THIO-MOLYBDENUM COFACTOR BIOSYNTHESIS%HUMANCYC%PWY-5963 thio-molybdenum cofactor biosynthesis Mocos PROLINE BIOSYNTHESIS I%HUMANCYC%PROSYN-PWY proline biosynthesis I Pycr2 Pycrl Pycr1 Aldh18a1 MOLYBDENUM COFACTOR BIOSYNTHESIS%HUMANCYC%PWY-6823 molybdenum cofactor biosynthesis Nfs1 Mocs3 LOC100911034 GLYCEROL DEGRADATION I%HUMANCYC%PWY-4261 glycerol degradation I Gk Gk2 OXIDATIVE ETHANOL DEGRADATION III%HUMANCYC%PWY66-161 oxidative ethanol degradation III Aldh2 Acss2 Acss3 Cyp2e1 Acss1 Aldh3a2 TETRAPYRROLE BIOSYNTHESIS II%HUMANCYC%PWY-5189 tetrapyrrole biosynthesis II Alad Uros Hmbs Alas2 ASPARAGINE DEGRADATION I%HUMANCYC%ASPARAGINE-DEG1-PWY asparagine degradation I Asrgl1 Aspg TETRAHYDROBIOPTERIN BIOSYNTHESIS I%HUMANCYC%PWY-5663 tetrahydrobiopterin biosynthesis I Spr Pts Gch1 UREA CYCLE%HUMANCYC%PWY-4984 urea cycle Asl Cps1 Ass1 Arg1 Otc 4-HYDROXYPHENYLPYRUVATE BIOSYNTHESIS%HUMANCYC%PWY-5886 4-hydroxyphenylpyruvate biosynthesis Tat KETOGENESIS%HUMANCYC%REACT_1464.NULL ketogenesis Hadhb Bdh1 Hmgcs2 Hmgcl Acat1 CDP-DIACYLGLYCEROL BIOSYNTHESIS I%HUMANCYC%PWY-5667 CDP-diacylglycerol biosynthesis I Abhd5 Agpat2 Gpat2 Agpat9 Lclat1 Agpat5 Cds2 Agpat6 Agpat3 Agpat4 Agpat1 Gpam Gpd2 Lpcat4 Cds1 Lpcat3 SELENOCYSTEINE BIOSYNTHESIS II (ARCHAEA AND EUKARYOTES)%HUMANCYC%PWY-6281 selenocysteine biosynthesis II (archaea and eukaryotes) Sephs1 Sars2 Sars CATECHOLAMINE BIOSYNTHESIS%HUMANCYC%PWY66-301 catecholamine biosynthesis Ddc RAPOPORT-LUEBERING GLYCOLYTIC SHUNT%HUMANCYC%PWY-6405 Rapoport-Luebering glycolytic shunt Pgam2 Bpgm L-CARNITINE BIOSYNTHESIS%HUMANCYC%PWY-6100 L-carnitine biosynthesis Tmlhe Aldh9a1 Bbox1 ASPARAGINE BIOSYNTHESIS I%HUMANCYC%ASPARAGINE-BIOSYNTHESIS asparagine biosynthesis I Asns UDP-D-XYLOSE AND UDP-D-GLUCURONATE BIOSYNTHESIS%HUMANCYC%PWY-4821 UDP-D-xylose and UDP-D-glucuronate biosynthesis Uxs1 Ugdh 4-HYDROXY-2-NONENAL DETOXIFICATION%HUMANCYC%PWY-7112 4-hydroxy-2-nonenal detoxification Gsta5 Gsta1 Gstp1 GDP-MANNOSE BIOSYNTHESIS%HUMANCYC%PWY-5659 GDP-mannose biosynthesis Gpi Mpi Gmppb Gmppa Pmm1 Pmm2 GUANINE AND GUANOSINE SALVAGE I%HUMANCYC%PWY-6620 guanine and guanosine salvage I Pnp THREONINE DEGRADATION II%HUMANCYC%THREONINE-DEG2-PWY threonine degradation II Gcat SUPERPATHWAY OF D-MYO< I>-INOSITOL (1,4,5)-TRISPHOSPHATE METABOLISM%HUMANCYC%PWY-6358 superpathway of D-myo< i>-inositol (1,4,5)-trisphosphate metabolism Pten Synj2 Impad1 NEWGENE_1306455 Inpp1 Inpp5k LOC100910881 Inpp5a Synj1 Itpka Impa2 Itpkc Inpp5d Impa1 Itpkb Inpp5f Ocrl Ipmk S-ADENOSYL-L-METHIONINE BIOSYNTHESIS%HUMANCYC%SAM-PWY S-adenosyl-L-methionine biosynthesis Mat1a LOC100363915 Mat2a D-MYO< I>-INOSITOL (1,4,5)-TRISPHOSPHATE DEGRADATION%HUMANCYC%PWY-6363 D-myo< i>-inositol (1,4,5)-trisphosphate degradation NEWGENE_1306455 Inpp1 Inpp5k LOC100910881 Inpp5a Synj1 Impa2 Impa1 Inpp5f Ocrl Synj2 Impad1 MAP KINASE CASCADE%HUMANCYC%REACT_634.NULL MAP kinase cascade Ywhab GUANOSINE NUCLEOTIDES DEGRADATION III%HUMANCYC%PWY-6608 guanosine nucleotides degradation III Xdh Pnp Gda ASPARTATE BIOSYNTHESIS%HUMANCYC%ASPARTATESYN-PWY aspartate biosynthesis Got1 Got1l1 Got2 XANTHINE AND XANTHOSINE SALVAGE%HUMANCYC%SALVPURINE2-PWY xanthine and xanthosine salvage Pnp GLYCINE BIOSYNTHESIS I%HUMANCYC%GLYSYN-PWY glycine biosynthesis I Shmt1 Shmt2 GALACTOSE DEGRADATION I (LELOIR PATHWAY)%HUMANCYC%PWY-6317 galactose degradation I (Leloir pathway) Gale Galt Galm Galk1 BMP SIGNALLING PATHWAY%HUMANCYC%REACT_12034.NULL BMP Signalling Pathway Ube2d1 Ube2d3 Bmp2 GDP-GLUCOSE BIOSYNTHESIS%HUMANCYC%PWY-5661 GDP-glucose biosynthesis Pgm5 Pgm1 Pgm2 DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE BIOSYNTHESIS%HUMANCYC%MANNOSYL-CHITO-DOLICHOL-BIOSYNTHESIS dolichyl-diphosphooligosaccharide biosynthesis LOC100910177 Alg6 Dpagt1 Alg8 Dpm3 Alg1 Dpm1 Alg3 GLUTATHIONE BIOSYNTHESIS%HUMANCYC%GLUTATHIONESYN-PWY glutathione biosynthesis Gclc Gss Gclm SUPEROXIDE RADICALS DEGRADATION%HUMANCYC%DETOX1-PWY superoxide radicals degradation Sod3 Cat Tyrp1 Sod1 Sod2 MYO< I>-INOSITOL BIOSYNTHESIS%HUMANCYC%PWY-2301 myo< i>-inositol biosynthesis NEWGENE_1306455 Isyna1 LOC100910881 Impa2 Impa1 Impad1 GLYCINE BIOSYNTHESIS III%HUMANCYC%GLYSYN-ALA-PWY glycine biosynthesis III Agxt Agxt2 PYRIDOXAL 5'-PHOSPHATE SALVAGE PATHWAY%HUMANCYC%PLPSAL-PWY pyridoxal 5'-phosphate salvage pathway ARGININE DEGRADATION VI (ARGINASE 2 PATHWAY)%HUMANCYC%ARG-PRO-PWY arginine degradation VI (arginase 2 pathway) Arg1 Pycr2 Pycrl Pycr1 Oat CITRULLINE-NITRIC OXIDE CYCLE%HUMANCYC%PWY-4983 citrulline-nitric oxide cycle Asl Nos1 LOC497963 Ass1 Nos3 PHOSPHATIDYLGLYCEROL BIOSYNTHESIS II (NON-PLASTIDIC)%HUMANCYC%PWY4FS-8 phosphatidylglycerol biosynthesis II (non-plastidic) Abhd5 Agpat2 Gpat2 Agpat9 Lclat1 Agpat5 Cds2 Agpat6 Agpat3 Agpat4 Agpat1 Pgs1 Gpam Gpd2 Lpcat4 Cds1 Lpcat3 L-DOPA DEGRADATION%HUMANCYC%PWY-6334 L-dopa degradation Comt SALVAGE PATHWAYS OF PYRIMIDINE RIBONUCLEOTIDES%HUMANCYC%PWY0-163 salvage pathways of pyrimidine ribonucleotides Cda Nme3 Uprt Uck2 Nme7 Nme6 Upp1 Nme1 Uckl1 Upp2 Decr2 LOC100909857 Uck1 aicda SULFATE ACTIVATION FOR SULFONATION%HUMANCYC%PWY-5340 sulfate activation for sulfonation Papss2 TYROSINE DEGRADATION I%HUMANCYC%TYRFUMCAT-PWY tyrosine degradation I Tat Hgd Fah Hpd SPERMINE BIOSYNTHESIS%HUMANCYC%ARGSPECAT-PWY spermine biosynthesis Amd1 PURINE NUCLEOTIDES DE NOVO< I> BIOSYNTHESIS II%HUMANCYC%PWY-841 purine nucleotides de novo< i> biosynthesis II Impdh2 LOC100912917 Gart Adsl Paics Adss Gmps Atic Pfas Impdh1 Ppat GLUTAMINE DEGRADATION I%HUMANCYC%GLUTAMINDEG-PWY glutamine degradation I Gls2 Asns SEROTONIN DEGRADATION%HUMANCYC%PWY-6313 serotonin degradation Sult1a1 Aldh2 Adh6 Maob Maoa Aldh3a2 RGD1559459 Ugt2b17 EUMELANIN BIOSYNTHESIS%HUMANCYC%PWY-6498 eumelanin biosynthesis Tyrp1 Tyr COLANIC ACID BUILDING BLOCKS BIOSYNTHESIS%HUMANCYC%COLANSYN-PWY colanic acid building blocks biosynthesis Ugp2 Tsta3 Ugdh Gmds Gale Galt Gpi Galk1 Mpi Gmppb Gmppa Pmm1 Pmm2 D-MANNOSE DEGRADATION%HUMANCYC%MANNCAT-PWY D-mannose degradation Mpi GLUCONEOGENESIS I%HUMANCYC%GLUCONEO-PWY gluconeogenesis I Gapdhs Pck1 Aldob Pgk2 Mdh1 LOC100911625 Aldoa Fbp2 Pgk1 Mdh2 Eno1 Me1 Me3 Pgam2 Me2 Bpgm Eno2 Gpi Eno3 Vcan Fbp1 FLAVIN BIOSYNTHESIS IV (MAMMALIAN)%HUMANCYC%11070 flavin biosynthesis IV (mammalian) FATTY ACID &BETA;-OXIDATION III (UNSATURATED, ODD NUMBER)%HUMANCYC%PWY-5137 fatty acid β-oxidation III (unsaturated, odd number) Eci3 Ehhadh Eci1 S< I>-METHYL-5-THIO-&ALPHA;-D-RIBOSE 1-PHOSPHATE DEGRADATION%HUMANCYC%PWY-6755 S< i>-methyl-5-thio-α-D-ribose 1-phosphate degradation Mri1 Enoph1 Adi1 Apip GLYCINE DEGRADATION (CREATINE BIOSYNTHESIS)%HUMANCYC%GLYCGREAT-PWY glycine degradation (creatine biosynthesis) Gamt Gatm GLUTAMATE DEPENDENT ACID RESISTANCE%HUMANCYC%PWY0-1305 glutamate dependent acid resistance Gad1 Gad2 TRIACYLGLYCEROL BIOSYNTHESIS%HUMANCYC%TRIGLSYN-PWY triacylglycerol biosynthesis Abhd5 Lppr3 Agpat2 Lppr4 Gpat2 Dgat1 Agpat9 Lppr2 Lclat1 Ppap2c Ppapdc1a Agpat5 Ppap2a Dgat2 Agpat6 Ppap2b Agpat3 Agpat4 Agpat1 Gpam Lpcat4 Lpcat3 Mogat1 TREHALOSE DEGRADATION II (TREHALASE)%HUMANCYC%PWY0-1182 trehalose degradation II (trehalase) Galm &ALPHA;-TOCOPHEROL DEGRADATION%HUMANCYC%PWY-6377 α-tocopherol degradation Cyp4f4 SPERMINE AND SPERMIDINE DEGRADATION I%HUMANCYC%PWY-6117 spermine and spermidine degradation I Sat2 Paox Sat1 Smox RGD1564480 Aoc3 NAD SALVAGE PATHWAY III%HUMANCYC%PWY3O-4106 NAD salvage pathway III Nmrk1 Nmnat1 Nmnat2 PYRUVATE FERMENTATION TO LACTATE%HUMANCYC%PWY-5481 pyruvate fermentation to lactate Ldhc Ldhb NAD BIOSYNTHESIS FROM 2-AMINO-3-CARBOXYMUCONATE SEMIALDEHYDE%HUMANCYC%PWY-5653 NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde Qprt Nadsyn1 Nmnat1 Nmnat2 FATTY ACID BIOSYNTHESIS INITIATION II%HUMANCYC%PWY-5966 fatty acid biosynthesis initiation II Oxsm PUTRESCINE DEGRADATION III%HUMANCYC%PWY-0 putrescine degradation III Sat2 Aldh2 Sat1 Maob Aldh3a1 Maoa Aldh1b1 Aldh3a2 Aldh3b1 DIPHTHAMIDE BIOSYNTHESIS%HUMANCYC%PWY-6482 diphthamide biosynthesis Dph5 CHOLESTEROL BIOSYNTHESIS III (VIA DESMOSTEROL)%HUMANCYC%PWY66-4 cholesterol biosynthesis III (via desmosterol) Fdft1 Ebp Dhcr24 Sqle Nsdhl Hsd17b7 Tm7sf2 Cyp51 Dhcr7 Sc5d TAURINE BIOSYNTHESIS%HUMANCYC%PWY-5331 taurine biosynthesis Cdo1 Csad 4-AMINOBUTYRATE DEGRADATION I%HUMANCYC%PWY-6535 4-aminobutyrate degradation I Aldh5a1 Abat TRNA SPLICING%HUMANCYC%PWY-6689 tRNA splicing Tsen54 Trpt1 Tsen15 TETRAHYDROBIOPTERIN BIOSYNTHESIS II%HUMANCYC%PWY-5664 tetrahydrobiopterin biosynthesis II Spr Pts Gch1 NAD SALVAGE PATHWAY II%HUMANCYC%NAD-BIOSYNTHESIS-II NAD salvage pathway II Pxylp1 Nt5e Nt5c3b Enpp1 Nudt12 Enpp3 Acp6 Nmrk1 Nmnat1 Nmnat2 PUTRESCINE BIOSYNTHESIS III%HUMANCYC%PWY-46 putrescine biosynthesis III Odc1 ADENOSINE NUCLEOTIDES DEGRADATION II%HUMANCYC%SALVADEHYPOX-PWY adenosine nucleotides degradation II Nt5e Xdh Ada Pnp Nt5c1a Nt5c3a 4-HYDROXYBENZOATE BIOSYNTHESIS%HUMANCYC%PWY-5754-1 4-hydroxybenzoate biosynthesis Tat LYSINE DEGRADATION II%HUMANCYC%LYSINE-DEG1-PWY lysine degradation II Aldh7a1 LOC100910414 Sccpdh ZYMOSTEROL BIOSYNTHESIS%HUMANCYC%PWY-6074 zymosterol biosynthesis Nsdhl Hsd17b7 Tm7sf2 Cyp51 TRYPTOPHAN DEGRADATION III (EUKARYOTIC)%HUMANCYC%TRYPTOPHAN-DEGRADATION-1 tryptophan degradation III (eukaryotic) Hadhb Acat2 Gcdh Kynu Haao Kmo Tdo2 RGD1562948 Acmsd Acat1 ADENINE AND ADENOSINE SALVAGE I%HUMANCYC%P121-PWY adenine and adenosine salvage I Aprt COENZYME A BIOSYNTHESIS%HUMANCYC%COA-PWY coenzyme A biosynthesis Coasy Ppcdc INOSITOL PYROPHOSPHATES BIOSYNTHESIS%HUMANCYC%PWY-6369 inositol pyrophosphates biosynthesis Ip6k1 Ppip5k1 Ip6k2 Ippk Ipmk D-MYO< I>-INOSITOL (1,3,4)-TRISPHOSPHATE BIOSYNTHESIS%HUMANCYC%PWY-6364 D-myo< i>-inositol (1,3,4)-trisphosphate biosynthesis Inpp5k Inpp5a Synj1 Itpka Itpkc Inpp5d Itpkb Pten Ocrl Synj2 Ipmk HISTIDINE DEGRADATION III%HUMANCYC%PWY-5030 histidine degradation III Hal Uroc1 Mthfd2l Mthfd2 Mthfd1 Ftcd Amdhd1 SUPERPATHWAY OF GERANYLGERANYLDIPHOSPHATE BIOSYNTHESIS I (VIA MEVALONATE)%HUMANCYC%PWY-5910 superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate) LOC100360417 Pmvk RGD1562948 Hadhb Acat2 Hmgcs1 Ggps1 Fdps Mvd Hmgcr Hmgcs2 RGD1564347 Idi1 Acat1 L-CYSTEINE DEGRADATION II%HUMANCYC%LCYSDEG-PWY L-cysteine degradation II Cth PHOSPHATIDYLETHANOLAMINE BIOSYNTHESIS III%HUMANCYC%PWY-6273 phosphatidylethanolamine biosynthesis III Ptdss2 THIOSULFATE DISPROPORTIONATION III (RHODANESE)%HUMANCYC%PWY-5350 thiosulfate disproportionation III (rhodanese) Tst UDP-N< I>-ACETYL-D-GALACTOSAMINE BIOSYNTHESIS I%HUMANCYC%PWY-5512 UDP-N< i>-acetyl-D-galactosamine biosynthesis I Gale L-CYSTEINE DEGRADATION III%HUMANCYC%PWY-5329 L-cysteine degradation III Mpst GLUTATHIONE-MEDIATED DETOXIFICATION I%HUMANCYC%PWY-4061 glutathione-mediated detoxification I Gstk1 Gsta5 Gsto2 Gsta1 Ggt7 Gstm4 Gstp1 Mgst3 Gstt1 LOC501110 Mgst1 Gstm7 Anpep Gstm5 Ggt6 Ggh Gstm1 PHOSPHOLIPASES%HUMANCYC%LIPASYN-PWY phospholipases Pnpla8 Pla2g16 LOC100911171 Plce1 Pla2g10 Plcg1 Pla2g2a Pla2g2f Pla2g12a Plcb1 Pla2g2d Pla2g2e Plcz1 Plcd3 Plcb2 Pla2g4a Pla2g6 Plch2 Plcd4 Plcd1 Pla2g4cl1 Pla2g3 Pla2g4c Plch1 Pla2g4d Pla2g5 Pla2g4e Plcb3 Pld1 Pld2 Pld3 Plcb4 LOC686302 Pld4 Pld6 Pla2g1b SUPERPATHWAY OF CHOLESTEROL BIOSYNTHESIS%HUMANCYC%PWY66-5 superpathway of cholesterol biosynthesis LOC100360417 Pmvk RGD1562948 Sc5d Fdft1 Ebp Hadhb Dhcr24 Sqle Nsdhl Acat2 Hsd17b7 Tm7sf2 Cyp51 Hmgcs1 Ggps1 Dhcr7 Fdps Mvd Hmgcs2 Hmgcr RGD1564347 Idi1 Acat1 CHONDROITIN SULFATE DEGRADATION (METAZOA)%HUMANCYC%PWY-6573 chondroitin sulfate degradation (metazoa) Hyal5 Arsb Hyal4 Galns Hexa Hyal1 DOLICHOL AND DOLICHYL PHOSPHATE BIOSYNTHESIS%HUMANCYC%PWY-6129 dolichol and dolichyl phosphate biosynthesis Dolk Srd5a3 Dhdds ACETYL-COA BIOSYNTHESIS III (FROM CITRATE)%HUMANCYC%PWY-5172 acetyl-CoA biosynthesis III (from citrate) Acly TRYPTOPHAN DEGRADATION TO 2-AMINO-3-CARBOXYMUCONATE SEMIALDEHYDE%HUMANCYC%PWY-5651 tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde Kynu Haao Kmo Tdo2 ACYL-COA HYDROLYSIS%HUMANCYC%PWY-5148 acyl-CoA hydrolysis Acot9 Acot7 Acot8 DOPAMINE DEGRADATION%HUMANCYC%PWY6666-2 dopamine degradation Sult1a1 Maob Maoa Aldh3a2 Comt STEARATE BIOSYNTHESIS I (ANIMALS)%HUMANCYC%PWY-5972 stearate biosynthesis I (animals) Acot4 Acsl4 Acsl5 Acsbg1 Acot7 Slc27a2 Acsl1 Acsbg2 Elovl6 Acot2 Acot3 Acsl3 SUPERPATHWAY OF INOSITOL PHOSPHATE COMPOUNDS%HUMANCYC%PWY-6371 superpathway of inositol phosphate compounds Plce1 Plcg1 Pik3r3 Pik3r4 Pik3r1 Mtmr3 Pik3c2g Plcb1 Pi4kb Pik3r5 Pik3r6 Plcz1 Tmem55b Pip4k2b Plcd3 Plcb2 Pip4k2c Pikfyve Pik3r2 Pi4k2b Plch2 Pik3c3 Plcd4 Tmem55a Plcd1 Plch1 Plcb3 Sacm1l Pik3c2b Pik3c2a Plcb4 Inpp5k Inpp5a Synj1 Itpka Ip6k1 Itpkc Inpp5d Ppip5k1 Ip6k2 Itpkb Ippk Ocrl Ipmk Pik3cd Pik3cb Cdipt Itpk1 Mtmr14 Pik3cg Fig4 Pten Synj2 Pip5k1c Pi4k2a Pip5k1b METHYLTHIOPROPIONATE BIOSYNTHESIS%HUMANCYC%PWY-5389 methylthiopropionate biosynthesis Adi1 1D-MYO< I>-INOSITOL HEXAKISPHOSPHATE BIOSYNTHESIS V (FROM INS(1,3,4)P3)%HUMANCYC%PWY-6554 1D-myo< i>-inositol hexakisphosphate biosynthesis V (from Ins(1,3,4)P3) Itpk1 Ippk Ipmk S< I>-METHYL-5'-THIOADENOSINE DEGRADATION II%HUMANCYC%PWY-6756 S< i>-methyl-5'-thioadenosine degradation II GLYCEROL-3-PHOSPHATE SHUTTLE%HUMANCYC%PWY-6118 glycerol-3-phosphate shuttle Gpd1 Gpd2 PHOSPHATIDYLCHOLINE BIOSYNTHESIS I%HUMANCYC%PWY3O-450 phosphatidylcholine biosynthesis I Pcyt1b Pcyt1a Cept1 Chka Chkb TRIACYLGLYCEROL DEGRADATION%HUMANCYC%LIPAS-PWY triacylglycerol degradation Mgll Abhd6 Pnlip Lipg LOC100911615 Pnliprp2 Abhd12 Pnpla2 Pnpla3 Cel RGD1562200 Lipe Lipf GLUTARYL-COA DEGRADATION%HUMANCYC%PWY-5177 glutaryl-CoA degradation Hadhb Acat2 Gcdh RGD1562948 Acat1 TRANS, TRANS< I>-FARNESYL DIPHOSPHATE BIOSYNTHESIS%HUMANCYC%PWY-5123 trans, trans< i>-farnesyl diphosphate biosynthesis LOC100360417 Ggps1 Fdps RGD1564347 Idi1 GLUTAMATE REMOVAL FROM FOLATES%HUMANCYC%PWY-2161B glutamate removal from folates Ggh ACYL CARRIER PROTEIN METABOLISM%HUMANCYC%PWY-6012 acyl carrier protein metabolism Aasdhppt GERANYLGERANYLDIPHOSPHATE BIOSYNTHESIS%HUMANCYC%PWY-5120 geranylgeranyldiphosphate biosynthesis Ggps1 1D-MYO< I>-INOSITOL HEXAKISPHOSPHATE BIOSYNTHESIS II (MAMMALIAN)%HUMANCYC%PWY-6362 1D-myo< i>-inositol hexakisphosphate biosynthesis II (mammalian) Inpp5k Inpp5a Synj1 Itpka Itpkc Inpp5d Itpk1 Itpkb Ippk Ocrl Synj2 Ipmk CHOLESTEROL BIOSYNTHESIS I%HUMANCYC%PWY66-341 cholesterol biosynthesis I Fdft1 Ebp Dhcr24 Sqle Nsdhl Hsd17b7 Tm7sf2 Cyp51 Dhcr7 Sc5d ALANINE BIOSYNTHESIS II%HUMANCYC%ALANINE-SYN2-PWY alanine biosynthesis II Gpt FATTY ACID &ALPHA;-OXIDATION II%HUMANCYC%PWY66-387 fatty acid α-oxidation II Acsl4 Acsl5 Phyh Acsbg1 Acsl6 Slc27a2 Acsl1 Hacl1 Acsbg2 Acsl3 GLUTAMINE BIOSYNTHESIS I%HUMANCYC%GLNSYN-PWY glutamine biosynthesis I PHENYLETHYLAMINE DEGRADATION I%HUMANCYC%2PHENDEG-PWY phenylethylamine degradation I Aldh2 Aoc3 Aldh3a2 MEVALONATE PATHWAY I%HUMANCYC%PWY-922 mevalonate pathway I Hadhb Acat2 Pmvk Hmgcs1 RGD1562948 Mvd Hmgcs2 Hmgcr RGD1564347 Idi1 Acat1 SPHINGOMYELIN METABOLISM%HUMANCYC%PWY3DJ-11281 sphingomyelin metabolism Smpd2 Smpd4 Enpp7 Samd8 Sgms2 Sgms1 Smpd1 Smpd3 CYSTEINE BIOSYNTHESIS HOMOCYSTEINE DEGRADATION%HUMANCYC%HOMOCYSDEGR-PWY cysteine biosynthesis homocysteine degradation Cbs Cth GDP-L-FUCOSE BIOSYNTHESIS I (FROM GDP-D-MANNOSE)%HUMANCYC%PWY-66 GDP-L-fucose biosynthesis I (from GDP-D-mannose) Tsta3 Gmds SUPERPATHWAY OF SERINE AND GLYCINE BIOSYNTHESIS I%HUMANCYC%SER-GLYSYN-PWY superpathway of serine and glycine biosynthesis I Phgdh Shmt1 Psph Shmt2 Psat1 5-AMINOIMIDAZOLE RIBONUCLEOTIDE BIOSYNTHESIS I%HUMANCYC%PWY-6121 5-aminoimidazole ribonucleotide biosynthesis I LOC100912917 Gart Pfas Ppat GDP-L-FUCOSE BIOSYNTHESIS II (FROM L-FUCOSE)%HUMANCYC%PWY-6 GDP-L-fucose biosynthesis II (from L-fucose) Fpgt Fuk N< I>-ACETYLGLUCOSAMINE DEGRADATION I%HUMANCYC%GLUAMCAT-PWY N< i>-acetylglucosamine degradation I Amdhd2 Gnpda2 D-MYO< I>-INOSITOL (1,4,5,6)-TETRAKISPHOSPHATE BIOSYNTHESIS%HUMANCYC%PWY-6366 D-myo< i>-inositol (1,4,5,6)-tetrakisphosphate biosynthesis Itpk1 Ipmk FORMALDEHYDE OXIDATION II (GLUTATHIONE-DEPENDENT)%ECOCYC%PWY-1801 formaldehyde oxidation II (glutathione-dependent) Esd UDP-N< I>-ACETYL-D-GALACTOSAMINE BIOSYNTHESIS II%HUMANCYC%PWY-5514 UDP-N< i>-acetyl-D-galactosamine biosynthesis II Gale Gpi Gnpda2 Uap1 Pgm3 Gnpnat1 2-AMINO-3-CARBOXYMUCONATE SEMIALDEHYDE DEGRADATION TO GLUTARYL-COA%HUMANCYC%PWY-5652 2-amino-3-carboxymuconate semialdehyde degradation to glutaryl-CoA Acmsd L-SERINE DEGRADATION%HUMANCYC%SERDEG-PWY L-serine degradation Sds Sdsl ACETATE CONVERSION TO ACETYL-COA%HUMANCYC%PWY0-1313 acetate conversion to acetyl-CoA Acss2 Acss3 Acss1 THYROID HORMONE BIOSYNTHESIS%HUMANCYC%PWY-6241 thyroid hormone biosynthesis Tpo Ctsd ANDROGEN BIOSYNTHESIS%HUMANCYC%PWY66-378 androgen biosynthesis Hsd3b1 Hsd3b Hsd3b2 LOC100911154 Cyp17a1 Akr1c3 Srd5a2 Srd5a1 Hsd17b3 FOLATE POLYGLUTAMYLATION%HUMANCYC%PWY-2161 folate polyglutamylation Mthfd1l Mthfd1 Shmt1 Shmt2 CHOLINE BIOSYNTHESIS III%HUMANCYC%PWY-3561 choline biosynthesis III Pld1 Pcyt1b Pld2 Pcyt1a Pld3 Cept1 Pld4 Pld6 INOSINE-5'-PHOSPHATE BIOSYNTHESIS II%HUMANCYC%PWY-6124 inosine-5'-phosphate biosynthesis II Adsl Paics Atic DERMATAN SULFATE BIOSYNTHESIS (LATE STAGES)%HUMANCYC%PWY-6568 dermatan sulfate biosynthesis (late stages) Chst14 Dse Chst15 Ust URATE BIOSYNTHESIS INOSINE 5'-PHOSPHATE DEGRADATION%HUMANCYC%PWY-5695 urate biosynthesis inosine 5'-phosphate degradation Impdh2 Nt5e Nt5c3b Xdh Pnp Impdh1 URIDINE-5'-PHOSPHATE BIOSYNTHESIS%HUMANCYC%PWY-5686 uridine-5'-phosphate biosynthesis Umps Cad METHYLGLYOXAL DEGRADATION III%HUMANCYC%PWY-5453 methylglyoxal degradation III Akr1b1 Cyp2e1 Akr1b8 PURINE NUCLEOTIDES DEGRADATION II (AEROBIC)%HUMANCYC%PWY-6353 purine nucleotides degradation II (aerobic) Impdh2 Nt5e Nt5c3b Xdh Ada Pnp Nt5c1a Nt5c3a Gda Impdh1 FATTY ACID ACTIVATION%HUMANCYC%PWY-5143 fatty acid activation Acsl4 Acsl5 Acsbg1 Acsl6 Slc27a2 Acsl1 Acsbg2 Acsl3 CERAMIDE DEGRADATION%HUMANCYC%PWY-6483 ceramide degradation Asah2 SALVAGE PATHWAYS OF PYRIMIDINE DEOXYRIBONUCLEOTIDES%HUMANCYC%PWY0-181 salvage pathways of pyrimidine deoxyribonucleotides Tymp Tk2 Cda LOC100909857 aicda 3-PHOSPHOINOSITIDE BIOSYNTHESIS%HUMANCYC%PWY-6352 3-phosphoinositide biosynthesis Pik3r3 Pik3r4 Pik3r1 Pik3cd Pik3c2g Pik3cb Pi4kb Pik3r5 Pik3r6 Cdipt Pip4k2b Pik3cg Pikfyve Fig4 Pik3r2 Pip5k1c Pi4k2b Pik3c3 Pi4k2a Pip5k1b Sacm1l Pik3c2b Pik3c2a SPERMIDINE BIOSYNTHESIS I%HUMANCYC%BSUBPOLYAMSYN-PWY spermidine biosynthesis I LOC100364487 Amd1 LOC100912604 Srm ADENINE AND ADENOSINE SALVAGE III%HUMANCYC%PWY-6609 adenine and adenosine salvage III Ada Pnp PENTOSE PHOSPHATE PATHWAY%HUMANCYC%PENTOSE-P-PWY pentose phosphate pathway Tktl2 Rpia Pgls Tkt Rpe H6pd Tktl1 Taldo1 NAD BIOSYNTHESIS II (FROM TRYPTOPHAN)%HUMANCYC%NADSYN-PWY NAD biosynthesis II (from tryptophan) Qprt Kynu Nadsyn1 Haao Kmo Tdo2 Nmnat1 Nmnat2 PROTEIN CITRULLINATION%HUMANCYC%PWY-4921 protein citrullination Padi4 Padi1 Padi2 Padi3 Padi6 D-MYO< I>-INOSITOL (1,4,5)-TRISPHOSPHATE BIOSYNTHESIS%HUMANCYC%PWY-6351 D-myo< i>-inositol (1,4,5)-trisphosphate biosynthesis Plce1 Pi4kb Plcb1 Plcg1 Cdipt Plcz1 Pip4k2b Plcd3 Pip4k2c Plcb2 Plch2 Pip5k1c Pi4k2b Pi4k2a Plcd4 Plcd1 Pip5k1b Plch1 Plcb3 Plcb4 PROLINE BIOSYNTHESIS II (FROM ARGININE)%HUMANCYC%PWY-4981 proline biosynthesis II (from arginine) Otc Pycr2 Pycrl Pycr1 Oat GLUTAMATE DEGRADATION II%HUMANCYC%GLUTDEG-PWY glutamate degradation II Got1 Got1l1 Got2 PENTOSE PHOSPHATE PATHWAY (OXIDATIVE BRANCH)%HUMANCYC%OXIDATIVEPENT-PWY pentose phosphate pathway (oxidative branch) Pgls H6pd KETOLYSIS%HUMANCYC%REACT_59.NULL ketolysis Hadhb Bdh1 Oxct1 Bdh2 Acat1 SPHINGOSINE AND SPHINGOSINE-1-PHOSPHATE METABOLISM%HUMANCYC%PWY3DJ-11470 sphingosine and sphingosine-1-phosphate metabolism Acer1 Ptgr1 Acer2 Asah1 Sphk2 Asah2 Sgpp2 Sphk1 HEME BIOSYNTHESIS II%HUMANCYC%PWY-5920 heme biosynthesis II Cpox Alad Uros Urod Hmbs Fech Alas2 Ppox HEME BIOSYNTHESIS FROM UROPORPHYRINOGEN-III I%HUMANCYC%HEME-BIOSYNTHESIS-II heme biosynthesis from uroporphyrinogen-III I Cpox Urod Fech Ppox TYROSINE BIOSYNTHESIS IV%HUMANCYC%PWY-6134 tyrosine biosynthesis IV Pah FATTY ACID &BETA;-OXIDATION I%HUMANCYC%FAO-PWY fatty acid β-oxidation I Acsl4 Hadhb Acsl5 Acsbg1 Slc27a2 Acsl6 Eci3 Acsl1 Acsbg2 Hadh Hsd17b10 Ehhadh Echs1 Acaa2 Eci1 Hadha Acsl3 CMP-N< I>-ACETYLNEURAMINATE BIOSYNTHESIS I (EUKARYOTES)%HUMANCYC%PWY-6138 CMP-N< i>-acetylneuraminate biosynthesis I (eukaryotes) Cmas Nanp Nans Gne ARGININE BIOSYNTHESIS IV%HUMANCYC%ARGININE-SYN4-PWY arginine biosynthesis IV Asl Ass1 Otc Oat NORADRENALINE AND ADRENALINE DEGRADATION%HUMANCYC%PWY-6342 noradrenaline and adrenaline degradation Aldh2 Adh6 Maob Maoa Aldh3a2 Lrtomt Comt Adh4 CARDIOLIPIN BIOSYNTHESIS II%HUMANCYC%PWY-5269 cardiolipin biosynthesis II Pgs1 Crls1 SERINE BIOSYNTHESIS%HUMANCYC%SERSYN-PWY serine biosynthesis Phgdh Psph Psat1 SEROTONIN AND MELATONIN BIOSYNTHESIS%HUMANCYC%PWY-6030 serotonin and melatonin biosynthesis Tph1 Tph2 Aanat Asmt Ddc ETHANOL DEGRADATION II%HUMANCYC%PWY66-21 ethanol