT2A1 CES4A TFDP2 TOPBP1 MCM3 CREBBP TRIM28 CES3 CES2 CES1 TYMS CES5A ORC1 PLAU E2F6 E2F7 RANBP1 RRM1 CDKN2C SP1 RRM2 CDK2 DHFR CCNE1 POLA1 CBX5 RYBP ATM MCL1 CEBPA E2F1 CCNE2 TRRAP CDKN2A CDC6 SMARCA2 TK1 HIC1 CANONICAL NF-KAPPAB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CANONICAL NF-KAPPAB PATHWAY Canonical NF-kappaB pathway NFKB1 NFKBIA IKBKG PRKCA CYLD NOD2 ATM CHUK TNFAIP3 BTRC BIRC2 RIPK2 ERC1 TNF UBE2D3 RELA TRAF6 BCL10 TNFRSF1A MALT1 XPO1 IKBKB RAN EPHRIN A REVERSE SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRIN A REVERSE SIGNALING Ephrin A reverse signaling EFNA5 FYN EPHA5 TCR SIGNALING IN NAIVE CD8+ T CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TCR SIGNALING IN NAIVE CD8+ T CELLS TCR signaling in naive CD8+ T cells VAV1 FYN CBL CD3E PLCG1 CARD11 BCL10 MALT1 PDPK1 B2M MAP3K8 PTPRC LCP2 PTPN6 CD8B CD8A PRKCQ AKT1 CD86 CD80 PRF1 CD3G CD3D RASGRP2 RASGRP1 TRAF6 CD28 NRAS CD247 SHC1 PRKCB PRKCE RAP1A IKBKB HRAS HLA-A KRAS IKBKG CSK PRKCA GRAP2 TRPV6 LAT GRB2 SOS1 LCK PAG1 RASSF5 STIM1 ORAI1 ZAP70 CHUK MAP3K14 REGULATION OF TELOMERASE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF TELOMERASE Regulation of Telomerase ZNFX1 HNRNPC YWHAE TGFB1 CCND1 SMG5 CDKN1B IFNAR2 MTOR RPS6KB1 SIN3B SIN3A MYC NFKB1 AKT1 TERF2 MXD1 SAP30 JUN IRF1 NR2F2 FOS IL2 UBE3A HDAC2 IFNG HDAC1 MAX ABL1 RBBP4 SAP18 RBBP7 BLM NBN EGFR SMAD3 XRCC6 XRCC5 ESR1 MRE11A EGF MAPK1 SP1 RAD50 SP3 MAPK3 HUS1 ATM NCL RAD1 RAD9A TERT E2F1 HSP90AA1 PINX1 SMG6 PARP2 TINF2 TERF1 DKC1 POT1 TERF2IP TNKS WRN ACD PTGES3 WT1 REGULATION OF RETINOBLASTOMA PROTEIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RETINOBLASTOMA PROTEIN Regulation of retinoblastoma protein TBP SUV39H1 CCND1 AATF BRD2 MET PAX3 MITF RBP2 ATF7 DNMT1 RB1 CKM ATF2 PPP2R3B CDKN1A CDKN1B SIRT1 MAPK14 TAF1 E2F3 PPARG HDAC3 EP300 E2F2 BGLAP CSF2 MEF2C RUNX2 MAPK9 JUN SFTPD TFDP1 MYOD1 MDM2 CCND3 CEBPB ELF1 CCNA2 HDAC1 CTBP1 TGFB2 SKP2 ABL1 RBBP4 GSC MAPK11 E2F4 RAF1 SMARCB1 CREBBP CDK4 CDK2 PPP2CA CCNE1 CEBPA CEBPD E2F1 SPI1 CBX4 CDKN2A CCND2 SMARCA4 UBTF CDK6 REGULATION OF CYTOPLASMIC AND NUCLEAR SMAD2 3 SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF CYTOPLASMIC AND NUCLEAR SMAD2 3 SIGNALING Regulation of cytoplasmic and nuclear SMAD2 3 signaling CALM3 CALM1 CTDSP1 CALM2 MAPK3 MAP3K1 CTDSP2 PIAS4 SMAD2 KPNA2 NUP214 SMAD4 UBE2I SMAD3 KPNB1 CTDSPL NUP153 PPM1A MAPK1 TRAIL SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TRAIL SIGNALING PATHWAY TRAIL signaling pathway RIPK1 IKBKG FADD TNFRSF10C CFLAR TNFRSF10B TNFRSF10A TNFRSF10D PIK3R1 MAPK8 TNFSF10 MAPK1 DAP3 MAPK3 MAP3K1 PIK3CA TRADD CHUK MAP2K4 SMPD1 TRAF2 PIK3CB IKBKB CASP8 CASP10 REELIN SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REELIN SIGNALING PATHWAY Reelin signaling pathway GRIN2B MAP2K7 NCK2 ARHGEF2 GSK3B FYN LRP8 PIK3R1 CBL RELN MAP3K11 RAPGEF1 MAP1B DAB1 MAPT PAFAH1B1 CDK5R1 CRKL MAPK8 ITGA3 ITGB1 LRPAP1 GRIN2A AKT1 CDK5 PIK3CA VLDLR RAP1A HIF-1-ALPHA TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HIF-1-ALPHA TRANSCRIPTION FACTOR NETWORK HIF-1-alpha transcription factor network EPO CITED2 SLC2A1 HMOX1 PGK1 LDHA NDRG1 ENG SERPINE1 EGLN1 EGLN3 NOS2 GATA2 HNF4A EP300 HIF1A BHLHE40 ITGB2 AKT1 CXCR4 HDAC7 TF ABCG2 ID2 NCOA1 NCOA2 IGFBP1 ARNT JUN BHLHE41 ADM RORA HK2 FOS HK1 GCK CA9 CREB1 PGM1 PKM PLIN2 ALDOA EDN1 ABCB1 PFKFB3 FECH BNIP3 NT5E CP CXCL12 PFKL COPS5 LEP FURIN CREBBP SMAD4 SMAD3 SP1 VEGFA NPM1 MCL1 TERT TFRC ETS1 ENO1 RAPID GLUCOCORTICOID SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RAPID GLUCOCORTICOID SIGNALING Rapid glucocorticoid signaling GNAL CRH GNB1 MAPK14 MAPK11 MAPK8 MAPK9 GNG2 SIGNALING EVENTS MEDIATED BY TCPTP%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY TCPTP Signaling events mediated by TCPTP INS GAB1 PTPN2 PTPN1 INSR KDR LMAN1 PDGFRB RAB4A PIK3R1 GRB2 SOS1 MET STAT6 KPNA2 STAT5B PDGFB CREBBP EGFR KPNB1 STAT5A STAT1 STAT3 EGF ITGB1 VEGFA PIK3CA ATR ITGA1 CSF1R EIF2AK2 CSF1 SHC1 SRC HGF PIK3CB JAK3 PIAS1 JAK1 PAR4-MEDIATED THROMBIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PAR4-MEDIATED THROMBIN SIGNALING EVENTS PAR4-mediated thrombin signaling events F2RL2 PLCB2 F2RL3 RHOA GNG2 F2 GNA13 ROCK1 GNB1 ROCK2 GNA14 GNA15 MYL2 GNAQ GNA11 BMP RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BMP RECEPTOR SIGNALING BMP receptor signaling TAB2 ZFYVE16 CTDSP1 TAB1 PPP1R15A BMPR2 CTDSP2 GSK3B SMAD1 SMURF2 BAMBI SMAD9 XIAP SMAD5 BMP4 NUP214 PPP1CA SMAD4 BMP7 CHRD CHRDL1 CTDSPL SOSTDC1 SMAD7 CER1 SKI PPM1A MAP3K7 AHSG FST NOG MAPK1 HFE2 RGMB SMAD6 BMP6 RGMA GREM1 SMURF1 BMP2 BMPR1B BMPR1A HEDGEHOG%NETPATH%HEDGEHOG Hedgehog SMAD1 CREBBP PTCH1 PTCH2 DYRK1A KIF7 MED6 KIF27 SKI MED23 CDK8 SMO CTNNB1 GAS1 YWHAE DHH SDC2 HHIP IHH ARRB2 NR2E1 GLI1 GLI3 GLI2 MED12 CCNB1 SHH HHAT STK36 SIN3A ADRBK1 RAB23 SUFU BOC SAP18 AKT1 PRKACA CDON MED1 TCR%NETPATH%TCR TCR CD5 CD7 PTPN6 CD247 PIK3AP1 RAN PTPN3 ITSN2 ATF2 CYFIP1 TFRC WIPF1 CBLB SLA2 EPRS ENO2 CRKL GOLGA5 RPS6KA5 UBASH3B DPYSL2 AKT1 TRIM25 HOMER3 ICOSLG PRKCD CD2AP PARD3 PRKCQ PRKD2 PRKD1 SKAP1 EPHA3 SKAP2 SH2D2A TXK PIK3R2 PIK3R1 PTTG1IP BCL10 LY9 LDHB LDHA INPP5D PLCG2 SLAMF6 PLCG1 ICOS PAG1 LYN STAT5A VASP STAT5B EGR1 CREBBP JUN NFATC2 NFATC1 LNPEP CGN PTK2 REL CD28 UNC119 GRB2 GRAP CALM1 ADA ITK MTMR10 GDI2 CLTC CD3G SHB CD3E PTPRH CD3D IKBKB PPP3CB TUBA1A CTLA4 JAK3 MAP4K1 VAV3 DBNL DUSP3 SYK ANXA2 RIPK2 NFAM1 PGAM1 FCRL3 TUBB GAB2 FOS ZDHHC17 LIME1 VAV1 VAV2 ENAH BDH1 RAPGEF1 ARHGEF2 HNRNPH3 ARHGEF7 ARHGEF6 AHCY WAS NEDD9 RELA PAK1 STAT4 FLNB CCT8 MPZL1 GIT2 MAP3K1 STAT1 ELP3 DEF6 ITCH ABI1 CTNNB1 ACTR10 CD86 CD84 CD82 CD80 DGKA SLA ARHGAP35 SIT1 GRAP2 ARHGDIB MAP3K8 G6PD MAP2K1 MAP2K2 CISH DYRK1A DYRK1B ANXA11 PRPF4B LAX1 TUBA4A ACLY DOK1 DOK2 CD8A HGS NCL ELMO1 ADAM9 PKP4 RAF1 STAM2 CARD11 KHDRBS1 TSG101 SHC1 PXN STK39 ITPR1 DTX1 RASGRP2 STK4 RASGRP1 SDCBP RAP1A CASKIN2 ABL1 LPXN BMF ACBD6 KIRREL NFKB1 NFKBIA NR4A1 DIAPH1 DLG1 FER PTPRC PTPRA OGN PI4KA CDK1 MAP3K14 LAT NFKBIB GSK3B DDX3X DDX49 HSP90AB1 WDR1 PTPN22 PIK3C2B CABIN1 PSTPIP1 YWHAQ SNRNP70 ZNF404 ACP1 PGM1 NCK1 CHUK SH2D3C MSL2 YWHAZ DNM2 ERBB2IP ACTA1 ZAP70 PKM CREB1 LCK TRAF6 RASA1 PECAM1 C9orf78 EVL LCP2 SOS1 DOCK2 SOS2 CRK R3HCC1L CEBPB SRC ATP1A3 ATP1A1 CBL FYB MALT1 HDAC7 CDC42 DNAJB1 MAPK9 MUC1 MAPK8 MAPK7 SH3BP2 PTK2B MAPK1 FYN SH2B3 WASF2 MAPK3 TRAT1 TXNRD1 PTPN11 PTPN12 MAPK14 CD2 MAPK11 EIF3M CD4 TEC RPS6KB1 BCR%NETPATH%BCR BCR DBNL SYK CHUK PDPK1 GAB1 RRAS2 FOS GAB2 LIME1 VAV1 VAV2 DNM2 LAT2 CCNA2 HCK ZAP70 RAP2A CREB1 BANK1 LCK RASA1 RAPGEF1 HCLS1 LCP2 SOS1 SOS2 CRK HDAC5 WAS NEDD9 CBL RELA MALT1 HDAC7 MAPK9 MAPK8 SH3BP2 CCL4 CCL3 MAPK1 PTK2B CSK FYN SH2B2 MAPK4 MAPK3 PTPN18 CD72 CMTM3 PLEKHA1 PLEKHA2 STAT1 STAT3 ATP2B4 PTPN11 MAPK14 TEC RPS6KB1 CD5 BAX CTNNB1 FOSB PTPN6 PIK3AP1 FCGR2B BCAR1 RB1 ATF2 IFITM1 CD81 CBLB SLA2 ELK1 CRKL CCND3 TCL1A CCND2 RPS6KA1 AKT1 PIP4K2A PIP4K2B PIP4K2C JUNB MAP3K7 GTF2I MAP2K1 MAP2K2 PRKCB PRKCE PRKCD RPS6 DOK1 DOK3 CCNE1 MAPKAPK2 BTK PRKCQ PRKD1 RAF1 CARD11 BLK SHC1 ITPR1 ITPR2 DAPP1 PIK3R2 PIK3R1 BCL10 FOXO3 FOXO1 RASGRP3 CD79B CD79A BCL2L11 CD19 INPP5D BTLA CHST15 PLCG2 EIF4EBP1 STAP1 PIP5K1A PIP5K1B PLCG1 PIP5K1C LYN VASP JUN NFATC3 NFATC2 BRAF PTK2 NFKB1 NFKBIA CDK7 HNRNPK CDK6 PTPRC BCL6 CDK4 CDK2 BCL2 REL CYCS GRB2 CD22 GSK3B ITK GSK3A PIK3CD PIK3CG IKBKB CASP9 CASP7 CASP3 BLNK IKBKG NCK1 MAP4K1 CR2 IL1%NETPATH%IL1 IL1 NFKBIA TOLLIP UBE2N REL TAB3 TAB2 TAB1 MAP3K14 MYD88 NFKBIB RB1 ATF2 GSK3B IL1RN IRS1 HSPB2 IL1RAP IKBKAP ECSIT IKBKB PPP6C SIRPA AKT1 IKBKG MAP3K7 MAP2K3 MAP2K4 MAP2K1 MAP2K2 FBXW5 CHUK IL1R1 IL1R2 PLA2G4A IRAK3 IRAK4 IL1A DOK1 TRAF6 IL1B PELI1 UBE2V1 SQSTM1 PELI2 PIK3R2 PIK3R1 PRKCZ RELA MAPK9 ACAN MAPK8 IRAK1 IRAK2 MAPK1 PLCG1 MAP2K7 MAPK3 MAP2K6 MAP3K2 MAP3K3 JUN STAT3 EIF2AK3 PTPN11 MAPK14 S100B EIF2S1 NFKB1 SOD1 IL2%NETPATH%IL2 IL2 SOCS1 TERT MKNK1 STAT4 EIF4EBP1 PTK2B MAPK1 FYN EIF4E MAPK3 STAT5A LYN STAT5B JUN BAD STAT1 STAT3 PTPN11 NMI STAM MAPK14 IL2 NFKB1 MTOR VIL1 RPS6KB1 IL2RA CDK2 IL2RB BCL2 PTPN6 GRB2 ITM2B EIF3B ATF2 IRS1 PIK3CD IRS2 YBX1 PIK3CB SHB NR3C1 ETS1 ELK1 ETS2 PIK3CG CRKL AKT1 JAK2 JAK3 JAK1 HSP90AA1 MAP2K1 MAP2K2 CISH SYK IL15 RPS6 GAB2 VAV1 CREB1 PIK3CA CCNE1 LCK SOS1 RAF1 PLCB1 SGK1 STAM2 CRK SHC1 PIK3R3 PIK3R2 PIK3R1 CBL FOXO3 IL2RG PRKCZ RELA SOCS3 MAPK8 IL3%NETPATH%IL3 IL3 CSF2RB PIK3R2 PIK3R1 GATA2 CBL FOXO3 GATA1 FOXO1 PPP2CA SOCS2 SOCS3 PAK1 MAPK8 RXRA BCL2L11 INPP5D MAPK1 FYN MAPK3 LYN STAT5A STAT5B BAD KCNIP3 STAT3 PILRB PTPN11 MAPK14 PTK2 GNB2L1 NFKB1 IL3 TEC PTPRC FES BCL2 BAX PTPN6 GRB2 BCL2L1 ATF1 RB1 ATF2 GSK3B GSK3A YWHAB SLC2A1 PIK3CD HSPB1 CRKL PPP3CA YWHAQ AKT1 JAK2 PRKACA HRAS JAK1 MAP2K1 FCER1G CISH SYK PRKCB GAB1 PRKCA TYK2 GAB2 YWHAZ DNM1 VAV1 HCK DOK1 DOK2 CREB1 LCK IL3RA RARA RAPGEF1 RAF1 SOS1 CRK VCL SRC SHC1 PXN IL4%NETPATH%IL4 IL4 CREBBP BAD STAT1 STAT3 PTPN11 STAM MAPK14 PTK2 NFKB1 NFKBIA IL4 MAPK11 RPS6KB1 FES HIST3H3 PTPN6 GRB2 BCL2L1 ATF2 CD40 SPI1 IRS1 PIK3CD IRS2 ELK1 ETS1 IKBKB EP300 AKT1 JAK2 JAK3 JAK1 IL13RA1 IL4R SYK CHUK NCOA3 IL13 PRKCD TYK2 GAB2 SND1 DOK2 PIK3CA LCK RASA1 BTK SOS1 HIST2H3C CEBPA CEBPB SHC1 CXCR4 PIK3R2 PIK3R1 CBL IL2RG PRKCZ RELA SOCS3 MAPK8 SOCS1 ADRBK2 INPP5D PLCG2 MAPK1 FYN STAT6 PLCG1 SOCS5 MAPK3 STAT5A STAT5B IL5%NETPATH%IL5 IL5 GSK3B ATF2 GSK3A IL5RA ELK1 PIK3CG CRKL RPS6KA1 AKT1 JAK2 HRAS SOX4 JAK1 MAP2K2 SYK PRKCB PRKCD PLA2G4A YWHAZ VAV1 DNM2 HCK RAPGEF1 BTK HCLS1 RAF1 SOS1 SHC2 SHC1 CSF2RB PIK3R2 PIK3R1 CBL FOXO3 SDCBP SOCS1 ALOX5 MAPK1 PTK2B SH2B2 MAPK3 LYN STAT5A STAT5B JUN STAT1 STAT3 PTPN11 MAPK14 GNB2L1 NFKB1 NFKBIA IL5 IL2RB CTNNB1 UNC119 BAX PTPN6 GRB2 IL6%NETPATH%IL6 IL6 PIK3R2 FOXO4 PIK3R1 CBL FOXO3 NLK FOXO1 SOCS3 MAPK8 ERBB3 INPP5D ERBB2 EIF4EBP1 PTK2B MAPK1 FYN PLCG1 HNRNPA1 EIF4E MAP2K6 MAPK3 LYN STAT5A STAT5B CREBBP JUN STAT1 BAD STAT3 PTPN11 MAPK14 BMX PTK2 NFKB1 CDK9 NFKBIA IL6 TEC CDK5 RPS6KB1 FES GRB2 RB1 GSK3B CD40 INPPL1 HSPB1 RPS6KA2 SIRPA EP300 AKT1 RAC1 JAK2 HRAS IL6R MAP3K7 MAP3K4 EIF2A JAK1 NCOA1 MAP2K4 PIAS3 HSP90AA1 DAXX MAP2K1 MAP2K2 PRKCD GAB1 TYK2 HNF1A FOS GAB2 VAV1 FGR HCK AR BTK MAPT IL6ST SOS1 SGK1 CEBPB HDAC1 SHC1 PXN IL-7%NETPATH%IL-7 IL-7 GSK3B GSK3A SHC1 IRS1 CLTC CBLB IRS2 PIK3R1 FOXO3 IL2RG FOXO1 AKT1 MAPK1 PTK2B FYN JAK3 MAPK3 JAK1 STAT5A STAT5B MAP2K1 MAP2K2 BAD STAT1 STAT3 STAM IL7 IL7R ALPHA6BETA4INTEGRIN%NETPATH%ALPHA6BETA4INTEGRIN Alpha6Beta4Integrin FYN SFN EIF4E MAPK3 SMAD2 JUN YES1 SMAD3 LAMB3 BAD LAMB2 LAMB1 PTPN11 MAPK14 PTK2 MTOR EIF6 GRB2 VIM TP73 YWHAE RTKN IRS1 YWHAB ITGB4 PIK3CD LAMC2 IRS2 PIK3CB LAMC1 MYLK3 PIK3CG YWHAQ CASP3 AKT1 RAC1 EPHB2 YWHAH DSP DST PRKCD GAB1 RPSA PRKCA FOS YWHAZ RHOA ERBB2IP AR PIK3CA ITGA6 MET PLEC COL17A1 LAMA5 CD151 LAMA2 SHC1 LAMA1 SRC LAMA3 PIK3R3 PIK3R2 MST1R PIK3R1 NTN1 EGFR PAK1 ERBB2 EIF4EBP1 CLCA2 ABL1 MAPK1 CLCA1 IL9%NETPATH%IL9 IL9 STAT3 IRS2 PTPN11 TYK2 PIK3R1 IL2RG KAT5 IL9 MAPK1 AKT1 GRB2 STAT6 JAK3 IL9R MAPK3 JAK1 STAT5A STAT5B VCP MAP2K1 MAP2K2 SHC1 IRS1 STAT1 RANKL%NETPATH%RANKL RANKL TNFRSF11A PIK3R1 FOXO4 CBL RELA EGFR RELB MAPK9 MAPK8 ABL1 PLCG2 EIF4EBP1 MAPK1 FYN PLCG1 MAP2K7 MAPK3 MAP2K6 LYN HSPA8 JUN HSPA5 BAD STAT1 NFATC1 PILRA MAPK14 PTK2 MTOR NFKB1 NFKB2 SMARCA4 NFKBIA CYLD RPS6KB1 RPS6KB2 REL TAB2 PTPN6 TAB1 ATF2 SPI1 FHL2 CBLB TREM2 SIRPB1 FCAR IKBKB FCGR3A FCGR3B AKT2 TNFSF11 AKT1 MAP3K8 IKBKG CAPN1 ATP6V1E1 MAP3K7 JAK1 VAV3 HSP90AA1 MAP2K1 SYK CHUK TRAF2 MITF TRAF1 GAB2 ETV5 OSCAR RUNX1 TYROBP CREB1 TRAF3 TRAF6 TRAF5 SQSTM1 PRKAA1 CEBPB PRKAA2 PSMD14 SRC PIK3R2 TNFRSF11B LEPTIN%NETPATH%LEPTIN Leptin ATF1 ATF2 IRS1 IRS4 IRS2 ELK1 IGF1R RPS6KA2 CFL2 RPS6KA1 LEPR AKT1 EP300 PDIA3 MAP2K3 PRKAB2 MAP2K1 MAP2K2 CISH CSNK2A1 PRKCE RPS6 PRKCD PRKAB1 RUNX2 MAPKAPK2 RAF1 KHDRBS1 SHC1 PIK3R2 PIK3R1 PRKCZ ACACB FOXO1 ACACA SOCS2 SOCS3 PLCG2 EIF4EBP1 PLCG1 SOCS7 MAP2K6 STAT5A STAT5B ESR1 PTK2 NFKB1 NFKBIA CDK5 SP1 GNAQ SP3 REL PDE3A GRB2 GSK3B GSK3A ITGB5 PTEN HSPB2 HSPB1 SLC2A4 IKBKB IKBKG JAK2 JAK3 JAK1 NCOA1 CHUK GAP43 MMP14 CREB1 LCK MAPT CD44 CRP PRKAA1 PRKAA2 SRC EGFR RELA MAPK8 ERBB2 MAPK1 FYN EIF4E SH2B1 MAPK3 BAD NOS3 STAT1 LIMK1 STAT3 PTPN11 MAPK14 MTOR RPS6KB1 LEP TSH%NETPATH%TSH TSH GNAI2 GNA13 SOCS3 SOCS1 GNA11 GNA12 EIF4EBP1 MAPK1 CGA RALGDS MAPK3 MAP2K6 VASP HSPA8 SLC16A1 HSPA5 STAT1 KCNIP3 STAT3 MAPK14 TSHR PTK2 MTOR NFKBIA GNAO1 TG RPS6KB1 CDK4 GNAQ APEX1 LEP CDK2 PPP1R1B GNAS CALR NFKBIB RB1 ATF2 ARF1 CDKN1B SLC2A1 IRS2 IGF1R IKBKB CCND3 BSG RPS6KA1 AKT1 PRKACA HMGN2 JAK2 HRAS TSHB JAK1 CTSB HMGN1 MAP2K3 MAP2K1 ANXA1 PDPK1 PDE4D RPS6 PRKCA SCRIB RHOA CREB1 PIK3CA CCNE1 AKT1S1 CANX RAF1 SRC SHC1 GNAI3 CREM PIK3R2 PIK3R1 ATP1A1 PRKCZ RAP1GAP RELA GNAI1 TSLP%NETPATH%TSLP TSLP CIC RBM7 GPSM3 JAK1 CDV3 HSP90AA1 WDR36 PPP1R12A FCER1G DBNL NCOA3 ATRX CAD SEPT1 NAV1 GAB2 ETV3 SEPT2 SUPT3H WDR33 RNF168 HCK MED24 PIK3CA LCK PABPC1 LCP1 DOCK2 PLEC HEMGN KDM3B SRC WIZ ADD3 RELA ADD1 RELB MAPK9 MAPK8 PUF60 LMNA FAM120A STAT4 MAPK1 FAM63A FYN STAT6 PDLIM5 EIF4E SRSF11 BRD4 CLASP2 MAPK3 PTPN18 STAT1 SEMA4B STAT3 PTPN11 MAPK14 TPD52L2 GATAD2B MAPK12 MAPK10 TEC SERBP1 RLIM NCAPD2 PTPN6 PTPN7 CRLF2 ITSN2 RPL4 ATF2 MDC1 CD84 CRTC2 OXTR PHLDB1 TMEM41B WIPF1 PANK1 CTNND1 INPPL1 ICAM2 CASC5 MKI67 EPRS RPL7 STK10 MPRIP STMN1 CHEK1 AKT1 JUNB SRRM2 MAP2K1 MAP2K2 SP110 RPS6 LARP4B THOC5 TEX2 HCFC1 DOK2 PSPC1 MADD BTK ATF7 TAGLN2 TAGLN3 TLN1 OPTN SKAP2 TMEM63A SHC1 BOD1L1 DAPP1 CDCA8 CSF2RB ZC3HAV1 FOXO3 RPAP1 CAMSAP1 MTDH ARHGAP21 EIF4EBP1 C9orf129 LYN STAT5A VASP STAT5B YES1 TSLP NUP153 PUM1 TJAP1 NFKB1 ZZEF1 NFKB2 NFKBIA FES UBE2O RPS20 CALM3 PIN4 IL7R CALM1 CALM2 DIDO1 DOCK5 AHCTF1 MTMR10 NUMA1 PPP1R11 ITGB3 CHD8 LMNB1 IRF2BPL AKAP13 LRRFIP1 NELFA LDLRAP1 JAK2 FSH%NETPATH%FSH FSH MAPK1 AKT1 FYN PRKACA CGA APPL1 MAPK3 TGM2 MAP2K1 MAP2K2 FSHB RPS6 TSC2 MAPK14 MTOR CREB1 PRKAR1A FSHR HIST3H3 MDM2 RARA RAF1 SGK1 PLCD1 PTPRR PRKAA2 SRC HSPB1 ARRB1 ARRB2 ARR3 FOXO3 EGFR FOXO1 RELA RPS6KA3 GJA1 YWHAQ GRK4 ADRBK1 AKT2 GRK6 EIF4EBP1 ABL1 ANDROGENRECEPTOR%NETPATH%ANDROGENRECEPTOR AndrogenReceptor AR PPP1R14A CREB1 HDAC1 HSPB1 AKT1 PIK3R1 PTK2 NOTCH%NETPATH%NOTCH Notch DLL1 RELA DLL3 APH1A DLL4 NCSTN APH1B BLOC1S1 MAPK1 HES1 HES5 MAPK3 JAG2 SPEN SMAD1 JAG1 SMAD3 STAT3 WDR12 NFKB1 ITCH SNW1 CNTN1 TCF3 APP GSK3B MAML2 MAML1 FHL1 RBPJ YY1 LFNG SIN3A POFUT1 HEY2 MAGEA1 AKT1 EP300 CIR1 SKP2 JAK2 SKP1 PSENEN HES6 MEF2C RING1 FBXW7 ADAM10 RBX1 SAP30 NCOR2 KAT2B ADAM17 NCOR1 NOV LCK MFNG NUMB MAML3 NOTCH2 NOTCH3 HDAC2 NUMBL NOTCH1 SRC HDAC1 NOTCH4 LEF1 PSEN2 CUL1 DTX1 FURIN PIK3R2 PIK3R1 PSEN1 ASCL1 EGFR1%NETPATH%EGFR1 EGFR1 ATF1 ITSN2 USP6NL RPL30 TFRC ARAF ATP5C1 HNRNPR ENO1 ELK1 EPS8 ELK4 GJA1 MPRIP TFG UBASH3B MYC AKT1 PLCE1 ANKS1A PRKCG PRKCI PRKCB PRKCD SCRIB PRKCA FRS2 FRS3 SCAMP3 KIAA1217 ZFYVE16 PRKAR1A SDPR PARD3 MT-CO2 PRKD1 RBCK1 CTBP1 IQGAP1 PRKCZ SLC5A5 LDHA MYO6 PLCG2 PLCG1 S100A14 S100A11 S100A10 LYN JUN AFAP1L2 JUND JUP BRAF CYLD TOLLIP TRIP6 PYGB ARF4 RPLP0 CLTC CLTA SHB ARHGAP5 ENSA PLEKHN1 JAK2 APPL2 JAK1 APPL1 SERPINB3 ANXA1 ANXA2 DUSP1 PGAM1 ANXA4 EPS15L1 FOS DYNLL1 PLSCR1 GPRC5A TKT PHLPP1 AHNAK HTT RPS27L SNX33 EGFR ADRBK1 AP2S1 STX4 RICTOR FLNB RPS2 LDLR GSN STAT1 STAT2 MCF2 STAT3 HIPK3 HIPK2 DCBLD2 ABI1 PKN2 FRK CDKN3 CTNND1 IRS2 LAPTM4A C11orf52 STK11 CDH3 CYSRT1 GRB14 CDH2 CDH1 CFL1 GRB10 TOM1 MAP3K4 MAGI1 MAP2K3 PIAS3 MAP2K1 MAP2K2 DYRK1A DYRK1B PRPF4B TOM1L1 TOM1L2 HAT1 PKP2 ADAM9 PKP4 PKP3 STAMBP PHPT1 PHLDB2 COL17A1 KHDRBS1 SHC1 FOXO4 FOXO1 STIP1 SOCS3 ATXN2 RAP1A SOCS1 HNRNPDL EIF4EBP1 ABL1 ABL2 MAP2K7 SLC38A2 MAP2K5 KIRREL TNK2 GAREM RFXANK NFKB1 PTPRE DAB2 CDK5 PTPRA SP1 CDK2 ALB BCL2 CDK1 MAP3K14 RAB5A EIF4G1 ITGB1 BCAR3 ITGB4 CALCOCO2 PTEN PIK3CD PIK3CB PTPN23 PIK3CG PIK3C2B NCK2 ACP1 CCDC50 NCK1 ACTR3 DSP ACTR2 PDCD6IP PPP1R12A KSR1 ITGA3 SH2D3C ERBB2IP PKM PIK3CA LCK DSG2 SOS1 CRK SOS2 MET SLC25A6 CEBPA PRKAA1 CEBPB PRKAA2 SRC WBP2 HDAC1 ITLN2 SRI CDC42 SLITRK6 FYN CSK RBBP7 HNRNPA1 CTNNAL1 SH2B1 PTPN1 PTPN18 PPP1R14B PTPN11 PTPN12 BAIAP2 MTOR PTPN6 PTPN5 PVRL1 BCAR1 SPG20 ERRFI1 APP AHCYL1 PITPNA ZDHHC5 CBLC CBLB ANTXR1 ACTB CRKL RPS6KA3 BAIAP2L1 RPS6KA5 SNRPD2 TRIM29 RPS6KA2 RPS6KA1 EPHB2 TNS4 TNS3 RPS10 EPHB1 SLC12A7 EPHB4 TNS2 TNS1 EPHB3 EPHA4 ACTN1 KRT8 KRT7 KRT5 ACTN4 TAGLN2 TLN1 RIN1 PFN1 EPHA1 TP53 EPHA2 GRB7 SDC4 STXBP1 SH2D2A SDC3 PIK3R3 PIK3R2 PIK3R1 PTTG1IP MYL12B RACGAP1 RALGDS SNX5 STAT5A VASP STAT5B INSR SIAH2 SIAH1 PTK6 STAM PTK2 SMU1 WNK1 SDC1 CALM3 GRB2 CALM1 CALM2 CC2D1A PTPRR HIP1 SH3KBP1 AP2A1 PTPRK WASL LIMD1 PTPRF OTUD6B RAC1 HRAS GIT1 VAV3 MAP4K1 CDV3 NCOA3 MINK1 GAB1 TYK2 GAB2 IL17RD VAV1 RHOA VAV2 CEACAM1 CTTN KIT ARHGEF4 ALDOA ARHGEF7 ARHGEF5 CSTB NEDD9 PRKX RELA PAK1 SH3BGRL PDZD11 CD59 MAP4K5 EPS15 MPZL1 MAP3K2 MAP3K3 GIT2 MAP3K1 HUWE1 PLEKHA5 PLEKHA6 AP2B1 ITCH KRT18 KRT17 AXL NEDD4 EPPK1 ESYT1 TJP2 SH3GL3 NDUFA13 INPPL1 PEBP1 ARHGAP35 ARHGAP42 SIRPA PTRF SH3GL2 KRT6A PDGFRB RALBP1 APLP2 EEF1A1 DOK1 DOK2 ADAM17 HGS EEF1A2 ELMO2 RAF1 STAM2 VCL DDX6 PXN DAPP1 PLD1 LPP PLD2 EFNB2 SDCBP UBB CALD1 CASKIN2 RIPK1 SMAD2 SMAD3 HSPA4 CAV2 CAV1 CRIM1 ARHGAP32 DLG3 GSK3B DYRK4 DYRK3 GSK3A DOCK4 DDX3X USP31 YWHAB RBM3 CASP9 FLOT1 FLOT2 TGIF1 KLF11 PDPK1 LSR ARAP1 YWHAZ EPN1 DNM1 EPN2 EPN3 ACTA2 SFPQ CREB1 ELF3 RASA1 MYH9 DOCK1 PLEC RALA RALB MVP RGS16 CAMK2A ASAP3 ASAP1 ATP1A1 CBL PDLIM1 MAPK9 MAPK8 MAPK7 MARVELD2 ERBB3 ERBB2 REPS2 MAPK1 PTK2B MTA2 PDLIM4 MAPK3 REPS1 SNCA BAD NOS3 EGF SPRY4 PPP2R3A MAPK14 HSPE1 TNIP1 RPS6KB1 HIST3H3 SPRY3 SPRY2 SPRY1 KRAS VIM ZPR1 ID%NETPATH%ID ID ID2 MYOD1 ID1 CDK2 ID4 MYF6 ID3 TCF4 TCF3 RAF1 ATF3 MYF5 RB1 FHL2 ELK1 ETS2 ELK3 ELK4 IFI16 PSMD4 MAPK1 HES1 MAPK3 MYOG TCF7L2 SREBF1 MAP2K1 MAP2K2 SMAD3 SMURF2 TCF12 OLIG1 OLIG2 PAX5 PAX2 RBL2 RBL1 PAX8 KITRECEPTOR%NETPATH%KITRECEPTOR KitReceptor ATF2 WIPF1 CBLB ELK1 CRKL RPS6KA1 GRB10 EP300 AKT1 MAP2K1 MAP2K2 PRKCB RPS6 MATK PRKCA MITF DOK1 DOK2 DOK3 BTK EZR RAF1 SKAP2 GRB7 SHC1 PIK3R2 CSF2RB PIK3R1 FOXO3 SOCS1 INPP5D G3BP1 PLCG2 EIF4EBP1 ABL1 STAP1 PLCG1 SOCS6 MPDZ SOCS4 SOCS5 LYN STAT5A STAT5B JUN YES1 RDX NFATC2 MSN TNFRSF10A FER FES CDK2 GRB2 GRAP IL7R LAT PTPRU GSK3B GSK3A SH3KBP1 CLTC GYS1 SPRED2 SPRED1 JAK2 JAK3 HRAS ACTR2 GAB2 VAV1 FGR HCK PIK3CA RASA1 KIT SOS1 CRK RAB7A SRC WAS CBL RELA FYB PAK1 MAPK8 MAPK1 FYN SH2B3 SH2B2 MAPK3 BAD STAT1 STAT3 PTPN11 MAPK14 MAPK12 EPOR MTOR KITLG TEC RPS6KB1 PTPN6 MAD2L1 TGF_BETA_RECEPTOR%NETPATH%TGF_BETA_RECEPTOR TGF_beta_Receptor RB1 ATF2 SPARC ZFYVE9 PPP2R2A HOXA9 RPS6KA5 CDC23 PPP2R1A MYC CDC27 AKT1 SOX9 BTRC JUNB RNF111 VPS39 PDK1 SKP1 NUP214 MEF2A MEF2C DAXX FOXH1 RUNX3 RUNX2 RUNX1 AR EID2 ZFYVE16 PRKAR1B EWSR1 PARD3 SIK1 TP53 ATF3 SDC2 FOXG1 NEDD4L PIK3R2 PIK3R1 ANAPC10 SNX4 SNX1 SNX2 PRKAR2A SPTBN1 SNX6 TRAP1 WWTR1 CREBBP JUN JUND STK11IP IRF2BP1 PTK2 SNW1 GIPC1 CDC16 GRB2 DCP1A TP73 ACVRL1 CDKN1A CITED1 BRCA1 CTCF MED15 IKBKB ING2 XPO1 XPO4 HNF4A MAP4K1 NCOA1 FOS RHOA UCHL5 NME1 KAT2B ZEB2 ZEB1 STRAP CD44 ENG YAP1 PPP2CA STAMBPL1 CTNNA1 CTNNA2 DYNC1I1 SAMD3 NFYA NFYB NFYC WWP1 AP2B1 FKBP1A SKI ITCH CTNNB1 FOSB UBE2D2 UBE2D3 UBE2D1 ETS1 PPP1CC STK11 FNTA CCND1 EP300 SNIP1 MAP3K7 MAP2K3 MAP2K1 MAP2K2 ANAPC7 CDC25A PIAS2 RBX1 PIAS1 CCNE1 HGS ANAPC4 ANAPC5 RAF1 ANAPC1 CSNK1G2 KPNB1 ANAPC2 DDX5 SHC1 PXN CUL1 FOXO4 FOXO3 FOXO1 CCNB2 DVL1 EIF4EBP1 SKIL MAP2K6 SMAD2 HSPA8 SMAD4 TGFB2 UBE2I SMAD3 TGFB1 SMURF2 VDR SMURF1 TGFB3 CAV1 NUP153 SMAD6 ESR1 NFKB1 SMAD7 NFKBIA DAB2 CDK6 COPS5 CDK4 SP1 CDK2 CDK1 TCF4 DYNLRB2 DYNLRB1 TAB1 ITGB1 GSK3B ITGB3 ARRB2 SUMO1 TGIF1 KLF10 CHUK PDPK1 AXIN1 OLIG1 AXIN2 TGFBR1 TGFBR2 PJA1 ERBB2IP RBL2 TGFBR3 PPM1A TFDP1 RBL1 TFDP2 PIK3CA TRAF6 SOS1 CRK CAMK2B PPP1R15A CAMK2D ROCK1 HDAC1 SRC LEF1 CAMK2A MAPK8 FZR1 PARD6A MAPK1 E2F4 E2F5 CAMK2G MAPK3 MAPK14 MTOR PML RPS6KB1 EIF3I BCAR1 TRIM33 WNT%NETPATH%WNT Wnt DIXDC1 FZD10 FRAT1 FRAT2 SOX1 CCND1 CDH2 CDH1 AKT1 BTRC PRKACA MAP3K7 MAP3K4 PRKCG MAP2K4 PRKCH WNT5B PRKCB PRKCE WNT5A PRKCD PRKCA CSNK1D CSNK1E DKK1 SFRP4 SFRP1 SFRP2 DAAM1 PRKCQ ROR1 ROR2 RAF1 PI4K2A CTBP2 CTBP1 CHRNA7 NLK WNT6 SLC9A3R1 DVL1 DVL2 DVL3 PIP5K1B WNT1 WNT2 WNT3 MARK2 WNT4 FZD1 SMAD1 KL FZD3 JUN GCKR YES1 FZD2 JUP SETDB1 FZD5 WNT3A FZD4 FZD7 FZD6 FZD9 FZD8 NFATC2 BCL9 DAB2 CDK6 PPP1R1B PIN1 TCF4 TCF3 GSK3B GSK3A YWHAB CHD7 ILK ARRB1 ARRB2 RSPO2 RSPO3 RSPO1 RAC1 MESDC2 AXIN1 WNT9B KREMEN1 AXIN2 WNT9A RHOA PAX2 ARHGEF4 PPARG LRP1 SRC LEF1 LRP5 LRP6 PPP2CA MAPK8 WNT11 WIF1 FRZB GPC3 MAPK1 MAPK3 TCF7L2 MAP3K1 CSNK1A1 RYK WNT7B WNT7A PPP1CA APC RPS6KB2 CTNNB1 TNFALPHA%NETPATH%TNFALPHA TNFalpha MTIF2 NR2C2 HDAC6 MAPK9 MAPK8 ERBB3 ERBB2 TIFA MAPK1 ROMO1 POLR2H RFFL MAPK3 POLR2L SMARCE1 SPAG9 RNF25 PTPN11 CFLAR MAPK14 MTOR PML RPS6KB1 PRC1 TNIP2 GLB1 HIST3H3 BAX TBKBP1 PDCD2 TRIM32 RPL4 RB1 RPL30 SMARCB1 RPL8 DCAF7 RPL6 MYLK PSMD6 RPS6KA5 PSMD7 TBK1 PSMD2 AKT2 PSMD3 DPF2 AKT1 PSMD1 BTRC RPS11 JUNB GLUL RPS13 PDK1 SKP1 SMARCC1 SMARCC2 CSNK2A1 PRKCE PRKCD PRKCA CDC34 MYL2 KCNQ1 CDC37 TXNIP PRKCQ TRIB3 MYL9 TP53 PIK3R2 PIK3R1 TXN IQGAP2 PRKCZ GLG1 FADD STAT5A TRAP1 CREBBP JUN CRADD PTK2 SMARCA4 REL GRB2 FAF1 OTUD7B IKBKAP PYGL SMPD3 IKBKB CASP10 NKIRAS1 NKIRAS2 RFK IKBKG IKBKE MAP4K2 SYK RIPK3 ACTL6A GAB1 COMMD1 TAX1BP1 ARHGEF1 ARHGEF2 CRYAB AKAP8 XIAP TANK RELA EGFR RELB PAK1 RXRA PSMB5 FLNA BID MAP3K2 MAP3K3 MAP3K1 STAT1 LRPPRC KTN1 ITCH PSMC3 PSMC1 PSMC2 PKN1 HSPA1A CCNT1 IRS1 UBE2D2 ZFAND5 UBE2D3 IRS2 TNF FBL CFL1 KPNA6 PAPOLA EP300 TNFRSF8 MAP3K8 KPNA2 MAP3K7 KPNA3 GTF2I MAP3K5 PIAS3 MAP2K4 MAP2K1 UNC5CL FBXW7 FBXW11 USP2 CYBA TRPC4AP TRAIP DOK1 TXLNA FANCD2 MADD MAPKAPK2 NUPR1 FKBP5 NSMAF COPB2 PSMD12 PSMD13 DIABLO CUL1 RASAL2 TNFRSF11A FOXO1 BAG4 BRINP1 NLRP4 G3BP2 RIPK1 MAP2K7 MAP2K5 MARK2 MAP2K6 SMAD2 HSPA8 ZBTB17 UBE2I SMAD3 HSPA5 SEC16A CAV1 TRAPPC9 MCC GNB2L1 NFKB1 NFKB2 NFKBIA CDK9 COPS3 IRAK1BP1 COPS5 CDK5 BCL3 TAB3 ALPL TAB2 TAB1 NFKBIE MAP3K14 MAP3K11 NFKBIB BCL2L1 YWHAE RNF11 DDX3X HSP90AB1 MCM7 YWHAB TRADD TNFAIP3 HSPB1 HMGB1 CASP9 PPP6C CASP7 CASP8 SUMO1 YWHAQ BCL7A PPP1R13L CASP3 NFKBIZ CASP2 YWHAG YWHAH HSP90AA1 PPP1R12A APAF1 PEG3 CHUK EED TRAF2 TRAF1 TNFRSF1B YWHAZ TNFRSF1A TRAF7 CREB1 TRAF4 RASA3 POLR1A TRAF3 TRAF6 POLR1B POLR1C TRAF5 POLR1D POLR1E PFDN2 MCM5 SOS1 SOS2 BIRC2 BIRC3 HDAC2 SRC HDAC1 USP11 5-ARACHIDONYLGLYCEROL_BIOSYNTHESIS%PANTHER PATHWAY%P05726 5-arachidonylglycerol_biosynthesis PLA1A PLCB3 DAGLA LIPH LPL PLCB1 PLCB2 5HT1 TYPE RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04373 5HT1 type receptor mediated signaling pathway GNB1 GNB4 GNB3 VAMP1 GNB5 VAMP2 KCNK3 VAMP3 SNAP25 KCNK9 SNAP23 GNAI3 PRKX ADCY2 ADCY7 GNAI1 GNAI2 SLC6A4 GNG10 GNG3 GNG2 GNGT2 GNG5 PRKAR2B GNG4 PRKACG PRKAR2A GNG7 GNG8 STX3 PRKACA SNAP29 PRKACB HTR1E HTR1F HTR1D HTR1A HTR1B GNG12 GNG11 GNAO1 GNB2 5HT2 TYPE RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04374 5HT2 type receptor mediated signaling pathway PRKCQ GNB5 PLCB1 PLCD4 PLCB2 PLCD1 KCNK3 KCNK9 HTR2B HTR2C HTR2A PRKCZ SLC6A4 GNA14 GNG10 GNG3 GNG2 GNGT2 PLCZ1 GNG5 GNG4 GNG7 GNA11 PLCG2 PLCE1 GNG8 PLCG1 SLC18A1 SLC18A2 PRKCG PRKCI PRKCH PRKCB PLCL1 PRKCE PRKCD PRKCA GNG12 GNG11 PLCB3 PLCB4 GNB2 GNAQ GNB1 GNB4 GNB3 5HT3 TYPE RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04375 5HT3 type receptor mediated signaling pathway STX3 SLC18A1 SNAP29 VAMP2 KCNK3 SLC18A2 VAMP3 SNAP25 KCNK9 SNAP23 SLC6A4 VAMP8 VAMP1 5HT4 TYPE RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04376 5HT4 type receptor mediated signaling pathway ADCY7 SLC6A4 GNG10 GNG3 GNG2 GNGT2 GNG5 GNG4 GNG7 GNG8 STX3 SLC18A1 SNAP29 SLC18A2 GNG12 VAMP8 GNAL GNB2 GNB1 GNB4 GNB3 VAMP1 GNB5 VAMP2 KCNK3 VAMP3 SNAP25 KCNK9 SNAP23 ADCY2 HTR4 5-HYDROXYTRYPTAMINE BIOSYNTHESIS%PANTHER PATHWAY%P04371 5-Hydroxytryptamine biosynthesis TPH2 DDC TPH1 5-HYDROXYTRYPTAMINE DEGREDATION%PANTHER PATHWAY%P04372 5-Hydroxytryptamine degredation IL4I1 ALDH1A3 ALDH3A1 ALDH1B1 ALDH2 ALDH1A2 ALDH1A1 ALDH16A1 ALDH8A1 ALDH7A1 ALDH9A1 ALDH1L1 MAOB MAOA ALDH1L2 ALDH4A1 ALDH3A2 ALDH3B2 ACETATE UTILIZATION%PANTHER PATHWAY%P02722 Acetate utilization ACSS3 ACSS2 ACSS1 ACTIVINBETASIGNALING_PATHWAY%PANTHER PATHWAY%P06210 Activinbetasignaling_pathway ADENINE AND HYPOXANTHINE SALVAGE PATHWAY%PANTHER PATHWAY%P02723 Adenine and hypoxanthine salvage pathway XDH PRTFDC1 ADA APRT PNP HPRT1 ADRENALINE AND NORADRENALINE BIOSYNTHESIS%PANTHER PATHWAY%P00001 Adrenaline and noradrenaline biosynthesis SNAP29 SLC18A2 VTI1B SLC6A19 SLC6A18 SLC6A17 SLC6A16 SLC6A15 STX7 INMT TH VAMP1 VAMP2 PNMT SNAP25 STX12 DDC NNMT MAOB MAOA SNAP23 DBH SLC6A20 COMT SLC6A2 SLC6A3 SLC18A1 ALANINE BIOSYNTHESIS%PANTHER PATHWAY%P02724 Alanine biosynthesis BCAT1 BCAT2 ALLANTOIN DEGRADATION%PANTHER PATHWAY%P02725 Allantoin degradation ALP23B_SIGNALING_PATHWAY%PANTHER PATHWAY%P06209 ALP23B_signaling_pathway ALPHA ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00002 Alpha adrenergic receptor signaling pathway PLCB3 PLCB4 GNA11 STX6 PLCE1 VAMP1 PLCB1 PLCB2 VAMP2 VAMP3 PRKCG SNAP25 PRKCE PRKCD SNAP23 ITPR1 PRKCA ADRA1B ADRA2C ADRA1A ADRA2A STX10 ALZHEIMER DISEASE-AMYLOID SECRETASE PATHWAY%PANTHER PATHWAY%P00003 Alzheimer disease-amyloid secretase pathway MAPK1 CACNA1S MAPK6 MAPK4 MAPK3 MAPK14 MAPK15 MAPK12 MAPK13 MAPK10 MAPK11 PKN2 CHRFAM7A APBA1 PKN1 APBA3 APBA2 PCSK2 CHRM2 CHRM3 PCSK1 APP CHRM1 CHRM4 CHRM5 PCSK7 PCSK6 PCSK4 KAT5 PSENEN PRKCG PRKCI PRKCH PRKCB PRKCE PRKCD ADAM10 PRKCA CACNB1 BACE1 CACNB2 BACE2 ADAM17 ADAM9 PRKCQ PKN3 CHRNA7 PSEN2 CACNA1D FURIN PSEN1 CACNA1C CACNA1F KLC1 PRKCZ KLC4 MAPK9 KLC3 MAPK8 NCSTN APH1B MAPK7 KLC2 ALZHEIMER DISEASE-PRESENILIN PATHWAY%PANTHER PATHWAY%P00004 Alzheimer disease-presenilin pathway APP FZD10 RBPJ ACTB ACTG2 ACTG1 CDH3 KAT5 CDH1 KAT7 WNT5B WNT5A ERN1 ADAM17 NOTCH2 NOTCH3 NOTCH1 NOTCH4 PSEN2 PSEN1 WNT6 NCSTN APH1B DVL1 DVL2 DVL3 WNT1 WNT2 WNT3 WNT4 FZD1 WNT10B WNT10A FZD3 FZD2 FZD5 JUP FZD4 WNT3A FZD7 FZD6 FZD9 FZD8 LRP1B PCSK2 GSK3B PCSK1 WNT2B PCSK7 PCSK6 PCSK4 MMP21 MMP20 MMP25 MMP24 MMP27 TRIM2 TRIM3 TRPC7 PSENEN ACTR2 TRPC5 MMP7 TRPC6 MMP1 TRPC4 TRPC1 MMP2 WNT9B WNT9A MMP8 WNT16 MMP9 ACTA2 BACE1 ACTA1 BACE2 MMP14 MMP13 ACTBL2 MMP16 MMP15 MMP23B MMP17 MMP19 CD44 RBPJL LRP1 LEF1 WNT8A LRP5 WNT8B LRP4 FURIN LRP3 LRP2 MLLT4 FSTL1 LRP6 WNT11 ERBB4 APBB2 APBB3 TCF7L2 TCF7L1 WNT7B WNT7A ACTC1 CTNNB1 PVRL1 AMINOBUTYRATE DEGRADATION%PANTHER PATHWAY%P02726 Aminobutyrate degradation ABAT ANANDAMIDE_DEGRADATION%PANTHER PATHWAY%P05728 Anandamide_degradation FAAH ANDROGEN ESTROGENE PROGESTERONE BIOSYNTHESIS%PANTHER PATHWAY%P02727 Androgen estrogene progesterone biosynthesis SOAT1 SOAT2 HSD17B1 HSD17B2 HSD17B3 HSD17B6 HSD17B7 CYP19A1 LIPA ANGIOGENESIS%PANTHER PATHWAY%P00005 Angiogenesis WNT7B STAT3 WNT7A MAPK14 DLK1 VEGFA APC CTNNB1 TEK ARAF FGF1 RBPJ ETS1 CRKL GRB14 AKT2 AKT3 KDR AKT1 EPHB2 EPHB1 EPHB3 PDGFRB PRKCG MAP2K4 PDGFRA MAP2K1 PRKCI MAP2K2 PRKCH WNT5B PRKCB PRKCE F2R PRKCD WNT5A FRS2 PRKCA FRS3 DOK1 DOK2 SFRP1 DOK3 MAPKAPK3 PRKD3 MAPKAPK2 PRKD2 PRKCQ PRKD1 RAF1 EPHA3 NOTCH2 GRB7 SHC2 NOTCH1 SHC1 NOTCH4 SH2D2A TCF7 PXN PDGFB PDGFA PIK3R3 PIK3R2 PIK3R1 PLD1 HIF1A PRKCZ PLD2 EFNB2 EFNB1 PDGFD PDGFC DVL1 PLCG2 DVL2 LPXN DVL3 PLCG1 WNT1 WNT2 FZD1 JAG2 WNT10B WNT10A FZD3 JUN FZD2 JAG1 FZD5 BRAF PTK2 PTPRB GRAP FGFR1 PRR5 GSK3B WNT2B ARHGAP8 TGFB1I1 ARHGAP1 HSPB1 PIK3CD PIK3CB PIK3C2A PIK3CG PIK3C2B CASP9 NCK2 HRAS NCK1 JAK1 APC2 PLA2G4D SPHK2 SPHK1 PLA2G4B PLA2G4C AXIN1 PLA2G4A FOS RHOC F3 RHOA RHOB F7 PIK3CA RASA1 BIRC5 PIK3C3 CRYAA SOS1 CRK SOS2 CRYAB RBPJL SRC DLL1 DLL3 DLL4 NRAS PAK1 MAPK8 FRZB MAPK1 PAK3 PAK2 MAPK3 TCF7L2 ANGPT2 MAP3K1 ANGPT1 STAT1 NOS3 ANGIOTENSIN_II-STIMULATED_SIGNALING_THROUGH_G_PROTEINS_AND_BETA-ARRESTIN%PANTHER PATHWAY%P05911 Angiotensin_II-stimulated_signaling_through_G_proteins_and_beta-arrestin AGTR1 GNB4 GNB3 GNB5 RAF1 PLCB1 PLCB2 ITPR1 ITPR2 ARRB1 ITPR3 ARRB2 ELK1 GNG10 GNG3 GNGT2 GRK5 GNG4 ADRBK2 ADRBK1 GNG7 GRK6 MAPK1 GNG8 MAPK3 EGR1 MAP2K1 MAP2K2 PRKCA GNG11 AGT PLCB3 GNB2 GNAQ GNB1 APOPTOSIS SIGNALING PATHWAY%PANTHER PATHWAY%P00006 Apoptosis signaling pathway ATF6B XIAP RELA RELB MAPK9 MAPK8 MAPK1 BAK1 BCL2L2-PABPN1 MAP4K3 MAP4K4 MAPK3 MAP3K1 HSPA1L BIK GZMB CFLAR GZMH MAPK10 PRKRA FAS BAX ATF1 ATF2 TNF AKT2 AKT3 TNFSF10 AKT1 MAP3K5 MAP2K3 PRKCG MAP2K4 DAXX ENDOG PRKCH PRKCB PRKCE PRKCD PRKCA MADD PRKCQ ATF7 TP53 ATF6 ATF3 ATF4 DIABLO CREM BAG4 BCL2L10 BCL2L11 BAG3 RIPK1 FADD MAP2K7 MCL1 HSPA8 JUN HSPA5 CRADD HSPA6 TNFRSF10C EIF2AK2 TNFRSF10B TNFRSF10A HSPA2 EIF2S1 IGF2R NFKB1 TNFRSF10D NFKB2 NFKBIA REL BCL2 CYCS MAP3K14 BCL2L2 BCL2L1 TRADD PIK3CD FASLG PIK3CB PIK3CG IKBKB CASP9 CASP7 CASP8 AIFM1 CASP10 CASP3 BOK MAP4K2 CHUK APAF1 TRAF2 FOS TNFRSF1B TNFRSF1A PIK3CA LTA TMBIM6 LTB JDP2 BIRC2 BIRC3 ARGININE BIOSYNTHESIS%PANTHER PATHWAY%P02728 Arginine biosynthesis CAD ASL NAGS ASS1 OTC CPS1 ASCORBATE DEGRADATION%PANTHER PATHWAY%P02729 Ascorbate degradation RPE ASPARAGINE AND ASPARTATE BIOSYNTHESIS%PANTHER PATHWAY%P02730 Asparagine and aspartate biosynthesis ASNS ATP SYNTHESIS%PANTHER PATHWAY%P02721 ATP synthesis ATP5B ATP5C1 AXON GUIDANCE MEDIATED BY NETRIN%PANTHER PATHWAY%P00009 Axon guidance mediated by netrin NTN4 PIK3R3 PIK3CD PIK3R2 PIK3R1 PIK3CB PIK3C2A NTN1 PIK3CG NTN3 PIK3C2B PIK3R5 CDC42 ABLIM1 PLCG2 RAC2 RAC1 PLCG1 NTNG1 VASP NTNG2 UNC5B DCC NFATC3 NFATC2 UNC5C UNC5D NFATC4 PIK3CA RHOU AXON GUIDANCE MEDIATED BY SEMAPHORINS%PANTHER PATHWAY%P00007 Axon guidance mediated by semaphorins SEMA3A DPYS CRMP1 RHOA PAK1 DPYSL4 CDK5 DPYSL5 FES DPYSL2 RAC2 PLXNA1 PLXNB1 FYN ARHGEF1 RAC1 FRK NRP1 SEMA4D AXON GUIDANCE MEDIATED BY SLIT ROBO%PANTHER PATHWAY%P00008 Axon guidance mediated by Slit Robo NTNG2 DCC NTN4 CXCR4 RHOC NTN1 ROBO1 NTN3 CDC42 CXCL12 SLIT1 RAC2 ABL1 SLIT3 SLIT2 RAC1 SRGAP1 NTNG1 B CELL ACTIVATION%PANTHER PATHWAY%P00010 B cell activation ARAF PIK3CD PIK3CB PIK3CG IKBKB PPP3CA PPP3CB BLNK RAC2 RAC1 HRAS VAV3 MAP2K1 MAP2K2 CHUK SYK PRKCB NFKBIL1 PRKCD FOS VAV1 VAV2 PIK3CA BTK SOS1 RAF1 SOS2 ITPR1 ITPR2 ITPR3 CD79B MAPK9 CD79A NRAS MAPK8 CD19 PLCG2 MAPK1 MAPK3 MAP3K2 LYN MAP3K3 JUN MAPK14 MAPK12 MAPK13 NFKBIA MAPK10 MAPK11 PTPRC GRB2 PTPN6 CD22 BETA1 ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04377 Beta1 adrenergic receptor signaling pathway SNAP25 SNAP23 ADRB1 PRKX ADCY2 ADCY7 GNG10 GNG3 GNG2 GNGT2 GNG5 PRKAR2B GNG4 PRKACG PRKAR2A GNG7 GNG8 STX3 PRKACA SNAP29 PRKACB GNG12 VAMP8 GNAL GNB2 GNB1 GNB4 GNB3 VAMP1 GNB5 VAMP2 VAMP3 BETA2 ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04378 Beta2 adrenergic receptor signaling pathway ADRB2 GNG12 ADCY7 GNG10 GNG3 GNAL GNG2 GNGT2 GNG5 PRKAR2B GNG4 GNB2 PRKACG PRKAR2A GNG7 GNB1 GNB4 GNB3 GNG8 GNB5 PRKACA PRKACB PRKX ADCY2 BETA3 ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04379 Beta3 adrenergic receptor signaling pathway SNAP25 SNAP23 ADCY2 ADCY7 GNG10 GNG3 GNG2 GNGT2 GNG5 GNG4 GNG7 GNG8 STX3 SNAP29 GNG12 VAMP8 GNAL ADRB3 GNB2 GNB1 GNB4 GNB3 VAMP1 GNB5 VAMP2 VAMP3 BIOTIN BIOSYNTHESIS%PANTHER PATHWAY%P02731 Biotin biosynthesis BLOOD COAGULATION%PANTHER PATHWAY%P00011 Blood coagulation PLAU FGB FGA SERPINB2 F10 VWF GP1BB F12 SERPINF2 F2R FGG PLAUR GP1BA F2 GP5 F3 PROCR GP9 F7 F8 PROC F9 F13B KLKB1 F2RL3 APP SERPINA1 SERPINC1 PROS1 SERPINE1 ITGA2B SERPINA10 PROZ PLG PLAT TFPI KNG1 THBD BMP_SIGNALING_PATHWAY-DROSOPHILA%PANTHER PATHWAY%P06211 BMP_signaling_pathway-drosophila BUPROPION_DEGRADATION%PANTHER PATHWAY%P05729 Bupropion_degradation CYP2B6 CADHERIN SIGNALING PATHWAY%PANTHER PATHWAY%P00012 Cadherin signaling pathway PCDHGA1 WNT9B WNT9A WNT16 ACTA2 ACTA1 ACTBL2 CDH10 CDHR1 CDH11 CDHR2 CDH12 PCDHGB1 CDH13 CDH15 CDH16 CDH17 CDH18 CDH19 SRC LEF1 WNT8A WNT8B FSTL1 EGFR WNT11 ERBB3 ERBB4 ERBB2 FYN PCDH1 TCF7L2 PTPN1 TCF7L1 PCDH9 PCDHGC5 PCDH7 PCDHGC4 WNT7B PCDH8 PCDHGC3 PCDHB15 PCDHB14 WNT7A PCDHB13 PCDHB12 PCDHB11 PCDHB10 ACTC1 PCDHB16 CTNNB1 FRK PCDH11Y CTNND2 PCDH11X CTNND1 FZD10 CELSR1 CDH9 CELSR2 ACTB CDH8 CELSR3 ACTG2 CDH7 ACTG1 CDH6 CDH5 CDH4 CDH3 CDH2 CDH1 PCDHAC2 PCDHAC1 WNT5B CSNK2A3 WNT5A CSNK2A2 PCDHA13 PCDHA12 PCDHA11 PCDHA10 CSNK2B PCDH10 PCDH15 PCDH12 PCDH19 PCDH18 WNT6 PCDHA1 CDH20 CDH22 PCDHA5 CDH23 CDH24 PCDHA4 PCDHA3 PCDHA2 WNT1 PCDHA9 PCDHA8 WNT2 WNT3 PCDHA7 WNT4 PCDHA6 FZD1 LYN WNT10B WNT10A FZD3 FZD2 YES1 FZD5 FZD4 WNT3A PCDH20 FZD7 FZD6 FZD9 FZD8 PCDHGA10 PCDHGA11 PCDHGA12 FER PCDHB2 PCDHB1 PCDHB6 FAT1 PCDHB5 FAT2 FAT3 PCDHB4 DCHS1 PCDHB3 PCDHB8 PCDHB7 GSK3B PCDHGB7 WNT2B PCDHGB6 PCDHGB4 PCDHGB2 PCDHGA8 ACTR2 PCDHGA7 PCDHGA6 PCDHGA5 PCDHGA3 PCDHGA2 CARNITINE METABOLISM%PANTHER PATHWAY%P02733 Carnitine metabolism GASTRIN_CCK2R_240212%PANTHER PATHWAY%P06959 Gastrin_CCK2R_240212 ATF2 IRS1 ARAF CLU ELK1 ELK4 RPS6KA3 RGS2 CDH1 PLAU PRKACG RPS6KA1 AKT1 PRKACA PRKACB AP2M1 MEN1 IER3 MAP2K4 MAP2K1 MEF2C MAP2K2 PRKCH MEF2B PRKCB PRKCE RPS6 PRKCD CSNK1D PRKCA CSNK1E TPST1 PRKCQ PRKD2 PRKD1 RAF1 CETP SHC1 ARHGEF28 PDE1A PXN ITPR1 CREM PIK3R1 FOXO3 FOXO1 EIF4EBP1 PLCG1 MAP2K5 MAP2K6 LYN EGR1 JUN YES1 NFATC2 BRAF PTK2 NFKBIA RHEB SP1 GNB1 SP3 BCL2 SNAI1 CPE GRB2 TCF4 MAP3K14 MAP3K11 BCL2L1 RYR1 ITGB1 RYR2 GSK3B CXCL8 YWHAB PTEN HSPB1 PIK3CB ARRB2 ELAVL1 RYR3 ARHGAP4 PPP3CA CASP3 CD38 ITGAV GAST RAC1 NOS1 JAK2 PRKG1 SLC18A2 PDPK1 MMP3 PLA2G4A FOS RHOA DNM1 CNKSR1 CREB1 CCKBR TRAF6 AKT1S1 PPARG SOS1 CRK HBEGF GUCY2D ROCK1 SRC SRF ODC1 ADCY1 NR2C2 PTGS2 CAMKK1 HDAC7 AKAP1 CDC42 MAPK9 MAPK8 PAK1 MAPK7 GNG2 PTK2B MAPK1 CSK MEF2D EIF4E MAPK3 CSNK1A1 BAD STAT3 CCK PTPN11 KLF4 MAPK14 TPCN2 TPCN1 MAPK10 RPS6KB1 CAMK4 BAX CTNNB1 BCAR1 CELL CYCLE%PANTHER PATHWAY%P00013 Cell cycle PSMD12 PSMD11 PSMD14 PSMD13 CCND3 CCND2 PSMD7 PSMD4 CCNE2 CCNE1 RPA3 PSME3 PSMD3 CINP CHOLESTEROL BIOSYNTHESIS%PANTHER PATHWAY%P00014 Cholesterol biosynthesis PDSS1 HMGCR LSS FDFT1 FDPS SQLE MVK GGPS1 HMGCS1 IDI2 PMVK MVD CHORISMATE BIOSYNTHESIS%PANTHER PATHWAY%P02734 Chorismate biosynthesis CIRCADIAN CLOCK SYSTEM%PANTHER PATHWAY%P00015 Circadian clock system PER2 PER1 PER3 CRY2 CRY1 CSNK1D CSNK1E CLOCK ARNTL COBALAMIN BIOSYNTHESIS%PANTHER PATHWAY%P02735 Cobalamin biosynthesis COENZYME A BIOSYNTHESIS%PANTHER PATHWAY%P02736 Coenzyme A biosynthesis PPCS PANK1 DCAKD PANK4 PANK2 PANK3 COENZYME A LINKED CARNITINE METABOLISM%PANTHER PATHWAY%P02732 Coenzyme A linked carnitine metabolism CORTOCOTROPIN RELEASING FACTOR RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04380 Cortocotropin releasing factor receptor signaling pathway SNAP25 SNAP23 CRHR1 CRHR2 GNA14 GNG10 GNG3 GNG2 GNGT2 GNG5 GNG4 GNA11 GNG7 GNG8 STX3 SNAP29 GNG12 VAMP8 POMC GNAL GNB2 GNAQ GNB1 GNB4 CRH GNB3 VAMP1 GNB5 VAMP2 VAMP3 CYSTEINE BIOSYNTHESIS%PANTHER PATHWAY%P02737 Cysteine biosynthesis CBS CYTOSKELETAL REGULATION BY RHO GTPASE%PANTHER PATHWAY%P00016 Cytoskeletal regulation by Rho GTPase ARPC1A ARHGAP1 STMN4 WASL ACTB MYLK3 ACTG2 ACTG1 MYLK TUBB8 TUBB6 TUBB3 CFL2 CFL1 TUBB1 STMN1 RAC2 RAC1 TUBB RHOC ACTA2 ENAH MYH1 ACTA1 TUBB2B MYH2 TUBB2A MYH3 MYO3B ACTBL2 MYO3A MYH8 MYH9 ARHGEF1 RHOU MYH4 PFN1 MYH6 PFN3 MYH7 PFN2 ROCK1 ROCK2 CDC42 PAK1 PAK7 MYH13 MYH14 PAK6 MYH11 PAK3 PAK2 MYH10 PAK4 VASP MYH7B LIMK1 ARPC4 ARPC5 TUBB4B TUBB4A SSH1 DIAPH1 DIAPH2 ACTC1 ARPC2 ARPC3 MYLK2 ARHGAP8 ARPC1B DE NOVO PURINE BIOSYNTHESIS%PANTHER PATHWAY%P02738 De novo purine biosynthesis AK1 GMPS AK2 AK3 AK4 AK5 AK8 ATIC GUK1 PPAT ADSS RRM1 ADSL RRM2 NME2 NME3 NME4 NME5 NME1 RRM2B NME6 NME7 IMPDH2 ADSSL1 DSCAML1 GART DE NOVO PYRIMIDINE DEOXYRIBONUCLEOTIDE BIOSYNTHESIS%PANTHER PATHWAY%P02739 De novo pyrimidine deoxyribonucleotide biosynthesis RRM1 DTYMK DUT RRM2 RRM2B NME2 NME3 NME4 TYMS DSCAML1 NME1 ADAT2 DE NOVO PYRIMIDINE RIBONUCLEOTIDES BIOSYTHESIS%PANTHER PATHWAY%P02740 De novo pyrimidine ribonucleotides biosythesis NME4 CTPS1 DSCAML1 NME1 DHODH CPS1 CAD NME2 NME3 CTPS2 DNA REPLICATION%PANTHER PATHWAY%P00017 DNA replication RFC5 TOP2A TOP2B RFC3 RFC4 PCNA RFC1 RFC2 H3F3C PRIM1 RPA2 POLA1 RNASEH1 POLD1 HIST3H3 POLD2 TOP1 DNA2 PNAT%PANTHER PATHWAY%P05912 PNAT PPP1CA TH GNB2 GNB1 PPP1R1B GNB4 GNB3 KCNK3 CLIC6 SNAP25 KCNK9 SNAP23 DBH COMT SLC6A3 PPP1CC PRKACG PRKACA SNAP29 PRKACB SLC18A2 VAMP8 VAMP1 VAMP2 VAMP3 GNAZ DDC MAOB EPB41 MAOA GNAI3 PRKX ADCY2 ADCY7 GNAI1 GNAI2 GNG3 PRKAR2B GNG4 EPB41L1 PRKAR2A EPB41L2 EPB41L3 FLNA GNG8 STX3 DRD1 DRD2 DRD4 DRD5 GNG11 DPP-SCW_SIGNALING_PATHWAY%PANTHER PATHWAY%P06212 DPP-SCW_signaling_pathway DPP_SIGNALING_PATHWAY%PANTHER PATHWAY%P06213 DPP_signaling_pathway EGF RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00018 EGF receptor signaling pathway MAP3K5 MAP2K3 PRKCG MAP2K4 MAP2K1 PRKCI MAP2K2 PRKCH PRKCB PRKCE PRKCD PRKCA EREG BTC PRKD3 PRKD2 PRKCQ PRKD1 RAF1 PHLDB2 SHC2 SHC3 SHC1 TGFA RASAL2 PRKCZ PIK3R5 RRAS PLCG2 SFN PLCG1 MAP2K7 MAP2K6 STAT5A STAT5B BRAF NF1 GRAP YWHAE YWHAB PIK3CD PIK3CB PIK3C2A AREG PIK3CG PIK3C2B YWHAQ PPP2R5E RAC2 RAC1 HRAS YWHAG YWHAH RASA4B PPP2R5B GAB1 PPP2R5A RRAS2 NRG1 PPP2R5D GAB3 PPP2R5C GAB2 NRG2 YWHAZ MRAS NRG3 PIK3CA RASA4 RASA1 RASA2 PIK3C3 SOS1 SOS2 HBEGF CBL EGFR PPP2CA PPP2CB MAPK9 NRAS MAPK8 ERBB3 ERBB4 ERBB2 STAT4 MAPK1 STAT6 MAPK3 MAP3K2 MAP3K3 EGF STAT1 STAT2 STAT3 SPRY4 DAB2IP MAPK14 MAPK12 MAPK13 MAPK10 MAPK11 SPRY3 SPRY2 SPRY1 ARAF PEBP1 CBLC CBLB AKT2 PEBP4 AKT3 AKT1 MAP3K4 ENDOGENOUS_CANNABINOID_SIGNALING%PANTHER PATHWAY%P05730 Endogenous_cannabinoid_signaling GNG3 GNGT2 GNG5 CNR1 GNG4 GNB2 GNG7 GNB1 GNB4 GNB3 GNG8 PLCB1 PLCB2 CACNA1B GNAI3 CACNA1A GNG11 GNAI1 GRM1 CACNA1G GNAO1 PLCB3 GRM5 UNTITLED%PANTHER PATHWAY%P00019 untitled GUCY1B3 PCSK1 ARAF ECE1 EDNRA EDNRB PRKACG AKT2 AKT3 PRKG2 AKT1 PRKACA PRKACB PRKG1 GUCY1A3 PRKCG GUCY1A2 MAP2K1 PRKCI EDN1 MAP2K2 PRKCH EDN2 EDN3 PRKCB PRKCE PRKCD PLA2G4A PRKCA PLCB3 PLCB4 ADCY9 PRKAR1B PRKAR1A PRKCQ RAF1 PLCB1 PLCB2 ADCY4 ITPR1 ITPR2 ADCY3 ITPR3 FURIN ADCY2 ADCY1 PTGS2 ADCY8 ADCY7 PRKCZ ADCY6 ADCY5 GNA14 PRKAR2B PRKAR2A GNA11 MAPK1 SEC11A SEC11C MAPK3 NOS3 ECEL1 ADCY10 GNAL GNAQ GNAS ENKEPHALIN RELEASE%PANTHER PATHWAY%P05913 Enkephalin release OPRD1 GNAI3 CREM PRKX ADCY2 ADCY7 GNAI1 GNAI2 GNG10 GNG3 GNG2 GNGT2 GNG5 PRKAR2B GNG4 PRKACG PRKAR2A GNG7 PENK GNG8 PRKACA PRKACB OPRM1 GNG12 PDYN GNAO1 GNAL CREB1 GNB2 GNB1 GNB4 GNB3 GNB5 FAS SIGNALING PATHWAY%PANTHER PATHWAY%P00020 FAS signaling pathway FAF1 CAPG FASLG LMNB1 CASP9 MAPK9 MAPK8 CASP7 SCIN CASP8 CASP10 CASP6 CASP3 LMNA CYC1 FADD MAP3K5 DFFB MAP2K4 PARP3 JUN DAXX GSN PARP4 PARP1 APAF1 PARP2 CFLAR MAPK10 FAS FGF SIGNALING PATHWAY%PANTHER PATHWAY%P00021 FGF signaling pathway FGF14 FGF18 GRAP FGFR4 FGF13 FGFR3 FGF12 FGFR2 FGF11 FGFR1 FGF10 YWHAE YWHAB PIK3CD PIK3CB PIK3C2A PIK3CG PIK3C2B YWHAQ PPP2R5E RAC2 RAC1 HRAS YWHAG RASA4B PPP2R5B PPP2R5A PPP2R5D PPP2R5C YWHAZ PIK3CA RASA4 RASA1 RASA2 PIK3C3 SOS1 SOS2 PPP2CA PPP2CB MAPK9 NRAS MAPK8 MAPK1 MAPK3 MAP3K2 MAP3K3 SPRY4 MAPK14 MAPK12 MAPK13 MAPK10 MAPK11 PPP2R2C PPP2R2B PPP2R2D SPRY3 SPRY2 SPRY1 PTPN6 ARAF PEBP1 PPP2R2A FGF1 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 PPP2R1B PPP2R1A AKT2 AKT3 AKT1 MAP3K6 MAP3K4 MAP3K5 MAP2K3 PRKCG MAP2K4 MAP2K1 PRKCI MAP2K2 PRKCH PRKCB PRKCE PRKCD FRS2 PRKCA FRS3 PRKCQ RAF1 SHC3 SHC1 PRKCZ PLCG2 FGF20 SFN PLCG1 MAP2K7 FGF22 MAP2K6 FGF17 FLAVIN BIOSYNTHESIS%PANTHER PATHWAY%P02741 Flavin biosynthesis FLAD1 RFK FORMYLTETRAHYDROFORMATE BIOSYNTHESIS%PANTHER PATHWAY%P02743 Formyltetrahydroformate biosynthesis DHFR MTHFD1L DHFRL1 MTHFD2 MTR TYMS FRUCTOSE GALACTOSE METABOLISM%PANTHER PATHWAY%P02744 Fructose galactose metabolism GALE GALT HKDC1 ALDOC ALDOB ALDOA HK2 KHK HK1 GABA-B_RECEPTOR_II_SIGNALING%PANTHER PATHWAY%P05731 GABA-B_receptor_II_signaling GNAI3 ADCY4 CACNA1B CACNA1A ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 GNAI1 ADCY5 CACNA1G GNG3 GNGT2 GNG5 PRKAR2B GNG4 PRKACG PRKAR2A GNG7 GNG8 PRKACA PRKACB KCNJ3 GABBR2 GABBR1 GNG11 GNAO1 ADCY9 PRKAR1B PRKAR1A GNB2 GNB1 GNB4 GNB3 GAMMA-AMINOBUTYRIC ACID SYNTHESIS%PANTHER PATHWAY%P04384 Gamma-aminobutyric acid synthesis ALDH5A1 GAD1 GAD2 ABAT CSAD GBB_SIGNALING_PATHWAY%PANTHER PATHWAY%P06214 GBB_signaling_pathway GENERAL TRANSCRIPTION REGULATION%PANTHER PATHWAY%P00023 General transcription regulation GTF2E1 GTF2E2 TAF1C POLR2C POLR2F POLR2H TAF9B CFAP20 GTF2A1L BRF2 BRF1 TAF12 MTERF2 TAF11 GTF2H1 GTF2H3 GTF2F1 GTF2H4 GTF2F2 TAF8 TBPL1 TAF7 TAF6 TAF4 TAF2 GTF2A1 GTF2A2 GTF2B TAF9 AK6 TTF1 GENERAL TRANSCRIPTION BY RNA POLYMERASE I%PANTHER PATHWAY%P00022 General transcription by RNA polymerase I TBP RRN3 TTF1 PSMC3IP TAF1B TAF1C TBPL2 POLR1B TAF1A TAF8 UBTF TBPL1 PTRF POLR2K GLUTAMINE GLUTAMATE CONVERSION%PANTHER PATHWAY%P02745 Glutamine glutamate conversion GLUD1 GLUD2 LGSN GLUL GLYCOLYSIS%PANTHER PATHWAY%P00024 Glycolysis ENO1 BPGM ENO2 HK2 HK1 PFKL PKM HKDC1 PGK1 PGAM4 ALDOA GAPDH PFKM GPI TPI1 PKLR PGAM2 UNTITLED%PANTHER PATHWAY%P06664 untitled TGIF1 SKIL RELA HEDGEHOG SIGNALING PATHWAY%PANTHER PATHWAY%P00025 Hedgehog signaling pathway CREBBP CSNK1A1 FBXW11 PTCH1 CSNK1E GLI1 GLI3 SHH PRKAR1B SMO PRKAR2B PRKAR1A STK36 SUFU PRKAR2A UBR5 BTRC CSNK1A1L GSK3B HEME BIOSYNTHESIS%PANTHER PATHWAY%P02746 Heme biosynthesis ALAD FECH QARS UROD RSAD1 HMBS CPOX EPRS PPOX COX10 EARS2 HETEROTRIMERIC G-PROTEIN SIGNALING PATHWAY-GI ALPHA AND GS ALPHA MEDIATED PATHWAY%PANTHER PATHWAY%P00026 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway CLTCL1 DRD1 DRD2 DRD4 DRD5 CREBBP HTR1E HTR1F HTR1D HTR1A HTR1B PHKB GNG12 GNAL GNB2 GNB1 GPSM1 GSK3B PYGB GPSM2 GSK3A CLTC CLTB HTR2B CLTA HTR2C ADRA1D PYGM PYGL HTR2A ADRA1B ADRA1A GRM1 GYS2 GRM3 GNGT1 GYS1 GRM2 GRM5 GNGT2 GRM4 GRM7 GRM6 GRM8 GNRHR OPRM1 SSTR1 ADRA2C SSTR2 SSTR3 SSTR4 SSTR5 CREB3 CREB1 ADRB3 ADORA2A ADORA2B CREB5 OPRD1 RGS18 RGS17 RGS19 RGS14 RGS13 RGS16 OPRL1 GNAI3 ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 GNAI1 GNAI2 ADCY5 GNG3 GNG2 PHKG1 GNG5 ADRBK2 GNG4 ADRBK1 GNG7 PHKG2 GNG8 KCNJ3 KCNJ5 KCNJ6 KCNJ9 OPRK1 GPR50 HTR5A RGS10 RGS12 RGS11 CHRM2 CHRM3 CHRM1 CHRM4 CHRM5 HTR4 RGS4 RGS5 HTR6 RGS2 RGS3 HTR7 CREB3L3 CREB3L4 RGS1 ADORA3 PRKACG CREB3L1 CREB3L2 ADORA1 EP300 RGS8 PRKACA PRKACB RGS9 RGS6 RGS7 PHKA1 PHKA2 MTNR1A ADCY9 PRKAR1B PRKAR1A MTNR1B CREM ADRB1 ADRB2 GRK1 RAP1B HRH1 GNG10 RAP1A HRH3 GRK5 GRK4 PRKAR2B HRH2 GRK7 PRKAR2A HRH4 GRK6 HETEROTRIMERIC G-PROTEIN SIGNALING PATHWAY-GQ ALPHA AND GO ALPHA MEDIATED PATHWAY%PANTHER PATHWAY%P00027 Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway GNRHR BDKRB1 GARNL3 OPRM1 SSTR1 SSTR2 SSTR3 SSTR4 RHOA SSTR5 PLCB3 PLCB4 ADORA2A ADORA2B ARHGEF1 PLCB1 PLCB2 OPRD1 RGS18 RGS17 RGS19 RGS14 GPR45 RGS13 RGS16 OPRL1 GNA14 GNA15 GNG3 GNG2 GNG5 ADRBK2 GNG4 ADRBK1 GNG7 GNA11 GNG8 KCNJ3 KCNJ5 KCNJ6 KCNJ9 OPRK1 RGS10 RGS12 RGS11 CHRM2 CHRM3 CHRM1 CHRM4 CHRM5 RGS4 RGS5 RGS2 RGS3 RGS1 ADORA3 ADORA1 RGS8 RGS9 RGS6 RGS7 PRKCG PRKCI PRKCH PRKCB PRKCE PRKCD PRKCA PRKCQ CACNA1B ITPR1 CACNA1A ITPR2 ITPR3 RASGRP2 PRKCZ DNAJC27 CACNA1E RASGRP1 RAP1GAP RASGRP4 RASGRP3 RAP1B GNG10 RAP1A GRK5 GRK4 GRK7 GRK6 CLTCL1 DRD1 DRD2 DRD4 DRD5 GNG12 GNG13 GNAO1 GNB2 GNAQ GNB1 GNB4 GNB3 GPSM1 GPSM2 CLTC CLTB CLTA GRM1 GRM3 GNGT1 GRM2 GRM5 GNGT2 GRM4 GRM7 GRM6 GRM8 BDKRB2 HETEROTRIMERIC G-PROTEIN SIGNALING PATHWAY-ROD OUTER SEGMENT PHOTOTRANSDUCTION%PANTHER PATHWAY%P00028 Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction CALML3 PDC GRK1 GNGT1 GNG10 GNG3 GNG2 GNGT2 GNG5 GNG4 PRKACG GNG7 RHO CNGA1 GNG8 PDE6B CNGA3 GNAT1 PDE6A PRKACA RGS9 PRKACB RCVRN PDE6G GNG12 GNG13 GNB2 GNB1 GNB4 CNGB3 GNB5 CNGB1 HISTAMINE H1 RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04385 Histamine H1 receptor mediated signaling pathway GNG8 PLCG1 PRKCG PRKCI PRKCH PRKCB PLCL1 PRKCE PRKCD PRKCA GNG12 PLCB3 PLCB4 GNB2 GNAQ GNB1 GNB4 GNB3 PRKCQ GNB5 PLCB1 PLCD4 PLCB2 PLCD1 ITPR1 ITPR2 ITPR3 PRKCZ GNA14 HRH1 GNG10 GNG3 GNG2 GNGT2 PLCZ1 GNG5 GNG4 GNG7 GNA11 PLCG2 PLCE1 HISTAMINE H2 RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04386 Histamine H2 receptor mediated signaling pathway ADCY7 GNG10 GNG3 GNAL GNG2 GNGT2 GNG5 PRKAR2B GNG4 HRH2 GNB2 PRKACG PRKAR2A GNG7 GNB1 GNB4 GNB3 GNG8 GNB5 PRKACA PRKACB PRKX ADCY2 GNG12 HISTAMINE SYNTHESIS%PANTHER PATHWAY%P04387 Histamine synthesis HDC HISTIDINE BIOSYNTHESIS%PANTHER PATHWAY%P02747 Histidine biosynthesis HUNTINGTON DISEASE%PANTHER PATHWAY%P00029 Huntington disease TUBB3 CAPNS2 AKT2 TUBB1 CAPN5 AKT3 CAPN2 ARFIP2 AKT1 CAPN3 EP300 CAPN1 TP63 DYNC2H1 MAP2K4 DYNC1LI1 DYNC1LI2 GAPDHS TP53 OPTN ARL1 KALRN GRIN2A CYC1 MAP2K7 PACSIN1 JUN CREBBP BDNF ARPC5 GRIN2C GRIN2B GRIN2D GRIN3A SYNJ1 SP1 DLG4 MAP3K10 DNAL4 TP73 ARF3 ARF4 TNFAIP8 ARF1 HIP1 GRIK5 ARPC1B ARPC1A CLTB GRIK3 GRIK4 GRIK1 AP2A1 WASL GRIK2 AP2A2 CASP8 CASP3 RAC2 RAC1 IFT57 RAB8A ACTR2 DNAI2 TBP APAF1 TUBB RHOG FOS DYNLL1 DYNLL2 ACTA2 ARL4C ARL4D ACTA1 TUBB2B ARL4A TUBB2A ACTBL2 RHOJ HAP1 GAPDH RHOQ ARF5 ARF6 DNAH3 DYNC1I2 DNAH7 DNAH8 DCTN1 DNAH5 HTT CDC42 MAPK9 DYNC1I1 DYNC1H1 HIP1R TUBB4B TUBB4A GRIN1 CAPN11 ACTC1 CAPN12 CAPN10 TAF4 CYFIP2 CYFIP1 SH3GL3 ARPC5L ACTB ACTG2 ACTG1 TUBB8 TUBB6 CAPN9 CAPNS1 CAPN6 CAPN7 HYPOXIA RESPONSE VIA HIF ACTIVATION%PANTHER PATHWAY%P00030 Hypoxia response via HIF activation EGLN1 EGLN3 CREBBP EGLN2 RORC PTEN ARNT TPTE TXN HIF1A MTOR TXN2 AKT2 AKT3 AKT1 VHL INFLAMMATION MEDIATED BY CHEMOKINE AND CYTOKINE SIGNALING PATHWAY%PANTHER PATHWAY%P00031 Inflammation mediated by chemokine and cytokine signaling pathway COL12A1 ARPC5L ARAF ACTB MYLK PREX1 PRKACG AKT2 AKT3 AKT1 PLCE1 PRKACA PRKACB JUNB PRKCB PRKCE FPR1 FPR3 PRKCZ GNG10 RRAS PLCG2 PLCG1 CCR10 CCR1 MYH7B JUN XCR1 JUND NFATC3 NFATC2 NFATC1 GNG12 NFATC4 GRAP ARPC1B ARPC1A CX3CL1 IKBKB RAC2 CCR9 CCR8 CCR7 RAC1 CCR6 JAK2 CCR5 CCR4 PF4V1 CCR3 CCR2 RHOG RHOC VAV1 RHOA PLCB3 PLCB4 PLCB1 PLCB2 CCL13 CCL11 GNAI3 CXCR5 CXCR4 PRKX ADCY2 CXCR6 PTGS2 RELA ADCY6 GNAI1 GNAI2 RELB ADCY5 PTGS1 PAK1 NRAS CXCR1 CXCR3 CXCR2 PAK7 PAK6 CCL18 PAK3 PAK2 PAK4 CCL22 CCL21 CCL20 STAT3 PLCD4 PLCD1 CCL27 CCL26 PF4 MYLK2 CCL4L2 INPPL1 MYLK3 ACTG2 ACTG1 RGS4 CCRL2 CASK LTB4R2 RAF1 IFNAR1 CCL3L1 SHC1 CCL3L3 C5AR1 ALOX15 ITPR1 ITPR2 ITPR3 ALOX12 GRK6 MYH13 MYH14 MYH11 SOCS6 MYH10 SOCS7 SOCS4 SOCS5 ARPC4 ARPC5 NFKB2 GNAO1 CXCL10 ARPC2 ARPC3 GNAQ COL20A1 GNB3 ITGB1 CXCL8 COL14A1 PTEN PIK3CD PIK3CB ITGAL PIK3CG PLCZ1 ITGB7 VWF CHUK PDPK1 PLA2G4A ACTA2 MYH1 ACTA1 MYH2 MYH3 ACTBL2 IFNG MYO3B PIK3CA COL6A2 MYO3A COL6A1 MYH8 MYH9 COL6A3 SOS1 MYH4 MYH6 MYH7 CX3CR1 NFAT5 CAMK2D ROCK1 RGS13 CAMK2A CDC42 GNA14 GNA15 GNG3 CCL8 GNG2 CCL7 GNG5 GNG4 GNG7 GNA11 CCL5 CCL4 CCL3 GNG8 PTK2B CCL2 MAPK1 MAPK3 PLCL1 ACTC1 ALOX5AP KRAS INSULIN IGF PATHWAY-MITOGEN ACTIVATED PROTEIN KINASE KINASE MAP KINASE CASCADE%PANTHER PATHWAY%P00032 Insulin IGF pathway-mitogen activated protein kinase kinase MAP kinase cascade INS RPS6KA4 RPS6KA3 RPS6KA6 RPS6KA5 RPS6KA2 RPS6KA1 MAPK1 MAPK3 MAP2K3 MAP2K1 MAP2K2 INSR INSRR IGF2 IGF1 FOS IGF2R RPS6KB1 RASA1 RPS6KB2 SOS1 RAF1 SOS2 IRS1 IRS4 IRS2 ELK1 IGF1R INSULIN IGF PATHWAY-PROTEIN KINASE B SIGNALING CASCADE%PANTHER PATHWAY%P00033 Insulin IGF pathway-protein kinase B signaling cascade IGF1 FOXO3 IGF2R FOXO1 IGF1R INS PIK3CA MDM2 MDM4 GSK3B GSK3A IRS1 PDPK1 INSR INSRR INPPL1 IRS4 IGF2 PTEN TSC2 TSC1 IRS2 TPTE INTEGRIN SIGNALLING PATHWAY%PANTHER PATHWAY%P00034 Integrin signalling pathway ARPC1A ITGB2 ILK PIK3CD LAMC2 ITGAE LAMC1 PIK3CB PIK3C2A RND2 ITGAL RND3 PIK3CG PIK3C2B RND1 ITGAX RAC2 COL10A1 ITGB8 ITGAV ITGB7 ITGB6 RAC1 HRAS ITGA4 ITGA3 ITGA2 ITGA1 RHOC ARFGAP1 RHOA RHOB RAP2C ARHGAP10 RAP2A COL2A1 RAP2B ITGAD ACTBL2 PIK3CA COL6A2 COL6A1 ITGA8 RAPGEF1 ITGA7 COL6A3 PIK3C3 ITGA6 ITGA5 SOS1 CRK DOCK1 SOS2 ITGA9 ARF6 LAMA5 COL15A1 LAMA2 SRC LAMA1 LAMA4 COL11A1 COL11A2 LAMA3 NTN4 ASAP1 CDC42 MAPK9 NRAS MAPK8 MICALL1 PTK2B FLNA FLNB CSK FYN MAPK6 MAPK3 MAP3K2 MAP3K3 LAMB3 LAMB2 LAMB4 LAMB1 PTPN12 MAPK13 MAPK10 COL3A1 BCAR1 LIMS2 LIMS1 COL16A1 ITGA2B COL12A1 ARAF ARPC5L ACTB CRKL ACTG1 DMBT1 MAP3K4 MAP3K5 MAP2K3 MAP2K4 MAP2K1 COL27A1 MAP2K2 ACTN2 ACTN1 ACTN4 COL4A2 COL4A1 COL4A4 COL4A3 COL4A6 COL8A2 ELMO1 COL4A5 ELMO2 COL8A1 RAF1 TLN1 VCL COL17A1 COL13A1 SHC1 PXN ARL1 PIK3R3 PIK3R2 PIK3R1 DNAJC27 RAP1B RAP1A RRAS VASP CAV1 FN1 BRAF PARVB ARPC5 ARHGAP26 PTK2 COL1A1 COL1A2 ARPC2 COL5A1 ARPC3 COL5A3 ITGA10 COL5A2 ITGA11 COL9A1 COL20A1 ITGBL1 COL9A3 COL9A2 ITGB1 ARF1 ITGAM ITGB5 LAMC3 COL14A1 ITGB4 ARPC1B INTERFERON-GAMMA SIGNALING PATHWAY%PANTHER PATHWAY%P00035 Interferon-gamma signaling pathway SOCS2 MAPK9 SOCS3 MAPK8 MAPK1 JAK2 SOCS6 SOCS7 SOCS4 JAK1 SOCS5 MAPK3 PIAS4 PIAS3 CISH STAT1 IFNGR1 IFNGR2 MAPK14 MAPK15 MAPK12 PIAS2 PIAS1 MAPK13 MAPK10 MAPK11 IFNG PTPN6 INTERLEUKIN SIGNALING PATHWAY%PANTHER PATHWAY%P00036 Interleukin signaling pathway STAT6 MAPK6 IL12RB1 IL12RB2 MAPK3 STAT5A STAT5B STAT1 NOS3 IL10RB IL10RA STAT2 STAT3 BRAF MAPK15 MTOR IL4 IL6 IL2RA IL2RB IL9 IL21 GSK3B CDKN1A SPI1 CDKN1B CXCL8 IRS1 ARAF IL5RA IRS2 PIK3CB SLA2 ELK1 ELK3 IKBKB ELK4 RPS6KA3 SPIC RPS6KA6 MYC RPS6KA2 AKT2 RPS6KA1 AKT3 AKT1 IL13RA2 IL6R JAK3 IL13RA1 IL15RA IL11 IL4R CHUK IL15 IL11RA PDPK1 FOS IL1A PIK3CA IL23A RASA1 IL3RA MAPKAPK2 SOS1 IL6ST RAF1 SOS2 SHC1 SRF IL20RA FOXO3 NRAS MAPK7 CXCR1 MKNK1 MKNK2 CXCR2 STAT4 MAPK1 IONOTROPIC GLUTAMATE RECEPTOR PATHWAY%PANTHER PATHWAY%P00037 Ionotropic glutamate receptor pathway SHANK1 CAMK2B GRIA1 SNAP25 GRIA2 CAMK2D GRIK5 STX19 SNAP23 CAMK2A SLC1A1 GRIK3 SLC1A2 SLC1A3 GRIK4 GRIK1 GRIK2 SLC1A6 SLC1A7 STX11 GRM3 GRM2 GRIN2A SLC17A6 SLC17A8 CACNG2 SNAP29 GRIA3 CACNG5 GRIA4 NSF GRIN2C GRIN2B GRIN1 GRIN2D VAMP8 GRIN3A PICK1 VAMP1 VAMP2 VAMP3 ISOLEUCINE BIOSYNTHESIS%PANTHER PATHWAY%P02748 Isoleucine biosynthesis ILVBL BCAT1 BCAT2 JAK STAT SIGNALING PATHWAY%PANTHER PATHWAY%P00038 JAK STAT signaling pathway STAT5A PIAS3 STAT5B STAT1 STAT3 MAPK14 PIAS2 PIAS1 SOCS1 PTPRC STAT4 STAT6 JAK2 JAK3 JAK1 LEUCINE BIOSYNTHESIS%PANTHER PATHWAY%P02749 Leucine biosynthesis BCAT1 BCAT2 LIPOATE_BIOSYNTHESIS%PANTHER PATHWAY%P02750 Lipoate_biosynthesis LIAS LYSINE BIOSYNTHESIS%PANTHER PATHWAY%P02751 Lysine biosynthesis MANNOSE METABOLISM%PANTHER PATHWAY%P02752 Mannose metabolism PMM1 GMDS MPI PMM2 GMPPA GMPPB METABOTROPIC GLUTAMATE RECEPTOR GROUP III PATHWAY%PANTHER PATHWAY%P00039 Metabotropic glutamate receptor group III pathway PRKACB VAMP8 CACNB1 STX1B PRKAR1B PRKAR1A VAMP1 STX1A VAMP2 VAMP3 GRIA1 GRIA2 SLC1A1 SLC1A2 GNAI3 CACNA1B CACNA1A SLC1A3 PRKX SLC1A6 CACNA1E SLC1A7 GNAI1 GNAI2 GRIN2A GNG10 GNG3 GNG5 PRKAR2B GNG4 PRKAR2A GNG7 VTI1A GNG8 SLC17A7 GRIA3 GRIA4 GRIN2C GRIN2B GRIN1 GRIN2D ADCY10 GRIN3A GNB2 GNB1 GNB4 GNB3 GNB5 SNAP25 GRIK5 SNAP23 GRIK3 GRIK4 GRIK1 GRIK2 GRM1 GRM5 GRM4 GNGT2 GRM7 GRM6 PRKACG GRM8 PRKACA SNAP29 METABOTROPIC GLUTAMATE RECEPTOR GROUP II PATHWAY%PANTHER PATHWAY%P00040 Metabotropic glutamate receptor group II pathway SNAP29 PRKACB GNG11 CACNB1 VAMP8 GNAO1 ADCY10 STX1B PRKAR1B PRKAR1A GNB2 GNB1 GNB4 GNB3 VAMP1 GNB5 VAMP2 STX1A VAMP3 SNAP25 SNAP23 GNAI3 CACNA1B CACNA1A PRKX CACNA1E GNAI1 GNAI2 GRM3 GRM2 GNG10 GNG3 GNGT2 GNAT2 GNG5 PRKAR2B GNG4 PRKACG PRKAR2A GNG7 GNG8 PRKACA METABOTROPIC GLUTAMATE RECEPTOR GROUP I PATHWAY%PANTHER PATHWAY%P00041 Metabotropic glutamate receptor group I pathway PLCB4 GRIN3A PRKAR1B PRKAR1A PRKACG GNAQ GNA11 PRKACA PRKACB GRINA HOMER1 PRKCB GRIK5 ITPR1 PRKX GRIK1 GRIN2C GRIN2B GRM1 GRIN1 GRIN2D GRIN2A GNA15 GRM5 METHIONINE BIOSYNTHESIS%PANTHER PATHWAY%P02753 Methionine biosynthesis MTR METHYLCITRATE CYCLE%PANTHER PATHWAY%P02754 Methylcitrate cycle IREB2 ACO1 METHYLMALONYL PATHWAY%PANTHER PATHWAY%P02755 Methylmalonyl pathway MCEE PCCA PCCB MUT MRNA SPLICING%PANTHER PATHWAY%P00058 mRNA splicing ZRSR1 ZRSR2 SNRNP40 PRPF3 SNRPB2 SNRPA MUSCARINIC ACETYLCHOLINE RECEPTOR 1 AND 3 SIGNALING PATHWAY%PANTHER PATHWAY%P00042 Muscarinic acetylcholine receptor 1 and 3 signaling pathway SNAP25 ACHE CHRM3 CHRM1 SNAP23 GNGT2 SNAP29 SLC18A3 PRKCG PRKCI PRKCH PRKCB PRKCE PRKCD PRKCA VAMP8 STX1B SLC5A7 PLCB4 VAMP1 PRKCQ STX1A VAMP2 VAMP3 PKN3 CHAT ITPR1 ITPR2 ITPR3 PRKCZ GNA14 GRIN2A GNG10 GNG3 GNG5 GNG4 GNG7 GNA11 GNG8 BCHE GRIN2C GNG11 GRIN2B GRIN1 GRIN2D GRIN3A GNB2 GNAQ GNB1 GNB4 GNB3 PKN2 PKN1 GNB5 MUSCARINIC ACETYLCHOLINE RECEPTOR 2 AND 4 SIGNALING PATHWAY%PANTHER PATHWAY%P00043 Muscarinic acetylcholine receptor 2 and 4 signaling pathway CHRM2 SNAP25 ACHE CHRM4 SNAP23 GNGT2 GNAT2 PRKACG GNAT1 PRKACA SNAP29 PRKACB SLC18A3 VAMP8 STX1B SLC5A7 PRKAR1B PRKAR1A VAMP1 STX1A VAMP2 VAMP3 STX16 STX19 CHAT GNAI3 PRKX GNAI1 STX11 GNAI2 GNG10 GNG3 GNG5 PRKAR2B GNG4 PRKAR2A GNG7 GNG8 STX4 KCNJ3 KCNJ5 BCHE KCNJ6 KCNJ9 GNG11 GNAO1 ADCY10 SLC6A8 GNB2 GNB1 GNB4 GNB3 GNB5 MYO_SIGNALING_PATHWAY%PANTHER PATHWAY%P06215 MYO_signaling_pathway N-ACETYLGLUCOSAMINE METABOLISM%PANTHER PATHWAY%P02756 N-acetylglucosamine metabolism GNPDA1 GNPDA2 AMDHD2 GFPT2 GFPT1 NPL NICOTINE_DEGRADATION%PANTHER PATHWAY%P05914 Nicotine_degradation UGT1A4 UGT1A3 FMO3 INMT UGT2B7 CYP2A7 CYP2A6 CYP2A13 UGT1A5 NICOTINE PHARMACODYNAMICS PATHWAY%PANTHER PATHWAY%P06587 Nicotine pharmacodynamics pathway EPB41 CHRNA6 ADCY2 CACNA1C GNAI1 CACNA1G GNG2 EPB41L1 EPB41L2 FLNA PRKACA DRD2 DRD4 SLC18A2 CHRNB2 CHRNB4 CHRNB3 PPP1CA TH GNB1 PPP1R1B KCNK3 CLIC6 DDC CHRNA3 KCNK9 CHRNA5 CHRNA4 NICOTINIC ACETYLCHOLINE RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00044 Nicotinic acetylcholine receptor signaling pathway MYO7B MYO7A ACTA2 VAMP8 MYH1 SLC5A7 ACTA1 STX1B MYH2 MYH3 MYO3B ACTBL2 CTAGE4 MYO3A MYH8 CTAGE9 MYH9 VAMP1 MYH4 STX1A MYH6 VAMP2 MYH7 VAMP3 CTAGE15 CHRNA1 CHRNA3 CHRNA2 PLEKHH3 CHRNA5 STX16 CHRNA4 STX19 CHRNA7 CHRNA6 CHAT CHRNA9 STX11 CHRND CHRNG CHRNE MYO6 MYH13 MYH14 CHRNA10 MYH11 STX4 MYH10 MYH7B BCHE MYO10 MYO5A MYO9A MYO19 MYO16 MYO1D MYO1E MYO1B ACTC1 MYO1C SLC6A8 MYO1A MYO15A MYO5B MYO5C CHRFAM7A MYO1F MYO1G SNAP25 ACHE SLC44A3 SNAP23 ACTB ACTG2 ACTG1 ACTR1A ACTR1B MYO18B MYO18A SNAP29 SLC18A3 CHRNB2 CHRNB1 CHRNB4 CHRNB3 MYH15 NOTCH SIGNALING PATHWAY%PANTHER PATHWAY%P00045 Notch signaling pathway NEURL1 NUMB LNX1 LNX2 NOTCH2 RBPJL NOTCH3 NOTCH1 MAML1 NOTCH4 PSEN1 RBPJ DLL3 DLL4 LFNG NCSTN FUT8 POFUT1 CIR1 JAG2 JAG1 FBXW7 ADAM10 DLK1 NCOR2 ADAM17 NEURL4 NEURL2 MFNG O-ANTIGEN BIOSYNTHESIS%PANTHER PATHWAY%P02757 O-antigen biosynthesis TGDS GFPT2 GFPT1 UNTITLED%PANTHER PATHWAY%P05916 untitled SNAP25 SNAP23 GNAI3 OXT ADCY2 ADCY7 GNAI1 GNAI2 GNG10 GNG3 GNG2 GNGT2 GNG5 GNG4 GNG7 GNG8 STX3 SNAP29 OPRK1 GNG12 PDYN VAMP8 GNAO1 GNB2 GNB1 GNB4 GNB3 VAMP1 GNB5 AVP VAMP2 VAMP3 OPIOID PROENKEPHALIN PATHWAY%PANTHER PATHWAY%P05915 Opioid proenkephalin pathway SNAP25 SNAP23 GNAI3 ADCY2 ADCY7 GNAI1 GNAI2 GNG10 GNG3 GNG2 GNGT2 GNG5 GNG4 GNG7 PENK GNG8 STX3 SNAP29 GNG12 PDYN VAMP8 GNB2 GNB1 GNB4 GNB3 VAMP1 GNB5 VAMP2 VAMP3 OPRD1 OPIOID PROOPIOMELANOCORTIN PATHWAY%PANTHER PATHWAY%P05917 Opioid proopiomelanocortin pathway OPRD1 SNAP25 SNAP23 GNAI3 ADCY2 ADCY7 GNAI1 GNAI2 GNG10 GNG3 GNG2 GNGT2 GNG5 GNG4 GNG7 GNG8 STX3 SNAP29 GNG12 VAMP8 POMC GNAO1 GNB2 GNB1 GNB4 GNB3 VAMP1 GNB5 VAMP2 VAMP3 ORNITHINE DEGRADATION%PANTHER PATHWAY%P02758 Ornithine degradation ODC1 AZIN2 AZIN1 OXIDATIVE STRESS RESPONSE%PANTHER PATHWAY%P00046 Oxidative stress response MAX DUSP19 TXN DUSP18 DUSP15 ELK1 DUSP16 DUSP13 DUSP14 MAPK9 DUSP12 MAPK8 DUSP10 EEF2K MYC MKNK1 MKNK2 MAP2K6 DUSP4 MAP2K3 MAP2K4 DUSP5 MEF2C DUSP2 JUN DUSP3 STAT1 DUSP1 STYX PLA2G4A DUPD1 DUSP8 DUSP26 MAPK14 DUSP27 DUSP9 DUSP6 MAPK12 DUSP7 MAPK13 DUSP22 MAPK11 DUSP21 DDIT3 BCL2 OXYTOCIN RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04391 Oxytocin receptor mediated signaling pathway GNG8 PLCG1 STX3 SNAP29 PRKCG PRKCI PRKCH PRKCB PLCL1 PRKCE PRKCD PRKCA GNG12 VAMP8 PLCB3 PLCB4 GNB2 GNAQ GNB1 GNB4 GNB3 VAMP1 PRKCQ GNB5 PLCB1 PLCD4 PLCB2 VAMP2 PLCD1 VAMP3 SNAP25 OXTR SNAP23 PRKCZ GNA14 GNG10 GNG3 GNG2 GNGT2 PLCZ1 GNG5 GNG4 GNG7 GNA11 PLCG2 PLCE1 P38 MAPK PATHWAY%PANTHER PATHWAY%P05918 p38 MAPK pathway HSPB1 ELK1 RPS6KA4 DUSP10 EEF2K RPS6KA5 MKNK1 MKNK2 MEF2D MAP3K7 EIF4E MAP3K4 MAP2K6 MAP3K5 MAP2K4 MEF2C MEF2B IL1R1 GADD45A DUSP1 MAPK14 MAPK12 MAPK13 MAPK11 MAPKAPK3 TRAF6 MAPKAPK2 MAP3K10 TAB2 TAB1 ATF1 SRF P53 PATHWAY BY GLUCOSE DEPRIVATION%PANTHER PATHWAY%P04397 p53 pathway by glucose deprivation IGBP1 PRKAB2 PRKAA1 PRKAA2 PRKAG1 TSC2 TSC1 PRKAB1 PPP2CA PPP2CB STK11 RPS6KB1 RHEB AKT2 RPS6KB2 AKT3 EIF4EBP1 AKT1 TP53 TP63 TP73 P53 PATHWAY FEEDBACK LOOPS 1%PANTHER PATHWAY%P04392 P53 pathway feedback loops 1 RFWD2 MDM2 MDM4 TP53 TP63 TP73 P53 PATHWAY FEEDBACK LOOPS 2%PANTHER PATHWAY%P04398 p53 pathway feedback loops 2 PIK3R5 PPP2CA PPP2CB NRAS MYC AKT2 AKT3 AKT1 HRAS TP63 PDPK1 SIAH1 MAPK14 MAPK12 MAPK13 CCNA2 CCNA1 MAPK11 RBL1 PIK3CA CCNE1 CCNG1 CDK2 CTNNB1 KRAS PIK3C3 ATM TP53 TP73 ATR RB1 CDKN1A PTEN PIK3R3 PIK3CD TPTE PIK3C2G PIK3R2 PIK3R1 PIK3CB PIK3C2A PIK3CG PIK3C2B P53 PATHWAY%PANTHER PATHWAY%P00059 p53 pathway GADD45G KAT2B PIK3CA KAT6B CCNE1 CDK2 CDK1 MDM2 ATM MDM4 TP53 TP73 ATR CDKN1A HDAC1 PTEN TPTE HMGB1 PPP2CA PPP2CB CCNB1 WRN SUMO1 SIN3A SUMO3 CHEK2 AKT2 SUMO2 AKT3 EP300 AKT1 SFN MTA2 GTSE1 TP63 CDKN2D CREBBP GADD45B CDKN2A PDPK1 GADD45A TRAF2 CDC25C SIRT1 PML PANTOTHENATE BIOSYNTHESIS%PANTHER PATHWAY%P02761 Pantothenate biosynthesis PARKINSON DISEASE%PANTHER PATHWAY%P00049 Parkinson disease MAPK3 HSPA9 LYN HSPA8 TOR1A YES1 HSPA5 HSPA1L CSNK1A1 HSPA6 HSPA2 SNCAIP MAPK14 MAPK15 MAPK12 MAPK10 TH STUB1 CSNK1A1L FRK YWHAE TOR2A YWHAB UBE2L6 ELK1 PARK2 SLC6A3 UBE2L3 UCHL1 YWHAQ YWHAG YWHAH CSNK1G3 GPR37 FBXW7 FBXW11 CSNK2A3 CSNK2A2 STX7 CASK CSNK1D CSNK1E GPR37L1 SEPT4 YWHAZ SEPT5 SEPT2 FGR PSMA5 PSMA6 HCK PSMA3 PSMA4 PSMA1 CCNE2 PSMA2 CCNE1 LCK CSNK2B CSNK1G2 BLK STX12 SRC CUL1 UBE2J2 PSMA7 PSMB10 PSMA8 PLD2 MAPK9 PSMB7 MAPK8 MAPK7 PSMB3 ADRBK2 ADRBK1 PSMB1 SNCG MAPK1 SFN CSK FYN NDUFV2 SNCB SNCA PDGF SIGNALING PATHWAY%PANTHER PATHWAY%P00047 PDGF signaling pathway RPS6KB1 RPS6KB2 PKN2 EHF ARAF ELK1 ETS1 ELK4 RPS6KA4 RPS6KA3 ARHGAP42 RPS6KA6 RPS6KA5 OPHN1 MYC RPS6KA2 GRAP2 AKT2 RPS6KA1 MAP3K4 PDGFRB PDGFRA MAP2K1 MAP2K2 PRKCA PDGFRL MAPKAPK2 ERF ERG RAF1 SHC2 SHC3 SHC1 PDGFB ITPR1 ITPR2 PDGFA PIK3R3 PIK3R2 ITPR3 PIK3R1 ARHGAP15 ARHGAP12 PIK3R5 PLCG2 SRGAP3 PLCG1 SRGAP1 STAT5A STAT5B JUN BRAF ARHGAP26 FLI1 FEV GRB2 GRAP ARHGAP9 GSK3B GSK3A ARHGAP8 ARHGAP1 PIK3CD IKBKAP PIK3CB ARHGAP5 ARHGAP6 PIK3CG RERG ARHGAP4 IKBKB NCK2 JAK2 NINL HRAS JAK3 GABPA NCK1 JAK1 VAV3 RASA4B CHUK PDPK1 GAB1 FOS GAB2 ETV3 VAV1 VAV2 ARHGAP10 ELF1 ELF2 ELF3 PIK3CA ELF4 RASA4 ELF5 RASA1 RASA2 PIK3C3 SOS1 SOS2 MYCBP SRF NRAS MAPK8 MAPK7 RPS6KC1 MKNK1 MKNK2 STAT4 MAPK1 STAT6 MAPK6 SPDEF MAPK3 MAP3K2 STAT1 STAT2 STAT3 USF2 MAPK15 RAB11B MAPK10 NIN PENTOSE PHOSPHATE PATHWAY%PANTHER PATHWAY%P02762 Pentose phosphate pathway RPIA GPI HKDC1 TALDO1 TKT PGD HK2 HK1 PEPTIDOGLYCAN BIOSYNTHESIS%PANTHER PATHWAY%P02763 Peptidoglycan biosynthesis PHENYLALANINE BIOSYNTHESIS%PANTHER PATHWAY%P02765 Phenylalanine biosynthesis PHENYLETHYLAMINE DEGRADATION%PANTHER PATHWAY%P02766 Phenylethylamine degradation AOC3 AOC1 AOC2 PHENYLPROPIONATE DEGRADATION%PANTHER PATHWAY%P02767 Phenylpropionate degradation PI3 KINASE PATHWAY%PANTHER PATHWAY%P00048 PI3 kinase pathway NRAS INPP5A GNGT2 GNAT2 AKT2 GNA11 AKT3 AKT1 JAK2 NOS3 PDPK1 INSR YWHAZ RPS6KB1 PIK3CA GNB2 GNAQ GNB1 RPS6KB2 GNB4 GNB3 GNB5 SOS1 SOS2 GSK3B IRS1 PTGER1 INPPL1 GNAI3 PTEN PIK3R3 PIK3R2 PIK3R1 FOXO4 PIK3CB FOXO3 GNAI1 FOXO1 GNAI2 PIK3R5 CASP9 GNGT1 GNA14 PLASMINOGEN ACTIVATING CASCADE%PANTHER PATHWAY%P00050 Plasminogen activating cascade FGB FGA CPB2 SERPINB2 MMP1 SERPINE1 MMP3 SERPINF2 FGG PLAUR PLG PLAT MMP9 MMP13 PLAU LPA PROLINE BIOSYNTHESIS%PANTHER PATHWAY%P02768 Proline biosynthesis PRPP BIOSYNTHESIS%PANTHER PATHWAY%P02760 PRPP biosynthesis PURINE METABOLISM%PANTHER PATHWAY%P02769 Purine metabolism NT5E GDA AMPD3 XDH PYRIDOXAL-5-PHOSPHATE BIOSYNTHESIS%PANTHER PATHWAY%P02759 Pyridoxal-5-phosphate biosynthesis PSAT1 PNPO PYRIDOXAL PHOSPHATE SALVAGE PATHWAY%PANTHER PATHWAY%P02770 Pyridoxal phosphate salvage pathway PDXK PNPO PYRIMIDINE METABOLISM%PANTHER PATHWAY%P02771 Pyrimidine Metabolism CDA NT5E ALDH6A1 DPYSL5 DPYSL2 DPYS DPYD DPYSL3 ABAT UPB1 PYRUVATE METABOLISM%PANTHER PATHWAY%P02772 Pyruvate metabolism ACLY PDHA2 PDHA1 PKM PC PKLR ME1 PCK1 CLYBL CS RAS PATHWAY%PANTHER PATHWAY%P04393 Ras Pathway GSK3B ATF2 GSK3A ARAF MAP3K7CL PIK3CD PIK3CB ETS1 ELK1 PIK3CG RPS6KA3 RPS6KA6 RPS6KA2 RPS6KA1 AKT3 RAC2 RAC3 AKT1 RAC1 HRAS MAP3K4 MAP2K3 MAP2K4 MAP2K1 MAP2K2 PDPK1 RHOC RHOA RHOB TIAM1 MAPKAPK3 PIK3CA MAPKAPK2 PIK3C3 SOS1 RAF1 SOS2 EXOC2 RALA RALB SHC1 SRF PLD1 PLD2 CDC42 MAPK9 NRAS PAK1 MAPK8 MAPK1 PAK3 MAP2K7 PAK2 RALGDS MAP2K6 MAPK3 JUN MAP3K1 STAT1 STAT3 BRAF MAPK14 MAPK12 MAPK13 MAPK10 MAPK11 GRB2 KRAS RGL1 RGL2 S-ADENOSYLMETHIONINE BIOSYNTHESIS%PANTHER PATHWAY%P02773 S-adenosylmethionine biosynthesis MAT2A MTR MAT1A SALVAGE PYRIMIDINE DEOXYRIBONUCLEOTIDES%PANTHER PATHWAY%P02774 Salvage pyrimidine deoxyribonucleotides CDA TK1 ADAT2 SALVAGE PYRIMIDINE RIBONUCLEOTIDES%PANTHER PATHWAY%P02775 Salvage pyrimidine ribonucleotides NME3 UPRT UPP2 NME4 UPP1 ADAT2 UCKL1 UCK2 UCK1 NME2 SCW_SIGNALING_PATHWAY%PANTHER PATHWAY%P06216 SCW_signaling_pathway SERINE GLYCINE BIOSYNTHESIS%PANTHER PATHWAY%P02776 Serine glycine biosynthesis PSAT1 PHGDH PSPH SUCCINATE TO PROPRIONATE CONVERSION%PANTHER PATHWAY%P02777 Succinate to proprionate conversion PCCB ECHDC1 MUT SULFATE ASSIMILATION%PANTHER PATHWAY%P02778 Sulfate assimilation SYNAPTIC_VESICLE_TRAFFICKING%PANTHER PATHWAY%P05734 Synaptic_vesicle_trafficking UNC13B SYT5 NSF UNC13C SNAP25 SYT3 SYT2 RAB3A SYT1 STXBP1 SYT15 SYT7 UNC13D SYT6 STX1B RIMS1 SYT12 SYT11 VAMP1 STX2 STX1A TCA CYCLE%PANTHER PATHWAY%P00051 TCA cycle PDK2 CS FH PDHA2 PDHA1 MDH1 OGDH SUCLG1 SDHC ACO2 T CELL ACTIVATION%PANTHER PATHWAY%P00053 T cell activation CD86 CD80 ARAF PIK3CD CD3G PIK3CB CD3E CD3D PIK3CG IKBKB PPP3CA PPP3CB PPP3CC GRAP2 AKT2 AKT3 NCK2 AKT1 RAC1 HRAS NCK1 VAV3 MAP2K1 MAP2K2 CHUK FOS VAV1 VAV2 ZAP70 PIK3CA LCK LCP2 PRKCQ PIK3C3 SOS1 RAF1 SOS2 ITPR1 WAS PIK3R3 PIK3R2 PIK3R1 CDC42 MAPK9 NRAS PAK1 MAPK8 MAPK1 CSK PLCG1 PAK3 PAK2 MAPK3 JUN MAP3K1 BRAF NFKBIA PTPRC CD28 CD247 LAT TETRAHYDROFOLATE BIOSYNTHESIS%PANTHER PATHWAY%P02742 Tetrahydrofolate biosynthesis FPGS TYMS DHFR DHFRL1 GCH1 TGF-BETA SIGNALING PATHWAY%PANTHER PATHWAY%P00052 TGF-beta signaling pathway ACVRL1 ATF2 BMP10 BMPR2 AMHR2 CITED1 MSTN ZFYVE9 CITED2 MAP3K7CL BMP15 SNIP1 EP300 HRAS JUNB MAP3K7 ACVR1 LEFTY1 FOXH1 TGFBR1 TGFBR2 ZFYVE16 FKBP2 ACVR1B MAPK9 NRAS MAPK8 ACVR1C RRAS MAPK1 LEFTY2 SKIL MAPK3 GDF10 SMAD2 SMAD1 GDF11 TGFB2 JUN SMAD4 CREBBP SMAD3 JUND SMURF2 TGFB3 GDF15 SMURF1 BMP8A GDF2 GDF1 BMP8B SMAD9 INHBB INHBA GDF3 SMAD6 GDF6 MAPK14 INHBC SMAD5 BMP7 GDF5 ACVR2B BMP6 ACVR2A MAPK12 BMP5 MAPK13 SMAD7 INHBE GDF7 FKBP1A BMP4 MAPK10 FOSL1 SKI MAPK11 BMP3 GDF9 BMP2 BMP1 GDNF BAMBI FKBP1C FKBP1B TLL2 TLL1 TAB1 BMPR1B NODAL DCP1B BMPR1A THIAMIN BIOSYNTHESIS%PANTHER PATHWAY%P02779 Thiamin biosynthesis THIAMINE METABOLISM%PANTHER PATHWAY%P02780 Thiamine metabolism THTPA TPK1 THREONINE BIOSYNTHESIS%PANTHER PATHWAY%P02781 Threonine biosynthesis THNSL1 THYROTROPIN-RELEASING HORMONE RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04394 Thyrotropin-releasing hormone receptor signaling pathway PLCD4 PLCD1 SNAP25 SNAP23 TRH GNGT2 PLCZ1 PLCE1 SNAP29 TSHB PRKCG PRKCI PRKCH PRKCB PRKCE PRKCD PRKCA TRHR VAMP8 CACNB1 CACNB2 CACNB3 PLCB3 PLCB4 CACNB4 VAMP1 PRKCQ PLCB1 PLCB2 VAMP2 VAMP3 CACNA1B CACNA1A CACNA1E PRKCZ GNA14 GNG10 GNG3 GNG2 GNG5 GNG4 GNG7 GNA11 PLCG2 GNG8 PLCG1 STX3 CGA PLCL1 GNG12 GNB2 GNAQ GNB1 GNB4 GNB3 GNB5 TOLL_PATHWAY_DROSOPHILA%PANTHER PATHWAY%P06217 Toll_pathway_drosophila TOLL RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00054 Toll receptor signaling pathway TBK1 IRAK1 MAP3K8 CD14 IKBKE MAP3K7 MAPK3 MAP2K3 MAP2K1 JUN MAP2K2 TICAM2 CHUK IRAK3 IRAK4 TICAM1 MAPK14 TIRAP NFKBIA IRF3 TOLLIP TRAF6 UBE2N TLR9 TLR8 TLR7 TLR10 UBE2V1 TAB1 TLR6 NFKBIE TLR4 TLR3 MYD88 TLR2 LY96 TNFAIP3 ECSIT ELK1 TANK IKBKB MAPK9 MAPK8 TRANSCRIPTION REGULATION BY BZIP TRANSCRIPTION FACTOR%PANTHER PATHWAY%P00055 Transcription regulation by bZIP transcription factor TBP TAF12 BRF1 MTERF2 TAF11 GTF2H1 GTF2F1 GTF2H3 GTF2F2 GTF2H4 PRKAR1B PRKAR1A TBPL2 TAF8 TAF7 TBPL1 TAF6 TAF4 TAF2 CREB5 GTF2A1 GTF2A2 GTF2B TAF9 TTF2 AK6 TTF1 GTF2E1 GTF2E2 PSMC3IP CREB3L3 CREB3L4 TAF1C PRKAR2B PRKAR2A POLR2C CREB3L1 CREB3L2 POLR2E EP300 POLR2F POLR2H TAF9B CFAP20 POLR2L GTF2A1L CREBBP BRF2 TRIACYLGLYCEROL METABOLISM%PANTHER PATHWAY%P02782 Triacylglycerol metabolism LIPE LIPC TRYPTOPHAN BIOSYNTHESIS%PANTHER PATHWAY%P02783 Tryptophan biosynthesis TYROSINE BIOSYNTHESIS%PANTHER PATHWAY%P02784 Tyrosine biosynthesis UBIQUITIN PROTEASOME PATHWAY%PANTHER PATHWAY%P00060 Ubiquitin proteasome pathway UBE2N UBA3 MDM2 UBA2 UBA1 SAE1 UBE2K UBE3C UBA7 UBE2D4 PSMD14 PSMD13 UBA6 UBE2D2 UBE2D3 UBE2D1 UBE2L6 UBE3A UBE3B UBE2L3 PSMD7 PSMD4 PSMD2 PSMD1 ATG7 SMURF2 UBE2B UBE2C SMURF1 UBE2E3 TREX2 UBE2E1 WWP1 UBE2E2 WWP2 UBE2G1 UBE2G2 UBE2A ITCH UBE2S PSMC4 UBE2T UBE2V2 VALINE BIOSYNTHESIS%PANTHER PATHWAY%P02785 Valine biosynthesis BCAT2 ILVBL BCAT1 VASOPRESSIN SYNTHESIS%PANTHER PATHWAY%P04395 Vasopressin synthesis AVP SEC11A PAM SEC11C SPCS3 SPCS2 PREPL NHLRC3 PREP CPE OXT VEGF SIGNALING PATHWAY%PANTHER PATHWAY%P00056 VEGF signaling pathway PRR5 ARHGAP8 TGFB1I1 ARAF ARHGAP1 HSPB1 PIK3CD PIK3CB PIK3C2A ETS1 PIK3CG PIK3C2B CASP9 KDR RAC2 RAC3 AKT1 RAC1 HRAS PRKCG MAP2K1 PRKCI MAP2K2 PRKCH SPHK2 PRKCB PRKCE SPHK1 PRKCD PLA2G4A PRKCA MAPKAPK3 PIK3CA PRKD3 MAPKAPK2 PRKCQ PIK3C3 PRKD2 PRKD1 CRYAA RAF1 CRYAB SHC2 SH2D2A PXN PIK3R3 PIK3R2 PIK3R1 HIF1A PRKCZ NRAS PLCG2 LPXN MAPK1 PLCG1 MAPK3 NOS3 BRAF MAPK14 PTK2 VEGFA VITAMIN B6 BIOSYNTHESIS%PANTHER PATHWAY%P02786 Vitamin B6 biosynthesis VITAMIN B6 METABOLISM%PANTHER PATHWAY%P02787 Vitamin B6 metabolism PDXK PSAT1 PNPO VITAMIN D METABOLISM AND PATHWAY%PANTHER PATHWAY%P04396 Vitamin D metabolism and pathway F13B GC CYP27A1 CYP27B1 CYP27C1 RXRA VDR RARA WNT SIGNALING PATHWAY%PANTHER PATHWAY%P00057 Wnt signaling pathway PCDHGC3 CSNK1A1L SMARCAL1 SMARCB1 FZD10 ARR3 BTRC CER1 PRKCG PRKCI SMARCC1 SMARCC2 PRKCH PRKCB PRKCE CSNK2A3 PRKCD CSNK2A2 PRKCA CSNK1D CSNK1E SFRP4 SFRP1 SFRP2 SFRP5 CSNK2B PRKCQ SRCAP CTBP2 PCDH10 CTBP1 PCDH15 PCDH12 NLK PCDH19 PRKCZ PCDH18 PPP3R1 GNG10 PPP3R2 PCDHA1 HLTF PCDHA5 PCDHA4 PCDHA3 PCDHA2 PCDHA9 PCDHA8 PCDHA7 PCDHA6 FZD1 WNT10B WNT10A FZD3 CREBBP FZD2 FZD5 FZD4 PCDH20 SIAH2 FZD7 FZD6 SIAH1 SMARCA5 FZD9 NFATC3 FZD8 NFATC2 NFATC1 INO80 GNG12 SMARCA1 SMARCA2 GNG13 SMARCA4 NFATC4 PCDHGA10 PCDHGA11 PCDHGA12 PCDHB2 PCDHB1 PCDHB6 FAT1 PCDHB5 FAT2 FAT3 PCDHB4 DCHS1 PCDHB3 PCDHB8 PCDHB7 PPP3CA PPP3CB PPP3CC ANKRD6 HELLS KREMEN1 WNT9B KREMEN2 WNT9A AES PLCB3 PLCB4 PLCB1 PLCB2 WNT8A WNT8B FSTL1 NKD1 NKD2 PPP2CA PPP2CB FRZB TBL1Y CTNNA1 CTNNA3 TBL1X CTNNA2 CSNK1A1 WNT7B PCDHB15 PCDHB14 WNT7A PCDHB13 PCDHB12 PCDHB11 PCDHB10 PCDHB16 CTNNB1 PCDH11Y PCDH11X MAP3K7CL CELSR1 CELSR2 CDH9 CDH8 CELSR3 CDH7 CDH6 CDH5 CDH4 CDH3 CDH2 CDH1 EP300 MAP3K7 PCDHAC2 PCDHAC1 TLE4 TLE3 CSNK1G3 TLE2 TLE1 WNT5B FBXW11 WNT5A CHD1L PCDHA13 PCDHA12 PCDHA11 TLE6 PCDHA10 PYGO1 PYGO2 TBL1XR1 CSNK1G2 ITPR1 ITPR2 ITPR3 WNT6 CDH20 DVL1 CDH22 DVL2 CDH23 EP400 DVL3 CDH24 WNT1 WNT2 WNT3 WNT4 SMAD1 SMAD4 WNT3A SMAD5 BCL9 GNAQ GNB2 GNB1 GNB4 GNB3 BMPR1B BMPR1A GSK3B PCDHGB7 PCDHGB6 WNT2B PCDHGB4 PCDHGB2 ARRB1 ARRB2 PPP2R5E DACT1 PCDHGA8 PCDHGA7 PCDHGA6 PCDHGA5 PCDHGA3 PCDHGA2 PCDHGA1 AXIN1 PPP2R5B PPP2R5A PPP2R5D PPP2R5C ARID1A WNT16 TGFBR1 CDH10 CDHR1 CDHR2 CDH11 PCDHGB1 SAG CDH12 CDH13 CDH15 CDH16 CDH17 CDH18 CDH19 SMARCD1 SMARCD2 HDAC2 SMARCD3 HDAC3 HDAC1 LEF1 LRP5 ACVR1B HDAC8 LRP6 GNA14 GNA15 GNG3 ACVR1C GNG2 WNT11 GNG5 GNG4 GNG7 GNA11 GNG8 PCDH1 CTNNAL1 SMARCE1 TCF7L2 TCF7L1 PCDH9 PCDHGC5 PCDH7 PCDHGC4 PCDH8 XANTHINE AND GUANINE SALVAGE PATHWAY%PANTHER PATHWAY%P02788 Xanthine and guanine salvage pathway PNP GDA HPRT1 PRTFDC1 DOPAMINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 72%212676 Dopamine Neurotransmitter Release Cycle CASK LIN7A SYN3 LIN7C CPLX1 LIN7B SYN1 RIMS1 BZRAP1 PPFIA1 APBA1 PPFIA4 STX1A SLC18A2 VAMP2 PPFIA3 PPFIA2 UNC13B SNAP25 RAB3A SYT1 GLYCEROPHOSPHOLIPID BIOSYNTHESIS%REACTOME%R-HSA-1483206.4 Glycerophospholipid biosynthesis LPGAT1 PITPNB CPNE7 CPNE6 LCLAT1 PLB1 LIPI LIPH CPNE1 CPNE3 MFSD2A DGAT2 PCYT2 CSNK2A1 DGAT1 STARD7 CSNK2A2 HRASLS2 PISD PLA2G15 GNPAT PLA2G16 PHOSPHO1 GPD2 PLA2G10 GPD1 CSNK2B PLBD1 HRASLS5 PLA2R1 PLA1A CDS1 ABHD4 ABHD3 CHAT PLA2G3 PLD4 PLD6 PLA2G5 PLD1 PLA2G6 PLD3 PLD2 PGS1 PTDSS2 PTDSS1 PTPMT1 OSBPL8 TMEM86B CHKB OSBPL5 CHKA RARRES3 STARD10 EPT1 DGAT2L6 CRLS1 PEMT ALPI CDS2 SLC44A5 ACHE SLC44A3 SLC44A4 SLC44A1 SLC44A2 LPCAT1 PCTP TAZ OSBPL10 ACP6 FAM73A FAM73B PLA2G12A PLA2G4F PCYT1B PCYT1A PLA2G4D PLA2G4B PLA2G4C PLA2G4A GPCPD1 HADHB HADHA PITPNM1 PITPNM3 PITPNM2 MGLL AGPAT5 AGPAT6 AGPAT9 PLA2G1B AGPAT1 AGPAT2 AGPAT3 AGPAT4 AWAT2 GPAT2 CEPT1 CDIPT PLA2G2F BCHE PLA2G2D PLA2G2E AGK PNPLA8 MBOAT7 PLA2G2A DDHD2 MBOAT1 MBOAT2 DDHD1 ETNPPL GPAM LPCAT4 ETNK2 LPCAT3 ETNK1 LPCAT2 PNPLA3 CHPT1 GPD1L LPIN1 LPIN2 LPIN3 PNPLA2 PHOSPHORYLATION OF THE APC C%REACTOME%R-HSA-176412.3 Phosphorylation of the APC C ANAPC15 ANAPC16 ANAPC7 UBE2C PLK1 UBE2E1 UBE2D1 ANAPC10 ANAPC11 CCNB1 CDC23 CDC26 CDC27 CDC16 CDK1 ANAPC4 ANAPC5 ANAPC1 ANAPC2 GLUCOSE METABOLISM%REACTOME DATABASE ID RELEASE 72%70326 Glucose metabolism SLC25A1 GPI NUP107 NUP188 ADPGK ENO1 ENO2 ENO3 HK2 HK1 HK3 PPP2R1B PPP2R1A PRKACG NUP62 PRKACA PRKACB NDC1 NUP214 SEC13 TPI1 G6PC NUP133 NUP210 PGAM1 PGAM2 PPP2R5D BPGM PGM2L1 NUP93 NUP50 PGP GAPDHS NUP54 ALDOC SLC25A10 ALDOB SLC25A12 ALDOA SLC25A11 GAPDH FBP1 FBP2 SLC25A13 PFKFB2 PFKFB1 POM121 NUP205 PFKFB4 PFKFB3 AAAS NUP160 PPP2CA PPP2CB NUP85 TPR PGK1 NUP88 NUP43 PGK2 PCK1 RAE1 PCK2 RANBP2 GCKR SLC37A1 NUP155 MDH1 GOT1 MDH2 GOT2 NUP153 GCK G6PC2 PFKL G6PC3 GNPDA1 PC GNPDA2 NUP35 NUPL2 PFKM PFKP NUP37 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION)%REACTOME DATABASE ID RELEASE 72%198725 Nuclear Events (kinase and transcription factor activation) PPP2R1B ATF1 PPP2R1A SH3GL3 ATF2 NAB1 NAB2 CHD4 ELK1 RPS6KA3 LYL1 RPS6KA5 RPS6KA2 RPS6KA1 EP300 JUNB DUSP4 PPP2R5D MEF2A MEF2C DUSP3 TCF12 FOS VRK3 F3 DUSP6 DNM2 DUSP7 ARC CREB1 VGF MAPKAPK2 SGK1 TRIB1 TPH1 RRAD SRF ASCL1 MAPK7 MAPK1 MEF2D MAPK3 EGR1 PPP2CA EGR2 PPP2CB JUND EGR3 EGR4 MAPK14 FOSL1 MAPK11 REST CDK5 ID2 ID1 ID4 FOSB ID3 CDK5R2 CDK5R1 CONJUGATION OF PHENYLACETATE WITH GLUTAMINE%REACTOME%R-HSA-177162.1 Conjugation of phenylacetate with glutamine ACSM1 ACSM2B DRUG RESISTANCE IN ERBB2 KD MUTANTS%REACTOME DATABASE ID RELEASE 72%9665230 Drug resistance in ERBB2 KD mutants ERBB2IP HSP90AA1 CDC37 ERBB2 VPR-MEDIATED INDUCTION OF APOPTOSIS BY MITOCHONDRIAL OUTER MEMBRANE PERMEABILIZATION%REACTOME DATABASE ID RELEASE 72%180897 Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization SLC25A4 SLC25A6 SLC25A5 DERMATAN SULFATE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 72%2022923 Dermatan sulfate biosynthesis NCAN UST DSE BGN CSPG5 CSPG4 CHST14 DCN BCAN VCAN DSEL DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD%REACTOME DATABASE ID RELEASE 72%3359473 Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD MMACHC MMADHC VRNP ASSEMBLY%REACTOME DATABASE ID RELEASE 72%192905 vRNP Assembly HSP90AA1 IPO5 EPIGENETIC REGULATION OF GENE EXPRESSION%REACTOME%R-HSA-212165.2 Epigenetic regulation of gene expression RBBP4 TAF1B TAF1C TDG SAP30L TAF1A TWISTNB POLR2E POLR2F SAP18 POLR2H RBBP7 MTA2 SF3B1 MTA3 POLR2K POLR2L MBD3 SUZ12 MBD2 GTF2H1 DEK GTF2H2 GTF2H3 GTF2H4 GATAD2B GTF2H5 GATAD2A MYBBP1A ERCC3 ERCC2 ERCC6 CCNH EHMT2 ARID4B TTF1 RRP8 ACTB SAP130 HIST1H2AE HIST1H2AD HIST3H2BB HIST1H2AC HIST1H2AB SAP30BP HIST1H2AJ CHD4 CD3EAP SAP30 HIST2H3A HIST1H2BF HIST1H2BE HIST1H2BH EP300 HIST1H2BG HIST2H3D HIST1H2BB HIST1H2BA HIST2H3C HIST1H2BD HIST1H2BC H2AFB1 DNMT1 HIST1H3J BAZ2A HIST1H3A HIST1H3F HIST1H3G HIST1H3H HIST1H3I SUDS3 HIST1H3B HIST1H3C HIST1H3D HIST1H3E H3F3B HIST1H4K CBX3 HIST1H4L H3F3A SMARCA5 H2BFS HIST1H4A CDK7 HIST1H4B HIST1H4H HIST1H4I HIST1H4J HIST1H4C MNAT1 HIST1H4D HIST1H4E PHF19 EZH2 HIST1H4F HIST2H2AA3 GSK3B HIST2H2AA4 PHF1 SUV39H1 CHD3 HIST2H2AC DNMT3L ZNRD1 SIN3B H2AFJ SIN3A UBTF DNMT3B JARID2 TBP EED H2AFZ DNMT3A H2AFX TET2 TET1 H2AFV BAZ1B SIRT1 HIST2H2BE KAT2B KAT2A AEBP2 POLR1A HIST4H4 POLR1B MTF2 TET3 POLR1C POLR1E HIST1H2BN HIST1H2BM HDAC2 HIST1H2BO HIST1H2BJ HDAC1 UHRF1 HIST1H2BI HIST1H2BL HIST1H2BK DDX21 HIST2H4A TAF1D HIST2H4B MTA1 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS%REACTOME%R-HSA-450531.4 Regulation of mRNA stability by proteins that bind AU-rich elements PSMD3 AKT1 PSMD1 TNPO1 DIS3 PRKCD PRKCA YWHAZ PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 XRN1 PSMA2 PSME3 PSME4 PSME1 PSME2 PABPC1 UBA52 DCP2 PSMD10 PSMB11 PSMD12 SET PSMD11 PSMD14 ANP32A PSMD13 NUP214 PARN PSMA7 PSMB10 PSMA8 ZFP36L1 EXOSC7 PSMB6 EXOSC6 PSMB7 EXOSC5 PSMB4 EXOSC4 PSMB5 PSMB2 UBB PSMB3 EXOSC9 EXOSC8 UBC PSMB1 PSMF1 EXOSC3 MAPKAPK2 RPS27A EXOSC2 EXOSC1 HSPA8 SHFM1 TNFSF13 PSMB8 PSMB9 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 DCP1A EIF4G1 MAPK14 MAPK11 YWHAB HSPB1 ELAVL1 PSMD8 PSMD9 PSMD6 XPO1 PSMD7 PSMD4 PSMD5 PSMD2 KHSRP HEDGEHOG 'OFF' STATE%REACTOME%R-HSA-5610787.1 Hedgehog 'off' state INTU CUL1 PRKAR2B KIF3A PRKAR2A TTC21B PTCH1 IFT122 FUZ ADCY10 GNAS MKS1 GLI1 GLI3 GLI2 IFT52 SUFU IFT57 OFD1 IFT140 KIF7 WDR35 NUMB ADCY4 ADCY3 PRKACG TULP3 ADCY2 PRKACA ADCY1 PRKACB ADCY8 ADCY7 ADCY6 ADCY5 CSNK1A1 WDR19 ITCH PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 UBA52 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 UBB PSMB3 UBC PSMB1 PSMF1 RPS27A SHFM1 PSMB8 PSMB9 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 GSK3B IFT172 BTRC SKP1 DYNC2H1 RPGRIP1L RBX1 IFT88 ADCY9 PRKAR1B SMO PRKAR1A GPR161 HYDROXYCARBOXYLIC ACID-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 72%3296197 Hydroxycarboxylic acid-binding receptors HCAR2 HCAR3 HCAR1 ABORTIVE ELONGATION OF HIV-1 TRANSCRIPT IN THE ABSENCE OF TAT%REACTOME DATABASE ID RELEASE 72%167242 Abortive elongation of HIV-1 transcript in the absence of Tat GTF2F1 GTF2F2 POLR2A POLR2B POLR2C POLR2D POLR2G POLR2E NELFB POLR2F NELFA NELFCD POLR2H POLR2I POLR2J NELFE POLR2K POLR2L CTDP1 NCBP1 NCBP2 SUPT4H1 SUPT5H REGULATION OF RAS BY GAPS%REACTOME%R-HSA-5658442.1 Regulation of RAS by GAPs PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 UBA52 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 UBB PSMB3 UBC PSMB1 PSMF1 RPS27A SHFM1 PSMB8 PSMB9 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 SPRED3 SPRED2 SPRED1 SYNGAP1 HRAS RASA3 RASA4 RASA1 RASA2 CUL3 RASAL1 RASAL2 RASAL3 NRAS DAB2IP NF1 KBTBD7 PSMD8 PSMD9 PSMD6 RBX1 PSMD7 PSMD4 PSMD5 PSMD2 ALTERNATIVE COMPLEMENT ACTIVATION%REACTOME%R-HSA-173736.2 Alternative complement activation CFD C3 GZMM CFB EXPRESSION AND PROCESSING OF NEUROTROPHINS%REACTOME%R-HSA-9036866.2 Expression and Processing of Neurotrophins FURIN PCSK6 NGF PCSK5 MITOCHONDRIAL FATTY ACID BETA-OXIDATION%REACTOME DATABASE ID RELEASE 72%77289 Mitochondrial Fatty Acid Beta-Oxidation ACSF2 PCCA PCCB NDUFAB1 ACOT2 ACOT1 PCTP ACADVL HADHB ECHS1 HADHA ACAA2 ACSM3 ECI1 ACSM6 DBI MCEE ACADL THEM5 THEM4 ACADM ACAD11 HADH ACADS ACAD10 DECR1 ACBD7 ACBD6 ACOT9 MECR ACOT7 MMAA ACOT11 ACOT12 ACOT13 MUT MCAT SIGNALING BY LIGAND-RESPONSIVE EGFR VARIANTS IN CANCER%REACTOME%R-HSA-5637815.1 Signaling by Ligand-Responsive EGFR Variants in Cancer HRAS NRAS UBB EGF SHC1 UBC GAB1 PIK3R1 CBL EGFR RPS27A UBA52 PIK3CA PLCG1 SOS1 HSP90AA1 CDC37 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION)%REACTOME%R-HSA-2173791.1 TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) TGFB1 SMURF1 ARHGEF18 CGN F11R PRKCZ TGFBR1 RHOA TGFBR2 UBB FKBP1A PARD6A PARD3 UBC RPS27A UBA52 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE%REACTOME DATABASE ID RELEASE 72%174414 Processive synthesis on the C-strand of the telomere LIG1 RPA1 RPA2 POLD3 POLD4 WRN RPA3 POLD1 POLD2 DNA2 FEN1 BLM PCNA FGFR1 LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 72%190242 FGFR1 ligand binding and activation FGF6 FGF9 ANOS1 FGF20 FGF1 FGF2 FGF23 FGF3 FGF22 FGF10 FGF4 VEGFA-VEGFR2 PATHWAY%REACTOME DATABASE ID RELEASE 72%4420097 VEGFA-VEGFR2 Pathway PDPK1 AKT1 SPHK1 CYBB CYBA VAV1 PRKCD VAV2 PRKCA MAPKAPK3 ELMO1 ELMO2 TRIB3 CRK DOCK1 SHC2 ROCK1 ROCK2 MAPKAP1 SH2D2A PXN ITPR1 ITPR2 ITPR3 PIK3R2 CDC42 PAK1 CTNNA1 PRKACG PTK2B RICTOR PRKACA NCKAP1L PRKACB FYN WASF1 PAK3 WASF2 PAK2 WASF3 JUP NOS3 CAV1 BAIAP2 MTOR PTK2 MAPK12 MAPK13 ABI2 AXL ABI1 CTNNB1 THEM4 BCAR1 MAPKAPK2 MAPK14 MAPK11 PIK3R1 PIK3CA PLCG1 HSP90AA1 HRAS RASA1 PRR5 CYFIP2 PRKCZ CYFIP1 NCKAP1 RHOA AHCYL1 NRAS NCF1 NCF2 ITGB3 NCF4 CTNND1 BRK1 PIK3CB SHB HSPB1 CDH5 AKT2 AKT3 MLST8 KDR NCK2 ITGAV RAC1 NCK1 VAV3 PRKCB REUPTAKE OF GABA%REACTOME DATABASE ID RELEASE 72%888593 Reuptake of GABA SLC6A13 SLC6A12 SLC6A11 SLC6A1 VITAMINS%REACTOME%R-HSA-211916.1 Vitamins CYP24A1 CYP26C1 CYP2R1 CYP26A1 CYP27B1 CYP26B1 TOXICITY OF BOTULINUM TOXIN TYPE G (BONT G)%REACTOME%R-HSA-5250989.1 Toxicity of botulinum toxin type G (BoNT G) VAMP1 VAMP2 SYT1 REGULATION BY C-FLIP%REACTOME DATABASE ID RELEASE 72%3371378 Regulation by c-FLIP TRADD TNFSF10 FAS TNFRSF10B FASLG RIPK1 TNFRSF10A TRAF2 FADD CASP8 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE%REACTOME DATABASE ID RELEASE 72%532668 N-glycan trimming in the ER and Calnexin Calreticulin cycle RNF139 PSMC1 OS9 MLEC UGGT2 UGGT1 PDIA3 EDEM3 EDEM1 AMFR EDEM2 SYVN1 MOGS MARCH6 RAD23B RNF103 CANX TRIM13 CALR MAN1B1 RNF185 UBA52 ENGASE UBB UBC RPS27A VCP UBXN1 PRKCSH NGLY1 SEL1L DERL1 DERL2 RNF5 GANAB NTF3 ACTIVATES NTRK2 (TRKB) SIGNALING%REACTOME DATABASE ID RELEASE 72%9025046 NTF3 activates NTRK2 (TRKB) signaling NTRK2 NTF3 TRANSCRIPTIONAL REGULATION BY TP53%REACTOME DATABASE ID RELEASE 72%3700989 Transcriptional Regulation by TP53 EXO1 CASP1 CASP2 TCEB3C TOPBP1 TCEB3B YWHAG ZNF385A YWHAH RFC5 GPX2 RFC3 RFC4 APAF1 RFC2 PPP2R5C RABGGTB RABGGTA RBL2 CCNA2 CCNA1 TFDP1 RBL1 TFDP2 RRM2B BIRC5 TMEM219 TMEM55B PRKAA1 RNF34 PRKAA2 CSNK2A1 GLS2 TAF9 TAF1L CSNK2A2 NLRC4 AURKB AURKA TP53INP1 E2F1 RBBP8 E2F4 RFFL E2F7 E2F8 CSNK2B TAF15 TAF12 TAF13 NDUFA4 TAF10 TXNRD1 TAF11 ARID3A SSRP1 PML TNRC6C RAD50 CARM1 RQCD1 BAX CTDP1 TAF7 TAF6 TAF5 SUPT4H1 TAF4 SUPT5H TAF3 GTF2F1 TAF2 GTF2F2 TNRC6A POLR2A TNRC6B POLR2B TAF1 POLR2C POLR2D POLR2G NELFB NELFA NELFCD POLR2I POLR2J NELFE CCNH EHMT2 CCNB1 CDK1 CDK7 MNAT1 CHD3 TBP HDAC2 HDAC1 BLM PCNA RBBP4 RPA1 RPA2 WRN RPA3 POLR2E POLR2F DNA2 POLR2H RBBP7 MTA2 GPI POLR2K POLR2L MBD3 GTF2H1 GTF2H2 PPP2R1B GTF2H3 PPP2R1A GTF2H4 GATAD2B GTF2H5 GATAD2A ERCC3 ERCC2 MDC1 CCNK TP53RK MT-CO1 EHMT1 NOC2L GLS TP53AIP1 KAT5 CHEK2 CHEK1 PIP4K2A PIP4K2B PIP4K2C TP63 DAXX PRKAB2 HUS1 PPP2CA PRKAB1 PPP2CB RRAGA COX7A2L SCO1 RRAGC SCO2 RRAGB DDIT4 RRAGD MT-CO2 MT-CO3 TP53 RHNO1 L3MBTL1 MEAF6 TXN PRDX2 NUAK1 BRIP1 PCBP4 PRDX1 TP53BP2 SFN ATRIP BANP BARD1 PLK3 JUN PRELID1 SURF1 CREBBP CRADD GADD45A PLK2 TPX2 MOV10 AGO3 AGO4 AGO1 AGO2 PRR5 RAD17 ATM CDK12 CDK13 TP73 ATR CDKN1A BTG2 COX7B CDKN1B ELL SETD8 YWHAB SETD9 AKT2 PHF20 AKT3 PRKAG1 CHM MLST8 PRKAG2 BRCA1 COX7C PRKAG3 BBC3 TAF7L RPTOR ING5 PDPK1 AKT1 ING2 AIFM2 CASP10 TNKS1BP1 COX8A PRMT5 BRD1 YWHAZ RMI2 CNOT6L PRMT1 RMI1 TOP3A DDB2 RAD51D MAPKAP1 TCEB3CL2 COX5B COX5A PLAGL1 PERP UBA52 TCEB3 PMS2 TCEB2 TCEB1 TCEB3CL TAF9B ATF2 RICTOR BID BRD7 TIGAR NPM1 CHD4 CDKN2A MRE11A COX6C MLH1 HIPK1 POU4F1 LRPPRC EP300 POU4F2 HIPK2 MTOR TTC5 CENPJ CCNG1 TCEA1 FOS LAMTOR2 RAD1 UBB LAMTOR1 LAMTOR4 LAMTOR3 LAMTOR5 UBC STEAP3 CCNT2 CCNT1 RPS27A TACO1 SGK1 PRDM1 COX6A1 STK11 SESN3 SESN2 NBN BNIP3L G6PD SUPT16H USP7 IGFBP3 USP2 TSC2 TSC1 CDC25C COX6B1 MAPK14 MSH2 CCNE2 MAPK11 FANCD2 CCNE1 CDK5 KAT6A MAPKAPK5 COX16 COX18 AK6 NDRG1 CDK5R1 SMYD2 COX11 PMAIP1 FAS COX14 SLC38A9 TNFRSF10B BCL2L14 MAP2K6 ZNF420 TNFRSF10A FANCI SLMO1 BRPF1 BRPF3 TNFRSF10C FANCC CNOT10 TNFRSF10D CNOT4 CDK9 CNOT6 CNOT7 RGCC TP53I3 BCL6 CNOT11 CNOT1 RHEB CNOT2 CNOT3 JMY CDK2 MDM2 TAF4B CYCS PIN1 MDM4 CNOT8 RAD9B COX20 RAD9A YWHAE DYRK2 PPP1R13B COX4I1 PTEN TRIAP1 PIDD1 YWHAQ CASP6 PPP1R13L PROTEIN FOLDING%REACTOME%R-HSA-391251.1 Protein folding CSNK2A1 CSNK2A2 CSNK2B GAPDHS TP53 SPHK1 ACTB DCAF7 CCT6B TUBB6 GNAT2 TUBB3 GNAT3 TUBB1 FBXO4 LONP2 FBXO6 GNAT1 RGS9 RGS6 RGS7 FBXW4 FBXW5 FBXW10 FBXW7 FBXW9 TUBA4B FBXW2 TUBA4A XRN2 FKBP9 GNAZ ARL2 GNG10 TBCD TBCC TBCB TBCA GNG12 GNG11 GNG13 GNAO1 CCT6A GNB2 TBCE CCNE2 GNB1 GNB4 CCNE1 PDCL GNB3 SKIV2L FBXL3 GNB5 FBXL5 TUBA8 WRAP53 GNGT1 TUBA1C TUBA1B GNGT2 TUBA1A KIF13A CCT3 CCT2 VBP1 TUBB2B TUBB2A TCP1 PFDN1 PFDN2 PFDN4 PFDN5 PFDN6 HDAC3 TUBAL3 USP11 GBA GNAI3 GNAI1 GNAI2 AP3M1 TUBA3E GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 CCT8 CCT7 CCT5 CCT4 NOP56 ARFGEF2 STAT3 TUBB4B TUBB4A RGS11 TRANSCRIPTION OF THE HIV GENOME%REACTOME%R-HSA-167172.2 Transcription of the HIV genome GTF2B GTF2A1 TCEB3C GTF2A2 RNMT TCEB3B GTF2E1 GTF2E2 POLR2E RNGTT POLR2F POLR2H TCEB3CL2 POLR2K CCNH POLR2L TCEB3 GTF2H1 TCEB2 GTF2H2 TCEB1 GTF2H3 TCEB3CL GTF2H4 TAF9B GTF2H5 ERCC3 ERCC2 TAF9 TAF1L TCEA1 TAF15 TAF12 TAF13 CCNK TAF10 CCNT2 TAF11 CCNT1 SSRP1 CTDP1 TAF7 NCBP1 TAF6 SUPT16H NCBP2 TAF5 SUPT4H1 TAF4 SUPT5H TAF3 GTF2F1 TAF2 GTF2F2 CDK7 POLR2A POLR2B TAF1 POLR2C POLR2D POLR2G NELFB MNAT1 NELFA NELFCD POLR2I POLR2J NELFE AK6 TBP CDK9 TAF4B ELL TAF7L INTESTINAL SACCHARIDASE DEFICIENCIES%REACTOME%R-HSA-5659898.2 Intestinal saccharidase deficiencies SI LCT INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS%REACTOME%R-HSA-176033.2 Interactions of Vpr with host cellular proteins NUP85 TPR NUP88 NUP43 RAE1 RANBP2 NUP107 NUP155 NUP188 PSIP1 BANF1 KPNA1 HMGA1 NUP153 NUP62 NUP35 NUPL2 NDC1 NUP214 SEC13 SLC25A5 NUP37 SLC25A4 SLC25A6 NUP133 NUP210 NUP93 NUP50 NUP54 POM121 NUP205 AAAS NUP160 DEFECTIVE RHAG CAUSES REGULATOR TYPE RH-NULL HEMOLYTIC ANEMIA (RHN)%REACTOME DATABASE ID RELEASE 72%5619042 Defective RHAG causes regulator type Rh-null hemolytic anemia (RHN) RHAG CYTOSOLIC TRNA AMINOACYLATION%REACTOME%R-HSA-379716.1 Cytosolic tRNA aminoacylation HARS IARS FARSA EEF1E1 FARSB AARS CARS YARS DARS WARS VARS SARS TARS EPRS AIMP1 NARS AIMP2 KARS QARS LARS PPA1 RARS MARS GARS PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME DATABASE ID RELEASE 72%622323 Presynaptic nicotinic acetylcholine receptors CHRNA1 CHRNB2 CHRND CHRNB4 CHRNA3 CHRNB3 CHRNA2 CHRNA5 CHRNG CHRNA4 CHRNE CHRNA6 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2%REACTOME DATABASE ID RELEASE 72%5140745 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 FZD2 FZD5 WNT5A CLTC CLTB CLTA AP2A1 AP2B1 AP2A2 AP2S1 ROR1 ROR2 AP2M1 SUMO IS CONJUGATED TO E1 (UBA2:SAE1)%REACTOME%R-HSA-3065676.2 SUMO is conjugated to E1 (UBA2:SAE1) SUMO2 UBA2 SAE1 SUMO1 SUMO3 RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN BCR SIGNALING%REACTOME%R-HSA-8939245.1 RUNX1 regulates transcription of genes involved in BCR signaling BLK ELF1 ELF2 CBFB PAX5 RUNX1 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT%REACTOME%R-HSA-159236.3 Transport of Mature mRNA derived from an Intron-Containing Transcript NUP107 NUP188 NUP62 NDC1 NUP214 SEC13 NUP133 NUP210 NUP93 NUP50 NUP54 POM121 NUP205 NCBP1 NXT1 NCBP2 EIF4A3 AAAS CASC3 NUP160 GLE1 MAGOH THOC1 NUP85 THOC3 TPR THOC2 THOC5 NUP88 THOC7 NUP43 CDC40 THOC6 SRRM1 RAE1 DDX39A DDX39B RANBP2 ZC3H11A SARNP SRSF2 NUP155 SRSF3 SRSF4 SRSF5 SRSF6 SRSF7 NUP153 SLU7 SRSF9 FYTTD1 LUZP4 RBM8A POLDIP3 SRSF1 U2AF1 NUP35 U2AF1L4 NUPL2 NXF1 NXF2 U2AF2 NUP37 DHX38 SRSF11 CHTOP UPF3B MAGOHB NXF2B RNPS1 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY%REACTOME DATABASE ID RELEASE 72%399721 Glutamate binding, activation of AMPA receptors and synaptic plasticity GRIA2 CAMK2D CAMK2A AKAP5 GRIP1 CACNG8 EPB41L1 PRKCA TSPAN7 MYO6 CACNG2 CAMK2G CACNG3 GRIA3 CACNG4 GRIA4 PRKCG NSF DLG1 DLG4 PICK1 MDM2 AP2A1 GRIA1 CAMK2B PRKCB REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION%REACTOME DATABASE ID RELEASE 72%2565942 Regulation of PLK1 Activity at G2 M Transition HAUS7 CUL1 CEP70 PRKAR2B CEP72 CEP192 PCNT CEP76 YWHAG CLASP1 CEP78 PLK4 DYNC1H1 ODF2 CEP152 NDE1 NEDD1 FGFR1OP CEP41 OFD1 UBA52 PPP2R1A PRKACA AURKA PLK1 CENPJ CCNB1 UBB UBC CDK1 RPS27A TUBA4A CEP57 CETN2 TUBA1A CEP164 CCP110 PPP1CB ACTR1A PCM1 HSP90AA1 CNTRL CEP250 NEK2 NINL CEP290 RAB8A CDK5RAP2 CEP135 BORA PPP1R12A FBXW11 TUBB CEP131 HAUS4 HAUS3 HAUS6 CSNK1D HAUS5 CSNK1E TUBG1 DYNLL1 CKAP5 HAUS2 HAUS1 AKAP9 CEP63 MAPRE1 BTRC AJUBA YWHAE SKP1 SFI1 OPTN TUBB4B PAFAH1B1 TUBB4A SDCCAG8 DYNC1I2 DCTN2 SSNA1 DCTN3 CCNB2 HAUS8 PREVENTION OF PHAGOSOMAL-LYSOSOMAL FUSION%REACTOME DATABASE ID RELEASE 72%9636383 Prevention of phagosomal-lysosomal fusion UBC RPS27A UBA52 HGS VPS33B RAB5A CORO1A RAB7A UBB SHC-MEDIATED CASCADE:FGFR1%REACTOME%R-HSA-5654688.1 SHC-mediated cascade:FGFR1 HRAS NRAS FGF6 FGF9 SOS1 FGF20 FGF1 FGF2 FGF23 FGF3 FGF22 FGF10 FGF4 METABOLISM%REACTOME DATABASE ID RELEASE 72%1430728 Metabolism ATP5G2 ATP5G1 HS2ST1 PRKAR2B RPS4X DBT PRKAR2A CYP3A43 RPS3A ATP5F1 PRODH2 DCK GNAS LSS DDAH1 DCT THRAP3 DDAH2 ALDH1A1 RBKS VAC14 PDXK DDC ETFDH DDO GNA14 ADCY4 GNA15 ADCY3 UGP2 CHSY1 ADCY2 ALDH1B1 ADCY1 FAM120B ADCY8 GNA11 ADCY7 PDSS2 ADCY6 PDSS1 ADCY5 CHSY3 LUM MT-ND6 MT-ND4 MT-ND5 MT-ND2 MT-ND3 MT-ND1 LIPE IL4I1 AS3MT NSDHL TDO2 CYP2D6 LRAT XYLB STARD3 STARD4 STARD5 STARD6 HSPG2 UPB1 HDHD1 RUFY1 SLC5A6 RBP4 SLC5A8 RBP2 ETHE1 RBP1 UQCRC1 CYP2E1 UQCRC2 IDO2 HPD IDO1 MTMR1 MTMR2 HACD1 MTMR3 ABCB1 HS3ST3A1 RETSAT ABCB7 ABCB4 MTMR8 MTMR9 IQGAP1 MTMR4 HACD3 HACD2 OAZ1 MTMR6 OAZ2 MTMR7 HACD4 OAZ3 SLC5A5 HSD11B1 HSD11B2 UGT8 CYP2B6 CYB5R3 HAO1 PPARGC1A HAO2 PPARGC1B GPIHBP1 ABCA1 GLYATL3 B3GALNT1 GLYATL2 GLYATL1 CS CYP2C9 BHMT CYP2C8 UCK2 UCK1 NOSTRIN ARF3 ARF1 RPLP1 HEXB QPRT HEXA RPLP0 ECSIT AACS TRMT112 B3GALT2 B3GALT1 RPLP2 ELOVL1 LYPLA1 ARG2 ELOVL4 ELOVL5 ARG1 ELOVL2 ELOVL3 ELOVL6 ELOVL7 PTGR1 PTGR2 SUMF2 SUMF1 BDH2 BDH1 ADSSL1 DLD FH IDUA UCP1 RPS27L PTGS2 PTGS1 UCP3 HAS1 UCP2 CARNS1 HAS3 HAS2 GC CYP2F1 SLC16A1 GK AADAT FABP9 FABP1 FABP2 FABP3 FABP4 FABP5 ACADVL ECHS1 LYRM4 AADAC ACAA2 FABP6 ACSM3 ECI1 FABP7 RPL22L1 ACSM6 DBI UGT1A10 MCEE PECR RORA ACADL HNMT THEM5 SAT1 THEM4 HPGDS ACADM OSBP ACAD11 HADH SLC16A8 SLC16A3 ACADS SLC25A44 ACAD10 DECR1 EPM2A PIPOX ACBD7 KPNB1 ACBD6 CYP19A1 ACOT9 ACAT2 MECR ACAT1 ACOT7 SLC9A1 MMAA ACOT11 SLCO1B1 ACOT12 SLCO1B3 ACOT13 PMVK HACL1 MUT MCAT SRD5A2 SRD5A1 ACSF2 PCCA SRD5A3 PCCB B3GALT4 NDUFAB1 B3GALT6 B3GALT5 ACOT2 GGCT ACOT1 MLXIPL SLCO1A2 HSP90AB1 SLC25A2 FHL2 PIK3CD SQRDL PIK3CG NADK2 ME1 ME3 UPP2 ME2 PIK3R1 UPP1 NDUFC2 ARNT PIK3CA NDUFC1 PLCG1 SLC25A16 SLC25A15 CYP2A7 CYP2A6 SLC25A17 SLC25A19 PIK3C3 SLC25A14 ST6GALNAC6 NDUFB9 NDUFB8 SEC23A NDUFB7 LRP1 NDUFB6 PPM1L NDUFB5 NDUFB4 NDUFB3 NDUFB2 HSD17B14 NDUFB1 HSD17B13 LRP2 PPM1K HSD17B12 HSD17B11 LRP8 HSD17B10 SLC25A27 CKMT2 SLC25A28 SLC25A21 D2HGDH PCBD1 SLC25A20 C9orf41 NDUFA9 CYB5B CYB5A NDUFA8 NDUFA7 SEC24B NDUFA6 SEC24A NDUFA5 MMAB NDUFA3 POLD1 NDUFA2 NDUFA1 RPL23A AKR7L DHODH SLC25A37 TMLHE NT5C1A NT5C1B SLC25A32 SEC24D SEC24C CCNC NUBP1 NUBP2 ARSA ENTPD1 ENTPD2 ENTPD3 PHYKPL ENTPD4 ENTPD5 ENTPD6 ENTPD7 ENTPD8 ASRGL1 GCAT PPP1R3C ATP5S GCDH PEX11A PIK3R4 PIK3R3 ATP5J ATP5I ATP5H ATP5O PIK3R6 PIK3R5 ATP5L ATP5B ATP5E ARSJ ATP5D ARSK ARSH ARSI ARSF ARSG ARSD RIMKLA HMGCLL1 ARSE RIMKLB ARSB CTSA ADHFE1 PAICS ACER2 ACER1 TH RPL27A ACER3 RGL1 CTRC MOGAT3 MOGAT2 MOGAT1 TECR AKR1B1 WASL HSCB ARV1 SPTLC1 SPTLC2 SPTLC3 HYAL1 HYAL2 HYAL3 MLX CD38 IDS CD36 AASS NCOA1 VKORC1 ACAD8 NCOA2 STARD3NL NCOA6 NCOA3 ACAD9 AKR1A1 CD44 INPP1 AKR1D1 RXRB RXRA CYP2A13 GPC1 GPC3 AHCYL1 GPC2 GPC5 GPC4 GPC6 AASDHPPT PLEKHA1 GCH1 PIK3CB NUBPL AKR1C1 PLEKHA5 AKR1C3 PLEKHA6 AKR1C2 PLEKHA3 PLEKHA4 AKR1C4 PLEKHA8 PPP1CA ALDH4A1 GLB1L ESYT3 SPHK1 ESYT2 ESYT1 CPOX CYP46A1 GGT1 SBF1 ACAA1 SBF2 TRIB3 MAT1A DPEP2 DPEP1 DPEP3 FUT2 FUT1 ACACB FUT4 ACACA FUT3 ITPR1 FUT6 ITPR2 FUT5 ITPR3 PIK3R2 EBP FUT7 CYP11A1 FUT9 CYC1 NDUFV3 NDUFV2 PRODH NDUFV1 GGT5 FDPS GGT7 GGT6 VDR NOS3 SLC52A2 CAV1 SLC52A3 SLC52A1 QDPR GCLC CPS1 CYP11B2 CYP11B1 GCLM CHD9 ACSM2A MTR DNPH1 GPHN CPT2 UQCRFS1 SULT4A1 BCKDHA SLC6A12 HS3ST3B1 SLC6A11 GLRX5 BCKDHB ABHD14B LMBRD1 NDUFS8 NDUFS7 NDUFS6 CYP26A1 NDUFS5 CPTP CYP27B1 CYP26B1 CHDH NDUFS4 CYP24A1 CYP26C1 NDUFS3 CYP2R1 FAM96B BLVRB NDUFS2 NDUFS1 MVD BLVRA PAOX MVK MAT2B SAMHD1 CYGB INS HMGCL MAT2A MBTPS1 RPIA GLB1 THRSP RAN MBTPS2 RPL26L1 RPL4 PNMT RPL5 RPL30 RPL3 RPL32 RPL31 GLDC RPL34 RPL8 RPL9 RPL6 RPL7 GCSH RPL36 FDXR CYP1B1 PLCE1 RPL35 RPL38 RPL37 RPL39 SULT2A1 CUBN MED1 ACOT8 RPL21 RPL23 GLCE RPL22 MED8 MED9 HOGA1 MED4 MED6 MED7 CLPS FDX1 RPL24 RPL27 NHLRC1 RPL26 HPRT1 RPL29 ACOT6 RPL28 ACOT4 CHST11 CHST12 PNPO PLCG2 SLC19A3 CHST15 CHST13 SLC19A1 SLC19A2 CDK19 RPL41 MTHFR MTHFS RPL3L GLUD1 FA2H SLC6A7 GLUD2 SLC6A8 CYP1A2 CYP1A1 OGDH PLCH1 PLCH2 ADA ADK ADO SERPINA6 PFAS IMPA1 IMPA2 RFK MIOX ITPK1 BAAT ITPKB ITPKC PLCB3 PLCB4 IVD ITPKA PLCB1 PLCB2 OCA2 ASAH1 ASAH2 RPL10 RPL12 RPL11 GPS2 RHD RPS3 RPL14 RPL13 SC5D RPS2 RPL15 RPL18 RPL17 RPL19 AOC3 AOC1 TIMMDC1 AOC2 AGL FMO1 NMNAT3 FMO2 NMNAT2 FMO3 AGT FIG4 NMNAT1 PLCD3 FMOD PLCD4 PLCD1 CHRM3 CHPF AHR FABP12 ABHD10 NAGLU IYD CHP1 GYG2 GYG1 RPS9 RPS7 RPS8 RPS5 RPS6 AIP RPSA CACNB2 CACNB3 RHCE CEMIP FECH GLO1 AK1 ASMT AK2 MRI1 AK4 AK5 ABHD5 CYP4F22 AK7 AK8 AK9 PSAP ESD UGT3A2 UGT3A1 ESRRA ASNS DHCR24 TECRL CYP4F11 CYP4F12 CDK8 ALB SERINC1 DHCR7 SERINC3 SERINC2 SERINC5 SERINC4 GADL1 RPL7A DHFRL1 GM2A AMN GPX1 GPX4 AMT SORD ADRA2C COASY ADRA2A INMT ASPG RPL37A ASPA ACSS3 SMARCD3 ACSS2 RPE TYRP1 RPL36A GLRX ACSS1 KCNJ11 RPL35A PTPN13 ASS1 MARCKS IMPDH1 IMPDH2 CDO1 FOLR2 GLTP FAAH SLC46A1 HPSE2 GDE1 ACSM5 ACSM4 NADSYN1 CHAC2 CHAC1 PTGDS GLUL MCCC2 ACSL1 SACM1L MCCC1 ACSL6 ACSL5 ACSL4 ACSL3 CMBL INPP4A CYP27A1 INPP4B VDAC1 ALDH7A1 PTGES MAOB MAOA MGST3 MGST1 MGST2 INPP5B DGUOK SGPL1 INPP5A INPP5F INPP5D MARC2 INPP5E MARC1 INPP5J INPP5K SCAP NAALAD2 ASL GSTT2B RPL39L TRAP1 CIDEA PARP16 PARP14 ALOX15B ACADSB CIDEC PARP10 AKR1B10 STAR AKR1B15 HILPDA STAB2 PPCDC GYS2 GYS1 GLIPR1 AUH GUK1 NNT TNFAIP8L1 ANKRD1 TNFAIP8L3 TNFAIP8L2 FFAR1 DLAT MANBA NME2 NME3 AMPD1 NME4 AMPD2 AMPD3 NME1 B3GNT7 B3GNT4 B3GNT3 B3GNT2 UMPS ALOX12B UQCR11 UQCR10 ARNTL HRSP12 TBL1X CA12 OLAH NQO1 ARNT2 NQO2 SCD5 FAH LYVE1 FAU CCBL2 CCBL1 CA14 PSPH CA13 OCRL DCTD ALDH3A1 FOLH1 TBL1XR1 CMPK1 ABCG2 ADIPOR1 ADIPOR2 ALDH3B2 ALDH3B1 ACBD5 ACBD4 EPHX2 EPHX1 AZIN2 ACSF3 AZIN1 NMRAL1 MAN2B2 MAN2B1 ABCD4 B4GALT2 B4GALT3 B4GALT1 SLC2A1 SLC2A2 SLC2A3 DHTKD1 SGSH ALDH2 MT-CO1 CA5B PLCZ1 CA5A GLS NAPRT KYNU CYP4V2 AOX1 MAN2C1 PIP4K2A GUSB PIP4K2B ABCD1 PIP4K2C TSHB HIBCH PSTK PRKAB2 ABCC3 ABCC1 PTGIS ABCC2 COX7A2L ABCC8 SCO1 DCXR ABCC5 SCO2 CTPS2 CTPS1 EHHADH LALBA MT-CO2 B4GALT6 MT-CO3 B4GALT7 B4GALT4 B4GALT5 PON3 HPGD TXN PON2 GMPR2 PON1 BRIP1 PRELP LTC4S BPNT1 B3GAT3 B3GAT2 B3GAT1 SGPP2 SGPP1 POMC PIKFYVE SCD SURF1 ALOX5AP CREBBP SCLY COX7B PRKAG2 COX7C COX8A COX5B COX5A COX6C LRPPRC TACO1 COX6A1 STK11 G6PD COX6B1 COX16 COX18 AK6 COX11 COX14 CYCS COX20 COX4I1 PTEN GPX2 RRM2B TMEM55B PRKAA2 GLS2 TAF9 NDUFA4 TXNRD1 CARM1 GNG10 GNG12 GNG11 GNG13 GNB2 GNB1 GNB4 GNB3 GNB5 GNGT1 GNGT2 HDAC3 GBA GNAI1 GNAI2 GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 DARS SARS EPRS AIMP1 AIMP2 KARS QARS LARS PPA1 RARS MARS IARS EEF1E1 SUMO2 AKAP5 PPP1CB RAB5A SNAP25 BZRAP1 STX1A VAMP2 LPGAT1 PITPNB CPNE7 CPNE6 LCLAT1 PLB1 LIPI LIPH CPNE1 CPNE3 MFSD2A DGAT2 PCYT2 CSNK2A1 DGAT1 STARD7 CSNK2A2 HRASLS2 PISD PLA2G15 GNPAT PLA2G16 PHOSPHO1 GPD2 PLA2G10 GPD1 CSNK2B PLBD1 HRASLS5 PLA2R1 PLA1A CDS1 ABHD4 ABHD3 CHAT PLA2G3 PLD4 PLD6 PLA2G5 PLD1 PLA2G6 PLD3 PLD2 PGS1 PTDSS2 PTDSS1 PTPMT1 OSBPL8 TMEM86B CHKB OSBPL5 CHKA RARRES3 STARD10 EPT1 DGAT2L6 CRLS1 PEMT ALPI CDS2 SLC44A5 ACHE SLC44A3 SLC44A4 SLC44A1 SLC44A2 LPCAT1 PCTP TAZ OSBPL10 ACP6 FAM73A FAM73B PLA2G12A PLA2G4F PCYT1B PCYT1A PLA2G4D PLA2G4B PLA2G4C PLA2G4A GPCPD1 HADHB HADHA PITPNM1 PITPNM3 PITPNM2 MGLL AGPAT5 AGPAT6 AGPAT9 PLA2G1B AGPAT1 AGPAT2 AGPAT3 AGPAT4 AWAT2 GPAT2 CEPT1 CDIPT PLA2G2F BCHE PLA2G2D PLA2G2E AGK PNPLA8 MBOAT7 PLA2G2A DDHD2 MBOAT1 MBOAT2 DDHD1 ETNPPL GPAM LPCAT4 ETNK2 LPCAT3 ETNK1 LPCAT2 PNPLA3 CHPT1 GPD1L LPIN1 LPIN2 LPIN3 PNPLA2 ATP5C1 NDST2 NDST1 SCP2 SLC25A1 NDST4 GPI NUP107 NDST3 CKMT1B NUP188 GSTK1 ADPGK SDS ENO1 TSTD1 ENO2 SECISBP2 ENO3 CACNA2D2 HK2 PHKA1 HK1 PHKA2 HK3 CH25H PPP2R1B MTHFD1 PPP2R1A PRKACG MTHFD2 FAR1 NUP62 PRKACA FAR2 PRKACB TMEM126B CLOCK NDC1 SHMT2 NUP214 SAR1B SEC13 SHMT1 TPI1 CIAO1 G6PC SULT1A1 NUP133 HLCS NUP210 RDH11 PGAM1 AGMO PGAM2 AFMID PPP2R5D PIP5K1A BPGM PIP5K1B PGM2L1 LTA4H NUP93 PIP5K1C NUP50 SULT1A4 PGP SULT1A3 GAPDHS SULT1A2 NUP54 GSTM4 ALDOC GSTM3 SLC25A10 GSTM2 ALDOB GSTM1 SLC25A12 CYP4F2 ALDOA CYP4F3 SLC25A11 CYP4F8 GAPDH DHFR FBP1 SULT1B1 FBP2 B4GAT1 SLC25A13 FASN PFKFB2 GSTM5 PFKFB1 LGMN POM121 MTMR10 NUP205 MTMR12 PFKFB4 KCNC2 PFKFB3 MTMR14 AAAS DPYS NUP160 MED19 PPP2CA MED16 PPP2CB MED15 NUP85 MED18 TPR MED17 PGK1 MED12 NUP88 SMPD3 NUP43 MED11 PGK2 SULT1C2 PCK1 SMPD2 RAE1 MED14 PCK2 MED13 RANBP2 ATIC GCKR SMPD4 SLC37A1 MED10 NUP155 SMPD1 MDH1 TSPO GOT1 ENOPH1 MDH2 SULT1C4 GOT2 CHST6 NUP153 CHST7 GCK GSTO2 G6PC2 SPHK2 PFKL GSTO1 G6PC3 MED27 GNPDA1 MED26 PC MED29 GNPDA2 MED28 NUP35 MED23 NUPL2 MED22 PFKM SLC7A5 PFKP MED25 NUP37 MED24 CYP21A2 MED21 MED20 AGPS DPYD CHST1 ACSBG1 PPARG L2HGDH PPARA ACSBG2 CHST5 RAPGEF3 CHST2 PPARD RAPGEF4 CHST3 OAT SAMD8 GSTP1 ATP5A1 ODC1 DLST ABCB11 SULT1E1 KCNB1 CKMT1A BBOX1 CIAPIN1 AGRN CRAT KCNG2 ALDH1L1 SLC27A1 ALDH1L2 NUDT11 FADS2 NUDT10 UROD NUDT19 NUDT16 NUDT15 NUDT13 FADS1 NUDT12 UGT2B10 PIAS4 UGT2B11 ADIPOQ UGT2B15 UGT2B17 APOA1BP TPST2 TPST1 MINPP1 ACLY SMS SLC27A3 SLC27A2 SLC27A5 UQCRB GMPS GMPR GSTT2 GSTT1 NRF1 CYP2C19 CYP2C18 EP300 NPAS2 UQCRH TKFC NDOR1 RAP1A MED30 AMDHD1 MED31 KDSR IP6K1 NADK DNM2 IP6K3 IP6K2 AGXT2 UROS BMX MAPKAPK2 UCKL1 SP1 UQCRQ TPH1 TBXAS1 OGN ACO2 HPSE MT-CYB OSBPL1A ALAS2 ALAS1 APIP ETFA ETFB ALAD SPR ACP5 UGT2A3 PGM2 UGT2A2 PGLS UGT2A1 PGM1 CERS3 CERS4 CERS5 CERS6 IMPAD1 UGT2B4 AGXT ACSM1 BCAT1 ACSM2B DCTPP1 FXN TNFRSF21 UGT2B7 CERS1 CERS2 HSP90AA1 BCAT2 PRPS2 PRPS1 UGT2B28 SRM SRR AWAT1 PHKG1 PHKG2 SLC36A4 MID1IP1 CYP4B1 GSTZ1 SUCLA2 UROC1 NAGS DMGDH SLC23A2 CERK SLC23A1 BCAN NUDT5 VCAN NUDT3 DSEL NUDT4 NCAN HYKK UST STS DSE BGN PPAT BSG CSPG5 CYP3A7-CYP3A51P CSPG4 CTRB2 CHST14 CTRB1 DCN OMD TALDO1 CYP39A1 MMACHC BTD MMADHC PPA2 CES3 CES2 CES1 SLC45A2 SDC4 SDC2 SDC3 NEU2 NEU3 APOM PPCS NEU1 B4GALNT1 APOE APOB DECR2 B4GALNT2 SLC10A1 SLC10A2 MED13L EXT1 BST1 EXT2 ALDH6A1 NDUFAF6 NDUFAF7 NDUFAF4 NDUFAF5 NDUFAF2 SDC1 NDUFAF3 NDUFAF1 LDHAL6A LDHAL6B ACY3 ACY1 HIBADH CROT KHK MT-ATP6 THTPA NMRK2 NMRK1 PHGDH GAA SREBF2 APRT AHCY HSD17B3 FITM1 HSD17B4 FITM2 HSD17B7 HSD17B8 CYP17A1 PDZD11 HSD17B1 ORMDL2 HSD17B2 ORMDL3 XDH PNPLA7 ORMDL1 GCG CYP8B1 MT-ATP8 NUDT7 KCNS3 PNPLA4 PNPLA5 PNPLA6 OTC GDA INPPL1 MSMO1 TXN2 AKR7A2 AKR7A3 PPIP5K1 PPIP5K2 ENPP2 ENPP1 ENPP3 ENPP6 ENPP7 TPTE2 SDHC SDHD SDHA KMO SDHB SHPK SULT6B1 UBIAD1 NNMT NDUFB10 COX15 NDUFB11 CACNA1A CACNA1D GLYAT CACNA1C CACNA1E AANAT DHRS7B MORC2 COX10 EEFSEC SYT5 PDHA2 UBE2I PDHA1 NAT1 NAT2 GNAQ DEGS1 DEGS2 GALK1 TNFAIP8 PODXL2 TAT CYP4A22 ADAL ACOXL CA1 CA3 CA2 CA4 CA7 CA6 CA9 GIF CYP4A11 CAD ACOX2 ACOX3 NAT8L CARKD GALT SLC3A2 PPOX NT5C2 GK2 CBS OXCT1 TGS1 OXCT2 CRYM HSD3B7 RRM1 RRM2 FAHD1 HSD3B2 HSD3B1 HS3ST5 HS3ST6 SUOX HS3ST4 HS3ST1 HS3ST2 GALC GALE SARDH GLA PI4K2B CDA PRSS1 XYLT2 XYLT1 NAMPT PRSS3 GAMT MTAP PRKD3 HMBS PRKD2 PRKD1 ADPRM PI4K2A LIPT2 LIPT1 TPH2 RPS4Y2 RPS4Y1 SDSL ADH7 GNS ADH5 ACMSD ADH6 LDHC ADH4 LDHB LDHA TTPA ST3GAL4 HMOX1 ST3GAL6 CGA ST3GAL1 HMOX2 ST3GAL2 LHPP ST3GAL3 FDFT1 NR1D1 SQLE TCN2 TCN1 ADI1 PAH PPT1 MMS19 PPT2 ITPA PYGB MOCS2 MOCS3 GPT PYGM SIN3A PYGL CSAD TK2 TK1 COQ10B COQ10A NCOR2 GCHFR NCOR1 MTF1 PLIN3 AHRR PLIN2 PLIN1 ANGPTL4 TKT GART SGMS2 PAPSS2 PAPSS1 RPS15A FAM213B ALOX5 CKB LDLR CKM RNLS TPK1 NR1H2 GLYCTK GSS MOCOS NR1H4 G0S2 NR1H3 GNMT FDX1L AGMAT GATM N6AMT1 VKORC1L1 TPMT RPL10L RPL10A TM7SF2 PPP1CC CYSLTR2 MPC1 MPC2 CSGALNACT1 IPMK DIO1 CSGALNACT2 DIO2 DIO3 KERA PGD CSNK1G2 IPPK SLC26A2 SLC26A1 INSIG2 INSIG1 HMMR MTM1 TPO OSBPL9 RAB4A OSBPL7 ERCC2 OSBPL6 OSBPL3 OSBPL2 PHKB SYNJ2 SYNJ1 AMD1 PIK3C2G PIK3C2A FTCD PIK3C2B IDH3B PRKG2 HMGCS2 LBR IDH3A ADSL UGT1A1 HMGCS1 GGPS1 CHPF2 FAAH2 APOA2 APOA1 RPL13A APOA4 APOA5 TST PPAP2B PPAP2A ALDH9A1 RPEL1 PPAP2C TPTE PDHB CYP3A4 CYP3A5 BPHL CYP3A7 TTR UGT1A5 UGT1A4 UGT1A3 BCO2 BCO1 UGT1A9 ALOXE3 ADSS UGT1A8 UGT1A7 UGT1A6 IDH3G CYP51A1 APOC3 BCKDK RAB14 VAPA VAPB PSAT1 CTH APOC2 PANK4 SLC35B3 ISCA2 SLC35B2 PANK2 ISCA1 PANK3 MTRR PANK1 GBA2 HS6ST1 HS6ST2 HS6ST3 RPS15 RPS14 RPS17 RPS16 PNP RPS19 RPL18A RPL36AL RPS18 FLAD1 PDK4 PDK3 RPS11 RPS10 RPS13 PDK2 PSMD8 RPS12 PSMD9 PDK1 PSMD6 PDHX CPT1A PSMD7 CPT1B PSMD4 TIAM2 PSMD5 POR PSMD2 CYP2U1 MTHFD2L PSMD3 AKT1 SUCLG2 SUCLG1 PSMD1 SLC22A3 RTEL1 SLC22A5 PRKCA SLC35D1 SLC22A2 FUT10 PSMA5 STXBP1 PSMA6 SLC22A1 PSMA3 LHB PSMA4 FUT11 PSMA1 SLC35D2 LIAS PSMA2 HELZ2 PSME3 UGCG PSME4 PYCR1 PSME1 PYCR2 PSME2 NARFL TYR UBA52 DERA RPS26 PSMD10 PSMB11 PM20D1 RPS25 PSMD12 RPS28 HAL PSMD11 RPS27 PSMD14 VNN1 VNN2 PSMD13 RPS29 CYP2S1 PSMA7 PSMB10 RPS20 RPS21 PSMA8 RPS24 RPS23 CD320 PSMB6 GBE1 SLC22A13 PSMB7 PARP6 CBR1 PSMB4 PARP4 BHMT2 PSMB5 PARP9 PSMB2 CYP7B1 UBB PARP8 PSMB3 UGDH DTYMK ADH1C UBC ADH1B PSMB1 ADH1A PSMF1 HAAO HDC RPS27A GDPD1 GDPD3 ZDHHC21 GDPD5 SHFM1 TYMS CYP7A1 PSMB8 PTS PSMB9 TYMP PSMC5 NT5C PSMC6 DUOX1 PSMC3 NT5E PSMC4 PDPR PSMC1 MTHFD1L PSMC2 SPTSSB NT5M SPTSSA CBR4 DUOX2 CBR3 NFYA PTGES2 NFYB NFYC PTGES3 GRHL1 PDP1 CYP2W1 PDP2 GSTA5 GSTA4 GSTA3 GSTA2 GSTA1 NDUFA13 NDUFA11 NDUFA12 NDUFA10 COMT CNDP2 PHYH HGD NOSIP PPAPDC2 ATP5J2 PNLIP IDI1 ISYNA1 IDI2 ALOX15 LPL ALOX12 MPST CYP2J2 IDH1 IDH2 COQ9 COQ7 COQ6 COQ5 GRHPR COQ3 SEPSECS COQ2 AMACR DAO PXMP2 CRYL1 PI4KB LRP10 LRP12 ADCY9 GLP1R PYCRL PRKAR1B ATP5G3 DBH PRKAR1A OPLAH NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION%REACTOME%R-HSA-164940.1 Nef mediated downregulation of MHC class I complex cell surface expression HLA-A B2M AP1M2 AP1M1 AP1G1 PACS1 AP1S2 AP1B1 AP1S1 AP1S3 LIGAND-DEPENDENT CASPASE ACTIVATION%REACTOME%R-HSA-140534.5 Ligand-dependent caspase activation CASP8 TRADD TNFSF10 FAS TNFRSF10B FASLG RIPK1 TNFRSF10A TRAF2 FADD TICAM2 LY96 TICAM1 CD14 TLR4 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES%REACTOME%R-HSA-1169410.3 Antiviral mechanism by IFN-stimulated genes NUP107 NUP188 KPNA1 UBA52 NUP62 NDC1 NUP214 SEC13 NUP133 NUP210 EIF4A2 EIF4A1 EIF4E3 UBE2E1 UBE2L6 NUP93 IFIT1 NUP50 OASL HERC5 UBB TRIM25 NUP54 KPNA7 KPNA4 ARIH1 UBC KPNA5 KPNA2 KPNA3 JAK1 RPS27A DDX58 PPM1B KPNB1 OAS1 IRF3 PDE12 OAS2 POM121 OAS3 NUP205 USP41 EIF4E2 EIF4A3 RNASEL AAAS MAPK3 UBA7 NUP160 USP18 FLNA NUP85 FLNB TPR EIF4E EIF4G1 STAT1 NUP88 MX2 NUP43 MX1 EIF2AK2 ISG15 RAE1 NEDD4 UBE2N RANBP2 ABCE1 EIF4G3 EIF4G2 NUP155 NUP153 PLCG1 NUP35 NUPL2 NUP37 PIN1 MTOR SIGNALLING%REACTOME%R-HSA-165159.5 mTOR signalling AKT1 TSC2 PRKAB1 TSC1 RRAGA EIF4E EIF4G1 RRAGC RRAGB RRAGD SLC38A9 CAB39 CAB39L EEF2K PRKAA1 EIF4EBP1 EIF4B PRKAA2 STRADA STRADB PPM1A RPS6 RPS6KB1 AKT1S1 MTOR RHEB LAMTOR2 LAMTOR1 LAMTOR4 LAMTOR3 LAMTOR5 YWHAB AKT2 PRKAG1 STK11 MLST8 PRKAG2 PRKAG3 RPTOR PRKAB2 TRANS-GOLGI NETWORK VESICLE BUDDING%REACTOME DATABASE ID RELEASE 72%199992 trans-Golgi Network Vesicle Budding VAMP2 OCRL HGS APP TFRC SNAP23 CTSZ AP4E1 ARRB1 CLINT1 AP4M1 AP1G2 FTH1 AP3S1 SH3GL2 SH3D19 PIK3C2A TPD52 AP3B1 GAK VAMP8 VAMP7 DNAJC6 DNASE2 FTL NAPA DNM2 RAB5C TGOLN2 BLOC1S4 BLOC1S6 SNX2 BLOC1S1 BLOC1S3 CLVS2 GNS STX4 HSPA8 SNX9 AP4S1 SNX5 TXNDC5 CLVS1 TBC1D8B SNAPIN SORT1 GBF1 DTNBP1 HIP1R M6PR PUM1 TPD52L1 AP4B1 IGF2R NECAP1 GOLGB1 CPD YIPF6 CHMP2A ACBD3 PICALM AP1G1 AP1S2 AP1B1 AP1S1 CLTC AP1S3 ARF1 CLTB CLTA AP1M2 AP1M1 LOSS OF FUNCTION OF TGFBR2 IN CANCER%REACTOME%R-HSA-3642278.1 Loss of Function of TGFBR2 in Cancer TGFB1 TGFBR1 TGFBR2 RNF MUTANTS SHOW ENHANCED WNT SIGNALING AND PROLIFERATION%REACTOME DATABASE ID RELEASE 72%5340588 RNF mutants show enhanced WNT signaling and proliferation RNF43 WNT3A FZD4 FZD6 LRP5 FZD8 LRP6 FZD5 ERK MAPK TARGETS%REACTOME DATABASE ID RELEASE 72%198753 ERK MAPK targets PPP2CA PPP2CB RPS6KA5 RPS6KA2 RPS6KA1 MAPK14 DUSP4 PPP2R5D MAPK11 MEF2A MEF2C DUSP3 VRK3 DUSP6 DUSP7 PPP2R1B PPP2R1A MAPK7 MAPK1 ELK1 MAPK3 RPS6KA3 TYPE II NA+ PI COTRANSPORTERS%REACTOME%R-HSA-427589.1 Type II Na+ Pi cotransporters SLC34A3 SLC34A2 SLC34A1 SHC1 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 72%180336 SHC1 events in EGFR signaling SHC1 HRAS EGFR SOS1 BTC EPGN TGFA NRAS AREG HBEGF EREG EGF FORMATION OF FIBRIN CLOT (CLOTTING CASCADE)%REACTOME%R-HSA-140877.2 Formation of Fibrin Clot (Clotting Cascade) SERPINE2 SERPINC1 PROS1 F13A1 PRCP TFPI KNG1 SERPINA5 THBD C1QBP A2M PF4V1 CD177 FGB FGA SERPIND1 VWF F10 GP1BB F12 F11 F2R FGG GP1BA F2 F3 GP5 F5 F7 PROCR GP9 F8 PROC F9 SERPING1 F13B PRTN3 KLKB1 PF4 RNA POLYMERASE I PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 72%73772 RNA Polymerase I Promoter Escape TAF1B TAF1C TAF1A TWISTNB POLR2E POLR2F POLR2H POLR2K CCNH POLR2L GTF2H1 GTF2H2 HIST1H2AE GTF2H3 HIST1H2AD GTF2H4 HIST3H2BB HIST1H2AC GTF2H5 HIST1H2AB HIST1H2AJ ERCC3 CD3EAP ERCC2 HIST2H3A HIST1H2BF HIST1H2BE HIST1H2BH HIST1H2BG HIST2H3D HIST1H2BB HIST1H2BA HIST2H3C HIST1H2BD HIST1H2BC H2AFB1 HIST1H3J HIST1H3A HIST1H3F HIST1H3G HIST1H3H HIST1H3I HIST1H3B HIST1H3C HIST1H3D HIST1H3E H3F3B HIST1H4K CBX3 RRN3 HIST1H4L H3F3A H2BFS HIST1H4A CDK7 HIST1H4B HIST1H4H HIST1H4I HIST1H4J HIST1H4C MNAT1 HIST1H4D HIST1H4E HIST1H4F HIST2H2AA3 HIST2H2AA4 HIST2H2AC ZNRD1 H2AFJ UBTF TBP H2AFZ H2AFX H2AFV HIST2H2BE POLR1A HIST4H4 POLR1B POLR1C POLR1E HIST1H2BN HIST1H2BM HIST1H2BO HIST1H2BJ HIST1H2BI HIST1H2BL HIST1H2BK HIST2H4A TAF1D HIST2H4B CARDIAC CONDUCTION%REACTOME DATABASE ID RELEASE 72%5576891 Cardiac conduction CAMK2D CAMK2A CACNG8 CACNG2 CAMK2G CACNG3 CACNG4 CACNA2D2 PRKACA SLC8A1 SLC8A2 NPPC SLN SCN11A NPPA SCN9A SCN1B SCN1A KCNH2 KCNK10 CACNA2D1 KCNK12 KCNK13 CACNA2D3 KCNK15 ATP1B3 KCNK16 ATP1B2 KCNK17 CACNA2D4 ATP1B1 KCNK18 CACNB1 SCN10A CACNB4 STIM1 KCNQ1 SCN8A ORAI2 ORAI1 KCNE1 KCNE2 KCNE3 KCNE4 NPR1 KCNE5 NPR2 GATA4 CACNA1F CACNA1S SCN3B NKX2-5 SCN3A WWTR1 DMPK FGF14 FXYD4 FXYD3 FXYD2 CACNA1D FXYD1 FXYD7 CACNA1C FXYD6 SCN2A CACNB2 FGF13 CACNB3 FGF12 FGF11 SCN2B KCNK5 RYR1 KCNK6 RYR2 AHCYL1 KCNK7 KCNK9 ATP2A3 ATP2A2 ATP2A1 RYR3 AKAP9 SCN5A NOS1 CLIC2 KCND1 KCND2 KCND3 TRPC1 ABCC9 TRDN ASPH SCN4A SCN4B ATP1A4 ATP1A3 ATP1A2 ATP1A1 SRI CACNG6 CACNG7 PLN SCN7A TNNI3 KCNJ2 CORIN KCNJ4 KCNIP1 KCNJ12 KCNIP2 KCNIP3 KCNJ14 KCNIP4 ATP2B4 ITPR1 ATP2B3 ITPR2 ATP2B2 ITPR3 ATP2B1 TBX5 SLC8A3 FKBP1B RANGRF KCNK1 KCNK2 KCNK3 KCNK4 KCNJ11 HIPK1 HIPK2 KAT2B CAMK2B APC TRUNCATION MUTANTS ARE NOT K63 POLYUBIQUITINATED%REACTOME%R-HSA-5467333.1 APC truncation mutants are not K63 polyubiquitinated APC MET RECEPTOR RECYCLING%REACTOME DATABASE ID RELEASE 72%8875656 MET receptor recycling GAB1 GGA3 RAB4B HGF MET CRKL CRK ARF6 RAB4A ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC%REACTOME DATABASE ID RELEASE 72%983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC HLA-G SEC24B HLA-E SEC23A TAPBP SEC24A SEC31A PDIA3 CANX HLA-A CALR SEC24D B2M SEC24C HSPA5 ERAP2 ERAP1 HLA-B TAP2 HLA-C TAP1 SEC13 SAR1B HLA-F SYNTHESIS OF IPS IN THE NUCLEUS%REACTOME DATABASE ID RELEASE 72%1855191 Synthesis of IPs in the nucleus IP6K2 IPPK IPMK IP6K1 POSTMITOTIC NUCLEAR PORE COMPLEX (NPC) REFORMATION%REACTOME DATABASE ID RELEASE 72%9615933 Postmitotic nuclear pore complex (NPC) reformation NUP133 NUP85 TNPO1 NUP43 AHCTF1 RANGAP1 NUP93 RCC1 UBE2I NUP54 NUP107 NUP155 NUP188 RAN KPNB1 POM121 NUP62 NUP205 NUP35 NDC1 SUMO1 SEC13 NUP160 NUP37 DEFECTIVE ABCA1 CAUSES TANGIER DISEASE%REACTOME DATABASE ID RELEASE 72%5682113 Defective ABCA1 causes Tangier disease ABCA1 APOA1 DNA REPAIR%REACTOME DATABASE ID RELEASE 72%73894 DNA Repair EXO1 TOPBP1 RFC5 RFC3 RFC4 RAD23B RFC2 CCNA2 CCNA1 RBBP8 RAD50 POLR2A POLR2B POLR2C POLR2D POLR2G POLR2I POLR2J CETN2 UBE2I ALKBH3 ALKBH2 ALKBH5 HERC2 PPP4R2 STRA13 NFRKB RNF111 FAAP100 AQR TIPIN TINF2 REV1 NEIL3 NEIL2 NEIL1 ZNF830 PAXIP1 CCNH PRKDC XPA COPS7B XPC COPS7A ACTB BRCC3 PPP4C NTHL1 HIST1H2AE TP53BP1 HIST1H2AD HIST3H2BB NHEJ1 ACD HIST1H2AC XRCC6 HIST1H2AB XRCC4 XRCC5 HIST1H2AJ XRCC2 XRCC3 XRCC1 INO80 HIST1H2BF PPP5C HIST1H2BE NPLOC4 HIST1H2BH TDP2 HIST1H2BG TDP1 SPRTN HIST1H2BB BAP1 HIST1H2BA RAD18 WDR48 HIST1H2BD OGG1 HIST1H2BC BRCA2 H2AFB1 PRPF19 BABAM1 UIMC1 REV3L PARP1 PARP2 ACTL6A SIRT6 TERF1 TERF2 RAD51B RNF168 DDB1 RAD51C HIST1H4K POT1 GPS1 HIST1H4L FAAP24 FAAP20 SMARCA5 SLX4 USP1 H2BFS HIST1H4A APBB1 MBD4 CDK7 HIST1H4B MGMT HIST1H4H MCRS1 HIST1H4I MAD2L2 HIST1H4J XAB2 HIST1H4C APITD1 APEX1 MNAT1 HIST1H4D DCLRE1B HIST1H4E DCLRE1A DCLRE1C RIF1 HIST1H4F MPG HIST2H2AA3 YY1 EME1 HIST2H2AA4 EME2 RUVBL1 HMGN1 GEN1 HIST2H2AC PIAS3 ADPRHL2 SLX1B LIG4 LIG3 H2AFJ CHD1L PIAS1 MSH6 MSH3 TIMELESS UBE2V2 PPIE H2AFZ SLX1A INO80C H2AFX FTO INO80B INO80E H2AFV BAZ1B INO80D RAD51AP1 HIST2H2BE ABL1 CLSPN UBE2B FANCM FANCL FANCA HIST4H4 FANCB FANCE PALB2 FANCG FANCF COPS4 HIST1H2BN COPS3 HIST1H2BM COPS6 COPS5 HIST1H2BO UBE2T HIST1H2BJ COPS2 UVSSA FAM175A HIST1H2BI COPS8 HIST1H2BL UFD1L HIST1H2BK ISY1 HIST2H4A MUS81 FEN1 POLB HIST2H4B BLM POLI PCNA POLL LIG1 WHSC1 RPA1 POLK RPA2 POLE POLH POLD3 TDG RFC1 POLD4 WRN USP43 RPA3 ACTR5 USP45 POLD1 POLR2E RAD23A POLD2 POLR2F DNA2 ACTR8 SPIDR POLR2H TERF2IP DTL FAN1 PARG USP10 POLR2K PNKP POLR2L RNF8 RNF4 RCHY1 GTF2H1 TFPT MAPK8 GTF2H2 ASCC2 GTF2H3 ASCC3 GTF2H4 POLQ KDM4A GTF2H5 KDM4B POLN EYA1 ASCC1 ERCC3 POLM ERCC2 EYA2 ERCC6 EYA3 EYA4 SMUG1 RAD52 CUL4A POLE4 RAD51 KIAA0101 BRE ERCC4 ERCC1 POLE2 HIST3H3 POLE3 ERCC8 MDC1 ERCC5 CUL4B KAT5 CHEK2 CHEK1 HUS1 TP53 RHNO1 BRIP1 ATRIP BARD1 RAD17 ATM ATR ELL BRCA1 SUMO1 SUMO3 SUMO2 RTEL1 RMI2 RMI1 TOP3A DDB2 RAD51D PIAS4 UBA52 PMS2 MRE11A MLH1 EP300 UBE2L6 TCEA1 RAD1 UBB TRIM25 UBC KPNA2 RPS27A NBN USP7 UBA7 MSH2 FANCD2 ISG15 UBE2N FANCI FANCC CDK2 RAD9B RAD9A VCP RBX1 SUMO IS TRANSFERRED FROM E1 TO E2 (UBE2I, UBC9)%REACTOME%R-HSA-3065678.2 SUMO is transferred from E1 to E2 (UBE2I, UBC9) SUMO2 UBA2 RWDD3 SAE1 UBE2I SUMO1 SUMO3 RECOGNITION OF DNA DAMAGE BY PCNA-CONTAINING REPLICATION COMPLEX%REACTOME%R-HSA-110314.1 Recognition of DNA damage by PCNA-containing replication complex RPA1 POLE RPA2 POLD3 POLD4 RFC1 RPA3 POLD1 POLD2 RFC5 RFC3 RFC4 DTL RFC2 UBA52 CUL4A POLE4 UBE2B RAD18 WDR48 POLE2 UBB POLE3 UBC CUL4B RPS27A DDB1 RBX1 PCNA USP1 EUKARYOTIC TRANSLATION ELONGATION%REACTOME%R-HSA-156842.2 Eukaryotic Translation Elongation RPL26 RPL29 RPL10L RPS4X RPL10A RPL28 RPS3A RPL7A RPL23A FAU RPL41 RPS27L RPL3L UBA52 RPL37A RPS26 RPS25 RPS28 RPS27 RPL36A RPS29 RPL35A RPS20 RPS21 RPS24 RPS23 RPL22L1 RPS4Y2 RPL10 RPS4Y1 RPS27A RPL12 RPL13A RPL11 RPS3 EEF1B2 RPL14 EEF1A1 RPL13 EEF1G EEF1D RPS2 EEF1A2 RPL15 RPL18 EEF2 RPL17 RPL19 RPL27A RPL26L1 RPL4 RPL39L RPL5 RPL30 RPL3 RPL32 RPL31 RPS9 RPS7 RPL34 RPS8 RPL8 RPS5 RPL9 RPS6 RPL6 RPL7 RPSA RPL36 RPS15 RPS14 RPL35 RPS17 RPL38 RPS16 RPL37 RPL39 RPS19 RPS15A RPL18A RPL36AL RPS18 RPLP1 RPL21 RPL23 RPS11 RPL22 RPLP0 RPS10 RPS13 RPS12 RPLP2 RPL24 RPL27 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL%REACTOME DATABASE ID RELEASE 72%198323 AKT phosphorylates targets in the cytosol TSC2 AKT1 AKT1S1 GSK3A CHUK BAD CASP9 MKRN1 MDM2 GSK3B CDKN1A CDKN1B AKT2 AKT3 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE%REACTOME DATABASE ID RELEASE 72%392154 Nitric oxide stimulates guanylate cyclase PDE1A PDE2A PDE11A NOS3 PDE10A KCNMB1 KCNMA1 KCNMB2 KCNMB3 KCNMB4 MRVI1 PRKG2 PDE5A PDE9A ITPR1 NOS1 GUCY1A3 GUCY1B3 GUCY1A2 NOS2 PDE1B PLATELET HOMEOSTASIS%REACTOME%R-HSA-418346.2 Platelet homeostasis TRPC7 PTGIR TRPC6 SRI TRPC3 PPP2R5B PPP2R5A FGR PTPN11 PAFAH2 P2RX7 P2RX6 GNAS APOB P2RX5 P2RX4 P2RX3 P2RX2 PPP2R5C P2RX1 PTPN6 ATP2B4 ITPR1 ATP2B3 ITPR2 ATP2B2 ITPR3 ATP2B1 SLC8A3 PPP2R1B PPP2R1A NOS3 PPP2R5D PRKG2 SLC8A1 SLC8A2 GNG10 GNG12 PPP2CA GNG11 PPP2CB GNG13 MAPK14 GNB2 GNB1 GNB4 STIM1 GNB3 ORAI2 ORAI1 GNB5 GNGT1 GNGT2 GUCY1A3 GUCY1B3 GUCY1A2 NOS2 PDE1B PDE1A PDE2A PLA2G4A PDE11A PDE10A KCNMB1 KCNMA1 KCNMB2 KCNMB3 KCNMB4 MRVI1 PDE5A GNG3 PDE9A GNG2 GNG5 GNG4 ATP2A3 GNG7 ATP2A2 GNG8 ATP2A1 LRP8 NOS1 PPP2R5E SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER%REACTOME%R-HSA-3304356.2 SMAD2 3 Phosphorylation Motif Mutants in Cancer SMAD2 TGFB1 SMAD3 TGFBR1 TGFBR2 ACTIVATED NTRK2 SIGNALS THROUGH CDK5%REACTOME DATABASE ID RELEASE 72%9032845 Activated NTRK2 signals through CDK5 TIAM1 NTRK2 CDK5 BDNF RAC1 CDK5R1 ASYMMETRIC LOCALIZATION OF PCP PROTEINS%REACTOME DATABASE ID RELEASE 72%4608870 Asymmetric localization of PCP proteins PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 UBA52 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 SCRIB PSMA8 PRICKLE1 DVL2 PSMB6 FZD1 FZD3 PSMB7 SMURF2 FZD7 PSMB4 VANGL2 PSMB5 PSMB2 UBB PSMB3 UBC PSMB1 PSMF1 RPS27A SHFM1 PSMB8 PSMB9 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 FZD4 FZD8 SMURF1 FZD2 FZD5 WNT5A PARD6A PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 TOXICITY OF BOTULINUM TOXIN TYPE E (BONT E)%REACTOME DATABASE ID RELEASE 72%5250992 Toxicity of botulinum toxin type E (BoNT E) SV2B SV2A SNAP25 INSULIN EFFECTS INCREASED SYNTHESIS OF XYLULOSE-5-PHOSPHATE%REACTOME DATABASE ID RELEASE 72%163754 Insulin effects increased synthesis of Xylulose-5-Phosphate TKT TALDO1 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME%R-HSA-69580.3 p53-Dependent G1 S DNA damage checkpoint PSMD3 PSMD1 ZNF385A PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 CCNA2 CCNA1 UBA52 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 CDKN2A PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 UBB PSMB3 RFWD2 UBC PSMB1 PSMF1 RPS27A CHEK2 SHFM1 PSMB8 PSMB9 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 CCNE2 CCNE1 TP53 PCBP4 ATM CDK2 MDM2 CDKN1A MDM4 CDKN1B PHF20 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PACKAGING OF EIGHT RNA SEGMENTS%REACTOME%R-HSA-168303.3 Packaging of Eight RNA Segments VARIANT SLC6A20 CONTRIBUTES TOWARDS HYPERGLYCINURIA (HG) AND IMINOGLYCINURIA (IG)%REACTOME%R-HSA-5619101.1 Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG) SLC6A20 ATP SENSITIVE POTASSIUM CHANNELS%REACTOME%R-HSA-1296025.1 ATP sensitive Potassium channels KCNJ8 ABCC8 ABCC9 KCNJ11 LIPOPROTEIN METABOLISM%REACTOME%R-HSA-174824.4 Lipoprotein metabolism ALB APOE AMN APOB PRKACG PRKACA PRKACB SAR1B A2M APOA2 APOA1 APOA4 APOA5 MBTPS1 HDLBP PCSK9 APOC3 VLDLR ZDHHC8 MBTPS2 LIPA LIPC CREB3L3 LIPG LDLRAP1 APOC2 MYLIP LSR SOAT1 NPC1 SOAT2 NPC2 ANGPTL3 LPA GPIHBP1 ABCG1 ABCA1 CETP C19orf80 MTTP LPL ANGPTL4 LCAT LMF2 LMF1 APOF FGF21 APOC4 APOBR CUBN NCEH1 CLTC APOC1 P4HB CLTA LDLR AP2A1 AP2B1 AP2A2 AP2S1 NR1H2 AP2M1 NR1H3 FURIN PCSK6 CES3 PCSK5 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX%REACTOME%R-HSA-937042.2 IRAK2 mediated activation of TAK1 complex UBC RPS27A UBA52 IRAK2 TRAF6 TAB3 TAB2 TAB1 UBB MAP3K7 SEROTONIN RECEPTORS%REACTOME DATABASE ID RELEASE 72%390666 Serotonin receptors HTR1B HTR2C HTR2A HTR4 HTR5A HTR6 HTR7 HTR1E HTR1F HTR1D HTR2B HTR1A METHYLATION OF MESEH FOR EXCRETION%REACTOME DATABASE ID RELEASE 72%2408552 Methylation of MeSeH for excretion INMT TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES%REACTOME%R-HSA-425397.3 Transport of vitamins, nucleosides, and related molecules SLCO4C1 ALB SLCO2A1 SLC27A1 LCN1 SLC27A6 SLC29A4 AVP SLC35D1 SLC28A2 SLCO1A2 SLC29A1 SLC28A1 SLC29A3 SLC28A3 SLC29A2 SLC27A4 SLC35D2 SLC35B3 SLC35B2 SLC25A5 SLC25A4 SLC25A6 LCN9 SLC35B4 LCN15 PDZD11 LCN12 SLCO2B1 APOD SLC16A2 SLC5A6 SLC35A2 ARL2 SLC35A1 SLC35A3 SLCO1B1 SLC35C1 SLCO1B3 SLC33A1 SLCO1C1 ARL2BP SLCO4A1 CHROMATIN MODIFYING ENZYMES%REACTOME%R-HSA-3247509.4 Chromatin modifying enzymes TAF9 TAF12 TAF10 GPS2 CARM1 RPS2 EHMT2 ARID4B ACTB SAP130 HIST1H2AE HIST1H2AD SMARCD3 HIST3H2BB HIST1H2AC HIST1H2AB HIST1H2AJ SAP30 HIST2H3A HIST1H2BF HIST1H2BE HIST1H2BH HIST1H2BG HIST2H3D HIST1H2BB HIST1H2BA HIST2H3C HIST1H2BD HIST1H2BC H2AFB1 HIST1H3J HIST1H3A HIST1H3F HIST1H3G HIST1H3H ACTL6A HIST1H3I SUDS3 HIST1H3B HIST1H3C HIST1H3D HIST1H3E HIST1H4K HIST1H4L HIST1H4A HIST1H4B HIST1H4H MCRS1 HIST1H4I HIST1H4J HIST1H4C HIST1H4D HIST1H4E EZH2 HIST1H4F HIST2H2AA3 HIST2H2AA4 RUVBL1 SUV39H1 CHD3 HIST2H2AC H2AFJ EED H2AFZ NCOR2 DNMT3A H2AFX NCOR1 HDAC3 H2AFV SUV420H2 SMARCB1 HDAC10 HIST2H2BE TRRAP KAT2B SUV420H1 KAT2A KAT8 AEBP2 EPC1 KAT7 HIST4H4 SUPT20H ATXN7L3 CSRP2BP SMARCC1 SMARCC2 HCFC1 HIST1H2BN JMJD6 HIST1H2BM WDR77 HDAC2 PADI3 HIST1H2BO PADI2 HIST1H2BJ PADI4 HDAC1 PADI1 PADI6 HIST1H2BI PRDM16 HIST1H2BL SETDB1 HIST1H2BK SETD1B SETD1A HIST2H4A SETDB2 MINA HIST2H4B SMARCA2 MTA1 SMARCA4 WHSC1 RBBP4 TADA2B ZZZ3 TADA2A PHF2 TBL1X SAP30L SUV39H2 SETD2 SETD3 SETD6 SETD7 SAP18 HIST2H2AB ASH2L RBBP7 IKBKAP MTA2 PHF8 ING4 MTA3 ING3 MECOM JAK2 MBD3 PRMT6 SUZ12 PBRM1 PRMT7 ACTL6B PRMT3 PAX3 TBL1XR1 ASH1L HIST2H2BF GATAD2B KDM4A SUPT3H KDM4B TAF6L GATAD2A CCDC101 CLOCK DOT1L RELA NSD1 BRD8 ELP2 ELP3 ELP4 ELP5 ELP6 HIST3H2A PRDM9 KDM1A KDM1B JADE1 ARID4A JADE3 YEATS4 JADE2 CCND1 RUVBL2 HIST1H2AG ARID2 EHMT1 HIST1H2AA WHSC1L1 HIST1H2AM HIST1H2AL KAT5 KDM2A HIST1H2AI KDM2B HIST1H2AH HIST1H2AK ARID5B SUPT7L MORF4L1 BRMS1 KAT6B MORF4L2 HAT1 KMT2E KMT2D ENY2 KMT2A KMT2C KMT2B TAF5L PHF21A ATXN7 MBIP EP400 DMAP1 MEAF6 SMYD3 DR1 NFKB1 NFKB2 COPRS MRGBP YEATS2 CDK4 TADA3 TADA1 BRWD1 OGT NCOA1 KDM5A KDM5B KDM5C NCOA2 KDM5D CREBBP DPY30 VPS72 WDR5 HMG20B UTY KDM6A KDM6B MSL2 MSL3 ARID1A ARID1B MSL1 KDM7A SMARCD1 KDM3A SMARCD2 KDM3B HDAC8 RBBP5 SMARCE1 ATF7IP SETD8 KDM4C KDM4D PHF20 USP22 KANSL1 KANSL2 KANSL3 ING5 PRMT5 BRD1 PRMT1 ATF2 CHD4 EP300 REST KAT6A AK6 SMYD2 BRPF1 BRPF3 RESISTANCE OF ERBB2 KD MUTANTS TO LAPATINIB%REACTOME DATABASE ID RELEASE 72%9665251 Resistance of ERBB2 KD mutants to lapatinib ERBB2IP HSP90AA1 CDC37 ERBB2 PHOSPHORYLATION SITE MUTANTS OF CTNNB1 ARE NOT TARGETED TO THE PROTEASOME BY THE DESTRUCTION COMPLEX%REACTOME%R-HSA-4839743.1 phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex CSNK1A1 PPP2CA PPP2CB PPP2R5B PPP2R5A PPP2R5D CTNNB1 GSK3B PPP2R5C PPP2R1B PPP2R1A AMER1 AXIN1 APC PPP2R5E LEISHMANIA PARASITE GROWTH AND SURVIVAL%REACTOME DATABASE ID RELEASE 72%9664433 Leishmania parasite growth and survival PRKAR2B PRKAR2A CYSLTR2 HTR6 PLCG2 HTR7 GNAS HTR4 ADCY4 VIPR1 ADCY3 VIPR2 PRKACG SCT ADCY2 RXFP1 PRKACA ADCY1 RXFP2 PRKACB ADCY8 IGHG4 ADCY7 CYSLTR1 ADCY6 GPR176 ADCY5 IGHG1 IGHG2 IGKV1-12 PTGDR LHCGR TAAR8 TAAR9 TAAR6 TAAR5 TAAR2 TAAR1 ADCYAP1 ADAM17 IGKV2D-28 IGKV4-1 IAPP ADCYAP1R1 CALCA CALCRL CALCB IGKV2D-30 GIPR GPR83 ADRB1 GPR84 ADRB2 CRHR1 CRHR2 GHRHR TSHB GCG MC2R CALCR HRH2 DRD1 IGKV3-11 DRD5 LYN CD163 GPR15 AVP YES1 IL6 MC1R RLN2 RLN3 GPR27 GPR25 GPR20 ADM CD3G PTH1R MC4R FCGR3A IGKV2-28 INSL3 IL10 GPR39 SYK FSHB GPR32 AVPR2 GLP2R POMC RHBDF2 IGKV3D-20 GPBAR1 PTH2R GIP MC3R PLK2 HCK ADORA2A ADRB3 ADORA2B FSHR CRH MYH9 NPSR1 PTGER4 RAMP2 AHCYL1 RAMP3 GPR45 PTH PTGER2 PRKX PTH2 PTHLH NPS GPR150 FCGR1A GPHA2 P2RY11 IGKV5-2 SCTR TSHR FCGR2A FURIN GHRH ADM2 MC5R VIP RAMP1 PTGIR GPHB5 GGT1 FGR DPEP2 DPEP1 LHB DPEP3 ITPR1 ITPR2 ITPR3 FYN GGT5 GNAT3 CREB1 GNAZ GNG10 GNG12 GNG11 GNG13 CGA GNB2 MAPK14 GNB1 GNB4 GNB3 GNB5 GNGT1 GNGT2 PLCG1 GNAI3 GNAI1 GNAI2 GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 ADCY9 GLP1R PRKAR1B PRKAR1A RNA POLYMERASE I TRANSCRIPTION INITIATION%REACTOME%R-HSA-73762.3 RNA Polymerase I Transcription Initiation RBBP4 TAF1B CDK7 TAF1C TAF1A TWISTNB POLR2E MNAT1 POLR2F POLR2H RBBP7 MTA2 MTA3 POLR2K CCNH POLR2L EHMT2 MBD3 CHD3 TTF1 GTF2H1 ZNRD1 GTF2H2 GTF2H3 GTF2H4 UBTF GATAD2B GTF2H5 GATAD2A TBP CHD4 ERCC3 CD3EAP ERCC2 ERCC6 KAT2B KAT2A POLR1A POLR1B POLR1C POLR1E HDAC2 HDAC1 RRN3 TAF1D MTA1 EUKARYOTIC TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 72%72613 Eukaryotic Translation Initiation RPL26 RPL29 RPL10L RPS4X RPL10A RPL28 RPS3A RPL23A FAU RPL41 RPL3L RPL10 RPL12 RPL13A RPL11 RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL27A RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS15 RPS14 RPS17 RPS16 RPS19 RPL18A RPL36AL RPS18 RPLP1 RPS11 RPS10 RPLP0 RPS13 RPS12 RPLP2 RPL7A RPS27L PABPC1 UBA52 RPL37A RPS26 RPS25 RPS28 EIF1AX RPS27 EIF2B5 RPL36A EIF2B4 EIF2B3 RPS29 EIF2B2 EIF2S2 RPS20 RPL35A EIF2S1 RPS21 EIF5 RPS24 EIF2S3 RPS23 EIF2B1 EIF5B EIF4A2 EIF4H EIF4A1 EIF3M EIF3K EIF3L RPL22L1 EIF3I EIF3J EIF3G EIF3H EIF3E EIF3F EIF3C EIF3D EIF3A RPS4Y2 EIF3B RPS4Y1 RPS27A EIF4G1 EIF4E RPL26L1 RPL4 RPL39L RPL5 RPL30 RPL3 RPL32 EIF4EBP1 RPL31 EIF4B RPL34 RPL8 RPL9 RPL6 RPL7 RPL36 RPL35 RPL38 RPL37 RPL39 RPS15A RPL21 RPL23 RPL22 RPL24 RPL27 HYDROLYSIS OF LPE%REACTOME DATABASE ID RELEASE 72%1483152 Hydrolysis of LPE PLA2G4C GPCPD1 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 72%416993 Trafficking of GluR2-containing AMPA receptors NSF GRIA2 AP2A1 PICK1 GRIP1 PRKCA TSPAN7 GRIA3 GRIA1 GRIA4 PRKCG PRKCB DEFECTIVE GCK CAUSES MATURITY-ONSET DIABETES OF THE YOUNG 2 (MODY2)%REACTOME DATABASE ID RELEASE 72%5619073 Defective GCK causes maturity-onset diabetes of the young 2 (MODY2) GCK XBP1(S) ACTIVATES CHAPERONE GENES%REACTOME DATABASE ID RELEASE 72%381038 XBP1(S) activates chaperone genes SEC31A PPP2R5B GSK3A EDEM1 SYVN1 SHC1 CUL7 DCTN1 FKBP14 GOSR2 SRPR CXXC1 ADD1 PLA2G4B MYDGF EXTL2 EXTL1 ACADVL SERP1 TATDN2 LMNA DNAJB9 SSR1 EXTL3 TSPYL2 ZBTB17 SULT1A3 KLHDC3 WFS1 DDX11 GFPT1 WIPI1 PDIA6 YIF1A ARFGAP1 PDIA5 DNAJC3 CTDSP2 DNAJB11 SRPRB TPP1 PREB HDGF HYOU1 KDELR3 TLN1 ATP6V0D1 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S%REACTOME DATABASE ID RELEASE 72%72662 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S RPS4X RPS3A FAU RPS27L PABPC1 RPS26 RPS25 RPS28 EIF1AX RPS27 RPS29 EIF2S2 RPS20 EIF2S1 RPS21 RPS24 EIF2S3 RPS23 EIF4A2 EIF4H EIF4A1 EIF3M EIF3K EIF3L EIF3I EIF3J EIF3G EIF3H EIF3E EIF3F EIF3C EIF3D EIF3A RPS4Y2 EIF3B RPS4Y1 RPS27A RPS3 RPS2 EIF4E EIF4G1 EIF4EBP1 RPS9 EIF4B RPS7 RPS8 RPS5 RPS6 RPSA RPS15 RPS14 RPS17 RPS16 RPS19 RPS15A RPS18 RPS11 RPS10 RPS13 RPS12 NEGATIVE FEEDBACK REGULATION OF MAPK PATHWAY%REACTOME DATABASE ID RELEASE 72%5674499 Negative feedback regulation of MAPK pathway MAP2K1 MAP2K2 BRAF RAF1 MAPK1 MAPK3 IRON UPTAKE AND TRANSPORT%REACTOME%R-HSA-917937.3 Iron uptake and transport CUL1 UBA52 ABCG2 TFRC FTH1 SLC46A1 UBB FTL UBC STEAP3 HFE SLC40A1 TCIRG1 HEPH RPS27A SLC22A17 ATP6V1E1 ATP6V1E2 ATP6V1G1 ATP6V0B ATP6V0E1 ATP6V1G2 ATP6AP1 GLRX3 SLC11A2 TFR2 ATP6V1B2 STEAP2 HMOX1 ATP6V0C ATP6V0D2 ATP6V1B1 ATP6V1A HMOX2 IREB2 NEDD8 CAND1 FTMT ATP6V0A2 ATP6V1H ATP6V0A4 ATP6V0E2 FBXL5 ATP6V1G3 ATP6V1D ATP6V1C1 ATP6V1F ATP6V0A1 ATP6V1C2 CYBRD1 MCOLN1 CP TF LCN2 ACO1 SKP1 ATP6V0D1 NADPH REGENERATION%REACTOME%R-HSA-389542.2 NADPH regeneration IDH1 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA%REACTOME%R-HSA-3359475.1 Defective MMAA causes methylmalonic aciduria type cblA MMAA MUT COLLAGEN CHAIN TRIMERIZATION%REACTOME%R-HSA-8948216.2 Collagen chain trimerization COL17A1 COL18A1 COL15A1 COL16A1 COL13A1 COL14A1 COL11A1 COL11A2 COL12A1 COL19A1 COL10A1 COL28A1 COL26A1 COL27A1 COL24A1 COL25A1 COL22A1 COL23A1 COL1A1 COL3A1 COL2A1 COL1A2 COL4A2 COL5A1 COL4A1 COL6A2 COL7A1 COL4A4 COL5A3 COL5A2 COL6A1 COL4A3 COL8A2 COL4A6 COL9A1 COL20A1 COL21A1 COL6A3 COL4A5 COL8A1 COL9A3 COL6A6 COL9A2 COL6A5 PASSIVE TRANSPORT BY AQUAPORINS%REACTOME%R-HSA-432047.1 Passive transport by Aquaporins AQP8 AQP10 AQP9 AQP6 AQP7 AQP4 AQP5 AQP2 AQP3 AQP1 MIP AQP11 AQP12A SEPARATION OF SISTER CHROMATIDS%REACTOME DATABASE ID RELEASE 72%2467813 Separation of Sister Chromatids PPP1CC NUP107 PPP2R5C ERCC6L ZWILCH BUB1B CASC5 SMC3 CDC20 PTTG1 PPP2R1B PPP2R1A KNTC1 DYNC1LI1 BIRC5 DYNC1LI2 CLIP1 ZW10 MAD1L1 CDCA5 CDCA8 SEC13 PDS5B PDS5A PMF1 NUP133 SKA1 AURKB SKA2 DSN1 RAD21 PPP2R5D RCC2 NDC80 ZWINT STAG1 KIF18A STAG2 SGOL2 SGOL1 NUF2 WAPAL SPDL1 NDEL1 NUDC SMC1A DYNLL2 ESPL1 KIF2A INCENP KIF2C KIF2B ITGB3BP MIS12 CENPA NSL1 NUP160 CENPC PPP2CA BUB3 PPP2CB BUB1 NUP85 DYNC1I1 CLASP2 CENPT CENPU NUP43 CENPE CENPF CENPH CENPI TAOK1 RANBP2 CENPK CENPL CENPM CENPN B9D2 CENPO CENPP CENPQ SPC24 MAD2L1 SPC25 NUP37 DYNLL1 CKAP5 MAPRE1 PSMD8 PSMD9 PAFAH1B1 PSMD6 XPO1 DYNC1I2 PSMD7 PSMD4 PSMD5 PSMD2 PPP2R5E PSMD3 PSMD1 PPP2R5B PPP2R5A CLASP1 PSMA5 PSMA6 DYNC1H1 PSMA3 PSMA4 PSMA1 NDE1 PSMA2 PSME3 PSME4 PSME1 PSME2 UBA52 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 RPS27 PSMD13 PSMA7 PSMB10 PSMA8 ANAPC15 ANAPC16 PSMB6 ANAPC7 UBE2C PSMB7 PLK1 UBE2E1 PSMB4 UBE2D1 ANAPC10 PSMB5 ANAPC11 PSMB2 UBB CDC23 PSMB3 CDC26 CDC27 UBC CDC16 PSMB1 ANAPC4 PSMF1 ANAPC5 ANAPC1 RPS27A ANAPC2 SHFM1 PSMB8 PSMB9 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 APITD1 AHCTF1 RANGAP1 DEFECTIVE ABCB4 CAUSES PROGRESSIVE FAMILIAL INTRAHEPATIC CHOLESTASIS 3, INTRAHEPATIC CHOLESTASIS OF PREGNANCY 3 AND GALLBLADDER DISEASE 1%REACTOME%R-HSA-5678771.1 Defective ABCB4 causes progressive familial intrahepatic cholestasis 3, intrahepatic cholestasis of pregnancy 3 and gallbladder disease 1 ABCB4 MITOCHONDRIAL BIOGENESIS%REACTOME DATABASE ID RELEASE 72%1592230 Mitochondrial biogenesis ATP5G2 SIRT4 ATP5G1 SIRT5 TFB2M PPRC1 POLRMT TBL1X SIRT3 POLG2 ATP5F1 TFAM PERM1 ATP5C1 APOO SAMM50 MINOS1 HSPA9 APOOL TGS1 MTX1 HELZ2 MTX2 C10orf2 DNAJC11 IMMT SOD2 GLUD1 TMEM11 CAMK4 SSBP1 TBL1XR1 GLUD2 SMARCD3 ACSS2 ATF2 PRKAA2 NRF1 ATP5S MT-ATP6 MEF2C ATP5J MAPK12 ATP5I ATP5H ATP5O CHD9 ATP5L ATP5B ATP5E CREB1 ATP5D CARM1 MEF2D MT-ATP8 ALAS1 PRKAB2 PRKAB1 MAPK14 MAPK11 NR1D1 NCOA1 NCOA2 PPARGC1A CREBBP NCOA6 ATP5J2 NCOR1 HDAC3 PPARGC1B RXRA PPARA IDH2 MED1 CYCS HCFC1 ATP5A1 CRTC2 PRKAG1 CRTC3 CRTC1 PRKAG2 ESRRA TFB1M CHCHD3 PRKAG3 CHCHD6 ATP5G3 MTERF1 GABPA C19orf70 BIOSYNTHESIS OF PROTECTINS%REACTOME DATABASE ID RELEASE 72%9018681 Biosynthesis of protectins ALOX15 CYP1A2 LTA4H CYP1A1 LOSS OF PHOSPHORYLATION OF MECP2 AT T308%REACTOME DATABASE ID RELEASE 72%9022535 Loss of phosphorylation of MECP2 at T308 CAMK4 PRKACA SUMOYLATION OF IMMUNE RESPONSE PROTEINS%REACTOME%R-HSA-4755510.3 SUMOylation of immune response proteins NFKB2 PIAS3 NFKBIA UBE2I IKBKG IKBKE SUMO1 RELA TOPORS PIAS4 SUMO3 SUMOYLATION OF UBIQUITINYLATION PROTEINS%REACTOME DATABASE ID RELEASE 72%3232142 SUMOylation of ubiquitinylation proteins NUP85 TPR NUP88 NUP43 RAE1 RANBP2 NUP107 NUP155 NUP188 PIAS4 NUP153 PIAS1 NUP62 NUP35 NUPL2 NDC1 NUP214 SEC13 NUP37 TRIM27 VHL NUP133 NUP210 NUP93 NUP50 UBE2I MDM2 NUP54 PML POM121 NUP205 AAAS SUMO1 NUP160 SIGNALING BY LEPTIN%REACTOME DATABASE ID RELEASE 72%2586552 Signaling by Leptin JAK2 STAT3 PTPN11 STAT5A STAT5B SOCS3 IRS1 LEP IRS2 METABOLISM OF NITRIC OXIDE: ENOS ACTIVATION AND REGULATION%REACTOME DATABASE ID RELEASE 72%202131 Metabolism of nitric oxide: eNOS activation and regulation AKT1 NOS3 CAV1 SPR DDAH1 CYGB WASL DDAH2 NOSTRIN DNM2 ZDHHC21 HSP90AA1 LYPLA1 NOSIP VLDL ASSEMBLY%REACTOME%R-HSA-8866423.3 VLDL assembly P4HB MTTP APOB APOC4 APOC1 ZINC EFFLUX AND COMPARTMENTALIZATION BY THE SLC30 FAMILY%REACTOME DATABASE ID RELEASE 72%435368 Zinc efflux and compartmentalization by the SLC30 family SLC30A7 SLC30A6 SLC30A8 SLC30A3 SLC30A2 SLC30A5 SLC30A1 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS%REACTOME%R-HSA-163125.2 Post-translational modification: synthesis of GPI-anchored proteins BST1 PIGS CPM LY6K PIGU PIGT PGAP1 PIGO PSCA PIGN VNN1 GPAA1 VNN2 PIGP PIGZ MSLN PIGW PIGV PIGY PRSS21 PIGX FCGR3B PRND FOLR2 TECTA TECTB CD52 PLAUR RTN4RL2 IZUMO1R ALPPL2 PIGC DPM1 DPM2 PIGB DPM3 NRN1L CEACAM7 RTN4RL1 CD109 PIGA CEACAM5 LY6D PIGK SPACA4 PIGM PIGL LY6H PIGG PIGF GPLD1 LY6E PIGH NRN1 MFI2 NTM TEX101 LYPD1 LYPD2 LYPD3 THY1 ALPI LYPD4 LYPD5 ART3 ART4 OTOA LY6G6C LY6G6D OPCML NTNG1 NTNG2 NEGR1 CNTN5 GP2 LSAMP PLET1 VNN3 XPNPEP2 RAET1G LYPD6B RAET1L ALPL GPIHBP1 CNTN3 CNTN4 ULBP2 MDGA2 MDGA1 RECK SPRN BLOCH PATHWAY%REACTOME DATABASE ID RELEASE 72%6807047 Bloch pathway DHCR7 EBP DHCR24 SC5D DEFECTIVE ALG2 CAUSES ALG2-CDG (CDG-1I)%REACTOME%R-HSA-4549349.1 Defective ALG2 causes ALG2-CDG (CDG-1i) ALG2 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT)%REACTOME%R-HSA-917729.1 Endosomal Sorting Complex Required For Transport (ESCRT) TSG101 VPS4B VPS4A MVB12B MVB12A VPS36 VTA1 VPS37C VPS37D CHMP2A VPS37A STAM SNF8 VPS37B CHMP2B CHMP4C UBAP1 CHMP4B UBA52 HGS CHMP3 CHMP4A CHMP6 VPS25 STAM2 CHMP7 VPS28 CHMP5 UBB UBC RPS27A ACTIVATED NTRK3 SIGNALS THROUGH RAS%REACTOME%R-HSA-9034864.1 Activated NTRK3 signals through RAS HRAS SOS1 NTF3 NRAS NTRK3 MITOCHONDRIAL TRANSLATION ELONGATION%REACTOME%R-HSA-5389840.1 Mitochondrial translation elongation MRPL39 MRPL36 MRPL37 MRPL34 MRPL35 MRPL32 MRPL33 MRPL4 MRPL41 MRPL3 MRPL42 MRPL2 MRPL1 MRPL40 MRPL9 CHCHD1 MRPS28 TSFM MRPS26 MRPS27 MRPS24 MRPS25 MRPS22 MRPS23 MRPL49 MRPS18B MRPS2 MRPS18A MRPL47 MRPL48 MRPL45 MRPS7 MRPL46 MRPS6 MRPS5 MRPL43 MRPS18C TUFM MRPL44 MRPL52 OXA1L MRPL53 MRPL50 MRPS9 MRPL51 AURKAIP1 DAP3 MRPS35 MRPS36 MRPL18 MRPS33 MRPL19 MRPS34 MRPL16 MRPS31 MRPL17 MRPL14 MRPL15 MRPS30 MRPL12 MRPL57 MRPL13 MRPL10 MRPL54 MRPL55 MRPL11 MRPL20 ICT1 GADD45GIP1 PTCD3 MRPL27 MRPL28 ERAL1 MRPL23 MRPL24 MRPL21 MRPL22 MRPL30 MRPS17 MRPS15 GFM1 MRPS16 MRPS14 MRPS11 MRPS12 MRPL38 MRPS10 ION CHANNEL TRANSPORT%REACTOME%R-HSA-983712.2 Ion channel transport ANO3 ANO1 CAMK2D SGK3 CAMK2A SGK2 STOML3 ATP10D ATP10B RAF1 ATP10A ATP2C2 ATP2C1 CLCN3 CAMK2G CLCN2 CLCN1 BSND STOM ANO10 ATP9B ATP9A SLC17A3 MCOLN3 TRPA1 ATP13A1 WWP1 MCOLN2 TPCN2 TPCN1 CLCN7 CLCN6 CLCN5 CLCN4 OSTM1 ATP13A4 ATP13A5 ATP13A2 UNC79 SLN TCIRG1 PDZD11 ATP6V1E1 ATP6V1E2 ATP6V1G1 ATP6V0B ATP6V0E1 ATP6V1G2 ATP6AP1 ATP1B3 ATP1B2 ATP6V1B2 ATP6V0C ATP1B1 ATP6V0D2 ATP6V1B1 ATP6V1A ATP6V0A2 ATP6V1H ATP6V0A4 ATP6V0E2 ATP6V1G3 ATP6V1D ATP6V1C1 ATP6V1F ATP6V0A1 ATP6V1C2 MCOLN1 FXYD4 FXYD3 FXYD2 FXYD1 FXYD7 FXYD6 RYR1 RYR2 ATP2A3 ATP2A2 ATP2A1 RYR3 CLIC2 TRPC1 TRDN ASPH ATP1A4 ATP1A3 TRPC7 ATP1A2 ATP1A1 TRPC6 SRI TRPC3 PLN ATP2B4 ATP2B3 ATP2B2 UBA52 ATP2B1 FKBP1B UBB UBC RPS27A SGK1 ATP8A2 ATP8A1 ATP12A BEST2 SLC9C1 BEST3 SLC9C2 BEST1 BEST4 ATP11C ATP11B ATP11A TRPC4AP SLC9B1 SLC9B2 SCNN1G SCNN1D SCNN1B SCNN1A TTYH3 TTYH2 CLCNKB WNK4 NEDD4L CLCNKA NALCN TRPM1 TRPM2 ASIC4 ASIC5 CLCA2 CLCA1 TRPM7 TRPM8 ASIC2 TRPM5 ASIC3 TRPM6 CLCA4 TRPM3 ASIC1 TRPM4 ATP8B4 ATP8B3 ATP8B2 ATP8B1 TRPV2 TRPV3 TRPV1 ATP4B ATP4A TRPV6 WNK1 TRPV4 WNK2 TRPV5 WNK3 CUTC UNC80 ATP7B ATP7A TRPC5 TRPC4 TSC22D3 ANO8 ANO9 ANO6 ANO7 ANO4 ANO5 ATP6V0D1 ANO2 CAMK2B SYNTHESIS OF LIPOXINS (LX)%REACTOME DATABASE ID RELEASE 72%2142700 Synthesis of Lipoxins (LX) LTC4S PTGR1 ALOX12 ALOX5AP HPGD ALOX5 VIRAL MESSENGER RNA SYNTHESIS%REACTOME%R-HSA-168325.4 Viral Messenger RNA Synthesis GTF2F1 GTF2F2 POLR2A NUP85 POLR2B TPR POLR2C POLR2D NUP88 POLR2G NUP43 POLR2E POLR2F RAE1 POLR2H POLR2I POLR2J RANBP2 NUP107 NUP155 NUP188 POLR2K POLR2L NUP153 NUP62 NUP35 NUPL2 NDC1 NUP214 SEC13 NUP37 NUP133 NUP210 NUP93 NUP50 NUP54 POM121 NUP205 AAAS NUP160 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION%REACTOME DATABASE ID RELEASE 72%975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7 8 or 9 activation CUL1 MAP2K1 MAPKAPK3 UBA52 MAPK8 PPP2R1B ATF1 PPP2R1A APP ATF2 NFKBIA IKBKG ELK1 RELA RPS6KA3 RPS6KA5 RPS6KA2 RPS6KA1 DUSP4 PPP2R5D MEF2A MEF2C DUSP3 FOS VRK3 UBB DUSP6 DUSP7 UBC CREB1 MAPKAPK2 RPS27A MAPK7 MAPK1 MAPK3 PPP2CA HMGB1 PPP2CB IKBKB NKIRAS1 NKIRAS2 MAPK14 MAP3K8 MAP2K3 CHUK MAPK11 MAP2K4 RIPK2 IRAK4 PELI1 UBE2N TLR9 TLR8 TLR7 UBE2V1 PELI3 PELI2 NOD1 NFKB1 NOD2 NFKB2 AGER MAPK9 IRAK1 MAP2K6 S100A12 MAP2K7 MAP3K1 S100B MAPK10 TNIP2 JUN SAA1 MYD88 NFKBIB FBXW11 BTRC ECSIT SKP1 IRAK2 TRAF6 TICAM2 TAB3 LY96 TAB2 TICAM1 TAB1 MAP3K7 CD14 TLR4 TFAP2 (AP-2) FAMILY REGULATES TRANSCRIPTION OF OTHER TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 72%8866906 TFAP2 (AP-2) family regulates transcription of other transcription factors TFAP2A TFAP2C CITED2 PITX2 SIGNALING BY EGFR%REACTOME DATABASE ID RELEASE 72%177929 Signaling by EGFR PAG1 SH3GL1 ADAM10 EPS15L1 PTPN12 EPN1 ADAM12 PTPN11 SPRY2 SPRY1 ARHGEF7 PTPN3 STAM EGF SHC1 PXN GAB1 PIK3R1 CBL EGFR UBA52 PIK3CA HGS CDC42 PLCG1 SOS1 SH3GL3 STAM2 HRAS SH3GL2 BTC EPGN TGFA AREG NRAS UBB ADAM17 HBEGF EREG UBC RPS27A SH3KBP1 SRC PTPRK LRIG1 CSK EPS15 AAMP NONSENSE-MEDIATED DECAY (NMD)%REACTOME DATABASE ID RELEASE 72%927802 Nonsense-Mediated Decay (NMD) RPL26 RPL29 RPL10L RPS4X RPL10A RPL28 RPS3A RPL23A FAU RPL41 RPL3L PPP2R1A RPL10 RPL12 RPL13A RPL11 RPS3 RPL14 RPL13 NCBP1 NCBP2 RPS2 RPL15 RPL18 PPP2CA RPL17 RPL19 RPL27A RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS15 RPS14 RPS17 RPS16 RPS19 RPL18A RPL36AL RPS18 RPLP1 RPS11 RPS10 RPLP0 RPS13 RPS12 RPLP2 RPL7A RPS27L PABPC1 UBA52 RPL37A RPS26 RPS25 PPP2R2A RPS28 GSPT2 GSPT1 RPS27 UPF3A RPL36A SMG1 RPS29 SMG9 SMG7 RPS20 SMG8 RPL35A RPS21 SMG5 RPS24 SMG6 RPS23 UPF2 UPF1 ETF1 PNRC2 RPL22L1 RPS4Y2 RPS4Y1 RPS27A EIF4A3 CASC3 MAGOH DCP1A EIF4G1 RPL26L1 RPL4 RPL39L RBM8A RPL5 RPL30 RPL3 RPL32 RPL31 RPL34 RPL8 RPL9 RPL6 RPL7 UPF3B MAGOHB RPL36 RNPS1 RPL35 RPL38 RPL37 RPL39 RPS15A RPL21 RPL23 RPL22 RPL24 RPL27 AXONAL GROWTH STIMULATION%REACTOME DATABASE ID RELEASE 72%209563 Axonal growth stimulation NGFR ARHGDIA RHOA NGF SIGNALING BY PTK6%REACTOME DATABASE ID RELEASE 72%8848021 Signaling by PTK6 AKT1 ELMO1 ELMO2 CRK DOCK1 PXN UBA52 SOCS3 UBB BCAR1 CCND1 UBC RPS27A LRRK2 NR3C1 ARHGAP35 PELP1 NRG1 ARAP1 NRG2 DOK1 SFPQ CCNE1 NRG3 NRG4 KHDRBS1 KHDRBS2 KHDRBS3 EPAS1 HIF1A EGF GPNMB STAP2 PTPN1 CBL SRMS EGFR PTK6 CDK4 ERBB2 HRAS RASA1 BTC RHOA NRAS CDK2 HBEGF EREG CDKN1B STAT3 RAC1 INTERLEUKIN-6 FAMILY SIGNALING%REACTOME DATABASE ID RELEASE 72%6783589 Interleukin-6 family signaling STAT1 IL11 CNTFR CNTF PTPN11 IL6 IL31 CTF1 IL11RA LIF SOCS3 OSM IL31RA LIFR TYK2 OSMR CLCF1 JAK2 IL6ST CBL IL6R CRLF1 JAK1 STAT3 G-PROTEIN BETA:GAMMA SIGNALLING%REACTOME%R-HSA-397795.3 G-protein beta:gamma signalling PDPK1 GNG11 AKT1 GNG13 GNB2 GNB1 GNB4 GNB3 GNB5 PIK3CG GNGT1 GNGT2 CDC42 PAK1 GNG3 GNG2 RHOA PLCB3 PIK3R6 GNG5 PIK3R5 GNG4 GNG7 GNG8 PLCB1 PLCB2 AKT2 AKT3 BTK ARHGEF6 GNG10 GNG12 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL%REACTOME%R-HSA-209560.1 NF-kB is activated and signals survival IKBKB NGFR UBB UBC NFKB1 RPS27A UBA52 IRAK1 TRAF6 SQSTM1 NFKBIA NGF RELA ARL13B-MEDIATED CILIARY TRAFFICKING OF INPP5E%REACTOME%R-HSA-5624958.1 ARL13B-mediated ciliary trafficking of INPP5E ARL13B PDE6D INPP5E RHO GTPASES ACTIVATE IQGAPS%REACTOME%R-HSA-5626467.1 RHO GTPases activate IQGAPs CDH1 IQGAP2 IQGAP3 CDC42 MEN1 CTNNA1 CLIP1 RAC1 CTNNB1 IQGAP1 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB%REACTOME%R-HSA-3359471.1 Defective MMAB causes methylmalonic aciduria type cblB MMAB TRIGLYCERIDE METABOLISM%REACTOME%R-HSA-8979227.1 Triglyceride metabolism PNPLA4 PNPLA5 GPAM PPP1CC MOGAT3 MOGAT2 MOGAT1 GK2 LPIN1 LPIN2 LPIN3 FABP12 PPP1CB PRKACG PRKACA PRKACB DGAT2 GK FABP9 DGAT1 FABP1 FABP2 FABP3 FABP4 PLIN3 CAV1 FABP5 AGMO PLIN1 LIPE FABP6 FABP7 GPD2 MGLL ABHD5 GPAT2 PPP1CA CONSTITUTIVE SIGNALING BY LIGAND-RESPONSIVE EGFR CANCER VARIANTS%REACTOME%R-HSA-1236382.1 Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants HRAS NRAS UBB EGF SHC1 UBC GAB1 PIK3R1 CBL EGFR RPS27A UBA52 PIK3CA PLCG1 SOS1 HSP90AA1 CDC37 MTF1 ACTIVATES GENE EXPRESSION%REACTOME DATABASE ID RELEASE 72%5660489 MTF1 activates gene expression MTF1 CSRP1 SNCB SUMOYLATION OF TRANSCRIPTION COFACTORS%REACTOME DATABASE ID RELEASE 72%3899300 SUMOylation of transcription cofactors SUMO2 ING2 PIAS4 PIAS3 SIN3A PIAS1 NCOA1 NPM1 NCOA2 TOPORS PPARGC1A CREBBP NCOR2 DDX5 ZNF131 ZNF350 EP300 UHRF2 CTBP1 HIPK2 PARK7 BMI1 RNF2 TRIM28 NRIP1 UBE2I CBX8 DDX17 PHC2 PHC1 RING1 CBX4 CBX2 PCGF2 MBD1 MKL1 SAFB PHC3 SUMO1 DAXX SUMO3 AKT-MEDIATED INACTIVATION OF FOXO1A%REACTOME%R-HSA-211163.1 AKT-mediated inactivation of FOXO1A AKT1 AKT2 AKT3 FOXO1 CD28 DEPENDENT VAV1 PATHWAY%REACTOME DATABASE ID RELEASE 72%389359 CD28 dependent Vav1 pathway CD80 PAK2 CD28 VAV1 CDC42 PAK1 FYN RAC1 CD86 PAK3 LCK ESTROGEN-DEPENDENT NUCLEAR EVENTS DOWNSTREAM OF ESR-MEMBRANE SIGNALING%REACTOME%R-HSA-9634638.1 Estrogen-dependent nuclear events downstream of ESR-membrane signaling AKT1 FOXO3 UHMK1 PTK2 BCL2 BTC EPGN TGFA FOS AREG HBEGF EREG EGF CCND1 CDKN1B CREB1 EGFR AKT2 AKT3 SRF XPO1 MAPK1 ELK1 MAPK3 NON-CODING RNA METABOLISM%REACTOME DATABASE ID RELEASE 72%194441 Non-coding RNA Metabolism PRMT5 NUP107 TGS1 NUP188 NUP62 NDC1 NUP214 SEC13 NUP133 NUP210 NUP93 NUP50 NUP54 POM121 NUP205 NCBP1 NCBP2 AAAS NUP160 NUP85 TPR NUP88 NUP43 RAE1 RANBP2 NUP155 NUP153 GEMIN2 NUP35 PHAX NUPL2 SNRPD2 SNRPD1 SNRPD3 NUP37 CLNS1A SNRPG GEMIN4 GEMIN5 SNRPE GEMIN6 GEMIN7 SNRPF GEMIN8 SNRPB DDX20 SMN2 SMN1 SNUPN WDR77 PROLACTIN RECEPTOR SIGNALING%REACTOME%R-HSA-1170546.1 Prolactin receptor signaling CUL1 PTPN11 STAT5A STAT5B JAK2 CSH1 BTRC PRL SKP1 PRLR GHR RBX1 GH2 GH1 ZINC TRANSPORTERS%REACTOME DATABASE ID RELEASE 72%435354 Zinc transporters SLC39A10 SLC39A14 SLC39A6 SLC39A5 SLC39A8 SLC39A7 SLC39A2 SLC39A1 SLC39A4 SLC39A3 SLC30A7 SLC30A6 SLC30A8 SLC30A3 SLC30A2 SLC30A5 SLC30A1 DEFECTIVE SLC39A4 CAUSES ACRODERMATITIS ENTEROPATHICA, ZINC-DEFICIENCY TYPE (AEZ)%REACTOME DATABASE ID RELEASE 72%5619088 Defective SLC39A4 causes acrodermatitis enteropathica, zinc-deficiency type (AEZ) SLC39A4 G1 S TRANSITION%REACTOME DATABASE ID RELEASE 72%69206 G1 S Transition RBBP4 CUL1 RPA1 POLE RPA2 RPA3 RBL2 CCNA2 CCNA1 TFDP1 RBL1 PPP2R1B TFDP2 PPP2R1A POLE4 E2F1 E2F4 POLE2 POLE3 CCND1 DHFR PPP2CA PPP2CB CDK4 CDKN1A CDKN1B AKT2 PSMD8 AKT3 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 AKT1 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 CCNH PSME1 PSME2 RRM2 UBA52 PSMD10 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 CCNB1 UBB PSMB3 UBC CDK1 PSMB1 PSMF1 RPS27A RB1 SHFM1 GMNN TYMS MYC PSMB8 FBXO5 PSMB9 SKP2 PSMC5 CDC25A PSMC6 MAX PSMC3 ORC5 PSMC4 ORC4 PSMC1 ORC6 CDK7 PSMC2 ORC1 ORC3 ORC2 CDT1 CCNE2 CDC7 CDC6 MNAT1 CCNE1 POLA1 POLA2 LIN54 MCM7 MCM8 MCM10 CKS1B LIN52 DBF4 MCM3 MCM4 MCM5 PTK6 MCM6 MCM2 PRIM2 LIN37 PRIM1 LIN9 CDC45 E2F5 TK1 E2F6 CABLES1 PPP2R3B WEE1 RPA4 CDK2 SKP1 HDAC1 PCNA RUNX3 REGULATES CDKN1A TRANSCRIPTION%REACTOME%R-HSA-8941855.1 RUNX3 regulates CDKN1A transcription ZFHX3 TGFB1 SMAD3 SMAD4 RUNX3 TP53 CDKN1A SIGNALING BY OVEREXPRESSED WILD-TYPE EGFR IN CANCER%REACTOME DATABASE ID RELEASE 72%5638302 Signaling by Overexpressed Wild-Type EGFR in Cancer EGFR BTC EPGN TGFA AREG HBEGF EREG EGF PEPTIDE HORMONE METABOLISM%REACTOME DATABASE ID RELEASE 72%2980736 Peptide hormone metabolism LHB STX1A VAMP2 CTSZ PCSK2 PCSK1 UCN ERO1LB GNAT3 ERO1L KIF5C KIF5B ANPEP KIF5A FFAR4 CTSG CTSD LEP CTNNB1 CPA3 MME EXOC8 EXOC7 ATP6AP2 C9orf3 PAX6 MYRIP SLC30A7 ISL1 SLC30A6 ACE2 SLC30A8 EXOC4 EXOC3 EXOC6 SLC30A5 EXOC5 CRHR2 TSHB EXOC2 GCG EXOC1 CPB2 ENPEP CPB1 GRP GNG13 GPR119 PLA2G7 CGA DPP4 TMEM27 SEC11A SEC11C TCF7L2 ACE GNB3 CDX2 CMA1 MYO5A AGT INS RAB27A INHBB ACHE INHBA MBOAT4 IGF1 KLF4 INHBC GATA4 INHBE GZMH SPCS3 SPCS2 FSHB SPCS1 CPE REN POMC INHA GIP FFAR1 BCHE GH1 CES1 DEFECTIVE CYP1B1 CAUSES GLAUCOMA%REACTOME%R-HSA-5579000.1 Defective CYP1B1 causes Glaucoma CYP1B1 DEFECTIVE SLC17A8 CAUSES AUTOSOMAL DOMINANT DEAFNESS 25 (DFNA25)%REACTOME DATABASE ID RELEASE 72%5619076 Defective SLC17A8 causes autosomal dominant deafness 25 (DFNA25) SLC17A8 DEFECTIVE SLC5A7 CAUSES DISTAL HEREDITARY MOTOR NEURONOPATHY 7A (HMN7A)%REACTOME DATABASE ID RELEASE 72%5619114 Defective SLC5A7 causes distal hereditary motor neuronopathy 7A (HMN7A) SLC5A7 LGI-ADAM INTERACTIONS%REACTOME%R-HSA-5682910.2 LGI-ADAM interactions CACNG8 LGI1 LGI4 CACNG2 LGI3 LGI2 CACNG3 ADAM22 STX1A ADAM11 CACNG4 STX1B ADAM23 DLG4 SUMOYLATION OF DNA METHYLATION PROTEINS%REACTOME DATABASE ID RELEASE 72%4655427 SUMOylation of DNA methylation proteins BMI1 RNF2 UBE2I CBX8 DNMT1 PHC2 PHC1 RING1 CBX4 CBX2 PCGF2 PHC3 DNMT3B SUMO1 DNMT3A DAP12 SIGNALING%REACTOME DATABASE ID RELEASE 72%2424491 DAP12 signaling HLA-E VAV2 PLCG2 PIK3R1 PIK3R2 PIK3CA PLCG1 SYK SOS1 FYN HRAS NRAS B2M PIK3CB TREM2 BTK KLRK1 GRAP2 KLRC2 TYROBP RAC1 LCP2 KLRD1 VAV3 LCK DEFECTIVE CHST6 CAUSES MCDC1%REACTOME%R-HSA-3656225.1 Defective CHST6 causes MCDC1 LUM KERA FMOD CHST6 PRELP OMD OGN TRANSCRIPTIONAL REGULATION BY E2F6%REACTOME DATABASE ID RELEASE 72%8953750 Transcriptional Regulation by E2F6 RBBP4 L3MBTL2 UXT CDC7 YAF2 PCGF6 CBX5 MGA RBBP7 RYBP EZH2 APAF1 EHMT2 SUZ12 RRM2 TFDP1 TFDP2 E2F6 EED E2F1 RAD51 RBBP8 BMI1 RNF2 EPC1 PHC1 RING1 EHMT1 PCGF2 PHC3 CHEK1 BRCA1 CBX3 MAX BIOSYNTHESIS OF E-SERIES 18(S)-RESOLVINS%REACTOME DATABASE ID RELEASE 72%9018896 Biosynthesis of E-series 18(S)-resolvins ALOX15 LTA4H HPGD ALOX5 SUMOYLATION OF SUMOYLATION PROTEINS%REACTOME DATABASE ID RELEASE 72%4085377 SUMOylation of SUMOylation proteins SUMO2 NUP85 TPR NUP88 NUP43 RAE1 RANBP2 NUP107 NUP155 NUP188 PIAS4 NUP153 NUP62 NUP35 NUPL2 NDC1 NUP214 TOPORS SEC13 NUP37 NUP133 NUP210 NUP93 NUP50 UBE2I NUP54 POM121 NUP205 AAAS SUMO1 NUP160 REGULATION OF RUNX1 EXPRESSION AND ACTIVITY%REACTOME%R-HSA-8934593.1 Regulation of RUNX1 Expression and Activity TNRC6A TNRC6B MOV10 AGO3 AGO4 PTPN11 AGO1 AGO2 CBFB RUNX1 CCND3 CCND1 CCND2 CDK6 PML TNRC6C SRC MPS IIIA - SANFILIPPO SYNDROME A%REACTOME DATABASE ID RELEASE 72%2206307 MPS IIIA - Sanfilippo syndrome A SGSH ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS%REACTOME%R-HSA-390471.1 Association of TriC CCT with target proteins during biosynthesis SPHK1 CCT6A CCNE2 CCNE1 SKIV2L FBXL3 TP53 FBXL5 WRAP53 KIF13A CCT3 CCT2 TCP1 DCAF7 HDAC3 CCT6B USP11 GBA FBXO4 AP3M1 LONP2 FBXO6 GAPDHS FBXW4 FBXW5 CCT8 FBXW10 CCT7 FBXW7 CCT5 FBXW9 CCT4 NOP56 FBXW2 ARFGEF2 STAT3 XRN2 FKBP9 NUCLEOBASE CATABOLISM%REACTOME DATABASE ID RELEASE 72%8956319 Nucleobase catabolism NT5M GDA NUDT16 NT5C2 NUDT15 SAMHD1 GPX1 NT5C1A NT5C1B UPP2 UPP1 ITPA ENTPD1 ENTPD2 ENTPD3 ENTPD4 ENTPD5 ENTPD6 ENTPD7 ENTPD8 DPYD PNP NUDT5 ADPRM DNPH1 AGXT2 UPB1 XDH TYMP NT5C DPYS NT5E DEATH RECEPTOR SIGNALLING%REACTOME%R-HSA-73887.4 Death Receptor Signalling BAG4 NCSTN BCL2L11 CASP2 APH1B SHARPIN ECT2 ARHGEF33 ARHGEF35 ARHGEF37 ARHGEF39 ARHGEF38 GNB2L1 NET1 CYLD RASGRF2 OTUD7B TNFAIP3 ARHGEF10L AATF AKAP13 CASP3 MCF2L MAPK8 PSENEN ARHGEF11 ARHGEF10 ARHGEF12 PLEKHG2 ARHGEF15 ARHGEF17 PLEKHG5 ARHGEF16 RELA ARHGEF19 TRAF1 TNFRSF1A ARHGEF9 ARHGEF3 TAX1BP1 ARHGEF4 ARHGEF1 ARHGEF2 SOS2 ARHGEF5 BIRC2 BIRC3 ADAM17 RNF31 XIAP FGD1 FGD2 FGD3 GNA13 FGD4 LINGO1 USP21 MCF2 CFLAR OTULIN ITGB3BP IKBKB SMPD3 CHUK BAD RIPK2 SMPD2 NFKB1 IRAK1 MYD88 RAC1 TIAM2 VAV3 NGF CASP10 VAV1 VAV2 ARHGEF7 UBA52 TIAM1 NFKBIA IKBKG NGFR ARHGDIA UBB UBC RPS27A USP2 CASP8 TRADD TNFSF10 FAS TNFRSF10B FASLG RIPK1 TNFRSF10A TRAF2 SOS1 FADD TNFRSF10D HDAC3 TRIO ARHGEF18 PRDM4 SPPL2B ITSN1 SPPL2A TNF RHOA PREX1 ARHGEF40 PRKCI USP4 OMG CLIP3 MAG OBSCN HDAC2 NGFRAP1 RBCK1 NGEF YWHAE HDAC1 NSMAF ARHGEF26 TRAF6 ARHGEF6 MAGED1 TAB3 SQSTM1 PSEN2 TAB2 PSEN1 TAB1 MAP3K7 KALRN RTN4 APH1A ABR RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE%REACTOME%R-HSA-76042.3 RNA Polymerase II Transcription Initiation And Promoter Clearance GTF2F1 TAF2 GTF2B GTF2F2 CDK7 GTF2A1 POLR2A GTF2A2 POLR2B TAF1 POLR2C GTF2E1 POLR2D GTF2E2 POLR2G POLR2E MNAT1 POLR2F POLR2H POLR2I POLR2J AK6 POLR2K CCNH POLR2L GTF2H1 GTF2H2 GTF2H3 GTF2H4 TAF9B GTF2H5 TBP ERCC3 ERCC2 TAF9 TAF1L TAF15 TAF12 TAF13 TAF4B TAF10 TAF11 TAF7 TAF6 TAF5 TAF7L TAF4 TAF3 REGULATION OF TP53 ACTIVITY%REACTOME%R-HSA-5633007.3 Regulation of TP53 Activity EXO1 RBBP4 RPA1 RPA2 TOPBP1 WRN RPA3 ZNF385A DNA2 RFC5 RFC3 RBBP7 RFC4 MTA2 RFC2 PPP2R5C MBD3 CCNA2 CCNA1 PPP2R1B PPP2R1A GATAD2B TMEM55B GATAD2A PRKAA1 RNF34 PRKAA2 CSNK2A1 TAF9 TAF1L CSNK2A2 AURKB AURKA TP53INP1 RBBP8 RFFL CSNK2B TAF15 TAF12 TAF13 TAF10 TP53RK TAF11 EHMT1 NOC2L SSRP1 PML KAT5 RAD50 CHEK2 CHEK1 PIP4K2A PIP4K2B TAF7 PIP4K2C TAF6 TP63 TAF5 DAXX TAF4 PRKAB2 TAF3 HUS1 PPP2CA TAF2 PRKAB1 PPP2CB TAF1 TP53 RHNO1 L3MBTL1 MEAF6 NUAK1 BRIP1 TP53BP2 ATRIP BANP BARD1 PLK3 TPX2 PRR5 RAD17 ATM TP73 ATR SETD8 SETD9 AKT2 PHF20 AKT3 PRKAG1 MLST8 PRKAG2 BRCA1 PRKAG3 TAF7L ING5 PDPK1 AKT1 ING2 PRMT5 BRD1 RMI2 RMI1 TOP3A MAPKAP1 EHMT2 UBA52 TAF9B RICTOR BRD7 CHD4 CDKN2A MRE11A HIPK1 POU4F1 EP300 POU4F2 MTOR HIPK2 TTC5 CCNG1 UBB RAD1 UBC CDK1 RPS27A PRDM1 SGK1 STK11 NBN SUPT16H USP7 USP2 MAPK14 MAPK11 CDK5 KAT6A MAPKAPK5 AK6 SMYD2 CDK5R1 CHD3 MAP2K6 BRPF1 BRPF3 TBP JMY CDK2 MDM2 TAF4B PIN1 MDM4 RAD9B HDAC2 RAD9A HDAC1 DYRK2 PPP1R13B BLM PPP1R13L ACTIVATION OF TRKA RECEPTORS%REACTOME%R-HSA-187015.2 Activation of TRKA receptors ADCYAP1R1 ADORA2A NTRK2 NTRK1 ADCYAP1 NGF NEURODEGENERATIVE DISEASES%REACTOME%R-HSA-8863678.1 Neurodegenerative Diseases CAST BCL2L11 CDC25C CDC25B LMNB1 FOXO3 GOLGA2 CAPNS1 CAPNS2 CDK5 CAPN2 CAPN1 CDK5R1 PRDX2 SOD2 FASLG PRDX1 YWHAE APP JUN CDC25A CHROMATIN ORGANIZATION%REACTOME DATABASE ID RELEASE 72%4839726 Chromatin organization TAF9 TAF12 TAF10 GPS2 CARM1 RPS2 EHMT2 ARID4B ACTB SAP130 HIST1H2AE HIST1H2AD SMARCD3 HIST3H2BB HIST1H2AC HIST1H2AB HIST1H2AJ SAP30 HIST2H3A HIST1H2BF HIST1H2BE HIST1H2BH HIST1H2BG HIST2H3D HIST1H2BB HIST1H2BA HIST2H3C HIST1H2BD HIST1H2BC H2AFB1 HIST1H3J HIST1H3A HIST1H3F HIST1H3G HIST1H3H ACTL6A HIST1H3I SUDS3 HIST1H3B HIST1H3C HIST1H3D HIST1H3E HIST1H4K HIST1H4L HIST1H4A HIST1H4B HIST1H4H MCRS1 HIST1H4I HIST1H4J HIST1H4C HIST1H4D HIST1H4E EZH2 HIST1H4F HIST2H2AA3 HIST2H2AA4 RUVBL1 SUV39H1 CHD3 HIST2H2AC H2AFJ EED H2AFZ NCOR2 DNMT3A H2AFX NCOR1 HDAC3 H2AFV SUV420H2 SMARCB1 HDAC10 HIST2H2BE TRRAP KAT2B SUV420H1 KAT2A KAT8 AEBP2 EPC1 KAT7 HIST4H4 SUPT20H ATXN7L3 CSRP2BP SMARCC1 SMARCC2 HCFC1 HIST1H2BN JMJD6 HIST1H2BM WDR77 HDAC2 PADI3 HIST1H2BO PADI2 HIST1H2BJ PADI4 HDAC1 PADI1 PADI6 HIST1H2BI PRDM16 HIST1H2BL SETDB1 HIST1H2BK SETD1B SETD1A HIST2H4A SETDB2 MINA HIST2H4B SMARCA2 MTA1 SMARCA4 WHSC1 RBBP4 TADA2B ZZZ3 TADA2A PHF2 TBL1X SAP30L SUV39H2 SETD2 SETD3 SETD6 SETD7 SAP18 HIST2H2AB ASH2L RBBP7 IKBKAP MTA2 PHF8 ING4 MTA3 ING3 MECOM JAK2 MBD3 PRMT6 SUZ12 PBRM1 PRMT7 ACTL6B PRMT3 PAX3 TBL1XR1 ASH1L HIST2H2BF GATAD2B KDM4A SUPT3H KDM4B TAF6L GATAD2A CCDC101 CLOCK DOT1L RELA NSD1 BRD8 ELP2 ELP3 ELP4 ELP5 ELP6 HIST3H2A PRDM9 KDM1A KDM1B JADE1 ARID4A JADE3 YEATS4 JADE2 CCND1 RUVBL2 HIST1H2AG ARID2 EHMT1 HIST1H2AA WHSC1L1 HIST1H2AM HIST1H2AL KAT5 KDM2A HIST1H2AI KDM2B HIST1H2AH HIST1H2AK ARID5B SUPT7L MORF4L1 BRMS1 KAT6B MORF4L2 HAT1 KMT2E KMT2D ENY2 KMT2A KMT2C KMT2B TAF5L PHF21A ATXN7 MBIP EP400 DMAP1 MEAF6 SMYD3 DR1 NFKB1 NFKB2 COPRS MRGBP YEATS2 CDK4 TADA3 TADA1 BRWD1 OGT NCOA1 KDM5A KDM5B KDM5C NCOA2 KDM5D CREBBP DPY30 VPS72 WDR5 HMG20B UTY KDM6A KDM6B MSL2 MSL3 ARID1A ARID1B MSL1 KDM7A SMARCD1 KDM3A SMARCD2 KDM3B HDAC8 RBBP5 SMARCE1 ATF7IP SETD8 KDM4C KDM4D PHF20 USP22 KANSL1 KANSL2 KANSL3 ING5 PRMT5 BRD1 PRMT1 ATF2 CHD4 EP300 REST KAT6A AK6 SMYD2 BRPF1 BRPF3 PHOSPHORYLATION OF PROTEINS INVOLVED IN G1 S TRANSITION BY ACTIVE CYCLIN E:CDK2 COMPLEXES%REACTOME DATABASE ID RELEASE 72%69200 Phosphorylation of proteins involved in G1 S transition by active Cyclin E:Cdk2 complexes CCNE2 RB1 CCNE1 CDK2 UCH PROTEINASES%REACTOME DATABASE ID RELEASE 72%5689603 UCH proteinases ACTR5 ACTR8 HIST2H2AB TFPT HIST3H2A KDM1B HIST1H2AG HIST1H2AA HIST1H2AM HIST1H2AL HIST1H2AI HIST1H2AH HIST1H2AK NEDD8 SMAD7 UCHL1 SENP8 BARD1 OGT UCHL3 UCHL5 USP15 FOXK2 FOXK1 MBD5 MBD6 ADRM1 ASXL1 ASXL2 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 NFRKB PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 UBA52 ACTB PSMD10 HIST1H2AE PSMB11 HIST1H2AD PSMD12 HIST1H2AC PSMD11 HIST1H2AB PSMD14 HIST1H2AJ PSMD13 PSMA7 PSMB10 INO80 PSMA8 PSMB6 PSMB7 BAP1 PSMB4 PSMB5 PSMB2 UBB PSMB3 UBC PSMB1 PSMF1 ACTL6A RPS27A SHFM1 PSMB8 PSMB9 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 MCRS1 YY1 HIST2H2AA3 HIST2H2AA4 RUVBL1 HIST2H2AC INO80C INO80B INO80E INO80D TGFB1 TGFBR1 TGFBR2 HCFC1 BIOSYNTHESIS OF PROTECTIN AND RESOLVIN CONJUGATES IN TISSUE REGENERATION (PCTR AND RCTR)%REACTOME%R-HSA-9026766.1 Biosynthesis of protectin and resolvin conjugates in tissue regeneration (PCTR and RCTR) LTC4S LEISHMANIA INFECTION%REACTOME%R-HSA-9658195.1 Leishmania infection CASP1 PRKAR2B PRKAR2A HTR6 PLCG2 HTR7 GNAS HTR4 ADCY4 VIPR1 ADCY3 VIPR2 SCT ADCY2 RXFP1 ADCY1 RXFP2 ADCY8 ADCY7 IGHG4 ADCY6 CYSLTR1 GPR176 ADCY5 IGHG1 IGHG2 IGKV1-12 PTGDR LHCGR TAAR8 TAAR9 TAAR6 TAAR5 TAAR2 TAAR1 ADCYAP1 ADAM17 IGKV2D-28 IGKV4-1 IAPP ADCYAP1R1 CALCA CALCRL CALCB IGKV2D-30 GIPR GPR83 ADRB1 GPR84 ADRB2 CRHR1 CRHR2 GHRHR GCG MC2R CALCR HRH2 DRD1 IGKV3-11 DRD5 LYN CD163 GPR15 AVP YES1 IL6 MC1R RLN2 RLN3 GPR27 GPR25 GPR20 ADM CD3G PTH1R MC4R FCGR3A IGKV2-28 INSL3 IL10 GPR39 SYK FSHB GPR32 AVPR2 GLP2R RHBDF2 IGKV3D-20 GPBAR1 PTH2R GIP MC3R HCK ADORA2A ADRB3 ADORA2B FSHR CRH MYH9 NPSR1 PTGER4 RAMP2 RAMP3 GPR45 PTH PTGER2 PRKX PTH2 PTHLH NPS GPR150 C3 FCGR1A GPHA2 P2RY11 IGKV5-2 SCTR TSHR FCGR2A GHRH FURIN ADM2 MC5R VIP RAMP1 GPHB5 WIPF1 WIPF2 WIPF3 C3AR1 TXNIP MEFV NOX1 ARPC1B ARPC1A IL18 IL1A IL1B WAS NOXO1 MYO9B ACTG1 ACTB PYCARD NCKIPSD DVL1 NLRP3 DVL3 ARPC4 ARPC5 ARPC2 ARPC3 NOXA1 PSTPIP1 ACTR3 ACTR2 MYH2 MYO10 MYO1C GNAT3 SUGT1 GNAZ GNG10 GNG12 GNG11 GNG13 CGA GNB2 GNB1 GNB4 HSP90AB1 GNB3 GNB5 GNGT1 GNGT2 PLCG1 GNAI3 GNAI1 ABL1 GNAI2 GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 CYSLTR2 MAPK8 ENTPD1 PRKACG PRKACA PRKACB ENTPD5 RELA CTSG TSHB MYO5A WASL TXN NFKB1 NFKB2 POMC JUN PLK2 CYFIP2 CYFIP1 NCKAP1 AHCYL1 WNT5A BRK1 RAC1 NCK1 VAV3 PTGIR CYBA VAV1 VAV2 GGT1 FGR ELMO1 ELMO2 P2RX7 DPEP2 CRK LHB DPEP1 DOCK1 DPEP3 P2RX4 ITPR1 ITPR2 ITPR3 CDC42 NCKAP1L FYN WASF1 GGT5 WASF2 WASF3 DVL2 BAIAP2 FZD7 PTK2 ABI2 ABI1 CREB1 MAPK1 MAPK3 NT5E MAPK14 BTK ADCY9 GLP1R PRKAR1B PRKAR1A REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%R-HSA-186712.2 Regulation of beta-cell development MAML2 ONECUT3 AKT1 MAML1 ONECUT1 HNF4G RBPJ NEUROD1 HES1 NKX6-1 NKX2-2 PDX1 PAX4 HNF1B INS HNF1A MAFA SNW1 RFX6 MAML3 INSM1 PTF1A GCK MAMLD1 FOXA3 NEUROG3 FOXA2 FGF10 CREBBP EP300 KAT2B KAT2A SLC2A2 IAPP PAX6 AKT2 AKT3 FOXO1 NOTCH1 ACTIVATION OF HOX GENES DURING DIFFERENTIATION%REACTOME DATABASE ID RELEASE 72%5619507 Activation of HOX genes during differentiation CTCF RBBP4 PAGR1 RARA RARB MEIS1 ZNF335 POLR2E POLR2F POLR2H ASH2L RBBP7 POLR2K POLR2L SUZ12 PCGF2 PAX6 RQCD1 POLR2A POLR2B KMT2D POLR2C POLR2D POLR2G KMT2C POLR2I POLR2J JUN CREBBP NCOA6 WDR5 NCOA3 KDM6A RXRA RBBP5 AJUBA PAXIP1 HIST1H2AE HIST1H2AD HIST3H2BB HIST1H2AC HIST1H2AB HIST1H2AJ HIST2H3A HIST1H2BF HIST1H2BE HIST1H2BH EP300 HIST1H2BG HIST2H3D HIST1H2BB HIST1H2BA HIST2H3C HIST1H2BD HIST1H2BC H2AFB1 HIST1H3J HIST1H3A HIST1H3F HIST1H3G HIST1H3H HIST1H3I HIST1H3B HIST1H3C HIST1H3D HIST1H3E H3F3B HIST1H4K HIST1H4L H3F3A H2BFS EGR2 HIST1H4A HIST1H4B HIST1H4H HIST1H4I HIST1H4J HIST1H4C HIST1H4D HIST1H4E EZH2 HIST1H4F YY1 HIST2H2AA3 HIST2H2AA4 HIST2H2AC H2AFJ EED H2AFZ H2AFX CNOT6 NCOR1 HDAC3 H2AFV HIST2H2BE HIST4H4 HOXA3 HOXA2 HOXA1 HIST1H2BN PKNOX1 HIST1H2BM HOXA4 PIAS2 HIST1H2BO HOXB4 HIST1H2BJ HOXB3 HOXB2 HOXB1 HIST1H2BI HOXD1 HIST1H2BL HOXC4 HIST1H2BK PBX1 MAFB HIST2H4A HOXD4 HOXD3 HIST2H4B RARG COMPLEX I BIOGENESIS%REACTOME DATABASE ID RELEASE 72%6799198 Complex I biogenesis NDUFA7 NDUFA6 NDUFA5 NDUFA3 NDUFA2 NDUFA1 NDUFAF6 NDUFAF7 NDUFAF4 NDUFAF5 NDUFAF2 NDUFV3 NDUFV2 NDUFAF3 TMEM126B NDUFAF1 NDUFV1 MT-ND6 MT-ND4 MT-ND5 MT-ND2 MT-ND3 MT-ND1 NDUFS8 NDUFS7 NDUFS6 NDUFS5 NDUFS4 NDUFS3 NDUFAB1 NDUFS2 TIMMDC1 NDUFS1 NDUFC2 NDUFA13 NDUFC1 NDUFA11 NDUFA12 NDUFA10 NDUFB10 NDUFB11 NDUFB9 NDUFB8 ACAD9 NDUFB7 NDUFB6 NDUFB5 NDUFB4 NDUFB3 NDUFB2 NDUFB1 NUBPL ECSIT NDUFA9 NDUFA8 GOLGI ASSOCIATED VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 72%432722 Golgi Associated Vesicle Biogenesis VAMP2 OCRL TFRC AP4E1 ARRB1 CLINT1 FTH1 AP3S1 SH3GL2 SH3D19 PIK3C2A TPD52 AP3B1 GAK VAMP8 VAMP7 DNAJC6 FTL NAPA DNM2 RAB5C TGOLN2 BLOC1S4 BLOC1S6 SNX2 BLOC1S1 BLOC1S3 HSPA8 SNX9 SNX5 TXNDC5 TBC1D8B SNAPIN SORT1 DTNBP1 HIP1R PUM1 TPD52L1 AP4B1 IGF2R NECAP1 GOLGB1 CPD YIPF6 ACBD3 PICALM AP1G1 AP1S2 AP1B1 AP1S1 AP1S3 ARF1 AP1M2 AP1M1 PHOSPHATE BOND HYDROLYSIS BY NUDT PROTEINS%REACTOME DATABASE ID RELEASE 72%2393930 Phosphate bond hydrolysis by NUDT proteins NUDT16 NUDT15 ADPRM NUDT5 TELOMERE MAINTENANCE%REACTOME DATABASE ID RELEASE 72%157579 Telomere Maintenance LIG1 RPA1 RPA2 POLD3 RFC1 RTEL1 POLD4 WRN RPA3 POLD1 POLD2 RFC5 TINF2 DNA2 RFC3 TERF2IP RFC4 RFC2 DSCC1 CHTF18 OBFC1 DKC1 NHP2 HIST1H2AE PIF1 HIST1H2AD CHTF8 HIST3H2BB TERT HIST1H2AC GAR1 ACD HIST1H2AB CTC1 TEN1 HIST1H2AJ NOP10 HIST1H2BF HIST1H2BE HIST1H2BH HIST1H2BG HIST1H2BB HIST1H2BA HIST1H2BD HIST1H2BC H2AFB1 HIST3H3 RUVBL2 TERF1 TERF2 POT1 HIST1H4K HIST1H4L H2BFS HIST1H4A HIST1H4B HIST1H4H HIST1H4I HIST1H4J HIST1H4C POLA1 HIST1H4D POLA2 HIST1H4E HIST1H4F HIST2H2AA3 HIST2H2AA4 WRAP53 RUVBL1 HIST2H2AC PRIM2 H2AFJ PRIM1 H2AFZ H2AFX H2AFV HIST2H2BE HIST4H4 HIST1H2BN HIST1H2BM HIST1H2BO HIST1H2BJ HIST1H2BI HIST1H2BL HIST1H2BK HIST2H4A FEN1 BLM HIST2H4B PCNA THE ROLE OF NEF IN HIV-1 REPLICATION AND DISEASE PATHOGENESIS%REACTOME%R-HSA-164952.1 The role of Nef in HIV-1 replication and disease pathogenesis CD28 ELMO1 ATP6V1H FYN PAK2 CD4 HCK CD8B DOCK2 AP1G1 PACS1 AP1S2 AP1B1 AP1S1 AP1S3 ARF1 HLA-A B2M AP2A1 AP1M2 AP1M1 AP2B1 AP2A2 AP2S1 AP2M1 RAC1 LCK LOSS OF FUNCTION OF SMAD4 IN CANCER%REACTOME%R-HSA-3304347.1 Loss of Function of SMAD4 in Cancer SMAD2 SMAD3 SMAD4 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME DATABASE ID RELEASE 72%975163 IRAK2 mediated activation of TAK1 complex upon TLR7 8 or 9 stimulation UBB UBC RPS27A UBA52 IRAK2 TRAF6 TICAM2 TAB3 LY96 TAB2 TICAM1 TAB1 CD14 MAP3K7 TLR4 REGULATION OF PTEN STABILITY AND ACTIVITY%REACTOME%R-HSA-8948751.1 Regulation of PTEN stability and activity PSMD3 AKT1 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 UBA52 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 CSNK2A1 PSMA7 PSMB10 TRIM27 PSMA8 CSNK2A2 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 CSNK2B UBB PREX2 XIAP PSMB3 USP13 TNKS TNKS2 UBC PSMB1 WWP2 PSMF1 RNF146 STUB1 RPS27A FRK OTUD3 SHFM1 PSMB8 PSMB9 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 NEDD4 MKRN1 AKT2 PSMD8 AKT3 PSMD9 PSMD6 PTEN PSMD7 PSMD4 PSMD5 PSMD2 DEFECTIVE B3GAT3 CAUSES JDSSDHD%REACTOME%R-HSA-3560801.1 Defective B3GAT3 causes JDSSDHD SDC4 SDC2 SDC3 GPC1 GPC3 GPC2 BCAN GPC5 VCAN GPC4 GPC6 NCAN BGN HSPG2 CSPG5 CSPG4 B3GAT3 DCN SDC1 AGRN IRAK1 RECRUITS IKK COMPLEX%REACTOME DATABASE ID RELEASE 72%937039 IRAK1 recruits IKK complex PELI2 IKBKB IRAK1 CHUK TRAF6 UBE2N PELI1 IKBKG UBE2V1 PELI3 ACTIVATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%R-HSA-2485179.1 Activation of the phototransduction cascade GNGT1 CNGA1 RHO SAG PDE6B PDE6A CNGB1 GNB1 GNAT1 SLC24A1 PDE6G SIALIC ACID METABOLISM%REACTOME%R-HSA-4085001.2 Sialic acid metabolism ST3GAL4 ST3GAL6 NEU2 ST3GAL1 NEU3 ST3GAL2 NEU1 ST3GAL3 GLB1 ST6GALNAC1 ST6GALNAC2 CMAS NPL NANP ST6GALNAC6 NEU4 ST8SIA4 SLC17A5 ST8SIA5 ST3GAL5 ST8SIA6 NANS ST6GAL1 ST6GAL2 ST8SIA1 ST8SIA2 ST8SIA3 ST6GALNAC3 ST6GALNAC4 ST6GALNAC5 GNE SLC35A1 CTSA SIGNALING BY BRAF AND RAF FUSIONS%REACTOME%R-HSA-6802952.1 Signaling by BRAF and RAF fusions CAMK2D CAMK2A BCL2L11 MAP2K1 MAP2K2 BRAF RAF1 CAMK2G ITGA2B ARAF PEBP1 ARRB2 KIAA1549 MPRIP JAK2 TRIM24 KSR1 AGTRAP KSR2 SND1 APBB1IP CNKSR2 CNKSR1 PAPD7 ESRP1 CLCN6 VCL FAM114A2 ARRB1 ZC3HAV1 TRAK1 FXR1 RAP1B FGB ATG7 FGA MARK3 FN1 VWF QKI FAM131B AP3B1 AGGF1 RAP1A FGG MAPK1 MAPK3 IQGAP1 HRAS LMNA KDM7A PAPSS1 NRAS ITGB3 AKAP9 YWHAB SRC AGK CSK TLN1 CAMK2B MAPK6 MAPK4 SIGNALING%REACTOME DATABASE ID RELEASE 72%5687128 MAPK6 MAPK4 signaling PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 CCND3 PSME3 PSME4 PSME1 PSME2 UBA52 PSMD10 CDC42 PSMB11 PAK1 PSMD12 PRKACG PSMD11 PRKACA PSMD14 PRKACB PSMD13 PAK3 PSMA7 PSMB10 PAK2 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 UBB PSMB3 UBC PSMB1 CDK1 PSMF1 RPS27A CDC14A CDC14B TNRC6C SEPT7 RAG2 SHFM1 RAG1 FOXO1 MYC ETV4 PSMB8 CDC42EP5 PSMB9 CDC42EP3 PSMC5 CDC42EP2 PSMC6 DNAJB1 PSMC3 IGF2BP1 PSMC4 MAPK6 PSMC1 MAPK4 PSMC2 TNRC6A TNRC6B FOXO3 MAPKAPK5 JUN NCOA3 MOV10 AGO3 AGO4 AGO1 AGO2 HSPB1 PSMD8 PSMD9 PSMD6 XPO1 PSMD7 PSMD4 RAC1 KALRN PSMD5 PSMD2 MPS IIIB - SANFILIPPO SYNDROME B%REACTOME%R-HSA-2206282.2 MPS IIIB - Sanfilippo syndrome B NAGLU FRS-MEDIATED FGFR2 SIGNALING%REACTOME%R-HSA-5654700.3 FRS-mediated FGFR2 signaling HRAS FRS2 PTPN11 FRS3 FGF16 FGF7 FGF18 NRAS FGF6 FGF9 SOS1 FGF20 FGF1 FGF2 FGF23 FGF3 FGF22 FGF10 FGF4 DEFECTIVE OPLAH CAUSES 5-OXOPROLINASE DEFICIENCY (OPLAHD)%REACTOME DATABASE ID RELEASE 72%5578998 Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD) OPLAH FERTILIZATION%REACTOME%R-HSA-1187000.2 Fertilization CATSPER1 CATSPER3 CATSPER2 CATSPER4 HVCN1 ADAM21 B4GALT1 ADAM20 OVGP1 IZUMO3 IZUMO2 IZUMO4 IZUMO1 ADAM30 ADAM2 ACR KCNU1 CATSPERB CATSPERD CATSPERG CD9 ZP1 ZP3 ZP2 SPAM1 ZP4 APC:CDC20 MEDIATED DEGRADATION OF CELL CYCLE PROTEINS PRIOR TO SATISFATION OF THE CELL CYCLE CHECKPOINT%REACTOME DATABASE ID RELEASE 72%179419 APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 BUB1B CCNA2 CCNA1 UBA52 CDC20 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 ANAPC15 ANAPC16 PSMB6 ANAPC7 PSMB7 UBE2C UBE2E1 PSMB4 UBE2D1 ANAPC10 PSMB5 ANAPC11 PSMB2 UBB CDC23 PSMB3 CDC26 CDC27 UBC CDC16 PSMB1 CDK1 ANAPC4 PSMF1 ANAPC5 ANAPC1 RPS27A ANAPC2 SHFM1 PSMB8 PSMB9 PSMC5 PSMC6 PSMC3 PSMC4 BUB3 PSMC1 PSMC2 MAD2L1 NEK2 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 CARGO TRAFFICKING TO THE PERICILIARY MEMBRANE%REACTOME%R-HSA-5620920.2 Cargo trafficking to the periciliary membrane ARF4 PKD2 PKD1 BBS9 CNGA2 BBS7 CNGA4 BBS5 BBS4 MKKS CYS1 SSTR3 LZTFL1 BBS10 RP2 BBS12 UNC119B ARL6 ARL3 ASAP1 MCHR1 EXOC8 NPHP3 EXOC7 RAB11FIP3 BBS2 BBS1 RAB3IP BBIP1 RAB11A TTC8 EXOC4 NPHP3-ACAD11 EXOC3 EXOC6 EXOC5 EXOC2 EXOC1 GBF1 RHO CNGB1 INPP5E CCT3 CCT2 TCP1 RAB8A CCT8 CCT5 CCT4 SMO ARL13B PDE6D METABOLISM OF INGESTED MESEO2H INTO MESEH%REACTOME DATABASE ID RELEASE 72%5263617 Metabolism of ingested MeSeO2H into MeSeH TXNRD1 TRAF3 DEFICIENCY - HSE%REACTOME%R-HSA-5602571.2 TRAF3 deficiency - HSE TRAF3 TICAM1 TLR3 ALKBH2 MEDIATED REVERSAL OF ALKYLATION DAMAGE%REACTOME DATABASE ID RELEASE 72%112122 ALKBH2 mediated reversal of alkylation damage ALKBH2 DNA REPLICATION%REACTOME%R-HSA-69306.4 DNA Replication LIG1 CUL1 RPA1 POLE RPA2 POLD3 RFC1 POLD4 RPA3 POLD1 POLD2 DNA2 RFC5 RFC3 RFC4 RFC2 CCNA2 CCNA1 POLE4 E2F1 POLE2 POLE3 FZR1 E2F2 E2F3 GINS1 GINS2 GINS3 GINS4 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 UBA52 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 ANAPC15 ANAPC16 PSMB6 ANAPC7 UBE2C PSMB7 UBE2E1 PSMB4 UBE2D1 ANAPC10 PSMB5 ANAPC11 PSMB2 UBB CDC23 PSMB3 CDC26 CDC27 UBC CDC16 PSMB1 ANAPC4 PSMF1 ANAPC5 ANAPC1 RPS27A ANAPC2 SHFM1 GMNN PSMB8 PSMB9 SKP2 PSMC5 PSMC6 PSMC3 ORC5 PSMC4 ORC4 PSMC1 ORC6 PSMC2 ORC1 ORC3 ORC2 CDT1 CCNE2 CDC7 CDC6 CCNE1 POLA1 POLA2 MCM7 MCM8 MCM10 DBF4 MCM3 MCM4 MCM5 MCM6 MCM2 PRIM2 PRIM1 CDC45 RPA4 CDK2 SKP1 RBX1 FEN1 PCNA BETA OXIDATION OF MYRISTOYL-COA TO LAUROYL-COA%REACTOME%R-HSA-77285.2 Beta oxidation of myristoyl-CoA to lauroyl-CoA HADHB HADHA ACADL DEFECTIVE MISMATCH REPAIR ASSOCIATED WITH MSH6%REACTOME%R-HSA-5632968.1 Defective Mismatch Repair Associated With MSH6 MSH2 MSH6 NEURONAL SYSTEM%REACTOME DATABASE ID RELEASE 72%112316 Neuronal System GRIA2 CAMK2D PRKAR2B CAMK2A AKAP5 PRKAR2A GRIP1 SHARPIN CACNG8 EPB41L1 TSPAN7 MYO6 CACNG2 CAMK2G CACNG3 GRIA3 CACNG4 GRIA4 RASGRF2 PRKCG NSF DLG1 DLG4 PICK1 ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 PRKAA1 ADCY7 ADCY6 PRKAA2 ADCY5 GLS2 ARHGEF9 PLCB3 PLCB1 PLCB2 CHAT KCNS3 ACHE CACNA1A HRAS CACNA1E CACNB2 CACNB3 NRAS PRKX BCHE CAMK4 KCNJ11 GNAT3 GLUL GNG10 GNG12 GNG11 GNG13 MAOA GNB2 GNB1 GNB4 GNB3 GNB5 GNGT1 GNGT2 GNAI3 GNAI1 GNAI2 GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 ABAT RPS6KA6 ARL6IP5 HOMER3 ACTN2 GABRG3 CACNA2D2 GABRG2 KCNQ2 KCNQ3 KCNQ4 KCNQ5 PRKACG EPB41 GJC1 PRKACA EPB41L5 PRKACB GRIN2A EPB41L2 GJA10 EPB41L3 KCNN1 KCNN2 KCNN3 KCNN4 HOMER1 HOMER2 GRIN2C GRIN2B GRIN2D GRIN3B PPFIBP1 GRIN3A PPFIBP2 GABRB3 GABRB2 GABRB1 PTPRS KCNC1 ALDH2 GRIK5 KCNC3 KCNC4 GLS GRIK3 GRIK4 GRIK1 KCNH2 KCNK10 GRIK2 KIF17 SLC6A3 KCNK13 PTPRF CACNA2D3 SLC6A4 KCNC2 PANX1 GABRR3 PRKAB2 KCNK16 GABRR2 PANX2 KCNK17 PRKAB1 GABRR1 SIPA1L1 NEFL ABCC8 KCNK18 DLGAP1 DLGAP3 CACNB1 DLGAP2 GIT1 CACNB4 SLC18A3 KCNQ1 DLGAP4 DBNL SLC32A1 GJD2 ALDH5A1 LRRC7 KCNA1 KCNA2 KCNA3 KCNA4 KCNA5 CHRNA1 KCNA6 CHRNB2 KCNA7 CHRND CAMKK1 CHRNB4 CAMKK2 CHRNA3 BEGAIN CHRNB3 GLRA1 CHRNA2 GLRA2 CHRNA5 GLRA3 CHRNG SLC17A7 CHRNA4 CHRNE GABRA2 GABRQ CHRNA6 SLC5A7 GABRA1 GABBR2 GABBR1 GABRA6 GABRA5 KCNMB1 GABRA4 KCNMA1 KCNB2 KCNMB2 GAD1 KCNMB3 GABRA3 KCNMB4 GAD2 GRIN1 KCNS1 KCNK6 KCNS2 CAMK1 KCNK7 APBA3 KCNK9 APBA2 KCNG1 KCNG3 KCNG4 AP2A1 KCNH1 KCNH3 KCNH4 KCND1 SLC38A1 KCND2 KCNH5 PRKAG1 KCND3 KCNH6 KCNH7 PRKAG2 KCNH8 ABCC9 KCNB1 NAAA SRC RTN3 UNC13B PRKAG3 RAC1 CHRNA7 SLC1A1 SNAP25 RAB3A CHRNA9 PRKCB CACNA1B SYT1 KCNG2 CASK SLC1A2 PDPK1 SLC1A3 LIN7A SYN3 SLC1A6 LIN7C SLC1A7 CPLX1 KCNV1 LIN7B KCNV2 PRKCA SYN1 SLC38A2 SLC22A2 RIMS1 LRRC4B BZRAP1 KCNF1 KCNJ2 STXBP1 PPFIA1 SYT2 SLC22A1 APBA1 SYT9 KCNJ4 PPFIA4 SYT7 STX1A LRFN3 KCNJ12 SLC18A2 PTPRD VAMP2 LRFN2 PPFIA3 GNAL KCNJ14 PPFIA2 DLG2 LRFN4 NBEA DLG3 LRFN1 RASGRF1 GRM1 NRGN GRM5 LRRTM3 KCNK1 LRRTM4 KCNK2 LRRTM1 KCNK3 LRRTM2 KCNK4 NPTN FLOT1 NTRK3 RPS6KA3 FLOT2 HTR3E HTR3C RPS6KA2 HTR3D RPS6KA1 HTR3A KCNAB1 HTR3B KCNAB2 KCNAB3 LRTOMT DNAJC5 IL1RAPL2 IL1RAPL1 KCNA10 SHANK2 SHANK1 HCN4 NLGN3 HCN3 KPNA2 CREB1 NLGN1 KCNJ8 SLC6A13 NLGN2 SLC6A12 NRXN1 SLC6A11 NRXN3 SLC6A1 NRXN2 HSPA8 PPM1E PPM1F NCALD SLITRK2 SLITRK1 SLITRK4 MAPK1 SLITRK3 SLITRK6 MAPK3 SLITRK5 PDLIM5 KCNJ1 KCNJ3 NLGN4Y NRG1 KCNJ5 KCNJ6 KCNJ10 NLGN4X KCNJ9 KCNJ15 KCNJ16 GLRB SYT12 SYT10 HCN2 HCN1 COMT MDM2 ADCY9 PRKAR1B PRKAR1A GRIA1 CAMK2B GLOBAL GENOME NUCLEOTIDE EXCISION REPAIR (GG-NER)%REACTOME%R-HSA-5696399.1 Global Genome Nucleotide Excision Repair (GG-NER) SUMO2 LIG1 POLK RPA1 POLE RPA2 POLD3 NFRKB RFC1 POLD4 RNF111 ACTR5 RPA3 USP45 POLD1 RAD23A POLD2 RFC5 ACTR8 RFC3 RFC4 RAD23B DDB2 RFC2 CCNH XPA COPS7B XPC UBA52 COPS7A TFPT GTF2H1 ACTB GTF2H2 GTF2H3 GTF2H4 GTF2H5 ERCC3 ERCC2 XRCC1 INO80 CUL4A POLE4 ERCC4 ERCC1 POLE2 UBB POLE3 ERCC5 PARP1 UBC CUL4B PARP2 ACTL6A RPS27A DDB1 GPS1 CDK7 MCRS1 MNAT1 UBE2N YY1 RUVBL1 PIAS3 CETN2 LIG3 CHD1L PIAS1 UBE2V2 INO80C INO80B INO80E INO80D UBE2I COPS4 COPS3 COPS6 COPS5 COPS2 RBX1 COPS8 SUMO1 SUMO3 PCNA CERAMIDE SIGNALLING%REACTOME DATABASE ID RELEASE 72%193681 Ceramide signalling SMPD2 NGFR NGF REGULATED PROTEOLYSIS OF P75NTR%REACTOME DATABASE ID RELEASE 72%193692 Regulated proteolysis of p75NTR NCSTN NFKB1 APH1B PSENEN TRAF6 NGFR PSEN2 PSEN1 ADAM17 APH1A RELA POLO-LIKE KINASE MEDIATED EVENTS%REACTOME%R-HSA-156711.2 Polo-like kinase mediated events RBBP4 CDC25C EP300 PLK1 CENPF LIN54 CCNB1 LIN52 PKMYT1 FOXM1 MYBL2 LIN37 LIN9 CDC25A CCNB2 WEE1 SIGNALING BY MET%REACTOME DATABASE ID RELEASE 72%6806834 Signaling by MET RAPGEF1 SH3GL1 LAMA5 LAMA2 LAMA1 LAMA4 HPN LAMA3 LAMB3 PTPN11 LAMB2 RANBP9 CRK LAMB1 RANBP10 MUC20 PTPN2 STAM UBA52 HGS SH3GL3 STAM2 RAB4A RAP1B SH3GL2 GGA3 RAB4B HGF PTK2 MET CRKL RAP1A ARF6 UBB UBC RPS27A GAB1 PIK3R1 PTPN1 CBL PIK3CA SOS1 HRAS NRAS ITGB1 LAMC3 DOCK7 LAMC2 PTPRJ STAT3 SPINT2 LAMC1 SH3KBP1 TNS4 TNS3 SRC HGFAC RAC1 USP8 LRIG1 ITGA3 ITGA2 EPS15 SPINT1 TRANSPORT OF CONNEXINS ALONG THE SECRETORY PATHWAY%REACTOME DATABASE ID RELEASE 72%190827 Transport of connexins along the secretory pathway GJA1 GJB2 GJB1 INTRA-GOLGI TRAFFIC%REACTOME DATABASE ID RELEASE 72%6811438 