degradation II Aldh2 Acss2 Acss3 Acss1 Aldh3a2 D-GLUCURONATE DEGRADATION I%HUMANCYC%PWY-5525 D-glucuronate degradation I Cryl1 L-CYSTEINE DEGRADATION I%HUMANCYC%CYSTEINE-DEG-PWY L-cysteine degradation I Cdo1 Got1 METHYLGLYOXAL DEGRADATION I%HUMANCYC%PWY-5386 methylglyoxal degradation I Glo1 Ldhd Hagh N< I>-ACETYLGLUCOSAMINE DEGRADATION II%HUMANCYC%PWY-6517 N< i>-acetylglucosamine degradation II Amdhd2 Gnpda2 Nagk METHYLMALONYL PATHWAY%HUMANCYC%PROPIONMET-PWY methylmalonyl pathway Mcee Pccb GLUTATHIONE REDOX REACTIONS I%HUMANCYC%PWY-4081 glutathione redox reactions I Gpx5 Gpx4 Gpx1 Gpx6 Gpx2 Gpx7 Gpx8 Gsr Gpx3 (S)-RETICULINE BIOSYNTHESIS II%HUMANCYC%PWY-6133 (S)-reticuline biosynthesis II Tyr CITRULLINE DEGRADATION%HUMANCYC%CITRULLINE-DEG-PWY citrulline degradation Otc LACTOSE DEGRADATION III%HUMANCYC%BGALACT-PWY lactose degradation III Glb1 L-DOPACHROME BIOSYNTHESIS%HUMANCYC%PWY-6481 L-dopachrome biosynthesis Tyr GLUTAMATE DEGRADATION X%HUMANCYC%PWY-5766 glutamate degradation X PRPP BIOSYNTHESIS I%HUMANCYC%PWY0-662 PRPP biosynthesis I Prps2 Prps1l1 SORBITOL DEGRADATION I%HUMANCYC%PWY-4101 sorbitol degradation I Sord 1,25-DIHYDROXYVITAMIN D3< SUB> BIOSYNTHESIS%HUMANCYC%PWY-6076 1,25-dihydroxyvitamin D3< sub> biosynthesis Cyp2r1 Por CERAMIDE BIOSYNTHESIS%HUMANCYC%PWY3DJ-12 ceramide biosynthesis Sptlc2 Kdsr Degs2 Sptlc1 Sptlc3 L-GLUTAMINE BIOSYNTHESIS II (TRNA-DEPENDENT)%HUMANCYC%PWY-5921 L-glutamine biosynthesis II (tRNA-dependent) Qrsl1 ANANDAMIDE DEGRADATION%HUMANCYC%PWY6666-1 anandamide degradation Faah HISTAMINE BIOSYNTHESIS%HUMANCYC%PWY-6173 histamine biosynthesis Hdc PYRIMIDINE RIBONUCLEOTIDES INTERCONVERSION%HUMANCYC%PWY-5687 pyrimidine ribonucleotides interconversion Nme7 Nme6 Ctps2 Cmpk1 Nme3 Ctps1 Nme1 Cmpk2 Cant1 Decr2 UDP-N< I>-ACETYL-D-GLUCOSAMINE BIOSYNTHESIS II%HUMANCYC%UDPNACETYLGALSYN-PWY UDP-N< i>-acetyl-D-glucosamine biosynthesis II Gfpt2 Gfpt1 Uap1 Pgm3 Gnpnat1 TRYPTOPHAN DEGRADATION X (MAMMALIAN, VIA TRYPTAMINE)%HUMANCYC%PWY-6307 tryptophan degradation X (mammalian, via tryptamine) Maob Maoa Ddc Aldh3a2 Akr1a1 DERMATAN SULFATE DEGRADATION (METAZOA)%HUMANCYC%PWY-6576 dermatan sulfate degradation (metazoa) Hyal5 Hexa Hyal1 ALL-TRANS< I>-DECAPRENYL DIPHOSPHATE BIOSYNTHESIS%HUMANCYC%PWY-5806 all-trans< i>-decaprenyl diphosphate biosynthesis Pdss2 THYMINE DEGRADATION%HUMANCYC%PWY-6430 thymine degradation LOC103692570 Upb1 Dpys Crmp1 LOC100910964 Dpysl3 Dpysl2 Dpysl5 Dpysl4 ALANINE BIOSYNTHESIS III%HUMANCYC%PWY0-1021 alanine biosynthesis III Nfs1 LOC100911034 LANOSTEROL BIOSYNTHESIS%HUMANCYC%PWY-6132 lanosterol biosynthesis URACIL DEGRADATION II (REDUCTIVE)%ARACYC%PWY-3982 uracil degradation II (reductive) LOC103692570 Upb1 Dpys Crmp1 LOC100910964 Dpysl3 Dpysl2 Dpysl5 Dpysl4 PYRIMIDINE RIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%HUMANCYC%PWY0-162 pyrimidine ribonucleotides de novo< i> biosynthesis Nme7 Nme6 Ctps2 Cmpk1 Nme3 Ctps1 Nme1 Cmpk2 Cant1 Decr2 Umps Cad GLUCOSE AND GLUCOSE-1-PHOSPHATE DEGRADATION%HUMANCYC%GLUCOSE1PMETAB-PWY glucose and glucose-1-phosphate degradation Pgm5 Pgm1 Pgm2 OLEATE BIOSYNTHESIS II (ANIMALS)%HUMANCYC%PWY-5996 oleate biosynthesis II (animals) Acot4 Fads6 Fads1 Scd1 Acot2 Acot3 PHOSPHATIDYLETHANOLAMINE BIOSYNTHESIS II%HUMANCYC%PWY4FS-6 phosphatidylethanolamine biosynthesis II Ept1 Etnk1 Pcyt2 Cept1 Chkb PHENYLALANINE DEGRADATION I (AEROBIC)%HUMANCYC%PHENYLALANINE-DEG1-PWY phenylalanine degradation I (aerobic) Pah Pcbd1 Qdpr CALCIUM TRANSPORT I%HUMANCYC%PWY-6166 calcium transport I Atp2a3 Atp2c1 Atp2a2 PURINE RIBONUCLEOSIDES DEGRADATION TO RIBOSE-1-PHOSPHATE%HUMANCYC%PWY0-1296 purine ribonucleosides degradation to ribose-1-phosphate Ada Pnp 4-HYDROXYPROLINE DEGRADATION I%HUMANCYC%HYDROXYPRODEG-PWY 4-hydroxyproline degradation I ASPARTATE DEGRADATION II%HUMANCYC%MALATE-ASPARTATE-SHUTTLE-PWY aspartate degradation II Mdh1 Mdh2 Got1 Got1l1 Got2 GLUTAMATE BIOSYNTHESIS II%HUMANCYC%GLUTAMATE-SYN2-PWY glutamate biosynthesis II CHOLESTEROL BIOSYNTHESIS II (VIA 24,25-DIHYDROLANOSTEROL)%HUMANCYC%PWY66-3 cholesterol biosynthesis II (via 24,25-dihydrolanosterol) Fdft1 Ebp Dhcr24 Sqle Nsdhl Hsd17b7 Tm7sf2 Cyp51 Dhcr7 Sc5d GLUTAMATE DEGRADATION III (VIA 4-AMINOBUTYRATE)%HUMANCYC%GLUDEG-I-PWY glutamate degradation III (via 4-aminobutyrate) Aldh5a1 Gad1 Gad2 Abat GLYCOGEN DEGRADATION III%HUMANCYC%PWY-5767 glycogen degradation III Pgm5 Pgm1 Pgm2 Gaa Pygm Pygl Pygb Agl ETHANOL DEGRADATION IV%HUMANCYC%PWY66-162 ethanol degradation IV Aldh2 Acss2 Acss3 Cat Tyrp1 Acss1 Aldh3a2 TETRAHYDROFOLATE SALVAGE FROM 5,10-METHENYLTETRAHYDROFOLATE%HUMANCYC%PWY-6613 tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate Gart Mthfd2l Mthfd2 Mthfd1 EPOXYSQUALENE BIOSYNTHESIS%HUMANCYC%PWY-5670 epoxysqualene biosynthesis Fdft1 Sqle NAD PHOSPHORYLATION AND DEPHOSPHORYLATION%HUMANCYC%NADPHOS-DEPHOS-PWY NAD phosphorylation and dephosphorylation Pxylp1 Nnt Acp6 CREATINE-PHOSPHATE BIOSYNTHESIS%HUMANCYC%PWY-6158 creatine-phosphate biosynthesis Ckmt1b Ckm Ckb ADENINE AND ADENOSINE SALVAGE VI%HUMANCYC%PWY-6619 adenine and adenosine salvage VI Adk D-MYO< I>-INOSITOL-5-PHOSPHATE METABOLISM%HUMANCYC%PWY-6367 D-myo< i>-inositol-5-phosphate metabolism Mtmr3 Plce1 Plcb1 Plcg1 Tmem55b Plcz1 Plcd3 Pip4k2c Mtmr14 Plcb2 Plch2 Plcd4 Tmem55a Plcd1 Plch1 Plcb3 Plcb4 PENTOSE PHOSPHATE PATHWAY (NON-OXIDATIVE BRANCH)%HUMANCYC%NONOXIPENT-PWY pentose phosphate pathway (non-oxidative branch) Tktl2 Rpia Tkt Rpe Tktl1 Taldo1 SULFITE OXIDATION IV%HUMANCYC%PWY-5326 sulfite oxidation IV Suox NAD BIOSYNTHESIS III%HUMANCYC%NAD-BIOSYNTHESIS-III NAD biosynthesis III Nampt Nmnat1 Nmnat2 METHYLGLYOXAL DEGRADATION VI%HUMANCYC%MGLDLCTANA-PWY methylglyoxal degradation VI Ldhd &GAMMA;-GLUTAMYL CYCLE%HUMANCYC%PWY-4041 γ-glutamyl cycle Ggt7 Anpep Dpp8 Oplah Ggct Ggt6 Gclc Gss Cndp2 Gclm LEUKOTRIENE BIOSYNTHESIS%HUMANCYC%15354 leukotriene biosynthesis Lta4h Ltc4s Alox5 Dpep2 Dpep1 NADH REPAIR%HUMANCYC%PWY-6938 NADH repair Apoa1bp SUCROSE DEGRADATION V (MAMMALIAN)%HUMANCYC%PWY66-373 sucrose degradation V (mammalian) Galm Aldob Si Aldoa Khk 2-OXOBUTANOATE DEGRADATION I%HUMANCYC%PWY-5130 2-oxobutanoate degradation I Bckdhb Bckdha Dld Mcee Pccb Dbt 3-PHOSPHOINOSITIDE DEGRADATION%HUMANCYC%PWY-6368 3-phosphoinositide degradation Mtmr3 Tmem55b Mtmr14 Pten Synj2 Tmem55a Inpp5k Ptpmt1 Synj1 Inpp4a Inpp4b Sacm1l Inpp5d Inpp5f Ocrl DTMP DE NOVO< I> BIOSYNTHESIS%HUMANCYC%PWY66-385 dTMP de novo< i> biosynthesis Dhfr Shmt1 Tyms Shmt2 ARGININE DEGRADATION I (ARGINASE PATHWAY)%HUMANCYC%ARGASEDEG-PWY arginine degradation I (arginase pathway) Arg1 Oat MITOCHONDRIAL L-CARNITINE SHUTTLE PATHWAY%HUMANCYC%PWY-6111 mitochondrial L-carnitine shuttle pathway Cpt2 Cpt1a Cpt1c &BETA;-ALANINE DEGRADATION I%HUMANCYC%BETA-ALA-DEGRADATION-I-PWY β-alanine degradation I Aldh6a1 Abat ALANINE DEGRADATION III%HUMANCYC%ALANINE-DEG3-PWY alanine degradation III Gpt GLYCOGEN DEGRADATION II%HUMANCYC%PWY-5941 glycogen degradation II Pgm5 Pgm1 Pgm2 Pygm Pygl Pygb Agl HISTAMINE DEGRADATION%HUMANCYC%PWY-6181 histamine degradation Hnmt Aoc1 THIAMIN SALVAGE III%HUMANCYC%PWY-6898 thiamin salvage III Tpk1 D-MYO< I>-INOSITOL (3,4,5,6)-TETRAKISPHOSPHATE BIOSYNTHESIS%HUMANCYC%PWY-6365 D-myo< i>-inositol (3,4,5,6)-tetrakisphosphate biosynthesis Itpk1 Ipmk FATTY ACID &ALPHA;-OXIDATION III%HUMANCYC%PWY66-388 fatty acid α-oxidation III Hacl1 Aldh3a2 GLYCOLYSIS I%HUMANCYC%GLYCOLYSIS glycolysis I Gapdhs Aldob Pgk2 LOC100911625 Aldoa Fbp2 Pgk1 Eno1 Pgam2 Bpgm Eno2 Gpi Pfkp Pkm Eno3 Pfkl Vcan Fbp1 Pklr OXIDIZED GTP AND DGTP DETOXIFICATION%HUMANCYC%PWY-6502 oxidized GTP and dGTP detoxification Nudt1 TRNA CHARGING%HUMANCYC%TRNA-CHARGING-PWY tRNA charging Farsa Farsb Rars Lars Fars2 Nars Yars2 Lars2 Dars2 Tars Eprs Nars2 Hars Qars Mars2 Kars Cars Yars Wars Iars Tarsl2 Rars2 Ears2 Dars Aars2 LOC100911305 Pars2 Aars Gars Wars2 Sars2 Sars ALPHA6BETA4INTEGRIN%IOB%ALPHA6BETA4INTEGRIN Alpha6Beta4Integrin Rpsa Src Itga6 Vim Cd151 Sfn Pik3r2 Pik3r1 Pik3r3 Mtor Smad2 Mylk3 Smad3 Eif4ebp1 Ephb2 Tp73 Prkca Lama1 Abl1 Ntn1 Col17a1 Egfr Casp3 Ar Lamb2 Lamb3 Mst1r Plec Fyn Prkcd Ywhaz LOC100911730 Erbb2 Ptk2 Bad Eif6 Pak1 Lamb1 Ywhae Shc1 Grb2 Pik3cg Pik3cb Ptpn11 Pik3cd Dsp Itgb4 Lamc2 Akt1 Ywhab Rhoa Clca1 Clca2 Ywhah Yes1 Rac1 Irs2 Rtkn LOC100909750 Irs1 Lamc1 TRAIL%IOB%TRAIL TRAIL Mapk9 Mapk8 Nfkb1 Aifm1 Prkdc Apaf1 Vdac1 Ngfrap1 Fadd Cycs Bax Mapk14 Traf2 H2afx Tnfsf10 Casp2 Atm Casp1 Nfkbia Akt1 Bid Ctsb Tradd Bak1 Casp8 Src Tnfrsf11b Jun Prkaa1 Casp3 Chek2 Bcl10 Creb1 Cbl Diablo Dap3 Cflar Mapk1 Csnk2a1 Parp1 Map3k7 Irf5 Ripk1 Xiap Rela LEPTIN%IOB%LEPTIN Leptin Cfl2 Map2k6 Nfkb1 Rps6ka2 Rps6 Slc2a4 Gsk3a LOC100911372 Atf2 Grb2 Mapk14 Stat1 Ptpn11 Stat5b Sp1 Raf1 Pde3a Akt1 Jak3 Elk1 Pdia3 Prkcz Lepr Gsk3b Pten Mapkapk2 Irs2 Th Lep Khdrbs1 Irs1 Map2k2 Rps6kb1 Map2k1 Pik3r2 Pik3r1 Leprot Egfr Hspb1 Stat3 Prkcd Mapk1 Ptk2 IFN-ALPHA%IOB%IFN-ALPHA IFN-alpha Prkcq Crk Map2k6 Map2k4 Rps6 Pla2g4a LOC100911372 Crkl Zap70 Stat5a Vav1 Mapk14 Arhgap30 Stat1 Ifnar1 Rps6ka5 Stat5b Nfkbia Akt1 Stat6 Irs2 Jak1 LOC100911248 Erbb3 Irs1 Rps6kb1 Mtor Eif4ebp1 Stat3 Foxo1 Stat2 Eif4b Cbl Prkcd NGF%IOB%NGF NGF Plcg1 Shc1 Prkci Dnaja3 Ntrk1 Frs2 Ptpn11 Sp1 Gab1 Creb1 Elk1 Rps6ka1 Mapk1 Bad Map2k2 Map2k1 EGFR1%IOB%EGFR1 EGFR1 Mt-co2 Tkt Tln1 Cyld Snca Pvrl1 Plekhn1 S100a10 Ap2a1 Git1 Anxa2 Anxa4 Dyrk3 Anxa1 Myo6 Ralbp1 Ctnnd1 Rplp0 Flnb Rasa1 Krt7 Pxn Krt8 Pkn2 Aldoa Map2k7 Src Map2k5 Vim Slc12a7 Tfrc Git2 Acp1 Caskin2 Pik3r2 Cfl1 Pik3r1 Htt Pik3r3 Clta Mtor Iqgap1 Smad2 Pkp3 Pkp4 Smad3 Csk Eif4ebp1 Epn3 Ephb2 Eef1a2 Tollip Prkca Gsn Crim1 Abl1 Eps15l1 Grb10 Col17a1 Grb14 Egfr Lsr Ptpn1 Ptk2b Cdv3 Gprc5a Cblc Plec Ptpn6 Fyn Cblb Prkcd Mta2 Ywhaz LOC100911597 Hras Erbb2 Araf Ptk2 Sfpq Bad Dusp1 Cltc Pak1 Mink1 Adam17 LOC100909609 Stx4 Atp1a1 Atf1 Bcl2 Cstb Abi1 Rpl30 Arf4 Ptpre Elf3 Etl4 Cav2 Ptpra Asap1 Mpzl1 LOC100911431 Mvp Atp5c1 Dock1 Camk2a Epn1 Slitrk6 Alb Frk Pik3c2b Cebpa LOC100912399 Stxbp1 Elmo2 Sos1 Tgif1 Mprip Socs1 Socs3 Ctbp1 Spry4 Arhgap32 Cttn Spry1 Ralb Cd59 Cysrt1 Gja1 Lpp Sh2d2a Usp6nl Tjp2 Trim29 Spry2 Zfp259 Esyt1 Itsn2 Sdcbp Arhgap35 Fos Mapk9 Mapk8 Nfkb1 Mapk14 Jun Prkaa1 Creb1 Cbl Mapk1 Ripk1 Rela Shc1 Grb2 Pik3cg Pik3cb Ptpn11 Pik3cd Dsp Itgb4 Akt1 Ywhab Rhoa Rac1 Irs2 LOC100909750 Rps6ka2 Gsk3a Sp1 Raf1 Elk1 Prkcz Gsk3b Pten Khdrbs1 Map2k2 Map2k1 Crk Crkl Stat5a Vav1 Stat1 Rps6ka5 Stat5b Jak1 LOC100911248 Erbb3 Rps6kb1 Stat3 Foxo1 Stat2 Actr3 Hnrnpdl Laptm4a Taf3 Pebp1 Prkaa2 Vasp Atxn2 Baiap2 Eno1 Dsg2 Sirpa Rgs16 Pdlim1 Actr2 Tagln2 Kirrel Ptprr Insr Hdac1 Snx5 Cdh1 Cdh2 Cdh3 Zdhhc5 Snx33 Ptprf Ptpn18 Slc38a2 Jup Ensa Ptpn12 Tnip1 Anks1a Sh3gl2 Prpf4b Ptpn23 LOC689959 Sh3gl3 Snrpd2 Actn1 Prkcb Prkci Ddx3x Pkm Rbm3 Grb7 LOC680559 Gab2 Hdac1l Gab1 Vav3 Actn4 App Hat1 Vav2 Prkx Tom1l2 Phlpp1 Baiap2l1 Itga3 Rbbp7 Appl2 Adrbk1 Rin1 Elk4 Clk2 Pdzd11 Prkd1 Hipk2 Jund Abl2 Aplp2 Pdgfrb Sh3kbp1 Casp9 Ldlr Arap1 Pitpna Adam9 Tns4 Tp53 Tns2 Tns1 Kit Phpt1 Arhgef5 Slc5a5 Afap1l2 Pragmin Arhgef7 Ubash3b Ppp1r12a Siah2 Ppp2r3a Tfg Siah1 Sh3bgrl Antxr1 Hipk3 LOC100911794 Il17rd Nos3 Epha4 Otud6b Pttg1ip Nedd9 Usp31 Ptk6 Epha1 Wbp2 Slc25a5 Hnrnpr Arhgef4 Frs2 Epha2 Pygb Sdc3 Stam2 Dab2 Efnb2 Map4k5 Magi1 Map3k14 Sdc4 Dyrk1b Scrib Dyrk1a Dynll1 Ppp1r14b Dnm1 Ephb1 Ephb3 Ksr1 Lck Flot2 Flot1 Nck1 Rbck1 Stam Myh9 Plcg1 Pias3 Dcbld2 Dapp1 Racgap1 Krt18 Krt17 Ralgds Ap2s1 Tnk2 Ctnnal1 Vcl Rps6ka3 Rps6ka1 Stk11 Bcar1 Dok1 Nck2 Myc Dok2 Pard3 Plce1 Stip1 Plscr1 Map3k2 Map3k1 Map3k3 Pfn1 Bcar3 Eif4g1 Limd1 Tom1 Map3k4 Hip1 Actb Eps8 Pld2 Pdpk1 Rfxank Pld1 Smu1 Arhgap5 Dlg3 Zfyve16 Cc2d1a Ptrf Axl Rps2 Itgb1 Peak1 Cdk2 Cdk5 Lyn Myl12b Sdpr Cdk1 NOTCH%IOB%NOTCH Notch Nfkb1 Hdac1 Gsk3b Pik3r2 Psen1 Pik3r1 Psen2 Fhl1 Lfng LOC100911293 Smad3 Hdac2 Hdac1l App Mapk1 Adam17 Rela Cir1 Lck Nov Tle1 Numbl Cntn1 Sin3a Psenen Dll3 Pofut1 Hes5 Hes6 Ascl1 Wdr12 Aph1b Ncstn Hes1 Jag1 Ncor2 Snw1 Ring1 Notch3 Notch4 Notch1 Notch2 Hivep3 Smad1 Rbx1 Lef1 Yy1 Mfng Maml1 Cul1 Stat3 Bloc1s1 Furin Mef2c Skp1 Skp2 Hey1 Dll4 Hey2 THROMBOPOIETIN%IOB%THROMBOPOIETIN Thrombopoietin Stat3 Foxo3 Atxn2l Gab1 Mpl Mapk1 Shc1 Stat5b Map2k1 M-CSF%IOB%M-CSF M-CSF Inpp5d Pak2 Thoc5 Ptpn2 Pstpip2 Mitf Csf1 Ets2 Fadd Ppp2ca Skap2 Raf1 Rasa1 Pxn Casp8 Src Vim Khdrbs1 Map2k2 Map2k1 Pik3r1 Eif4ebp1 Gab2 Ptk2b Cbl Ptpn6 Prkcd Mapk1 Ptk2 Ripk1 Dnm1 Rps6 LOC100911372 Plcg1 Stat5a Shc1 Grb2 Stat1 Ptpn11 Stat5b Akt1 Bcar1 Jak1 Sos1 Rps6kb1 Sla2 Tfe3 Csf1r Stat3 Lyn TGF_BETA_RECEPTOR%IOB%TGF_BETA_RECEPTOR TGF_beta_Receptor Vdr Pard6a Mapk8 Brca1 Tfdp2 Arrb2 Ube2d1 Irf2bp1 Junb Mapk14 Pml Ube2d3 Fzr1 Ccne1 Runx2 Ncoa1 Cited1 Xpo1 Hdac1 Anapc5 Fnta Camk2g Xpo4 Nup153 Tgfbr1 Csnk1g2 Tgfbr2 Tgfbr3 Axin2 Kpnb1 Dvl1 Btrc Nme1 Ppp2r2a Rbl2 Rbl1 Ccnd1 Uchl5 LOC100911622 Anapc2 Anapc4 Prkcb Wwtr1 Anapc1 Anapc7 Ddx5 Jun Camk2d LOC100909678 Snx1 Hdac1l Hnf4a Snx2 Pias2 Pias1 Snx4 Acvrl1 Map4k1 Mapk1 Dynlrb2 Dynlrb1 Rb1 Map3k7 Rock1 Ing2 Snx6 Zfyve9 Cdc25a Nfya Ctcf Cdkn1a Sdc2 Anapc10 Pdk1 Tgfb1 Tgfb2 Strap Fkbp1a Shc1 Grb2 Smad6 Tgfb3 Smad7 Vps39 Atf3 Eid2 Snip1 Foxh1 Prkar2a Snw1 Cdc27 Akt1 Ewsr1 Rhoa Ets1 Stk11ip Crebbp Foxg1 Med15 Dync1i1 Rbx1 Sptbn1 Lef1 Nfyc Cdc16 LOC100912481 Nfyb Cul1 Prkar1b Esr1 Zeb2 Gipc1 Smurf1 Daxx Zeb1 Foxo4 Cdk4 Dcp1a E2f5 Sparc Skil Hoxa7 Cdk6 Cd44 Foxo3 Mef2c Skp1 Trap1 Jund Atf2 Ppp2ca Tp53 Sp1 Raf1 Pxn Pik3r2 Pik3r1 Smad2 Smad3 Tp73 Ar Dab2 Prkcd Ptk2 Crk Map2k6 Camk2a Stk11 Bcar1 Myc Pard3 Sos1 Tgif1 Foxo1 Zfyve16 Cdk2 Cdk1 Fos TIE1 TEK%IOB%TIE1 TEK TIE1 TEK Nos3 Nck1 Shc1 Stat5a Mapk14 Grb7 Stat5b Raf1 Foxo1 Akt1 Tek Elk1 Pxn Mapk1 Bmx Tie1 Fes Dok2 Ptk2 Map2k2 Pak1 Map2k1 TNFSF3%IOB%TNFSF3 TNFSF3 Tnfrsf1a Nfkbia Nfkb1 Traf3 Nfkb2 Ltbr Lta Tnfrsf1b Traf2 Jun Rela FLK2 FLT3%IOB%FLK2 FLT3 FLK2 FLT3 Inpp5d Atf1 Atf2 Shc1 Stat5a Jun Ptpn11 Stat5b Stat3 Gab2 Foxo3 Flt3 Gab1 Creb1 Akt1 Cbl Cblb Mapk1 Cebpa Lyn Bad TNFSF8%IOB%TNFSF8 TNFSF8 Nfkb1 Mapk14 Traf2 Nfkbia Akt1 Traf3 Nfkb2 Map3k14 Mapk1 Tnfrsf8 Ikbkb Chuk Rela Nfkbib FAS%IOB%FAS Fas Mapk9 Mapk8 Aifm1 Prkdc Fadd Bax Mapk14 Traf2 Casp2 Casp1 Insr Bid Casp8 Diablo Cflar Mapk1 Csnk2a1 Parp1 Rock1 Ripk1 Xiap Rela Akt1 Cdc27 Rac1 Daxx Traf3 Bmx Pak2 Casp9 Anxa4 Raf1 Rasa1 Pkn2 Gsk3b Vim Hipk3 Map2k2 Map2k1 Gsn Egfr Casp3 Ptpn6 Plec Fyn Prkcd Fas Lck Gtf3c3 Max Ube4b Srp72 Bcl2 Eif2ak2 Casp8ap2 Arhgdib G6pc Mbd4 Lmnb1 Uso1 Eif2s1 Faslg Bcl2l1 Pkn1 Cast Csnk2b Faf1 Tcp1 LOC100912399 Top1 Tial1 Tia1 Numa1 Csnk1e Casp4 Map3k1 Sptan1 Casp6 Glrx Satb1 Parg Dffa Igf1r Csnk1a1 Stk24 Rfc1 Ube2i Mst1 Stk4 Wee1 Hspb1 Stk3 Cd59 Eif4b Pdcd6 Uba7 Srf Eif3j Lyn Ripk2 Ezr Dedd EPO%IOB%EPO EPO Inpp5d Mapk9 Mapk8 Gsk3a Crkl Plcg1 Shc1 Stat5a Vav1 Stat1 Ptpn11 Rps6ka5 Stat5b Raf1 Nfkbia Akt1 Gsk3b Irs2 LOC100911248 Map2k2 Map2k1 Pik3r2 Nos3 Pik3r1 Mtor Foxo4 Jun Stat3 Epor Gab2 Foxo3 Foxo1 Hcls1 Gab1 Cbl Mst1r LOC100911167 Bcl2l11 Sgk1 Sh2b2 Map4k1 Syk Mapk1 Gata1 Gata4 Lyn Bad CCR1%IOB%CCR1 CCR1 Mapk9 Mapk8 Nfkb1 Ccl5 Ccl4 Ccl7 Creb3 Zap70 Gna14 Ccl3 Ccr1 Mapk14 Stat1 Stat3 Ptk2b Pxn Prkcd Mapk1 Src Ptk2 Jak1 Rela CCR9%IOB%CCR9 CCR9 Mapk8 Mapk14 Foxo1 Jak3 Akt1 Madcam1 Itga4 Cdh1 Rdx Msn Mapk1 Gsk3b Cd226 Ccl25 Itgb7 Ccr9 Ezr Rps6kb1 BDNF%IOB%BDNF BDNF Mapk9 Mapk8 Prkaa2 Plcg1 Shc1 Sirpa Raf1 Akt1 Elk1 Gsk3b Irs2 Irs1 Rps6kb1 Mtor Eif4ebp1 Ntrk1 Frs2 Acacb Foxo3 Ptk2b Frs3 Grin2b Creb1 Grin1 Shc4 Tsc2 Fyn Sh2b2 Kidins220 Mapk1 Ncam1 Igf2bp1 Camk4 Bad Ntrk2 Ngfr Syn1 Tiam1 ID%IOB%ID ID Elk4 Rbl2 Myf6 Rbl1 Psmd4 Smad3 Srebf1 Myf5 Atf3 Hes1 Id1 Elk1 Id3 Id4 Rb1 Pax2 Cdk2 Myog Id2 Elk3 Pax8 Myod1 G-CSF%IOB%G-CSF G-CSF Inpp5d Tec Pla2g1b Lck Fth1 Pom121 Cish Hck Cdkn1b Gsk3a Sod1 Shc1 Stat5a Grb2 Vav1 Mapk14 Stat1 Csf3r Csf3 Ptpn11 Stat5b Il3ra Akt1 Rps6ka1 Notch1 Notch2 Gsk3b Jak1 Csnk1e Nos3 Socs3 Prkci Stat3 Gab2 Cbl Syk Mapk1 Cdk2 Bad Lyn CXCR4%IOB%CXCR4 CXCR4 Grk6 Inpp5d Gnai1 Nfkb1 Itk Cxcl12 Arrb2 Rps6ka2 Ackr3 Ptprc Lcp2 Vcam1 Itgb2 Cxcr4 Ccr5 Icam1 Pim1 Esr2 Raf1 Nfkbia Jak3 Rasa1 Elk1 Pxn Itga4 Prkcz Gsk3b Src Map2k2 Map2k1 Pik3r2 Cfl1 Pik3r1 Egfr Ptk2b Creb1 Cbl Ptpn6 Cblb Fyn Sdc4 Vav2 Prkcd Mapk1 Syk Limk1 Ikbkb Gna13 Chuk Fyb Ptk2 Tff2 Bad Usp14 Pak1 Rela Nfkbib Lck Crk Atf1 Nck1 Rps6 LOC100911372 Crkl Plcg1 Zap70 Vav1 Stat1 Ptpn11 Stat5b Akt1 Ywhab Rps6ka3 Rhoa Bcar1 Dok1 Rac1 Jak1 LOC100911248 Rps6kb1 Socs1 Socs3 Stat3 Foxo3 Foxo1 Stat2 Lyn TNFSF1%IOB%TNFSF1 TNFSF1 Tnfrsf1a Nfkbia Nfkb1 Traf3 Akt1 Nfkb2 Ltbr Lta Tnfrsf1b Tnfrsf14 Jun Rela CCR7%IOB%CCR7 CCR7 Cfl1 Mapk9 Mapk8 Mtor Map2k4 Plcg1 Mapk14 Foxo3 Foxo1 Ptk2b Ccl21 Akt1 Ccr7 Mapk1 Gsk3b Mapk10 Adrb2 Ccl19 Rela Rps6kb1 GDNF%IOB%GDNF GDNF Crk Atf1 Plcg1 Shc1 Raf1 Nfkbia Akt1 Rps6ka3 Pxn Bcar1 Dok1 Src Cdc25c Dok2 Th Map2k2 Map2k1 Rps6kb1 Dok6 Pik3r1 Ret Dok4 Jun Gab2 Ptk2b Gab1 Creb1 Cbl Fyn Cblb Mapk1 Ptk2 Cdk1 WNT%IOB%WNT Wnt Wnt9a Mapk8 Sfrp1 Wnt9b Sfrp2 Ilk Arrb2 Wnt6 Gsk3a Frzb Lrp6 Chrna7 Lrp1 Ppp2ca Ryk Lrp5 Wnt3 Wnt1 Wnt4 Wnt11 Raf1 Ctbp2 Apc Cdh1 Cdh2 Gsk3b Ror2 Rspo2 Src Rspo3 Pparg Sfrp4 Jup LOC364561 Axin2 Ror1 Rspo1 Dvl1 Btrc Ppp1r1b Wnt7b Fzd1 Wnt7a Arrb1 Ccnd1 Dvl3 Fzd9 Nlk Pin1 Prkaca Prkcb Ppp1ca Prkca Nfatc2 Arhgef4 Wnt5a Jun Wnt5b Mark2 Wnt3a Mesdc2 Dab2 Pi4k2a Pip5k1b Daam1 Chd7 Csnk1d Prkch Prkcd Mapk1 Fzd6 Dkk1 Fzd4 Dixdc1 Map3k7 Fzd5 Tcf4 Fzd2 Wif1 Prkcq Map2k4 Akt1 Ywhab Rhoa Yes1 Smad1 Rac1 Pax2 LOC100912399 Lef1 Csnk1e Map3k1 Ctbp1 Csnk1a1 Map3k4 Cdk6 CD40%IOB%CD40 CD40 Mapk9 Mapk8 Pik3r1 Lck Mapk14 Stat1 Traf2 Jun Stat3 Birc3 Fgr Nfkbia Jak3 Traf3 Akt1 Fyn Syk Stat6 Mapk1 Ikbkb Chuk Myc Lyn Map2k1 GM-CSF%IOB%GM-CSF GM-CSF Mapk9 Mapk8 Rps6ka2 Ptprc Gsk3a Mapk14 Kit Raf1 Nfkbia Jak3 Elk1 Pxn Pdia3 Casp8 Gsk3b Tgfbr3 Map2k2 Map2k1 Pik3r2 Pik3r1 Ephb2 Prkca Stam2 Gab1 Creb1 Nfkb2 Cbl Ptpn6 Sh2b2 Mapk1 Syk Ywhaz Ikbkb Chuk Parp1 Bad Tec Map2k6 Pla2g4a Hck Stam Tgfb1 Crkl Plcg1 Shc1 Stat5a Grb2 Vav1 Stat1 Ptpn11 Stat5b Akt1 Bcar1 Yes1 Irs2 Jak1 LOC100911248 Rps6kb1 Csf2rb Cct5 Sptan1 Dpysl2 Pfn1 Csf2 Mad2l1 Ganab Park7 Stat3 Foxo3 Prdx3 Slc2a1 Fes Lyn Ezr IFN-GAMMA%IOB%IFN-GAMMA IFN-gamma Prkcq Mapk8 Crk Rps6 Pla2g4a LOC100911372 Crkl Stat5a Vav1 Mapk14 Stat1 Stat5b Raf1 Akt1 Gsk3b Stat6 Src Jak1 LOC100911248 Prkaca Map3k11 Ifngr1 Jun Irf2 Irf1 Spi1 Egfr Stat3 LOC100909443 Ptk2b Irf8 Stat2 Hoxa11 Eif4b Creb1 Mapk11 Cbl Prkcd Mapk1 ANDROGENRECEPTOR%IOB%ANDROGENRECEPTOR AndrogenReceptor Brca1 Ccne1 Runx2 Casp1 Ncoa1 Hdac1 Casp8 Ccnd1 Ppp1ca Jun Hdac1l Pias2 Pias1 Parp1 Rb1 Tcf4 Rela Cdc25a Sin3a Prkd1 Ncor2 Akt1 Esr1 Daxx Park7 Rchy1 Cdk7 Cdc37 Nsd1 Arnt Slc25a4 Hsp90b1 Cdk9 Psmc3ip Bag1 Whsc1 Nrip1 Spdef Tgfb1i1 Dapk3 Sf1 LOC686349 Sp1 Brinp1 Senp1 Aes Flna Foxa1 Pxn Svil Rbak Gsk3b Rnf4 Pten Src Cdc25b Vip LOC103692716 Nr2c1 Nr2c2 Hipk3 Pias4 Magea11 Pik3r1 Smad3 Gsn Egfr Casp3 Ar Xrcc5 Xrcc6 Plagl1 Prmt1 Ahr Fhl2 Pias3 Cebpa Top1 Tgif1 Ddc Pou2f1 Gtf2h1 Il6st Pnrc1 Etv5 Lpxn Uxt Ccnd3 Nr0b2 Pa2g4 Ube2i Pelp1 Ran Hspa5 Mdm2 Nono Hspb1 Cox5b Stat3 Foxo1 Ncoa2 Ncoa4 Runx1 Ccnh Prdx1 Efcab6 Calr Kat7 Kat5 Zmiz1 Zmiz2 Pak6 Ncoa6 Gtf2f1 Gtf2f2 TNFALPHA%IOB%TNFALPHA TNFalpha Mapk9 Mapk8 Nfkb1 Fadd Psmc1 Psmc2 Bax Smarca4 Mapk14 Traf4 Pml Traf2 Ube2d3 Psmc3 Glg1 Casp2 Nfkbia Bid Hdac1 Tradd Casp8 Nkiras2 Btrc Inpp5e Irak1bp1 Rasal2 Polr1c Polr1a Polr1b Hdac2 Nlrp4 Kpna2 Kpna3 Pdcd2 Ddx3x Tnip2 Polr1e Jun Nkiras1 Mark2 Tab2 Smarcb1 Rpl4 Hdac1l Ripk3 Gab1 Fbl Creb1 LOC100912534 Traf7 Fancd2 Traf6 Cflar Cops3 Psmd1 Syk Mapk1 Map3k8 Csnk2a1 Psmd7 Rb1 Map3k7 Psmd6 Mlc1 Ripk1 Psmd3 Psmd2 Rela Azi2 Ywhae Ptpn11 Akt1 Ywhab Crebbp Ywhah Cul1 Traf3 Skp1 Cdc37 Cdk9 Tp53 Brinp1 Flna Prkcz Src Map2k5 Mapkapk2 LOC103692716 Nr2c2 Map2k1 Map3k11 Egfr Tnfrsf1a Casp3 Nfkb2 Map3k14 Tnfrsf1b Prkcd Tnfrsf8 Ywhaz Ikbkb Chuk Ptk2 Nfkbib Unc5cl Papola Map2k6 Psmb5 Ywhag Usp2 Akt2 Rps11 Rpl30 Rps13 Fkbp5 Pias3 Stat5a Zfand5 Kpna6 Spag9 Stat1 Trib3 Glb1 Rps6ka5 Smarcc2 Smarcc1 Tifa Rnf25 Tbkbp1 Psmd12 Cradd Ikbkap RGD1565904 Pkn1 Nfkbiz Hdac6 Dok1 Faf1 Nfkbie Dpf2 LOC100912399 Nsmaf Tank Usp11 Rasa3 Rps6kb1 Psmd13 Ppp6c Map3k2 Alpl Map3k1 Kcnq1 Map3k3 Mcm7 Birc2 Gtf2i LOC684988 Actl6a Lrpprc Akap8 Dcaf7 Bag4 Ube2i Polr2h Ikbke Hspa5 Mylk Hsp90ab1 Hspb1 Fbxw11 G3bp2 Trpc4ap Tnfrsf11a Smarce1 Prc1 Hspa1b Hspa1a Pfdn2 Mcm5 Mtif2 Tbk1 HEDGEHOG%IOB%HEDGEHOG Hedgehog Sdc2 Arrb2 Sin3a Ywhae Rab23 Sap18 RGD1561590 Kif7 Akt1 Sufu Ihh Boc Cdon Crebbp Med12 Smad1 Gli1 Gli2 Dhh Ptch1 Shh Kif27 Med1 Prkaca Hhip Med6 Med23 Stk36 Smo Dyrk1a Adrbk1 KITRECEPTOR%IOB%KITRECEPTOR KitReceptor Inpp5d Mapk8 Mitf Sh3kbp1 Gsk3a Atf2 Mapk14 Actr2 Kit Raf1 Fgr Jak3 Rasa1 Elk1 Gsk3b Src Map2k2 Map2k1 Pik3r2 Pik3r1 Mtor Eif4ebp1 Prkcb Prkca Nfatc2 Abl1 Jun Grb10 Grb7 Gab2 Gys1 Epor Lat Grap Stap1 Matk Cbl Ptpn6 Spred1 Fyn Wipf1 Cblb Mpdz Sh2b2 Mapk1 Hras Spred2 Bad Cltc Pak1 Rela Socs5 Tec Fer Crk Socs6 Kitlg Rps6 Hck Ptpru LOC100911372 Socs4 Crkl Plcg1 Shc1 Stat5a Grb2 Vav1 Stat1 Ptpn11 Stat5b Akt1 Rps6ka1 Dok1 Yes1 LOC100909750 LOC100911248 Sos1 Rps6kb1 Csf2rb Socs1 Mad2l1 Stat3 Fes Lyn BIOCARTA_IL5_PATHWAY%MSIGDB_C2%BIOCARTA_IL5_PATHWAY BIOCARTA_IL5_PATHWAY Il4 Il5 RT1-Db1 Il6 Ccr3 Il1b Cd4 Il5ra Ccl11 RT1-Da