Intra-Golgi traffic NAPG CYTH3 CYTH2 RAB41 GOLGA5 CYTH4 MAN2A2 CUX1 MAN1A2 MAN2A1 MAN1C1 STX6 VTI1A STX5 MAN1A1 SNAP29 YKT6 NSF CYTH1 COG8 RIC1 COG7 COG6 COG5 COG4 COG3 COG2 RAB39A COG1 BET1L GOSR2 RAB33B RGP1 RAB30 RAB36 ALPP TRIP11 VPS45 NAPA ARF1 NAPB STX16 GOSR1 GOLIM4 REGULATION OF IFNG SIGNALING%REACTOME%R-HSA-877312.2 Regulation of IFNG signaling PTPN6 JAK2 PTPN1 JAK1 PTPN11 SOCS1 IFNG PIAS1 IFNGR1 SOCS3 IFNGR2 SUMO1 ROLE OF SECOND MESSENGERS IN NETRIN-1 SIGNALING%REACTOME%R-HSA-418890.1 Role of second messengers in netrin-1 signaling TRPC7 PITPNA NTN1 TRPC6 TRPC3 TRPC5 PLCG1 TRPC4 TRPC1 DCC TP53 REGULATES TRANSCRIPTION OF ADDITIONAL CELL CYCLE GENES WHOSE EXACT ROLE IN THE P53 PATHWAY REMAIN UNCERTAIN%REACTOME DATABASE ID RELEASE 72%6804115 TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain CNOT6 PLK2 CNOT7 CDC25C RGCC TNKS1BP1 CNOT11 CNOT1 CENPJ CNOT6L CNOT2 CNOT3 TP53 BTG2 PLAGL1 CNOT8 RQCD1 PLK3 NPM1 CNOT10 CNOT4 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS%REACTOME DATABASE ID RELEASE 72%75876 Synthesis of very long-chain fatty acyl-CoAs ELOVL5 ELOVL2 ELOVL3 ACSF3 ELOVL6 HACD1 ELOVL7 ACSBG1 TECR ACSBG2 HSD17B3 HSD17B12 HACD3 HACD2 ACSL1 HACD4 ACSL6 ACSL5 ACSL4 SLC27A3 ACSL3 ELOVL1 TECRL ELOVL4 DEFECTIVE GNE CAUSES SIALURIA, NONAKA MYOPATHY AND INCLUSION BODY MYOPATHY 2%REACTOME%R-HSA-4085011.1 Defective GNE causes sialuria, Nonaka myopathy and inclusion body myopathy 2 GNE APOPTOTIC EXECUTION PHASE%REACTOME DATABASE ID RELEASE 72%75153 Apoptotic execution phase CDH1 PRKCD ROCK1 HMGB2 KPNA1 CASP7 FNTA CASP3 HIST1H1D HIST1H1E DNM1L SPTAN1 HIST1H1A HIST1H1B HIST1H1C DSP DFFB DFFA APC GAS2 DSG1 PAK2 PKP1 PRKCQ DSG2 MAPT DSG3 PLEC SATB1 PTK2 BCAP31 GSN BIRC2 TJP1 OCLN H1F0 STK24 CTNNB1 STK26 ACIN1 VIM TJP2 BMX KPNB1 HMGB1 LMNB1 DBNL CASP8 ADD1 CLSPN CASP6 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA%REACTOME%R-HSA-1234176.2 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 UBA52 PSMD10 TCEB2 PSMB11 TCEB1 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 VHL PSMB6 PSMB7 PSMB4 UBE2D1 PSMB5 PSMB2 UBB PSMB3 UBC PSMB1 PSMF1 RPS27A SHFM1 PSMB8 UBE2D2 PSMB9 UBE2D3 PSMC5 HIF3A PSMC6 LIMD1 PSMC3 CUL2 PSMC4 EGLN1 PSMC1 EGLN3 PSMC2 EGLN2 WTIP EPAS1 HIF1A AJUBA PSMD8 PSMD9 PSMD6 RBX1 PSMD7 PSMD4 PSMD5 PSMD2 ACTIVATION OF NOXA AND TRANSLOCATION TO MITOCHONDRIA%REACTOME DATABASE ID RELEASE 72%111448 Activation of NOXA and translocation to mitochondria PMAIP1 TFDP1 E2F1 TFDP2 TP53 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA%REACTOME%R-HSA-1834949.1 Cytosolic sensors of pathogen-associated DNA TRIM32 POLR2E POLR2F POLR2H POLR2K PRKDC POLR2L UBA52 XRCC6 NFKBIA IKBKG XRCC5 RELA MRE11A EP300 UBB CTNNB1 UBC RPS27A IRF3 TLR3 IKBKB NKIRAS1 NKIRAS2 CHUK NFKB1 NFKB2 RIPK1 MYD88 NFKBIB CREBBP CRCP DDX41 TBK1 LRRFIP1 TRIM21 MB21D1 ZBP1 RIPK3 TMEM173 IRF7 TRIM56 DHX9 POLR1C NLRC3 DTX4 IFI16 NLRP4 DHX36 STAT6 POLR3GL TREX1 POLR3A POLR3B POLR3C POLR3D TICAM1 POLR3E POLR3F POLR3G POLR3H POLR3K GSD 0%REACTOME%R-HSA-3858516.2 GSD 0 GYS2 GYG2 BIOSYNTHESIS OF MARESINS%REACTOME DATABASE ID RELEASE 72%9018682 Biosynthesis of maresins EPHX2 CYP3A4 CYP2C9 CYP1A2 CYP2C8 CYP2D6 CYP2E1 ALOX5 PROLINE CATABOLISM%REACTOME%R-HSA-70688.2 Proline catabolism PRODH2 PRODH ALDH4A1 RHO GTPASE CYCLE%REACTOME DATABASE ID RELEASE 72%194840 Rho GTPase cycle ECT2 ARHGEF33 ARHGEF35 ARHGEF37 ARHGEF39 ARHGEF38 NET1 RASGRF2 ARHGEF10L OCRL AKAP13 MCF2L ARHGEF11 ARHGEF10 ARHGEF12 PLEKHG2 ARHGEF15 ARHGEF17 PLEKHG5 ARHGEF16 ARHGEF19 ARHGEF9 ARHGEF3 ARHGEF4 ARHGEF1 ARHGEF2 SOS2 ARHGEF5 FGD1 FGD2 FGD3 GNA13 FGD4 MCF2 FAM13B FAM13A ARHGDIG ARHGAP39 ARHGAP36 SYDE2 ARHGAP44 SYDE1 ARHGAP42 OPHN1 ARHGAP40 ARHGDIB RALBP1 STARD8 HMHA1 BCR DEPDC1B ARHGAP19 ARHGAP18 ARHGAP17 ARHGAP15 RHOBTB1 RHOBTB2 ARHGAP12 ARHGAP22 ARHGAP21 RHOT2 ARHGAP20 RHOT1 RACGAP1 SRGAP3 SRGAP1 STARD13 ARHGAP29 ARHGAP28 ARHGAP27 ARHGAP26 ARHGAP25 ARHGAP24 ARHGAP23 ARHGAP33 ARHGAP32 ARHGAP31 ARHGAP30 RAC1 TIAM2 ARHGAP11A ARHGAP9 VAV3 ARHGAP11B ARHGAP8 GDI1 GDI2 ARHGAP1 ARHGAP5 VAV1 ARHGAP6 VAV2 ARHGAP4 TAGAP RAC2 RAC3 ARHGEF7 RHOG ARAP2 ARAP3 RHOH RHOF RHOC GMIP RHOD RHOB ARHGAP10 MYO9B DEPDC7 PIK3R2 RHOJ RHOU CDC42 TIAM1 RHOV RHOQ CHN2 CHN1 MYO9A DLC1 TRIP10 A2M ARHGDIA ARHGAP35 ARAP1 INPP5B SOS1 TRIO ARHGEF18 ITSN1 RHOA PREX1 ARHGEF40 OBSCN NGEF ARHGEF26 ARHGEF6 KALRN ABR RMTS METHYLATE HISTONE ARGININES%REACTOME%R-HSA-3214858.2 RMTs methylate histone arginines SMARCA4 PRMT5 HIST2H2AB PRMT1 RBBP7 JAK2 PRMT6 PBRM1 PRMT7 ACTL6B PRMT3 HIST1H2AE HIST1H2AD SMARCD3 HIST1H2AC HIST1H2AB HIST1H2AJ HIST2H3A HIST2H3D HIST3H2A HIST2H3C H2AFB1 HIST1H3J CCND1 HIST1H3A HIST1H3F HIST1H2AG HIST1H3G ARID2 ACTL6A HIST1H3H HIST1H2AA HIST1H3I HIST1H2AM HIST1H3B HIST1H2AL HIST1H3C HIST1H3D HIST1H2AI HIST1H3E CARM1 HIST1H2AH HIST1H4K HIST1H2AK HIST1H4L RPS2 HIST1H4A HIST1H4B HIST1H4H HIST1H4I HIST1H4J HIST1H4C HIST1H4D HIST1H4E HIST1H4F HIST2H2AA3 HIST2H2AA4 HIST2H2AC COPRS CDK4 H2AFJ H2AFZ DNMT3A H2AFX WDR5 H2AFV SMARCB1 ARID1A ARID1B HIST4H4 SMARCD1 SMARCD2 SMARCC1 SMARCC2 SMARCE1 WDR77 HIST2H4A HIST2H4B SMARCA2 PLC BETA MEDIATED EVENTS%REACTOME%R-HSA-112043.1 PLC beta mediated events CAMK2D CAMK2A PRKAR2B PRKAR2A PRKCD PRKCA CAMK2G PRKCG ITPR1 NBEA ITPR2 ITPR3 CAMK4 ADCY4 ADCY3 PRKACG ADCY2 PRKACA ADCY1 PRKACB ADCY8 ADCY7 ADCY6 ADCY5 PDE1C ADRBK1 GNAT2 GNAT3 GNAT1 PLCB3 PLCB4 PLCB1 PLCB2 KPNA2 CREB1 GNAZ MAPK1 GNAO1 CAMKK1 CAMKK2 PDE1B PDE1A PLA2G4A GNAI3 GNAI1 GNAI2 AHCYL1 PRKX ADCY9 PRKAR1B PRKAR1A CAMK2B INSULIN RECEPTOR SIGNALLING CASCADE%REACTOME%R-HSA-74751.3 Insulin receptor signalling cascade PDPK1 FRS2 PTPN11 FGF16 TRIB3 FGF7 FGF18 TLR9 INS SHC1 GAB1 PIK3R1 PIK3R2 FGF6 PIK3CA FGF9 SOS1 FGF20 FGF1 FGF2 FGF23 FGF3 FGF22 PIK3C3 FGF10 FGF4 HRAS PIK3R4 KLB IRS1 FLT3 NRAS PDE3B IRS2 GRB10 THEM4 INSR FLT3LG GAB2 FGF19 PIK3CB FGFR4 AKT2 MAPK1 MAPK3 S37 MUTANTS OF BETA-CATENIN AREN'T PHOSPHORYLATED%REACTOME DATABASE ID RELEASE 72%5358749 S37 mutants of beta-catenin aren't phosphorylated CSNK1A1 PPP2CA PPP2CB PPP2R5B PPP2R5A PPP2R5D CTNNB1 GSK3B PPP2R5C PPP2R1B PPP2R1A AMER1 AXIN1 APC PPP2R5E ADENYLATE CYCLASE INHIBITORY PATHWAY%REACTOME DATABASE ID RELEASE 72%170670 Adenylate cyclase inhibitory pathway GNAI3 GNAT3 GNAI1 GNAI2 GNAL ADCY4 ADCY3 ADCY2 ADCY1 ADCY9 ADCY8 ADCY7 ADCY6 ADCY5 CATION-COUPLED CHLORIDE COTRANSPORTERS%REACTOME%R-HSA-426117.1 Cation-coupled Chloride cotransporters SLC12A6 SLC12A7 SLC12A2 SLC12A3 SLC12A4 SLC12A5 SLC12A1 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE%REACTOME%R-HSA-1660516.7 Synthesis of PIPs at the early endosome membrane PI4K2B MTMR2 PIK3R4 PIK3C2A INPP5F FIG4 MTMR4 PI4K2A VAC14 MTM1 MTMR10 MTMR12 PIKFYVE INPP4A PIK3C3 INPP4B BIOTIN TRANSPORT AND METABOLISM%REACTOME DATABASE ID RELEASE 72%196780 Biotin transport and metabolism PCCA ACACA PCCB HLCS MCCC2 PDZD11 SLC5A6 MCCC1 PC BTD ACACB TRNA PROCESSING IN THE MITOCHONDRION%REACTOME DATABASE ID RELEASE 72%6785470 tRNA processing in the mitochondrion HSD17B10 TRMT10C ELAC2 TRNT1 KIAA0391 BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS%REACTOME%R-HSA-390247.3 Beta-oxidation of very long chain fatty acids ACOT8 ACOT6 ACOT4 ACAA1 EHHADH ABCD1 DECR2 HSD17B4 SYNTHESIS OF PI%REACTOME%R-HSA-1483226.3 Synthesis of PI CDS1 CDIPT PITPNM1 PITPNM3 PITPNM2 REGULATED NECROSIS%REACTOME%R-HSA-5218859.1 Regulated Necrosis RIPK3 BIRC2 MLKL BIRC3 XIAP CASP8 TRADD TNFSF10 FAS TNFRSF10B FASLG RIPK1 TNFRSF10A TRAF2 FADD TOXICITY OF BOTULINUM TOXIN TYPE A (BONT A)%REACTOME%R-HSA-5250968.1 Toxicity of botulinum toxin type A (BoNT A) SV2B SV2A SNAP25 SV2C CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS%REACTOME DATABASE ID RELEASE 72%2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants CUL1 NCSTN ADAM10 APH1B TBL1X CCNC UBA52 PSENEN TBL1XR1 EP300 ADAM17 UBB UBC RPS27A MYC NOTCH1 MAML2 MAML1 RBPJ HES1 SNW1 MAML3 MAMLD1 NCOR2 CREBBP HDAC11 HEY1 NCOR1 HDAC3 HEY2 HDAC4 HDAC5 DLL1 HDAC10 HDAC9 KAT2B HDAC6 KAT2A HDAC7 DLL4 NEURL1B HES5 JAG2 JAG1 MIB2 MIB1 HDAC8 HEYL NEURL1 HDAC2 SKP1 HDAC1 RBX1 PSEN2 PSEN1 APH1A CDK8 DEFECTIVE ABCC9 CAUSES DILATED CARDIOMYOPATHY 10, FAMILIAL ATRIAL FIBRILLATION 12 AND HYPERTRICHOTIC OSTEOCHONDRODYSPLASIA%REACTOME%R-HSA-5678420.1 Defective ABCC9 causes dilated cardiomyopathy 10, familial atrial fibrillation 12 and hypertrichotic osteochondrodysplasia ABCC9 KCNJ11 SYNTHESIS OF WYBUTOSINE AT G37 OF TRNA(PHE)%REACTOME DATABASE ID RELEASE 72%6782861 Synthesis of wybutosine at G37 of tRNA(Phe) TYW5 TRMT5 TYW3 TYW1 TRMT12 LCMT2 DEFECTIVE NEU1 CAUSES SIALIDOSIS%REACTOME%R-HSA-4341670.1 Defective NEU1 causes sialidosis GLB1 NEU1 CTSA MECP2 REGULATES TRANSCRIPTION OF NEURONAL LIGANDS%REACTOME DATABASE ID RELEASE 72%9022702 MECP2 regulates transcription of neuronal ligands CREB1 DLL1 HDAC1 CRH BDNF SIN3A SST PROCESSING OF INTRONLESS PRE-MRNAS%REACTOME%R-HSA-77595.2 Processing of Intronless Pre-mRNAs CSTF1 SYMPK CPSF4 CPSF7 CPSF1 CSTF3 CPSF3 CSTF2 CPSF2 CSTF2T WDR33 NUDT21 FIP1L1 NCBP1 PABPN1 NCBP2 CLP1 PCF11 PAPOLA TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 72%168179 Toll Like Receptor TLR1:TLR2 Cascade CUL1 MAP2K1 MAPKAPK3 UBA52 MAPK8 PPP2R1B ATF1 PPP2R1A APP ATF2 NFKBIA IKBKG ELK1 RELA RPS6KA3 RPS6KA5 RPS6KA2 RPS6KA1 DUSP4 PPP2R5D MEF2A MEF2C IRAK3 DUSP3 TIRAP TLR1 FOS SIGIRR VRK3 TLR6 UBB TLR2 DUSP6 DUSP7 UBC CREB1 MAPKAPK2 RPS27A MAPK7 MAPK1 MAPK3 PPP2CA HMGB1 PPP2CB IKBKB NKIRAS1 NKIRAS2 MAPK14 MAP3K8 MAP2K3 CHUK MAPK11 MAP2K4 RIPK2 IRAK4 PELI1 UBE2N UBE2V1 PELI3 PELI2 NOD1 NFKB1 NOD2 NFKB2 AGER MAPK9 IRAK1 MAP2K6 S100A12 MAP2K7 MAP3K1 CD36 S100B MAPK10 TNIP2 JUN SAA1 MYD88 NFKBIB FBXW11 SOCS1 BTRC ECSIT SKP1 BTK IRAK2 TRAF6 TAB3 LY96 TAB2 TAB1 MAP3K7 CD14 TLR4 CA-DEPENDENT EVENTS%REACTOME DATABASE ID RELEASE 72%111996 Ca-dependent events CAMK2D CAMK2A PRKAR2B PRKAR2A PRKCD PRKCA CAMK2G PRKCG NBEA CAMK4 CAMKK1 ADCY4 CAMKK2 ADCY3 PRKACG ADCY2 ADCY1 PRKACA ADCY8 PRKACB ADCY7 ADCY6 PDE1B ADCY5 PDE1C PDE1A ADRBK1 PLA2G4A PRKX KPNA2 CREB1 ADCY9 MAPK1 PRKAR1B PRKAR1A CAMK2B CALCITONIN-LIKE LIGAND RECEPTORS%REACTOME%R-HSA-419812.1 Calcitonin-like ligand receptors RAMP1 CALCA CALCRL CALCB RAMP2 RAMP3 ADM2 CALCR ADM IAPP SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1%REACTOME%R-HSA-1839122.1 Signaling by activated point mutants of FGFR1 FGF6 FGF9 FGF20 FGF1 FGF2 FGF23 FGF4 FGFR1 AUF1 (HNRNP D0) BINDS AND DESTABILIZES MRNA%REACTOME%R-HSA-450408.3 AUF1 (hnRNP D0) binds and destabilizes mRNA PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 PABPC1 UBA52 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 UBB PSMB3 UBC PSMB1 PSMF1 RPS27A HSPA8 SHFM1 PSMB8 PSMB9 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 EIF4G1 HSPB1 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME%R-HSA-109606.3 Intrinsic Pathway for Apoptosis AKT1 BCL2L11 YWHAG YWHAZ YWHAH APAF1 CASP7 CASP3 TFDP1 MAPK8 TFDP2 BID C1QBP CDKN2A E2F1 XIAP DYNLL2 BAX AVEN PPP3CC MAPK1 TP63 DIABLO UACA MAPK3 PPP3R1 APIP BMF BAK1 CARD8 GZMB NMT1 BCL2L1 BAD BCL2 CASP9 TP53 CASP8 PMAIP1 TP53BP2 SFN TP73 DYNLL1 CYCS YWHAB YWHAE AKT2 STAT3 AKT3 PPP1R13B BBC3 YWHAQ SIGNALLING TO ERK5%REACTOME DATABASE ID RELEASE 72%198765 Signalling to ERK5 MAP2K5 MAPK7 LATE PHASE OF HIV LIFE CYCLE%REACTOME%R-HSA-162599.2 Late Phase of HIV Life Cycle GTF2B GTF2A1 TCEB3C GTF2A2 RNMT GTF2E1 TCEB3B GTF2E2 POLR2E RNGTT POLR2F POLR2H NUP107 NUP188 POLR2K POLR2L GTF2H1 GTF2H2 GTF2H3 GTF2H4 NUP62 GTF2H5 NDC1 ERCC3 NUP214 ERCC2 SEC13 TAF9 TAF1L NUP133 NUP210 NUP93 NUP50 TAF15 NUP54 TAF12 TAF13 CCNK TAF10 TAF11 SSRP1 POM121 NUP205 CTDP1 TAF7 NCBP1 TAF6 NCBP2 TAF5 SUPT4H1 AAAS TAF4 NUP160 SUPT5H TAF3 GTF2F1 TAF2 GTF2F2 NUP85 POLR2A TPR POLR2B TAF1 NMT1 POLR2C NUP88 POLR2D NUP43 POLR2G NELFB NELFA NELFCD RAE1 POLR2I POLR2J RANBP2 PPIA CHMP2A NELFE NMT2 NUP155 PDCD6IP RANBP1 NUP153 NUP35 NUPL2 NUP37 ELL XPO1 FURIN TAF7L TSG101 VPS4B VPS4A MVB12B MVB12A VTA1 VPS37C VPS37D VPS37A TCEB3CL2 CCNH VPS37B CHMP2B CHMP4C UBAP1 CHMP4B UBA52 TCEB3 CHMP3 CHMP4A TCEB2 CHMP6 TCEB1 TCEB3CL TAF9B CHMP7 VPS28 CHMP5 TCEA1 UBB UBC CCNT2 CCNT1 RPS27A SUPT16H CDK7 MNAT1 RANGAP1 RCC1 AK6 NEDD4L RAN TBP CDK9 TAF4B SIGNALING BY EGFRVIII IN CANCER%REACTOME%R-HSA-5637812.1 Signaling by EGFRvIII in Cancer HRAS NRAS EGF SHC1 GAB1 PIK3R1 CBL EGFR PIK3CA PLCG1 SOS1 HSP90AA1 CDC37 GLYCOPROTEIN HORMONES%REACTOME DATABASE ID RELEASE 72%209822 Glycoprotein hormones CGA INHBC INHBE FSHB LHB INHA TSHB INHBB INHBA TOLL LIKE RECEPTOR 10 (TLR10) CASCADE%REACTOME%R-HSA-168142.1 Toll Like Receptor 10 (TLR10) Cascade CUL1 MAP2K1 MAPKAPK3 UBA52 MAPK8 PPP2R1B ATF1 PPP2R1A APP ATF2 NFKBIA IKBKG ELK1 RELA RPS6KA3 RPS6KA5 RPS6KA2 RPS6KA1 DUSP4 PPP2R5D MEF2A MEF2C DUSP3 FOS VRK3 UBB DUSP6 DUSP7 UBC CREB1 MAPKAPK2 RPS27A MAPK7 MAPK1 MAPK3 PPP2CA HMGB1 PPP2CB IKBKB NKIRAS1 NKIRAS2 MAPK14 MAP3K8 MAP2K3 CHUK MAPK11 MAP2K4 RIPK2 IRAK4 PELI1 UBE2N UBE2V1 PELI3 PELI2 NOD1 NFKB1 TLR10 NOD2 NFKB2 TLR5 AGER MAPK9 IRAK1 MAP2K6 S100A12 MAP2K7 MAP3K1 S100B MAPK10 TNIP2 JUN SAA1 MYD88 NFKBIB FBXW11 BTRC ECSIT SKP1 IRAK2 TRAF6 TAB3 TAB2 TAB1 MAP3K7 DEFECTIVE ABCA3 CAUSES PULMONARY SURFACTANT METABOLISM DYSFUNCTION 3 (SMDP3)%REACTOME%R-HSA-5688399.1 Defective ABCA3 causes pulmonary surfactant metabolism dysfunction 3 (SMDP3) ABCA3 TAT-MEDIATED HIV ELONGATION ARREST AND RECOVERY%REACTOME%R-HSA-167243.3 Tat-mediated HIV elongation arrest and recovery GTF2F1 GTF2F2 POLR2A POLR2B TCEB3C POLR2C POLR2D TCEB3B POLR2G POLR2E NELFB POLR2F NELFA NELFCD POLR2H POLR2I POLR2J NELFE POLR2K TCEB3CL2 POLR2L TCEB3 TCEB2 TCEB1 TCEB3CL CDK9 TCEA1 ELL CCNT1 SSRP1 CTDP1 SUPT16H SUPT4H1 SUPT5H PROGRAMMED CELL DEATH%REACTOME%R-HSA-5357801.2 Programmed Cell Death BCL2L11 CDH1 YWHAG YWHAH APAF1 KPNA1 CASP3 TFDP1 MAPK8 TFDP2 E2F1 BIRC2 BIRC3 XIAP DYNLL2 BAX AVEN PPP3CC TP63 DIABLO UACA PPP3R1 BMF HMGB1 BAK1 CARD8 GZMB NMT1 LMNB1 BCL2L1 BCL2 BAD CASP9 DBNL TP53 TP53BP2 SFN UNC5A DAPK1 UNC5B DAPK2 DAPK3 OMA1 OPA1 APPL1 TP73 DYNLL1 DCC YWHAB AKT2 PSMD8 AKT3 PSMD9 PSMD6 TICAM2 LY96 PSMD7 TICAM1 PSMD4 CD14 PSMD5 BBC3 TLR4 PSMD2 PSMD3 AKT1 PSMD1 PRKCD YWHAZ PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 ROCK1 PSMA2 PSME3 PSME4 PSME1 PSME2 HMGB2 CASP7 ARHGAP10 FNTA UBA52 HIST1H1D PSMD10 HIST1H1E DNM1L PSMB11 PSMD12 SPTAN1 HIST1H1A PSMD11 HIST1H1B BID PSMD14 HIST1H1C DSP PSMD13 DFFB C1QBP DFFA CDKN2A APC GAS2 PSMA7 DSG1 PSMB10 PAK2 PKP1 PSMA8 PRKCQ DSG2 MAPT PSMB6 DSG3 PLEC PSMB7 PTK2 SATB1 PSMB4 BCAP31 GSN PSMB5 TJP1 OCLN PSMB2 UBB H1F0 STK24 PSMB3 CTNNB1 STK26 ACIN1 UBC VIM PSMB1 TJP2 PSMF1 BMX RPS27A KPNB1 SHFM1 PSMB8 PSMB9 MAPK1 PSMC5 PSMC6 MAPK3 PSMC3 PSMC4 APIP PSMC1 PSMC2 MLKL CASP8 TRADD TNFSF10 PMAIP1 FAS TNFRSF10B FASLG RIPK1 TNFRSF10A TRAF2 FADD ADD1 CLSPN RIPK3 CYCS YWHAE STAT3 PPP1R13B MAGED1 YWHAQ CASP6 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT%REACTOME DATABASE ID RELEASE 72%201681 TCF dependent signaling in response to WNT MEN1 PPP2R5C CSNK2A1 CSNK1A1 CSNK2A2 CTBP1 CSNK2B XIAP RNF43 WNT3A FZD4 FZD6 LRP5 FZD8 LRP6 CUL3 CSNK1E HIST1H2AE DVL1 HIST1H2AD HIST3H2BB DVL3 HIST1H2AC HIST1H2AB HIST1H2AJ HIST2H3A SOX2 HIST1H2BF SOX3 HIST1H2BE FRAT1 HIST1H2BH FRAT2 HIST1H2BG SOX17 HIST2H3D SOX9 HIST1H2BB SOX6 HIST1H2BA SOX7 HIST2H3C SOX4 HIST1H2BD SOX13 HIST1H2BC DKK1 H2AFB1 DKK2 DKK4 HIST1H3J SFRP1 SFRP2 HIST1H3A HECW1 HIST1H3F HIST1H3G CCDC88C HIST1H3H RSPO2 HIST1H3I RSPO3 RSPO1 HIST1H3B RSPO4 HIST1H3C KREMEN1 HIST1H3D KREMEN2 HIST1H3E WNT9A H3F3B WNT8A MYC HIST1H4K WNT8B WIF1 HIST1H4L LEO1 H3F3A LGR6 LGR5 LGR4 H2BFS HIST1H4A TLE4 TLE3 HIST1H4B TLE2 HIST1H4H TLE1 HIST1H4I CTNNBIP1 HIST1H4J PYGO1 HIST1H4C PYGO2 TCF7 HIST1H4D KLHL12 HIST1H4E WNT1 WNT3 WNT4 HIST1H4F BCL9L HIST2H2AA3 BCL9 GSK3B CHD8 HIST2H2AA4 USP34 RUVBL1 CBY1 CDC73 SOST HIST2H2AC DACT1 AXIN2 LEF1 ZNRF3 H2AFJ SRY TCF7L1 H2AFZ H2AFX H2AFV RUNX3 HIST2H2BE TRRAP HIST4H4 HIST1H2BN HIST1H2BM HIST1H2BO HIST1H2BJ HDAC1 HIST1H2BI HIST1H2BL HIST1H2BK HIST2H4A HIST2H4B SMARCA4 ASH2L CSNK1G2 PPP2R1B PPP2R1A TERT PPP2R5D PIP5K1B HIST3H3 TNKS TNKS2 RNF146 KAT5 PPP2CA PPP2CB KMT2D TCF7L2 CREBBP FZD2 FZD5 WNT5A RBBP5 AKT2 PSMD8 PSMD9 PSMD6 XPO1 PSMD7 PSMD4 AMER1 PSMD5 AXIN1 PSMD2 PPP2R5E PSMD3 AKT1 PSMD1 PPP2R5B PPP2R5A YWHAZ PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 UBA52 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 APC PSMA7 PSMB10 PSMA8 DVL2 FZD1 PSMB6 EP300 CAV1 PSMB7 SMURF2 PSMB4 PSMB5 PSMB2 UBB PSMB3 CTNNB1 UBC PSMB1 PSMF1 RPS27A SHFM1 PSMB8 PSMB9 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 BTRC RBX1 USP8 TFAP2A ACTS AS A TRANSCRIPTIONAL REPRESSOR DURING RETINOIC ACID INDUCED CELL DIFFERENTIATION%REACTOME%R-HSA-8869496.2 TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation TFAP2A MYBL2 NOP2 HSPD1 NPM1 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS%REACTOME%R-HSA-141405.4 Inhibition of the proteolytic activity of APC C required for the onset of anaphase by mitotic spindle checkpoint components BUB3 ANAPC15 ANAPC16 ANAPC7 UBE2C UBE2E1 UBE2D1 ANAPC10 ANAPC11 CDC23 CDC26 CDC27 CDC16 ANAPC4 BUB1B ANAPC5 ANAPC1 MAD2L1 ANAPC2 CDC20 EUKARYOTIC TRANSLATION TERMINATION%REACTOME%R-HSA-72764.4 Eukaryotic Translation Termination N6AMT1 RPL26 RPL29 RPL10L RPS4X RPL10A RPL28 RPS3A RPL7A RPL23A FAU RPL41 RPS27L RPL3L UBA52 RPL37A RPS26 RPS25 RPS28 GSPT2 GSPT1 RPS27 RPL36A RPS29 RPL35A RPS20 RPS21 RPS24 RPS23 ETF1 RPL22L1 RPS4Y2 RPL10 RPS4Y1 RPS27A RPL12 RPL13A RPL11 RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL27A RPL26L1 RPL4 RPL39L RPL5 RPL30 RPL3 RPL32 RPL31 RPS9 APEH RPS7 RPL34 RPS8 RPL8 RPS5 RPL9 RPS6 RPL6 RPL7 RPSA RPL36 RPS15 RPS14 RPL35 RPS17 RPL38 RPS16 RPL37 RPL39 RPS19 RPS15A RPL18A RPL36AL RPS18 RPLP1 RPL21 RPL23 RPS11 RPL22 RPLP0 RPS10 RPS13 TRMT112 RPS12 RPLP2 RPL24 RPL27 ANTIMICROBIAL ACTION AND ANTIMICROBIAL RESISTANCE IN MTB%REACTOME%R-HSA-9639775.1 Antimicrobial action and antimicrobial resistance in Mtb TNFR2 NON-CANONICAL NF-KB PATHWAY%REACTOME DATABASE ID RELEASE 72%5668541 TNFR2 non-canonical NF-kB pathway CUL1 TNFRSF6B TNFSF11 TNFRSF8 TNFRSF4 EDAR TNFRSF11B TNFRSF11A TNFRSF17 TNFRSF14 TNFSF18 TNFSF14 TNFSF15 TNFSF12 TNFRSF9 TNFSF4 UBA3 TNFSF9 CD27 TNFSF8 MAP3K14 UBE2M EDA TNFRSF13B TNFRSF13C EDA2R TNFSF13B EDARADD TNFRSF12A TNFRSF18 TNFRSF1B TNFRSF1A LTA TNFRSF25 LTB RELB CD70 CD40LG LTBR BIRC2 BIRC3 TRAF3 CHUK NFKB2 FBXW11 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 UBA52 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 UBB PSMB3 UBC PSMB1 PSMF1 RPS27A SHFM1 TNFSF13 PSMB8 PSMB9 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 FASLG TRAF2 TNF BTRC SKP1 SUMOYLATION OF TRANSCRIPTION FACTORS%REACTOME%R-HSA-3232118.7 SUMOylation of transcription factors SUMO2 TFAP2C UBE2I TP53 MDM2 TFAP2B PIAS4 MITF FOXL2 HIC1 SP3 PIAS3 TP53BP1 PIAS1 CDKN2A SUMO1 MTA1 SUMO3 ASSEMBLY OF THE HIV VIRION%REACTOME%R-HSA-175474.1 Assembly Of The HIV Virion TSG101 MVB12B MVB12A VPS37C VPS37D UBB PPIA VPS37A NMT2 VPS37B UBC UBAP1 RPS27A UBA52 VPS28 FURIN CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS%REACTOME DATABASE ID RELEASE 72%2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants CUL1 NCSTN ADAM10 APH1B TBL1X CCNC UBA52 PSENEN TBL1XR1 EP300 ADAM17 UBB UBC RPS27A MYC NOTCH1 MAML2 MAML1 RBPJ HES1 SNW1 MAML3 MAMLD1 NCOR2 CREBBP HDAC11 HEY1 NCOR1 HDAC3 HEY2 HDAC4 HDAC5 DLL1 HDAC10 HDAC9 KAT2B HDAC6 KAT2A HDAC7 DLL4 NEURL1B HES5 JAG2 JAG1 MIB2 MIB1 HDAC8 HEYL NEURL1 HDAC2 SKP1 HDAC1 RBX1 PSEN2 PSEN1 APH1A CDK8 CARNITINE METABOLISM%REACTOME%R-HSA-200425.5 Carnitine metabolism CPT2 THRSP MID1IP1 SLC22A5 RXRA PRKAG2 SLC25A20 CPT1A CPT1B PRKAA2 PRKAB2 PPARD REDUCTION OF CYTOSOLIC CA++ LEVELS%REACTOME%R-HSA-418359.1 Reduction of cytosolic Ca++ levels ATP2A1 ATP2B4 ATP2B3 SRI ATP2B2 ATP2B1 SLC8A3 ATP2A3 SLC8A1 ATP2A2 SLC8A2 FGFR2B LIGAND BINDING AND ACTIVATION%REACTOME%R-HSA-190377.2 FGFR2b ligand binding and activation FGFBP1 FGFBP2 FGFBP3 FGF1 FGF7 FGF2 FGF3 FGF22 FGF10 ERBB2 REGULATES CELL MOTILITY%REACTOME%R-HSA-6785631.3 ERBB2 Regulates Cell Motility NRG1 NRG2 BTC NRG3 NRG4 RHOA HBEGF EREG EGF EGFR MEMO1 ERBB2 DIAPH1 RUNX3 REGULATES BCL2L11 (BIM) TRANSCRIPTION%REACTOME DATABASE ID RELEASE 72%8952158 RUNX3 regulates BCL2L11 (BIM) transcription BCL2L11 SMAD3 SMAD4 FOXO3 RUNX3 RRNA PROCESSING IN THE MITOCHONDRION%REACTOME%R-HSA-8868766.2 rRNA processing in the mitochondrion NSUN4 RNMTL1 HSD17B10 MTERF4 FTSJ2 TRMT10C MRM1 ELAC2 KIAA0391 TFB1M ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1%REACTOME DATABASE ID RELEASE 72%418592 ADP signalling through P2Y purinoceptor 1 GNG11 GNG13 PLA2G4A MAPK14 GNB2 GNB1 GNB4 P2RY1 GNB3 GNG3 GNG2 GNG5 GNB5 GNG4 GNG7 GNAQ GNG8 GNGT1 GNGT2 GNA14 GNA15 GNG10 GNA11 GNG12 DEFECTIVE SLC34A3 CAUSES HEREDITARY HYPOPHOSPHATEMIC RICKETS WITH HYPERCALCIURIA (HHRH)%REACTOME DATABASE ID RELEASE 72%5619097 Defective SLC34A3 causes Hereditary hypophosphatemic rickets with hypercalciuria (HHRH) SLC34A3 SIGNALING BY FGFR3 POINT MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 72%8853338 Signaling by FGFR3 point mutants in cancer HRAS FRS2 FGF16 FGFR3 FGF18 NRAS GAB1 PIK3R1 PIK3CA FGF9 PLCG1 SOS1 FGF20 FGF1 FGF2 FGF23 FGF4 RUNX1 REGULATES ESTROGEN RECEPTOR MEDIATED TRANSCRIPTION%REACTOME DATABASE ID RELEASE 72%8931987 RUNX1 regulates estrogen receptor mediated transcription GPAM CBFB AXIN1 ESR1 KCTD6 RUNX1 DISEASES OF CELLULAR RESPONSE TO STRESS%REACTOME DATABASE ID RELEASE 72%9675132 Diseases of cellular response to stress CDK6 CDK4 CDKN2A HSF1 ACTIVATION%REACTOME%R-HSA-3371511.1 HSF1 activation HSBP1 RPA1 HSF1 RPA2 YWHAE RPA3 VCP HDAC6 HSP90AB1 HSP90AA1 EEF1A1 PTGES3 PRE-NOTCH PROCESSING IN GOLGI%REACTOME DATABASE ID RELEASE 72%1912420 Pre-NOTCH Processing in Golgi MFNG ST3GAL4 TMED2 ST3GAL6 RAB6A ST3GAL3 B4GALT1 ATP2A3 ATP2A2 ATP2A1 NOTCH2 SEL1L NOTCH3 FURIN NOTCH4 RFNG NOTCH1 LFNG PECAM1 INTERACTIONS%REACTOME%R-HSA-210990.1 PECAM1 interactions PTPN6 LYN YES1 PLCG1 PTPN11 ITGAV FYN INPP5D LCK ITGB3 DISEASES OF BASE EXCISION REPAIR%REACTOME%R-HSA-9605308.3 Diseases of Base Excision Repair NTHL1 OGG1 NEIL3 NEIL1 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN%REACTOME%R-HSA-174154.2 APC C:Cdc20 mediated degradation of Securin PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 UBA52 CDC20 PSMD10 PTTG1 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 ANAPC15 ANAPC16 PSMB6 ANAPC7 PSMB7 UBE2C UBE2E1 PSMB4 UBE2D1 ANAPC10 PSMB5 ANAPC11 PSMB2 UBB CDC23 PSMB3 CDC26 CDC27 UBC CDC16 PSMB1 ANAPC4 PSMF1 ANAPC5 ANAPC1 RPS27A ANAPC2 SHFM1 PSMB8 PSMB9 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 ACTIVATION OF AMPK DOWNSTREAM OF NMDARS%REACTOME DATABASE ID RELEASE 72%9619483 Activation of AMPK downstream of NMDARs PRKAB1 PRKAG1 CAMKK2 PRKAG2 PRKAA1 PRKAG3 PRKAA2 PRKAB2 ESTROGEN-DEPENDENT GENE EXPRESSION%REACTOME DATABASE ID RELEASE 72%9018519 Estrogen-dependent gene expression GTF2A1 GTF2A2 POLR2E POLR2F POLR2H POLR2K POLR2L SMC3 KDM4B DDX5 RAD21 KDM1A STAG1 NRIP1 STAG2 CTSD CCND1 SMC1A TNRC6C KAT5 CARM1 GTF2F1 GTF2F2 TNRC6A POLR2A TNRC6B POLR2B POLR2C POLR2D POLR2G BCL2 POLR2I POLR2J ESR1 KCTD6 NCOA1 JUN NCOA2 CREBBP NCOA3 MOV10 AGO3 AGO4 AGO1 AGO2 TGFA FOXA1 MYB PGR FKBP4 GATA3 POU2F1 GREB1 CXCL12 AXIN1 CITED1 CHD1 NR5A2 TFF1 KANK1 CXXC5 GPAM USF2 USF1 ZNF217 EBAG9 PRMT1 CBFB RUNX1 HIST1H2AE HIST1H2AD HIST3H2BB ATF2 HIST1H2AC HIST1H2AB HIST1H2AJ HIST2H3A HIST1H2BF HIST1H2BE HIST1H2BH EP300 HIST1H2BG HIST2H3D HIST1H2BB HIST1H2BA HIST2H3C HIST1H2BD HIST1H2BC H2AFB1 FOS HIST1H3J HIST1H3A HIST1H3F HIST1H3G KPNA2 HIST1H3H CCNT1 HIST1H3I HIST1H3B HIST1H3C SP1 HIST1H3D HIST1H3E H3F3B MYC HIST1H4K HIST1H4L H3F3A H2BFS HIST1H4A TLE3 JUND HIST1H4B HIST1H4H HIST1H4I HIST1H4J HIST1H4C HIST1H4D HSP90AB1 HIST1H4E HIST1H4F PTGES3 FOSB YY1 HIST2H2AA3 HIST2H2AA4 HIST2H2AC H2AFJ HSP90AA1 TBP H2AFZ CDK9 H2AFX H2AFV HIST2H2BE KAT2B HIST4H4 MED1 HIST1H2BN HIST1H2BM HIST1H2BO HIST1H2BJ HDAC1 HIST1H2BI HIST1H2BL HIST1H2BK HIST2H4A HIST2H4B PROCESSIVE SYNTHESIS ON THE LAGGING STRAND%REACTOME DATABASE ID RELEASE 72%69183 Processive synthesis on the lagging strand LIG1 RPA1 RPA2 POLD3 POLD4 RPA3 POLD1 POLA1 POLD2 POLA2 DNA2 PRIM2 PRIM1 FEN1 PCNA ACTIVATION OF THE TFAP2 (AP-2) FAMILY OF TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 72%8866907 Activation of the TFAP2 (AP-2) family of transcription factors TFAP2A TFAP2C EP300 CITED2 WWOX TFAP2D YEATS4 TFAP2B CITED1 TFAP2E CREBBP CITED4 HIV LIFE CYCLE%REACTOME%R-HSA-162587.2 HIV Life Cycle LIG1 GTF2B GTF2A1 TCEB3C GTF2A2 RNMT GTF2E1 TCEB3B GTF2E2 POLR2E RNGTT POLR2F POLR2H NUP107 NUP188 POLR2K PSIP1 POLR2L BANF1 KPNA1 HMGA1 GTF2H1 GTF2H2 GTF2H3 GTF2H4 NUP62 GTF2H5 NDC1 ERCC3 NUP214 ERCC2 SEC13 TAF9 TAF1L CD4 NUP133 NUP210 NUP93 NUP50 TAF15 NUP54 TAF12 TAF13 CCNK TAF10 TAF11 SSRP1 POM121 NUP205 CTDP1 TAF7 NCBP1 TAF6 NCBP2 TAF5 SUPT4H1 AAAS TAF4 NUP160 SUPT5H TAF3 GTF2F1 TAF2 GTF2F2 NUP85 POLR2A TPR POLR2B TAF1 NMT1 POLR2C NUP88 POLR2D NUP43 POLR2G NELFB NELFA NELFCD RAE1 POLR2I POLR2J RANBP2 PPIA CHMP2A NELFE NMT2 NUP155 PDCD6IP RANBP1 NUP153 NUP35 NUPL2 NUP37 ELL XPO1 FURIN TAF7L TSG101 VPS4B VPS4A MVB12B MVB12A VTA1 VPS37C VPS37D VPS37A TCEB3CL2 CCNH VPS37B CHMP2B CHMP4C CCR5 CXCR4 UBAP1 CHMP4B UBA52 TCEB3 CHMP3 CHMP4A TCEB2 CHMP6 TCEB1 TCEB3CL TAF9B CHMP7 VPS28 XRCC6 XRCC4 CHMP5 XRCC5 TCEA1 UBB UBC CCNT2 CCNT1 RPS27A SUPT16H CDK7 MNAT1 RANGAP1 RCC1 AK6 NEDD4L RAN LIG4 TBP CDK9 TAF4B FEN1 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES%REACTOME%R-HSA-425393.2 Transport of inorganic cations anions and amino acids oligopeptides SLC25A18 SLC7A7 SLC7A8 SLC7A9 SLC24A2 SLC24A4 SLC24A3 SLC20A2 SLC43A2 SLC20A1 SLC43A1 SLC5A12 SLC3A1 SLC7A1 SLC7A3 SLC25A26 SLC25A29 SLC17A6 SLC17A1 SLC25A22 SLC26A2 CTNS SLC26A1 SLC8B1 SLC4A7 SLC4A8 SLC4A9 SLC24A5 SLC8A1 SLC8A2 SLC25A10 SLC5A8 SLC24A1 SLC32A1 SLC5A5 SLC17A7 SLC17A8 SLC7A5 SLC34A3 SLC34A2 SLC34A1 SLC17A5 SLC38A1 SLC1A1 SLC1A2 SLC1A3 SLC1A6 SRI SLC1A7 SLC38A2 SLC3A2 SLC8A3 SLC6A20 SLC6A12 SLC9A1 SLC12A2 SLC12A3 SLC12A4 SLC12A5 SLC12A1 SLC12A6 SLC12A7 AHCYL2 SLC4A1 SLC4A2 SLC4A3 SLC4A4 SLC4A5 SLC26A11 SLC6A19 SLC15A1 SLC6A18 SLC15A2 SLC6A15 SLC6A14 SLC36A4 SLC9A2 SLC9A3 SLC9A4 SLC9A5 SLC9A6 SLC9A7 SLC9A8 SLC9A9 SLC1A4 SLC1A5 SLC38A3 SLC15A3 SLC15A4 SLC38A5 SLC38A4 SLC4A10 SLC16A10 SLC6A6 SLC26A7 SLC26A9 SLC26A4 SLC26A3 SLC26A6 SLC7A11 SLC7A10 SLC36A1 SLC36A2 SLC7A6 CS DS DEGRADATION%REACTOME DATABASE ID RELEASE 72%2024101 CS DS degradation BCAN VCAN IDUA NCAN HEXB BGN HYAL1 HEXA CSPG5 HYAL3 CSPG4 DCN IDS ARSB CONSTITUTIVE SIGNALING BY AKT1 E17K IN CANCER%REACTOME%R-HSA-5674400.1 Constitutive Signaling by AKT1 E17K in Cancer PDPK1 AKT1 TSC2 GSK3A FOXO3 CHUK BAD CASP9 GSK3B MAPKAP1 RICTOR FOXO6 FOXO4 NR4A1 RPS6KB2 AKT1S1 MTOR PRR5 MDM2 CDKN1A CDKN1B CREB1 AKT2 AKT3 MLST8 FOXO1 VITAMIN B1 (THIAMIN) METABOLISM%REACTOME DATABASE ID RELEASE 72%196819 Vitamin B1 (thiamin) metabolism TPK1 THTPA SLC19A3 SLC25A19 SLC19A2 RNA POLYMERASE III CHAIN ELONGATION%REACTOME%R-HSA-73780.2 RNA Polymerase III Chain Elongation CRCP POLR2E POLR2F POLR2H POLR1C POLR2K POLR2L POLR3GL POLR3A POLR3B POLR3C POLR3D POLR3E POLR3F POLR3G POLR3H POLR3K SMOOTH MUSCLE CONTRACTION%REACTOME%R-HSA-445355.3 Smooth Muscle Contraction ITGB5 LMOD1 DYSF MYL6B ACTG2 MYL12A MYL12B MYLK CALD1 ANXA6 MYL10 MYH11 ANXA1 CAV3 TPM4 ANXA2 TPM3 PXN TPM2 TPM1 ITGA1 SORBS1 SORBS3 ACTA2 PAK1 MYLPF MYL5 MYL6 MYL7 GUCY1A3 MYL9 GUCY1B3 VCL GUCY1A2 PAK2 TLN1 TRIM72 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY%REACTOME DATABASE ID RELEASE 72%2564830 Cytosolic iron-sulfur cluster assembly CIAO1 FAM96B RTEL1 POLD1 NDOR1 ABCB7 MMS19 NARFL BRIP1 NUBP1 NUBP2 CIAPIN1 ERCC2 INTERLEUKIN-18 SIGNALING%REACTOME DATABASE ID RELEASE 72%9012546 Interleukin-18 signaling IL4 IL18RAP IL37 IL13 IL18R1 IL18BP IL18 ALOX5 SYNTHESIS OF PIPS IN THE NUCLEUS%REACTOME%R-HSA-8847453.2 Synthesis of PIPs in the nucleus PIP4K2A TMEM55B PIP4K2B PIP4K2C ATF6 (ATF6-ALPHA) ACTIVATES CHAPERONE GENES%REACTOME DATABASE ID RELEASE 72%381183 ATF6 (ATF6-alpha) activates chaperone genes CALR HSPA5 NFYA NFYB NFYC DDIT3 ATF6 HSP90B1 ATF4 CONSTITUTIVE SIGNALING BY OVEREXPRESSED ERBB2%REACTOME%R-HSA-9634285.1 Constitutive Signaling by Overexpressed ERBB2 SHC1 HRAS PTPN12 SOS1 ERBB2IP HSP90AA1 CDC37 ERBB2 NRAS ABO BLOOD GROUP BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 72%9033807 ABO blood group biosynthesis FUT2 FUT1 AFLATOXIN ACTIVATION AND DETOXIFICATION%REACTOME%R-HSA-5423646.3 Aflatoxin activation and detoxification GGT7 ACY1 GGT6 CYP3A4 CYP3A5 MGST3 GGT1 MGST1 MGST2 AKR7A2 CYP2A13 AKR7L AKR7A3 DPEP2 DPEP1 DPEP3 CYP1A2 GGT5 ACY3 MAP3K8 (TPL2)-DEPENDENT MAPK1 3 ACTIVATION%REACTOME%R-HSA-5684264.2 MAP3K8 (TPL2)-dependent MAPK1 3 activation CUL1 IKBKB MAP2K1 FBXW11 MAP3K8 CHUK MAP2K4 UBB UBC NFKB1 RPS27A UBA52 BTRC SKP1 TNIP2 IKBKG SYNTHESIS OF (16-20)-HYDROXYEICOSATETRAENOIC ACIDS (HETE)%REACTOME DATABASE ID RELEASE 72%2142816 Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) CYP4A11 CYP4F2 CYP2C19 CYP1B1 CYP2C9 CYP1A2 CYP1A1 CYP2C8 CYP2U1 INLB-MEDIATED ENTRY OF LISTERIA MONOCYTOGENES INTO HOST CELL%REACTOME%R-HSA-8875360.2 InlB-mediated entry of Listeria monocytogenes into host cell SH3GL1 SH3GL2 MET UBB STAM UBC CBL RPS27A UBA52 HGS SH3GL3 SH3KBP1 STAM2 EPS15 ORGANIC ANION TRANSPORT%REACTOME%R-HSA-561048.1 Organic anion transport SLC22A12 SLC22A6 SLC22A8 SLC22A7 SLC22A11 DISEASES ASSOCIATED WITH O-GLYCOSYLATION OF PROTEINS%REACTOME%R-HSA-3906995.2 Diseases associated with O-glycosylation of proteins MUC20 B4GAT1 POMT2 GALNT12 SEMA5A SEMA5B SPON2 SPON1 NOTCH1 THSD7B POMT1 ADAMTSL1 ADAMTS4 ADAMTS5 ADAMTS2 C1GALT1C1 ADAMTS3 ADAMTSL4 ADAMTS1 ADAMTSL3 ADAMTSL2 MUC12 DAG1 MUC13 MUC15 THSD7A ADAMTS8 ADAMTS9 ADAMTS6 ADAMTS7 SBSPON MUCL1 MUC3A POMGNT1 MUC5AC ADAMTS20 NOTCH2 B3GLCT NOTCH3 CFP NOTCH4 ADAMTS12 THBS2 LFNG THSD1 THBS1 THSD4 ADAMTS10 ADAMTS16 ADAMTS15 ADAMTS14 MUC1 ADAMTS13 ADAMTS19 ADAMTS18 LARGE ADAMTS17 MUC7 MUC4 MUC6 GALNT3 MUC17 C1GALT1 MUC5B MUC21 DEFECTIVE CYP24A1 CAUSES HYPERCALCEMIA, INFANTILE (HCAI)%REACTOME%R-HSA-5579010.1 Defective CYP24A1 causes Hypercalcemia, infantile (HCAI) CYP24A1 ORGANIC CATION ANION ZWITTERION TRANSPORT%REACTOME DATABASE ID RELEASE 72%549132 Organic cation anion zwitterion transport SLC22A3 SLC22A5 SLC22A2 SLC22A1 RUNX1 SLC22A12 SLC22A6 SLC22A8 SLC22A7 SLC22A4 SLC22A11 RSC1A1 SLC22A15 SLC22A16 SLC22A18 TACHYKININ RECEPTORS BIND TACHYKININS%REACTOME%R-HSA-380095.2 Tachykinin receptors bind tachykinins TACR2 TACR3 TAC3 TACR1 TAC1 SIGNALING BY ERBB2 KD MUTANTS%REACTOME DATABASE ID RELEASE 72%9664565 Signaling by ERBB2 KD Mutants HRAS NRG1 NRG2 BTC NRG3 NRG4 NRAS HBEGF EREG EGF SHC1 GAB1 PIK3R1 EGFR PIK3CA PLCG1 SOS1 ERBB2IP HSP90AA1 CDC37 ERBB2 DOPAMINE RECEPTORS%REACTOME%R-HSA-390651.2 Dopamine receptors DRD1 DRD5 DRD2 DRD3 DRD4 PROTEIN REPAIR%REACTOME DATABASE ID RELEASE 72%5676934 Protein repair TXN MSRA PCMT1 MSRB2 MSRB3 MSRB1 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1%REACTOME%R-HSA-113501.3 Inhibition of replication initiation of damaged DNA by RB1 E2F1 PPP2CA PPP2CB E2F1 POLA1 POLA2 TFDP1 PRIM2 TFDP2 PPP2R1B RB1 PRIM1 PPP2R1A PPP2R3B REGULATION OF PAK-2P34 ACTIVITY BY PS-GAP RHG10%REACTOME%R-HSA-211728.2 Regulation of PAK-2p34 activity by PS-GAP RHG10 PAK2 ARHGAP10 S PHASE%REACTOME DATABASE ID RELEASE 72%69242 S Phase LIG1 RBBP4 CUL1 RPA1 POLE RPA2 POLD3 RFC1 POLD4 RPA3 POLD1 POLD2 DNA2 RFC5 RFC3 RFC4 RFC2 RBL2 CCNA2 CCNA1 SMC3 TFDP1 TFDP2 ESCO1 ESCO2 CDCA5 PDS5B PDS5A POLE4 RAD21 E2F1 E2F4 STAG1 POLE2 STAG2 POLE3 CCND1 WAPAL SMC1A CDC25B FZR1 GINS1 GINS2 GINS3 GINS4 CDK4 CDKN1A CDKN1B AKT2 PSMD8 AKT3 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 AKT1 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 CCNH PSME4 PSME1 PSME2 UBA52 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 ANAPC15 ANAPC16 PSMB6 ANAPC7 UBE2C PSMB7 UBE2E1 PSMB4 UBE2D1 ANAPC10 PSMB5 ANAPC11 PSMB2 UBB CDC23 PSMB3 CDC26 CDC27 UBC CDC16 PSMB1 ANAPC4 PSMF1 ANAPC5 ANAPC1 RPS27A ANAPC2 RB1 SHFM1 MYC PSMB8 PSMB9 SKP2 PSMC5 CDC25A PSMC6 MAX PSMC3 ORC5 PSMC4 ORC4 PSMC1 ORC6 CDK7 PSMC2 ORC1 ORC3 ORC2 CDT1 CCNE2 CDC6 MNAT1 CCNE1 POLA1 POLA2 LIN54 MCM7 MCM8 GSK3B CKS1B LIN52 MCM3 MCM4 MCM5 PTK6 MCM6 MCM2 PRIM2 LIN37 PRIM1 LIN9 CDC45 E2F5 CABLES1 WEE1 CDK2 SKP1 RBX1 FEN1 PCNA PAOS OXIDISE POLYAMINES TO AMINES%REACTOME DATABASE ID RELEASE 72%141334 PAOs oxidise polyamines to amines PAOX REGULATION OF ORNITHINE DECARBOXYLASE (ODC)%REACTOME DATABASE ID RELEASE 72%350562 Regulation of ornithine decarboxylase (ODC) PSMD3 PSMD1 NQO1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 AZIN1 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 PSMF1 SHFM1 PSMB8 PSMB9 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 OAZ1 OAZ2 OAZ3 ODC1 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 ACTIVATION OF BID AND TRANSLOCATION TO MITOCHONDRIA%REACTOME DATABASE ID RELEASE 72%75108 Activation of BID and translocation to mitochondria GZMB NMT1 BID CASP8 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY%REACTOME DATABASE ID RELEASE 72%442380 Zinc influx into cells by the SLC39 gene family SLC39A10 SLC39A14 SLC39A6 SLC39A5 SLC39A8 SLC39A7 SLC39A2 SLC39A1 SLC39A4 SLC39A3 HIGHLY SODIUM PERMEABLE POSTSYNAPTIC ACETYLCHOLINE NICOTINIC RECEPTORS%REACTOME DATABASE ID RELEASE 72%629587 Highly sodium permeable postsynaptic acetylcholine nicotinic receptors CHRNB2 CHRND CHRNB4 CHRNA3 CHRNG CHRNA4 CHRNE CLEAVAGE OF THE DAMAGED PURINE%REACTOME%R-HSA-110331.2 Cleavage of the damaged purine TINF2 NEIL3 TERF2IP HIST1H2AE HIST1H2AD HIST3H2BB HIST1H2AC ACD HIST1H2AB HIST1H2AJ HIST1H2BF HIST1H2BE HIST1H2BH HIST1H2BG HIST1H2BB HIST1H2BA HIST1H2BD OGG1 HIST1H2BC H2AFB1 HIST3H3 TERF1 TERF2 POT1 HIST1H4K HIST1H4L H2BFS HIST1H4A HIST1H4B HIST1H4H HIST1H4I HIST1H4J HIST1H4C HIST1H4D HIST1H4E MPG HIST1H4F HIST2H2AA3 HIST2H2AA4 HIST2H2AC H2AFJ H2AFZ H2AFX H2AFV HIST2H2BE HIST4H4 HIST1H2BN HIST1H2BM HIST1H2BO HIST1H2BJ HIST1H2BI HIST1H2BL HIST1H2BK HIST2H4A HIST2H4B SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%R-HSA-3315487.2 SMAD2 3 MH2 Domain Mutants in Cancer SMAD2 SMAD3 SMAD4 DEFECTIVE SLC2A9 CAUSES HYPOURICEMIA RENAL 2 (RHUC2)%REACTOME DATABASE ID RELEASE 72%5619047 Defective SLC2A9 causes hypouricemia renal 2 (RHUC2) SLC2A9 DEFECTIVE SLC12A6 CAUSES AGENESIS OF THE CORPUS CALLOSUM, WITH PERIPHERAL NEUROPATHY (ACCPN)%REACTOME DATABASE ID RELEASE 72%5619039 Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN) SLC12A6 DEFECTIVE CSF2RB CAUSES PULMONARY SURFACTANT METABOLISM DYSFUNCTION 5 (SMDP5)%REACTOME DATABASE ID RELEASE 72%5688849 Defective CSF2RB causes pulmonary surfactant metabolism dysfunction 5 (SMDP5) SFTA3 SFTPB SFTPA2 SFTPC SFTPD CSF2RB SFTPA1 CSF2RA ERBB2 ACTIVATES PTK6 SIGNALING%REACTOME%R-HSA-8847993.1 ERBB2 Activates PTK6 Signaling NRG1 PTK6 EGFR NRG2 BTC NRG3 NRG4 ERBB2 HBEGF EREG EGF RUNX3 REGULATES NOTCH SIGNALING%REACTOME DATABASE ID RELEASE 72%8941856 RUNX3 regulates NOTCH signaling MAML2 MAML1 EP300 RBPJ RUNX3 KAT2B HES1 KAT2A JAG1 SNW1 MAML3 MAMLD1 CREBBP NOTCH1 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1)%REACTOME%R-HSA-381771.2 Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) GRP GNG13 GPR119 PCSK1 DPP4 GNAT3 SEC11A SEC11C TCF7L2 GNB3 CDX2 FFAR4 LEP CTNNB1 FFAR1 PAX6 SPCS3 SPCS2 SPCS1 GCG REGULATION OF COMPLEMENT CASCADE%REACTOME%R-HSA-977606.5 Regulation of Complement cascade C3AR1 PROS1 IGHG4 IGHG1 IGHG2 IGKV1-12 F2 IGKV2D-28 IGKV4-1 IGKV2D-30 SERPING1 CPB2 IGKV3-11 IGKV2-28 CD81 C4BPA C4BPB C8B C8A CLU C4B C4A C8G IGKV3D-20 CR2 CR1 CD46 C1QB C1QA C1S CFH C1R C5AR2 C5AR1 CFI C4B_2 CPN2 CPN1 C2 VTN C5 C6 C7 C9 CD19 CD59 ELANE C3 CD55 CFHR2 CFB CFHR1 IGKV5-2 CFHR4 CFHR3 CFHR5 C1QC RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN INTERLEUKIN SIGNALING%REACTOME DATABASE ID RELEASE 72%8939247 RUNX1 regulates transcription of genes involved in interleukin signaling ELF1 IL3 CBFB LIFR RUNX1 POU5F1 (OCT4), SOX2, NANOG ACTIVATE GENES RELATED TO PROLIFERATION%REACTOME DATABASE ID RELEASE 72%2892247 POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation SOX2 STAT3 FOXD3 SALL1 DPPA4 ZIC3 FGF2 SALL4 NANOG EPHA1 TDGF1 POU5F1 VIRUS ASSEMBLY AND RELEASE%REACTOME%R-HSA-168268.3 Virus Assembly and Release CALR CANX DEFECTIVE SLC40A1 CAUSES HEMOCHROMATOSIS 4 (HFE4) (MACROPHAGES)%REACTOME DATABASE ID RELEASE 72%5619049 Defective SLC40A1 causes hemochromatosis 4 (HFE4) (macrophages) SLC40A1 CP G ALPHA (S) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 72%418555 G alpha (s) signalling events HTR6 HTR7 GNAS HTR4 ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ARRB1 ADCY5 AVP GNAT3 GNAZ GNG10 GNG12 GNG11 GNG13 GNB2 GNB1 GNB4 GNB3 GNB5 GNGT1 GNGT2 GNAI3 GNAI1 GNAI2 GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 OR11H2 OR11H1 OR2M7 OR11H4 OR2M5 OR2M4 OR2M3 OR1K1 OR2M2 OR4K17 OR4Q3 OR2AE1 OR11H6 OR2L8 OR1J4 OR11G2 OR2L5 OR1J2 OR2L3 OR1J1 OR2L2 OR4P4 OR10AD1 OR5R1 OR6T1 OR4K15 OR4K14 OR4K13 OR13J1 OR1I1 OR2K2 OR6S1 OR5M11 OR5M10 OR10D3 OR8B12 OR14K1 OR2J3 OR4N5 OR2J2 OR4N4 OR2J1 OR4N2 OR5P3 OR5P2 OR10C1 OR10J1 OR11L1 OR10J3 OR10J5 OR5W2 OR6Y1 OR52B2 OR52B6 OR1N2 OR1N1 OR5V1 OR6X1 OR52A1 OR52A5 OR10H1 OR10H3 OR10H2 OR10H5 OR10H4 OR1M1 OR4S2 GNAL OR4S1 ADRBK2 OR2AG1 OR2AG2 OR10G2 OR14A16 OR1L8 OR10G4 OR1L6 OR10G3 OR1L4 OR1L3 OR1L1 OR5T3 OR5T2 OR5T1 OR6V1 OR10G6 OR10G8 OR10G7 OR10G9 OR52W1 OR1S2 OR1S1 OR13D1 OR14C36 OR5AS1 OR2T8 OR2T7 OR2T6 OR2T5 OR2T4 OR2T3 OR2T2 OR13C9 OR2T1 OR13C8 OR4X2 OR2L13 OR4X1 OR9A4 OR51T1 OR9A2 OR13C3 OR13C2 OR13C5 OR13C4 OR5AR1 OR2S2 OR1Q1 OR51S1 OR4A47 OR5B21 REEP1 REEP5 REEP4 REEP3 REEP2 REEP6 OR13A1 OR7E24 OR7A10 OR14J1 OR13H1 OR2Y1 OR56B1 OR8D4 OR8D2 OR56B4 OR8D1 OR7A17 OR6C70 OR6C76 OR6C75 OR6C74 OR13G1 OR14I1 OR10A7 OR56A5 OR7A5 OR10A2 OR10A4 OR56A4 OR10A3 OR56A3 OR10A6 OR10A5 OR56A1 OR6C65 OR2W3 OR8B8 OR2W1 OR8B4 OR8B3 OR6C68 OR13F1 OR8B2 OR12D3 OR12D2 OR5AU1 OR51V1 OR2V2 OR2V1 OR11A1 OR8A1 OR7G2 OR8I2 OR7G1 OR9K2 OR52N1 OR52N5 OR52N4 OR52N2 OR51L1 OR5D18 OR10W1 OR2A42 OR5D16 OR5B3 OR5B2 OR5D14 OR8H3 OR5D13 OR8H2 OR8H1 OR52M1 OR10V1 OR4C12 OR2AT4 OR6C6 OR4C11 OR6C4 OR5A2 OR8G5 OR6C3 OR4C16 VIPR1 OR5AK2 VIPR2 OR5A1 SCT OR6C2 RXFP1 OR4C15 RXFP2 OR6C1 OR4C13 OR8G1 GPR176 OR9I1 OR10T2 OR51J1 OR52L1 PTGDR OR7D4 LHCGR OR6B3 TAAR8 OR6B2 TAAR9 OR6B1 TAAR6 OR7D2 TAAR5 OR2A25 TAAR2 OR51I2 TAAR1 OR10S1 ADCYAP1 OR52K2 OR51I1 OR52K1 PDE3A IAPP OR4D11 ADCYAP1R1 OR2Z1 OR4D10 CALCA CALCRL OR2A12 OR6A2 CALCB OR9G4 GIPR OR7C2 GPR83 OR7C1 OR9G1 ADRB1 GPR84 OR2A14 OR2A1 ADRB2 CRHR1 OR4E2 CRHR2 OR51Q1 GHRHR OR4D9 GCG MC2R OR5AP2 OR5B12 CALCR OR4D6 HRH2 DRD1 OR4D5 OR5B17 DRD5 OR4D2 OR4D1 OR5F1 GPR15 OR10Z1 OR52R1 OR4C6 MC1R OR4C5 RLN2 OR3A3 RLN3 OR3A2 GPR27 OR4A15 GPR25 OR4C3 GPR20 OR14A2 ADM OR3A1 OR4A16 PTH1R OR8K5 MC4R OR8K3 OR8K1 OR5AN1 INSL3 OR4B1 OR4C46 GPR39 OR8J3 OR6F1 FSHB OR8J1 GPR32 OR51M1 AVPR2 OR10X1 OR4A5 GLP2R OR7G3 OR5C1 GPBAR1 OR1C1 PTH2R OR5K4 OR5K3 GIP MC3R OR5K2 OR51D1 ADORA2A OR5K1 ADRB3 OR6M1 ADORA2B OR2T12 FSHR OR2T10 CRH OR2T11 OR5H15 NPSR1 OR5H14 PTGER4 PDE8B RAMP2 PDE8A RAMP3 OR2D3 GPR45 OR2D2 PTH OR1B1 PTGER2 OR52E4 OR5J2 PTH2 OR52E2 OR5AC2 PTHLH NPS OR52E8 GPR150 OR52E6 OR52E5 GPHA2 OR2C3 P2RY11 OR1A2 OR6K6 SCTR OR1A1 OR2C1 TSHR OR51B2 GHRH OR6K3 ADM2 OR6K2 MC5R OR5I1 OR52D1 VIP RAMP1 OR9Q2 GPHB5 OR9Q1 OR2AK2 GRK5 GRK6 OR51B6 OR51B5 OR51B4 OR2B6 OR4F6 OR4F5 OR5H6 OR2B3 OR10K2 OR4F4 OR2B2 OR10K1 OR4F3 OR5H2 OR5H1 OR6J1 OR2AJ1 OR51A4 OR2A7 OR51A2 OR2A5 OR2A4 OR51A7 OR2A2 RTP4 RTP5 OR52J3 RTP2 OR51H1 RTP3 RTP1 OR1G1 OR4M2 OR4M1 OR10R2 OR10AG1 OR6Q1 OR8U1 PDE4A OR51G2 OR52I2 OR51G1 OR52I1 OR1F1 PDE4D OR2H2 PDE4C OR2H1 OR4L1 OR10Q1 OR6P1 OR2B11 OR2AP1 OR51F2 OR2G6 OR51F1 OR5M9 OR52H1 OR5M8 OR2G3 OR1E2 OR4K5 CGA OR2G2 OR1E1 OR5M3 OR4K2 OR4K1 OR5M1 OR10P1 OR2T34 OR8S1 OR2T35 OR2T33 OR4F29 OR4F21 OR1D5 OR2T27 OR51E1 OR1D2 OR2F2 OR2F1 OR2T29 OR51E2 OR5L2 OR6N2 OR5L1 OR6N1 OR4F17 OR4F16 OR4F15 PDE7B PDE7A CYSLTR2 TSHB POMC PDE1B PDE1A PDE2A PDE11A PDE10A SRC PTGIR LHB ARRB2 ADRBK1 PDE3B ADCY9 GLP1R BIOSYNTHESIS OF ASPIRIN-TRIGGERED D-SERIES RESOLVINS%REACTOME DATABASE ID RELEASE 72%9020265 Biosynthesis of aspirin-triggered D-series resolvins LTA4H ALOX5 DEGRADATION OF GLI2 BY THE PROTEASOME%REACTOME DATABASE ID RELEASE 72%5610783 Degradation of GLI2 by the proteasome PSMD3 CUL1 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 GLI2 PSMA2 PSME3 SUFU PSME4 PSME1 PSME2 UBA52 PSMD10 PSMB11 PSMD12 PRKACG PSMD11 PRKACA PSMD14 PRKACB PSMD13 PSMA7 PSMB10 CSNK1A1 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 UBB PSMB3 UBC PSMB1 PSMF1 RPS27A SHFM1 PSMB8 PSMB9 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 GSK3B BTRC SKP1 PSMD8 PSMD9 PSMD6 RBX1 PSMD7 PSMD4 PSMD5 PSMD2 FOXO-MEDIATED TRANSCRIPTION%REACTOME%R-HSA-9614085.2 FOXO-mediated transcription AGRP AKT1 BCL2L11 SIRT3 YWHAG YWHAZ TXNIP RBL2 SMAD2 SOD2 SMAD3 FOXO6 FOXO4 G6PC EP300 CAV1 STK11 FOXO1 NR3C1 FOXO3 PCK1 NFYA NFYB NFYC INS TXN KLF4 FASLG PCBP4 GCK SFN SIN3A POMC PPARGC1A CREBBP GADD45A CITED2 SIRT1 SMAD4 BCL6 KAT2B DDIT3 CDKN1A BTG1 CDKN1B MSTN IGFBP1 HDAC2 YWHAB SREBF1 TRIM63 AKT2 CAT HDAC1 AKT3 FOXG1 RETN ATXN3 NPY PLXNA4 ABCA6 BBC3 YWHAQ FBXO32 PINK1 CCNG2 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF%REACTOME DATABASE ID RELEASE 72%3359458 Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF LMBRD1 THE ROLE OF GTSE1 IN G2 M PROGRESSION AFTER G2 CHECKPOINT%REACTOME%R-HSA-8852276.2 The role of GTSE1 in G2 M progression after G2 checkpoint PSMD3 PSMD1 GTSE1 FKBPL PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 UBA52 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PLK1 PSMB4 PSMB5 PSMB2 CCNB1 UBB PSMB3 UBC PSMB1 CDK1 PSMF1 RPS27A SHFM1 PSMB8 PSMB9 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 HSP90AB1 TP53 HSP90AA1 CDKN1A MAPRE1 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 CCNB2 INTERLEUKIN-1 FAMILY SIGNALING%REACTOME%R-HSA-446652.7 Interleukin-1 family signaling CUL1 CASP1 MAP2K1 PTPN2 MAPK8 APP IL1RN IL36A IL36B IL1R1 RELA IL1R2 IL36RN IL36G IL1F10 TOLLIP PTPN20 PTPN23 IL1RL1 IL1RL2 IRAK3 MAP3K3 IL33 PTPN18 SIGIRR PTPN14 CTSG PTPN9 PTPN7 PTPN4 PTPN5 HMGB1 IKBKB NKIRAS1 NKIRAS2 MAP3K8 CHUK MAP2K4 RIPK2 IRAK4 PELI1 UBE2V1 PELI3 PELI2 NFKB1 NOD1 NFKB2 NOD2 AGER IRAK1 S100A12 S100B TNIP2 SAA1 MYD88 NFKBIB IL4 IL18RAP FBXW11 IL37 IL13 IL18R1 IL18BP PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 PTPN12 PTPN11 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 IL18 PSMA2 PSME3 IL1A PSME4 IL1B PTPN6 PSME1 PSME2 UBA52 SMAD3 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 NFKBIA IKBKG PSMD13 PSMA7 PSMB10 PSMA8 PTPN13 PSMB6 PSMB7 PSMB4 PSMB5 IL1RAPL1 PSMB2 UBB PSMB3 UBC PSMB1 PSMF1 RPS27A SHFM1 PSMB8 PSMB9 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 UBE2N MAP2K6 TBK1 ALOX5 BTRC SKP1 STAT3 IRAK2 TRAF6 RBX1 TAB3 SQSTM1 TAB2 TAB1 MAP3K7 INTERLEUKIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 72%9020702 Interleukin-1 signaling CUL1 MAP2K1 APP IL1RN IL1R1 RELA IL1R2 TOLLIP IRAK3 MAP3K3 HMGB1 IKBKB NKIRAS1 NKIRAS2 MAP3K8 CHUK MAP2K4 RIPK2 IRAK4 PELI1 UBE2V1 PELI3 PELI2 NFKB1 NOD1 NFKB2 NOD2 AGER IRAK1 S100A12 S100B TNIP2 SAA1 MYD88 NFKBIB FBXW11 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 IL1A PSME4 IL1B PSME1 PSME2 UBA52 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 NFKBIA IKBKG PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 UBB PSMB3 UBC PSMB1 PSMF1 RPS27A SHFM1 PSMB8 PSMB9 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 UBE2N MAP2K6 BTRC SKP1 IRAK2 TRAF6 RBX1 TAB3 SQSTM1 TAB2 TAB1 MAP3K7 PURINE SALVAGE%REACTOME DATABASE ID RELEASE 72%74217 Purine salvage HPRT1 DCK DGUOK APRT PNP GMPR2 AMPD1 AMPD2 ADAL AMPD3 ADA ADK GMPR SIGNALING BY NOTCH%REACTOME DATABASE ID RELEASE 72%157118 Signaling by NOTCH NCSTN CUL1 APH1B TFDP1 PSENEN NUMB TFDP2 ARRB1 ITCH E2F1 ADAM17 TNRC6C TNRC6A TNRC6B GZMB E2F3 ACTA2 FURIN CDK8 HIST1H2AE HIST1H2AD HIST3H2BB HIST1H2AC HIST1H2AB HIST1H2AJ HIST2H3A HIST1H2BF HIST1H2BE HIST1H2BH HIST1H2BG HIST2H3D HIST1H2BB HIST1H2BA HIST2H3C FABP7 HIST1H2BD HIST1H2BC H2AFB1 HIST1H3J HIST1H3A HIST1H3F HIST1H3G HIST1H3H HIST1H3I SIRT6 HIST1H3B HIST1H3C HIST1H3D HIST1H3E H3F3B MYC HIST1H4K HIST1H4L H3F3A NOTCH1 H2BFS MAML2 ST3GAL4 HIST1H4A TLE4 MAML1 ST3GAL6 HIST1H4B TLE2 HIST1H4H TLE1 HIST1H4I RBPJ HIST1H4J HIST1H4C HES1 ST3GAL3 HIST1H4D HIST1H4E HIST1H4F HIST2H2AA3 SNW1 HIST2H2AA4 EGF MAML3 HIST2H2AC EGFR MAMLD1 H2AFJ H2AFZ NCOR2 H2AFX NCOR1 HDAC3 H2AFV HDAC10 HIST2H2BE KAT2B KAT2A HIST4H4 DTX4 HIST1H2BN HIST1H2BM HDAC2 HIST1H2BO HIST1H2BJ HDAC1 HIST1H2BI HIST1H2BL HIST1H2BK PBX1 HIST2H4A HIST2H4B TBL1X CCNC TBL1XR1 B4GALT1 CCND1 WWP2 DNER DLGAP5 FCER2 TACC3 POGLUT1 PLXND1 WWC1 POFUT1 DTX1 DTX2 CNTN1 TP53 FLT4 YBX1 MDK PTCRA ELF3 DLK1 NOTCH2 JUN NOTCH3 NOTCH4 RFNG CREBBP LFNG MFNG TMED2 RAB6A MOV10 AGO3 AGO4 AGO1 AGO2 ATP2A3 ATP2A2 ATP2A1 HDAC8 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 AKT1 PSMD1 ADAM10 YWHAZ PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 RUNX1 PSME3 ARRB2 PSME1 PSME2 NBEA UBA52 SMAD3 PSMD10 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMB6 EP300 PSMB7 PSMB4 PSMB5 PSMB2 UBB PSMB3 UBC PSMB1 PSMF1 CREB1 RPS27A SHFM1 PSMB8 PSMB9 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 STAT1 HIF1A HDAC11 HEY1 HEY2 HDAC4 HDAC5 DLL1 HDAC9 HDAC6 HDAC7 DLL4 NEURL1B HES5 JAG2 JAG1 PRKCI MIB2 MIB1 HEYL NEURL1 SKP1 RBX1 PSEN2 SEL1L PSEN1 APH1A DEFECTIVE SLC6A3 CAUSES PARKINSONISM-DYSTONIA INFANTILE (PKDYS)%REACTOME%R-HSA-5660724.1 Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) SLC6A3 PI3K CASCADE%REACTOME DATABASE ID RELEASE 72%109704 PI3K Cascade PDPK1 FRS2 PTPN11 FGF16 TRIB3 FGF7 FGF18 TLR9 GAB1 PIK3R1 PIK3R2 FGF6 PIK3CA FGF9 FGF20 FGF1 FGF2 FGF23 FGF3 FGF22 PIK3C3 FGF10 FGF4 PIK3R4 KLB IRS1 FLT3 PDE3B IRS2 THEM4 FLT3LG GAB2 FGF19 PIK3CB FGFR4 AKT2 REGULATION OF TNFR1 SIGNALING%REACTOME DATABASE ID RELEASE 72%5357905 Regulation of TNFR1 signaling USP2 IKBKB SHARPIN CHUK GNB2L1 CYLD OTUD7B CASP8 TRADD TNFAIP3 UBA52 RIPK1 TRAF2 IKBKG TRAF1 TNFRSF1A TAX1BP1 SPPL2B SPPL2A BIRC2 TNF BIRC3 RNF31 UBB XIAP USP4 UBC CLIP3 RPS27A USP21 RBCK1 OTULIN FGFR3B LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 72%190371 FGFR3b ligand binding and activation FGF9 FGF20 FGF1 FGF18 FGFR2 MUTANT RECEPTOR ACTIVATION%REACTOME%R-HSA-1839126.2 FGFR2 mutant receptor activation GTF2F1 GTF2F2 POLR2A POLR2B POLR2C POLR2D POLR2G POLR2E POLR2F FGF16 FGF7 POLR2H POLR2I POLR2J FGF18 POLR2K POLR2L FGFR2 FGF6 FGF9 FGF20 FGF1 FGF2 FGF23 FGF3 FGF22 FGF10 FGF4 NCBP1 NCBP2 G2 M TRANSITION%REACTOME DATABASE ID RELEASE 72%69275 G2 M Transition RBBP4 CUL1 PRKAR2B GTSE1 FKBPL YWHAG OFD1 CCNA2 CCNA1 PPP2R1B PPP2R1A HMMR PRKACA AURKA PPP2CA PPP2CB CDC25B CENPF TP53 CEP57 CETN2 CEP164 CCP110 PPP1CB ACTR1A PCM1 CNTRL CEP250 NEK2 NINL CEP290 RAB8A CDK5RAP2 CEP135 BORA TPX2 PPP1R12A FBXW11 PPME1 TUBB PHLDA1 CEP131 TUBGCP2 HAUS4 TUBGCP5 HAUS3 TUBGCP6 HAUS6 CSNK1D TUBGCP3 TUBGCP4 HAUS5 CSNK1E FBXL7 TUBG2 TUBG1 DYNLL1 MZT2B CDKN1A CKAP5 MZT2A HAUS2 NME7 HAUS1 LCMT1 AKAP9 CDK11A CEP63 FBXL18 MAPRE1 MZT1 AJUBA SFI1 PSMD8 OPTN PSMD9 PAFAH1B1 PSMD6 SDCCAG8 XPO1 DYNC1I2 PSMD7 DCTN2 PSMD4 SSNA1 PSMD5 DCTN3 PSMD2 CCNB2 HAUS8 PSMD3 HAUS7 CEP70 PSMD1 CEP72 CEP192 PCNT CEP76 CLASP1 CEP78 PLK4 PSMA5 PSMA6 DYNC1H1 ODF2 PSMA3 PSMA4 CEP152 PSMA1 NDE1 NEDD1 FGFR1OP PSMA2 PSME3 CEP41 CCNH PSME4 PSME1 PSME2 UBA52 PSMD10 PSMB11 PSMD12 PPP2R2A PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 EP300 PSMB6 PSMB7 PLK1 PSMB4 CENPJ PSMB5 PSMB2 CCNB1 UBB PSMB3 UBC CDK1 PSMB1 PSMF1 RPS27A TUBA4A SHFM1 PSMB8 PSMB9 PSMC5 CDC25A PSMC6 PSMC3 PSMC4 PSMC1 CDK7 PSMC2 CDC25C MNAT1 HSP90AB1 LIN54 LIN52 PKMYT1 FOXM1 TUBA1A MYBL2 LIN37 HSP90AA1 LIN9 PPP2R3B WEE1 CDK2 BTRC SKP1 YWHAE TUBB4B TUBB4A RBX1 MYD88 DEFICIENCY (TLR2 4)%REACTOME DATABASE ID RELEASE 72%5602498 MyD88 deficiency (TLR2 4) BTK CD36 TIRAP TLR1 LY96 CD14 TLR6 TLR4 MYD88 TLR2 BIOSYNTHESIS OF DPAN-3-DERIVED MARESINS%REACTOME%R-HSA-9026290.1 Biosynthesis of DPAn-3-derived maresins ALOX12 ALOX5 DAG AND IP3 SIGNALING%REACTOME DATABASE ID RELEASE 72%1489509 DAG and IP3 signaling CAMK2D CAMK2A PRKAR2B PRKAR2A PRKCD PRKCA CAMK2G PRKCG ITPR1 NBEA ITPR2 ITPR3 CAMK4 CAMKK1 PLCG1 ADCY4 CAMKK2 ADCY3 PRKACG ADCY2 ADCY1 PRKACA ADCY8 PRKACB ADCY7 ADCY6 PDE1B ADCY5 PDE1C PDE1A ADRBK1 AHCYL1 PRKX KPNA2 CREB1 PRKCE ADCY9 PRKAR1B PRKAR1A CAMK2B GOLGI-TO-ER RETROGRADE TRANSPORT%REACTOME DATABASE ID RELEASE 72%8856688 Golgi-to-ER retrograde transport NBAS RAB1B DCTN4 KIF3A STX18 BNIP1 GALNT2 GALNT1 ARCN1 CAPZA3 KIF26A KIF26B CAPZA1 CAPZA2 RAB18 RAB3GAP2 COPG2 NSF COPG1 ACTR10 RAB3GAP1 DYNC1LI1 DYNC1LI2 ARF4 ZW10 KIF5B KIF5A KIF18A NAPA DYNLL2 KIF2A KIF2C PLA2G6 KIF2B NAPB NAPG GBF1 DYNC1I1 CENPE ACTR1A TMED2 RAB6A PLA2G4A RACGAP1 DYNLL1 ARF3 ARF1 AGPAT3 PAFAH1B1 DYNC1I2 DCTN2 DCTN3 DYNC1H1 KDELR1 KIF21A KIF21B KIFAP3 RINT1 KIF16B KDELR2 KIF20A KIF20B COPB2 COPA TMED10 COPB1 KLC1 KLC4 KLC3 KLC2 KIF3B KIF3C RAB6B SURF4 KIF18B DCTN1 KIF4B KIF4A COPE KIF11 USE1 BICD1 BICD2 KIF15 KIF19 CAPZB KIF13B TMED3 KIF1C KIF1B KIF1A TMED7 TMED9 KIF25 COPZ2 KIF23 KIF22 ARFGAP3 KIF6 ARFGAP1 KIF27 COPZ1 ARFGAP2 KIF9 KIFC2 KIFC1 SEC22B PAFAH1B3 ARF5 PAFAH1B2 KDELR3 DCTN6 RAB1A DCTN5 CARNITINE SYNTHESIS%REACTOME DATABASE ID RELEASE 72%71262 Carnitine synthesis SHMT1 BBOX1 ALDH9A1 TMLHE SMAD4 MH2 DOMAIN MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 72%3311021 SMAD4 MH2 Domain Mutants in Cancer SMAD2 SMAD3 SMAD4 MRNA EDITING: C TO U CONVERSION%REACTOME%R-HSA-72200.4 mRNA Editing: C to U Conversion APOBEC3H A1CF APOBEC3A APOBEC3B APOBEC1 APOBEC3C APOBEC2 APOBEC4 TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR%REACTOME%R-HSA-1679131.1 Trafficking and processing of endosomal TLR UNC93B1 TLR9 CTSV TLR8 CNPY3 TLR7 CTSS HSP90B1 CTSL CTSK CTSB LGMN TLR3 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME DATABASE ID RELEASE 72%427359 SIRT1 negatively regulates rRNA expression TAF1B TAF1C TAF1A RRP8 HIST1H2AE HIST1H2AD HIST3H2BB HIST1H2AC HIST1H2AB HIST1H2AJ HIST2H3A HIST1H2BF HIST1H2BE HIST1H2BH HIST1H2BG HIST2H3D HIST1H2BB HIST1H2BA HIST2H3C HIST1H2BD HIST1H2BC H2AFB1 HIST1H3J HIST1H3A HIST1H3F HIST1H3G HIST1H3H HIST1H3I HIST1H3B HIST1H3C HIST1H3D HIST1H3E H3F3B HIST1H4K HIST1H4L H3F3A H2BFS HIST1H4A HIST1H4B HIST1H4H HIST1H4I HIST1H4J HIST1H4C HIST1H4D HIST1H4E HIST1H4F HIST2H2AA3 HIST2H2AA4 SUV39H1 HIST2H2AC H2AFJ TBP H2AFZ H2AFX H2AFV SIRT1 HIST2H2BE HIST4H4 HIST1H2BN HIST1H2BM HIST1H2BO HIST1H2BJ HIST1H2BI HIST1H2BL HIST1H2BK HIST2H4A TAF1D HIST2H4B SUPPRESSION OF APOPTOSIS%REACTOME DATABASE ID RELEASE 72%9635465 Suppression of apoptosis TRIM27 RNF213 GSK3A SFPQ MAPK1 CTSG MAPK3 CELLULAR RESPONSES TO EXTERNAL STIMULI%REACTOME%R-HSA-8953897.4 Cellular responses to external stimuli DCTN4 RPS4X RPS3A CAPZA3 CSRP1 GPX2 SNCB CAPZA1 CAPZA2 ACTR10 CCNA2 CCNA1 TFDP1 TFDP2 DYNC1LI1 DYNC1LI2 E2F1 BMI1 RNF2 CBX8 PHC2 PHC1 RING1 TXNRD1 CBX4 CBX2 DYNLL2 TNRC6C PHC3 RAD50 TNRC6A TNRC6B DYNC1I1 FZR1 E2F2 E2F3 RPLP1 RPLP0 RPLP2 HSPA9 RPS27L SOD2 VHL AR ANAPC15 ATF5 ANAPC16 ATF3 ANAPC7 ASF1A UBE2C SEH1L NPRL2 UBE2E1 HSPA4L RPL22L1 UBE2D1 NPRL3 ANAPC10 ANAPC11 PRDX3 HSPH1 WDR59 CDC23 ST13 CDC26 EIF2AK1 CDC27 EIF2AK4 CDC16 PRDX6 NOX4 ANAPC4 NOX5 ANAPC5 MIOS ANAPC1 CRYAB ANAPC2 HSPA14 HSPA13 RB1 WDR24 C11orf73 UBN1 CDKN2D CDKN2B CDKN2C GATSL3 HSPA1L EPO SESN1 MAP3K5 ERF TNIK FKBP5 STIP1 BAG5 BAG2 HSP90AB1 BAG3 BAG1 IGFBP7 C7orf60 HIF1AN GPX3 GPX6 GPX5 GPX8 GPX7 DNAJC2 IMPACT ARNT DNAJC7 PPP1R15A CEBPB CEBPG DNAJB6 GCN1L1 SH3BP4 FNIP1 FNIP2 ATOX1 DNAJA1 DNAJA4 DNAJA2 MT1M NUDT2 MT1X CCAR2 MT2A C12orf66 MT1A MT1F MT1G MT1H MT1B MT1E HSPA12A HSPA12B VENTX MINK1 ITFG2 KPTN DEPDC5 HIRA STAT3 MAP4K4 IFNB1 VEGFA ETS1 ETS2 NR3C2 GATSL2 SZT2 RPS19BP1 HIGD1A CBX6 RPA1 HSPA4 RPA2 HSPA6 HMGA2 HSPA2 MT4 RPA3 MT3 CXCL8 HSPB8 RPL23A CABIN1 FLCN SOD3 SOD1 CCS NUP107 NUP188 HMGA1 NUP62 NDC1 NUP214 RELA SEC13 NUP133 NUP210 ERO1L NUP93 NUP50 NUP54 POM121 NUP205 AAAS NUP160 NUP85 TPR RPL27A NUP88 NUP43 RAE1 RANBP2 EP400 NUP155 HSBP1 NFKB1 HSF1 NUP153 CDK4 NUP35 NUPL2 NUP37 KDM6B NCF1 NCF2 NCF4 GSTP1 PGR MLST8 FKBP4 CYBB CYBA MAPKAPK3 TRIB3 CDK6 ATF2 RPS6KA3 RPS6KA2 RPS6KA1 EP300 MTOR FOS MAPKAPK2 SP1 HSPA5 MAPK7 MAPK1 MAPK3 MAPK14 MAPK11 ID1 RPL26L1 RPL4 RPL5 HSP90AA1 RPL30 RPL3 RPL32 RPL31 RPL34 RPL8 RPL9 RPL6 RPL7 RPL36 RPL35 RPL38 RPL37 RPL39 RPL21 RPL23 RPL22 VCP RPL24 RPL27 CAMK2B RPL26 BAG4 CAMK2D RPL29 CAMK2A RPL28 CAMK2G RPL41 RPL3L RPL10 RPL12 RPL11 RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 LMNB1 IL6 TXN2 ACTR1A RPS9 RPS7 RPS8 RPS5 RPS6 RPSA DDIT3 DYNLL1 ATF4 AJUBA ASNS DYNC1I2 DCTN2 DCTN3 CA9 RPL7A TINF2 DYNC1H1 GPX1 IL1A EHMT2 RPL37A HIST1H1D HIST1H1E HIST1H2AE HIST1H2AD HIST3H2BB HIST1H1A ACD HIST1H2AC HIST1H1B HIST1H2AB HIST1H1C RPL36A HIST1H2AJ RPL35A HIST2H3A EIF2S2 HIST1H2BF EIF2S1 HIST1H2BE HIST1H2BH EIF2S3 HIST1H2BG HIST2H3D HIST1H2BB HIST1H2BA HIST2H3C HIST1H2BD HIST1H2BC H2AFB1 H1F0 HIST1H3J HIST1H3A HIST1H3F CHAC1 HIST1H3G HIST1H3H RPS4Y2 HIST1H3I RPS4Y1 TERF1 TERF2 HIST1H3B HIST1H3C HIST1H3D HIST1H3E H3F3B POT1 HIST1H4K UBE2D2 UBE2D3 HIST1H4L H3F3A HIF3A LIMD1 CUL2 H2BFS EGLN1 HIST1H4A EGLN3 EGLN2 HIST1H4B WTIP HIST1H4H HIST1H4I HIST1H4J HIST1H4C HIST1H4D HIST1H4E EZH2 HIST1H4F HIST2H2AA3 GSK3B HIST2H2AA4 HIST2H2AC RPL39L H2AFJ DCTN1 EED H2AFZ H2AFX MTF1 H2AFV SIRT1 HIST2H2BE HIST4H4 RPS15A HIST1H2BN HIST1H2BM HIST1H2BO ATP7A HIST1H2BJ CAT HIST1H2BI HIST1H2BL HIST1H2BK HIST2H4A HIST2H4B ATP6V0D1 RBBP4 RPL10L RPL10A RBBP7 TERF2IP FAU SUZ12 MAPK8 HIST3H3 EHMT1 TCIRG1 RPL13A ATP6V1E1 KAT5 ATP6V1E2 ATP6V1G1 ATP6V0B ATP6V0E1 ATP6V1G2 EEF1A1 ATP6V1B2 RRAGA ATP6V0C ATP6V0D2 ATP6V1B1 RRAGC ATP6V1A MAP2K3 MAP2K4 RRAGB RRAGD ATP6V1H TP53 ATP6V0E2 ATP6V1G3 ATP6V1D TXN ATP6V1C1 PRDX2 ATP6V1F ATP6V1C2 MAPK9 PRDX1 MAP2K7 MAPK10 JUN CREBBP MOV10 AGO3 CITED2 AGO4 AGO1 RPS15 RPS14 RPS17 ATM RPS16 RPS19 RPL18A ATR CDKN1A RPL36AL RPS18 CDKN1B RPS11 RPS10 RPS13 PSMD8 PSMD9 RPS12 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 RPTOR PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 UBA52 RPS26 TCEB2 PSMD10 TCEB1 PSMB11 RPS25 PSMD12 RPS28 PSMD11 RPS27 PSMD14 PSMD13 CDKN2A RPS29 PSMA7 MRE11A RPS20 PSMB10 PSMA8 RPS21 RPS24 RPS23 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 LAMTOR2 UBB PSMB3 LAMTOR1 LAMTOR4 GRB10 LAMTOR3 LAMTOR5 UBC PSMB1 PSMF1 RPS27A HSPA8 SHFM1 SESN2 PSMB8 NBN PSMB9 PSMC5 PSMC6 PSMC3 DNAJB1 PSMC4 PSMC1 AQP8 PSMC2 NR3C1 CCNE2 CCNE1 MAPKAPK5 PTGES3 EPAS1 HIF1A SLC38A9 MAP2K6 AKT1S1 CAPZB HDAC6 RHEB CDK2 MDM2 CYCS P4HB MDM4 YWHAE RBX1 DCTN6 DCTN5 DAP12 INTERACTIONS%REACTOME DATABASE ID RELEASE 72%2172127 DAP12 interactions HLA-E VAV2 PLCG2 PIK3R1 PIK3R2 PIK3CA PLCG1 SYK SOS1 KIR3DS1 TREM1 FYN SIRPB1 CLEC5A CD300LB SIGLEC15 SIGLEC14 KIR2DS2 HRAS KIR2DS4 NCR2 CD300E NRAS B2M PIK3CB TREM2 BTK KLRK1 GRAP2 KLRC2 HLA-B TYROBP RAC1 LCP2 HLA-C KLRD1 VAV3 LCK TOLL LIKE RECEPTOR 2 (TLR2) CASCADE%REACTOME%R-HSA-181438.1 Toll Like Receptor 2 (TLR2) Cascade CUL1 MAP2K1 MAPKAPK3 UBA52 MAPK8 PPP2R1B ATF1 PPP2R1A APP ATF2 NFKBIA IKBKG ELK1 RELA RPS6KA3 RPS6KA5 RPS6KA2 RPS6KA1 DUSP4 PPP2R5D MEF2A MEF2C IRAK3 DUSP3 TIRAP TLR1 FOS SIGIRR VRK3 TLR6 UBB TLR2 DUSP6 DUSP7 UBC CREB1 MAPKAPK2 RPS27A MAPK7 MAPK1 MAPK3 PPP2CA HMGB1 PPP2CB IKBKB NKIRAS1 NKIRAS2 MAPK14 MAP3K8 MAP2K3 CHUK MAPK11 MAP2K4 RIPK2 IRAK4 PELI1 UBE2N UBE2V1 PELI3 PELI2 NOD1 NFKB1 NOD2 NFKB2 AGER MAPK9 IRAK1 MAP2K6 S100A12 MAP2K7 MAP3K1 CD36 S100B MAPK10 TNIP2 JUN SAA1 MYD88 NFKBIB FBXW11 SOCS1 BTRC ECSIT SKP1 BTK IRAK2 TRAF6 TAB3 LY96 TAB2 TAB1 MAP3K7 CD14 TLR4 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX%REACTOME DATABASE ID RELEASE 72%204174 Regulation of pyruvate dehydrogenase (PDH) complex PDHB PDPR GSTZ1 RXRA PDHA2 PDHA1 DLD PDP1 PPARD PDP2 DLAT PDK4 PDK3 PDK2 PDK1 PDHX APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS%REACTOME%R-HSA-111465.3 Apoptotic cleavage of cellular proteins CDH1 LMNB1 PRKCD DBNL ROCK1 CASP8 CASP7 FNTA CASP3 SPTAN1 DSP APC GAS2 ADD1 DSG1 PKP1 PRKCQ DSG2 MAPT DSG3 PLEC SATB1 CLSPN PTK2 BCAP31 GSN TJP1 BIRC2 OCLN STK24 CTNNB1 STK26 ACIN1 VIM TJP2 BMX CASP6 PI-3K CASCADE:FGFR2%REACTOME%R-HSA-5654695.2 PI-3K cascade:FGFR2 FRS2 PTPN11 FGF16 FGF7 FGF18 GAB1 PIK3R1 FGF6 PIK3CA FGF9 FGF20 FGF1 FGF2 FGF23 FGF3 FGF22 FGF10 FGF4 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX%REACTOME DATABASE ID RELEASE 72%201722 Formation of the beta-catenin:TCF transactivating complex SMARCA4 MEN1 ASH2L HIST1H2AE HIST1H2AD HIST3H2BB TERT HIST1H2AC HIST1H2AB HIST1H2AJ HIST2H3A HIST1H2BF HIST1H2BE HIST1H2BH EP300 HIST1H2BG HIST2H3D HIST1H2BB HIST1H2BA HIST2H3C HIST1H2BD HIST1H2BC H2AFB1 HIST3H3 HIST1H3J CTNNB1 HIST1H3A HIST1H3F HIST1H3G HIST1H3H HIST1H3I HIST1H3B HIST1H3C KAT5 HIST1H3D HIST1H3E H3F3B MYC HIST1H4K LEO1 HIST1H4L H3F3A H2BFS TLE4 HIST1H4A TLE3 TLE2 HIST1H4B TLE1 HIST1H4H KMT2D HIST1H4I PYGO1 HIST1H4J PYGO2 HIST1H4C TCF7 TCF7L2 HIST1H4D HIST1H4E BCL9L HIST1H4F HIST2H2AA3 BCL9 HIST2H2AA4 RUVBL1 CDC73 HIST2H2AC AXIN2 LEF1 H2AFJ TCF7L1 H2AFZ CREBBP H2AFX H2AFV RUNX3 HIST2H2BE TRRAP HIST4H4 HIST1H2BN RBBP5 HIST1H2BM HIST1H2BO HIST1H2BJ HDAC1 HIST1H2BI HIST1H2BL HIST1H2BK HIST2H4A HIST2H4B REGULATION OF SIGNALING BY CBL%REACTOME DATABASE ID RELEASE 72%912631 Regulation of signaling by CBL RAPGEF1 HCK LYN VAV1 YES1 PIK3R3 BLNK CRKL CRK PIK3CD PIK3R1 PIK3CB CBL PIK3R2 PIK3CA SYK FYN INTERCONVERSION OF 2-OXOGLUTARATE AND 2-HYDROXYGLUTARATE%REACTOME%R-HSA-880009.1 Interconversion of 2-oxoglutarate and 2-hydroxyglutarate D2HGDH L2HGDH ADHFE1 RUNX3 REGULATES RUNX1-MEDIATED TRANSCRIPTION%REACTOME DATABASE ID RELEASE 72%8951911 RUNX3 regulates RUNX1-mediated transcription RUNX3 CBFB CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY%REACTOME%R-HSA-69656.3 Cyclin A:Cdk2-associated events at S phase entry PSMD3 RBBP4 AKT1 CUL1 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 CCNH PSME1 RBL2 PSME2 CCNA2 CCNA1 UBA52 TFDP1 PSMD10 TFDP2 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMB6 PSMB7 E2F1 PSMB4 E2F4 PSMB5 PSMB2 UBB PSMB3 CCND1 UBC PSMB1 PSMF1 RPS27A RB1 SHFM1 MYC PSMB8 PSMB9 SKP2 PSMC5 CDC25A PSMC6 MAX PSMC3 PSMC4 PSMC1 CDK7 PSMC2 CDC25B FZR1 CCNE2 MNAT1 CCNE1 LIN54 CKS1B LIN52 PTK6 CDK4 LIN37 LIN9 E2F5 CABLES1 WEE1 CDK2 CDKN1A CDKN1B AKT2 SKP1 PSMD8 AKT3 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 INTERFERON GAMMA SIGNALING%REACTOME DATABASE ID RELEASE 72%877300 Interferon gamma signaling NCAM1 CAMK2D TRIM48 CAMK2A GBP2 FCGR1B GBP1 PRKCD HLA-DQA2 GBP4 HLA-DQA1 PTPN11 GBP3 TRIM45 CAMK2G HLA-DRB5 VCAM1 HLA-DRB4 TRIM35 HLA-DPB1 HLA-DRA PTPN6 TRIM38 JAK2 TRIM31 HLA-DRB3 HLA-DRB1 TRIM34 OASL SOCS3 TRIM25 JAK1 PML OAS1 IRF3 OAS2 HLA-B OAS3 HLA-C HLA-F HLA-G HLA-E PTPN1 PIAS1 CIITA IFI30 ICAM1 TRIM8 TRIM6 TRIM5 CD44 TRIM29 MT2A TRIM2 TRIM3 TRIM21 TRIM68 SOCS1 TRIM26 IFNG TRIM22 IFNGR1 HLA-DPA1 IFNGR2 GBP6 IRF7 GBP5 TRIM62 GBP7 HLA-A MID1 B2M TRIM17 IRF4 IRF1 IRF2 IRF8 FCGR1A TRIM14 IRF5 IRF6 TRIM10 IRF9 HLA-DQB2 HLA-DQB1 SP100 SUMO1 PTAFR CAMK2B TRIM46 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES)%REACTOME DATABASE ID RELEASE 72%1236978 Cross-presentation of soluble exogenous antigens (endosomes) PSMD3 PSMD1 FCGR1B PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 PSMD10 PSMB11 MRC2 PSMD12 MRC1 PSMD11 CD207 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 PSMF1 SHFM1 PSMB8 PSMB9 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 FCGR1A PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 INTERFERON SIGNALING%REACTOME%R-HSA-913531.2 Interferon Signaling CAMK2D CAMK2A CAMK2G PML SOCS1 IFNG IFNGR1 IFNGR2 FCGR1A UBE2E1 SOCS3 KPNB1 PLCG1 PIAS1 MT2A TRIM21 IRF7 IFNB1 NUP107 NUP188 JAK2 KPNA1 NUP62 NDC1 NUP214 SEC13 NUP133 NUP210 NUP93 NUP50 NUP54 POM121 NUP205 AAAS NUP160 NUP85 TPR NUP88 NUP43 RAE1 RANBP2 NUP155 NUP153 NUP35 NUPL2 CIITA NUP37 IFI30 ICAM1 TRIM8 TRIM6 TRIM5 CD44 TRIM29 TRIM2 TRIM3 TRIM68 TRIM26 TRIM22 HLA-DPA1 GBP6 GBP5 TRIM62 GBP7 HLA-A MID1 B2M TRIM17 IRF4 IRF1 IRF2 IRF8 TRIM14 IRF5 IRF6 TRIM10 IRF9 HLA-DQB2 HLA-DQB1 SP100 PTAFR SUMO1 TRIM46 NCAM1 TRIM48 GBP2 FCGR1B GBP1 PRKCD HLA-DQA2 GBP4 HLA-DQA1 PTPN11 GBP3 TRIM45 HLA-DRB5 VCAM1 HLA-DRB4 TRIM35 HLA-DPB1 HLA-DRA PTPN6 TRIM38 TRIM31 HLA-DRB3 HLA-DRB1 UBA52 TRIM34 EIF4A2 EIF4A1 EIF4E3 UBE2L6 IFIT1 OASL HERC5 UBB TRIM25 KPNA7 KPNA4 ARIH1 UBC KPNA5 IP6K2 KPNA2 KPNA3 JAK1 RPS27A DDX58 PPM1B IFITM3 OAS1 IFITM1 IRF3 IFITM2 PDE12 IFI35 PSMB8 OAS2 IFIT3 HLA-B OAS3 IFIT2 USP41 RSAD2 HLA-C EIF4E2 EIF4A3 BST2 RNASEL MAPK3 HLA-F EGR1 IFNA5 UBA7 HLA-G IFNA4 USP18 HLA-E IFNA7 FLNA IFNA6 FLNB IFNA1 EIF4G1 EIF4E IFNA2 STAT1 IFNA8 MX2 IFI6 MX1 EIF2AK2 STAT2 IFNA13 ISG15 NEDD4 IFNA14 IFNA16 UBE2N IFNA17 SAMHD1 ABCE1 IFNA10 EIF4G3 IFNAR1 EIF4G2 IFNA21 ISG20 XAF1 ADAR PTPN1 TYK2 PIN1 CAMK2B REGULATION OF PTEN LOCALIZATION%REACTOME%R-HSA-8948747.2 Regulation of PTEN localization UBC RPS27A UBA52 PML NEDD4 PTEN UBB XIAP USP7 TRAF6-MEDIATED INDUCTION OF TAK1 COMPLEX WITHIN TLR4 COMPLEX%REACTOME%R-HSA-937072.2 TRAF6-mediated induction of TAK1 complex within TLR4 complex UBB UBC RPS27A UBA52 IRAK2 TRAF6 TICAM2 TAB3 LY96 TAB2 TICAM1 TAB1 CD14 MAP3K7 TLR4 NEUTROPHIL DEGRANULATION%REACTOME%R-HSA-6798695.2 Neutrophil degranulation IQGAP2 APAF1 RAB18 ACTR10 PDXK DYNC1LI1 CPNE1 SNAP23 CPNE3 CTSZ DGAT1 FTH1 DSN1 VAMP8 CSNK2B FTL TLR2 CTSS RAB5C CTSB PLD1 TXNDC5 SLCO4C1 IGF2R PPIA IQGAP1 SLC44A2 LPCAT1 CYB5R3 NRAS AGPAT2 HEXB CFD C3 ARG1 PRCP CD177 FABP5 PRDX6 KPNB1 PRTN3 HSP90AB1 NDUFC2 CCT2 APEH RHOA CCT8 PADI2 TUBB4B HSPA6 GPI ARSA HK3 SIRPB1 CLEC5A TNFRSF1B SIGLEC14 PGAM1 FCGR3B LTA4H ANPEP PLAUR CTSG CTSD ALDOC MME ALDOA ATP6AP2 DIAPH1 ARSB CTSA DBNL RAB27A LRRC7 NFKB1 PFKL CHRNB4 CD36 RAB6A CD44 CYFIP1 GSTP1 AP2A2 ITGAV TYROBP RAC1 PTAFR CYBB CYBA ACAA1 ROCK1 ACLY NCKAP1L SLC27A2 JUP RAB4B KCNAB2 RAP1A DNAJC5 HPSE HLA-B MAPK1 HLA-C BST2 ALAD MAPK14 PGM2 PGM1 GLB1 HSP90AA1 SLC15A4 PTPRJ VCP PSEN1 NCSTN MLEC NEU1 BST1 GAA APRT ASAH1 GPR84 ORMDL3 AOC1 AGL CAPN1 ANXA2 SNAP29 GYG1 CEP290 TUBB DYNLL1 DEGS1 PSAP FCGR2A C3AR1 DYNC1H1 GM2A PYCARD SPTAN1 RAB7A ARPC5 XRCC6 DSP XRCC5 DSG1 GLA PKP1 ACTR2 CDA IMPDH1 IMPDH2 PRSS3 GSN FRMPD3 GMFG ABCA13 PGLYRP1 PRSS2 NHLRC3 MCEMP1 ARMC8 RNASE3 GNS RNASE2 SCAMP1 UNC13D ATP8A1 FLG2 FPR1 A1BG FPR2 PLAC8 CRACR2A PRDX4 S100A11 GSDMD ATP11B FUCA1 ATP11A HMOX2 FUCA2 AZU1 MGST1 PA2G4 LYZ HRNR PIGR SERPINA3 SERPINA1 TCN1 SIGLEC9 MMP25 TIMP2 OLR1 SERPINB3 SERPINB1 AHSG PYGB NFAM1 TRPM2 TMC6 SERPINB6 PLEKHO2 SERPINB10 PYGL GRN SERPINB12 AGA CFP METTL7A ERP44 LRG1 PPIE YPEL5 SIGLEC5 GHDC TMEM179B RAB3D ATP8B4 HP EPX STK10 RAB44 LAMP1 GLIPR1 LAMP2 TOM1 TMEM173 KCMF1 IST1 OLFM4 ILF2 ALOX5 CLEC4C CLEC4D RAB31 RAB37 MANBA ADAM8 NME2 DSC1 S100A9 DNAJC3 ARL8A CAT S100A8 S100A7 AMPD3 RETN RAB5B BRI3 UBR4 ANO6 TRAPPC1 DEFA4 DEFA1 PTPRB PTPRC NIT2 FAM47E-STBD1 ITGAM ITGB2 LRMP ITGAL FCAR ITGAX RNASET2 DDOST PKM TMBIM1 BPI ACPP STOM CANT1 FGL2 CECR1 RAB24 CPPED1 RAB10 NFASC TSPAN14 MNDA FOLR3 CALML5 LGALS3 TBC1D10C GOLGA7 C6orf120 ALDH3B1 SLC11A1 KRT1 MIF CHIT1 SLPI TOLLIP CRISPLD2 DOCK2 C16orf62 TMEM63A SYNGR1 COMMD9 MAN2B1 VAT1 PTPRN2 STK11IP PRG2 B4GALT1 NBEAL2 PRG3 PPBP SLC2A3 CYSTM1 ORM1 FAF2 HBB TCIRG1 MAGT1 FRK ORM2 ACTR1B NAPRT CTSH QSOX1 CTSC CD33 CAP1 GUSB CD53 EEF1A1 FCER1G COMMD3 RAP2C EEF2 CEACAM3 CEACAM1 RAP2B HMGB1 CEACAM6 ATP6V0C CEACAM8 CD47 TTR DNASE1L1 CD63 CSTB C1orf35 CAND1 LILRA3 CST3 PGRMC1 CXCR1 CREG1 CXCR2 CD58 ATP6V1D LAIR1 GCA ATP6V0A1 HUWE1 LILRB2 LILRB3 RAB14 SVIP S100A12 VAPA QPCT CD68 LCN2 RAB9B FCN1 SRP14 MPO PLAU COTL1 SIRPA CR1 ENPP4 HMHA1 OSTF1 CD93 CD300A ATAD3B OSCAR DOK3 ADGRG3 C5AR1 CNN2 SDCBP DPP7 MGAM GGH CDK13 PNP DNAJC13 SELL TARM1 MS4A3 HLA-A DDX3X B2M TNFAIP6 CRISP3 AP1M1 CD59 CXCL1 ELANE SLC2A5 CD55 HEBP2 ADGRE5 ADGRE3 HGSNAT PSMD6 TICAM2 DYNLT1 MMP8 PSMD7 MMP9 CD14 CKAP4 SNAP25 CHI3L1 PSMD2 ARHGAP9 RAB3A LTF CLEC12A PSMD3 MVP MOSPD2 PSMD1 GDI2 ADAM10 DEFA1B TMEM30A CMTM6 PRKCD PDAP1 FGR GALNS PTX3 PSMA5 S100P RHOG PSMA2 RHOF P2RX1 PTPN6 DERA PSMD12 PSMD11 PSMD14 VNN1 VCL PSMD13 RAP1B ATG7 PSMB7 LAMTOR2 LAMTOR1 LAMTOR3 PSMB1 HSPA8 PSMC3 PSMC2 PTGES2 COPB1 CAB39 SURF4 NPC2 HVCN1 IDH1 PAFAH1B2 THE ACTIVATION OF ARYLSULFATASES%REACTOME DATABASE ID RELEASE 72%1663150 The activation of arylsulfatases SUMF2 SUMF1 ARSJ STS ARSK ARSH ARSI ARSA ARSF ARSG ARSD ARSE ARSB TRANSCRIPTIONAL REGULATION BY RUNX1%REACTOME%R-HSA-8878171.3 Transcriptional regulation by RUNX1 CSNK2A1 CSNK2A2 ITCH BMI1 RNF2 CSNK2B CTSV CBX8 PHC2 PHC1 CTSL CTSK RING1 CBX4 CBX2 PML TNRC6C PHC3 TNRC6A TNRC6B MYL9 IFNG GPAM CCNH HIST1H2AE HIST1H2AD SMARCD3 HIST3H2BB HIST1H2AC HIST1H2AB HIST1H2AJ HIST2H3A HIST1H2BF PRKCQ HIST1H2BE HIST1H2BH HIST1H2BG HIST2H3D HIST1H2BB HIST1H2BA HIST2H3C HIST1H2BD TJP1 HIST1H2BC OCLN H2AFB1 SOCS3 GP1BA HIST1H3J HIST1H3A HIST1H3F HIST1H3G HIST1H3H ACTL6A HIST1H3I RSPO3 HIST1H3B HIST1H3C HIST1H3D HIST1H3E H3F3B HIST1H4K PF4 HIST1H4L H3F3A H2BFS HIST1H4A CDK7 HIST1H4B HIST1H4H HIST1H4I HIST1H4J HIST1H4C MNAT1 HIST1H4D HIST1H4E HIST1H4F HIST2H2AA3 HIST2H2AA4 HIST2H2AC SIN3B H2AFJ SIN3A H2AFZ H2AFX THBS1 H2AFV SMARCB1 HIST2H2BE ABL1 KAT2B HIST4H4 SMARCC1 SMARCC2 HIST1H2BN HIST1H2BM HIST1H2BO HIST1H2BJ HDAC1 HIST1H2BI HIST1H2BL HIST1H2BK SETD1B SETD1A HIST2H4A HIST2H4B SMARCA2 SMARCA4 CBX6 ASH2L PRMT6 PBRM1 ACTL6B LGALS3 TNFRSF18 CCND1 ARID2 KMT2E KMT2D KMT2A KMT2C KMT2B ESR1 KCTD6 CREBBP DPY30 CR1 WDR5 MOV10 AGO3 AGO4 AGO1 AGO2 ARID1A ARID1B SMARCD1 TP73 SMARCD2 RBBP5 SMARCE1 PSMD8 MYB PSMD9 PSMD6 GATA3 SRC PSMD7 PSMD4 PSMD5 IL3 AXIN1 PSMD2 PRKCB PSMD3 PSMD1 YAF2 PTPN11 PSMA5 PSMA6 PRMT1 PSMA3 BLK PSMA4 RYBP ELF1 PSMA1 ITGA2B ELF2 CBFB PAX5 PSMA2 RUNX1 PSME3 CCND3 PSME4 CCND2 PSME1 CDK6 PSME2 UBA52 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 SPI1 PSMB10 CLDN5 PSMA8 ZFPM1 GATA2 GATA1 PSMB6 EP300 NFE2 NFATC2 PSMB7 HIPK2 CTLA4 TAL1 PSMB4 YAP1 TCF12 SERPINB13 PSMB5 PSMB2 PCGF5 CSF2 UBB PSMB3 LMO1 LMO2 FOXP3 UBC SOCS4 PSMB1 AUTS2 PSMF1 IL2 NR4A3 RPS27A TCF3 LDB1 IL2RA SHFM1 PSMB8 PSMB9 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 LIFR SIGNALING BY FGFR3 IN DISEASE%REACTOME DATABASE ID RELEASE 72%5655332 Signaling by FGFR3 in disease HRAS FRS2 FGF16 FGFR3 FGF18 NRAS GAB1 PIK3R1 PIK3CA FGF9 PLCG1 SOS1 FGF20 FGF1 FGF2 FGF23 FGF4 ERYTHROCYTES TAKE UP CARBON DIOXIDE AND RELEASE OXYGEN%REACTOME DATABASE ID RELEASE 72%1237044 Erythrocytes take up carbon dioxide and release oxygen CYB5R1 CYB5R4 CYB5RL AQP1 HBB RHAG SLC4A1 CA1 CA2 CA4 HBA2 HBA1 CYB5R2 CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE%REACTOME DATABASE ID RELEASE 72%442720 CREB1 phosphorylation through the activation of Adenylate Cyclase PRKX CREB1 PRKAR2B PRKAR2A PRKACG ADCY1 PRKACA PRKAR1B ADCY8 PRKACB PRKAR1A TRANSCRIPTIONAL ACTIVATION OF CELL CYCLE INHIBITOR P21%REACTOME DATABASE ID RELEASE 72%69895 Transcriptional activation of cell cycle inhibitor p21 PCBP4 ZNF385A TP53 CDKN1A CHL1 INTERACTIONS%REACTOME DATABASE ID RELEASE 72%447041 CHL1 interactions ITGB1 ITGA1 HSPA8 NRP1 CNTN6 CHL1 ITGA10 ANK1 ITGA2 SORAFENIB-RESISTANT PDGFR MUTANTS%REACTOME DATABASE ID RELEASE 72%9674404 Sorafenib-resistant PDGFR mutants PDGFRA CHEMOKINE RECEPTORS BIND CHEMOKINES%REACTOME%R-HSA-380108.3 Chemokine receptors bind chemokines CXCL6 CXCL9 CXCL3 CXCL13 CXCL2 CX3CL1 CXCL5 CXCL8 CXCL16 CCRL2 CCR9 CCR8 CCR7 CCR6 CCR4 CCR3 CCR2 XCL2 XCL1 CCR5 CX3CR1 CCL13 CXCR4 CCL11 CCL3L1 CCL3L3 CXCR5 CXCR6 CCL7 CCL5 CXCR3 CCL4 CCL3 CCL2 CCL1 CCL19 CCL17 CCL16 CCR10 CCL25 CCR1 CCL22 XCR1 CCL21 CCL20 CXCL10 CXCL11 ACKR4 ACKR3 PPBP ACKR2 CCL28 CCL27 PF4 CXCR1 CXCR2 CXCL1 CXCL12 EPHA-MEDIATED GROWTH CONE COLLAPSE%REACTOME%R-HSA-3928663.3 EPHA-mediated growth cone collapse LYN YES1 MYL12B MYH9 RHOA MYH11 ROCK1 ROCK2 MYH14 MYH10 NGEF MYL6 MYL9 FYN LXRS REGULATE GENE EXPRESSION LINKED TO CHOLESTEROL TRANSPORT AND EFFLUX%REACTOME%R-HSA-9029569.1 LXRs regulate gene expression linked to cholesterol transport and efflux TNRC6A TNRC6B TBL1X APOE TBL1XR1 KDM4A APOC2 NCOA1 NCOR2 HDAC3 NCOR1 ABCA1 ABCG1 CETP EP300 MOV10 AGO3 AGO4 RXRB AGO1 KDM1A RXRA AGO2 KDM1B APOC4 KDM3A APOC1 NR1H2 APOD TNRC6C GPS2 ABCG8 ABCG5 NR1H3 ARL4C EEPD1 GABA B RECEPTOR ACTIVATION%REACTOME%R-HSA-977444.2 GABA B receptor activation GNG11 GNG13 KCNJ3 KCNJ5 GNB2 KCNJ6 KCNJ10 GNB1 GNB4 KCNJ2 KCNJ9 KCNJ15 GNB3 KCNJ4 KCNJ16 KCNJ12 GNB5 GNAL GNGT1 GNGT2 ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 GABBR2 GABBR1 GNAI3 GNAT3 GNAI1 GNAI2 GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 GNG10 ADCY9 GNG12 ANTIGEN PROCESSING-CROSS PRESENTATION%REACTOME%R-HSA-1236975.1 Antigen processing-Cross presentation PDIA3 CALR SNAP23 TIRAP VAMP8 TLR1 CTSV TLR6 TLR2 CTSS CTSL STX4 ITGB5 IKBKB LNPEP SEC61A2 SEC61A1 SEC61G CHUK SEC61B VAMP3 CD36 MYD88 NCF1 NCF2 NCF4 HLA-A B2M FCGR1A PSMD8 PSMD9 PSMD6 LY96 PSMD7 ITGAV PSMD4 CD14 PSMD5 TLR4 PSMD2 PSMD3 PSMD1 CYBB CYBA FCGR1B PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 UBA52 PSMD10 PSMB11 PSMD12 MRC2 MRC1 PSMD11 CD207 PSMD14 IKBKG PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 UBB PSMB3 UBC PSMB1 PSMF1 RPS27A SHFM1 PSMB8 HLA-B PSMB9 TAP2 PSMC5 HLA-C PSMC6 TAP1 PSMC3 HLA-F PSMC4 HLA-G PSMC1 HLA-E PSMC2 TAPBP BTK SEC22B FRS2-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 72%170968 Frs2-mediated activation RAPGEF1 MAP2K1 YWHAB MAP2K2 BRAF FRS2 RAP1A CRKL MAPK1 NGF MAPK3 BETA DEFENSINS%REACTOME DATABASE ID RELEASE 72%1461957 Beta defensins DEFB107B DEFB104B DEFB106B DEFB104A DEFB119 DEFB118 DEFB116 DEFB115 DEFB136 DEFB114 DEFB135 DEFB113 CCR6 DEFB134 DEFB112 DEFB133 CCR2 DEFB132 DEFB108B DEFB110 DEFB131 DEFB106A DEFB4A DEFB4B TLR1 TLR2 DEFB103A DEFB103B DEFB105A DEFB105B DEFB129 DEFB128 DEFB127 DEFB126 DEFB125 DEFB124 DEFB1 DEFB123 DEFB107A DEFB121 DEFECTIVE SLC17A5 CAUSES SALLA DISEASE (SD) AND ISSD%REACTOME%R-HSA-5619035.1 Defective SLC17A5 causes Salla disease (SD) and ISSD SLC17A5 KILLING MECHANISMS%REACTOME%R-HSA-9664420.1 Killing mechanisms NOXO1 DVL2 CYBA MAPK8 FZD7 DVL1 DVL3 NOX1 JUN RAC1 NOXA1 WNT5A ESSENTIAL PENTOSURIA%REACTOME DATABASE ID RELEASE 72%5662853 Essential pentosuria DCXR DOWNREGULATION OF ERBB2:ERBB3 SIGNALING%REACTOME%R-HSA-1358803.1 Downregulation of ERBB2:ERBB3 signaling UBC AKT1 NRG1 RPS27A UBA52 AKT2 NRG2 AKT3 RNF41 ERBB2 USP8 UBB TCR SIGNALING%REACTOME DATABASE ID RELEASE 72%202403 TCR signaling PTPRC CUL1 PLCG2 RELA CD4 LCK IKBKB CHUK RIPK2 UBE2V1 CD3G NFKB1 FBXW11 HLA-DPA1 PIK3CB PSMD8 PSMD9 PSMD6 GRAP2 PSMD7 HLA-DQB2 PSMD4 LCP2 HLA-DQB1 PSMD5 NCK1 CSK PSMD2 PSMD3 PAG1 PDPK1 PSMD1 HLA-DQA2 HLA-DQA1 PSMA5 PSMA6 HLA-DRB5 PSMA3 PSMA4 HLA-DRB4 PSMA1 PSMA2 HLA-DPB1 PSME3 HLA-DRA PSME4 PSME1 WAS PSME2 HLA-DRB3 HLA-DRB1 UBA52 PIK3R2 PSMD10 PSMB11 PAK1 PSMD12 PSMD11 PSMD14 NFKBIA IKBKG PSMD13 PAK3 PSMA7 PSMB10 PAK2 PSMA8 PRKCQ PSMB6 PSMB7 PSMB4 UBE2D1 PSMB5 PSMB2 UBB PSMB3 CDC34 CARD11 CD101 UBC BCL10 PSMB1 PSMF1 VASP TRAV19 LAT RPS27A ITK PTPN22 CD3E SHFM1 CD3D ENAH ZAP70 PSMB8 UBE2D2 EVL PSMB9 MALT1 PSMC5 FYB PSMC6 TRAT1 PSMC3 PSMC4 PSMC1 PSMC2 UBE2N INPP5D PIK3R1 PIK3CA PLCG1 BTRC SKP1 PTPRJ TRAF6 TAB2 PTEN MAP3K7 GLUCURONIDATION%REACTOME%R-HSA-156588.3 Glucuronidation SLC35D1 UGT1A5 UGT2A3 UGT1A4 UGT2A2 UGT1A3 UGT2A1 UGT1A9 UGT1A8 UGT2B10 UGT1A7 UGT1A6 UGT2B11 UGT2B4 UGT2B15 UGT2B17 ABHD10 UGT2B7 UGP2 UGT2B28 UGT1A10 UGDH UGT1A1 UGT3A2 UGT3A1 PHASE 3 - RAPID REPOLARISATION%REACTOME DATABASE ID RELEASE 72%5576890 Phase 3 - rapid repolarisation KCNE4 KCNE5 AKAP9 KCNH2 KCNQ1 KCNE1 KCNE2 KCNE3 METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS%REACTOME DATABASE ID RELEASE 72%2022377 Metabolism of Angiotensinogen to Angiotensins CPB1 ACE ANPEP CMA1 AGT CTSG CTSD CPA3 MME ATP6AP2 C9orf3 GZMH ACE2 REN CTSZ CPB2 ENPEP CES1 CLATHRIN-MEDIATED ENDOCYTOSIS%REACTOME DATABASE ID RELEASE 72%8856828 Clathrin-mediated endocytosis HIP1 STON1 STON2 SLC2A8 SGIP1 DNM1 TACR1 EPN2 DNM3 CTTN VAMP4 FCHO1 APOB FCHO2 REPS2 UBQLN1 REPS1 UBQLN2 SNX18 NECAP2 SYT11 OCRL TFRC ARRB1 CD4 SYNJ2 SYNJ1 SH3GL2 PIK3C2A GAK VAMP8 PIP5K1C VAMP7 DNAJC6 RAB5C TGOLN2 SNX9 ADRB2 HIP1R M6PR AVP IGF2R NEDD8 SLC18A3 VAMP3 NECAP1 WASL PICALM CD3G TF FZD4 AVPR2 BTC EPGN TGFA AREG HBEGF WNT5A EREG CLTC CLTB CLTA AP2A1 AP2B1 AP2A2 AP2S1 AP2M1 SH3KBP1 EPS15 SYT1 SH3GL1 EPS15L1 EPN1 SYT2 SYT9 ARPC1A STAM VAMP2 ARRB2 ADRBK2 COPS7B UBA52 COPS7A HGS RAB5A SH3GL3 STAM2 ARPC4 ARPC5 ARPC2 ARPC3 TRIP10 ACTR3 ACTR2 ADRBK1 DVL2 ARF6 UBB DNM2 UBC RPS27A HSPA8 CD3D GPS1 EGF CBL EGFR LDLRAP1 ITSN2 ITSN1 SCARB2 CHRM2 FNBP1L AGFG1 FNBP1 LRP2 GAPVD1 BIN1 AGTR1 COPS4 LDLR AMPH COPS3 CFTR COPS6 ARFGAP1 CLTCL1 COPS5 PACSIN2 PACSIN3 COPS2 KIAA0319 PACSIN1 RAB5B TOR1A COPS8 TOR1B SYT8 SNAP91 DAB2 AAK1 IL7R SYNTHESIS AND PROCESSING OF ENV AND VPU%REACTOME DATABASE ID RELEASE 72%171286 Synthesis and processing of ENV and VPU FURIN SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN%REACTOME DATABASE ID RELEASE 72%422085 Synthesis, secretion, and deacylation of Ghrelin PCSK1 PLA2G7 UCN SEC11A SEC11C INS LEP ACHE MBOAT4 IGF1 KLF4 SPCS3 BCHE SPCS2 SPCS1 GH1 CRHR2 GCG PCP CE PATHWAY%REACTOME DATABASE ID RELEASE 72%4086400 PCP CE pathway PSMD3 PSMD1 PRKCA RAC2 PSMA5 RAC3 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 ARRB2 PRKCG PSME3 PSME4 PSME1 PSME2 UBA52 PSMD10 WNT5B PSMB11 DVL1 DAAM1 PSMD12 PFN1 DVL3 PSMD11 WNT11 PSMD14 PSMD13 PSMA7 PSMB10 SCRIB PSMA8 PRICKLE1 DVL2 PSMB6 FZD1 FZD3 PSMB7 SMURF2 FZD7 PSMB4 VANGL2 PSMB5 PSMB2 UBB PSMB3 UBC PSMB1 PSMF1 RPS27A SHFM1 PSMB8 PSMB9 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 WNT1 WNT4 FZD4 FZD6 FZD8 SMURF1 RHOA FZD2 FZD5 WNT5A PARD6A CLTC CLTB CLTA AP2A1 AP2B1 AP2A2 AP2S1 ROR1 PSMD8 ROR2 PSMD9 AP2M1 PSMD6 PSMD7 PSMD4 RAC1 PSMD5 PSMD2 PRKCB EPHRIN SIGNALING%REACTOME%R-HSA-3928664.2 Ephrin signaling PAK2 EFNB2 EFNB1 MYL12A EFNB3 EPHB2 EPHB1 GIT1 SDCBP EPHB4 ARHGEF7 EPHB3 PAK1 NCK2 FYN RAC1 PAK3 PKA-MEDIATED PHOSPHORYLATION OF KEY METABOLIC FACTORS%REACTOME%R-HSA-163358.2 PKA-mediated phosphorylation of key metabolic factors MLXIPL PFKFB1 PRKACG PRKACA PRKACB TRANSCRIPTIONAL ACTIVATION OF P53 RESPONSIVE GENES%REACTOME%R-HSA-69560.2 Transcriptional activation of p53 responsive genes PCBP4 ZNF385A TP53 CDKN1A FORMATION OF INCISION COMPLEX IN GG-NER%REACTOME%R-HSA-5696395.1 Formation of Incision Complex in GG-NER SUMO2 RPA1 CDK7 RPA2 RNF111 RPA3 USP45 MNAT1 RAD23A UBE2N RAD23B DDB2 CCNH XPA XPC PIAS3 CETN2 GTF2H1 UBA52 GTF2H2 GTF2H3 CHD1L GTF2H4 PIAS1 GTF2H5 ERCC3 UBE2V2 ERCC2 CUL4A ERCC4 ERCC1 UBE2I UBB ERCC5 UBC PARP1 CUL4B PARP2 RPS27A DDB1 RBX1 SUMO1 SUMO3 VARIANT SLC6A20 CONTRIBUTES TOWARDS HYPERGLYCINURIA (HG) AND IMINOGLYCINURIA (IG)%REACTOME DATABASE ID RELEASE 72%5660686 Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG) SLC6A20 DEFECTIVE MAT1A CAUSES METHIONINE ADENOSYLTRANSFERASE DEFICIENCY (MATD)%REACTOME%R-HSA-5579024.1 Defective MAT1A causes Methionine adenosyltransferase deficiency (MATD) MAT1A CELLULAR RESPONSE TO HEAT STRESS%REACTOME%R-HSA-3371556.1 Cellular response to heat stress BAG4 CAMK2D HSPA4 RPA1 CAMK2A HSPA6 RPA2 HSPA2 RPA3 HSPB8 CAMK2G HSPA9 NUP107 NUP188 NUP62 NDC1 NUP214 SEC13 NUP133 NUP210 EP300 MTOR NUP93 HSPA4L NUP50 HSPH1 NUP54 ST13 MAPKAPK2 CRYAB HSPA14 HSPA13 HSPA8 HSPA5 C11orf73 POM121 EEF1A1 NUP205 MAPK1 AAAS DNAJB1 MAPK3 NUP160 HSPA1L NUP85 TPR NUP88 NUP43 BAG5 HSP90AB1 BAG2 BAG3 RAE1 BAG1 RANBP2 PTGES3 GSK3B NUP155 HSBP1 HSF1 DNAJC2 NUP153 DNAJC7 HSP90AA1 DNAJB6 NUP35 NUPL2 CREBBP NUP37 AKT1S1 CCAR2 SIRT1 HDAC6 ATM HSPA12A ATR HSPA12B YWHAE VCP MLST8 FKBP4 RPS19BP1 RPTOR CAMK2B TRIF-MEDIATED PROGRAMMED CELL DEATH%REACTOME%R-HSA-2562578.1 TRIF-mediated programmed cell death RIPK1 FADD TICAM2 RIPK3 LY96 TICAM1 CD14 TLR4 CASP8 E2F MEDIATED REGULATION OF DNA REPLICATION%REACTOME DATABASE ID RELEASE 72%113510 E2F mediated regulation of DNA replication PPP2CA ORC4 PPP2CB ORC6 ORC1 ORC3 ORC2 E2F1 POLA1 POLA2 MCM8 CCNB1 CDK1 TFDP1 PRIM2 TFDP2 PPP2R1B RB1 PRIM1 PPP2R1A PPP2R3B ORC5 PLASMALOGEN BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 72%75896 Plasmalogen biosynthesis AGPS DHRS7B GNPAT THE NLRP3 INFLAMMASOME%REACTOME%R-HSA-844456.2 The NLRP3 inflammasome CASP1 SUGT1 HSP90AB1 P2RX7 TXNIP MEFV TXN NFKB1 NFKB2 PYCARD NLRP3 APP PANX1 RELA PSTPIP1 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER%REACTOME DATABASE ID RELEASE 72%2173793 Transcriptional activity of SMAD2 SMAD3:SMAD4 heterotrimer RNF111 MEN1 SNW1 NEDD4L CCNC SMAD2 SMAD3 UBA52 TFDP1 RBL1 SMAD7 TFDP2 WWTR1 E2F5 NCOR2 CDK9 PPM1A NCOR1 JUNB SMAD4 SMURF2 E2F4 UBE2D1 UBB CCNK UBC PARP1 CCNT2 SERPINE1 CCNT1 SKIL RPS27A TGIF1 TGIF2 HDAC1 USP9X SP1 ATP1B4 SKI TRIM33 MYC UBE2D3 CDKN2B CDK8 MANIPULATION OF HOST ENERGY METABOLISM%REACTOME%R-HSA-9636667.2 Manipulation of host energy metabolism ENO1 PGK1 FCGR3A-MEDIATED IL10 SYNTHESIS%REACTOME%R-HSA-9664323.1 FCGR3A-mediated IL10 synthesis IGKV3-11 PRKAR2B LYN PRKAR2A YES1 FGR PLCG2 CD3G ITPR1 FCGR3A ITPR2 IGKV2-28 ITPR3 IL10 PLCG1 ADCY4 SYK ADCY3 PRKACG ADCY2 ADCY1 PRKACA ADCY8 FYN PRKACB ADCY7 IGHG4 IGKV3D-20 ADCY6 ADCY5 IGHG1 IGHG2 IGKV1-12 HCK AHCYL1 IGKV2D-28 IGKV4-1 PRKX CREB1 IGKV2D-30 FCGR1A IGKV5-2 ADCY9 FCGR2A PRKAR1B PRKAR1A FORMATION OF HIV ELONGATION COMPLEX IN THE ABSENCE OF HIV TAT%REACTOME DATABASE ID RELEASE 72%167152 Formation of HIV elongation complex in the absence of HIV Tat GTF2F1 GTF2F2 CDK7 POLR2A POLR2B TCEB3C POLR2C POLR2D TCEB3B POLR2G POLR2E NELFB MNAT1 POLR2F NELFA NELFCD POLR2H POLR2I POLR2J NELFE POLR2K TCEB3CL2 CCNH POLR2L TCEB3 GTF2H1 TCEB2 GTF2H2 TCEB1 GTF2H3 TCEB3CL GTF2H4 GTF2H5 ERCC3 ERCC2 CDK9 TCEA1 CCNK CCNT2 ELL CCNT1 SSRP1 CTDP1 NCBP1 SUPT16H NCBP2 SUPT4H1 SUPT5H FGFR3 MUTANT RECEPTOR ACTIVATION%REACTOME%R-HSA-2033514.1 FGFR3 mutant receptor activation FGF9 FGF20 FGF16 FGF1 FGFR3 FGF2 FGF18 FGF23 FGF4 MYOGENESIS%REACTOME DATABASE ID RELEASE 72%525793 Myogenesis MAPK14 MAPK11 NTN3 CDH4 CDH2 BNIP2 CTNNA2 NEO1 CDON SPAG9 MYOG MEF2B MYOD1 MYF6 MAP2K6 TCF4 CDC42 CDH15 MYF5 CTNNA1 ABL1 MEF2A MEF2C MAPK12 TCF12 CTNNB1 TCF3 MEF2D RHO GTPASES ACTIVATE RHOTEKIN AND RHOPHILINS%REACTOME DATABASE ID RELEASE 72%5666185 RHO GTPases Activate Rhotekin and Rhophilins RHPN2 ROPN1 RHOB LIN7B RHOA RTKN RHPN1 TAX1BP3 RHOC MAP KINASE ACTIVATION%REACTOME DATABASE ID RELEASE 72%450294 MAP kinase activation CUL1 MAP2K1 MAPKAPK3 UBA52 MAPK8 PPP2R1B ATF1 PPP2R1A ATF2 IKBKG ELK1 RPS6KA3 RPS6KA5 RPS6KA2 RPS6KA1 DUSP4 PPP2R5D MEF2A MEF2C DUSP3 FOS VRK3 UBB DUSP6 DUSP7 UBC CREB1 MAPKAPK2 RPS27A MAPK7 MAPK1 MAPK3 PPP2CA PPP2CB IKBKB MAPK14 MAP3K8 MAP2K3 CHUK MAPK11 MAP2K4 RIPK2 UBE2N UBE2V1 NOD1 NFKB1 NOD2 MAPK9 IRAK1 MAP2K6 MAP2K7 MAPK10 TNIP2 JUN FBXW11 BTRC SKP1 IRAK2 TRAF6 TAB3 TAB2 TAB1 MAP3K7 RHO GTPASE EFFECTORS%REACTOME%R-HSA-195258.3 RHO GTPase Effectors CDH1 IQGAP2 IQGAP3 MEN1 YWHAG YWHAH PPP2R5C ERCC6L ZWILCH DLG4 BUB1B CASC5 CDC20 KNTC1 DYNC1LI1 BIRC5 DYNC1LI2 CLIP1 ZW10 MAD1L1 CDCA8 PMF1 SKA1 AURKB SKA2 DSN1 RCC2 NDC80 ZWINT KIF18A SGOL2 SGOL1 NUF2 SPDL1 NDEL1 NUDC MYH14 MYH10 DYNLL2 MKL1 KIF2A INCENP KIF2C KIF2B ITGB3BP MIS12 CENPA NSL1 CENPC BUB3 BUB1 DYNC1I1 CLASP2 CENPT CENPU MYL12B CENPE MYLK CENPF CENPH CENPI TAOK1 CENPK MYH11 CENPL CENPM IQGAP1 CENPN B9D2 CENPO CENPP CENPQ SPC24 MAD2L1 SPC25 PPP1CB MYL6 MYL9 PPP1R12A MYH9 DYNLL1 CKAP5 MAPRE1 PAFAH1B1 DYNC1I2 WIPF1 WIPF2 CLASP1 WIPF3 DYNC1H1 NOX1 ARPC1B NDE1 ARPC1A WAS NOXO1 ACTG1 ACTB NCKIPSD HIST1H2AE DVL1 HIST1H2AD HIST3H2BB DVL3 HIST1H2AC ARPC4 HIST1H2AB ARPC5 ARPC2 HIST1H2AJ ARPC3 NOXA1 HIST2H3A ACTR3 HIST1H2BF ACTR2 HIST1H2BE AR HIST1H2BH HIST1H2BG HIST2H3D HIST1H2BB PLK1 HIST1H2BA HIST2H3C HIST1H2BD HIST1H2BC H2AFB1 HIST1H3J HIST1H3A HIST1H3F HIST1H3G HIST1H3H HIST1H3I HIST1H3B HIST1H3C HIST1H3D HIST1H3E H3F3B HIST1H4K EVL HIST1H4L H3F3A H2BFS HIST1H4A HIST1H4B HIST1H4H HIST1H4I HIST1H4J HIST1H4C APITD1 HIST1H4D HIST1H4E HIST1H4F HIST2H2AA3 HIST2H2AA4 HIST2H2AC H2AFJ PIK3C3 H2AFZ H2AFX H2AFV HIST2H2BE ABL1 PRKCZ RHOA HIST4H4 HIST1H2BN HIST1H2BM CFTR HIST1H2BO S100A9 HIST1H2BJ S100A8 HIST1H2BI HIST1H2BL HIST1H2BK HIST2H4A HIST2H4B PPP1CC CTTN NUP107 PPP2R1B PPP2R1A DAAM1 PFN1 SEC13 NUP133 PIK3R4 PPP2R5D KDM1A KIF5B KIF5A DIAPH1 NUP160 PPP2CA PPP2CB NUP85 NUP43 RANBP2 WASL SFN RTKN NCOA2 RHPN1 TAX1BP3 NUP37 RHPN2 ROPN1 CYFIP2 CYFIP1 NCKAP1 NCF1 NCF2 NCF4 CDKN1B BRK1 YWHAB KDM4C PFN2 KLK3 XPO1 KLK2 SCAI RAC1 NOX3 NCK1 KIF14 PRKCB CIT PPP2R5E PKN3 PDPK1 KTN1 PKN2 CYBB GOPC CYBA PKN1 PPP2R5B PRKCD CFL1 LIN7B PPP2R5A PRKCA DIAPH3 NF2 YWHAZ RAC2 PPP1R12B PPP1R14A RHOG LIMK2 LIMK1 FMNL3 ROCK1 FMNL1 ROCK2 FMNL2 RHOC PRC1 RHOD RHOB CDC42 PAK1 RHOQ CTNNA1 NCKAP1L RPS27 WASF1 PAK3 WASF2 PAK2 WASF3 DVL2 BAIAP2 PTK2 ABI2 ABI1 CTNNB1 SRF MAPK1 MAPK3 FLNA CDC25C MAPK14 MAPK11 AHCTF1 RANGAP1 KLC1 KLC4 KLC3 KLC2 PIN1 ITGB1 YWHAE BTK YWHAQ DEFECTIVE MISMATCH REPAIR ASSOCIATED WITH PMS2%REACTOME DATABASE ID RELEASE 72%5632987 Defective Mismatch Repair Associated With PMS2 MLH1 PMS2 DISEASES ASSOCIATED WITH SURFACTANT METABOLISM%REACTOME DATABASE ID RELEASE 72%5687613 Diseases associated with surfactant metabolism SLC34A2 ABCA3 SFTA3 SFTPB SFTPA2 SFTPC SFTPD CSF2RB SFTPA1 CSF2RA HIGHLY CALCIUM PERMEABLE NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME DATABASE ID RELEASE 72%629597 Highly calcium permeable nicotinic acetylcholine receptors CHRNA1 CHRNB2 CHRNB4 CHRNA3 CHRNB3 CHRNA2 CHRNA5 CHRNA4 CHRNA6 ACTIVATION OF RRNA EXPRESSION BY ERCC6 (CSB) AND EHMT2 (G9A)%REACTOME DATABASE ID RELEASE 72%427389 Activation of rRNA Expression by ERCC6 (CSB) and EHMT2 (G9a) RBBP4 RBBP7 MTA2 MTA3 EHMT2 MBD3 TTF1 HIST1H2AE HIST1H2AD HIST3H2BB GATAD2B HIST1H2AC HIST1H2AB GATAD2A CHD4 HIST1H2AJ ERCC6 HIST2H3A HIST1H2BF HIST1H2BE HIST1H2BH HIST1H2BG HIST2H3D HIST1H2BB HIST1H2BA HIST2H3C HIST1H2BD HIST1H2BC H2AFB1 HIST1H3J HIST1H3A HIST1H3F HIST1H3G HIST1H3H HIST1H3I HIST1H3B HIST1H3C HIST1H3D HIST1H3E H3F3B HIST1H4K CBX3 HIST1H4L H3F3A H2BFS HIST1H4A HIST1H4B HIST1H4H HIST1H4I HIST1H4J HIST1H4C HIST1H4D HIST1H4E HIST1H4F HIST2H2AA3 HIST2H2AA4 CHD3 HIST2H2AC H2AFJ H2AFZ H2AFX H2AFV HIST2H2BE HIST4H4 HIST1H2BN HIST1H2BM HDAC2 HIST1H2BO HIST1H2BJ HDAC1 HIST1H2BI HIST1H2BL HIST1H2BK HIST2H4A HIST2H4B MTA1 IRS-MEDIATED SIGNALLING%REACTOME%R-HSA-112399.3 IRS-mediated signalling PDPK1 FRS2 PTPN11 FGF16 TRIB3 FGF7 FGF18 TLR9 GAB1 PIK3R1 PIK3R2 FGF6 PIK3CA FGF9 SOS1 FGF20 FGF1 FGF2 FGF23 FGF3 FGF22 PIK3C3 FGF10 FGF4 HRAS PIK3R4 KLB IRS1 FLT3 NRAS PDE3B IRS2 THEM4 FLT3LG GAB2 FGF19 PIK3CB FGFR4 AKT2 DEFECTIVE CP CAUSES ACERULOPLASMINEMIA (ACERULOP)%REACTOME%R-HSA-5619060.1 Defective CP causes aceruloplasminemia (ACERULOP) SLC40A1 CP DEFECTIVE B4GALT1 CAUSES B4GALT1-CDG (CDG-2D)%REACTOME%R-HSA-4793953.1 Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) B4GALT1 DEFECTIVE GALT CAN CAUSE GALACTOSEMIA%REACTOME%R-HSA-5609978.2 Defective GALT can cause Galactosemia GALT SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP)%REACTOME%R-HSA-400511.2 Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) GIP GPR119 PCSK1 DPP4 SEC11A SEC11C FFAR1 PAX6 GATA4 ISL1 SPCS3 SPCS2 SPCS1 REGULATION OF TP53 DEGRADATION%REACTOME DATABASE ID RELEASE 72%6804757 Regulation of TP53 Degradation PPP2CA PDPK1 USP2 PPP2CB AKT1 TP53 MAPKAP1 PPP2R5C CCNA2 CCNA1 UBA52 PPP2R1B PPP2R1A RICTOR RNF34 CDKN2A MTOR PRR5 RFFL CCNG1 ATM UBB CDK2 MDM2 UBC CDK1 MDM4 RPS27A SGK1 PHF20 AKT2 AKT3 CHEK2 MLST8 USP7 DAXX LXRS REGULATE GENE EXPRESSION LINKED TO GLUCONEOGENESIS%REACTOME%R-HSA-9632974.1 LXRs regulate gene expression linked to gluconeogenesis RXRB RXRA PCK1 NRIP1 NR1H3 COSTIMULATION BY THE CD28 FAMILY%REACTOME%R-HSA-388841.2 Costimulation by the CD28 family PDPK1 AKT1 PPP2R5B VAV1 PPP2R5A HLA-DQA2 HLA-DQA1 PTPN11 TRIB3 HLA-DRB5 TNFRSF14 HLA-DRB4 HLA-DPB1 PPP2R5C MAPKAP1 HLA-DRA PTPN6 HLA-DRB3 HLA-DRB1 PIK3R2 ICOSLG CDC42 PPP2R1B PDCD1LG2 PAK1 MAP3K14 PPP2R1A CD274 BTLA RICTOR PDCD1 FYN PAK3 PAK2 CD4 PPP2R5D MTOR CTLA4 PIK3R3 THEM4 TRAV19 CD3E CD3D CD86 LCK CD80 PPP2CA PPP2CB CD28 LYN MAP3K8 YES1 CD3G PIK3R1 PIK3CA PRR5 HLA-DPA1 AKT2 AKT3 MLST8 GRAP2 HLA-DQB2 RAC1 HLA-DQB1 CSK PPP2R5E REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION%REACTOME%R-HSA-211733.1 Regulation of activated PAK-2p34 by proteasome mediated degradation PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 UBA52 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PAK2 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 UBB PSMB3 UBC PSMB1 PSMF1 RPS27A SHFM1 PSMB8 PSMB9 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 REGULATION OF LIPID METABOLISM BY PPARALPHA%REACTOME DATABASE ID RELEASE 72%400206 Regulation of lipid metabolism by PPARalpha ARNTL TBL1X ARNT2 THRAP3 CDK19 MED13L CCNC TBL1XR1 CYP1A1 FAM120B CLOCK PEX11A SREBF2 HMGCS2 HMGCS1 TXNRD1 APOA2 APOA1 GPS2 APOA5 CARM1 MED19 MED16 MED15 MED18 MED17 MED12 RGL1 MED11 MED14 ABCB4 MED13 UGT1A9 AGT MED10 AHR MED27 CD36 MED26 MED29 NCOA1 MED28 MED23 MED22 NCOA2 PPARGC1A CREBBP MED25 NCOA6 MED24 PPARGC1B NCOA3 MED21 ABCA1 MED20 RXRB PPARG RXRA PPARA ESRRA CPT1A TIAM2 CDK8 CYP4A11 SLC27A1 TRIB3 FADS1 TGS1 HELZ2 SMARCD3 FABP1 NRF1 EP300 NPAS2 MED30 RORA MED31 CHD9 ACADM CPT2 ACSL1 SP1 CYP7A1 ALAS1 NFYA FDFT1 NR1D1 FHL2 NFYB NFYC GRHL1 ME1 ARNT TNFRSF21 SIN3A NCOR2 NCOR1 HDAC3 MTF1 AHRR PLIN2 ANGPTL4 GLIPR1 SULT2A1 ANKRD1 MED1 MED8 NR1H2 MED9 MED4 MED6 NR1H4 MED7 G0S2 NR1H3 NEGATIVE REGULATION OF FGFR2 SIGNALING%REACTOME%R-HSA-5654727.1 Negative regulation of FGFR2 signaling PPP2CA PPP2CB BRAF FRS2 PTPN11 SPRY2 FGF16 FGF7 FGF18 CBL UBA52 FGF6 FGF9 PPP2R1A FGF20 FGF1 FGF2 FGF23 FGF3 MKNK1 FGF22 FGF10 FGF4 UBB UBC RPS27A MAPK1 MAPK3 NUCLEOTIDE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 72%5696398 Nucleotide Excision Repair LIG1 POLK RPA1 POLE RPA2 POLD3 RFC1 POLD4 ACTR5 RPA3 USP45 POLD1 POLR2E RAD23A POLD2 POLR2F RFC5 ACTR8 POLR2H RFC3 RFC4 RAD23B RFC2 POLR2K POLR2L TFPT GTF2H1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 ERCC3 ERCC2 ERCC6 CUL4A POLE4 ERCC4 ERCC1 POLE2 POLE3 ERCC8 ERCC5 CUL4B POLR2A POLR2B POLR2C POLR2D POLR2G POLR2I POLR2J CETN2 UBE2I ELL SUMO1 SUMO3 SUMO2 NFRKB RNF111 AQR DDB2 ZNF830 CCNH XPA COPS7B XPC UBA52 COPS7A ACTB XRCC1 INO80 EP300 TCEA1 UBB PRPF19 UBC PARP1 PARP2 ACTL6A RPS27A DDB1 GPS1 USP7 CDK7 MCRS1 XAB2 MNAT1 UBE2N YY1 RUVBL1 HMGN1 PIAS3 LIG3 CHD1L PIAS1 UBE2V2 PPIE INO80C INO80B INO80E INO80D COPS4 COPS3 COPS6 COPS5 COPS2 UVSSA RBX1 COPS8 ISY1 PCNA ELECTRON TRANSPORT FROM NADPH TO FERREDOXIN%REACTOME%R-HSA-2395516.1 Electron transport from NADPH to Ferredoxin FDXR FDX1 FDX1L HDMS DEMETHYLATE HISTONES%REACTOME%R-HSA-3214842.3 HDMs demethylate histones PHF2 PHF8 KDM4A KDM4B HIST2H3A HIST2H3D KDM1A HIST2H3C KDM1B HIST1H3J HIST1H3A HIST1H3F HIST1H3G HIST1H3H HIST1H3I HIST1H3B HIST1H3C KDM2A HIST1H3D HIST1H3E KDM2B HIST1H4K ARID5B HIST1H4L HIST1H4A HIST1H4B HIST1H4H HIST1H4I HIST1H4J HIST1H4C HIST1H4D HIST1H4E HIST1H4F KDM5A KDM5B KDM5C KDM5D UTY KDM6A KDM6B HIST4H4 KDM7A KDM3A KDM3B JMJD6 KDM4C KDM4D HIST2H4A HIST2H4B MINA PHAGOCYTE CELL DEATH CAUSED BY CYTOSOLIC MTB%REACTOME%R-HSA-9637698.1 Phagocyte cell death caused by cytosolic Mtb ABC-FAMILY PROTEINS MEDIATED TRANSPORT%REACTOME%R-HSA-382556.4 ABC-family proteins mediated transport OS9 RNF185 APOA1 ABCG8 ABCG5 ABCD1 ABCC3 ABCC1 ABCC2 ABCC5 ABCB1 ABCB7 ABCB4 ABCA3 PSMD8 PSMD9 PSMD6 ABCC9 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 UBA52 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 KCNJ11 EIF2S2 PSMB10 EIF2S1 PSMA8 EIF2S3 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 UBB PSMB3 UBC PSMB1 PSMF1 RPS27A SHFM1 ABCA12 ABCA10 PSMB8 ABCG4 PSMB9 ABCB6 PSMC5 ABCB5 PSMC6 ABCB8 PSMC3 ABCB9 PSMC4 ABCA2 PSMC1 ABCA5 PSMC2 ABCA4 ERLIN1 ABCA9 ABCA7 ERLIN2 ABCA8 ABCD2 ABCD3 ABCC10 ABCC11 ABCC4 ABCC6 PEX3 DERL3 ERLEC1 ABCF1 PEX19 ABCB10 ABCG1 CFTR VCP SEL1L ABCA6 DERL1 DERL2 RNF5 DEFECTIVE SLC35A2 CAUSES CONGENITAL DISORDER OF GLYCOSYLATION 2M (CDG2M)%REACTOME%R-HSA-5619072.1 Defective SLC35A2 causes congenital disorder of glycosylation 2M (CDG2M) SLC35A2 TWIK-RELEATED ACID-SENSITIVE K+ CHANNEL (TASK)%REACTOME%R-HSA-1299316.1 TWIK-releated acid-sensitive K+ channel (TASK) KCNK3 KCNK9 PI3K AKT ACTIVATION%REACTOME%R-HSA-198203.3 PI3K AKT activation PIK3R1 PIK3CB PIK3CA PIK3R2 NTRK1 RHOA IRS1 IRS2 NGF SEALING OF THE NUCLEAR ENVELOPE (NE) BY ESCRT-III%REACTOME%R-HSA-9668328.1 Sealing of the nuclear envelope (NE) by ESCRT-III VPS4A CHMP2A TUBA8 TUBA1C CHMP2B TUBA1B CHMP4C TUBA1A CHMP4B CHMP3 CHMP4A CHMP6 TUBB8P12 TUBB8 TUBB2B SPAST TUBB2A CHMP7 LEMD2 CC2D1B TUBAL3 TUBB6 TUBB3 TUBB1 TUBA3E IST1 TUBA4B TUBA4A TUBB4B TUBB4A SIGNALING BY INSULIN RECEPTOR%REACTOME DATABASE ID RELEASE 72%74752 Signaling by Insulin receptor PDPK1 PTPN11 TRIB3 FGF6 PIK3R2 FGF9 FGF20 FGF1 FGF2 FGF23 FGF3 FGF22 FGF10 FGF4 PIK3R4 KLB IRS1 FLT3 PDE3B IRS2 GRB10 THEM4 INSR FLT3LG GAB2 FGF19 TCIRG1 FGFR4 ATP6V1E1 ATP6V1E2 ATP6V1G1 ATP6V0B ATP6V0E1 ATP6V1G2 ATP6AP1 MAPK1 MAPK3 ATP6V1B2 ATP6V0C ATP6V0D2 ATP6V1B1 ATP6V1A FRS2 FGF16 FGF7 ATP6V0A2 TLR9 ATP6V1H FGF18 ATP6V0A4 INS ATP6V0E2 ATP6V1G3 ATP6V1D SHC1 ATP6V1C1 GAB1 ATP6V1F PIK3R1 ATP6V0A1 ATP6V1C2 PIK3CA SOS1 PIK3C3 HRAS NRAS PIK3CB AKT2 ATP6V0D1 SYNTHESIS OF DOLICHYL-PHOSPHATE MANNOSE%REACTOME%R-HSA-162699.1 Synthesis of dolichyl-phosphate mannose DPM1 DPM2 DPM3 CELLULAR RESPONSE TO HYPOXIA%REACTOME DATABASE ID RELEASE 72%1234174 Cellular response to hypoxia PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 UBA52 PSMD10 TCEB2 PSMB11 TCEB1 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 VHL EP300 PSMB6 PSMB7 PSMB4 UBE2D1 PSMB5 PSMB2 UBB PSMB3 UBC PSMB1 PSMF1 RPS27A SHFM1 PSMB8 UBE2D2 PSMB9 UBE2D3 PSMC5 HIF3A PSMC6 LIMD1 PSMC3 CUL2 PSMC4 EPO EGLN1 PSMC1 EGLN3 PSMC2 EGLN2 WTIP HIF1AN EPAS1 HIF1A ARNT CREBBP CITED2 AJUBA PSMD8 PSMD9 VEGFA PSMD6 RBX1 PSMD7 PSMD4 PSMD5 PSMD2 CA9 HIGD1A THROMBOXANE SIGNALLING THROUGH TP RECEPTOR%REACTOME%R-HSA-428930.2 Thromboxane signalling through TP receptor GNG11 GNG13 GNB2 GNB1 GNB4 GNB3 GNG3 GNG2 GNG5 GNB5 GNG4 GNG7 GNAQ GNG8 GNGT1 GNA13 GNGT2 GNA14 GNA15 GNG10 GNA11 TBXA2R GNG12 AAMP FORMATION OF THE EARLY ELONGATION COMPLEX%REACTOME DATABASE ID RELEASE 72%113418 Formation of the Early Elongation Complex GTF2F1 GTF2F2 CDK7 POLR2A POLR2B POLR2C POLR2D POLR2G POLR2E NELFB MNAT1 POLR2F NELFA NELFCD POLR2H POLR2I POLR2J NELFE POLR2K CCNH POLR2L GTF2H1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 ERCC3 ERCC2 CTDP1 NCBP1 NCBP2 SUPT4H1 SUPT5H TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G1 CELL CYCLE ARREST%REACTOME%R-HSA-6804116.3 TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest CCNE2 E2F1 ZNF385A CCNE1 E2F7 E2F8 CDK2 TP53 CDKN1A CDKN1B ARID3A CCNA2 CCNA1 PCBP4 G ALPHA (Z) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 72%418597 G alpha (z) signalling events GNG11 GNG13 GNB2 PRKCD PRKCA GNB1 GNB4 GNB3 GNAS GNB5 PRKCG GNGT1 ADRA2C ADRA2A GNGT2 ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 PRKCQ GNAI3 GNAT3 GNAI1 RGS17 GNAI2 RGS19 RGSL1 RGS16 GNG3 RGS4 GNG2 GNG5 RGS20 GNG4 PRKCH GNG7 GNG8 PRKCE GNAZ GNG10 ADCY9 PRKCB GNG12 TIE2 SIGNALING%REACTOME DATABASE ID RELEASE 72%210993 Tie2 Signaling HRAS PTPN11 NRAS SHC1 PIK3R1 PIK3CB GRB7 PIK3R2 PIK3CA ANGPT4 ANGPT2 SOS1 ANGPT1 DOK2 GRB14 TEK DEFECTIVE SLC6A18 MAY CONFER SUSCEPTIBILITY TO IMINOGLYCINURIA AND OR HYPERGLYCINURIA%REACTOME%R-HSA-5619079.1 Defective SLC6A18 may confer susceptibility to iminoglycinuria and or hyperglycinuria SLC6A18 REGULATION OF TLR BY ENDOGENOUS LIGAND%REACTOME%R-HSA-5686938.3 Regulation of TLR by endogenous ligand HMGB1 FGB FGA TLR1 FGG APOB TLR6 TLR2 S100A9 S100A8 CD36 LY96 CD14 TLR4 S100A1 LBP BETA OXIDATION OF PALMITOYL-COA TO MYRISTOYL-COA%REACTOME DATABASE ID RELEASE 72%77305 Beta oxidation of palmitoyl-CoA to myristoyl-CoA HADHB ACADVL HADHA DEFECTIVE SLC9A9 CAUSES AUTISM 16 (AUTS16)%REACTOME DATABASE ID RELEASE 72%5619052 Defective SLC9A9 causes autism 16 (AUTS16) SLC9A9 INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION%REACTOME DATABASE ID RELEASE 72%168273 Influenza Viral RNA Transcription and Replication RPL26 GRSF1 RPL29 RPL10L RPS4X RPL10A RPL28 RPS3A POLR2E POLR2F RPL23A POLR2H FAU NUP107 NUP188 POLR2K RPL41 POLR2L RPL3L NUP62 NDC1 NUP214 SEC13 NUP133 NUP210 NUP93 NUP50 NUP54 RPL10 RPL12 RPL13A RPL11 RPS3 POM121 RPL14 NUP205 RPL13 RPS2 AAAS RPL15 NUP160 RPL18 GTF2F1 RPL17 GTF2F2 RPL19 NUP85 POLR2A TPR POLR2B RPL27A POLR2C NUP88 POLR2D NUP43 POLR2G RAE1 POLR2I POLR2J RANBP2 NUP155 NUP153 NUP35 NUPL2 RPS9 RPS7 RPS8 NUP37 RPS5 RPS6 RPSA RPS15 RPS14 RPS17 RPS16 RPS19 RPL18A RPL36AL RPS18 RPLP1 RPS11 RPS10 RPLP0 RPS13 RPS12 RPLP2 RPL7A RPS27L UBA52 RPL37A RPS26 RPS25 RPS28 RPS27 RPL36A RPS29 RPS20 RPL35A RPS21 RPS24 RPS23 RPL22L1 RPS4Y2 RPS4Y1 RPS27A RPL26L1 RPL4 RPL39L RPL5 HSP90AA1 RPL30 RPL3 RPL32 RPL31 RPL34 RPL8 RPL9 RPL6 RPL7 RPL36 RPL35 RPL38 RPL37 RPL39 RPS15A RPL21 RPL23 RPL22 DNAJC3 IPO5 RPL24 RPL27 SHC1 EVENTS IN ERBB4 SIGNALING%REACTOME%R-HSA-1250347.3 SHC1 events in ERBB4 signaling SHC1 HRAS NRG1 NRG2 SOS1 BTC NRG3 NRG4 NRAS HBEGF EREG TLR3 DEFICIENCY - HSE%REACTOME DATABASE ID RELEASE 72%5602410 TLR3 deficiency - HSE TLR3 INTERLEUKIN-12 FAMILY SIGNALING%REACTOME%R-HSA-447115.5 Interleukin-12 family signaling CFL1 CAPZA1 HSPA9 SOD1 CANX JAK2 PSME2 SOD2 CDC42 IL23R IL27 IL27RA IL12B IL12A SERPINB2 IL23A BOLA2 SNRPA1 MIF LCP1 PAK2 RALA RAP1B EBI3 BOLA2B HNRNPDL STAT4 IL12RB1 IL12RB2 MSN MTAP HNRNPF VAMP7 HNRNPA2B1 PDCD4 JAK1 LMNB1 STAT1 PPIA ANXA2 GSTA2 IL10 GSTO1 TCP1 AIP CNN2 IFNG TYK2 ARF1 PITPNA P4HB IL6ST CRLF1 RPLP0 STAT3 CA1 TALDO1 ASSEMBLY OF THE ORC COMPLEX AT THE ORIGIN OF REPLICATION%REACTOME DATABASE ID RELEASE 72%68616 Assembly of the ORC complex at the origin of replication ORC4 ORC6 ORC1 ORC3 ORC2 ORC5 DEFECTIVE ABCC2 CAUSES DUBIN-JOHNSON SYNDROME%REACTOME%R-HSA-5679001.2 Defective ABCC2 causes Dubin-Johnson syndrome ABCC2 DEFECTIVE PGM1 CAUSES PGM1-CDG (CDG1T)%REACTOME%R-HSA-5609974.2 Defective PGM1 causes PGM1-CDG (CDG1t) PGM1 DEFECTIVE INTRINSIC PATHWAY FOR APOPTOSIS DUE TO P14ARF LOSS OF FUNCTION%REACTOME DATABASE ID RELEASE 72%9645722 Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function CDKN2A C1QBP PYROPHOSPHATE HYDROLYSIS%REACTOME DATABASE ID RELEASE 72%71737 Pyrophosphate hydrolysis PPA2 PPA1 TNF SIGNALING%REACTOME DATABASE ID RELEASE 72%75893 TNF signaling BAG4 USP2 IKBKB SHARPIN SMPD3 CHUK SMPD2 GNB2L1 CYLD OTUD7B CASP8 TRADD TNFAIP3 UBA52 RIPK1 TRAF2 FADD IKBKG TRAF1 TNFRSF1A TAX1BP1 SPPL2B SPPL2A BIRC2 TNF BIRC3 RNF31 UBB ADAM17 XIAP USP4 UBC CLIP3 RPS27A USP21 RBCK1 OTULIN NSMAF TAB3 TAB2 TAB1 MAP3K7 INTERLEUKIN-7 SIGNALING%REACTOME%R-HSA-1266695.7 Interleukin-7 signaling SMARCA4 PIK3R1 PIK3R2 BRWD1 HIST2H3A HIST2H3D PIK3R3 HGF SOCS1 HIST2H3C STAT5A STAT5B IRS1 HIST1H3J IRS2 HIST1H3A HIST1H3F HIST1H3G HIST1H3H IL2RG HIST1H3I SOCS2 JAK1 HIST1H3B JAK3 HIST1H3C TSLP STAT3 HIST1H3D CISH RAG2 HIST1H3E IL7 RAG1 CRLF2 IL7R BIOSYNTHESIS OF D-SERIES RESOLVINS%REACTOME DATABASE ID RELEASE 72%9018676 Biosynthesis of D-series resolvins LTA4H HPGD ALOX5 SYNTHESIS AND PROCESSING OF GAG, GAGPOL POLYPROTEINS%REACTOME DATABASE ID RELEASE 72%174495 Synthesis And Processing Of GAG, GAGPOL Polyproteins TSG101 MVB12B MVB12A VPS37C VPS37D UBB VPS37A NMT2 VPS37B UBC UBAP1 RPS27A UBA52 VPS28 PTK6 REGULATES PROTEINS INVOLVED IN RNA PROCESSING%REACTOME DATABASE ID RELEASE 72%8849468 PTK6 Regulates Proteins Involved in RNA Processing PTK6 SFPQ KHDRBS1 KHDRBS2 KHDRBS3 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE%REACTOME DATABASE ID RELEASE 72%204998 Cell death signalling via NRAGE, NRIF and NADE NCSTN CASP2 BCL2L11 APH1B VAV1 VAV2 ECT2 ARHGEF33 ARHGEF35 ARHGEF37 ARHGEF7 ARHGEF39 ARHGEF38 NET1 RASGRF2 ARHGEF10L AATF AKAP13 CASP3 UBA52 MCF2L MAPK8 PSENEN ARHGEF11 TIAM1 ARHGEF10 ARHGEF12 PLEKHG2 ARHGEF15 ARHGEF17 PLEKHG5 ARHGEF16 ARHGEF19 ARHGEF9 ARHGEF3 ARHGEF4 ARHGEF1 ARHGEF2 SOS2 ARHGEF5 NGFR UBB FGD1 FGD2 FGD3 UBC GNA13 FGD4 RPS27A MCF2 ITGB3BP BAD SOS1 TRIO ARHGEF18 ITSN1 PREX1 ARHGEF40 OBSCN NGFRAP1 YWHAE NGEF TRAF6 ARHGEF6 ARHGEF26 MAGED1 SQSTM1 PSEN2 PSEN1 RAC1 KALRN TIAM2 VAV3 NGF APH1A ABR FGFR1B LIGAND BINDING AND ACTIVATION%REACTOME%R-HSA-190370.2 FGFR1b ligand binding and activation FGF1 FGF2 FGF3 FGF22 FGF10 RAF-INDEPENDENT MAPK1 3 ACTIVATION%REACTOME DATABASE ID RELEASE 72%112409 RAF-independent MAPK1 3 activation DUSP5 DUSP2 MAP2K1 DUSP1 MAP2K2 DUSP8 DUSP4 DUSP9 PTPN11 DUSP16 IL6 DUSP10 PEA15 DUSP6 TYK2 DUSP7 CDK1 JAK2 IL6R JAK1 MAPK1 MAPK3 ALPHA-OXIDATION OF PHYTANATE%REACTOME%R-HSA-389599.2 Alpha-oxidation of phytanate PECR SLC25A17 SLC27A2 PHYH HACL1 MITOCHONDRIAL CALCIUM ION TRANSPORT%REACTOME%R-HSA-8949215.2 Mitochondrial calcium ion transport PHB VDAC1 SPG7 PHB2 PARL AKAP1 LETM1 AFG3L2 SMDT1 C2orf47 VDAC3 VDAC2 YME1L1 PMPCB MICU3 PMPCA MICU2 MICU1 MCU SLC8B1 SLC8A3 STOML2 CCDC109B VITAMIN B2 (RIBOFLAVIN) METABOLISM%REACTOME%R-HSA-196843.2 Vitamin B2 (riboflavin) metabolism FLAD1 SLC52A2 SLC52A3 RFK SLC52A1 ACP5 ENPP1 INTRACELLULAR METABOLISM OF FATTY ACIDS REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 72%434313 Intracellular metabolism of fatty acids regulates insulin secretion CD36 ACSL4 ACSL3 TRIF(TICAM1)-MEDIATED TLR4 SIGNALING%REACTOME DATABASE ID RELEASE 72%937061 TRIF(TICAM1)-mediated TLR4 signaling CUL1 MAP2K1 MAPKAPK3 PTPN11 UBA52 MAPK8 PPP2R1B ATF1 PPP2R1A APP ATF2 NFKBIA IKBKG IKBKE ELK1 RELA RPS6KA3 RPS6KA5 RPS6KA2 RPS6KA1 DUSP4 PPP2R5D MEF2A MEF2C UBE2D1 DUSP3 BIRC2 FOS BIRC3 VRK3 UBB DUSP6 DUSP7 UBC CREB1 MAPKAPK2 RPS27A IRF3 UBE2D2 TRAF3 MAPK7 UBE2D3 MAPK1 MAPK3 PPP2CA HMGB1 PPP2CB IKBKB NKIRAS1 NKIRAS2 MAPK14 MAP3K8 MAP2K3 CHUK MAPK11 MAP2K4 RIPK2 UBE2N UBE2V1 CASP8 NOD1 NFKB1 NOD2 NFKB2 AGER MAPK9 IRAK1 RIPK1 MAP2K6 S100A12 MAP2K7 FADD S100B MAPK10 TNIP2 JUN SAA1 NFKBIB FBXW11 TBK1 RIPK3 IRF7 TANK BTRC SKP1 IRAK2 TRAF6 TICAM2 TAB3 LY96 TAB2 TICAM1 TAB1 MAP3K7 CD14 TLR4 SCAVENGING BY CLASS F RECEPTORS%REACTOME%R-HSA-3000484.1 Scavenging by Class F Receptors CALR SCARF1 HSP90AA1 APOB HSPH1 HYOU1 TP53 REGULATES TRANSCRIPTION OF SEVERAL ADDITIONAL CELL DEATH GENES WHOSE SPECIFIC ROLES IN P53-DEPENDENT APOPTOSIS REMAIN UNCERTAIN%REACTOME%R-HSA-6803205.1 TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain TP53I3 BCL6 TP53 TP73 NDRG1 RABGGTB RABGGTA PERP BCL2L14 TP53BP2 PPP1R13B CHM BIRC5 TP63 ANCHORING FIBRIL FORMATION%REACTOME DATABASE ID RELEASE 72%2214320 Anchoring fibril formation COL7A1 LAMC2 LAMA3 LAMB3 BMP1 TLL2 TLL1 VITAMIN B5 (PANTOTHENATE) METABOLISM%REACTOME DATABASE ID RELEASE 72%199220 Vitamin B5 (pantothenate) metabolism PANK3 PANK1 PPCDC PPCS ENPP2 ENPP1 ENPP3 AASDHPPT COASY PDZD11 SLC5A6 SLC25A16 FASN PANK4 VNN1 VNN2 PANK2 FMO OXIDISES NUCLEOPHILES%REACTOME DATABASE ID RELEASE 72%217271 FMO oxidises nucleophiles FMO1 FMO2 FMO3 PHASE 0 - RAPID DEPOLARISATION%REACTOME DATABASE ID RELEASE 72%5576892 Phase 0 - rapid depolarisation CAMK2D CAMK2A CACNA2D4 CACNG6 CACNG7 CACNG8 CACNB1 SCN7A SCN10A CACNB4 CACNG2 CAMK2G SCN8A CACNG3 CACNG4 CACNA2D2 CACNA1F CACNA1S SCN3B RANGRF SCN3A FGF14 CACNA1D CACNA1C SCN2A CACNB2 FGF13 CACNB3 FGF12 FGF11 SCN2B SCN11A SCN5A SCN9A SCN1B SCN1A CACNA2D1 CACNA2D3 SCN4A SCN4B CAMK2B SYNTHESIS OF PIPS AT THE ER MEMBRANE%REACTOME%R-HSA-1483248.6 Synthesis of PIPs at the ER membrane PI4K2B MTMR2 SACM1L SBF1 REGULATION OF TP53 ACTIVITY THROUGH METHYLATION%REACTOME DATABASE ID RELEASE 72%6804760 Regulation of TP53 Activity through Methylation EP300 PRMT5 TTC5 ATM JMY UBB TP53 MDM2 L3MBTL1 SMYD2 UBC EHMT2 MDM4 EHMT1 SETD8 RPS27A UBA52 SETD9 CHEK2 TRANSFER OF LPS FROM LBP CARRIER TO CD14%REACTOME DATABASE ID RELEASE 72%166020 Transfer of LPS from LBP carrier to CD14 CD14 LBP PI METABOLISM%REACTOME%R-HSA-1483255.5 PI Metabolism SBF1 SBF2 VAC14 PITPNB OCRL PIK3R2 RAB5A MTM1 TMEM55B RAB4A PI4K2B PTPN13 SYNJ2 SYNJ1 PIK3C2G PIK3C2A PIK3R4 PIK3R3 PIP5K1A PIK3C2B PIP5K1B PIP5K1C GDE1 PIK3R6 PIK3R5 PI4K2A BMX GDPD1 SACM1L RUFY1 GDPD3 GDPD5 PIP4K2A PNPLA7 MTMR10 PIP4K2B MTMR12 PIP4K2C INPP4A MTMR14 INPP4B TPTE MTMR1 PNPLA6 MTMR2 INPPL1 MTMR3 PIK3CD MTMR8 INPP5F PIK3CG MTMR9 INPP5D FIG4 MTMR4 INPP5E ENPP6 INPP5J TPTE2 PIK3R1 INPP5K MTMR6 PIK3CA MTMR7 RAB14 PIKFYVE PIK3C3 TNFAIP8L1 TNFAIP8L3 ARF3 TNFAIP8L2 ARF1 PLEKHA1 TNFAIP8 PIK3CB PLEKHA5 PLEKHA6 PI4KB PLEKHA3 PTEN PLEKHA4 PLEKHA8 DEFECTIVE SLC24A4 CAUSES HYPOMINERALIZED AMELOGENESIS IMPERFECTA (AI)%REACTOME%R-HSA-5619055.1 Defective SLC24A4 causes hypomineralized amelogenesis imperfecta (AI) SLC24A4 RNA POLYMERASE III TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 72%76046 RNA Polymerase III Transcription Initiation POLR2E POLR2F POLR2H GTF3C1 GTF3C2 GTF3C3 GTF3C4 POLR2K GTF3C5 POLR2L GTF3C6 SNAPC5 SNAPC1 SNAPC2 SNAPC3 SNAPC4 ZNF143 BRF2 BRF1 GTF3A BDP1 TBP CRCP POLR1C POLR3GL POLR3A POLR3B POLR3C POLR3D POU2F1 POLR3E POLR3F POLR3G POLR3H POLR3K REGULATION OF COMMISSURAL AXON PATHFINDING BY SLIT AND ROBO%REACTOME DATABASE ID RELEASE 72%428542 Regulation of commissural axon pathfinding by SLIT and ROBO NTN1 ROBO2 NELL2 SLIT1 SLIT3 SLIT2 ROBO1 SRC DCC BDNF ACTIVATES NTRK2 (TRKB) SIGNALING%REACTOME%R-HSA-9024909.1 BDNF activates NTRK2 (TRKB) signaling NTRK2 BDNF REGULATION OF RUNX3 EXPRESSION AND ACTIVITY%REACTOME%R-HSA-8941858.1 Regulation of RUNX3 expression and activity PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 CBFB PSMA2 PSME3 PSME1 PSME2 UBA52 PSMD10 PSMD12 PSMD11 PSMD14 PSMD13 CDKN2A PSMA7 PSMB10 EP300 PSMB6 PSMB7 SMURF2 PSMB4 PSMB5 PSMB2 UBB PSMB3 UBC PSMB1 PSMF1 RPS27A SHFM1 PSMB8 PSMB9 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 TGFB1 SMURF1 RUNX3 MDM2 PSMD8 PSMD9 PSMD6 SRC PSMD7 PSMD4 PSMD5 PSMD2 VITAMIN E%REACTOME%R-HSA-8877627.1 Vitamin E TTPA SIGNAL TRANSDUCTION BY L1%REACTOME%R-HSA-445144.1 Signal transduction by L1 NCAM1 CSNK2A2 MAP2K1 MAP2K2 VAV2 NRP1 L1CAM ITGA2B CSNK2B ITGA5 ITGA9 ITGB3 ITGB1 EGFR PAK1 ITGAV MAPK1 RAC1 MAPK3 CSNK2A1 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE%REACTOME DATABASE ID RELEASE 72%606279 Deposition of new CENPA-containing nucleosomes at the centromere RBBP4 STRA13 RBBP7 CASC5 HIST1H2AE HIST1H2AD HIST3H2BB HIST1H2AC HIST1H2AB HIST1H2AJ NPM1 HIST1H2BF HIST1H2BE HIST1H2BH HIST1H2BG HIST1H2BB HIST1H2BA HIST1H2BD HIST1H2BC H2AFB1 HJURP RSF1 MIS18BP1 OIP5 CENPW MIS18A HIST1H4K ITGB3BP HIST1H4L CENPA SMARCA5 CENPC H2BFS HIST1H4A HIST1H4B HIST1H4H CENPT HIST1H4I CENPU HIST1H4J APITD1 HIST1H4C CENPH HIST1H4D CENPI HIST1H4E CENPK CENPL HIST1H4F HIST2H2AA3 CENPM CENPN HIST2H2AA4 RUVBL1 CENPO CENPP CENPQ HIST2H2AC H2AFJ H2AFZ H2AFX H2AFV HIST2H2BE HIST4H4 HIST1H2BN HIST1H2BM HIST1H2BO HIST1H2BJ HIST1H2BI HIST1H2BL HIST1H2BK HIST2H4A HIST2H4B PKA-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%R-HSA-111931.1 PKA-mediated phosphorylation of CREB PRKAR2B PRKAR2A PRKX CREB1 NBEA ADCY4 ADCY3 PRKACG ADCY2 ADCY1 ADCY9 PRKACA ADCY8 PRKAR1B PRKACB ADCY7 ADCY6 PRKAR1A ADCY5 NCAM SIGNALING FOR NEURITE OUT-GROWTH%REACTOME DATABASE ID RELEASE 72%375165 NCAM signaling for neurite out-growth NCAM1 SPTAN1 COL4A2 FYN COL4A1 COL6A2 RPS6KA5 COL4A4 COL6A1 COL4A3 PTK2 COL9A1 COL6A3 COL4A5 COL9A3 COL6A6 COL9A2 COL6A5 CREB1 MAPK1 MAPK3 CACNB1 CACNB4 NRTN GFRA1 SPTB GFRA2 GFRA4 SPTBN4 SPTBN5 CACNA1H CACNA1G SPTA1 CACNA1S SOS1 CACNA1I SPTBN1 SPTBN2 PRNP PSPN GDNF PTPRA ARTN CNTN2 CACNA1D ST8SIA4 CACNA1C HRAS CACNB2 CACNB3 ST8SIA2 NRAS NCAN AGRN RHO GTPASES REGULATE CFTR TRAFFICKING%REACTOME%R-HSA-5627083.1 RHO GTPases regulate CFTR trafficking GOPC CFTR RHOQ MET INTERACTS WITH TNS PROTEINS%REACTOME%R-HSA-8875513.1 MET interacts with TNS proteins ITGB1 HGF MET TNS4 TNS3 METABOLISM OF INGESTED SEMET, SEC, MESEC INTO H2SE%REACTOME DATABASE ID RELEASE 72%2408508 Metabolism of ingested SeMet, Sec, MeSec into H2Se CTH MAT1A NNMT AHCY CBS GNMT HNMT SCLY ORC1 REMOVAL FROM CHROMATIN%REACTOME%R-HSA-68949.3 Orc1 removal from chromatin PSMD3 CUL1 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 CCNA2 CCNA1 UBA52 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 UBB PSMB3 UBC PSMB1 PSMF1 RPS27A SHFM1 PSMB8 PSMB9 SKP2 PSMC5 PSMC6 PSMC3 ORC5 PSMC4 ORC4 PSMC1 ORC6 PSMC2 ORC1 ORC3 ORC2 CDT1 CDC6 MCM7 MCM8 MCM3 MCM4 MCM5 MCM6 MCM2 CDK2 SKP1 PSMD8 PSMD9 PSMD6 RBX1 PSMD7 PSMD4 PSMD5 PSMD2 TRAF6 MEDIATED IRF7 ACTIVATION%REACTOME%R-HSA-933541.4 TRAF6 mediated IRF7 activation IFNA4 IFNA7 IFNA6 IFNA1 IFNA2 IFNA8 IFNA13 IFNA14 IFNA16 IFNA17 IFNA10 IFNA21 TRAF2 IKBKE CREBBP IFIH1 EP300 RNF135 TBK1 MAVS SIKE1 IRF7 TRIM25 TANK DDX58 IFNB1 IRF3 TRAF6 IFNA5 UPTAKE AND ACTIONS OF BACTERIAL TOXINS%REACTOME DATABASE ID RELEASE 72%5339562 Uptake and actions of bacterial toxins MAP2K1 VAMP1 MAP2K2 MAP2K4 HSP90AB1 SYT2 GUCY2C PDZD3 SV2B SV2A STX1A SV2C HBEGF PDCD6IP STX1B VAMP2 TXNRD1 MAP2K7 CD9 HSP90AA1 FURIN SNAP25 SYT1 EEF2 TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN CYTOCHROME C RELEASE%REACTOME DATABASE ID RELEASE 72%6803204 TP53 Regulates Transcription of Genes Involved in Cytochrome C Release AIFM2 TP53INP1 ATM TP53 TP73 STEAP3 PMAIP1 TP53AIP1 TP53BP2 ZNF420 PPP1R13B SLMO1 BAX BID BNIP3L TRIAP1 PRELID1 BBC3 TP63 CREBBP MINERALOCORTICOID BIOSYNTHESIS%REACTOME%R-HSA-193993.2 Mineralocorticoid biosynthesis CYP21A2 CGA HSD3B2 HSD3B1 CYP11B2 LHB PLCG1 EVENTS IN ERBB2 SIGNALING%REACTOME DATABASE ID RELEASE 72%1251932 PLCG1 events in ERBB2 signaling EGFR PLCG1 ERBB2 EGF SIGNALING BY FGFR2 IIIA TM%REACTOME DATABASE ID RELEASE 72%8851708 Signaling by FGFR2 IIIa TM GTF2F1 GTF2F2 POLR2A POLR2B POLR2C POLR2D POLR2G POLR2E POLR2F POLR2H POLR2I POLR2J POLR2K POLR2L FGFR2 FGF1 FGF2 NCBP1 NCBP2 DEFECTIVE ABCA3 CAUSES PULMONARY SURFACTANT METABOLISM DYSFUNCTION TYPE 3 (SMDP3)%REACTOME%R-HSA-5683678.1 Defective ABCA3 causes pulmonary surfactant metabolism dysfunction type 3 (SMDP3) ABCA3 THE FATTY ACID CYCLING MODEL%REACTOME%R-HSA-167826.3 The fatty acid cycling model UCP1 SLC25A27 UCP3 UCP2 SLC25A14 INTERCONVERSION OF POLYAMINES%REACTOME DATABASE ID RELEASE 72%351200 Interconversion of polyamines PAOX SAT1 DNA DAMAGE RECOGNITION IN GG-NER%REACTOME DATABASE ID RELEASE 72%5696394 DNA Damage Recognition in GG-NER MCRS1 NFRKB ACTR5 RAD23A ACTR8 YY1 RAD23B DDB2 RUVBL1 COPS7B XPC CETN2 COPS7A TFPT UBA52 ACTB INO80C INO80 INO80B INO80E INO80D CUL4A UBB UBC PARP1 CUL4B PARP2 COPS4 ACTL6A COPS3 COPS6 RPS27A COPS5 COPS2 DDB1 RBX1 COPS8 GPS1 APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS%REACTOME%R-HSA-351906.1 Apoptotic cleavage of cell adhesion proteins DSG1 PKP1 TJP2 CDH1 DSG2 CASP3 DSG3 TJP1 OCLN DSP CTNNB1 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION%REACTOME DATABASE ID RELEASE 72%983168 Antigen processing: Ubiquitination & Proteasome degradation BTBD1 CUL1 LONRF1 UBE2F UBE2H KLHL25 ZBTB16 GLMN KLHL21 KLHL22 UBE2A BTBD6 FBXO30 KLHL20 FBXO31 UBE2W UBOX5 UBE2S UBE2U RNF182 UBE2O TPP2 BLMH CDC20 UBA1 UBE2K TRIM71 RNF14 KBTBD13 UFL1 UBE2Q1 UBE2Q2 RNF34 TRIM69 ZNF645 UNKL DTX3L ITCH PJA2 PJA1 TRAF7 UBE2R2 THOP1 TRIM50 MGRN1 VPRBP ASB13 ASB14 ASB11 RNF6 RNF7 ASB12 ASB17 ASB18 FBXL22 RNF213 ASB15 ASB16 FBXL20 ZNRF1 ZNRF2 HECTD1 HECTD2 ASB10 HECTD3 RBBP6 TRIM41 RNF25 FBXL19 FBXL15 FBXL16 FBXL13 LNPEP FBXL14 FZR1 FBXL12 TRIM39 ASB8 ASB9 LNX1 ASB6 ASB7 TRIM36 TRIM37 ASB4 ASB5 ASB2 ASB1 FBXW11 CUL3 SOCS1 KBTBD7 HERC2 RNF111 RNF41 VHL ANAPC7 UBE2C FBXO4 UBE2E1 FBXO6 UBE2D1 ANAPC10 ANAPC11 SOCS3 CDC23 CDC26 CDC34 FBXW4 CDC27 FBXW5 CDC16 FBXW10 FBXW7 FBXW9 ANAPC4 ANAPC5 FBXW2 ANAPC1 ANAPC2 UBE2D2 SKP2 UBE2D3 CUL2 FBXL3 FBXL5 NEDD4L CUL7 UBE2V2 SMURF1 TRIM21 UBE2B TRIM63 UBR4 FBXO32 TRIM32 RNF4 UBA3 RCHY1 WWP1 UBE2M STUB1 MKRN1 KCTD6 UBE2V1 HUWE1 FBXL7 FBXL18 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 UBA52 TCEB2 PSMD10 TCEB1 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 LRR1 PSMB10 CCNF PSMA8 KEAP1 ATG7 CBLB UBE2L3 PSMB6 HERC4 HERC3 PSMB7 SMURF2 RNF115 RNF114 PSMB4 UBE2L6 HERC1 FBXO7 PSMB5 FBXO9 PSMB2 HERC5 HERC6 UBB WSB1 PSMB3 FBXO2 RNF123 RNF126 UBC HECW2 PSMB1 TRIM11 PSMF1 ANAPC13 UBE2J2 RPS27A UBE2J1 RNF217 HACE1 SIAH2 SHFM1 SIAH1 MEX3C PSMB8 UBAC1 PSMB9 FBXL8 PSMC5 FBXL4 PSMC6 DZIP3 PSMC3 RNF220 PSMC4 UBA7 DET1 PSMC1 LRSAM1 PSMC2 SH3RF1 TRIM9 TRIM4 ARIH2 GPR75-ASB3 LRRC41 RNF144B GAN NEDD4 RNF138 UBE2N RNF130 KLHL2 KLHL3 UBE2G1 UBE2G2 KLHL9 SPSB2 SPSB1 KBTBD6 KLHL5 RLIM TRIP12 KBTBD8 SPSB4 UBE2D4 UBE3C UBE3D MYLIP FBXO27 LTN1 RNF19B UBE3A UBE3B FBXO21 UBE2Z FBXO22 PARK2 NPEPPS RNF19A FBXW12 AREL1 FBXW8 UBE2E3 FBXO17 UBE2E2 FBXO15 MIB2 UBE4A LMO7 FBXO10 FBXO11 KLHL41 TRAIP KLHL42 BTRC RBCK1 KCTD7 SKP1 CUL5 UBA6 UBA5 RBX1 KLHL11 UBR2 KLHL13 UBR1 FBXO44 FBXO41 FBXO40 MET ACTIVATES PI3K AKT SIGNALING%REACTOME DATABASE ID RELEASE 72%8851907 MET activates PI3K AKT signaling GAB1 PIK3R1 PIK3CA HGF MET LIPOPHAGY%REACTOME%R-HSA-9613354.2 Lipophagy PRKAB1 PLIN3 PLIN2 HSPA8 PRKAG1 PRKAG2 PRKAG3 PRKAA2 PRKAB2 REGULATION OF NECROPTOTIC CELL DEATH%REACTOME DATABASE ID RELEASE 72%5675482 Regulation of necroptotic cell death BIRC2 BIRC3 XIAP CASP8 TRADD TNFSF10 FAS TNFRSF10B FASLG RIPK1 TNFRSF10A TRAF2 FADD HSP90 CHAPERONE CYCLE FOR SHRS%REACTOME%R-HSA-3371497.2 HSP90 chaperone cycle for SHRs NR3C1 DCTN4 DYNC1I1 HSPA2 FKBP5 STIP1 HSP90AB1 CAPZA3 DYNC1H1 CAPZA1 PTGES3 CAPZA2 ACTR10 ACTR1A HSP90AA1 DYNC1LI1 DYNC1LI2 DCTN1 DNAJA1 DNAJA4 DNAJA2 AR CAPZB DYNLL1 DYNLL2 HSPA8 PGR FKBP4 DYNC1I2 DCTN2 NR3C2 DCTN6 DCTN3 DNAJB1 DCTN5 HSPA1L NGF-STIMULATED TRANSCRIPTION%REACTOME%R-HSA-9031628.1 NGF-stimulated transcription EGR2 JUND EGR3 EGR4 FOSL1 REST CDK5 ID2 ID1 ID4 FOSB ID3 CDK5R2 CDK5R1 ATF1 SH3GL3 ATF2 NAB1 NAB2 CHD4 ELK1 LYL1 EP300 JUNB TCF12 FOS F3 DNM2 ARC CREB1 VGF SGK1 TRIB1 TPH1 RRAD SRF ASCL1 MEF2D EGR1 DEFECTIVE ABCA12 CAUSES AUTOSOMAL RECESSIVE CONGENITAL ICHTHYOSIS TYPE 4B%REACTOME DATABASE ID RELEASE 72%5682294 Defective ABCA12 causes autosomal recessive congenital ichthyosis type 4B ABCA12 MULTIFUNCTIONAL ANION EXCHANGERS%REACTOME DATABASE ID RELEASE 72%427601 Multifunctional anion exchangers SLC26A2 SLC26A1 SLC26A7 SLC26A9 SLC26A4 SLC26A3 SLC26A6 SLC5A12 SLC26A11 CONSTITUTIVE SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%R-HSA-2660826.1 Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant ADAM10 DLL1 DLL4 JAG2 ADAM17 JAG1 NOTCH1 MPS IV - MORQUIO SYNDROME A%REACTOME%R-HSA-2206290.1 MPS IV - Morquio syndrome A GALNS SMAC, XIAP-REGULATED APOPTOTIC RESPONSE%REACTOME DATABASE ID RELEASE 72%111469 SMAC, XIAP-regulated apoptotic response CASP7 CASP3 CASP9 APAF1 DIABLO XIAP CYCS TRANSLESION SYNTHESIS BY REV1%REACTOME%R-HSA-110312.1 Translesion synthesis by REV1 RPA1 RPA2 RFC1 MAD2L2 RPA3 RFC5 REV1 RFC3 RFC4 UBB RFC2 REV3L UBC RPS27A UBA52 PCNA DISEASES OF GLYCOSYLATION%REACTOME%R-HSA-3781865.1 Diseases of glycosylation SDC4 SDC2 SDC3 NEU1 MOGS MUC20 KERA EXT1 MAN1B1 EXT2 SLC26A2 CHSY1 SDC1 LUM B4GALT1 DPM1 DPM2 HSPG2 DPM3 B4GAT1 CTSA B4GALT7 FMOD CHST6 PRELP B3GAT3 NOTCH2 NOTCH3 NOTCH4 LFNG DPAGT1 MPI ALG8 ALG9 ALG6 ALG14 ALG3 ALG2 ALG13 GPC1 ALG12 GPC3 ALG1 GPC2 ALG11 GPC5 DHDDS GPC4 GNE MPDU1 GPC6 NUS1 PMM2 CHST3 DOLK GALK1 HEXB RFT1 HEXA MGAT2 AGRN GALT GALE OGN POMT2 GALNT12 SEMA5A SEMA5B SPON2 SPON1 NOTCH1 THSD7B SRD5A3 POMT1 ADAMTSL1 B3GALT6 ADAMTS4 ADAMTS5 ADAMTS2 C1GALT1C1 ADAMTS3 ST3GAL3 ADAMTSL4 ADAMTS1 ADAMTSL3 ADAMTSL2 PGM1 MUC12 DAG1 MUC13 MUC15 THSD7A ADAMTS8 ADAMTS9 GLB1 ADAMTS6 ADAMTS7 SBSPON MUCL1 MUC3A POMGNT1 MUC5AC ADAMTS20 B3GLCT CFP ADAMTS12 THBS2 THSD1 THBS1 THSD4 ADAMTS10 ADAMTS16 ADAMTS15 ADAMTS14 MUC1 ADAMTS13 ADAMTS19 ADAMTS18 LARGE ADAMTS17 PAPSS2 MUC7 BCAN MUC4 VCAN MUC6 GFPT1 GALNT3 MUC17 NCAN C1GALT1 MUC5B MUC21 BGN CSPG5 CSPG4 CHST14 DCN OMD NEGATIVE REGULATION OF THE PI3K AKT NETWORK%REACTOME DATABASE ID RELEASE 72%199418 Negative regulation of the PI3K AKT network KIT AKT1 PHLPP2 PHLPP1 PDGFB PPP2R5B VAV1 ESR2 PPP2R5A STRN PIK3AP1 PTPN11 RAC2 TRIB3 RHOG PPP2R5C FGF6 PIK3R2 FGF9 PPP2R1B PPP2R1A FGF20 FGF1 FGF2 FGF23 FGF3 FYN FGF22 FGF10 FGF4 PPP2R5D IL1RL1 HGF PIK3R3 PIP5K1A MET PIP5K1B IL33 PIP5K1C KLB IRS1 IRS2 THEM4 INSR FGF19 FGFR4 PIP4K2A PIP4K2B PIP4K2C MAPK1 CD86 MAPK3 TRAT1 LCK CD80 PPP2CA PPP2CB CD28 NRG1 NRG2 FRS2 IRAK4 NRG3 FGF16 FGF7 NRG4 PIK3CD FGF18 INS ESR1 PDGFRA EGF GAB1 PIK3R1 EGFR PIK3CA IRAK1 ERBB2 MYD88 BTC EPGN TGFA AREG HBEGF EREG CD19 PIK3CB AKT2 AKT3 TRAF6 PTEN SRC RAC1 IER3 PPP2R5E PDGFRB MRNA CAPPING%REACTOME DATABASE ID RELEASE 72%72086 mRNA Capping GTF2F1 GTF2F2 CDK7 POLR2A POLR2B RNMT POLR2C POLR2D POLR2G POLR2E RNGTT MNAT1 POLR2F POLR2H POLR2I POLR2J POLR2K CCNH POLR2L GTF2H1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 ERCC3 ERCC2 NCBP1 NCBP2 SUPT5H RHESUS GLYCOPROTEINS MEDIATE AMMONIUM TRANSPORT.%REACTOME DATABASE ID RELEASE 72%444411 Rhesus glycoproteins mediate ammonium transport. RHAG RHCG RHBG SIGNALING BY CYTOSOLIC PDGFRA AND PDGFRB FUSION PROTEINS%REACTOME DATABASE ID RELEASE 72%9673766 Signaling by cytosolic PDGFRA and PDGFRB fusion proteins STRN WDR48 FIP1L1 NICOTINAMIDE SALVAGING%REACTOME%R-HSA-197264.5 Nicotinamide salvaging PTGIS CARKD SLC22A13 NAMPT PARP6 PARP4 PARP9 PARP8 NUDT12 PTGS2 RNLS APOA1BP NAPRT SLC5A8 PARP16 NNMT PARP14 CYP8B1 PARP10 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY%REACTOME DATABASE ID RELEASE 72%3301854 Nuclear Pore Complex (NPC) Disassembly NUP85 TPR NUP88 NUP43 RAE1 RANBP2 NUP107 NEK9 NUP155 NUP188 NEK6 NEK7 NUP153 NUP62 NUP35 NUPL2 NDC1 NUP214 SEC13 NUP37 NUP133 NUP210 NUP93 NUP50 CCNB1 NUP54 CDK1 POM121 NUP205 AAAS CCNB2 NUP160 ROLE OF ABL IN ROBO-SLIT SIGNALING%REACTOME%R-HSA-428890.2 Role of ABL in ROBO-SLIT signaling ABL2 CLASP2 CAP2 ABL1 SLIT2 CLASP1 ROBO1 CAP1 INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES%REACTOME%R-HSA-499943.6 Interconversion of nucleotide di- and triphosphates CTPS2 CTPS1 NUDT13 AK6 TXN RRM1 RRM2 DCTD DCTPP1 RRM2B CMPK1 GLRX TAF9 AK1 GUK1 AK2 AK4 DTYMK AK5 TXNRD1 AK7 AK8 NME2 AK9 NME3 NME4 TYMS NME1 MITOCHONDRIAL TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 72%163282 Mitochondrial transcription initiation TFB2M POLRMT TFAM METHIONINE SALVAGE PATHWAY%REACTOME DATABASE ID RELEASE 72%1237112 Methionine salvage pathway GOT1 APIP ENOPH1 MTAP MRI1 ADI1 LOSS OF MECP2 BINDING ABILITY TO 5MC-DNA%REACTOME DATABASE ID RELEASE 72%9022538 Loss of MECP2 binding ability to 5mC-DNA HDAC1 SIN3A S45 MUTANTS OF BETA-CATENIN AREN'T PHOSPHORYLATED%REACTOME DATABASE ID RELEASE 72%5358751 S45 mutants of beta-catenin aren't phosphorylated CSNK1A1 PPP2CA PPP2CB PPP2R5B PPP2R5A PPP2R5D CTNNB1 GSK3B PPP2R5C PPP2R1B PPP2R1A AMER1 AXIN1 APC PPP2R5E MTB IRON ASSIMILATION BY CHELATION%REACTOME%R-HSA-1222449.2 Mtb iron assimilation by chelation LTF REGULATION OF THYROID HORMONE ACTIVITY%REACTOME DATABASE ID RELEASE 72%350864 Regulation of thyroid hormone activity DIO1 DIO2 DIO3 HHAT G278V ABROGATES PALMITOYLATION OF HH-NP%REACTOME%R-HSA-5658034.1 HHAT G278V abrogates palmitoylation of Hh-Np HHAT SHH DHH IHH RESISTANCE OF ERBB2 KD MUTANTS TO TESEVATINIB%REACTOME%R-HSA-9665245.1 Resistance of ERBB2 KD mutants to tesevatinib ERBB2IP HSP90AA1 CDC37 ERBB2 SYNTHESIS OF CL%REACTOME DATABASE ID RELEASE 72%1483076 Synthesis of CL CRLS1 ACTIVATED PKN1 STIMULATES TRANSCRIPTION OF AR (ANDROGEN RECEPTOR) REGULATED GENES KLK2 AND KLK3%REACTOME%R-HSA-5625886.1 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 PKN1 HIST1H2AE HIST1H2AD HIST3H2BB HIST1H2AC HIST1H2AB HIST1H2AJ HIST2H3A HIST1H2BF HIST1H2BE AR HIST1H2BH HIST1H2BG HIST2H3D HIST1H2BB HIST1H2BA KDM1A HIST2H3C HIST1H2BD HIST1H2BC H2AFB1 HIST1H3J HIST1H3A HIST1H3F HIST1H3G HIST1H3H HIST1H3I HIST1H3B HIST1H3C HIST1H3D HIST1H3E H3F3B HIST1H4K HIST1H4L H3F3A H2BFS HIST1H4A HIST1H4B HIST1H4H HIST1H4I HIST1H4J HIST1H4C HIST1H4D HIST1H4E HIST1H4F HIST2H2AA3 HIST2H2AA4 HIST2H2AC H2AFJ NCOA2 H2AFZ H2AFX H2AFV HIST2H2BE HIST4H4 HIST1H2BN HIST1H2BM HIST1H2BO KDM4C HIST1H2BJ HIST1H2BI HIST1H2BL HIST1H2BK KLK3 KLK2 HIST2H4A HIST2H4B BETA OXIDATION OF HEXANOYL-COA TO BUTANOYL-COA%REACTOME DATABASE ID RELEASE 72%77350 Beta oxidation of hexanoyl-CoA to butanoyl-CoA HADH ACADS HADHB HADHA ECHS1 RESOLUTION OF D-LOOP STRUCTURES THROUGH HOLLIDAY JUNCTION INTERMEDIATES%REACTOME%R-HSA-5693568.1 Resolution of D-loop Structures through Holliday Junction Intermediates EXO1 WRN RMI2 DNA2 SPIDR RMI1 TOP3A EME1 RAD51D EME2 GEN1 BRIP1 SLX1B BARD1 XRCC2 XRCC3 MRE11A SLX1A RAD51AP1 RAD51 RBBP8 ATM BRCA2 PALB2 RAD51B KAT5 RAD50 RAD51C BRCA1 NBN MUS81 BLM SLX4 NEGATIVE REGULATION OF FGFR4 SIGNALING%REACTOME DATABASE ID RELEASE 72%5654733 Negative regulation of FGFR4 signaling PPP2CA PPP2CB BRAF FRS2 PTPN11 SPRY2 FGF16 FGF18 CBL UBA52 FGF6 FGF9 PPP2R1A FGF20 FGF1 FGF2 FGF23 MKNK1 FGF4 KLB UBB UBC FGF19 FGFR4 RPS27A MAPK1 MAPK3 ACTIVATION OF NMDA RECEPTORS AND POSTSYNAPTIC EVENTS%REACTOME DATABASE ID RELEASE 72%442755 Activation of NMDA receptors and postsynaptic events PDPK1 CASK GRIA2 CAMK2D LIN7A CAMK2A PRKAR2B LIN7C PRKAR2A LIN7B CAMK2G APBA1 GRIA3 RASGRF2 GRIA4 RPS6KA6 DLG2 DLG1 ACTN2 NBEA DLG4 DLG3 RASGRF1 CAMK4 NRGN PRKACG PRKACA ADCY1 PRKACB PRKAA1 ADCY8 GRIN2A PRKAA2 RPS6KA3 RPS6KA2 RPS6KA1 GRIN2C GRIN2B GRIN2D GRIN3B GRIN3A KPNA2 CREB1 PPM1E PPM1F KIF17 MAPK1 MAPK3 PRKAB2 PRKAB1 NEFL NRG1 GIT1 LRRC7 CAMKK1 CAMKK2 HRAS GRIN1 NRAS CAMK1 PRKX PRKAG1 PRKAG2 SRC PRKAG3 RAC1 PRKAR1B PRKAR1A GRIA1 CAMK2B ESSENTIAL FRUCTOSURIA%REACTOME%R-HSA-5657562.3 Essential fructosuria KHK INTERLEUKIN-21 SIGNALING%REACTOME%R-HSA-9020958.2 Interleukin-21 signaling IL21R IL2RG STAT1 JAK1 STAT4 JAK3 STAT3 STAT5A STAT5B IL21 DEFECTIVE SLC16A1 CAUSES SYMPTOMATIC DEFICIENCY IN LACTATE TRANSPORT (SDLT)%REACTOME%R-HSA-5619070.1 Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT) BSG SLC16A1 INHIBITION OF IFN-BETA%REACTOME%R-HSA-168888.4 Inhibition of IFN-beta CASP8 ACTIVITY IS INHIBITED%REACTOME%R-HSA-5218900.1 CASP8 activity is inhibited TRADD TNFSF10 FAS TNFRSF10B FASLG RIPK1 TNFRSF10A TRAF2 FADD CASP8 TP53 REGULATES TRANSCRIPTION OF DEATH RECEPTORS AND LIGANDS%REACTOME%R-HSA-6803211.1 TP53 Regulates Transcription of Death Receptors and Ligands FAS TNFRSF10B TP53BP2 TNFRSF10A PPP1R13B TMEM219 TNFRSF10C TP53 TP63 TP73 TNFRSF10D IGFBP3 HISTAMINE RECEPTORS%REACTOME%R-HSA-390650.1 Histamine receptors HRH1 HRH3 HRH4 HRH2 MPS VII - SLY SYNDROME%REACTOME DATABASE ID RELEASE 72%2206292 MPS VII - Sly syndrome GUSB NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10%REACTOME DATABASE ID RELEASE 72%933543 NF-kB activation through FADD RIP-1 pathway mediated by caspase-8 and -10 IKBKB CASP10 IFIH1 RNF135 DDX58 RIPK1 MAVS CHUK FADD IKBKG TRIM25 CASP8 RNA POLYMERASE III TRANSCRIPTION TERMINATION%REACTOME%R-HSA-73980.3 RNA Polymerase III Transcription Termination CRCP POLR2E POLR2F POLR2H SSB NFIX NFIA NFIB POLR1C POLR2K NFIC POLR2L POLR3GL POLR3A POLR3B POLR3C POLR3D POLR3E POLR3F POLR3G POLR3H POLR3K G1 S-SPECIFIC TRANSCRIPTION%REACTOME%R-HSA-69205.3 G1 S-Specific Transcription RBBP4 ORC1 CDT1 CDC6 POLA1 CCNE1 LIN54 LIN52 RBL2 RRM2 CCNA1 TFDP1 RBL1 LIN37 TFDP2 LIN9 CDC45 E2F5 TK1 E2F6 E2F1 E2F4 CDK1 DHFR HDAC1 TYMS FBXO5 PCNA LXRS REGULATE GENE EXPRESSION TO CONTROL BILE ACID HOMEOSTASIS%REACTOME DATABASE ID RELEASE 72%9623433 LXRs regulate gene expression to control bile acid homeostasis NCOR1 NR1H2 RXRB FABP6 RXRA UGT1A3 NCOA1 NR1H3 NCOR2 MRNA DECAY BY 3' TO 5' EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 72%429958 mRNA decay by 3' to 5' exoribonuclease EXOSC7 DIS3 EXOSC6 EXOSC5 EXOSC4 SKIV2L EXOSC9 EXOSC8 EXOSC3 EXOSC2 HBS1L EXOSC1 TTC37 WDR61 NT5C3B DCPS NON-INTEGRIN MEMBRANE-ECM INTERACTIONS%REACTOME DATABASE ID RELEASE 72%3000171 Non-integrin membrane-ECM interactions ITGB5 CASK LAMA5 SDC4 LAMA2 SDC2 LAMA1 SDC3 PDGFB LAMA4 DDR1 TTR ITGB4 LAMA3 PRKCA NTN4 LAMB3 TNC LAMB2 PDGFA DMD LAMB1 TRAPPC4 ACTN1 DAG1 ITGA6 DDR2 FGF2 SDC1 THBS1 TGFB1 VTN ITGB3 ITGB1 LAMC3 HSPG2 NRXN1 LAMC2 LAMC1 ITGAV ITGA2 AGRN DEFECTIVE ST3GAL3 CAUSES MCT12 AND EIEE15%REACTOME DATABASE ID RELEASE 72%3656243 Defective ST3GAL3 causes MCT12 and EIEE15 LUM KERA FMOD PRELP OMD ST3GAL3 OGN DDX58 IFIH1-MEDIATED INDUCTION OF INTERFERON-ALPHA BETA%REACTOME%R-HSA-168928.4 DDX58 IFIH1-mediated induction of interferon-alpha beta CASP10 CYLD TNFAIP3 UBA52 UBE2K APP NFKBIA IKBKG IKBKE RELA ITCH EP300 TAX1BP1 TKFC UBE2D1 UBE2L6 HERC5 UBB TRIM25 UBC RPS27A DDX58 IRF3 UBE2D2 TRAF3 UBE2D3 IFNA5 UBA7 IFNA4 IFNA7 HMGB1 IFNA6 IKBKB IFNA1 NKIRAS1 IFNA2 NKIRAS2 IFNA8 CHUK IFNA13 ISG15 IFNA14 IFNA16 IFNA17 IFNA10 IFNA21 CASP8 NFKB1 NFKB2 AGER RIPK1 S100A12 TRAF2 OTUD5 FADD MAP3K1 DHX58 S100B ATG12 RNF125 NLRX1 SAA1 NLRC5 RNF216 NFKBIB PCBP2 CREBBP ATG5 IFIH1 TBK1 RNF135 MAVS SIKE1 IRF7 PIN1 TANK IFNB1 TRAF6 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA-HYDROXYCHOLESTEROL%REACTOME DATABASE ID RELEASE 72%193368 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol PTGIS ACOX2 AKR1D1 BAAT RXRA CYP7B1 HSD17B4 ACOT8 HSD3B7 AKR1C1 AMACR AKR1C3 AKR1C2 ABCB11 NR1H4 CYP7A1 NCOA1 AKR1C4 SLC27A2 SLC27A5 CYP8B1 NCOA2 CYP27A1 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY%REACTOME%R-HSA-3371599.2 Defective HLCS causes multiple carboxylase deficiency PCCA ACACA PCCB HLCS MCCC2 MCCC1 PC FATTY ACIDS%REACTOME%R-HSA-211935.1 Fatty acids CYP4A11 CYP4B1 CYP2J2 CYP2A13 CYP2D6 CYP4F22 CYP4F2 CYP4F3 CYP4F8 CYP4A22 CYP2A7 CYP2F1 CYP2B6 CYP4F11 CYP4F12 PORPHYRIN METABOLISM%REACTOME DATABASE ID RELEASE 72%189445 Porphyrin metabolism ABCC1 FABP1 ALB HMOX1 ABCC2 CPOX ALAD BLVRB HMOX2 UROD UGT1A4 BLVRA COX10 FECH PPOX HMBS UROS GSTA1 ABCG2 SLCO1B1 SLCO1B3 COX15 ALAS2 ALAS1 PLUS-STRAND DNA SYNTHESIS%REACTOME DATABASE ID RELEASE 72%164525 Plus-strand DNA synthesis PPIA PROCESSING OF SMDT1%REACTOME DATABASE ID RELEASE 72%8949664 Processing of SMDT1 PHB SPG7 PHB2 PARL AFG3L2 SMDT1 C2orf47 YME1L1 PMPCB MICU3 PMPCA MICU2 MICU1 MCU STOML2 CCDC109B TOLL LIKE RECEPTOR 3 (TLR3) CASCADE%REACTOME DATABASE ID RELEASE 72%168164 Toll Like Receptor 3 (TLR3) Cascade CUL1 MAP2K1 MAPKAPK3 UBA52 MAPK8 PPP2R1B ATF1 PPP2R1A APP ATF2 NFKBIA IKBKG IKBKE ELK1 RELA RPS6KA3 RPS6KA5 RPS6KA2 RPS6KA1 DUSP4 PPP2R5D MEF2A MEF2C UBE2D1 DUSP3 BIRC2 FOS BIRC3 VRK3 UBB DUSP6 DUSP7 UBC CREB1 MAPKAPK2 RPS27A IRF3 UBE2D2 TRAF3 MAPK7 UBE2D3 TLR3 MAPK1 MAPK3 PPP2CA HMGB1 PPP2CB IKBKB NKIRAS1 NKIRAS2 MAPK14 MAP3K8 MAP2K3 CHUK MAPK11 MAP2K4 RIPK2 UBE2N UBE2V1 CASP8 NOD1 NFKB1 NOD2 NFKB2 AGER MAPK9 IRAK1 RIPK1 MAP2K6 S100A12 MAP2K7 FADD S100B MAPK10 TNIP2 JUN SAA1 NFKBIB FBXW11 TBK1 RIPK3 IRF7 TANK BTRC SKP1 IRAK2 TRAF6 TAB3 TAB2 TICAM1 TAB1 MAP3K7 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS%REACTOME DATABASE ID RELEASE 72%1362409 Mitochondrial iron-sulfur cluster biogenesis ISCA1 LYRM4 FXN SLC25A28 GLRX5 FDXR SLC25A37 FDX1 ISCA2 FDX1L HSCB NOTCH3 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME DATABASE ID RELEASE 72%9013508 NOTCH3 Intracellular Domain Regulates Transcription MAML2 HEY1 MAML1 HEY2 DLGAP5 STAT1 EP300 RBPJ PLXND1 WWC1 KAT2B HES1 KAT2A FABP7 HES5 PTCRA SNW1 HEYL MAML3 MAMLD1 PBX1 NOTCH3 CREBBP NOTCH1 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D%REACTOME DATABASE ID RELEASE 72%75815 Ubiquitin-dependent degradation of Cyclin D PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 UBA52 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 UBB PSMB3 CCND1 UBC PSMB1 PSMF1 RPS27A SHFM1 PSMB8 PSMB9 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 GSK3B CDK4 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 72%372708 p130Cas linkage to MAPK signaling for integrins RAP1B FGB FGA FN1 VWF PTK2 RAP1A CRK FGG ITGA2B BCAR1 ITGB3 APBB1IP SRC TLN1 BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME DATABASE ID RELEASE 72%70895 Branched-chain amino acid catabolism HIBADH DBT ECHS1 AUH IVD DLD PPM1K HSD17B10 BCAT1 SLC25A44 MCCC2 BCKDHA BCKDK ALDH6A1 MCCC1 BCKDHB ACAT1 BCAT2 ACAD8 ACADSB HIBCH ACTIVATED NTRK3 SIGNALS THROUGH PI3K%REACTOME%R-HSA-9603381.1 Activated NTRK3 signals through PI3K PIK3R1 PIK3CA NTF3 SRC IRS1 NTRK3 APC TRUNCATION MUTANTS HAVE IMPAIRED AXIN BINDING%REACTOME DATABASE ID RELEASE 72%5467337 APC truncation mutants have impaired AXIN binding CSNK1A1 PPP2CA PPP2CB PPP2R5B PPP2R5A PPP2R5D GSK3B PPP2R5C PPP2R1B PPP2R1A AMER1 AXIN1 APC PPP2R5E PRESYNAPTIC PHASE OF HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME%R-HSA-5693616.1 Presynaptic phase of homologous DNA pairing and strand exchange EXO1 HUS1 RPA1 RPA2 TOPBP1 WRN RPA3 RMI2 RFC5 DNA2 RFC3 RMI1 RFC4 TOP3A RHNO1 RFC2 RAD51D BRIP1 ATRIP BARD1 XRCC2 MRE11A RAD51 RBBP8 RAD17 ATM BRCA2 RAD1 ATR RAD9B RAD9A RAD51B KAT5 RAD50 CHEK1 RAD51C BRCA1 NBN BLM CALCINEURIN ACTIVATES NFAT%REACTOME DATABASE ID RELEASE 72%2025928 Calcineurin activates NFAT PPP3CA PPP3CB NFATC2 NFATC3 NFATC1 PPIA FKBP1A PPP3R1 INTERLEUKIN-12 SIGNALING%REACTOME DATABASE ID RELEASE 72%9020591 Interleukin-12 signaling LMNB1 CFL1 CAPZA1 HSPA9 SOD1 PPIA ANXA2 JAK2 PSME2 SOD2 GSTA2 IL10 CDC42 GSTO1 IL12B IL12A TCP1 SERPINB2 BOLA2 SNRPA1 PAK2 MIF LCP1 RALA RAP1B AIP BOLA2B HNRNPDL STAT4 IL12RB1 CNN2 IL12RB2 MSN MTAP IFNG HNRNPF VAMP7 HNRNPA2B1 PDCD4 TYK2 ARF1 PITPNA P4HB JAK1 RPLP0 CA1 TALDO1 CLASSICAL ANTIBODY-MEDIATED COMPLEMENT ACTIVATION%REACTOME DATABASE ID RELEASE 72%173623 Classical antibody-mediated complement activation IGHG1 C1QB IGHG2 IGKV3-11 C1QA IGKV1-12 C1S C1R CRP IGKV2D-28 IGKV4-1 IGKV2-28 IGKV2D-30 IGKV5-2 C1QC IGKV3D-20 IGHG4 GSD IA%REACTOME%R-HSA-3274531.2 GSD Ia G6PC CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE%REACTOME%R-HSA-211897.2 Cytochrome P450 - arranged by substrate type CYP4A11 CYP46A1 CYP3A43 ARNT2 CYP11A1 CYP1A2 CYP1A1 CYP2F1 CYP2S1 CYP2C19 CYP2C18 CYP11B2 CYP11B1 CYP2D6 CYP7B1 CYP4F2 CYP4F3 CYP4F8 CYP4V2 CYP19A1 TBXAS1 CYP7A1 CYP8B1 CYP26A1 CYP27A1 CYP2E1 CYP27B1 CYP26B1 CYP24A1 PTGIS CYP26C1 CYP3A4 CYP2R1 CYP3A5 CYP3A7 CYP2W1 CYP51A1 AHR ARNT CYP2A7 CYP2A6 NCOA1 POMC CYP2B6 NCOA2 CYP21A2 AHRR CYP4B1 FDXR CYP1B1 RXRA CYP2A13 CYP2J2 CYP2C9 CYP2C8 CYP4F22 CYP3A7-CYP3A51P CYP4A22 NR1H4 CYP39A1 FDX1 CYP4F11 FDX1L POR CYP4F12 CYP2U1 DEFECTIVE HEXA CAUSES GM2G1%REACTOME DATABASE ID RELEASE 72%3656234 Defective HEXA causes GM2G1 HEXA STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES%REACTOME%R-HSA-1834941.3 STING mediated induction of host immune responses DDX41 TBK1 TRIM21 MB21D1 TMEM173 NLRC3 PRKDC DTX4 IFI16 NLRP4 STAT6 TREX1 IRF3 XRCC6 XRCC5 MRE11A FORMATION OF RNA POL II ELONGATION COMPLEX%REACTOME DATABASE ID RELEASE 72%112382 Formation of RNA Pol II elongation complex TCEB3C TCEB3B POLR2E POLR2F POLR2H TCEB3CL2 POLR2K CCNH POLR2L TCEB3 GTF2H1 TCEB2 GTF2H2 TCEB1 GTF2H3 TCEB3CL GTF2H4 GTF2H5 ERCC3 ERCC2 TCEA1 CCNK CCNT2 CCNT1 SSRP1 WDR61 CTDP1 NCBP1 LEO1 SUPT16H NCBP2 SUPT4H1 SUPT5H GTF2F1 GTF2F2 CDK7 POLR2A POLR2B POLR2C POLR2D POLR2G NELFB MNAT1 NELFA NELFCD POLR2I POLR2J NELFE CDC73 CDK9 ELL AFF4 CTR9 MLLT1 RTF1 MLLT3 SUPT6H IWS1 EAF1 EAF2 PAF1 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME DATABASE ID RELEASE 72%2979096 NOTCH2 Activation and Transmission of Signal to the Nucleus NCSTN ADAM10 APH1B DLL1 DLL4 NEURL1B CNTN1 JAG2 UBB JAG1 MIB2 MDK MIB1 UBC NEURL1 RPS27A UBA52 PSENEN PSEN2 NOTCH2 PSEN1 APH1A HEME DEGRADATION%REACTOME DATABASE ID RELEASE 72%189483 Heme degradation ABCC1 FABP1 ALB HMOX1 ABCC2 BLVRB HMOX2 UGT1A4 BLVRA GSTA1 ABCG2 SLCO1B1 SLCO1B3 SCAVENGING BY CLASS A RECEPTORS%REACTOME DATABASE ID RELEASE 72%3000480 Scavenging by Class A Receptors FTH1 COLEC12 COLEC11 MSR1 SCARA5 MARCO APOE SCGB3A2 APOB MASP1 FTL HSP90B1 CALR APOA1 COL1A1 COL3A1 COL1A2 COL4A2 COL4A1 DEFECTIVE SLC1A1 IS IMPLICATED IN SCHIZOPHRENIA 18 (SCZD18) AND DICARBOXYLIC AMINOACIDURIA (DCBXA)%REACTOME DATABASE ID RELEASE 72%5619067 Defective SLC1A1 is implicated in schizophrenia 18 (SCZD18) and dicarboxylic aminoaciduria (DCBXA) SLC1A1 CELL CYCLE CHECKPOINTS%REACTOME%R-HSA-69620.2 Cell Cycle Checkpoints EXO1 TOPBP1 YWHAG ZNF385A YWHAH RFC5 RFC3 RFC4 RFC2 PPP2R5C ERCC6L ZWILCH BUB1B CCNA2 CASC5 CCNA1 CDC20 KNTC1 DYNC1LI1 BIRC5 DYNC1LI2 CLIP1 ZW10 MAD1L1 CDCA8 PMF1 SKA1 AURKB SKA2 DSN1 RCC2 RBBP8 NDC80 ZWINT KIF18A SGOL2 SGOL1 NUF2 SPDL1 NDEL1 NUDC DYNLL2 KIF2A RAD50 INCENP KIF2C KIF2B ITGB3BP MIS12 CENPA NSL1 CENPC BUB3 BUB1 DYNC1I1 CLASP2 CENPT CENPU CENPE CENPF CENPH CENPI TAOK1 CENPK CENPL CENPM CENPN B9D2 CENPO CENPP CENPQ SPC24 MAD2L1 SPC25 DYNLL1 CKAP5 MAPRE1 PAFAH1B1 DYNC1I2 CCNB2 HERC2 CLASP1 DYNC1H1 NDE1 BRCC3 TP53BP1 HIST3H2BB HIST1H2BF HIST1H2BE ANAPC15 HIST1H2BH ANAPC16 HIST1H2BG ANAPC7 HIST1H2BB UBE2C PLK1 HIST1H2BA UBE2E1 UBE2D1 HIST1H2BD ANAPC10 HIST1H2BC ANAPC11 CCNB1 CDC23 BABAM1 CDC26 UIMC1 CDC27 CDC16 CDK1 ANAPC4 ANAPC5 ANAPC1 ANAPC2 RNF168 HIST1H4K HIST1H4L CDC25A ORC5 H2BFS HIST1H4A ORC4 ORC6 HIST1H4B ORC1 HIST1H4H ORC3 HIST1H4I ORC2 HIST1H4J CDC7 HIST1H4C APITD1 CDC6 HIST1H4D HIST1H4E MCM7 HIST1H4F MCM8 MCM10 DBF4 MCM3 MCM4 MCM5 MCM6 MCM2 CDC45 UBE2V2 WEE1 H2AFX HIST2H2BE CLSPN HIST4H4 HIST1H2BN HIST1H2BM HIST1H2BO HIST1H2BJ FAM175A HIST1H2BI HIST1H2BL HIST1H2BK HIST2H4A HIST2H4B BLM WHSC1 RPA1 RPA2 GTSE1 WRN RPA3 PPP1CC DNA2 NUP107 RNF8 PPP2R1B PPP2R1A SEC13 NUP133 PPP2R5D BRE HIST3H3 MDC1 KAT5 CHEK2 CHEK1 NUP160 HUS1 PPP2CA PPP2CB NUP85 NUP43 RANBP2 TP53 RHNO1 BRIP1 PCBP4 SFN ATRIP BARD1 NUP37 RAD17 ATM ATR CDKN1A CDKN1B YWHAB PHF20 PSMD8 PSMD9 PSMD6 BRCA1 XPO1 PSMD7 PSMD4 PSMD5 PSMD2 SUMO1 PPP2R5E PSMD3 PSMD1 PPP2R5B PPP2R5A YWHAZ RMI2 PSMA5 PSMA6 PSMA3 RMI1 PSMA4 TOP3A PSMA1 PSMA2 PSME3 PIAS4 PSME4 PSME1 PSME2 UBA52 PSMD10 PSMB11 PSMD12 PSMD11 RPS27 PSMD14 PSMD13 CDKN2A PSMA7 MRE11A PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 RAD1 UBB PSMB3 RFWD2 UBC PSMB1 PSMF1 RPS27A SHFM1 PSMB8 NBN PSMB9 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 CDC25C CCNE2 AHCTF1 CCNE1 RANGAP1 UBE2N PKMYT1 CDK2 MDM2 MDM4 RAD9B RAD9A YWHAE YWHAQ DRUG RESISTANCE OF PDGFR MUTANTS%REACTOME%R-HSA-9674415.1 Drug resistance of PDGFR mutants PDGFRA SIGNALING BY SCF-KIT%REACTOME%R-HSA-1433557.3 Signaling by SCF-KIT KIT LYN STAT1 VAV1 YES1 PRKCA PTPN11 CMA1 PTPN6 JAK2 PIK3R1 CBL PIK3R2 PIK3CA PTPRU SOCS6 SOS1 SH2B3 FER TEC FES FYN GRAP HRAS PIK3R3 SOCS1 STAT5A STAT5B NRAS GRB10 GAB2 GRB7 STAT3 GRAP2 CHEK1 MMP9 RAC1 LCK PAUSING AND RECOVERY OF TAT-MEDIATED HIV ELONGATION%REACTOME DATABASE ID RELEASE 72%167238 Pausing and recovery of Tat-mediated HIV elongation GTF2F1 GTF2F2 POLR2A POLR2B TCEB3C POLR2C POLR2D TCEB3B POLR2G POLR2E NELFB POLR2F NELFA NELFCD POLR2H POLR2I POLR2J NELFE POLR2K TCEB3CL2 POLR2L TCEB3 TCEB2 TCEB1 TCEB3CL CDK9 TCEA1 ELL CCNT1 SSRP1 CTDP1 SUPT16H SUPT4H1 SUPT5H APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%R-HSA-176409.2 APC C:Cdc20 mediated degradation of mitotic proteins PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 BUB1B CCNA2 CCNA1 UBA52 CDC20 PSMD10 PTTG1 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 ANAPC15 ANAPC16 PSMB6 ANAPC7 PSMB7 UBE2C UBE2E1 PSMB4 UBE2D1 ANAPC10 PSMB5 ANAPC11 PSMB2 CCNB1 UBB CDC23 PSMB3 CDC26 CDC27 UBC CDC16 PSMB1 CDK1 ANAPC4 PSMF1 ANAPC5 ANAPC1 RPS27A ANAPC2 SHFM1 PSMB8 PSMB9 PSMC5 PSMC6 PSMC3 PSMC4 BUB3 PSMC1 PSMC2 MAD2L1 NEK2 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 CELLULAR HEXOSE TRANSPORT%REACTOME DATABASE ID RELEASE 72%189200 Cellular hexose transport SLC2A8 FGF21 SLC2A14 SLC2A1 SLC45A3 SLC2A2 SLC2A11 SLC2A3 SLC2A10 SLC2A12 SLC5A10 SLC50A1 SLC2A4 SLC5A1 SLC5A2 SLC2A6 SLC2A7 SLC5A4 SLC5A9 KIAA1919 SLC2A9 HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME DATABASE ID RELEASE 72%629594 Highly calcium permeable postsynaptic nicotinic acetylcholine receptors CHRNA1 CHRNB2 CHRNB4 CHRNA3 CHRNB3 CHRNA2 CHRNA5 CHRNA4 CHRNA7 CHRNA6 CHRNA9 CYSTEINE FORMATION FROM HOMOCYSTEINE%REACTOME%R-HSA-1614603.2 Cysteine formation from homocysteine CTH CBS TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G2 CELL CYCLE ARREST%REACTOME%R-HSA-6804114.2 TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest GADD45A CDC25C AURKA EP300 ZNF385A E2F4 PRMT1 CCNB1 TP53 CDK1 RBL2 TFDP1 RBL1 TFDP2 SFN CARM1 BAX PCNA GSD 0 (MUSCLE)%REACTOME%R-HSA-3828062.2 GSD 0 (muscle) GYS1 GYG1 DEFECTIVE ALG11 CAUSES ALG11-CDG (CDG-1P)%REACTOME%R-HSA-4551295.1 Defective ALG11 causes ALG11-CDG (CDG-1p) ALG11 MET ACTIVATES RAS SIGNALING%REACTOME%R-HSA-8851805.1 MET activates RAS signaling HRAS HGF SOS1 MET RANBP9 RANBP10 NRAS MUC20 MYD88:MAL(TIRAP) CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME%R-HSA-166058.3 MyD88:MAL(TIRAP) cascade initiated on plasma membrane CUL1 MAP2K1 MAPKAPK3 UBA52 MAPK8 PPP2R1B ATF1 PPP2R1A APP ATF2 NFKBIA IKBKG ELK1 RELA RPS6KA3 RPS6KA5 RPS6KA2 RPS6KA1 DUSP4 PPP2R5D MEF2A MEF2C IRAK3 DUSP3 TIRAP TLR1 FOS SIGIRR VRK3 TLR6 UBB TLR2 DUSP6 DUSP7 UBC CREB1 MAPKAPK2 RPS27A MAPK7 MAPK1 MAPK3 PPP2CA HMGB1 PPP2CB IKBKB NKIRAS1 NKIRAS2 MAPK14 MAP3K8 MAP2K3 CHUK MAPK11 MAP2K4 RIPK2 IRAK4 PELI1 UBE2N UBE2V1 PELI3 PELI2 NOD1 NFKB1 NOD2 NFKB2 AGER MAPK9 IRAK1 MAP2K6 S100A12 MAP2K7 MAP3K1 CD36 S100B MAPK10 TNIP2 JUN SAA1 MYD88 NFKBIB FBXW11 SOCS1 BTRC ECSIT SKP1 BTK IRAK2 TRAF6 TAB3 LY96 TAB2 TAB1 MAP3K7 CD14 TLR4 PRE-NOTCH EXPRESSION AND PROCESSING%REACTOME%R-HSA-1912422.1 Pre-NOTCH Expression and Processing TFDP1 TFDP2 E2F1 B4GALT1 CCND1 TNRC6C TNRC6A TNRC6B POGLUT1 E2F3 POFUT1 TP53 ELF3 NOTCH2 NOTCH3 JUN NOTCH4 RFNG CREBBP LFNG MFNG TMED2 RAB6A MOV10 AGO3 AGO4 AGO1 AGO2 ATP2A3 ATP2A2 ATP2A1 FURIN RUNX1 HIST1H2AE HIST1H2AD HIST3H2BB HIST1H2AC HIST1H2AB HIST1H2AJ HIST2H3A HIST1H2BF HIST1H2BE HIST1H2BH EP300 HIST1H2BG HIST2H3D HIST1H2BB HIST1H2BA HIST2H3C HIST1H2BD HIST1H2BC H2AFB1 HIST1H3J HIST1H3A HIST1H3F HIST1H3G HIST1H3H HIST1H3I SIRT6 HIST1H3B HIST1H3C HIST1H3D HIST1H3E H3F3B HIST1H4K HIST1H4L H3F3A NOTCH1 H2BFS MAML2 ST3GAL4 HIST1H4A MAML1 ST3GAL6 HIST1H4B HIST1H4H HIST1H4I RBPJ HIST1H4J HIST1H4C ST3GAL3 HIST1H4D HIST1H4E HIST1H4F HIST2H2AA3 SNW1 HIST2H2AA4 MAML3 HIST2H2AC MAMLD1 H2AFJ H2AFZ H2AFX H2AFV HIST2H2BE KAT2B KAT2A HIST4H4 PRKCI HIST1H2BN HIST1H2BM HIST1H2BO HIST1H2BJ HIST1H2BI HIST1H2BL HIST1H2BK SEL1L HIST2H4A HIST2H4B DEFECTIVE DPM3 CAUSES DPM3-CDG (CDG-1O)%REACTOME DATABASE ID RELEASE 72%4719360 Defective DPM3 causes DPM3-CDG (CDG-1o) DPM1 DPM2 DPM3 TP53 REGULATES TRANSCRIPTION OF CELL DEATH GENES%REACTOME DATABASE ID RELEASE 72%5633008 TP53 Regulates Transcription of Cell Death Genes CASP1 AIFM2 CASP2 CASP10 TP53 APAF1 NDRG1 RABGGTB PMAIP1 RABGGTA FAS PERP TNFRSF10B BCL2L14 TP53BP2 ZNF420 TNFRSF10A SLMO1 BIRC5 BID TMEM219 TNFRSF10C PRELID1 TNFRSF10D CREBBP CRADD NLRC4 TP53I3 TP53INP1 BCL6 ATM TP73 STEAP3 TP53AIP1 PPP1R13B CHM BAX TRIAP1 BNIP3L PIDD1 BBC3 TP63 CASP6 IGFBP3 FORMATION OF THE HIV-1 EARLY ELONGATION COMPLEX%REACTOME DATABASE ID RELEASE 72%167158 Formation of the HIV-1 Early Elongation Complex GTF2F1 GTF2F2 CDK7 POLR2A POLR2B POLR2C POLR2D POLR2G POLR2E NELFB MNAT1 POLR2F NELFA NELFCD POLR2H POLR2I POLR2J NELFE POLR2K CCNH POLR2L GTF2H1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 ERCC3 ERCC2 CTDP1 NCBP1 NCBP2 SUPT4H1 SUPT5H CONSTITUTIVE SIGNALING BY EGFRVIII%REACTOME%R-HSA-5637810.1 Constitutive Signaling by EGFRvIII HRAS NRAS EGF SHC1 GAB1 PIK3R1 CBL EGFR PIK3CA PLCG1 SOS1 HSP90AA1 CDC37 ADENYLATE CYCLASE ACTIVATING PATHWAY%REACTOME DATABASE ID RELEASE 72%170660 Adenylate cyclase activating pathway ADCY4 ADCY3 ADCY2 ADCY9 ADCY1 ADCY8 ADCY7 ADCY6 GNAL ADCY5 MPS IIID - SANFILIPPO SYNDROME D%REACTOME%R-HSA-2206305.2 MPS IIID - Sanfilippo syndrome D GNS LEUKOTRIENE RECEPTORS%REACTOME%R-HSA-391906.1 Leukotriene receptors LTB4R CYSLTR2 GPR17 CYSLTR1 LTB4R2 DEFECTIVE SLC22A12 CAUSES RENAL HYPOURICEMIA 1 (RHUC1)%REACTOME%R-HSA-5619071.1 Defective SLC22A12 causes renal hypouricemia 1 (RHUC1) SLC22A12 DRUG-MEDIATED INHIBITION OF ERBB2 SIGNALING%REACTOME DATABASE ID RELEASE 72%9652282 Drug-mediated inhibition of ERBB2 signaling ERBB2IP HSP90AA1 CDC37 ERBB2 GSD IB%REACTOME%R-HSA-3229133.2 GSD Ib FOXO-MEDIATED TRANSCRIPTION OF CELL DEATH GENES%REACTOME%R-HSA-9614657.1 FOXO-mediated transcription of cell death genes BCL2L11 EP300 CITED2 FOXO3 BCL6 NFYA NFYB NFYC DDIT3 FASLG STK11 FOXO1 BBC3 PINK1 CREBBP FOXO4 REV-MEDIATED NUCLEAR EXPORT OF HIV RNA%REACTOME%R-HSA-165054.2 Rev-mediated nuclear export of HIV RNA NUP85 TPR NUP88 NUP43 RANGAP1 RCC1 RAE1 RANBP2 NUP107 NUP155 NUP188 RANBP1 NUP153 RAN NUP62 NUP35 NUPL2 NDC1 NUP214 SEC13 NUP37 NUP133 NUP210 NUP93 NUP50 NUP54 POM121 XPO1 NUP205 AAAS NUP160 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS%REACTOME DATABASE ID RELEASE 72%168643 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways CASP1 CASP2 TXNIP P2RX7 MEFV CYLD TNFAIP3 PYCARD NLRP3 APP IKBKG RELA PSTPIP1 NLRC4 ITCH SUGT1 MAPK12 MAPK13 BIRC2 BIRC3 PANX1 IKBKB MAPK14 CASP4 BCL2L1 CHUK AIM2 MAPK11 NLRP1 BCL2 HSP90AB1 CASP9 RIPK2 CARD9 UBE2N UBE2V1 CASP8 TXN NOD1 NFKB1 NOD2 NFKB2 IRAK1 MAP2K6 IRAK2 TRAF6 TAB3 TAB2 TAB1 MAP3K7 AAMP ACTIVATION OF GABAB RECEPTORS%REACTOME DATABASE ID RELEASE 72%991365 Activation of GABAB receptors GNG11 GNG13 KCNJ3 KCNJ5 GNB2 KCNJ6 KCNJ10 GNB1 GNB4 KCNJ2 KCNJ9 KCNJ15 GNB3 KCNJ4 KCNJ16 KCNJ12 GNB5 GNAL GNGT1 GNGT2 ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 GABBR2 GABBR1 GNAI3 GNAT3 GNAI1 GNAI2 GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 GNG10 ADCY9 GNG12 BETA-CATENIN PHOSPHORYLATION CASCADE%REACTOME%R-HSA-196299.1 Beta-catenin phosphorylation cascade CSNK1A1 PPP2CA PPP2CB FRAT1 PPP2R5B FRAT2 PPP2R5A PPP2R5D CTNNB1 GSK3B PPP2R5C PPP2R1B PPP2R1A AMER1 AXIN1 APC PPP2R5E DEFECTIVE FMO3 CAUSES TRIMETHYLAMINURIA (TMAU)%REACTOME%R-HSA-5579019.1 Defective FMO3 causes Trimethylaminuria (TMAU) FMO3 OLIGOMERIZATION OF CONNEXINS INTO CONNEXONS%REACTOME%R-HSA-190704.1 Oligomerization of connexins into connexons GJA1 GJB2 GJB1 DEFECTIVE MAOA CAUSES BRUNNER SYNDROME (BRUNS)%REACTOME DATABASE ID RELEASE 72%5579012 Defective MAOA causes Brunner syndrome (BRUNS) MAOA CLASSICAL KIR CHANNELS%REACTOME%R-HSA-1296053.1 Classical Kir channels KCNJ2 KCNJ4 KCNJ12 KCNJ14 ADAPTIVE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 72%1280218 Adaptive Immune System BTBD1 CUL1 LONRF1 UBE2F DCTN4 CDH1 KIF3A UBE2H KLHL25 ZBTB16 GLMN KLHL21 CAPZA3 KLHL22 KIF26A UBE2A BTBD6 FBXO30 CAPZA1 CAPZA2 KLHL20 FBXO31 UBE2W UBOX5 PPP2R5C UBE2S ACTR10 UBE2U RNF182 UBE2O TPP2 BLMH CDC20 UBA1 UBE2K TRIM71 DYNC1LI1 RNF14 DYNC1LI2 KBTBD13 SNAP23 UFL1 UBE2Q1 RNF34 UBE2Q2 TRIM69 ZNF645 UNKL DTX3L ITCH PJA2 PJA1 TRAF7 SH3GL2 UBE2R2 THOP1 TRIM50 MGRN1 VAMP8 TIRAP VPRBP TLR1 ASB13 KIF18A ASB14 CTSV TLR6 ASB11 TLR2 RNF6 CTSS RNF7 CTSL ASB12 CTSK ASB17 CTSB ASB18 FBXL22 RNF213 ASB15 ASB16 DYNLL2 FBXL20 ZNRF1 STX4 ZNRF2 KIF2A HECTD1 HECTD2 KIF2C KIF2B ASB10 HECTD3 RBBP6 TRIM41 RNF25 CD86 PPP3R1 LCK FBXL19 FBXL15 CD80 FBXL16 CD28 FBXL13 DYNC1I1 LNPEP FBXL14 FZR1 FBXL12 SEC61A2 TRIM39 SEC61A1 CENPE SEC61G ASB8 SEC61B ASB9 VAMP3 LNX1 ASB6 ASB7 TRIM36 TRIM37 PPIA ASB4 ASB5 ASB2 ASB1 HRAS CUL3 NRAS KBTBD7 ARF1 C3 PIK3AP1 RNF41 NFKBIA IKBKG VHL ANAPC7 UBE2C FBXO4 UBE2E1 UBE2D1 FBXO6 ANAPC10 ANAPC11 SOCS3 CDC23 FBXW4 THEM4 CDC26 CDC34 FBXW5 CDC27 CARD11 CD101 CDC16 FBXW10 BCL10 FBXW7 FBXW9 ANAPC4 VASP ANAPC5 TRAV19 FBXW2 ANAPC1 LAT ITK ANAPC2 PTPN22 CD3E CD3D ENAH ZAP70 EVL MALT1 SKP2 FYB TRAT1 PIK3CD FBXL3 FBXL5 PIK3R1 PIK3CA PLCG1 SOS1 SEC23A PPP3CA SMURF1 PPP3CB NFATC3 NFATC1 FKBP1A SEC24B SEC24A DNM1 COLEC12 DNM3 TNFRSF14 SEC24D SEC24C UBA3 MAP3K14 PPP2R1B PPP2R1A UBE2M PRKACG PRKACA PRKACB TREM1 RELA SAR1B CD300LB SEC13 KIR2DS2 NCR2 CD300E PPP2R5D PIK3R3 CD40LG BLNK KIF5B KIF5A CTSD LGMN CTSA PPP2CA PPP2CB STIM1 ORAI2 ORAI1 KCTD6 NFKB1 CD36 IFI30 ICAM1 PRR5 HLA-DPA1 AHCYL1 RAPGEF3 NCF1 NCF2 CLTC RAPGEF4 NCF4 CLTA AP2A1 PIK3CB AP2B1 AP2A2 AP2S1 AKT2 AKT3 TREM2 KLRK1 AP2M1 TRPC1 MLST8 GRAP2 HLA-DQB2 ITGAV TYROBP HLA-DQB1 LCP2 RAC1 NCK1 KLRD1 PRKCB PDPK1 CYBB FCGR1B CYBA VAV1 HLA-DQA2 HLA-DQA1 TRIB3 HLA-DRB5 BLK VCAM1 HLA-DRB4 HLA-DPB1 MAPKAP1 HLA-DRA HLA-DRB3 ITPR1 HLA-DRB1 ITPR2 ITPR3 PIK3R2 CDC42 ICOSLG PDCD1LG2 PAK1 MRC2 CD274 MRC1 BTLA RICTOR PDCD1 CD207 FYN PAK3 PAK2 MTOR RAP1A DNM2 IFITM1 HSPA5 ERAP2 ERAP1 CXADR HLA-B TREML1 TAP2 TREML4 OSBPL1A HLA-C TREML2 TAP1 REL HLA-F CD200R1 HLA-G HCST HLA-E HLA-DMA TAPBP HLA-DMB SEC31A KIR3DL1 KIR3DL2 SIGLEC1 SIGLEC8 SIGLEC7 SIGLEC6 HLA-DOA HLA-DOB LAG3 BTN1A1 CLEC4G RAP1GAP CD300LD CD300LF CD300LG BTN2A2 CD160 BTN2A1 ITGB7 PIANP ITGA4 RILP CLEC2B FCGR2B CLEC2D PVRL2 ICAM2 ICAM3 ICAM4 ICAM5 CD226 CD1D CD1C PPL CD1B CD1A CD79B CD79A SLAMF7 SLAMF6 SIGLEC12 SIGLEC11 SH2D1A SIGLEC10 SH2D1B PILRB ITGB1 PILRA RAET1E CD209 RBCK1 CD200 CD22 PTPRJ CTSO CTSF CTSE BTN3A1 BTN3A3 BTN3A2 NCR1 NCR3 LILRA6 LILRA1 LILRA2 LILRA4 LILRA5 NCR3LG1 LAIR2 PDIA3 MICA MICB NPDC1 PLCG2 CD74 LILRB1 LILRB4 LILRB5 SIPA1 PVR CANX CD96 CD8A CALR KLRF1 CD300C KLRB1 DAPP1 KIR2DL1 KIR2DL2 RASGRP2 KIR2DL3 RASGRP1 KIR2DL4 RASGRP3 KLRC1 CD99 BTNL9 RAP1GAP2 BTNL8 CRTAM IGKV1-12 BTNL2 NFKBIE ULBP1 ULBP3 AMICA1 KLRG1 IGKV2D-28 IGKV4-1 IGKV2D-30 XDH ITGB5 IGKV3-11 LYN YES1 CD3G FCGR3A IGKV2-28 SYK ACTR1A IGKV3D-20 FBXW11 SOCS1 DYNLL1 FCGR1A IGKV5-2 DYNC1I2 DCTN2 DCTN3 HERC2 RNF111 DYNC1H1 WAS RAB7A PRKCQ UBE2D2 UBE2D3 CUL2 SIGLEC9 INPP5D NEDD4L SPTBN2 CUL7 DCTN1 UBE2V2 SIGLEC5 TRIM21 UBE2B TRIM63 UBR4 FBXO32 PTPRC TRIM32 ITGB2 ITGAL RAF1 RNF4 RCHY1 WWP1 CD4 CD8B STUB1 ACTR1B CTSH CTSC CD33 IKBKB MAP3K8 CHUK RIPK2 LILRA3 MKRN1 UBE2V1 LAIR1 HUWE1 LILRB2 LILRB3 CD81 MYD88 NFKBIB CD300A OSCAR AP1G1 AP1S2 FBXL7 AP1B1 SELL AP1S1 RACGAP1 AP1S3 HLA-A B2M AP1M2 CD19 AP1M1 FBXL18 YWHAB PSMD8 PSMD9 PSMD6 SH3KBP1 LY96 PSMD7 PSMD4 CD14 PSMD5 CSK TLR4 PSMD2 PPP2R5E PSMD3 PAG1 AKT1 PSMD1 PPP2R5B PPP2R5A PTPN11 YWHAZ PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PTPN6 PSME1 PSME2 UBA52 TCEB2 PSMD10 TCEB1 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 LRR1 PSMB10 PSMA8 RAP1B CCNF ATG7 KEAP1 CBLB PSMB6 UBE2L3 HERC4 NFATC2 PSMB7 HERC3 SMURF2 RNF115 CTLA4 RNF114 PSMB4 UBE2L6 HERC1 PSMB5 FBXO7 PSMB2 FBXO9 HERC5 HERC6 UBB WSB1 PSMB3 FBXO2 RNF123 RNF126 UBC HECW2 PSMB1 PSMF1 TRIM11 ANAPC13 RPS27A UBE2J2 UBE2J1 RNF217 HACE1 SHFM1 SIAH2 SIAH1 MEX3C PSMB8 PSMB9 UBAC1 PSMC5 FBXL8 PSMC6 FBXL4 DZIP3 PSMC3 RNF220 PSMC4 UBA7 PSMC1 DET1 LRSAM1 PSMC2 SH3RF1 TRIM9 TRIM4 ARIH2 GPR75-ASB3 LRRC41 RNF144B KIFAP3 GAN NEDD4 RNF138 UBE2N RNF130 KLHL2 KIF20A KLHL3 UBE2G1 UBE2G2 KLHL9 SPSB2 SPSB1 KLC1 KBTBD6 KLC4 KLHL5 RLIM KLC3 KLC2 TRIP12 KBTBD8 KIF3B SPSB4 KIF3C UBE2D4 UBE3C MYLIP UBE3D FBXO27 KIF4B LTN1 KIF4A RNF19B KIF11 UBE3A UBE3B FBXO21 UBE2Z FBXO22 KIF15 PARK2 NPEPPS CAPZB RNF19A FBXW12 AREL1 FBXW8 UBE2E3 FBXO17 UBE2E2 FBXO15 MIB2 UBE4A KIF23 LMO7 FBXO10 KIF22 FBXO11 KLHL41 TRAIP KLHL42 BTRC KCTD7 CUL5 SKP1 BTK UBA6 TRAF6 UBA5 RBX1 SEC22B KLHL11 UBR2 PTEN TAB2 KLHL13 MAP3K7 UBR1 FBXO44 DCTN6 FBXO41 FBXO40 DCTN5 NUCLEAR IMPORT OF REV PROTEIN%REACTOME%R-HSA-180746.1 Nuclear import of Rev protein NUP85 TPR NUP88 NUP43 RCC1 RAE1 RANBP2 NUP107 NUP155 NUP188 NUP153 RAN NUP62 NUP35 NUPL2 NDC1 NPM1 NUP214 SEC13 NUP37 NUP133 NUP210 NUP93 NUP50 NUP54 KPNB1 POM121 NUP205 AAAS NUP160 REGULATION OF FZD BY UBIQUITINATION%REACTOME%R-HSA-4641263.2 Regulation of FZD by ubiquitination UBB FZD5 UBC RSPO2 RSPO3 RSPO1 RPS27A UBA52 RSPO4 RNF43 ZNRF3 WNT3A FZD4 FZD6 LRP5 FZD8 USP8 LRP6 LGR6 LGR5 LGR4 THE IPAF INFLAMMASOME%REACTOME%R-HSA-844623.1 The IPAF inflammasome CASP1 NLRC4 NEUROFASCIN INTERACTIONS%REACTOME DATABASE ID RELEASE 72%447043 Neurofascin interactions NFASC SDCBP CNTNAP1 CNTN1 DCX ANK1 NRCAM CENTROSOME MATURATION%REACTOME DATABASE ID RELEASE 72%380287 Centrosome maturation HAUS7 CEP70 PRKAR2B CEP72 CEP192 PCNT CEP76 YWHAG CLASP1 CEP78 PLK4 DYNC1H1 ODF2 CEP152 NDE1 NEDD1 FGFR1OP CEP41 OFD1 PPP2R1A PRKACA PLK1 CENPJ CDK1 TUBA4A CEP57 CETN2 TUBA1A CEP164 CCP110 ACTR1A PCM1 HSP90AA1 CNTRL CEP250 NEK2 NINL CEP290 CDK5RAP2 CEP135 TUBB CEP131 HAUS4 TUBGCP2 HAUS3 TUBGCP5 HAUS6 TUBGCP6 CSNK1D TUBGCP3 HAUS5 TUBGCP4 CSNK1E TUBG2 TUBG1 DYNLL1 MZT2B CKAP5 MZT2A HAUS2 NME7 HAUS1 AKAP9 CDK11A CEP63 MAPRE1 MZT1 YWHAE SFI1 TUBB4B PAFAH1B1 TUBB4A SDCCAG8 DYNC1I2 DCTN2 SSNA1 DCTN3 HAUS8 ERYTHROPOIETIN ACTIVATES STAT5%REACTOME%R-HSA-9027283.1 Erythropoietin activates STAT5 EPO JAK2 LYN STAT5A STAT5B IRS2 EPOR MET RECEPTOR ACTIVATION%REACTOME DATABASE ID RELEASE 72%6806942 MET Receptor Activation HPN HGF SPINT2 MET HGFAC SPINT1 AUTOPHAGY%REACTOME%R-HSA-9612973.1 Autophagy DYNC1LI1 DYNC1LI2 PRKAA1 PRKAA2 CSNK2A1 CSNK2A2 PIK3R4 PARK7 CSNK2B HBB DYNLL2 EEF1A1 MTMR14 PRKAB2 PRKAB1 RRAGA DYNC1I1 RRAGC MTMR3 RRAGB RRAGD CHMP2A UBE2V1 HSF1 TOMM20 TOMM22 ATG3 GABARAPL2 GABARAPL1 ATG9B ATG9A ATG10 ATG14 RNASE1 ATG13 ULK1 GABARAP ATG101 UVRAG ATM MTERF3 GFAP ATG16L1 CETN1 DYNLL1 WDR45 MAP1LC3B MAP1LC3A MAP1LC3C FUNDC1 RB1CC1 USP30 WIPI2 PRKAG1 PEX5 MLST8 ATG4C PRKAG2 ATG4B ATG4A DYNC1I2 ATG4D PRKAG3 BECN1 TOMM40 WDR45B RPTOR AMBRA1 MFN1 MFN2 TOMM70A NBR1 TSG101 PCNT TOMM7 TOMM5 TOMM6 MVB12B MVB12A DYNC1H1 VPS37C VPS37D VPS37A VPS37B CHMP2B CHMP4C UBAP1 CHMP4B UBA52 CHMP3 CHMP4A CHMP6 CHMP7 VPS28 ATG7 MTOR LAMTOR2 UBB LAMTOR1 LAMTOR4 LAMTOR3 UBC LAMTOR5 RPS27A HSPA8 VDAC1 TSC2 TSC1 HSP90AB1 UBE2N EPAS1 SLC38A9 HSP90AA1 ATG12 PIK3C3 ATG5 PLIN3 PARK2 PLIN2 HDAC6 RHEB LAMP2 WIPI1 CFTR VCP IFT88 SQSTM1 ARL13B PINK1 DEFECTIVE ALG14 CAUSES CONGENITAL MYASTHENIC SYNDROME (ALG14-CMS)%REACTOME%R-HSA-5633231.2 Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS) ALG14 ALG13 G2 M CHECKPOINTS%REACTOME DATABASE ID RELEASE 72%69481 G2 M Checkpoints EXO1 WHSC1 RPA1 RPA2 GTSE1 TOPBP1 WRN YWHAG RPA3 YWHAH DNA2 RFC5 RFC3 RFC4 RFC2 RNF8 RBBP8 BRE HIST3H3 MDC1 KAT5 RAD50 CHEK2 CHEK1 HUS1 TP53 RHNO1 BRIP1 SFN ATRIP BARD1 RAD17 ATM ATR YWHAB PSMD8 PSMD9 PSMD6 BRCA1 PSMD7 PSMD4 PSMD5 PSMD2 CCNB2 SUMO1 PSMD3 HERC2 PSMD1 YWHAZ RMI2 PSMA5 PSMA6 PSMA3 RMI1 PSMA4 TOP3A PSMA1 PSMA2 PIAS4 PSME3 PSME4 PSME1 PSME2 UBA52 BRCC3 PSMD10 PSMB11 PSMD12 TP53BP1 HIST3H2BB PSMD11 PSMD14 PSMD13 PSMA7 MRE11A PSMB10 HIST1H2BF PSMA8 HIST1H2BE HIST1H2BH HIST1H2BG PSMB6 HIST1H2BB PSMB7 HIST1H2BA PSMB4 HIST1H2BD HIST1H2BC PSMB5 PSMB2 CCNB1 UBB RAD1 BABAM1 PSMB3 UIMC1 UBC CDK1 PSMB1 PSMF1 RPS27A RNF168 SHFM1 NBN HIST1H4K PSMB8 PSMB9 HIST1H4L PSMC5 CDC25A PSMC6 PSMC3 ORC5 H2BFS PSMC4 ORC4 HIST1H4A PSMC1 ORC6 PSMC2 ORC1 HIST1H4B CDC25C ORC3 HIST1H4H ORC2 HIST1H4I HIST1H4J CDC7 HIST1H4C CDC6 HIST1H4D HIST1H4E UBE2N MCM7 HIST1H4F MCM8 MCM10 DBF4 MCM3 MCM4 PKMYT1 MCM5 MCM6 MCM2 CDC45 UBE2V2 WEE1 H2AFX HIST2H2BE CLSPN HIST4H4 CDK2 HIST1H2BN HIST1H2BM RAD9B HIST1H2BO RAD9A HIST1H2BJ YWHAE FAM175A HIST1H2BI HIST1H2BL HIST1H2BK HIST2H4A YWHAQ BLM HIST2H4B PHOSPHOLIPASE C-MEDIATED CASCADE; FGFR4%REACTOME DATABASE ID RELEASE 72%5654228 Phospholipase C-mediated cascade; FGFR4 FGF16 KLB FGF18 FGF19 FGFR4 FGF6 FGF9 PLCG1 FGF20 FGF1 FGF2 FGF23 FGF4 G2 M DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 72%69473 G2 M DNA damage checkpoint EXO1 WHSC1 HERC2 RPA1 RPA2 TOPBP1 WRN YWHAG RPA3 YWHAZ YWHAH RMI2 RFC5 DNA2 RFC3 RMI1 RFC4 TOP3A RFC2 PIAS4 RNF8 BRCC3 TP53BP1 HIST3H2BB MRE11A HIST1H2BF HIST1H2BE HIST1H2BH HIST1H2BG HIST1H2BB HIST1H2BA RBBP8 BRE HIST1H2BD HIST1H2BC CCNB1 HIST3H3 RAD1 BABAM1 UIMC1 MDC1 CDK1 KAT5 RNF168 RAD50 CHEK2 CHEK1 NBN HIST1H4K HIST1H4L H2BFS HUS1 HIST1H4A HIST1H4B CDC25C HIST1H4H HIST1H4I HIST1H4J HIST1H4C HIST1H4D HIST1H4E UBE2N TP53 HIST1H4F RHNO1 BRIP1 SFN ATRIP BARD1 UBE2V2 WEE1 H2AFX HIST2H2BE RAD17 ATM HIST4H4 ATR HIST1H2BN HIST1H2BM RAD9B YWHAB HIST1H2BO HIST1H2BJ RAD9A YWHAE HIST1H2BI FAM175A HIST1H2BL BRCA1 HIST1H2BK HIST2H4A YWHAQ SUMO1 BLM HIST2H4B LXRS REGULATE GENE EXPRESSION LINKED TO TRIGLYCERIDE LIPOLYSIS IN ADIPOSE%REACTOME%R-HSA-9031528.1 LXRs regulate gene expression linked to triglyceride lipolysis in adipose NR1H2 PLIN1 RXRB RXRA NR1H3 SIGNALING BY HEDGEHOG%REACTOME DATABASE ID RELEASE 72%5358351 Signaling by Hedgehog INTU CUL1 OS9 PRKAR2B KIF3A PRKAR2A TTC21B PTCH1 IFT122 FUZ ADCY10 GNAS SYVN1 MKS1 GLI1 GLI3 GLI2 IFT52 SUFU IFT57 OFD1 IFT140 KIF7 WDR35 NUMB ADCY4 ADCY3 PRKACG TULP3 ADCY2 PRKACA ADCY1 PRKACB ADCY8 ADCY7 ARRB1 ADCY6 ADCY5 CSNK1A1 WDR19 ITCH ADAM17 CDON CUL3 GPC5 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 ARRB2 PSME4 PSME1 PSME2 UBA52 HHIP PSMD10 DISP2 PSMB11 ULK3 PSMD12 HHAT SCUBE2 PSMD11 DZIP1 SHH PSMD14 DHH EFCAB7 IHH BOC PSMD13 IQCE EVC SPOPL PSMA7 GAS1 PSMB10 GAS8 PSMA8 ADRBK1 SPOP EVC2 PSMB6 NOTUM SMURF2 PSMB7 PSMB4 PSMB5 PSMB2 UBB PSMB3 UBC PSMB1 PSMF1 RPS27A SHFM1 PSMB8 PSMB9 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 GSK3B ERLEC1 CDC73 SMURF1 P4HB IFT172 BTRC SKP1 DYNC2H1 VCP RPGRIP1L RBX1 IFT88 ADCY9 SEL1L PRKAR1B SMO DERL2 PRKAR1A GPR161 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING%REACTOME DATABASE ID RELEASE 72%936440 Negative regulators of RIG-I MDA5 signaling ISG15 CYLD TNFAIP3 UBA52 UBE2K OTUD5 ATG12 RNF125 NLRX1 NLRC5 IKBKE RNF216 PCBP2 ATG5 ITCH IFIH1 TAX1BP1 RNF135 TBK1 MAVS UBE2D1 UBE2L6 HERC5 UBB TRIM25 UBC PIN1 RPS27A DDX58 IRF3 UBE2D2 TRAF3 UBE2D3 UBA7 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION%REACTOME%R-HSA-2151209.1 Activation of PPARGC1A (PGC-1alpha) by phosphorylation PRKAB1 MAPK14 MAPK11 PRKAG1 MAPK12 PRKAG2 PRKAG3 PRKAA2 PRKAB2 PPARGC1A G2 M DNA REPLICATION CHECKPOINT%REACTOME%R-HSA-69478.2 G2 M DNA replication checkpoint CDK1 PKMYT1 CCNB1 CCNB2 WEE1 RAF MAP KINASE CASCADE%REACTOME%R-HSA-5673001.8 RAF MAP kinase cascade CAMK2D CAMK2A RANBP9 CAMK2G RASGRF2 PPP2R5C DLG1 DLG4 RASGRP1 RASGRP3 ARRB1 IL2RG JAK3 DUSP5 DUSP2 DUSP1 DUSP8 DUSP9 DUSP16 DUSP10 PEA15 IQGAP1 SPRED3 PHB SPRED2 SPRED1 SYNGAP1 HRAS RASA3 RASA4 RASA1 RASA2 CUL3 BTC RASAL1 EPGN RASAL2 TGFA RASAL3 AREG NRAS HBEGF DAB2IP EREG NF1 KBTBD7 PDGFRB KIT PDGFB SPTAN1 PPP5C FGB FGA VWF FGG IRS1 IRS2 WDR83 PAQR3 BRAP RET GFRA3 IL17RD RAPGEF2 IL5RA SHC3 RASGRP4 IL5 MAP3K11 RASGEF1A IL3RA IL2RB NRTN GFRA1 SPTB EGF GFRA2 SHC1 GFRA4 SPTBN4 SPTBN5 EGFR SPTA1 SOS1 SPTBN1 SPTBN2 PSPN GDNF PTPRA ARTN TLN1 MAP2K1 MAP2K2 BRAF RAF1 JAK2 ACTN2 FGF6 FGF9 PPP2R1B PPP2R1A FGF20 FGF1 FGF2 FGF23 FGF3 FGF22 FGF10 FGF4 PPP2R5D GRIN2B GRIN2D CSF2RB CSF2RA PPP2CA PPP2CB NEFL LRRC7 GRIN1 ITGB3 YWHAB PSMD8 PSMD9 PSMD6 SRC PSMD7 PSMD4 PSMD5 IL3 CSK PSMD2 PPP2R5E PSMD3 NCAM1 PSMD1 PPP2R5B PPP2R5A PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 ITGA2B SHC2 ARAF PSMA2 PEBP1 PSME3 ARRB2 PSME4 DLG2 PSME1 PSME2 DLG3 KSR1 UBA52 RASGRF1 KSR2 PSMD10 APBB1IP PSMB11 CNKSR2 PSMD12 CNKSR1 PSMD11 PSMD14 VCL FYN PSMD13 PSMA7 PSMB10 PSMA8 RAP1B MARK3 FN1 PSMB6 DUSP4 PSMB7 PTK2 HGF PSMB4 MET RAP1A PSMB5 PSMB2 LAMTOR2 KLB CSF2 UBB FLT3 PSMB3 DUSP6 LAMTOR3 FLT3LG DUSP7 UBC PSMB1 PSMF1 IL2 FGF19 FGFR4 JAK1 RPS27A IL2RA SHFM1 PSMB8 PSMB9 PSMC5 MAPK1 PSMC6 PSMC3 MAPK3 PSMC4 PSMC1 PSMC2 NRG1 NRG2 FRS2 FRS3 FGF16 NRG3 FGF7 NRG4 FGF18 PDGFRA ERBB2 ANGPT1 RBX1 TEK CAMK2B STAT5 ACTIVATION%REACTOME%R-HSA-9645135.2 STAT5 Activation FLT3LG GAB2 PTPN11 STAT5A STAT5B FLT3 SUMOYLATION OF INTRACELLULAR RECEPTORS%REACTOME DATABASE ID RELEASE 72%4090294 SUMOylation of intracellular receptors SUMO2 NR3C1 VDR RARA HDAC4 AR THRB NR2C1 RXRA PPARG NR4A2 NR5A1 PPARA UBE2I RORA ESR1 PIAS4 PIAS3 NR1H2 PGR PIAS1 NR3C2 SUMO1 SUMO3 ENZYMATIC DEGRADATION OF DOPAMINE BY MONOAMINE OXIDASE%REACTOME DATABASE ID RELEASE 72%379398 Enzymatic degradation of Dopamine by monoamine oxidase MAOA COMT SIGNALING BY INTERLEUKINS%REACTOME%R-HSA-449147.11 Signaling by Interleukins CUL1 CASP1 CXCL2 CAPZA1 CCR2 CCL11 CCL3L1 CCL3L3 BIRC5 APP CCL5 CCL4 CCL3 CCL2 CCL19 CCR1 CCL22 IRAK3 CCL20 VAMP7 CXCL10 SIGIRR STX4 FOXO1 CD86 LCK CD80 FOXO3 BCL2L1 BCL2 PPIA ARF1 RPLP0 HSPA9 PTGS2 SOD2 F13A1 NFKBIA IKBKG IL21 IL21R SOX2 STAT5A STAT5B SOCS3 IRS1 RORA IRS2 PRTN3 MYC PIK3CD SHC1 PIK3R1 CBL PIK3CA SOS1 TCP1 TGFB1 STAT3 VEGFA IL7R SMARCA4 CXCL8 SOD1 JAK2 PPP2R1B PPP2R1A FGF2 TEC PRKACA RELA TNFRSF1B PPP2R5D PIK3R3 BLNK CTSG CCND1 PPP2CA PPP2CB NFKB1 NFKB2 GSTO1 CD36 BRWD1 ICAM1 IRF4 PIK3CB GATA3 POU2F1 PTAFR VAV1 CFL1 MAPKAPK3 CRK VCAM1 CCR5 PIK3R2 CDC42 ATF1 PTK2B ATF2 FYN ELK1 RPS6KA3 PAK2 RPS6KA5 RPS6KA2 RPS6KA1 JUNB DUSP4 MEF2A HGF MEF2C DUSP3 CRKL FOS IL1RAPL1 VRK3 DUSP6 DUSP7 CREB1 MAPKAPK2 MAPK7 MAPK1 MAPK3 MAPK14 MAPK11 STAT2 FASLG HSP90AA1 TNF ITGB1 TALDO1 LBP RAPGEF1 LAMA5 PTPN2 CANX CASP3 IL23R IL27 IL27RA IL12B SDC1 IL12A SERPINB2 IGHG4 IL23A BOLA2 SNRPA1 IGHG1 LCP1 TNFRSF1A RALA EBI3 BOLA2B HNRNPDL STAT4 IL12RB1 IL12RB2 SOS2 MSN HNRNPF HNRNPA2B1 PDCD4 IL2RG SOCS2 JAK3 TSLP CISH IL7 CRLF2 LYN LMNB1 YES1 INPPL1 IL6 ANXA1 ANXA2 IL10 SYK AIP HCK IL4 IL18RAP IL37 FBXW11 IL13 IL18R1 IL18BP SOCS1 IFNG HSP90B1 PITPNA CA1 IL18 IL1A IL1B HIST2H3A PTPN13 HIST2H3D HIST2H3C MTAP HIST1H3J HIST1H3A HIST1H3F VIM HIST1H3G HIST1H3H HIST1H3I HIST1H3B HIST1H3C HIST1H3D HIST1H3E IL5RA FPR1 IL5 HMOX1 IL3RA IL2RB MAOA INPP5D TBK1 MUC1 ALOX5 STAT6 ITGAM MAP2K1 ITGB2 ITGAX IL20RA IL20RB IL22RA2 IL22RA1 TIMP1 HAVCR2 ZEB1 STX3 IL10RB IL10RA CSF3 CSF3R CSF1 MAPK8 RORC PIM1 IL13RA2 IL13RA1 TXLNA FSCN1 IL1RN CSF1R IL36A NDN IL36B SOCS5 IL1R1 MCL1 IL1R2 CEBPD MIF IL36RN PTPRZ1 IL36G CD4 LGALS9 IL1F10 TOLLIP IL15RA PTPN20 STXBP2 PTPN23 TWIST1 IFNLR1 IL1RL1 GRB2 IL1RL2 IL22 MAP3K3 IL20 IL33 PTPN18 IL25 PTPN14 IL26 CSF2RB PTPN9 IL24 PTPN7 IL15 CSF2RA PTPN4 IL19 PTPN5 IL16 IL17RE IL17RC IL17RB IL17RA IGHE OPRD1 IL32 IL34 BATF IL17F IL17C IL17A IL4R IL9 MMP1 MMP2 MMP3 HMGB1 OPRM1 IKBKB IL9R FCER2 NKIRAS1 IFNL2 NKIRAS2 IFNL1 MAP3K8 S1PR1 MAP2K3 CHUK IFNL3 MAP2K4 RIPK2 IRAK4 PELI1 TP53 UBE2V1 PELI3 PELI2 NOD1 NOD2 AGER MAPK9 IRAK1 S100A12 MAP2K7 LCN2 S100B MAPK10 POMC TNIP2 JUN SAA1 MYD88 NFKBIB NOS2 CNN2 CDKN1A CXCL1 PSMD8 PSMD9 PSMD6 PSMD7 MMP9 PSMD4 PSMD5 SNAP25 IL3 PSMD2 PSMD3 AKT1 PSMD1 PTPN12 PTPN11 YWHAZ PSMA5 PSMA6 PSMA3 PSMA4 NANOG PSMA1 STX1A PSMA2 VAMP2 PSME3 PSME4 PTPN6 PSME1 PSME2 UBA52 SMAD3 RHOU PSMD10 PSMB11 PSMD12 PSMD11 COL1A2 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 RAP1B FN1 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 CSF2 UBB PSMB3 UBC PSMB1 GAB2 PSMF1 IL2 JAK1 RPS27A IL2RA HSPA8 SHFM1 RAG2 RAG1 PSMB8 PSMB9 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 STAT1 UBE2N HIF1A GSTA2 MAP2K6 BCL6 IL11 ALOX15 CNTFR CNTF IL31 CTF1 IL11RA LIF OSM IL31RA LIFR TYK2 P4HB OSMR CLCF1 IL6ST IL6R CRLF1 BTRC SKP1 IRAK2 TRAF6 RBX1 TAB3 SQSTM1 TAB2 TAB1 MAP3K7 DEFECTIVE ACY1 CAUSES ENCEPHALOPATHY%REACTOME DATABASE ID RELEASE 72%5579007 Defective ACY1 causes encephalopathy ACY1 APOPTOTIC FACTOR-MEDIATED RESPONSE%REACTOME DATABASE ID RELEASE 72%111471 Apoptotic factor-mediated response APIP BAK1 CARD8 CASP9 APAF1 XIAP CYCS CASP7 CASP3 BAX AVEN MAPK1 DIABLO CDKN2A UACA C1QBP MAPK3 DEFECTIVE BASE EXCISION REPAIR ASSOCIATED WITH NTHL1%REACTOME%R-HSA-9616333.2 Defective Base Excision Repair Associated with NTHL1 NTHL1 DEFECTIVE SLC5A5 CAUSES THYROID DYSHORMONOGENESIS 1 (TDH1)%REACTOME%R-HSA-5619096.1 Defective SLC5A5 causes thyroid dyshormonogenesis 1 (TDH1) SLC5A5 LRR FLII-INTERACTING PROTEIN 1 (LRRFIP1) ACTIVATES TYPE I IFN PRODUCTION%REACTOME%R-HSA-3134973.1 LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production EP300 LRRFIP1 IRF3 CTNNB1 CREBBP FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF)%REACTOME%R-HSA-2559584.1 Formation of Senescence-Associated Heterochromatin Foci (SAHF) HMGA2 LMNB1 ASF1A CABIN1 H1F0 TP53 EP400 HMGA1 HIRA HIST1H1D HIST1H1E RB1 HIST1H1A UBN1 HIST1H1B HIST1H1C BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN%REACTOME DATABASE ID RELEASE 72%446193 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein NEU2 NEU3 NEU1 DPM1 DPM2 DPM3 SLC35A1 SLC35C1 CTSA ST3GAL4 SRD5A3 ST3GAL6 ST3GAL1 MVD ST3GAL2 ST3GAL3 GLB1 ST6GALNAC1 GMPPB ST6GALNAC2 FPGT CMAS GMPPA PGM3 NPL NANP GNPNAT1 ST6GALNAC6 NUDT14 NEU4 ALG5 ST8SIA4 ALG10 SLC17A5 DPAGT1 RENBP ST8SIA5 MPI ALG10B ST3GAL5 ALG8 TSTA3 ST8SIA6 NANS ALG9 UAP1 ST6GAL1 ALG6 FUOM ST6GAL2 ALG14 GMDS ALG3 AMDHD2 ST8SIA1 ALG2 ALG13 FUK ST8SIA2 ALG12 PMM1 ST8SIA3 ALG1 ST6GALNAC3 GFPT2 ALG11 ST6GALNAC4 NAGK DHDDS ST6GALNAC5 DOLPP1 GNE MPDU1 GFPT1 NUS1 PMM2 DOLK RFT1 EGFR TRANSACTIVATION BY GASTRIN%REACTOME DATABASE ID RELEASE 72%2179392 EGFR Transactivation by Gastrin MMP3 HRAS EGFR PRKCA SOS1 NRAS HBEGF VEGF LIGAND-RECEPTOR INTERACTIONS%REACTOME DATABASE ID RELEASE 72%194313 VEGF ligand-receptor interactions FIGF FLT1 VEGFB VEGFC PGF VEGFA KDR FLT4 SIGNAL AMPLIFICATION%REACTOME%R-HSA-392518.1 Signal amplification GNG11 GNG13 MAPK14 GNB2 GNB1 GNB4 P2RY1 GNB3 GNB5 GNGT1 GNGT2 GNA14 GNA15 GNA11 TBXA2R PLA2G4A GNAI3 GNAT3 GNAI1 GNAI2 GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 GNAQ GNA13 GNG10 P2RY12 AAMP GNG12 BIOSYNTHESIS OF SPECIALIZED PRORESOLVING MEDIATORS (SPMS)%REACTOME DATABASE ID RELEASE 72%9018678 Biosynthesis of specialized proresolving mediators (SPMs) EPHX2 CYP3A4 ALOX15 PTGR1 ALOX12 CYP2C9 LTA4H CYP2C8 CYP2D6 GSTM4 HPGD ALOX5 PTGS2 LTC4S CYP1A2 CYP1A1 ALOX5AP CYP2E1 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS%REACTOME%R-HSA-418038.1 Nucleotide-like (purinergic) receptors ADORA2A P2RY13 ADORA2B P2RY10 P2RY14 LPAR4 P2RY1 P2RY6 P2RY4 LPAR6 ADORA3 P2RY2 ADORA1 P2RY11 P2RY12 GPR17 REGULATION OF PTEN GENE TRANSCRIPTION%REACTOME DATABASE ID RELEASE 72%8943724 Regulation of PTEN gene transcription RBBP4 CBX6 SALL4 RBBP7 MTA2 MTA3 MECOM MBD3 SUZ12 ATN1 NR2E1 MAF1 SNAI1 SNAI2 GATAD2B ATF2 GATAD2A CHD4 MTOR KDM1A BMI1 RNF2 LAMTOR2 CBX8 LAMTOR1 PHC2 LAMTOR4 PHC1 LAMTOR3 RING1 LAMTOR5 CBX4 CBX2 PHC3 MAPK1 MAPK3 EGR1 RRAGA RRAGC RRAGB REST RRAGD EZH2 TP53 CHD3 SLC38A9 JUN EED HDAC3 HDAC5 PPARG HDAC7 RHEB HDAC2 HDAC1 MLST8 RPTOR MTA1 VITAMIN C (ASCORBATE) METABOLISM%REACTOME DATABASE ID RELEASE 72%196836 Vitamin C (ascorbate) metabolism GSTO2 GSTO1 SLC23A2 SLC2A1 CYB5R3 SLC23A1 CYB5A SLC2A3 BLOOD GROUP SYSTEMS BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 72%9033658 Blood group systems biosynthesis ST3GAL4 B3GALT4 ST3GAL6 B3GALT5 RHCE FUT10 ST3GAL3 FUT11 FUT2 B4GALNT2 FUT1 FUT4 FUT3 FUT6 FUT5 FUT7 RHD FUT9 B3GALT2 B3GALT1 ST6GALNAC6 PROGRESSIVE TRIMMING OF ALPHA-1,2-LINKED MANNOSE RESIDUES FROM MAN9 8 7GLCNAC2 TO PRODUCE MAN5GLCNAC2%REACTOME%R-HSA-964827.2 Progressive trimming of alpha-1,2-linked mannose residues from Man9 8 7GlcNAc2 to produce Man5GlcNAc2 MAN1A2 MAN1C1 MAN1A1 MITOTIC G1 PHASE AND G1 S TRANSITION%REACTOME DATABASE ID RELEASE 72%453279 Mitotic G1 phase and G1 S transition RBBP4 CUL1 RPA1 POLE RPA2 RPA3 JAK2 RBL2 CCNA2 CCNA1 TFDP1 RBL1 PPP2R1B TFDP2 PPP2R1A POLE4 E2F1 E2F4 POLE2 POLE3 CCND1 DHFR PPP2CA PPP2CB LYN E2F2 E2F3 CDK4 CDKN1A CDKN1B AKT2 PSMD8 AKT3 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 AKT1 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 CCND3 PSME3 CCNH CCND2 PSME1 CDK6 PSME2 RRM2 UBA52 PSMD10 PSMD12 PPP2R2A PSMD11 PSMD14 DYRK1A PSMD13 TOP2A CDKN1C CDKN2A PSMA7 PSMB10 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 CCNB1 UBB PSMB3 UBC CDK1 PSMB1 PSMF1 RPS27A RB1 SHFM1 GMNN TYMS MYC PSMB8 FBXO5 CDKN2D PSMB9 SKP2 CDKN2B PSMC5 CDC25A CDKN2C PSMC6 MAX PSMC3 ORC5 PSMC4 ORC4 PSMC1 ORC6 CDK7 PSMC2 ORC1 ORC3 ORC2 CDT1 CCNE2 CDC7 CDC6 MNAT1 CCNE1 POLA1 POLA2 LIN54 MCM7 MCM8 MCM10 CKS1B LIN52 DBF4 MCM3 MCM4 MCM5 PTK6 MCM6 MYBL2 MCM2 PRIM2 LIN37 PRIM1 LIN9 CDC45 E2F5 TK1 E2F6 CABLES1 PPP2R3B WEE1 RPA4 ABL1 CDK2 SKP1 HDAC1 PCNA MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF UNSATURATED FATTY ACIDS%REACTOME%R-HSA-77288.2 mitochondrial fatty acid beta-oxidation of unsaturated fatty acids HADHB DECR1 HADHA ECI1 ACADL ACADM RESPONSE OF MTB TO PHAGOCYTOSIS%REACTOME%R-HSA-9637690.1 Response of Mtb to phagocytosis TRIM27 PGK1 GSK3A DUSP16 SFPQ ATP6V1H UBB CTSG UBC ENO1 KPNA1 RNF213 RPS27A UBA52 HGS VPS33B KPNB1 RAB5A CORO1A RAB7A MAPK1 NOS2 MAPK3 SELENOCYSTEINE SYNTHESIS%REACTOME%R-HSA-2408557.2 Selenocysteine synthesis RPL26 RPL29 RPL10L RPS4X RPL10A RPL28 RPS3A RPL7A RPL23A FAU RPL41 RPS27L SECISBP2 RPL3L UBA52 RPL37A RPS26 RPS25 RPS28 RPS27 RPL36A RPS29 RPL35A RPS20 RPS21 RPS24 RPS23 RPL22L1 SARS RPS4Y2 RPL10 RPS4Y1 RPS27A RPL12 RPL13A RPL11 RPS3 RPL14 RPL13 RPS2 PSTK RPL15 RPL18 RPL17 RPL19 RPL27A RPL26L1 RPL4 RPL39L RPL5 RPL30 RPL3 RPL32 RPL31 RPS9 RPS7 RPL34 RPS8 RPL8 RPS5 RPL9 RPS6 RPL6 RPL7 RPSA RPL36 RPS15 EEFSEC RPS14 RPL35 RPS17 RPL38 RPS16 RPL37 RPL39 RPS19 RPS15A RPL18A RPL36AL RPS18 RPLP1 RPL21 RPL23 SEPSECS RPS11 RPL22 RPLP0 RPS10 RPS13 RPS12 RPLP2 RPL24 RPL27 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE%REACTOME%R-HSA-168176.1 Toll Like Receptor 5 (TLR5) Cascade CUL1 MAP2K1 MAPKAPK3 UBA52 MAPK8 PPP2R1B ATF1 PPP2R1A APP ATF2 NFKBIA IKBKG ELK1 RELA RPS6KA3 RPS6KA5 RPS6KA2 RPS6KA1 DUSP4 PPP2R5D MEF2A MEF2C DUSP3 FOS VRK3 UBB DUSP6 DUSP7 UBC CREB1 MAPKAPK2 RPS27A MAPK7 MAPK1 MAPK3 PPP2CA HMGB1 PPP2CB IKBKB NKIRAS1 NKIRAS2 MAPK14 MAP3K8 MAP2K3 CHUK MAPK11 MAP2K4 RIPK2 IRAK4 PELI1 UBE2N UBE2V1 PELI3 PELI2 NOD1 NFKB1 TLR10 NOD2 NFKB2 TLR5 AGER MAPK9 IRAK1 MAP2K6 S100A12 MAP2K7 MAP3K1 S100B MAPK10 TNIP2 JUN SAA1 MYD88 NFKBIB FBXW11 BTRC ECSIT SKP1 IRAK2 TRAF6 TAB3 TAB2 TAB1 MAP3K7 RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN WNT SIGNALING%REACTOME%R-HSA-8939256.1 RUNX1 regulates transcription of genes involved in WNT signaling RSPO3 CBFB AXIN1 ESR1 FOXP3 RUNX1 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE%REACTOME DATABASE ID RELEASE 72%168181 Toll Like Receptor 7 8 (TLR7 8) Cascade CUL1 MAP2K1 MAPKAPK3 UBA52 MAPK8 PPP2R1B ATF1 PPP2R1A APP ATF2 NFKBIA IKBKG ELK1 RELA RPS6KA3 RPS6KA5 RPS6KA2 RPS6KA1 DUSP4 PPP2R5D MEF2A MEF2C DUSP3 FOS VRK3 UBB DUSP6 DUSP7 UBC CREB1 MAPKAPK2 RPS27A MAPK7 MAPK1 MAPK3 PPP2CA HMGB1 PPP2CB IKBKB NKIRAS1 NKIRAS2 MAPK14 MAP3K8 MAP2K3 CHUK MAPK11 MAP2K4 RIPK2 IRAK4 PELI1 UBE2N TLR9 TLR8 TLR7 UBE2V1 PELI3 PELI2 NOD1 NFKB1 NOD2 NFKB2 AGER MAPK9 IRAK1 MAP2K6 S100A12 MAP2K7 MAP3K1 S100B MAPK10 TNIP2 JUN SAA1 MYD88 NFKBIB FBXW11 IRF7 BTRC ECSIT SKP1 IRAK2 TRAF6 TICAM2 TAB3 LY96 TAB2 TICAM1 TAB1 MAP3K7 CD14 TLR4 MINUS-STRAND DNA SYNTHESIS%REACTOME%R-HSA-164516.1 Minus-strand DNA synthesis PPIA STIMULI-SENSING CHANNELS%REACTOME DATABASE ID RELEASE 72%2672351 Stimuli-sensing channels ANO3 ANO1 SGK3 SGK2 STOML3 RAF1 CLCN3 CLCN2 CLCN1 BSND STOM ANO10 SLC17A3 MCOLN3 TRPA1 WWP1 MCOLN2 TPCN2 TPCN1 CLCN7 CLCN6 CLCN5 CLCN4 OSTM1 UNC79 MCOLN1 RYR1 RYR2 RYR3 CLIC2 TRPC1 TRDN ASPH TRPC7 TRPC6 SRI TRPC3 UBA52 FKBP1B UBB UBC RPS27A SGK1 BEST2 SLC9C1 BEST3 SLC9C2 BEST1 BEST4 TRPC4AP SLC9B1 SLC9B2 SCNN1G SCNN1D SCNN1B SCNN1A TTYH3 TTYH2 CLCNKB WNK4 NEDD4L CLCNKA NALCN TRPM1 TRPM2 ASIC4 ASIC5 CLCA2 CLCA1 TRPM7 TRPM8 ASIC2 TRPM5 ASIC3 TRPM6 CLCA4 TRPM3 ASIC1 TRPM4 TRPV2 TRPV3 TRPV1 TRPV6 WNK1 TRPV4 WNK2 TRPV5 WNK3 UNC80 TRPC5 TRPC4 TSC22D3 ANO8 ANO9 ANO6 ANO7 ANO4 ANO5 ANO2 ADRENOCEPTORS%REACTOME%R-HSA-390696.3 Adrenoceptors ADRA2C ADRA1D ADRA2A ADRA1B ADRB3 ADRA1A ADRB1 ADRB2 VARIANT SLC6A14 MAY CONFER SUSCEPTIBILITY TOWARDS OBESITY%REACTOME%R-HSA-5619094.1 Variant SLC6A14 may confer susceptibility towards obesity SLC6A14 DIGESTION OF DIETARY LIPID%REACTOME DATABASE ID RELEASE 72%192456 Digestion of dietary lipid PNLIP LIPF PNLIPRP1 CLPS PNLIPRP3 PD-1 SIGNALING%REACTOME DATABASE ID RELEASE 72%389948 PD-1 signaling CD4 HLA-DQA2 PTPN11 HLA-DQA1 HLA-DRB5 HLA-DPA1 HLA-DRB4 HLA-DPB1 CD3G HLA-DRA PTPN6 HLA-DRB3 TRAV19 HLA-DRB1 PDCD1LG2 CD3E CD274 CD3D PDCD1 HLA-DQB2 HLA-DQB1 CSK LCK INHIBITION OF TSC COMPLEX FORMATION BY PKB%REACTOME DATABASE ID RELEASE 72%165181 Inhibition of TSC complex formation by PKB TSC2 TSC1 AKT2 ACTIVATION OF CASPASES THROUGH APOPTOSOME-MEDIATED CLEAVAGE%REACTOME DATABASE ID RELEASE 72%111459 Activation of caspases through apoptosome-mediated cleavage CASP7 CASP3 CASP9 APAF1 XIAP CYCS SPHINGOLIPID METABOLISM%REACTOME%R-HSA-428157.4 Sphingolipid metabolism ESYT3 SPHK1 ESYT2 ESYT1 NEU2 NEU3 SUMF2 NEU1 SUMF1 B4GALNT1 GM2A UGCG CSNK1G2 FA2H ARSA ALDH3B2 ALDH3B1 GALC GLA GLTP PRKD3 PRKD2 PRKD1 KDSR OSBP ARSJ ASAH1 ASAH2 ARSK ARSH ARSI ORMDL2 ARSF ARSG ORMDL3 ARSD PPAP2B PPAP2A ARSE ORMDL1 ARSB CPTP PPAP2C CTSA ACER2 SPTSSB ACER1 SPTSSA ACER3 SMPD3 SMPD2 SGPL1 CERS3 SMPD4 CERS4 CERS5 SMPD1 CERS6 SPTLC1 SPTLC2 ENPP7 SPTLC3 GLB1 SPHK2 VAPA VAPB CERS1 CERS2 SGPP2 SGPP1 UGT8 GBA2 GBA B3GALNT1 PPM1L SGMS2 CERK DEGS1 DEGS2 HEXB STS SAMD8 HEXA PSAP GLB1L TELOMERE EXTENSION BY TELOMERASE%REACTOME%R-HSA-171319.2 Telomere Extension By Telomerase RTEL1 TINF2 TERF2IP WRAP53 RUVBL2 RUVBL1 TERF1 TERF2 DKC1 NHP2 PIF1 TERT ACD GAR1 POT1 NOP10 TNFR1-INDUCED PROAPOPTOTIC SIGNALING%REACTOME%R-HSA-5357786.2 TNFR1-induced proapoptotic signaling USP2 TNFRSF1A TNF CYLD USP4 OTUD7B CASP8 TRADD TNFAIP3 USP21 RIPK1 TRAF2 FADD EXTRACELLULAR MATRIX ORGANIZATION%REACTOME%R-HSA-1474244.2 Extracellular matrix organization SDC4 NCSTN LAMA5 SDC2 LAMA2 SDC3 CDH1 LAMA1 LAMA4 LAMA3 LAMB3 LAMB2 LAMB1 CASP3 SDC1 SPARC DMP1 CAPN15 LUM MUSK P3H2 P3H1 P3H3 OPTC KLK7 SERPINH1 GDF5 ELN MMP20 MMP24 CTSV SH3PXD2A ADAM17 TPSAB1 CTSS MMP10 CTSL MMP12 CTSK MMP11 CTSB MMP14 MMP13 HSPG2 MMP16 MMP15 MMP17 PXDN MATN1 MMP19 MATN4 MATN3 TNXB TMPRSS6 SPP1 JAM2 JAM3 DSPP ITGB5 LOXL3 PLOD3 CAST LOXL4 PLOD2 PLOD1 CAPNS1 LOXL1 CAPNS2 LOXL2 COMP CAPN2 CAPN8 CAPN1 EFEMP2 CAPN9 EFEMP1 CAPN6 IBSP CAPN7 FMOD TNN CAPN5 CAPN3 TNR ITGA1 PCOLCE ADAM19 LOX ADAM15 ADAM9 PPIB FBN2 FBN3 CD151 HTRA1 LTBP4 LTBP2 FBLN1 LTBP3 NID1 LTBP1 NID2 FBLN2 FBLN5 SCUBE3 SCUBE1 CRTAP TGFB2 TGFB3 BMP7 BMP4 BMP2 P4HA1 P4HA2 P4HA3 ITGA11 FBN1 COLGALT2 BMP10 ITGAE HAPLN1 ITGB8 BMP1 ITGB6 COLGALT1 TLL2 MMP7 TLL1 ASPN FURIN ITGAD ITGA8 ITGA7 PCOLCE2 LRP4 PLG PDGFB SPOCK3 CAPN13 MFAP5 CAPN14 MFAP4 CAPN11 CAPN12 MFAP1 CAPN10 MFAP3 MFAP2 A2M FGB PRSS1 FGA PLEC FGG ITGA5 ITGA9 PRSS2 KLKB1 ADAMTS4 ADAMTS5 DDR1 ADAMTS2 ITGB4 ADAMTS3 NTN4 TNC PDGFA ADAMTS1 DMD TRAPPC4 ACTN1 DAG1 ITGA6 MMP25 DDR2 TIMP2 ADAMTS8 ADAMTS9 THBS1 ADAMTS16 TGFB1 ADAMTS14 F11R ADAMTS18 ADAM8 ITGAM ITGB2 ITGAL ITGAX TIMP1 PHYKPL FGF2 CTSG CTSD PTPRS SERPINE1 MMP1 MMP2 CEACAM1 MMP3 CEACAM6 CEACAM8 CD47 TTR CMA1 ICAM1 CD44 VTN ITGB3 ELANE KDR MMP8 KLK2 ITGAV MMP9 AGRN CASK NCAM1 ADAM10 PRKCA ADAM12 COL17A1 COL18A1 COL15A1 COL16A1 COL13A1 VCAM1 COL14A1 COL11A1 ITGA2B COL11A2 COL12A1 COL19A1 COL10A1 COL28A1 COL26A1 COL27A1 COL24A1 COL25A1 COL22A1 COL23A1 COL1A1 COL3A1 COL2A1 COL1A2 COL4A2 COL5A1 COL4A1 COL6A2 COL7A1 COL4A4 COL5A3 COL5A2 FN1 COL6A1 COL4A3 COL8A2 COL4A6 COL9A1 COL20A1 COL21A1 COL6A3 COL4A5 COL8A1 COL9A3 COL6A6 COL9A2 COL6A5 NRXN1 ITGA10 ITGB7 ITGA4 ICAM2 ICAM3 ICAM4 ICAM5 BCAN VCAN NCAN P4HB ITGB1 BGN LAMC3 BSG LAMC2 CTRB2 CTRB1 DCN LAMC1 PSEN1 ITGA3 ITGA2 CELL DIVISION%REACTOME DATABASE ID RELEASE 72%68884 cell division PDS5B PDS5A RAD21 PLK1 STAG1 STAG2 KIF20A KIF23 MAU2 WAPAL NIPBL SMC1A SMC3 COPI-INDEPENDENT GOLGI-TO-ER RETROGRADE TRAFFIC%REACTOME%R-HSA-6811436.1 COPI-independent Golgi-to-ER retrograde traffic DCTN4 DYNC1I1 GALNT2 GALNT1 CAPZA3 DYNC1H1 CAPZA1 CAPZA2 RAB18 RAB3GAP2 ACTR10 RAB3GAP1 ACTR1A RAB6B DYNC1LI1 DYNC1LI2 DCTN1 BICD1 BICD2 RAB6A PLA2G4A CAPZB DYNLL1 AGPAT3 DYNLL2 PAFAH1B1 DYNC1I2 PLA2G6 PAFAH1B3 DCTN2 PAFAH1B2 DCTN6 DCTN3 DCTN5 DEFECTIVE SLC26A4 CAUSES PENDRED SYNDROME (PDS)%REACTOME DATABASE ID RELEASE 72%5619046 Defective SLC26A4 causes Pendred syndrome (PDS) SLC26A4 CHROMOSOME MAINTENANCE%REACTOME%R-HSA-73886.2 Chromosome Maintenance LIG1 RBBP4 RPA1 RPA2 POLD3 RFC1 POLD4 WRN RPA3 POLD1 POLD2 DNA2 RFC5 RFC3 TERF2IP RBBP7 RFC4 RFC2 DSCC1 CHTF18 CASC5 OBFC1 DKC1 NHP2 PIF1 CHTF8 TERT GAR1 CTC1 TEN1 NOP10 HIST3H3 RUVBL2 ITGB3BP CENPA CENPC CENPT CENPU CENPH CENPI CENPK CENPL CENPM CENPN CENPO CENPP CENPQ STRA13 RTEL1 TINF2 HIST1H2AE HIST1H2AD HIST3H2BB HIST1H2AC ACD HIST1H2AB HIST1H2AJ NPM1 HIST1H2BF HIST1H2BE HIST1H2BH HIST1H2BG HIST1H2BB HIST1H2BA HIST1H2BD HIST1H2BC H2AFB1 HJURP TERF1 RSF1 TERF2 MIS18BP1 OIP5 CENPW MIS18A HIST1H4K POT1 HIST1H4L SMARCA5 H2BFS HIST1H4A HIST1H4B HIST1H4H HIST1H4I HIST1H4J HIST1H4C APITD1 POLA1 HIST1H4D POLA2 HIST1H4E HIST1H4F HIST2H2AA3 WRAP53 HIST2H2AA4 RUVBL1 HIST2H2AC PRIM2 H2AFJ PRIM1 H2AFZ H2AFX H2AFV HIST2H2BE HIST4H4 HIST1H2BN HIST1H2BM HIST1H2BO HIST1H2BJ HIST1H2BI HIST1H2BL HIST1H2BK HIST2H4A FEN1 BLM HIST2H4B PCNA AXON GUIDANCE%REACTOME%R-HSA-422475.6 Axon guidance RPS4X PRKAR2A RPS3A NUMB CSNK2A1 CSNK2A2 SH3GL2 CSNK2B MYH14 MYH10 NCBP1 NCBP2 CLASP2 UNC5A UNC5B HRAS RASA1 NRAS RPLP1 RPLP0 RPLP2 RPS27L ABL2 CAP2 RPL22L1 IRS2 VASP ENAH EVL NTN4 HSP90AB1 PIK3CD SHC1 GAB1 PIK3R1 EGFR PIK3CA PLCG1 SOS1 ALCAM DPYSL4 DPYSL5 DPYSL2 DPYSL3 UNC5C UNC5D AGAP2 FLRT3 RDX PPP3CB LYPLA2 DSCAML1 ZSWIM8 FARP2 MSI1 RHOA PLXNC1 SEMA6A SEMA6D SEMA7A PLXNA2 PLXNA1 PLXNA3 DAB1 CLTCL1 LHX3 LHX2 PLXNB3 PLXNB1 LHX4 LHX9 SEMA3A SEMA3E ABLIM1 ABLIM2 ABLIM3 SEMA4A SEMA4D RPS6KA4 EPHA5 EPHA4 EPHA7 EPHA6 DNM1 EPHA8 ANK2 DNM3 HFE2 RPL23A ANK3 SHTN1 EZR EPHA3 EPHA2 EPHA10 RPS6KA6 RRAS NRP2 RGMB RGMA RELN PAK7 KCNQ2 PAK6 KCNQ3 PAK4 CD72 DSCAM PRKACG PFN1 DOK4 DOK5 PRKACA DOK6 FES PRKACB ARHGEF28 EFNA5 EFNA4 EFNA1 EFNA3 EFNA2 USP33 EFNB2 RND1 EFNB1 GAP43 EFNB3 CRMP1 EPHB2 PDLIM7 GRIN2B EPHB1 PIK3R3 EPHB4 EPHB3 PIP5K1C SCN11A SCN9A SCN1B ISL1 SCN1A RPL27A CACNB1 SCN10A CACNB4 GIT1 SCN8A WASL NEO1 CACNA1S SCN3B SCN3A SCN2A SCN2B GRIN1 GPC1 CLTC ITGB3 CLTB CLTA AP2A1 SCN5A PIK3CB AP2B1 AP2A2 AP2S1 TREM2 AP2M1 TRPC1 PFN2 NCK2 ITGAV TYROBP RAC1 SCN4A CXCL12 NCK1 SCN4B AGRN VAV3 NCAM1 CFL1 VAV2 SCN7A LIMK2 DOCK1 LIMK1 ROCK1 ROCK2 CXCR4 DLG3 PIK3R2 CDC42 PAK1 FYN PAK3 RPS6KA3 PAK2 RPS6KA5 RPS6KA2 RPS6KA1 PTK2 MET MAPK12 MAPK13 DNM2 CREB1 MAPK7 MAPK1 EIF4A3 MAPK3 CASC3 MAGOH MAPK14 MAPK11 CDK5 RAP1GAP CDK5R1 RPL26L1 RPL4 RBM8A RPL5 HSP90AA1 RPL30 RPL3 ERBB2 RPL32 RPL31 RPL34 RPL8 RPL9 RPL6 RPL7 UPF3B MAGOHB RPL36 TRIO RNPS1 ITSN1 RPL35 RPL38 RPL37 RPL39 NCAN RPL21 RPL23 ITGB1 RPL22 GRB7 NGEF LAMC1 DOK2 PSEN2 PSEN1 KALRN RPL24 RPL27 ITGA2 APH1A RPL26 NCSTN RPL29 SDC2 APH1B AKAP5 LAMA1 RPL28 RANBP9 LAMB1 RPL41 DLG1 DLG4 RPL3L PSENEN ARHGEF11 ARHGEF12 SOS2 MSN CNTNAP1 DCX NRCAM RPL10 RPL12 RPL11 RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 LYN MYL12A MYL12B YES1 MYH11 ITGA1 MYL6 MYL9 RPS9 RPS7 RPS8 RPS5 CACNA1D RPS6 CACNA1C RPSA CACNB2 CACNB3 MYH9 DCC PITPNA NTN1 CLASP1 RPL7A ARPC1B ARPC1A MYO9B ACTG1 RPL37A ACTB SPTAN1 ARPC4 ARPC5 ARPC2 RPL36A ARPC3 ACTR3 RPL35A ACTR2 PRKCQ ROBO2 MYO10 NELL2 SLIT1 SLIT3 SLIT2 ROBO1 L1CAM ITGA5 ITGA9 RPS4Y2 RPS4Y1 RET GFRA3 SEMA5A SHC3 CUL2 DAG1 NRTN GFRA1 GSK3B SPTB GFRA2 GFRA4 SPTBN4 SPTBN5 CACNA1H CACNA1G SPTA1 RPL39L CACNA1I SPTBN1 SPTBN2 PRNP PSPN GDNF PTPRA ARTN CNTN2 ABL1 RPS15A HOXA2 TRPC5 TRPC4 PLXNA4 TLN1 PTPRC RPL10L RPL10A MAP2K1 MAP2K2 FAU NFASC MAPK8 RPL13A CAP1 MMP2 PLXND1 CNTN1 ARHGAP39 ST8SIA4 RPS15 SDCBP RPS14 RPS17 ST8SIA2 RPS16 RPS19 RPL18A SRGAP3 RPL36AL SRGAP1 RPS18 RPS11 RPS10 RPS13 PSMD8 PSMD9 RPS12 PSMD6 SH3KBP1 SRC PSMD7 MMP9 PSMD4 PSMD5 PSMD2 PSMD3 TRPC7 PSMD1 TRPC6 ADAM10 TRPC3 PRKCA PTPN11 PSMA5 PSMA6 ARHGEF7 PSMA3 PSMA4 PSMA1 ITGA2B EPHA1 PSMA2 PSME3 RHOC PSME4 PSME1 PSME2 RHOB PABPC1 UBA52 RPS26 TCEB2 PSMD10 TIAM1 TCEB1 PSMB11 RPS25 PSMD12 RPS28 GSPT2 PSMD11 GSPT1 RPS27 PSMD14 UPF3A COL4A2 PSMD13 RPS29 COL4A1 PSMA7 COL6A2 RPS20 PSMB10 PSMA8 RPS21 COL4A4 RPS24 UPF2 RPS23 PSMB6 COL6A1 ETF1 COL4A3 PSMB7 PSMB4 COL9A1 PSMB5 PSMB2 COL6A3 COL4A5 UBB PSMB3 GRB10 COL9A3 COL6A6 COL9A2 UBC PSMB1 GAB2 COL6A5 PSMF1 RPS27A LDB1 HSPA8 SHFM1 SIAH2 SIAH1 PSMB8 PSMB9 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 ARHGAP35 EIF4G1 FRS2 DOK1 NRP1 CNTN6 CHL1 ITGA10 ANK1 VLDLR KIF4B KIF4A RBX1 SIGNALING BY CYTOSOLIC FGFR1 FUSION MUTANTS%REACTOME DATABASE ID RELEASE 72%1839117 Signaling by cytosolic FGFR1 fusion mutants BCR STAT1 LRRFIP1 CUX1 STAT5A STAT5B CPSF6 ZMYM2 FGFR1OP2 MYO18A FGFR1OP GAB2 PIK3R1 TRIM24 PIK3CA STAT3 NUCLEAR ENVELOPE (NE) REASSEMBLY%REACTOME%R-HSA-2995410.3 Nuclear Envelope (NE) Reassembly TNPO1 VPS4A NUP107 NUP188 BANF1 CHMP2B CHMP4C CHMP4B CHMP3 CHMP4A CHMP6 PPP2R1A PPP2R2A NUP62 CHMP7 NDC1 SEC13 TUBB6 NUP133 TUBB3 TUBB1 NUP93 LBR CCNB1 NUP54 CDK1 TUBA4B ANKLE2 EMD TUBA4A VRK1 KPNB1 LEMD3 SIRT2 POM121 NUP205 NUP160 PPP2CA NUP85 LMNB1 NUP43 AHCTF1 RANGAP1 RCC1 CHMP2A NUP155 TUBA8 TUBA1C TUBA1B TUBA1A RAN TUBB8P12 TUBB8 TUBB2B TUBB2A SPAST LEMD2 NUP35 CC2D1B NUP37 TUBAL3 TUBA3E UBE2I IST1 TUBB4B TUBB4A SUMO1 CCNB2 IRF3-MEDIATED INDUCTION OF TYPE I IFN%REACTOME%R-HSA-3270619.1 IRF3-mediated induction of type I IFN DDX41 TBK1 TMEM173 NLRC3 PRKDC DTX4 IFI16 NLRP4 TREX1 IRF3 XRCC6 XRCC5 MRE11A MRNA EDITING%REACTOME%R-HSA-75072.3 mRNA Editing APOBEC3H ADAR A1CF APOBEC3A APOBEC3B ADARB1 APOBEC1 APOBEC3C APOBEC2 APOBEC4 BIOGENIC AMINES ARE OXIDATIVELY DEAMINATED TO ALDEHYDES BY MAOA AND MAOB%REACTOME DATABASE ID RELEASE 72%141333 Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB MAOB MAOA UNCOATING OF THE INFLUENZA VIRION%REACTOME%R-HSA-168336.3 Uncoating of the Influenza Virion TERMINATION OF O-GLYCAN BIOSYNTHESIS%REACTOME%R-HSA-977068.1 Termination of O-glycan biosynthesis ST3GAL4 ST3GAL1 MUC1 ST3GAL2 ST6GAL1 ST3GAL3 MUC7 MUC12 ST6GALNAC3 MUC20 MUC4 ST6GALNAC4 MUC13 MUC6 MUC15 MUC17 MUC5B MUC21 MUCL1 MUC3A MUC5AC ST6GALNAC2 MITOTIC ANAPHASE%REACTOME DATABASE ID RELEASE 72%68882 Mitotic Anaphase PPP2R5C ERCC6L ZWILCH BUB1B CASC5 SMC3 CDC20 PTTG1 KNTC1 DYNC1LI1 BIRC5 DYNC1LI2 CLIP1 ZW10 MAD1L1 CDCA5 CDCA8 PDS5B PDS5A PMF1 SKA1 AURKB SKA2 DSN1 RAD21 RCC2 NDC80 ZWINT STAG1 KIF18A STAG2 SGOL2 SGOL1 NUF2 WAPAL SPDL1 NDEL1 NUDC SMC1A DYNLL2 ESPL1 KIF2A INCENP KIF2C KIF2B ITGB3BP MIS12 CENPA NSL1 CENPC BUB3 BUB1 DYNC1I1 CLASP2 CENPT LMNB1 CENPU CENPE CENPF CENPH CENPI TAOK1 CENPK CENPL CHMP2A CENPM CENPN B9D2 CENPO CENPP CENPQ SPC24 MAD2L1 SPC25 UBE2I DYNLL1 CKAP5 MAPRE1 PAFAH1B1 DYNC1I2 CCNB2 CLASP1 DYNC1H1 NDE1 TUBB6 ANAPC15 ANAPC16 TUBB3 ANAPC7 TUBB1 UBE2C PLK1 UBE2E1 UBE2D1 ANAPC10 ANAPC11 CCNB1 CDC23 CDC26 CDC27 CDC16 CDK1 ANAPC4 TUBA4B ANAPC5 ANAPC1 TUBA4A ANAPC2 KPNB1 APITD1 TUBA8 TUBA1C TUBA1B TUBA1A TUBB2B TUBB2A TUBAL3 TUBA3E IST1 TUBB4B TUBB4A PPP1CC NUP107 NUP188 BANF1 PPP2R1B PPP2R1A NUP62 NDC1 SEC13 NUP133 PPP2R5D NUP93 LBR NUP54 ANKLE2 EMD VRK1 LEMD3 SIRT2 POM121 NUP205 NUP160 PPP2CA PPP2CB NUP85 NUP43 RANBP2 NUP155 NUP35 NUP37 PSMD8 PSMD9 PSMD6 XPO1 PSMD7 PSMD4 PSMD5 PSMD2 SUMO1 PPP2R5E PSMD3 PSMD1 TNPO1 PPP2R5B PPP2R5A VPS4A PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 CHMP2B PSME2 CHMP4C UBA52 CHMP4B CHMP3 CHMP4A PSMD10 CHMP6 PSMB11 PSMD12 PPP2R2A PSMD11 CHMP7 RPS27 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 UBB PSMB3 UBC PSMB1 PSMF1 RPS27A SHFM1 PSMB8 PSMB9 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 AHCTF1 RANGAP1 RCC1 RAN TUBB8P12 TUBB8 SPAST LEMD2 CC2D1B MISMATCH REPAIR (MMR) DIRECTED BY MSH2:MSH3 (MUTSBETA)%REACTOME%R-HSA-5358606.1 Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) LIG1 EXO1 RPA1 MLH1 RPA2 POLD3 POLD4 MSH2 RPA3 POLD1 POLD2 PMS2 MSH3 PCNA SYNTHESIS OF PS%REACTOME DATABASE ID RELEASE 72%1483101 Synthesis of PS PTDSS2 PTDSS1 SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 72%373755 Semaphorin interactions SEMA4D PTPRC CFL1 LIMK2 LIMK1 ROCK1 ROCK2 RHOC RRAS RHOB ARHGEF11 PAK1 CD72 ARHGEF12 FES FYN PAK3 PAK2 RND1 CRMP1 MET PIP5K1C MYH14 MYH10 SEMA5A ARHGAP35 PLXND1 MYL12B NRP1 HSP90AB1 CDK5 MYH11 GSK3B CDK5R1 ITGA1 HSP90AA1 MYL6 MYL9 ERBB2 DPYSL4 DPYSL5 DPYSL2 DPYSL3 MYH9 FARP2 RHOA PLXNC1 SEMA6A SEMA6D SEMA7A PLXNA2 PLXNA1 ITGB1 PLXNA3 PLXNB3 TREM2 PLXNB1 SEMA3A TYROBP SEMA3E PLXNA4 RAC1 TLN1 SEMA4A SIGNALING BY HIGH-KINASE ACTIVITY BRAF MUTANTS%REACTOME%R-HSA-6802948.1 Signaling by high-kinase activity BRAF mutants MAP2K1 MAP2K2 BRAF RAF1 ITGA2B ARAF PEBP1 IQGAP1 ARRB2 KSR1 KSR2 APBB1IP CNKSR2 CNKSR1 VCL ARRB1 RAP1B FGB MARK3 HRAS FGA FN1 VWF RAP1A FGG NRAS ITGB3 YWHAB SRC MAPK1 CSK MAPK3 TLN1 MISSPLICED GSK3BETA MUTANTS STABILIZE BETA-CATENIN%REACTOME%R-HSA-5339716.2 Misspliced GSK3beta mutants stabilize beta-catenin CSNK1A1 PPP2CA PPP2CB PPP2R5B PPP2R5A PPP2R5D CTNNB1 GSK3B PPP2R5C PPP2R1B PPP2R1A AMER1 AXIN1 APC PPP2R5E TRP CHANNELS%REACTOME DATABASE ID RELEASE 72%3295583 TRP channels TRPC7 TRPC6 TRPC3 TRPC4AP TRPM1 MCOLN3 TRPM2 TRPA1 MCOLN1 MCOLN2 TRPM7 TRPM8 TRPM5 TRPM6 TRPM3 TRPM4 TRPV2 TRPV3 TRPV1 TRPV6 TRPV4 TRPV5 TRPC5 TRPC4 TRPC1 ATF6 (ATF6-ALPHA) ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 72%381033 ATF6 (ATF6-alpha) activates chaperones MBTPS1 CALR MBTPS2 HSPA5 NFYA NFYB NFYC DDIT3 ATF6 HSP90B1 ATF4 DEFECTIVE TPR MAY CONFER SUSCEPTIBILITY TOWARDS THYROID PAPILLARY CARCINOMA (TPC)%REACTOME DATABASE ID RELEASE 72%5619107 Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) NUP85 TPR NUP88 NUP43 RAE1 RANBP2 GCKR NUP107 NUP155 NUP188 NUP153 GCK NUP62 NUP35 NUPL2 NDC1 NUP214 SEC13 NUP37 NUP133 NUP210 NUP93 NUP50 NUP54 POM121 NUP205 AAAS NUP160 GLUCOCORTICOID BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 72%194002 Glucocorticoid biosynthesis CYP21A2 SERPINA6 CYP17A1 HSD3B2 HSD3B1 HSD11B1 CYP11B2 HSD11B2 CYP11B1 POMC INHIBITION OF NITRIC OXIDE PRODUCTION%REACTOME%R-HSA-9636249.1 Inhibition of nitric oxide production KPNA1 KPNB1 NOS2 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME%REACTOME DATABASE ID RELEASE 72%975155 MyD88 dependent cascade initiated on endosome CUL1 MAP2K1 MAPKAPK3 UBA52 MAPK8 PPP2R1B ATF1 PPP2R1A APP ATF2 NFKBIA IKBKG ELK1 RELA RPS6KA3 RPS6KA5 RPS6KA2 RPS6KA1 DUSP4 PPP2R5D MEF2A MEF2C DUSP3 FOS VRK3 UBB DUSP6 DUSP7 UBC CREB1 MAPKAPK2 RPS27A MAPK7 MAPK1 MAPK3 PPP2CA HMGB1 PPP2CB IKBKB NKIRAS1 NKIRAS2 MAPK14 MAP3K8 MAP2K3 CHUK MAPK11 MAP2K4 RIPK2 IRAK4 PELI1 UBE2N TLR9 TLR8 TLR7 UBE2V1 PELI3 PELI2 NOD1 NFKB1 NOD2 NFKB2 AGER MAPK9 IRAK1 MAP2K6 S100A12 MAP2K7 MAP3K1 S100B MAPK10 TNIP2 JUN SAA1 MYD88 NFKBIB FBXW11 IRF7 BTRC ECSIT SKP1 IRAK2 TRAF6 TICAM2 TAB3 LY96 TAB2 TICAM1 TAB1 MAP3K7 CD14 TLR4 ACTIVATION OF PKB%REACTOME%R-HSA-165158.3 Activation of PKB PDPK1 AKT2 TRIB3 THEM4 DEFECTIVE MGAT2 CAUSES MGAT2-CDG (CDG-2A)%REACTOME DATABASE ID RELEASE 72%4793952 Defective MGAT2 causes MGAT2-CDG (CDG-2a) MGAT2 TRANSLATION%REACTOME%R-HSA-72766.4 Translation RPL26 MRPL39 MRPL36 RPL29 MRPL37 MRPL34 RPS4X RPL28 MRPL35 MRPL32 MRPL33 RPS3A MRPL4 MRPL41 MRPL3 MRPL42 MRPL2 MRPL1 MRPL40 MRPL9 CHCHD1 RPL41 MRPS28 TSFM MRPS26 RPL3L MRPS27 MRPS24 MRPS25 MRPS22 MRPS23 MRPL49 MRPS18B MRPS2 MRPS18A MRPL47 MRPL48 MRPL45 MRPS7 MRPL46 MRPS6 MRPS5 MRPL43 MRPS18C TUFM MRPL44 MRPL52 OXA1L MRPL53 MRPL50 MRPS9 MRPL51 AURKAIP1 DAP3 MRPS35 MRPS36 MRPL18 MRPS33 MRPL19 RPL10 MRPS34 MRPL16 RPL12 RPL11 MRPS31 MRPL17 MRPL14 MRPL15 RPS3 MRPS30 RPL14 MRPL12 RPL13 MRPL57 MRPL13 RPS2 MRPL10 RPL15 MRPL54 RPL18 MRPL55 RPL17 MRPL11 RPL19 MRPL20 ICT1 SEC61A2 GADD45GIP1 SEC61A1 PTCD3 MRPL27 SEC61G MRPL28 SEC61B ERAL1 MRPL23 MRPL24 MRPL21 MRPL22 MRPL30 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPLP1 RPLP0 TRMT112 RPLP2 RPL7A RPS27L RPL37A EIF1AX EIF2B5 RPL36A EIF2B4 EIF2B3 EIF2B2 EIF2S2 RPL35A EIF2S1 EIF5 EIF2S3 EIF2B1 EIF5B EIF4H EIF3M EIF3K RPL22L1 EIF3L EIF3I EIF3J EIF3G EIF3H EIF3E EIF3F EIF3C EIF3D EIF3A RPS4Y2 EIF3B RPS4Y1 RPL39L SRPR APEH SSR1 RPS15A SRPRB N6AMT1 RPL10L RPL10A RPL23A DDOST FAU CARS YARS DARS WARS VARS SARS TARS EPRS AIMP1 RPL13A NARS AIMP2 KARS QARS EEF1B2 LARS EEF1A1 PPA1 EEF1G RARS EEF1D MARS EEF1A2 GARS EEF2 HARS IARS FARSA EEF1E1 RPL27A FARSB AARS SEC11A SEC11C SPCS3 SPCS2 SPCS1 SRP14 PARS2 EARS2 LARS2 TARS2 AARS2 RPN2 RPN1 HARS2 TRAM1 GFM2 SRP54 RPS15 FARS2 RPS14 SSR4 RPS17 SSR2 RPS16 SSR3 SRP9 RPS19 MRRF RPL18A SRP72 RPL36AL SRP68 RPS18 SRP19 MTFMT YARS2 NARS2 RPS11 RARS2 RPS10 CARS2 RPS13 VARS2 MARS2 RPS12 DARS2 SARS2 MTRF1L MTIF2 MTIF3 IARS2 WARS2 PABPC1 UBA52 RPS26 RPS25 RPS28 GSPT2 GSPT1 RPS27 RPS29 RPS20 RPS21 RPS24 RPS23 ETF1 EIF4A2 EIF4A1 RPS27A EIF4G1 EIF4E RPL26L1 RPL4 RPL5 RPL30 RPL3 RPL32 EIF4EBP1 RPL31 EIF4B RPL34 RPL8 RPL9 RPL6 RPL7 RPL36 RPL35 RPL38 RPL37 RPL39 RPL21 RPL23 RPL22 MRPS17 MRPS15 GFM1 MRPS16 MRPS14 PPA2 MRPS11 RPL24 MRPS12 RPL27 MRPL38 MRPS10 INTESTINAL ABSORPTION%REACTOME DATABASE ID RELEASE 72%8963676 Intestinal absorption SLC5A1 SLC2A5 RSC1A1 SLC2A2 RA BIOSYNTHESIS PATHWAY%REACTOME DATABASE ID RELEASE 72%5365859 RA biosynthesis pathway CYP26C1 RDH11 CRABP1 DHRS3 ALDH1A1 ADH1C DHRS4 ALDH1A3 ADH1A SDR16C5 DHRS9 ALDH1A2 RDH10 AKR1C3 RDH16 RDH5 RDH14 RDH13 ALDH8A1 ADH4 CYP26A1 CYP26B1 ASPARTATE AND ASPARAGINE METABOLISM%REACTOME%R-HSA-8963693.1 Aspartate and asparagine metabolism GOT1 SLC25A12 GOT2 ASPG NAALAD2 NAT8L FOLH1 ASPA GADL1 SLC25A13 ASNS LXRS REGULATE GENE EXPRESSION TO LIMIT CHOLESTEROL UPTAKE%REACTOME%R-HSA-9031525.1 LXRs regulate gene expression to limit cholesterol uptake NR1H2 RXRB RXRA MYLIP NR1H3 ROBO RECEPTORS BIND AKAP5%REACTOME%R-HSA-9010642.1 ROBO receptors bind AKAP5 ROBO2 AKAP5 PRKAR2A PPP3CB PRKCA PRKACG PRKACA PRKACB COMMON PATHWAY OF FIBRIN CLOT FORMATION%REACTOME DATABASE ID RELEASE 72%140875 Common Pathway of Fibrin Clot Formation PF4V1 CD177 FGB FGA SERPIND1 F10 F2R FGG F2 F5 PROCR F8 PROC SERPINE2 SERPINC1 PROS1 F13B F13A1 PRTN3 PF4 SERPINA5 THBD TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 72%3642279 TGFBR2 MSI Frameshift Mutants in Cancer TGFB1 TGFBR2 UNBLOCKING OF NMDA RECEPTORS, GLUTAMATE BINDING AND ACTIVATION%REACTOME%R-HSA-438066.3 Unblocking of NMDA receptors, glutamate binding and activation GRIA2 CAMK2D CAMK2A NEFL GRIN2C GRIN2B GRIN2D GRIN1 CAMK2G GRIA3 LRRC7 GRIA4 DLG2 DLG1 ACTN2 DLG4 DLG3 GRIN2A GRIA1 CAMK2B SYNTHESIS OF DIPHTHAMIDE-EEF2%REACTOME%R-HSA-5358493.1 Synthesis of diphthamide-EEF2 DPH1 DPH2 DPH3 DPH5 DPH6 DPH7 EEF2 HOST INTERACTIONS OF HIV FACTORS%REACTOME%R-HSA-162909.1 Host Interactions of HIV factors NUP107 NUP188 PSIP1 BANF1 KPNA1 HMGA1 NUP62 NDC1 NUP214 SEC13 CD4 CD8B NUP133 NUP210 DOCK2 NUP93 NUP50 NUP54 POM121 NUP205 AAAS NUP160 LCK CD28 NUP85 TPR NUP88 NUP43 RAE1 ATP6V1H RANBP2 PPIA NUP155 RANBP1 NUP153 NUP35 NUPL2 NUP37 HCK AP1G1 PACS1 AP1S2 AP1B1 AP1S1 AP1S3 HLA-A ARF1 B2M AP1M2 AP2A1 AP1M1 AP2B1 AP2A2 AP2S1 PSMD8 PSMD9 AP2M1 PSMD6 XPO1 PSMD7 PSMD4 RAC1 PSMD5 PSMD2 PSMD3 PSMD1 ELMO1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 UBA52 PSMD10 TCEB2 PSMB11 TCEB1 PSMD12 PSMD11 PSMD14 FYN PSMD13 NPM1 PSMA7 PSMB10 PAK2 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 UBB PSMB3 UBC PSMB1 PSMF1 CCNT1 RPS27A KPNB1 SHFM1 PSMB8 PSMB9 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 RANGAP1 RCC1 RAN SLC25A5 CDK9 SLC25A4 SLC25A6 BTRC SKP1 CUL5 RBX1 TRANSPORT OF NUCLEOTIDE SUGARS%REACTOME DATABASE ID RELEASE 72%727802 Transport of nucleotide sugars SLC35B4 SLC35D1 SLC35A2 SLC35A1 SLC35A3 SLC35C1 SLC35B3 SLC35D2 SLC35B2 ORGANIC ANION TRANSPORTERS%REACTOME%R-HSA-428643.2 Organic anion transporters SLC25A18 SLC17A6 SLC17A5 SLC17A1 SLC25A22 SLC5A5 SLC5A8 SLC17A7 SLC17A8 SLC25A10 DISINHIBITION OF SNARE FORMATION%REACTOME%R-HSA-114516.4 Disinhibition of SNARE formation PRKCA STX4 STXBP3 PRKCG PRKCB CARBOHYDRATE METABOLISM%REACTOME DATABASE ID RELEASE 72%71387 Carbohydrate metabolism SDC4 SDC2 HS2ST1 SDC3 CHST11 CHST12 CHST15 CHST13 B4GALNT2 ALDH1A1 RBKS EXT1 EXT2 UGP2 CHSY1 SDC1 CHSY3 LUM KHK GAA XYLB HSPG2 RHD AGL HS3ST3A1 FMOD CHPF NAGLU SHPK CHP1 GYG2 GYG1 RHCE CEMIP HEXB GALK1 HEXA B3GALT2 B3GALT1 GALT IDUA SORD HAS1 HS3ST5 HAS3 HS3ST6 HAS2 RPE HS3ST4 HS3ST1 HS3ST2 GALE XYLT2 XYLT1 HPSE2 EPM2A GNS SLC9A1 ST3GAL4 ST3GAL6 B3GALT4 B3GALT6 ST3GAL1 B3GALT5 ST3GAL2 ST3GAL3 PYGB PYGM PYGL ST6GALNAC6 STAB2 GYS2 GYS1 TKT PAPSS2 PAPSS1 MANBA GLYCTK B3GNT7 B3GNT4 B3GNT3 B3GNT2 NDST2 CSGALNACT1 NDST1 LYVE1 SLC25A1 NDST4 GPI CSGALNACT2 NUP107 NDST3 NUP188 KERA ADPGK ENO1 PGD ENO2 ENO3 SLC26A2 HK2 PHKA1 SLC26A1 HK1 PHKA2 HK3 PPP2R1B PPP2R1A HMMR PRKACG NUP62 PRKACA PRKACB NDC1 NUP214 SEC13 TPI1 G6PC PHKB PPP1R3C NUP133 NUP210 PGAM1 PGAM2 MAN2B2 PPP2R5D MAN2B1 BPGM PGM2L1 NUP93 B4GALT2 B4GALT3 NUP50 PGP B4GALT1 GAPDHS SLC2A1 NUP54 ALDOC SLC25A10 ALDOB SGSH SLC25A12 ALDOA CHPF2 SLC25A11 GAPDH FBP1 FBP2 B4GAT1 SLC25A13 PFKFB2 PFKFB1 MAN2C1 POM121 GUSB NUP205 PFKFB4 ARSB PFKFB3 RPEL1 AAAS NUP160 PPP2CA PPP2CB NUP85 TPR PGK1 DCXR NUP88 ABCC5 NUP43 PGK2 PCK1 RAE1 LALBA PCK2 B4GALT6 RANBP2 B4GALT7 AKR1B1 GCKR B4GALT4 SLC37A1 B4GALT5 NUP155 MDH1 GOT1 MDH2 GOT2 HYAL1 CHST6 NUP153 PRELP HYAL2 CHST7 GCK HYAL3 G6PC2 B3GAT3 PFKL G6PC3 B3GAT2 IDS B3GAT1 GNPDA1 PC GNPDA2 NUP35 SLC35B3 NUPL2 PFKM SLC35B2 PFKP NUP37 AKR1A1 CD44 HS6ST1 HS6ST2 CHST1 HS6ST3 GPC1 GPC3 CHST5 GPC2 GPC5 CHST2 GPC4 GPC6 CHST3 AGRN GLB1L FUT10 FUT11 SLC35D2 FUT2 FUT1 FUT4 FUT3 FUT6 UBA52 FUT5 DERA FUT7 FUT9 GBE1 TKFC UBB UBC RPS27A HS3ST3B1 OGN HPSE G6PD PGM2 PGLS PGM1 RPIA GLB1 PRPS2 PRPS1 PHKG1 PHKG2 BCAN VCAN DSEL NCAN UST DSE GLCE BGN CSPG5 CSPG4 CHST14 CRYL1 DCN OMD TALDO1 NHLRC1 REPRESSION OF WNT TARGET GENES%REACTOME%R-HSA-4641265.3 Repression of WNT target genes TLE4 TLE3 TLE2 TLE1 LEF1 HDAC1 CTBP1 TCF7 TCF7L2 TCF7L1 CTBP2 AES NEGATIVE REGULATION OF MAPK PATHWAY%REACTOME%R-HSA-5675221.3 Negative regulation of MAPK pathway PPP2CA PPP2CB DUSP5 DUSP2 MAP2K1 DUSP1 PPP2R5B MAP2K2 PPP2R5A DUSP8 BRAF DUSP9 DUSP16 RAF1 DUSP10 ARAF PEBP1 PPP2R5C KSR1 UBA52 PPP2R1B PPP2R1A PPP5C MARK3 HRAS DUSP4 PPP2R5D NRAS UBB DUSP6 UBC DUSP7 YWHAB RPS27A PAQR3 BRAP MAPK1 MAPK3 PPP2R5E LTC4-CYSLTR MEDIATED IL4 PRODUCTION%REACTOME DATABASE ID RELEASE 72%9664535 LTC4-CYSLTR mediated IL4 production GGT1 CYSLTR2 DPEP2 DPEP1 DPEP3 GGT5 CYSLTR1 MRNA SPLICING%REACTOME%R-HSA-72172.3 mRNA Splicing POLR2E POLR2F POLR2H SF3B1 POLR2K POLR2L CPSF4 CPSF7 CPSF1 CSTF3 CPSF3 CSTF2 CPSF2 CSTF2T WDR33 PDCD7 NUDT21 HNRNPU FIP1L1 CWC25 PABPN1 HNRNPR CLP1 CWC27 PCF11 CCAR1 PAPOLA SNRPA1 EFTUD2 CSTF1 CWC22 SYMPK TXNL4A DDX5 SNRNP35 SRRM2 SNRPN ZCRB1 WBP11 CRNKL1 PRPF4 HNRNPF PRPF6 HNRNPA2B1 HNRNPUL1 PRPF3 SNRNP27 CD2BP2 PPIH SNRNP25 SNRNP200 SNRPC SNRPA SF1 RNPC3 PRPF8 PCBP1 ZMAT5 ZRSR2 PRPF38A FUS CWC15 NCBP1 LSM5 NCBP2 LSM4 LSM3 GTF2F1 LSM2 GTF2F2 CHERP HNRNPL POLR2A LSM8 POLR2B HNRNPM POLR2C LSM7 POLR2D LSM6 POLR2G HNRNPK HNRNPD HNRNPC SUGP1 POLR2I DDX46 POLR2J DDX42 PPWD1 YBX1 USP39 ELAVL2 PQBP1 PTBP1 SART1 SNRNP70 DHX15 DHX16 CTNNBL1 BCAS2 RBM5 RBM17 BUD31 PRPF40A TFIP11 SNRPD2 PLRG1 SNRPD1 GCFC2 SNRPD3 NHP2L1 SYF2 SNRPG HNRNPH1 HNRNPH2 DNAJC8 SNRPE SKIV2L2 RBM22 SF3B4 SNRPF SF3B5 SF3B2 SNRPB SF3B3 SF3B6 DDX23 WBP4 PRCC SRRT PUF60 TRA2B SNRPB2 HNRNPA1 SMNDC1 SRSF10 HNRNPA0 ELAVL1 SF3A3 SF3A1 HNRNPA3 PPIL1 SF3A2 GPKOW CDC5L U2SURP SNRNP40 PHF5A PRPF31 SNRNP48 PPIL3 RBMX PPIL4 PPIL6 AQR PRPF19 HSPA8 EIF4A3 CASC3 MAGOH XAB2 CDC40 SRRM1 SRSF2 SRSF3 SNW1 SRSF4 SRSF5 SRSF6 SRSF7 SLU7 SRSF9 RBM8A SRSF1 U2AF1 U2AF1L4 PPIE PCBP2 U2AF2 DHX38 SRSF11 UPF3B MAGOHB RNPS1 DHX9 ISY1 INITIAL TRIGGERING OF COMPLEMENT%REACTOME%R-HSA-166663.2 Initial triggering of complement IGKV3-11 COLEC11 FCN2 FCN3 COLEC10 MASP1 MBL2 IGKV2-28 FCN1 C4B C4A IGHG4 IGKV3D-20 IGHG1 C1QB IGHG2 C1QA IGKV1-12 C1S C1R C4B_2 CRP C2 IGKV2D-28 IGKV4-1 CFD IGKV2D-30 C3 GZMM CFB IGKV5-2 C1QC HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM%REACTOME DATABASE ID RELEASE 72%1638091 Heparan sulfate heparin (HS-GAG) metabolism SDC4 HS2ST1 SDC2 SDC3 NDST2 NDST1 NDST4 SLC35D2 NDST3 IDUA EXT1 EXT2 HS3ST5 HS3ST6 HS3ST4 SDC1 HS3ST1 HS3ST2 XYLT2 XYLT1 HPSE2 SGSH HSPG2 HS3ST3B1 GUSB HPSE B3GALT6 HS3ST3A1 B4GALT7 GLB1 B3GAT3 B3GAT2 NAGLU IDS B3GAT1 HS6ST1 HS6ST2 HS6ST3 GPC1 GPC3 GPC2 BCAN GPC5 VCAN GPC4 GPC6 NCAN GLCE BGN CSPG5 CSPG4 DCN AGRN GLB1L RNA POLYMERASE I TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 72%73863 RNA Polymerase I Transcription Termination TAF1B CDK7 TAF1C TAF1A TWISTNB POLR2E MNAT1 POLR2F POLR2H PTRF POLR2K CCNH POLR2L TTF1 GTF2H1 ZNRD1 GTF2H2 GTF2H3 GTF2H4 UBTF GTF2H5 TBP ERCC3 CD3EAP ERCC2 POLR1A POLR1B POLR1C POLR1E TAF1D PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 72%72203 Processing of Capped Intron-Containing Pre-mRNA CPSF4 CPSF7 CPSF1 CSTF3 CPSF3 CSTF2 CPSF2 CSTF2T WDR33 NUDT21 PDCD7 HNRNPU FIP1L1 CWC25 PABPN1 HNRNPR CLP1 PCF11 CWC27 CCAR1 PAPOLA SNRPA1 CSTF1 EFTUD2 SYMPK CWC22 TXNL4A DDX5 SNRNP35 SRRM2 SNRPN ZCRB1 WBP11 CRNKL1 HNRNPF PRPF4 HNRNPA2B1 PRPF6 HNRNPUL1 PRPF3 SNRNP27 CD2BP2 PPIH SNRNP25 SNRNP200 SNRPC SNRPA SF1 RNPC3 PRPF8 PCBP1 ZMAT5 ZRSR2 PRPF38A FUS CWC15 NCBP1 LSM5 NCBP2 LSM4 LSM3 GTF2F1 LSM2 GTF2F2 CHERP HNRNPL POLR2A LSM8 POLR2B HNRNPM POLR2C LSM7 POLR2D LSM6 POLR2G HNRNPK HNRNPD HNRNPC SUGP1 POLR2I DDX46 POLR2J DDX42 PPWD1 USP39 ELAVL2 PQBP1 PTBP1 SART1 SNRNP70 DHX15 DHX16 CTNNBL1 BCAS2 RBM5 RBM17 BUD31 PRPF40A TFIP11 SNRPD2 PLRG1 SNRPD1 GCFC2 SNRPD3 NHP2L1 SYF2 HNRNPH1 SNRPG HNRNPH2 DNAJC8 SNRPE SKIV2L2 RBM22 SF3B4 SF3B5 SNRPF SF3B2 SF3B3 SNRPB SF3B6 DDX23 WBP4 PRCC SRRT PUF60 TRA2B SNRPB2 HNRNPA1 SMNDC1 SRSF10 HNRNPA0 SF3A3 SF3A1 HNRNPA3 PPIL1 SF3A2 GPKOW CDC5L U2SURP SNRNP40 PHF5A PRPF31 SNRNP48 PPIL3 RBMX PPIL4 PPIL6 AQR METTL3 SLBP METTL14 WTAP PRPF19 XAB2 SNW1 PPIE PCBP2 DHX9 ISY1 POLR2E POLR2F POLR2H SF3B1 NUP107 NUP188 POLR2K POLR2L NUP62 NDC1 NUP214 SEC13 NUP133 NUP210 NUP93 NUP50 NUP54 POM121 NUP205 AAAS NUP160 NUP85 TPR NUP88 NUP43 RAE1 RANBP2 YBX1 NUP155 NUP153 NUP35 NUPL2 NUP37 ELAVL1 HSPA8 NXT1 EIF4A3 CASC3 GLE1 MAGOH THOC1 THOC3 EIF4E THOC2 THOC5 THOC7 CDC40 THOC6 SRRM1 DDX39A DDX39B ZC3H11A SARNP SRSF2 SRSF3 SRSF4 SRSF5 SRSF6 SRSF7 SLU7 SRSF9 FYTTD1 LUZP4 RBM8A POLDIP3 SRSF1 U2AF1 U2AF1L4 NXF1 NXF2 U2AF2 DHX38 SRSF11 CHTOP UPF3B MAGOHB NXF2B RNPS1 EXPORT OF VIRAL RIBONUCLEOPROTEINS FROM NUCLEUS%REACTOME%R-HSA-168274.3 Export of Viral Ribonucleoproteins from Nucleus NUP85 TPR NUP88 NUP43 RAE1 RANBP2 NUP107 NUP155 NUP188 NUP153 RAN NUP62 NUP35 NUPL2 NDC1 NUP214 SEC13 NUP37 NUP133 NUP210 NUP93 NUP50 NUP54 POM121 XPO1 NUP205 AAAS NUP160 CYTOCHROME C-MEDIATED APOPTOTIC RESPONSE%REACTOME%R-HSA-111461.3 Cytochrome c-mediated apoptotic response APIP CARD8 CASP9 APAF1 XIAP CYCS CASP7 CASP3 AVEN MAPK1 DIABLO UACA MAPK3 TALDO1 DEFICIENCY: FAILED CONVERSION OF FRU(6)P, E4P TO SH7P, GA3P%REACTOME DATABASE ID RELEASE 72%6791462 TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P TALDO1 PURINERGIC SIGNALING IN LEISHMANIASIS INFECTION%REACTOME DATABASE ID RELEASE 72%9660826 Purinergic signaling in leishmaniasis infection CASP1 SUGT1 HSP90AB1 C3AR1 P2RX7 TXNIP MEFV P2RX4 CTSG IL18 IL1A TXN IL1B NFKB1 NFKB2 C3 PYCARD ENTPD1 NLRP3 ENTPD5 RELA NT5E PSTPIP1 REGULATION OF GENE EXPRESSION IN EARLY PANCREATIC PRECURSOR CELLS%REACTOME DATABASE ID RELEASE 72%210747 Regulation of gene expression in early pancreatic precursor cells ONECUT3 ONECUT1 PTF1A NKX6-1 PDX1 HNF1B FGF10 SIGNALING BY GPCR%REACTOME%R-HSA-372790.4 Signaling by GPCR GRM7 GRM6 PRKAR2B GPER1 GRM8 PRKAR2A QRFPR SSTR1 SSTR2 PTCH1 SSTR4 SSTR5 HTR6 CNR2 HTR7 GNAS CNR1 HTR1E TAS1R2 HTR1F TAS1R1 HTR1D TAS1R3 HTR2B CCK HTR1A OPN1SW HTR1B ACKR1 HTR2C RXFP4 HTR2A GRPR HTR4 RXFP3 HTR5A PROK2 PROK1 CMKLR1 GNA14 TRHR ADCY4 GNA15 GALR3 ADCY3 GALR2 GALR1 ADCY2 WNT10B ADCY1 WNT10A ADCY8 GNA11 FZD9 ADCY7 GPR183 ADCY6 PNOC ADCY5 GPR132 OPN1LW GAST OPN1MW RGR GPR4 HCAR2 GPR143 HCAR3 DGKG HCAR1 DGKE CHRM1 DGKD DGKB CHRM4 LRAT DGKA CHRM5 GUCA1B GUCA1A GUCA1C ABHD12 HSPG2 DGKZ MTNR1A MTNR1B DGKQ DGKK RBP4 PPEF1 DGKI RBP2 DGKH ABHD6 RBP1 PPP3CC STRA6 DAGLA TRH PPP3R1 INSL5 DAGLB RCVRN METAP1 METAP2 NMT1 OXTR RRH AVP EDNRA EDNRB UTS2R RETSAT GPR37L1 UTS2B PTGFR NLN NMT2 PPY NTSR1 NTSR2 NMB NMBR NMS NMU QRFP BRS3 CCKAR FFAR3 FFAR2 EDN1 EDN2 EDN3 AVPR1B AVPR1A CCKBR NPB GUCY2D PTGER1 GPIHBP1 PTGER3 HRAS GUCY2F NPW KISS1R F2RL1 F2RL2 F2RL3 CCL4L2 PMCH NPY2R NRAS SDR9C7 GHSR NPY1R RGS9BP APLNR SUCNR1 NTS OPN4 OPN3 C3 PTCH2 OPN5 PYY NMUR2 NMUR1 GPSM1 TAS2R7 GPSM2 TAS2R9 TAS2R8 WNT2B MLNR HEBP1 PDE4B BDKRB2 BDKRB1 TAS2R1 TAS2R3 GPSM3 TAS2R5 TAS2R4 NPY5R WNT16 CORT RGS18 RGS14 RGS13 NPY4R OPRL1 GNA12 RGS21 S1PR3 RGS22 S1PR2 S1PR5 S1PR4 OPRK1 SHH KISS1 DHH RGS10 IHH RGS12 HRH1 HRH3 HRH4 WNT9A WNT8A WNT8B WNT1 WNT3 WNT4 PIK3CG PIK3R1 EGFR PIK3CA SOS1 LRP1 PPP3CA PPP3CB ARHGEF18 RHOA LRP2 LRP8 CXCL8 UCN PIK3R3 FFAR4 PIK3R6 PIK3R5 GPR17 LTB4R2 LTB4R GRP P2RY1 GPC1 GPC3 AHCYL1 GPC2 GPC5 GPC4 GPC6 AKR1C1 AKT2 AKR1C3 AKT3 AKR1C4 CXCL12 PPP1CA PTAFR VAV3 PRKCB PDPK1 VAV1 VAV2 ROCK1 ROCK2 CCR5 ITPR1 ITPR2 CXCR4 ITPR3 PIK3R2 CDC42 PAK1 TRIO ITSN1 PREX1 ARHGEF40 OBSCN NGEF ARHGEF26 CLPS KALRN ABR ECT2 ARHGEF33 ARHGEF35 ARHGEF37 ARHGEF39 ARHGEF38 NET1 RASGRF2 ARHGEF10L AKAP13 MCF2L RASGRP2 ARHGEF11 ARHGEF10 VIPR1 RASGRP1 ARHGEF12 VIPR2 SCT PLEKHG2 ARHGEF15 RXFP1 ARHGEF17 RXFP2 PLEKHG5 ARHGEF16 CYSLTR1 ARHGEF19 GPR176 ARHGEF9 ARHGEF3 PTGDR LHCGR ARHGEF4 TAAR8 ARHGEF1 TAAR9 ARHGEF2 TAAR6 TAAR5 SOS2 ARHGEF5 TAAR2 TAAR1 ADCYAP1 PLCB3 PLCB4 FGD1 PLCB1 FGD2 IAPP ADCYAP1R1 PLCB2 FGD3 CALCA GNA13 FGD4 CALCRL CALCB GIPR MCF2 GPR83 ADRB1 GPR84 ADRB2 CRHR1 CRHR2 GHRHR MC2R CALCR HRH2 DRD1 DRD5 GPR15 MC1R RLN2 RLN3 GPR27 GPR25 ANXA1 AGT GPR20 ADM PTH1R MC4R CHRM3 INSL3 GPR39 FSHB GPR32 AVPR2 GLP2R GPBAR1 PTH2R GIP MC3R ADORA2A ADRB3 ADORA2B FSHR CRH NPSR1 PTGER4 RAMP2 RAMP3 GPR45 PTH PTGER2 PRKX PTH2 PTHLH NPS GPR150 PSAP GPHA2 P2RY11 SCTR TSHR GHRH ADM2 MC5R VIP RAMP1 GPHB5 C3AR1 ADRA2C ADRA2A FPR1 FPR2 AKR1B10 FFAR1 TACR2 TACR3 TAC3 TACR1 TAC1 DRD2 DRD3 DRD4 PPBP OPRD1 CYP4V2 TSHB SLC24A1 PDE6G MMP3 CNGA1 RHO OPRM1 SAG PDE6B PDE6A CNGB1 S1PR1 CXCR1 CXCR2 POMC C5AR2 C5AR1 C5 CXCL1 CD55 ADGRE5 ADGRE3 P2RY12 P2RY13 P2RY10 P2RY14 LPAR4 P2RY6 P2RY4 LPAR6 ADORA3 P2RY2 ADORA1 ARRB2 ADRA1D ADRA1B ADRA1A KPNA2 CXCL6 CXCL9 CXCL3 CXCL13 CXCL2 CX3CL1 CXCL5 CXCL16 CCRL2 CCR9 CCR8 CCR7 CCR6 CCR4 CCR3 CCR2 XCL2 XCL1 CX3CR1 CCL13 CCL11 CCL3L1 CCL3L3 PLB1 CXCR5 CXCR6 CCL7 APP CCL5 CXCR3 CCL4 CCL3 ARRB1 CCL2 CCL1 CCL19 CCL17 CCL16 CCR10 CCL25 CCR1 SSTR3 CCL22 XCR1 CCL21 CCL20 CXCL10 CXCL11 ACKR4 ACKR3 ACKR2 MCHR1 CCL28 CCL27 WNT3A FZD4 FZD6 FZD8 PLA2G4A MGLL HBEGF AWAT2 CAMK4 KNG1 GNAT2 GNAT3 GNAT1 F2R RGS9 RGS6 F2 RGS7 GNAZ PF4 GNG10 GNG12 GNG11 GNG13 GNAO1 GNB2 GNB1 GNB4 GNB3 GNB5 GNGT1 GNGT2 GNAI3 GNAI1 GNAI2 GNG3 GNG2 CHRM2 GNG5 GNG4 GNG7 GNG8 AGTR1 PLXNB1 RGS11 PPP2R1B PPP2R1A PRKACG WNT11 PRKACA PRKACB RDH11 PPP2R5D PPP2CA PPP2CB OR11H2 OR11H1 OR2M7 OR11H4 OR2M5 OR2M4 OR2M3 OR1K1 OR2M2 OR4K17 CAMKK1 OR4Q3 CAMKK2 OR2AE1 OR11H6 OR2L8 OR1J4 OR11G2 OR2L5 OR1J2 OR2L3 GABBR2 OR1J1 OR2L2 GABBR1 OR4P4 OR10AD1 OR5R1 OR6T1 OR4K15 OR4K14 OR4K13 OR13J1 OR1I1 OR2K2 OR6S1 FZD2 OR5M11 FZD5 OR5M10 WNT5A OR10D3 OR8B12 OR14K1 OR2J3 OR4N5 OR2J2 OR4N4 OR2J1 OR4N2 OR5P3 OR5P2 OR10C1 OR10J1 OR11L1 OR10J3 OR10J5 AGRN OR5W2 OR6Y1 OR52B2 OR52B6 OR1N2 OR1N1 OR5V1 OR6X1 OR52A1 OR52A5 OR10H1 OR10H3 OR10H2 OR10H5 OR10H4 OR1M1 OR4S2 GNAL DHRS3 OR4S1 ADRBK2 OR2AG1 NBEA OR2AG2 DHRS9 OR10G2 RDH10 OR14A16 RDH16 GRM1 OR1L8 OR10G4 RDH5 GRM5 OR1L6 OR10G3 OR1L4 OR1L3 OR1L1 OR5T3 OR5T2 OR5T1 RPS6KA3 OR6V1 OR10G6 OR10G8 RPS6KA2 OR10G7 RPS6KA1 OR10G9 OR52W1 OR1S2 OR1S1 OR13D1 OR14C36 OR5AS1 OR2T8 OR2T7 OR2T6 OR2T5 OR2T4 OR2T3 OR2T2 CREB1 OR13C9 OR2T1 OR13C8 OR4X2 OR2L13 OR4X1 OR9A4 OR51T1 OR9A2 OR13C3 MAPK7 OR13C2 MAPK1 OR13C5 OR13C4 MAPK3 OR5AR1 OR2S2 OR1Q1 ABCA4 OR51S1 OR4A47 OR5B21 REEP1 REEP5 REEP4 CDK5 REEP3 REEP2 REEP6 OR13A1 OR7E24 OR7A10 OR14J1 OR13H1 OR2Y1 OR56B1 OR8D4 OR8D2 OR56B4 OR8D1 OR7A17 OR6C70 OR6C76 OR6C75 OR6C74 OR13G1 OR14I1 OR10A7 OR56A5 TBXA2R OR7A5 OR10A2 OR10A4 OR56A4 OR10A3 OR56A3 OR10A6 OR10A5 OR56A1 RGS17 OR6C65 RGS19 OR2W3 RGSL1 OR8B8 RGS16 OR2W1 RGS4 OR8B4 RGS20 PRKCH OR8B3 OR6C68 OR13F1 OR8B2 OR12D3 OR12D2 OR5AU1 OR51V1 OR2V2 OR2V1 OR11A1 OR8A1 OR7G2 OR8I2 OR7G1 OR9K2 OR52N1 OR52N5 OR52N4 CAMK2B OR52N2 OR51L1 SDC4 CAMK2D SDC2 OR5D18 CAMK2A SDC3 OR10W1 OR2A42 OR5D16 OR5B3 APOM OR5B2 OR5D14 OR8H3 APOE OR5D13 CAMK2G APOB OR8H2 OR8H1 OR52M1 OR10V1 PRKCG OR4C12 OR2AT4 OR6C6 OR4C11 OR6C4 OR5A2 OR8G5 OR6C3 OR4C16 OR5AK2 OR5A1 SDC1 OR6C2 OR4C15 OR6C1 OR4C13 OR8G1 OR9I1 OR10T2 OR51J1 OR52L1 OR7D4 OR6B3 OR6B2 OR6B1 OR7D2 OR2A25 OR51I2 OR10S1 OR52K2 OR51I1 OR52K1 PDE3A OR4D11 OR2Z1 OR4D10 OR2A12 OR6A2 OR9G4 OR7C2 HSD17B1 OR7C1 OR9G1 OR2A14 OR2A1 OR4E2 OR51Q1 GCG OR4D9 OR5AP2 OR5B12 OR4D6 OR4D5 OR5B17 OR4D2 OR4D1 OR5F1 OR10Z1 OR52R1 OR4C6 OR4C5 OR3A3 OR3A2 OR4A15 OR4C3 OR14A2 OR3A1 OR4A16 OR8K5 OR8K3 OR8K1 OR5AN1 OR4B1 OR4C46 OR8J3 OR6F1 OR8J1 OR51M1 OR10X1 OR4A5 OR7G3 OR5C1 OR1C1 OR5K4 OR5K3 OR5K2 OR51D1 OR5K1 OR6M1 OR2T12 OR2T10 OR2T11 OR5H15 OR5H14 PDE8B PDE8A OR2D3 OR2D2 OR1B1 GNAQ OR52E4 OR5J2 OR52E2 OR5AC2 OR52E8 OR52E6 OR52E5 OR2C3 OR1A2 OR6K6 OR1A1 OR2C1 OR51B2 OR6K3 OR6K2 OR5I1 OR52D1 OR9Q2 OR9Q1 OR2AK2 GRK5 GRK6 OR51B6 OR51B5 OR51B4 OR2B6 OR4F6 OR4F5 OR5H6 OR2B3 OR10K2 OR4F4 OR2B2 OR10K1 OR4F3 OR5H2 OR5H1 FNTA OR6J1 OR2AJ1 OR51A4 OR2A7 OR51A2 OR2A5 OR2A4 OR51A7 OR2A2 RTP4 RTP5 OR52J3 RTP2 OR51H1 RTP3 PRKCQ RTP1 OR1G1 OR4M2 OR4M1 OR10R2 OR10AG1 OR6Q1 OR8U1 PDE4A OR51G2 OR52I2 OR51G1 OR52I1 OR1F1 PDE4D OR2H2 PDE4C OR2H1 OR4L1 OR10Q1 OR6P1 OR2B11 OR2AP1 OR51F2 OR2G6 OR51F1 OR5M9 OR52H1 OR5M8 OR2G3 OR1E2 OR4K5 CGA OR2G2 OR1E1 OR5M3 OR4K2 OR4K1 OR5M1 OR10P1 OR2T34 OR8S1 OR2T35 OR2T33 OR4F29 OR4F21 OR1D5 OR2T27 OR51E1 OR1D2 OR2F2 OR2F1 OR2T29 OR51E2 OR5L2 OR6N2 OR5L1 OR6N1 OR4F17 OR4F16 OR4F15 PDE7B PDE7A LDLR NPY CYSLTR2 APOA2 APOA1 APOA4 TTR BCO2 BCO1 APOC3 APOC2 SAA1 PDE1B PDE1A PDE2A PDE11A PDE10A PRKCE SRC TIAM2 TRPC7 AKT1 PTGIR TRPC6 TRPC3 PRKCD PRKCA ARHGEF7 LHB RHOC RHOB TIAM1 PDE1C FZD10 ADRBK1 CRHBP PDYN RBP3 FZD1 AGTR2 FZD3 FPR3 RDH12 FZD7 NPBWR1 NPBWR2 HCRT NAPEPLD GPR18 GPRC6A PDE3B UCN3 UCN2 GPR37 GPR35 WNT9B GPR31 PROKR1 PROKR2 WNT7B GPR55 WNT7A GPR68 GPR65 FNTB UTS2 ECE1 RLBP1 PRLHR HCRTR2 HCRTR1 APLN OPN1MW2 NPFFR2 NPFFR1 TAS2R20 OXER1 TAS2R10 NPFF TAS2R13 TAS2R14 TAS2R16 MYO7A TAS2R19 KEL TAS2R40 TAS2R41 TAS2R42 TAS2R43 TAS2R46 LPAR1 LPAR2 LPAR3 PENK TAS2R30 TAS2R31 TAS2R38 TAS2R39 RPE65 LPAR5 PPP1R1B GNRH2 GNRH1 PNLIP TAS2R60 PTGDR2 MLN GNRHR OXGR1 LPL TAS2R50 GAL HSD17B6 PRLH XK RGS5 RGS2 RGS3 RGS1 RGS8 CASR CAMKMT PCP2 ARHGEF25 MCHR2 GRK1 BTK WNT6 ARHGEF6 GRK7 WNT2 LRP10 OXT LRP12 GRM3 ADCY9 GLP1R PRKAR1B ADGRE1 SMO ADGRE2 PRKAR1A GRM2 SST GRM4 ABACAVIR TRANSMEMBRANE TRANSPORT%REACTOME%R-HSA-2161517.2 Abacavir transmembrane transport SLC22A3 ABCB1 SLC22A2 ABCG2 SLC22A1 PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS%REACTOME DATABASE ID RELEASE 72%202427 Phosphorylation of CD3 and TCR zeta chains PTPRC PAG1 CD4 HLA-DQA2 HLA-DQA1 HLA-DRB5 HLA-DPA1 HLA-DRB4 HLA-DPB1 CD3G HLA-DRA HLA-DRB3 TRAV19 HLA-DRB1 PTPN22 PTPRJ CD3E CD3D HLA-DQB2 HLA-DQB1 CSK LCK PARADOXICAL ACTIVATION OF RAF SIGNALING BY KINASE INACTIVE BRAF%REACTOME DATABASE ID RELEASE 72%6802955 Paradoxical activation of RAF signaling by kinase inactive BRAF CAMK2D CAMK2A MAP2K1 MAP2K2 BRAF RAF1 CAMK2G ITGA2B ARAF PEBP1 IQGAP1 ARRB2 JAK2 KSR1 KSR2 APBB1IP CNKSR2 CNKSR1 VCL ARRB1 KRAS PHB RAP1B FGB MARK3 HRAS FGA FN1 VWF RAP1A FGG NRAS ITGB3 YWHAB BRAP SRC MAPK1 CSK MAPK3 TLN1 CAMK2B MAP3K11 PYRUVATE METABOLISM%REACTOME%R-HSA-70268.6 Pyruvate metabolism PDHB PDPR VDAC1 MPC1 MPC2 DLD PDP1 ME1 PDP2 SLC16A1 LDHAL6A LDHAL6B GSTZ1 RXRA GLO1 PDHA2 PDHA1 PPARD SLC16A8 DLAT PDK4 SLC16A3 PDK3 BSG PDK2 PDK1 PDHX LDHC LDHB LDHA G PROTEIN GATED POTASSIUM CHANNELS%REACTOME DATABASE ID RELEASE 72%1296059 G protein gated Potassium channels GNG11 GNG13 KCNJ3 KCNJ5 GNB2 KCNJ6 KCNJ10 GNB1 GNB4 KCNJ2 KCNJ9 KCNJ15 GNB3 KCNJ4 KCNJ16 KCNJ12 GNB5 GNGT1 GNGT2 GABBR2 GABBR1 GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 GNG10 GNG12 ANTIMICROBIAL PEPTIDES%REACTOME DATABASE ID RELEASE 72%6803157 Antimicrobial peptides DEFB107B DEFB104B DEFB106B DEFA1B DEFB104A DEFB119 DEFB118 DEFB116 DEFB115 DEFB136 DEFB114 DEFB135 DEFB113 CCR6 DEFB134 DEFB112 BPI DEFB133 CCR2 DEFB132 DEFB108B DEFB110 DEFB131 DEFB106A DEFB4A DEFB4B SLC11A1 CD4 PRSS3 TLR1 CTSG TLR2 PGLYRP1 PRSS2 PDZD11 RNASE3 PRTN3 PGLYRP4 PGLYRP3 PGLYRP2 LEAP2 HTN1 S100A7A HTN3 BPIFA1 GNLY BPIFA2 EPPIN DCD LYZ RNASE6 REG3A ITLN1 REG3G EPPIN-WFDC6 ART1 RNASE8 RNASE7 PI3 CHGA DEFA6 DEFA5 DEFA3 BPIFB2 BPIFB1 BPIFB4 LCN2 BPIFB6 CLU SEMG1 ATOX1 DEFB103A DEFB103B DEFB105A ELANE DEFB105B ATP7A S100A9 DEFB129 S100A8 DEFB128 S100A7 DEFB127 DEFB126 DEFB125 DEFB124 DEFB1 DEFB123 DEFA4 PLA2G2A LTF DEFB107A DEFA1 DEFB121 PENTOSE PHOSPHATE PATHWAY%REACTOME%R-HSA-71336.6 Pentose phosphate pathway PGM2 TKT PGLS RBKS PGD RPIA DERA SHPK TALDO1 RPE PRPS2 PRPS1 G6PD RPEL1 SIGNALING BY RAS MUTANTS%REACTOME%R-HSA-6802949.2 Signaling by RAS mutants CAMK2D CAMK2A MAP2K1 MAP2K2 BRAF RAF1 CAMK2G ITGA2B ARAF PEBP1 IQGAP1 ARRB2 JAK2 KSR1 KSR2 APBB1IP CNKSR2 CNKSR1 VCL ARRB1 KRAS PHB RAP1B FGB MARK3 HRAS FGA FN1 VWF RAP1A FGG NRAS ITGB3 YWHAB BRAP SRC MAPK1 CSK MAPK3 TLN1 CAMK2B MAP3K11 FICOLINS BIND TO REPETITIVE CARBOHYDRATE STRUCTURES ON THE TARGET CELL SURFACE%REACTOME%R-HSA-2855086.1 Ficolins bind to repetitive carbohydrate structures on the target cell surface FCN1 FCN2 FCN3 MASP1 REGULATION OF PTEN MRNA TRANSLATION%REACTOME DATABASE ID RELEASE 72%8943723 Regulation of PTEN mRNA translation TNRC6A TNRC6B MOV10 AGO3 TNRC6C AGO4 AGO1 AGO2 PTEN INLA-MEDIATED ENTRY OF LISTERIA MONOCYTOGENES INTO HOST CELLS%REACTOME DATABASE ID RELEASE 72%8876493 InlA-mediated entry of Listeria monocytogenes into host cells UBC CTNND1 CDH1 RPS27A UBA52 SRC UBB CBLL1 CTNNB1 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B%REACTOME%R-HSA-174048.2 APC C:Cdc20 mediated degradation of Cyclin B ANAPC15 ANAPC16 ANAPC7 UBE2C UBE2E1 UBE2D1 ANAPC10 ANAPC11 CCNB1 UBB CDC23 CDC26 CDC27 CDC16 UBC CDK1 ANAPC4 ANAPC5 RPS27A UBA52 ANAPC1 ANAPC2 CDC20 IRF3 MEDIATED ACTIVATION OF TYPE 1 IFN%REACTOME DATABASE ID RELEASE 72%1606341 IRF3 mediated activation of type 1 IFN DTX4 NLRP4 TBK1 IRF3 ZBP1 AGGREPHAGY%REACTOME%R-HSA-9646399.2 Aggrephagy DYNC1I1 PARK2 PCNT PARK7 HDAC6 DYNC1H1 UBE2N UBB CETN1 DYNLL1 UBE2V1 UBC HSF1 CFTR RPS27A UBA52 DYNLL2 VCP HSP90AA1 DYNC1LI1 DYNC1I2 IFT88 DYNC1LI2 ARL13B DISEASES OF METABOLISM%REACTOME%R-HSA-5668914.2 Diseases of metabolism SDC4 SDC2 SDC3 NEU1 MOGS MUC20 EXT1 MAN1B1 EXT2 CHSY1 SDC1 ACY1 LUM KHK GAA AHCY HSPG2 CYP17A1 MC2R FMO3 FMOD ABCA3 NAGLU GYG2 GYG1 SLC34A2 DPAGT1 MPI ALG8 ALG9 ALG6 ALG14 ALG3 ALG13 ALG12 ALG1 ALG11 DHDDS MPDU1 NUS1 PMM2 CYP4F22 HEXB DOLK GALK1 RFT1 HEXA MGAT2 GIF GALT AMN IDUA GALE MCCC2 EPM2A MCCC1 GNS CYP19A1 POMT2 MMAA GALNT12 SEMA5A SEMA5B SPON2 CYP27A1 MUT SPON1 NOTCH1 THSD7B SRD5A3 POMT1 PCCA ADAMTSL1 PCCB B3GALT6 ADAMTS4 MAOA ADAMTS5 ADAMTS2 C1GALT1C1 ADAMTS3 ST3GAL3 ADAMTSL4 ADAMTS1 ADAMTSL3 ADAMTSL2 TCN2 MUC12 DAG1 MUC13 PAH MUC15 THSD7A ADAMTS8 ADAMTS9 ADAMTS6 ADAMTS7 SBSPON MUCL1 MUC3A POMGNT1 MUC5AC ADAMTS20 B3GLCT CFP ADAMTS12 THBS2 THSD1 THBS1 THSD4 ADAMTS10 ADAMTS16 ADAMTS15 ADAMTS14 GYS2 MUC1 ADAMTS13 GYS1 ADAMTS19 ADAMTS18 LARGE ADAMTS17 PAPSS2 MUC7 MUC4 MUC6 GFPT1 GALNT3 MUC17 C1GALT1 MUC5B MUC21 GSS FDX1L TPMT MMAB SI LCT KERA SLC26A2 G6PC PPP1R3C HLCS SFTA3 SFTPB ABCD4 SFTPA2 SFTPC SFTPD CSF2RB B4GALT1 SFTPA1 CSF2RA UGT1A1 ALDOB DPM1 SGSH DPM2 DPM3 B4GAT1 GUSB ARSB CTSA DCXR UGT1A4 B4GALT7 HYAL1 CHST6 PRELP B3GAT3 G6PC3 IDS PC NOTCH2 POMC NOTCH3 NOTCH4 LFNG CYP21A2 MTRR ALG2 GPC1 GPC3 GPC2 GPC5 GPC4 GNE GPC6 CHST3 HGSNAT AGRN CYP2U1 GGT1 SLC35D1 GALNS MAT1A ACACA UBA52 CYP11A1 CD320 GBE1 GCLC CYP11B2 CYP11B1 GCLM CYP7B1 UBB MTR UBC RPS27A TBXAS1 OGN LMBRD1 CYP27B1 CYP26B1 CYP24A1 CYP26C1 CYP2R1 PGM1 RPIA GLB1 FDXR CYP1B1 IDH1 BCAN CUBN VCAN NCAN BGN CSPG5 CSPG4 CHST14 DCN OMD TALDO1 MMACHC BTD MMADHC FDX1 NHLRC1 OPLAH IKK COMPLEX RECRUITMENT MEDIATED BY RIP1%REACTOME%R-HSA-937041.1 IKK complex recruitment mediated by RIP1 IKBKB CHUK UBE2D1 RIPK3 UBE2N BIRC2 BIRC3 UBB UBE2V1 UBC RPS27A UBA52 RIPK1 TRAF6 TICAM2 LY96 UBE2D2 TICAM1 UBE2D3 CD14 IKBKG TLR4 TRANSLATION INITIATION COMPLEX FORMATION%REACTOME DATABASE ID RELEASE 72%72649 Translation initiation complex formation RPS4X RPS3A FAU RPS27L PABPC1 RPS26 RPS25 RPS28 EIF1AX RPS27 RPS29 EIF2S2 RPS20 EIF2S1 RPS21 RPS24 EIF2S3 RPS23 EIF4A2 EIF4H EIF4A1 EIF3M EIF3K EIF3L EIF3I EIF3J EIF3G EIF3H EIF3E EIF3F EIF3C EIF3D EIF3A RPS4Y2 EIF3B RPS4Y1 RPS27A RPS3 RPS2 EIF4E EIF4G1 RPS9 EIF4B RPS7 RPS8 RPS5 RPS6 RPSA RPS15 RPS14 RPS17 RPS16 RPS19 RPS15A RPS18 RPS11 RPS10 RPS13 RPS12 BIOSYNTHESIS OF DPAN-3-DERIVED PROTECTINS AND RESOLVINS%REACTOME%R-HSA-9026286.1 Biosynthesis of DPAn-3-derived protectins and resolvins ALOX15 ALOX5 SEMA3A PAK DEPENDENT AXON REPULSION%REACTOME%R-HSA-399954.2 Sema3A PAK dependent Axon repulsion PAK2 CFL1 NRP1 HSP90AB1 LIMK1 PLXNA2 PLXNA1 PLXNA3 PAK1 HSP90AA1 SEMA3A FES PLXNA4 FYN RAC1 PAK3 PRE-MRNA SPLICING%REACTOME DATABASE ID RELEASE 72%72163 pre-mRNA splicing POLR2E POLR2F POLR2H SF3B1 POLR2K POLR2L CPSF4 CPSF7 CPSF1 CSTF3 CPSF3 CSTF2 CPSF2 CSTF2T WDR33 NUDT21 HNRNPU FIP1L1 CWC25 PABPN1 HNRNPR CLP1 CWC27 PCF11 CCAR1 PAPOLA SNRPA1 EFTUD2 CSTF1 CWC22 SYMPK TXNL4A DDX5 SRRM2 SNRPN WBP11 CRNKL1 PRPF4 HNRNPF PRPF6 HNRNPA2B1 HNRNPUL1 PRPF3 SNRNP27 CD2BP2 PPIH SNRNP200 SNRPC SNRPA SF1 PRPF8 PCBP1 PRPF38A FUS CWC15 NCBP1 LSM5 NCBP2 LSM4 LSM3 GTF2F1 LSM2 GTF2F2 CHERP HNRNPL POLR2A LSM8 POLR2B HNRNPM POLR2C LSM7 POLR2D LSM6 POLR2G HNRNPK HNRNPD HNRNPC SUGP1 POLR2I DDX46 POLR2J DDX42 PPWD1 YBX1 USP39 ELAVL2 PQBP1 PTBP1 SART1 SNRNP70 DHX15 DHX16 CTNNBL1 BCAS2 RBM5 RBM17 BUD31 PRPF40A TFIP11 SNRPD2 PLRG1 SNRPD1 GCFC2 SNRPD3 NHP2L1 SYF2 SNRPG HNRNPH1 HNRNPH2 DNAJC8 SNRPE SKIV2L2 RBM22 SF3B4 SNRPF SF3B5 SF3B2 SNRPB SF3B3 SF3B6 DDX23 WBP4 PRCC SRRT PUF60 TRA2B SNRPB2 HNRNPA1 SMNDC1 SRSF10 HNRNPA0 ELAVL1 SF3A3 SF3A1 HNRNPA3 PPIL1 SF3A2 GPKOW CDC5L U2SURP SNRNP40 PHF5A PRPF31 PPIL3 RBMX PPIL4 PPIL6 AQR PRPF19 HSPA8 EIF4A3 CASC3 MAGOH XAB2 CDC40 SRRM1 SRSF2 SRSF3 SNW1 SRSF4 SRSF5 SRSF6 SRSF7 SLU7 SRSF9 RBM8A SRSF1 U2AF1 U2AF1L4 PPIE PCBP2 U2AF2 DHX38 SRSF11 UPF3B MAGOHB RNPS1 DHX9 ISY1 PRESYNAPTIC DEPOLARIZATION AND CALCIUM CHANNEL OPENING%REACTOME DATABASE ID RELEASE 72%112308 Presynaptic depolarization and calcium channel opening CACNA1E CACNB2 CACNA2D2 CACNB1 CACNB3 CACNB4 CACNG2 CACNA2D3 CACNG4 CACNA1B CACNA1A ALANINE METABOLISM%REACTOME%R-HSA-8964540.1 Alanine metabolism GPT CROSS-PRESENTATION OF PARTICULATE EXOGENOUS ANTIGENS (PHAGOSOMES)%REACTOME%R-HSA-1236973.1 Cross-presentation of particulate exogenous antigens (phagosomes) ITGB5 NCF4 CYBB CYBA CD36 ITGAV NCF1 NCF2 SELECTIVE AUTOPHAGY%REACTOME DATABASE ID RELEASE 72%9663891 Selective autophagy MFN1 MFN2 TOMM70A NBR1 PCNT TOMM7 TOMM5 TOMM6 DYNC1H1 UBA52 DYNC1LI1 DYNC1LI2 PRKAA2 CSNK2A1 CSNK2A2 PARK7 CSNK2B UBB UBC RPS27A DYNLL2 HSPA8 PRKAB2 VDAC1 PRKAB1 DYNC1I1 UBE2N UBE2V1 EPAS1 HSF1 HSP90AA1 ATG12 TOMM20 TOMM22 ATG5 PLIN3 PARK2 PLIN2 ULK1 HDAC6 ATM MTERF3 CETN1 DYNLL1 MAP1LC3B MAP1LC3A FUNDC1 CFTR USP30 PRKAG1 PEX5 VCP PRKAG2 IFT88 SQSTM1 DYNC1I2 PRKAG3 TOMM40 ARL13B PINK1 SIGNALING BY NUCLEAR RECEPTORS%REACTOME%R-HSA-9006931.5 Signaling by Nuclear Receptors APOE ALDH1A1 SMC3 DDX5 RAD21 STAG1 NRIP1 STAG2 SMC1A APOD TNRC6C GPS2 CARM1 ABCG8 ABCG5 ARL4C EEPD1 GTF2F1 GTF2F2 TNRC6A POLR2A TNRC6B POLR2B POLR2C FOXO3 POLR2D UHMK1 POLR2G BCL2 POLR2I POLR2J ABCA1 HRAS BTC EPGN PDHA2 TGFA AREG NRAS PDHA1 HBEGF EREG MMP7 GPAM ESR2 STRN DLD S1PR3 HIST1H2AE HIST1H2AD HIST3H2BB HIST1H2AC HIST1H2AB HIST1H2AJ HIST2H3A HIST1H2BF PPP5C HIST1H2BE HIST1H2BH FABP5 HIST1H2BG GNAT3 HIST2H3D HIST1H2BB FABP6 HIST1H2BA HIST2H3C HIST1H2BD HIST1H2BC H2AFB1 HIST1H3J HIST1H3A HIST1H3F HIST1H3G HIST1H3H HIST1H3I HIST1H3B HIST1H3C HIST1H3D HIST1H3E H3F3B MYC GNG10 HIST1H4K ADH4 HIST1H4L H3F3A GNG12 H2BFS GNG11 HIST1H4A GNG13 TLE3 HIST1H4B HIST1H4H HIST1H4I GNB2 HIST1H4J FKBP5 HIST1H4C GNB1 GNB4 HIST1H4D HSP90AB1 HIST1H4E GNB3 HIST1H4F GNB5 HIST2H2AA3 YY1 HIST2H2AA4 EGF GNGT1 PIK3R1 HIST2H2AC GNGT2 EGFR PIK3CA H2AFJ TBP H2AFZ NCOR2 H2AFX NCOR1 HDAC3 ZDHHC7 H2AFV CRABP2 GNAI3 RXRG HIST2H2BE PLIN1 GNAI1 IGF1R KAT2B GNAI2 PPID CAV2 PRKCZ GNG3 HIST4H4 GNG2 GNG5 GNG4 GNG7 GNG8 DLAT HIST1H2BN HIST1H2BM HIST1H2BO NR1H2 HIST1H2BJ HDAC1 HIST1H2BI HIST1H2BL HIST1H2BK NR1H3 HIST2H4A HIST2H4B RARG RARA GTF2A1 RARB GTF2A2 TBL1X POLR2E POLR2F POLR2H POLR2K POLR2L TBL1XR1 KDM4A KDM4B RDH11 PIK3R3 KDM1A KDM1B CTSD CCND1 KAT5 FASN MMP2 MMP3 PDHB PCK1 UGT1A3 ESR1 KCTD6 APOC2 NCOA1 JUN SCD NCOA2 CREBBP NCOA3 MOV10 AGO3 AGO4 AGO1 RXRB AGO2 RXRA KDM3A PPARD PDK4 CDKN1B PDK3 AKT2 AKR1C3 FOXA1 AKT3 MYB PDK2 PGR PDK1 FKBP4 PDHX GATA3 XPO1 SRC CPT1A POU2F1 MMP9 CPT1B GREB1 CXCL12 AXIN1 CITED1 CHD1 NR5A2 PDPK1 AKT1 SPHK1 TFF1 KANK1 CXXC5 USF2 USF1 ZNF217 EBAG9 PRMT1 CBFB CRABP1 RUNX1 DHRS3 DHRS4 ALDH1A3 SDR16C5 DHRS9 ALDH1A2 PIK3R2 RDH10 RDH16 RDH5 RDH14 RDH13 ATF2 ALDH8A1 ELK1 NOS3 EP300 CAV1 PTK2 FOS ADH1C ADH1A KPNA2 CREB1 CCNT1 SP1 ZDHHC21 SRF MAPK1 CYP26A1 MAPK3 CYP26B1 JUND CYP26C1 PTGES3 FOSB HSP90AA1 MYLIP CDK9 ANGPTL3 ABCG1 CETP APOC4 MED1 APOC1 IMMUNE SYSTEM%REACTOME%R-HSA-168256.7 Immune System CUL1 DCTN4 KIF3A CDH1 IQGAP2 CAPZA3 KIF26A CAPZA1 CAPZA2 RAB18 ACTR10 PDXK ITCH UNC93B1 CTSV CNPY3 CTSS CTSL CTSK CTSB RNF213 FOXO1 CD86 LCK CD80 CD28 FOXO3 BCL2 IQGAP1 CYB5R3 SPRED3 SPRED2 SPRED1 SYNGAP1 HRAS RASA3 RASA4 RASA1 RASA2 CUL3 RASAL1 RASAL2 RASAL3 NRAS DAB2IP NF1 KBTBD7 ARF1 HEXB CFD CSH1 C3 RPLP0 GZMM PRL ECSIT CFB PRLR GHR GH2 GH1 ARG1 PTGS2 FABP5 RORA THEM4 PRDX6 KPNB1 MYC SKP2 PGLYRP4 PGLYRP3 PGLYRP2 LEAP2 HTN1 S100A7A HTN3 BPIFA1 GNLY BPIFA2 EPPIN DCD HSP90AB1 RNASE6 REG3A PIK3CD ITLN1 REG3G EPPIN-WFDC6 ART1 RNASE8 EGF SHC1 RNASE7 GAB1 PI3 PIK3R1 CHGA CBL DEFA6 EGFR DEFA5 NDUFC2 DEFA3 PIK3CA BPIFB2 PLCG1 BPIFB1 SOS1 BPIFB4 BPIFB6 SEMG1 PIK3C3 ATOX1 SEC23A TGFB1 SMURF1 MT2A RHOA FKBP1A IFNB1 VEGFA LY86 FCER1A MS4A2 CLEC10A TXK LPO EEA1 SEC24B RBSN HSPA6 TIFA SEC24A ALPK1 LAT2 PPAPDC1A PPAPDC1B CXCL8 CD180 CLEC4A CLEC4E CLEC7A SOD1 CLEC6A SEC24D SEC24C FGF6 FGF9 ARSA FGF20 FGF1 FGF2 KIR3DS1 FGF23 FGF3 TREM1 FGF22 SIRPB1 FGF10 CLEC5A FGF4 CD300LB SIGLEC15 SIGLEC14 KIR2DS2 KIR2DS4 NCR2 CD300E PIK3R4 BLNK PIK3R3 KIF5B ANPEP KIF5A CTSG CTSD MME ATP6AP2 ARSB CPB2 CTSA MYO5A RAB27A WASL CD36 CIITA IFI30 ICAM1 TRIM8 TRIM6 CD44 TRIM5 TRIM29 TRIM2 TRIM3 TRIM68 PRR5 TRIM26 CYFIP2 TRIM22 CYFIP1 NCKAP1 HLA-DPA1 GBP6 AHCYL1 GBP5 NCF1 TRIM62 NCF2 ITGB3 GBP7 NCF4 MID1 TRIM17 IRF4 BRK1 PIK3CB IRF1 IRF2 IRF8 AKT2 TRIM14 AKT3 IRF5 TREM2 KLRK1 MLST8 IRF6 TRIM10 GRAP2 IRF9 KLRC2 ITGAV TYROBP HLA-DQB2 LCP2 RAC1 HLA-DQB1 NCK1 SP100 KLRD1 PTAFR VAV3 TRIM46 PRKCB PDPK1 NCAM1 TRIM48 GBP2 CYBB FCGR1B CYBA VAV1 GBP1 HLA-DQA2 VAV2 GBP4 MAPKAPK3 HLA-DQA1 ACAA1 ELMO1 GBP3 ELMO2 TRIM45 TRIB3 HLA-DRB5 CRK VCAM1 DOCK1 HLA-DRB4 SHC2 ROCK1 TRIM35 HLA-DPB1 HLA-DRA MAPKAP1 TRIM38 TRIM31 HLA-DRB3 ITPR1 HLA-DRB1 ITPR2 TRIM34 ITPR3 PIK3R2 CDC42 PAK1 MRC2 PTK2B MRC1 RICTOR CD207 NCKAP1L FYN WASF1 PAK3 WASF2 PAK2 WASF3 JUP NOS3 BAIAP2 MTOR PTK2 MAPK12 MAPK13 ABI2 ABI1 CTNNB1 IFITM3 IFITM1 IFITM2 IFI35 IFIT3 IFIT2 RSAD2 BST2 IFNA5 IFNA4 IFNA7 IFNA6 IFNA1 IFNA2 IFNA8 IFI6 STAT2 IFNA13 IFNA14 IFNA16 IFNA17 SAMHD1 IFNA10 IFNAR1 IFNA21 CASP8 ISG20 XAF1 ADAR GLB1 FASLG RIPK1 TRAF2 FADD TNF RBCK1 VCP PRKCSH PSEN1 NCSTN MLEC PDIA3 PLCG2 CYLD RASGRF2 CANX TNFAIP3 CALR CASP3 TNFRSF1A TAX1BP1 SOS2 BIRC2 BIRC3 ASAH1 AOC1 LMNB1 AGL CAPN1 GYG1 AIP PSAP WIPF1 WIPF2 WIPF3 C3AR1 TXNIP MEFV GM2A ARPC1B ARPC1A IL18 IL1A IL1B WAS MYO9B ACTG1 PYCARD NCKIPSD NLRP3 ARPC4 ARPC5 ARPC2 ARPC3 PSTPIP1 ACTR3 ACTR2 PTPN13 MYH2 MYO10 MYO1C IMPDH1 SUGT1 IMPDH2 FRMPD3 GMFG ABCA13 PGLYRP1 PRSS2 NHLRC3 MCEMP1 ARMC8 RNASE3 RNASE2 SCAMP1 UNC13D FLG2 FPR1 A1BG FPR2 PLAC8 CRACR2A PRDX4 S100A11 GSDMD FUCA1 MAOA FUCA2 AZU1 MGST1 PA2G4 LYZ HRNR PIGR SERPINA3 SERPINA1 SIGLEC9 INPP5D MMP25 TIMP2 OLR1 SERPINB3 SERPINB1 AHSG NFAM1 TMC6 SERPINB6 PLEKHO2 SERPINB10 GRN SERPINB12 AGA METTL7A ERP44 LRG1 YPEL5 SIGLEC5 GHDC TMEM179B RAB3D HP EPX STK10 RAB44 LAMP1 GLIPR1 LAMP2 TOM1 KCMF1 IST1 OLFM4 ILF2 CLEC4C CLEC4D RAB31 RAB37 MANBA ADAM8 NME2 DSC1 S100A9 ARL8A S100A8 S100A7 AMPD3 RAB5B BRI3 UBR4 TRAPPC1 DEFA4 DEFA1 PTPRB PTPRC NIT2 FAM47E-STBD1 ITGAM ITGB2 LRMP ITGAL FCAR ITGAX RNASET2 DDOST PKM TMBIM1 BPI ACPP CANT1 FGL2 CECR1 RAB24 CPPED1 RAB10 NFASC TSPAN14 MNDA FOLR3 CALML5 LGALS3 TBC1D10C GOLGA7 C6orf120 ALDH3B1 SLC11A1 KRT1 MIF CD4 CHIT1 SLPI CD8B CRISPLD2 DOCK2 C16orf62 TMEM63A SYNGR1 COMMD9 MAN2B1 VAT1 PTPRN2 STK11IP PRG2 B4GALT1 NBEAL2 PRG3 PPBP SLC2A3 CYSTM1 ORM1 FAF2 HBB STUB1 MAGT1 FRK ORM2 ACTR1B NAPRT CTSH QSOX1 CTSC CD33 CAP1 GUSB CD53 FCER1G COMMD3 RAP2C CEACAM3 CEACAM1 RAP2B CEACAM6 CEACAM8 CD47 DNASE1L1 CD63 CSTB C1orf35 LILRA3 CST3 PGRMC1 TP53 CXCR1 CREG1 CXCR2 CD58 TXN LAIR1 GCA HUWE1 LILRB2 LILRB3 SVIP QPCT CD68 RAB9B FCN1 SRP14 MPO POMC JUN PLAU COTL1 SIRPA CREBBP ENPP4 OSTF1 CD93 CD300A ATAD3B OSCAR DOK3 ADGRG3 CNN2 SDCBP DPP7 MGAM AP1G1 GGH AP1S2 CDK13 DNAJC13 AP1B1 SELL AP1S1 TARM1 MS4A3 AP1S3 CDKN1A HLA-A DDX3X TNFAIP6 B2M AP1M2 CRISP3 AP1M1 CXCL1 SLC2A5 HEBP2 ADGRE5 ADGRE3 HGSNAT TICAM2 DYNLT1 LY96 MMP8 TICAM1 MMP9 CD14 CKAP4 CHI3L1 TLR4 LTF CLEC12A MVP MOSPD2 DEFA1B CASP10 TMEM30A CMTM6 PDAP1 GALNS PTX3 S100P ITGA2B ARAF PEBP1 ARRB2 KSR1 KSR2 TCEB2 TCEB1 APBB1IP CNKSR2 CNKSR1 VCL MRE11A RAP1B ATG7 MARK3 FN1 NFATC2 EIF4A2 CTLA4 EIF4A1 EIF4E3 UBE2L6 IFIT1 OASL LAMTOR2 HERC5 CSF2 TRIM25 LAMTOR1 KPNA7 KPNA4 LAMTOR3 ARIH1 KPNA5 KPNA2 IL2 KPNA3 JAK1 DDX58 IL2RA PPM1B OAS1 RAG2 IRF3 RAG1 PDE12 OAS2 OAS3 USP41 EIF4E2 RNASEL UBA7 USP18 FLNA FLNB EIF4E STAT1 MX2 MX1 FRS2 EIF2AK2 FRS3 ISG15 FGF16 NEDD4 UBE2N FGF7 FGF18 ABCE1 EIF4G3 EIF4G2 PDGFRA MAP2K6 CAB39 BCL6 HVCN1 PIN1 PTEN CASP1 CASP2 CXCL2 CCR6 APAF1 PPP2R5C CCR2 CCL11 CCL3L1 CCL3L3 BIRC5 APP CCL5 SNAP23 CCL4 CTSZ CCL3 RNF34 ARRB1 CCL2 CCL19 NLRC4 FTH1 SH3GL2 CCR1 CCL22 VAMP8 CCL20 VAMP7 CXCL10 FTL RAB5C PML STX4 TXNDC5 TRAF3 TLR3 LNPEP SEC61A2 FZR1 SEC61A1 SEC61G IGF2R SEC61B VAMP3 BTC EPGN TGFA AREG HBEGF EREG DEFB103A DEFB103B DEFB105A DEFB105B DEFB129 DEFB128 DEFB127 DEFB126 DEFB125 DEFB124 DEFB1 DEFB123 DEFB107A DEFB121 DEFB107B DEFB104B DEFB106B DEFB104A DEFB119 DEFB118 DEFB116 DEFB115 DEFB136 DEFB114 DEFB135 DEFB113 DEFB134 DEFB112 DEFB133 DEFB132 DEFB108B DEFB110 DEFB131 DEFB106A DEFB4A DEFB4B PROS1 RNF41 F13A1 PRCP CD177 FGB FGA VWF FBXO4 FBXO6 FGG F2 FBXW4 CDC34 FBXW5 CARD11 FBXW10 CD101 FBXW7 BCL10 FBXW9 VASP TRAV19 FBXW2 LAT ITK SERPING1 PTPN22 CD3E PRTN3 CD3D ENAH ZAP70 EVL MALT1 FYB TRAT1 FBXL3 FBXL5 CCT2 TCP1 CCT8 STAT3 TUBB4B IL7R DNM1 DNM3 ACTN2 KPNA1 GRIN2B GRIN2D PANX1 NEFL STIM1 DBNL ORAI2 ORAI1 LRRC7 CHRNB4 GRIN1 CLTC CLTA AP2A1 NOS1 AP2B1 AP2A2 AP2S1 TRPC1 AP2M1 SUMO1 CFL1 NF2 BLK LIMK1 DLG2 DLG3 RASGRF1 ICOSLG PDCD1LG2 CD274 BTLA PDCD1 RAB4B KCNAB2 HGF MET CRKL DNAJC5 IL1RAPL1 HSPA5 ERAP2 ERAP1 HLA-B TAP2 HLA-C EIF4A3 TAP1 HLA-F HLA-G HLA-E TAPBP SEC31A ITGB1 PTPRJ ANGPT1 TEK S100A1 LBP CAMK2B RAPGEF1 LAMA5 CAMK2D CAMK2A RANBP9 CAMK2G MUC20 PTPN2 DLG1 DLG4 IL23R IL27 IL27RA IL12B IL12A SERPINB2 IL23A BOLA2 SNRPA1 LCP1 RALA EBI3 BOLA2B HNRNPDL STAT4 IL12RB1 IL12RB2 MSN HNRNPF HNRNPA2B1 PDCD4 IL2RG SOCS2 JAK3 TSLP CISH IL7 CRLF2 DUSP5 DUSP2 DUSP1 DUSP8 DUSP9 DUSP16 DUSP10 PEA15 SNAP29 ACTR1A CEP290 PHB FBXW11 TUBB SOCS1 IFNG IFNGR1 IFNGR2 DYNLL1 PITPNA TANK DYNC1I2 DCTN2 DCTN3 HERC2 RNF111 DYNC1H1 PRKDC SPTAN1 RAB7A XRCC6 DSP XRCC5 DSG1 PKP1 PRKCQ PPP5C GSN VIM UBE2D2 UBE2D3 CUL2 NRTN GFRA1 SPTB GFRA2 GFRA4 SPTBN4 SPTBN5 SPTA1 SPTBN1 PIAS1 SPTBN2 PSPN GDNF PTPRA UBE2V2 PPIE ARTN CRCP IFIH1 DDX41 TBK1 RNF135 LRRFIP1 ABL1 MAVS TRIM21 SIKE1 UBE2B MB21D1 ZBP1 RIPK3 TMEM173 IRF7 TRIM56 DHX9 NLRC3 DTX4 IFI16 NLRP4 DHX36 STAT6 POLR3GL TREX1 POLR3A POLR3B POLR3C POLR3D POLR3E POLR3F POLR3G POLR3H POLR3K TRIM32 RNF4 RCHY1 MAPK8 EEF1A1 EEF2 CHUK CASP9 MKRN1 NOS2 HMHA1 RACGAP1 ARHGAP9 PPP2R5E GDI2 PPP2R5B PPP2R5A FGR PTPN11 RAC2 P2RX7 RHOG RHOF P2RX1 PTPN6 SMAD3 RHOU LRR1 CCNF KEAP1 CBLB UBE2L3 HERC4 HERC3 SMURF2 RNF115 RNF114 HERC1 FBXO7 FBXO9 KLB HERC6 FLT3 WSB1 PDE3B FBXO2 RNF123 FLT3LG RNF126 GAB2 HECW2 TRIM11 FGF19 ANAPC13 FGFR4 UBE2J2 UBE2J1 RNF217 HACE1 SIAH2 SIAH1 MEX3C UBAC1 FBXL8 FBXL4 DZIP3 RNF220 DET1 LRSAM1 SH3RF1 TRIM9 TRIM4 ARIH2 GPR75-ASB3 LRRC41 RNF144B GAN RNF138 RNF130 KLHL2 KLHL3 UBE2G1 UBE2G2 KLHL9 SPSB2 SPSB1 KBTBD6 KLHL5 RLIM TRIP12 KBTBD8 SPSB4 UBE2D4 UBE3C UBE3D MYLIP FBXO27 LTN1 RNF19B UBE3A UBE3B NPC2 FBXO21 UBE2Z FBXO22 PARK2 NPEPPS RNF19A FBXW12 AREL1 FBXW8 UBE2E3 FBXO17 UBE2E2 FBXO15 UBE4A MIB2 LMO7 FBXO10 P4HB FBXO11 KLHL41 TRAIP KLHL42 KCTD7 CUL5 UBA6 IRAK2 UBA5 TRAF6 KLHL11 TAB3 UBR2 TAB2 KLHL13 TAB1 MAP3K7 UBR1 FBXO44 FBXO41 FBXO40 BTBD1 LONRF1 UBE2F UBE2H KLHL25 ZBTB16 GLMN KLHL21 KLHL22 UBE2A BTBD6 FBXO30 KLHL20 FBXO31 UBE2W UBOX5 UBE2S UBE2U RNF182 UBE2O TPP2 BLMH UBA1 UBE2K TRIM71 RNF14 KBTBD13 UFL1 UBE2Q1 UBE2Q2 TRIM69 ZNF645 UNKL DTX3L PJA2 PJA1 TRAF7 UBE2R2 THOP1 TRIM50 MGRN1 IRAK3 TIRAP VPRBP ASB13 TLR1 SIGIRR ASB14 ASB11 TLR6 RNF6 TLR2 RNF7 ASB12 ASB17 ASB18 FBXL22 ASB15 ASB16 FBXL20 ZNRF1 ZNRF2 HECTD1 HECTD2 ASB10 HECTD3 RBBP6 TRIM41 RNF25 FBXL19 PPP3R1 FBXL15 SLCO4C1 FBXL16 FBXL13 FBXL14 FBXL12 TRIM39 BCL2L1 ASB8 ASB9 LNX1 ASB6 ASB7 TRIM36 TRIM37 PPIA ASB4 ASB5 ASB2 ASB1 TLR10 TLR5 PDGFRB KIT PDGFB PIK3AP1 IL21 IL21R SOX2 OTUD5 DHX58 ATG12 RNF125 NLRX1 NLRC5 RNF216 APEH PCBP2 ATG5 PPP3CA PPP3CB NFATC3 NFATC1 CRP PADI2 SMARCA4 TNFRSF6B TNFSF11 TNFRSF8 COLEC12 TNFRSF4 COLEC11 EDAR TNFRSF11B TNFRSF11A TNFRSF17 TNFRSF14 MASP1 TNFSF18 TNFSF14 TNFSF15 TNFSF12 JAK2 TNFRSF9 TNFSF4 UBA3 TNFSF9 CD27 TNFSF8 MAP3K14 UBE2M EDA TEC TNFRSF13B TNFRSF13C EDA2R TNFSF13B RELA EDARADD TNFRSF12A TNFRSF18 TNFRSF1B LTA TNFRSF25 LTB RELB CD70 CD40LG LTBR CCND1 DIAPH1 CASP4 AIM2 NLRP1 CARD9 KCTD6 NFKB1 NFKB2 BRWD1 RAB6A GATA3 POU2F1 CCR5 CXADR TREML1 TREML4 TREML2 REL CD200R1 HCST HLA-DMA HLA-DMB KIR3DL1 KIR3DL2 SIGLEC1 SIGLEC8 SIGLEC7 SIGLEC6 HLA-DOA HLA-DOB LAG3 BTN1A1 CLEC4G RAP1GAP CD300LD CD300LF CD300LG BTN2A2 CD160 BTN2A1 ITGB7 PIANP ITGA4 RILP CLEC2B FCGR2B CLEC2D PVRL2 ICAM2 ICAM3 ICAM4 ICAM5 CD226 CD1D CD1C PPL CD1B CD1A CD79B CD79A SLAMF7 SLAMF6 SIGLEC12 SIGLEC11 SH2D1A SIGLEC10 SH2D1B SLC15A4 PILRB PILRA RAET1E CD209 CD200 CD22 CTSO CTSF CTSE BTN3A1 BTN3A3 BTN3A2 NCR1 NCR3 LILRA6 LILRA1 LILRA2 LILRA4 LILRA5 NCR3LG1 LAIR2 MICA MICB NPDC1 CD74 LILRB1 LILRB4 LILRB5 SIPA1 PVR CD96 CD8A KLRF1 CD300C KLRB1 DAPP1 KIR2DL1 KIR2DL2 RASGRP2 KIR2DL3 RASGRP1 KIR2DL4 RASGRP3 KLRC1 IGHG4 CD99 BTNL9 RAP1GAP2 IGHG1 BTNL8 CRTAM IGHG2 IGKV1-12 BTNL2 NFKBIE ULBP1 ULBP3 AMICA1 KLRG1 ADAM17 IGKV2D-28 IGKV4-1 IGKV2D-30 GPR84 ITGB5 IGKV3-11 LYN YES1 IL6 ANXA1 CD3G ANXA2 FCGR3A IGKV2-28 IL10 SYK IGKV3D-20 HCK IL4 IL18RAP IL37 IL13 IL18R1 IL18BP MYH9 HSP90B1 FCGR1A IGKV5-2 FCGR2A WDR83 PAQR3 BRAP RET GFRA3 IL17RD RAPGEF2 IL5RA SHC3 RASGRP4 IL5 MAP3K11 RASGEF1A IL3RA IL2RB MUC12 MUC13 MUC15 MUCL1 MUC3A MUC5AC CUL7 DCTN1 CFP MUC1 MUC7 MUC4 MUC6 MUC17 MUC5B MUC21 DNAJC3 TLN1 ATP6V0D1 MAP2K1 MAP2K2 BRAF RAF1 IL20RA IL20RB IL22RA2 IL22RA1 TIMP1 HAVCR2 ZEB1 STX3 IL10RB IL10RA CSF3 CSF3R CSF1 RORC PIM1 IL13RA2 IL13RA1 TXLNA FSCN1 CSF1R NDN SOCS5 MCL1 CEBPD PTPRZ1 LGALS9 IL15RA STXBP2 TWIST1 IFNLR1 GRB2 IL22 IL20 IL25 IL26 CSF2RB IL24 IL15 CSF2RA IL19 IL16 IL17RE IL17RC IL17RB TCIRG1 IL17RA IGHE OPRD1 ATP6V1E1 IL32 ATP6V1E2 IL34 ATP6V1G1 BATF IL17F ATP6V0B ATP6V0E1 IL17C ATP6V1G2 IL17A IL4R IL9 MMP1 MMP2 ATP6V1B2 MMP3 OPRM1 IL9R ATP6V0C ATP6V0D2 IFNL2 ATP6V1B1 IFNL1 ATP6V1A S1PR1 IFNL3 CAND1 ATP6V0A2 ATP6V1H ATP6V0A4 ATP6V0E2 ATP6V1G3 ATP6V1D ATP6V1C1 ATP6V1F ATP6V0A1 ATP6V1C2 CD81 C4BPA C4BPB LCN2 C8B C8A CLU C4B C4A C8G CR2 CR1 CD46 C1QB C1QA C1S CFH C1R C5AR2 C5AR1 CFI C4B_2 CPN2 CPN1 C2 VTN C5 C6 C7 C9 CD19 CD59 ELANE CD55 CFHR2 CFHR1 CFHR4 CFHR3 CFHR5 C1QC SNAP25 IL3 RAB3A NANOG STX1A VAMP2 COL1A2 CDC20 DYNC1LI1 CPNE1 DYNC1LI2 CPNE3 DGAT1 DSN1 KIF18A CSNK2B DYNLL2 PLD4 KIF2A PLD1 KIF2C PLA2G6 KIF2B PLD3 PLD2 DYNC1I1 CENPE SLC44A2 LPCAT1 AGPAT2 PLA2G2A HSPA9 SOD2 NFKBIA IKBKG IKBKE VHL ANAPC7 UBE2C UBE2E1 STAT5A UBE2D1 STAT5B ANAPC10 ANAPC11 SOCS3 IRS1 CDC23 CDC26 IRS2 CDC27 CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 GPI NUP107 NUP188 HK3 PPP2R1B PPP2R1A PRKACG NUP62 PRKACA PRKACB NDC1 NUP214 SAR1B SEC13 NUP133 NUP210 PGAM1 PPP2R5D FCGR3B LTA4H NUP93 NUP50 PLAUR NUP54 ALDOC ALDOA LGMN POM121 NUP205 AAAS NUP160 PPP2CA PPP2CB NUP85 TPR NUP88 NUP43 RAE1 RANBP2 NUP155 NUP153 PFKL GSTO1 NUP35 NUPL2 NUP37 RAPGEF3 RAPGEF4 GSTP1 ATF1 ACLY ATF2 SLC27A2 ELK1 RPS6KA3 RPS6KA5 RPS6KA2 RPS6KA1 EP300 JUNB DUSP4 TKFC MEF2A MEF2C DUSP3 RAP1A FOS VRK3 DUSP6 DNM2 DUSP7 IP6K2 CREB1 MAPKAPK2 HPSE MAPK7 MAPK1 OSBPL1A MAPK3 EGR1 ALAD MAPK14 MAPK11 PGM2 PGM1 HSP90AA1 ERBB2 TALDO1 NEU1 APOB BST1 SDC1 GAA APRT PDZD11 ORMDL3 XDH INPPL1 DEGS1 CA1 FCN2 FCN3 COLEC10 MBL2 ACTB GLA HIST2H3A CDA HIST2H3D PRSS3 HIST2H3C MTAP HIST1H3J HIST1H3A HIST1H3F HIST1H3G HIST1H3H HIST1H3I HIST1H3B HIST1H3C GNS HIST1H3D HIST1H3E ATP8A1 HMOX1 ATP11B ATP11A HMOX2 TCN1 NEDD4L PYGB TRPM2 PYGL ATP8B4 ALOX5 POLR1C TRIM63 ATP7A CAT RETN ANO6 FBXO32 POLR2E POLR2F POLR2H STOM POLR2K POLR2L WWP1 IL1RN IL36A IL36B IL1R1 IL1R2 IL36RN IL36G IL1F10 TOLLIP PTPN20 PTPN23 IL1RL1 IL1RL2 MAP3K3 IL33 PTPN18 PTPN14 PTPN9 PTPN7 PTPN4 PTPN5 HMGB1 IKBKB FCER2 NKIRAS1 NKIRAS2 MAP3K8 TTR MAP2K3 MAP2K4 RIPK2 IRAK4 PELI1 TLR9 TLR8 TLR7 UBE2V1 PELI3 PELI2 NOD1 NOD2 AGER MAPK9 IRAK1 RAB14 VAPA S100A12 MAP2K7 MAP3K1 S100B MAPK10 TNIP2 SAA1 MYD88 NFKBIB FBXL7 PNP FBXL18 YWHAB PRKCE PSMD8 PSMD9 PSMD6 SH3KBP1 SRC PSMD7 PSMD4 CSK PSMD5 PSMD2 AAMP PSMD3 PAG1 AKT1 ADAM10 PSMD1 PTPN12 PRKCD YWHAZ PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 UBA52 DERA PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 VNN1 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 UBB PSMB3 UBC PSMB1 PSMF1 RPS27A HSPA8 SHFM1 TNFSF13 PSMB8 PSMB9 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 EIF4G1 NRG1 NRG2 NRG3 PTGES2 KIFAP3 NRG4 KIF20A HIF1A COPB1 PTPN1 KLC1 GSTA2 KLC4 KLC3 KLC2 KIF3B KIF3C SURF4 KIF4B KIF4A KIF11 KIF15 IL11 ALOX15 CAPZB CNTFR CNTF IL31 CTF1 IL11RA IDH1 LIF OSM IL31RA LIFR TYK2 KIF23 KIF22 OSMR CLCF1 IL6ST IL6R CRLF1 BTRC SKP1 BTK RBX1 SEC22B SQSTM1 PAFAH1B2 DCTN6 DCTN5 METABOLISM OF RNA%REACTOME%R-HSA-8953854.4 Metabolism of RNA RPS4X RPS3A CPSF4 CPSF7 CPSF1 CSTF3 CPSF3 CSTF2 CPSF2 CSTF2T WDR33 NUDT21 FIP1L1 APOBEC1 PABPN1 CLP1 APOBEC3C PCF11 APOBEC2 PAPOLA APOBEC4 CSTF1 APOBEC3H A1CF SYMPK APOBEC3A DDX5 APOBEC3B RQCD1 NCBP1 NCBP2 SUPT5H GTF2F1 GTF2F2 POLR2A POLR2B POLR2C POLR2D POLR2G POLR2I POLR2J GEMIN2 PHAX SNRPD2 SNRPD1 SNRPD3 CLNS1A SNRPG GEMIN4 GEMIN5 SNRPE GEMIN6 GEMIN7 SNRPF GEMIN8 SNRPB DDX20 SMN2 SMN1 SNUPN RPLP1 RPLP0 TRMT112 TFB1M RPLP2 RPS27L RPL22L1 XRN2 HBS1L TTC37 WDR61 NT5C3B DCPS SKIV2L NOP2 PCBP2 WDR77 HSD17B10 NOP56 RNMT RNGTT RPL23A NUP107 NUP188 PPP2R1A NUP62 NDC1 NUP214 SEC13 NUP133 NUP210 NUP93 NUP50 NUP54 EPRS ADARB1 POM121 NUP205 AAAS NUP160 PPP2CA NUP85 NSUN4 TPR RNMTL1 MTERF4 RPL27A NUP88 FTSJ2 MRM1 NUP43 RAE1 RANBP2 NUP155 NUP153 NUP35 NUPL2 NUP37 POP5 POP7 POP1 POP4 RRP1 TSEN54 ALKBH8 RRP9 LSM10 LSM11 WDR75 QTRTD1 GTPBP3 KIAA1456 RRP7A PNO1 TBL3 LAS1L MAPKAPK2 TRMU WDR46 WDR43 RIOK2 RIOK1 WDR36 NSUN2 TEX10 NSUN6 NXT1 DIEXF EIF4A3 GNL3 CASC3 GLE1 C14orf166 ZNF473 MAGOH URM1 THOC1 NIP7 THOC3 TSR3 THOC2 MAPK14 NOC4L THOC5 EXOSC10 THOC7 MAPK11 RRP36 CDC40 PAIP1 THOC6 TRMT10A SRRM1 DDX39A UTP6 DDX39B UTP3 ZC3H11A RIOK3 SARNP WDR18 ADAT1 SRSF2 TRMT1 SRSF3 WDR12 SRSF4 ADAT2 SRSF5 ADAR BYSL SRSF6 TRMT6 SRSF7 TSR1 SLU7 RAN TSEN2 SRSF9 THG1L FYTTD1 RPL26L1 RPL4 EDC3 LUZP4 EDC4 RBM8A RPL5 FTSJ1 POLDIP3 RPL30 FTSJ3 SRSF1 RPL3 EBNA1BP2 U2AF1 RPL32 NCL U2AF1L4 RPL31 ISG20L2 NXF1 THADA NXF2 RPL34 NOP14 U2AF2 RPL8 LSM1 DHX38 RPL9 SRSF11 WDR3 RPL6 CHTOP WDR4 RPL7 UPF3B MTO1 MAGOHB NOB1 RPL36 PATL1 NXF2B QTRT1 RNPS1 C1D LAGE3 RPL35 IGF2BP3 RPL38 IGF2BP2 RPL37 DCAF13 RPL39 NOP58 KRR1 TPRKB TRIT1 TRMT61A RPL21 TRMT61B RPL23 LTV1 RTCB RPL22 FCF1 THUMPD1 PWP2 TRMT44 METTL1 IMP3 IMP4 CIRH1A OSGEP RPL24 PDCD11 RPL27 ERI1 DHX37 RPL26 WBSCR22 C2orf49 RPL29 TRMT13 MPHOSPH10 RPL28 TRMT11 NOL11 NOL12 DCP1B ZCCHC11 ZBTB8OS NAT10 UTP14A UTP14C DUS2 CTU2 CTU1 RPL41 HEATR1 NOL9 NOL6 RPL3L PES1 BOP1 XPOT MPHOSPH6 RPP30 FBL RPP38 PDCD7 PUS3 HNRNPU DIMT1 CWC25 CDKAL1 HNRNPR UTP11L CWC27 PUS7 SNRPA1 CCAR1 RPP21 EFTUD2 RPP25 CWC22 DDX6 TXNL4A ZCCHC6 SNRNP35 DDX1 SRRM2 EMG1 SNRPN UTP20 ZCRB1 RPP40 WBP11 RCL1 CRNKL1 PAN2 HNRNPF PRPF4 PAN3 HNRNPA2B1 PRPF6 RBM28 HNRNPUL1 DDX49 PRPF3 TSEN15 SNRNP27 DDX47 CD2BP2 UTP15 PPIH DDX52 SNRNP25 SENP3 SNRNP200 UTP18 SNRPC TSEN34 SNRPA BMS1 SF1 RPL10 RPP14 RNPC3 RPL12 TRDMT1 RPL11 PRPF8 FAM98B PCBP1 ZMAT5 RPS3 ZRSR2 PRPF38A RPL14 RPL13 FUS CWC15 RPS2 LSM5 RPL15 LSM4 RPL18 LSM3 RPL17 LSM2 RPL19 CHERP HNRNPL LSM8 HNRNPM LSM7 LSM6 HNRNPK HNRNPD HNRNPC SUGP1 DDX46 DDX42 PPWD1 USP39 ELAVL2 PQBP1 PTBP1 SART1 SNRNP70 DHX15 DHX16 CTNNBL1 BCAS2 RBM5 RBM17 BUD31 PRPF40A TFIP11 RPS9 PLRG1 GCFC2 RPS7 RPS8 NHP2L1 RPS5 SYF2 RPS6 HNRNPH1 HNRNPH2 RPSA DNAJC8 SKIV2L2 RBM22 SF3B4 SF3B5 SF3B2 SF3B3 SF3B6 CSNK1D DDX23 WBP4 CSNK1E PRCC SRRT PUF60 TRA2B SNRPB2 HNRNPA1 SMNDC1 SRSF10 HNRNPA0 SF3A3 SF3A1 HNRNPA3 PPIL1 SF3A2 GPKOW CDC5L U2SURP SNRNP40 PHF5A PRPF31 SNRNP48 PPIL3 RBMX PPIL4 PPIL6 AQR RPL7A TGS1 CCNH METTL3 SLBP RPL37A METTL14 WTAP RPL36A RPL35A PRPF19 RPS4Y2 RPS4Y1 CDK7 XAB2 MNAT1 SNW1 RPL39L PPIE RPS15A DHX9 ISY1 DDX21 RPL10L RPL10A POLR2E POLR2F POLR2H SF3B1 FAU POLR2K POLR2L GTF2H1 DKC1 GTF2H2 NHP2 GTF2H3 GTF2H4 GAR1 GTF2H5 NOP10 ERCC3 ERCC2 TP53RK RPL13A YBX1 RPS15 RPS14 RPS17 RPS16 RPS19 RPL18A RPL36AL RPS18 RPS11 YWHAB RPS10 HSPB1 RPS13 ELAVL1 PSMD8 PSMD9 RPS12 PSMD6 XPO1 PSMD7 PSMD4 PSMD5 PSMD2 KHSRP PSMD3 AKT1 PSMD1 TNPO1 TNKS1BP1 DIS3 PRKCD PRKCA PRMT5 YWHAZ PSMA5 CNOT6L PSMA6 PSMA3 PSMA4 PSMA1 XRN1 PSMA2 PSME3 PSME4 PSME1 PSME2 PABPC1 UBA52 DCP2 RPS26 PSMD10 PSMB11 RPS25 PSMD12 SET PPP2R2A RPS28 GSPT2 PSMD11 GSPT1 RPS27 PSMD14 UPF3A ANP32A SMG1 PSMD13 SMG9 RPS29 PARN SMG7 PSMA7 SMG8 RPS20 PSMB10 SMG5 PSMA8 RPS21 SMG6 RPS24 ZFP36L1 UPF2 RPS23 EXOSC7 UPF1 PSMB6 ETF1 EXOSC6 PSMB7 PNRC2 EIF4A2 EIF4A1 EXOSC5 PSMB4 EXOSC4 PSMB5 PSMB2 UBB PSMB3 EXOSC9 EXOSC8 UBC PSMB1 PSMF1 EXOSC3 RPS27A EXOSC2 EXOSC1 HSPA8 SHFM1 TNFSF13 PSMB8 PSMB9 PSMC5 PSMC6 PSMC3 PSMC4 IGF2BP1 PSMC1 PSMC2 DCP1A EIF4G1 PELP1 EIF4E TRMT10C ELAC2 TRNT1 KIAA0391 EIF4B CNOT10 CNOT4 CNOT6 CNOT7 CNOT11 CNOT1 CNOT2 CNOT3 CNOT8 TYW5 TRMT5 TYW3 TYW1 TRMT12 LCMT2 RESOLUTION OF D-LOOP STRUCTURES THROUGH SYNTHESIS-DEPENDENT STRAND ANNEALING (SDSA)%REACTOME%R-HSA-5693554.1 Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) EXO1 RTEL1 WRN RMI2 DNA2 RMI1 TOP3A RAD51D BRIP1 BARD1 XRCC2 XRCC3 MRE11A RAD51AP1 RAD51 RBBP8 ATM BRCA2 PALB2 RAD51B KAT5 RAD50 RAD51C BRCA1 NBN BLM DEFECTIVE CSF2RA CAUSES PULMONARY SURFACTANT METABOLISM DYSFUNCTION 4 (SMDP4)%REACTOME%R-HSA-5688890.1 Defective CSF2RA causes pulmonary surfactant metabolism dysfunction 4 (SMDP4) SFTA3 SFTPB SFTPA2 SFTPC SFTPD CSF2RB SFTPA1 CSF2RA GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT%REACTOME DATABASE ID RELEASE 72%72706 GTP hydrolysis and joining of the 60S ribosomal subunit RPL26 RPL29 RPL10L RPS4X RPL10A RPL28 RPS3A RPL23A FAU RPL41 RPL3L RPL10 RPL12 RPL13A RPL11 RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL27A RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS15 RPS14 RPS17 RPS16 RPS19 RPL18A RPL36AL RPS18 RPLP1 RPS11 RPS10 RPLP0 RPS13 RPS12 RPLP2 RPL7A RPS27L UBA52 RPL37A RPS26 RPS25 RPS28 EIF1AX RPS27 RPL36A RPS29 EIF2S2 RPS20 RPL35A EIF2S1 RPS21 EIF5 RPS24 EIF2S3 RPS23 EIF5B EIF4A2 EIF4H EIF4A1 EIF3M EIF3K EIF3L RPL22L1 EIF3I EIF3J EIF3G EIF3H EIF3E EIF3F EIF3C EIF3D EIF3A RPS4Y2 EIF3B RPS4Y1 RPS27A EIF4G1 EIF4E RPL26L1 RPL4 RPL39L RPL5 RPL30 RPL3 RPL32 RPL31 EIF4B RPL34 RPL8 RPL9 RPL6 RPL7 RPL36 RPL35 RPL38 RPL37 RPL39 RPS15A RPL21 RPL23 RPL22 RPL24 RPL27 IKBKB DEFICIENCY CAUSES SCID%REACTOME%R-HSA-5602636.1 IKBKB deficiency causes SCID IKBKB CHUK IKBKG NECTIN NECL TRANS HETERODIMERIZATION%REACTOME DATABASE ID RELEASE 72%420597 Nectin Necl trans heterodimerization PVRL1 CADM3 CADM1 PVRL2 PVRL4 PVR PVRL3 CD22 MEDIATED BCR REGULATION%REACTOME%R-HSA-5690714.2 CD22 mediated BCR regulation IGKV3-11 IGKV1-12 LYN CD79B CD79A IGKV2D-28 IGKV4-1 PTPN6 IGKV2-28 IGKV2D-30 CD22 IGKV5-2 IGKV3D-20 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES%REACTOME%R-HSA-1650814.3 Collagen biosynthesis and modifying enzymes PCOLCE2 COL17A1 COL18A1 COL15A1 COL16A1 COL13A1 COL14A1 COL11A1 COL11A2 COL12A1 COL19A1 COL10A1 COL28A1 COL26A1 COL27A1 COL24A1 COL25A1 COL22A1 COL23A1 COL1A1 COL3A1 COL2A1 COL1A2 COL4A2 COL5A1 COL4A1 COL6A2 COL7A1 COL4A4 P3H2 COL5A3 P3H1 COL5A2 P3H3 COL6A1 COL4A3 COL8A2 COL4A6 SERPINH1 COL9A1 COL20A1 COL21A1 COL6A3 COL4A5 COL8A1 COL9A3 COL6A6 COL9A2 COL6A5 PLOD3 PLOD2 PLOD1 ADAMTS2 ADAMTS3 PCOLCE PPIB ADAMTS14 CRTAP P4HA1 P4HA2 P4HB P4HA3 COLGALT2 BMP1 COLGALT1 TLL2 TLL1 TOLERANCE BY MTB TO NITRIC OXIDE PRODUCED BY MACROPHAGES%REACTOME DATABASE ID RELEASE 72%1222538 Tolerance by Mtb to nitric oxide produced by macrophages TRNA PROCESSING IN THE NUCLEUS%REACTOME%R-HSA-6784531.5 tRNA processing in the nucleus C2orf49 ZBTB8OS NUP107 NUP188 CPSF4 CPSF1 XPOT CSTF2 RPP30 RPP38 NUP62 CLP1 NDC1 NUP214 SEC13 RPP21 RPP25 NUP133 POP5 NUP210 DDX1 POP7 POP1 POP4 RPP40 TSEN54 NUP93 NUP50 TSEN15 NUP54 TSEN34 RPP14 FAM98B POM121 NUP205 AAAS NUP160 C14orf166 NUP85 TPR NUP88 NUP43 ELAC2 TRNT1 RAE1 RANBP2 NUP155 NUP153 RAN TSEN2 NUP35 NUPL2 NUP37 RTCB ER QUALITY CONTROL COMPARTMENT (ERQC)%REACTOME%R-HSA-901032.5 ER Quality Control Compartment (ERQC) RNF139 OS9 UGGT2 UGGT1 EDEM3 EDEM1 AMFR EDEM2 SYVN1 MARCH6 UBB RNF103 UBC TRIM13 MAN1B1 RNF185 RPS27A UBA52 SEL1L DERL2 RNF5 KETONE BODY CATABOLISM%REACTOME%R-HSA-77108.4 Ketone body catabolism ACAT1 BDH1 OXCT1 OXCT2 KERATAN SULFATE KERATIN METABOLISM%REACTOME%R-HSA-1638074.1 Keratan sulfate keratin metabolism ST3GAL4 ST3GAL6 ST3GAL1 ST3GAL2 ST3GAL3 B4GALT6 B4GALT4 SLC35D2 B4GALT5 KERA FMOD GLB1 PRELP CHST6 LUM CHST1 B4GALT2 B4GALT3 B4GALT1 CHST5 CHST2 HEXB HEXA GNS B4GAT1 OMD OGN B3GNT7 B3GNT4 B3GNT3 B3GNT2 GLB1L CHOLESTEROL BIOSYNTHESIS%REACTOME%R-HSA-191273.4 Cholesterol biosynthesis IDI1 DHCR7 IDI2 TM7SF2 MVD MSMO1 MVK FDFT1 LSS NSDHL SQLE LBR ARV1 HMGCS1 GGPS1 HSD17B7 CYP51A1 EBP ACAT2 DHCR24 SC5D PMVK FDPS PPAPDC2 DEFECTIVE CFTR CAUSES CYSTIC FIBROSIS%REACTOME DATABASE ID RELEASE 72%5678895 Defective CFTR causes cystic fibrosis PSMD3 OS9 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 RNF185 UBA52 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 UBB PSMB3 UBC PSMB1 PSMF1 RPS27A SHFM1 PSMB8 PSMB9 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 ERLIN1 ERLIN2 DERL3 ERLEC1 CFTR PSMD8 VCP PSMD9 PSMD6 PSMD7 SEL1L PSMD4 DERL1 PSMD5 DERL2 PSMD2 RNF5 TGFBR1 LBD MUTANTS IN CANCER%REACTOME%R-HSA-3656535.1 TGFBR1 LBD Mutants in Cancer TGFB1 TGFBR1 TGFBR2 FKBP1A APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS%REACTOME DATABASE ID RELEASE 72%174143 APC C-mediated degradation of cell cycle proteins PSMD3 CUL1 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 BUB1B CCNA2 CCNA1 UBA52 CDC20 PSMD10 PTTG1 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 ANAPC15 AURKB ANAPC16 AURKA PSMB6 ANAPC7 PSMB7 UBE2C PLK1 UBE2E1 PSMB4 UBE2D1 ANAPC10 PSMB5 ANAPC11 PSMB2 CCNB1 UBB CDC23 PSMB3 CDC26 CDC27 UBC CDC16 PSMB1 CDK1 ANAPC4 PSMF1 ANAPC5 ANAPC1 RPS27A CDC14A ANAPC2 SHFM1 PSMB8 FBXO5 PSMB9 SKP2 PSMC5 PSMC6 PSMC3 PSMC4 BUB3 PSMC1 PSMC2 FZR1 MAD2L1 NEK2 CDK2 BTRC SKP1 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 DISEASES OF SIGNAL TRANSDUCTION BY GROWTH FACTOR RECEPTORS AND SECOND MESSENGERS%REACTOME DATABASE ID RELEASE 72%5663202 Diseases of signal transduction by growth factor receptors and second messengers BAG4 NCSTN OS9 CUL1 CAMK2D BCL2L11 CAMK2A APH1B SYVN1 CAMK2G PPP2R5C PSENEN FIP1L1 FOXO6 ARRB1 FOXO4 CSNK1A1 NR4A1 RPS6KB2 CTBP1 AP3B1 ADAM17 FGFR1 FOXO1 NCBP1 NCBP2 CD86 LCK CD80 GTF2F1 CD28 GTF2F2 POLR2A POLR2B GOLGA4 POLR2C FOXO3 PORCN POLR2D ETV6 POLR2G CUX1 POLR2I POLR2J IQGAP1 RNF43 WNT3A FZD4 FZD6 LRP5 FZD8 LRP6 SPRED3 PHB SPRED2 SPRED1 HRAS BTC EPGN TGFA AREG NRAS HBEGF EREG NF1 AKAP9 AGK PDGFRB CDK8 KIT PDGFB ESR2 STRN PIK3AP1 FGFR1OP HHAT SHH DHH IHH KRAS FGB FGA VWF STAT5A WDR48 STAT5B DKK1 FGG DKK2 IRS1 DKK4 IRS2 BRAP KREMEN1 KREMEN2 MYC TRAT1 NOTCH1 MAP3K11 MAML2 MAML1 RBPJ HES1 PIK3CD GSK3B SNW1 EGF SHC1 MAML3 GAB1 PIK3R1 CBL EGFR MAMLD1 PIK3CA PLCG1 SOS1 NCOR2 NCOR1 HDAC3 TGFB1 SMAD4 HDAC10 LMNA LRRFIP1 KAT2B KAT2A TGFBR1 PAPSS1 TGFBR2 FKBP1A HDAC2 STAT3 HDAC1 TLN1 TBL1X MAP2K1 MAP2K2 BRAF RAF1 POLR2E POLR2F POLR2H POLR2K POLR2L JAK2 CCNC FGF6 FGF9 PPP2R1B TBL1XR1 PPP2R1A FGF20 FGF1 FGF2 FGF23 CLCN6 FGF3 FGF22 FGF10 FGF4 PPP2R5D PIK3R3 CPSF6 ZMYM2 FGFR1OP2 MYO18A TNKS TNKS2 PPP2CA PPP2CB GSK3A CHUK BAD CASP9 TCF7L2 FGFR3 ESR1 FGFR2 CREBBP BCR PRR5 KDM7A FZD5 CDKN1A ITGB3 HDAC8 CD19 CDKN1B PIK3CB YWHAB AKT2 PSMD8 AKT3 PSMD9 MLST8 PSMD6 KDR SRC PSMD7 PSMD4 RAC1 AMER1 PSMD5 AXIN1 CSK PSMD2 PPP2R5E PSMD3 PDPK1 AKT1 PSMD1 KANK1 ADAM10 VAV1 PPP2R5B PTPN12 PPP2R5A PTPN11 RAC2 PSMA5 PSMA6 RHOG PSMA3 PSMA4 PSMA1 ITGA2B ARAF PSMA2 PEBP1 PSME3 MAPKAP1 ARRB2 PSME4 KIAA1549 MPRIP PSME1 TRIM24 PSME2 SMAD2 KSR1 UBA52 AGTRAP SMAD3 PIK3R2 KSR2 SND1 PSMD10 APBB1IP PSMB11 CNKSR2 PSMD12 CNKSR1 RICTOR PSMD11 PAPD7 PSMD14 ESRP1 VCL FYN FAM114A2 PSMD13 ZC3HAV1 APC TRAK1 PSMA7 FXR1 PSMB10 PSMA8 RAP1B ATG7 MARK3 FN1 PSMB6 EP300 QKI PSMB7 MTOR FAM131B AGGF1 HGF PSMB4 MET RAP1A PSMB5 PSMB2 KLB CTBP2 UBB PSMB3 CTNNB1 UBC GAB2 PSMB1 PSMF1 FGF19 CREB1 FGFR4 RPS27A SHFM1 PSMB8 PSMB9 PSMC5 MAPK1 PSMC6 PSMC3 MAPK3 PSMC4 PSMC1 PSMC2 TSC2 STAT1 NRG1 ERLIN2 NRG2 FRS2 FGF16 NRG3 FGF7 NRG4 FGF18 PDGFRA ERLEC1 ERBB2IP HSP90AA1 CDC37 ERBB2 HDAC11 HEY1 HEY2 AKT1S1 HDAC4 HDAC5 DLL1 HDAC9 HDAC6 HDAC7 DLL4 NEURL1B HES5 JAG2 JAG1 MDM2 MIB2 MIB1 HEYL NEURL1 SKP1 VCP RBX1 PSEN2 PTEN SEL1L PSEN1 DERL2 APH1A CAMK2B PI AND PC TRANSPORT BETWEEN ER AND GOLGI MEMBRANES%REACTOME%R-HSA-1483196.2 PI and PC transport between ER and Golgi membranes PITPNB DCC MEDIATED ATTRACTIVE SIGNALING%REACTOME DATABASE ID RELEASE 72%418885 DCC mediated attractive signaling TRIO PTK2 DOCK1 WASL DCC NTN1 CDC42 SRC ABLIM1 RAC1 ABLIM2 NCK1 ABLIM3 HDL REMODELING%REACTOME DATABASE ID RELEASE 72%8964058 HDL remodeling ALB APOC3 ABCG1 CETP APOA1 LCAT LIPG APOC2 APOE PHENYLALANINE METABOLISM%REACTOME DATABASE ID RELEASE 72%8964208 Phenylalanine metabolism ASRGL1 QDPR IL4I1 PCBD1 PAH CCBL1 UNCOATING OF THE HIV VIRION%REACTOME%R-HSA-162585.1 Uncoating of the HIV Virion PPIA BIOSYNTHESIS OF MARESIN-LIKE SPMS%REACTOME DATABASE ID RELEASE 72%9027307 Biosynthesis of maresin-like SPMs CYP3A4 CYP2C9 CYP1A2 CYP2C8 CYP2D6 CYP2E1 RESOLUTION OF SISTER CHROMATID COHESION%REACTOME%R-HSA-2500257.1 Resolution of Sister Chromatid Cohesion PPP1CC NUP107 PPP2R5C ERCC6L ZWILCH BUB1B CASC5 SMC3 CDC20 PPP2R1B PPP2R1A KNTC1 DYNC1LI1 BIRC5 DYNC1LI2 CLIP1 ZW10 MAD1L1 CDCA5 CDCA8 SEC13 PDS5B PDS5A PMF1 NUP133 SKA1 AURKB SKA2 DSN1 RAD21 PPP2R5D RCC2 NDC80 ZWINT STAG1 KIF18A STAG2 SGOL2 SGOL1 NUF2 WAPAL SPDL1 NDEL1 NUDC SMC1A DYNLL2 KIF2A INCENP KIF2C KIF2B ITGB3BP MIS12 CENPA NSL1 NUP160 CENPC PPP2CA BUB3 PPP2CB BUB1 NUP85 DYNC1I1 CLASP2 CENPT CENPU NUP43 CENPE CENPF CENPH CENPI TAOK1 RANBP2 CENPK CENPL CENPM CENPN B9D2 CENPO CENPP CENPQ SPC24 MAD2L1 SPC25 NUP37 DYNLL1 CKAP5 MAPRE1 PAFAH1B1 XPO1 DYNC1I2 CCNB2 PPP2R5E PPP2R5B PPP2R5A CLASP1 DYNC1H1 NDE1 RPS27 PLK1 CCNB1 CDK1 APITD1 AHCTF1 RANGAP1 BIOSYNTHESIS OF MARESIN CONJUGATES IN TISSUE REGENERATION (MCTR)%REACTOME%R-HSA-9026762.1 Biosynthesis of maresin conjugates in tissue regeneration (MCTR) LTC4S GSTM4 KINESINS%REACTOME DATABASE ID RELEASE 72%983189 Kinesins KIF3A CENPE KIF21A KIF21B KIFAP3 KIF26A KIF26B KIF16B KIF20A KIF20B KLC1 KLC4 KLC3 KLC2 KIF3B KIF3C KIF18B KIF4B KIF4A KIF11 KIF15 KIF19 KIF13B KIF5B KIF1C KIF1B KIF5A KIF1A KIF18A KIF25 RACGAP1 KIF23 KIF22 KIF6 KIF27 KIF9 KIFC2 KIF2A KIFC1 KIF2C KIF2B DEFECTIVE SLC35C1 CAUSES CONGENITAL DISORDER OF GLYCOSYLATION 2C (CDG2C)%REACTOME DATABASE ID RELEASE 72%5619078 Defective SLC35C1 causes congenital disorder of glycosylation 2C (CDG2C) SLC35C1 MEIOSIS%REACTOME DATABASE ID RELEASE 72%1500620 Meiosis RPA1 RPA2 HSPA2 RPA3 TERF2IP SMC3 RAD21 RAD51 PRDM9 RBBP8 STAG1 STAG2 HIST3H3 SMC1A RAD50 LMNB1 CDK4 MSH4 MSH5 FKBP6 SYCE3 SYCE2 SYCE1 STAG3 SYCP2 SYCP1 SPO11 SYNE2 SYNE1 ATM SUN2 UBE2I SUN1 TEX12 TEX15 ATR SMC1B DMC1 PSMC3IP MND1 REC8 MLH3 SYCP3 BRCA1 TINF2 TOP3A HIST1H2AE HIST1H2AD HIST3H2BB HIST1H2AC ACD HIST1H2AB HIST1H2AJ MRE11A HIST2H3A HIST1H2BF MLH1 HIST1H2BE HIST1H2BH HIST1H2BG HIST2H3D HIST1H2BB HIST1H2BA HIST2H3C HIST1H2BD HIST1H2BC H2AFB1 BRCA2 HIST1H3J HIST1H3A HIST1H3F HIST1H3G HIST1H3H HIST1H3I TERF1 HIST1H3B TERF2 HIST1H3C HIST1H3D HIST1H3E H3F3B RAD51C NBN HIST1H4K POT1 HIST1H4L H3F3A H2BFS HIST1H4A HIST1H4B HIST1H4H HIST1H4I HIST1H4J HIST1H4C HIST1H4D HIST1H4E HIST1H4F HIST2H2AA3 HIST2H2AA4 HIST2H2AC H2AFJ H2AFZ H2AFX H2AFV HIST2H2BE HIST4H4 CDK2 HIST1H2BN HIST1H2BM HIST1H2BO HIST1H2BJ HIST1H2BI HIST1H2BL HIST1H2BK HIST2H4A BLM HIST2H4B CYTOSOLIC SULFONATION OF SMALL MOLECULES%REACTOME%R-HSA-156584.3 Cytosolic sulfonation of small molecules SULT1A1 SULT1C2 PAPSS2 SULT1A4 PAPSS1 SULT1A3 SULT1A2 SULT2A1 IMPAD1 SULT1C4 SULT4A1 SLC26A2 PODXL2 SLC26A1 TPST2 BPNT1 SULT1B1 TPST1 ABHD14B SULT1E1 SULT6B1 SLC35B3 SLC35B2 TICAM1, RIP1-MEDIATED IKK COMPLEX RECRUITMENT%REACTOME DATABASE ID RELEASE 72%168927 TICAM1, RIP1-mediated IKK complex recruitment IKBKB CHUK UBE2D1 RIPK3 UBE2N BIRC2 BIRC3 UBB UBE2V1 UBC RPS27A UBA52 RIPK1 TRAF6 UBE2D2 TICAM1 UBE2D3 IKBKG TLR3 CELLULAR RESPONSES TO STRESS%REACTOME DATABASE ID RELEASE 72%2262752 Cellular responses to stress DCTN4 RPS4X RPS3A CAPZA3 GPX2 CAPZA1 CAPZA2 ACTR10 CCNA2 CCNA1 TFDP1 TFDP2 DYNC1LI1 DYNC1LI2 E2F1 BMI1 RNF2 CBX8 PHC2 PHC1 RING1 TXNRD1 CBX4 CBX2 DYNLL2 TNRC6C PHC3 RAD50 TNRC6A TNRC6B DYNC1I1 FZR1 E2F2 E2F3 RPLP1 RPLP0 RPLP2 HSPA9 RPS27L SOD2 VHL AR ANAPC15 ATF5 ANAPC16 ATF3 ANAPC7 ASF1A UBE2C SEH1L NPRL2 UBE2E1 HSPA4L RPL22L1 UBE2D1 NPRL3 ANAPC10 ANAPC11 PRDX3 HSPH1 WDR59 CDC23 ST13 CDC26 EIF2AK1 CDC27 EIF2AK4 CDC16 PRDX6 NOX4 ANAPC4 NOX5 ANAPC5 MIOS ANAPC1 CRYAB ANAPC2 HSPA14 HSPA13 RB1 WDR24 C11orf73 UBN1 CDKN2D CDKN2B CDKN2C GATSL3 HSPA1L EPO SESN1 MAP3K5 ERF TNIK FKBP5 STIP1 BAG5 BAG2 HSP90AB1 BAG3 BAG1 IGFBP7 C7orf60 HIF1AN GPX3 GPX6 GPX5 GPX8 GPX7 DNAJC2 IMPACT ARNT DNAJC7 PPP1R15A CEBPB CEBPG DNAJB6 GCN1L1 SH3BP4 FNIP1 FNIP2 ATOX1 DNAJA1 DNAJA4 DNAJA2 NUDT2 CCAR2 C12orf66 HSPA12A HSPA12B VENTX MINK1 ITFG2 KPTN DEPDC5 HIRA STAT3 MAP4K4 IFNB1 VEGFA ETS1 ETS2 NR3C2 GATSL2 SZT2 RPS19BP1 HIGD1A CBX6 RPA1 HSPA4 RPA2 HSPA6 HMGA2 HSPA2 RPA3 CXCL8 HSPB8 RPL23A CABIN1 FLCN SOD3 SOD1 CCS NUP107 NUP188 HMGA1 NUP62 NDC1 NUP214 RELA SEC13 NUP133 NUP210 ERO1L NUP93 NUP50 NUP54 POM121 NUP205 AAAS NUP160 NUP85 TPR RPL27A NUP88 NUP43 RAE1 RANBP2 EP400 NUP155 HSBP1 NFKB1 HSF1 NUP153 CDK4 NUP35 NUPL2 NUP37 KDM6B NCF1 NCF2 NCF4 GSTP1 PGR MLST8 FKBP4 CYBB CYBA MAPKAPK3 TRIB3 CDK6 ATF2 RPS6KA3 RPS6KA2 RPS6KA1 EP300 MTOR FOS MAPKAPK2 SP1 HSPA5 MAPK7 MAPK1 MAPK3 MAPK14 MAPK11 ID1 RPL26L1 RPL4 RPL5 HSP90AA1 RPL30 RPL3 RPL32 RPL31 RPL34 RPL8 RPL9 RPL6 RPL7 RPL36 RPL35 RPL38 RPL37 RPL39 RPL21 RPL23 RPL22 VCP RPL24 RPL27 CAMK2B RPL26 BAG4 CAMK2D RPL29 CAMK2A RPL28 CAMK2G RPL41 RPL3L RPL10 RPL12 RPL11 RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 LMNB1 IL6 TXN2 ACTR1A RPS9 RPS7 RPS8 RPS5 RPS6 RPSA DDIT3 DYNLL1 ATF4 AJUBA ASNS DYNC1I2 DCTN2 DCTN3 CA9 RPL7A TINF2 DYNC1H1 GPX1 IL1A EHMT2 RPL37A HIST1H1D HIST1H1E HIST1H2AE HIST1H2AD HIST3H2BB HIST1H1A ACD HIST1H2AC HIST1H1B HIST1H2AB HIST1H1C RPL36A HIST1H2AJ RPL35A HIST2H3A EIF2S2 HIST1H2BF EIF2S1 HIST1H2BE HIST1H2BH EIF2S3 HIST1H2BG HIST2H3D HIST1H2BB HIST1H2BA HIST2H3C HIST1H2BD HIST1H2BC H2AFB1 H1F0 HIST1H3J HIST1H3A HIST1H3F CHAC1 HIST1H3G HIST1H3H RPS4Y2 HIST1H3I RPS4Y1 TERF1 TERF2 HIST1H3B HIST1H3C HIST1H3D HIST1H3E H3F3B POT1 HIST1H4K UBE2D2 UBE2D3 HIST1H4L H3F3A HIF3A LIMD1 CUL2 H2BFS EGLN1 HIST1H4A EGLN3 EGLN2 HIST1H4B WTIP HIST1H4H HIST1H4I HIST1H4J HIST1H4C HIST1H4D HIST1H4E EZH2 HIST1H4F HIST2H2AA3 GSK3B HIST2H2AA4 HIST2H2AC RPL39L H2AFJ DCTN1 EED H2AFZ H2AFX H2AFV SIRT1 HIST2H2BE HIST4H4 RPS15A HIST1H2BN HIST1H2BM HIST1H2BO ATP7A HIST1H2BJ CAT HIST1H2BI HIST1H2BL HIST1H2BK HIST2H4A HIST2H4B ATP6V0D1 RBBP4 RPL10L RPL10A RBBP7 TERF2IP FAU SUZ12 MAPK8 HIST3H3 EHMT1 TCIRG1 RPL13A ATP6V1E1 KAT5 ATP6V1E2 ATP6V1G1 ATP6V0B ATP6V0E1 ATP6V1G2 EEF1A1 ATP6V1B2 RRAGA ATP6V0C ATP6V0D2 ATP6V1B1 RRAGC ATP6V1A MAP2K3 MAP2K4 RRAGB RRAGD ATP6V1H TP53 ATP6V0E2 ATP6V1G3 ATP6V1D TXN ATP6V1C1 PRDX2 ATP6V1F ATP6V1C2 MAPK9 PRDX1 MAP2K7 MAPK10 JUN CREBBP MOV10 AGO3 CITED2 AGO4 AGO1 RPS15 RPS14 RPS17 ATM RPS16 RPS19 RPL18A ATR CDKN1A RPL36AL RPS18 CDKN1B RPS11 RPS10 RPS13 PSMD8 PSMD9 RPS12 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 RPTOR PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 UBA52 RPS26 TCEB2 PSMD10 TCEB1 PSMB11 RPS25 PSMD12 RPS28 PSMD11 RPS27 PSMD14 PSMD13 CDKN2A RPS29 PSMA7 MRE11A RPS20 PSMB10 PSMA8 RPS21 RPS24 RPS23 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 LAMTOR2 UBB PSMB3 LAMTOR1 LAMTOR4 GRB10 LAMTOR3 LAMTOR5 UBC PSMB1 PSMF1 RPS27A HSPA8 SHFM1 SESN2 PSMB8 NBN PSMB9 PSMC5 PSMC6 PSMC3 DNAJB1 PSMC4 PSMC1 AQP8 PSMC2 NR3C1 CCNE2 CCNE1 MAPKAPK5 PTGES3 EPAS1 HIF1A SLC38A9 MAP2K6 AKT1S1 CAPZB HDAC6 RHEB CDK2 MDM2 CYCS P4HB MDM4 YWHAE RBX1 DCTN6 DCTN5 SUMO IS PROTEOLYTICALLY PROCESSED%REACTOME%R-HSA-3065679.2 SUMO is proteolytically processed SUMO2 SENP5 SENP2 SENP1 SUMO1 SUMO3 PROCESSING OF DNA DOUBLE-STRAND BREAK ENDS%REACTOME DATABASE ID RELEASE 72%5693607 Processing of DNA double-strand break ends EXO1 WHSC1 RPA1 RPA2 TOPBP1 WRN RPA3 DNA2 RFC5 RFC3 RFC4 RFC2 RNF8 RNF4 CCNA2 CCNA1 RBBP8 BRE HIST3H3 MDC1 KAT5 RAD50 CHEK1 HUS1 RHNO1 BRIP1 ATRIP BARD1 RAD17 ATM UBE2I ATR BRCA1 SUMO1 SUMO2 HERC2 PPP4R2 TIPIN RMI2 RMI1 TOP3A PIAS4 UBA52 BRCC3 PPP4C TP53BP1 HIST3H2BB MRE11A HIST1H2BF HIST1H2BE HIST1H2BH HIST1H2BG HIST1H2BB HIST1H2BA HIST1H2BD HIST1H2BC UBB RAD1 BABAM1 UIMC1 UBC SIRT6 RPS27A RNF168 NBN HIST1H4K HIST1H4L H2BFS HIST1H4A HIST1H4B HIST1H4H HIST1H4I HIST1H4J HIST1H4C HIST1H4D HIST1H4E UBE2N HIST1H4F TIMELESS UBE2V2 H2AFX HIST2H2BE CLSPN HIST4H4 CDK2 HIST1H2BN HIST1H2BM RAD9B HIST1H2BO RAD9A HIST1H2BJ FAM175A HIST1H2BI HIST1H2BL HIST1H2BK HIST2H4A BLM HIST2H4B PINK PARKIN MEDIATED MITOPHAGY%REACTOME DATABASE ID RELEASE 72%5205685 Pink Parkin Mediated Mitophagy MFN1 VDAC1 ATG5 MFN2 TOMM70A PARK2 TOMM7 TOMM5 TOMM6 MTERF3 UBB MAP1LC3B UBC MAP1LC3A RPS27A UBA52 ATG12 SQSTM1 TOMM20 TOMM40 TOMM22 PINK1 TRANSPORT OF CONNEXONS TO THE PLASMA MEMBRANE%REACTOME%R-HSA-190872.1 Transport of connexons to the plasma membrane GJA1 GJB2 DEFECTIVE CYP11B1 CAUSES ADRENAL HYPERPLASIA 4 (AH4)%REACTOME DATABASE ID RELEASE 72%5579017 Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4) CYP11B1 CLEC7A (DECTIN-1) SIGNALING%REACTOME%R-HSA-5607764.1 CLEC7A (Dectin-1) signaling PSMD3 PDPK1 CUL1 PSMD1 PRKCD PSMA5 PSMA6 PLCG2 PSMA3 PSMA4 CLEC7A PSMA1 PSMA2 PSME3 IL1B PSME4 PSME1 PSME2 ITPR1 ITPR2 UBA3 UBA52 ITPR3 PYCARD PSMD10 PSMB11 MAP3K14 PSMD12 UBE2M PSMD11 PSMD14 NFKBIA IKBKG PSMD13 RELA PSMA7 PSMB10 PSMA8 PSMB6 RELB PSMB7 NFATC2 PSMB4 UBE2D1 PSMB5 PSMB2 UBB PSMB3 CDC34 CARD11 UBC BCL10 PSMB1 PSMF1 RPS27A SHFM1 PSMB8 UBE2D2 PSMB9 MALT1 PSMC5 PSMC6 PSMC3 PPP3R1 PSMC4 PSMC1 PSMC2 IKBKB CHUK CARD9 UBE2N UBE2V1 CASP8 NFKB1 NFKB2 SYK FBXW11 PPP3CA PPP3CB NFATC3 NFATC1 AHCYL1 BTRC SKP1 PSMD8 PSMD9 TRAF6 PSMD6 TAB3 TAB2 PSMD7 TAB1 PSMD4 MAP3K7 PSMD5 PSMD2 GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION%REACTOME DATABASE ID RELEASE 72%163841 Gamma carboxylation, hypusine formation and arylsulfatase activation EIF5A2 PROZ BGLAP SUMF2 EIF5A SUMF1 FN3K ICMT DHPS FN3KRP DOHH GGCX GAS6 ARSA PROS1 DPH1 DPH2 DPH3 DPH5 DPH6 F10 DPH7 F2 F7 ARSJ STS ARSK ARSH PROC ARSI F9 ARSF ARSG ARSD ARSE FURIN ARSB EEF2 PYRIMIDINE CATABOLISM%REACTOME DATABASE ID RELEASE 72%73621 Pyrimidine catabolism UPP2 AGXT2 NT5M UPP1 UPB1 DPYD TYMP NT5C NT5C1A NT5E DPYS INTERLEUKIN-17 SIGNALING%REACTOME DATABASE ID RELEASE 72%448424 Interleukin-17 signaling CUL1 MAP2K1 MAPKAPK3 UBA52 MAPK8 PPP2R1B ATF1 PPP2R1A ATF2 IKBKG ELK1 RPS6KA3 RPS6KA5 RPS6KA2 RPS6KA1 DUSP4 PPP2R5D MEF2A MEF2C DUSP3 IL25 FOS VRK3 UBB DUSP6 IL17RE DUSP7 UBC IL17RC IL17RB CREB1 IL17RA MAPKAPK2 RPS27A IL17F IL17C MAPK7 IL17A MAPK1 MAPK3 PPP2CA PPP2CB IKBKB MAPK14 MAP3K8 MAP2K3 CHUK MAPK11 MAP2K4 RIPK2 UBE2N UBE2V1 NOD1 NFKB1 NOD2 MAPK9 IRAK1 MAP2K6 MAP2K7 MAPK10 TNIP2 JUN FBXW11 BTRC SKP1 IRAK2 TRAF6 TAB3 TAB2 TAB1 MAP3K7 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE%REACTOME%R-HSA-168138.1 Toll Like Receptor 9 (TLR9) Cascade EEA1 CUL1 RBSN MAP2K1 MAPKAPK3 UBA52 MAPK8 PPP2R1B ATF1 PPP2R1A APP ATF2 NFKBIA IKBKG ELK1 RELA RPS6KA3 RPS6KA5 RPS6KA2 RPS6KA1 DUSP4 PPP2R5D PIK3R4 MEF2A MEF2C DUSP3 FOS VRK3 UBB DUSP6 DUSP7 UBC CREB1 MAPKAPK2 RPS27A MAPK7 MAPK1 MAPK3 PPP2CA HMGB1 PPP2CB IKBKB NKIRAS1 NKIRAS2 MAPK14 MAP3K8 MAP2K3 CHUK MAPK11 MAP2K4 RIPK2 IRAK4 PELI1 UBE2N TLR9 TLR8 TLR7 UBE2V1 PELI3 PELI2 NOD1 NFKB1 NOD2 NFKB2 AGER MAPK9 IRAK1 MAP2K6 S100A12 MAP2K7 MAP3K1 S100B MAPK10 TNIP2 JUN SAA1 PIK3C3 MYD88 NFKBIB FBXW11 IRF7 BTRC ECSIT SKP1 IRAK2 TRAF6 TICAM2 TAB3 LY96 TAB2 TICAM1 TAB1 MAP3K7 CD14 TLR4 LAGGING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 72%69186 Lagging Strand Synthesis LIG1 RPA1 RPA2 POLD3 RFC1 POLD4 RPA3 POLD1 POLA1 POLD2 RFC5 POLA2 DNA2 RFC3 RFC4 RFC2 PRIM2 PRIM1 FEN1 PCNA REGULATION OF THE APOPTOSOME ACTIVITY%REACTOME DATABASE ID RELEASE 72%9627069 Regulation of the apoptosome activity APIP CARD8 CASP9 AVEN MAPK1 APAF1 DIABLO XIAP UACA MAPK3 CYCS NEUROTRANSMITTER UPTAKE AND METABOLISM IN GLIAL CELLS%REACTOME DATABASE ID RELEASE 72%112313 Neurotransmitter uptake and metabolism In glial cells SLC1A2 SLC1A3 GLUL SLC38A1 RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF HSCS%REACTOME%R-HSA-8939236.1 RUNX1 regulates transcription of genes involved in differentiation of HSCs ITCH KMT2A TP73 PSMD8 MYB PSMD9 PSMD6 GATA3 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 CBFB PSMA2 RUNX1 PSME3 CCNH PSME4 PSME1 PSME2 UBA52 PSMD10 HIST1H2AE PSMB11 HIST1H2AD PSMD12 HIST3H2BB HIST1H2AC PSMD11 HIST1H2AB PSMD14 HIST1H2AJ PSMD13 PSMA7 SPI1 HIST2H3A PSMB10 HIST1H2BF PSMA8 HIST1H2BE HIST1H2BH GATA2 HIST1H2BG GATA1 PSMB6 HIST2H3D HIST1H2BB PSMB7 HIST1H2BA HIST2H3C TAL1 PSMB4 HIST1H2BD YAP1 HIST1H2BC TCF12 PSMB5 H2AFB1 PSMB2 UBB LMO1 HIST1H3J PSMB3 LMO2 HIST1H3A UBC HIST1H3F HIST1H3G PSMB1 HIST1H3H PSMF1 HIST1H3I TCF3 RPS27A HIST1H3B LDB1 HIST1H3C HIST1H3D HIST1H3E SHFM1 H3F3B HIST1H4K PSMB8 PSMB9 HIST1H4L PSMC5 H3F3A PSMC6 PSMC3 H2BFS PSMC4 HIST1H4A PSMC1 CDK7 PSMC2 HIST1H4B HIST1H4H HIST1H4I HIST1H4J HIST1H4C MNAT1 HIST1H4D HIST1H4E HIST1H4F HIST2H2AA3 HIST2H2AA4 HIST2H2AC H2AFJ H2AFZ H2AFX H2AFV ABL1 HIST2H2BE HIST4H4 HIST1H2BN HIST1H2BM HIST1H2BO HIST1H2BJ HIST1H2BI HIST1H2BL HIST1H2BK HIST2H4A HIST2H4B SIGNALING BY MEMBRANE-TETHERED FUSIONS OF PDGFRA OR PDGFRB%REACTOME DATABASE ID RELEASE 72%9673768 Signaling by membrane-tethered fusions of PDGFRA or PDGFRB KANK1 GOLGA4 ETV6 KDR SIGNALING BY ERBB2 IN CANCER%REACTOME DATABASE ID RELEASE 72%1227990 Signaling by ERBB2 in Cancer HRAS NRG1 PTPN12 NRG2 BTC NRG3 NRG4 NRAS HBEGF EREG EGF SHC1 GAB1 PIK3R1 EGFR PIK3CA PLCG1 SOS1 ERBB2IP HSP90AA1 CDC37 ERBB2 SIGNALING BY ACTIVIN%REACTOME%R-HSA-1502540.2 Signaling by Activin ACVR1C SMAD4 INHBB INHBA SMAD2 SMAD3 FST FOXH1 ACVR1B ACVR2B ACVR2A FSTL3 DRAP1 ECM PROTEOGLYCANS%REACTOME%R-HSA-3000178.3 ECM proteoglycans NCAM1 LAMA5 LRP4 LAMA2 LAMA1 LAMA4 LAMA3 ITGAX LAMB2 LAMB1 ITGA2B SPARC DMP1 LUM MUSK COL9A1 ITGA9 COL9A3 PTPRS COL9A2 SERPINE1 HSPG2 MATN1 MATN4 MATN3 TNXB ITGB5 DSPP TNC COMP DAG1 IBSP TNN FMOD TNR TGFB1 TGFB2 TGFB3 BCAN VTN VCAN ITGB3 NCAN ITGB1 BGN HAPLN1 DCN LAMC1 ITGB6 ITGAV ASPN ITGA2 ITGA8 AGRN ITGA7 MEIOTIC RECOMBINATION%REACTOME%R-HSA-912446.2 Meiotic recombination RPA1 RPA2 RPA3 TOP3A HIST1H2AE HIST1H2AD HIST3H2BB HIST1H2AC HIST1H2AB HIST1H2AJ MRE11A HIST2H3A HIST1H2BF MLH1 HIST1H2BE HIST1H2BH HIST1H2BG HIST2H3D HIST1H2BB RAD51 PRDM9 HIST1H2BA RBBP8 HIST2H3C HIST1H2BD HIST1H2BC BRCA2 H2AFB1 HIST3H3 HIST1H3J HIST1H3A HIST1H3F HIST1H3G HIST1H3H HIST1H3I HIST1H3B HIST1H3C HIST1H3D RAD50 HIST1H3E RAD51C H3F3B NBN HIST1H4K HIST1H4L H3F3A H2BFS HIST1H4A HIST1H4B HIST1H4H HIST1H4I HIST1H4J HIST1H4C HIST1H4D HIST1H4E HIST1H4F HIST2H2AA3 HIST2H2AA4 HIST2H2AC CDK4 H2AFJ H2AFZ MSH4 MSH5 H2AFX H2AFV HIST2H2BE SPO11 ATM HIST4H4 CDK2 TEX15 DMC1 PSMC3IP HIST1H2BN MND1 HIST1H2BM MLH3 HIST1H2BO HIST1H2BJ HIST1H2BI HIST1H2BL BRCA1 HIST1H2BK HIST2H4A BLM HIST2H4B LOCALIZATION OF THE PINCH-ILK-PARVIN COMPLEX TO FOCAL ADHESIONS%REACTOME DATABASE ID RELEASE 72%446343 Localization of the PINCH-ILK-PARVIN complex to focal adhesions PXN ITGB1 ILK ACETYLATION%REACTOME%R-HSA-156582.1 Acetylation NAT1 NAT2 HCMV INFECTION%REACTOME%R-HSA-9609646.2 HCMV Infection RBBP4 TBL1X HIST2H2AB RBBP7 NUP107 NUP188 SUZ12 TBL1XR1 DYNC1LI1 HIST2H2BF DYNC1LI2 NUP62 NDC1 NUP214 SEC13 CEBPD NUP133 NUP210 HIST3H2A NUP93 TRIM28 NUP50 NUP54 HIST1H2AG HIST1H2AA HIST1H2AM DYNLL2 PML HIST1H2AL GPS2 HIST1H2AI HIST1H2AH POM121 HIST1H2AK NUP205 DAXX AAAS NUP160 NUP85 DYNC1I1 TPR NUP88 NUP43 HNRNPK RAE1 RANBP2 CHMP2A NUP155 NFKB1 NUP153 NUP35 NUPL2 NUP37 DYNLL1 DYNC1I2 TSG101 VPS4A MVB12B MVB12A VPS36 DYNC1H1 VPS37C VPS37D VPS37A SNF8 VPS37B CHMP2B CHMP4C UBAP1 CHMP4B CHMP3 CHMP4A HIST1H2AE CHMP6 HIST1H2AD VPS25 HIST3H2BB HIST1H2AC CHMP7 HIST1H2AB VPS28 HIST1H2AJ ELK1 HIST2H3A HIST1H2BF HIST1H2BE HIST1H2BH HIST1H2BG HIST2H3D HIST1H2BB CBX1 HIST1H2BA CHMP1A HIST2H3C HIST1H2BD HIST1H2BC HIST1H3J HIST1H3A HIST1H3F HIST1H3G HIST1H3H CREB1 HIST1H3I HIST1H3B HIST1H3C HIST1H3D HIST1H3E HIST1H4K HIST1H4L HIST1H4A HIST1H4B HIST1H4H HIST1H4I HIST1H4J HIST1H4C HIST1H4D HIST1H4E EZH2 HIST1H4F HIST2H2AA3 HIST2H2AA4 HIST2H2AC EGFR EED NCOR2 NCOR1 HDAC3 HIST2H2BE HIST4H4 HIST1H2BN ITGB1 HIST1H2BM HIST1H2BO HIST1H2BJ HIST1H2BI HIST1H2BL HIST1H2BK HIST2H4A HIST2H4B TRKA ACTIVATION BY NGF%REACTOME DATABASE ID RELEASE 72%187042 TRKA activation by NGF NTRK1 NGF MAPK FAMILY SIGNALING CASCADES%REACTOME%R-HSA-5683057.3 MAPK family signaling cascades CAMK2D CAMK2A RANBP9 CAMK2G RASGRF2 PPP2R5C DLG1 DLG4 RASGRP1 RASGRP3 ARRB1 IL2RG JAK3 TNRC6C FOXO1 TNRC6A DUSP5 TNRC6B DUSP2 DUSP1 DUSP8 FOXO3 DUSP9 IL6 DUSP16 DUSP10 PEA15 IQGAP1 SPRED3 PHB SPRED2 SPRED1 SYNGAP1 HRAS RASA3 RASA4 RASA1 RASA2 CUL3 BTC RASAL1 EPGN RASAL2 TGFA RASAL3 AREG NRAS HBEGF DAB2IP EREG NF1 KBTBD7 PDGFRB KIT PDGFB SPTAN1 PPP5C FGB FGA VWF FGG IRS1 IRS2 CDK1 WDR83 PAQR3 BRAP RET GFRA3 IL17RD MYC RAPGEF2 IL5RA SHC3 RASGRP4 IL5 MAP3K11 RASGEF1A IL3RA IL2RB NRTN GFRA1 SPTB EGF GFRA2 SHC1 GFRA4 SPTBN4 SPTBN5 EGFR SPTA1 SOS1 SPTBN1 SPTBN2 PSPN GDNF PTPRA ARTN TLN1 MAP2K1 MAP2K2 BRAF RAF1 JAK2 ACTN2 FGF6 FGF9 PPP2R1B PPP2R1A FGF20 PRKACG FGF1 FGF2 PRKACA FGF23 PRKACB FGF3 FGF22 FGF10 FGF4 PPP2R5D GRIN2B GRIN2D CSF2RB CSF2RA PPP2CA PPP2CB NEFL LRRC7 JUN NCOA3 MOV10 AGO3 AGO4 AGO1 AGO2 GRIN1 ITGB3 YWHAB HSPB1 PSMD8 PSMD9 PSMD6 XPO1 SRC PSMD7 PSMD4 RAC1 PSMD5 IL3 CSK PSMD2 PPP2R5E PSMD3 NCAM1 PSMD1 PPP2R5B PPP2R5A PTPN11 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 ITGA2B SHC2 ARAF PSMA2 PEBP1 PSME3 CCND3 ARRB2 PSME4 DLG2 PSME1 PSME2 DLG3 KSR1 UBA52 RASGRF1 KSR2 PSMD10 CDC42 APBB1IP PAK1 PSMB11 CNKSR2 PSMD12 CNKSR1 PSMD11 PSMD14 VCL FYN PSMD13 PAK3 PSMA7 PAK2 PSMB10 PSMA8 RAP1B MARK3 FN1 PSMB6 DUSP4 PSMB7 PTK2 HGF PSMB4 MET RAP1A PSMB5 PSMB2 LAMTOR2 KLB CSF2 UBB FLT3 PSMB3 DUSP6 LAMTOR3 FLT3LG DUSP7 UBC PSMB1 PSMF1 IL2 FGF19 FGFR4 JAK1 RPS27A CDC14A CDC14B IL2RA SEPT7 RAG2 SHFM1 RAG1 PSMB8 ETV4 CDC42EP5 PSMB9 CDC42EP3 PSMC5 MAPK1 CDC42EP2 PSMC6 PSMC3 DNAJB1 MAPK3 PSMC4 IGF2BP1 PSMC1 MAPK6 PSMC2 MAPK4 NRG1 NRG2 FRS2 FRS3 FGF16 NRG3 FGF7 MAPKAPK5 NRG4 FGF18 PDGFRA ERBB2 TYK2 IL6R ANGPT1 RBX1 TEK KALRN CAMK2B PURINE CATABOLISM%REACTOME%R-HSA-74259.3 Purine catabolism GDA NUDT16 NT5C2 NUDT15 GPX1 PNP NUDT5 NT5C1A ADPRM DNPH1 NT5C1B ITPA XDH NT5C NT5E ASPARAGINE N-LINKED GLYCOSYLATION%REACTOME DATABASE ID RELEASE 72%446203 Asparagine N-linked glycosylation RNF139 OS9 RAB1B MLEC DCTN4 UGGT2 NEU2 UGGT1 NEU3 PDIA3 EDEM3 EDEM1 ARCN1 NEU1 CAPZA3 AMFR EDEM2 SYVN1 MOGS CAPZA1 CAPZA2 MARCH6 B4GALNT2 RAD23B RNF103 CANX COPG2 TRIM13 COPG1 NSF CALR ACTR10 MAN1B1 RNF185 ENGASE DYNC1LI1 DYNC1LI2 ARF4 CTSZ NAPA DYNLL2 SLC35A1 SLC35C1 NAPB GOSR1 NAPG GBF1 DYNC1I1 GOLGA2 MAN2A2 MAN1A2 GOLGB1 MAN2A1 MAN1C1 STX5 MAN1A1 YKT6 COG8 COG7 COG6 COG5 COG4 COG3 ACTR1A COG2 COG1 BET1L DPAGT1 MPI ALG8 ALG9 ALG6 ALG14 ALG3 CSNK1D ALG13 TGFA ALG12 ALG1 AREG ALG11 DYNLL1 DHDDS ARF3 MPDU1 NUS1 ARF1 PMM2 DOLK RFT1 MGAT2 DYNC1I2 DCTN2 DCTN3 DYNC1H1 SPTAN1 F5 F8 ST3GAL4 SRD5A3 ST3GAL6 CGA ST3GAL1 FUCA1 ST3GAL2 ST3GAL3 TRAPPC4 SERPINA1 SPTB SPTBN4 SPTBN5 SPTA1 SPTBN1 SPTBN2 DCTN1 TFG LMAN1L GOSR2 LMAN2L UMOD ST6GALNAC6 SCFD1 CHST10 MIA2 SEC23A MIA3 ASGR1 ASGR2 CHST8 STX17 USO1 LMAN1 LMAN2 MGAT5 MGAT3 MGAT1 TRAPPC10 SEC23IP GFPT1 TUSC3 MANEA TRAPPC2L TBC1D20 ARFGAP1 FUT8 TRAPPC2 ANKRD28 TRAPPC3 SEC16B SEC16A PREB TRAPPC5 TRAPPC9 TRAPPC1 CNIH1 KDELR3 TMEM115 STT3A CNIH2 CNIH3 MCFD2 SEC24B PPP6C PPP6R1 SEC24A PPP6R3 TRAPPC6A TRAPPC6B ANK2 DAD1 GORASP1 ANK3 SEC22A DDOST SEC22C MGAT4C MGAT4A MGAT4B FOLR1 BET1 SEC24D SEC24C SAR1B SEC13 B4GALT2 B4GALT3 B4GALT1 DPM1 DPM2 MAGT1 DPM3 CTSC CTSA B4GALT6 B4GALT4 B4GALT5 ST6GALNAC1 GMPPB FPGT ST6GALNAC2 CMAS GMPPA NPL PGM3 NANP GNPNAT1 NEU4 NUDT14 ALG5 ST8SIA4 TMED2 RPN2 SLC17A5 ALG10 RPN1 ST8SIA5 RENBP ALG10B ST3GAL5 TSTA3 ST8SIA6 NANS UAP1 ST6GAL1 FUOM ST6GAL2 GMDS ST8SIA1 AMDHD2 ALG2 ST8SIA2 FUK PMM1 ST8SIA3 GFPT2 ST6GALNAC3 ST6GALNAC4 NAGK ST6GALNAC5 DOLPP1 GNE CD59 CD55 LHB FUT3 UBA52 COL7A1 UBB UBC RPS27A PSMC1 SEC31A KDELR1 MVD ANK1 KDELR2 INS COPB2 COPA TMED10 COPB1 GLB1 COPE CAPZB TMED3 TMED7 TMED9 COPZ2 ARFGAP3 COPZ1 ARFGAP2 VCP UBXN1 PRKCSH SEC22B NGLY1 ARF5 SEL1L DERL1 DERL2 DCTN6 GRIA1 RAB1A RNF5 DCTN5 GANAB INTEGRATION OF PROVIRUS%REACTOME%R-HSA-162592.2 Integration of provirus PSIP1 BANF1 KPNA1 HMGA1 LIG4 XRCC6 XRCC4 PPIA XRCC5 G1 S DNA DAMAGE CHECKPOINTS%REACTOME DATABASE ID RELEASE 72%69615 G1 S DNA Damage Checkpoints PSMD3 PSMD1 ZNF385A PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 CCNA2 CCNA1 UBA52 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 CDKN2A PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 UBB PSMB3 RFWD2 UBC PSMB1 PSMF1 RPS27A CHEK2 SHFM1 CHEK1 PSMB8 PSMB9 PSMC5 CDC25A PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 CCNE2 CCNE1 TP53 PCBP4 ATM CDK2 MDM2 CDKN1A MDM4 CDKN1B PHF20 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PTK6 EXPRESSION%REACTOME%R-HSA-8849473.1 PTK6 Expression NR3C1 PELP1 PTK6 EPAS1 HIF1A CD163 MEDIATING AN ANTI-INFLAMMATORY RESPONSE%REACTOME DATABASE ID RELEASE 72%9662834 CD163 mediating an anti-inflammatory response PLK2 CD163 MAPK14 IL10 IL6 MYH9 ADAM17 RHBDF2 FURIN DEGRADATION OF GLI1 BY THE PROTEASOME%REACTOME%R-HSA-5610780.1 Degradation of GLI1 by the proteasome PSMD3 CUL1 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 GLI1 PSMA1 PSMA2 PSME3 SUFU PSME4 PSME1 PSME2 UBA52 NUMB PSMD10 PSMB11 PSMD12 PRKACG PSMD11 PRKACA PSMD14 PRKACB PSMD13 PSMA7 PSMB10 PSMA8 ITCH PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 UBB PSMB3 UBC PSMB1 PSMF1 RPS27A SHFM1 PSMB8 PSMB9 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 BTRC SKP1 PSMD8 PSMD9 PSMD6 RBX1 PSMD7 PSMD4 PSMD5 PSMD2 NEUROTRANSMITTER CLEARANCE%REACTOME%R-HSA-112311.4 Neurotransmitter clearance ALDH2 MAOA BCHE SLC22A2 LRTOMT SLC22A1 COMT SLC6A3 SLC6A4 ACHE HYALURONAN METABOLISM%REACTOME%R-HSA-2142845.1 Hyaluronan metabolism STAB2 CD44 ABCC5 CEMIP LYVE1 HEXB HYAL1 HEXA HYAL2 HAS1 HYAL3 HMMR HAS3 HAS2 SLC9A1 CHP1 GUSB DEFECTIVE SLC6A3 CAUSES PARKINSONISM-DYSTONIA INFANTILE (PKDYS)%REACTOME%R-HSA-5619081.1 Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) SLC6A3 SERINE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 72%977347 Serine biosynthesis SERINC1 PSPH SERINC3 SERINC2 SERINC5 SERINC4 PSAT1 PHGDH SRR DSCAM INTERACTIONS%REACTOME DATABASE ID RELEASE 72%376172 DSCAM interactions NTN1 MAPK14 MAPK8 MAPK11 PAK1 DSCAM DSCAML1 MAPK12 MAPK13 RAC1 DCC GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION%REACTOME%R-HSA-162658.1 Golgi Cisternae Pericentriolar Stack Reorganization RAB1B GOLGA2 PLK1 USO1 GORASP1 CCNB1 CDK1 RAB2A GORASP2 BLZF1 MAPK1 RAB1A CCNB2 NEUREXINS AND NEUROLIGINS%REACTOME DATABASE ID RELEASE 72%6794361 Neurexins and neuroligins CASK LIN7A LIN7C SHARPIN LIN7B EPB41L1 STXBP1 SYT2 SYT9 APBA1 SYT7 STX1A DLG2 HOMER3 DLG4 DLG3 GRM1 GRM5 LRRTM3 EPB41 LRRTM4 LRRTM1 EPB41L5 LRRTM2 GRIN2A EPB41L2 EPB41L3 HOMER1 HOMER2 GRIN2C GRIN2B GRIN2D SHANK2 SHANK1 NLGN3 NLGN1 NLGN2 NRXN1 NRXN3 NRXN2 PDLIM5 SIPA1L1 NLGN4Y DLGAP1 DLGAP3 DLGAP2 NLGN4X DLGAP4 DBNL SYT12 SYT10 BEGAIN GRIN1 APBA3 APBA2 SYT1 C-TYPE LECTIN RECEPTORS (CLRS)%REACTOME%R-HSA-5621481.1 C-type lectin receptors (CLRs) CUL1 RAF1 CLEC4A PLCG2 CLEC4E CLEC7A CLEC6A MUC20 UBA3 MAP3K14 UBE2M PRKACG PRKACA PRKACB RELA RELB FCER1G PPP3R1 IKBKB LYN CHUK CARD9 UBE2V1 NFKB1 NFKB2 SYK CREBBP HRAS FBXW11 AHCYL1 NRAS PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PDPK1 PSMD1 PRKCD PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 IL1B PSME1 PSME2 ITPR1 ITPR2 UBA52 ITPR3 PYCARD PSMD10 PSMB11 PAK1 PSMD12 PSMD11 PSMD14 NFKBIA IKBKG FYN PSMD13 PAK3 PSMA7 PSMB10 PAK2 RPS6KA5 PSMA8 EP300 PSMB6 NFATC2 PSMB7 PSMB4 UBE2D1 PSMB5 PSMB2 UBB PSMB3 CDC34 CARD11 UBC BCL10 PSMB1 PSMF1 RPS27A SHFM1 PSMB8 UBE2D2 PSMB9 MALT1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 UBE2N MUC12 MUC13 CASP8 MUC15 MUCL1 MUC3A MUC5AC ICAM2 ICAM3 PPP3CA PPP3CB MUC1 NFATC3 NFATC1 MUC7 MUC4 MUC6 CLEC4C CLEC4D MUC17 MUC5B MUC21 CD209 BTRC SKP1 TRAF6 TAB3 TAB2 TAB1 MAP3K7 CLEC10A TNFS BIND THEIR PHYSIOLOGICAL RECEPTORS%REACTOME%R-HSA-5669034.2 TNFs bind their physiological receptors TNFRSF6B TNFSF11 TNFRSF8 TNFRSF4 EDAR TNFRSF11B TNFRSF17 TNFRSF14 TNFSF18 TNFSF14 TNFSF15 TNFRSF9 TNFSF4 FASLG TNFSF9 CD27 TNFSF8 EDA TNFRSF13B EDA2R TNFSF13B EDARADD TNFRSF18 TNFRSF1B TNFRSF1A LTA TNFRSF25 CD70 TNFSF13 DEFECTIVE C1GALT1C1 CAUSES TN POLYAGGLUTINATION SYNDROME (TNPS)%REACTOME%R-HSA-5083632.1 Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) MUC1 C1GALT1C1 MUC7 MUC12 MUC20 MUC4 MUC13 MUC6 MUC15 MUC17 C1GALT1 MUC5B MUC21 MUCL1 MUC3A MUC5AC ENOS ACTIVATION%REACTOME%R-HSA-203615.3 eNOS activation AKT1 NOS3 SPR CAV1 ZDHHC21 HSP90AA1 DDAH1 CYGB LYPLA1 DDAH2 BETA OXIDATION OF DECANOYL-COA TO OCTANOYL-COA-COA%REACTOME%R-HSA-77346.3 Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA HADH HADHB HADHA ECHS1 MECR ACADM MISSPLICED LRP5 MUTANTS HAVE ENHANCED BETA-CATENIN-DEPENDENT SIGNALING%REACTOME DATABASE ID RELEASE 72%5339717 Misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling KREMEN1 KREMEN2 LRP5 DKK1 DKK2 DKK4 DEFECTIVE SLC34A2 CAUSES PULMONARY ALVEOLAR MICROLITHIASIS (PALM)%REACTOME DATABASE ID RELEASE 72%5619045 Defective SLC34A2 causes pulmonary alveolar microlithiasis (PALM) SLC34A2 CAMK IV-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%R-HSA-111932.3 CaMK IV-mediated phosphorylation of CREB CAMK2D CREB1 CAMK2A KPNA2 CAMK4 CAMKK1 CAMKK2 CAMK2G CAMK2B PEPTIDE CHAIN ELONGATION%REACTOME%R-HSA-156902.2 Peptide chain elongation RPL26 RPL29 RPL10L RPS4X RPL10A RPL28 RPS3A RPL7A RPL23A FAU RPL41 RPS27L RPL3L UBA52 RPL37A RPS26 RPS25 RPS28 RPS27 RPL36A RPS29 RPL35A RPS20 RPS21 RPS24 RPS23 RPL22L1 RPS4Y2 RPL10 RPS4Y1 RPS27A RPL12 RPL13A RPL11 RPS3 RPL14 EEF1A1 RPL13 RPS2 RPL15 RPL18 EEF2 RPL17 RPL19 RPL27A RPL26L1 RPL4 RPL39L RPL5 RPL30 RPL3 RPL32 RPL31 RPS9 RPS7 RPL34 RPS8 RPL8 RPS5 RPL9 RPS6 RPL6 RPL7 RPSA RPL36 RPS15 RPS14 RPL35 RPS17 RPL38 RPS16 RPL37 RPL39 RPS19 RPS15A RPL18A RPL36AL RPS18 RPLP1 RPL21 RPL23 RPS11 RPL22 RPLP0 RPS10 RPS13 RPS12 RPLP2 RPL24 RPL27 THE RETINOID CYCLE IN CONES (DAYLIGHT VISION)%REACTOME DATABASE ID RELEASE 72%2187335 The retinoid cycle in cones (daylight vision) OPN1LW AWAT2 OPN1MW OPN1MW2 RBP3 RLBP1 OPN1SW DHRS3 DISEASES ASSOCIATED WITH N-GLYCOSYLATION OF PROTEINS%REACTOME%R-HSA-3781860.1 Diseases associated with N-glycosylation of proteins DPAGT1 ALG8 ALG9 ALG6 ALG14 ALG3 ALG2 ALG13 B4GALT1 ALG12 MOGS ALG1 ALG11 MPDU1 MAN1B1 RFT1 MGAT2 GAMMA-CARBOXYLATION, TRANSPORT, AND AMINO-TERMINAL CLEAVAGE OF PROTEINS%REACTOME DATABASE ID RELEASE 72%159854 Gamma-carboxylation, transport, and amino-terminal cleavage of proteins F7 GAS6 PROC F9 F10 PROS1 PROZ BGLAP FURIN F2 GGCX DIGESTION%REACTOME DATABASE ID RELEASE 72%8935690 Digestion CHIA AMY2A CHIT1 PNLIP AMY1A AMY2B AMY1B TREH AMY1C GUCA2B GUCA2A PIR GUCY2C MGAM LIPF SI PNLIPRP1 LCT ALPI PNLIPRP3 CLPS ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS%REACTOME%R-HSA-450341.1 Activation of the AP-1 family of transcription factors MAPK9 MAPK14 MAPK8 MAPK11 MAPK10 ATF2 FOS JUN MAPK1 MAPK3 SYNTHESIS OF EPOXY (EET) AND DIHYDROXYEICOSATRIENOIC ACIDS (DHET)%REACTOME DATABASE ID RELEASE 72%2142670 Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) EPHX2 CYP2C19 CYP1B1 CYP2J2 CYP2C9 CYP1A2 CYP1A1 CYP2C8 MECP2 REGULATES TRANSCRIPTION FACTORS%REACTOME%R-HSA-9022707.1 MECP2 regulates transcription factors CREB1 MEF2C PPARG RBFOX1 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION%REACTOME DATABASE ID RELEASE 72%2173796 SMAD2 SMAD3:SMAD4 heterotrimer regulates transcription RNF111 MEN1 SNW1 CCNC SMAD2 SMAD3 UBA52 TFDP1 RBL1 SMAD7 TFDP2 WWTR1 E2F5 CDK9 JUNB SMAD4 E2F4 UBB CCNK UBC CCNT2 SERPINE1 CCNT1 RPS27A TGIF1 TGIF2 HDAC1 SP1 ATP1B4 MYC CDKN2B CDK8 PHASE II - CONJUGATION OF COMPOUNDS%REACTOME%R-HSA-156580.2 Phase II - Conjugation of compounds N6AMT1 TPMT GSTK1 SLC26A2 SLC26A1 UGP2 CYP1A2 SULT1A1 AS3MT SULT1A4 SULT1A3 AHCY SULT1A2 GSTM4 GSTM3 UGT1A1 GSTM2 GSTM1 SULT1B1 GSTM5 UGT1A5 UGT1A4 SULT1C2 UGT1A3 UGT1A9 UGT1A8 UGT1A7 UGT1A6 SULT1C4 GSTO2 BPNT1 ABHD10 GSTO1 SULT6B1 NNMT SLC35B3 SLC35B2 GLYAT MTRR AKR1A1 GLYATL3 GLYATL2 GLYATL1 NAT1 NAT2 PODXL2 GSTP1 ESD UGT3A2 UGT3A1 TRMT112 SULT1E1 GGT1 SLC35D1 MAT1A UGT2B10 UGT2B11 UGT2B15 UGT2B17 TPST2 TPST1 GGT5 GSTT2 GGT7 GSTT1 GGT6 GCLC UGT1A10 GCLM ACSM5 ACSM2A ACSM4 MTR UGDH HPGDS CHAC2 CHAC1 SULT4A1 ABHD14B MGST3 GGCT MGST1 UGT2A3 MGST2 UGT2A2 UGT2A1 MAT2B MAT2A IMPAD1 UGT2B4 GSTA5 ACSM1 GSTA4 ACSM2B GSTA3 GSTA2 GSTA1 GSTT2B UGT2B7 COMT CNDP2 UGT2B28 GSTZ1 PAPSS2 PAPSS1 SULT2A1 GSS OPLAH DOWNREGULATION OF ERBB2 SIGNALING%REACTOME%R-HSA-8863795.2 Downregulation of ERBB2 signaling AKT1 NRG1 PTPN12 NRG2 NRG3 NRG4 EGF EGFR UBA52 RNF41 ERBB2IP HSP90AA1 CDC37 ERBB2 BTC PTPN18 UBB MATK HBEGF EREG UBC STUB1 RPS27A CUL5 AKT2 AKT3 USP8 DEFECTIVE SLC3A1 CAUSES CYSTINURIA (CSNU)%REACTOME%R-HSA-5619113.1 Defective SLC3A1 causes cystinuria (CSNU) SLC7A9 SLC3A1 INFLUENZA INFECTION%REACTOME%R-HSA-168255.4 Influenza Infection RPL26 GRSF1 RPL29 RPL10L RPS4X RPL10A RPL28 RPS3A POLR2E POLR2F RPL23A POLR2H FAU NUP107 NUP188 CANX POLR2K RPL41 POLR2L CPSF4 CALR KPNA1 RPL3L NUP62 PABPN1 NDC1 NUP214 SEC13 NUP133 NUP210 NUP93 NUP50 NUP54 RPL10 RPL12 RPL13A RPL11 RPS3 POM121 RPL14 NUP205 RPL13 RPS2 AAAS RPL15 NUP160 RPL18 GTF2F1 RPL17 GTF2F2 RPL19 NUP85 POLR2A TPR POLR2B RPL27A POLR2C NUP88 POLR2D NUP43 POLR2G RAE1 POLR2I POLR2J RANBP2 NUP155 NUP153 NUP35 NUPL2 RPS9 RPS7 RPS8 NUP37 RPS5 RPS6 RPSA RPS15 RPS14 RPS17 RPS16 RPS19 RPL18A RPL36AL CLTC RPS18 RPLP1 CLTA RPS11 RPS10 RPLP0 RPS13 RPS12 XPO1 RPLP2 RPL7A RPS27L UBA52 RPL37A RPS26 RPS25 RPS28 RPS27 RPL36A RPS29 RPS20 RPL35A RPS21 RPS24 RPS23 RPL22L1 KPNA7 KPNA4 KPNA5 KPNA2 KPNA3 RPS4Y2 RPS4Y1 RPS27A KPNB1 EIF2AK2 ISG15 RAN RPL26L1 RPL4 RPL39L RPL5 HSP90AA1 RPL30 RPL3 RPL32 RPL31 RPL34 RPL8 RPL9 SLC25A6 RPL6 RPL7 TGFB1 RPL36 RPL35 RPL38 RPL37 RPL39 RPS15A RPL21 RPL23 RPL22 DNAJC3 IPO5 RPL24 RPL27 UNC93B1 DEFICIENCY - HSE%REACTOME%R-HSA-5602415.1 UNC93B1 deficiency - HSE UNC93B1 TLR3 BETA-CATENIN INDEPENDENT WNT SIGNALING%REACTOME%R-HSA-3858494.3 Beta-catenin independent WNT signaling CAMK2A PRKCG WNT5B DAAM1 PFN1 WNT11 PRKG2 PLCB3 PLCB1 NLK PLCB2 PRKG1 TNRC6C PPP3R1 PDE6G TNRC6A TNRC6B PDE6B PDE6A TCF7L2 FZD4 FZD6 FZD8 MOV10 AGO3 AGO4 AGO1 AGO2 FZD2 FZD5 WNT5A CLTC CLTB CLTA AP2A1 AP2B1 AP2A2 AP2S1 ROR1 PSMD8 ROR2 PSMD9 AP2M1 PSMD6 PSMD7 PSMD4 RAC1 PSMD5 PSMD2 PRKCB PSMD3 PSMD1 PRKCA RAC2 PSMA5 RAC3 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 ARRB2 PSME4 PSME1 PSME2 ITPR1 ITPR2 UBA52 ITPR3 PSMD10 DVL1 PSMB11 PSMD12 DVL3 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 SCRIB PSMA8 PRICKLE1 GNAT2 DVL2 FZD1 PSMB6 FZD3 SMURF2 PSMB7 FZD7 VANGL2 PSMB4 PSMB5 PSMB2 UBB PSMB3 CTNNB1 UBC PSMB1 PSMF1 RPS27A SHFM1 GNG10 PSMB8 PSMB9 PSMC5 PSMC6 PSMC3 GNG12 PSMC4 GNG11 PSMC1 GNG13 PSMC2 GNAO1 GNB2 GNB1 TCF7 GNB4 WNT1 GNB3 WNT4 GNB5 GNGT1 GNGT2 LEF1 TCF7L1 SMURF1 PPP3CA PPP3CB NFATC1 GNG3 RHOA GNG2 GNG5 GNG4 PARD6A GNG7 GNG8 MAP3K7 TRANSLOCATION OF ZAP-70 TO IMMUNOLOGICAL SYNAPSE%REACTOME DATABASE ID RELEASE 72%202430 Translocation of ZAP-70 to Immunological synapse CD4 HLA-DQA2 HLA-DQA1 HLA-DRB5 HLA-DPA1 HLA-DRB4 HLA-DPB1 CD3G HLA-DRA HLA-DRB3 TRAV19 HLA-DRB1 PTPN22 CD3E CD3D ZAP70 HLA-DQB2 HLA-DQB1 LCK OLEOYL-PHE METABOLISM%REACTOME%R-HSA-9673163.1 Oleoyl-phe metabolism PM20D1 GENE AND PROTEIN EXPRESSION BY JAK-STAT SIGNALING AFTER INTERLEUKIN-12 STIMULATION%REACTOME%R-HSA-8950505.3 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation LMNB1 CFL1 CAPZA1 HSPA9 SOD1 PPIA ANXA2 PSME2 SOD2 GSTA2 IL10 CDC42 GSTO1 TCP1 SERPINB2 BOLA2 SNRPA1 PAK2 MIF LCP1 RALA RAP1B AIP BOLA2B HNRNPDL STAT4 CNN2 MSN MTAP IFNG HNRNPF HNRNPA2B1 PDCD4 ARF1 PITPNA RPLP0 CA1 TALDO1 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 72%1660499 Synthesis of PIPs at the plasma membrane SBF2 OCRL PIK3R2 RAB5A MTM1 RAB4A PI4K2B PTPN13 SYNJ2 SYNJ1 PIK3C2G PIK3C2A PIK3R3 PIP5K1A PIK3C2B PIP5K1B PIP5K1C PIK3R6 PIK3R5 PI4K2A BMX RUFY1 PIP4K2A PIP4K2B PIP4K2C INPP4A MTMR14 INPP4B MTMR1 MTMR2 INPPL1 MTMR3 PIK3CD MTMR8 PIK3CG MTMR9 INPP5D INPP5J PIK3R1 INPP5K MTMR6 PIK3CA RAB14 ARF1 PLEKHA1 PIK3CB PLEKHA5 PLEKHA6 PLEKHA3 PTEN PLEKHA4 PLEKHA8 MYD88-INDEPENDENT TLR4 CASCADE%REACTOME DATABASE ID RELEASE 72%166166 MyD88-independent TLR4 cascade CUL1 MAP2K1 MAPKAPK3 PTPN11 UBA52 MAPK8 PPP2R1B ATF1 PPP2R1A APP ATF2 NFKBIA IKBKG IKBKE ELK1 RELA RPS6KA3 RPS6KA5 RPS6KA2 RPS6KA1 DUSP4 PPP2R5D MEF2A MEF2C UBE2D1 DUSP3 BIRC2 FOS BIRC3 VRK3 UBB DUSP6 DUSP7 UBC CREB1 MAPKAPK2 RPS27A IRF3 UBE2D2 TRAF3 MAPK7 UBE2D3 MAPK1 MAPK3 PPP2CA HMGB1 PPP2CB IKBKB NKIRAS1 NKIRAS2 MAPK14 MAP3K8 MAP2K3 CHUK MAPK11 MAP2K4 RIPK2 UBE2N UBE2V1 CASP8 NOD1 NFKB1 NOD2 NFKB2 AGER MAPK9 IRAK1 RIPK1 MAP2K6 S100A12 MAP2K7 FADD S100B MAPK10 TNIP2 JUN SAA1 NFKBIB FBXW11 TBK1 RIPK3 IRF7 TANK BTRC SKP1 IRAK2 TRAF6 TICAM2 TAB3 LY96 TAB2 TICAM1 TAB1 MAP3K7 CD14 TLR4 EICOSANOIDS%REACTOME DATABASE ID RELEASE 72%211979 Eicosanoids PTGIS CYP4A11 CYP4F22 CYP4F2 CYP4F3 CYP4F8 CYP4B1 CYP4A22 TBXAS1 CYP4F11 CYP8B1 CYP4F12 ACYL CHAIN REMODELING OF DAG AND TAG%REACTOME DATABASE ID RELEASE 72%1482883 Acyl chain remodeling of DAG and TAG DGAT1 AWAT2 PNPLA3 DGAT2L6 MGLL DGAT2 PNPLA2 ALPK1 SIGNALING PATHWAY%REACTOME%R-HSA-9645460.2 ALPK1 signaling pathway UBC TIFA RPS27A ALPK1 UBA52 TRAF6 TAB3 TAB2 TAB1 UBB MAP3K7 ACTIVATION OF BMF AND TRANSLOCATION TO MITOCHONDRIA%REACTOME DATABASE ID RELEASE 72%139910 Activation of BMF and translocation to mitochondria BMF MAPK8 DYNLL2 PTK6 REGULATES RTKS AND THEIR EFFECTORS AKT1 AND DOK1%REACTOME DATABASE ID RELEASE 72%8849469 PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 UBC AKT1 CBL PTK6 RPS27A UBA52 ARAP1 DOK1 UBB TOXICITY OF BOTULINUM TOXIN TYPE D (BONT D)%REACTOME DATABASE ID RELEASE 72%5250955 Toxicity of botulinum toxin type D (BoNT D) VAMP1 SV2B SV2A SV2C VAMP2 FORMATION OF THE CORNIFIED ENVELOPE%REACTOME%R-HSA-6809371.3 Formation of the cornified envelope LCE1E LCE1F LOR LCE1C LCE1D LCE2B LCE2C LCE2A LCE6A PKP2 PKP4 SPINK9 PKP3 DSG4 IVL DSC2 DSC3 FLG SPRR2E SPRR2F PERP SPRR3 SPRR2G CSTA KLK5 KLK8 EVPL LCE2D LCE3C DSP LCE3D LCE3A LCE3B LELP1 DSG1 SPRR2A PKP1 SPRR2B SPRR2D JUP DSG2 ST14 CDSN DSG3 KLK13 KLK14 LCE3E KLK12 LCE4A SPRR1A SPRR1B CAPNS1 CAPN1 PI3 PPL TCHH LCE1A TGM1 CASP14 LCE1B LCE5A DSC1 LIPJ LIPN LIPM LIPK PRSS8 TGM5 RPTN CELA2A FURIN PCSK6 SPINK6 SPINK5 KAZN LIGAND-INDEPENDENT CASPASE ACTIVATION VIA DCC%REACTOME DATABASE ID RELEASE 72%418889 Ligand-independent caspase activation via DCC UNC5B DAPK2 DAPK3 CASP3 APPL1 CASP9 MAGED1 UNC5A DCC DAPK1 RHESUS BLOOD GROUP BIOSYNTHESIS%REACTOME%R-HSA-9037628.1 Rhesus blood group biosynthesis RHCE RHD CONJUGATION OF BENZOATE WITH GLYCINE%REACTOME%R-HSA-177135.1 Conjugation of benzoate with glycine GLYAT ACSM1 ACSM2B GLYATL3 GLYATL2 GLYATL1 B CELL ACTIVATION%REACTOME%R-HSA-983705.1 B Cell Activation CUL1 PLCG2 DAPP1 RASGRP1 RASGRP3 RELA IGKV1-12 NFKBIE BLNK IGKV2D-28 IGKV4-1 IGKV2D-30 PPP3R1 IGKV3-11 IKBKB LYN CHUK STIM1 ORAI2 ORAI1 PPIA NFKB1 IGKV2-28 SYK IGKV3D-20 NFKBIB HRAS FBXW11 AHCYL1 NRAS CD19 PSMD8 PSMD9 TRPC1 IGKV5-2 PSMD6 SH3KBP1 PSMD7 PSMD4 PSMD5 NCK1 PSMD2 PRKCB PSMD3 PSMD1 VAV1 PIK3AP1 PSMA5 PSMA6 BLK PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PTPN6 PSME1 PSME2 ITPR1 ITPR2 UBA52 ITPR3 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 NFKBIA IKBKG FYN PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 NFATC2 PSMB7 PSMB4 PSMB5 PSMB2 UBB PSMB3 CARD11 UBC BCL10 PSMB1 PSMF1 RPS27A SHFM1 PSMB8 PSMB9 MALT1 PSMC5 PSMC6 PSMC3 REL PSMC4 PSMC1 PSMC2 PIK3CD PIK3R1 SOS1 PPP3CA PPP3CB NFATC3 CD79B NFATC1 CD79A FKBP1A BTRC SKP1 CD22 BTK MAP3K7 SIGNALING BY FGFR2 AMPLIFICATION MUTANTS%REACTOME DATABASE ID RELEASE 72%2023837 Signaling by FGFR2 amplification mutants FGFR2 DEFECTIVE SLC40A1 CAUSES HEMOCHROMATOSIS 4 (HFE4) (DUODENUM)%REACTOME%R-HSA-5655799.1 Defective SLC40A1 causes hemochromatosis 4 (HFE4) (duodenum) SLC40A1 HEPH TRANSPORT OF FATTY ACIDS%REACTOME DATABASE ID RELEASE 72%804914 Transport of fatty acids LCN9 SLC27A1 LCN1 LCN15 SLC27A6 LCN12 APOD SLC27A4 AXIN MUTANTS DESTABILIZE THE DESTRUCTION COMPLEX, ACTIVATING WNT SIGNALING%REACTOME%R-HSA-4839735.1 AXIN mutants destabilize the destruction complex, activating WNT signaling CSNK1A1 PPP2CA PPP2CB PPP2R5B PPP2R5A PPP2R5D GSK3B PPP2R5C PPP2R1B PPP2R1A AMER1 AXIN1 APC PPP2R5E INTRINSIC PATHWAY OF FIBRIN CLOT FORMATION%REACTOME%R-HSA-140837.7 Intrinsic Pathway of Fibrin Clot Formation SERPIND1 VWF F10 GP1BB F12 F11 GP1BA F2 GP5 GP9 F8 PROC SERPINE2 F9 SERPINC1 SERPING1 PROS1 PRCP KLKB1 KNG1 SERPINA5 C1QBP A2M LEWIS BLOOD GROUP BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 72%9037629 Lewis blood group biosynthesis ST3GAL4 B3GALT4 ST3GAL6 B3GALT5 FUT10 ST3GAL3 FUT11 FUT2 B4GALNT2 FUT4 FUT3 FUT6 FUT5 FUT7 FUT9 B3GALT2 B3GALT1 ST6GALNAC6 G BETA:GAMMA SIGNALLING THROUGH CDC42%REACTOME DATABASE ID RELEASE 72%8964616 G beta:gamma signalling through CDC42 GNG11 GNG13 GNB2 GNB1 GNB4 GNB3 GNG3 GNG2 GNG5 GNB5 GNG4 GNG7 GNG8 GNGT1 GNGT2 CDC42 PAK1 ARHGEF6 GNG10 GNG12 MPS IV - MORQUIO SYNDROME B%REACTOME%R-HSA-2206308.2 MPS IV - Morquio syndrome B GLB1 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX%REACTOME%R-HSA-68827.2 CDT1 association with the CDC6:ORC:origin complex PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 UBA52 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 UBB PSMB3 UBC PSMB1 PSMF1 RPS27A SHFM1 GMNN PSMB8 PSMB9 PSMC5 PSMC6 PSMC3 ORC5 PSMC4 ORC4 PSMC1 ORC6 PSMC2 ORC1 ORC3 ORC2 CDT1 CDC6 MCM8 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 TRANSPORT OF GAMMA-CARBOXYLATED PROTEIN PRECURSORS FROM THE ENDOPLASMIC RETICULUM TO THE GOLGI APPARATUS%REACTOME%R-HSA-159763.3 Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus F7 GAS6 PROC F9 F10 PROS1 PROZ BGLAP F2 DEFECTIVE ALG6 CAUSES ALG6-CDG (CDG-1C)%REACTOME DATABASE ID RELEASE 72%4724289 Defective ALG6 causes ALG6-CDG (CDG-1c) ALG6 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS%REACTOME DATABASE ID RELEASE 72%77588 SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs ZNF473 SNRPG SNRPE SLBP SNRPF SNRPB LSM10 LSM11 NCBP1 NCBP2 SNRPD3 MGMT-MEDIATED DNA DAMAGE REVERSAL%REACTOME DATABASE ID RELEASE 72%5657655 MGMT-mediated DNA damage reversal MGMT BUTYRATE RESPONSE FACTOR 1 (BRF1) BINDS AND DESTABILIZES MRNA%REACTOME DATABASE ID RELEASE 72%450385 Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA AKT1 ZFP36L1 DCP1A EXOSC7 DIS3 EXOSC6 EXOSC5 EXOSC4 XRN1 EXOSC9 EXOSC8 EXOSC3 YWHAB MAPKAPK2 EXOSC2 DCP2 EXOSC1 O-LINKED GLYCOSYLATION%REACTOME%R-HSA-5173105.4 O-linked glycosylation GALNT2 GALNT1 MUC20 B4GAT1 B4GALT6 B4GALT5 ST6GALNAC2 ST6GAL1 ST6GALNAC3 ST6GALNAC4 POMT2 GALNT12 SEMA5A SEMA5B SPON2 SPON1 THSD7B ST3GAL4 POMT1 ADAMTSL1 ADAMTS4 ST3GAL1 ADAMTS5 ADAMTS2 C1GALT1C1 ST3GAL2 ADAMTS3 ST3GAL3 ADAMTSL4 ADAMTS1 ADAMTSL3 ADAMTSL2 GALNT11 MUC12 GALNT14 DAG1 GALNT13 MUC13 GALNT16 MUC15 GALNT15 THSD7A GALNT18 ADAMTS8 GALNT10 ADAMTS9 POFUT2 ADAMTS6 WBSCR17 ADAMTS7 GYLTL1B SBSPON MUCL1 B3GALNT2 MUC3A GALNTL5 GALNTL6 POMGNT1 B3GNTL1 MUC5AC GALNT9 ADAMTS20 B3GLCT GALNT8 CFP POMGNT2 ADAMTS12 B3GNT9 B3GNT8 THBS2 B3GNT6 THSD1 B3GNT5 THBS1 CHST4 THSD4 ADAMTS10 GCNT1 ADAMTS16 GCNT3 ADAMTS15 GCNT4 ADAMTS14 GCNT7 MUC1 GALNT7 ADAMTS13 GALNT6 ADAMTS19 GALNT5 ADAMTS18 GALNT4 LARGE A4GNT ADAMTS17 POMK MUC7 MUC4 MUC6 GALNT3 MUC17 C1GALT1 MUC5B MUC21 B3GNT7 B3GNT4 B3GNT3 B3GNT2 MITOCHONDRIAL TRANSLATION TERMINATION%REACTOME%R-HSA-5419276.1 Mitochondrial translation termination MRPL39 MRPL36 MRPL37 MRPL34 MRPL35 MRPL32 MRPL33 MRPL4 MRPL41 MRPL3 MRPL42 MRPL2 MRPL1 MRPL40 MRPL9 CHCHD1 MRPS28 MRPS26 MRPS27 MRPS24 MRPS25 MRPS22 MRPS23 MRPL49 MRPS18B MRPS2 MRPS18A MRPL47 MRPL48 MRPL45 MRPS7 MRPL46 MRPS6 MRPS5 MRPL43 MRPS18C MRPL44 MRPL52 OXA1L MRPL53 MRPL50 MRPS9 MRPL51 AURKAIP1 DAP3 MRPS35 MRPS36 MRPL18 MRPS33 MRPL19 MRPS34 MRPL16 MRPS31 MRPL17 MRPL14 MRPL15 MRPS30 MRPL12 MRPL57 MRPL13 MRPL10 MRPL54 MRPL55 MRPL11 MRPL20 ICT1 GADD45GIP1 PTCD3 MRPL27 MRPL28 ERAL1 MRPL23 MRPL24 MRPL21 MRPL22 MRPL30 GFM2 MRRF MRPS17 MRPS15 MRPS16 MTRF1L MRPS14 MRPS11 MRPS12 MRPL38 MRPS10 SEMA4D IN SEMAPHORIN SIGNALING%REACTOME DATABASE ID RELEASE 72%400685 Sema4D in semaphorin signaling SEMA4D ARHGAP35 RND1 MYL12B MYH9 MET LIMK2 LIMK1 RHOA MYH11 ROCK1 ROCK2 RHOC RRAS RHOB MYH14 MYH10 ARHGEF11 PLXNB1 ARHGEF12 MYL6 ERBB2 MYL9 RAC1 FRUCTOSE CATABOLISM%REACTOME%R-HSA-70350.6 Fructose catabolism ALDOB KHK GLYCTK TKFC ALDH1A1 NUCLEOTIDE METABOLISM%REACTOME DATABASE ID RELEASE 72%15869 Nucleotide metabolism HPRT1 CAD NUDT16 DCK NUDT15 NT5C2 NUDT13 DHODH GPX1 ADSSL1 NT5C1A NT5C1B RRM1 RRM2 DCTD ENTPD1 ENTPD2 RRM2B CMPK1 ENTPD3 ENTPD4 ENTPD5 ENTPD6 GLRX ENTPD7 GMPS ADA ADK ENTPD8 GMPR TAF9 CDA PFAS IMPDH1 IMPDH2 APRT ADSL ADPRM DNPH1 DTYMK TXNRD1 AGXT2 UPB1 HDHD1 UCKL1 TYMS XDH TYMP NT5C DPYS NT5E PAICS NT5M GDA CTPS2 CTPS1 LHPP DGUOK SAMHD1 ATIC AK6 ADSS TXN UPP2 GMPR2 UPP1 ITPA DCTPP1 TK2 TK1 DPYD GART GUK1 AK1 PNP AK2 UCK2 UCK1 NUDT5 AK4 AK5 AK7 PPAT NME2 AK8 NME3 AK9 AMPD1 NME4 ADAL AMPD2 AMPD3 NME1 UMPS MACROAUTOPHAGY%REACTOME%R-HSA-1632852.8 Macroautophagy DYNC1LI1 DYNC1LI2 PRKAA1 PRKAA2 CSNK2A1 CSNK2A2 PIK3R4 PARK7 CSNK2B DYNLL2 MTMR14 PRKAB2 PRKAB1 RRAGA DYNC1I1 RRAGC MTMR3 RRAGB RRAGD CHMP2A UBE2V1 HSF1 TOMM20 TOMM22 ATG3 GABARAPL2 GABARAPL1 ATG9B ATG9A ATG10 ATG14 ATG13 ULK1 GABARAP ATG101 UVRAG ATM MTERF3 ATG16L1 CETN1 DYNLL1 WDR45 MAP1LC3B MAP1LC3A MAP1LC3C FUNDC1 RB1CC1 USP30 WIPI2 PRKAG1 PEX5 MLST8 ATG4C PRKAG2 ATG4B ATG4A DYNC1I2 ATG4D PRKAG3 BECN1 TOMM40 WDR45B RPTOR AMBRA1 MFN1 MFN2 TOMM70A NBR1 PCNT TOMM7 TOMM5 TOMM6 DYNC1H1 CHMP2B CHMP4C CHMP4B UBA52 CHMP3 CHMP4A CHMP6 CHMP7 ATG7 MTOR LAMTOR2 UBB LAMTOR1 LAMTOR4 LAMTOR3 UBC LAMTOR5 RPS27A HSPA8 VDAC1 TSC2 TSC1 UBE2N EPAS1 SLC38A9 HSP90AA1 ATG12 PIK3C3 ATG5 PLIN3 PARK2 PLIN2 HDAC6 RHEB WIPI1 CFTR VCP IFT88 SQSTM1 ARL13B PINK1 MITOCHONDRIAL PROTEIN IMPORT%REACTOME DATABASE ID RELEASE 72%1268020 Mitochondrial protein import ATP5G1 TOMM70A TOMM7 TOMM5 TOMM6 SAMM50 CHCHD4 HSPA9 CHCHD5 CHCHD2 MTX1 CHCHD7 MTX2 TIMM17A TIMM17B COA6 CMC4 CMC2 PAM16 TIMM23 TIMM22 TIMM21 BCS1L CYC1 COX19 TIMM9 COX17 TIMM13 TIMM10 TIMM50 GRPEL1 PITRM1 GRPEL2 LDHD TIMM8B COA4 DNAJC19 TIMM8A CHCHD10 TIMM44 GFER TIMM10B ATP5B SLC25A12 SLC25A13 ACO2 VDAC1 OTC HSCB IDH3G FXN TAZ TOMM20 HSPD1 TOMM22 SLC25A4 SLC25A6 NDUFB8 CS PMPCB PMPCA COQ2 ATP5A1 CHCHD3 TOMM40 MITOTIC METAPHASE ANAPHASE TRANSITION%REACTOME%R-HSA-68881.2 Mitotic Metaphase Anaphase Transition PLK1 FBXO5 HDR THROUGH HOMOLOGOUS RECOMBINATION (HRR) OR SINGLE STRAND ANNEALING (SSA)%REACTOME DATABASE ID RELEASE 72%5693567 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) EXO1 WHSC1 POLK RPA1 POLE RPA2 POLH POLD3 TOPBP1 RFC1 POLD4 WRN RPA3 POLD1 POLD2 DNA2 RFC5 SPIDR RFC3 RFC4 RFC2 RNF8 RNF4 CCNA2 CCNA1 RAD52 POLE4 RAD51 RBBP8 BRE ERCC4 ERCC1 POLE2 HIST3H3 POLE3 MDC1 KAT5 RAD50 CHEK1 HUS1 RHNO1 BRIP1 ATRIP BARD1 RAD17 ATM UBE2I ATR BRCA1 SUMO1 SUMO2 HERC2 PPP4R2 RTEL1 TIPIN RMI2 RMI1 TOP3A RAD51D PIAS4 UBA52 BRCC3 PPP4C TP53BP1 HIST3H2BB XRCC2 XRCC3 MRE11A HIST1H2BF HIST1H2BE HIST1H2BH HIST1H2BG HIST1H2BB HIST1H2BA HIST1H2BD HIST1H2BC BRCA2 UBB RAD1 BABAM1 UIMC1 UBC SIRT6 RPS27A RAD51B RNF168 RAD51C NBN HIST1H4K HIST1H4L SLX4 H2BFS HIST1H4A HIST1H4B HIST1H4H HIST1H4I HIST1H4J HIST1H4C HIST1H4D HIST1H4E UBE2N HIST1H4F EME1 EME2 GEN1 SLX1B TIMELESS UBE2V2 SLX1A H2AFX RAD51AP1 ABL1 HIST2H2BE CLSPN HIST4H4 CDK2 PALB2 HIST1H2BN HIST1H2BM RAD9B HIST1H2BO RAD9A HIST1H2BJ FAM175A HIST1H2BI HIST1H2BL HIST1H2BK MUS81 HIST2H4A BLM HIST2H4B PCNA DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY%REACTOME%R-HSA-2173795.1 Downregulation of SMAD2 3:SMAD4 transcriptional activity PPM1A NCOR1 SMAD4 RNF111 SMURF2 UBE2D1 UBB PARP1 NEDD4L UBC SMAD2 SKIL TGIF1 SMAD3 RPS27A UBA52 TGIF2 USP9X HDAC1 SKI TRIM33 UBE2D3 NCOR2 SCN4%REACTOME%R-HSA-3282872.2 SCN4 G6PC3 PHASE 4 - RESTING MEMBRANE POTENTIAL%REACTOME%R-HSA-5576886.1 Phase 4 - resting membrane potential KCNK17 KCNK18 KCNK5 KCNJ2 KCNJ4 KCNK6 KCNK7 KCNJ12 KCNK9 KCNJ14 KCNK10 KCNK1 KCNK12 KCNK2 KCNK13 KCNK3 KCNK4 KCNK15 KCNK16 POST-TRANSLATIONAL PROTEIN MODIFICATION%REACTOME%R-HSA-597592.7 Post-translational protein modification BTBD1 CUL1 RAB1B UBE2F DCTN4 UBE2H KLHL25 ZBTB16 GALNT2 GALNT1 MEN1 ARCN1 KLHL21 KLHL22 CAPZA3 UBE2A BTBD6 FBXO30 CAPZA1 KLHL20 CAPZA2 FBXO31 RAB18 UBE2W COPG2 UBE2S COPG1 ACTR10 UBA1 UBE2K KBTBD13 UBE2Q2 DDX5 ZNF131 ZNF350 UHRF2 UBE2R2 CTBP1 PARK7 BMI1 RNF2 TRIM28 ASB13 ASB14 NRIP1 ASB11 CBX8 DDX17 RNF7 PHC2 ASB12 PHC1 RING1 ASB17 ASB18 CBX4 FBXL22 CBX2 ASB15 PCGF2 MBD1 ASB16 MKL1 FBXL20 SAFB PHC3 SLC35A1 ASB10 SLC35C1 FBXL19 FBXL15 FBXL16 FBXL13 FBXL14 FBXL12 ASB8 ASB9 ASB6 ASB7 ASB4 ASB5 ASB2 ASB1 PPARGC1A GPIHBP1 DPAGT1 MPI ALG8 ALG9 ALG6 CUL3 ALG14 ALG3 ALG13 ALG12 ALG1 ALG11 DHDDS ARF3 MPDU1 KBTBD7 ARF1 NUS1 PMM2 DOLK RFT1 MGAT2 C3 FURIN SUMF2 SUMF1 AR RORA WDR61 MYC LEO1 SKP2 CDC25A SRD5A3 TNC IGFBP7 TRAPPC4 USP34 CDC73 AXIN2 BPIFB2 OTUD5 ST6GALNAC6 SEC23A TGFB1 SMAD4 TRRAP TGFBR1 RHOA TGFBR2 HCFC1 CTR9 RTF1 NR3C2 BLM PAF1 PCNA SEC24B RPA1 TADA2B SEC24A WRN HIST2H2AB SEC24D SEC24C UBA3 ARSA PRMT3 SOCS6 UBE2M HIST2H2BF FGF23 RELA HIST3H2A KDM1B TFAP2B MITF FOXL2 ARSJ HIC1 HIST1H2AG SP3 ARSK HIST1H2AA ARSH ARSI HIST1H2AM ARSF HIST1H2AL ARSG ARSD HIST1H2AI HIST1H2AH ARSE HIST1H2AK ARSB CTSA ATXN7 RAB27A ESR1 KCTD6 NFKB2 TADA3 OGT NCOA1 NCOA2 WDR5 TMED2 RAB6A RXRA GPC3 RBBP5 USP22 PGR GATA3 SP100 AXIN1 L3MBTL2 CBX5 FUT3 VDR MVD MAT2B INS MBTPS1 GLB1 RIPK1 TRAF2 DCAF13 NOP58 USP4 VCP UBXN1 PRKCSH NGLY1 SEL1L DERL1 DERL2 RNF5 GANAB RNF139 OS9 MLEC UGGT2 UGGT1 PDIA3 EDEM3 EDEM1 AMFR EDEM2 SYVN1 MOGS MARCH6 RAD23B CYLD RNF103 OTUD7B CANX TRIM13 TNFAIP3 CALR MAN1B1 RNF185 ENGASE FOXO4 BIRC2 BIRC3 USP21 OTULIN ADRB2 RPS2 GOLGA2 IL6 SMAD7 UCHL1 SENP8 UCHL3 UCHL5 TOMM20 USP15 FOXK2 FOXK1 MBD5 MBD6 ADRM1 ASXL1 ASXL2 HSP90B1 USP30 SENP5 SENP2 SENP1 BECN1 ALB TOMM70A EIF5A2 PROZ BGLAP EIF5A FN3K ICMT DHPS FN3KRP DOHH GGCX GAS6 NLRP3 FSTL3 NOTUM FOLR2 POMT2 GALNT12 SEMA5A SEMA5B SPON2 SPON1 THSD7B VDAC1 POMT1 ADAMTSL1 ADAMTS4 FUCA1 ADAMTS5 FUCA2 ADAMTS2 C1GALT1C1 ADAMTS3 THRB ADAMTSL4 NR2C1 ADAMTS1 NR4A2 NR5A1 ADAMTSL3 ADAMTSL2 MUC12 SERPINA1 DAG1 MUC13 MUC15 THSD7A ADAMTS8 ADAMTS9 AHSG ADAMTS6 ADAMTS7 SBSPON MUCL1 MUC3A POMGNT1 MUC5AC ADAMTS20 CUL7 B3GLCT DCTN1 TFG CFP ADAMTS12 GOSR2 LMAN1L LMAN2L THBS2 THSD1 UMOD SCFD1 THBS1 CHST10 THSD4 ADAMTS10 MIA2 ADAMTS16 MIA3 RAB3D ADAMTS15 ASGR1 ADAMTS14 ASGR2 CHST8 MUC1 ADAMTS13 STX17 RAB44 ADAMTS19 USO1 ADAMTS18 LMAN1 LMAN2 LARGE ADAMTS17 MGAT5 MGAT3 MUC7 MGAT1 WFS1 MUC4 TRAPPC10 MUC6 GFPT1 SEC23IP GALNT3 MUC17 TUSC3 RAB31 C1GALT1 MANEA PDIA6 MUC5B RAB37 TRAPPC2L ARFGAP1 TBC1D20 MUC21 FUT8 TRAPPC2 DNAJC3 ANKRD28 TRAPPC3 SEC16B RAB5B SEC16A PREB TRAPPC5 B3GNT7 TRAPPC9 B3GNT4 TRAPPC1 CNIH1 B3GNT3 KDELR3 B3GNT2 TMEM115 STT3A CNIH2 CNIH3 MCFD2 RARA PPP6C PPP6R1 PPP6R3 TRAPPC6A TRAPPC6B DAD1 GORASP1 SEC22A DDOST SEC22C MGAT4C MGAT4A TIMP1 MGAT4B FOLR1 BET1 RAB24 RAB2A RAB10 CSF1 SOCS5 COMMD9 B4GALT2 B4GALT3 B4GALT1 USP13 MDC1 TNKS TNKS2 RNF146 MAGT1 OTUD3 QSOX1 CTSC COMMD3 DAXX RRAGA NEDD8 CAND1 CST3 B4GALT6 TP53 B4GALT4 B4GALT5 CP TF RAB9B BARD1 ST6GALNAC1 GMPPB ST6GALNAC2 C4A FPGT CMAS GMPPA PGM3 NPL CREBBP NANP GNPNAT1 NUDT14 NEU4 ALG5 ST8SIA4 SLC17A5 ALG10 ST8SIA5 RENBP ALG10B ST3GAL5 TSTA3 ST8SIA6 UAP1 NANS ST6GAL1 FUOM ST6GAL2 GMDS AMDHD2 ST8SIA1 FUK ST8SIA2 PMM1 ST8SIA3 GFPT2 ST6GALNAC3 ST6GALNAC4 NAGK ST6GALNAC5 DOLPP1 GNE HLA-A CD59 CD55 CHM BRCA1 CKAP4 RAB3A ING2 DDB2 ARRB2 TCEB2 TCEB1 TAF9B NPM1 TOP2A CDKN2A COL7A1 FN1 HIPK2 TRIM25 DDX58 USP7 IGFBP3 USP2 USP18 UBE2N ANK1 GALNT11 GALNT14 GALNT13 GALNT16 GALNT15 GALNT18 GALNT10 POFUT2 WBSCR17 GYLTL1B B3GALNT2 GALNTL5 GALNTL6 B3GNTL1 GALNT9 GALNT8 POMGNT2 B3GNT9 B3GNT8 B3GNT6 B3GNT5 CHST4 GCNT1 GCNT3 GCNT4 GCNT7 GALNT7 GALNT6 GALNT5 GALNT4 A4GNT POMK MDM2 MDM4 PTEN RABGGTB RABGGTA CCNA2 CCNA1 SMC3 CDC20 BIRC5 DYNC1LI1 APP DYNC1LI2 ARF4 CTSZ ARRB1 CDCA8 DMP1 AURKB AURKA RAD21 STAG1 STAG2 NAPA RAB5C TGOLN2 TAF10 SMC1A DYNLL2 PML RAB11A INCENP MATN3 TRAF3 SPP1 GBF1 DYNC1I1 GOLGB1 ALPI LTBP1 TGFA AREG BMP4 FBN1 PNPLA2 SERPINC1 PROS1 KNG1 NFKBIA IKBKG IKBKE TOPORS DCAF7 TRIM27 VHL TUBB6 FGA SERPIND1 TUBB3 UBE2C F10 TUBB1 FBXO4 UBE2E1 UBE2D1 FBXO6 SOCS3 FGG F2 FBXW4 CDC34 F5 FBXW5 F7 FBXW10 FBXW7 BCL10 CDK1 FBXW9 F8 FBXW2 PROC F9 FBXL3 FBXL5 TUBA1C TUBA1B TUBA1A TUBB2B TUBB2A USP11 TUBA3E CFTR TUBB4B TUBB4A ANK2 ANK3 NUP107 NUP188 PIGS CPM LY6K EID3 PIGU SPARCL1 PIGT PGAP1 HRC PIGO DDA1 NUP62 LRRC49 PSCA PIGN JOSD2 JOSD1 GPAA1 NDC1 PIGP PTRH2 NUP214 SAR1B PIGZ FSTL1 SEC13 SPP2 MSLN PIGW GOLM1 PIGV TTLL7 NUP133 USP33 PIGY SPSB3 NUP210 TTLL6 PRSS21 PIGX TTLL5 TTLL4 FCGR3B TTLL3 PRND TTLL2 TECTA TTLL1 NUP93 TECTB CCDC8 CD52 NUP50 TTLL9 PLAUR TTLL8 RTN4RL2 ATXN3L NUP54 IZUMO1R AGTPBP1 ALPPL2 PIGC MUL1 NAE1 DPM1 BMP15 DPM2 PIGB COMMD10 NSMCE4A DPM3 TOP1 NRN1L ITIH2 CEACAM7 USP9X FEM1C RTN4RL1 B4GAT1 FEM1A CD109 PIGA FEM1B NICN1 CEACAM5 LY6D LGALS1 POM121 PIGK NSMCE2 NUP205 SPACA4 NSMCE1 PIGM MXRA8 AAAS PIGL SNX3 LY6H COMMD8 NUP160 PIGG HLTF PIGF ZBED1 RCE1 GPLD1 NUP85 LY6E RAB27B TPR PIGH CALU NRN1 OTUD7A NUP88 MFI2 IDE NUP43 CHRDL1 NTM RAB22A TEX101 LYPD1 COMMD2 RAE1 LYPD2 COMMD1 LYPD3 COMMD6 CDH2 RANBP2 THY1 COMMD7 LYPD4 COMMD4 LYPD5 COMMD5 NUP155 ART3 RNF144A ART4 KIN ENAM OTOA MFGE8 LY6G6C SATB2 NUP153 LY6G6D STAMBPL1 OPCML NTNG1 PEX10 NTNG2 PEX12 PEX13 NEGR1 PEX14 CNTN5 VCPIP1 GP2 FAM175B LSAMP MYSM1 NUP35 PLET1 VCPKMT VNN3 NUPL2 PEX2 XPNPEP2 RCN1 RAET1G LYPD6B VIMP NUP37 OTUB1 RAET1L ALPL OTUB2 CNTN3 RAB40A RPN2 CNTN4 RAB40B RPN1 RAB40C ULBP2 MDGA2 TNIP1 MDGA1 TNIP3 RECK DCAF8 PPARG SPRN SMC5 SMC6 PPARA ALG2 TPGS1 DCAF5 DCAF4 TPGS2 DCAF6 USP17L4 USP17L5 EVA1A USP17L8 CHGB WSB2 RNF128 SERPINA10 PRSS23 RNF152 SHPRH WDR20 AFP METTL21A NDNL2 SUMO1 CHML SUMO3 APOL1 SUMO2 USP17L2 UBA2 USP17L3 KTN1 USP17L1 SAE1 AGBL5 AGBL4 AGBL1 AGBL3 AGBL2 NUCB1 RAB3B RAB3C N6AMT2 RAB43 RAB42 RAB2B STAM PIAS4 IGFBP5 USP5 IGFBP4 USP3 RNF40 RAB32 RAB34 RAB35 FKBP8 RAB38 STAMBP STAM2 CUL9 WDTC1 AMBN TMEM132A RNF181 APC CCDC22 CYR61 METTL10 MEPE DPH1 METTL22 DPH2 EP300 PTP4A2 DPH3 METTL20 DPH5 RAB4B TULP4 DPH6 TTL DPH7 RAB21 DCAF16 DCAF17 RAB20 RAB25 RAB26 RAB23 EEF2KMT RAB29 DCAF10 DCAF11 VGF RNF20 RAB15 RAB12 RAB13 RAB19 RAB17 TTLL10 USP17L30 YOD1 TTLL11 TTLL12 OBSL1 DCUN1D5 DCUN1D3 DCUN1D4 ETFB DCUN1D1 SEC31A DCUN1D2 STC2 ZRANB1 RAB39B PUM2 RANGAP1 TOP2B ANKRD9 UBXN7 RAB8B RAB33A WAC FAM20C VWA1 FAM20A RAB7B USP17L27 USP17L26 USP17L29 USP17L28 USP17L21 USP17L20 USP17L22 TUBB8P12 TUBB8 USP17L25 USP17L24 USP17L15 USP17L18 USP17L17 USP17L19 USP17L10 USP17L12 USP17L11 USP17L13 RAB11B RAB9A APLP2 SHISA5 SCG3 SCG2 UBD TMEM129 AMELX SMAD1 USP37 VCAN USP47 USP48 USP49 USP42 STS USP44 AMTN USP14 USP16 USP12 USP19 LAMC1 USP24 USP25 USP26 USP20 USP8 USP28 NEURL2 GRIA1 SDC2 NEU2 NEU3 NEU1 LAMB2 APOE LAMB1 APOB MUC20 B4GALNT2 NSF BST1 SOCS2 CISH NAPB GOSR1 NAPG RAB41 MAN2A2 HNRNPK MAN1A2 HNRNPC MAN2A1 MAN1C1 STX5 MAN1A1 YKT6 COG8 CETN2 COG7 COG6 CCP110 COG5 COG4 ACTR1A COG3 COG2 RAB39A COG1 BET1L RAB33B RAB30 RAB8A RAB36 FBXW11 VDAC3 CSNK1D VDAC2 UBE2I DYNLL1 DYNC1I2 DCTN2 DCTN3 HERC2 NFRKB DYNC1H1 PRKDC COPS7B XPC COPS7A ACTB BRCC3 HGS RAB5A HIST1H2AE SPTAN1 TP53BP1 HIST1H2AD HIST3H2BB RAB7A HIST1H2AC HIST1H2AB XRCC4 HIST1H2AJ INO80 HIST1H2BF HIST1H2BE HIST1H2BH HIST1H2BG HIST1H2BB SATB1 BAP1 HIST1H2BA RAD18 WDR48 HIST1H2BD HIST1H2BC DNMT1 BABAM1 UIMC1 PARP1 ACTL6A SUDS3 RNF168 DDB1 HIST1H4K UBE2D2 GPS1 UBE2D3 HIST1H4L HIF3A CUL2 ST3GAL4 HIST1H4A ST3GAL6 HIST1H4B MCRS1 CGA HIST1H4H ST3GAL1 HIST1H4I HIST1H4J ST3GAL2 HIST1H4C ST3GAL3 HIST1H4D HIST1H4E HIST1H4F HIST2H2AA3 YY1 HIST2H2AA4 SPTB RUVBL1 CHD3 SPTBN4 HIST2H2AC PIAS3 SPTBN5 SPTA1 SIN3A SPTBN1 PIAS1 SPTBN2 DNMT3B UBE2V2 NCOR2 DNMT3A INO80C INO80B INO80E INO80D IFIH1 RNF135 HIST2H2BE MAVS KAT2B CLSPN UBE2B KAT2A HIST4H4 COPS4 HIST1H2BN COPS3 HIST1H2BM IGFBP1 COPS6 HDAC2 COPS5 HIST1H2BO UBE2T NR1H2 HIST1H2BJ COPS2 HDAC1 FAM175A HIST1H2BI ATXN3 ANO8 COPS8 HIST1H2BL UFD1L HIST1H2BK HIST2H4A FBXO32 POLB HIST2H4B MTA1 TDG ACTR5 RAD23A ACTR8 RBBP7 DTL USP10 SUZ12 TFPT RAB4A RAD52 CUL4A BRE IL33 ERCC8 CUL4B RWDD3 APOA2 APOA1 APOA5 EEF1A1 EEF2 RIPK2 NOD1 NOD2 RAB14 TNIP2 TFAP2C FBXL7 RHOT1 FBXL18 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 ADAM10 PSMA5 PSMA6 PSMA3 PSMA4 LHB PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 SMAD2 UBA52 SMAD3 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 VNN1 PSMD13 VNN2 PSMA7 LRR1 PSMB10 PSMA8 CCNF KEAP1 PSMB6 UBE2L3 PSMB7 SMURF2 PSMB4 PSMB5 FBXO7 PSMB2 FBXO9 UBB PSMB3 WSB1 FBXO2 RFWD2 RNF123 UBC PSMB1 PSMF1 RPS27A UBE2J2 HSPA8 SHFM1 SIAH2 PSMB8 PSMB9 PSMC5 FBXL8 PSMC6 FBXL4 PSMC3 PSMC4 PSMC1 PSMC2 NR3C1 KDELR1 GPR75-ASB3 LRRC41 GAN KDELR2 KLHL2 KLHL3 EPAS1 UBE2G1 UBE2G2 HIF1A COPB2 KLHL9 COPA SPSB2 TMED10 SPSB1 COPB1 PCSK9 KBTBD6 KLHL5 KBTBD8 SPSB4 PENK RAB6B FBXO27 COPE FBXO21 UBE2Z FBXO22 HDAC4 PARK2 CAPZB FBXW12 TMED3 HDAC7 FBXW8 UBE2E3 FBXO17 TMED7 TMED9 FBXO15 COPZ2 LMO7 FBXO10 P4HB FBXO11 ARFGAP3 KLHL41 CAMKMT KLHL42 COPZ1 ARFGAP2 BTRC KCTD7 CUL5 SKP1 UBA6 TRAF6 RBX1 SEC22B KLHL11 ARF5 KLHL13 TAB1 MAP3K7 FBXO44 DCTN6 FBXO41 RAB1A FBXO40 DCTN5 LOSS OF FUNCTION OF SMAD2 3 IN CANCER%REACTOME DATABASE ID RELEASE 72%3304349 Loss of Function of SMAD2 3 in Cancer SMAD2 TGFB1 SMAD3 SMAD4 TGFBR1 TGFBR2 RESPONSE OF EIF2AK1 (HRI) TO HEME DEFICIENCY%REACTOME%R-HSA-9648895.2 Response of EIF2AK1 (HRI) to heme deficiency EIF2S2 EIF2S1 EIF2S3 ATF5 ATF3 TRIB3 DDIT3 GRB10 EIF2AK1 ATF4 CHAC1 PPP1R15A CEBPB CEBPG ASNS ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS%REACTOME%R-HSA-2029485.1 Role of phospholipids in phagocytosis IGKV3-11 PRKCD PPAPDC1A PPAPDC1B PLCG2 CD3G ITPR1 PIK3R1 FCGR3A ITPR2 IGKV2-28 ITPR3 PIK3R2 PIK3CA PLCG1 SYK IGHG4 IGKV3D-20 IGHG1 IGHG2 IGKV1-12 AHCYL1 IGKV2D-28 IGKV4-1 PIK3CB IGKV2D-30 FCGR1A PLD4 PRKCE IGKV5-2 PLD1 PLA2G6 PLD3 FCGR2A PLD2 G ALPHA (12 13) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 72%416482 G alpha (12 13) signalling events VAV1 VAV2 ECT2 ARHGEF33 ARHGEF35 ARHGEF37 ARHGEF7 ARHGEF39 ARHGEF38 NET1 ROCK1 RASGRF2 ROCK2 RHOC ARHGEF10L RHOB GNA12 AKAP13 MCF2L ARHGEF11 TIAM1 ARHGEF10 ARHGEF12 PLEKHG2 ARHGEF15 ARHGEF17 PLEKHG5 ARHGEF16 ARHGEF19 ADRA1D ARHGEF9 ADRA1B ARHGEF3 ADRA1A ARHGEF4 ARHGEF1 ARHGEF2 SOS2 ARHGEF5 FGD1 FGD2 FGD3 GNA13 FGD4 MCF2 GNG10 GNG12 GNG11 GNG13 GNB2 GNB1 GNB4 GNB3 GNB5 GNGT1 GNGT2 SOS1 TBXA2R TRIO ARHGEF18 ITSN1 GNG3 RHOA GNG2 PREX1 GNG5 ARHGEF40 GNG4 GNG7 GNG8 OBSCN NGEF BTK PLXNB1 ARHGEF6 ARHGEF26 KALRN TIAM2 VAV3 ABR PHASE 1 - INACTIVATION OF FAST NA+ CHANNELS%REACTOME DATABASE ID RELEASE 72%5576894 Phase 1 - inactivation of fast Na+ channels KCNIP4 KCND1 KCND2 KCND3 KCNIP1 KCNIP2 KCNIP3 MECP2 REGULATES TRANSCRIPTION OF GENES INVOLVED IN GABA SIGNALING%REACTOME%R-HSA-9022927.1 MECP2 regulates transcription of genes involved in GABA signaling GAD1 GAD2 NTF4 ACTIVATES NTRK2 (TRKB) SIGNALING%REACTOME%R-HSA-9026357.1 NTF4 activates NTRK2 (TRKB) signaling NTRK2 NTF4 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME DATABASE ID RELEASE 72%3359463 Defective CUBN causes hereditary megaloblastic anemia 1 GIF AMN CUBN SURFACTANT METABOLISM%REACTOME%R-HSA-5683826.3 Surfactant metabolism GATA6 ZDHHC2 DMBT1 P2RY2 LMCD1 NAPSA CCDC59 ADRA2C PGA3 CECR1 PGA5 ADRA2A PGA4 TTF1 ADGRF5 ABCA3 SLC34A2 SLC34A1 ADORA2A ADORA2B SFTA3 SFTPB SFTPA2 SFTPC SFTPD CSF2RB SFTPA1 CSF2RA CTSH CKAP4 EVASION OF ONCOGENE INDUCED SENESCENCE DUE TO P16INK4A DEFECTS%REACTOME%R-HSA-9630750.3 Evasion of Oncogene Induced Senescence Due to p16INK4A Defects CDK6 CDK4 CDKN2A DEFECTIVE AVP DOES NOT BIND AVPR2 AND CAUSES NEUROHYPOPHYSEAL DIABETES INSIPIDUS (NDI)%REACTOME DATABASE ID RELEASE 72%9036092 Defective AVP does not bind AVPR2 and causes neurohypophyseal diabetes insipidus (NDI) AVP AVPR2 DEFECTIVE SLC26A3 CAUSES CONGENITAL SECRETORY CHLORIDE DIARRHEA 1 (DIAR1)%REACTOME DATABASE ID RELEASE 72%5619085 Defective SLC26A3 causes congenital secretory chloride diarrhea 1 (DIAR1) SLC26A3 ANTAGONISM OF ACTIVIN BY FOLLISTATIN%REACTOME%R-HSA-2473224.2 Antagonism of Activin by Follistatin FST INHBB FSTL3 INHBA WNT LIGAND SECRETION IS ABROGATED BY THE PORCN INHIBITOR LGK974%REACTOME DATABASE ID RELEASE 72%5340573 WNT ligand secretion is abrogated by the PORCN inhibitor LGK974 PORCN RNA POLYMERASE I TRANSCRIPTION%REACTOME DATABASE ID RELEASE 72%73864 RNA Polymerase I Transcription RBBP4 TAF1B TAF1C TAF1A TWISTNB POLR2E POLR2F POLR2H RBBP7 MTA2 MTA3 POLR2K POLR2L MBD3 MBD2 GTF2H1 GTF2H2 GTF2H3 GTF2H4 GATAD2B GTF2H5 GATAD2A ERCC3 ERCC2 ERCC6 PTRF CCNH EHMT2 TTF1 HIST1H2AE HIST1H2AD HIST3H2BB HIST1H2AC HIST1H2AB HIST1H2AJ CHD4 CD3EAP HIST2H3A HIST1H2BF HIST1H2BE HIST1H2BH HIST1H2BG HIST2H3D HIST1H2BB HIST1H2BA HIST2H3C HIST1H2BD HIST1H2BC H2AFB1 HIST1H3J HIST1H3A HIST1H3F HIST1H3G HIST1H3H HIST1H3I HIST1H3B HIST1H3C HIST1H3D HIST1H3E H3F3B HIST1H4K CBX3 HIST1H4L RRN3 H3F3A MAPK3 H2BFS HIST1H4A CDK7 HIST1H4B HIST1H4H HIST1H4I HIST1H4J HIST1H4C MNAT1 HIST1H4D HIST1H4E HIST1H4F HIST2H2AA3 HIST2H2AA4 CHD3 HIST2H2AC ZNRD1 H2AFJ UBTF TBP H2AFZ H2AFX H2AFV HIST2H2BE KAT2B KAT2A POLR1A HIST4H4 POLR1B POLR1C POLR1E HIST1H2BN HIST1H2BM HDAC2 HIST1H2BO HIST1H2BJ HDAC1 HIST1H2BI HIST1H2BL HIST1H2BK HIST2H4A TAF1D HIST2H4B MTA1 DEFECTIVE HK1 CAUSES HEXOKINASE DEFICIENCY (HK DEFICIENCY)%REACTOME DATABASE ID RELEASE 72%5619056 Defective HK1 causes hexokinase deficiency (HK deficiency) HK1 GROWTH HORMONE RECEPTOR SIGNALING%REACTOME DATABASE ID RELEASE 72%982772 Growth hormone receptor signaling LYN STAT1 SOCS1 STAT5A STAT5B SOCS3 IRS1 ADAM17 IRS2 PTPN6 JAK2 PTPN1 SOCS2 CSH1 STAT3 PRL CISH PRLR GHR GH2 GH1 MAPK1 MAPK3 FGFR1 MUTANT RECEPTOR ACTIVATION%REACTOME%R-HSA-1839124.2 FGFR1 mutant receptor activation BAG4 STAT1 ERLIN2 CUX1 FGFR1OP PIK3R1 TRIM24 FGF6 PIK3CA FGF9 FGF20 FGF1 FGF2 FGF23 FGF4 BCR LRRFIP1 STAT5A STAT5B CPSF6 ZMYM2 FGFR1OP2 MYO18A FGFR1 GAB2 STAT3 HYDROLYSIS OF LPC%REACTOME%R-HSA-1483115.3 Hydrolysis of LPC PLA2G4B PLA2G4C PLA2G4A GPCPD1 PLA2G15 PLA2G4F PLBD1 PLA2G4D TCF7L2 MUTANTS DON'T BIND CTBP%REACTOME%R-HSA-5339700.2 TCF7L2 mutants don't bind CTBP CTBP1 TCF7L2 CTBP2 TANDEM PORE DOMAIN POTASSIUM CHANNELS%REACTOME%R-HSA-1296346.1 Tandem pore domain potassium channels KCNK17 KCNK18 KCNK10 KCNK1 KCNK6 KCNK2 KCNK13 KCNK3 KCNK7 KCNK4 KCNK9 KCNK16 TFAP2 (AP-2) FAMILY REGULATES TRANSCRIPTION OF CELL CYCLE FACTORS%REACTOME DATABASE ID RELEASE 72%8866911 TFAP2 (AP-2) family regulates transcription of cell cycle factors TFAP2A TFAP2C MYC KDM5B CDKN1A SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION%REACTOME%R-HSA-416550.2 Sema4D mediated inhibition of cell attachment and migration SEMA4D ARHGAP35 RND1 PLXNB1 MET RHOA RAC1 RRAS DEPYRIMIDINATION%REACTOME%R-HSA-73928.1 Depyrimidination TDG TINF2 NEIL3 TERF2IP NEIL2 NEIL1 HIST1H2AE NTHL1 HIST1H2AD HIST3H2BB HIST1H2AC ACD HIST1H2AB HIST1H2AJ HIST1H2BF HIST1H2BE SMUG1 HIST1H2BH HIST1H2BG HIST1H2BB HIST1H2BA HIST1H2BD OGG1 HIST1H2BC H2AFB1 HIST3H3 TERF1 TERF2 POT1 HIST1H4K HIST1H4L H2BFS HIST1H4A MBD4 HIST1H4B HIST1H4H HIST1H4I HIST1H4J HIST1H4C HIST1H4D HIST1H4E HIST1H4F HIST2H2AA3 HIST2H2AA4 HIST2H2AC H2AFJ H2AFZ H2AFX H2AFV HIST2H2BE HIST4H4 HIST1H2BN HIST1H2BM HIST1H2BO HIST1H2BJ HIST1H2BI HIST1H2BL HIST1H2BK HIST2H4A HIST2H4B INTERACTION BETWEEN L1 AND ANKYRINS%REACTOME%R-HSA-445095.1 Interaction between L1 and Ankyrins SCN7A SCN10A ANK2 ANK3 SCN8A ANK1 SPTB SPTBN4 SPTBN5 NFASC KCNQ2 SPTA1 KCNQ3 SCN3B SPTAN1 SPTBN1 SCN3A SPTBN2 SCN2A SCN2B L1CAM NRCAM SCN11A SCN5A SCN9A SCN1B SCN1A SCN4A SCN4B PROPIONYL-COA CATABOLISM%REACTOME%R-HSA-71032.2 Propionyl-CoA catabolism PCCA PCCB MMAA MCEE MUT ACTIVATION OF RAC1 DOWNSTREAM OF NMDARS%REACTOME DATABASE ID RELEASE 72%9619229 Activation of RAC1 downstream of NMDARs CAMKK1 GIT1 CAMKK2 CAMK1 RAC1 PHOSPHORYLATION OF EMI1%REACTOME%R-HSA-176417.2 Phosphorylation of Emi1 CDK1 FZR1 CDC20 PLK1 FBXO5 CCNB1 TRUNCATED APC MUTANTS DESTABILIZE THE DESTRUCTION COMPLEX%REACTOME DATABASE ID RELEASE 72%4839744 truncated APC mutants destabilize the destruction complex CSNK1A1 PPP2CA PPP2CB PPP2R5B PPP2R5A PPP2R5D GSK3B PPP2R5C PPP2R1B PPP2R1A AMER1 AXIN1 APC PPP2R5E ARYL HYDROCARBON RECEPTOR SIGNALLING%REACTOME DATABASE ID RELEASE 72%8937144 Aryl hydrocarbon receptor signalling AIP AHRR ARNT AHR ARNT2 HSP90AB1 PTGES3 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION%REACTOME DATABASE ID RELEASE 72%3134963 DEx H-box helicases activate type I IFN and inflammatory cytokines production NFKB1 NFKB2 DHX36 IRF7 MYD88 DHX9 RELA GPVI-MEDIATED ACTIVATION CASCADE%REACTOME%R-HSA-114604.5 GPVI-mediated activation cascade PDPK1 LYN VAV1 VAV2 PTPN11 RAC2 PLCG2 RHOG PIK3CG PTPN6 PIK3R1 RHOB PIK3R2 PIK3CA CDC42 SYK C6orf25 PDPN CLEC1B GP6 FYN PIK3R3 PRKCZ RHOA PIK3R6 PIK3R5 PIK3CB LAT RAC1 FCER1G LCP2 VAV3 LCK HIV ELONGATION ARREST AND RECOVERY%REACTOME%R-HSA-167287.3 HIV elongation arrest and recovery GTF2F1 GTF2F2 POLR2A POLR2B TCEB3C POLR2C POLR2D TCEB3B POLR2G POLR2E NELFB POLR2F NELFA NELFCD POLR2H POLR2I POLR2J NELFE POLR2K TCEB3CL2 POLR2L TCEB3 TCEB2 TCEB1 TCEB3CL CDK9 TCEA1 CCNK CCNT2 ELL CCNT1 SSRP1 CTDP1 SUPT16H SUPT4H1 SUPT5H DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX%REACTOME DATABASE ID RELEASE 72%195253 Degradation of beta-catenin by the destruction complex PSMD3 CUL1 PSMD1 PPP2R5B PPP2R5A PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PPP2R5C PSME3 PSME4 PSME1 PSME2 UBA52 PSMD10 PPP2R1B PSMB11 PPP2R1A PSMD12 PSMD11 PSMD14 PSMD13 APC PSMA7 PSMB10 CSNK1A1 PSMA8 FRAT1 FRAT2 PSMB6 PPP2R5D CTBP1 PSMB7 PSMB4 PSMB5 PSMB2 CTBP2 UBB AES PSMB3 CTNNB1 UBC PSMB1 PSMF1 RPS27A SHFM1 PSMB8 PSMB9 PSMC5 PSMC6 PSMC3 PSMC4 TLE4 PPP2CA PSMC1 TLE3 PPP2CB PSMC2 TLE2 TLE1 ZRANB1 TCF7 TCF7L2 GSK3B LEF1 TCF7L1 BTRC SKP1 HDAC1 PSMD8 PSMD9 PSMD6 RBX1 PSMD7 PSMD4 AMER1 PSMD5 AXIN1 PSMD2 PPP2R5E MAPK3 (ERK1) ACTIVATION%REACTOME%R-HSA-110056.2 MAPK3 (ERK1) activation CDK1 JAK2 IL6R MAP2K1 JAK1 IL6 PTPN11 MAPK3 TYK2 PCNA-DEPENDENT LONG PATCH BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 72%5651801 PCNA-Dependent Long Patch Base Excision Repair LIG1 RPA1 RPA2 POLE POLD3 RFC1 POLD4 POLE4 RPA3 POLD1 APEX1 POLD2 RFC5 RFC3 POLE2 RFC4 POLE3 RFC2 FEN1 POLB PCNA CARGO CONCENTRATION IN THE ER%REACTOME DATABASE ID RELEASE 72%5694530 Cargo concentration in the ER CNIH3 MCFD2 SEC24B SEC24A SERPINA1 STX5 FOLR1 TMED10 SEC24D SEC24C CTSZ GOSR2 LMAN1L LMAN2L SAR1B COL7A1 TMED2 SEC23A MIA2 MIA3 LMAN1 LMAN2 TGFA AREG F5 CD59 F8 CTSC SEC22B PREB CNIH1 GRIA1 CNIH2 LOSS OF MECP2 BINDING ABILITY TO THE NCOR SMRT COMPLEX%REACTOME DATABASE ID RELEASE 72%9022537 Loss of MECP2 binding ability to the NCoR SMRT complex HDAC3 NCOR1 TBL1X TBL1XR1 GPS2 NCOR2 DEFECTIVE SLC20A2 CAUSES IDIOPATHIC BASAL GANGLIA CALCIFICATION 1 (IBGC1)%REACTOME DATABASE ID RELEASE 72%5619111 Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1) SLC20A2 SIGNALING BY NTRKS%REACTOME DATABASE ID RELEASE 72%166520 Signaling by NTRKs RAPGEF1 MAP2K1 MAP2K2 DNM1 BRAF DNM3 PPP2R1B NTRK2 PPP2R1A NTF3 RALA SH3GL2 RALGDS DNAL4 DOCK3 PPP2R5D GRIN2B PTPRO RALB KIDINS220 RIT1 ADCYAP1 RIT2 ADCYAP1R1 PTPRS NTRK1 BAX PPP2CA PPP2CB MAP2K5 NELFB HRAS ADORA2A NRAS CLTC CLTA AP2A1 PIK3CB AP2B1 YWHAB AP2A2 AP2S1 AP2M1 SRC RAC1 FURIN PCSK6 NGF PCSK5 MAPKAPK3 PTPN11 CRK SHC2 PIK3R2 TIAM1 ATF1 BDNF SH3GL3 ATF2 NAB1 NAB2 CHD4 ELK1 NTRK3 RPS6KA3 LYL1 RPS6KA5 RPS6KA2 RPS6KA1 EP300 JUNB DUSP4 MEF2A MEF2C MAPK12 CRKL RAP1A DUSP3 MAPK13 TCF12 FOS IRS1 VRK3 F3 IRS2 DUSP6 DNM2 DUSP7 ARC CREB1 VGF MAPKAPK2 SGK1 TRIB1 TPH1 RRAD SRF ASCL1 MAPK7 SHC3 MAPK1 MEF2D MAPK3 EGR1 EGR2 JUND EGR3 EGR4 MAPK14 FOSL1 MAPK11 FRS2 REST FRS3 CDK5 ID2 ID1 ID4 FOSB ID3 CDK5R2 CDK5R1 SHC1 GAB1 PIK3R1 PIK3CA PLCG1 SOS1 RHOA STAT3 NTF4 VLDLR INTERNALISATION AND DEGRADATION%REACTOME%R-HSA-8866427.3 VLDLR internalisation and degradation CLTA AP2A1 PCSK9 AP2B1 VLDLR AP2A2 NR1H2 AP2S1 AP2M1 MYLIP NR1H3 CLTC LXR-MEDIATED SIGNALING%REACTOME DATABASE ID RELEASE 72%9024446 LXR-mediated signaling TNRC6A TNRC6B TBL1X UGT1A3 PCK1 APOE TBL1XR1 KDM4A APOC2 NCOA1 MYLIP SCD NCOR2 HDAC3 NCOR1 ANGPTL3 ABCA1 ABCG1 CETP EP300 MOV10 AGO3 AGO4 PLIN1 RXRB FABP6 AGO1 KDM1A RXRA AGO2 KDM1B NRIP1 APOC4 KDM3A APOC1 NR1H2 APOD TNRC6C GPS2 FASN ABCG8 ABCG5 NR1H3 ARL4C EEPD1 BILE ACID AND BILE SALT METABOLISM%REACTOME%R-HSA-194068.1 Bile acid and bile salt metabolism ALB PTGIS ACOX2 CYP46A1 SLCO1A2 SLC10A1 SLC10A2 HSD3B7 CH25H OSBPL9 NCOA1 SLC27A2 SLC27A5 OSBPL7 NCOA2 OSBPL6 OSBPL3 OSBPL2 AKR1D1 FABP6 RXRA BAAT CYP7B1 HSD17B4 OSBP ACOT8 STARD5 AKR1C1 AMACR AKR1C3 ABCB11 AKR1C2 NR1H4 CYP7A1 CYP39A1 SLCO1B1 AKR1C4 SLCO1B3 CYP8B1 OSBPL1A CYP27A1 ABCC3 ACTIVATION OF BH3-ONLY PROTEINS%REACTOME%R-HSA-114452.2 Activation of BH3-only proteins BMF AKT1 BCL2L11 YWHAG BAD YWHAZ BCL2 YWHAH TP53 PMAIP1 MAPK8 TFDP1 TP53BP2 SFN TFDP2 BID E2F1 TP73 DYNLL1 YWHAB DYNLL2 YWHAE AKT2 AKT3 PPP1R13B PPP3CC BBC3 YWHAQ TP63 PPP3R1 REGULATION OF TP53 EXPRESSION%REACTOME DATABASE ID RELEASE 72%6804754 Regulation of TP53 Expression PRDM1 TP53 AUTOINTEGRATION RESULTS IN VIRAL DNA CIRCLES%REACTOME%R-HSA-177539.2 Autointegration results in viral DNA circles PSIP1 BANF1 HMGA1 BIOSYNTHESIS OF DHA-DERIVED SPMS%REACTOME%R-HSA-9018677.1 Biosynthesis of DHA-derived SPMs EPHX2 CYP3A4 ALOX15 ALOX12 CYP2C9 LTA4H CYP2C8 CYP2D6 GSTM4 HPGD ALOX5 PTGS2 LTC4S CYP1A2 CYP1A1 CYP2E1 U12 DEPENDENT SPLICING%REACTOME%R-HSA-72165.1 U12 Dependent Splicing SNRNP48 POLR2E POLR2F POLR2H SF3B1 POLR2K POLR2L PDCD7 EFTUD2 TXNL4A SNRNP35 ZCRB1 PRPF6 SNRNP25 SNRNP200 RNPC3 PRPF8 ZMAT5 ZRSR2 NCBP1 NCBP2 GTF2F1 LSM2 GTF2F2 POLR2A POLR2B POLR2C POLR2D POLR2G POLR2I POLR2J DDX42 YBX1 SRSF2 SRSF6 SRSF7 SRSF1 SNRPD2 SNRPD1 SNRPD3 NHP2L1 SNRPG SNRPE SF3B4 SNRPF SF3B5 SF3B2 SNRPB SF3B3 SF3B6 DDX23 SNRNP40 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME%R-HSA-110381.1 Resolution of AP sites via the single-nucleotide replacement pathway XRCC1 APEX1 LIG3 POLB LEISHMANIA PHAGOCYTOSIS%REACTOME DATABASE ID RELEASE 72%9664417 Leishmania phagocytosis VAV1 WIPF1 VAV2 WIPF2 FGR WIPF3 ELMO1 ELMO2 CRK DOCK1 ARPC1B ARPC1A WAS MYO9B ACTG1 ACTB NCKIPSD CDC42 ARPC4 NCKAP1L ARPC5 FYN ARPC2 IGHG4 WASF1 ARPC3 WASF2 IGHG1 ACTR3 IGHG2 ACTR2 WASF3 IGKV1-12 MYH2 MYO10 MYO1C BAIAP2 PTK2 ABI2 ABI1 IGKV2D-28 IGKV4-1 IGKV2D-30 MAPK1 MAPK3 IGKV3-11 LYN YES1 MYO5A WASL CD3G FCGR3A IGKV2-28 SYK IGKV3D-20 HCK ABL1 MYH9 CYFIP2 CYFIP1 NCKAP1 BRK1 BTK IGKV5-2 RAC1 NCK1 VAV3 TOLL-LIKE RECEPTOR CASCADES%REACTOME DATABASE ID RELEASE 72%168898 Toll-like Receptor Cascades CUL1 EEA1 RBSN ITGAM MAP2K1 ITGB2 DNM1 DNM3 CD180 PLCG2 APOB BPI MAPK8 PPP2R1B PPP2R1A APP RELA PIK3R4 PPP2R5D IRAK3 TIRAP TLR1 BIRC2 SIGIRR BIRC3 UNC93B1 CTSV TLR6 CNPY3 TLR2 CTSS PTPN4 CTSL CTSK CTSB LGMN TRAF3 TLR3 PPP2CA HMGB1 PPP2CB IKBKB NKIRAS1 NKIRAS2 MAP3K8 MAP2K3 CHUK MAP2K4 RIPK2 IRAK4 PELI1 TLR9 TLR8 TLR7 UBE2V1 PELI3 PELI2 NFKB1 NOD1 NFKB2 TLR10 NOD2 AGER TLR5 MAPK9 IRAK1 S100A12 MAP2K7 MAP3K1 CD36 S100B MAPK10 TNIP2 JUN SAA1 MYD88 NFKBIB FBXW11 SOCS1 HSP90B1 TANK ECSIT TICAM2 LY96 TICAM1 CD14 TLR4 MAPKAPK3 PTPN11 UBA52 ATF1 ATF2 NFKBIA IKBKG IKBKE ELK1 RPS6KA3 RPS6KA5 RPS6KA2 FGB RPS6KA1 FGA DUSP4 MEF2A MEF2C UBE2D1 DUSP3 FGG FOS VRK3 UBB DUSP6 DNM2 UBC DUSP7 CREB1 MAPKAPK2 RPS27A IRF3 UBE2D2 MAPK7 UBE2D3 MAPK1 MAPK3 MAPK14 MAPK11 UBE2N CASP8 RIPK1 MAP2K6 FADD PIK3C3 TBK1 RIPK3 IRF7 BTRC S100A9 SKP1 BTK S100A8 IRAK2 TRAF6 TAB3 TAB2 LY86 TAB1 MAP3K7 S100A1 LBP DEFECTIVE DOLK CAUSES DOLK-CDG (CDG-1M)%REACTOME%R-HSA-4755583.1 Defective DOLK causes DOLK-CDG (CDG-1m) DOLK DEFECTIVE SLC6A18 MAY CONFER SUSCEPTIBILITY TO IMINOGLYCINURIA AND OR HYPERGLYCINURIA%REACTOME DATABASE ID RELEASE 72%5659729 Defective SLC6A18 may confer susceptibility to iminoglycinuria and or hyperglycinuria SLC6A18 NA+ CL- DEPENDENT NEUROTRANSMITTER TRANSPORTERS%REACTOME DATABASE ID RELEASE 72%442660 Na+ Cl- dependent neurotransmitter transporters SLC6A18 SLC6A15 SLC6A14 SLC22A2 SLC22A1 SLC18A2 SLC6A20 SLC6A2 SLC6A5 SLC6A9 SLC6A13 SLC18A1 SLC6A12 SLC6A11 SLC6A6 SLC6A1 SLC6A7 SLC6A3 SLC6A19 CLEC7A (DECTIN-1) INDUCES NFAT ACTIVATION%REACTOME%R-HSA-5607763.1 CLEC7A (Dectin-1) induces NFAT activation ITPR1 ITPR2 ITPR3 PPP3CA PPP3CB NFATC2 NFATC3 NFATC1 AHCYL1 PPP3R1 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS%REACTOME%R-HSA-73817.4 Purine ribonucleoside monophosphate biosynthesis PAICS PFAS PPAT IMPDH1 IMPDH2 LHPP GART ATIC ADSSL1 ADSS ADSL GMPS DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME DATABASE ID RELEASE 72%3359462 Defective AMN causes hereditary megaloblastic anemia 1 GIF AMN CUBN DEFECTIVE SLC9A6 CAUSES X-LINKED, SYNDROMIC MENTAL RETARDATION,, CHRISTIANSON TYPE (MRXSCH)%REACTOME%R-HSA-5619092.1 Defective SLC9A6 causes X-linked, syndromic mental retardation,, Christianson type (MRXSCH) SLC9A6 NOD1 2 SIGNALING PATHWAY%REACTOME%R-HSA-168638.2 NOD1 2 Signaling Pathway CASP1 IKBKB CASP2 MAPK14 CASP4 CHUK MAPK11 CASP9 RIPK2 CARD9 UBE2N CYLD UBE2V1 CASP8 TNFAIP3 NOD1 NOD2 IRAK1 MAP2K6 IKBKG ITCH MAPK12 MAPK13 BIRC2 BIRC3 IRAK2 TRAF6 TAB3 TAB2 TAB1 MAP3K7 AAMP INTERLEUKIN-2 SIGNALING%REACTOME%R-HSA-9020558.1 Interleukin-2 signaling SHC1 IL2RB IL2 IL2RG JAK1 JAK3 IL2RA SYK STAT5A PTK2B STAT5B LCK VIF-MEDIATED DEGRADATION OF APOBEC3G%REACTOME%R-HSA-180585.1 Vif-mediated degradation of APOBEC3G PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 UBA52 PSMD10 TCEB2 PSMB11 TCEB1 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 UBB PSMB3 UBC PSMB1 PSMF1 RPS27A SHFM1 PSMB8 PSMB9 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 CUL5 PSMD8 PSMD9 PSMD6 RBX1 PSMD7 PSMD4 PSMD5 PSMD2 AMYLOID FIBER FORMATION%REACTOME DATABASE ID RELEASE 72%977225 Amyloid fiber formation NCSTN APH1B PSENEN TSPAN14 APP IAPP CALCA NPPA HSPG2 APOA1 USP9X APOA4 TSPAN5 NAT8 TTR TGFBI ITM2B CALB1 BACE1 APCS CST3 TSPAN33 GGA2 GGA1 SNCA ODAM SNCAIP SORL1 MFGE8 TSPAN15 SAA1 B2M PRL FURIN LTF ADAM10 UBA52 HIST1H2AE HIST1H2AD HIST3H2BB HIST1H2AC HIST1H2AB HIST1H2AJ HIST2H3A HIST1H2BF HIST1H2BE HIST1H2BH FGA HIST1H2BG HIST2H3D GGA3 HIST1H2BB HIST1H2BA HIST2H3C UBE2L6 HIST1H2BD GSN HIST1H2BC H2AFB1 UBB HIST1H3J HIST1H3A UBC HIST1H3F HIST1H3G HIST1H3H HIST1H3I RPS27A HIST1H3B HIST1H3C HIST1H3D HIST1H3E SIAH2 H3F3B SIAH1 HIST1H4K HIST1H4L H3F3A H2BFS HIST1H4A HIST1H4B HIST1H4H HIST1H4I HIST1H4J HIST1H4C LYZ HIST1H4D HIST1H4E HIST1H4F HIST2H2AA3 INS HIST2H2AA4 HIST2H2AC SEMG1 H2AFZ H2AFX PARK2 HIST2H2BE HIST4H4 HIST1H2BN HIST1H2BM HIST1H2BO HIST1H2BJ HIST1H2BI HIST1H2BL HIST1H2BK HIST2H4A APH1A HIST2H4B DISEASE%REACTOME DATABASE ID RELEASE 72%1643685 Disease CUL1 PRKAR2B CDH1 RPS4X PRKAR2A RPS3A HTR6 HTR7 GNAS OPN1SW CPSF4 HTR4 ADCY4 ADCY3 CHSY1 ADCY2 ADCY1 FIP1L1 PABPN1 ADCY8 ADCY7 ADCY6 ADCY5 CSNK1A1 LUM OPN1LW OPN1MW CTBP1 TIRAP TRIM28 TLR1 UNC93B1 TLR6 LRAT TLR2 FGFR1 HSPG2 RNF213 RBP4 SLC35A2 FOXO1 SLC35A1 SLC35A3 CTDP1 SLC35C1 RBP1 NCBP1 STRA6 SLC33A1 NCBP2 SUPT4H1 CD86 SUPT5H LCK CD80 GTF2F1 CD28 GTF2F2 SLCO2A1 POLR2A POLR2B NMT1 POLR2C FOXO3 POLR2D AVP POLR2G NELFB NELFA NELFCD SLC29A3 POLR2I ABCB4 POLR2J NELFE SLC27A4 PPIA NMT2 IQGAP1 PDCD6IP RANBP1 TLR10 TLR5 ABCA3 SLC5A5 AVPR1B AVPR1A SPRED3 SPRED2 SPRED1 ABCA1 DPAGT1 HRAS MPI ALG8 ALG9 ALG6 ALG14 ALG3 ALG13 ALG12 NRAS ALG1 ALG11 DHDDS NF1 MPDU1 ARF1 NUS1 PMM2 RPLP1 HEXB DOLK RFT1 HEXA MGAT2 C3 RPLP0 RPLP2 FURIN PDGFRB KIT PDGFB ESR2 STRN PIK3AP1 SLC39A4 IDUA RPS27L HHAT SHH DHH SLC16A1 IHH KRAS RPL22L1 DKK1 DKK2 DKK4 EPM2A KPNB1 KREMEN1 CYP19A1 KREMEN2 MMAA MYC SLCO1B1 SLCO1B3 CDC25A MUT SRD5A3 PCCA PCCB B3GALT6 HSP90AB1 PIK3CD EGF SHC1 GAB1 PIK3R1 CBL EGFR PIK3CA PLCG1 SOS1 CBLL1 TGFB1 SMAD4 HDAC10 TGFBR1 TGFBR2 FKBP1A FEN1 LIG1 MMAB RPL23A HIST2H2AB JAK2 CCNC FGF6 FGF9 ENTPD1 FGF20 HIST2H2BF FGF1 FGF2 FGF23 ENTPD5 FGF3 FGF22 RELA FGF10 FGF4 PPP1R3C HIST3H2A PIK3R3 CTSG SLC2A10 HIST1H2AG HIST1H2AA SLC5A1 SLC5A2 HIST1H2AM HIST1H2AL HIST1H2AI HIST1H2AH HIST1H2AK ARSB CTSA RPL27A TCF7L2 FGFR3 MYO5A WASL ESR1 NFKB1 NFKB2 HYAL1 CDK4 IDS CD36 NOTCH2 NOTCH3 SLC17A8 NOTCH4 SLC5A7 LFNG PRR5 CYFIP2 GPC1 CYFIP1 GPC3 NCKAP1 KDM7A AHCYL1 GPC2 GPC5 STX1B GPC4 ITGB3 GPC6 HDAC8 CTNND1 BRK1 PIK3CB AKT2 AKT3 MLST8 KDR RAC1 AMER1 NCK1 AXIN1 VAV3 PDPK1 KANK1 CYBA VAV1 GGT1 VAV2 ELMO1 ELMO2 MAT1A DPEP2 CRK DPEP1 DOCK1 DPEP3 MAPKAP1 ACACA CDK6 CCR5 ITPR1 ITPR2 CXCR4 ITPR3 PIK3R2 CDC42 CYP11A1 MRC1 RICTOR NCKAP1L FYN WASF1 GGT5 WASF2 PAK2 WASF3 BAIAP2 MTOR PTK2 GCLC CYP11B2 CYP11B1 ABI2 GCLM ABI1 CTNNB1 MTR LMBRD1 CYP27B1 CYP26B1 CYP24A1 CYP26C1 CYP2R1 VAMP1 RPIA GLB1 FASLG RAN RPL26L1 RPL4 SLC4A1 RPL5 RPL30 RPL3 SLC4A4 RPL32 RPL31 SLC6A19 RPL34 RPL8 SLC6A18 RPL9 RPL6 RPL7 SLC6A14 RPL36 FDXR CYP1B1 SLC9A6 RPL35 RPL38 SLC9A9 RPL37 RPL39 CUBN RPL21 RPL23 RPL22 VCP SLC26A4 SLC26A3 PSEN2 SEL1L PSEN1 DERL1 FDX1 DERL2 RPL24 SLC36A2 APH1A RNF5 RPL27 NHLRC1 RPL26 BAG4 SLC7A7 OS9 NCSTN BCL2L11 RPL29 SLC7A9 APH1B RPL28 SLC24A4 SLC20A2 PLCG2 SYVN1 MOGS SLC3A1 CANX RPL41 CALR MAN1B1 RPL3L RNF185 PSENEN VIPR1 SLC24A5 VIPR2 SCT RXFP1 RXFP2 IGHG4 FOXO6 CYSLTR1 FOXO4 GPR176 IGHG1 NR4A1 IGHG2 RPS6KB2 IGKV1-12 PTGDR LHCGR TAAR8 TAAR9 TAAR6 TAAR5 TAAR2 TAAR1 ADCYAP1 ADAM17 IGKV2D-28 IGKV4-1 IAPP ADCYAP1R1 CALCA CALCRL CALCB RPL10 IGKV2D-30 GIPR RPL12 GPR83 RPL11 GPS2 ADRB1 GPR84 RPS3 ADRB2 RPL14 CRHR1 RPL13 CRHR2 GHRHR MC2R RPS2 CALCR RPL15 RPL18 HRH2 RPL17 DRD1 IGKV3-11 RPL19 CAST DRD5 LYN CDC25B LMNB1 CD163 GOLGA4 GPR15 PORCN GOLGA2 CAPNS1 YES1 ETV6 CAPNS2 IL6 MC1R CAPN2 CAPN1 RLN2 RLN3 GPR27 FMO3 GPR25 GPR20 ADM CD3G PTH1R FMOD MC4R FCGR3A IGKV2-28 INSL3 IL10 GPR39 SYK FSHB NAGLU GPR32 AVPR2 GYG2 GLP2R GYG1 RHBDF2 RPS9 IGKV3D-20 RPS7 GPBAR1 PTH2R RPS8 GIP RPS5 MC3R RPS6 HCK ADORA2A RPSA ADRB3 ADORA2B FSHR CRH MYH9 NPSR1 PTGER4 RAMP2 RAMP3 GPR45 PTH PTGER2 PRKX PTH2 CYP4F22 PTHLH NPS GPR150 FCGR1A SLC22A12 GPHA2 P2RY11 IGKV5-2 SCTR TSHR FCGR2A GHRH ADM2 MC5R VIP CDK8 RAMP1 GPHB5 WIPF1 WIPF2 WIPF3 C3AR1 RPL7A TXNIP MEFV NOX1 AMN ARPC1B ARPC1A IL18 IL1A IL1B WAS NOXO1 MYO9B ACTG1 PYCARD RPL37A NCKIPSD DVL1 NLRP3 DVL3 ARPC4 ARPC5 ARPC2 RPL36A ARPC3 NOXA1 PSTPIP1 KCNJ11 ACTR3 RPL35A ACTR2 MYH2 MYO10 MYO1C SUGT1 CBX1 CHMP1A MCCC2 BRAP MCCC1 POMT2 GALNT12 SEMA5A SEMA5B SPON2 CYP27A1 SPON1 NOTCH1 MAP3K11 THSD7B MAML2 POMT1 MAML1 ADAMTSL1 ADAMTS4 ADAMTS5 MAOA RBPJ ADAMTS2 C1GALT1C1 ADAMTS3 HES1 ADAMTSL4 ADAMTS1 ADAMTSL3 ADAMTSL2 MUC12 DAG1 MUC13 SNW1 MUC15 THSD7A MAML3 ADAMTS8 ADAMTS9 ADAMTS6 MAMLD1 ADAMTS7 SBSPON MUCL1 MUC3A RPL39L POMGNT1 MUC5AC ADAMTS20 B3GLCT CFP ADAMTS12 THBS2 THSD1 THBS1 THSD4 ADAMTS10 ADAMTS16 ADAMTS15 ADAMTS14 GYS2 LMNA MUC1 ADAMTS13 GYS1 ADAMTS19 ADAMTS18 LARGE ADAMTS17 MUC7 MUC4 MUC6 GFPT1 GALNT3 MUC17 C1GALT1 MUC5B MUC21 DNAJC3 SLC22A18 TLN1 MAP2K1 TBL1X MAP2K2 BRAF RAF1 FAU TBL1XR1 SLC2A9 CEBPD CD4 CD8B DOCK2 SFTA3 SFTPB SFTPA2 ABCD4 SFTPC SFTPD CSF2RB B4GALT1 SFTPA1 SLC2A1 CSF2RA SLC2A2 TNKS CCNK TNKS2 SGSH SLC40A1 HEPH GUSB ABCD1 TSHB DAXX SLC24A1 SLC11A2 ABCC2 ABCC8 DCXR ATP6V1H B4GALT7 TXN PRDX2 PRELP PRDX1 CP B3GAT3 POMC JUN CREBBP PLK2 SLC17A5 AP1G1 PACS1 AP1S2 AP1B1 AP1S1 AP1S3 GNE CDKN1A HLA-A B2M CD19 CDKN1B AP1M2 ELL AP1M1 HGSNAT LY96 TICAM1 CD14 SNAP25 TLR4 TAF7L LTF SYT1 GALNS STX1A ITGA2B ARAF VAMP2 PEBP1 ARRB2 TCEB3CL2 KIAA1549 MPRIP TRIM24 KSR1 AGTRAP TCEB3 PMS2 KSR2 SND1 TCEB2 TCEB1 APBB1IP TCEB3CL CNKSR2 CNKSR1 TAF9B PAPD7 ESRP1 VCL NPM1 FAM114A2 ZC3HAV1 CDKN2A TRAK1 FXR1 RAP1B MLH1 ATG7 MARK3 FN1 QKI FAM131B AGGF1 TCEA1 KPNA7 KPNA4 KPNA5 CCNT2 KPNA2 CCNT1 KPNA3 SUPT16H TSC2 CDC25C STAT1 MSH2 FRS2 EIF2AK2 ISG15 FGF16 FGF7 FGF18 AK6 PDGFRA CDK9 AKT1S1 MDM2 TAF4B YWHAE CD9 PTEN CASP1 TCEB3C TCEB3B PPP2R5C DYNC1LI1 APP DYNC1LI2 ARRB1 TAF9 TAF1L SH3GL2 AP3B1 TAF15 TAF12 TAF13 TAF10 TXNRD1 TAF11 SSRP1 DYNLL2 PML ABCG8 ABCG5 TAF7 TRAF3 TAF6 TLR3 TAF5 TAF4 TAF3 TAF2 DYNC1I1 TAF1 CHMP2A RNF43 WNT3A FZD4 FZD6 LRP5 FZD8 LRP6 SLC34A3 SLC34A2 SLC34A1 BTC EPGN TGFA AREG HBEGF EREG AGK SOD2 CAMK4 NFKBIA IKBKG C1QBP TRIM27 FGB FGA GNAT3 VWF STAT5A STAT5B FGG IRS1 IRS2 GNAZ GNG10 TRAT1 GNG12 GNG11 GNG13 GNB2 GNB1 GNB4 GNB3 GNB5 GNGT1 GNGT2 HDAC3 GNAI3 GNAI1 GNAI2 GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 CFTR STAT3 GTF2B GTF2A1 GTF2A2 RNMT GTF2E1 GTF2E2 RNGTT SI LCT NUP107 NUP188 PSIP1 BANF1 ENO1 KPNA1 HMGA1 RHAG HK1 PPP2R1B PPP2R1A PRKACG NUP62 PRKACA PRKACB NDC1 NUP214 SEC13 G6PC NUP133 HLCS NUP210 PPP2R5D NUP93 NUP50 CPSF6 ZMYM2 FGFR1OP2 NUP54 MYO18A ALDOB DPM1 DPM2 DPM3 B4GAT1 POM121 SLC6A3 NUP205 AAAS NUP160 PPP2CA PPP2CB NUP85 TPR PGK1 NUP88 NUP43 RAE1 RANBP2 GCKR NUP155 CHST6 NUP153 GCK G6PC3 PC NUP35 NUPL2 NUP37 CYP21A2 ALG2 FZD5 WNT5A CLTC CHST3 CLTA AP2A1 AP2B1 AP2A2 AP2S1 ABCB11 AP2M1 ABCC9 SLC1A1 AGRN SLC1A3 TSG101 VPS4B VPS4A MVB12B MVB12A SYT2 VPS36 VTA1 VPS37C VPS37D VPS37A STAM SNF8 VPS37B CHMP2B CHMP4C UBAP1 CHMP4B CHMP3 CHMP4A RDH5 CHMP6 VPS25 SH3GL3 STAM2 CHMP7 VPS28 CHMP5 ELK1 APC EP300 HGF MET RAP1A CTBP2 CREB1 TBXAS1 OGN ABCA12 ABCB6 MAPK1 MAPK3 ABCA4 ERLIN1 MAPK14 ERLIN2 CDK5 RANGAP1 RCC1 PGM1 ABCC6 DERL3 CDK5R1 ERLEC1 ERBB2IP HSP90AA1 CDC37 ERBB2 SLC25A5 SLC25A4 SLC25A6 BCAN VCAN NCAN ITGB1 BGN BSG CSPG5 CSPG4 CHST14 DCN OMD TALDO1 MMACHC BTD MMADHC IPO5 CAMK2B SDC4 GRSF1 CAMK2D SDC2 CAMK2A SDC3 NEU1 CAMK2G MUC20 EXT1 EXT2 SDC1 ACY1 KHK GAA AHCY SLC6A2 SLC6A5 CYP17A1 GCG HNRNPK DUSP16 CUX1 PHB DYNLL1 GALK1 AKAP9 DYNC1I2 GIF GALT SLC3A2 DYNC1H1 NEIL3 NEIL1 FGFR1OP CCNH ACTB HGS VPS33B NTHL1 RAB5A HIST1H2AE CORO1A HIST1H2AD HIST3H2BB RAB7A HIST1H2AC XRCC6 HIST1H2AB XRCC4 XRCC5 HIST1H2AJ GALE HIST2H3A HIST1H2BF HIST1H2BE HIST1H2BH HIST1H2BG HIST2H3D HIST1H2BB HIST1H2BA HIST2H3C WDR48 HIST1H2BD OGG1 HIST1H2BC HIST1H3J HIST1H3A HIST1H3F HIST1H3G HIST1H3H RPS4Y2 HIST1H3I RPS4Y1 HIST1H3B HIST1H3C GNS HIST1H3D HIST1H3E HIST1H4K HIST1H4L HIST1H4A CDK7 HIST1H4B CGA HIST1H4H HIST1H4I HIST1H4J HIST1H4C MNAT1 ST3GAL3 HIST1H4D HIST1H4E EZH2 TCN2 HIST1H4F HIST2H2AA3 GSK3B HIST2H2AA4 PAH NEDD4L HIST2H2AC LIG4 SIN3A MSH6 MSH3 TBP EED NCOR2 NCOR1 HIST2H2BE LRRFIP1 ABL1 KAT2B KAT2A GUCY2C HIST4H4 PAPSS2 PDZD3 PAPSS1 RPS15A HIST1H2BN HIST1H2BM HDAC2 HIST1H2BO HIST1H2BJ HDAC1 GSS HIST1H2BI HIST1H2BL HIST1H2BK HIST2H4A FDX1L HIST2H4B RBBP4 TPMT RPL10L RPL10A CYSLTR2 POLR2E POLR2F POLR2H RBBP7 POLR2K KERA POLR2L SUZ12 GTF2H1 SLC26A2 MAPK8 GTF2H2 GTF2H3 GTF2H4 GTF2H5 CLCN6 ERCC3 ERCC2 UGT1A1 APOA1 RPL13A EEF2 IKBKB GSK3A TTR CHUK MAP2K4 UGT1A4 BAD CASP9 IRAK4 FGFR2 MAP2K7 MYD88 NOS2 BCR MTRR RPS15 RPS14 RPS17 RPS16 RPS19 RPL18A RPL36AL RPS18 YWHAB RPS11 RPS10 RPS13 PSMD8 PSMD9 RPS12 PSMD6 SH3KBP1 SRC XPO1 PSMD7 PSMD4 PSMD5 CSK PSMD2 EPS15 CYP2U1 PPP2R5E PSMD3 AKT1 SH3GL1 PTGIR PSMD1 ADAM10 PTPN12 PPP2R5B SLC22A5 PPP2R5A SLC35D1 FGR PTPN11 PSMA5 RAC2 PSMA6 P2RX7 PSMA3 RHOG PSMA4 LHB PSMA1 P2RX4 PSMA2 PSME3 PSME4 PSME1 PSME2 SMAD2 UBA52 SMAD3 PSMD10 RPS26 PSMB11 PSMD12 RPS25 RPS28 PSMD11 PSMD14 RPS27 PSMD13 RPS29 PSMA7 PSMB10 RPS20 PSMA8 RPS21 RPS24 DVL2 RPS23 PSMB6 CD320 GBE1 PSMB7 RDH12 FZD7 PSMB4 PSMB5 NAPEPLD PSMB2 KLB SV2B SV2A CYP7B1 UBB PSMB3 SLC6A20 UBC PSMB1 GAB2 PSMF1 FGF19 FGFR4 RPS27A SHFM1 PSMB8 PSMB9 PSMC5 SLC12A3 PSMC6 PSMC3 RLBP1 PSMC4 SLC12A1 NT5E PSMC1 SLC12A6 PSMC2 OPN1MW2 NRG1 NRG2 SFPQ NRG3 NRG4 SV2C HDAC11 HEY1 HEY2 HDAC4 HDAC5 DLL1 HDAC9 HDAC6 HDAC7 DLL4 NEURL1B IDH1 HES5 JAG2 JAG1 MIB2 MIB1 HEYL NEURL1 BTRC CUL5 SKP1 BTK RBX1 ADCY9 GLP1R PRKAR1B PRKAR1A OPLAH SYNTHESIS OF DOLICHYL-PHOSPHATE%REACTOME%R-HSA-446199.1 Synthesis of Dolichyl-phosphate NUS1 SRD5A3 DOLK MVD DOLPP1 DHDDS ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON%REACTOME DATABASE ID RELEASE 72%936964 Activation of IRF3 IRF7 mediated by TBK1 IKK epsilon TBK1 PTPN11 UBB IRF7 UBC TANK RPS27A UBA52 IRF3 TICAM2 LY96 TICAM1 TRAF3 CD14 TLR4 IKBKE FREE FATTY ACID RECEPTORS%REACTOME%R-HSA-444209.1 Free fatty acid receptors FFAR1 GPR31 FFAR3 FFAR2 FFAR4 TP53 REGULATES TRANSCRIPTION OF DNA REPAIR GENES%REACTOME DATABASE ID RELEASE 72%6796648 TP53 Regulates Transcription of DNA Repair Genes TCEB3C TCEB3B POLR2E POLR2F POLR2H DDB2 RAD51D TCEB3CL2 POLR2K CCNH POLR2L TCEB3 GTF2H1 PMS2 TCEB2 GTF2H2 TCEB1 GTF2H3 TCEB3CL GTF2H4 ATF2 GTF2H5 ERCC3 ERCC2 MLH1 TCEA1 FOS MDC1 CCNK CCNT2 CCNT1 SSRP1 CHEK1 CTDP1 SUPT16H SUPT4H1 SUPT5H GTF2F1 GTF2F2 CDK7 POLR2A POLR2B POLR2C MSH2 POLR2D POLR2G NELFB FANCD2 MNAT1 NELFA NELFCD POLR2I POLR2J NELFE TP53 FANCI JUN FANCC CDK9 ATM CDK12 CDK13 ATR ELL BRCA1 TRUNCATIONS OF AMER1 DESTABILIZE THE DESTRUCTION COMPLEX%REACTOME%R-HSA-5467348.2 Truncations of AMER1 destabilize the destruction complex CSNK1A1 PPP2CA PPP2CB PPP2R5B PPP2R5A PPP2R5D GSK3B PPP2R5C PPP2R1B PPP2R1A AMER1 AXIN1 APC PPP2R5E YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION%REACTOME%R-HSA-2032785.3 YAP1- and WWTR1 (TAZ)-stimulated gene expression HIPK1 HIPK2 KAT2B YAP1 NPPA GATA4 TBX5 TEAD4 NKX2-5 CTGF WWTR1 TEAD1 TEAD2 TEAD3 TRANSPORT OF BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS%REACTOME%R-HSA-425366.3 Transport of bile salts and organic acids, metal ions and amine compounds SLC10A6 SLC14A2 SLC31A1 SLC22A3 SLC39A10 SLC22A5 SLC39A14 SLC39A6 SLC22A2 SLC39A5 SLC39A8 RHCG SLC39A7 SLC22A1 RHBG SLC39A2 SLC39A1 SLC39A4 SLC18A2 SLC39A3 RUNX1 RHAG SLC6A7 SLC16A1 SLC11A1 SLC6A2 SLC6A20 SLC16A8 SLC6A5 SLC40A1 SLC16A3 SLC6A9 SLC18A1 SLC6A13 HEPH SLC6A12 SLC6A11 SLC6A1 SLC30A7 SLC30A6 SLC30A8 SLC30A3 SLC6A3 SLC30A2 SLC30A5 SLC30A1 SLC11A2 SLC44A5 SLC44A3 SLC44A4 SLC44A1 SLC44A2 CP SLC6A19 SLC5A7 SLC6A18 SLC6A15 SLC6A14 SLC16A7 EMB SLC13A1 SLC13A2 BSG SLC13A3 SLC22A12 SLC13A4 SLC6A6 SLC2A13 SLC22A6 SLC47A2 SLC22A8 SLC47A1 SLC22A7 SLC22A11 SLC22A4 SLC41A2 RSC1A1 SLC5A11 SLC22A15 SLC41A1 SLC22A16 SLC30A10 SLC22A18 SLC5A3 SLC13A5 SLC14A1 B-WICH COMPLEX POSITIVELY REGULATES RRNA EXPRESSION%REACTOME%R-HSA-5250924.2 B-WICH complex positively regulates rRNA expression TAF1B TAF1C TAF1A TWISTNB POLR2E POLR2F POLR2H SF3B1 POLR2K POLR2L ACTB DEK HIST1H2AE HIST1H2AD HIST3H2BB HIST1H2AC HIST1H2AB MYBBP1A HIST1H2AJ CD3EAP ERCC6 HIST2H3A HIST1H2BF HIST1H2BE HIST1H2BH EP300 HIST1H2BG HIST2H3D HIST1H2BB HIST1H2BA HIST2H3C HIST1H2BD HIST1H2BC H2AFB1 HIST1H3J HIST1H3A HIST1H3F HIST1H3G HIST1H3H HIST1H3I HIST1H3B HIST1H3C HIST1H3D HIST1H3E H3F3B HIST1H4K HIST1H4L H3F3A SMARCA5 H2BFS HIST1H4A HIST1H4B HIST1H4H HIST1H4I HIST1H4J HIST1H4C HIST1H4D HIST1H4E HIST1H4F HIST2H2AA3 GSK3B HIST2H2AA4 HIST2H2AC ZNRD1 H2AFJ TBP H2AFZ H2AFX H2AFV BAZ1B HIST2H2BE KAT2B KAT2A POLR1A HIST4H4 POLR1B POLR1C POLR1E HIST1H2BN HIST1H2BM HIST1H2BO HIST1H2BJ HIST1H2BI HIST1H2BL HIST1H2BK DDX21 HIST2H4A TAF1D HIST2H4B REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN%REACTOME DATABASE ID RELEASE 72%170822 Regulation of Glucokinase by Glucokinase Regulatory Protein NUP85 TPR NUP88 NUP43 RAE1 RANBP2 GCKR NUP107 NUP155 NUP188 NUP153 GCK NUP62 NUP35 NUPL2 NDC1 NUP214 SEC13 NUP37 NUP133 NUP210 NUP93 NUP50 NUP54 POM121 NUP205 AAAS NUP160 VRNA SYNTHESIS%REACTOME DATABASE ID RELEASE 72%192814 vRNA Synthesis MHC CLASS II ANTIGEN PRESENTATION%REACTOME%R-HSA-2132295.3 MHC class II antigen presentation SEC24B DCTN4 KIF3A SEC24A DNM1 DNM3 CAPZA3 CD74 KIF26A CAPZA1 CAPZA2 CANX SEC24D ACTR10 SEC24C DYNC1LI1 DYNC1LI2 SAR1B SEC13 SH3GL2 KIF5B KIF5A KIF18A CTSV CTSD CTSS CTSL CTSK CTSB ACTR1B DYNLL2 CTSH KIF2A CTSC KIF2C LGMN KIF2B CTSA DYNC1I1 CENPE ACTR1A IFI30 AP1G1 HLA-DPA1 AP1S2 AP1B1 AP1S1 RACGAP1 DYNLL1 AP1S3 CLTC ARF1 CLTA AP1M2 AP2A1 AP1M1 AP2B1 AP2A2 AP2S1 AP2M1 DYNC1I2 HLA-DQB2 DCTN2 HLA-DQB1 DCTN3 HLA-DQA2 HLA-DQA1 DYNC1H1 HLA-DRB5 HLA-DRB4 HLA-DPB1 HLA-DRA HLA-DRB3 HLA-DRB1 RAB7A DNM2 OSBPL1A HLA-DMA SEC31A HLA-DMB KIFAP3 HLA-DOA HLA-DOB LAG3 KIF20A KLC1 KLC4 KLC3 KLC2 KIF3B KIF3C SPTBN2 RILP DCTN1 KIF4B KIF4A KIF11 SEC23A KIF15 CAPZB KIF23 KIF22 CTSO CTSF CTSE DCTN6 DCTN5 SYNAPTIC ADHESION-LIKE MOLECULES%REACTOME DATABASE ID RELEASE 72%8849932 Synaptic adhesion-like molecules GRIN2C GRIN2B GRIN2D GRIN1 LRFN3 GRIA3 PTPRD LRFN2 GRIA4 PTPRS DLG1 LRFN4 DLG4 DLG3 LRFN1 RTN3 PTPRF GRIN2A GRIA1 FLOT1 FLOT2 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX%REACTOME DATABASE ID RELEASE 72%3769402 Deactivation of the beta-catenin transactivating complex TLE4 AKT1 TLE3 TLE2 TLE1 KMT2D CTNNBIP1 PYGO1 MEN1 PYGO2 TCF7 YWHAZ TCF7L2 ASH2L BCL9L BCL9 CHD8 CBY1 UBA52 LEF1 SRY TCF7L1 APC SOX2 SOX3 SOX17 CTBP1 SOX9 SOX6 SOX7 SOX4 SOX13 UBB XIAP CTNNB1 UBC RBBP5 RPS27A BTRC HDAC1 AKT2 XPO1 POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME DATABASE ID RELEASE 72%622327 Postsynaptic nicotinic acetylcholine receptors CHRNA1 CHRNB2 CHRND CHRNB4 CHRNA3 CHRNB3 CHRNA2 CHRNA5 CHRNG CHRNA4 CHRNA7 CHRNE CHRNA6 CHRNA9 CARGO RECOGNITION FOR CLATHRIN-MEDIATED ENDOCYTOSIS%REACTOME%R-HSA-8856825.2 Cargo recognition for clathrin-mediated endocytosis STON1 STON2 SLC2A8 SGIP1 TACR1 EPN2 