HALLMARK_G2M_CHECKPOINT%MSIGDB_C2%HALLMARK_G2M_CHECKPOINT HALLMARK_G2M_CHECKPOINT Npap60 Mad2l1 Casc5 Syncrip Ewsr1 Mapk14 Sqle Tmpo Espl1 Cenpa LOC100912481 Katna1 Smc4 Kif5b Smc2 Hist1h2bk Ndc80 Cdkn1b Ilf3 Top1 Srsf1 Bard1 Ctcf Numa1 Kif4a Dr1 Cul3 Slc12a2 Traip Cdkn3 Tgfb1 Mnat1 Suv39h1 Mcm3 Mcm5 Mt2A Mcm6 LOC100909750 Incenp Pafah1b1 Prc1 E2f3 Tle3 Tpx2 E2f1 Rad23b Mcm2 Cdk4 Nolc1 Mybl2 Cdc6 Cdc7 Cks2 Cdk1 Meis2 Casp8ap2 Mki67 Ttk LOC100909949 Kif2c Whsc1 Hnrnpu Cdc20 Cdc27 Ube2c Racgap1 Pttg1 Mtf2 Fancc Pbk Ube2s Rbl1 Myc Ccnd1 Orc6 Stt3a Orc5 Smarcc1 Cdkn2c Papd7 Ccnf Hmmr Hn1 Cul4a Stag1 Tnpo2 Kif20b Snrpd1 Kpna2 Prpf4b Chaf1a Ezh2 Slc38a1 Xpo1 Tra2b Kif23 Bub1 Ythdc1 Cul5 LOC686349 Smad3 Cul1 Dtymk Lmnb1 Aurka Atf5 Hif1a Hnrpd H2afx H2afz Aurkb Tacc3 Srsf2 Suv39h1l1 Ccna2 Fbxo5 Hira Cdc25b Cenpf Cdc25a Smc1a Arid4a Cenpe Odc1 Nup98 Ddx39a Nusap1 Rad21 Rpa2 Gspt1 Setd8 Plk4 Cks1l Prim2 Hus1 Amd1 Plk1 Prmt5 Pml Brca2 Polq Hoxc10 Foxn3 Kif11 Sfpq Slc7a5 LOC100362620 Pola2 Ss18 Hmgb3 Cdc45 Stmn1 Lig3 Kif15 Abl1 Chmp1a Slc7a1 Notch2 Nasp LOC100911837 Pole Kpnb1 Rasal2 Kif22 Hmga1 Rps6ka5 G3bp1 Meis1 Pds5b Uck2 Cks1b Gins2 PID_E2F_PATHWAY%MSIGDB_C2%PID_E2F_PATHWAY PID_E2F_PATHWAY Smarca2 Tyms Serpine1 Cebpa Ces4a Brca1 Tfdp2 Yy1 Hbp1 Plau Sp1 Rbbp8 Ces5a Tp73 Cdkn1a Hdac1l Cdkn1b Ccne1 Ccne2 Rrm2 RGD1565297 Hdac1 Tfe3 E2f5 Cdk2 Mcm3 Rb1 E2f6 Prmt5 Ranbp1 Xrcc1 Uxt Wasf1 E2f3 E2f1 Atm Sult2a1 Mybl2 Ces1d Cdc6 Crebbp Cbx5 Cdkn2a Cdk1 Apaf1 Orc1 Ccnd3 Kat2a Rbl2 Topbp1 Trim28 Ces2h E2f7 Dhfr Rbl1 Myc Cdkn2c Ccna2 Cdc25a ST_GAQ_PATHWAY%MSIGDB_C2%ST_GAQ_PATHWAY ST_GAQ_PATHWAY Pik3cb C2 Itpr1 Itpka Itpr3 Pld3 Pld2 Pld1 Itpkb Gnaq Nfkb2 Nfkb1 Pdk1 Akt2 Akt3 Tonsl Akt1 Nfkbil1 Dag1 Pitx2 Nfkbia Nfkbie Nfkbib Vom1r53 Adrbk1 PID_MTOR_4PATHWAY%MSIGDB_C2%PID_MTOR_4PATHWAY PID_MTOR_4PATHWAY Yy1 Pld2 Pld1 Ywhae Ccne1 Rragc Eef2 Rhoa Eif4b Rragd Akt1 Sgk1 Mapkap1 Cdk2 Rb1cc1 Ppargc1a Ywhab Pml Atg13 Rraga Fbxw11 Poldip3 Raf1 Ywhah Rac1 Mapk1 Ywhag Irs1 Nras Rps6kb1 Ikbkb Ywhaz Cycs Ulk2 Eef2k Ulk1 Sspo Prkca Rps6ka1 Mlst8 Tsc1 Tsc2 Pdcd4 Akt1s1 Eif4a1 Mtor Ddit4 Pxn Hras Eif4ebp1 RragB Srebf1 Rictor Prr5 LOC100910121 Pdpk1 Rrn3 Map2k1 Map2k2 Bnip3 Rptor Sfn Kras PID_IL8_CXCR2_PATHWAY%MSIGDB_C2%PID_IL8_CXCR2_PATHWAY PID_IL8_CXCR2_PATHWAY Pdpk1 Pld2 Akt1 Fgr Prkcb Dnm1 Hck Pik3cg Plcb1 Ppp2ca Ppp2r1a Plcb2 Gna14 Cbl Gna15 Rac2 Pik3r6 Arrb2 Lyn Gnai2 Plcb3 Arrb1 Cxcr2 Rab11a Prkca Gnb1 Rab7a Vasp PID_CONE_PATHWAY%MSIGDB_C2%PID_CONE_PATHWAY PID_CONE_PATHWAY Gucy2f Gucy2d Gnat2 Lrat Pde6c Gngt2 Slc24a2 Arr3 Rgs9bp Rgs9 Rpe65 Gnb3 Cngb3 Pde6h Gnb5 Guca1b Guca1a Grk1 BIOCARTA_TALL1_PATHWAY%MSIGDB_C2%BIOCARTA_TALL1_PATHWAY BIOCARTA_TALL1_PATHWAY Mapk14 Tnfsf13b Mapk8 Traf2 Traf3 Tnfrsf13c Rela Chuk Tnfsf13 Nfkb1 Map3k14 Traf6 Tnfrsf17 PID_GMCSF_PATHWAY%MSIGDB_C2%PID_GMCSF_PATHWAY PID_GMCSF_PATHWAY Hras Prkaca Fos Gab2 Prkacb Map2k1 Csf2 Sos1 Map2k2 Syk Ccl12 Stat5b Osm Pim1 Shc1 Csf2rb Irf8 Cish Stat5a Kras Stat1 Inpp5d Stat3 Ptpn11 Pik3r1 Raf1 Grb2 Mapk1 Nras Ikbkb Ywhaz Lyn PID_NEPHRIN_NEPH1_PATHWAY%MSIGDB_C2%PID_NEPHRIN_NEPH1_PATHWAY PID_NEPHRIN_NEPH1_PATHWAY Pik3cb F2rl2 Plcg1 Cd2ap Mapk10 Bad Prkcz Nphs2 Nphs1 Akt1 Pik3r2 Nck1 Pik3r1 Pik3r3 Map2k4 Mapk9 Nck2 Pard6a Kirrel Jun Fyn Rac1 Pik3cd Grb2 Prkci Trpc6 Tjp1 Mapk8 Arrb2 HALLMARK_PEROXISOME%MSIGDB_C2%HALLMARK_PEROXISOME HALLMARK_PEROXISOME Ywhah Smarcc1 Slc27a2 Dhrs3 Gnpat Lonp2 Idh1 Idh2 Abcb1a Mlycd Ercc1 Ercc3 Rxrg Elovl5 Siah1 Fis1 Prdx1 Prdx5 Eci3 Sema3c LOC100910173 Ephx2 Hao2 Pex6 Ech1 Cadm1 Pabpc1 Alb Abcc5 Abcc8 Cacna1b Slc35b2 Fads1 Slc23a2 Ugt2b Vps4b Rdh11 Retsat Sod2 Sod1 Pex2 LOC100360417 Ide Abcb9 Dio1 Isoc1 Aldh1a1 Idi1 Nr1i2 Atxn1 Hsd11b2 Scgb1a1 Ehhadh Hsd17b11 Aldh9a1 Crat Ugt2b15 Abcd1 Scp2 Slc25a4 Cat Dlg4 Ttr Msh2 Tspo Serpina6 Fdps Fabp6 Crabp1 Hsd17b4 Acox1 Mvp Cel Hmgcl Cln8 Dhcr24 Cln6 Pex11a Pex11b Ugt2b37 Abcd2 Slc25a17 Abcd3 Ctps1 Hras Sult2b1 Cnbp Gstk1 Acsl1 Acsl5 Acot8 Sts Acsl4 Pex14 Cdk7 Hsd3b7 Pex13 Slc25a19 Ctbp1 Bcl10 Esr2 PID_ERA_GENOMIC_PATHWAY%MSIGDB_C2%PID_ERA_GENOMIC_PATHWAY PID_ERA_GENOMIC_PATHWAY Brca1 Hdac1l Sod1 Hdac1 Ncoa7 Nedd8 Nr0b1 Anp32a Nrip1 Pgr Prl C3 Ncoa1 Ncoa2 Uba3 Mpg Sra1 Pcna Phb2 Pou4f2 Ap1b1 Axin2 Lmo4 Ddx54 Ncor2 Abca3 Safb Apbb1 Mta1 Chuk Col18a1 Set Tff1 Cd82 Calcoco1 Ctsd Hdac4 Myc Ccnd1 Hsf2 Esr1 Med1 Stat5a Nr0b2 Atp5j Prdm15 Xbp1 Ndufv3 Ube2m Ebag9 Esr2 Dscam Jun PID_ARF_3PATHWAY%MSIGDB_C2%PID_ARF_3PATHWAY PID_ARF_3PATHWAY Cd4 Rac1 Arfgap1 Arfip2 Gga3 Pld2 Clta Cltb Uso1 Kdelr1 Asap1 Ap2m1 Gosr2 Cyth2 Ap2a1 Gbf1 PID_ECADHERIN_NASCENT_AJ_PATHWAY%MSIGDB_C2%PID_ECADHERIN_NASCENT_AJ_PATHWAY PID_ECADHERIN_NASCENT_AJ_PATHWAY Klhl20 Ccnd1 Rhoa Akt1 Csnk2a1 Csnk2b Pik3r1 Iqgap1 Csnk2a2 Ap1m1 Jup Cttn Vav2 Ctnna1 Enah Nckap1 Rac1 Dlg1 Itgb7 Tiam1 Crk Tjp1 Nme1 Pip5k1c Cdh1 Ctnnd1 Src Abi1 Rap1b Arf6 Rap1a BIOCARTA_CACAM_PATHWAY%MSIGDB_C2%BIOCARTA_CACAM_PATHWAY BIOCARTA_CACAM_PATHWAY Camk2a Creb1 Camkk2 Camk1g Camk1 Camkk1 Camk2d Camk2g Camk4 BIOCARTA_MYOSIN_PATHWAY%MSIGDB_C2%BIOCARTA_MYOSIN_PATHWAY BIOCARTA_MYOSIN_PATHWAY Prkcb Mylk Plcb1 Arhgef3 Arhgef2 Arhgef6 Gngt1 Arhgef7 Myl7 Arhgef4 Gna12 Gna13 Arhgef5 Rock1 Prkca Gnaq Arhgef18 Gnb1 Arhgap5 Arhgef11 Arhgef15 Pkn1 Arhgef19 HALLMARK_CHOLESTEROL_HOMEOSTASIS%MSIGDB_C2%HALLMARK_CHOLESTEROL_HOMEOSTASIS HALLMARK_CHOLESTEROL_HOMEOSTASIS Aldoc Lgals3 Stx5 Clu Tmem97 Nsdhl Atf3 Sqle Cyp51 Ech1 Fbxo6 Anxa13 Srebf2 Mvd Adh4 Fabp5 Pmvk Pnrc1 Cbs Avpr1a Tp53inp1 Ethe1 Cpeb2 Hmgcr Scd1 Pcyt2 Abca2 Ebp LOC100360417 Gldc Jag1 Alcam Tnfrsf12a Pdk3 Chka Idi1 Gnai1 Plscr1 Stard4 Tm7sf2 LOC100361457 Ldlr Sc5d Fam129a Atxn2 Actg1 Nfil3 Hmgcs1 Acat2 Lpl Dhcr7 Gstm7 Hsd17b7 Fdps Pparg Mal2 Fdft1 Acss2 RGD1562948 Anxa5 Gusb Sema3b Trib3 Gpx8 Lgmn Cxcl16 Atf5 SA_G1_AND_S_PHASES%MSIGDB_C2%SA_G1_AND_S_PHASES SA_G1_AND_S_PHASES Cdk2 Cdkn1b Cdkn2a Ccnd1 Tp53 E2f1 Mdm2 Cfl1 Cdkn1a Nxt1 Cdk4 Prpmp5 BIOCARTA_MPR_PATHWAY%MSIGDB_C2%BIOCARTA_MPR_PATHWAY BIOCARTA_MPR_PATHWAY Hras Prkacb Myt1 Prkar2b Prkar2a Cdc25c Gnai1 Actr3 Arpc4 Arpc5 Paqr7 Prkar1b Paqr5 Pgr Acta1 Pin1 LOC364561 Arpc3 Arpc2 Mapk1 Cap1 Arpc1b Actr2 Gngt1 Src Cdk1 Gnb1 Rps6ka1 BIOCARTA_IL12_PATHWAY%MSIGDB_C2%BIOCARTA_IL12_PATHWAY BIOCARTA_IL12_PATHWAY Mapk14 Jun Il12rb2 Map2k6 Mapk8 Etv5 Cd3g Ccr5 Cxcr3 Il12a Ifng Cd247 Il12b Il18r1 Stat1 Cd3d Il18 Cd3e BIOCARTA_AT1R_PATHWAY%MSIGDB_C2%BIOCARTA_AT1R_PATHWAY BIOCARTA_AT1R_PATHWAY Hras Map2k1 Sos1 Map2k2 Mef2c Agt Atf2 Shc1 Map3k1 Gnaq LOC100912399 Ptk2b Pak1 Egfr Elk1 Agtr1a Ptk2 Map2k4 Prkcb Mef2d Jun Raf1 Rac1 Mapk1 Grb2 Mapk8 Src Prkca BIOCARTA_CHEMICAL_PATHWAY%MSIGDB_C2%BIOCARTA_CHEMICAL_PATHWAY BIOCARTA_CHEMICAL_PATHWAY Casp6 Bid Pxn Casp9 Casp3 Bax Prkcb Bcl2 Eif2s1 Parp1 Tp53 Tln1 Atm Cycs Apaf1 Prkca Stat1 Bad Bcl2l1 Ptk2 Akt1 BIOCARTA_CXCR4_PATHWAY%MSIGDB_C2%BIOCARTA_CXCR4_PATHWAY BIOCARTA_CXCR4_PATHWAY Gnai1 Pxn Pik3r1 Hras Prkcb Raf1 Map2k1 Mapk1 Crk Gngt1 Bcar1 Pik3c2g Cxcr4 Rela Prkca Gnaq Plcg1 Gnb1 Nfkb1 Cxcl12 Ptk2b Ptk2 HALLMARK_KRAS_SIGNALING_DN%MSIGDB_C2%HALLMARK_KRAS_SIGNALING_DN HALLMARK_KRAS_SIGNALING_DN Gprc5c Tnni3 Fgf22 Calca Cpa2 Adck3 Mast3 Bard1 Sgk1 Gp1ba Itih3 Msh5 Cdh16 LOC100912306 Clps Tex15 Zfp112 Ccr8 Skil Gtf3c5 Tgm1 LOC100911478 Upk3b Ribc2 Cacng1 Cldn8 Slc5a5 Gp2 Tshb Vpreb2 Cntfr Tfcp2l1 Btg2 Asb7 Tas2r108 Tenm2 Nr4a2 Plag1 Sstr4 Cdkal1 Lgals7 LOC100912928 Nos1 Smpx Atp4a P2ry4 Serpina10 Wnt16 Prop1 Klk8 Ntf3 Sox10 Cd40lg Ybx2 Kcnq2 Ugt2b Slc25a23 Edar Pax4 Pax3 Ifi44l Cldn16 Sncb Efhd1 Lypd3 Dtnb Serpinb2 Tcl1a Ngb Nphs1 Celsr2 Igfbp2 Hsd11b2 Zc2hc1c Scgb1a1 Abcg4 Cd207 P2rx6 LOC100909899 LOC100909761 Ugt2b15 Actc1 Thnsl2 Krt15 Mefv Hnf1a Slc38a3 Fggy Mx2 Klk7 Pdk2 Tgfb2 Tlx1 Krt4 Clstn3 Snn Fam46c Gamt Krt1 Oxt Gpr3 Nr6a1 Ccna1 Grid2 Ugt2b37 Prodh Itgb1bp2 Kcne2 Il5 Arpp21 Pkp1 Entpd7 Slc16a7 Krt13 Fgfr3 Mthfr Magix Pcdhb1 Scn10a Edn1 Edn2 Dlk2 Stag3 Nudt10 Nudt11 Gdnf Fshb Cacna1f Rsad2 Slc6a14 Ptprj Cpb1 Kcnd1 Alox12b Myh7 Slc6a3 Ckm Akr1b8 Adra2c Tcf7l1 Cyp39a1 Cyp11b2 Tff2 Slc30a3 Htr1b Kcnmb1 Thrb Cd80 Sphk2 Lfng Ambn Dcc Ccdc132 Capn9 H2afy2 Pde6b Myot Mfsd6 Cpeb3 Ptgfr Kcnn1 Pdcd1 Gpr19 Slc29a3 Htr1d Ifng Synpo Fgf16 Il12b Klhdc8a Zbtb16 Tfap2b Tg BIOCARTA_IL4_PATHWAY%MSIGDB_C2%BIOCARTA_IL4_PATHWAY BIOCARTA_IL4_PATHWAY Rps6kb1 Il4 Stat6 Shc1 Jak3 Il4r Jak1 Il2rg Grb2 Irs1 Akt1 BIOCARTA_TCR_PATHWAY%MSIGDB_C2%BIOCARTA_TCR_PATHWAY BIOCARTA_TCR_PATHWAY Hras Fos Map2k1 Sos1 Shc1 Rasa1 Nfatc2 Map3k1 Ptpn7 LOC100912399 Plcg1 Nfatc4 Nfkb1 Nfatc3 Vav1 Elk1 Lat Ppp3ca Lck Pik3r1 Map2k4 Prkcb Ppp3cb Zap70 Pik3cg Jun Raf1 Fyn Nfkbia Rac1 Grb2 Mapk8 Cd3g Rela Prkca Cd247 Cd3d Cd3e BIOCARTA_G2_PATHWAY%MSIGDB_C2%BIOCARTA_G2_PATHWAY BIOCARTA_G2_PATHWAY Atr Plk1 Brca1 Tp53 Ywhah Stt3a Prkdc Mdm2 Wee1 Gadd45a Cdkn1a Chek2 Atm Myt1 Cdk1 Cdc25b Cdc25c Cdc25a Rps6ka1 BIOCARTA_NO1_PATHWAY%MSIGDB_C2%BIOCARTA_NO1_PATHWAY BIOCARTA_NO1_PATHWAY Prkar1b Acta1 Prkacb Tnni1 Pde2a Vegfa Prkg2 Prkar2b Prkar2a Flt1 Slc7a1 Pde3b Chrna1 LOC103692716 Pde3a Bdkrb2 Flt4 Chrm1 Nos3 LOC100911280 Akt1 BIOCARTA_GRANULOCYTES_PATHWAY%MSIGDB_C2%BIOCARTA_GRANULOCYTES_PATHWAY BIOCARTA_GRANULOCYTES_PATHWAY Csf3 Itgam Selplg Itgb2 Ifng Icam1 Il1a Itgal Selp PID_ECADHERIN_KERATINOCYTE_PATHWAY%MSIGDB_C2%PID_ECADHERIN_KERATINOCYTE_PATHWAY PID_ECADHERIN_KERATINOCYTE_PATHWAY Pik3r1 Jup Ctnna1 Fyn Rac1 Cdh1 Ctnnd1 Src Casr Plcg1 Ajuba Rhoa Vasp Akt2 Egfr Zyx Akt1 ST_TYPE_I_INTERFERON_PATHWAY%MSIGDB_C2%ST_TYPE_I_INTERFERON_PATHWAY ST_TYPE_I_INTERFERON_PATHWAY Reg1a Stat2 Irf9 Jak1 Ifnb1 Ptpru Ifnar1 Stat1 ST_GA13_PATHWAY%MSIGDB_C2%ST_GA13_PATHWAY ST_GA13_PATHWAY Pik3cb Bcl2 Rdx Rock2 C2 Srf Prkd1 Tbxa2r Serpina4 Pld3 Pld2 Pld1 Map3k1 LOC100912399 Nfkb2 Nfkb1 Pdk1 Akt2 Akt3 Tonsl Ptk2 Akt1 Map2k4 Nfkbil1 Nfkbia Nfkbie Dlg4 Nfkbib Mapk8 Gna13 Rock1 Arhgef11 BIOCARTA_PITX2_PATHWAY%MSIGDB_C2%BIOCARTA_PITX2_PATHWAY BIOCARTA_PITX2_PATHWAY Ldb1 Wnt1 Med1 Apc Crebbp Fzd1 Lef1 Gsk3b Dvl1 Pitx2 Hdac1 Hdac1l PID_RAC1_PATHWAY%MSIGDB_C2%PID_RAC1_PATHWAY PID_RAC1_PATHWAY Mapk14 Wasf1 Rac1 Mapk8 Bcar1 Arhgap5 Racgap1 Cfl1 Atf2 Stat5a Map3k1 LOC100912399 Pak1 Stat3 Actr3 Ncf2 Ncf1 Arpc4 Iqgap1 Arhgdia Arpc5 Noxo1 Map2k4 Pak2 Pip5k1b Mapk9 Limk1 Noxa1 Iqgap3 Ctnna1 Map3k11 Jun Brk1 Nckap1 Map2k7 Arpc3 Plcb2 Cybb Arpc2 Abi2 Cyba Crk Arpc1b Actr2 Baiap2 Pip5k1c Cdh1 Map2k6 Abi1 PID_TRAIL_PATHWAY%MSIGDB_C2%PID_TRAIL_PATHWAY PID_TRAIL_PATHWAY Smpd1 Pik3r2 Tradd Pik3cb Pik3r1 Ripk1 Pik3r3 Tnfsf10 Fadd Map2k4 Dap3 Cflar Pik3cd Mapk1 Casp8 Mapk8 Ikbkb Traf2 Chuk Map3k1 LOC100912399 PID_P53_REGULATION_PATHWAY%MSIGDB_C2%PID_P53_REGULATION_PATHWAY PID_P53_REGULATION_PATHWAY Mapk14 Yy1 Gsk3b Setd8 Akt1 Atr Nedd8 Cdk2 Prmt5 LOC100909750 Prkcd Chek2 Atm Mapk8 Crebbp Abl1 Cdkn2a LOC100909949 Trim28 Setd7 Tp53 Ube2d1 Fbxo11 Stt3a Mdm2 Skp2 E4f1 Daxx Mdm4 Rchy1 Mapk9 Dyrk2 Csnk1a1 Ccng1 Pin1 Ppp2ca LOC364561 Usp7 Smyd2 Csnk1d Ccna2 Csnk1g1 Kat5 Kat8 Csnk1g2 Rassf1 Hipk2 Ppm1d Rpl11 Ppp2r4 Rpl23 Cse1l Ttc5 Csnk1g3 Csnk1e PID_ALPHA_SYNUCLEIN_PATHWAY%MSIGDB_C2%PID_ALPHA_SYNUCLEIN_PATHWAY PID_ALPHA_SYNUCLEIN_PATHWAY Syk Pld2 Pld1 Ptk2b Bad Slc6a3 Lck Csnk2a1 Park7 Maob Th Ube2l3 Fgr Prkcd Hck Uchl1 Sncaip Snca Fyn Blk Klk6 Mapk1 Plcb2 Yes1 Fkbp1a Tor1a Src Lyn Grk5 BIOCARTA_SODD_PATHWAY%MSIGDB_C2%BIOCARTA_SODD_PATHWAY BIOCARTA_SODD_PATHWAY Bag4 Tnfrsf1b Tradd Ripk1 Traf2 Fadd Birc3 Tnfrsf1a Casp8 PID_CMYB_PATHWAY%MSIGDB_C2%PID_CMYB_PATHWAY PID_CMYB_PATHWAY Smarca2 Cebpa Sp1 Cdkn1a Cdkn1b Wnt1 Lef1 Nlk Anpep Atp2b1 Cd34 Slc25a3 Maf LOC100363915 Myf6 Ptgs2 Map3k7 Car1 Ppidl1 LOC100911324 Hes1 Tab2 Nras Mpo Gstm7 Crebbp Cdkn2a Trim28 Pias3 Tom1 Ccna1 Csf1r Kit Gata1 Casp6 Gata3 Kitlg Mat2a Hras Ets1 Myod1 Bcl2 Snd1 Cd4 Elane Myc Sin3a Ccnd1 Birc3 Ets2 Yeats4 Ptcra Lect2 Zfhx3 Cbx4 Pim1 Adora2b Col1a2 Rag2 Prtn3 Mad1l1 Kras Mcm4 Ube2i Ada Cdk6 Ppp3ca LOC100911167 Spi1 Iqgap1 H2afz Clta Hipk2 PID_AR_PATHWAY%MSIGDB_C2%PID_AR_PATHWAY PID_AR_PATHWAY Lats2 Prdx1 Svil Zmiz1 Pias1 Tcf4 Mak Brca1 Hip1 Vav3 Tgif1 Fhl2 Kdm1a Casp8 Pias4 Fkbp4 Snurf Kdm3a Nkx3-1 Pa2g4 Pawr Pelp1 Ube3a Tgfb1i1 Ncoa6 Carm1 Rps6ka3 Tmprss2 Gsn Ncoa4 Ar Akt1 Nrip1 Xrcc6 Ncoa2 Ctdsp1 Uba3 Xrcc5 Zfp318 Prkdc Cdkn2a Ccnd3 Pias3 Ccnd1 Srf Med1 Ptk2b Ube2i Cdk6 BIOCARTA_RANKL_PATHWAY%MSIGDB_C2%BIOCARTA_RANKL_PATHWAY BIOCARTA_RANKL_PATHWAY Mapk8 Irf9 Ifnb1 Ifnar1 Rela Fos Nfkb1 Traf6 Eif2ak2 Fosl1 Tnfrsf11a BIOCARTA_HDAC_PATHWAY%MSIGDB_C2%BIOCARTA_HDAC_PATHWAY BIOCARTA_HDAC_PATHWAY Pik3r1 Igf1r Ins2 Mapk14 Cabin1 Myod1 Insr Ppp3cb Igf1 Mef2d Pik3cg Ywhah Map2k6 Mef2c Camk1g Camk1 Nfatc2 Ppp3ca Akt1 SIG_CD40PATHWAYMAP%MSIGDB_C2%SIG_CD40PATHWAYMAP SIG_CD40PATHWAYMAP Mapk12 Mapk13 Mapk11 Cd40 Mapk14 Mapk8ip2 Syt1 Mapk8ip3 Mapkapk5 Mapk8ip1 Gorasp1 Dusp1 Nfkb2 Nfkb1 Mapk10 Tonsl Pik3r1 Map2k4 Mapk9 Nfkbil1 Pik3cd Nfkbia Map2k7 Nfkbie Mapk1 Nfkbib Mapk8 Traf2 Traf3 Traf6 BIOCARTA_LEPTIN_PATHWAY%MSIGDB_C2%BIOCARTA_LEPTIN_PATHWAY BIOCARTA_LEPTIN_PATHWAY Prkab1 Cpt1a Lepr Prkaa1 Lep Prkaa2 Prkag2 Prkab2 Prkag3 Leprot BIOCARTA_AGPCR_PATHWAY%MSIGDB_C2%BIOCARTA_AGPCR_PATHWAY BIOCARTA_AGPCR_PATHWAY Gngt1 Prkar1b Prkcb Prkar2b Prkar2a Arrb1 Prkca Gnb1 Prkacb Grk4 PID_TCR_CALCIUM_PATHWAY%MSIGDB_C2%PID_TCR_CALCIUM_PATHWAY PID_TCR_CALCIUM_PATHWAY Il4 Prkaca Fos Csf2 Cd40lg Nfatc2 Nfatc3 Ppp3ca Cabin1 Ppp3cb Ptgs2 Jun Fkbp1a Junb Il2 Chp1 Faslg Ppp3r1 Akap5 Il2ra Batf3 Ifng Pou2f1 Fosl1 Rcan2 PID_EPO_PATHWAY%MSIGDB_C2%PID_EPO_PATHWAY PID_EPO_PATHWAY Hras Ptpn6 Tec Bcl2 Mapk14 LOC100911248 Epo Crkl Gab1 Irs2 Sos1 Epor Socs3 Stat5b Shc1 Stat5a Plcg1 Nfkb1 Stat1 Inpp5d Ptpn11 Pik3r1 Vav2 Grb2 Cbl Trpc6 Mapk8 Lyn Rap1a Bcl2l1 PID_TGFBR_PATHWAY%MSIGDB_C2%PID_TGFBR_PATHWAY PID_TGFBR_PATHWAY Pdpk1 Sos1 Camk2a Shc1 Ywhae Rhoa Tgfb1 Daxx Smad3 Pml Pard6a Dact2 Zfyve9 Map3k7 Skil Wwp1 Ppp2ca Bambi Tgfbrap1 Grb2 Zfyve16 Smad2 Tab2 Smad7 Fkbp1a Tgfb3 Rps6kb1 Dab2 Ppp1ca Tgfb2 Ppp1r15a Arrb2 Strap Xiap Ppp2r2a Tgfbr2 Ctgf Dynlrb1 Tgfbr1 Tgfbr3 Smurf1 Ppp2cb Eif2a Sptbn1 BIOCARTA_PS1_PATHWAY%MSIGDB_C2%BIOCARTA_PS1_PATHWAY BIOCARTA_PS1_PATHWAY Wnt1 Apc Fzd1 Notch1 Adam17 Gsk3b Psen1 Dvl1 Btrc Hnf1a PID_AURORA_B_PATHWAY%MSIGDB_C2%PID_AURORA_B_PATHWAY PID_AURORA_B_PATHWAY Racgap1 Cenpa Smc4 Smc2 Ndc80 Klhl9 Rasa1 Ppp1cc Ncapg Pebp1 Cul3 Rhoa Psma3 Tacc1 Vim Des Kif23 Kif20a Cdca8 Bub1 Npm1 Nsun2 Klhl13 Ncapd2 Sept1 Sgol1 Incenp Aurka Mylk Aurkb Stmn1 Cbx5 Kif2c PID_DELTA_NP63_PATHWAY%MSIGDB_C2%PID_DELTA_NP63_PATHWAY PID_DELTA_NP63_PATHWAY Igfbp3 Ppp2r5a Stxbp4 Dlx5 Notch1 Runx1 Hbp1 Tp63 Itga3 Rab38 Sec14l2 Mdm2 Perp T Axl Gpx2 Krt14 Nrg1 Adrm1 Hells LOC100911660 Gsk3b Col5a1 Rrad Vdr Sfn Bdkrb2 Ada Mre11a Tcf7l1 Brca2 Wwp1 Hes1 Atm Cdkn2a Il1a PID_ANGIOPOIETIN_RECEPTOR_PATHWAY%MSIGDB_C2%PID_ANGIOPOIETIN_RECEPTOR_PATHWAY PID_ANGIOPOIETIN_RECEPTOR_PATHWAY Pxn Ets1 Mapk14 Foxo1 Itgb1 Elf1 Elf2 Cdkn1a Stat5b Shc1 Pld2 Rasa1 Stat5a Nfkb1 Pak1 Elk1 Agtr1a Nos3 Ptpn11 Akt1 Ptk2 Nck1 Pik3r1 Fyn Rac1 Grb2 Mapk1 Crk Rps6kb1 Angpt1 Grb14 Mapk8 Mmp2 Angpt4 Itga5 Grb7 Fgf2 Rela Tnip2 Fes Fn1 F2 Plg Tek Angpt2 Dok2 Bmx SA_FAS_SIGNALING%MSIGDB_C2%SA_FAS_SIGNALING SA_FAS_SIGNALING Pde6d Faslg Endou Casp3 Bcl2 Cflar Fas Cfl1 Casp8 PID_ANTHRAX_PATHWAY%MSIGDB_C2%PID_ANTHRAX_PATHWAY PID_ANTHRAX_PATHWAY Map2k6 Casp1 Map2k4 Pgr Antxr1 Il1b Vcam1 Map2k7 Mapk1 Map2k1 Map2k2 Il18 SA_CASPASE_CASCADE%MSIGDB_C2%SA_CASPASE_CASCADE SA_CASPASE_CASCADE Casp9 Casp3 Srebf1 Parp1 Birc3 Srebf2 Fas Casp8 Dffb Faslg Xiap Apaf1 Birc2 Dffa Scap PID_INSULIN_PATHWAY%MSIGDB_C2%PID_INSULIN_PATHWAY PID_INSULIN_PATHWAY Hras Eif4ebp1 Pdpk1 Sos1 Shc1 Rasa1 F2rl2 Akt2 Inpp5d Prkcz Ptpn11 Akt1 Sgk1 Nck1 Pik3r1 Ins2 Exoc5 Exoc3 Insr Ptpn1 Nck2 Exoc6 Pard6a Grb2 Prkci Cbl Crk Irs1 Foxo3 Rps6kb1 Grb14 Exoc2 Exoc7 Grb10 Dok1 Rhoq Sh2b2 Ptpra Sorbs1 BIOCARTA_RHO_PATHWAY%MSIGDB_C2%BIOCARTA_RHO_PATHWAY BIOCARTA_RHO_PATHWAY Arhgap1 Tln1 Cfl1 Ophn1 Pfn1 Rhoa Gsn Actr3 Arpc4 Arpc5 Pip5k1b Limk1 Mylk Arpc3 Arpc2 Arpc1b Baiap2 Actr2 Src Diaph1 Vcl Arhgef5 Rock1 Arhgap5 Arhgef11 PID_EPHRINB_REV_PATHWAY%MSIGDB_C2%PID_EPHRINB_REV_PATHWAY PID_EPHRINB_REV_PATHWAY Efnb2 Efnb1 Ephb1 Ephb2 Fga Ptpn13 Fgg Fgb Itga2b Rgs3 Lck Pik3r1 Map2k4 Fgr Dnm1 Nck2 Hck Map3k7 Fyn Rac1 Blk Tiam1 Yes1 Mapk8 Src Lyn Cxcr4 PID_UPA_UPAR_PATHWAY%MSIGDB_C2%PID_UPA_UPAR_PATHWAY PID_UPA_UPAR_PATHWAY Serpine1 Itgam Elane Itgb1 Itga3 Plau Fga Fgg Egfr Fgb Tgfb1 Lrp1 Ctsg Fpr1 Mmp9 Dock1 Rac1 Crk Src Bcar1 Mmp12 Itga5 Pdgfrb Mmp13 Gpld1 Vldlr Itgb2 Fn1 Klk4 Hgf Plg Vtn Fpr3 Fpr2 LOC100909609 Ctrc BIOCARTA_ACH_PATHWAY%MSIGDB_C2%BIOCARTA_ACH_PATHWAY BIOCARTA_ACH_PATHWAY Pik3r1 Pik3cg Ywhah Foxo3 Musk Rapsn Tert Src Chrnb1 Faslg Ptk2b Bad Akt1 Ptk2 BIOCARTA_VIP_PATHWAY%MSIGDB_C2%BIOCARTA_VIP_PATHWAY BIOCARTA_VIP_PATHWAY Prkar1b Ppp3cb Myc Prkacb Nfkbia Prkar2b Prkar2a Rela Nfatc2 Chuk Gnaq Vip Map3k1 Plcg1 LOC100912399 Egr2 Nfkb1 Egr3 Vipr2 Ppp3ca PID_S1P_META_PATHWAY%MSIGDB_C2%PID_S1P_META_PATHWAY PID_S1P_META_PATHWAY Gnai1 S1pr2 Sphk2 S1pr1 S1pr3 S1pr5 S1pr4 Gna14 Sphk1 Gna11 Gna15 Sgpl1 LOC688708 Gnai3 Gnao1 Gnai2 Gna12 Gnaz Gna13 Gnaq PID_ECADHERIN_STABILIZATION_PATHWAY%MSIGDB_C2%PID_ECADHERIN_STABILIZATION_PATHWAY PID_ECADHERIN_STABILIZATION_PATHWAY Rhoa Egfr Zyx Pvrl2 Nck1 Igf1r Stx4 Lima1 Exoc3 Git1 Mgat3 Igf1 Efna1 Ctnna1 Enah Myo6 Aqp3 Nckap1 Epha2 Kifc3 Actn1 Lpp Pip5k1c Cdh1 Ctnnd1 Abi1 Arf6 Diaph1 Vcl Rock1 Hgf Vasp PID_IL12_2PATHWAY%MSIGDB_C2%PID_IL12_2PATHWAY PID_IL12_2PATHWAY LOC497963 Tbx21 Cd8a Hlx Ccl4 Ripk2 Mapk14 B2m Gadd45g Il1r1 Cd8b Socs1 Nfkb2 Gzma Nfkb1 Gadd45b Ppp3cb Rela Il4 Mtor RT1-Db1 Stat6 Il1b Cd4 Il2rg Fos RT1-Da Atf2 Stat5a Stat1 Stat3 Ppp3ca Lck Sphk2 Il12rb2 Map2k6 Il2 Cd3g Faslg Ppp3r1 Il2ra Ccr5 Il12a Ifng Rab7a Cd247 Il12b Il18r1 Cd3d Il18 Cd3e PID_CXCR4_PATHWAY%MSIGDB_C2%PID_CXCR4_PATHWAY PID_CXCR4_PATHWAY Pik3cb Ptpn6 Itga3 Vps4b Rhoa Bad Prkcz Akt1 Gnai1 Rgs1 Mapkap1 Pik3r5 Itga4 Mmp9 Arr3 Itga11 Itga8 Itga7 Itga10 Itga6 Rhoc Pten Ralb Rac1 Grk6 Blk Csk Yes1 Ubqln1 Ptprc Adrbk1 Vps4a Itga5 Bcar1 Gna13 Cxcr4 Ssh1 Cxcl12 Mlst8 Mtor Stat2 Pxn RT1-Db1 Cd4 Rictor Foxo1 Itgb1 Pdpk1 Cfl1 RT1-Da Stat5b Stat5a Rhob Ptk2b Pak1 Vav1 Stat1 Inpp5d Stat3 Ptpn11 Lck Ptk2 Pik3r2 Pik3r1 Pik3r3 Fgr Dnm1 Limk1 Hck Pik3cg Plcb1 Fyn Pik3cd Plcb2 Crk Pik3r6 Gnai3 Arrb2 Cd3g Lyn Src Gnao1 Gnai2 Rap1b Plcb3 Gnaz Gnb1 Cd247 Cd3d Cd3e HALLMARK_HEME_METABOLISM%MSIGDB_C2%HALLMARK_HEME_METABOLISM HALLMARK_HEME_METABOLISM Clic2 Ucp2 Lpin2 Prdx2 March2 Rbm38 P4ha2 Ppox Smox Dcaf11 Bsg Dcun1d1 Dcaf10 Hdgf Epor Slc30a10 Tns1 Tnrc6b Asns Slc7a11 Top1 Ypel5 Mospd1 Slc4a1 Ell2 Slc2a1 Ctse Nfe2l1 Lamp2 Ctsb Fbxo9 Abcg2 Trim58 Fbxo7 Lmo2 Slc25a37 Slc25a38 Nfe2 Trim10 Xpo7 Glrx5 C3 Pdzk1ip1 Klf3 Atp6v0a1 Klf1 Car1 Ctns Nudt4 Ahsp Igsf3 Blvra Ezh1 Spta1 Blvrb Tcea1 Epb42 Abcb6 Alas2 Rbm5 Slc6a9 Htatip2 Bpgm Tyr Lrp10 Fbxo34 Ranbp10 Cdc27 Rhd Btrc Nek7 Narf Fn3k Adipor1 Sec14l1 Synj1 Tmcc2 Mark3 Rap1gap Tal1 Kel Cpox Slc30a1 Slc11a2 Car2 Khnyn Pigq Psmd9 Gypc Aqp3 Btg2 Tfdp2 Ncoa4 Snca Cat Fam46c Ccnd3 Gata1 Rcl1 Hagh Dmtn Arl2bp Add1 Agpat4 Riok3 Sdcbp Osbp2 RGD1564480 Add2 Mgst3 Hebp1 Vezf1 Mfhas1 Ank1 Hbb-b1 Hmbs Clcn3 Sptb Eif2ak1 Bach1 Rad23a Epb4.1 Cdr2 Htra2 Acsl6 Cir1 LOC100911167 Aldh6a1 Mocos Rnf19a Bcam Foxj2 Uros Pc Tfrc Pgls Trak2 Gapvd1 Fech Usp15 Urod Cast LOC100909468 Rhag Foxo3 Ppp2r5b Ftcd Picalm Nnt Alad Tmem9b Bnip3l Gclm Ubac1 Daam1 Optn Tspan5 Gmps Xk Gclc Slc10a3 PID_GLYPICAN_1PATHWAY%MSIGDB_C2%PID_GLYPICAN_1PATHWAY PID_GLYPICAN_1PATHWAY Nrg1 Vegfa Flt1 Tgfb1 LOC100911280 Lck App Lama1 Serpinc1 Fgfr1 Fgr Prnp Pla2g2a Hck Slit2 Fyn Blk Tdgf1 Yes1 Smad2 Tgfb3 Tgfb2 Src Lyn Fgf2 Tgfbr2 Tgfbr1 PID_FANCONI_PATHWAY%MSIGDB_C2%PID_FANCONI_PATHWAY PID_FANCONI_PATHWAY Fan1 Rpa1 Rad1 Rad50 Fancd2 Fancc Blm Brca1 Wdr48 Rad17 Stt3a RGD1306926 Fance Palb2 Rfc5 Rfc3 Rfc4 Rfc2 RGD1564719 Usp1 Rmi1 Rpa2 Ube2t Atrip Fancl Fancb Fanca Mre11a Fancf Hus1 Atr Brca2 Fbxw11 H2afx Hes1 Atm Nbn Sspo Topbp1 PID_FRA_PATHWAY%MSIGDB_C2%PID_FRA_PATHWAY PID_FRA_PATHWAY Il6 Plau Ccnd1 Sp1 Ccl12 Col1a2 Nfatc2 Nfatc3 Nos3 Txlng Thbd Bglap Mmp9 Mmp1 Gja1 Lif Dcn Atf4 Jun Itgb4 Dmtf1 Mgp Hmox1 Jund Junb Ccna2 Mmp2 Cdkn2a Fosl1 BIOCARTA_CTCF_PATHWAY%MSIGDB_C2%BIOCARTA_CTCF_PATHWAY BIOCARTA_CTCF_PATHWAY Mtor Pik3r1 Pik3cg Myc Pten Tp53 Ppp2ca Mdm2 Tgfb3 Rps6kb1 Cdkn1b Tgfb2 Smad5 Smad1 Cd79b Cdkn2a Tgfbr2 Cd79al Tgfbr1 Tgfbr3 Tgfb1 BIOCARTA_AKT_PATHWAY%MSIGDB_C2%BIOCARTA_AKT_PATHWAY BIOCARTA_AKT_PATHWAY Casp9 Pik3r1 Foxo1 Pik3cg Ppp2ca Ywhah Pdpk1 Nfkbia Foxo3 Ikbkb Faslg Rela Chuk LOC103692716 Nfkb1 Bad Ghr Foxo4 Akt1 BIOCARTA_SARS_PATHWAY%MSIGDB_C2%BIOCARTA_SARS_PATHWAY BIOCARTA_SARS_PATHWAY Anpep Ldhb Ldhc Fbl Gpt Mapk14 Ckm BIOCARTA_CTL_PATHWAY%MSIGDB_C2%BIOCARTA_CTL_PATHWAY BIOCARTA_CTL_PATHWAY Cd3g Faslg B2m Itgb2 Icam1 Cd247 Itgal Fas Cd3d Cd3e PID_TNF_PATHWAY%MSIGDB_C2%PID_TNF_PATHWAY PID_TNF_PATHWAY Smpd1 Tradd Ripk1 Fadd Adam17 Birc3 Casp8 Bag4 Tnfrsf1b Map3k1 LOC100912399 Nfkb1 Stat1 Birc2 Prkcz Nsmaf Map3k7 Map2k7 Prkci Tnfrsf1a Tab2 Ikbkb Traf2 Tnik Nrk Map4k2 Rela Map3k3 Chuk Rffl Smpd2 Sqstm1 Madd Map4k3 Map4k5 Txn1 Cyld BIOCARTA_BAD_PATHWAY%MSIGDB_C2%BIOCARTA_BAD_PATHWAY BIOCARTA_BAD_PATHWAY Kitlg Pik3r1 Igf1r Il3ra Bax Prkar1b Bcl2 Igf1 Pik3cg Ywhah Prkacb Mapk1 Csf2rb Prkar2b Prkar2a Rps6ka1 Bad Bcl2l1 Kit Akt1 PID_BETA_CATENIN_NUC_PATHWAY%MSIGDB_C2%PID_BETA_CATENIN_NUC_PATHWAY PID_BETA_CATENIN_NUC_PATHWAY Tcf4 Hbp1 Camk4 Smarca4 Igf2bp1 T Neurog1 Hdac1l Hdac2 Apc Lef1 Ywhae Hdac1 Ar Mmp9 Ywhab Incenp Ncoa2 Ywhah Pitx2 Ywhag Axin2 Ywhaz Mmp2 Tnik Cdkn2a Sspo Krt1 Myc Ccnd1 Tert Sfn Ctbp1 Xpo1 Cacna1g Tcf7l1 Ruvbl2 Skp1 Zcchc12 Tle4 Cul1 Tle1 Tle2 Adcy7 Jun Kcnip4 Cyr61 Mitf Vcan Chd8 Fgf4 Med12 Klf4 Cdh1 Aes Tbl1xr1 Cdx4 Dkk4 Cby1 Mt-co2 Dkk1 Dvl3 Id2 Myog Myf5 Sp5 Tbl1x Ctnnbip1 Tcf7 PID_KIT_PATHWAY%MSIGDB_C2%PID_KIT_PATHWAY PID_KIT_PATHWAY Kitlg Hras Ptpn6 Bcl2 Tec LOC100911248 Epo Crkl Gab1 Pdpk1 Map2k1 Sos1 Map2k2 Epor Socs1 Ptpro Fer Shc1 Stap1 Map4k1 Gsk3b Matk Pik3c2b Stat5a Spred1 Spred2 Stat1 Vav1 Bad Stat3 Ptpn11 Akt1 Pik3r1 Pten Raf1 Mitf Grb2 Cbl Foxo3 Rps6kb1 Mapk8 Lyn Crebbp Grb10 Dok1 Sh2b2 Kit BIOCARTA_CYTOKINE_PATHWAY%MSIGDB_C2%BIOCARTA_CYTOKINE_PATHWAY BIOCARTA_CYTOKINE_PATHWAY Il4 Il5 Il16 Il6 Il10 Il17a Ifnb1 Il15 Il13 Lta Il9 Il2 Il12a Ifng Il12b Il1a Il18 BIOCARTA_CREB_PATHWAY%MSIGDB_C2%BIOCARTA_CREB_PATHWAY BIOCARTA_CREB_PATHWAY Pik3r1 Hras Prkar1b Prkcb Mapk14 Camk2d Camk2g Prkacb Rac1 Grb2 Mapk1 Sos1 Camk2a Creb1 Prkar2b Prkar2a Prkca Rps6ka1 Akt1 Rps6ka5 BIOCARTA_MAPK_PATHWAY%MSIGDB_C2%BIOCARTA_MAPK_PATHWAY BIOCARTA_MAPK_PATHWAY Tradd Ripk1 Cebpa Mapk14 Sp1 Creb1 Mapk6 Mapk4 Mapkapk2 Nfkb1 Mapkapk3 Mapk10 Rps6ka3 Tgfb1 Map3k9 Map3k4 Map3k6 Map3k12 Rps6ka2 Map3k13 Map3k10 Max Raf1 Mknk2 Map3k7 Mknk1 Rac1 Nfkbia Map3k2 Mapk1 Araf Rapgef2 Map2k5 Tgfb3 Map3k8 Rps6kb1 Mapk8 Ikbkb Tgfb2 Traf2 Map4k2 Map3k3 Rela Chuk Tgfbr1 Rps6ka1 Map3k14 Map4k3 Map4k5 Rps6ka5 Mapk12 Mapk13 Mapk11 Hras Myc Fos Mapkapk5 Map2k1 Map2k2 Mef2c Shc1 Atf2 Map4k1 Map3k1 LOC100912399 Pak1 Stat1 Elk1 Daxx Pak2 Map2k4 Mapk9 Mef2d Jun Map3k11 Map2k7 Grb2 Map2k6 BIOCARTA_ACE2_PATHWAY%MSIGDB_C2%BIOCARTA_ACE2_PATHWAY BIOCARTA_ACE2_PATHWAY Agt Col4a5 LOC100911572 Agtr2 Ace3 Cma1 Ace Col4a2 Col4a3 Ren Agtr1a Col4a1 BIOCARTA_PPARA_PATHWAY%MSIGDB_C2%BIOCARTA_PPARA_PATHWAY BIOCARTA_PPARA_PATHWAY LOC497963 Hspa1a Hspa1b Rxra Me1 Apoa2 Ppara Nr2f1 mrpl11 Myc Sp1 Prkacb Nr1h3 Pdgfa Cpt1b Fabp1 Dusp1 Stat5b Med1 Prkar2b Prkar2a Stat5a Nr0b2 LOC103692716 Cited2 Fat1 Rb1 Pik3r1 Ppargc1a Ins2 Prkar1b Ehhadh Nrip1 Prkcb Pik3cg Ptgs2 Ncoa1 Jun Nfkbia Sra1 Mapk1 Lpl Crebbp Ncor2 Hsd17b4 Acox1 Rela Prkca BIOCARTA_EGFR_SMRTE_PATHWAY%MSIGDB_C2%BIOCARTA_EGFR_SMRTE_PATHWAY BIOCARTA_EGFR_SMRTE_PATHWAY Rxra Ncor2 Mapk14 Thrb Map3k1 LOC100912399 Egfr Map2k1 Zbtb16 Rara Thra HALLMARK_XENOBIOTIC_METABOLISM%MSIGDB_C2%HALLMARK_XENOBIOTIC_METABOLISM HALLMARK_XENOBIOTIC_METABOLISM Cyp2e1 Cyp1a2 Lcat Lpin2 Acp1 Hacl1 Tmem97 Cndp2 Leap2 Hsd11b1 Cyp1a1 Smox Kynu Pdk4 Aox1 Pdlim5 Il1r1 Dhps Acp2 Ddah2 Fabp1 Adh6 Slc12a4 Nfs1 Adh7 LOC100911854 Cyb5a Atoh8 Gstm4 Slc35d1 Cyp17a1 Psmb10 Cyp26a1 Arg1 Rbp4 Cbr1 Ptgr1 Mbl2 Slc1a5 Mt2A Tpst1 Ccl25 LOC100909857 Cyp27a1 Csad G6pc Fah Por Itih4 Arpp19 Ndrg2 Blvrb Nmt1 Gstt2 Upp1 Sertad1 Itih1 Maoa Pros1 Slc46a3 Ninj1 Tyr Plg Fbp1 Hes6 Ahcy Sar1b Esr1 Idh1 Rap1gap Car2 Elovl5 Jup Epha2 Hmox1 Serpine1 Ech1 C2 Retsat Aldh9a1 Igf1 Cat Serpina6 Ces1d Tgfb2 Pts LOC100911034 Bcar1 Ap4b1 Xdh Gart Acox1 Apoe Fetub Cyp2s1 Angptl3 Vtn Tmem176b Mthfd1 Gch1 F11 F10 Abcd2 Reg1a Casp6 Atp2a2 Etfdh Kars Ttpa Fbln1 Lonp1 Crot Dhrs1 Tdo2 RGD1564480 Mccc2 Ets2 Abhd6 Dhrs7 Fas Gnmt Pink1 Papss2 Shmt2 Aldh3a1 Nqo1 Gsr Pmm1 Upb1 Gss Irf8 Aco2 Ptges Vnn1 Crp Slc6a6 Entpd5 Ephx1 Ugdh Akr1c2 Akr1c3 Bphl Ptgds Gad1 Hgfac Comt Pc Cyp4f4 Tat Hsd17b2 Gabarapl1 Bcat1 Acox3 Ppard Gsto1 Tnfrsf1a Asl Ddt Cdo1 Pycr1 March6 Man1a1 Cda Slc6a12 Gcnt2 Acox2 Ddc Hnf4a Id2 Tkfc Igfbp4 Igfbp1 Aldh2 Fmo1 Gclc Slc22a1 Fmo3 HALLMARK_BILE_ACID_METABOLISM%MSIGDB_C2%HALLMARK_BILE_ACID_METABOLISM HALLMARK_BILE_ACID_METABOLISM Rxra Hacl1 Abca2 Klf1 Cyp27a1 Abca3 Slc27a2 Gnpat Lonp2 Idh1 Idh2 Mlycd Nr0b2 Rxrg Lck Hao1 Slc22a18 LOC100362350 Cyp46a1 Pex1 Lipe Abca5 Slc29a1 Aldh8a1 Abca4 Abca1 Akr1d1 Slc27a5 Sult1b1 Amacr Paox Pex26 Bcar3 Tfcp2l1 Bbox1 Prdx5 Agxt Soat2 Pnpla8 Pxmp2 Ephx2 Pex16 Ch25h Pex6 Pex12 Cyp8b1 Slc35b2 Pex7 Fads1 Cyp7a1 Slc23a2 Gc Fdxr Hsd17b6 Nudt12 Retsat Slco1a4 Sod1 Cyp7b1 Nr1h4 Phyh Abcg8 Rbp1 Dio1 Efhc1 Isoc1 Pex11g Aldh1a1 Pipox Idi1 Bmp6 Ar Nr1i2 Atxn1 Abcg4 Hsd17b11 Aldh9a1 Abcd1 Scp2 Cat Ttr Serpina6 Hsd17b4 Dhcr24 Pex11a Abcd2 Abcd3 Crot Gnmt Sult2b1 Gstk1 Acsl1 Acsl5 Hsd3b7 Pex13 Cyp39a1 Gclm Optn BIOCARTA_FEEDER_PATHWAY%MSIGDB_C2%BIOCARTA_FEEDER_PATHWAY BIOCARTA_FEEDER_PATHWAY Lct Pgm1 Pygm Pygl Mpi Khk ST_MYOCYTE_AD_PATHWAY%MSIGDB_C2%ST_MYOCYTE_AD_PATHWAY ST_MYOCYTE_AD_PATHWAY Gnai1 Kcnj3 Gast Rho Adrb1 Asah1 Kcnj9 Cav3 Camp Dag1 Ptx3 Pitx2 Kcnj5 Rac1 Mapk1 Dlg4 C2 Itpr1 Apc Itpr3 Kat5 Gnaq Ephb2 Akt1 BIOCARTA_P35ALZHEIMERS_PATHWAY%MSIGDB_C2%BIOCARTA_P35ALZHEIMERS_PATHWAY BIOCARTA_P35ALZHEIMERS_PATHWAY App Csnk1d Cdk5 Gsk3b LOC100911363 LOC100912380 Csnk1a1 Capns1 Ppp2ca Cdk5r1 Capn1 BIOCARTA_TEL_PATHWAY%MSIGDB_C2%BIOCARTA_TEL_PATHWAY BIOCARTA_TEL_PATHWAY Igf1r Rb1 Bcl2 Xrcc6 Myc Tp53 Xrcc5 Ppp2ca Tert Prkca Kras LOC103692716 Egfr Terf1 Polr2a Akt1 Tnks HALLMARK_IL6_JAK_STAT3_SIGNALING%MSIGDB_C2%HALLMARK_IL6_JAK_STAT3_SIGNALING HALLMARK_IL6_JAK_STAT3_SIGNALING Il1r1 Socs1 Socs3 Tnfrsf12a Tgfb1 Tlr2 Pik3r5 Il17rb Itga4 Cd14 Il3ra Csf3r Bak1 Inhbe Cxcl9 Pla2g2a Tnfrsf21 Cxcl3 Ltbr Pf4 Cxcl2 Ifngr2 Ifngr1 Acvr1b Irf1 Map3k8 Il10rb Il9r Osmr Il1r2 Il6st Cd44 Dntt Cxcl10 Cxcl11 Ebi3 Cxcl13 LOC100360218 Csf1 Il17ra Myd88 Reg1a Stat2 Il6 Il4r Irf9 Il1b Il2rg Ifnar1 Fas Csf2 Tnfrsf1b Pim1 Csf2rb Leprot Stat1 Stat3 Ptpn11 Il13ra1 Pdgfc Lepr Ptpn1 Stam2 Jun A2m Ccr1 Ccl7 Grb2 Il7 Tnfrsf1a Ptpn2 Hmox1 Cbl Cd38 Acvrl1 Cntfr Il2ra Il18r1 PID_LIS1_PATHWAY%MSIGDB_C2%PID_LIS1_PATHWAY PID_LIS1_PATHWAY Csnk2a1 Iqgap1 Ndel1 LOC100909750 Pafah1b1 Katna1 Rac1 Cdk5r1 Dab1 Cdk5 Abl1 Reln Lrp8 Ywhae Vldlr Dynlt1 Lrpap1 Cdk5r2 Rhoa Pafah1b3 Dcx Dync1h1 Pla2g7 Map1b BIOCARTA_CASPASE_PATHWAY%MSIGDB_C2%BIOCARTA_CASPASE_PATHWAY BIOCARTA_CASPASE_PATHWAY Casp6 Casp9 Casp3 Casp1 Lmnb1 Parp1 Casp4 Birc3 Casp2 Arhgdib Lmna Lmnb2 Casp8 Dffb Cycs Xiap Apaf1 Birc2 Dffa PID_MAPK_TRK_PATHWAY%MSIGDB_C2%PID_MAPK_TRK_PATHWAY PID_MAPK_TRK_PATHWAY Hras Mapk14 Fos Map2k1 Ntf3 Srf Mef2c Creb1 Cdk5 Kras Mapkapk2 Elk1 Rit2 Rit1 Ehd4 Prkcd Egr1 Trpv1 Raf1 Map3k2 Cdk5r1 Mapk1 Map2k5 Nras Map2k6 Rap1b Rap1a Rps6ka1 Rps6ka5 PID_RHOA_PATHWAY%MSIGDB_C2%PID_RHOA_PATHWAY PID_RHOA_PATHWAY Ppp1r12a Mapk12 Scai Itgb1 Pkn2 Fos Slc9a3 Slc9a1 Rdx Cit Cfl1 Rock2 Ezr Tln1 Mkl1 Limk2 Srf Cdkn1b Atf2 Pld2 Pld1 F2rl2 Rhoa Prkcz Map2k4 Pip5k1b Limk1 Pard6a Acta1 Jun Pten Cyr61 Pip5k1c Map2k6 Mapk8 Msn Sh3gl2 Diaph1 Vcl Rock1 Pkn1 BIOCARTA_CELLCYCLE_PATHWAY%MSIGDB_C2%BIOCARTA_CELLCYCLE_PATHWAY BIOCARTA_CELLCYCLE_PATHWAY Cdk2 Rb1 Ccnh Cdkn2b Rbl1 Ccnd1 E2f1 Cdkn2c Cdkn1a Cdk4 Cdkn1b Cdkn2a Cdk1 Cdc25a Ccne1 Ccnd3 Cdk7 Cdk6 Ccna1 BIOCARTA_LYM_PATHWAY%MSIGDB_C2%BIOCARTA_LYM_PATHWAY BIOCARTA_LYM_PATHWAY Itga4 Cd34 Vcam1 Itgb1 Itgb2 Icam1 Il1a LOC100911324 Itgal PID_IL6_7_PATHWAY%MSIGDB_C2%PID_IL6_7_PATHWAY PID_IL6_7_PATHWAY Mapk11 Pias1 Il6 Jak1 Mapk14 Foxo1 Myc Fos Gab1 Gab2 Sos1 Socs3 Crp Timp1 Lbp Stat1 Ptpre Vav1 Fgg Hsp90b1 Stat3 Ptpn11 Akt1 Pik3r1 Map2k4 Prkcd Hck Jun A2m Rac1 Mitf Grb2 Irf1 Junb Map2k6 Lmo4 Il6st Pias3 Bcl2l1 BIOCARTA_TRKA_PATHWAY%MSIGDB_C2%BIOCARTA_TRKA_PATHWAY BIOCARTA_TRKA_PATHWAY Ntrk1 Ngf Pik3r1 Shc1 Hras Prkcb Prkca Plcg1 Grb2 Sos1 Akt1 BIOCARTA_AHSP_PATHWAY%MSIGDB_C2%BIOCARTA_AHSP_PATHWAY BIOCARTA_AHSP_PATHWAY Hbb-b1 Gata1 Hba2 Uros Hmbs Alad Alas2 Cpox Fech Urod Ahsp LOC100911167 BIOCARTA_TNFR1_PATHWAY%MSIGDB_C2%BIOCARTA_TNFR1_PATHWAY BIOCARTA_TNFR1_PATHWAY Tradd Ripk1 Casp3 Fadd Parp1 Casp8 Bag4 Dffb Map3k1 LOC100912399 Pak1 Dffa Rb1 Pak2 Map2k4 Lmnb1 Jun Sptan1 Casp2 Map3k7 Cradd Arhgdib Lmna Prkdc Tnfrsf1a Lmnb2 Mapk8 Traf2 Madd BIOCARTA_SHH_PATHWAY%MSIGDB_C2%BIOCARTA_SHH_PATHWAY BIOCARTA_SHH_PATHWAY Dyrk1a Gli1 Gli2 Ptch1 Shh Prkar1b Prkacb Smo Dyrk1b Sufu Gsk3b Prkar2b Prkar2a BIOCARTA_VDR_PATHWAY%MSIGDB_C2%BIOCARTA_VDR_PATHWAY BIOCARTA_VDR_PATHWAY Med1 Rxra Crebbp Ncoa1 Ncoa2 Carm1 Tsc2 Hdac1 Hdac1l BIOCARTA_EPHA4_PATHWAY%MSIGDB_C2%BIOCARTA_EPHA4_PATHWAY BIOCARTA_EPHA4_PATHWAY Lyn L1cam Rap1b Epha4 Acta1 Ephb1 Itgb1 Fyn Selp PID_BMP_PATHWAY%MSIGDB_C2%PID_BMP_PATHWAY PID_BMP_PATHWAY Fst Ctdspl Rgma Bmpr2 Bmp7 Hfe2 Chrdl1 Chrd Grem1 Smad6 Smad5 Smad1 Bmp4 Gsk3b Bmp2 Sostdc1 Nog Bmp6 Ctdsp1 Map3k7 Bambi Zfyve16 Mapk1 Tab2 Smad7 Ppp1ca Ppp1r15a Xiap Smurf1 BIOCARTA_RB_PATHWAY%MSIGDB_C2%BIOCARTA_RB_PATHWAY BIOCARTA_RB_PATHWAY Cdk2 Rb1 Mapk14 Tp53 Ywhah Stt3a Wee1 Cdk4 Atm Myt1 Cdk1 Cdc25b Cdc25c BIOCARTA_41BB_PATHWAY%MSIGDB_C2%BIOCARTA_41BB_PATHWAY BIOCARTA_41BB_PATHWAY Il4 Mapk14 Jun Nfkbia Il2 Mapk8 Ikbkb Tnfrsf9 Atf2 Traf2 Rela Chuk Map3k1 Ifng LOC100912399 Nfkb1 Map4k5 BIOCARTA_BCELLSURVIVAL_PATHWAY%MSIGDB_C2%BIOCARTA_BCELLSURVIVAL_PATHWAY BIOCARTA_BCELLSURVIVAL_PATHWAY Mtor Pik3r1 Casp3 Xiap Pik3cg Itgb1 Fos Dpf2 Cct4 Zbtb7a Jund Akt1 HALLMARK_REACTIVE_OXIGEN_SPECIES_PATHWAY%MSIGDB_C2%HALLMARK_REACTIVE_OXIGEN_SPECIES_PATHWAY HALLMARK_REACTIVE_OXIGEN_SPECIES_PATHWAY Txnrd1 Prdx1 Gpx3 Prdx4 Stk25 Prdx2 Prdx6 Hmox2 Egln2 Pdlim1 Sbno2 Srxn1 Vimp Lamtor5 Glrx2 Atox1 Ndufa6 Oxsr1 Nqo1 Gsr Sod2 Sod1 Prnp Cat Mpo Junb LOC688708 Glrx Gclm Fes Msra Pfkp Ppp2r4 Lsp1 Ndufs2 Hhex Gpx4 Txn1 Gclc Mgst1 Txnrd2 BIOCARTA_CERAMIDE_PATHWAY%MSIGDB_C2%BIOCARTA_CERAMIDE_PATHWAY BIOCARTA_CERAMIDE_PATHWAY Smpd1 Nsmaf Tradd Ripk1 Fadd Bax Map2k4 Bcl2 Raf1 Map2k1 Mapk1 Tnfrsf1a Casp8 Aifm1 Mapk8 Cycs Traf2 Rela Map3k1 LOC100912399 Nfkb1 Bad HALLMARK_HYPOXIA%MSIGDB_C2%HALLMARK_HYPOXIA HALLMARK_HYPOXIA Aldoc Igfbp3 Atf3 P4ha2 Irs2 Pnrc1 Cdkn1b Vegfa Col5a1 Slc2a1 Cited2 Pdk3 Rragd Mt2A Ppargc1a Nfil3 Tgfb3 Ppp1r15a Ctgf Prkca Fbp1 Gpi Slc25a1 Ampd3 Ldhc Klf7 Akap12 S100a4 Ak4 Gys1 LOC100911597 Angptl4 Cp Pgk1 Klf6 LOC102550316 Chst3 Grhpr Dusp1 Ugp2 Hexa Tes Ncan Siah2 Tmem45a Dcn Efna1 Hmox1 Aldob Nagk Prdx5 Ddit3 Serpine1 Dpysl4 Bhlhe40 Pam Pdgfb Aldoa Ero1l Vhl Sdc4 Brs3 Sdc3 Pklr Cdkn1a Sdc2 Stbd1 Mif Ilvbl Kdm3a Xpnpep1 Ppfia4 Slc2a5 Car12 Zfp292 Gapdhs Adm Hs3st1 Hoxb9 Pdk1 Eno1 Tmem45al Eno2 Kdelr3 Eno3 Wisp2 Large Stc1 Myh9 Pck1 Galk1 Plin2 P4ha1 Stc2 Slc37a4 Slc2a3 Tktl1 Hspa5 Ankzf1 LOC100911625 Maff F3 Pgm1 Ndst2 Pygm Ccrn4l Atp7a Ackr3 Srpx Pgam2 Cxcr4 Ndst1 Vldlr Fam162a Tpd52 Phkg1 B3galt6 Isg20 Plac8 Gpc4 Klhl24 Casp6 Ddit4 Pkp1 Il6 Ets1 Bcl2 Fos Edn2 Sult2b1 Pim1 Hk2 Adora2b Map3k1 LOC100912399 Slc6a6 Egfr Ext1 Ccng2 Csrp2 Pgf Prkcdbp Anxa2 Tiparp Tgm2 Gaa Tpst2 Jun Lalba Cyr61 Mt1 Hdlbp Btg1 Ppp1r3c Tpbg Foxo3 Pfkfb3 Bcan Kif5a Rora Ier3 Scarb1 Glrx Gcnt2 Lox Bnip3l Pgm2 Inha Pfkp Pfkl Lxn Ndrg1 Igfbp1 Ptrf LOC100910284 Jmjd6 Has1 PID_TXA2PATHWAY%MSIGDB_C2%PID_TXA2PATHWAY PID_TXA2PATHWAY Mapk14 Gnaq Rhoa Prkcz Nos3 Akt1 Pik3r5 Arr3 Prkcd Blk Rac1 Yes1 Adrbk1 Gna12 Gna13 Rock1 Prkca Icam1 Ptgir Mapk11 Ptgdr Vcam1 Prkaca Gnb5 Syk Gna11 Tbxa2r Slc9a3r1 Prkch Egfr Ptgdrl Prkcq Sele Lck Fgr Prkcb Dnm1 Hck Tgm2 Pik3cg Fyn Plcb2 Gna14 Gna15 Pik3r6 Arrb2 Src Lyn Gnai2 Rab11a Gnb1 NABA_SECRETED_FACTORS%MSIGDB_C2%NABA_SECRETED_FACTORS NABA_SECRETED_FACTORS Ccl5 Lefty1 Ccl3 Ccl2 Wnt10a Csf3 Wnt10b Dhh Ccl1 Mst1 Epo Il23a Hcfc2 Il36rn Egfl6 Pdgfa Crlf1 Egfl8 Thpo Hbegf Nrg1 Il1f10 Vegfa Wnt2b Bmp15 Sfrp5 Sfrp4 Sfrp2 Sfrp1 Gdf11 Gdf10 Cntf Gdf15 Btc Wnt3a Tgfb1 Tgfa Hhip Il17d Il17c Il17b Ptn Ccl24 Inhbe Ccl22 Cxcl9 Ccl28 Il17f Cxcl3 Lefty2 Ccl21 Ccl20 Pf4 Cxcl2 Tnfsf4 Igf2 Fstl3 Fstl1 Tgfb3 Frzb Angpt1 Ccl19 Ppbp Wnt6 Angpt4 Ihh Ccl17 Wnt11 Fgf2 Wnt4 Wnt3 Cxcl10 Inhbb Cxcl11 Ccbe1 Ebi3 S100a16 Il1a Cxcl13 S100a10 S100a13 Pspn Csf1 Angpt2 Inhba Inhbc Ngf LOC100912356 S100a3 S100a1 Cxcl1 Cx3cl1 Mstn Cxcl6 Lep Xcl1 Scube3 Crnn Scube1 S100a9 S100a8 Wif1 S100a6 S100a5 Il2 LOC100911486 Faslg Wnt5b Clcf1 Chrdl2 Wnt5a Fst Bmp7 Wnt16 Chrdl1 Chrd Ntf3 Bmp4 Bmp2 Ins2 Shh Igf1 Tdgf1 Tnfsf13b Tgfb2 Tnfsf13 Hgf Angptl3 Il4 Il5 Kitlg Il6 Il1b Csf2 Ccl11 Ccl12 Osm Gdnf Hgfac Fgf16 Ccl4 Fgf22 Prl Ccl25 S100a4 Angptl4 Lif Cbln1 Il36b Megf6 Wfikkn1 Tnfsf10 Cbln3 Il36a Ntf4 Pdgfb Cbln2 Fgf5 Fgf6 Fgf7 Fgf8 Wfikkn2 Bmp3 Fgf1 Fgf3 Il36g Fgfbp1 Wnt1 Vegfc Fgfbp3 Il34 Fgf9 Ctf1 Cxcl14 Il22 Il20 Il25 Il24 Bmp6 Cxcl12 Prmt2 Fgf20 Il16 Fgf21 Mdk Il10 Fgf23 Ifnb1 Il17a Pik3ip1 Il15 Insl3 Il13 Angptl1 Angptl2 Lta Il9 Angptl6 Vwc2l Insl6 Fgf12 Fgf13 Fgf10 Wnt7a Wnt7b Fgf11 Fgf14 Fgf17 Bdnf Nodal Tnfsf12 Fgf19 Tnfsf14 Tnfsf15 Wnt8b Wnt8a Gdf3 Tpo Gdf7 Gdf2 Megf9 Pdgfc S100b Gdf6 Pgf S100z S100g Wnt9a Ereg Gdf9 Nrg3 Rptn Wnt9b Ccl7 Nrg4 Il7 Eda Megf10 Fgf4 Figf Bmp8a Nrg2 Zfp91 Ifnk Megf11 Crhbp Il1rn Artn Nrtn Areg Il12a Inha Amh Ifng Il11 Brinp3 Il12b Cbln4 Brinp2 Il18 Il19 Vwc2 SA_TRKA_RECEPTOR%MSIGDB_C2%SA_TRKA_RECEPTOR SA_TRKA_RECEPTOR Hras Pik3cd Map2k1 Grb2 Map2k2 Sos1 Cdkn1a Ntrk1 Ngf Shc1 Ngfr Rhoa Akt2 Akt3 Elk1 Akt1 BIOCARTA_WNT_PATHWAY%MSIGDB_C2%BIOCARTA_WNT_PATHWAY BIOCARTA_WNT_PATHWAY Nlk Csnk2a1 Csnk1a1 Tle1 Btrc Myc Ccnd1 Map3k7 Ppp2ca Ppard Wif1 Hdac1l Csnk1d Wnt1 Apc Fzd1 Crebbp Lef1 Gsk3b Dvl1 Ctbp1 Hdac1 HALLMARK_FATTY_ACID_METABOLISM%MSIGDB_C2%HALLMARK_FATTY_ACID_METABOLISM HALLMARK_FATTY_ACID_METABOLISM Acadl Cryz Echs1 Me1 Hmgcs2 Gad2 Bckdhb Ppara Nsdhl Ptprg Metap1 Cyp1a1 Aqp7 Eci1 Hsph1 Gcdh Apex1 Nthl1 Aldh3a2 Idh3B Fabp1 Adh6 Erp29 Lgals1 Cd1d1 Serinc1 Adh7 Reep6 Ccdc58 Pdhb Cpt2 Hibch Slc22a5 LOC103692716 Inmt Fabp2 Acadm Acads Fh Cbr1 Dld Aadat Acaa2 Decr1 Pcbd1 Cyp4a8 Car6 Car4 Cyp4a1 Psme1 Suclg1 Suclg2 Ywhah Hsd17b10 Hmgcs1 Acat2 Gpd1 Mcee Gpd2 Auh Blvra Hsd17b7 Hadhb Acot2 Acadvl Mgll Sdhd Sdha Mdh1 Maoa RGD1562948 Sdhc Aoc3 LOC100909949 Mdh2 S100a10 Cbr3 Dlst Ltc4s Acss1 Grhpr Idh1 Mlycd Cpox Elovl5 Car2 Cpt1a Sucla2 Hsdl2 H2afz Rdh16 Ube2l6 Rap1gds1 Hpgd Ncaph2 Nbn Tp53inp2 D2hgdh Ostc LOC100365958 Acsm3 G0s2 Hadh Odc1 Adipor2 Idh3g Adsl Hccs Eci3 Hao2 Aldoa Ech1 Mif Rdh11 Retsat Gapdhs Setd8 Eno2 Aldh1a1 Idi1 Eno3 Ehhadh Hsd17b11 Aldh9a1 Crat LOC100911625 Pts Hsd17b4 Acox1 Cel Hmgcl Dhcr24 Etfdh Prdx6 Tdo2 Aldh3a1 Acsl1 Acsl5 Acot8 Aco2 Acsl4 Vnn1 Ephx1 Ugdh Bphl Uros Gabarapl1 Urod Alad Fmo1 HALLMARK_ALLOGRAFT_REJECTION%MSIGDB_C2%HALLMARK_ALLOGRAFT_REJECTION HALLMARK_ALLOGRAFT_REJECTION Ccl5 LOC497963 Cd8a Ccl2 Ccl4 Ptpn6 Ripk2 B2m Cd8b Socs1 Cd1d1 LOC100911854 Gzma Psmb10 Tgfb1 Tlr2 Mbl2 Ccl22 Cxcl9 Zap70 Map3k7 Pf4 Ifngr2 Csk Ifngr1 Ptprc Ccl19 Ikbkb Apbb1 Inhbb Itgb2 F2 Icam1 Cxcl13 Itgal Csf1 Inhba Cd40 Il4r Il2rg Ube2d1 Cd79al Timp1 Lck Npm1 Fgr Prkcb Lif Hif1a Thy1 Mtif2 Rps3a Nme1 Ncf4 Sit1 Il2 Socs5 Cd47 Lyn Faslg RT1-Ba Abi1 RT1-S3 Dyrk3 Ccr5 Il2ra Cxcr3 LOC103689992 Itk Tapbp Il27ra Rpl3l LOC100909630 Cfp RT1-M3-1 LOC100909593 Flna Rpl39 Tap1 Tap2 RT1-DOb F2r Brca1 Cd28 RT1-DOa Cd2 Fyb Cd7 Crtam Elf4 Hcls1 Cartpt Abce1 C2 Cd40lg Eif5a Igsf6 Tlr3 Tlr6 Galnt1 Gpr65 Trat1 Gcnt1 Ube2n RT1-DMa RT1-DMb Cd96 Wars Rps19 Ncr1 Akt1 Gbp2 Glmn Eif3a Eif3j Mmp9 Rars Ly86 Irf7 Capg Eif3d Icoslg Mrpl3 Srgn Cd74 Dars Fcgr2b Nlrp3 Lcp2 Tgfb2 Traf2 Cdkn2a Acvr2a Ccnd3 Krt1 Tpd52 Cd86 Degs1 Eif4g3 Aars Ly75 Il4 Il16 Il6 Ets1 Il10 Il1b Cd4 Il15 Elane Il13 Il9 Fas Ccl11 Ccl12 RT1-Da Map4k1 Irf8 Stat1 Egfr Bcl10 Spi1 Nck1 Ereg Cd80 Bcat1 Ccr1 Ccl7 Il7 Cd3g Il12a Ifng Cd247 Il11 Il12b Cd3d Il18 Cd3e BIOCARTA_BARRESTIN_SRC_PATHWAY%MSIGDB_C2%BIOCARTA_BARRESTIN_SRC_PATHWAY BIOCARTA_BARRESTIN_SRC_PATHWAY Gngt1 Hras Src Dnm1 Arrb1 Hck Plcb1 Raf1 Gnb1 Mapk1 Map2k1 Map2k2 HALLMARK_MYOGENESIS%MSIGDB_C2%HALLMARK_MYOGENESIS HALLMARK_MYOGENESIS Igfbp3 Clu Tnni1 Hbegf Scd1 Chrna1 Gadd45b Bdkrb2 Tgfb1 Itga7 Myf6 Fgf2 Tsc2 Mapk12 Notch1 LOC100911597 Sphk1 Chrnb1 Des Foxo4 Rit1 Acta1 Itgb4 Kifc3 Cacng1 Gnao1 Svil Agl Fst Bhlhe40 Nos1 Col4a2 Cdkn1a Ppfia4 Ctf1 LOC100360417 Akt2 Gsn Eno3 Cox6a2 App Tnnc1 Large Tnnc2 Rb1 Cryab Myh9 Pick1 Ephb3 Prnp Cnn3 Cav3 Igf1 Myo1c Crat Mylk Sirt2 Stc2 Actc1 Spdef Sptan1 Smtn Ptgis Ptp4a3 Ncam1 Nav2 Cfd Aplnr Bag1 Pygm Plxnb2 Fdps Eif4a2 Myl7 Erbb3 Gja5 Csrp3 Pgam2 Cdh13 Speg LOC102551071 Tagln Sparc Fxyd1 Kcnh2 Mylpf Igfbp7 Dmpk Gpx3 Cacna1h Ankrd2 Myh3 Schip1 Myh1 Lpin1 Sspn Tnnt2 Itgb1 Tnnt1 Sgcg Tnnt3 Gabarapl2 Bin1 Sorbs3 Col1a1 Hrc Mef2c Nqo1 Myl3 Sgcd Acsl1 Tpm2 Fabp3 Sgca Kcnh1 Col3a1 Myom1 Pdlim7 Pvalb Myom2 Myh7 Reep1 Ckm Sh3bgr Myl1 Col6a2 Fhl1 Myh11 Apod Tpd52l1 Pc Psen2 Agrn Mef2d Tnni2 Gaa Klf5 Efs Mras Atp6ap1 St5 Flii Ppp1r3c Adam12 Myoz1 Pkia Casq1 Actn2 Actn3 Ldb3 Casq2 Sod3 Mapre3 Hspb8 Mybpc3 Lsp1 Myog Ckb Wwtr1 Aebp1 Mb Mybph Hspb2 Sorbs1 NABA_CORE_MATRISOME%MSIGDB_C2%NABA_CORE_MATRISOME NABA_CORE_MATRISOME Igfbp3 Fndc7 Wisp3 Egflam Fndc8 Vwa5b1 Tecta Wisp1 Vwa5b2 Cthrc1 Sbspon Slit3 Slit1 Col6a6 Emid1 Col6a1 Dpt Omd Papln Col11a2 Chad Prg2 Col5a1 Reln Fndc1 Colq Tinagl1 Crim1 Ltbp1 Prg3 Prg4 LOC100910891 Tectb Ltbp2 Ltbp4 Col27a1 Spock3 Vwa9 Mmrn1 Vwa7 Mmrn2 Vwa1 Dspp Spon1 Spon2 Nov LOC100911714 Postn Matn1 Col23a1 Matn4 Fmod Matn2 Vit Nid2 Ctgf Matn3 Hapln3 Fn1 Nid1 Hapln1 Hapln4 Hapln2 Eln Crispld1 Amelx Cilp2 Adipoq Epyc Vwf Fbln5 Srpx2 Fbln2 Igsf10 Fga Fgg Fgb Kera Igfbp2 Lama1 Podnl1 Rangap1 Ppip5k1 Emilin2 LOC100911378 Lrg1 Emilin3 Slit2 Mepe Igfbpl1 Srgn Ogn Smoc2 Nell1 Col20a1 Hmcn1 Nell2 Lama4 Col14a1 Aspn Svep1 Col13a1 Bmper LOC100910384 Smoc1 Dmp1 Impg1 Impg2 Lgi1 Vtn Col17a1 Lgi3 Fbln7 Lgi4 Zp1 Sparcl1 Lamb3 Lamb2 Spp1 Fbln1 Mfge8 Igfals Thbs2 Optc Thbs4 Ntn3 Mfap3 Ntn1 Mfap2 Mfap5 Mfap4 Otol1 Ntn5 Col5a3 Nyx Col9a1 Col5a2 Prelp Col1a2 Col9a2 Col8a1 Vwa5a Igfbp5 Col8a2 Cilp Efemp1 Ntng1 Emilin1 Col22a1 Gldn Col11a1 Gas6 Otog Tnr Lum Esm1 Fgl2 Tsku Col16a1 Fras1 Ambn Tnn Igfbp6 Fgl1 Fbn1 Creld1 Rspo4 Lamc1 Lamc2 Rspo2 Creld2 Rspo3 Pcolce Oit3 Vwa3a Igfbp4 Ecm1 Igfbp1 Rspo1 Zp4 Lamb1 Zp3 Ibsp Sspo Col18a1 LOC102550316 Ncan Bglap Dcn Mgp Col4a2 Col4a3 Col4a1 Col4a5 LOC100911572 Wisp2 Srpx Sparc Igfbp7 Col1a1 Col3a1 Col6a2 Agrn Cyr61 Vcan Bcan Aebp1 LOC100910284 PID_NFKAPPAB_CANONICAL_PATHWAY%MSIGDB_C2%PID_NFKAPPAB_CANONICAL_PATHWAY PID_NFKAPPAB_CANONICAL_PATHWAY Ripk2 Nfkbia Tnfrsf1a Atm Ube2d3 Ran Ikbkb Erc1 Nod2 Sspo Rela Prkca Chuk Nfkb1 Traf6 Birc2 Xpo1 Bcl10 Cyld PID_PDGFRB_PATHWAY%MSIGDB_C2%PID_PDGFRB_PATHWAY PID_PDGFRB_PATHWAY Gab1 Ywhae Rhoa Pik3r5 Ywhab LOC100909750 Pten Raf1 Ywhah Rac1 Mapk1 Csk Ywhag Nras Ywhaz Prkca Myc S1pr1 Sphk1 Rasa1 Lck Actr3 Arpc4 Arpc5 Iqgap1 Fgr Cttn Hck Vav2 Pik3cg Pin1 LOC364561 Ppp2ca Nckap1 Ppp2r1a Arpc3 Arpc2 Arpc1b Crk Cbl Jund Actr2 Pik3r6 Lyn Src Abi1 Rap1b Rap1a Pik3cb Pdgfb Plcg1 Rps6ka3 Mapk10 Lrp1 Prkcd Blk Yes1 Mapk8 Abl1 Bcar1 Pdgfrb Tagln Eif2ak2 Actn4 Arap1 Ksr1 Hras Slc9a3r2 Eps8 Fos Map2k1 Sos1 Map2k2 Stat5b Srf Shc1 Stat5a Ptprj Rab4a Sfn Slc9a3r1 Kras Arhgap35 Pla2g4a Pak1 Usp6nl Stat1 Elk1 Myocd Stat3 Dnm2 Ptpn11 Sipa1 Pik3r2 Nck1 Pik3r1 Arhgdia Pik3r3 Map2k4 Mapk9 Nck2 Ptpn1 Jun Brk1 Fyn Pik3cd Map2k7 Grb2 Ptpn2 Baiap2 Grb10 Dok1 HALLMARK_INTERFERON_ALPHA_RESPONSE%MSIGDB_C2%HALLMARK_INTERFERON_ALPHA_RESPONSE HALLMARK_INTERFERON_ALPHA_RESPONSE Pnpt1 Ifi44 Parp14 Tap1 Parp12 Lap3 Ripk2 Usp18 Fam46a B2m Psmb9 Rtp4 Uba7 Lamp3 Ccrl2 Lgals3bp Oas1a Casp8 Mov10 Irf2 Gmpr Tmem140 Rnf31 Nub1 Ifit3 Ifi44l Adar Ly6e Psmb8 Cmtr1 Txnip Wars RGD1563091 LOC100911495 Trim5 Gbp2 Isg15 Ncoa7 Epsti1 Plscr1 Cnp Ifi27 Ogfr Cmpk2 Slc25a28 Irf7 Helz2 Sp110 Psme1 Lpar6 Oasl Psme2 Cd74 Ifit2 Ifitm3 Herc6 Ifitm1 Mx2 Ifitm2 Irf1 Trafd1 Ifi35 Ifih1 Ifi30 Gbp4 Trim26 Cxcl10 Dhx58 Cxcl11 Procr Parp9 Eif2ak2 Trim21 Isg20 Trim25 Csf1 Mvb12a C1s Stat2 Il4r Casp1 Irf9 Il15 Elf1 Rsad2 Psma3 Il7 Ube2l6 Cd47 BIOCARTA_CLASSIC_PATHWAY%MSIGDB_C2%BIOCARTA_CLASSIC_PATHWAY BIOCARTA_CLASSIC_PATHWAY C2 C1qa C1qb C6 C1r C1qc C4a C8a C3 C9 C1s BIOCARTA_MCALPAIN_PATHWAY%MSIGDB_C2%BIOCARTA_MCALPAIN_PATHWAY BIOCARTA_MCALPAIN_PATHWAY Pxn Hras Prkar1b Acta1 Mylk Itgb1 Prkacb Mapk1 Tln1 Ezr Capn1 Prkar2b LOC100911363 LOC100912380 Prkar2a Capns1 Cxcr3 Egfr Capn2 Ptk2 BIOCARTA_PYK2_PATHWAY%MSIGDB_C2%BIOCARTA_PYK2_PATHWAY BIOCARTA_PYK2_PATHWAY Hras Mapk14 LOC100911248 Crkl Map2k1 Sos1 Map2k2 Shc1 Map3k1 Gnaq LOC100912399 Plcg1 Ptk2b Pak1 Map2k4 Prkcb Raf1 Jun Rac1 Mapk1 Grb2 Mapk8 Src Bcar1 Prkca PID_FAS_PATHWAY%MSIGDB_C2%PID_FAS_PATHWAY PID_FAS_PATHWAY Smpd1 Bid Pik3cb Ripk1 Mapk11 Casp3 Fadd Mapk14 Cflar Birc3 Pdpk1 Fas Ezr Syk Casp8 Map3k1 LOC100912399 Mapk10 Birc2 Akt1 Pik3r2 Pik3r1 Pik3r3 Mapk9 Pik3cd Map2k7 Ikbkb Map2k6 Mapk8 Src Faslg Chuk Rfc1 Cltc HALLMARK_HEDGEHOG_SIGNALING%MSIGDB_C2%HALLMARK_HEDGEHOG_SIGNALING HALLMARK_HEDGEHOG_SIGNALING LOC100911597 Ets2 Slit1 Crmp1 Celsr1 Ophn1 Adgrg1 Amot Ldb1 Rtn1 Scg2 Vegfa Dpysl2 Nrp2 Nrp1 Nrcam Rasa1 Hey2 Nkx6-1 Hey1 Unc5c Nf1 Cdk6 Gli1 Myh9 Ptch1 Pml Shh Tle1 Tle3 Thy1 Cdk5r1 L1cam Cntfr Vldlr Plg PID_THROMBIN_PAR1_PATHWAY%MSIGDB_C2%PID_THROMBIN_PAR1_PATHWAY PID_THROMBIN_PAR1_PATHWAY F2r Rock2 Gna11 F2rl2 Gnaq Rhoa Dnm2 Zyx Nos3 Snx1 Snx2 Gnai1 Arhgdia Pik3r1 Prkcb Prkcd Dnm1 Plcb1 Plcb2 Gna14 Trpc6 Gna15 Gnai3 Gnao1 Gnai2 Plcb3 Gna12 Gnaz Arrb1 Gna13 Rock1 Prkca Gnb1 F2 Vasp Pkn1 BIOCARTA_EIF4_PATHWAY%MSIGDB_C2%BIOCARTA_EIF4_PATHWAY BIOCARTA_EIF4_PATHWAY Mtor LOC680559 Pik3r1 Eif4ebp1 Prkcb LOC100911431 Mapk14 Eif4g2 Eif4g1 Pten Pabpc1 Pdpk1 