VAMP4 FCHO1 APOB FCHO2 REPS2 UBQLN1 REPS1 UBQLN2 NECAP2 SYT11 TFRC ARRB1 CD4 SH3GL2 VAMP8 VAMP7 TGOLN2 ADRB2 M6PR AVP IGF2R NEDD8 SLC18A3 VAMP3 NECAP1 PICALM CD3G TF FZD4 AVPR2 BTC EPGN TGFA AREG HBEGF WNT5A EREG CLTC CLTB CLTA AP2A1 AP2B1 AP2A2 AP2S1 AP2M1 SH3KBP1 EPS15 SYT1 SH3GL1 EPS15L1 EPN1 SYT2 SYT9 STAM VAMP2 ARRB2 ADRBK2 COPS7B UBA52 COPS7A HGS SH3GL3 STAM2 ADRBK1 DVL2 UBB UBC RPS27A CD3D GPS1 EGF CBL EGFR LDLRAP1 ITSN2 ITSN1 SCARB2 CHRM2 AGFG1 LRP2 AGTR1 COPS4 LDLR COPS3 CFTR COPS6 CLTCL1 COPS5 COPS2 KIAA0319 TOR1A COPS8 TOR1B SYT8 SNAP91 DAB2 AAK1 IL7R INTERLEUKIN-9 SIGNALING%REACTOME DATABASE ID RELEASE 72%8985947 Interleukin-9 signaling IL9R IL2RG STAT1 JAK1 JAK3 STAT3 STAT5A STAT5B IL9 DEFECTIVE SLCO1B1 CAUSES HYPERBILIRUBINEMIA, ROTOR TYPE (HBLRR)%REACTOME%R-HSA-5619110.2 Defective SLCO1B1 causes hyperbilirubinemia, Rotor type (HBLRR) SLCO1B1 ADRENALINE SIGNALLING THROUGH ALPHA-2 ADRENERGIC RECEPTOR%REACTOME DATABASE ID RELEASE 72%392023 Adrenaline signalling through Alpha-2 adrenergic receptor ADRA2C ADRA2A TNF RECEPTOR SUPERFAMILY (TNFSF) MEMBERS MEDIATING NON-CANONICAL NF-KB PATHWAY%REACTOME%R-HSA-5676594.1 TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway LTA LTB TNFSF11 CD40LG LTBR TNFRSF11A BIRC2 BIRC3 TNFSF14 TNFSF12 TRAF2 MAP3K14 TNFRSF13C TRAF3 TNFSF13B TNFRSF12A RPIA DEFICIENCY: FAILED CONVERSION OF R5P TO RU5P%REACTOME DATABASE ID RELEASE 72%5659996 RPIA deficiency: failed conversion of R5P to RU5P RPIA FRS-MEDIATED FGFR3 SIGNALING%REACTOME%R-HSA-5654706.3 FRS-mediated FGFR3 signaling HRAS FRS2 PTPN11 FRS3 FGF16 FGF18 NRAS FGF9 SOS1 FGF20 FGF1 FGF2 FGF23 FGF4 CYCLIN D ASSOCIATED EVENTS IN G1%REACTOME DATABASE ID RELEASE 72%69231 Cyclin D associated events in G1 PPP2CA CUL1 PPP2CB CDK7 LYN E2F2 E2F3 MNAT1 CKS1B CCND3 CCNH CCND2 JAK2 CDK6 RBL2 PTK6 UBA52 TFDP1 RBL1 CDK4 PPP2R1B TFDP2 PPP2R1A PPP2R2A E2F5 CDKN1C CDKN2A PPP2R3B ABL1 E2F1 E2F4 UBB CDKN1A CCND1 UBC CDKN1B RPS27A SKP1 RB1 CDKN2D SKP2 CDKN2B CDKN2C TRAIL SIGNALING%REACTOME%R-HSA-75158.3 TRAIL signaling TNFSF10 CASP10 TNFRSF10B TNFRSF10A CFLAR FADD TNFRSF10D CASP8 MISMATCH REPAIR (MMR) DIRECTED BY MSH2:MSH6 (MUTSALPHA)%REACTOME DATABASE ID RELEASE 72%5358565 Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) LIG1 EXO1 RPA1 MLH1 RPA2 POLD3 POLD4 MSH2 RPA3 POLD1 POLD2 PMS2 MSH6 PCNA ESR-MEDIATED SIGNALING%REACTOME DATABASE ID RELEASE 72%8939211 ESR-mediated signaling SMC3 DDX5 RAD21 STAG1 NRIP1 STAG2 SMC1A TNRC6C CARM1 GTF2F1 GTF2F2 TNRC6A POLR2A TNRC6B POLR2B POLR2C FOXO3 POLR2D UHMK1 POLR2G BCL2 POLR2I POLR2J HRAS BTC EPGN TGFA AREG NRAS HBEGF EREG MMP7 GPAM ESR2 STRN S1PR3 HIST1H2AE HIST1H2AD HIST3H2BB HIST1H2AC HIST1H2AB HIST1H2AJ HIST2H3A HIST1H2BF PPP5C HIST1H2BE HIST1H2BH HIST1H2BG GNAT3 HIST2H3D HIST1H2BB HIST1H2BA HIST2H3C HIST1H2BD HIST1H2BC H2AFB1 HIST1H3J HIST1H3A HIST1H3F HIST1H3G HIST1H3H HIST1H3I HIST1H3B HIST1H3C HIST1H3D HIST1H3E H3F3B MYC GNG10 HIST1H4K HIST1H4L H3F3A GNG12 H2BFS GNG11 HIST1H4A GNG13 TLE3 HIST1H4B HIST1H4H HIST1H4I GNB2 HIST1H4J FKBP5 HIST1H4C GNB1 GNB4 HIST1H4D HSP90AB1 HIST1H4E GNB3 HIST1H4F GNB5 HIST2H2AA3 YY1 HIST2H2AA4 EGF GNGT1 PIK3R1 HIST2H2AC GNGT2 EGFR PIK3CA H2AFJ TBP H2AFZ H2AFX ZDHHC7 H2AFV GNAI3 HIST2H2BE GNAI1 IGF1R KAT2B GNAI2 PPID CAV2 PRKCZ GNG3 HIST4H4 GNG2 GNG5 GNG4 GNG7 GNG8 HIST1H2BN HIST1H2BM HIST1H2BO HIST1H2BJ HDAC1 HIST1H2BI HIST1H2BL HIST1H2BK HIST2H4A HIST2H4B GTF2A1 GTF2A2 POLR2E POLR2F POLR2H POLR2K POLR2L KDM4B PIK3R3 KDM1A CTSD CCND1 KAT5 MMP2 MMP3 ESR1 KCTD6 NCOA1 JUN NCOA2 CREBBP NCOA3 MOV10 AGO3 AGO4 AGO1 AGO2 CDKN1B AKT2 FOXA1 AKT3 MYB PGR FKBP4 GATA3 XPO1 SRC POU2F1 MMP9 GREB1 CXCL12 AXIN1 CITED1 CHD1 NR5A2 PDPK1 AKT1 SPHK1 TFF1 KANK1 CXXC5 USF2 USF1 ZNF217 EBAG9 PRMT1 CBFB RUNX1 PIK3R2 ATF2 ELK1 NOS3 EP300 CAV1 PTK2 FOS KPNA2 CREB1 CCNT1 SP1 ZDHHC21 SRF MAPK1 MAPK3 JUND PTGES3 FOSB HSP90AA1 CDK9 MED1 SIGNALING BY FGFR4%REACTOME DATABASE ID RELEASE 72%5654743 Signaling by FGFR4 PPP2CA PPP2CB BRAF FRS2 PTPN11 SPRY2 FRS3 FGF16 FGF18 GAB1 PIK3R1 CBL UBA52 FGF6 PIK3CA FGF9 PLCG1 SOS1 PPP2R1A FGF20 FGF1 FGF2 FGF23 MKNK1 FGF4 HRAS KLB NRAS UBB UBC FGF19 FGFR4 RPS27A MAPK1 MAPK3 MAJOR PATHWAY OF RRNA PROCESSING IN THE NUCLEOLUS AND CYTOSOL%REACTOME%R-HSA-6791226.3 Major pathway of rRNA processing in the nucleolus and cytosol RPL26 WBSCR22 RPL29 RPL10L MPHOSPH10 RPS4X RPL10A RPL28 NOL11 NOL12 RPS3A RPL23A UTP14A UTP14C FAU RPL41 HEATR1 NOL9 NOL6 RPL3L PES1 BOP1 MPHOSPH6 RPP30 FBL RPP38 UTP11L RPP21 RPP25 EMG1 UTP20 RPP40 RCL1 RBM28 DDX49 DDX47 UTP15 DDX52 SENP3 UTP18 BMS1 RPL10 RPP14 RPL12 RPL13A RPL11 RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL27A RPS9 RPS7 RPS8 NHP2L1 RPS5 RPS6 RPSA SKIV2L2 RPS15 RPS14 RPS17 CSNK1D RPS16 CSNK1E RPS19 RPL18A RPL36AL RPS18 RPLP1 RPS11 RPS10 RPLP0 RPS13 RPS12 RPLP2 DIS3 RPL7A RPS27L UBA52 RPL37A RPS26 RPS25 RPS28 RPS27 RPL36A RPS29 RPS20 RPL35A RPS21 RPS24 RPS23 EXOSC7 EXOSC6 RRP1 EXOSC5 EXOSC4 RPL22L1 RRP9 WDR75 EXOSC9 EXOSC8 RRP7A PNO1 RPS4Y2 TBL3 EXOSC3 RPS4Y1 LAS1L RPS27A EXOSC2 XRN2 WDR46 EXOSC1 WDR43 RIOK2 RIOK1 WDR36 TEX10 DIEXF GNL3 PELP1 NIP7 NOC4L EXOSC10 RRP36 UTP6 UTP3 RIOK3 WDR18 WDR12 BYSL TSR1 RPL26L1 RPL4 RPL39L RPL5 RPL30 FTSJ3 RPL3 EBNA1BP2 RPL32 NCL RPL31 ISG20L2 RPL34 NOP14 RPL8 RPL9 WDR3 RPL6 RPL7 NOB1 RPL36 C1D RPL35 RPL38 RPL37 DCAF13 RPL39 NOP58 RPS15A KRR1 RPL21 LTV1 RPL23 FCF1 RPL22 NOP56 PWP2 IMP3 IMP4 CIRH1A DDX21 RPL24 PDCD11 RPL27 ERI1 DHX37 WNT5:FZD7-MEDIATED LEISHMANIA DAMPING%REACTOME DATABASE ID RELEASE 72%9673324 WNT5:FZD7-mediated leishmania damping NOXO1 DVL2 CYBA MAPK8 FZD7 DVL1 DVL3 NOX1 JUN RAC1 NOXA1 WNT5A CASPASE ACTIVATION VIA EXTRINSIC APOPTOTIC SIGNALLING PATHWAY%REACTOME DATABASE ID RELEASE 72%5357769 Caspase activation via extrinsic apoptotic signalling pathway CASP9 CASP8 TRADD TNFSF10 FAS TNFRSF10B FASLG CASP3 RIPK1 TNFRSF10A TRAF2 FADD UNC5A DAPK1 UNC5B DAPK2 DAPK3 APPL1 DCC MAGED1 TICAM2 LY96 TICAM1 CD14 TLR4 METABOLISM OF FOLATE AND PTERINES%REACTOME%R-HSA-196757.5 Metabolism of folate and pterines SHMT1 MTHFD2L ALDH1L1 MTHFD1L ALDH1L2 FOLR2 DHFRL1 SLC46A1 SLC19A1 SLC25A32 MTHFR MTHFS DHFR MTHFD1 MTHFD2 SHMT2 CHAPERONIN-MEDIATED PROTEIN FOLDING%REACTOME%R-HSA-390466.3 Chaperonin-mediated protein folding SPHK1 ACTB CSNK2A1 DCAF7 CCT6B TUBB6 CSNK2A2 GNAT2 TUBB3 GNAT3 TUBB1 FBXO4 LONP2 FBXO6 GNAT1 RGS9 RGS6 CSNK2B GAPDHS RGS7 FBXW4 FBXW5 FBXW10 FBXW7 FBXW9 TUBA4B FBXW2 TUBA4A XRN2 FKBP9 GNAZ GNG10 GNG12 GNG11 GNG13 GNAO1 CCT6A GNB2 CCNE2 GNB1 GNB4 CCNE1 PDCL GNB3 SKIV2L FBXL3 TP53 GNB5 FBXL5 TUBA8 WRAP53 GNGT1 TUBA1C TUBA1B GNGT2 TUBA1A KIF13A CCT3 CCT2 VBP1 TUBB2B TUBB2A TCP1 PFDN1 PFDN2 PFDN4 PFDN5 PFDN6 HDAC3 TUBAL3 USP11 GBA GNAI3 GNAI1 GNAI2 AP3M1 TUBA3E GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 CCT8 CCT7 CCT5 CCT4 NOP56 ARFGEF2 STAT3 TUBB4B TUBB4A RGS11 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER%REACTOME%R-HSA-6782210.1 Gap-filling DNA repair synthesis and ligation in TC-NER LIG1 POLK RPA1 POLE RPA2 POLD3 RFC1 POLD4 RPA3 AQR POLD1 POLR2E POLD2 POLR2F RFC5 POLR2H RFC3 RFC4 RFC2 ZNF830 POLR2K CCNH POLR2L UBA52 GTF2H1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 ERCC3 ERCC2 ERCC6 XRCC1 EP300 CUL4A POLE4 TCEA1 POLE2 PRPF19 UBB POLE3 ERCC8 UBC CUL4B RPS27A DDB1 USP7 CDK7 POLR2A POLR2B POLR2C POLR2D XAB2 POLR2G MNAT1 POLR2I POLR2J HMGN1 LIG3 PPIE UVSSA RBX1 ISY1 PCNA DEGRADATION OF GABA%REACTOME%R-HSA-916853.2 Degradation of GABA ALDH5A1 ABAT SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION%REACTOME DATABASE ID RELEASE 72%399955 SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion RND1 NRP1 FARP2 PIP5K1C RRAS PLXNA2 PLXNA1 PLXNA3 SEMA3A FES PLXNA4 FYN RAC1 TLN1 RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASES%REACTOME%R-HSA-388844.2 Receptor-type tyrosine-protein phosphatases LRRC4B PPFIA1 PPFIBP1 IL1RAPL2 IL1RAPL1 PPFIA4 PPFIBP2 PTPRD PPFIA3 PTPRS PPFIA2 SLITRK2 PTPRF SLITRK1 SLITRK4 SLITRK3 NTRK3 SLITRK6 SLITRK5 P2Y RECEPTORS%REACTOME%R-HSA-417957.2 P2Y receptors P2RY13 P2RY10 P2RY11 P2RY14 P2RY1 LPAR4 P2RY6 P2RY12 P2RY4 LPAR6 P2RY2 GPR17 AMPLIFICATION OF SIGNAL FROM THE KINETOCHORES%REACTOME%R-HSA-141424.2 Amplification of signal from the kinetochores PPP2R5B PPP2R5A PPP1CC CLASP1 DYNC1H1 NDE1 NUP107 PPP2R5C ERCC6L ZWILCH BUB1B CASC5 CDC20 PPP2R1B PPP2R1A KNTC1 DYNC1LI1 BIRC5 DYNC1LI2 CLIP1 RPS27 ZW10 MAD1L1 SEC13 CDCA8 NUP133 PMF1 SKA1 AURKB SKA2 DSN1 PPP2R5D RCC2 PLK1 NDC80 ZWINT KIF18A SGOL2 SGOL1 NUF2 SPDL1 NDEL1 NUDC DYNLL2 KIF2A INCENP KIF2C KIF2B ITGB3BP MIS12 CENPA NSL1 NUP160 CENPC PPP2CA BUB3 PPP2CB BUB1 NUP85 DYNC1I1 CLASP2 CENPT CENPU NUP43 CENPE APITD1 AHCTF1 CENPF RANGAP1 CENPH CENPI TAOK1 RANBP2 CENPK CENPL CENPM CENPN B9D2 CENPO CENPP CENPQ SPC24 MAD2L1 SPC25 NUP37 DYNLL1 CKAP5 MAPRE1 PAFAH1B1 XPO1 DYNC1I2 PPP2R5E DEFECTIVE SLC5A7 CAUSES DISTAL HEREDITARY MOTOR NEURONOPATHY 7A (HMN7A)%REACTOME DATABASE ID RELEASE 72%5658471 Defective SLC5A7 causes distal hereditary motor neuronopathy 7A (HMN7A) SLC5A7 SHC-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME DATABASE ID RELEASE 72%2428933 SHC-related events triggered by IGF1R IGF1 HRAS IGF2 IGF1R SOS1 NRAS SIGNALING BY FGFR2 IN DISEASE%REACTOME DATABASE ID RELEASE 72%5655253 Signaling by FGFR2 in disease GTF2F1 GTF2F2 POLR2A POLR2B POLR2C POLR2D POLR2G POLR2E FRS2 POLR2F FGF16 FGF7 POLR2H POLR2I POLR2J FGF18 POLR2K POLR2L GAB1 PIK3R1 FGFR2 FGF6 PIK3CA FGF9 PLCG1 SOS1 FGF20 FGF1 FGF2 FGF23 FGF3 FGF22 FGF10 FGF4 HRAS NRAS NCBP1 NCBP2 TNFR1-INDUCED NFKAPPAB SIGNALING PATHWAY%REACTOME%R-HSA-5357956.1 TNFR1-induced NFkappaB signaling pathway USP2 IKBKB SHARPIN CHUK GNB2L1 CYLD OTUD7B TRADD TNFAIP3 RIPK1 TRAF2 IKBKG TRAF1 TNFRSF1A BIRC2 TNF BIRC3 RNF31 XIAP USP4 USP21 RBCK1 TAB3 TAB2 TAB1 MAP3K7 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING%REACTOME%R-HSA-389958.2 Cooperation of Prefoldin and TriC CCT in actin and tubulin folding CCT6A TUBA8 TUBA1C TUBA1B TUBA1A ACTB CCT3 CCT2 VBP1 TUBB2B TUBB2A TCP1 PFDN1 PFDN2 PFDN4 PFDN5 PFDN6 CCT6B TUBAL3 TUBB6 TUBB3 TUBB1 TUBA3E CCT8 CCT7 CCT5 CCT4 TUBA4B TUBA4A TUBB4B TUBB4A DEFECTIVE SLC6A2 CAUSES ORTHOSTATIC INTOLERANCE (OI)%REACTOME DATABASE ID RELEASE 72%5619109 Defective SLC6A2 causes orthostatic intolerance (OI) SLC6A2 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA%REACTOME%R-HSA-159227.2 Transport of the SLBP independent Mature mRNA NUP85 TPR EIF4E NUP88 NUP43 RAE1 RANBP2 NUP107 NUP155 NUP188 NUP153 NUP62 NUP35 NUPL2 NXF1 NDC1 NUP214 SEC13 NUP37 NUP133 NUP210 NUP93 NUP50 NUP54 POM121 NUP205 NCBP1 NCBP2 AAAS NUP160 HORMONE LIGAND-BINDING RECEPTORS%REACTOME%R-HSA-375281.1 Hormone ligand-binding receptors GNRH2 GNRH1 GPHB5 CGA LHCGR GNRHR FSHR GPHA2 FSHB TSHR LHB TSHB CLASS C 3 (METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS)%REACTOME%R-HSA-420499.1 Class C 3 (Metabotropic glutamate pheromone receptors) GRM7 GRM6 GRM8 TAS2R1 TAS2R20 TAS2R3 TAS2R5 TAS2R10 TAS2R4 TAS2R13 TAS1R2 TAS2R14 TAS1R1 TAS2R16 TAS1R3 TAS2R19 TAS2R40 TAS2R41 TAS2R42 TAS2R43 TAS2R46 GRM1 GRM5 TAS2R30 TAS2R31 TAS2R38 TAS2R39 GABBR2 GABBR1 TAS2R60 TAS2R50 GPRC6A CASR TAS2R7 GRM3 TAS2R9 TAS2R8 GRM2 GRM4 DEFECTIVE DPM1 CAUSES DPM1-CDG (CDG-1E)%REACTOME DATABASE ID RELEASE 72%4717374 Defective DPM1 causes DPM1-CDG (CDG-1e) DPM1 DPM2 DPM3 INHIBITION OF MEMBRANE REPAIR%REACTOME DATABASE ID RELEASE 72%9635644 Inhibition of membrane repair HGS CELL CYCLE, MITOTIC%REACTOME%R-HSA-69278.4 Cell Cycle, Mitotic CUL1 RAB1B PRKAR2B YWHAG RFC5 RFC3 RFC4 RFC2 PPP2R5C ERCC6L OFD1 ZWILCH RBL2 BUB1B CCNA2 CASC5 CCNA1 SMC3 TFDP1 CDC20 RBL1 TFDP2 PTTG1 KNTC1 DYNC1LI1 BIRC5 DYNC1LI2 CLIP1 ZW10 MAD1L1 CDCA5 CSNK2A1 CDCA8 PDS5B PDS5A CSNK2A2 PMF1 SKA1 AURKB SKA2 AURKA DSN1 RAD21 E2F1 RCC2 NDC80 E2F4 ZWINT STAG1 KIF18A CSNK2B STAG2 SGOL2 SGOL1 NUF2 WAPAL SPDL1 NDEL1 NUDC SMC1A DYNLL2 ESPL1 KIF2A INCENP KIF2C KIF2B ITGB3BP MIS12 CENPA NSL1 CENPC BUB3 BUB1 DYNC1I1 CLASP2 CENPT FZR1 CENPU E2F2 CENPE E2F3 CENPF GINS1 CENPH GINS2 CENPI GINS3 TAOK1 GINS4 CENPK CENPL CHMP2A CENPM CENPN B9D2 CENPO CENPP CENPQ SPC24 MAD2L1 SPC25 LPIN1 LPIN2 NEK9 LPIN3 NEK6 NEK7 MAU2 NIPBL TUBB6 ANAPC15 ANAPC16 TUBB3 ANAPC7 TUBB1 UBE2C PLK1 UBE2E1 UBE2D1 ANAPC10 ANAPC11 CCNB1 CDC23 CDC26 CDC27 CDC16 CDK1 ANAPC4 TUBA4B ANAPC5 ANAPC1 TUBA4A ANAPC2 KPNB1 RB1 GMNN MYC CDKN2D FBXO5 CDKN2B SKP2 CDKN2C CDC25A MAX ORC5 ORC4 ORC6 ORC1 ORC3 ORC2 CDT1 CDC7 CDC6 HSP90AB1 POLA1 POLA2 LIN54 MCM7 MCM8 MCM10 TUBA8 CKS1B LIN52 DBF4 TUBA1C MCM3 TUBA1B MCM4 MCM5 TUBA1A MCM6 MCM2 PRIM2 LIN37 PRIM1 TUBB2B LIN9 TUBB2A CDC45 E2F5 E2F6 CABLES1 PPP2R3B WEE1 RPA4 TUBAL3 TUBA3E TUBB4B TUBB4A FEN1 PCNA LIG1 RPA1 RPA2 POLD3 POLD4 RPA3 POLD1 POLD2 DNA2 NUP107 NUP188 JAK2 BANF1 PPP2R1B PPP2R1A NUP62 PRKACA NDC1 NUP214 SEC13 NUP133 NUP210 PPP2R5D NUP93 NUP50 NUP54 CCND1 ANKLE2 DHFR EMD VRK1 LEMD3 SIRT2 POM121 NUP205 AAAS NUP160 PPP2CA PPP2CB NUP85 TPR NUP88 NUP43 RAE1 RANBP2 NUP155 NUP153 CDK4 NUP35 NUPL2 NUP37 AKT2 AKT3 SUMO1 PRKCB VPS4A CCND3 CCND2 CDK6 CHMP2B CHMP4C CHMP4B CHMP3 CHMP4A CHMP6 CHMP7 EP300 MAPK1 AHCTF1 RANGAP1 RCC1 PKMYT1 FOXM1 RAN MYBL2 TUBB8P12 TUBB8 HSP90AA1 SPAST LEMD2 CC2D1B LYN CDC25B LMNB1 GOLGA2 CEP57 CETN2 CEP164 CCP110 PPP1CB ACTR1A PCM1 CNTRL CEP250 NEK2 NINL CEP290 RAB8A CDK5RAP2 CEP135 BORA PPP1R12A FBXW11 TUBB CEP131 HAUS4 HAUS3 HAUS6 CSNK1D HAUS5 UBE2I CSNK1E TUBG1 DYNLL1 CKAP5 HAUS2 HAUS1 AKAP9 CEP63 MAPRE1 AJUBA SFI1 OPTN PAFAH1B1 SDCCAG8 DYNC1I2 DCTN2 SSNA1 DCTN3 CCNB2 HAUS8 HAUS7 CEP70 CEP72 CEP192 PCNT CEP76 CLASP1 CEP78 PLK4 DYNC1H1 ODF2 CEP152 NDE1 NEDD1 FGFR1OP CEP41 CCNH RRM2 SMC4 SMC2 HIST1H2AE EML4 HIST1H2AD HIST3H2BB NCAPG ARPP19 HIST1H2AC NCAPH HIST1H2AB NCAPH2 NCAPG2 HIST1H2AJ ENSA NCAPD2 NCAPD3 HIST2H3A CTDNEP1 HIST1H2BF NUMA1 HIST1H2BE CNEP1R1 HIST1H2BH HIST1H2BG MASTL HIST2H3D MCPH1 HIST1H2BB PPP2R2D HIST1H2BA HIST2H3C HIST1H2BD HIST1H2BC H2AFB1 HIST1H3J HIST1H3A HIST1H3F HIST1H3G HIST1H3H HIST1H3I HIST1H3B HIST1H3C HIST1H3D HIST1H3E H3F3B HIST1H4K HIST1H4L H3F3A H2BFS HIST1H4A CDK7 HIST1H4B HIST1H4H HIST1H4I HIST1H4J APITD1 HIST1H4C MNAT1 HIST1H4D HIST1H4E HIST1H4F HIST2H2AA3 GSK3B HIST2H2AA4 HIST2H2AC H2AFJ TK1 H2AFZ H2AFX H2AFV HIST2H2BE ABL1 USO1 HIST4H4 IST1 HIST1H2BN HIST1H2BM HIST1H2BO HIST1H2BJ HDAC1 HIST1H2BI HIST1H2BL HIST1H2BK HIST2H4A HIST2H4B RBBP4 POLE GTSE1 FKBPL RFC1 PPP1CC GORASP1 RAB2A GORASP2 BLZF1 HMMR ESCO1 ESCO2 POLE4 POLE2 LBR HIST3H3 POLE3 TP53 TPX2 PPME1 PHLDA1 TUBGCP2 TUBGCP5 TUBGCP6 TUBGCP3 TUBGCP4 FBXL7 TUBG2 MZT2B CDKN1A MZT2A NME7 LCMT1 CDKN1B CDK11A FBXL18 SETD8 MZT1 PSMD8 PSMD9 PSMD6 XPO1 PSMD7 PSMD4 PSMD5 PSMD2 PPP2R5E PSMD3 AKT1 PSMD1 TNPO1 PPP2R5B PPP2R5A PRKCA PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 UBA52 PSMD10 PSMB11 PSMD12 SET PPP2R2A PSMD11 RPS27 PSMD14 DYRK1A TOP2A PSMD13 CDKN1C CDKN2A PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 CENPJ PSMB5 PSMB2 UBB PSMB3 UBC PSMB1 PSMF1 RPS27A CDC14A SHFM1 TYMS PSMB8 PSMB9 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 CDC25C CCNE2 CCNE1 KIF20A PTK6 CDK2 KIF23 BTRC SKP1 YWHAE RBX1 RAB1A INTERLEUKIN-3, INTERLEUKIN-5 AND GM-CSF SIGNALING%REACTOME%R-HSA-512988.5 Interleukin-3, Interleukin-5 and GM-CSF signaling RAPGEF1 IL3RA IL2RB LYN VAV1 INPPL1 YES1 PTPN11 YWHAZ CRK PIK3CD INPP5D SHC1 PTPN6 JAK2 PIK3R1 CBL PIK3R2 PIK3CA SYK SOS1 TEC PRKACA FYN HCK PIK3R3 BLNK CRKL STAT5A STAT5B CSF2RB CSF2 CSF2RA GAB2 IL2 PIK3CB IL2RG JAK1 JAK3 IL2RA IL5RA IL3 IL5 REGULATION OF CORTICAL DENDRITE BRANCHING%REACTOME DATABASE ID RELEASE 72%8985801 Regulation of cortical dendrite branching ROBO2 SLIT1 ROBO1 NCK2 PLATELET ADHESION TO EXPOSED COLLAGEN%REACTOME DATABASE ID RELEASE 72%75892 Platelet Adhesion to exposed collagen LYN VWF GP1BB ITGA10 GP1BA GP5 ITGB1 GP9 ITGA1 GP6 FCER1G FYN ITGA2 REGULATION OF SIGNALING BY NODAL%REACTOME%R-HSA-1433617.1 Regulation of signaling by NODAL ACVR1C DAND5 NODAL CER1 CFC1 ACVR1B ACVR2B ACVR2A LEFTY1 TDGF1 LEFTY2 TRANSCRIPTIONAL REGULATION OF GRANULOPOIESIS%REACTOME DATABASE ID RELEASE 72%9616222 Transcriptional regulation of granulopoiesis RARA CBFB RUNX1 CSF3R TFDP1 DEK HIST1H2AE TFDP2 HIST1H2AD HIST3H2BB HIST1H2AC HIST1H2AB HIST1H2AJ SPI1 HIST2H3A HIST1H2BF HIST1H2BE HIST1H2BH GATA2 EP300 HIST1H2BG HIST2H3D HIST1H2BB E2F1 HIST1H2BA TAL1 HIST2H3C HIST1H2BD HIST1H2BC H2AFB1 HIST1H3J HIST1H3A HIST1H3F HIST1H3G CREB1 HIST1H3H HIST1H3I HIST1H3B HIST1H3C HIST1H3D HIST1H3E GFI1 H3F3B MYC CEBPA HIST1H4K CEBPE HIST1H4L FLI1 H3F3A KLF5 H2BFS HIST1H4A HIST1H4B HIST1H4H HIST1H4I HIST1H4J KMT2A HIST1H4C HIST1H4D HIST1H4E HIST1H4F HIST2H2AA3 HIST2H2AA4 HIST2H2AC LEF1 CDK4 H2AFJ CEBPB H2AFZ H2AFX H2AFV HIST2H2BE RXRA HIST4H4 CDK2 CDKN1A HIST1H2BN HIST1H2BM IL6R HIST1H2BO HIST1H2BJ STAT3 MYB HIST1H2BI HIST1H2BL HIST1H2BK HIST2H4A HIST2H4B SUMOYLATION%REACTOME DATABASE ID RELEASE 72%2990846 SUMOylation RPA1 RARA TDG WRN NUP107 NUP188 SUZ12 SMC3 EID3 BIRC5 NUP62 NDC1 NUP214 RELA CDCA8 SEC13 DDX5 NUP133 NUP210 ZNF131 AURKB RAD52 ZNF350 AURKA UHRF2 CTBP1 RAD21 PARK7 BMI1 NUP93 RNF2 TRIM28 STAG1 NUP50 NRIP1 CBX8 STAG2 DDX17 NUP54 TFAP2B PHC2 MDC1 MITF PHC1 RING1 FOXL2 HIC1 CBX4 CBX2 SP3 RWDD3 NSMCE4A PCGF2 SMC1A TOP1 MBD1 MKL1 PML SAFB PHC3 INCENP POM121 NSMCE2 NUP205 NSMCE1 DAXX AAAS NUP160 ZBED1 NUP85 TPR NUP88 NUP43 HNRNPK HNRNPC RAE1 RANBP2 TP53 ESR1 NUP155 NFKB2 NUP153 SATB2 CETN2 NCOA1 NUP35 NUPL2 NCOA2 PPARGC1A CREBBP NUP37 TFAP2C SMC5 PPARG RXRA SMC6 PPARA UBE2I PGR SENP5 SENP2 BRCA1 SENP1 SP100 NDNL2 SUMO1 SUMO3 SUMO2 HERC2 UBA2 ING2 SAE1 L3MBTL2 CBX5 PIAS4 XPC TP53BP1 NFKBIA XRCC4 IKBKG TOP2A IKBKE NPM1 TOPORS CDKN2A TRIM27 VDR VHL AR EP300 HIPK2 SATB1 RORA DNMT1 PARP1 RNF168 HIST1H4K HIST1H4L HIST1H4A NR3C1 HIST1H4B HIST1H4H HIST1H4I HIST1H4J HIST1H4C THRB HIST1H4D TOP2B RANGAP1 NR2C1 NR4A2 HIST1H4E NR5A1 HIST1H4F CHD3 PIAS3 SIN3A PIAS1 DNMT3B DNMT3A NCOR2 HDAC4 HDAC7 HIST4H4 NOP58 MDM2 HDAC2 NR1H2 HDAC1 NR3C2 HIST2H4A BLM HIST2H4B PCNA MTA1 BINDING AND ENTRY OF HIV VIRION%REACTOME%R-HSA-173107.1 Binding and entry of HIV virion CD4 CCR5 CXCR4 PPIA DEFECTIVE SLC24A5 CAUSES OCULOCUTANEOUS ALBINISM 6 (OCA6)%REACTOME%R-HSA-5619036.1 Defective SLC24A5 causes oculocutaneous albinism 6 (OCA6) SLC24A5 G2 PHASE%REACTOME DATABASE ID RELEASE 72%68911 G2 Phase CCNA2 CCNA1 E2F1 E2F3 CDK2 SEROTONIN AND MELATONIN BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 72%209931 Serotonin and melatonin biosynthesis TPH2 DDC AANAT TPH1 ASMT NOSIP MEDIATED ENOS TRAFFICKING%REACTOME DATABASE ID RELEASE 72%203754 NOSIP mediated eNOS trafficking NOS3 NOSIP DEFECTIVE ALG1 CAUSES ALG1-CDG (CDG-1K)%REACTOME DATABASE ID RELEASE 72%4549380 Defective ALG1 causes ALG1-CDG (CDG-1k) ALG1 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS%REACTOME%R-HSA-674695.3 RNA Polymerase II Pre-transcription Events GTF2B GTF2A1 TCEB3C GTF2A2 TCEB3B GTF2E1 GTF2E2 POLR2E POLR2F POLR2H TCEB3CL2 POLR2K CCNH POLR2L TCEB3 GTF2H1 TCEB2 GTF2H2 TCEB1 GTF2H3 TCEB3CL GTF2H4 TAF9B GTF2H5 ERCC3 ERCC2 TAF9 TAF1L TCEA1 TAF15 TAF12 TAF13 CCNK TAF10 CCNT2 TAF11 CCNT1 SSRP1 WDR61 CTDP1 TAF7 NCBP1 LEO1 TAF6 SUPT16H NCBP2 TAF5 SUPT4H1 TAF4 SUPT5H TAF3 GTF2F1 TAF2 GTF2F2 CDK7 POLR2A POLR2B TAF1 POLR2C POLR2D POLR2G NELFB MNAT1 NELFA NELFCD POLR2I POLR2J NELFE AK6 CDC73 TBP CDK9 TAF4B ELL AFF4 CTR9 MLLT1 RTF1 MLLT3 SUPT6H IWS1 EAF1 EAF2 TAF7L PAF1 DEFECTIVE OGG1 SUBSTRATE PROCESSING%REACTOME%R-HSA-9656256.1 Defective OGG1 Substrate Processing OGG1 DEFECTIVE GGT1 CAUSES GLUTATHIONURIA (GLUTH)%REACTOME DATABASE ID RELEASE 72%9035968 Defective GGT1 causes Glutathionuria (GLUTH) GGT1 ERYTHROPOIETIN ACTIVATES PHOSPHOINOSITIDE-3-KINASE (PI3K)%REACTOME DATABASE ID RELEASE 72%9027276 Erythropoietin activates Phosphoinositide-3-kinase (PI3K) EPO GAB1 JAK2 PIK3R1 LYN PIK3CB PIK3CA PIK3CD PIK3CG PIK3R5 IRS2 EPOR DEFECTIVE SLC7A9 CAUSES CYSTINURIA (CSNU)%REACTOME DATABASE ID RELEASE 72%5660883 Defective SLC7A9 causes cystinuria (CSNU) SLC7A9 SLC3A1 ACTIVATION OF SMO%REACTOME%R-HSA-5635838.1 Activation of SMO CSNK1A1 GAS1 ADRBK1 GAS8 EVC2 KIF3A PTCH1 ARRB2 CDON SHH DHH EFCAB7 IHH BOC IQCE SMO ARRB1 EVC DEFECTIVE SLC33A1 CAUSES SPASTIC PARAPLEGIA 42 (SPG42)%REACTOME%R-HSA-5619061.1 Defective SLC33A1 causes spastic paraplegia 42 (SPG42) SLC33A1 RUNX3 REGULATES YAP1-MEDIATED TRANSCRIPTION%REACTOME%R-HSA-8951671.1 RUNX3 regulates YAP1-mediated transcription RUNX3 TEAD4 YAP1 CTGF WWTR1 TEAD1 TEAD2 TEAD3 SIGNALING BY NOTCH2%REACTOME DATABASE ID RELEASE 72%1980145 Signaling by NOTCH2 MAML2 NCSTN MAML1 ADAM10 APH1B GZMB FCER2 RBPJ HES1 CNTN1 MDK MAML3 MAMLD1 UBA52 PSENEN NOTCH2 EP300 DLL1 DLL4 NEURL1B HES5 UBB JAG2 JAG1 MIB2 MIB1 UBC NEURL1 CREB1 RPS27A PSEN2 PSEN1 APH1A ELECTRIC TRANSMISSION ACROSS GAP JUNCTIONS%REACTOME DATABASE ID RELEASE 72%112303 Electric Transmission Across Gap Junctions PANX2 GJC1 GJD2 PANX1 GJA10 ACYL CHAIN REMODELING OF CL%REACTOME DATABASE ID RELEASE 72%1482798 Acyl chain remodeling of CL PLA2G4A HADHB HADHA TAZ LCLAT1 PLA2G6 ANTI-INFLAMMATORY RESPONSE FAVOURING LEISHMANIA PARASITE INFECTION%REACTOME%R-HSA-9662851.1 Anti-inflammatory response favouring Leishmania parasite infection PRKAR2B PRKAR2A CYSLTR2 HTR6 PLCG2 HTR7 GNAS HTR4 ADCY4 VIPR1 ADCY3 VIPR2 PRKACG SCT ADCY2 RXFP1 PRKACA ADCY1 RXFP2 PRKACB ADCY8 IGHG4 ADCY7 CYSLTR1 ADCY6 GPR176 ADCY5 IGHG1 IGHG2 IGKV1-12 PTGDR LHCGR TAAR8 TAAR9 TAAR6 TAAR5 TAAR2 TAAR1 ADCYAP1 ADAM17 IGKV2D-28 IGKV4-1 IAPP ADCYAP1R1 CALCA CALCRL CALCB IGKV2D-30 GIPR GPR83 ADRB1 GPR84 ADRB2 CRHR1 CRHR2 GHRHR TSHB GCG MC2R CALCR HRH2 DRD1 IGKV3-11 DRD5 LYN CD163 GPR15 AVP YES1 IL6 MC1R RLN2 RLN3 GPR27 GPR25 GPR20 ADM CD3G PTH1R MC4R FCGR3A IGKV2-28 INSL3 IL10 GPR39 SYK FSHB GPR32 AVPR2 GLP2R POMC RHBDF2 IGKV3D-20 GPBAR1 PTH2R GIP MC3R PLK2 HCK ADORA2A ADRB3 ADORA2B FSHR CRH MYH9 NPSR1 PTGER4 RAMP2 AHCYL1 RAMP3 GPR45 PTH PTGER2 PRKX PTH2 PTHLH NPS GPR150 FCGR1A GPHA2 P2RY11 IGKV5-2 SCTR TSHR FCGR2A FURIN GHRH ADM2 MC5R VIP RAMP1 PTGIR GPHB5 GGT1 FGR DPEP2 DPEP1 LHB DPEP3 ITPR1 ITPR2 ITPR3 FYN GGT5 GNAT3 CREB1 GNAZ GNG10 GNG12 GNG11 GNG13 CGA GNB2 MAPK14 GNB1 GNB4 GNB3 GNB5 GNGT1 GNGT2 PLCG1 GNAI3 GNAI1 GNAI2 GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 ADCY9 GLP1R PRKAR1B PRKAR1A ACTIVATED POINT MUTANTS OF FGFR2%REACTOME DATABASE ID RELEASE 72%2033519 Activated point mutants of FGFR2 FGF16 FGF7 FGF18 FGFR2 FGF6 FGF9 FGF20 FGF1 FGF2 FGF23 FGF3 FGF22 FGF10 FGF4 DEFECTIVE PMM2 CAUSES PMM2-CDG (CDG-1A)%REACTOME DATABASE ID RELEASE 72%4043911 Defective PMM2 causes PMM2-CDG (CDG-1a) PMM2 GLYCOGEN METABOLISM%REACTOME%R-HSA-8982491.1 Glycogen metabolism AGL PGM2 PGM1 PYGB UBA52 PHKA1 PHKA2 PYGM UGP2 PYGL GYG2 GYG1 PHKG1 PHKB PHKG2 PPP1R3C GBE1 GYS2 GYS1 PGM2L1 GAA UBB UBC RPS27A EPM2A NHLRC1 ABNORMAL CONVERSION OF 2-OXOGLUTARATE TO 2-HYDROXYGLUTARATE%REACTOME DATABASE ID RELEASE 72%2978092 Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate IDH1 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES%REACTOME%R-HSA-380270.2 Recruitment of mitotic centrosome proteins and complexes HAUS7 CEP70 PRKAR2B CEP72 CEP192 PCNT CEP76 YWHAG CLASP1 CEP78 PLK4 DYNC1H1 ODF2 CEP152 NDE1 NEDD1 FGFR1OP CEP41 OFD1 PPP2R1A PRKACA PLK1 CENPJ CDK1 TUBA4A CEP57 CETN2 TUBA1A CEP164 CCP110 ACTR1A PCM1 HSP90AA1 CNTRL CEP250 NEK2 NINL CEP290 CDK5RAP2 CEP135 TUBB CEP131 HAUS4 TUBGCP2 HAUS3 TUBGCP5 HAUS6 TUBGCP6 CSNK1D TUBGCP3 HAUS5 TUBGCP4 CSNK1E TUBG2 TUBG1 DYNLL1 MZT2B CKAP5 MZT2A HAUS2 NME7 HAUS1 AKAP9 CDK11A CEP63 MAPRE1 MZT1 YWHAE SFI1 TUBB4B PAFAH1B1 TUBB4A SDCCAG8 DYNC1I2 DCTN2 SSNA1 DCTN3 HAUS8 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME DATABASE ID RELEASE 72%176814 Activation of APC C and APC C:Cdc20 mediated degradation of mitotic proteins PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 BUB1B CCNA2 CCNA1 UBA52 CDC20 PSMD10 PTTG1 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 ANAPC15 ANAPC16 PSMB6 ANAPC7 PSMB7 UBE2C PLK1 UBE2E1 PSMB4 UBE2D1 ANAPC10 PSMB5 ANAPC11 PSMB2 CCNB1 UBB CDC23 PSMB3 CDC26 CDC27 UBC CDC16 PSMB1 CDK1 ANAPC4 PSMF1 ANAPC5 ANAPC1 RPS27A ANAPC2 SHFM1 PSMB8 PSMB9 PSMC5 PSMC6 PSMC3 PSMC4 BUB3 PSMC1 PSMC2 MAD2L1 NEK2 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 CELL RECRUITMENT (PRO-INFLAMMATORY RESPONSE)%REACTOME%R-HSA-9664424.1 Cell recruitment (pro-inflammatory response) CASP1 SUGT1 HSP90AB1 C3AR1 P2RX7 TXNIP MEFV P2RX4 CTSG IL18 IL1A TXN IL1B NFKB1 NFKB2 C3 PYCARD ENTPD1 NLRP3 ENTPD5 RELA NT5E PSTPIP1 STRIATED MUSCLE CONTRACTION%REACTOME%R-HSA-390522.1 Striated Muscle Contraction TNNI3 DMD TPM4 TPM3 TPM2 ACTN2 TPM1 TTN TNNI1 TNNI2 TMOD1 MYBPC3 MYBPC1 MYBPC2 ACTN3 TMOD4 TMOD3 TNNC1 TMOD2 TNNC2 NEB MYL4 DES MYH3 TNNT1 MYL1 TNNT2 MYL2 TNNT3 MYL3 MYH8 TCAP VIM MYH6 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION%REACTOME DATABASE ID RELEASE 72%888590 GABA synthesis, release, reuptake and degradation CPLX1 GAD1 RIMS1 GAD2 DNAJC5 SLC32A1 STX1A ALDH5A1 ABAT VAMP2 SLC6A13 SLC6A12 SLC6A11 SLC6A1 HSPA8 SNAP25 RAB3A SYT1 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY%REACTOME%R-HSA-3359457.1 Defective GIF causes intrinsic factor deficiency GIF FGFR3 LIGAND BINDING AND ACTIVATION%REACTOME%R-HSA-190239.1 FGFR3 ligand binding and activation FGF9 FGF20 FGF16 FGF1 FGF2 FGF18 FGF23 GALNT3 FGF4 INACTIVATION OF CDC42 AND RAC1%REACTOME%R-HSA-428543.2 Inactivation of CDC42 and RAC1 SRGAP1 ARHGAP39 CDC42 SLIT2 ROBO1 RAC1 SRGAP3 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION%REACTOME%R-HSA-2029482.2 Regulation of actin dynamics for phagocytic cup formation VAV1 WIPF1 CFL1 VAV2 WIPF2 WIPF3 ELMO1 NF2 ELMO2 CRK DOCK1 LIMK1 ARPC1B ARPC1A WAS MYO9B ACTG1 ACTB NCKIPSD CDC42 PAK1 ARPC4 NCKAP1L ARPC5 ARPC2 IGHG4 WASF1 ARPC3 WASF2 IGHG1 ACTR3 IGHG2 ACTR2 WASF3 IGKV1-12 MYH2 MYO10 MYO1C BAIAP2 PTK2 ABI2 ABI1 IGKV2D-28 IGKV4-1 IGKV2D-30 MAPK1 MAPK3 IGKV3-11 HSP90AB1 MYO5A WASL CD3G FCGR3A IGKV2-28 SYK HSP90AA1 IGKV3D-20 ABL1 MYH9 CYFIP2 CYFIP1 NCKAP1 BRK1 FCGR1A BTK IGKV5-2 FCGR2A RAC1 NCK1 VAV3 ACTIVATED NTRK2 SIGNALS THROUGH PI3K%REACTOME%R-HSA-9028335.1 Activated NTRK2 signals through PI3K GAB1 PIK3R1 PIK3CA NTRK2 BDNF NTF4 DEFECTIVE GALK1 CAN CAUSE GALACTOSEMIA II (GALCT2)%REACTOME DATABASE ID RELEASE 72%5609976 Defective GALK1 can cause Galactosemia II (GALCT2) GALK1 APC-CDC20 MEDIATED DEGRADATION OF NEK2A%REACTOME%R-HSA-179409.2 APC-Cdc20 mediated degradation of Nek2A BUB3 BUB1B UBA52 MAD2L1 CDC20 NEK2 ANAPC15 ANAPC16 ANAPC7 UBE2C UBE2E1 UBE2D1 ANAPC10 ANAPC11 UBB CDC23 CDC26 CDC27 UBC CDC16 ANAPC4 ANAPC5 RPS27A ANAPC1 ANAPC2 FATTY ACID METABOLISM%REACTOME DATABASE ID RELEASE 72%8978868 Fatty acid metabolism ACOT6 ACOT4 OLAH GPX2 SCD5 SCP2 DECR2 SLC25A1 CYP1A2 CYP1A1 ACBD5 PRKAA2 ACBD4 EPHX2 CROT ACSF3 LTA4H HSD17B3 HSD17B4 CYP4F2 HSD17B8 CYP4F3 FAAH2 CYP4F8 FASN ABCD1 CYP8B1 PRKAB2 NUDT7 ABCC1 PTGIS HACD1 EHHADH TECR ALOXE3 PON3 HPGD HACD3 PON2 HACD2 PON1 LTC4S PCTP HACD4 SCD ALOX5AP HAO2 PLA2G4A HADHB HADHA MORC2 ACSBG1 RXRA CYP2C9 CYP2C8 ACSBG2 PPARD CYP4F22 CYP4A22 AKR1C3 ACOXL PRKAG2 CPT1A CPT1B TECRL ELOVL1 CYP4F11 CYP2U1 ELOVL4 CRAT ELOVL5 CYP4A11 ELOVL2 ELOVL3 ACOX2 ELOVL6 ACOX3 FADS2 GGT1 SLC22A5 ELOVL7 PTGR1 ACAA1 PTGR2 NUDT19 DPEP2 DPEP1 FADS1 DPEP3 GPX1 GPX4 ACACA PTGS2 PTGS1 ACLY SLC27A3 SLC27A2 GGT5 CYP2C19 ACADVL ECHS1 ACAA2 ACSM3 ECI1 CBR1 FAAH ACSM6 DBI PECR MCEE ACADL THEM5 THEM4 HPGDS ACADM ACAD11 HADH CPT2 PTGDS ACADS ACAD10 MAPKAPK2 DECR1 ACSL1 ACBD7 ACBD6 ACOT9 MECR ACSL6 TBXAS1 ACOT7 ACSL5 ACSL4 MMAA ACOT11 ACSL3 ACOT12 ACOT13 HACL1 MUT MCAT ACSF2 PCCA PTGES PCCB NDUFAB1 ACOT2 ACOT1 CBR4 PTGES2 PTGES3 PPT1 PPT2 THRSP SLC25A17 PHYH ALOX15B AWAT1 MID1IP1 ALOX15 CYP4B1 CYP1B1 ALOX12 CYP2J2 FAM213B ALOX5 ACOT8 HSD17B12 AMACR SLC25A20 ALOX12B DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE%REACTOME DATABASE ID RELEASE 72%4641262 Disassembly of the destruction complex and recruitment of AXIN to the membrane PPP2CA PPP2CB PPP2R5B PPP2R5A WNT1 GSK3B PPP2R5C CSNK1G2 PPP2R1B DVL1 WNT3A PPP2R1A DVL3 LRP5 LRP6 APC CSNK1A1 FRAT1 DVL2 FRAT2 FZD1 CAV1 PPP2R5D FZD2 FZD5 CTNNB1 WNT8A WNT8B AMER1 AXIN1 PPP2R5E DEFECTIVE PRO-SFTPB CAUSES PULMONARY SURFACTANT METABOLISM DYSFUNCTION 1 (SMDP1) AND RESPIRATORY DISTRESS SYNDROME (RDS)%REACTOME DATABASE ID RELEASE 72%5688031 Defective pro-SFTPB causes pulmonary surfactant metabolism dysfunction 1 (SMDP1) and respiratory distress syndrome (RDS) SFTPB RHO GTPASES ACTIVATE PAKS%REACTOME DATABASE ID RELEASE 72%5627123 RHO GTPases activate PAKs PAK2 FLNA PPP1R12A MYL12B MYLK NF2 CTTN MYH9 PPP1R12B LIMK1 MYH11 MYH14 MYH10 CDC42 PPP1CB PAK1 MYL6 MYL9 RAC1 PAK3 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS%REACTOME%R-HSA-452723.2 Transcriptional regulation of pluripotent stem cells SOX2 SMAD4 FOXD3 SALL1 DPPA4 NR5A1 ZIC3 SALL4 NANOG EPHA1 EPAS1 TDGF1 POU5F1 KLF4 SMAD2 PRDM14 STAT3 LIN28A ZSCAN10 FGF2 PBX1 HIF3A NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY%REACTOME%R-HSA-168333.3 NEP NS2 Interacts with the Cellular Export Machinery NUP85 TPR NUP88 NUP43 RAE1 RANBP2 NUP107 NUP155 NUP188 NUP153 RAN NUP62 NUP35 NUPL2 NDC1 NUP214 SEC13 NUP37 NUP133 NUP210 NUP93 NUP50 NUP54 POM121 XPO1 NUP205 AAAS NUP160 BICARBONATE TRANSPORTERS%REACTOME DATABASE ID RELEASE 72%425381 Bicarbonate transporters SLC4A10 SLC4A7 SLC4A8 AHCYL2 SLC4A9 SLC4A1 SLC4A2 SLC4A3 SLC4A4 SLC4A5 DOWNSTREAM TCR SIGNALING%REACTOME%R-HSA-202424.3 Downstream TCR signaling CUL1 RELA CD4 LCK IKBKB CHUK RIPK2 UBE2V1 CD3G NFKB1 FBXW11 HLA-DPA1 PIK3CB PSMD8 PSMD9 PSMD6 PSMD7 HLA-DQB2 PSMD4 HLA-DQB1 PSMD5 PSMD2 PSMD3 PDPK1 PSMD1 HLA-DQA2 HLA-DQA1 PSMA5 PSMA6 HLA-DRB5 PSMA3 PSMA4 HLA-DRB4 PSMA1 PSMA2 HLA-DPB1 PSME3 HLA-DRA PSME4 PSME1 PSME2 HLA-DRB3 HLA-DRB1 UBA52 PIK3R2 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 NFKBIA IKBKG PSMD13 PSMA7 PSMB10 PSMA8 PRKCQ PSMB6 PSMB7 PSMB4 UBE2D1 PSMB5 PSMB2 UBB PSMB3 CDC34 CARD11 UBC BCL10 PSMB1 PSMF1 TRAV19 RPS27A CD3E SHFM1 CD3D PSMB8 UBE2D2 PSMB9 MALT1 PSMC5 PSMC6 TRAT1 PSMC3 PSMC4 PSMC1 PSMC2 UBE2N INPP5D PIK3R1 PIK3CA BTRC SKP1 TRAF6 TAB2 PTEN MAP3K7 OXIDATIVE DEMETHYLATION OF DNA%REACTOME DATABASE ID RELEASE 72%5221030 Oxidative demethylation of DNA TET2 TET1 TDG TET3 SDK INTERACTIONS%REACTOME%R-HSA-373756.2 SDK interactions SDK1 SDK2 TRYPTOPHAN CATABOLISM%REACTOME DATABASE ID RELEASE 72%71240 Tryptophan catabolism IDO2 IDO1 SLC36A4 AFMID SLC3A2 TDO2 CCBL2 CCBL1 HAAO KMO KYNU ACMSD AADAT SLC7A5 ER-PHAGOSOME PATHWAY%REACTOME DATABASE ID RELEASE 72%1236974 ER-Phagosome pathway PSMD3 PSMD1 PDIA3 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 CALR PSME2 UBA52 PSMD10 PSMB11 PSMD12 PSMD11 SNAP23 PSMD14 IKBKG PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 TIRAP VAMP8 TLR1 PSMB5 PSMB2 TLR6 UBB TLR2 PSMB3 UBC PSMB1 PSMF1 RPS27A STX4 SHFM1 PSMB8 HLA-B PSMB9 TAP2 PSMC5 HLA-C PSMC6 TAP1 PSMC3 HLA-F PSMC4 HLA-G PSMC1 HLA-E PSMC2 IKBKB TAPBP SEC61A2 SEC61A1 SEC61G CHUK SEC61B VAMP3 CD36 MYD88 HLA-A B2M PSMD8 BTK PSMD9 PSMD6 SEC22B LY96 PSMD7 PSMD4 CD14 PSMD5 TLR4 PSMD2 MPS IX - NATOWICZ SYNDROME%REACTOME%R-HSA-2206280.2 MPS IX - Natowicz syndrome HYAL1 DEFECTIVE ABCD4 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA, CBLJ TYPE (MAHCJ)%REACTOME%R-HSA-5683329.1 Defective ABCD4 causes methylmalonic aciduria and homocystinuria, cblj type (MAHCJ) ABCD4 OAS ANTIVIRAL RESPONSE%REACTOME%R-HSA-8983711.2 OAS antiviral response FLNA DDX58 OAS1 PDE12 OAS2 OAS3 ABCE1 OASL RNASEL NEGATIVE REGULATION OF NOTCH4 SIGNALING%REACTOME DATABASE ID RELEASE 72%9604323 Negative regulation of NOTCH4 signaling PSMD3 AKT1 CUL1 PSMD1 YWHAZ PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME1 PSME2 UBA52 PSMD10 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 UBB PSMB3 UBC PSMB1 PSMF1 RPS27A SHFM1 PSMB8 PSMB9 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 TACC3 NOTCH4 SKP1 PSMD8 PSMD9 PSMD6 RBX1 PSMD7 PSMD4 PSMD5 PSMD2 NRCAM INTERACTIONS%REACTOME DATABASE ID RELEASE 72%447038 NrCAM interactions NRP2 DLG1 DLG4 DLG3 ANK1 NRCAM CNTN2 INFECTION WITH MYCOBACTERIUM TUBERCULOSIS%REACTOME%R-HSA-9635486.2 Infection with Mycobacterium tuberculosis PGK1 GSK3A DUSP16 SFPQ ATP6V1H ENO1 KPNA1 UBA52 HGS VPS33B RAB5A CORO1A MRC1 RAB7A NOS2 TRIM27 UBB CTSG TLR2 UBC B2M RNF213 RPS27A KPNB1 MAPK1 MAPK3 LTF REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA%REACTOME%R-HSA-3134975.2 Regulation of innate immune responses to cytosolic DNA TRIM32 DDX41 TBK1 TRIM21 ZBP1 TMEM173 UBB TRIM56 DTX4 UBC NLRP4 RPS27A UBA52 TREX1 IRF3 LATE ENDOSOMAL MICROAUTOPHAGY%REACTOME DATABASE ID RELEASE 72%9615710 Late endosomal microautophagy TSG101 PCNT MVB12B MVB12A VPS37C VPS37D CHMP2A VPS37A VPS37B CHMP2B CHMP4C UBAP1 CHMP4B UBA52 CHMP3 CHMP4A CHMP6 CHMP7 VPS28 PLIN3 RNASE1 PLIN2 PARK7 HDAC6 UBB CETN1 UBC HBB CFTR RPS27A HSPA8 IFT88 ARL13B BIOSYNTHESIS OF DHA-DERIVED SULFIDO CONJUGATES%REACTOME DATABASE ID RELEASE 72%9026395 Biosynthesis of DHA-derived sulfido conjugates LTC4S GSTM4 VIRAL MRNA TRANSLATION%REACTOME%R-HSA-192823.3 Viral mRNA Translation RPL26 GRSF1 RPL29 RPL10L RPS4X RPL10A RPL28 RPS3A RPL7A RPL23A FAU RPL41 RPS27L RPL3L UBA52 RPL37A RPS26 RPS25 RPS28 RPS27 RPL36A RPS29 RPL35A RPS20 RPS21 RPS24 RPS23 RPL22L1 RPS4Y2 RPL10 RPS4Y1 RPS27A RPL12 RPL13A RPL11 RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL27A RPL26L1 RPL4 RPL39L RPL5 RPL30 RPL3 RPL32 RPL31 RPS9 RPS7 RPL34 RPS8 RPL8 RPS5 RPL9 RPS6 RPL6 RPL7 RPSA RPL36 RPS15 RPS14 RPL35 RPS17 RPL38 RPS16 RPL37 RPL39 RPS19 RPS15A RPL18A RPL36AL RPS18 RPLP1 RPL21 RPL23 RPS11 RPL22 RPLP0 RPS10 DNAJC3 RPS13 RPS12 RPLP2 RPL24 RPL27 METABOLISM OF FAT-SOLUBLE VITAMINS%REACTOME%R-HSA-6806667.4 Metabolism of fat-soluble vitamins VKORC1L1 SDC4 SDC2 SDC3 TTR APOM RETSAT BCO2 APOE BCO1 APOB APOC3 PLB1 UBIAD1 APOC2 SDC1 VKORC1 AKR1B10 PNLIP GPIHBP1 LRP1 RDH11 LPL GPC1 GPC3 GPC2 LRAT GPC5 LRP2 GPC4 GPC6 LDLR LRP8 HSPG2 AKR1C1 APOA2 APOA1 AKR1C3 APOA4 RBP4 LRP10 RBP2 LRP12 AKR1C4 CLPS RBP1 AGRN TTPA PRPP BIOSYNTHESIS%REACTOME%R-HSA-73843.2 PRPP biosynthesis PRPS2 PRPS1 REGULATION OF GENE EXPRESSION IN BETA CELLS%REACTOME%R-HSA-210745.1 Regulation of gene expression in beta cells AKT1 HNF4G NEUROD1 NKX6-1 NKX2-2 PDX1 SLC2A2 HNF1A INS MAFA IAPP RFX6 PAX6 GCK FOXA3 AKT2 AKT3 FOXA2 FOXO1 LONG-TERM POTENTIATION%REACTOME DATABASE ID RELEASE 72%9620244 Long-term potentiation GRIA2 CAMK2D CAMK2A NEFL NRG1 GRIN2C GRIN2B GRIN2D GRIN1 CAMK2G LRRC7 DLG2 DLG1 ACTN2 DLG4 DLG3 NRGN SRC GRIN2A GRIA1 CAMK2B DEFECTIVE POMGNT1 CAUSES MDDGA3, MDDGB3 AND MDDGC3%REACTOME%R-HSA-5083628.1 Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3 POMGNT1 DAG1 GLYCOGEN SYNTHESIS%REACTOME%R-HSA-3322077.4 Glycogen synthesis PPP1R3C GBE1 GYS2 GYS1 PGM2 PGM2L1 PGM1 UBB UBC EPM2A RPS27A UBA52 UGP2 GYG2 GYG1 NHLRC1 ABASIC SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 72%73930 Abasic sugar-phosphate removal via the single-nucleotide replacement pathway APEX1 POLB RUNX1 INTERACTS WITH CO-FACTORS WHOSE PRECISE EFFECT ON RUNX1 TARGETS IS NOT KNOWN%REACTOME%R-HSA-8939243.1 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known CBX6 SMARCA4 YAF2 RYBP CBFB RUNX1 PBRM1 ACTL6B SMARCD3 CSNK2A1 CSNK2A2 EP300 SMARCB1 HIPK2 BMI1 ARID1A RNF2 ARID1B PCGF5 SMARCD1 CBX8 CSNK2B SMARCD2 PHC2 SMARCC1 PHC1 SMARCC2 RING1 CBX4 AUTS2 ARID2 SMARCE1 CBX2 ACTL6A PHC3 SMARCA2 ERYTHROCYTES TAKE UP OXYGEN AND RELEASE CARBON DIOXIDE%REACTOME DATABASE ID RELEASE 72%1247673 Erythrocytes take up oxygen and release carbon dioxide HBB RHAG SLC4A1 CA1 AQP1 CA2 CA4 HBA2 HBA1 PROSTANOID LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 72%391908 Prostanoid ligand receptors PTGIR PTGER1 PTGER3 PTGDR2 PTGDR PTGER4 PTGFR TBXA2R PTGER2 ERYTHROPOIETIN ACTIVATES RAS%REACTOME DATABASE ID RELEASE 72%9027284 Erythropoietin activates RAS EPO SHC1 RAPGEF1 JAK2 LYN HRAS VAV1 SOS1 CRKL NRAS IRS2 EPOR INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME DATABASE ID RELEASE 72%2514859 Inactivation, recovery and regulation of the phototransduction cascade CNGA1 RHO RCVRN SAG METAP1 PDE6B METAP2 PDE6A NMT1 CNGB1 PRKCA GNB1 NMT2 GNGT1 FNTA GUCY2D PRKCQ GUCY2F GNAT1 GUCA1B RGS9BP GUCA1A GUCA1C CAMKMT GRK1 GRK7 PPEF1 FNTB PDE6G CELL SURFACE INTERACTIONS AT THE VASCULAR WALL%REACTOME%R-HSA-202733.4 Cell surface interactions at the vascular wall SDC4 SLC7A7 SDC2 SLC7A8 SDC3 ITGAM SLC7A9 ITGB2 ITGAL TSPAN7 ITGAX CD74 APOB PICK1 SDC1 GP6 TREM1 CD99 CD84 MIF SIRPG VPREB3 IGKV1-12 VPREB1 PSG1 PSG3 PSG2 AMICA1 PSG9 FCAMR PSG8 PSG5 PSG4 PSG6 IGKV2D-28 GYPA IGKV4-1 GYPC GYPB CD99L2 PSG11 GLG1 IGHA1 IGKV2D-30 SELE SELP ESAM JCHAIN SPN CEACAM5 CD48 SELPLG EPCAM FCER1G PPIL2 MERTK ATP1B3 MMP1 JAM2 CD2 CEACAM3 LCK JAM3 IGLL1 ATP1B2 CEACAM1 CD244 IGKV3-11 CEACAM6 ATP1B1 LYN CEACAM8 CD47 YES1 PPIA CD58 IGKV2-28 IGKV3D-20 SIRPA SLC7A5 HRAS CD44 GPC1 NRAS SELL ITGB3 PIK3CB IGKV5-2 ITGAV PTPN11 SLC3A2 GAS6 PTPN6 PIK3R2 PROS1 FYN SLC16A1 THBD PF4V1 CD177 CAV1 FN1 L1CAM ITGA5 F2 SLC16A8 PROCR SLC16A3 PROC PF4 CXADR INPP5D ITGA6 SHC1 OLR1 PIK3R1 TNFRSF10B PIK3CA PLCG1 TNFRSF10A SOS1 ITGA4 TNFRSF10D TGFB1 F11R MAG ITGB1 BSG GRB7 ANGPT4 ANGPT2 ANGPT1 DOK2 GRB14 SLC7A11 TEK SLC7A10 ITGA3 SLC7A6 INFLAMMASOMES%REACTOME DATABASE ID RELEASE 72%622312 Inflammasomes CASP1 NLRC4 SUGT1 BCL2L1 AIM2 BCL2 NLRP1 HSP90AB1 P2RX7 TXNIP MEFV TXN NFKB1 NFKB2 PYCARD NLRP3 APP PANX1 RELA PSTPIP1 NCAM1 INTERACTIONS%REACTOME%R-HSA-419037.1 NCAM1 interactions NCAM1 CACNB1 CACNB4 NRTN GFRA1 GFRA2 GFRA4 CACNA1H CACNA1G CACNA1S CACNA1I PRNP PSPN GDNF COL4A2 ARTN COL4A1 COL6A2 CNTN2 CACNA1D ST8SIA4 COL4A4 CACNA1C CACNB2 COL6A1 CACNB3 COL4A3 COL9A1 ST8SIA2 COL6A3 COL4A5 COL9A3 COL6A6 NCAN COL9A2 COL6A5 AGRN TELOMERE C-STRAND SYNTHESIS INITIATION%REACTOME%R-HSA-174430.3 Telomere C-strand synthesis initiation OBFC1 PRIM2 POLA1 PRIM1 POLA2 CTC1 TEN1 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS)%REACTOME%R-HSA-373076.6 Class A 1 (Rhodopsin-like receptors) CXCL6 CXCL9 CXCL3 GPER1 CXCL13 CXCL2 QRFPR CX3CL1 SSTR1 CXCL5 SSTR2 CXCL16 SSTR4 CCRL2 SSTR5 HTR6 CCR9 CNR2 HTR7 CCR8 CNR1 CCR7 HTR1E CCR6 HTR1F CCR4 HTR1D CCR3 HTR2B CCK CCR2 HTR1A OPN1SW HTR1B XCL2 ACKR1 RXFP4 HTR2C XCL1 GRPR HTR2A CX3CR1 HTR4 RXFP3 CCL13 PROK2 CCL11 HTR5A PROK1 CCL3L1 CMKLR1 CCL3L3 TRHR CXCR5 GALR3 CXCR6 APP GALR2 CCL7 GALR1 CCL5 RXFP1 CXCR3 RXFP2 CCL4 CCL3 GPR183 CYSLTR1 CCL2 PNOC CCL1 GPR132 CCL19 OPN1LW CCL17 CCL16 PTGDR CCR10 OPN1MW RGR CCL25 LHCGR TAAR8 CCR1 GPR4 TAAR9 CCL22 GPR143 HCAR2 SSTR3 TAAR6 XCR1 HCAR3 TAAR5 CCL21 HCAR1 TAAR2 CCL20 CHRM1 TAAR1 CXCL10 CXCL11 CHRM4 ACKR4 ACKR3 CHRM5 ACKR2 CCL28 MCHR1 CCL27 MTNR1A MTNR1B ADRB1 ADRB2 MC2R TRH HRH2 INSL5 DRD1 DRD5 OXTR RRH AVP EDNRA EDNRB UTS2R MC1R GPR37L1 RLN2 UTS2B RLN3 PTGFR NLN ANXA1 AGT PPY NTSR1 NTSR2 NMB NMBR MC4R NMS NMU CHRM3 QRFP INSL3 BRS3 CCKAR GPR39 FFAR3 FFAR2 FSHB EDN1 EDN2 AVPR2 EDN3 AVPR1B AVPR1A GPBAR1 CCKBR NPB MC3R PTGER1 PTGER3 ADORA2A ADRB3 NPW KISS1R ADORA2B FSHR F2RL1 F2RL2 F2RL3 NPSR1 PTGER4 PMCH NPY2R GHSR NPY1R PTGER2 APLNR SUCNR1 NTS NPS OPN4 OPN3 C3 PSAP GPHA2 OPN5 P2RY11 PYY NMUR2 NMUR1 TSHR MC5R MLNR GPHB5 HEBP1 BDKRB2 BDKRB1 C3AR1 NPY5R CORT ADRA2C NPY4R OPRL1 ADRA2A S1PR3 S1PR2 S1PR5 S1PR4 OPRK1 KISS1 KNG1 HRH1 HRH3 HRH4 F2R F2 PF4 FPR1 FPR2 CGA CHRM2 FFAR1 AGTR1 NPY TACR2 TACR3 TAC3 TACR1 CYSLTR2 TAC1 CXCL8 DRD2 DRD3 DRD4 FFAR4 PPBP OPRD1 TSHB GPR17 LTB4R2 LTB4R GRP RHO OPRM1 S1PR1 P2RY1 CXCR1 CXCR2 POMC SAA1 C5AR2 C5AR1 C5 CXCL1 P2RY12 CXCL12 PTAFR PTGIR P2RY13 P2RY10 P2RY14 LPAR4 P2RY6 P2RY4 LHB LPAR6 ADORA3 P2RY2 ADORA1 CCR5 CXCR4 ADRA1D PDYN ADRA1B ADRA1A AGTR2 FPR3 NPBWR1 NPBWR2 HCRT GPR18 GPR37 GPR35 GPR31 PROKR1 PROKR2 GPR55 GPR68 GPR65 UTS2 ECE1 PRLHR HCRTR2 HCRTR1 APLN OPN1MW2 NPFFR2 NPFFR1 OXER1 NPFF KEL LPAR1 LPAR2 LPAR3 PENK LPAR5 TBXA2R GNRH2 GNRH1 PTGDR2 MLN GNRHR OXGR1 GAL PRLH XK MCHR2 OXT SST INTERLEUKIN-20 FAMILY SIGNALING%REACTOME DATABASE ID RELEASE 72%8854691 Interleukin-20 family signaling IFNL2 IFNL1 STAT1 IFNL3 STAT2 PTPN11 IL20RA IL20RB IL22RA2 IL22RA1 JAK2 IL10RB STAT4 IFNLR1 IL22 IL20 STAT5A STAT5B IL26 IL24 IL19 TYK2 JAK1 JAK3 STAT3 ORGANIC CATION TRANSPORT%REACTOME%R-HSA-549127.1 Organic cation transport SLC22A3 SLC22A5 SLC22A2 SLC22A4 RSC1A1 SLC22A1 SLC22A15 SLC22A16 SLC22A18 RUNX1 DOWNSTREAM SIGNALING OF ACTIVATED FGFR2%REACTOME DATABASE ID RELEASE 72%5654696 Downstream signaling of activated FGFR2 HRAS FRS2 PTPN11 FRS3 FGF16 FGF7 FGF18 NRAS GAB1 PIK3R1 FGF6 PIK3CA FGF9 PLCG1 SOS1 FGF20 FGF1 FGF2 FGF23 FGF3 FGF22 FGF10 FGF4 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 72%68962 Activation of the pre-replicative complex ORC4 ORC6 RPA1 ORC1 POLE RPA2 ORC3 ORC2 CDT1 CDC7 RPA3 CDC6 POLA1 POLA2 MCM7 MCM8 MCM10 DBF4 MCM3 MCM4 MCM5 MCM6 MCM2 PRIM2 PRIM1 CDC45 RPA4 POLE4 POLE2 CDK2 POLE3 GMNN ORC5 RAB REGULATION OF TRAFFICKING%REACTOME%R-HSA-9007101.3 Rab regulation of trafficking RAB1B TRAPPC6A TRAPPC6B RAB18 RAB3GAP2 RAB3GAP1 RAB10 TBC1D10C RAB4A RAB5C RAB3IP RAB11A RAB27B GGA2 RAB27A GGA1 RIC1 RAB14 RAB9B RAB39A RAB33B RGP1 GABARAPL2 RAB8A RAB6A ULK1 GABARAP MAP1LC3B DENND5B RABGEF1 RINL AKT2 TRAPPC12 AKT3 TRAPPC11 OPTN DENND5A CHM TRAPPC13 TBC1D10A TBC1D10B SYTL1 TBC1D24 RAB3A TBC1D25 CHML DENND6B RIN3 AKT1 DENND6A GDI1 RIN1 GDI2 RIN2 TBC1D13 TBC1D14 SBF1 TBC1D17 TBC1D15 SBF2 TBC1D16 ANKRD27 CCZ1B DENND4B DENND4A HPS1 CCZ1 HPS4 TRAPPC8 MON1A MON1B DENND1C RAB32 DENND1B DENND1A RAB35 DENND2D RAB5A DENND2C RAB38 DENND2A RAB3IL1 RAB7A TBC1D2 TBC1D3 RABEP1 ALS2 TBC1D7 RABGAP1 DENND3 ALS2CL ST5 GGA3 RAB21 ARF6 RAB12 RAB13 TSC2 TSC1 RAB39B TRAPPC4 RAB8B RAB33A RAB7B RAB6B RAB11B RAB9A TRAPPC10 GAPVD1 RAB31 TRAPPC2L TBC1D20 TRAPPC2 YWHAE TRAPPC3 RAB5B TRAPPC5 TRAPPC9 TRAPPC1 RAB1A AMINO ACID AND DERIVATIVE METABOLISM%REACTOME%R-HSA-71291.6 Amino acid and derivative metabolism RPL26 SLC45A2 RPL29 RPS4X RPL28 DBT RPS3A PRODH2 DCT RPL41 RPL3L DDC GLUD1 ALDH6A1 DDO SLC6A7 GLUD2 SLC6A8 OGDH GLS2 ADO HIBADH IL4I1 PHGDH TDO2 AHCY IVD OCA2 TXNRD1 RPL10 RPL12 RPL11 RPS3 RPL14 ETHE1 RPL13 RPS2 RPL15 RPL18 IDO2 RPL17 HPD RPL19 IDO1 OTC TXN2 OAZ1 SLC44A1 OAZ2 KMO OAZ3 SLC5A5 IYD NNMT RPS9 HAO1 RPS7 RPS8 RPS5 RPS6 RPSA AANAT EEFSEC BHMT PDHA2 ASMT PDHA1 MRI1 RPLP1 RPLP0 TAT ASNS RPLP2 ARG2 ARG1 SERINC1 SERINC3 SERINC2 SERINC5 NAT8L SERINC4 GADL1 RPL7A SLC3A2 CBS DLD AMT CRYM RPS27L INMT ASPG RPL37A ASPA CARNS1 SUOX TYRP1 RPL36A AADAT SARDH RPL35A ASS1 ECHS1 CDO1 GAMT MTAP RPL22L1 HNMT SAT1 LIPT2 LIPT1 TPH2 GLUL RPS4Y2 SLC25A44 MCCC2 RPS4Y1 SDSL PIPOX MCCC1 ACMSD ACAT1 ALDH7A1 CGA NDUFAB1 SLC25A2 SQRDL ADI1 PAH NAALAD2 ASL RPL39L GPT SLC25A15 CSAD ACADSB AUH PAPSS2 PAPSS1 RPS15A PPM1K CKB DLAT CKM HSD17B10 CKMT2 SLC25A21 PCBD1 C9orf41 GNMT AGMAT GATM HRSP12 RPL10L RPL10A NQO1 RPL23A FAH DIO1 FAU TMLHE CCBL2 DIO2 CKMT1B CCBL1 DIO3 SDS PSPH TSTD1 SECISBP2 FOLH1 PHYKPL TPO ASRGL1 SHMT1 GCAT AZIN2 GCDH AZIN1 AMD1 NMRAL1 AFMID FTCD DHTKD1 SLC25A10 DARS SLC25A12 SARS EPRS GLS AIMP1 KYNU RPL13A SLC25A13 AIMP2 KARS RIMKLA TST QARS LARS RIMKLB TSHB ALDH9A1 RARS HIBCH MARS PSTK PDHB IARS TH EEF1E1 RPL27A GOT1 ENOPH1 GOT2 BCKDK PSAT1 CTH AASS ACAD8 SLC7A5 SCLY MTRR RPS15 RPS14 RPS17 RPS16 RPS19 RPL18A RPL36AL RPS18 OAT RPS11 RPS10 RPS13 ODC1 PSMD8 DLST PSMD9 RPS12 PSMD6 PDHX PSMD7 CKMT1A PSMD4 BBOX1 PSMD5 PSMD2 ALDH4A1 PSMD3 PSMD1 PSMA5 PSMA6 MAT1A PSMA3 PSMA4 PSMA1 LIAS PSMA2 PSME3 PSME4 PSME1 PYCR1 PSME2 PYCR2 UBA52 TYR RPS26 PSMD10 PSMB11 RPS25 PSMD12 RPS28 SMS HAL PSMD11 RPS27 PSMD14 PRODH PSMD13 RPS29 PSMA7 RPS20 PSMB10 RPS21 PSMA8 RPS24 RPS23 PSMB6 PSMB7 QDPR PSMB4 CPS1 BHMT2 PSMB5 PSMB2 AMDHD1 PSMB3 MTR PSMB1 PSMF1 AGXT2 HAAO SLC6A12 HDC RPS27A BCKDHA SLC6A11 TPH1 BCKDHB SHFM1 PSMB8 PSMB9 PSMC5 PSMC6 DUOX1 PSMC3 PSMC4 CHDH PSMC1 APIP PSMC2 DUOX2 PAOX AGXT BCAT1 RPL26L1 RPL4 PNMT RPL5 RPL30 BCAT2 RPL3 RPL32 RPL31 HGD GLDC SRM RPL34 SRR RPL8 RPL9 RPL6 RPL7 SLC36A4 GCSH RPL36 GSTZ1 MPST UROC1 RPL35 NAGS DMGDH RPL38 RPL37 RPL39 GRHPR HYKK RPL21 RPL23 SEPSECS RPL22 DAO PXMP2 HOGA1 PYCRL RPL24 RPL27 DBH CHOLINE CATABOLISM%REACTOME DATABASE ID RELEASE 72%6798163 Choline catabolism ALDH7A1 SLC44A1 DMGDH BHMT CHDH SARDH RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS.%REACTOME DATABASE ID RELEASE 72%163200 Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. ATP5G2 UQCR11 NDUFA7 ATP5G1 UQCR10 NDUFA6 NDUFA5 NDUFA3 ATP5F1 NDUFA2 NDUFA1 ATP5C1 ETFDH NDUFAF6 NDUFAF7 NDUFAF4 NDUFAF5 NDUFAF2 NDUFAF3 TMEM126B NDUFAF1 MT-ND6 MT-ND4 MT-ND5 ATP5S MT-ND2 MT-ATP6 MT-ND3 MT-ND1 ATP5J ATP5I ATP5H ATP5O ATP5L ATP5B NDUFA4 ATP5E MT-CO1 ATP5D UQCRC1 MT-ATP8 UQCRC2 COX7A2L SCO1 TIMMDC1 SCO2 MT-CO2 MT-CO3 SDHC SDHD SDHA SDHB NDUFB10 NDUFB11 SURF1 ACAD9 COX7B NUBPL ATP5A1 ECSIT COX7C COX8A UCP1 COX5B COX5A UCP3 UCP2 PM20D1 CYC1 NDUFV3 NDUFV2 UQCRB NDUFV1 COX6C LRPPRC UQCRH UQCRFS1 TACO1 COX6A1 UQCRQ NDUFS8 NDUFS7 MT-CYB NDUFS6 NDUFS5 NDUFS4 ETFA NDUFS3 ETFB NDUFAB1 COX6B1 NDUFS2 NDUFS1 COX16 COX18 COX11 COX14 NDUFC2 NDUFA13 NDUFC1 NDUFA11 NDUFA12 TRAP1 NDUFA10 COQ10B COQ10A SLC25A14 ATP5J2 NDUFB9 NDUFB8 NDUFB7 NDUFB6 NDUFB5 NDUFB4 NDUFB3 NDUFB2 NDUFB1 CYCS COX20 SLC25A27 COX4I1 NDUFA9 ATP5G3 NDUFA8 TRANSCRIPTION FROM MITOCHONDRIAL PROMOTERS%REACTOME%R-HSA-75944.3 Transcription from mitochondrial promoters TFB2M POLRMT TFAM MTERF1 P53-DEPENDENT G1 DNA DAMAGE RESPONSE%REACTOME%R-HSA-69563.3 p53-Dependent G1 DNA Damage Response PSMD3 PSMD1 ZNF385A PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 CCNA2 CCNA1 UBA52 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 CDKN2A PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 UBB PSMB3 RFWD2 UBC PSMB1 PSMF1 RPS27A CHEK2 SHFM1 PSMB8 PSMB9 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 CCNE2 CCNE1 TP53 PCBP4 ATM CDK2 MDM2 CDKN1A MDM4 CDKN1B PHF20 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE%REACTOME%R-HSA-71406.1 Pyruvate metabolism and Citric Acid (TCA) cycle SUCLG2 SUCLG1 MPC1 MPC2 DLD FH FAHD1 OGDH SLC16A1 LDHAL6A LDHAL6B IDH3B IDH3A SLC16A8 SLC16A3 ACO2 LDHC LDHB LDHA ADHFE1 VDAC1 PDHB PDPR PDP1 ME1 ME3 PDP2 IDH3G MDH2 ME2 SDHC SDHD SDHA SDHB GSTZ1 SUCLA2 RXRA CS L2HGDH GLO1 PDHA2 NNT IDH2 PDHA1 PPARD DLAT PDK4 PDK3 BSG PDK2 DLST D2HGDH PDK1 PDHX SLIT2:ROBO1 INCREASES RHOA ACTIVITY%REACTOME%R-HSA-8985586.1 SLIT2:ROBO1 increases RHOA activity MYO9B SLIT2 ROBO1 RHOA SPERM MOTILITY AND TAXES%REACTOME%R-HSA-1300642.1 Sperm Motility And Taxes KCNU1 CATSPER1 CATSPERB CATSPER3 CATSPERD CATSPER2 CATSPERG CATSPER4 HVCN1 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM%REACTOME%R-HSA-196741.2 Cobalamin (Cbl, vitamin B12) transport and metabolism ABCC1 GIF MTRR PRSS1 CD320 MMAB PRSS3 CTRC ABCD4 AMN TCN2 TCN1 CUBN MTR CTRB2 CTRB1 LMBRD1 MMAA MMACHC MMADHC MUT INTERLEUKIN-37 SIGNALING%REACTOME%R-HSA-9008059.2 Interleukin-37 signaling PTPN13 CASP1 IL37 PTPN20 PTPN12 PTPN23 TBK1 IL18R1 PTPN11 IL18BP PTPN18 PTPN14 SIGIRR PTPN9 PTPN7 PTPN2 PTPN4 PTPN5 PTPN6 SMAD3 STAT3 DEFECTIVE SLC22A5 CAUSES SYSTEMIC PRIMARY CARNITINE DEFICIENCY (CDSP)%REACTOME DATABASE ID RELEASE 72%5619053 Defective SLC22A5 causes systemic primary carnitine deficiency (CDSP) SLC22A5 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF)%REACTOME DATABASE ID RELEASE 72%1655829 Regulation of cholesterol biosynthesis by SREBP (SREBF) SEC24B DHCR7 SEC24A GPAM ELOVL6 TBL1X TM7SF2 LSS TGS1 ACACB HELZ2 ACACA SEC24D SEC24C INSIG2 TBL1XR1 INSIG1 SMARCD3 SAR1B FDPS SREBF2 CHD9 HMGCS1 GGPS1 KPNB1 SP1 FASN CARM1 SC5D PMVK MVD NFYA MVK FDFT1 NFYB NFYC SQLE MBTPS1 CYP51A1 SCAP RAN MBTPS2 NCOA1 SCD NCOA2 CREBBP NCOA6 MTF1 IDI1 SEC23A RXRA PPARA MED1 DEFECTIVE LFNG CAUSES SCDO3%REACTOME%R-HSA-5083630.2 Defective LFNG causes SCDO3 NOTCH2 NOTCH3 NOTCH4 LFNG NOTCH1 SPHINGOLIPID DE NOVO BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 72%1660661 Sphingolipid de novo biosynthesis SPHK1 ACER2 SPTSSB ACER1 SPTSSA ACER3 SGPL1 CERS3 CERS4 CERS5 CERS6 SPTLC1 SPTLC2 SPTLC3 CSNK1G2 FA2H SPHK2 VAPA VAPB CERS1 SGPP2 CERS2 SGPP1 ALDH3B2 ALDH3B1 PPM1L SGMS2 PRKD3 PRKD2 KDSR PRKD1 OSBP DEGS1 DEGS2 SAMD8 ORMDL2 ORMDL3 PPAP2B ORMDL1 PPAP2A PPAP2C PI3K AKT SIGNALING IN CANCER%REACTOME%R-HSA-2219528.1 PI3K AKT Signaling in Cancer PDPK1 KIT AKT1 PDGFB VAV1 ESR2 STRN PIK3AP1 PTPN11 RAC2 RHOG MAPKAP1 FGF6 PIK3R2 FGF9 FGF20 FGF1 FGF2 RICTOR FGF23 FGF3 FYN FGF22 FOXO6 FGF10 FGF4 FOXO4 NR4A1 RPS6KB2 MTOR HGF PIK3R3 MET KLB IRS1 IRS2 CREB1 FGF19 FGFR4 FOXO1 CD86 TRAT1 LCK CD80 TSC2 CD28 NRG1 GSK3A FOXO3 CHUK NRG2 FRS2 BAD CASP9 NRG3 FGF16 FGF7 NRG4 PIK3CD FGF18 ESR1 GSK3B PDGFRA EGF GAB1 PIK3R1 EGFR PIK3CA ERBB2 AKT1S1 PRR5 BTC EPGN TGFA AREG HBEGF MDM2 EREG CDKN1A CDKN1B CD19 PIK3CB AKT2 AKT3 MLST8 PTEN SRC RAC1 PDGFRB NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY%REACTOME%R-HSA-383280.1 Nuclear Receptor transcription pathway RARA RARB HNF4G ESR2 THRB NR2C1 NR4A2 NR1D1 NR5A1 ESR1 NR2E1 RORC NCOR2 NR4A1 NCOR1 VDR AR RXRG RXRB RXRA PPARG PPARA RORA THRA MED1 PPARD RORB NR2C2 HNF4A NR2C2AP ESRRB NR1H2 NR2F1 NR1D2 ESRRG NR0B2 PGR ESRRA NRBP1 NR2F6 RARG SYNTHESIS OF PG%REACTOME%R-HSA-1483148.2 Synthesis of PG PTPMT1 PLD4 PLD6 PLD1 PLD3 PLD2 PGS1 CDS2 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS%REACTOME%R-HSA-1606322.1 ZBP1(DAI) mediated induction of type I IFNs IKBKB NKIRAS1 NKIRAS2 TBK1 CHUK ZBP1 RIPK3 DHX9 DTX4 NFKB1 NFKB2 NLRP4 RIPK1 IRF3 TICAM1 NFKBIA IKBKG TLR3 MYD88 RELA NFKBIB METHYLATION%REACTOME%R-HSA-156581.4 Methylation N6AMT1 MTRR TPMT MAT1A AS3MT MAT2B AHCY MTR MAT2A GSTO1 TRMT112 CYP1A2 COMT NNMT SIGNALING BY FGFR IN DISEASE%REACTOME%R-HSA-1226099.4 Signaling by FGFR in disease BAG4 POLR2E POLR2F POLR2H FGFR1OP POLR2K POLR2L TRIM24 FGF6 FGF9 FGF20 FGF1 FGF2 FGF23 FGF3 FGF22 FGF10 FGF4 STAT5A STAT5B CPSF6 ZMYM2 FGFR1OP2 MYO18A FGFR1 GAB2 FGFR4 NCBP1 NCBP2 GTF2F1 GTF2F2 POLR2A POLR2B POLR2C STAT1 POLR2D POLR2G ERLIN2 FRS2 CUX1 FGF16 FGF7 POLR2I FGFR3 POLR2J FGF18 GAB1 PIK3R1 FGFR2 PIK3CA PLCG1 SOS1 BCR HRAS LRRFIP1 NRAS STAT3 MRNA 3'-END PROCESSING%REACTOME DATABASE ID RELEASE 72%72187 mRNA 3'-end processing CPSF4 CPSF7 CPSF1 CSTF3 CPSF3 CSTF2 CPSF2 CSTF2T WDR33 NUDT21 FIP1L1 PABPN1 CLP1 PCF11 PAPOLA CSTF1 SYMPK NCBP1 NCBP2 EIF4A3 CASC3 MAGOH THOC1 THOC3 THOC2 THOC5 THOC7 CDC40 THOC6 SRRM1 DDX39A DDX39B ZC3H11A SARNP SRSF2 SRSF3 SRSF4 SRSF5 SRSF6 SRSF7 SLU7 SRSF9 FYTTD1 LUZP4 RBM8A POLDIP3 SRSF1 U2AF1 U2AF1L4 U2AF2 DHX38 SRSF11 CHTOP UPF3B MAGOHB RNPS1 NRAGE SIGNALS DEATH THROUGH JNK%REACTOME DATABASE ID RELEASE 72%193648 NRAGE signals death through JNK BCL2L11 VAV1 VAV2 ECT2 ARHGEF33 ARHGEF35 ARHGEF37 ARHGEF7 ARHGEF39 ARHGEF38 NET1 RASGRF2 ARHGEF10L AATF AKAP13 MCF2L MAPK8 ARHGEF11 TIAM1 ARHGEF10 ARHGEF12 PLEKHG2 ARHGEF15 ARHGEF17 PLEKHG5 ARHGEF16 ARHGEF19 ARHGEF9 ARHGEF3 ARHGEF4 ARHGEF1 ARHGEF2 SOS2 ARHGEF5 NGFR FGD1 FGD2 FGD3 GNA13 FGD4 MCF2 BAD SOS1 TRIO ARHGEF18 ITSN1 PREX1 ARHGEF40 OBSCN NGEF ARHGEF6 ARHGEF26 MAGED1 RAC1 KALRN TIAM2 VAV3 NGF ABR DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE%REACTOME DATABASE ID RELEASE 72%3359467 Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE MTRR MTR TYROSINE CATABOLISM%REACTOME%R-HSA-8963684.1 Tyrosine catabolism HPD TAT GSTZ1 FAH HGD PI3K EVENTS IN ERBB4 SIGNALING%REACTOME DATABASE ID RELEASE 72%1250342 PI3K events in ERBB4 signaling PIK3R1 NRG1 PIK3CA NRG2 BTC NRG3 NRG4 HBEGF EREG FREE FATTY ACIDS REGULATE INSULIN SECRETION%REACTOME%R-HSA-400451.1 Free fatty acids regulate insulin secretion FFAR1 PLCB2 GNA14 GNA15 CD36 ACSL4 PLCB3 ACSL3 GNA11 GNAQ PLCB1 PROTON-COUPLED NEUTRAL AMINO ACID TRANSPORTERS%REACTOME%R-HSA-428559.1 Proton-coupled neutral amino acid transporters SLC36A1 SLC36A2 DEFECTIVE SLC26A2 CAUSES CHONDRODYSPLASIAS%REACTOME%R-HSA-3560792.2 Defective SLC26A2 causes chondrodysplasias SLC26A2 GSD XV%REACTOME%R-HSA-3814836.2 GSD XV GYS1 GYG1 RELEASE%REACTOME DATABASE ID RELEASE 72%168298 Release INTERLEUKIN-35 SIGNALLING%REACTOME DATABASE ID RELEASE 72%8984722 Interleukin-35 Signalling JAK2 EBI3 IL6ST STAT1 JAK1 STAT4 STAT3 IL12RB2 IL27RA IL12A CANX TYK2 RUNX2 REGULATES GENES INVOLVED IN DIFFERENTIATION OF MYELOID CELLS%REACTOME DATABASE ID RELEASE 72%8941333 RUNX2 regulates genes involved in differentiation of myeloid cells LGALS3 CBFB RUNX1 PEXOPHAGY%REACTOME%R-HSA-9664873.1 Pexophagy MAP1LC3B UBC NBR1 RPS27A UBA52 USP30 PEX5 ATM SQSTM1 UBB EPAS1 NETRIN MEDIATED REPULSION SIGNALS%REACTOME%R-HSA-418886.1 Netrin mediated repulsion signals UNC5B NTN1 UNC5C UNC5D PTPN11 SRC UNC5A DCC N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI%REACTOME%R-HSA-975576.1 N-glycan antennae elongation in the medial trans-Golgi ST3GAL4 CGA FUCA1 MAN2A2 MAN2A1 B4GALT6 LHB MGAT4C MGAT4A B4GALT4 MGAT4B B4GALT5 FUT3 CHST10 ST8SIA6 CHST8 ST6GAL1 B4GALT2 B4GALT3 ST8SIA2 B4GALT1 MGAT5 ST8SIA3 MGAT3 FUT8 MGAT2 COPI-DEPENDENT GOLGI-TO-ER RETROGRADE TRAFFIC%REACTOME%R-HSA-6811434.1 COPI-dependent Golgi-to-ER retrograde traffic NBAS RAB1B STX18 KIF3A BNIP1 ARCN1 KIF26A KIF26B COPG2 NSF COPG1 ARF4 ZW10 KIF5B KIF5A KIF18A NAPA KIF2A KIF2C KIF2B NAPB NAPG GBF1 KDELR1 CENPE KIF21A KIF21B KIFAP3 RINT1 KIF16B KDELR2 KIF20A KIF20B COPB2 COPA TMED10 COPB1 KLC1 KLC4 KLC3 KLC2 KIF3B KIF3C SURF4 KIF18B KIF4B KIF4A COPE KIF11 USE1 TMED2 KIF15 KIF19 KIF13B TMED3 KIF1C KIF1B KIF1A TMED7 TMED9 KIF25 COPZ2 RACGAP1 ARF3 KIF23 ARF1 KIF22 ARFGAP3 KIF6 ARFGAP1 KIF27 COPZ1 ARFGAP2 KIF9 KIFC2 KIFC1 SEC22B ARF5 KDELR3 RAB1A ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12%REACTOME%R-HSA-392170.2 ADP signalling through P2Y purinoceptor 12 GNG11 GNG13 GNB2 GNAI3 GNAT3 GNAI1 GNB1 GNAI2 GNB4 GNB3 GNG3 GNG2 GNG5 GNB5 GNG4 GNG7 GNG8 GNGT1 GNGT2 P2RY12 GNG10 GNG12 GRB2 EVENTS IN ERBB2 SIGNALING%REACTOME%R-HSA-1963640.3 GRB2 events in ERBB2 signaling HRAS NRG1 NRG2 BTC NRG3 NRG4 NRAS HBEGF EREG EGF EGFR SOS1 ERBB2 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC%REACTOME%R-HSA-389957.2 Prefoldin mediated transfer of substrate to CCT TriC CCT6A TUBA1C TUBA1A ACTB CCT3 CCT2 VBP1 TUBB2B TUBB2A TCP1 PFDN1 PFDN2 PFDN4 PFDN5 PFDN6 CCT6B TUBB6 TUBB3 TUBB1 CCT8 CCT7 CCT5 CCT4 TUBA4A TUBB4B TUBB4A REGULATION BY TREX1%REACTOME%R-HSA-3248023.1 Regulation by TREX1 TREX1 FORMATION OF EDITOSOMES BY ADAR PROTEINS%REACTOME%R-HSA-77042.2 Formation of editosomes by ADAR proteins ADAR ADARB1 REGULATION OF CYTOSKELETAL REMODELING AND CELL SPREADING BY IPP COMPLEX COMPONENTS%REACTOME DATABASE ID RELEASE 72%446388 Regulation of cytoskeletal remodeling and cell spreading by IPP complex components PARVB PXN RSU1 LIMS1 ARHGEF6 ACTN1 TESK1 DEFECTIVE GALNT3 CAUSES FAMILIAL HYPERPHOSPHATEMIC TUMORAL CALCINOSIS (HFTC)%REACTOME DATABASE ID RELEASE 72%5083625 Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC) MUC1 MUC7 MUC12 MUC20 MUC4 MUC13 MUC6 GALNT3 MUC15 MUC17 MUC5B MUC21 MUCL1 MUC3A MUC5AC ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION%REACTOME DATABASE ID RELEASE 72%400042 Adrenaline,noradrenaline inhibits insulin secretion GNG11 GNG13 GNB2 GNB1 GNB4 GNB3 GNB5 GNGT1 ADRA2C ADRA2A GNGT2 CACNA2D2 ADCY6 ADCY5 CACNA1D CACNA1C CACNB2 CACNB3 GNAI1 GNAI2 GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 GNG10 GNG12 MUSCARINIC ACETYLCHOLINE RECEPTORS%REACTOME%R-HSA-390648.1 Muscarinic acetylcholine receptors CHRM3 CHRM1 CHRM2 CHRM4 CHRM5 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS%REACTOME DATABASE ID RELEASE 72%2173789 TGF-beta receptor signaling activates SMADs PPP1CC PMEPA1 NEDD8 BAMBI STRAP MTMR4 NEDD4L CBL SMAD2 SMAD3 UBA52 PPP1R15A PPP1CB SMAD7 UBE2M UCHL5 USP15 TGFB1 SMAD4 SMURF1 SMURF2 TGFBR1 UBB TGFBR2 FKBP1A UBC STUB1 RPS27A XPO1 FURIN PPP1CA CTLA4 INHIBITORY SIGNALING%REACTOME%R-HSA-389513.1 CTLA4 inhibitory signaling CD80 PPP2CA PPP2CB AKT1 LYN PPP2R5B PPP2R5A YES1 PPP2R5D PTPN11 CTLA4 PPP2R5C AKT2 PPP2R1B AKT3 PPP2R1A FYN CD86 PPP2R5E LCK PROTEIN METHYLATION%REACTOME%R-HSA-8876725.2 Protein methylation METTL10 ETFB METTL22 METTL20 N6AMT2 EEF2KMT KIN CAMKMT PRMT3 HSPA8 VCP EEF1A1 METTL21A VCPKMT RPS2 EEF2 IRAK4 DEFICIENCY (TLR2 4)%REACTOME DATABASE ID RELEASE 72%5603041 IRAK4 deficiency (TLR2 4) BTK CD36 IRAK4 TIRAP TLR1 LY96 CD14 TLR6 TLR4 MYD88 TLR2 LYSOSOME VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 72%432720 Lysosome Vesicle Biogenesis M6PR AP4B1 CHMP2A VAMP2 HGS APP CTSZ AP4E1 ARRB1 AP4M1 AP1G2 SH3GL2 VAMP8 AP1G1 VAMP7 DNAJC6 AP1S2 DNASE2 AP1B1 AP1S1 CLTC AP1S3 DNM2 ARF1 CLTB CLTA AP1M2 AP1M1 BLOC1S1 CLVS2 GNS HSPA8 AP4S1 TXNDC5 CLVS1 NONCANONICAL ACTIVATION OF NOTCH3%REACTOME%R-HSA-9017802.1 Noncanonical activation of NOTCH3 NCSTN APH1B PSENEN PSEN2 PSEN1 NOTCH3 YBX1 APH1A ACTIVATED NTRK3 SIGNALS THROUGH PLCG1%REACTOME%R-HSA-9034793.1 Activated NTRK3 signals through PLCG1 PLCG1 NTF3 NTRK3 DEFECTIVE CHST3 CAUSES SEDCJD%REACTOME DATABASE ID RELEASE 72%3595172 Defective CHST3 causes SEDCJD NCAN CHST3 BGN CSPG5 CSPG4 DCN BCAN VCAN RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION%REACTOME%R-HSA-749476.2 RNA Polymerase III Abortive And Retractive Initiation POLR2E POLR2F POLR2H GTF3C1 GTF3C2 GTF3C3 GTF3C4 POLR2K GTF3C5 POLR2L GTF3C6 SNAPC5 SNAPC1 SNAPC2 SNAPC3 SNAPC4 ZNF143 BRF2 BRF1 GTF3A BDP1 TBP CRCP SSB NFIX NFIA NFIB POLR1C NFIC POLR3GL POLR3A POLR3B POLR3C POLR3D POU2F1 POLR3E POLR3F POLR3G POLR3H POLR3K TRANSPORT OF SMALL MOLECULES%REACTOME%R-HSA-382551.5 Transport of small molecules CUL1 PRKAR2B PRKAR2A GNAS ADCY4 ADCY3 TFRC ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 FTH1 FTL LCN9 SLC35B4 LCN15 LCN12 SLCO2B1 APOD RAB11A SLC5A6 SLC16A2 SLC35A2 SLC5A8 SLC35A1 ABCG8 SLC35A3 ABCG5 SLC35C1 SLC33A1 SLCO1C1 ARL2BP SLCO4A1 SLCO4C1 SLCO2A1 LCN1 SLC27A6 SLC29A4 AVP SLC28A2 ABCB1 SLC29A1 SLC28A1 SLC29A3 ABCB7 SLC28A3 ABCB4 SLC29A2 SLC27A4 SLC44A5 SLC44A3 SLC44A4 SLC44A1 SLC44A2 ABCA3 SLC5A5 SLC34A3 SLC34A2 GPIHBP1 SLC34A1 ABCA1 FURIN PCSK6 PCSK5 SLC39A10 SLC39A14 SLC39A6 SLC39A5 SLC39A8 RHCG RHBG SLC39A7 SLC39A2 SLC39A1 SLC39A4 SLC39A3 SLC16A1 A2M SLC16A8 SLC16A3 SLC30A7 SLC30A6 SLC30A8 ARL2 SLC30A3 SLC9A1 GNG10 SLC30A2 SLCO1B1 SLC30A5 SLCO1B3 SLC30A1 GNG12 GNG11 GNG13 GNB2 GNB1 SLCO1A2 GNB4 GNB3 GNB5 FBXL5 GNGT1 GNGT2 GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 CFTR SLC2A8 RHAG PRKACG PRKACA PRKACB SAR1B SLC2A14 SLC45A3 SLC2A11 SLC8A1 SLC2A10 SLC8A2 SLC25A10 SLC2A12 SLN SLC5A10 SLC50A1 SLC2A4 SLC5A1 SLC5A2 SLC2A6 SLC2A7 SLC5A4 SLC5A9 SLC6A3 KIAA1919 ATP1B3 ATP1B2 ATP1B1 SLC32A1 SLC17A7 FXYD4 SLC17A8 FXYD3 SLC7A5 SLC5A7 FXYD2 FXYD1 FXYD7 FXYD6 RYR1 RYR2 ATP2A3 CLTC ATP2A2 ATP2A1 CLTA RYR3 AP2A1 AP2B1 AP2A2 CLIC2 AP2S1 SLC38A1 AP2M1 TRPC1 ABCC9 TRDN ASPH SLC1A1 ATP1A4 ATP1A3 SLC1A2 ATP1A2 SLC1A3 ATP1A1 SLC27A1 SRI SLC1A6 SLC1A7 PLN SLC38A2 RUNX1 ATP2B4 ATP2B3 ATP2B2 ATP2B1 SLC8A3 FKBP1B SLC6A13 SLC6A12 SLC6A11 SGK1 SLC6A1 ABCA12 ABCA10 ABCG4 ABCB6 ABCB5 ABCB8 ABCB9 ABCA2 ABCA5 ABCA4 ERLIN1 ABCA9 ABCA7 ERLIN2 ABCA8 ABCD2 ABCD3 ABCC10 ABCC11 ABCC4 CYGB ABCC6 PEX3 DERL3 ERLEC1 MBTPS1 ABCF1 PEX19 ABCB10 MBTPS2 AHCYL2 SLC4A1 SLC4A2 SLC4A3 SLC4A4 SLC4A5 SLC26A11 SLC6A19 SLC15A1 SLC25A5 SLC25A4 SLC6A18 SLC15A2 SLC25A6 SLC6A15 SLC36A4 SLC6A14 SLC9A2 SLC9A3 SLC9A4 SLC9A5 SLC9A6 SLC9A7 SLC9A8 SLC9A9 SLC1A4 SLC1A5 CUBN SLC38A3 SLC15A3 SLC15A4 SLC38A5 SLC38A4 SLC4A10 SLC16A10 BSG SLC6A6 SLC26A7 SLC26A9 VCP SLC26A4 SLC26A3 SLC26A6 SLC7A11 SEL1L SLC7A10 DERL1 SLC36A1 CES3 DERL2 SLC36A2 RNF5 SLC7A6 CAMK2B SLC25A18 SLC7A7 OS9 CAMK2D SLC7A8 CAMK2A SLC7A9 SLC24A2 SLC24A4 SLC24A3 SLC20A2 SLC43A2 SLC20A1 APOE SLC43A1 CAMK2G SLC5A12 APOB SLC3A1 SLC7A1 SLC7A3 SLC25A26 SLC25A29 SLC17A6 SLC17A1 RNF185 SLC25A22 CTNS SLC8B1 SLC6A7 SLC4A7 SLC4A8 SLC4A9 SLC24A5 SLC6A2 SLC6A5 SLC6A9 SLC18A1 PDZD11 AVPR2 STOML2 CCDC109B PHB SPG7 PHB2 PARL AKAP1 LETM1 AFG3L2 SMDT1 C2orf47 VDAC3 VDAC2 YME1L1 PMPCB MICU3 PMPCA MICU2 SLC16A7 MICU1 EMB MCU SLC13A1 SLC13A2 SLC13A3 SLC13A4 SLC22A12 SLC2A13 SLC22A6 SLC47A2 SLC22A8 SLC47A1 SLC22A7 SLC22A11 SLC41A2 CA1 SLC5A11 SLC41A1 CA2 SLC30A10 CA4 SLC5A3 SLC13A5 SLC14A1 ALB SLC10A6 SLC14A2 SLC31A1 SLC3A2 AMN KCNJ11 EIF2S2 EIF2S1 EIF2S3 SLC46A1 ATP8A2 ATP8A1 ATP12A BEST2 SLC9C1 BEST3 SLC9C2 BEST1 VDAC1 HMOX1 BEST4 ATP11C ATP11B ATP11A HMOX2 TRPC4AP SLC9B1 SLC9B2 SCNN1G SCNN1D SCNN1B SCNN1A TTYH3 TTYH2 CLCNKB WNK4 NEDD4L CLCNKA NALCN TRPM1 TRPM2 ASIC4 ASIC5 CLCA2 CLCA1 TRPM7 TRPM8 ASIC2 TRPM5 ASIC3 TRPM6 CLCA4 TRPM3 ADD1 ASIC1 TRPM4 ATP8B4 ATP8B3 ATP8B2 ATP8B1 ANGPTL4 TRPV2 TRPV3 TRPV1 ATP4B ATP4A TRPV6 WNK1 TRPV4 WNK2 TUSC3 TRPV5 LDLR WNK3 CUTC UNC80 ATP7B NR1H2 ATP7A TRPC5 TRPC4 TSC22D3 SLC22A4 ANO8 RSC1A1 ANO9 NR1H3 SLC22A15 ANO6 ABCA6 SLC22A16 ANO7 SLC22A18 ANO4 ANO5 ATP6V0D1 ANO2 ANO3 ANO1 SGK3 SGK2 STOML3 ATP10D ATP10B ATP10A RAF1 ATP2C2 ATP2C1 CLCN3 CLCN2 CLCN1 BSND STOM ANO10 ATP9B ATP9A SLC17A3 MCOLN3 SLC26A2 TRPA1 SLC26A1 ATP13A1 WWP1 MCOLN2 TPCN2 TPCN1 ABCG2 CLCN7 CLCN6 CLCN5 SLC2A9 CLCN4 OSTM1 SLC11A1 ATP13A4 ATP13A5 ATP13A2 UNC79 SLC2A1 SLC2A2 SLC2A3 HFE HBB SLC40A1 TCIRG1 MAGT1 APOA2 HEPH APOA1 SLC22A17 ATP6V1E1 APOA4 ATP6V1E2 APOA5 ATP6V1G1 ATP6V0B ATP6V0E1 ATP6V1G2 ABCD1 ATP6AP1 GLRX3 SLC24A1 SLC11A2 TFR2 ABCC3 ABCC1 ATP6V1B2 STEAP2 ATP6V0C ABCC2 ATP6V0D2 ATP6V1B1 ATP6V1A ABCC5 IREB2 NEDD8 CAND1 FTMT ATP6V0A2 ATP6V1H ATP6V0A4 ATP6V0E2 ATP6V1G3 ATP6V1D ATP6V1C1 ATP6V1F ATP6V0A1 APOC3 ATP6V1C2 CYBRD1 MCOLN1 CP TF LCN2 ACO1 APOC2 SLC35B3 SLC35B2 SLC17A5 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 TRPC7 PSMD1 TRPC6 TRPC3 SLC22A3 SLC22A5 SLC35D1 SLC22A2 PSMA5 PSMA6 PSMA3 SLC22A1 PSMA4 PSMA1 SLC18A2 SLC35D2 PSMA2 PSME3 PSME4 PSME1 PSME2 UBA52 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 UBB PSMB3 SLC6A20 UBC PSMB1 STEAP3 PSMF1 RPS27A SHFM1 PSMB8 PSMB9 SLC12A2 PSMC5 SLC12A3 PSMC6 SLC12A4 HBA2 PSMC3 SLC12A5 HBA1 CYB5R2 PSMC4 SLC12A1 AQP12A CYB5R1 PSMC1 AQP8 SLC12A6 CYB5R4 PSMC2 SLC12A7 AQP10 CYB5RL AQP9 AQP6 AQP7 AQP4 AQP5 AQP2 AQP3 AQP1 MIP AQP11 HDLBP PCSK9 VLDLR ZDHHC8 LIPA LIPC CREB3L3 LIPG LDLRAP1 MYLIP LSR SOAT1 NPC1 SOAT2 NPC2 NIPA1 ANGPTL3 NIPA2 LPA DMTN ABCG1 PIP CETP MB C19orf80 NGB MTTP LPL LRRC8C LCAT LMF2 LRRC8D LMF1 LRRC8A LRRC8B APOF LRRC8E FGF21 APOC4 NIPAL4 APOBR NIPAL1 NIPAL2 NCEH1 APOC1 NIPAL3 P4HB AZGP1 ANKH RAB11FIP2 MYO5B MRS2 MMGT1 SKP1 PQLC2 ADD3 ADD2 ADCY9 PRKAR1B PRKAR1A POST-CHAPERONIN TUBULIN FOLDING PATHWAY%REACTOME DATABASE ID RELEASE 72%389977 Post-chaperonin tubulin folding pathway TUBAL3 TUBB6 TUBB3 TBCE TUBB1 TUBA3E TUBA8 TUBA1C TUBA1B TUBA4B TUBA1A TUBA4A TUBB4B TUBB4A ARL2 TUBB2B TUBB2A TBCD TBCC TBCB TBCA AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS%REACTOME%R-HSA-198693.1 AKT phosphorylates targets in the nucleus NR4A1 RPS6KB2 AKT1 CREB1 FOXO3 AKT2 AKT3 FOXO1 FOXO6 FOXO4 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE%REACTOME%R-HSA-1799339.2 SRP-dependent cotranslational protein targeting to membrane RPL26 RPL29 RPL10L RPS4X RPL10A RPL28 RPS3A RPL23A DDOST FAU RPL41 RPL3L RPL10 RPL12 RPL13A RPL11 RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL27A SEC61A2 SEC61A1 SEC61G SEC11A SEC61B SEC11C SPCS3 SPCS2 SPCS1 SRP14 RPS9 RPS7 RPS8 RPS5 RPS6 RPN2 RPSA RPN1 TRAM1 SRP54 RPS15 RPS14 SSR4 RPS17 SSR2 RPS16 SSR3 SRP9 RPS19 RPL18A SRP72 RPL36AL SRP68 SRP19 RPS18 RPLP1 RPS11 RPS10 RPLP0 RPS13 RPS12 RPLP2 RPL7A RPS27L UBA52 RPL37A RPS26 RPS25 RPS28 RPS27 RPL36A RPS29 RPS20 RPL35A RPS21 RPS24 RPS23 RPL22L1 RPS4Y2 RPS4Y1 RPS27A RPL26L1 RPL4 RPL39L RPL5 RPL30 RPL3 RPL32 RPL31 SRPR RPL34 RPL8 RPL9 RPL6 RPL7 RPL36 SSR1 RPL35 RPL38 RPL37 RPL39 RPS15A RPL21 RPL23 RPL22 SRPRB RPL24 RPL27 BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS%REACTOME DATABASE ID RELEASE 72%111453 BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members BMF PMAIP1 BCL2L11 BCL2L1 STAT3 BAD BCL2 BID BBC3 DEFECTIVE SLC1A3 CAUSES EPISODIC ATAXIA 6 (EA6)%REACTOME DATABASE ID RELEASE 72%5619062 Defective SLC1A3 causes episodic ataxia 6 (EA6) SLC1A3 NUCLEOTIDE SALVAGE%REACTOME%R-HSA-8956321.1 Nucleotide salvage HPRT1 CDA DCK DGUOK APRT UCK2 PNP UCK1 GMPR2 UPP2 UPP1 AMPD1 UCKL1 HDHD1 AMPD2 ADAL AMPD3 TK2 TYMP TK1 ADA ADK GMPR RESISTANCE OF ERBB2 KD MUTANTS TO OSIMERTINIB%REACTOME DATABASE ID RELEASE 72%9665247 Resistance of ERBB2 KD mutants to osimertinib ERBB2IP HSP90AA1 CDC37 ERBB2 TOLERANCE OF REACTIVE OXYGEN PRODUCED BY MACROPHAGES%REACTOME%R-HSA-1222387.2 Tolerance of reactive oxygen produced by macrophages STABILIZATION OF P53%REACTOME%R-HSA-69541.5 Stabilization of p53 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 UBA52 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 CDKN2A PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 UBB PSMB3 RFWD2 UBC PSMB1 PSMF1 RPS27A CHEK2 SHFM1 PSMB8 PSMB9 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 TP53 ATM MDM2 MDM4 PHF20 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE%REACTOME DATABASE ID RELEASE 72%1660517 Synthesis of PIPs at the late endosome membrane VAC14 MTMR2 MTMR7 PIK3R4 PIK3C2A MTM1 PIKFYVE FIG4 MTMR9 PIK3C3 MTMR4 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE%REACTOME%R-HSA-168188.1 Toll Like Receptor TLR6:TLR2 Cascade CUL1 MAP2K1 MAPKAPK3 UBA52 MAPK8 PPP2R1B ATF1 PPP2R1A APP ATF2 NFKBIA IKBKG ELK1 RELA RPS6KA3 RPS6KA5 RPS6KA2 RPS6KA1 DUSP4 PPP2R5D MEF2A MEF2C IRAK3 DUSP3 TIRAP TLR1 FOS SIGIRR VRK3 TLR6 UBB TLR2 DUSP6 DUSP7 UBC CREB1 MAPKAPK2 RPS27A MAPK7 MAPK1 MAPK3 PPP2CA HMGB1 PPP2CB IKBKB NKIRAS1 NKIRAS2 MAPK14 MAP3K8 MAP2K3 CHUK MAPK11 MAP2K4 RIPK2 IRAK4 PELI1 UBE2N UBE2V1 PELI3 PELI2 NOD1 NFKB1 NOD2 NFKB2 AGER MAPK9 IRAK1 MAP2K6 S100A12 MAP2K7 MAP3K1 CD36 S100B MAPK10 TNIP2 JUN SAA1 MYD88 NFKBIB FBXW11 SOCS1 BTRC ECSIT SKP1 BTK IRAK2 TRAF6 TAB3 LY96 TAB2 TAB1 MAP3K7 CD14 TLR4 GENERIC TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 72%212436 Generic Transcription Pathway CUL1 MEN1 GLI3 GLI2 ITCH ZNF350 BMI1 RNF2 TRIM28 CTSV CBX8 PHC2 CTSL PHC1 RING1 CTSK CBX4 CBX2 PCGF2 PHC3 FOXO1 CTDP1 SUPT4H1 SUPT5H GTF2F1 GTF2F2 POLR2A POLR2B POLR2C FOXO3 POLR2D POLR2G NELFB NELFA NELFCD POLR2I POLR2J NELFE PPARGC1A PPARGC1B KIT ESR2 OPRK1 IHH KRAS SOX2 AR SOX9 RORA RSPO3 RB1 MYC CDKN2B SKP2 MAX FKBP5 CDC7 TCF7 EGFR LEF1 CEBPB TCF7L1 E2F5 NOP2 E2F6 HSPD1 ZFHX3 TGFB1 SMARCB1 RXRG SMAD4 SMURF1 HDAC10 RUNX3 EPC1 SMARCC1 SMARCC2 VENTX VEGFA SETD1B SETD1A BLM SMARCA2 PCNA SMARCA4 CBX6 RPA1 RPA2 WRN RPA3 DNA2 ASH2L PRMT6 CCNC PBRM1 ACTL6B RELA TNFRSF18 YEATS4 TFAP2B CCND1 ARID2 KMT2E KMT2D KMT2A KMT2C KMT2B TCF7L2 ESR1 KCTD6 NFKB1 KLF4 CDK4 NOTCH2 NOTCH3 KDM5B NOTCH4 ZNF287 DPY30 ZNF17 ZNF18 WDR5 ZNF285 ZNF19 ZNF282 ZNF10 ZNF12 ZNF14 RXRB ZNF28 RXRA PRR5 ARID1A ZNF274 ARID1B ZNF273 ZNF20 ZNF23 SMARCD1 ZNF25 ZNF26 SMARCD2 ZNF268 ZNF267 HDAC8 ZNF266 RBBP5 ZNF264 SMARCE1 ZNF263 ZNF34 ZNF30 AKT2 ZNF257 AKT3 ZNF256 MYB ZNF496 MLST8 PGR ZNF254 GATA3 ZNF253 ZNF493 ZNF492 ZNF250 AXIN1 UCMA CITED1 ZNF490 PRKCB ZNF43 PDPK1 ZNF45 ZNF41 ZNF248 ZNF486 ZNF485 L3MBTL2 ZNF484 UXT ZNF483 YAF2 ZNF480 PCGF6 ZNF479 CBX5 ZNF235 MGA ZNF234 RYBP ZNF233 WWOX ZNF230 TFAP2D ZNF471 TFAP2E ZNF470 CCND3 MAPKAP1 CITED4 HTT CCND2 ZNF227 CDK6 ZNF468 ZNF226 ZNF225 ZNF224 ZNF223 ZNF222 ZNF461 ZNF460 RICTOR ATAD2 ZNF77 ZNF79 ZNF70 ZNF71 ZNF74 ZNF699 ZNF215 ZNF214 VDR ZNF697 ZNF213 CAV1 ZNF454 ZNF696 MTOR ZNF212 ZNF211 ZNF692 ZNF691 ZNF208 ZNF205 ZNF689 CTNNB1 ZNF446 ZNF688 ZNF445 ZNF202 ZNF443 ZNF442 ZNF200 ZNF684 ZNF441 ZNF440 ZNF682 ZNF681 ZNF680 ZFP69B MAF ZNF439 ZNF679 ZNF436 ZNF678 ZNF473 ZNF677 ZNF676 ZNF433 ZNF675 ZNF432 PVALB ZNF431 ZNF430 ZNF671 ZNF670 DLX5 DLX6 MOBP INS ZKSCAN7 ZNF429 ZKSCAN8 ZKSCAN3 ZNF669 FAS ZNF426 TNFRSF10B ZNF668 FASLG ZNF425 ZKSCAN5 TNFRSF10A ZNF667 ZKSCAN4 ITGA4 ZNF665 ZNF664 ZKSCAN1 ZNF662 ZNF660 ZNF419 ZNF418 ZNF417 ZNF416 ZNF658 ZNF415 SP7 ZNF655 ZNF649 DGCR8 NKX3-2 ZNF641 HAND2 PPM1D ZNF627 ZNF626 ZNF625 ZNF624 MED1 ZNF621 ZNF620 ZNF860 ZNF619 ZNF616 ZNF615 MED8 ZNF614 ZNF613 ZNF611 MED4 ZNF610 MED6 ZNF729 MED7 ZNF727 ZNF726 ZNF721 ZNF720 ZFP1 ZFP2 ZNF716 BCL2L11 ZNF713 ZNF711 ZNF710 KCTD15 ZNF324B ZNF709 ZNF708 ZNF707 ZNF706 ZNF704 ZNF703 ZNF701 HIVEP3 ZNF700 ITGBL1 ZFP14 ZNF585B ZNF585A ZFP28 PRDM7 MSX2 ZNF99 ZNF92 GPRIN1 RBM14 ZNF804B ZNF175 ZSCAN32 FOXO6 ZNF169 FOXO4 ZNF705G ZNF705D NR4A1 ZNF160 ZNF705A ZSCAN25 ZNF157 ZNF398 ZNF155 ZNF154 ZNF394 ZNF383 ZNF141 ZNF382 ZNF140 ZNF37A ZNF138 ZNF136 ZNF135 ZNF133 ZNF124 ZIK1 BRD2 ZNF724P ZNF599 ZNF114 GPS2 ZNF597 ZNF596 ZNF112 ZNF347 ZNF589 ZNF587 ZNF586 ZIM2 ZNF343 ZIM3 ZNF101 ZNF584 ZNF100 ZNF583 YES1 ZNF582 IL6 ZNF33B ZNF33A ZNF337 ZNF577 ZNF334 ZNF333 ZNF331 ZNF573 ZNF571 ZNF570 ZFP30 ZNF569 ZNF568 ZNF567 ZNF324 ZNF566 ZNF565 SMAD7 ZFP37 ZNF564 ZNF563 MYL9 ZNF562 ZNF320 ZNF561 ZNF560 ZNF317 ZNF559 ZNF558 ZNF557 ZNF799 ZNF556 ZNF555 ZNF554 ZNF311 CRH ZNF552 ZNF551 ZNF793 ZNF550 DDIT3 ZNF792 ZNF791 ZNF790 KRBA1 KRBOX4 ZNF549 ZNF548 ZNF547 ZNF304 ZNF546 ZNF786 ZNF302 ZNF544 ZNF785 ESRRA ZNF543 ZNF300 ZNF782 ZNF540 ZFP69 CDK8 ZNF778 ZNF777 ZNF776 ZNF775 ZNF774 ZNF773 ZNF530 ZNF772 ZNF771 BGLAP ZNF770 TXNIP ZNF529 ZNF528 ZNF764 ZNF521 ZNF75D ZFP90 ZNF75A ZNF519 ZNF517 ZNF514 ZNF510 ZNF750 ZNF749 ZNF506 ZNF747 SMARCD3 ZNF746 ZNF500 ZNF740 ZNF738 ZNF737 ZNF736 ZNF735 ZNF732 ZNF730 ZNF607 ZNF606 ZNF605 ZNF600 ZNF839 HKR1 TWIST2 ZNF2 ZNF3 ZNF354A ZNF354C ZNF354B KCTD1 SMAD6 ZNF197 ZNF195 ZNF286A ZNF189 ZNF184 ZNF180 NOTCH1 MAML2 MAML1 HNF4G RBPJ THRB HES1 NR2C1 NR4A2 NR5A1 SNW1 MAML3 MAMLD1 THBS1 RARG RARA RARB TBL1X ITGAL RORC TBL1XR1 LGALS3 CSF1R TWIST1 RBFOX1 SLC2A3 MDC1 CCNK TP53RK MT-CO1 EHMT1 STUB1 NOC2L GLS TP53AIP1 KAT5 CHEK2 CHEK1 PIP4K2A PIP4K2B PIP4K2C TP63 DAXX PRKAB2 HUS1 PRKAB1 OPRM1 RRAGA COX7A2L SCO1 RRAGC SCO2 RRAGB DDIT4 RRAGD MT-CO2 MT-CO3 TP53 RHNO1 L3MBTL1 MEAF6 TXN PRDX2 NUAK1 BRIP1 PCBP4 PRDX1 TP53BP2 SFN ATRIP BANP BARD1 PLK3 POMC JUN PRELID1 SURF1 CREBBP CR1 CRADD GADD45A PLK2 TPX2 MOV10 AGO3 AGO4 AGO1 AGO2 RAD17 ATM CDK12 CDK13 TP73 ATR CDKN1A BTG2 COX7B CDKN1B ELL SETD8 SETD9 PHF20 PRKAG1 CHM PRKAG2 BRCA1 COX7C PRKAG3 BBC3 IL3 TAF7L RPTOR ING5 ING2 AIFM2 CASP10 TNKS1BP1 COX8A PRMT5 BRD1 RMI2 CNOT6L PRMT1 RMI1 ITGA2B TOP3A DDB2 RAD51D TCEB3CL2 COX5B COX5A PLAGL1 PERP TCEB3 PMS2 NR2E1 TCEB2 TCEB1 COL1A1 TCEB3CL TAF9B BID BRD7 TIGAR NPM1 CDKN2A MRE11A SPI1 COX6C CLDN5 MLH1 HIPK1 ZFPM1 GATA2 POU4F1 GATA1 LRPPRC NFE2 POU4F2 NFATC2 HIPK2 CTLA4 TTC5 CENPJ TAL1 YAP1 CCNG1 SERPINB13 TCEA1 PCGF5 LAMTOR2 RAD1 CSF2 LAMTOR1 LMO1 LAMTOR4 LMO2 FOXP3 LAMTOR3 SOCS4 LAMTOR5 AUTS2 STEAP3 CCNT2 IL2 CCNT1 NR4A3 TACO1 TCF3 PRDM1 LDB1 IL2RA COX6A1 STK11 SESN3 SESN2 NBN BNIP3L G6PD SUPT16H USP7 IGFBP3 USP2 TSC2 TSC1 CDC25C STAT1 COX6B1 MSH2 CCNE2 FANCD2 CCNE1 KAT6A MAPKAPK5 COX16 COX18 AK6 NDRG1 SMYD2 COX11 PMAIP1 COX14 SLC38A9 BCL2L14 MAP2K6 ZNF420 FANCI SLMO1 BRPF1 BRPF3 TNFRSF10C FANCC CNOT10 TNFRSF10D CNOT4 PPM1A CDK9 CNOT6 CNOT7 RGCC TP53I3 BCL6 CNOT11 CNOT1 RHEB CNOT2 CNOT3 JMY CDK2 MDM2 TAF4B CYCS PIN1 MDM4 CNOT8 RAD9B COX20 RAD9A YWHAE DYRK2 PPP1R13B COX4I1 PTEN TRIAP1 PIDD1 YWHAQ CASP6 PPP1R13L EXO1 CASP1 CASP2 TCEB3C TOPBP1 TCEB3B YWHAG ZNF385A YWHAH RFC5 GPX2 RFC3 RFC4 APAF1 RFC2 PPP2R5C RABGGTB RABGGTA RBL2 CCNA2 CCNA1 TFDP1 RBL1 TFDP2 RRM2B BIRC5 TMEM219 TMEM55B PRKAA1 RNF34 PRKAA2 CSNK2A1 GLS2 TAF9 TAF1L CSNK2A2 NLRC4 AURKB AURKA TP53INP1 E2F1 RBBP8 E2F4 RFFL E2F7 E2F8 CSNK2B TAF15 TAF12 TAF13 NDUFA4 TAF10 TXNRD1 MMP13 TAF11 ARID3A SSRP1 PML TNRC6C RAD50 CARM1 RQCD1 BAX TAF7 TAF6 SPP1 TAF5 TAF4 TAF3 TAF2 TNRC6A TNRC6B TAF1 FZR1 TGFA BMP2 GPAM SIRT3 SOD2 CAMK4 ANAPC15 ANAPC16 ANAPC7 UBE2C UBE2E1 UBE2D1 ANAPC10 SOCS3 ANAPC11 CCNB1 GP1BA CDC23 CDC26 CDC27 CDC16 CDK1 ANAPC4 ANAPC5 ANAPC1 ANAPC2 PF4 HDAC3 GPI PPP2R1B PPP2R1A PRKACA GRIN2A G6PC GRIN2B SERPINE1 NPPA SKIL TGIF1 TGIF2 USP9X ATP1B4 SKI TRIM33 PPP2CA MED16 PPP2CB MED15 MED17 MED12 PCK1 MED14 MED13 MED10 SATB2 GATA4 GCK MED27 NKX2-5 MED26 WWTR1 MED23 MED25 MED24 MED20 GAD1 PPARG GAD2 PPARA PPARD SUMO1 BLK ELF1 ELF2 CBFB PAX5 RUNX1 TBX5 ATF2 CHD4 EP300 JUNB MEF2C MET MED30 TCF12 FOS MED31 CREB1 SGK1 SP1 MAPK1 MAPK3 MAPK14 MAPK11 CDK5 CDK5R1 MYBL2 ERBB2 SMAD1 CAMK2B GRIA2 CAMK2D CAMK2A APOE CAMK2G TEAD4 CTGF TEAD1 TEAD2 TEAD3 IFNG UBE2I RNF111 CCNH EHMT2 RRM2 HIST1H2AE HIST1H2AD HIST3H2BB HIST1H2AC HIST1H2AB HIST1H2AJ HIST2H3A HIST1H2BF PRKCQ HIST1H2BE HIST1H2BH HIST1H2BG HIST2H3D HIST1H2BB HIST1H2BA HIST2H3C GAMT HIST1H2BD TJP1 HIST1H2BC H2AFB1 OCLN ITGA5 HIST1H3J HIST1H3A HIST1H3F PARP1 HIST1H3G ACTL6A HIST1H3H HIST1H3I HIST1H3B HIST1H3C HIST1H3D HIST1H3E H3F3B HIST1H4K CBX3 UBE2D3 HIST1H4L H3F3A H2BFS HIST1H4A CDK7 HIST1H4B CGA HIST1H4H HIST1H4I HIST1H4J HIST1H4C MNAT1 HIST1H4D HIST1H4E NR1D1 EZH2 HIST1H4F HIST2H2AA3 YY1 GSK3B HIST2H2AA4 NEDD4L CHD3 HIST2H2AC SIN3B H2AFJ SIN3A TBP EED H2AFZ NCOR2 H2AFX NCOR1 H2AFV SIRT1 HIST2H2BE ABL1 KAT2B KAT2A HIST4H4 BTG1 HIST1H2BN MSTN HIST1H2BM IGFBP1 HDAC2 SREBF1 HIST1H2BO TRIM63 NR1H2 HIST1H2BJ CAT HDAC1 FOXG1 RETN HIST1H2BI ATXN3 HIST1H2BL NPY HIST1H2BK PLXNA4 ABCA6 HIST2H4A FBXO32 PINK1 HIST2H4B CCNG2 AGRP RBBP4 POLR2E POLR2F POLR2H RBBP7 MTA2 POLR2K POLR2L MBD3 SUZ12 GTF2H1 DEK WWP1 GTF2H2 GTF2H3 GTF2H4 GATAD2B GTF2H5 GATAD2A ERCC3 ERCC2 RAD51 LBR PTPN4 IRAK1 TFAP2A TFAP2C CITED2 PITX2 YWHAB PSMD8 PSMD9 PSMD6 SRC PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 AKT1 PSMD1 TRPC3 YWHAZ PTPN11 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 SMAD2 UBA52 SMAD3 PSMD10 PSMB11 BDNF PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 SMURF2 PSMB4 PSMB5 PSMB2 UBB PSMB3 THRA RORB UBC PSMB1 NR2C2 PSMF1 HNF4A NR2C2AP RPS27A ESRRB NR2F1 NR1D2 ESRRG NR0B2 SHFM1 NRBP1 NR2F6 PSMB8 PSMB9 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 NR3C1 NFYA NFYB NFYC PTPN1 HDAC11 HEY1 HEY2 HDAC4 HDAC5 DLL1 HDAC9 HDAC6 HDAC7 JAG1 LIFR SKP1 RBX1 SST SIGNALING BY PDGF%REACTOME%R-HSA-186797.4 Signaling by PDGF RAPGEF1 PLG PDGFB PTPN12 PTPN11 CRK PIK3R2 COL4A2 COL4A1 COL6A2 COL4A4 COL6A1 COL4A3 COL9A1 CRKL STAT5A STAT5B COL6A3 COL4A5 COL9A3 BCAR1 COL6A6 COL9A2 COL6A5 PLAT THBS4 THBS3 PDGFD SPP1 STAT1 PDGFRA PIK3R1 PIK3CA PLCG1 SOS1 THBS2 THBS1 HRAS RASA1 NRAS PIK3CB STAT6 GRB7 STAT3 NCK2 SRC FURIN NCK1 PDGFRB RNA POLYMERASE II TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 72%75953 RNA Polymerase II Transcription Initiation GTF2F1 TAF2 GTF2B GTF2F2 CDK7 GTF2A1 POLR2A GTF2A2 POLR2B TAF1 POLR2C GTF2E1 POLR2D GTF2E2 POLR2G POLR2E MNAT1 POLR2F POLR2H POLR2I POLR2J AK6 POLR2K CCNH POLR2L GTF2H1 GTF2H2 GTF2H3 GTF2H4 TAF9B GTF2H5 TBP ERCC3 ERCC2 TAF9 TAF1L TAF15 TAF12 TAF13 TAF4B TAF10 TAF11 TAF7 TAF6 TAF5 TAF7L TAF4 TAF3 TRNA MODIFICATION IN THE MITOCHONDRION%REACTOME DATABASE ID RELEASE 72%6787450 tRNA modification in the mitochondrion TRMT61B MTO1 HSD17B10 TRMU TRMT10C KIAA0391 TRIT1 GTPBP3 FC EPSILON RECEPTOR (FCERI) SIGNALING%REACTOME%R-HSA-2454202.1 Fc epsilon receptor (FCERI) signaling CUL1 LAT2 PLCG2 MAPK8 RASGRP2 RASGRP1 TEC RELA IGKV1-12 IGKV2D-28 IGKV4-1 IGKV2D-30 IGHE FCER1G PPP3R1 IGKV3-11 IKBKB LYN CHUK MAP2K4 UBE2V1 NFKB1 IGKV2-28 MAPK9 MAP2K7 SYK MAP3K1 MAPK10 JUN IGKV3D-20 HRAS FBXW11 AHCYL1 NRAS PIK3CB PSMD8 PSMD9 IGKV5-2 PSMD6 GRAP2 PSMD7 PSMD4 RAC1 LCP2 PSMD5 PSMD2 VAV3 PSMD3 PDPK1 PSMD1 VAV1 VAV2 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 ITPR1 ITPR2 UBA52 ITPR3 PIK3R2 PSMD10 PSMB11 PAK1 PSMD12 PSMD11 PSMD14 NFKBIA IKBKG FYN PSMD13 PSMA7 PSMB10 PAK2 PSMA8 PRKCQ PSMB6 NFATC2 PSMB7 PSMB4 UBE2D1 PSMB5 FOS PSMB2 UBB PSMB3 CDC34 CARD11 UBC BCL10 GAB2 PSMB1 PSMF1 RPS27A ITK SHFM1 PSMB8 UBE2D2 PSMB9 MALT1 MAPK1 PSMC5 RASGRP4 PSMC6 MAPK3 PSMC3 PSMC4 PSMC1 PSMC2 UBE2N PIK3R1 PIK3CA PLCG1 SOS1 PPP3CA PPP3CB NFATC3 NFATC1 BTRC SKP1 BTK TRAF6 TAB3 TAB2 TAB1 MAP3K7 FCER1A MS4A2 TXK DEFECTIVE B3GALTL CAUSES PETERS-PLUS SYNDROME (PPS)%REACTOME%R-HSA-5083635.1 Defective B3GALTL causes Peters-plus syndrome (PpS) THSD7B ADAMTSL1 ADAMTS4 ADAMTS5 ADAMTS2 ADAMTS3 ADAMTSL4 ADAMTS1 ADAMTSL3 ADAMTSL2 THSD7A ADAMTS8 ADAMTS9 ADAMTS6 ADAMTS7 SBSPON ADAMTS20 B3GLCT CFP ADAMTS12 THBS2 THSD1 THBS1 THSD4 ADAMTS10 ADAMTS16 ADAMTS15 ADAMTS14 ADAMTS13 ADAMTS19 ADAMTS18 ADAMTS17 SEMA5A SEMA5B SPON2 SPON1 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION%REACTOME DATABASE ID RELEASE 72%450302 activated TAK1 mediates p38 MAPK activation MAPK14 MAP2K3 MAPK11 MAPKAPK3 RIPK2 UBE2N UBE2V1 NOD1 NOD2 MAPKAPK2 IRAK1 MAP2K6 IRAK2 TRAF6 TAB3 TAB2 TAB1 IKBKG MAP3K7 VXPX CARGO-TARGETING TO CILIUM%REACTOME%R-HSA-5620916.1 VxPx cargo-targeting to cilium GBF1 RHO CNGA4 CNGB1 ASAP1 EXOC8 EXOC7 RAB11FIP3 RAB3IP RAB11A EXOC4 EXOC3 EXOC6 ARF4 EXOC5 PKD2 EXOC2 PKD1 EXOC1 CNGA2 RAB8A DEPURINATION%REACTOME%R-HSA-73927.1 Depurination TINF2 NEIL3 TERF2IP HIST1H2AE HIST1H2AD HIST3H2BB HIST1H2AC ACD HIST1H2AB HIST1H2AJ HIST1H2BF HIST1H2BE HIST1H2BH HIST1H2BG HIST1H2BB HIST1H2BA HIST1H2BD OGG1 HIST1H2BC H2AFB1 HIST3H3 TERF1 TERF2 POT1 HIST1H4K HIST1H4L H2BFS HIST1H4A HIST1H4B HIST1H4H HIST1H4I HIST1H4J HIST1H4C HIST1H4D HIST1H4E MPG HIST1H4F HIST2H2AA3 HIST2H2AA4 HIST2H2AC H2AFJ H2AFZ H2AFX H2AFV HIST2H2BE HIST4H4 HIST1H2BN HIST1H2BM HIST1H2BO HIST1H2BJ HIST1H2BI HIST1H2BL HIST1H2BK HIST2H4A HIST2H4B RELEASE OF APOPTOTIC FACTORS FROM THE MITOCHONDRIA%REACTOME DATABASE ID RELEASE 72%111457 Release of apoptotic factors from the mitochondria BAK1 BAX DIABLO CYCS INHIBITION OF SIGNALING BY OVEREXPRESSED EGFR%REACTOME DATABASE ID RELEASE 72%5638303 Inhibition of Signaling by Overexpressed EGFR EGFR BTC EPGN TGFA AREG HBEGF EREG EGF DISEASES OF CARBOHYDRATE METABOLISM%REACTOME DATABASE ID RELEASE 72%5663084 Diseases of carbohydrate metabolism DCXR GALNS SI LCT IDUA RPIA GLB1 HYAL1 UBA52 G6PC3 NAGLU IDS GYG2 GYG1 G6PC PPP1R3C KHK GBE1 GYS2 GYS1 GAA UBB SGSH UBC ALDOB RPS27A EPM2A GNS HGSNAT TALDO1 GUSB ARSB NHLRC1 INFLUENZA VIRUS INDUCED APOPTOSIS%REACTOME%R-HSA-168277.5 Influenza Virus Induced Apoptosis SLC25A6 TGFB1 SIGNAL REGULATORY PROTEIN FAMILY INTERACTIONS%REACTOME%R-HSA-391160.2 Signal regulatory protein family interactions PTPN6 SIRPG CD47 PTPN11 PTK2 PTK2B TYROBP FYB SIRPB1 SIRPA SKAP2 METABOLISM OF PROTEINS%REACTOME%R-HSA-392499.7 Metabolism of proteins RAB1B CUL1 DCTN4 RPS4X GALNT2 RPS3A GALNT1 MEN1 ARCN1 CAPZA3 CAPZA1 CAPZA2 RAB18 COPG2 COPG1 ACTR10 DDX5 ZNF131 ZNF350 UHRF2 CTBP1 PARK7 BMI1 RNF2 TRIM28 NRIP1 CBX8 DDX17 PHC2 PHC1 RING1 CBX4 CBX2 PCGF2 HSPG2 MBD1 MKL1 SAFB PHC3 PPARGC1A GPIHBP1 CUL3 KBTBD7 ARF3 ARF1 RPLP1 C3 RPLP0 PRL TRMT112 GH1 RPLP2 FURIN SUMF2 SUMF1 RPS27L AR ACADVL ATF3 RPL22L1 RORA MYC SKP2 CDC25A SRD5A3 IGFBP7 SHC1 BPIFB2 CEBPB CEBPG SEMG1 ST6GALNAC6 SEC23A TGFB1 SMAD4 TGFBR1 RHOA TGFBR2 NR3C2 BLM PCNA SEC24B RPA1 SEC24A WRN CXCL8 RPL23A SEC24D SEC24C ARSA FGF23 PCSK2 PCSK1 UCN ERO1LB ERO1L KIF5C KIF5B ANPEP KIF5A FFAR4 CTSG CTSD CPA3 MME EXOC8 EXOC7 ARSJ ATP6AP2 ARSK C9orf3 ARSH PAX6 MYRIP ARSI ISL1 ARSF ACE2 ARSG EXOC4 ARSD EXOC3 EXOC6 EXOC5 ARSE EXOC2 EXOC1 ARSB CPB2 CTSA ENPEP CPB1 GRP GPR119 PLA2G7 RPL27A DPP4 TMEM27 SEC11A SEC11C TCF7L2 ACE CDX2 CMA1 MYO5A RAB27A INHBB INHBA MBOAT4 IGF1 KLF4 INHBC INHBE GZMH SPCS3 SPCS2 SPCS1 CPE REN NCOA1 INHA NCOA2 RXRA GPC3 SP100 SPHK1 L3MBTL2 CBX5 FUT3 VDR CTNNB1 MVD MAT2B INS MBTPS1 GLB1 MBTPS2 RIPK1 RPL26L1 RPL4 TRAF2 RPL5 RPL30 RPL3 RPL32 RPL31 RPL34 RPL8 RPL9 RPL6 RPL7 RPL36 RPL35 RPL38 RPL37 DCAF13 NOP58 RPL39 USP4 RPL21 RPL23 RPL22 VCP UBXN1 PRKCSH NGLY1 SEL1L DERL1 DERL2 RPL24 RNF5 APH1A RPL27 GANAB RPL26 RNF139 OS9 NCSTN MLEC RPL29 APH1B UGGT2 RPL28 UGGT1 PDIA3 EDEM3 EDEM1 AMFR EDEM2 SYVN1 MOGS MARCH6 RAD23B CYLD RNF103 OTUD7B CANX TRIM13 TNFAIP3 RPL41 CALR MAN1B1 RPL3L RNF185 ENGASE PSENEN BIRC2 BIRC3 RPL10 USP21 RPL12 RPL11 OTULIN RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 GOLGA2 AGT SMAD7 UCHL1 SENP8 UCHL3 UCHL5 USP15 FOXK2 RPS9 FOXK1 RPS7 MBD5 RPS8 MBD6 RPS5 RPS6 ADRM1 ASXL1 ASXL2 RPSA SENP5 SENP2 ASNS SENP1 ALB EIF5A2 PROZ BGLAP RPL7A EIF5A FN3K ICMT DHPS FN3KRP DOHH GGCX GAS6 ADRA2C ADRA2A RPL37A NLRP3 RPL36A FSTL3 RPL35A FOLR2 VDAC1 FUCA1 FUCA2 LYZ SERPINA1 AHSG RPL39L TFG LMAN1L LMAN2L UMOD SCFD1 CHST10 MIA2 RAB3D MIA3 ASGR1 ASGR2 CHST8 RAB44 STX17 USO1 LMAN1 LMAN2 MGAT5 MGAT3 MGAT1 TRAPPC10 SEC23IP TUSC3 FFAR1 RAB31 MANEA RAB37 TRAPPC2L TBC1D20 FUT8 TRAPPC2 ANKRD28 TRAPPC3 SEC16B RAB5B SEC16A TRAPPC5 B3GNT7 TRAPPC9 B3GNT4 TRAPPC1 CNIH1 B3GNT3 B3GNT2 TMEM115 STT3A CNIH2 CNIH3 MCFD2 RARA PPP6C PPP6R1 PPP6R3 TRAPPC6A TRAPPC6B DAD1 GORASP1 SEC22A DDOST SEC22C MGAT4C MGAT4A MGAT4B FAU FOLR1 BET1 CECR1 RAB24 RAB2A RAB10 TSPAN14 COMMD9 B4GALT2 B4GALT3 B4GALT1 USP13 MDC1 TNKS TNKS2 RNF146 MAGT1 OTUD3 CTSH QSOX1 CTSC TSHB COMMD3 DAXX RRAGA CST3 B4GALT6 TP53 B4GALT4 B4GALT5 TXN RAB9B SRP14 BARD1 ST6GALNAC1 POMC ST6GALNAC2 CMAS NPL CREBBP NANP NEU4 ST8SIA4 SLC17A5 ST8SIA5 ST3GAL5 ST8SIA6 NANS ST6GAL1 ST6GAL2 ST8SIA1 ST8SIA2 ST8SIA3 ST6GALNAC3 ST6GALNAC4 ST6GALNAC5 GNE HLA-A B2M CHM BRCA1 CKAP4 LTF ING2 DDB2 ARRB2 TCEB2 TCEB1 TAF9B NPM1 CDKN2A FN1 KLK13 HIPK2 EIF4A2 EIF4A1 UBE2L6 TRIM25 DDX58 USP7 IGFBP3 USP2 USP18 EIF4E CCNE2 CCNE1 UBE2N ANK1 GALNT11 GALNT14 GALNT13 GALNT16 GALNT15 GALNT18 GALNT10 POFUT2 WBSCR17 GYLTL1B B3GALNT2 GALNTL5 GALNTL6 B3GNTL1 GALNT9 GALNT8 EIF4EBP1 POMGNT2 EIF4B B3GNT9 B3GNT8 B3GNT6 B3GNT5 CHST4 GCNT1 GCNT3 GCNT4 GCNT7 GALNT7 GALNT6 GALNT5 GALNT4 A4GNT POMK MDM2 MDM4 PTEN RABGGTB RABGGTA CCNA2 CCNA1 BIRC5 APP ARF4 CTSZ ARRB1 CCL2 AURKB AURKA NAPA RAB5C TGOLN2 TAF10 PML RAB11A TRAF3 GBF1 SEC61A2 SEC61A1 SEC61G SEC61B GOLGB1 SLC34A2 SLC34A1 TGFA AREG SERPINC1 PROS1 KNG1 DCAF7 CCT6B TUBB6 GNAT2 FGA SERPIND1 TUBB3 GNAT3 F10 TUBB1 FBXO4 LONP2 FBXO6 GNAT1 RGS9 FGG RGS6 F2 RGS7 FBXW4 CDC34 FBXW5 F5 FBXW10 F7 FBXW7 BCL10 FBXW9 F8 TUBA4B FBXW2 PROC F9 TUBA4A XRN2 FKBP9 GNAZ ARL2 GNG10 TBCD TBCC TBCB TBCA GNG12 GNG11 GNG13 GNAO1 CCT6A GNB2 TBCE GNB1 GNB4 PDCL GNB3 SKIV2L FBXL3 GNB5 FBXL5 TUBA8 WRAP53 GNGT1 TUBA1C TUBA1B GNGT2 TUBA1A KIF13A CCT3 CCT2 VBP1 TUBB2B TUBB2A TCP1 PFDN1 PFDN2 PFDN4 PFDN5 PFDN6 HDAC3 TUBAL3 USP11 GBA GNAI3 GNAI1 GNAI2 AP3M1 TUBA3E GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 CCT8 CCT7 CCT5 CFTR CCT4 NOP56 ARFGEF2 STAT3 TUBB4B TUBB4A RGS11 EID3 SPARCL1 HRC DDA1 LRRC49 JOSD2 JOSD1 PTRH2 FSTL1 SPP2 GOLM1 TTLL7 SPSB3 TTLL6 TTLL5 TTLL4 TTLL3 TTLL2 TTLL1 CCDC8 TTLL9 TTLL8 ATXN3L CARS AGTPBP1 YARS MUL1 NAE1 DARS BMP15 WARS COMMD10 VARS SARS NSMCE4A NPPA TOP1 TARS EPRS ITIH2 FEM1C AIMP1 USP9X FEM1A NARS FEM1B AIMP2 KARS NICN1 QARS LGALS1 NSMCE2 LARS PPA1 NSMCE1 RARS MXRA8 SNX3 MARS GARS COMMD8 HLTF HARS ZBED1 IARS FARSA RCE1 RAB27B EEF1E1 CALU FARSB OTUD7A AARS IDE CHRDL1 RAB22A COMMD2 COMMD1 COMMD6 CDH2 COMMD7 COMMD4 COMMD5 RNF144A KIN ENAM MFGE8 SATB2 GATA4 STAMBPL1 PEX10 PEX12 PEX13 PEX14 VCPIP1 FAM175B MYSM1 VCPKMT PEX2 RCN1 VIMP OTUB1 OTUB2 RAB40A RAB40B RAB40C TNIP1 TNIP3 DCAF8 SMC5 SMC6 TPGS1 DCAF5 DCAF4 TPGS2 DCAF6 USP17L4 USP17L5 EVA1A USP17L8 CHGB WSB2 RNF128 SERPINA10 PRSS23 RNF152 SHPRH WDR20 KLK3 AFP KLK2 METTL21A NDNL2 SUMO1 CHML APOL1 SUMO3 SUMO2 USP17L2 UBA2 USP17L3 KTN1 SAE1 USP17L1 AGBL5 AGBL4 AGBL1 AGBL3 AGBL2 NUCB1 RAB3B RAB3C N6AMT2 RAB43 RAB42 RAB2B IGFBP5 USP5 IGFBP4 USP3 RNF40 RAB32 RAB34 RAB35 FKBP8 RAB38 STAMBP CUL9 WDTC1 AMBN TMEM132A RNF181 APC CCDC22 CYR61 METTL10 MEPE METTL22 PTP4A2 GGA3 METTL20 RAB4B TULP4 TTL RAB21 DCAF16 DCAF17 RAB20 RAB25 RAB26 RAB23 EEF2KMT RAB29 DCAF10 DCAF11 RNF20 RAB15 RAB12 RAB13 RAB19 RAB17 HSPA5 TTLL10 USP17L30 YOD1 TTLL11 TTLL12 OBSL1 DCUN1D5 DCUN1D3 DCUN1D4 DCUN1D1 DCUN1D2 SEC31A STC2 ZRANB1 RAB39B PUM2 TOP2B RANGAP1 ANKRD9 UBXN7 RAB8B RAB33A WAC FAM20C VWA1 FAM20A RAB7B USP17L27 USP17L26 USP17L29 USP17L28 USP17L21 USP17L20 USP17L22 TUBB8P12 TUBB8 USP17L25 USP17L24 USP17L15 USP17L18 USP17L17 USP17L19 USP17L10 USP17L12 USP17L11 USP17L13 RAB11B RAB9A APLP2 SHISA5 SCG3 SCG2 UBD TMEM129 AMELX SMAD1 USP37 USP47 USP48 USP49 USP42 USP44 AMTN USP14 USP16 USP12 USP19 LAMC1 USP24 USP25 USP26 USP20 USP8 USP28 NEURL2 GRIA1 LAMB2 GATA6 LAMB1 ZDHHC2 DMBT1 MUC20 LMCD1 NAPSA CCDC59 PGA3 NSF PGA5 PGA4 ADGRF5 SOCS2 CISH NAPB GOSR1 NAPG RAB41 TSPAN5 NAT8 MAN2A2 TGFBI ITM2B MAN1A2 CALB1 BACE1 MAN2A1 APCS MAN1C1 TSPAN33 GGA2 STX5 GGA1 MAN1A1 SNCA ODAM SNCAIP YKT6 SORL1 TSPAN15 COG8 COG7 CETN2 COG6 CCP110 COG5 COG4 ACTR1A COG3 COG2 RAB39A COG1 BET1L RAB33B RAB30 RAB8A RAB36 FBXW11 VDAC3 CSNK1D VDAC2 DYNLL1 DYNC1I2 DCTN2 DCTN3 HERC2 IGF2 NFRKB DYNC1H1 PRKDC COPS7B XPC COPS7A HGS BRCC3 RAB5A SPTAN1 TP53BP1 RAB7A XRCC4 INO80 SATB1 BAP1 RAD18 WDR48 GSN BABAM1 UIMC1 PARP1 ACTL6A RNF168 DDB1 UBE2D2 GPS1 UBE2D3 HIF3A CUL2 MCRS1 YY1 SPTB RUVBL1 SPTBN4 PIAS3 SPTBN5 SPTA1 SPTBN1 PIAS1 SPTBN2 UBE2V2 INO80C INO80B INO80E INO80D IFIH1 RNF135 MAVS CLSPN UBE2B COPS4 COPS3 COPS6 COPS5 UBE2T COPS2 FAM175A COPS8 UFD1L POLB ACTR5 RAD23A ACTR8 DTL USP10 TFPT RAD52 CUL4A BRE ERCC8 CUL4B RWDD3 EEF1B2 EEF1A1 EEF1G EEF1D EEF1A2 EEF2 GSK3A RHOT1 PPP2R5B SMAD2 SMAD3 LRR1 CCNF KEAP1 UBE2L3 SMURF2 FBXO7 FBXO9 WSB1 FBXO2 RFWD2 RNF123 UBE2J2 SIAH2 SIAH1 FBXL8 FBXL4 GPR75-ASB3 LRRC41 GAN KLHL2 KLHL3 UBE2G1 UBE2G2 KLHL9 SPSB2 SPSB1 KBTBD6 PCSK9 KLHL5 KBTBD8 SPSB4 CREB3L3 FBXO27 FBXO21 UBE2Z FBXO22 HDAC4 PARK2 FBXW12 HDAC7 FBXW8 UBE2E3 FBXO17 FBXO15 LMO7 FBXO10 P4HB FBXO11 KLHL41 KLHL42 KCTD7 CUL5 UBA6 TRAF6 KLHL11 KLHL13 TAB1 MAP3K7 FBXO44 FBXO41 FBXO40 BTBD1 UBE2F UBE2H KLHL25 ZBTB16 KLHL21 KLHL22 UBE2A BTBD6 FBXO30 KLHL20 FBXO31 UBE2W UBE2S UBA1 UBE2K KBTBD13 UBE2Q2 UBE2R2 ASB13 ASB14 ASB11 RNF7 ASB12 ASB17 ASB18 FBXL22 ASB15 ASB16 FBXL20 SLC35A1 ASB10 SLC35C1 FBXL19 FBXL15 FBXL16 FBXL13 FBXL14 FBXL12 ASB8 ASB9 ASB6 ASB7 ASB4 ASB5 ASB2 ASB1 ABCA3 DPAGT1 MPI ALG8 ALG9 ALG6 ALG14 ALG3 ALG13 ALG12 ALG1 ALG11 DHDDS MPDU1 NUS1 PMM2 DOLK RFT1 MGAT2 WDR61 LEO1 TNC TRAPPC4 USP34 CDC73 AXIN2 OTUD5 APEH TRRAP HCFC1 CTR9 RTF1 PAF1 TADA2B HIST2H2AB UBA3 PRMT3 SOCS6 UBE2M HIST2H2BF RELA HIST3H2A KDM1B TFAP2B MITF FOXL2 HIC1 HIST1H2AG SP3 HIST1H2AA HIST1H2AM HIST1H2AL HIST1H2AI HIST1H2AH HIST1H2AK ATXN7 ESR1 KCTD6 NFKB2 TADA3 OGT WDR5 TMED2 RAB6A RBBP5 USP22 PGR GATA3 AXIN1 FOXO4 IAPP CALCA ADRB2 CRHR2 IL6 FSHB TOMM20 GIP ADORA2A ADORA2B DDIT3 ATF6 HSP90B1 ATF4 USP30 BECN1 TOMM70A EIF1AX EIF2B5 EIF2B4 EIF2B3 EIF2B2 EIF2S2 EIF2S1 EIF5 EIF2S3 EIF2B1 NOTUM EIF5B EIF4H EIF3M EIF3K EIF3L EIF3I EIF3J EIF3G EIF3H EIF3E EIF3F EIF3C EIF3D EIF3A EIF3B POMT2 GALNT12 SEMA5A SEMA5B SPON2 SPON1 THSD7B POMT1 ADAMTSL1 ADAMTS4 ADAMTS5 ADAMTS2 C1GALT1C1 ADAMTS3 THRB ADAMTSL4 NR2C1 ADAMTS1 NR4A2 ADAMTSL3 NR5A1 ADAMTSL2 MUC12 DAG1 EIF2AK3 MUC13 HERPUD1 MUC15 THSD7A PAPPA2 ADAMTS8 IGFALS ADAMTS9 ERN1 ADAMTS6 CREB3 ADAMTS7 CREB3L4 SBSPON CREB3L1 CREB3L2 MUCL1 MUC3A IGFBP2 POMGNT1 IGFBP6 MUC5AC PAPPA ADAMTS20 CUL7 KLK1 B3GLCT DCTN1 CREBRF CFP FKBP14 DCSTAMP ADAMTS12 GOSR2 THBS2 SRPR THSD1 CXXC1 ADD1 THBS1 THSD4 MYDGF ADAMTS10 EXTL2 ADAMTS16 EXTL1 ADAMTS15 SERP1 ADAMTS14 TATDN2 LMNA MUC1 ADAMTS13 DNAJB9 ADAMTS19 SSR1 ADAMTS18 EXTL3 LARGE TSPYL2 ADAMTS17 ZBTB17 KLHDC3 MUC7 MUC4 WFS1 DDX11 MUC6 GFPT1 GALNT3 MUC17 WIPI1 C1GALT1 PDIA6 YIF1A MUC5B ARFGAP1 MUC21 PDIA5 DNAJC3 CTDSP2 DNAJB11 SRPRB TPP1 PREB HDGF HYOU1 KDELR3 TLN1 ATP6V0D1 TIMP1 MSRA PCMT1 CSF1 MSRB2 MSRB3 MSRB1 SOCS5 SFTA3 SFTPB SFTPA2 SFTPC SFTPD CSF2RB SFTPA1 CSF2RA MMP1 MMP2 NEDD8 CAND1 CP TF GMPPB C4A FPGT GMPPA PGM3 GNPNAT1 NUDT14 ALG5 ALG10 RENBP ALG10B TSTA3 UAP1 FUOM GMDS AMDHD2 FUK PMM1 GFPT2 NAGK DOLPP1 CD59 CD55 RAB3A STX1A P2RY2 VAMP2 TOP2A COL7A1 SMC3 CDC20 DYNC1LI1 DYNC1LI2 CDCA8 DMP1 CSNK2A1 CSNK2A2 RAD21 STAG1 CSNK2B STAG2 SMC1A DYNLL2 INCENP MATN3 SPP1 DYNC1I1 ALPI ACHE PLA2G4B LTBP1 BMP4 FBN1 BCHE PLG PNPLA2 NFKBIA IKBKG IKBKE TOPORS TRIM27 VHL UBE2C UBE2E1 UBE2D1 SOCS3 LEP CDK1 SLC30A7 SLC30A6 SLC30A8 SLC30A5 ANK2 ANK3 NUP107 NUP188 PIGS CPM LY6K PIGU PIGT PGAP1 PIGO NUP62 PSCA PIGN GPAA1 NDC1 NUP214 PIGP SAR1B PIGZ SEC13 MSLN PIGW NUP133 PIGV USP33 NUP210 PIGY PRSS21 PIGX FCGR3B PRND TECTA NUP93 TECTB CD52 NUP50 PLAUR SULT1A3 GAPDHS RTN4RL2 NUP54 IZUMO1R ALPPL2 PIGC DPM1 DPM2 PIGB DPM3 NRN1L CEACAM7 RTN4RL1 B4GAT1 CD109 PIGA CEACAM5 LY6D POM121 NUP205 PIGK SPACA4 PIGM AAAS PIGL LY6H NUP160 PIGG PIGF NUP85 GPLD1 LY6E TPR PIGH NRN1 NUP88 MFI2 NUP43 NTM TEX101 LYPD1 RAE1 LYPD2 LYPD3 RANBP2 THY1 LYPD4 LYPD5 NUP155 ART3 ART4 OTOA LY6G6C NUP153 LY6G6D OPCML NTNG1 NTNG2 NEGR1 CNTN5 GP2 LSAMP PLET1 NUP35 VNN3 NUPL2 PARS2 XPNPEP2 RAET1G EARS2 LARS2 LYPD6B NUP37 TARS2 RAET1L AARS2 ALPL CNTN3 RPN2 CNTN4 RPN1 HARS2 ULBP2 MDGA2 TRAM1 GFM2 MDGA1 RECK SRP54 PPARG SPRN FARS2 SSR4 PPARA ALG2 SSR2 SSR3 SRP9 MRRF SRP72 SRP68 SRP19 MTFMT YARS2 NARS2 RARS2 CARS2 VARS2 MARS2 DARS2 SARS2 MTRF1L MTIF2 MTIF3 IARS2 WARS2 STAM PIAS4 STAM2 DPH1 DPH2 EP300 DPH3 DPH5 DPH6 DPH7 VGF ETFB VCAN STS MRPS17 MRPS15 GFM1 MRPS16 MRPS14 PPA2 MRPS11 MRPS12 MRPL38 CES1 MRPS10 MRPL39 MRPL36 SDC2 MRPL37 MRPL34 NEU2 MRPL35 NEU3 MRPL32 MRPL33 MRPL4 NEU1 MRPL41 MRPL3 APOE MRPL42 APOB MRPL2 MRPL1 B4GALNT2 MRPL40 MRPL9 CHCHD1 MRPS28 TSFM BST1 MRPS26 MRPS27 MRPS24 MRPS25 MRPS22 MRPS23 MRPL49 MRPS18B MRPS2 MRPS18A MRPL47 MRPL48 MRPL45 MRPS7 MRPL46 MRPS6 MRPS5 MRPL43 MRPS18C TUFM MRPL44 MRPL52 OXA1L MRPL53 MRPL50 MRPS9 MRPL51 AURKAIP1 DAP3 MRPS35 MRPS36 MRPL18 MRPS33 MRPL19 MRPS34 MRPL16 MRPS31 MRPL17 MRPL14 MRPL15 MRPS30 MRPL12 GCG MRPL57 MRPL13 MRPL10 MRPL54 MRPL55 MRPL11 MRPL20 ICT1 GADD45GIP1 PTCD3 MRPL27 HNRNPK MRPL28 ERAL1 HNRNPC MRPL23 MRPL24 MRPL21 MRPL22 MRPL30 UBE2I TTF1 ACTB HIST1H2AE HIST1H2AD HIST3H2BB HIST1H2AC HIST1H2AB HIST1H2AJ HIST2H3A HIST1H2BF HIST1H2BE HIST1H2BH HIST1H2BG HIST2H3D HIST1H2BB HIST1H2BA HIST2H3C HIST1H2BD HIST1H2BC H2AFB1 DNMT1 HIST1H3J HIST1H3A HIST1H3F HIST1H3G HIST1H3H RPS4Y2 HIST1H3I RPS4Y1 SUDS3 HIST1H3B HIST1H3C HIST1H3D HIST1H3E H3F3B HIST1H4K HIST1H4L H3F3A H2BFS ST3GAL4 HIST1H4A ST3GAL6 HIST1H4B CGA HIST1H4H ST3GAL1 HIST1H4I HIST1H4J ST3GAL2 HIST1H4C ST3GAL3 HIST1H4D HIST1H4E HIST1H4F HIST2H2AA3 HIST2H2AA4 CHD3 HIST2H2AC SIN3A DNMT3B H2AFZ NCOR2 DNMT3A H2AFX HIST2H2BE KAT2B KAT2A HIST4H4 RPS15A HIST1H2BN HIST1H2BM HDAC2 IGFBP1 HIST1H2BO NR1H2 HIST1H2BJ HDAC1 HIST1H2BI HIST1H2BL ATXN3 ANO8 HIST1H2BK HIST2H4A FBXO32 HIST2H4B MTA1 N6AMT1 TDG RPL10L RPL10A RBBP7 SUZ12 RAB4A IL33 APOA2 APOA1 RPL13A APOA4 APOA5 TTR RIPK2 NOD1 NOD2 RAB14 TNIP2 SAA1 TFAP2C RPS15 RPS14 RPS17 RPS16 FBXL7 RPS19 RPL18A RPL36AL RPS18 FBXL18 RPS11 RPS10 RPS13 PSMD8 RPS12 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 KHSRP PSMD3 ADAM10 PSMD1 DIS3 PSMA5 PSMA6 PSMA3 LHB PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 PABPC1 UBA52 DCP2 RPS26 PSMD10 PSMB11 RPS25 PSMD12 RPS28 GSPT2 PSMD11 GSPT1 RPS27 PSMD14 VNN1 VNN2 PSMD13 RPS29 PARN PSMA7 PSMB10 RPS20 RPS21 PSMA8 RPS24 RPS23 EXOSC7 PSMB6 ETF1 EXOSC6 PSMB7 EXOSC5 PSMB4 EXOSC4 PSMB5 PSMB2 UBB PSMB3 EXOSC9 EXOSC8 UBC PSMB1 PSMF1 EXOSC3 RPS27A EXOSC2 EXOSC1 HSPA8 SHFM1 PSMB8 PSMB9 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 NR3C1 PSMC2 EIF4G1 KDELR1 NFYA NFYB NFYC KDELR2 EPAS1 COPB2 HIF1A COPA TMED10 COPB1 PENK RAB6B COPE CAPZB TMED3 TMED7 TMED9 COPZ2 ARFGAP3 CAMKMT COPZ1 ARFGAP2 BTRC SKP1 RBX1 SEC22B ARF5 DCTN6 RAB1A DCTN5 RELEASE OF HH-NP FROM THE SECRETING CELL%REACTOME%R-HSA-5362798.1 Release of Hh-Np from the secreting cell NOTUM DISP2 SCUBE2 SHH DHH ADAM17 IHH GPC5 SYNTHESIS OF DOLICHYL-PHOSPHATE-GLUCOSE%REACTOME DATABASE ID RELEASE 72%480985 Synthesis of dolichyl-phosphate-glucose NUDT14 ALG5 PDE3B SIGNALLING%REACTOME%R-HSA-165160.3 PDE3B signalling AKT2 PDE3B SODIUM PROTON EXCHANGERS%REACTOME DATABASE ID RELEASE 72%425986 Sodium Proton exchangers SLC9A2 SLC9A3 SLC9A4 SLC9A5 SLC9A6 SLC9A7 SLC9A8 SLC9A1 SLC9A9 ANDROGEN BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 72%193048 Androgen biosynthesis SRD5A1 HSD17B12 SRD5A3 CGA CYP17A1 HSD3B2 HSD3B1 POMC LHB HSD17B3 SRD5A2 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1%REACTOME%R-HSA-1810476.2 RIP-mediated NFkB activation via ZBP1 IKBKB NKIRAS1 NKIRAS2 CHUK ZBP1 RIPK3 DHX9 NFKB1 NFKB2 RIPK1 TICAM1 NFKBIA IKBKG TLR3 MYD88 RELA NFKBIB RRNA PROCESSING%REACTOME%R-HSA-72312.3 rRNA processing RPL26 WBSCR22 RPL29 MPHOSPH10 RPS4X RPL28 NOL11 NOL12 RPS3A NAT10 UTP14A UTP14C RPL41 HEATR1 NOL9 NOL6 RPL3L PES1 BOP1 MPHOSPH6 RPP30 FBL RPP38 DIMT1 UTP11L RPP21 RPP25 EMG1 UTP20 RPP40 RCL1 RBM28 DDX49 DDX47 UTP15 DDX52 SENP3 UTP18 BMS1 RPL10 RPP14 RPL12 RPL11 RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPS9 RPS7 NHP2L1 RPS8 RPS5 RPS6 RPSA SKIV2L2 CSNK1D CSNK1E RPLP1 RPLP0 TRMT112 TFB1M RPLP2 RPL7A RPS27L RPL37A RPL36A RPL35A RPL22L1 RPS4Y2 RPS4Y1 XRN2 RPL39L NOP2 RPS15A HSD17B10 NOP56 DDX21 RPL10L RPL10A RPL23A FAU DKC1 NHP2 GAR1 NOP10 RPL13A NSUN4 RNMTL1 MTERF4 RPL27A FTSJ2 MRM1 RPS15 RPS14 RPS17 RPS16 RPS19 RPL18A RPL36AL RPS18 RPS11 RPS10 RPS13 RPS12 DIS3 UBA52 RPS26 RPS25 RPS28 RPS27 RPS29 RPS20 RPS21 RPS24 RPS23 EXOSC7 EXOSC6 RRP1 EXOSC5 EXOSC4 RRP9 WDR75 EXOSC9 EXOSC8 RRP7A PNO1 TBL3 EXOSC3 LAS1L RPS27A EXOSC2 WDR46 EXOSC1 WDR43 RIOK2 RIOK1 WDR36 TEX10 DIEXF GNL3 NIP7 PELP1 TSR3 NOC4L EXOSC10 TRMT10C RRP36 ELAC2 KIAA0391 UTP6 UTP3 RIOK3 WDR18 WDR12 BYSL TSR1 RPL26L1 RPL4 RPL5 RPL30 FTSJ3 RPL3 EBNA1BP2 RPL32 NCL RPL31 ISG20L2 RPL34 NOP14 RPL8 RPL9 WDR3 RPL6 RPL7 NOB1 RPL36 C1D RPL35 RPL38 RPL37 DCAF13 RPL39 NOP58 KRR1 RPL21 LTV1 RPL23 FCF1 RPL22 THUMPD1 PWP2 IMP3 IMP4 CIRH1A RPL24 PDCD11 RPL27 ERI1 DHX37 HH MUTANTS ABROGATE LIGAND SECRETION%REACTOME DATABASE ID RELEASE 72%5387390 Hh mutants abrogate ligand secretion PSMD3 OS9 PSMD1 PSMA5 PSMA6 PSMA3 SYVN1 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 UBA52 PSMD10 PSMB11 PSMD12 HHAT SHH PSMD11 PSMD14 DHH IHH PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 UBB PSMB3 UBC PSMB1 PSMF1 RPS27A SHFM1 PSMB8 PSMB9 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 ERLEC1 PSMD8 VCP PSMD9 PSMD6 PSMD7 SEL1L PSMD4 PSMD5 DERL2 PSMD2 NEIL3-MEDIATED RESOLUTION OF ICLS%REACTOME%R-HSA-9636003.1 NEIL3-mediated resolution of ICLs NEIL3 DEFECTIVE CHSY1 CAUSES TPBS%REACTOME%R-HSA-3595177.1 Defective CHSY1 causes TPBS NCAN BGN CSPG5 CSPG4 DCN CHSY1 BCAN VCAN TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM%REACTOME DATABASE ID RELEASE 72%72202 Transport of Mature Transcript to Cytoplasm NUP107 NUP188 CPSF4 CPSF1 SLBP CPSF3 CPSF2 WDR33 NUP62 FIP1L1 NDC1 NUP214 SEC13 SYMPK NUP133 NUP210 NUP93 NUP50 NUP54 POM121 NUP205 NCBP1 NXT1 NCBP2 EIF4A3 AAAS CASC3 NUP160 GLE1 MAGOH THOC1 NUP85 THOC3 TPR EIF4E THOC2 THOC5 NUP88 THOC7 NUP43 CDC40 THOC6 SRRM1 RAE1 DDX39A DDX39B RANBP2 ZC3H11A SARNP SRSF2 NUP155 SRSF3 SRSF4 SRSF5 SRSF6 SRSF7 NUP153 SLU7 SRSF9 FYTTD1 LUZP4 RBM8A POLDIP3 SRSF1 U2AF1 NUP35 U2AF1L4 NUPL2 NXF1 NXF2 U2AF2 NUP37 DHX38 SRSF11 CHTOP UPF3B MAGOHB NXF2B RNPS1 CA ACTIVATED K+ CHANNELS%REACTOME DATABASE ID RELEASE 72%1296052 Ca activated K+ channels KCNN1 KCNN2 KCNN3 KCNN4 KCNMB1 KCNMA1 KCNMB2 KCNMB3 KCNMB4 ALKBH3 MEDIATED REVERSAL OF ALKYLATION DAMAGE%REACTOME DATABASE ID RELEASE 72%112126 ALKBH3 mediated reversal of alkylation damage ASCC2 ASCC3 ASCC1 ALKBH3 P75NTR RECRUITS SIGNALLING COMPLEXES%REACTOME%R-HSA-209543.1 p75NTR recruits signalling complexes IKBKB RIPK2 NGFR UBB PRKCI UBC RPS27A UBA52 IRAK1 TRAF6 SQSTM1 MYD88 NGF PROTON OLIGOPEPTIDE COTRANSPORTERS%REACTOME DATABASE ID RELEASE 72%427975 Proton oligopeptide cotransporters SLC15A4 SLC15A2 SLC15A1 SLC15A3 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE%REACTOME%R-HSA-77075.2 RNA Pol II CTD phosphorylation and interaction with CE GTF2F1 GTF2F2 CDK7 POLR2A POLR2B RNMT POLR2C POLR2D POLR2G POLR2E RNGTT MNAT1 POLR2F POLR2H POLR2I POLR2J POLR2K CCNH POLR2L GTF2H1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 ERCC3 ERCC2 SUPT5H DEFECTIVE NTHL1 SUBSTRATE BINDING%REACTOME%R-HSA-9630222.1 Defective NTHL1 substrate binding NTHL1 DEADENYLATION-DEPENDENT MRNA DECAY%REACTOME%R-HSA-429914.2 Deadenylation-dependent mRNA decay TNKS1BP1 DIS3 DCP1B ZCCHC11 CNOT6L XRN1 PABPC1 DCP2 PARN DDX6 ZCCHC6 EXOSC7 EXOSC6 EIF4A2 EIF4A1 EXOSC5 PAN2 EXOSC4 PAN3 EXOSC9 EXOSC8 EXOSC3 EXOSC2 HBS1L EXOSC1 TTC37 WDR61 NT5C3B RQCD1 DCPS LSM5 EIF4A3 LSM4 LSM3 LSM2 DCP1A EIF4E EIF4G1 LSM7 LSM6 PAIP1 SKIV2L EDC3 EDC4 EIF4B CNOT10 CNOT4 LSM1 CNOT6 CNOT7 PATL1 CNOT11 CNOT1 CNOT2 CNOT3 CNOT8 DEGRADATION OF CYSTEINE AND HOMOCYSTEINE%REACTOME%R-HSA-1614558.6 Degradation of cysteine and homocysteine ADO CDO1 GADL1 MPST TXN2 SQRDL SLC25A10 TSTD1 GOT2 SUOX TST CTH CSAD ETHE1 METABOLIC DISORDERS OF BIOLOGICAL OXIDATION ENZYMES%REACTOME DATABASE ID RELEASE 72%5579029 Metabolic disorders of biological oxidation enzymes CYP24A1 CYP26C1 TPMT CYP2R1 MAOA GGT1 SLC35D1 UGT1A4 MAT1A FMO3 CYP11A1 POMC ACY1 CYP21A2 FDXR CYP1B1 GCLC CYP11B2 CYP11B1 GCLM AHCY CYP7B1 UGT1A1 CYP4F22 CYP17A1 CYP19A1 GSS TBXAS1 FDX1 MC2R FDX1L CYP27B1 CYP27A1 OPLAH CYP26B1 CYP2U1 DEVELOPMENTAL BIOLOGY%REACTOME DATABASE ID RELEASE 72%1266738 Developmental Biology RPS4X PRKAR2A RPS3A THRAP3 NUMB WNT10B FAM120B PCGF2 FOXO1 NCBP1 NCBP2 POLR2A POLR2B POLR2C FOXO3 POLR2D POLR2G POLR2I POLR2J UNC5A PPARGC1A UNC5B HRAS RASA1 NRAS RPLP1 RPLP0 RPLP2 FURIN PCSK6 RPS27L ABL2 CAP2 SOX2 FABP4 RPL22L1 MYC NTN4 HSP90AB1 WNT1 PIK3CD SHC1 GAB1 PI3 PIK3R1 EGFR PIK3CA LEF1 PLCG1 SOS1 CEBPB TGFB1 SMAD4 PPP3CB RHOA SMARCA4 RPL23A ASH2L CCNC FGF2 FES RELA FGF10 PIK3R3 SLC2A4 PAX6 ISL1 KMT2D RPL27A KMT2A KMT2C WASL NFKB1 KLF4 CDK4 CD36 NCOA1 NCOA2 NCOA6 NCOA3 WDR5 KDM6A RXRA LGI1 LGI4 GPC1 LGI3 LGI2 ADAM22 ADAM11 STX1B ADAM23 ITGB3 RBBP5 PIK3CB AKT2 AKT3 MYB TREM2 NCK2 ITGAV TYROBP RAC1 CXCL12 NCK1 VAV3 NCAM1 VAV2 DOCK1 ROCK1 ROCK2 CCND3 CXCR4 PIK3R2 CDC42 PAK1 CTNNA1 FYN PAK3 PAK2 JUP PTK2 MAPK12 MAPK13 CHD9 CTNNB1 INS RAP1GAP RPL26L1 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPL34 RPL8 RPL9 RPL6 RPL7 RPL36 PPL TRIO ITSN1 RPL35 RPL38 RPL37 TNF RPL39 MED1 RPL21 MAG RPL23 RPL22 MED8 NGEF MED9 MED4 MED6 PSEN2 MED7 PSEN1 KALRN RPL24 APH1A RPL27 RPL26 NCSTN RPL29 APH1B RPL28 CDK19 RPL41 RPL3L PSENEN ARHGEF11 ARHGEF12 SOS2 CNTNAP1 DCX NRCAM IAPP RPL10 RPL12 RPL11 RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 LYN MYL12A CAPNS1 YES1 MYL12B CAPN1 MYH11 ITGA1 MYL6 MYL9 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA CACNB2 CACNB3 MYH9 CDK8 RPL7A ARPC1B ARPC1A MYO9B ACTG1 RPL37A SMARCD3 ARPC4 FOXH1 ARPC5 ACVR1B ARPC2 ACVR2B RPL36A ARPC3 ACVR2A DRAP1 ACTR3 ACVR1C RPL35A ACTR2 MYO10 RET GFRA3 SHC3 SEMA5A NOTCH1 MAML2 ONECUT3 MAML1 ONECUT1 HNF4G RBPJ NEUROD1 HES1 NKX6-1 NKX2-2 NR5A1 PDX1 PAX4 HNF1B HNF1A DAG1 MAFA SNW1 RFX6 MAML3 INSM1 PTF1A MAMLD1 FOXA3 NEUROG3 FOXA2 RPL39L HOXA3 HOXA2 HOXA1 PKNOX1 HOXA4 PIAS2 DSC1 HOXB4 HOXB3 HOXB2 HOXB1 HOXD1 HOXC4 PBX1 MAFB HOXD4 HOXD3 TLN1 RARG CTCF PTPRC PAGR1 RARA RARB MAP2K1 TBL1X MEIS1 ZNF335 MAP2K2 SCD5 FAU CSF3R NFASC TBL1XR1 KRT1 CEBPD SLC2A2 CAP1 MMP2 JUN CREBBP ST8SIA4 SDCBP ST8SIA2 TCHH CDKN1A LCE1A TGM1 CASP14 LCE1B LCE5A LIPJ LIPN LIPM LIPK PRSS8 TGM5 MMP9 RPTN CELA2A KRTAP27-1 SPINK6 KRTAP5-10 SPINK5 KRTAP5-11 KAZN KRTAP16-1 LCE1E NR2F2 LCE1F KRTAP25-1 LOR KRTAP2-4 LCE1C KRTAP2-3 LCE1D ZNF467 LCE2B KRTAP2-2 LCE2C KRTAP2-1 FOXD3 LCE2A UTRN LCE6A SALL1 PKP2 KRTAP4-4 DPPA4 PKP4 KRTAP4-3 ZIC3 MBP SPINK9 SALL4 NANOG PKP3 KRTAP4-2 STX1A ITGA2B KRTAP4-1 DSG4 EPHA1 KRTAP4-9 IVL TDGF1 POU5F1 DSC2 KRTAP4-8 DSC3 KRTAP4-7 FLG KRTAP4-6 KRTAP4-5 SPRR2E ADGRV1 PERP SPRR2F ZNF638 SPRR3 KRTAP29-1 SPRR2G KRTAP6-2 TCEB2 CSTA KRTAP6-1 TCEB1 KLK5 KRTAP6-3 KLK8 EVPL KRTAP8-1 MPZ LCE2D POU3F1 LCE3C POU3F2 LCE3D COL4A2 KRTAP23-1 LCE3A ADGRG6 LCE3B COL4A1 LELP1 KRTAP12-1 COL6A2 SPI1 KRTAP12-3 SPRR2A KRTAP12-2 SPRR2B COL4A4 KRTAP12-4 SPRR2D GATA2 KRTAP10-1 ST14 KRTAP21-2 CDSN COL6A1 KLK13 KRTAP21-3 COL4A3 KLK14 HMGCR KRTAP10-3 LCE3E COL9A1 KLK12 KRTAP10-2 TAL1 YAP1 KRTAP10-5 LCE4A KRTAP10-4 SPRR1A KRTAP10-7 SPRR1B COL6A3 KRTAP10-6 COL4A5 KRTAP10-9 COL9A3 KRTAP10-8 KRTAP21-1 COL6A6 COL9A2 KRTAP17-1 SOX10 COL6A5 KRTAP4-11 KRTAP26-1 TCF3 KRTAP1-5 LDB1 KRTAP1-4 KRTAP1-3 KRTAP1-1 KRTAP15-1 KRTAP3-3 KRTAP3-2 KRTAP3-1 KRTAP5-3 KRTAP5-2 KRTAP5-1 KRTAP5-9 KRTAP5-8 KRTAP5-7 KRTAP5-6 KRTAP5-5 KRTAP5-4 KRTAP19-2 KRTAP19-1 FRS2 KRTAP19-4 NRP1 KRTAP19-3 CNTN6 KRTAP19-6 CHL1 KRTAP19-5 ITGA10 KRTAP19-8 ANK1 KRTAP19-7 KRT4 KRT3 KRT2 EBF1 KRT8 KRT7 KRT5 KRT9 MAP2K6 KRTAP20-1 KRTAP20-2 KRTAP10-10 KRTAP10-11 KRTAP10-12 KRT33B KRT33A GDF1 KRT24 ADIRF KRT23 KRT20 CNOT6 KRT28 KRT27 KRT26 PRX KRT25 KRTAP9-7 KRTAP9-6 KRTAP9-4 KRTAP9-3 KRTAP9-2 KRTAP9-1 CDK2 KRT35 KRT34 KRT32 KRT31 KRTAP9-9 KRTAP9-8 KRT39 KRT38 KRT37 KRT36 DRP2 KRT13 KRT12 KRT10 KRT19 KRT18 KRT17 KRT16 KRT15 KRT14 KRTAP24-1 KRT6C KRT6B KRT6A KRT71 KRTAP13-2 KRTAP13-1 KRTAP13-4 KRTAP13-3 KRT79 KRT78 KRT77 KRT76 KRT75 KRT74 KRT73 KRT72 KRT40 KRTAP22-1 KRTAP11-1 KRT82 TFDP1 KRT81 KRT80 TFDP2 KRT86 KRT85 KRT84 KRT83 PMP22 CSNK2A1 CSNK2A2 SH3GL2 E2F1 CSNK2B MYH14 MYH10 CARM1 RQCD1 CLASP2 LEP IRS2 VASP ENAH EVL ALCAM DPYSL4 DPYSL5 DPYSL2 DPYSL3 HDAC3 UNC5C UNC5D AGAP2 FLRT3 RDX LYPLA2 DSCAML1 ZSWIM8 FARP2 MSI1 PLXNC1 SEMA6A SEMA6D SEMA7A PLXNA2 PLXNA1 PLXNA3 DAB1 CLTCL1 LHX3 LHX2 STAT3 PLXNB3 PLXNB1 LHX4 LHX9 SEMA3A SEMA3E ABLIM1 ABLIM2 ABLIM3 SEMA4A SEMA4D RPS6KA4 EPHA5 EPHA4 EPHA7 EPHA6 DNM1 EPHA8 ANK2 DNM3 HFE2 ANK3 SHTN1 EZR EPHA3 EPHA2 EPHA10 RRAS RPS6KA6 NRP2 RGMB RGMA RELN PAK7 KCNQ2 PAK6 KCNQ3 PAK4 CD72 DSCAM PRKACG DOK4 PFN1 DOK5 PRKACA DOK6 PRKACB ARHGEF28 EFNA5 EFNA4 EFNA1 EFNA3 EFNA2 USP33 RND1 EFNB2 EFNB1 GAP43 CRMP1 EFNB3 EPHB2 PDLIM7 GRIN2B EPHB1 EPHB4 EPHB3 PIP5K1C SCN11A SCN9A SCN1B SCN1A MED19 MED16 MED15 MED18 MED17 MED12 CACNB1 SCN10A MED11 GIT1 CACNB4 PCK1 NTN3 MED14 SCN8A CDH4 MED13 CDH2 BNIP2 CTNNA2 MED10 NEO1 CDON SPAG9 MYOG MEF2B MYOD1 GCK MYF6 TCF4 CACNA1S CDH15 SCN3B MYF5 MED27 MED26 SCN3A MED29 WWTR1 MED28 MED23 MED22 MED25 MED24 MED21 MED20 SCN2A SCN2B PPARG GRIN1 PPARA CLTC CLTB CLTA AP2A1 SCN5A AP2B1 AP2A2 AP2S1 AP2M1 TRPC1 PFN2 SCN4A SCN4B AGRN CFL1 SCN7A LIMK2 LIMK1 CBFB RUNX1 ADIPOQ DLG3 NAB1 NAB2 RPS6KA3 RPS6KA5 RPS6KA2 RPS6KA1 EP300 MEF2A MEF2C MET MED30 TCF12 MED31 DNM2 CREB1 MAPK7 MAPK1 MEF2D EIF4A3 MAPK3 CASC3 EGR2 MAGOH MAPK14 MAPK11 CDK5 CDK5R1 RBM8A HSP90AA1 ERBB2 UPF3B MAGOHB RNPS1 NCAN ITGB1 GRB7 LAMC1 DOK2 ITGA2 SDC2 LAMA2 LAMA1 AKAP5 CACNG8 CACNG2 RANBP9 LAMB1 CACNG3 CACNG4 MED13L DLG1 DLG4 MSN SREBF2 TEAD1 CACNA1D CACNA1C DCC PITPNA NTN1 AJUBA CLASP1 TGS1 PAXIP1 ACTB HIST1H2AE SPTAN1 HIST1H2AD HIST3H2BB HIST1H2AC HIST1H2AB DSP HIST1H2AJ DSG1 HIST2H3A PKP1 HIST1H2BF PRKCQ ROBO2 HIST1H2BE DSG2 NELL2 HIST1H2BH SLIT1 HIST1H2BG DSG3 HIST2H3D SLIT3 SLIT2 HIST1H2BB ROBO1 HIST1H2BA HIST2H3C HIST1H2BD HIST1H2BC L1CAM H2AFB1 ITGA5 ITGA9 HIST1H3J LEFTY1 LEFTY2 HIST1H3A DAND5 HIST1H3F HIST1H3G NODAL CER1 HIST1H3H CFC1 RPS4Y2 HIST1H3I RPS4Y1 HIST1H3B HIST1H3C HIST1H3D HIST1H3E H3F3B GFI1 CEBPA HIST1H4K CEBPE FLI1 HIST1H4L H3F3A HIF3A KLF5 H2BFS CUL2 HIST1H4A HIST1H4B HIST1H4H HIST1H4I HIST1H4J HIST1H4C HIST1H4D HIST1H4E EZH2 HIST1H4F HIST2H2AA3 YY1 NRTN GSK3B GFRA1 HIST2H2AA4 SPTB GFRA2 GFRA4 SPTBN4 HIST2H2AC SPTBN5 CACNA1H CACNA1G SPTA1 CACNA1I H2AFJ SPTBN1 SPTBN2 PRNP PSPN GDNF PTPRA EED ARTN H2AFZ CNTN2 NCOR2 H2AFX NCOR1 H2AFV HIST2H2BE PLIN1 ABL1 KAT2B ANGPTL4 KAT2A HIST4H4 RPS15A HIST1H2BN HIST1H2BM HDAC2 HIST1H2BO PRDM14 HIST1H2BJ TRPC5 LIN28A ZSCAN10 TRPC4 HIST1H2BI HIST1H2BL HIST1H2BK PLXNA4 HIST2H4A HIST2H4B RBBP4 RPL10L RPL10A POLR2E POLR2F POLR2H RBBP7 POLR2K POLR2L SUZ12 MAPK8 DEK RPL13A PLXND1 CNTN1 CYP51A1 ARHGAP39 RPS15 RPS14 RPS17 RPS16 RPS19 RPL18A SRGAP3 RPL36AL SRGAP1 RPS18 RPS11 RPS10 RPS13 PSMD8 PSMD9 RPS12 PSMD6 SH3KBP1 SRC PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 TRPC7 AKT1 PSMD1 ADAM10 TRPC6 TRPC3 PRKCA PTPN11 PSMA5 PSMA6 ARHGEF7 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 HELZ2 RHOC PSME4 PSME1 PSME2 RHOB PABPC1 SMAD2 UBA52 SMAD3 PSMD10 RPS26 PSMB11 TIAM1 PSMD12 RPS25 RPS28 GSPT2 PSMD11 GSPT1 PSMD14 RPS27 UPF3A PSMD13 RPS29 PSMA7 PSMB10 RPS20 PSMA8 RPS21 RPS24 UPF2 RPS23 PSMB6 ETF1 PSMB7 PSMB4 PSMB5 PSMB2 UBB PSMB3 GRB10 UBC PSMB1 GAB2 PSMF1 RPS27A HSPA8 SHFM1 SIAH2 SIAH1 PSMB8 PSMB9 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 ARHGAP35 EIF4G1 DOK1 EPAS1 VLDLR KIF4B KIF4A LPL IL6R RBX1 C6 DEAMINATION OF ADENOSINE%REACTOME%R-HSA-75102.2 C6 deamination of adenosine ADAR ADARB1 STEROLS ARE 12-HYDROXYLATED BY CYP8B1%REACTOME DATABASE ID RELEASE 72%211994 Sterols are 12-hydroxylated by CYP8B1 PTGIS CYP8B1 POSITIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%R-HSA-5250913.4 Positive epigenetic regulation of rRNA expression RBBP4 TAF1B TAF1C TAF1A TWISTNB POLR2E POLR2F POLR2H RBBP7 MTA2 SF3B1 MTA3 POLR2K POLR2L MBD3 DEK GATAD2B GATAD2A MYBBP1A ERCC6 EHMT2 TTF1 ACTB HIST1H2AE HIST1H2AD HIST3H2BB HIST1H2AC HIST1H2AB HIST1H2AJ CHD4 CD3EAP HIST2H3A HIST1H2BF HIST1H2BE HIST1H2BH EP300 HIST1H2BG HIST2H3D HIST1H2BB HIST1H2BA HIST2H3C HIST1H2BD HIST1H2BC H2AFB1 HIST1H3J HIST1H3A HIST1H3F HIST1H3G HIST1H3H HIST1H3I HIST1H3B HIST1H3C HIST1H3D HIST1H3E H3F3B HIST1H4K CBX3 HIST1H4L H3F3A SMARCA5 H2BFS HIST1H4A HIST1H4B HIST1H4H HIST1H4I HIST1H4J HIST1H4C HIST1H4D HIST1H4E HIST1H4F HIST2H2AA3 GSK3B HIST2H2AA4 CHD3 HIST2H2AC ZNRD1 H2AFJ TBP H2AFZ H2AFX H2AFV BAZ1B HIST2H2BE KAT2B KAT2A POLR1A HIST4H4 POLR1B POLR1C POLR1E HIST1H2BN HIST1H2BM HDAC2 HIST1H2BO HIST1H2BJ HDAC1 HIST1H2BI HIST1H2BL HIST1H2BK DDX21 HIST2H4A TAF1D HIST2H4B MTA1 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES%REACTOME%R-HSA-450282.1 MAPK targets Nuclear events mediated by MAP kinases PPP2CA PPP2CB MAPK14 MAPK11 MAPK9 MAPK8 PPP2R1B ATF1 PPP2R1A ATF2 MAPK10 JUN ELK1 RPS6KA3 RPS6KA5 RPS6KA2 RPS6KA1 DUSP4 PPP2R5D MEF2A MEF2C DUSP3 FOS VRK3 DUSP6 DUSP7 CREB1 MAPKAPK2 MAPK7 MAPK1 MAPK3 DISEASES ASSOCIATED WITH THE TLR SIGNALING CASCADE%REACTOME%R-HSA-5602358.1 Diseases associated with the TLR signaling cascade IKBKB CHUK IRAK4 TIRAP TLR1 UNC93B1 TLR6 TLR2 NFKB1 NFKB2 TLR10 TLR5 BTK CD36 LY96 TICAM1 NFKBIA TRAF3 IKBKG CD14 TLR3 TLR4 MYD88 RELA SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24-HYDROXYCHOLESTEROL%REACTOME%R-HSA-193775.1 Synthesis of bile acids and bile salts via 24-hydroxycholesterol PTGIS CYP46A1 AKR1D1 HSD3B7 AKR1C1 AMACR AKR1C3 AKR1C2 CYP39A1 AKR1C4 SLC27A2 SLC27A5 CYP8B1 CYP27A1 IMATINIB-RESISTANT PDGFR MUTANTS%REACTOME DATABASE ID RELEASE 72%9674396 Imatinib-resistant PDGFR mutants PDGFRA ORGANELLE BIOGENESIS AND MAINTENANCE%REACTOME%R-HSA-1852241.5 Organelle biogenesis and maintenance ATP5G2 ATP5G1 PRKAR2B KIF3A TTC21B YWHAG IFT122 ATP5F1 MKS1 IFT52 IFT57 OFD1 IFT140 GLUD1 WDR35 GLUD2 ARF4 PKD2 PKD1 BBS9 PRKAA2 CNGA2 BBS7 WDR19 CNGA4 BBS5 BBS4 MT-ATP6 MKKS CYS1 SSTR3 LZTFL1 BBS10 RP2 BBS12 UNC119B ARL6 ARL3 ASAP1 MCHR1 NPHP3 RAB11FIP3 BBS2 BBS1 RAB3IP BBIP1 DYNLL2 RAB11A TTC8 NPHP3-ACAD11 CARM1 MT-ATP8 GBF1 TRAF3IP1 CEP97 IFT80 IFT81 FBF1 TTBK2 DYNC2LI1 B9D2 WDR60 CEP83 CEP89 CEP57 C2CD3 CETN2 HSPB11 TCTN3 CEP164 CCP110 TCTN2 TCTN1 ACTR1A CC2D2A PCM1 KIF24 CNTRL WDR34 TMEM67 CEP250 ATAT1 NEK2 NINL TTC30B TTC30A CEP290 PPARGC1A RAB8A B9D1 CDK5RAP2 TCTEX1D1 PPARGC1B CEP135 NPHP1 TRIP11 TCTEX1D2 NPHP4 MARK4 TUBB IFT20 CEP131 AHI1 IFT22 HAUS4 IFT27 HAUS3 DYNLRB2 HAUS6 CSNK1D DYNLRB1 TTC26 HAUS5 CSNK1E IQCB1 TUBG1 TCTE3 DYNLL1 SEPT2 CKAP5 IFT43 HAUS2 TMEM216 HAUS1 IFT46 AKAP9 IFT74 CEP63 SCLT1 MAPRE1 CEP162 CLUAP1 SFI1 CRTC2 PAFAH1B1 CRTC3 SDCCAG8 CRTC1 ESRRA TFB1M DYNC1I2 CHCHD3 DCTN2 SSNA1 CHCHD6 MTERF1 DCTN3 GABPA C19orf70 HAUS8 SIRT4 HAUS7 CEP70 SIRT5 CEP72 TFB2M CEP192 PPRC1 PCNT POLRMT CEP76 SIRT3 POLG2 CLASP1 TFAM CEP78 PLK4 PERM1 APOO DYNC1H1 SAMM50 ODF2 MINOS1 CEP152 NDE1 HSPA9 APOOL NEDD1 MTX1 FGFR1OP TGS1 MTX2 CEP41 C10orf2 DNAJC11 IMMT SOD2 TMEM11 CAMK4 SSBP1 SMARCD3 ACSS2 PLK1 CDK1 TUBA4A NR1D1 INPP5E TUBA1A CCT3 CCT2 TCP1 NCOR1 HDAC3 CCT8 HCFC1 CCT5 CCT4 TUBB4B TUBB4A TBL1X ATP5C1 TBL1XR1 PPP2R1A PRKACA ATP5S ATP5J ATP5I ATP5H ATP5O ATP5L ATP5B ATP5E EXOC8 EXOC7 ATP5D EXOC4 KIF17 EXOC3 EXOC6 EXOC5 EXOC2 EXOC1 PRKAB2 PRKAB1 RHO CNGB1 NCOA1 NCOA2 CREBBP NCOA6 RXRA PPARA ATP5A1 PRKAG1 PRKAG2 PRKAG3 TNPO1 HELZ2 ATF2 NRF1 MEF2C CENPJ MAPK12 CHD9 CREB1 MEF2D ALAS1 MAPK14 MAPK11 KIFAP3 KIF3B KIF3C HSP90AA1 ATP5J2 HDAC6 IDH2 MED1 CYCS IFT172 YWHAE DYNC2H1 RPGRIP1L IFT88 SMO ATP5G3 ARL13B PDE6D CALMODULIN INDUCED EVENTS%REACTOME DATABASE ID RELEASE 72%111933 Calmodulin induced events CAMK2D CAMK2A PRKAR2B PRKAR2A PRKCD PRKCA CAMK2G PRKCG NBEA CAMK4 CAMKK1 ADCY4 CAMKK2 ADCY3 PRKACG ADCY2 ADCY1 PRKACA ADCY8 PRKACB ADCY7 ADCY6 PDE1B ADCY5 PDE1C PDE1A ADRBK1 PRKX KPNA2 CREB1 ADCY9 PRKAR1B PRKAR1A CAMK2B GLUTAMATE AND GLUTAMINE METABOLISM%REACTOME DATABASE ID RELEASE 72%8964539 Glutamate and glutamine metabolism CCBL1 PYCR1 OAT GOT2 PYCR2 GLUL GLUD1 GLS GLUD2 RIMKLA PYCRL RIMKLB GLS2 HS-GAG DEGRADATION%REACTOME DATABASE ID RELEASE 72%2024096 HS-GAG degradation SDC4 SDC2 SDC3 GPC1 HPSE2 GPC3 GPC2 GPC5 GPC4 IDUA GPC6 SGSH GLB1 HSPG2 NAGLU IDS SDC1 GUSB HPSE AGRN GLB1L UBIQUINOL BIOSYNTHESIS%REACTOME%R-HSA-2142789.1 Ubiquinol biosynthesis COQ3 COQ2 COQ9 PDSS2 COQ7 PDSS1 COQ6 COQ5 UPTAKE AND FUNCTION OF ANTHRAX TOXINS%REACTOME DATABASE ID RELEASE 72%5210891 Uptake and function of anthrax toxins MAP2K1 MAP2K2 MAP2K4 MAP2K7 FURIN PDCD6IP DEFECTIVE ABCB11 CAUSES PROGRESSIVE FAMILIAL INTRAHEPATIC CHOLESTASIS 2 AND BENIGN RECURRENT INTRAHEPATIC CHOLESTASIS 2%REACTOME DATABASE ID RELEASE 72%5678520 Defective ABCB11 causes progressive familial intrahepatic cholestasis 2 and benign recurrent intrahepatic cholestasis 2 ABCB11 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK%REACTOME%R-HSA-380972.1 Energy dependent regulation of mTOR by LKB1-AMPK TSC2 PRKAB1 TSC1 RRAGA RRAGC RRAGB RRAGD SLC38A9 CAB39 CAB39L PRKAA1 PRKAA2 STRADA STRADB PPM1A MTOR RHEB LAMTOR2 LAMTOR1 LAMTOR4 LAMTOR3 LAMTOR5 PRKAG1 STK11 MLST8 PRKAG2 PRKAG3 RPTOR PRKAB2 BIOSYNTHESIS OF DPAN-3 SPMS%REACTOME DATABASE ID RELEASE 72%9025094 Biosynthesis of DPAn-3 SPMs PTGS2 ALOX15 ALOX12 ALOX5 LIPID PARTICLE ORGANIZATION%REACTOME%R-HSA-8964572.1 Lipid particle organization FITM2 HILPDA CIDEA HSD17B13 FITM1 CIDEC TRANSMISSION ACROSS ELECTRICAL SYNAPSES%REACTOME%R-HSA-112307.1 Transmission across Electrical Synapses PANX2 GJC1 GJD2 PANX1 GJA10 CELL CYCLE%REACTOME DATABASE ID RELEASE 72%1640170 Cell Cycle EXO1 CUL1 RAB1B PRKAR2B TOPBP1 YWHAG ZNF385A YWHAH RFC5 RFC3 RFC4 RFC2 PPP2R5C ERCC6L OFD1 ZWILCH RBL2 BUB1B CCNA2 CASC5 CCNA1 SMC3 TFDP1 CDC20 RBL1 TFDP2 PTTG1 KNTC1 DYNC1LI1 BIRC5 DYNC1LI2 CLIP1 ZW10 MAD1L1 CDCA5 CSNK2A1 CDCA8 PDS5B PDS5A CSNK2A2 PMF1 SKA1 AURKB SKA2 AURKA DSN1 RAD21 E2F1 RBBP8 RCC2 NDC80 E2F4 ZWINT STAG1 KIF18A CSNK2B STAG2 SGOL2 SGOL1 NUF2 WAPAL SPDL1 NDEL1 NUDC SMC1A DYNLL2 ESPL1 RAD50 KIF2A INCENP KIF2C KIF2B ITGB3BP MIS12 CENPA NSL1 CENPC BUB3 BUB1 DYNC1I1 CLASP2 CENPT FZR1 CENPU E2F2 CENPE E2F3 CENPF GINS1 CENPH GINS2 CENPI GINS3 TAOK1 GINS4 CENPK CENPL CHMP2A CENPM CENPN B9D2 CENPO CENPP CENPQ SPC24 MAD2L1 SPC25 LPIN1 LPIN2 NEK9 LPIN3 NEK6 NEK7 MAU2 NIPBL TUBB6 ANAPC15 ANAPC16 TUBB3 ANAPC7 TUBB1 UBE2C PLK1 UBE2E1 UBE2D1 ANAPC10 ANAPC11 CCNB1 CDC23 CDC26 CDC27 CDC16 CDK1 ANAPC4 TUBA4B ANAPC5 ANAPC1 TUBA4A ANAPC2 KPNB1 RB1 GMNN MYC CDKN2D FBXO5 CDKN2B SKP2 CDKN2C CDC25A MAX ORC5 ORC4 ORC6 ORC1 ORC3 ORC2 CDT1 CDC7 CDC6 HSP90AB1 POLA1 POLA2 LIN54 MCM7 MCM8 MCM10 TUBA8 CKS1B LIN52 WRAP53 DBF4 TUBA1C MCM3 TUBA1B MCM4 MCM5 TUBA1A MCM6 MCM2 PRIM2 LIN37 PRIM1 TUBB2B LIN9 TUBB2A CDC45 E2F5 E2F6 CABLES1 PPP2R3B WEE1 RPA4 TUBAL3 TUBA3E TUBB4B TUBB4A FEN1 BLM PCNA LIG1 RPA1 RPA2 POLD3 HSPA2 POLD4 WRN RPA3 POLD1 POLD2 DNA2 NUP107 NUP188 JAK2 BANF1 PPP2R1B PPP2R1A NUP62 PRKACA NDC1 NUP214 SEC13 NUP133 NUP210 PPP2R5D PRDM9 NUP93 NUP50 NUP54 CCND1 RUVBL2 ANKLE2 DHFR EMD VRK1 LEMD3 SIRT2 POM121 NUP205 AAAS NUP160 PPP2CA PPP2CB NUP85 TPR NUP88 NUP43 RAE1 RANBP2 NUP155 NUP153 CDK4 NUP35 NUPL2 NUP37 AKT2 AKT3 SUMO1 PRKCB VPS4A PIAS4 CCND3 CCND2 CDK6 CHMP2B CHMP4C CHMP4B CHMP3 CHMP4A CHMP6 CHMP7 EP300 MAPK1 AHCTF1 RANGAP1 RCC1 PKMYT1 FOXM1 RAN MYBL2 TUBB8P12 TUBB8 HSP90AA1 SPAST LEMD2 CC2D1B LYN CDC25B LMNB1 GOLGA2 CEP57 CETN2 CEP164 CCP110 PPP1CB ACTR1A PCM1 CNTRL CEP250 NEK2 NINL MSH4 CEP290 MSH5 RAB8A CDK5RAP2 FKBP6 CEP135 SYCE3 BORA SYCE2 PPP1R12A SYCE1 STAG3 FBXW11 SYCP2 TUBB CEP131 SYCP1 HAUS4 SPO11 SYNE2 HAUS3 SYNE1 HAUS6 CSNK1D SUN2 HAUS5 UBE2I SUN1 TEX12 CSNK1E TEX15 TUBG1 DYNLL1 SMC1B DMC1 CKAP5 HAUS2 PSMC3IP HAUS1 MND1 REC8 AKAP9 CEP63 MLH3 SYCP3 MAPRE1 AJUBA SFI1 OPTN PAFAH1B1 SDCCAG8 DYNC1I2 DCTN2 SSNA1 DCTN3 CCNB2 HAUS8 HAUS7 CEP70 HERC2 CEP72 STRA13 CEP192 PCNT CEP76 CLASP1 CEP78 PLK4 TINF2 DYNC1H1 ODF2 CEP152 NDE1 NEDD1 FGFR1OP CEP41 CCNH RRM2 BRCC3 SMC4 SMC2 HIST1H2AE EML4 TP53BP1 HIST1H2AD HIST3H2BB NCAPG ARPP19 ACD HIST1H2AC NCAPH HIST1H2AB NCAPH2 NCAPG2 HIST1H2AJ ENSA NCAPD2 NCAPD3 HIST2H3A CTDNEP1 HIST1H2BF NUMA1 HIST1H2BE CNEP1R1 HIST1H2BH HIST1H2BG MASTL HIST2H3D MCPH1 HIST1H2BB PPP2R2D HIST1H2BA HIST2H3C HIST1H2BD HIST1H2BC BRCA2 H2AFB1 HIST1H3J BABAM1 UIMC1 HIST1H3A HIST1H3F HIST1H3G HIST1H3H HIST1H3I TERF1 HJURP TERF2 HIST1H3B RSF1 HIST1H3C MIS18BP1 RNF168 OIP5 HIST1H3D CENPW HIST1H3E H3F3B RAD51C MIS18A POT1 HIST1H4K HIST1H4L H3F3A SMARCA5 H2BFS HIST1H4A CDK7 HIST1H4B HIST1H4H HIST1H4I HIST1H4J APITD1 HIST1H4C MNAT1 HIST1H4D HIST1H4E HIST1H4F HIST2H2AA3 GSK3B HIST2H2AA4 RUVBL1 HIST2H2AC H2AFJ TK1 UBE2V2 H2AFZ H2AFX H2AFV HIST2H2BE ABL1 CLSPN USO1 HIST4H4 IST1 HIST1H2BN HIST1H2BM HIST1H2BO HIST1H2BJ HDAC1 FAM175A HIST1H2BI HIST1H2BL HIST1H2BK HIST2H4A HIST2H4B RBBP4 WHSC1 POLE GTSE1 FKBPL RFC1 PPP1CC GORASP1 RBBP7 TERF2IP RNF8 DSCC1 RAB2A CHTF18 OBFC1 GORASP2 BLZF1 DKC1 NHP2 PIF1 HMMR CHTF8 TERT GAR1 ESCO1 CTC1 ESCO2 TEN1 NOP10 POLE4 RAD51 BRE POLE2 LBR HIST3H3 POLE3 MDC1 KAT5 CHEK2 CHEK1 HUS1 TP53 RHNO1 BRIP1 PCBP4 SFN ATRIP BARD1 TPX2 PPME1 PHLDA1 TUBGCP2 TUBGCP5 RAD17 TUBGCP6 TUBGCP3 ATM TUBGCP4 FBXL7 TUBG2 MZT2B ATR CDKN1A MZT2A NME7 LCMT1 CDKN1B CDK11A FBXL18 SETD8 MZT1 YWHAB PHF20 PSMD8 PSMD9 PSMD6 BRCA1 XPO1 PSMD7 PSMD4 PSMD5 PSMD2 PPP2R5E PSMD3 AKT1 PSMD1 TNPO1 RTEL1 PPP2R5B PPP2R5A PRKCA YWHAZ RMI2 PSMA5 PSMA6 PSMA3 RMI1 PSMA4 PSMA1 TOP3A PSMA2 PSME3 PSME4 PSME1 PSME2 UBA52 PSMD10 PSMB11 PSMD12 SET PPP2R2A PSMD11 RPS27 PSMD14 DYRK1A TOP2A NPM1 PSMD13 CDKN1C CDKN2A PSMA7 MRE11A PSMB10 PSMA8 MLH1 PSMB6 PSMB7 PSMB4 CENPJ PSMB5 PSMB2 RAD1 UBB PSMB3 RFWD2 UBC PSMB1 PSMF1 RPS27A CDC14A SHFM1 TYMS PSMB8 NBN PSMB9 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 CDC25C CCNE2 CCNE1 UBE2N KIF20A PTK6 CDK2 MDM2 KIF23 MDM4 RAD9B RAD9A BTRC SKP1 YWHAE RBX1 YWHAQ RAB1A HDL CLEARANCE%REACTOME DATABASE ID RELEASE 72%8964011 HDL clearance HDLBP APOA1 AMN CUBN REPRODUCTION%REACTOME%R-HSA-1474165.3 Reproduction RPA1 RPA2 HSPA2 RPA3 TERF2IP SMC3 RAD21 RAD51 PRDM9 RBBP8 STAG1 B4GALT1 STAG2 HIST3H3 SMC1A RAD50 LMNB1 CDK4 MSH4 MSH5 FKBP6 SYCE3 SYCE2 SYCE1 STAG3 SYCP2 SYCP1 SPO11 SYNE2 SYNE1 ATM SUN2 UBE2I SUN1 TEX12 TEX15 ATR SMC1B DMC1 PSMC3IP MND1 REC8 MLH3 SYCP3 BRCA1 TINF2 TOP3A HIST1H2AE HIST1H2AD HIST3H2BB HIST1H2AC ACD HIST1H2AB HIST1H2AJ MRE11A HIST2H3A HIST1H2BF MLH1 HIST1H2BE HIST1H2BH HIST1H2BG HIST2H3D HIST1H2BB HIST1H2BA HIST2H3C HIST1H2BD HIST1H2BC H2AFB1 BRCA2 HIST1H3J HIST1H3A HIST1H3F HIST1H3G HIST1H3H HIST1H3I TERF1 HIST1H3B TERF2 HIST1H3C HIST1H3D HIST1H3E H3F3B RAD51C NBN HIST1H4K POT1 HIST1H4L H3F3A H2BFS HIST1H4A HIST1H4B HIST1H4H HIST1H4I HIST1H4J HIST1H4C HIST1H4D HIST1H4E HIST1H4F HIST2H2AA3 HIST2H2AA4 HIST2H2AC H2AFJ H2AFZ H2AFX H2AFV CATSPER1 HIST2H2BE CATSPER3 CATSPER2 CATSPER4 HVCN1 ADAM21 HIST4H4 ADAM20 CDK2 OVGP1 IZUMO3 IZUMO2 IZUMO4 IZUMO1 HIST1H2BN ADAM30 ADAM2 HIST1H2BM ACR KCNU1 HIST1H2BO CATSPERB HIST1H2BJ CATSPERD CATSPERG HIST1H2BI CD9 ZP1 HIST1H2BL ZP3 HIST1H2BK ZP2 SPAM1 HIST2H4A ZP4 BLM HIST2H4B LOSS OF FUNCTION OF MECP2 IN RETT SYNDROME%REACTOME%R-HSA-9005891.2 Loss of function of MECP2 in Rett syndrome HDAC3 NCOR1 TBL1X CAMK4 HDAC1 TBL1XR1 GPS2 SIN3A PRKACA NCOR2 DEFECTIVE SLC6A19 CAUSES HARTNUP DISORDER (HND)%REACTOME%R-HSA-5659735.1 Defective SLC6A19 causes Hartnup disorder (HND) SLC6A19 NTRK3 AS A DEPENDENCE RECEPTOR%REACTOME DATABASE ID RELEASE 72%9603505 NTRK3 as a dependence receptor NELFB BAX NTRK3 FLT3 SIGNALING%REACTOME%R-HSA-9607240.3 FLT3 Signaling CAMK2D CAMK2A RANBP9 CAMK2G RASGRF2 PPP2R5C DLG1 DLG4 RASGRP1 RASGRP3 ARRB1 IL2RG JAK3 DUSP5 DUSP2 DUSP1 DUSP8 DUSP9 DUSP16 DUSP10 PEA15 IQGAP1 SPRED3 PHB SPRED2 SPRED1 SYNGAP1 HCK HRAS RASA3 RASA4 RASA1 RASA2 CUL3 BTC RASAL1 EPGN RASAL2 TGFA RASAL3 AREG NRAS HBEGF DAB2IP EREG NF1 KBTBD7 PDGFRB KIT PDGFB SPTAN1 PPP5C FGB FGA VWF STAT5A STAT5B FGG IRS1 IRS2 THEM4 WDR83 PAQR3 BRAP RET GFRA3 IL17RD RAPGEF2 IL5RA SHC3 RASGRP4 IL5 MAP3K11 RASGEF1A IL3RA IL2RB NRTN GFRA1 SPTB EGF GFRA2 SHC1 GAB1 GFRA4 SPTBN4 PIK3R1 SPTBN5 EGFR PIK3CA SPTA1 SOS1 SPTBN1 SPTBN2 PSPN GDNF PTPRA PIK3C3 ARTN TLN1 MAP2K1 MAP2K2 BRAF RAF1 JAK2 ACTN2 FGF6 FGF9 PPP2R1B PPP2R1A FGF20 FGF1 FGF2 FGF23 FGF3 FGF22 FGF10 FGF4 PIK3R4 PPP2R5D GRIN2B GRIN2D CSF2RB CSF2RA PPP2CA PPP2CB NEFL TLR9 LRRC7 GRIN1 ITGB3 PIK3CB YWHAB AKT2 PSMD8 PSMD9 PSMD6 SRC PSMD7 PSMD4 PSMD5 IL3 CSK PSMD2 PPP2R5E PSMD3 PDPK1 NCAM1 PSMD1 PPP2R5B PPP2R5A PTPN11 PSMA5 TRIB3 PSMA6 PSMA3 PSMA4 PSMA1 ITGA2B SHC2 ARAF PSMA2 PEBP1 PSME3 ARRB2 PSME4 DLG2 PSME1 PSME2 DLG3 KSR1 UBA52 PIK3R2 RASGRF1 KSR2 PSMD10 APBB1IP PSMB11 CNKSR2 PSMD12 CNKSR1 PSMD11 PSMD14 VCL FYN PSMD13 PSMA7 PSMB10 PSMA8 RAP1B MARK3 FN1 PSMB6 DUSP4 PSMB7 PTK2 HGF PSMB4 MET RAP1A PSMB5 PSMB2 LAMTOR2 KLB CSF2 UBB FLT3 PSMB3 PDE3B DUSP6 LAMTOR3 FLT3LG DUSP7 UBC GAB2 PSMB1 PSMF1 IL2 FGF19 FGFR4 JAK1 RPS27A IL2RA SHFM1 PSMB8 PSMB9 PSMC5 MAPK1 PSMC6 PSMC3 MAPK3 PSMC4 PSMC1 PSMC2 NRG1 NRG2 FRS2 FRS3 FGF16 NRG3 FGF7 NRG4 FGF18 PDGFRA ERBB2 ANGPT1 RBX1 TEK CAMK2B INTERLEUKIN-27 SIGNALING%REACTOME%R-HSA-9020956.1 Interleukin-27 signaling JAK2 EBI3 IL6ST STAT1 CRLF1 JAK1 STAT3 IL27 IL27RA CANX TYK2 LEADING STRAND SYNTHESIS%REACTOME%R-HSA-69109.3 Leading Strand Synthesis POLD3 RFC1 POLD4 POLD1 POLA1 POLD2 RFC5 POLA2 RFC3 RFC4 RFC2 PRIM2 PRIM1 PCNA SYNTHESIS OF GDP-MANNOSE%REACTOME%R-HSA-446205.1 Synthesis of GDP-mannose PMM2 MPI GMPPB PMM1 GMPPA CGMP EFFECTS%REACTOME%R-HSA-418457.1 cGMP effects PDE1A PDE2A PDE11A PDE10A KCNMB1 KCNMA1 KCNMB2 KCNMB3 KCNMB4 MRVI1 PRKG2 PDE5A PDE9A ITPR1 PDE1B BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS%REACTOME%R-HSA-2173782.1 Binding and Uptake of Ligands by Scavenger Receptors ALB COLEC12 COLEC11 MSR1 SCARA5 APOE MARCO APOB SCGB3A2 MASP1 CALR COL1A1 COL3A1 COL1A2 COL4A2 SPARC COL4A1 FTH1 IGKV1-12 HSPH1 IGKV2D-28 FTL IGKV4-1 HBB IGHA1 IGKV2D-30 APOA1 JCHAIN HBA2 HBA1 IGKV3-11 CD163 IGKV2-28 CD36 HSP90AA1 SAA1 IGKV3D-20 STAB2 HP LRP1 HSP90B1 SCARF1 IGKV5-2 STAB1 HPR HYOU1 HPX AMBP APOL1 SSC5D COX REACTIONS%REACTOME%R-HSA-140180.1 COX reactions PTGS1 BETA OXIDATION OF BUTANOYL-COA TO ACETYL-COA%REACTOME DATABASE ID RELEASE 72%77352 Beta oxidation of butanoyl-CoA to acetyl-CoA HADH ACADS ECHS1 ACSM3 ACSM6 CILIUM ASSEMBLY%REACTOME DATABASE ID RELEASE 72%5617833 Cilium Assembly PRKAR2B KIF3A TTC21B YWHAG IFT122 MKS1 IFT52 IFT57 OFD1 IFT140 WDR35 PPP2R1A PRKACA ARF4 PKD2 PKD1 BBS9 CNGA2 BBS7 CNGA4 WDR19 BBS5 BBS4 MKKS CYS1 SSTR3 LZTFL1 BBS10 RP2 BBS12 UNC119B ARL6 ARL3 ASAP1 MCHR1 NPHP3 EXOC8 RAB11FIP3 EXOC7 BBS2 BBS1 RAB3IP BBIP1 DYNLL2 RAB11A TTC8 NPHP3-ACAD11 EXOC4 KIF17 EXOC3 EXOC6 EXOC5 EXOC2 EXOC1 GBF1 RHO CNGB1 TRAF3IP1 CEP97 IFT80 IFT81 FBF1 TTBK2 DYNC2LI1 B9D2 WDR60 CEP83 CEP89 CEP57 C2CD3 CETN2 HSPB11 CEP164 TCTN3 CCP110 TCTN2 TCTN1 ACTR1A CC2D2A PCM1 KIF24 CNTRL WDR34 CEP250 TMEM67 NEK2 ATAT1 NINL TTC30B CEP290 TTC30A RAB8A B9D1 CDK5RAP2 TCTEX1D1 CEP135 NPHP1 TCTEX1D2 TRIP11 NPHP4 MARK4 IFT20 TUBB CEP131 AHI1 IFT22 HAUS4 IFT27 HAUS3 DYNLRB2 HAUS6 CSNK1D DYNLRB1 TTC26 HAUS5 CSNK1E IQCB1 TCTE3 TUBG1 DYNLL1 SEPT2 CKAP5 IFT43 HAUS2 TMEM216 HAUS1 IFT46 AKAP9 IFT74 CEP63 SCLT1 MAPRE1 CEP162 CLUAP1 SFI1 PAFAH1B1 SDCCAG8 DYNC1I2 DCTN2 SSNA1 DCTN3 HAUS8 HAUS7 CEP70 CEP72 CEP192 TNPO1 PCNT CEP76 CLASP1 CEP78 PLK4 DYNC1H1 ODF2 CEP152 NDE1 NEDD1 FGFR1OP CEP41 PLK1 CENPJ CDK1 TUBA4A KIFAP3 INPP5E TUBA1A CCT3 KIF3B CCT2 KIF3C HSP90AA1 TCP1 HDAC6 CCT8 CCT5 CCT4 IFT172 YWHAE DYNC2H1 TUBB4B RPGRIP1L TUBB4A IFT88 SMO ARL13B PDE6D HCMV EARLY EVENTS%REACTOME DATABASE ID RELEASE 72%9609690 HCMV Early Events RBBP4 TBL1X HIST2H2AB RBBP7 NUP107 NUP188 SUZ12 TBL1XR1 DYNC1LI1 HIST2H2BF DYNC1LI2 NUP62 NDC1 NUP214 SEC13 NUP133 NUP210 HIST3H2A NUP93 TRIM28 NUP50 NUP54 HIST1H2AG HIST1H2AA HIST1H2AM DYNLL2 PML HIST1H2AL GPS2 HIST1H2AI HIST1H2AH POM121 HIST1H2AK NUP205 DAXX AAAS NUP160 NUP85 DYNC1I1 TPR NUP88 NUP43 RAE1 RANBP2 NUP155 NFKB1 NUP153 NUP35 NUPL2 NUP37 DYNLL1 DYNC1I2 DYNC1H1 HIST1H2AE HIST1H2AD HIST3H2BB HIST1H2AC HIST1H2AB HIST1H2AJ ELK1 HIST2H3A HIST1H2BF HIST1H2BE HIST1H2BH HIST1H2BG HIST2H3D HIST1H2BB CBX1 HIST1H2BA HIST2H3C HIST1H2BD HIST1H2BC HIST1H3J HIST1H3A HIST1H3F HIST1H3G HIST1H3H CREB1 HIST1H3I HIST1H3B HIST1H3C HIST1H3D HIST1H3E HIST1H4K HIST1H4L HIST1H4A HIST1H4B HIST1H4H HIST1H4I HIST1H4J HIST1H4C HIST1H4D HIST1H4E EZH2 HIST1H4F HIST2H2AA3 HIST2H2AA4 HIST2H2AC EGFR EED NCOR2 NCOR1 HDAC3 HIST2H2BE HIST4H4 HIST1H2BN ITGB1 HIST1H2BM HIST1H2BO HIST1H2BJ HIST1H2BI HIST1H2BL HIST1H2BK HIST2H4A HIST2H4B HISTIDINE CATABOLISM%REACTOME%R-HSA-70921.3 Histidine catabolism HDC CARNS1 FTCD UROC1 HAL AMDHD1 C9orf41 HNMT L1CAM INTERACTIONS%REACTOME DATABASE ID RELEASE 72%373760 L1CAM interactions RPS6KA4 LAMA1 MAP2K1 MAP2K2 DNM1 ANK2 DNM3 ANK3 RANBP9 SHTN1 LAMB1 EZR RPS6KA6 NRP2 DLG1 DLG4 KCNQ2 NFASC KCNQ3 NUMB CSNK2A1 CSNK2A2 SH3GL2 GAP43 EPHB2 MSN CNTNAP1 CSNK2B DCX NRCAM SCN11A SCN9A SCN1B SCN1A SCN10A SCN8A CNTN1 ITGA1 SCN3B SCN3A SCN2A SCN2B SDCBP ITGB3 CLTC CLTA AP2A1 SCN5A AP2B1 AP2A2 AP2S1 AP2M1 ITGAV RAC1 SCN4A SCN4B NCAM1 VAV2 SCN7A ITGA2B DLG3 PAK1 SPTAN1 RPS6KA3 RPS6KA5 RPS6KA2 RPS6KA1 L1CAM ITGA5 ITGA9 DNM2 HSPA8 MAPK1 MAPK3 NRP1 CNTN6 CHL1 ITGA10 ANK1 SPTB SPTBN4 SPTBN5 EGFR SPTA1 SPTBN1 SPTBN2 KIF4B ALCAM KIF4A CNTN2 DPYSL2 RDX LYPLA2 NCAN ITGB1 LAMC1 ITGA2 DEFECTIVE SLC7A7 CAUSES LYSINURIC PROTEIN INTOLERANCE (LPI)%REACTOME%R-HSA-5660862.1 Defective SLC7A7 causes lysinuric protein intolerance (LPI) SLC7A7 SLC3A2 DEFECTIVE SLC12A3 CAUSES GITELMAN SYNDROME (GS)%REACTOME%R-HSA-5619087.1 Defective SLC12A3 causes Gitelman syndrome (GS) SLC12A3 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP)%REACTOME%R-HSA-2559582.2 Senescence-Associated Secretory Phenotype (SASP) CXCL8 CCNA2 CCNA1 RELA EHMT1 FZR1 IL6 NFKB1 CDK4 JUN CDKN1A CDKN1B IL1A EHMT2 CDK6 UBA52 HIST1H2AE HIST1H2AD HIST3H2BB HIST1H2AC HIST1H2AB HIST1H2AJ CDKN2A RPS6KA3 HIST2H3A HIST1H2BF RPS6KA2 HIST1H2BE RPS6KA1 HIST1H2BH ANAPC15 HIST1H2BG ANAPC16 ANAPC7 HIST2H3D HIST1H2BB UBE2C HIST1H2BA UBE2E1 HIST2H3C UBE2D1 HIST1H2BD HIST1H2BC ANAPC10 H2AFB1 ANAPC11 FOS UBB CDC23 HIST1H3J CDC26 CDC27 HIST1H3A UBC HIST1H3F CDC16 HIST1H3G ANAPC4 HIST1H3H ANAPC5 HIST1H3I ANAPC1 RPS27A ANAPC2 HIST1H3B HIST1H3C HIST1H3D HIST1H3E H3F3B HIST1H4K MAPK7 CDKN2D HIST1H4L MAPK1 CDKN2B H3F3A CDKN2C MAPK3 H2BFS HIST1H4A HIST1H4B HIST1H4H HIST1H4I HIST1H4J HIST1H4C HIST1H4D HIST1H4E IGFBP7 HIST1H4F HIST2H2AA3 HIST2H2AA4 HIST2H2AC H2AFJ CEBPB H2AFZ H2AFX H2AFV HIST2H2BE HIST4H4 CDK2 VENTX HIST1H2BN HIST1H2BM HIST1H2BO HIST1H2BJ STAT3 HIST1H2BI HIST1H2BL HIST1H2BK HIST2H4A HIST2H4B SOS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 72%112412 SOS-mediated signalling HRAS SOS1 NRAS IRS1 IRS2 ABC TRANSPORTERS IN LIPID HOMEOSTASIS%REACTOME%R-HSA-1369062.2 ABC transporters in lipid homeostasis ABCA2 ABCA5 ABCG1 ABCA9 ABCA7 ABCD2 ABCD3 PEX3 PEX19 ABCA3 APOA1 ABCG8 ABCA12 ABCG5 ABCA10 ABCG4 ABCD1 ABCA6 INTERLEUKIN-33 SIGNALING%REACTOME DATABASE ID RELEASE 72%9014843 Interleukin-33 signaling IL1RL1 IL33 SHC-MEDIATED CASCADE:FGFR4%REACTOME DATABASE ID RELEASE 72%5654719 SHC-mediated cascade:FGFR4 HRAS FGF16 KLB FGF18 NRAS FGF19 FGFR4 FGF6 FGF9 SOS1 FGF20 FGF1 FGF2 FGF23 FGF4 ACTIVATION, TRANSLOCATION AND OLIGOMERIZATION OF BAX%REACTOME%R-HSA-114294.2 Activation, translocation and oligomerization of BAX BAX BID SUMOYLATION OF RNA BINDING PROTEINS%REACTOME DATABASE ID RELEASE 72%4570464 SUMOylation of RNA binding proteins SUMO2 NUP85 TPR NUP88 NUP43 HNRNPK RAE1 HNRNPC RANBP2 NUP107 NUP155 NUP188 NUP153 NUP62 NUP35 NUPL2 NDC1 NUP214 SEC13 NUP37 NUP133 NUP210 BMI1 RNF2 NUP93 NUP50 UBE2I CBX8 NOP58 NUP54 PHC2 PHC1 RING1 CBX4 CBX2 PCGF2 PHC3 POM121 NUP205 AAAS SUMO1 NUP160 ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS%REACTOME DATABASE ID RELEASE 72%181431 Acetylcholine binding and downstream events CHRNA1 CHRNB2 CHRND CHRNB4 CHRNA3 CHRNB3 CHRNA2 CHRNA5 CHRNG CHRNA4 CHRNA7 CHRNE CHRNA6 CHRNA9 INTRACELLULAR SIGNALING BY SECOND MESSENGERS%REACTOME DATABASE ID RELEASE 72%9006925 Intracellular signaling by second messengers CAMK2D PRKAR2B CAMK2A PRKAR2A CAMK2G PRKCG PPP2R5C ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 FOXO6 CSNK2A1 ADCY5 FOXO4 NR4A1 RPS6KB2 CSNK2A2 BMI1 RNF2 CSNK2B CBX8 XIAP PHC2 PHC1 RING1 CBX4 CBX2 PML TNRC6C PHC3 FOXO1 CD86 LCK CD80 CD28 TNRC6A TNRC6B FOXO3 BTC EPGN TGFA AREG HBEGF EREG PRKX IER3 PDGFRB KIT PHLPP2 PHLPP1 PDGFB ESR2 STRN PIK3AP1 CAMK4 TRIM27 IRS1 IRS2 THEM4 TRAT1 EZH2 PIK3CD GSK3B EGF GAB1 PIK3R1 CHD3 EGFR PIK3CA PLCG1 EED HDAC3 HDAC2 HDAC1 MTA1 CBX6 RBBP4 RBBP7 MTA2 MTA3 MECOM MBD3 SUZ12 FGF6 FGF9 PPP2R1B PPP2R1A FGF20 PRKACG GATAD2B FGF1 FGF2 PRKACA GATAD2A FGF23 PRKACB FGF3 FGF22 FGF10 FGF4 PPP2R5D IL1RL1 PIK3R3 PIP5K1A PIP5K1B KDM1A IL33 PIP5K1C PREX2 USP13 TNKS TNKS2 WWP2 RNF146 STUB1 FRK OTUD3 PIP4K2A PIP4K2B PIP4K2C PPP2CA PPP2CB RRAGA RRAGC GSK3A CHUK RRAGB BAD CASP9 RRAGD MKRN1 IRAK4 TP53 ESR1 IRAK1 CAMKK1 CAMKK2 JUN MYD88 PDE1B PDE1A MOV10 AGO3 AGO4 AGO1 AGO2 PPARG PRR5 AHCYL1 CDKN1A CD19 CDKN1B PIK3CB AKT2 PRKCE PSMD8 AKT3 PSMD9 MLST8 PSMD6 SRC PSMD7 PSMD4 RAC1 PSMD5 PSMD2 RPTOR PPP2R5E PSMD3 PDPK1 AKT1 PSMD1 VAV1 PPP2R5B PRKCD PPP2R5A PRKCA PTPN11 RAC2 PSMA5 TRIB3 PSMA6 RHOG PSMA3 PSMA4 SALL4 PSMA1 PSMA2 PSME3 MAPKAP1 PSME4 PSME1 PSME2 ITPR1 NBEA ITPR2 UBA52 ATN1 ITPR3 PIK3R2 NR2E1 MAF1 PSMD10 SNAI1 PSMB11 SNAI2 PSMD12 ATF2 RICTOR PSMD11 PSMD14 FYN PSMD13 CHD4 PSMA7 PDE1C PSMB10 PSMA8 ADRBK1 PSMB6 PSMB7 MTOR HGF PSMB4 MET PSMB5 PSMB2 LAMTOR2 KLB UBB PSMB3 LAMTOR1 LAMTOR4 INSR LAMTOR3 LAMTOR5 UBC PSMB1 PSMF1 KPNA2 FGF19 CREB1 FGFR4 RPS27A SHFM1 PSMB8 PSMB9 PSMC5 MAPK1 PSMC6 PSMC3 USP7 MAPK3 EGR1 PSMC4 PSMC1 PSMC2 TSC2 NRG1 NRG2 FRS2 REST NEDD4 FGF16 NRG3 FGF7 NRG4 FGF18 INS PDGFRA SLC38A9 ERBB2 AKT1S1 HDAC5 RHEB HDAC7 MDM2 TRAF6 PTEN ADCY9 PRKAR1B PRKAR1A CAMK2B SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL%REACTOME DATABASE ID RELEASE 72%1855183 Synthesis of IP2, IP, and Ins in the cytosol ISYNA1 IMPA1 SYNJ1 IMPA2 INPP1 MIOX INPP5B INPP5A MTMR9 INPP5J OCRL MTMR7 INPP4A INPP4B ACTIVATION OF RAC1%REACTOME DATABASE ID RELEASE 72%428540 Activation of RAC1 PAK2 SLIT2 ROBO1 SOS2 PAK7 PAK6 PAK4 PAK1 SOS1 NCK2 RAC1 NCK1 PAK3 ASSEMBLY OF ACTIVE LPL AND LIPC LIPASE COMPLEXES%REACTOME%R-HSA-8963889.2 Assembly of active LPL and LIPC lipase complexes ANGPTL3 GPIHBP1 C19orf80 LPL ANGPTL4 LMF2 LMF1 FGF21 MBTPS1 MBTPS2 APOA4 LIPC APOA5 CREB3L3 APOC2 FURIN PCSK6 PCSK5 AROMATIC AMINES CAN BE N-HYDROXYLATED OR N-DEALKYLATED BY CYP1A2%REACTOME%R-HSA-211957.1 Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 CYP1A2 TRANSPORT OF GLYCEROL FROM ADIPOCYTES TO THE LIVER BY AQUAPORINS%REACTOME DATABASE ID RELEASE 72%432030 Transport of glycerol from adipocytes to the liver by Aquaporins AQP9 AQP7 SIGNALING BY NOTCH4%REACTOME DATABASE ID RELEASE 72%9013694 Signaling by NOTCH4 PSMD3 AKT1 CUL1 NCSTN PSMD1 ADAM10 APH1B YWHAZ PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME1 PSME2 UBA52 SMAD3 PSENEN PSMD10 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 EP300 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 UBB PSMB3 UBC PSMB1 PSMF1 RPS27A SHFM1 PSMB8 PSMB9 PSMC5 PSMC6 PSMC3 NOTCH1 PSMC4 MAML2 PSMC1 PSMC2 MAML1 TACC3 RBPJ HES1 FLT4 SNW1 MAML3 MAMLD1 ACTA2 NOTCH2 NOTCH4 CREBBP HEY1 HEY2 KAT2B KAT2A DLL4 HES5 JAG1 SKP1 PSMD8 PSMD9 PSMD6 RBX1 PSEN2 PSMD7 PSEN1 PSMD4 PSMD5 PSMD2 APH1A AMPK INHIBITS CHREBP TRANSCRIPTIONAL ACTIVATION ACTIVITY%REACTOME DATABASE ID RELEASE 72%163680 AMPK inhibits chREBP transcriptional activation activity ADIPOQ MLXIPL STK11 PRKAG2 ADIPOR1 ADIPOR2 PRKAA2 PRKAB2 SUPPRESSION OF AUTOPHAGY%REACTOME%R-HSA-9636569.1 Suppression of autophagy DUSP16 RAB7A NONHOMOLOGOUS END-JOINING (NHEJ)%REACTOME%R-HSA-5693571.1 Nonhomologous End-Joining (NHEJ) WHSC1 HERC2 PIAS4 PAXIP1 PRKDC RNF8 BRCC3 TP53BP1 HIST3H2BB NHEJ1 XRCC6 XRCC4 XRCC5 POLM MRE11A HIST1H2BF HIST1H2BE HIST1H2BH HIST1H2BG TDP2 TDP1 HIST1H2BB HIST1H2BA BRE HIST1H2BD HIST1H2BC HIST3H3 BABAM1 UIMC1 MDC1 KAT5 RNF168 RAD50 NBN HIST1H4K HIST1H4L H2BFS HIST1H4A HIST1H4B HIST1H4H HIST1H4I HIST1H4J HIST1H4C HIST1H4D HIST1H4E DCLRE1C UBE2N RIF1 HIST1H4F LIG4 BARD1 UBE2V2 H2AFX HIST2H2BE ATM HIST4H4 HIST1H2BN HIST1H2BM HIST1H2BO HIST1H2BJ HIST1H2BI FAM175A HIST1H2BL BRCA1 HIST1H2BK HIST2H4A SUMO1 HIST2H4B POLL NUCLEOSOME ASSEMBLY%REACTOME%R-HSA-774815.1 Nucleosome assembly RBBP4 STRA13 RBBP7 CASC5 HIST1H2AE HIST1H2AD HIST3H2BB HIST1H2AC HIST1H2AB HIST1H2AJ NPM1 HIST1H2BF HIST1H2BE HIST1H2BH HIST1H2BG HIST1H2BB HIST1H2BA HIST1H2BD HIST1H2BC H2AFB1 HJURP RSF1 MIS18BP1 OIP5 CENPW MIS18A HIST1H4K ITGB3BP HIST1H4L CENPA SMARCA5 CENPC H2BFS HIST1H4A HIST1H4B HIST1H4H CENPT HIST1H4I CENPU HIST1H4J APITD1 HIST1H4C CENPH HIST1H4D CENPI HIST1H4E CENPK CENPL HIST1H4F HIST2H2AA3 CENPM CENPN HIST2H2AA4 RUVBL1 CENPO CENPP CENPQ HIST2H2AC H2AFJ H2AFZ H2AFX H2AFV HIST2H2BE HIST4H4 HIST1H2BN HIST1H2BM HIST1H2BO HIST1H2BJ HIST1H2BI HIST1H2BL HIST1H2BK HIST2H4A HIST2H4B INSULIN RECEPTOR RECYCLING%REACTOME DATABASE ID RELEASE 72%77387 Insulin receptor recycling ATP6V1B2 ATP6V0C ATP6V0D2 ATP6V1B1 ATP6V1A ATP6V0A2 ATP6V1H ATP6V0A4 INS ATP6V0E2 ATP6V1G3 ATP6V1D ATP6V1C1 ATP6V1F ATP6V0A1 ATP6V1C2 INSR TCIRG1 ATP6V1E1 ATP6V1E2 ATP6V1G1 ATP6V0B ATP6V0E1 ATP6V1G2 ATP6AP1 ATP6V0D1 ACTIVATION OF RAS IN B CELLS%REACTOME%R-HSA-1169092.1 Activation of RAS in B cells HRAS RASGRP1 RASGRP3 NRAS KANDUTSCH-RUSSELL PATHWAY%REACTOME DATABASE ID RELEASE 72%6807062 Kandutsch-Russell pathway DHCR7 EBP DHCR24 SC5D DEFENSINS%REACTOME%R-HSA-1461973.1 Defensins DEFB107B DEFB104B DEFB106B DEFA1B DEFB104A DEFB119 DEFB118 DEFB116 DEFB115 DEFB136 DEFB114 DEFB135 DEFB113 CCR6 DEFB134 DEFB112 DEFB133 CCR2 DEFB132 DEFB108B DEFB110 DEFB131 DEFB106A DEFB4A DEFB4B CD4 PRSS3 TLR1 TLR2 PRSS2 ART1 DEFA6 DEFA5 DEFA3 DEFB103A DEFB103B DEFB105A DEFB105B DEFB129 DEFB128 DEFB127 DEFB126 DEFB125 DEFB124 DEFB1 DEFB123 DEFA4 DEFB107A DEFA1 DEFB121 GLUTATHIONE CONJUGATION%REACTOME DATABASE ID RELEASE 72%156590 Glutathione conjugation MGST3 GGT1 GGCT MGST1 MGST2 GSTK1 GSTA5 GSTA4 GSTA3 GSTA2 GSTO2 GSTA1 GSTT2B GSTO1 CNDP2 GGT5 GSTT2 GGT7 GSTT1 GGT6 AKR1A1 GSTZ1 GCLC GCLM GSTM4 HPGDS GSTM3 CHAC2 GSTM2 CHAC1 GSTM1 GSTP1 ESD GSS GSTM5 OPLAH INFECTIOUS DISEASE%REACTOME%R-HSA-5663205.10 Infectious disease CASP1 PRKAR2B CDH1 TCEB3C RPS4X PRKAR2A TCEB3B RPS3A HTR6 HTR7 GNAS CPSF4 HTR4 ADCY4 ADCY3 DYNC1LI1 DYNC1LI2 ADCY2 ADCY1 ADCY8 PABPN1 ADCY7 ADCY6 ADCY5 TAF9 TAF1L SH3GL2 TRIM28 TAF15 TLR2 TAF12 TAF13 TAF10 TXNRD1 TAF11 RNF213 SSRP1 DYNLL2 PML CTDP1 TAF7 NCBP1 TAF6 NCBP2 TAF5 SUPT4H1 TAF4 LCK SUPT5H TAF3 GTF2F1 TAF2 GTF2F2 CD28 POLR2A DYNC1I1 POLR2B TAF1 NMT1 POLR2C POLR2D AVP POLR2G NELFB NELFA NELFCD POLR2I POLR2J NELFE PPIA CHMP2A NMT2 PDCD6IP RANBP1 HBEGF ARF1 RPLP1 C3 RPLP0 RPLP2 FURIN RPS27L TRIM27 GNAT3 RPL22L1 KPNB1 GNAZ GNG10 GNG12 GNG11 GNG13 GNB2 GNB1 GNB4 HSP90AB1 GNB3 GNB5 GNGT1 GNGT2 CBL EGFR PLCG1 CBLL1 HDAC3 TGFB1 GNAI3 GNAI1 GNAI2 GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 FEN1 LIG1 GTF2B GTF2A1 GTF2A2 RNMT GTF2E1 GTF2E2 RNGTT RPL23A HIST2H2AB NUP107 NUP188 PSIP1 ENO1 BANF1 KPNA1 HMGA1 ENTPD1 PRKACG HIST2H2BF NUP62 PRKACA PRKACB ENTPD5 NDC1 NUP214 RELA SEC13 NUP133 NUP210 HIST3H2A NUP93 NUP50 CTSG NUP54 HIST1H2AG HIST1H2AA HIST1H2AM HIST1H2AL HIST1H2AI POM121 HIST1H2AH NUP205 HIST1H2AK AAAS NUP160 NUP85 TPR PGK1 RPL27A NUP88 NUP43 RAE1 RANBP2 MYO5A WASL NUP155 NFKB1 NFKB2 NUP153 NUP35 NUPL2 NUP37 CYFIP2 CYFIP1 NCKAP1 AHCYL1 STX1B WNT5A CLTC CLTA CTNND1 BRK1 AP2A1 AP2B1 AP2A2 AP2S1 AP2M1 RAC1 NCK1 VAV3 CYBA VAV1 TSG101 VPS4B VAV2 GGT1 VPS4A ELMO1 MVB12B ELMO2 MVB12A VPS36 SYT2 CRK DPEP2 VTA1 VPS37C DPEP1 DOCK1 VPS37D DPEP3 VPS37A STAM SNF8 VPS37B CHMP2B ITPR1 CCR5 CHMP4C UBAP1 ITPR2 CXCR4 ITPR3 CHMP4B CHMP3 CDC42 CHMP4A CHMP6 VPS25 MRC1 SH3GL3 STAM2 CHMP7 VPS28 NCKAP1L FYN CHMP5 WASF1 ELK1 GGT5 WASF2 PAK2 WASF3 BAIAP2 PTK2 MET ABI2 ABI1 CTNNB1 CREB1 MAPK1 MAPK3 VAMP1 MAPK14 RANGAP1 RCC1 RAN RPL26L1 RPL4 RPL5 HSP90AA1 RPL30 RPL3 RPL32 RPL31 RPL34 SLC25A5 RPL8 SLC25A4 RPL9 SLC25A6 RPL6 RPL7 RPL36 RPL35 RPL38 RPL37 RPL39 RPL21 RPL23 ITGB1 RPL22 RPL24 IPO5 RPL27 RPL26 GRSF1 RPL29 RPL28 PLCG2 CANX RPL41 CALR RPL3L VIPR1 VIPR2 SCT RXFP1 RXFP2 IGHG4 CYSLTR1 GPR176 IGHG1 IGHG2 IGKV1-12 PTGDR LHCGR TAAR8 TAAR9 TAAR6 TAAR5 TAAR2 TAAR1 ADCYAP1 ADAM17 IGKV2D-28 IGKV4-1 IAPP ADCYAP1R1 CALCA CALCRL CALCB RPL10 IGKV2D-30 RPL12 GIPR RPL11 GPR83 GPS2 ADRB1 GPR84 RPS3 ADRB2 RPL14 CRHR1 RPL13 CRHR2 GHRHR GCG RPS2 MC2R RPL15 CALCR RPL18 HRH2 RPL17 DRD1 RPL19 IGKV3-11 DRD5 LYN CD163 GPR15 YES1 HNRNPK DUSP16 IL6 MC1R RLN2 RLN3 GPR27 GPR25 GPR20 ADM CD3G PTH1R MC4R FCGR3A IGKV2-28 INSL3 IL10 GPR39 SYK FSHB GPR32 AVPR2 GLP2R RHBDF2 RPS9 IGKV3D-20 RPS7 GPBAR1 PTH2R RPS8 RPS5 GIP RPS6 MC3R HCK RPSA ADORA2A ADRB3 ADORA2B FSHR CRH MYH9 NPSR1 PTGER4 RAMP2 RAMP3 GPR45 DYNLL1 PTH PTGER2 PRKX PTH2 PTHLH NPS GPR150 FCGR1A GPHA2 P2RY11 IGKV5-2 SCTR DYNC1I2 TSHR FCGR2A GHRH ADM2 MC5R VIP RAMP1 GPHB5 WIPF1 WIPF2 WIPF3 C3AR1 RPL7A TXNIP DYNC1H1 MEFV NOX1 ARPC1B ARPC1A IL18 IL1A CCNH IL1B WAS NOXO1 MYO9B ACTG1 PYCARD RPL37A ACTB HGS VPS33B NCKIPSD DVL1 RAB5A HIST1H2AE CORO1A HIST1H2AD NLRP3 HIST3H2BB DVL3 RAB7A ARPC4 HIST1H2AC ARPC5 XRCC6 HIST1H2AB ARPC2 RPL36A XRCC4 ARPC3 XRCC5 HIST1H2AJ NOXA1 PSTPIP1 ACTR3 RPL35A HIST2H3A ACTR2 HIST1H2BF HIST1H2BE MYH2 MYO10 HIST1H2BH MYO1C HIST1H2BG HIST2H3D SUGT1 HIST1H2BB CBX1 CHMP1A HIST1H2BA HIST2H3C HIST1H2BD HIST1H2BC HIST1H3J HIST1H3A HIST1H3F HIST1H3G HIST1H3H RPS4Y2 HIST1H3I RPS4Y1 HIST1H3B HIST1H3C HIST1H3D HIST1H3E HIST1H4K HIST1H4L HIST1H4A CDK7 HIST1H4B CGA HIST1H4H HIST1H4I HIST1H4J HIST1H4C MNAT1 HIST1H4D HIST1H4E EZH2 HIST1H4F HIST2H2AA3 HIST2H2AA4 NEDD4L HIST2H2AC LIG4 RPL39L TBP EED NCOR2 NCOR1 HIST2H2BE ABL1 GUCY2C PDZD3 HIST4H4 RPS15A HIST1H2BN HIST1H2BM HIST1H2BO DNAJC3 HIST1H2BJ HIST1H2BI HIST1H2BL HIST1H2BK HIST2H4A HIST2H4B RBBP4 RPL10L RPL10A MAP2K1 TBL1X MAP2K2 CYSLTR2 POLR2E POLR2F POLR2H RBBP7 FAU POLR2K POLR2L SUZ12 GTF2H1 MAPK8 GTF2H2 GTF2H3 TBL1XR1 GTF2H4 GTF2H5 ERCC3 ERCC2 CEBPD CD4 CD8B DOCK2 CCNK RPL13A TSHB DAXX EEF2 GSK3A MAP2K4 ATP6V1H TXN MAP2K7 POMC JUN NOS2 PLK2 RPS15 RPS14 AP1G1 RPS17 RPS16 PACS1 AP1S2 RPS19 AP1B1 AP1S1 RPL18A AP1S3 RPL36AL RPS18 HLA-A B2M AP1M2 ELL AP1M1 RPS11 RPS10 RPS13 PSMD8 PSMD9 RPS12 PSMD6 SH3KBP1 SRC XPO1 PSMD7 PSMD4 PSMD5 SNAP25 PSMD2 TAF7L EPS15 LTF SYT1 PSMD3 SH3GL1 PTGIR PSMD1 FGR PSMA5 PSMA6 P2RX7 PSMA3 PSMA4 LHB PSMA1 P2RX4 STX1A PSMA2 VAMP2 PSME3 TCEB3CL2 PSME4 PSME1 PSME2 UBA52 TCEB3 RPS26 TCEB2 PSMD10 TCEB1 PSMB11 TCEB3CL RPS25 PSMD12 TAF9B RPS28 PSMD11 RPS27 PSMD14 NPM1 PSMD13 RPS29 PSMA7 RPS20 PSMB10 PSMA8 RPS21 RPS24 DVL2 RPS23 PSMB6 PSMB7 FZD7 PSMB4 PSMB5 TCEA1 PSMB2 SV2B UBB SV2A PSMB3 KPNA7 KPNA4 UBC PSMB1 KPNA5 PSMF1 CCNT2 KPNA2 CCNT1 KPNA3 RPS27A SHFM1 PSMB8 PSMB9 PSMC5 PSMC6 SUPT16H PSMC3 PSMC4 NT5E PSMC1 PSMC2 EIF2AK2 ISG15 SFPQ AK6 SV2C CDK9 TAF4B BTRC CUL5 SKP1 BTK CD9 RBX1 ADCY9 GLP1R PRKAR1B PRKAR1A VESICLE-MEDIATED TRANSPORT%REACTOME%R-HSA-5653656.2 Vesicle-mediated transport NBAS RAB1B DCTN4 STX18 KIF3A BNIP1 GALNT2 YWHAG GALNT1 ARCN1 CAPZA3 YWHAH KIF26A KIF26B CAPZA1 CAPZA2 RAB18 RAB3GAP2 COPG2 COPG1 ACTR10 RAB3GAP1 DYNC1LI1 APP TFRC DYNC1LI2 ARF4 SNAP23 ZW10 CTSZ AP4E1 ARRB1 PRKAA2 SPARC CLINT1 AP4M1 AP1G2 FTH1 AP3S1 SH3GL2 SH3D19 TPD52 AP3B1 GAK VAMP8 VAMP7 DNAJC6 KIF18A DNASE2 FTL NAPA RAB5C TGOLN2 BLOC1S4 BLOC1S6 SNX2 BLOC1S1 RAB3IP BLOC1S3 DYNLL2 RAB11A CLVS2 STX4 KIF2A SNX9 AP4S1 KIF2C PLA2G6 SNX5 KIF2B TXNDC5 CLVS1 TBC1D8B SNAPIN SORT1 GBF1 DTNBP1 HIP1R DYNC1I1 LNPEP M6PR PUM1 TPD52L1 AVP CENPE AP4B1 IGF2R VAMP3 NECAP1 GOLGB1 CPD YIPF6 CHMP2A ACBD3 PICALM FZD4 PLA2G4A BTC EPGN TGFA AREG HBEGF EREG ARF3 ARF1 AGPAT3 STAB1 HPR HPX AMBP SSC5D USP6NL SCOC GJA3 GJA5 GJA4 GJA9 HSPH1 GJA8 GJC2 GJB4 F5 GJB3 GJB6 GJB5 GJB7 F8 GJD4 GJD3 TMF1 ARFRP1 RALGAPA2 CD3D RALGAPB RHOBTB3 ARL1 VPS51 VPS53 VPS52 VPS54 GCC2 GCC1 GOLGA1 ARFIP2 C2CD5 STX10 SYS1 ASPSCR1 RABEPK NAA30 TBC1D1 TRAPPC4 TBC1D4 NAA35 NAA38 EGF CBL EGFR SEC23A LRP1 ITSN2 SCARB2 CHRM2 FNBP1L AGFG1 FNBP1 LRP2 GAPVD1 BIN1 AGTR1 AMPH CFTR CLTCL1 PACSIN2 PACSIN3 KIAA0319 PACSIN1 TOR1A TOR1B SYT8 SNAP91 DAB2 AAK1 IL7R HIP1 STON1 SEC24B STON2 SEC24A SLC2A8 SGIP1 DNM1 EPN2 COLEC12 ANK2 DNM3 COLEC11 MSR1 CTTN VAMP4 ANK3 SCARA5 FCHO1 MARCO SCGB3A2 FCHO2 MASP1 REPS2 UBQLN1 REPS1 UBQLN2 SNX18 NECAP2 SEC24D SYT11 SEC24C GJC1 GJA10 SAR1B SEC13 KIF5B PIP5K1C KIF5A EXOC8 EXOC7 SLC2A4 EXOC4 EXOC3 EXOC6 EXOC5 EXOC2 EXOC1 RAB27B SLC18A3 GJD2 MYO5A RAB27A WASL CD36 TMED2 RAB6A WNT5A CLTC CLTB CLTA AP2A1 AP2B1 AP2A2 AP2S1 AKT2 AKT3 AP2M1 RAC1 CHML APOL1 TSG101 VPS4B VPS4A SBF1 MVB12B SBF2 MVB12A VPS36 SYT2 VTA1 SYT9 VPS37C RAB43 VPS37D VPS37A STAM SNF8 VPS37B ADRBK2 CHMP2B CHMP4C UBAP1 RAB32 CHMP4B CHMP3 RAB35 CHMP4A CHMP6 VPS25 RAB38 SH3GL3 STAM2 CHMP7 VPS28 CHMP5 GGA3 RAB21 STXBP3 ARF6 DNM2 RAB12 RAB13 SEC31A RAB39B RAB8B RAB33A INS RAB7B HSP90AA1 RAB11B RAB9A ITSN1 GRIA1 MYO6 APOE APOB NSF GJA1 CALR GJB2 GJB1 RALA IGKV1-12 IGKV2D-28 IGKV4-1 IGKV2D-30 ADRB2 NAPB STX16 GOSR1 GOLIM4 NAPG IGKV3-11 CYTH3 CYTH2 RAB41 CD163 GOLGA4 GOLGA5 GOLGA2 CYTH4 MAN2A2 CUX1 MAN1A2 MAN2A1 MAN1C1 STX6 VTI1A GGA2 GGA1 STX5 MAN1A1 SNAP29 CD3G YKT6 CYTH1 COG8 RIC1 IGKV2-28 COG7 COG6 COG5 COG4 COG3 ACTR1A COG2 AVPR2 RAB39A COG1 BET1L IGKV3D-20 RAB33B RGP1 GABARAPL2 RAB30 RAB8A RAB36 ALPP TRIP11 VPS45 ULK1 GABARAP MYH9 CSNK1D DYNLL1 HSP90B1 MAP1LC3B SCARF1 OPTN PAFAH1B1 IGKV5-2 DYNC1I2 DCTN2 DCTN3 ALB DYNC1H1 ARPC1A COPS7B COPS7A HGS RAB5A SPTAN1 RAB7A ARPC4 ARPC5 ARPC2 ARPC3 ACTR3 ACTR2 MYO1C TJP1 GNS GPS1 SERPINA1 SPTB SPTBN4 SPTBN5 SPTA1 SPTBN1 SPTBN2 DCTN1 TFG LMAN1L GOSR2 LMAN2L SCFD1 MIA2 PLIN3 MIA3 HP STAB2 STX17 USO1 LMAN1 LMAN2 TRAPPC10 SEC23IP LDLR RAB31 COPS4 COPS3 TRAPPC2L COPS6 ARFGAP1 TBC1D20 COPS5 TRAPPC2 ANKRD28 COPS2 TRAPPC3 SEC16B RAB5B SEC16A COPS8 TRAPPC5 PREB TRAPPC9 HYOU1 TRAPPC1 CNIH1 KDELR3 TMEM115 CNIH2 CNIH3 MCFD2 PPP6C PPP6R1 PPP6R3 TRAPPC6A TACR1 TRAPPC6B GORASP1 SEC22A SEC22C FOLR1 BET1 OCRL RAB10 TBC1D10C RAB4A CD4 SYNJ2 SYNJ1 PIK3C2A HBB IGHA1 APOA1 JCHAIN CTSC PRKAB2 PRKAB1 NEDD8 RAB14 SFN TF RAB9B SAA1 AP1G1 AP1S2 AP1B1 AP1S1 RACGAP1 AP1S3 AP1M2 AP1M1 CD59 DENND5B RABGEF1 YWHAB RINL CD55 TRAPPC12 PRKAG1 TRAPPC11 CHM DENND5A PRKAG2 SH3KBP1 TRAPPC13 TBC1D10A TBC1D10B SYTL1 PRKAG3 TBC1D24 RAB3A EPS15 TBC1D25 DENND6B SYT1 RIN3 AKT1 GDI1 SH3GL1 DENND6A RIN1 GDI2 EPS15L1 RIN2 TBC1D13 TBC1D14 EPN1 TBC1D17 TBC1D15 YWHAZ TBC1D16 ANKRD27 CCZ1B DENND4B DENND4A HPS1 VAMP2 CCZ1 HPS4 ARRB2 TRAPPC8 MON1A MON1B DENND1C UBA52 DENND1B DENND1A DENND2D DENND2C COL1A1 DENND2A RHOQ RAB3IL1 COL3A1 TBC1D2 COL1A2 TBC1D3 COL4A2 RABEP1 TRIP10 ALS2 COL4A1 TBC1D7 RABGAP1 DENND3 COL7A1 ADRBK1 ALS2CL ST5 DVL2 UBB UBC RPS27A HSPA8 HBA2 HBA1 TSC2 TSC1 KDELR1 KIF21A KIF21B KIFAP3 RINT1 KIF16B ANK1 KDELR2 KIF20A KIF20B COPB2 COPA TMED10 COPB1 KLC1 KLC4 KLC3 KLC2 KIF3B KIF3C RAB6B LDLRAP1 SURF4 KIF18B KIF4B KIF4A COPE KIF11 USE1 BICD1 BICD2 KIF15 KIF19 CAPZB KIF13B TMED3 KIF1C KIF1B KIF1A TMED7 TMED9 KIF25 COPZ2 KIF23 KIF22 ARFGAP3 KIF6 KIF27 COPZ1 ARFGAP2 KIF9 YWHAE KIFC2 KIFC1 SEC22B PAFAH1B3 ARF5 PAFAH1B2 YWHAQ DCTN6 RAB1A DCTN5 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER%REACTOME%R-HSA-76071.2 RNA Polymerase III Transcription Initiation From Type 3 Promoter POLR2E POLR2F POLR2H POLR2K POLR2L SNAPC5 SNAPC1 SNAPC2 SNAPC3 SNAPC4 ZNF143 BRF2 BDP1 TBP CRCP POLR1C POLR3GL POLR3A POLR3B POLR3C POLR3D POU2F1 POLR3E POLR3F POLR3G POLR3H POLR3K COMPLEMENT CASCADE%REACTOME%R-HSA-166658.2 Complement cascade COLEC11 C3AR1 FCN2 FCN3 MASP1 COLEC10 MBL2 PROS1 IGHG4 IGHG1 IGHG2 IGKV1-12 F2 IGKV2D-28 IGKV4-1 IGKV2D-30 SERPING1 CPB2 IGKV3-11 IGKV2-28 CD81 C4BPA C4BPB C8B FCN1 C8A CLU C4B C4A C8G IGKV3D-20 CR2 CR1 CD46 C1QB C1QA C1S CFH C1R C5AR2 C5AR1 CFI C4B_2 CRP CPN2 CPN1 C2 VTN C5 C6 C7 C9 CD19 CD59 CFD ELANE C3 CD55 GZMM CFHR2 CFB CFHR1 IGKV5-2 CFHR4 CFHR3 CFHR5 C1QC MUCOPOLYSACCHARIDOSES%REACTOME%R-HSA-2206281.1 Mucopolysaccharidoses SGSH GLB1 HYAL1 GALNS GNS HGSNAT NAGLU IDS GUSB ARSB IDUA RHO GTPASES ACTIVATE PKNS%REACTOME DATABASE ID RELEASE 72%5625740 RHO GTPases activate PKNs PDPK1 PKN3 PKN2 PKN1 YWHAG YWHAZ YWHAH PPP1R12B PPP1R14A RHOC RHOB HIST1H2AE PAK1 HIST1H2AD HIST3H2BB HIST1H2AC HIST1H2AB HIST1H2AJ HIST2H3A HIST1H2BF HIST1H2BE AR HIST1H2BH HIST1H2BG HIST2H3D HIST1H2BB HIST1H2BA KDM1A HIST2H3C HIST1H2BD HIST1H2BC H2AFB1 HIST1H3J HIST1H3A HIST1H3F HIST1H3G HIST1H3H MYH14 HIST1H3I MYH10 HIST1H3B HIST1H3C HIST1H3D HIST1H3E H3F3B HIST1H4K HIST1H4L H3F3A H2BFS HIST1H4A HIST1H4B CDC25C HIST1H4H HIST1H4I HIST1H4J MYL12B HIST1H4C HIST1H4D HIST1H4E MYH11 HIST1H4F HIST2H2AA3 HIST2H2AA4 HIST2H2AC PPP1CB H2AFJ SFN MYL6 MYL9 NCOA2 H2AFZ H2AFX PPP1R12A H2AFV HIST2H2BE MYH9 RHOA HIST4H4 HIST1H2BN HIST1H2BM YWHAB HIST1H2BO KDM4C HIST1H2BJ YWHAE HIST1H2BI HIST1H2BL HIST1H2BK KLK3 KLK2 RAC1 HIST2H4A YWHAQ HIST2H4B PHOSPHOLIPASE C-MEDIATED CASCADE: FGFR1%REACTOME DATABASE ID RELEASE 72%5654219 Phospholipase C-mediated cascade: FGFR1 FGF6 FGF9 PLCG1 FGF20 FGF1 FGF2 FGF23 FGF3 FGF22 FGF10 FGF4 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE%REACTOME DATABASE ID RELEASE 72%3371453 Regulation of HSF1-mediated heat shock response BAG4 HSPA4 RPA1 HSPA6 RPA2 HSPA2 RPA3 HSPA9 NUP107 NUP188 NUP62 NDC1 NUP214 SEC13 NUP133 NUP210 NUP93 HSPA4L NUP50 HSPH1 NUP54 ST13 MAPKAPK2 HSPA14 HSPA13 HSPA8 HSPA5 C11orf73 POM121 NUP205 MAPK1 AAAS DNAJB1 MAPK3 NUP160 HSPA1L NUP85 TPR NUP88 NUP43 BAG5 BAG2 BAG3 RAE1 BAG1 RANBP2 GSK3B NUP155 HSF1 DNAJC2 NUP153 DNAJC7 DNAJB6 NUP35 NUPL2 NUP37 CCAR2 SIRT1 ATM HSPA12A ATR HSPA12B YWHAE RPS19BP1 O-LINKED GLYCOSYLATION OF MUCINS%REACTOME%R-HSA-913709.3 O-linked glycosylation of mucins GALNT2 GALNT1 MUC20 GALNT12 ST3GAL4 ST3GAL1 C1GALT1C1 ST3GAL2 ST3GAL3 B4GALT6 GALNT11 MUC12 GALNT14 B4GALT5 GALNT13 MUC13 GALNT16 MUC15 GALNT15 GALNT18 GALNT10 WBSCR17 MUCL1 MUC3A GALNTL5 GALNTL6 B3GNTL1 MUC5AC GALNT9 GALNT8 ST6GALNAC2 B3GNT9 B3GNT8 B3GNT6 B3GNT5 CHST4 GCNT1 GCNT3 GCNT4 GCNT7 MUC1 GALNT7 ST6GAL1 GALNT6 GALNT5 GALNT4 A4GNT ST6GALNAC3 MUC7 ST6GALNAC4 MUC4 MUC6 GALNT3 MUC17 C1GALT1 MUC5B MUC21 B3GNT7 B3GNT4 B3GNT3 B3GNT2 AMINO ACID CONJUGATION%REACTOME DATABASE ID RELEASE 72%156587 Amino Acid conjugation GLYAT ACSM1 ACSM2B GLYATL3 GLYATL2 GLYATL1 ACSM2A ACSM5 ACSM4 DEFECTIVE SLC36A2 CAUSES IMINOGLYCINURIA (IG) AND HYPERGLYCINURIA (HG)%REACTOME DATABASE ID RELEASE 72%5619041 Defective SLC36A2 causes iminoglycinuria (IG) and hyperglycinuria (HG) SLC36A2 SUMOYLATION OF DNA DAMAGE RESPONSE AND REPAIR PROTEINS%REACTOME DATABASE ID RELEASE 72%3108214 SUMOylation of DNA damage response and repair proteins SUMO2 HERC2 RPA1 TDG WRN NUP107 NUP188 PIAS4 XPC SMC3 EID3 NUP62 XRCC4 NDC1 NUP214 CDKN2A SEC13 NUP133 NUP210 RAD52 RAD21 BMI1 NUP93 RNF2 NUP50 STAG1 CBX8 STAG2 NUP54 PHC2 MDC1 PHC1 RING1 PARP1 CBX4 CBX2 NSMCE4A PCGF2 SMC1A PML RNF168 PHC3 POM121 NSMCE2 NUP205 NSMCE1 AAAS NUP160 NUP85 TPR NUP88 NUP43 RAE1 RANBP2 NUP155 NUP153 CETN2 PIAS1 NUP35 NUPL2 NUP37 SMC5 HDAC7 SMC6 UBE2I BRCA1 SP100 NDNL2 SUMO1 BLM SUMO3 CHYLOMICRON CLEARANCE%REACTOME DATABASE ID RELEASE 72%8964026 Chylomicron clearance LDLR LIPC APOE LDLRAP1 APOB DEFECTIVE GGT1 CAUSES GLUTATHIONURIA (GLUTH)%REACTOME DATABASE ID RELEASE 72%5579022 Defective GGT1 causes Glutathionuria (GLUTH) GGT1 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING%REACTOME%R-HSA-163210.2 Formation of ATP by chemiosmotic coupling ATP5G2 ATP5J2 ATP5G1 ATP5S MT-ATP6 ATP5F1 ATP5J ATP5C1 ATP5I ATP5H ATP5O ATP5L ATP5B ATP5E ATP5D ATP5A1 ATP5G3 MT-ATP8 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS%REACTOME%R-HSA-174417.2 Telomere C-strand (Lagging Strand) Synthesis LIG1 RPA1 RPA2 POLD3 POLD4 RFC1 WRN RPA3 POLD1 POLD2 POLA1 RFC5 POLA2 DNA2 RFC3 RFC4 RFC2 DSCC1 CHTF18 OBFC1 PRIM2 PRIM1 CHTF8 CTC1 TEN1 FEN1 BLM PCNA SODIUM CALCIUM EXCHANGERS%REACTOME%R-HSA-425561.1 Sodium Calcium exchangers SRI SLC24A2 SLC24A4 SLC8B1 SLC8A3 SLC24A3 SLC24A5 SLC24A1 SLC8A1 SLC8A2 REGULATION OF IGF ACTIVITY BY IGFBP%REACTOME%R-HSA-381426.2 Regulation of IGF Activity by IGFBP SDC2 MEN1 LAMB2 APOE LAMB1 APOB MGAT4A TIMP1 CSF1 SPARCL1 APP HRC FGF23 DMP1 FSTL1 MSLN SPP2 GOLM1 CTSG TGOLN2 BMP15 APOA2 APOA1 ITIH2 QSOX1 APOA5 LGALS1 MATN3 MXRA8 SPP1 MMP1 MMP2 CALU MFI2 IL6 CHRDL1 CST3 CDH2 IGF1 ENAM MFGE8 GZMH CP TF C4A RCN1 LTBP1 GPC3 BMP4 HSP90B1 EVA1A CHGB FBN1 C3 SERPINA10 PRSS23 KLK3 KLK2 AFP CKAP4 APOL1 ALB KTN1 ADAM10 PLG IGF2 NUCB1 IGFBP5 PNPLA2 GAS6 IGFBP4 SERPINC1 KNG1 AMBN TMEM132A FSTL3 CYR61 MEPE FGA FN1 SERPIND1 NOTUM KLK13 FGG F2 F5 VGF PROC IGFBP3 STC2 FUCA2 TNC IGFBP7 SERPINA1 FAM20C VWA1 FAM20A PAPPA2 MBTPS1 IGFALS PCSK9 AHSG BPIFB2 IGFBP2 PENK IGFBP6 PAPPA KLK1 MIA3 APLP2 SHISA5 SCG3 SCG2 AMELX WFS1 VCAN P4HB PDIA6 IGFBP1 AMTN DNAJC3 LAMC1 PRKCSH ANO8 NOSTRIN MEDIATED ENOS TRAFFICKING%REACTOME DATABASE ID RELEASE 72%203641 NOSTRIN mediated eNOS trafficking NOS3 CAV1 WASL NOSTRIN DNM2 SYNDECAN INTERACTIONS%REACTOME%R-HSA-3000170.2 Syndecan interactions ITGB5 CASK THBS1 SDC4 SDC2 SDC3 TGFB1 ITGB4 PRKCA TNC TRAPPC4 ACTN1 VTN ITGA6 ITGB3 ITGB1 FGF2 SDC1 ITGAV ITGA2 TRANSCRIPTION OF E2F TARGETS UNDER NEGATIVE CONTROL BY DREAM COMPLEX%REACTOME%R-HSA-1362277.2 Transcription of E2F targets under negative control by DREAM complex RBBP4 E2F1 CDC6 E2F4 LIN54 LIN52 RBL2 TFDP1 HDAC1 RBL1 LIN37 TFDP2 LIN9 MYC E2F5 TOP2A CDC25A MAX PCNA DNA DOUBLE STRAND BREAK RESPONSE%REACTOME DATABASE ID RELEASE 72%5693606 DNA Double Strand Break Response WHSC1 HERC2 PIAS4 RNF8 UBA52 BRCC3 MAPK8 TP53BP1 HIST3H2BB KDM4A KDM4B EYA1 EYA2 MRE11A EYA3 HIST1H2BF EYA4 HIST1H2BE PPP5C HIST1H2BH HIST1H2BG HIST1H2BB HIST1H2BA BAP1 BRE HIST1H2BD HIST1H2BC UBB HIST3H3 BABAM1 UIMC1 MDC1 UBC KPNA2 RPS27A KAT5 RNF168 RAD50 CHEK2 NBN HIST1H4K HIST1H4L SMARCA5 H2BFS APBB1 HIST1H4A HIST1H4B HIST1H4H HIST1H4I HIST1H4J HIST1H4C HIST1H4D HIST1H4E UBE2N TP53 HIST1H4F BARD1 UBE2V2 H2AFX BAZ1B HIST2H2BE ABL1 ATM HIST4H4 UBE2I HIST1H2BN HIST1H2BM HIST1H2BO HIST1H2BJ HIST1H2BI FAM175A HIST1H2BL BRCA1 HIST1H2BK HIST2H4A SUMO1 HIST2H4B SIGNALING BY VEGF%REACTOME%R-HSA-194138.2 Signaling by VEGF NRP2 PRKACG PRKACA PRKACB FLT4 HRAS RASA1 PRR5 CYFIP2 CYFIP1 NCKAP1 AHCYL1 NRAS NCF1 NCF2 ITGB3 NCF4 CTNND1 BRK1 PIK3CB SHB FIGF CDH5 FLT1 HSPB1 AKT2 VEGFB AKT3 VEGFC PGF MLST8 KDR NCK2 ITGAV RAC1 NCK1 VAV3 PRKCB AAMP PDPK1 AKT1 SPHK1 CYBB CYBA VAV1 PRKCD VAV2 PRKCA MAPKAPK3 ELMO1 ELMO2 TRIB3 CRK DOCK1 SHC2 ROCK1 ROCK2 MAPKAP1 SH2D2A PXN ITPR1 ITPR2 ITPR3 PIK3R2 CDC42 PAK1 CTNNA1 PTK2B RICTOR NCKAP1L FYN WASF1 PAK3 WASF2 PAK2 WASF3 JUP NOS3 CAV1 BAIAP2 MTOR PTK2 MAPK12 MAPK13 ABI2 AXL ABI1 CTNNB1 THEM4 BCAR1 MAPKAPK2 MAPK14 MAPK11 NRP1 PIK3R1 PIK3CA PLCG1 HSP90AA1 PRKCZ RHOA VEGFA RETINOID CYCLE DISEASE EVENTS%REACTOME DATABASE ID RELEASE 72%2453864 Retinoid cycle disease events OPN1LW ABCA4 OPN1MW OPN1MW2 TTR RDH12 NAPEPLD LRAT OPN1SW RDH5 RBP4 RBP1 STRA6 RLBP1 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS%REACTOME%R-HSA-176187.2 Activation of ATR in response to replication stress ORC4 HUS1 ORC6 RPA1 ORC1 RPA2 ORC3 CDC25C ORC2 CDC7 RPA3 CDC6 RFC5 MCM7 RFC3 MCM8 RFC4 MCM10 RFC2 DBF4 MCM3 MCM4 MCM5 MCM6 MCM2 ATRIP CDC45 CLSPN RAD17 CDK2 RAD1 ATR RAD9B RAD9A CHEK1 CDC25A ORC5 NFG AND PRONGF BINDS TO P75NTR%REACTOME DATABASE ID RELEASE 72%205017 NFG and proNGF binds to p75NTR NGFR NGF PHASE 2 - PLATEAU PHASE%REACTOME DATABASE ID RELEASE 72%5576893 Phase 2 - plateau phase CACNA2D4 CACNG6 CACNG7 CACNG8 CACNB1 CACNB4 CACNG2 KCNQ1 CACNG3 KCNE1 CACNG4 KCNE2 KCNE3 KCNE4 KCNE5 CACNA2D2 CACNA1F CACNA1S CACNA1D CACNA1C CACNB2 CACNB3 AKAP9 CACNA2D1 CACNA2D3 INITIATION OF NUCLEAR ENVELOPE (NE) REFORMATION%REACTOME DATABASE ID RELEASE 72%2995383 Initiation of Nuclear Envelope (NE) Reformation PPP2CA LMNB1 CCNB1 LBR CDK1 BANF1 ANKLE2 EMD VRK1 KPNB1 LEMD3 SIRT2 PPP2R1A PPP2R2A LEMD2 CCNB2 TOXICITY OF BOTULINUM TOXIN TYPE B (BONT B)%REACTOME DATABASE ID RELEASE 72%5250958 Toxicity of botulinum toxin type B (BoNT B) SYT2 VAMP2 SYT1 TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS%REACTOME DATABASE ID RELEASE 72%168271 Transport of Ribonucleoproteins into the Host Nucleus NUP85 TPR NUP88 NUP43 RAE1 RANBP2 NUP107 NUP155 NUP188 KPNA1 NUP153 NUP62 NUP35 NUPL2 NDC1 NUP214 SEC13 NUP37 NUP133 NUP210 NUP93 NUP50 NUP54 KPNB1 POM121 NUP205 AAAS NUP160 TP53 REGULATES TRANSCRIPTION OF CASPASE ACTIVATORS AND CASPASES%REACTOME%R-HSA-6803207.1 TP53 Regulates Transcription of Caspase Activators and Caspases CRADD CASP1 CASP2 NLRC4 CASP10 ATM PIDD1 TP53 APAF1 TP63 TP73 CASP6 PHOSPHOLIPASE C-MEDIATED CASCADE; FGFR2%REACTOME DATABASE ID RELEASE 72%5654221 Phospholipase C-mediated cascade; FGFR2 FGF16 FGF7 FGF18 FGF6 FGF9 PLCG1 FGF20 FGF1 FGF2 FGF23 FGF3 FGF22 FGF10 FGF4 FGFR2 ALTERNATIVE SPLICING%REACTOME%R-HSA-6803529.2 FGFR2 alternative splicing GTF2F1 GTF2F2 POLR2A POLR2B POLR2C HNRNPM POLR2D POLR2G POLR2E POLR2F POLR2H POLR2I POLR2J POLR2K POLR2L PTBP1 TIAL1 TIA1 RBFOX2 ESRP2 ESRP1 HNRNPH1 HNRNPF HNRNPA1 NCBP1 NCBP2 DEFECTIVE UGT1A1 CAUSES HYPERBILIRUBINEMIA%REACTOME DATABASE ID RELEASE 72%5579002 Defective UGT1A1 causes hyperbilirubinemia UGT1A1 ASTROCYTIC GLUTAMATE-GLUTAMINE UPTAKE AND METABOLISM%REACTOME DATABASE ID RELEASE 72%210455 Astrocytic Glutamate-Glutamine Uptake And Metabolism SLC1A2 SLC1A3 GLUL SLC38A1 RESOLUTION OF ABASIC SITES (AP SITES)%REACTOME DATABASE ID RELEASE 72%73933 Resolution of Abasic Sites (AP sites) LIG1 MBD4 RPA1 POLE RPA2 POLD3 TDG POLD4 RFC1 RPA3 POLD1 APEX1 POLD2 RFC5 RFC3 MPG RFC4 NEIL2 NEIL1 PARG RFC2 PNKP ADPRHL2 NTHL1 LIG3 XRCC1 SMUG1 POLE4 OGG1 POLE2 POLE3 PARP1 PARP2 FEN1 POLB PCNA DEFECTIVE B3GALT6 CAUSES EDSP2 AND SEMDJL1%REACTOME DATABASE ID RELEASE 72%4420332 Defective B3GALT6 causes EDSP2 and SEMDJL1 SDC4 SDC2 SDC3 B3GALT6 GPC1 GPC3 GPC2 BCAN GPC5 VCAN GPC4 GPC6 NCAN BGN HSPG2 CSPG5 CSPG4 DCN SDC1 AGRN TWIK RELATED POTASSIUM CHANNEL (TREK)%REACTOME DATABASE ID RELEASE 72%1299503 TWIK related potassium channel (TREK) KCNK10 KCNK2 KCNK4 PEPTIDE HORMONE BIOSYNTHESIS%REACTOME%R-HSA-209952.1 Peptide hormone biosynthesis PCSK1 CGA INHBC INHBE FSHB POMC LHB INHA TSHB INHBB INHBA JOSEPHIN DOMAIN DUBS%REACTOME DATABASE ID RELEASE 72%5689877 Josephin domain DUBs UBC RPS27A UBA52 PARK2 VCP RAD23A ATXN3 UBB JOSD2 ATXN3L JOSD1 RAD23B CYCLIN A B1 B2 ASSOCIATED EVENTS DURING G2 M TRANSITION%REACTOME%R-HSA-69273.6 Cyclin A B1 B2 associated events during G2 M transition PPP2CA PPP2CB CDK7 CDC25C CDC25B MNAT1 CCNH PKMYT1 CCNA2 FOXM1 CCNA1 PPP2R1B PPP2R1A PPP2R2A PPP2R3B WEE1 PPME1 PLK1 CCNB1 CDK2 LCMT1 CDK1 XPO1 CDC25A CCNB2 FATTY ACYL-COA BIOSYNTHESIS%REACTOME%R-HSA-75105.6 Fatty acyl-CoA biosynthesis ELOVL5 ELOVL2 ELOVL3 ELOVL6 HACD1 CBR4 ELOVL7 OLAH SCD5 TECR SLC25A1 HACD3 PPT1 HACD2 ACACA PPT2 HACD4 ACLY SLC27A3 SCD ACSF3 MORC2 ACSBG1 ACSBG2 HSD17B3 HSD17B12 HSD17B8 ACSL1 ACSL6 FASN ACSL5 ACSL4 ACSL3 ELOVL1 TECRL ELOVL4 INTRAFLAGELLAR TRANSPORT%REACTOME%R-HSA-5620924.3 Intraflagellar transport KIF3A TNPO1 TTC21B IFT122 TRAF3IP1 KIFAP3 IFT80 IFT81 DYNC2LI1 IFT52 WDR60 IFT57 IFT140 HSPB11 WDR35 KIF3B KIF3C WDR34 TTC30B TTC30A TCTEX1D1 WDR19 TCTEX1D2 TRIP11 IFT20 IFT22 IFT27 DYNLRB2 DYNLRB1 TTC26 TCTE3 DYNLL1 IFT43 IFT46 IFT74 IFT172 DYNLL2 CLUAP1 DYNC2H1 KIF17 IFT88 PHENYLKETONURIA%REACTOME DATABASE ID RELEASE 72%2160456 Phenylketonuria PAH BASIGIN INTERACTIONS%REACTOME DATABASE ID RELEASE 72%210991 Basigin interactions ATP1B2 SLC7A7 SLC7A8 ATP1B1 SLC7A9 SLC3A2 PPIA ITGA6 SLC16A1 SLC7A5 CAV1 L1CAM SLC16A8 ITGB1 SLC16A3 MAG BSG SPN SLC7A11 SLC7A10 PPIL2 ITGA3 MMP1 ATP1B3 SLC7A6 PTK6 PROMOTES HIF1A STABILIZATION%REACTOME DATABASE ID RELEASE 72%8857538 PTK6 promotes HIF1A stabilization GPNMB LRRK2 PTK6 EGFR HBEGF HIF1A METABOLISM OF POLYAMINES%REACTOME%R-HSA-351202.3 Metabolism of polyamines PSMD3 PSMD1 NQO1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 PSMD10 PSMB11 PSMD12 SMS PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 AZIN2 AMD1 PSMB6 AZIN1 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 SAT1 PSMB1 PSMF1 SHFM1 PSMB8 PSMB9 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 PAOX OAZ1 OAZ2 OAZ3 SRM ODC1 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 AGMAT MITOCHONDRIAL TRANSLATION INITIATION%REACTOME%R-HSA-5368286.1 Mitochondrial translation initiation MRPL39 MRPL36 MRPL37 MRPL34 MRPL35 MRPL32 MRPL33 MRPL4 MRPL41 MRPL3 MRPL42 MRPL2 MRPL1 MRPL40 MRPL9 CHCHD1 MRPS28 MRPS26 MRPS27 MRPS24 MRPS25 MRPS22 MRPS23 MRPL49 MRPS18B MRPS2 MRPS18A MRPL47 MRPL48 MRPL45 MRPS7 MRPL46 MRPS6 MRPS5 MRPL43 MRPS18C MRPL44 MRPL52 OXA1L MRPL53 MRPL50 MRPS9 MRPL51 AURKAIP1 DAP3 MRPS35 MRPS36 MRPL18 MRPS33 MRPL19 MRPS34 MRPL16 MRPS31 MRPL17 MRPL14 MRPL15 MRPS30 MRPL12 MRPL57 MRPL13 MRPL10 MRPL54 MRPL55 MRPL11 MRPL20 ICT1 GADD45GIP1 PTCD3 MRPL27 MRPL28 ERAL1 MRPL23 MRPL24 MRPL21 MRPL22 MRPL30 MTFMT MRPS17 MRPS15 MRPS16 MRPS14 MTIF2 MRPS11 MTIF3 MRPS12 MRPL38 MRPS10 INOSITOL TRANSPORTERS%REACTOME DATABASE ID RELEASE 72%429593 Inositol transporters SLC2A13 SLC5A11 SLC5A3 TYSND1 CLEAVES PEROXISOMAL PROTEINS%REACTOME%R-HSA-9033500.2 TYSND1 cleaves peroxisomal proteins AGPS ACAA1 ACOX1 TYSND1 PHYH SCP2 HSD17B4 DEPOLYMERISATION OF THE NUCLEAR LAMINA%REACTOME%R-HSA-4419969.1 Depolymerisation of the Nuclear Lamina CTDNEP1 CNEP1R1 LMNB1 PRKCA CCNB1 LPIN1 LPIN2 LPIN3 CDK1 EMD LEMD3 LEMD2 PRKCB PKA ACTIVATION%REACTOME DATABASE ID RELEASE 72%163615 PKA activation PRKAR2B PRKAR2A NBEA ADCY4 ADCY3 PRKACG ADCY2 ADCY1 ADCY9 PRKACA ADCY8 PRKAR1B PRKACB ADCY7 ADCY6 PRKAR1A ADCY5 GLUCAGON-TYPE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 72%420092 Glucagon-type ligand receptors GNG11 GNG13 GNB2 GNB1 CYSLTR2 GNB4 GNB3 GNAS GNB5 GNGT1 GNGT2 VIPR1 VIPR2 SCT GLP2R GIP GNG3 GNG2 ADCYAP1 GNG5 GNG4 GNG7 GNG8 ADCYAP1R1 GIPR SCTR GNG10 GLP1R GHRHR GCG GHRH GNG12 VIP PDGFR MUTANTS BIND TKIS%REACTOME DATABASE ID RELEASE 72%9674428 PDGFR mutants bind TKIs PDGFRA DECTIN-1 MEDIATED NONCANONICAL NF-KB SIGNALING%REACTOME DATABASE ID RELEASE 72%5607761 Dectin-1 mediated noncanonical NF-kB signaling PSMD3 CUL1 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 UBA3 UBA52 PSMD10 PSMB11 MAP3K14 PSMD12 UBE2M PSMD11 PSMD14 PSMD13 RELA PSMA7 PSMB10 PSMA8 PSMB6 RELB PSMB7 PSMB4 PSMB5 PSMB2 UBB PSMB3 UBC PSMB1 PSMF1 RPS27A SHFM1 PSMB8 PSMB9 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 CHUK NFKB2 FBXW11 BTRC SKP1 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 ACTIVATED NTRK2 SIGNALS THROUGH FYN%REACTOME DATABASE ID RELEASE 72%9032500 Activated NTRK2 signals through FYN DOCK3 NTRK2 GRIN2B BDNF SRC RAC1 FGFR2 LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 72%190241 FGFR2 ligand binding and activation FGF16 FGF7 FGF18 FGF6 FGFBP1 FGF9 FGFBP2 FGF20 FGFBP3 FGF1 FGF2 FGF23 FGF3 FGF22 FGF10 FGF4 MISCELLANEOUS TRANSPORT AND BINDING EVENTS%REACTOME%R-HSA-5223345.4 Miscellaneous transport and binding events ADD1 NIPA1 NIPA2 DMTN PIP LRRC8C LRRC8D LRRC8A LRRC8B LRRC8E NIPAL4 NIPAL1 NIPAL2 NIPAL3 TUSC3 AZGP1 ANKH MAGT1 MRS2 CTNS MMGT1 PQLC2 ADD3 ADD2 SIGNALING BY BMP%REACTOME%R-HSA-201451.4 Signaling by BMP CHRDL1 SMAD7 ACVR2B ACVR2A FSTL1 SMAD4 SMURF1 ACVRL1 SMURF2 BMPR2 AMHR2 UBE2D1 AMH NOG GDF2 SMAD1 SMAD9 SMAD5 SMAD6 GREM2 BMP2 ZFYVE16 BMPR1B BMPR1A CER1 BMP10 SKI UBE2D3 NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 72%181430 Norepinephrine Neurotransmitter Release Cycle MAOA CPLX1 SLC22A2 RIMS1 BZRAP1 PPFIA1 SLC22A1 PPFIA4 STX1A SLC18A2 VAMP2 PPFIA3 PPFIA2 UNC13B SNAP25 RAB3A SYT1 NOTCH3 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%R-HSA-9013507.1 NOTCH3 Activation and Transmission of Signal to the Nucleus NCSTN ADAM10 APH1B TACC3 YBX1 EGF EGFR UBA52 PSENEN NOTCH3 DLL1 DLL4 NEURL1B UBB JAG2 JAG1 MIB2 MIB1 UBC WWP2 NEURL1 RPS27A PSEN2 PSEN1 APH1A LYSINE CATABOLISM%REACTOME%R-HSA-71064.2 Lysine catabolism CRYM HYKK ALDH7A1 GCDH PIPOX DLST SLC25A21 PHYKPL AASS OGDH DLD AADAT MPS II - HUNTER SYNDROME%REACTOME%R-HSA-2206296.2 MPS II - Hunter syndrome IDS SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE%REACTOME DATABASE ID RELEASE 72%69052 Switching of origins to a post-replicative state PSMD3 CUL1 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 CCNA2 CCNA1 UBA52 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 ANAPC15 ANAPC16 PSMB6 ANAPC7 PSMB7 UBE2C UBE2E1 PSMB4 UBE2D1 ANAPC10 PSMB5 ANAPC11 PSMB2 UBB CDC23 PSMB3 CDC26 CDC27 UBC CDC16 PSMB1 ANAPC4 PSMF1 ANAPC5 ANAPC1 RPS27A ANAPC2 SHFM1 PSMB8 PSMB9 SKP2 PSMC5 PSMC6 PSMC3 ORC5 PSMC4 ORC4 PSMC1 ORC6 PSMC2 ORC1 ORC3 FZR1 ORC2 CDT1 CCNE2 CDC6 CCNE1 MCM7 MCM8 MCM3 MCM4 MCM5 MCM6 MCM2 CDK2 SKP1 PSMD8 PSMD9 PSMD6 RBX1 PSMD7 PSMD4 PSMD5 PSMD2 APEX1-INDEPENDENT RESOLUTION OF AP SITES VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME%R-HSA-5649702.1 APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway PNKP XRCC1 LIG3 OGG1 NEIL2 POLB NEIL1 PENTOSE PHOSPHATE PATHWAY DISEASE%REACTOME%R-HSA-6791465.1 Pentose phosphate pathway disease RPIA TALDO1 TERMINAL PATHWAY OF COMPLEMENT%REACTOME DATABASE ID RELEASE 72%166665 Terminal pathway of complement C7 C9 C8B C8A CLU C8G C5 C6 TRANSCRIPTIONAL REGULATION BY SMALL RNAS%REACTOME%R-HSA-5578749.3 Transcriptional regulation by small RNAs POLR2E POLR2F POLR2H NUP107 NUP188 POLR2K POLR2L NUP62 NDC1 NUP214 SEC13 NUP133 NUP210 NUP93 NUP50 NUP54 POM121 NUP205 AAAS NUP160 TNRC6A NUP85 POLR2A TPR POLR2B POLR2C NUP88 POLR2D NUP43 POLR2G RAE1 POLR2I POLR2J RANBP2 NUP155 NUP153 NUP35 NUPL2 NUP37 AGO1 AGO2 HIST1H2AE HIST1H2AD HIST3H2BB HIST1H2AC HIST1H2AB HIST1H2AJ HIST2H3A HIST1H2BF HIST1H2BE HIST1H2BH HIST1H2BG HIST2H3D HIST1H2BB HIST1H2BA HIST2H3C HIST1H2BD HIST1H2BC H2AFB1 HIST1H3J HIST1H3A HIST1H3F HIST1H3G HIST1H3H HIST1H3I HIST1H3B HIST1H3C HIST1H3D HIST1H3E H3F3B HIST1H4K HIST1H4L H3F3A H2BFS HIST1H4A HIST1H4B HIST1H4H HIST1H4I HIST1H4J HIST1H4C HIST1H4D HIST1H4E HIST1H4F HIST2H2AA3 HIST2H2AA4 HIST2H2AC RAN H2AFJ H2AFZ H2AFX H2AFV HIST2H2BE HIST4H4 HIST1H2BN HIST1H2BM IPO8 HIST1H2BO HIST1H2BJ HIST1H2BI HIST1H2BL HIST1H2BK HIST2H4A HIST2H4B NEPHRIN FAMILY INTERACTIONS%REACTOME%R-HSA-373753.3 Nephrin family interactions CASK CD2AP NPHS1 ACTN1 WASL IQGAP1 ACTN2 PIK3R1 PIK3CB PIK3R2 PIK3CA SPTAN1 SPTBN1 NCK2 KIRREL3 KIRREL FYN KIRREL2 NCK1 MAGI2 ACTN3 ACTN4 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATION FROM THE CENTROSOME%REACTOME%R-HSA-380284.1 Loss of proteins required for interphase microtubule organization from the centrosome HAUS7 CEP70 PRKAR2B CEP72 CEP192 PCNT CEP76 YWHAG CLASP1 CEP78 PLK4 DYNC1H1 ODF2 CEP152 NDE1 NEDD1 FGFR1OP CEP41 OFD1 PPP2R1A PRKACA PLK1 CENPJ CDK1 TUBA4A CEP57 CETN2 TUBA1A CEP164 CCP110 ACTR1A PCM1 HSP90AA1 CNTRL CEP250 NEK2 NINL CEP290 CDK5RAP2 CEP135 TUBB CEP131 HAUS4 HAUS3 HAUS6 CSNK1D HAUS5 CSNK1E TUBG1 DYNLL1 CKAP5 HAUS2 HAUS1 AKAP9 CEP63 MAPRE1 YWHAE SFI1 TUBB4B PAFAH1B1 TUBB4A SDCCAG8 DYNC1I2 DCTN2 SSNA1 DCTN3 HAUS8 SELENOAMINO ACID METABOLISM%REACTOME DATABASE ID RELEASE 