Mknk1 Mapk1 Irs1 Rps6kb1 Pdk2 Eif4a2 Prkca Eif4g3 Ghr Akt1 Eif4a1 BIOCARTA_FREE_PATHWAY%MSIGDB_C2%BIOCARTA_FREE_PATHWAY BIOCARTA_FREE_PATHWAY Gsr Gpx1 Xdh Gss Sod1 Rela Nfkb1 BIOCARTA_CK1_PATHWAY%MSIGDB_C2%BIOCARTA_CK1_PATHWAY BIOCARTA_CK1_PATHWAY Prkar1b Plcb1 Ppp2ca Prkacb Grm1 Cdk5r1 Ppp1r1b Drd2 Drd1 Csnk1d Ppp1ca Cdk5 Prkar2b Prkar2a Ppp3ca HALLMARK_NOTCH_SIGNALING%MSIGDB_C2%HALLMARK_NOTCH_SIGNALING HALLMARK_NOTCH_SIGNALING Skp1 Rbx1 Notch1 Psenen Cul1 Psen2 Fbxw11 Ccnd1 Lfng Ppard Hes1 Fzd1 Arrb1 Notch2 Wnt5a Prkca Dtx4 Kat2a Notch3 Jag1 Fzd5 Heyl Dtx2 St3gal6 PID_ERB_GENOMIC_PATHWAY%MSIGDB_C2%PID_ERB_GENOMIC_PATHWAY PID_ERB_GENOMIC_PATHWAY Zfp709 Nedd8 Smarcb1 Nr0b1 Smarce1 C3 Ncoa1 Ncoa2 Uba3 Smarca4 Ddx54 Nr0b2 Ube2m Esr2 PID_HDAC_CLASSI_PATHWAY%MSIGDB_C2%PID_HDAC_CLASSI_PATHWAY PID_HDAC_CLASSI_PATHWAY Yy1 Hdac1l Hdac2 Nfkb1 Hdac1 Prmt5 Max Sirt2 Nfkbia Smad7 Crebbp Pparg Ncor2 Rela Sspo Smurf1 Hdac4 Gata1 Prkaca Sin3a Ran Ube2i Xpo1 Stat3 LOC100911167 Hdac8 Hdac3 Nr2c1 Sap18 LOC100911453 RGD1561590 Rbbp7 Mbd3 Mbd2 Tnfrsf1a Mta2 Hdac6 Chd4 Sirt4 Chd3 Sirt6 Smg5 Sirt3 Gatad2a Gatad2b Hdac11 Wdr77 Hdac10 Ranbp2 Mxd1 Gata2 Sirt5 Fkbp3 PID_HES_HEY_PATHWAY%MSIGDB_C2%PID_HES_HEY_PATHWAY PID_HES_HEY_PATHWAY Gata1 Notch1 Myod1 Cd4 Parp1 Yy1 Camk2d Rbbp8 Kdm1a Hdac1l Cdkn1b Hey2 Hey1 Ctbp1 Stat3 Hdac1 Ghr LOC100911167 Ar Rb1 Bglap Tle1 Gaa Ncoa1 Hif1a Twist1 Ptf1a E2f1 Hes1 Arnt Gata4 Id1 Ascl1 Maml1 Runx2 Crebbp Neurog3 Ncor2 Hes6 ST_GA12_PATHWAY%MSIGDB_C2%ST_GA12_PATHWAY ST_GA12_PATHWAY Rasal1 Myef2 Nr4a3 F2rl1 Raf1 Jun Mapk1 Dlg4 Map2k5 C2 Mapk8 Src Pld3 Pld2 Pld1 F2rl2 Ephb2 F2 Vav1 Ptk2 BIOCARTA_RANMS_PATHWAY%MSIGDB_C2%BIOCARTA_RANMS_PATHWAY BIOCARTA_RANMS_PATHWAY Ran Kif15 Ranbp1 Numa1 Kpna2 Aurka Kpnb1 Tpx2 RGD1565297 BIOCARTA_RNA_PATHWAY%MSIGDB_C2%BIOCARTA_RNA_PATHWAY BIOCARTA_RNA_PATHWAY Eif2s1 Rela Chuk Tp53 Map3k14 Nfkb1 Nfkbia Eif2s2 Eif2ak2 Dnajc3 PID_CXCR3_PATHWAY%MSIGDB_C2%PID_CXCR3_PATHWAY PID_CXCR3_PATHWAY Mtor Pik3cb Mapk11 Hras Mapk14 Rictor Pdpk1 Map2k1 Map2k2 Ccl11 Kras Akt1 Pik3r2 Gnai1 Mapkap1 Pik3r1 Pik3r3 Dnm1 Cxcl9 Raf1 Pf4 Pik3cd Mapk1 Nras Map2k6 Gnai3 Gnao1 Src Gnai2 Gnaz Arrb1 Cxcr3 Cxcl10 Itgb2 Gnb1 Cxcl11 Mlst8 Cxcl13 Itgal PID_RB_1PATHWAY%MSIGDB_C2%PID_RB_1PATHWAY PID_RB_1PATHWAY Cebpa Mapk14 Smarca4 Cdkn1a Hdac1l Aatf Tbp Cdkn1b Gsc Rbp2 Atf7 Brd2 Pax3 Ubtf Ccne1 Dnmt1 Hdac1 Suv39h1 Cdk2 Rb1 LOC100909750 Raf1 E2f3 E2f1 Cdk4 Runx2 Tgfb2 Crebbp Abl1 Pparg Cdkn2a Ccnd3 Smarcb1 Mapk11 Myod1 Ccnd1 Elf1 Csf2 Mdm2 Cbx4 Mef2c Atf2 Ctbp1 Cdk6 Ckm Spi1 Skp2 Hdac3 Bglap Mapk9 Jun Ppp2ca Mitf Suv39h1l1 Ccna2 BIOCARTA_DREAM_PATHWAY%MSIGDB_C2%BIOCARTA_DREAM_PATHWAY BIOCARTA_DREAM_PATHWAY Creb1 Prkar1b Prkar2b Prkar2a Kcnip3 Jun Fos Prkacb Oprk1 Polr2a PID_TELOMERASE_PATHWAY%MSIGDB_C2%PID_TELOMERASE_PATHWAY PID_TELOMERASE_PATHWAY Rad1 Rad50 Blm Sp1 Hdac1l Hdac2 Cdkn1b Ube3a Ywhae LOC103692716 Nfkb1 Tgfb1 Hdac1 Akt1 Mre11a Hus1 LOC100909750 Max Xrcc6 Xrcc5 Mapk1 E2f1 Irf1 Atm Rps6kb1 Abl1 Mtor Sin3a Myc Fos Ccnd1 Esr1 Tert Egfr Terf1 Tnks Smad3 Sap18 Jun Acd RGD1561590 Rbbp7 Parp2 Pinx1 Il2 Smg6 Wt1 Nr2f2 Nbn Smg5 Znfx1 Hnrnpc Tinf2 LOC100911576 Ifng Pot1 Mxd1 Terf2 Terf2ip PID_ERBB1_RECEPTOR_PROXIMAL_PATHWAY%MSIGDB_C2%PID_ERBB1_RECEPTOR_PROXIMAL_PATHWAY PID_ERBB1_RECEPTOR_PROXIMAL_PATHWAY Pik3cb Hras Ptpn6 Gab1 Sos1 Tln1 Shc1 Rasa1 Plcg1 Kras Pak1 Stat1 Egfr Gsn Stat3 Ptpn11 Ptk2 Gnai1 Pik3r2 Nck1 Pik3r1 Pik3r3 Ptpn1 Nck2 Pik3cd Grb2 Mapk1 Nras Pip5k1c Gnai3 Src BIOCARTA_G1_PATHWAY%MSIGDB_C2%BIOCARTA_G1_PATHWAY BIOCARTA_G1_PATHWAY Cdkn2b Tp53 Ccnd1 Cdkn1a Hdac1l Cdkn1b Gsk3b Ccne1 Cdk6 Tgfb1 Hdac1 Skp2 Atr Cdk2 Rb1 Smad3 LOC100909750 E2f1 Tgfb3 Cdk4 Atm Tgfb2 Abl1 Cdk1 Cdkn2a Cdc25a Ccna1 Dhfr PID_ALK2_PATHWAY%MSIGDB_C2%PID_ALK2_PATHWAY PID_ALK2_PATHWAY Smad5 Smad1 Bmpr2 Amh Bmp7 Acvr1 Fkbp1a Amhr2 PID_INTEGRIN2_PATHWAY%MSIGDB_C2%PID_INTEGRIN2_PATHWAY PID_INTEGRIN2_PATHWAY Gp1ba Itgax LOC103693683 Proc Itgam F11r Plat Vcam1 Icam2 C3 Plau Spon2 Cyr61 Thy1 Cd40lg Jam3 Itgb2 Icam1 Fga Itgal Fgg Fgb F10 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES%MSIGDB_C2%SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Gab1 Irs2 Cdkn1b Creb1 Gsk3b Ywhae F2rl2 Ebp Rps6ka3 Pdk1 Akt2 Bad Akt3 Akt1 Pik3r5 Cdk2 Ifi27 Ywhab Rps6ka2 Igf1 Pten Ywhah Ywhag Gadd45a Irs1 Rps6kb1 Nolc1 Ywhaz Cdkn2a Rps6ka1 Tsc1 Tsc2 Bcl2l1 Mtor Myc Cyth3 Sos1 Pak3 Pak4 Erbb4 Shc1 Pard3 Ppp1r13b Prex1 Gsk3a Slc2a4 Sfn Pak1 Creb5 Creb3 Pak6 Pak7 Ptk2 Pak2 Ptpn1 Pard6a Pik3cd Grb2 Foxo3 Igfbp1 PID_NFKAPPAB_ATYPICAL_PATHWAY%MSIGDB_C2%PID_NFKAPPAB_ATYPICAL_PATHWAY PID_NFKAPPAB_ATYPICAL_PATHWAY Csnk2a1 Csnk2b Pik3r1 Csnk2a2 Mapk14 Nfkbia Syk Ikbkb Arrb2 Src Sspo Rela Nfkb1 Lck BIOCARTA_EPONFKB_PATHWAY%MSIGDB_C2%BIOCARTA_EPONFKB_PATHWAY BIOCARTA_EPONFKB_PATHWAY Grin1 Sod2 Rela Epo Hif1a Nfkb1 Nfkbia Arnt Cdkn1a Epor BIOCARTA_NTHI_PATHWAY%MSIGDB_C2%BIOCARTA_NTHI_PATHWAY BIOCARTA_NTHI_PATHWAY Tlr2 Mapk11 Smad3 Mapk14 Il1b Map3k7 Nfkbia Dusp1 Map2k6 Ikbkb Crebbp Tgfbr2 Rela Chuk Tgfbr1 Map3k14 Nfkb1 Myd88 BIOCARTA_CARDIACEGF_PATHWAY%MSIGDB_C2%BIOCARTA_CARDIACEGF_PATHWAY BIOCARTA_CARDIACEGF_PATHWAY Hras Prkcb Myc Jun Fos Edn1 Adam12 Agt Rela Prkca Plcg1 Nfkb1 Rhoa Egfr Ednra Ednrb Agtr1a ST_ERK1_ERK2_MAPK_PATHWAY%MSIGDB_C2%ST_ERK1_ERK2_MAPK_PATHWAY ST_ERK1_ERK2_MAPK_PATHWAY Klf6 Map2k1 Map2k2 Sos1 Creb1 Shc1 Nfkb1 Rps6ka3 Bad Creb5 Creb3 Atf1 Dusp6 Rps6ka2 Dusp9 Mos Dusp4 Mknk2 Mknk1 Grb2 Araf Mapk1 Map3k8 Kat5 Eef2k Traf3 Rap1a Rps6ka1 ST_TUMOR_NECROSIS_FACTOR_PATHWAY%MSIGDB_C2%ST_TUMOR_NECROSIS_FACTOR_PATHWAY ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tradd Ripk1 Casp3 Fadd Cflar Birc3 Casp8 Bag4 Tnfrsf1b Nfkb2 Nfkb1 Birc2 Tonsl Nr2c2 Map2k4 Nfkbil1 Map3k7 Jun Nfkbia Nfkbie Nfkbib Tnfrsf1a Ralbp1 Traf2 Map3k3 BIOCARTA_PAR1_PATHWAY%MSIGDB_C2%BIOCARTA_PAR1_PATHWAY BIOCARTA_PAR1_PATHWAY F2r Gnaq Ptk2b Rhoa Gnai1 Pik3r1 Prkcb Pik3cg Map3k7 Plcb1 Arhgef3 Arhgef2 Arhgef6 Gngt1 Arhgef7 Arhgef4 Gna12 Gna13 Arhgef5 Rock1 Prkca Gnb1 Arhgef18 F2 Arhgef11 Arhgef15 Arhgef19 ST_B_CELL_ANTIGEN_RECEPTOR%MSIGDB_C2%ST_B_CELL_ANTIGEN_RECEPTOR ST_B_CELL_ANTIGEN_RECEPTOR Prdx1 Map2k1 Sos1 Map2k2 Syk Itpka Shc1 Serpina4 Ppp1r13b Itpkb Ephb2 Nfkb2 Nfkb1 Akt2 Bad Vav1 Akt3 Tonsl Akt1 Pik3r1 Blnk Nfkbil1 Dag1 Raf1 Cd19 Pik3cd Nfat5 Nfkbia Grb2 Nfkbie Csk Mapk1 Nfkbib Lyn PID_SMAD2_3PATHWAY%MSIGDB_C2%PID_SMAD2_3PATHWAY PID_SMAD2_3PATHWAY Ctdspl Smad3 Ctdsp1 Tgfbrap1 Mapk1 Smad2 Pias4 Nup153 Kpna2 Map3k1 LOC100912399 Kpnb1 Ube2i BIOCARTA_BLYMPHOCYTE_PATHWAY%MSIGDB_C2%BIOCARTA_BLYMPHOCYTE_PATHWAY BIOCARTA_BLYMPHOCYTE_PATHWAY RT1-Db1 Cd40 Cr2 Cd80 Itgb2 Icam1 Itgal Fcgr2b Ptprc RT1-Da SA_MMP_CYTOKINE_CONNECTION%MSIGDB_C2%SA_MMP_CYTOKINE_CONNECTION SA_MMP_CYTOKINE_CONNECTION Tnfrsf1b Tgfb2 Spn Fcgr3a Il1b Cd44 Ace3 Ace Csf1 Tnfrsf8 Tnfrsf1a Tgfb1 ST_GRANULE_CELL_SURVIVAL_PATHWAY%MSIGDB_C2%ST_GRANULE_CELL_SURVIVAL_PATHWAY ST_GRANULE_CELL_SURVIVAL_PATHWAY Casp3 Parp1 Mapk8ip2 Fos Mapk8ip3 Mapk8ip1 Itpka Apc Creb1 Itpkb Gnaq Ephb2 Mapk10 Creb5 Creb3 Cerk Cxcl1 Map2k4 Asah1 Mapk9 Camp Jun Dag1 Map2k7 Mapk1 Mapk8 Cxcr2 BIOCARTA_STEM_PATHWAY%MSIGDB_C2%BIOCARTA_STEM_PATHWAY BIOCARTA_STEM_PATHWAY Il4 Il5 Cd8a Il6 Csf3 Cd4 Epo Il9 Csf2 Il7 Il2 Il11 Csf1 PID_TRKR_PATHWAY%MSIGDB_C2%PID_TRKR_PATHWAY PID_TRKR_PATHWAY Ntf4 LOC100911248 Mcf2l Crkl Faim Gab1 Maged1 Ntrk2 Ntf3 Rgs19 Dynlt1 Ngfr Plcg1 Rhoa Prkcz LOC100909750 Dock1 Rac1 Mapk1 Nras Abl1 Sqstm1 LOC100909609 Hras Ccnd1 Gab2 Map2k1 Sos1 Ntrk1 Ngf Shc1 Bdnf Matk Rasa1 Kras Stat3 Ptpn11 Rit2 Rit1 Pik3r1 Ehd4 Dnm1 Grb2 Tiam1 Prkci Crk Arhgap32 Frs2 Frs3 Ntrk3 Shc2 Rhog Rap1b Shc3 Rap1a Gipc1 Dnaja3 PID_AVB3_OPN_PATHWAY%MSIGDB_C2%PID_AVB3_OPN_PATHWAY PID_AVB3_OPN_PATHWAY Spp1 Vav3 Fos Plau Rock2 Syk Map3k1 LOC100912399 Nfkb1 Ptk2b Rhoa Gsn Pik3r1 Mmp9 Jun Rac1 Nfkbia Mapk1 Mapk8 Mmp2 Bcar1 Cd44 Rela Chuk Ilk Map3k14 SIG_BCR_SIGNALING_PATHWAY%MSIGDB_C2%SIG_BCR_SIGNALING_PATHWAY SIG_BCR_SIGNALING_PATHWAY Bcl2 Sos1 Syk Itpr1 Shc1 Itpr3 Ppp1r13b Map4k1 Gsk3b Gsk3a Cr2 Nfatc2 Nr0b2 Pdk1 Akt2 Bad Vav1 Akt3 Inpp5d Ppp3ca Akt1 Flot1 Pik3r1 Cd22 Flot2 Ppp3cb Blnk Dag1 Raf1 Cd19 Pik3cd Grb2 Csk Mapk1 Ptprc Lyn Cd81 BIOCARTA_IL10_PATHWAY%MSIGDB_C2%BIOCARTA_IL10_PATHWAY BIOCARTA_IL10_PATHWAY Stat2 Stat6 Il6 Il10 Jak1 Il10ra Hmox1 Blvra Stat5b Il10rb Blvrb Stat5a Il1a Stat1 Stat3 BIOCARTA_INTEGRIN_PATHWAY%MSIGDB_C2%BIOCARTA_INTEGRIN_PATHWAY BIOCARTA_INTEGRIN_PATHWAY Pxn Hras LOC100911248 Itgb1 Crkl Map2k1 Sos1 Tln1 Map2k2 Tns1 Shc1 LOC100911363 LOC100912380 Capns1 Rhoa Zyx Ptk2 Acta1 Jun Raf1 Fyn Csk Mapk1 Grb2 Capn1 Actn1 Mapk8 Actn2 Actn3 Src Bcar1 Rap1a Vcl Rock1 BIOCARTA_PLATELETAPP_PATHWAY%MSIGDB_C2%BIOCARTA_PLATELETAPP_PATHWAY BIOCARTA_PLATELETAPP_PATHWAY App Serpine1 F9 Plat Plau Col4a2 Col4a3 Col4a1 Col4a5 LOC100911572 F2 Plg F11 PID_HIV_NEF_PATHWAY%MSIGDB_C2%PID_HIV_NEF_PATHWAY PID_HIV_NEF_PATHWAY Casp6 Bid Tradd Casp9 Ripk1 Casp3 Fadd Bcl2 Cflar Birc3 Fas Casp8 Bag4 Dffb Nfkb1 Dffa Daxx Casp2 Cradd Nfkbia Map2k7 Tnfrsf1a Mapk8 Cycs Faslg Traf2 Apaf1 Rela Chuk Cd247 Map3k14 PID_S1P_S1P3_PATHWAY%MSIGDB_C2%PID_S1P_S1P3_PATHWAY PID_S1P_S1P3_PATHWAY Pdgfb S1pr2 S1pr1 S1pr3 Gna11 Vegfa Flt1 Gnaq Rhoa Akt3 LOC100911280 Akt1 Gnai1 Rac1 Mapk1 Gna14 Gna15 Gnai3 Src Gnao1 Gnai2 Gna12 Pdgfrb Gnaz Gna13 Cxcr4 PID_CERAMIDE_PATHWAY%MSIGDB_C2%PID_CERAMIDE_PATHWAY PID_CERAMIDE_PATHWAY Smpd1 Bid Tradd Ksr1 Ripk1 Bax Fadd Bcl2 Myc Birc3 Map2k1 Map2k2 Pdgfa Casp8 Bag4 Aifm1 Pawr Map3k1 LOC100912399 Nfkb1 Bad Prkcz Akt1 Nsmaf Rb1 Map2k4 Asah1 Prkcd Igf1 Smpd3 Sphk2 Raf1 Cradd Prkra Nfkbia Mapk1 Tnfrsf1a Mapk8 Cycs Traf2 Rela Madd Eif2ak2 Eif2a Ctsd HALLMARK_MYC_TARGETS_V1%MSIGDB_C2%HALLMARK_MYC_TARGETS_V1 HALLMARK_MYC_TARGETS_V1 LOC100910750 Prps2 Mad2l1 LOC100360453 Cad Syncrip Acp1 Got2 Rpl22 Srpk1 Eef1b2 Cct2 Vdac1 Mcm7 Rps3 Nap1l1 Apex1 Ddx18 Hdgf Hsp90ab1 Rps2 Hdac2 Snrpa Pold2 LOC100910660 Hnrnpa2b1 Hnrnpr Srsf1 Nop56 Vdac3 Cct3 Ywhae LOC100360057 LOC100360260 Nhp2 Clns1a Rnps1 Mcm5 Rrp9 Eif4h Mcm6 Slc25a3 Psmb3 LOC100911372 Eif4g2 Pabpc4 Dhx15 Srsf3 Rplp0 Tomm70a Hspd1 Psma7 Rad23b Pcna Impdh2 Mcm2 Phb2 LOC100364487 Cdk4 Ndufab1 Nolc1 Pwp1 Cct7 Tcp1 Cct5 Psmd14 Ppia Cyc1 Rpl34 Ap3s1 Iars Ncbp1 Set Ssbp1 Tufm Hnrnpu Exosc7 Cdc20 LOC100363800 Eif4a1 LOC100912604 Fbl Myc Pgk1 Smarcc1 Snrpd1 Kpna2 Xpo1 Tra2b Npm1 Cul1 Hnrpd H2afz Nme1 Srsf2 Ccna2 Odc1 Tyms Pabpc1 Eif2s2 Abce1 Pa2g4 Rfc4 Usp1 Gspt1 RGD1565297 Cct4 Cdk2 Eif3j Ube2l3 Ranbp1 Eif3d Xrcc6 Cdc45 Kpnb1 Trim28 Cbx3 Rpl18 Eif1ax Kars Prdx4 Ctps1 LOC680385 Rpl14 Etf1 Eif2s1 Snrpd2 Ppm1g Sf3b3 Psma6 Lsm7 Uba2 Psma1 Psma2 Cox5a Psma4 Gnl3 Cnbp Stard7 Ran G3bp1 Eprs Prdx3 Psmb2 mrpl9 Snrpb2 LOC683884 Aimp2 Ddx21 Mcm4 Dek Nop16 Orc2 Mrpl23 Fam120a Mrps18b Ruvbl2 Psmc4 Xpot Psmc6 Serbp1 Psmd7 Ssb C1qbp Psmd8 Rps5 Hnrnpc Rps6 Psmd1 Hddc2 LOC100911576 Eif3b Srm Glo1 Erh Sf3a1 Canx Psmd3 Prpf31 BIOCARTA_NGF_PATHWAY%MSIGDB_C2%BIOCARTA_NGF_PATHWAY BIOCARTA_NGF_PATHWAY Csnk2a1 Pik3r1 Hras Pik3cg Jun Raf1 Fos Map2k1 Grb2 Sos1 Mapk8 Ngf Shc1 Ngfr Plcg1 Elk1 BIOCARTA_CD40_PATHWAY%MSIGDB_C2%BIOCARTA_CD40_PATHWAY BIOCARTA_CD40_PATHWAY Cd40 Nfkbia Dusp1 Cd40lg Ikbkb Traf3 Ikbkap Rela Chuk Map3k1 LOC100912399 Nfkb1 Map3k14 Traf6 HALLMARK_COAGULATION%MSIGDB_C2%HALLMARK_COAGULATION HALLMARK_COAGULATION Hmgcs2 Clu Mst1 LOC100911854 Ctse Lamp2 Ctsb Mbl2 Dusp6 C3 Pf4 Rac1 Mmp2 Itih1 Fn1 Pros1 F2 Plg S100a13 Lgmn Serpina1 Proz Bmp1 Klf7 P2ry1 Arf4 Tfpi2 Cfh Plek Cpn1 Msrb2 Apoc1 Rabif Mmp8 Apoc2 Csrp1 Mmp7 Dpp4 Htra1 Anxa1 Masp2 Gp9 Furin Timp1 Olr1 Cpq Lta4h Capn5 Wdr1 Gp1ba Thbd F8 Rgn S100a1 Mmp1 F12 Tmprss6 F9 Crip2 Tf Serping1 Mep1a Gda Gnb2 Prep Cpb2 RGD1563962 Prss23 Iscu Mmp10 Mmp15 Ang2 Adam9 Mmp14 Klkb1 F13b Mmp11 Ctsl Ctsk Gng12 Pef1 C8b Timp3 C8g Usp11 Serpine1 Vwf Pdgfb Plau Klk8 C2 F2rl2 Fga Fgg Gsn Serpinb2 Lrp1 Serpinc1 Mmp9 Sirt2 Maff Cfd F3 Sparc F11 C1s F10 Casp9 Proc Plat C1qa C1r C8a C9 A2m Fyn Fbn1 Acox2 Hnf4a Sh2b2 Capn2 SIG_CHEMOTAXIS%MSIGDB_C2%SIG_CHEMOTAXIS SIG_CHEMOTAXIS Racgap1 Angptl2 Cfl1 Rock2 Arhgap1 Pak3 Pak4 Itpr1 Itpr3 Ppp1r13b Pak1 Pdk1 Akt2 Akt3 Pak6 Rps4x Sag Pak7 Akt1 Actr3 Pik3r5 Rho Pik3r1 Pak2 Cfl2 Limk1 Gdi2 Wasf1 Mylk2 Pik3cg Mylk Pten Pitx2 Pik3cd Actr2 Rock1 Arhgef11 PID_S1P_S1P4_PATHWAY%MSIGDB_C2%PID_S1P_S1P4_PATHWAY PID_S1P_S1P4_PATHWAY Gnai1 Gnai3 Gnao1 Gnai2 Gna12 Gnaz Gna13 Plcg1 Rhoa Mapk1 S1pr5 S1pr4 HALLMARK_ANDROGEN_RESPONSE%MSIGDB_C2%HALLMARK_ANDROGEN_RESPONSE HALLMARK_ANDROGEN_RESPONSE Zmiz1 Pias1 Mak B2m Pdlim5 Fads1 Adrm1 Nkx3-1 Pa2g4 Camkk2 Hmgcr Ell2 Scd1 Tmem50a Ankh Steap4 Cenpn Rps6ka3 Tmprss2 Ppap2a Elk4 Ngly1 Ncoa4 Akt1 Azgp1 Idi1 Sgk1 Maf Xrcc6 Spdef Xrcc5 Hmgcs1 Ccnd3 Tpd52 Dhcr24 Akap12 Vapa Lman1 Ccnd1 Mertk Acsl3 Abcc4 Slc38a2 Adamts1 Srf Gsr Rab4a Ptk2b Ube2i Elovl5 Cdk6 Sord Abhd2 Tnfaip8 Uap1 Appbp2 Lifr Hsd17b14 Dbi Krt8 Gpd1l Pmepa1 Insig1 Homer2 Sec24d Tsc22d1 Actn1 Zbtb10 Cdc14b Gucy1a3 Fkbp5 Gnai3 Inpp4b Hpgd Spcs3 Stk39 Ube2j1 B4galt1 Herc3 Aldh1a3 Sat1 Ndrg1 Pgm3 Srp19 Dnajb9 Slc26a2 Map7 ST_INTEGRIN_SIGNALING_PATHWAY%MSIGDB_C2%ST_INTEGRIN_SIGNALING_PATHWAY ST_INTEGRIN_SIGNALING_PATHWAY Pik3cb Itga3 Pklr Plcg1 Ephb2 Mapk10 Akt2 Akt3 Akt1 Itga4 Rho Itga11 Itga8 LOC100909750 Itga7 Dock1 Itga10 Mylk2 Itga6 Mylk Pten Raf1 Mapk1 Arhgef6 Mapk8 Arhgef7 Abl1 Itga5 Bcar1 Cdkn2a Grb7 Rock1 LOC100909609 Mapk8ip2 Angptl2 Mapk8ip3 Rock2 Mapk8ip1 Sos1 Tln1 Pak3 Pak4 Shc1 P4hb Arhgap35 Tnk2 Itgb3bp Pak1 Rala Tln2 Zyx Pak6 Arhgap26 Ptk2 Pak7 Actr3 Map2k4 Pak2 Mapk9 Map3k11 Mras Fyn Map2k7 Grb2 Crk Actn1 Actr2 Src Ilk Asap1 Vasp Cse1l Terf2ip BIOCARTA_MEF2D_PATHWAY%MSIGDB_C2%BIOCARTA_MEF2D_PATHWAY BIOCARTA_MEF2D_PATHWAY Cabin1 Prkcb Ppp3cb Mef2d Hdac2 Hdac1l LOC100911363 LOC100912380 Capns1 Prkca Nfatc2 Hdac1 Ppp3ca Capn2 HALLMARK_APICAL_JUNCTION%MSIGDB_C2%HALLMARK_APICAL_JUNCTION HALLMARK_APICAL_JUNCTION Mapk14 Itga3 Mvd Nf1 Cldn9 Gnai1 Cldn4 Cldn5 Cldn6 Cd34 Pdzd3 LOC100361457 Cercam Cldn7 Itga10 Ldlrap1 Actg1 Pten Ywhah Madcam1 LOC100911324 Skap2 Tnfrsf11b Ptprc Irs1 Rras Tubg1 Mmp2 Cldn15 Actg2 Pvrl1 Alox15b Grb7 Cldn11 Map4k2 Pvrl3 Jam3 Myl12b Nrxn2 Nrap Icam1 Mpp5 Tsc1 Cdh15 Cldn14 Cdh11 Wnk4 Amigo2 Mapk13 Tmem8b Mapk11 Bmp1 Amigo1 Myl9 Mpzl1 Vps25 Atp1a3 Mpzl2 Sympk LOC100911597 Cldn19 Tspan4 Calb2 Shroom2 Tial1 Pvrl4 Cldn18 Dhx16 Nexn Rsu1 Epb41l2 Cadm3 Icam5 Layn Rasa1 Cadm2 Cdh3 Nfasc LOC100911766 Adamts5 Evl Sirpa Flnc Cdh6 Pvrl2 Parva Myh10 Adam15 Actb Stx4 Cx3cl1 Krt31 Lima1 Dsc3 Jup Gtf2f1 Adam23 Vav2 Nf2 Acta1 Ctnna1 Itgb4 Cntn1 Cd274 Dlg1 Pbx2 Thy1 Arpc2 Crb3 Cd276 Cap1 Actn1 Nlgn3 Nlgn2 Cldn8 Rac2 Cdh1 Ctnnd1 Src Adam9 Gnai2 Msn Vasp Hadh Krt33a Krt33b Pard6g Cd209a Pik3cb Vwf Fyb Sdc3 Pfn1 Plcg1 Akt2 Akt3 Mmp9 Myh9 Crat Slit2 Actc1 Arhgef6 Speg Gamt Dmp1 Cd86 Col17a1 Kcnh2 Actn4 Lamb3 Mdk Hras Vcam1 Icam2 Itgb1 Syk Sorbs3 Shc1 Col9a1 Egfr Zyx Ptk2 Pik3r3 Slc30a3 Col16a1 Insig1 Vcan Tjp1 Fbn1 Baiap2 Actn2 Lamc2 Actn3 B4galt1 Vcl Nrtn Amh BIOCARTA_CCR3_PATHWAY%MSIGDB_C2%BIOCARTA_CCR3_PATHWAY BIOCARTA_CCR3_PATHWAY Hras Ccr3 Prkcb Limk1 Raf1 Plcb1 Map2k1 Mapk1 Cfl1 Rock2 Ccl11 Gngt1 Pik3c2g Gnaq Prkca Gnb1 Rhoa Ptk2 HALLMARK_ESTROGEN_RESPONSE_EARLY%MSIGDB_C2%HALLMARK_ESTROGEN_RESPONSE_EARLY HALLMARK_ESTROGEN_RESPONSE_EARLY Sec14l2 Celsr1 Slc2a1 Slc22a5 Rara Il17rb Nrip1 Pgr Cldn7 Hes1 Dhcr7 Blvrb Ncor2 Abca3 Il6st Fdft1 Cd44 Inhbb Tff1 Sema3b Kcnk15 Sybu Rhobtb3 Cbfa2t3 Tmem164 Akap1 Ttc39a Ovol2 Slc19a2 Myc Med24 Ccnd1 Slc1a1 Mlph Calb2 Cant1 Add3 Mybl1 Nxt1 Syt12 Slc27a2 Dhrs3 Tubb2b Slc1a4 Unc119 Siah2 Rhod Egr3 Xbp1 Elovl5 Gja1 Aqp3 Tiam1 Prss23 Rasgrp1 Tob1 Svil Opn3 Gla Tjp3 Bhlhe40 Elf3 Aldh3b1 Podxl Nbl1 Cyp26b1 Pdzk1 Mreg Rbbp8 Hr P2ry2 Fhl2 Pdlim3 LOC100910316 Nadsyn1 Fkbp4 Slc39a6 Flnb Rab31 Frk Car12 Ppif Lad1 Dynlt3 Krt18 Syngr1 Lrig1 Ugcg Slc16a1 Arl3 Itpk1 Ar Faim3 Olfm1 Wisp2 Celsr2 Wfs1 Igf1r Mybbp1a Rab17 Rps6ka2 Klf10 Abat Mpped2 Pla2g16 Snx24 Stc2 Slc37a1 Asb13 Krt15 Wwc1 Slc7a5 Myof Micb Nav2 Tmprss3 Inpp5f Aff1 Bag1 Slc7a2 Tfap2c Med13l Kcnk5 Muc1 Tbc1d30 Farp1 Fam63a Tff3 Cxcl12 Ret Scnn1a Olfml3 Pex11a Esrp2 Calcr Msmb Klk10 Bcl11b Bcl2 Anxa9 Krt13 Fos Elf1 Gab2 Papss2 Sult2b1 Cish Ptges Sfn Slc9a3r1 Reep1 Abhd2 Tpd52l1 Tiparp Tgm2 Krt8 Tsku Tpbg Klf4 Fkbp5 Scarb1 B4galt1 Areg Hspb8 Igfbp4 Slc26a2 PID_BETA_CATENIN_DEG_PATHWAY%MSIGDB_C2%PID_BETA_CATENIN_DEG_PATHWAY PID_BETA_CATENIN_DEG_PATHWAY Skp1 Cul1 Csnk1a1 Csnk1d Axin2 Apc Lrp6 Gsk3b Gsk3a Sspo Dvl1 Wnt3 Dvl3 Fzd5 Wnt3a Csnk1e BIOCARTA_BIOPEPTIDES_PATHWAY%MSIGDB_C2%BIOCARTA_BIOPEPTIDES_PATHWAY BIOCARTA_BIOPEPTIDES_PATHWAY Stat2 Stat6 Hras Mapk14 Camk2d Agtr2 Camk2g Map2k1 Sos1 Map2k2 Gna11 Stat5b Camk2a Agt Shc1 Cdk5 Stat5a Plcg1 Ptk2b Stat1 Stat3 Gnai1 Prkcb Mylk Raf1 Fyn Grb2 Mapk1 Mapk8 Gngt1 Prkca Gnb1 F2 ST_ADRENERGIC%MSIGDB_C2%ST_ADRENERGIC ST_ADRENERGIC Ccl2 Mapk14 Gna11 C2 Itpr1 Apc Itpka Itpr3 Itpkb Gnaq Mapk10 Egfr Ar Akt1 Gnai1 Kcnj3 Gast Pik3r1 Asah1 Kcnj9 Camp Dag1 Raf1 Pitx2 Ptx3 Pik3cd Kcnj5 Mapk1 Gna15 Src PID_VEGF_VEGFR_PATHWAY%MSIGDB_C2%PID_VEGF_VEGFR_PATHWAY PID_VEGF_VEGFR_PATHWAY Vegfa Vegfc Pgf Nrp2 Nrp1 Flt1 Flt4 Figf LOC100911280 PID_ATF2_PATHWAY%MSIGDB_C2%PID_ATF2_PATHWAY PID_ATF2_PATHWAY LOC497963 Ddit3 Brca1 Mapk14 Atf3 Il23a Plau Socs3 Creb1 Cul3 Nf1 Arg1 Th Rb1 Ppargc1a Ins2 Mapk1 Hes1 Gadd45a Cdk4 Mapk8 Tgfb2 Mmp2 Prkca Bcl2l1 Mapk11 Il6 Bcl2 Fos Ccnd1 Dusp1 Esr1 Atf2 H2afy Sele Hbg1 Jdp2 Ruvbl2 Csrp2 Cbfb Dusp10 Dusp5 Mapk9 Pdgfra Serpinb5 Jun Jund Junb Ccna2 Kat5 Ifng Pou2f1 PID_P38_ALPHA_BETA_PATHWAY%MSIGDB_C2%PID_P38_ALPHA_BETA_PATHWAY PID_P38_ALPHA_BETA_PATHWAY Mapk11 Ripk1 Mapk14 Dusp1 Pak3 Pak1 Rala Lck Map3k12 Pak2 Map2k4 Dusp10 Fgr Hck Dusp16 Ralb Fyn Rac1 Blk Yes1 Map2k6 Src Lyn Map3k3 Traf6 ST_G_ALPHA_S_PATHWAY%MSIGDB_C2%ST_G_ALPHA_S_PATHWAY ST_G_ALPHA_S_PATHWAY Gast Asah1 Camp Raf1 Mapk1 Snx13 Bfar C2 Src Creb1 Creb5 Creb3 Terf2ip BIOCARTA_NKCELLS_PATHWAY%MSIGDB_C2%BIOCARTA_NKCELLS_PATHWAY BIOCARTA_NKCELLS_PATHWAY Pik3r1 Ptpn6 Klrc1 B2m Itgb1 Rac1 Map2k1 Syk Ptk2b Pak1 Vav1 Lat Il18 NABA_ECM_REGULATORS%MSIGDB_C2%NABA_ECM_REGULATORS NABA_ECM_REGULATORS P4ha2 Ctse Ctsb Ngly1 Itih4 Mmp2 Itih1 F2 Plg Ctsd Serpinb8 Serpina1 Serpinb7 Bmp1 Serpinb6 Prss1 Egln3 Serpinb10 Adam17 Serpina12 Serpina11 LOC100912318 Cst7 Ctsa Cst6 Mmp8 Pcsk6 Serpinb9 Pcsk5 Mmp7 Cst5 Adamtsl5 Htra1 Ctsw Adamtsl3 Masp2 Adamtsl4 Astl Csta Serpinb1a Serpina9 Serpinb13 Cst3 Serpinb11 Timp1 Serpinb12 Adamts5 Adamtsl2 Timp2 Timp4 St14 Itih3 Adam15 Mmp1 F12 F9 Serpind1 Cst11 Serpinb5 Adam23 Serping1 Mep1a Tgm1 Cpn2 Mmp10 Hyal2 Mmp15 Hyal3 Hyal1 Adam9 Pappa Mmp14 Kazald1 Hyal4 F13b Hyal5 Mmp11 RGD1565033 Ctsl Adamdec1 Ctsk Tgm3 Tgm4 Cela3b Tgm6 Timp3 Htra3 Serpinb3a Tll2 Adamts15 Pamr1 Serpine1 Adamts16 Prss12 Ogfod1 Adam28 Adamts14 F7 Plau Loxl4 Serpina10 Cst9l Loxl1 Habp2 Adamts19 Serpinf1 Serpinf2 P3h2 P3h1 Sulf2 Serpinh1 Cstl1 Fam20b Mmp28 Fam20a Tmprss15 Adam32 Adam33 Ogfod2 Mmp21 Serpinb2 Mmp20 Sulf1 Adam30 Adam7 Ctsg Serpini2 Serpinc1 Plod1 Mmp9 Serpini1 Plod3 F13a1 Mmp16 P4ha1 Adamts9 P3h3 Mmp27 Fam20c Mmp23 Adam2 P4ha3 Plod2 Adam8 Ctsf Serpina6 Ctsc Cela2a Cd109 Serpina5 Mmp12 LOC299282 Serpina7 Mmp13 Cstb Adamts7 Adamts6 Hpse Mmp17 Mmp19 Adamts4 Cela1 F10 Adamts3 Egln2 Plat Elane Adamts1 Agt Serpina4 Tgm2 A2m Adam12 Adam18 Serpine3 Adamts12 Adam19 Ambp Ky Lox Serpine2 P4htm Adam11 PID_IFNG_PATHWAY%MSIGDB_C2%PID_IFNG_PATHWAY PID_IFNG_PATHWAY Mtor Pias1 Casp1 Irf9 Jak1 Il1b LOC100911248 Camk2d Camk2g Crkl Map2k1 Socs1 Pias4 Camk2a Map3k1 LOC100912399 Stat1 Stat3 Ptpn11 Akt1 Ptges2 Pik3r1 Dapk1 Prkcd Map3k11 Mapk1 Ifngr1 Ptpn2 Cbl Smad7 Irf1 Crebbp Rap1b Rap1a Ifng BIOCARTA_D4GDI_PATHWAY%MSIGDB_C2%BIOCARTA_D4GDI_PATHWAY BIOCARTA_D4GDI_PATHWAY Casp9 Casp3 Cycs Casp1 Apaf1 Parp1 Jun Arhgap5 Arhgdib Casp8 PID_EPHB_FWD_PATHWAY%MSIGDB_C2%PID_EPHB_FWD_PATHWAY PID_EPHB_FWD_PATHWAY Efnb2 Efnb1 Pxn Hras Map2k1 Synj1 Shc1 Rasa1 Ephb1 Ephb2 Kras Pak1 Ptk2 Nck1 Pik3r1 Ephb3 Dnm1 Tf Itsn1 Kalrn Efnb3 Rac1 Grb2 Mapk1 Crk Nras Rras Src Grb7 Rap1b Rap1a Rock1 PID_IL2_PI3K_PATHWAY%MSIGDB_C2%PID_IL2_PI3K_PATHWAY PID_IL2_PI3K_PATHWAY Mtor Smpd1 Jak3 Jak1 Bcl2 Il2rg Myc Gab2 Sos1 Sgms1 Tert Shc1 LOC103692716 Nfkb1 Ugcg Prkcz Ptpn11 Akt1 Lck Eif3a Pik3r1 LOC100911372 Rac1 Grb2 E2f1 Foxo3 Rps6kb1 Il2 Rps6 Il2ra Rela Bcl2l1 PID_INSULIN_GLUCOSE_PATHWAY%MSIGDB_C2%PID_INSULIN_GLUCOSE_PATHWAY PID_INSULIN_GLUCOSE_PATHWAY Stxbp4 Stx4 Ins2 Ywhab Insr Gys1 Ywhah Prkci Ywhag Ywhaz Vamp2 Gsk3b Slc2a4 Ppp1r3a Ywhae Sfn Ppp1cc Akt2 Rhoq Prkcz Akt1 PID_CASPASE_PATHWAY%MSIGDB_C2%PID_CASPASE_PATHWAY PID_CASPASE_PATHWAY Tfap2a Tradd Satb1 Ripk1 Slk Diablo Pidd1 Casp8 Top1 Numa1 Krt18 Gsn Gas2 LOC100911519 App Cfl2 Sptan1 Cradd Cycs Traf2 Xiap Apaf1 Madd Casp6 Bid Casp9 Casp3 Casp1 Bax Bcl2 Srebf1 Parp1 Birc3 Dffb Map3k1 LOC100912399 Birc2 Vim Dffa Ptk2 Limk1 Lmnb1 Casp4 Acta1 Casp2 Arhgdib Lmna Tnfrsf1a Lmnb2 HALLMARK_ADIPOGENESIS%MSIGDB_C2%HALLMARK_ADIPOGENESIS HALLMARK_ADIPOGENESIS Acadl Ucp2 Echs1 Me1 Omd Reep6 Cpt2 Hibch LOC100910891 Acadm Acads Dld Qdpr Esyt1 Acaa2 Sdpr Decr1 Slc1a5 Cox8a Slc25a10 Uck1 Itga7 Chchd10 Samm50 C3 Cmpk1 Adcy6 Suclg1 LOC100911730 Dhrs7b Cmbl Retn Ubqln1 Lpl Ifngr1 Ywhag Fah Agpat3 Dhcr7 Gpd2 Gadd45a Por Ndufb7 Ndufab1 Angpt1 Nmt1 Pparg Mgll Cyc1 Slc19a1 G3bp2 Sdhc Sdhb Rreb1 Mdh2 Map4k3 Pdcd4 Ndufa5 Ltc4s Cd302 Slc25a1 Angptl4 Cdkn2c Idh1 Lipe Lep Itsn1 Abca1 Hadh Adipor2 Idh3g Gpam Tob1 Adipoq Rtn3 Nabp1 Grpel1 Bckdha Ephx2 Atp5o Acly Aldoa Atl2 Sult1a1 Ech1 Marc2 Nkiras1 LOC686442 Mccc1 Abcb8 Dlat Col4a1 Lpcat3 Mrap Ak2 Dbt Ptger3 Jagn1 Aplp2 Retsat Uqcrq Taldo1 Sod1 Immt Etfb Phyh Elovl6 Coq9 Dram2 Idh3a Dgat1 Coq5 Ptcd3 Ghitm Dnajc15 Esrra Slc5a6 Agpat6 Uqcr11 Plin2 Slc27a1 Crat Mylk Fzd4 Tst Scp2 Bcl2l13 Arl4a Cat Mrpl15 Araf Elmod3 Tkt Cox6a1 Lama4 Tank Pgm1 Uqcrc1 Enpp2 Phldb1 Ppp1r15b Rab34 Bcl6 Acox1 Reep5 Apoe Chuk Ndufs3 Fam73b Stom Ppm1b Fabp4 Pqlc3 Sowahc Atp1b3 Gpx3 Sparcl1 Riok3 Sspn Mgst3 Dhrs7 Aifm1 Prdx3 Aco2 Stat5a LOC683884 Pex14 Rmdn3 Ccng2 Cox7b Cs Cd151 Lifr Ddt Pfkfb3 Scarb1 Hspb8 Pfkl Ptrf Aldh2 Gpx4 Dnajb9 Sorbs1 BIOCARTA_STATHMIN_PATHWAY%MSIGDB_C2%BIOCARTA_STATHMIN_PATHWAY BIOCARTA_STATHMIN_PATHWAY Mapk13 Prkar1b Cd2 Camk2d Camk2g Camk4 Prkacb Camk2a Cd3g Cdk1 Prkar2b Prkar2a Cd247 Cd3d Cd3e PID_HNF3A_PATHWAY%MSIGDB_C2%PID_HNF3A_PATHWAY PID_HNF3A_PATHWAY Serpina1 Sftpa1 Pisd Foxa2 Foxa3 Gcg Brca1 Fos C4bpb Sp1 Nfic Nfib Apob Foxa1 Esr1 Cdkn1b Nkx3-1 Sod1 Atp5j Prdm15 Xbp1 Ndufv3 Dscam Ar Scgb1a1 Ins2 Nrip1 Shh Jun Ap1b1 Nr2f2 Crebbp Col18a1 Vtn Tff1 Pou2f1 BIOCARTA_PDGF_PATHWAY%MSIGDB_C2%BIOCARTA_PDGF_PATHWAY BIOCARTA_PDGF_PATHWAY Stat2 Stat6 Hras Jak1 Fos Map2k1 Pdgfa Sos1 Srf Stat5b Shc1 Rasa1 Stat5a Map3k1 LOC100912399 Plcg1 Stat1 Elk1 Stat3 Csnk2a1 Pik3r1 Map2k4 Prkcb Pdgfra Pik3cg Jun Raf1 Grb2 Mapk8 Prkca HALLMARK_UNFOLDED_PROTEIN_RESPONSE%MSIGDB_C2%HALLMARK_UNFOLDED_PROTEIN_RESPONSE HALLMARK_UNFOLDED_PROTEIN_RESPONSE Atf3 Kif5b Asns Vegfa Nop56 Eef2 Nhp2 LOC680559 Rrp9 LOC100911431 Eif4g1 Nolc1 Ywhaz Iars Eif4a1 Fus Mthfd2 Aldh18a1 Ssr1 Herpud1 Ttc37 Banf1 Calr Slc1a4 Nop14 Pdia5 Pdia6 Lsm4 Srpr Fkbp14 Tatdn2 Xbp1 Tars Slc30a5 Hsp90b1 Zbtb17 Lsm1 Npm1 Atf4 H2afx Eif2ak3 Ifit1lb Nabp1 Tubb2a Dnaja4 Dcp2 Wipi1 Ero1l Dnajc3 Kdelr3 Cks1l Psat1 Tspyl2 Wfs1 Hspa9 Khsrp Hyou1 Rps14 Sec31a Ern1 Skiv2l2 Stc2 Atf6 Sec11a Cebpg Slc7a5 Hspa5 Dctn1 Serp1 Chac1 Sdad1 Exosc2 Exosc9 Exosc5 Exosc4 Eif4a2 Atp6v0d1 Pop4 Nfyb Nfya Edc4 Bag3 Ddx10 Imp3 Dcp1a Cnot4 Cnot2 Cxxc1 Ddit4 Eif4ebp1 Eif2s1 Ccl12 Shc1 Cks1b Xpot Arfgap1 Spcs3 Exoc2 Igfbp1 Gosr2 Dnajb9 BIOCARTA_TH1TH2_PATHWAY%MSIGDB_C2%BIOCARTA_TH1TH2_PATHWAY BIOCARTA_TH1TH2_PATHWAY Il4 RT1-Db1 Cd40 Il4r Cd28 Ifngr2 Ifngr1 RT1-Da Il12rb2 Cd40lg Il2 Il2ra Il12a Cd86 Ifng Il12b Il18r1 Il18 PID_HIF2PATHWAY%MSIGDB_C2%PID_HIF2PATHWAY PID_HIF2PATHWAY Serpine1 Bhlhe40 Ets1 Egln3 Egln2 Epo Vhl Sp1 Pgk1 Apex1 Eif3e Tceb1 Hif1an Epas1 Adora2a Vegfa Pou5f1 Flt1 Slc2a1 Slc11a2 Cited2 Elk1 Abcg2 LOC100911280 Efna1 Twist1 Arnt Crebbp Mmp14 PID_ARF6_TRAFFICKING_PATHWAY%MSIGDB_C2%PID_ARF6_TRAFFICKING_PATHWAY PID_ARF6_TRAFFICKING_PATHWAY Itgb1 Itga3 Mapk8ip3 Bin1 Pld2 Pld1 Slc2a4 Rala Scamp2 Acap1 Dnm2 Agtr1a Klc1 Spag9 Itga4 Itga11 Ins2 Vamp3 Exoc5 Itga8 Adrb2 Itga7 Exoc3 Tshr Itga10 LOC100360745 Itga6 Exoc6 Ctnna1 Nme1 Pip5k1c Cdh1 Ctnnd1 Itga5 Arf6 Il2ra Exoc2 Exoc7 Cltc Ednrb HALLMARK_WNT_BETA_CATENIN_SIGNALING%MSIGDB_C2%HALLMARK_WNT_BETA_CATENIN_SIGNALING HALLMARK_WNT_BETA_CATENIN_SIGNALING Notch1 Adam17 Myc Tp53 Hdac2 Wnt1 Fzd1 Lef1 Hey2 Hey1 Jag1 Skp2 Gnai1 Ptch1 Cul1 Psen2 Notch4 Ppard Ncstn Nkd1 Axin2 Maml1 Wnt6 Wnt5b Ncor2 Dkk4 Dkk1 Hdac11 Kat2a Csnk1e Tcf7 PID_NFAT_3PATHWAY%MSIGDB_C2%PID_NFAT_3PATHWAY PID_NFAT_3PATHWAY Casp3 Bax Mapk14 Bcl2 Prkaca Camk4 Ran Pim1 Gsk3b Ywhae Kpna2 Sfn Map3k1 Nfatc2 LOC100912399 Nfatc3 Prkch Bad Xpo1 Prkcz Ppp3ca Prkcq Csnk2a1 Ywhab Prkcb Mapk9 Cabin1 Prkcd Ppp3cb Csnk1a1 Mef2d Fkbp8 Ywhah Ywhag Fkbp1a Map3k8 Mapk8 Chp1 Ywhaz Crebbp Ppp3r1 Akap5 Nr4a1 Prkca Kpnb1 Rcan2 Bcl2l1 BIOCARTA_ETC_PATHWAY%MSIGDB_C2%BIOCARTA_ETC_PATHWAY BIOCARTA_ETC_PATHWAY Mt-co1 Slc25a5 Uqcrc1 Ndufa1 Cycs Sdhd Sdha Sdhc Sdhb Slc25a4 Gpd2 Atp5a1 ST_INTERFERON_GAMMA_PATHWAY%MSIGDB_C2%ST_INTERFERON_GAMMA_PATHWAY ST_INTERFERON_GAMMA_PATHWAY Reg1a Jak1 Pla2g2a Ptpru Cish Ifng Stat1 Ifngr1 Elp2 PID_ARF6_PATHWAY%MSIGDB_C2%PID_ARF6_PATHWAY PID_ARF6_PATHWAY Lhcgr Gulp1 Kif13b Pxn Acap2 Fbxo8 Cyth3 Gna11 Gnaq Egfr Acap1 Itga2b Agtr1a Nck1 Adrb2 Tshr Git1 LOC100360745 Efna1 Epha2 Gna14 Gna15 Arrb2 Src Arrb1 Arf6 Hgf Cyth2 BIOCARTA_RAB_PATHWAY%MSIGDB_C2%BIOCARTA_RAB_PATHWAY BIOCARTA_RAB_PATHWAY Rab2a Rab6a Rab3a Acta1 Rab4a Rab11a Rab27a Rab7a Rab9a Rab1a SA_REG_CASCADE_OF_CYCLIN_EXPR%MSIGDB_C2%SA_REG_CASCADE_OF_CYCLIN_EXPR SA_REG_CASCADE_OF_CYCLIN_EXPR Cdk2 Cdkn1b Ccna2 Cdkn2a Ccne1 Ccnd1 Ccne2 E2f1 Ccna1 Cdk4 Prpmp5 BIOCARTA_NFAT_PATHWAY%MSIGDB_C2%BIOCARTA_NFAT_PATHWAY BIOCARTA_NFAT_PATHWAY Hras Mapk14 Camk4 Prkacb Map2k1 Edn1 Hbegf Mef2c Agt Hand1 Calr Gsk3b Prkar2b Camk1g Camk1 Prkar2a Ctf1 Nfatc2 Nfatc4 Nfatc3 Nppa Nkx2-5 Ppp3ca Akt1 Pik3r1 Prkar1b Lif Ppp3cb Csnk1a1 Igf1 Pik3cg Acta1 Raf1 Mapk1 Gata4 Fkbp1a Rps6kb1 Mapk8 Crebbp Fgf2 F2 BIOCARTA_IL2RB_PATHWAY%MSIGDB_C2%BIOCARTA_IL2RB_PATHWAY BIOCARTA_IL2RB_PATHWAY Jak3 Hras Ptpn6 Bcl2 Jak1 Cflar Il2rg LOC100911248 Myc Fos Crkl Fas Sos1 Syk Socs1 Socs3 Stat5b Shc1 Stat5a Bad Ikzf3 Akt1 Pik3r1 Pik3cg Raf1 Grb2 Mapk1 E2f1 Irs1 Cbl Rps6kb1 Faslg Ppia Il2ra Bcl2l1 BIOCARTA_GH_PATHWAY%MSIGDB_C2%BIOCARTA_GH_PATHWAY BIOCARTA_GH_PATHWAY Pik3r1 Hras Ins2 Ptpn6 Prkcb Insr Pik3cg Raf1 Hnf1a Grb2 Map2k1 Mapk1 Sos1 Irs1 Socs1 Stat5b Srf Shc1 Slc2a4 Stat5a Prkca Plcg1 Rps6ka1 Ghr PID_INTEGRIN_A4B1_PATHWAY%MSIGDB_C2%PID_INTEGRIN_A4B1_PATHWAY PID_INTEGRIN_A4B1_PATHWAY Pxn Mdk Spp1 Adam28 Vcam1 Thbs2 Prkaca Itgb1 Prkacb Tln1 Igsf8 Ptk2b Amica1 Ptk2 Cd14 Itga4 Prkar1b Git1 Dock1 Rac1 Crk Ywhaz Src Bcar1 Abi1 Arf6 Fn1 Cd81 LOC100909609 Ptpra PID_SYNDECAN_2_PATHWAY%MSIGDB_C2%PID_SYNDECAN_2_PATHWAY PID_SYNDECAN_2_PATHWAY Hras Casp3 Bax Sdcbp Prkaca Itgb1 Csf2 Ezr Sdc2 Rasa1 Ephb2 Epb4.1 Rhoa Nf1 Tgfb1 Lama1 Prkcd Mapk1 Mapk8 Mmp2 Src Itga5 Fn1 Cav2 Trappc4 PID_IL8_CXCR1_PATHWAY%MSIGDB_C2%PID_IL8_CXCR1_PATHWAY PID_IL8_CXCR1_PATHWAY Fgr Prkcb Dnm1 Hck Pik3cg Plcb1 Pdpk1 Plcb2 Gna14 Cbl Adrbk1 Gna15 Pik3r6 Arrb2 Lyn Gnai2 Plcb3 Pld1 Arrb1 Prkca Gnb1 Cxcr1 Akt1 NABA_COLLAGENS%MSIGDB_C2%NABA_COLLAGENS NABA_COLLAGENS Col6a6 Col4a2 Col4a3 Col6a1 Col1a1 Col4a1 Col11a2 Col5a3 Col9a1 Col4a5 LOC100911572 Col5a1 Col5a2 Col1a2 Col9a2 Col3a1 Col8a1 Col8a2 Col6a2 Col27a1 Col22a1 Col11a1 Col16a1 Col20a1 Col23a1 Col14a1 Col13a1 LOC100910384 Col18a1 Col17a1 BIOCARTA_MONOCYTE_PATHWAY%MSIGDB_C2%BIOCARTA_MONOCYTE_PATHWAY BIOCARTA_MONOCYTE_PATHWAY Itga4 Itgam Cd44 Itgb1 Itgb2 Icam1 Itgal Selp Sele PID_IL27_PATHWAY%MSIGDB_C2%PID_IL27_PATHWAY PID_IL27_PATHWAY Stat2 Gata3 Tbx21 Il6 Il17a Il1b Jak1 Il12rb2 Il2 Il6st Stat5a Il12a Ifng Ebi3 Il27ra Il12b Stat1 Tgfb1 Stat3 Il18 PID_EPHA_FWDPATHWAY%MSIGDB_C2%PID_EPHA_FWDPATHWAY PID_EPHA_FWDPATHWAY LOC100911248 Vav3 Crkl Cdk5 Plcg1 Rhoa Lck Pik3r5 Fgr Hck Vav2 Pik3cg LOC100912512 Efna1 Epha1 Fyn Epha3 Efna2 Epha2 Blk Yes1 Crk Cbl Pik3r6 Src Lyn Epha7 Epha8 Ngef Epha4 Rock1 Arhgef15 BIOCARTA_IGF1R_PATHWAY%MSIGDB_C2%BIOCARTA_IGF1R_PATHWAY BIOCARTA_IGF1R_PATHWAY Pik3r1 Igf1r Hras Prkar1b Raf1 Ywhah Prkacb Grb2 Map2k1 Mapk1 Sos1 Irs1 Shc1 Prkar2b Prkar2a Rps6ka1 Bad Akt1 BIOCARTA_INTRINSIC_PATHWAY%MSIGDB_C2%BIOCARTA_INTRINSIC_PATHWAY BIOCARTA_INTRINSIC_PATHWAY F8 Serpinc1 F12 Proc F9 F2r Serping1 Col4a2 Col4a3 Col4a1 Col4a5 LOC100911572 Klkb1 Pros1 F2 Fga Fgg Fgb F11 F10 PID_AURORA_A_PATHWAY%MSIGDB_C2%PID_AURORA_A_PATHWAY PID_AURORA_A_PATHWAY Ndel1 Brca1 Prkaca Cenpa Tp53 Mdm2 Ran Gsk3b Rasa1 Ajuba Pak1 Tacc1 Akt1 Fzr1 Dlgap5 Oaz1 Ckap5 Ccnl2 Git1 Cpeb1 Aurka Nfkbia Tpx2 Aurkb Gadd45a Tacc3 Arhgef7 Cdc25b PID_A6B1_A6B4_INTEGRIN_PATHWAY%MSIGDB_C2%PID_A6B1_A6B4_INTEGRIN_PATHWAY PID_A6B1_A6B4_INTEGRIN_PATHWAY Lamb3 Rxra Hras Lamb2 Mst1 Itgb1 Shc1 Pmp22 Ywhae Sfn Rxrg Rxrb Egfr Erbb2 Mst1r Akt1 Lama1 Pik3r1 Ywhab Itga6 Itgb4 Ywhah Rac1 Grb2 Ywhag Rps6kb1 Lama4 Cdh1 Ywhaz Lamc1 Lamc2 Erbb3 Prkca Il1a Col17a1 Lamb1 PID_SMAD2_3NUCLEAR_PATHWAY%MSIGDB_C2%PID_SMAD2_3NUCLEAR_PATHWAY PID_SMAD2_3NUCLEAR_PATHWAY Serpine1 Runx1 Atf3 Runx3 Foxg1 Sp1 Dlx1 Cited1 Tgif1 Foxh1 Cdkn1a Med15 Hdac1l Hdac2 Pias4 Snip1 Gsc Creb1 Vdr Hdac1 Akt1 Tfe3 Ar E2f5 Cdk2 Irf7 Max Ncoa1 Ncoa2 Smad2 Smad7 Cdk4 Runx2 Crebbp Kat2a Dcp1a Pias3 Il5 Gata3 Il10 Cdkn2b Ifnb1 Myod1 Rbl1 Foxo1 Sin3a Myc Fos Mef2c Esr1 Atf2 Col1a2 Ctbp1 Nkx2-5 Zbtb17 Foxo4 Cbfb Smad3 Sap18 Jun Skil RGD1561590 Rbbp7 Foxo3 Lamc1 Hnf4a HALLMARK_ESTROGEN_RESPONSE_LATE%MSIGDB_C2%HALLMARK_ESTROGEN_RESPONSE_LATE HALLMARK_ESTROGEN_RESPONSE_LATE Hmgcs2 Ptpn6 Perp Fabp5 Aldh3a2 Slc22a5 Sgk1 Il17rb Nrip1 Pgr Dhcr7 Cdc6 Blvrb Ncor2 Abca3 Il6st Fdft1 Cd44 Tff1 Sema3b Pdcd4 Cdc20 Serpina1 Mettl3 Mapk13 Llgl2 Tsta3 Unc13b Rnaseh2a Tfpi2 Jak1 Slc2a8 Lsr Ovol2 Cyp4f40 Pkp3 Gale Ccnd1 Ltf Nab2 Rabep1 Add3 Igsf1 Snx10 Nxt1 Plac1 Nmu Slc27a2 Pcp4 Dusp2 Tspan13 Cacna2d2 Slc1a4 Prkar2b Ass1 Idh2 Atp2b4 Siah2 Klk11 Chst8 Egr3 Xbp1 Car2 Elovl5 St14 Kif20a Slc29a1 S100a9 Tiam1 Prss23 Cdh1 Tob1 Opn3 Gla Tjp3 Aldh3b1 Nbl1 Cyp26b1 Pdzk1 Rbbp8 Hr Pdlim3 Fkbp4 Flnb Rab31 Ptger3 Frk Ppif Car12 Cxcl14 Dynlt3 Etfb Slc16a1 Plk4 Arl3 Itpk1 Olfm1 Wisp2 Celsr2 Tnnc1 Wfs1 Large Th Rps6ka2 Pla2g16 Tst Slc7a5 Myof Micb Tmprss3 Ascl1 Gjb3 Aff1 Bag1 Dnajc12 Hspa4l Tfap2c Batf Mest Serpina5 Kcnk5 Plxnb1 LOC299282 St6galnac2 Dlg5 Farp1 Agr2 Gal Tff3 Trim29 Cxcl12 Ret Tpsb2 Scnn1a Gper1 Isg20 Btg3 Ccna1 Emp2 Calcr Impa2 Mdk Klk10 Bcl2 Anxa9 Krt13 Fgfr3 Fos Papss2 Sult2b1 Cish Gins2 Ptges Slc9a3r1 Sfn Ugdh Sord Abhd2 Tpd52l1 Homer2 Tpbg Klf4 Fkbp5 Lamc2 Scarb1 Acox2 Areg Hspb8 Id2 Igfbp4 Ckb Slc26a2 BIOCARTA_GSK3_PATHWAY%MSIGDB_C2%BIOCARTA_GSK3_PATHWAY BIOCARTA_GSK3_PATHWAY Gnai1 Cd14 Pik3r1 Tollip Gja1 Tlr4 Tirap Ccnd1 Ppp2ca Pdpk1 Wnt1 Apc Fzd1 Lef1 Gsk3b Rela Dvl1 Nfkb1 Lbp Eif2ak2 Akt1 Myd88 BIOCARTA_AKAP13_PATHWAY%MSIGDB_C2%BIOCARTA_AKAP13_PATHWAY BIOCARTA_AKAP13_PATHWAY Gna12 Prkar2b Gna13 Prkar2a Lpar2 Prkacb Rhoa Lpar1 Lpar3 BIOCARTA_CFTR_PATHWAY%MSIGDB_C2%BIOCARTA_CFTR_PATHWAY BIOCARTA_CFTR_PATHWAY Prkar1b Adrb2 Prkar2b Prkar2a Slc9a3r1 Prkacb Ezr BIOCARTA_EDG1_PATHWAY%MSIGDB_C2%BIOCARTA_EDG1_PATHWAY BIOCARTA_EDG1_PATHWAY Gnai1 Smpd1 Pik3r1 Asah1 Prkcb Pdgfra Pik3cg Plcb1 S1pr1 Rac1 Mapk1 Pdgfa Sphkap Sphk1 Gngt1 Src Prkca Gnb1 Smpd2 Rhoa Akt1 Ptk2 PID_BCR_5PATHWAY%MSIGDB_C2%PID_BCR_5PATHWAY PID_BCR_5PATHWAY Ptpn6 Mapk14 Camk2g Cd72 Bcl2a1 Dapp1 Pik3ap1 Nfkb1 Akt1 Ppp3cb Blnk Map3k7 Raf1 Pten Cd19 Nfkbia Rac1 Csk Mapk1 Nfkbib Fcgr2b Ptprc Ikbkb Mapk8 Rela Chuk Traf6 Hras Ets1 Fos Pdpk1 Map2k1 Sos1 Syk Shc1 Map4k1 Cd79b Rasa1 Cd79al Map3k1 LOC100912399 Inpp5d Elk1 Bcl10 Ppp3ca Csnk2a1 Cd22 Pik3r1 Vav2 Jun Grb2 Lyn Dok1 PID_CD40_PATHWAY%MSIGDB_C2%PID_CD40_PATHWAY PID_CD40_PATHWAY Il4 Mapk11 Fcamr Cd40 Jak3 Mapk14 Myc Birc3 Cd40lg Stat5a Map3k1 LOC100912399 Nfkb1 Mapk10 Cblb Birc2 Tdp2 Akt1 C4bpa Map2k4 Mapk9 Jun Nfkbia Mapk8 Traf2 Traf3 Rela Map3k14 Traf6 Bcl2l1 BIOCARTA_FIBRINOLYSIS_PATHWAY%MSIGDB_C2%BIOCARTA_FIBRINOLYSIS_PATHWAY BIOCARTA_FIBRINOLYSIS_PATHWAY Serpine1 F13a1 F2r Plat Plau Fga F2 Plg Fgg Cpb2 Serpinb2 Fgb HALLMARK_INTERFERON_GAMMA_RESPONSE%MSIGDB_C2%HALLMARK_INTERFERON_GAMMA_RESPONSE HALLMARK_INTERFERON_GAMMA_RESPONSE Ccl5 Ptpn6 Ripk2 B2m Socs1 Socs3 Gzma Psmb10 Plscr1 Mt2A Cxcl9 Psme1 Ptgs2 Irf1 Upp1 Cxcl10 Cxcl11 Bpgm Icam1 Selp Myd88 Mthfd2 Cd40 Il4r Cfh Psma3 Il10ra Xcl1 Serping1 Casp4 Cd274 Hif1a Itgb7 Ube2l6 RT1-Ba Tapbp RT1-M3-1 LOC100909593 Lats2 Pnpt1 Ifit1lb Ifi44 Tap1 Ripk1 Parp14 Tnfsf10 Parp12 Lap3 Usp18 Psmb9 Rtp4 Cdkn1a Lgals3bp Casp8 C2 Irf2 Rnf31 Ifit3 Sod2 Ifi44l Adar Ly6e Psmb8 RT1-DMa Nfkb1 Cmtr1 Txnip Wars Isoc1 LOC100911495 Isg15 Epsti1 Ifi27 Fpr1 Ogfr Cmpk2 Pml Slc25a28 Irf7 Helz2 Sp110 Oasl Psme2 Arl4a Ifit2 Cd74 Nfkbia Ifitm3 Herc6 Ifitm2 Lcp2 Mx2 Trafd1 Ifi35 Ifih1 Ifi30 Mvp Gbp4 Trim26 Dhx58 Cd86 Eif2ak2 Trim21 Isg20 Trim25 Gch1 C1s Vamp5 Vamp8 Stat2 XAF1 RT1-Db1 Pnp Casp3 Il6 LOC498435 Irf9 Casp1 Nod1 Sppl2a Vcam1 Il15 Ciita Sspn Fas Psma2 Lysmd2 Cmklr1 Ccl12 Slamf7 Mpa2l Pim1 Il18bp St3gal5 Csf2rb Zbp1 Psmb2 Gpr18 Irf8 Rsad2 Eif4e3 Ido1 Rapgef6 Peli1 Tor1b Pla2g4a Bank1 Stat1 Nup93 Sectm1a Stat3 Fcgr1a Rbck1 C1r Ptpn1 Fgl2 Tnfaip2 Mettl7b Cd69 Ccl7 Irf5 Samhd1 Il7 Btg1 Ptpn2 Oas2 Cd38 Nampt Znfx1 Pfkp PID_TAP63_PATHWAY%MSIGDB_C2%PID_TAP63_PATHWAY PID_TAP63_PATHWAY Smarcd3 Igfbp3 Clca2 Aen Ogg1 Noc2l Bax Mfge8 Dicer1 Evpl Spata18 Hbp1 Tp63 Cables1 Traf4 Itga3 Ssrp1 Sp1 Mdm2 Fas Perp Cdkn1a Gpx2 Dhrs3 Nqo1 Fdxr Vdr Egr2 Jag1 Gdf15 Ada Plk1 Flot2 Pml Shh LOC100909750 Prkcd Serpinb5 Itgb4 Wwp1 Gadd45a Ikbkb Tfap2c Abl1 Cdkn2a Sspo Chuk PID_DNA_PK_PATHWAY%MSIGDB_C2%PID_DNA_PK_PATHWAY PID_DNA_PK_PATHWAY Csnk2a1 Csnk2b Csnk2a2 Xrcc6 Xrcc5 Xrcc4 Prkdc Lig4 Poll Aplf Aptx Pnkp Polm Nhej1 Dclre1c Dntt BIOCARTA_TNFR2_PATHWAY%MSIGDB_C2%BIOCARTA_TNFR2_PATHWAY BIOCARTA_TNFR2_PATHWAY Ripk1 Lta Nfkbia Dusp1 Tank Tnfrsf1b Ikbkb Traf2 Traf3 Rela Ikbkap Chuk Map3k1 LOC100912399 Nfkb1 Map3k14 BIOCARTA_TFF_PATHWAY%MSIGDB_C2%BIOCARTA_TFF_PATHWAY BIOCARTA_TFF_PATHWAY Casp9 Pik3r1 Hras Pik3cg Itgb1 Mapk1 Grb2 Sos1 Shc1 Cycs Apaf1 Rhoa Egfr Bad Ghr Akt1 Ptk2 BIOCARTA_IL22BP_PATHWAY%MSIGDB_C2%BIOCARTA_IL22BP_PATHWAY BIOCARTA_IL22BP_PATHWAY Stat2 Stat6 Jak3 Jak1 Il10ra Il22ra1 Il22ra2 Socs3 Stat5b Stat5a Il22 Stat1 Stat3 BIOCARTA_CSK_PATHWAY%MSIGDB_C2%BIOCARTA_CSK_PATHWAY BIOCARTA_CSK_PATHWAY RT1-Db1 Prkar1b Cd4 Zap70 Prkacb Csk Ptprc RT1-Da Gngt1 Cd3g Crebbp Prkar2b Prkar2a Gnb1 Cd247 Cd3d Lck Cd3e PID_IL5_PATHWAY%MSIGDB_C2%PID_IL5_PATHWAY PID_IL5_PATHWAY Stat5b Il5 Pim1 Pik3r1 Lyn Csf2rb Cish Stat5a Sdcbp Grb2 Il5ra Ptpn11 PID_P38_MK2_PATHWAY%MSIGDB_C2%PID_P38_MK2_PATHWAY PID_P38_MK2_PATHWAY Th Mapk11 Etv1 Ywhab Hspb1 Mapk14 Raf1 Ywhah Ywhag Srf Ywhaz Creb1 Cdc25b Ywhae Sfn Lsp1 Mapkapk2 Mapkapk3 Tsc2 BIOCARTA_TOLL_PATHWAY%MSIGDB_C2%BIOCARTA_TOLL_PATHWAY BIOCARTA_TOLL_PATHWAY Ppara Mapk14 Fos Tlr3 Tlr6 Map3k1 LOC100912399 Nfkb1 Elk1 Tlr2 Pglyrp1 Ecsit Cd14 Tlr7 Tollip Map2k4 Tlr4 Tirap Jun Map3k7 Nfkbia Tab2 Ikbkb Map2k6 Mapk8 Rela Chuk Map3k14 Traf6 Eif2ak2 Myd88 HALLMARK_INFLAMMATORY_RESPONSE%MSIGDB_C2%HALLMARK_INFLAMMATORY_RESPONSE HALLMARK_INFLAMMATORY_RESPONSE Ccl5 Csf3 Ripk2 Il1r1 Axl Hbegf Adrm1 Rgs1 Tlr2 Pik3r5 Atp2b1 Cd14 Csf3r Ccl24 Ccl22 Ldlr Cxcl9 Raf1 Ccl20 Ifngr2 Acvr1b Irf1 Osmr Ccl17 Itga5 Cxcl10 Cxcl11 Ebi3 Icam1 Il1a Fzd5 Cd82 Csf1 Inhba Cd40 Il4r Psen1 Myc Klf6 Sphk1 Vip Timp1 Slc11a2 Ptpre Olr1 Lck Gp1ba Cx3cl1 Lif Cxcl6 Il10ra Mep1a Hif1a Abca1 Gna15 Cd70 Irak2 Gnai3 Pcdh7 Lyn Ndp Abi1 Slc31a2 Mmp14 Rhog Slc31a1 Adgre1 Btg2 Sema4d Tapbp Ahr Ptafr Kcnmb2 Best1 Mxd1 Clec5a Ptger4 Ptger2 Rasgrp1 LOC100909913 Slc4a4 Serpine1 Tacr3 Tnfsf10 Gabbr1 Bdkrb1 Tacr1 Gpr183 Slamf1 Pdpn Hrh1 Rtp4 Dcbld2 Npffr2 Oprk1 P2rx4 Lamp3 P2ry2 Ccrl2 P2rx7 Cdkn1a Atp2c1 Scn1b Ros1 Prok2 Tnfrsf9 Cd55 Tlr3 Marco Gpr132 Msr1 C3ar1 Rgs16 Rnf144b Adm Ly6e Ffar2 Cd48 Nfkb1 Itgb8 Ccr7 Sgms2 Has2 Kcnj2 Fpr1 Nmur1 Emp3 Irf7 Icoslg Lpar1 Mefv Nfkbia Ifitm1 Nlrp3 Lcp2 Aplnr F3 Slc7a2 Slc7a1 Rela Acvr2a Eif2ak2 Gch1 Atp2a2 Ptgir Il6 Il10 Il1b Il15 Ifnar1 Lta Vimp Edn1 Cmklr1 Ccl12 Osm Tnfrsf1b Adora2b Nod2 Tnfsf15 Sele Ereg Cd69 Ccl7 Cybb Tpbg Nampt Il12b Il18r1 Il18 ST_IL_13_PATHWAY%MSIGDB_C2%ST_IL_13_PATHWAY ST_IL_13_PATHWAY Il13ra1 Il4r Jak1 Il13 Il13ra2 LOC100360218 PID_CD8_TCR_DOWNSTREAM_PATHWAY%MSIGDB_C2%PID_CD8_TCR_DOWNSTREAM_PATHWAY PID_CD8_TCR_DOWNSTREAM_PATHWAY Cd8a Hras B2m Il2rg Ifnar1 Fos Map2k1 Cd8b Map2k2 Tnfrsf9 Nfatc2 Ptpn7 Kras Nfatc3 Stat1 Elk1 Ppp3ca Prkcq LOC100912356 Egr4 Tnfrsf4 Prkcb Mapk9 Ppp3cb Egr1 Jun Raf1 Mapk1 Nras Junb Il2 Mapk8 Cd3g Faslg Ppp3r1 Il2ra Prkca Ifng Cd247 Cd3d Fosl1 Cd3e BIOCARTA_IL1R_PATHWAY%MSIGDB_C2%BIOCARTA_IL1R_PATHWAY BIOCARTA_IL1R_PATHWAY Il6 Mapk14 Ifnb1 Il1b Il1r1 Map3k1 LOC100912399 Nfkb1 Tgfb1 Ecsit Tollip Il1rap Jun Map3k7 Nfkbia Tgfb3 Irak3 Ikbkb Map2k6 Mapk8 Irak2 Tgfb2 Il1rn Rela Chuk Map3k14 Traf6 Il1a Myd88 BIOCARTA_CCR5_PATHWAY%MSIGDB_C2%BIOCARTA_CCR5_PATHWAY BIOCARTA_CCR5_PATHWAY Ccl4 Mapk14 Prkcb Jun Fos Ccl12 Mapk8 Ccr5 Cxcr4 Gnaq Prkca Plcg1 Cxcl12 Ptk2b BIOCARTA_CDK5_PATHWAY%MSIGDB_C2%BIOCARTA_CDK5_PATHWAY BIOCARTA_CDK5_PATHWAY Ngf Hras Cdk5 Egr1 Ngfr Raf1 Mapk1 Cdk5r1 Map2k1 Map2k2 BIOCARTA_LAIR_PATHWAY%MSIGDB_C2%BIOCARTA_LAIR_PATHWAY BIOCARTA_LAIR_PATHWAY C6 Itga4 Il6 Vcam1 C3 Selplg Itgb1 Itgb2 Icam1 Il1a Itgal Selp PID_RAS_PATHWAY%MSIGDB_C2%PID_RAS_PATHWAY PID_RAS_PATHWAY Rasgrp1 Lgals3 Rasal1 Hras Prkcb Grb2 Sos1 Nras Rras Lgals1 Rin1 Rasa1 LOC100911794 Prkca Rasgrp4 Kras Rasgrp2 Rasgrp3 Nf1 Rabgef1 Prkcz Syngap1 Rasa2 Plce1 PID_HEDGEHOG_2PATHWAY%MSIGDB_C2%PID_HEDGEHOG_2PATHWAY PID_HEDGEHOG_2PATHWAY Pik3r1 Gli2 Ptch1 Lrp2 Shh Dhh Cdon Boc Smo Adrbk1 Tgfb2 Arrb2 Ihh Lrpap1 Hhip Akt1 PID_VEGFR1_PATHWAY%MSIGDB_C2%PID_VEGFR1_PATHWAY PID_VEGFR1_PATHWAY Nck1 Pik3r1 Pgf Prkcb Prkaca Hif1a Pdpk1 Mapk1 Cbl Vegfa Shc2 Nrp2 Nrp1 Rasa1 Flt1 Prkca LOC103692716 Plcg1 Cd2ap Nos3 Ptpn11 Akt1 LOC100911280 BIOCARTA_GABA_PATHWAY%MSIGDB_C2%BIOCARTA_GABA_PATHWAY BIOCARTA_GABA_PATHWAY Gabra1 Gabra6 Gabra5 Gabarap Src Dnm1 Gabra2 Gabra4 PID_ERBB1_INTERNALIZATION_PATHWAY%MSIGDB_C2%PID_ERBB1_INTERNALIZATION_PATHWAY PID_ERBB1_INTERNALIZATION_PATHWAY Pik3cb Hras Ube2d1 Sos1 Ube2d3 Synj1 Shc1 Kras Lrig1 Tsg101 Cblb Egfr LOC100910792 Ptk2 LOC100909679 Pik3r2 Chmp3 Epn1 Pik3r1 Pik3r3 Spry2 Stambp Zfyve28 Dnm1 Amph Sh3kbp1 Usp8 Itsn1 Raf1 Pik3cd Grb2 Cbl Nras Arhgef7 Src Sh3gl2 PID_IL3_PATHWAY%MSIGDB_C2%PID_IL3_PATHWAY PID_IL3_PATHWAY Pik3r1 Il3ra Prkaca Gab2 Prkacb Cnksr1 Srp9 Grb2 Ywhag Id1 Hdac1l Stat5b Osm Ywhaz Pim1 Shc1 Csf2rb Cish Stat5a Bcl2l1 Inpp5d Hdac1 Ptpn11 BIOCARTA_TCRA_PATHWAY%MSIGDB_C2%BIOCARTA_TCRA_PATHWAY BIOCARTA_TCRA_PATHWAY RT1-Db1 Cd3g Cd4 Zap70 Fyn Cd247 Cd3d Ptprc Lck RT1-Da Cd3e BIOCARTA_VITCB_PATHWAY%MSIGDB_C2%BIOCARTA_VITCB_PATHWAY BIOCARTA_VITCB_PATHWAY Slc23a2 Col4a5 LOC100911572 Slc2a1 P4hb Slc2a3 Col4a2 Col4a3 Col4a1 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES%MSIGDB_C2%SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Flna Angptl2 Cfl1 Rock2 Pfn1 Pak3 Pak4 Pak1 Pak6 Rps4x Flnc Pak7 Akt1 Actr3 Rho LOC100361457 Pak2 Cfl2 Gdi2 Limk1 Wasf1 Mylk2 Mylk Actg1 Actr2 Pfn2 LOC100909840 Fscn2 Fscn3 Actg2 Rock1 Vasp PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY%MSIGDB_C2%PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY LOC497963 Ddit3 Mapk11 Eif4ebp1 Mapk14 Hbp1 Tp53 Slc9a1 Mapkapk5 Mef2c Esr1 Creb1 Atf2 Mapkapk2 Mapkapk3 Pla2g4a Elk4 Csnk2a1 Csnk2b Atf1 Ppargc1a Csnk2a2 Hspb1 Krt8 Ptgs2 Jun Atf6 Mknk1 Mitf Usf1 Rps6ka5 BIOCARTA_AKAP95_PATHWAY%MSIGDB_C2%BIOCARTA_AKAP95_PATHWAY BIOCARTA_AKAP95_PATHWAY Ppp1ca Ncapd2 Prkar2b Cdk1 Prkar2a Ddx5 Akap8 Ppp2ca Prkacb PID_ILK_PATHWAY%MSIGDB_C2%PID_ILK_PATHWAY PID_ILK_PATHWAY Ppp1r12a Pxn Myl9 Rictor Parp1 Ppp1r14a Ppp1r14c Ccnd1 Ilkap Ppp1r14b Git2 Ruvbl1 Cdc37 Zeb1 Tns1 Naca Parvb Lims2 Creb1 Snai1 Gsk3b Elmo2 LOC103692716 Xpo1 Zyx Akt1 Parva Ruvbl2 Iqgap1 Ckap5 Nck2 Aurka Jun Rac1 Actn1 Tacc3 Arhgef6 Arhgef7 Rhog Diaph1 Ilk PID_SYNDECAN_1_PATHWAY%MSIGDB_C2%PID_SYNDECAN_1_PATHWAY PID_SYNDECAN_1_PATHWAY Ccl5 Ppib Sdcbp Prkaca Bsg Col4a3 Col6a1 Col1a1 Mmp7 Col4a1 Col11a2 Col9a1 Col4a5 LOC100911572 Col5a1 Col5a2 Col1a2 Col9a2 Col3a1 Col8a1 Col8a2 Tgfb1 Col6a2 Col11a1 Mmp9 Mmp1 Col16a1 Mapk1 Col14a1 Col13a1 Hpse Hgf Col17a1 BIOCARTA_ARAP_PATHWAY%MSIGDB_C2%BIOCARTA_ARAP_PATHWAY BIOCARTA_ARAP_PATHWAY Cyth3 Arfgap1 Cltb Gpld1 Kdelr1 Cyth4 Cyth1 Arfgef1 Cyth2 Kdelr2 Kdelr3 Arfgef2 Gbf1 HALLMARK_IL2_STAT5_SIGNALING%MSIGDB_C2%HALLMARK_IL2_STAT5_SIGNALING HALLMARK_IL2_STAT5_SIGNALING Col6a1 Socs1 Nrp1 Gadd45b Alcam Ppap2a Tnfrsf8 Rragd Plscr1 Slc1a5 Il3ra Tlr7 Tnfrsf21 Itga6 Nfil3 Ifngr1 Fah Cdc6 Il1r2 Cd44 Cxcl10 Selp Csf1 Ahcy Serpinb6 Il4r Myc Cst7 Klf6 Dhrs3 Furin Cd79b Abcb1a Xbp1 Car2 Drc1 Hopx S100a1 LOC100910454 Irf6 Umps Lif Smpdl3a Lrrc8c Il10ra Slc29a2 Glipr2 Ckap4 Cd83 Twsg1 Tiam1 Ager Capn3 Amacr Gpr83 Il2ra Batf3 Hipk2 Ahr Odc1 Cd81 Mxd1 Pou2f1 Ptger2 Phlda1 Swap70 Slc39a8 Enpp1 Tnfsf10 Bhlhe40 N6amt2 Gucy1b3 Etv4 Phtf2 Akap2 Plec Bmpr2 Ttc39b Cdcp1 Praf2 P2rx4 Nfkbiz Rabgap1l Dcps Mettl20 Tnfrsf9 She Galm St3gal4 Pus1 Bmp2 Aplp1 Gpr65 Ikzf2 Rgs16 Pdcd2l F2rl2 Ccne1 Nop2 Scn9a Cd48 Mapkapk2 Igf2r Lrig1 Dennd5a Penk LOC100911495 Map6 Snx14 Eno3 Ncs1 Serpinc1 Igf1r Tnfrsf4 Ptch1 Prnp Capg Plin2 Myo1c P4ha1 Slc2a3 Arl4a Ifitm3 Map3k8 Maff Fam126b Nt5e Wls Ccr4 Batf Ptrh2 Anxa4 Muc1 Syt11 Cyfip1 Gbp4 Emp1 Ccnd3 Cd86 Rhoh Pth1r Spry4 Plagl1 Bcl2l1 Lclat1 LOC100911721 Gata1 Pnp Casp3 Spp1 Il10 Bcl2 Il13 Csf2 Tnfrsf1b Pim1 Hk2 Uck2 Irf8 Cish Spred2 Rhob Prkch LOC100911167 Tgm2 Fgl2 Gabarapl1 Gsto1 Rora Adam19 Ecm1 Ndrg1 Il18r1 Gpx4 BIOCARTA_IL2_PATHWAY%MSIGDB_C2%BIOCARTA_IL2_PATHWAY BIOCARTA_IL2_PATHWAY Csnk2a1 Jak3 Hras Jak1 Il2rg Raf1 Jun Fos Grb2 Map2k1 Sos1 Syk Stat5b Mapk8 Il2 Shc1 Il2ra Stat5a Elk1 Lck SA_PROGRAMMED_CELL_DEATH%MSIGDB_C2%SA_PROGRAMMED_CELL_DEATH SA_PROGRAMMED_CELL_DEATH Bid Ces1d Casp9 Bak1 Bax Bcl2 Apaf1 Bcl2l11 Casp8ap2 Bad Bcl2l1 Bcl10 HALLMARK_SPERMATOGENESIS%MSIGDB_C2%HALLMARK_SPERMATOGENESIS HALLMARK_SPERMATOGENESIS Tnni3 Vdac3 