72%2408522 Selenoamino acid metabolism RPL26 RPL29 RPL10L RPS4X RPL10A RPL28 RPS3A RPL23A FAU RPL41 SECISBP2 RPL3L AHCY DARS TXNRD1 SARS RPL10 EPRS RPL12 AIMP1 RPL13A RPL11 AIMP2 KARS RPS3 QARS RPL14 LARS RPL13 RARS RPS2 PSTK RPL15 MARS RPL18 RPL17 IARS RPL19 EEF1E1 RPL27A CTH NNMT RPS9 RPS7 RPS8 SCLY RPS5 RPS6 RPSA RPS15 EEFSEC RPS14 RPS17 RPS16 RPS19 RPL18A RPL36AL RPS18 RPLP1 RPS11 RPS10 RPLP0 RPS13 RPS12 RPLP2 RPL7A MAT1A CBS RPS27L INMT UBA52 RPL37A RPS26 RPS25 RPS28 RPS27 RPL36A RPS29 RPS20 RPL35A RPS21 RPS24 RPS23 RPL22L1 HNMT RPS4Y2 RPS4Y1 RPS27A RPL26L1 RPL4 RPL39L RPL5 RPL30 RPL3 RPL32 RPL31 RPL34 RPL8 RPL9 RPL6 RPL7 RPL36 RPL35 RPL38 RPL37 PAPSS2 RPL39 PAPSS1 RPS15A RPL21 RPL23 SEPSECS RPL22 GNMT RPL24 RPL27 DISEASES OF PROGRAMMED CELL DEATH%REACTOME DATABASE ID RELEASE 72%9645723 Diseases of programmed cell death CAST BCL2L11 CDC25C CDC25B LMNB1 FOXO3 GOLGA2 CAPNS1 CAPNS2 CDK5 CAPN2 CAPN1 CDK5R1 PRDX2 SOD2 FASLG PRDX1 YWHAE APP JUN CDC25A CDKN2A C1QBP RNA POLYMERASE II TRANSCRIPTION%REACTOME DATABASE ID RELEASE 72%73857 RNA Polymerase II Transcription CUL1 MEN1 GLI3 GLI2 CPSF4 CPSF7 CPSF1 CSTF3 CPSF3 CSTF2 CPSF2 CSTF2T WDR33 NUDT21 FIP1L1 PABPN1 CLP1 PCF11 PAPOLA CSTF1 SYMPK ITCH ZNF350 BMI1 RNF2 TRIM28 CTSV CBX8 PHC2 CTSL PHC1 RING1 CTSK CBX4 CBX2 PCGF2 PHC3 FOXO1 CTDP1 NCBP1 NCBP2 SUPT4H1 SUPT5H GTF2F1 GTF2F2 POLR2A POLR2B POLR2C FOXO3 POLR2D POLR2G NELFB NELFA NELFCD POLR2I POLR2J NELFE PHAX PPARGC1A SNRPD3 PPARGC1B SNRPG SNRPE SNRPF SNRPB KIT ESR2 OPRK1 IHH KRAS SOX2 AR SOX9 RORA RSPO3 RB1 WDR61 MYC LEO1 CDKN2B SKP2 MAX FKBP5 CDC7 TCF7 CDC73 EGFR LEF1 CEBPB TCF7L1 E2F5 NOP2 E2F6 HSPD1 ZFHX3 TGFB1 SMARCB1 RXRG SMAD4 SMURF1 HDAC10 RUNX3 EPC1 SMARCC1 SMARCC2 VENTX AFF4 CTR9 MLLT1 RTF1 VEGFA MLLT3 SUPT6H SETD1B IWS1 EAF1 SETD1A EAF2 BLM PAF1 SMARCA2 PCNA SMARCA4 CBX6 RPA1 RPA2 WRN RPA3 DNA2 ASH2L PRMT6 CCNC PBRM1 ACTL6B RELA TNFRSF18 YEATS4 TFAP2B CCND1 ARID2 KMT2E KMT2D KMT2A KMT2C KMT2B TCF7L2 ESR1 KCTD6 NFKB1 KLF4 CDK4 NOTCH2 NOTCH3 KDM5B NOTCH4 ZNF287 DPY30 ZNF17 ZNF18 WDR5 ZNF285 ZNF19 ZNF282 ZNF10 ZNF12 ZNF14 RXRB ZNF28 RXRA PRR5 ARID1A ZNF274 ARID1B ZNF273 ZNF20 ZNF23 SMARCD1 ZNF25 ZNF26 SMARCD2 ZNF268 ZNF267 HDAC8 ZNF266 RBBP5 ZNF264 SMARCE1 ZNF263 ZNF34 ZNF30 AKT2 ZNF257 AKT3 ZNF256 MYB ZNF496 MLST8 PGR ZNF254 GATA3 ZNF253 ZNF493 POU2F1 ZNF492 ZNF250 AXIN1 UCMA CITED1 ZNF490 PRKCB ZNF43 PDPK1 ZNF45 ZNF41 ZNF248 ZNF486 ZNF485 L3MBTL2 ZNF484 UXT ZNF483 YAF2 ZNF480 PCGF6 ZNF479 CBX5 ZNF235 MGA ZNF234 RYBP ZNF233 WWOX ZNF230 TFAP2D ZNF471 TFAP2E ZNF470 CCND3 MAPKAP1 CITED4 HTT CCND2 ZNF227 CDK6 ZNF468 ZNF226 ZNF225 ZNF224 ZNF223 ZNF222 ZNF461 ZNF460 RICTOR ATAD2 ZNF77 ZNF79 ZNF70 ZNF71 ZNF74 ZNF699 ZNF215 ZNF214 VDR ZNF697 ZNF213 CAV1 ZNF454 ZNF696 MTOR ZNF212 ZNF211 ZNF692 ZNF691 LSM10 ZNF208 LSM11 ZNF205 ZNF689 CTNNB1 ZNF446 ZNF688 ZNF445 ZNF202 ZNF443 ZNF442 ZNF200 ZNF684 ZNF441 ZNF440 ZNF682 ZNF681 ZNF680 ZFP69B MAF ZNF439 ZNF679 ZNF436 ZNF678 ZNF473 ZNF677 ZNF676 ZNF433 ZNF675 ZNF432 PVALB ZNF431 ZNF430 ZNF671 ZNF670 DLX5 DLX6 MOBP INS ZKSCAN7 ZNF429 ZKSCAN8 ZKSCAN3 ZNF669 FAS ZNF426 TNFRSF10B ZNF668 FASLG ZNF425 ZKSCAN5 TNFRSF10A ZNF667 ZKSCAN4 ITGA4 ZNF665 ZNF664 ZKSCAN1 ZNF662 ZNF660 ZNF419 ZNF418 ZNF417 ZNF416 ZNF658 ZNF415 SP7 ZNF655 ZNF649 DGCR8 NKX3-2 ZNF641 HAND2 PPM1D ZNF627 ZNF626 ZNF625 ZNF624 MED1 ZNF621 ZNF620 ZNF860 ZNF619 ZNF616 ZNF615 MED8 ZNF614 ZNF613 ZNF611 MED4 ZNF610 MED6 ZNF729 MED7 ZNF727 ZNF726 ZNF721 ZNF720 ZFP1 ZFP2 ZNF716 BCL2L11 ZNF713 ZNF711 ZNF710 KCTD15 ZNF324B ZNF709 ZNF708 ZNF707 ZNF706 ZNF704 ZNF703 ZNF701 HIVEP3 ZNF700 ITGBL1 ZFP14 ZNF585B ZNF585A ZFP28 PRDM7 MSX2 ZNF99 ZNF92 GPRIN1 RBM14 ZNF804B ZNF175 ZSCAN32 FOXO6 ZNF169 FOXO4 ZNF705G ZNF705D NR4A1 ZNF160 ZNF705A ZSCAN25 ZNF157 ZNF398 ZNF155 ZNF154 ZNF394 ZNF383 ZNF141 ZNF382 ZNF140 ZNF37A ZNF138 ZNF136 ZNF135 ZNF133 ZNF124 ZIK1 BRD2 ZNF724P ZNF599 ZNF114 GPS2 ZNF597 ZNF596 ZNF112 ZNF347 ZNF589 ZNF587 ZNF586 ZIM2 ZNF343 ZIM3 ZNF101 ZNF584 ZNF100 ZNF583 YES1 ZNF582 IL6 ZNF33B ZNF33A ZNF337 ZNF577 ZNF334 ZNF333 ZNF331 ZNF573 ZNF571 ZNF570 ZFP30 ZNF569 ZNF568 ZNF567 ZNF324 ZNF566 ZNF565 SMAD7 ZFP37 ZNF564 ZNF563 MYL9 ZNF562 ZNF320 ZNF561 ZNF560 ZNF317 ZNF559 ZNF558 ZNF557 ZNF799 ZNF556 ZNF555 ZNF554 ZNF311 CRH ZNF552 ZNF551 ZNF793 ZNF550 DDIT3 ZNF792 ZNF791 ZNF790 KRBA1 KRBOX4 ZNF549 ZNF548 ZNF547 ZNF304 ZNF546 ZNF786 ZNF302 ZNF544 ZNF785 ESRRA ZNF543 ZNF300 ZNF782 ZNF540 ZFP69 CDK8 ZNF778 ZNF777 ZNF776 ZNF775 ZNF774 ZNF773 ZNF530 ZNF772 ZNF771 BGLAP ZNF770 TXNIP ZNF529 ZNF528 ZNF764 ZNF521 ZNF75D ZFP90 ZNF75A ZNF519 ZNF517 ZNF514 ZNF510 ZNF750 ZNF749 ZNF506 ZNF747 SMARCD3 ZNF746 ZNF500 ZNF740 ZNF738 ZNF737 ZNF736 ZNF735 ZNF732 ZNF730 ZNF607 ZNF606 ZNF605 ZNF600 ZNF839 HKR1 TWIST2 ZNF2 ZNF3 ZNF354A ZNF354C ZNF354B KCTD1 SMAD6 ZNF197 ZNF195 ZNF286A ZNF189 ZNF184 ZNF180 NOTCH1 MAML2 MAML1 HNF4G RBPJ THRB HES1 NR2C1 NR4A2 NR5A1 SNW1 MAML3 MAMLD1 THBS1 RARG RARA RARB TBL1X ITGAL RORC TBL1XR1 LGALS3 CSF1R TWIST1 RBFOX1 SLC2A3 MDC1 CCNK TP53RK MT-CO1 EHMT1 STUB1 NOC2L GLS TP53AIP1 KAT5 CHEK2 CHEK1 PIP4K2A PIP4K2B PIP4K2C TP63 DAXX PRKAB2 HUS1 PRKAB1 OPRM1 RRAGA COX7A2L SCO1 RRAGC SCO2 RRAGB DDIT4 RRAGD MT-CO2 MT-CO3 TP53 RHNO1 L3MBTL1 MEAF6 TXN PRDX2 NUAK1 BRIP1 PCBP4 PRDX1 TP53BP2 SFN ATRIP BANP BARD1 PLK3 POMC JUN PRELID1 SURF1 CREBBP CR1 CRADD GADD45A PLK2 TPX2 MOV10 AGO3 AGO4 AGO1 AGO2 RAD17 ATM CDK12 CDK13 TP73 ATR CDKN1A BTG2 COX7B CDKN1B ELL SETD8 SETD9 PHF20 PRKAG1 CHM PRKAG2 BRCA1 COX7C PRKAG3 BBC3 IL3 TAF7L RPTOR ING5 ING2 AIFM2 CASP10 TNKS1BP1 COX8A PRMT5 BRD1 RMI2 CNOT6L PRMT1 RMI1 ITGA2B TOP3A DDB2 RAD51D TCEB3CL2 COX5B COX5A PLAGL1 PERP TCEB3 PMS2 NR2E1 TCEB2 TCEB1 COL1A1 TCEB3CL TAF9B BID BRD7 TIGAR NPM1 CDKN2A MRE11A SPI1 COX6C CLDN5 MLH1 HIPK1 ZFPM1 GATA2 POU4F1 GATA1 LRPPRC NFE2 POU4F2 NFATC2 HIPK2 CTLA4 TTC5 CENPJ TAL1 YAP1 CCNG1 SERPINB13 TCEA1 PCGF5 LAMTOR2 RAD1 CSF2 LAMTOR1 LMO1 LAMTOR4 LMO2 FOXP3 LAMTOR3 SOCS4 LAMTOR5 AUTS2 STEAP3 CCNT2 IL2 CCNT1 NR4A3 TACO1 TCF3 PRDM1 LDB1 IL2RA COX6A1 STK11 SESN3 SESN2 NBN BNIP3L G6PD SUPT16H USP7 IGFBP3 USP2 TSC2 TSC1 CDC25C STAT1 COX6B1 MSH2 CCNE2 FANCD2 CCNE1 KAT6A MAPKAPK5 COX16 COX18 AK6 NDRG1 SMYD2 COX11 PMAIP1 COX14 SLC38A9 BCL2L14 MAP2K6 ZNF420 FANCI SLMO1 BRPF1 BRPF3 TNFRSF10C FANCC CNOT10 TNFRSF10D CNOT4 PPM1A CDK9 CNOT6 CNOT7 RGCC TP53I3 BCL6 CNOT11 CNOT1 RHEB CNOT2 CNOT3 JMY CDK2 MDM2 TAF4B CYCS PIN1 MDM4 CNOT8 RAD9B COX20 RAD9A YWHAE DYRK2 PPP1R13B COX4I1 PTEN TRIAP1 PIDD1 YWHAQ CASP6 PPP1R13L EXO1 CASP1 CASP2 TCEB3C TOPBP1 TCEB3B YWHAG ZNF385A YWHAH RFC5 GPX2 RFC3 RFC4 APAF1 RFC2 PPP2R5C RABGGTB RABGGTA RBL2 CCNA2 CCNA1 TFDP1 RBL1 TFDP2 RRM2B BIRC5 TMEM219 TMEM55B PRKAA1 RNF34 PRKAA2 CSNK2A1 GLS2 TAF9 TAF1L CSNK2A2 NLRC4 AURKB AURKA TP53INP1 E2F1 RBBP8 E2F4 RFFL E2F7 E2F8 CSNK2B TAF15 TAF12 TAF13 NDUFA4 TAF10 TXNRD1 MMP13 TAF11 ARID3A SSRP1 PML TNRC6C RAD50 CARM1 RQCD1 BAX TAF7 TAF6 SPP1 TAF5 TAF4 TAF3 TAF2 TNRC6A TNRC6B TAF1 FZR1 TGFA BMP2 GPAM SIRT3 SOD2 CAMK4 ANAPC15 ANAPC16 ANAPC7 UBE2C UBE2E1 UBE2D1 ANAPC10 SOCS3 ANAPC11 CCNB1 GP1BA CDC23 CDC26 CDC27 CDC16 CDK1 ANAPC4 ANAPC5 ANAPC1 ANAPC2 PF4 HDAC3 GTF2B GTF2A1 GTF2A2 RNMT GTF2E1 GTF2E2 RNGTT GPI PPP2R1B PPP2R1A PRKACA GRIN2A INTS1 INTS3 INTS2 INTS5 G6PC INTS4 INTS7 INTS6 INTS9 INTS8 GRIN2B INTS12 INTS10 ICE1 ICE2 SSU72 NABP2 NABP1 TAF8 ELL2 ELL3 ZC3H8 SERPINE1 RPRD2 NPPA SKIL RPAP2 TGIF1 ASUN TGIF2 VWA9 USP9X CPSF3L ATP1B4 RPRD1B SKI RPRD1A TRIM33 POU2F2 PPP2CA MED16 PPP2CB MED15 MED17 MED12 PCK1 MED14 MED13 MED10 SATB2 GATA4 GCK MED27 NKX2-5 MED26 WWTR1 MED23 MED25 MED24 MED20 GAD1 PPARG GAD2 PPARA PPARD SUMO1 BLK ELF1 ELF2 CBFB PAX5 RUNX1 TBX5 ATF2 CHD4 EP300 JUNB MEF2C MET MED30 TCF12 FOS MED31 CREB1 SGK1 SP1 MAPK1 EIF4A3 MAPK3 CASC3 MAGOH THOC1 THOC3 MAPK14 THOC2 THOC5 MAPK11 THOC7 CDC40 THOC6 CDK5 SRRM1 DDX39A DDX39B ZC3H11A SARNP SRSF2 SRSF3 CDK5R1 SRSF4 SRSF5 SRSF6 SRSF7 SLU7 SRSF9 MYBL2 FYTTD1 LUZP4 RBM8A POLDIP3 SRSF1 U2AF1 ERBB2 U2AF1L4 U2AF2 DHX38 SRSF11 CHTOP UPF3B MAGOHB RNPS1 SMAD1 CAMK2B GRIA2 CAMK2D CAMK2A APOE CAMK2G TEAD4 CTGF TEAD1 TEAD2 TEAD3 IFNG UBE2I SRRT RNF111 CCNH EHMT2 SNAPC5 RRM2 SNAPC1 SNAPC2 SLBP SNAPC3 SNAPC4 ZNF143 HIST1H2AE HIST1H2AD HIST3H2BB HIST1H2AC HIST1H2AB HIST1H2AJ HIST2H3A HIST1H2BF PRKCQ HIST1H2BE HIST1H2BH HIST1H2BG HIST2H3D HIST1H2BB HIST1H2BA HIST2H3C GAMT HIST1H2BD TJP1 HIST1H2BC H2AFB1 OCLN ITGA5 HIST1H3J HIST1H3A HIST1H3F PARP1 HIST1H3G ACTL6A HIST1H3H HIST1H3I HIST1H3B HIST1H3C HIST1H3D HIST1H3E H3F3B HIST1H4K CBX3 UBE2D3 HIST1H4L H3F3A H2BFS HIST1H4A CDK7 HIST1H4B CGA HIST1H4H HIST1H4I HIST1H4J HIST1H4C MNAT1 HIST1H4D HIST1H4E NR1D1 EZH2 HIST1H4F HIST2H2AA3 YY1 GSK3B HIST2H2AA4 NEDD4L CHD3 HIST2H2AC SIN3B H2AFJ SIN3A TBP EED H2AFZ NCOR2 H2AFX NCOR1 H2AFV SIRT1 HIST2H2BE ABL1 KAT2B KAT2A HIST4H4 BTG1 HIST1H2BN MSTN HIST1H2BM IGFBP1 HDAC2 SREBF1 HIST1H2BO TRIM63 NR1H2 HIST1H2BJ CAT HDAC1 FOXG1 RETN HIST1H2BI ATXN3 HIST1H2BL NPY HIST1H2BK PLXNA4 ABCA6 HIST2H4A FBXO32 PINK1 HIST2H4B CCNG2 AGRP RBBP4 POLR2E POLR2F POLR2H RBBP7 MTA2 POLR2K POLR2L MBD3 SUZ12 GTF2H1 DEK WWP1 GTF2H2 GTF2H3 GTF2H4 GATAD2B GTF2H5 GATAD2A ERCC3 ERCC2 RAD51 LBR PTPN4 IRAK1 TFAP2A TFAP2C CITED2 PITX2 YWHAB PSMD8 PSMD9 PSMD6 SRC PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 AKT1 PSMD1 TRPC3 YWHAZ PTPN11 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 SMAD2 UBA52 SMAD3 PSMD10 PSMB11 BDNF PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 SMURF2 PSMB4 PSMB5 PSMB2 UBB PSMB3 THRA RORB UBC PSMB1 NR2C2 PSMF1 HNF4A NR2C2AP RPS27A ESRRB NR2F1 NR1D2 ESRRG NR0B2 SHFM1 NRBP1 NR2F6 PSMB8 PSMB9 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 NR3C1 NFYA NFYB NFYC PTPN1 HDAC11 HEY1 HEY2 HDAC4 HDAC5 DLL1 HDAC9 HDAC6 HDAC7 JAG1 LIFR SKP1 RBX1 SST RET SIGNALING%REACTOME DATABASE ID RELEASE 72%8853659 RET signaling PRKCA FRS2 PTPN11 DOK1 PIK3CD NRTN GFRA1 RAP1GAP SHC1 GFRA2 GAB1 GFRA4 PIK3R1 PIK3R2 PIK3CA PLCG1 SOS1 PRKACG DOK4 DOK5 PRKACA PSPN DOK6 PRKACB GDNF ARTN PDLIM7 PIK3R3 IRS2 GRB10 GAB2 PIK3CB GRB7 RET GFRA3 DOK2 MAPK7 SHC3 PHASE I - FUNCTIONALIZATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 72%211945 Phase I - Functionalization of compounds CYP3A43 ARNT2 NQO2 ALDH1A1 ALDH3A1 CYP1A2 CYP1A1 ALDH1B1 EPHX1 CYP2D6 ALDH2 CYP4F2 CYP4F3 CYP4F8 CYP4V2 CYP8B1 CYP2E1 PTGIS CYP3A4 CYP3A5 AOC3 BPHL AOC1 CYP3A7 AOC2 FMO1 FMO2 FMO3 CYP51A1 AHR NCOA1 POMC CYP2B6 CYB5R3 NCOA2 CYP21A2 AIP RXRA CYP2C9 CYP2A13 CYP2C8 CYP4F22 CYP4A22 CYP4F11 POR CYP4F12 CYP2U1 CYP4A11 CYP46A1 PTGS1 CYP11A1 ACSS2 CYP2F1 ACSS1 CYP2S1 CYP2C19 CYP2C18 AADAC CYP11B2 CYP11B1 CYP7B1 ADH1C ADH1B ADH1A ADH7 CYP19A1 ADH5 TBXAS1 ADH6 CYP7A1 CMBL ADH4 CYP26A1 CYP27A1 CYP27B1 CYP26B1 CYP24A1 CYP26C1 CYP2R1 MAOB MAOA CBR3 HSP90AB1 PAOX PTGES3 MARC2 CYP2W1 MARC1 ARNT CYP2A7 CYP2A6 AHRR CYP4B1 FDXR CYP1B1 CYP2J2 CYP3A7-CYP3A51P NR1H4 CYP39A1 FDX1 CES3 CYB5B FDX1L CES2 CES1 GPCR DOWNSTREAM SIGNALLING%REACTOME DATABASE ID RELEASE 72%388396 GPCR downstream signalling GRM7 GRM6 PRKAR2B GPER1 GRM8 PRKAR2A QRFPR SSTR1 SSTR2 SSTR4 SSTR5 HTR6 CNR2 HTR7 GNAS CNR1 HTR1E TAS1R2 HTR1F TAS1R1 HTR1D TAS1R3 HTR2B CCK HTR1A OPN1SW HTR1B HTR2C RXFP4 HTR2A GRPR HTR4 RXFP3 HTR5A PROK2 PROK1 GNA14 TRHR ADCY4 GNA15 GALR3 ADCY3 GALR2 GALR1 ADCY2 ADCY1 ADCY8 GNA11 ADCY7 GPR183 ADCY6 PNOC ADCY5 GPR132 OPN1LW GAST OPN1MW RGR GPR4 HCAR2 GPR143 HCAR3 DGKG HCAR1 DGKE CHRM1 DGKD DGKB CHRM4 LRAT DGKA CHRM5 GUCA1B GUCA1A GUCA1C ABHD12 HSPG2 DGKZ MTNR1A MTNR1B DGKQ DGKK RBP4 PPEF1 DGKI RBP2 DGKH ABHD6 RBP1 PPP3CC STRA6 DAGLA TRH PPP3R1 INSL5 DAGLB RCVRN METAP1 METAP2 NMT1 OXTR RRH AVP EDNRA EDNRB UTS2R RETSAT GPR37L1 UTS2B PTGFR NMT2 PPY NTSR1 NTSR2 NMB NMBR NMS NMU QRFP BRS3 CCKAR FFAR3 FFAR2 EDN1 EDN2 EDN3 AVPR1B AVPR1A CCKBR NPB GUCY2D PTGER1 GPIHBP1 PTGER3 HRAS GUCY2F NPW KISS1R F2RL1 F2RL2 F2RL3 CCL4L2 PMCH NPY2R NRAS SDR9C7 GHSR NPY1R RGS9BP APLNR SUCNR1 NTS OPN4 OPN3 C3 OPN5 PYY NMUR2 NMUR1 GPSM1 TAS2R7 GPSM2 TAS2R9 TAS2R8 MLNR HEBP1 PDE4B BDKRB2 BDKRB1 TAS2R1 TAS2R3 GPSM3 TAS2R5 TAS2R4 NPY5R CORT RGS18 RGS14 RGS13 NPY4R OPRL1 GNA12 RGS21 S1PR3 RGS22 S1PR2 S1PR5 S1PR4 OPRK1 KISS1 RGS10 RGS12 HRH1 HRH3 HRH4 PIK3CG PIK3R1 EGFR PIK3CA SOS1 LRP1 PPP3CA PPP3CB ARHGEF18 RHOA LRP2 LRP8 CXCL8 PIK3R3 FFAR4 PIK3R6 PIK3R5 GPR17 LTB4R2 LTB4R GRP P2RY1 GPC1 GPC3 AHCYL1 GPC2 GPC5 GPC4 GPC6 AKR1C1 AKT2 AKR1C3 AKT3 AKR1C4 CXCL12 PPP1CA PTAFR VAV3 PRKCB PDPK1 VAV1 VAV2 ROCK1 ROCK2 CCR5 ITPR1 ITPR2 CXCR4 ITPR3 PIK3R2 CDC42 PAK1 TRIO ITSN1 PREX1 ARHGEF40 OBSCN NGEF ARHGEF26 CLPS KALRN ABR ECT2 ARHGEF33 ARHGEF35 ARHGEF37 ARHGEF39 ARHGEF38 NET1 RASGRF2 ARHGEF10L AKAP13 MCF2L RASGRP2 ARHGEF11 ARHGEF10 VIPR1 RASGRP1 ARHGEF12 VIPR2 SCT PLEKHG2 ARHGEF15 RXFP1 ARHGEF17 RXFP2 PLEKHG5 ARHGEF16 CYSLTR1 ARHGEF19 GPR176 ARHGEF9 ARHGEF3 PTGDR LHCGR ARHGEF4 TAAR8 ARHGEF1 TAAR9 ARHGEF2 TAAR6 TAAR5 SOS2 ARHGEF5 TAAR2 TAAR1 ADCYAP1 PLCB3 PLCB4 FGD1 PLCB1 FGD2 IAPP ADCYAP1R1 PLCB2 FGD3 CALCA GNA13 FGD4 CALCRL CALCB GIPR MCF2 GPR83 ADRB1 GPR84 ADRB2 CRHR1 CRHR2 GHRHR MC2R CALCR HRH2 DRD1 DRD5 GPR15 MC1R RLN2 RLN3 GPR27 GPR25 ANXA1 AGT GPR20 ADM PTH1R MC4R CHRM3 INSL3 GPR39 FSHB GPR32 AVPR2 GLP2R GPBAR1 PTH2R GIP MC3R ADORA2A ADRB3 ADORA2B FSHR CRH NPSR1 PTGER4 RAMP2 RAMP3 GPR45 PTH PTGER2 PRKX PTH2 PTHLH NPS GPR150 PSAP GPHA2 P2RY11 SCTR TSHR GHRH ADM2 MC5R VIP RAMP1 GPHB5 C3AR1 ADRA2C ADRA2A FPR1 FPR2 AKR1B10 FFAR1 TACR2 TACR3 TAC3 TACR1 TAC1 DRD3 DRD4 PPBP OPRD1 CYP4V2 TSHB SLC24A1 PDE6G MMP3 CNGA1 RHO OPRM1 SAG PDE6B PDE6A CNGB1 S1PR1 CXCR1 CXCR2 POMC C5AR1 C5 CXCL1 P2RY12 P2RY13 P2RY10 P2RY14 LPAR4 P2RY6 P2RY4 LPAR6 ADORA3 P2RY2 ADORA1 ARRB2 ADRA1D ADRA1B ADRA1A KPNA2 CXCL6 CXCL9 CXCL3 CXCL13 CXCL2 CX3CL1 CXCL5 CXCL16 CCR9 CCR8 CCR7 CCR6 CCR4 CCR3 CCR2 XCL2 XCL1 CX3CR1 CCL13 PLB1 CXCR5 CXCR6 APP CCL5 CXCR3 CCL4 ARRB1 CCL1 CCL19 CCL16 CCR10 CCL25 CCR1 SSTR3 XCR1 CCL21 CCL20 CXCL10 CXCL11 ACKR3 MCHR1 CCL28 CCL27 PLA2G4A MGLL HBEGF AWAT2 CAMK4 KNG1 GNAT2 GNAT3 GNAT1 F2R RGS9 RGS6 F2 RGS7 GNAZ PF4 GNG10 GNG12 GNG11 GNG13 GNAO1 GNB2 GNB1 GNB4 GNB3 GNB5 GNGT1 GNGT2 GNAI3 GNAI1 GNAI2 GNG3 GNG2 CHRM2 GNG5 GNG4 GNG7 GNG8 AGTR1 PLXNB1 RGS11 PPP2R1B PPP2R1A PRKACG PRKACA PRKACB RDH11 PPP2R5D PPP2CA PPP2CB OR11H2 OR11H1 OR2M7 OR11H4 OR2M5 OR2M4 OR2M3 OR1K1 OR2M2 OR4K17 CAMKK1 OR4Q3 CAMKK2 OR2AE1 OR11H6 OR2L8 OR1J4 OR11G2 OR2L5 OR1J2 OR2L3 GABBR2 OR1J1 OR2L2 GABBR1 OR4P4 OR10AD1 OR5R1 OR6T1 OR4K15 OR4K14 OR4K13 OR13J1 OR1I1 OR2K2 OR6S1 OR5M11 OR5M10 OR10D3 OR8B12 OR14K1 OR2J3 OR4N5 OR2J2 OR4N4 OR2J1 OR4N2 OR5P3 OR5P2 OR10C1 OR10J1 OR11L1 OR10J3 OR10J5 AGRN OR5W2 OR6Y1 OR52B2 OR52B6 OR1N2 OR1N1 OR5V1 OR6X1 OR52A1 OR52A5 OR10H1 OR10H3 OR10H2 OR10H5 OR10H4 OR1M1 OR4S2 GNAL DHRS3 OR4S1 ADRBK2 OR2AG1 NBEA OR2AG2 DHRS9 OR10G2 RDH10 OR14A16 RDH16 GRM1 OR1L8 OR10G4 RDH5 GRM5 OR1L6 OR10G3 OR1L4 OR1L3 OR1L1 OR5T3 OR5T2 OR5T1 RPS6KA3 OR6V1 OR10G6 OR10G8 RPS6KA2 OR10G7 RPS6KA1 OR10G9 OR52W1 OR1S2 OR1S1 OR13D1 OR14C36 OR5AS1 OR2T8 OR2T7 OR2T6 OR2T5 OR2T4 OR2T3 OR2T2 CREB1 OR13C9 OR2T1 OR13C8 OR4X2 OR2L13 OR4X1 OR9A4 OR51T1 OR9A2 OR13C3 MAPK7 OR13C2 MAPK1 OR13C5 OR13C4 MAPK3 OR5AR1 OR2S2 OR1Q1 ABCA4 OR51S1 OR4A47 OR5B21 REEP1 REEP5 REEP4 CDK5 REEP3 REEP2 REEP6 OR13A1 OR7E24 OR7A10 OR14J1 OR13H1 OR2Y1 OR56B1 OR8D4 OR8D2 OR56B4 OR8D1 OR7A17 OR6C70 OR6C76 OR6C75 OR6C74 OR13G1 OR14I1 OR10A7 OR56A5 TBXA2R OR7A5 OR10A2 OR10A4 OR56A4 OR10A3 OR56A3 OR10A6 OR10A5 OR56A1 RGS17 OR6C65 RGS19 OR2W3 RGSL1 OR8B8 RGS16 OR2W1 RGS4 OR8B4 RGS20 PRKCH OR8B3 OR6C68 OR13F1 OR8B2 OR12D3 OR12D2 OR5AU1 OR51V1 OR2V2 OR2V1 OR11A1 OR8A1 OR7G2 OR8I2 OR7G1 OR9K2 OR52N1 OR52N5 OR52N4 CAMK2B OR52N2 OR51L1 SDC4 CAMK2D SDC2 OR5D18 CAMK2A SDC3 OR10W1 OR2A42 OR5D16 OR5B3 APOM OR5B2 OR5D14 OR8H3 APOE OR5D13 CAMK2G APOB OR8H2 OR8H1 OR52M1 OR10V1 PRKCG OR4C12 OR2AT4 OR6C6 OR4C11 OR6C4 OR5A2 OR8G5 OR6C3 OR4C16 OR5AK2 OR5A1 SDC1 OR6C2 OR4C15 OR6C1 OR4C13 OR8G1 OR9I1 OR10T2 OR51J1 OR52L1 OR7D4 OR6B3 OR6B2 OR6B1 OR7D2 OR2A25 OR51I2 OR10S1 OR52K2 OR51I1 OR52K1 PDE3A OR4D11 OR2Z1 OR4D10 OR2A12 OR6A2 OR9G4 OR7C2 HSD17B1 OR7C1 OR9G1 OR2A14 OR2A1 OR4E2 OR51Q1 GCG OR4D9 OR5AP2 OR5B12 OR4D6 OR4D5 OR5B17 OR4D2 OR4D1 OR5F1 OR10Z1 OR52R1 OR4C6 OR4C5 OR3A3 OR3A2 OR4A15 OR4C3 OR14A2 OR3A1 OR4A16 OR8K5 OR8K3 OR8K1 OR5AN1 OR4B1 OR4C46 OR8J3 OR6F1 OR8J1 OR51M1 OR10X1 OR4A5 OR7G3 OR5C1 OR1C1 OR5K4 OR5K3 OR5K2 OR51D1 OR5K1 OR6M1 OR2T12 OR2T10 OR2T11 OR5H15 OR5H14 PDE8B PDE8A OR2D3 OR2D2 OR1B1 GNAQ OR52E4 OR5J2 OR52E2 OR5AC2 OR52E8 OR52E6 OR52E5 OR2C3 OR1A2 OR6K6 OR1A1 OR2C1 OR51B2 OR6K3 OR6K2 OR5I1 OR52D1 OR9Q2 OR9Q1 OR2AK2 GRK5 GRK6 OR51B6 OR51B5 OR51B4 OR2B6 OR4F6 OR4F5 OR5H6 OR2B3 OR10K2 OR4F4 OR2B2 OR10K1 OR4F3 OR5H2 OR5H1 FNTA OR6J1 OR2AJ1 OR51A4 OR2A7 OR51A2 OR2A5 OR2A4 OR51A7 OR2A2 RTP4 RTP5 OR52J3 RTP2 OR51H1 RTP3 PRKCQ RTP1 OR1G1 OR4M2 OR4M1 OR10R2 OR10AG1 OR6Q1 OR8U1 PDE4A OR51G2 OR52I2 OR51G1 OR52I1 OR1F1 PDE4D OR2H2 PDE4C OR2H1 OR4L1 OR10Q1 OR6P1 OR2B11 OR2AP1 OR51F2 OR2G6 OR51F1 OR5M9 OR52H1 OR5M8 OR2G3 OR1E2 OR4K5 CGA OR2G2 OR1E1 OR5M3 OR4K2 OR4K1 OR5M1 OR10P1 OR2T34 OR8S1 OR2T35 OR2T33 OR4F29 OR4F21 OR1D5 OR2T27 OR51E1 OR1D2 OR2F2 OR2F1 OR2T29 OR51E2 OR5L2 OR6N2 OR5L1 OR6N1 OR4F17 OR4F16 OR4F15 PDE7B PDE7A LDLR NPY CYSLTR2 APOA2 APOA1 APOA4 TTR BCO2 BCO1 APOC3 APOC2 SAA1 PDE1B PDE1A PDE2A PDE11A PDE10A PRKCE SRC TIAM2 TRPC7 AKT1 PTGIR TRPC6 TRPC3 PRKCD PRKCA ARHGEF7 LHB RHOC RHOB TIAM1 PDE1C ADRBK1 PDYN RBP3 AGTR2 FPR3 RDH12 NPBWR1 NPBWR2 HCRT NAPEPLD GPR18 GPRC6A PDE3B GPR37 GPR31 PROKR1 PROKR2 GPR55 GPR68 GPR65 FNTB UTS2 RLBP1 HCRTR2 HCRTR1 APLN OPN1MW2 NPFFR2 NPFFR1 TAS2R20 OXER1 TAS2R10 NPFF TAS2R13 TAS2R14 TAS2R16 MYO7A TAS2R19 TAS2R40 TAS2R41 TAS2R42 TAS2R43 TAS2R46 LPAR1 LPAR2 LPAR3 PENK TAS2R30 TAS2R31 TAS2R38 TAS2R39 RPE65 LPAR5 PPP1R1B GNRH2 GNRH1 PNLIP TAS2R60 PTGDR2 MLN GNRHR OXGR1 LPL TAS2R50 GAL HSD17B6 RGS5 RGS2 RGS3 RGS1 RGS8 CASR CAMKMT PCP2 ARHGEF25 MCHR2 GRK1 BTK ARHGEF6 GRK7 LRP10 OXT LRP12 GRM3 ADCY9 GLP1R PRKAR1B PRKAR1A GRM2 SST GRM4 DEFECTIVE SLC2A1 CAUSES GLUT1 DEFICIENCY SYNDROME 1 (GLUT1DS1)%REACTOME DATABASE ID RELEASE 72%5619043 Defective SLC2A1 causes GLUT1 deficiency syndrome 1 (GLUT1DS1) SLC2A1 GP1B-IX-V ACTIVATION SIGNALLING%REACTOME DATABASE ID RELEASE 72%430116 GP1b-IX-V activation signalling FLNA GP9 PIK3R1 VWF GP1BB RAF1 YWHAZ GP1BA GP5 TRANSCRIPTIONAL REGULATION BY RUNX2%REACTOME DATABASE ID RELEASE 72%8878166 Transcriptional regulation by RUNX2 CUL1 GLI3 HIVEP3 GLI2 ITGBL1 MSX2 WWP1 LGALS3 RBM14 TWIST1 CCND1 MMP13 STUB1 BAX YES1 ESR1 SATB2 CDK4 WWTR1 PPARGC1A PPARGC1B BMP2 CDKN1A AKT2 PSMD8 AKT3 PSMD9 PSMD6 ESRRA SRC PSMD7 PSMD4 PSMD5 PSMD2 UCMA PSMD3 AKT1 PSMD1 PSMA5 BGLAP PSMA6 PSMA3 PSMA4 ZNF521 PSMA1 CBFB PSMA2 RUNX1 PSME3 PSME4 PSME1 PSME2 UBA52 PSMD10 PSMB11 PSMD12 COL1A1 PSMD11 PSMD14 IHH PSMD13 PSMA7 PSMB10 PSMA8 AR PSMB6 SOX9 PSMB7 TWIST2 PSMB4 YAP1 PSMB5 PSMB2 CCNB1 UBB ITGA5 PSMB3 SMAD6 UBC CDK1 PSMB1 PSMF1 RPS27A RB1 SHFM1 PSMB8 PSMB9 SKP2 MAF MAPK1 PSMC5 PSMC6 MAPK3 PSMC3 PSMC4 PSMC1 NR3C1 PSMC2 STAT1 HES1 DLX5 DLX6 GSK3B HEY1 HDAC3 HEY2 HDAC4 SP7 SMAD4 SMURF1 ABL1 HDAC6 NKX3-2 HAND2 PPM1D SMAD1 SKP1 RBX1 DOWNREGULATION OF ERBB4 SIGNALING%REACTOME%R-HSA-1253288.3 Downregulation of ERBB4 signaling UBC ITCH RPS27A UBA52 WWP1 NEDD4 SRC UBB SIGNALING BY ERBB2 TMD JMD MUTANTS%REACTOME DATABASE ID RELEASE 72%9665686 Signaling by ERBB2 TMD JMD mutants HRAS NRG1 NRG2 BTC NRG3 NRG4 NRAS HBEGF EREG EGF SHC1 EGFR PLCG1 SOS1 ERBB2IP HSP90AA1 CDC37 ERBB2 MITOPHAGY%REACTOME%R-HSA-5205647.4 Mitophagy MFN1 VDAC1 MFN2 TOMM70A TOMM7 TOMM5 TOMM6 UBA52 ATG12 TOMM20 TOMM22 CSNK2A1 ATG5 CSNK2A2 PARK2 ULK1 MTERF3 UBB CSNK2B MAP1LC3B UBC MAP1LC3A FUNDC1 RPS27A SQSTM1 TOMM40 PINK1 WNT MEDIATED ACTIVATION OF DVL%REACTOME DATABASE ID RELEASE 72%201688 WNT mediated activation of DVL CSNK2A2 DVL2 DVL1 PIP5K1B DVL3 CSNK2B CSNK1E CSNK2A1 GENE EXPRESSION (TRANSCRIPTION)%REACTOME DATABASE ID RELEASE 72%74160 Gene expression (Transcription) CUL1 MEN1 GLI3 GLI2 CPSF4 CPSF7 CPSF1 CSTF3 CPSF3 CSTF2 CPSF2 CSTF2T WDR33 NUDT21 FIP1L1 PABPN1 CLP1 PCF11 PAPOLA CSTF1 SYMPK ITCH ZNF350 BMI1 RNF2 TRIM28 CTSV CBX8 PHC2 CTSL PHC1 RING1 CTSK CBX4 CBX2 PCGF2 PHC3 FOXO1 CTDP1 NCBP1 NCBP2 SUPT4H1 SUPT5H GTF2F1 GTF2F2 POLR2A POLR2B POLR2C FOXO3 POLR2D POLR2G NELFB NELFA NELFCD POLR2I POLR2J NELFE PHAX PPARGC1A SNRPD3 PPARGC1B SNRPG SNRPE SNRPF SNRPB KIT ESR2 OPRK1 IHH KRAS SOX2 AR SOX9 RORA SSB NFIX NFIA NFIB NFIC RSPO3 RB1 WDR61 MYC LEO1 CDKN2B SKP2 MAX FKBP5 CDC7 TCF7 CDC73 EGFR LEF1 CEBPB TCF7L1 E2F5 NOP2 E2F6 HSPD1 ZFHX3 TGFB1 SMARCB1 RXRG SMAD4 SMURF1 HDAC10 RUNX3 EPC1 SMARCC1 SMARCC2 VENTX AFF4 CTR9 MLLT1 RTF1 VEGFA MLLT3 SUPT6H SETD1B IWS1 EAF1 SETD1A EAF2 BLM PAF1 SMARCA2 PCNA SMARCA4 CBX6 RPA1 RPA2 WRN RPA3 DNA2 ASH2L PRMT6 CCNC PBRM1 ACTL6B RELA TNFRSF18 YEATS4 TFAP2B CCND1 ARID2 KMT2E KMT2D KMT2A KMT2C KMT2B TCF7L2 ESR1 KCTD6 NFKB1 KLF4 CDK4 NOTCH2 NOTCH3 KDM5B NOTCH4 ZNF287 DPY30 ZNF17 ZNF18 WDR5 ZNF285 ZNF19 ZNF282 ZNF10 ZNF12 ZNF14 RXRB ZNF28 RXRA PRR5 ARID1A ZNF274 ARID1B ZNF273 ZNF20 ZNF23 SMARCD1 ZNF25 ZNF26 SMARCD2 ZNF268 ZNF267 HDAC8 ZNF266 RBBP5 ZNF264 SMARCE1 ZNF263 ZNF34 ZNF30 AKT2 ZNF257 AKT3 ZNF256 MYB ZNF496 MLST8 PGR ZNF254 GATA3 ZNF253 ZNF493 POU2F1 ZNF492 ZNF250 AXIN1 UCMA CITED1 ZNF490 PRKCB ZNF43 PDPK1 ZNF45 ZNF41 ZNF248 ZNF486 ZNF485 L3MBTL2 ZNF484 UXT ZNF483 YAF2 ZNF480 PCGF6 ZNF479 CBX5 ZNF235 MGA ZNF234 RYBP ZNF233 WWOX ZNF230 TFAP2D ZNF471 TFAP2E ZNF470 CCND3 MAPKAP1 CITED4 HTT CCND2 ZNF227 CDK6 ZNF468 ZNF226 ZNF225 ZNF224 ZNF223 ZNF222 ZNF461 ZNF460 RICTOR ATAD2 ZNF77 ZNF79 ZNF70 ZNF71 ZNF74 ZNF699 ZNF215 ZNF214 VDR ZNF697 ZNF213 CAV1 ZNF454 ZNF696 MTOR ZNF212 ZNF211 ZNF692 ZNF691 LSM10 ZNF208 LSM11 ZNF205 ZNF689 CTNNB1 ZNF446 ZNF688 ZNF445 ZNF202 ZNF443 ZNF442 ZNF200 ZNF684 ZNF441 ZNF440 ZNF682 ZNF681 ZNF680 ZFP69B MAF ZNF439 ZNF679 ZNF436 ZNF678 ZNF473 ZNF677 ZNF676 ZNF433 ZNF675 ZNF432 PVALB ZNF431 ZNF430 ZNF671 ZNF670 DLX5 DLX6 MOBP INS ZKSCAN7 ZNF429 ZKSCAN8 ZKSCAN3 ZNF669 FAS ZNF426 TNFRSF10B ZNF668 FASLG RAN ZNF425 ZKSCAN5 TNFRSF10A ZNF667 ZKSCAN4 ITGA4 ZNF665 ZNF664 ZKSCAN1 ZNF662 ZNF660 ZNF419 ZNF418 ZNF417 ZNF416 ZNF658 ZNF415 SP7 ZNF655 ZNF649 DGCR8 NKX3-2 ZNF641 HAND2 PPM1D ZNF627 ZNF626 ZNF625 ZNF624 MED1 ZNF621 ZNF620 ZNF860 ZNF619 ZNF616 ZNF615 MED8 ZNF614 ZNF613 ZNF611 MED4 ZNF610 MED6 ZNF729 MED7 ZNF727 ZNF726 ZNF721 ZNF720 ZFP1 ZFP2 ZNF716 BCL2L11 ZNF713 ZNF711 ZNF710 KCTD15 ZNF324B ZNF709 ZNF708 ZNF707 ZNF706 ZNF704 ZNF703 ZNF701 HIVEP3 ZNF700 ITGBL1 ZFP14 ZNF585B ZNF585A ZFP28 PRDM7 MSX2 ZNF99 ZNF92 GPRIN1 RBM14 ZNF804B ZNF175 ZSCAN32 FOXO6 ZNF169 FOXO4 ZNF705G ZNF705D NR4A1 ZNF160 ZNF705A ZSCAN25 ZNF157 ZNF398 ZNF155 ZNF154 ZNF394 ZNF383 ZNF141 ZNF382 ZNF140 ZNF37A ZNF138 ZNF136 ZNF135 ZNF133 ZNF124 ZIK1 BRD2 ZNF724P ZNF599 ZNF114 GPS2 ZNF597 ZNF596 ZNF112 ZNF347 ZNF589 ZNF587 ZNF586 ZIM2 ZNF343 ZIM3 ZNF101 ZNF584 ZNF100 ZNF583 YES1 ZNF582 IL6 ZNF33B ZNF33A ZNF337 ZNF577 ZNF334 ZNF333 ZNF331 ZNF573 ZNF571 ZNF570 ZFP30 ZNF569 ZNF568 ZNF567 ZNF324 ZNF566 ZNF565 SMAD7 ZFP37 ZNF564 ZNF563 MYL9 ZNF562 ZNF320 ZNF561 ZNF560 ZNF317 ZNF559 FKBP6 ZNF558 ZNF557 ZNF799 ZNF556 ZNF555 ZNF554 ZNF311 CRH ZNF552 ZNF551 ZNF793 ZNF550 DDIT3 ZNF792 ZNF791 ZNF790 KRBA1 KRBOX4 ZNF549 ZNF548 ZNF547 ZNF304 ZNF546 ZNF786 ZNF302 ZNF544 ZNF785 ESRRA ZNF543 ZNF300 ZNF782 ZNF540 ZFP69 CDK8 ZNF778 ZNF777 ZNF776 ZNF775 ZNF774 ZNF773 ZNF530 ZNF772 ZNF771 BGLAP ZNF770 TXNIP ZNF529 ZNF528 ZNF764 ZNF521 ZNF75D ZFP90 ZNF75A ZNF519 ZNF517 ZNF514 ZNF510 ZNF750 ZNF749 ZNF506 ZNF747 SMARCD3 ZNF746 ZNF500 ZNF740 ZNF738 ZNF737 ZNF736 ZNF735 ZNF732 ZNF730 ZNF607 ZNF606 ZNF605 ZNF600 ZNF839 HKR1 TWIST2 ZNF2 ZNF3 ZNF354A ZNF354C ZNF354B KCTD1 SMAD6 ZNF197 ZNF195 ZNF286A ZNF189 ZNF184 ZNF180 NOTCH1 MAML2 MAML1 HNF4G RBPJ THRB HES1 NR2C1 NR4A2 NR5A1 SNW1 MAML3 MAMLD1 THBS1 RARG RARA RARB TBL1X ITGAL RORC TBL1XR1 LGALS3 CSF1R TWIST1 RBFOX1 SLC2A3 MDC1 CCNK TP53RK MT-CO1 EHMT1 STUB1 NOC2L GLS TP53AIP1 KAT5 CHEK2 CHEK1 PIP4K2A PIP4K2B PIP4K2C TP63 DAXX PRKAB2 HUS1 PRKAB1 OPRM1 RRAGA COX7A2L SCO1 RRAGC SCO2 RRAGB DDIT4 RRAGD MT-CO2 MT-CO3 TP53 RHNO1 L3MBTL1 MEAF6 TXN PRDX2 NUAK1 BRIP1 PCBP4 PRDX1 TP53BP2 SFN ATRIP BANP BARD1 PLK3 POMC JUN PRELID1 SURF1 CREBBP CR1 CRADD GADD45A PLK2 TPX2 MOV10 AGO3 AGO4 AGO1 AGO2 RAD17 ATM CDK12 CDK13 TP73 ATR CDKN1A BTG2 COX7B CDKN1B ELL SETD8 SETD9 PHF20 PRKAG1 CHM PRKAG2 BRCA1 COX7C PRKAG3 BBC3 IL3 TAF7L RPTOR ING5 ING2 AIFM2 CASP10 TNKS1BP1 COX8A PRMT5 BRD1 RMI2 CNOT6L PRMT1 RMI1 ITGA2B TOP3A DDB2 RAD51D TCEB3CL2 COX5B COX5A PLAGL1 PERP TCEB3 PMS2 NR2E1 TCEB2 TCEB1 COL1A1 TCEB3CL TAF9B BID BRD7 TIGAR NPM1 CDKN2A MRE11A SPI1 COX6C CLDN5 MLH1 HIPK1 ZFPM1 GATA2 POU4F1 GATA1 LRPPRC NFE2 POU4F2 NFATC2 HIPK2 CTLA4 TTC5 CENPJ TAL1 YAP1 CCNG1 SERPINB13 TCEA1 PCGF5 LAMTOR2 RAD1 CSF2 LAMTOR1 LMO1 LAMTOR4 LMO2 FOXP3 LAMTOR3 SOCS4 LAMTOR5 AUTS2 STEAP3 CCNT2 IL2 CCNT1 NR4A3 TACO1 TCF3 PRDM1 LDB1 IL2RA COX6A1 STK11 SESN3 SESN2 NBN BNIP3L G6PD SUPT16H USP7 IGFBP3 USP2 TSC2 TSC1 CDC25C STAT1 COX6B1 MSH2 CCNE2 FANCD2 CCNE1 KAT6A MAPKAPK5 COX16 COX18 AK6 NDRG1 SMYD2 COX11 PMAIP1 COX14 SLC38A9 BCL2L14 MAP2K6 ZNF420 FANCI SLMO1 BRPF1 BRPF3 TNFRSF10C FANCC CNOT10 TNFRSF10D CNOT4 PPM1A CDK9 CNOT6 CNOT7 RGCC TP53I3 BCL6 CNOT11 CNOT1 RHEB CNOT2 CNOT3 JMY CDK2 MDM2 TAF4B CYCS PIN1 MDM4 CNOT8 RAD9B COX20 RAD9A YWHAE DYRK2 PPP1R13B COX4I1 PTEN TRIAP1 PIDD1 YWHAQ CASP6 PPP1R13L EXO1 CASP1 CASP2 TCEB3C TOPBP1 TCEB3B YWHAG ZNF385A YWHAH RFC5 GPX2 RFC3 RFC4 APAF1 RFC2 PPP2R5C RABGGTB RABGGTA RBL2 CCNA2 CCNA1 TFDP1 RBL1 TFDP2 RRM2B BIRC5 TMEM219 TMEM55B PRKAA1 RNF34 PRKAA2 CSNK2A1 GLS2 TAF9 TAF1L CSNK2A2 NLRC4 AURKB AURKA TP53INP1 E2F1 RBBP8 E2F4 RFFL E2F7 E2F8 CSNK2B TAF15 TAF12 TAF13 NDUFA4 TAF10 TXNRD1 MMP13 TAF11 ARID3A SSRP1 PML TNRC6C PLD6 RAD50 CARM1 RQCD1 BAX TAF7 TAF6 SPP1 TAF5 TAF4 TAF3 TAF2 TNRC6A TNRC6B TAF1 FZR1 TGFA BMP2 MTERF1 TFB2M GPAM POLRMT SIRT3 TFAM SOD2 CAMK4 ANAPC15 ANAPC16 ANAPC7 UBE2C UBE2E1 UBE2D1 ANAPC10 SOCS3 ANAPC11 CCNB1 GP1BA CDC23 CDC26 CDC27 CDC16 CDK1 ANAPC4 ANAPC5 ANAPC1 ANAPC2 PF4 RRN3 HDAC3 IPO8 GTF2B GTF2A1 GTF2A2 RNMT GTF2E1 GTF2E2 RNGTT GPI NUP107 NUP188 PPP2R1B PPP2R1A NUP62 PRKACA GRIN2A NDC1 INTS1 NUP214 INTS3 SEC13 INTS2 INTS5 G6PC INTS4 NUP133 INTS7 NUP210 INTS6 INTS9 INTS8 GRIN2B INTS12 INTS10 ICE1 NUP93 ICE2 NUP50 SSU72 NABP2 NABP1 NUP54 TAF8 ELL2 ELL3 ZC3H8 SERPINE1 RPRD2 NPPA SKIL RPAP2 TGIF1 ASUN TGIF2 VWA9 USP9X CPSF3L ATP1B4 RPRD1B SKI RPRD1A TRIM33 POU2F2 POM121 NUP205 AAAS NUP160 PPP2CA MED16 PPP2CB MED15 NUP85 TPR MED17 MED12 NUP88 NUP43 PCK1 RAE1 MED14 MED13 RANBP2 MED10 NUP155 TDRKH DICER1 MOV10L1 TARBP2 SATB2 NUP153 GATA4 BCDIN3D GCK PIWIL2 PIWIL1 PIWIL4 MED27 TSNAX NKX2-5 MED26 DDX4 WWTR1 MYBL1 DROSHA NUP35 MED23 HENMT1 NUPL2 MAEL TDRD12 MED25 NUP37 TSN MED24 XPO5 ASZ1 PRKRA MED20 TDRD9 TDRD6 TDRD1 GAD1 PPARG GAD2 PPARA PPARD SUMO1 BLK ELF1 ELF2 CBFB PAX5 RUNX1 TBX5 ATF2 CHD4 EP300 JUNB MEF2C MET MED30 TCF12 FOS MED31 CREB1 SGK1 SP1 MAPK1 EIF4A3 MAPK3 CASC3 MAGOH THOC1 THOC3 MAPK14 THOC2 THOC5 MAPK11 THOC7 CDC40 THOC6 CDK5 SRRM1 DDX39A DDX39B ZC3H11A SARNP SRSF2 SRSF3 CDK5R1 SRSF4 SRSF5 SRSF6 SRSF7 SLU7 SRSF9 MYBL2 FYTTD1 LUZP4 RBM8A HSP90AA1 POLDIP3 SRSF1 U2AF1 ERBB2 U2AF1L4 U2AF2 DHX38 SRSF11 CHTOP UPF3B MAGOHB RNPS1 SMAD1 CAMK2B GRIA2 CAMK2D CAMK2A APOE CAMK2G TEAD4 CTGF TEAD1 TEAD2 TEAD3 IFNG UBE2I SRRT RNF111 GTF3C1 GTF3C2 GTF3C3 GTF3C4 PTRF GTF3C5 CCNH EHMT2 GTF3C6 ARID4B SNAPC5 TTF1 RRM2 SNAPC1 RRP8 SNAPC2 SLBP ACTB SNAPC3 SAP130 SNAPC4 ZNF143 HIST1H2AE BRF2 HIST1H2AD HIST3H2BB BRF1 GTF3A HIST1H2AC BDP1 HIST1H2AB SAP30BP HIST1H2AJ CD3EAP SAP30 HIST2H3A HIST1H2BF PRKCQ HIST1H2BE HIST1H2BH HIST1H2BG HIST2H3D HIST1H2BB HIST1H2BA HIST2H3C GAMT HIST1H2BD TJP1 HIST1H2BC H2AFB1 OCLN ITGA5 DNMT1 HIST1H3J BAZ2A HIST1H3A HIST1H3F PARP1 HIST1H3G ACTL6A HIST1H3H HIST1H3I SUDS3 HIST1H3B HIST1H3C HIST1H3D HIST1H3E H3F3B HIST1H4K CBX3 UBE2D3 HIST1H4L H3F3A SMARCA5 H2BFS HIST1H4A CDK7 HIST1H4B CGA HIST1H4H HIST1H4I HIST1H4J HIST1H4C MNAT1 HIST1H4D HIST1H4E PHF19 NR1D1 EZH2 HIST1H4F HIST2H2AA3 YY1 GSK3B HIST2H2AA4 NEDD4L PHF1 SUV39H1 CHD3 HIST2H2AC DNMT3L ZNRD1 SIN3B H2AFJ SIN3A UBTF DNMT3B JARID2 TBP EED H2AFZ NCOR2 DNMT3A H2AFX TET2 NCOR1 TET1 CRCP H2AFV BAZ1B SIRT1 HIST2H2BE ABL1 KAT2B KAT2A AEBP2 POLR1A HIST4H4 POLR1B MTF2 TET3 POLR1C POLR1E BTG1 HIST1H2BN MSTN HIST1H2BM IGFBP1 HDAC2 SREBF1 HIST1H2BO TRIM63 NR1H2 POLR3GL HIST1H2BJ CAT HDAC1 UHRF1 FOXG1 POLR3A RETN POLR3B HIST1H2BI ATXN3 POLR3C HIST1H2BL POLR3D NPY HIST1H2BK DDX21 PLXNA4 POLR3E ABCA6 HIST2H4A POLR3F FBXO32 TAF1D POLR3G PINK1 HIST2H4B POLR3H CCNG2 MTA1 POLR3K AGRP RBBP4 TAF1B TAF1C TDG SAP30L TAF1A TWISTNB POLR2E POLR2F SAP18 POLR2H RBBP7 MTA2 SF3B1 MTA3 POLR2K POLR2L MBD3 SUZ12 MBD2 GTF2H1 DEK WWP1 GTF2H2 GTF2H3 GTF2H4 GATAD2B GTF2H5 GATAD2A MYBBP1A ERCC3 ERCC2 ERCC6 RAD51 LBR PTPN4 IRAK1 TFAP2A TFAP2C CITED2 PITX2 YWHAB PSMD8 PSMD9 PSMD6 SRC PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 AKT1 PSMD1 TRPC3 YWHAZ PTPN11 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 SMAD2 UBA52 SMAD3 PSMD10 PSMB11 BDNF PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 SMURF2 PSMB4 PSMB5 PSMB2 UBB PSMB3 THRA RORB UBC PSMB1 NR2C2 PSMF1 HNF4A NR2C2AP RPS27A ESRRB NR2F1 NR1D2 ESRRG NR0B2 SHFM1 NRBP1 NR2F6 PSMB8 PSMB9 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 NR3C1 NFYA NFYB NFYC PTPN1 HDAC11 HEY1 HEY2 HDAC4 HDAC5 DLL1 HDAC9 HDAC6 HDAC7 JAG1 LIFR SKP1 RBX1 SST FORMATION OF XYLULOSE-5-PHOSPHATE%REACTOME DATABASE ID RELEASE 72%5661270 Formation of xylulose-5-phosphate AKR1A1 DCXR CRYL1 XYLB SORD MYD88 CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 72%975871 MyD88 cascade initiated on plasma membrane CUL1 MAP2K1 MAPKAPK3 UBA52 MAPK8 PPP2R1B ATF1 PPP2R1A APP ATF2 NFKBIA IKBKG ELK1 RELA RPS6KA3 RPS6KA5 RPS6KA2 RPS6KA1 DUSP4 PPP2R5D MEF2A MEF2C DUSP3 FOS VRK3 UBB DUSP6 DUSP7 UBC CREB1 MAPKAPK2 RPS27A MAPK7 MAPK1 MAPK3 PPP2CA HMGB1 PPP2CB IKBKB NKIRAS1 NKIRAS2 MAPK14 MAP3K8 MAP2K3 CHUK MAPK11 MAP2K4 RIPK2 IRAK4 PELI1 UBE2N UBE2V1 PELI3 PELI2 NOD1 NFKB1 TLR10 NOD2 NFKB2 TLR5 AGER MAPK9 IRAK1 MAP2K6 S100A12 MAP2K7 MAP3K1 S100B MAPK10 TNIP2 JUN SAA1 MYD88 NFKBIB FBXW11 BTRC ECSIT SKP1 IRAK2 TRAF6 TAB3 TAB2 TAB1 MAP3K7 REGULATION OF GAP JUNCTION ACTIVITY%REACTOME%R-HSA-191650.2 Regulation of gap junction activity GJA1 TJP1 IRS ACTIVATION%REACTOME DATABASE ID RELEASE 72%74713 IRS activation IRS1 INS GRB10 IRS2 INSR DEFECTIVE ABCB6 CAUSES ISOLATED COLOBOMATOUS MICROPHTHALMIA 7 (MCOPCB7)%REACTOME DATABASE ID RELEASE 72%5683371 Defective ABCB6 causes isolated colobomatous microphthalmia 7 (MCOPCB7) ABCB6 DISEASES ASSOCIATED WITH GLYCOSYLATION PRECURSOR BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 72%5609975 Diseases associated with glycosylation precursor biosynthesis SRD5A3 MPI GALT NEU1 PGM1 DHDDS GFPT1 GNE NUS1 DPM1 PMM2 DPM2 DOLK GLB1 GALK1 DPM3 CTSA GALE CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6%REACTOME%R-HSA-69017.2 CDK-mediated phosphorylation and removal of Cdc6 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 CCNA2 CCNA1 UBA52 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 ANAPC15 ANAPC16 PSMB6 ANAPC7 PSMB7 UBE2C UBE2E1 PSMB4 UBE2D1 ANAPC10 PSMB5 ANAPC11 PSMB2 UBB CDC23 PSMB3 CDC26 CDC27 UBC CDC16 PSMB1 ANAPC4 PSMF1 ANAPC5 ANAPC1 RPS27A ANAPC2 SHFM1 PSMB8 PSMB9 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 FZR1 CCNE2 CDC6 CCNE1 CDK2 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 ACTIVATION AND OLIGOMERIZATION OF BAK PROTEIN%REACTOME%R-HSA-111452.2 Activation and oligomerization of BAK protein BAK1 BID ERYTHROPOIETIN ACTIVATES PHOSPHOLIPASE C GAMMA (PLCG)%REACTOME DATABASE ID RELEASE 72%9027277 Erythropoietin activates Phospholipase C gamma (PLCG) EPO JAK2 LYN PLCG1 PLCG2 IRS2 EPOR SIGNALING BY RHO GTPASES%REACTOME%R-HSA-194315.4 Signaling by Rho GTPases CDH1 IQGAP2 IQGAP3 MEN1 YWHAG YWHAH PPP2R5C ERCC6L ZWILCH BUB1B CASC5 CDC20 KNTC1 DYNC1LI1 BIRC5 DYNC1LI2 CLIP1 ZW10 MAD1L1 CDCA8 PMF1 SKA1 AURKB SKA2 DSN1 RCC2 NDC80 ZWINT KIF18A SGOL2 SGOL1 NUF2 SPDL1 NDEL1 NUDC MYH14 MYH10 DYNLL2 MKL1 KIF2A INCENP KIF2C KIF2B ITGB3BP MIS12 CENPA NSL1 CENPC BUB3 BUB1 DYNC1I1 CLASP2 CENPT CENPU CENPE CENPF CENPH CENPI TAOK1 CENPK CENPL CENPM IQGAP1 CENPN B9D2 CENPO CENPP CENPQ SPC24 MAD2L1 SPC25 A2M AR PLK1 EVL SOS1 PIK3C3 ARHGEF18 PRKCZ RHOA CFTR CTTN NUP107 PPP2R1B DAAM1 PPP2R1A PFN1 SEC13 NUP133 PIK3R4 PPP2R5D KDM1A KIF5B KIF5A DIAPH1 NUP160 PPP2CA PPP2CB NUP85 NUP43 RANBP2 WASL RTKN NCOA2 RHPN1 TAX1BP3 NUP37 RHPN2 ROPN1 CYFIP2 CYFIP1 NCKAP1 NCF1 NCF2 NCF4 BRK1 KDM4C PFN2 KLK3 KLK2 SCAI RAC1 NOX3 NCK1 KIF14 VAV3 PRKCB CIT PKN3 PDPK1 KTN1 PKN2 CYBB GOPC CYBA PKN1 VAV1 CFL1 VAV2 DIAPH3 NF2 PPP1R12B PPP1R14A LIMK2 LIMK1 FMNL3 ROCK1 FMNL1 ROCK2 FMNL2 PRC1 PIK3R2 CDC42 PAK1 CTNNA1 NCKAP1L WASF1 PAK3 WASF2 PAK2 WASF3 BAIAP2 PTK2 ABI2 ABI1 CTNNB1 SRF MAPK1 MAPK3 MAPK14 MAPK11 AHCTF1 RANGAP1 TRIO ITSN1 PREX1 ARHGEF40 ITGB1 OBSCN NGEF ARHGEF26 KALRN ABR ECT2 ARHGEF33 ARHGEF35 ARHGEF37 ARHGEF39 ARHGEF38 NET1 RASGRF2 ARHGEF10L DLG4 AKAP13 MCF2L ARHGEF11 ARHGEF10 ARHGEF12 PLEKHG2 ARHGEF15 ARHGEF17 PLEKHG5 ARHGEF16 ARHGEF19 ARHGEF9 ARHGEF3 ARHGEF4 ARHGEF1 ARHGEF2 SOS2 ARHGEF5 FGD1 FGD2 FGD3 GNA13 FGD4 MCF2 MYL12B MYLK MYH11 PPP1CB MYL6 MYL9 PPP1R12A MYH9 DYNLL1 CKAP5 MAPRE1 PAFAH1B1 DYNC1I2 WIPF1 WIPF2 CLASP1 WIPF3 DYNC1H1 NOX1 ARPC1B NDE1 ARPC1A WAS NOXO1 MYO9B ACTG1 ACTB NCKIPSD DVL1 HIST1H2AE HIST1H2AD HIST3H2BB DVL3 ARPC4 HIST1H2AC ARPC5 HIST1H2AB ARPC2 ARPC3 HIST1H2AJ NOXA1 ACTR3 HIST2H3A ACTR2 HIST1H2BF HIST1H2BE HIST1H2BH HIST1H2BG HIST2H3D HIST1H2BB HIST1H2BA HIST2H3C HIST1H2BD HIST1H2BC H2AFB1 HIST1H3J HIST1H3A HIST1H3F HIST1H3G HIST1H3H HIST1H3I HIST1H3B HIST1H3C HIST1H3D HIST1H3E H3F3B HIST1H4K HIST1H4L H3F3A H2BFS HIST1H4A HIST1H4B HIST1H4H HIST1H4I HIST1H4J APITD1 HIST1H4C INPP5B HIST1H4D HIST1H4E HIST1H4F HIST2H2AA3 HIST2H2AA4 HIST2H2AC H2AFJ H2AFZ H2AFX H2AFV HIST2H2BE ABL1 HIST4H4 HIST1H2BN HIST1H2BM HIST1H2BO S100A9 HIST1H2BJ S100A8 HIST1H2BI HIST1H2BL HIST1H2BK HIST2H4A HIST2H4B PPP1CC OCRL FAM13B FAM13A ARHGDIG ARHGAP39 ARHGAP36 SYDE2 SFN ARHGAP44 SYDE1 ARHGAP42 OPHN1 ARHGAP40 ARHGDIB RALBP1 STARD8 HMHA1 BCR DEPDC1B ARHGAP19 ARHGAP18 ARHGAP17 ARHGAP15 RHOBTB1 RHOBTB2 ARHGAP12 ARHGAP22 ARHGAP21 RHOT2 ARHGAP20 RHOT1 RACGAP1 SRGAP3 SRGAP1 STARD13 CDKN1B ARHGAP29 ARHGAP28 ARHGAP27 YWHAB ARHGAP26 ARHGAP25 ARHGAP24 ARHGAP23 ARHGAP33 XPO1 ARHGAP32 ARHGAP31 ARHGAP30 ARHGAP11A TIAM2 ARHGAP9 ARHGAP11B PPP2R5E ARHGAP8 GDI1 GDI2 ARHGAP1 ARHGAP5 PPP2R5B PRKCD ARHGAP6 LIN7B PPP2R5A PRKCA ARHGAP4 TAGAP YWHAZ RAC2 RAC3 ARHGEF7 RHOG ARAP2 ARAP3 RHOH RHOF RHOC GMIP RHOD RHOB ARHGAP10 DEPDC7 RHOJ RHOU TIAM1 RHOV RHOQ CHN2 CHN1 RPS27 MYO9A DLC1 TRIP10 DVL2 ARHGDIA FLNA ARHGAP35 CDC25C ARAP1 KLC1 KLC4 KLC3 KLC2 PIN1 YWHAE BTK ARHGEF6 YWHAQ DEFECTIVE CYP21A2 CAUSES ADRENAL HYPERPLASIA 3 (AH3)%REACTOME DATABASE ID RELEASE 72%5579021 Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3) CYP21A2 REGULATION OF TP53 ACTIVITY THROUGH ASSOCIATION WITH CO-FACTORS%REACTOME%R-HSA-6804759.1 Regulation of TP53 Activity through Association with Co-factors AKT1 POU4F1 POU4F2 ZNF385A TP53 TP73 PHF20 AKT2 TP53BP2 AKT3 PPP1R13B BANP TP63 PPP1R13L TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING%REACTOME%R-HSA-975110.1 TRAF6 mediated IRF7 activation in TLR7 8 or 9 signaling IRAK1 TRAF6 IRAK4 UBE2N TLR9 IRF7 TLR8 TLR7 MYD88 UBE2V1 DEFECTIVE ABCC6 CAUSES PSEUDOXANTHOMA ELASTICUM (PXE)%REACTOME DATABASE ID RELEASE 72%5690338 Defective ABCC6 causes pseudoxanthoma elasticum (PXE) ABCC6 GAP JUNCTION TRAFFICKING%REACTOME%R-HSA-190828.1 Gap junction trafficking DNM1 MYO6 GJD2 GJA1 GJB2 GJB1 GJC1 GJA10 GJA3 GJA5 GJA4 GJA9 GJA8 GJC2 CLTC DNM2 GJB4 CLTB GJB3 CLTA GJB6 GJB5 GJB7 CLTCL1 GJD4 GJD3 AP2M1 DAB2 SMALL INTERFERING RNA (SIRNA) BIOGENESIS%REACTOME DATABASE ID RELEASE 72%426486 Small interfering RNA (siRNA) biogenesis DICER1 PRKRA TARBP2 AGO3 AGO4 AGO1 TSNAX AGO2 TSN ESTROGEN BIOSYNTHESIS%REACTOME%R-HSA-193144.4 Estrogen biosynthesis HSD17B11 AKR1B15 HSD17B1 HSD17B2 CYP19A1 HSD17B14 CAM PATHWAY%REACTOME%R-HSA-111997.1 CaM pathway CAMK2D CAMK2A PRKAR2B PRKAR2A PRKCD PRKCA CAMK2G PRKCG NBEA CAMK4 CAMKK1 ADCY4 CAMKK2 ADCY3 PRKACG ADCY2 ADCY1 PRKACA ADCY8 PRKACB ADCY7 ADCY6 PDE1B ADCY5 PDE1C PDE1A ADRBK1 PRKX KPNA2 CREB1 ADCY9 PRKAR1B PRKAR1A CAMK2B MYD88 DEFICIENCY (TLR5)%REACTOME DATABASE ID RELEASE 72%5602680 MyD88 deficiency (TLR5) TLR5 MYD88 SIGNALING BY ERBB2 ECD MUTANTS%REACTOME%R-HSA-9665348.1 Signaling by ERBB2 ECD mutants HRAS NRAS EGF SHC1 GAB1 PIK3R1 EGFR PIK3CA PLCG1 SOS1 ERBB2IP HSP90AA1 CDC37 ERBB2 P38MAPK EVENTS%REACTOME%R-HSA-171007.3 p38MAPK events RALA HRAS MAPKAPK2 MAPK14 RALGDS MAPK11 MAPKAPK3 RALB MAPK12 MAPK13 NRAS ACETYLCHOLINE REGULATES INSULIN SECRETION%REACTOME%R-HSA-399997.1 Acetylcholine regulates insulin secretion PLCB2 CHRM3 MARCKS GNA14 PRKCA GNA15 PLCB3 GNA11 GNAQ PLCB1 FBXW7 MUTANTS AND NOTCH1 IN CANCER%REACTOME%R-HSA-2644605.1 FBXW7 Mutants and NOTCH1 in Cancer CUL1 SKP1 RBX1 NOTCH1 DEFECTIVE CYP2R1 CAUSES RICKETS VITAMIN D-DEPENDENT 1B (VDDR1B)%REACTOME%R-HSA-5579027.2 Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B) CYP2R1 VPU MEDIATED DEGRADATION OF CD4%REACTOME%R-HSA-180534.1 Vpu mediated degradation of CD4 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 UBA52 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 CD4 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 UBB PSMB3 UBC PSMB1 PSMF1 RPS27A SHFM1 PSMB8 PSMB9 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 BTRC SKP1 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 METABOLISM OF VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 72%196854 Metabolism of vitamins and cofactors VKORC1L1 SDC4 SDC2 SDC3 MMAB APOM PPCS PNPO SLC19A3 APOE APOB SLC19A1 SLC19A2 SLC25A32 MTHFR MTHFS BST1 PDXK PLB1 MTHFD1 MTHFD2 SDC1 PDSS2 SHMT2 PDSS1 SHMT1 HLCS RDH11 THTPA RFK NMRK2 NMRK1 ABCD4 PRKG2 SLC2A1 LRAT SLC2A3 HSPG2 APOA2 PDZD11 DHFR NAPRT APOA1 SLC5A6 APOA4 RBP4 FASN AOX1 SLC5A8 RBP2 RBP1 CYP8B1 ABCC1 PTGIS TTR CTRC NMNAT3 RETSAT BCO2 BCO1 NMNAT2 ENPP2 ENPP1 NMNAT1 ENPP3 APOC3 GSTO2 CD38 GSTO1 PC UBIAD1 APOC2 PANK4 NNMT VKORC1 CYB5R3 PANK2 PANK3 MTRR GPIHBP1 PANK1 GPC1 GPC3 GPC2 GPC5 GPC4 GPC6 AASDHPPT FLAD1 GCH1 QPRT AKR1C1 AKR1C3 AKR1C4 AGRN MTHFD2L GIF ALDH1L1 AKT1 ALDH1L2 CARKD DHFRL1 AMN NUDT12 ACACB ACACA COASY PTGS2 APOA1BP VNN1 VNN2 PRSS1 SLC52A2 NOS3 SLC52A3 CD320 SLC52A1 NAMPT SLC22A13 PRSS3 PARP6 FOLR2 PARP4 SLC46A1 PARP9 PARP8 MTR NADSYN1 NADK GPHN MCCC2 MCCC1 LMBRD1 MMAA PTS MUT TTPA NT5E PCCA MTHFD1L PCCB SPR ACP5 TCN2 TCN1 NADK2 MOCS2 MOCS3 SLC25A16 HSP90AA1 PARP16 PARP14 SLC25A19 PARP10 AKR1B10 GCHFR PNLIP LRP1 PPCDC LPL IDH1 SLC23A2 COQ9 SLC23A1 COQ7 CUBN COQ6 LRP2 COQ5 COQ3 LDLR LRP8 COQ2 RNLS TPK1 CTRB2 CTRB1 MOCOS LRP10 LRP12 MMACHC BTD CLPS MMADHC CYB5A METABOLISM OF AMINE-DERIVED HORMONES%REACTOME DATABASE ID RELEASE 72%209776 Metabolism of amine-derived hormones TH CGA AANAT DUOX2 ASMT DIO1 DIO2 DIO3 TPH2 DDC TPH1 PNMT SLC5A5 IYD TPO TSHB DBH DUOX1 TAT-MEDIATED ELONGATION OF THE HIV-1 TRANSCRIPT%REACTOME DATABASE ID RELEASE 72%167246 Tat-mediated elongation of the HIV-1 transcript GTF2F1 GTF2F2 CDK7 POLR2A POLR2B TCEB3C POLR2C POLR2D TCEB3B POLR2G POLR2E NELFB MNAT1 POLR2F NELFA NELFCD POLR2H POLR2I POLR2J NELFE POLR2K TCEB3CL2 CCNH POLR2L TCEB3 GTF2H1 TCEB2 GTF2H2 TCEB1 GTF2H3 TCEB3CL GTF2H4 GTF2H5 ERCC3 ERCC2 CDK9 TCEA1 ELL CCNT1 SSRP1 CTDP1 NCBP1 SUPT16H NCBP2 SUPT4H1 SUPT5H LATENT INFECTION - OTHER RESPONSES OF MTB TO PHAGOCYTOSIS%REACTOME DATABASE ID RELEASE 72%1222499 Latent infection - Other responses of Mtb to phagocytosis LTF DISEASES OF THE NEURONAL SYSTEM%REACTOME DATABASE ID RELEASE 72%9675143 Diseases of the neuronal system OPN1LW ABCA4 OPN1MW OPN1MW2 TTR RDH12 NAPEPLD LRAT OPN1SW RDH5 RBP4 RBP1 STRA6 RLBP1 DISEASES OF CELLULAR SENESCENCE%REACTOME%R-HSA-9630747.2 Diseases of Cellular Senescence CDK6 CDK4 CDKN2A MYOCLONIC EPILEPSY OF LAFORA%REACTOME DATABASE ID RELEASE 72%3785653 Myoclonic epilepsy of Lafora UBC PPP1R3C EPM2A RPS27A UBA52 GYS1 UBB GYG1 NHLRC1 NERVOUS SYSTEM DEVELOPMENT%REACTOME DATABASE ID RELEASE 72%9675108 Nervous system development RPS4X PRKAR2A RPS3A NUMB PMP22 CSNK2A1 CSNK2A2 SH3GL2 CSNK2B MYH14 MYH10 NCBP1 NCBP2 CLASP2 UNC5A UNC5B HRAS RASA1 NRAS RPLP1 RPLP0 RPLP2 RPS27L ABL2 CAP2 RPL22L1 IRS2 VASP ENAH EVL NTN4 HSP90AB1 PIK3CD SHC1 GAB1 PIK3R1 EGFR PIK3CA PLCG1 SOS1 ALCAM DPYSL4 DPYSL5 DPYSL2 DPYSL3 UNC5C UNC5D AGAP2 FLRT3 RDX PPP3CB LYPLA2 DSCAML1 ZSWIM8 FARP2 MSI1 RHOA PLXNC1 SEMA6A SEMA6D SEMA7A PLXNA2 PLXNA1 PLXNA3 DAB1 CLTCL1 LHX3 LHX2 PLXNB3 PLXNB1 LHX4 LHX9 SEMA3A SEMA3E ABLIM1 ABLIM2 ABLIM3 SEMA4A SEMA4D SMARCA4 RPS6KA4 EPHA5 EPHA4 EPHA7 EPHA6 DNM1 EPHA8 ANK2 DNM3 HFE2 RPL23A ANK3 SHTN1 EZR EPHA3 EPHA2 EPHA10 RPS6KA6 RRAS NRP2 RGMB RGMA RELN PAK7 KCNQ2 PAK6 KCNQ3 PAK4 CD72 DSCAM PRKACG PFN1 DOK4 DOK5 PRKACA DOK6 FES PRKACB ARHGEF28 EFNA5 EFNA4 EFNA1 EFNA3 EFNA2 USP33 EFNB2 RND1 EFNB1 GAP43 EFNB3 CRMP1 EPHB2 PDLIM7 GRIN2B EPHB1 PIK3R3 EPHB4 EPHB3 PIP5K1C SCN11A SCN9A SCN1B ISL1 SCN1A RPL27A CACNB1 SCN10A CACNB4 GIT1 SCN8A WASL NEO1 CACNA1S SCN3B SCN3A WWTR1 SCN2A SCN2B GRIN1 GPC1 CLTC ITGB3 CLTB CLTA AP2A1 SCN5A PIK3CB AP2B1 AP2A2 AP2S1 TREM2 AP2M1 TRPC1 PFN2 NCK2 ITGAV TYROBP RAC1 SCN4A CXCL12 NCK1 SCN4B AGRN VAV3 NCAM1 CFL1 VAV2 SCN7A LIMK2 DOCK1 LIMK1 ROCK1 ROCK2 CXCR4 DLG3 PIK3R2 CDC42 PAK1 NAB1 NAB2 FYN PAK3 RPS6KA3 PAK2 RPS6KA5 RPS6KA2 RPS6KA1 PTK2 MET MAPK12 MAPK13 DNM2 CREB1 MAPK7 MAPK1 EIF4A3 MAPK3 CASC3 EGR2 MAGOH MAPK14 MAPK11 CDK5 RAP1GAP CDK5R1 RPL26L1 RPL4 RBM8A RPL5 HSP90AA1 RPL30 RPL3 ERBB2 RPL32 RPL31 RPL34 RPL8 RPL9 RPL6 RPL7 UPF3B MAGOHB RPL36 TRIO RNPS1 ITSN1 RPL35 RPL38 RPL37 RPL39 NCAN RPL21 RPL23 MAG ITGB1 RPL22 GRB7 NGEF LAMC1 DOK2 PSEN2 PSEN1 KALRN RPL24 RPL27 ITGA2 APH1A RPL26 NCSTN RPL29 SDC2 LAMA2 APH1B AKAP5 LAMA1 RPL28 RANBP9 LAMB1 RPL41 DLG1 DLG4 RPL3L PSENEN ARHGEF11 ARHGEF12 SOS2 MSN SREBF2 CNTNAP1 DCX NRCAM RPL10 RPL12 RPL11 RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 LYN MYL12A MYL12B YES1 MYH11 ITGA1 MYL6 TEAD1 MYL9 RPS9 RPS7 RPS8 RPS5 CACNA1D RPS6 CACNA1C RPSA CACNB2 CACNB3 MYH9 DCC PITPNA NTN1 CLASP1 RPL7A ARPC1B ARPC1A MYO9B ACTG1 RPL37A ACTB SPTAN1 ARPC4 ARPC5 ARPC2 RPL36A ARPC3 ACTR3 RPL35A ACTR2 PRKCQ ROBO2 MYO10 NELL2 SLIT1 SLIT3 SLIT2 ROBO1 L1CAM ITGA5 ITGA9 RPS4Y2 RPS4Y1 RET GFRA3 SEMA5A SHC3 CUL2 DAG1 NRTN GFRA1 GSK3B SPTB GFRA2 GFRA4 SPTBN4 SPTBN5 CACNA1H CACNA1G SPTA1 RPL39L CACNA1I SPTBN1 SPTBN2 PRNP PSPN GDNF PTPRA ARTN CNTN2 ABL1 RPS15A HOXA2 HDAC2 TRPC5 TRPC4 PLXNA4 TLN1 PTPRC RPL10L RPL10A MAP2K1 MAP2K2 SCD5 FAU NFASC MAPK8 RPL13A CAP1 MMP2 PLXND1 CNTN1 CYP51A1 ARHGAP39 ST8SIA4 RPS15 SDCBP RPS14 RPS17 ST8SIA2 RPS16 RPS19 RPL18A SRGAP3 RPL36AL SRGAP1 RPS18 RPS11 RPS10 RPS13 PSMD8 PSMD9 RPS12 PSMD6 SH3KBP1 SRC PSMD7 MMP9 PSMD4 PSMD5 PSMD2 PSMD3 TRPC7 PSMD1 TRPC6 ADAM10 TRPC3 PRKCA PTPN11 PSMA5 UTRN PSMA6 ARHGEF7 PSMA3 PSMA4 MBP PSMA1 ITGA2B EPHA1 PSMA2 PSME3 RHOC PSME4 PSME1 PSME2 RHOB ADGRV1 PABPC1 UBA52 RPS26 TCEB2 PSMD10 TIAM1 TCEB1 PSMB11 RPS25 PSMD12 RPS28 GSPT2 MPZ PSMD11 GSPT1 RPS27 POU3F1 PSMD14 UPF3A POU3F2 COL4A2 PSMD13 RPS29 COL4A1 ADGRG6 PSMA7 COL6A2 RPS20 PSMB10 PSMA8 RPS21 COL4A4 RPS24 UPF2 RPS23 PSMB6 COL6A1 ETF1 COL4A3 PSMB7 HMGCR PSMB4 COL9A1 YAP1 PSMB5 PSMB2 COL6A3 COL4A5 UBB PSMB3 GRB10 COL9A3 COL6A6 COL9A2 UBC SOX10 PSMB1 GAB2 COL6A5 PSMF1 RPS27A LDB1 HSPA8 SHFM1 SIAH2 SIAH1 PSMB8 PSMB9 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 ARHGAP35 EIF4G1 FRS2 DOK1 NRP1 CNTN6 CHL1 ITGA10 ANK1 VLDLR KIF4B KIF4A PRX DRP2 RBX1 RHO GTPASES ACTIVATE CIT%REACTOME%R-HSA-5625900.2 RHO GTPases activate CIT PPP1R12A MYL12B MYH9 PPP1R12B RHOA MYH11 RHOC PRC1 CDKN1B RHOB DLG4 MYH14 MYH10 PPP1CB MYL6 MYL9 RAC1 KIF14 CIT MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF SATURATED FATTY ACIDS%REACTOME%R-HSA-77286.2 mitochondrial fatty acid beta-oxidation of saturated fatty acids HADH ACADS HADHB ACADVL HADHA ECHS1 ACSM3 MECR ACSM6 ACADL ACADM ELASTIC FIBRE FORMATION%REACTOME DATABASE ID RELEASE 72%1566948 Elastic fibre formation ITGB5 LOXL3 LOXL4 MFAP5 LOXL1 LOXL2 MFAP4 EFEMP2 MFAP1 EFEMP1 MFAP3 MFAP2 LOX FBN2 FBN3 LTBP4 LTBP2 FBLN1 LTBP3 LTBP1 TGFB1 FBLN2 FBLN5 GDF5 ELN TGFB2 TGFB3 BMP7 ITGA5 VTN BMP4 BMP2 ITGB3 ITGB1 FBN1 BMP10 ITGB8 ITGB6 ITGAV FURIN ITGA8 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 72%381676 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion KCNG2 GNG11 KCNS3 GNG13 PRKAR2B AKAP5 PRKAR2A GNB2 GNB1 GNB4 GNB3 GNAS GNB5 IQGAP1 GNGT1 ITPR1 ITPR2 GNGT2 ITPR3 PRKACG PRKACA ADCY8 PRKACB ADCY6 ADCY5 RAP1A GNG3 GNG2 GNG5 GNG4 RAPGEF3 GNG7 GNG8 RAPGEF4 GNG10 KCNB1 GLP1R GCG PRKAR1B KCNC2 PRKAR1A GNG12 BUDDING%REACTOME%R-HSA-168302.3 Budding P75NTR NEGATIVELY REGULATES CELL CYCLE VIA SC1%REACTOME%R-HSA-193670.1 p75NTR negatively regulates cell cycle via SC1 HDAC3 HDAC2 HDAC1 PRDM4 NGFR NGF PI3K AKT SIGNALING%REACTOME%R-HSA-1257604.8 PI3K AKT Signaling PPP2R5C FOXO6 CSNK2A1 FOXO4 NR4A1 RPS6KB2 CSNK2A2 BMI1 RNF2 CSNK2B CBX8 XIAP PHC2 PHC1 RING1 CBX4 CBX2 PML TNRC6C PHC3 FOXO1 CD86 LCK CD80 CD28 TNRC6A TNRC6B FOXO3 BTC EPGN TGFA AREG HBEGF EREG IER3 PDGFRB KIT PHLPP2 PHLPP1 PDGFB ESR2 STRN PIK3AP1 TRIM27 IRS1 IRS2 THEM4 TRAT1 EZH2 PIK3CD GSK3B EGF GAB1 PIK3R1 CHD3 EGFR PIK3CA EED HDAC3 HDAC2 HDAC1 MTA1 CBX6 RBBP4 RBBP7 MTA2 MTA3 MECOM MBD3 SUZ12 FGF6 FGF9 PPP2R1B PPP2R1A FGF20 GATAD2B FGF1 FGF2 GATAD2A FGF23 FGF3 FGF22 FGF10 FGF4 PPP2R5D IL1RL1 PIK3R3 PIP5K1A PIP5K1B KDM1A IL33 PIP5K1C PREX2 USP13 TNKS TNKS2 WWP2 RNF146 STUB1 FRK OTUD3 PIP4K2A PIP4K2B PIP4K2C PPP2CA PPP2CB RRAGA RRAGC GSK3A CHUK RRAGB BAD CASP9 RRAGD MKRN1 IRAK4 TP53 ESR1 IRAK1 JUN MYD88 MOV10 AGO3 AGO4 AGO1 AGO2 PPARG PRR5 CDKN1A CD19 CDKN1B PIK3CB AKT2 PSMD8 AKT3 PSMD9 MLST8 PSMD6 SRC PSMD7 PSMD4 RAC1 PSMD5 PSMD2 RPTOR PPP2R5E PSMD3 PDPK1 AKT1 PSMD1 VAV1 PPP2R5B PPP2R5A PTPN11 RAC2 PSMA5 TRIB3 PSMA6 RHOG PSMA3 PSMA4 SALL4 PSMA1 PSMA2 PSME3 MAPKAP1 PSME4 PSME1 PSME2 UBA52 ATN1 PIK3R2 NR2E1 MAF1 PSMD10 SNAI1 PSMB11 SNAI2 PSMD12 ATF2 RICTOR PSMD11 PSMD14 FYN PSMD13 CHD4 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 MTOR HGF PSMB4 MET PSMB5 PSMB2 LAMTOR2 KLB UBB PSMB3 LAMTOR1 LAMTOR4 INSR LAMTOR3 LAMTOR5 UBC PSMB1 PSMF1 FGF19 CREB1 FGFR4 RPS27A SHFM1 PSMB8 PSMB9 PSMC5 MAPK1 PSMC6 PSMC3 USP7 MAPK3 EGR1 PSMC4 PSMC1 PSMC2 TSC2 NRG1 NRG2 FRS2 REST NEDD4 FGF16 NRG3 FGF7 NRG4 FGF18 INS PDGFRA SLC38A9 ERBB2 AKT1S1 HDAC5 RHEB HDAC7 MDM2 TRAF6 PTEN GLUCAGON SIGNALING IN METABOLIC REGULATION%REACTOME%R-HSA-163359.2 Glucagon signaling in metabolic regulation GNG11 GNG13 PRKAR2B PRKAR2A GNB2 GNB1 CYSLTR2 GNB4 GNB3 GNAS ADCY4 ADCY3 PRKACG ADCY2 ADCY1 PRKACA ADCY8 PRKACB ADCY7 ADCY6 ADCY5 GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 GNG10 ADCY9 GCG PRKAR1B PRKAR1A GNG12 CHONDROITIN SULFATE BIOSYNTHESIS%REACTOME%R-HSA-2022870.2 Chondroitin sulfate biosynthesis CHST11 CHST12 CSGALNACT1 CHST15 CHST13 CSGALNACT2 BCAN VCAN NCAN CHST3 CHPF2 BGN CHST7 CHPF CSPG5 CSPG4 DCN CHSY1 CHSY3 ACTIVATION OF C3 AND C5%REACTOME DATABASE ID RELEASE 72%174577 Activation of C3 and C5 C3 CFB C4B_2 C4B C4A C2 C5 MITOCHONDRIAL TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 72%163316 Mitochondrial transcription termination MTERF1 SLC TRANSPORTER DISORDERS%REACTOME%R-HSA-5619102.5 SLC transporter disorders SLC7A7 SLC1A3 SLC7A9 SLC24A4 SLC22A5 SLC20A2 SLC3A2 SLC3A1 SLC39A4 NUP107 NUP188 SLC26A2 HK1 RHAG SLC24A5 NUP62 SLC16A1 NDC1 SLC2A9 NUP214 SEC13 NUP133 NUP210 NUP93 NUP50 SLC2A1 SLC2A2 NUP54 SLC2A10 SLC6A2 SLC6A20 SLC6A5 SLC40A1 HEPH SLC5A1 SLC5A2 SLC35A2 SLC35A1 SLC6A3 POM121 SLC35A3 SLC35C1 NUP205 SLCO1B1 SLCO1B3 SLC12A3 SLC33A1 SLC11A2 SLC24A1 AAAS NUP160 SLC12A1 SLC12A6 SLCO2A1 NUP85 TPR AVP NUP88 NUP43 SLC29A3 RAE1 RANBP2 SLC27A4 GCKR NUP155 NUP153 GCK CP SLC4A1 SLC5A5 AVPR2 SLC4A4 NUP35 AVPR1B NUPL2 AVPR1A SLC17A8 SLC6A19 SLC5A7 NUP37 SLC34A3 SLC6A18 SLC34A2 SLC34A1 SLC17A5 SLC6A14 SLC9A6 SLC9A9 BSG SLC22A12 SLC26A4 SLC26A3 SLC22A18 SLC1A1 SLC36A2 G-PROTEIN ACTIVATION%REACTOME DATABASE ID RELEASE 72%202040 G-protein activation GNG11 OPRM1 GNG13 GNAO1 GNB2 GNB1 GNB4 GNB3 GNB5 GNGT1 GNGT2 POMC GNAT2 PDYN GNAI3 GNAT3 GNAI1 GNAI2 GNG3 GNAT1 GNG2 GNG5 GNG4 GNG7 GNG8 GNAZ GNG10 GNG12 MRNA EDITING: A TO I CONVERSION%REACTOME DATABASE ID RELEASE 72%75064 mRNA Editing: A to I Conversion ADAR ADARB1 NOTCH-HLH TRANSCRIPTION PATHWAY%REACTOME%R-HSA-350054.3 Notch-HLH transcription pathway MAML2 MAML1 TBL1X RBPJ SNW1 MAML3 MAMLD1 TBL1XR1 NOTCH2 NOTCH3 NOTCH4 CREBBP NCOR2 HDAC11 HDAC3 NCOR1 HDAC4 HDAC5 HDAC10 HDAC9 HDAC6 KAT2B HDAC7 KAT2A HDAC8 HDAC2 HDAC1 NOTCH1 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE%REACTOME DATABASE ID RELEASE 72%1660514 Synthesis of PIPs at the Golgi membrane PI4K2B PIK3C2G PIK3R4 PIK3C2A FIG4 ARF3 INPP5E PI4K2A ARF1 VAC14 TPTE2 OCRL SACM1L PI4KB PIKFYVE PIK3C3 TPTE PP2A-MEDIATED DEPHOSPHORYLATION OF KEY METABOLIC FACTORS%REACTOME DATABASE ID RELEASE 72%163767 PP2A-mediated dephosphorylation of key metabolic factors PPP2CA PPP2CB MLXIPL PPP2R5D PPP2R1B PPP2R1A PFKFB1 PLATELET AGGREGATION (PLUG FORMATION)%REACTOME DATABASE ID RELEASE 72%76009 Platelet Aggregation (Plug Formation) PDPK1 AKT1 CRK ITGA2B SHC1 ADRA2C PTPN1 ADRA2A RASGRP2 SYK APBB1IP SOS1 RASGRP1 RAP1B FGB FGA FN1 VWF GP1BB PTK2 MPL RAP1A THPO FGG GP1BA F2 RAPGEF3 GP5 BCAR1 ITGB3 RAPGEF4 GP9 SRC CSK TLN1 MPS IIIC - SANFILIPPO SYNDROME C%REACTOME%R-HSA-2206291.2 MPS IIIC - Sanfilippo syndrome C HGSNAT NEGATIVE REGULATION OF FGFR3 SIGNALING%REACTOME%R-HSA-5654732.1 Negative regulation of FGFR3 signaling PPP2CA PPP2CB BRAF FRS2 PTPN11 SPRY2 FGF16 FGF18 UBB UBC CBL RPS27A UBA52 FGF9 PPP2R1A FGF20 FGF1 FGF2 FGF23 MKNK1 MAPK1 MAPK3 FGF4 RAS SIGNALING DOWNSTREAM OF NF1 LOSS-OF-FUNCTION VARIANTS%REACTOME%R-HSA-6802953.1 RAS signaling downstream of NF1 loss-of-function variants SPRED2 SPRED1 HRAS NRAS NF1 SPRED3 ANCHORING OF THE BASAL BODY TO THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 72%5620912 Anchoring of the basal body to the plasma membrane HAUS7 CEP70 PRKAR2B CEP72 CEP192 PCNT CEP76 YWHAG CLASP1 CEP78 PLK4 DYNC1H1 ODF2 CEP152 MKS1 NDE1 NEDD1 FGFR1OP CEP41 OFD1 PPP2R1A PRKACA PLK1 CENPJ CDK1 RAB3IP TUBA4A RAB11A CEP97 FBF1 TTBK2 B9D2 CEP83 CEP89 CEP57 C2CD3 CETN2 TUBA1A CEP164 TCTN3 CCP110 TCTN2 TCTN1 ACTR1A CC2D2A PCM1 HSP90AA1 KIF24 CNTRL CEP250 TMEM67 NEK2 NINL CEP290 RAB8A B9D1 CDK5RAP2 CEP135 NPHP1 NPHP4 MARK4 TUBB CEP131 AHI1 HAUS4 HAUS3 HAUS6 CSNK1D HAUS5 IQCB1 CSNK1E TUBG1 DYNLL1 SEPT2 CKAP5 HAUS2 TMEM216 HAUS1 AKAP9 CEP63 SCLT1 MAPRE1 CEP162 YWHAE SFI1 TUBB4B RPGRIP1L PAFAH1B1 TUBB4A SDCCAG8 DYNC1I2 DCTN2 SSNA1 DCTN3 HAUS8 THYROXINE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 72%209968 Thyroxine biosynthesis CGA DUOX2 SLC5A5 IYD TPO DIO1 TSHB DUOX1 DIO2 DIO3 DEFECTIVE AHCY CAUSES HYPERMETHIONINEMIA WITH S-ADENOSYLHOMOCYSTEINE HYDROLASE DEFICIENCY (HMAHCHD)%REACTOME%R-HSA-5578997.1 Defective AHCY causes Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD) AHCY XENOBIOTICS%REACTOME DATABASE ID RELEASE 72%211981 Xenobiotics CYP3A4 CYP3A5 CYP3A7 CYP3A43 ARNT2 CYP2W1 AHR ARNT CYP2A7 CYP1A2 CYP2A6 CYP1A1 CYP2F1 CYP2B6 CYP2S1 CYP2C19 CYP2C18 AHRR CYP2A13 CYP2J2 CYP2C9 CYP2C8 CYP2D6 CYP3A7-CYP3A51P CYP2E1 GPCR LIGAND BINDING%REACTOME DATABASE ID RELEASE 72%500792 GPCR ligand binding CXCL6 GRM7 CXCL9 GRM6 CXCL3 GPER1 CXCL13 GRM8 CXCL2 QRFPR CX3CL1 SSTR1 PTCH1 CXCL5 SSTR2 CXCL16 SSTR4 CCRL2 SSTR5 HTR6 CCR9 CNR2 HTR7 CCR8 GNAS CNR1 HTR1E CCR7 TAS1R2 HTR1F CCR6 TAS1R1 HTR1D CCR4 TAS1R3 HTR2B CCR3 CCK HTR1A CCR2 OPN1SW HTR1B XCL2 ACKR1 RXFP4 HTR2C XCL1 GRPR HTR2A CX3CR1 HTR4 RXFP3 CCL13 PROK2 CCL11 HTR5A PROK1 CCL3L1 CMKLR1 CCL3L3 TRHR CXCR5 GALR3 CXCR6 GALR2 CCL7 APP GALR1 CCL5 WNT10B CXCR3 WNT10A CCL4 FZD9 CCL3 GPR183 CCL2 PNOC CCL1 GPR132 CCL19 OPN1LW CCL17 CCL16 OPN1MW CCR10 RGR CCL25 GPR4 CCR1 CCL22 GPR143 HCAR2 SSTR3 XCR1 HCAR3 CCL21 HCAR1 CCL20 CHRM1 CXCL10 CXCL11 CHRM4 ACKR4 ACKR3 CHRM5 ACKR2 CCL28 MCHR1 CCL27 MTNR1A MTNR1B TRH INSL5 OXTR RRH AVP EDNRA EDNRB UTS2R GPR37L1 UTS2B PTGFR NLN PPY NTSR1 NTSR2 NMB NMBR NMS NMU QRFP BRS3 CCKAR FFAR3 WNT3A FZD4 FFAR2 FZD6 EDN1 EDN2 FZD8 EDN3 AVPR1B AVPR1A CCKBR NPB PTGER1 PTGER3 NPW KISS1R F2RL1 F2RL2 F2RL3 PMCH NPY2R GHSR NPY1R APLNR SUCNR1 NTS OPN4 OPN3 C3 PTCH2 OPN5 PYY NMUR2 NMUR1 TAS2R7 TAS2R9 TAS2R8 WNT2B MLNR HEBP1 BDKRB2 BDKRB1 TAS2R1 TAS2R3 TAS2R5 TAS2R4 NPY5R WNT16 CORT NPY4R OPRL1 S1PR3 S1PR2 S1PR5 S1PR4 OPRK1 SHH KISS1 DHH KNG1 IHH HRH1 HRH3 HRH4 F2R F2 WNT9A WNT8A WNT8B PF4 GNG10 GNG12 GNG11 GNG13 GNB2 GNB1 GNB4 WNT1 GNB3 WNT3 WNT4 GNB5 GNGT1 GNGT2 GNG3 CHRM2 GNG2 GNG5 GNG4 GNG7 GNG8 AGTR1 CXCL8 WNT11 UCN FFAR4 GPR17 LTB4R2 LTB4R GRP P2RY1 GABBR2 GABBR1 FZD2 FZD5 WNT5A CXCL12 PTAFR CCR5 CXCR4 GRM1 GRM5 TBXA2R VIPR1 VIPR2 SCT RXFP1 RXFP2 CYSLTR1 PTGDR LHCGR TAAR8 TAAR9 TAAR6 TAAR5 TAAR2 TAAR1 ADCYAP1 IAPP ADCYAP1R1 CALCA CALCRL CALCB GIPR ADRB1 ADRB2 CRHR1 GHRHR GCG MC2R CALCR HRH2 DRD1 DRD5 MC1R RLN2 RLN3 ANXA1 AGT ADM PTH1R MC4R CHRM3 INSL3 GPR39 FSHB AVPR2 GLP2R GPBAR1 PTH2R GIP MC3R ADORA2A ADRB3 ADORA2B FSHR CRH NPSR1 PTGER4 RAMP2 RAMP3 PTH PTGER2 PTH2 PTHLH NPS PSAP GPHA2 P2RY11 SCTR TSHR GHRH ADM2 MC5R VIP RAMP1 GPHB5 C3AR1 ADRA2C ADRA2A FPR1 FPR2 CGA FFAR1 NPY TACR2 TACR3 TAC3 TACR1 CYSLTR2 TAC1 DRD2 DRD3 DRD4 PPBP OPRD1 TSHB RHO OPRM1 S1PR1 CXCR1 CXCR2 POMC SAA1 C5AR2 C5AR1 C5 CXCL1 CD55 ADGRE5 ADGRE3 P2RY12 PTGIR P2RY13 P2RY10 P2RY14 LPAR4 P2RY6 P2RY4 LHB LPAR6 ADORA3 P2RY2 ADORA1 FZD10 CRHBP ADRA1D PDYN ADRA1B FZD1 ADRA1A AGTR2 FZD3 FPR3 FZD7 NPBWR1 NPBWR2 HCRT GPR18 GPRC6A UCN3 UCN2 GPR37 GPR35 WNT9B GPR31 PROKR1 PROKR2 WNT7B GPR55 WNT7A GPR68 GPR65 UTS2 ECE1 PRLHR HCRTR2 HCRTR1 APLN OPN1MW2 NPFFR2 NPFFR1 TAS2R20 OXER1 TAS2R10 NPFF TAS2R13 TAS2R14 TAS2R16 TAS2R19 KEL TAS2R40 TAS2R41 TAS2R42 TAS2R43 TAS2R46 LPAR1 LPAR2 LPAR3 PENK TAS2R30 TAS2R31 TAS2R38 TAS2R39 LPAR5 GNRH2 GNRH1 TAS2R60 PTGDR2 MLN GNRHR OXGR1 TAS2R50 GAL PRLH XK CASR MCHR2 WNT6 WNT2 OXT GLP1R GRM3 ADGRE1 SMO ADGRE2 GRM2 SST GRM4 DEFECTIVE BASE EXCISION REPAIR ASSOCIATED WITH NEIL1%REACTOME%R-HSA-9616334.2 Defective Base Excision Repair Associated with NEIL1 NEIL1 GLYCOGEN STORAGE DISEASES%REACTOME DATABASE ID RELEASE 72%3229121 Glycogen storage diseases G6PC PPP1R3C GBE1 GYS2 GYS1 GAA UBB UBC EPM2A RPS27A UBA52 G6PC3 GYG2 GYG1 NHLRC1 MTORC1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 72%166208 mTORC1-mediated signalling RPS6 RPS6KB1 RRAGA AKT1S1 EIF4E EIF4G1 RRAGC MTOR RRAGB RHEB RRAGD LAMTOR2 LAMTOR1 LAMTOR4 LAMTOR3 LAMTOR5 SLC38A9 YWHAB MLST8 EEF2K EIF4EBP1 EIF4B RPTOR DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY%REACTOME%R-HSA-3371598.1 Defective BTD causes biotidinase deficiency BTD IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%R-HSA-975144.1 IRAK1 recruits IKK complex upon TLR7 8 or 9 stimulation PELI2 IKBKB IRAK1 CHUK TRAF6 UBE2N PELI1 IKBKG UBE2V1 PELI3 POLB-DEPENDENT LONG PATCH BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 72%110362 POLB-Dependent Long Patch Base Excision Repair PARP1 LIG1 PARP2 ADPRHL2 APEX1 POLB FEN1 PARG SNRNP ASSEMBLY%REACTOME DATABASE ID RELEASE 72%191859 snRNP Assembly PRMT5 NUP107 TGS1 NUP188 NUP62 NDC1 NUP214 SEC13 NUP133 NUP210 NUP93 NUP50 NUP54 POM121 NUP205 NCBP1 NCBP2 AAAS NUP160 NUP85 TPR NUP88 NUP43 RAE1 RANBP2 NUP155 NUP153 GEMIN2 NUP35 PHAX NUPL2 SNRPD2 SNRPD1 SNRPD3 NUP37 CLNS1A SNRPG GEMIN4 GEMIN5 SNRPE GEMIN6 GEMIN7 SNRPF GEMIN8 SNRPB DDX20 SMN2 SMN1 SNUPN WDR77 CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 72%446728 Cell junction organization CDH1 COL17A1 LAMA3 LAMB3 PVR PXN CLDN2 CDH9 CLDN1 CTNNA1 CDH8 CDH7 CDH6 CLDN22 CLDN20 CDH3 CLDN23 DST CLDN11 CLDN5 CLDN6 JUP ILK CLDN10 CLDN4 CLDN3 CLDN15 PLEC CLDN14 CLDN9 CLDN8 CDH10 CLDN12 CLDN7 CDH11 CTNNB1 CLDN19 CDH12 CLDN18 CDH13 ANG VASP CLDN17 CLDN16 CDH17 CDH18 FBLIM1 PARD6G PARD6B CDH24 FLNC CADM3 CADM2 CADM1 MPP5 INADL PVRL4 TESK1 PVRL3 FERMT2 PARVB PVRL1 LIMS2 FLNA RSU1 CRB3 LIMS1 ITGB4 CDH4 CDH2 ACTN1 ITGA6 CDH15 CD151 PVRL2 F11R PRKCI PARD6A PARD3 CTNND1 ITGB1 LAMC2 CDH5 ARHGEF6 SDK1 SDK2 PLATELET ACTIVATION, SIGNALING AND AGGREGATION%REACTOME%R-HSA-76002.3 Platelet activation, signaling and aggregation ECM1 OLA1 CTSW SERPINA4 TMSB4X TIMP3 ANXA5 TOR4A LY6G6F PLCG2 LHFPL2 PCYOX1L FAM49B FAM3C TMX3 RARRES2 PRKCG SCCPDH LGALS3BP WDR1 PLEK PHACTR2 SRGN MMRN1 ITIH4 GNA14 RASGRP2 ITIH3 GNA15 C6orf25 CLEC3B APP PDPN RASGRP1 CDC37L1 CLEC1B PCDH7 GP6 GNA11 SPARC ARRB1 DGKG DGKE DGKD DGKB DGKA GNA13 ABHD12 DGKZ DGKQ STX4 DGKK DGKI DGKH ABHD6 DAGLA LCK DAGLB LYN PPIA SYK PLA2G4A F2RL2 F2RL3 MGLL TGFB2 TGFB3 GNAQ CFD PSAP ALB PLG PDGFB IGF2 APOOL GAS6 ADRA2C ADRA2A GNA12 PROS1 F13A1 KNG1 A2M PRKCQ FGB FGA GNAT3 VWF GP1BB F2R FGG GP1BA F2 GP5 F5 LEFTY2 GP9 F8 LAT TUBA4A SERPING1 GNG10 PF4 A1BG GNG12 GNG11 GNG13 GNB2 GNB1 GNB4 GNB3 SERPINA3 ACTN1 SERPINA1 GNB5 PIK3CG EGF GNGT1 SHC1 PIK3R1 GNGT2 AHSG PIK3CA SOS1 TTN THBS1 TGFB1 GNAI3 GNAI1 GNAI2 PRKCZ LAMP2 GNG3 RHOA GNG2 GNG5 GNG4 GNG7 GNG8 VEGFA TLN1 ACTN4 RAF1 SOD1 TIMP1 ACTN2 PFN1 SPP2 STXBP2 PIK3R3 PIK3R6 PIK3R5 PPBP ORM1 SERPINE1 ALDOA ORM2 SELP APOA1 CD109 QSOX1 CAP1 FCER1G RAB27B CALU CD63 P2RY1 IGF1 TF CD36 CLU MPL THPO RAPGEF3 ITGB3 RAPGEF4 PIK3CB FIGF PRKCE VEGFB VEGFC P2RY12 SRC RAC1 LCP2 CSK VAV3 PRKCB AAMP TRPC7 PDPK1 AKT1 TRPC6 TRPC3 VAV1 PRKCD VAV2 CFL1 PRKCA YWHAZ PTPN11 RAC2 RHOG CRK ITGA2B ARRB2 PTPN6 RHOB ITPR1 ITPR2 ITPR3 PIK3R2 CDC42 APBB1IP VCL FYN RAP1B FN1 PTK2 HGF STXBP3 RAP1A BCAR1 HSPA5 MAPK1 MAPK3 CYB5R1 FLNA MAPK14 ABCC4 PTPN1 BRPF3 TBXA2R APLP2 SCG3 PRKCH ISLR HABP4 CHID1 SERPINF2 GTPBP2 SYTL4 SEPP1 TAGLN2 NHLRC2 TEX264 CD9 ENDOD1 APOH VTI1B MANF MAGED2 HRG FERMT3 DEFECTIVE SLC24A1 CAUSES CONGENITAL STATIONARY NIGHT BLINDNESS 1D (CSNB1D)%REACTOME%R-HSA-5619077.1 Defective SLC24A1 causes congenital stationary night blindness 1D (CSNB1D) SLC24A1 RNA POLYMERASE I PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 72%73854 RNA Polymerase I Promoter Clearance RBBP4 TAF1B TAF1C TAF1A TWISTNB POLR2E POLR2F POLR2H RBBP7 MTA2 MTA3 POLR2K POLR2L MBD3 MBD2 GTF2H1 GTF2H2 GTF2H3 GTF2H4 GATAD2B GTF2H5 GATAD2A ERCC3 ERCC2 ERCC6 CCNH EHMT2 TTF1 HIST1H2AE HIST1H2AD HIST3H2BB HIST1H2AC HIST1H2AB HIST1H2AJ CHD4 CD3EAP HIST2H3A HIST1H2BF HIST1H2BE HIST1H2BH HIST1H2BG HIST2H3D HIST1H2BB HIST1H2BA HIST2H3C HIST1H2BD HIST1H2BC H2AFB1 HIST1H3J HIST1H3A HIST1H3F HIST1H3G HIST1H3H HIST1H3I HIST1H3B HIST1H3C HIST1H3D HIST1H3E H3F3B HIST1H4K CBX3 HIST1H4L RRN3 H3F3A MAPK3 H2BFS HIST1H4A CDK7 HIST1H4B HIST1H4H HIST1H4I HIST1H4J HIST1H4C MNAT1 HIST1H4D HIST1H4E HIST1H4F HIST2H2AA3 HIST2H2AA4 CHD3 HIST2H2AC ZNRD1 H2AFJ UBTF TBP H2AFZ H2AFX H2AFV HIST2H2BE KAT2B KAT2A POLR1A HIST4H4 POLR1B POLR1C POLR1E HIST1H2BN HIST1H2BM HDAC2 HIST1H2BO HIST1H2BJ HDAC1 HIST1H2BI HIST1H2BL HIST1H2BK HIST2H4A TAF1D HIST2H4B MTA1 ARACHIDONATE PRODUCTION FROM DAG%REACTOME DATABASE ID RELEASE 72%426048 Arachidonate production from DAG DAGLB ABHD12 MGLL ABHD6 DAGLA DEFECTIVE CYP26C1 CAUSES FOCAL FACIAL DERMAL DYSPLASIA 4 (FFDD4)%REACTOME%R-HSA-5579004.1 Defective CYP26C1 causes Focal facial dermal dysplasia 4 (FFDD4) CYP26C1 CELL-CELL COMMUNICATION%REACTOME%R-HSA-1500931.4 Cell-Cell communication CD2AP NPHS1 CDH1 LAMA3 LAMB3 PVR ACTN2 SIRPB1 SIRPG CADM3 CADM1 PVRL4 PVRL3 PVRL1 CD47 CDH4 CDH2 WASL IQGAP1 CDH15 CD151 SIRPA CTNND1 PIK3CB CDH5 NCK2 TYROBP NCK1 CASK COL17A1 PTPN11 PTPN6 PXN PIK3R2 CLDN2 CDH9 CLDN1 SPTAN1 CTNNA1 CDH8 PTK2B CDH7 CDH6 CLDN22 FYN CLDN20 CDH3 CLDN23 DST CLDN5 CLDN11 CLDN6 JUP ILK CLDN10 CLDN4 CLDN3 CLDN15 PLEC PTK2 CLDN14 CLDN9 CLDN8 CDH10 CLDN12 CLDN7 CDH11 CTNNB1 CLDN19 CDH12 CLDN18 CDH13 VASP ANG CLDN17 CLDN16 CDH17 CDH18 FBLIM1 PARD6G PARD6B CDH24 FLNC CADM2 FYB MPP5 SKAP2 INADL TESK1 FERMT2 PARVB LIMS2 RSU1 FLNA CRB3 LIMS1 ITGB4 ACTN1 ITGA6 PIK3R1 PIK3CA SPTBN1 PVRL2 ACTN3 F11R PRKCI PARD6A PARD3 ITGB1 LAMC2 ARHGEF6 SDK1 KIRREL3 SDK2 KIRREL KIRREL2 MAGI2 ACTN4 SIGNALING BY RECEPTOR TYROSINE KINASES%REACTOME DATABASE ID RELEASE 72%9006934 Signaling by Receptor Tyrosine Kinases SPARC ITCH SH3GL2 BAX NCBP1 SPP1 NCBP2 LCK GTF2F1 GTF2F2 POLR2A POLR2B POLR2C POLR2D POLR2G NELFB MAP2K5 POLR2I POLR2J SPRED2 SPRED1 HRAS RASA1 BTC EPGN TGFA AREG NRAS HBEGF EREG FURIN PCSK6 NGF PCSK5 PDGFRB KIT PLG PDGFB RNF41 STAT5A STAT5B IRS1 IRS2 THEM4 EGF SHC1 GAB1 TIAL1 PIK3R1 TIA1 CBL RBFOX2 EGFR PIK3CA ESRP2 PLCG1 SOS1 PIK3C3 FLRT3 IGF1R PRKCZ RHOA STAT3 VEGFA DNM1 DNM3 NRP2 JAK2 GABRG3 GABRG2 FGF6 FGF9 PTPRU ANOS1 SOCS6 PPP2R1B SH2B3 PPP2R1A FGF20 PRKACG FGF1 FER FGF2 TEC PRKACA FGF23 FES PRKACB FGF3 GRAP FGF22 FGF10 FGF4 PIK3R4 PPP2R5D GRIN2B PIK3R3 GABRB3 GABRB2 GABRB1 PTPRS FGFBP1 FGFBP2 FGFBP3 MEMO1 DIAPH1 PPP2CA PPP2CB CMA1 ESR1 IGF1 GABRQ GABRA1 PRR5 CYFIP2 CYFIP1 NCKAP1 AHCYL1 NCF1 NCF2 CLTC ITGB3 NCF4 CLTA CTNND1 BRK1 AP2A1 PIK3CB AP2B1 SHB AP2A2 AP2S1 CDH5 AKT2 AKT3 AP2M1 PGR MLST8 GRAP2 KDR NCK2 ITGAV RAC1 CXCL12 NCK1 VAV3 PRKCB PDPK1 SPHK1 CYBB CYBA VAV1 VAV2 MAPKAPK3 ELMO1 ELMO2 TRIB3 CRK DOCK1 WWOX SHC2 ROCK1 ROCK2 STAM MAPKAP1 SH2D2A PXN ITPR1 ITPR2 ITPR3 PIK3R2 CDC42 PAK1 ATF1 CTNNA1 SH3GL3 STAM2 PTK2B ATF2 RICTOR NCKAP1L NAB1 NAB2 FYN MKNK1 WASF1 CHD4 ELK1 NTRK3 PAK3 WASF2 RPS6KA3 PAK2 LYL1 WASF3 RPS6KA5 JUP RPS6KA2 RPS6KA1 NOS3 EP300 CAV1 JUNB GGA3 BAIAP2 DUSP4 RAB4B MTOR MEF2A PTK2 HGF MEF2C MET MAPK12 DUSP3 RAP1A CRKL MAPK13 TCF12 ARF6 ABI2 FOS AXL ABI1 VRK3 F3 CTNNB1 DUSP6 BCAR1 DNM2 DUSP7 ARC CREB1 VGF MAPKAPK2 SGK1 TRIB1 TPH1 RRAD SRF ASCL1 MAPK7 MAPK1 MEF2D MAPK3 EGR1 EGR2 JUND EGR3 EGR4 MAPK14 FOSL1 MAPK11 REST CDK5 ID2 ID1 ID4 FOSB ID3 INS CDK5R2 CDK5R1 ERBB2IP HSP90AA1 CDC37 ERBB2 ITGB1 LAMC3 DOCK7 GRB7 LAMC2 PTPRJ SPINT2 LAMC1 TNS4 TNS3 PSEN2 HGFAC PSEN1 USP8 ITGA3 ITGA2 APH1A SPINT1 NTF4 RAPGEF1 NCSTN LAMA5 LAMA2 APH1B LAMA1 LAMA4 HPN LAMA3 LAMB3 LAMB2 RANBP9 APOE LAMB1 RANBP10 MUC20 PTPN2 DLG4 PSENEN NTRK2 NTF3 RALA RALGDS DNAL4 FGFRL1 DOCK3 STMN1 PTPRO FLRT2 RALB FLRT1 HNRNPF KIDINS220 CILP RIT1 IRS4 ADCYAP1 RIT2 ADAP1 ADAM17 CSN2 MST1R MXD4 ADCYAP1R1 NTRK1 LYN HNRNPM YES1 PTBP1 HNRNPH1 ADORA2A SOCS1 GFAP HNRNPA1 IGF2 HGS PLAT THBS4 THBS3 PDGFD SHC3 THBS2 THBS1 NCOR1 GALNT3 STAT6 ATP6V0D1 MAP2K1 MAP2K2 BRAF POLR2E POLR2F POLR2H POLR2K POLR2L WWP1 RAB4A PTPN18 MATK TCIRG1 STUB1 ATP6V1E1 ATP6V1E2 ATP6V1G1 CHEK1 ATP6V0B ATP6V0E1 ATP6V1G2 ATP6AP1 ATP6V1B2 ATP6V0C ATP6V0D2 ATP6V1B1 ATP6V1A ATP6V0A2 TLR9 ATP6V1H FLT4 ATP6V0A4 ATP6V0E2 ATP6V1G3 ATP6V1D ATP6V1C1 ATP6V1F ATP6V0A1 ATP6V1C2 S100B FIGF YWHAB FLT1 HSPB1 PRKCE VEGFB VEGFC PGF SH3KBP1 SRC PTPRK MMP9 LRIG1 CSK EPS15 AAMP PAG1 AKT1 SH3GL1 ADAM10 EPS15L1 PTPN12 PRKCD EPN1 PRKCA ADAM12 PTPN11 SPRY2 SPRY1 ARHGEF7 PTPN3 PTPN6 UBA52 TIAM1 BDNF ESRP1 COL4A2 COL4A1 COL6A2 RAP1B COL4A4 COL6A1 COL4A3 COL9A1 YAP1 KLB COL6A3 FLT3 COL4A5 UBB PDE3B GRB10 COL9A3 INSR COL6A6 FLT3LG COL9A2 UBC GAB2 COL6A5 FGF19 FGFR4 RPS27A STAT1 NRG1 NRG2 FRS2 FRS3 NRP1 NRG3 NEDD4 FGF16 FGF7 NRG4 FGF18 PDGFRA PTPN1 PTK6 CUL5 TAB2 TLR3-MEDIATED TICAM1-DEPENDENT PROGRAMMED CELL DEATH%REACTOME%R-HSA-9013957.2 TLR3-mediated TICAM1-dependent programmed cell death RIPK1 FADD RIPK3 TICAM1 TLR3 CASP8 CLASS B 2 (SECRETIN FAMILY RECEPTORS)%REACTOME DATABASE ID RELEASE 72%373080 Class B 2 (Secretin family receptors) RAMP1 PTCH1 CYSLTR2 GNAS WNT16 VIPR1 VIPR2 SCT SHH WNT11 DHH WNT10B IHH WNT10A FZD9 FZD10 CRHBP UCN FZD1 FZD3 FZD7 ADCYAP1 UCN3 UCN2 IAPP ADCYAP1R1 CALCA WNT9B CALCRL CALCB GIPR WNT7B WNT9A WNT7A WNT8A WNT8B CRHR1 GNG10 GHRHR GCG CALCR GNG12 GNG11 GNG13 GNB2 GNB1 GNB4 WNT1 GNB3 WNT3 WNT4 GNB5 ADM PTH1R GNGT1 GNGT2 WNT3A FZD4 FZD6 GLP2R FZD8 PTH2R GIP CRH GNG3 RAMP2 GNG2 RAMP3 GNG5 FZD2 GNG4 FZD5 WNT5A PTH GNG7 GNG8 PTH2 PTHLH CD55 PTCH2 ADGRE5 ADGRE3 WNT6 WNT2 SCTR GLP1R ADGRE1 GHRH ADGRE2 SMO ADM2 WNT2B VIP FORMATION OF HIV-1 ELONGATION COMPLEX CONTAINING HIV-1 TAT%REACTOME%R-HSA-167200.3 Formation of HIV-1 elongation complex containing HIV-1 Tat GTF2F1 GTF2F2 CDK7 POLR2A POLR2B TCEB3C POLR2C POLR2D TCEB3B POLR2G POLR2E NELFB MNAT1 POLR2F NELFA NELFCD POLR2H POLR2I POLR2J NELFE POLR2K TCEB3CL2 CCNH POLR2L TCEB3 GTF2H1 TCEB2 GTF2H2 TCEB1 GTF2H3 TCEB3CL GTF2H4 GTF2H5 ERCC3 ERCC2 CDK9 TCEA1 ELL CCNT1 SSRP1 CTDP1 NCBP1 SUPT16H NCBP2 SUPT4H1 SUPT5H COPI-MEDIATED ANTEROGRADE TRANSPORT%REACTOME%R-HSA-6807878.1 COPI-mediated anterograde transport RAB1B DCTN4 ANK2 ARCN1 GORASP1 CAPZA3 ANK3 DYNC1H1 CAPZA1 CAPZA2 FOLR1 COPG2 BET1 NSF COPG1 ACTR10 SPTAN1 DYNC1LI1 DYNC1LI2 ARF4 NAPA DYNLL2 NAPB GOSR1 NAPG GBF1 DYNC1I1 GOLGA2 KDELR1 GOLGB1 ANK1 KDELR2 INS STX5 SPTB COPB2 COPA YKT6 TMED10 COG8 SPTBN4 COPB1 SPTBN5 COG7 COG6 COG5 SPTA1 COG4 ACTR1A COG3 SPTBN1 COG2 SPTBN2 COG1 DCTN1 BET1L GOSR2 COPE TMED2 CAPZB TMED3 USO1 TMED7 TMED9 COPZ2 DYNLL1 ARF3 ARF1 ARFGAP3 ARFGAP1 CD59 COPZ1 ARFGAP2 CD55 DYNC1I2 ARF5 DCTN2 KDELR3 DCTN6 DCTN3 TMEM115 RAB1A DCTN5 ACTIVATION OF PUMA AND TRANSLOCATION TO MITOCHONDRIA%REACTOME DATABASE ID RELEASE 72%139915 Activation of PUMA and translocation to mitochondria TFDP1 E2F1 TP53BP2 TFDP2 PPP1R13B TP53 TP63 TP73 BBC3 DISPLACEMENT OF DNA GLYCOSYLASE BY APEX1%REACTOME DATABASE ID RELEASE 72%110357 Displacement of DNA glycosylase by APEX1 MBD4 SMUG1 TDG NTHL1 APEX1 OGG1 MPG HEREDITARY FRUCTOSE INTOLERANCE%REACTOME DATABASE ID RELEASE 72%5657560 Hereditary fructose intolerance ALDOB PHOSPHORYLATION OF PROTEINS INVOLVED IN THE G2 M TRANSITION BY CYCLIN A:CDC2 COMPLEXES%REACTOME%R-HSA-170145.2 Phosphorylation of proteins involved in the G2 M transition by Cyclin A:Cdc2 complexes CDK1 CCNA2 CCNA1 DEFECTIVE MOGS CAUSES MOGS-CDG (CDG-2B)%REACTOME DATABASE ID RELEASE 72%4793954 Defective MOGS causes MOGS-CDG (CDG-2b) MOGS DEFECTIVE UGT1A4 CAUSES HYPERBILIRUBINEMIA%REACTOME DATABASE ID RELEASE 72%5579016 Defective UGT1A4 causes hyperbilirubinemia UGT1A4 HIV TRANSCRIPTION INITIATION%REACTOME%R-HSA-167161.2 HIV Transcription Initiation GTF2F1 TAF2 GTF2B GTF2F2 CDK7 GTF2A1 POLR2A GTF2A2 POLR2B TAF1 POLR2C GTF2E1 POLR2D GTF2E2 POLR2G POLR2E MNAT1 POLR2F POLR2H POLR2I POLR2J AK6 POLR2K CCNH POLR2L GTF2H1 GTF2H2 GTF2H3 GTF2H4 TAF9B GTF2H5 TBP ERCC3 ERCC2 TAF9 TAF1L TAF15 TAF12 TAF13 TAF4B TAF10 TAF11 TAF7 TAF6 TAF5 TAF7L TAF4 TAF3 DEFECTIVE MISMATCH REPAIR ASSOCIATED WITH MSH3%REACTOME DATABASE ID RELEASE 72%5632927 Defective Mismatch Repair Associated With MSH3 MSH2 MSH3 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS%REACTOME DATABASE ID RELEASE 72%264870 Caspase-mediated cleavage of cytoskeletal proteins VIM ADD1 CASP7 CASP3 MAPT PLEC SPTAN1 GSN DBNL CASP6 CASP8 GAS2 INVADOPODIA FORMATION%REACTOME%R-HSA-8941237.1 Invadopodia formation ADAM19 ADAM12 ADAM15 SH3PXD2A FCERI MEDIATED NF-KB ACTIVATION%REACTOME DATABASE ID RELEASE 72%2871837 FCERI mediated NF-kB activation PSMD3 PDPK1 CUL1 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 UBA52 PSMD10 PSMB11 RASGRP2 PSMD12 RASGRP1 PSMD11 PSMD14 NFKBIA IKBKG PSMD13 RELA PSMA7 PSMB10 PSMA8 IGKV1-12 PRKCQ PSMB6 PSMB7 PSMB4 UBE2D1 PSMB5 PSMB2 UBB IGKV2D-28 PSMB3 CDC34 IGKV4-1 CARD11 UBC BCL10 PSMB1 PSMF1 IGHE IGKV2D-30 RPS27A SHFM1 PSMB8 UBE2D2 PSMB9 MALT1 PSMC5 RASGRP4 PSMC6 PSMC3 PSMC4 PSMC1 IGKV3-11 PSMC2 IKBKB LYN CHUK UBE2N UBE2V1 NFKB1 IGKV2-28 IGKV3D-20 FBXW11 BTRC SKP1 PSMD8 PSMD9 TRAF6 IGKV5-2 PSMD6 TAB3 TAB2 PSMD7 TAB1 PSMD4 MAP3K7 PSMD5 PSMD2 GLYCOSPHINGOLIPID METABOLISM%REACTOME%R-HSA-1660662.5 Glycosphingolipid metabolism ESYT3 ESYT2 ESYT1 NEU2 NEU3 SMPD3 NEU1 SUMF2 SMPD2 B4GALNT1 SUMF1 GM2A SMPD4 SMPD1 UGCG ENPP7 GLB1 ARSA UGT8 GALC GLA GBA GBA2 B3GALNT1 GLTP CERK ARSJ ASAH1 HEXB STS ASAH2 ARSK HEXA ARSH PSAP ARSI ARSF ARSG ARSD ARSE ARSB CTSA CPTP GLB1L COENZYME A BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 72%196783 Coenzyme A biosynthesis PANK3 COASY PANK1 PPCDC SLC25A16 PPCS PANK4 PANK2 GDP-FUCOSE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 72%6787639 GDP-fucose biosynthesis TSTA3 FUOM GMDS FUK SLC35C1 FPGT NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%R-HSA-2197563.1 NOTCH2 intracellular domain regulates transcription MAML2 MAML3 CREB1 MAML1 FCER2 GZMB EP300 MAMLD1 RBPJ HES1 NOTCH2 HES5 SIGNALING BY RETINOIC ACID%REACTOME DATABASE ID RELEASE 72%5362517 Signaling by Retinoic Acid PDHB CYP26C1 RARA RARB DLD CRABP1 DHRS3 ALDH1A1 DHRS4 ALDH1A3 SDR16C5 DHRS9 ALDH1A2 RDH10 RDH16 RDH5 RDH14 RDH13 ALDH8A1 CRABP2 RDH11 FABP5 RXRG RXRB RXRA PDHA2 PDHA1 PPARD ADH1C DLAT ADH1A PDK4 PDK3 AKR1C3 PDK2 PDK1 PDHX CPT1A ADH4 CPT1B CYP26A1 RARG CYP26B1 DNA DAMAGE BYPASS%REACTOME DATABASE ID RELEASE 72%73893 DNA Damage Bypass POLK RPA1 POLE RPA2 POLD3 POLH POLD4 RFC1 MAD2L2 USP43 RPA3 POLD1 POLD2 ISG15 RFC5 REV1 RFC3 RFC4 DTL RFC2 USP10 RCHY1 UBA52 NPLOC4 CUL4A POLE4 SPRTN KIAA0101 UBE2B RAD18 WDR48 UBE2L6 POLE2 UBB TRIM25 POLE3 REV3L UBC CUL4B RPS27A VCP DDB1 RBX1 UFD1L POLI PCNA UBA7 USP1 SIGNALING BY WNT IN CANCER%REACTOME%R-HSA-4791275.2 Signaling by WNT in cancer PPP2CA PPP2CB PPP2R5B PORCN PPP2R5A TCF7L2 GSK3B PPP2R5C RNF43 PPP2R1B WNT3A PPP2R1A FZD4 FZD6 LRP5 FZD8 LRP6 APC CSNK1A1 CTBP1 PPP2R5D DKK1 CTBP2 DKK2 FZD5 DKK4 CTNNB1 TNKS TNKS2 KREMEN1 KREMEN2 AMER1 AXIN1 PPP2R5E REGULATION OF TP53 ACTIVITY THROUGH PHOSPHORYLATION%REACTOME%R-HSA-6804756.1 Regulation of TP53 Activity through Phosphorylation EXO1 RPA1 RPA2 TOPBP1 WRN RPA3 RMI2 RFC5 DNA2 RFC3 RMI1 RFC4 TOP3A RFC2 CCNA2 CCNA1 UBA52 TAF9B PRKAA1 PRKAA2 CSNK2A1 MRE11A TAF9 TAF1L CSNK2A2 HIPK1 AURKB AURKA TP53INP1 HIPK2 RBBP8 CSNK2B UBB TAF15 RAD1 TAF12 TAF13 UBC TAF10 TP53RK TAF11 NOC2L RPS27A SSRP1 STK11 KAT5 RAD50 CHEK2 CHEK1 NBN TAF7 TAF6 SUPT16H TAF5 TAF4 PRKAB2 TAF3 HUS1 TAF2 PRKAB1 TAF1 MAPK14 MAPK11 CDK5 MAPKAPK5 TP53 RHNO1 AK6 CDK5R1 NUAK1 BRIP1 ATRIP BARD1 PLK3 TBP TPX2 RAD17 ATM CDK2 MDM2 TAF4B ATR PIN1 MDM4 RAD9B RAD9A DYRK2 PRKAG1 PRKAG2 BRCA1 PRKAG3 TAF7L BLM TRANSFERRIN ENDOCYTOSIS AND RECYCLING%REACTOME%R-HSA-917977.1 Transferrin endocytosis and recycling ATP6V1B2 STEAP2 ATP6V0C ATP6V0D2 ATP6V1B1 ATP6V1A ATP6V0A2 ATP6V1H ATP6V0A4 ATP6V0E2 ATP6V1G3 ATP6V1D ATP6V1C1 ATP6V1F ATP6V0A1 ATP6V1C2 MCOLN1 TF TFRC STEAP3 HFE TCIRG1 ATP6V1E1 ATP6V1E2 ATP6V1G1 ATP6V0B ATP6V0E1 ATP6V1G2 ATP6AP1 TFR2 ATP6V0D1 GLUCONEOGENESIS%REACTOME%R-HSA-70263.2 Gluconeogenesis PGK1 PGK2 PCK1 PCK2 SLC25A1 GPI SLC37A1 MDH1 GOT1 ENO1 MDH2 ENO2 GOT2 ENO3 G6PC2 G6PC3 PC TPI1 G6PC PGAM1 PGAM2 GAPDHS ALDOC SLC25A10 ALDOB SLC25A12 ALDOA SLC25A11 GAPDH FBP1 FBP2 SLC25A13 UNWINDING OF DNA%REACTOME DATABASE ID RELEASE 72%176974 Unwinding of DNA MCM3 MCM4 MCM5 MCM6 MCM2 GINS1 GINS2 GINS3 CDC45 GINS4 MCM7 MCM8 G0 AND EARLY G1%REACTOME%R-HSA-1538133.3 G0 and Early G1 RBBP4 CCNE2 CDC6 CCNE1 LIN54 LIN52 RBL2 CCNA2 CCNA1 MYBL2 TFDP1 RBL1 LIN37 TFDP2 LIN9 E2F5 DYRK1A TOP2A E2F1 E2F4 CDK2 CDK1 HDAC1 MYC CDC25A MAX PCNA RIBOSOMAL SCANNING AND START CODON RECOGNITION%REACTOME DATABASE ID RELEASE 72%72702 Ribosomal scanning and start codon recognition RPS4X RPS3A FAU RPS27L RPS26 RPS25 RPS28 EIF1AX RPS27 RPS29 EIF2S2 RPS20 EIF2S1 RPS21 EIF5 RPS24 EIF2S3 RPS23 EIF4A2 EIF4H EIF4A1 EIF3M EIF3K EIF3L EIF3I EIF3J EIF3G EIF3H EIF3E EIF3F EIF3C EIF3D EIF3A RPS4Y2 EIF3B RPS4Y1 RPS27A RPS3 RPS2 EIF4E EIF4G1 RPS9 EIF4B RPS7 RPS8 RPS5 RPS6 RPSA RPS15 RPS14 RPS17 RPS16 RPS19 RPS15A RPS18 RPS11 RPS10 RPS13 RPS12 DEFECTIVE SLC2A10 CAUSES ARTERIAL TORTUOSITY SYNDROME (ATS)%REACTOME DATABASE ID RELEASE 72%5619068 Defective SLC2A10 causes arterial tortuosity syndrome (ATS) SLC2A10 SUMOYLATION OF CHROMATIN ORGANIZATION PROTEINS%REACTOME DATABASE ID RELEASE 72%4551638 SUMOylation of chromatin organization proteins SUMO2 L3MBTL2 CBX5 NUP107 NUP188 SUZ12 NUP62 NDC1 NUP214 SEC13 NUP133 NUP210 SATB1 BMI1 NUP93 RNF2 NUP50 CBX8 NUP54 PHC2 PHC1 RING1 CBX4 CBX2 PCGF2 PHC3 POM121 HIST1H4K NUP205 HIST1H4L AAAS NUP160 HIST1H4A ZBED1 NUP85 HIST1H4B TPR HIST1H4H HIST1H4I NUP88 HIST1H4J NUP43 HIST1H4C HIST1H4D RAE1 HIST1H4E RANBP2 HIST1H4F NUP155 CHD3 SATB2 NUP153 PIAS1 NUP35 NUPL2 NUP37 HDAC4 HIST4H4 UBE2I HDAC2 HDAC1 HIST2H4A SUMO1 HIST2H4B SUMO3 ENDOGENOUS STEROLS%REACTOME%R-HSA-211976.4 Endogenous sterols PTGIS CYP46A1 ARNT2 CYP51A1 AHR ARNT CYP11A1 NCOA1 POMC NCOA2 CYP21A2 AHRR FDXR CYP1B1 RXRA CYP11B2 CYP11B1 CYP7B1 CYP19A1 CYP4V2 NR1H4 CYP7A1 CYP39A1 FDX1 CYP8B1 FDX1L CYP27A1 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE%REACTOME%R-HSA-176407.3 Conversion from APC C:Cdc20 to APC C:Cdh1 in late anaphase ANAPC15 ANAPC16 FZR1 ANAPC7 UBE2C UBE2E1 UBE2D1 ANAPC10 ANAPC11 CDC23 CDC26 CDC27 CDC16 ANAPC4 ANAPC5 ANAPC1 CDC14A ANAPC2 CDC20 HDACS DEACETYLATE HISTONES%REACTOME DATABASE ID RELEASE 72%3214815 HDACs deacetylate histones RBBP4 SAP30L TBL1X SAP18 HIST2H2AB RBBP7 MTA2 MTA3 MBD3 ARID4B HIST1H2AE TBL1XR1 HIST1H2AD HIST3H2BB HIST2H2BF GATAD2B HIST1H2AC HIST1H2AB GATAD2A CHD4 HIST1H2AJ SAP30 HIST2H3A HIST1H2BF HIST1H2BE HIST1H2BH HIST1H2BG HIST2H3D HIST1H2BB HIST3H2A HIST1H2BA KDM1A HIST2H3C HIST1H2BD HIST1H2BC ARID4A HIST1H3J HIST1H3A HIST1H3F HIST1H2AG HIST1H3G HIST1H3H HIST1H2AA HIST1H3I SUDS3 HIST1H2AM HIST1H3B HIST1H2AL HIST1H3C GPS2 HIST1H3D HIST1H2AI HIST1H3E HIST1H2AH HIST1H4K HIST1H2AK HIST1H4L BRMS1 HIST1H4A HIST1H4B HIST1H4H HIST1H4I HIST1H4J HIST1H4C REST HIST1H4D HIST1H4E PHF21A HIST1H4F HIST2H2AA3 HIST2H2AA4 CHD3 HIST2H2AC NCOR2 NCOR1 HDAC3 HMG20B HDAC10 HIST2H2BE HIST4H4 HDAC8 HIST1H2BN HIST1H2BM HDAC2 HIST1H2BO HIST1H2BJ HDAC1 HIST1H2BI HIST1H2BL HIST1H2BK HIST2H4A HIST2H4B MTA1 INSULIN-LIKE GROWTH FACTOR-2 MRNA BINDING PROTEINS (IGF2BPS IMPS VICKZS) BIND RNA%REACTOME%R-HSA-428359.3 Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs IMPs VICKZs) bind RNA IGF2BP3 IGF2BP2 IGF2BP1 MAP2K AND MAPK ACTIVATION%REACTOME%R-HSA-5674135.2 MAP2K and MAPK activation MAP2K1 MAP2K2 BRAF RAF1 ITGA2B ARAF PEBP1 IQGAP1 ARRB2 KSR1 KSR2 APBB1IP CNKSR2 CNKSR1 VCL ARRB1 RAP1B FGB MARK3 HRAS FGA FN1 VWF RAP1A FGG LAMTOR2 NRAS ITGB3 LAMTOR3 YWHAB WDR83 IL17RD SRC MAPK1 CSK MAPK3 TLN1 BINDING OF TCF LEF:CTNNB1 TO TARGET GENE PROMOTERS%REACTOME DATABASE ID RELEASE 72%4411364 Binding of TCF LEF:CTNNB1 to target gene promoters AXIN2 LEF1 RUNX3 TCF7 TCF7L2 TCF7L1 MYC CTNNB1 INTERLEUKIN RECEPTOR SHC SIGNALING%REACTOME DATABASE ID RELEASE 72%912526 Interleukin receptor SHC signaling IL3RA IL2RB INPPL1 PIK3CD INPP5D SHC1 PTPN6 JAK2 PIK3R1 PIK3R2 PIK3CA SOS1 PIK3R3 CSF2RB CSF2 CSF2RA GAB2 IL2 PIK3CB IL2RG JAK1 JAK3 IL2RA IL5RA IL3 IL5 AMINE OXIDASE REACTIONS%REACTOME%R-HSA-140179.1 Amine Oxidase reactions MAOB MAOA PAOX POU5F1 (OCT4), SOX2, NANOG REPRESS GENES RELATED TO DIFFERENTIATION%REACTOME DATABASE ID RELEASE 72%2892245 POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation SOX2 NANOG POU5F1 RUNX1 REGULATES GENES INVOLVED IN MEGAKARYOCYTE DIFFERENTIATION AND PLATELET FUNCTION%REACTOME DATABASE ID RELEASE 72%8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function ASH2L PRMT6 TNRC6C TNRC6A TNRC6B KMT2E KMT2D KMT2A KMT2C KMT2B MYL9 DPY30 WDR5 MOV10 AGO3 AGO4 AGO1 RBBP5 PRMT1 ITGA2B CBFB RUNX1 HIST1H2AE HIST1H2AD HIST3H2BB HIST1H2AC HIST1H2AB HIST1H2AJ HIST2H3A HIST1H2BF HIST1H2BE PRKCQ ZFPM1 HIST1H2BH EP300 HIST1H2BG GATA1 HIST2H3D NFE2 HIST1H2BB HIST1H2BA HIST2H3C HIST1H2BD HIST1H2BC H2AFB1 GP1BA HIST1H3J HIST1H3A HIST1H3F HIST1H3G HIST1H3H HIST1H3I NR4A3 HIST1H3B HIST1H3C HIST1H3D HIST1H3E H3F3B HIST1H4K PF4 HIST1H4L H3F3A H2BFS HIST1H4A HIST1H4B HIST1H4H HIST1H4I HIST1H4J HIST1H4C HIST1H4D HIST1H4E HIST1H4F HIST2H2AA3 HIST2H2AA4 HIST2H2AC SIN3B H2AFJ SIN3A H2AFZ H2AFX THBS1 H2AFV HIST2H2BE KAT2B HIST4H4 HIST1H2BN HIST1H2BM HIST1H2BO HIST1H2BJ HDAC1 HIST1H2BI HIST1H2BL HIST1H2BK SETD1B SETD1A HIST2H4A HIST2H4B DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA%REACTOME DATABASE ID RELEASE 72%3359454 Defective TCN2 causes hereditary megaloblastic anemia TCN2 GLYOXYLATE METABOLISM AND GLYCINE DEGRADATION%REACTOME DATABASE ID RELEASE 72%389661 Glyoxylate metabolism and glycine degradation PDHB NDUFAB1 DBT PRODH2 DLD LIAS AMT GOT2 AGXT DDO OGDH GLDC HAO1 GCSH PDHA2 PDHA1 DHTKD1 LIPT2 GRHPR LIPT1 DLAT AGXT2 BCKDHA DAO PXMP2 DLST BCKDHB HOGA1 PDHX GNMT ALDH4A1 ADHERENS JUNCTIONS INTERACTIONS%REACTOME%R-HSA-418990.2 Adherens junctions interactions PVRL1 CDH1 CDH4 CDH2 PVR CDH15 CDH9 CTNNA1 CDH8 CDH7 CDH6 PVRL2 CDH3 JUP CDH10 CDH11 CTNNB1 CDH12 CTNND1 CDH13 ANG CDH5 CDH17 CDH18 CDH24 CADM3 CADM2 CADM1 PVRL4 PVRL3 AXONAL GROWTH INHIBITION (RHOA ACTIVATION)%REACTOME DATABASE ID RELEASE 72%193634 Axonal growth inhibition (RHOA activation) OMG MAG LINGO1 MCF2 NGFR ARHGDIA RHOA RTN4 TALDO1 DEFICIENCY: FAILED CONVERSION OF SH7P, GA3P TO FRU(6)P, E4P%REACTOME DATABASE ID RELEASE 72%6791055 TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P TALDO1 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL%REACTOME%R-HSA-1855204.3 Synthesis of IP3 and IP4 in the cytosol INPPL1 INPP5B PLCG2 INPP5D PLCD3 INPP5J PLCD4 PLCD1 OCRL PLCG1 PLCH1 PLCH2 SYNJ1 ITPK1 PLCE1 ITPKB ITPKC PLCB3 PLCB4 ITPKA PLCB1 PLCB2 PLCZ1 PLD4 PTEN REGULATION OF GLYCOLYSIS BY FRUCTOSE 2,6-BISPHOSPHATE METABOLISM%REACTOME DATABASE ID RELEASE 72%9634600 Regulation of glycolysis by fructose 2,6-bisphosphate metabolism PPP2CA PPP2CB PPP2R5D PPP2R1B PFKFB2 PPP2R1A PFKFB1 PRKACG PRKACA PFKFB4 PRKACB PFKFB3 PTK6 REGULATES CELL CYCLE%REACTOME%R-HSA-8849470.1 PTK6 Regulates Cell Cycle CDKN1B PTK6 CDK4 CCNE1 CDK2 CCND1 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT%REACTOME%R-HSA-1428517.1 The citric acid (TCA) cycle and respiratory electron transport ATP5G2 UQCR11 NDUFA7 ATP5G1 UQCR10 NDUFA6 NDUFA5 NDUFA3 ATP5F1 NDUFA2 MPC1 NDUFA1 ATP5C1 MPC2 ETFDH NDUFAF6 NDUFAF7 NDUFAF4 NDUFAF5 NDUFAF2 OGDH NDUFAF3 TMEM126B NDUFAF1 LDHAL6A LDHAL6B MT-ND6 MT-ND4 MT-ND5 ATP5S MT-ND2 MT-ATP6 MT-ND3 MT-ND1 ATP5J ATP5I IDH3B ATP5H ATP5O IDH3A ATP5L ATP5B NDUFA4 ATP5E MT-CO1 ATP5D UQCRC1 MT-ATP8 UQCRC2 ADHFE1 PDHB COX7A2L SCO1 TIMMDC1 SCO2 MT-CO2 MT-CO3 IDH3G MDH2 SDHC SDHD SDHA SDHB NDUFB10 NDUFB11 SURF1 ACAD9 CS RXRA GLO1 L2HGDH PDHA2 PDHA1 PPARD COX7B PDK4 PDK3 NUBPL ATP5A1 ECSIT PDK2 DLST PDK1 PDHX COX7C SUCLG2 SUCLG1 COX8A DLD FH UCP1 COX5B COX5A UCP3 FAHD1 UCP2 PM20D1 CYC1 NDUFV3 NDUFV2 SLC16A1 UQCRB NDUFV1 COX6C LRPPRC UQCRH SLC16A8 SLC16A3 UQCRFS1 TACO1 COX6A1 UQCRQ ACO2 NDUFS8 LDHC NDUFS7 MT-CYB NDUFS6 LDHB NDUFS5 LDHA VDAC1 NDUFS4 PDPR ETFA NDUFS3 ETFB NDUFAB1 COX6B1 NDUFS2 NDUFS1 COX16 COX18 PDP1 ME1 COX11 ME3 PDP2 COX14 ME2 NDUFC2 NDUFA13 NDUFC1 NDUFA11 NDUFA12 TRAP1 NDUFA10 COQ10B COQ10A SLC25A14 ATP5J2 NDUFB9 NDUFB8 NDUFB7 NDUFB6 GSTZ1 NDUFB5 SUCLA2 NDUFB4 NDUFB3 NDUFB2 IDH2 NNT NDUFB1 CYCS DLAT BSG COX20 SLC25A27 D2HGDH COX4I1 NDUFA9 ATP5G3 NDUFA8 STAT6-MEDIATED INDUCTION OF CHEMOKINES%REACTOME%R-HSA-3249367.1 STAT6-mediated induction of chemokines STAT6 TBK1 TMEM173 G ALPHA (I) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 72%418594 G alpha (i) signalling events CXCL6 GRM7 CXCL9 GRM6 PRKAR2B CXCL3 GPER1 CXCL13 GRM8 PRKAR2A CXCL2 CX3CL1 SSTR1 CXCL5 SSTR2 CXCL16 SSTR4 SSTR5 CCR9 CNR2 CCR8 GNAS CNR1 HTR1E CCR7 TAS1R2 HTR1F CCR6 TAS1R1 HTR1D CCR4 TAS1R3 CCR3 HTR1A CCR2 OPN1SW HTR1B RXFP4 CX3CR1 RXFP3 CCL13 HTR5A ADCY4 CXCR5 PLB1 GALR3 ADCY3 CXCR6 GALR2 APP GALR1 ADCY2 CCL5 ADCY1 CXCR3 ADCY8 CCL4 ADCY7 GPR183 ADCY6 PNOC ADCY5 CCL1 CCL19 OPN1LW CCL16 OPN1MW CCR10 RGR CCL25 CCR1 HCAR2 SSTR3 HCAR3 CCL21 HCAR1 CCL20 CXCL10 CXCL11 CHRM4 LRAT ACKR3 CCL28 GUCA1B MCHR1 CCL27 GUCA1A GUCA1C HSPG2 MTNR1A MTNR1B RBP4 PPEF1 RBP2 RBP1 STRA6 PPP3CC PPP3R1 INSL5 RCVRN METAP1 METAP2 NMT1 RRH RETSAT GPR37L1 NMT2 PPY NMS NMU NPB GUCY2D GPIHBP1 PTGER3 PLA2G4A GUCY2F NPW CCL4L2 PMCH NPY2R SDR9C7 NPY1R RGS9BP APLNR SUCNR1 AWAT2 OPN3 C3 OPN5 PYY NMUR2 NMUR1 GPSM1 TAS2R7 GPSM2 TAS2R9 TAS2R8 HEBP1 PDE4B BDKRB2 BDKRB1 TAS2R1 TAS2R3 GPSM3 TAS2R5 TAS2R4 NPY5R CORT RGS18 RGS14 RGS13 NPY4R OPRL1 RGS21 S1PR3 CAMK4 RGS22 S1PR2 S1PR5 S1PR4 OPRK1 KNG1 RGS10 RGS12 GNAT2 GNAT3 HRH3 HRH4 GNAT1 RGS9 RGS6 RGS7 GNAZ PF4 GNG10 GNG12 GNG11 GNG13 GNAO1 GNB2 GNB1 GNB4 GNB3 GNB5 GNGT1 GNGT2 LRP1 PPP3CA GNAI3 PPP3CB GNAI1 GNAI2 GNG3 CHRM2 GNG2 GNG5 GNG4 LRP2 GNG7 GNG8 LRP8 RGS11 CXCL8 PPP2R1B PPP2R1A PRKACG PRKACA PRKACB RDH11 PPP2R5D GPR17 PPP2CA PPP2CB CAMKK1 CAMKK2 GABBR2 GABBR1 GPC1 GPC3 AHCYL1 GPC2 GPC5 GPC4 GPC6 AKR1C1 AKR1C3 AKR1C4 CXCL12 PPP1CA AGRN DHRS3 GNAL ITPR1 NBEA CCR5 DHRS9 ITPR2 CXCR4 ITPR3 RDH10 RDH16 RDH5 CREB1 MAPK1 ABCA4 CDK5 RGS17 RGS19 RGSL1 RGS16 RGS4 RGS20 CLPS CAMK2B SDC4 CAMK2D SDC2 CAMK2A SDC3 APOM APOE CAMK2G APOB PRKCG SDC1 PLCB3 PLCB4 PLCB1 PLCB2 HSD17B1 RLN3 ANXA1 AGT PRKX PSAP C3AR1 ADRA2C ADRA2A FNTA PRKCQ PDE4A PDE4D PDE4C FPR1 FPR2 AKR1B10 LDLR NPY DRD3 DRD4 PPBP APOA2 APOA1 OPRD1 APOA4 CYP4V2 SLC24A1 PDE6G CNGA1 RHO OPRM1 SAG PDE6B PDE6A CNGB1 TTR S1PR1 BCO2 BCO1 CXCR1 CXCR2 APOC3 APOC2 POMC SAA1 PDE1B PDE1A C5AR1 C5 CXCL1 P2RY12 SRC PRKCD P2RY13 PRKCA P2RY14 P2RY4 ADORA3 ADORA1 PDE1C ADRBK1 PDYN RBP3 AGTR2 FPR3 RDH12 NPBWR1 NPBWR2 NAPEPLD GPR18 GPR37 KPNA2 GPR31 GPR55 FNTB RLBP1 APLN OPN1MW2 TAS2R20 OXER1 TAS2R10 TAS2R13 TAS2R14 TAS2R16 MYO7A TAS2R19 TAS2R40 TAS2R41 TAS2R42 TAS2R43 TAS2R46 LPAR1 LPAR2 LPAR3 PENK TAS2R30 TAS2R31 TAS2R38 TAS2R39 RPE65 LPAR5 PPP1R1B PNLIP TAS2R60 PTGDR2 OXGR1 LPL TAS2R50 GAL HSD17B6 RGS5 RGS3 RGS1 RGS8 CASR CAMKMT PCP2 MCHR2 GRK1 GRK7 LRP10 LRP12 ADCY9 GRM3 PRKAR1B PRKAR1A GRM2 SST GRM4 SYNTHESIS OF PA%REACTOME DATABASE ID RELEASE 72%1483166 Synthesis of PA DDHD1 GPAM LPCAT4 GPD1L ALPI LPCAT1 LCLAT1 LIPI ACP6 LIPH FAM73A FAM73B PLA2G12A PLA2G4D PLA2G4B PLA2G4A GNPAT GPD2 AGPAT5 PLA2G10 AGPAT6 GPD1 AGPAT9 PLA2G1B AGPAT1 AGPAT2 PLA2R1 AGPAT3 AGPAT4 GPAT2 PLA2G2F PLD6 PLA2G5 PLA2G2D PLD1 PLA2G2E PLD2 PLA2G2A DDHD2 G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA%REACTOME DATABASE ID RELEASE 72%392451 G beta:gamma signalling through PI3Kgamma PDPK1 GNG11 AKT1 GNG13 GNB2 GNB1 GNB4 GNB3 GNB5 PIK3CG GNGT1 GNGT2 GNG3 GNG2 RHOA PIK3R6 GNG5 PIK3R5 GNG4 GNG7 GNG8 AKT2 AKT3 GNG10 GNG12 CLEARANCE OF DOPAMINE%REACTOME%R-HSA-379401.2 Clearance of dopamine MAOA LRTOMT COMT SLC6A3 GLI3 IS PROCESSED TO GLI3R BY THE PROTEASOME%REACTOME DATABASE ID RELEASE 72%5610785 GLI3 is processed to GLI3R by the proteasome PSMD3 CUL1 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 GLI3 PSMA2 PSME3 SUFU PSME4 PSME1 PSME2 UBA52 PSMD10 PSMB11 PSMD12 PRKACG PSMD11 PRKACA PSMD14 PRKACB PSMD13 PSMA7 PSMB10 CSNK1A1 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 UBB PSMB3 UBC PSMB1 PSMF1 RPS27A SHFM1 PSMB8 PSMB9 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 GSK3B BTRC SKP1 PSMD8 PSMD9 PSMD6 RBX1 PSMD7 PSMD4 PSMD5 PSMD2 PROTEIN LOCALIZATION%REACTOME DATABASE ID RELEASE 72%9609507 Protein localization ATP5G1 ACOT4 CHCHD4 SCP2 DECR2 CHCHD5 CHCHD2 CHCHD7 GSTK1 TIMM17A TIMM17B COA6 CMC4 CMC2 PAM16 DDO TIMM23 TIMM22 TIMM21 APP BCS1L COX19 TIMM9 COX17 TIMM13 ACBD5 TIMM10 TIMM50 GRPEL1 EPHX2 PITRM1 GRPEL2 CROT LDHD TIMM8B COA4 GNPAT DNAJC19 TIMM8A CHCHD10 BAAT TIMM44 GFER TIMM10B ATP5B HSD17B4 SLC25A12 EMD USP9X SLC25A13 ABCD1 NUDT7 OTC ZFAND6 PEX26 IDE SEC61G MPV17 SEC61B ECH1 EHHADH PEX11B BAG6 OTOF FIS1 PXMP4 STX5 HSCB GET4 CAMLG PEX1 PEX7 IDH3G PEX6 WRB ASNA1 UBL4A PEX10 TAZ ATAD1 PEX12 VAPA PEX16 PEX13 SGTA PEX14 GDAP1 TOMM20 TOMM22 PEX2 HAO1 NOS2 HAO2 AGPS CS PMPCB PMPCA ATP5A1 CHCHD3 TOMM40 CRAT TOMM70A ACOX2 ACOX3 TOMM7 TOMM5 TOMM6 ACAA1 NUDT19 SAMM50 STX1A HSPA9 VAMP2 MTX1 MTX2 DHRS4 UBA52 CYC1 SLC27A2 LONP2 UBE2D1 PECR UBB UBC RPS27A PIPOX ACO2 UBE2D2 UBE2D3 HACL1 VDAC1 HMOX1 ACOT2 ABCD2 PAOX ABCD3 PEX3 HMGCL AGXT PEX19 FXN ACOX1 TYSND1 PRNP SLC25A17 PHYH HSPD1 SLC25A4 SLC25A6 NDUFB8 SERP1 IDH1 ACOT8 COQ2 AMACR DAO PXMP2 CAT REGULATION OF IFNA SIGNALING%REACTOME DATABASE ID RELEASE 72%912694 Regulation of IFNA signaling IFNA4 USP18 IFNA7 IFNA6 IFNA1 IFNA2 IFNA8 STAT2 PTPN11 IFNA13 SOCS1 IFNA14 IFNA16 IFNA17 SOCS3 IFNA10 IFNAR1 IFNA21 TYK2 PTPN6 PTPN1 JAK1 IFNB1 IFNA5 DEFECTIVE CYP26B1 CAUSES RADIOHUMERAL FUSIONS WITH OTHER SKELETAL AND CRANIOFACIAL ANOMALIES (RHFCA)%REACTOME%R-HSA-5579015.1 Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA) CYP26B1 MICROTUBULE-DEPENDENT TRAFFICKING OF CONNEXONS FROM GOLGI TO THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 72%190840 Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane GJA1 CYTOKINE SIGNALING IN IMMUNE SYSTEM%REACTOME%R-HSA-1280215.4 Cytokine Signaling in Immune system CUL1 CAPZA1 IRAK3 SIGIRR FOXO1 CD86 LCK CD80 FOXO3 BCL2L1 BCL2 PPIA IQGAP1 SPRED3 SPRED2 SPRED1 SYNGAP1 HRAS RASA3 RASA4 RASA1 RASA2 CUL3 RASAL1 RASAL2 RASAL3 NRAS DAB2IP NF1 KBTBD7 ARF1 RPLP0 CSH1 PRL PRLR GHR GH2 GH1 PDGFRB KIT PDGFB PTGS2 IL21 IL21R SOX2 RORA THEM4 KPNB1 MYC PIK3CD EGF SHC1 GAB1 PIK3R1 CBL EGFR PIK3CA PLCG1 SOS1 PIK3C3 TGFB1 MT2A IFNB1 VEGFA SMARCA4 TNFRSF6B TNFSF11 TNFRSF8 TNFRSF4 CXCL8 EDAR TNFRSF11B TNFRSF11A TNFRSF17 TNFRSF14 SOD1 TNFSF18 TNFSF14 TNFSF15 TNFSF12 JAK2 TNFRSF9 TNFSF4 UBA3 TNFSF9 CD27 FGF6 TNFSF8 FGF9 MAP3K14 FGF20 UBE2M EDA FGF1 TNFRSF13B TEC FGF2 TNFRSF13C FGF23 EDA2R FGF3 TNFSF13B FGF22 RELA FGF10 EDARADD TNFRSF12A FGF4 TNFRSF18 TNFRSF1B LTA TNFRSF25 LTB RELB PIK3R4 CD70 PIK3R3 CD40LG BLNK LTBR CTSG CCND1 NFKB1 NFKB2 CD36 BRWD1 CIITA IFI30 ICAM1 TRIM8 TRIM6 CD44 TRIM5 TRIM29 TRIM2 TRIM3 TRIM68 TRIM26 TRIM22 HLA-DPA1 GBP6 GBP5 TRIM62 GBP7 ITGB3 MID1 TRIM17 IRF4 PIK3CB IRF1 IRF2 IRF8 AKT2 TRIM14 IRF5 IRF6 TRIM10 GATA3 IRF9 HLA-DQB2 POU2F1 HLA-DQB1 SP100 PTAFR TRIM46 PDPK1 NCAM1 TRIM48 GBP2 FCGR1B VAV1 GBP1 HLA-DQA2 MAPKAPK3 GBP4 HLA-DQA1 GBP3 TRIM45 TRIB3 HLA-DRB5 CRK VCAM1 HLA-DRB4 SHC2 TRIM35 HLA-DPB1 HLA-DRA TRIM38 TRIM31 HLA-DRB3 CCR5 HLA-DRB1 TRIM34 PIK3R2 CDC42 PTK2B FYN PAK2 PTK2 IFITM3 IFITM1 IFITM2 IFI35 IFIT3 IFIT2 RSAD2 BST2 IFNA5 IFNA4 IFNA7 IFNA6 IFNA1 IFNA2 IFNA8 IFI6 STAT2 IFNA13 IFNA14 IFNA16 IFNA17 SAMHD1 IFNA10 IFNAR1 IFNA21 ISG20 XAF1 ADAR FASLG TRAF2 TNF RASGRF2 CANX CASP3 RASGRP1 RASGRP3 IGHG4 IGHG1 TNFRSF1A SOS2 BIRC2 BIRC3 ADAM17 LYN LMNB1 YES1 IL6 ANXA1 ANXA2 IL10 SYK IL4 AIP HCK IL18RAP IL37 IL13 IL18R1 IL18BP HSP90B1 FCGR1A IL18 IL1A IL1B PTPN13 WDR83 PAQR3 BRAP RET GFRA3 IL17RD RAPGEF2 IL5RA FPR1 SHC3 RASGRP4 IL5 MAP3K11 RASGEF1A IL3RA IL2RB MAOA INPP5D MUC1 TLN1 ITGAM ITGB2 MAP2K1 MAP2K2 BRAF RAF1 ITGAX IL20RA IL20RB IL22RA2 IL22RA1 TIMP1 HAVCR2 ZEB1 STX3 IL10RB IL10RA CSF3 CSF3R CSF1 RORC PIM1 IL13RA2 IL13RA1 TXLNA FSCN1 CSF1R NDN SOCS5 MCL1 MIF CEBPD PTPRZ1 CD4 LGALS9 IL15RA STXBP2 TWIST1 IFNLR1 GRB2 IL22 IL20 IL25 IL26 CSF2RB IL24 IL15 CSF2RA IL19 IL16 IL17RE IL17RC IL17RB IL17RA IGHE OPRD1 IL32 IL34 BATF IL17F IL17C IL17A IL4R IL9 MMP1 MMP2 MMP3 OPRM1 IL9R IFNL2 IFNL1 S1PR1 IFNL3 TP53 LCN2 POMC JUN CNN2 CDKN1A HLA-A B2M CXCL1 MMP9 SNAP25 IL3 NANOG STX1A ITGA2B ARAF VAMP2 PEBP1 ARRB2 KSR1 KSR2 APBB1IP CNKSR2 CNKSR1 COL1A2 VCL RAP1B MARK3 FN1 EIF4A2 EIF4A1 EIF4E3 UBE2L6 IFIT1 LAMTOR2 OASL HERC5 CSF2 TRIM25 KPNA7 KPNA4 LAMTOR3 ARIH1 KPNA5 KPNA2 IL2 KPNA3 JAK1 DDX58 PPM1B IL2RA OAS1 RAG2 IRF3 RAG1 PDE12 OAS2 OAS3 USP41 EIF4E2 RNASEL UBA7 USP18 FLNA FLNB EIF4E STAT1 MX2 MX1 FRS2 EIF2AK2 FRS3 ISG15 NEDD4 FGF16 UBE2N FGF7 FGF18 ABCE1 EIF4G3 EIF4G2 PDGFRA MAP2K6 BCL6 PIN1 CASP1 CXCL2 CCR2 PPP2R5C CCL11 CCL3L1 CCL3L3 BIRC5 APP CCL5 CCL4 CCL3 ARRB1 CCL2 CCL19 CCR1 CCL22 CCL20 VAMP7 CXCL10 PML STX4 TRAF3 BTC EPGN TGFA AREG HBEGF EREG HSPA9 SOD2 F13A1 NFKBIA IKBKG FGB FGA VWF UBE2E1 STAT5A STAT5B SOCS3 FGG IRS1 IRS2 PRTN3 TCP1 STAT3 IL7R NUP107 NUP188 KPNA1 ACTN2 PPP2R1B PPP2R1A NUP62 PRKACA NDC1 NUP214 SEC13 NUP133 NUP210 PPP2R5D GRIN2B GRIN2D NUP93 NUP50 NUP54 POM121 NUP205 AAAS NUP160 PPP2CA PPP2CB NUP85 NEFL TPR NUP88 NUP43 RAE1 RANBP2 LRRC7 NUP155 NUP153 GSTO1 NUP35 NUPL2 NUP37 GRIN1 SUMO1 CFL1 DLG2 DLG3 RASGRF1 ATF1 ATF2 ELK1 RPS6KA3 RPS6KA5 RPS6KA2 RPS6KA1 JUNB DUSP4 MEF2A HGF MEF2C MET DUSP3 RAP1A CRKL FOS IL1RAPL1 VRK3 DUSP6 DUSP7 IP6K2 CREB1 MAPKAPK2 HLA-B MAPK7 MAPK1 HLA-C EIF4A3 MAPK3 EGR1 HLA-F HLA-G HLA-E MAPK14 MAPK11 HSP90AA1 ERBB2 ITGB1 ANGPT1 TALDO1 TEK LBP CAMK2B RAPGEF1 LAMA5 CAMK2D CAMK2A RANBP9 CAMK2G PTPN2 DLG1 DLG4 IL23R IL27 IL27RA IL12B SDC1 IL12A SERPINB2 IL23A BOLA2 SNRPA1 LCP1 RALA EBI3 BOLA2B HNRNPDL STAT4 IL12RB1 IL12RB2 MSN HNRNPF HNRNPA2B1 PDCD4 IL2RG SOCS2 JAK3 TSLP CISH IL7 CRLF2 DUSP5 DUSP2 DUSP1 DUSP8 DUSP9 INPPL1 DUSP16 DUSP10 PEA15 PHB FBXW11 SOCS1 IFNG IFNGR1 IFNGR2 PITPNA CA1 SPTAN1 HIST2H3A PPP5C HIST2H3D HIST2H3C MTAP HIST1H3J HIST1H3A VIM HIST1H3F HIST1H3G HIST1H3H HIST1H3I HIST1H3B HIST1H3C HIST1H3D HIST1H3E HMOX1 NRTN GFRA1 SPTB GFRA2 GFRA4 SPTBN4 SPTBN5 SPTA1 SPTBN1 PIAS1 SPTBN2 PSPN GDNF PTPRA ARTN TBK1 TRIM21 IRF7 ALOX5 STAT6 MAPK8 IL1RN IL36A IL36B IL1R1 IL1R2 IL36RN IL36G IL1F10 TOLLIP PTPN20 PTPN23 IL1RL1 IL1RL2 MAP3K3 IL33 PTPN18 PTPN14 PTPN9 PTPN7 PTPN4 PTPN5 HMGB1 IKBKB FCER2 NKIRAS1 NKIRAS2 MAP3K8 MAP2K3 CHUK MAP2K4 RIPK2 IRAK4 PELI1 TLR9 UBE2V1 PELI3 PELI2 NOD1 NOD2 AGER MAPK9 IRAK1 S100A12 MAP2K7 S100B MAPK10 TNIP2 SAA1 MYD88 NFKBIB NOS2 YWHAB PSMD8 PSMD9 PSMD6 SRC PSMD7 PSMD4 PSMD5 CSK PSMD2 PPP2R5E PSMD3 AKT1 PSMD1 PTPN12 PPP2R5B PRKCD PPP2R5A YWHAZ PTPN11 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PTPN6 PSME1 PSME2 UBA52 SMAD3 PSMD10 RHOU PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 KLB FLT3 UBB PSMB3 PDE3B FLT3LG UBC PSMB1 GAB2 PSMF1 FGF19 FGFR4 RPS27A HSPA8 SHFM1 TNFSF13 PSMB8 PSMB9 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 EIF4G1 NRG1 NRG2 NRG3 NRG4 HIF1A PTPN1 GSTA2 IL11 ALOX15 CNTFR CNTF IL31 CTF1 IL11RA LIF OSM IL31RA LIFR TYK2 P4HB OSMR CLCF1 IL6ST IL6R CRLF1 BTRC SKP1 IRAK2 TRAF6 RBX1 TAB3 SQSTM1 TAB2 TAB1 MAP3K7 SHC-MEDIATED CASCADE:FGFR3%REACTOME%R-HSA-5654704.2 SHC-mediated cascade:FGFR3 HRAS FGF9 SOS1 FGF20 FGF16 FGF1 FGF2 FGF18 FGF23 NRAS FGF4 RNA POLYMERASE III TRANSCRIPTION%REACTOME%R-HSA-74158.2 RNA Polymerase III Transcription POLR2E POLR2F POLR2H GTF3C1 GTF3C2 GTF3C3 GTF3C4 POLR2K GTF3C5 POLR2L GTF3C6 SNAPC5 SNAPC1 SNAPC2 SNAPC3 SNAPC4 ZNF143 BRF2 BRF1 GTF3A BDP1 TBP CRCP SSB NFIX NFIA NFIB POLR1C NFIC POLR3GL POLR3A POLR3B POLR3C POLR3D POU2F1 POLR3E POLR3F POLR3G POLR3H POLR3K INTERFERON ALPHA BETA SIGNALING%REACTOME%R-HSA-909733.2 Interferon alpha beta signaling GBP2 PTPN11 PTPN6 IFIT1 OASL SOCS3 IP6K2 JAK1 IFITM3 OAS1 IFITM1 IRF3 IFITM2 IFI35 OAS2 PSMB8 IFIT3 HLA-B OAS3 IFIT2 RSAD2 HLA-C RNASEL BST2 IFNA5 HLA-F EGR1 IFNA4 HLA-G USP18 IFNA7 HLA-E IFNA6 IFNA1 IFNA2 IFNA8 MX2 IFI6 MX1 STAT2 IFNA13 ISG15 IFNA14 IFNA16 IFNA17 SAMHD1 ABCE1 IFNA10 IFNAR1 IFNA21 ISG20 XAF1 ADAR PTPN1 SOCS1 IRF7 TYK2 HLA-A IRF4 IRF1 IRF2 IRF8 IRF5 IFNB1 IRF6 IRF9 RECYCLING PATHWAY OF L1%REACTOME%R-HSA-437239.1 Recycling pathway of L1 RPS6KA4 DNM1 DNM3 SHTN1 EZR RPS6KA6 NUMB KIF4B KIF4A RPS6KA3 DPYSL2 RPS6KA5 RPS6KA2 RPS6KA1 SH3GL2 RDX MSN L1CAM CLTC DNM2 CLTA AP2A1 AP2B1 AP2A2 AP2S1 AP2M1 MAPK1 ER TO GOLGI ANTEROGRADE TRANSPORT%REACTOME DATABASE ID RELEASE 72%199977 ER to Golgi Anterograde Transport CNIH3 MCFD2 RAB1B SEC24B PPP6C DCTN4 PPP6R1 SEC24A PPP6R3 TRAPPC6A TRAPPC6B ANK2 ARCN1 GORASP1 CAPZA3 ANK3 SEC22A SEC22C CAPZA1 CAPZA2 FOLR1 COPG2 BET1 NSF COPG1 SEC24D ACTR10 SEC24C DYNC1LI1 DYNC1LI2 ARF4 CTSZ SAR1B SEC13 NAPA DYNLL2 CTSC NAPB GOSR1 NAPG GBF1 DYNC1I1 GOLGA2 GOLGB1 STX5 YKT6 COG8 COG7 COG6 COG5 COG4 COG3 ACTR1A COG2 COG1 BET1L TMED2 CSNK1D TGFA AREG DYNLL1 ARF3 ARF1 CD59 CD55 DYNC1I2 DCTN2 DCTN3 DYNC1H1 SPTAN1 COL7A1 F5 F8 SEC31A KDELR1 TRAPPC4 ANK1 KDELR2 SERPINA1 INS COPB2 SPTB COPA TMED10 SPTBN4 COPB1 SPTBN5 SPTA1 SPTBN1 SPTBN2 DCTN1 TFG LMAN1L GOSR2 LMAN2L COPE SCFD1 MIA2 SEC23A MIA3 CAPZB TMED3 STX17 USO1 LMAN1 LMAN2 TMED7 TMED9 COPZ2 TRAPPC10 SEC23IP ARFGAP3 TRAPPC2L TBC1D20 ARFGAP1 COPZ1 TRAPPC2 ARFGAP2 ANKRD28 TRAPPC3 SEC16B SEC16A SEC22B PREB TRAPPC5 TRAPPC9 ARF5 TRAPPC1 CNIH1 KDELR3 TMEM115 DCTN6 GRIA1 RAB1A CNIH2 DCTN5 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS%REACTOME DATABASE ID RELEASE 72%1971475 A tetrasaccharide linker sequence is required for GAG synthesis SDC4 SDC2 SDC3 B3GALT6 B4GALT7 B3GAT3 B3GAT2 B3GAT1 SDC1 XYLT2 XYLT1 GPC1 GPC3 GPC2 GPC5 BCAN GPC4 VCAN GPC6 NCAN BGN HSPG2 CSPG5 CSPG4 DCN AGRN SYNTHESIS OF DNA%REACTOME DATABASE ID RELEASE 72%69239 Synthesis of DNA LIG1 CUL1 RPA1 POLE RPA2 POLD3 RFC1 POLD4 RPA3 POLD1 POLD2 DNA2 RFC5 RFC3 RFC4 RFC2 CCNA2 CCNA1 POLE4 POLE2 POLE3 FZR1 GINS1 GINS2 GINS3 GINS4 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 UBA52 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 ANAPC15 ANAPC16 PSMB6 ANAPC7 UBE2C PSMB7 UBE2E1 PSMB4 UBE2D1 ANAPC10 PSMB5 ANAPC11 PSMB2 UBB CDC23 PSMB3 CDC26 CDC27 UBC CDC16 PSMB1 ANAPC4 PSMF1 ANAPC5 ANAPC1 RPS27A ANAPC2 SHFM1 PSMB8 PSMB9 SKP2 PSMC5 PSMC6 PSMC3 ORC5 PSMC4 ORC4 PSMC1 ORC6 PSMC2 ORC1 ORC3 ORC2 CDT1 CCNE2 CDC6 CCNE1 POLA1 POLA2 MCM7 MCM8 MCM3 MCM4 MCM5 MCM6 MCM2 PRIM2 PRIM1 CDC45 CDK2 SKP1 RBX1 FEN1 PCNA MAPK1 (ERK2) ACTIVATION%REACTOME DATABASE ID RELEASE 72%112411 MAPK1 (ERK2) activation JAK2 IL6R JAK1 MAP2K2 IL6 PTPN11 MAPK1 TYK2 GLYCINE DEGRADATION%REACTOME DATABASE ID RELEASE 72%6783984 Glycine degradation GCSH DLD GLDC AMT PROTON-COUPLED MONOCARBOXYLATE TRANSPORT%REACTOME DATABASE ID RELEASE 72%433692 Proton-coupled monocarboxylate transport SLC16A7 SLC16A8 EMB SLC16A3 BSG SLC16A1 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS%REACTOME DATABASE ID RELEASE 72%2151201 Transcriptional activation of mitochondrial biogenesis SIRT4 SIRT5 TFB2M PPRC1 POLRMT TBL1X SIRT3 POLG2 TFAM PERM1 TGS1 HELZ2 C10orf2 SOD2 GLUD1 CAMK4 SSBP1 TBL1XR1 GLUD2 SMARCD3 ACSS2 ATF2 NRF1 MEF2C CHD9 ATP5B CREB1 CARM1 MEF2D ALAS1 NR1D1 NCOA1 NCOA2 PPARGC1A CREBBP NCOA6 NCOR1 HDAC3 PPARGC1B RXRA PPARA IDH2 MED1 CYCS HCFC1 CRTC2 CRTC3 CRTC1 ESRRA TFB1M MTERF1 GABPA POTASSIUM CHANNELS%REACTOME DATABASE ID RELEASE 72%1296071 Potassium Channels KCNQ2 KCNQ3 KCNQ4 KCNQ5 KCNN1 KCNN2 KCNN3 KCNN4 KCNC1 KCNC3 KCNC4 KCNH2 KCNK10 KCNK13 KCNC2 KCNK16 KCNS3 KCNK17 ABCC8 KCNK18 KCNQ1 KCNA1 KCNA2 KCNA3 KCNA4 KCNA5 KCNA6 KCNA7 GABBR2 GABBR1 KCNMB1 KCNMA1 KCNB2 KCNMB2 KCNMB3 KCNMB4 KCNK6 KCNS1 KCNS2 KCNK7 KCNK9 KCNG1 KCNG3 KCNG4 KCNH1 KCNH3 KCNH4 KCND1 KCNH5 KCND2 KCNH6 KCND3 KCNH7 KCNH8 ABCC9 KCNB1 KCNG2 KCNV1 KCNV2 KCNF1 KCNJ2 KCNJ4 KCNJ12 KCNJ14 KCNK1 KCNK2 KCNK3 KCNK4 KCNJ11 KCNAB1 KCNAB2 KCNAB3 KCNA10 HCN4 HCN3 KCNJ8 GNG10 GNG12 GNG11 GNG13 KCNJ1 KCNJ3 GNB2 KCNJ5 KCNJ6 GNB1 KCNJ10 GNB4 KCNJ9 GNB3 KCNJ15 KCNJ16 GNB5 HCN2 HCN1 GNGT1 GNGT2 GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 SEROTONIN NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 72%181429 Serotonin Neurotransmitter Release Cycle SYN3 CPLX1 SYN1 RIMS1 BZRAP1 PPFIA1 PPFIA4 STX1A SLC18A2 VAMP2 PPFIA3 PPFIA2 UNC13B SNAP25 RAB3A SYT1 COOPERATION OF PDCL (PHLP1) AND TRIC CCT IN G-PROTEIN BETA FOLDING%REACTOME DATABASE ID RELEASE 72%6814122 Cooperation of PDCL (PhLP1) and TRiC CCT in G-protein beta folding GNG11 GNG13 GNAO1 CCT6A GNB2 GNB1 GNB4 PDCL GNB3 GNB5 GNGT1 GNGT2 CCT3 CCT2 TCP1 CSNK2A1 CCT6B CSNK2A2 GNAT2 GNAI3 GNAT3 GNAI1 GNAI2 GNG3 GNAT1 GNG2 RGS9 GNG5 RGS6 CSNK2B GNG4 RGS7 GNG7 GNG8 CCT8 CCT7 CCT5 CCT4 GNAZ RGS11 GNG10 GNG12 FGFR3C LIGAND BINDING AND ACTIVATION%REACTOME%R-HSA-190372.3 FGFR3c ligand binding and activation FGF9 FGF20 FGF16 FGF1 FGF2 FGF18 FGF23 GALNT3 FGF4 REGULATION OF GENE EXPRESSION IN ENDOCRINE-COMMITTED (NEUROG3+) PROGENITOR CELLS%REACTOME%R-HSA-210746.1 Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells INSM1 NEUROD1 NEUROG3 NKX2-2 PAX4 CARBOXYTERMINAL POST-TRANSLATIONAL MODIFICATIONS OF TUBULIN%REACTOME DATABASE ID RELEASE 72%8955332 Carboxyterminal post-translational modifications of tubulin AGBL5 AGBL4 AGBL1 AGBL3 AGBL2 TUBA1C TUBA1B TUBA1A TUBB8P12 TUBB8 TUBB2B TUBB2A LRRC49 TUBB6 TTLL7 TUBB3 TTLL6 TTLL5 TUBB1 TTLL4 TTL TTLL3 TTLL2 TUBA3E TTLL1 TPGS1 TTLL9 TTLL8 TPGS2 AGTPBP1 TUBB4B TUBB4A TTLL10 NICN1 TTLL11 TTLL12 BETA-OXIDATION OF PRISTANOYL-COA%REACTOME DATABASE ID RELEASE 72%389887 Beta-oxidation of pristanoyl-CoA ACOT8 CROT ACOX2 AMACR ACOX3 ACOXL HSD17B4 CRAT LECTIN PATHWAY OF COMPLEMENT ACTIVATION%REACTOME%R-HSA-166662.3 Lectin pathway of complement activation COLEC11 FCN1 FCN2 FCN3 COLEC10 MASP1 MBL2 G ALPHA (Q) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 72%416476 G alpha (q) signalling events QRFPR HTR2B CCK XCL2 HTR2C XCL1 GRPR HTR2A PROK2 PROK1 GNA14 TRHR RASGRP2 GNA15 APP RASGRP1 GNA11 CYSLTR1 GPR132 GAST GPR4 GPR143 XCR1 DGKG DGKE CHRM1 DGKD PLCB3 DGKB PLCB4 DGKA CHRM5 PLCB1 MCHR1 PLCB2 ABHD12 DGKZ DGKQ DGKK DGKI DGKH ABHD6 GCG DAGLA TRH DAGLB OXTR AVP EDNRA EDNRB UTS2R UTS2B PTGFR ANXA1 AGT NTSR1 NTSR2 NMB NMBR NMS NMU CHRM3 QRFP BRS3 CCKAR GPR39 FFAR3 FFAR2 EDN1 EDN2 EDN3 AVPR1B AVPR1A CCKBR PTGER1 HRAS KISS1R F2RL1 F2RL2 F2RL3 MGLL NPSR1 PMCH NRAS HBEGF GHSR GNAQ NTS NPS OPN4 P2RY11 NMUR2 NMUR1 MLNR GRK5 BDKRB2 BDKRB1 RGS18 RGS13 RGS21 KISS1 KNG1 PRKCQ HRH1 F2R F2 GNG10 FPR2 GNG12 GNG11 GNG13 GNB2 GNB1 GNB4 GNB3 GNB5 GNGT1 PIK3R1 GNGT2 EGFR PIK3CA SOS1 GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 FFAR1 AGTR1 TACR2 TACR3 TAC3 TACR1 CYSLTR2 TAC1 PIK3R3 FFAR4 GPR17 LTB4R2 LTB4R MMP3 GRP P2RY1 SAA1 PRKCE PTAFR TRPC7 TRPC6 TRPC3 PRKCD PRKCA P2RY10 LPAR4 P2RY6 LPAR6 P2RY2 ITPR1 ITPR2 ITPR3 PIK3R2 GRM1 GRM5 RPS6KA3 ADRBK1 RPS6KA2 ADRA1D RPS6KA1 ADRA1B ADRA1A HCRT GPRC6A CREB1 PROKR1 PROKR2 GPR68 GPR65 MAPK7 UTS2 MAPK1 MAPK3 HCRTR2 HCRTR1 NPFFR2 NPFFR1 NPFF LPAR1 LPAR2 LPAR3 LPAR5 TBXA2R GNRH2 GNRH1 MLN GNRHR TRIO RGS17 RGS19 RGSL1 RGS16 RGS4 RGS5 PRKCH RGS2 RGS3 RGS1 CASR ARHGEF25 MCHR2 BTK OXT KALRN TFAP2 (AP-2) FAMILY REGULATES TRANSCRIPTION OF GROWTH FACTORS AND THEIR RECEPTORS%REACTOME DATABASE ID RELEASE 72%8866910 TFAP2 (AP-2) family regulates transcription of growth factors and their receptors KIT TFAP2A CGA TFAP2C EGFR VEGFA ATAD2 ERBB2 TGFA YY1 ESR1 TFAP2B LXRS REGULATE GENE EXPRESSION LINKED TO LIPOGENESIS%REACTOME DATABASE ID RELEASE 72%9029558 LXRs regulate gene expression linked to lipogenesis ANGPTL3 NR1H2 RXRB RXRA FASN NRIP1 NR1H3 SCD SCAVENGING BY CLASS B RECEPTORS%REACTOME DATABASE ID RELEASE 72%3000471 Scavenging by Class B Receptors APOA1 CD36 APOB SAA1 SSC5D CITRIC ACID CYCLE (TCA CYCLE)%REACTOME%R-HSA-71403.2 Citric acid cycle (TCA cycle) SUCLG2 SUCLG1 SUCLA2 CS IDH3B IDH2 NNT DLD IDH3A FH ME3 IDH3G MDH2 ME2 SDHC FAHD1 SDHD SDHA DLST SDHB ACO2 OGDH SIGNALLING TO RAS%REACTOME DATABASE ID RELEASE 72%167044 Signalling to RAS RALA HRAS MAPK14 RALGDS MAPK11 MAPKAPK3 RALB MAPK12 MAPK13 SHC2 NRAS SHC1 MAPKAPK2 SOS1 NTRK1 SHC3 NGF DISSOLUTION OF FIBRIN CLOT%REACTOME%R-HSA-75205.2 Dissolution of Fibrin Clot PLG PLAUR ANXA2 SERPINF2 SERPINE1 SERPINE2 SERPINB6 PLAT SERPINB2 SERPINB8 PLAU S100A10 HRG CD28 DEPENDENT PI3K AKT SIGNALING%REACTOME DATABASE ID RELEASE 72%389357 CD28 dependent PI3K Akt signaling PDPK1 CD80 CD28 AKT1 MAP3K8 MTOR PIK3R3 PRR5 TRIB3 THEM4 MAPKAP1 PIK3R1 PIK3R2 PIK3CA AKT2 AKT3 MAP3K14 MLST8 RICTOR FYN CD86 LCK VASOPRESSIN REGULATES RENAL WATER HOMEOSTASIS VIA AQUAPORINS%REACTOME%R-HSA-432040.2 Vasopressin regulates renal water homeostasis via Aquaporins GNG11 GNG13 PRKAR2B PRKAR2A GNB2 AQP4 AVP GNB1 AQP2 GNB4 AQP3 AQP1 GNB3 GNAS GNB5 GNGT1 GNGT2 ADCY4 ADCY3 PRKACG ADCY2 AVPR2 ADCY1 PRKACA ADCY8 PRKACB ADCY7 ADCY6 ADCY5 GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 RAB11FIP2 MYO5B RAB11A GNG10 ADCY9 PRKAR1B PRKAR1A GNG12 SIGNALING BY ERYTHROPOIETIN%REACTOME DATABASE ID RELEASE 72%9006335 Signaling by Erythropoietin EPO RAPGEF1 LYN HRAS VAV1 STAT5A CRKL PLCG2 STAT5B PIK3CD NRAS PIK3CG PIK3R5 IRS2 EPOR SHC1 GAB1 JAK2 PIK3R1 PIK3CB PIK3CA PLCG1 SOS1 NEGATIVE REGULATION OF MET ACTIVITY%REACTOME%R-HSA-6807004.1 Negative regulation of MET activity SH3GL1 SH3GL2 HGF MET UBB PTPN2 STAM UBC PTPN1 CBL RPS27A UBA52 HGS PTPRJ SH3GL3 SH3KBP1 STAM2 USP8 LRIG1 EPS15 PKB-MEDIATED EVENTS%REACTOME%R-HSA-109703.4 PKB-mediated events AKT2 PDE3B DEFECTIVE ACTH CAUSES OBESITY AND PRO-OPIOMELANOCORTININ DEFICIENCY (POMCD)%REACTOME%R-HSA-5579031.3 Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) POMC MC2R VIRAL RNP COMPLEXES IN THE HOST CELL NUCLEUS%REACTOME DATABASE ID RELEASE 72%168330 Viral RNP Complexes in the Host Cell Nucleus IONOTROPIC ACTIVITY OF KAINATE RECEPTORS%REACTOME%R-HSA-451306.2 Ionotropic activity of kainate receptors DLG1 DLG4 GRIK5 DLG3 GRIK3 GRIK4 GRIK1 GRIK2 NCALD METALLOPROTEASE DUBS%REACTOME%R-HSA-5689901.2 Metalloprotease DUBs HIST2H2AB HIST2H2AA3 STAM HIST2H2AA4 HIST2H2AC STAMBPL1 UBA52 BRCC3 HIST1H2AE NLRP3 HIST1H2AD STAMBP HIST1H2AC BARD1 FAM175B PSMD14 MYSM1 HIST1H2AB HIST1H2AJ EP300 HIST3H2A KAT2B BRE UBB BABAM1 UIMC1 UBC HIST1H2AG HIST1H2AA RPS27A HIST1H2AM HIST1H2AL HIST1H2AI FAM175A BRCA1 HIST1H2AH HIST1H2AK CHAPERONE MEDIATED AUTOPHAGY%REACTOME DATABASE ID RELEASE 72%9613829 Chaperone Mediated Autophagy PLIN3 PCNT RNASE1 PLIN2 PARK7 HDAC6 HSP90AB1 LAMP2 GFAP UBB CETN1 UBC HBB CFTR RPS27A UBA52 HSPA8 HSP90AA1 IFT88 EEF1A1 ARL13B TRAF6 MEDIATED NF-KB ACTIVATION%REACTOME%R-HSA-933542.1 TRAF6 mediated NF-kB activation HMGB1 IKBKB NKIRAS1 IFIH1 NKIRAS2 RNF135 CHUK MAVS TRIM25 NFKB1 NFKB2 AGER DDX58 S100A12 TRAF2 MAP3K1 TRAF6 APP S100B NFKBIA SAA1 IKBKG RELA NFKBIB RUNX2 REGULATES BONE DEVELOPMENT%REACTOME%R-HSA-8941326.1 RUNX2 regulates bone development YES1 HES1 BGLAP ZNF521 CBFB GLI3 GLI2 SATB2 COL1A1 WWTR1 RBM14 IHH HDAC3 HEY1 HEY2 HDAC4 AR SP7 SMAD4 ABL1 HDAC6 YAP1 SMAD1 SMAD6 RB1 SRC MAPK1 MAF UCMA MAPK3 HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME DATABASE ID RELEASE 72%5693579 Homologous DNA Pairing and Strand Exchange EXO1 HUS1 RPA1 RPA2 TOPBP1 WRN RPA3 RMI2 RFC5 DNA2 RFC3 RMI1 RFC4 TOP3A RHNO1 RFC2 RAD51D BRIP1 ATRIP BARD1 XRCC2 XRCC3 MRE11A RAD51AP1 RAD51 RBBP8 RAD17 ATM BRCA2 RAD1 PALB2 ATR RAD9B RAD9A RAD51B KAT5 RAD50 CHEK1 RAD51C BRCA1 NBN BLM HSF1-DEPENDENT TRANSACTIVATION%REACTOME%R-HSA-3371571.1 HSF1-dependent transactivation CAMK2D CAMK2A AKT1S1 HSPA2 EP300 MTOR HSP90AB1 HSPB8 CAMK2G PTGES3 HSBP1 HSF1 CRYAB HSPA8 MLST8 HSP90AA1 FKBP4 DNAJB1 CAMK2B CREBBP HSPA1L RPTOR RNA POLYMERASE II PROMOTER ESCAPE%REACTOME%R-HSA-73776.3 RNA Polymerase II Promoter Escape GTF2F1 TAF2 GTF2B GTF2F2 CDK7 GTF2A1 POLR2A GTF2A2 POLR2B TAF1 POLR2C GTF2E1 POLR2D GTF2E2 POLR2G POLR2E MNAT1 POLR2F POLR2H POLR2I POLR2J AK6 POLR2K CCNH POLR2L GTF2H1 GTF2H2 GTF2H3 GTF2H4 TAF9B GTF2H5 TBP ERCC3 ERCC2 TAF9 TAF1L TAF15 TAF12 TAF13 TAF4B TAF10 TAF11 TAF7 TAF6 TAF5 TAF7L TAF4 TAF3 MRNA DECAY BY 5' TO 3' EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 72%430039 mRNA decay by 5' to 3' exoribonuclease LSM1 LSM2 DDX6 DCP1A PATL1 LSM7 LSM6 DCP1B XRN1 DCP2 EDC3 EDC4 LSM5 LSM4 LSM3 MITOCHONDRIAL TRANSLATION%REACTOME%R-HSA-5368287.1 Mitochondrial translation MRPL39 MRPL36 MRPL37 MRPL34 MRPL35 MRPL32 MRPL33 MRPL4 MRPL41 MRPL3 MRPL42 MRPL2 MRPL1 MRPL40 MRPL9 CHCHD1 MRPS28 TSFM MRPS26 MRPS27 MRPS24 MRPS25 MRPS22 MRPS23 MRPL49 MRPS18B MRPS2 MRPS18A MRPL47 MRPL48 MRPL45 MRPS7 MRPL46 MRPS6 MRPS5 MRPL43 MRPS18C TUFM MRPL44 MRPL52 OXA1L MRPL53 MRPL50 MRPS9 MRPL51 AURKAIP1 DAP3 MRPS35 MRPS36 MRPL18 MRPS33 MRPL19 MRPS34 MRPL16 MRPS31 MRPL17 MRPL14 MRPL15 MRPS30 MRPL12 MRPL57 MRPL13 MRPL10 MRPL54 MRPL55 MRPL11 MRPL20 ICT1 GADD45GIP1 PTCD3 MRPL27 MRPL28 ERAL1 MRPL23 MRPL24 MRPL21 MRPL22 MRPL30 GFM2 MRRF MTFMT MRPS17 MRPS15 GFM1 MRPS16 MTRF1L MRPS14 MTIF2 MRPS11 MTIF3 MRPS12 MRPL38 MRPS10 BIOSYNTHESIS OF EPA-DERIVED SPMS%REACTOME%R-HSA-9018679.1 Biosynthesis of EPA-derived SPMs PTGS2 ALOX15 LTA4H HPGD ALOX5 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS)%REACTOME%R-HSA-70221.3 Glycogen breakdown (glycogenolysis) PHKB PHKG1 PHKG2 AGL PGM2 PGM2L1 GAA PYGB PHKA1 PHKA2 PYGM PYGL GYG2 GYG1 ACYL CHAIN REMODELLING OF PE%REACTOME DATABASE ID RELEASE 72%1482839 Acyl chain remodelling of PE MBOAT2 LPCAT4 RARRES3 LPCAT3 PLA2G12A PLA2G4F PLA2G4D PLA2G4B PLA2G4C PLA2G4A HRASLS2 PLA2G16 PLA2G10 PLA2G1B PLBD1 HRASLS5 PLA2R1 ABHD4 PLA2G3 PLA2G2F PLA2G5 PLA2G2D PLA2G2E PLA2G6 PNPLA8 PLA2G2A MBOAT1 CREATION OF C4 AND C2 ACTIVATORS%REACTOME%R-HSA-166786.2 Creation of C4 and C2 activators IGHG1 C1QB IGHG2 IGKV3-11 C1QA IGKV1-12 C1S C1R COLEC11 CRP FCN2 FCN3 COLEC10 MASP1 IGKV2D-28 MBL2 IGKV4-1 IGKV2-28 IGKV2D-30 IGKV5-2 FCN1 C1QC IGKV3D-20 IGHG4 RPIA DEFICIENCY: FAILED CONVERSION OF RU5P TO R5P%REACTOME%R-HSA-6791461.2 RPIA deficiency: failed conversion of RU5P to R5P RPIA MOLECULES ASSOCIATED WITH ELASTIC FIBRES%REACTOME DATABASE ID RELEASE 72%2129379 Molecules associated with elastic fibres ITGB5 MFAP5 MFAP4 EFEMP2 MFAP1 EFEMP1 MFAP3 MFAP2 LTBP4 LTBP2 FBLN1 LTBP3 LTBP1 TGFB1 FBLN2 FBLN5 GDF5 TGFB2 TGFB3 BMP7 VTN BMP4 BMP2 ITGB3 ITGB1 BMP10 ITGB8 ITGB6 ITGAV ITGA8 ENZYMATIC DEGRADATION OF DOPAMINE BY COMT%REACTOME DATABASE ID RELEASE 72%379397 Enzymatic degradation of dopamine by COMT MAOA LRTOMT COMT ARMS-MEDIATED ACTIVATION%REACTOME%R-HSA-170984.3 ARMS-mediated activation YWHAB BRAF NTRK1 RAP1A KIDINS220 CRK NGF KERATINIZATION%REACTOME%R-HSA-6805567.2 Keratinization KRTAP24-1 KRT6C KRT6B KRT6A KRT71 KRTAP13-2 KRTAP13-1 KRTAP13-4 KRTAP13-3 KRT79 KRT78 KRT77 KRT76 KRT75 KRT74 KRT73 KRT72 KRT40 KRTAP22-1 KRTAP11-1 KRT82 KRT81 KRT80 KRT86 KRT85 KRT84 KRT83 CAPNS1 CAPN1 FURIN PCSK6 DSP DSG1 PKP1 DSG2 DSG3 PI3 DSC1 KRT1 TCHH LCE1A TGM1 CASP14 LCE1B LCE5A LIPJ LIPN LIPM LIPK PRSS8 TGM5 RPTN CELA2A KRTAP27-1 SPINK6 KRTAP5-10 SPINK5 KRTAP5-11 KAZN LCE1E KRTAP16-1 LCE1F KRTAP25-1 LOR LCE1C KRTAP2-4 LCE1D KRTAP2-3 LCE2B LCE2C KRTAP2-2 LCE2A KRTAP2-1 LCE6A PKP2 KRTAP4-4 PKP4 KRTAP4-3 SPINK9 PKP3 KRTAP4-2 KRTAP4-1 DSG4 IVL KRTAP4-9 DSC2 KRTAP4-8 DSC3 KRTAP4-7 FLG KRTAP4-6 SPRR2E KRTAP4-5 SPRR2F PERP SPRR3 SPRR2G KRTAP29-1 CSTA KRTAP6-2 KLK5 KRTAP6-1 KLK8 KRTAP6-3 EVPL KRTAP8-1 LCE2D LCE3C LCE3D LCE3A KRTAP23-1 LCE3B LELP1 KRTAP12-1 SPRR2A KRTAP12-3 SPRR2B KRTAP12-2 SPRR2D JUP KRTAP12-4 ST14 KRTAP10-1 CDSN KRTAP21-2 KLK13 KRTAP21-3 KLK14 LCE3E KRTAP10-3 KLK12 KRTAP10-2 LCE4A KRTAP10-5 SPRR1A KRTAP10-4 SPRR1B KRTAP10-7 KRTAP10-6 KRTAP10-9 KRTAP10-8 KRTAP21-1 KRTAP17-1 KRTAP4-11 KRTAP26-1 KRTAP1-5 KRTAP1-4 KRTAP1-3 KRTAP1-1 KRTAP15-1 KRTAP3-3 KRTAP3-2 KRTAP3-1 KRTAP5-3 KRTAP5-2 KRTAP5-1 KRTAP5-9 KRTAP5-8 KRTAP5-7 KRTAP5-6 KRTAP5-5 KRTAP5-4 KRTAP19-2 KRTAP19-1 KRTAP19-4 KRTAP19-3 KRTAP19-6 KRTAP19-5 KRTAP19-8 KRTAP19-7 KRT4 KRT3 KRT2 KRT8 KRT7 KRT5 KRT9 KRTAP20-1 KRTAP20-2 KRTAP10-10 KRTAP10-11 KRTAP10-12 KRT33B KRT33A KRT24 KRT23 KRT20 KRT28 KRT27 KRT26 PPL KRT25 KRTAP9-7 KRTAP9-6 KRTAP9-4 KRTAP9-3 KRTAP9-2 KRTAP9-1 KRT35 KRT34 KRT32 KRT31 KRTAP9-9 KRTAP9-8 KRT39 KRT38 KRT37 KRT36 KRT13 KRT12 KRT10 KRT19 KRT18 KRT17 KRT16 KRT15 KRT14 HS-GAG BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 72%2022928 HS-GAG biosynthesis SDC4 SDC2 HS2ST1 SDC3 HS3ST3A1 NDST2 NDST1 SLC35D2 NDST4 NDST3 EXT1 EXT2 HS3ST5 HS3ST6 HS3ST4 SDC1 HS3ST1 HS3ST2 HS6ST1 HS6ST2 HS6ST3 GPC1 GPC3 GPC2 GPC5 GPC4 GPC6 GLCE HSPG2 HS3ST3B1 AGRN PI5P REGULATES TP53 ACETYLATION%REACTOME DATABASE ID RELEASE 72%6811555 PI5P Regulates TP53 Acetylation PIN1 ING2 EP300 MAP2K6 PIP4K2A TMEM55B PIP4K2B PIP4K2C TP53 APOPTOSIS INDUCED DNA FRAGMENTATION%REACTOME DATABASE ID RELEASE 72%140342 Apoptosis induced DNA fragmentation HMGB1 H1F0 HMGB2 KPNA1 CASP3 HIST1H1D HIST1H1E KPNB1 HIST1H1A HIST1H1B HIST1H1C DFFB DFFA MODULATION BY MTB OF HOST IMMUNE SYSTEM%REACTOME%R-HSA-9637628.1 Modulation by Mtb of host immune system UBC B2M RPS27A UBA52 MRC1 UBB TLR2 SIGNALLING TO P38 VIA RIT AND RIN%REACTOME%R-HSA-187706.2 Signalling to p38 via RIT and RIN BRAF NTRK1 RIT1 RIT2 NGF PTK6 DOWN-REGULATION%REACTOME DATABASE ID RELEASE 72%8849472 PTK6 Down-Regulation PTPN1 SRMS PTK6 RHO GTPASES ACTIVATE FORMINS%REACTOME%R-HSA-5663220.1 RHO GTPases Activate Formins PPP1CC NUP107 PPP2R5C ERCC6L ZWILCH BUB1B CASC5 CDC20 PPP2R1B PPP2R1A KNTC1 DAAM1 DYNC1LI1 PFN1 BIRC5 DYNC1LI2 CLIP1 ZW10 MAD1L1 CDCA8 SEC13 PMF1 NUP133 SKA1 AURKB SKA2 DSN1 PPP2R5D RCC2 NDC80 ZWINT KIF18A SGOL2 SGOL1 NUF2 SPDL1 NDEL1 NUDC MKL1 DYNLL2 KIF2A INCENP KIF2C KIF2B ITGB3BP DIAPH1 MIS12 CENPA NSL1 NUP160 CENPC PPP2CA BUB3 PPP2CB BUB1 NUP85 DYNC1I1 CLASP2 CENPT CENPU NUP43 CENPE CENPF CENPH CENPI TAOK1 RANBP2 CENPK CENPL CENPM CENPN B9D2 CENPO CENPP CENPQ SPC24 MAD2L1 SPC25 NUP37 DYNLL1 CKAP5 MAPRE1 PAFAH1B1 PFN2 XPO1 DYNC1I2 SCAI RAC1 PPP2R5E PPP2R5B PPP2R5A DIAPH3 CLASP1 DYNC1H1 NDE1 FMNL3 FMNL1 FMNL2 RHOC RHOD RHOB ACTG1 ACTB CDC42 DVL1 DVL3 RPS27 DVL2 PLK1 SRF EVL APITD1 AHCTF1 RANGAP1 RHOA ITGB1 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+%REACTOME%R-HSA-76005.2 Response to elevated platelet cytosolic Ca2+ ECM1 OLA1 CTSW SERPINA4 TMSB4X TIMP3 ANXA5 TOR4A LY6G6F LHFPL2 PCYOX1L FAM49B FAM3C SOD1 TMX3 TIMP1 RARRES2 PRKCG SCCPDH LGALS3BP WDR1 ACTN2 PLEK PHACTR2 SRGN MMRN1 ITIH4 ITIH3 CLEC3B APP PFN1 CDC37L1 PCDH7 SPARC SPP2 STXBP2 PPBP ORM1 SERPINE1 ALDOA ORM2 SELP APOA1 CD109 QSOX1 STX4 CAP1 RAB27B CALU CD63 PPIA IGF1 TF CD36 CLU TGFB2 TGFB3 ITGB3 CFD FIGF PSAP VEGFB VEGFC PRKCB ALB PLG PDGFB IGF2 CFL1 PRKCA ITGA2B APOOL GAS6 PROS1 F13A1 KNG1 VCL A2M FGB FGA FN1 VWF HGF STXBP3 FGG F5 LEFTY2 F8 TUBA4A SERPING1 HSPA5 PF4 A1BG CYB5R1 FLNA SERPINA3 ACTN1 SERPINA1 ABCC4 EGF AHSG TTN BRPF3 THBS1 TGFB1 APLP2 SCG3 LAMP2 ISLR HABP4 CHID1 SERPINF2 GTPBP2 SYTL4 SEPP1 TAGLN2 NHLRC2 TEX264 VEGFA CD9 ENDOD1 APOH VTI1B MANF MAGED2 TLN1 HRG ACTN4 FERMT3 RETINOID METABOLISM AND TRANSPORT%REACTOME%R-HSA-975634.2 Retinoid metabolism and transport SDC4 SDC2 SDC3 TTR APOM RETSAT BCO2 APOE BCO1 APOB APOC3 PLB1 APOC2 SDC1 AKR1B10 PNLIP GPIHBP1 LRP1 RDH11 LPL GPC1 GPC3 GPC2 LRAT GPC5 LRP2 GPC4 GPC6 LDLR LRP8 HSPG2 AKR1C1 APOA2 APOA1 AKR1C3 APOA4 RBP4 LRP10 RBP2 LRP12 AKR1C4 CLPS RBP1 AGRN CIRCADIAN CLOCK%REACTOME DATABASE ID RELEASE 72%400253 Circadian Clock CUL1 ARNTL TBL1X PPP1CC TGS1 HELZ2 UBA52 TBL1XR1 SMARCD3 ATF2 CLOCK EP300 NPAS2 NAMPT MEF2C NRIP1 CHD9 RORA UBB F7 UBC SERPINE1 CREB1 RPS27A CARM1 MEF2D NR3C1 AVP NR1D1 FBXL3 HIF1A PPP1CB NCOA1 NCOA2 PPARGC1A CREBBP NCOA6 NCOR1 HDAC3 SIRT1 RXRA CSNK1D PPARA BHLHE41 CSNK1E RBM4 DBP CCRN4L MED1 KLF15 CRY2 CRY1 SIK1 SREBF1 ARNTL2 BTRC RAI1 SKP1 NFIL3 CRTC2 PER2 CRTC3 PER1 CRTC1 BHLHE40 CPT1A PPP1CA TRANSLESION SYNTHESIS BY POLK%REACTOME DATABASE ID RELEASE 72%5655862 Translesion synthesis by POLK RPA1 POLK RPA2 RFC1 MAD2L2 RPA3 RFC5 REV1 RFC3 RFC4 UBB RFC2 REV3L UBC RPS27A UBA52 PCNA FCGR ACTIVATION%REACTOME DATABASE ID RELEASE 72%2029481 FCGR activation IGHG1 IGHG2 IGKV3-11 HCK IGKV1-12 LYN YES1 FGR IGKV2D-28 IGKV4-1 CD3G FCGR3A IGKV2-28 IGKV2D-30 FCGR1A SYK IGKV5-2 FCGR2A FYN IGKV3D-20 IGHG4 EPHB-MEDIATED FORWARD SIGNALING%REACTOME%R-HSA-3928662.2 EPHB-mediated forward signaling SDC2 LYN CFL1 YES1 LIMK2 LIMK1 ARPC1B ROCK1 ARPC1A WASL ROCK2 ACTG1 ACTB CDC42 PAK1 TIAM1 ARPC4 ARPC5 ARHGEF28 FYN ARPC2 ARPC3 ACTR3 ACTR2 HRAS RASA1 GRIN2B PTK2 ITSN1 GRIN1 RHOA KALRN RAC1 CONDENSATION OF PROMETAPHASE CHROMOSOMES%REACTOME DATABASE ID RELEASE 72%2514853 Condensation of Prometaphase Chromosomes CDK1 CSNK2A2 SMC4 SMC2 NCAPG NCAPH CCNB1 CSNK2B CCNB2 CSNK2A1 NCAPD2 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX%REACTOME DATABASE ID RELEASE 72%141430 Inactivation of APC C via direct inhibition of the APC C complex BUB3 ANAPC15 ANAPC16 ANAPC7 UBE2C UBE2E1 UBE2D1 ANAPC10 ANAPC11 CDC23 CDC26 CDC27 CDC16 ANAPC4 BUB1B ANAPC5 ANAPC1 MAD2L1 ANAPC2 CDC20 NGF-INDEPENDANT TRKA ACTIVATION%REACTOME DATABASE ID RELEASE 72%187024 NGF-independant TRKA activation ADCYAP1R1 ADORA2A NTRK2 NTRK1 ADCYAP1 PKMTS METHYLATE HISTONE LYSINES%REACTOME DATABASE ID RELEASE 72%3214841 PKMTs methylate histone lysines WHSC1 RBBP4 SUV39H2 SETD2 SETD3 SETD6 SETD7 ASH2L RBBP7 MECOM EHMT2 SUZ12 ASH1L DOT1L RELA NSD1 HIST2H3A HIST2H3D PRDM9 HIST2H3C HIST1H3J HIST1H3A HIST1H3F HIST1H3G HIST1H3H EHMT1 HIST1H3I WHSC1L1 HIST1H3B HIST1H3C HIST1H3D HIST1H3E HIST1H4K HIST1H4L HIST1H4A HIST1H4B KMT2E HIST1H4H KMT2D HIST1H4I HIST1H4J KMT2A HIST1H4C KMT2C KMT2B HIST1H4D HIST1H4E EZH2 HIST1H4F SMYD2 SMYD3 SUV39H1 NFKB1 NFKB2 EED DPY30 WDR5 SUV420H2 SUV420H1 AEBP2 HIST4H4 RBBP5 ATF7IP SETD8 PRDM16 SETDB1 SETD1B HIST2H4A SETD1A SETDB2 HIST2H4B ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING%REACTOME%R-HSA-451326.2 Activation of kainate receptors upon glutamate binding GNG11 GNG13 GNB2 GNB1 GNB4 GNB3 GNB5 GNGT1 DLG1 DLG4 GNGT2 DLG3 GNG3 GNG2 PLCB3 GNG5 GNG4 GNG7 GNG8 PLCB1 PLCB2 GRIK5 GRIK3 GRIK4 GRIK1 GRIK2 NCALD GNG10 GNG12 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS%REACTOME DATABASE ID RELEASE 72%1296041 Activation of G protein gated Potassium channels GNG11 GNG13 KCNJ3 KCNJ5 GNB2 KCNJ6 KCNJ10 GNB1 GNB4 KCNJ2 KCNJ9 KCNJ15 GNB3 KCNJ4 KCNJ16 KCNJ12 GNB5 GNGT1 GNGT2 GABBR2 GABBR1 GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 GNG10 GNG12 DEFECTIVE SLC4A1 CAUSES HEREDITARY SPHEROCYTOSIS TYPE 4 (HSP4), DISTAL RENAL TUBULAR ACIDOSIS (DRTA) AND DRTA WITH HEMOLYTIC ANEMIA (DRTA-HA)%REACTOME DATABASE ID RELEASE 72%5619050 Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA) SLC4A1 TRANSLOCATION OF SLC2A4 (GLUT4) TO THE PLASMA MEMBRANE%REACTOME%R-HSA-1445148.2 Translocation of SLC2A4 (GLUT4) to the plasma membrane AKT1 KIF3A YWHAG YWHAZ YWHAH VAMP2 RAB10 RHOQ SNAP23 RAB4A PRKAA2 RALA MYO1C STXBP3 EXOC8 EXOC7 SLC2A4 RAB11A RAB13 STX4 RALGAPA2 EXOC4 RALGAPB EXOC3 EXOC6 EXOC5 EXOC2 EXOC1 PRKAB2 PRKAB1 LNPEP C2CD5 ASPSCR1 KIFAP3 TBC1D1 TBC1D4 MYO5A RAB14 KIF3B SFN RAB8A MYH9 YWHAB YWHAE AKT2 PRKAG1 PRKAG2 PRKAG3 RAC1 YWHAQ DEFECTIVE POMT1 CAUSES MDDGA1, MDDGB1 AND MDDGC1%REACTOME%R-HSA-5083633.1 Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1 POMT1 POMT2 DAG1 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA%REACTOME%R-HSA-3359485.1 Defective CD320 causes methylmalonic aciduria CD320 TCN2 DEFECTIVE SLC34A1 CAUSES HYPOPHOSPHATEMIC NEPHROLITHIASIS OSTEOPOROSIS 1 (NPHLOP1)%REACTOME%R-HSA-5619040.1 Defective SLC34A1 causes hypophosphatemic nephrolithiasis osteoporosis 1 (NPHLOP1) SLC34A1 SYNTHESIS OF HEPOXILINS (HX) AND TRIOXILINS (TRX)%REACTOME DATABASE ID RELEASE 72%2142696 Synthesis of Hepoxilins (HX) and Trioxilins (TrX) ALOX12 TIGHT JUNCTION INTERACTIONS%REACTOME%R-HSA-420029.1 Tight junction interactions CRB3 CLDN2 CLDN1 CLDN22 CLDN20 CLDN23 CLDN11 CLDN5 CLDN6 CLDN10 CLDN4 CLDN3 CLDN15 CLDN14 F11R CLDN9 CLDN8 CLDN12 CLDN7 PARD6A PRKCI CLDN19 PARD3 CLDN18 CLDN17 CLDN16 PARD6G PARD6B MPP5 INADL FORMATION OF APOPTOSOME%REACTOME%R-HSA-111458.3 Formation of apoptosome APIP CARD8 CASP9 AVEN MAPK1 APAF1 DIABLO XIAP UACA MAPK3 CYCS ADENOSINE P1 RECEPTORS%REACTOME%R-HSA-417973.1 Adenosine P1 receptors ADORA2A ADORA2B ADORA3 ADORA1 CALNEXIN CALRETICULIN CYCLE%REACTOME%R-HSA-901042.2 Calnexin calreticulin cycle RNF139 OS9 UGGT2 UGGT1 PDIA3 EDEM3 EDEM1 AMFR EDEM2 SYVN1 MARCH6 RNF103 CANX TRIM13 CALR MAN1B1 RNF185 UBA52 UBB UBC RPS27A PRKCSH SEL1L DERL2 RNF5 GANAB BIOSYNTHESIS OF ELECTROPHILIC Ω-3 PUFA OXO-DERIVATIVES%REACTOME DATABASE ID RELEASE 72%9027604 Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives PTGS2 ALOX5 TWIK-RELATED SPINAL CORD K+ CHANNEL (TRESK)%REACTOME%R-HSA-1299344.1 TWIK-related spinal cord K+ channel (TRESK) KCNK18 TRANSCRIPTION-COUPLED NUCLEOTIDE EXCISION REPAIR (TC-NER)%REACTOME%R-HSA-6781827.1 Transcription-Coupled Nucleotide Excision Repair (TC-NER) LIG1 POLK RPA1 POLE RPA2 POLD3 RFC1 POLD4 RPA3 AQR POLD1 POLR2E POLD2 POLR2F RFC5 POLR2H RFC3 RFC4 RFC2 ZNF830 POLR2K CCNH POLR2L XPA COPS7B UBA52 COPS7A GTF2H1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 ERCC3 ERCC2 ERCC6 XRCC1 EP300 CUL4A POLE4 ERCC4 ERCC1 TCEA1 POLE2 PRPF19 UBB POLE3 ERCC8 ERCC5 UBC CUL4B RPS27A DDB1 GPS1 USP7 CDK7 POLR2A POLR2B POLR2C POLR2D XAB2 POLR2G MNAT1 POLR2I POLR2J HMGN1 LIG3 PPIE COPS4 COPS3 ELL COPS6 COPS5 COPS2 UVSSA RBX1 COPS8 ISY1 PCNA IGF1R SIGNALING CASCADE%REACTOME DATABASE ID RELEASE 72%2428924 IGF1R signaling cascade PDPK1 IGF2 FRS2 PTPN11 FGF16 TRIB3 FGF7 FGF18 TLR9 GAB1 IGF1 PIK3R1 PIK3R2 FGF6 PIK3CA FGF9 SOS1 FGF20 FGF1 FGF2 FGF23 FGF3 FGF22 PIK3C3 FGF10 FGF4 HRAS PIK3R4 IGF1R KLB IRS4 IRS1 FLT3 NRAS PDE3B IRS2 THEM4 FLT3LG GAB2 FGF19 PIK3CB FGFR4 AKT2 INNATE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 72%168249 Innate Immune System CUL1 IQGAP2 CAPZA1 CAPZA2 RAB18 ACTR10 PDXK UBE2K ITCH IRAK3 TIRAP TLR1 SIGIRR UNC93B1 CTSV TLR6 CNPY3 TLR2 CTSS CTSL CTSK CTSB PPP3R1 LCK SLCO4C1 BCL2L1 BCL2 PPIA IQGAP1 TLR10 TLR5 CYB5R3 HRAS NRAS HEXB CFD C3 ECSIT GZMM CFB ARG1 FABP5 PRDX6 KPNB1 PGLYRP4 PGLYRP3 PGLYRP2 LEAP2 HTN1 S100A7A HTN3 BPIFA1 GNLY BPIFA2 EPPIN HSP90AB1 DCD RNASE6 REG3A ITLN1 REG3G EPPIN-WFDC6 ART1 RNASE8 RNASE7 PI3 PIK3R1 CHGA DEFA6 DEFA5 NDUFC2 DEFA3 PIK3CA BPIFB2 PLCG1 BPIFB1 SOS1 BPIFB4 OTUD5 DHX58 BPIFB6 SEMG1 ATG12 RNF125 NLRX1 PIK3C3 NLRC5 RNF216 APEH ATOX1 PCBP2 ATG5 PPP3CA PPP3CB NFATC3 NFATC1 CRP RHOA PADI2 IFNB1 LY86 FCER1A MS4A2 CLEC10A TXK LPO EEA1 RBSN HSPA6 TIFA ALPK1 LAT2 PPAPDC1A PPAPDC1B COLEC11 CD180 CLEC4A CLEC4E CLEC7A MASP1 CLEC6A UBA3 ARSA MAP3K14 UBE2M TEC KIR3DS1 TREM1 SIRPB1 RELA CLEC5A CD300LB SIGLEC15 TNFRSF1B SIGLEC14 KIR2DS2 KIR2DS4 NCR2 RELB CD300E PIK3R4 ANPEP CTSG CTSD MME ATP6AP2 DIAPH1 ARSB CPB2 CTSA CASP4 AIM2 NLRP1 CARD9 MYO5A RAB27A WASL NFKB1 NFKB2 CD36 RAB6A CD44 CYFIP2 CYFIP1 NCKAP1 AHCYL1 NCF1 NCF2 NCF4 BRK1 PIK3CB TREM2 KLRK1 GRAP2 KLRC2 ITGAV TYROBP LCP2 RAC1 NCK1 KLRD1 PTAFR VAV3 PDPK1 CYBB CYBA VAV1 VAV2 MAPKAPK3 ACAA1 ELMO1 ELMO2 CRK DOCK1 ROCK1 ITPR1 ITPR2 ITPR3 PIK3R2 CDC42 PAK1 NCKAP1L FYN WASF1 PAK3 WASF2 PAK2 WASF3 JUP NOS3 BAIAP2 PTK2 MAPK12 MAPK13 ABI2 ABI1 CTNNB1 BST2 IFNA5 IFNA4 IFNA7 IFNA6 IFNA1 IFNA2 IFNA8 IFNA13 IFNA14 IFNA16 IFNA17 IFNA10 IFNA21 CASP8 GLB1 RIPK1 TRAF2 FADD ICAM2 ICAM3 SLC15A4 CD209 VCP PRKCSH PSEN1 NCSTN MLEC PLCG2 CYLD TNFAIP3 RASGRP2 RASGRP1 IGHG4 IGHG1 IGHG2 IGKV1-12 TAX1BP1 BIRC2 BIRC3 IGKV2D-28 IGKV4-1 ASAH1 IGKV2D-30 GPR84 IGKV3-11 LYN AOC1 YES1 AGL CAPN1 CD3G ANXA2 FCGR3A IGKV2-28 SYK GYG1 IGKV3D-20 HCK MYH9 HSP90B1 FCGR1A PSAP IGKV5-2 FCGR2A WIPF1 WIPF2 WIPF3 C3AR1 TXNIP MEFV GM2A ARPC1B ARPC1A IL1B WAS MYO9B ACTG1 PYCARD NCKIPSD NLRP3 ARPC4 ARPC5 ARPC2 ARPC3 PSTPIP1 ACTR3 ACTR2 MYH2 MYO10 MYO1C IMPDH1 SUGT1 IMPDH2 FRMPD3 GMFG ABCA13 PGLYRP1 PRSS2 NHLRC3 MCEMP1 ARMC8 RNASE3 RNASE2 SCAMP1 UNC13D FLG2 FPR1 RASGRP4 A1BG FPR2 PLAC8 CRACR2A PRDX4 S100A11 GSDMD FUCA1 FUCA2 AZU1 MGST1 PA2G4 LYZ HRNR PIGR SERPINA3 MUC12 SERPINA1 SIGLEC9 MMP25 MUC13 MUC15 TIMP2 OLR1 SERPINB3 SERPINB1 AHSG NFAM1 TMC6 SERPINB6 MUCL1 MUC3A PLEKHO2 SERPINB10 MUC5AC GRN SERPINB12 AGA CFP METTL7A ERP44 LRG1 YPEL5 SIGLEC5 GHDC TMEM179B RAB3D HP EPX STK10 MUC1 RAB44 LAMP1 GLIPR1 LAMP2 TOM1 KCMF1 IST1 MUC7 OLFM4 MUC4 ILF2 MUC6 CLEC4C MUC17 CLEC4D RAB31 MUC5B RAB37 MANBA MUC21 ADAM8 NME2 DSC1 S100A9 DNAJC3 ARL8A S100A8 S100A7 AMPD3 RAB5B BRI3 UBR4 TRAPPC1 DEFA4 DEFA1 PTPRB ATP6V0D1 PTPRC NIT2 FAM47E-STBD1 ITGAM ITGB2 MAP2K1 LRMP ITGAL RAF1 FCAR ITGAX RNASET2 DDOST PKM TMBIM1 BPI ACPP CANT1 FGL2 CECR1 RAB24 CPPED1 RAB10 NFASC TSPAN14 MNDA FOLR3 CALML5 LGALS3 TBC1D10C GOLGA7 C6orf120 ALDH3B1 SLC11A1 KRT1 MIF CD4 CHIT1 SLPI CRISPLD2 DOCK2 C16orf62 TMEM63A SYNGR1 COMMD9 MAN2B1 VAT1 PTPRN2 STK11IP PRG2 B4GALT1 NBEAL2 PRG3 PPBP SLC2A3 CYSTM1 ORM1 FAF2 HBB TCIRG1 MAGT1 FRK IGHE ORM2 ACTR1B NAPRT ATP6V1E1 CTSH ATP6V1E2 QSOX1 ATP6V1G1 CTSC CD33 ATP6V0B CAP1 ATP6V0E1 GUSB ATP6V1G2 CD53 FCER1G COMMD3 RAP2C CEACAM3 ATP6V1B2 CEACAM1 RAP2B CEACAM6 ATP6V0C ATP6V0D2 CEACAM8 CD47 ATP6V1B1 DNASE1L1 ATP6V1A CD63 CSTB C1orf35 CAND1 LILRA3 ATP6V0A2 CST3 PGRMC1 ATP6V1H ATP6V0A4 CXCR1 CREG1 ATP6V0E2 ATP6V1G3 CXCR2 CD58 ATP6V1D ATP6V1C1 TXN LAIR1 GCA ATP6V1F HUWE1 ATP6V0A1 ATP6V1C2 LILRB2 LILRB3 CD81 SVIP C4BPA QPCT C4BPB CD68 LCN2 C8B RAB9B C8A FCN1 SRP14 CLU C4B MPO JUN C4A PLAU C8G COTL1 CR2 SIRPA CREBBP ENPP4 CR1 CD46 OSTF1 CD93 C1QB C1QA CD300A C1S ATAD3B OSCAR CFH C1R DOK3 ADGRG3 C5AR2 CNN2 C5AR1 CFI SDCBP C4B_2 DPP7 CPN2 MGAM CPN1 GGH C2 CDK13 DNAJC13 VTN SELL C5 TARM1 C6 MS4A3 C7 DDX3X HLA-A C9 TNFAIP6 B2M CD19 CRISP3 CD59 AP1M1 CXCL1 ELANE SLC2A5 CD55 HEBP2 CFHR2 ADGRE5 CFHR1 ADGRE3 CFHR4 HGSNAT TICAM2 CFHR3 DYNLT1 LY96 CFHR5 MMP8 TICAM1 MMP9 C1QC CD14 CKAP4 SNAP25 CHI3L1 TLR4 RAB3A LTF CLEC12A MVP MOSPD2 DEFA1B CASP10 TMEM30A CMTM6 PDAP1 GALNS PTX3 S100P VCL MRE11A RAP1B ATG7 NFATC2 UBE2L6 LAMTOR2 HERC5 TRIM25 LAMTOR1 LAMTOR3 DDX58 IRF3 UBA7 ISG15 UBE2N MAP2K6 CAB39 HVCN1 PIN1 CASP1 CASP2 CCR6 APAF1 CCR2 DYNC1LI1 APP CPNE1 SNAP23 CPNE3 CTSZ DGAT1 NLRC4 FTH1 DSN1 VAMP8 CSNK2B FTL RAB5C PLD4 PLD1 PLA2G6 TXNDC5 PLD3 TRAF3 PLD2 TLR3 IGF2R SLC44A2 LPCAT1 AGPAT2 DEFB103A DEFB103B DEFB105A DEFB105B DEFB129 DEFB128 DEFB127 DEFB126 DEFB125 DEFB124 DEFB1 DEFB123 PLA2G2A DEFB107A DEFB121 DEFB107B DEFB104B DEFB106B DEFB104A DEFB119 DEFB118 DEFB116 DEFB115 DEFB136 DEFB114 DEFB135 DEFB113 DEFB134 DEFB112 DEFB133 DEFB132 DEFB108B DEFB110 DEFB131 DEFB106A DEFB4A DEFB4B PROS1 PRCP NFKBIA IKBKG IKBKE CD177 FGB FGA UBE2D1 FGG F2 CDC34 CARD11 BCL10 ITK SERPING1 PRTN3 MALT1 CCT2 CCT8 TUBB4B DNM1 DNM3 GPI HK3 PPP2R1B PPP2R1A PRKACG PRKACA PRKACB PGAM1 FCGR3B PPP2R5D LTA4H PLAUR ALDOC ALDOA LGMN PANX1 PPP2CA PPP2CB DBNL LRRC7 PFKL CHRNB4 NOS1 GSTP1 AP2A2 CFL1 NF2 LIMK1 ATF1 ACLY ATF2 SLC27A2 ELK1 RPS6KA3 RPS6KA5 RPS6KA2 RPS6KA1 EP300 DUSP4 RAB4B KCNAB2 MEF2A TKFC MEF2C DUSP3 RAP1A DNAJC5 FOS VRK3 DUSP6 DNM2 DUSP7 CREB1 MAPKAPK2 HPSE HLA-B MAPK7 MAPK1 HLA-C MAPK3 HLA-E ALAD MAPK14 MAPK11 PGM2 PGM1 HSP90AA1 PTPRJ S100A1 LBP NEU1 APOB MUC20 BST1 GAA APRT PDZD11 ORMDL3 SNAP29 CEP290 FBXW11 TUBB SOCS1 DYNLL1 DEGS1 TANK DYNC1H1 FCN2 FCN3 COLEC10 MBL2 PRKDC ACTB SPTAN1 RAB7A XRCC6 DSP XRCC5 DSG1 GLA PKP1 CDA PRKCQ PRSS3 GSN GNS ATP8A1 UBE2D2 UBE2D3 ATP11B ATP11A HMOX2 TCN1 PYGB TRPM2 PYGL PPIE CRCP ATP8B4 DDX41 IFIH1 TBK1 RNF135 LRRFIP1 ABL1 MAVS TRIM21 SIKE1 MB21D1 ZBP1 RIPK3 TMEM173 IRF7 TRIM56 DHX9 ALOX5 POLR1C NLRC3 DTX4 IFI16 NLRP4 DHX36 STAT6 ATP7A POLR3GL CAT TREX1 POLR3A RETN POLR3B POLR3C POLR3D ANO6 POLR3E POLR3F POLR3G POLR3H POLR3K TRIM32 POLR2E POLR2F POLR2H STOM POLR2K POLR2L MAPK8 TOLLIP PTPN4 EEF1A1 EEF2 HMGB1 IKBKB NKIRAS1 NKIRAS2 MAP3K8 TTR MAP2K3 CHUK MAP2K4 RIPK2 CASP9 IRAK4 PELI1 TLR9 TLR8 TLR7 UBE2V1 PELI3 PELI2 NOD1 NOD2 AGER MAPK9 IRAK1 RAB14 S100A12 VAPA MAP2K7 MAP3K1 S100B MAPK10 TNIP2 SAA1 MYD88 NFKBIB NOS2 HMHA1 PNP PRKCE PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 ARHGAP9 AAMP PSMD3 PSMD1 ADAM10 GDI2 PRKCD FGR PTPN11 PSMA5 RAC2 PSMA6 P2RX7 PSMA3 RHOG PSMA4 PSMA1 PSMA2 RHOF PSME3 P2RX1 PSME4 PTPN6 PSME1 PSME2 UBA52 DERA PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 VNN1 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 UBB PSMB3 UBC PSMB1 GAB2 PSMF1 RPS27A HSPA8 SHFM1 PSMB8 PSMB9 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 PTGES2 COPB1 SURF4 NPC2 IDH1 BTRC SKP1 BTK IRAK2 TRAF6 TAB3 TAB2 TAB1 PAFAH1B2 MAP3K7 OTHER SEMAPHORIN INTERACTIONS%REACTOME%R-HSA-416700.1 Other semaphorin interactions SEMA4D PTPRC PLXND1 PLXNC1 SEMA6A SEMA6D SEMA7A PLXNA2 PLXNA1 ITGB1 ITGA1 PLXNB3 CD72 TREM2 SEMA3E TYROBP PLXNA4 SEMA5A SEMA4A AUTODEGRADATION OF CDH1 BY CDH1:APC C%REACTOME DATABASE ID RELEASE 72%174084 Autodegradation of Cdh1 by Cdh1:APC C PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME1 PSME2 UBA52 PSMD10 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 ANAPC15 ANAPC16 PSMB6 ANAPC7 PSMB7 UBE2C UBE2E1 PSMB4 UBE2D1 ANAPC10 PSMB5 ANAPC11 PSMB2 UBB CDC23 PSMB3 CDC26 CDC27 UBC CDC16 PSMB1 ANAPC4 PSMF1 ANAPC5 ANAPC1 RPS27A ANAPC2 SHFM1 PSMB8 PSMB9 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 FZR1 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 DOWNSTREAM SIGNALING OF ACTIVATED FGFR4%REACTOME%R-HSA-5654716.1 Downstream signaling of activated FGFR4 HRAS FRS2 PTPN11 FRS3 FGF16 KLB FGF18 NRAS GAB1 PIK3R1 FGF19 FGFR4 FGF6 PIK3CA FGF9 PLCG1 SOS1 FGF20 FGF1 FGF2 FGF23 FGF4 2-LTR CIRCLE FORMATION%REACTOME%R-HSA-164843.2 2-LTR circle formation PSIP1 BANF1 HMGA1 LIG4 XRCC6 XRCC4 XRCC5 KERATAN SULFATE DEGRADATION%REACTOME DATABASE ID RELEASE 72%2022857 Keratan sulfate degradation LUM KERA FMOD GLB1 HEXB PRELP HEXA GNS OMD OGN GLB1L LOSS OF FUNCTION OF FBXW7 IN CANCER AND NOTCH1 SIGNALING%REACTOME DATABASE ID RELEASE 72%2644607 Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling CUL1 SKP1 RBX1 NOTCH1 RNA POLYMERASE II TRANSCRIPTION ELONGATION%REACTOME%R-HSA-75955.2 RNA Polymerase II Transcription Elongation TCEB3C TCEB3B POLR2E POLR2F POLR2H TCEB3CL2 POLR2K CCNH POLR2L TCEB3 GTF2H1 TCEB2 GTF2H2 TCEB1 GTF2H3 TCEB3CL GTF2H4 GTF2H5 ERCC3 ERCC2 TCEA1 CCNK CCNT2 CCNT1 SSRP1 WDR61 CTDP1 NCBP1 LEO1 SUPT16H NCBP2 SUPT4H1 SUPT5H GTF2F1 GTF2F2 CDK7 POLR2A POLR2B POLR2C POLR2D POLR2G NELFB MNAT1 NELFA NELFCD POLR2I POLR2J NELFE CDC73 CDK9 ELL AFF4 CTR9 MLLT1 RTF1 MLLT3 SUPT6H IWS1 EAF1 EAF2 PAF1 P75NTR REGULATES AXONOGENESIS%REACTOME DATABASE ID RELEASE 72%193697 p75NTR regulates axonogenesis OMG MAG LINGO1 MCF2 NGFR ARHGDIA RHOA RTN4 NGF NEGATIVE REGULATION OF TCF-DEPENDENT SIGNALING BY DVL-INTERACTING PROTEINS%REACTOME DATABASE ID RELEASE 72%5368598 Negative regulation of TCF-dependent signaling by DVL-interacting proteins CCDC88C DVL2 DVL1 DVL3 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS%REACTOME%R-HSA-983695.3 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers IGKV3-11 LYN VAV1 PIK3AP1 STIM1 PLCG2 BLK PIK3CD ORAI2 ORAI1 PTPN6 ITPR1 PIK3R1 ITPR2 IGKV2-28 DAPP1 ITPR3 SYK SOS1 FYN IGKV3D-20 IGKV1-12 BLNK CD79B CD79A AHCYL1 IGKV2D-28 IGKV4-1 CD19 IGKV2D-30 CD22 BTK IGKV5-2 TRPC1 SH3KBP1 NCK1 DISORDERS OF DEVELOPMENTAL BIOLOGY%REACTOME DATABASE ID RELEASE 72%9675151 Disorders of developmental biology HDAC3 NCOR1 TBL1X CAMK4 HDAC1 TBL1XR1 GPS2 SIN3A PRKACA NCOR2 ION INFLUX EFFLUX AT HOST-PATHOGEN INTERFACE%REACTOME%R-HSA-6803544.1 Ion influx efflux at host-pathogen interface PDZD11 ATP7A SLC11A1 ATOX1 REACTIONS SPECIFIC TO THE HYBRID N-GLYCAN SYNTHESIS PATHWAY%REACTOME DATABASE ID RELEASE 72%975574 Reactions specific to the hybrid N-glycan synthesis pathway MGAT3 PERK REGULATES GENE EXPRESSION%REACTOME DATABASE ID RELEASE 72%381042 PERK regulates gene expression DIS3 CXCL8 NFYA NFYB NFYC EIF2AK3 HERPUD1 DCP2 CEBPB CEBPG PARN CCL2 EIF2S2 EIF2S1 EXOSC7 EIF2S3 EXOSC6 ATF3 EXOSC5 EXOSC4 DDIT3 ATF6 EXOSC9 EXOSC8 ATF4 EXOSC3 IGFBP1 EXOSC2 EXOSC1 HSPA5 ASNS KHSRP TWIK-RELATED ALKALINE PH ACTIVATED K+ CHANNEL (TALK)%REACTOME%R-HSA-1299361.1 TWIK-related alkaline pH activated K+ channel (TALK) KCNK17 KCNK16 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION%REACTOME DATABASE ID RELEASE 72%2730905 Role of LAT2 NTAL LAB on calcium mobilization PDPK1 IGKV3-11 IGKV1-12 LYN LAT2 IGKV2D-28 IGKV4-1 GAB2 PIK3R1 PIK3CB IGKV2-28 IGKV2D-30 IGHE PIK3R2 PIK3CA SYK SOS1 IGKV5-2 FYN IGKV3D-20 INTRACELLULAR OXYGEN TRANSPORT%REACTOME%R-HSA-8981607.2 Intracellular oxygen transport MB NGB CYGB PEPTIDE LIGAND-BINDING RECEPTORS%REACTOME%R-HSA-375276.5 Peptide ligand-binding receptors CXCL6 CXCL9 CXCL3 GPER1 CXCL13 CXCL2 QRFPR CX3CL1 SSTR1 CXCL5 SSTR2 CXCL16 SSTR4 CCRL2 SSTR5 CCR9 CCR8 CCR7 CCR6 CCR4 CCR3 CCK CCR2 XCL2 ACKR1 RXFP4 XCL1 GRPR CX3CR1 RXFP3 CCL13 PROK2 CCL11 PROK1 CCL3L1 CCL3L3 TRHR CXCR5 GALR3 CXCR6 APP GALR2 CCL7 GALR1 CCL5 RXFP1 CXCR3 RXFP2 CCL4 CCL3 CCL2 PNOC CCL1 CCL19 CCL17 CCL16 CCR10 CCL25 CCR1 CCL22 SSTR3 XCR1 CCL21 CCL20 CXCL10 CXCL11 ACKR4 ACKR3 ACKR2 CCL28 MCHR1 CCL27 MC2R TRH INSL5 OXTR AVP EDNRA EDNRB UTS2R MC1R GPR37L1 RLN2 UTS2B RLN3 NLN ANXA1 AGT PPY NTSR1 NTSR2 NMB NMBR MC4R NMS NMU QRFP INSL3 BRS3 CCKAR EDN1 EDN2 AVPR2 EDN3 AVPR1B AVPR1A CCKBR NPB MC3R NPW KISS1R F2RL1 F2RL2 F2RL3 NPSR1 PMCH NPY2R GHSR NPY1R APLNR NTS NPS C3 PSAP PYY NMUR2 NMUR1 MC5R MLNR HEBP1 BDKRB2 BDKRB1 C3AR1 NPY5R CORT NPY4R OPRL1 OPRK1 KISS1 KNG1 F2R F2 PF4 FPR1 FPR2 AGTR1 NPY TACR2 TACR3 TAC3 TACR1 TAC1 CXCL8 PPBP OPRD1 GRP OPRM1 CXCR1 CXCR2 POMC SAA1 C5AR2 C5AR1 C5 CXCL1 CXCL12 CCR5 CXCR4 PDYN AGTR2 FPR3 NPBWR1 NPBWR2 HCRT GPR37 PROKR1 PROKR2 UTS2 ECE1 PRLHR HCRTR2 HCRTR1 APLN NPFFR2 NPFFR1 NPFF KEL PENK MLN GAL PRLH XK MCHR2 OXT SST LYSOSPHINGOLIPID AND LPA RECEPTORS%REACTOME DATABASE ID RELEASE 72%419408 Lysosphingolipid and LPA receptors S1PR3 S1PR1 LPAR1 LPAR2 S1PR2 LPAR3 S1PR5 S1PR4 LPAR5 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING%REACTOME DATABASE ID RELEASE 72%879415 Advanced glycosylation endproduct receptor signaling HMGB1 DDOST CAPZA1 CAPZA2 AGER S100A12 APP PRKCSH S100B LGALS3 SAA1 MAPK1 MAPK3 DEGRADATION OF THE EXTRACELLULAR MATRIX%REACTOME DATABASE ID RELEASE 72%1474228 Degradation of the extracellular matrix NCSTN LAMA5 CDH1 LAMA3 LAMB3 LAMB1 TIMP1 CASP3 PHYKPL CAPN15 OPTC KLK7 MMP20 MMP24 ADAM17 CTSV CTSG TPSAB1 CTSD CTSS MMP10 CTSL MMP12 CTSK MMP11 CTSB MMP14 MMP13 HSPG2 MMP16 MMP15 MMP17 MMP19 TMPRSS6 SPP1 MMP1 MMP2 MMP3 CAST CAPNS1 CAPNS2 CAPN2 CAPN8 CAPN1 CAPN9 CMA1 CAPN6 CAPN7 CAPN5 CAPN3 ADAM15 ADAM9 HTRA1 NID1 CD44 SCUBE3 SCUBE1 ELANE BMP1 MMP8 TLL2 KLK2 MMP7 MMP9 TLL1 FURIN ADAM10 PLG SPOCK3 CAPN13 COL17A1 CAPN14 COL18A1 COL15A1 CAPN11 COL16A1 CAPN12 COL13A1 COL14A1 CAPN10 COL12A1 COL19A1 COL26A1 COL25A1 COL23A1 A2M PRSS1 COL9A1 COL9A3 COL9A2 PRSS2 KLKB1 ADAMTS4 ADAMTS5 ADAMTS1 MMP25 TIMP2 ADAMTS8 ADAMTS9 ADAMTS16 ADAMTS18 BCAN ADAM8 BSG LAMC2 CTRB2 CTRB1 DCN LAMC1 PSEN1 DIGESTION AND ABSORPTION%REACTOME DATABASE ID RELEASE 72%8963743 Digestion and absorption SI LCT ALPI CHIA AMY2A CHIT1 PNLIP AMY1A AMY2B AMY1B TREH AMY1C GUCA2B GUCA2A PIR GUCY2C LIPF MGAM PNLIPRP1 PNLIPRP3 SLC2A2 SLC5A1 SLC2A5 RSC1A1 CLPS VOLTAGE GATED POTASSIUM CHANNELS%REACTOME DATABASE ID RELEASE 72%1296072 Voltage gated Potassium channels KCNG2 KCNS3 KCNV1 KCNV2 KCNF1 KCNQ1 KCNA1 KCNA2 KCNA3 KCNA4 KCNA5 KCNA6 KCNA7 KCNQ2 KCNQ3 KCNQ4 KCNQ5 KCNAB1 KCNB2 KCNAB2 KCNAB3 KCNS1 KCNS2 KCNA10 KCNG1 KCNG3 KCNG4 KCNC1 KCNH1 KCNC3 KCNH3 KCNC4 KCNH4 KCND1 KCNH5 KCND2 KCNH2 KCNH6 KCND3 KCNH7 KCNH8 KCNB1 KCNC2 NEGATIVE REGULATION OF FGFR1 SIGNALING%REACTOME%R-HSA-5654726.2 Negative regulation of FGFR1 signaling PPP2CA PPP2CB BRAF FRS2 PTPN11 SPRY2 CBL UBA52 FGF6 FGF9 ANOS1 PPP2R1A FGF20 FGF1 FGF2 FGF23 FGF3 MKNK1 FGF22 FGF10 FGF4 UBB UBC RPS27A MAPK1 MAPK3 SYNTHESIS OF UDP-N-ACETYL-GLUCOSAMINE%REACTOME%R-HSA-446210.2 Synthesis of UDP-N-acetyl-glucosamine RENBP UAP1 AMDHD2 GFPT2 NAGK PGM3 GFPT1 GNPNAT1 THE PHOTOTRANSDUCTION CASCADE%REACTOME DATABASE ID RELEASE 72%2514856 The phototransduction cascade CNGA1 RHO RCVRN SAG METAP1 PDE6B METAP2 PDE6A NMT1 CNGB1 PRKCA GNB1 NMT2 GNGT1 FNTA GUCY2D PRKCQ GUCY2F GNAT1 GUCA1B RGS9BP GUCA1A GUCA1C CAMKMT GRK1 GRK7 PPEF1 FNTB SLC24A1 PDE6G TICAM1,TRAF6-DEPENDENT INDUCTION OF TAK1 COMPLEX%REACTOME DATABASE ID RELEASE 72%9014325 TICAM1,TRAF6-dependent induction of TAK1 complex UBC RPS27A UBA52 TRAF6 TAB3 TAB2 TAB1 TICAM1 UBB MAP3K7 TLR3 REGULATION OF GENE EXPRESSION IN LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS%REACTOME%R-HSA-210744.2 Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells MAML2 ONECUT3 MAML1 ONECUT1 EP300 RBPJ KAT2B HES1 KAT2A HNF1B SNW1 MAML3 MAMLD1 NEUROG3 CREBBP NOTCH1 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION%REACTOME DATABASE ID RELEASE 72%381340 Transcriptional regulation of white adipocyte differentiation NR2F2 TBL1X ZNF467 THRAP3 TGS1 CCND3 HELZ2 CDK19 MED13L ADIPOQ CCNC ZNF638 TBL1XR1 SMARCD3 FAM120B WNT10B RELA CEBPD FABP4 EP300 SREBF2 MED30 CHD9 MED31 LEP SLC2A4 CARM1 CEBPA KLF5 MED19 EGR2 MED16 MED15 MED18 MED17 MED12 MED11 PCK1 WNT1 MED14 MED13 MED10 EBF1 NFKB1 KLF4 CDK4 CEBPB MED27 CD36 MED26 MED29 NCOA1 MED28 MED23 MED22 ADIRF NCOA2 NCOR2 MED25 PPARGC1A CREBBP NCOA6 MED24 NCOA3 NCOR1 HDAC3 MED21 MED20 TGFB1 PLIN1 LPL ANGPTL4 PPARG RXRA PPARA TNF MED1 MED8 MED9 MED4 MED6 MED7 CDK8 O2 CO2 EXCHANGE IN ERYTHROCYTES%REACTOME DATABASE ID RELEASE 72%1480926 O2 CO2 exchange in erythrocytes CYB5R1 CYB5R4 CYB5RL AQP1 HBB RHAG SLC4A1 CA1 CA2 CA4 HBA2 HBA1 CYB5R2 PTEN REGULATION%REACTOME%R-HSA-6807070.2 PTEN Regulation CBX6 RBBP4 RBBP7 MTA2 MTA3 MECOM MBD3 SUZ12 GATAD2B GATAD2A CSNK2A1 CSNK2A2 KDM1A BMI1 RNF2 CSNK2B CBX8 PREX2 XIAP PHC2 USP13 TNKS PHC1 RING1 TNKS2 CBX4 WWP2 CBX2 RNF146 STUB1 FRK PML OTUD3 TNRC6C PHC3 TNRC6A RRAGA TNRC6B RRAGC RRAGB RRAGD MKRN1 TP53 JUN MOV10 AGO3 AGO4 AGO1 AGO2 PPARG AKT2 PSMD8 AKT3 PSMD9 MLST8 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 RPTOR PSMD3 AKT1 PSMD1 PSMA5 PSMA6 PSMA3 SALL4 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 ATN1 UBA52 NR2E1 MAF1 PSMD10 SNAI1 PSMB11 PSMD12 SNAI2 ATF2 PSMD11 PSMD14 PSMD13 CHD4 PSMA7 PSMB10 TRIM27 PSMA8 PSMB6 PSMB7 MTOR PSMB4 PSMB5 PSMB2 LAMTOR2 UBB PSMB3 LAMTOR1 LAMTOR4 LAMTOR3 UBC LAMTOR5 PSMB1 PSMF1 RPS27A SHFM1 PSMB8 PSMB9 MAPK1 PSMC5 PSMC6 USP7 MAPK3 PSMC3 EGR1 PSMC4 PSMC1 PSMC2 REST NEDD4 EZH2 CHD3 SLC38A9 EED HDAC3 HDAC5 RHEB HDAC7 HDAC2 HDAC1 PTEN MTA1 LACTOSE SYNTHESIS%REACTOME%R-HSA-5653890.1 Lactose synthesis LALBA B4GALT1 SLC2A1 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER%REACTOME%R-HSA-3645790.2 TGFBR2 Kinase Domain Mutants in Cancer TGFB1 TGFBR1 TGFBR2 AMINO ACIDS REGULATE MTORC1%REACTOME DATABASE ID RELEASE 72%9639288 Amino acids regulate mTORC1 FLCN SEC13 MTOR SEH1L NPRL2 NPRL3 LAMTOR2 WDR59 LAMTOR1 LAMTOR4 LAMTOR3 LAMTOR5 TCIRG1 MIOS ATP6V1E1 ATP6V1E2 ATP6V1G1 WDR24 SESN2 ATP6V0B ATP6V0E1 ATP6V1G2 GATSL3 ATP6V1B2 SESN1 RRAGA ATP6V0C ATP6V0D2 ATP6V1B1 RRAGC ATP6V1A RRAGB RRAGD ATP6V1H C7orf60 ATP6V0E2 ATP6V1G3 ATP6V1D ATP6V1C1 ATP6V1F SLC38A9 ATP6V1C2 SH3BP4 FNIP1 FNIP2 C12orf66 RHEB ITFG2 KPTN DEPDC5 MLST8 GATSL2 SZT2 RPTOR ATP6V0D1 TERMINATION OF TRANSLESION DNA SYNTHESIS%REACTOME%R-HSA-5656169.1 Termination of translesion DNA synthesis POLK RPA1 POLE RPA2 POLD3 POLH POLD4 RFC1 USP43 RPA3 POLD1 POLD2 ISG15 RFC5 REV1 RFC3 RFC4 RFC2 USP10 UBA52 POLE4 KIAA0101 UBE2L6 POLE2 UBB TRIM25 POLE3 UBC RPS27A POLI PCNA UBA7 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL%REACTOME%R-HSA-1855167.2 Synthesis of pyrophosphates in the cytosol IP6K3 NUDT4 IPPK NUDT11 NUDT10 ITPK1 PPIP5K1 PPIP5K2 IP6K1 NUDT3 OPSINS%REACTOME DATABASE ID RELEASE 72%419771 Opsins OPN1LW RHO OPN4 OPN1MW OPN1MW2 OPN3 RGR RRH OPN5 OPN1SW SIGNALING BY TGF-BETA FAMILY MEMBERS%REACTOME DATABASE ID RELEASE 72%9006936 Signaling by TGF-beta family members PPP1CC MEN1 CCNC TFDP1 RBL1 TFDP2 UBE2M FSTL1 E2F4 CCNK SERPINE1 SKIL STUB1 TGIF1 TGIF2 USP9X ATP1B4 SKI TRIM33 CHRDL1 NEDD8 INHBB MTMR4 INHBA PPP1CB SMAD7 WWTR1 UCHL5 USP15 BMP2 BMP10 XPO1 FURIN PPP1CA CDK8 RNF111 SMAD2 UBA52 SMAD3 FST FOXH1 ACVR1B ACVR2B ACVR2A FSTL3 DRAP1 ACVR1C JUNB SMURF2 UBE2D1 UBB SMAD6 UBC PARP1 CCNT2 CER1 CCNT1 RPS27A SP1 MYC UBE2D3 CDKN2B PMEPA1 BAMBI STRAP SNW1 NEDD4L CBL PPP1R15A E2F5 NCOR2 CDK9 PPM1A NCOR1 TGFB1 SMAD4 SMURF1 ACVRL1 ARHGEF18 CGN BMPR2 AMHR2 F11R PRKCZ AMH NOG TGFBR1 GDF2 RHOA SMAD1 SMAD9 TGFBR2 SMAD5 FKBP1A GREM2 PARD6A ZFYVE16 PARD3 BMPR1B BMPR1A HDAC1 NEF MEDIATED DOWNREGULATION OF CD28 CELL SURFACE EXPRESSION%REACTOME DATABASE ID RELEASE 72%164939 Nef mediated downregulation of CD28 cell surface expression CD28 AP2M1 RRNA PROCESSING IN THE NUCLEUS AND CYTOSOL%REACTOME DATABASE ID RELEASE 72%8868773 rRNA processing in the nucleus and cytosol RPL26 WBSCR22 RPL29 MPHOSPH10 RPS4X RPL28 NOL11 NOL12 RPS3A NAT10 UTP14A UTP14C RPL41 HEATR1 NOL9 NOL6 RPL3L PES1 BOP1 MPHOSPH6 RPP30 FBL RPP38 DIMT1 UTP11L RPP21 RPP25 EMG1 UTP20 RPP40 RCL1 RBM28 DDX49 DDX47 UTP15 DDX52 SENP3 UTP18 BMS1 RPL10 RPP14 RPL12 RPL11 RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPS9 RPS7 NHP2L1 RPS8 RPS5 RPS6 RPSA SKIV2L2 CSNK1D CSNK1E RPLP1 RPLP0 TRMT112 RPLP2 RPL7A RPS27L RPL37A RPL36A RPL35A RPL22L1 RPS4Y2 RPS4Y1 XRN2 RPL39L NOP2 RPS15A NOP56 DDX21 RPL10L RPL10A RPL23A FAU DKC1 NHP2 GAR1 NOP10 RPL13A RPL27A RPS15 RPS14 RPS17 RPS16 RPS19 RPL18A RPL36AL RPS18 RPS11 RPS10 RPS13 RPS12 DIS3 UBA52 RPS26 RPS25 RPS28 RPS27 RPS29 RPS20 RPS21 RPS24 RPS23 EXOSC7 EXOSC6 RRP1 EXOSC5 EXOSC4 RRP9 WDR75 EXOSC9 EXOSC8 RRP7A PNO1 TBL3 EXOSC3 LAS1L RPS27A EXOSC2 WDR46 EXOSC1 WDR43 RIOK2 RIOK1 WDR36 TEX10 DIEXF GNL3 NIP7 PELP1 TSR3 NOC4L EXOSC10 RRP36 UTP6 UTP3 RIOK3 WDR18 WDR12 BYSL TSR1 RPL26L1 RPL4 RPL5 RPL30 FTSJ3 RPL3 EBNA1BP2 RPL32 NCL RPL31 ISG20L2 RPL34 NOP14 RPL8 RPL9 WDR3 RPL6 RPL7 NOB1 RPL36 C1D RPL35 RPL38 RPL37 DCAF13 RPL39 NOP58 KRR1 RPL21 LTV1 RPL23 FCF1 RPL22 THUMPD1 PWP2 IMP3 IMP4 CIRH1A RPL24 PDCD11 RPL27 ERI1 DHX37 INTERLEUKIN-10 SIGNALING%REACTOME DATABASE ID RELEASE 72%6783783 Interleukin-10 signaling CD80 FCER2 CXCL2 CXCL8 IL6 TIMP1 IL18 CCR2 IL1A IL1B IL10RB PTGS2 CCR5 IL10RA CSF3 CSF1 CCL3L1 IL10 CCL3L3 CCL5 IL12B IL1RN IL12A CCL4 CCL3 CCL2 IL1R1 IL1R2 CCL19 ICAM1 TNFRSF1B TNFRSF1A CCR1 CCL22 CCL20 CXCL10 TNF LIF CSF2 TYK2 CXCL1 JAK1 STAT3 FPR1 CD86 PTAFR CONJUGATION OF SALICYLATE WITH GLYCINE%REACTOME DATABASE ID RELEASE 72%177128 Conjugation of salicylate with glycine GLYAT ACSM2B GLYATL3 GLYATL2 GLYATL1 ACSM2A ACSM5 ACSM4 CREATINE METABOLISM%REACTOME DATABASE ID RELEASE 72%71288 Creatine metabolism CKB CKM SLC6A12 CKMT2 SLC6A11 SLC6A7 GAMT SLC6A8 CKMT1A GATM CKMT1B DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING%REACTOME%R-HSA-2173788.1 Downregulation of TGF-beta receptor signaling PPP1CC PMEPA1 BAMBI STRAP MTMR4 NEDD4L SMAD2 SMAD3 UBA52 PPP1R15A PPP1CB SMAD7 UCHL5 USP15 TGFB1 SMURF1 SMURF2 TGFBR1 UBB TGFBR2 UBC STUB1 RPS27A XPO1 PPP1CA DEFECTS IN COBALAMIN (B12) METABOLISM%REACTOME%R-HSA-3296469.1 Defects in cobalamin (B12) metabolism GIF MTRR CD320 MMAB ABCD4 AMN TCN2 CUBN MTR LMBRD1 MMAA MMACHC MMADHC MUT INTEGRATION OF VIRAL DNA INTO HOST GENOMIC DNA%REACTOME%R-HSA-175567.2 Integration of viral DNA into host genomic DNA PSIP1 BANF1 HMGA1 FORMATION OF A POOL OF FREE 40S SUBUNITS%REACTOME DATABASE ID RELEASE 72%72689 Formation of a pool of free 40S subunits RPL26 RPL29 RPL10L RPS4X RPL10A RPL28 RPS3A RPL23A FAU RPL41 RPL3L RPL10 RPL12 RPL13A RPL11 RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL27A RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS15 RPS14 RPS17 RPS16 RPS19 RPL18A RPL36AL RPS18 RPLP1 RPS11 RPS10 RPLP0 RPS13 RPS12 RPLP2 RPL7A RPS27L UBA52 RPL37A RPS26 RPS25 RPS28 EIF1AX RPS27 RPL36A RPS29 RPS20 RPL35A RPS21 RPS24 RPS23 EIF3M EIF3K EIF3L RPL22L1 EIF3I EIF3J EIF3G EIF3H EIF3E EIF3F EIF3C EIF3D EIF3A RPS4Y2 EIF3B RPS4Y1 RPS27A RPL26L1 RPL4 RPL39L RPL5 RPL30 RPL3 RPL32 RPL31 RPL34 RPL8 RPL9 RPL6 RPL7 RPL36 RPL35 RPL38 RPL37 RPL39 RPS15A RPL21 RPL23 RPL22 RPL24 RPL27 HATS ACETYLATE HISTONES%REACTOME%R-HSA-3214847.1 HATs acetylate histones TADA2B ZZZ3 TADA2A HIST2H2AB RBBP7 IKBKAP ING4 ING3 PAX3 HIST2H2BF SUPT3H TAF6L CCDC101 CLOCK TAF9 BRD8 ELP2 ELP3 ELP4 ELP5 ELP6 HIST3H2A JADE1 JADE3 YEATS4 TAF12 JADE2 RUVBL2 TAF10 HIST1H2AG HIST1H2AA HIST1H2AM HIST1H2AL KAT5 HIST1H2AI HIST1H2AH HIST1H2AK SUPT7L MORF4L1 KAT6B MORF4L2 HAT1 ENY2 TAF5L ATXN7 MBIP EP400 DMAP1 MEAF6 DR1 MRGBP YEATS2 TADA3 TADA1 OGT NCOA1 NCOA2 CREBBP VPS72 WDR5 MSL2 MSL3 MSL1 PHF20 USP22 KANSL1 KANSL2 KANSL3 ING5 BRD1 ACTB SAP130 HIST1H2AE HIST1H2AD HIST3H2BB ATF2 HIST1H2AC HIST1H2AB HIST1H2AJ HIST2H3A HIST1H2BF HIST1H2BE HIST1H2BH EP300 HIST1H2BG HIST2H3D HIST1H2BB HIST1H2BA HIST2H3C HIST1H2BD HIST1H2BC HIST1H3J HIST1H3A HIST1H3F HIST1H3G HIST1H3H ACTL6A HIST1H3I HIST1H3B HIST1H3C HIST1H3D HIST1H3E HIST1H4K HIST1H4L HIST1H4A HIST1H4B HIST1H4H MCRS1 HIST1H4I HIST1H4J HIST1H4C HIST1H4D KAT6A HIST1H4E HIST1H4F AK6 HIST2H2AA3 HIST2H2AA4 RUVBL1 HIST2H2AC BRPF1 BRPF3 HIST2H2BE TRRAP KAT2B KAT2A KAT8 EPC1 KAT7 HIST4H4 SUPT20H ATXN7L3 CSRP2BP HCFC1 HIST1H2BN HIST1H2BM HIST1H2BO HIST1H2BJ HIST1H2BI HIST1H2BL HIST1H2BK HIST2H4A HIST2H4B RECEPTOR MEDIATED MITOPHAGY%REACTOME DATABASE ID RELEASE 72%8934903 Receptor Mediated Mitophagy MAP1LC3B ATG5 MAP1LC3A CSNK2A2 FUNDC1 ULK1 ATG12 CSNK2B CSNK2A1 RNA POLYMERASE II HIV PROMOTER ESCAPE%REACTOME%R-HSA-167162.3 RNA Polymerase II HIV Promoter Escape GTF2F1 TAF2 GTF2B GTF2F2 CDK7 GTF2A1 POLR2A GTF2A2 POLR2B TAF1 POLR2C GTF2E1 POLR2D GTF2E2 POLR2G POLR2E MNAT1 POLR2F POLR2H POLR2I POLR2J AK6 POLR2K CCNH POLR2L GTF2H1 GTF2H2 GTF2H3 GTF2H4 TAF9B GTF2H5 TBP ERCC3 ERCC2 TAF9 TAF1L TAF15 TAF12 TAF13 TAF4B TAF10 TAF11 TAF7 TAF6 TAF5 TAF7L TAF4 TAF3 SHC1 EVENTS IN ERBB2 SIGNALING%REACTOME%R-HSA-1250196.4 SHC1 events in ERBB2 signaling HRAS NRG1 PTPN12 PRKCD PRKCA NRG2 BTC NRG3 NRG4 NRAS HBEGF EREG EGF SHC1 EGFR PRKCE SOS1 ERBB2 O-GLYCOSYLATION OF TSR DOMAIN-CONTAINING PROTEINS%REACTOME%R-HSA-5173214.1 O-glycosylation of TSR domain-containing proteins THSD7B ADAMTSL1 ADAMTS4 ADAMTS5 ADAMTS2 ADAMTS3 ADAMTSL4 ADAMTS1 ADAMTSL3 ADAMTSL2 THSD7A ADAMTS8 ADAMTS9 POFUT2 ADAMTS6 ADAMTS7 SBSPON ADAMTS20 B3GLCT CFP ADAMTS12 THBS2 THSD1 THBS1 THSD4 ADAMTS10 ADAMTS16 ADAMTS15 ADAMTS14 ADAMTS13 ADAMTS19 ADAMTS18 ADAMTS17 SEMA5A SEMA5B SPON2 SPON1 INTESTINAL INFECTIOUS DISEASES%REACTOME%R-HSA-8942233.1 Intestinal infectious diseases GUCY2C PDZD3 VPR-MEDIATED NUCLEAR IMPORT OF PICS%REACTOME%R-HSA-180910.2 Vpr-mediated nuclear import of PICs NUP85 TPR NUP88 NUP43 RAE1 RANBP2 NUP107 NUP155 NUP188 PSIP1 BANF1 KPNA1 HMGA1 NUP153 NUP62 NUP35 NUPL2 NDC1 NUP214 SEC13 NUP37 NUP133 NUP210 NUP93 NUP50 NUP54 POM121 NUP205 AAAS NUP160 AMPLIFICATION OF SIGNAL FROM UNATTACHED KINETOCHORES VIA A MAD2 INHIBITORY SIGNAL%REACTOME DATABASE ID RELEASE 72%141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal PPP2R5B PPP2R5A PPP1CC CLASP1 DYNC1H1 NDE1 NUP107 PPP2R5C ERCC6L ZWILCH BUB1B CASC5 CDC20 PPP2R1B PPP2R1A KNTC1 DYNC1LI1 BIRC5 DYNC1LI2 CLIP1 RPS27 ZW10 MAD1L1 SEC13 CDCA8 NUP133 PMF1 SKA1 AURKB SKA2 DSN1 PPP2R5D RCC2 PLK1 NDC80 ZWINT KIF18A SGOL2 SGOL1 NUF2 SPDL1 NDEL1 NUDC DYNLL2 KIF2A INCENP KIF2C KIF2B ITGB3BP MIS12 CENPA NSL1 NUP160 CENPC PPP2CA BUB3 PPP2CB BUB1 NUP85 DYNC1I1 CLASP2 CENPT CENPU NUP43 CENPE APITD1 AHCTF1 CENPF RANGAP1 CENPH CENPI TAOK1 RANBP2 CENPK CENPL CENPM CENPN B9D2 CENPO CENPP CENPQ SPC24 MAD2L1 SPC25 NUP37 DYNLL1 CKAP5 MAPRE1 PAFAH1B1 XPO1 DYNC1I2 PPP2R5E CONDENSATION OF PROPHASE CHROMOSOMES%REACTOME%R-HSA-2299718.1 Condensation of Prophase Chromosomes SMC4 SMC2 HIST1H2AE HIST1H2AD HIST3H2BB SET HIST1H2AC HIST1H2AB NCAPH2 NCAPG2 HIST1H2AJ HIST2H3A NCAPD3 HIST1H2BF HIST1H2BE HIST1H2BH HIST1H2BG HIST2H3D MCPH1 HIST1H2BB HIST1H2BA PLK1 HIST2H3C HIST1H2BD HIST1H2BC H2AFB1 CCNB1 HIST3H3 HIST1H3J HIST1H3A HIST1H3F HIST1H3G CDK1 HIST1H3H HIST1H3I HIST1H3B HIST1H3C HIST1H3D RB1 HIST1H3E H3F3B HIST1H4K HIST1H4L H3F3A H2BFS HIST1H4A HIST1H4B HIST1H4H HIST1H4I HIST1H4J HIST1H4C HIST1H4D HIST1H4E HIST1H4F HIST2H2AA3 HIST2H2AA4 HIST2H2AC H2AFJ H2AFZ H2AFX H2AFV HIST2H2BE HIST4H4 HIST1H2BN HIST1H2BM SETD8 HIST1H2BO HIST1H2BJ HIST1H2BI HIST1H2BL HIST1H2BK HIST2H4A HIST2H4B RHO GTPASES ACTIVATE NADPH OXIDASES%REACTOME DATABASE ID RELEASE 72%5668599 RHO GTPases Activate NADPH Oxidases CYBB CYBA MAPK14 PRKCD PIK3R4 PRKCA MAPK11 RAC2 PRKCZ NOX1 NCF1 NCF2 NCF4 PIN1 NOXO1 S100A9 S100A8 MAPK1 RAC1 NOX3 PIK3C3 NOXA1 MAPK3 PRKCB DEFECTIVE SLC22A18 CAUSES LUNG CANCER (LNCR) AND EMBRYONAL RHABDOMYOSARCOMA 1 (RMSE1)%REACTOME DATABASE ID RELEASE 72%5619066 Defective SLC22A18 causes lung cancer (LNCR) and embryonal rhabdomyosarcoma 1 (RMSE1) SLC22A18 SYNTHESIS OF KETONE BODIES%REACTOME%R-HSA-77111.5 Synthesis of Ketone Bodies ACSS3 AACS ACAT1 BDH2 HMGCLL1 BDH1 HMGCS2 HMGCL DEFECTIVE MAN1B1 CAUSES MRT15%REACTOME DATABASE ID RELEASE 72%4793950 Defective MAN1B1 causes MRT15 MAN1B1 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS%REACTOME%R-HSA-2122948.2 Activated NOTCH1 Transmits Signal to the Nucleus NCSTN DNER ADAM10 APH1B DTX1 DTX2 CNTN1 ARRB2 DLK1 UBA52 PSENEN NUMB ARRB1 ITCH DLL1 DLL4 NEURL1B UBB JAG2 ADAM17 JAG1 MIB2 MIB1 DTX4 UBC NEURL1 RPS27A PSEN2 PSEN1 APH1A NOTCH1 REACTIONS SPECIFIC TO THE COMPLEX N-GLYCAN SYNTHESIS PATHWAY%REACTOME DATABASE ID RELEASE 72%975578 Reactions specific to the complex N-glycan synthesis pathway CHST10 FUT3 CGA FUT8 FUCA1 MGAT2 CHST8 MAN2A2 MAN2A1 LHB METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS%REACTOME%R-HSA-196849.1 Metabolism of water-soluble vitamins and cofactors MMAB PPCS PNPO SLC19A3 SLC19A1 SLC19A2 SLC25A32 MTHFR MTHFS BST1 PDXK MTHFD1 MTHFD2 SHMT2 SHMT1 HLCS THTPA RFK NMRK2 NMRK1 ABCD4 SLC2A1 SLC2A3 PDZD11 DHFR NAPRT SLC5A6 FASN AOX1 SLC5A8 CYP8B1 ABCC1 PTGIS CTRC NMNAT3 NMNAT2 ENPP2 ENPP1 NMNAT1 ENPP3 GSTO2 CD38 GSTO1 PC PANK4 NNMT CYB5R3 PANK2 PANK3 MTRR PANK1 AASDHPPT FLAD1 QPRT MTHFD2L GIF ALDH1L1 ALDH1L2 CARKD DHFRL1 AMN NUDT12 ACACB ACACA COASY PTGS2 APOA1BP VNN1 VNN2 PRSS1 SLC52A2 SLC52A3 CD320 SLC52A1 NAMPT SLC22A13 PRSS3 PARP6 FOLR2 PARP4 SLC46A1 PARP9 PARP8 MTR NADSYN1 NADK GPHN MCCC2 MCCC1 LMBRD1 MMAA MUT NT5E PCCA MTHFD1L PCCB ACP5 TCN2 TCN1 NADK2 MOCS2 MOCS3 SLC25A16 PARP16 PARP14 SLC25A19 PARP10 PPCDC SLC23A2 SLC23A1 CUBN RNLS TPK1 CTRB2 CTRB1 MOCOS MMACHC BTD MMADHC CYB5A WNT LIGAND BIOGENESIS AND TRAFFICKING%REACTOME DATABASE ID RELEASE 72%3238698 WNT ligand biogenesis and trafficking VPS26A VPS35 TMED5 WLS PORCN WNT1 WNT3 WNT4 WNT16 WNT5B WNT3A WNT11 WNT10B WNT10A WNT5A WNT9B WNT7B WNT6 WNT7A WNT9A WNT8A WNT2 WNT8B SNX3 VPS29 WNT2B NUCLEAR ENVELOPE BREAKDOWN%REACTOME%R-HSA-2980766.2 Nuclear Envelope Breakdown NUP85 TPR LMNB1 NUP88 NUP43 PRKCA RAE1 RANBP2 LPIN1 LPIN2 NUP107 NEK9 NUP155 LPIN3 NUP188 NEK6 NEK7 BANF1 NUP153 NUP62 LEMD2 NUP35 NUPL2 NDC1 NUP214 SEC13 NUP37 CTDNEP1 NUP133 NUP210 CNEP1R1 PLK1 NUP93 NUP50 CCNB1 NUP54 CDK1 EMD VRK1 LEMD3 POM121 NUP205 AAAS CCNB2 NUP160 PRKCB GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK%REACTOME DATABASE ID RELEASE 72%881907 Gastrin-CREB signalling pathway via PKC and MAPK MMP3 RPS6KA2 GAST RPS6KA1 HRAS PRKCA NRAS HBEGF CREB1 EGFR SOS1 MAPK7 MAPK1 CCKBR MAPK3 RPS6KA3 REMOVAL OF THE FLAP INTERMEDIATE%REACTOME DATABASE ID RELEASE 72%69166 Removal of the Flap Intermediate RPA1 RPA2 POLD3 POLD4 RPA3 POLD1 POLA1 POLD2 POLA2 DNA2 PRIM2 PRIM1 FEN1 PCNA DEADENYLATION OF MRNA%REACTOME DATABASE ID RELEASE 72%429947 Deadenylation of mRNA EIF4E EIF4G1 TNKS1BP1 ZCCHC11 PAIP1 CNOT6L PABPC1 EIF4B CNOT10 PARN CNOT4 CNOT6 ZCCHC6 CNOT7 EIF4A2 CNOT11 EIF4A1 CNOT1 PAN2 PAN3 CNOT2 CNOT3 CNOT8 RQCD1 EIF4A3 SIGNALLING TO STAT3%REACTOME%R-HSA-198745.1 Signalling to STAT3 STAT3 NTRK1 NGF NGF PROCESSING%REACTOME DATABASE ID RELEASE 72%167060 NGF processing FURIN PCSK6 NGF PCSK5 GALACTOSE CATABOLISM%REACTOME%R-HSA-70370.2 Galactose catabolism GALK1 GALT PGM2 PGM2L1 GALE TRANSLESION SYNTHESIS BY POLI%REACTOME DATABASE ID RELEASE 72%5656121 Translesion synthesis by POLI RPA1 RPA2 RFC1 MAD2L2 RPA3 RFC5 REV1 RFC3 RFC4 UBB RFC2 REV3L UBC RPS27A UBA52 POLI PCNA WAX AND PLASMALOGEN BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 72%8848584 Wax and plasmalogen biosynthesis AWAT1 AWAT2 AGPS DHRS7B GNPAT FAR1 FAR2 MITOCHONDRIAL ABC TRANSPORTERS%REACTOME%R-HSA-1369007.1 Mitochondrial ABC transporters ABCB10 ABCB7 ABCB6 ABCB8 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R)%REACTOME%R-HSA-2404192.2 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) PDPK1 IGF2 FRS2 PTPN11 FGF16 TRIB3 FGF7 FGF18 TLR9 GAB1 IGF1 PIK3R1 PIK3R2 FGF6 PIK3CA FGF9 SOS1 FGF20 FGF1 FGF2 FGF23 FGF3 FGF22 PIK3C3 FGF10 FGF4 HRAS PIK3R4 IGF1R CILP KLB IRS4 IRS1 FLT3 NRAS PDE3B IRS2 THEM4 FLT3LG GAB2 FGF19 PIK3CB FGFR4 AKT2 ACTIVATION OF MATRIX METALLOPROTEINASES%REACTOME DATABASE ID RELEASE 72%1592389 Activation of Matrix Metalloproteinases MMP3 PLG SPOCK3 COL18A1 CMA1 TIMP1 MMP25 TIMP2 PRSS1 MMP24 CTSV CTSG TPSAB1 MMP10 CTSK MMP11 MMP14 MMP13 PRSS2 MMP16 ELANE MMP15 MMP17 CTRB2 CTRB1 KLKB1 MMP8 KLK2 MMP7 MMP9 FURIN MMP1 MMP2 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1%REACTOME%R-HSA-174178.2 APC C:Cdh1 mediated degradation of Cdc20 and other APC C:Cdh1 targeted proteins in late mitosis early G1 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 UBA52 CDC20 PSMD10 PTTG1 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 ANAPC15 AURKB ANAPC16 AURKA PSMB6 ANAPC7 PSMB7 UBE2C PLK1 UBE2E1 PSMB4 UBE2D1 ANAPC10 PSMB5 ANAPC11 PSMB2 UBB CDC23 PSMB3 CDC26 CDC27 UBC CDC16 PSMB1 ANAPC4 PSMF1 ANAPC5 ANAPC1 RPS27A ANAPC2 SHFM1 PSMB8 PSMB9 SKP2 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 FZR1 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 POTASSIUM TRANSPORT CHANNELS%REACTOME%R-HSA-1296067.1 Potassium transport channels KCNJ1 KCNJ10 KCNJ16 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES%REACTOME%R-HSA-2022090.3 Assembly of collagen fibrils and other multimeric structures LAMA3 COL18A1 LAMB3 COL15A1 COL11A1 COL11A2 COL10A1 COL27A1 COL24A1 COL1A1 COL3A1 COL2A1 COL1A2 COL4A2 COL5A1 COL4A1 COL6A2 COL7A1 COL4A4 COL5A3 COL5A2 COL6A1 COL4A3 COL8A2 PLEC COL9A1 MMP20 COL6A3 CTSV COL4A5 COL8A1 CTSS COL9A3 CTSL COL6A6 COL9A2 CTSB COL6A5 MMP13 PXDN MMP3 LOXL3 LOXL4 ITGB4 LOXL1 LOXL2 ITGA6 PCOLCE LOX CD151 LAMC2 BMP1 TLL2 MMP7 MMP9 TLL1 DEFECTIVE ABCC8 CAN CAUSE HYPOGLYCEMIAS AND HYPERGLYCEMIAS%REACTOME DATABASE ID RELEASE 72%5683177 Defective ABCC8 can cause hypoglycemias and hyperglycemias ABCC8 KCNJ11 DEFECTIVE RFT1 CAUSES RFT1-CDG (CDG-1N)%REACTOME%R-HSA-4570571.1 Defective RFT1 causes RFT1-CDG (CDG-1n) RFT1 E3 UBIQUITIN LIGASES UBIQUITINATE TARGET PROTEINS%REACTOME DATABASE ID RELEASE 72%8866654 E3 ubiquitin ligases ubiquitinate target proteins UBE2A PRKDC RNF40 UBA52 RNF181 HIST1H2BF HIST1H2BE HIST1H2BH UBE2L3 HIST1H2BG HIST1H2BB HIST1H2BA UBE2E1 RAD18 UBE2D1 HIST1H2BD HIST1H2BC UBB UBC BCL10 RNF20 UBE2J2 RPS27A WDR61 UBE2D2 UBE2D3 LEO1 HLTF RRAGA UBE2N WAC RNF144A CDC73 PEX10 PEX12 PEX13 PEX14 PEX2 UBE2V2 VIMP UBE2B TMEM129 HLA-A HIST1H2BN HIST1H2BM HIST1H2BO HIST1H2BJ CTR9 VCP RNF152 HIST1H2BI RTF1 SHPRH HIST1H2BL HIST1H2BK DERL1 PAF1 PCNA IL-6-TYPE CYTOKINE RECEPTOR LIGAND INTERACTIONS%REACTOME%R-HSA-6788467.3 IL-6-type cytokine receptor ligand interactions IL11 CNTFR CNTF IL31 CTF1 IL11RA LIF OSM IL31RA LIFR TYK2 OSMR CLCF1 JAK2 IL6ST CRLF1 JAK1 DEFECTIVE SLC34A2 CAUSES PULMONARY ALVEOLAR MICROLITHIASIS (PALM)%REACTOME%R-HSA-5687583.1 Defective SLC34A2 causes pulmonary alveolar microlithiasis (PALM) SLC34A2 VITAMINS B6 ACTIVATION TO PYRIDOXAL PHOSPHATE%REACTOME%R-HSA-964975.1 Vitamins B6 activation to pyridoxal phosphate PDXK PNPO AOX1 FOXO-MEDIATED TRANSCRIPTION OF OXIDATIVE STRESS, METABOLIC AND NEURONAL GENES%REACTOME%R-HSA-9615017.1 FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes AGRP NR3C1 FOXO3 SIRT3 PCK1 INS SMAD2 SOD2 SMAD3 GCK SIN3A POMC FOXO6 FOXO4 PPARGC1A G6PC SMAD4 HDAC2 IGFBP1 SREBF1 TRIM63 HDAC1 CAT RETN FOXO1 ATXN3 NPY PLXNA4 ABCA6 FBXO32 LAMININ INTERACTIONS%REACTOME DATABASE ID RELEASE 72%3000157 Laminin interactions LAMA5 LAMA2 NID1 LAMA1 LAMA4 NID2 ITGB4 LAMA3 COL18A1 LAMB3 LAMB2 LAMB1 ITGA6 ITGB1 LAMC3 ITGA1 HSPG2 LAMC2 LAMC1 ITGAV ITGA3 ITGA2 ITGA7 OLFACTORY SIGNALING PATHWAY%REACTOME%R-HSA-381753.2 Olfactory Signaling Pathway GNB1 GNGT1 OR11H2 OR11H1 OR2M7 OR11H4 OR2M5 OR2M4 OR2M3 OR1K1 OR2M2 OR4K17 OR4Q3 OR2AE1 OR11H6 OR2L8 OR1J4 OR11G2 OR2L5 OR1J2 OR2L3 OR1J1 OR2L2 OR4P4 OR10AD1 OR5R1 OR6T1 OR4K15 OR4K14 OR4K13 OR13J1 OR1I1 OR2K2 OR6S1 OR5M11 OR5M10 OR10D3 OR8B12 OR14K1 OR2J3 OR4N5 OR2J2 OR4N4 OR2J1 OR4N2 OR5P3 OR5P2 OR10C1 OR10J1 OR11L1 OR10J3 OR10J5 OR5W2 OR6Y1 OR52B2 OR52B6 OR1N2 OR1N1 OR5V1 OR6X1 OR52A1 OR52A5 OR10H1 OR10H3 OR10H2 OR10H5 OR10H4 OR1M1 OR4S2 GNAL OR4S1 OR2AG1 OR2AG2 OR10G2 OR14A16 OR1L8 OR10G4 OR1L6 OR10G3 OR1L4 OR1L3 OR1L1 OR5T3 OR5T2 OR5T1 OR6V1 OR10G6 OR10G8 OR10G7 OR10G9 OR52W1 OR1S2 OR1S1 OR13D1 OR14C36 OR5AS1 OR2T8 OR2T7 OR2T6 OR2T5 OR2T4 OR2T3 OR2T2 OR13C9 OR2T1 OR13C8 OR4X2 OR2L13 OR4X1 OR9A4 OR51T1 OR9A2 OR13C3 OR13C2 OR13C5 OR13C4 OR5AR1 OR2S2 OR1Q1 OR51S1 OR4A47 OR5B21 REEP1 REEP5 REEP4 REEP3 REEP2 REEP6 OR13A1 OR7E24 OR7A10 OR14J1 OR13H1 OR2Y1 OR56B1 OR8D4 OR8D2 OR56B4 OR8D1 OR7A17 OR6C70 OR6C76 OR6C75 OR6C74 OR13G1 OR14I1 OR10A7 OR56A5 OR7A5 OR10A2 OR10A4 OR56A4 OR10A3 OR56A3 OR10A6 OR10A5 OR56A1 OR6C65 OR2W3 OR8B8 OR2W1 OR8B4 OR8B3 OR6C68 OR13F1 OR8B2 OR12D3 OR12D2 OR5AU1 OR51V1 OR2V2 OR2V1 OR11A1 OR8A1 OR7G2 OR8I2 OR7G1 OR9K2 OR52N1 OR52N5 OR52N4 OR52N2 OR51L1 OR5D18 OR10W1 OR2A42 OR5D16 OR5B3 OR5B2 OR5D14 OR8H3 OR5D13 OR8H2 OR8H1 OR52M1 OR10V1 OR4C12 OR2AT4 OR6C6 OR4C11 OR6C4 OR5A2 OR8G5 OR6C3 OR4C16 OR5AK2 OR5A1 OR6C2 OR4C15 OR6C1 OR4C13 OR8G1 OR9I1 OR10T2 OR51J1 OR52L1 OR7D4 OR6B3 OR6B2 OR6B1 OR7D2 OR2A25 OR51I2 OR10S1 OR52K2 OR51I1 OR52K1 OR4D11 OR2Z1 OR4D10 OR2A12 OR6A2 OR9G4 OR7C2 OR7C1 OR9G1 OR2A14 OR2A1 OR4E2 OR51Q1 OR4D9 OR5AP2 OR5B12 OR4D6 OR4D5 OR5B17 OR4D2 OR4D1 OR5F1 OR10Z1 OR52R1 OR4C6 OR4C5 OR3A3 OR3A2 OR4A15 OR4C3 OR14A2 OR3A1 OR4A16 OR8K5 OR8K3 OR8K1 OR5AN1 OR4B1 OR4C46 OR8J3 OR6F1 OR8J1 OR51M1 OR10X1 OR4A5 OR7G3 OR5C1 OR1C1 OR5K4 OR5K3 OR5K2 OR51D1 OR5K1 OR6M1 OR2T12 OR2T10 OR2T11 OR5H15 OR5H14 OR2D3 OR2D2 OR1B1 OR52E4 OR5J2 OR52E2 OR5AC2 OR52E8 OR52E6 OR52E5 OR2C3 OR1A2 OR6K6 OR1A1 OR2C1 OR51B2 OR6K3 OR6K2 OR5I1 OR52D1 OR9Q2 OR9Q1 OR2AK2 OR51B6 OR51B5 OR51B4 OR2B6 OR4F6 OR4F5 OR5H6 OR2B3 OR10K2 OR4F4 OR2B2 OR10K1 OR4F3 OR5H2 OR5H1 OR6J1 OR2AJ1 OR51A4 OR2A7 OR51A2 OR2A5 OR2A4 OR51A7 OR2A2 RTP4 RTP5 OR52J3 RTP2 OR51H1 RTP3 RTP1 OR1G1 OR4M2 OR4M1 OR10R2 OR10AG1 OR6Q1 OR8U1 OR51G2 OR52I2 OR51G1 OR52I1 OR1F1 OR2H2 OR2H1 OR4L1 OR10Q1 OR6P1 OR2B11 OR2AP1 OR51F2 OR2G6 OR51F1 OR5M9 OR52H1 OR5M8 OR2G3 OR1E2 OR4K5 OR2G2 OR1E1 OR5M3 OR4K2 OR4K1 OR5M1 OR10P1 OR2T34 OR8S1 OR2T35 OR2T33 OR4F29 OR4F21 OR1D5 OR2T27 OR51E1 OR1D2 OR2F2 OR2F1 OR2T29 OR51E2 OR5L2 OR6N2 OR5L1 OR6N1 OR4F17 OR4F16 OR4F15 CHK1 CHK2(CDS1) MEDIATED INACTIVATION OF CYCLIN B:CDK1 COMPLEX%REACTOME DATABASE ID RELEASE 72%75035 Chk1 Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex CDC25C YWHAG YWHAZ YWHAH CCNB1 CDK1 YWHAB YWHAE SFN CHEK2 CHEK1 YWHAQ WEE1 PLATELET DEGRANULATION%REACTOME%R-HSA-114608.3 Platelet degranulation ECM1 OLA1 CTSW SERPINA4 TMSB4X TIMP3 ANXA5 TOR4A LY6G6F LHFPL2 PCYOX1L FAM49B FAM3C SOD1 TMX3 TIMP1 RARRES2 SCCPDH LGALS3BP WDR1 ACTN2 PLEK PHACTR2 SRGN MMRN1 ITIH4 ITIH3 CLEC3B APP PFN1 CDC37L1 PCDH7 SPARC SPP2 STXBP2 PPBP ORM1 SERPINE1 ALDOA ORM2 SELP APOA1 CD109 QSOX1 CAP1 RAB27B CALU CD63 PPIA IGF1 TF CD36 CLU TGFB2 TGFB3 ITGB3 CFD FIGF PSAP VEGFB VEGFC ALB PLG PDGFB IGF2 CFL1 ITGA2B APOOL GAS6 PROS1 F13A1 KNG1 VCL A2M FGB FGA FN1 VWF HGF FGG F5 LEFTY2 F8 TUBA4A SERPING1 HSPA5 PF4 A1BG CYB5R1 FLNA SERPINA3 ACTN1 SERPINA1 ABCC4 EGF AHSG TTN BRPF3 THBS1 TGFB1 APLP2 SCG3 LAMP2 ISLR HABP4 CHID1 SERPINF2 GTPBP2 SYTL4 SEPP1 TAGLN2 NHLRC2 TEX264 VEGFA CD9 ENDOD1 APOH VTI1B MANF MAGED2 TLN1 HRG ACTN4 FERMT3 DEFECTIVE B4GALT1 CAUSES B4GALT1-CDG (CDG-2D)%REACTOME%R-HSA-3656244.2 Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) LUM KERA FMOD PRELP OMD OGN B4GALT1 NIK-->NONCANONICAL NF-KB SIGNALING%REACTOME%R-HSA-5676590.1 NIK-->noncanonical NF-kB signaling PSMD3 CUL1 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 UBA3 UBA52 PSMD10 PSMB11 MAP3K14 PSMD12 UBE2M PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 RELB PSMB7 PSMB4 PSMB5 PSMB2 UBB PSMB3 UBC PSMB1 PSMF1 RPS27A SHFM1 PSMB8 PSMB9 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 CHUK NFKB2 FBXW11 BTRC SKP1 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 SIGNAL ATTENUATION%REACTOME DATABASE ID RELEASE 72%74749 Signal attenuation SHC1 SOS1 IRS1 MAPK1 INS GRB10 IRS2 MAPK3 INSR REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR%REACTOME DATABASE ID RELEASE 72%1234158 Regulation of gene expression by Hypoxia-inducible Factor EPO EP300 CITED2 ARNT VEGFA HIF3A EPAS1 CREBBP CA9 HIGD1A HIF1A HOMOLOGY DIRECTED REPAIR%REACTOME%R-HSA-5693538.2 Homology Directed Repair EXO1 WHSC1 POLK RPA1 POLE RPA2 POLH POLD3 TOPBP1 RFC1 POLD4 WRN RPA3 POLD1 POLD2 DNA2 RFC5 SPIDR RFC3 RFC4 RFC2 RNF8 RNF4 CCNA2 CCNA1 POLQ RAD52 POLE4 RAD51 RBBP8 BRE ERCC4 ERCC1 POLE2 HIST3H3 POLE3 MDC1 KAT5 RAD50 CHEK1 HUS1 RHNO1 BRIP1 ATRIP BARD1 RAD17 ATM UBE2I ATR BRCA1 SUMO1 SUMO2 HERC2 PPP4R2 RTEL1 TIPIN RMI2 RMI1 TOP3A RAD51D PIAS4 UBA52 BRCC3 PPP4C TP53BP1 HIST3H2BB XRCC2 XRCC3 MRE11A XRCC1 HIST1H2BF HIST1H2BE HIST1H2BH HIST1H2BG HIST1H2BB HIST1H2BA HIST1H2BD HIST1H2BC BRCA2 UBB RAD1 BABAM1 UIMC1 UBC PARP1 PARP2 SIRT6 RPS27A RAD51B RNF168 RAD51C NBN HIST1H4K HIST1H4L SLX4 H2BFS HIST1H4A HIST1H4B HIST1H4H HIST1H4I HIST1H4J HIST1H4C HIST1H4D HIST1H4E UBE2N HIST1H4F EME1 EME2 GEN1 SLX1B LIG3 TIMELESS UBE2V2 SLX1A H2AFX RAD51AP1 ABL1 HIST2H2BE CLSPN HIST4H4 CDK2 PALB2 HIST1H2BN HIST1H2BM RAD9B HIST1H2BO RAD9A HIST1H2BJ FAM175A HIST1H2BI HIST1H2BL HIST1H2BK MUS81 HIST2H4A FEN1 BLM HIST2H4B PCNA GSD IV%REACTOME DATABASE ID RELEASE 72%3878781 GSD IV GBE1 GYS2 GYG2 WNT5A-DEPENDENT INTERNALIZATION OF FZD4%REACTOME%R-HSA-5099900.1 WNT5A-dependent internalization of FZD4 DVL2 PRKCA WNT5A PRKCG CLTC ARRB2 CLTB CLTA AP2A1 AP2B1 AP2A2 AP2S1 FZD4 AP2M1 PRKCB CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION%REACTOME%R-HSA-983169.3 Class I MHC mediated antigen processing & presentation BTBD1 CUL1 LONRF1 UBE2F UBE2H KLHL25 PDIA3 ZBTB16 GLMN KLHL21 KLHL22 UBE2A BTBD6 FBXO30 KLHL20 FBXO31 UBE2W CANX UBOX5 UBE2S CALR UBE2U RNF182 UBE2O TPP2 BLMH CDC20 UBA1 UBE2K TRIM71 RNF14 KBTBD13 SNAP23 UFL1 UBE2Q1 UBE2Q2 RNF34 TRIM69 ZNF645 UNKL DTX3L ITCH PJA2 PJA1 TRAF7 UBE2R2 THOP1 TRIM50 MGRN1 VAMP8 TIRAP VPRBP TLR1 ASB13 ASB14 CTSV TLR6 ASB11 TLR2 RNF6 CTSS RNF7 CTSL ASB12 ASB17 ASB18 FBXL22 RNF213 ASB15 ASB16 FBXL20 ZNRF1 STX4 ZNRF2 HECTD1 HECTD2 ASB10 HECTD3 RBBP6 TRIM41 RNF25 FBXL19 ITGB5 FBXL15 FBXL16 FBXL13 LNPEP FBXL14 SEC61A2 FZR1 FBXL12 SEC61A1 TRIM39 SEC61G ASB8 SEC61B ASB9 VAMP3 LNX1 ASB6 ASB7 TRIM36 TRIM37 ASB4 ASB5 ASB2 ASB1 FBXW11 CUL3 SOCS1 KBTBD7 FCGR1A HERC2 RNF111 RNF41 IKBKG VHL ANAPC7 UBE2C FBXO4 UBE2E1 FBXO6 UBE2D1 ANAPC10 ANAPC11 SOCS3 CDC23 CDC26 CDC34 FBXW4 CDC27 FBXW5 CDC16 FBXW10 FBXW7 FBXW9 ANAPC4 ANAPC5 FBXW2 ANAPC1 ANAPC2 UBE2D2 SKP2 UBE2D3 CUL2 FBXL3 FBXL5 NEDD4L CUL7 UBE2V2 SEC23A SMURF1 TRIM21 UBE2B TRIM63 UBR4 FBXO32 TRIM32 SEC24B SEC24A SEC24D RNF4 SEC24C UBA3 RCHY1 WWP1 UBE2M SAR1B SEC13 STUB1 IKBKB CHUK MKRN1 KCTD6 UBE2V1 HUWE1 CD36 MYD88 FBXL7 NCF1 NCF2 HLA-A NCF4 B2M FBXL18 PSMD8 PSMD9 PSMD6 LY96 PSMD7 ITGAV PSMD4 CD14 PSMD5 TLR4 PSMD2 PSMD3 PSMD1 CYBB CYBA FCGR1B PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 UBA52 TCEB2 PSMD10 TCEB1 PSMB11 MRC2 PSMD12 MRC1 CD207 PSMD11 PSMD14 PSMD13 PSMA7 LRR1 PSMB10 CCNF PSMA8 KEAP1 ATG7 CBLB UBE2L3 PSMB6 HERC4 HERC3 PSMB7 SMURF2 RNF115 RNF114 PSMB4 UBE2L6 HERC1 FBXO7 PSMB5 FBXO9 PSMB2 HERC5 HERC6 UBB WSB1 PSMB3 FBXO2 RNF123 RNF126 UBC HECW2 PSMB1 TRIM11 PSMF1 ANAPC13 UBE2J2 RPS27A UBE2J1 RNF217 HACE1 SIAH2 HSPA5 SHFM1 SIAH1 ERAP2 MEX3C PSMB8 ERAP1 HLA-B UBAC1 PSMB9 FBXL8 PSMC5 TAP2 HLA-C FBXL4 PSMC6 DZIP3 PSMC3 TAP1 HLA-F RNF220 PSMC4 UBA7 HLA-G DET1 PSMC1 HLA-E LRSAM1 PSMC2 SH3RF1 TAPBP SEC31A TRIM9 TRIM4 ARIH2 GPR75-ASB3 LRRC41 RNF144B GAN NEDD4 RNF138 UBE2N RNF130 KLHL2 KLHL3 UBE2G1 UBE2G2 KLHL9 SPSB2 SPSB1 KBTBD6 KLHL5 RLIM TRIP12 KBTBD8 SPSB4 UBE2D4 UBE3C UBE3D MYLIP FBXO27 LTN1 RNF19B UBE3A UBE3B FBXO21 UBE2Z FBXO22 PARK2 NPEPPS RNF19A FBXW12 AREL1 FBXW8 UBE2E3 FBXO17 UBE2E2 FBXO15 MIB2 UBE4A LMO7 FBXO10 FBXO11 KLHL41 TRAIP KLHL42 BTRC RBCK1 KCTD7 SKP1 CUL5 BTK UBA6 UBA5 RBX1 KLHL11 SEC22B UBR2 KLHL13 UBR1 FBXO44 FBXO41 FBXO40 RECOGNITION AND ASSOCIATION OF DNA GLYCOSYLASE WITH SITE CONTAINING AN AFFECTED PYRIMIDINE%REACTOME DATABASE ID RELEASE 72%110328 Recognition and association of DNA glycosylase with site containing an affected pyrimidine TDG TINF2 NEIL3 TERF2IP NEIL2 NEIL1 HIST1H2AE NTHL1 HIST1H2AD HIST3H2BB HIST1H2AC ACD HIST1H2AB HIST1H2AJ HIST1H2BF HIST1H2BE SMUG1 HIST1H2BH HIST1H2BG HIST1H2BB HIST1H2BA HIST1H2BD OGG1 