Slc12a2 Cdkn3 Cdk1 Jam3 Ttk Kif2c Ldhc Prkar2a Pebp1 Ezh2 Bub1 Csnk2a2 Nf2 Aurka Nos1 Rad17 Ace3 Camk4 Ace Ybx2 She Slc2a5 Rfc4 Taldo1 Gapdhs Ide Zc2hc1c Il13ra2 Tktl1 Arl4a Adam2 Ift88 Sycp1 Ip6k1 Hspa4l Naa11 Coil Tekt2 Dnajb8 Theg Topbp1 Ccna1 Spata6 Npy5r Mtor Scg5 Mlf1 Htr5a Gfi1 Gsg1 Chfr Lpin1 Tnp1 Pdha2 Tnp2 Clpb Tsn Pcsk4 Gstm5 Hist1h1t Snap91 Alox15 Hspa2 Ddx25 Nphp1 Zc3h14 Adad1 Acrbp Tcp11 Nefh Cnih2 Strbp Hoxb1 Psmg1 Scg3 Actl7b Grm8 Pias2 Mllt10 Odf1 Zpbp Gad1 Mtnr1a Cct6b Tle4 Clgn Phf7 Gmcl1 Tuba3a Stam2 Art3 Dpep3 Parp2 Dmc1 Gpr182 Dcc Ddx4 Tuba3b Phkg2 Dmrt1 Il12rb2 Mast2 Prm2 Elovl3 Pgk2 Acrv1 Pcsk1n Chrm4 Tulp2 Pomc Znrf4 Adcyap1 Pgs1 Map7 LOC100911286 PID_LYMPH_ANGIOGENESIS_PATHWAY%MSIGDB_C2%PID_LYMPH_ANGIOGENESIS_PATHWAY PID_LYMPH_ANGIOGENESIS_PATHWAY Itga4 Pik3r1 Mapk11 Map2k4 Mapk14 Itgb1 Grb2 Mapk1 Sos1 Crk Figf Col1a1 Vegfc Creb1 Shc1 Itga5 Col1a2 Fn1 Rps6ka1 Flt4 Akt1 BIOCARTA_GPCR_PATHWAY%MSIGDB_C2%BIOCARTA_GPCR_PATHWAY BIOCARTA_GPCR_PATHWAY Gnai1 Hras Prkar1b Prkcb Ppp3cb Raf1 Jun Fos Prkacb Map2k1 Gngt1 Creb1 Prkar2b Prkar2a Gnaq Prkca Nfatc2 Plcg1 Gnb1 Nfatc4 Nfatc3 Rps6ka3 Elk1 Ppp3ca PID_IL1_PATHWAY%MSIGDB_C2%PID_IL1_PATHWAY PID_IL1_PATHWAY Casp1 Il1b Il1r1 Erc1 Ube2n Nfkb1 Prkcz Pik3r1 Tollip Ticam2 LOC100362142 Il1rap Jun Map3k7 Prkci Tab2 Irak3 Map2k6 Ikbkb Mapk8 Il1r2 Il1rn Map3k3 Rela Chuk Irak4 Ube2v1 LOC100912618 Sqstm1 Traf6 Il1a Myd88 PID_RXR_VDR_PATHWAY%MSIGDB_C2%PID_RXR_VDR_PATHWAY PID_RXR_VDR_PATHWAY Rarg Fam120b Rxra Bcl2 Ppara Srebf1 Thrb Ncoa1 Abca1 Ppard Nr1h3 Nr1h2 Rps6kb1 Med1 Ncor2 Pparg Vdr Nr4a1 Nr1h4 Rxrg Rxrb Tgfb1 Rara Thra PID_IL2_1PATHWAY%MSIGDB_C2%PID_IL2_1PATHWAY PID_IL2_1PATHWAY Mapk14 Irs2 Socs3 Socs1 Mapkapk2 Rhoa Cdk2 Raf1 Stam Mapk1 Irs1 Nras Mapk8 Dok2 Mapk11 Hras Jak3 Bcl2 Jak1 Il2rg Myc Fos Gab2 Map2k1 Sos1 Map2k2 Syk Stat5b Shc1 Cish Rasa1 Stat5a Kras Ptk2b Stat1 Stat3 Ikzf3 Lck Ptpn11 Pik3r1 Prkcb Mapk9 Stam2 Jun Fyn Grb2 Il2 Il2ra Ifng PID_HNF3B_PATHWAY%MSIGDB_C2%PID_HNF3B_PATHWAY PID_HNF3B_PATHWAY Aldob Ucp2 Foxa2 Cebpa Foxa3 Sp1 Alb Pklr Abcc8 Cpt1b Foxa1 Dlk1 Cpt1c Kcnj11 Creb1 Bdh1 Nkx2-1 Nf1 Slc2a2 Acadm Afp Hnf1b Akt1 Cpt1a Ins2 Pck1 Tat Tfrc Hmgcs1 Hnf1a G6pc Ttr Acadvl Hnf4a F2 Igfbp1 Hadh HALLMARK_APICAL_SURFACE%MSIGDB_C2%HALLMARK_APICAL_SURFACE HALLMARK_APICAL_SURFACE Gata3 Tmem8b Brca1 Il2rg Atp6v0a4 Slc34a3 Rhcg Dcbld2 Atp8b1 Gstm5 Shroom2 Akap7 Sulf2 Slc2a4 Ncoa6 Lypd3 Ntng1 App Flot2 Cx3cl1 Hspb1 Scube1 Thy1 Lyn Srpx B4galt1 Cd160 Afap1l2 Ghrl Mal Pcsk9 Adipor2 Rtn4rl1 Crocc PID_TCR_JNK_PATHWAY%MSIGDB_C2%PID_TCR_JNK_PATHWAY PID_TCR_JNK_PATHWAY Map2k4 Prkcb LOC100911248 Jun Crkl Map3k7 Crk Map3k8 Lcp2 Mapk8 Dbnl Map4k1 Map3k1 LOC100912399 Lat BIOCARTA_ARENRF2_PATHWAY%MSIGDB_C2%BIOCARTA_ARENRF2_PATHWAY BIOCARTA_ARENRF2_PATHWAY Mapk14 Prkcb Fos Jun Keap1 Mapk1 Maff Mapk8 Creb1 Mafg Mafk Fxyd2 Prkca PID_IL12_STAT4_PATHWAY%MSIGDB_C2%PID_IL12_STAT4_PATHWAY PID_IL12_STAT4_PATHWAY Tbx21 RT1-Db1 Cd28 Cd4 Il13 Fos RT1-Da Stat1 Stat3 Tgfb1 Ppp3ca Pias2 Mapk9 Ppp3cb Cd80 Jun Irf1 Mapk8 Il2 Etv5 Cd3g Crebbp Ppp3r1 Il2ra Cd86 Ifng Cd247 Il18r1 Cd3d Il18 Cd3e HALLMARK_ANGIOGENESIS%MSIGDB_C2%HALLMARK_ANGIOGENESIS HALLMARK_ANGIOGENESIS Spp1 S100a4 Pdgfa Vegfa Prg2 Col5a2 Nrp1 Col3a1 Lrpap1 Timp1 Jag1 Olr1 Ptk2 App Pglyrp1 Thbd Stc1 Kcnj8 Fgfr1 Cxcl6 Lum Tnfrsf21 Vav2 Pf4 Postn Vcan Apoh Lpl Slco2a1 Msx1 Fstl1 Serpina5 Vtn PID_S1P_S1P1_PATHWAY%MSIGDB_C2%PID_S1P_S1P1_PATHWAY PID_S1P_S1P1_PATHWAY Gnai1 Pdgfb Ptgs2 S1pr1 Rac1 Mapk1 Plcb2 Sphk1 LOC688708 Vegfa Gnai3 Gnao1 Gnai2 Pdgfrb Gnaz Plcg1 Rhoa PID_NCADHERIN_PATHWAY%MSIGDB_C2%PID_NCADHERIN_PATHWAY PID_NCADHERIN_PATHWAY Camk2g Kif5b Gap43 Fer Plcg1 Cdh2 Lrp5 Rhoa Daglb Gsn Dagla Mapre1 Ptpn11 Cnr1 Pik3r1 Fgfr1 Gja1 Jup Ptpn1 Cttn Ctnna1 Rac1 Dctn1 Pip5k1c Mapk8 Ctnnd1 Rock1 PID_P73PATHWAY%MSIGDB_C2%PID_P73PATHWAY PID_P73PATHWAY Clca2 Serpine1 Aen Mapk14 Tp63 Sp1 Tp73 Cdkn1a Hey2 Ccne2 Gdf15 Ppap2a Afp Cdk2 Rb1 Plk1 Pml Bak1 LOC100909750 Brca2 Bcl2l11 Il1rap Abl1 Cdk1 Rela Hsf1 Serpina1 Rad51 Gata1 Dedd Hagh Ube4b Mapk11 Nsg1 Il4r Bax LOC100911267 Rnf43 Jak1 Dcp1b Pfdn5 Myc Prkacb Stt3a Mdm2 Plk3 Fas Bin1 Gramd4 Pea15 Ntrk1 Sfn Ada Cdk6 LOC100911167 Bub1 Flot2 Rchy1 Pin1 Casp2 LOC364561 Foxo3 Wt1 Ccna2 Kat5 Ndufs2 BIOCARTA_ALK_PATHWAY%MSIGDB_C2%BIOCARTA_ALK_PATHWAY BIOCARTA_ALK_PATHWAY Bmpr2 Bmp7 Chrd Smad6 Mef2c Wnt1 Apc Smad5 Fzd1 Atf2 Smad1 Bmp4 Gsk3b Bmp2 Nog Dvl1 Nppa Nkx2-5 Tgfb1 Map3k7 Hnf1a Gata4 Acvr1 Tgfb3 Tgfb2 Tgfbr2 Tgfbr1 Rfc1 Tgfbr3 BIOCARTA_TOB1_PATHWAY%MSIGDB_C2%BIOCARTA_TOB1_PATHWAY BIOCARTA_TOB1_PATHWAY Il4 Tob1 Smad3 Cd28 Tgfb3 Il2 Tgfb2 Cd3g Tgfbr2 Il2ra Tgfbr1 Ifng Tgfbr3 Cd247 Tob2 Cd3d Tgfb1 Cd3e PID_AMB2_NEUTROPHILS_PATHWAY%MSIGDB_C2%PID_AMB2_NEUTROPHILS_PATHWAY PID_AMB2_NEUTROPHILS_PATHWAY Il6 Itgam Plat Mst1 Plau Tln1 Apob Nfkb1 Rhoa Prkcz Mst1r Lck Akt1 Lrp1 Mmp9 Fgr Hck Fyn Blk Thy1 Ager Yes1 Mmp2 Src Lyn Rap1b Rap1a Jam3 Ctgf Rock1 Selplg Itgb2 Icam1 Plg Selp BIOCARTA_GCR_PATHWAY%MSIGDB_C2%BIOCARTA_GCR_PATHWAY BIOCARTA_GCR_PATHWAY Pik3r1 Adrb2 Pik3cg Gngt1 Anxa1 Rela Gnb1 LOC103692716 Nfkb1 Corin Nppa Nos3 Akt1 PID_FOXO_PATHWAY%MSIGDB_C2%PID_FOXO_PATHWAY PID_FOXO_PATHWAY Mst1 Foxo1 Ran Cdkn1b Sod2 Ywhae Sfn Mapk10 Rala Xpo1 Foxo4 Akt1 Skp2 Sgk1 Cdk2 Plk1 Ywhab Mapk9 Csnk1a1 Bcl2l11 Ralb Ywhah Cat G6pc Ywhag Gadd45a Usp7 Foxo3 Csnk1d Ikbkb Mapk8 Ywhaz Csnk1g1 Faslg Crebbp Csnk1g2 Bcl6 Fbxo32 Chuk Zfand5 Rbl2 Csnk1g3 Csnk1e PID_ATR_PATHWAY%MSIGDB_C2%PID_ATR_PATHWAY PID_ATR_PATHWAY Rad51 Rpa1 Rad1 Fancd2 LOC100911267 Rad17 Mcm7 Stt3a Mdm2 Rfc5 Rfc3 Rfc4 Rfc2 Cdc25c Rpa2 Atrip Hus1 Cdk2 Atr Plk1 Ywhab Brca2 Fbxw11 Ppp2ca Ppp2r1a Clspn Mcm2 Cep164 Smarcal1 Timeless Ccna2 Ywhaz Cdc6 Nbn Cdc25a Sspo Topbp1 PID_MYC_ACTIV_PATHWAY%MSIGDB_C2%PID_MYC_ACTIV_PATHWAY PID_MYC_ACTIV_PATHWAY Gpam Cad Ddx18 Ruvbl1 Mtdh Hspa4 Polr3d Snai1 Lin28b Ireb2 Actl6a Slc2a1 Ubtf Nme2 Myct1 Pdcd10 LOC103692716 Shmt1 Eno1 Bmi1 Taf9 Supt7l LOC680559 Mmp9 Serpini1 LOC100911431 Eif4g1 Max E2f3 Hspd1 Cdk4 Crebbp Mta1 Kat2a Fosl1 Hmga1 Eif4a1 Bax Eif2s1 Myc Tp53 Pim1 Tert Prdx3 Ruvbl2 Npm1 Smad3 Tfrc Bcat1 Nme1 Kat5 Nbn Cdc25a Id2 Rpl11 Odc1 PID_FGF_PATHWAY%MSIGDB_C2%PID_FGF_PATHWAY PID_FGF_PATHWAY Il17rd Plau Fgf6 Gab1 Fgfr4 Fgf8 Fgfr2 Sdc2 Fgf1 Camk2a Fgf9 Plcg1 Akt1 Mmp9 Fgfr1 Mapk1 Ncam1 Runx2 Fgf2 Rps6ka1 Ssh1 Hgf Spp1 Fgf23 Fgfr3 Fos Pdpk1 Sos1 Stat5b Pak4 Fgf17 Shc1 Fgf19 Cdh2 Ptk2b Stat1 Ptpn11 Bglap Pik3r1 Spry2 Cttn Jun Grb2 Cbl Fgf4 Cdh1 Frs2 Ctnnd1 Src BIOCARTA_AKAPCENTROSOME_PATHWAY%MSIGDB_C2%BIOCARTA_AKAPCENTROSOME_PATHWAY BIOCARTA_AKAPCENTROSOME_PATHWAY Map2 Ppp1ca Akap9 Nup85 Prkar2b Cdk1 Prkar2a Ppp2ca Prkacb Rhoa Pkn1 HALLMARK_KRAS_SIGNALING_UP%MSIGDB_C2%HALLMARK_KRAS_SIGNALING_UP HALLMARK_KRAS_SIGNALING_UP Igfbp3 Satb1 Hsd11b1 Gadd45g Hbegf Prkg2 Reln Nrp1 Ankh Arg1 Flt4 Btc Rbp4 Dusp6 Etv1 Spon1 Ptgs2 Ccl20 Igf2 Retn Ppbp Ppp1r15a Cxcl10 Itgb2 Bpgm Sema3b Inhba Akap12 Adam17 Cfh Il2rg Mpzl2 Angptl4 Ngf Pcp4 Tspan13 Abcb1a Nr0b2 Car2 Gypc Lif Jup Il10ra Tfpi Cbr4 Wdr33 Tph1 Cbl Mmp10 Mmp11 Adamdec1 G0s2 Mtmr10 Gpnmb Gfpt2 Ush1c Epb41l3 Trib1 Trib2 Etv4 Prrx1 Ero1l Anxa10 Plau Ace3 Gng11 Dcbld2 Fuca1 Ace Ptprr Yrdc Plvap Rabgap1l Atg10 Mafb Scn1b C2 Tmem100 Rbm4b Lat2 Nin Fbxo4 Fgf9 Bmp2 Usp12 C3ar1 Cd37 Rgs16 Btbd3 Il33 Nr1h4 Laptm5 Ephb2 Psmb8 Tspan1 Ptcd2 Dnmbp Akt2 Kif5c Ptbp2 LOC100911256 Mmd Mmp9 Sdccag8 F13a1 F2rl1 Tmem158 Tor1aip2 Plek2 Pdcd1lg2 Gprc5b Clec4a Mall Hist3h2ba Adam8 St6gal1 Pigr Lcp1 Ccser2 Strn LOC299282 Adgrl4 Cab39l Cxcr4 Tmem176a Emp1 Rbm4 Cbx8 Il1rl2 Tmem176b Galnt3 Itgbl1 Ano1 Prdm1 Kcnn4 Scg5 Sparcl1 Ets1 Spp1 Il1b Plat Crot Tnnt2 Birc3 Csf2 Snap91 Cmklr1 Wnt7a Tnfrsf1b Map4k1 Irf8 Map3k1 Vwa5a LOC100912399 Scg3 Apod Spry2 Ereg Klf4 Gucy1a3 Etv5 Glrx Pcsk1n Id2 Aldh1a3 LOC100911286 Map7 BIOCARTA_NDKDYNAMIN_PATHWAY%MSIGDB_C2%BIOCARTA_NDKDYNAMIN_PATHWAY BIOCARTA_NDKDYNAMIN_PATHWAY LOC100909679 Epn1 Dnm1 Ppp3cb Amph Bin1 Nme1 Synj2 Picalm Synj1 Nme2 Ap2m1 LOC100910792 Ppp3ca Ap2a1 HALLMARK_UV_RESPONSE_UP%MSIGDB_C2%HALLMARK_UV_RESPONSE_UP HALLMARK_UV_RESPONSE_UP Grina LOC100912455 Nptx2 Polr2h Tyro3 Ptprd RT1-M5 Atf3 RGD1565904 Cyp1a1 Cyb5b Nupl1 C4bpb Bsg Eif2s3 Pdap1 Cck Fen1 Cdc5l Atp6v1f Asns Rrad Nptxr Dnaja1 Atp6v1c1 Clcn2 Rxrb Ppat Dnajb1 Eif5 Chka Ykt6 Ggh Hspa13 Tuba4a Bak1 Nat2 LOC100912534 Apom Prpf3 Mark2 Htr7 Sigmar1 Tgfbrap1 Creg1 Psmc3 Klhdc3 Irf1 Cyb5r1 Epcam Plcl1 Ago2 Onecut1 Stard3 Rpn1 Il6st Lhx2 Stip1 Maoa Polg2 Mgat1 Sqstm1 Chrna5 Icam1 Spr Nxf1 Hnrnpu Ppt1 Wiz Ap2s1 Cdkn2b Mapk8ip2 Furin Abcb1a Car2 Tars Cxcl1 Aqp3 H2afx Msx1 Hmox1 Junb Hyal2 Arrb2 Lyn Ntrk3 Mmp14 Btg2 Ctsl Rasgrp1 Tap1 Tacr3 Grpel1 Aldoa Sult1a1 Pdlim3 Fkbp4 Bmp2 Rfc4 Ppif Sod2 Ccne1 Eno2 Dgat1 E2f5 Olfm1 Cdk2 Cnp Amd1 Igfbp2 Prkcd Bcl2l11 Tst Slc25a4 Nfkbia Cebpg Dlg4 LOC100911625 Ccnd3 Gal Ret Btg3 Kcnh2 Gch1 Gpx3 Bid Casp3 Stk25 Il6 Prkaca Fos Rab27a Hspa2 Rhob Ddx21 Ephx1 Nkx2-5 Mrpl23 Tfrc Parp2 Urod Btg1 Cdo1 Slc6a12 Cltb Nr4a1 Fmo1 ST_PAC1_RECEPTOR_PATHWAY%MSIGDB_C2%ST_PAC1_RECEPTOR_PATHWAY ST_PAC1_RECEPTOR_PATHWAY Gast Itpka Asah1 Itpkb Camp Gnaq Dag1 BIOCARTA_EXTRINSIC_PATHWAY%MSIGDB_C2%BIOCARTA_EXTRINSIC_PATHWAY BIOCARTA_EXTRINSIC_PATHWAY F3 Serpinc1 Proc F2r F7 Tfpi Pros1 Fga F2 Fgg Fgb F10 PID_INTEGRIN_CS_PATHWAY%MSIGDB_C2%PID_INTEGRIN_CS_PATHWAY PID_INTEGRIN_CS_PATHWAY Itgax Itga4 Itga11 Itga8 Itgam Itga7 Itga10 Itga6 Itgb1 Itgb4 Itga3 Itgb7 Itga5 Itgb6 Itgb2 Itgb8 Itgal Itga2b BIOCARTA_SPRY_PATHWAY%MSIGDB_C2%BIOCARTA_SPRY_PATHWAY BIOCARTA_SPRY_PATHWAY Spry2 Hras Raf1 Map2k1 Mapk1 Grb2 Sos1 Cbl Src Spry1 Shc1 Rasa1 Egfr Spry4 PID_SHP2_PATHWAY%MSIGDB_C2%PID_SHP2_PATHWAY PID_SHP2_PATHWAY Pdgfb Ntf4 Gab1 Ntrk2 Sdc2 Ntf3 Vegfa Rhoa Nos3 Gnai1 Igf1r Igf1 Raf1 Ifngr1 Irs1 Nras Angpt1 Lmo4 Pdgfrb Il6st Tek Il6 Hras Jak3 Jak1 Il2rg Prkaca Gab2 Map2k1 Sos1 Map2k2 Ntrk1 Ngf Shc1 Bdnf Kras Arhgap35 Stat1 Egfr Ptpn11 Lck Pik3r1 Grb2 Il2 Frs2 Gnai3 Frs3 Ntrk3 Il2ra Ifng HALLMARK_PANCREAS_BETA_CELLS%MSIGDB_C2%HALLMARK_PANCREAS_BETA_CELLS HALLMARK_PANCREAS_BETA_CELLS Pcsk1 Foxa2 Iapp Pcsk2 Chga Sst Gcg Isl1 Srp14 Foxo1 Abcc8 Pklr Mafb Pak3 Dpp4 Pax4 Vdr Neurod1 Nkx6-1 Syt13 Pax6 Stxbp1 Slc2a2 Scgn Dcx Akt3 Nkx2-2 Lmo2 Ins2 Sec11a Srp9 Hnf1a Neurog3 BIOCARTA_IGF1MTOR_PATHWAY%MSIGDB_C2%BIOCARTA_IGF1MTOR_PATHWAY BIOCARTA_IGF1MTOR_PATHWAY Mtor Pik3r1 Igf1r Eif4ebp1 LOC100911372 Eif2s1 Igf1 Pten Ppp2ca Eif2s3 Pdpk1 Eif2s2 Eif2b5 Rps6kb1 Pdk2 Rps6 Gsk3b Akt1 BIOCARTA_ERK5_PATHWAY%MSIGDB_C2%BIOCARTA_ERK5_PATHWAY BIOCARTA_ERK5_PATHWAY Pik3r1 Hras Mef2d Pik3cg Mapk1 Grb2 Ntrk1 Mef2c Shc1 Creb1 Plcg1 Rps6ka1 Akt1 PID_AP1_PATHWAY%MSIGDB_C2%PID_AP1_PATHWAY PID_AP1_PATHWAY Atf3 Plau Sp1 Cdkn1b Creb1 Penk Tgfb1 Th Mt2A Mmp9 Maf Bcl2l11 Pten Bag1 Cdkn2a Cdk1 Dmp1 Fabp4 Fosl1 Il4 Il5 Il6 Il10 Ets1 Myc Tp53 Fos Ccnd1 Elf1 Nts Edn1 Csf2 Dusp1 Ccl12 Esr1 Agt Atf2 Col1a2 Nfatc2 Timp1 Nfatc3 Nppa Mmp1 Cbfb Gja1 Egr1 Acta1 Jun Hif1a Cyr61 Dmtf1 Jund Junb Il2 Mafg Ifng Gata2 BIOCARTA_MTOR_PATHWAY%MSIGDB_C2%BIOCARTA_MTOR_PATHWAY BIOCARTA_MTOR_PATHWAY Mtor LOC680559 Eif3a Pik3r1 Eif4ebp1 LOC100911431 LOC100911372 Eif4g2 Eif4g1 Pten Ppp2ca Pdpk1 Mknk1 Fkbp1a Rps6kb1 Pdk2 Eif4a2 Rps6 Tsc1 Tsc2 Eif4g3 Eif4b Akt1 Eif4a1 PID_ERBB4_PATHWAY%MSIGDB_C2%PID_ERBB4_PATHWAY PID_ERBB4_PATHWAY Pik3cb Cbfa2t3 Adam17 Grin2b Mdm2 Hbegf Stat5b Nrg1 Erbb4 Shc1 Stat5a Lrig1 Btc Erbb2 Pik3r2 Pik3r1 Pik3r3 Ereg Prl Nrg3 Wwp1 Fyn Pik3cd Nrg4 Mapk1 Grb2 Dlg4 Tab2 Nrg2 BIOCARTA_EGF_PATHWAY%MSIGDB_C2%BIOCARTA_EGF_PATHWAY BIOCARTA_EGF_PATHWAY Stat2 Stat6 Hras Jak1 Fos Map2k1 Sos1 Srf Stat5b Shc1 Rasa1 Stat5a Map3k1 LOC100912399 Plcg1 Egfr Stat1 Elk1 Stat3 Csnk2a1 Pik3r1 Map2k4 Prkcb Jun Raf1 Grb2 Mapk8 Prkca PID_FOXM1_PATHWAY%MSIGDB_C2%PID_FOXM1_PATHWAY PID_FOXM1_PATHWAY Myc Cenpa Foxm1 Fos Ccnd1 Sp1 Map2k1 Esr1 Gsk3a Cks1b Ccne1 Nfatc3 Cks1l Tgfa Skp2 Cdk2 Rb1 Plk1 Xrcc1 Brca2 Aurkb Chek2 Cdk4 Lama4 Etv5 Ccna2 Mmp2 Crebbp Onecut1 Cdkn2a Cdc25b Cdk1 Cenpf PID_BARD1_PATHWAY%MSIGDB_C2%PID_BARD1_PATHWAY PID_BARD1_PATHWAY Rad51 Rad50 LOC100911267 Fancd2 Ewsr1 Fancc Brca1 Tp53 LOC100912481 Rbbp8 Ube2d3 Fance Bard1 Ccne1 Fancl Fanca Mre11a Fancf Npm1 Atr Cdk2 Ube2l3 Xrcc6 Xrcc5 Prkdc Pcna Atm Nbn Cstf1 Topbp1 PID_AVB3_INTEGRIN_PATHWAY%MSIGDB_C2%PID_AVB3_INTEGRIN_PATHWAY PID_AVB3_INTEGRIN_PATHWAY Vav3 Col4a3 Col6a1 Col4a1 Casp8 Cdkn1b Col11a2 Vegfa Col4a5 Col5a1 LOC100911572 LOC103692716 Rhoa Akt1 Igf1r Igf1 Rac1 Mapk1 Irs1 Rps6kb1 Col14a1 Bcar1 Col13a1 Tgfbr2 Fgf2 Rock1 Fn1 Angptl3 Vtn Col17a1 Csf1 Csf1r Pxn Spp1 Mfge8 F11r Tln1 Col1a1 Col9a1 Col5a2 Col1a2 Col9a2 Col3a1 Col8a1 Ptk2b Col8a2 Ptpn11 Col6a2 Ptk2 Pik3r1 Col11a1 Col16a1 Cbl Pik3c2a Pi4kb Src Vcl Ilk BIOCARTA_CARM1_PATHWAY%MSIGDB_C2%BIOCARTA_CARM1_PATHWAY BIOCARTA_CARM1_PATHWAY Rxra Creb1 Crebbp Prkar1b Prkar2b Prkar2a Carm1 Prkacb Rara HALLMARK_TNFA_SIGNALING_VIA_NFKB%MSIGDB_C2%HALLMARK_TNFA_SIGNALING_VIA_NFKB HALLMARK_TNFA_SIGNALING_VIA_NFKB Ccl5 Ccl4 Ripk2 Atf3 Kynu Il23a Irs2 Pdlim5 Socs3 Pnrc1 Hbegf Vegfa Jag1 Gadd45b Sgk1 Tlr2 Atp2b1 Ldlr Dusp4 Ptgs2 Cxcl3 Ccl20 Nfil3 Nfat5 Cxcl2 Ifngr2 Hes1 Gadd45a Irf1 Ppp1r15a Il6st Cd44 Tnip2 Cxcl10 Cxcl11 Sqstm1 Icam1 Il1a Ninj1 Csf1 Inhba Serpinb8 Plek Myc Ccnd1 Klf6 Sphk1 Dusp1 Dusp2 Egr2 Egr3 Ptpre Olr1 Cxcl1 Smad3 Lif Dusp5 Cxcl6 Egr1 Efna1 Abca1 Cd83 Junb Clcf1 Btg2 G0s2 Mxd1 Ptger4 Nr4a2 Spsb1 Phlda1 Rnf19b Tubb2a Fjx1 Tap1 Serpine1 Gfpt2 Ehd1 Zc3h12a Bhlhe40 Litaf Trib1 Eif1 Cflar Gpr183 Sik1 Msc Plau Dnajb4 Sdc4 B4galt5 Tgif1 Yrdc Ccrl2 Cdkn1a Kdm6b Tnfrsf9 Gm5471 Plk2 Klf2 Bmp2 Bcl2a1 Klf9 Sod2 Fut4 Per1 Ccnl1 Nfkb2 Panx1 Nfkb1 Slc16a6 Tnip1 Dennd5a Phlda2 Serpinb2 Nfe2l2 Ppap2b Slc2a6 Klf10 Nr4a3 F2rl1 Icoslg Ptx3 Slc2a3 Ifit2 Nfkbia Nfkbie Map3k8 Maff Tank F3 Ifih1 Ackr3 Bcl6 Snn Rela Btg3 Gch1 Fosl1 Lamb3 Il6 Il1b Fos Birc3 Ets2 Edn1 Csf2 Ccl12 Stat5a Rhob Birc2 Tnfaip8 Tiparp Cd80 Tnfaip2 Jun Cd69 Pmepa1 Cyr61 Btg1 Tsc22d1 Zbtb10 Nampt Pfkfb3 Klf4 Ier3 B4galt1 Nr4a1 Areg Id2 Sat1 Il12b Il18 PID_PS1_PATHWAY%MSIGDB_C2%PID_PS1_PATHWAY PID_PS1_PATHWAY Notch1 Psenen Psen1 Myc Fos Ccnd1 Hdac1l Wnt1 Apc Lrp6 Fzd1 Gsk3b Dvl1 Ctbp1 Hdac1 Nlk Csnk2a1 Csnk1a1 Tle1 Fbxw11 Jun Map3k7 Ppard Hnf1a Ncstn Mapk1 Nkd1 Wif1 LOC100911293 Aes Kremen2 Aph1b Dkk2 Crebbp Dkk1 Sspo PID_INTEGRIN4_PATHWAY%MSIGDB_C2%PID_INTEGRIN4_PATHWAY PID_INTEGRIN4_PATHWAY Lama1 Lamc1 Lamb3 Lamc2 Lamb2 Itga6 Itgb4 Lamb1 BIOCARTA_THELPER_PATHWAY%MSIGDB_C2%BIOCARTA_THELPER_PATHWAY BIOCARTA_THELPER_PATHWAY Cd3g Cd28 Cd4 Cd2 Itgb2 Icam1 Cd247 Thy1 Itgal Cd3d Ptprc Cd3e ST_WNT_CA2_CYCLIC_GMP_PATHWAY%MSIGDB_C2%ST_WNT_CA2_CYCLIC_GMP_PATHWAY ST_WNT_CA2_CYCLIC_GMP_PATHWAY Pde6d Pde6c Tf Pde6h Camk2d Dag1 Camk2g Nfat5 C2 Pde6b Itpr1 Camk2a Itpka Itpr3 Slc6a13 Itpkb Pde6a PID_HDAC_CLASSIII_PATHWAY%MSIGDB_C2%PID_HDAC_CLASSIII_PATHWAY PID_HDAC_CLASSIII_PATHWAY Tubb2a Ppargc1a Bax Myod1 Mef2d Foxo1 Xrcc6 Sirt2 Tp53 Fhl2 Cdkn1a Foxo3 Crebbp Sirt3 Acss2 Hoxa11 LOC100909443 Foxo4 Hdac4 Acss1 PID_INTEGRIN3_PATHWAY%MSIGDB_C2%PID_INTEGRIN3_PATHWAY PID_INTEGRIN3_PATHWAY Spp1 F11r Pdgfb Plau Sdc4 Col4a3 Sphk1 Col4a1 Col1a1 Vegfa Col4a5 LOC100911572 Col1a2 Fga Fgg Fgb Itga2b Cyr61 Thy1 Fbn1 Lama4 Lamc1 Cd47 L1cam Pdgfrb Tgfbr2 Fn1 Vtn Lamb1 Ibsp HALLMARK_PI3K_AKT_MTOR_SIGNALING%MSIGDB_C2%HALLMARK_PI3K_AKT_MTOR_SIGNALING HALLMARK_PI3K_AKT_MTOR_SIGNALING Fgf22 Cdkn1b Slc2a1 Mapkap1 Ecsit Atf1 Ywhab Pten Map3k7 Raf1 Ralb Rac1 Mapk1 E2f1 Smad2 Cdk4 Ppp1ca Cdk1 Rps6ka1 Sqstm1 Trib3 Tsc2 Akt1s1 Myd88 Il2rg Cfl1 Ngf Calr Prkar2a Hsp90b1 Lck Actr3 Csnk2b Rit1 Prkcb Prkaa2 Plcb1 Pin1 LOC364561 Arpc3 Gna14 Tiam1 Actr2 Faslg Ripk1 Ddit3 Vav3 Fgf6 Camk4 Cdkn1a Pfn1 Gsk3b Dapp1 Ube2n Plcg1 Rps6ka3 Pdk1 Mapk10 Akt1 Cdk2 Dusp3 Them4 Cab39 Pla2g12a Ppp2r1b Mknk2 Pikfyve Pitx2 Mknk1 Tbk1 Nfkbib Adrbk1 Mapk8 Gngt1 Traf2 Cab39l Cxcr4 Irak4 Il4 Stat2 Hras Nod1 Rptor Ube2d3 Pak4 Fgf17 Sfn Egfr Ptpn11 Nck1 Arhgdia Pik3r3 Mapk9 Grb2 Tnfrsf1a Map2k6 Ap2m1 Cltc BIOCARTA_RAS_PATHWAY%MSIGDB_C2%BIOCARTA_RAS_PATHWAY BIOCARTA_RAS_PATHWAY Casp9 Pik3r1 Hras Pik3cg Raf1 Rac1 Ralgds Map2k1 Ralbp1 Pld1 Rela Chuk Nfkb1 Rhoa Rala Bad Bcl2l1 Elk1 Foxo4 Akt1 PID_CDC42_PATHWAY%MSIGDB_C2%PID_CDC42_PATHWAY PID_CDC42_PATHWAY Mapk14 Apc Gsk3b Pld1 F2rl2 Prkcz Raf1 Rac1 Mapk1 Yes1 Arhgef6 Rps6kb1 Mapk8 Arhgef7 Bcar1 Mtor Hras Eps8 Cfl1 Limk2 Pak4 Atf2 Map3k1 LOC100912399 Tnk2 Pax6 Pak1 Cdc42bpa Sept2 Hes5 Actr3 Arpc4 Arpc5 Iqgap1 Pik3r1 Arhgdia Map2k4 Pak2 Mapk9 Limk1 Vav2 Pard6a Iqgap3 Ctnna1 Jun Map3k11 Enah Map2k7 Dlg1 Arpc3 Arpc2 Tiam1 Arpc1b Cbl Actr2 Baiap2 Cdh1 Map2k6 Src Exoc7 BIOCARTA_CALCINEURIN_PATHWAY%MSIGDB_C2%BIOCARTA_CALCINEURIN_PATHWAY BIOCARTA_CALCINEURIN_PATHWAY Prkcb Ppp3cb Nfatc2 Gnaq Prkca Plcg1 Nfatc4 Sp1 Nfatc3 Cdkn1a Ppp3ca HALLMARK_DNA_REPAIR%MSIGDB_C2%HALLMARK_DNA_REPAIR HALLMARK_DNA_REPAIR Polr2h RGD1565904 Ssrp1 Fen1 Poll Adrm1 Taf9 Tarbp2 Dad1 Mrpl40 Nme3 Xpc Dgcr8 LOC100912534 Gtf2h5 Gtf2h3 Ccno Adcy6 Npr2 LOC100909857 Polh Polr1c Mpg Polb Dguok Pcna Impdh2 Nudt21 Rev3l LOC100911822 Sf3a3 Rpa3 Tmed2 Rae1 Tceb3 Polr3gl Ak3 Taf13 Ercc8 Ercc5 Guk1 Lig1 Rad51 LOC100911267 Rbx1 Tp53 Cant1 Smad5 Ercc1 Ercc3 Umps Gtf2f1 Gtf3c5 Nme1 Usp11 Tyms Hcls1 Rfc5 Rfc3 Rfc4 Rfc2 Rpa2 Cmpk2 Pola2 Edf1 Tk2 Bcap31 Pnp Upf3b Gtf2h1 Gmpr2 Ago4 Sdcbp Nudt9 Itpa Alyref Dctn4 Pom121 Pole4 Snapc4 Srsf6 Snapc5 Vps37b Aprt Rrm2b Arl6ip1 Nt5c3a Ddb1 Stx3 Clp1 Polr2g Polr2f Supt5h Polr2e Rala Ada Tsg101 Taf6 Polr2a Vps28 Ell Rnmt Nfx1 Polr2c Polr2d Bcam Nelfb Polr2i Polr2j Gtf2b Rad52 Pold4 Sec61a1 Eif1b Taf1c Supt4h1 Decr2 LOC100912008 Nelfe Znrd1 Cda Polr3c Cox17 Brf2 Pold1 Gpx4 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY%MSIGDB_C2%ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY Foxo1 Cyth3 Sos1 Cd55 Shc1 Ppp1r13b Gsk3b Gsk3a Dapp1 Ywhae Sfn Pdk1 Rps6ka3 Akt2 Bad Akt3 Inpp5d Akt1 Rps6ka2 Ywhab Nr4a3 Pten Ywhah Grb2 Ywhag Rps6kb1 A1bg Ywhaz Cdkn2a Iars Rps6ka1 Igfbp1 BIOCARTA_VEGF_PATHWAY%MSIGDB_C2%BIOCARTA_VEGF_PATHWAY BIOCARTA_VEGF_PATHWAY Eif2b4 Pxn Eif1ax Hras Eif1 Eif2s1 Vhl Eif2s3 Eif2s2 Eif2b5 Gm5471 Vegfa Shc1 Flt1 Plcg1 Flt4 Nos3 Ptk2 LOC100911280 Pik3r1 Prkcb Pik3cg Hif1a Arnt Prkca Eif2b2 Eif2b3 Elavl1 Eif2b1 BIOCARTA_TPO_PATHWAY%MSIGDB_C2%BIOCARTA_TPO_PATHWAY BIOCARTA_TPO_PATHWAY Csnk2a1 Pik3r1 Mpl Hras Prkcb Pik3cg Raf1 Jun Fos Grb2 Map2k1 Sos1 Thpo Stat5b Shc1 Rasa1 Stat5a Prkca Plcg1 Stat1 Stat3 BIOCARTA_CDC42RAC_PATHWAY%MSIGDB_C2%BIOCARTA_CDC42RAC_PATHWAY BIOCARTA_CDC42RAC_PATHWAY Actr3 Arpc4 Arpc5 Pik3r1 Pdgfra Pak1 Rhoa Arpc3 Rac1 Arpc2 Arpc1b Actr2 BIOCARTA_MTA3_PATHWAY%MSIGDB_C2%BIOCARTA_MTA3_PATHWAY BIOCARTA_MTA3_PATHWAY Tuba4a Hspb1 Aldoa Tuba3a Pdzk1 Mbd3 Tuba3b Hdac1l Cdh1 Esr1 Snai1 Mta1 Ctsd Hdac1 Hspb2 BIOCARTA_ARF_PATHWAY%MSIGDB_C2%BIOCARTA_ARF_PATHWAY BIOCARTA_ARF_PATHWAY Pik3r1 Rb1 LOC100909750 Polr1b Pik3cg Tbx2 Myc Tp53 Polr1a Twist1 Rac1 Polr1c Mdm2 E2f1 Abl1 Cdkn2a BIOCARTA_EIF_PATHWAY%MSIGDB_C2%BIOCARTA_EIF_PATHWAY BIOCARTA_EIF_PATHWAY LOC680559 Eif3a Eif1ax LOC100911431 Eif2s1 Eif1 Eif4g2 Eif4g1 Eif2s3 Eif6 Eif2s2 Gm5471 Eif4a2 Eef2k Eef2 Eif4g3 Eif5 Eif4a1 PID_PI3KCI_AKT_PATHWAY%MSIGDB_C2%PID_PI3KCI_AKT_PATHWAY PID_PI3KCI_AKT_PATHWAY Mtor Casp9 Rictor Foxo1 Prkaca Pdpk1 Kpna1 Cdkn1a Cdkn1b Gsk3b Gsk3a Slc2a4 Ywhae Sfn LOC103692716 Akt2 Bad Akt3 Foxo4 Akt1 Mapkap1 Ywhab Raf1 Ywhah Prkdc Ywhag Foxo3 Ywhaz Src Chuk Mlst8 Bcl2l1 PID_P53_DOWNSTREAM_PATHWAY%MSIGDB_C2%PID_P53_DOWNSTREAM_PATHWAY PID_P53_DOWNSTREAM_PATHWAY Igfbp3 Pidd1 Atf3 Tp63 Smarca4 Perp Hdac2 Foxa1 Tp53inp1 Vdr Bdkrb2 Gdf15 Tgfa Taf9 LOC100911519 Bak1 Dgcr8 E2f3 Pten E2f1 Pcna Gadd45a Pou4f2 Mmp2 Gpx1 Col18a1 Cd82 Tsc2 Ctsd Tp53 Pms2 Mdm2 Plk3 Dusp1 Prkab1 Rchy1 Cx3cl1 Dusp5 Lif Ccng1 Serpinb5 Epha2 Btg2 Cse1l Serpine1 Tap1 Sp1 Tp73 Cdkn1a Apc Fdxr Bcl2a1 Rnf144b Carm1 Afp Rb1 Pml Htt Tada2b Prmt1 Sesn1 Ccnk Ppm1j LOC502894 Msh2 Nlrc4 Tyrp1 Zfp385a Pcbp4 Crebbp Bcl2l2 Bcl2l14 Apaf1 Steap3 Bcl6 Nfyb Drosha Nfya Nfyc Kat2a Tp53bp2 Triap1 Hgf Cebpz LOC100910137 Bcl2l1 Sh2d1a Prdm1 Mlh1 Pycard Casp6 Bid Ddit4 Casp1 Spp1 Bax Bcl2 Fas Edn2 Rrm2b Ppp1r13b Sfn Egfr Jun Irf5 Vcan Bnip3l Dkk1 Ddx5 Ndrg1 BIOCARTA_RAC1_PATHWAY%MSIGDB_C2%BIOCARTA_RAC1_PATHWAY BIOCARTA_RAC1_PATHWAY Ncf2 Pik3r1 Pdgfra Limk1 Wasf1 Pik3cg Mylk Rac1 Cdk5r1 Cfl1 Ralbp1 Trio Rps6kb1 Arfip2 Cdk5 Pld1 Map3k1 LOC100912399 Pak1 Vav1 NABA_ECM_GLYCOPROTEINS%MSIGDB_C2%NABA_ECM_GLYCOPROTEINS NABA_ECM_GLYCOPROTEINS Fndc7 Igfbp3 Wisp3 Egflam Fndc8 Vwa5b1 Tecta Wisp1 Vwa5b2 Cthrc1 Sbspon Slit3 Slit1 Emid1 Dpt Papln Fndc1 Reln Colq Tinagl1 Crim1 Ltbp1 Tectb Ltbp2 Ltbp4 Vwa9 Mmrn1 Vwa7 Mmrn2 Vwa1 Dspp Spon1 Spon2 Nov LOC100911714 Postn Matn1 Matn4 Matn2 Vit Nid2 Matn3 Ctgf Sspo Nid1 Fn1 Eln Crispld1 Amelx Bglap Mgp Cilp2 Adipoq Vwf Fbln5 Srpx2 Fbln2 Igsf10 Fga Fgg Fgb Wisp2 Lama1 Igfbp2 Ppip5k1 Emilin2 Lrg1 Emilin3 Slit2 Mepe Igfbpl1 Smoc2 Nell1 Hmcn1 Nell2 Lama4 Svep1 Bmper Srpx Smoc1 Dmp1 Vtn Sparc Lgi1 Lgi3 Fbln7 Igfbp7 Lgi4 Zp1 Sparcl1 Lamb3 Lamb2 Spp1 Fbln1 Mfge8 Igfals Thbs2 Thbs4 Ntn3 Mfap3 Ntn1 Mfap2 Mfap5 Mfap4 Otol1 Ntn5 Vwa5a Igfbp5 Cilp Efemp1 Ntng1 Emilin1 Gldn Gas6 Otog Tnr Agrn Fgl2 Tsku Cyr61 Ambn Fras1 Tnn Igfbp6 Fgl1 Fbn1 Creld1 Rspo4 Lamc1 Lamc2 Rspo2 Creld2 Rspo3 