HIST1H2BC H2AFB1 HIST3H3 TERF1 TERF2 POT1 HIST1H4K HIST1H4L H2BFS HIST1H4A MBD4 HIST1H4B HIST1H4H HIST1H4I HIST1H4J HIST1H4C HIST1H4D HIST1H4E HIST1H4F HIST2H2AA3 HIST2H2AA4 HIST2H2AC H2AFJ H2AFZ H2AFX H2AFV HIST2H2BE HIST4H4 HIST1H2BN HIST1H2BM HIST1H2BO HIST1H2BJ HIST1H2BI HIST1H2BL HIST1H2BK HIST2H4A HIST2H4B RORA ACTIVATES GENE EXPRESSION%REACTOME DATABASE ID RELEASE 72%1368082 RORA activates gene expression NCOA6 EP300 TBL1X RXRA PPARA CHD9 RORA TGS1 MED1 HELZ2 SREBF1 TBL1XR1 SMARCD3 CARM1 NCOA1 CPT1A NCOA2 CREBBP EXTRA-NUCLEAR ESTROGEN SIGNALING%REACTOME DATABASE ID RELEASE 72%9009391 Extra-nuclear estrogen signaling PDPK1 AKT1 SPHK1 ESR2 STRN PRMT1 S1PR3 PIK3R2 ELK1 NOS3 CAV1 GNAT3 PIK3R3 PTK2 FOS CCND1 CREB1 ZDHHC21 SRF GNG10 MAPK1 MAPK3 MMP2 GNG12 MMP3 GNG11 GNG13 GNB2 FOXO3 UHMK1 GNB1 BCL2 GNB4 GNB3 GNB5 ESR1 EGF GNGT1 PIK3R1 GNGT2 EGFR PIK3CA HSP90AA1 ZDHHC7 HRAS GNAI3 IGF1R GNAI1 GNAI2 CAV2 BTC PRKCZ GNG3 EPGN TGFA GNG2 AREG NRAS GNG5 HBEGF GNG4 EREG GNG7 GNG8 CDKN1B AKT2 AKT3 XPO1 SRC MMP7 MMP9 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%R-HSA-1368108.4 BMAL1:CLOCK,NPAS2 activates circadian gene expression ARNTL TBL1X AVP TGS1 HELZ2 TBL1XR1 SMARCD3 NCOA1 CLOCK NCOA2 CREBBP NCOA6 NPAS2 NAMPT RXRA PPARA CHD9 BHLHE41 DBP CCRN4L MED1 KLF15 F7 SERPINE1 ARNTL2 CARM1 BHLHE40 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION%REACTOME DATABASE ID RELEASE 72%69202 Cyclin E associated events during G1 S transition PSMD3 RBBP4 AKT1 CUL1 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 CCNH PSME1 RBL2 PSME2 CCNA2 CCNA1 UBA52 TFDP1 PSMD10 TFDP2 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMB6 PSMB7 E2F1 PSMB4 E2F4 PSMB5 PSMB2 UBB PSMB3 CCND1 UBC PSMB1 PSMF1 RPS27A RB1 SHFM1 MYC PSMB8 PSMB9 SKP2 PSMC5 CDC25A PSMC6 MAX PSMC3 PSMC4 PSMC1 CDK7 PSMC2 CCNE2 MNAT1 CCNE1 LIN54 CKS1B LIN52 PTK6 CDK4 LIN37 LIN9 E2F5 CABLES1 WEE1 CDK2 CDKN1A CDKN1B AKT2 SKP1 PSMD8 AKT3 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 FIBRONECTIN MATRIX FORMATION%REACTOME%R-HSA-1566977.1 Fibronectin matrix formation CEACAM1 ITGB1 CEACAM6 CEACAM8 FN1 ITGA5 PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR%REACTOME DATABASE ID RELEASE 72%392851 Prostacyclin signalling through prostacyclin receptor GNG11 PTGIR GNG13 GNB2 GNB1 GNB4 GNB3 GNG3 GNAS GNG2 GNG5 GNB5 GNG4 GNG7 GNG8 GNGT1 GNGT2 GNG10 GNG12 G1 PHASE%REACTOME DATABASE ID RELEASE 72%69236 G1 Phase PPP2CA CUL1 PPP2CB CDK7 LYN E2F2 E2F3 MNAT1 CKS1B CCND3 CCNH CCND2 JAK2 CDK6 RBL2 PTK6 UBA52 TFDP1 RBL1 CDK4 PPP2R1B TFDP2 PPP2R1A PPP2R2A E2F5 CDKN1C CDKN2A PPP2R3B ABL1 E2F1 E2F4 UBB CDKN1A CCND1 UBC CDKN1B RPS27A SKP1 RB1 CDKN2D SKP2 CDKN2B CDKN2C HCMV LATE EVENTS%REACTOME%R-HSA-9610379.1 HCMV Late Events HIST2H2AB NUP107 NUP188 HIST2H2BF NUP62 NDC1 NUP214 SEC13 CEBPD NUP133 NUP210 HIST3H2A NUP93 NUP50 NUP54 HIST1H2AG HIST1H2AA HIST1H2AM HIST1H2AL HIST1H2AI HIST1H2AH POM121 HIST1H2AK NUP205 AAAS NUP160 NUP85 TPR NUP88 NUP43 HNRNPK RAE1 RANBP2 CHMP2A NUP155 NUP153 NUP35 NUPL2 NUP37 TSG101 VPS4A MVB12B MVB12A VPS36 VPS37C VPS37D VPS37A SNF8 VPS37B CHMP2B CHMP4C UBAP1 CHMP4B CHMP3 CHMP4A HIST1H2AE CHMP6 HIST1H2AD VPS25 HIST3H2BB HIST1H2AC CHMP7 HIST1H2AB VPS28 HIST1H2AJ HIST2H3A HIST1H2BF HIST1H2BE HIST1H2BH HIST1H2BG HIST2H3D HIST1H2BB HIST1H2BA CHMP1A HIST2H3C HIST1H2BD HIST1H2BC HIST1H3J HIST1H3A HIST1H3F HIST1H3G HIST1H3H HIST1H3I HIST1H3B HIST1H3C HIST1H3D HIST1H3E HIST1H4K HIST1H4L HIST1H4A HIST1H4B HIST1H4H HIST1H4I HIST1H4J HIST1H4C HIST1H4D HIST1H4E HIST1H4F HIST2H2AA3 HIST2H2AA4 HIST2H2AC HIST2H2BE HIST4H4 HIST1H2BN HIST1H2BM HIST1H2BO HIST1H2BJ HIST1H2BI HIST1H2BL HIST1H2BK HIST2H4A HIST2H4B MMR%REACTOME DATABASE ID RELEASE 72%5358508 MMR LIG1 EXO1 RPA1 MLH1 RPA2 POLD3 POLD4 MSH2 RPA3 POLD1 POLD2 PMS2 MSH6 MSH3 PCNA AMINE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 72%375280 Amine ligand-binding receptors DRD1 DRD5 HTR6 HTR7 DRD2 HTR1E DRD3 HTR1F DRD4 HTR1D HTR2B HTR1A HTR1B ADRA2C HTR2C HTR2A ADRA2A CHRM3 HTR4 HTR5A ADRA1D ADRA1B ADRA1A HRH1 ADRB3 HRH3 TAAR8 HRH4 TAAR9 GPR143 TAAR6 TAAR5 CHRM1 TAAR2 TAAR1 CHRM2 CHRM4 CHRM5 ADRB1 ADRB2 HRH2 NUCLEOBASE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 72%8956320 Nucleobase biosynthesis PAICS CAD PFAS IMPDH1 IMPDH2 LHPP GART DHODH ATIC ADSSL1 ADSS ADSL PPAT GMPS UMPS KSRP (KHSRP) BINDS AND DESTABILIZES MRNA%REACTOME DATABASE ID RELEASE 72%450604 KSRP (KHSRP) binds and destabilizes mRNA AKT1 EXOSC7 DIS3 MAPK14 EXOSC6 MAPK11 YWHAZ EXOSC5 EXOSC4 EXOSC9 EXOSC8 EXOSC3 EXOSC2 DCP2 EXOSC1 PARN KHSRP FORMATION OF ANNULAR GAP JUNCTIONS%REACTOME%R-HSA-196025.2 Formation of annular gap junctions CLTB GJA1 CLTA CLTCL1 DNM1 AP2M1 DAB2 CLTC DNM2 CELLULAR SENESCENCE%REACTOME DATABASE ID RELEASE 72%2559583 Cellular Senescence CCNA2 CCNA1 TFDP1 TFDP2 E2F1 BMI1 RNF2 CBX8 PHC2 PHC1 RING1 CBX4 CBX2 TNRC6C PHC3 RAD50 TNRC6A TNRC6B LMNB1 FZR1 E2F2 E2F3 IL6 TINF2 IL1A EHMT2 HIST1H1D HIST1H1E HIST1H2AE HIST1H2AD HIST3H2BB HIST1H1A ACD HIST1H2AC HIST1H1B HIST1H2AB HIST1H1C HIST1H2AJ HIST2H3A HIST1H2BF HIST1H2BE ANAPC15 HIST1H2BH ANAPC16 HIST1H2BG HIST2H3D ANAPC7 ASF1A HIST1H2BB UBE2C HIST1H2BA HIST2H3C UBE2E1 UBE2D1 HIST1H2BD ANAPC10 HIST1H2BC ANAPC11 H2AFB1 H1F0 CDC23 HIST1H3J CDC26 CDC27 HIST1H3A HIST1H3F CDC16 HIST1H3G HIST1H3H ANAPC4 HIST1H3I ANAPC5 TERF1 ANAPC1 HIST1H3B TERF2 ANAPC2 HIST1H3C HIST1H3D RB1 HIST1H3E H3F3B HIST1H4K POT1 UBN1 CDKN2D HIST1H4L CDKN2B H3F3A CDKN2C H2BFS HIST1H4A HIST1H4B MAP3K5 HIST1H4H ERF HIST1H4I TNIK HIST1H4J HIST1H4C HIST1H4D HIST1H4E EZH2 IGFBP7 HIST1H4F HIST2H2AA3 HIST2H2AA4 HIST2H2AC H2AFJ CEBPB EED H2AFZ H2AFX H2AFV HIST2H2BE HIST4H4 VENTX MINK1 HIST1H2BN HIST1H2BM HIST1H2BO HIRA HIST1H2BJ MAP4K4 STAT3 IFNB1 HIST1H2BI ETS1 HIST1H2BL ETS2 HIST1H2BK HIST2H4A HIST2H4B CBX6 RBBP4 HMGA2 CXCL8 CABIN1 TERF2IP RBBP7 SUZ12 HMGA1 MAPK8 RELA HIST3H3 EHMT1 KAT5 MAP2K3 MAP2K4 TP53 EP400 TXN NFKB1 MAPK9 CDK4 MAP2K7 MAPK10 JUN MOV10 AGO3 KDM6B AGO4 AGO1 ATM CDKN1A CDKN1B MAPKAPK3 CDK6 UBA52 CDKN2A RPS6KA3 MRE11A RPS6KA2 RPS6KA1 FOS UBB UBC RPS27A MAPKAPK2 SP1 NBN MAPK7 MAPK1 MAPK3 MAPK14 CCNE2 MAPK11 CCNE1 ID1 MAPKAPK5 MAP2K6 CDK2 MDM2 MDM4 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION%REACTOME%R-HSA-156827.3 L13a-mediated translational silencing of Ceruloplasmin expression RPL26 RPL29 RPL10L RPS4X RPL10A RPL28 RPS3A RPL23A FAU RPL41 RPL3L RPL10 RPL12 RPL13A RPL11 RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL27A RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS15 RPS14 RPS17 RPS16 RPS19 RPL18A RPL36AL RPS18 RPLP1 RPS11 RPS10 RPLP0 RPS13 RPS12 RPLP2 RPL7A RPS27L PABPC1 UBA52 RPL37A RPS26 RPS25 RPS28 EIF1AX RPS27 RPL36A RPS29 EIF2S2 RPS20 RPL35A EIF2S1 RPS21 RPS24 EIF2S3 RPS23 EIF4A2 EIF4H EIF4A1 EIF3M EIF3K EIF3L RPL22L1 EIF3I EIF3J EIF3G EIF3H EIF3E EIF3F EIF3C EIF3D EIF3A RPS4Y2 EIF3B RPS4Y1 RPS27A EIF4G1 EIF4E RPL26L1 RPL4 RPL39L RPL5 RPL30 RPL3 RPL32 RPL31 EIF4B RPL34 RPL8 RPL9 RPL6 RPL7 RPL36 RPL35 RPL38 RPL37 RPL39 RPS15A RPL21 RPL23 RPL22 RPL24 RPL27 ALPHA-LINOLENIC ACID (ALA) METABOLISM%REACTOME%R-HSA-2046106.1 alpha-linolenic acid (ALA) metabolism ACOT8 ELOVL5 ELOVL2 ELOVL3 FADS2 ACSL1 ACAA1 ABCD1 ELOVL1 SCP2 FADS1 HSD17B4 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A%REACTOME DATABASE ID RELEASE 72%69601 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 UBA52 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 UBB PSMB3 UBC PSMB1 PSMF1 RPS27A CHEK2 SHFM1 CHEK1 PSMB8 PSMB9 PSMC5 CDC25A PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 DEFECTIVE SLC35A1 CAUSES CONGENITAL DISORDER OF GLYCOSYLATION 2F (CDG2F)%REACTOME%R-HSA-5663020.1 Defective SLC35A1 causes congenital disorder of glycosylation 2F (CDG2F) SLC35A1 SIGNALING BY FGFR3%REACTOME%R-HSA-5654741.2 Signaling by FGFR3 PPP2CA PPP2CB BRAF FRS2 PTPN11 SPRY2 FRS3 FGF16 FGF18 GAB1 PIK3R1 CBL UBA52 PIK3CA FGF9 PLCG1 SOS1 PPP2R1A FGF20 FGF1 FGF2 FGF23 MKNK1 FGF4 HRAS NRAS UBB GALNT3 UBC RPS27A MAPK1 MAPK3 GLYCOSAMINOGLYCAN METABOLISM%REACTOME%R-HSA-1630316.2 Glycosaminoglycan metabolism SDC4 SDC2 HS2ST1 SDC3 CHST11 CHST12 NDST2 CSGALNACT1 NDST1 CHST15 CHST13 LYVE1 NDST4 CSGALNACT2 NDST3 KERA EXT1 EXT2 SLC26A2 SLC26A1 HMMR CHSY1 SDC1 CHSY3 LUM B4GALT2 B4GALT3 B4GALT1 SGSH CHPF2 HSPG2 B4GAT1 GUSB ARSB ABCC5 HS3ST3A1 B4GALT6 B4GALT7 B4GALT4 B4GALT5 FMOD HYAL1 CHST6 PRELP CHPF HYAL2 CHST7 HYAL3 B3GAT3 B3GAT2 NAGLU IDS B3GAT1 CHP1 SLC35B3 SLC35B2 CD44 HS6ST1 HS6ST2 CHST1 HS6ST3 CEMIP GPC1 GPC3 CHST5 GPC2 GPC5 CHST2 GPC4 GPC6 CHST3 HEXB HEXA AGRN GLB1L SLC35D2 IDUA HAS1 HS3ST5 HAS3 HS3ST6 HAS2 HS3ST4 HS3ST1 HS3ST2 XYLT2 XYLT1 HPSE2 HS3ST3B1 GNS OGN SLC9A1 HPSE ST3GAL4 ST3GAL6 B3GALT6 ST3GAL1 ST3GAL2 ST3GAL3 GLB1 STAB2 PAPSS2 PAPSS1 BCAN VCAN DSEL NCAN UST DSE GLCE BGN CSPG5 CSPG4 CHST14 DCN OMD B3GNT7 B3GNT4 B3GNT3 B3GNT2 EVASION OF ONCOGENE INDUCED SENESCENCE DUE TO DEFECTIVE P16INK4A BINDING TO CDK4 AND CDK6%REACTOME DATABASE ID RELEASE 72%9630794 Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 CDK6 CDK4 CDKN2A INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION%REACTOME DATABASE ID RELEASE 72%400508 Incretin synthesis, secretion, and inactivation GIP GRP GNG13 GPR119 PCSK1 DPP4 GNAT3 SEC11A SEC11C TCF7L2 GNB3 CDX2 FFAR4 LEP CTNNB1 FFAR1 PAX6 GATA4 ISL1 SPCS3 SPCS2 SPCS1 GCG SIGNALING BY TGF-BETA RECEPTOR COMPLEX%REACTOME%R-HSA-170834.1 Signaling by TGF-beta Receptor Complex RNF111 PPP1CC MEN1 CCNC SMAD2 UBA52 SMAD3 TFDP1 RBL1 TFDP2 UBE2M JUNB SMURF2 E2F4 UBE2D1 UBB CCNK PARP1 UBC CCNT2 SERPINE1 CCNT1 SKIL STUB1 TGIF1 RPS27A TGIF2 USP9X SP1 ATP1B4 SKI TRIM33 MYC UBE2D3 CDKN2B PMEPA1 NEDD8 BAMBI STRAP MTMR4 SNW1 NEDD4L CBL PPP1R15A PPP1CB SMAD7 WWTR1 UCHL5 E2F5 USP15 NCOR2 PPM1A CDK9 NCOR1 TGFB1 SMAD4 SMURF1 ARHGEF18 CGN F11R PRKCZ TGFBR1 RHOA TGFBR2 FKBP1A PARD6A PARD3 HDAC1 XPO1 FURIN PPP1CA CDK8 RECOGNITION AND ASSOCIATION OF DNA GLYCOSYLASE WITH SITE CONTAINING AN AFFECTED PURINE%REACTOME%R-HSA-110330.3 Recognition and association of DNA glycosylase with site containing an affected purine TINF2 NEIL3 TERF2IP HIST1H2AE HIST1H2AD HIST3H2BB HIST1H2AC ACD HIST1H2AB HIST1H2AJ HIST1H2BF HIST1H2BE HIST1H2BH HIST1H2BG HIST1H2BB HIST1H2BA HIST1H2BD OGG1 HIST1H2BC H2AFB1 HIST3H3 TERF1 TERF2 POT1 HIST1H4K HIST1H4L H2BFS HIST1H4A HIST1H4B HIST1H4H HIST1H4I HIST1H4J HIST1H4C HIST1H4D HIST1H4E MPG HIST1H4F HIST2H2AA3 HIST2H2AA4 HIST2H2AC H2AFJ H2AFZ H2AFX H2AFV HIST2H2BE HIST4H4 HIST1H2BN HIST1H2BM HIST1H2BO HIST1H2BJ HIST1H2BI HIST1H2BL HIST1H2BK HIST2H4A HIST2H4B DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR)%REACTOME DATABASE ID RELEASE 72%1168372 Downstream signaling events of B Cell Receptor (BCR) PSMD3 CUL1 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 UBA52 PSMD10 PSMB11 PSMD12 RASGRP1 PSMD11 PSMD14 RASGRP3 NFKBIA IKBKG PSMD13 RELA PSMA7 PSMB10 PSMA8 NFKBIE PSMB6 PSMB7 NFATC2 PSMB4 PSMB5 PSMB2 UBB PSMB3 CARD11 UBC BCL10 PSMB1 PSMF1 RPS27A SHFM1 PSMB8 PSMB9 MALT1 PSMC5 PSMC6 PSMC3 PPP3R1 PSMC4 REL PSMC1 PSMC2 IKBKB CHUK PPIA NFKB1 NFKBIB HRAS FBXW11 PPP3CA PPP3CB NFATC3 NFATC1 NRAS FKBP1A BTRC SKP1 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 MAP3K7 PSMD5 PSMD2 PRKCB REMOVAL OF AMINOTERMINAL PROPEPTIDES FROM GAMMA-CARBOXYLATED PROTEINS%REACTOME%R-HSA-159782.3 Removal of aminoterminal propeptides from gamma-carboxylated proteins F7 GAS6 PROC F9 F10 PROS1 PROZ BGLAP FURIN F2 SHC-MEDIATED CASCADE:FGFR2%REACTOME%R-HSA-5654699.1 SHC-mediated cascade:FGFR2 HRAS FGF16 FGF7 FGF18 NRAS FGF6 FGF9 SOS1 FGF20 FGF1 FGF2 FGF23 FGF3 FGF22 FGF10 FGF4 METABOLISM OF VITAMIN K%REACTOME%R-HSA-6806664.3 Metabolism of vitamin K VKORC1L1 UBIAD1 VKORC1 DEFECTIVE TPMT CAUSES THIOPURINE S-METHYLTRANSFERASE DEFICIENCY (TPMT DEFICIENCY)%REACTOME DATABASE ID RELEASE 72%5578995 Defective TPMT causes Thiopurine S-methyltransferase deficiency (TPMT deficiency) TPMT SUPPRESSION OF PHAGOSOMAL MATURATION%REACTOME DATABASE ID RELEASE 72%9637687 Suppression of phagosomal maturation ATP6V1H UBB UBC KPNA1 RPS27A UBA52 HGS VPS33B KPNB1 RAB5A CORO1A RAB7A NOS2 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE%REACTOME%R-HSA-416572.2 Sema4D induced cell migration and growth-cone collapse SEMA4D RND1 MYL12B MYH9 LIMK2 LIMK1 RHOA MYH11 ROCK1 ROCK2 RHOC RHOB MYH14 MYH10 ARHGEF11 PLXNB1 ARHGEF12 MYL6 ERBB2 MYL9 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS%REACTOME%R-HSA-2691232.1 Constitutive Signaling by NOTCH1 HD Domain Mutants ADAM10 DLL1 DLL4 NEURL1B JAG2 ADAM17 UBB JAG1 MIB2 MIB1 UBC NEURL1 RPS27A UBA52 NOTCH1 LISTERIA MONOCYTOGENES ENTRY INTO HOST CELLS%REACTOME%R-HSA-8876384.1 Listeria monocytogenes entry into host cells SH3GL1 CDH1 SH3GL2 MET UBB CTNNB1 STAM UBC CTNND1 CBL RPS27A UBA52 HGS SH3GL3 SH3KBP1 STAM2 SRC CBLL1 EPS15 PEROXISOMAL PROTEIN IMPORT%REACTOME%R-HSA-9033241.3 Peroxisomal protein import ACOX2 ACOX3 ACOT4 ACAA1 NUDT19 SCP2 DECR2 GSTK1 DHRS4 UBA52 DDO SLC27A2 EPHX2 CROT GNPAT LONP2 BAAT UBE2D1 PECR UBB HSD17B4 UBC RPS27A PIPOX USP9X UBE2D2 UBE2D3 HACL1 NUDT7 ACOT2 ZFAND6 IDE PEX26 MPV17 ECH1 EHHADH PAOX HMGCL PEX1 PEX7 PEX6 AGXT PEX10 PEX12 PEX13 ACOX1 PEX14 TYSND1 PHYH PEX2 HAO1 NOS2 HAO2 AGPS IDH1 ACOT8 AMACR DAO CAT CRAT SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME DATABASE ID RELEASE 72%2660825 Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant ADAM10 DLL1 DLL4 JAG2 ADAM17 JAG1 NOTCH1 ACTIVATION OF NF-KAPPAB IN B CELLS%REACTOME DATABASE ID RELEASE 72%1169091 Activation of NF-kappaB in B cells PSMD3 CUL1 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 UBA52 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 NFKBIA IKBKG PSMD13 RELA PSMA7 PSMB10 PSMA8 NFKBIE PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 UBB PSMB3 CARD11 UBC BCL10 PSMB1 PSMF1 RPS27A SHFM1 PSMB8 PSMB9 MALT1 PSMC5 PSMC6 PSMC3 PSMC4 REL PSMC1 PSMC2 IKBKB CHUK NFKB1 NFKBIB FBXW11 BTRC SKP1 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 MAP3K7 PSMD5 PSMD2 PRKCB MET ACTIVATES STAT3%REACTOME%R-HSA-8875791.1 MET activates STAT3 STAT3 HGF MET HYALURONAN BIOSYNTHESIS AND EXPORT%REACTOME%R-HSA-2142850.2 Hyaluronan biosynthesis and export ABCC5 HAS1 CEMIP HAS3 HAS2 SYNTHESIS OF 15-EICOSATETRAENOIC ACID DERIVATIVES%REACTOME DATABASE ID RELEASE 72%2142770 Synthesis of 15-eicosatetraenoic acid derivatives PTGS2 ALOX15 GPX2 GPX1 ALOX15B GPX4 PHOSPHO-PLA2 PATHWAY%REACTOME%R-HSA-111995.1 phospho-PLA2 pathway PLA2G4A MAPK1 T41 MUTANTS OF BETA-CATENIN AREN'T PHOSPHORYLATED%REACTOME%R-HSA-5358752.1 T41 mutants of beta-catenin aren't phosphorylated CSNK1A1 PPP2CA PPP2CB PPP2R5B PPP2R5A PPP2R5D CTNNB1 GSK3B PPP2R5C PPP2R1B PPP2R1A AMER1 AXIN1 APC PPP2R5E TP53 REGULATES TRANSCRIPTION OF CELL CYCLE GENES%REACTOME DATABASE ID RELEASE 72%6791312 TP53 Regulates Transcription of Cell Cycle Genes TNKS1BP1 ZNF385A CNOT6L PRMT1 RBL2 PLAGL1 CCNA2 CCNA1 TFDP1 RBL1 TFDP2 NPM1 EP300 AURKA E2F1 E2F4 CENPJ E2F7 E2F8 CCNB1 CDK1 ARID3A CARM1 RQCD1 BAX CDC25C CCNE2 CCNE1 TP53 PCBP4 SFN PLK3 CNOT10 CNOT4 GADD45A CNOT6 PLK2 CNOT7 RGCC CNOT11 CNOT1 CNOT2 CNOT3 CDK2 CDKN1A BTG2 CDKN1B CNOT8 PCNA DEFECTIVE PRO-SFTPC CAUSES PULMONARY SURFACTANT METABOLISM DYSFUNCTION 2 (SMDP2) AND RESPIRATORY DISTRESS SYNDROME (RDS)%REACTOME%R-HSA-5688354.1 Defective pro-SFTPC causes pulmonary surfactant metabolism dysfunction 2 (SMDP2) and respiratory distress syndrome (RDS) SFTPC HDR THROUGH SINGLE STRAND ANNEALING (SSA)%REACTOME DATABASE ID RELEASE 72%5685938 HDR through Single Strand Annealing (SSA) EXO1 HUS1 RPA1 RPA2 TOPBP1 WRN RPA3 RMI2 RFC5 DNA2 RFC3 RMI1 RFC4 TOP3A RHNO1 RFC2 BRIP1 ATRIP BARD1 MRE11A RAD52 ABL1 RAD51 RBBP8 ERCC4 RAD17 ERCC1 ATM RAD1 ATR RAD9B RAD9A KAT5 RAD50 BRCA1 NBN BLM SUNITINIB-RESISTANT PDGFR MUTANTS%REACTOME%R-HSA-9674401.1 Sunitinib-resistant PDGFR mutants PDGFRA HUR (ELAVL1) BINDS AND STABILIZES MRNA%REACTOME%R-HSA-450520.2 HuR (ELAVL1) binds and stabilizes mRNA PRKCD PRKCA ELAVL1 SET TNFSF13 XPO1 ANP32A NUP214 TRANSCRIPTIONAL REGULATION BY RUNX3%REACTOME DATABASE ID RELEASE 72%8878159 Transcriptional regulation by RUNX3 PSMD3 PSMD1 BCL2L11 ITGAL PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 CBFB PSMA2 RUNX1 PSME3 PSME1 PSME2 UBA52 SMAD3 PSMD10 PSMD12 PSMD11 PSMD14 PSMD13 CDKN2A KRAS PSMA7 PSMB10 EP300 PSMB6 PSMB7 SMURF2 PSMB4 YAP1 PSMB5 PSMB2 UBB PSMB3 CTNNB1 CCND1 UBC PSMB1 PSMF1 BRD2 RPS27A SHFM1 MYC PSMB8 PSMB9 PSMC5 SPP1 PSMC6 PSMC3 NOTCH1 PSMC4 MAML2 PSMC1 PSMC2 MAML1 RBPJ FOXO3 TCF7 HES1 TCF7L2 TP53 SNW1 MAML3 MAMLD1 LEF1 TEAD4 ITGA4 TCF7L1 CTGF TEAD1 WWTR1 TEAD2 TEAD3 CREBBP HDAC4 ZFHX3 TGFB1 SMAD4 SMURF1 RUNX3 KAT2B KAT2A JAG1 MDM2 CDKN1A PSMD8 PSMD9 PSMD6 SRC PSMD7 PSMD4 PSMD5 PSMD2 METAL ION SLC TRANSPORTERS%REACTOME%R-HSA-425410.2 Metal ion SLC transporters SLC31A1 SLC39A10 SLC39A14 SLC39A6 SLC39A5 SLC39A8 SLC39A7 SLC39A2 SLC39A1 SLC39A4 SLC39A3 CP SLC11A1 SLC40A1 HEPH SLC30A7 SLC30A6 SLC30A8 SLC41A2 SLC30A3 SLC30A2 SLC41A1 SLC30A5 SLC30A10 SLC30A1 SLC11A2 RESISTANCE OF ERBB2 KD MUTANTS TO AEE788%REACTOME DATABASE ID RELEASE 72%9665250 Resistance of ERBB2 KD mutants to AEE788 ERBB2IP HSP90AA1 CDC37 ERBB2 TANDEM PORE DOMAIN HALOTHANE-INHIBITED K+ CHANNEL (THIK)%REACTOME DATABASE ID RELEASE 72%1299287 Tandem pore domain halothane-inhibited K+ channel (THIK) KCNK13 DEFECTIVE ALG3 CAUSES ALG3-CDG (CDG-1D)%REACTOME%R-HSA-4720475.1 Defective ALG3 causes ALG3-CDG (CDG-1d) ALG3 SIGNALING BY NTRK1 (TRKA)%REACTOME DATABASE ID RELEASE 72%187037 Signaling by NTRK1 (TRKA) RAPGEF1 MAP2K1 MAP2K2 DNM1 BRAF DNM3 PPP2R1B NTRK2 PPP2R1A RALA SH3GL2 RALGDS DNAL4 PPP2R5D RALB KIDINS220 RIT1 ADCYAP1 RIT2 ADCYAP1R1 NTRK1 PPP2CA PPP2CB MAP2K5 HRAS ADORA2A NRAS CLTC CLTA AP2A1 PIK3CB AP2B1 YWHAB AP2A2 AP2S1 AP2M1 NGF MAPKAPK3 CRK SHC2 PIK3R2 ATF1 SH3GL3 ATF2 NAB1 NAB2 CHD4 ELK1 RPS6KA3 LYL1 RPS6KA5 RPS6KA2 RPS6KA1 EP300 JUNB DUSP4 MEF2A MEF2C MAPK12 CRKL RAP1A DUSP3 MAPK13 TCF12 FOS IRS1 VRK3 F3 IRS2 DUSP6 DNM2 DUSP7 ARC CREB1 VGF MAPKAPK2 SGK1 TRIB1 TPH1 RRAD SRF ASCL1 MAPK7 SHC3 MAPK1 MEF2D MAPK3 EGR1 EGR2 JUND EGR3 EGR4 MAPK14 FOSL1 MAPK11 FRS2 REST CDK5 ID2 ID1 ID4 FOSB ID3 CDK5R2 CDK5R1 SHC1 PIK3R1 PIK3CA PLCG1 SOS1 RHOA STAT3 ATTENUATION PHASE%REACTOME DATABASE ID RELEASE 72%3371568 Attenuation phase HSBP1 HSF1 EP300 HSPA2 HSPA8 HSP90AB1 HSP90AA1 FKBP4 PTGES3 DNAJB1 CREBBP HSPA1L RAP1 SIGNALLING%REACTOME%R-HSA-392517.2 Rap1 signalling RAP1B YWHAZ RAF1 RAP1A SIPA1 RAPGEF3 RAP1GAP RAPGEF4 YWHAB RASGRP2 RASGRP1 PRKACG PRKACA PRKACB RAP1GAP2 EVASION OF ONCOGENE INDUCED SENESCENCE DUE TO DEFECTIVE P16INK4A BINDING TO CDK4%REACTOME DATABASE ID RELEASE 72%9630791 Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 CDK4 CDKN2A PERVASIVE DEVELOPMENTAL DISORDERS%REACTOME DATABASE ID RELEASE 72%9005895 Pervasive developmental disorders HDAC3 NCOR1 TBL1X CAMK4 HDAC1 TBL1XR1 GPS2 SIN3A PRKACA NCOR2 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER%REACTOME DATABASE ID RELEASE 72%5696397 Gap-filling DNA repair synthesis and ligation in GG-NER LIG1 POLK RPA1 POLE RPA2 POLD3 POLD4 RFC1 RPA3 POLD1 POLD2 RFC5 RFC3 RFC4 RFC2 UBA52 LIG3 XRCC1 POLE4 POLE2 UBB POLE3 UBC RPS27A PCNA ACTIVATED NTRK2 SIGNALS THROUGH FRS2 AND FRS3%REACTOME%R-HSA-9028731.1 Activated NTRK2 signals through FRS2 and FRS3 HRAS NTRK2 FRS2 PTPN11 SOS1 BDNF FRS3 NRAS NTF4 CONJUGATION OF CARBOXYLIC ACIDS%REACTOME DATABASE ID RELEASE 72%159424 Conjugation of carboxylic acids GLYAT ACSM1 ACSM2B GLYATL3 GLYATL2 GLYATL1 ACSM2A ACSM5 ACSM4 SIGNALING BY FGFR%REACTOME%R-HSA-190236.2 Signaling by FGFR BRAF POLR2E PTPN11 SPRY2 POLR2F POLR2H POLR2K POLR2L UBA52 FGF6 FGF9 ANOS1 PPP2R1A FGF20 FGF1 FGF2 ESRP1 FGF23 FGF3 MKNK1 FGF22 FGF10 FGF4 FGFRL1 FLRT2 FLRT1 HNRNPF KLB UBB UBC FGF19 FGFR4 RPS27A FGFBP1 FGFBP2 FGFBP3 NCBP1 MAPK1 NCBP2 MAPK3 GTF2F1 PPP2CA GTF2F2 PPP2CB POLR2A POLR2B POLR2C HNRNPM POLR2D POLR2G FRS2 FRS3 FGF16 FGF7 POLR2I POLR2J FGF18 PTBP1 GAB1 TIAL1 PIK3R1 CBL TIA1 RBFOX2 PIK3CA ESRP2 PLCG1 SOS1 SPRED2 SPRED1 HNRNPH1 HRAS FLRT3 NRAS GALNT3 HNRNPA1 NS1 MEDIATED EFFECTS ON HOST PATHWAYS%REACTOME%R-HSA-168276.5 NS1 Mediated Effects on Host Pathways NUP85 TPR NUP88 NUP43 EIF2AK2 ISG15 RAE1 RANBP2 NUP107 NUP155 NUP188 CPSF4 KPNA1 NUP153 NUP62 NUP35 PABPN1 NUPL2 NDC1 NUP214 SEC13 NUP37 NUP133 NUP210 NUP93 NUP50 NUP54 KPNA7 KPNA4 KPNA5 KPNA2 KPNA3 KPNB1 POM121 NUP205 AAAS NUP160 SIGNALLING TO ERKS%REACTOME%R-HSA-187687.1 Signalling to ERKs RAPGEF1 MAP2K1 MAPK14 MAP2K2 BRAF MAPK11 MAPKAPK3 FRS2 CRK SHC2 SHC1 SOS1 RALA HRAS RALGDS RALB MAPK12 CRKL RAP1A KIDINS220 MAPK13 RIT1 RIT2 NRAS YWHAB MAPKAPK2 NTRK1 SHC3 MAPK1 MAPK3 NGF RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER%REACTOME%R-HSA-76066.2 RNA Polymerase III Transcription Initiation From Type 2 Promoter POLR2E POLR2F POLR2H GTF3C1 GTF3C2 GTF3C3 GTF3C4 POLR2K GTF3C5 POLR2L GTF3C6 BRF1 BDP1 TBP CRCP POLR1C POLR3GL POLR3A POLR3B POLR3C POLR3D POLR3E POLR3F POLR3G POLR3H POLR3K INTEGRIN CELL SURFACE INTERACTIONS%REACTOME%R-HSA-216083.2 Integrin cell surface interactions ITGAM CDH1 ITGB2 ITGAL COL18A1 ITGAX COL16A1 COL13A1 VCAM1 ITGA2B COL23A1 COL4A2 COL4A1 LUM COL4A4 FGB FGA FN1 COL4A3 COL9A1 FGG ITGA5 ITGA9 COL9A3 COL9A2 HSPG2 SPP1 JAM2 JAM3 ITGB5 CD47 TNC COMP ITGA10 ITGA6 IBSP ITGA1 ITGB7 ITGA4 ICAM2 ICAM3 ICAM4 THBS1 ICAM5 ICAM1 CD44 F11R VTN ITGB3 ITGB1 ITGA11 FBN1 BSG ITGAE ITGB8 KDR ITGB6 ITGAV ITGA3 ITGAD ITGA2 ITGA8 AGRN ITGA7 INTEGRATION OF ENERGY METABOLISM%REACTOME DATABASE ID RELEASE 72%163685 Integration of energy metabolism PRKAR2B AKAP5 PRKAR2A CYSLTR2 GNAS CACNA2D2 GNA14 PPP2R1B ADCY4 GNA15 PPP2R1A ADCY3 PRKACG ADIPOR1 ADCY2 PRKACA ADIPOR2 ADCY1 PRKACB ADCY8 GNA11 ADCY7 PRKAA2 ADCY6 ADCY5 PPP2R5D PLCB3 SLC2A1 SLC2A2 PLCB1 PLCB2 FASN PFKFB1 GCG KCNC2 PRKAB2 PPP2CA KCNS3 PPP2CB ABCC8 IQGAP1 CHRM3 MLX CD36 CACNA1A CACNA1D CACNA1C CACNA1E CACNB2 CACNB3 SYT5 AHCYL1 RAPGEF3 AGPAT1 GNAQ RAPGEF4 PRKAG2 KCNB1 SNAP25 KCNG2 PRKCA STXBP1 STX1A VAMP2 ACACB ADRA2C ADIPOQ ACACA ITPR1 ADRA2A ITPR2 ITPR3 ACLY KCNJ11 MARCKS RAP1A STK11 ACSL4 GNG10 ACSL3 GNG12 GNG11 GNG13 GNB2 MLXIPL GNB1 GNB4 GNB3 GNB5 INS GNGT1 GNGT2 GNAI1 GNAI2 TKT GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 FFAR1 TALDO1 ADCY9 GLP1R PRKAR1B PRKAR1A ETHANOL OXIDATION%REACTOME%R-HSA-71384.2 Ethanol oxidation ADH1C ALDH2 ADH1B ADH1A ADH7 ADH5 ACSS2 ALDH1B1 ADH6 ADH4 ACSS1 ALDH1A1 PREGNENOLONE BIOSYNTHESIS%REACTOME%R-HSA-196108.2 Pregnenolone biosynthesis STARD4 TSPO STAR STARD6 FDXR CYP11A1 BZRAP1 FDX1 AKR1B1 FDX1L STARD3 STARD3NL REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE%REACTOME%R-HSA-176408.3 Regulation of APC C activators between G1 S and early anaphase PSMD3 CUL1 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 BUB1B CCNA2 CCNA1 UBA52 CDC20 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 ANAPC15 ANAPC16 PSMB6 ANAPC7 PSMB7 UBE2C PLK1 UBE2E1 PSMB4 UBE2D1 ANAPC10 PSMB5 ANAPC11 PSMB2 CCNB1 UBB CDC23 PSMB3 CDC26 CDC27 UBC CDC16 PSMB1 CDK1 ANAPC4 PSMF1 ANAPC5 ANAPC1 RPS27A ANAPC2 SHFM1 PSMB8 FBXO5 PSMB9 PSMC5 PSMC6 PSMC3 PSMC4 BUB3 PSMC1 PSMC2 FZR1 MAD2L1 CDK2 BTRC SKP1 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 CD209 (DC-SIGN) SIGNALING%REACTOME%R-HSA-5621575.1 CD209 (DC-SIGN) signaling PAK2 RPS6KA5 LYN HRAS EP300 RELB RAF1 NRAS NFKB1 CD209 PAK1 PRKACG PRKACA FYN PRKACB ICAM2 RELA PAK3 CREBBP ICAM3 PHOSPHATE BOND HYDROLYSIS BY NTPDASE PROTEINS%REACTOME DATABASE ID RELEASE 72%8850843 Phosphate bond hydrolysis by NTPDase proteins ENTPD1 ENTPD2 ENTPD3 ENTPD4 ENTPD5 ENTPD6 ENTPD7 ENTPD8 G BETA:GAMMA SIGNALLING THROUGH BTK%REACTOME%R-HSA-8964315.1 G beta:gamma signalling through BTK GNG11 GNG13 GNB2 GNB1 GNB4 GNB3 GNG3 GNG2 GNG5 GNB5 GNG4 GNG7 GNG8 GNGT1 GNGT2 BTK GNG10 GNG12 SODIUM-COUPLED SULPHATE, DI- AND TRI-CARBOXYLATE TRANSPORTERS%REACTOME%R-HSA-433137.1 Sodium-coupled sulphate, di- and tri-carboxylate transporters SLC13A1 SLC13A2 SLC13A3 SLC13A4 SLC13A5 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 72%2474795 Diseases associated with visual transduction OPN1LW ABCA4 OPN1MW OPN1MW2 TTR RDH12 NAPEPLD LRAT OPN1SW RDH5 RBP4 RBP1 STRA6 RLBP1 DEFECTIVE SLC2A2 CAUSES FANCONI-BICKEL SYNDROME (FBS)%REACTOME%R-HSA-5619098.2 Defective SLC2A2 causes Fanconi-Bickel syndrome (FBS) SLC2A2 TRANSMISSION ACROSS CHEMICAL SYNAPSES%REACTOME DATABASE ID RELEASE 72%112315 Transmission across Chemical Synapses GRIA2 CAMK2D PRKAR2B CAMK2A AKAP5 PRKAR2A GRIP1 CACNG8 EPB41L1 TSPAN7 MYO6 CACNG2 CAMK2G CACNG3 GRIA3 CACNG4 GRIA4 RASGRF2 PRKCG NSF DLG1 DLG4 PICK1 ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 PRKAA1 ADCY7 ADCY6 PRKAA2 ADCY5 GLS2 ARHGEF9 PLCB3 PLCB1 PLCB2 CHAT ACHE CACNA1A HRAS CACNA1E CACNB2 CACNB3 NRAS PRKX BCHE CAMK4 GNAT3 GLUL GNG10 GNG12 GNG11 GNG13 MAOA GNB2 GNB1 GNB4 GNB3 GNB5 GNGT1 GNGT2 GNAI3 GNAI1 GNAI2 GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 ABAT RPS6KA6 ARL6IP5 ACTN2 GABRG3 CACNA2D2 GABRG2 PRKACG PRKACA PRKACB GRIN2A GRIN2C GRIN2B GRIN2D GRIN3B GRIN3A GABRB3 GABRB2 GABRB1 ALDH2 GRIK5 GLS GRIK3 GRIK4 GRIK1 GRIK2 KIF17 SLC6A3 CACNA2D3 SLC6A4 GABRR3 PRKAB2 GABRR2 PRKAB1 GABRR1 NEFL CACNB1 GIT1 CACNB4 SLC18A3 SLC32A1 ALDH5A1 LRRC7 CHRNA1 CHRNB2 CHRND CAMKK1 CHRNB4 CAMKK2 CHRNA3 CHRNB3 GLRA1 CHRNA2 GLRA2 CHRNA5 GLRA3 CHRNG SLC17A7 CHRNA4 CHRNE GABRA2 GABRQ CHRNA6 SLC5A7 GABRA1 GABBR2 GABBR1 GABRA6 GABRA5 GABRA4 GAD1 GABRA3 GAD2 GRIN1 CAMK1 AP2A1 SLC38A1 PRKAG1 PRKAG2 NAAA SRC UNC13B PRKAG3 RAC1 CHRNA7 SLC1A1 SNAP25 RAB3A CHRNA9 PRKCB CACNA1B SYT1 CASK SLC1A2 PDPK1 SLC1A3 LIN7A SYN3 SLC1A6 LIN7C SLC1A7 CPLX1 LIN7B PRKCA SYN1 SLC38A2 SLC22A2 RIMS1 BZRAP1 KCNJ2 PPFIA1 SLC22A1 APBA1 KCNJ4 PPFIA4 STX1A KCNJ12 SLC18A2 VAMP2 PPFIA3 GNAL PPFIA2 DLG2 NBEA DLG3 RASGRF1 NRGN NPTN RPS6KA3 HTR3E HTR3C RPS6KA2 HTR3D RPS6KA1 HTR3A HTR3B LRTOMT DNAJC5 KPNA2 CREB1 SLC6A13 SLC6A12 SLC6A11 SLC6A1 HSPA8 PPM1E PPM1F NCALD MAPK1 MAPK3 KCNJ3 NRG1 KCNJ5 KCNJ6 KCNJ10 KCNJ9 KCNJ15 KCNJ16 GLRB COMT MDM2 ADCY9 PRKAR1B PRKAR1A GRIA1 CAMK2B DEFECTIVE SLC12A1 CAUSES BARTTER SYNDROME 1 (BS1)%REACTOME DATABASE ID RELEASE 72%5619104 Defective SLC12A1 causes Bartter syndrome 1 (BS1) SLC12A1 FCERI MEDIATED MAPK ACTIVATION%REACTOME DATABASE ID RELEASE 72%2871796 FCERI mediated MAPK activation IGKV3-11 LYN VAV1 VAV2 MAP2K4 PLCG2 IGKV2-28 MAPK9 MAPK8 PLCG1 PAK1 MAP2K7 SYK SOS1 MAP3K1 MAPK10 JUN IGKV3D-20 PAK2 IGKV1-12 HRAS FOS NRAS IGKV2D-28 IGKV4-1 IGKV2D-30 IGHE IGKV5-2 GRAP2 MAPK1 RAC1 LCP2 MAPK3 VAV3 DEFECTIVE SLC35A1 CAUSES CONGENITAL DISORDER OF GLYCOSYLATION 2F (CDG2F)%REACTOME DATABASE ID RELEASE 72%5619037 Defective SLC35A1 causes congenital disorder of glycosylation 2F (CDG2F) SLC35A1 BETA OXIDATION OF OCTANOYL-COA TO HEXANOYL-COA%REACTOME%R-HSA-77348.2 Beta oxidation of octanoyl-CoA to hexanoyl-CoA HADH HADHB HADHA ECHS1 ACADM EVASION OF OXIDATIVE STRESS INDUCED SENESCENCE DUE TO DEFECTIVE P16INK4A BINDING TO CDK4%REACTOME DATABASE ID RELEASE 72%9632697 Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 CDK4 CDKN2A POST-TRANSLATIONAL PROTEIN PHOSPHORYLATION%REACTOME%R-HSA-8957275.1 Post-translational protein phosphorylation SDC2 MEN1 LAMB2 APOE LAMB1 APOB MGAT4A TIMP1 CSF1 SPARCL1 APP HRC FGF23 DMP1 FSTL1 MSLN SPP2 GOLM1 TGOLN2 BMP15 APOA2 APOA1 ITIH2 QSOX1 APOA5 LGALS1 MATN3 MXRA8 SPP1 CALU MFI2 IL6 CHRDL1 CST3 CDH2 ENAM MFGE8 CP TF C4A RCN1 LTBP1 GPC3 BMP4 HSP90B1 EVA1A CHGB FBN1 C3 SERPINA10 PRSS23 AFP CKAP4 APOL1 ALB KTN1 ADAM10 NUCB1 IGFBP5 PNPLA2 GAS6 IGFBP4 SERPINC1 KNG1 AMBN TMEM132A FSTL3 CYR61 MEPE FGA FN1 SERPIND1 NOTUM FGG F5 VGF PROC IGFBP3 STC2 FUCA2 TNC IGFBP7 SERPINA1 FAM20C VWA1 FAM20A MBTPS1 PCSK9 AHSG BPIFB2 PENK MIA3 APLP2 SHISA5 SCG3 SCG2 AMELX WFS1 VCAN P4HB PDIA6 IGFBP1 AMTN DNAJC3 LAMC1 PRKCSH ANO8 AXIN MISSENSE MUTANTS DESTABILIZE THE DESTRUCTION COMPLEX%REACTOME DATABASE ID RELEASE 72%5467340 AXIN missense mutants destabilize the destruction complex CSNK1A1 PPP2CA PPP2CB PPP2R5B PPP2R5A PPP2R5D GSK3B PPP2R5C PPP2R1B PPP2R1A AMER1 AXIN1 APC PPP2R5E FRS-MEDIATED FGFR1 SIGNALING%REACTOME%R-HSA-5654693.3 FRS-mediated FGFR1 signaling HRAS FRS2 PTPN11 FRS3 NRAS FGF6 FGF9 SOS1 FGF20 FGF1 FGF2 FGF23 FGF3 FGF22 FGF10 FGF4 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS%REACTOME%R-HSA-205043.1 NRIF signals cell death from the nucleus NCSTN APH1B NGFR UBB UBC RPS27A UBA52 MAPK8 PSENEN TRAF6 PSEN2 SQSTM1 PSEN1 ITGB3BP NGF APH1A ACTIVATION OF NIMA KINASES NEK9, NEK6, NEK7%REACTOME DATABASE ID RELEASE 72%2980767 Activation of NIMA Kinases NEK9, NEK6, NEK7 NEK7 CDK1 PLK1 CCNB1 CCNB2 NEK9 NEK6 HDR THROUGH HOMOLOGOUS RECOMBINATION (HRR)%REACTOME DATABASE ID RELEASE 72%5685942 HDR through Homologous Recombination (HRR) EXO1 POLK RPA1 POLE RPA2 POLH POLD3 TOPBP1 RFC1 RTEL1 POLD4 WRN RPA3 POLD1 RMI2 POLD2 RFC5 DNA2 SPIDR RFC3 RMI1 RFC4 TOP3A RFC2 RAD51D UBA52 XRCC2 XRCC3 MRE11A POLE4 RAD51 RBBP8 BRCA2 POLE2 UBB RAD1 POLE3 UBC RPS27A RAD51B KAT5 RAD50 CHEK1 RAD51C NBN SLX4 HUS1 RHNO1 EME1 EME2 GEN1 BRIP1 SLX1B ATRIP BARD1 SLX1A RAD51AP1 RAD17 ATM PALB2 ATR RAD9B RAD9A BRCA1 MUS81 BLM PCNA HDR THROUGH MMEJ (ALT-NHEJ)%REACTOME%R-HSA-5685939.1 HDR through MMEJ (alt-NHEJ) PARP1 XRCC1 PARP2 RAD50 RBBP8 LIG3 POLQ NBN FEN1 MRE11A VEGFR2 MEDIATED CELL PROLIFERATION%REACTOME%R-HSA-5218921.3 VEGFR2 mediated cell proliferation PDPK1 SPHK1 HRAS PRKCD PRKCA RASA1 PRKCZ AHCYL1 NRAS ITPR1 ITPR2 ITPR3 PLCG1 KDR PRKCB SIGNALING BY HIPPO%REACTOME%R-HSA-2028269.1 Signaling by Hippo DVL2 NPHP4 WWC1 YAP1 TJP1 STK4 STK3 SAV1 LATS1 MOB1B TJP2 MOB1A LATS2 YWHAB CASP3 AMOTL2 AMOTL1 YWHAE WWTR1 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA%REACTOME%R-HSA-212718.2 EGFR interacts with phospholipase C-gamma EGFR PLCG1 BTC EPGN TGFA AREG HBEGF EREG EGF DEFECTIVE GALNT12 CAUSES COLORECTAL CANCER 1 (CRCS1)%REACTOME%R-HSA-5083636.1 Defective GALNT12 causes colorectal cancer 1 (CRCS1) MUC1 MUC7 MUC12 MUC20 MUC4 MUC13 MUC6 MUC15 MUC17 MUC5B MUC21 MUCL1 MUC3A MUC5AC GALNT12 METAL SEQUESTRATION BY ANTIMICROBIAL PROTEINS%REACTOME%R-HSA-6799990.1 Metal sequestration by antimicrobial proteins S100A7A S100A9 S100A8 LCN2 S100A7 LTF ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 72%68867 Assembly of the pre-replicative complex PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 UBA52 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 E2F1 PSMB4 PSMB5 PSMB2 UBB PSMB3 UBC PSMB1 PSMF1 RPS27A SHFM1 GMNN PSMB8 PSMB9 PSMC5 PSMC6 PSMC3 ORC5 PSMC4 ORC4 PSMC1 ORC6 PSMC2 ORC1 ORC3 ORC2 E2F2 CDT1 E2F3 CDC6 MCM7 MCM8 MCM3 MCM4 MCM5 MCM6 MCM2 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 INHIBITION OF PKR%REACTOME DATABASE ID RELEASE 72%169131 Inhibition of PKR EIF2AK2 OTHER INTERLEUKIN SIGNALING%REACTOME%R-HSA-449836.10 Other interleukin signaling CD4 PTPRZ1 STXBP2 IFNL1 IFNLR1 STX1A VAMP2 IL16 TYK2 STX3 IL10RB CSF3 CSF3R CASP3 JAK1 CSF1 IL32 IL34 STX4 PRTN3 TXLNA SDC1 CSF1R SNAP25 RAS GTPASE CYCLE MUTANTS%REACTOME%R-HSA-9649913.1 RAS GTPase cycle mutants HRAS NRAS KRAS INSULIN PROCESSING%REACTOME DATABASE ID RELEASE 72%264876 Insulin processing TMEM27 MYO5A STX1A INS RAB27A VAMP2 CPE PCSK2 PCSK1 ERO1LB ERO1L KIF5C KIF5B KIF5A EXOC8 EXOC7 MYRIP SLC30A7 SLC30A6 SLC30A8 EXOC4 EXOC3 EXOC6 SLC30A5 EXOC5 EXOC2 EXOC1 TRANSPORT OF NUCLEOSIDES AND FREE PURINE AND PYRIMIDINE BASES ACROSS THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 72%83936 Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane SLC25A4 SLC25A6 SLC29A4 SLC28A2 SLC29A1 SLC28A1 ARL2 SLC29A3 SLC28A3 SLC29A2 ARL2BP SLC25A5 MITOTIC METAPHASE AND ANAPHASE%REACTOME%R-HSA-2555396.2 Mitotic Metaphase and Anaphase PPP2R5C ERCC6L ZWILCH BUB1B CASC5 SMC3 CDC20 PTTG1 KNTC1 DYNC1LI1 BIRC5 DYNC1LI2 CLIP1 ZW10 MAD1L1 CDCA5 CDCA8 PDS5B PDS5A PMF1 SKA1 AURKB SKA2 DSN1 RAD21 RCC2 NDC80 ZWINT STAG1 KIF18A STAG2 SGOL2 SGOL1 NUF2 WAPAL SPDL1 NDEL1 NUDC SMC1A DYNLL2 ESPL1 KIF2A INCENP KIF2C KIF2B ITGB3BP MIS12 CENPA NSL1 CENPC BUB3 BUB1 DYNC1I1 CLASP2 CENPT LMNB1 CENPU CENPE CENPF CENPH CENPI TAOK1 CENPK CENPL CHMP2A CENPM CENPN B9D2 CENPO CENPP CENPQ SPC24 MAD2L1 SPC25 UBE2I DYNLL1 CKAP5 MAPRE1 PAFAH1B1 DYNC1I2 CCNB2 CLASP1 DYNC1H1 NDE1 TUBB6 ANAPC15 ANAPC16 TUBB3 ANAPC7 TUBB1 UBE2C PLK1 UBE2E1 UBE2D1 ANAPC10 ANAPC11 CCNB1 CDC23 CDC26 CDC27 CDC16 CDK1 ANAPC4 TUBA4B ANAPC5 ANAPC1 TUBA4A ANAPC2 KPNB1 FBXO5 APITD1 TUBA8 TUBA1C TUBA1B TUBA1A TUBB2B TUBB2A TUBAL3 TUBA3E IST1 TUBB4B TUBB4A PPP1CC NUP107 NUP188 BANF1 PPP2R1B PPP2R1A NUP62 NDC1 SEC13 NUP133 PPP2R5D NUP93 LBR NUP54 ANKLE2 EMD VRK1 LEMD3 SIRT2 POM121 NUP205 NUP160 PPP2CA PPP2CB NUP85 NUP43 RANBP2 NUP155 NUP35 NUP37 PSMD8 PSMD9 PSMD6 XPO1 PSMD7 PSMD4 PSMD5 PSMD2 SUMO1 PPP2R5E PSMD3 PSMD1 TNPO1 PPP2R5B PPP2R5A VPS4A PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 CHMP2B PSME2 CHMP4C UBA52 CHMP4B CHMP3 CHMP4A PSMD10 CHMP6 PSMB11 PSMD12 PPP2R2A PSMD11 CHMP7 RPS27 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 UBB PSMB3 UBC PSMB1 PSMF1 RPS27A SHFM1 PSMB8 PSMB9 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 AHCTF1 RANGAP1 RCC1 RAN TUBB8P12 TUBB8 SPAST LEMD2 CC2D1B PLATELET CALCIUM HOMEOSTASIS%REACTOME%R-HSA-418360.1 Platelet calcium homeostasis TRPC7 SRI TRPC6 TRPC3 STIM1 P2RX7 P2RX6 P2RX5 ORAI2 P2RX4 ORAI1 P2RX3 P2RX2 P2RX1 ATP2B4 ITPR1 ATP2B3 ITPR2 ATP2B2 ITPR3 ATP2B1 SLC8A3 ATP2A3 SLC8A1 ATP2A2 SLC8A2 ATP2A1 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC)%REACTOME DATABASE ID RELEASE 72%975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) RPL26 RPL29 RPL10L RPS4X RPL10A RPL28 RPS3A RPL7A RPL23A FAU RPL41 RPS27L PABPC1 RPL3L UBA52 RPL37A RPS26 RPS25 RPS28 GSPT2 GSPT1 RPS27 RPL36A RPS29 RPL35A RPS20 RPS21 RPS24 RPS23 UPF1 ETF1 RPL22L1 RPS4Y2 RPL10 RPS4Y1 RPS27A RPL12 RPL13A RPL11 RPS3 RPL14 RPL13 NCBP1 NCBP2 RPS2 RPL15 RPL18 RPL17 RPL19 EIF4G1 RPL27A RPL26L1 RPL4 RPL39L RPL5 RPL30 RPL3 RPL32 RPL31 RPS9 RPS7 RPL34 RPS8 RPL8 RPS5 RPL9 RPS6 RPL6 RPL7 RPSA RPL36 RPS15 RPS14 RPL35 RPS17 RPL38 RPS16 RPL37 RPL39 RPS19 RPS15A RPL18A RPL36AL RPS18 RPLP1 RPL21 RPL23 RPS11 RPL22 RPLP0 RPS10 RPS13 RPS12 RPLP2 RPL24 RPL27 REVERSIBLE HYDRATION OF CARBON DIOXIDE%REACTOME%R-HSA-1475029.1 Reversible hydration of carbon dioxide CA14 CA5B CA13 CA5A CA12 CA1 CA3 CA2 CA4 CA7 CA6 CA9 INTERLEUKIN-15 SIGNALING%REACTOME DATABASE ID RELEASE 72%8983432 Interleukin-15 signaling IL2RB IL15RA GRB2 SOS2 STAT5A STAT5B IL15 SHC1 GAB2 IL2RG JAK1 JAK3 STAT3 SOS1 PROLONGED ERK ACTIVATION EVENTS%REACTOME%R-HSA-169893.1 Prolonged ERK activation events RAPGEF1 MAP2K1 MAP2K2 BRAF FRS2 KIDINS220 CRKL RAP1A CRK YWHAB NTRK1 MAPK1 NGF MAPK3 BIOSYNTHESIS OF A2E, IMPLICATED IN RETINAL DEGRADATION%REACTOME%R-HSA-2466712.1 Biosynthesis of A2E, implicated in retinal degradation NAPEPLD BASE EXCISION REPAIR%REACTOME%R-HSA-73884.2 Base Excision Repair LIG1 RPA1 POLE RPA2 POLD3 TDG RFC1 POLD4 RPA3 POLD1 POLD2 RFC5 TINF2 RFC3 NEIL3 TERF2IP RFC4 NEIL2 NEIL1 RFC2 PARG PNKP HIST1H2AE NTHL1 HIST1H2AD HIST3H2BB HIST1H2AC ACD HIST1H2AB HIST1H2AJ XRCC1 HIST1H2BF HIST1H2BE SMUG1 HIST1H2BH HIST1H2BG POLE4 HIST1H2BB HIST1H2BA HIST1H2BD OGG1 HIST1H2BC H2AFB1 POLE2 HIST3H3 POLE3 PARP1 PARP2 TERF1 TERF2 POT1 HIST1H4K HIST1H4L H2BFS HIST1H4A MBD4 HIST1H4B HIST1H4H HIST1H4I HIST1H4J HIST1H4C APEX1 HIST1H4D HIST1H4E MPG HIST1H4F HIST2H2AA3 HIST2H2AA4 HIST2H2AC ADPRHL2 H2AFJ LIG3 H2AFZ H2AFX H2AFV HIST2H2BE HIST4H4 HIST1H2BN HIST1H2BM HIST1H2BO HIST1H2BJ HIST1H2BI HIST1H2BL HIST1H2BK HIST2H4A FEN1 POLB HIST2H4B PCNA DEFECTIVE SLC5A1 CAUSES CONGENITAL GLUCOSE GALACTOSE MALABSORPTION (GGM)%REACTOME%R-HSA-5656364.2 Defective SLC5A1 causes congenital glucose galactose malabsorption (GGM) SLC5A1 ION TRANSPORT BY P-TYPE ATPASES%REACTOME%R-HSA-936837.2 Ion transport by P-type ATPases ATP1A2 CAMK2D ATP1A1 CAMK2A SRI ATP10D PLN ATP10B ATP10A ATP2C2 ATP2C1 CAMK2G ATP9B ATP9A ATP2B4 ATP2B3 ATP2B2 ATP2B1 ATP13A1 ATP13A4 ATP13A5 ATP13A2 SLN PDZD11 ATP8A2 ATP8A1 ATP12A ATP1B3 ATP1B2 ATP11C ATP11B ATP1B1 ATP11A FXYD4 FXYD3 FXYD2 FXYD1 FXYD7 FXYD6 ATP8B4 ATP8B3 ATP8B2 ATP8B1 ATP4B ATP4A ATP2A3 ATP2A2 ATP2A1 CUTC ATP7B ATP7A ATP1A4 CAMK2B ATP1A3 COLLAGEN DEGRADATION%REACTOME%R-HSA-1442490.3 Collagen degradation MMP3 ADAM10 COL17A1 COL18A1 COL15A1 COL16A1 COL13A1 COL14A1 COL12A1 COL19A1 COL26A1 COL25A1 COL23A1 ADAM9 PHYKPL COL9A1 MMP20 ADAM17 CTSD MMP10 COL9A3 CTSL MMP12 CTSK MMP11 COL9A2 CTSB MMP14 MMP13 PRSS2 ELANE MMP15 MMP19 MMP8 MMP7 MMP9 TMPRSS6 FURIN MMP1 MMP2 RUNX3 REGULATES WNT SIGNALING%REACTOME%R-HSA-8951430.1 RUNX3 regulates WNT signaling LEF1 RUNX3 TCF7 TCF7L2 TCF7L1 MYC CTNNB1 CCND1 MITOTIC SPINDLE CHECKPOINT%REACTOME%R-HSA-69618.2 Mitotic Spindle Checkpoint PPP1CC NUP107 PPP2R5C ERCC6L ZWILCH BUB1B CASC5 CDC20 PPP2R1B PPP2R1A KNTC1 DYNC1LI1 BIRC5 DYNC1LI2 CLIP1 ZW10 MAD1L1 CDCA8 SEC13 PMF1 NUP133 SKA1 AURKB SKA2 DSN1 PPP2R5D RCC2 NDC80 ZWINT KIF18A SGOL2 SGOL1 NUF2 SPDL1 NDEL1 NUDC DYNLL2 KIF2A INCENP KIF2C KIF2B ITGB3BP MIS12 CENPA NSL1 NUP160 CENPC PPP2CA BUB3 PPP2CB BUB1 NUP85 DYNC1I1 CLASP2 CENPT CENPU NUP43 CENPE CENPF CENPH CENPI TAOK1 RANBP2 CENPK CENPL CENPM CENPN B9D2 CENPO CENPP CENPQ SPC24 MAD2L1 SPC25 NUP37 DYNLL1 CKAP5 MAPRE1 PAFAH1B1 XPO1 DYNC1I2 PPP2R5E PPP2R5B PPP2R5A CLASP1 DYNC1H1 NDE1 RPS27 ANAPC15 ANAPC16 ANAPC7 UBE2C PLK1 UBE2E1 UBE2D1 ANAPC10 ANAPC11 CDC23 CDC26 CDC27 CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 APITD1 AHCTF1 RANGAP1 UPTAKE AND FUNCTION OF DIPHTHERIA TOXIN%REACTOME%R-HSA-5336415.1 Uptake and function of diphtheria toxin TXNRD1 HSP90AB1 CD9 HSP90AA1 HBEGF EEF2 DEFECTIVE SLC27A4 CAUSES ICHTHYOSIS PREMATURITY SYNDROME (IPS)%REACTOME%R-HSA-5619108.1 Defective SLC27A4 causes ichthyosis prematurity syndrome (IPS) SLC27A4 TICAM1 DEFICIENCY - HSE%REACTOME DATABASE ID RELEASE 72%5602566 TICAM1 deficiency - HSE TICAM1 TLR3 NEF MEDIATED CD4 DOWN-REGULATION%REACTOME DATABASE ID RELEASE 72%167590 Nef Mediated CD4 Down-regulation ARF1 CD4 AP2A1 AP2B1 AP2A2 AP2S1 AP2M1 ATP6V1H LCK SIGNALING BY FGFR2%REACTOME%R-HSA-5654738.2 Signaling by FGFR2 BRAF POLR2E PTPN11 SPRY2 POLR2F POLR2H POLR2K POLR2L UBA52 FGF6 FGF9 PPP2R1A FGF20 FGF1 FGF2 ESRP1 FGF23 FGF3 MKNK1 FGF22 FGF10 FGF4 HNRNPF UBB UBC RPS27A FGFBP1 FGFBP2 FGFBP3 NCBP1 MAPK1 NCBP2 MAPK3 GTF2F1 PPP2CA GTF2F2 PPP2CB POLR2A POLR2B POLR2C HNRNPM POLR2D POLR2G FRS2 FRS3 FGF16 FGF7 POLR2I POLR2J FGF18 PTBP1 GAB1 TIAL1 PIK3R1 CBL TIA1 RBFOX2 PIK3CA ESRP2 PLCG1 SOS1 HNRNPH1 HRAS NRAS HNRNPA1 NTRK2 ACTIVATES RAC1%REACTOME%R-HSA-9032759.1 NTRK2 activates RAC1 DOCK3 NTRK2 BDNF RAC1 ALPHA-DEFENSINS%REACTOME DATABASE ID RELEASE 72%1462054 Alpha-defensins CD4 DEFA1B DEFA6 PRSS2 DEFA5 DEFA3 PRSS3 DEFA4 ART1 DEFA1 DOWNSTREAM SIGNALING OF ACTIVATED FGFR3%REACTOME%R-HSA-5654708.1 Downstream signaling of activated FGFR3 HRAS FRS2 PTPN11 FRS3 FGF16 FGF18 NRAS GAB1 PIK3R1 PIK3CA FGF9 PLCG1 SOS1 FGF20 FGF1 FGF2 FGF23 FGF4 SULFUR AMINO ACID METABOLISM%REACTOME DATABASE ID RELEASE 72%1614635 Sulfur amino acid metabolism APIP GADL1 TXN2 MAT1A SQRDL CBS ADI1 GOT1 ENOPH1 TSTD1 GOT2 SUOX CTH CSAD ADO MTRR CDO1 MPST MTAP BHMT2 BHMT AHCY MRI1 MTR SLC25A10 TST ETHE1 PLASMA LIPOPROTEIN CLEARANCE%REACTOME DATABASE ID RELEASE 72%8964043 Plasma lipoprotein clearance APOE APOB AMN HDLBP PCSK9 VLDLR LIPA LIPC LDLRAP1 MYLIP LSR SOAT1 NPC1 SOAT2 NPC2 APOC4 APOBR CUBN NCEH1 CLTC APOC1 CLTA LDLR AP2A1 AP2B1 AP2A2 AP2S1 NR1H2 APOA1 AP2M1 NR1H3 CES3 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS%REACTOME DATABASE ID RELEASE 72%446219 Synthesis of substrates in N-glycan biosythesis NEU2 NEU3 NEU1 DPM1 DPM2 DPM3 SLC35A1 SLC35C1 CTSA ST3GAL4 SRD5A3 ST3GAL6 ST3GAL1 MVD ST3GAL2 ST3GAL3 GLB1 ST6GALNAC1 GMPPB ST6GALNAC2 FPGT CMAS GMPPA PGM3 NPL NANP GNPNAT1 ST6GALNAC6 NUDT14 NEU4 ALG5 ST8SIA4 SLC17A5 RENBP ST8SIA5 MPI ST3GAL5 TSTA3 ST8SIA6 NANS UAP1 ST6GAL1 FUOM ST6GAL2 GMDS AMDHD2 ST8SIA1 FUK ST8SIA2 PMM1 ST8SIA3 ST6GALNAC3 GFPT2 ST6GALNAC4 NAGK DHDDS ST6GALNAC5 DOLPP1 GNE GFPT1 NUS1 PMM2 DOLK INHIBITION OF HOST MRNA PROCESSING AND RNA SILENCING%REACTOME%R-HSA-168315.4 Inhibition of Host mRNA Processing and RNA Silencing CPSF4 PABPN1 HYALURONAN UPTAKE AND DEGRADATION%REACTOME%R-HSA-2160916.3 Hyaluronan uptake and degradation HEXB HYAL1 HYAL2 HEXA STAB2 CD44 HYAL3 HMMR CHP1 GUSB SLC9A1 LYVE1 MOLYBDENUM COFACTOR BIOSYNTHESIS%REACTOME%R-HSA-947581.1 Molybdenum cofactor biosynthesis GPHN MOCS2 MOCS3 MOCOS OXIDATIVE STRESS INDUCED SENESCENCE%REACTOME%R-HSA-2559580.4 Oxidative Stress Induced Senescence CBX6 RBBP4 RBBP7 SUZ12 TFDP1 MAPK8 TFDP2 E2F1 BMI1 RNF2 CBX8 PHC2 PHC1 RING1 CBX4 CBX2 TNRC6C PHC3 TNRC6A TNRC6B E2F2 MAP2K3 E2F3 MAP2K4 TP53 TXN MAPK9 CDK4 MAP2K7 MAPK10 JUN MOV10 AGO3 KDM6B AGO4 AGO1 MAPKAPK3 CDK6 UBA52 HIST1H2AE HIST1H2AD HIST3H2BB HIST1H2AC HIST1H2AB HIST1H2AJ CDKN2A HIST2H3A HIST1H2BF HIST1H2BE HIST1H2BH HIST1H2BG HIST2H3D HIST1H2BB HIST1H2BA HIST2H3C HIST1H2BD HIST1H2BC H2AFB1 FOS UBB HIST1H3J HIST1H3A UBC HIST1H3F HIST1H3G HIST1H3H HIST1H3I MAPKAPK2 RPS27A HIST1H3B HIST1H3C HIST1H3D HIST1H3E H3F3B HIST1H4K CDKN2D HIST1H4L MAPK1 CDKN2B H3F3A CDKN2C MAPK3 H2BFS HIST1H4A MAP3K5 HIST1H4B HIST1H4H TNIK HIST1H4I MAPK14 HIST1H4J HIST1H4C MAPK11 HIST1H4D HIST1H4E MAPKAPK5 EZH2 HIST1H4F HIST2H2AA3 HIST2H2AA4 HIST2H2AC MAP2K6 H2AFJ EED H2AFZ H2AFX H2AFV HIST2H2BE HIST4H4 MDM2 MDM4 MINK1 HIST1H2BN HIST1H2BM HIST1H2BO HIST1H2BJ MAP4K4 IFNB1 HIST1H2BI HIST1H2BL HIST1H2BK HIST2H4A HIST2H4B SIGNALING PATHWAYS%REACTOME DATABASE ID RELEASE 72%162582 Signaling Pathways GRM7 INTU GRM6 CUL1 PRKAR2B GPER1 GRM8 KIF3A CDH1 QRFPR IQGAP2 PRKAR2A TTC21B IQGAP3 SSTR1 SSTR2 MEN1 PTCH1 SSTR4 IFT122 FUZ SSTR5 CNR2 ADCY10 GNAS CNR1 MKS1 TAS1R2 TAS1R1 GLI1 TAS1R3 GLI3 CCK GLI2 IFT52 OPN1SW ALDH1A1 SUFU ACKR1 IFT57 RXFP4 GRPR OFD1 IFT140 RXFP3 KIF7 PROK2 PROK1 WDR35 CMKLR1 GNA14 NUMB ADCY4 GNA15 TRHR ADCY3 GALR3 TULP3 GALR2 ADCY2 GALR1 ADCY1 WNT10B ADCY8 GNA11 WNT10A ADCY7 FZD9 ADCY6 GPR183 ADCY5 PNOC CSNK1A1 GPR132 WDR19 OPN1LW ITCH DDX5 GAST OPN1MW RGR GPR4 CTBP1 HCAR2 GPR143 HCAR3 DGKG BMI1 HCAR1 DGKE RNF2 CHRM1 DGKD DGKB NRIP1 CBX8 CHRM4 LRAT DGKA PHC2 CHRM5 PHC1 GUCA1B RING1 GUCA1A CBX4 GUCA1C CBX2 ABHD12 HSPG2 DGKZ MTNR1A MKL1 MTNR1B DGKQ PHC3 DGKK PPEF1 RBP4 FOXO1 DGKI RBP2 DGKH ABHD6 RBP1 NCBP1 STRA6 NCBP2 DAGLA TRH CD86 LCK INSL5 CD80 GTF2F1 DAGLB CD28 GTF2F2 RCVRN POLR2A METAP1 POLR2B METAP2 POLR2C OXTR POLR2D FOXO3 RRH POLR2G UHMK1 EDNRA BCL2 NELFB EDNRB UTS2R GPR37L1 RETSAT POLR2I UTS2B POLR2J PTGFR NLN PPY IQGAP1 NTSR1 MTMR4 NTSR2 NMB NMBR NMS NMU QRFP BRS3 CCKAR FFAR3 FFAR2 EDN1 EDN2 EDN3 AVPR1B AVPR1A CCKBR SPRED3 NPB GUCY2D SPRED2 PTGER1 SPRED1 SYNGAP1 PTGER3 GPIHBP1 HRAS GUCY2F ABCA1 RASA3 NPW KISS1R RASA4 F2RL1 RASA1 F2RL2 RASA2 F2RL3 CUL3 CCL4L2 RASAL1 PMCH RASAL2 RASAL3 NPY2R NRAS SDR9C7 DAB2IP GHSR NF1 NPY1R KBTBD7 RGS9BP APLNR SUCNR1 NTS OPN4 OPN3 C3 PTCH2 OPN5 PYY NMUR2 NMUR1 GPSM1 TAS2R7 GPSM2 FURIN PCSK6 TAS2R9 NGF TAS2R8 WNT2B PCSK5 MLNR HEBP1 PDE4B BDKRB2 BDKRB1 TAS2R1 TAS2R3 GPSM3 TAS2R5 TAS2R4 NPY5R WNT16 CORT DLD RGS18 RGS14 RGS13 NPY4R OPRL1 GNA12 RGS21 S1PR3 RGS22 S1PR2 S1PR5 S1PR4 OPRK1 KISS1 RGS10 RGS12 AR FABP5 FABP6 FABP7 THEM4 MYC CDKN2B EPO FKBP5 HSP90AB1 PIK3CD PIK3CG EGF SHC1 GAB1 PIK3R1 CBL EGFR PIK3CA PPP1R15A PLCG1 SOS1 E2F5 PIK3C3 ZDHHC7 CRABP2 LRP1 TGFB1 RXRG SMAD4 SMURF1 IGF1R ARHGEF18 RUNX3 PPID CGN F11R CAV2 PRKCZ TGFBR1 RHOA TGFBR2 FKBP1A LRP2 PARD6A PARD3 LRP8 VEGFA CBX6 CXCL8 CCNC FGF6 FGF9 ANOS1 FGF20 FGF1 FGF2 FGF23 FGF3 FGF22 FGF10 FGF4 UCN PIK3R4 PIK3R3 KIF5B KIF5A FFAR4 PIK3R6 PIK3R5 CTSD GRP TCF7L2 CMA1 WASL INHBB INHBA IGF1 NCOA1 NCOA2 NCOA3 RXRB RXRA PRR5 CYFIP2 GPC1 CYFIP1 NCKAP1 GPC3 AHCYL1 GPC2 NCF1 GPC5 NCF2 GPC4 ITGB3 GPC6 NCF4 CTNND1 BRK1 PIK3CB SHB AKR1C1 CDH5 AKT2 AKR1C3 AKT3 MLST8 KDR GRAP2 NCK2 ITGAV AKR1C4 RAC1 NCK1 PPP1CA PTAFR VAV3 PRKCB PDPK1 NCAM1 SPHK1 CYBB CYBA VAV1 VAV2 MAPKAPK3 ELMO1 ELMO2 TRIB3 CRK DOCK1 SHC2 ROCK1 ROCK2 CCND3 MAPKAP1 SH2D2A PXN ITPR1 ITPR2 ITPR3 PIK3R2 CDC42 PAK1 CTNNA1 PTK2B RICTOR NCKAP1L FYN WASF1 PAK3 WASF2 PAK2 WASF3 JUP NOS3 CAV1 BAIAP2 MTOR PTK2 MAPK12 MAPK13 ABI2 AXL ABI1 CTNNB1 BCAR1 CYP26A1 CYP26B1 CYP26C1 INS CASP8 TRADD TNFSF10 FAS TNFRSF10B FASLG RIPK1 TNFRSF10A TRAF2 FADD TRIO PRDM4 SPPL2B ITSN1 SPPL2A TNF PREX1 ARHGEF40 PRKCI USP4 MED1 OMG CLIP3 MAG OBSCN NGFRAP1 RBCK1 NGEF NSMAF VCP ARHGEF26 MAGED1 PSEN2 SEL1L PSEN1 CLPS KALRN DERL2 RTN4 APH1A ABR BAG4 OS9 NCSTN BCL2L11 APH1B SHARPIN ECT2 ARHGEF33 ARHGEF35 ARHGEF37 ARHGEF39 PLCG2 SYVN1 ARHGEF38 GNB2L1 NET1 CYLD RASGRF2 OTUD7B TNFAIP3 ARHGEF10L AATF AKAP13 CASP3 MCF2L PSENEN NTRK2 ARHGEF11 NTF3 ARHGEF10 ARHGEF12 PLEKHG2 ARHGEF15 ARHGEF17 PLEKHG5 ARHGEF16 ARHGEF19 TRAF1 TNFRSF1A ARHGEF9 ARHGEF3 TAX1BP1 ARHGEF4 ARHGEF1 ARHGEF2 SOS2 ARHGEF5 BIRC2 BIRC3 PLCB3 PLCB4 RNF31 XIAP FGD1 FGD2 PLCB1 FGD3 PLCB2 GNA13 FGD4 LINGO1 USP21 MCF2 CFLAR OTULIN GPS2 NTRK1 PORCN AGT CHRM3 SMAD7 UCHL5 USP15 RPS6 PSAP CDK8 WIPF1 WIPF2 WIPF3 C3AR1 NOX1 ARPC1B ARPC1A ADRA2C WAS NOXO1 ADRA2A MYO9B ACTG1 NCKIPSD DVL1 FST DVL3 ARPC4 FOXH1 ARPC5 ACVR1B ARPC2 ACVR2B ARPC3 ACVR2A NOXA1 FSTL3 DRAP1 ACTR3 ACVR1C ACTR2 FPR1 FPR2 NOTCH1 MAML2 MAML1 RBPJ HES1 INPP5B SNW1 MAML3 MAMLD1 AKR1B10 FFAR1 DLAT S100A9 S100A8 PBX1 RARG RARA RARB TBL1X OCRL TBL1XR1 TERT B4GALT1 PREX2 MATK PPBP USP13 TNKS CCNK TNKS2 NLK PRKG1 WWP2 RNF146 STUB1 FRK OTUD3 KAT5 CYP4V2 CHEK1 PIP4K2A PIP4K2B PIP4K2C TSHB SLC24A1 PRKAB2 PDE6G CNGA1 PRKAB1 RHO RRAGA SAG PDE6B PDE6A CNGB1 RRAGC RRAGB RRAGD TP53 CXCR1 CXCR2 SFN POMC JUN SCD CREBBP MOV10 AGO3 AGO4 AGO1 AGO2 CDKN1A CDKN1B CXCL1 ADGRE5 PRKAG1 ADGRE3 PRKAG2 MMP9 PRKAG3 RPTOR CASP10 PRMT1 ITGA2B ARAF PEBP1 ARRB2 KSR1 KSR2 APBB1IP CNKSR2 CNKSR1 ESRP1 VCL RAP1B MARK3 FN1 YAP1 LAMTOR2 CSF2 LAMTOR1 LAMTOR4 LAMTOR3 LAMTOR5 CCNT2 KPNA2 IL2 CCNT1 JAK1 CDC14A IL2RA CDC14B SEPT7 STK11 RAG2 RAG1 ETV4 CDC42EP5 CDC42EP3 CDC42EP2 USP7 DNAJB1 IGF2BP1 USP2 MAPK6 MAPK4 FLNA TSC2 TSC1 CDC25C EIF4E STAT1 FRS2 FRS3 NRP1 CCNE1 FGF16 NEDD4 FGF7 MAPKAPK5 FGF18 PDGFRA SLC38A9 CAB39 CAB39L EEF2K EIF4EBP1 EIF4B STRADA TNFRSF10D STRADB PPM1A CDK9 RPS6KB1 AKT1S1 RHEB CDK2 MDM2 PIN1 YWHAE PTEN YWHAQ CXCL6 CXCL9 CASP2 CXCL3 CXCL13 CXCL2 CX3CL1 YWHAG CXCL5 CXCL16 CCRL2 YWHAH CCR9 CCR8 CCR7 CCR6 CCR4 CCR3 PPP2R5C CCR2 XCL2 XCL1 CX3CR1 CCL13 CCL11 TFDP1 CCL3L1 RBL1 CCL3L3 TFDP2 CXCR5 CXCR6 BIRC5 CCL7 APP CCL5 CXCR3 PRKAA1 CCL4 CCL3 PRKAA2 ARRB1 CCL2 CCL1 CCL19 CCL17 CCL16 CCR10 AURKB SH3GL2 CCL25 CCR1 E2F1 SSTR3 CCL22 XCR1 E2F4 CCL21 CCL20 CXCL10 CXCL11 ACKR4 ACKR3 ACKR2 MCHR1 CCL28 CCL27 MYH14 MYH10 PML TNRC6C CARM1 ABCG8 ABCG5 BAX ARL4C EEPD1 TNRC6A TNRC6B E2F3 RNF43 WNT3A FZD4 FZD6 LRP5 FZD8 LRP6 BTC EPGN TGFA AREG HBEGF EREG RNF41 KNG1 A2M FGB GNAT2 FGA GNAT3 VWF GNAT1 F2R RGS9 FGG RGS6 F2 RGS7 GNAZ PF4 GNG10 EVL TRAT1 GNG12 GNG11 GNG13 GNAO1 GNB2 GNB1 GNB4 GNB3 GNB5 GNGT1 GNGT2 HDAC3 GNAI3 GNAI1 GNAI2 GNG3 GNG2 CHRM2 GNG5 GNG4 GNG7 GNG8 AGTR1 CFTR STAT3 RGS11 GTF2A1 GTF2A2 DNM1 DNM3 CTTN ACTN2 GABRG3 GABRG2 WNT5B DAAM1 PFN1 WNT11 FSTL1 GRIN2B GRIN2D GABRB3 GABRB2 GABRB1 PTPRS SERPINE1 SKIL TGIF1 TGIF2 USP9X ATP1B4 SKI TRIM33 SNX3 NEFL CHRDL1 LRRC7 CDON CAMKK1 CAMKK2 WWTR1 RTKN RHPN1 GABRQ TAX1BP3 GABRA1 GABBR2 RHPN2 ROPN1 GABBR1 GRIN1 FZD2 FZD5 WNT5A ATP2A3 ATP2A2 CLTC ATP2A1 CLTB CLTA AP2A1 AP2B1 AP2A2 AP2S1 ROR1 ROR2 AP2M1 PFN2 KLK3 KLK2 SCAI NOX3 KIF14 CIT PKN3 KTN1 PKN2 GOPC PKN1 CFL1 DIAPH3 NF2 PPP1R12B PPP1R14A LIMK2 LIMK1 FMNL3 CBFB FMNL1 FMNL2 GNAL PRC1 RUNX1 DLG2 NBEA DLG3 RASGRF1 GRM1 GRM5 MKNK1 APC GGA3 RAB4B HGF MET CRKL ARF6 ABCA4 ZRANB1 AHCTF1 RANGAP1 ERLEC1 TBXA2R RGS17 RGS19 RGSL1 RGS16 RGS4 SMAD1 RGS20 PRKCH ITGB1 LAMC3 DOCK7 GRB7 LAMC2 PTPRJ SPINT2 ANGPT1 LAMC1 TNS4 TNS3 TEK HGFAC USP8 ITGA3 ITGA2 SPINT1 NTF4 CAMK2B RAPGEF1 LAMA5 CAMK2D LAMA2 CAMK2A LAMA1 LAMA4 HPN LAMA3 LAMB3 LAMB2 RANBP9 LAMB1 CAMK2G RANBP10 MUC20 PTPN2 PRKCG DLG1 DLG4 RALA RALGDS DNAL4 DOCK3 PTPRO RALB HNRNPF KIDINS220 RIT1 RIT2 IL2RG JAK3 DUSP5 DUSP2 DUSP1 DUSP8 DUSP9 DUSP16 DUSP10 PEA15 PPP1CB PHB PPP1R12A SOCS1 CSNK1E DYNLL1 CKAP5 MAPRE1 PAFAH1B1 DYNC1I2 IGF2 RNF111 CLASP1 DYNC1H1 NDE1 FNTA HGS SPTAN1 PRKCQ PPP5C TJP1 PARP1 TJP2 CER1 SIRT6 UBE2D3 APITD1 NRTN YY1 GFRA1 SPTB GFRA2 RUVBL1 GFRA4 SPTBN4 SPTBN5 SPTA1 SPTBN1 SPTBN2 PSPN GDNF PTPRA ARTN ABL1 DTX4 STAT6 MAPK8 KDM4A KDM4B HIST3H3 GSK3A CHUK BAD CASP9 MKRN1 FAM13B FAM13A ARHGDIG ARHGAP39 ARHGAP36 SYDE2 ARHGAP44 SYDE1 ARHGAP42 OPHN1 ARHGAP40 ARHGDIB RALBP1 STARD8 HMHA1 PDE1B BCR PDE1A DEPDC1B PDE2A PDE11A ARHGAP19 PDE10A ARHGAP18 ARHGAP17 ARHGAP15 RHOBTB1 RHOBTB2 ARHGAP12 ARHGAP22 ARHGAP21 RHOT2 ARHGAP20 RHOT1 RACGAP1 SRGAP3 SRGAP1 STARD13 ARHGAP29 ARHGAP28 ARHGAP27 ARHGAP26 ARHGAP25 ARHGAP24 ARHGAP23 ARHGAP33 ARHGAP32 ARHGAP31 ARHGAP30 ARHGAP11A ARHGAP9 PPP2R5E ARHGAP11B ARHGAP8 TRPC7 GDI1 PTGIR TRPC6 GDI2 ARHGAP1 TRPC3 ARHGAP5 PPP2R5B ARHGAP6 PPP2R5A ARHGAP4 TAGAP PTPN11 RAC2 RAC3 RHOG ARAP2 ARAP3 RHOH RHOF RHOC GMIP PTPN6 RHOD RHOB SMAD2 ARHGAP10 DEPDC7 SMAD3 RHOJ RHOU TIAM1 RHOV BDNF RHOQ CHN2 CHN1 MYO9A DLC1 TRIP10 PDE1C SCRIB ADRBK1 PRICKLE1 DVL2 FZD1 FZD3 SMURF2 FZD7 VANGL2 KLB FLT3 PDE3B GRB10 INSR FLT3LG GAB2 FGF19 FGFR4 PMEPA1 BAMBI STRAP MYLIP HDAC11 ANGPTL3 HEY1 HEY2 HDAC4 ABCG1 CETP HDAC5 DLL1 HDAC9 HDAC6 HDAC7 DLL4 NEURL1B HES5 JAG2 APOC4 JAG1 MIB2 APOC1 MIB1 HEYL P4HB NEURL1 CUL5 TRAF6 TAB3 TAB2 TAB1 MAP3K7 SST HTR6 HTR7 HTR1E HTR1F HTR1D HTR2B HTR1A HTR1B HTR2C HTR2A HTR4 HTR5A APOD PPP3CC PPP3R1 GZMB NMT1 AVP MAP2K5 NMT2 IER3 PDGFRB KIT PHLPP2 PHLPP1 PDGFB ESR2 STRN PIK3AP1 HHAT SHH DHH IHH SOX2 SOX3 FRAT1 FRAT2 HRH1 HRH3 SOX17 HRH4 SOX9 SOX6 SOX7 SOX4 SOX13 DKK1 DKK2 DKK4 SFRP1 SFRP2 HECW1 CCDC88C RSPO2 RSPO3 RSPO1 RSPO4 KREMEN1 KREMEN2 WNT9A WNT8A WNT8B WIF1 LEO1 LGR6 LGR5 LGR4 TLE4 TLE3 TLE2 TLE1 CTNNBIP1 PYGO1 PYGO2 TCF7 KLHL12 WNT1 WNT3 WNT4 BCL9L BCL9 CHD8 USP34 CBY1 CDC73 SOST DACT1 AXIN2 LEF1 ZNRF3 SRY TCF7L1 PPP3CA PPP3CB HDAC10 TRRAP NFATC1 SMARCA4 ASH2L MECOM JAK2 PTPRU SOCS6 UBE2M SH2B3 FER TEC FES GRAP RELA KDM1A KDM1B CCND1 FGFBP1 FGFBP2 FGFBP3 MEMO1 DIAPH1 GPR17 LTB4R2 LTB4R KMT2D P2RY1 ESR1 KCTD6 NFKB1 CDK4 NOTCH2 NOTCH3 NOTCH4 RFNG LFNG MFNG TMED2 RAB6A KDM3A HDAC8 RBBP5 KDM4C FOXA1 MYB PGR FKBP4 GATA3 POU2F1 GREB1 AMER1 AXIN1 CXCL12 CITED1 CHD1 NR5A2 TFF1 KANK1 CXXC5 USF2 USF1 ZNF217 EBAG9 WWOX CCR5 CXCR4 RASGRP2 VIPR1 RASGRP1 VIPR2 SCT RASGRP3 RXFP1 RXFP2 CYSLTR1 FOXO6 FOXO4 GPR176 NR4A1 RPS6KB2 PTGDR LHCGR TAAR8 TAAR9 TAAR6 TAAR5 TAAR2 TAAR1 ADCYAP1 ADAM17 EPOR IAPP ADCYAP1R1 CALCA CALCRL CALCB GIPR GPR83 ADRB1 GPR84 ADRB2 CRHR1 CRHR2 GHRHR MC2R CALCR HRH2 DRD1 DRD5 LYN GPR15 YES1 MYL12B MYLK IL6 MC1R RLN2 RLN3 GPR27 MYH11 GPR25 ANXA1 GPR20 ADM PTH1R MC4R INSL3 ACTA2 GPR39 SYK FSHB MYL6 GPR32 AVPR2 GLP2R MYL9 GPBAR1 PTH2R GIP MC3R ADORA2A ADRB3 ADORA2B FSHR CRH MYH9 NPSR1 PTGER4 RAMP2 GFAP RAMP3 GPR45 PTH PTGER2 PRKX PTH2 PTHLH NPS GPR150 GPHA2 P2RY11 SCTR TSHR GHRH ADM2 MC5R VIP RAMP1 GPHB5 HHIP DISP2 ULK3 SCUBE2 DZIP1 EFCAB7 BOC IQCE EVC SPOPL GAS1 GAS8 SPOP EVC2 NOTUM SMAD6 WDR83 PAQR3 BRAP RET GFRA3 PLAT IL17RD RAPGEF2 THBS4 IL5RA THBS3 PDGFD SHC3 RASGRP4 IL5 MAP3K11 RASGEF1A IL3RA IL2RB THBS2 THBS1 GALNT3 TLN1 ATP6V0D1 TACR2 MAP2K1 TACR3 MAP2K2 TAC3 BRAF TACR1 RAF1 TAC1 DRD2 DRD3 DRD4 CSF2RB CSF2RA TCIRG1 OPRD1 ATP6V1E1 ATP6V1E2 ATP6V1G1 ATP6V0B ATP6V0E1 ATP6V1G2 ATP6AP1 MMP2 ATP6V1B2 MMP3 OPRM1 ATP6V0C ATP6V0D2 ATP6V1B1 ATP6V1A S1PR1 NEDD8 ATP6V0A2 ATP6V1H ATP6V0A4 ATP6V0E2 ATP6V1G3 ATP6V1D ATP6V1C1 ATP6V1F ATP6V0A1 ATP6V1C2 C5AR2 C5AR1 C5 CD19 FIGF FLT1 CD55 VEGFB VEGFC PGF P2RY12 IL3 LIN7B P2RY13 P2RY10 P2RY14 LPAR4 P2RY6 P2RY4 LPAR6 SALL4 ADORA3 P2RY2 ADORA1 ATN1 NR2E1 MAF1 SNAI1 SNAI2 COL4A2 COL4A1 COL6A2 COL4A4 ADRA1D ADRA1B COL6A1 ADRA1A COL4A3 COL9A1 COL6A3 COL4A5 COL9A3 COL6A6 COL9A2 COL6A5 ERCC6L ZWILCH BUB1B CASC5 SMC3 CDC20 PLB1 KNTC1 DYNC1LI1 DYNC1LI2 CLIP1 ZW10 MAD1L1 SPARC CDCA8 CSNK2A1 PMF1 CSNK2A2 SKA1 SKA2 DSN1 RAD21 RCC2 NDC80 ZWINT STAG1 KIF18A CSNK2B STAG2 SGOL2 SGOL1 NUF2 SPDL1 NDEL1 NUDC SMC1A DYNLL2 KIF2A INCENP KIF2C KIF2B ITGB3BP MIS12 CENPA SPP1 NSL1 CENPC BUB3 BUB1 DYNC1I1 CLASP2 CENPT CENPU CENPE CENPF CENPH CENPI TAOK1 CENPK CENPL CENPM CENPN B9D2 CENPO CENPP CENPQ SPC24 MAD2L1 SPC25 PLA2G4A NPHP4 MGLL BMP2 AWAT2 BMP10 MMP7 PLG GPAM CAMK4 NFKBIA IKBKG TRIM27 PLK1 STAT5A UBE2D1 STAT5B SOCS3 IRS1 LEP IRS2 CDK1 TIAL1 TIA1 RBFOX2 ESRP2 FLRT3 ACVRL1 BMPR2 AMHR2 AMH NOG GDF2 SMAD9 SMAD5 GREM2 ZFYVE16 BMPR1B BMPR1A PLXNB1 NUP107 NRP2 PPP2R1B PPP2R1A PRKACG PRKACA PRKACB SEC13 NUP133 RDH11 PPP2R5D PIP5K1A PIP5K1B PIP5K1C FASN NUP160 PPP2CA PPP2CB NUP85 SMPD3 NUP43 PCK1 SMPD2 RANBP2 OR11H2 OR11H1 OR2M7 OR11H4 OR2M5 OR2M4 OR2M3 OR1K1 OR2M2 OR4K17 OR4Q3 OR2AE1 OR11H6 OR2L8 OR1J4 OR11G2 OR2L5 OR1J2 OR2L3 NUP37 OR1J1 OR2L2 OR4P4 OR10AD1 OR5R1 OR6T1 OR4K15 OR4K14 PPARG OR4K13 OR13J1 OR1I1 OR2K2 OR6S1 RAPGEF3 OR5M11 OR5M10 PPARD OR10D3 RAPGEF4 OR8B12 OR14K1 OR2J3 OR4N5 OR2J2 OR4N4 OR2J1 OR4N2 OR5P3 OR5P2 OR10C1 OR10J1 OR11L1 OR10J3 AGRN OR10J5 OR5W2 OR6Y1 OR52B2 OR52B6 OR1N2 OR1N1 OR5V1 OR6X1 OR52A1 OR52A5 OR10H1 OR10H3 OR10H2 OR10H5 OR10H4 CRABP1 OR1M1 STAM OR4S2 DHRS3 OR4S1 DHRS4 ADRBK2 ALDH1A3 OR2AG1 SDR16C5 DHRS9 OR2AG2 ALDH1A2 OR10G2 RDH10 OR14A16 RDH16 OR1L8 OR10G4 RDH5 ATF1 RDH14 OR1L6 RDH13 OR10G3 SH3GL3 STAM2 ATF2 ALDH8A1 OR1L4 NAB1 OR1L3 NAB2 OR1L1 CHD4 OR5T3 NTRK3 ELK1 OR5T2 RPS6KA3 OR5T1 LYL1 OR6V1 RPS6KA5 OR10G6 RPS6KA2 OR10G8 RPS6KA1 OR10G7 OR10G9 EP300 OR52W1 JUNB DUSP4 OR1S2 MEF2A OR1S1 OR13D1 MEF2C DUSP3 OR14C36 RAP1A TCF12 OR5AS1 FOS OR2T8 CTBP2 VRK3 OR2T7 F3 OR2T6 AES DUSP6 OR2T5 DNM2 OR2T4 DUSP7 OR2T3 OR2T2 ARC OR13C9 CREB1 OR2T1 VGF OR13C8 MAPKAPK2 OR4X2 SGK1 SP1 TRIB1 OR2L13 OR4X1 TPH1 OR9A4 RRAD OR51T1 SRF OR9A2 ASCL1 OR13C3 MAPK7 OR13C2 MAPK1 OR13C5 MEF2D OR13C4 MAPK3 EGR1 OR5AR1 EGR2 OR2S2 JUND OR1Q1 OR51S1 EGR3 EGR4 OR4A47 MAPK14 OR5B21 FOSL1 REEP1 REEP5 MAPK11 REST REEP4 REEP3 CDK5 REEP2 ID2 REEP6 ID1 OR13A1 ID4 OR7E24 FOSB OR7A10 ID3 OR14J1 CDK5R2 OR13H1 CDK5R1 OR2Y1 OR56B1 OR8D4 OR8D2 OR56B4 OR8D1 OR7A17 OR6C70 ERBB2IP OR6C76 OR6C75 HSP90AA1 CDC37 OR6C74 OR13G1 ERBB2 OR14I1 OR10A7 OR56A5 OR7A5 OR10A2 OR10A4 OR56A4 OR10A3 OR56A3 OR10A6 OR10A5 OR56A1 OR6C65 OR2W3 OR8B8 OR2W1 OR8B4 OR8B3 OR6C68 OR13F1 OR8B2 OR12D3 OR12D2 OR5AU1 OR51V1 OR2V2 OR2V1 OR11A1 OR8A1 OR7G2 OR8I2 OR7G1 OR9K2 OR52N1 OR52N5 OR52N4 OR52N2 OR51L1 SDC4 SDC2 OR5D18 SDC3 OR10W1 OR2A42 OR5D16 OR5B3 APOM OR5B2 OR5D14 OR8H3 APOE OR5D13 APOB OR8H2 OR8H1 OR52M1 OR10V1 OR4C12 OR2AT4 OR6C6 OR4C11 OR6C4 OR5A2 OR8G5 OR6C3 OR4C16 OR5AK2 OR5A1 SDC1 OR6C2 OR4C15 OR6C1 OR4C13 OR8G1 OR9I1 OR10T2 OR51J1 OR52L1 OR7D4 OR6B3 OR6B2 FGFRL1 OR6B1 OR7D2 STMN1 FLRT2 OR2A25 OR51I2 FLRT1 CILP OR10S1 OR52K2 IRS4 OR51I1 ADAP1 CSN2 OR52K1 MST1R PDE3A OR4D11 MXD4 OR2Z1 OR4D10 OR2A12 OR6A2 OR9G4 HSD17B1 OR7C2 OR7C1 OR9G1 OR2A14 OR2A1 OR4E2 OR51Q1 GCG OR4D9 OR5AP2 OR5B12 OR4D6 OR4D5 OR5B17 OR4D2 OR4D1 OR5F1 HNRNPM OR10Z1 OR52R1 OR4C6 OR4C5 OR3A3 OR3A2 OR4A15 OR4C3 OR14A2 OR3A1 OR4A16 OR8K5 OR8K3 PTBP1 OR8K1 OR5AN1 OR4B1 OR4C46 OR8J3 OR6F1 OR8J1 OR51M1 OR10X1 OR4A5 OR7G3 OR5C1 OR1C1 OR5K4 OR5K3 OR5K2 HNRNPH1 OR51D1 OR5K1 OR6M1 OR2T12 OR2T10 OR2T11 OR5H15 OR5H14 PDHA2 PDE8B PDE8A PDHA1 OR2D3 OR2D2 OR1B1 GNAQ OR52E4 OR5J2 OR52E2 HNRNPA1 OR5AC2 OR52E8 OR52E6 OR52E5 OR2C3 OR1A2 OR6K6 OR1A1 OR2C1 OR51B2 OR6K3 OR6K2 OR5I1 VPS29 OR52D1 OR9Q2 VPS26A OR9Q1 VPS35 OR2AK2 TMED5 WLS GRK5 GRK6 OR51B6 OR51B5 OR51B4 OR2B6 OR4F6 OR4F5 OR5H6 OR2B3 STK4 OR10K2 OR4F4 STK3 SAV1 OR2B2 OR10K1 LATS1 OR4F3 MOB1B OR5H2 MOB1A OR5H1 LATS2 AMOTL2 OR6J1 ACTB OR2AJ1 AMOTL1 OR51A4 HIST1H2AE OR2A7 OR51A2 HIST1H2AD HIST3H2BB OR2A5 HIST1H2AC OR2A4 OR51A7 HIST1H2AB OR2A2 HIST1H2AJ RTP4 RTP5 OR52J3 HIST2H3A RTP2 OR51H1 HIST1H2BF HIST1H2BE RTP3 HIST1H2BH RTP1 OR1G1 HIST1H2BG OR4M2 HIST2H3D HIST1H2BB OR4M1 HIST1H2BA OR10R2 HIST2H3C OR10AG1 HIST1H2BD OR6Q1 HIST1H2BC OR8U1 H2AFB1 PDE4A OR51G2 OR52I2 HIST1H3J OR51G1 OR52I1 HIST1H3A OR1F1 HIST1H3F HIST1H3G PDE4D HIST1H3H OR2H2 HIST1H3I PDE4C OR2H1 OR4L1 HIST1H3B HIST1H3C OR10Q1 HIST1H3D OR6P1 OR2B11 HIST1H3E OR2AP1 H3F3B OR51F2 HIST1H4K OR2G6 OR51F1 ADH4 HIST1H4L OR5M9 H3F3A OR52H1 H2BFS OR5M8 ST3GAL4 HIST1H4A OR2G3 OR1E2 ST3GAL6 OR4K5 HIST1H4B CGA HIST1H4H OR2G2 OR1E1 HIST1H4I OR5M3 HIST1H4J OR4K2 HIST1H4C OR4K1 OR5M1 ST3GAL3 HIST1H4D HIST1H4E OR10P1 OR2T34 OR8S1 EZH2 OR2T35 HIST1H4F OR2T33 HIST2H2AA3 GSK3B OR4F29 HIST2H2AA4 OR4F21 OR1D5 NEDD4L OR2T27 OR51E1 CHD3 OR1D2 HIST2H2AC OR2F2 OR2F1 OR2T29 OR51E2 H2AFJ OR5L2 OR6N2 OR5L1 OR6N1 TBP OR4F17 EED OR4F16 H2AFZ OR4F15 NCOR2 PDE7B H2AFX PDE7A NCOR1 H2AFV PLIN1 HIST2H2BE KAT2B KAT2A HIST4H4 LDLR HIST1H2BN HIST1H2BM HDAC2 HIST1H2BO NR1H2 HIST1H2BJ HDAC1 HIST1H2BI HIST1H2BL HIST1H2BK NPY NR1H3 HIST2H4A HIST2H4B MTA1 RBBP4 PPP1CC CYSLTR2 POLR2E POLR2F POLR2H RBBP7 MTA2 MTA3 POLR2K POLR2L MBD3 CSNK1G2 SUZ12 WWP1 GATAD2B GATAD2A RAB4A IL1RL1 IL33 PRKG2 PTPN18 APOA2 APOA1 APOA4 PDHB DNER DLGAP5 IKBKB FCER2 TACC3 POGLUT1 TTR PLXND1 WWC1 POFUT1 UGT1A3 RIPK2 IRAK4 BCO2 DTX1 BCO1 DTX2 CNTN1 TLR9 FLT4 YBX1 MDK PTCRA ELF3 DLK1 APOC3 IRAK1 S100B APOC2 SAA1 MYD88 PDK4 PDK3 YWHAB HSPB1 PRKCE PDK2 PSMD8 PSMD9 PDK1 PSMD6 SH3KBP1 SRC PDHX XPO1 CPT1A PSMD7 PTPRK CPT1B PSMD4 LRIG1 CSK TIAM2 PSMD5 EPS15 PSMD2 AAMP PSMD3 PAG1 AKT1 SH3GL1 ADAM10 PSMD1 EPS15L1 PTPN12 EPN1 PRKCD ADAM12 PRKCA YWHAZ SPRY2 PSMA5 SPRY1 ARHGEF7 PSMA6 PSMA3 PTPN3 LHB PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 UBA52 PSMD10 PSMB11 PSMD12 PSMD11 RPS27 PSMD14 PSMD13 PSMA7 PSMB10 FZD10 PSMA8 CRHBP PDYN RBP3 PSMB6 AGTR2 FPR3 PSMB7 RDH12 NPBWR1 PSMB4 NPBWR2 NGFR HCRT ARHGDIA PSMB5 NAPEPLD PSMB2 UBB GPR18 GPRC6A PSMB3 UCN3 UCN2 ADH1C UBC GPR37 GPR35 PSMB1 WNT9B ADH1A PSMF1 GPR31 PROKR1 RPS27A PROKR2 WNT7B ZDHHC21 GPR55 WNT7A SHFM1 GPR68 PSMB8 GPR65 FNTB PSMB9 PSMC5 UTS2 ECE1 PSMC6 RLBP1 PSMC3 PRLHR PSMC4 HCRTR2 PSMC1 LRRK2 HCRTR1 NR3C1 PSMC2 APLN ARHGAP35 PELP1 OPN1MW2 EIF4G1 NRG1 NPFFR2 NPFFR1 ARAP1 NRG2 TAS2R20 OXER1 DOK1 TAS2R10 SFPQ NRG3 NPFF NRG4 TAS2R13 KHDRBS1 TAS2R14 KHDRBS2 PTGES3 TAS2R16 KHDRBS3 MYO7A EPAS1 TAS2R19 KEL HIF1A GPNMB TAS2R40 TAS2R41 STAP2 PTPN1 TAS2R42 SRMS TAS2R43 KLC1 PTK6 TAS2R46 KLC4 LPAR1 KLC3 LPAR2 KLC2 LPAR3 PENK TAS2R30 TAS2R31 TAS2R38 TAS2R39 RPE65 LPAR5 PPP1R1B GNRH2 GNRH1 PNLIP TAS2R60 PTGDR2 MLN GNRHR OXGR1 LPL TAS2R50 GAL HSD17B6 PRLH XK RGS5 RGS2 RGS3 TYK2 RGS1 RGS8 CASR CAMKMT IL6R PCP2 IFT172 ARHGEF25 BTRC MCHR2 GRK1 SKP1 BTK DYNC2H1 WNT6 ARHGEF6 GRK7 RPGRIP1L LRP10 RBX1 WNT2 OXT LRP12 SQSTM1 IFT88 GRM3 ADCY9 GLP1R ADGRE1 PRKAR1B SMO ADGRE2 GRM2 PRKAR1A GRM4 GPR161 PACKAGING OF TELOMERE ENDS%REACTOME%R-HSA-171306.2 Packaging Of Telomere Ends TINF2 TERF2IP HIST1H2AE HIST1H2AD HIST3H2BB HIST1H2AC ACD HIST1H2AB HIST1H2AJ HIST1H2BF HIST1H2BE HIST1H2BH HIST1H2BG HIST1H2BB HIST1H2BA HIST1H2BD HIST1H2BC H2AFB1 HIST3H3 TERF1 TERF2 POT1 HIST1H4K HIST1H4L H2BFS HIST1H4A HIST1H4B HIST1H4H HIST1H4I HIST1H4J HIST1H4C HIST1H4D HIST1H4E HIST1H4F HIST2H2AA3 HIST2H2AA4 HIST2H2AC H2AFJ H2AFZ H2AFX H2AFV HIST2H2BE HIST4H4 HIST1H2BN HIST1H2BM HIST1H2BO HIST1H2BJ HIST1H2BI HIST1H2BL HIST1H2BK HIST2H4A HIST2H4B CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A%REACTOME%R-HSA-174184.2 Cdc20:Phospho-APC C mediated degradation of Cyclin A PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 BUB1B CCNA2 CCNA1 UBA52 CDC20 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 ANAPC15 ANAPC16 PSMB6 ANAPC7 PSMB7 UBE2C UBE2E1 PSMB4 UBE2D1 ANAPC10 PSMB5 ANAPC11 PSMB2 UBB CDC23 PSMB3 CDC26 CDC27 UBC CDC16 PSMB1 CDK1 ANAPC4 PSMF1 ANAPC5 ANAPC1 RPS27A ANAPC2 SHFM1 PSMB8 PSMB9 PSMC5 PSMC6 PSMC3 PSMC4 BUB3 PSMC1 PSMC2 MAD2L1 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 GLYCEROPHOSPHOLIPID CATABOLISM%REACTOME DATABASE ID RELEASE 72%6814848 Glycerophospholipid catabolism ENPP6 PNPLA6 GDPD1 GDPD3 GDPD5 PNPLA7 GDE1 INTERLEUKIN-36 PATHWAY%REACTOME%R-HSA-9014826.1 Interleukin-36 pathway IL36RN IL36G IL1F10 IL1RL2 IL36A IL36B SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX)%REACTOME%R-HSA-2162123.1 Synthesis of Prostaglandins (PG) and Thromboxanes (TX) PTGIS PTGES PTGR2 CBR1 PTGES2 PTGES3 FAM213B HPGD HPGDS PTGS2 PTGDS PTGS1 AKR1C3 TBXAS1 CYP8B1 CLEC7A INFLAMMASOME PATHWAY%REACTOME%R-HSA-5660668.1 CLEC7A inflammasome pathway IL1B NFKB1 PYCARD MALT1 RELA CASP8 DNA DAMAGE REVERSAL%REACTOME DATABASE ID RELEASE 72%73942 DNA Damage Reversal ALKBH5 FTO MGMT ASCC2 ASCC3 ASCC1 ALKBH3 ALKBH2 FGFRL1 MODULATION OF FGFR1 SIGNALING%REACTOME%R-HSA-5658623.3 FGFRL1 modulation of FGFR1 signaling SPRED2 SPRED1 FGFRL1 FGF2 FGF18 FGF23 FGF3 FGF22 FGF10 FGF4 SIGNALING BY NOTCH3%REACTOME DATABASE ID RELEASE 72%9012852 Signaling by NOTCH3 MAML2 NCSTN MAML1 DLGAP5 ADAM10 APH1B STAT1 TACC3 RBPJ PLXND1 WWC1 HES1 YBX1 PTCRA EGF SNW1 MAML3 EGFR MAMLD1 UBA52 PSENEN NOTCH3 CREBBP HEY1 HEY2 EP300 DLL1 KAT2B KAT2A FABP7 DLL4 NEURL1B HES5 UBB JAG2 JAG1 MIB2 MIB1 UBC HEYL WWP2 NEURL1 RPS27A PSEN2 PSEN1 PBX1 APH1A NOTCH1 CELL-CELL JUNCTION ORGANIZATION%REACTOME%R-HSA-421270.4 Cell-cell junction organization CDH1 PVR CLDN2 CDH9 CLDN1 CTNNA1 CDH8 CDH7 CDH6 CLDN22 CLDN20 CDH3 CLDN23 CLDN11 CLDN5 CLDN6 JUP CLDN10 CLDN4 CLDN3 CLDN15 CLDN14 CLDN9 CLDN8 CDH10 CLDN12 CLDN7 CDH11 CTNNB1 CLDN19 CDH12 CLDN18 CDH13 ANG CLDN17 CLDN16 CDH17 CDH18 PARD6G PARD6B CDH24 CADM3 CADM2 CADM1 MPP5 INADL PVRL4 PVRL3 PVRL1 CRB3 CDH4 CDH2 CDH15 PVRL2 F11R PRKCI PARD6A PARD3 CTNND1 CDH5 SDK1 SDK2 DEFECTIVE HEXB CAUSES GM2G2%REACTOME%R-HSA-3656248.1 Defective HEXB causes GM2G2 HEXB BIOSYNTHESIS OF DPAN-3-DERIVED 13-SERIES RESOLVINS%REACTOME%R-HSA-9026403.1 Biosynthesis of DPAn-3-derived 13-series resolvins ALOX5 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 72%2691230 Signaling by NOTCH1 HD Domain Mutants in Cancer ADAM10 DLL1 DLL4 NEURL1B JAG2 ADAM17 UBB JAG1 MIB2 MIB1 UBC NEURL1 RPS27A UBA52 NOTCH1 ION HOMEOSTASIS%REACTOME DATABASE ID RELEASE 72%5578775 Ion homeostasis ATP1A2 CAMK2D ATP1A1 CAMK2A SRI PLN TNNI3 CAMK2G ATP2B4 ITPR1 ATP2B3 ITPR2 ATP2B2 ITPR3 ATP2B1 SLC8A3 FKBP1B PRKACA KCNJ11 SLC8A1 SLC8A2 SLN ATP1B3 ATP1B2 ATP1B1 STIM1 ORAI2 ORAI1 DMPK FXYD4 FXYD3 FXYD2 FXYD1 FXYD7 FXYD6 RYR1 RYR2 AHCYL1 ATP2A3 ATP2A2 ATP2A1 RYR3 NOS1 CLIC2 TRPC1 ABCC9 TRDN ASPH ATP1A4 CAMK2B ATP1A3 LINOLEIC ACID (LA) METABOLISM%REACTOME%R-HSA-2046105.1 Linoleic acid (LA) metabolism ELOVL5 ELOVL2 ELOVL3 FADS2 ACSL1 ABCD1 ELOVL1 FADS1 RNA POLYMERASE II TRANSCRIBES SNRNA GENES%REACTOME%R-HSA-6807505.2 RNA polymerase II transcribes snRNA genes GTF2B GTF2A1 GTF2A2 GTF2E1 GTF2E2 POLR2E POLR2F POLR2H POLR2K POLR2L SNAPC5 SNAPC1 SNAPC2 SNAPC3 SNAPC4 ZNF143 PCF11 INTS1 INTS3 TAF9 INTS2 INTS5 INTS4 INTS7 INTS6 INTS9 INTS8 INTS12 INTS10 ICE1 ICE2 SSU72 NABP2 NABP1 TAF13 TAF8 ELL2 CCNK ELL3 ZC3H8 CCNT2 TAF11 RPRD2 CCNT1 RPAP2 ASUN VWA9 CPSF3L SP1 RPRD1B RPRD1A POU2F2 NCBP1 TAF6 NCBP2 TAF5 SUPT4H1 SUPT5H GTF2F1 GTF2F2 CDK7 POLR2A POLR2B POLR2C POLR2D POLR2G POLR2I POLR2J AK6 PHAX TBP CDK9 SRRT ELL POU2F1 OVARIAN TUMOR DOMAIN PROTEASES%REACTOME DATABASE ID RELEASE 72%5689896 Ovarian tumor domain proteases OTUD7A ZRANB1 RIPK2 TP53 ESR1 OTUD7B TNFAIP3 NOD1 NOD2 UBA52 RIPK1 OTUD5 VCPIP1 TNIP2 IKBKG APC OTUB1 OTUB2 IFIH1 RNF135 TNIP1 MAVS TNIP3 UBE2D1 RHOA UBB TRIM25 UBC CDK1 RPS27A DDX58 RNF128 OTUD3 VCP TRAF6 PTEN YOD1 TRAF3 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME%R-HSA-354194.1 GRB2:SOS provides linkage to MAPK signaling for Integrins RAP1B FGB FGA FN1 VWF PTK2 RAP1A FGG ITGA2B ITGB3 APBB1IP SOS1 SRC TLN1 OPIOID SIGNALLING%REACTOME DATABASE ID RELEASE 72%111885 Opioid Signalling CAMK2D PDE4B CAMK2A PRKAR2B PRKAR2A PRKCD PRKCA CAMK2G PRKCG GNAL ITPR1 NBEA ITPR2 ITPR3 CAMK4 PPP2R1B ADCY4 PPP2R1A ADCY3 PRKACG ADCY2 PRKACA ADCY1 PRKACB ADCY8 ADCY7 ADCY6 ADCY5 PDE1C ADRBK1 GNAT2 PDYN GNAT3 PPP2R5D GNAT1 PDE4A PLCB3 PLCB4 PLCB1 PLCB2 PDE4D KPNA2 CREB1 PDE4C GNAZ GNG10 PPP3CC MAPK1 PPP3R1 GNG12 PPP2CA GNG11 OPRM1 PPP2CB GNG13 GNAO1 GNB2 GNB1 GNB4 CDK5 GNB3 GNB5 GNGT1 GNGT2 CAMKK1 CAMKK2 POMC PDE1B PPP1R1B PDE1A PLA2G4A PPP3CA GNAI3 PPP3CB GNAI1 GNAI2 GNG3 GNG2 AHCYL1 GNG5 GNG4 GNG7 GNG8 PRKX ADCY9 PRKAR1B PPP1CA PRKAR1A CAMK2B UNFOLDED PROTEIN RESPONSE (UPR)%REACTOME%R-HSA-381119.2 Unfolded Protein Response (UPR) DIS3 PPP2R5B CXCL8 EDEM1 SYVN1 CALR DCP2 PARN CCL2 EIF2S2 EIF2S1 EXOSC7 EIF2S3 ACADVL ATF3 EXOSC6 EXOSC5 EXOSC4 SULT1A3 EXOSC9 EXOSC8 EXOSC3 EXOSC2 EXOSC1 HSPA5 SEC31A GSK3A NFYA NFYB NFYC EIF2AK3 HERPUD1 SHC1 MBTPS1 ERN1 CREB3 CREB3L4 CREB3L1 MBTPS2 CREB3L2 CEBPB CREB3L3 CEBPG CUL7 DCTN1 CREBRF FKBP14 DCSTAMP GOSR2 SRPR CXXC1 PLA2G4B ADD1 MYDGF EXTL2 EXTL1 SERP1 TATDN2 LMNA DNAJB9 SSR1 EXTL3 TSPYL2 ZBTB17 DDIT3 KLHDC3 ATF6 WFS1 DDX11 HSP90B1 ATF4 GFPT1 WIPI1 PDIA6 YIF1A IGFBP1 ARFGAP1 PDIA5 DNAJC3 CTDSP2 DNAJB11 SRPRB TPP1 PREB ASNS HDGF HYOU1 KDELR3 TLN1 KHSRP ATP6V0D1 PRESYNAPTIC FUNCTION OF KAINATE RECEPTORS%REACTOME%R-HSA-500657.1 Presynaptic function of Kainate receptors GNG11 GNG13 GNB2 GNB1 GNB4 GNB3 GNG3 PLCB3 GNG2 GNG5 GNB5 GNG4 GNG7 GNG8 PLCB1 GNGT1 PLCB2 GNGT2 GRIK3 GNG10 GNG12 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG%REACTOME%R-HSA-3359469.1 Defective MTR causes methylmalonic aciduria and homocystinuria type cblG MTRR MTR REELIN SIGNALLING PATHWAY%REACTOME DATABASE ID RELEASE 72%8866376 Reelin signalling pathway DAB1 RELN VLDLR SH3KBP1 FYN HH MUTANTS THAT DON'T UNDERGO AUTOCATALYTIC PROCESSING ARE DEGRADED BY ERAD%REACTOME%R-HSA-5362768.1 Hh mutants that don't undergo autocatalytic processing are degraded by ERAD PSMD3 OS9 PSMD1 PSMA5 PSMA6 PSMA3 SYVN1 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 UBA52 PSMD10 PSMB11 PSMD12 SHH PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 UBB PSMB3 UBC PSMB1 PSMF1 RPS27A SHFM1 PSMB8 PSMB9 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 ERLEC1 PSMD8 VCP PSMD9 PSMD6 PSMD7 SEL1L PSMD4 PSMD5 DERL2 PSMD2 PPARA ACTIVATES GENE EXPRESSION%REACTOME DATABASE ID RELEASE 72%1989781 PPARA activates gene expression ARNTL TBL1X ARNT2 THRAP3 CDK19 MED13L CCNC TBL1XR1 CYP1A1 FAM120B CLOCK PEX11A SREBF2 HMGCS2 HMGCS1 TXNRD1 APOA2 APOA1 GPS2 APOA5 CARM1 MED19 MED16 MED15 MED18 MED17 MED12 RGL1 MED11 MED14 ABCB4 MED13 UGT1A9 AGT MED10 AHR MED27 CD36 MED26 MED29 NCOA1 MED28 MED23 MED22 NCOA2 PPARGC1A CREBBP MED25 NCOA6 MED24 PPARGC1B NCOA3 MED21 ABCA1 MED20 RXRB PPARG RXRA PPARA ESRRA CPT1A TIAM2 CDK8 CYP4A11 SLC27A1 TRIB3 FADS1 TGS1 HELZ2 SMARCD3 FABP1 NRF1 EP300 NPAS2 MED30 RORA MED31 CHD9 ACADM CPT2 ACSL1 SP1 CYP7A1 ALAS1 NFYA FDFT1 NR1D1 FHL2 NFYB NFYC GRHL1 ME1 ARNT TNFRSF21 NCOR2 NCOR1 HDAC3 MTF1 AHRR PLIN2 ANGPTL4 GLIPR1 SULT2A1 ANKRD1 MED1 MED8 NR1H2 MED9 MED4 MED6 NR1H4 MED7 G0S2 NR1H3 CRISTAE FORMATION%REACTOME DATABASE ID RELEASE 72%8949613 Cristae formation ATP5G2 ATP5G1 ATP5F1 ATP5C1 APOO SAMM50 MINOS1 HSPA9 APOOL MTX1 MTX2 DNAJC11 IMMT TMEM11 ATP5J2 ATP5S MT-ATP6 ATP5J ATP5I ATP5H ATP5O ATP5L ATP5B ATP5E ATP5D ATP5A1 CHCHD3 CHCHD6 ATP5G3 MT-ATP8 C19orf70 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL%REACTOME DATABASE ID RELEASE 72%198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell LILRA1 LILRA2 LILRA4 CDH1 LILRA5 ITGB2 NCR3LG1 LAIR2 ITGAL COLEC12 MICA MICB NPDC1 LILRB1 LILRB4 LILRB5 PVR CD96 CD8A KLRF1 CD300C KLRB1 KIR2DL1 KIR2DL2 KIR2DL3 KIR2DL4 KLRC1 TREM1 CD99 CD300LB CRTAM IGKV1-12 CD8B KIR2DS2 ULBP1 NCR2 CD300E ULBP3 AMICA1 KLRG1 CD40LG IGKV2D-28 IGKV4-1 IGKV2D-30 CD33 IGKV3-11 LILRA3 CD3G LAIR1 FCGR3A IGKV2-28 LILRB2 LILRB3 CD81 IGKV3D-20 ICAM1 CD300A OSCAR SELL HLA-A B2M CD19 C3 FCGR1A TREM2 KLRK1 IGKV5-2 TYROBP KLRD1 VCAM1 TRAV19 CD3E IFITM1 CD3D CXADR HLA-B TREML1 HLA-C TREML4 TREML2 HLA-F HLA-G CD200R1 HLA-E HCST KIR3DL1 KIR3DL2 SIGLEC1 SIGLEC8 SIGLEC7 SIGLEC6 SIGLEC9 CLEC4G CD300LD CD300LF CD300LG CD160 ITGB7 PIANP ITGA4 CLEC2B FCGR2B CLEC2D PVRL2 ICAM2 ICAM3 ICAM4 SIGLEC5 ICAM5 CD226 CD1D CD1C CD1B CD1A SLAMF7 SLAMF6 SIGLEC12 SIGLEC11 SH2D1A SIGLEC10 SH2D1B PILRB PILRA ITGB1 RAET1E CD200 CD22 NCR1 NCR3 LILRA6 REGORAFENIB-RESISTANT PDGFR MUTANTS%REACTOME%R-HSA-9674403.1 Regorafenib-resistant PDGFR mutants PDGFRA SIGNALING BY NOTCH1%REACTOME DATABASE ID RELEASE 72%1980143 Signaling by NOTCH1 CUL1 NCSTN ADAM10 APH1B TBL1X ARRB2 NBEA CCNC UBA52 PSENEN NUMB TBL1XR1 ARRB1 ITCH EP300 ADAM17 UBB UBC RPS27A MYC NOTCH1 MAML2 TLE4 DNER MAML1 TLE2 TLE1 RBPJ HES1 DTX1 DTX2 CNTN1 HIF1A SNW1 MAML3 DLK1 MAMLD1 NCOR2 CREBBP HDAC11 HEY1 NCOR1 HDAC3 HEY2 HDAC4 HDAC5 DLL1 HDAC10 HDAC9 KAT2B HDAC6 KAT2A HDAC7 DLL4 NEURL1B HES5 JAG2 JAG1 MIB2 MIB1 HDAC8 DTX4 HEYL NEURL1 HDAC2 SKP1 HDAC1 RBX1 PSEN2 PSEN1 APH1A CDK8 REGULATION OF FOXO TRANSCRIPTIONAL ACTIVITY BY ACETYLATION%REACTOME%R-HSA-9617629.1 Regulation of FOXO transcriptional activity by acetylation TXN EP300 FOXO3 SIRT1 SIRT3 KAT2B TXNIP FOXO1 CREBBP FOXO4 LOSS OF FUNCTION OF TGFBR1 IN CANCER%REACTOME%R-HSA-3656534.1 Loss of Function of TGFBR1 in Cancer SMAD2 TGFB1 SMAD3 TGFBR1 TGFBR2 FKBP1A DEFECTIVE CYP7B1 CAUSES SPASTIC PARAPLEGIA 5A, AUTOSOMAL RECESSIVE (SPG5A) AND CONGENITAL BILE ACID SYNTHESIS DEFECT 3 (CBAS3)%REACTOME DATABASE ID RELEASE 72%5579013 Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3) CYP7B1 RESPONSE OF EIF2AK4 (GCN2) TO AMINO ACID DEFICIENCY%REACTOME%R-HSA-9633012.2 Response of EIF2AK4 (GCN2) to amino acid deficiency RPL26 RPL29 RPL10L RPS4X RPL10A RPL28 RPS3A RPL23A FAU RPL41 RPL3L RPL10 RPL12 RPL13A RPL11 RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL27A RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS15 RPS14 RPS17 RPS16 DDIT3 RPS19 RPL18A RPL36AL ATF4 RPS18 RPLP1 RPS11 RPS10 RPLP0 RPS13 RPS12 ASNS RPLP2 RPL7A TRIB3 RPS27L UBA52 RPL37A RPS26 RPS25 RPS28 ATF2 RPS27 RPL36A RPS29 EIF2S2 RPS20 RPL35A EIF2S1 RPS21 RPS24 EIF2S3 RPS23 ATF3 RPL22L1 EIF2AK4 RPS4Y2 RPS4Y1 RPS27A IMPACT RPL26L1 RPL4 RPL39L CEBPB CEBPG RPL5 RPL30 GCN1L1 RPL3 RPL32 RPL31 RPL34 RPL8 RPL9 RPL6 RPL7 RPL36 RPL35 RPL38 RPL37 RPL39 RPS15A RPL21 RPL23 RPL22 RPL24 RPL27 EICOSANOID LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 72%391903 Eicosanoid ligand-binding receptors LTB4R PTGIR PTGER1 PTGER3 PTGDR2 PTGDR CYSLTR2 OXER1 PTGER4 PTGFR PTGER2 GPR17 CYSLTR1 TBXA2R LTB4R2 MET ACTIVATES PTPN11%REACTOME%R-HSA-8865999.1 MET activates PTPN11 GAB1 HGF PTPN11 MET CELL-EXTRACELLULAR MATRIX INTERACTIONS%REACTOME DATABASE ID RELEASE 72%446353 Cell-extracellular matrix interactions PARVB LIMS2 FLNA RSU1 LIMS1 ILK ACTN1 PXN VASP ITGB1 FBLIM1 ARHGEF6 FLNC TESK1 FERMT2 DUAL INCISION IN GG-NER%REACTOME%R-HSA-5696400.1 Dual Incision in GG-NER POLK RPA1 POLE RPA2 POLD3 POLD4 RFC1 RPA3 POLD1 POLD2 RFC5 RFC3 RFC4 DDB2 RFC2 XPA GTF2H1 UBA52 GTF2H2 GTF2H3 CHD1L GTF2H4 GTF2H5 ERCC3 ERCC2 CUL4A POLE4 ERCC4 ERCC1 POLE2 UBB POLE3 ERCC5 UBC PARP1 CUL4B PARP2 RPS27A DDB1 RBX1 PCNA REGULATION OF INSULIN SECRETION%REACTOME%R-HSA-422356.3 Regulation of insulin secretion KCNG2 PRKAR2B AKAP5 PRKAR2A PRKCA STXBP1 GNAS STX1A VAMP2 ADRA2C ADRA2A ITPR1 ITPR2 CACNA2D2 ITPR3 GNA14 GNA15 PRKACG PRKACA PRKACB ADCY8 GNA11 ADCY6 ADCY5 KCNJ11 MARCKS RAP1A PLCB3 SLC2A1 SLC2A2 PLCB1 PLCB2 ACSL4 GNG10 ACSL3 GCG KCNC2 GNG12 GNG11 KCNS3 GNG13 ABCC8 GNB2 GNB1 GNB4 GNB3 GNB5 INS IQGAP1 GNGT1 CHRM3 GNGT2 CD36 CACNA1A CACNA1D CACNA1C CACNA1E CACNB2 CACNB3 GNAI1 GNAI2 SYT5 GNG3 GNG2 AHCYL1 GNG5 RAPGEF3 GNG4 GNG7 GNG8 GNAQ FFAR1 RAPGEF4 KCNB1 GLP1R PRKAR1B SNAP25 PRKAR1A ACYL CHAIN REMODELLING OF PS%REACTOME%R-HSA-1482801.3 Acyl chain remodelling of PS PLA2G4B OSBPL8 PLA2G4A OSBPL5 LPCAT4 LPCAT3 PLA2G16 PLA2G10 PLA2G1B PLA2R1 PLA1A PLA2G2F OSBPL10 PLA2G2D PLA2G5 PLA2G2E PLA2G12A PLA2G4F PLA2G2A PLA2G4D MBOAT1 DNA STRAND ELONGATION%REACTOME DATABASE ID RELEASE 72%69190 DNA strand elongation LIG1 RPA1 RPA2 POLD3 POLD4 RFC1 RPA3 POLD1 GINS1 POLD2 GINS2 POLA1 RFC5 GINS3 POLA2 DNA2 GINS4 MCM7 RFC3 MCM8 RFC4 RFC2 MCM3 MCM4 MCM5 MCM6 MCM2 PRIM2 PRIM1 CDC45 FEN1 PCNA AGMATINE BIOSYNTHESIS%REACTOME%R-HSA-351143.1 Agmatine biosynthesis AZIN2 AGMAT RUNX2 REGULATES CHONDROCYTE MATURATION%REACTOME DATABASE ID RELEASE 72%8941284 RUNX2 regulates chondrocyte maturation HDAC4 IHH CBFB GLI2 VISUAL PHOTOTRANSDUCTION%REACTOME%R-HSA-2187338.1 Visual phototransduction SDC4 SDC2 SDC3 PRKCA APOM APOE APOB DHRS3 OPN1SW DHRS9 FNTA RDH10 RDH16 PLB1 RDH5 SDC1 OPN1LW PRKCQ OPN1MW RBP3 RDH11 RDH12 GNAT1 NAPEPLD LRAT GUCA1B GUCA1A GUCA1C HSPG2 APOA2 APOA1 HSD17B1 CYP4V2 APOA4 RBP4 PPEF1 RBP2 FNTB RBP1 STRA6 RLBP1 SLC24A1 PDE6G CNGA1 RHO RCVRN SAG ABCA4 METAP1 PDE6B OPN1MW2 METAP2 PDE6A NMT1 CNGB1 TTR GNB1 RETSAT BCO2 BCO1 MYO7A NMT2 GNGT1 APOC3 APOC2 RPE65 GUCY2D AKR1B10 PNLIP GPIHBP1 GUCY2F LRP1 LPL HSD17B6 GPC1 GPC3 SDR9C7 GPC2 GPC5 LRP2 GPC4 RGS9BP GPC6 LDLR CAMKMT LRP8 AWAT2 AKR1C1 GRK1 AKR1C3 GRK7 LRP10 LRP12 CLPS AKR1C4 AGRN POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE%REACTOME%R-HSA-174411.3 Polymerase switching on the C-strand of the telomere POLD3 RFC1 POLD4 POLD1 POLA1 POLD2 RFC5 POLA2 RFC3 RFC4 RFC2 DSCC1 CHTF18 PRIM2 PRIM1 CHTF8 PCNA ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR%REACTOME%R-HSA-451308.1 Activation of Ca-permeable Kainate Receptor DLG1 DLG4 GRIK5 DLG3 GRIK3 GRIK4 GRIK1 GRIK2 NCALD NEF-MEDIATES DOWN MODULATION OF CELL SURFACE RECEPTORS BY RECRUITING THEM TO CLATHRIN ADAPTERS%REACTOME DATABASE ID RELEASE 72%164938 Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters CD4 CD28 CD8B AP1G1 PACS1 ATP6V1H AP1S2 AP1B1 AP1S1 AP1S3 ARF1 HLA-A B2M AP2A1 AP1M2 AP2B1 AP1M1 AP2A2 AP2S1 AP2M1 LCK CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII CAMKK CAMKIV CASCASDE%REACTOME%R-HSA-442729.2 CREB1 phosphorylation through the activation of CaMKII CaMKK CaMKIV cascasde CREB1 KPNA2 CAMK4 CAMKK1 CAMKK2 CAMK2G CAMK2B FBXL7 DOWN-REGULATES AURKA DURING MITOTIC ENTRY AND IN EARLY MITOSIS%REACTOME%R-HSA-8854050.2 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis PSMD3 CUL1 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 UBA52 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 AURKA PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 UBB PSMB3 UBC PSMB1 PSMF1 RPS27A SHFM1 PSMB8 PSMB9 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 FBXL7 FBXL18 SKP1 PSMD8 PSMD9 PSMD6 RBX1 PSMD7 PSMD4 PSMD5 PSMD2 RSK ACTIVATION%REACTOME%R-HSA-444257.3 RSK activation PDPK1 RPS6KA2 RPS6KA1 MAPK1 MAPK3 RPS6KA3 RPS6KA6 DISEASES OF DNA REPAIR%REACTOME DATABASE ID RELEASE 72%9675135 Diseases of DNA repair MLH1 MSH2 PMS2 NTHL1 MSH6 OGG1 NEIL3 MSH3 NEIL1 RETINOID METABOLISM DISEASE EVENTS%REACTOME DATABASE ID RELEASE 72%6809583 Retinoid metabolism disease events RBP4 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY%REACTOME DATABASE ID RELEASE 72%918233 TRAF3-dependent IRF activation pathway IFIH1 EP300 RNF135 TBK1 MAVS SIKE1 IRF7 TRIM25 DDX58 IFNB1 IRF3 TRAF3 IKBKE CREBBP PROTEIN UBIQUITINATION%REACTOME%R-HSA-8852135.2 Protein ubiquitination UBE2H UBE2A UBE2W USP5 PRKDC UBE2S RNF40 UBA52 UBA1 UBE2K UBE2Q2 RNF181 HIST1H2BF HIST1H2BE HIST1H2BH UBE2L3 HIST1H2BG UBE2R2 HIST1H2BB UBE2C HIST1H2BA UBE2E1 RAD18 UBE2D1 HIST1H2BD HIST1H2BC UBB CDC34 UBC BCL10 RNF20 UBE2J2 RPS27A USP9X OTULIN WDR61 UBE2D2 UBE2D3 LEO1 USP7 HLTF RRAGA UBE2N WAC UBE2G1 RNF144A UBE2G2 CDC73 PEX10 PEX12 PEX13 PEX14 UCHL3 PEX2 UBE2V2 VIMP UBE2Z UBE2B UBE2E3 TMEM129 HLA-A HIST1H2BN HIST1H2BM HIST1H2BO HIST1H2BJ UBE2T CTR9 VCP UBA6 RNF152 HIST1H2BI RTF1 SHPRH HIST1H2BL HIST1H2BK DERL1 PAF1 PCNA DEFECTIVE MPDU1 CAUSES MPDU1-CDG (CDG-1F)%REACTOME DATABASE ID RELEASE 72%4687000 Defective MPDU1 causes MPDU1-CDG (CDG-1f) MPDU1 GAMMA-CARBOXYLATION OF PROTEIN PRECURSORS%REACTOME DATABASE ID RELEASE 72%159740 Gamma-carboxylation of protein precursors F7 GAS6 PROC F9 F10 PROS1 PROZ BGLAP F2 GGCX DEFECTIVE SRD5A3 CAUSES SRD5A3-CDG (CDG-1Q) AND KHRZ%REACTOME DATABASE ID RELEASE 72%4755579 Defective SRD5A3 causes SRD5A3-CDG (CDG-1q) and KHRZ SRD5A3 DEFECTIVE DPM2 CAUSES DPM2-CDG (CDG-1U)%REACTOME%R-HSA-4719377.1 Defective DPM2 causes DPM2-CDG (CDG-1u) DPM1 DPM2 DPM3 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP)%REACTOME%R-HSA-2426168.2 Activation of gene expression by SREBF (SREBP) DHCR7 GPAM TBL1X ELOVL6 TM7SF2 MVD NFYA MVK FDFT1 NFYB LSS NFYC SQLE TGS1 ACACB HELZ2 ACACA CYP51A1 TBL1XR1 SMARCD3 NCOA1 SCD NCOA2 FDPS CREBBP NCOA6 IDI1 MTF1 RXRA SREBF2 PPARA CHD9 MED1 HMGCS1 GGPS1 SP1 FASN CARM1 SC5D PMVK CREB PHOSPHORYLATION%REACTOME%R-HSA-199920.1 CREB phosphorylation RPS6KA5 CREB1 RPS6KA2 RPS6KA1 MAPKAPK2 ATF1 RPS6KA3 DEFECTIVE SLC6A5 CAUSES HYPEREKPLEXIA 3 (HKPX3)%REACTOME%R-HSA-5619089.1 Defective SLC6A5 causes hyperekplexia 3 (HKPX3) SLC6A5 MITOTIC PROPHASE%REACTOME%R-HSA-68875.4 Mitotic Prophase RAB1B GORASP1 NUP107 NUP188 BANF1 RAB2A GORASP2 BLZF1 PPP2R1B PPP2R1A NUP62 NDC1 NUP214 SEC13 NUP133 NUP210 NUP93 NUP50 HIST3H3 NUP54 EMD VRK1 LEMD3 POM121 NUP205 AAAS NUP160 PPP2CA PPP2CB NUP85 TPR LMNB1 GOLGA2 NUP88 NUP43 RAE1 RANBP2 NUP155 NUP153 NUP35 NUPL2 NUP37 SETD8 CCNB2 PRKCB PRKCA LPIN1 LPIN2 NEK9 LPIN3 NEK6 NEK7 SMC4 SMC2 HIST1H2AE HIST1H2AD HIST3H2BB SET HIST1H2AC ARPP19 HIST1H2AB NCAPH2 HIST1H2AJ NCAPG2 ENSA HIST2H3A NCAPD3 CTDNEP1 HIST1H2BF HIST1H2BE NUMA1 HIST1H2BH CNEP1R1 HIST1H2BG MASTL HIST2H3D MCPH1 HIST1H2BB PPP2R2D HIST1H2BA PLK1 HIST2H3C HIST1H2BD HIST1H2BC H2AFB1 CCNB1 HIST1H3J HIST1H3A HIST1H3F HIST1H3G CDK1 HIST1H3H HIST1H3I HIST1H3B HIST1H3C HIST1H3D RB1 HIST1H3E H3F3B HIST1H4K HIST1H4L MAPK1 H3F3A H2BFS HIST1H4A HIST1H4B HIST1H4H HIST1H4I HIST1H4J HIST1H4C HIST1H4D HIST1H4E HIST1H4F HIST2H2AA3 HIST2H2AA4 HIST2H2AC H2AFJ LEMD2 H2AFZ H2AFX H2AFV HIST2H2BE USO1 HIST4H4 HIST1H2BN HIST1H2BM HIST1H2BO HIST1H2BJ HIST1H2BI HIST1H2BL HIST1H2BK HIST2H4A RAB1A HIST2H4B CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX%REACTOME%R-HSA-68689.2 CDC6 association with the ORC:origin complex ORC4 ORC6 ORC1 ORC3 ORC2 E2F2 E2F1 E2F3 CDC6 MCM8 ORC5 HDL ASSEMBLY%REACTOME%R-HSA-8963896.1 HDL assembly ABCA1 APOA1 ZDHHC8 PRKACG PRKACA PRKACB A2M GENERATION OF SECOND MESSENGER MOLECULES%REACTOME DATABASE ID RELEASE 72%202433 Generation of second messenger molecules HLA-DQA2 HLA-DQA1 PLCG2 HLA-DRB5 HLA-DRB4 HLA-DPB1 CD3G HLA-DRA WAS HLA-DRB3 HLA-DRB1 PLCG1 PAK1 PAK3 PAK2 CD4 HLA-DPA1 CD101 VASP TRAV19 LAT ITK CD3E CD3D GRAP2 ENAH ZAP70 EVL HLA-DQB2 LCP2 HLA-DQB1 FYB NCK1 LCK TRAFFICKING OF MYRISTOYLATED PROTEINS TO THE CILIUM%REACTOME DATABASE ID RELEASE 72%5624138 Trafficking of myristoylated proteins to the cilium NPHP3 CYS1 NPHP3-ACAD11 RP2 UNC119B ARL3 T(4;14) TRANSLOCATIONS OF FGFR3%REACTOME%R-HSA-2033515.1 t(4;14) translocations of FGFR3 FGFR3 PI5P, PP2A AND IER3 REGULATE PI3K AKT SIGNALING%REACTOME%R-HSA-6811558.2 PI5P, PP2A and IER3 Regulate PI3K AKT Signaling KIT AKT1 PDGFB PPP2R5B VAV1 ESR2 PPP2R5A STRN PIK3AP1 PTPN11 RAC2 RHOG PPP2R5C FGF6 PIK3R2 FGF9 PPP2R1B PPP2R1A FGF20 FGF1 FGF2 FGF23 FGF3 FYN FGF22 FGF10 FGF4 PPP2R5D IL1RL1 HGF PIK3R3 PIP5K1A MET PIP5K1B IL33 PIP5K1C KLB IRS1 IRS2 INSR FGF19 FGFR4 PIP4K2A PIP4K2B PIP4K2C MAPK1 CD86 MAPK3 TRAT1 LCK CD80 PPP2CA PPP2CB CD28 NRG1 NRG2 FRS2 IRAK4 NRG3 FGF16 FGF7 NRG4 PIK3CD FGF18 INS ESR1 PDGFRA EGF GAB1 PIK3R1 EGFR PIK3CA IRAK1 ERBB2 MYD88 BTC EPGN TGFA AREG HBEGF EREG CD19 PIK3CB TRAF6 SRC RAC1 IER3 PPP2R5E PDGFRB DEFECTIVE CHST14 CAUSES EDS, MUSCULOCONTRACTURAL TYPE%REACTOME DATABASE ID RELEASE 72%3595174 Defective CHST14 causes EDS, musculocontractural type NCAN BGN CSPG5 CSPG4 CHST14 DCN BCAN VCAN PI-3K CASCADE:FGFR1%REACTOME%R-HSA-5654689.2 PI-3K cascade:FGFR1 FRS2 PTPN11 GAB1 PIK3R1 FGF6 PIK3CA FGF9 FGF20 FGF1 FGF2 FGF23 FGF3 FGF22 FGF10 FGF4 LYSOSOMAL OLIGOSACCHARIDE CATABOLISM%REACTOME DATABASE ID RELEASE 72%8853383 Lysosomal oligosaccharide catabolism MANBA MAN2B2 MAN2B1 MAN2C1 PROTEIN-PROTEIN INTERACTIONS AT SYNAPSES%REACTOME DATABASE ID RELEASE 72%6794362 Protein-protein interactions at synapses CASK LIN7A LIN7C SHARPIN LIN7B EPB41L1 LRRC4B PPFIA1 STXBP1 SYT2 SYT9 APBA1 PPFIA4 SYT7 STX1A GRIA3 LRFN3 PTPRD GRIA4 LRFN2 PPFIA3 PPFIA2 DLG2 HOMER3 DLG1 LRFN4 DLG4 DLG3 LRFN1 GRM1 GRM5 LRRTM3 EPB41 LRRTM4 LRRTM1 EPB41L5 LRRTM2 GRIN2A EPB41L2 FLOT1 NTRK3 FLOT2 EPB41L3 HOMER1 HOMER2 GRIN2C GRIN2B GRIN2D IL1RAPL2 PPFIBP1 IL1RAPL1 PPFIBP2 SHANK2 SHANK1 PTPRS NLGN3 NLGN1 NLGN2 NRXN1 NRXN3 NRXN2 SLITRK2 PTPRF SLITRK1 SLITRK4 SLITRK3 SLITRK6 SLITRK5 PDLIM5 SIPA1L1 NLGN4Y DLGAP1 DLGAP3 DLGAP2 NLGN4X DLGAP4 DBNL SYT12 SYT10 BEGAIN GRIN1 APBA3 APBA2 RTN3 GRIA1 SYT1 ARACHIDONIC ACID METABOLISM%REACTOME DATABASE ID RELEASE 72%2142753 Arachidonic acid metabolism CYP4A11 GGT1 PTGR1 PTGR2 GPX2 DPEP2 DPEP1 GPX1 DPEP3 GPX4 PTGS2 PTGS1 CYP1A2 CYP1A1 GGT5 EPHX2 CYP2C19 CBR1 FAAH LTA4H HPGDS PTGDS CYP4F2 FAAH2 CYP4F3 MAPKAPK2 CYP4F8 TBXAS1 CYP8B1 ABCC1 PTGIS PTGES PTGES2 ALOXE3 PTGES3 PON3 HPGD PON2 PON1 LTC4S ALOX15B ALOX5AP AWAT1 PLA2G4A ALOX15 CYP4B1 CYP1B1 ALOX12 CYP2J2 CYP2C9 CYP2C8 FAM213B ALOX5 CYP4F22 CYP4A22 AKR1C3 CYP4F11 CYP2U1 ALOX12B MITOCHONDRIAL TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 72%379726 Mitochondrial tRNA aminoacylation TARS2 AARS2 HARS2 FARS2 YARS2 NARS2 RARS2 CARS2 VARS2 MARS2 DARS2 SARS2 KARS QARS PPA2 PARS2 IARS2 WARS2 EARS2 LARS2 GARS NEUROTRANSMITTER RECEPTORS AND POSTSYNAPTIC SIGNAL TRANSMISSION%REACTOME%R-HSA-112314.7 Neurotransmitter receptors and postsynaptic signal transmission GRIA2 CAMK2D PRKAR2B CAMK2A AKAP5 GRIP1 PRKAR2A CACNG8 EPB41L1 TSPAN7 MYO6 CACNG2 CAMK2G CACNG3 GRIA3 CACNG4 GRIA4 RASGRF2 RPS6KA6 PRKCG NSF DLG1 ACTN2 DLG4 GABRG3 PICK1 GABRG2 ADCY4 ADCY3 PRKACG ADCY2 PRKACA ADCY1 PRKACB GRIN2A PRKAA1 ADCY8 ADCY7 PRKAA2 ADCY6 ADCY5 ARHGEF9 GRIN2C GRIN2B GRIN2D GRIN3B GRIN3A PLCB3 GABRB3 GABRB2 GABRB1 PLCB1 PLCB2 GRIK5 GRIK3 GRIK4 GRIK1 GRIK2 KIF17 GABRR3 PRKAB2 GABRR2 PRKAB1 GABRR1 NEFL GIT1 LRRC7 CHRNA1 CHRNB2 CHRND CHRNB4 CAMKK1 CHRNA3 CAMKK2 CHRNB3 CHRNA2 GLRA1 CHRNA5 GLRA2 GLRA3 CHRNG CHRNA4 CHRNE GABRA2 CHRNA6 GABRQ GABRA1 GABBR2 GABBR1 GABRA6 HRAS GABRA5 GABRA4 GABRA3 GRIN1 NRAS CAMK1 PRKX AP2A1 PRKAG1 PRKAG2 SRC CHRNA7 PRKAG3 RAC1 CHRNA9 PRKCB CASK PDPK1 LIN7A LIN7C LIN7B PRKCA KCNJ2 KCNJ4 APBA1 KCNJ12 GNAL DLG2 NBEA DLG3 RASGRF1 CAMK4 NRGN NPTN RPS6KA3 HTR3E HTR3C RPS6KA2 HTR3D RPS6KA1 HTR3A GNAT3 HTR3B KPNA2 CREB1 PPM1E PPM1F NCALD GNG10 MAPK1 MAPK3 GNG12 GNG11 GNG13 KCNJ3 GNB2 NRG1 KCNJ5 KCNJ6 GNB1 KCNJ10 GNB4 KCNJ9 GNB3 KCNJ15 KCNJ16 GLRB GNB5 GNGT1 GNGT2 GNAI3 GNAI1 GNAI2 GNG3 GNG2 GNG5 MDM2 GNG4 GNG7 GNG8 ADCY9 PRKAR1B PRKAR1A GRIA1 CAMK2B RECYCLING OF BILE ACIDS AND SALTS%REACTOME DATABASE ID RELEASE 72%159418 Recycling of bile acids and salts ALB FABP6 SLCO1A2 BAAT RXRA SLC10A1 SLC10A2 STARD5 ABCB11 NR1H4 NCOA1 SLCO1B1 SLCO1B3 SLC27A5 NCOA2 ABCC3 FGFR2C LIGAND BINDING AND ACTIVATION%REACTOME%R-HSA-190375.3 FGFR2c ligand binding and activation FGF6 FGF9 FGF20 FGF16 FGF1 FGF2 FGF18 FGF23 FGF4 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND%REACTOME DATABASE ID RELEASE 72%174437 Removal of the Flap Intermediate from the C-strand RPA1 RPA2 POLD3 POLD4 WRN RPA3 POLD1 POLD2 DNA2 FEN1 PCNA TRANSCRIPTIONAL REGULATION BY VENTX%REACTOME%R-HSA-8853884.2 Transcriptional Regulation by VENTX TNRC6A TNRC6B FZR1 IL6 TCF7L2 TP53 EHMT2 NFKB1 LEF1 CEBPB CSF1R RELA CDKN2A ANAPC15 ANAPC16 MOV10 ANAPC7 AGO3 UBE2C AGO4 AGO1 UBE2E1 UBE2D1 ANAPC10 ANAPC11 CDC23 CTNNB1 CDC26 CCND1 CDC27 VENTX CDC16 ANAPC4 EHMT1 ANAPC5 ANAPC1 ANAPC2 TNRC6C RUNX3 REGULATES P14-ARF%REACTOME%R-HSA-8951936.1 RUNX3 regulates p14-ARF HDAC4 BRD2 TGFB1 EP300 RUNX3 CBFB KRAS CCND1 RUNX1 THREONINE CATABOLISM%REACTOME%R-HSA-8849175.2 Threonine catabolism SDS GCAT HRSP12 SDSL S33 MUTANTS OF BETA-CATENIN AREN'T PHOSPHORYLATED%REACTOME DATABASE ID RELEASE 72%5358747 S33 mutants of beta-catenin aren't phosphorylated CSNK1A1 PPP2CA PPP2CB PPP2R5B PPP2R5A PPP2R5D CTNNB1 GSK3B PPP2R5C PPP2R1B PPP2R1A AMER1 AXIN1 APC PPP2R5E SYNTHESIS OF ACTIVE UBIQUITIN: ROLES OF E1 AND E2 ENZYMES%REACTOME%R-HSA-8866652.2 Synthesis of active ubiquitin: roles of E1 and E2 enzymes UBE2H UBE2A UBE2G1 UBE2W UBE2G2 USP5 UBE2S UBA52 UBA1 UBE2K UCHL3 UBE2Q2 UBE2Z UBE2L3 UBE2R2 UBE2C UBE2B UBE2E1 UBE2D1 UBE2E3 UBB CDC34 UBC RPS27A UBE2T USP9X UBA6 OTULIN UBE2D2 USP7 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX%REACTOME DATABASE ID RELEASE 72%72695 Formation of the ternary complex, and subsequently, the 43S complex RPS4X RPS3A FAU RPS27L RPS26 RPS25 RPS28 EIF1AX RPS27 RPS29 EIF2S2 RPS20 EIF2S1 RPS21 RPS24 EIF2S3 RPS23 EIF3M EIF3K EIF3L EIF3I EIF3J EIF3G EIF3H EIF3E EIF3F EIF3C EIF3D EIF3A RPS4Y2 EIF3B RPS4Y1 RPS27A RPS3 RPS2 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS15 RPS14 RPS17 RPS16 RPS19 RPS15A RPS18 RPS11 RPS10 RPS13 RPS12 MET ACTIVATES RAP1 AND RAC1%REACTOME%R-HSA-8875555.1 MET activates RAP1 and RAC1 RAPGEF1 RAP1B GAB1 DOCK7 HGF MET RAP1A CRKL CRK RAC1 MET ACTIVATES PTK2 SIGNALING%REACTOME%R-HSA-8874081.1 MET activates PTK2 signaling LAMA5 LAMA2 LAMA1 LAMA4 LAMA3 LAMB3 HGF PTK2 LAMB2 MET LAMB1 ITGB1 LAMC3 LAMC2 LAMC1 SRC ITGA3 ITGA2 BLOCKAGE OF PHAGOSOME ACIDIFICATION%REACTOME DATABASE ID RELEASE 72%9636467 Blockage of phagosome acidification ATP6V1H DEFECTIVE ABCD1 CAUSES ADRENOLEUKODYSTROPHY (ALD)%REACTOME%R-HSA-5684045.1 Defective ABCD1 causes adrenoleukodystrophy (ALD) ABCD1 REGULATION OF EXPRESSION OF SLITS AND ROBOS%REACTOME%R-HSA-9010553.1 Regulation of expression of SLITs and ROBOs RPL26 RPL29 RPL10L RPS4X RPL10A RPL28 RPS3A RPL23A FAU RPL41 RPL3L USP33 RPL10 RPL12 ISL1 RPL13A RPL11 RPS3 RPL14 RPL13 NCBP1 NCBP2 RPS2 RPL15 RPL18 RPL17 RPL19 RPL27A RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS15 RPS14 RPS17 RPS16 RPS19 RPL18A RPL36AL RPS18 RPLP1 RPS11 RPS10 RPLP0 RPS13 PSMD8 PSMD9 RPS12 PSMD6 PSMD7 RPLP2 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 RPL7A PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 RPS27L PSME2 PABPC1 UBA52 RPL37A PSMD10 RPS26 TCEB2 PSMB11 TCEB1 PSMD12 RPS25 RPS28 PSMD11 GSPT2 PSMD14 GSPT1 RPS27 UPF3A RPL36A PSMD13 RPS29 PSMA7 RPS20 PSMB10 RPL35A RPS21 PSMA8 RPS24 ROBO2 RPS23 UPF2 PSMB6 SLIT1 ETF1 PSMB7 SLIT2 ROBO1 PSMB4 RPL22L1 PSMB5 PSMB2 COL4A5 UBB PSMB3 UBC PSMB1 PSMF1 RPS4Y2 RPS4Y1 RPS27A LDB1 SHFM1 PSMB8 PSMB9 PSMC5 PSMC6 EIF4A3 PSMC3 CASC3 CUL2 PSMC4 PSMC1 MAGOH PSMC2 EIF4G1 DAG1 RPL26L1 RPL4 RPL39L RBM8A RPL5 RPL30 RPL3 RPL32 RPL31 RPL34 RPL8 RPL9 RPL6 RPL7 UPF3B MAGOHB RPL36 RNPS1 RPL35 ZSWIM8 RPL38 MSI1 RPL37 RPL39 RPS15A HOXA2 RPL21 RPL23 RPL22 LHX3 LHX2 LHX4 RBX1 LHX9 RPL24 RPL27 MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS%REACTOME DATABASE ID RELEASE 72%174490 Membrane binding and targetting of GAG proteins TSG101 MVB12B MVB12A VPS37C VPS37D UBB VPS37A NMT2 VPS37B UBC UBAP1 RPS27A UBA52 VPS28 SUMOYLATION OF DNA REPLICATION PROTEINS%REACTOME DATABASE ID RELEASE 72%4615885 SUMOylation of DNA replication proteins SUMO2 NUP85 TPR NUP88 NUP43 TOP2B RANGAP1 RAE1 RANBP2 NUP107 NUP155 NUP188 PIAS4 PIAS3 NUP153 BIRC5 NUP62 NUP35 NUPL2 TOP2A NDC1 NUP214 CDCA8 SEC13 NUP37 NUP133 AURKB NUP210 AURKA NUP93 NUP50 UBE2I NUP54 TOP1 INCENP POM121 NUP205 AAAS SUMO1 PCNA NUP160 SUMO3 REGULATION OF RUNX2 EXPRESSION AND ACTIVITY%REACTOME DATABASE ID RELEASE 72%8939902 Regulation of RUNX2 expression and activity PSMD3 CUL1 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 CBFB PSMA2 HIVEP3 PSME3 PSME4 PSME1 PSME2 UBA52 MSX2 PSMD10 WWP1 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 TWIST1 PSMB7 PSMB4 PSMB5 PSMB2 UBB PSMB3 UBC PSMB1 PSMF1 STUB1 RPS27A SHFM1 PSMB8 PSMB9 SKP2 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 NR3C1 PSMC2 STAT1 DLX5 DLX6 ESR1 GSK3B PPARGC1A PPARGC1B SMURF1 NKX3-2 BMP2 SKP1 PSMD8 PSMD9 PSMD6 RBX1 ESRRA PSMD7 PSMD4 PSMD5 PSMD2 NEF MEDIATED CD8 DOWN-REGULATION%REACTOME%R-HSA-182218.1 Nef Mediated CD8 Down-regulation CD8B AP2A1 AP2B1 AP2A2 AP2S1 AP2M1 ATP6V1H FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC%REACTOME%R-HSA-389960.2 Formation of tubulin folding intermediates by CCT TriC CCT6B TUBAL3 TUBB6 CCT6A TUBB3 TUBB1 TUBA3E TUBA8 CCT8 TUBA1C CCT7 TUBA1B CCT5 TUBA4B CCT4 TUBA1A TUBA4A CCT3 CCT2 TUBB4B TUBB4A TUBB2B TUBB2A TCP1 ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 72%264642 Acetylcholine Neurotransmitter Release Cycle CPLX1 RIMS1 BZRAP1 SLC18A3 PPFIA1 PPFIA4 STX1A VAMP2 PPFIA3 PPFIA2 CHAT UNC13B SNAP25 RAB3A SYT1 SLC5A7 FRS-MEDIATED FGFR4 SIGNALING%REACTOME DATABASE ID RELEASE 72%5654712 FRS-mediated FGFR4 signaling HRAS FRS2 PTPN11 FRS3 FGF16 KLB FGF18 NRAS FGF19 FGFR4 FGF6 FGF9 SOS1 FGF20 FGF1 FGF2 FGF23 FGF4 PYRIMIDINE BIOSYNTHESIS%REACTOME%R-HSA-500753.2 Pyrimidine biosynthesis CAD DHODH UMPS ELEVATION OF CYTOSOLIC CA2+ LEVELS%REACTOME%R-HSA-139853.3 Elevation of cytosolic Ca2+ levels TRPC7 TRPC6 TRPC3 STIM1 P2RX7 P2RX6 P2RX5 ORAI2 P2RX4 ORAI1 P2RX3 P2RX2 P2RX1 ITPR1 ITPR2 ITPR3 SIGNALING BY MST1%REACTOME DATABASE ID RELEASE 72%8852405 Signaling by MST1 HPN SPINT2 MST1R SPINT1 DEFECTIVE SLC6A19 CAUSES HARTNUP DISORDER (HND)%REACTOME%R-HSA-5619044.1 Defective SLC6A19 causes Hartnup disorder (HND) SLC6A19 INTERLEUKIN-1 PROCESSING%REACTOME%R-HSA-448706.1 Interleukin-1 processing IL1B CASP1 NFKB1 NFKB2 CTSG IL18 RELA IL1A RETROGRADE TRANSPORT AT THE TRANS-GOLGI-NETWORK%REACTOME%R-HSA-6811440.1 Retrograde transport at the Trans-Golgi-Network VAMP4 RAB43 NSF USP6NL SCOC NAPA TGOLN2 TMF1 ARFRP1 RHOBTB3 ARL1 NAPB VPS51 STX16 VPS53 VPS52 VPS54 GCC2 NAPG GCC1 GOLGA1 ARFIP2 M6PR GOLGA4 STX10 SYS1 IGF2R RABEPK VAMP3 NAA30 STX6 NAA35 VTI1A NAA38 COG8 RIC1 COG7 COG6 COG5 COG4 COG3 RAB9B COG2 RAB6B COG1 RGP1 RAB6A PLIN3 RAB9A RAB GEFS EXCHANGE GTP FOR GDP ON RABS%REACTOME%R-HSA-8876198.3 RAB GEFs exchange GTP for GDP on RABs RIN3 GDI1 AKT1 DENND6A RAB1B GDI2 RIN1 RIN2 TRAPPC6A SBF1 TRAPPC6B SBF2 ANKRD27 CCZ1B DENND4B DENND4A HPS1 RAB18 CCZ1 RAB3GAP2 HPS4 TRAPPC8 MON1A RAB3GAP1 MON1B DENND1C DENND1B RAB32 RAB10 DENND1A DENND2D RAB35 DENND2C RAB5A DENND2A RAB38 RAB3IL1 RAB7A ALS2 DENND3 ALS2CL ST5 RAB21 RAB5C RAB3IP RAB12 RAB13 RAB27B RAB39B RAB8B TRAPPC4 RAB27A RAB7B RIC1 RAB14 RAB9B RAB6B RAB39A RGP1 RAB8A RAB6A RAB9A ULK1 TRAPPC10 GAPVD1 RAB31 TRAPPC2L DENND5B RABGEF1 RINL TRAPPC2 YWHAE AKT2 TRAPPC12 AKT3 TRAPPC11 TRAPPC3 CHM DENND5A TRAPPC13 RAB5B TRAPPC5 TRAPPC9 TRAPPC1 RAB3A RAB1A CHML DENND6B FUSION AND UNCOATING OF THE INFLUENZA VIRION%REACTOME%R-HSA-168270.3 Fusion and Uncoating of the Influenza Virion DNA METHYLATION%REACTOME%R-HSA-5334118.1 DNA methylation HIST1H2AE HIST1H2AD HIST3H2BB HIST1H2AC HIST1H2AB HIST1H2AJ HIST2H3A HIST1H2BF HIST1H2BE HIST1H2BH HIST1H2BG HIST2H3D HIST1H2BB HIST1H2BA HIST2H3C HIST1H2BD HIST1H2BC H2AFB1 DNMT1 HIST1H3J HIST1H3A HIST1H3F HIST1H3G HIST1H3H HIST1H3I HIST1H3B HIST1H3C HIST1H3D HIST1H3E H3F3B HIST1H4K HIST1H4L H3F3A H2BFS HIST1H4A HIST1H4B HIST1H4H HIST1H4I HIST1H4J HIST1H4C HIST1H4D HIST1H4E HIST1H4F HIST2H2AA3 HIST2H2AA4 HIST2H2AC DNMT3L H2AFJ DNMT3B H2AFZ DNMT3A H2AFX H2AFV HIST2H2BE HIST4H4 HIST1H2BN HIST1H2BM HIST1H2BO HIST1H2BJ UHRF1 HIST1H2BI HIST1H2BL HIST1H2BK HIST2H4A HIST2H4B ISG15 ANTIVIRAL MECHANISM%REACTOME%R-HSA-1169408.2 ISG15 antiviral mechanism NUP107 NUP188 KPNA1 UBA52 NUP62 NDC1 NUP214 SEC13 NUP133 NUP210 EIF4A2 EIF4A1 EIF4E3 UBE2E1 UBE2L6 NUP93 IFIT1 NUP50 HERC5 UBB TRIM25 NUP54 KPNA7 KPNA4 ARIH1 UBC KPNA5 KPNA2 KPNA3 JAK1 RPS27A DDX58 PPM1B KPNB1 IRF3 POM121 NUP205 USP41 EIF4E2 EIF4A3 AAAS MAPK3 UBA7 NUP160 USP18 NUP85 FLNB TPR EIF4E EIF4G1 STAT1 NUP88 MX2 NUP43 MX1 EIF2AK2 ISG15 RAE1 NEDD4 UBE2N RANBP2 EIF4G3 EIF4G2 NUP155 NUP153 PLCG1 NUP35 NUPL2 NUP37 PIN1 HYPUSINYLATION%REACTOME DATABASE ID RELEASE 72%204626 Hypusinylation EIF5A2 EIF5A DHPS DOHH RESPONSE TO METAL IONS%REACTOME%R-HSA-5660526.4 Response to metal ions MT1M MTF1 MT1X MT4 MT3 MT2A MT1A CSRP1 MT1F MT1G SNCB MT1H MT1B MT1E DEFECTIVE PAPSS2 CAUSES SEMD-PA%REACTOME DATABASE ID RELEASE 72%3560796 Defective PAPSS2 causes SEMD-PA PAPSS2 SIGNALING BY NODAL%REACTOME%R-HSA-1181150.1 Signaling by NODAL ACVR1C SMAD4 FOXO3 LEFTY1 TDGF1 LEFTY2 DAND5 NODAL CER1 SMAD2 CFC1 SMAD3 FOXH1 ACVR1B GDF1 FURIN ACVR2B PCSK6 ACVR2A DRAP1 INTERLEUKIN-6 SIGNALING%REACTOME%R-HSA-1059683.2 Interleukin-6 signaling JAK2 IL6ST CBL IL6R STAT1 JAK1 STAT3 IL6 PTPN11 SOCS3 TYK2 PTEN LOSS OF FUNCTION IN CANCER%REACTOME%R-HSA-5674404.1 PTEN Loss of Function in Cancer PTEN EVASION OF OXIDATIVE STRESS INDUCED SENESCENCE DUE TO DEFECTIVE P16INK4A BINDING TO CDK4 AND CDK6%REACTOME DATABASE ID RELEASE 72%9632700 Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 CDK6 CDK4 CDKN2A DEFECTS IN VITAMIN AND COFACTOR METABOLISM%REACTOME DATABASE ID RELEASE 72%3296482 Defects in vitamin and cofactor metabolism GIF PCCA MTRR PCCB HLCS CD320 MMAB ABCD4 AMN TCN2 CUBN MTR ACACA MCCC2 MCCC1 LMBRD1 PC MMAA MMACHC BTD MMADHC MUT INTERLEUKIN-2 FAMILY SIGNALING%REACTOME%R-HSA-451927.5 Interleukin-2 family signaling IL3RA IL2RB IL9R STAT1 INPPL1 PIK3CD INPP5D HAVCR2 SHC1 PTPN6 JAK2 PIK3R1 PIK3R2 PIK3CA SYK SOS1 PTK2B IL21 IL21R LGALS9 IL15RA STAT4 PIK3R3 GRB2 SOS2 STAT5A STAT5B CSF2RB CSF2 CSF2RA IL15 GAB2 IL2 PIK3CB IL2RG JAK1 JAK3 STAT3 IL2RA IL5RA IL3 IL9 IL5 LCK GRB7 EVENTS IN ERBB2 SIGNALING%REACTOME%R-HSA-1306955.3 GRB7 events in ERBB2 signaling NRG1 GRB7 NRG2 ERBB2 EVENTS ASSOCIATED WITH PHAGOCYTOLYTIC ACTIVITY OF PMN CELLS%REACTOME%R-HSA-8941413.1 Events associated with phagocytolytic activity of PMN cells LPO MPO DEFECTIVE B4GALT7 CAUSES EDS, PROGEROID TYPE%REACTOME DATABASE ID RELEASE 72%3560783 Defective B4GALT7 causes EDS, progeroid type SDC4 SDC2 SDC3 GPC1 GPC3 B4GALT7 GPC2 BCAN GPC5 VCAN GPC4 GPC6 NCAN BGN HSPG2 CSPG5 CSPG4 DCN SDC1 AGRN MELANIN BIOSYNTHESIS%REACTOME%R-HSA-5662702.2 Melanin biosynthesis SLC45A2 OCA2 TYR TYRP1 DCT BETAKLOTHO-MEDIATED LIGAND BINDING%REACTOME%R-HSA-1307965.1 betaKlotho-mediated ligand binding FGF19 FGFR4 KLB AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE%REACTOME%R-HSA-352230.3 Amino acid transport across the plasma membrane SLC7A7 SLC7A8 SLC7A9 SLC38A2 SLC43A2 SLC3A2 SLC43A1 SLC3A1 SLC7A1 SLC7A3 SLC25A29 SLC6A19 SLC7A5 SLC6A18 SLC6A15 SLC36A4 SLC6A14 SLC1A4 SLC1A5 SLC38A3 SLC6A20 SLC38A5 SLC38A4 SLC6A12 SLC16A10 SLC38A1 SLC6A6 SLC7A11 SLC7A10 SLC36A1 SLC36A2 SLC7A6 VLDL CLEARANCE%REACTOME%R-HSA-8964046.1 VLDL clearance VLDLR APOB APOC4 LSR APOBR APOC1 DEGRADATION OF DVL%REACTOME%R-HSA-4641258.2 Degradation of DVL PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 UBA52 PSMD10 PSMB11 DVL1 PSMD12 DVL3 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 DVL2 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 UBB PSMB3 HECW1 UBC PSMB1 PSMF1 RPS27A SHFM1 PSMB8 PSMB9 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 KLHL12 DACT1 CUL3 PSMD8 PSMD9 PSMD6 RBX1 PSMD7 PSMD4 PSMD5 PSMD2 MET PROMOTES CELL MOTILITY%REACTOME%R-HSA-8875878.1 MET promotes cell motility RAPGEF1 LAMA5 LAMA2 LAMA1 LAMA4 LAMA3 LAMB3 LAMB2 LAMB1 CRK GAB1 RAP1B HGF PTK2 MET CRKL RAP1A ITGB1 LAMC3 DOCK7 LAMC2 LAMC1 TNS4 SRC TNS3 RAC1 ITGA3 ITGA2 EGFR DOWNREGULATION%REACTOME%R-HSA-182971.6 EGFR downregulation SH3GL1 EPS15L1 PTPN12 EPN1 SPRY2 SPRY1 ARHGEF7 PTPN3 STAM EGF CBL EGFR UBA52 HGS CDC42 SH3GL3 STAM2 SH3GL2 BTC EPGN TGFA AREG UBB HBEGF EREG UBC RPS27A SH3KBP1 PTPRK EPS15 EPH-EPHRIN SIGNALING%REACTOME%R-HSA-2682334.1 EPH-Ephrin signaling NCSTN EPHA5 ADAM10 SDC2 EPHA4 APH1B EPHA7 CFL1 EPHA6 DNM1 VAV2 EPHA8 ARHGEF7 LIMK2 LIMK1 ARPC1B EPHA3 ARPC1A EPHA1 EPHA2 ROCK1 EPHA10 ROCK2 ACTG1 ACTB PSENEN CDC42 TIAM1 PAK1 ARPC4 ARPC5 ARHGEF28 FYN ARPC2 EFNA5 ARPC3 EFNA4 PAK3 EFNA1 ACTR3 PAK2 EFNA3 ACTR2 EFNA2 EFNB2 EFNB1 EFNB3 EPHB2 EPHB1 GRIN2B PTK2 EPHB4 EPHB3 MYH14 MYH10 MMP2 LYN MYL12A MYL12B YES1 GIT1 MYH11 WASL MYL6 MYL9 HRAS RASA1 MYH9 SDCBP ITSN1 GRIN1 RHOA CLTC CLTB CLTA AP2A1 AP2B1 AP2A2 CLTCL1 AP2S1 NGEF AP2M1 NCK2 PSEN2 MMP9 PSEN1 RAC1 KALRN VAV3 APH1A CYP2E1 REACTIONS%REACTOME DATABASE ID RELEASE 72%211999 CYP2E1 reactions CYP2C19 CYP2A7 CYP2C9 CYP2A13 CYP2A6 CYP2C8 CYP2F1 CYP2B6 CYP2D6 CYP2E1 CYP2S1 PI-3K CASCADE:FGFR3%REACTOME%R-HSA-5654710.2 PI-3K cascade:FGFR3 FRS2 PTPN11 FGF16 FGF18 GAB1 PIK3R1 PIK3CA FGF9 FGF20 FGF1 FGF2 FGF23 FGF4 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA%REACTOME DATABASE ID RELEASE 72%159230 Transport of the SLBP Dependant Mature mRNA NUP85 TPR EIF4E NUP88 NUP43 RAE1 RANBP2 NUP107 NUP155 NUP188 NUP153 SLBP NUP62 NUP35 NUPL2 NXF1 NDC1 NUP214 SEC13 NUP37 NUP133 NUP210 NUP93 NUP50 NUP54 POM121 NUP205 NCBP1 NCBP2 AAAS NUP160 RAF ACTIVATION%REACTOME%R-HSA-5673000.2 RAF activation PPP2CA CAMK2D PPP2CB CAMK2A MAP2K1 PPP2R5B MAP2K2 PPP2R5A BRAF RAF1 CAMK2G ARAF PPP2R5C JAK2 KSR1 PPP2R1B PPP2R1A PHB MARK3 HRAS PPP2R5D NRAS YWHAB BRAP SRC CAMK2B PPP2R5E MAP3K11 SIGNALING BY FGFR4 IN DISEASE%REACTOME%R-HSA-5655291.1 Signaling by FGFR4 in disease GAB1 PIK3R1 FGFR4 HRAS PIK3CA PLCG1 FRS2 SOS1 NRAS TRIGLYCERIDE CATABOLISM%REACTOME DATABASE ID RELEASE 72%163560 Triglyceride catabolism FABP1 FABP2 PNPLA4 FABP3 PNPLA5 FABP4 PLIN3 CAV1 FABP5 PPP1CC PLIN1 LIPE FABP6 FABP7 GPD2 MGLL ABHD5 FABP12 PPP1CB PRKACG PRKACA PRKACB PPP1CA FABP9 RRNA MODIFICATION IN THE NUCLEUS AND CYTOSOL%REACTOME DATABASE ID RELEASE 72%6790901 rRNA modification in the nucleus and cytosol WBSCR22 MPHOSPH10 NOL11 NAT10 UTP14A UTP14C HEATR1 NOL6 DKC1 NHP2 FBL GAR1 DIMT1 UTP11L NOP10 EMG1 UTP20 RCL1 RRP9 DDX49 DDX47 WDR75 UTP15 DDX52 UTP18 RRP7A PNO1 BMS1 TBL3 WDR46 WDR43 WDR36 RPS2 DIEXF TSR3 NOC4L RRP36 UTP6 UTP3 NOP2 RPS9 RPS7 NHP2L1 NOP14 WDR3 RPS6 RPS14 DCAF13 NOP58 KRR1 FCF1 NOP56 THUMPD1 PWP2 TRMT112 IMP3 IMP4 CIRH1A PDCD11 DHX37 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 27-HYDROXYCHOLESTEROL%REACTOME DATABASE ID RELEASE 72%193807 Synthesis of bile acids and bile salts via 27-hydroxycholesterol PTGIS AKR1D1 RXRA CYP7B1 HSD3B7 AKR1C1 AKR1C3 AKR1C2 NR1H4 CYP7A1 NCOA1 AKR1C4 CYP8B1 NCOA2 CYP27A1 ACYL CHAIN REMODELLING OF PC%REACTOME%R-HSA-1482788.3 Acyl chain remodelling of PC MBOAT2 TMEM86B LPCAT4 LPCAT3 LPCAT2 LPCAT1 PLB1 PLA2G12A PLA2G4F PLA2G4D PLA2G4B PLA2G4C PLA2G4A PLA2G16 PLA2G10 PLA2G1B PLBD1 PLA2R1 PLA2G3 PLA2G2F PLA2G5 PLA2G2D PLA2G2E PLA2G6 PNPLA8 PLA2G2A FCGR3A-MEDIATED PHAGOCYTOSIS%REACTOME%R-HSA-9664422.1 FCGR3A-mediated phagocytosis VAV1 WIPF1 VAV2 WIPF2 FGR WIPF3 ELMO1 ELMO2 CRK DOCK1 ARPC1B ARPC1A WAS MYO9B ACTG1 ACTB NCKIPSD CDC42 ARPC4 NCKAP1L ARPC5 FYN ARPC2 IGHG4 WASF1 ARPC3 WASF2 IGHG1 ACTR3 IGHG2 ACTR2 WASF3 IGKV1-12 MYH2 MYO10 MYO1C BAIAP2 PTK2 ABI2 ABI1 IGKV2D-28 IGKV4-1 IGKV2D-30 MAPK1 MAPK3 IGKV3-11 LYN YES1 MYO5A WASL CD3G FCGR3A IGKV2-28 SYK IGKV3D-20 HCK ABL1 MYH9 CYFIP2 CYFIP1 NCKAP1 BRK1 BTK IGKV5-2 RAC1 NCK1 VAV3 ENDOSOMAL VACUOLAR PATHWAY%REACTOME DATABASE ID RELEASE 72%1236977 Endosomal Vacuolar pathway HLA-A HLA-G B2M HLA-E LNPEP HLA-B CTSV HLA-C CTSS CTSL HLA-F STIMULATION OF THE CELL DEATH RESPONSE BY PAK-2P34%REACTOME DATABASE ID RELEASE 72%211736 Stimulation of the cell death response by PAK-2p34 PAK2 CASP3 INHIBITION OF INTERFERON SYNTHESIS%REACTOME DATABASE ID RELEASE 72%168305 Inhibition of Interferon Synthesis ACROSOME REACTION AND SPERM:OOCYTE MEMBRANE BINDING%REACTOME%R-HSA-1300645.2 Acrosome Reaction and Sperm:Oocyte Membrane Binding IZUMO1 ACR CD9 IZUMO3 IZUMO2 IZUMO4 SCAVENGING BY CLASS H RECEPTORS%REACTOME%R-HSA-3000497.1 Scavenging by Class H Receptors STAB2 STAB1 APOB SPARC AMER1 MUTANTS DESTABILIZE THE DESTRUCTION COMPLEX%REACTOME%R-HSA-4839748.1 AMER1 mutants destabilize the destruction complex CSNK1A1 PPP2CA PPP2CB PPP2R5B PPP2R5A PPP2R5D GSK3B PPP2R5C PPP2R1B PPP2R1A AMER1 AXIN1 APC PPP2R5E RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF KERATINOCYTES%REACTOME%R-HSA-8939242.1 RUNX1 regulates transcription of genes involved in differentiation of keratinocytes CTSK SOCS4 SERPINB13 SOCS3 CTSV CBFB CTSL RUNX1 DEFECTIVE CYP2U1 CAUSES SPASTIC PARAPLEGIA 56, AUTOSOMAL RECESSIVE (SPG56)%REACTOME DATABASE ID RELEASE 72%5579011 Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56) CYP2U1 G-PROTEIN MEDIATED EVENTS%REACTOME%R-HSA-112040.1 G-protein mediated events CAMK2D CAMK2A PRKAR2B PRKAR2A PRKCD PRKCA CAMK2G PRKCG GNAL ITPR1 NBEA ITPR2 ITPR3 CAMK4 ADCY4 ADCY3 PRKACG ADCY2 PRKACA ADCY1 PRKACB ADCY8 ADCY7 ADCY6 ADCY5 PDE1C ADRBK1 GNAT2 GNAT3 GNAT1 PLCB3 PLCB4 PLCB1 PLCB2 KPNA2 CREB1 GNAZ MAPK1 GNAO1 CAMKK1 CAMKK2 PDE1B PDE1A PLA2G4A GNAI3 GNAI1 GNAI2 AHCYL1 PRKX ADCY9 PRKAR1B PRKAR1A CAMK2B SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX)%REACTOME DATABASE ID RELEASE 72%2142691 Synthesis of Leukotrienes (LT) and Eoxins (EX) ABCC1 CYP4A11 ALOX15 CYP4B1 GGT1 PTGR1 LTA4H DPEP2 DPEP1 DPEP3 ALOX5 CYP4F22 CYP4F2 CYP4F3 LTC4S CYP4F8 MAPKAPK2 CYP4A22 CYP4F11 GGT5 ALOX5AP REGULATION OF MITOTIC CELL CYCLE%REACTOME DATABASE ID RELEASE 72%453276 Regulation of mitotic cell cycle PSMD3 CUL1 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 BUB1B CCNA2 CCNA1 UBA52 CDC20 PSMD10 PTTG1 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 ANAPC15 AURKB ANAPC16 AURKA PSMB6 ANAPC7 PSMB7 UBE2C PLK1 UBE2E1 PSMB4 UBE2D1 ANAPC10 PSMB5 ANAPC11 PSMB2 CCNB1 UBB CDC23 PSMB3 CDC26 CDC27 UBC CDC16 PSMB1 CDK1 ANAPC4 PSMF1 ANAPC5 ANAPC1 RPS27A CDC14A ANAPC2 SHFM1 PSMB8 FBXO5 PSMB9 SKP2 PSMC5 PSMC6 PSMC3 PSMC4 BUB3 PSMC1 PSMC2 FZR1 MAD2L1 NEK2 CDK2 BTRC SKP1 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 COMPETING ENDOGENOUS RNAS (CERNAS) REGULATE PTEN TRANSLATION%REACTOME DATABASE ID RELEASE 72%8948700 Competing endogenous RNAs (ceRNAs) regulate PTEN translation TNRC6A TNRC6B MOV10 AGO3 TNRC6C AGO4 AGO1 AGO2 DEUBIQUITINATION%REACTOME%R-HSA-5688426.3 Deubiquitination CYLD RAD23B OTUD7B TNFAIP3 CCNA2 CCNA1 CDC20 ARRB1 FOXO4 BIRC2 BIRC3 TAF10 USP21 ADRB2 TRAF3 CCP110 SMAD7 UCHL1 SENP8 UCHL3 UCHL5 TOMM20 USP15 FOXK2 FOXK1 MBD5 MBD6 ADRM1 ASXL1 ASXL2 VDAC3 VDAC2 USP30 BECN1 TOMM70A NFRKB ACTB BRCC3 HGS HIST1H2AE HIST1H2AD NLRP3 HIST3H2BB HIST1H2AC HIST1H2AB NFKBIA IKBKG HIST1H2AJ INO80 HIST1H2BF HIST1H2BE AR HIST1H2BH HIST1H2BG HIST1H2BB BAP1 HIST1H2BA WDR48 UBE2D1 HIST1H2BD HIST1H2BC BABAM1 UIMC1 CDK1 ACTL6A SUDS3 MYC SKP2 CDC25A VDAC1 MCRS1 HIST2H2AA3 YY1 HIST2H2AA4 USP34 RUVBL1 HIST2H2AC AXIN2 OTUD5 INO80C INO80B INO80E USP11 IFIH1 INO80D TGFB1 RNF135 SMAD4 HIST2H2BE MAVS TRRAP KAT2B CLSPN KAT2A TGFBR1 RHOA TGFBR2 HCFC1 HIST1H2BN HIST1H2BM CFTR HIST1H2BO HIST1H2BJ FAM175A HIST1H2BI ATXN3 HIST1H2BL UFD1L HIST1H2BK POLB TADA2B ACTR5 RAD23A ACTR8 HIST2H2AB USP10 TFPT HIST2H2BF JOSD2 JOSD1 PTRH2 USP33 HIST3H2A BRE IL33 KDM1B ATXN3L USP13 MUL1 TNKS TNKS2 HIST1H2AG RNF146 HIST1H2AA HIST1H2AM OTUD3 USP9X HIST1H2AL HIST1H2AI HIST1H2AH HIST1H2AK SNX3 RCE1 OTUD7A IDE NEDD8 RIPK2 ATXN7 TP53 ESR1 NOD1 NOD2 STAMBPL1 TADA3 VCPIP1 BARD1 FAM175B OGT MYSM1 TNIP2 OTUB1 OTUB2 TNIP1 TNIP3 RHOT1 USP17L4 USP17L5 USP17L8 RNF128 USP22 PSMD8 PSMD9 PSMD6 GATA3 BRCA1 WDR20 PSMD7 PSMD4 PSMD5 AXIN1 PSMD2 PSMD3 USP17L2 USP17L3 PSMD1 USP17L1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 DDB2 STAM PSMA2 PSME3 ARRB2 PSME4 USP5 PSME1 PSME2 USP3 SMAD2 UBA52 SMAD3 PSMD10 FKBP8 PSMB11 PSMD12 TAF9B STAMBP STAM2 PSMD11 PSMD14 PSMD13 APC PSMA7 PSMB10 PSMA8 KEAP1 PSMB6 EP300 PSMB7 SMURF2 PSMB4 PSMB5 PSMB2 UBB TRIM25 PSMB3 RNF123 UBC PSMB1 PSMF1 RPS27A DDX58 SIAH2 SHFM1 USP17L30 PSMB8 YOD1 PSMB9 PSMC5 PSMC6 PSMC3 USP7 PSMC4 PSMC1 USP2 USP18 PSMC2 ZRANB1 MAT2B HIF1A USP17L27 USP17L26 USP17L29 USP17L28 RIPK1 USP17L21 USP17L20 TRAF2 USP17L22 USP17L25 USP17L24 USP17L15 USP17L18 USP17L17 USP17L19 USP17L10 USP17L12 USP17L11 USP17L13 PARK2 SMAD1 MDM2 USP37 USP47 USP4 USP48 USP49 MDM4 USP42 USP44 USP14 USP16 USP12 VCP USP19 TRAF6 USP24 USP25 PTEN USP26 TAB1 USP20 MAP3K7 USP8 USP28 DEFECTIVE LARGE CAUSES MDDGA6 AND MDDGB6%REACTOME DATABASE ID RELEASE 72%5083627 Defective LARGE causes MDDGA6 and MDDGB6 B4GAT1 LARGE TRISTETRAPROLIN (TTP, ZFP36) BINDS AND DESTABILIZES MRNA%REACTOME%R-HSA-450513.2 Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA DCP1A EXOSC7 TNPO1 DIS3 EXOSC6 EXOSC5 EXOSC4 XRN1 EXOSC9 EXOSC8 EXOSC3 YWHAB MAPKAPK2 EXOSC2 DCP2 EXOSC1 GSD II%REACTOME%R-HSA-5357609.3 GSD II GAA GYG1 DECTIN-2 FAMILY%REACTOME%R-HSA-5621480.3 Dectin-2 family LYN PLCG2 CLEC4A CLEC4E MUC12 CLEC6A MUC20 MUC13 MUC15 MUCL1 SYK MUC3A MUC5AC FYN MUC1 MUC7 MUC4 MUC6 CLEC4C MUC17 CLEC4D MUC5B MUC21 FCER1G CLEC10A METABOLISM OF LIPIDS%REACTOME DATABASE ID RELEASE 72%556833 Metabolism of lipids GPX2 LSS THRAP3 VAC14 LPGAT1 PITPNB CPNE7 CPNE6 LCLAT1 PLB1 LIPI LIPH CPNE1 CPNE3 TMEM55B FAM120B MFSD2A DGAT2 PCYT2 PRKAA2 CSNK2A1 DGAT1 STARD7 CSNK2A2 HRASLS2 PISD PLA2G15 GNPAT LIPE PLA2G16 PHOSPHO1 GPD2 NSDHL PLA2G10 GPD1 CYP2D6 CSNK2B PLBD1 HRASLS5 STARD3 PLA2R1 STARD4 PLA1A STARD5 TXNRD1 CDS1 STARD6 ABHD4 ABHD3 CHAT PLA2G3 RUFY1 PLD4 PLD6 PLA2G5 CARM1 PLD1 PLA2G6 PLD3 PLD2 PGS1 CYP2E1 PTDSS2 PTDSS1 PTPMT1 OSBPL8 TMEM86B MTMR1 CHKB MTMR2 OSBPL5 HACD1 CHKA MTMR3 RARRES3 STARD10 EPT1 DGAT2L6 CRLS1 ABCB4 PEMT MTMR8 ALPI MTMR9 CDS2 SLC44A5 MTMR4 ACHE HACD3 SLC44A3 HACD2 SLC44A4 SLC44A1 MTMR6 SLC44A2 LPCAT1 MTMR7 PCTP HACD4 TAZ OSBPL10 ACP6 HSD11B1 FAM73A HSD11B2 FAM73B UGT8 PLA2G12A PLA2G4F PCYT1B PCYT1A PPARGC1A PLA2G4D HAO2 PLA2G4B PPARGC1B PLA2G4C PLA2G4A ABCA1 GPCPD1 HADHB B3GALNT1 HADHA PITPNM1 PITPNM3 PITPNM2 CYP2C9 MGLL AGPAT5 CYP2C8 AGPAT6 AGPAT9 PLA2G1B AGPAT1 ARF3 AGPAT2 ARF1 AGPAT3 AGPAT4 HEXB AWAT2 GPAT2 HEXA CEPT1 CDIPT PLA2G2F AACS BCHE PLA2G2D PLA2G2E AGK PNPLA8 ELOVL1 MBOAT7 PLA2G2A DDHD2 ELOVL4 MBOAT1 ELOVL5 MBOAT2 DDHD1 ELOVL2 ETNPPL ELOVL3 GPAM ELOVL6 LPCAT4 ELOVL7 ETNK2 PTGR1 LPCAT3 PTGR2 ETNK1 SUMF2 LPCAT2 SUMF1 PNPLA3 BDH2 CHPT1 BDH1 GPD1L LPIN1 LPIN2 LPIN3 PNPLA2 PTGS2 PTGS1 GC GK FABP9 FABP1 FABP2 FABP3 FABP4 FABP5 ACADVL ECHS1 ACAA2 FABP6 ACSM3 FABP7 ECI1 ACSM6 DBI MCEE PECR RORA ACADL THEM5 THEM4 HPGDS ACADM OSBP ACAD11 HADH ACADS ACAD10 DECR1 ACBD7 KPNB1 ACBD6 ACOT9 CYP19A1 MECR ACAT2 ACOT7 ACAT1 MMAA SLCO1B1 ACOT11 SLCO1B3 ACOT12 PMVK ACOT13 HACL1 MUT MCAT SRD5A2 SRD5A1 ACSF2 SRD5A3 PCCA PCCB NDUFAB1 ACOT2 ACOT1 SLCO1A2 FHL2 PIK3CD PIK3CG ME1 PIK3R1 ARNT PIK3CA SLC25A17 PIK3C3 HDAC3 SEC23A GBA PPM1L HSD17B14 HSD17B13 LRP2 HSD17B12 HSD17B11 SLC25A20 SEC24B SEC24A SCP2 SLC25A1 SEC24D SEC24C CCNC ARSA CH25H PRKACG FAR1 PRKACA FAR2 PRKACB CLOCK SAR1B AGMO PEX11A PIK3R4 PIP5K1A PIK3R3 PIP5K1B LTA4H PIP5K1C PIK3R6 PIK3R5 GSTM4 ARSJ CYP4F2 CYP4F3 ARSK CYP4F8 ARSH ARSI ARSF ARSG FASN ARSD LGMN HMGCLL1 MTMR10 ARSE MTMR12 ARSB MTMR14 CTSA MED19 MED16 ACER2 MED15 ACER1 MED18 MED17 MED12 ACER3 SMPD3 RGL1 MED11 MOGAT3 SMPD2 MOGAT2 MED14 MOGAT1 MED13 TECR AKR1B1 SMPD4 MED10 SMPD1 ARV1 TSPO SPTLC1 SPTLC2 SPTLC3 SPHK2 MED27 MED26 CD36 MED29 MED28 NCOA1 MED23 MED22 NCOA2 MED25 STARD3NL MED24 NCOA6 CYP21A2 NCOA3 MED21 MED20 AGPS AKR1D1 ACSBG1 RXRB PPARG RXRA PPARA ACSBG2 PPARD PLEKHA1 SAMD8 PIK3CB AKR1C1 PLEKHA5 AKR1C3 PLEKHA6 ABCB11 AKR1C2 PLEKHA3 PLEKHA4 AKR1C4 PLEKHA8 PPP1CA CRAT GLB1L SUMO2 ESYT3 SPHK1 ESYT2 SLC27A1 ESYT1 CYP46A1 FADS2 GGT1 SBF1 ACAA1 NUDT19 SBF2 TRIB3 DPEP2 DPEP1 FADS1 DPEP3 PIAS4 ACACB ACACA PIK3R2 EBP CYP11A1 ACLY SLC27A3 SLC27A2 SLC27A5 GGT5 FDPS NRF1 VDR CYP2C19 EP300 CAV1 NPAS2 CYP11B2 MED30 CYP11B1 MED31 CHD9 KDSR CPT2 MAPKAPK2 BMX SP1 TBXAS1 OSBPL1A CYP27B1 CPTP ALAS1 CYP24A1 CYP2R1 MVD MVK CERS3 CERS4 CERS5 HMGCL CERS6 MBTPS1 GLB1 THRSP RAN MBTPS2 TNFRSF21 CERS1 CERS2 AWAT1 MID1IP1 CYP4B1 FDXR CYP1B1 CERK SULT2A1 CUBN MED1 ACOT8 STS MED8 MED9 MED4 MED6 MED7 CYP39A1 FDX1 ACOT6 NEU2 ACOT4 NEU3 NEU1 B4GALNT1 DECR2 SLC10A1 CDK19 SLC10A2 MED13L FA2H CYP1A2 CYP1A1 SERPINA6 CROT BAAT SREBF2 HSD17B3 FITM1 HSD17B4 FITM2 HSD17B7 ASAH1 HSD17B8 ASAH2 CYP17A1 HSD17B1 ORMDL2 GPS2 HSD17B2 ORMDL3 PNPLA7 ORMDL1 SC5D CYP8B1 NUDT7 PNPLA4 PNPLA5 PNPLA6 INPPL1 MSMO1 AGT FIG4 ENPP6 ENPP7 TPTE2 AHR FABP12 PPP1CB DHRS7B MORC2 UBE2I ABHD5 DEGS1 CYP4F22 DEGS2 TNFAIP8 PSAP CYP4A22 ACOXL ESRRA DHCR24 TECRL CYP4F11 CDK8 ALB CYP4A11 DHCR7 ACOX2 ACOX3 GM2A GK2 GPX1 GPX4 OXCT1 TGS1 OXCT2 HSD3B7 HSD3B2 HSD3B1 RAB5A ACSS3 SMARCD3 GALC GLA PI4K2B PTPN13 GLTP FAAH PRKD3 PRKD2 GDE1 PRKD1 PI4K2A PTGDS ACSL1 SACM1L ACSL6 ACSL5 ACSL4 ACSL3 INPP4A CYP27A1 INPP4B PTGES CGA FDFT1 NR1D1 SGPL1 SQLE INPP5F INPP5D INPP5E PPT1 INPP5J PPT2 INPP5K SCAP SIN3A CIDEA ALOX15B CIDEC NCOR2 NCOR1 STAR MTF1 AKR1B15 PLIN3 HILPDA AHRR PLIN2 PLIN1 ANGPTL4 GLIPR1 SGMS2 TNFAIP8L1 ANKRD1 FAM213B TNFAIP8L3 ALOX5 TNFAIP8L2 NR1H2 NR1H4 G0S2 NR1H3 FDX1L ALOX12B ARNTL TBL1X TM7SF2 PPP1CC OLAH ARNT2 SCD5 CSNK1G2 OCRL INSIG2 INSIG1 TBL1XR1 MTM1 OSBPL9 RAB4A ALDH3B2 OSBPL7 ALDH3B1 OSBPL6 ACBD5 OSBPL3 ACBD4 OSBPL2 EPHX2 SYNJ2 SYNJ1 ACSF3 PIK3C2G PIK3C2A PIK3C2B HMGCS2 LBR HMGCS1 GGPS1 FAAH2 APOA2 APOA1 APOA5 PIP4K2A PPAP2B PIP4K2B PPAP2A ABCD1 PIP4K2C PPAP2C PRKAB2 TPTE ABCC3 ABCC1 CYP3A4 PTGIS EHHADH UGT1A9 ALOXE3 PON3 HPGD PON2 CYP51A1 PON1 LTC4S RAB14 VAPA VAPB SGPP2 SGPP1 POMC PIKFYVE SCD ALOX5AP CREBBP GBA2 PRKAG2 CPT1A CPT1B TIAM2 CYP2U1 SLC22A5 BZRAP1 LHB HELZ2 UGCG CBR1 CYP7B1 GDPD1 GDPD3 GDPD5 CYP7A1 SPTSSB SPTSSA CBR4 NFYA PTGES2 NFYB NFYC PTGES3 GRHL1 PHYH PPAPDC2 IDI1 IDI2 ALOX15 ALOX12 CYP2J2 AMACR PI4KB PTEN DISEASES ASSOCIATED WITH GLYCOSAMINOGLYCAN METABOLISM%REACTOME DATABASE ID RELEASE 72%3560782 Diseases associated with glycosaminoglycan metabolism SDC4 SDC2 SDC3 B3GALT6 ST3GAL3 B4GALT7 KERA FMOD EXT1 PRELP CHST6 EXT2 SLC26A2 B3GAT3 CHSY1 SDC1 LUM GPC1 B4GALT1 PAPSS2 GPC3 GPC2 GPC5 BCAN GPC4 VCAN GPC6 NCAN CHST3 HEXB BGN HSPG2 HEXA CSPG5 CSPG4 CHST14 DCN OMD OGN AGRN TRANSLESION SYNTHESIS BY Y FAMILY DNA POLYMERASES BYPASSES LESIONS ON DNA TEMPLATE%REACTOME DATABASE ID RELEASE 72%110313 Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template POLK RPA1 POLE RPA2 POLD3 POLH POLD4 RFC1 MAD2L2 USP43 RPA3 POLD1 POLD2 ISG15 RFC5 REV1 RFC3 RFC4 RFC2 USP10 RCHY1 UBA52 NPLOC4 POLE4 SPRTN KIAA0101 UBE2L6 POLE2 UBB TRIM25 POLE3 REV3L UBC RPS27A VCP UFD1L POLI PCNA UBA7 DIGESTION OF DIETARY CARBOHYDRATE%REACTOME%R-HSA-189085.2 Digestion of dietary carbohydrate CHIA CHIT1 AMY2A AMY1A AMY2B AMY1B TREH AMY1C MGAM SI LCT FGFR4 LIGAND BINDING AND ACTIVATION%REACTOME%R-HSA-190322.1 FGFR4 ligand binding and activation FGF19 FGFR4 FGF6 FGF9 FGF20 FGF16 FGF1 FGF2 KLB FGF18 FGF23 FGF4 RNA POLYMERASE II TRANSCRIPTION TERMINATION%REACTOME%R-HSA-73856.4 RNA Polymerase II Transcription Termination CPSF4 CPSF7 CPSF1 CSTF3 SLBP CPSF3 CSTF2 CPSF2 CSTF2T WDR33 NUDT21 FIP1L1 PABPN1 CLP1 PCF11 PAPOLA CSTF1 SYMPK LSM10 LSM11 NCBP1 NCBP2 EIF4A3 CASC3 MAGOH ZNF473 THOC1 THOC3 THOC2 THOC5 THOC7 CDC40 THOC6 SRRM1 DDX39A DDX39B ZC3H11A SARNP SRSF2 SRSF3 SRSF4 SRSF5 SRSF6 SRSF7 SLU7 SRSF9 FYTTD1 LUZP4 RBM8A POLDIP3 SRSF1 U2AF1 U2AF1L4 SNRPD3 U2AF2 DHX38 SNRPG SRSF11 CHTOP UPF3B SNRPE MAGOHB RNPS1 SNRPF SNRPB NICOTINATE METABOLISM%REACTOME%R-HSA-196807.3 Nicotinate metabolism PTGIS CARKD NMNAT3 NMNAT2 NUDT12 NADK2 NMNAT1 PTGS2 BST1 APOA1BP CD38 PARP16 NNMT PARP14 PARP10 SLC22A13 NMRK2 NAMPT NMRK1 PARP6 PARP4 PARP9 PARP8 NADSYN1 NADK QPRT RNLS NAPRT SLC5A8 CYP8B1 NT5E PAUSING AND RECOVERY OF HIV ELONGATION%REACTOME DATABASE ID RELEASE 72%167290 Pausing and recovery of HIV elongation GTF2F1 GTF2F2 POLR2A POLR2B TCEB3C POLR2C POLR2D TCEB3B POLR2G POLR2E NELFB POLR2F NELFA NELFCD POLR2H POLR2I POLR2J NELFE POLR2K TCEB3CL2 POLR2L TCEB3 TCEB2 TCEB1 TCEB3CL CDK9 TCEA1 CCNK CCNT2 ELL CCNT1 SSRP1 CTDP1 SUPT16H SUPT4H1 SUPT5H CATECHOLAMINE BIOSYNTHESIS%REACTOME%R-HSA-209905.1 Catecholamine biosynthesis DDC TH PNMT DBH NADE MODULATES DEATH SIGNALLING%REACTOME%R-HSA-205025.1 NADE modulates death signalling CASP2 NGFRAP1 CASP3 YWHAE NGFR NGF FGFR1C AND KLOTHO LIGAND BINDING AND ACTIVATION%REACTOME%R-HSA-190374.2 FGFR1c and Klotho ligand binding and activation FGF23 SMAC(DIABLO)-MEDIATED DISSOCIATION OF IAP:CASPASE COMPLEXES%REACTOME%R-HSA-111464.3 SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes CASP7 CASP3 CASP9 APAF1 DIABLO XIAP CYCS SLC-MEDIATED TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 72%425407 SLC-mediated transmembrane transport SLC25A18 SLC7A7 SLC7A8 SLC7A9 SLC24A2 SLC24A4 SLC24A3 SLC20A2 SLC43A2 SLC20A1 SLC43A1 SLC5A12 SLC3A1 SLC7A1 SLC7A3 SLC25A26 SLC25A29 SLC17A6 SLC17A1 SLC25A22 CTNS SLC8B1 SLC6A7 SLC4A7 SLC4A8 SLC4A9 SLC24A5 SLC6A2 SLC6A5 LCN9 SLC35B4 SLC6A9 LCN15 SLC18A1 LCN12 PDZD11 SLCO2B1 APOD SLC5A6 SLC16A2 SLC35A2 SLC5A8 SLC35A1 SLC35A3 SLC35C1 SLC33A1 SLCO1C1 ARL2BP SLCO4A1 SLCO4C1 SLCO2A1 LCN1 SLC27A6 SLC29A4 AVP SLC28A2 SLC29A1 SLC28A1 SLC29A3 SLC28A3 SLC29A2 SLC27A4 SLC44A5 SLC44A3 SLC44A4 SLC44A1 SLC44A2 SLC5A5 SLC34A3 SLC34A2 SLC34A1 SLC16A7 EMB SLC13A1 SLC13A2 SLC13A3 SLC22A12 SLC13A4 SLC22A6 SLC2A13 SLC22A8 SLC47A2 SLC22A7 SLC47A1 SLC22A11 SLC41A2 SLC5A11 SLC41A1 SLC30A10 SLC5A3 SLC13A5 SLC14A1 SLC10A6 ALB SLC14A2 SLC31A1 SLC39A10 SLC39A14 SLC39A6 SLC39A5 SLC3A2 SLC39A8 RHCG RHBG SLC39A7 SLC39A2 SLC39A1 SLC39A4 SLC39A3 SLC16A1 SLC16A8 SLC16A3 SLC30A7 SLC30A6 SLC30A8 SLC30A3 ARL2 SLC30A2 SLC9A1 SLC30A5 SLCO1B1 SLC30A1 SLCO1B3 SLCO1A2 SLC22A4 RSC1A1 SLC22A15 SLC22A16 SLC22A18 SLC2A8 SLC26A2 RHAG SLC26A1 SLC2A9 SLC11A1 SLC2A14 SLC2A1 SLC45A3 SLC2A2 SLC2A11 SLC8A1 SLC2A3 SLC2A10 SLC8A2 SLC25A10 SLC2A12 SLC5A10 SLC40A1 SLC50A1 SLC2A4 SLC5A1 HEPH SLC5A2 SLC2A6 SLC2A7 SLC5A4 SLC5A9 KIAA1919 SLC6A3 SLC11A2 SLC24A1 SLC32A1 CP SLC35B3 SLC17A7 SLC17A8 SLC35B2 SLC7A5 SLC5A7 SLC17A5 SLC38A1 SLC1A1 SLC1A2 SLC1A3 SLC27A1 SLC1A6 SRI SLC22A3 SLC1A7 SLC22A5 SLC35D1 SLC38A2 SLC22A2 SLC22A1 SLC35D2 SLC18A2 RUNX1 SLC8A3 SLC6A20 SLC6A13 SLC6A12 SLC6A11 SLC6A1 SLC12A2 SLC12A3 SLC12A4 SLC12A5 SLC12A1 SLC12A6 SLC12A7 AHCYL2 SLC4A1 SLC4A2 SLC4A3 SLC4A4 SLC4A5 SLC26A11 SLC6A19 SLC15A1 SLC25A5 SLC6A18 SLC25A4 SLC15A2 SLC25A6 SLC6A15 SLC6A14 SLC36A4 SLC9A2 SLC9A3 SLC9A4 SLC9A5 SLC9A6 SLC9A7 SLC9A8 SLC9A9 FGF21 SLC1A4 SLC1A5 SLC38A3 SLC15A3 SLC15A4 SLC38A5 SLC38A4 SLC4A10 BSG SLC16A10 SLC6A6 SLC26A7 SLC26A9 SLC26A4 SLC26A3 SLC26A6 SLC7A11 SLC7A10 SLC36A1 SLC36A2 SLC7A6 DEFECTIVE SLCO1B3 CAUSES HYPERBILIRUBINEMIA, ROTOR TYPE (HBLRR)%REACTOME%R-HSA-5619058.2 Defective SLCO1B3 causes hyperbilirubinemia, Rotor type (HBLRR) SLCO1B3 FRUCTOSE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 72%5652227 Fructose biosynthesis AKR1B1 SORD P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME%R-HSA-69613.2 p53-Independent G1 S DNA damage checkpoint PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 UBA52 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 UBB PSMB3 UBC PSMB1 PSMF1 RPS27A CHEK2 SHFM1 CHEK1 PSMB8 PSMB9 PSMC5 CDC25A PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 RIPK1-MEDIATED REGULATED NECROSIS%REACTOME DATABASE ID RELEASE 72%5213460 RIPK1-mediated regulated necrosis RIPK3 BIRC2 MLKL BIRC3 XIAP CASP8 TRADD TNFSF10 FAS TNFRSF10B FASLG RIPK1 TNFRSF10A TRAF2 FADD SIGNALING BY ERBB4%REACTOME%R-HSA-1236394.4 Signaling by ERBB4 NCSTN APH1B APOE WWOX DLG4 GABRG3 GABRG2 UBA52 PSENEN WWP1 SPARC ITCH STMN1 YAP1 STAT5A ADAM17 UBB ADAP1 GABRB3 CSN2 GABRB2 GABRB1 MXD4 UBC RPS27A NRG1 NRG2 NRG3 NEDD4 NRG4 ESR1 EGF SHC1 PIK3R1 EGFR PIK3CA SOS1 S100B GABRQ GABRA1 NCOR1 HRAS BTC NRAS GFAP HBEGF EREG PGR SRC PSEN2 TAB2 PSEN1 CXCL12 APH1A NEUROTRANSMITTER RELEASE CYCLE%REACTOME%R-HSA-112310.5 Neurotransmitter release cycle CASK SLC1A2 SLC1A3 LIN7A SYN3 SLC1A6 LIN7C SLC1A7 CPLX1 LIN7B SYN1 SLC38A2 RIMS1 SLC22A2 BZRAP1 PPFIA1 SLC22A1 APBA1 PPFIA4 STX1A SLC18A2 ABAT VAMP2 PPFIA3 ARL6IP5 PPFIA2 GLS2 DNAJC5 SLC6A13 SLC6A12 CHAT GLS SLC6A11 SLC6A1 HSPA8 MAOA SLC18A3 SLC32A1 ALDH5A1 SLC17A7 SLC5A7 GAD1 GAD2 NAAA UNC13B SNAP25 SLC1A1 RAB3A SYT1 DEFECTIVE CYP4F22 CAUSES ICHTHYOSIS, CONGENITAL, AUTOSOMAL RECESSIVE 5 (ARCI5)%REACTOME DATABASE ID RELEASE 72%5579005 Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5) CYP4F22 ESCAPE OF MTB FROM THE PHAGOCYTE%REACTOME DATABASE ID RELEASE 72%9637679 Escape of Mtb from the phagocyte SIGNALING BY PDGFRA TRANSMEMBRANE, JUXTAMEMBRANE AND KINASE DOMAIN MUTANTS%REACTOME%R-HSA-9673767.1 Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants PIK3R1 PIK3CB HRAS STAT1 PIK3CA PIK3R2 STAT3 SOS1 NRAS PDGFRA IRAK4 DEFICIENCY (TLR5)%REACTOME DATABASE ID RELEASE 72%5603037 IRAK4 deficiency (TLR5) TLR10 TLR5 IRAK4 MYD88 TANDEM OF PORE DOMAIN IN A WEAK INWARDLY RECTIFYING K+ CHANNELS (TWIK)%REACTOME DATABASE ID RELEASE 72%1299308 Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK) KCNK1 KCNK6 KCNK7 DNA REPLICATION INITIATION%REACTOME DATABASE ID RELEASE 72%68952 DNA replication initiation POLE POLE4 PRIM2 POLA1 PRIM1 POLA2 POLE2 POLE3 PHYSIOLOGICAL FACTORS%REACTOME DATABASE ID RELEASE 72%5578768 Physiological factors NPPC NPR1 HIPK1 NPR2 NPPA GATA4 TBX5 HIPK2 KAT2B NKX2-5 CORIN WWTR1 FANCONI ANEMIA PATHWAY%REACTOME%R-HSA-6783310.2 Fanconi Anemia Pathway RPA1 RPA2 STRA13 FAAP100 APITD1 RPA3 FANCD2 DCLRE1B DCLRE1A FAN1 EME1 EME2 UBA52 SLX1B FANCI ATRIP POLN FANCC SLX1A WDR48 FANCM ERCC4 FANCL ERCC1 FANCA UBB FANCB FANCE ATR FANCG UBC FANCF RPS27A UBE2T MUS81 FAAP24 FAAP20 SLX4 USP1 SIGNALING BY NTRK2 (TRKB)%REACTOME DATABASE ID RELEASE 72%9006115 Signaling by NTRK2 (TRKB) HRAS DOCK3 FRS2 PTPN11 GRIN2B FRS3 CDK5 NRAS CDK5R1 GAB1 PIK3R1 PIK3CA PLCG1 NTRK2 TIAM1 SOS1 BDNF NTF3 SRC RAC1 NTF4 REGULATION OF KIT SIGNALING%REACTOME%R-HSA-1433559.1 Regulation of KIT signaling KIT PTPN6 LYN CBL YES1 PRKCA SOCS6 SOS1 SOCS1 SH2B3 FYN LCK DEFECTIVE ABCG5 CAUSES SITOSTEROLEMIA%REACTOME%R-HSA-5679096.1 Defective ABCG5 causes sitosterolemia ABCG8 ABCG5 DETOXIFICATION OF REACTIVE OXYGEN SPECIES%REACTOME%R-HSA-3299685.5 Detoxification of Reactive Oxygen Species AQP8 CYBB CYBA TXN2 GPX2 SOD3 GPX1 SOD1 CCS GPX3 GPX6 TXN GPX5 PRDX2 GPX8 GPX7 SOD2 PRDX1 ATOX1 NUDT2 ERO1L PRDX3 NCF1 NCF2 CYCS NCF4 P4HB TXNRD1 PRDX6 NOX4 NOX5 GSTP1 ATP7A CAT SULFIDE OXIDATION TO SULFATE%REACTOME DATABASE ID RELEASE 72%1614517 Sulfide oxidation to sulfate TSTD1 TST SUOX ETHE1 SQRDL SLC25A10 LOSS OF NLP FROM MITOTIC CENTROSOMES%REACTOME%R-HSA-380259.1 Loss of Nlp from mitotic centrosomes HAUS7 CEP70 PRKAR2B CEP72 CEP192 PCNT CEP76 YWHAG CLASP1 CEP78 PLK4 DYNC1H1 ODF2 CEP152 NDE1 NEDD1 FGFR1OP CEP41 OFD1 PPP2R1A PRKACA PLK1 CENPJ CDK1 TUBA4A CEP57 CETN2 TUBA1A CEP164 CCP110 ACTR1A PCM1 HSP90AA1 CNTRL CEP250 NEK2 NINL CEP290 CDK5RAP2 CEP135 TUBB CEP131 HAUS4 HAUS3 HAUS6 CSNK1D HAUS5 CSNK1E TUBG1 DYNLL1 CKAP5 HAUS2 HAUS1 AKAP9 CEP63 MAPRE1 YWHAE SFI1 TUBB4B PAFAH1B1 TUBB4A SDCCAG8 DYNC1I2 DCTN2 SSNA1 DCTN3 HAUS8 CELL REDOX HOMEOSTASIS%REACTOME%R-HSA-1222541.1 Cell redox homeostasis PLASMA LIPOPROTEIN ASSEMBLY%REACTOME%R-HSA-8963898.1 Plasma lipoprotein assembly ABCA1 MTTP APOE APOB APOC4 APOC1 P4HB APOC3 APOA2 APOA1 ZDHHC8 APOA4 PRKACG APOC2 PRKACA PRKACB SAR1B A2M TRNA PROCESSING%REACTOME%R-HSA-72306.6 tRNA processing C2orf49 TRMT13 TRMT11 ZBTB8OS DUS2 NUP107 CTU2 NUP188 CTU1 CPSF4 CPSF1 XPOT CSTF2 RPP30 RPP38 PUS3 NUP62 CDKAL1 CLP1 NDC1 NUP214 PUS7 RPP21 SEC13 RPP25 NUP133 NUP210 DDX1 RPP40 NUP93 NUP50 TSEN15 NUP54 TP53RK TSEN34 RPP14 EPRS TRDMT1 FAM98B POM121 NUP205 AAAS NUP160 NUP85 TPR NUP88 NUP43 RAE1 RANBP2 NUP155 NUP153 NUP35 NUPL2 NUP37 TRMT112 POP5 POP7 POP1 POP4 TSEN54 ALKBH8 QTRTD1 GTPBP3 KIAA1456 TRMU NSUN2 NSUN6 C14orf166 URM1 TRMT10C ELAC2 TRNT1 KIAA0391 TRMT10A ADAT1 TRMT1 ADAT2 TRMT6 RAN TSEN2 THG1L FTSJ1 THADA WDR4 MTO1 QTRT1 LAGE3 TPRKB TRIT1 TRMT61A TRMT61B RTCB HSD17B10 TRMT44 TYW5 METTL1 TRMT5 TYW3 TYW1 OSGEP TRMT12 LCMT2 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1%REACTOME%R-HSA-349425.2 Autodegradation of the E3 ubiquitin ligase COP1 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 UBA52 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 UBB PSMB3 RFWD2 UBC PSMB1 PSMF1 RPS27A SHFM1 PSMB8 PSMB9 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 TP53 ATM PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 DUAL INCISION IN TC-NER%REACTOME%R-HSA-6782135.1 Dual incision in TC-NER POLK RPA1 POLE RPA2 POLD3 RFC1 POLD4 RPA3 AQR POLD1 POLR2E POLD2 POLR2F RFC5 POLR2H RFC3 RFC4 RFC2 ZNF830 POLR2K CCNH POLR2L XPA UBA52 GTF2H1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 ERCC3 ERCC2 ERCC6 EP300 CUL4A POLE4 ERCC4 ERCC1 TCEA1 POLE2 PRPF19 UBB POLE3 ERCC8 ERCC5 UBC CUL4B RPS27A DDB1 USP7 CDK7 POLR2A POLR2B POLR2C POLR2D XAB2 POLR2G MNAT1 POLR2I POLR2J HMGN1 PPIE UVSSA RBX1 ISY1 PCNA GLUTATHIONE SYNTHESIS AND RECYCLING%REACTOME DATABASE ID RELEASE 72%174403 Glutathione synthesis and recycling GGT7 CHAC2 GGT6 CHAC1 GGCT GGT1 GCLC GSS GCLM CNDP2 GGT5 OPLAH PEROXISOMAL LIPID METABOLISM%REACTOME DATABASE ID RELEASE 72%390918 Peroxisomal lipid metabolism HAO2 CROT ACOX2 ACOT6 ACOX3 ACOT4 ACAA1 EHHADH NUDT19 PECR DECR2 HSD17B4 ACOT8 AMACR ACOXL SLC25A17 ABCD1 SLC27A2 PHYH ACBD5 HACL1 ACBD4 NUDT7 CRAT BETA OXIDATION OF LAUROYL-COA TO DECANOYL-COA-COA%REACTOME DATABASE ID RELEASE 72%77310 Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA HADH HADHB HADHA ECHS1 ACADL PIWI-INTERACTING RNA (PIRNA) BIOGENESIS%REACTOME DATABASE ID RELEASE 72%5601884 PIWI-interacting RNA (piRNA) biogenesis POLR2A POLR2B POLR2C POLR2D POLR2G POLR2E POLR2F POLR2H POLR2I POLR2J POLR2K TDRKH POLR2L MOV10L1 PIWIL2 PIWIL1 PIWIL4 DDX4 HSP90AA1 MYBL1 HENMT1 MAEL TDRD12 FKBP6 ASZ1 TDRD9 TDRD6 TDRD1 PLD6 TOXICITY OF TETANUS TOXIN (TENT)%REACTOME DATABASE ID RELEASE 72%5250982 Toxicity of tetanus toxin (TeNT) VAMP2 METABOLISM OF STEROID HORMONES%REACTOME%R-HSA-196071.2 Metabolism of steroid hormones SRD5A1 SRD5A3 CGA BZRAP1 LHB AKR1B1 TSPO HSD3B2 HSD3B1 CYP11A1 HSD11B1 HSD11B2 POMC STARD3NL SERPINA6 STAR CYP21A2 AKR1B15 FDXR CYP11B2 CYP11B1 HSD17B14 HSD17B3 STARD3 HSD17B12 STARD4 HSD17B11 STARD6 CYP17A1 HSD17B1 CYP19A1 HSD17B2 FDX1 FDX1L SRD5A2 ACTIVATION OF AMPA RECEPTORS%REACTOME%R-HSA-399710.1 Activation of AMPA receptors GRIA2 GRIA3 GRIA1 GRIA4 ERKS ARE INACTIVATED%REACTOME DATABASE ID RELEASE 72%202670 ERKs are inactivated PPP2CA PPP2CB DUSP4 PPP2R5D DUSP3 VRK3 DUSP6 DUSP7 PPP2R1B PPP2R1A MAPK7 MAPK1 MAPK3 PI3K EVENTS IN ERBB2 SIGNALING%REACTOME DATABASE ID RELEASE 72%1963642 PI3K events in ERBB2 signaling NRG1 NRG2 BTC NRG3 NRG4 HBEGF EREG EGF GAB1 PIK3R1 EGFR PIK3CA ERBB2 CAM-PDE 1 ACTIVATION%REACTOME DATABASE ID RELEASE 72%111957 Cam-PDE 1 activation PDE1C PDE1A PDE1B CA2+ PATHWAY%REACTOME DATABASE ID RELEASE 72%4086398 Ca2+ pathway CAMK2A PRKCA ITPR1 ITPR2 ITPR3 WNT11 GNAT2 FZD3 PRKG2 PLCB3 CTNNB1 PLCB1 PLCB2 NLK PRKG1 TNRC6C GNG10 PPP3R1 PDE6G GNG12 GNG11 GNG13 TNRC6A GNAO1 TNRC6B PDE6B PDE6A GNB2 GNB1 TCF7 GNB4 TCF7L2 GNB3 GNB5 GNGT1 GNGT2 LEF1 TCF7L1 FZD4 FZD6 MOV10 PPP3CA AGO3 PPP3CB AGO4 AGO1 NFATC1 AGO2 GNG3 GNG2 GNG5 FZD2 GNG4 FZD5 WNT5A GNG7 GNG8 MAP3K7 ACTIVATED NTRK2 SIGNALS THROUGH PLCG1%REACTOME%R-HSA-9026527.1 Activated NTRK2 signals through PLCG1 PLCG1 NTRK2 BDNF NTF4 DISEASES OF MISMATCH REPAIR (MMR)%REACTOME DATABASE ID RELEASE 72%5423599 Diseases of Mismatch Repair (MMR) MLH1 MSH2 PMS2 MSH6 MSH3 DEFECTIVE CYP27A1 CAUSES CEREBROTENDINOUS XANTHOMATOSIS (CTX)%REACTOME%R-HSA-5578996.3 Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX) CYP27A1 CROSSLINKING OF COLLAGEN FIBRILS%REACTOME%R-HSA-2243919.2 Crosslinking of collagen fibrils LOXL3 LOXL4 PCOLCE LOX PXDN LOXL1 LOXL2 BMP1 TLL2 TLL1 BBSOME-MEDIATED CARGO-TARGETING TO CILIUM%REACTOME DATABASE ID RELEASE 72%5620922 BBSome-mediated cargo-targeting to cilium BBS7 BBS5 BBS4 MKKS SSTR3 LZTFL1 BBS10 BBS12 ARL6 MCHR1 CCT8 BBS2 CCT5 BBS1 CCT4 RAB3IP BBIP1 CCT3 CCT2 TTC8 TCP1 SMO BBS9 HEDGEHOG 'ON' STATE%REACTOME%R-HSA-5632684.1 Hedgehog 'on' state PSMD3 PSMD1 KIF3A PTCH1 PSMA5 PSMA6 PSMA3 PSMA4 GLI1 PSMA1 GLI3 GLI2 PSMA2 ARRB2 PSME3 SUFU PSME4 PSME1 PSME2 KIF7 UBA52 HHIP NUMB PSMD10 PSMB11 ULK3 PSMD12 SHH PSMD11 DZIP1 EFCAB7 PSMD14 DHH IHH BOC IQCE PSMD13 ARRB1 EVC SPOPL PSMA7 GAS1 PSMB10 CSNK1A1 GAS8 PSMA8 ADRBK1 SPOP ITCH EVC2 PSMB6 PSMB7 SMURF2 PSMB4 PSMB5 PSMB2 UBB PSMB3 UBC PSMB1 PSMF1 RPS27A SHFM1 PSMB8 PSMB9 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 CDON CDC73 SMURF1 CUL3 PSMD8 PSMD9 PSMD6 RBX1 PSMD7 PSMD4 PSMD5 SMO PSMD2 GPR161 FORMATION OF THE EDITOSOME%REACTOME%R-HSA-75094.2 Formation of the Editosome APOBEC3H A1CF APOBEC3A APOBEC3B APOBEC1 APOBEC3C APOBEC2 APOBEC4 RAS ACTIVATION UPON CA2+ INFLUX THROUGH NMDA RECEPTOR%REACTOME%R-HSA-442982.3 Ras activation upon Ca2+ influx through NMDA receptor CAMK2D CAMK2A NEFL HRAS GRIN2B GRIN2D GRIN1 CAMK2G NRAS RASGRF2 LRRC7 DLG2 DLG1 ACTN2 DLG4 DLG3 RASGRF1 CAMK2B ABACAVIR TRANSPORT AND METABOLISM%REACTOME DATABASE ID RELEASE 72%2161522 Abacavir transport and metabolism ADH1A SLC22A3 ADAL ABCB1 SLC22A2 PCK1 ABCG2 GUK1 SLC22A1 NT5C2 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION%REACTOME DATABASE ID RELEASE 72%948021 Transport to the Golgi and subsequent modification CNIH3 MCFD2 RAB1B SEC24B PPP6C DCTN4 PPP6R1 SEC24A PPP6R3 TRAPPC6A TRAPPC6B ANK2 ARCN1 GORASP1 CAPZA3 ANK3 SEC22A SEC22C MGAT4C CAPZA1 MGAT4A CAPZA2 MGAT4B FOLR1 COPG2 BET1 NSF COPG1 SEC24D ACTR10 SEC24C DYNC1LI1 DYNC1LI2 ARF4 CTSZ SAR1B SEC13 B4GALT2 B4GALT3 B4GALT1 NAPA DYNLL2 CTSC NAPB GOSR1 NAPG GBF1 DYNC1I1 GOLGA2 MAN2A2 MAN1A2 MAN2A1 GOLGB1 B4GALT6 MAN1C1 B4GALT4 B4GALT5 STX5 MAN1A1 YKT6 COG8 COG7 COG6 COG5 COG4 COG3 ACTR1A COG2 COG1 BET1L TMED2 ST8SIA6 ST6GAL1 CSNK1D ST8SIA2 TGFA ST8SIA3 AREG DYNLL1 ARF3 ARF1 CD59 MGAT2 CD55 DYNC1I2 DCTN2 DCTN3 DYNC1H1 LHB FUT3 SPTAN1 COL7A1 F5 F8 ST3GAL4 CGA SEC31A FUCA1 KDELR1 TRAPPC4 ANK1 KDELR2 SERPINA1 INS COPB2 SPTB COPA TMED10 SPTBN4 COPB1 SPTBN5 SPTA1 SPTBN1 SPTBN2 DCTN1 TFG LMAN1L GOSR2 LMAN2L COPE SCFD1 CHST10 MIA2 SEC23A MIA3 CAPZB CHST8 TMED3 STX17 USO1 LMAN1 LMAN2 TMED7 MGAT5 TMED9 MGAT3 MGAT1 COPZ2 TRAPPC10 SEC23IP MANEA ARFGAP3 TRAPPC2L TBC1D20 ARFGAP1 FUT8 COPZ1 TRAPPC2 ARFGAP2 ANKRD28 TRAPPC3 SEC16B SEC16A SEC22B PREB TRAPPC5 TRAPPC9 ARF5 TRAPPC1 CNIH1 KDELR3 TMEM115 DCTN6 GRIA1 RAB1A CNIH2 DCTN5 PTK6 ACTIVATES STAT3%REACTOME%R-HSA-8849474.1 PTK6 Activates STAT3 STAP2 PTK6 STAT3 SOCS3 EXTENSION OF TELOMERES%REACTOME DATABASE ID RELEASE 72%180786 Extension of Telomeres LIG1 RPA1 RPA2 POLD3 RTEL1 POLD4 RFC1 WRN RPA3 POLD1 POLD2 POLA1 RFC5 TINF2 POLA2 DNA2 RFC3 TERF2IP RFC4 RFC2 WRAP53 RUVBL1 DSCC1 CHTF18 OBFC1 DKC1 PRIM2 NHP2 PIF1 PRIM1 CHTF8 TERT GAR1 ACD CTC1 TEN1 NOP10 RUVBL2 TERF1 TERF2 POT1 FEN1 BLM PCNA DEFECTIVE MISMATCH REPAIR ASSOCIATED WITH MLH1%REACTOME%R-HSA-5545483.1 Defective Mismatch Repair Associated With MLH1 MLH1 PMS2 SUMO E3 LIGASES SUMOYLATE TARGET PROTEINS%REACTOME%R-HSA-3108232.5 SUMO E3 ligases SUMOylate target proteins RPA1 RARA TDG WRN NUP107 NUP188 SUZ12 SMC3 EID3 BIRC5 NUP62 NDC1 NUP214 RELA CDCA8 SEC13 DDX5 NUP133 NUP210 ZNF131 AURKB RAD52 ZNF350 AURKA UHRF2 CTBP1 RAD21 PARK7 BMI1 NUP93 RNF2 TRIM28 STAG1 NUP50 NRIP1 CBX8 STAG2 DDX17 NUP54 TFAP2B PHC2 MDC1 MITF PHC1 RING1 FOXL2 HIC1 CBX4 CBX2 SP3 NSMCE4A PCGF2 SMC1A TOP1 MBD1 MKL1 PML SAFB PHC3 INCENP POM121 NSMCE2 NUP205 NSMCE1 DAXX AAAS NUP160 ZBED1 NUP85 TPR NUP88 NUP43 HNRNPK HNRNPC RAE1 RANBP2 TP53 ESR1 NUP155 NFKB2 NUP153 SATB2 CETN2 NCOA1 NUP35 NUPL2 NCOA2 PPARGC1A CREBBP NUP37 TFAP2C SMC5 PPARG RXRA SMC6 PPARA UBE2I PGR BRCA1 SP100 NDNL2 SUMO1 SUMO3 SUMO2 HERC2 ING2 L3MBTL2 CBX5 PIAS4 XPC TP53BP1 NFKBIA XRCC4 IKBKG TOP2A IKBKE NPM1 TOPORS CDKN2A TRIM27 VDR VHL AR EP300 HIPK2 SATB1 RORA DNMT1 PARP1 RNF168 HIST1H4K HIST1H4L HIST1H4A NR3C1 HIST1H4B HIST1H4H HIST1H4I HIST1H4J HIST1H4C THRB HIST1H4D TOP2B RANGAP1 NR2C1 NR4A2 HIST1H4E NR5A1 HIST1H4F CHD3 PIAS3 SIN3A PIAS1 DNMT3B DNMT3A NCOR2 HDAC4 HDAC7 HIST4H4 NOP58 MDM2 HDAC2 NR1H2 HDAC1 NR3C2 HIST2H4A BLM HIST2H4B PCNA MTA1 REGULATION OF TP53 ACTIVITY THROUGH ACETYLATION%REACTOME DATABASE ID RELEASE 72%6804758 Regulation of TP53 Activity through Acetylation ING5 RBBP4 ING2 AKT1 BRD1 KAT6A RBBP7 MTA2 TP53 MEAF6 MBD3 CHD3 MAP2K6 BRPF1 GATAD2B BRPF3 TMEM55B BRD7 GATAD2A CHD4 EP300 PIN1 HDAC2 PML HDAC1 AKT2 AKT3 PIP4K2A PIP4K2B PIP4K2C INTERLEUKIN-4 AND INTERLEUKIN-13 SIGNALING%REACTOME DATABASE ID RELEASE 72%6785807 Interleukin-4 and Interleukin-13 signaling LAMA5 ITGAM ITGB2 CXCL8 ITGAX TIMP1 ZEB1 JAK2 CCL11 RORC IL23R PIM1 IL13RA2 IL13RA1 BIRC5 FGF2 IL12B IL12A FSCN1 IGHG4 IL23A NDN SOCS5 CCL2 MCL1 IGHG1 CEBPD TNFRSF1B TWIST1 CCL22 CCND1 IL2RG IGHE JAK3 OPRD1 BATF FOXO1 IL17F IL17A IL4R MMP1 MMP2 MMP3 OPRM1 FCER2 FOXO3 BCL2L1 S1PR1 IL6 BCL2 TP53 ANXA1 IL10 LCN2 CD36 POMC SAA1 NOS2 ICAM1 IL4 IL13 SOCS1 HSP90B1 CDKN1A IRF4 GATA3 POU2F1 MMP9 AKT1 VCAM1 NANOG IL18 IL1A IL1B PTGS2 RHOU F13A1 COL1A2 SOX2 FN1 JUNB HGF SOCS3 FOS RORA VIM JAK1 HSPA8 MYC HMOX1 MAOA STAT1 HIF1A PIK3R1 FASLG HSP90AA1 TGFB1 ALOX15 BCL6 MUC1 TNF LIF OSM TYK2 ALOX5 ITGB1 IL6R STAT6 STAT3 VEGFA LBP SYNTHESIS OF IPS IN THE ER LUMEN%REACTOME%R-HSA-1855231.2 Synthesis of IPs in the ER lumen MINPP1 CHYLOMICRON REMODELING%REACTOME%R-HSA-8963901.1 Chylomicron remodeling GPIHBP1 APOC3 APOA2 APOA1 LPL APOA4 APOA5 APOC2 APOE APOB METABOLISM OF SEROTONIN%REACTOME DATABASE ID RELEASE 72%380612 Metabolism of serotonin ALDH2 MAOA NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC)%REACTOME%R-HSA-975957.1 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) RPL26 RPL29 RPL10L RPS4X RPL10A RPL28 RPS3A RPL23A FAU RPL41 RPL3L PPP2R1A RPL10 RPL12 RPL13A RPL11 RPS3 RPL14 RPL13 NCBP1 NCBP2 RPS2 RPL15 RPL18 PPP2CA RPL17 RPL19 RPL27A RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS15 RPS14 RPS17 RPS16 RPS19 RPL18A RPL36AL RPS18 RPLP1 RPS11 RPS10 RPLP0 RPS13 RPS12 RPLP2 RPL7A RPS27L PABPC1 UBA52 RPL37A RPS26 RPS25 PPP2R2A RPS28 GSPT2 GSPT1 RPS27 UPF3A RPL36A SMG1 RPS29 SMG9 SMG7 RPS20 SMG8 RPL35A RPS21 SMG5 RPS24 SMG6 RPS23 UPF2 UPF1 ETF1 PNRC2 RPL22L1 RPS4Y2 RPS4Y1 RPS27A EIF4A3 CASC3 MAGOH DCP1A EIF4G1 RPL26L1 RPL4 RPL39L RBM8A RPL5 RPL30 RPL3 RPL32 RPL31 RPL34 RPL8 RPL9 RPL6 RPL7 UPF3B MAGOHB RPL36 RNPS1 RPL35 RPL38 RPL37 RPL39 RPS15A RPL21 RPL23 RPL22 RPL24 RPL27 SIGNALING BY NON-RECEPTOR TYROSINE KINASES%REACTOME DATABASE ID RELEASE 72%9006927 Signaling by Non-Receptor Tyrosine Kinases AKT1 ELMO1 ELMO2 CRK DOCK1 PXN UBA52 SOCS3 UBB BCAR1 CCND1 UBC RPS27A LRRK2 NR3C1 ARHGAP35 PELP1 NRG1 ARAP1 NRG2 DOK1 SFPQ CCNE1 NRG3 NRG4 KHDRBS1 KHDRBS2 KHDRBS3 EPAS1 HIF1A EGF GPNMB STAP2 PTPN1 CBL SRMS EGFR PTK6 CDK4 ERBB2 HRAS RASA1 BTC RHOA NRAS CDK2 HBEGF EREG CDKN1B STAT3 RAC1 TOXICITY OF BOTULINUM TOXIN TYPE C (BONT C)%REACTOME DATABASE ID RELEASE 72%5250971 Toxicity of botulinum toxin type C (BoNT C) STX1A SNAP25 STX1B METABOLISM OF STEROIDS%REACTOME DATABASE ID RELEASE 72%8957322 Metabolism of steroids SEC24B SEC24A TBL1X TM7SF2 LSS SLC10A1 SLC10A2 SEC24D SEC24C INSIG2 CH25H TBL1XR1 INSIG1 OSBPL9 OSBPL7 OSBPL6 SAR1B OSBPL3 OSBPL2 SERPINA6 BAAT NSDHL SREBF2 LBR HSD17B3 STARD3 HSD17B4 STARD4 HMGCS1 STARD5 GGPS1 HSD17B7 STARD6 CYP17A1 HSD17B1 HSD17B2 FASN CARM1 LGMN SC5D CYP8B1 ABCC3 PTGIS MSMO1 AKR1B1 ARV1 TSPO CYP51A1 HSD11B1 HSD11B2 NCOA1 POMC SCD NCOA2 CREBBP STARD3NL NCOA6 CYP21A2 AKR1D1 RXRA PPARA UBE2I AKR1C1 AKR1C3 ABCB11 AKR1C2 DHCR24 AKR1C4 ALB SUMO2 DHCR7 ACOX2 GPAM CYP46A1 ELOVL6 BZRAP1 LHB TGS1 PIAS4 ACACB HELZ2 ACACA HSD3B7 EBP HSD3B2 HSD3B1 CYP11A1 SMARCD3 GC SLC27A2 SLC27A5 FDPS VDR FABP6 CYP11B2 CYP11B1 CHD9 CYP7B1 OSBP KPNB1 SP1 CYP19A1 ACAT2 CYP7A1 SLCO1B1 SLCO1B3 PMVK OSBPL1A CYP27A1 CYP27B1 SRD5A2 SRD5A1 CYP24A1 SRD5A3 CYP2R1 CGA MVD SLCO1A2 NFYA FDFT1 MVK NFYB SQLE NFYC MBTPS1 SCAP RAN MBTPS2 PPAPDC2 STAR IDI1 AKR1B15 MTF1 SEC23A IDI2 FDXR HSD17B14 CUBN LRP2 MED1 ACOT8 HSD17B12 HSD17B11 AMACR NR1H4 CYP39A1 FDX1 FDX1L REGULATION OF MECP2 EXPRESSION AND ACTIVITY%REACTOME%R-HSA-9022692.1 Regulation of MECP2 expression and activity CAMK2D TNRC6A CAMK2A TNRC6B TBL1X CAMK2G HTT CAMK4 TBL1XR1 SIN3A PRKACA NCOR2 HDAC3 NCOR1 AURKB MOV10 AGO3 HIPK2 AGO4 AGO1 AGO2 LBR CREB1 HDAC2 HDAC1 TNRC6C FOXG1 GPS2 CAMK2B FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION%REACTOME%R-HSA-434316.2 Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion FFAR1 PLCB2 GNA14 GNA15 PLCB3 GNA11 GNAQ PLCB1 DEFECTIVE SLCO2A1 CAUSES PRIMARY, AUTOSOMAL RECESSIVE HYPERTROPHIC OSTEOARTHROPATHY 2 (PHOAR2)%REACTOME%R-HSA-5619095.1 Defective SLCO2A1 causes primary, autosomal recessive hypertrophic osteoarthropathy 2 (PHOAR2) SLCO2A1 CLEAVAGE OF THE DAMAGED PYRIMIDINE%REACTOME DATABASE ID RELEASE 72%110329 Cleavage of the damaged pyrimidine TDG TINF2 NEIL3 TERF2IP NEIL2 NEIL1 HIST1H2AE NTHL1 HIST1H2AD HIST3H2BB HIST1H2AC ACD HIST1H2AB HIST1H2AJ HIST1H2BF HIST1H2BE SMUG1 HIST1H2BH HIST1H2BG HIST1H2BB HIST1H2BA HIST1H2BD OGG1 HIST1H2BC H2AFB1 HIST3H3 TERF1 TERF2 POT1 HIST1H4K HIST1H4L H2BFS HIST1H4A MBD4 HIST1H4B HIST1H4H HIST1H4I HIST1H4J HIST1H4C HIST1H4D HIST1H4E HIST1H4F HIST2H2AA3 HIST2H2AA4 HIST2H2AC H2AFJ H2AFZ H2AFX H2AFV HIST2H2BE HIST4H4 HIST1H2BN HIST1H2BM HIST1H2BO HIST1H2BJ HIST1H2BI HIST1H2BL HIST1H2BK HIST2H4A HIST2H4B DEFECTIVE BASE EXCISION REPAIR ASSOCIATED WITH OGG1%REACTOME%R-HSA-9656249.2 Defective Base Excision Repair Associated with OGG1 OGG1 PHOSPHOLIPID METABOLISM%REACTOME DATABASE ID RELEASE 72%1483257 Phospholipid metabolism VAC14 LPGAT1 PITPNB CPNE7 CPNE6 LCLAT1 PLB1 LIPI LIPH CPNE1 CPNE3 TMEM55B MFSD2A DGAT2 PCYT2 CSNK2A1 DGAT1 STARD7 CSNK2A2 HRASLS2 PISD PLA2G15 GNPAT PLA2G16 PHOSPHO1 GPD2 PLA2G10 GPD1 CSNK2B PLBD1 HRASLS5 PLA2R1 PLA1A CDS1 ABHD4 ABHD3 CHAT PLA2G3 RUFY1 PLD4 PLD6 PLA2G5 PLD1 PLA2G6 PNPLA7 PLD3 PLD2 PGS1 PTDSS2 PTDSS1 PTPMT1 OSBPL8 TMEM86B MTMR1 CHKB PNPLA6 MTMR2 OSBPL5 CHKA MTMR3 INPPL1 RARRES3 STARD10 EPT1 DGAT2L6 CRLS1 PEMT MTMR8 ALPI MTMR9 CDS2 FIG4 SLC44A5 MTMR4 ACHE SLC44A3 ENPP6 SLC44A4 SLC44A1 TPTE2 MTMR6 SLC44A2 LPCAT1 MTMR7 PCTP TAZ OSBPL10 ACP6 FAM73A FAM73B PLA2G12A PLA2G4F PCYT1B PCYT1A PLA2G4D PLA2G4B PLA2G4C PLA2G4A GPCPD1 HADHB HADHA PITPNM1 PITPNM3 PITPNM2 MGLL AGPAT5 AGPAT6 AGPAT9 PLA2G1B AGPAT1 ARF3 AGPAT2 ARF1 AGPAT3 AGPAT4 AWAT2 GPAT2 TNFAIP8 CEPT1 CDIPT PLA2G2F BCHE PLA2G2D PLA2G2E AGK PNPLA8 MBOAT7 PLA2G2A DDHD2 MBOAT1 MBOAT2 DDHD1 ETNPPL GPAM LPCAT4 ETNK2 LPCAT3 ETNK1 LPCAT2 PNPLA3 CHPT1 GPD1L LPIN1 LPIN2 LPIN3 PNPLA2 RAB5A PI4K2B PTPN13 GDE1 PI4K2A SACM1L INPP4A INPP4B PIK3CD INPP5F INPP5D PIK3CG INPP5E INPP5J PIK3R1 INPP5K PIK3CA PIK3C3 TNFAIP8L1 TNFAIP8L3 TNFAIP8L2 OCRL MTM1 RAB4A SYNJ2 SYNJ1 PIK3C2G PIK3R4 PIK3C2A PIK3R3 PIP5K1A PIP5K1B PIK3C2B PIP5K1C PIK3R6 PIK3R5 PIP4K2A PIP4K2B MTMR10 PIP4K2C MTMR12 MTMR14 TPTE RAB14 PIKFYVE PLEKHA1 PIK3CB PLEKHA5 PLEKHA6 PLEKHA3 PLEKHA4 PLEKHA8 SBF1 SBF2 PIK3R2 BMX GDPD1 GDPD3 GDPD5 PI4KB PTEN M PHASE%REACTOME%R-HSA-68886.3 M Phase RAB1B PRKAR2B YWHAG PPP2R5C ERCC6L OFD1 ZWILCH BUB1B CASC5 SMC3 CDC20 PTTG1 KNTC1 DYNC1LI1 BIRC5 DYNC1LI2 CLIP1 ZW10 MAD1L1 CDCA5 CSNK2A1 CDCA8 PDS5B PDS5A CSNK2A2 PMF1 SKA1 AURKB SKA2 DSN1 RAD21 RCC2 NDC80 ZWINT STAG1 KIF18A CSNK2B STAG2 SGOL2 SGOL1 NUF2 WAPAL SPDL1 NDEL1 NUDC SMC1A DYNLL2 ESPL1 KIF2A INCENP KIF2C KIF2B ITGB3BP MIS12 CENPA NSL1 CENPC BUB3 BUB1 DYNC1I1 CLASP2 CENPT CENPU CENPE CENPF CENPH CENPI TAOK1 CENPK CENPL CHMP2A CENPM CENPN B9D2 CENPO CENPP CENPQ SPC24 MAD2L1 SPC25 LPIN1 LPIN2 NEK9 LPIN3 NEK6 NEK7 MAU2 NIPBL TUBB6 ANAPC15 ANAPC16 TUBB3 ANAPC7 TUBB1 UBE2C PLK1 UBE2E1 UBE2D1 ANAPC10 ANAPC11 CCNB1 CDC23 CDC26 CDC27 CDC16 CDK1 ANAPC4 TUBA4B ANAPC5 ANAPC1 TUBA4A ANAPC2 KPNB1 RB1 FBXO5 TUBA8 TUBA1C TUBA1B TUBA1A TUBB2B TUBB2A TUBAL3 TUBA3E TUBB4B TUBB4A NUP107 NUP188 BANF1 PPP2R1B PPP2R1A NUP62 PRKACA NDC1 NUP214 SEC13 NUP133 NUP210 PPP2R5D NUP93 NUP50 NUP54 ANKLE2 EMD VRK1 LEMD3 SIRT2 POM121 NUP205 AAAS NUP160 PPP2CA PPP2CB NUP85 TPR NUP88 NUP43 RAE1 RANBP2 NUP155 NUP153 NUP35 NUPL2 NUP37 SUMO1 PRKCB VPS4A CHMP2B CHMP4C CHMP4B CHMP3 CHMP4A CHMP6 CHMP7 MAPK1 AHCTF1 RANGAP1 RCC1 RAN TUBB8P12 TUBB8 HSP90AA1 SPAST LEMD2 CC2D1B LMNB1 GOLGA2 CEP57 CETN2 CEP164 CCP110 ACTR1A PCM1 CNTRL CEP250 NEK2 NINL CEP290 CDK5RAP2 CEP135 TUBB CEP131 HAUS4 HAUS3 HAUS6 CSNK1D HAUS5 UBE2I CSNK1E TUBG1 DYNLL1 CKAP5 HAUS2 HAUS1 AKAP9 CEP63 MAPRE1 SFI1 PAFAH1B1 SDCCAG8 DYNC1I2 DCTN2 SSNA1 DCTN3 CCNB2 HAUS8 HAUS7 CEP70 CEP72 CEP192 PCNT CEP76 CLASP1 CEP78 PLK4 DYNC1H1 ODF2 CEP152 NDE1 NEDD1 FGFR1OP CEP41 SMC4 SMC2 HIST1H2AE EML4 HIST1H2AD HIST3H2BB NCAPG ARPP19 HIST1H2AC NCAPH HIST1H2AB NCAPH2 NCAPG2 HIST1H2AJ ENSA NCAPD2 NCAPD3 HIST2H3A CTDNEP1 HIST1H2BF NUMA1 HIST1H2BE CNEP1R1 HIST1H2BH HIST1H2BG MASTL HIST2H3D MCPH1 HIST1H2BB PPP2R2D HIST1H2BA HIST2H3C HIST1H2BD HIST1H2BC H2AFB1 HIST1H3J HIST1H3A HIST1H3F HIST1H3G HIST1H3H HIST1H3I HIST1H3B HIST1H3C HIST1H3D HIST1H3E H3F3B HIST1H4K HIST1H4L H3F3A H2BFS HIST1H4A HIST1H4B HIST1H4H HIST1H4I HIST1H4J APITD1 HIST1H4C HIST1H4D HIST1H4E HIST1H4F HIST2H2AA3 HIST2H2AA4 HIST2H2AC H2AFJ H2AFZ H2AFX H2AFV HIST2H2BE USO1 HIST4H4 IST1 HIST1H2BN HIST1H2BM HIST1H2BO HIST1H2BJ HIST1H2BI HIST1H2BL HIST1H2BK HIST2H4A HIST2H4B PPP1CC GORASP1 RAB2A GORASP2 BLZF1 LBR HIST3H3 TUBGCP2 TUBGCP5 TUBGCP6 TUBGCP3 TUBGCP4 TUBG2 MZT2B MZT2A NME7 SETD8 MZT1 PSMD8 PSMD9 PSMD6 XPO1 PSMD7 PSMD4 PSMD5 PSMD2 PPP2R5E PSMD3 PSMD1 TNPO1 PPP2R5B PPP2R5A PRKCA PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 UBA52 PSMD10 PSMB11 PSMD12 SET PPP2R2A PSMD11 RPS27 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 CENPJ PSMB5 PSMB2 UBB PSMB3 UBC PSMB1 PSMF1 RPS27A SHFM1 PSMB8 PSMB9 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 KIF20A KIF23 YWHAE RAB1A ASSEMBLY AND CELL SURFACE PRESENTATION OF NMDA RECEPTORS%REACTOME%R-HSA-9609736.3 Assembly and cell surface presentation of NMDA receptors CASK CAMK2D LIN7A CAMK2A LIN7C NEFL LIN7B CAMK2G APBA1 LRRC7 DLG2 DLG1 ACTN2 NBEA DLG4 DLG3 GRIN2A GRIN2C GRIN2B GRIN2D GRIN1 GRIN3B GRIN3A KIF17 CAMK2B DEFECTIVE SLC5A2 CAUSES RENAL GLUCOSURIA (GLYS1)%REACTOME%R-HSA-5658208.2 Defective SLC5A2 causes renal glucosuria (GLYS1) SLC5A2 SCAVENGING OF HEME FROM PLASMA%REACTOME DATABASE ID RELEASE 72%2168880 Scavenging of heme from plasma ALB IGKV3-11 IGKV1-12 CD163 LRP1 HP IGKV2D-28 IGKV4-1 HBB IGKV2-28 IGHA1 IGKV2D-30 APOA1 JCHAIN IGKV5-2 HPR IGKV3D-20 HBA2 HPX AMBP HBA1 APOL1 GABA RECEPTOR ACTIVATION%REACTOME DATABASE ID RELEASE 72%977443 GABA receptor activation KCNJ2 KCNJ4 KCNJ12 GNAL GABRG3 GABRG2 ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 NPTN ADCY7 ADCY6 ADCY5 ARHGEF9 GNAT3 GABRB3 GABRB2 GABRB1 GNG10 GABRR3 GABRR2 GNG12 GNG11 GABRR1 GNG13 KCNJ3 KCNJ5 GNB2 KCNJ6 KCNJ10 GNB1 GNB4 KCNJ9 KCNJ15 GNB3 KCNJ16 GNB5 GNGT1 GNGT2 GABRA2 GABRQ GABRA1 GABBR2 GABBR1 GABRA6 GABRA5 GABRA4 GNAI3 GNAI1 GNAI2 GABRA3 GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 ADCY9 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1%REACTOME%R-HSA-174113.3 SCF-beta-TrCP mediated degradation of Emi1 PSMD3 CUL1 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 UBA52 CDC20 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 UBB PSMB3 UBC PSMB1 PSMF1 RPS27A SHFM1 PSMB8 FBXO5 PSMB9 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 FZR1 BTRC SKP1 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 INTERACTIONS OF REV WITH HOST CELLULAR PROTEINS%REACTOME DATABASE ID RELEASE 72%177243 Interactions of Rev with host cellular proteins NUP85 TPR NUP88 NUP43 RANGAP1 RCC1 RAE1 RANBP2 NUP107 NUP155 NUP188 RANBP1 NUP153 RAN NUP62 NUP35 NUPL2 NDC1 NPM1 NUP214 SEC13 NUP37 NUP133 NUP210 NUP93 NUP50 NUP54 KPNB1 POM121 XPO1 NUP205 AAAS NUP160 INSERTION OF TAIL-ANCHORED PROTEINS INTO THE ENDOPLASMIC RETICULUM MEMBRANE%REACTOME DATABASE ID RELEASE 72%9609523 Insertion of tail-anchored proteins into the endoplasmic reticulum membrane HMOX1 SERP1 SEC61G SEC61B BAG6 OTOF STX1A STX5 VAMP2 GET4 CAMLG WRB ASNA1 UBL4A EMD VAPA SGTA APP PRNP EVASION OF OXIDATIVE STRESS INDUCED SENESCENCE DUE TO P16INK4A DEFECTS%REACTOME%R-HSA-9632693.3 Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects CDK6 CDK4 CDKN2A WAX BIOSYNTHESIS%REACTOME%R-HSA-9640463.1 Wax biosynthesis AWAT1 AWAT2 FAR1 FAR2 DISORDERS OF TRANSMEMBRANE TRANSPORTERS%REACTOME DATABASE ID RELEASE 72%5619115 Disorders of transmembrane transporters SLC7A7 OS9 SLC7A9 SLC24A4 SLC20A2 SLC3A1 NUP107 NUP188 RNF185 SLC26A2 HK1 RHAG SLC24A5 NUP62 SLC2A9 NDC1 NUP214 SEC13 NUP133 NUP210 ABCD4 NUP93 NUP50 SLC2A1 SLC2A2 NUP54 SLC2A10 SLC6A2 SLC6A5 SLC40A1 SLC5A1 HEPH SLC5A2 APOA1 SLC35A2 ABCG8 SLC35A1 ABCG5 POM121 SLC6A3 SLC35A3 SLC35C1 NUP205 ABCD1 SLC33A1 SLC11A2 AAAS SLC24A1 NUP160 SLCO2A1 NUP85 ABCC2 TPR ABCC8 NUP88 AVP NUP43 SLC29A3 RAE1 ABCB4 RANBP2 SLC27A4 GCKR NUP155 NUP153 GCK ABCA3 CP SLC5A5 AVPR2 NUP35 AVPR1B NUPL2 AVPR1A SLC17A8 SLC5A7 NUP37 SLC34A3 SLC34A2 SLC34A1 SLC17A5 ABCA1 SLC22A12 PSMD8 PSMD9 ABCB11 PSMD6 ABCC9 PSMD7 PSMD4 PSMD5 SLC1A1 PSMD2 PSMD3 SLC1A3 PSMD1 SLC22A5 PSMA5 SLC3A2 PSMA6 PSMA3 PSMA4 PSMA1 SLC39A4 PSMA2 PSME3 PSME4 PSME1 PSME2 UBA52 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 SLC16A1 PSMD13 PSMA7 KCNJ11 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 UBB PSMB3 SLC6A20 UBC PSMB1 PSMF1 RPS27A SHFM1 ABCA12 PSMB8 SLCO1B1 PSMB9 ABCB6 SLCO1B3 SLC12A3 PSMC5 PSMC6 PSMC3 SLC12A1 PSMC4 SLC12A6 PSMC1 PSMC2 ERLIN1 ERLIN2 ABCC6 DERL3 ERLEC1 SLC4A1 SLC4A4 SLC6A19 SLC6A18 SLC6A14 SLC9A6 SLC9A9 CFTR BSG VCP SLC26A4 SLC26A3 SEL1L DERL1 SLC22A18 DERL2 SLC36A2 RNF5 DEFECTIVE OGG1 SUBSTRATE BINDING%REACTOME DATABASE ID RELEASE 72%9656255 Defective OGG1 Substrate Binding OGG1 DISEASES OF IMMUNE SYSTEM%REACTOME%R-HSA-5260271.1 Diseases of Immune System IKBKB CHUK IRAK4 TIRAP TLR1 UNC93B1 TLR6 TLR2 NFKB1 NFKB2 TLR10 TLR5 BTK CD36 LY96 TICAM1 NFKBIA TRAF3 IKBKG CD14 TLR3 TLR4 MYD88 RELA TRANSPORT AND SYNTHESIS OF PAPS%REACTOME DATABASE ID RELEASE 72%174362 Transport and synthesis of PAPS SLC26A2 SLC26A1 PAPSS2 SLC35B3 PAPSS1 SLC35B2 LDL CLEARANCE%REACTOME%R-HSA-8964038.2 LDL clearance NPC2 APOB NCEH1 CLTC CLTA LDLR AP2A1 PCSK9 AP2B1 AP2A2 AP2S1 LIPA AP2M1 LDLRAP1 LSR SOAT1 CES3 NPC1 SOAT2 DEFECTIVE AVP DOES NOT BIND AVPR1A,B AND CAUSES NEUROHYPOPHYSEAL DIABETES INSIPIDUS (NDI)%REACTOME%R-HSA-5619099.3 Defective AVP does not bind AVPR1A,B and causes neurohypophyseal diabetes insipidus (NDI) AVP AVPR1B AVPR1A IKBKG DEFICIENCY CAUSES ANHIDROTIC ECTODERMAL DYSPLASIA WITH IMMUNODEFICIENCY (EDA-ID) (VIA TLR)%REACTOME%R-HSA-5603027.1 IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) IKBKB CHUK IKBKG NEF AND SIGNAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 72%164944 Nef and signal transduction PAK2 HCK DOCK2 ELMO1 FYN RAC1 LCK BREAKDOWN OF THE NUCLEAR LAMINA%REACTOME%R-HSA-352238.2 Breakdown of the nuclear lamina LMNB1 CASP6 LIGAND-RECEPTOR INTERACTIONS%REACTOME DATABASE ID RELEASE 72%5632681 Ligand-receptor interactions GAS1 PTCH1 HHIP SHH DHH BOC IHH CDON DEFECTIVE EXT1 CAUSES EXOSTOSES 1, TRPS2 AND CHDS%REACTOME DATABASE ID RELEASE 72%3656253 Defective EXT1 causes exostoses 1, TRPS2 and CHDS SDC4 SDC2 SDC3 GPC1 GPC3 GPC2 GPC5 GPC4 GPC6 EXT1 HSPG2 EXT2 SDC1 AGRN NTF3 ACTIVATES NTRK3 SIGNALING%REACTOME DATABASE ID RELEASE 72%9034013 NTF3 activates NTRK3 signaling NTF3 NTRK3 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES%REACTOME%R-HSA-380320.2 Recruitment of NuMA to mitotic centrosomes HAUS7 CEP70 PRKAR2B CEP72 CEP192 PCNT CEP76 YWHAG CLASP1 CEP78 PLK4 DYNC1H1 ODF2 CEP152 NDE1 NEDD1 FGFR1OP CEP41 OFD1 PPP2R1A PRKACA NUMA1 PLK1 CENPJ CDK1 TUBA4A CEP57 CETN2 TUBA1A CEP164 CCP110 ACTR1A PCM1 HSP90AA1 CNTRL CEP250 NEK2 NINL CEP290 CDK5RAP2 CEP135 TUBB CEP131 HAUS4 TUBGCP2 HAUS3 TUBGCP5 HAUS6 TUBGCP6 CSNK1D TUBGCP3 HAUS5 TUBGCP4 CSNK1E TUBG2 TUBG1 DYNLL1 MZT2B CKAP5 MZT2A HAUS2 NME7 HAUS1 AKAP9 CEP63 MAPRE1 MZT1 YWHAE SFI1 TUBB4B PAFAH1B1 TUBB4A SDCCAG8 DYNC1I2 DCTN2 SSNA1 DCTN3 HAUS8 GLYCOLYSIS%REACTOME%R-HSA-70171.6 Glycolysis GPI NUP107 NUP188 ADPGK ENO1 ENO2 ENO3 HK2 HK1 HK3 PPP2R1B PPP2R1A PRKACG NUP62 PRKACA PRKACB NDC1 NUP214 SEC13 TPI1 NUP133 NUP210 PGAM1 PGAM2 PPP2R5D BPGM PGM2L1 NUP93 NUP50 PGP GAPDHS NUP54 ALDOC ALDOB ALDOA GAPDH PFKFB2 PFKFB1 POM121 NUP205 PFKFB4 PFKFB3 AAAS NUP160 PPP2CA PPP2CB NUP85 TPR PGK1 NUP88 NUP43 PGK2 RAE1 RANBP2 GCKR NUP155 NUP153 GCK PFKL GNPDA1 GNPDA2 NUP35 NUPL2 PFKM PFKP NUP37 ONCOGENIC MAPK SIGNALING%REACTOME%R-HSA-6802957.4 Oncogenic MAPK signaling CAMK2D CAMK2A BCL2L11 MAP2K1 MAP2K2 BRAF RAF1 CAMK2G ITGA2B ARAF PEBP1 ARRB2 KIAA1549 MPRIP JAK2 TRIM24 KSR1 AGTRAP KSR2 SND1 APBB1IP CNKSR2 CNKSR1 PAPD7 ESRP1 CLCN6 VCL FAM114A2 ARRB1 ZC3HAV1 KRAS TRAK1 FXR1 RAP1B FGB ATG7 FGA MARK3 FN1 VWF QKI FAM131B AP3B1 AGGF1 RAP1A FGG BRAP MAPK1 MAPK3 MAP3K11 IQGAP1 SPRED3 SPRED2 PHB SPRED1 HRAS LMNA KDM7A PAPSS1 NRAS NF1 ITGB3 AKAP9 YWHAB SRC AGK CSK TLN1 CAMK2B SIGNALING BY PDGFRA EXTRACELLULAR DOMAIN MUTANTS%REACTOME%R-HSA-9673770.1 Signaling by PDGFRA extracellular domain mutants PIK3R1 PIK3CB HRAS STAT1 PIK3CA PIK3R2 STAT3 SOS1 NRAS PDGFRA PROCESSING OF CAPPED INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 72%75067 Processing of Capped Intronless Pre-mRNA ZNF473 CPSF4 CPSF7 CPSF1 CSTF3 SLBP CPSF3 CSTF2 CPSF2 CSTF2T WDR33 NUDT21 FIP1L1 PABPN1 CLP1 PCF11 PAPOLA SNRPD3 CSTF1 SYMPK SNRPG SNRPE SNRPF SNRPB LSM10 LSM11 NCBP1 NCBP2 CLOSTRIDIUM NEUROTOXICITY%REACTOME%R-HSA-168799.1 Clostridium neurotoxicity VAMP1 SYT2 SV2B SV2A STX1A SNAP25 SV2C STX1B VAMP2 SYT1 BIOSYNTHESIS OF E-SERIES 18(R)-RESOLVINS%REACTOME%R-HSA-9023661.1 Biosynthesis of E-series 18(R)-resolvins ALOX15 LTA4H ALOX5 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION)%REACTOME DATABASE ID RELEASE 72%2453902 The canonical retinoid cycle in rods (twilight vision) RHO ABCA4 RBP3 RDH11 TTR RDH12 HSD17B6 NAPEPLD SDR9C7 MYO7A LRAT DHRS9 HSD17B1 RDH10 RDH16 CYP4V2 RDH5 RBP4 RBP1 STRA6 RPE65 RLBP1 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX%REACTOME DATABASE ID RELEASE 72%445989 TAK1 activates NFkB by phosphorylation and activation of IKKs complex HMGB1 IKBKB NKIRAS1 NKIRAS2 CHUK RIPK2 UBE2N UBE2V1 NOD1 NFKB1 NOD2 NFKB2 AGER IRAK1 S100A12 APP S100B NFKBIA IKBKG SAA1 RELA NFKBIB IRAK2 TRAF6 TAB3 TAB2 TAB1 MAP3K7 AURKA ACTIVATION BY TPX2%REACTOME DATABASE ID RELEASE 72%8854518 AURKA Activation by TPX2 HAUS7 CEP70 PRKAR2B CEP72 CEP192 PCNT CEP76 YWHAG CLASP1 CEP78 PLK4 DYNC1H1 ODF2 CEP152 NDE1 NEDD1 FGFR1OP CEP41 OFD1 PPP2R1A HMMR PRKACA AURKA PLK1 CENPJ CDK1 TUBA4A CEP57 CETN2 TUBA1A CEP164 CCP110 ACTR1A PCM1 HSP90AA1 CNTRL CEP250 NEK2 NINL CEP290 CDK5RAP2 CEP135 TPX2 TUBB CEP131 HAUS4 HAUS3 HAUS6 CSNK1D HAUS5 CSNK1E TUBG1 DYNLL1 CKAP5 HAUS2 HAUS1 AKAP9 CEP63 MAPRE1 YWHAE SFI1 TUBB4B PAFAH1B1 TUBB4A SDCCAG8 DYNC1I2 DCTN2 SSNA1 DCTN3 HAUS8 CHYLOMICRON ASSEMBLY%REACTOME%R-HSA-8963888.1 Chylomicron assembly P4HB APOC3 APOA2 APOA1 MTTP APOA4 APOC2 APOE APOB SAR1B DEFECTIVE CYP17A1 CAUSES ADRENAL HYPERPLASIA 5 (AH5)%REACTOME DATABASE ID RELEASE 72%5579028 Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5) CYP17A1 TRANSCRIPTIONAL REGULATION BY THE AP-2 (TFAP2) FAMILY OF TRANSCRIPTION FACTORS%REACTOME%R-HSA-8864260.3 Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors KIT CGA KCTD15 APOE WWOX YY1 TFAP2D ESR1 TFAP2E CITED4 EGFR MYBL2 DEK ATAD2 NOP2 ERBB2 KDM5B HSPD1 NPM1 CREBBP TFAP2A EP300 TFAP2C CITED2 PITX2 TGFA UBE2I YEATS4 KCTD1 TFAP2B CDKN1A VEGFA MYC CITED1 SUMO1 DEFECTIVE MISMATCH REPAIR ASSOCIATED WITH MSH2%REACTOME%R-HSA-5632928.1 Defective Mismatch Repair Associated With MSH2 MSH2 MSH6 MSH3 RRNA MODIFICATION IN THE MITOCHONDRION%REACTOME%R-HSA-6793080.3 rRNA modification in the mitochondrion NSUN4 RNMTL1 MTERF4 FTSJ2 MRM1 TFB1M DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE%REACTOME%R-HSA-2559586.3 DNA Damage Telomere Stress Induced Senescence HMGA2 CABIN1 TINF2 TERF2IP CCNA2 HMGA1 CCNA1 HIST1H1D HIST1H1E HIST1H2AE HIST1H2AD HIST3H2BB HIST1H1A HIST1H2AC HIST1H1B ACD HIST1H2AB HIST1H1C HIST1H2AJ MRE11A HIST1H2BF HIST1H2BE HIST1H2BH HIST1H2BG HIST1H2BB ASF1A HIST1H2BA HIST1H2BD HIST1H2BC H2AFB1 H1F0 HIST3H3 TERF1 TERF2 KAT5 RAD50 RB1 NBN POT1 UBN1 HIST1H4K HIST1H4L H2BFS HIST1H4A HIST1H4B HIST1H4H LMNB1 HIST1H4I HIST1H4J CCNE2 HIST1H4C CCNE1 HIST1H4D HIST1H4E TP53 HIST1H4F HIST2H2AA3 EP400 HIST2H2AA4 HIST2H2AC H2AFJ H2AFZ H2AFX H2AFV HIST2H2BE ATM HIST4H4 CDK2 CDKN1A HIST1H2BN CDKN1B HIST1H2BM HIST1H2BO HIST1H2BJ HIRA HIST1H2BI HIST1H2BL HIST1H2BK HIST2H4A HIST2H4B DEFECTIVE GCLC CAUSES HEMOLYTIC ANEMIA DUE TO GAMMA-GLUTAMYLCYSTEINE SYNTHETASE DEFICIENCY (HAGGSD)%REACTOME%R-HSA-5578999.1 Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD) GCLC GCLM SIGNALING BY ROBO RECEPTORS%REACTOME DATABASE ID RELEASE 72%376176 Signaling by ROBO receptors RPL26 RPL29 AKAP5 RPS4X RPL28 PRKAR2A RPS3A RPL41 RPL3L SOS2 RPL10 RPL12 RPL11 RPS3 RPL14 RPL13 NCBP1 RPS2 NCBP2 RPL15 RPL18 RPL17 RPL19 CLASP2 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA DCC RPLP1 NTN1 RPLP0 RPLP2 CLASP1 RPL7A RPS27L MYO9B ABL2 CAP2 RPL37A RPL36A RPL35A ROBO2 NELL2 SLIT1 SLIT3 SLIT2 ROBO1 RPL22L1 VASP RPS4Y2 RPS4Y1 ENAH EVL CUL2 DAG1 RPL39L SOS1 FLRT3 PPP3CB ABL1 ZSWIM8 RHOA MSI1 RPS15A HOXA2 LHX3 LHX2 LHX4 LHX9 RPL10L RPL10A RPL23A FAU PAK7 PAK6 PAK4 PRKACG PFN1 PRKACA PRKACB USP33 ISL1 RPL13A CAP1 RPL27A ARHGAP39 RPS15 RPS14 RPS17 GPC1 RPS16 RPS19 RPL18A RPL36AL SRGAP3 RPS18 SRGAP1 RPS11 RPS10 RPS13 PSMD8 PSMD9 RPS12 PSMD6 PFN2 NCK2 SRC PSMD7 PSMD4 RAC1 PSMD5 CXCL12 NCK1 PSMD2 PSMD3 PSMD1 PRKCA PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 PABPC1 CXCR4 UBA52 RPS26 TCEB2 PSMD10 CDC42 PAK1 TCEB1 PSMB11 RPS25 PSMD12 RPS28 GSPT2 PSMD11 GSPT1 RPS27 PSMD14 UPF3A PSMD13 RPS29 PAK3 PSMA7 RPS20 PAK2 PSMB10 RPS21 PSMA8 RPS24 RPS23 UPF2 PSMB6 ETF1 PSMB7 PSMB4 PSMB5 PSMB2 COL4A5 UBB PSMB3 UBC PSMB1 PSMF1 RPS27A LDB1 SHFM1 PSMB8 PSMB9 PSMC5 PSMC6 EIF4A3 PSMC3 PSMC4 CASC3 PSMC1 MAGOH PSMC2 EIF4G1 NRP1 RPL26L1 RPL4 RBM8A RPL5 RPL30 RPL3 RPL32 RPL31 RPL34 RPL8 RPL9 RPL6 RPL7 UPF3B MAGOHB RPL36 RNPS1 RPL35 RPL38 RPL37 RPL39 RPL21 RPL23 RPL22 RBX1 RPL24 RPL27 RUNX1 AND FOXP3 CONTROL THE DEVELOPMENT OF REGULATORY T LYMPHOCYTES (TREGS)%REACTOME DATABASE ID RELEASE 72%8877330 RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) TNFRSF18 IL2 IL2RA NFATC2 CTLA4 IFNG CBFB CR1 FOXP3 RUNX1 NEUROPHILIN INTERACTIONS WITH VEGF AND VEGFR%REACTOME DATABASE ID RELEASE 72%194306 Neurophilin interactions with VEGF and VEGFR NRP2 FLT1 NRP1 KDR METABOLISM OF COFACTORS%REACTOME%R-HSA-8978934.2 Metabolism of cofactors GCHFR AKT1 NOS3 SPR IDH1 PRKG2 COQ9 COQ7 COQ6 COQ5 COQ3 GCH1 COQ2 DHFR HSP90AA1 PTS PDSS2 PDSS1 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM%REACTOME DATABASE ID RELEASE 72%2046104 alpha-linolenic (omega3) and linoleic (omega6) acid metabolism ACOT8 ELOVL5 ELOVL2 ELOVL3 FADS2 ACSL1 ACAA1 ABCD1 ELOVL1 SCP2 FADS1 HSD17B4 PKA ACTIVATION IN GLUCAGON SIGNALLING%REACTOME%R-HSA-164378.2 PKA activation in glucagon signalling PRKAR2B PRKAR2A GNAS ADCY4 ADCY3 PRKACG ADCY2 ADCY1 ADCY9 PRKACA ADCY8 PRKAR1B PRKACB ADCY7 ADCY6 PRKAR1A ADCY5 MECP2 REGULATES NEURONAL RECEPTORS AND CHANNELS%REACTOME DATABASE ID RELEASE 72%9022699 MECP2 regulates neuronal receptors and channels GRIA2 OPRM1 TRPC3 FKBP5 GRIN2B MET SLC2A3 PTPN4 PTPN1 CREB1 HDAC2 HDAC1 SIN3A OPRK1 GPRIN1 GRIN2A CONSTITUTIVE SIGNALING BY ABERRANT PI3K IN CANCER%REACTOME%R-HSA-2219530.1 Constitutive Signaling by Aberrant PI3K in Cancer KIT PDGFB VAV1 ESR2 STRN PIK3AP1 PTPN11 RAC2 RHOG FGF6 PIK3R2 FGF9 FGF20 FGF1 FGF2 FGF23 FGF3 FYN FGF22 FGF10 FGF4 HGF PIK3R3 MET KLB IRS1 IRS2 FGF19 FGFR4 CD86 TRAT1 LCK CD80 CD28 NRG1 NRG2 FRS2 NRG3 FGF16 FGF7 NRG4 PIK3CD FGF18 ESR1 PDGFRA EGF GAB1 PIK3R1 EGFR PIK3CA ERBB2 BTC EPGN TGFA AREG HBEGF EREG CD19 PIK3CB SRC RAC1 PDGFRB TGFBR1 KD MUTANTS IN CANCER%REACTOME%R-HSA-3656532.2 TGFBR1 KD Mutants in Cancer SMAD2 TGFB1 SMAD3 TGFBR1 TGFBR2 BIOLOGICAL OXIDATIONS%REACTOME DATABASE ID RELEASE 72%211859 Biological oxidations CYP3A43 ALDH1A1 UGP2 CYP1A2 CYP1A1 ALDH1B1 ACY3 ACY1 AS3MT CYP2D6 AHCY CYP8B1 CYP2E1 AOC3 AOC1 AOC2 FMO1 FMO2 AKR7A2 AKR7A3 FMO3 AHR ABHD10 SULT6B1 NNMT CYP2B6 CYB5R3 GLYAT AIP GLYATL3 GLYATL2 GLYATL1 CYP2C9 CYP2C8 NAT1 NAT2 CYP4F22 PODXL2 ESD CYP4A22 UGT3A2 TRMT112 UGT3A1 CYP4F11 CYP4F12 CYP4A11 PTGS1 ACSS2 CYP2F1 ACSS1 AADAC UGT1A10 ACSM5 ACSM4 HPGDS CHAC2 CHAC1 ADH7 CYP19A1 ADH5 ADH6 CMBL ADH4 CYP27A1 MAOB MAOA MGST3 GGCT MGST1 MGST2 HSP90AB1 MARC2 MARC1 ARNT GSTT2B CYP2A7 CYP2A6 AHRR PAPSS2 PAPSS1 GSS NR1H4 FDX1L CYB5B N6AMT1 TPMT ARNT2 NQO2 AKR7L GSTK1 SLC26A2 ALDH3A1 SLC26A1 EPHX1 SULT1A1 SULT1A4 SULT1A3 SULT1A2 GSTM4 GSTM3 UGT1A1 GSTM2 GSTM1 ALDH2 CYP4F2 CYP4F3 CYP4F8 SULT1B1 CYP4V2 GSTM5 PTGIS CYP3A4 CYP3A5 BPHL CYP3A7 UGT1A5 UGT1A4 SULT1C2 UGT1A3 UGT1A9 UGT1A8 UGT1A7 UGT1A6 SULT1C4 CYP51A1 GSTO2 BPNT1 GSTO1 NCOA1 POMC SLC35B3 SLC35B2 NCOA2 CYP21A2 MTRR AKR1A1 RXRA CYP2A13 GSTP1 SULT1E1 POR CYP2U1 CYP46A1 GGT1 SLC35D1 MAT1A DPEP2 DPEP1 DPEP3 UGT2B10 UGT2B11 UGT2B15 UGT2B17 TPST2 TPST1 CYP11A1 GGT5 CYP2S1 GSTT2 GGT7 GSTT1 GGT6 CYP2C19 CYP2C18 GCLC CYP11B2 CYP11B1 GCLM CYP7B1 ACSM2A UGDH MTR ADH1C ADH1B ADH1A SULT4A1 TBXAS1 ABHD14B CYP7A1 CYP26A1 CYP27B1 CYP26B1 CYP24A1 CYP26C1 CYP2R1 UGT2A3 CBR3 UGT2A2 PAOX UGT2A1 MAT2B PTGES3 CYP2W1 MAT2A IMPAD1 GSTA5 UGT2B4 ACSM1 GSTA4 GSTA3 ACSM2B GSTA2 GSTA1 UGT2B7 COMT CNDP2 UGT2B28 CYP4B1 FDXR GSTZ1 CYP1B1 CYP2J2 SULT2A1 CYP3A7-CYP3A51P CYP39A1 FDX1 CES3 CES2 CES1 OPLAH GAP JUNCTION ASSEMBLY%REACTOME DATABASE ID RELEASE 72%190861 Gap junction assembly GJA3 GJA5 GJA4 GJD2 GJA9 GJA8 GJC2 GJB4 GJB3 GJA1 GJB6 GJB2 GJB5 GJB1 GJB7 GJD4 GJD3 GJC1 GJA10 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI)%REACTOME%R-HSA-162710.3 Synthesis of glycosylphosphatidylinositol (GPI) PIGG PIGW PIGF PIGV PIGY PIGH PIGX PIGC DPM2 PIGB PIGA PIGO PIGN PIGM PIGP PIGL PIGZ RESISTANCE OF ERBB2 KD MUTANTS TO AFATINIB%REACTOME DATABASE ID RELEASE 72%9665249 Resistance of ERBB2 KD mutants to afatinib ERBB2IP HSP90AA1 CDC37 ERBB2 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE%REACTOME DATABASE ID RELEASE 72%166016 Toll Like Receptor 4 (TLR4) Cascade CUL1 ITGAM MAP2K1 ITGB2 DNM1 DNM3 CD180 PLCG2 BPI MAPK8 PPP2R1B PPP2R1A APP RELA PPP2R5D IRAK3 TIRAP TLR1 BIRC2 SIGIRR BIRC3 TLR6 TLR2 PTPN4 TRAF3 PPP2CA HMGB1 PPP2CB IKBKB NKIRAS1 NKIRAS2 MAP3K8 MAP2K3 CHUK MAP2K4 RIPK2 IRAK4 PELI1 UBE2V1 PELI3 PELI2 NFKB1 NOD1 NFKB2 NOD2 AGER MAPK9 IRAK1 S100A12 MAP2K7 MAP3K1 CD36 S100B MAPK10 TNIP2 JUN SAA1 MYD88 NFKBIB FBXW11 SOCS1 TANK ECSIT TICAM2 LY96 TICAM1 CD14 TLR4 MAPKAPK3 PTPN11 UBA52 ATF1 ATF2 NFKBIA IKBKG IKBKE ELK1 RPS6KA3 RPS6KA5 RPS6KA2 RPS6KA1 DUSP4 MEF2A MEF2C UBE2D1 DUSP3 FOS VRK3 UBB DUSP6 DNM2 UBC DUSP7 CREB1 MAPKAPK2 RPS27A IRF3 UBE2D2 MAPK7 UBE2D3 MAPK1 MAPK3 MAPK14 MAPK11 UBE2N CASP8 RIPK1 MAP2K6 FADD TBK1 RIPK3 IRF7 BTRC SKP1 BTK IRAK2 TRAF6 TAB3 TAB2 LY86 TAB1 MAP3K7 LBP ABACAVIR METABOLISM%REACTOME%R-HSA-2161541.3 Abacavir metabolism ADH1A ADAL PCK1 GUK1 NT5C2 DEFECTIVE SLC4A4 CAUSES RENAL TUBULAR ACIDOSIS, PROXIMAL, WITH OCULAR ABNORMALITIES AND MENTAL RETARDATION (PRTA-OA)%REACTOME%R-HSA-5619054.1 Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) SLC4A4 RESISTANCE OF ERBB2 KD MUTANTS TO TRASTUZUMAB%REACTOME%R-HSA-9665233.1 Resistance of ERBB2 KD mutants to trastuzumab ERBB2IP HSP90AA1 CDC37 ERBB2 INTERACTION BETWEEN PHLDA1 AND AURKA%REACTOME%R-HSA-8854521.2 Interaction between PHLDA1 and AURKA AURKA PHLDA1 DEFECTIVE EXT2 CAUSES EXOSTOSES 2%REACTOME%R-HSA-3656237.2 Defective EXT2 causes exostoses 2 SDC4 SDC2 SDC3 GPC1 GPC3 GPC2 GPC5 GPC4 GPC6 EXT1 HSPG2 EXT2 SDC1 AGRN ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%R-HSA-111447.2 Activation of BAD and translocation to mitochondria AKT1 YWHAG BAD YWHAZ BCL2 YWHAH YWHAB YWHAE AKT2 AKT3 SFN BID PPP3CC YWHAQ PPP3R1 PYRIMIDINE SALVAGE%REACTOME DATABASE ID RELEASE 72%73614 Pyrimidine salvage UPP2 CDA UPP1 UCKL1 HDHD1 DCK TK2 UCK2 TK1 TYMP UCK1 SPRY REGULATION OF FGF SIGNALING%REACTOME DATABASE ID RELEASE 72%1295596 Spry regulation of FGF signaling PPP2CA PPP2CB BRAF PTPN11 SPRY2 UBB UBC CBL RPS27A UBA52 PPP2R1A MKNK1 MAPK1 MAPK3 FOXO-MEDIATED TRANSCRIPTION OF CELL CYCLE GENES%REACTOME%R-HSA-9617828.1 FOXO-mediated transcription of cell cycle genes GADD45A CAV1 SMAD4 FOXO3 CDKN1A BTG1 CDKN1B MSTN KLF4 RBL2 SMAD2 SMAD3 PCBP4 FOXG1 FOXO1 FOXO4 CCNG2 EML4 AND NUDC IN MITOTIC SPINDLE FORMATION%REACTOME DATABASE ID RELEASE 72%9648025 EML4 and NUDC in mitotic spindle formation PPP2R5B PPP2R5A PPP1CC CLASP1 DYNC1H1 NDE1 NUP107 NEK9 PPP2R5C NEK6 NEK7 ERCC6L ZWILCH BUB1B CASC5 CDC20 PPP2R1B PPP2R1A KNTC1 EML4 DYNC1LI1 BIRC5 DYNC1LI2 CLIP1 RPS27 ZW10 MAD1L1 SEC13 CDCA8 NUP133 PMF1 SKA1 AURKB SKA2 DSN1 PPP2R5D RCC2 PLK1 NDC80 ZWINT KIF18A SGOL2 SGOL1 NUF2 SPDL1 NDEL1 NUDC DYNLL2 KIF2A INCENP KIF2C KIF2B ITGB3BP MIS12 CENPA NSL1 NUP160 CENPC PPP2CA BUB3 PPP2CB BUB1 NUP85 DYNC1I1 CLASP2 CENPT CENPU NUP43 CENPE APITD1 AHCTF1 CENPF RANGAP1 CENPH CENPI TAOK1 RANBP2 CENPK CENPL CENPM CENPN B9D2 CENPO CENPP CENPQ SPC24 MAD2L1 SPC25 NUP37 DYNLL1 CKAP5 MAPRE1 PAFAH1B1 XPO1 DYNC1I2 PPP2R5E DEFECTIVE CYP27B1 CAUSES RICKETS VITAMIN D-DEPENDENT 1A (VDDR1A)%REACTOME%R-HSA-5579014.2 Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A) CYP27B1 HCN CHANNELS%REACTOME%R-HSA-1296061.1 HCN channels HCN3 HCN2 HCN4 HCN1 PHOSPHOLIPASE C-MEDIATED CASCADE; FGFR3%REACTOME%R-HSA-5654227.2 Phospholipase C-mediated cascade; FGFR3 FGF9 PLCG1 FGF20 FGF16 FGF1 FGF2 FGF18 FGF23 FGF4 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME DATABASE ID RELEASE 72%427413 NoRC negatively regulates rRNA expression TAF1B TAF1C SAP30L TAF1A TWISTNB POLR2E POLR2F SAP18 POLR2H POLR2K POLR2L MBD2 GTF2H1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 ERCC3 ERCC2 CCNH ARID4B TTF1 SAP130 HIST1H2AE HIST1H2AD HIST3H2BB HIST1H2AC HIST1H2AB SAP30BP HIST1H2AJ CD3EAP SAP30 HIST2H3A HIST1H2BF HIST1H2BE HIST1H2BH HIST1H2BG HIST2H3D HIST1H2BB HIST1H2BA HIST2H3C HIST1H2BD HIST1H2BC H2AFB1 DNMT1 HIST1H3J BAZ2A HIST1H3A HIST1H3F HIST1H3G HIST1H3H HIST1H3I SUDS3 HIST1H3B HIST1H3C HIST1H3D HIST1H3E H3F3B HIST1H4K HIST1H4L H3F3A SMARCA5 H2BFS HIST1H4A CDK7 HIST1H4B HIST1H4H HIST1H4I HIST1H4J HIST1H4C MNAT1 HIST1H4D HIST1H4E HIST1H4F HIST2H2AA3 HIST2H2AA4 HIST2H2AC ZNRD1 SIN3B H2AFJ SIN3A UBTF DNMT3B TBP H2AFZ H2AFX H2AFV HIST2H2BE POLR1A HIST4H4 POLR1B POLR1C POLR1E HIST1H2BN HIST1H2BM HDAC2 HIST1H2BO HIST1H2BJ HDAC1 HIST1H2BI HIST1H2BL HIST1H2BK HIST2H4A TAF1D HIST2H4B ADORA2B MEDIATED ANTI-INFLAMMATORY CYTOKINES PRODUCTION%REACTOME DATABASE ID RELEASE 72%9660821 ADORA2B mediated anti-inflammatory cytokines production PRKAR2B PRKAR2A CYSLTR2 HTR6 HTR7 GNAS HTR4 ADCY4 VIPR1 ADCY3 VIPR2 PRKACG SCT ADCY2 RXFP1 PRKACA ADCY1 RXFP2 PRKACB ADCY8 ADCY7 ADCY6 GPR176 ADCY5 PTGDR LHCGR TAAR8 TAAR9 TAAR6 TAAR5 TAAR2 TAAR1 ADCYAP1 IAPP ADCYAP1R1 CALCA CALCRL CALCB GIPR GPR83 ADRB1 GPR84 ADRB2 CRHR1 CRHR2 GHRHR TSHB GCG MC2R CALCR HRH2 DRD1 DRD5 GPR15 AVP IL6 MC1R RLN2 RLN3 GPR27 GPR25 GPR20 ADM PTH1R MC4R INSL3 GPR39 FSHB GPR32 AVPR2 GLP2R POMC GPBAR1 PTH2R GIP MC3R ADORA2A ADRB3 ADORA2B FSHR CRH NPSR1 PTGER4 RAMP2 RAMP3 GPR45 PTH PTGER2 PRKX PTH2 PTHLH NPS GPR150 GPHA2 P2RY11 SCTR TSHR GHRH ADM2 MC5R VIP RAMP1 PTGIR GPHB5 LHB GNAT3 CREB1 GNAZ GNG10 GNG12 GNG11 GNG13 CGA GNB2 GNB1 GNB4 GNB3 GNB5 GNGT1 GNGT2 GNAI3 GNAI1 GNAI2 GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 ADCY9 GLP1R PRKAR1B PRKAR1A DNA DOUBLE-STRAND BREAK REPAIR%REACTOME%R-HSA-5693532.3 DNA Double-Strand Break Repair EXO1 WHSC1 POLK RPA1 POLE RPA2 POLH POLD3 TOPBP1 RFC1 POLD4 WRN RPA3 POLD1 POLD2 DNA2 RFC5 SPIDR RFC3 RFC4 RFC2 RNF8 RNF4 CCNA2 CCNA1 MAPK8 POLQ KDM4A KDM4B EYA1 POLM EYA2 EYA3 EYA4 RAD52 POLE4 RAD51 RBBP8 BRE ERCC4 ERCC1 POLE2 HIST3H3 POLE3 MDC1 KAT5 RAD50 CHEK2 CHEK1 HUS1 TP53 RHNO1 BRIP1 ATRIP BARD1 RAD17 ATM UBE2I ATR BRCA1 SUMO1 SUMO2 HERC2 PPP4R2 RTEL1 TIPIN RMI2 RMI1 TOP3A RAD51D PIAS4 PAXIP1 PRKDC UBA52 BRCC3 PPP4C TP53BP1 HIST3H2BB NHEJ1 XRCC6 XRCC4 XRCC5 XRCC2 XRCC3 MRE11A XRCC1 HIST1H2BF HIST1H2BE PPP5C HIST1H2BH HIST1H2BG TDP2 TDP1 HIST1H2BB HIST1H2BA BAP1 HIST1H2BD HIST1H2BC BRCA2 UBB RAD1 BABAM1 UIMC1 UBC PARP1 PARP2 KPNA2 SIRT6 RPS27A RAD51B RNF168 RAD51C NBN HIST1H4K HIST1H4L SMARCA5 SLX4 H2BFS HIST1H4A APBB1 HIST1H4B HIST1H4H HIST1H4I HIST1H4J HIST1H4C HIST1H4D HIST1H4E DCLRE1C UBE2N RIF1 HIST1H4F EME1 EME2 GEN1 SLX1B LIG4 LIG3 TIMELESS UBE2V2 SLX1A H2AFX BAZ1B RAD51AP1 ABL1 HIST2H2BE CLSPN HIST4H4 CDK2 PALB2 HIST1H2BN HIST1H2BM RAD9B HIST1H2BO RAD9A HIST1H2BJ FAM175A HIST1H2BI HIST1H2BL HIST1H2BK MUS81 HIST2H4A FEN1 BLM HIST2H4B POLL PCNA SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21%REACTOME DATABASE ID RELEASE 72%187577 SCF(Skp2)-mediated degradation of p27 p21 PSMD3 CUL1 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME1 PSME2 CCNA2 CCNA1 UBA52 PSMD10 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 UBB PSMB3 CCND1 UBC PSMB1 PSMF1 RPS27A SHFM1 PSMB8 PSMB9 SKP2 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 CCNE2 CCNE1 CKS1B PTK6 CDK4 CDK2 CDKN1A CDKN1B SKP1 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 HEDGEHOG LIGAND BIOGENESIS%REACTOME DATABASE ID RELEASE 72%5358346 Hedgehog ligand biogenesis PSMD3 OS9 PSMD1 PSMA5 PSMA6 PSMA3 SYVN1 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 UBA52 PSMD10 DISP2 PSMB11 PSMD12 HHAT SCUBE2 SHH PSMD11 PSMD14 DHH IHH PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 NOTUM PSMB7 PSMB4 PSMB5 PSMB2 ADAM17 UBB PSMB3 UBC PSMB1 PSMF1 RPS27A SHFM1 PSMB8 PSMB9 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 ERLEC1 GPC5 P4HB PSMD8 VCP PSMD9 PSMD6 PSMD7 SEL1L PSMD4 PSMD5 DERL2 PSMD2 APOBEC3G MEDIATED RESISTANCE TO HIV-1 INFECTION%REACTOME%R-HSA-180689.1 APOBEC3G mediated resistance to HIV-1 infection PSIP1 BANF1 HMGA1 PPIA FASL CD95L SIGNALING%REACTOME DATABASE ID RELEASE 72%75157 FasL CD95L signaling FAS CASP10 FASLG FADD CASP8 DEFECTIVE SLC35A3 CAUSES ARTHROGRYPOSIS, MENTAL RETARDATION, AND SEIZURES (AMRS)%REACTOME%R-HSA-5619083.1 Defective SLC35A3 causes arthrogryposis, mental retardation, and seizures (AMRS) SLC35A3 BIOSYNTHESIS OF DPA-DERIVED SPMS%REACTOME DATABASE ID RELEASE 72%9018683 Biosynthesis of DPA-derived SPMs PTGS2 ALOX15 ALOX12 ALOX5 DEFECTIVE DPAGT1 CAUSES DPAGT1-CDG (CDG-1J) AND CMSTA2%REACTOME%R-HSA-4549356.1 Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2 DPAGT1 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%R-HSA-5250941.2 Negative epigenetic regulation of rRNA expression TAF1B TAF1C SAP30L TAF1A TWISTNB POLR2E POLR2F SAP18 POLR2H POLR2K POLR2L MBD2 GTF2H1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 ERCC3 ERCC2 CCNH ARID4B TTF1 RRP8 SAP130 HIST1H2AE HIST1H2AD HIST3H2BB HIST1H2AC HIST1H2AB SAP30BP HIST1H2AJ CD3EAP SAP30 HIST2H3A HIST1H2BF HIST1H2BE HIST1H2BH HIST1H2BG HIST2H3D HIST1H2BB HIST1H2BA HIST2H3C HIST1H2BD HIST1H2BC H2AFB1 DNMT1 HIST1H3J BAZ2A HIST1H3A HIST1H3F HIST1H3G HIST1H3H HIST1H3I SUDS3 HIST1H3B HIST1H3C HIST1H3D HIST1H3E H3F3B HIST1H4K HIST1H4L H3F3A SMARCA5 H2BFS HIST1H4A CDK7 HIST1H4B HIST1H4H HIST1H4I HIST1H4J HIST1H4C MNAT1 HIST1H4D HIST1H4E HIST1H4F HIST2H2AA3 HIST2H2AA4 SUV39H1 HIST2H2AC ZNRD1 SIN3B H2AFJ SIN3A UBTF DNMT3B TBP H2AFZ H2AFX H2AFV SIRT1 HIST2H2BE POLR1A HIST4H4 POLR1B POLR1C POLR1E HIST1H2BN HIST1H2BM HDAC2 HIST1H2BO HIST1H2BJ HDAC1 HIST1H2BI HIST1H2BL HIST1H2BK HIST2H4A TAF1D HIST2H4B REGULATION OF LOCALIZATION OF FOXO TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 72%9614399 Regulation of localization of FOXO transcription factors AKT1 YWHAB FOXO3 AKT2 YWHAG AKT3 SFN YWHAZ FOXO1 YWHAQ FOXO6 FOXO4 NUCLEAR SIGNALING BY ERBB4%REACTOME%R-HSA-1251985.5 Nuclear signaling by ERBB4 NCSTN APH1B NRG1 NRG2 NRG3 APOE NRG4 WWOX ESR1 PSENEN S100B SPARC NCOR1 STMN1 YAP1 STAT5A BTC ADAP1 GFAP ADAM17 CSN2 HBEGF EREG MXD4 PGR SRC PSEN2 TAB2 PSEN1 CXCL12 APH1A RESISTANCE OF ERBB2 KD MUTANTS TO SAPITINIB%REACTOME%R-HSA-9665244.1 Resistance of ERBB2 KD mutants to sapitinib ERBB2IP HSP90AA1 CDC37 ERBB2 RUNX3 REGULATES IMMUNE RESPONSE AND CELL MIGRATION%REACTOME%R-HSA-8949275.1 RUNX3 Regulates Immune Response and Cell Migration ITGAL RUNX3 ITGA4 CBFB SPP1 ACTIVATION OF NA-PERMEABLE KAINATE RECEPTORS%REACTOME%R-HSA-451307.2 Activation of Na-permeable kainate receptors GRIK1 GRIK2 BUTYROPHILIN (BTN) FAMILY INTERACTIONS%REACTOME DATABASE ID RELEASE 72%8851680 Butyrophilin (BTN) family interactions BTNL8 BTNL2 BTN2A2 CD209 BTN2A1 PPL XDH BTN3A1 BTN3A3 BTN3A2 BTN1A1 BTNL9 EPH-EPHRIN MEDIATED REPULSION OF CELLS%REACTOME%R-HSA-3928665.3 EPH-ephrin mediated repulsion of cells NCSTN EPHA5 ADAM10 APH1B LYN EPHA4 EPHA7 EPHA6 DNM1 VAV2 YES1 EPHA8 EPHA3 EPHA1 EPHA2 EPHA10 PSENEN TIAM1 FYN EFNA5 EFNA4 EFNA1 EFNA3 EFNA2 EFNB2 EFNB1 EFNB3 EPHB2 EPHB1 EPHB4 EPHB3 CLTC CLTB CLTA AP2A1 AP2B1 AP2A2 CLTCL1 AP2S1 AP2M1 PSEN2 PSEN1 MMP9 RAC1 APH1A VAV3 MMP2 TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 72%379724 tRNA Aminoacylation HARS IARS FARSA EEF1E1 FARSB AARS PARS2 EARS2 LARS2 TARS2 AARS2 HARS2 FARS2 CARS YARS DARS WARS VARS YARS2 NARS2 SARS TARS RARS2 EPRS CARS2 VARS2 AIMP1 NARS MARS2 DARS2 AIMP2 SARS2 KARS QARS LARS PPA2 PPA1 RARS IARS2 WARS2 MARS GARS CHREBP ACTIVATES METABOLIC GENE EXPRESSION%REACTOME%R-HSA-163765.2 ChREBP activates metabolic gene expression ACACA MLXIPL MLX ACLY FASN AGPAT1 ACACB SODIUM-COUPLED PHOSPHATE COTRANSPORTERS%REACTOME DATABASE ID RELEASE 72%427652 Sodium-coupled phosphate cotransporters SLC34A3 SLC34A2 SLC34A1 SLC20A2 SLC20A1 TYPE I HEMIDESMOSOME ASSEMBLY%REACTOME DATABASE ID RELEASE 72%446107 Type I hemidesmosome assembly DST LAMC2 COL17A1 ITGB4 LAMA3 PLEC LAMB3 CD151 ITGA6 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE%REACTOME%R-HSA-210500.3 Glutamate Neurotransmitter Release Cycle SLC1A2 SLC1A3 SLC1A6 SLC1A7 CPLX1 SLC38A2 RIMS1 BZRAP1 PPFIA1 PPFIA4 STX1A VAMP2 PPFIA3 ARL6IP5 PPFIA2 GLS UNC13B SLC17A7 SNAP25 SLC1A1 RAB3A SYT1 GLS2 VEGFR2 MEDIATED VASCULAR PERMEABILITY%REACTOME DATABASE ID RELEASE 72%5218920 VEGFR2 mediated vascular permeability PDPK1 AKT1 VAV1 VAV2 TRIB3 MAPKAP1 PAK1 CTNNA1 HSP90AA1 RICTOR PAK3 PAK2 JUP NOS3 CAV1 MTOR PRR5 CTNNB1 THEM4 CTNND1 CDH5 AKT2 AKT3 MLST8 RAC1 VAV3 GAP JUNCTION TRAFFICKING AND REGULATION%REACTOME DATABASE ID RELEASE 72%157858 Gap junction trafficking and regulation DNM1 MYO6 GJD2 GJA1 GJB2 GJB1 GJC1 GJA10 GJA3 GJA5 TJP1 GJA4 GJA9 GJA8 GJC2 CLTC DNM2 GJB4 CLTB GJB3 CLTA GJB6 GJB5 GJB7 CLTCL1 GJD4 GJD3 AP2M1 DAB2 TRANSLESION SYNTHESIS BY POLH%REACTOME%R-HSA-110320.1 Translesion Synthesis by POLH RPA1 RPA2 NPLOC4 POLH RFC1 RPA3 SPRTN RFC5 RFC3 RFC4 UBB RFC2 UBC RCHY1 RPS27A UBA52 VCP UFD1L PCNA NEGATIVE REGULATION OF ACTIVITY OF TFAP2 (AP-2) FAMILY TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 72%8866904 Negative regulation of activity of TFAP2 (AP-2) family transcription factors TFAP2A TFAP2C KCTD15 UBE2I WWOX TFAP2D KCTD1 TFAP2B SUMO1 TFAP2E PHENYLALANINE AND TYROSINE METABOLISM%REACTOME%R-HSA-8963691.1 Phenylalanine and tyrosine metabolism ASRGL1 HPD TAT QDPR GSTZ1 IL4I1 PCBD1 FAH HGD PAH CCBL1 BUDDING AND MATURATION OF HIV VIRION%REACTOME%R-HSA-162588.1 Budding and maturation of HIV virion TSG101 VPS4B VPS4A MVB12B MVB12A VTA1 VPS37C VPS37D CHMP2A PPIA VPS37A PDCD6IP NEDD4L VPS37B CHMP2B CHMP4C UBAP1 CHMP4B UBA52 CHMP3 CHMP4A CHMP6 CHMP7 VPS28 CHMP5 UBB UBC RPS27A INTEGRIN SIGNALING%REACTOME%R-HSA-354192.2 Integrin signaling PDPK1 AKT1 CRK ITGA2B SHC1 PTPN1 RASGRP2 SYK APBB1IP SOS1 RASGRP1 RAP1B FGB FGA FN1 VWF PTK2 RAP1A FGG RAPGEF3 BCAR1 ITGB3 RAPGEF4 SRC CSK TLN1 LDL REMODELING%REACTOME%R-HSA-8964041.1 LDL remodeling LPA CETP APOF APOB DNA REPLICATION PRE-INITIATION%REACTOME DATABASE ID RELEASE 72%69002 DNA Replication Pre-Initiation PSMD3 RPA1 PSMD1 POLE RPA2 RPA3 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 UBA52 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 POLE4 PSMB7 E2F1 PSMB4 PSMB5 PSMB2 POLE2 UBB PSMB3 POLE3 UBC PSMB1 PSMF1 RPS27A SHFM1 GMNN PSMB8 PSMB9 PSMC5 PSMC6 PSMC3 ORC5 PSMC4 ORC4 PSMC1 ORC6 PSMC2 ORC1 ORC3 ORC2 E2F2 CDT1 E2F3 CDC7 CDC6 POLA1 POLA2 MCM7 MCM8 MCM10 DBF4 MCM3 MCM4 MCM5 MCM6 MCM2 PRIM2 PRIM1 CDC45 RPA4 CDK2 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 DOWNSTREAM SIGNALING OF ACTIVATED FGFR1%REACTOME DATABASE ID RELEASE 72%5654687 Downstream signaling of activated FGFR1 HRAS FLRT3 FRS2 PTPN11 FRS3 FLRT2 FLRT1 NRAS GAB1 PIK3R1 FGF6 PIK3CA FGF9 PLCG1 SOS1 FGF20 FGF1 FGF2 FGF23 FGF3 FGF22 FGF10 FGF4 SYNTHESIS OF BILE ACIDS AND BILE SALTS%REACTOME%R-HSA-192105.2 Synthesis of bile acids and bile salts PTGIS ACOX2 CYP46A1 HSD3B7 CH25H OSBPL9 NCOA1 SLC27A2 SLC27A5 OSBPL7 NCOA2 OSBPL6 OSBPL3 OSBPL2 AKR1D1 RXRA BAAT CYP7B1 HSD17B4 OSBP ACOT8 AKR1C1 AMACR AKR1C3 ABCB11 AKR1C2 NR1H4 CYP7A1 CYP39A1 AKR1C4 CYP8B1 OSBPL1A CYP27A1 REVERSE TRANSCRIPTION OF HIV RNA%REACTOME DATABASE ID RELEASE 72%162589 Reverse Transcription of HIV RNA PPIA FGFR4 MUTANT RECEPTOR ACTIVATION%REACTOME%R-HSA-1839128.1 FGFR4 mutant receptor activation FGFR4 INTERLEUKIN-23 SIGNALING%REACTOME%R-HSA-9020933.1 Interleukin-23 signaling P4HB JAK2 STAT4 STAT3 IL12RB1 IL23R IL12B IL23A TYK2 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 72%2644602 Signaling by NOTCH1 PEST Domain Mutants in Cancer CUL1 NCSTN ADAM10 APH1B TBL1X CCNC UBA52 PSENEN TBL1XR1 EP300 ADAM17 UBB UBC RPS27A MYC NOTCH1 MAML2 MAML1 RBPJ HES1 SNW1 MAML3 MAMLD1 NCOR2 CREBBP HDAC11 HEY1 NCOR1 HDAC3 HEY2 HDAC4 HDAC5 DLL1 HDAC10 HDAC9 KAT2B HDAC6 KAT2A HDAC7 DLL4 NEURL1B HES5 JAG2 JAG1 MIB2 MIB1 HDAC8 HEYL NEURL1 HDAC2 SKP1 HDAC1 RBX1 PSEN2 PSEN1 APH1A CDK8 EXTRINSIC PATHWAY OF FIBRIN CLOT FORMATION%REACTOME%R-HSA-140834.2 Extrinsic Pathway of Fibrin Clot Formation F7 F9 F10 TFPI F3 DEFECTIVE BASE EXCISION REPAIR ASSOCIATED WITH NEIL3%REACTOME%R-HSA-9629232.2 Defective Base Excision Repair Associated with NEIL3 NEIL3 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 72%110373 Resolution of AP sites via the multiple-nucleotide patch replacement pathway LIG1 RPA1 POLE RPA2 POLD3 POLD4 RFC1 RPA3 POLD1 APEX1 POLD2 RFC5 RFC3 RFC4 PARG RFC2 ADPRHL2 POLE4 POLE2 POLE3 PARP1 PARP2 FEN1 POLB PCNA NOTCH4 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME DATABASE ID RELEASE 72%9013695 NOTCH4 Intracellular Domain Regulates Transcription MAML2 HEY1 MAML1 HEY2 EP300 RBPJ KAT2B HES1 KAT2A HES5 FLT4 SNW1 MAML3 SMAD3 MAMLD1 ACTA2 NOTCH2 NOTCH4 CREBBP NOTCH1 ESTABLISHMENT OF SISTER CHROMATID COHESION%REACTOME DATABASE ID RELEASE 72%2468052 Establishment of Sister Chromatid Cohesion WAPAL PDS5B PDS5A SMC1A SMC3 RAD21 STAG1 ESCO1 ESCO2 STAG2 CDCA5 P75 NTR RECEPTOR-MEDIATED SIGNALLING%REACTOME%R-HSA-193704.1 p75 NTR receptor-mediated signalling NCSTN CASP2 BCL2L11 APH1B VAV1 VAV2 ECT2 ARHGEF33 ARHGEF35 ARHGEF37 ARHGEF7 ARHGEF39 ARHGEF38 NET1 RASGRF2 ARHGEF10L AATF AKAP13 CASP3 UBA52 MCF2L MAPK8 PSENEN ARHGEF11 TIAM1 ARHGEF10 ARHGEF12 PLEKHG2 ARHGEF15 NFKBIA ARHGEF17 PLEKHG5 ARHGEF16 RELA ARHGEF19 ARHGEF9 ARHGEF3 ARHGEF4 ARHGEF1 ARHGEF2 SOS2 ARHGEF5 NGFR ARHGDIA ADAM17 UBB FGD1 FGD2 FGD3 UBC GNA13 FGD4 LINGO1 RPS27A MCF2 ITGB3BP IKBKB BAD RIPK2 SMPD2 NFKB1 IRAK1 SOS1 MYD88 HDAC3 TRIO ARHGEF18 PRDM4 ITSN1 RHOA PREX1 ARHGEF40 PRKCI OMG MAG OBSCN HDAC2 NGFRAP1 YWHAE NGEF HDAC1 TRAF6 ARHGEF6 ARHGEF26 MAGED1 SQSTM1 PSEN2 PSEN1 RAC1 KALRN TIAM2 RTN4 VAV3 NGF APH1A ABR PROCESSING AND ACTIVATION OF SUMO%REACTOME%R-HSA-3215018.2 Processing and activation of SUMO SUMO2 UBA2 RWDD3 SAE1 SENP5 SENP2 SENP1 UBE2I SUMO1 SUMO3 TP53 REGULATES METABOLIC GENES%REACTOME%R-HSA-5628897.4 TP53 Regulates Metabolic Genes AKT1 COX8A YWHAG YWHAZ YWHAH GPX2 GPI COX5B COX5A RRM2B PRKAA1 TIGAR PRKAA2 GLS2 COX6C LRPPRC MTOR LAMTOR2 LAMTOR1 LAMTOR4 NDUFA4 LAMTOR3 LAMTOR5 TXNRD1 MT-CO1 TACO1 GLS COX6A1 TNRC6C SESN3 SESN2 G6PD TP63 PRKAB2 TSC2 PRKAB1 TNRC6A TSC1 RRAGA TNRC6B COX7A2L COX6B1 SCO1 RRAGC SCO2 RRAGB DDIT4 RRAGD MT-CO2 MT-CO3 COX16 TP53 COX18 TXN COX11 PRDX2 COX14 SLC38A9 PRDX1 SFN SURF1 MOV10 AGO3 AGO4 AGO1 RHEB AGO2 CYCS COX7B YWHAB COX20 YWHAE AKT2 PRKAG1 AKT3 MLST8 COX4I1 PRKAG2 PTEN COX7C PRKAG3 YWHAQ RPTOR CLASS I PEROXISOMAL MEMBRANE PROTEIN IMPORT%REACTOME DATABASE ID RELEASE 72%9603798 Class I peroxisomal membrane protein import PEX26 ABCD2 ABCD3 PEX11B FIS1 PXMP4 PEX3 PEX19 ATAD1 PEX12 PXMP2 PEX16 PEX13 PEX14 GDAP1 SLC25A17 ABCD1 PEX2 ACBD5 PRE-NOTCH TRANSCRIPTION AND TRANSLATION%REACTOME DATABASE ID RELEASE 72%1912408 Pre-NOTCH Transcription and Translation RUNX1 TFDP1 HIST1H2AE TFDP2 HIST1H2AD HIST3H2BB HIST1H2AC HIST1H2AB HIST1H2AJ HIST2H3A HIST1H2BF HIST1H2BE HIST1H2BH EP300 HIST1H2BG HIST2H3D HIST1H2BB E2F1 HIST1H2BA HIST2H3C HIST1H2BD HIST1H2BC H2AFB1 HIST1H3J CCND1 HIST1H3A HIST1H3F HIST1H3G HIST1H3H SIRT6 HIST1H3I HIST1H3B HIST1H3C TNRC6C HIST1H3D HIST1H3E H3F3B HIST1H4K HIST1H4L H3F3A NOTCH1 H2BFS MAML2 HIST1H4A TNRC6A MAML1 HIST1H4B TNRC6B HIST1H4H HIST1H4I RBPJ HIST1H4J E2F3 HIST1H4C HIST1H4D HIST1H4E TP53 HIST1H4F HIST2H2AA3 HIST2H2AA4 SNW1 ELF3 MAML3 HIST2H2AC MAMLD1 H2AFJ NOTCH2 NOTCH3 JUN NOTCH4 H2AFZ CREBBP H2AFX H2AFV MOV10 AGO3 HIST2H2BE AGO4 KAT2B AGO1 KAT2A AGO2 HIST4H4 PRKCI HIST1H2BN HIST1H2BM HIST1H2BO HIST1H2BJ HIST1H2BI HIST1H2BL HIST1H2BK HIST2H4A HIST2H4B GABA SYNTHESIS%REACTOME DATABASE ID RELEASE 72%888568 GABA synthesis GAD1 GAD2 MICRORNA (MIRNA) BIOGENESIS%REACTOME DATABASE ID RELEASE 72%203927 MicroRNA (miRNA) biogenesis XPO5 POLR2A PRKRA POLR2B POLR2C AGO3 POLR2D AGO4 POLR2G AGO1 POLR2E DGCR8 AGO2 POLR2F POLR2H POLR2I POLR2J POLR2K POLR2L DICER1 TARBP2 BCDIN3D RAN DROSHA CD28 CO-STIMULATION%REACTOME%R-HSA-389356.1 CD28 co-stimulation CD80 PDPK1 AKT1 CD28 LYN VAV1 MAP3K8 YES1 TRIB3 MAPKAP1 PIK3R1 PIK3R2 PIK3CA CDC42 PAK1 MAP3K14 RICTOR FYN PAK3 PAK2 MTOR PIK3R3 PRR5 THEM4 AKT2 AKT3 MLST8 GRAP2 RAC1 CD86 LCK FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS%REACTOME%R-HSA-2029480.1 Fcgamma receptor (FCGR) dependent phagocytosis VAV1 WIPF1 CFL1 PRKCD VAV2 WIPF2 FGR PPAPDC1A WIPF3 ELMO1 PPAPDC1B NF2 ELMO2 PLCG2 CRK DOCK1 LIMK1 ARPC1B ARPC1A WAS ITPR1 ITPR2 MYO9B ACTG1 ITPR3 ACTB PIK3R2 NCKIPSD CDC42 PAK1 ARPC4 NCKAP1L ARPC5 FYN ARPC2 IGHG4 WASF1 ARPC3 WASF2 IGHG1 ACTR3 IGHG2 ACTR2 WASF3 IGKV1-12 MYH2 MYO10 MYO1C BAIAP2 PTK2 ABI2 ABI1 IGKV2D-28 IGKV4-1 IGKV2D-30 PLD4 PLD1 PLA2G6 PLD3 PLD2 MAPK1 MAPK3 IGKV3-11 LYN YES1 HSP90AB1 MYO5A WASL CD3G FCGR3A PIK3R1 IGKV2-28 PIK3CA PLCG1 SYK HSP90AA1 IGKV3D-20 HCK ABL1 MYH9 CYFIP2 CYFIP1 NCKAP1 AHCYL1 BRK1 PIK3CB FCGR1A PRKCE BTK IGKV5-2 FCGR2A RAC1 NCK1 VAV3 METALLOTHIONEINS BIND METALS%REACTOME%R-HSA-5661231.2 Metallothioneins bind metals MT1M MT1X MT4 MT2A MT3 MT1A MT1F MT1G MT1H MT1B MT1E NEGATIVE REGULATION OF TCF-DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS%REACTOME%R-HSA-3772470.2 Negative regulation of TCF-dependent signaling by WNT ligand antagonists DKK1 WNT4 DKK2 DKK4 WNT5A SFRP1 SFRP2 SOST KREMEN1 WNT3A KREMEN2 WNT9A LRP5 WIF1 LRP6 MITOTIC G2-G2 M PHASES%REACTOME DATABASE ID RELEASE 72%453274 Mitotic G2-G2 M phases RBBP4 CUL1 PRKAR2B GTSE1 FKBPL YWHAG OFD1 CCNA2 CCNA1 PPP2R1B PPP2R1A HMMR PRKACA AURKA E2F1 PPP2CA PPP2CB CDC25B E2F3 CENPF TP53 CEP57 CETN2 CEP164 CCP110 PPP1CB ACTR1A PCM1 CNTRL CEP250 NEK2 NINL CEP290 RAB8A CDK5RAP2 CEP135 BORA TPX2 PPP1R12A FBXW11 PPME1 TUBB PHLDA1 CEP131 TUBGCP2 HAUS4 TUBGCP5 HAUS3 TUBGCP6 HAUS6 CSNK1D TUBGCP3 TUBGCP4 HAUS5 CSNK1E FBXL7 TUBG2 TUBG1 DYNLL1 MZT2B CDKN1A CKAP5 MZT2A HAUS2 NME7 HAUS1 LCMT1 AKAP9 CDK11A CEP63 FBXL18 MAPRE1 MZT1 AJUBA SFI1 PSMD8 OPTN PSMD9 PAFAH1B1 PSMD6 SDCCAG8 XPO1 DYNC1I2 PSMD7 DCTN2 PSMD4 SSNA1 PSMD5 DCTN3 PSMD2 CCNB2 HAUS8 PSMD3 HAUS7 CEP70 PSMD1 CEP72 CEP192 PCNT CEP76 CLASP1 CEP78 PLK4 PSMA5 PSMA6 DYNC1H1 ODF2 PSMA3 PSMA4 CEP152 PSMA1 NDE1 NEDD1 FGFR1OP PSMA2 PSME3 CEP41 CCNH PSME4 PSME1 PSME2 UBA52 PSMD10 PSMB11 PSMD12 PPP2R2A PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 EP300 PSMB6 PSMB7 PLK1 PSMB4 CENPJ PSMB5 PSMB2 CCNB1 UBB PSMB3 UBC CDK1 PSMB1 PSMF1 RPS27A TUBA4A SHFM1 PSMB8 PSMB9 PSMC5 CDC25A PSMC6 PSMC3 PSMC4 PSMC1 CDK7 PSMC2 CDC25C MNAT1 HSP90AB1 LIN54 LIN52 PKMYT1 FOXM1 TUBA1A MYBL2 LIN37 HSP90AA1 LIN9 PPP2R3B WEE1 CDK2 BTRC SKP1 YWHAE TUBB4B TUBB4A RBX1 POLYMERASE SWITCHING%REACTOME DATABASE ID RELEASE 72%69091 Polymerase switching POLD3 RFC1 POLD4 POLD1 POLA1 POLD2 RFC5 POLA2 RFC3 RFC4 RFC2 PRIM2 PRIM1 PCNA PI-3K CASCADE:FGFR4%REACTOME DATABASE ID RELEASE 72%5654720 PI-3K cascade:FGFR4 FRS2 PTPN11 FGF16 KLB FGF18 GAB1 PIK3R1 FGF19 FGFR4 FGF6 PIK3CA FGF9 FGF20 FGF1 FGF2 FGF23 FGF4 COPII-MEDIATED VESICLE TRANSPORT%REACTOME%R-HSA-204005.4 COPII-mediated vesicle transport CNIH3 MCFD2 RAB1B SEC24B PPP6C PPP6R1 SEC24A PPP6R3 TRAPPC6A TRAPPC6B GORASP1 SEC22A SEC22C FOLR1 BET1 NSF SEC24D SEC24C CTSZ SEC13 SAR1B COL7A1 NAPA F5 F8 CTSC NAPB NAPG SEC31A GOLGA2 TRAPPC4 SERPINA1 STX5 YKT6 TMED10 TFG LMAN1L GOSR2 LMAN2L SCFD1 TMED2 SEC23A STX17 USO1 LMAN1 CSNK1D LMAN2 TGFA AREG TRAPPC10 SEC23IP TRAPPC2L TBC1D20 CD59 TRAPPC2 ANKRD28 TRAPPC3 SEC16B SEC22B SEC16A PREB TRAPPC5 TRAPPC9 TRAPPC1 CNIH1 GRIA1 RAB1A CNIH2 SIGNALING BY EGFR IN CANCER%REACTOME%R-HSA-1643713.1 Signaling by EGFR in Cancer HRAS BTC EPGN TGFA AREG NRAS UBB HBEGF EREG EGF SHC1 UBC GAB1 PIK3R1 CBL EGFR RPS27A UBA52 PIK3CA PLCG1 SOS1 HSP90AA1 CDC37 DEFECTIVE SLC29A3 CAUSES HISTIOCYTOSIS-LYMPHADENOPATHY PLUS SYNDROME (HLAS)%REACTOME%R-HSA-5619063.2 Defective SLC29A3 causes histiocytosis-lymphadenopathy plus syndrome (HLAS) SLC29A3 SIGNALING BY FGFR2 FUSIONS%REACTOME%R-HSA-8853333.1 Signaling by FGFR2 fusions FGFR2 DARPP-32 EVENTS%REACTOME%R-HSA-180024.3 DARPP-32 events PPP2CA PPP2CB PRKAR2B PDE4B PRKAR2A PPP3CA PPP2R5D PPP3CB CDK5 PDE4A PDE4D PDE4C PPP2R1B PPP2R1A PRKACG PRKACA PPP3CC PRKAR1B PRKACB PPP1CA PRKAR1A PPP3R1 PPP1R1B DEREGULATED CDK5 TRIGGERS MULTIPLE NEURODEGENERATIVE PATHWAYS IN ALZHEIMER'S DISEASE MODELS%REACTOME DATABASE ID RELEASE 72%8862803 Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models CAST BCL2L11 CDC25C CDC25B LMNB1 FOXO3 GOLGA2 CAPNS1 CAPNS2 CDK5 CAPN2 CAPN1 CDK5R1 PRDX2 SOD2 FASLG PRDX1 YWHAE APP JUN CDC25A ACTIVATION OF BIM AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%R-HSA-111446.2 Activation of BIM and translocation to mitochondria BCL2L11 MAPK8 DYNLL1 SIGNALING BY PDGFR IN DISEASE%REACTOME DATABASE ID RELEASE 72%9671555 Signaling by PDGFR in disease KANK1 HRAS STAT1 GOLGA4 STRN ETV6 WDR48 NRAS PDGFRA PIK3R1 PIK3CB PIK3R2 PIK3CA STAT3 SOS1 KDR FIP1L1 APOPTOSIS%REACTOME%R-HSA-109581.3 Apoptosis BCL2L11 CDH1 YWHAG YWHAH APAF1 KPNA1 CASP3 TFDP1 MAPK8 TFDP2 E2F1 BIRC2 XIAP DYNLL2 BAX AVEN PPP3CC TP63 DIABLO UACA PPP3R1 BMF HMGB1 BAK1 CARD8 GZMB NMT1 LMNB1 BCL2L1 BCL2 BAD CASP9 DBNL TP53 TP53BP2 SFN UNC5A DAPK1 UNC5B DAPK2 DAPK3 OMA1 OPA1 APPL1 TP73 DYNLL1 DCC YWHAB AKT2 PSMD8 AKT3 PSMD9 PSMD6 TICAM2 LY96 PSMD7 TICAM1 PSMD4 CD14 PSMD5 BBC3 TLR4 PSMD2 PSMD3 AKT1 PSMD1 PRKCD YWHAZ PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 ROCK1 PSMA2 PSME3 PSME4 PSME1 PSME2 HMGB2 CASP7 ARHGAP10 FNTA UBA52 HIST1H1D PSMD10 HIST1H1E DNM1L PSMB11 PSMD12 SPTAN1 HIST1H1A PSMD11 HIST1H1B BID PSMD14 HIST1H1C DSP PSMD13 DFFB C1QBP DFFA CDKN2A APC GAS2 PSMA7 DSG1 PSMB10 PAK2 PKP1 PSMA8 PRKCQ DSG2 MAPT PSMB6 DSG3 PLEC PSMB7 PTK2 SATB1 PSMB4 BCAP31 GSN PSMB5 TJP1 OCLN PSMB2 UBB H1F0 STK24 PSMB3 CTNNB1 STK26 ACIN1 UBC VIM PSMB1 TJP2 PSMF1 BMX RPS27A KPNB1 SHFM1 PSMB8 PSMB9 MAPK1 PSMC5 PSMC6 MAPK3 PSMC3 PSMC4 APIP PSMC1 PSMC2 CASP8 TRADD TNFSF10 PMAIP1 FAS TNFRSF10B FASLG RIPK1 TNFRSF10A TRAF2 FADD ADD1 CLSPN CYCS YWHAE STAT3 PPP1R13B MAGED1 YWHAQ CASP6 VASOPRESSIN-LIKE RECEPTORS%REACTOME DATABASE ID RELEASE 72%388479 Vasopressin-like receptors OXTR AVP AVPR2 OXT AVPR1B AVPR1A TRANSPORT OF HA TRIMER, NA TETRAMER AND M2 TETRAMER FROM THE ENDOPLASMIC RETICULUM TO THE GOLGI APPARATUS%REACTOME%R-HSA-168874.3 Transport of HA trimer, NA tetramer and M2 tetramer from the endoplasmic reticulum to the Golgi Apparatus DEFECTIVE ALG9 CAUSES ALG9-CDG (CDG-1L)%REACTOME DATABASE ID RELEASE 72%4720454 Defective ALG9 causes ALG9-CDG (CDG-1l) ALG9 THE NLRP1 INFLAMMASOME%REACTOME DATABASE ID RELEASE 72%844455 The NLRP1 inflammasome BCL2L1 BCL2 NLRP1 UB-SPECIFIC PROCESSING PROTEASES%REACTOME DATABASE ID RELEASE 72%5689880 Ub-specific processing proteases CYLD CCNA2 CCNA1 CDC20 ARRB1 FOXO4 BIRC2 BIRC3 TAF10 USP21 ADRB2 CCP110 SMAD7 TOMM20 USP15 ADRM1 VDAC3 VDAC2 USP30 BECN1 TOMM70A HGS HIST1H2AE HIST1H2AD HIST3H2BB HIST1H2AC HIST1H2AB NFKBIA IKBKG HIST1H2AJ HIST1H2BF HIST1H2BE AR HIST1H2BH HIST1H2BG HIST1H2BB HIST1H2BA WDR48 HIST1H2BD HIST1H2BC SUDS3 MYC SKP2 CDC25A VDAC1 HIST2H2AA3 HIST2H2AA4 USP34 RUVBL1 HIST2H2AC AXIN2 USP11 IFIH1 SMAD4 HIST2H2BE TRRAP CLSPN KAT2A TGFBR1 HIST1H2BN HIST1H2BM CFTR HIST1H2BO HIST1H2BJ HIST1H2BI HIST1H2BL UFD1L HIST1H2BK POLB TADA2B HIST2H2AB USP10 HIST2H2BF PTRH2 USP33 HIST3H2A IL33 USP13 MUL1 TNKS TNKS2 HIST1H2AG RNF146 HIST1H2AA HIST1H2AM USP9X HIST1H2AL HIST1H2AI HIST1H2AH HIST1H2AK SNX3 RCE1 IDE ATXN7 TP53 TADA3 OTUB1 RHOT1 USP17L4 USP17L5 USP17L8 RNF128 USP22 PSMD8 PSMD9 PSMD6 GATA3 WDR20 PSMD7 PSMD4 PSMD5 AXIN1 PSMD2 PSMD3 USP17L2 USP17L3 PSMD1 USP17L1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 DDB2 PSMA2 PSME3 ARRB2 PSME4 USP5 PSME1 PSME2 USP3 SMAD2 UBA52 SMAD3 PSMD10 FKBP8 PSMB11 PSMD12 TAF9B STAM2 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 KEAP1 PSMB6 PSMB7 SMURF2 PSMB4 PSMB5 PSMB2 UBB PSMB3 RNF123 UBC PSMB1 PSMF1 RPS27A DDX58 SIAH2 SHFM1 USP17L30 PSMB8 PSMB9 PSMC5 PSMC6 PSMC3 USP7 PSMC4 PSMC1 USP2 USP18 PSMC2 MAT2B HIF1A USP17L27 USP17L26 USP17L29 USP17L28 RIPK1 USP17L21 USP17L20 TRAF2 USP17L22 USP17L25 USP17L24 USP17L15 USP17L18 USP17L17 USP17L19 USP17L10 USP17L12 USP17L11 USP17L13 SMAD1 MDM2 USP37 USP47 USP4 USP48 USP49 MDM4 USP42 USP44 USP14 USP16 USP12 USP19 TRAF6 USP24 USP25 PTEN USP26 TAB1 USP20 MAP3K7 USP8 USP28 DEFECTS IN BIOTIN (BTN) METABOLISM%REACTOME%R-HSA-3323169.1 Defects in biotin (Btn) metabolism PCCA ACACA PCCB HLCS MCCC2 MCCC1 PC BTD INTRA-GOLGI AND RETROGRADE GOLGI-TO-ER TRAFFIC%REACTOME DATABASE ID RELEASE 72%6811442 Intra-Golgi and retrograde Golgi-to-ER traffic NBAS RAB1B DCTN4 KIF3A STX18 BNIP1 GALNT2 GALNT1 ARCN1 CAPZA3 VAMP4 KIF26A KIF26B CAPZA1 CAPZA2 RAB18 RAB3GAP2 COPG2 NSF COPG1 ACTR10 RAB3GAP1 DYNC1LI1 DYNC1LI2 ARF4 ZW10 KIF5B KIF5A KIF18A NAPA TGOLN2 DYNLL2 KIF2A KIF2C PLA2G6 KIF2B NAPB STX16 GOSR1 GOLIM4 NAPG GBF1 CYTH3 CYTH2 DYNC1I1 RAB41 M6PR GOLGA4 GOLGA5 CYTH4 MAN2A2 CENPE IGF2R CUX1 MAN1A2 VAMP3 MAN2A1 MAN1C1 STX6 VTI1A STX5 MAN1A1 SNAP29 YKT6 CYTH1 COG8 RIC1 COG7 COG6 COG5 COG4 COG3 ACTR1A RAB9B COG2 RAB39A COG1 BET1L RAB33B RGP1 RAB30 RAB36 ALPP TMED2 RAB6A PLA2G4A TRIP11 VPS45 RACGAP1 DYNLL1 ARF3 ARF1 AGPAT3 PAFAH1B1 DYNC1I2 DCTN2 DCTN3 DYNC1H1 RAB43 USP6NL SCOC TMF1 ARFRP1 RHOBTB3 ARL1 VPS51 VPS53 VPS52 VPS54 GCC2 GCC1 GOLGA1 ARFIP2 STX10 SYS1 KDELR1 KIF21A KIF21B RABEPK KIFAP3 NAA30 RINT1 KIF16B KDELR2 NAA35 KIF20A NAA38 KIF20B COPB2 COPA TMED10 COPB1 KLC1 KLC4 KLC3 KLC2 KIF3B KIF3C RAB6B SURF4 KIF18B DCTN1 KIF4B KIF4A GOSR2 COPE KIF11 USE1 BICD1 BICD2 KIF15 PLIN3 KIF19 RAB9A CAPZB KIF13B TMED3 KIF1C KIF1B KIF1A TMED7 TMED9 KIF25 COPZ2 KIF23 KIF22 ARFGAP3 KIF6 ARFGAP1 KIF27 COPZ1 ARFGAP2 KIF9 KIFC2 KIFC1 SEC22B PAFAH1B3 ARF5 PAFAH1B2 KDELR3 DCTN6 RAB1A DCTN5 INTERACTION WITH CUMULUS CELLS AND THE ZONA PELLUCIDA%REACTOME%R-HSA-2534343.2 Interaction With Cumulus Cells And The Zona Pellucida ADAM30 ADAM2 ZP1 ADAM21 ZP3 B4GALT1 ADAM20 ZP2 OVGP1 SPAM1 ZP4 FOLDING OF ACTIN BY CCT TRIC%REACTOME DATABASE ID RELEASE 72%390450 Folding of actin by CCT TriC CCT8 CCT7 CCT6B CCT5 CCT6A CCT4 ACTB CCT3 CCT2 TCP1 KERATAN SULFATE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 72%2022854 Keratan sulfate biosynthesis ST3GAL4 ST3GAL6 ST3GAL1 ST3GAL2 ST3GAL3 B4GALT6 B4GALT4 SLC35D2 B4GALT5 KERA FMOD PRELP CHST6 LUM CHST1 B4GALT2 B4GALT3 B4GALT1 CHST5 CHST2 B4GAT1 OMD OGN B3GNT7 B3GNT4 B3GNT3 B3GNT2 FORMYL PEPTIDE RECEPTORS BIND FORMYL PEPTIDES AND MANY OTHER LIGANDS%REACTOME DATABASE ID RELEASE 72%444473 Formyl peptide receptors bind formyl peptides and many other ligands HEBP1 FPR3 APP ANXA1 SAA1 FPR1 FPR2 P75NTR SIGNALS VIA NF-KB%REACTOME%R-HSA-193639.1 p75NTR signals via NF-kB IKBKB RIPK2 NGFR UBB PRKCI UBC NFKB1 RPS27A UBA52 IRAK1 TRAF6 SQSTM1 NFKBIA MYD88 NGF RELA RECYCLING OF EIF2:GDP%REACTOME DATABASE ID RELEASE 72%72731 Recycling of eIF2:GDP EIF2S2 EIF2S1 EIF2S3 EIF2B1 EIF2B5 EIF2B4 EIF2B3 EIF2B2 DEFECTIVE SLC11A2 CAUSES HYPOCHROMIC MICROCYTIC ANEMIA, WITH IRON OVERLOAD 1 (AHMIO1)%REACTOME DATABASE ID RELEASE 72%5619048 Defective SLC11A2 causes hypochromic microcytic anemia, with iron overload 1 (AHMIO1) SLC11A2 MASTL FACILITATES MITOTIC PROGRESSION%REACTOME%R-HSA-2465910.2 MASTL Facilitates Mitotic Progression PPP2CA PPP2CB CDK1 MASTL PPP2R2D PPP2R1B PPP2R1A ARPP19 CCNB1 ENSA COLLAGEN FORMATION%REACTOME DATABASE ID RELEASE 72%1474290 Collagen formation PCOLCE2 COL17A1 LAMA3 COL18A1 LAMB3 COL15A1 COL16A1 COL13A1 COL14A1 COL11A1 COL11A2 COL12A1 COL19A1 COL10A1 COL28A1 COL26A1 COL27A1 COL24A1 COL25A1 COL22A1 COL23A1 COL1A1 COL3A1 COL2A1 COL1A2 COL4A2 COL5A1 COL4A1 COL6A2 COL7A1 COL4A4 P3H2 COL5A3 P3H1 COL5A2 P3H3 COL6A1 COL4A3 COL8A2 PLEC COL4A6 SERPINH1 COL9A1 COL20A1 MMP20 COL21A1 COL6A3 CTSV COL4A5 COL8A1 CTSS COL9A3 CTSL COL6A6 COL9A2 CTSB COL6A5 MMP13 PXDN MMP3 LOXL3 PLOD3 LOXL4 PLOD2 PLOD1 ADAMTS2 ITGB4 LOXL1 LOXL2 ADAMTS3 ITGA6 PCOLCE LOX PPIB CD151 ADAMTS14 CRTAP P4HA1 P4HA2 P4HB P4HA3 COLGALT2 LAMC2 BMP1 COLGALT1 TLL2 MMP7 MMP9 TLL1 DEFECTIVE CYP11B2 CAUSES CORTICOSTERONE METHYLOXIDASE 1 DEFICIENCY (CMO-1 DEFICIENCY)%REACTOME%R-HSA-5579009.2 Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency) CYP11B2 FCERI MEDIATED CA+2 MOBILIZATION%REACTOME%R-HSA-2871809.1 FCERI mediated Ca+2 mobilization IGKV3-11 LYN VAV1 VAV2 PLCG2 ITPR1 ITPR2 IGKV2-28 ITPR3 PLCG1 SYK SOS1 TEC IGKV3D-20 IGKV1-12 PPP3CA PPP3CB NFATC2 NFATC3 NFATC1 AHCYL1 IGKV2D-28 IGKV4-1 IGKV2D-30 IGHE ITK BTK IGKV5-2 GRAP2 LCP2 VAV3 TXK PPP3R1 THE AIM2 INFLAMMASOME%REACTOME DATABASE ID RELEASE 72%844615 The AIM2 inflammasome CASP1 PYCARD AIM2 MEIOTIC SYNAPSIS%REACTOME%R-HSA-1221632.1 Meiotic synapsis HSPA2 TINF2 TERF2IP SMC3 HIST1H2AE HIST1H2AD HIST3H2BB HIST1H2AC ACD HIST1H2AB HIST1H2AJ HIST1H2BF HIST1H2BE HIST1H2BH HIST1H2BG HIST1H2BB RAD21 HIST1H2BA HIST1H2BD HIST1H2BC STAG1 H2AFB1 STAG2 HIST3H3 TERF1 SMC1A TERF2 POT1 HIST1H4K HIST1H4L H2BFS HIST1H4A HIST1H4B HIST1H4H LMNB1 HIST1H4I HIST1H4J HIST1H4C HIST1H4D HIST1H4E HIST1H4F HIST2H2AA3 HIST2H2AA4 HIST2H2AC H2AFJ H2AFZ H2AFX FKBP6 SYCE3 SYCE2 H2AFV SYCE1 STAG3 SYCP2 SYCP1 HIST2H2BE SYNE2 SYNE1 SUN2 SUN1 HIST4H4 UBE2I TEX12 SMC1B ATR HIST1H2BN HIST1H2BM REC8 HIST1H2BO SYCP3 HIST1H2BJ HIST1H2BI HIST1H2BL BRCA1 HIST1H2BK HIST2H4A HIST2H4B ROS AND RNS PRODUCTION IN PHAGOCYTES%REACTOME%R-HSA-1222556.9 ROS and RNS production in phagocytes LPO ATP6V1B2 CYBB ATP6V0C CYBA ATP6V0D2 ATP6V1B1 ATP6V1A RAC2 ATP6V0A2 ATP6V1H ATP6V0A4 ATP6V0E2 ATP6V1G3 ATP6V1D ATP6V1C1 ATP6V1F ATP6V0A1 ATP6V1C2 MPO NOS2 SLC11A1 NOS3 HVCN1 NCF1 NCF2 NCF4 TCIRG1 NOS1 ATP6V1E1 ATP6V1E2 ATP6V1G1 ATP6V0B ATP6V0E1 ATP6V1G2 ATP6V0D1 ACYL CHAIN REMODELLING OF PI%REACTOME%R-HSA-1482922.2 Acyl chain remodelling of PI PLA2G4C PLA2G4A PLA2G16 PLA2G10 PLA2G1B PLBD1 PLA2R1 PLA2G2F PLA2G2D PLA2G5 PLA2G2E PLA2G12A PLA2G4F MBOAT7 PLA2G2A PLA2G4D GENE SILENCING BY RNA%REACTOME%R-HSA-211000.2 Gene Silencing by RNA POLR2E POLR2F POLR2H NUP107 NUP188 POLR2K POLR2L NUP62 NDC1 NUP214 SEC13 NUP133 NUP210 NUP93 NUP50 NUP54 TNRC6C PLD6 POM121 NUP205 AAAS NUP160 TNRC6A NUP85 POLR2A TNRC6B TPR POLR2B POLR2C NUP88 POLR2D NUP43 POLR2G RAE1 POLR2I POLR2J RANBP2 NUP155 TDRKH DICER1 MOV10L1 NUP153 TARBP2 BCDIN3D PIWIL2 PIWIL1 PIWIL4 TSNAX DDX4 MYBL1 DROSHA NUP35 HENMT1 NUPL2 MAEL TDRD12 TSN NUP37 FKBP6 XPO5 ASZ1 PRKRA TDRD9 TDRD6 TDRD1 AGO3 AGO4 AGO1 AGO2 HIST1H2AE HIST1H2AD HIST3H2BB HIST1H2AC HIST1H2AB HIST1H2AJ HIST2H3A HIST1H2BF HIST1H2BE HIST1H2BH HIST1H2BG HIST2H3D HIST1H2BB HIST1H2BA HIST2H3C HIST1H2BD HIST1H2BC H2AFB1 HIST1H3J HIST1H3A HIST1H3F HIST1H3G HIST1H3H HIST1H3I HIST1H3B HIST1H3C HIST1H3D HIST1H3E H3F3B HIST1H4K HIST1H4L H3F3A H2BFS HIST1H4A HIST1H4B HIST1H4H HIST1H4I HIST1H4J HIST1H4C HIST1H4D HIST1H4E HIST1H4F HIST2H2AA3 HIST2H2AA4 HIST2H2AC RAN H2AFJ HSP90AA1 H2AFZ H2AFX H2AFV HIST2H2BE DGCR8 HIST4H4 HIST1H2BN HIST1H2BM IPO8 HIST1H2BO HIST1H2BJ HIST1H2BI HIST1H2BL HIST1H2BK HIST2H4A HIST2H4B INTESTINAL HEXOSE ABSORPTION%REACTOME DATABASE ID RELEASE 72%8981373 Intestinal hexose absorption SLC5A1 SLC2A5 RSC1A1 SLC2A2 TBC RABGAPS%REACTOME%R-HSA-8854214.1 TBC RABGAPs TSC2 TSC1 TBC1D13 TBC1D14 TBC1D17 TBC1D15 TBC1D16 RAB8B GGA2 RAB33A GGA1 RAB7B RAB35 RAB5A RAB6B RAB7A TBC1D2 TBC1D10C TBC1D3 RAB4A RABEP1 RAB33B TBC1D7 RABGAP1 RAB8A GABARAPL2 RAB6A RAB11B GGA3 ULK1 GABARAP ARF6 RAB5C MAP1LC3B TBC1D20 RABGEF1 RAB11A OPTN RAB5B TBC1D10A TBC1D10B SYTL1 TBC1D24 TBC1D25 PLASMA LIPOPROTEIN REMODELING%REACTOME%R-HSA-8963899.1 Plasma lipoprotein remodeling ALB APOE APOB MBTPS1 APOC3 MBTPS2 LIPC CREB3L3 LIPG APOC2 ANGPTL3 GPIHBP1 LPA ABCG1 CETP C19orf80 LPL LCAT ANGPTL4 LMF2 LMF1 APOF FGF21 APOA2 APOA1 APOA4 APOA5 FURIN PCSK6 PCSK5 SIGNALING BY PLASMA MEMBRANE FGFR1 FUSIONS%REACTOME DATABASE ID RELEASE 72%8853336 Signaling by plasma membrane FGFR1 fusions BAG4 ERLIN2 FGFR1 NR1D1 (REV-ERBA) REPRESSES GENE EXPRESSION%REACTOME%R-HSA-1368071.3 NR1D1 (REV-ERBA) represses gene expression HDAC3 NCOR1 NR1D1 POST NMDA RECEPTOR ACTIVATION EVENTS%REACTOME%R-HSA-438064.3 Post NMDA receptor activation events PDPK1 GRIA2 CAMK2D CAMK2A PRKAR2B PRKAR2A CAMK2G RASGRF2 RPS6KA6 DLG2 DLG1 ACTN2 DLG4 DLG3 RASGRF1 CAMK4 NRGN PRKACG PRKACA ADCY1 PRKACB PRKAA1 ADCY8 GRIN2A PRKAA2 RPS6KA3 RPS6KA2 RPS6KA1 GRIN2C GRIN2B GRIN2D KPNA2 CREB1 MAPK1 MAPK3 PRKAB2 PRKAB1 NEFL NRG1 GIT1 LRRC7 CAMKK1 CAMKK2 HRAS GRIN1 NRAS CAMK1 PRKX PRKAG1 PRKAG2 SRC PRKAG3 RAC1 PRKAR1B PRKAR1A GRIA1 CAMK2B SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER%REACTOME DATABASE ID RELEASE 72%3304351 Signaling by TGF-beta Receptor Complex in Cancer SMAD2 TGFB1 SMAD3 SMAD4 TGFBR1 TGFBR2 FKBP1A SMAC (DIABLO) BINDS TO IAPS%REACTOME%R-HSA-111463.3 SMAC (DIABLO) binds to IAPs CASP7 CASP3 CASP9 APAF1 DIABLO XIAP CYCS P53-INDEPENDENT DNA DAMAGE RESPONSE%REACTOME%R-HSA-69610.3 p53-Independent DNA Damage Response PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 UBA52 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 UBB PSMB3 UBC PSMB1 PSMF1 RPS27A CHEK2 SHFM1 CHEK1 PSMB8 PSMB9 PSMC5 CDC25A PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 EFFECTS OF PIP2 HYDROLYSIS%REACTOME DATABASE ID RELEASE 72%114508 Effects of PIP2 hydrolysis TRPC7 DAGLB TRPC6 TRPC3 PRKCD ITPR1 ITPR2 ITPR3 RASGRP2 RASGRP1 PRKCQ DGKG DGKE MGLL DGKD DGKB DGKA PRKCH ABHD12 DGKZ PRKCE DGKQ DGKK DGKI DGKH ABHD6 DAGLA TOXICITY OF BOTULINUM TOXIN TYPE F (BONT F)%REACTOME DATABASE ID RELEASE 72%5250981 Toxicity of botulinum toxin type F (BoNT F) VAMP1 SV2B SV2A SV2C VAMP2 EVASION OF OXIDATIVE STRESS INDUCED SENESCENCE DUE TO P14ARF DEFECTS%REACTOME%R-HSA-9646304.2 Evasion of Oxidative Stress Induced Senescence Due to p14ARF Defects CDKN2A DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE%REACTOME DATABASE ID RELEASE 72%3359478 Defective MUT causes methylmalonic aciduria mut type MMAA MUT INTERLEUKIN-38 SIGNALING%REACTOME DATABASE ID RELEASE 72%9007892 Interleukin-38 signaling IL1F10 MAPK8 IL1RL2 IL1RAPL1 REGULATION OF TP53 EXPRESSION AND DEGRADATION%REACTOME DATABASE ID RELEASE 72%6806003 Regulation of TP53 Expression and Degradation PPP2CA PDPK1 USP2 PPP2CB AKT1 TP53 MAPKAP1 PPP2R5C CCNA2 CCNA1 UBA52 PPP2R1B PPP2R1A RICTOR RNF34 CDKN2A MTOR PRR5 RFFL CCNG1 ATM UBB CDK2 MDM2 UBC CDK1 MDM4 RPS27A PRDM1 SGK1 PHF20 AKT2 AKT3 CHEK2 MLST8 USP7 DAXX RUNX2 REGULATES OSTEOBLAST DIFFERENTIATION%REACTOME%R-HSA-8940973.1 RUNX2 regulates osteoblast differentiation HDAC3 HEY1 HEY2 AR SP7 YES1 ABL1 HDAC6 HES1 BGLAP YAP1 ZNF521 CBFB GLI3 SATB2 RB1 COL1A1 WWTR1 SRC MAF MAPK1 UCMA MAPK3 BIOSYNTHESIS OF DPAN-6 SPMS%REACTOME%R-HSA-9025106.1 Biosynthesis of DPAn-6 SPMs ALOX15 ALOX12 INWARDLY RECTIFYING K+ CHANNELS%REACTOME DATABASE ID RELEASE 72%1296065 Inwardly rectifying K+ channels GNG11 KCNJ1 GNG13 KCNJ3 ABCC8 KCNJ5 GNB2 KCNJ6 KCNJ10 GNB1 GNB4 KCNJ2 KCNJ9 KCNJ15 GNB3 KCNJ4 KCNJ16 KCNJ12 GNB5 KCNJ14 GNGT1 GNGT2 KCNJ11 GABBR2 GABBR1 GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 KCNJ8 ABCC9 GNG10 GNG12 CREB1 PHOSPHORYLATION THROUGH NMDA RECEPTOR-MEDIATED ACTIVATION OF RAS SIGNALING%REACTOME%R-HSA-442742.2 CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling PDPK1 CAMK2D CAMK2A NEFL CAMK2G RASGRF2 LRRC7 RPS6KA6 DLG2 DLG1 ACTN2 DLG4 DLG3 RASGRF1 RPS6KA3 RPS6KA2 RPS6KA1 HRAS GRIN2B GRIN2D GRIN1 NRAS CREB1 MAPK1 MAPK3 CAMK2B DEFECTIVE ABCG8 CAUSES GALLBLADDER DISEASE 4 AND SITOSTEROLEMIA%REACTOME%R-HSA-5679090.1 Defective ABCG8 causes gallbladder disease 4 and sitosterolemia ABCG8 ABCG5 EARLY PHASE OF HIV LIFE CYCLE%REACTOME%R-HSA-162594.2 Early Phase of HIV Life Cycle LIG1 CD4 PPIA PSIP1 BANF1 CCR5 KPNA1 HMGA1 CXCR4 LIG4 XRCC6 XRCC4 FEN1 XRCC5 HEME BIOSYNTHESIS%REACTOME%R-HSA-189451.2 Heme biosynthesis ALB CPOX ALAD UROD COX10 FECH PPOX HMBS UROS ABCG2 COX15 ALAS2 ALAS1 COHESIN LOADING ONTO CHROMATIN%REACTOME%R-HSA-2470946.1 Cohesin Loading onto Chromatin MAU2 WAPAL PDS5B NIPBL PDS5A SMC1A SMC3 RAD21 STAG1 STAG2 IRE1ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 72%381070 IRE1alpha activates chaperones PPP2R5B EDEM1 SYVN1 ACADVL SULT1A3 HSPA5 SEC31A GSK3A SHC1 ERN1 CUL7 DCTN1 FKBP14 GOSR2 SRPR CXXC1 PLA2G4B ADD1 MYDGF EXTL2 EXTL1 SERP1 TATDN2 LMNA DNAJB9 SSR1 EXTL3 TSPYL2 ZBTB17 KLHDC3 WFS1 DDX11 GFPT1 WIPI1 PDIA6 YIF1A ARFGAP1 PDIA5 DNAJC3 CTDSP2 DNAJB11 SRPRB TPP1 PREB HDGF HYOU1 KDELR3 TLN1 ATP6V0D1 RECRUITMENT AND ATM-MEDIATED PHOSPHORYLATION OF REPAIR AND SIGNALING PROTEINS AT DNA DOUBLE STRAND BREAKS%REACTOME DATABASE ID RELEASE 72%5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks WHSC1 HERC2 PIAS4 RNF8 UBA52 BRCC3 MAPK8 TP53BP1 HIST3H2BB KDM4A KDM4B EYA1 EYA2 MRE11A EYA3 HIST1H2BF EYA4 HIST1H2BE PPP5C HIST1H2BH HIST1H2BG HIST1H2BB HIST1H2BA BAP1 BRE HIST1H2BD HIST1H2BC UBB HIST3H3 BABAM1 UIMC1 MDC1 UBC RPS27A KAT5 RNF168 RAD50 CHEK2 NBN HIST1H4K HIST1H4L SMARCA5 H2BFS APBB1 HIST1H4A HIST1H4B HIST1H4H HIST1H4I HIST1H4J HIST1H4C HIST1H4D HIST1H4E UBE2N TP53 HIST1H4F BARD1 UBE2V2 H2AFX BAZ1B HIST2H2BE ABL1 ATM HIST4H4 UBE2I HIST1H2BN HIST1H2BM HIST1H2BO HIST1H2BJ HIST1H2BI FAM175A HIST1H2BL BRCA1 HIST1H2BK HIST2H4A SUMO1 HIST2H4B METABOLISM OF INGESTED H2SEO4 AND H2SEO3 INTO H2SE%REACTOME DATABASE ID RELEASE 72%2408550 Metabolism of ingested H2SeO4 and H2SeO3 into H2Se TXNRD1 PAPSS2 PAPSS1 UREA CYCLE%REACTOME DATABASE ID RELEASE 72%70635 Urea cycle ARG1 ASS1 OTC ASL NMRAL1 SLC25A15 CPS1 SLC25A2 NAGS ARG2 DEFECTIVE SLC35D1 CAUSES SCHNECKENBECKEN DYSPLASIA (SCHBCKD)%REACTOME DATABASE ID RELEASE 72%5579020 Defective SLC35D1 causes Schneckenbecken dysplasia (SCHBCKD) SLC35D1 DEGRADATION OF AXIN%REACTOME%R-HSA-4641257.2 Degradation of AXIN PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 UBA52 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 SMURF2 PSMB4 PSMB5 PSMB2 UBB PSMB3 TNKS TNKS2 UBC PSMB1 PSMF1 RNF146 RPS27A SHFM1 PSMB8 PSMB9 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 AXIN2 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 AXIN1 PSMD2 TRANSCRIPTION OF E2F TARGETS UNDER NEGATIVE CONTROL BY P107 (RBL1) AND P130 (RBL2) IN COMPLEX WITH HDAC1%REACTOME%R-HSA-1362300.2 Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 RBBP4 E2F1 E2F4 LIN54 LIN52 CDK1 RBL2 CCNA2 TFDP1 MYBL2 HDAC1 RBL1 LIN37 TFDP2 LIN9 E2F5 PRC2 METHYLATES HISTONES AND DNA%REACTOME DATABASE ID RELEASE 72%212300 PRC2 methylates histones and DNA RBBP4 RBBP7 SUZ12 HIST1H2AE HIST1H2AD HIST3H2BB HIST1H2AC HIST1H2AB HIST1H2AJ HIST2H3A HIST1H2BF HIST1H2BE HIST1H2BH HIST1H2BG HIST2H3D HIST1H2BB HIST1H2BA HIST2H3C HIST1H2BD HIST1H2BC H2AFB1 DNMT1 HIST1H3J HIST1H3A HIST1H3F HIST1H3G HIST1H3H HIST1H3I HIST1H3B HIST1H3C HIST1H3D HIST1H3E H3F3B HIST1H4K HIST1H4L H3F3A H2BFS HIST1H4A HIST1H4B HIST1H4H HIST1H4I HIST1H4J HIST1H4C HIST1H4D HIST1H4E PHF19 EZH2 HIST1H4F HIST2H2AA3 HIST2H2AA4 PHF1 HIST2H2AC H2AFJ DNMT3B JARID2 EED H2AFZ DNMT3A H2AFX H2AFV HIST2H2BE AEBP2 HIST4H4 MTF2 HIST1H2BN HIST1H2BM HIST1H2BO HIST1H2BJ HIST1H2BI HIST1H2BL HIST1H2BK HIST2H4A HIST2H4B NETRIN-1 SIGNALING%REACTOME%R-HSA-373752.2 Netrin-1 signaling TRPC7 TRPC6 TRPC3 PTPN11 HFE2 EZR DOCK1 RGMB RGMA MAPK8 CDC42 PAK1 DSCAM PRKCQ MYO10 SLIT1 SLIT3 SLIT2 ROBO1 PTK2 MAPK12 MAPK13 SIAH2 SIAH1 MAPK14 MAPK11 NTN4 WASL NEO1 PLCG1 UNC5A UNC5B UNC5C UNC5D AGAP2 TRIO DSCAML1 DCC PITPNA NTN1 TRPC5 TRPC4 TRPC1 SRC RAC1 ABLIM1 NCK1 ABLIM2 ABLIM3 DEFECTIVE CYP11A1 CAUSES ADRENAL INSUFFICIENCY, CONGENITAL, WITH 46,XY SEX REVERSAL (AICSR)%REACTOME DATABASE ID RELEASE 72%5579026 Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR) FDXR CYP11A1 FDX1 FDX1L DRUG RESISTANCE IN ERBB2 TMD JMD MUTANTS%REACTOME DATABASE ID RELEASE 72%9665737 Drug resistance in ERBB2 TMD JMD mutants ERBB2IP HSP90AA1 CDC37 ERBB2 TRAFFICKING OF AMPA RECEPTORS%REACTOME%R-HSA-399719.1 Trafficking of AMPA receptors GRIA2 CAMK2D CAMK2A AKAP5 GRIP1 CACNG8 EPB41L1 PRKCA TSPAN7 MYO6 CACNG2 CAMK2G CACNG3 GRIA3 CACNG4 GRIA4 PRKCG NSF DLG1 DLG4 PICK1 MDM2 AP2A1 GRIA1 CAMK2B PRKCB PLC-GAMMA1 SIGNALLING%REACTOME DATABASE ID RELEASE 72%167021 PLC-gamma1 signalling PLCG1 NTRK1 NGF CLEARANCE OF SERATONIN%REACTOME%R-HSA-380615.3 Clearance of seratonin ALDH2 MAOA SLC6A4 DEFECTIVE GFPT1 CAUSES CMSTA1%REACTOME DATABASE ID RELEASE 72%4085023 Defective GFPT1 causes CMSTA1 GFPT1 OREXIN AND NEUROPEPTIDES FF AND QRFP BIND TO THEIR RESPECTIVE RECEPTORS%REACTOME DATABASE ID RELEASE 72%389397 Orexin and neuropeptides FF and QRFP bind to their respective receptors HCRTR2 HCRTR1 NPFFR2 QRFPR QRFP NPFFR1 NPFF HCRT KETONE BODY METABOLISM%REACTOME DATABASE ID RELEASE 72%74182 Ketone body metabolism ACSS3 AACS ACAT1 BDH2 HMGCLL1 BDH1 HMGCS2 OXCT1 HMGCL OXCT2 CRNA SYNTHESIS%REACTOME DATABASE ID RELEASE 72%192869 cRNA Synthesis ASSEMBLY OF VIRAL COMPONENTS AT THE BUDDING SITE%REACTOME DATABASE ID RELEASE 72%168316 Assembly of Viral Components at the Budding Site CALR CANX TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION%REACTOME DATABASE ID RELEASE 72%1474151 Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation GCHFR AKT1 GCH1 NOS3 SPR DHFR HSP90AA1 PRKG2 PTS DOWNSTREAM SIGNAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 72%186763 Downstream signal transduction RAPGEF1 PDGFB STAT1 PTPN11 CRK PDGFRA PIK3R1 PIK3R2 PIK3CA PLCG1 SOS1 HRAS RASA1 CRKL STAT5A STAT5B NRAS BCAR1 PIK3CB STAT6 GRB7 STAT3 SRC NCK2 NCK1 PDGFRB RESISTANCE OF ERBB2 KD MUTANTS TO NERATINIB%REACTOME DATABASE ID RELEASE 72%9665246 Resistance of ERBB2 KD mutants to neratinib ERBB2IP HSP90AA1 CDC37 ERBB2 TRANSPORT OF ORGANIC ANIONS%REACTOME%R-HSA-879518.2 Transport of organic anions SLCO4C1 ALB SLCO2A1 SLCO2B1 AVP SLCO1A2 SLC16A2 SLCO1B1 SLCO1B3 SLCO1C1 SLCO4A1 G BETA:GAMMA SIGNALLING THROUGH PLC BETA%REACTOME DATABASE ID RELEASE 72%418217 G beta:gamma signalling through PLC beta GNG11 GNG13 GNB2 GNB1 GNB4 GNB3 GNG3 PLCB3 GNG2 GNG5 GNB5 GNG4 GNG7 GNG8 PLCB1 GNGT1 PLCB2 GNGT2 GNG10 GNG12 EVASION OF ONCOGENE INDUCED SENESCENCE DUE TO P14ARF DEFECTS%REACTOME%R-HSA-9646303.2 Evasion of Oncogene Induced Senescence Due to p14ARF Defects CDKN2A MPS VI - MAROTEAUX-LAMY SYNDROME%REACTOME DATABASE ID RELEASE 72%2206285 MPS VI - Maroteaux-Lamy syndrome ARSB TNFR1-MEDIATED CERAMIDE PRODUCTION%REACTOME DATABASE ID RELEASE 72%5626978 TNFR1-mediated ceramide production TNFRSF1A SMPD3 NSMAF SMPD2 TNF GNB2L1 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS)%REACTOME DATABASE ID RELEASE 72%456926 Thrombin signalling through proteinase activated receptors (PARs) GNG11 GNG13 GNB2 GNB1 GNB4 GNB3 GNB5 ARRB2 GNGT1 GNA12 GNGT2 GNA14 GNA15 GNA11 ARRB1 F2RL2 F2RL3 GNG3 F2R GNG2 GNG5 GNG4 F2 GNG7 GNG8 GNAQ GNA13 GNG10 MAPK1 MAPK3 GNG12 DEFECTIVE NTHL1 SUBSTRATE PROCESSING%REACTOME DATABASE ID RELEASE 72%9630221 Defective NTHL1 substrate processing NTHL1 MPS I - HURLER SYNDROME%REACTOME DATABASE ID RELEASE 72%2206302 MPS I - Hurler syndrome IDUA FRUCTOSE METABOLISM%REACTOME DATABASE ID RELEASE 72%5652084 Fructose metabolism ALDOB KHK GLYCTK TKFC AKR1B1 ALDH1A1 SORD AQUAPORIN-MEDIATED TRANSPORT%REACTOME DATABASE ID RELEASE 72%445717 Aquaporin-mediated transport PRKAR2B PRKAR2A GNAS ADCY4 ADCY3 PRKACG ADCY2 PRKACA ADCY1 PRKACB ADCY8 ADCY7 ADCY6 ADCY5 RAB11A GNG10 AQP12A GNG12 AQP8 GNG11 AQP10 GNG13 AQP9 AQP6 AQP7 GNB2 AQP4 AVP AQP5 GNB1 AQP2 GNB4 AQP3 AQP1 GNB3 MIP AQP11 GNB5 GNGT1 GNGT2 AVPR2 GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 RAB11FIP2 MYO5B ADCY9 PRKAR1B PRKAR1A JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1%REACTOME%R-HSA-450321.2 JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 MAP2K4 RIPK2 UBE2N UBE2V1 NOD1 NOD2 MAPK9 MAPK8 IRAK1 IRAK2 MAP2K7 TRAF6 TAB3 MAPK10 TAB2 TAB1 IKBKG MAP3K7 SIGNALING BY ERBB2%REACTOME DATABASE ID RELEASE 72%1227986 Signaling by ERBB2 AKT1 NRG1 PTPN12 PRKCD YES1 PRKCA NRG2 NRG3 NRG4 EGF SHC1 GAB1 PIK3R1 EGFR PTK6 UBA52 PIK3CA PLCG1 RNF41 SOS1 ERBB2IP HSP90AA1 CDC37 ERBB2 FYN HRAS BTC PTPN18 RHOA NRAS UBB MATK HBEGF EREG UBC STUB1 RPS27A GRB7 CUL5 AKT2 PRKCE AKT3 SRC MEMO1 USP8 DIAPH1 BASE-EXCISION REPAIR, AP SITE FORMATION%REACTOME DATABASE ID RELEASE 72%73929 Base-Excision Repair, AP Site Formation TDG TINF2 NEIL3 TERF2IP NEIL2 NEIL1 HIST1H2AE NTHL1 HIST1H2AD HIST3H2BB HIST1H2AC ACD HIST1H2AB HIST1H2AJ HIST1H2BF HIST1H2BE SMUG1 HIST1H2BH HIST1H2BG HIST1H2BB HIST1H2BA HIST1H2BD OGG1 HIST1H2BC H2AFB1 HIST3H3 TERF1 TERF2 POT1 HIST1H4K HIST1H4L H2BFS HIST1H4A MBD4 HIST1H4B HIST1H4H HIST1H4I HIST1H4J HIST1H4C HIST1H4D HIST1H4E MPG HIST1H4F HIST2H2AA3 HIST2H2AA4 HIST2H2AC H2AFJ H2AFZ H2AFX H2AFV HIST2H2BE HIST4H4 HIST1H2BN HIST1H2BM HIST1H2BO HIST1H2BJ HIST1H2BI HIST1H2BL HIST1H2BK HIST2H4A HIST2H4B ACTIVATED NTRK2 SIGNALS THROUGH RAS%REACTOME%R-HSA-9026519.1 Activated NTRK2 signals through RAS HRAS NTRK2 SOS1 BDNF NRAS NTF4 TICAM1-DEPENDENT ACTIVATION OF IRF3 IRF7%REACTOME DATABASE ID RELEASE 72%9013973 TICAM1-dependent activation of IRF3 IRF7 UBC TANK RPS27A UBA52 TBK1 IRF3 TRAF3 TICAM1 UBB IRF7 TLR3 IKBKE NEGATIVE REGULATION OF NMDA RECEPTOR-MEDIATED NEURONAL TRANSMISSION%REACTOME%R-HSA-9617324.1 Negative regulation of NMDA receptor-mediated neuronal transmission CAMK2D CAMK2A NEFL GRIN2C GRIN2B GRIN2D GRIN1 CAMK2G CAMK1 LRRC7 DLG2 DLG1 ACTN2 DLG4 DLG3 CAMK4 PPM1E PPM1F GRIN2A CAMK2B RHO GTPASES ACTIVATE WASPS AND WAVES%REACTOME DATABASE ID RELEASE 72%5663213 RHO GTPases Activate WASPs and WAVEs WIPF1 WIPF2 WIPF3 ARPC1B ARPC1A WASL WAS ACTG1 ACTB NCKIPSD CDC42 ARPC4 NCKAP1L ARPC5 ARPC2 WASF1 ARPC3 WASF2 ACTR3 WASF3 ACTR2 BAIAP2 ABL1 PTK2 CYFIP2 CYFIP1 ABI2 NCKAP1 ABI1 BRK1 BTK MAPK1 RAC1 NCK1 MAPK3 SENSING OF DNA DOUBLE STRAND BREAKS%REACTOME DATABASE ID RELEASE 72%5693548 Sensing of DNA Double Strand Breaks KPNA2 RAD50 KAT5 ATM NBN MRE11A NEDDYLATION%REACTOME DATABASE ID RELEASE 72%8951664 Neddylation BTBD1 CUL1 UBE2F KLHL25 ZBTB16 KLHL21 KLHL22 BTBD6 FBXO30 KLHL20 FBXO31 BIRC5 KBTBD13 ASB13 ASB14 ASB11 RNF7 ASB12 ASB17 ASB18 FBXL22 ASB15 SOCS2 ASB16 FBXL20 CISH ASB10 FBXL19 FBXL15 FBXL16 FBXL13 FBXL14 FBXL12 ASB8 ASB9 ASB6 ASB7 ASB4 ASB5 ASB2 ASB1 SENP8 UCHL3 FBXW11 CUL3 KBTBD7 COPS7B COPS7A DCAF7 VHL FBXO4 FBXO6 UBE2D1 SOCS3 FBXW4 FBXW5 FBXW10 FBXW7 FBXW9 FBXW2 DDB1 GPS1 UBE2D2 SKP2 UBE2D3 HIF3A CUL2 FBXL3 FBXL5 CUL7 COPS4 COPS3 COPS6 COPS5 COPS2 COPS8 FBXO32 RBBP7 DTL UBA3 SOCS6 UBE2M DDA1 SOCS5 SPSB3 CUL4A COMMD9 CCDC8 ERCC8 NAE1 CUL4B COMMD10 FEM1C FEM1A FEM1B COMMD3 COMMD8 NEDD8 CAND1 COMMD2 COMMD1 COMMD6 COMMD7 COMMD4 COMMD5 KCTD6 WDR5 DCAF8 DCAF5 DCAF4 FBXL7 DCAF6 RBBP5 FBXL18 WSB2 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 DDB2 PSMA2 PSME3 PSME4 PSME1 PSME2 UBA52 TCEB2 PSMD10 TCEB1 PSMB11 PSMD12 CUL9 PSMD11 PSMD14 WDTC1 PSMD13 PSMA7 CCDC22 LRR1 PSMB10 CCNF PSMA8 KEAP1 PSMB6 PSMB7 TULP4 PSMB4 DCAF16 FBXO7 PSMB5 DCAF17 FBXO9 PSMB2 UBB WSB1 PSMB3 FBXO2 RFWD2 UBC PSMB1 DCAF10 PSMF1 DCAF11 RPS27A SHFM1 PSMB8 PSMB9 FBXL8 PSMC5 FBXL4 PSMC6 OBSL1 PSMC3 DCUN1D5 PSMC4 DCUN1D3 PSMC1 DCUN1D4 PSMC2 DCUN1D1 DCUN1D2 GPR75-ASB3 PUM2 LRRC41 ANKRD9 GAN UBXN7 KLHL2 KLHL3 EPAS1 HIF1A KLHL9 SPSB2 SPSB1 KBTBD6 KLHL5 KBTBD8 SPSB4 FBXO27 FBXO21 FBXO22 FBXW12 FBXW8 UBD FBXO17 DCAF13 FBXO15 LMO7 FBXO10 FBXO11 KLHL41 KLHL42 BTRC KCTD7 SKP1 CUL5 RBX1 KLHL11 KLHL13 FBXO44 NEURL2 FBXO41 FBXO40 DEFECTIVE DHDDS CAUSES RETINITIS PIGMENTOSA 59%REACTOME DATABASE ID RELEASE 72%4755609 Defective DHDDS causes retinitis pigmentosa 59 NUS1 DHDDS HEMOSTASIS%REACTOME%R-HSA-109582.2 Hemostasis PRKAR2B KIF3A PRKAR2A KIF26A KIF26B GNAS CAPZA1 CAPZA2 PPP2R5C GNA14 GNA15 APP GNA11 ARRB1 SPARC DGKG DGKE DGKD DGKB KIF18A DGKA ABHD12 DGKZ DGKQ STX4 DGKK KIF2A DGKI KIF2C DGKH KIF2B ABHD6 DAGLA JAM2 JAM3 LCK DAGLB CENPE PPIA PLA2G4A HRAS F2RL2 F2RL3 MGLL TGFB2 TGFB3 NRAS CFD PLG PDGFB APOOL GNA12 SERPINE2 SERPINC1 PROS1 F13A1 PRCP TFPI KNG1 SERPINA5 SLC16A1 THBD C1QBP A2M PF4V1 CD177 FGB FGA SERPIND1 GNAT3 VWF F10 GP1BB F12 F11 F2R FGG GP1BA F2 GP5 F5 F7 SLC16A8 PROCR GP9 SLC16A3 F8 LAT PROC F9 TUBA4A SERPING1 F13B PRTN3 KLKB1 PF4 GNG10 GNG12 GNG11 GNG13 GNB2 GNB1 GNB4 GNB3 ACTN1 GNB5 PIK3CG ITGA6 EGF SHC1 GNGT1 PIK3R1 GNGT2 PIK3CA PLCG1 SOS1 CABLES1 WEE1 TGFB1 GNAI3 GNAI1 GNAI2 F11R PRKCZ GNG3 RHOA GNG2 GNG5 GNG4 GNG7 GNG8 LRP8 IFNB1 VEGFA ACTN4 RBSN SOD1 JAK2 ACTN2 PPP2R1B SH2B3 PPP2R1A PRKACG PFN1 PRKACA PRKACB TREM1 SPP2 PPP2R5D PIK3R3 KDM1A KIF5B KIF5A PLAUR PIK3R6 PIK3R5 SLC8A1 SLC8A2 SERPINE1 ALDOA CD109 CEACAM5 ATP1B3 PPP2CA ATP1B2 PPP2CB RAB27B ATP1B1 CALU STIM1 P2RY1 PHF21A ORAI2 ORAI1 IGF1 GATA4 CD36 SLC7A5 HMG20B CD44 MPL THPO GPC1 RAPGEF3 ATP2A3 ITGB3 ATP2A2 RAPGEF4 ATP2A1 PIK3CB NOS1 IRF1 IRF2 MYB GATA3 ITGAV LCP2 RAC1 VAV3 PRKCB PDPK1 SRI VAV1 CFL1 VAV2 CBX5 CRK DOCK1 ATP2B4 ITPR1 ATP2B3 ITPR2 ATP2B2 ITPR3 ATP2B1 PIK3R2 SLC8A3 CDC42 FYN NOS3 CAV1 PTK2 HGF RAP1A STXBP3 F3 BCAR1 HSPA5 CXADR MAPK1 MAPK3 IFNA5 IFNA4 IFNA7 IFNA6 IFNA1 IFNA2 MAPK14 IFNA8 IFNA13 CDK5 IFNA14 IFNA16 IFNA17 IFNA10 ABCC4 IFNA21 TNFRSF10B TNFRSF10A ITGA4 TBXA2R APLP2 SCG3 PRKCH ISLR HABP4 CHID1 SERPINF2 MAG ITGB1 GTPBP2 SYTL4 BSG DOCK7 SEPP1 GRB7 ANGPT4 TAGLN2 NHLRC2 ANGPT2 ANGPT1 TEX264 ENDOD1 DOK2 GRB14 APOH VTI1B SLC7A11 TEK MANF SLC7A10 ITGA3 MAGED2 HRG ITGA2 FERMT3 SLC7A6 ECM1 SLC7A7 SDC4 OLA1 SLC7A8 SDC2 CTSW SERPINA4 SLC7A9 SDC3 TMSB4X TIMP3 ANXA5 TSPAN7 TOR4A LY6G6F PLCG2 CD74 LHFPL2 GATA6 PCYOX1L FAM49B APOB FAM3C TMX3 RARRES2 PRKCG SCCPDH LGALS3BP WDR1 PLEK PICK1 PHACTR2 SRGN MMRN1 ITIH4 ITIH3 RASGRP2 C6orf25 CLEC3B CDC37L1 PDPN RASGRP1 CLEC1B PCDH7 SDC1 GP6 SERPINB2 CD99 IGKV1-12 DOCK3 AMICA1 ITPK1 IGKV2D-28 IGKV4-1 GNA13 IGKV2D-30 IGKV3-11 LYN YES1 ANXA2 ITGA1 IGKV2-28 SYK SERPINB8 S100A10 IGKV3D-20 VPS45 AKAP1 GNAQ PSAP IGKV5-2 MFN1 ALB MFN2 IGF2 SLC3A2 GAS6 ADRA2C ADRA2A RAB5A HIST2H3A PRKCQ HIST2H3D HIST2H3C L1CAM ITGA5 HIST1H3J LEFTY2 HIST1H3A GATA5 HIST1H3F EHD1 HIST1H3G EHD2 HIST1H3H EHD3 HIST1H3I AK3 MAFG HIST1H3B MAFF HIST1H3C RAD51B MAFK HIST1H3D LRRC16A HIST1H3E H3F3B SH2B1 RAD51C PLAT CABLES2 JMJD1C ZFPM2 A1BG H3F3A MICAL1 HBD AKAP10 DOCK10 DOCK11 HBE1 HBG2 HBG1 DOCK6 DOCK5 DOCK4 DOCK9 DOCK8 SERPINA3 SERPINA1 INPP5D OLR1 AHSG SERPINB6 SIN3A TTN THBS1 ABL1 LAMP2 HDAC2 HDAC1 TLN1 ITGAM ITGB2 ITGAL RAF1 ITGAX TIMP1 MIF CD84 SIRPG VPREB3 VPREB1 DOCK2 PSG1 STXBP2 PSG3 PSG2 PSG9 FCAMR PSG8 PRKG2 PSG5 PSG4 PSG6 GYPA GYPC PPBP GYPB CD99L2 ORM1 PSG11 GLG1 HBB IGHA1 ORM2 SELE APOA1 SELP ESAM JCHAIN QSOX1 SPN CD48 CAP1 SELPLG EPCAM PPIL2 FCER1G MERTK MMP1 CD2 IGLL1 CEACAM3 CD244 CEACAM1 CEACAM6 CEACAM8 CD47 CD63 TP53 CD58 TF CLU GUCY1A3 GUCY1B3 PLAU GUCY1A2 SIRPA NOS2 PDE1B PDE1A PDE2A PDE11A PDE10A KCNMB1 KCNMA1 KCNMB2 KCNMB3 KCNMB4 MRVI1 PDE5A PDE9A SELL RACGAP1 FIGF PRKCE VEGFB VEGFC P2RY12 SRC CSK AAMP PPP2R5E TRPC7 AKT1 PTGIR TRPC6 TRPC3 PPP2R5B PRKCD PPP2R5A PRKCA FGR PTPN11 YWHAZ PAFAH2 RAC2 P2RX7 P2RX6 RHOG P2RX5 ITGA2B P2RX4 P2RX3 P2RX2 ARRB2 P2RX1 PTPN6 RHOB APBB1IP VCL RAP1B ZFPM1 GATA2 GATA1 FN1 NFE2 CYB5R1 FLNA KIF21A KIF21B KIFAP3 ITGA10 KIF16B KIF20A KIF20B PTPN1 KLC1 KLC4 KLC3 KLC2 KIF3B KIF3C BRPF3 KIF18B KIF4B KIF4A TNFRSF10D KIF11 KIF15 KIF19 CAPZB KIF13B KIF1C KIF1B KIF1A CDK2 KIF25 KIF23 KIF22 KIF6 KIF27 KIF9 KIFC2 KIFC1 CD9 PRKAR1B PRKAR1A ONCOGENE INDUCED SENESCENCE%REACTOME%R-HSA-2559585.6 Oncogene Induced Senescence TNRC6A TNRC6B ERF E2F2 E2F3 ID1 TP53 CDK6 UBA52 TFDP1 CDK4 TFDP2 CDKN2A MOV10 AGO3 E2F1 AGO4 AGO1 UBB MDM2 UBC MDM4 RPS27A TNRC6C SP1 RB1 ETS1 ETS2 CDKN2D MAPK1 CDKN2B CDKN2C MAPK3 N-GLYCAN TRIMMING AND ELONGATION IN THE CIS-GOLGI%REACTOME%R-HSA-964739.1 N-glycan trimming and elongation in the cis-Golgi MANEA MAN1A2 MAN1C1 MGAT1 MAN1A1 XAV939 INHIBITS TANKYRASE, STABILIZING AXIN%REACTOME DATABASE ID RELEASE 72%5545619 XAV939 inhibits tankyrase, stabilizing AXIN TNKS2 TNKS RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING%REACTOME%R-HSA-73779.2 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening GTF2F1 TAF2 GTF2B GTF2F2 CDK7 GTF2A1 POLR2A GTF2A2 POLR2B TAF1 POLR2C GTF2E1 POLR2D GTF2E2 POLR2G POLR2E MNAT1 POLR2F POLR2H POLR2I POLR2J AK6 POLR2K CCNH POLR2L GTF2H1 GTF2H2 GTF2H3 GTF2H4 TAF9B GTF2H5 TBP ERCC3 ERCC2 TAF9 TAF1L TAF15 TAF12 TAF13 TAF4B TAF10 TAF11 TAF7 TAF6 TAF5 TAF7L TAF4 TAF3 GLI PROTEINS BIND PROMOTERS OF HH RESPONSIVE GENES TO PROMOTE TRANSCRIPTION%REACTOME DATABASE ID RELEASE 72%5635851 GLI proteins bind promoters of Hh responsive genes to promote transcription GLI1 GLI3 GLI2 ERK1 ERK2 PATHWAY%REACTOME%R-HSA-5684996.4 ERK1 ERK2 pathway CAMK2D CAMK2A RANBP9 CAMK2G RASGRF2 PPP2R5C DLG1 DLG4 RASGRP1 RASGRP3 ARRB1 IL2RG JAK3 DUSP5 DUSP2 DUSP1 DUSP8 DUSP9 IL6 DUSP16 DUSP10 PEA15 IQGAP1 SPRED3 PHB SPRED2 SPRED1 SYNGAP1 HRAS RASA3 RASA4 RASA1 RASA2 CUL3 BTC RASAL1 EPGN RASAL2 TGFA RASAL3 AREG NRAS HBEGF DAB2IP EREG NF1 KBTBD7 PDGFRB KIT PDGFB SPTAN1 PPP5C FGB FGA VWF FGG IRS1 IRS2 CDK1 WDR83 PAQR3 BRAP RET GFRA3 IL17RD RAPGEF2 IL5RA SHC3 RASGRP4 IL5 MAP3K11 RASGEF1A IL3RA IL2RB NRTN GFRA1 SPTB EGF GFRA2 SHC1 GFRA4 SPTBN4 SPTBN5 EGFR SPTA1 SOS1 SPTBN1 SPTBN2 PSPN GDNF PTPRA ARTN TLN1 MAP2K1 MAP2K2 BRAF RAF1 JAK2 ACTN2 FGF6 FGF9 PPP2R1B PPP2R1A FGF20 FGF1 FGF2 FGF23 FGF3 FGF22 FGF10 FGF4 PPP2R5D GRIN2B GRIN2D CSF2RB CSF2RA PPP2CA PPP2CB NEFL LRRC7 GRIN1 ITGB3 YWHAB PSMD8 PSMD9 PSMD6 SRC PSMD7 PSMD4 PSMD5 IL3 CSK PSMD2 PPP2R5E PSMD3 NCAM1 PSMD1 PPP2R5B PPP2R5A PTPN11 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 ITGA2B SHC2 ARAF PSMA2 PEBP1 PSME3 ARRB2 PSME4 DLG2 PSME1 PSME2 DLG3 KSR1 UBA52 RASGRF1 KSR2 PSMD10 APBB1IP PSMB11 CNKSR2 PSMD12 CNKSR1 PSMD11 PSMD14 VCL FYN PSMD13 PSMA7 PSMB10 PSMA8 RAP1B MARK3 FN1 PSMB6 DUSP4 PSMB7 PTK2 HGF PSMB4 MET RAP1A PSMB5 PSMB2 LAMTOR2 KLB CSF2 UBB FLT3 PSMB3 DUSP6 LAMTOR3 FLT3LG DUSP7 UBC PSMB1 PSMF1 IL2 FGF19 FGFR4 JAK1 RPS27A IL2RA SHFM1 PSMB8 PSMB9 PSMC5 MAPK1 PSMC6 PSMC3 MAPK3 PSMC4 PSMC1 PSMC2 NRG1 NRG2 FRS2 FRS3 FGF16 NRG3 FGF7 NRG4 FGF18 PDGFRA ERBB2 TYK2 IL6R ANGPT1 RBX1 TEK CAMK2B FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION%REACTOME DATABASE ID RELEASE 72%983231 Factors involved in megakaryocyte development and platelet production PRKAR2B RBSN KIF3A PRKAR2A KIF26A GATA6 KIF26B CAPZA1 CAPZA2 JAK2 SH2B3 PRKACG PRKACA PRKACB DOCK2 DOCK3 ITPK1 KDM1A KIF5B KIF5A KIF18A HBB KIF2A KIF2C KIF2B CENPE PHF21A TP53 GATA4 HMG20B VPS45 AKAP1 RACGAP1 IRF1 IRF2 MYB GATA3 RAC1 MFN1 MFN2 CBX5 DOCK1 CDC42 RAB5A HIST2H3A ZFPM1 GATA2 GATA1 HIST2H3D NFE2 HIST2H3C HIST1H3J HIST1H3A GATA5 HIST1H3F HIST1H3G EHD1 HIST1H3H EHD2 HIST1H3I EHD3 AK3 HIST1H3B MAFG HIST1H3C MAFF RAD51B HIST1H3D MAFK HIST1H3E LRRC16A H3F3B RAD51C SH2B1 CABLES2 JMJD1C ZFPM2 MICAL1 H3F3A HBD IFNA5 AKAP10 DOCK10 IFNA4 DOCK11 IFNA7 HBE1 IFNA6 HBG2 IFNA1 HBG1 IFNA2 DOCK6 IFNA8 DOCK5 KIF21A DOCK4 KIF21B IFNA13 CDK5 DOCK9 KIFAP3 IFNA14 DOCK8 IFNA16 IFNA17 KIF16B IFNA10 KIF20A KIF20B IFNA21 KLC1 KLC4 KLC3 KLC2 KIF3B KIF3C SIN3A KIF18B KIF4B KIF4A CABLES1 KIF11 WEE1 KIF15 KIF19 CAPZB ABL1 KIF13B KIF1C KIF1B KIF1A CDK2 KIF25 KIF23 KIF22 KIF6 KIF27 HDAC2 DOCK7 KIF9 HDAC1 KIFC2 IFNB1 KIFC1 PRKAR1B PRKAR1A INOSITOL PHOSPHATE METABOLISM%REACTOME%R-HSA-1483249.3 Inositol phosphate metabolism NUDT11 INPPL1 NUDT10 INPP5B PLCG2 INPP5A PPIP5K1 IPMK PPIP5K2 MTMR9 INPP5D PLCD3 INPP5J PLCD4 PLCD1 IPPK OCRL MTMR7 PLCG1 MINPP1 PLCH1 PLCH2 ISYNA1 IMPA1 SYNJ1 IMPA2 INPP1 MIOX ITPK1 PLCE1 ITPKB ITPKC PLCB3 PLCB4 IP6K1 ITPKA NUDT3 PLCB1 NUDT4 IP6K3 PLCB2 IP6K2 PLCZ1 PLD4 PTEN INPP4A INPP4B RUNX2 REGULATES GENES INVOLVED IN CELL MIGRATION%REACTOME DATABASE ID RELEASE 72%8941332 RUNX2 regulates genes involved in cell migration ITGBL1 AKT1 MMP13 AKT2 AKT3 ITGA5 CBFB DIMERIZATION OF PROCASPASE-8%REACTOME%R-HSA-69416.2 Dimerization of procaspase-8 TRADD TNFSF10 FAS TNFRSF10B FASLG RIPK1 TNFRSF10A TRAF2 FADD CASP8 ENTRY OF INFLUENZA VIRION INTO HOST CELL VIA ENDOCYTOSIS%REACTOME DATABASE ID RELEASE 72%168275 Entry of Influenza Virion into Host Cell via Endocytosis CLTA CLTC MITOCHONDRIAL UNCOUPLING%REACTOME DATABASE ID RELEASE 72%166187 Mitochondrial Uncoupling UCP1 SLC25A27 UCP3 UCP2 PM20D1 SLC25A14 RESPIRATORY ELECTRON TRANSPORT%REACTOME%R-HSA-611105.3 Respiratory electron transport UQCR11 NDUFA7 UQCR10 NDUFA6 NDUFA5 NDUFA3 NDUFA2 NDUFA1 ETFDH NDUFAF6 NDUFAF7 NDUFAF4 NDUFAF5 NDUFAF2 NDUFAF3 TMEM126B NDUFAF1 MT-ND6 MT-ND4 MT-ND5 MT-ND2 MT-ND3 MT-ND1 NDUFA4 MT-CO1 UQCRC1 UQCRC2 COX7A2L SCO1 TIMMDC1 SCO2 MT-CO2 MT-CO3 SDHC SDHD SDHA SDHB NDUFB10 NDUFB11 SURF1 ACAD9 COX7B NUBPL ECSIT COX7C COX8A COX5B COX5A CYC1 NDUFV3 NDUFV2 UQCRB NDUFV1 COX6C LRPPRC UQCRH UQCRFS1 TACO1 COX6A1 UQCRQ NDUFS8 NDUFS7 MT-CYB NDUFS6 NDUFS5 NDUFS4 ETFA NDUFS3 ETFB NDUFAB1 COX6B1 NDUFS2 NDUFS1 COX16 COX18 COX11 COX14 NDUFC2 NDUFA13 NDUFC1 NDUFA11 NDUFA12 TRAP1 NDUFA10 COQ10B COQ10A NDUFB9 NDUFB8 NDUFB7 NDUFB6 NDUFB5 NDUFB4 NDUFB3 NDUFB2 NDUFB1 CYCS COX20 COX4I1 NDUFA9 NDUFA8 ABC TRANSPORTER DISORDERS%REACTOME DATABASE ID RELEASE 72%5619084 ABC transporter disorders PSMD3 OS9 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 RNF185 UBA52 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 KCNJ11 PSMB10 PSMA8 PSMB6 PSMB7 ABCD4 PSMB4 PSMB5 PSMB2 UBB PSMB3 UBC PSMB1 PSMF1 RPS27A APOA1 SHFM1 ABCA12 ABCG8 ABCG5 PSMB8 ABCD1 PSMB9 ABCB6 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 ABCC2 ABCC8 ERLIN1 ERLIN2 ABCB4 ABCC6 DERL3 ERLEC1 ABCA3 ABCA1 CFTR PSMD8 VCP PSMD9 ABCB11 PSMD6 ABCC9 PSMD7 SEL1L PSMD4 DERL1 PSMD5 DERL2 PSMD2 RNF5 TRIGLYCERIDE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 72%75109 Triglyceride biosynthesis DGAT1 GPAM AGMO MOGAT3 MOGAT2 MOGAT1 GK2 LPIN1 LPIN2 LPIN3 GPAT2 DGAT2 GK REVERSAL OF ALKYLATION DAMAGE BY DNA DIOXYGENASES%REACTOME DATABASE ID RELEASE 72%73943 Reversal of alkylation damage by DNA dioxygenases ALKBH5 FTO ASCC2 ASCC3 ASCC1 ALKBH3 ALKBH2 EGR2 AND SOX10-MEDIATED INITIATION OF SCHWANN CELL MYELINATION%REACTOME DATABASE ID RELEASE 72%9619665 EGR2 and SOX10-mediated initiation of Schwann cell myelination EGR2 SMARCA4 LAMA2 UTRN SCD5 LAMB1 MBP DAG1 CYP51A1 ADGRV1 MPZ TEAD1 WWTR1 NAB1 POU3F1 PMP22 NAB2 POU3F2 ADGRG6 PRX HMGCR YAP1 SREBF2 SOX10 MAG HDAC2 DRP2 LAMC1 DEFECTIVE SFTPA2 CAUSES IDIOPATHIC PULMONARY FIBROSIS (IPF)%REACTOME%R-HSA-5687868.1 Defective SFTPA2 causes idiopathic pulmonary fibrosis (IPF) SFTPA2 ACYL CHAIN REMODELLING OF PG%REACTOME%R-HSA-1482925.1 Acyl chain remodelling of PG PLA2G4B PLA2G4A LPCAT4 CRLS1 PLA2G10 PLA2G1B PLA2R1 LPGAT1 LPCAT1 PLA2G3 PLA2G2F PLA2G2D PLA2G5 PLA2G2E PLA2G12A PLA2G4F PLA2G2A PLA2G4D RESOLUTION OF D-LOOP STRUCTURES%REACTOME%R-HSA-5693537.1 Resolution of D-Loop Structures EXO1 RTEL1 WRN RMI2 DNA2 SPIDR RMI1 TOP3A EME1 RAD51D EME2 GEN1 BRIP1 SLX1B BARD1 XRCC2 XRCC3 MRE11A SLX1A RAD51AP1 RAD51 RBBP8 ATM BRCA2 PALB2 RAD51B KAT5 RAD50 RAD51C BRCA1 NBN MUS81 BLM SLX4 POST-TRANSCRIPTIONAL SILENCING BY SMALL RNAS%REACTOME%R-HSA-426496.2 Post-transcriptional silencing by small RNAs TNRC6A TNRC6B AGO3 TNRC6C AGO4 AGO1 AGO2 DEFECTIVE CYP19A1 CAUSES AROMATASE EXCESS SYNDROME (AEXS)%REACTOME%R-HSA-5579030.1 Defective CYP19A1 causes Aromatase excess syndrome (AEXS) CYP19A1 SYNTHESIS OF 12-EICOSATETRAENOIC ACID DERIVATIVES%REACTOME DATABASE ID RELEASE 72%2142712 Synthesis of 12-eicosatetraenoic acid derivatives ALOX15 ALOX12 GPX2 GPX1 ALOXE3 GPX4 ALOX12B CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM%REACTOME DATABASE ID RELEASE 72%1793185 Chondroitin sulfate dermatan sulfate metabolism SDC4 SDC2 SDC3 CHST11 CHST12 CSGALNACT1 CHST15 CHST13 CSGALNACT2 IDUA CHSY1 SDC1 CHSY3 XYLT2 XYLT1 CHPF2 HSPG2 ARSB B3GALT6 B4GALT7 HYAL1 CHPF CHST7 HYAL3 B3GAT3 B3GAT2 IDS B3GAT1 GPC1 GPC3 GPC2 BCAN GPC5 VCAN GPC4 DSEL GPC6 NCAN CHST3 UST HEXB DSE BGN HEXA CSPG5 CSPG4 CHST14 DCN AGRN CAP-DEPENDENT TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 72%72737 Cap-dependent Translation Initiation RPL26 RPL29 RPL10L RPS4X RPL10A RPL28 RPS3A RPL23A FAU RPL41 RPL3L RPL10 RPL12 RPL13A RPL11 RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL27A RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS15 RPS14 RPS17 RPS16 RPS19 RPL18A RPL36AL RPS18 RPLP1 RPS11 RPS10 RPLP0 RPS13 RPS12 RPLP2 RPL7A RPS27L PABPC1 UBA52 RPL37A RPS26 RPS25 RPS28 EIF1AX RPS27 EIF2B5 RPL36A EIF2B4 EIF2B3 RPS29 EIF2B2 EIF2S2 RPS20 RPL35A EIF2S1 RPS21 EIF5 RPS24 EIF2S3 RPS23 EIF2B1 EIF5B EIF4A2 EIF4H EIF4A1 EIF3M EIF3K EIF3L RPL22L1 EIF3I EIF3J EIF3G EIF3H EIF3E EIF3F EIF3C EIF3D EIF3A RPS4Y2 EIF3B RPS4Y1 RPS27A EIF4G1 EIF4E RPL26L1 RPL4 RPL39L RPL5 RPL30 RPL3 RPL32 EIF4EBP1 RPL31 EIF4B RPL34 RPL8 RPL9 RPL6 RPL7 RPL36 RPL35 RPL38 RPL37 RPL39 RPS15A RPL21 RPL23 RPL22 RPL24 RPL27 RETROGRADE NEUROTROPHIN SIGNALLING%REACTOME DATABASE ID RELEASE 72%177504 Retrograde neurotrophin signalling SH3GL2 DNM1 DNAL4 DNM3 CLTC DNM2 CLTA AP2A1 AP2B1 AP2A2 AP2S1 AP2M1 NTRK1 NGF INTERACTIONS OF TAT WITH HOST CELLULAR PROTEINS%REACTOME DATABASE ID RELEASE 72%176034 Interactions of Tat with host cellular proteins CDK9 CCNT1 NOTCH4 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME DATABASE ID RELEASE 72%9013700 NOTCH4 Activation and Transmission of Signal to the Nucleus NCSTN ADAM10 APH1B PSENEN YWHAZ DLL4 PSEN2 PSEN1 JAG1 NOTCH4 APH1A DEFECTIVE ALG8 CAUSES ALG8-CDG (CDG-1H)%REACTOME DATABASE ID RELEASE 72%4724325 Defective ALG8 causes ALG8-CDG (CDG-1h) ALG8 DEFECTIVE ALG12 CAUSES ALG12-CDG (CDG-1G)%REACTOME%R-HSA-4720489.1 Defective ALG12 causes ALG12-CDG (CDG-1g) ALG12 SIGNALING BY NOTCH1 IN CANCER%REACTOME DATABASE ID RELEASE 72%2644603 Signaling by NOTCH1 in Cancer CUL1 NCSTN ADAM10 APH1B TBL1X CCNC UBA52 PSENEN TBL1XR1 EP300 ADAM17 UBB UBC RPS27A MYC NOTCH1 MAML2 MAML1 RBPJ HES1 SNW1 MAML3 MAMLD1 NCOR2 CREBBP HDAC11 HEY1 NCOR1 HDAC3 HEY2 HDAC4 HDAC5 DLL1 HDAC10 HDAC9 KAT2B HDAC6 KAT2A HDAC7 DLL4 NEURL1B HES5 JAG2 JAG1 MIB2 MIB1 HDAC8 HEYL NEURL1 HDAC2 SKP1 HDAC1 RBX1 PSEN2 PSEN1 APH1A CDK8 DEFECTIVE GSS CAUSES GLUTATHIONE SYNTHETASE DEFICIENCY (GSS DEFICIENCY)%REACTOME%R-HSA-5579006.1 Defective GSS causes Glutathione synthetase deficiency (GSS deficiency) GSS TRANSCRIPTIONAL REGULATION BY MECP2%REACTOME%R-HSA-8986944.2 Transcriptional Regulation by MECP2 GRIA2 CAMK2D CAMK2A TRPC3 TBL1X CAMK2G HTT CAMK4 TBL1XR1 BDNF GPRIN1 OPRK1 PRKACA GRIN2A SOX2 AURKB HIPK2 GRIN2B GAMT MEF2C MET RBFOX1 LBR SLC2A3 PTPN4 CREB1 SGK1 TNRC6C GPS2 OPRM1 TNRC6A TNRC6B FKBP5 PVALB MOBP PTPN1 IRAK1 SIN3A NCOR2 NCOR1 HDAC3 MOV10 DLL1 AGO3 GAD1 AGO4 DGCR8 CRH AGO1 PPARG GAD2 AGO2 HDAC2 HDAC1 FOXG1 PTEN CAMK2B SST CREB3 FACTORS ACTIVATE GENES%REACTOME DATABASE ID RELEASE 72%8874211 CREB3 factors activate genes MBTPS1 CREB3 CREB3L4 CREB3L1 MBTPS2 CREB3L2 CREB3L3 CREBRF DCSTAMP PRE-NOTCH PROCESSING IN THE ENDOPLASMIC RETICULUM%REACTOME%R-HSA-1912399.2 Pre-NOTCH Processing in the Endoplasmic Reticulum POGLUT1 POFUT1 NOTCH2 NOTCH3 NOTCH4 NOTCH1 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER%REACTOME%R-HSA-76061.2 RNA Polymerase III Transcription Initiation From Type 1 Promoter POLR2E POLR2F POLR2H GTF3C1 GTF3C2 GTF3C3 GTF3C4 POLR2K GTF3C5 POLR2L GTF3C6 BRF1 GTF3A BDP1 TBP CRCP POLR1C POLR3GL POLR3A POLR3B POLR3C POLR3D POLR3E POLR3F POLR3G POLR3H POLR3K IRS-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%R-HSA-2428928.1 IRS-related events triggered by IGF1R PDPK1 IGF2 FRS2 PTPN11 FGF16 TRIB3 FGF7 FGF18 TLR9 GAB1 IGF1 PIK3R1 PIK3R2 FGF6 PIK3CA FGF9 SOS1 FGF20 FGF1 FGF2 FGF23 FGF3 FGF22 PIK3C3 FGF10 FGF4 HRAS PIK3R4 IGF1R KLB IRS4 IRS1 FLT3 NRAS PDE3B IRS2 THEM4 FLT3LG GAB2 FGF19 PIK3CB FGFR4 AKT2 SIGNALING BY MODERATE KINASE ACTIVITY BRAF MUTANTS%REACTOME DATABASE ID RELEASE 72%6802946 Signaling by moderate kinase activity BRAF mutants CAMK2D CAMK2A MAP2K1 MAP2K2 BRAF RAF1 CAMK2G ITGA2B ARAF PEBP1 IQGAP1 ARRB2 JAK2 KSR1 KSR2 APBB1IP CNKSR2 CNKSR1 VCL ARRB1 KRAS PHB RAP1B FGB MARK3 HRAS FGA FN1 VWF RAP1A FGG NRAS ITGB3 YWHAB BRAP SRC MAPK1 CSK MAPK3 TLN1 CAMK2B MAP3K11 SYNTHESIS OF PC%REACTOME%R-HSA-1483191.4 Synthesis of PC CHKB CHKA STARD10 CHPT1 PEMT LPIN1 LPIN2 SLC44A5 LPIN3 ACHE SLC44A3 SLC44A4 SLC44A1 SLC44A2 LPCAT1 PCTP MFSD2A PCYT1B PCYT1A CSNK2A1 STARD7 CSNK2A2 PHOSPHO1 CSNK2B ABHD3 CHAT CEPT1 BCHE INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS%REACTOME%R-HSA-997272.1 Inhibition of voltage gated Ca2+ channels via Gbeta gamma subunits GNG11 GNG13 KCNJ3 KCNJ5 GNB2 KCNJ6 KCNJ10 GNB1 GNB4 KCNJ2 KCNJ9 KCNJ15 GNB3 KCNJ4 KCNJ16 KCNJ12 GNB5 GNGT1 GNGT2 GABBR2 GABBR1 GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 GNG10 GNG12 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%R-HSA-2122947.3 NOTCH1 Intracellular Domain Regulates Transcription MAML2 TLE4 CUL1 MAML1 TLE2 TLE1 TBL1X RBPJ HES1 HIF1A SNW1 MAML3 NBEA CCNC MAMLD1 UBA52 TBL1XR1 CREBBP NCOR2 HDAC11 HDAC3 HEY1 NCOR1 HEY2 HDAC4 HDAC5 EP300 HDAC10 HDAC9 HDAC6 KAT2B HDAC7 KAT2A HES5 UBB HDAC8 UBC HEYL HDAC2 RPS27A HDAC1 SKP1 RBX1 MYC NOTCH1 CDK8 SYNTHESIS OF 5-EICOSATETRAENOIC ACIDS%REACTOME DATABASE ID RELEASE 72%2142688 Synthesis of 5-eicosatetraenoic acids PON2 PON1 LTC4S GPX2 GPX1 GPX4 PON3 ALOX5AP ALOX5 FORMATION OF THE ACTIVE COFACTOR, UDP-GLUCURONATE%REACTOME DATABASE ID RELEASE 72%173599 Formation of the active cofactor, UDP-glucuronate SLC35D1 UGP2 UGDH FORMATION OF TC-NER PRE-INCISION COMPLEX%REACTOME DATABASE ID RELEASE 72%6781823 Formation of TC-NER Pre-Incision Complex AQR POLR2E POLR2F POLR2H ZNF830 POLR2K CCNH POLR2L XPA COPS7B UBA52 COPS7A GTF2H1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 ERCC3 ERCC2 ERCC6 EP300 CUL4A TCEA1 PRPF19 UBB ERCC8 UBC CUL4B RPS27A DDB1 GPS1 USP7 CDK7 POLR2A POLR2B POLR2C POLR2D XAB2 POLR2G MNAT1 POLR2I POLR2J HMGN1 PPIE COPS4 COPS3 COPS6 COPS5 COPS2 UVSSA RBX1 COPS8 ISY1 THE PROTON BUFFERING MODEL%REACTOME DATABASE ID RELEASE 72%167827 The proton buffering model UCP1 SLC25A27 UCP3 UCP2 SLC25A14 RHO GTPASES ACTIVATE KTN1%REACTOME DATABASE ID RELEASE 72%5625970 RHO GTPases activate KTN1 KTN1 KLC1 KLC4 KLC3 CDC42 KLC2 KIF5B KIF5A RHOG RHOA RAC1 RHO GTPASES ACTIVATE ROCKS%REACTOME%R-HSA-5627117.2 RHO GTPases Activate ROCKs PPP1R12A CFL1 MYL12B MYH9 PPP1R12B LIMK2 LIMK1 RHOA MYH11 ROCK1 ROCK2 RHOC RHOB MYH14 MYH10 PPP1CB PAK1 MYL6 MYL9 MEMBRANE TRAFFICKING%REACTOME DATABASE ID RELEASE 72%199991 Membrane Trafficking NBAS RAB1B DCTN4 STX18 KIF3A BNIP1 GALNT2 YWHAG GALNT1 ARCN1 CAPZA3 YWHAH KIF26A KIF26B CAPZA1 CAPZA2 RAB18 RAB3GAP2 COPG2 COPG1 ACTR10 RAB3GAP1 DYNC1LI1 APP TFRC DYNC1LI2 ARF4 SNAP23 ZW10 CTSZ AP4E1 ARRB1 PRKAA2 CLINT1 AP4M1 AP1G2 FTH1 AP3S1 SH3GL2 SH3D19 TPD52 AP3B1 GAK VAMP8 VAMP7 DNAJC6 KIF18A DNASE2 FTL NAPA RAB5C TGOLN2 BLOC1S4 BLOC1S6 SNX2 BLOC1S1 RAB3IP BLOC1S3 DYNLL2 RAB11A CLVS2 STX4 KIF2A SNX9 AP4S1 KIF2C PLA2G6 SNX5 KIF2B TXNDC5 CLVS1 TBC1D8B SNAPIN SORT1 GBF1 DTNBP1 HIP1R DYNC1I1 LNPEP M6PR PUM1 TPD52L1 AVP CENPE AP4B1 IGF2R VAMP3 NECAP1 GOLGB1 CPD YIPF6 CHMP2A ACBD3 PICALM FZD4 PLA2G4A BTC EPGN TGFA AREG HBEGF EREG ARF3 ARF1 AGPAT3 USP6NL SCOC GJA3 GJA5 GJA4 GJA9 GJA8 GJC2 GJB4 F5 GJB3 GJB6 GJB5 GJB7 F8 GJD4 GJD3 TMF1 ARFRP1 RALGAPA2 CD3D RALGAPB RHOBTB3 ARL1 VPS51 VPS53 VPS52 VPS54 GCC2 GCC1 GOLGA1 ARFIP2 C2CD5 STX10 SYS1 ASPSCR1 RABEPK NAA30 TBC1D1 TRAPPC4 TBC1D4 NAA35 NAA38 EGF CBL EGFR SEC23A ITSN2 SCARB2 CHRM2 FNBP1L AGFG1 FNBP1 LRP2 GAPVD1 BIN1 AGTR1 AMPH CFTR CLTCL1 PACSIN2 PACSIN3 KIAA0319 PACSIN1 TOR1A TOR1B SYT8 SNAP91 DAB2 AAK1 IL7R HIP1 STON1 SEC24B STON2 SEC24A SLC2A8 SGIP1 DNM1 EPN2 ANK2 DNM3 CTTN VAMP4 ANK3 FCHO1 FCHO2 REPS2 UBQLN1 REPS1 UBQLN2 SNX18 NECAP2 SEC24D SYT11 SEC24C GJC1 GJA10 SAR1B SEC13 KIF5B PIP5K1C KIF5A EXOC8 EXOC7 SLC2A4 EXOC4 EXOC3 EXOC6 EXOC5 EXOC2 EXOC1 RAB27B SLC18A3 GJD2 MYO5A RAB27A WASL TMED2 RAB6A WNT5A CLTC CLTB CLTA AP2A1 AP2B1 AP2A2 AP2S1 AKT2 AKT3 AP2M1 RAC1 CHML TSG101 VPS4B VPS4A SBF1 MVB12B SBF2 MVB12A VPS36 SYT2 VTA1 SYT9 VPS37C RAB43 VPS37D VPS37A STAM SNF8 VPS37B ADRBK2 CHMP2B CHMP4C UBAP1 RAB32 CHMP4B CHMP3 RAB35 CHMP4A CHMP6 VPS25 RAB38 SH3GL3 STAM2 CHMP7 VPS28 CHMP5 GGA3 RAB21 STXBP3 ARF6 DNM2 RAB12 RAB13 SEC31A RAB39B RAB8B RAB33A INS RAB7B RAB11B RAB9A ITSN1 GRIA1 MYO6 APOB NSF GJA1 GJB2 GJB1 RALA ADRB2 NAPB STX16 GOSR1 GOLIM4 NAPG CYTH3 CYTH2 RAB41 GOLGA4 GOLGA5 GOLGA2 CYTH4 MAN2A2 CUX1 MAN1A2 MAN2A1 MAN1C1 STX6 VTI1A GGA2 GGA1 STX5 MAN1A1 SNAP29 CD3G YKT6 CYTH1 COG8 RIC1 COG7 COG6 COG5 COG4 COG3 ACTR1A COG2 AVPR2 RAB39A COG1 BET1L RAB33B RGP1 GABARAPL2 RAB30 RAB8A RAB36 ALPP TRIP11 VPS45 ULK1 GABARAP MYH9 CSNK1D DYNLL1 MAP1LC3B OPTN PAFAH1B1 DYNC1I2 DCTN2 DCTN3 DYNC1H1 ARPC1A COPS7B COPS7A HGS RAB5A SPTAN1 RAB7A ARPC4 ARPC5 ARPC2 ARPC3 ACTR3 ACTR2 MYO1C TJP1 GNS GPS1 SERPINA1 SPTB SPTBN4 SPTBN5 SPTA1 SPTBN1 SPTBN2 DCTN1 TFG LMAN1L GOSR2 LMAN2L SCFD1 MIA2 PLIN3 MIA3 STX17 USO1 LMAN1 LMAN2 TRAPPC10 SEC23IP LDLR RAB31 COPS4 COPS3 TRAPPC2L COPS6 ARFGAP1 TBC1D20 COPS5 TRAPPC2 ANKRD28 COPS2 TRAPPC3 SEC16B RAB5B SEC16A COPS8 TRAPPC5 PREB TRAPPC9 TRAPPC1 CNIH1 KDELR3 TMEM115 CNIH2 CNIH3 MCFD2 PPP6C PPP6R1 PPP6R3 TRAPPC6A TACR1 TRAPPC6B GORASP1 SEC22A SEC22C FOLR1 BET1 OCRL RAB10 TBC1D10C RAB4A CD4 SYNJ2 SYNJ1 PIK3C2A CTSC PRKAB2 PRKAB1 NEDD8 RAB14 SFN TF RAB9B AP1G1 AP1S2 AP1B1 AP1S1 RACGAP1 AP1S3 AP1M2 AP1M1 CD59 DENND5B RABGEF1 YWHAB RINL CD55 TRAPPC12 PRKAG1 TRAPPC11 CHM DENND5A PRKAG2 SH3KBP1 TRAPPC13 TBC1D10A TBC1D10B SYTL1 PRKAG3 TBC1D24 RAB3A EPS15 TBC1D25 DENND6B SYT1 RIN3 AKT1 GDI1 SH3GL1 DENND6A RIN1 GDI2 EPS15L1 RIN2 TBC1D13 TBC1D14 EPN1 TBC1D17 TBC1D15 YWHAZ TBC1D16 ANKRD27 CCZ1B DENND4B DENND4A HPS1 VAMP2 CCZ1 HPS4 ARRB2 TRAPPC8 MON1A MON1B DENND1C UBA52 DENND1B DENND1A DENND2D DENND2C DENND2A RHOQ RAB3IL1 TBC1D2 TBC1D3 RABEP1 TRIP10 ALS2 TBC1D7 RABGAP1 DENND3 COL7A1 ADRBK1 ALS2CL ST5 DVL2 UBB UBC RPS27A HSPA8 TSC2 TSC1 KDELR1 KIF21A KIF21B KIFAP3 RINT1 KIF16B ANK1 KDELR2 KIF20A KIF20B COPB2 COPA TMED10 COPB1 KLC1 KLC4 KLC3 KLC2 KIF3B KIF3C RAB6B LDLRAP1 SURF4 KIF18B KIF4B KIF4A COPE KIF11 USE1 BICD1 BICD2 KIF15 KIF19 CAPZB KIF13B TMED3 KIF1C KIF1B KIF1A TMED7 TMED9 KIF25 COPZ2 KIF23 KIF22 ARFGAP3 KIF6 KIF27 COPZ1 ARFGAP2 KIF9 YWHAE KIFC2 KIFC1 SEC22B PAFAH1B3 ARF5 PAFAH1B2 YWHAQ DCTN6 RAB1A DCTN5 SIGNALING BY FGFR1 IN DISEASE%REACTOME%R-HSA-5655302.2 Signaling by FGFR1 in disease BAG4 STAT1 ERLIN2 CUX1 FRS2 FGFR1OP GAB1 PIK3R1 TRIM24 FGF6 PIK3CA FGF9 PLCG1 SOS1 FGF20 FGF1 FGF2 FGF23 FGF4 BCR HRAS LRRFIP1 STAT5A STAT5B CPSF6 NRAS ZMYM2 FGFR1OP2 MYO18A FGFR1 GAB2 STAT3 HIV TRANSCRIPTION ELONGATION%REACTOME%R-HSA-167169.2 HIV Transcription Elongation GTF2F1 GTF2F2 CDK7 POLR2A POLR2B TCEB3C POLR2C POLR2D TCEB3B POLR2G POLR2E NELFB MNAT1 POLR2F NELFA NELFCD POLR2H POLR2I POLR2J NELFE POLR2K TCEB3CL2 CCNH POLR2L TCEB3 GTF2H1 TCEB2 GTF2H2 TCEB1 GTF2H3 TCEB3CL GTF2H4 GTF2H5 ERCC3 ERCC2 CDK9 TCEA1 ELL CCNT1 SSRP1 CTDP1 NCBP1 SUPT16H NCBP2 SUPT4H1 SUPT5H DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC%REACTOME DATABASE ID RELEASE 72%3359474 Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC MMACHC FGFR1C LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 72%190373 FGFR1c ligand binding and activation FGF6 FGF9 ANOS1 FGF20 FGF1 FGF2 FGF23 FGF4 GAP JUNCTION DEGRADATION%REACTOME%R-HSA-190873.2 Gap junction degradation CLTB GJA1 CLTA CLTCL1 DNM1 MYO6 AP2M1 DAB2 CLTC DNM2 DEFECTIVE TBXAS1 CAUSES GHOSAL HEMATODIAPHYSEAL DYSPLASIA (GHDD)%REACTOME%R-HSA-5579032.1 Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD) TBXAS1 SIGNALING BY FGFR1%REACTOME%R-HSA-5654736.4 Signaling by FGFR1 PPP2CA PPP2CB BRAF FRS2 PTPN11 SPRY2 FRS3 FGF18 GAB1 PIK3R1 CBL UBA52 FGF6 PIK3CA FGF9 PLCG1 ANOS1 SOS1 PPP2R1A FGF20 FGF1 FGF2 FGF23 FGF3 MKNK1 FGF22 FGF10 FGF4 SPRED2 SPRED1 HRAS FLRT3 FGFRL1 FLRT2 FLRT1 NRAS UBB UBC RPS27A MAPK1 MAPK3 GRB2 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 72%179812 GRB2 events in EGFR signaling HRAS EGFR SOS1 BTC EPGN TGFA NRAS AREG HBEGF EREG EGF RAB GERANYLGERANYLATION%REACTOME%R-HSA-8873719.2 RAB geranylgeranylation RAB1B RAB3B RAB3C RAB43 RAB42 RAB18 RAB2B RABGGTB RABGGTA RAB24 RAB2A RAB32 RAB10 RAB34 RAB35 RAB5A RAB38 RAB7A RAB4A PTP4A2 RAB4B RAB21 RAB20 RAB25 RAB26 RAB23 RAB5C RAB29 RAB15 RAB12 RAB11A RAB13 RAB19 RAB17 RAB41 RAB27B RAB39B RAB22A RAB8B RAB33A RAB27A RAB7B RAB14 RAB9B RAB6B RAB39A RAB33B RAB8A RAB30 RAB36 RAB40A RAB6A RAB3D RAB40B RAB11B RAB40C RAB9A RAB44 RAB31 RAB37 CHM RAB5B RAB3A RAB1A CHML MISCELLANEOUS SUBSTRATES%REACTOME%R-HSA-211958.1 Miscellaneous substrates CYP4A11 CYP4F22 CYP4F2 CYP4F3 CYP3A43 CYP4B1 CYP4A22 CYP2D6 CYP4F11 CYP2W1 CYP2U1 CYP2S1 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS%REACTOME DATABASE ID RELEASE 72%111367 SLBP independent Processing of Histone Pre-mRNAs ZNF473 SNRPG SNRPE SNRPF SNRPB LSM10 LSM11 NCBP1 NCBP2 SNRPD3 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE DURING HIV INFECTION%REACTOME DATABASE ID RELEASE 72%167160 RNA Pol II CTD phosphorylation and interaction with CE during HIV infection GTF2F1 GTF2F2 CDK7 POLR2A POLR2B RNMT POLR2C POLR2D POLR2G POLR2E RNGTT MNAT1 POLR2F POLR2H POLR2I POLR2J POLR2K CCNH POLR2L GTF2H1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 ERCC3 ERCC2 SUPT5H HIV INFECTION%REACTOME DATABASE ID RELEASE 72%162906 HIV Infection TCEB3C TCEB3B TAF9 TAF1L TAF15 TAF12 TAF13 TAF10 TAF11 SSRP1 CTDP1 TAF7 NCBP1 TAF6 NCBP2 TAF5 SUPT4H1 TAF4 SUPT5H LCK TAF3 GTF2F1 TAF2 CD28 GTF2F2 POLR2A POLR2B TAF1 NMT1 POLR2C POLR2D POLR2G NELFB NELFA NELFCD POLR2I POLR2J NELFE PPIA CHMP2A NMT2 PDCD6IP RANBP1 HCK ARF1 FURIN CCNH XRCC6 XRCC4 XRCC5 KPNB1 CDK7 MNAT1 NEDD4L LIG4 TBP FEN1 LIG1 GTF2B GTF2A1 GTF2A2 RNMT GTF2E1 GTF2E2 POLR2E RNGTT POLR2F POLR2H NUP107 NUP188 POLR2K PSIP1 POLR2L BANF1 KPNA1 HMGA1 GTF2H1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 NUP62 NDC1 ERCC3 NUP214 ERCC2 SEC13 CD4 CD8B NUP133 NUP210 DOCK2 NUP93 NUP50 NUP54 CCNK POM121 NUP205 AAAS NUP160 NUP85 TPR NUP88 NUP43 RAE1 RANBP2 ATP6V1H NUP155 NUP153 NUP35 NUPL2 NUP37 AP1G1 PACS1 AP1S2 AP1B1 AP1S1 AP1S3 HLA-A B2M AP2A1 AP1M2 ELL AP2B1 AP1M1 AP2A2 AP2S1 PSMD8 PSMD9 AP2M1 PSMD6 XPO1 PSMD7 PSMD4 RAC1 PSMD5 PSMD2 TAF7L PSMD3 PSMD1 TSG101 VPS4B VPS4A ELMO1 MVB12B PSMA5 MVB12A PSMA6 PSMA3 VTA1 PSMA4 VPS37C PSMA1 VPS37D VPS37A PSMA2 PSME3 TCEB3CL2 PSME4 VPS37B PSME1 CHMP2B PSME2 CCR5 CHMP4C CXCR4 UBAP1 UBA52 TCEB3 CHMP4B CHMP3 TCEB2 CHMP4A PSMD10 TCEB1 CHMP6 PSMB11 TCEB3CL PSMD12 TAF9B PSMD11 CHMP7 VPS28 PSMD14 CHMP5 FYN NPM1 PSMD13 PSMA7 PAK2 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 TCEA1 PSMB2 UBB PSMB3 UBC PSMB1 PSMF1 CCNT2 CCNT1 RPS27A SHFM1 PSMB8 PSMB9 PSMC5 PSMC6 SUPT16H PSMC3 PSMC4 PSMC1 PSMC2 RANGAP1 RCC1 AK6 RAN SLC25A5 CDK9 SLC25A4 SLC25A6 TAF4B BTRC SKP1 CUL5 RBX1 SIGNALING BY NTRK3 (TRKC)%REACTOME DATABASE ID RELEASE 72%9034015 Signaling by NTRK3 (TRKC) HRAS PTPRO NELFB IRS1 NRAS PTPRS PIK3R1 PIK3CA PLCG1 SOS1 NTF3 SRC BAX NTRK3 CRMPS IN SEMA3A SIGNALING%REACTOME%R-HSA-399956.1 CRMPs in Sema3A signaling DPYSL2 DPYSL3 CRMP1 NRP1 CDK5 GSK3B CDK5R1 PLXNA2 PLXNA1 PLXNA3 SEMA3A FES PLXNA4 FYN DPYSL4 DPYSL5 MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 72%397014 Muscle contraction CAMK2D CAMK2A CACNG8 CACNG2 CAMK2G CACNG3 CACNG4 TRIM72 ITGB5 LMOD1 DYSF MYL6B ACTG2 MYL12A MYL12B MYLK CALD1 ANXA6 MYL10 MYH11 ANXA1 CAV3 TPM4 ANXA2 TPM3 TPM2 TPM1 ITGA1 SORBS1 SORBS3 ACTA2 MYLPF MYL5 MYL6 MYL7 MYL9 CACNA1D CACNA1C CACNB2 CACNB3 AKAP9 KCNJ11 VIM DMD TTN TNNI1 TNNI2 TMOD1 MYBPC3 MYBPC1 MYBPC2 ACTN3 TMOD4 TMOD3 TNNC1 TMOD2 TNNC2 NEB MYL4 KAT2B DES MYH3 TNNT1 MYL1 TNNT2 MYL2 TNNT3 MYL3 MYH8 TCAP MYH6 TLN1 ACTN2 CACNA2D2 PRKACA SLC8A1 SLC8A2 NPPC SLN SCN11A NPPA SCN9A SCN1B SCN1A KCNH2 KCNK10 CACNA2D1 KCNK12 KCNK13 CACNA2D3 KCNK15 ATP1B3 KCNK16 ATP1B2 KCNK17 CACNA2D4 ATP1B1 KCNK18 CACNB1 SCN10A CACNB4 STIM1 KCNQ1 SCN8A ORAI2 ORAI1 KCNE1 KCNE2 KCNE3 KCNE4 NPR1 KCNE5 NPR2 GATA4 CACNA1F CACNA1S SCN3B NKX2-5 SCN3A WWTR1 DMPK GUCY1A3 GUCY1B3 FGF14 FXYD4 GUCY1A2 FXYD3 FXYD2 FXYD1 FXYD7 FXYD6 SCN2A FGF13 FGF12 FGF11 SCN2B KCNK5 RYR1 KCNK6 RYR2 AHCYL1 KCNK7 KCNK9 ATP2A3 ATP2A2 ATP2A1 RYR3 SCN5A NOS1 CLIC2 KCND1 KCND2 KCND3 TRPC1 ABCC9 TRDN ASPH SCN4A SCN4B ATP1A4 ATP1A3 ATP1A2 ATP1A1 SRI CACNG6 CACNG7 PLN SCN7A TNNI3 KCNJ2 CORIN KCNJ4 KCNIP1 KCNJ12 KCNIP2 KCNIP3 KCNJ14 KCNIP4 PXN ATP2B4 ITPR1 ATP2B3 ITPR2 ATP2B2 ITPR3 ATP2B1 TBX5 SLC8A3 PAK1 FKBP1B RANGRF KCNK1 KCNK2 KCNK3 VCL KCNK4 PAK2 HIPK1 HIPK2 CAMK2B SYNTHESIS OF PE%REACTOME DATABASE ID RELEASE 72%1483213 Synthesis of PE ETNPPL CHKB PISD CHKA ETNK2 ETNK1 EPT1 PHOSPHO1 LPIN1 LPIN2 LPIN3 CEPT1 PCYT2 SIGNALING BY FGFR3 FUSIONS IN CANCER%REACTOME%R-HSA-8853334.2 Signaling by FGFR3 fusions in cancer GAB1 PIK3R1 HRAS PIK3CA FRS2 SOS1 FGFR3 NRAS TRNA MODIFICATION IN THE NUCLEUS AND CYTOSOL%REACTOME%R-HSA-6782315.5 tRNA modification in the nucleus and cytosol URM1 TRMT13 TRMT11 TRMT10A DUS2 ADAT1 CTU2 TRMT1 CTU1 ADAT2 TRMT6 THG1L FTSJ1 PUS3 CDKAL1 THADA PUS7 WDR4 QTRT1 LAGE3 ALKBH8 TPRKB QTRTD1 TRIT1 KIAA1456 TRMT61A TP53RK EPRS TRDMT1 TRMT44 TRMT112 TYW5 METTL1 TRMT5 TYW3 TYW1 NSUN2 OSGEP TRMT12 LCMT2 NSUN6 RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF MYELOID CELLS%REACTOME%R-HSA-8939246.1 RUNX1 regulates transcription of genes involved in differentiation of myeloid cells LGALS3 CSF2 CBFB CREBBP PRKCB RUNX1 PARASITE INFECTION%REACTOME%R-HSA-9664407.1 Parasite infection VAV1 WIPF1 VAV2 WIPF2 FGR WIPF3 ELMO1 ELMO2 CRK DOCK1 ARPC1B ARPC1A WAS MYO9B ACTG1 ACTB NCKIPSD CDC42 ARPC4 NCKAP1L ARPC5 FYN ARPC2 IGHG4 WASF1 ARPC3 WASF2 IGHG1 ACTR3 IGHG2 ACTR2 WASF3 IGKV1-12 MYH2 MYO10 MYO1C BAIAP2 PTK2 ABI2 ABI1 IGKV2D-28 IGKV4-1 IGKV2D-30 MAPK1 MAPK3 IGKV3-11 LYN YES1 MYO5A WASL CD3G FCGR3A IGKV2-28 SYK IGKV3D-20 HCK ABL1 MYH9 CYFIP2 CYFIP1 NCKAP1 BRK1 BTK IGKV5-2 RAC1 NCK1 VAV3 SIGNALING DOWNSTREAM OF RAS MUTANTS%REACTOME DATABASE ID RELEASE 72%9649948 Signaling downstream of RAS mutants CAMK2D CAMK2A MAP2K1 MAP2K2 BRAF RAF1 CAMK2G ITGA2B ARAF PEBP1 IQGAP1 ARRB2 JAK2 KSR1 KSR2 APBB1IP CNKSR2 CNKSR1 VCL ARRB1 KRAS PHB RAP1B FGB MARK3 HRAS FGA FN1 VWF RAP1A FGG NRAS ITGB3 YWHAB BRAP SRC MAPK1 CSK MAPK3 TLN1 CAMK2B MAP3K11 REGULATION OF APOPTOSIS%REACTOME%R-HSA-169911.2 Regulation of Apoptosis PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 ARHGAP10 UBA52 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PAK2 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 UBB PSMB3 UBC PSMB1 PSMF1 RPS27A SHFM1 PSMB8 PSMB9 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 OMA1 OPA1 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 DEFECTIVE MPI CAUSES MPI-CDG (CDG-1B)%REACTOME%R-HSA-4043916.1 Defective MPI causes MPI-CDG (CDG-1b) MPI TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS%REACTOME DATABASE ID RELEASE 72%159234 Transport of Mature mRNAs Derived from Intronless Transcripts NUP85 TPR EIF4E NUP88 NUP43 RAE1 RANBP2 NUP107 NUP155 NUP188 CPSF4 CPSF1 NUP153 SLBP CPSF3 CPSF2 WDR33 NUP62 FIP1L1 NUP35 NUPL2 NXF1 NDC1 NUP214 SEC13 NUP37 SYMPK NUP133 NUP210 NUP93 NUP50 NUP54 POM121 NUP205 NCBP1 NCBP2 AAAS NUP160 DEFECTIVE GALE CAN CAUSE EPIMERASE-DEFICIENCY GALACTOSEMIA (EDG)%REACTOME DATABASE ID RELEASE 72%5609977 Defective GALE can cause Epimerase-deficiency galactosemia (EDG) GALE GAB1 SIGNALOSOME%REACTOME%R-HSA-180292.3 GAB1 signalosome PAG1 PTPN11 BTC EPGN TGFA AREG HBEGF EREG EGF PXN GAB1 PIK3R1 EGFR PIK3CA SRC CSK SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR3%REACTOME DATABASE ID RELEASE 72%1839130 Signaling by activated point mutants of FGFR3 FGF9 FGF20 FGF16 FGF1 FGFR3 FGF2 FGF18 FGF23 FGF4 ATF4 ACTIVATES GENES IN RESPONSE TO ENDOPLASMIC RETICULUM STRESS%REACTOME%R-HSA-380994.2 ATF4 activates genes in response to endoplasmic reticulum stress DIS3 CXCL8 NFYA NFYB NFYC HERPUD1 DCP2 CEBPB CEBPG PARN CCL2 EXOSC7 EXOSC6 ATF3 EXOSC5 EXOSC4 DDIT3 ATF6 EXOSC9 EXOSC8 ATF4 EXOSC3 IGFBP1 EXOSC2 EXOSC1 ASNS KHSRP MITOTIC PROMETAPHASE%REACTOME DATABASE ID RELEASE 72%68877 Mitotic Prometaphase PRKAR2B PPP1CC YWHAG NUP107 PPP2R5C ERCC6L ZWILCH OFD1 BUB1B CASC5 SMC3 CDC20 PPP2R1B PPP2R1A KNTC1 DYNC1LI1 BIRC5 DYNC1LI2 PRKACA CLIP1 ZW10 MAD1L1 CDCA5 CSNK2A1 CDCA8 SEC13 PDS5B PDS5A CSNK2A2 PMF1 NUP133 SKA1 AURKB SKA2 DSN1 RAD21 PPP2R5D RCC2 NDC80 ZWINT STAG1 KIF18A CSNK2B STAG2 SGOL2 SGOL1 NUF2 WAPAL SPDL1 NDEL1 NUDC SMC1A DYNLL2 KIF2A INCENP KIF2C KIF2B ITGB3BP MIS12 CENPA NSL1 NUP160 CENPC PPP2CA BUB3 PPP2CB BUB1 NUP85 DYNC1I1 CLASP2 CENPT CENPU NUP43 CENPE CENPF CENPH CENPI TAOK1 RANBP2 CENPK CENPL CENPM CENPN B9D2 CENPO CENPP CENPQ CEP57 SPC24 CETN2 MAD2L1 CEP164 SPC25 CCP110 ACTR1A PCM1 CNTRL CEP250 NEK2 NINL CEP290 NUP37 CDK5RAP2 CEP135 TUBB CEP131 TUBGCP2 HAUS4 TUBGCP5 HAUS3 TUBGCP6 HAUS6 CSNK1D TUBGCP3 TUBGCP4 HAUS5 CSNK1E TUBG2 TUBG1 DYNLL1 MZT2B CKAP5 MZT2A HAUS2 NME7 HAUS1 AKAP9 CEP63 MAPRE1 MZT1 SFI1 PAFAH1B1 SDCCAG8 XPO1 DYNC1I2 DCTN2 SSNA1 DCTN3 CCNB2 PPP2R5E HAUS8 HAUS7 CEP70 CEP72 CEP192 PPP2R5B PCNT CEP76 PPP2R5A CLASP1 CEP78 PLK4 DYNC1H1 ODF2 CEP152 NDE1 NEDD1 NEK9 FGFR1OP NEK6 CEP41 NEK7 SMC4 SMC2 EML4 NCAPG NCAPH RPS27 NCAPD2 NUMA1 PLK1 CENPJ CCNB1 CDK1 TUBA4A APITD1 AHCTF1 RANGAP1 TUBA1A HSP90AA1 YWHAE TUBB4B TUBB4A VITAMIN D (CALCIFEROL) METABOLISM%REACTOME DATABASE ID RELEASE 72%196791 Vitamin D (calciferol) metabolism CYP24A1 SUMO2 VDR CYP2R1 GC LGMN UBE2I CUBN CYP27B1 LRP2 PIAS4 ATTACHMENT OF GPI ANCHOR TO UPAR%REACTOME%R-HSA-162791.2 Attachment of GPI anchor to uPAR PIGS PIGU PIGT PGAP1 PLAUR PIGK GPAA1 RNA POLYMERASE I PROMOTER OPENING%REACTOME DATABASE ID RELEASE 72%73728 RNA Polymerase I Promoter Opening MBD2 HIST1H2AE HIST1H2AD HIST3H2BB HIST1H2AC HIST1H2AB HIST1H2AJ HIST2H3A HIST1H2BF HIST1H2BE HIST1H2BH HIST1H2BG HIST2H3D HIST1H2BB HIST1H2BA HIST2H3C HIST1H2BD HIST1H2BC H2AFB1 HIST1H3J HIST1H3A HIST1H3F HIST1H3G HIST1H3H HIST1H3I HIST1H3B HIST1H3C HIST1H3D HIST1H3E H3F3B HIST1H4K HIST1H4L H3F3A MAPK3 H2BFS HIST1H4A HIST1H4B HIST1H4H HIST1H4I HIST1H4J HIST1H4C HIST1H4D HIST1H4E HIST1H4F HIST2H2AA3 HIST2H2AA4 HIST2H2AC H2AFJ UBTF H2AFZ H2AFX H2AFV HIST2H2BE HIST4H4 HIST1H2BN HIST1H2BM HIST1H2BO HIST1H2BJ HIST1H2BI HIST1H2BL HIST1H2BK HIST2H4A HIST2H4B FUSION OF THE INFLUENZA VIRION TO THE HOST CELL ENDOSOME%REACTOME%R-HSA-168288.3 Fusion of the Influenza Virion to the Host Cell Endosome SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER%REACTOME%R-HSA-2894858.1 Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer CUL1 NCSTN ADAM10 APH1B TBL1X CCNC UBA52 PSENEN TBL1XR1 EP300 ADAM17 UBB UBC RPS27A MYC NOTCH1 MAML2 MAML1 RBPJ HES1 SNW1 MAML3 MAMLD1 NCOR2 CREBBP HDAC11 HEY1 NCOR1 HDAC3 HEY2 HDAC4 HDAC5 DLL1 HDAC10 HDAC9 KAT2B HDAC6 KAT2A HDAC7 DLL4 NEURL1B HES5 JAG2 JAG1 MIB2 MIB1 HDAC8 HEYL NEURL1 HDAC2 SKP1 HDAC1 RBX1 PSEN2 PSEN1 APH1A CDK8 RELAXIN RECEPTORS%REACTOME DATABASE ID RELEASE 72%444821 Relaxin receptors RXFP4 RXFP3 INSL3 RLN2 RLN3 RXFP1 RXFP2 INSL5 E2F-ENABLED INHIBITION OF PRE-REPLICATION COMPLEX FORMATION%REACTOME DATABASE ID RELEASE 72%113507 E2F-enabled inhibition of pre-replication complex formation ORC4 ORC6 CDK1 ORC1 ORC3 ORC2 CCNB1 MCM8 ORC5 ESTROGEN-STIMULATED SIGNALING THROUGH PRKCZ%REACTOME%R-HSA-9634635.2 Estrogen-stimulated signaling through PRKCZ PDPK1 HRAS PRKCZ NRAS MAPK1 N-GLYCAN ANTENNAE ELONGATION%REACTOME%R-HSA-975577.1 N-Glycan antennae elongation ST3GAL4 ST8SIA6 ST6GAL1 B4GALT2 B4GALT3 ST8SIA2 B4GALT6 B4GALT1 ST8SIA3 MGAT4C MGAT5 MGAT4A B4GALT4 MGAT4B B4GALT5 PLATELET SENSITIZATION BY LDL%REACTOME DATABASE ID RELEASE 72%432142 Platelet sensitization by LDL PPP2CA PPP2CB PLA2G4A PPP2R5B MAPK14 PPP2R5A PPP2R5D FGR PTPN11 APOB PPP2R5C PTPN6 LRP8 PPP2R1B PPP2R1A PPP2R5E IKBA VARIANT LEADS TO EDA-ID%REACTOME DATABASE ID RELEASE 72%5603029 IkBA variant leads to EDA-ID NFKB1 IKBKB NFKB2 CHUK NFKBIA IKBKG RELA DEFECTIVE POMT2 CAUSES MDDGA2, MDDGB2 AND MDDGC2%REACTOME DATABASE ID RELEASE 72%5083629 Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2 POMT1 POMT2 DAG1 VEGF BINDS TO VEGFR LEADING TO RECEPTOR DIMERIZATION%REACTOME DATABASE ID RELEASE 72%195399 VEGF binds to VEGFR leading to receptor dimerization FIGF FLT1 VEGFB VEGFC PGF VEGFA KDR FLT4 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT%REACTOME%R-HSA-159231.2 Transport of Mature mRNA Derived from an Intronless Transcript NUP85 TPR EIF4E NUP88 NUP43 RAE1 RANBP2 NUP107 NUP155 NUP188 CPSF4 CPSF1 NUP153 CPSF3 CPSF2 WDR33 NUP62 FIP1L1 NUP35 NUPL2 NXF1 NDC1 NUP214 SEC13 NUP37 SYMPK NUP133 NUP210 NUP93 NUP50 NUP54 POM121 NUP205 NCBP1 NCBP2 AAAS NUP160 SIGNALING BY WNT%REACTOME%R-HSA-195721.5 Signaling by WNT CUL1 CAMK2A MEN1 PRKCG PPP2R5C WNT10B WNT10A CSNK2A1 CSNK1A1 CSNK2A2 CTBP1 PLCB3 CSNK2B XIAP PLCB1 PLCB2 TNRC6C PPP3R1 TNRC6A TNRC6B PORCN RNF43 WNT3A FZD4 FZD6 LRP5 FZD8 LRP6 CUL3 CSNK1E VPS29 WNT2B VPS26A VPS35 TMED5 WLS WNT16 HIST1H2AE DVL1 HIST1H2AD HIST3H2BB DVL3 HIST1H2AC HIST1H2AB HIST1H2AJ HIST2H3A SOX2 HIST1H2BF SOX3 HIST1H2BE FRAT1 GNAT2 HIST1H2BH FRAT2 HIST1H2BG SOX17 HIST2H3D SOX9 HIST1H2BB SOX6 HIST1H2BA SOX7 HIST2H3C SOX4 HIST1H2BD SOX13 HIST1H2BC DKK1 H2AFB1 DKK2 DKK4 HIST1H3J SFRP1 SFRP2 HIST1H3A HECW1 HIST1H3F HIST1H3G CCDC88C HIST1H3H RSPO2 HIST1H3I RSPO3 RSPO1 HIST1H3B RSPO4 HIST1H3C KREMEN1 HIST1H3D KREMEN2 HIST1H3E WNT9A H3F3B WNT8A MYC GNG10 HIST1H4K WNT8B WIF1 HIST1H4L LEO1 H3F3A LGR6 LGR5 GNG12 LGR4 H2BFS GNG11 HIST1H4A TLE4 GNG13 TLE3 HIST1H4B TLE2 GNAO1 HIST1H4H TLE1 HIST1H4I CTNNBIP1 GNB2 HIST1H4J PYGO1 HIST1H4C PYGO2 GNB1 TCF7 GNB4 HIST1H4D KLHL12 HIST1H4E WNT1 GNB3 WNT3 WNT4 HIST1H4F BCL9L GNB5 HIST2H2AA3 BCL9 GSK3B CHD8 HIST2H2AA4 USP34 GNGT1 RUVBL1 CBY1 CDC73 SOST HIST2H2AC GNGT2 DACT1 AXIN2 LEF1 ZNRF3 H2AFJ SRY TCF7L1 H2AFZ H2AFX H2AFV PPP3CA SMURF1 RUNX3 PPP3CB HIST2H2BE TRRAP NFATC1 GNG3 RHOA HIST4H4 GNG2 GNG5 GNG4 PARD6A GNG7 GNG8 HIST1H2BN HIST1H2BM HIST1H2BO HIST1H2BJ HDAC1 HIST1H2BI HIST1H2BL HIST1H2BK HIST2H4A HIST2H4B SMARCA4 ASH2L CSNK1G2 PPP2R1B WNT5B PPP2R1A DAAM1 PFN1 TERT WNT11 PPP2R5D PIP5K1B PRKG2 HIST3H3 TNKS NLK TNKS2 PRKG1 RNF146 KAT5 SNX3 PDE6G PPP2CA PPP2CB PDE6B KMT2D PDE6A TCF7L2 CREBBP MOV10 AGO3 AGO4 AGO1 AGO2 FZD2 FZD5 WNT5A CLTC CLTB CLTA RBBP5 AP2A1 AP2B1 AP2A2 AP2S1 AKT2 ROR1 PSMD8 ROR2 PSMD9 AP2M1 PSMD6 XPO1 PSMD7 PSMD4 RAC1 AMER1 PSMD5 AXIN1 PSMD2 PRKCB PPP2R5E PSMD3 AKT1 PSMD1 PPP2R5B PPP2R5A PRKCA YWHAZ RAC2 PSMA5 RAC3 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 ARRB2 PSME4 PSME1 PSME2 ITPR1 ITPR2 UBA52 ITPR3 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 APC PSMA7 PSMB10 SCRIB PSMA8 PRICKLE1 DVL2 FZD1 PSMB6 EP300 CAV1 FZD3 PSMB7 SMURF2 FZD7 VANGL2 PSMB4 PSMB5 PSMB2 CTBP2 UBB AES PSMB3 CTNNB1 UBC PSMB1 PSMF1 WNT9B RPS27A WNT7B WNT7A SHFM1 PSMB8 PSMB9 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 ZRANB1 BTRC SKP1 WNT6 RBX1 WNT2 MAP3K7 USP8 PTK6 REGULATES RHO GTPASES, RAS GTPASE AND MAP KINASES%REACTOME DATABASE ID RELEASE 72%8849471 PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases ARHGAP35 HRAS RASA1 ELMO1 ELMO2 CRK RHOA DOCK1 NRAS BCAR1 PXN PTK6 RAC1 ACTIVATION OF ANTERIOR HOX GENES IN HINDBRAIN DEVELOPMENT DURING EARLY EMBRYOGENESIS%REACTOME%R-HSA-5617472.2 Activation of anterior HOX genes in hindbrain development during early embryogenesis CTCF RBBP4 PAGR1 RARA RARB MEIS1 ZNF335 POLR2E POLR2F POLR2H ASH2L RBBP7 POLR2K POLR2L SUZ12 PCGF2 PAX6 RQCD1 POLR2A POLR2B KMT2D POLR2C POLR2D POLR2G KMT2C POLR2I POLR2J JUN CREBBP NCOA6 WDR5 NCOA3 KDM6A RXRA RBBP5 AJUBA PAXIP1 HIST1H2AE HIST1H2AD HIST3H2BB HIST1H2AC HIST1H2AB HIST1H2AJ HIST2H3A HIST1H2BF HIST1H2BE HIST1H2BH EP300 HIST1H2BG HIST2H3D HIST1H2BB HIST1H2BA HIST2H3C HIST1H2BD HIST1H2BC H2AFB1 HIST1H3J HIST1H3A HIST1H3F HIST1H3G HIST1H3H HIST1H3I HIST1H3B HIST1H3C HIST1H3D HIST1H3E H3F3B HIST1H4K HIST1H4L H3F3A H2BFS EGR2 HIST1H4A HIST1H4B HIST1H4H HIST1H4I HIST1H4J HIST1H4C HIST1H4D HIST1H4E EZH2 HIST1H4F YY1 HIST2H2AA3 HIST2H2AA4 HIST2H2AC H2AFJ EED H2AFZ H2AFX CNOT6 NCOR1 HDAC3 H2AFV HIST2H2BE HIST4H4 HOXA3 HOXA2 HOXA1 HIST1H2BN PKNOX1 HIST1H2BM HOXA4 PIAS2 HIST1H2BO HOXB4 HIST1H2BJ HOXB3 HOXB2 HOXB1 HIST1H2BI HOXD1 HIST1H2BL HOXC4 HIST1H2BK PBX1 MAFB HIST2H4A HOXD4 HOXD3 HIST2H4B RARG RUNX1 REGULATES EXPRESSION OF COMPONENTS OF TIGHT JUNCTIONS%REACTOME%R-HSA-8935964.1 RUNX1 regulates expression of components of tight junctions CLDN5 TJP1 OCLN CBFB RUNX1 GAMMA-GLUTAMYL CYCLE FOR THE BIOSYNTHESIS AND DEGRADATION OF GLUTATHIONE, INCLUDING DISEASES%WIKIPATHWAYS_20200510%WP4518%HOMO SAPIENS Gamma-Glutamyl Cycle for the biosynthesis and degradation of glutathione, including diseases GGT2 GGTLC3 GGTLC2 GGCT GGTLC1 GCLC GSS DPEP1 GGT1 OPLAH MICRORNA FOR TARGETING CANCER GROWTH AND VASCULARIZATION IN GLIOBLASTOMA%WIKIPATHWAYS_20200510%WP3593%HOMO SAPIENS MicroRNA for Targeting Cancer Growth and Vascularization in Glioblastoma HIF1AN MIR31 HIF1A VEGFA HEY1 VEGFB VEGFC HES1 VITAMIN D IN INFLAMMATORY DISEASES%WIKIPATHWAYS_20200510%WP4482%HOMO SAPIENS Vitamin D in inflammatory diseases MAP2K6 MAP2K3 SMAD4 MAP3K1 SMAD3 CHUK VDR DUSP1 NFATC1 MAPK14 NR3C1 TNF RELA NFKB1 IKBKB NFKBIA PPP3CA MED14 PPP3R1 IL6 RXRA IKBKG NANOPARTICLE-MEDIATED ACTIVATION OF RECEPTOR SIGNALING%WIKIPATHWAYS_20200510%WP2643%HOMO SAPIENS Nanoparticle-mediated activation of receptor signaling ITGB1 SRC PXN PIK3CD AREG EGFR MAPK9 MAPK8 NRAS AKT3 MAPK1 HRAS MAP2K1 MAP2K2 ITGA1 FN1 PTK2 MAPK12 MAPK13 COL1A1 MAPK10 MAPK11 KRAS GRB2 MIR6852 SOS1 RAF1 TLN1 MAPK14 INFLUENZA A VIRUS INFECTION%WIKIPATHWAYS_20200510%WP1438%HOMO SAPIENS Influenza A virus infection BCL2 HORMONAL CONTROL OF PUBERTAL GROWTH SPURT%WIKIPATHWAYS_20200510%WP4194%HOMO SAPIENS Hormonal control of Pubertal Growth Spurt SST GNRH1 CANCER IMMUNOTHERAPY BY CTLA4 BLOCKADE%WIKIPATHWAYS_20200510%WP4582%HOMO SAPIENS Cancer immunotherapy by CTLA4 blockade HLA-DRB1 CD86 CD80 PIK3R3 PTPN11 PIK3R2 PIK3R1 PIK3CD PIK3CB PPP2CA PIK3CA CD28 CTLA4 PTPN6 TCA CYCLE NUTRIENT UTILIZATION AND INVASIVENESS OF OVARIAN CANCER%WIKIPATHWAYS_20200510%WP2868%HOMO SAPIENS TCA Cycle Nutrient Utilization and Invasiveness of Ovarian Cancer MAPK1 STAT3 MAPK3 EGFR JAK1 NON-SMALL CELL LUNG CANCER%WIKIPATHWAYS_20200510%WP4255%HOMO SAPIENS Non-small cell lung cancer RB1 ALK CDKN1A ARAF CASP9 RASSF1 CASP8 CCND1 AKT2 RASSF5 CASP3 AKT1 POLK JAK3 PDK1 PRKCG PRKCB PRKCA DDB2 EML4 RARB SOS2 TP53 CRABP2 CRABP1 TGFA PIK3CD FOXO3 STK4 FHIT EGFR RXRB ERBB2 NRAS E2F1 AKT3 PLCG2 E2F2 MAPK1 HRAS E2F3 MAP2K1 BAK1 MAP2K2 PLCG1 BID RXRG STAT5A STAT5B GADD45B GADD45A BAD CDKN2A EGF KRAS BRAF GRB2 GADD45G SOS1 CDK6 RAF1 CDK4 BAX CYCS PIK3R3 PIK3R2 PIK3R1 PIK3CB PIK3CA STAT3 MAPK3 RXRA 22Q11.2 DELETION SYNDROME%WIKIPATHWAYS_20200510%WP4657%HOMO SAPIENS 22q11.2 Deletion Syndrome SNAP29 LINC00896 DGCR2 VWF GP1BB TANGO2 PAX3 GP1BA C22orf39 SEPT5 ACTA2 SLC7A4 HIC2 CLDN5 CYP26C1 THAP7 ALDH1A2 HAND2 GNB1L TSSK2 ASF1A RTN4R FOXC2 FOXC1 OAT DGCR14 SRF MIR3198-2 CHRD EGFR TRMT2A CDC42 HIRA ARVCF CDC45 HIRIP3 GBX2 CLTCL1 DROSHA MIR4761 SHOC2 DRD2 NKX2-5 PRODH TBX1 RANBP1 CBX5 SERPIND1 TXNRD2 KLHL22 RAF1 MIR3618 GP5 ALDH4A1 CYP26A1 GP9 GLUD1 P2RX6 ACTC1 MIR6816 ZNF74 PI4KA LZTR1 FGFR2 FGF10 FGFR1 FOXA2 HES1 SLC25A1 UFD1L TSKS LRRC74B EMC10 SLC2A4 ZDHHC8 COMT C22orf29 MED15 CRKL PPP1CB SHH AIFM3 CYP26B1 FGF8 MRPL40 DGCR8 DGCR6L GSC2 DGCR6 SCARF2 PITX2 VITAMINS A AND D - ACTION MECHANISMS%WIKIPATHWAYS_20200510%WP4342%HOMO SAPIENS Vitamins A and D - action mechanisms VDR RARA RXRA OXIDATIVE STRESS%WIKIPATHWAYS_20200510%WP408%HOMO SAPIENS Oxidative Stress GCLC NFIX MAOA MGST1 GSTT2 MT1X TXN2 HMOX1 XDH JUNB MAPK10 UGT1A6 NQO1 GPX1 GPX3 TXNRD2 TXNRD1 GSR CYBB FOS MAPK14 SOD2 SOD3 SOD1 NFKB1 SP1 CAT CYP1A1 NOX3 NOX4 NOX5 NOX1 NFE2L2 COMMON PATHWAYS UNDERLYING DRUG ADDICTION%WIKIPATHWAYS_20200510%WP2636%HOMO SAPIENS Common Pathways Underlying Drug Addiction ARAF PRKCG PRKCB PRKCA GRIA1 GRIA2 CAMK2A ADCY1 ADCY8 ACTG2 GRM1 MAPK1 GNAI1 ACTB MAP2K1 ACTG1 MAP2K2 RAP1B PPP1CC GRM5 GRIN2A DRD2 RAP1A PRKACG DRD1 PRKACA PRKACB GRIA3 DRD4 GRIA4 PPP1CA RAF1 GRIN1 GJB1 PPP1CB CREB1 PPP1R1A CAMK4 GNAS CALM3 CALM1 CALM2 MAPK3 ANGIOGENESIS%WIKIPATHWAYS_20200510%WP1539%HOMO SAPIENS Angiogenesis ANGPT1 NOS3 MAPK1 PDGFB HIF1A ARNT VEGFA MMP9 PLCG1 FGF2 TIMP2 PTK2 KDR TIMP3 TEK AKT1 MAPK14 SRC PDGFRA PIK3CA SMAD1 FGFR2 CREBBP FLT1 NICOTINE ACTIVITY ON DOPAMINERGIC NEURONS%WIKIPATHWAYS_20200510%WP1602%HOMO SAPIENS Nicotine Activity on Dopaminergic Neurons GNG2 TH GNAI1 CDK5 GNB1 PPP1R1B DRD3 SLC18A2 KCNK3 DRD2 PRKACA DRD4 PPP1CA CHRNB2 DDC CHRNA3 CHRNA5 KCNK9 CHRNA4 CHRNA6 ADCY2 ENDOTHELIN PATHWAYS%WIKIPATHWAYS_20200510%WP2197%HOMO SAPIENS Endothelin Pathways PRKCA GUCY1B2 CALCA CALCRL ATP2A2 ADRB1 ECE1 ADRA1A MYLK CNN1 EDNRA MAPK1 NOS3 GNAI1 GNA15 EDNRB MAP2K1 NPY PTGIR EDN1 CAD NPY1R RIIAD1 GNG13 ADCY10 MYL1 MT-CO2 GNB5 PLCB1 RAMP1 RAF1 GNAS CALM3 CALM1 CALM2 PURINE METABOLISM AND RELATED DISORDERS%WIKIPATHWAYS_20200510%WP4224%HOMO SAPIENS Purine metabolism and related disorders GRM5 PRPS1 XDH ADSL TPMT AMPD1 PAICS PFAS APRT DGUOK ATIC PNP MAT2A RRM2B IMPDH1 PPAT AOX1 HPRT1 GART ADSS ITPA ADA EV RELEASE FROM CARDIAC CELLS AND THEIR FUNCTIONAL EFFECTS%WIKIPATHWAYS_20200510%WP3297%HOMO SAPIENS EV release from cardiac cells and their functional effects MIR126 CXCL12 ERBB4 RGS16 TNF MYB PRL KLF2 TFS REGULATE MIRNAS RELATED TO CARDIAC HYPERTROPHY%WIKIPATHWAYS_20200510%WP1559%HOMO SAPIENS TFs Regulate miRNAs related to cardiac hypertrophy MYEF2 TGFB1 MIR125B1 MIR125B2 RASGRF1 MIR133B NFKB1 AKT2 STAT3 AKT1 PPP3R1 MIR1-1 LNCRNA INVOLVEMENT IN CANONICAL WNT SIGNALING AND COLORECTAL CANCER%WIKIPATHWAYS_20200510%WP4258%HOMO SAPIENS LncRNA involvement in canonical Wnt signaling and colorectal cancer FZD6 FZD9 FZD8 FOSL1 CDK8 H19 HNRNPK H2AFY2 TCF3 EZH2 GSK3B WNT2B MIR34A CHD8 SOST APC2 KREMEN1 AXIN1 MIR7-1 AXIN2 MIR16-2 SENP2 WNT16 LEF1 LRP5 CXXC4 NKD1 NKD2 LRP6 MIR16-1 WNT11 WIF1 TCF7L2 TCF7L1 RYK CSNK1A1 WNT7B WNT7A MIR6808 APC CTNNB1 NOTUM CSNK1A1L CCND1 CDK6 HNRNPU FZD10 CCND3 FRAT1 FRAT2 CCND2 SOX17 PLAU MYC RUVBL1 MAP3K7 CER1 WNT5B CSNK2A1 CSNK2A3 SERPINF1 CSNK2A2 CTNNBIP1 WNT5A CSNK1E DKK1 DKK2 DKK4 SFRP4 SFRP1 SFRP2 SFRP5 CSNK2B ROR1 ROR2 ATF3 CTBP2 CTBP1 TCF7 NLK WNT6 PORCN DVL1 DVL2 DVL3 WNT1 WNT2 MIR4683 WNT3 WNT4 TFAP2A FZD1 WNT10B JUN FZD3 WNT10A FZD2 FZD5 WNT3A FZD7 MAJOR RECEPTORS TARGETED BY EPINEPHRINE AND NOREPINEPHRINE%WIKIPATHWAYS_20200510%WP4589%HOMO SAPIENS Major receptors targeted by epinephrine and norepinephrine ADCY4 ADCY3 ADRA1D ADCY10 ADRB2 ADRA2C ADCY7 ADRA2A ADCY6 ADCY5 ADCY9 ADRB1 ADCY1 ADCY2 ADCY8 CORTICOTROPIN-RELEASING HORMONE SIGNALING PATHWAY%WIKIPATHWAYS_20200510%WP2355%HOMO SAPIENS Corticotropin-releasing hormone signaling pathway FOSL1 CASP9 GSK3B CASP3 AKT1 PRKCB PRKCA CXCL8 MAPK9 ARRB1 MAPK8 ARRB2 ELK1 PLCG2 CRHBP MAPK1 NOS3 GJA1 CASP12 MAP2K1 TRIM28 PLCG1 SULT2A1 MAP3K5 NCOA2 PTK2 HSP90AA1 CTNNB1 PRKCI PARP1 JUNB PRKCD KRT1 IL18 RHOA BRAF ERN1 CYP21A2 CRH RAF1 PRKCQ FOS TLR4 RAPGEF3 IVL GNAZ PRKAA2 SP1 ACACA CRHR1 CACNA1H GNAI2 CRHR2 CYP11A1 ADRBK2 GNA11 GRK6 TGFB1 JUND HSD3B2 JUP GNB1 HSD3B1 TBX19 IL2 FOSL2 GNAO1 NR4A2 POMC NR4A1 STAR GNAQ GNB2 BCL2 CYP11B1 KRT14 GNB3 FOSB TCF4 ECE1 CAMK2A GNAI1 RAP1B GNB5 MAPK14 CREB1 RELA TFAP2A NFKB1 GNAS NFKBIA MAPK3 SEROTONIN AND ANXIETY-RELATED EVENTS%WIKIPATHWAYS_20200510%WP3944%HOMO SAPIENS Serotonin and anxiety-related events NLGN1 PLEK HTR1A HTR2C HTR2A PRKCB GRIN2D ARC CRH PLCD4 FOS CRHR1 PPP3CA SMALL LIGAND GPCRS%WIKIPATHWAYS_20200510%WP247%HOMO SAPIENS Small Ligand GPCRs PTGER3 LPAR1 GPR50 MTNR1A CNR2 PTGIR MTNR1B CNR1 TBXA2R S1PR1 S1PR3 S1PR2 S1PR4 PTGDR PTGER4 PTGFR PTGER1 PTGER2 PTAFR CHOLESTEROL METABOLISM (INCLUDES BOTH BLOCH AND KANDUTSCH-RUSSELL PATHWAYS)%WIKIPATHWAYS_20200510%WP4718%HOMO SAPIENS Cholesterol metabolism (includes both Bloch and Kandutsch-Russell pathways) MVK MSMO1 MIR1908 HMGCR CYP46A1 HSD17B7 TM7SF2 FADS2 EBP NSDHL PMVK SC5D HMGCS2 LBR FADS1 FDFT1 ABCA1 FDPS SREBF1 MYLIP HMGCS1 ELOVL4 GGPS1 ELOVL5 ACSL1 NR1H2 ELOVL2 ELOVL3 CYP51A1 NR1H3 DHCR24 ACSL4 ACSL3 LSS SREBF2 CYP27A1 SQLE CH25H SOAT1 SCD SOAT2 FASN ACOT2 MVD DHCR7 ABCG1 IDI1 IRINOTECAN PATHWAY%WIKIPATHWAYS_20200510%WP229%HOMO SAPIENS Irinotecan Pathway UGT1A1 CYP3A4 CYP3A5 SLCO1B1 NPC1 UGT1A9 CES2 CES1 ABCG2 UGT1A10 BCHE ABCC1 ABCC2 HOST-PATHOGEN INTERACTION OF HUMAN CORONA VIRUSES - AUTOPHAGY%WIKIPATHWAYS_20200510%WP4863%HOMO SAPIENS Host-pathogen interaction of human corona viruses - autophagy RB1CC1 ULK2 ULK1 PIK3C3 ATG4A ATG7 BECN1 ATG3 PIK3R4 ATG10 WIPI1 ATG13 ZFYVE1 MTOR ATG12 MAP1LC3A EXTRACELLULAR VESICLES IN THE CROSSTALK OF CARDIAC CELLS%WIKIPATHWAYS_20200510%WP4300%HOMO SAPIENS Extracellular vesicles in the crosstalk of cardiac cells CD63 MIR20A MIR17 CD81 PTEN HSPB1 GATA4 EGFR MIR320A ETS2 SPP1 PDLIM5 MIR19B1 SORBS2 IGF1 MIR19A MMP9 MIR92A1 MIR17HG KDR BIRC5 EGF TLR4 SOD1 STAT3 IL6 NOTCH SIGNALING PATHWAY NETPATH%WIKIPATHWAYS_20200510%WP61%HOMO SAPIENS Notch Signaling Pathway Netpath TLE1 RING1 CDKN1A FBXW7 SAP30 NCOR2 ADAM17 NCOR1 CCND1 LCK NUMB MAML3 GSK3B MAPT AKT1 NOTCH2 NOTCH3 HDAC2 NUMBL NOTCH1 HDAC1 NOTCH4 CUL1 PSEN2 DTX1 GATA3 PSEN1 DLL1 SRC DLL3 DLL4 APH1A NCSTN APH1B HES5 JAG2 SPEN JAG1 ITCH SNW1 MIR1281 MYC PIK3R2 PIK3R1 HEY1 HES1 HIF1A MAML2 MAML1 FHL1 RBPJ HEY2 NFKB1 MAGEA1 EP300 CIR1 STAT3 JAK2 SKP1 PSENEN PTCRA HES6 INSULIN SIGNALING%WIKIPATHWAYS_20200510%WP481%HOMO SAPIENS Insulin Signaling MAP2K6 GSK3B PIK3CD SRF MAPK9 MAPK8 MAPK1 HRAS MAP2K1 MAP2K2 MAPK12 MAPK13 MAPK10 MAPK11 GRB2 SOS1 RAF1 IRS1 REG1A INPPL1 PIK3R3 IRS4 PTPN11 CBLC PIK3R2 IRS2 PIK3R1 CBLB PIK3CB IGF1R RPS6KA4 PIK3CA LIPE RPS6KA3 RPS6KA6 RPS6KA5 GRB14 KIF5B RPS6KA2 RPS6KA1 GRB10 ENPP1 MAP3K8 MAP3K9 MAP3K6 GYG1 MAP3K4 MAP2K4 PRKCH TSC2 TSC1 INPP4A TRIB3 SHC2 SHC3 STXBP3 RRAD STXBP4 SHC1 STXBP1 STXBP2 PPP1R3A PRKCZ MAPK3 FOXO1 SOCS3 SOCS1 KIF3A EIF4EBP1 MAP2K7 MAP2K5 EGR1 XBP1 RAB4A INSR EHD1 AKT2 ARHGAP33 EHD2 RHEB AKT1 MAP3K10 MIR3620 MAP3K13 MAP3K14 MAP3K11 PRKCB MAP3K12 PRKCA SNAP25 ARF1 GSK3A SNAP23 SLC2A1 SOS2 PIK3C2G PIK3C2A PIK3CG PTPRF FOXO3 GYS2 GYS1 RAC2 FLOT1 FLOT2 RAC1 ELK1 MAP4K1 CAP1 MAP4K2 PDPK1 MINK1 GAB1 MAP3K5 TBC1D4 RHOJ RAPGEF1 PRKCI SGK3 SGK1 PRKCD SGK2 CRK VAMP2 RHOQ ARF6 PRKAA1 CBL PRKCQ CYTH3 FOS MAPK7 STX4 MAP4K5 MAPK6 PRKAA2 EIF4E PIK3R4 SH2B2 MAPK4 MAP4K3 MAP4K4 MAP3K2 MAP3K3 MTOR PTPN1 SORBS1 PFKL MYO1C RPS6KB1 PIK3C3 RPS6KB2 PFKM MAP3K7 PTEN MAP2K3 MAP3K1 SLC2A4 MAPK14 IKBKB JUN GENES RELATED TO PRIMARY CILIUM DEVELOPMENT (BASED ON CRISPR)%WIKIPATHWAYS_20200510%WP4536%HOMO SAPIENS Genes related to primary cilium development (based on CRISPR) TRAF3IP1 IFT172 CEP19 CEP120 TXNDC15 CDK20 TRAPPC11 CEP97 KIFAP3 DYNC2H1 ARMC9 IFT80 RPGRIP1L LZTFL1 IFT88 IFT81 C14orf80 WDPCP CEP104 ARL6 ARL3 FBF1 TTBK2 DYNC2LI1 KIF3B TTC21B INPP5E TCTEX1D2 FOPNL CEP192 PIBF1 CEP76 BBS2 BBS1 RABL2A C16orf59 RABL2B IFT122 FUZ TMEM231 IFT20 ICK TMEM17 WDR60 SASS6 MKS1 IFT27 CEP83 FGFR1OP TTC26 TTC23 C2CD3 CBY1 C5orf42 EFCAB7 HSPB11 IFT52 TCTN3 TCTN2 TCTN1 TMEM107 BBS9 BBS7 IFT57 CC2D2A BBS5 BBS4 OFD1 KIF3A MKKS DYNLT1 IFT140 CEP295 IQCE DYNLL1 WDR34 WDR35 BBS10 EVC IFT43 BBS12 TMEM216 IFT46 TUBD1 KATNB1 TULP3 IFT74 ARL13B RAB23 TMEM67 KIAA0753 EVC2 WDR19 SCLT1 TUBE1 FAM92A1 RSG1 MIB1 TTC8 TTC30B CEP162 B9D1 CLUAP1 CEP44 CONVERSION OF ANGIOTENSINOGEN TO ANGIOTENSIN II %WIKIPATHWAYS_20200510%WP4818%HOMO SAPIENS Conversion of Angiotensinogen to Angiotensin II ACE CMA1 CTSG DISRUPTION OF POSTSYNAPTIC SIGNALLING BY CNV%WIKIPATHWAYS_20200510%WP4875%HOMO SAPIENS Disruption of postsynaptic signalling by CNV NLGN1 NLGN3 CAMK2B GRIN2D CYFIP1 ARC RYR2 CAMK2D NLGN2 NRXN1 FMR1 NRXN3 NRXN2 RPH3A SYNGAP1 DLGAP1 CAMK2G CAMK2A YWHAG NLGN4X HOMER1 GRIN2C GRM1 MAPK1 GRIN2B TJP1 DLG1 DLG2 MIR5004 STX1A SHANK1 GRIN2A GRIN1 MAPK3 HYPOTHETICAL CRANIOFACIAL DEVELOPMENT PATHWAY%WIKIPATHWAYS_20200510%WP3655%HOMO SAPIENS Hypothetical Craniofacial Development Pathway WNT1 TGFB3 FGD5P1 ARHGAP29 TFAP2A IRF6 TP63 RHOA GPCRS, CLASS B SECRETIN-LIKE%WIKIPATHWAYS_20200510%WP334%HOMO SAPIENS GPCRs, Class B Secretin-like GLP1R ADCYAP1R1 VIPR1 VIPR2 GIPR GCGR GLP2R SCTR PTH2R PTH1R ADGRE1 ADGRE2 GHRHR CRHR1 CALCR CALCRL ADGRG2 ADGRE5 CRHR2 ADGRL1 ADGRL4 ADGRL2 ADGRL3 NUCLEAR RECEPTORS IN LIPID METABOLISM AND TOXICITY%WIKIPATHWAYS_20200510%WP299%HOMO SAPIENS Nuclear Receptors in Lipid Metabolism and Toxicity ABCC3 ABCG5 MIR33B MIR33A CYP4A11 NR1H4 CYP4B1 CYP8B1 CYP2C9 CYP24A1 CYP1A2 PPARG CYP2E1 PPARA PPARD ABCA1 RARB NR1H3 ABCC2 CYP3A4 RARA ABCG1 VDR RARG CYP26A1 ABCD2 ABCD3 ABCB1 ABCB4 NR1I3 CYP4A22 NR1I2 ABCB11 CYP7A1 CYP27B1 CYP2B6 SEROTONIN AND ANXIETY%WIKIPATHWAYS_20200510%WP3947%HOMO SAPIENS Serotonin and anxiety GRM1 GABRA1 TRPV1 POMC PLEK HTR1A HTR2C HTR2A CAMK2B PRKCB ARC CRH PLCD4 FOS FMR1 PPP3CA ADRA1A RENIN ANGIOTENSIN ALDOSTERONE SYSTEM (RAAS)%WIKIPATHWAYS_20200510%WP4756%HOMO SAPIENS Renin Angiotensin Aldosterone System (RAAS) AGTR2 CAMK1 HSD3B2 PLCB2 CAMK1G HSD3B1 CREB5 ATF4 ACE CMA1 CTSG STAR GNAQ CAMK2B CAMK2D CAMK2G CAMK2A ATF1 ATF2 CALML5 ATF6B CALML6 CYP21A2 ITPR1 ITPR2 ITPR3 CALML3 CREB1 CALML4 CREB3L3 CAMK4 CREB3L4 CREB3L1 CALM3 CREB3L2 CALM1 CAMK1D CALM2 AGT CREB3 CYP11A1 CYP11B2 AGTR1 REN OSTEOPONTIN SIGNALING%WIKIPATHWAYS_20200510%WP1434%HOMO SAPIENS Osteopontin Signaling ITGB3 MAPK1 ITGAV MAP2K1 MMP9 MAP3K14 CHUK PLAU RELA NFKB1 IKBKB MAPK3 SPP1 CONSTITUTIVE ANDROSTANE RECEPTOR PATHWAY%WIKIPATHWAYS_20200510%WP2875%HOMO SAPIENS Constitutive Androstane Receptor Pathway ABCC3 CYP4A11 CYP2C9 ABCC2 UGT1A1 CYP3A4 CYP3A5 ALAS1 CYP2C19 UGT1A9 SULT2A1 SULT1A1 PPP2R4 NCOA2 UGT1A4 HSP90AA1 UGT1A3 PPARGC1A NCOA1 UGT1A6 NCOA6 SMC1A CYP2A6 DNAJC7 GSTA2 EHHADH ABCB1 SP1 NR1I3 CYP4A22 FOXO1 RXRA CYP2B6 TYPE I COLLAGEN SYNTHESIS IN THE CONTEXT OF OSTEOGENESIS IMPERFECTA%WIKIPATHWAYS_20200510%WP4786%HOMO SAPIENS Type I collagen synthesis in the context of Osteogenesis imperfecta FKBP10 TNFRSF11B PLOD2 MIA3 TNFRSF11A PLOD1 ADAMTS2 SERPINH1 TNFSF11 TMEM38B COLGALT1 IFITM5 MBTPS1 CRTAP P3H2 P3H1 COL1A2 BMP1 LOX P4HA1 P4HA2 SP7 P4HB PPIB LRP5 SERPINF1 MBTPS2 LRP6 COL1A1 ITPR1 WNT1 CREB3L1 ARIPIPRAZOLE METABOLIC PATHWAY%WIKIPATHWAYS_20200510%WP2640%HOMO SAPIENS Aripiprazole Metabolic Pathway CYP2D6 CYP3A43 SIGNALING PATHWAYS IN GLIOBLASTOMA%WIKIPATHWAYS_20200510%WP2261%HOMO SAPIENS Signaling Pathways in Glioblastoma RB1 MAP2K6 MAP2K7 CDKN1A MAP2K5 ARAF CCND1 AKT2 AKT1 PRKCG PRKCB PRKCA PIK3C2G TP53 PIK3C2A PIK3CG SRC PIK3CD FOXO3 PDGFRA EGFR ERBB2 NRAS E2F1 AKT3 PLCG2 MAPK1 HRAS MAP2K1 PDPK1 MIR1281 MAP2K2 PLCG1 GAB1 PRKCI PRKCD CDKN2A KRAS BRAF GRB2 CDK6 RAF1 CBL CDK4 PRKCQ ERRFI1 CDKN1B BRCA1 BRCA2 PIK3C2B PDGFRB MSH6 CCNE1 FGFR2 MET FOXO4 FGFR1 ERBB3 CDKN2B CDKN2C CDK2 NF1 MDM2 SPRY2 MDM4 ATM CCND2 IRS1 PIK3R2 PIK3R1 PTEN PIK3CB IGF1R PIK3CA MAP2K3 MAP2K4 PRKCH TSC2 TSC1 EP300 PRKCZ MAPK3 FOXO1 TYPE II DIABETES MELLITUS%WIKIPATHWAYS_20200510%WP1584%HOMO SAPIENS Type II diabetes mellitus PDX1 CACNA1A MAPK1 SLC2A2 MAFA PHKA2 PIK3R5 INSR INS-IGF2 SOCS4 PRKCD SLC2A4 IRS1 TNF IKBKB PRKCZ SURF1 KCNJ11 MTOR GK MAPK8 ADIPOQ MECHANOREGULATION AND PATHOLOGY OF YAP/TAZ VIA HIPPO AND NON-HIPPO MECHANISMS%WIKIPATHWAYS_20200510%WP4534%HOMO SAPIENS Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms PAK7 ITGB8 PAK6 ITGB7 ITGB6 PAK3 PAK2 TEAD1 TEAD2 PAK4 TEAD3 ACTA2 TEAD4 MST1 YY1AP1 LATS1 ACTA1 NF2 ITGB1 SRC MAPK9 MAPK8 ITGB3 ACTG2 MAP4K1 MAP4K2 ACTB ACTG1 CTNNB1 MAPK10 SGMS1 ITGB5 MAP4K5 ITGB4 ITGB2 TAZ ACTC1 LIMD1 STK3 MAP4K3 SAV1 MAP4K4 PAK1 YWHAQ CDH1 CTNNA1 BILE ACIDS SYNTHESIS AND ENTEROHEPATIC CIRCULATION %WIKIPATHWAYS_20200510%WP4389%HOMO SAPIENS Bile Acids synthesis and enterohepatic circulation ABCG5 MAPK1 ABCG8 SLC10A1 SLC10A2 FXR1 FGF19 MIR6886 FGFR4 LDLR MAPK3 ABCB11 CYP7A1 MIR-517 RELATIONSHIP WITH ARCN1 AND USP1%WIKIPATHWAYS_20200510%WP3596%HOMO SAPIENS miR-517 relationship with ARCN1 and USP1 CDKN1A ID2 ID1 USP1 ARCN1 PRION DISEASE PATHWAY%WIKIPATHWAYS_20200510%WP3995%HOMO SAPIENS Prion disease pathway SPI1 CASP3 CTCF SMC3 CHD2 HSP90B1 BCL2 MIR3610 RAD21 FYN NCAM1 MIR3652 MIR3175 PDIA3 PRNP MEF2C TBP HSPA5 BCL11A EBF1 PAX5 POU2F2 BATF IRF4 ELK1 RFX5 MAPK1 CASP12 MIR1281 PTK2 CREB1 NFKB1 EP300 STAT3 MAPK3 RXRA FGFR1 ENDODERM DIFFERENTIATION%WIKIPATHWAYS_20200510%WP2853%HOMO SAPIENS Endoderm Differentiation SOX7 EOMES WDHD1 SFMBT1 ZNF281 FOXH1 HNF1B PAX3 CDYL PIAS1 RFX7 EZH2 RAB38 WDFY2 TOX BCORL1 CTR9 NOTCH1 GATA6 PRDM14 RTF1 MBTD1 EPB41L5 C11orf30 UBR5 NKX2-1 OTX2 LEF1 BPTF SMAD2 ZBTB17 ATP8B2 SIAH2 PBX3 FOXN3 GDF3 BMP7 ZFHX4 TCF7L1 TRERF1 PBX1 EXT1 DAB2 MIR7705 LHX1 APC SP4 CTNNB1 NABP2 TAF4B PAF1 PLCH1 NANOG NODAL BMPR1A TRIM71 SCHIP1 NCAPG2 ONECUT1 LAMC1 ELAVL1 PHF6 HOXC11 CDC73 GLI2 IQCJ-SCHIP1 HHEX TRIM5 ZIC3 C1QBP DNMT3B JARID2 FOXA2 VAV3 DUSP4 DUSP5 DUSP2 SLC2A12 NOG TET1 POU5F1 NME1 PARP8 TOX3 AEBP2 DDAH1 MTF2 PAX9 PABPC1 AHDC1 WNT8A PTHLH BTAF1 CAND1 TBX21 TCEAL2 MIR373 LEO1 ASCC3 KDM4A ZNF462 STAT1 ZIC5 ELP4 GRHL2 LRPPRC MAD2L2 TNRC6C MIR141 RGS10 CEBPZ TAF5 NAA15 MIXL1 CUL4B RARG FOXO1 HPRT1 ACACA TGFB1 SOX17 TCF4 CER1 GATA4 DKK1 SFRP1 CTBP2 TCF7 MAP2K3 NLK SMAD4 SMAD3 NR3C1 WNT3 FOXA1 APP CRTC1 WWC1 SOX21 SOX2 ELK4 SESN1 CEP250 HOXA1 DIP2A MAPK SIGNALING PATHWAY%WIKIPATHWAYS_20200510%WP382%HOMO SAPIENS MAPK Signaling Pathway MAPT SRF CDC42 FGFR2 FGF10 FGFR1 DUSP4 TGFB3 DUSP2 RPS6KA4 RPS6KA3 RPS6KA5 MAP3K8 MAP3K6 MAP3K4 MAP2K4 MAP2K7 MAP2K5 MAP3K13 MAP3K14 MAP3K11 MAP3K12 RAC2 ARRB1 RAC1 ARRB2 ELK1 MAP4K1 MAP4K2 MAP3K5 PRKCD CRK ATF2 FOS MAPK7 MAP4K3 CACNA1H MAP4K4 MAP3K2 JUND ATF4 NR4A1 PPP5D1 STMN1 DAXX IL1R1 IL1R2 CACNA2D1 CACNA2D3 CACNA2D2 CACNA2D4 RAP1B MAPK8IP2 MAPK8IP3 MAPK8IP1 MIR3917 RAP1A PRKACG DDIT3 PDGFA MAP2K3 PRKACA PPP3R2 PRKACB RRAS MAP3K1 CD14 NFATC3 CHUK GNG12 PPP5C DUSP1 NFATC1 PTPRR ECSIT MAPK14 PPP3CB PPP3CC TNF RAC3 RELA DUSP3 NFKB1 IKBKB RRAS2 DUSP8 PPP3CA DUSP9 DUSP6 PPP3R1 DUSP7 IL1A MRAS IKBKG IL1B RAPGEF2 MAP2K6 RELB NTF4 NTF3 FLNA FLNB FLNC HSPA1L TAOK3 TAOK1 TAOK2 FAS LAMTOR3 HSPA1B HSPA1A FGF1 FGF3 FGF4 FGF5 FGF6 FGF7 FGF9 CDC25B CACNB1 CACNB2 CACNB3 CACNB4 MAPKAPK3 EGFR MAPKAPK2 MAPKAPK5 MAPK9 MAX MAPK8 NRAS CACNA1B AKT3 CACNA1D CACNA1C MAPK1 PDGFB HRAS CACNA1F MAP2K1 RASGRP2 MAP2K2 CACNA1E FGF2 RASGRP1 RASGRP4 RASGRP3 CACNA1G MAPK12 CACNA1I MAPK13 FGF20 CACNA1S MAPK10 FGF23 MAPK11 FGF22 KRAS GRB2 FGF21 HSPA8 TGFB2 SOS1 RAF1 BDNF HSPA6 HSPA2 NFKB2 FGF17 FGF16 FGF14 FGF18 TAB2 TAB1 PDGFRB FGF13 FGFR3 FGF12 FGF11 RASGRF2 LRRK2 FASLG DUSP16 DUSP10 NF1 PLA2G4F PLA2G4D PLA2G4E PLA2G4B PLA2G4C PLA2G4A TRAF2 NGF TGFBR1 TGFBR2 TNFRSF1A PPM1A PPM1B TRAF6 RASA1 RASA2 CACNG6 CACNG7 CACNG8 MIR4523 MKNK1 GNA12 MKNK2 CACNG1 CACNG2 CACNG3 CACNG4 CACNG5 NTRK1 CACNA1A NTRK2 MIR935 PTPN7 PTPN5 STK3 MAPK3 PAK1 ARAF PAK2 AKT2 CASP3 AKT1 PRKCG PRKCA SOS2 TP53 STK4 GADD45A EGF BRAF FGF19 FGFR4 TGFB1 RASGRF1 MYC MAP3K7 MEF2C HSPB1 NLK CRKL FGF8 JUN ELK4 REGULATION OF MICROTUBULE CYTOSKELETON%WIKIPATHWAYS_20200510%WP2038%HOMO SAPIENS Regulation of Microtubule Cytoskeleton DIAPH1 PTPRA CDK1 F2RL2 TAOK1 GSK3B MAPT AKT1 PRKCA SRC MAPKAPK2 CDC42 RAC1 MIR6808 APC GNAQ MIR4523 PTEN PIK3CA STMN1 MIR3917 TRIO TESK2 SPRED1 PRKACA DPYSL2 CFL2 DVL1 EPHB2 TIAM1 CLIP1 MAP1B KIF2C MAPRE1 PHLDB2 ROCK1 CAMK4 AURKB PARD6A ABL1 RHO STAT3 TPPP PAK1 CLASP1 MARK2 MARK1 WNT3A LIMK1 COMPUTATIONAL MODEL OF AEROBIC GLYCOLYSIS%WIKIPATHWAYS_20200510%WP4629%HOMO SAPIENS Computational Model of Aerobic Glycolysis PKM TPI1 PGAM2 PGK1 ENO1 PFKM SLC2A1 ALDOA GAPDH HK1 GPI LDHA OXIDATIVE PHOSPHORYLATION%WIKIPATHWAYS_20200510%WP623%HOMO SAPIENS Oxidative phosphorylation MT-ND6 MT-ND4L MT-ND4 MT-ND5 NDUFA11 NDUFA10 ATP5G3 ATP5G2 MT-ND2 ATP5G1 MT-ND3 MT-ND1 MT-ATP6 ATP6AP1 ATP6AP2 NDUFC2 NDUFC1 ATP5F1 ATP5J2 NDUFS8 NDUFS7 NDUFS6 NDUFS5 NDUFS4 NDUFS3 NDUFS2 NDUFS1 MIR4691 ATP5S NDUFB9 NDUFB8 NDUFB7 NDUFB10 NDUFB6 NDUFB5 NDUFB4 ATP5A1 NDUFA4L2 NDUFB2 ATP5J NDUFB1 ATP5I ATP5H ATP5O ATP5L ATP5B ATP5E ATP5D NDUFV3 NDUFV2 MIR7113 NDUFV1 NDUFA9 NDUFA8 NDUFA7 NDUFA6 NDUFA5 NDUFA4 NDUFA2 GZMB NDUFAB1 SEROTONIN RECEPTOR 2 AND STAT3 SIGNALING%WIKIPATHWAYS_20200510%WP733%HOMO SAPIENS Serotonin Receptor 2 and STAT3 Signaling STAT3 JAK2 GNAQ HTR2A GUT-LIVER INDOLE METABOLISM %WIKIPATHWAYS_20200510%WP3627%HOMO SAPIENS Gut-Liver Indole Metabolism CYP2E1 SEROTONIN RECEPTOR 4/6/7 AND NR3C SIGNALING%WIKIPATHWAYS_20200510%WP734%HOMO SAPIENS Serotonin Receptor 4/6/7 and NR3C Signaling ELK1 RPS6KA5 MAPK1 EGR1 MAP2K1 MAP2K2 RAP1A HTR4 ATF1 HTR6 HTR7 BRAF NR3C1 CREB1 GNAS SRF ELK4 MAPK3 MAPKAPK2 IL-7 SIGNALING PATHWAY%WIKIPATHWAYS_20200510%WP205%HOMO SAPIENS IL-7 Signaling Pathway CCND1 GSK3B AKT1 JAK3 MYC FYN PIK3R2 PIK3R1 STAT1 MAPK1 MAP2K1 MAP2K2 STAT5A STAT5B BAD IL2RG PTK2B IL7 IL2RA IL7R BCL2L1 CDKN1B STAT3 MAPK3 JAK1 CELL DIFFERENTIATION - INDEX%WIKIPATHWAYS_20200510%WP2029%HOMO SAPIENS Cell Differentiation - Index MIR302E MIR203A MIR302A MEF2D LEFTY2 MIR3074 MIR133B MIR181A2 MIR181A1 MEF2A LEFTY1 MEF2B MIR181C MIR26A1 MIR26A2 MIR199A2 MIR222 MIR145 MIR221 TLX3 TLX2 MIR16-2 MYOD1 TLX1 MIR199A1 MEF2C MIR181B1 MIR181D MIR181B2 SRF MIR16-1 STAT3 HDAC5 MIR302D MIR302C MIR1-1 PHOTODYNAMIC THERAPY-INDUCED AP-1 SURVIVAL SIGNALING.%WIKIPATHWAYS_20200510%WP3611%HOMO SAPIENS Photodynamic therapy-induced AP-1 survival signaling. RB1 MAP2K6 MAP2K7 CDKN1A CCND1 FAS FGF7 TP53 PDGFRA EGFR MAPK8 ELK1 BAK1 BID MAP3K5 HSP90AA1 MAPK12 MAPK13 JUNB CDKN2A MAPK11 ATF2 BAX FOS BCL2L1 CCNE1 NFE2L2 FASLG IL2 TRAF2 TNFRSF1A BCL2 TRAF6 TNFSF10 MMP2 CCNA2 IFNG TRAF5 HBEGF MIR8085 MAP2K3 BCL2L11 MAP2K4 BMF MCL1 CFLAR BCL3 MAPK14 TNF JUN IL6 LEPTIN SIGNALING PATHWAY%WIKIPATHWAYS_20200510%WP2034%HOMO SAPIENS Leptin signaling pathway RPS6 EIF4EBP1 KHDRBS1 ROCK2 ACACB SOCS2 SOCS7 SH2B1 CCND1 ESR1 LEP REL GSK3B AKT1 GSK3A SRC CDC42 MAPK8 ERBB2 RAC1 ELK1 PLCG2 MAPK1 NOS3 HRAS MAP2K1 MAP2K2 PLCG1 PTK2 STAT5B BAD RHOA GRB2 SOS1 PRKAA1 RAF1 BAX BCL2L1 PRKAA2 EIF4E SP1 ACACA MTOR PTPN1 RPS6KB1 FYN IRS1 PTPN11 PIK3R2 PIK3R1 PTEN STAT1 RPS6KA1 NCOA1 CFL2 CHUK MAPK14 CREB1 ROCK1 RELA SHC1 NFKB1 IKBKB STAT3 IL1RN JAK2 MAPK3 PDE3B JAK1 FOXO1 LEPR SOCS3 KPNA4 IKBKG CISH IL1B GLYCOGEN SYNTHESIS AND DEGRADATION%WIKIPATHWAYS_20200510%WP500%HOMO SAPIENS Glycogen Synthesis and Degradation GSK3B GSK3A PYGB GBE1 GYS2 PPP2R2A PPP2CA GYS1 PYGM PYGL HK2 HK3 PPP2CB UGP2 PHKG1 PPP2R1B PPP2R5E PHKA2 PPP2R1A PHKG2 HK1 PPP2R4 GYG2 PGM1 AGL GYG1 PPP2R5B PPP2R5A PPP2R5D PPP2R3B PHKA1 PHKB PPP2R3A PPP2R5C PPP2R2C PPP2R2B HKDC1 CALM3 CALM1 CALM2 DISORDERS OF THE KREBS CYCLE%WIKIPATHWAYS_20200510%WP4236%HOMO SAPIENS Disorders of the Krebs cycle PDHX FH SUCLA2 DLST SUCLG2 SUCLG1 DHTKD1 IL1 AND MEGAKARYOCYTES IN OBESITY%WIKIPATHWAYS_20200510%WP2865%HOMO SAPIENS IL1 and megakaryocytes in obesity PIK3CA PLA2G7 ICAM1 IL1R1 SELENBP1 IRAK1 NLRP3 FCER1A MMP9 CCL2 TIMP2 TIMP1 CCR3 IFNG F2R MIR718 HBEGF F2 TLR1 S100A9 IL18 MYD88 TLR2 NFKB1 IL1B CELL DIFFERENTIATION - INDEX EXPANDED%WIKIPATHWAYS_20200510%WP2023%HOMO SAPIENS Cell Differentiation - Index expanded MIR302E PAX7 MIR203A MIR302A ID2 MEF2D LEFTY2 MIR3074 MIR133B MIR181A2 MIR181A1 MEF2A LEFTY1 EZH2 MEF2B MIR181C MIR26A1 MIR26A2 MIR199A2 MIR222 MIR145 MIR221 TLX3 TLX2 MIR16-2 MYOD1 TLX1 MIR199A1 MEF2C MIR181B1 MIR181D MIR181B2 SRF MIR16-1 SOX2 STAT3 HDAC5 MIR302D KLF4 MIR302C MIR1-1 RUNX2 ATM SIGNALING PATHWAY%WIKIPATHWAYS_20200510%WP2516%HOMO SAPIENS ATM Signaling Pathway CDKN1A CDK1 CDK2 MDC1 PIDD1 MDM2 CCNB1 CHEK2 MDM4 CHEK1 ATM CASP2 TLK1 RIPK1 TP53BP1 NBN CRADD H2AFX MRE11A CDC25C AP3B2 CDC25A RAD50 RAD51 FANCD2 TP53 RAD9A TP73 MAPK9 BID GADD45A ATF2 SMC1A CREB1 BRCA1 ABL1 JUN NFKBIA CCNE1 IKBKG APOPTOSIS%WIKIPATHWAYS_20200510%WP254%HOMO SAPIENS Apoptosis CASP9 CASP8 CASP2 CASP3 AKT1 RIPK1 FAS CRADD TP53 TP73 BAK1 BID BAD MAPK10 CDKN2A HRK TRADD PRF1 BBC3 CASP7 BAX CASP6 CYCS CASP10 CASP4 CASP1 BCL2L1 BOK DFFB HELLS BNIP3L DFFA APAF1 SCAF11 TRAF1 TNFRSF1B IRF3 FASLG TRAF3 IRF1 MIR7846 IRF2 LTA MDM2 IRF7 IRF6 TP63 TNFRSF25 IRF5 BIRC2 TRAF2 TNFRSF21 BIRC3 MIR3191 DIABLO TNFRSF1A MIR3190 BCL2 XIAP PMAIP1 MYC FADD IGF2 TNFRSF10B NFKBIE BCL2L2 NFKBIB PIK3R1 IGF1R IRF4 IGF1 TNFSF10 BIRC5 BCL2L11 MAP2K4 MCL1 MAP3K1 GZMB CFLAR CHUK TNF RELA NFKB1 IKBKB JUN NFKBIA IKBKG MACROPHAGE MARKERS%WIKIPATHWAYS_20200510%WP4146%HOMO SAPIENS Macrophage markers CD83 LYZ CD68 F3 CD86 RAC2 CD74 CD14 CD163 AMP-ACTIVATED PROTEIN KINASE (AMPK) SIGNALING%WIKIPATHWAYS_20200510%WP1403%HOMO SAPIENS AMP-activated Protein Kinase (AMPK) Signaling EIF4EBP1 CDKN1A ACACB CCNB1 INSR AKT2 LEP CRTC2 PRKAG1 AKT1 PRKAG2 ADRA1B PRKAG3 RPTOR STK11 EEF2K HNF4A PRKAB2 CPT1A STRADA STRADB TP53 CPT1C PIK3CG CPT1B PRKAB1 PIK3CD GYS2 CCNA1 GYS1 PFKFB3 CAB39 ADIPOR1 MEF2BNB-MEF2B ADIPOR2 CAMKK1 CAMKK2 PPARGC1B EEF2 SLC2A4RG PRKAA1 ELAVL1 PRKAA2 ACACA MTOR RPS6KB1 PIK3C3 HMGCR RPS6KB2 SREBF1 PIK3R3 PIK3R2 PIK3R1 PIK3CB PIK3CA LIPE ADRA1A ADIPOQ CCNA2 INS-IGF2 FASN PRKACG PRKACB SLC2A4 TSC2 TSC1 PLCB1 LEPR TGF-BETA RECEPTOR SIGNALING%WIKIPATHWAYS_20200510%WP560%HOMO SAPIENS TGF-beta Receptor Signaling ITGB6 FOXH1 LEF1 SMAD2 MAPK9 SMAD1 CREBBP HRAS MIR1281 CTNNB1 EGF FOS ZFYVE9 TGFB1 SERPINE1 MIR302A TGIF1 FST LEFTY2 TFE3 NOG RUNX3 TGFBR3 ZEB2 LEFTY1 ENG LTBP1 THBS1 TGFBR1 MIR6869 TGFBR2 ZNF423 SKIL LIF SMAD9 INHBA SMAD6 SMAD5 SMAD7 SKI BMP4 FKBP1A BAMBI STAT1 SPP1 IFNG SMAD4 SMAD3 WNT1 TNF NFKB1 EP300 JUN STAT3 MAPK3 JAK1 RUNX2 INITIATION OF TRANSCRIPTION AND TRANSLATION ELONGATION AT THE HIV-1 LTR%WIKIPATHWAYS_20200510%WP3414%HOMO SAPIENS Initiation of transcription and translation elongation at the HIV-1 LTR NFATC4 CDK9 MIR3960 HDAC2 HDAC1 CREBBP MIR1281 PPP3R2 NFATC3 HDAC4 HDAC3 CCNT1 NFATC1 SUPT4H1 HDAC8 PPP3CB HDAC9 PPP3CC MIR943 RELA HDAC7 NFKB1 SP1 MIR1236 EP300 NELFB NFKBIA PPP3CA NELFCD NELFA PPP3R1 NELFE HDAC5 HEXIM1 NFATC2 SUPT5H PROXIMAL TUBULE TRANSPORT%WIKIPATHWAYS_20200510%WP4917%HOMO SAPIENS Proximal tubule transport SLC4A2 SLC4A4 SLC2A1 AQP1 CA2 CA4 ATP6V1E1 SLC22A11 SLC34A3 ABCC4 SLC6A19 SLC13A3 ATP6V1G1 ATP6V0B ABCC2 ATP6V0E1 SLC36A2 SLC6A18 SLC34A1 ATP1B1 SLC9A3 SLC5A8 SLC7A7 SLC7A8 ABCG2 SLC7A9 ATP6V0D2 ATP6V0C ATP6V1B1 ATP6V1A SLC47A2 SLC22A6 SLC47A1 SLC20A2 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC5A1 ATP1A1 SLC5A2 SLC6A20 SLC5A5 TMEM27 MIR6824 ATP6V1H ATP6V0A4 ATP6V1D ATP6V1C1 ATP6V1F SLC12A4 SLC16A10 FXYD2 SLC22A8 SLC22A7 SLC26A6 SLC2A2 ABCB1 EUKARYOTIC TRANSCRIPTION INITIATION%WIKIPATHWAYS_20200510%WP405%HOMO SAPIENS Eukaryotic Transcription Initiation ILK AK6 GTF2E1 GTF2E2 POLR2A POLR2B POLR2C POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K GTF2H2C_2 TAF12 TAF13 GTF2H1 GTF2H2 GTF2H3 GTF2F2 GTF2H4 CDK7 POLR3B TBP ERCC3 POLR1A POLR3D POLR1B POLR3E ERCC2 POLR1D TAF7 POLR1E TAF6 POLR3H MNAT1 POLR3K TAF5 GTF2A2 GTF2H2C CCNH GTF2B EFFECTS OF NITRIC OXIDE%WIKIPATHWAYS_20200510%WP1995%HOMO SAPIENS Effects of Nitric Oxide MB NOS3 HBA1 NOS1 AOX1 XDH NOS2 MT-CO1 GENES CONTROLLING RENAL NEPHROGENESIS%WIKIPATHWAYS_20200510%WP4823%HOMO SAPIENS Genes controlling renal nephrogenesis NOTCH2 FOXC2 ITGB1 FOXC1 RET ROBO2 SIX1 TCF21 CXCR4 HOXD11 HOXA11 NCK2 CD36 SLIT2 PDGFB NCK1 EMX2 VEGFA KIRREL FOXD1 EYA1 KDR LAMB2 LHX1 ITGA3 PAX2 CD2AP NPHS1 GDNF WT1 NPHS2 ITGA8 LMX1B CXCL12 WNT4 FGF8 PDGFRB FGFR2 AMINO ACID METABOLISM%WIKIPATHWAYS_20200510%WP3925%HOMO SAPIENS Amino Acid metabolism PNMT HIBADH VARS TAT DBH HNMT EPRS FTCD GLS AUH TDO2 P4HA2 RARS PDK4 ACADM ACAA1 OAT HADH GLUL HIBCH ARG2 SDS WARS ARG1 LDHA MARS2 PKM GPT2 MCCC1 SDHA MUT MAOA ACLY LARS2 ALDH1A1 SMS BCAT1 DLD ALDH7A1 TPH1 ADH1C PPM1L HDC ODC1 ADH7 GSR ADH5 SRM HMGCL ADH4 TPO GLUD1 CBS PCK1 DDC ACSS1 AOC3 MPST PDHA1 MDH1 GOT1 MDH2 IDH1 GOT2 TH ASNS PYCR1 FAH ASS1 CS HAL BHMT G6PC2 PC CPS1 HMGCS2 GSS CTH OGDH IARS ACO2 ALDH18A1 PDHX GCLM FH FARSB OTC DLST SUCLG1 CAD EHHADH PATHWAYS IN CLEAR CELL RENAL CELL CARCINOMA%WIKIPATHWAYS_20200510%WP4018%HOMO SAPIENS Pathways in clear cell renal cell carcinoma PLOD2 ACACB RHEB AKT1 RPTOR SLC2A1 PDGFRA EGFR SDS GPI KDM5C HK2 CREBBP SETD2 FLT1 HK3 LDHA EFCAB3 PKM BHLHE41 TPI1 ENO2 PDGFB ENO3 ARNT PGK1 MIR1281 ENO1 DEPTOR ME1 ACLY ALDOA MLST8 GAPDH HK1 KDR PGM2 PHGDH PGM1 ENPP3 CEP290 PSPH PBRM1 KSR1 TOX2 ZEB1 AKT1S1 TGFB2 CDH13 ALDOC ALDOB RAPGEF5 SQSTM1 SHMT2 SHMT1 SDSL ACACA LDHC LDHB PDGFRB LDHD PGK2 VHL MDH1 MTOR KCNJ2 PKLR PFKL PSAT1 TGFB1 MIR6778 CAMK1 SSPN TGFB3 PFKP PFKM BAP1 PTEN HIF1A VEGFA GRB10 FASN TSC2 TSC1 EP300 STAT3 DEVELOPMENT OF PULMONARY DENDRITIC CELLS AND MACROPHAGE SUBSETS%WIKIPATHWAYS_20200510%WP3892%HOMO SAPIENS Development of pulmonary dendritic cells and macrophage subsets ID2 SPI1 BATF3 CSF2 CSF1 FLT3LG IKZF1 IRF8 TCF4 TPO STAT3 RUNX2 IRF4 MONOAMINE GPCRS%WIKIPATHWAYS_20200510%WP58%HOMO SAPIENS Monoamine GPCRs DRD5 HTR1E HTR1F HTR1D HTR1B DRD3 HTR5A ADRA2B ADRB3 ADRA1D ADRB2 ADRA1B HTR1A ADRA2C HTR2C HTR2A ADRA2A ADRB1 ADRA1A DRD2 HTR4 DRD1 HTR6 HTR7 DRD4 CHRM2 CHRM3 CHRM1 CHRM4 CHRM5 HTR2B HRH1 HRH2 RETT SYNDROME CAUSING GENES%WIKIPATHWAYS_20200510%WP4312%HOMO SAPIENS Rett syndrome causing genes NCOR2 NCOR1 GNAO1 HDAC1 TCF4 MEF2C KDM5B TRRAP SATB2 SYNGAP1 FOXG1 GPS2 HTT CHD4 SYNE2 RHOBTB2 MECP2 GRIN2B CECR2 TAF1B HIVEP2 TBL1X MIR5004 GABRD SCN1A GRIN2A GABBR2 SRRM3 KCNJ10 CDKL5 EIF2B2 CRK ACTL6B SMC1A GABRA3 BRAF SMARCA1 SMARCA2 SMARCA4 XAB2 TBL1XR1 HDAC8 SCN8A IMPDH2 HAP1 SCN2A STXBP1 HDAC5 SRF AND MIRS IN SMOOTH MUSCLE DIFFERENTIATION AND PROLIFERATION%WIKIPATHWAYS_20200510%WP1991%HOMO SAPIENS SRF and miRs in Smooth Muscle Differentiation and Proliferation ELK1 MEF2D MEF2A NKX2-5 MEF2B CCND2 MIR145 CAMK2D MIR199A1 MEF2C MYOCD SRF KLF4 HEMATOPOIETIC STEM CELL GENE REGULATION BY GABP ALPHA/BETA COMPLEX%WIKIPATHWAYS_20200510%WP3657%HOMO SAPIENS Hematopoietic Stem Cell Gene Regulation by GABP alpha/beta Complex ZFX TERF2 ETV6 MIR1281 GABPA ATM SMAD4 GZMB MCL1 BCL2 SMARCA4 BCL2L1 EP300 PTEN FOXO3 DNMT1 FLT3 CREBBP DNMT3A GABPB1 DNMT3B PURINE METABOLISM%WIKIPATHWAYS_20200510%WP4792%HOMO SAPIENS Purine metabolism PRPS1 XDH ADSL AMPD1 APRT DGUOK ATIC PNP IMPDH1 HPRT1 ADSS ITPA ADA ENERGY METABOLISM%WIKIPATHWAYS_20200510%WP1541%HOMO SAPIENS Energy Metabolism MEF2D MEF2A GSK3B MEF2B PRKAG1 PPARG PRKAG2 PPARA PRKAG3 PPARD HDAC1 PRKAB2 MEF2C PRKAB1 FOXO3 CAMK2G PPARGC1B GABPA MIR1281 PPARGC1A NCOA1 NRF1 PPP3R2 ATF2 TFB1M UCP3 UCP2 PRKAA1 ESRRA MED1 PRMT1 TFB2M MAPK14 PPP3CB PPRC1 CREB1 PPP3CC SIRT1 SIRT3 CAMK4 PRKAA2 MYBBP1A TFAM EP300 PPP3CA FOXO1 PPP3R1 RXRA TCA CYCLE AND DEFICIENCY OF PYRUVATE DEHYDROGENASE COMPLEX (PDHC)%WIKIPATHWAYS_20200510%WP2453%HOMO SAPIENS TCA Cycle and Deficiency of Pyruvate Dehydrogenase complex (PDHc) IDH1 SDHA ACLY CS ACO1 DLAT IDH3A PC DLD OGDH FH DLST SUCLG2 PCK1 PDHA1 MDH1 IL-4 SIGNALING PATHWAY%WIKIPATHWAYS_20200510%WP395%HOMO SAPIENS IL-4 Signaling Pathway FLNA AKT1 IL4R JAK3 TYK2 GAB2 DOK2 CEBPA CEBPB NFIL3 INPP5D STAT6 GATA3 SOCS5 IL4 FES PIK3CD ELK1 MAPK1 MIR1281 STAT5A STAT5B BAD MAPK11 ATF2 GRB2 SOS1 IL2RG CBL FOS RPS6KB1 IRS1 PTPN11 PIK3R2 IRS2 PIK3R1 PIK3CA STAT1 PTPN6 BIRC5 CHUK MAPK14 RELA SHC1 NFKB1 IKBKB EP300 NFKBIA STAT3 JAK2 MAPK3 JAK1 SOCS3 HRH1 SOCS1 HYPOXIA-MEDIATED EMT AND STEMNESS%WIKIPATHWAYS_20200510%WP2943%HOMO SAPIENS Hypoxia-mediated EMT and Stemness DICER1 ZEB1 NEUROINFLAMMATION%WIKIPATHWAYS_20200510%WP4919%HOMO SAPIENS Neuroinflammation ASCC1 MT-CO2 NOS2 CHUK MT-CO1 FOS MAPK14 TLR4 RELA JUN NFKBIA MTOR MAPK8 THE EFFECT OF PROGERIN ON THE INVOLVED GENES IN HUTCHINSON-GILFORD PROGERIA SYNDROME%WIKIPATHWAYS_20200510%WP4320%HOMO SAPIENS The effect of progerin on the involved genes in Hutchinson-Gilford Progeria Syndrome RB1 MBD2 HIST2H3A MIR4738 HIST2H3D HIST2H3C HDAC2 HDAC1 SREBF1 TP53 LEF1 MIR3198-2 CHD4 E2F1 HIST1H3J KDM1A SUV39H1 CHD3 MTA1 HIST1H3A CBX5 RBBP4 HIST1H3F HIST1H3G INPP5K HIST1H3H HIST1H3I RBBP7 HIST1H3B MTA2 HIST1H3C MTA3 HIST1H3D HIST1H3E MBD3 H3F3B CBX3 H3F3A CBX1 WNT SIGNALING IN KIDNEY DISEASE%WIKIPATHWAYS_20200510%WP4150%HOMO SAPIENS Wnt Signaling in Kidney Disease FZD6 FZD9 FZD8 WNT2B INVS WNT5B FZD4 WNT16 WNT9B LRP5 WNT5A LRP6 MAPK9 MAPK8 WNT11 WNT7B WNT7A MIR6808 CTNNB1 MAPK10 WNT6 DVL1 RHOA DVL2 DVL3 WNT1 WNT2 MIR4683 WNT3 WNT4 FZD1 WNT10B FZD3 WNT10A FZD2 FZD5 WNT3A FZD7 PDGFR-BETA PATHWAY%WIKIPATHWAYS_20200510%WP3972%HOMO SAPIENS PDGFR-beta pathway PRKCB PRKCA RASA1 STAT6 PIK3R1 SRF EIF2AK2 PIK3CA STAT1 MAPK8 ELK1 HRAS MAP2K1 PLCG1 STAT5A STAT5B MAP2K4 MAP3K1 GRB2 SOS1 RAF1 FOS SHC1 JUN STAT3 JAK2 MAPK3 PDGFRB JAK1 FABP4 IN OVARIAN CANCER%WIKIPATHWAYS_20200510%WP4400%HOMO SAPIENS FABP4 in ovarian cancer FABP4 FGFR3 SIGNALLING IN CHONDROCYTE PROLIFERATION AND TERMINAL DIFFERENTIATION%WIKIPATHWAYS_20200510%WP4767%HOMO SAPIENS FGFR3 signalling in chondrocyte proliferation and terminal differentiation CDKN1A PTHLH PTH1R FGF9 BMP4 PPP2CA STAT1 THRA CNP NPR2 MAPK1 IHH SOX9 MAP2K1 ATG5 MAP2K2 BMP2 RBL1 SNAI1 MAPK12 MAPK13 MAPK11 RAF1 MAPK14 FGF18 MAPK3 FGFR3 TAMOXIFEN METABOLISM%WIKIPATHWAYS_20200510%WP691%HOMO SAPIENS Tamoxifen metabolism CYP3A4 CYP3A5 CYP2C19 SULT2A1 SULT1A1 CYP2C9 UGT1A4 CYP1A2 CYP2E1 CYP2A6 UGT2B15 FMO1 CYP2D6 FMO3 CYP2C8 SULT1E1 CYP1B1 UGT1A8 UGT2B7 CYP1A1 UGT1A10 FERROPTOSIS%WIKIPATHWAYS_20200510%WP4313%HOMO SAPIENS Ferroptosis STEAP3 TFRC ALOX15 SLC40A1 SAT2 ATG7 SLC7A11 SAT1 MAP1LC3B FTMT MAP1LC3C PCBP1 GCLC FTH1 GSS PCBP2 SLC39A8 GPX4 NCOA4 SLC11A2 GCLM ACSL6 ACSL5 SLC39A14 CP PRNP TF TP53 LPCAT3 ACSL1 VDAC3 VDAC2 FTL ACSL4 ACSL3 ATG5 HMOX1 CYBB SLC3A2 MAP1LC3A WNT SIGNALING%WIKIPATHWAYS_20200510%WP428%HOMO SAPIENS Wnt Signaling FZD6 FZD9 FZD8 ROCK2 FOSL1 GSK3B WNT2B CHD8 SOST KREMEN1 CAMK2B AXIN1 CAMK2D SENP2 WNT16 LEF1 LRP5 CXXC4 NKD1 NKD2 LRP6 CAMK2G MAPK9 MAPK8 WNT11 WIF1 TCF7L2 TCF7L1 RYK CSNK1A1 WNT7B WNT7A MIR6808 APC CTNNB1 NOTUM CSNK1A1L INVS PLCB1 NFATC2 NFATC4 CCND1 PRKCG PRKCB PRKCA RAC1 RHOA DAAM1 DAAM2 VANGL1 VANGL2 PLCB3 PLCB4 PRICKLE2 PRICKLE1 GPC4 PLCB2 FZD10 CCND3 FRAT1 FRAT2 CCND2 SOX17 PLAU MYC MAP3K7 CER1 WNT5B CSNK2A1 CSNK2A3 SERPINF1 CSNK2A2 CTNNBIP1 WNT5A CSNK1E DKK1 CAMK2A DKK2 DKK4 SFRP4 SFRP1 SFRP2 SFRP5 CSNK2B ROR1 ROR2 CTBP2 CTBP1 TCF7 NLK WNT6 PPP3R2 PORCN DVL1 DVL2 NFATC3 DVL3 WNT1 WNT2 NFATC1 MIR4683 WNT3 PPP3CB WNT4 PPP3CC FZD1 WNT10B JUN FZD3 PPP3CA WNT10A PPP3R1 FZD2 FZD5 WNT3A FZD7 PHOTODYNAMIC THERAPY-INDUCED HIF-1 SURVIVAL SIGNALING%WIKIPATHWAYS_20200510%WP3614%HOMO SAPIENS Photodynamic therapy-induced HIF-1 survival signaling PFKL SERPINE1 TGFB3 BCL2A1 EPO SLC2A3 PTGS2 EGLN1 IGFBP1 SLC16A1 ANGPT2 NOS2 IGFBP3 PMAIP1 BNIP3 IGFBP2 SLC2A1 TP53 TGFA LDHA HIF1AN ANGPT1 PKM HIF1A PGK1 BAK1 ARNT VEGFA BID EDN1 HK1 BIRC5 MCL1 BAX BCL2L1 BNIP3L PDHA1 LET-7 INHIBITION OF ES CELL REPROGRAMMING%WIKIPATHWAYS_20200510%WP3299%HOMO SAPIENS let-7 inhibition of ES cell reprogramming TRIM71 MYC EGR1 POU5F1 SOX2 MIRLET7F2 KLF4 MIRLET7A2 PEPTIDE GPCRS%WIKIPATHWAYS_20200510%WP24%HOMO SAPIENS Peptide GPCRs TRHR SSTR5 MC3R CCKBR FSHR CX3CR1 OPRD1 NPY4R C5AR1 OPRL1 FPR1 CXCR5 FPR3 CXCR6 FPR2 MC2R CXCR1 GALR3 GALR2 GALR1 CXCR3 CXCR2 TAC4 NTSR1 CCR10 NTSR2 CCR1 OPRK1 NMBR HCRTR2 TSHR HCRTR1 MC1R MC5R ACKR1 AGTR1 AGTR2 CXCR4 OXTR NPY6R ATP8A1 EDNRA NPY2R GRPR EDNRB BRS3 MC4R CCKAR CCR9 CCR3 C3AR1 NPY1R BDKRB2 GNRHR CCR8 BDKRB1 CCR7 CCR6 CCR5 CCR4 CCR2 GHSR LHCGR AVPR1B NPY5R AVPR2 TACR2 TACR3 OPRM1 AVPR1A TACR1 SSTR1 SSTR2 SSTR3 SSTR4 SPINAL CORD INJURY%WIKIPATHWAYS_20200510%WP2431%HOMO SAPIENS Spinal Cord Injury PTPRA CDK1 ROCK2 LEP RTN4R IL4 EGFR CDC42 MAPK1 MMP9 BDNF CDKN1B CDK2 MIR6869 NOS2 NOS1 FKBP1A ICAM1 SLIT2 SOX9 CCL2 XYLT1 AQP4 LGALS3 ZFP36 ROS1 EPHA4 GDNF SEMA6A OMG MIF PDYN BCAN MAG COL4A1 PLA2G5 PLA2G6 KLK8 RTN4 EFNB2 C5 CHST11 PLXNA2 MAPK3 MBP NGFR TNFSF13 GFAP RB1 SELP CXCL10 CSPG4 EGR1 BTG2 NCAN CXCL1 CXCL2 CCND1 LTB4R TNFSF13B PRB1 CASP3 ANXA1 MIR23B RHOC RGMA RHOB MMP12 VCAN PRKCA GAP43 COL2A1 LTB CD47 AQP1 C1QB TP53 LILRA6 AIF1 NTN1 ACAN FOXO3 PTPRZ1 SLIT1 SLIT3 CXCL8 E2F5 PLA2G2A RAC1 ARG1 E2F1 LILRB2 LILRB3 FCGR2A GJA1 APEX1 CCNG1 VIM GADD45A RHOA CDK4 FOS TLR4 NOX4 TGFB1 IL2 PTGS2 NR4A1 MYC IL1R1 IFNG CCR2 GRIN1 TNF PPP3CA TACR1 IL6 IL1A IL1B GLYCINE METABOLISM%WIKIPATHWAYS_20200510%WP1495%HOMO SAPIENS Glycine Metabolism MIR6778 SHMT2 SHMT1 MTHFR NUCLEOTIDE EXCISION REPAIR%WIKIPATHWAYS_20200510%WP4753%HOMO SAPIENS Nucleotide Excision Repair RAD23A RAD23B GTF2H5 RBX1 CUL4A DDB1 POLE4 ERCC4 RPA3 POLE2 ERCC1 POLE3 ERCC8 ERCC5 GTF2H2C_2 ERCC6 GTF2H1 GTF2H2 DDB2 GTF2H3 GTF2H4 CDK7 ERCC3 ERCC2 MNAT1 CUL4B PCNA CETN2 XPA XPC POLD3 POLD4 POLD1 POLD2 POLE RFC5 RFC3 RFC4 LIG1 RFC1 GTF2H2C RFC2 CCNH RPA1 RPA2 MODEL FOR REGULATION OF MSMP EXPRESSION IN CANCER CELLS AND ITS PROANGIOGENIC ROLE IN OVARIAN TUMORS%WIKIPATHWAYS_20200510%WP4397%HOMO SAPIENS Model for regulation of MSMP expression in cancer cells and its proangiogenic role in ovarian tumors CCR2 CTCF MSMP CIRCADIAN RHYTHM RELATED GENES%WIKIPATHWAYS_20200510%WP3594%HOMO SAPIENS Circadian rhythm related genes MC3R HNF1B NCOR1 EZH2 OPRL1 GSK3B HDAC2 HDAC1 CUL1 CPT1A NKX2-1 HCRTR2 HOMER1 HCRTR1 BHLHE41 MIR1281 DRD2 SERPINE1 HDAC3 CHRM1 NGFR EGR1 PPARG PPARA SLC9A3 NCOA2 HTR7 PRKAA1 CRH PRKAA2 GNA11 JUND ATF4 STAR GNAQ ADCY1 PPP1CC PPARGC1A DRD1 DRD4 PPP1CA CREB1 SIRT1 MYBBP1A IL6 RELB ROCK2 TNFRSF11A LEP FAS NLGN1 NFIL3 MAPK9 MAPK8 MTNR1A ARNT MTNR1B SUV39H1 MAPK10 MTA1 CCAR2 NAMPT PROK2 PTGDS BTRC MIR6883 PROK1 CCRN4L CHRNB2 UTS2R DDC METTL3 SOX14 CSNK1D CLDN4 SIK1 ATF5 CLOCK UBA52 TH TPH2 MAGED1 PRKDC DHX9 DRD3 MTTP PRKCDBP EGR3 NR1D2 NR1D1 NR2F6 SETX NMS ID4 NOS2 HNRNPD ID3 FBXL3 TOP2A SREBF1 SUV39H2 SLC6A4 PRMT5 KCND2 SFTPC PAX4 PROX1 F7 KCNMA1 AVP PHLPP1 NR1H3 AHCY CIPC ADIPOQ TYMS NTRK1 ARNTL2 ARNTL NPS CST3 PROKR2 RPS27A MIR5572 ARNT2 PASD1 PER2 PER1 PER3 GHRH AGRP GHRL LGR4 RORC RORA UBE3A RORB AHR NAGLU ADORA1 FBXW11 KCNH7 USP2 DYRK1A CARTPT PSPC1 TIMELESS UTS2 DDX5 MAGEL2 KMT2A CREM NPAS2 RAI1 AANAT UBC ZFHX3 OPN4 OPN3 NONO GFPT1 BTBD9 BHLHE40 PRKCG MIR3064 OGT KDM5A HEBP1 RBM4 DBP SIN3A TP53 SIX3 PRKG2 KLF10 SFPQ ADORA2A THRAP3 CRY2 ADA CRY1 TOP1 CRX RBM4B CIART ATOH7 NRIP1 NTRK3 PML HS3ST2 KLF9 MIR4751 MIR5047 TPH1 PRF1 CDK4 ID2 HNRNPU PTEN CSNK1E NPY2R PPP1CB CRTC1 JUN EP300 SKP1 NANOMATERIAL-INDUCED INFLAMMASOME ACTIVATION%WIKIPATHWAYS_20200510%WP3890%HOMO SAPIENS Nanomaterial-induced Inflammasome Activation TLR4 CASP1 NFKB1 NOX1 PYCARD IL1B CTSB CYSTEINE AND METHIONINE CATABOLISM%WIKIPATHWAYS_20200510%WP4504%HOMO SAPIENS Cysteine and methionine catabolism MTR MAT1A SQRDL CSAD SUOX ETHE1 BHMT CDO1 GCLC GSS CTH CBS MPST AHCY GOT1 DNA REPLICATION%WIKIPATHWAYS_20200510%WP466%HOMO SAPIENS DNA Replication DBF4 RPA4 UBA52 MCM3 CDK2 MCM4 MCM5 MCM6 MCM2 UBC RPA3 POLE2 CDC45 PCNA PRIM2 MCM7 PRIM1 GMNN POLD3 MCM10 POLD4 ORC5 POLD1 ORC4 POLD2 ORC6 POLE ORC1 RFC5 ORC3 RFC3 ORC2 RFC4 CDT1 RFC1 CDC7 RFC2 CDC6 RPA1 POLA1 RPA2 POLA2 GLIAL CELL DIFFERENTIATION%WIKIPATHWAYS_20200510%WP2276%HOMO SAPIENS Glial Cell Differentiation CNP GAP43 MAG TPPP MBP PLP1 MSN TYPE I INTERFERON INDUCTION AND SIGNALING DURING SARS-COV-2 INFECTION%WIKIPATHWAYS_20200510%WP4868%HOMO SAPIENS Type I Interferon Induction and Signaling During SARS-CoV-2 Infection IRF3 TRAF3 TYK2 TRAF6 MAP3K7 EIF2AK2 STAT1 MAPK8 TBK1 IKBKE IFNAR2 STAT2 OAS1 TREML4 OAS2 OAS3 TLR7 IRF9 IFNAR1 MYD88 CHUK FOS MAPK14 NFKB1 IKBKB JUN NFKBIA JAK1 IKBKG PI3K-AKT SIGNALING PATHWAY%WIKIPATHWAYS_20200510%WP4172%HOMO SAPIENS PI3K-Akt Signaling Pathway VWF GSK3B RPTOR STK11 MLST8 LAMC1 FGFR2 FGF10 FGFR1 THBS1 IRS1 IGF1R IFNAR2 IFNAR1 CSF1 TSC2 FLT3LG TSC1 COL4A1 TCL1B CHRM2 TCL1A MIR1181 CHRM1 C8orf44-SGK3 CDC37 DDIT4 NGFR EPHA2 LPAR2 LPAR3 EIF4EBP1 LPAR4 PIK3R6 GNG10 CD19 PDGFD PDGFC INSR PCK2 GNG11 LPAR5 LPAR6 RHEB COL9A1 COL9A3 COL9A2 IFNA5 IFNA4 IFNA7 IFNA6 MIR4260 COL2A1 IFNA1 IFNA2 IFNA8 GNGT1 GNGT2 SYK PIK3CG OSMR GYS2 KIT GYS1 PHLPP2 FIGF TNXB PKN3 RAC1 RELN IFNB1 OSM CSHL1 KITLG PDPK1 PKN2 PKN1 CSF3 CSF3R ITGA2B HSP90AA1 SGK3 TNC SGK1 COMP SGK2 IBSP TNN ATF2 TNR IL6R IFNA13 ATF6B G6PC PRKAA1 IFNA14 IL2RG IFNA16 TLR4 IFNA17 IL7 HGF IL2RA PRLR IL7R CREB3L3 PGF BCL2L1 CREB3L4 CCNE2 PRKAA2 EIF4E CREB3L1 COL4A2 CREB3L2 EIF4E1B COL4A4 COL4A3 COL4A6 CREB3 COL4A5 IFNA10 CSF1R CSH2 CSH1 EFNA5 RPS6KB1 EFNA4 RPS6KB2 VTN CREB5 ATF4 CHAD THEM4 IL2 IFNA21 GH2 EFNA1 GH1 IL3 EFNA3 G6PC3 EFNA2 GNB2 ITGA10 ITGA11 GNB4 GNB3 HSP90AB1 LAMC3 FLT4 LAMC2 GHR ITGA4 ITGA2 RBL2 COL6A2 COL6A1 IL3RA VEGFB FLT3 COL6A3 VEGFC ITGA7 ITGA6 ITGB3 COL6A6 ITGAV COL6A5 ITGA5 VEGFA EIF4E2 ITGA9 LAMA5 LAMA2 LAMA1 LAMA4 LAMA3 THBS2 PDGFA BCL2L11 THBS4 THBS3 MCL1 INS GNG3 CHUK GNG5 GNG12 GNG4 PPP2R3C GNG7 GNG8 CREB1 EIF4B ANGPT4 RELA LAMB3 NFKB1 LAMB4 IKBKB LAMB1 EPOR MIR4758 IL2RB PPP2R2D IL6 PIK3AP1 IKBKG RPS6 NTF4 NTF3 IL4R FGF1 COL1A2 FGF3 FGF4 FGF5 FGF6 FGF7 FGF9 IL4 ITGB1 PIK3CD PPP2R2A EGFR PDGFRA NRAS FLT1 AKT3 PPP2CB ANGPT1 LPAR1 MAPK1 NOS3 PDGFB HRAS PPP2R1B MAP2K1 MAP2K2 PPP2R5E PPP2R1A FGF2 ITGA1 FN1 KDR PTK2 TEK COL1A1 FGF20 PPP2R5B PPP2R5A FGF23 PPP2R5D FGF22 PPP2R3B KRAS GRB2 FGF21 SOS1 PPP2R3A RAF1 BDNF PPP2R5C PPP2R2C PPP2R2B FGF17 CDKN1B FGF14 BRCA1 FGF18 PDGFRB FGF13 FGFR3 CCNE1 FGF12 FGF11 MET GNG2 FASLG GNB1 CDK2 MDM2 NGF BCL2 PIK3R3 PIK3R2 PIK3R1 PIK3CB PPP2CA PIK3CA PHLPP1 NTRK1 NTRK2 PIK3R5 LAMB2 F2R ITGA3 GNG13 TLR2 GNB5 ITGA8 ITGB5 ITGB4 MAPK3 JAK1 ITGB8 CDKN1A ITGB7 CASP9 ITGB6 CCND1 AKT2 AKT1 JAK3 PRKCA SOS2 TP53 TGFA FOXO3 BAD EGF CDK6 CDK4 MYB PRL FGF19 PCK1 FGFR4 MTOR EPO G6PC2 CCND3 CCND2 HSP90B1 ANGPT2 MYC IGF2 MIR3652 PTEN SPP1 IGF1 FGF8 JAK2 FIBRIN COMPLEMENT RECEPTOR 3 SIGNALING PATHWAY%WIKIPATHWAYS_20200510%WP4136%HOMO SAPIENS Fibrin Complement Receptor 3 Signaling Pathway ITGAM IRF3 LY96 CXCL10 PLAT PLG CXCL3 IRAK2 IL12B LBP FGB RASSF5 FGA TICAM2 AKT1 FGG IRAK4 TICAM1 NOS2 TIRAP TYROBP TLR3 TRAF6 SRC SYK CBLB PIK3CA IFNB1 IRAK1 CCL2 MIR718 MYD88 CD14 RHOA CHUK TLR4 TNF ITGB2 NFKB1 IKBKB IL6 IKBKG PKC-GAMMA CALCIUM SIGNALING PATHWAY IN ATAXIA%WIKIPATHWAYS_20200510%WP4760%HOMO SAPIENS PKC-gamma calcium signaling pathway in ataxia CACNA1A GRM1 TRPC3 GNA15 PLCB2 ATP2B2 RYR3 GNA14 HOMER3 CA8 GNAQ GRIA3 PDK1 PRKCG PLCB1 GRIA4 ITPR1 PLCB3 PLCB4 GRIA1 GRIA2 GNA11 TRANS-SULFURATION AND ONE CARBON METABOLISM%WIKIPATHWAYS_20200510%WP2525%HOMO SAPIENS Trans-sulfuration and one carbon metabolism PSAT1 MIR6778 BHMT GCLC GSS CTH GCLM MAT2A DNMT1 AHCY DNMT3A TYMS MTR MAT1A PHGDH PSPH MTHFR AHCYL2 AHCYL1 MAT2B DNMT3L DHFRL1 MTHFD1L AMT DHFR SHMT2 MTHFD1 SHMT1 CBS MTHFD2 MTHFD2L DNMT3B DOWNREGULATION OF ACE2 EXPRESSION BY SARS-COV INFECTION AND SARS-COV SPIKE PROTEIN.%WIKIPATHWAYS_20200510%WP4799%HOMO SAPIENS Downregulation of ACE2 expression by SARS-CoV infection and SARS-CoV Spike protein. AGTR2 ACE2 ACE AGTR1 PREGNANE X RECEPTOR PATHWAY%WIKIPATHWAYS_20200510%WP2876%HOMO SAPIENS Pregnane X Receptor pathway ABCC3 CYP3A7 SRPX2 NCOA3 CYP2C9 CYP4F12 PSMC5 SRC ABCC4 ABCC2 UGT1A1 CYP3A4 CYP3A5 SLCO1B1 NRIP1 CYP2C19 UGT1A9 SULT2A1 NCOA2 UGT1A4 HSP90AA1 UGT1A3 PPARGC1A NCOA1 UGT1A6 CYP2A6 DNAJC7 GSTA2 ABCB1 NR1I2 FOXO1 RXRA CYP2B6 CHEMOKINE SIGNALING PATHWAY%WIKIPATHWAYS_20200510%WP3929%HOMO SAPIENS Chemokine signaling pathway BCAR1 PF4 ROCK2 CCL26 CX3CR1 GSK3B CXCR5 CXCR6 CXCR3 CXCR2 CCR10 PXN CCR1 PIK3CD CDC42 NRAS AKT3 MAPK1 HRAS MAP2K1 RASGRP2 PTK2 KRAS GRB2 SOS1 RAF1 ADCY2 GNG2 VAV3 GNB1 PIK3R3 PIK3R2 PIK3R1 PIK3CB PIK3CA CXCR4 STAT1 PIK3R5 STAT2 CCR3 GNG13 GNB5 PLCB1 SHC2 SHC3 SHC1 STAT3 PRKCZ MAPK3 PAK1 CXCL10 GNG10 CXCL3 AKT2 GNG11 ADCY4 ADCY3 AKT1 JAK3 ADCY7 PRKCB ADCY6 ADCY5 ADCY9 SOS2 GNGT1 GNGT2 PIK3CG FOXO3 RAC2 ARRB1 ARRB2 RAC1 STAT5B PRKCD CRK BRAF PTK2B CXCL12 PLCB3 PLCB4 GNAI2 GRK6 PLCB2 GNB2 NCF1 CXCL13 GNB4 GNB3 CXCL14 CXCL16 PREX1 TIAM2 PARD3 NFKBIB ELMO1 SHC4 GRK5 GRK4 LYN XCR1 PPBP CXCL11 ADCY1 ITK ADCY8 CXCL9 WASL CXCL5 GNAI1 CX3CL1 MIR197 RAP1B VAV1 VAV2 CCR9 FGR HCK RAP1A XCL1 PRKACG DOCK2 CCR8 CCL11 GNAI3 PRKACB CCR7 WAS CCR6 PRKX GNG3 CHUK CCL7 GNG5 TIAM1 GNG12 CCR4 GNG4 CCL5 CCR2 ADRBK1 GNG7 CCL4 CRKL CCL3 GNG8 CCL1 CSK ROCK1 RELA CCL19 NFKB1 CCL17 IKBKB CCL15 NFKBIA CCL25 CCL24 JAK2 CCL22 CCL21 CCL20 CCL28 IKBKG CCL27 MIR-124 PREDICTED INTERACTIONS WITH CELL CYCLE AND DIFFERENTIATION %WIKIPATHWAYS_20200510%WP3595%HOMO SAPIENS mir-124 predicted interactions with cell cycle and differentiation PRKAA1 STK11 PTBP1 SIX4 STRADB CTDSP1 MIR4745 ERK PATHWAY IN HUNTINGTON'S DISEASE%WIKIPATHWAYS_20200510%WP3853%HOMO SAPIENS ERK Pathway in Huntington's Disease ELK1 RPS6KA5 NTRK2 GRM1 MAPK1 MAP2K7 HRAS CASP3 EGF BDNF RAF1 CASP7 CREB1 EGFR HTT LEPTIN AND ADIPONECTIN%WIKIPATHWAYS_20200510%WP3934%HOMO SAPIENS Leptin and adiponectin PRKAA1 CPT1A LEP ACACA PRKAB1 PRKAG1 LEPR ADIPOR1 ADIPOQ ADIPOR2 NEURAL CREST CELL MIGRATION IN CANCER%WIKIPATHWAYS_20200510%WP4565%HOMO SAPIENS Neural Crest Cell Migration in Cancer PAK7 EPHB3 KIDINS220 PIK3R6 PAK6 SORT1 MMP8 F2RL2 CDH11 PAK3 NGEF PAK2 AKT2 PAK4 AKT1 MIR3620 ARF1 PIK3R3 PIK3CG PIK3CD PIK3CB PIK3CA RAC1 AKT3 NTRK2 MMP9 PIK3R5 MMP2 TRIO RHOA EPHB2 TIAM1 BDNF FOS PIK3R4 JUN STAT3 EPHB6 PAK1 TWIST1 NGFR EPHB1 EPHB4 COMPLEMENT ACTIVATION%WIKIPATHWAYS_20200510%WP545%HOMO SAPIENS Complement Activation C8G C7 C9 MASP2 MASP1 CFB CD55 C1QC CFD C1QB C1QA C1S C1R C8B CFP C5 C8A C2 C4B C3 C4A C6 EICOSANOID METABOLISM VIA LIPO OXYGENASES (LOX)%WIKIPATHWAYS_20200510%WP4721%HOMO SAPIENS Eicosanoid metabolism via Lipo Oxygenases (LOX) CYSLTR2 ALOX5 LTA4H ALOX15 GGT5 TRPA1 CYP4A11 CYP4F2 PTGR1 LTB4R PTGR2 ALOX15B CYP4F12 LTB4R2 ACOX2 ACOX1 ACOX3 DPEP1 PPARA FPR2 PPARD ACAA1 TRPV1 EHHADH CYP4A22 HPGD ALOX12 LTC4S CYSLTR1 MICRORNAS IN CARDIOMYOCYTE HYPERTROPHY%WIKIPATHWAYS_20200510%WP1544%HOMO SAPIENS MicroRNAs in cardiomyocyte hypertrophy MAP2K6 ROCK2 GSK3B CAMK2D CDK7 LRP5 PIK3CD LRP6 MAPK8 MAPK1 MAP2K1 MAP2K2 FGF2 MIR6808 CTNNB1 RAF1 TAB1 FGFR2 LIF PIK3R3 PIK3R2 PIK3R1 PIK3CB IGF1R PIK3CA MYLK IKBKE EDN1 MAP2K4 HDAC4 HDAC9 HDAC7 STAT3 MAPK3 NFATC4 MAP2K7 CDK9 MAP2K5 MIR3960 AKT2 AKT1 MAP3K14 PRKCB PIK3CG MYLK3 PLA2G2A NPPB RAC1 NPPA MIR15B IL6ST EIF2B5 PDPK1 RCAN1 MIR103A2 MIR103A1 PRKG1 MIR23A NRG1 CTF1 MIR140 EGF RHOA MAPK7 MAPK4 AGT HDAC5 MTOR MYEF2 TGFB1 PLCB2 MIR125B1 MIR125B2 MIR133B MIR199A2 MIR199A1 WNT5A GATA4 IGF1 MAP2K3 DVL1 CHUK MAPK14 PPP3CB TNF ROCK1 FZD1 NFKB1 CALM3 IKBKB CALM1 CALM2 PPP3CA FZD2 WNT3A CISH IKBKG PHOSPHODIESTERASES IN NEURONAL FUNCTION%WIKIPATHWAYS_20200510%WP4222%HOMO SAPIENS Phosphodiesterases in neuronal function ADCY4 ADCY3 ADCY7 ADCY6 GRIN2D ADCY5 ADCY9 ADORA2A GRIN2C GRIN2B DRD2 GUCY1B3 PDE4B PDE4A PDE8B PDE8A GUCY1A3 GUCY1A2 PDE4D PDE4C PDE12 PDE5A ADCY2 PDE9A PDE1C PDE1B PDE1A CHRNA7 PPP1R1B PDE11A PDE6D PDE6C PDE6B PDE6A PDE6H PDE6G PDE2A PDE10A PDE3A CHRFAM7A PDE7B PDE7A NOS1 GUCY1B2 GRIA1 ADCY1 ADCY8 GRIN2A DRD1 ADCY10 GRIN1 CREB1 PDE3B TRANSCRIPTION FACTOR REGULATION IN ADIPOGENESIS%WIKIPATHWAYS_20200510%WP3599%HOMO SAPIENS Transcription factor regulation in adipogenesis NRIP1 INSR PCK2 LEP PPARGC1A PPARG SLC2A4 CEBPD CEBPA LPIN1 CEBPB IRS1 NR3C1 CREB1 TNF IRS2 FOXO1 TWIST1 IL6 MAPK8 RXRA ADIPOQ HIPPO-YAP SIGNALING PATHWAY%WIKIPATHWAYS_20200510%WP4537%HOMO SAPIENS Hippo-Yap signaling pathway MAP4K1 CXCL10 MAP4K2 MINK1 RASSF1 TEAD1 TEAD2 TEAD3 TEAD4 MST1 YY1AP1 LATS1 NF2 NDRG1 LATS2 STK38L TNIK TAZ STK3 MAP4K3 SAV1 MAP4K4 YWHAQ FATTY ACID BETA OXIDATION%WIKIPATHWAYS_20200510%WP143%HOMO SAPIENS Fatty Acid Beta Oxidation LPL GK2 ACAT1 LIPF LIPC ACADL CPT2 SLC25A20 ACADS DECR1 CHKB HADHB HADHA GPD2 CRAT PNPLA2 ACSL6 ACSL5 CPT1A ACADM ACSL1 CPT1B HADH LIPE GK ACSL4 ACSL3 TPI1 DLD GCDH ACADVL ECHS1 ACSS2 ECI1 ALPHA 6 BETA 4 SIGNALING PATHWAY%WIKIPATHWAYS_20200510%WP244%HOMO SAPIENS Alpha 6 Beta 4 signaling pathway EIF4EBP1 AKT1 PRKCA MIR4260 IRS1 LAMC2 PTPN11 SRC PIK3R2 IRS2 PIK3R1 RAC1 ITGA6 MAPK1 HRAS LAMA5 GAB1 LAMA2 LAMA1 LAMB2 PTK2 LAMA3 PRKCD RHOA GRB2 SOS1 MAPK14 LAMC1 ITGB4 LAMB3 SHC1 LAMB1 MIR4758 MAPK3 MTOR SIGNAL TRANSDUCTION OF S1P RECEPTOR%WIKIPATHWAYS_20200510%WP26%HOMO SAPIENS Signal Transduction of S1P Receptor PLCB2 AKT2 AKT1 AKT3 MAPK1 GNAI1 MIR197 ASAH1 SMPD2 RACGAP1 S1PR1 S1PR5 MAPK12 S1PR3 SPHK2 S1PR2 SPHK1 GNAI3 PLCB1 MAPK7 MAPK6 MAPK4 PLCB3 PIK3C2B GNAI2 MAPK3 ACRYLAMIDE BIOTRANSFORMATION AND EXPOSURE BIOMARKERS%WIKIPATHWAYS_20200510%WP4233%HOMO SAPIENS Acrylamide Biotransformation and Exposure Biomarkers CYP2E1 ANGIOPOIETIN LIKE PROTEIN 8 REGULATORY PATHWAY%WIKIPATHWAYS_20200510%WP3915%HOMO SAPIENS Angiopoietin Like Protein 8 Regulatory Pathway LPL MAP2K6 GSK3B PRKAG1 PRKAG2 PRKAG3 RPTOR PRKAB2 PRKAB1 PIK3CD MAPK9 MAPK8 MAPK1 HRAS MAP2K1 MAP2K2 MLST8 MAPK12 MAPK13 MAPK10 MAPK11 SOS1 SESN3 RAF1 SLC16A2 DIO2 MAPKAP1 MLXIPL THRB EXOC7 SLCO1C1 FBP1 C19orf80 RICTOR TRIP10 SREBF1 IRS1 PIK3R3 IRS4 CBLC PIK3R2 IRS2 PIK3R1 CBLB PIK3CB RPS6KA4 PIK3CA NR1H3 RPS6KA3 RPS6KA6 THRA RPS6KA5 SREBF2 RPS6KA2 RPS6KA1 MAP3K8 SCD MAP3K9 MAP3K6 FASN MAP3K4 MAP2K4 TSC2 TSC1 SHC2 SHC3 SHC1 MAPK3 FOXO1 CYP7A1 CYP2B6 EIF4EBP1 ABCG5 MAP2K7 MAP2K5 INSR AKT2 RHEB AKT1 MAP3K10 MAP3K13 MAP3K14 MAP3K11 MAP3K12 GSK3A SLC2A1 SOS2 PIK3C2G PIK3C2A PIK3CG FOXO3 GYS1 FLOT1 FLOT2 MAP4K1 CAP1 CYP3A4 MAP4K2 PDPK1 MINK1 MAP3K5 RAPGEF1 CRK RHOQ G6PC PRKAA1 CBL ABCG8 MAPK7 MAP4K5 MAPK6 PRKAA2 EIF4E PIK3R4 PCK1 MAPK4 MAP4K3 MAP4K4 MAP3K2 MAP3K3 MTOR PTPN1 RPS6KB1 PIK3C3 RPS6KB2 MAP3K7 MAP2K3 INS MAP3K1 SLC2A4 MAPK14 RXRA FOCAL ADHESION%WIKIPATHWAYS_20200510%WP306%HOMO SAPIENS Focal Adhesion DIAPH1 BCAR1 VWF GSK3B CDC42 CTNNB1 LAMC1 VAV3 THBS1 IGF1R SHC2 COL4A1 SHC3 SHC1 PDGFD PDGFC MIR4260 COL2A1 RAC2 FIGF TNXB MYLK3 RAC1 RELN ELK1 PDPK1 RAPGEF1 ITGA2B TNC COMP IBSP TNN CRK TNR RHOA HGF PGF COL4A2 COL4A4 COL4A6 VTN CHAD ITGA10 ITGA11 LAMC3 LAMC2 ITGA4 ITGA2 COL6A2 VEGFB VEGFC ITGA7 ITGA6 ITGB3 ITGAV ITGA5 ACTB VEGFA ACTG1 ITGA9 RAP1B LAMA5 PPP1CC LAMA2 LAMA1 LAMA4 RAP1A LAMA3 THBS2 PDGFA THBS4 THBS3 PPP1CA RAC3 LAMB3 LAMB1 MIR4758 ILK ROCK2 FLNA FLNB FLNC COL1A2 ITGB1 SRC PXN PIK3CD EGFR PDGFRA MAPK9 MAPK8 FLT1 AKT3 MAPK1 PDGFB HRAS MAP2K1 ITGA1 FN1 KDR PTK2 COL1A1 MAPK10 GRB2 MIR6852 SOS1 RAF1 TLN1 PDGFRB MET ACTN1 ACTN4 MYL5 MYL7 MYL2 TLN2 BCL2 MYL9 TXK MYL12A MYL12B MYL10 PIP5K1C VASP PIK3R3 SRMS PARVA PIK3R2 PTK6 PIK3R1 PARVB MYLPF PIK3CB PARVG ARHGAP5 PIK3CA ZYX MYLK2 MYLK ARHGAP35 MYLK4 CAPN2 VCL BLK CAV3 CAV2 TNK2 CAV1 LAMB2 TNK1 ITGA3 COL5A3 COL5A2 PPP1R12A PPP1R12B PPP1R12C DOCK1 ITGA8 STYK1 ITGB5 ITGB4 MAPK3 PAK1 ITGB8 PAK6 ITGB7 ITGB6 PAK3 PAK2 CCND1 AKT2 PAK4 AKT1 PRKCG PRKCB PRKCA ERBB2 BAD EGF BRAF RASGRF1 BIRC2 CCND3 BIRC3 CCND2 XIAP FYN SHC4 PTEN SPP1 IGF1 VAV1 VAV2 FGR HCK TESK2 CRKL PPP1CB ROCK1 JUN GPCRS, CLASS C METABOTROPIC GLUTAMATE, PHEROMONE%WIKIPATHWAYS_20200510%WP501%HOMO SAPIENS GPCRs, Class C Metabotropic glutamate, pheromone GRM7 GRM1 GRM6 GRM8 GPRC5D GPRC5C GRM5 GABBR2 CASR GABBR1 MIR614 GRM3 GRM2 GPRC5B GRM4 GPRC5A CILIARY LANDSCAPE%WIKIPATHWAYS_20200510%WP4352%HOMO SAPIENS Ciliary landscape ANKS6 SNAP29 ARL8B PSMD12 PSMD13 HTRA2 SPATA7 CDH23 NEK8 TFAP2B UBE2H TFAP2C TFAP2D TFAP2E RHBDD2 HDAC2 UQCC1 NEK7 CNOT10 HDAC1 LSM4 COPS4 COPS3 IFT22 COPS6 COPS5 CNOT1 COPS2 LCN2 DYNLRB2 DYNLRB1 COPS8 DOCK5 ZMYND19 MCM8 MCM9 RPGR MIR6847 CEP170 IQCB1 EIF5B RBM14 NUP133 APC CTNNB1 DYNLT3 ARFGAP3 CEP290 RABEP2 EFHC2 CCDC40 RALB TSSC1 ANKS3 VPS4A MCM7 USH1C AGPAT2 EHBP1 MCM10 RAB21 RMND5B RMND5A DNPEP STOM SNRPB2 DCAF11 RNGTT LCA5 CEP170P1 WEE1 RAB14 MFAP1 VAPB MCM3 GLB1 MCM4 XPNPEP3 MCM5 RQCD1 MCM6 GLA MCM2 LRPPRC NDUFA9 NDUFA5 RAC1 VIM TBC1D4 CAMK2A NFKB1 CALM3 CALM1 CALM2 ECHS1 CREBBP EXOC7 TRAF3IP1 IFT172 H3F3A CEP97 IFT80 LZTFL1 IFT88 IFT81 TCTEX1D2 BBS2 BBS1 ACSL3 IFT122 FUZ IFT20 WDR60 MKS1 IFT27 TTC26 HSPB11 IFT52 BBS9 BBS7 IFT57 BBS5 BBS4 RB1 DDX5 DYNLT1 IFT140 DYNLL1 WDR34 IFT43 IFT46 MIR3064 IFT74 TTC8 TTC30B CLUAP1 MIR5047 SMC4 DCAF7 PSMD8 PSMD7 ARMC8 AFG3L2 DYNC1LI1 CBS MYL6 CD2BP2 POM121 INTU COPS7B COPS7A IQGAP1 IQGAP2 IQGAP3 NUP88 CDR2 AAR2 CTSA EXOC6B BBIP1 AIMP1 EHD3 WNK1 RANBP10 GDI1 MYL6B TNKS1BP1 NEFL TMED1 NEFM DFNB31 NINL RAB8A ZYG11B NUDC CNOT6L EXOC8 RAB3IL1 DYNLL2 NME8 EXOC4 EXOC3 EXOC6 EXOC5 MAPRE2 EXOC2 EXOC1 PAFAH1B1 YAP1 DYNC1I2 WDR26 SSNA1 EXOSC7 CTBP2 PGRMC2 EXOSC4 EXOSC9 EXOSC2 DYNC1H1 RANBP9 COX6C MKLN1 GID4 DVL3 PSMC6 PSMC4 TTC30A GID8 YPEL5 DGKE TFAP2A UBE2D2 EFTUD2 MAEA APMAP ARHGDIA RAB2A MSH2 TIPRL ERF DRUG INDUCTION OF BILE ACID PATHWAY%WIKIPATHWAYS_20200510%WP2289%HOMO SAPIENS Drug Induction of Bile Acid Pathway ABCC3 CYP3A4 SLCO1B1 NR1H4 SULT2A1 VDR SLC10A1 ABCB1 NR1I3 SLC51A ABCC4 NR1I2 BAAT ABCB11 SLC51B CYP7A1 ABCC2 PARKIN-UBIQUITIN PROTEASOMAL SYSTEM PATHWAY%WIKIPATHWAYS_20200510%WP2359%HOMO SAPIENS Parkin-Ubiquitin Proteasomal System pathway TUBA3D TUBA3C FBXW7 PSMD12 SNCA PSMD13 HSPA9 HSPA4 SIAH1 CASP8 UBE2G1 HSPA1L UBE2G2 TUBB4B SEPT5 SNCAIP TUBB4A PSMC3 PSMC1 PSMC2 HSPA1B STUB1 HSPA1A UBA1 TUBA8 CUL1 SIAH2 HSPA8 HSPA6 PSMD8 HSPA2 PSMD7 CASP1 CCNE1 PSMC5 HSPA5 UBE2L6 PARK2 UBE2L3 TUBB8 TUBA1C PSMD9 TUBB6 PSMD6 TUBA1B TUBA1A PSMD4 PSMD5 TUBB3 RNF19A PSMD2 TUBB1 PSMD3 PSMD1 PSMC6 GPR37 PSMC4 TUBB CASK TUBA4A TUBB2B TUBB2A PSMD10 PSMD11 PSMD14 TUBAL3 HSPA14 UBE2J2 UBE2J1 TUBA3E GASTRIN SIGNALING PATHWAY%WIKIPATHWAYS_20200510%WP4659%HOMO SAPIENS Gastrin Signaling Pathway RPS6 BCAR1 CCKBR GSK3B LAMTOR3 ITGB1 SRC PXN EGFR MAPK9 CDC42 MAPK8 JAG1 MAPK1 HRAS TJP1 MAP2K1 PTK2 CTNNB1 KRAS GRB2 SOS1 RAF1 ELAVL1 CDKN1B CLDN1 SERPINE1 KAT5 PRKCE PRKD2 PRKD1 ARHGEF28 SLC9A1 YES1 GAST MMP7 SERPINB2 ANXA2 RHOD TFF2 CD44 CHGA IRS1 PIK3R3 PTPN11 PIK3R2 PIK3R1 PIK3CA BMP2 PRKCH SHC1 HDAC7 STAT3 MAPK3 FOXO1 PAK1 CDH1 KLF4 EIF4EBP1 CDKN1A EGR1 CCND1 CASP3 AKT1 PPARG RHOB MAP3K11 PRKCA FOXO3 KIT CXCL8 ARRB1 ARRB2 RAC1 ELK1 PLCG1 SLC9A3 PRKCD BAD CRK CDKN2A ATF2 RHOA HDC PRKCQ FOS BCL2L1 SP1 MTOR RPS6KB1 MEF2D IL2 BIRC2 MEF2B PTGS2 BIRC3 GNAQ MYC FYN TCF4 MEF2C VEGFA BIRC5 PRKACA CHUK MAPK14 CREB1 ROCK1 RELA NFKB1 IKBKB JUN NFKBIA JAK2 SUDDEN INFANT DEATH SYNDROME (SIDS) SUSCEPTIBILITY PATHWAYS%WIKIPATHWAYS_20200510%WP706%HOMO SAPIENS Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways TCF3 HADHB HADHA HTR1A HTR2A HDAC1 CEBPB RYR2 CPT1A GATA3 YWHAG MIR16-1 HES5 CREBBP PPARGC1B PBX1 MIR1281 ALDOA GAPDH CTNNB1 NANOG BDNF NFKB2 THRB CHRNB2 DDC CHRNA4 TH TPH2 RUNX3 POU5F1 NGF ADCYAP1R1 VIPR1 VIPR2 SST SLC6A4 RET C4B AVP ECE1 C4A PLP1 PKNOX1 NTRK2 KCNH2 CHRNB4 TSPYL1 CAV3 POU3F2 AR ADCYAP1 AQP4 PRKAR1B PRKAR1A KCNQ1 DLX2 MAZ CHAT SLC1A3 GATA2 LMX1B NEUROD1 MIR210 RORA DEAF1 PRKAR2B FMO3 MAP2 PRKAR2A HDAC9 SCN3B TAC1 CHRM2 SPTBN1 NKX2-2 ESR2 PHOX2B PHOX2A PAH YWHAQ FEV SP3 CC2D1A YWHAE YWHAB CREM EGR1 MIR130A CDCA7L YBX1 FOXM1 SCN5A YWHAH NKX3-1 CASP3 SNTA1 IL10 IL13 EN1 BHLHE40 HTR3A YWHAZ NOS1AP SNAP25 SCN4B SLC25A4 ATP1A3 ASCL1 HSPD1 TF KCNJ8 ACADM NFYA TP73 MBD1 GCK REST GPD1L CXCL8 MECP2 GJA1 MAOA SLC9A3 GABRA1 TPH1 VAMP2 IL6R G6PC MYB SP1 CHRNA7 CTCF HSP90B1 CHRFAM7A GNB3 TLX3 MIR3652 MEF2C POU2F2 HES1 HIF1A VEGFA PPARGC1A PRKACA PRKACB GRIN1 NR3C1 CREB1 TNF NFKB1 EP300 JUN SOX2 IL1RN TPPP TACR1 SSTR1 IL6 SSTR2 IL1A IL1B MECP2 AND ASSOCIATED RETT SYNDROME%WIKIPATHWAYS_20200510%WP3584%HOMO SAPIENS MECP2 and Associated Rett Syndrome RPS6 YBX1 NCOR1 EZH2 AKT1 FGF3 HDAC1 FGF4 FGF5 SIN3A REST FOXG1 OPRK1 E2F1 MECP2 FGF2 SGK1 BDNF SP1 MTOR NF1 DHX9 TET1 CTCF SMC3 SST IGF2 PSIP1 GABRR2 CSRP1 MEF2C CDON GAMT PTEN RBFOX1 IGF1R GRID1 GRIA1 TET2 TAP1 CAMK2A MYT1 HNRNPH1 GPRIN1 CNP TET3 FKBP5 ARHGEF26 IGF1 DLX5 POU3F2 DLX6 TAF1L NREP FUT8 MPP1 PRPF38A FUS GAD1 POU4F1 GRIA3 BCL6 CEBPD HNRNPF GRIA4 TARDBP TAF1 MAG GRIN1 UBE3A CREB1 MBP SP3 ROLE OF OSX AND MIRNAS IN TOOTH DEVELOPMENT%WIKIPATHWAYS_20200510%WP3971%HOMO SAPIENS Role of Osx and miRNAs in tooth development BMP7 CTNNB1 NOTCH2 NOTCH3 MIR34A SOST MIR29B1 NOTCH1 MIR32 MIR145 NOTCH4 DMP1 HNF1A DSPP MIR586 MIR211 SP7 MIR143 ALPL DKK1 MIRLET7F2 KLF4 MIRLET7A2 RUNX2 ARYLAMINE METABOLISM%WIKIPATHWAYS_20200510%WP694%HOMO SAPIENS Arylamine metabolism UGT1A9 SULT1A1 UGT1A4 CYP1A2 NAT2 SULT1A2 T-CELL RECEPTOR AND CO-STIMULATORY SIGNALING%WIKIPATHWAYS_20200510%WP2583%HOMO SAPIENS T-Cell Receptor and Co-stimulatory Signaling IL2 LCK GSK3B AKT1 PDK1 FYN PRKCA RASA1 GSK3A PTEN CD28 CTLA4 ITK PTPN6 DYRK2 ZAP70 CD8B CSNK1A1 CD8A PLCG1 PDCD1 RASGRP1 NFKB1 CALM3 NFKBIA CALM1 PPP3CA CALM2 DYRK1A NFATC2 DIFFERENTIATION OF WHITE AND BROWN ADIPOCYTE %WIKIPATHWAYS_20200510%WP2895%HOMO SAPIENS Differentiation of white and brown adipocyte LEP PPARG ZNF423 CEBPA SMAD9 CEBPB SMAD5 BMP4 SMAD1 ADIPOQ BMP7 PPARGC1B BMP2 HSPB7 PPARGC1A CEBPG SLC7A10 PLAC8 PRDM16 ZIC1 HOXC9 HOXC8 MPZL2 CIDEA EBF3 TRANS-SULFURATION PATHWAY%WIKIPATHWAYS_20200510%WP2333%HOMO SAPIENS Trans-sulfuration pathway MAT2B GCLM MTR CSAD CBS MPST DNMT1 CTH AHCY GOT1 SULINDAC METABOLIC PATHWAY%WIKIPATHWAYS_20200510%WP2542%HOMO SAPIENS Sulindac Metabolic Pathway MSRA MSRB2 MSRB3 CYP1B1 CYP1A2 UREA CYCLE AND METABOLISM OF AMINO GROUPS%WIKIPATHWAYS_20200510%WP497%HOMO SAPIENS Urea cycle and metabolism of amino groups PYCR1 ASS1 PYCRL CKM ACY1 SMS GATM SARDH CPS1 ASL NAGS CKB ODC1 ALDH18A1 SRM OTC GLUD1 OAT GAMT ARG2 ARG1 CHROMOSOMAL AND MICROSATELLITE INSTABILITY IN COLORECTAL CANCER %WIKIPATHWAYS_20200510%WP4216%HOMO SAPIENS Chromosomal and microsatellite instability in colorectal cancer CDKN1A ARAF CASP9 CCND1 AKT2 REL GSK3B CASP3 AKT1 POLK APC2 AXIN1 DDB2 AXIN2 TP53 LEF1 NTN1 SMAD2 RAC2 MAPK9 MAPK8 RAC1 AKT3 TCF7L2 MAPK1 TCF7L1 MAP2K1 BAK1 CSNK1A1 APC CTNNB1 GADD45B GADD45A CSNK1A1L BAD MAPK10 RALB KRAS RHOA BRAF GADD45G TGFB2 BBC3 RAF1 BAX FOS CYCS MSH6 TGFB1 TGFB3 PTGS2 TGFBR1 MIR3191 TGFBR2 MIR3190 BCL2 PMAIP1 MYC APPL1 DCC MSH3 RALA RALGDS MLH1 EXOC2 TBK1 BIRC5 TCF7 BCL2L11 SMAD4 SMAD3 RAC3 JUN MAPK3 MSH2 EBV LMP1 SIGNALING%WIKIPATHWAYS_20200510%WP262%HOMO SAPIENS EBV LMP1 signaling IFNB1 MAPK1 IRAK1 PDLIM7 HSP90AA1 MIR718 MAP3K14 CHUK TRADD CCL5 TRAF6 MAP3K7 NFKB2 TNF RELA NFKB1 IKBKB NFKBIA MAP3K3 CXCL8 CCL20 TRAF1 MAPK8 IKBKG HFE EFFECT ON HEPCIDIN PRODUCTION%WIKIPATHWAYS_20200510%WP3924%HOMO SAPIENS Hfe effect on hepcidin production ID1 TMPRSS6 SMAD7 HFE HFE2 HAMP BMP6 MITOCHONDRIAL GENE EXPRESSION%WIKIPATHWAYS_20200510%WP391%HOMO SAPIENS Mitochondrial Gene Expression MYEF2 PPARGC1B GABPA PPARGC1A NRF1 TFB1M MTERF3 POLRMT ESRRA HCFC1 MTERF1 TFB2M PPRC1 CREB1 CAMK4 SP1 TFAM PPP3CA GABPB1 CELLS AND MOLECULES INVOLVED IN LOCAL ACUTE INFLAMMATORY RESPONSE %WIKIPATHWAYS_20200510%WP4493%HOMO SAPIENS Cells and Molecules involved in local acute inflammatory response ICAM1 SELP C7 TNF VCAM1 ITGB1 SELPLG ITGA4 ITGB2 ITGAL KNG1 C5 CXCL8 C3 IL1A IL6 C6 TYPE 2 PAPILLARY RENAL CELL CARCINOMA%WIKIPATHWAYS_20200510%WP4241%HOMO SAPIENS Type 2 papillary renal cell carcinoma PRCC DIAPH1 CTSK TGFB1 CDKN1A TCEB2 TCEB1 TGFB3 RBX1 EGLN3 EGLN2 TFE3 CADM2 TFEB COL21A1 BIRC7 EGLN1 FH SLC2A1 TGFA SFPQ CREBBP SETD2 PDGFB HIF1A ARNT VEGFA MIR1281 MIR5572 ARNT2 DVL2 TGFB2 EP300 VHL EPAS1 CUL2 ALLOGRAFT REJECTION%WIKIPATHWAYS_20200510%WP2328%HOMO SAPIENS Allograft Rejection CASP9 CASP8 IL12B CASP3 IL10 CXCR5 FAS IL13 C1QB IL21 IL4 IL22 PECR CD40 GNLY IL12A HLA-DOA PDGFRA CXCL8 HLA-DOB HLA-DPA1 BHMT2 HLA-B HLA-C HLA-A HLA-F HLA-G VIM FOXP3 HLA-E HLA-DQB1 HLA-DMA HLA-DMB HARS HLA-DQA2 HLA-DQA1 MICA HLA-DRB5 CD40LG PRF1 IL5 COL5A1 CASP7 HLA-DPB1 CXCL12 HLA-DRA IL2RA IL17A AGTR1 LRRK2 FASLG TGFB1 IL2 CXCL13 CD86 CD80 C1QA C8B CSNK2A2 C8A C2 C4B C3 STAT1 CD28 C4A CTLA4 CXCL11 C6 CXCL9 HLA-DRB1 C7 C9 GABPA VEGFA CD55 IFNG C1QC TUBA1B GDNF GZMB TNF CCL19 ABCB1 C5 PRKCZ CCL21 IL1A IL1B GLYCOSAMINOGLYCAN DEGRADATION%WIKIPATHWAYS_20200510%WP4815%HOMO SAPIENS Glycosaminoglycan degradation HYAL2 HYAL4 GLB1 IDS HPSE GUSB ARSB NAGLU HGSNAT HPSE2 IDUA HEXB HEXA GNS SGSH GALNS HYAL1 JOUBERT SYNDROME%WIKIPATHWAYS_20200510%WP4656%HOMO SAPIENS Joubert Syndrome ANKS6 FLNA NEK8 RHEB TMEM216 MRE11A ARL13B TMEM67 RAD50 TTC8 B9D1 MIR6808 CEP290 PARP1 RHOA CETN1 CEP164 CCP110 ARR3 PCM1 SUFU CSPP1 TMEM138 RP2 MTOR CEP120 ARL2 MYO6 NPHP1 NPHP3 KAT5 CEP97 NPHP4 PCNT RAB3IP ARMC9 ATF4 MYO5A PDE6D AHI1 RPGRIP1L NIN PDE6B KIAA0586 ATM PDE6A TMEM237 UNC119 PDE6G CEP41 B9D2 CEP104 ZNF423 ARL3 RAB8A INVS INPP5E PIBF1 BBS2 BBS1 TMEM231 TMEM17 MKS1 DVL1 CETN2 C5orf42 DVL3 TCTN3 SHH TCTN2 TCTN1 BBS9 BBS7 CC2D2A BBS5 BBS4 OFD1 NLR PROTEINS%WIKIPATHWAYS_20200510%WP288%HOMO SAPIENS NLR Proteins MAP3K7 ERBB2IP RELA IKBKB CD40 MAPK8 CHUK IKBKG EPHB2 DOPAMINERGIC NEUROGENESIS%WIKIPATHWAYS_20200510%WP2855%HOMO SAPIENS Dopaminergic Neurogenesis FOXA2 TGFB1 TH SLC18A2 NR4A2 EN1 ASCL1 OTX2 RET GBX2 CDKN1C ALDH1A1 GLI1 SLC6A3 MSX1 NKX6-1 PITX3 EN2 LMX1A NEUROG2 NEUROD1 LMX1B WNT1 SHH FGF8 DDC GLI2 NKX2-2 SOX2 STAT3 GENOTOXICITY PATHWAY%WIKIPATHWAYS_20200510%WP4286%HOMO SAPIENS Genotoxicity pathway LRRFIP2 RAPGEF2 TRIM22 CDKN1A PHLDA3 BTG2 IKBIP ARRDC4 AEN LCE1E TOPORS ITPKC RBM12B ACTA2 B3GNT2 HIST1H2BG HIST1H2BB HIST1H2BC AMER1 HIST1H2BN HIST1H2BM NLRX1 DDB2 HIST1H2BI PRKAB2 EI24 SEL1L RRM2B PPM1D SERTAD1 BLOC1S2 TNFRSF17 PRKAB1 E2F7 E2F8 PTGER4 PLK3 TIGAR PCDH8 CENPE MEX3B TP53I3 RPS27 SEMG2 BRMS1L DCP1B GADD45A ITPR1 DAAM1 CCP110 HIST1H3D ID2 MDM2 SMAD5 CBLB CEBPD GXYLT1 TRIAP1 TM7SF3 FBXO22 DUSP14 COIL HIST1H1E FBXL10 ENHANCEMENT OF MAP/ERK SIGNALING IN DIFFUSE LARGE B-CELL LYMPHOMA%WIKIPATHWAYS_20200510%WP4553%HOMO SAPIENS FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma HIST2H3A MIR4738 HIST2H3D HIST2H3C H2AFY2 EZH2 H2AFB1 H2AFX H2AFB2 RNF2 H2AFJ PCGF1 SUZ12 KDM2B H2AFY H2AFZ EED H2AFV MIR7107 MIR6755 BCOR H2AFB3 MAPK1 HIST1H3J HIST1H3A BCL6 HIST1H3F HIST1H3G HIST1H3H HIST1H3I HIST1H3B HIST1H3C HIST1H3D HIST1H3E MAPK3 DUSP6 H3F3B H3F3A INSULIN SIGNALLING IN HUMAN ADIPOCYTES (NORMAL CONDITION)%WIKIPATHWAYS_20200510%WP3634%HOMO SAPIENS Insulin signalling in human adipocytes (normal condition) RPS6 RPS6KB1 IRS1 TBC1D4 INSR AKT2 MTOR SLC2A4 WNT/BETA-CATENIN SIGNALING PATHWAY IN LEUKEMIA%WIKIPATHWAYS_20200510%WP3658%HOMO SAPIENS Wnt/beta-catenin Signaling Pathway in Leukemia FZD6 JUP CCND1 TCF3 GSK3B AKT1 PPARD MYC AXIN2 LEF1 LRP5 LRP6 FLT3 DKK1 WIF1 RARA CSNK1A1 PML APC CTNNB1 SALL4 RUNX1T1 ZBTB16 PYGO1 BCL9 WNT1 FRAGILE X SYNDROME %WIKIPATHWAYS_20200510%WP4549%HOMO SAPIENS Fragile X Syndrome HOXB8 TELO2 AGAP2 RAP1GAP EIF4EBP2 ARHGAP32 DLG4 AGO2 EIF4G1 GABRB2 KCNC1 TECR CLTC CLTB CLTA AP2A1 RPTOR SLC6A1 CAMK2B CYFIP1 ARC GPHN DLGAP3 MIR639 CPT1A DNM1 TTI1 FMR1 DNM2 ALDH5A1 TBC1D7 SRC PICK1 SYNGAP1 AKAP5 AP2S1 EPS8L1 AP2B1 TARBP2 HOMER1 HCN1 GRIN2B MAPK1 MAP2K1 DEPTOR MAP2K2 DICER1 CLTCL1 MMP9 MIR5004 MLST8 CNR1 SHANK1 PPP2R5B KRAS GRB2 AKT1S1 SOS1 RAF1 BDNF NF1 KCND2 PTPN11 MKNK1 PIK3CB NTRK2 PTPN5 PRKAR1A EPHA4 TSC2 TSC1 PLCB1 ABCD3 SHC1 ARAF RHEB AKT1 PDK1 PRKCA MECP2 PLCG1 GAB1 GABRD GABRA1 CDKN2A BRAF ITPR1 EIF4E MTOR CAMK1 RPS6KB1 SLC16A1 FYN PTEN GRIA1 GRIA2 CAMK2A GRM1 GRM5 GRIN2A PRKACA GAD1 PPP1CA MAP1B GRIN1 CYFIP2 CREB1 EIF4A1 SH3GL3 APP CAMK4 ABAT DUSP3 GRIP1 DAG1 AP2M1 PPP3CA SH3GL1 GRIP2 GABRG2 ALDH3A2 EEF1A1 G PROTEIN SIGNALING PATHWAYS%WIKIPATHWAYS_20200510%WP35%HOMO SAPIENS G Protein Signaling Pathways GNG10 GNG11 ADCY4 ADCY3 ADCY7 PRKCG PRKCB ADCY6 PRKCA ADCY5 ADCY9 GNGT1 GNGT2 AKAP5 NRAS HRAS GNA14 PRKCI PRKCD KRAS RHOA ITPR1 PRKCQ PDE4B GNAZ PDE4A PDE8B PDE8A PLCB3 GNAI2 PDE4D PDE4C ADCY2 GNA11 PDE1C PDE1B PRKCE PDE1A GNB1 PRKD1 SLC9A1 GNAO1 AKAP12 GNAQ AKAP13 GNB2 AKAP10 AKAP11 PDE7B PRKD3 GNB3 PDE7A AKAP9 ARHGEF1 AKAP8 AKAP7 AKAP6 AKAP4 AKAP3 AKAP2 GNA12 AKAP1 GNA13 KCNJ3 MIR7706 ADCY1 GNAL ADCY8 GNAI1 GNA15 MIR197 PRKAR1B PRKAR1A PRKACG GNG13 PRKACA GNAI3 PRKACB PRKCH RRAS GNG3 GNB5 GNG5 GNG4 GNG12 GNG7 PRKAR2B GNG8 PPP3CC PRKAR2A GNAS CALM3 CALM1 PPP3CA CALM2 PRKCZ EDA SIGNALLING IN HAIR FOLLICLE DEVELOPMENT%WIKIPATHWAYS_20200510%WP3930%HOMO SAPIENS EDA Signalling in Hair Follicle Development RELB GLI1 EDARADD BMP1 EDA PTCH1 LTB EDAR WNT3 SHH SOSTDC1 DKK1 DKK4 NANOPARTICLE TRIGGERED AUTOPHAGIC CELL DEATH%WIKIPATHWAYS_20200510%WP2509%HOMO SAPIENS Nanoparticle triggered autophagic cell death ATG14 VMP1 ULK2 CHAF1A ULK1 ATG16L1 ATG4A ATG5 ATG7 INSR INS TSC2 BCL2 TSC1 BECN1 ATG3 ATG10 SH3GLB1 UVRAG ATG9B MIR21 ATG12 AMBRA1 MAP1LC3A METHYLATION PATHWAYS%WIKIPATHWAYS_20200510%WP704%HOMO SAPIENS Methylation Pathways MAT2B COMT MAT1A MAT2A MIR4761 PNMT NNMT TPMT INMT HNMT MAMMARY GLAND DEVELOPMENT PATHWAY - PUBERTY (STAGE 2 OF 4)%WIKIPATHWAYS_20200510%WP2814%HOMO SAPIENS Mammary gland development pathway - Puberty (Stage 2 of 4) FOSL1 NRIP1 VIM FN1 TIMP1 STAT5A ESR1 CCND1 EGF PGR MYC AREG ERBB2 EXRNA MECHANISM OF ACTION AND BIOGENESIS%WIKIPATHWAYS_20200510%WP2805%HOMO SAPIENS exRNA mechanism of action and biogenesis MIR3618 ERI1 XPO5 DICER1 DROSHA AGO2 DGCR8 MIRNA BIOGENESIS%WIKIPATHWAYS_20200510%WP2338%HOMO SAPIENS miRNA Biogenesis MIR3618 XPO5 DICER1 DROSHA RAN DGCR8 TARBP2 ONCOSTATIN M SIGNALING PATHWAY%WIKIPATHWAYS_20200510%WP2374%HOMO SAPIENS Oncostatin M Signaling Pathway RPS6 EGR1 CASP3 AKT1 JAK3 TYK2 PRKCB PRKCA CEBPB TP53 CYR61 SRC PIAS3 OSMR PXN MMP1 MMP3 LIFR MMP13 MAPK9 MAPK8 MAPK1 OSM HRAS IL6ST MAP2K1 MAP2K2 TIMP3 STAT5B JUNB PRKCD KRAS GRB2 SOS1 RAF1 CASP7 PTK2B FOS CDKN1B MIR6886 LDLR RICTOR MTOR JUND SERPINE1 PRKCE CDK2 IRS1 PTPN11 PIK3R1 STAT1 HIF1A VEGFA CCL2 PRKCH MAPK14 CREB1 RELA SHC1 NFKB1 NFKBIA STAT3 JAK2 MAPK3 JAK1 SOCS3 PROSTAGLANDIN SYNTHESIS AND REGULATION%WIKIPATHWAYS_20200510%WP98%HOMO SAPIENS Prostaglandin Synthesis and Regulation PLA2G4A PTGS2 ANXA1 PPARG ANXA2 PTGER4 ABCC4 PTGFR PTGER1 PTGER2 PTGER3 EDNRA PPARGC1B EDNRB SOX9 AKR1B1 PTGS1 PTGIR HSD11B1 EDN1 HSD11B2 TBXA2R HPGDS ANXA6 PTGFRN PPARGC1A S100A10 PTGDR CBR1 PTGIS ANXA3 ANXA4 AKR1C1 ANXA5 AKR1C3 AKR1C2 PTGDS MITF SCGB1A1 TBXAS1 PRL S100A6 PTGES HPGD CYP11A1 SIGNALING OF HEPATOCYTE GROWTH FACTOR RECEPTOR%WIKIPATHWAYS_20200510%WP313%HOMO SAPIENS Signaling of Hepatocyte Growth Factor Receptor RASA1 ITGB1 PTPN11 SRC PXN PTEN PIK3CA MAPK8 ELK1 MAP4K1 MAPK1 HRAS MAP2K1 MAP2K2 RAP1B ITGA1 GAB1 PTK2 RAPGEF1 RAP1A CRK GRB2 DOCK1 SOS1 RAF1 PTK2B CRKL FOS HGF JUN STAT3 MAPK3 PAK1 MET PPAR SIGNALING PATHWAY%WIKIPATHWAYS_20200510%WP3942%HOMO SAPIENS PPAR signaling pathway ILK LPL GK2 CYP4A11 ACADL CPT2 PCK2 CYP8B1 ACOX2 ACOX1 PPARG ACOX3 PPARA PPARD ACSL6 ACSL5 CPT1A ACADM CPT1C ACAA1 CPT1B MMP1 RXRB PDPK1 ME1 RXRG PCK1 SORBS1 FADS2 HMGCS2 SLC27A1 AQP7 DBI SCP2 OLR1 APOA2 APOA1 APOA5 SLC27A6 ACSBG1 ACSL1 PLIN1 ANGPTL4 SLC27A2 ACSBG2 SLC27A5 SLC27A4 NR1H3 FABP4 UCP1 ADIPOQ ACSL4 PLTP CD36 ACSL3 APOC3 FABP1 FABP2 CYP27A1 FABP3 FABP5 FABP6 FABP7 SCD EHHADH CYP4A22 CYP7A1 RXRA PATHOGENIC ESCHERICHIA COLI INFECTION%WIKIPATHWAYS_20200510%WP2272%HOMO SAPIENS Pathogenic Escherichia coli infection ARPC1B TUBA3D ARPC1A LY96 TUBA3C ARPC5L ROCK2 CTTN NCL HCLS1 ARHGEF2 TLR5 EZR TUBB4B ARPC4 ARPC5 TUBB4A OCLN KRT18 ARPC2 ARPC3 YWHAZ TUBA8 PRKCA ITGB1 CDC42 CTNNB1 RHOA TLR4 CLDN1 FYN NCK2 WASL NCK1 ACTB TUBB8 ACTG1 TUBA1C TUBB6 TUBA1B TUBA1A TUBB3 WAS CD14 TUBB1 TUBB TUBA4A TUBB2B ROCK1 TUBB2A ABL1 TUBAL3 YWHAQ CDH1 TUBA3E DNA IR-DAMAGE AND CELLULAR RESPONSE VIA ATR%WIKIPATHWAYS_20200510%WP4016%HOMO SAPIENS DNA IR-damage and cellular response via ATR CDK1 MDC1 FOXM1 CHEK2 CHEK1 TP53BP1 NBN H2AFX MRE11A CDC25C RAD50 PPM1D RAD51 FANCD2 TP53 RAD9A DCLRE1A SMARCAL1 E2F1 FEN1 UBE2D3 CDC45 POLB HERC2 TRIM28 EXO1 UIMC1 PML MIR4741 TOPBP1 UPF1 SMARCC2 PARP1 RMI1 TOP3A RECQL HUS1 EEF1E1 MCPH1 BRCC3 BRIP1 WRN RECQL5 RBBP8 CLSPN CEP164 ATRIP BARD1 SP1 BRCA1 FANCI BRCA2 POLN XRCC5 SHFM1 PLK1 FANCA PALB2 CLK2 RAD52 TDP1 RFWD3 FAM175A CDK2 PRKDC USP1 RAD17 MDM2 RAD1 MCM2 ATR ATM MLH1 SMC1A BCL6 PCNA XPA MSH2 RPA1 IKBKG RPA2 AGE/RAGE PATHWAY%WIKIPATHWAYS_20200510%WP2324%HOMO SAPIENS AGE/RAGE pathway DIAPH1 CASP9 CASP8 INSR EZR CASP3 AKT1 IRAK4 TIRAP PRKCB PRKCA ALPL SRC SMAD2 EGFR MMP13 MAPK9 CDC42 MAPK8 RAC1 MAPK1 NOS3 MAP2K1 MMP9 STAT5A STAT5B PRKCD ATF2 RHOA RAF1 CYCS SOD1 SP1 FOXO4 PLA2G4A MMP7 NOS2 NCF1 IRS1 STAT1 MSN HIF1A MMP2 LGALS3 INS MYD88 SMAD3 CHUK DDOST MMP14 AGER MSR1 MAPK14 INHBB ROCK1 RELA SHC1 NFKB1 IKBKB JUN NFKBIA STAT3 JAK2 PRKCZ MAPK3 FOXO1 G13 SIGNALING PATHWAY%WIKIPATHWAYS_20200510%WP524%HOMO SAPIENS G13 Signaling Pathway MIR1178 DIAPH1 RHPN2 ROCK2 MYBPH RPS6KB1 CIT PFN1 PAK3 CYFIP1 ARHGEF1 PIK3R2 PIK3CD PIK3CB GNA13 PIK3CA CDC42 RAC1 WASL PKN1 TNK2 MAP3K4 MAPK10 MYL1 WAS CFL2 RHOA PPP1CB ROCK1 CALM3 CALM1 RTKN CALM2 ARHGDIG SH3RF1 CFL1 IQGAP1 ARHGDIB IQGAP2 PIP4K2A LIMK1 PI3K/AKT/MTOR - VITD3 SIGNALLING%WIKIPATHWAYS_20200510%WP4141%HOMO SAPIENS PI3K/AKT/mTOR - VitD3 Signalling SLC2A3 CYP24A1 GSK3B IL10 AKT1 TSC2 PFKFB4 TSC1 VDR MYC HLA-DRA CD86 CD80 RELA PRKAA2 IL12A PDHA1 PIK3CA MTOR RXRA HK3 LDHA NON-HOMOLOGOUS END JOINING%WIKIPATHWAYS_20200510%WP438%HOMO SAPIENS Non-homologous end joining XRCC6 WRN DCLRE1C MIR6838 XRCC4 PRKDC POLM LIG4 POLL NHEJ1 XRCC5 GANGLIO SPHINGOLIPID METABOLISM%WIKIPATHWAYS_20200510%WP1423%HOMO SAPIENS Ganglio Sphingolipid Metabolism ST8SIA1 SLC33A1 ST8SIA3 B3GALT4 FUT1 B3GALT1 ST8SIA5 ST3GAL5 B4GALNT1 A3GALT2 ST3GAL1 ST3GAL2 ST6GALNAC6 MELANOMA%WIKIPATHWAYS_20200510%WP4685%HOMO SAPIENS Melanoma RB1 CDKN1A ARAF CCND1 AKT2 AKT1 POLK LAMTOR3 DDB2 SOS2 TP53 PIK3CD KIT GRM3 RAC1 NRAS E2F1 ELK1 AKT3 E2F2 MAPK1 HRAS E2F3 MAP2K1 BAK1 MAP2K2 KDR GADD45B GADD45A BAD CDKN2A KRAS CALML5 BRAF GRB2 GADD45G CALML6 SOS1 CDK6 RAF1 CDK4 BAX FOS CALML3 MITF ERBB4 CALML4 STK19 ETS1 PREX2 NF1 MDM2 PIK3R3 PIK3R2 PIK3R1 PTEN PIK3CB PIK3CA VCL GRIN2A SHC2 CREB1 CALM3 CALM1 CALM2 MAPK3 PAK1 CDH1 FATTY ACID BIOSYNTHESIS%WIKIPATHWAYS_20200510%WP357%HOMO SAPIENS Fatty Acid Biosynthesis ACAA2 ACSL3 MECR ECH1 ACACB ECHDC1 ECHDC2 ACLY ECHDC3 SCD FASN DECR1 PC ACSL6 ACSL5 PECR ACSL1 ACACA HADH ECHS1 ACSS2 ACSL4 TRANSLATION FACTORS%WIKIPATHWAYS_20200510%WP107%HOMO SAPIENS Translation Factors EIF4EBP1 EIF4EBP2 EIF4G1 EEF2K EIF2B5 EEF2 EIF5B MIR7705 EIF2B2 EIF4E EIF4A2 EEF1B2 EIF3CL EIF2B1 EIF5A PABPC1 CLUH EIF1AY EIF1AX EEF1G EEF1D EEF1A2 ETF1 GSPT2 EIF4H EIF4EBP3 PAIP1 EIF2AK2 EIF2B4 EIF2B3 EIF2AK1 EIF2AK3 EIF2S2 EIF2S1 EIF1 EIF5 EIF2S3 EIF6 EIF3I MIR1248 EIF3J EIF3G EIF3H EIF3E EIF3F EIF3C EIF3D EIF4G3 EIF3A EIF3B EIF4B EIF4A1 EEF1A1 NON-GENOMIC ACTIONS OF 1,25 DIHYDROXYVITAMIN D3%WIKIPATHWAYS_20200510%WP4341%HOMO SAPIENS Non-genomic actions of 1,25 dihydroxyvitamin D3 RELB CYP24A1 TYK2 PRKCG PRKCB CAMK2B PRKCA CAMK2D IFNA2 IFI27L2 IFI44L CD40 PLCE1 CAMP RSAD2 TLR8 CAMK2G CXCL8 DEFB4A RXRB MAPK9 NOD2 MAPK8 NRAS ISG15 PLCG2 PLCD1 MAPK1 HRAS RXRG MAPK12 MAPK13 PRKCD MAPK11 KRAS CD40LG PRKCQ TLR4 MAPK7 NFKB2 SP1 PLCB3 PLCB4 ETS1 PLCB2 PRKCE TNFRSF1A CAMK2A STAT1 CCL2 STAT2 IFNG CAV1 OAS2 PRKCH TLR2 PLCB1 VDR MED1 MAPK14 TNF NFKB1 IKBKB JUN PRKCZ MAPK3 JAK1 IL6 CYP27B1 RXRA SP3 NEPHROTIC SYNDROME%WIKIPATHWAYS_20200510%WP4758%HOMO SAPIENS Nephrotic syndrome COQ2 INF2 MYH9 ADCK4 ACTN4 TTC21B PLCE1 CTLA4 SMARCAL1 E2F3 LAMB2 ITGA3 PAX2 CD2AP SCARB2 NPHS1 CD151 PTPRO WT1 ZMPSTE24 NPHS2 PODXL LMNA LMX1B PDSS2 GPC5 SYNPO APOL1 YARS ITGB4 CUBN TRPC6 PMM2 EMP2 WDR73 COL4A4 ARHGDIA ALG1 COL4A3 ARHGAP24 COQ6 CYP11B2 COL4A5 MYO1E ANLN ESTROGEN METABOLISM%WIKIPATHWAYS_20200510%WP697%HOMO SAPIENS Estrogen metabolism UGT1A1 ARSD CYP3A4 ARSE UGT1A9 SULT1A1 MIR4761 UGT1A3 CYP1A2 UGT1A6 NQO1 COMT SULT1E1 CYP1B1 UGT2B7 CYP1A1 GSTM1 STS GSTA1 HOST-PATHOGEN INTERACTION OF HUMAN CORONA VIRUSES - ER STRESS%WIKIPATHWAYS_20200510%WP4869%HOMO SAPIENS Host-pathogen interaction of human corona viruses - ER stress PPP1R14D XBP1 MBTPS1 CEBPA CEBPB MBTPS2 MAPK9 MAPK8 CEBPG MAPK10 ERN1 PPP1R1B ATF4 EIF2AK2 EIF2AK3 PPP1CC CEBPZ PPP1R13B PPP1R11 PPP1R10 PPP1R9A DDIT3 PPP1R9B PPP1R12A EIF2A PPP1R12B PPP1R16B PPP1R12C PPP1R16A PPP1R3G CEBPD PPP1R3F PPP1R3C PPP1CA PPP1R3B PPP1R3E PPP1CB PPP1R3D ATF6 PPP1R1A PPP1R15A PPP1R15B CEBPE PPP1R2 PPP1R3A PPP1R7 PPP1R8 PPP1R14A PPP1R14B PPP1R14C PPP1R1C NUCLEOTIDE GPCRS%WIKIPATHWAYS_20200510%WP80%HOMO SAPIENS Nucleotide GPCRs P2RY1 LPAR4 ADORA1 LTB4R ADORA2A LPAR6 P2RY6 P2RY4 ADORA2B P2RY2 ADORA3 T-CELL ANTIGEN RECEPTOR (TCR) PATHWAY DURING STAPHYLOCOCCUS AUREUS INFECTION%WIKIPATHWAYS_20200510%WP3863%HOMO SAPIENS T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection MAP2K7 LCK GSK3B AKT1 IL10 PDK1 MAP3K14 IL4 MAPK9 ZAP70 MAP2K1 CD8A DLG1 MAP2K2 PLCG1 PDCD1 CD3D GRAP2 CHP1 AHSA1 LCP2 CARD11 BCL10 MALT1 GRB2 ICOS CD40LG SOS1 CD4 IL5 RAF1 CBL PTPRC CDK4 PRKCQ LAT FOS IL2 FYN MAP3K7 PIK3CA CD28 CTLA4 ITK PTPN6 NCK1 MAP3K8 IFNG CSF2 RRAS CHUK TNF NFKB1 IKBKB CALM3 JUN NFKBIA CALM1 CALM2 MAPK3 PAK1 NFATC2 IKBKG HOST-PATHOGEN INTERACTION OF HUMAN CORONA VIRUSES - APOPTOSIS%WIKIPATHWAYS_20200510%WP4864%HOMO SAPIENS Host-pathogen interaction of human corona viruses - apoptosis FASLG CASP9 BID CASP8 MAPK12 MAPK13 CASP3 BAD BCL2L11 AKT1 MIR3191 MAPK11 MCL1 MIR3190 BCL2 BBC3 FADD CASP7 BAX MAPK14 TNF BCL2L1 APAF1 KENNEDY PATHWAY FROM SPHINGOLIPIDS%WIKIPATHWAYS_20200510%WP3933%HOMO SAPIENS Kennedy pathway from Sphingolipids PCYT1A PCYT2 CHKA PISD PTDSS2 SGPL1 PTDSS1 ETNK2 ETNK1 MIR7109 CHKB PEMT CHPT1 CEPT1 PCYT1B REGULATION OF APOPTOSIS BY PARATHYROID HORMONE-RELATED PROTEIN%WIKIPATHWAYS_20200510%WP3872%HOMO SAPIENS Regulation of Apoptosis by Parathyroid Hormone-related Protein BAK1 BID BCL2A1 GSK3B AKT1 MCL1 BCL2 MYC BAX GSK3A PTHLH BCL2L2 ITGB4 BCL2L1 BOK PIK3CG BCL2L12 BCL2L13 BCL2L10 BCL2L14 BCL2L15 ITGA6 SCFA AND SKELETAL MUSCLE SUBSTRATE METABOLISM%WIKIPATHWAYS_20200510%WP4030%HOMO SAPIENS SCFA and skeletal muscle substrate metabolism PYY FFAR3 FFAR2 GCG SLC2A4 PPARD HAIR FOLLICLE DEVELOPMENT: CYTODIFFERENTIATION (PART 3 OF 3)%WIKIPATHWAYS_20200510%WP2840%HOMO SAPIENS Hair Follicle Development: Cytodifferentiation (Part 3 of 3) MIR6510 DSG4 DSC2 DLX3 KLK5 ADAM17 KLK4 KLK7 KLK6 CUX1 TCF3 PERP LRIG1 NOTCH2 KRTAP6-1 KRTAP2-4 PROM1 ELANE NOTCH1 EGR2 GSDMA BCL11B KRTAP8-1 KLK13 KLK14 GATA3 FOXN1 KRT19 LEF1 LHX2 KRT15 GJB6 LGR5 CD200 EGFR SMAD1 WIF1 GPRC5D KITLG CTNNB1 BMPR1A FOS GLI2 TGFB1 FST RUNX3 TP63 FOSB TCF4 BMP4 WNT5A DKK1 DKK4 SFRP1 SOX9 IGF1 IFNG BMP6 MSX1 FOXE1 SMAD4 HR HOXC12 CTGF FOXQ1 CASP14 KRTAP3-3 NFATC1 PHLDA1 NR3C1 CD34 SOSTDC1 IGFBP5 RBPJ MSX2 KRTAP15-1 FZD1 NFKB1 SPINK6 SPINK5 JUN SOX2 GTPBP4 DKK3 ADAMTS20 DSG1 GAS1 S100A4 HEAD AND NECK SQUAMOUS CELL CARCINOMA%WIKIPATHWAYS_20200510%WP4674%HOMO SAPIENS Head and Neck Squamous Cell Carcinoma RB1 RPS6 EIF4EBP1 CDKN1A CASP8 CCND1 AKT2 NUMB REL RHEB AKT1 NOTCH2 RPTOR NOTCH1 STK11 TP53 PIK3CG EGFR ERBB2 NRAS E2F1 AKT3 HRAS PDPK1 GAB1 MLST8 CTNNB1 CDKN2A KRAS PRKAA1 CDK6 CDK4 MAPKAP1 NFKB2 PRKAA2 EIF4E RICTOR FGFR3 MTOR FGFR2 NFE2L2 FGFR1 TRAF3 RPS6KB2 IRF6 TP63 BIRC2 KEAP1 MIR6869 SESN2 TGFBR2 AJUBA CUL3 TERT CSMD3 FADD FAT1 FKBP1A PIK3R2 PIK3R1 PTEN PIK3CB IGF1R PIK3CA VEGFA PIK3R5 SMAD4 TSC2 TSC1 MAML1 RELA NFKB1 SESN1 DDIT4 EICOSANOID METABOLISM VIA CYCLO OXYGENASES (COX)%WIKIPATHWAYS_20200510%WP4719%HOMO SAPIENS Eicosanoid metabolism via Cyclo Oxygenases (COX) CYP4A11 CYP4F2 PTGR1 PLA2G4B PTGR2 PLA2G4A CYP4F12 PTGS2 ACOX2 ACOX1 ACOX3 PPARD ACAA1 PTGDR2 FAM213B PTGFR AKR1B1 PTGS1 PTGIR TBXA2R PTGDR PTGIS EHHADH PLA2G5 PTGDS PLA2G6 TBXAS1 PTGES CYP4A22 HPGD OSTEOCLAST SIGNALING%WIKIPATHWAYS_20200510%WP12%HOMO SAPIENS Osteoclast Signaling IFNB1 ITGB3 TRPV5 TNFRSF11B CTSK ACP5 PDGFB TNFRSF11A SLC9A1 TNFSF11 IFNAR1 ATP6V1G1 GPR68 MAPK8 AIMP2 SPP1 CELL CYCLE%WIKIPATHWAYS_20200510%WP179%HOMO SAPIENS Cell Cycle CDK1 RBX1 GSK3B HDAC2 HDAC1 CUL1 CDC25B CDK7 SMAD2 ZBTB17 CCNA1 YWHAG CDC45 MIR1281 TGFB2 MCM7 ORC5 ORC4 ORC6 CDKN1B ORC1 ORC3 ORC2 PLK1 CDC7 CCNE1 CDC6 WEE1 DBF4 CDKN2B MCM3 CDKN2C TGFB3 CDK2 MCM4 PRKDC MCM5 MDM2 MCM6 ATR MCM2 ATM MAD2L2 CDC14A RBL1 CDC14B CDKN1C CDC20 CDC23 PTTG1 PTTG2 CDC27 SKP2 ANAPC7 ANAPC4 ANAPC5 MAD1L1 ANAPC1 ANAPC2 ANAPC13 PKMYT1 ANAPC10 ANAPC11 CCNB3 CCNB2 SFN STAG1 STAG2 CDC16 YWHAQ SMC1B TFDP1 RB1 ESPL1 YWHAE TFDP2 CDKN1A YWHAB TTK FZR1 BUB3 E2F4 CCNB1 BUB1 CCND1 CHEK2 CDKN2D CHEK1 YWHAH WEE2 YWHAZ CDC25C CDC25A TP53 E2F5 E2F1 E2F2 E2F3 GADD45B GADD45A CDKN2A GADD45G CDK6 CDK4 CCNE2 TGFB1 CCND3 SMC3 CCND2 MIR3610 RAD21 MYC RBL2 CCNA2 SMAD4 SMC1A SMAD3 PCNA EP300 ABL1 SKP1 CCNH TRANSCRIPTIONAL CASCADE REGULATING ADIPOGENESIS%WIKIPATHWAYS_20200510%WP4211%HOMO SAPIENS Transcriptional cascade regulating adipogenesis DDIT3 CEBPG PPARG KLF15 KLF5 EGR2 CEBPD GATA2 CEBPA CEBPB SREBF1 GATA3 KLF2 BDNF-TRKB SIGNALING%WIKIPATHWAYS_20200510%WP3676%HOMO SAPIENS BDNF-TrkB Signaling EIF4EBP1 RPS6KB1 DLG4 RHEB AKT1 GAB2 EEF2K ARC PIK3CG MKNK1 ADCY1 NRAS HOMER1 MAPK1 NTRK2 HRAS TRPC3 MAP2K1 RPS6KA1 PLCG1 GAB1 KRAS TSC2 BRAF GRB2 TSC1 SOS1 BDNF GRIN1 CREB1 SHC1 TRPC6 MTOR GASTRIC ACID PRODUCTION%WIKIPATHWAYS_20200510%WP2596%HOMO SAPIENS Gastric acid production GRP SCT GIF CCK VIP MUC6 GAST ELECTRON TRANSPORT CHAIN (OXPHOS SYSTEM IN MITOCHONDRIA)%WIKIPATHWAYS_20200510%WP111%HOMO SAPIENS Electron Transport Chain (OXPHOS system in mitochondria) MT-ND6 MT-ND4L MT-ND4 MT-ND5 NDUFA10 ATP5G3 ATP5G2 MT-ND2 ATP5G1 MT-ND3 MT-ND1 MT-ATP6 NDUFC2 NDUFC1 ATP5F1 ATP5J2 NDUFS8 NDUFS7 NDUFS6 NDUFS5 NDUFS4 NDUFS3 NDUFS2 NDUFS1 MIR4691 ATP5S MT-CO1 NDUFB9 NDUFB8 NDUFB7 NDUFB10 NDUFB6 NDUFB5 NDUFB4 ATP5A1 NDUFB2 ATP5J NDUFB1 ATP5I ATP5H SURF1 ATP5O ATP5L ATP5B ATP5E ATP5D NDUFV3 NDUFV2 MIR7113 NDUFV1 NDUFA9 NDUFA8 NDUFA7 NDUFA6 NDUFA5 NDUFA4 NDUFA2 MT-CO2 NDUFAB1 SLC25A4 SDHA NDUFA12 ATP5C1 COX6A1 COX6A2 SDHC SDHD SDHB COX6B1 COX7A2L SCO1 UQCRC1 MT-CO3 UQCRC2 UQCRB COX15 COX17 COX7A2 COX7A1 UQCRH COX11 UQCRQ MT-CYB COX7B COX4I1 COX7C UQCRFS1 COX8A ATPIF1 SLC25A5 SLC25A14 SLC25A6 NDUFB3 UQCR11 UQCR10 UCP1 COX5B COX5A SLC25A27 NDUFA1 MT-ATP8 UCP3 COX6C UCP2 NANOMATERIAL INDUCED APOPTOSIS%WIKIPATHWAYS_20200510%WP2507%HOMO SAPIENS Nanomaterial induced apoptosis FASLG BAK1 HTRA2 CASP9 BID CASP8 CASP3 FAS DIABLO CFLAR BCL2 ENDOG PRF1 AIFM1 FADD CASP7 BAX CASP6 CYCS APAF1 TP53 NETWORK%WIKIPATHWAYS_20200510%WP1742%HOMO SAPIENS TP53 Network CDKN1A TNFSF10 MDM2 BID TP63 ATM GADD45A MIR3191 CDKN2A MIR3190 BCL2 PMAIP1 BBC3 MYC BAX SUMO1 TP53 OTX2 BOK TP73 ABL1 MITOCHONDRIAL CII ASSEMBLY%WIKIPATHWAYS_20200510%WP4920%HOMO SAPIENS Mitochondrial CII Assembly SDHC SDHD SDHB SDHA SDHAF2 SDHAF3 SDHAF1 SDHAF4 IL-3 SIGNALING PATHWAY%WIKIPATHWAYS_20200510%WP286%HOMO SAPIENS IL-3 Signaling Pathway YWHAB AKT1 GAB2 INPP5D SYK SRC PIK3CD CXCL8 IL5RA CSF2RB MAPK8 CD69 MAPK1 HRAS MAP2K1 STAT5A RAPGEF1 STAT5B ENPP3 BAD GRB2 SOS1 RAF1 CBL FOS BCL2L1 TGFB1 IL3 BCL2 FYN CD86 PTPN11 PIK3R2 PIK3R1 LYN IL3RA PTPN6 VAV1 CCR3 HCK PRKACA CRKL SHC1 JUN STAT3 JAK2 MAPK3 JAK1 YWHAQ BENZO(A)PYRENE METABOLISM%WIKIPATHWAYS_20200510%WP696%HOMO SAPIENS Benzo(a)pyrene metabolism AKR1C1 CYP3A4 AKR1C3 EPHX1 AKR1C2 AKR1A1 AKR1C4 CYP1B1 CYP1A1 COCAINE METABOLISM%WIKIPATHWAYS_20200510%WP2826%HOMO SAPIENS Cocaine metabolism CYP3A4 CES2 CES1 BCHE FOCAL ADHESION-PI3K-AKT-MTOR-SIGNALING PATHWAY%WIKIPATHWAYS_20200510%WP3932%HOMO SAPIENS Focal Adhesion-PI3K-Akt-mTOR-signaling pathway VWF CRTC2 GSK3B RPTOR STK11 STRADA PFKFB3 CAB39 MLST8 PELO CAB39L HIF3A COL11A1 COL11A2 RAB11B COL3A1 PFKFB2 AKT1S1 PFKFB1 ITGAE ITGAX LAMC1 TBC1D1 ELAVL1 ITGAD RAB10 PIK3IP1 FGFR2 FGF10 FGFR1 RAB14 THBS1 IRS1 IRS4 IRS2 IGF1R LIPE IFNAR2 IFNAR1 CSF1 TSC2 TSC1 COL4A1 TCL1B CHRM2 ITGAL TCL1A MIR1181 CHRM1 CDC37 FOXO1 DDIT4 NGFR EPHA2 EPAS1 LPAR2 LPAR3 EIF4EBP1 LPAR4 GNG10 PDGFD PDGFC INSR GNG11 LPAR5 LPAR6 RHEB IFNA7 MIR4260 COL2A1 SLC2A1 GNGT1 GNGT2 PIK3C2A PIK3CG OSMR GYS2 KIT GYS1 PHLPP2 FIGF TNXB RELN IFNB1 OSM CSHL1 KITLG PDPK1 CSF3 CSF3R ITGA2B HSP90AA1 TNC COMP IBSP TNN ATF2 TNR IL6R ATF6B PRKAA1 COL5A1 IL2RG HGF IL2RA PRLR IL7R CREB3L3 PGF CREB3L4 PRKAA2 EIF4E CREB3L1 COL4A2 ACACA CREB3L2 EIF4E1B COL4A4 COL4A6 CREB3 CSF1R CSH1 EFNA5 RPS6KB1 EFNA4 RPS6KB2 VTN CREB5 ATF4 CHAD IL2 EFNA1 EFNA3 EFNA2 GNB2 ITGA10 ITGA11 GNB4 GNB3 HSP90AB1 LAMC3 FLT4 LAMC2 GHR ITGA4 ITGA2 COL6A2 IL3RA VEGFB VEGFC ITGA7 ITGA6 ITGB3 ITGAV HIF1A ITGA5 VEGFA EIF4E2 ITGA9 LAMA5 LAMA2 LAMA1 LAMA4 LAMA3 PPARGC1A THBS2 PDGFA THBS4 THBS3 INS GNG3 GNG5 GNG12 GNG4 PPP2R3C GNG7 GNG8 CREB1 EIF4B ANGPT4 LAMB3 IKBKB LAMB1 EPOR MIR4758 IL2RB PPP2R2D IKBKG RPS6 IL4R FGF1 COL1A2 FGF3 FGF4 FGF6 FGF7 FGF9 ITGB1 PIK3CD EGFR PDGFRA NRAS FLT1 AKT3 PPP2CB ANGPT1 LPAR1 MAPK1 NOS3 PDGFB HRAS PPP2R1B MAP2K1 MAP2K2 PPP2R5E PPP2R1A FGF2 FN1 KDR PTK2 TEK COL1A1 FGF20 PPP2R5B PPP2R5A PPP2R5D FGF22 KRAS GRB2 FGF21 SOS1 PPP2R3A RAF1 PPP2R5C PPP2R2C PPP2R2B FGF17 FGF16 CDKN1B FGF14 FGF18 PIK3C2B PDGFRB FGF13 FGFR3 FGF12 FGF11 MET GNG2 GNB1 MDM2 NGF NOS2 SREBF1 NOS1 PIK3R2 PIK3R1 PIK3CB PPP2CA PIK3CA PHLPP1 SLC2A2 PIK3R5 LAMB2 F2R ITGA3 COL5A3 GNG13 COL5A2 ITGA8 ITGB5 ITGB4 ITGB2 MAPK3 JAK1 ITGB8 CDKN1A ITGB7 CASP9 ITGB6 AKT2 AKT1 JAK3 PFKFB4 FOXO3 BAD EGF PRL FGF19 PIK3R4 FGFR4 MTOR ULK1 EPO SLC2A3 HSP90B1 ANGPT2 RAB8A MIR3652 PTEN SPP1 IGF1 SLC2A4 FOXA1 FGF8 JAK2 RAB2A KETOGENESIS AND KETOLYSIS%WIKIPATHWAYS_20200510%WP4742%HOMO SAPIENS Ketogenesis and Ketolysis ACAT1 SLC2A1 CPT2 BDH1 SLC25A20 OXCT1 SLC16A1 UCP2 OXYSTEROLS DERIVED FROM CHOLESTEROL%WIKIPATHWAYS_20200510%WP4545%HOMO SAPIENS Oxysterols derived from cholesterol CYP27A1 CYP46A1 CH25H ESR1 IL25 EPHX2 DHCR7 CYP7B1 GPR183 IL17F IL17D RORC IL17C IL17B IL17A NR1H2 ESR2 CYP7A1 ONE CARBON METABOLISM%WIKIPATHWAYS_20200510%WP241%HOMO SAPIENS One Carbon Metabolism MIR6778 BHMT FTCD ATIC GART MTFMT DNMT1 ALDH1L1 MTRR AHCY GLRX DNMT3A MTHFS TYMS FOLH1 TCN2 MTR CHDH MAT1A MTHFR AHCYL2 MAT2B MTHFD1L AMT DHFR SHMT2 MTHFD1 SHMT1 MTHFD2 DNMT3B TRYPTOPHAN METABOLISM%WIKIPATHWAYS_20200510%WP465%HOMO SAPIENS Tryptophan metabolism ACAT1 AANAT CYP4F12 CYP1A2 CYP2E1 CYP7B1 INMT OGDH ALDH1A2 TDO2 AOX1 HADH WARS DHCR24 CYP3A4 ALDH1A1 MAOB TPH1 HAAO ASMT CYP19A1 HSD17B10 CYP2C18 ACMSD CYP2A13 PRMT1 ALDH2 KYNU AFMID CYP1B1 CYP2F1 CYP2J2 AOC1 CAT DDC AADAT CYP1A1 ALDH9A1 GCDH IDO1 ECHS1 ALDH3A2 GLUCOCORTICOID AND MINERALCORTICOID METABOLISM%WIKIPATHWAYS_20200510%WP237%HOMO SAPIENS Glucocorticoid and Mineralcorticoid Metabolism CYP21A2 HSD3B2 HSD3B1 HSD11B1 HSD11B2 CYP11A1 CYP11B2 CYP17A1 RELATIONSHIP BETWEEN INFLAMMATION, COX-2 AND EGFR%WIKIPATHWAYS_20200510%WP4483%HOMO SAPIENS Relationship between inflammation, COX-2 and EGFR ESR1 AKT2 PTGS2 AKT1 PTGES2 PLA1A SRC PIK3CG PIK3CD PIK3CB MMP1 PTGER4 EGFR PIK3CA PTGER1 PTGER2 NRAS PTGER3 AKT3 MAPK1 HRAS KRAS CYP19A1 BRAF MAPK3 ENDOMETRIAL CANCER%WIKIPATHWAYS_20200510%WP4155%HOMO SAPIENS Endometrial cancer ILK CDKN1A ARAF CASP9 CCND1 AKT2 GSK3B AKT1 POLK FGF1 APC2 AXIN1 DDB2 AXIN2 CTNNA3 CTNNA2 SOS2 TP53 LEF1 PIK3CD FOXO3 EGFR ERBB2 NRAS ELK1 AKT3 TCF7L2 MAPK1 TCF7L1 HRAS MAP2K1 PDPK1 BAK1 MAP2K2 FGF2 APC CTNNB1 GADD45B GADD45A BAD EGF KRAS BRAF GRB2 GADD45G SOS1 RAF1 BAX FOS FGFR3 FGFR2 FGFR1 MYC PIK3R3 PIK3R2 PIK3R1 PTEN PIK3CB PIK3CA TCF7 MAPK3 CDH1 CTNNA1 DISORDERS OF FOLATE METABOLISM AND TRANSPORT%WIKIPATHWAYS_20200510%WP4259%HOMO SAPIENS Disorders of Folate Metabolism and Transport TYMS MTR MTHFR FTCD ATIC DHFR SHMT2 MTHFD1 SLC46A1 FOLR1 GART ALDH1L1 MTHFS AUTOPHAGY%WIKIPATHWAYS_20200510%WP4923%HOMO SAPIENS Autophagy RB1CC1 ATG14 ULK1 ATG16L1 PIK3C3 ATG7 MAP1LC3B PRKAG1 PRKAG2 PRKAG3 RPTOR PRKAB2 PRKAB1 ATG101 ATG9A WIPI2 DEPTOR ATG5 MLST8 PRKAA1 AKT1S1 BECN1 PRKAA2 ATG3 PIK3R4 ATG13 UVRAG MTOR ATG12 AMBRA1 PTF1A RELATED REGULATORY PATHWAY%WIKIPATHWAYS_20200510%WP4147%HOMO SAPIENS PTF1A related regulatory pathway PDX1 RBPJL KAT2B PTF1A RBPJ CTNNB1 PROX1 NKX6-1 FGF10 NOTCH1 HES1 4-HYDROXYTAMOXIFEN, DEXAMETHASONE, AND RETINOIC ACIDS REGULATION OF P27 EXPRESSION%WIKIPATHWAYS_20200510%WP3879%HOMO SAPIENS 4-hydroxytamoxifen, Dexamethasone, and Retinoic Acids Regulation of p27 Expression EIF4EBP1 MAP2K6 MAPK1 MAP2K1 MAP2K2 MAP3K5 PBK MAP2K3 AKT1 TSC1 MAP3K11 PRKAA1 RAF1 EIF4E MKNK1 MKNK2 MAPK3 MTOR ULTRACONSERVED REGION 339 MODULATION OF TUMOR SUPPRESSOR MICRORNAS IN CANCER%WIKIPATHWAYS_20200510%WP4284%HOMO SAPIENS Ultraconserved region 339 modulation of tumor suppressor microRNAs in cancer TP53 CCNE2 MIR663B MIR95 GENES TARGETED BY MIRNAS IN ADIPOCYTES%WIKIPATHWAYS_20200510%WP1992%HOMO SAPIENS Genes targeted by miRNAs in adipocytes GJA1 IGF1 MIR133B KCNQ1 HCN4 KCNE1 MIR133A1HG PTBP2 MIR133A1 HDAC4 MIR133A2 HAND2 TMSB4X ERG HCN2 SRF KCNJ2 MIR1-1 BIOMARKERS FOR PYRIMIDINE METABOLISM DISORDERS%WIKIPATHWAYS_20200510%WP4584%HOMO SAPIENS Biomarkers for pyrimidine metabolism disorders TYMS TYMP DHODH NT5C3A NT5C DPYD TK2 UMPS CKB RRM2B RRM1 RRM2 PUS1 DPYS UPB1 GLUTATHIONE METABOLISM%WIKIPATHWAYS_20200510%WP100%HOMO SAPIENS Glutathione metabolism IDH1 GGT5 GSTT2 GGTLC2 GGTLC1 GCLC GSS GPX1 GGT1 GPX4 GPX3 OPLAH GGT2 GSR GCLM GGTLC3 GSTM2 G6PD GPX2 GSTA5 ANPEP GSTM1 GSTA1 DDX1 AS A REGULATORY COMPONENT OF THE DROSHA MICROPROCESSOR%WIKIPATHWAYS_20200510%WP2942%HOMO SAPIENS DDX1 as a regulatory component of the Drosha microprocessor MRE11A MIR3618 RAD50 DROSHA ATM DGCR8 DDX1 NBN IL-2 SIGNALING PATHWAY%WIKIPATHWAYS_20200510%WP49%HOMO SAPIENS IL-2 Signaling Pathway RPS6 RPS6KB1 RPS6KB2 IL2 LCK MAPT AKT1 JAK3 CCND2 GAB2 BCL2 MYC FYN PTPN11 SYK PIK3R1 FOXO3 STAT1 NMI MAPK1 HRAS MAP2K1 MAP2K2 STAT5A STAT5B GRB2 SOS1 CBL IL2RG RAF1 PTK2B CRKL FOS IL2RA SHC1 JUN STAT3 MAPK3 IL2RB JAK1 SOCS3 CISH HYPOTHESIZED PATHWAYS IN PATHOGENESIS OF CARDIOVASCULAR DISEASE%WIKIPATHWAYS_20200510%WP3668%HOMO SAPIENS Hypothesized Pathways in Pathogenesis of Cardiovascular Disease SERPINE1 FLNA TGFBR3 ENG LTBP1 TGFBR1 TGFBR2 ANGPT2 SMAD2 MAPK8 FBN2 MAPK1 FBN3 LTBP2 NR2C2 POSTN FBN1 SMAD4 SMAD3 CTGF MAPK14 SHC1 MAPK3 AGTR1 RUNX2 IL-10 ANTI-INFLAMMATORY SIGNALING PATHWAY %WIKIPATHWAYS_20200510%WP4495%HOMO SAPIENS IL-10 Anti-inflammatory Signaling Pathway BLVRA STAT2 HMOX1 STAT3 IL10 JAK1 IL1A IL6 IL10RB STAT1 IL10RA BLVRB DNA DAMAGE RESPONSE (ONLY ATM DEPENDENT)%WIKIPATHWAYS_20200510%WP710%HOMO SAPIENS DNA Damage Response (only ATM dependent) FOSL1 GSK3B WNT2B AXIN1 WNT16 LEF1 PIK3CD MAPK9 CDC42 MAPK8 WNT11 NRAS AKT3 TCF7L2 MAPK1 TCF7L1 HRAS PPP2R5E WNT7B WNT7A MIR6808 APC CTNNB1 MAPK10 KRAS GRB2 SOS1 PPP2R5C NFKB2 CDKN1B PIK3C2B FASLG MDM2 ATM BCL2 IRS1 PIK3R3 PIK3R2 PIK3R1 PIK3CB PIK3CA PIK3R5 MAP3K4 SHC1 CDKN1A INSR CCND1 PCK2 AKT2 AKT1 PDK1 SOS2 TP53 PIK3C2G PIK3C2A TP73 PIK3CG FOXO3 RAC2 ERBB2 RAC1 BAK1 BAD CDKN2A RHOA G6PC BBC3 BAX SOD2 MIR6886 PIK3R4 CAT LDLR TGFB1 PIK3C3 CCND3 FRAT1 MIR3191 CCND2 MIR3190 PLAU PMAIP1 SCP2 MYC MAP3K7 WNT5B RBL2 PTEN WNT5A TCF7 BCL2L11 WNT6 SMAD4 MAP3K1 DVL1 SMAD3 BCL6 DVL2 DVL3 WNT1 WNT2 WNT3 WNT4 MLKL HMGB1 RAC3 NFKB1 BIK WNT10B CCNG2 ABL1 JUN WNT10A WNT3A ACETYLCHOLINE SYNTHESIS%WIKIPATHWAYS_20200510%WP528%HOMO SAPIENS Acetylcholine Synthesis PCYT1A CHKA PEMT PDHA1 ACHE CHAT PDHA2 DUAL HIJACK MODEL OF VIF IN HIV INFECTION%WIKIPATHWAYS_20200510%WP3300%HOMO SAPIENS Dual hijack model of Vif in HIV infection CBFB CUL5 TCEB2 APOBEC3G TCEB1 RBX1 UBB RUNX1 WNT SIGNALING PATHWAY (NETPATH)%WIKIPATHWAYS_20200510%WP363%HOMO SAPIENS Wnt Signaling Pathway (Netpath) CCND1 TCF3 GSK3B SOX1 AKT1 PPARG PI4K2A CSNK1G1 PIP5K1B PRKCG GCKR PRKCB AXIN1 PRKCA GSK3A AXIN2 LEF1 LRP5 LRP6 MAPK9 MAPK8 ARRB2 RAC1 TCF7L2 MAPK1 GJA1 RYK CSNK1A1 MIR6808 APC CTNNB1 TEK RHOA CDK6 CSNK1D MTOR FRAT1 MYC MAP3K7 TCF4 CSNK1E ROR1 ROR2 CTBP1 NLK TSC2 DVL1 BCL9 TSC1 DVL2 DVL3 NFATC2 VITAMIN B12 DISORDERS%WIKIPATHWAYS_20200510%WP4271%HOMO SAPIENS Vitamin B12 Disorders TCN2 MTR MUT GIF AMN CUBN MMAA MMAB TCN1 MMACHC MMADHC CD320 MTRR MFAP5-MEDIATED OVARIAN CANCER CELL MOTILITY AND INVASIVENESS%WIKIPATHWAYS_20200510%WP3301%HOMO SAPIENS MFAP5-mediated ovarian cancer cell motility and invasiveness ITGB3 MAPK1 ITGAV TNNC1 RYR3 MFAP5 PLCG1 PTK2 PRKCQ ITPR3 CREB1 JUN MAPK3 STRUCTURAL PATHWAY OF INTERLEUKIN 1 (IL-1)%WIKIPATHWAYS_20200510%WP2637%HOMO SAPIENS Structural Pathway of Interleukin 1 (IL-1) MAP2K6 MAP2K7 IRAK2 IRAK4 MAP3K14 MAPKAPK2 MAPK9 MAPK8 ELK1 MAPK1 MAP2K1 MAP2K2 IL1RAP SAFB TANK TOLLIP MAPK10 TAB3 MAPK11 ATF2 FOS EIF4E TAB2 TAB1 MAP3K3 IRF7 MYC TRAF6 MAP3K7 NFKBIB MKNK1 MKNK2 RPS6KA5 IL1R1 IRAK1 MAP3K8 MIR718 MAP2K3 MAP2K4 MAP3K1 MYD88 CHUK MAPK14 RELA NFKB1 IKBKB NFKBIA MAPK3 MBP IL1A CYTOSOLIC DNA-SENSING PATHWAY%WIKIPATHWAYS_20200510%WP4655%HOMO SAPIENS Cytosolic DNA-sensing pathway CXCL10 CASP8 POLR2E POLR2F POLR2H RIPK1 POLR2K IFNA5 IFNA4 IFNA7 IFNA6 NLRX1 IFNA1 IFNA2 IFNA8 POLR3B POLR3D POLR3E PYCARD POLR1D ISG15 IFNB1 POLR3H POLR3K IL18 TRADD IFNA13 CCL4L2 IFNA14 ADAR IFNA16 MIR3614 IFNA17 CASP10 TRIM25 MB21D1 CASP1 ZBP1 RIPK3 DDX58 TMEM173 AIM2 RNF125 POLR1C POLR2L ATG12 IFNA10 IL33 POLR3GL IRF3 TREX1 CYLD MAVS POLR3A POLR3C POLR3F IRF7 POLR3G IFNA21 FADD NFKBIB TBK1 IKBKE ATG5 CHUK CCL5 CCL4 RELA NFKB1 IKBKB NFKBIA IL6 IKBKG IL1B SPHINGOLIPID METABOLISM (INTEGRATED PATHWAY)%WIKIPATHWAYS_20200510%WP4726%HOMO SAPIENS Sphingolipid Metabolism (integrated pathway) CERK SGMS2 SGPP2 SGPP1 UGT8 ASAH1 UGCG SGPL1 SPTLC1 SPTLC2 SMPD1 SPHK2 PPAP2B SPHK1 DEGS1 KDSR DEGS2 CERS1 CERS2 SGMS1 CERS3 CERS4 CERS5 CERS6 PHOTODYNAMIC THERAPY-INDUCED UNFOLDED PROTEIN RESPONSE%WIKIPATHWAYS_20200510%WP3613%HOMO SAPIENS Photodynamic therapy-induced unfolded protein response NARS ASNS DNAJB9 XBP1 EDEM1 UBE2E1 ATF4 PDIA6 DNAJC3 DNAJB11 ERP27 CALR MIR3191 MIR3190 HSP90B1 MIR3652 HSPA5 WARS EIF2AK3 ATF3 DDIT3 BCL2L11 EIF2A ERN1 BBC3 TRIB3 SULT1E1 ATF6 PPP1R15A NFE2L2 MFAP5 EFFECT ON PERMEABILITY AND MOTILITY OF ENDOTHELIAL CELLS VIA CYTOSKELETON REARRANGEMENT%WIKIPATHWAYS_20200510%WP4560%HOMO SAPIENS MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement ITGB3 MAPK1 ITGAV TJP1 VCL MFAP5 PLCG1 PTK2 ACTN1 MYL2 ITPR1 PRKCQ LPP CREB1 JUN PXN MAPK3 MYLK TGF-B SIGNALING IN THYROID CELLS FOR EPITHELIAL-MESENCHYMAL TRANSITION%WIKIPATHWAYS_20200510%WP3859%HOMO SAPIENS TGF-B Signaling in Thyroid Cells for Epithelial-Mesenchymal Transition TGFB1 MAPK1 ID1 VIM FN1 SNAI1 TNC AKT1 SMAD4 SMAD3 CDH6 CDH2 SNAI2 SMAD2 CDH16 MAPK3 CDH1 RUNX2 SPHINGOLIPID METABOLISM (GENERAL OVERVIEW)%WIKIPATHWAYS_20200510%WP4725%HOMO SAPIENS Sphingolipid Metabolism (general overview) CERK SGMS2 SGPP2 SGPP1 UGT8 ASAH1 UGCG SGPL1 SPTLC1 SPTLC2 SMPD1 SPHK2 PPAP2B SPHK1 DEGS1 KDSR DEGS2 CERS1 CERS2 SGMS1 CERS3 CERS4 CERS6 THERMOGENESIS%WIKIPATHWAYS_20200510%WP4321%HOMO SAPIENS Thermogenesis RPS6 CPT2 SLC25A20 PRKAG1 PRKAG2 PRKAG3 RPTOR PNPLA2 PRKAB2 CPT1A CPT1C CPT1B PRKAB1 NRAS HRAS MLST8 CNR1 MAPK12 KDM1A SMARCC2 MAPK13 MAPK11 KRAS PRDM16 FGF21 GRB2 AKT1S1 SOS1 FGFR1 ADCY2 ACSL1 LIPE RPS6KA3 RPS6KA6 ACSL4 ACSL3 RPS6KA2 RPS6KA1 ADCY10 TSC2 TSC1 ADRB3 ADCY4 RHEB ADCY3 PPARG ADCY7 ADCY6 ADCY5 ACSL6 ADCY9 ACSL5 SOS2 PRKG2 KLB SMARCB1 DPF1 DPF3 SMARCC1 FRS2 NPR1 ACTL6A MAP3K5 SIRT6 PRKG1 ARID1A ARID1B ZNF516 MGLL SMARCD1 SMARCD2 ATF2 ACTL6B KDM3A SMARCD3 KDM3B SMARCA2 PRKAA1 SLC25A29 SMARCA4 SMARCE1 BMP8A BMP8B CREB3L3 CREB3L4 PRKAA2 CREB3L1 CREB3L2 CREB3 MTOR RPS6KB1 RPS6KB2 CREB5 PLIN1 UCP1 ADCY1 ADCY8 ACTB ACTG1 GCG PRKACG PPARGC1A MAP2K3 PRKACA PRKACB MAPK14 CREB1 GNAS TYPE II INTERFERON SIGNALING (IFNG)%WIKIPATHWAYS_20200510%WP619%HOMO SAPIENS Type II interferon signaling (IFNG) CXCL10 IRF1 IRF2 CIITA SPI1 IFI6 IFIT2 HIST2H4A GBP1 NOS2 IFNGR1 IFNGR2 PSMB9 IFNA2 REG1A PTPN11 EIF2AK2 STAT1 TAP1 ISG15 IRF4 CXCL9 ICAM1 IFNB1 HLA-B STAT2 OAS1 IFNG PRKCD IRF9 IRF8 CYBB JAK2 JAK1 SOCS3 SOCS1 IL1B NO/CGMP/PKG MEDIATED NEUROPROTECTION%WIKIPATHWAYS_20200510%WP4008%HOMO SAPIENS NO/cGMP/PKG mediated Neuroprotection CASP9 DLG4 CAMK2B GRIN2D CAMK2D PRKG2 CAMK2G NPPB NPPA GRIN2C NOS3 GRIN2B NPR1 BAD CYCS GUCY1B3 GUCY1A3 GUCY1A2 PDE2A NEFL NOS2 PDE3A BCL2 XIAP NOS1 AKAP9 GUCY1B2 CNGA1 CNGA2 TSPO CNGA3 CAMK2A CNGA4 ACTN2 CNGB3 PPID CNGB1 IFNG GRIN2A GRIN1 CREB1 TNF RELA NFKB1 CALM3 NFKBIA CALM1 CALM2 IL1B PATHWAYS REGULATING HIPPO SIGNALING%WIKIPATHWAYS_20200510%WP4540%HOMO SAPIENS Pathways Regulating Hippo Signaling PRKAG1 PRKAG2 PRKAG3 PRKAB2 LEF1 PRKAB1 SMAD2 PDGFRA EGFR CDC42 FLT1 TCF7L2 TCF7L1 KDR CTNNB1 TEK CDH13 PDGFRB FGFR3 FGFR2 MET FGFR1 PRKCE CDH11 PRKD3 IGF1R GNAL NTRK1 NTRK2 PRKAR1B PRKAR1A PRKCH PLCB1 PRKAR2B PRKAR2A TAZ STK3 PRKCZ NGFR CDH1 EPHA2 INSR TEAD1 TEAD2 TEAD3 TEAD4 MST1 YY1AP1 LATS1 PRKCG PRKCB NF2 PRKCA CDH6 CDH2 CDH16 KIT RAC1 PRKCI PRKCD RHOA PRKAA1 PRKCQ PRKAA2 FGFR4 PLCB3 PLCB4 GNAI2 MTOR CSF1R GNA11 PLCB2 GNAQ FLT4 FLT3 MIR197 PRKACG TCF7 PRKACA GNAI3 CDH9 PRKACB CDH8 SMAD3 CDH7 CDH5 CDH4 CDH3 CDH20 CDH22 LATS2 CDH24 CDH10 GNAS CDH12 CDH15 CDH17 CDH18 CDH19 ANDROGEN RECEPTOR SIGNALING PATHWAY%WIKIPATHWAYS_20200510%WP138%HOMO SAPIENS Androgen receptor signaling pathway RB1 CDKN1A ROCK2 PAK6 NCOR2 FLNA NCOR1 CCND1 PIAS1 GSK3B CALR RNF14 AKT1 TGFB1I1 FHL2 EFCAB6 RHOB STUB1 PARK7 ZMIZ1 NCOA4 HDAC1 KAT7 PIAS4 SUMO1 PIAS2 ETV5 SIN3A AES PPAP2A RAN ZNF318 RAD9A FKBP4 SRC PIAS3 KLK3 RNF6 RNF4 EGFR PSMC3IP PRDX1 CDC42 BAG1 CREBBP RAC1 PATZ1 UBE2I LIMK2 KAT2B DSTN NR0B2 MIR1281 GNB2L1 CARM1 RLN1 NCOA2 PTK2 CTNNB1 KDM1A RHOA SMARCE1 SP1 BRCA1 CCNE1 KAT5 TGIF1 MDM2 NCOA3 PIK3R2 PIK3R1 PTEN DAXX NR2C2 AR CAV1 NCOA1 BMF SMAD4 SMAD3 UBE3A CREB1 SIRT1 ROCK1 RELA EP300 JUN STAT3 FOXO1 RUNX2 NOTCH1 REGULATION OF HUMAN ENDOTHELIAL CELL CALCIFICATION%WIKIPATHWAYS_20200510%WP3413%HOMO SAPIENS NOTCH1 regulation of human endothelial cell calcification JAG1 LPAR1 PLAT MIR6073 VEGFA GJA5 ITGA1 MGP CALU SAT1 SOX6 NOTCH1 DLL1 ALPL DLL3 DLL4 FGFR3 JAG2 NUCLEOTIDE-BINDING OLIGOMERIZATION DOMAIN (NOD) PATHWAY%WIKIPATHWAYS_20200510%WP1433%HOMO SAPIENS Nucleotide-binding Oligomerization Domain (NOD) pathway CASP9 CASP8 NDUFA13 NOD1 PRDM1 XIAP NLRC4 MEFV CASP5 NLRP7 NLRP4 NLRP2 NLRP1 COPS6 AAMP DUOX2 RIPK2 CARD8 CARD9 CARD6 NLRP12 ACAP1 NOD2 PYCARD NLRP10 RAC1 SUGT1 NAIP NLRP3 ERBB2IP HSP90AA1 IL18 CHUK CASP7 RELA CASP1 IKBKB NFKBIA AIM2 IKBKG IL1B INTERACTING LAMINOPATHIC PATHWAYS%WIKIPATHWAYS_20200510%WP4879%HOMO SAPIENS Interacting Laminopathic Pathways RB1 TLE1 NAP1L1 CTSK TNFRSF11B CDKN1A MIR33B AGO2 GSK3B PPARG NOTCH1 CEBPA HDAC1 AXIN1 CEBPB LEF1 SMAD2 HES5 CREBBP TARBP2 E2F1 TCF7L2 TCF7L1 KAT2B CSNK1A1 DICER1 MAOA WNT7B APC CTNNB1 CSNK1A1L JUNB ZMPSTE24 LMNA TGFB2 CDK4 TGFB1 SREBF1 MYOD1 SPP1 HES1 ACTB BMP2 TCF7 MAOB SMAD3 CEBPD MSTN FNTA EMD WNT10B TMPO MIRLET7BHG LEMD3 MIRLET7B MIR4763 ICMT RUNX2 HMGA2 CALCIUM REGULATION IN THE CARDIAC CELL%WIKIPATHWAYS_20200510%WP536%HOMO SAPIENS Calcium Regulation in the Cardiac Cell ADRA1B CAMK2B RYR2 CAMK2D CACNB1 CACNB3 GJB6 CAMK2G YWHAG CACNA1B CACNA1D CACNA1C CACNA1E CACNA1S ADCY2 GNG2 PRKCE GNB1 GJA5 PRKD1 MIR6869 FKBP1A ATP2A2 ADRB1 KCNJ3 ADRA1A CACNA1A RGS10 PRKAR1B PRKAR1A GNG13 PRKCH GNB5 PRKAR2B PRKAR2A CHRM2 CHRM3 CHRM1 SFN CHRM4 PRKCZ CHRM5 YWHAQ YWHAE YWHAB ADRB3 GNG11 YWHAH ADCY4 SLC8A1 CALR ADCY3 RGS4 ADRA1D RGS5 ADRB2 RGS2 RGS3 ADCY7 GJA3 PRKCG YWHAZ RGS1 PRKCB ADCY6 GJA4 PRKCA ADCY5 GJA9 ADCY9 GJA8 RGS9 RGS6 RGS7 GNGT1 ATP1B3 ATP1B2 STIM2 GJC1 GJC2 PKIB GJB2 GJB4 ARRB1 GJB3 ARRB2 PKIA GJB5 GJA1 PKIG RYR1 ATP2B2 ATP1B1 ATP2A3 RYR3 GJD2 CASQ2 CASQ1 RGS18 ANXA6 RGS17 RGS19 PRKCD RGS14 ATP1A4 PLN RGS20 KCNJ5 KCNB1 ITPR1 ATP2B3 PRKCQ ITPR2 ATP2B1 ITPR3 SLC8A3 RGS11 RGS16 GNAZ PLCB3 GNAI2 GNA11 GRK6 CAMK1 FXYD2 GNAO1 GNAQ GNB2 GNB4 GNB3 GRK5 GRK4 CAMK2A ADCY1 ADCY8 GNAI1 MIR197 PRKACA GNAI3 PRKACB GNG3 GNG5 GNG12 GNG4 GNG7 GJB1 GNG8 CAMK4 GNAS CALM3 CALM1 CALM2 BUTYRATE-INDUCED HISTONE ACETYLATION%WIKIPATHWAYS_20200510%WP2366%HOMO SAPIENS Butyrate-induced histone acetylation ACLY AKT1 VITAMIN D RECEPTOR PATHWAY%WIKIPATHWAYS_20200510%WP2877%HOMO SAPIENS Vitamin D Receptor Pathway ABCA11P TNFRSF11B TRPV6 TNFSF4 CYP2S1 PNOC ALPI IGSF9B KLK6 CLPTM1L TNFSF11 MXD1 ZNF257 SPRR1B ORM1 HILPDA TNFAIP3 ADRA1B TREM1 ORM2 SULT1C2 CEBPA THBD HNF1A KRTAP8-1 ADAMTS5 DNER DACT2 CA9 KRTAP5-1 ABCD1 SERPINB1 LRP5 KRTAP5-4 CAMP KRT34 CD200 CEACAM1 PTGER4 KRT38 DEFB4A COLEC11 PTH SATB1 SEMA3B ASAP2 ATP2C2 TRAK1 CST6 RASGRP1 IL1RL1 TIMP2 CST1 BGLAP TIMP3 CLMN CREG2 HSD17B2 LRRC25 FGF23 S100G KRTAP10-2 KRTAP10-4 CDX2 TGFB2 KRTAP10-7 MX2 CYP2D6 KRTAP10-9 KRT13 G0S2 MYO9B DEFB132 CDKN1B KRT16 CD9 CCNE1 EPHB4 CDKN2B CDKN2C CDK2 DUSP10 IL25 PRDM1 ID4 CASP5 PTHLH ADGRE5 STS CTLA4 TRPV5 HLA-DRB1 BMP6 S100A9 IRF8 SOSTDC1 ABCB1 KNG1 FOXO1 CYP7A1 CYP27B1 NFATC2 KLF4 CYP2B6 ITGAM ALOX5 CDKN1A CCND1 CDKN2D CYP2C9 CYP24A1 SLC8A1 ADRB2 PPARD CD40 IL12A CYP3A4 CYP3A5 NRIP1 SULT2A1 GADD45A JUNB HLA-DQA2 HLA-DQA1 CDKN2A PRKCQ ATP2B1 S100A6 CBS CYP1A1 NOX1 TGFB1 EFNA5 ID1 IRF5 IGFBP1 IGFBP3 MYC G6PD IRF4 SPP1 LPGAT1 STEAP4 SFRP1 CCNC HIF1A GXYLT2 CLDN2 LGALS9 KRT71 SLC34A2 S100A2 TPM1 SALL4 MED9 CDKAL1 LCE1F BDKRB1 ALPPL2 LCE1D CD14 BCL6 SLC2A4 LCE2B CDC34 VDR NINJ1 CASP14 MIR6872 S100A8 COL13A1 IGFBP5 CLEC16A MEG8 CRACR2A CRACR2B DND1 BTLA KRTAP4-1 KL SLC37A2 KRTAP12-2 RXRA S100A4 STAM PENTOSE PHOSPHATE METABOLISM%WIKIPATHWAYS_20200510%WP134%HOMO SAPIENS Pentose Phosphate Metabolism RPIA RPE TALDO1 PGLS G6PD PGD TKT SPLICING FACTOR NOVA REGULATED SYNAPTIC PROTEINS%WIKIPATHWAYS_20200510%WP4148%HOMO SAPIENS Splicing factor NOVA regulated synaptic proteins EFNA5 RAP1GAP GPHN CDH2 KCNMA1 EPB41 CAMK2G CLSTN1 MAPK9 CSN3 GRIK2 CHL1 EPB41L1 GRIN2B EPB41L2 SNW1 EPB41L3 MAP4 NCDN CAV2 STX2 NEO1 NTNG1 GABBR2 KCNJ6 CADM3 CADM1 APLP2 ANK3 DAB1 KCNQ2 TERF2IP AGRN ATP2B1 GRIN1 CASK STXBP2 MAPK4 PLCB4 PRKCZ CLASP1 GABRG2 MEVALONATE ARM OF CHOLESTEROL BIOSYNTHESIS PATHWAY WITH INHIBITORS%WIKIPATHWAYS_20200510%WP4189%HOMO SAPIENS Mevalonate arm of cholesterol biosynthesis pathway with inhibitors HMGCR MVD THE ALTERNATIVE PATHWAY OF FETAL ANDROGEN SYNTHESIS%WIKIPATHWAYS_20200510%WP4524%HOMO SAPIENS The alternative pathway of fetal androgen synthesis HSD3B2 AKR1C2 AKR1C4 CYB5A POR SRD5A2 HSD17B3 STAR MIR4651 CYP11A1 HSD17B6 CYP17A1 INTERACTOME OF POLYCOMB REPRESSIVE COMPLEX 2 (PRC2) %WIKIPATHWAYS_20200510%WP2916%HOMO SAPIENS Interactome of polycomb repressive complex 2 (PRC2) JARID2 EZH2 SETX AEBP2 RBBP4 MTF2 MORC3 SUZ12 ELL RBBP7 BCLAF1 STK38 TRIM35 EED EZH1 THRAP3 MIR6755 MIR-509-3P ALTERATION OF YAP1/ECM AXIS%WIKIPATHWAYS_20200510%WP3967%HOMO SAPIENS miR-509-3p alteration of YAP1/ECM axis GPC6 BCAR1 EDNRA MIR509-3 YAP1 FN1 TEAD1 TEAD2 THBS2 COL1A1 TEAD3 TEAD4 COL3A1 COL5A1 SNAI2 PBX3 TWIST1 SPARC HISTONE MODIFICATIONS%WIKIPATHWAYS_20200510%WP2369%HOMO SAPIENS Histone Modifications SMYD3 HIST1H4K KMT2A SETDB1 HIST1H4L SETD1B SETD1A SETDB2 HIST1H4A HIST1H4B HIST1H4G EZH2 HIST1H4H HIST1H4I HIST1H4J HIST1H4C HIST1H4D HIST1H4E HIST1H4F SETD2 HIST1H3J SUV39H1 HIST1H3A HIST1H3F HIST1H3G HIST1H3H HIST1H3I HIST1H3B HIST1H3C HIST1H3D HIST1H3E H3F3B H3F3A HIST2H3A MIR4738 HIST2H3D HIST2H3C AEBP2 SUV39H2 EED EZH1 MIR6755 SETD4 SUV420H2 SETD5 SETD3 SETD8 SETD9 SETD6 EHMT2 SETD7 EHMT1 PRDM2 SUV420H1 MIR555 SETMAR ASH1L SETBP1 HIST4H4 KMT2E KMT2D SET SMYD5 KMT2C DOT1L KMT2B NSD1 SMYD2 SMYD1 SMYD4 THYROID HORMONES PRODUCTION AND THEIR PERIPHERAL DOWNSTREAM SIGNALLING EFFECTS REGARDING CONGENITAL HYPOTHYROIDISM%WIKIPATHWAYS_20200510%WP4746%HOMO SAPIENS Thyroid hormones production and their peripheral downstream signalling effects regarding congenital hypothyroidism RPS6 CASP9 ADRB3 GSK3B ADCY3 RHEB PPARG RPTOR NOTCH1 PNPLA2 TP53 PRKG2 SRC MAPKAPK3 KLB TSHR NPPB AKT3 NPPA MAPK1 HRAS MAP2K1 FRS2 NPR1 MLST8 SIRT6 TBC1D4 CTNNB1 KDM1A ZNF516 MGLL BAD ATF2 ACTL6B PRDM16 FGF21 GRB2 KDM3B AKT1S1 SOS1 PFKFB2 TRH RAF1 TTF2 SLC16A2 PRKCQ ITPR2 TTF1 DIO2 NHSL1 IYD MAP4K5 THRB DUOXA2 TPO TSHB SECISBP2L SLCO1C1 DIO1 DIO3 SLC5A5 PAX8 CREB3 TG MTOR SLC26A4 FGFR1 RPS6KB1 SLC16A10 MDM2 POMC AQP7 DUOX2 PLIN1 PIK3CA UCP1 THRA RPS6KA6 ADCY8 ITGB3 ITGAV MAFA NPY MC4R PPARGC1A PRKACA TSC2 AGRP TSC1 PLCB1 MAPK14 SHH WNT4 FOXO1 RXRA NRF2 PATHWAY%WIKIPATHWAYS_20200510%WP2884%HOMO SAPIENS NRF2 pathway HSPA1A SLC6A1 PRDX1 PDGFB ME1 TGFB2 SQSTM1 FGF13 SLC2A12 SLC39A9 KEAP1 SLC39A6 SLC39A5 TGFBR2 SLC39A7 SLC39A2 SLC39A1 SLC39A4 SLC39A3 SLC6A17 SLC6A16 SLC6A4 SLC6A15 SLC6A14 SLC6A13 SLC6A11 SLC5A6 SLC5A7 ALDH3A1 SLC5A9 CES3 GSTM1 EPHA3 MGST3 GSTA1 MGST2 TXN CES5A SLC2A2 SLC5A3 SLC5A4 GSTM4 GSTM3 PRDX6 SLC2A9 SLC6A5 SLC6A3 SLC6A6 SLC6A7 SLC6A8 SLC6A9 MAFG MAFF GSTM5 SERPINA1 AGER SRXN1 SLC2A5 SLC2A6 SLC6A2 SLC2A7 SLC2A8 SLC2A14 UGT2B7 SLC2A11 CYP4A22 SLC2A10 ABCC5 SLC2A13 SLC39A11 EPHA2 SLC39A10 SLC39A13 ABCC3 SLC39A12 CES4A GSTP1 EGR1 SLC5A11 CYP4A11 SLC5A12 SLC5A10 SLC7A11 PTGR1 DNAJB1 UGT1A7 CBR3 TXNRD3 GSTA4 GSTA3 FTH1 SLC39A8 PPARD PGD SLC39A14 SLC2A1 TGFA FTL ABCC4 SLC6A19 ABCC2 UGT1A1 SLC6A18 UGT1A9 SLC5A8 CES2 GSTT2 CES1 HSP90AA1 HMOX1 NRG1 CBR1 UGT1A6 NQO1 GPX3 TXNRD1 ADH7 GSR HGF SOD3 SLC5A1 SLC5A2 SLC6A20 SLC5A5 NFE2L2 TGFB1 GGTLC2 SLC2A3 GGTLC1 GCLC GGT1 GGT2 GCLM GGTLC3 HSP90AB1 GSTM2 G6PD GPX2 GSTA5 UGT1A4 HBEGF UGT1A3 SLC2A4 CYP2A6 BLVRB GSTA2 RXRA NEUROTRANSMITTER DISORDERS%WIKIPATHWAYS_20200510%WP4220%HOMO SAPIENS Neurotransmitter Disorders TH MAOA DDC DBH BLADDER CANCER%WIKIPATHWAYS_20200510%WP2828%HOMO SAPIENS Bladder Cancer RB1 TYMP CDKN1A ARAF RASSF1 MDM2 CCND1 THBS1 DAPK1 MYC DAPK2 DAPK3 MIR637 UPK3A TP53 SRC PIK3R2 PIK3R1 MMP1 EGFR CXCL8 ERBB2 NRAS E2F1 RPS6KA5 MAPK1 HRAS MAP2K1 VEGFA MAP2K2 MMP9 MMP2 HBEGF CDKN2A EGF KRAS BRAF CDK4 RAF1 FGFR3 CDH1 TYPE III INTERFERON SIGNALING%WIKIPATHWAYS_20200510%WP2113%HOMO SAPIENS Type III interferon signaling STAT2 IFNL2 IFNL1 IFNLR1 IRF9 IFNL3 JAK1 IL10RB STAT1 TYK2 MAMMARY GLAND DEVELOPMENT PATHWAY - PREGNANCY AND LACTATION (STAGE 3 OF 4)%WIKIPATHWAYS_20200510%WP2817%HOMO SAPIENS Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4) ERBB3 TNFRSF11A CCND1 ESR1 TNFSF11 CEBPA PGR CEBPB MYC EGFR GJB2 ERBB2 PNCK ATP2C2 CSN2 YY1 TPM3 USF2 TTC9 CAV1 GAL ELF5 CHUK NR3C1 ERBB4 PRLR BCL2L1 PRL EIF4E ESR2 JAK2 PTPN1 GASTRIC CANCER NETWORK 2%WIKIPATHWAYS_20200510%WP2363%HOMO SAPIENS Gastric Cancer Network 2 SNURF CD48 RAD17 COL9A1 COL9A3 LBR MYC TOP2A TP53 EGFR CEBPZ CTNNB1 PLAC8 OTUD5 AHCTF1 DSCC1 CHTF18 LMNB2 MTDH CHTF8 S100A6 BRIX1 FANCI RFC3 UBE2C RFC4 ATAD2 CACYBP FAM91A1 RNF144B UBE2T MIR7108 LTF DANGER SIGNAL RESPONSE PATHWAY%WIKIPATHWAYS_20200510%WP4478%HOMO SAPIENS LTF danger signal response pathway IFNB1 MAPK1 IRAK1 MIR718 IRAK4 MYD88 TREM1 CD14 TLR2 TRAF6 AGER IFNA1 TLR4 LTF TNF NFKB1 CXCL8 IL1A IL6 IL1B BASE EXCISION REPAIR%WIKIPATHWAYS_20200510%WP4752%HOMO SAPIENS Base Excision Repair POLE4 POLE2 POLE3 MPG PNKP OGG1 POLL UNG NTHL1 TDG MUTYH MBD4 PARP2 APEX2 XRCC1 FEN1 LIG3 SMUG1 POLB NEIL3 APEX1 NEIL2 PARP1 PCNA POLD3 POLD4 POLD1 HMGB1 POLD2 POLE LIG1 CYTOSINE METHYLATION%WIKIPATHWAYS_20200510%WP3585%HOMO SAPIENS Cytosine methylation IDH1 MECP2 TET3 IDH2 TET1 TDG MBD3 DNMT1 TET2 ENDOCHONDRAL OSSIFICATION WITH SKELETAL DYSPLASIAS%WIKIPATHWAYS_20200510%WP4808%HOMO SAPIENS Endochondral Ossification with Skeletal Dysplasias PLAT SERPINH1 AKT1 ADAMTS5 COL2A1 ALPL ACAN CAB39 MMP13 PTH BMP7 MMP9 FGF2 TIMP3 STAT5B BMPR1A TGFB2 CTSV GLI3 ADAMTS4 ADAMTS1 FGF18 COL10A1 NKX3-2 SOX5 DDR2 FGFR3 CST5 SCIN FRZB FGFR1 SLC38A2 TGFB1 MIR6073 MGP RUNX3 SOX6 IFT88 GH1 PLAU IGF2 PTHLH HMGCS1 PTH1R GHR MEF2C IGF1R STAT1 THRA SPP1 IHH SOX9 IGF1 VEGFA ENPP1 CDKN1C BMP6 PRKACA HDAC4 PTCH1 CALM3 CALM1 CHST11 CALM2 RUNX2 KIF3A COMPLEMENT AND COAGULATION CASCADES%WIKIPATHWAYS_20200510%WP558%HOMO SAPIENS Complement and Coagulation Cascades PLAT VWF F3 PLG FGB C5AR1 CLTC THBD C1QB SERPIND1 SERPINE1 PROS1 CLU SERPINA5 PLAU MIR6843 CR2 CR1 SERPINF2 PLAUR CFD F5 C1QA F8 C1S F9 C1R SERPING1 CD46 F7 CPB2 CFH C2 C4B SERPINC1 CFI C3 TFPI LMAN1 C6 C8G F10 C7 F12 C9 PROC MASP2 F13B MASP1 KLKB1 CFB CD55 C1QC C3AR1 F2R F2 BDKRB1 SERPINA1 KNG1 AMINO ACID METABOLISM PATHWAY EXCERPT (HISTIDINE CATABOLISM EXTENSION)%WIKIPATHWAYS_20200510%WP4661%HOMO SAPIENS Amino Acid Metabolism Pathway Excerpt (Histidine catabolism extension) GPT2 FTCD GLUD1 HAL UROC1 AMDHD1 IL-6 SIGNALING PATHWAY%WIKIPATHWAYS_20200510%WP364%HOMO SAPIENS IL-6 signaling pathway CRP RPS6KB1 IRF1 GSK3B AKT1 NR2F6 TYK2 PRDM1 HDAC1 MAP3K7 PTPN11 PIK3R2 PIK3R1 STAT1 CREBBP RAC1 MAPK1 IL6ST MAP2K1 MAP2K2 GAB1 VAV1 TIMP1 HCK NLK JUNB NCOA1 BAD PRKCD MAP2K4 IL6R GRB2 SOS1 VIP BCL2L1 SHC1 STAT3 JAK2 MAPK3 AGT JAK1 SOCS3 IL6 DEVELOPMENT AND HETEROGENEITY OF THE ILC FAMILY%WIKIPATHWAYS_20200510%WP3893%HOMO SAPIENS Development and heterogeneity of the ILC family EOMES GFI1 ID2 TSLP IL15 IL23A IL12B IL9 IL25 IL13 TOX BCL11B NFIL3 HNF1A GATA3 TBX21 IL4 IL22 AREG IL12A IFNG ZBTB16 IL18 IL5 RORA IL7 IL17A AHR TNF IL6 IL33 IL1B CATALYTIC CYCLE OF MAMMALIAN FLAVIN-CONTAINING MONOOXYGENASES (FMOS)%WIKIPATHWAYS_20200510%WP688%HOMO SAPIENS Catalytic cycle of mammalian Flavin-containing MonoOxygenases (FMOs) FMO1 FMO3 FMO2 FMO4 FMO5 BIOSYNTHESIS AND REGENERATION OF TETRAHYDROBIOPTERIN (BH4) AND CATABOLISM OF PHENYLALANINE, INCLUDING DISEASES%WIKIPATHWAYS_20200510%WP4156%HOMO SAPIENS Biosynthesis and regeneration of tetrahydrobiopterin (BH4) and catabolism of phenylalanine, including diseases GCH1 PTS SLEEP REGULATION%WIKIPATHWAYS_20200510%WP3591%HOMO SAPIENS Sleep regulation TH NPAS2 DRD3 DLAT NLGN1 STAR BTBD9 HTR2A OXT MRGPRX2 SLC29A1 ADORA2A HCRTR2 ADA AHCY OXTR HCRTR1 NPY2R NPS CST3 MTNR1B GRIN2A DRD2 CACNA1I DRD1 PTGDR PER3 IL18 GHRH GHRL CRH FOS PTGDS ADORA1 CHRNB2 UTS2R IL6 UTS2 METASTATIC BRAIN TUMOR%WIKIPATHWAYS_20200510%WP2249%HOMO SAPIENS Metastatic brain tumor E2F3 MIR29B1 CDK6 MYC TP53 PIK3R1 MIRLET7BHG MIR29B2 MIRLET7B MIR148B MIRLET7F2 MIR4763 MIRLET7A2 CDC42 MIR101-1 NOTCH SIGNALING%WIKIPATHWAYS_20200510%WP268%HOMO SAPIENS Notch Signaling NCOR2 ADAM17 NUMB MAML3 NOTCH2 NOTCH3 HDAC2 NUMBL NOTCH1 HDAC1 NOTCH4 PSEN2 DTX1 PSEN1 DLL1 DLL3 DLL4 APH1A NCSTN APH1B HES5 JAG2 CREBBP DTX2 HES1 DTX3 JAG1 RBPJL RFNG DTX4 KAT2B LFNG DTX3L KAT2A MIR6808 MFNG CTBP2 CTBP1 DVL1 DVL2 KCNJ5 DVL3 INPP5K MAML1 RBPJ PTCRA CHOLESTEROL BIOSYNTHESIS PATHWAY%WIKIPATHWAYS_20200510%WP197%HOMO SAPIENS Cholesterol Biosynthesis Pathway MVK MSMO1 LSS HMGCR SQLE NSDHL PMVK SC5D MVD DHCR7 FDFT1 FDPS HMGCS1 CYP51A1 IDI1 HOST-PATHOGEN INTERACTION OF HUMAN CORONA VIRUSES - INTERFERON INDUCTION%WIKIPATHWAYS_20200510%WP4880%HOMO SAPIENS Host-pathogen interaction of human corona viruses - Interferon induction IRF3 TRAF3 MAVS RIPK1 TYK2 TICAM1 TRAF6 MAP3K7 EIF2AK2 STAT1 MAPK8 TBK1 IKBKE IFNAR2 STAT2 OAS1 OAS2 OAS3 TLR7 IRF9 IFNAR1 MYD88 IFIH1 CHUK FOS MAPK14 NFKB1 IKBKB DDX58 JUN NFKBIA JAK1 IKBKG REGULATION OF ACTIN CYTOSKELETON%WIKIPATHWAYS_20200510%WP51%HOMO SAPIENS Regulation of Actin Cytoskeleton DIAPH1 BCAR1 ROCK2 EZR ARPC5 PIP5K1B FGF1 APC2 FGF3 FGF4 FGF5 FGF6 FGF7 FGF9 PXN PIK3CD PDGFRA EGFR CDC42 NRAS MAPK1 PDGFB MAP2K1 MAP2K2 FGF2 ITGA1 FN1 PTK2 APC FGF20 FGF23 FGF22 KRAS FGF21 SOS1 RAF1 FGF17 FGF16 FGF14 FGF18 PIK3C2B PDGFRB FGF13 FGFR3 FGF12 FGFR2 FGF11 FGF10 FGFR1 SLC9A1 ACTN1 ARHGEF1 PIP5K1C PIK3R3 PIK3R2 PIK3R1 GNA12 PIK3CB GNA13 PIK3CA ARHGAP35 MYLK MSN VCL PIK3R5 F2R F2 PPP1R12A MYL1 DOCK1 CHRM2 CHRM3 CHRM1 CHRM4 MAPK3 CHRM5 PAK1 CFL1 PIP4K2A PAK7 PAK6 PFN1 PAK3 PAK2 PAK4 SOS2 PIK3C2G PIK3C2A PIK3CG RAC2 RAC1 CRK EGF BRAF RHOA NCKAP1 TMSB4X PIP4K2B PIP4K2C MYL3 PIP5K1A MYH10 MAPK6 RDX FGF19 PIK3R4 RASSF7 SSH2 FGFR4 MAPK4 SSH3 SSH1 VIL1 DIAPH3 IQGAP1 BRK1 PIP5KL1 GIT1 ENAH ARHGEF4 PIK3C3 ARHGEF7 ARHGEF6 FGD1 WASF1 WASF2 GSN BAIAP2 MOS ABI2 ACTB ACTG1 VAV1 BDKRB2 PDGFA BDKRB1 RRAS WAS CFL2 CD14 GNG12 CYFIP2 CSK RAC3 ROCK1 FGF8 RRAS2 MRAS LIMK1 MAMMARY GLAND DEVELOPMENT PATHWAY - INVOLUTION (STAGE 4 OF 4)%WIKIPATHWAYS_20200510%WP2815%HOMO SAPIENS Mammary gland development pathway - Involution (Stage 4 of 4) MYC BAX IL6ST MMP9 TP53 CHI3L1 STAT3 SOCS3 CDH1 E2F1 HOMOLOGOUS RECOMBINATION%WIKIPATHWAYS_20200510%WP186%HOMO SAPIENS Homologous recombination RAD52 ATM RAD54B NBN MRE11A POLD3 POLD4 RAD50 RAD51 POLD1 POLD2 BRCA2 RPA1 VITAMIN D METABOLISM%WIKIPATHWAYS_20200510%WP1531%HOMO SAPIENS Vitamin D Metabolism VDR CYP27A1 CYP24A1 CYP2R1 DHCR7 GC RXRB CYP27B1 RXRA PTH SELENIUM MICRONUTRIENT NETWORK%WIKIPATHWAYS_20200510%WP15%HOMO SAPIENS Selenium Micronutrient Network CRP SEPN1 PRDX4 ALOX5 PLAT PNPO PLG APOB EPT1 ALOX5AP INSR ALB SAA1 FGB ALOX15B SAA2 FGA TXNRD3 MSRB1 FGG GPX4 PRDX1 MTR PTGS1 XDH GPX1 GPX3 TXNRD2 TXNRD1 GSR DIO2 SOD2 NFKB2 SOD3 SOD1 CBS MIR6886 CAT DIO1 DIO3 LDLR SERPINE1 GGTLC2 GGTLC1 PTGS2 CTH GGT1 GGT2 ABCA1 GGTLC3 HBA1 APOA1 GPX2 F7 ICAM1 TXN CCL2 IFNG F2 INS MTHFR SCARB1 HBB MPO FLAD1 RFK KYNU SEPHS2 TNF GPX6 KMO RELA SEPP1 NFKB1 VIMP SAA3P SAA4 SEPW1 PRDX3 PRDX2 IL6 C11orf31 IL1B PRDX5 PPAR ALPHA PATHWAY%WIKIPATHWAYS_20200510%WP2878%HOMO SAPIENS PPAR Alpha Pathway CDK1 CYP4A11 CPT2 CCND1 CYP8B1 PPARA SLC27A1 DBI SCP2 MYC APOA2 CPT1A APOA1 APOA5 ACADM ACAA1 NR1H3 PLTP APOC3 FABP1 UGT1A9 CDK4 EHHADH KLK15 CYP4A22 CYP7A1 RXRA CELLULAR PROTEOSTASIS%WIKIPATHWAYS_20200510%WP4918%HOMO SAPIENS Cellular Proteostasis VBP1 MIR6834 PFDN1 PFDN2 PFDN4 PFDN5 PFDN6 FOLATE-ALCOHOL AND CANCER PATHWAY HYPOTHESES%WIKIPATHWAYS_20200510%WP1589%HOMO SAPIENS Folate-Alcohol and Cancer Pathway Hypotheses CEBPB MTR ADH5 CREB1 CBS ALDH1A1 ALDH1L1 CYP2E1 MTHFR NANOPARTICLE TRIGGERED REGULATED NECROSIS%WIKIPATHWAYS_20200510%WP2513%HOMO SAPIENS Nanoparticle triggered regulated necrosis FADD TNF CASP8 RIPK3 PLA2G4A PARP1 FTL RIPK1 TICAM1 MAPK8 TNFRSF1A TRADD MIRNAS INVOLVED IN DNA DAMAGE RESPONSE%WIKIPATHWAYS_20200510%WP1545%HOMO SAPIENS miRNAs involved in DNA damage response RAD52 MIR203A CDKN1A MIR449C MIR503 MIR106B MIR3074 MIR93 CCND1 MIR372 MIR181A1 MIR25 ATM MIR371A MIR27A CCND3 MIR23B MIR449B MIR449A MIR100 H2AFX MIR222 MIR145 MYC MIR221 CDC25A TP53 MIR181B1 MIR373 MIR16-1 E2F1 MIR15B MIR23A CDK6 MIR210 CREB1 CDKN1B ABL1 CCNE1 LNCRNA-MEDIATED MECHANISMS OF THERAPEUTIC RESISTANCE%WIKIPATHWAYS_20200510%WP3672%HOMO SAPIENS LncRNA-mediated mechanisms of therapeutic resistance VLDLR-AS1 UCA1 CDKN1A LINC-ROR HIF1A LINC00970 TP53 BCL2L1 ABCB1 WNT6 MEG3 HOTAIR RESISTIN AS A REGULATOR OF INFLAMMATION%WIKIPATHWAYS_20200510%WP4481%HOMO SAPIENS Resistin as a regulator of inflammation PLCB2 IL12B AKT2 AKT1 PLCD4 RETN PLCD3 PIK3CG PLCE1 PIK3CD PIK3CB IL12A PIK3CA CXCL8 AKT3 PLCG2 PLCD1 MAPK1 PLCG1 CHUK PLCB1 ITPR1 MAPK14 TNF RELA NFKB1 IKBKB NFKBIA PLCB3 PLCB4 MAPK3 IL6 IKBKG BONE MORPHOGENIC PROTEIN (BMP) SIGNALLING AND REGULATION%WIKIPATHWAYS_20200510%WP1425%HOMO SAPIENS Bone Morphogenic Protein (BMP) Signalling and Regulation SMAD6 BMP2 NOG BMPR2 SMURF1 TOB2 BMPR1B SMAD4 TOB1 SMAD1 RUNX2 BMPR1A SIGNAL TRANSDUCTION THROUGH IL1R%WIKIPATHWAYS_20200510%WP4496%HOMO SAPIENS Signal transduction through IL1R MAP2K6 TGFB1 TGFB3 IRAK2 MAP3K14 TRAF6 IFNA1 MAP3K7 MAPK8 IFNB1 IL1R1 IRAK1 MIR6502 IRAK3 IL1RAP MIR718 TOLLIP MAP2K3 MAP3K1 MYD88 CHUK TGFB2 ECSIT MAPK14 TNF RELA NFKB1 IKBKB JUN NFKBIA TAB1 IL1RN IL1A IL6 IL1B HEPATITIS B INFECTION%WIKIPATHWAYS_20200510%WP4666%HOMO SAPIENS Hepatitis B infection MAP2K6 DDB1 FAS TYK2 EGR2 STAT6 SRC SMAD2 PIK3CD MAPK9 CREBBP MAPK8 NRAS AKT3 MAPK1 HRAS MAP2K1 MIR1281 MAP2K2 MMP9 MAPK12 MAPK13 MAPK10 MAPK11 KRAS GRB2 TGFB2 SOS1 RAF1 DDX58 TAB2 TAB1 ATP6AP1 FASLG MAVS TGFB3 EGR3 TGFBR1 TGFBR2 BCL2 TRAF6 PIK3R3 PIK3R2 PIK3R1 PIK3CB PIK3CA STAT1 TBK1 IRAK1 IKBKE HSPG2 STAT2 DDX3X STAT4 MIR718 MAP2K4 IFNAR1 MYD88 TLR2 STAT3 MAPK3 JAK1 YWHAQ NFATC2 NFATC4 MAP2K7 CDKN1A YWHAB ARAF CASP9 CASP8 AKT2 TICAM2 CASP3 AKT1 IRAK4 TICAM1 JAK3 IFNA5 TIRAP PRKCG IFNA4 YWHAZ PRKCB IFNA7 TLR3 PRKCA IFNA6 DDB2 IFNA1 IFNA2 IFNA8 SOS2 VDAC3 CXCL8 ELK1 IFNB1 CASP12 BID STAT5A STAT5B BAD ATF2 BRAF IFNA13 IFIH1 ATF6B IFNA14 IFNA16 PTK2B BAX IFNA17 CYCS FOS TLR4 SLC10A1 CASP10 CREB3L3 CREB3L4 CREB3L1 CREB3L2 APAF1 CREB3 IFNA10 IRF3 TGFB1 TRAF3 CREB5 ATF4 IRF7 IFNA21 MYC FADD MAP3K7 BIRC5 MAP2K3 SMAD4 MAP3K1 SMAD3 NFATC3 CHUK PCNA NFATC1 MAPK14 CREB1 TNF RELA NFKB1 IKBKB EP300 JUN JAK2 IL6 IKBKG PATHWAYS OF NUCLEIC ACID METABOLISM AND INNATE IMMUNE SENSING%WIKIPATHWAYS_20200510%WP4705%HOMO SAPIENS Pathways of nucleic acid metabolism and innate immune sensing IFNB1 TREX1 IRF3 MAVS OAS1 RNASEH2C RNASEL RNASEH2B RNASEH2A RNASET2 IFIH1 SAMHD1 ADAR MB21D1 DDX58 TMEM173 CLASSICAL PATHWAY OF STEROIDOGENESIS, INCLUDING DISEASES%WIKIPATHWAYS_20200510%WP4523%HOMO SAPIENS Classical pathway of steroidogenesis, including diseases HSD3B2 HSD11B1 HSD11B2 CYB5A POR SRD5A2 HSD17B3 STAR MIR4651 CYP17A1 CYP19A1 CYP11B1 CYP21A2 H6PD CYP11A1 CYP11B2 METABOLISM OF TETRAHYDROCANNABINOL (THC)%WIKIPATHWAYS_20200510%WP4174%HOMO SAPIENS Metabolism of Tetrahydrocannabinol (THC) CYP3A4 CYP2C9 CILIOPATHIES%WIKIPATHWAYS_20200510%WP4803%HOMO SAPIENS Ciliopathies ANKS6 SPATA7 NEK8 IQCB1 CEP290 CCDC40 ANKS3 CEP164 GLI3 GLI2 SUFU TRAF3IP1 CSPP1 IFT172 TMEM138 LCA5 CEP19 RP2 CEP120 NPHP1 NPHP3 NPHP4 XPNPEP3 DYNC2H1 IFT80 AHI1 RPGRIP1L LZTFL1 KIAA0586 TMEM237 IFT81 UNC119 CEP41 WDPCP B9D2 CEP104 ZNF423 ARL6 ARL3 TTBK2 DYNC2LI1 TTC21B INPP5E INVS TCTEX1D2 PIBF1 BBS2 BBS1 IFT122 TMEM231 ICK TMEM17 WDR60 MKS1 IFT27 CEP83 C2CD3 C5orf42 IFT52 TCTN3 TCTN2 TCTN1 TMEM107 BBS9 GALNT11 BBS7 C21orf2 IFT57 CCDC28B CC2D2A MCIDAS BBS5 TBC1D32 BBS4 NEK1 OFD1 NEK2 MKKS DNAAF3 DNAAF2 IFT140 DNAAF1 DNAJB13 DNAAF5 OCRL WDR34 SMO WDR35 FAM161A TOPORS BBS10 GPR161 EVC MAK IFT43 ARMC4 BBS12 PIH1D3 TMEM216 CCDC151 CCNO AK7 GLIS2 PKHD1 ADCY6 KIAA0556 ARL13B CEP78 RAB23 PLK4 TMEM67 NEK9 KIAA0753 DNAH11 EVC2 DCDC2 WDR19 FAM187A SCLT1 C8orf37 ARL2BP DRC1 DNAL1 TTC25 TTC8 LRRC6 PKD2 PKD1 CRX B9D1 C21orf59 CLUAP1 FLCN ZIC2 HYDIN TAPT1 DDX59 DNAI2 CFAP52 CCDC114 KIF7 POMGNT1 RP1 NME7 NME9 EFHC1 ZMYND10 KIZ CFAP53 GAS8 SDCCAG8 CCDC103 DNAH6 PKD1L1 RSPH9 PIK3R4 TULP1 POC1A POC1B INTU RAB28 DNAI1 TUB RSPH4A DYX1C1 USP9X FAM58A C2orf71 RSPH3 RP1L1 RPGRIP1 BBIP1 PDE6D TTLL5 RSPH1 CENPF MIR6511B1 ALMS1 SPAG1 HYLS1 CCDC65 ATXN10 TRIM32 CNGA1 CNGB1 EBOLA VIRUS PATHWAY ON HOST%WIKIPATHWAYS_20200510%WP4217%HOMO SAPIENS Ebola Virus Pathway on Host RELB FLNA ADAM17 FLNB FLNC REL CLTC CLTB CLTA IL4 ITGB1 PIK3CD EGFR CREBBP CDC42 CTSB MAPK1 MIR1281 CLTCL1 ITGA1 CLEC4M CLEC10A ICAM2 ICAM3 VPS39 KPNA1 VPS18 CD300A VPS4A VPS33A TIMD4 TYRO3 CLEC4G NFKB2 TSG101 VPS11 VPS16 MIR4709 DDX58 BST2 CD209 CLEC6A RAB5A ASGR1 SCIN CTSL C1QBP HAVCR1 MBL2 HAVCR2 NPC2 MFGE8 GAS6 HLA-DQB2 RAB7A EPS15 DAB2IP ACTN1 MERTK ACTN4 TPCN2 PRKRA AXL NEDD4 VPS41 RAB9A RASA2 PIK3R3 PIK3R2 PIK3R1 PIK3CB IGF1R EIF2AK2 PIK3CA STAT1 HLA-DRB1 TBK1 IKBKE CAV3 CAV2 CAV1 ITGA3 MAPK3 PAK1 SOCS3 AKT1 RHOC RHOB FOLR1 HLA-DOA HLA-DOB HLA-DPA1 TOP1 RAC1 HLA-B HLA-C HLA-A HLA-F HLA-G NPC1 HLA-E HLA-DQB1 HLA-DMA HLA-DMB HLA-DQA2 HLA-DQA1 HLA-DRB5 RHOA HLA-DPB1 HLA-DRA TLR4 IQGAP1 IRF3 IRF7 GSN ITGA4 ITGA2 ITGA6 ITGB3 EIF2S1 ITGAV ITGA5 ACTB ACTG1 VAV2 TIAM1 TFAP2A RELA NFKB1 EP300 RFC1 HIF1A AND PPARG REGULATION OF GLYCOLYSIS%WIKIPATHWAYS_20200510%WP2456%HOMO SAPIENS HIF1A and PPARG regulation of glycolysis TPI1 HIF1A SLC2A1 AGPAT9 GAPDH GPD1 PPARG LDHA VIRAL ACUTE MYOCARDITIS%WIKIPATHWAYS_20200510%WP4298%HOMO SAPIENS Viral Acute Myocarditis ILK MYH6 CHRAC1 BNIP2 ABL2 CASP9 DMD JKAMP CASP8 IL12B EIF4G2 CCND1 TLR5 EIF4G1 CASP2 GSK3B CASP3 AKT1 IL10 TICAM1 ENDOG TLR3 AIF1 SRC IL12A RAC2 PYCARD NOD2 MAPK1 MMP9 BID MIR7705 HLA-DMA PARP1 MICA CD40LG SOS1 CD4 CASP7 BAX CASP6 TLR4 CYCS NFKB2 CASP1 BCL2L1 DFFB DFFA TGFB1 IL2 BCL2 PABPC1 FYN NOS1 RASA1 CD80 PIK3R1 CXCR4 STAT1 ACTB EDN1 LAMA2 CD55 CCR3 IFNG CAV1 CCR5 CREB1 TNF RAC3 ITGB2 ITGAL DAG1 ABL1 CAAP1 STAT3 SGCD MAPK3 SGCA JAK1 SGCB IL6 SGCG PTCRA SOCS1 KRT8 INTERFERON TYPE I SIGNALING PATHWAYS%WIKIPATHWAYS_20200510%WP585%HOMO SAPIENS Interferon type I signaling pathways RPS6 EIF4EBP1 MAP2K6 LCK PIAS1 REL TYK2 GAB2 RPTOR MIR4680 PDCD4 PIAS3 PIK3CD RAC1 ZAP70 GNB2L1 MLST8 STAT5A RAPGEF1 CRK CBL PTPRC MAPKAP1 EIF4E MTOR RPS6KB1 FYN IRS1 PTPN11 PIK3R2 IRS2 PIK3R1 RPS6KA4 STAT1 PTPN6 RPS6KA5 IFNAR2 VAV1 STAT2 STAT4 RAP1A MAP2K3 IRF9 IFNAR1 MAP3K1 PRMT1 CRKL MAPK14 CREB1 EIF4B EIF4A1 STAT3 JAK1 SOCS3 SOCS1 TYROBP CAUSAL NETWORK%WIKIPATHWAYS_20200510%WP3945%HOMO SAPIENS TYROBP Causal Network ITGAM HCLS1 PLEK TYROBP RGS1 CD84 NRROS FKBP15 NCF2 GIMAP2 ABCC4 LOXL3 TCIRG1 PPP1R18 PYCARD LYL1 CD37 GAL3ST4 IL13RA1 RNASE6 LGALS9C LGALS9B APBB1IP MAF SLC7A7 STAT5A BIN2 ELF4 SFT2D2 TMEM106A RBM47 IL18 IGSF6 GPX1 KCNE3 CAPG SLC1A5 CD4 SAMSN1 ZFP36L2 ITGAX ADAP2 HLX CYTL1 NCKAP1L SH2B3 LHFPL2 MIR4709 CREB3L2 GAPT TNFRSF1B NPC2 MIR7846 DPYD RUNX3 TGFBR1 CXCL16 C3 SPP1 RPS6KA1 C1QC IL10RA ITGB2 OVERVIEW OF LEUKOCYTE-INTRINSIC HIPPO PATHWAY FUNCTIONS%WIKIPATHWAYS_20200510%WP4542%HOMO SAPIENS Overview of leukocyte-intrinsic Hippo pathway functions LPL VMP1 CD19 TEAD1 TEAD2 RASSF5 TEAD3 TEAD4 MST1 PRDM1 LATS1 FOXO3 RAC1 FOXO6 FYB YAP1 KNSTRN MOB1A FOXP3 RAB13 FERMT3 RAP1A CCR7 RHOA NDRG1 MAPK14 LATS2 STK38L ITGAL TAZ STK3 SAV1 FOXO1 YWHAQ MIR21 FOXO4 SOMATROPH AXIS (GH) AND ITS RELATIONSHIP TO DIETARY RESTRICTION AND AGING%WIKIPATHWAYS_20200510%WP4186%HOMO SAPIENS Somatroph axis (GH) and its relationship to dietary restriction and aging SIRT1 PTEN AKT1 IGF1R FOXO1 MTOR ETHANOL EFFECTS ON HISTONE MODIFICATIONS%WIKIPATHWAYS_20200510%WP3996%HOMO SAPIENS Ethanol effects on histone modifications CYP2E1 HDAC2 HDAC1 ALDH1A2 AHCY TYMS MTR KAT2B MAT1A ALDH1A1 EHMT2 ATF2 HDAC10 ADH1C MTHFR ADH1B ADH1A HDAC4 HDAC6 HDAC3 SLC19A1 ELP3 ALDH2 ALDH1A3 HDAC8 HAT1 HDAC9 DHFR HDAC7 HDAC5 ACSS2 PATHOGENESIS OF SARS-COV-2 MEDIATED BY NSP9/NSP10 COMPLEX%WIKIPATHWAYS_20200510%WP4884%HOMO SAPIENS Pathogenesis of SARS-CoV-2 Mediated by nsp9/nsp10 Complex CRP CD2 HLA-DRB1 ZAP70 MMP25 CD8B IGLL1 CD8A NKRF CD247 LCK LBP HLA-DRB5 CD4 FYN HLA-DRA CXCL8 CD3G IL6 PRG3 CD3E STEROL REGULATORY ELEMENT-BINDING PROTEINS (SREBP) SIGNALLING%WIKIPATHWAYS_20200510%WP1982%HOMO SAPIENS Sterol Regulatory Element-Binding Proteins (SREBP) signalling LPL MIR33B MIR33A CDK8 PRKAG1 AKT1 PPARG PRKAG2 MBTPS1 SEC13 PRKAG3 RBP4 KPNB1 SEC23A SAR1A SAR1B GSK3A PRKAB2 INSIG2 INSIG1 RNF139 SCAP SEC23B NFYA SEC31B MBTPS2 PRKAB1 SEC31A CAMP SEC24B SEC24A AMFR GPAM SEC24D SEC24C PPARGC1B ACLY FGF21 PRKAA1 PRKAA2 SP1 MIR6886 ACACA ACSS1 LDLR MDH1 MTOR IDI1 HMGCR FDFT1 DBI FDPS SREBF1 HMGCS1 NR1H2 PIK3CA CYP51A1 LSS SREBF2 YY1 SQLE SCD FASN MVD PRKACA INS SCARB1 LPIN1 MED15 CREB1 SIRT1 ATF6 INTEGRIN-MEDIATED CELL ADHESION%WIKIPATHWAYS_20200510%WP185%HOMO SAPIENS Integrin-mediated Cell Adhesion MAP2K6 ILK BCAR1 ROCK2 ITGB1 SRC PXN CDC42 AKT3 MAPK1 HRAS MAP2K1 MAP2K2 ITGA1 PTK2 MAPK12 MAPK10 GRB2 MIR6852 SOS1 RAF1 TLN1 ITGAE CAPN9 ITGAX CAPNS1 CAPN6 ITGAD CAPN7 CAPN5 CAPN3 CAPN1 TNS1 MYPN GIT2 CAPN11 CAPN10 VAV3 VASP PIK3R2 ZYX MYLK2 CAPN2 VCL CAV3 CAV2 CAV1 ITGA3 DOCK1 ITGA8 SHC3 ITGB5 ITGB4 SHC1 ITGB2 ITGAL PAK1 ITGAM ITGB8 MAP2K5 PAK6 ARAF ITGB7 ITGB6 PAK3 PAK2 AKT2 PAK4 AKT1 RAC2 RAC1 PDPK1 ITGA2B RAPGEF1 CRK BRAF MAPK7 MAPK6 MAPK4 SORBS1 ARHGEF7 ITGA10 ITGA11 FYN ITGA4 ITGA2 ITGA7 ITGA6 ITGB3 ITGAV ITGA5 ITGA9 RAP1B VAV2 RAP1A MAP2K3 CSK RAC3 ROCK1 SEPP1 RHO GLYCEROLIPIDS AND GLYCEROPHOSPHOLIPIDS%WIKIPATHWAYS_20200510%WP4722%HOMO SAPIENS Glycerolipids and Glycerophospholipids PCYT1A PCYT2 PISD PTDSS2 PTDSS1 ETNK1 MIR7109 CHKB PEMT CDS1 CHPT1 AGPAT6 DGAT2 DGAT1 PLA2G1B PNPLA2 PLD1 CRLS1 DGKZ AGPAT4 MIR6848 PNPLA3 CDIPT GPAM PROTEASOME DEGRADATION%WIKIPATHWAYS_20200510%WP183%HOMO SAPIENS Proteasome Degradation PSMD12 PSMD13 UBB UBC PSMC3 PSMC1 PSMC2 H2AFX UBA1 HLA-B UBE2D3 HLA-C HLA-A HLA-F HLA-G HLA-E PSMD8 PSMD7 PSMC5 NEDD4 PSMB9 H2AFZ MIR5193 UBE2D1 UCHL1 PSMD9 HIST1H2AB UCHL3 PSMD6 PSMA5 IFNG PSMA6 PSMA3 PSMD4 PSMA4 PSMD5 PSMA1 PSMA2 PSME3 PSMD2 PSME1 PSME2 PSMD3 UBA7 PSMD1 RPN2 PSMC6 RPN1 PSMC4 PSMB10 PSMA7 PSMB6 PSMB7 UBE2D2 PSMB4 PSMD10 PSMB5 PSMD11 PSMB2 PSMB3 PSMB1 UBE2B PSMB8 MIR7703 GLYCOSYLATION AND RELATED CONGENITAL DEFECTS%WIKIPATHWAYS_20200510%WP4521%HOMO SAPIENS Glycosylation and related congenital defects DPAGT1 B4GALT1 TUSC3 MPI MAGT1 GMPPB MGAT2 MPDU1 ALG8 ALG9 ALG6 SRD5A3 ALG14 ALG2 ALG3 ALG13 MOGS DOLK ALG12 ALG11 DPM1 DPM2 DPM3 PMM2 ALG1 PARKINSONS DISEASE PATHWAY%WIKIPATHWAYS_20200510%WP2371%HOMO SAPIENS Parkinsons Disease Pathway SNCA CASP9 HTRA2 UBB UBE2G1 UBE2G2 CASP2 SEPT5 SNCAIP CASP3 PARK7 UBA1 EPRS MIR16-2 MAPK12 MAPK13 MAPK11 CASP7 CASP6 CYCS CCNE2 DDC APAF1 CCNE1 LRRK2 TH MIR503 MIR30A MIR6084 MIR10A MIR106A MIR431 MIR26A1 MIR195 MIR26A2 MIR497HG MIR1224 MIR128-2 MIR20B MIR92A2 ATXN2 MIR212 MIR497 MIR132 MIR20A MIR4448 MIR17 MIR1294 MIR19B2 PINK1 SYT11 UBE2L6 PARK2 MIR19B1 MIR5193 UBE2L3 UCHL1 MIR19A MIR92A1 MIR17HG SLC6A3 UBA7 GPR37 MAPK14 UBE2J2 UBE2J1 ASSOCIATION BETWEEN PHYSICO-CHEMICAL FEATURES AND TOXICITY ASSOCIATED PATHWAYS%WIKIPATHWAYS_20200510%WP3680%HOMO SAPIENS Association Between Physico-Chemical Features and Toxicity Associated Pathways FZD6 FZD9 CDKN1A ROCK2 FZD8 PFN1 GSK3B AKT1 ACTA1 AXIN1 WNT16 PIK3CG SRC TGFA EGFR MAPK8 WNT11 ERBB2 ELK1 MAPK1 MAP2K1 PLCG1 FN1 MIR6808 STAT5A PTK2 APC CTNNB1 GPX1 RHOA GRB2 SOS1 TMSB4X RAF1 CBL ERBB4 DAAM1 SOD1 CDKN1B CAMK1 FZD10 NEFL NEFM MYC NOS1 FZD4 GRIA1 PPP2CA MYLK NEFH ACTR3 ACTR2 NCK1 PFN4 PFN3 PFN2 MAP2K4 MYL1 DVL1 MIR4683 SHC1 FZD1 JUN FZD3 PAK1 FZD2 FZD5 FZD7 SIMPLIFIED DEPICTION OF MYD88 DISTINCT INPUT-OUTPUT PATHWAY%WIKIPATHWAYS_20200510%WP3877%HOMO SAPIENS Simplified Depiction of MYD88 Distinct Input-Output Pathway IRAK1 TLR5 MIR718 TLR7 TLR1 TIFA TLR9 UBE2N MYD88 TLR10 TLR2 TLR6 UBE2V1 TRAF6 TLR4 NFKB1 JUN TLR8 IL1A MIRNAS INVOLVEMENT IN THE IMMUNE RESPONSE IN SEPSIS%WIKIPATHWAYS_20200510%WP4329%HOMO SAPIENS miRNAs involvement in the immune response in sepsis RELB REL IL10 IRAK4 ELANE MIR29B1 MIR16-2 LCN2 TLR8 CXCL8 MIR16-1 MAPK8 MIR126 TLR4 NFKB2 TAB2 TAB1 MIR203A TRAF3 IRF1 MIR125B1 MIR125B2 MIR106B IRF7 IRF5 MIR199A2 MIR145 TRAF6 MAP3K7 MIR199A1 ICAM1 IRAK1 MIR718 TLR7 GZMB MYD88 CHUK CCL4 CCL3 MAPK14 TNF RELA VCAM1 MIR149 NFKB1 IKBKB MIR155 MIR4461 NFKBIA MIR758 MIR155HG MIR223 IL1A IL6 MIR187 IKBKG CARDIAC HYPERTROPHIC RESPONSE%WIKIPATHWAYS_20200510%WP2795%HOMO SAPIENS Cardiac Hypertrophic Response MAP2K6 MAP2K7 CDK9 MIR3960 MAP2K5 AKT2 GSK3B AKT1 MAP3K14 PRKCA CAMK2D CDK7 MAPK8 PLA2G2A RAC1 NPPA MAP4K1 MAPK1 MAP2K1 PDPK1 MAP2K2 FGF2 PRKG1 NRG1 EGF RAF1 MAPK7 HDAC5 MTOR FGFR2 TGFB1 PRKD1 MEF2A TGFBR1 TNFRSF1A MAP3K7 IKBKE IGF1 MAP2K3 MAP2K4 MAP3K1 CHUK HDAC4 MAPK14 TNF HDAC9 HDAC7 NFKB1 IKBKB CALM3 CALM1 PPP3CA CALM2 MAPK3 GUCA1A NFATC2 IKBKG TYROSINE METABOLISM%WIKIPATHWAYS_20200510%WP4506%HOMO SAPIENS Tyrosine Metabolism HGD HPD FAH TAT GLYCEROPHOSPHOLIPID BIOSYNTHETIC PATHWAY%WIKIPATHWAYS_20200510%WP2533%HOMO SAPIENS Glycerophospholipid Biosynthetic Pathway PCYT2 MOGAT3 PGS1 PTDSS1 PTPMT1 GPAT2 IPMK GNPAT CHKB AGPS PEMT CHPT1 LPIN2 AGPAT6 CEPT1 PI4K2A CDS2 CRLS1 CDIPT PIK3CG PIK3CD PIK3CB PIK3CA GPAM GK PLA2G2A LPIN1 PIP5K1A AGPAT9 GPD1 REGULATION OF TOLL-LIKE RECEPTOR SIGNALING PATHWAY%WIKIPATHWAYS_20200510%WP1449%HOMO SAPIENS Regulation of toll-like receptor signaling pathway MAP2K6 TLR5 TNFAIP3 TREM1 USP7 FBXW5 CD180 TRAFD1 RNF41 PIK3CD SIGIRR BTK TLR8 RBCK1 MAPK9 RNF216 MAPK8 CUEDC2 AKT3 MIR98 TMED7 MAPK1 SFTPD MAP2K1 MIR105-1 MAP2K2 PELI1 ZMYND11 MLST8 RNF31 SFTPA2 PELI3 MAPK12 PELI2 MAPK13 TOLLIP CTNNAL1 TAB3 MAPK10 SARM1 MAPK11 NFKB2 SQSTM1 TAB2 TAB1 PLK1 MBL2 CYLD TRAF6 SMAD6 CD86 CD80 PIK3R3 PIK3R2 PIK3R1 PIK3CB PIK3CA STAT1 PTPN6 TBK1 IRAK1 MIR6502 IKBKE IRAK3 IFNAR2 PIK3R5 MAP3K8 MIR718 TLR7 TLR1 MAP2K4 IFNAR1 MYD88 TLR2 MAPK3 SOCS1 LY96 MAP2K7 CXCL10 IRAK2 IL12B CASP8 LBP AKT2 TICAM2 AKT1 RIPK1 IRAK4 TICAM1 IFNA5 TIRAP IFNA4 IFNA7 TLR3 IFNA6 IFNA1 IFNA2 IFNA8 PIK3CG SYK CD40 IL12A CXCL8 RAC1 IFNB1 IFNA13 IFNA14 IFNA16 IFNA17 FOS TLR4 IFNA10 IRF3 TRAF3 IRF7 IFNA21 IRF5 FADD MAP3K7 CXCL11 SPP1 CXCL9 MAP2K3 TIFA TLR9 CD14 CHUK TLR6 CCL5 OTUD5 CCL4 CCL3 MAPK14 TNF RELA NFKB1 IKBKB JUN NFKBIA IL6 CISH IKBKG IL1B HEDGEHOG SIGNALING PATHWAY NETPATH%WIKIPATHWAYS_20200510%WP47%HOMO SAPIENS Hedgehog Signaling Pathway Netpath DHH PTCH2 IHH ARNTL STK36 SAP18 SMO GLI1 KIF7 ADRBK1 PTCH1 SHH SIN3A GLI3 GLI2 SUFU BRAIN-DERIVED NEUROTROPHIC FACTOR (BDNF) SIGNALING PATHWAY%WIKIPATHWAYS_20200510%WP2380%HOMO SAPIENS Brain-Derived Neurotrophic Factor (BDNF) signaling pathway RPS6 ACACB NTF3 ADAM17 SH2B1 GSK3B MAPT EGR2 CYFIP1 ALPL SRC MAPK9 CDC42 MAPK8 GRIN2B MAPK1 HRAS MAP2K1 EEF2 DLG1 MAP2K2 GNB2L1 CNR1 APC CTNNB1 MAPK10 KSR1 GRB2 RAF1 BDNF SQSTM1 VAV3 KIDINS220 CDK5 SORT1 RAB3A SIRPA NSF FRS3 NGF DOK5 KCNN2 GABRB3 DOCK3 RHOG SYN1 TRAF6 KCNA3 IGF2BP1 IRS1 LINGO1 MARCKS CDK5R1 PTPN11 PIK3R2 IRS2 PIK3R1 PPP2CA STAT1 RPS6KA3 NCK2 RPS6KA5 NTRK1 NTRK2 NCK1 RPS6KA1 BMP2 TSC2 SHC2 SHC3 SHC1 STAT3 MAPK3 CFL1 NGFR EIF4EBP1 NFATC4 MAP2K5 EGR1 YBX1 CASP3 AKT1 CDH2 PTPRF NCF2 FOXO3 RAC1 ELK1 FRS2 PDPK1 PLCG1 NTRK3 STAT5A STAT5B CDKL5 PRKCD BAD PRKAA1 PTK2B FOS MAPK7 PRKAA2 EIF4E SH2B2 MAP3K2 MTOR CAMK1 RPS6KB1 RASGRF1 MEF2A NCF1 FYN NCAM1 CSNK2A1 MEF2C SHC4 GRIA1 GRIA2 CAMK2A SPP1 EIF2S2 EIF2S1 VAV2 RAP1A BCL2L11 DPYSL2 MAP3K1 RANBP9 GRIA3 CHUK TIAM1 GRIN1 MAPK14 CREB1 RELA CAMK4 CRTC1 NFKB1 GRIP1 IKBKB JUN NFKBIA JAK2 IKBKG COMPOSITION OF LIPID PARTICLES%WIKIPATHWAYS_20200510%WP3601%HOMO SAPIENS Composition of Lipid Particles APOC3 LPL APOA2 APOB APOA1 CETP LCAT MIR6886 APOE LDLR EPITHELIAL TO MESENCHYMAL TRANSITION IN COLORECTAL CANCER%WIKIPATHWAYS_20200510%WP4239%HOMO SAPIENS Epithelial to mesenchymal transition in colorectal cancer MAP2K6 FZD6 FZD9 FZD8 EZH2 GSK3B NOTCH2 OCLN WNT2B NOTCH3 CLDN5 NOTCH1 NOTCH4 WNT16 FOXC2 DLL1 LRP5 DLL3 SMAD2 DLL4 PIK3CD LRP6 JAG2 MAPK8 WNT11 AKT3 JAG1 MAPK1 HRAS TJP1 MAP2K1 MAP2K2 MMP9 WNT7B WNT7A FN1 MAPK12 CTNNB1 MAPK13 MAPK11 KRAS GRB2 RBBP4 ZEB1 TGFB2 SOS1 RAF1 CTDSP1 CLDN4 TWIST1 CLDN1 TGFB3 ZEB2 TGFBR1 TGFBR2 TRAF6 WNT8A PIK3R3 FZD4 WNT9B PIK3R2 PIK3R1 PROX1 PIK3CB PIK3CA SNAI1 CDKL2 MAP2K4 CLDN6 CLDN3 CLDN9 CLDN8 CLDN7 PKP2 COL4A1 PKP1 EIF5A2 TWIST2 NRP2 SHC1 CLDN22 CLDN20 CLDN24 CLDN23 DSP MAPK3 WNT9A PAK1 CLDN11 CDH1 CLDN10 CLDN15 CLDN14 MMP15 CLDN12 CLDN19 CLDN18 STRAP FOXM1 CLDN17 CLDN16 AKT2 TMPRSS4 WNT8B GDF15 AKT1 NUBPL MPP5 DLK1 FMNL2 CRB3 SOS2 TP53 CDH2 SNAI2 TUSC3 PKD1 COL4A2 COL4A4 COL4A3 COL4A6 COL4A5 TGFB1 ID2 JUP ID1 MEF2D VTN MIR6511B1 FZD10 SUZ12 WNT5B EED WNT5A MIR6755 SPARC HIF1A ITGA5 CLDN2 NR2C2 MMP2 MAP2K3 WNT6 SMAD4 SMAD3 FOXQ1 WNT1 WNT2 MIR4683 MAPK14 WNT3 LATS2 WNT4 RBPJ FZD1 WNT10B FZD3 WNT10A FZD2 FZD5 WNT3A FZD7 MATRIX METALLOPROTEINASES%WIKIPATHWAYS_20200510%WP129%HOMO SAPIENS Matrix Metalloproteinases MMP23B MMP25 MMP15 MMP17 MMP19 MMP8 MMP7 MMP12 MMP1 MMP3 MMP13 MMP9 MMP2 TIMP2 TIMP1 TIMP3 MMP14 TCF20 TNF MMP21 MMP20 MMP24 MMP27 MMP26 BSG MMP28 TIMP4 MMP10 MMP11 MMP16 EICOSANOID METABOLISM VIA CYTOCHROME P450 MONO-OXYGENASES (CYP) PATHWAY%WIKIPATHWAYS_20200510%WP4720%HOMO SAPIENS Eicosanoid metabolism via Cytochrome P450 Mono-Oxygenases (CYP) pathway CYP2C18 CYP2C8 CYP4A11 CYP4F2 CYP4F12 CYP4A22 PPARG EPHX2 PPARA AMINO ACID CONJUGATION OF BENZOIC ACID%WIKIPATHWAYS_20200510%WP521%HOMO SAPIENS Amino acid conjugation of benzoic acid GLYATL2 GLYATL1 GLYAT ACSS2 MICROGLIA PATHOGEN PHAGOCYTOSIS PATHWAY%WIKIPATHWAYS_20200510%WP3937%HOMO SAPIENS Microglia Pathogen Phagocytosis Pathway ITGAM ARPC1B VAV3 PIK3R6 PIK3C3 TREM1 TYROBP NCF1 C1QB C1QA PIK3R3 PIK3C2A NCF4 PIK3R2 PIK3CG SYK TREM2 PIK3R1 NCF2 PIK3CD PIK3CB FCGR1A LYN FCER1G RAC2 CYBA PIK3CA SIGLEC7 RAC1 PTPN6 PLCG2 VAV1 VAV2 C1QC HCK CYBB LAT RAC3 NCKAP1L ITGB2 THYMIC STROMAL LYMPHOPOIETIN (TSLP) SIGNALING PATHWAY%WIKIPATHWAYS_20200510%WP2203%HOMO SAPIENS Thymic Stromal LymphoPoietin (TSLP) Signaling Pathway EIF4EBP1 RPS6 RELB TNFSF4 TSLP LCK YES1 AKT1 PI4K2A GAB2 MYC FYN STAT6 PTPN11 FES SRC LYN PIK3CA BTK CXCL8 MAPK9 STAT1 MAPK8 MAPK1 MAP2K1 MAP2K2 TEC CRLF2 STAT4 STAT5A STAT5B HCK CCL11 MAPK14 NFKB2 IL2RA IL7R RELA NFKB1 NFKBIA STAT3 JAK2 MAPK3 JAK1 MTOR IL6 CISH OVERVIEW OF NANOPARTICLE EFFECTS%WIKIPATHWAYS_20200510%WP3287%HOMO SAPIENS Overview of nanoparticle effects CRP AKT3 PTGS1 FN1 PTK2 NFRKB LAMA3 HMOX1 PTGS2 CCND3 BCL2 CDH3 BAX COL4A1 TNF ITGAD PIK3CD CXCL8 IL6 GABA RECEPTOR SIGNALING%WIKIPATHWAYS_20200510%WP4159%HOMO SAPIENS GABA receptor Signaling GABRB2 GABRB3 AP2A1 SLC6A1 GPHN SLC6A11 GABBR1 AP2S1 AP2B1 GABRD GABBR2 GABRA1 GABRB1 AP2A2 GABRE GAD1 GABRA2 GABRQ GABRA3 GABRP SLC32A1 GABRA6 GABRA5 GABRA4 GAD2 GABRG3 GABRG1 ABAT MIR224 AP2M1 ALDH9A1 GABRG2 BENZENE METABOLISM%WIKIPATHWAYS_20200510%WP3891%HOMO SAPIENS Benzene metabolism MPO EPHX1 DHDH CYP2E1 NQO1 GSTM1 NCRNAS INVOLVED IN STAT3 SIGNALING IN HEPATOCELLULAR CARCINOMA%WIKIPATHWAYS_20200510%WP4337%HOMO SAPIENS ncRNAs involved in STAT3 signaling in hepatocellular carcinoma IL6ST IL11 IL11RA SOX4 JAK3 IL6R ZEB1 UCA1 RELA NFKB1 STAT3 JAK2 JAK1 IL6 TRIACYLGLYCERIDE SYNTHESIS%WIKIPATHWAYS_20200510%WP325%HOMO SAPIENS Triacylglyceride Synthesis LPL GK2 LIPF MOGAT3 LIPC GNPAT AGPS AGPAT5 DGAT2 MOGAT2 DGAT1 MOGAT1 PNPLA2 PPAP2C AGPAT1 AGPAT3 AGPAT4 MIR6721 MIR6848 PPAP2A LIPE GPAM GK PPAP2B AGPAT2 GPD1 MAMMALIAN DISORDER OF SEXUAL DEVELOPMENT%WIKIPATHWAYS_20200510%WP4842%HOMO SAPIENS Mammalian disorder of sexual development DHH FST FGF9 AMHR2 MIR4321 GATA4 SOX8 RSPO1 SRY AMH INSL3 RBFOX2 DMRT1 SOX9 EMX2 SRD5A1 PBX1 CBX2 FOXL2 NR5A1 CTNNB1 MAPK11 WT1 PTGDS WNT4 FGFR2 ECTODERM DIFFERENTIATION%WIKIPATHWAYS_20200510%WP2858%HOMO SAPIENS Ectoderm Differentiation TNFRSF11B FZD8 SNCA SOCS2 PAX3 TCF3 TFAP2C NLGN1 PRKAG2 FHL2 GATA6 AES ZFHX4 TCF7L1 LHX1 PGM1 CTNNB1 PODXL BMPR1A SCHIP1 CTNND2 CELSR2 TSKU NARS2 GLI3 PIM1 KRT6A ANKS1B KCNK10 IQCJ-SCHIP1 MIR1469 PI4KA HIST1H2BH MZF1 FGFR2 ASTN1 LY6E ARX FOXA2 STC1 ARHGAP15 GLB1 ZBTB2 TRPM2 SDCBP HESX1 AHI1 SPRY2 ST8SIA4 RHPN1 GAS2L1 ZBTB7B GREB1 TOX3 NR2F2 PAN2 SKIL PLCXD3 PTPRB PPFIBP2 MAFB CCDC88C CCDC130 NUMA1 HMGB2 ELOVL4 FZD4 BMP4 LDB2 EDA2R PHF8 SMURF1 WDR44 SIX6 ELOVL2 BOC UBTF RAB8B BCAS3 TSC22D1 SORCS1 PAX6 FOXL1 BAZ1A SERPINB6 ARHGAP10 CCL2 ARHGEF9 KIFC3 MKS1 GRAMD1B STX16 RRBP1 JAKMIP1 CAP2 CLVS1 TTC14 C1GALT1 PTPN13 KIAA1161 EDA VAX2 RIT1 SGSM3 ZNF219 TRIM33 ARHGDIG PLXNA2 CLDN11 DMD RGMA PPARD NF2 OGT CTNNA2 CDH6 ABCC4 MIR15B MECP2 TBL1X JUP MYC FYN PDE7A CDON BCOR POU2F2 ROR2 CTBP1 NLK SMAD4 ZBTB16 HDAC10 CDH8 HDAC6 WNT1 NFATC1 MIR4683 SHH TFAP2A SOX2 FZD5 TRANSLATION INHIBITORS IN CHRONICALLY ACTIVATED PDGFRA CELLS%WIKIPATHWAYS_20200510%WP4566%HOMO SAPIENS Translation inhibitors in chronically activated PDGFRA cells EIF4EBP1 MAP2K6 RPS6 MAP2K7 MAP2K5 RPS6KB1 RPS6KB2 AKT2 EIF4G1 AKT1 EIF4A2 PDK1 RPTOR PRKCA MIR4680 PDCD4 PIK3R3 CSNK2A1 PIK3R2 PIK3CG PIK3R1 PIK3CB RPS6KA4 PIK3CA MAPK9 MAPK8 RPS6KA5 AKT3 MAPK1 RPS6KA2 MAP2K1 RPS6KA1 MAP2K2 MIR1248 MAP2K3 PRKCD MAPK10 PRKACA MAP2K4 EIF4G3 MAPK14 EIF4B EIF4A1 PIM1 EIF4E PIM2 MAPK3 MTOR KISSPEPTIN/KISSPEPTIN RECEPTOR SYSTEM IN THE OVARY%WIKIPATHWAYS_20200510%WP4871%HOMO SAPIENS Kisspeptin/Kisspeptin Receptor System in the Ovary PLCB2 PRKCE HSD3B1 FSHR AKT2 AKT1 STAR PDK1 PRKCG PRKCB PRKCA PIK3CG PIK3CD PIK3CB MIR4321 PIK3CA ARRB1 ARRB2 NRAS AMH MAPK1 HRAS MAP2K1 MAP2K2 MMP9 PRKCD PRKCH KRAS PLCB1 RAF1 PRKCQ NFKB1 PLCB3 PLCB4 MAPK3 BMP15 CYP11A1 KISS1R KISS1 GDF9 LIVER X RECEPTOR PATHWAY%WIKIPATHWAYS_20200510%WP2874%HOMO SAPIENS Liver X Receptor Pathway ABCG5 CYP3A4 SREBF1 ABCG8 SCD FASN NR1H3 CYP7A1 RXRA CYP2B6 MAMMARY GLAND DEVELOPMENT PATHWAY - EMBRYONIC DEVELOPMENT (STAGE 1 OF 4)%WIKIPATHWAYS_20200510%WP2813%HOMO SAPIENS Mammary gland development pathway - Embryonic development (Stage 1 of 4) TGFB1 SFRP1 MIR429 NRG3 CCND1 ZEB2 AKT1 TERT MYC ERBB4 TNF ITGB1 ALPL CLDN4 CDH1 ITGA6 TOLL-LIKE RECEPTOR SIGNALING PATHWAY%WIKIPATHWAYS_20200510%WP75%HOMO SAPIENS Toll-like Receptor Signaling Pathway MAP2K6 TLR5 PIK3CD TLR8 MAPK9 MAPK8 AKT3 MAPK1 MAP2K1 MAP2K2 MAPK12 MAPK13 TOLLIP TAB3 MAPK10 MAPK11 TAB2 TAB1 TRAF6 CD86 CD80 PIK3R3 PIK3R2 PIK3R1 PIK3CB PIK3CA STAT1 TBK1 IRAK1 IKBKE IFNAR2 PIK3R5 MAP3K8 MIR718 TLR7 TLR1 MAP2K4 IFNAR1 MYD88 TLR2 MAPK3 LY96 MAP2K7 CXCL10 IL12B CASP8 LBP AKT2 TICAM2 AKT1 RIPK1 IRAK4 TICAM1 IFNA5 TIRAP IFNA4 IFNA7 TLR3 IFNA6 IFNA1 IFNA2 IFNA8 PIK3CG CD40 IL12A CXCL8 RAC1 IFNB1 IFNA13 IFNA14 IFNA16 IFNA17 FOS TLR4 IFNA10 IRF3 TRAF3 IRF7 IFNA21 IRF5 FADD MAP3K7 NFKBIB CXCL11 SPP1 CXCL9 MAP2K3 TLR9 CD14 CHUK TLR6 CCL5 CCL4 CCL3 MAPK14 TNF RELA NFKB1 IKBKB JUN NFKBIA IL6 IKBKG IL1B SIMPLIFIED INTERACTION MAP BETWEEN LOXL4 AND OXIDATIVE STRESS PATHWAY%WIKIPATHWAYS_20200510%WP3670%HOMO SAPIENS Simplified Interaction Map Between LOXL4 and Oxidative Stress Pathway TGFB1 BMP2 FN1 DDR1 LOXL4 MIR6511B1 MIR4640 SUV39H1 IGFBP7 NRF1 NQO1 ANXA5 COL2A1 ECSIT FGF7 SIRT1 MIR1181 CDC37 EXOC6 NFE2L2 PKD1 AFLATOXIN B1 METABOLISM%WIKIPATHWAYS_20200510%WP699%HOMO SAPIENS Aflatoxin B1 metabolism CYP3A4 CYP2A13 EPHX1 CYP1A2 GSTM1 AKR7A2 AKR7A3 GPCRS, OTHER%WIKIPATHWAYS_20200510%WP117%HOMO SAPIENS GPCRs, Other ADGRD1 GPR143 HTR1F OR2A20P CCKBR LGR6 FSHR OR2A5 OR2A4 SMO MIR4793 GPR18 OR7E24 LTB4R2 ADRA1D ADRB2 HTR2A CXCR1 CXCR3 CXCR2 NTSR1 ADORA2A PTGFR ADORA3 GRM8 ACKR1 ALG6 CNR1 S1PR1 HTR7 CELSR2 UTS2R DRD3 GPR183 OR1G1 OR2M4 GPR61 GPR62 CELSR1 RXFP1 ADGRE2 CELSR3 GHRHR RXFP3 GPR132 GPR176 ADGRE3 GPR135 OR7A17 ADGRL2 ADGRV1 ADGRL3 OR1F1 GRM1 EDNRA OR2H1 TAAR5 GRPR TAAR2 TAAR3 OR1N1 PROKR2 GPR162 OR5AC2 F2R ADGRF5 VN1R1 GNRHR OR10A2 OR6C3 OR3A3 OR6C2 OR3A1 CCR5 OR10A5 DRD4 OR8G1 OR2A9P OR1E1 C5AR2 GPR88 GPR83 GPR84 MCHR2 CHRM2 ADGRG1 CHRM3 HRH4 OR2B6 GPR17 P2RY13 SSTR2 P2RY11 OR2F1 GPR55 COLCHICINE METABOLIC PATHWAY%WIKIPATHWAYS_20200510%WP2536%HOMO SAPIENS Colchicine Metabolic Pathway CYP3A4 CALORIC RESTRICTION AND AGING%WIKIPATHWAYS_20200510%WP4191%HOMO SAPIENS Caloric restriction and aging NAMPT PRKAB2 IGF1 SIRT1 TP53 PPARGC1A AKT1 MTOR SOMITOGENESIS IN THE CONTEXT OF SPONDYLOCOSTAL DYSOSTOSIS%WIKIPATHWAYS_20200510%WP4785%HOMO SAPIENS Somitogenesis in the context of spondylocostal dysostosis TBX6 LFNG DLL1 DLL3 EPHA4 HES7 MESP2 RIPPLY2 NOTCH1 NEURAL CREST DIFFERENTIATION%WIKIPATHWAYS_20200510%WP2064%HOMO SAPIENS Neural Crest Differentiation PAX3 TFAP2B GSK3B NOTCH2 NOTCH3 HDAC2 NOTCH1 HDAC1 NOTCH4 AXIN1 AXIN2 LHX2 ITGB1 DLL1 DLL3 DLL4 SMAD1 HES5 BMP7 TCF7L1 GBX2 FGF2 MIR6808 LHX1 CTNNB1 COL11A2 ZIC1 NFKB2 SOX5 FGFR3 TWIST1 FGFR2 FGFR1 TBX6 HDAC11 MPZ MIA SOX10 ISL1 HOXB1 LHX5 DMBX1 FOXD3 OLIG3 OLIG1 OLIG2 DCT HAND1 WNT8A PRTG PMP22 NEUROG1 BMP4 ZIC5 SOX9 SNAI1 MSX1 HDAC4 HDAC3 HDAC8 HDAC9 HDAC7 PHOX2B MBP CDH1 GFAP PAX7 RHOB COL2A1 ASCL1 CDH6 CDH2 SNAI2 MITF MYB FGF19 ETS1 HDAC5 ID1 MYC TLX2 TCF4 HES1 DLX5 CTBP2 HDAC10 DVL1 CDH7 DVL2 DVL3 HDAC6 WNT1 GJB1 RBPJ MSX2 TFAP2A NFKB1 HEY2 FGF8 FZD3 HOXA1 WNT3A HEROIN METABOLISM%WIKIPATHWAYS_20200510%WP2645%HOMO SAPIENS Heroin metabolism CES2 CES1 BCHE FACTORS AND PATHWAYS AFFECTING INSULIN-LIKE GROWTH FACTOR (IGF1)-AKT SIGNALING%WIKIPATHWAYS_20200510%WP3850%HOMO SAPIENS Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling ILK RPS6KB1 JKAMP GSK3B AKT1 PDK1 TNFRSF1A PLD1 IRS1 ITGB1 PIK3CG SMAD2 PRKAB1 PTEN IGF1R WASL IGF1 TRIM63 NEB FBXO32 PPARGC1A ACVR2B TNFSF9 EIF2B2 SMAD3 IGFBP5 MSTN EIF4E NFKB1 MTOR MAP1LC3A ESTROGEN SIGNALING PATHWAY%WIKIPATHWAYS_20200510%WP712%HOMO SAPIENS Estrogen signaling pathway ELK1 MAPK1 MAP2K1 GNB1 ESR1 AKT1 PRKACA BRAF BCL2 CHUK GPER1 FOS MAPK14 CREB1 GNGT1 NFKB1 SP1 GNAS IKBKB JUN PIK3CA MAPK9 IKBKG TLR4 SIGNALING AND TOLERANCE%WIKIPATHWAYS_20200510%WP3851%HOMO SAPIENS TLR4 Signaling and Tolerance IRF3 TRAF3 IRF7 RIPK1 IRAK4 TICAM1 TIRAP TRAF6 INPP5D MAP3K7 CXCL8 IFNB1 TBK1 IRAK1 MIR6502 IKBKE IRAK3 MIR718 MYD88 CHUK TRAM1 TLR4 TNF NFKB1 IKBKB NFKBIA TAB2 TAB1 IL6 IKBKG TNF ALPHA SIGNALING PATHWAY%WIKIPATHWAYS_20200510%WP231%HOMO SAPIENS TNF alpha Signaling Pathway MAP2K6 MAP2K7 CASP9 CASP8 REL CASP3 AKT1 RIPK1 TNFAIP3 MAP3K14 CUL1 GLUL PYGL MAPK9 MAPK8 CREBBP RAC1 NRAS MAPK1 HRAS MAP4K2 BID SMPD2 MAP3K5 HSP90AA1 TANK BAD TAB3 KSR1 KRAS GRB2 TRADD SOS1 RAF1 CASP7 BAX NFKB2 BTRC BCL2L1 RIPK3 TAB2 TAB1 APAF1 PLK1 MAP3K3 NOX1 TRAF1 TNFRSF1B MIR7846 BIRC2 TRAF2 BIRC3 DIABLO TNFRSF1A FADD MAP3K7 NFKBIE CSNK2A1 NFKBIB PPP2CA CYBA TXN TBK1 CCL2 MAP3K8 MAP2K3 MAP2K4 MAP3K1 PSMD2 CFLAR CHUK RFK OTUD7B TNF KSR2 MADD NFKB1 IKBKB FBXW11 PTPRCAP NSMAF JUN NFKBIA MIR1181 NOXO1 PRKCZ RFFL MAPK3 SKP1 CDC37 TRAP1 SELE IL6 IKBKG CYTOKINES AND INFLAMMATORY RESPONSE%WIKIPATHWAYS_20200510%WP530%HOMO SAPIENS Cytokines and Inflammatory Response TGFB1 IL15 CXCL1 CXCL2 IL12B IL2 IL11 IL10 IL3 IL13 IL4 IFNB1 HLA-DRB1 CSF3 IFNG PDGFA CSF2 CSF1 CD4 IL5 IL7 HLA-DRA TNF IL1A IL6 IL1B MET IN TYPE 1 PAPILLARY RENAL CELL CARCINOMA%WIKIPATHWAYS_20200510%WP4205%HOMO SAPIENS MET in type 1 papillary renal cell carcinoma PRCC PAK7 ALK CDKN1A PAK6 ARAF PAK3 PAK2 RPL11 AKT2 TCEB3 PAK4 C8orf34 STRN AKT1 JAK3 SOS2 SRC PIK3CD CDC42 MAPK8 RAC1 NRAS AKT3 INSL3 MAPK1 HRAS MAP2K1 MAP2K2 PLCG1 GAB1 PTK2 RAPGEF1 BAD CRK KRAS BRAF GRB2 SOS1 RAF1 CBL HGF ETS1 MET TFE3 PIK3R3 PTPN11 PIK3R2 PIK3R1 PIK3CB PIK3CA RAP1B RAP1A CRKL JUN STAT3 MAPK3 PAK1 ID SIGNALING PATHWAY%WIKIPATHWAYS_20200510%WP53%HOMO SAPIENS ID signaling pathway RB1 ELK1 ID2 ID1 CDK2 RBL1 PAX2 ELK3 ID3 SREBF1 MYOD1 RBL2 ELK4 PAX8 PAX5 CCNE1 NETRIN-UNC5B SIGNALING PATHWAY%WIKIPATHWAYS_20200510%WP4747%HOMO SAPIENS Netrin-UNC5B signaling Pathway AGAP2 CASP3 AKT1 IL10 RGMA ROBO4 PRKCA ARHGEF12 UNC5B INPP5D DCSTAMP NTN4 TP53 RLF NTN3 ALPL SRC NTN1 KIAA1524 PLEKHH1 MYF5 RAC1 MAPK1 PPP2R1B MAP2K1 MAP2K2 KDR NEO1 PTK2 COL1A1 RHOA RAF1 PTK2B DAPK1 FYN PTPN11 PIK3CA ICAM1 YAP1 CCL2 PPP2R4 CTGF CDH5 PPP1CA MAPK14 TNF ITGB4 VCAM1 JUN MAPK3 IL1A SELE FOLATE METABOLISM%WIKIPATHWAYS_20200510%WP176%HOMO SAPIENS Folate Metabolism CRP PLAT PLG APOB INSR ALB SAA1 FGB SAA2 FGA FGG GPX4 TP53 IL4 SLC46A1 FOLR1 GART MTR MAT1A IZUMO1R FOLR3 FOLR2 GPX1 GPX3 SOD2 NFKB2 SOD3 DHFR MTHFD1 SHMT2 SOD1 MTHFD2 SHMT1 CBS MIR6886 CAT LDLR MIR6778 SERPINE1 IL2 CTH ABCA1 HBA1 NOS1 APOA1 GPX2 F7 MTRR AHCY MTHFS ICAM1 CCL2 IFNG F2 INS MTHFR CSF1 SCARB1 HBB MPO SLC19A1 FLAD1 RFK TNF GPX6 RELA NFKB1 SAA3P SAA4 IL6 IL1B CEREBRAL ORGANIC ACIDURIAS, INCLUDING DISEASES%WIKIPATHWAYS_20200510%WP4519%HOMO SAPIENS Cerebral Organic Acidurias, including diseases IDH2 GCDH ADHFE1 ALDH7A1 D2HGDH L2HGDH MDH2 RALA DOWNSTREAM REGULATED GENES%WIKIPATHWAYS_20200510%WP2290%HOMO SAPIENS RalA downstream regulated genes EXOC2 RALBP1 HRAS YBX3 RAC3 EXOC8 RALA RAC2 KRAS CDC42 NRAS RAC1 MIRNA REGULATION OF PROSTATE CANCER SIGNALING PATHWAYS%WIKIPATHWAYS_20200510%WP3981%HOMO SAPIENS miRNA regulation of prostate cancer signaling pathways CDKN1A CASP9 CCND1 GSK3B TP53 KLK3 CREBBP AKT3 MAPK1 MAP2K1 MAP2K2 CTNNB1 BAD KRAS GRB2 SOS1 RAF1 MIR589 NFATC2IP CDKN1B MIR4664 CREB3L1 MIR30D MIR3682 MIR603 PDGFRB MIR3714 MIR4325 MIR1299 MTOR PLCL2 MIR4517 MIR466 MIR4311 MIR3664 MDM2 MIR106A BCL2 MIR20B MIR92A2 MIR19B2 PIK3CA AR TCF7 PDGFA NFKB1 NFKBIA MIRLET7BHG MIRLET7B FOXO1 MIR4763 IKBKG EICOSANOID SYNTHESIS%WIKIPATHWAYS_20200510%WP167%HOMO SAPIENS Eicosanoid Synthesis ALOX5 LTA4H ALOX15 PNPLA8 ALOX5AP PLA2G4B GGTLC2 ALOX15B PLA2G4A PTGS2 GGTLC1 DPEP1 GGT1 PTGES2 GGT2 GGTLC3 PNPLA3 PLA2G2A PTGS1 PTGIS PLA2G5 PTGDS PLA2G6 TBXAS1 PTGES ALOX12 LTC4S HEART DEVELOPMENT%WIKIPATHWAYS_20200510%WP1591%HOMO SAPIENS Heart Development ERBB3 NFATC4 FOXA2 FOXH1 BMP10 TBX20 IRX4 ISL1 TBX5 TBX2 BHLHE40 NOTCH1 GATA6 MIR145 HAND2 HAND1 FOXC2 BMP4 FOXC1 MEF2C PTPN11 BMPR2 SRF GATA4 HEY1 SMAD1 VEGFB VEGFC MAPK1 VEGFA BMP2 CTNNB1 NKX2-5 TBX1 SMAD4 NFATC3 BMPR1A NFATC1 SHH HEY2 FGF8 SMYD1 NFATC2 FGF10 MIR1-1 PITX2 TNF RELATED WEAK INDUCER OF APOPTOSIS (TWEAK) SIGNALING PATHWAY%WIKIPATHWAYS_20200510%WP2036%HOMO SAPIENS TNF related weak inducer of apoptosis (TWEAK) Signaling Pathway RELB TRAF3 CASP8 AKT2 BIRC2 GSK3B CASP3 TRAF2 AKT1 RIPK1 BIRC3 MAP3K14 HDAC1 FADD TNFRSF12A TNFSF12 MAP3K7 NFKBIB MAPK9 MAPK8 RAC1 MAPK1 MMP9 CCL2 TRIM63 TRAF5 CTNNB1 CHUK CCL5 RAF1 CASP7 MAPK14 NFKB2 TNF RELA NFKB1 IKBKB JUN NFKBIA MAPK3 IL6 TRAF1 MBDNF AND PROBDNF REGULATION OF GABA NEUROTRANSMISSION%WIKIPATHWAYS_20200510%WP4829%HOMO SAPIENS mBDNF and proBDNF regulation of GABA neurotransmission CREM GABRB2 GABRB3 AP2A1 SLC12A5 PIK3R3 PIK3R2 PIK3CG PIK3R1 PTEN PIK3CB PIK3CA AP2B1 NTRK2 PLCG1 GABRD GABRA1 GABRB1 AP2A2 GABRE GABRA2 GABRQ GABRA3 RHOA GABRP GABRA6 BDNF GABRA5 GABRA4 CREB1 GABRG3 ROCK1 GABRG1 SHC1 MIR224 STAT3 JAK2 NGFR GABRG2 INTRACELLULAR TRAFFICKING PROTEINS INVOLVED IN CMT NEUROPATHY%WIKIPATHWAYS_20200510%WP4856%HOMO SAPIENS Intracellular trafficking proteins involved in CMT neuropathy RAB4A MPZ RAB7A RAB3A NEFL EGR2 PMP22 DNM2 RAB3B MTMR2 LRSAM1 HSPB8 HSPB1 LITAF FGD4 RAB25 SH3TC2 MFN2 KIF1B RABAC1 SBF2 RAB4B GDAP1 RAB11A FIG4 RAB11B NDRG1 CANONICAL AND NON-CANONICAL NOTCH SIGNALING%WIKIPATHWAYS_20200510%WP3845%HOMO SAPIENS Canonical and Non-canonical Notch signaling MFAP1 MAML3 NOTCH2 NOTCH3 DLK1 NOTCH1 NOTCH4 PSEN2 DNER PSEN1 LEF1 DLL1 DLL3 DLL4 HEY1 JAG2 HES1 JAG1 RRAS CHUK MAML2 MAML1 RBPJ CNTN6 ADAM10 DLK2 MFAP2 NEURODEGENERATION WITH BRAIN IRON ACCUMULATION (NBIA) SUBTYPES PATHWAY%WIKIPATHWAYS_20200510%WP4577%HOMO SAPIENS Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway WDR45 RB1CC1 ATG14 DCAF17 C19orf12 ULK1 GTPBP2 ATG16L1 PIK3C3 COASY ATG4A ATG7 FA2H ATG2A ATP13A2 RHEB RPTOR STK11 SCP2 CP FTL ATG101 WIPI2 MECP2 DEPTOR ATG5 SPTLC1 MLST8 TSC2 TSC1 PRKAA1 AKT1S1 PLA2G6 BECN1 ATG3 PIK3R4 ACACA ATG10 WIPI1 ATG13 MTOR ATG12 PANK2 MAP1LC3A METHIONINE METABOLISM LEADING TO SULPHUR AMINO ACIDS AND RELATED DISORDERS%WIKIPATHWAYS_20200510%WP4292%HOMO SAPIENS Methionine metabolism leading to Sulphur Amino Acids and related disorders MAT2B ADK MTR GNMT MAT1A CSAD CBS BHMT CDO1 CTH AHCY ALZHEIMERS DISEASE%WIKIPATHWAYS_20200510%WP2059%HOMO SAPIENS Alzheimers Disease LPL SNCA ADAM17 GSK3B MAPT FAS MIR29B1 GRIN2D PSEN2 MIR708 MIR671 PSEN1 CHP2 MIR138-1 MIR9-3 MIR9-2 APH1A MIR135A1 NCSTN MIR135A2 MIR326 NAE1 MIR329-2 CACNA1D GRIN2C MIR184 CACNA1C GRIN2B MIR182 MAPK1 CACNA1F MIR129-1 LINC00461 ATP2A1 IDE MIR3176 GAPDH MME CHPF2 USMG5 MIR125A CACNA1S BACE1 MIR219B MIR1307 MIR124-1 MIR124-2 MIR1285-2 MIR124-3 LRP1 MIR769 MIR134 APBB1 LINC00599 MIR218-1 MIR199B CAPN1 MIR218-2 MIR139 CDK5 TNFRSF1A NOS1 CDK5R1 ATP2A2 CAPN2 APOE PLCB1 HSD17B10 AGER ATF6 MAPK3 MIR21 VMP1 MIR33B CASP9 CASP8 CASP3 TP53 MIR101-1 CASP12 ATP2A3 RYR3 BID CHP1 MIR95 BAD CALML5 ERN1 ITPR1 ITPR2 CASP7 ITPR3 CYCS CALML3 PLCB3 PLCB4 APAF1 PLCB2 MIR125B1 MIR181A2 MIR181A1 MIR10A MIR431 GNAQ FADD MIR132 MIR181B1 MIR181D MIR181B2 EIF2AK3 GRIN2A PPP3R2 GRIN1 PPP3CB TNF PPP3CC APP ADAM10 CALM3 CALM1 CALM2 PPP3CA PPP3R1 PSENEN IL1B EIF5A REGULATION IN RESPONSE TO INHIBITION OF THE NUCLEAR EXPORT SYSTEM%WIKIPATHWAYS_20200510%WP3302%HOMO SAPIENS eIF5A regulation in response to inhibition of the nuclear export system EIF5A IGF2BP1 XPO1 XPO4 NUCLEAR RECEPTORS META-PATHWAY%WIKIPATHWAYS_20200510%WP2882%HOMO SAPIENS Nuclear Receptors Meta-Pathway CDK1 ALOX5AP IL11 SLC6A1 CUL1 CPT1A PRDX1 GPAM NR0B2 MIR1281 ME1 KLK15 SQSTM1 STOM SLC2A12 TGFBR3 POU5F1 GCC1 TNS4 SDPR SLC39A9 SEC14L1 SLC39A6 SLC19A2 SLC39A5 PLK2 AKAP13 SLC39A7 CPEB4 SLC39A2 EPB41L4B SLC39A1 ENC1 SLC39A4 ANKRD1 IL17B SLC39A3 SLC6A17 FGFBP1 SLC6A16 EDN2 SLC6A15 TSC22D3 SLC6A14 MYOF SLC6A13 SERPINB9 SLC6A11 SLC7A5 SLC5A6 B3GNT5 IRS2 SLC5A7 CDC42EP3 AHRR ALDH3A1 SLC5A9 PMP2 CES3 GSTM1 MIR7706 AMIGO2 EPHA3 GPR153 MGST3 SERTAD2 GSTA1 MGST2 PTGES3 TXN KTN1 SLCO2B1 CES5A SLC5A3 AIP SLC5A4 SCNN1A GSTM4 SLC26A2 GSTM3 ABHD2 PRDX6 IP6K3 DNAJC15 SLC2A9 SLC6A5 SPINK13 SLC6A6 ARL5B SLC6A7 SRGN SLC6A8 CAP2 NAV3 SLC6A9 ADGRF4 MAFG UGT2B4 MAFF PRRG4 GSTM5 LRRC8A SERPINA1 ACKR3 SRXN1 SPRY1 SLC2A5 S100P SLC2A6 SLC6A2 SLC2A7 ABCB1 SLC2A8 ABCB4 SLC2A14 SLC2A11 NR1I3 MIR1181 SLC2A10 CYP4A22 NR1I2 ABCC5 CDC37 SLC2A13 ABCB11 FOXO1 SLC39A11 CYP7A1 EPHA2 SLC39A10 PPP1R14C CYP2B6 SLC39A13 SLC39A12 ABCC3 ABCG5 CES4A GSTP1 EGR1 SLC5A11 CYP4A11 SLC5A12 NR1H4 SLC5A10 PTGR1 DNAJB1 CYP8B1 UGT1A7 CYP2C9 CBR3 TXNRD3 CYP1A2 GSTA4 GSTA3 ACOX1 PPARA RGS2 PPARD SLC2A1 IL12A ABCC4 SLC6A19 SLC6A18 KAT2B ZIC2 SULT2A1 MGST1 SLC5A8 GSTT2 NCOA2 HSP90AA1 HMOX1 NRG1 JUNB CBR1 UGT1A6 NQO1 SMARCA1 GPX3 TXNRD1 GSR HGF SOD3 SLC5A1 PDE4B SP1 SLC5A2 SLC6A20 CYP1A1 SLC5A5 NFE2L2 JUND IL2 ETNK2 GGTLC2 GGTLC1 GCLC SLC27A1 GGT1 GGT2 DBI SCP2 GGTLC3 HSP90AB1 GSTM2 APOA2 G6PD APOA1 GPX2 APOA5 GSTA5 ANGPTL4 BAAT SLC27A5 PLTP HES1 APOC3 FABP1 ALAS1 CYP2C19 SULT1A1 PPP2R4 IFNG UGT1A4 HBEGF UGT1A3 PPARGC1A NCOA1 NCOA6 SMC1A CYP2A6 DNAJC7 BLVRB GSTA2 VDR EHHADH NR3C1 TNF RXRA IL1B CPT2 ESR1 TNFAIP3 HSPA1A THBD DNER SRC EGFR PDGFB ARNT TGFB2 NFKB2 CDKN1B FGF13 MFGE8 SERPINB2 KEAP1 TGFBR2 SREBF1 SLC6A4 NR1H3 SLC2A2 CCL2 CDKN1C SCD FASN SLC6A3 AGER AHR CYP1B1 UGT2B7 STAT3 IL12B SLC7A11 CCND1 FTH1 POLK SLC39A8 BHLHE40 SLC39A14 PGD PDK4 ACADM SNAI2 ACAA1 TGFA FTL ABCC2 UGT1A1 CYP3A4 CYP3A5 SLCO1B1 NRIP1 UGT1A9 CES2 CES1 GADD45B ADH7 CDK4 BAX ABCG8 SLC10A1 FGF19 PCK1 TGFB1 CYP3A7 SRPX2 NCOA3 CYP4F12 SLC2A3 BIRC2 PTGS2 PSMC5 BIRC3 IGFBP1 MYC GCLM FGD4 FKBP5 SLC2A4 JUN EP300 CCL20 PHYTOCHEMICAL ACTIVITY ON NRF2 TRANSCRIPTIONAL ACTIVATION%WIKIPATHWAYS_20200510%WP3%HOMO SAPIENS Phytochemical activity on NRF2 transcriptional activation SLC7A11 MAF HMOX1 GCLC KEAP1 NQO1 EPHB2 GSTA2 CEBPB PRKCA GCLM PIK3CA MAPK8 NFE2L2 AIMP2 PRADER-WILLI AND ANGELMAN SYNDROME%WIKIPATHWAYS_20200510%WP3998%HOMO SAPIENS Prader-Willi and Angelman Syndrome RB1 SNURF MAGEL2 CCND1 HTR2C CYFIP1 OXT TP53 PCSK1 E2F1 GABRR3 NPAP1 GABRR1 HERC2 SNORD109B SNORD109A PWRN1 SNRPN GABRD FSHB NIPA1 SNORD107 NIPA2 FEZ1 FEZ2 CDKN2A OCA2 SLC45A2 LHB ATP10A CDK6 NHLH2 BDNF CDK4 NDN CGA TYR TUBGCP5 MKRN3 SNORD64 PCM1 CDC6 KISS1 CDKN2B CDKN2C MDM2 MDM4 POMC NGF GABRB3 CCND2 GNRH1 GABRR2 DLX5 MSX1 INS GHRH GHRL GABRA5 UBE3A GABRG3 GABRG1 TACR3 PRKCZ BBS4 GABRG2 COVID-19 AOP%WIKIPATHWAYS_20200510%WP4891%HOMO SAPIENS COVID-19 AOP CXCL10 ACE2 CCL2 CSF3 IL2 IL10 TMPRSS2 IL7 CCL3 IL2RA TNF AGT CXCL8 IL6 IL1B INTERLEUKIN-11 SIGNALING PATHWAY%WIKIPATHWAYS_20200510%WP2332%HOMO SAPIENS Interleukin-11 Signaling Pathway RPS6 TGFB1 RPS6KB1 IL11 YES1 IL11RA PIAS1 AKT1 TYK2 BCL2 FYN PTPN11 FES SRC PIK3R2 ITGA2 PIK3R1 PIAS3 STAT1 ICAM1 MAPK1 HRAS IL6ST MAP2K1 PDPK1 RPS6KA1 MAP2K2 PPP2R4 BGLAP BIRC5 IBSP ATF1 GRB2 CHUK RAF1 CREB1 RELA IKBKB STAT3 JAK2 MAPK3 JAK1 SOCS3 RUNX2 PANCREATIC ADENOCARCINOMA PATHWAY%WIKIPATHWAYS_20200510%WP4263%HOMO SAPIENS Pancreatic adenocarcinoma pathway RB1 PAK7 CDKN1A PAK6 ARAF CASP9 PAK3 PAK2 CCND1 AKT2 PAK4 AKT1 POLK DDB2 RAD51 TP53 TGFA SMAD2 PIK3CD RAC2 EGFR MAPK9 CDC42 MAPK8 ERBB2 RAC1 E2F1 AKT3 E2F2 MAPK1 E2F3 MAP2K1 BAK1 MAP2K2 GADD45B GADD45A PRKCD BAD MAPK10 CDKN2A RALB EGF KRAS RHOA BRAF GADD45G TGFB2 CDK6 RALBP1 RAF1 CDK4 BAX BCL2L1 BRCA2 MTOR TGFB1 RPS6KB1 TGFB3 RPS6KB2 ARHGEF6 TGFBR1 TGFBR2 PEBP1 RIPK4 PLD1 PIK3R3 PIK3R2 RALA PIK3R1 PIK3CB RALGDS PIK3CA STAT1 VEGFA SMAD4 SMAD3 CHUK TIAM1 RAC3 RELA NFKB1 IKBKB STAT3 DUSP6 MAPK3 JAK1 PAK1 IKBKG SUPRESSION OF HMGB1 MEDIATED INFLAMMATION BY THBD%WIKIPATHWAYS_20200510%WP4479%HOMO SAPIENS Supression of HMGB1 mediated inflammation by THBD THBD AGER HMGB1 RELA NFKB1 IKBKB NFKBIA CHUK IKBKG STATIN PATHWAY%WIKIPATHWAYS_20200510%WP430%HOMO SAPIENS Statin Pathway LPL ABCG5 MIR33B HMGCR APOB MIR33A LIPC MTTP DGAT1 FDFT1 ABCA1 APOC4-APOC2 PDIA2 APOA2 MIR6848 APOA1 APOA4 APOA5 APOC1 PLTP APOC3 SQLE CETP SOAT1 LCAT APOE SCARB1 LRP1 ABCG8 MIR6886 ACSS1 LDLR CYP7A1 APOE AND MIR-146 IN INFLAMMATION AND ATHEROSCLEROSIS%WIKIPATHWAYS_20200510%WP3926%HOMO SAPIENS ApoE and miR-146 in inflammation and atherosclerosis TRAF6 IRAK1 TLR4 NFKB2 RELA APOE MIR718 SPI1 TLR2 PURINERGIC SIGNALING%WIKIPATHWAYS_20200510%WP4900%HOMO SAPIENS Purinergic signaling LPAR4 GNAO1 LPAR6 ADORA2A P2RY8 P2RY6 PANX1 P2RY4 GNAT2 ADORA2B GNAT3 P2RY2 ADORA3 GNAT1 P2RY1 P2RY12 P2RY10 GNAI1 P2RY14 P2RX7 MIR197 P2RX5 P2RX4 P2RX3 P2RX2 P2RX1 GNAI3 GNAZ ADORA1 P2RX6 GNAS GNAI2 P2RY13 P2RY11 ALANINE AND ASPARTATE METABOLISM%WIKIPATHWAYS_20200510%WP106%HOMO SAPIENS Alanine and aspartate metabolism GOT2 GAD2 ASS1 DARS ABAT GPT AGXT PC ASPA ASL GAD1 GOT1 RAC1/PAK1/P38/MMP2 PATHWAY%WIKIPATHWAYS_20200510%WP3303%HOMO SAPIENS RAC1/PAK1/p38/MMP2 Pathway ANGPTL1 EIF4EBP1 GRB7 TIE1 TNIP1 CASP9 TNIP2 TNIP3 AKT1 DOK2 RAD51 TP53 ITGB1 SRC PXN EGFR MAPK9 MAPK8 ERBB2 RAC1 NRAS ANGPT1 MAPK1 HRAS FN1 STAT5A PTK2 STAT5B MAPK12 CTNNB1 MAPK13 TEK BAD CRK MAPK11 KRAS GRB2 SOS1 CASP7 BAX ANGPT2 NOS2 MYC NOS1 RASA1 PTPN11 PIK3R1 PIK3CA STMN1 GRB14 NCK1 YAP1 MMP2 BIRC5 MIR3917 CHUK MAPK14 ANGPT4 RELA NFKB1 IKBKB NFKBIA STAT3 MAPK3 FOXO1 PAK1 MSH2 RS1 IKBKG SOMATIC SEX DETERMINATION%WIKIPATHWAYS_20200510%WP4814%HOMO SAPIENS Somatic Sex determination DHH DMRT1 SOX9 FOXL2 NR5A1 WT1 PTGDS FGF9 WNT4 MIR4321 GATA4 SOX8 RSPO1 SRY AMH SREBF AND MIR33 IN CHOLESTEROL AND LIPID HOMEOSTASIS%WIKIPATHWAYS_20200510%WP2011%HOMO SAPIENS SREBF and miR33 in cholesterol and lipid homeostasis MIR33B SREBF2 MIR33A HMGCR SIRT6 SCD FASN PPARGC1A PPARA ABCA1 PRKAA1 SREBF1 MED15 HMGCS1 SIRT1 MIR6886 LDLR NR1H3 MTOR T-CELL ANTIGEN RECEPTOR (TCR) SIGNALING PATHWAY%WIKIPATHWAYS_20200510%WP69%HOMO SAPIENS T-Cell antigen Receptor (TCR) Signaling Pathway CD83 CD247 IL9 LCK REL AKT1 FAS PSTPIP1 IL15RA GAB2 MAP3K14 DBNL MIR6837 SKAP1 TNFRSF9 GATA3 MAPK9 CDC42 MAPK8 MAP4K1 ZAP70 MAPK1 HRAS MAP2K1 PDPK1 CD8A MAP2K2 PLCG1 VIM CD3D GRAP2 PRKCD LCP2 CRK CARD11 ATF2 BCL10 MALT1 GRB2 ICOS SOS1 CD4 RAF1 ITPR1 CBL PRKCQ PTK2B LAT FOS IL17A SH2B3 VAV3 TGFB1 TRAF6 FYN MAP3K7 PTPN11 RIPK2 PIK3R2 PIK3R1 CBLB CD28 ITK IRF4 NCK1 FYB VAV1 MAP3K8 WAS CCR5 CHUK NFATC1 CRKL MAPK14 CREB1 RELA SHC1 NFKB1 IKBKB OPRM1 JUN NFKBIA MAPK3 PAK1 CD3G IL1A IL6 NFATC2 CD3E IKBKG IL1B METABOLISM OF SPINGOLIPIDS IN ER AND GOLGI APPARATUS%WIKIPATHWAYS_20200510%WP4142%HOMO SAPIENS Metabolism of Spingolipids in ER and Golgi apparatus CERK SGMS2 SGPP2 SGPP1 UGT8 UGCG SGPL1 B3GALT1 B4GALNT1 SPHK2 SPHK1 KDSR B4GALT2 B3GALNT1 GALNT16 B4GALT1 GALNT1 CERS3 B3GALT2 ST6GALNAC3 IL17 SIGNALING PATHWAY%WIKIPATHWAYS_20200510%WP2112%HOMO SAPIENS IL17 signaling pathway TRAF3 GSK3B IL25 AKT1 MAP3K14 IL17F IL17D CEBPB TRAF6 IL17C IL17B MAP3K7 NFKBIB PIK3CA MAPK1 TRAF3IP2 IL17RE IL17RD IL17RC IL17RB IL17RA CEBPD IL17A RELA NFKB1 SP1 IKBKB STAT3 JAK2 MAPK3 JAK1 IKBKG NAD METABOLISM, SIRTUINS AND AGING%WIKIPATHWAYS_20200510%WP3630%HOMO SAPIENS NAD metabolism, sirtuins and aging NAMPT HIF1A SIRT1 SIRT3 NFKB1 TFAM PARP1 FOXO3 PPARG ROS1 FOXO1 UREA CYCLE AND ASSOCIATED PATHWAYS%WIKIPATHWAYS_20200510%WP4595%HOMO SAPIENS Urea cycle and associated pathways GOT2 PYCR1 ASS1 CPS1 ASL NAGS NOS2 GLS2 SLC25A15 FH SLC25A13 ALDH4A1 OTC GLUD1 OAT GPT LDHB MDH1 GOT1 MDH2 ARG1 FGF23 SIGNALLING IN HYPOPHOSPHATEMIC RICKETS%WIKIPATHWAYS_20200510%WP4790%HOMO SAPIENS FGF23 signalling in Hypophosphatemic rickets CDKN1A SLC34A1 ENPP1 CCND1 CYP24A1 ROS1 FGF23 DMP1 NFKB2 GALNT3 NFKB1 PHEX ALPL FAM20C SLC34A3 KL FGFR3 CYP11B2 FGFR2 PTH CYP27B1 SPP1 LAMIN A-PROCESSING PATHWAY%WIKIPATHWAYS_20200510%WP4299%HOMO SAPIENS Lamin A-processing pathway LMNA ICMT ZMPSTE24 INSULIN SIGNALLING IN HUMAN ADIPOCYTES (DIABETIC CONDITION)%WIKIPATHWAYS_20200510%WP3635%HOMO SAPIENS Insulin signalling in human adipocytes (diabetic condition) RPS6 RPS6KB1 IRS1 TBC1D4 INSR AKT2 MTOR SLC2A4 NONALCOHOLIC FATTY LIVER DISEASE%WIKIPATHWAYS_20200510%WP4396%HOMO SAPIENS Nonalcoholic fatty liver disease LEP GSK3B PRKAG1 FAS PRKAG2 PRKAG3 CEBPA PRKAB2 PRKAB1 PIK3CD ADIPOR1 MAPK9 CDC42 MAPK8 ADIPOR2 AKT3 ITCH MLXIPL NDUFA11 NDUFA10 NDUFC2-KCTD14 COX6B2 KCTD14 NDUFB11 PKLR CYC1 COX7B2 FASLG NDUFC2 COX4I2 NDUFC1 MLX COX8C NDUFS8 MLXIP NDUFS7 NDUFS6 NDUFS5 NDUFS4 TRAF2 NDUFS3 NDUFS2 NDUFA13 NDUFS1 MIR4691 TNFRSF1A MT-CO1 NDUFB9 NDUFB8 NDUFB7 NDUFB10 SREBF1 NDUFB6 IRS1 SMAD7 NDUFB5 NDUFB4 PIK3R3 NDUFA4L2 PIK3R2 NDUFB2 IRS2 PIK3R1 PIK3CB NDUFB1 PIK3CA NR1H3 ADIPOQ NDUFV3 NDUFV2 MIR7113 NDUFV1 CCL2 NDUFA9 NDUFA8 NDUFA7 NDUFA6 NDUFA5 NDUFA4 NDUFA2 MT-CO2 NDUFAB1 VCAM1 SOCS3 MIR21 VMP1 XBP1 NR1H4 INSR CASP8 AKT2 CASP3 AKT1 CYP2E1 PPARA MAP3K11 GSK3A CXCL8 RAC1 SDHA BAK1 BID MAP3K5 IL6R ERN1 PRKAA1 BBC3 CASP7 BAX CYCS PRKAA2 NDUFA12 COX6A1 COX6A2 SDHC SDHD TGFB1 SDHB COX6B1 COX7A2L ATF4 UQCRC1 MT-CO3 UQCRC2 UQCRB MIR3191 COX7A2 COX7A1 MIR3190 UQCRH UQCRQ MT-CYB COX7B COX4I1 COX7C UQCRFS1 COX8A NDUFB3 UQCR11 UQCR10 COX5B EIF2AK3 COX5A EIF2S1 NDUFA1 DDIT3 BCL2L11 INS COX6C TNF RELA NFKB1 IKBKB JUN LEPR IL6 IL1A RXRA IL1B NRF2-ARE REGULATION%WIKIPATHWAYS_20200510%WP4357%HOMO SAPIENS NRF2-ARE regulation RBX1 INSR SLC7A11 MAF YES1 HMOX1 GSK3B GCLC KEAP1 NQO1 CUL3 EPHB2 GSTA2 CEBPB PRKCA PGAM5 FYN GCLM SRC PIK3CA MAPK8 NFE2L2 AIMP2 MED AND PSEUDOACHONDROPLASIA GENES%WIKIPATHWAYS_20200510%WP4789%HOMO SAPIENS MED and Pseudoachondroplasia genes MATN1 MATN3 COMP COL9A1 COL9A3 COL9A2 PDGF PATHWAY%WIKIPATHWAYS_20200510%WP2526%HOMO SAPIENS PDGF Pathway PLA2G4A RASA1 ARFIP2 PTPN11 SRC PIK3R1 SRF STAT1 CDC42 MAPK8 RAC1 ELK1 WASL MAPK1 PDGFB HRAS MAP2K1 PLCG1 VAV1 VAV2 PDGFA MAP2K4 MAP3K1 MT-CO2 RHOA GRB2 CHUK TIAM1 SOS1 RAF1 FOS SHC1 NFKB1 JUN NFKBIA STAT3 MAPK3 PDGFRB PAK1 JAK1 SEROTONIN TRANSPORTER ACTIVITY%WIKIPATHWAYS_20200510%WP1455%HOMO SAPIENS Serotonin Transporter Activity PPP2CB IL1R1 ITGB3 TPH2 NOS1 MAOA SLC6A4 STX1A SCAMP2 TGFB1I1 IL1B FLUOROPYRIMIDINE ACTIVITY%WIKIPATHWAYS_20200510%WP1601%HOMO SAPIENS Fluoropyrimidine Activity TYMP ABCC3 DPYD UMPS SLC22A7 TP53 PPAT SLC29A1 TDG CDA ABCC4 FPGS UPP2 ERCC2 TK1 UPP1 TYMS XRCC3 GGH SMUG1 UCK2 UCK1 CES2 CES1 ABCG2 MTHFR CYP2A6 DHFR RRM1 ABCC5 RRM2 DPYS UPB1 OSTEOBLAST SIGNALING%WIKIPATHWAYS_20200510%WP322%HOMO SAPIENS Osteoblast Signaling ITGB3 TNFRSF11B ITGAV PDGFB BGLAP TNFSF11 COL1A1 IBSP FGF23 SLC17A2 PTH1R PDGFRB PDGFRA PTH SPHINGOLIPID PATHWAY%WIKIPATHWAYS_20200510%WP1422%HOMO SAPIENS Sphingolipid pathway SGPL1 PPAP2A PPP2CA CERS3 CERS4 CERS5 CERS6 CERK SGMS2 SGPP2 UGT8 ASAH1 UGCG SPTLC1 SPTLC2 SPHK2 SPHK1 KDSR CERS2 GAL3ST1 ASAH2 GBA PPP1CA GBA2 COL4A3BP SGMS1 SPTLC3 ACER1 SERINC1 B4GALT6 BIOMARKERS FOR UREA CYCLE DISORDERS%WIKIPATHWAYS_20200510%WP4583%HOMO SAPIENS Biomarkers for urea cycle disorders F10 GLS2 OTC ASS1 GPT GAMT GATM F7 ASL NAGS GOT1 ARG1 PRIMARY FOCAL SEGMENTAL GLOMERULOSCLEROSIS FSGS%WIKIPATHWAYS_20200510%WP2572%HOMO SAPIENS Primary Focal Segmental Glomerulosclerosis FSGS ILK MKI67 CDKN1A KIRREL3 KIRREL2 UTRN LIMS3L LIMS3 LIMS1 AKT1 NOTCH1 CAMK2B DNM1 ITGB1 CDH2 LRP5 PLCE1 LRP6 SMARCAL1 JAG1 PLCG1 VIM MME PTK2 CTNNB1 SCARB2 CD151 PTPRO PODXL MIR6852 AGRN TLN1 SYNPO TLR4 CDKN1B TRPC6 COL4A4 COL4A3 COL4A5 CTSL MYO1E CLDN1 INF2 TGFB1 MYH9 VTN IRF6 ACTN4 FYN CR1 FAT1 PLAUR CD80 PARVA DKK1 ITGB3 ITGAV NCK1 VCL LAMA5 CDKN1C LAMB2 ITGA3 PAX2 CD2AP NPHS1 WT1 NPHS2 PCNA LMX1B WNT1 ITGB4 DAG1 MIR4758 YWHAQ KRT8 GLUCURONIDATION%WIKIPATHWAYS_20200510%WP698%HOMO SAPIENS Glucuronidation UGT1A7 UGT2B28 PGM3 UGT1A5 UGT2A3 UGT2A2 PGM5 UGT2A1 UGT2B10 UGT2B11 UGT2B17 UGDH UGT1A10 UGT1A1 UGP2 UGT1A9 HK1 PGM2 UGT1A4 PGM1 UGT1A3 UGT1A6 UGT2B4 UGT2B15 UGT1A8 UGT2B7 NAD+ BIOSYNTHETIC PATHWAYS%WIKIPATHWAYS_20200510%WP3645%HOMO SAPIENS NAD+ biosynthetic pathways PARP4 TNKS QPRT SIRT6 SIRT4 SIRT5 SIRT7 PARP1 NADSYN1 SIRT2 BST1 NMNAT1 TNKS2 NAPRT CD38 ACMSD NAMPT TDO2 SIRT1 SIRT3 IDO1 PARP2 ARRHYTHMOGENIC RIGHT VENTRICULAR CARDIOMYOPATHY%WIKIPATHWAYS_20200510%WP2118%HOMO SAPIENS Arrhythmogenic Right Ventricular Cardiomyopathy ITGB8 DSC2 ITGB7 ITGB6 DMD SLC8A1 RYR2 CTNNA3 CTNNA2 ITGB1 CDH2 CACNB1 LEF1 CACNB2 CACNB3 CACNB4 CACNA1D TCF7L2 CACNA1C TCF7L1 GJA1 CACNA1F ITGA1 ITGA2B CTNNB1 CACNA1S LMNA ACTN3 DSG2 DES JUP ACTN1 ACTN4 ITGA10 ITGA11 CACNG6 CACNG7 CACNG8 ITGA4 ITGA2 ATP2A2 CACNG1 CACNG2 CACNG3 ITGA7 CACNG4 ACTN2 ITGA6 CACNG5 ITGB3 ITGAV CACNA2D1 ITGA5 MIR935 ACTB CACNA2D3 ACTG1 CACNA2D2 ITGA9 CACNA2D4 LAMA2 ITGA3 TCF7 ITGA8 PKP2 ITGB5 ITGB4 EMD DAG1 SGCD DSP SGCA SGCB SGCG CTNNA1 CARDIAC PROGENITOR DIFFERENTIATION%WIKIPATHWAYS_20200510%WP2406%HOMO SAPIENS Cardiac Progenitor Differentiation MYH6 SCN5A GSK3B SOX1 NOTCH1 BMP1 KIT PDGFRA MYLK3 FGF2 KDR NRG1 NKX2-5 NANOG NODAL ACTC1 MESP2 FOXA2 TGFB1 MESP1 TNNT2 NOG ZFP42 THY1 POU5F1 T TBX20 SIRPA ISL1 TNNI3 IRX4 TBX5 LIN28B LIN28A MYL2 SOX17 INHBA NCAM1 IGF2 BMP4 ANPEP MEF2C CXCR4 GATA4 DKK1 PAX6 IGF1 ROR2 MIXL1 INS MAPK14 SOX2 WNT3A THYROXINE (THYROID HORMONE) PRODUCTION%WIKIPATHWAYS_20200510%WP1981%HOMO SAPIENS Thyroxine (Thyroid Hormone) Production TRH CGA TPO SLC5A5 TG TSHR TGIF DISRUPTION OF SHH SIGNALING%WIKIPATHWAYS_20200510%WP3674%HOMO SAPIENS Tgif disruption of Shh signaling TGIF1 TGIF2 SHH NKX2-1 GLI3 FGF8 SMAD2 FOXG1 NODAL AMPLIFICATION AND EXPANSION OF ONCOGENIC PATHWAYS AS METASTATIC TRAITS%WIKIPATHWAYS_20200510%WP3678%HOMO SAPIENS Amplification and Expansion of Oncogenic Pathways as Metastatic Traits TCF7L2 JAG1 TCF7L1 VEGFA POSTN TNC TCF7 NOTCH1 WNT2 VCAM1 CYTIP LEF1 SRC PIK3CG CXCR4 VHL EPAS1 FAS LIGAND (FASL) PATHWAY AND STRESS INDUCTION OF HEAT SHOCK PROTEINS (HSP) REGULATION%WIKIPATHWAYS_20200510%WP314%HOMO SAPIENS Fas Ligand (FasL) pathway and Stress induction of Heat Shock Proteins (HSP) regulation RB1 FASLG PRKDC CASP9 CASP8 PAK2 CASP3 FAS BCL2 ACTA1 FADD MAP3K7 FAF1 RIPK2 LMNB1 SPTAN1 HSPB1 MAPKAPK3 NFX1 MAPKAPK2 MAPK8 DAXX ACTB ACTG1 PARP1 MAP2K4 MAP3K1 CFLAR LMNA CASP7 CASP6 CYCS CASP10 TNF LMNB2 DFFB JUN DFFA PAK1 APAF1 IL1A ARHGDIB MIR7108 OLIGODENDROCYTE SPECIFICATION AND DIFFERENTIATION(INCLUDING REMYELINATION), LEADING TO MYELIN COMPONENTS FOR CNS%WIKIPATHWAYS_20200510%WP4304%HOMO SAPIENS Oligodendrocyte Specification and differentiation(including remyelination), leading to Myelin Components for CNS MIR6073 CXCL1 CXCL2 SOX6 SOX10 LIF OLIG1 OLIG2 ASCL1 BMP4 SOX8 MYT1 PLP1 CNTF CNP NKX2-6 PDGFB MOG SOX9 IGF1 FGF2 BMP2 OMG MAG TNF SHH GLI2 NKX2-2 SOX5 MBP IL1B PATHWAYS AFFECTED IN ADENOID CYSTIC CARCINOMA%WIKIPATHWAYS_20200510%WP3651%HOMO SAPIENS Pathways Affected in Adenoid Cystic Carcinoma FBXW7 NCOR1 CHEK2 CHEK1 MAML3 TLK1 AKT1 BCORL1 NOTCH1 CEBPA TP53 FOXO3 MAX ERBB2 CREBBP SETD2 HRAS DTX4 MIR1281 MAP2K2 IL17RD ARID1A SMARCA2 RAF1 SMARCE1 MYB FGF16 BRCA1 FGFR4 PRKDC ATM MYC PTEN PIK3CA BCOR ERBB2IP JMJD1C ARID4B MYBL1 CMTR2 CTBP1 KDM6A MAGI1 KDM6B HIST1H2AL SMC1A BRD1 MAGI2 INSRR ATRX ARID5B FOXP2 MORF4L1 MYCN KAT6A MYCBP CNTN6 SRCAP EP300 UHRF1 KMT2C MGA KANSL1 NSD1 NFIB HIST1H1E H19 ACTION RB-E2F1 SIGNALING AND CDK-BETA-CATENIN ACTIVITY%WIKIPATHWAYS_20200510%WP3969%HOMO SAPIENS H19 action Rb-E2F1 signaling and CDK-Beta-catenin activity RB1 JAG1 CDK8 H19 CCND1 CTNNB1 SOX4 TULP3 PMAIP1 MED1 CDK4 CSRP2 H2AFY CDH1 E2F1 GLUCOSE HOMEOSTASIS%WIKIPATHWAYS_20200510%WP661%HOMO SAPIENS Glucose Homeostasis INS FARNESOID X RECEPTOR PATHWAY%WIKIPATHWAYS_20200510%WP2879%HOMO SAPIENS Farnesoid X Receptor Pathway CYP3A4 SLCO2B1 FKBP5 NR0B2 NR1H4 SULT2A1 CYP8B1 IP6K3 PPARGC1A UGT2B4 SLC10A1 FGF19 ABCB4 IRS2 BAAT ABCB11 SLC27A5 CYP7A1 RXRA P38 MAPK SIGNALING PATHWAY%WIKIPATHWAYS_20200510%WP400%HOMO SAPIENS p38 MAPK Signaling Pathway MAP2K6 MEF2D RASGRF1 PLA2G4A TRAF2 RIPK1 TGFBR1 MYC MAP3K7 HMGN1 MKNK1 HSPB1 MAPKAPK2 STAT1 MAPKAPK5 MAX CDC42 RAC1 DAXX ELK1 RPS6KA5 HRAS MAP3K5 MAP3K9 DDIT3 MAP2K4 ATF2 MAP3K1 GRB2 TRADD TGFB2 MAPK14 CREB1 SHC1 HYPERTROPHY MODEL%WIKIPATHWAYS_20200510%WP516%HOMO SAPIENS Hypertrophy Model IL1R1 EIF4EBP1 JUND VEGFA IFNG ATF3 HBEGF IL18 ZEB1 ANKRD1 MSTN EIF4E MYOG ADAM10 CYR61 WDR1 IFRD1 NR4A3 DUSP14 IL1A ACTIVATION OF NLRP3 INFLAMMASOME BY SARS-COV-2%WIKIPATHWAYS_20200510%WP4876%HOMO SAPIENS Activation of NLRP3 Inflammasome by SARS-CoV-2 TRAF3 NLRP3 CASP1 RELA NFKB1 PYCARD IL1B MTHFR DEFICIENCY%WIKIPATHWAYS_20200510%WP4288%HOMO SAPIENS MTHFR deficiency PCYT1A CHKA CASP9 BHMT CASP3 PEMT CHPT1 HNMT GRIN2D DNMT1 DNMT3A MIR6758 NDUFAF7 MARS CHDH MIR4761 GRIN2A EHMT2 ALDH7A1 ASMT EHMT1 MTHFR COMT GRIN1 CYCS SGMS1 DNMT3B OVARIAN INFERTILITY GENES%WIKIPATHWAYS_20200510%WP34%HOMO SAPIENS Ovarian Infertility Genes EGR1 FSHR NCOR1 ATM CCND2 PGR CEBPB GJA4 TBP MLH1 BMPR1B PTGER2 SYNE2 NRIP1 FIGLA DAZL NR5A1 DMC1 SMPD1 MSH5 ZP3 INHA ZP2 CYP19A1 SMAD3 VDR CDK4 LHCGR PRLR CDKN1B ESR2 GDF9 HIJACK OF UBIQUITINATION BY SARS-COV-2%WIKIPATHWAYS_20200510%WP4860%HOMO SAPIENS Hijack of Ubiquitination by SARS-CoV-2 CBFB TCEB2 UBA3 TCEB1 RBX1 ZYG11B NAE1 CUL2 GPCRS, CLASS A RHODOPSIN-LIKE%WIKIPATHWAYS_20200510%WP455%HOMO SAPIENS GPCRs, Class A Rhodopsin-like TRHR SSTR5 MC3R CCKBR F2RL2 FSHR CX3CR1 OPRD1 NPY4R OPRL1 FPR1 CXCR5 FPR3 ADRA1B FPR2 MC2R CXCR1 GALR3 GALR2 GALR1 CXCR3 CXCR2 NTSR1 CCR10 NTSR2 CCR1 OPRK1 NMBR HCRTR2 HCRTR1 MC1R MC5R DRD2 NPFFR2 NPFFR1 RRH GPR174 GPR173 GPR171 CMKLR1 GPR37L1 OR1I1 NPBWR1 NPBWR2 OR6B1 GPR15 GPR12 OR2J3 OR2J2 OR6A2 RGL4 OR7C2 OR7C1 GPR19 GPR27 OR10J1 GPR25 GPR21 GPR22 GPR20 OPN1LW FFAR1 GPR39 OR5F1 GPR34 GPR35 GPR32 GPR31 OR5V1 OPN1MW OR3A2 OR10H1 RABGAP1 OR10H3 GPR45 OR10H2 OR2AG1 GPR52 GPR1 GPR4 GPR3 GPR6 MAS1 F2RL1 F2RL3 OR1C1 GPR65 GPR63 CCRL2 OR2D2 GPR75 OR2T1 APLNR OR1A2 ACKR3 OR1A1 OR2C1 SUCNR1 OR5I1 GPR87 GPR85 CHRM2 MCHR1 CHRM3 OR2S2 CHRM1 HCAR3 CHRM4 OR1Q1 CHRM5 HCAR1 HRH3 HTR2B HRH1 OR2B3 CYSLTR1 HRH2 OR2B2 CYSLTR2 DRD5 NMUR2 LPAR4 HTR1E NMUR1 HTR1F OR7A10 HTR1D OR14J1 HTR1B MLNR PRLHR HTR5A OR8D2 ADRA2B ADRB3 LTB4R OR2H2 GPR161 OR7A5 LPAR5 OR10A4 LPAR6 OR1E2 ADRA1D OR8B8 ADRB2 OR2W1 ADRA2C OR12D3 OR1D5 ADRA2A MAS1L OR1D4 OR1D2 OR2F2 OPN1SW ACKR4 ACKR2 OR11A1 P2RY6 P2RY4 ADORA2B P2RY2 ADORA3 P2RY1 HTR4 HTR6 HTR7 AGTR1 AGTR2 OR1G1 OR7A17 P2RY12 OR1F1 P2RY10 OR2H1 P2RY14 FFAR3 FFAR2 DRD1 OR3A3 OR3A1 DRD4 OR10A5 GPR37 OR1E1 C5AR2 GPR83 OR2B6 GPR17 P2RY13 P2RY11 OR2F1 OR2A4 GPR18 HTR1A HTR2C HTR2A PTGER4 PTGFR PTGER1 PTGER2 PTAFR PTGER3 GPR50 MTNR1A CNR2 MTNR1B CNR1 TBXA2R PTGDR DRD3 PTGDR2 CXCR4 ADRB1 GPR68 ADRA1A EDNRA EDNRB PTGIR CCR3 F2R NPY1R GPER1 ADORA1 OPN4 OPN3 ADORA2A XCR1 OXTR NPY6R NPY2R GRPR BRS3 MC4R CCKAR CCR9 C3AR1 BDKRB2 CCR8 BDKRB1 CCR7 CCR6 CCR5 CCR4 CCR2 GHSR LHCGR AVPR1B NPY5R AVPR2 OPRM1 AVPR1A RHO SSTR1 SSTR2 SSTR3 SSTR4 PHYSIOLOGICAL AND PATHOLOGICAL HYPERTROPHY OF THE HEART%WIKIPATHWAYS_20200510%WP1528%HOMO SAPIENS Physiological and Pathological Hypertrophy of the Heart MYEF2 NFATC4 PRKCE PRKCB CAMK2D GATA4 LIFR MAPK8 RAC1 MAPK1 IL6ST EDN1 CTF1 MAP2K3 MAPK11 RHOA FOS MAPK14 PPP3CB CALM3 JUN CALM1 PPP3CA STAT3 CALM2 AGT RANKL/RANK (RECEPTOR ACTIVATOR OF NFKB (LIGAND)) SIGNALING PATHWAY%WIKIPATHWAYS_20200510%WP2018%HOMO SAPIENS RANKL/RANK (Receptor activator of NFKB (ligand)) Signaling Pathway MAP2K6 CTSK TNFRSF11B RELB MAP2K7 TNFRSF11A AKT2 TNFSF11 AKT1 FHL2 GAB2 SYK SRC MAPK9 CDC42 MAPK8 RAC1 MAPK1 MAP2K1 PLCG1 PTK2 CBL FOS MITF NFKB2 SQSTM1 TAB2 TAB1 MTOR TRAF1 TRAF3 SPI1 TRAF2 TRAF6 MAP3K7 PIK3R2 PIK3R1 CALCR LYN STAT1 ICAM1 ACP5 TRAF5 CHUK NFATC1 MAPK14 RELA VCAM1 NFKB1 IKBKB PAPSS2 JUN NFKBIA MAPK3 IKBKG VITAMIN B6-DEPENDENT AND RESPONSIVE DISORDERS%WIKIPATHWAYS_20200510%WP4228%HOMO SAPIENS Vitamin B6-dependent and responsive disorders PNPO ALPI ALDH7A1 PIGV AASS EVOLOCUMAB MECHANISM%WIKIPATHWAYS_20200510%WP3408%HOMO SAPIENS Evolocumab Mechanism MIR6886 LDLR PCSK9 GASTRIC CANCER NETWORK 1%WIKIPATHWAYS_20200510%WP2361%HOMO SAPIENS Gastric Cancer Network 1 NUP107 INO80D LIN9 MCM4 KIF15 AURKA ESM1 C21orf33 MYBL2 CENPF ECT2 TPX2 SMOC2 GATS KIF20B NOTCH1 TOP2A RUVBL1 CEP192 E2F7 CCNA1 RNF216 ACTL6A APC S100P HIST4H4 UBE2C H3F3A HEMATOPOIETIC STEM CELL DIFFERENTIATION%WIKIPATHWAYS_20200510%WP2849%HOMO SAPIENS Hematopoietic Stem Cell Differentiation MIR130A RUNX1 NOTCH1 LEF1 TRAF3IP3 HMGN5 TRIM29 TNXB MIR16-1 LMO2 LYL1 RHOH CBFA2T3 ZNF835 GYPA ACVR1B KITLG GATA1 ABO CSF3 SEC14L2 MUC1 STAT5A ITGA2B MXI1 NFE2 RIOK3 FLI1 KLF1 IL5 FOS GP9 THRB MYB TPO NCKAP1L PIM1 MIR3074 MIR181A1 EPO IRF5 CIITA SPI1 IL3 MIR221 FOSB CXCR4 ITGB3 KCNH2 VAV1 CSF2 CSF1 GATA2 IKZF1 CD34 IL1A IL6 NFATC2 HES6 IL1B ATR SIGNALING%WIKIPATHWAYS_20200510%WP3875%HOMO SAPIENS ATR Signaling RAD9B RAD1 ATRIP ATR TOPBP1 RAD9A CHEK1 HUS1 RPA1 INTRAFLAGELLAR TRANSPORT PROTEINS BINDING TO DYNEIN%WIKIPATHWAYS_20200510%WP4532%HOMO SAPIENS Intraflagellar transport proteins binding to dynein DYNLT1 IFT140 DYNC1I1 DYNC1LI2 DYNC2H1 DYNLL1 WDR34 IFT80 WDR35 IFT43 IFT81 IFT46 DYNC2LI1 IFT22 TCTEX1D2 WDR19 DYNLL2 DYNLRB2 DYNLRB1 IFT122 DYNC1I2 WDR60 DYNLT3 IFT27 DYNC1H1 HSPB11 DYNC1LI1 SELECTIVE EXPRESSION OF CHEMOKINE RECEPTORS DURING T-CELL POLARIZATION%WIKIPATHWAYS_20200510%WP4494%HOMO SAPIENS Selective expression of chemokine receptors during T-cell polarization TGFB1 TGFB3 IL12B IL12RB1 IL2 IL12RB2 IL18R1 IL4R IFNGR1 IFNGR2 CXCR3 IL4 CCR1 IL12A CXCR4 CD28 CCR3 IFNG CSF2 CCR7 CCR5 CD40LG CCR4 TGFB2 CD4 IL5 CCR2 CCL4 CCL3 VITAMIN D-SENSITIVE CALCIUM SIGNALING IN DEPRESSION%WIKIPATHWAYS_20200510%WP4698%HOMO SAPIENS Vitamin D-sensitive calcium signaling in depression TPH2 GGTLC2 SLC8A1 GGTLC1 GCLC KDM1B CALB1 GGT1 ATP2B4 BCL2 GPX4 KCNQ3 GGT2 GRIN2D PVALB GGTLC3 G6PD GRIN2C CACNA1C GRIN2B ATP2B2 CYP27A1 GRM5 GRIN2A KDM1A TPH1 KDM6B KDM3A KCNQ2 VDR ITPR1 GSR ATP2B3 ITPR2 ATP2B1 GRIN1 ITPR3 CHRM1 CYP27B1 RXRA NFE2L2 EXERCISE-INDUCED CIRCADIAN REGULATION%WIKIPATHWAYS_20200510%WP410%HOMO SAPIENS Exercise-induced Circadian Regulation GSTP1 EIF4G2 CLDN5 HIST1H2BN NCOA4 CEBPB SUMO1 CRY2 CRY1 PPP2CB UGP2 KLF9 HLA-DMA HSPA8 NCKAP1 G0S2 MIR6883 TAB2 CBX3 IDI1 CLOCK NR1D2 DAZAP2 FAM47E-STBD1 BTG1 HERPUD1 SUMO3 ERC2 ZFR TOB1 GFRA1 PIGF PURA SF3A3 RBPMS ETV6 ARNTL AZIN1 QKI DNAJA1 VAPA GSTM3 MYF6 PSMA4 PER2 PER1 TUBB3 UCP3 PPP1R3C TCA CYCLE (AKA KREBS OR CITRIC ACID CYCLE)%WIKIPATHWAYS_20200510%WP78%HOMO SAPIENS TCA Cycle (aka Krebs or citric acid cycle) SDHC SDHD SDHB SDHA CS IDH3A DLD OGDH ACO2 FH IDH2 SUCLA2 DLST SUCLG2 SUCLG1 IDH3G IDH3B MDH2 ONE CARBON METABOLISM AND RELATED PATHWAYS%WIKIPATHWAYS_20200510%WP3940%HOMO SAPIENS One carbon metabolism and related pathways AGXT2 CHKB GPX4 GNMT DNM1 MAT2A BHMT2 MTR MAT1A CSAD CDO1 BCAT1 GPX1 AHCYL1 GPX3 GSR DHFRL1 SOD2 SOD3 SHMT2 SOD1 SHMT1 CBS PCYT1B PCYT1A PCYT2 MIR6778 CHKA ETNK2 BHMT ETNK1 SARDH PEMT GCLC CHPT1 CEPT1 GSS CTH PLD1 GCLM GPX2 BAAT DNMT3A TYMS CHDH GAD1 MTHFR GAD2 GPX6 DMGDH GPX5 GPX7 BCAT2 PROTEOGLYCAN BIOSYNTHESIS%WIKIPATHWAYS_20200510%WP4784%HOMO SAPIENS Proteoglycan biosynthesis EXT1 SLC26A2 CSGALNACT1 SLC35B3 XYLT1 SLC35B2 CANT1 B3GAT3 XYLT2 B3GALT6 EXT2 CHSY1 IMPAD1 MIR4647 CHST14 B4GALT7 EXTL3 CHST3 PAPSS2 OMEGA-9 FA SYNTHESIS%WIKIPATHWAYS_20200510%WP4724%HOMO SAPIENS Omega-9 FA synthesis ACSL3 MIR1908 ELOVL1 SCD5 ELOVL6 MIR6734 FADS2 SCD FASN ACOT2 FADS1 ELOVL5 ACSL1 ELOVL2 ELOVL3 ACSL4 OSTEOBLAST DIFFERENTIATION%WIKIPATHWAYS_20200510%WP4787%HOMO SAPIENS Osteoblast differentiation FZD6 FZD9 FZD8 NOTCH2 WNT2B NOTCH3 FGF1 NOTCH1 FGF3 FGF4 NOTCH4 FGF5 FGF6 FGF7 FGF9 WNT16 DLL1 LRP5 DLL3 DLL4 PIK3CD LRP6 SMAD1 MAPK9 JAG2 MAPK8 WNT11 JAG1 MAPK1 WNT7B FGF2 WNT7A MAPK12 CTNNB1 MAPK13 MAPK10 MAPK11 BMPR1A GLI3 FGF18 GLI2 PIK3C2B FGFR3 FGFR2 FGF10 FGFR1 PRKCE PRKDC PRKD1 SMAD9 WNT8A SMAD5 PIK3R3 FZD4 BMP4 WNT9B PIK3R2 BMPR2 PIK3R1 PIK3CB BMPR1B PIK3CA STAT1 IHH SOX9 PIK3R5 BMP2 PRKCH PTCH1 PRKCZ MAPK3 WNT9A RUNX2 PIK3R6 SMO WNT8B PPARG PRKCG PRKCB PRKCA PIK3C2G PIK3C2A PIK3CG PRKCI HES3 PRKCD HES2 PRKCQ MAPK7 MAPK6 PIK3R4 FGFR4 MAPK4 PIK3C3 FZD10 MYOD1 WNT5B WNT5A HEY1 WNT6 SMAD4 WNT1 WNT2 MIR4683 MAPK14 WNT3 WNT4 RBPJ FZD1 HEY2 FGF8 WNT10B FZD3 WNT10A FZD2 FZD5 WNT3A HES6 FZD7 THIAMINE METABOLIC PATHWAYS%WIKIPATHWAYS_20200510%WP4297%HOMO SAPIENS Thiamine metabolic pathways TPK1 SLC25A19 SLC19A3 TKT PDHA1 OGDH SLC19A2 BCKDHA BCKDK MAPK CASCADE%WIKIPATHWAYS_20200510%WP422%HOMO SAPIENS MAPK Cascade MAP2K6 MAP2K7 ARAF LAMTOR3 MAP3K12 SOS2 NRAS ELK1 MAPK1 HRAS MAP2K1 MAP2K2 MAPK12 MAP2K3 MAPK10 MAP2K4 RRAS MAP3K1 KRAS BRAF GRB2 SOS1 RAF1 MAPK14 MAP2 RASA3 JUN PLCB3 SIPA1 MAPK3 MBP MAP3K2 MAP3K3 SARS CORONAVIRUS AND INNATE IMMUNITY%WIKIPATHWAYS_20200510%WP4912%HOMO SAPIENS SARS coronavirus and innate immunity IRF3 TRAF3 MAVS ACE2 IFNA21 TYK2 TICAM1 IFNA5 IFNA4 IFNA7 TLR3 IFNA6 IFNA1 IFNA2 IFNA8 STAT1 IFNB1 TBK1 IKBKE IFNAR2 STAT2 IRF9 IFNAR1 IFIH1 IFNA13 IFNA14 IFNA16 IFNA17 DDX58 JAK1 IFNA10 MIRNA TARGETS IN ECM AND MEMBRANE RECEPTORS%WIKIPATHWAYS_20200510%WP2911%HOMO SAPIENS miRNA targets in ECM and membrane receptors MIR532 MIR219A1 MIR548AA1 MIR548D1 MIR429 ITGB6 MIR25 THBS1 COL1A2 ITGA11 COL6A2 COL6A1 TNXB MIR148B COL6A3 MIR15B MIR141 ITGA1 FN1 LAMB2 LAMA4 COL5A3 THBS2 COL5A2 COL3A1 COL5A1 COL4A1 LAMC1 ITGB5 MIR589 MIR30D COL4A2 MIR30B SDC2 MIR30C1 MIR107 IMATINIB AND CHRONIC MYELOID LEUKEMIA%WIKIPATHWAYS_20200510%WP3640%HOMO SAPIENS Imatinib and Chronic Myeloid Leukemia NOP2 BCR SPRED2 MIR1204 ABCG2 GADD45A SKP2 GAB2 MYC CDKN1B ABCB1 PIM1 ABL1 FOXO3 KIT PIM2 PDGFRB PDGFRA CSF1R FLT1 LYL1 CANONICAL NF-KB PATHWAY%WIKIPATHWAYS_20200510%WP4562%HOMO SAPIENS Canonical NF-KB pathway NFKBIE RELA NFKB1 IKBKB NFKBIA REL CHUK IKBKG MIRNA REGULATION OF P53 PATHWAY IN PROSTATE CANCER%WIKIPATHWAYS_20200510%WP3982%HOMO SAPIENS miRNA regulation of p53 pathway in prostate cancer SERPINE1 CASP9 SIAH1 MDM2 CASP8 CHEK2 ATM PERP CASP3 MIR3191 MIR548C TP53AIP1 MIR3190 ZMAT3 MIR4482 PMAIP1 MIR4491 SHISA5 CYS1 DDB2 EI24 TNFRSF10B MIR548B MIR1305 TP53 PTEN MIR320A MIR182 BID BBC3 SESN3 BAX APAF1 GDNF/RET SIGNALLING AXIS%WIKIPATHWAYS_20200510%WP4830%HOMO SAPIENS GDNF/RET signalling axis AGTR2 SLIT2 EYA1 LHX1 CTNNB1 PAX2 IFT27 GDNF SOX17 HSPB11 SPRY1 GATA3 FOXC2 GLI3 BMP4 FOXC1 RET ROBO2 SOX11 GREM1 SALL1 FAT4 GFRA1 UREA CYCLE AND RELATED DISEASES%WIKIPATHWAYS_20200510%WP4571%HOMO SAPIENS Urea cycle and related diseases GLS2 SLC25A15 SLC25A13 OTC ASS1 CPS1 ASL NAGS ARG1 NUCLEOTIDE METABOLISM%WIKIPATHWAYS_20200510%WP404%HOMO SAPIENS Nucleotide Metabolism PRPS2 OAZ1 POLB NME1-NME2 POLG SAT1 PRPS1 ADSL SRM DHFR RRM2B POLD1 IMPDH1 MTHFD2 HPRT1 RRM1 ADSS RRM2 POLA1 ROLE OF ALTERED GLYCOLYSATION OF MUC1 IN TUMOUR MICROENVIRONMENT%WIKIPATHWAYS_20200510%WP4480%HOMO SAPIENS Role of Altered Glycolysation of MUC1 in Tumour Microenvironment TNF RELA MUC1 NFKB1 IKBKB NFKBIA IL6 CHUK IKBKG PHASE I BIOTRANSFORMATIONS, NON P450%WIKIPATHWAYS_20200510%WP136%HOMO SAPIENS Phase I biotransformations, non P450 CES5A CES2 CES1 PON3 PON2 PON1 ESD LIPA METABOLISM OF DICHLOROETHYLENE BY CYP450%WIKIPATHWAYS_20200510%WP3666%HOMO SAPIENS Metabolism of Dichloroethylene by CYP450 CYP2E1 ENVELOPE PROTEINS AND THEIR POTENTIAL ROLES IN EDMD PHYSIOPATHOLOGY%WIKIPATHWAYS_20200510%WP4535%HOMO SAPIENS Envelope proteins and their potential roles in EDMD physiopathology TGFB1 TGFB3 ADCY4 ADCY3 LBR YY1AP1 ADCY7 ADCY6 ADCY5 ADCY9 SOS2 SMAD2 SRF ADCY1 ADCY8 SYNE2 NRAS MAPK1 KIF5B HRAS MAP2K1 MAP2K2 MAP3K9 ADCY10 SMAD4 KRAS SMAD3 RHOA GRB2 CTGF TGFB2 SOS1 SYNE4 SYNE3 SYNE1 TMEM43 TAZ BANF1 EMD TMPO SUN1 PLEC MAPK3 LEMD3 CFL1 ADCY2 WNT SIGNALING PATHWAY AND PLURIPOTENCY%WIKIPATHWAYS_20200510%WP399%HOMO SAPIENS Wnt Signaling Pathway and Pluripotency FZD6 FZD9 CTNND1 FZD8 ZBTB33 FOSL1 FBXW2 ESRRB PPM1J GSK3B WNT2B AXIN1 AXIN2 WNT16 LEF1 LRP5 NKD1 PPP2R2A NKD2 LRP6 MAPK9 CREBBP WNT11 PPP2CB TCF7L2 TCF7L1 PPP2R1B MIR1281 PPP2R5E WNT7B PPP2R1A WNT7A MIR6808 RACGAP1 APC CTNNB1 MAPK10 NANOG PPP2R3B PPP2R3A PPP2R5C PPP2R2C PPP2R2B LRRK2 PRKCE PRKD1 POU5F1 MMP7 FOXD3 CD44 FZD4 WNT9B PPP2CA MAP2K4 PRKCH PRKCZ CCND1 PPARD PRKCG PRKCB PRKCA TP53 NFYA PRKCI PRKCD RHOA PRKCQ MIR6886 LDLR FZD10 CCND3 FRAT1 CCND2 PLAU MYC MAP3K7 WNT5B WNT5A CSNK1E PAFAH1B1 PPP2R4 CTBP2 CTBP1 TCF7 NLK WNT6 DVL1 DVL2 DVL3 WNT1 WNT2 MIR4683 WNT3 WNT4 FZD1 WNT10B EP300 JUN SOX2 FZD3 WNT10A FZD2 FZD5 WNT3A FZD7 MAPK AND NFKB SIGNALLING PATHWAYS INHIBITED BY YERSINIA YOPJ%WIKIPATHWAYS_20200510%WP3849%HOMO SAPIENS MAPK and NFkB Signalling Pathways Inhibited by Yersinia YopJ MAP2K6 TRAF6 MAPK1 RAF1 NFKB1 IKBKB NFKBIA MAP3K1 RRAS MAP3K14 CHUK IKBKG NAD BIOSYNTHESIS II (FROM TRYPTOPHAN)%WIKIPATHWAYS_20200510%WP2485%HOMO SAPIENS NAD Biosynthesis II (from tryptophan) TDO2 KYNU AFMID QPRT KMO NADSYN1 HAAO NMNAT1 HEREDITARY LEIOMYOMATOSIS AND RENAL CELL CARCINOMA PATHWAY%WIKIPATHWAYS_20200510%WP4206%HOMO SAPIENS Hereditary leiomyomatosis and renal cell carcinoma pathway RPS6 HIF1A ACACB VEGFA EGLN1 PRKAG1 KEAP1 PDHB PDK1 CUL3 PRKAA1 SLC11A2 SLC2A1 TP53 ACACA PRKAB1 PDHA1 PDHA2 NFE2L2 LDHA MITOCHONDRIAL CIII ASSEMBLY%WIKIPATHWAYS_20200510%WP4921%HOMO SAPIENS Mitochondrial CIII assembly CYC1 UQCRC1 UQCRC2 UQCRB UQCC3 UQCC1 UQCRH UQCC2 BCS1L UQCRQ TTC19 MT-CYB LYRM7 UQCRFS1 UQCR11 UQCR10 PEROXIREDOXIN 2 INDUCED OVARIAN FAILURE%WIKIPATHWAYS_20200510%WP4873%HOMO SAPIENS Peroxiredoxin 2 induced ovarian failure HSD3B2 BAX CASP3 MAPK10 STAR PRDX2 CYP11A1 PARP2 KIT RECEPTOR SIGNALING PATHWAY%WIKIPATHWAYS_20200510%WP304%HOMO SAPIENS Kit receptor signaling pathway RPS6 GRB7 MAPT AKT1 GAB2 PRKCB PRKCA INPP5D MATK SRC SNAI2 DOK1 KIT FOXO3 SOCS6 BTK MAPK8 MAPK1 HRAS MAP2K1 KITLG MIR1281 MAP2K2 PLCG1 STAT5A STAT5B JUNB BAD CRK GRB2 SOS1 RAF1 CBL FOS MITF SH2B2 RPS6KB1 TBX2 BCL2 FYN PTPN11 PIK3R2 PIK3R1 LYN STAT1 RPS6KA3 PTPN6 RPS6KA1 TEC GRB10 VAV1 SNAI1 CRKL MAPK14 SHC1 EP300 STAT3 JAK2 MAPK3 SOCS1 HEME BIOSYNTHESIS%WIKIPATHWAYS_20200510%WP561%HOMO SAPIENS Heme Biosynthesis FECH UROD UROS HMBS ALAS1 CPOX PPOX ALAD ALAS2 CHOLESTEROL BIOSYNTHESIS WITH SKELETAL DYSPLASIAS%WIKIPATHWAYS_20200510%WP4804%HOMO SAPIENS Cholesterol Biosynthesis with Skeletal Dysplasias EBP NSDHL SC5D CYP51A1 DHCR7 LBR DHCR24 CORI CYCLE%WIKIPATHWAYS_20200510%WP1946%HOMO SAPIENS Cori Cycle TPI1 SLC2A2 PGK1 PFKP ALDOA GAPDH HK1 INS PGAM1 SLC2A4 TALDO1 G6PD SLC2A1 GPT PGK2 GPI LDHA CONTROL OF IMMUNE TOLERANCE BY VASOACTIVE INTESTINAL PEPTIDE%WIKIPATHWAYS_20200510%WP4484%HOMO SAPIENS Control of immune tolerance by vasoactive intestinal peptide TGFB1 IL2 IFNG IL10 FAS IL5 CD86 VIP CD80 IL4 IL12A CD28 CTLA4 EXTRACELLULAR VESICLE-MEDIATED SIGNALING IN RECIPIENT CELLS%WIKIPATHWAYS_20200510%WP2870%HOMO SAPIENS Extracellular vesicle-mediated signaling in recipient cells TGFB1 TGFB3 MFGE8 TGFBR3 AKT1 TGFBR1 PROM1 TGFBR2 AXIN1 TGFA SMAD2 WNT5A EGFR ERBB2 NRAS DKK4 HRAS PIK3R5 APC CTNNB1 SMAD4 KRAS SMAD3 TSPAN8 TGFB2 RAF1 HGF MTOR WNT3A MET MIRNA REGULATION OF DNA DAMAGE RESPONSE%WIKIPATHWAYS_20200510%WP1530%HOMO SAPIENS miRNA Regulation of DNA Damage Response RB1 CDKN1A CDK1 CASP9 PIDD1 CASP8 CCNB1 CCND1 CHEK2 CHEK1 CASP3 TLK1 FAS NBN H2AFX MRE11A CDC25C DDB2 CDC25A RAD50 RRM2B RAD51 FANCD2 TP53 RAD9A MIR16-1 E2F1 CCNG1 BID PML GADD45B GADD45A GADD45G CDK6 MCM7 BBC3 CDK4 HUS1B BAX TLK2 CYCS CDC20B ATRIP CDKN1B CCNE2 BRCA1 APAF1 CCNE1 RAD52 MIR203A CDK5 CDK2 PRKDC RAD17 MIR106B MDM2 RAD1 ATR MIR181A1 ATM CCND3 MIR449B MIR449A MIR3191 TP53AIP1 CCND2 MIR3190 MIR222 PMAIP1 MIR145 MYC MIR221 TNFRSF10B MIR20A MIR17 MIR373 MIR19B1 MIR19A MIR92A1 MIR17HG SMC1A MIR210 CREB1 CCNB3 CCNB2 ABL1 SFN SESN1 RFC1 RPA2 ENDOCHONDRAL OSSIFICATION%WIKIPATHWAYS_20200510%WP474%HOMO SAPIENS Endochondral Ossification PLAT SERPINH1 AKT1 ADAMTS5 COL2A1 ALPL ACAN CAB39 MMP13 PTH BMP7 MMP9 FGF2 TIMP3 STAT5B BMPR1A TGFB2 CTSV GLI3 ADAMTS4 ADAMTS1 FGF18 COL10A1 NKX3-2 SOX5 DDR2 FGFR3 CST5 SCIN FRZB FGFR1 SLC38A2 TGFB1 MIR6073 MGP RUNX3 SOX6 IFT88 GH1 PLAU IGF2 PTHLH HMGCS1 PTH1R GHR MEF2C IGF1R STAT1 THRA SPP1 IHH SOX9 IGF1 VEGFA ENPP1 CDKN1C BMP6 PRKACA HDAC4 PTCH1 CALM3 CALM1 CHST11 CALM2 RUNX2 KIF3A CAFFEINE AND THEOBROMINE METABOLISM%WIKIPATHWAYS_20200510%WP3633%HOMO SAPIENS Caffeine and Theobromine metabolism CYP1A2 XDH NAT2 CYP2A6 INHIBITION OF EXOSOME BIOGENESIS AND SECRETION BY MANUMYCIN A IN CRPC CELLS%WIKIPATHWAYS_20200510%WP4301%HOMO SAPIENS Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells MAPK1 HRAS ARAF RRAS KRAS BRAF RAF1 RAB5B RRAS2 PDCD6IP RAB5C RAB27A MAPK3 HGS RAB5A MRAS NRAS HNRNPH1 ZINC HOMEOSTASIS%WIKIPATHWAYS_20200510%WP3529%HOMO SAPIENS Zinc homeostasis SLC39A12 MT1L MT1M SLC30A10 MT2A SLC30A7 SLC30A6 SLC30A9 SLC30A8 SLC30A3 SLC39A9 SLC30A2 SLC39A6 SLC30A5 SLC39A5 SLC30A4 SLC39A8 SLC39A7 SLC30A1 SLC39A2 MT4 SLC39A1 MT3 SLC39A4 MT1A SLC39A3 MTF1 MT1F SLC39A14 MT1G MT1H MT1B MT1E MT1X SLC39A11 SLC39A10 SLC39A13 APOPTOSIS MODULATION BY HSP70%WIKIPATHWAYS_20200510%WP384%HOMO SAPIENS Apoptosis Modulation by HSP70 FASLG CASP9 BID CASP8 CASP2 CASP3 MAPK10 FAS RIPK1 MAP3K1 TNFRSF1A HSPA1A AIFM1 FADD CASP7 CASP6 CYCS NFKB1 APAF1 PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9 (PCSK9) MEDIATED LDL RECEPTOR DEGRADATION%WIKIPATHWAYS_20200510%WP2846%HOMO SAPIENS Proprotein convertase subtilisin/kexin type 9 (PCSK9) mediated LDL receptor degradation MIR6886 LDLR PCSK9 AUTOSOMAL RECESSIVE OSTEOPETROSIS PATHWAYS%WIKIPATHWAYS_20200510%WP4788%HOMO SAPIENS Autosomal recessive Osteopetrosis pathways SNX10 TRAF6 TNFRSF11A RAB7A NFKB1 IKBKB TNFSF11 CLCN7 TCIRG1 OSTM1 PLEKHM1 PROLACTIN SIGNALING PATHWAY%WIKIPATHWAYS_20200510%WP2037%HOMO SAPIENS Prolactin Signaling Pathway RPS6 EIF4EBP1 AGAP2 SOCS2 FLNA GSK3B CASP3 AKT1 GAB2 YWHAZ ITGB1 PPIB PIK3CG SRC PIAS3 PXN YWHAG MAPK9 MAPK8 ERBB2 RAC1 ELK1 ZAP70 MAPK1 HRAS MAP2K1 MAP2K2 STAT5A PTK2 STAT5B GRB2 SOS1 RAF1 CBL FOS PRLR PRL MTOR PTPN1 IRF1 RPS6KB1 SIRPA NOS2 MYC FYN IRS1 NFKBIB PTPN11 PIK3R2 IRS2 PIK3R1 PIK3CB PIK3CA STAT1 PTPN6 RPS6KA2 TEC VAV1 VAV2 MAPK14 NEK3 CTSD RELA PPIA SHC1 NFKB1 JUN NFKBIA STAT3 JAK2 MAPK3 JAK1 PAK1 SOCS3 SOCS1 CISH ACE INHIBITOR PATHWAY%WIKIPATHWAYS_20200510%WP554%HOMO SAPIENS ACE Inhibitor Pathway ATP6AP2 AGTR2 TGFB1 NOS3 ACE2 MAS1 ACE BDKRB2 CMA1 CTSG BDKRB1 KNG1 AGT NR3C2 CYP11B2 AGTR1 REN GENES INVOLVED IN MALE INFERTILITY%WIKIPATHWAYS_20200510%WP4673%HOMO SAPIENS Genes involved in male infertility APOB ESR1 HIST1H4A AGO2 ERCC1 FAS LTF ETV5 CCNA1 ERCC2 CREBBP NOS3 MTR POLB MIR1281 MMP9 DAZL MSH5 SHMT1 BRCA2 XRCC5 SOX5 CLOCK PSAT1 FASLG MIR6778 MDM2 ATM SIRPA THBS1 CLU BCL2 NOS2 MIR6843 NOS1 AHRR MLH1 MTRR FOLH1 XRCC3 TCN2 ARNTL AR CCNT1 AHR ABCB1 ESR2 UBE2B CCNK PRDM9 CCNT2 SIRPG EPSTI1 CDK9 SLC16A7 MIR3960 MIR4467 EPPIN RAG1 NANOS1 INSR USP8 VCX3A PRM2 PRM1 PRM3 SPATA17 MSH4 CYP17A1 TSSK6 TSSK4 MAS1L DDX4 MIR5090 DAZ4 DAZ3 RGS9 VCX XRCC4 UBR2 LIG4 DAZ2 SLC46A1 DAZ1 KLK2 STRA8 UBD MOV10L1 TMEM132E XRCC2 HMGA1 TAS2R38 PUM2 PIWIL2 CRISP2 PIWIL1 PIWIL4 PIWIL3 SPO11 YBX2 HORMAD2 HORMAD1 MSMB PARP1 PRMT6 PACRG CCDC36 KDM3A NQO1 GPX1 TEX15 H2BFWT DDX20 CXXC1 ABLIM1 HLA-DRA OR2W3 PMS2 SOD2 USP26 SOD3 MTHFD1 SEPT12 PEX10 CAT LRWD1 CYP1A1 CDC42BPA MLH3 REC8 CTCFL HIST3H3 NFE2L2 SEMG1 TRIP13 BRDT GNAO1 BHMT SRD5A2 PEMT CHD2 MIR3175 POLG MMP2 PON2 PON1 MTHFR XPC TNF CYP26B1 EP300 DND1 RFC1 GLOBO SPHINGOLIPID METABOLISM%WIKIPATHWAYS_20200510%WP1424%HOMO SAPIENS Globo Sphingolipid Metabolism ST8SIA1 ST6GALNAC1 ST6GAL1 FUT1 ST6GAL2 ABO ST6GALNAC2 GALNT2 GCNT1 B3GALT5 FUT2 ST3GAL1 GBGT1 ST3GAL2 FUT9 ST6GALNAC6 A4GALT ST6GALNAC4 ST6GALNAC5 B3GALNT1 ST6GALNAC3 LEPTIN INSULIN OVERLAP%WIKIPATHWAYS_20200510%WP3935%HOMO SAPIENS Leptin Insulin Overlap PDPK1 SOCS2 INSR LEP AKT1 INS DGKZ IRS1 PIK3R3 IRS4 PIK3CG IRS2 STAT3 JAK2 SOCS3 LEPR SOCS1 METHIONINE DE NOVO AND SALVAGE PATHWAY%WIKIPATHWAYS_20200510%WP3580%HOMO SAPIENS Methionine De Novo and Salvage Pathway MSRA IL4I1 TXN MTAP MSRB2 MTR ADI1 CHDH MSRB3 MAT1A ENOPH1 BHMT SMS TAT ODC1 MAT2B SRM MAT2A AMD1 AHCY APIP MRI1 DEREGULATION OF RAB AND RAB EFFECTOR GENES IN BLADDER CANCER%WIKIPATHWAYS_20200510%WP2291%HOMO SAPIENS Deregulation of Rab and Rab Effector Genes in Bladder Cancer RPH3AL SYTL1 GCC2 RAB27B MYRIP SYTL5 SYTL4 SYTL3 UNC13D SYTL2 MLPH TBC1D10A MADD EXPH5 RPH3A RAB27A SYNAPTIC SIGNALING PATHWAYS ASSOCIATED WITH AUTISM SPECTRUM DISORDER%WIKIPATHWAYS_20200510%WP4539%HOMO SAPIENS Synaptic signaling pathways associated with autism spectrum disorder EIF4EBP1 DLG4 AKT2 GSK3B RHEB PRKAG1 AKT1 PRKAG2 PRKAG3 RPTOR CAMK2B GRIN2D ARC PRKAB2 PRKAB1 PIK3CD SYNGAP1 NRAS HOMER1 AKT3 GRIN2C CACNA1C MAPK1 GRIN2B HRAS MIR5004 KRAS PRKAA1 BDNF PRKAA2 MTOR RPS6KB1 NF1 GRIN3B GRIN3A PIK3R3 PIK3R2 PIK3R1 PTEN PIK3CB PIK3CA GRM1 NTRK2 GRIN2A TSC2 TSC1 GRIN1 UBE3A CAMK4 MAPK3 STEROID BIOSYNTHESIS%WIKIPATHWAYS_20200510%WP496%HOMO SAPIENS Steroid Biosynthesis HSD3B2 F13B HSD3B1 HSD17B7 HSD17B1 HSD17B2 HSD17B4 HSD17B3 CPN1 CYP17A1 CYTOPLASMIC RIBOSOMAL PROTEINS%WIKIPATHWAYS_20200510%WP477%HOMO SAPIENS Cytoplasmic Ribosomal Proteins RPS6 RPL28 RPL10 RPL12 MRPL19 RPL36A RPS4Y1 RPS15A RPL11 RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL41 RPL35A RPL23A RPL3L RPS26 RPS25 RPS28 RPS29 RPL27A RPS20 FAU RPS21 MIR6850 RPS24 RPS23 RPS27 UBA52 RPS6KB1 RPS6KB2 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPL34 RPLP1 RPLP0 RPL10A RPL8 RPL9 RPL6 RPL7 RPS4X RPS15 RPS6KA3 RPS14 RPS6KA6 RPL7A RPS17 RPS16 MIR6805 RPS6KA2 RPL18A RPS6KA1 RPS19 RPS18 RPS27A RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPL39 RPS10 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPL13A RPS3A RPSA RPL37A RPL24 RPL27 RPL26 RPL29 LUNG FIBROSIS%WIKIPATHWAYS_20200510%WP3624%HOMO SAPIENS Lung fibrosis CYSLTR2 CXCL2 IL12B CMA1 IL13 FGF1 CEBPB FGF7 IL4 TGFA CXCL8 BMP7 MECP2 PDGFB MMP9 FGF2 CSF3 SFTPA2 HMOX1 EGF IL5 HGF NFE2L2 TGFB1 MT2A SKIL PLAU TERT SMAD7 SFTPC CALCA GREM1 SPP1 IGF1 MMP2 CCL2 TIMP1 EDN1 CCR3 CCL11 PDGFA CSF2 ELN FAM13A CTGF OBFC1 ELMOD2 CCL5 SERPINA1 CCR2 ATP11A RTEL1 CCL4 PARN CCL3 DPP9 TNF MUC5B PTX3 SFTPA1 DSP IL6 IL1B IL-5 SIGNALING PATHWAY%WIKIPATHWAYS_20200510%WP127%HOMO SAPIENS IL-5 Signaling Pathway RPS6 RPS6KB1 RPS6KB2 IL2 GSK3B MAPT AKT1 BCL2 MYC GSK3A PTPN11 PIK3R2 PIK3CG SYK PIK3R1 FOXO3 LYN BTK IL5RA STAT1 CSF2RB ELK1 MAPK1 MAP2K1 RPS6KA1 MAP2K2 STAT5A STAT5B SPRED1 KRAS GRB2 SOS1 RAF1 FOS SHC1 JUN STAT3 JAK2 MAPK3 JAK1 SYNAPTIC VESICLE PATHWAY%WIKIPATHWAYS_20200510%WP2267%HOMO SAPIENS Synaptic Vesicle Pathway RIMS1 DNM1L SLC18A1 SLC18A3 UNC13B UNC13C SLC38A1 UNC13A SYP CLTC SYN3 SYN2 CLTA DNM3 AP2A1 PARK7 STX1B NAPA SNAP25 SLC22A3 SLC25A4 ATP1A2 CPLX2 DNM1 CLN8 CPLX1 DNM2 CPLX3 SLC17A6 SLC17A7 SLC17A8 STX3 AP2S1 SYT1 AP2B1 CACNA1B CLTCL1 STX1A STX2 VAMP2 SLC18A2 RAB3A NSF SYN1 SLC6A4 CACNA1A AP2A2 SLC1A3 SLC32A1 STXBP1 AP2M1 NICOTINE ACTIVITY ON CHROMAFFIN CELLS%WIKIPATHWAYS_20200510%WP1603%HOMO SAPIENS Nicotine Activity on Chromaffin Cells CACNA1C CHRNB4 CACNA1G CHRNA3 BMP SIGNALING PATHWAY IN EYELID DEVELOPMENT%WIKIPATHWAYS_20200510%WP3927%HOMO SAPIENS BMP Signaling Pathway in Eyelid Development SFRP1 SMAD4 MAP3K1 NOTCH1 SMAD5 INHBB SHH FOXC2 BMP4 FOXC1 JUN TGFA MAPK3 EGFR SMAD1 MAPK9 FGFR2 DKK2 FGF10 PITX2 IRON METABOLISM IN PLACENTA%WIKIPATHWAYS_20200510%WP2007%HOMO SAPIENS Iron metabolism in placenta STEAP3 SLC11A2 TFRC SLC40A1 TF ACO1 HEPHL1 HAMP TFR2 IREB2 MCOLN1 FTH1 MIR-222 IN EXERCISE-INDUCED CARDIAC GROWTH%WIKIPATHWAYS_20200510%WP3938%HOMO SAPIENS miR-222 in Exercise-Induced Cardiac Growth HIPK1 HIPK2 CDKN1B HMBOX1 RETINOBLASTOMA GENE IN CANCER%WIKIPATHWAYS_20200510%WP2446%HOMO SAPIENS Retinoblastoma Gene in Cancer RB1 TFDP2 CDKN1A TTK CDK1 SAP30 CCNB1 CCND1 CHEK1 RPA3 POLE2 HDAC1 CDC25A PLK4 SIN3A CDC25B TP53 E2F1 CDC45 E2F2 E2F3 MAPK13 SUV39H1 RBBP4 SMARCA2 CDK6 MCM7 RAF1 CDK4 PRIM1 RBBP7 DHFR CDKN1B CCNE2 BARD1 ORC1 CDT1 RRM1 MSH6 RRM2 CDC7 CCNE1 POLA1 WEE1 ANLN MCM3 MCM4 CDK2 PRKDC SMC2 MCM6 MDM2 PRMT2 DCK RBP1 NPAT HLTF CCND3 FANCG SMC3 RABIF KIF4A CCDC6 ZNF655 MYC TOP2A HMGB2 H2AFZ FAF1 DNMT1 STMN1 TYMS CCNA2 MIR3917 SKP2 SMC1A PCNA POLD3 HMGB1 POLE RFC5 RFC3 CCNB2 ABL1 RFC4 RPA1 TFDP1 RPA2 PREIMPLANTATION EMBRYO%WIKIPATHWAYS_20200510%WP3527%HOMO SAPIENS Preimplantation Embryo EGR1 H2AFY2 TFAP2B MXD1 TEAD4 GATA3 SIX3 NKX2-1 SOX8 E2F5 HMGA1 TCF7L1 PBX1 NANOG CDX2 DNMT3L SMARCA4 ZFP36L2 ELAVL1 ATP1A1 MTA3 MIR302A ZFP42 POU5F1 MOS FOSB SOX11 NANOGNB CELF3 AQP9 AQP3 KHSRP IRF4 ZAR1 ARGFX DPPA3 PADI6 BARX2 FOXD1 LEUTX NLRP5 IRX5 MYBL1 TPRX1 HNRNPAB ZFP36 DDIT3 TBX3 DLX2 DPRX BATF3 MIR3940 ZSCAN4 GATA2 FOXQ1 ESRRA SOX2 NR3C2 CDH1 KLF4 MITOCHONDRIAL CIV ASSEMBLY%WIKIPATHWAYS_20200510%WP4922%HOMO SAPIENS Mitochondrial CIV Assembly COX19 COX16 TACO1 COX18 COX6B1 HIGD1A PET117 COX14 COX10 MT-CO3 COA6 COA3 COX15 PET100 COX17 CMC1 COX7A2 TMEM177 PNKD SCO2 MT-CO1 COX11 SMIM20 COX20 COX7B COX4I1 COX7C COX8A SURF1 COX5B COX5A NDUFA4 MT-CO2 COX6C COX6A1 HIPK2 IN KIDNEY FIBROSIS%WIKIPATHWAYS_20200510%WP4751%HOMO SAPIENS HIPK2 in kidney fibrosis HIPK2 SIAH1 HEPATITIS C AND HEPATOCELLULAR CARCINOMA%WIKIPATHWAYS_20200510%WP3646%HOMO SAPIENS Hepatitis C and Hepatocellular Carcinoma CDKN1A CTTN CASP9 CCND1 CASP3 AKT1 CXCR1 HNF1A TP53 LEF1 MMP1 CXCL8 MAPK8 RAC1 E2F2 MIR744 IL6R GRB2 PODXL SOS1 CASP7 BCL2L1 BRCA1 COL4A2 RRM2 FRZB FASLG TGFB1 PTGS2 BIRC3 TGFBR1 NOS2 CD44 MYC MYOF PTPN11 HIF1A VEGFA UCHL1 VAV2 BIRC5 SMAD4 SMAD3 MAPK14 NFKB1 JUN STAT3 MAPK3 JAK1 IL6 LIDOCAINE METABOLISM%WIKIPATHWAYS_20200510%WP2646%HOMO SAPIENS Lidocaine metabolism CYP3A4 CYP1A2 OXIDATIVE DAMAGE%WIKIPATHWAYS_20200510%WP3941%HOMO SAPIENS Oxidative Damage TRAF3 CDKN1A MIR7846 CASP9 C5AR1 CASP3 TRAF2 BCL2 CR2 TRAF6 NFKBIE C1QB C1QA C1S C1R C2 C4B CDC42 BAG4 BAK1 TDP2 TNK2 CDKN1C C1QC C3AR1 MAP3K9 MAPK13 GADD45A BAD MAPK10 MAP2K4 MAP3K1 PCNA CYCS TNF CDKN1B NFKB1 C5 APAF1 TRAF1 TNFRSF1B VITAMIN A AND CAROTENOID METABOLISM%WIKIPATHWAYS_20200510%WP716%HOMO SAPIENS Vitamin A and Carotenoid Metabolism LPL ABCG5 RBP1 CYP2E1 DGAT1 RBP4 ALDH1A2 MIR6848 RARB CRABP2 CRABP1 RXRB CD36 MAPK1 RARA SULT1A1 RXRG RETSAT ALDH1A1 RDH8 RLBP1 SDR16C5 RDH12 NPC1L1 AWAT2 RDH10 SCARB1 ADH1A LRAT BCO2 BCO1 DHRS3 ABCG8 RPE65 ALDH1A3 RARG SULT2B1 CYP26A1 ADH4 RBP7 RBP2 CYP26B1 RDH5 RXRA IL-18 SIGNALING PATHWAY%WIKIPATHWAYS_20200510%WP4754%HOMO SAPIENS IL-18 signaling pathway CD83 FBXW7 LCK GSK3B ACTA2 RPTOR CPT1A FOXN3 GRIN2B NR0B2 EEF2 ENO1 CTNNB1 COL3A1 ELAVL1 NDUFC1 MMP8 IRF6 AGPAT6 PLD1 TBX21 KIFC3 HDAC3 ZNF219 SOCS3 NFATC4 PRCC MAP2K7 BTG2 CXCL2 PRM1 LTB MMP1 PTPRZ1 MMP3 MMP13 CXCL8 NPPB NPPA KITLG PKN1 ITGA2B HMOX1 PARP1 PRKCD IL18 ARF6 PRKAA1 TMSB4X FOS IL2RA BCL2L1 SP1 NOX1 RPS6KB1 MEF2A SPON1 ZDHHC7 NR4A1 FAM110A EPS8 RUSC1 ZC3H12A LONP2 B2M IER3 IMP3 BIN1 NSMF NRN1 SDC4 ANP32A TSHZ1 MEPCE TRPM7 ZBTB7A ZNF143 STMN1 NCAPH2 MIR6732 PPT2 HOXD8 CSN2 AARS ITM2C VEGFA PIGT PHF20 MMP2 IL18BP CCNA2 PTMS IFNG KRT31 MIR3917 BAZ1B STK40 GRN TOMM40 CENPB TMEM165 CFLAR CCL18 CHUK RAE1 CA11 IL37 CCDC9 HDGF APBA2 TNF LMNB2 RELA CDK5R2 MTCH1 NFKB1 IKBKB MUM1 PLOD3 NFKBIA IL18RAP FAM186B ZNF444 TGM2 IL6 SEMA6C IL1B USP5 MIR7108 SEMA6D TRPC4AP TNFRSF11B KLC1 ACACB HCAR2 HPS1 NACA TNIP3 CNTN2 ULBP2 TNFSF11 ACADS TNFAIP2 REL RND2 WISP1 FAS IRG1 ABHD16A MBTPS1 TNFAIP3 PPP1R13L NFKBIZ LRRFIP1 COL1A2 TRPC2 BPGM CEBPB ADAMTS5 RANGAP1 ARFGAP1 ARFGAP2 ARL4D ALS2 MYH7 STOML1 PYGB MIR7114 UGGT1 ABCF1 SLC12A3 MAPK9 DEK SLC4A7 CRYGC SYT10 MAPK1 SNTB1 GATA1 MMP9 FN1 IL17RC TIMP3 COL1A1 S1PR4 NFKB2 CLDN4 CLDN1 FASLG IL18R1 BCL2 TNFRSF1A NOS2 TRAF6 PIK3R1 NR1H3 PLA2G7 ADIPOQ ICAM1 CD36 KCNH2 IRAK1 UCK1 PTPN7 BMP2 CCL2 CETP TIMP1 MIR718 RPS11 MYD88 CLDN3 MMP14 CCNB2 MAPK3 RUNX2 CLDN15 MYH6 CLDN12 CXCL3 IL12B IL9 CASP8 TICAM2 CASP3 IL10 IL13 ACTA1 PRKCB PRKCA TP53 TF UGT2B10 HADH NCF2 EPB41 RXRB ARG1 GRM7 PLCG1 FUT1 BID LARS2 BAD BAX CYCS RGS16 RASA3 KLF2 BSG TRAF1 DES ECH1 IRF1 PTGS2 COX17 BIRC3 NCF1 FADD CXCL16 MAP3K7 NFKBIE CD81 HSPB8 PTEN HSPB1 SPP1 RFX5 ATF3 CCL5 CCL4 CCL3 CCL1 CCL19 PTX3 JUN TACR1 CCL20 ESC PLURIPOTENCY PATHWAYS%WIKIPATHWAYS_20200510%WP3931%HOMO SAPIENS ESC Pluripotency Pathways MAP2K6 FZD6 FZD9 FZD8 GSK3B WNT2B FGF1 FGF3 FGF4 AXIN1 FGF5 HNF1A FGF6 FGF7 FGF9 WNT16 LRP5 PIK3CD PDGFRA EGFR LRP6 SMAD1 WNT11 AKT3 MAPK1 PDGFB HRAS MAP2K1 MAP2K2 WNT7B FGF2 WNT7A MIR6808 APC MAPK12 CTNNB1 FGF20 FGF23 FGF22 FGF21 GRB2 BMPR1A SOS1 RAF1 FGF17 FGF16 FGF14 FGF18 PDGFRB FGF13 FGFR3 FGF12 FGFR2 FGF11 FGF10 FGFR1 MDM2 NOG LIF SMAD9 SMAD6 SMAD5 SMAD7 FZD4 BMP4 WNT9B PTPN11 PIK3R2 BMPR2 BMPR1B ACVR1 ERAS STAT3 JAK1 MAP2K5 ARAF AKT2 AKT1 LIFR ELK1 IL6ST GAB1 EGF BRAF FOS MAPK7 MAPK6 FGF19 FGFR4 MAPK4 MTOR WNT5B PTEN WNT5A ACTR2 MAP2K3 PDGFA WNT6 SMAD4 DVL1 DVL2 DVL3 WNT1 WNT2 MIR4683 WNT3 WNT4 SEPP1 FZD1 FGF8 WNT10B JUN FZD3 WNT10A FZD2 FZD5 WNT3A FZD7 TOLL-LIKE RECEPTOR SIGNALING RELATED TO MYD88%WIKIPATHWAYS_20200510%WP3858%HOMO SAPIENS Toll-like Receptor Signaling related to MyD88 IRF3 RELB TRAF3 IRF7 TLR5 REL TICAM2 IRAK4 TICAM1 TIRAP TLR3 TRAF6 TLR8 MAPK1 TBK1 IRAK1 IKBKE MIR718 TOLLIP TLR7 TLR1 TLR9 MYD88 TLR2 CHUK TLR6 TLR4 NFKB2 RELA NFKB1 IKBKB IKBKG MONOAMINE TRANSPORT%WIKIPATHWAYS_20200510%WP727%HOMO SAPIENS Monoamine Transport TNFRSF11B TH TPH2 UNC13B TGFB1I1 DBH SLC6A1 CDC25C SYN1 NOS1 SLC6A4 TDO2 SCAMP2 RBL2 SLC5A7 ADORA2A ITGB3 PPP2CB IL1R1 STX1A SLC6A3 FBXO32 TSC2 MAPK14 SLC6A2 TNF AGT AMPH ACHE HRH3 PVRL2 IL1B VEGFA-VEGFR2 SIGNALING PATHWAY%WIKIPATHWAYS_20200510%WP3888%HOMO SAPIENS VEGFA-VEGFR2 Signaling Pathway CTNND1 EIF4G1 GSK3B CLTC AP2A1 DOK1 AP2S1 LDHA PGK1 ALDOA GAPDH MLST8 CTNNB1 AKT1S1 HGS AKAP2 TXN PRDX6 ACKR3 SLC2A14 EPHA2 ADRB2 CYR61 TNXB CXCL8 ARRB2 ELK1 GJA1 MAP3K5 PBK HSP90AA1 PRKCI PRKCD ATF2 RHOA DPM1 ERN1 SMARCA2 TMSB4X ERG PTK2B PGF BCL2L1 PRKAA2 ACACA HDAC5 ATF4 NR4A2 NR4A1 ITGB3 ITGAV TUBB8 VEGFA TUBA1C TPM3 MMP2 HBEGF PSMD4 MAP2K3 NFATC1 MAPK14 RELA HMGB1 NFKB1 TFAM PSMD11 NFKBIA PPP3CA RPS6 MAP2K6 ARPC5L ROCK2 ACACB NCL EZR OCLN STAT6 P4HA2 P4HB ITGB1 SRC PXN MAPK9 MAPK8 MAPK1 HRAS MAP2K1 MAP2K2 TRAF3IP2 FN1 PTK2 S1PR1 MAPK12 GRB2 INPP5K RAF1 IDH2 ADAMTS1 FOXO4 PRKCE PRKD2 PRKD1 MDM2 BCL2 RPL5 PLAUR PTPN11 RPL10A PIK3R2 PIK3R1 PPP2CA RPL7 PIK3CA LMAN1 PTPN6 CNP ICAM1 RPL18A CCL2 BMP2 RPLP2 RPS11 GATA2 MMP14 CYP2C8 ITGB5 NRP2 RPL13A STAT3 MAPK3 PAK1 RPL27 CFL1 RPL26 CTNNA1 YWHAE DNAJB9 PFN1 PAK2 PDIA6 CCND1 FGB FGA CALR AKT1 TEAD4 FGG PRKCB PRKCA FOXO3 TRPC3 FRS2 PLCG1 FUT1 CYCS PLCB3 BSG ETS1 MMP10 MTOR WASF1 TNFRSF25 PTGS2 IGFBP3 NCF1 FYN FADD MEF2C CSRP1 FAF1 HSPB1 EIF2AK3 VAV2 BIRC5 EIF3H EIF3F EIF3D CDH5 CSK PRDX2 BCAR1 F3 ALB NUMB FHL2 HDAC1 NAPA NOTCH4 CSRP2 DLL4 SRF NR4A3 SIAH2 CDC42 JAG1 CAMKK2 ITCH GNB2L1 MIR7705 GLUD1 MYH9 DUSP5 SDCBP CALU ENG PABPC1 LDB2 ASCC3 STAT1 RPS6KA5 GRB10 MAP2K4 EIF2A CCRL2 HDAC4 SHC2 PLA2G5 ATF6 HDAC9 SHC1 HDAC7 PRKCZ FOXO1 NFATC2 NAP1L1 MAP2K7 EGR1 TCEB1 RAB4A OCRL ANXA1 SLC8A1 RHOC ATP6V1E1 PTPRZ1 RAC1 PDPK1 RCAN1 GAB1 PRKG1 RHOJ RAPGEF1 CRK GPX1 ARF6 PRKAA1 CBL CYBB SOD2 EIF4E NOX4 PTPN1 MYO1C RPS6KB1 IGFBP7 BIN1 CACNA2D1 ACTG1 RAP1B RAP1A CTGF PPP1CA NDRG1 CREB1 PLOD3 KL STAM SEMA6D FLNB DECR1 TAOK2 FAS HSPA1A MAPKAPK2 MAPKAPK5 CREBBP FLT1 NOS3 ARNT KDR VPS39 MAPKAP1 RICTOR RAB5A MYO6 EPS15 EGR3 PLA2G4A TPCN2 PRKRA MYL2 MKNK1 HERPUD1 CAPN2 NCK1 VCL QKI DNAJA1 CAV1 FBXW11 SELE LUC7L LRRFIP2 IER5 ACOT9 SND1 EWSR1 TXNIP FLII EIF4G2 GIGYF2 LARP7 TCEB3 TRIP4 PRRC2C MOV10 GIPC1 HYOU1 ARF4 KCNC3 EPRS SRP54 SHB EEA1 SH3BGRL3 PNP CGNL1 PGD SSR4 TKT SSR3 TAL1 KANK1 SLC7A1 APOLD1 NCF2 FGD5 BRD4 EPB41 TMSB10 SARS ARMCX1 RAB37 FSCN1 ADAM9 ZNF555 DSC1 LRRC59 STIP1 TXNDC5 SDF2L1 TNFRSF10C TFCP2 SYNJ1 RCAN2 SPIRE1 TPP1 NRARP CAPZB ADAMTS9 ACP1 TRPC1 SLC25A11 HLX PBXIP1 MLLT4 PPM1G DNAJB4 SLC25A25 CDC42BPB PTPN14 PTPN9 UBAP2L IQGAP1 CHAC1 TMEM170A INPP4B KATNAL2 ATP6V0D1 SH2D2A MIR4329 FXR2 DHX36 BMP10 MICAL2 SRPK1 DHX29 CCDC124 PTPRJ HBD CLIC1 PTMA FJX1 NEXN PLAU CRIP2 FARSB GPC1 CCT7 COPG1 FHOD1 AMOT TMOD1 TMOD3 HTRA1 SCUBE2 MYH11 ZC3H15 DKK1 TBCA GRSF1 C15orf39 RND1 ARHGEF15 SHROOM2 EPN1 RCN1 RAB11A MMRN2 CASC10 USP10 FAM120A ABCF2 RBM39 PDE4DIP FMNL3 EPHB2 ROCK1 SET ADAM10 JUN ABL1 LIMK1 HIPPO-MERLIN SIGNALING DYSREGULATION%WIKIPATHWAYS_20200510%WP4541%HOMO SAPIENS Hippo-Merlin Signaling Dysregulation RBX1 CUL4A DDB1 ITGB1 PDGFRA EGFR FLT1 NRAS MIR98 HRAS ITGA1 KDR PTK2 CTNNB1 TEK KRAS CDH13 ITGAE ITGAX ITGAD PDGFRB FGFR3 FGFR2 MET FGFR1 CDH11 AJUBA CD44 VGLL4 VPRBP IGF1R NTRK1 NTRK2 PRKAR1B ITGA3 PRKAR1A PPP1R12A ITGA8 PRKAR2B PRKAR2A ITGB5 ITGB4 ITGB2 ITGAL TAZ STK3 SAV1 PAK1 PPP1R14A NGFR CDH1 EPHA2 CTNNA1 ITGAM PAK7 CXCL10 ITGB8 PAK6 ITGB7 ITGB6 PAK3 INSR FOXM1 PAK2 CCND1 TEAD1 TEAD2 PAK4 TEAD3 TEAD4 MST1 YY1AP1 LATS1 NF2 CDH6 CDH2 CDH16 KIT ITGA2B FGFR4 PLCB4 CSF1R MIR4329 LIN28B ITGA10 ITGA11 MYC FLT4 AMOT ITGA4 ITGA2 FLT3 ITGA7 ITGA6 ITGB3 ITGAV ITGA5 ITGA9 PPP1CC PRKACG PRKACA CDH9 PRKACB CDH8 CDH7 CTGF CDH5 CDH4 PPP1CA CDH3 CDH20 PPP1CB CDH22 LATS2 CDH24 CDH10 CDH12 CDH15 CDH17 CDH18 CDH19 DNA DAMAGE RESPONSE%WIKIPATHWAYS_20200510%WP707%HOMO SAPIENS DNA Damage Response RB1 CDKN1A CDK1 CASP9 PIDD1 CASP8 CCNB1 CCND1 CHEK2 CHEK1 CASP3 TLK1 FAS NBN H2AFX MRE11A CDC25C DDB2 CDC25A RAD50 RRM2B RAD51 FANCD2 TP53 RAD9A E2F1 BID PML GADD45B GADD45A GADD45G CDK6 BBC3 CDK4 HUS1B BAX TLK2 CYCS ATRIP CDKN1B CCNE2 BRCA1 APAF1 CCNE1 RAD52 CDK5 CDK2 PRKDC RAD17 MDM2 RAD1 ATR ATM CCND3 MIR3191 TP53AIP1 CCND2 MIR3190 PMAIP1 MYC TNFRSF10B SMC1A CREB1 CCNB3 CCNB2 ABL1 SFN SESN1 RFC1 RPA2 REGUCALCIN IN PROXIMAL TUBULE EPITHELIAL KIDNEY CELLS%WIKIPATHWAYS_20200510%WP4838%HOMO SAPIENS Regucalcin in proximal tubule epithelial kidney cells TGFB1 PDE1B CASP9 CASP8 TNFSF11 CASP3 ACTA2 AKT1 TGFBR1 TNFRSF1A NOS1 CALCA SMAD2 PIK3CA G3BP1 PTH SEC16B RGN TRPV5 MCU MAPK1 BAK1 FFAR3 MAP3K5 SMAD4 BRAF RAF1 BAX PRKCQ RELA PPP3R1 APAF1 MTOR SENESCENCE AND AUTOPHAGY IN CANCER%WIKIPATHWAYS_20200510%WP615%HOMO SAPIENS Senescence and Autophagy in Cancer GSK3B CEBPB CDC25B SRC MAPK1 HRAS MAP2K1 FN1 MLST8 COL1A1 COL3A1 AKT1S1 RAF1 SQSTM1 CDKN1B COL10A1 SERPINE1 MDM2 SERPINB2 THBS1 BCL2 SLC39A2 CD44 SLC39A1 SLC39A4 INHBA SLC39A3 IGF1R ATG5 LAMP1 BMP2 LAMP2 GABARAPL2 GABARAPL1 FKBP8 GABARAP TNFSF15 IL24 RNASEL BMI1 ING1 ING2 IFI16 MMP14 CREG1 RSL1D1 SH3GLB1 UVRAG AMBRA1 RB1 ATG14 PLAT KMT2A CDKN1A ATG16L1 CXCL1 MAP1LC3B MAP1LC3C TP53 MIR29B2 CXCL8 HMGA1 E2F1 IFNB1 IL6ST CDKN2A IL6R BRAF BECN1 ATG3 ATG10 ATG13 MTOR ATG12 MAP1LC3A RB1CC1 TGFB1 ULK1 IRF1 PIK3C3 VTN ATG7 IRF7 IRF5 GSN IGFBP7 IL3 IGFBP3 PLAU CXCL14 PTEN SPARC IGF1 IFNG MAP2K3 SMAD4 INS SMAD3 PCNA CCL3 MAPK14 IGFBP5 JUN IL6 IL1A IL1B DNA MISMATCH REPAIR%WIKIPATHWAYS_20200510%WP531%HOMO SAPIENS DNA Mismatch Repair RPA4 PMS1 EXO1 RPA3 PCNA POLD3 POLD4 PMS2 POLD1 POLD2 RFC5 RFC3 RFC4 MLH3 LIG1 MLH1 RFC1 MSH6 RFC2 MSH2 RPA1 RPA2 INTERACTIONS BETWEEN IMMUNE CELLS AND MICRORNAS IN TUMOR MICROENVIRONMENT%WIKIPATHWAYS_20200510%WP4559%HOMO SAPIENS Interactions between immune cells and microRNAs in tumor microenvironment MIR203A TGFB1 CXCL10 CD274 TGFB3 MIR27A IL4R IRAK4 TGFBR2 TRAF6 CD86 MIR212 STAT6 CD80 IL4 MIR138-1 PIAS3 TLR8 CTLA4 PDCD1 CCL2 MIR23A TLR7 CCL5 TGFB2 IL2RG MIR210 TLR4 NFKB2 IL2RA NFKB1 STAT3 IL2RB SOCS1 REGULATORY CIRCUITS OF THE STAT3 SIGNALING PATHWAY%WIKIPATHWAYS_20200510%WP4538%HOMO SAPIENS Regulatory circuits of the STAT3 signaling pathway F2RL2 PTPRT CNTFR MPL IL27RA IL11RA IL9R IL20RA IL20RB CSF2RA JAK3 TYK2 IL21R IL15RA MAPK15 RPTOR PTPRD PRKCB IL22RA1 SRC PIAS3 OSMR PDGFRA LIFR EGFR IL5RA MAPK9 CSF2RB MAPK8 CREBBP MAPK1 IL6ST DEPTOR TRIM28 MLST8 CSF3R MAPK12 MAPK13 CTF1 MAPK10 MAPK11 IL6R AKT1S1 IL2RG PTPRC MAPK7 MAPKAP1 IL2RA IL7R MAPK6 MAPK4 PDGFRB RICTOR MTOR AGTR1 AGTR2 DUSP2 IL12RB2 IFNGR1 IFNGR2 GHR IFNLR1 IL3RA STMN1 IFNAR2 F2R F2RL3 MIR3917 SETD7 IFNAR1 IL10RB IL10RA MAPK14 STAT3 JAK2 MAPK3 IL2RB JAK1 SOCS3 APOPTOSIS MODULATION AND SIGNALING%WIKIPATHWAYS_20200510%WP1772%HOMO SAPIENS Apoptosis Modulation and Signaling TNFRSF11B CASP9 HTRA2 PIDD1 CASP8 CASP2 BIRC7 CASP3 RIPK1 FAS CRADD MAP3K14 HSPA1A ENDOG AIFM1 TP53 TNFRSF6B AIFM2 MAPK8 PEA15 SEPT4 PTRH2 BIRC6 BAG3 BAK1 TNFRSF10A BID TNFRSF10D MAP3K5 TNFRSF10C TOLLIP BAD CDKN2A HRK TRADD BBC3 CASP7 BAX CASP6 FOS CYCS CAPNS1 CASP10 CASP4 CASP1 BCL2L1 BOK DFFB DFFA APAF1 TNFRSF1B FASLG TRAF3 MIR7846 PRKD1 TNFRSF25 BCL2A1 BIRC2 BIRC3 MIR3191 DIABLO TNFRSF1A MIR3190 BCL2 XIAP PMAIP1 BNIP3 TRAF6 FADD TNFRSF10B BCL2L2 BCL2L10 DAXX IL1R1 NAIP IL1R2 IRAK1 BLK TNFSF10 BIRC5 MIR718 BCL2L11 BMF MCL1 MYD88 CFLAR PTPN13 MADD BIK NFKB1 IKBKB JUN NFKBIA MAPK3 MOLYBDENUM COFACTOR (MOCO) BIOSYNTHESIS%WIKIPATHWAYS_20200510%WP4507%HOMO SAPIENS Molybdenum cofactor (Moco) biosynthesis MARC2 MOCS1 GPHN SUOX AOX1 XDH MOCS2 DEGRADATION PATHWAY OF SPHINGOLIPIDS, INCLUDING DISEASES%WIKIPATHWAYS_20200510%WP4153%HOMO SAPIENS Degradation pathway of sphingolipids, including diseases GLB1 GLA NEU2 ARSA NEU3 NEU4 GM2A HEXB HEXA NEU1 REGULATION OF WNT/B-CATENIN SIGNALING BY SMALL MOLECULE COMPOUNDS%WIKIPATHWAYS_20200510%WP3664%HOMO SAPIENS Regulation of Wnt/B-catenin Signaling by Small Molecule Compounds SFRP4 MBOAT1 FZD8 CSNK1A1 TNKS APC CTNNB1 GSK3B DVL2 AXIN1 WNT1 LRP1 TCF4 MIR4683 FZD1 LEF1 DKK3 FZD7 NCRNAS INVOLVED IN WNT SIGNALING IN HEPATOCELLULAR CARCINOMA%WIKIPATHWAYS_20200510%WP4336%HOMO SAPIENS ncRNAs involved in Wnt signaling in hepatocellular carcinoma SOX7 FZD6 FZD9 FZD8 FOSL1 CCND1 EZH2 GSK3B WNT2B CHD8 SOST KREMEN1 AXIN1 SENP2 WNT16 LEF1 LRP5 CXXC4 NKD1 NKD2 LRP6 WNT11 WIF1 TCF7L2 TCF7L1 RYK CSNK1A1 WNT7B WNT7A MIR6808 APC CTNNB1 NOTUM CSNK1A1L ELAVL1 DANCR FZD10 CCND3 FRAT1 FRAT2 CCND2 SOX17 PLAU MYC CER1 WNT5B CSNK2A1 CSNK2A3 SERPINF1 CSNK2A2 CTNNBIP1 WNT5A CSNK1E MIR320A DKK1 DKK2 DKK4 SFRP4 SFRP1 SFRP2 SFRP5 CSNK2B ROR1 ROR2 CTBP2 CTBP1 TCF7 NLK WNT6 PORCN DVL1 DVL2 DVL3 WNT1 WNT2 MIR4683 WNT3 WNT4 MTDH FZD1 WNT10B JUN FZD3 WNT10A FZD2 FZD5 WNT3A KLF4 FZD7 CELL MIGRATION AND INVASION THROUGH P75NTR%WIKIPATHWAYS_20200510%WP4561%HOMO SAPIENS Cell migration and invasion through p75NTR KIDINS220 EFNA5 EFNA4 MMP8 CDH11 EFNB1 ADAMTS13 EFNB3 AKT2 EFNA1 AKT1 EFNA3 MIR3620 EFNA2 ARF1 PARD3 RAC1 AKT3 NTRK2 MMP9 MMP2 TRIO RHOA TIAM1 BDNF EFNB2 JUN STAT3 PAK1 TWIST1 NGFR ROBO4 AND VEGF SIGNALING PATHWAYS CROSSTALK%WIKIPATHWAYS_20200510%WP3943%HOMO SAPIENS Robo4 and VEGF Signaling Pathways Crosstalk ROBO4 SLIT2 VEGFA KDR SRC RAC1 LIPID METABOLISM PATHWAY%WIKIPATHWAYS_20200510%WP3965%HOMO SAPIENS Lipid Metabolism Pathway AKT2 PRKAG1 ABHD5 AKT1 HILPDA PRKAG2 PRKAG3 PNPLA2 PRKAB2 ACSBG1 PLIN1 PRKAB1 LIPE AKT3 ACLY PRKAR1B PRKAR1A FASN PRKACG PRKACA PRKACB BCKDHA PRKAA1 PRKAR2B PRKAR2A PRKAA2 ACACA PDHA1 ACSS2 DNA IR-DOUBLE STRAND BREAKS (DSBS) AND CELLULAR RESPONSE VIA ATM%WIKIPATHWAYS_20200510%WP3959%HOMO SAPIENS DNA IR-Double Strand Breaks (DSBs) and cellular response via ATM MDC1 CASP9 RASSF1 CHEK2 CHEK1 CASP3 TP53BP1 NBN LATS1 H2AFX MRE11A CDC25C DCLRE1C RAD50 RAD51 FANCD2 TP53 RAD9A TP73 E2F1 BAK1 TRIM28 EXO1 ACTL6A BID UPF1 NABP2 PARP1 CDKN2A ATF2 MCPH1 BAX BRCA1 BRCA2 APAF1 RAD52 KAT5 CDK5 PRKDC RAD17 MDM2 ATR ATM SMC3 RIF1 BLM RNF8 HSF1 TRAF6 TERF2 YAP1 SMC1A PCNA ABL1 STK3 ARYL HYDROCARBON RECEPTOR PATHWAY%WIKIPATHWAYS_20200510%WP2873%HOMO SAPIENS Aryl Hydrocarbon Receptor Pathway JUND TGFB1 IL12B IL2 UGT1A7 CYP1A2 SERPINB2 POLK IGFBP1 IL17B MYOF SRC SLC7A5 IL12A ALDH3A1 AHRR EGFR CES3 HES1 UGT1A1 PTGES3 AIP ARNT MIR1281 MGST1 UGT1A9 IFNG UGT1A4 HSP90AA1 UGT1A3 JUNB NCOA1 CAP2 UGT1A6 NQO1 GSTA2 BAX AHR TNF CYP1B1 CDKN1B EP300 JUN CYP1A1 MIR1181 CDC37 NFE2L2 IL1B NICOTINE METABOLISM%WIKIPATHWAYS_20200510%WP1600%HOMO SAPIENS Nicotine Metabolism FMO3 UGT1A9 AOX1 UGT1A4 CYP2A6 CYP2B6 VALPROIC ACID PATHWAY%WIKIPATHWAYS_20200510%WP3871%HOMO SAPIENS Valproic acid pathway CYP2C9 UGT1A3 HADHB HADHA CYP2A6 HSD17B10 HDAC1 EHHADH ACSM1 ACADSB ABAT IVD CYP2B6 ADIPOGENESIS%WIKIPATHWAYS_20200510%WP236%HOMO SAPIENS Adipogenesis LPL NCOR2 NCOR1 LEP FAS LPIN2 EGR2 CEBPA BMP1 CEBPB HNF1A STAT6 GATA3 FOXC2 MEF2BNB-MEF2B MIR6808 CTNNB1 ZMPSTE24 LMNA NAMPT AGPAT2 CYP26A1 TWIST1 FRZB SERPINE1 LIF ID3 SREBF1 IRS1 CFD RETN PNPLA3 BMP4 IRS4 IRS2 LIPE STAT1 NR1H3 ADIPOQ BMP2 STAT2 RBL1 SCD MIXL1 MIF GATA2 TRIB3 RORA AHR STAT3 FOXO1 SOCS3 EPAS1 SOCS1 RB1 CDKN1A E2F4 CNTFR PCK2 PPARG PPARA DLK1 PPARD LIFR HMGA1 E2F1 RARA OSM IL6ST NRIP1 RXRG STAT5A NCOA2 STAT5B GADD45B GADD45A KLF15 PTGIS KLF5 NDN PRLR SP1 PCK1 AGT TGFB1 MEF2D MEF2A GH1 WNT5B MEF2C PLIN1 RBL2 CISD1 EBF1 MBNL1 GATA4 GTF3A BSCL2 UCP1 WWTR1 SFRP4 NR2F1 BMP3 HIF1A CELF1 IGF1 PLIN2 ASIP SPOCK1 GDF10 KLF7 KLF6 LPIN3 DDIT3 PPARGC1A NCOA1 INS DVL1 SMAD3 SLC2A4 CEBPD LPIN1 WNT1 NR3C1 CREB1 TNF FZD1 CYP26B1 WNT10B IL6 RXRA NOVEL INTRACELLULAR COMPONENTS OF RIG-I-LIKE RECEPTOR (RLR) PATHWAY%WIKIPATHWAYS_20200510%WP3865%HOMO SAPIENS Novel intracellular components of RIG-I-like receptor (RLR) pathway TKFC CXCL10 PIN1 TBKBP1 CASP8 RIPK1 NLRX1 IFNA1 CXCL8 MAPK9 MAPK8 ISG15 IFNB1 SNW1 MAPK12 TANK MAPK13 MAPK10 MAPK11 TRADD IFIH1 MIR3614 CXCL12 CASP10 TRIM25 DDX58 TMEM173 RNF125 ATG12 IRF3 TRAF3 CYLD MAVS IRF7 TRAF2 TRAF6 FADD MAP3K7 NFKBIB TBK1 IKBKE ATG5 DDX3X IFNG MAP3K1 CHUK OTUD5 MAPK14 TNF RELA NFKB1 IKBKB DDX3Y NFKBIA DHX58 AZI2 DDX17 SIKE1 IFNE IKBKG IFNK METAPATHWAY BIOTRANSFORMATION PHASE I AND II%WIKIPATHWAYS_20200510%WP702%HOMO SAPIENS Metapathway biotransformation Phase I and II CYP2S1 HS6ST1 HS6ST2 CYP26C1 HS6ST3 NDST2 SULT1C2 NDST1 CYP4Z1 NDST4 NDST3 GSTK1 CYP39A1 CYP2U1 SULT6B1 HS3ST3A1 GSTCD CYP4F22 CYP4X1 NAT2 CHST12 SULT1A2 CHST10 CHST13 SULT1A4 GSTT2B SULT1A3 NAA50 EPHX1 CYP4F3 AKR1A1 CYP4F8 AKR1C4 CYP4F11 MIR4761 SULT1B1 NAT6 CYP27C1 AKR1B10 NAT8 NAT9 NAA40 NAT10 NAT14 HS2ST1 SULT1C3 CYP2D6 CYP4V2 GAL3ST2 CYP3A43 CYP26A1 SULT4A1 GAL3ST3 SULT1C4 HS3ST3B1 CHST8 CHST9 NAA30 CHST6 CHST7 GSTO2 GSTO1 KCNAB1 KCNAB2 KCNAB3 CYP2A7 CHST1 CYP46A1 NAT8L CHST4 CHST5 CHST2 NAA20 AKR1D1 HS3ST5 HS3ST6 EPHX2 HS3ST4 CYP7B1 HS3ST1 GSTZ1 CYP2W1 CYP20A1 SLX1A-SULT1A3 CYP51A1 GSTM1 MGST3 GSTA1 MGST2 CYP27A1 GSTM4 GSTM3 CYP19A1 UGT2B4 GAL3ST1 CYP2C18 GSTM5 UGT2B15 CYP2A13 FMO1 FMO3 CYP2C8 SULT1E1 CYP1B1 CYP2F1 CYP2J2 UGT2B7 CHST11 GPX5 CYP7A1 CYP27B1 CYP2B6 GSTP1 CYP4F2 CYP4B1 UGT1A7 CYP8B1 CYP2C9 CYP24A1 CYP1A2 GSTA4 GSTA3 TPMT CYP2E1 NNMT FMO2 INMT CYP17A1 FMO4 FMO5 HNMT GPX4 UGT2B28 CHST14 UGT1A5 UGT2A3 UGT2A2 CHST3 UGT2A1 UGT2B10 UGT2B11 UGT2B17 UGT1A10 UGT1A1 GAL3ST4 CYP3A4 CYP3A5 AKR1B1 SULT2A1 MGST1 UGT1A9 GSTT2 HS3ST2 UGT1A6 GPX3 CYP21A2 AKR1C1 GSR AKR1C3 AKR1C2 SULT2B1 CYP1A1 CYP11A1 CYP11B2 CYP3A7 CYP4F12 GSS AKR7A2 AKR7A3 CYP11B1 GLYATL2 GSTM2 GLYATL1 GLYAT GPX2 GSTA5 BAAT CYP2C19 SULT1A1 UGT1A4 UGT1A3 CYP2R1 CYP2A6 COMT GSTA2 CYP26B1 METABOLISM OF ALPHA-LINOLENIC ACID%WIKIPATHWAYS_20200510%WP4586%HOMO SAPIENS Metabolism of alpha-linolenic acid ALOX5 MIR1908 ALOX15 FADS2 PTGS2 ALOX12 FADS1 FELBAMATE METABOLISM%WIKIPATHWAYS_20200510%WP2816%HOMO SAPIENS Felbamate Metabolism CYP3A4 CYP2E1 MICRORNA NETWORK ASSOCIATED WITH CHRONIC LYMPHOCYTIC LEUKEMIA%WIKIPATHWAYS_20200510%WP4399%HOMO SAPIENS MicroRNA network associated with chronic lymphocytic leukemia ZAP70 TP53 MIR16-1 MCL1 BCL2 DOPAMINE METABOLISM%WIKIPATHWAYS_20200510%WP2436%HOMO SAPIENS Dopamine metabolism PPP2CB TH MAOA MIR4761 PRKACG MAOB PRKACA NQO1 PRKACB COMT TYR SOD1 DDC PPP2CA BLOOD CLOTTING CASCADE%WIKIPATHWAYS_20200510%WP272%HOMO SAPIENS Blood Clotting Cascade F10 F12 SERPINE1 PLAT VWF PLG F3 F13B KLKB1 FGB FGA F2 SERPINB2 FGG PLAU SERPINF2 F5 F8 F8A1 F9 KLK1 F11 F7 TGF-BETA SIGNALING PATHWAY%WIKIPATHWAYS_20200510%WP366%HOMO SAPIENS TGF-beta Signaling Pathway MAP2K6 BCAR1 CDK1 RBX1 FOXH1 PIAS1 TGFB1I1 COL1A2 HDAC1 AXIN1 CUL1 PIAS2 SUMO1 COPS5 ITGB1 SRC SMAD2 MAPK9 CREBBP CDC42 MAPK8 UBE2I MAPK1 LIMK2 ITCH SNW1 MAP2K1 MIR1281 MAP2K2 DAB2 FN1 PTK2 GRB2 ZEB1 SOS1 RAF1 BTRC TAB1 HGS SIK1 MET ZFYVE9 CDKN2B TGIF1 TGFBR3 ZEB2 THBS1 TGFBR1 TGFBR2 SKIL PPM1A TERT TRAF6 SMAD7 SKI PIK3R2 PIK3R1 SMURF1 RBL1 CAV1 MAP2K4 PRKAR2A ITGB4 SHC1 SPTBN1 CCNB2 TRAP1 RUNX2 TFDP1 CDKN1A STRAP E2F4 PAK2 CCND1 AKT1 PDK1 MMP12 SIN3A TP53 KLF10 MMP1 SNIP1 E2F5 RNF111 NUP214 RAC1 EID2 MAP4K1 ZFYVE16 NEDD4L SMURF2 NUP153 FOXP3 DCP1A PML CITED1 KLF11 UCHL5 TNC PJA1 NEDD9 JUNB STAMBPL1 WWP1 ATF2 RHOA FOS SP1 MAPK4 ETS1 TGFB1 JUND MEF2A MYC FOSB MAP3K7 MEF2C ITGA2 RBL2 ITGB3 YAP1 ATF3 KLF6 MAP2K3 SMAD4 SMAD3 MAPK14 APP ROCK1 PARD6A EP300 JUN SKP1 1Q21.1 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20200510%WP4905%HOMO SAPIENS 1q21.1 copy number variation syndrome AMELX NBPF12 CHD1L PYGO2 GJA5 LINC00624 TJP3 TJP2 NOTCH2 PRKAG1 OCLN PRKAG2 PRKAG3 FMO5 GJA3 GJA8 PRKAB2 PRKAB1 GJA1 TJP1 KIRREL CTNNB1 PYGO1 BCL9 PRKAA1 MLLT4 PRKAA2 NOTCH2NL F11R ACP6 SULFATION BIOTRANSFORMATION REACTION%WIKIPATHWAYS_20200510%WP692%HOMO SAPIENS Sulfation Biotransformation Reaction SULT1A4 SULT1A3 SULT2A1 SULT1A1 SULT1B1 SULT1C2 GSR SULT1C3 SLX1A-SULT1A3 G6PD SULT2B1 SULT4A1 SULT1E1 SULT1C4 PAPSS1 SULT6B1 PAPSS2 SULT1A2 REGULATION OF SISTER CHROMATID SEPARATION AT THE METAPHASE-ANAPHASE TRANSITION%WIKIPATHWAYS_20200510%WP4240%HOMO SAPIENS Regulation of sister chromatid separation at the metaphase-anaphase transition ESPL1 BUB3 BUB1 CDC20 PTTG1 SMC3 SMC1A MIR3610 RAD21 MAD1L1 ANAPC2 ANAPC11 BUB1B MAD2L1 STAG1 CENPE ATM SIGNALING NETWORK IN DEVELOPMENT AND DISEASE %WIKIPATHWAYS_20200510%WP3878%HOMO SAPIENS ATM Signaling Network in Development and Disease KAT5 CDK5 CDK1 MDC1 PRKDC RASGRF1 BUB1 ATR CHEK2 CHEK1 ATM TP53BP1 RIF1 NBN LBR RNF8 H2AFX STK11 MRE11A DCLRE1C G6PD RAD50 PPM1D HMGN1 CDK5R1 HSPB1 RNF20 ATMIN RNF40 RNF168 CEP63 TRIM28 MIR4741 MAP3K5 PPP2R4 ATF2 SMC1A TSC2 HDAC4 PRKAA1 PPP5C RBBP8 AURKB NFKB1 MTOR IKBKG ETHANOL METABOLISM RESULTING IN PRODUCTION OF ROS BY CYP2E1%WIKIPATHWAYS_20200510%WP4269%HOMO SAPIENS Ethanol metabolism resulting in production of ROS by CYP2E1 PRKCQ MAP2K1 MAP2K2 SP1 MAFK CYP2E1 MAPK8 MAFG NFE2L2 MAFF ARACHIDONATE EPOXYGENASE / EPOXIDE HYDROLASE%WIKIPATHWAYS_20200510%WP678%HOMO SAPIENS Arachidonate Epoxygenase / Epoxide Hydrolase GSTP1 CYP2C8 COX8A CYP2J2 CYP2C9 EPHX2 COX5A UNFOLDED PROTEIN RESPONSE%WIKIPATHWAYS_20200510%WP4925%HOMO SAPIENS Unfolded protein response XBP1 TXNIP ATF4 CASP8 CASP2 MIR3191 MBTPS1 MIR3190 BCL2 PMAIP1 TNFRSF10B TP53 MBTPS2 HSPA5 EIF2AK3 EIF2S1 BID RTCB DDIT3 BCL2L11 ERN1 BBC3 ATF6 PPP1R15A NFE2L2 IL1B VITAMIN B12 METABOLISM%WIKIPATHWAYS_20200510%WP1533%HOMO SAPIENS Vitamin B12 Metabolism CRP PLAT PLG APOB INSR ALB SAA1 SAA2 MMAB TCN1 MTR MAT1A MUT GIF SOD2 NFKB2 SOD3 CUBN SHMT2 SOD1 CBS MIR6886 LDLR SERPINE1 CTH ABCA1 HBA1 APOA1 F7 MTRR ICAM1 TCN2 CCL2 IFNG APOE F2 MCEE LRP2 INS MTHFR SCARB1 HBB CCL5 MPO TNF RELA NFKB1 SAA3P SAA4 IL6 IL1B BREAST CANCER PATHWAY%WIKIPATHWAYS_20200510%WP4262%HOMO SAPIENS Breast cancer pathway FZD6 FZD9 FZD8 ESR1 TNFSF11 GSK3B NOTCH2 WNT2B NOTCH3 FGF1 NOTCH1 APC2 FGF3 FGF4 NOTCH4 AXIN1 FGF5 FGF6 AXIN2 FGF7 FGF9 WNT16 LEF1 DLL1 LRP5 DLL3 DLL4 PIK3CD EGFR LRP6 HES5 JAG2 WNT11 NRAS AKT3 TCF7L2 MAPK1 TCF7L1 HRAS MAP2K1 CSNK1A1 MAP2K2 WNT7B FGF2 WNT7A MIR6808 APC CTNNB1 FGF20 CSNK1A1L FGF23 FGF22 KRAS FGF21 GRB2 SOS1 RAF1 NFKB2 FGF17 FGF16 FGF18 BRCA1 BRCA2 FGF10 FGFR1 ATR ATM PIK3R3 PIK3R2 PIK3R1 IGF1R PIK3CA SHC2 SHC3 SHC1 ESR2 MAPK3 RB1 CDKN1A ARAF CCND1 AKT2 AKT1 POLK NBN PGR MRE11A DDB2 RAD50 SOS2 RAD51 TP53 KIT ERBB2 E2F1 E2F2 E2F3 BAK1 GADD45B GADD45A PARP1 EGF BRAF GADD45G CDK6 CDK4 BAX FOS SP1 FGF19 MTOR RPS6KB1 RPS6KB2 NCOA3 FZD10 FRAT1 FRAT2 MYC FLT4 WNT5B CSNK2A1 CSNK2A3 SHC4 CSNK2A2 PTEN WNT5A HEY1 HES1 SFRP4 IGF1 CSNK2B TCF7 NCOA1 WNT6 DVL1 DVL2 CETN3 DVL3 HEYL WNT1 WNT2 MIR4683 WNT3 WNT4 FZD1 HEY2 FGF8 WNT10B JUN FZD3 WNT10A SKP1 FZD2 FZD5 WNT3A FZD7 TUMOR SUPPRESSOR ACTIVITY OF SMARCB1%WIKIPATHWAYS_20200510%WP4204%HOMO SAPIENS Tumor suppressor activity of SMARCB1 RB1 MIR4738 SMO EZH2 SUZ12 EED MIR6755 SMARCB1 DPF1 DPF3 SMARCC1 ACTL6A ARID1A GLI1 ARID1B SMARCC2 SMARCD1 SMARCD2 CDKN2A ACTL6B SMARCD3 RBBP4 CDK6 SMARCE1 SMARCA4 CDK4 GLI4 PTCH1 DPF2 GLI3 GLI2 H3F3B H3F3A FATTY ACID OMEGA OXIDATION%WIKIPATHWAYS_20200510%WP206%HOMO SAPIENS Fatty Acid Omega Oxidation CYP3A4 CYP4A11 ALDH1A1 CYP1A2 CYP2E1 ADH1C ADH1B CYP2A6 ADH1A ADH7 CYP2D6 ALDH2 ADH4 ADH6 CYP1A1 CYP4A22 OXYTOCIN SIGNALING%WIKIPATHWAYS_20200510%WP2889%HOMO SAPIENS Oxytocin signaling CD38 PLCD1 GNAQ OXTR MEVALONATE PATHWAY%WIKIPATHWAYS_20200510%WP3963%HOMO SAPIENS Mevalonate pathway MVK FDPS HMGCR HMGCS1 ACAT2 PMVK MVD METABOLIC PATHWAY OF LDL, HDL AND TG, INCLUDING DISEASES%WIKIPATHWAYS_20200510%WP4522%HOMO SAPIENS Metabolic pathway of LDL, HDL and TG, including diseases LPL APOB LIPC CETP MTTP LCAT APOE ANXA2 SCARB1 ABCA1 APOA2 APOA1 MIR6886 LDLR LIPG LDLRAP1 PCSK9 CODEINE AND MORPHINE METABOLISM%WIKIPATHWAYS_20200510%WP1604%HOMO SAPIENS Codeine and Morphine Metabolism ABCC3 UGT1A1 CYP3A4 SLCO1B1 UGT1A9 UGT1A3 UGT1A6 UGT2B4 CYP2D6 CYP2C8 ABCB1 UGT1A8 UGT2B7 UGT1A10 ABCC2 PEROXISOMAL BETA-OXIDATION OF TETRACOSANOYL-COA%WIKIPATHWAYS_20200510%WP1941%HOMO SAPIENS Peroxisomal beta-oxidation of tetracosanoyl-CoA SCP2 ACAA1 HSD17B4 ACOX1 DICLOFENAC METABOLIC PATHWAY%WIKIPATHWAYS_20200510%WP2491%HOMO SAPIENS Diclofenac Metabolic Pathway CYP2C18 CYP2C8 CYP2C19 CYP2B6 MESODERMAL COMMITMENT PATHWAY%WIKIPATHWAYS_20200510%WP2857%HOMO SAPIENS Mesodermal Commitment Pathway TWSG1 EOMES MACF1 WDHD1 C2orf44 FZD8 C6orf201 ZNF281 CCDC88A FOXH1 MSGN1 ARL4A C9orf72 PIAS1 ACVR2A MEIS1 WDFY2 TOX BCORL1 GATA6 AXIN1 MBTD1 HNF4A EPB41L5 AXIN2 C11orf30 CSRP2 GATA3 UBR5 FOXC2 FOXC1 LEF1 DLL1 SMAD2 SRF MIR4321 ATP8B2 CHRD SMAD1 PBX3 GDF3 SETD2 AMH BMP7 ZFHX4 TCF7L1 TRERF1 PBX1 EXT1 NABP2 TBX1 PLCH1 NANOG NODAL BMPR1A TRIM71 SCHIP1 NCAPG2 PHF6 IQCJ-SCHIP1 TRIM5 HES7 ZIC3 C1QBP FGFR1 DNMT3B JARID2 TBX6 FOXA2 VAV3 SLC2A12 NOG TET1 MIR372 POU5F1 PARP8 TOX3 AEBP2 DDAH1 MTF2 CCDC6 INHBA AHDC1 SMAD6 HAND1 FZD4 BMP4 BMPR2 MIR373 ASCC3 PPP2CA ZNF462 ZIC5 ELP4 GRHL2 PAX6 MIR141 RGS10 SNAI1 PRKAR1A MIXL1 RPL38 ACVR2B TBX3 CUL4B RARG ACVR1 KLF4 HMGA2 CCND1 TEAD1 TEAD2 EXT2 BHLHE40 LATS1 RARB HPRT1 HTT ZIC2 TRIM28 KLF5 ACACA NFE2L2 MIR302C MIR125B1 LEFTY2 LEFTY1 SOX17 TCF4 DKK1 YAP1 CTBP2 KDM6A NLK PRKACA SMAD4 SMAD3 ARID5B MIR4683 WNT3 FOXA1 CRTC1 FGF8 SOX21 SOX2 ELK4 JAK2 SESN1 CEP250 FZD5 WNT3A DIP2A PITX2 ADAM19 ERBB SIGNALING PATHWAY%WIKIPATHWAYS_20200510%WP673%HOMO SAPIENS ErbB Signaling Pathway EIF4EBP1 PAK7 MAP2K7 CDKN1A PAK6 ARAF ABL2 PAK3 PAK2 CCND1 AKT2 PAK4 GSK3B AKT1 PRKCG PRKCB CAMK2B PRKCA CAMK2D NRG2 SOS2 EREG TP53 BTC NRG4 SRC TGFA PIK3CD AREG EGFR CAMK2G MAPK9 MAPK8 ERBB2 NRAS ELK1 AKT3 PLCG2 MAPK1 HRAS MAP2K1 PDPK1 MAP2K2 PLCG1 GAB1 STAT5A PTK2 STAT5B NRG1 BAD MAPK10 CRK EGF KRAS BRAF GRB2 SOS1 RAF1 CBL ERBB4 CDKN1B MTOR ERBB3 RPS6KB1 RPS6KB2 NRG3 MDM2 MYC PIK3R3 SHC4 PIK3R2 PIK3R1 CBLB PIK3CB PIK3CA CAMK2A NCK2 NCK1 HBEGF BCL2L11 MAP2K4 SHC2 CRKL SHC3 SHC1 ABL1 JUN MAPK3 FOXO1 PAK1 ESTROGEN RECEPTOR PATHWAY%WIKIPATHWAYS_20200510%WP2881%HOMO SAPIENS Estrogen Receptor Pathway NR0B2 ESR1 CYP1A2 ACOX1 PPARA PDK4 CYP1B1 SP1 PCK1 JUN CYP1A1 STAT3 GPAM RAS SIGNALING%WIKIPATHWAYS_20200510%WP4223%HOMO SAPIENS Ras Signaling REL GAB2 PLCE1 SYNGAP1 PIK3CD PDGFRA EGFR PLA2G16 MAPK9 PLA2G10 CDC42 MAPK8 RIN1 FLT1 NRAS AKT3 PLA2G3 RASAL1 GRIN2B ZAP70 MAPK1 RASAL2 HRAS MAP2K1 RASAL3 RASGRP2 MAP2K2 TTBK1 RASGRP1 PLD2 MIR5004 RASGRP4 BRAP KDR RASGRP3 RGL1 SHOC2 RGL2 PLA2G12A TEK RASA4B PLA2G12B MAPK10 RASA4 KSR1 JMJD7-PLA2G4B RALB KRAS GRB2 PLA2G2F PLA2G2D SOS1 PLA2G2E RAF1 PLA2G2C RAPGEF5 RAB5B RAB5C PDGFRB FGFR3 RAB5A FGFR2 MET FOXO4 FGFR1 RASGRF2 GNG2 FASLG GNB1 NF1 PLA2G4F PLA2G4D PLA2G4E PLA2G4B PLA2G4C PLA2G4A PLA2G1B PLD1 RASA1 RASA2 PIK3R3 PTPN11 PIK3R2 PIK3R1 RALA RALGDS PIK3CB IGF1R PIK3CA NTRK1 NTRK2 GNG13 GNB5 SHC2 SHC3 PLA2G5 PLA2G6 KSR2 SHC1 MAPK3 PAK1 NGFR EPHA2 PAK7 PAK6 GNG10 ABL2 RASSF1 PAK3 INSR PAK2 AKT2 GNG11 RASSF5 PAK4 AKT1 PRKCG PRKCB PLA1A PRKCA SOS2 GNGT1 GNGT2 KIT STK4 RAC2 PLA2G2A RAC1 ELK1 PLCG2 PLCG1 GAB1 BAD HTR7 CALML5 RHOA ARF6 CALML6 RALBP1 LAT CALML3 CALML4 BCL2L1 MLLT4 RASA3 FGFR4 ETS1 CSF1R RASGRF1 GNB2 GNB4 GNB3 FLT4 SHC4 FLT3 ETS2 EXOC2 RAP1B GRIN2A RAP1A PRKACG PRKACA PRKACB RRAS GNG3 CHUK GNG5 TIAM1 GNG12 GNG4 GNG7 GRIN1 GNG8 RAC3 RELA NFKB1 CALM3 IKBKB RRAS2 ABL1 CALM1 CALM2 MRAS IKBKG THE HUMAN IMMUNE RESPONSE TO TUBERCULOSIS%WIKIPATHWAYS_20200510%WP4197%HOMO SAPIENS The human immune response to tuberculosis IRF1 IFNAR2 STAT2 OAS1 IFITM1 MX1 PIAS1 IFI35 IFIT1 IFIT3 IRF9 PTPN2 IFNAR1 TYK2 IFNGR1 IFNGR2 MED14 JAK2 JAK1 STAT1 TAP1 PSMB8 SOCS1 CANONICAL AND NON-CANONICAL TGF-B SIGNALING%WIKIPATHWAYS_20200510%WP3874%HOMO SAPIENS Canonical and Non-Canonical TGF-B signaling TGFB1 LOXL4 SMAD4 TGFBR1 TGFBR2 SMAD3 BMPR1A BMP1 LOX MAPK14 LOXL1 LOXL2 BMPR2 SMAD2 GREM1 MAPK9 MAPK8 COPPER HOMEOSTASIS%WIKIPATHWAYS_20200510%WP3286%HOMO SAPIENS Copper homeostasis STEAP3 ADAM17 CCND1 GSK3B CASP3 MAPT AKT1 SCO2 SLC11A2 TP53 FOXO3 ADAM9 MT1X APC BACE1 SOD3 SOD1 SP1 MT1L MT2A SCO1 MDM2 COX17 MTF2 XIAP COX11 MT4 MT3 MT1A MTF1 MT1F MT1G MT1H MT1B PRNP ATP7B MT1E ATP7A COMMD1 PTEN STEAP1 STEAP2 PIK3CA MT1JP SLC31A2 SLC31A1 ATOX1 CCS STEAP4 XAF1 APP ADAM10 JUN FOXO1 CELL-TYPE DEPENDENT SELECTIVITY OF CCK2R SIGNALING%WIKIPATHWAYS_20200510%WP3679%HOMO SAPIENS Cell-type Dependent Selectivity of CCK2R Signaling GNAI1 RYR1 CCKBR RYR3 CNR1 DAGLA GNAQ PLCB1 CD38 ITPR1 RYR2 TRPC1 CCK ARYL HYDROCARBON RECEPTOR NETPATH%WIKIPATHWAYS_20200510%WP2586%HOMO SAPIENS Aryl Hydrocarbon Receptor Netpath RB1 LPL CDKN1A CDK2 NCOR2 NF1 ESR1 PTGS2 CYP1A2 GCLC MYC RET SRC AHRR EGFR NRAS E2F1 CD36 MAPK1 HRAS NRIP1 MAP2K1 AIP ARNT VEGFA MIR1281 HPGDS HSP90AA1 KLF6 NQO1 KRAS PLAGL1 FGF21 PSRC1 NCOA7 RAF1 CCL1 AHR TNF RELA CYP1B1 CDKN1B NFKB1 EP300 CYP1A1 MIR1181 CDC37 NFE2L2 PHOTODYNAMIC THERAPY-INDUCED NF-KB SURVIVAL SIGNALING%WIKIPATHWAYS_20200510%WP3617%HOMO SAPIENS Photodynamic therapy-induced NF-kB survival signaling RELB EGLN2 CXCL2 IL2 BCL2A1 CCND1 REL BIRC2 PTGS2 BIRC3 TNFRSF1A TRAF6 BCL2L2 MMP1 MMP3 CXCL8 ICAM1 VEGFA MMP9 MMP2 BIRC5 CSF2 CFLAR CHUK CD40LG NFKB2 TNF RELA VCAM1 NFKB1 IKBKB SELE IL1A IL6 IL1B G1 TO S CELL CYCLE CONTROL%WIKIPATHWAYS_20200510%WP45%HOMO SAPIENS G1 to S cell cycle control RB1 TFDP2 CDKN1A CDK1 CCNB1 CCND1 CDKN2D RPA3 POLE2 CDC25A TP53 CDK7 CCNA1 E2F1 CDC45 E2F2 E2F3 MNAT1 GADD45A CDKN2A ATF6B PRIM2 CDK6 MCM7 CDK4 PRIM1 ORC5 CREB3L3 ORC4 CDKN1B CREB3L4 CCNE2 ORC6 CREB3L1 ORC1 ORC3 ORC2 CREB3 CCNE1 WEE1 POLA2 CDKN2B MCM3 CDKN2C MCM4 CDK2 MCM5 MCM6 MDM2 MCM2 ATM CCND3 CCND2 MYC MYT1 CDKN1C PCNA CREB1 POLE CCNG2 CCNH RPA1 TFDP1 RPA2 PHOTODYNAMIC THERAPY-INDUCED NFE2L2 (NRF2) SURVIVAL SIGNALING%WIKIPATHWAYS_20200510%WP3612%HOMO SAPIENS Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling ABCC3 GSTP1 EPHX1 CES1 MAPK12 ABCG2 MAPK13 HMOX1 GCLC KEAP1 MAPK11 NQO1 GCLM SRXN1 FOS MAPK14 NQO2 ABCC6 JUN ABCC4 MAPK8 NFE2L2 ABCC2 GPR40 PATHWAY%WIKIPATHWAYS_20200510%WP3958%HOMO SAPIENS GPR40 Pathway PLCG2 PLCD1 PLCB2 PLCG1 MIR6511B1 PLCH1 PLCB1 FFAR1 ITPR3 PLCD3 PLCL1 PLCB3 PLCZ1 PLCE1 PKD1 GNA11 HUMAN THYROID STIMULATING HORMONE (TSH) SIGNALING PATHWAY%WIKIPATHWAYS_20200510%WP2032%HOMO SAPIENS Human Thyroid Stimulating Hormone (TSH) signaling pathway RB1 RPS6 MAP2K6 RAP1GAP EGR1 ADCY3 AKT1 SRC TSHR E2F1 MAPK1 HRAS APEX1 MAP2K1 PDPK1 BRAF RAF1 CDK4 TTF2 TTF1 FOS CGA CDKN1B TSHB PAX8 GNAI2 PDE4D CCNE1 MTOR ADCY2 GNG2 RPS6KB1 GNB1 CDK2 GNAO1 CCND3 GNAQ PLD1 MYC MYL12B PIK3R2 RBL2 PIK3R1 GNA12 RALGDS IGF1R GNA13 PIK3CA STAT1 GNAI1 MIR197 RPS6KA1 RAP1B RAP1A MAP2K3 GNAI3 PLCB1 MAPK14 CREB1 GNAS JUN STAT3 JAK2 MAPK3 JAK1 SCRIB KCNIP3 MIR937 OMEGA-3/OMEGA-6 FA SYNTHESIS%WIKIPATHWAYS_20200510%WP4723%HOMO SAPIENS Omega-3/Omega-6 FA synthesis ACSL3 MIR1908 PLA2G4B FADS2 PLA2G4A ACOT2 ACOX1 ACOX3 FADS1 PLA2G5 PLA2G6 ELOVL5 ACSL1 ELOVL2 ACSL4 TARGET OF RAPAMYCIN (TOR) SIGNALING%WIKIPATHWAYS_20200510%WP1471%HOMO SAPIENS Target Of Rapamycin (TOR) Signaling EIF4EBP1 PRR5 ULK2 PRR5L RPS6KB1 ULK1 HMGCR DDIT4L RRAGA RRAGC RRAGB RRAGD ULK3 RHEB PRKAG1 AKT1 PRKAG2 MIR6869 PRKAG3 RPTOR PRKCA PRKAB2 FKBP1A PRKAB1 CDC42 RAC1 MLST8 TSC2 TSC1 PRKAA1 AKT1S1 MAPKAP1 PRKAA2 RICTOR MTOR DDIT4 IDI1 PI3K-AKT-MTOR SIGNALING PATHWAY AND THERAPEUTIC OPPORTUNITIES%WIKIPATHWAYS_20200510%WP3844%HOMO SAPIENS PI3K-AKT-mTOR signaling pathway and therapeutic opportunities RB1CC1 EIF4EBP1 ULK1 TFEB GSK3B RHEB AKT1 PDK1 RPTOR PIK3R3 PIK3R2 PIK3CG PIK3R1 PTEN PIK3CB FOXO3 PIK3CA NRAS NOS3 HRAS GRB10 BAD KRAS TSC2 CDKN1B RICTOR ATG13 FOXO1 MTOR FOXO4 NUCLEAR RECEPTORS%WIKIPATHWAYS_20200510%WP170%HOMO SAPIENS Nuclear Receptors ESRRB ESR1 NR1D2 NR4A2 NR2F6 NR4A1 PPARG NR2F2 PPARA PPARD PGR NR2E1 HNF4A NR0B1 NR5A2 RARB NR1H2 RXRB NR1H3 THRA NR2F1 RARA NR2C2 ROR1 RXRG NR5A1 AR ESRRA VDR RORC RORA RARG NR3C1 THRB NR1I3 ESR2 NR1I2 MIR1469 RXRA NEOVASCULARISATION PROCESSES%WIKIPATHWAYS_20200510%WP4331%HOMO SAPIENS Neovascularisation processes RELB TGFB1 TGFB3 REL AKT1 NOTCH3 TGFBR1 NOTCH1 SMAD9 NOTCH4 SMAD5 FLT4 ACVRL1 DLL4 SMAD2 KIT CXCR4 MAPK9 SMAD1 MAPK8 JAG1 ANGPT1 MAPK1 PDGFB HIF1A KITLG MMP9 KDR SMAD3 EPHB2 TGFB2 CXCL12 NFKB2 RELA NFKB1 MAPK3 EPHB4 INTEGRATED BREAST CANCER PATHWAY%WIKIPATHWAYS_20200510%WP1984%HOMO SAPIENS Integrated Breast Cancer Pathway APOBEC3G FOSL1 AURKA ESR1 PIAS1 STK11 ZMIZ1 HDAC1 CDC25B CDK7 SMAD2 EGFR SMAD1 MAX CDC42 MAPK1 MIR1281 RASGRP3 CTNNB1 KRAS BMPR1A BARD1 BRCA1 BRCA2 TAB1 CSNK1D MSH6 PLK1 WEE1 HIPK2 CDK2 HMGCR NF1 MDM2 ATR ATM TGFBR1 TGFBR2 BCL2 ZNF655 SMAD6 IRS1 SMAD7 DHTKD1 PIK3R2 BMPR2 RALA STAT1 TFPI CERK XRCC3 AR JAKMIP1 TSC2 CYP19A1 TSC1 EDAR AHR FOXO1 JAK1 PAK1 CDH1 RB1 ARAF CASP9 CASP8 CCND1 CHEK2 CHEK1 ITPKC RHEB CASP3 ANXA1 AKT1 MAP3K13 MRE11A CDC25A GSK3A RAD50 RAD51 TP53 SMEK1 FAU NAB1 MMP1 ZMYND8 PLK3 SMEK2 MAP3K7CL BACH1 ALKBH1 RAC1 E2F1 MIR6125 PKIA RPP38 RALGAPA1 CCNB1IP1 BAK1 LGALS13 MYCBP2 BID PML PHB NUP85 TPR UBE2F GADD45A ERAL1 FER BAD ATF1 NOXA1 PIGR BRAF USP38 TRADD IMPA1 RASGEF1A ODC1 SMARCA4 CDK4 DCAKD USP15 BAX USP16 RAD54L USP21 FILIP1 SP1 MTOR FOSL2 NCOA3 GDI1 BLM MYC FADD PTEN MYT1 VEGFA RAP1A GRN SMAD4 RRAS CHUK CREB1 SIRT1 NFKB1 DAG1 EP300 ABL1 JUN RHO MSH2 MITOCHONDRIAL LC-FATTY ACID BETA-OXIDATION%WIKIPATHWAYS_20200510%WP368%HOMO SAPIENS Mitochondrial LC-Fatty Acid Beta-Oxidation ACSL3 ACADL CPT2 SLC25A20 ACADS HADHA SCP2 EHHADH CPT1A ACSF2 ACADM PECR ACSL1 HADH ACADVL ECI1 ACSL4 TRYPTOPHAN CATABOLISM LEADING TO NAD+ PRODUCTION%WIKIPATHWAYS_20200510%WP4210%HOMO SAPIENS Tryptophan catabolism leading to NAD+ production QPRT NADSYN1 HAAO NMNAT1 NAPRT NAMPT TDO2 KYNU AFMID NMNAT3 KMO NMNAT2 NMRK2 AADAT NMRK1 IDO1 SMALL CELL LUNG CANCER%WIKIPATHWAYS_20200510%WP4658%HOMO SAPIENS Small cell lung cancer ITGB1 ZBTB17 PIK3CD MAX AKT3 FN1 PTK2 LAMC1 CDKN1B CCNE1 CDKN2B CDK2 TRAF2 BCL2 NOS2 TRAF6 PIK3R3 PIK3R2 PIK3R1 PIK3CB PIK3CA CDKN1C LAMB2 ITGA3 COL4A1 RB1 CDKN1A CASP9 CASP8 CCND1 AKT2 BIRC7 CASP3 AKT1 POLK MIR4260 DDB2 RARB TP53 FHIT RXRB E2F1 E2F2 E2F3 BAK1 BID RXRG ITGA2B GADD45B GADD45A GADD45G CDK6 CDK4 BAX CYCS BCL2L1 CCNE2 COL4A2 COL4A4 COL4A3 COL4A6 APAF1 COL4A5 TRAF1 TRAF3 BIRC2 PTGS2 BIRC3 MYC LAMC3 LAMC2 NFKBIB ITGA2 PTEN BIRC8 CKS1B ITGA6 TRAF4 ITGAV CKS2 LAMA5 LAMA2 LAMA1 TRAF5 LAMA4 LAMA3 CHUK RELA LAMB3 NFKB1 LAMB4 IKBKB LAMB1 NFKBIA MIR4758 SKP1 RXRA IKBKG FTO OBESITY VARIANT MECHANISM%WIKIPATHWAYS_20200510%WP3407%HOMO SAPIENS FTO Obesity Variant Mechanism ARID5B FTO IRX5 IRX3 PPARGC1A TBX1 PRDM16 UCP1 SYNTHESIS AND DEGRADATION OF KETONE BODIES%WIKIPATHWAYS_20200510%WP311%HOMO SAPIENS Synthesis and Degradation of Ketone Bodies ACAT1 HMGCL BDH1 OXCT1 HMGCS2 MYOMETRIAL RELAXATION AND CONTRACTION PATHWAYS%WIKIPATHWAYS_20200510%WP289%HOMO SAPIENS Myometrial Relaxation and Contraction Pathways ACTA2 CAMK2B RYR2 CAMK2D CACNB3 CAMK2G YWHAG PLCD1 LPAR1 NOS3 RLN1 ACTC1 GSTO1 ATF5 ADCY2 GNG2 PRKCE GNB1 PRKD1 MYL2 DGKZ NOS1 CALCA ATP2A2 MYLK2 CNN1 RGS10 PRKAR1B PRKAR1A GNG13 PRKCH GNB5 MAFF RAMP1 ACKR3 PRKAR2B PRKAR2A SFN PRKCZ YWHAQ YWHAE YWHAB GNG11 YWHAH ADCY4 SLC8A1 ADCY3 RGS4 RGS5 RGS2 RGS3 ADCY7 PRKCG YWHAZ ACTA1 RGS1 PRKCB ADCY6 PRKCA ADCY5 ADCY9 RGS9 RGS6 RGS7 OXT GNGT1 PKIB ARRB1 ARRB2 PLCG2 PKIA GJA1 PKIG RYR1 PLCG1 ATP2A3 RYR3 RGS18 MIR4751 RGS17 RGS19 PRKCD RGS14 ATF1 ATF2 RGS20 ATF6B ITPR1 CRH PRKCQ ITPR2 ITPR3 FOS RGS11 RGS16 PDE4B SP1 CRHR1 PLCB3 GUCY1A3 PDE4D CREB3 GRK6 ATF4 IGFBP1 GNAQ GNB2 IGFBP3 IGFBP2 GNB4 GNB3 RXFP1 GRK5 GRK4 CAMK2A ETS2 ADCY1 OXTR GABPB1 ADCY8 ACTB GABPA ACTG1 ATF3 CRCP RXFP2 PRKACA IGFBP4 PRKACB MYL4 CNN2 GNG3 CALD1 GNG5 IGFBP6 GNG12 GNG4 GPR182 ADM GNG7 RAMP2 GNG8 CREB1 RAMP3 IGFBP5 CORIN GUCA2B NFKB1 GNAS GUCA2A CALM3 JUN CALM1 CALM2 IL6 IL1B TRANSCRIPTION CO-FACTORS SKI AND SKIL PROTEIN PARTNERS%WIKIPATHWAYS_20200510%WP4533%HOMO SAPIENS Transcription co-factors SKI and SKIL protein partners MECP2 NF1 TEAD1 TEAD2 MERTK TEAD3 TEAD4 LATS1 SKIL ING2 HDAC1 HDAC3 LATS2 PRMT5 SKI SIN3A SATB2 STK3 BIOGENIC AMINE SYNTHESIS%WIKIPATHWAYS_20200510%WP550%HOMO SAPIENS Biogenic Amine Synthesis TH MAOA AANAT MIR4761 PNMT TPH1 GAD1 ASMT CHAT DBH HDC COMT GAD2 DDC ACHE PAH AMYOTROPHIC LATERAL SCLEROSIS (ALS)%WIKIPATHWAYS_20200510%WP2447%HOMO SAPIENS Amyotrophic lateral sclerosis (ALS) MAP2K6 CASP9 DERL1 SLC1A2 PRPH CASP3 NEFL TNFRSF1A BCL2 NEFM NOS1 ALS2 TP53 GRIA1 RAC1 NEFH DAXX CCS CASP12 CST3 MAP2K2 BID MAP3K5 BAD TOMM40 GPX1 BAX MAPK14 PPP3CB TNF PPP3CC CASP1 SOD1 BCL2L1 CAT PPP3CA APAF1 RAB5A HUMAN COMPLEMENT SYSTEM%WIKIPATHWAYS_20200510%WP2806%HOMO SAPIENS Human Complement System ALB C5AR1 FPR1 FCN1 FCN2 F13A1 ELANE C4BPA VSIG4 CD93 FKBP2 SELL FCGR3A DCN FCER2 APCS CD59 CFHR2 CFHR4 CSNK1A1 SFTPA2 CLEC4M ICAM2 ITGAX LAMC1 C1QBP MBL2 THBS1 CPN1 PROS1 CR2 CR1 CFD PLAUR C1S C1R SERPING1 CFP CD46 C8A CFH C2 CFI C3 C4A ADIPOQ C6 ICAM1 F10 TXN C7 F12 C9 GNA15 MASP2 MASP1 KLKB1 RPS19 CFB CD55 TLR2 ITGB2 SELPLG C5 SELE SELP CRP PLG CD19 FGB FGA CALR FGG PRKCA CD40 F11 ARRB2 ITGA2B IBSP GNAI2 VTN APOA1 PRNP ITGA2 SPP1 ITGB3 MIR197 LAMA5 C3AR1 PRKACA GNAI3 LRP2 WAS ADM C5AR2 PTX3 SFTPA1 LAMB1 MIR4758 MELATONIN METABOLISM AND EFFECTS%WIKIPATHWAYS_20200510%WP3298%HOMO SAPIENS Melatonin metabolism and effects CLOCK AANAT GSK3B CYP1A2 PRKCA TRAF6 ADRB1 CSNK1E CRY2 CAMK2A ECE1 CRY1 ARNTL IRAK1 MTNR1A MAOA CYP2C19 MTNR1B SULT1A1 EDN1 APOE MIR718 MIR146A PER2 PER1 PER3 ASMT CYP2D6 MIR126 MAP2 SIRT1 CYP1B1 MIR6883 NFKB1 CALM3 CYP1A1 CALM1 CALM2 FOXO1 CSNK1D ACHE NAD+ METABOLISM%WIKIPATHWAYS_20200510%WP3644%HOMO SAPIENS NAD+ metabolism SIRT6 SIRT4 SIRT5 SIRT7 PARP1 NRK SIRT2 NT5E NMNAT1 NADK CD38 NAMPT SIRT1 NMNAT3 SIRT3 NMNAT2 APOPTOSIS-RELATED NETWORK DUE TO ALTERED NOTCH3 IN OVARIAN CANCER%WIKIPATHWAYS_20200510%WP2864%HOMO SAPIENS Apoptosis-related network due to altered Notch3 in ovarian cancer CDKN1A CUL5 PAK2 AKT1 HDAC1 AXIN1 CUL1 HSPD1 MAPK1 VIM PKN1 PTK2 NRG1 NQO1 ERN1 ANXA5 NGFRAP1 YBX3 CASP7 CARD14 PTK2B RNF7 NET1 SQSTM1 SERBP1 IL7R CDKN1B HELLS ETS1 TRAF1 ERBB3 VAV3 JUND RPS6KB1 TNFRSF21 THBS1 GCLC IER3 TNFRSF10B SMAD7 RIPK2 HSPA5 HSPB1 BIRC5 F2R APOE MIR8085 BCL3 TNF APP NFKB1 ABL1 SOCS3 CTNNA1 BMP2-WNT4-FOXO1 PATHWAY IN HUMAN PRIMARY ENDOMETRIAL STROMAL CELL DIFFERENTIATION%WIKIPATHWAYS_20200510%WP3876%HOMO SAPIENS BMP2-WNT4-FOXO1 Pathway in Human Primary Endometrial Stromal Cell Differentiation SFRP1 LEFTY2 BMP2 CTNNB1 BCL2L11 SMAD9 SST SMAD5 DCN WNT4 FOXO1 SMAD1 DKK1 MAP3K1 ROLE IN PROMOTING AND BLOCKING GONADAL DETERMINATION%WIKIPATHWAYS_20200510%WP4872%HOMO SAPIENS MAP3K1 role in promoting and blocking gonadal determination MAPK1 SOX9 FOXL2 CTNNB1 GSK3B MAP3K4 MAPK11 FRAT1 MAP3K1 RHOA GADD45G AXIN1 FGF9 WNT4 ROCK1 FGFR2 SRY INFLAMMATORY RESPONSE PATHWAY%WIKIPATHWAYS_20200510%WP453%HOMO SAPIENS Inflammatory Response Pathway MIR7846 VTN IL2 LCK THBS1 IL4R TNFRSF1A COL1A2 CD86 CD80 LAMC2 IL4 CD40 IL5RA CD28 ZAP70 LAMA5 FN1 LAMB2 IFNG COL1A1 THBS3 COL3A1 CD40LG IL5 IL2RG LAMC1 IL2RA LAMB1 MIR4758 IL2RB TNFRSF1B SEROTONIN RECEPTOR 2 AND ELK-SRF/GATA4 SIGNALING%WIKIPATHWAYS_20200510%WP732%HOMO SAPIENS Serotonin Receptor 2 and ELK-SRF/GATA4 signaling ELK1 MAPK1 HRAS MAP2K1 MAP2K2 RASGRF1 RASGRP1 GNAQ KRAS HTR2C HTR2A ITPR1 RAF1 SRF ELK4 MAPK3 GATA4 MAPKAPK2 HTR2B NRAS POLYOL PATHWAY%WIKIPATHWAYS_20200510%WP690%HOMO SAPIENS Polyol Pathway ALDOB AKR1B1 SORD KHK HEDGEHOG SIGNALING PATHWAY%WIKIPATHWAYS_20200510%WP4249%HOMO SAPIENS Hedgehog Signaling Pathway DHH SPOP CSNK1G3 PTCH2 FBXL17 SPOPL CSNK1G2 SMO CCND1 EVC GPR161 CSNK1G1 CCND2 BCL2 CUL3 EVC2 CDON SMURF1 BOC CSNK1E ARRB1 ARRB2 IHH SMURF2 CSNK1A1 GLI1 KIF7 PRKACG CSNK1A1L LRP2 PRKACA PRKACB ADRBK1 PTCH1 SHH GLI3 GLI2 SUFU CSNK1D ADRBK2 GAS1 HHIP KIF3A OXIDATION BY CYTOCHROME P450%WIKIPATHWAYS_20200510%WP43%HOMO SAPIENS Oxidation by Cytochrome P450 CYP2S1 CYP4A11 CYP4F2 CYP4B1 CYP8B1 CYP2C9 CYP24A1 CYP1A2 CYP2E1 CYP17A1 CYP26C1 CYP4Z1 CYP39A1 CYP2U1 CYP4F22 CYP4X1 CYP3A4 CYP3A5 CYP4F3 CYP4F8 CYP4F11 CYP27C1 CYP2D6 CYP4V2 CYP3A43 CYP26A1 CYP1A1 CYP11A1 CYP11B2 CYP2A7 CYP46A1 CYP3A7 CYB5A POR CYP4F12 CYB5R2 MIR4651 CYB5R1 CYP7B1 CYB5R4 CYB5R3 CYB5B CYP2W1 CYP11B1 CYP2G1P CYP20A1 CYP51A1 CYP27A1 CYP2C19 CYP2R1 CYP2A6 CYP19A1 CYP2C18 CYP2A13 CYP2C8 CYP1B1 CYP2F1 CYP26B1 CYP2J2 CYP4A22 CYP7A1 CYP27B1 CYP2B6 HOST-PATHOGEN INTERACTION OF HUMAN CORONA VIRUSES - MAPK SIGNALING%WIKIPATHWAYS_20200510%WP4877%HOMO SAPIENS Host-pathogen interaction of human corona viruses - MAPK signaling MAP2K6 MAP2K7 IFITM1 MAP3K10 BCL2 MAP3K11 IFITM3 IFITM2 IFI27 MAPK9 RPS6KA3 MAPK8 MAPK1 RPS6KA2 MAP2K1 RPS6KA1 MAP2K2 MAP3K9 MAPK12 MAPK13 DDIT3 JUNB MAP3K4 MAP2K3 MAPK10 MAP2K4 MAPK11 ATF2 MAP3K1 RAF1 FOS MAPK14 EIF4E JUN BST2 MAPK3 GLYCOLYSIS AND GLUCONEOGENESIS%WIKIPATHWAYS_20200510%WP534%HOMO SAPIENS Glycolysis and Gluconeogenesis PFKL GOT2 PFKP PFKM DLAT SLC2A3 PC SLC2A1 GCK GPI HK2 HK3 LDHA PKM TPI1 SLC2A2 ENO2 PGAM2 ENO3 PGK1 ENO1 MPC1 ALDOA MPC2 GAPDH HK1 FBP2 LDHAL6B DLD SLC2A4 PGAM1 G6PC ALDOC SLC2A5 ALDOB PCK1 LDHC FBP1 LDHB PGK2 PDHA1 MDH1 GOT1 PKLR MDH2 FOLLICLE STIMULATING HORMONE (FSH) SIGNALING PATHWAY%WIKIPATHWAYS_20200510%WP2035%HOMO SAPIENS Follicle Stimulating Hormone (FSH) signaling pathway GRK6 EIF4EBP1 RPS6 RPS6KB1 RPS6KB2 FSHR RHEB AKT1 PRKCA APPL1 SRC AREG MAPK1 FSHB SGK1 PRKACA CYP19A1 TSC2 BDNF RAF1 CGA MAPK14 CREB1 MAPK3 FOXO1 MTOR HIST3H3 METABOLIC REPROGRAMMING IN COLON CANCER%WIKIPATHWAYS_20200510%WP4290%HOMO SAPIENS Metabolic reprogramming in colon cancer PFKL PSAT1 GOT2 SDHB PYCR1 IDH3A PDHB PAICS ACO2 RPIA FH GLS TALDO1 DLST G6PD PGD SLC2A1 SUCLG2 TKT PPAT GART TIGAR GPI HK3 LDHA PKM PGK1 ENO1 ACLY GAPDH FASN PSPH MIR6787 MIR6741 PGAM1 SLC16A3 SLC1A5 PYCR2 IDH2 ALDOB SHMT2 GLUD1 PDHA1 MDH2 NEURAL CREST CELL MIGRATION DURING DEVELOPMENT%WIKIPATHWAYS_20200510%WP4564%HOMO SAPIENS Neural Crest Cell Migration during Development PAK7 EPHB3 PIK3R6 PAK6 MMP8 F2RL2 CDH11 PAK3 NGEF PAK2 AKT2 PAK4 AKT1 MIR3620 ARF1 PIK3R3 PIK3CG PIK3CD PIK3CB PIK3CA RAC1 AKT3 MMP9 PIK3R5 MMP2 TRIO RHOA EPHB2 TIAM1 BDNF FOS PIK3R4 JUN STAT3 EPHB6 PAK1 TWIST1 NGFR EPHB1 EPHB4 STRIATED MUSCLE CONTRACTION PATHWAY%WIKIPATHWAYS_20200510%WP383%HOMO SAPIENS Striated Muscle Contraction Pathway DES MYH8 MYH6 TCAP DMD TNNT2 TNNI3 ACTN4 ACTA2 MYL2 ACTA1 MYL9 TMOD1 ACTN2 TNNC1 ACTG1 TPM3 VIM NEB TPM1 MYL1 MYL4 MYOM1 TTN MYL3 TNNI1 TNNI2 MYBPC3 MYBPC1 ACTC1 MYBPC2 TPM4 TPM2 TNNC2 MYH3 ACTN3 TNNT1 TNNT3 CANCER IMMUNOTHERAPY BY PD-1 BLOCKADE%WIKIPATHWAYS_20200510%WP4585%HOMO SAPIENS Cancer immunotherapy by PD-1 blockade NFATC4 HLA-DRB1 ZAP70 HLA-A CD8B CD274 CD8A PDCD1 CD3D IFNG LCK NFATC3 NFAT5 NFATC1 PDCD1LG2 PTPN11 NFKB1 JUN STAT3 CD3G NFATC2 BATF CD3E CANNABINOID RECEPTOR SIGNALING%WIKIPATHWAYS_20200510%WP3869%HOMO SAPIENS Cannabinoid receptor signaling CYP2C9 ADCY7 FAAH NAPEPLD DAGLB ADORA2A MAPK9 ADCY1 MAPK8 CYP3A4 MAPK1 CNR2 CYP2C19 CNR1 MAPK12 PRKAR1B MAPK13 PRKAR1A PRKACG MAPK10 DAGLA PRKACA MAPK11 PRKACB PRKAR2B MAPK14 AHR CYP1A1 MAPK3 IL-1 SIGNALING PATHWAY%WIKIPATHWAYS_20200510%WP195%HOMO SAPIENS IL-1 signaling pathway MAP2K6 MAP2K7 IRAK2 REL AKT1 IRAK4 MAP3K14 HSPB2 MAPKAPK2 MAPK9 MAPK8 MAPK1 MAP2K1 MAP2K2 PELI1 PLCG1 IL1RAP PELI2 TOLLIP TAB3 ATF2 SQSTM1 TAB2 TAB1 MAP3K2 MAP3K3 TRAF6 MAP3K7 NFKBIB PTPN11 PIK3R2 PIK3R1 IL1R1 IRAK1 MIR6502 IRAK3 CCL2 MIR718 MAP2K3 MAP2K4 MAP3K1 UBE2N MYD88 CHUK UBE2V1 ECSIT MAPK14 RELA NFKB1 IKBKB JUN NFKBIA PRKCZ MAPK3 IL1A IKBKG IL1B MITOCHONDRIAL COMPLEX I ASSEMBLY MODEL OXPHOS SYSTEM%WIKIPATHWAYS_20200510%WP4324%HOMO SAPIENS Mitochondrial complex I assembly model OXPHOS system NUBPL TMEM261 TMEM186 ATP5SL ACAD9 TMEM126B NDUFAF7 FOXRED1 TMEM70 COA1 TIMMDC1 NDUFAF6 NDUFAF4 NDUFAF2 NDUFAF3 NDUFAF1 MT-ND6 MT-ND4L MT-ND4 MT-ND5 NDUFA10 MT-ND2 NDUFA12 MT-ND1 NDUFB11 NDUFC2 NDUFC1 NDUFS6 NDUFS5 NDUFS4 NDUFS3 NDUFS2 NDUFA13 NDUFS1 NDUFB9 NDUFB8 NDUFB7 NDUFB10 NDUFB6 NDUFB5 NDUFB4 NDUFB2 NDUFB1 NDUFB3 NDUFA1 NDUFV3 NDUFV2 NDUFV1 NDUFA8 NDUFA7 NDUFA6 NDUFA5 NDUFA2 NDUFAB1 ECSIT EGF/EGFR SIGNALING PATHWAY%WIKIPATHWAYS_20200510%WP437%HOMO SAPIENS EGF/EGFR Signaling Pathway BCAR1 AURKA MYBL2 GAB2 DOK2 AP2A1 INPP5D DNM1 SRC PLCE1 AP2S1 EGFR MAPK9 AP2B1 CDC42 MAPK8 RIN1 MAPK1 NOS3 LIMK2 ITCH HRAS MAP2K1 MAP2K2 PLD2 PTK2 RALB KRAS GRB2 SOS1 RAF1 ERRFI1 PIK3C2B RICTOR HGS RAB5A TWIST1 FOXO4 VAV3 SPRY2 EPS15 NDUFA13 NEDD4 PLD1 RASA1 ARHGEF1 INPPL1 PTPN11 CBLC PIK3R2 PTK6 PIK3R1 RALA CBLB RALGDS STAT1 RPS6KA3 NCK2 RPS6KA5 NCK1 RPS6KA2 RPS6KA1 PTPN5 GRB10 CAV2 TNK2 CAV1 MAP3K4 MT-CO2 SHC1 STXBP1 STAT3 PRKCZ FOXO1 JAK1 PAK1 CFL1 EIF4EBP1 MAP2K5 USP8 AKT1 PRKCB PRKCA SOS2 PIAS3 ERBB2 RAC1 E2F1 ELK1 MAP4K1 GJA1 PDPK1 PLCG1 GAB1 STAT5A STAT5B PRKCI PRKCD SYNJ1 ATF1 CRK EGF BRAF ARF6 RALBP1 CBL PTK2B FOS MAPK7 SP1 USP6NL MAPK4 SH3GL2 STAMBP STAM2 MAP3K2 IQSEC1 MAP3K3 MTOR IQGAP1 SH3KBP1 EPS15L1 PLSCR1 JUND PXDN NEDD8 RPS6KB1 SH2D2A ASAP1 MEF2D REPS2 PTPN12 ABI1 MEF2A NCOA3 EPS8 PEBP1 FOSB ATXN2 MEF2C PTEN CAMK2A STMN1 EPN1 VAV1 VAV2 MIR3917 RAP1A MAP3K1 PCNA PTPRR CRKL MAPK14 CREB1 CSK SH3GL3 ROCK1 ABL1 JUN AP2M1 ELK4 JAK2 STAM GENE REGULATORY NETWORK MODELLING SOMITOGENESIS %WIKIPATHWAYS_20200510%WP2854%HOMO SAPIENS Gene regulatory network modelling somitogenesis TBX6 LFNG DLL1 FGF8 EPHA4 HES7 MESP2 WNT3A RIPPLY2 NOTCH1 HES1 DIFFERENTIATION PATHWAY%WIKIPATHWAYS_20200510%WP2848%HOMO SAPIENS Differentiation Pathway ALK TGFB1 NTF4 TGFB3 FST NOG IL11 EPO TNFSF11 LEFTY1 WNT2B IL3 NOTCH1 FGF1 CXCR1 FGF4 INHBA GDF5 BMP4 TF KIT WNT5A DKK1 CNTF PDGFB IGF1 VEGFA KITLG WNT7B FGF2 PDGFA NT5E INS EGF CSF1 IL6R NODAL FLT3LG WNT1 WNT2 HGF SHH TPO FGF8 IL6 WNT3A FGF10 CSF1R PYRIMIDINE METABOLISM%WIKIPATHWAYS_20200510%WP4022%HOMO SAPIENS Pyrimidine metabolism POLR2A POLR2B POLR2C POLE4 POLR2E POLR2G POLE2 POLR2H POLR2I POLE3 POLR2J POLR2K RRM2B POLR3B POLR1A POLR3D POLR1B POLR3E POLR1D POLR1E POLR3H POLR3K ENPP3 NME7 PRIM2 PRIM1 RRM1 POLR1C RRM2 POLR2L DPYS POLA1 UPB1 POLR3GL POLA2 TYMP DHODH NT5C POLR3A DPYD POLR3C TK2 POLR3F UMPS POLR3G DCK NME1 ZNRD1 ENTPD1 ENTPD3 NME2 CDA CTPS2 NME3 CTPS1 TK1 NME4 UPP1 DCTD NME6 TYMS CMPK1 CMPK2 UCK2 UPRT NME1-NME2 UCK1 DCTPP1 DTYMK ENPP1 POLR2D CAD TWISTNB NT5M POLR2J3 DUT POLR2J2 PNPT1 MIR1914 UCKL1 POLD3 POLD4 POLD1 POLD2 POLE WHITE FAT CELL DIFFERENTIATION%WIKIPATHWAYS_20200510%WP4149%HOMO SAPIENS White fat cell differentiation IRF3 MECOM TLE3 PPARG NR2F2 ZNF423 EGR2 CEBPA CEBPB SREBF1 GATA3 EBF1 NR1H3 IRF4 TCF7L1 RARA STAT5A STAT5B DDIT3 KLF15 INS KLF5 CEBPD GATA2 RORA NR3C1 CREB1 WNT10B KLF2 MIR1469 FOXO1 KLF4 CTNNA1 INTEGRATED CANCER PATHWAY%WIKIPATHWAYS_20200510%WP1971%HOMO SAPIENS Integrated Cancer Pathway RB1 CDKN2B CDKN1A CDK1 CDK2 CASP9 MDM2 CASP8 ATR CHEK2 CHEK1 ATM CASP3 POU2F1 AKT1 MIR3191 BLM MIR3190 BCL2 MRE11A MYC CDC25A RAD50 CDC25B TP53 SMAD2 PTEN MMP1 STAT1 BACH1 E2F1 MAP3K5 BAD ATF1 NOXA1 SMAD3 BBC3 CDK4 BAX CDKN1B BARD1 BRCA1 JAK1 PLK1 MSH6 MSH2 EPO RECEPTOR SIGNALING%WIKIPATHWAYS_20200510%WP581%HOMO SAPIENS EPO Receptor Signaling EPO AKT1 PTPRU PDK1 RASA1 IRS1 SRC PIK3CG IRS2 STAT1 MAPK1 MAP2K1 MAP2K2 STAT5A STAT5B GRB2 SOS1 PTPRC RAF1 SHC1 EPOR STAT3 JAK2 MAPK3 SOCS1 CISH B CELL RECEPTOR SIGNALING PATHWAY%WIKIPATHWAYS_20200510%WP23%HOMO SAPIENS B Cell Receptor Signaling Pathway MAP2K6 HCLS1 LCK REL GSK3B GTF2I PIP5K1B GAB2 ILF2 DAPP1 CD79B CD79A INPP5D CD22 MIR5196 BLNK LAT2 SH3BP2 PTPN18 BTK MAPK9 MAX CDC42 MAPK8 MAPK1 HRAS MAP2K1 MAP2K2 RASGRP3 GRB2 SOS1 RAF1 CR2 PIP5K1C PTPN11 PIK3R2 PIK3R1 PTPN6 NCK1 BLK RPS6KA1 SHC1 FOXO1 NFATC2 CD19 AKT1 PRKCB GSK3A PIK3CG SYK RAC2 RAC1 ELK1 PLCG2 MAP4K1 E2F3 PDPK1 PLCG1 GAB1 KLF11 RAPGEF1 PRKCD CARD11 CRK ATF2 BCL10 BRAF MALT1 PTPRC CBL PIP5K1A MAPK4 ETS1 MEF2D MYC FYN MAP3K7 MEF2C CD81 LYN CAMK2A IRF4 TEC VAV1 VAV2 BCL6 NFATC3 CHUK CRKL MAPK14 CREB1 RELA NFKB1 IKBKB JUN NFKBIA PIK3AP1 IKBKG INTERLEUKIN-1 INDUCED ACTIVATION OF NF-KAPPA-B%WIKIPATHWAYS_20200510%WP3656%HOMO SAPIENS Interleukin-1 Induced Activation of NF-kappa-B UBE2V1 TRAF6 IRAK1 SQSTM1 NFKB1 MIR718 TIFA PRKCZ IL1A UBE2N AJUBA IL-9 SIGNALING PATHWAY%WIKIPATHWAYS_20200510%WP22%HOMO SAPIENS IL-9 Signaling Pathway CDK9 MAPK1 MIR3960 MAP2K1 MAP2K2 IL9 STAT5A STAT5B IL9R JAK3 GRB2 IL2RG PIK3R2 PIK3R1 STAT3 MAPK3 JAK1 STAT1 PYRIMIDINE METABOLISM AND RELATED DISEASES%WIKIPATHWAYS_20200510%WP4225%HOMO SAPIENS Pyrimidine metabolism and related diseases TYMS TYMP DHODH NT5C3A NT5C DPYD TK2 UMPS CAD CPS1 GLS2 OTC RRM2B RRM1 RRM2 DPYS UPB1 PLATELET-MEDIATED INTERACTIONS WITH VASCULAR AND CIRCULATING CELLS%WIKIPATHWAYS_20200510%WP4462%HOMO SAPIENS Platelet-mediated interactions with vascular and circulating cells ICAM1 SELP TGFB1 PF4 TGFB3 CCL2 TLR7 TLR2 CD40LG TGFB2 CCL5 TLR4 VCAM1 SELPLG CD40 SELE IL1B MRNA PROCESSING%WIKIPATHWAYS_20200510%WP411%HOMO SAPIENS mRNA Processing POLR2A HNRNPK MIR7-1 HNRNPR SNRPD2 DICER1 MIR1234 SNRPD1 CLP1 PAPOLA SNRPD3 TXNL4A PSKH1 PRPF4B CDC40 SRRM1 PRPF4 PRPF6 PRPF3 XRN2 SNRPG SRSF2 SRSF3 PTBP1 SNRPE SRSF4 MIR4745 SNRPF SREK1 SNRPB2 METTL3 SRSF5 SRSF6 RNGTT SRSF7 SNRPA SNRPB SRSF9 CLK2 RNU2-1 SPOP TMED10 DHX8 CSTF3 CSTF2 DHX9 PRPF8 CSTF1 PRMT2 DHX38 SRPK2 CPSF4 CPSF1 CPSF3 CPSF2 CLK4 CLK3 LSM2 HNRNPD CLK1 HNRNPL HNRNPM LSM7 RNPS1 HNRNPC CLASRP SUGP2 SUGP1 CELF2 CELF4 MIR6849 SNRNP70 DHX15 DHX16 RBM5 RBM17 SF3A3 NCBP1 NCBP2 PRPF40A MIR636 PRPF18 NHP2L1 SNRPA1 HNRNPH2 DNAJC8 HNRNPAB SF3B4 SF3B5 SF3B2 SF3B3 SFSWAP RNMT SRSF1 CSTF2T U2AF1 NXF1 PABPN1 U2AF2 TRA2B HNRNPA1 SRSF10 SF3B1 SF3A1 SF3A2 MIR939 NUDT21 SNRNP40 SUPT5H PHF5A HNRNPA2B1 RBMX YBX1 NONO PCBP2 SRP54 SFPQ SNRPN PTBP2 DDX20 PPM1G CD2BP2 SRPK1 HNRNPU DDX1 HNRNPH1 CELF1 RBM39 FUS SMC1A PRMT1 EFTUD2 OVERVIEW OF INTERFERONS-MEDIATED SIGNALING PATHWAY%WIKIPATHWAYS_20200510%WP4558%HOMO SAPIENS Overview of interferons-mediated signaling pathway IFNA21 TYK2 IFNA5 IFNA4 IFNGR1 IFNA7 IFNGR2 IFNA6 PRKCA IFNA1 IFNA2 IFNA8 PIK3R1 IFNL2 IFNL1 IFNLR1 IFNL4 IFNL3 PIK3CA STAT1 IFNW1 IFNB1 IFNAR2 STAT2 IFNG IRF9 IFNAR1 IL10RB IFNA13 IFNA14 IFNA16 IFNA17 JAK2 JAK1 IFNE IFNA10 IFNK SECRETION OF HYDROCHLORIC ACID IN PARIETAL CELLS%WIKIPATHWAYS_20200510%WP2597%HOMO SAPIENS Secretion of Hydrochloric Acid in Parietal Cells ATP4A CCKBR GAST CHRM1 HRH2