Pcolce Oit3 Vwa3a Ecm1 Igfbp4 Rspo1 Igfbp1 Zp4 Aebp1 Lamb1 Zp3 Ibsp PID_RHOA_REG_PATHWAY%MSIGDB_C2%PID_RHOA_REG_PATHWAY PID_RHOA_REG_PATHWAY Arap1 Abr Srgap1 Myo9b Vav3 Mcf2l Ophn1 Trio Cdkn1b Net1 Arhgap35 Ect2 Def6 Rhoa Vav1 Arhgap9 Arhgap8 Arhgef28 Arhgef25 Arhgdia Vav2 LOC100912512 Arhgdib Arhgef3 Arhgef2 Ngef Farp1 Arhgef5 Arhgef18 Arhgap5 Arhgef11 Arhgef15 ST_JNK_MAPK_PATHWAY%MSIGDB_C2%ST_JNK_MAPK_PATHWAY ST_JNK_MAPK_PATHWAY Tp53 Gab1 Il1r1 Shc1 Atf2 Map3k1 LOC100912399 Nfatc3 Mapk10 Dld Akt1 Map3k9 Nr2c2 Map3k4 Map3k12 Dusp10 Myef2 Map2k4 Map3k13 Mapk9 Map3k10 Dusp4 Jun Map3k11 Map3k7 Map2k7 Map3k2 Tab2 Map2k5 Gadd45a Mapk8 Pappa Map3k3 Traf6 HALLMARK_GLYCOLYSIS%MSIGDB_C2%HALLMARK_GLYCOLYSIS HALLMARK_GLYCOLYSIS Igfbp3 Me1 Got2 Nsdhl P4ha2 Cenpa Irs2 Chst12 Depdc1 Vegfa Gys2 Dsc2 Ndst3 Col5a1 Cyb5a Hs6st2 Gmppb Chpf2 Fut8 LOC100911109 Cited2 Gpr87 B3gnt3 Chst1 Paxip1 Pdk3 Tgfa Chst5 Rragd Chst4 Dld Cldn9 Gfpt1 Cth Galk2 Alg1 Slc25a10 Miox Srd5a3 Lhx9 Cog2 Tpst1 Glce Rpe Gmppa Pkm Spag4 Aldh7a1 Pmm2 Slc16a3 Kif2a Arpp19 Fbp2 Got1 Pfkfb1 B4galt4 Cdk1 B4galt7 Ppia Abcb6 Cd44 B3gat1 B4galt2 Ak3 Mdh1 Chpf Sdhc Nanp Gusb Akr1a1 Mdh2 Bpnt1 Qsox1 LOC100360218 Ppp2cb Lhpp Bik Txn1 Gne Tsta3 Ldhc Egln3 Ak4 Gys1 Med24 Angptl4 Gale Pgk1 Ugp2 Hmmr Idh1 Ndufv3 Kif20a Capn5 Dcn Aurka Ang2 Aldob Agl Dpysl4 Elf3 Pam Aldoa Ero1l Sdc3 Sdc2 Fkbp4 Mif Ppfia4 Zfp292 Taldo1 Sod1 Gapdhs Eno1 Eno2 Kdelr3 Plod1 Stc1 Rars Galk1 Aldh9a1 P4ha1 Stc2 Slc37a4 Tktl1 Hspa5 Ankzf1 Plod2 LOC100911625 Lct Nt5e Stmn1 Pygl Mpi Pgam2 Cxcr4 Nol3 Vldlr Fam162a Nasp Pygb Tff3 Polr3k Me2 B3galt6 Cln6 Isg20 Xylt2 Hs2st1 Gpc4 Cldn3 Casp6 Ddit4 Cacna1h Mertk Hk2 Adora2b Egfr Rbck1 Ext1 Il13ra1 Psmc4 Pc Agrn Pgls Hdlbp Vcan Tpbg Ier3 Glrx Artn B4galt1 Pgm2 Pfkp Gclc SA_G2_AND_M_PHASES%MSIGDB_C2%SA_G2_AND_M_PHASES SA_G2_AND_M_PHASES Nek1 Cdc25b Cdk1 Cdc25a Cdk7 Stt3a Wee1 Cdkn1a PID_ERBB2_ERBB3_PATHWAY%MSIGDB_C2%PID_ERBB2_ERBB3_PATHWAY PID_ERBB2_ERBB3_PATHWAY Mtor Pik3cb Hras Prkaca Fos Map2k1 Sos1 Map2k2 Nrg1 Shc1 Chrna1 Kras Nfatc4 Mapk10 Bad Erbb2 Stat3 Ptpn11 Akt1 Pik3r2 Pik3r1 Pik3r3 Mapk9 Ppp3cb Nf2 Usp8 Jun Raf1 Pik3cd Rac1 Grb2 Mapk1 Nras Nrg2 Chrne Mapk8 Src Erbb3 Rnf41 BIOCARTA_CELL2CELL_PATHWAY%MSIGDB_C2%BIOCARTA_CELL2CELL_PATHWAY BIOCARTA_CELL2CELL_PATHWAY Actn2 Pxn Actn3 Src Bcar1 Vcl Ctnna1 Csk Actn1 Ptk2 BIOCARTA_KERATINOCYTE_PATHWAY%MSIGDB_C2%BIOCARTA_KERATINOCYTE_PATHWAY BIOCARTA_KERATINOCYTE_PATHWAY Mapk13 Ripk1 Cebpa Hras Ets1 Bcl2 Mapk14 Fos Ets2 Sp1 Map2k1 Fas Tnfrsf1b Map3k1 LOC100912399 Nfkb1 Prkch Egfr Prkcq Daxx Map2k4 Prkcb Prkcd Jun Raf1 Ppp2ca Nfkbia Map2k7 Mapk1 Tnfrsf1a Ikbkb Map2k6 Mapk8 Faslg Traf2 Rela Chuk Prkca Map3k14 PID_INTEGRIN5_PATHWAY%MSIGDB_C2%PID_INTEGRIN5_PATHWAY PID_INTEGRIN5_PATHWAY Itga4 Vcam1 Itgb6 Tgfbr1 Plau Fn1 Cyr61 Itgb8 Vtn Madcam1 Itgb7 Fbn1 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES%MSIGDB_C2%SIG_IL4RECEPTOR_IN_B_LYPHOCYTES SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Stat6 Pik3r1 Jak3 Il4r Jak1 Bcl2 Raf1 Pik3cd Irs2 Grb2 Mapk1 Sos1 Irs1 Socs1 Shc1 Ppp1r13b Map4k1 Gsk3b Gsk3a Pdk1 Akt2 Bad Akt3 Akt1 PID_NOTCH_PATHWAY%MSIGDB_C2%PID_NOTCH_PATHWAY PID_NOTCH_PATHWAY Il4 Gata3 Notch1 Psenen Psen1 Yy1 Myc Ccnd1 Rbbp8 Ptcra Mfap2 Mfap5 Cdkn1a Kdm1a Hdac1l Dlk1 Furin Jag1 Eno1 Ctbp1 Hdac1 Skp2 Dner Dll4 Skp1 Dll3 Lnx1 Cul1 Dnm1 Mark2 Cntn1 Notch4 Ncstn Cntn6 Mib1 Cbl Adam12 Neurl1 LOC100911293 Maml1 Aph1b Ncor2 Notch2 Sspo Rab11a Notch3 BIOCARTA_PLCE_PATHWAY%MSIGDB_C2%BIOCARTA_PLCE_PATHWAY BIOCARTA_PLCE_PATHWAY Rap2b Prkar1b Ptger1 Adrb2 Prkar2b Prkar2a Prkacb Plce1 PID_HIF1_TFPATHWAY%MSIGDB_C2%PID_HIF1_TFPATHWAY PID_HIF1_TFPATHWAY LOC497963 Serpine1 Bhlhe40 Aldoa Epo Sp1 Vegfa Creb1 Slc2a1 Adm Cited2 Bhlhe41 Eno1 Car9 Abcg2 Akt1 Plin2 Ncoa1 Ncoa2 Pkm Arnt Pgm1 Nt5e Crebbp Cxcr4 Itgb2 Tff3 Cxcl12 Egln3 Ets1 Fos Cp Pgk1 Edn1 Bnip3 Tert Hk2 Furin Abcb1a Npm1 Smad3 Tf Lep Tfrc Jun Fech Hif1a Hmox1 Pfkfb3 Rora Hnf4a Id2 Pfkl Igfbp1 Ndrg1 Gata2 PID_RHODOPSIN_PATHWAY%MSIGDB_C2%PID_RHODOPSIN_PATHWAY PID_RHODOPSIN_PATHWAY Gucy2f Gucy2d Lrat Rho Rgs9bp Rgs9 Rpe65 Gnb5 Guca1b Guca1a Grk1 Cngb1 Pde6b Gngt1 Gnat1 Cnga1 Pde6a Gnb1 Sag PID_MYC_REPRESS_PATHWAY%MSIGDB_C2%PID_MYC_REPRESS_PATHWAY PID_MYC_REPRESS_PATHWAY Ccl5 Fth1 Dnmt3a Ddit3 Hmgcs2 Tmeff2 Clu Cebpa Slc11a1 Brca1 Tjp2 Cflar Mxd4 Tmem126a Sp1 Cdkn1a Hdac1l Lgals1 Cdkn1b Tbp Creb1 Sfrp1 Erbb2 Hdac1 Aldh9a1 Itga6 Max Smad2 Gadd45a Ndrg2 Pdgfrb Nfyb Nfya Dntt Nfyc Tsc2 Gfi1 Cdkn2b Bcl2 Rbl1 Myc Itgb1 Ccnd1 Irf8 Col1a2 Zbtb17 Spi1 Hdac3 Smad3 Itgb4 Foxo3 Wnt5a Dkk1 Id2 Ppp2r4 Ndrg1 Gtf2h2 Sfxn3 PID_REG_GR_PATHWAY%MSIGDB_C2%PID_REG_GR_PATHWAY PID_REG_GR_PATHWAY Tbx21 Mapk14 Smarca4 Cdkn1a Hdac1l Hdac2 Krt14 Fkbp4 Tbp Creb1 Gsk3b LOC103692716 Nfkb1 Mapk10 Fgg Afp Hdac1 Akt1 Sgk1 Prl Ncoa1 Ncoa2 Ywhah Mapk1 Cdk5r1 Irf1 Mapk8 Crebbp Rela Icam1 Il4 Gata3 Il5 Mapk11 Il6 Bax Il13 Prkaca Tp53 Fos Prkacb Mdm2 Csf2 Smarcc1 Stat5b Cdk5 Stat5a Sfn Tsg101 Stat1 Spi1 Sele Bglap Mmp1 Mapk9 Egr1 Jun Krt17 Csn2 Smarcd1 Pou1f1 Ppp5c Cga Il2 Smarcc2 Nr1i3 Fkbp5 Suv420h1 Nr4a1 Ifng Pomc Pou2f1 BIOCARTA_CDMAC_PATHWAY%MSIGDB_C2%BIOCARTA_CDMAC_PATHWAY BIOCARTA_CDMAC_PATHWAY Hras Prkcb Myc Cuzd1 Jun Plcb1 Fos Raf1 Nfkbia Map2k1 Mapk1 Rela Prkca Nfkb1 BIOCARTA_P53HYPOXIA_PATHWAY%MSIGDB_C2%BIOCARTA_P53HYPOXIA_PATHWAY BIOCARTA_P53HYPOXIA_PATHWAY Igfbp3 Hspa1a Rpa1 Hspa1b Bax Csnk1a1 Tp53 Hif1a Mdm2 Fhl2 Nfkbib Gadd45a Cdkn1a Atm Csnk1d Mapk8 Nqo1 Abcb1a LOC103692716 Akt1 PID_FCER1_PATHWAY%MSIGDB_C2%PID_FCER1_PATHWAY PID_FCER1_PATHWAY Hcls1 Lat2 Pld2 Plcg1 Nfkb1 Ptpn13 Ppap2a Cblb Akt1 Raf1 Mapk1 Fcgr2b Lcp2 Ikbkb Mapk8 Rela Chuk Pxn Hras Fos Gab2 S1pr1 Map2k1 Map2k2 Sos1 Sphk1 Syk Dusp1 Fer Shc1 Rasa1 Nfatc2 Map3k1 LOC100912399 Pla2g4a Vav1 Lat Inpp5d Ptpn11 Ptk2 Pla2g1b Fcer1a Pik3r1 Klrg1 Wipf1 Map2k4 Pak2 Prkcb Jun Fyn Map2k7 Grb2 Cbl Lyn Itk Dok1 PID_ERBB1_DOWNSTREAM_PATHWAY%MSIGDB_C2%PID_ERBB1_DOWNSTREAM_PATHWAY PID_ERBB1_DOWNSTREAM_PATHWAY Pik3cb Gab1 Creb1 Pld2 Pld1 Ywhae F2rl2 Rps6ka3 Bad Prkcz Akt1 Mapkap1 Atf1 Ywhab Dusp6 LOC100911372 Prkcd Raf1 Ywhah Rac1 Map3k2 Ralgds Mapk1 Ywhag Map2k5 Nras Mapk8 Ywhaz Rin1 Ppp2r2a LOC100911794 Prkca Mlst8 Bcl2l1 Mylpf Rps6ka5 Mtor Ksr1 Hras Arf4 Rictor Eps8 Fos Pdpk1 Slc9a1 Map2k1 Sos1 Map2k2 Dusp1 Srf Mef2c Atf2 Smad1 Sfn Map3k1 Kras LOC100912399 Pebp1 Rala Sh2d2a Stat1 Egfr Usp6nl Elk1 Stat3 Pik3r2 Actr3 Arpc4 Arpc5 Pik3r1 Iqgap1 Pik3r3 Map2k4 Mapk9 Egr1 Vav2 Jun Ppp2ca Nckap1 Brk1 Pik3cd Ppp2r1a Arpc3 Grb2 Arpc2 Arpc1b Ppp5c Baiap2 Actr2 Src Abi1 Rps6 Capn2 BIOCARTA_NOS1_PATHWAY%MSIGDB_C2%BIOCARTA_NOS1_PATHWAY BIOCARTA_NOS1_PATHWAY Prkar1b Prkcb Nos1 Ppp3cb Grin2b Prkacb Dlg4 Grin1 Prkar2b Prkar2a Prkca Grin2d Grin2c Ppp3ca BIOCARTA_KREB_PATHWAY%MSIGDB_C2%BIOCARTA_KREB_PATHWAY BIOCARTA_KREB_PATHWAY Cs Sucla2 Ogdh Idh2 Aco2 Sdha Mdh1 Fh ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS%MSIGDB_C2%ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS LOC100911248 Mapk8ip2 Crkl Mapk8ip3 Mapk8ip1 Ntrk1 Creb1 Shc1 Opn1mw Gnaq Egr2 Egr3 Rps6ka3 Mapk10 Creb5 Creb3 Elk1 Ptpn11 Akt1 Map1b Gast Atf1 Egr4 Pik3r1 Th Asah1 Map2k4 Mapk9 Egr1 Camp Jun Dag1 Pik3cd Map2k7 Mapk1 Frs2 Mapk8 Crebbp Src Pik3c2g Terf2ip BIOCARTA_MAL_PATHWAY%MSIGDB_C2%BIOCARTA_MAL_PATHWAY BIOCARTA_MAL_PATHWAY Hras Limk1 Acta1 Raf1 Rac1 Hnf1a Map2k1 Mapk1 Map2k2 Srf Mapk8 Diaph1 Map4k2 Rock1 Map3k1 LOC100912399 Rhoa Mal PID_IL23_PATHWAY%MSIGDB_C2%PID_IL23_PATHWAY PID_IL23_PATHWAY LOC497963 Il6 Il17a Il1b Cd4 Il23a Itga3 Socs3 Ccl12 Il23r Stat5a Nfkb1 Alox12b Stat1 Stat3 Il24 Pik3r1 Cxcl9 Il17f Cxcl3 Nfkbia Mpo Il2 Rela Ifng Il12b Il18r1 Il18 Il19 Cd3e PID_CDC42_REG_PATHWAY%MSIGDB_C2%PID_CDC42_REG_PATHWAY PID_CDC42_REG_PATHWAY Dock6 Racgap1 Spata13 Itsn2 Dock11 Vav3 Farp2 Mcf2l Arhgap17 Fgd1 Arhgap1 Apc Plcg1 Dnmbp Arhgef25 Arhgdia Git1 Vav2 Itsn1 LOC100912512 Ralbp1 Nme1 Arhgef6 Bcar3 Arhgef7 Ngef BIOCARTA_SKP2E2F_PATHWAY%MSIGDB_C2%BIOCARTA_SKP2E2F_PATHWAY BIOCARTA_SKP2E2F_PATHWAY Skp2 Cdk2 Skp1 Rb1 Cul1 Ccne1 E2f1 Ccna1 PID_IGF1_PATHWAY%MSIGDB_C2%PID_IGF1_PATHWAY PID_IGF1_PATHWAY Pxn Hras LOC100911248 Crkl Pdpk1 Irs2 Sos1 Prkd1 Shc1 Ywhae Bad Prkcz Ptpn11 Ptk2 Akt1 Igf1r Pik3r1 Prkcd Ptpn1 Nck2 Igf1 Raf1 Grb2 Crk Irs1 Rps6kb1 Ywhaz Bcar1 Grb10 NABA_MATRISOME_ASSOCIATED%MSIGDB_C2%NABA_MATRISOME_ASSOCIATED NABA_MATRISOME_ASSOCIATED Csf3 P4ha2 Vegfa Ctse Ctsb Inhbe Cxcl9 Cxcl3 Pf4 Cxcl2 Cxcl10 Cxcl11 Ebi3 Cxcl13 Il1a Csf1 Serpinb8 Serpinb7 Serpinb6 Prss1 Egln3 Serpinb10 Serpina12 Serpina11 LOC100912318 Cst7 Ctsa Cst6 Pcsk6 Serpinb9 Pcsk5 Cst5 Adamtsl5 Ctsw Ngf Adamtsl3 Adamtsl4 Astl Csta Serpinb1a Serpina9 Serpinb13 Cst3 Serpinb11 Timp1 Serpinb12 Adamtsl2 Timp2 Timp4 St14 Itih3 F9 Serpind1 Cst11 Tgm1 Cpn2 Hyal2 Hyal3 Hyal1 Pappa Kazald1 Hyal4 Hyal5 RGD1565033 Adamdec1 Tgm3 Tgm4 Cela3b Tgm6 Htra3 Serpinb3a Fst Lgals7 Bmp7 Serpina10 Wnt16 Chrdl1 Chrd Ntf3 Grem1 Bmp4 Bmp2 Serpinb2 Serpinc1 Shh Tdgf1 Tnfsf13b Tgfb2 Anxa4 Tnfsf13 Egln2 Plat Csf2 Ccl12 Osm Gdnf Fgf16 Fgf22 S100a4 Angptl4 Mmp1 Lif Serpinb5 Sema4d Clec5a Tll2 Adamts15 Pamr1 Adamts16 Prss12 Ogfod1 Adam28 Pdgfb Adamts14 F7 Loxl4 Cst9l Sdc4 Loxl1 Habp2 Sdc3 Adamts19 Sdc2 Serpinf1 Serpinf2 P3h2 P3h1 Sulf2 Serpinh1 Cstl1 Fam20b Mmp28 Fam20a Tmprss15 Adam32 Adam33 Ogfod2 Mmp21 Mmp20 Sulf1 Adam30 Adam7 Serpini2 Plod1 Serpini1 Plod3 F13a1 Mmp16 Adamts9 P4ha1 P3h3 Mmp27 Fam20c Mmp23 Adam2 P4ha3 Plod2 Adam8 Ctsf Ctsc Cela2a Plxnb2 Cd109 Serpina5 LOC299282 Serpina7 Cstb Adamts7 Adamts6 Cxcl12 Hpse Mmp17 Mmp19 Adamts4 Cela1 Gpc4 Adamts3 Il16 Il10 Il17a Il15 Il13 Lta Il9 Agt Pgf Anxa2 Tgm2 Fgf4 Adam12 Adam18 Serpine3 Adamts12 Adam19 Ambp Ky Lox Serpine2 P4htm Il12a Inha Ifng Adam11 Il12b Il18 Ccl5 Lefty1 Lgals3 Ccl3 Ccl2 Wnt10a Wnt10b Dhh Ccl1 Epo Mst1 Il23a Anxa13 Hcfc2 Il36rn Egfl6 Crlf1 Pdgfa Egfl8 Thpo Hbegf Nrg1 Il1f10 Wnt2b Bmp15 Sfrp5 Sfrp4 Sfrp2 Sfrp1 Gdf11 Gdf10 Cntf Gdf15 Btc Wnt3a Tgfb1 Tgfa Hhip Il17d Il17c Il17b Ptn Ccl24 Ccl22 Ccl28 Il17f Lefty2 Ccl21 Ccl20 Tnfsf4 Igf2 Fstl3 Fstl1 Tgfb3 Frzb Ccl19 Angpt1 Ppbp Wnt6 Mmp2 Ihh Angpt4 Ccl17 Wnt11 Fgf2 Wnt4 Wnt3 Inhbb Ccbe1 Anxa5 F2 S100a16 Sema3b Plg S100a10 S100a13 Pspn Angpt2 Inhba Inhbc Adam17 Adamts5 LOC100912356 S100a3 S100a1 Adam15 Cxcl1 Cx3cl1 Mstn Lep Cxcl6 Adam23 Xcl1 Scube3 Crnn Scube1 S100a9 S100a8 Wif1 S100a6 S100a5 Il2 LOC100911486 Faslg Wnt5b Clcf1 Chrdl2 Wnt5a Cd209a Serpine1 Anxa10 Plau Sema4g Ctsg Frem1 Sema4c Sema4f Mmp9 Sema4a Ins2 Sema4b Colec12 Clec4b2 Igf1 Sema6d Sema6b Reg3g Reg3b Emcn Sema5a Clec4a Frem2 Frem3 C1qtnf2 C1qtnf3 C1qtnf4 C1qtnf5 C1qtnf7 Mmp12 Hpx Muc1 Plxnb1 Mmp13 Sema3g Sema3f Colec10 Angptl3 Hgf Sema3e Sema3d Sema3a C1qtnf9 C1qtnf1 F10 Il4 Il5 Kitlg Il6 Il1b Anxa9 Elane Ccl11 Hgfac Sftpa1 Ccl4 Lgals1 LOC100911854 Ngly1 Mbl2 Prl Ccl25 Itih4 Itih1 Ctsd Serpina1 Anxa3 Clec14a Bmp1 Fcnb Plxna2 Cspg4 Cspg5 Lgals12 Plxnd1 C1ql1 C1ql4 Sema6c Sema6a Mmp8 Anxa6 Sema7a C1ql3 Mmp7 Anxa7 Reg4 Htra1 Lgals2 Muc15 Anxa1 Muc13 Masp2 Anxa11 Clec1a Clec11a Clec10a Lgalsl Sftpc Sftpb Lman1l Lgals4 Lgals9 Lgals8 Itln1 Clec4m Clec4f Clec4e Clec4d F12 Serping1 Mep1a Plxdc2 Plxdc1 Parm1 Clec2l Clec3a Muc20 Gpc2 Elfn1 Mmp10 Mmp15 Adam9 Mmp14 F13b Mmp11 Ctsl Ctsk Timp3 Cbln1 Il36b Megf6 Sema3c Tnfsf10 Wfikkn1 Cbln3 Il36a Ntf4 Cbln2 Fgf5 Fgf6 Fgf7 Fgf8 Wfikkn2 Bmp3 Fgf1 Fgf3 Il36g Fgfbp1 Wnt1 Vegfc Fgfbp3 Il34 Fgf9 Ctf1 Cxcl14 Il22 Il20 Il25 Bmp6 Il24 Serpina6 Reg1a Prmt2 Fgf20 Fgf21 Mdk Fgf23 Ifnb1 Pik3ip1 Insl3 Angptl1 Angptl2 Angptl6 Lman1 Vwc2l Insl6 Fgf12 Fgf13 Adamts1 Fgf10 Wnt7a Wnt7b Fgf11 Fgf14 Fgf17 Serpina4 Bdnf Nodal Tnfsf12 Fgf19 Tnfsf14 Tnfsf15 Wnt8b Wnt8a Gdf3 Tpo Gdf7 Gdf2 Megf9 C1qa S100b Pdgfc C1qb Gdf6 S100z S100g C1qc Wnt9a Ereg Gdf9 Nrg3 Rptn A2m Wnt9b Nrg4 Ccl7 Eda Il7 Megf10 Figf Bmp8a Nrg2 Zfp91 Ifnk Megf11 Crhbp Il1rn Artn Nrtn Areg Amh Il11 Brinp3 Cbln4 Brinp2 Il19 Vwc2 HALLMARK_APOPTOSIS%MSIGDB_C2%HALLMARK_APOPTOSIS HALLMARK_APOPTOSIS Lgals3 Satb1 Diablo Clu Atf3 Avpr1a Cdkn1b Ebp Ankh Dnaja1 Gadd45b Erbb2 Tnfrsf12a Rara Cth Cd14 Hspb1 Sc5d Ifngr1 Wee1 Gadd45a Smad7 Gstm7 Irf1 Mmp2 Gpx1 Xiap Cd44 F2 Sqstm1 Tgfbr3 Il1a Madd Pdcd4 Ppt1 Bik Cyld Gucy2d Psen1 Ccnd1 Pea15 Anxa1 Egr3 Timp1 Timp2 Dcn Casp4 Casp2 Lmna Plcb2 Hmox1 Gna15 Faslg Ppp3r1 Cdc25b Btg2 Timp3 Tap1 Ddit3 Tnfsf10 Hmgb2 Dap3 Brca1 Bmf F2r Cflar Cd2 Cdkn1a Dnajc3 Casp8 Nedd9 Vdac2 Dap Rhot2 Fdxr Lef1 Bmp2 Retsat Sod2 Sod1 Fez1 Krt18 Dnm1l Rnasel Igf2r Aifm3 Txnip Bcl2l10 Slc20a1 Gsn Eno2 Lppr4 Mgmt App Cdk2 Bcl2l11 Sptan1 Ifitm3 LOC100911625 Tspo Tgfb2 Crebbp Erbb3 Bcl2l2 Pdgfrb Rela Emp1 Rock1 Hgf Isg20 Btg3 Gch1 Ccna1 Bcl2l1 Casp6 Gpx3 Bid Casp9 Bcap31 Casp3 Il6 Add1 Bax Casp1 Il1b Ifnb1 Etf1 Plat Birc3 Fas Gsr Nefh Rhob Pak1 Dffa Bcl10 Ptk2 Psen2 Lum Ereg Jun Cd69 Igfbp6 Cd38 LOC100909468 Ppp2r5b Ier3 Bnip3l Sat1 Gpx4 Il18 BIOCARTA_SRCRPTP_PATHWAY%MSIGDB_C2%BIOCARTA_SRCRPTP_PATHWAY BIOCARTA_SRCRPTP_PATHWAY Src Prkcb Cdc25b Cdk1 Cdc25a Cdc25c Prkca Grb2 Csk Ptpra ST_JAK_STAT_PATHWAY%MSIGDB_C2%ST_JAK_STAT_PATHWAY ST_JAK_STAT_PATHWAY Reg1a Pias1 Jak3 Jak1 Ptpru Cish Soat1 Pias3 BIOCARTA_P38MAPK_PATHWAY%MSIGDB_C2%BIOCARTA_P38MAPK_PATHWAY BIOCARTA_P38MAPK_PATHWAY Tradd Ddit3 Ripk1 Hras Mapk14 Myc Mapkapk5 Mef2c Creb1 Shc1 Atf2 Map3k1 LOC100912399 Mapkapk2 Pla2g4a Stat1 Elk1 Tgfb1 Map3k9 Daxx Map2k4 Hspb1 Max Mef2d Map3k7 Mknk1 Rac1 Grb2 Rapgef2 Tgfb3 Map2k6 Tgfb2 Traf2 Tgfbr1 Rps6ka5 Hspb2 PID_WNT_NONCANONICAL_PATHWAY%MSIGDB_C2%PID_WNT_NONCANONICAL_PATHWAY PID_WNT_NONCANONICAL_PATHWAY Flna Cthrc1 Camk2a Dvl1 Nfatc2 Mapk10 Rhoa Prkcz Nlk Mapk9 Csnk1a1 Fzd6 Fzd2 Map3k7 Rac1 Yes1 Tab2 Ror2 Chd7 Mapk8 Arrb2 Pparg Wnt5a Dvl3 Rock1 Daam1 Fzd5 PID_ERBB_NETWORK_PATHWAY%MSIGDB_C2%PID_ERBB_NETWORK_PATHWAY PID_ERBB_NETWORK_PATHWAY Ereg Nrg3 Nrg4 Nrg2 Hbegf Nrg1 Erbb4 Erbb3 Areg LOC103692716 Egfr Btc Erbb2 Tgfa BIOCARTA_PTC1_PATHWAY%MSIGDB_C2%BIOCARTA_PTC1_PATHWAY BIOCARTA_PTC1_PATHWAY Ptch1 Ccnh Shh Cdc25b Cdk1 Cdc25a Cdc25c Cdk7 Xpo1 Mnat1 HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION%MSIGDB_C2%HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION Igfbp3 Ppib Cthrc1 Mcm7 Slit3 Crlf1 Lgals1 Vegfa Scg2 Pmp22 Sfrp4 Col5a1 Sfrp1 Gadd45b Tnfrsf12a Tgfb1 Anpep Cxcl3 Postn Fstl3 Tnfrsf11b Fstl1 Gadd45a Dab2 Mmp2 Fmod Matn2 Itga5 Cd44 Fgf2 Nid2 Matn3 Ctgf Fn1 Tgfbr3 Qsox1 Eln Cdh11 Inhba Bmp1 Myl9 Tfpi2 Htra1 Cdh2 Timp1 Vim Cdh6 Mmp1 Gja1 Cxcl6 Dcn Thy1 Mgp Msx1 Mmp14 Wnt5a Timp3 Flna Serpine1 Fbln5 Fbln2 Prrx1 Cadm1 Sdc4 Fuca1 Loxl1 Col4a2 Grem1 Col4a1 P3h1 Vegfc Serpinh1 Aplp1 Eno2 Lrp1 Lama1 Igfbp2 Plod1 Plod3 Emp3 Capg Slit2 Mylk Ptx3 Plod2 LOC100911625 Nt5e Mest Pdgfrb Notch2 Tagln Cxcl12 Sparc Il6 Spp1 Fbln1 Vcam1 Il15 Thbs2 Itgb1 Sgcg Oxtr Fap Fas Gpx7 Cd59 Mfap5 Rgs4 Col1a1 Col5a3 Sgcd Tpm2 Bdnf Col5a2 Col1a2 Col3a1 Rhob Col8a2 Col6a2 Col11a1 Wipf1 Lum Tgm2 Jun Pmepa1 Col16a1 Cyr61 Vcan Adam12 Fbn1 Basp1 Pfn2 LOC100909840 Lrrc15 Lamc1 Sgcb Lamc2 Dpysl3 Magee1 Sntb1 Lox Serpine2 Colgalt1 Pcolce Dkk1 Nnmt Areg Id2 Ecm1 Sat1 Fermt2 Igfbp4 Glipr1 BIOCARTA_PGC1A_PATHWAY%MSIGDB_C2%BIOCARTA_PGC1A_PATHWAY BIOCARTA_PGC1A_PATHWAY Esrra Ppargc1a Ppara Ppp3cb Mef2d Camk2d Camk2g Ywhah Camk4 Mef2c Camk2a Camk1g Camk1 Slc2a4 Ppp3ca BIOCARTA_P27_PATHWAY%MSIGDB_C2%BIOCARTA_P27_PATHWAY BIOCARTA_P27_PATHWAY Skp2 Cdk2 Nedd8 Rb1 Skp1 Rbx1 Cul1 E2f1 Cdkn1b Cks1b Ccne1 Ube2m Cks1l BIOCARTA_PTDINS_PATHWAY%MSIGDB_C2%BIOCARTA_PTDINS_PATHWAY BIOCARTA_PTDINS_PATHWAY Vav2 Eea1 Pdpk1 Rac1 Arhgef2 Rps6kb1 Lyn Gsk3b Gsk3a Plcg1 Pfkl Pfkp Ap2m1 Jag1 Bad Prkcz Ap2a1 Akt1 BIOCARTA_GLYCOLYSIS_PATHWAY%MSIGDB_C2%BIOCARTA_GLYCOLYSIS_PATHWAY BIOCARTA_GLYCOLYSIS_PATHWAY Aldob Gpi Pfkl Eno1 Pgk1 Pklr BIOCARTA_NUCLEARRS_PATHWAY%MSIGDB_C2%BIOCARTA_NUCLEARRS_PATHWAY BIOCARTA_NUCLEARRS_PATHWAY Cyp2e1 Cyp1a2 Nr1i3 Pparg Ppara Abcb1a Nr0b2 Nr1h4 Ppard Nr1h3 Rara SA_PTEN_PATHWAY%MSIGDB_C2%SA_PTEN_PATHWAY SA_PTEN_PATHWAY Pten Pik3cd Mapk1 Grb2 Sos1 Shc1 Ilk Rbl2 Ptk2b Pdk1 Bpnt1 Akt2 Akt3 Akt1 PID_PDGFRA_PATHWAY%MSIGDB_C2%PID_PDGFRA_PATHWAY PID_PDGFRA_PATHWAY Csnk2a1 Pik3r1 Jak1 Cav3 Pdgfra Shf LOC100911248 Jun Fos Crkl Grb2 Sos1 Crk Srf Shc1 Plcg1 Ifng Elk1 PID_TCPTP_PATHWAY%MSIGDB_C2%PID_TCPTP_PATHWAY PID_TCPTP_PATHWAY Pik3cb Stat6 Jak3 Pias1 Jak1 Pdgfb Itgb1 Lman1 Gab1 Sos1 Stat5b Vegfa Shc1 Stat5a Kpna2 Rab4a Stat1 Egfr Stat3 Pik3r2 Atr Pik3r1 Pik3r3 Ins2 Insr Ptpn1 Pik3cd Grb2 Ptpn2 Crebbp Src Pdgfrb Hgf Kpnb1 Eif2ak2 Eif2a Csf1 Csf1r HALLMARK_MITOTIC_SPINDLE%MSIGDB_C2%HALLMARK_MITOTIC_SPINDLE HALLMARK_MITOTIC_SPINDLE Mark4 Fgd6 Pcgf5 Cep72 Cep131 Arl8a Lats1 Espl1 Rabgap1 Tubgcp2 Cdc42ep2 Katna1 Cdc42ep1 Smc4 Pdlim5 Mid1ip1 Kif5b Palldl1 Plekhg2 Mid1 Ndc80 Anlnl1 Map1s Tlk1 Kifap3 Ppp4r2 Clip2 Ssh2 Numa1 Cenpj Kif4a Ywhae Rapgef5 Cntrl Llgl1 Nf1 Pkd2 Dynll2 Katnb1 Dync1h1 Pcm1 Sass6 Dlgap5 Tuba4a LOC100909750 Ckap5 Incenp Pafah1b1 Prc1 Tpx2 Ralbp1 Cdk1 Ttk Kif2c Tsc1 Arfgef1 Cdc27 Sptbn1 Abr Racgap1 Myo9b LOC100911597 Shroom2 Ezr Trio Epb41l2 Kif20b Rasa1 Net1 Ect2 Cdc42bpa Mapre1 Kif23 Cdk5rap2 Bub1 Lrpprc Myh10 Smc3 Shroom1 Cep250 Arhgap10 Cttn Atg4b Cntrob Lmnb1 Tubgcp5 Itsn1 Aurka Stau1 Tubgcp6 Dlg1 Capzb Sept9 Alms1 Tiam1 Sun2 Tubgcp3 Hdac6 Csnk1d Fbxo5 Arhgap29 Abi1 Als2 Kif3c Cenpf Arf6 Cep57 Smc1a Cenpe Nusap1 Flna Ophn1 Nedd9 Apc Flnb Rhot2 Nin Cd2ap Gsn Klc1 LOC100911256 Plk1 Myh9 Brca2 Uxt Wasf1 Bcl2l11 Sptan1 Kif11 Arhgef3 Arhgef2 Arhgef7 Kif15 Bcar1 Abl1 Farp1 Notch2 Rock1 Arhgap5 Rasal2 Arhgef11 Kif22 Rasa2 Actn4 Pxn Rictor Bin1 Sos1 Prex1 Rapgef6 Epb4.1 Nck1 Arhgdia Nck2 Map3k11 Arfip2 Vcl Rfc1 Synpo Cyth2 PID_AR_NONGENOMIC_PATHWAY%MSIGDB_C2%PID_AR_NONGENOMIC_PATHWAY PID_AR_NONGENOMIC_PATHWAY Hras Fos Map2k1 Map2k2 Creb1 Pelp1 Plcg1 Ptk2 Ar Akt1 Gnai1 Pik3r1 Raf1 Plcb1 Rac1 Mapk1 Plcb2 Gnai3 Shbg Gnrh1 Src Gnao1 Gnai2 Plcb3 Gnaz Gnb1 PID_INTEGRIN1_PATHWAY%MSIGDB_C2%PID_INTEGRIN1_PATHWAY PID_INTEGRIN1_PATHWAY Plau Itga3 Col4a3 Col6a1 Col4a1 Col11a2 Vegfa Col4a5 Col5a1 LOC100911572 Fga Fgg Fgb Lama1 Itga4 Cd14 Itga11 Itga8 Itga7 F13a1 Itga10 Itga6 Lama4 Itga5 Col18a1 Fn1 Nid1 Vtn Lamb3 Mdk Lamb2 Cspg4 Spp1 Vcam1 Thbs2 Itgb1 Col1a1 Col5a2 Col1a2 Col3a1 Igsf8 Col6a2 Col11a1 Tgm2 Fbn1 Lamc1 Lamc2 Cd81 Lamb1 PID_ER_NONGENOMIC_PATHWAY%MSIGDB_C2%PID_ER_NONGENOMIC_PATHWAY PID_ER_NONGENOMIC_PATHWAY Mapk11 Hras Rock2 Sos1 Gna11 Hbegf Esr1 Shc1 Pelp1 Gnaq Kras Rhoa Nos3 Esr2 Akt1 Gnai1 Igf1r Pik3r1 Mmp9 Igf1 Plcb1 Grb2 Plcb2 Gna14 Gna15 Nras Gnai3 Mmp2 Gnao1 Src Bcar1 Gnai2 Strn Msn Plcb3 Gnaz Gna13 Gnb1 Gnal BIOCARTA_CBL_PATHWAY%MSIGDB_C2%BIOCARTA_CBL_PATHWAY BIOCARTA_CBL_PATHWAY Src Prkcb Pdgfra Sh3kbp1 Prkca Egfr Grb2 Cbl Sh3glb1 Csf1r PID_RAC1_REG_PATHWAY%MSIGDB_C2%PID_RAC1_REG_PATHWAY PID_RAC1_REG_PATHWAY Dock6 Racgap1 Abr Spata13 Vav3 Eps8 Arhgap17 Arhgap1 Sos1 Trio Prex1 Def6 Vav1 Arhgap9 Arhgef25 Arhgdia Dock1 Vav2 LOC100912512 Kalrn Rac1 Arhgef2 Tiam1 Ralbp1 Arhgef6 Arhgef7 Rap1gds1 Abi1 Ngef Prex2 LOC100909609 BIOCARTA_CHREBP2_PATHWAY%MSIGDB_C2%BIOCARTA_CHREBP2_PATHWAY BIOCARTA_CHREBP2_PATHWAY Ppp2r5a Ppp2r3a Prkaca Prkacb Pklr Prkar2b Prkar2a Ywhae Prkag2 Prkab2 Prkag3 Prkab1 Ywhab Prkar1b Prkaa1 Prkaa2 Ppp2r1b Ppp2ca Ywhah Ppp2r1a Ywhag LOC100909468 Ppp2r5b Ywhaz Ppp2r2a Ppp2r4 Ppp2cb Ppp2r2d Ppp2r5c Mlx Ppp2r5e HALLMARK_COMPLEMENT%MSIGDB_C2%HALLMARK_COMPLEMENT HALLMARK_COMPLEMENT Hspa1a Ccl5 Hspa1b Lgals3 Me1 Clu Itgam Kynu C4bpb Zeb1 Cr2 Gzma Lamp2 Ctsb Pla2g7 Pik3r5 Plscr1 Dusp6 C3 Cxcl3 Raf1 LOC100909857 Gpd2 Irf1 Kif2a Itih1 Anxa5 Fn1 F2 Plg S100a13 Ppp2cb Lgmn Ctsd Serpina1 Fcnb Gngt2 Prss1 Tfpi2 Cfh Psen1 Plek Apoc1 Cp Ltf Rabif Mmp8 Csrp1 Dpp4 Gp9 Gzmk Zfpm2 Timp1 Klk1c2 Car2 Prcp Olr1 Timp2 Cpq Lta4h Lck Gp1ba F8 Stx4 Tmprss6 Dyrk2 Dusp5 Serping1 Pik3cg Casp4 Gnb2 S100a9 Prep RGD1563962 Mmp15 Gnai3 Ang2 Lyn Sirt6 Src Adam9 Gnai2 Mmp14 Rhog Klkb1 Ctsl Pcsk9 Rasgrp1 Serpine1 Ehd1 Lap3 Mt3 Pdgfb Psmb9 Kcnip3 Rce1 F7 Cd46 Gca Msrb1 Col4a2 Usp14 Usp16 Dgkg Pfn1 Rnf4 C2 Cd40lg Prss36 Irf2 Adra2b Cd55 Brpf3 Xpnpep1 Gmfb Phex Vcpip1 Gnb4 Prdm4 Pdp1 Akap10 Hpcal4 Rbsn Cblb Lipa Serpinb2 Cpm Fdx1 Ppp4c Lrp1 Serpinc1 Irf7 Prkcd Cdk5r1 Hspa5 Lcp2 Maff F3 Ctsc Mmp12 Mmp13 Cdh13 C1s F10 Gata3 Casp9 Casp3 Il6 Casp1 Plat Atox1 Cd59 Pim1 Pla2g4a Scg3 C1qa C1r C1qc C9 Usp8 Fyn Notch4 Usp15 Grb2 Actn2 Cda Hnf4a PID_LYSOPHOSPHOLIPID_PATHWAY%MSIGDB_C2%PID_LYSOPHOSPHOLIPID_PATHWAY PID_LYSOPHOSPHOLIPID_PATHWAY Pik3cb Gab1 Hbegf Gsk3b Pld2 Gnaq Plcg1 Nfkb1 Rhoa Akt1 Gnai1 Mmp9 Prkcd Adcy6 Lpar2 Lpar1 Nfkbia Rac1 Adcy8 Lpar3 Adcy3 Magi3 Adcy5 Mmp2 Adcy4 Bcar1 Gna12 Gna13 Lpar4 Rela Pxn Slc9a3r2 Il6 Hras Casp3 Fos Gna11 Prkd1 Ptk2b Egfr Ptk2 Pik3r1 Adcy7 Jun Tiam1 Gna14 Crk Gna15 Gnai3 Lyn Src Gnao1 Gnai2 Plcb3 Gnaz Gnb1 BIOCARTA_RARRXR_PATHWAY%MSIGDB_C2%BIOCARTA_RARRXR_PATHWAY BIOCARTA_RARRXR_PATHWAY Hdac3 Rxra Gtf2b Gtf2f1 Ncoa1 Gtf2e1 Ncoa2 Gtf2a1 Tbp Ncor2 Ercc3 Polr2a Rara PID_S1P_S1P2_PATHWAY%MSIGDB_C2%PID_S1P_S1P2_PATHWAY PID_S1P_S1P2_PATHWAY Gnai1 Mapk14 S1pr2 Jun Fos Cdh5 Rac1 Mapk1 Gna14 Irs1 Gna11 Gna15 Mapk8 Gnai3 Gnao1 Gnai2 Gna12 Gnaz Gna13 Gnaq Rhoa Pak1 Elk1 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES%MSIGDB_C2%SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Serpinb6 Foxo1 Cyth3 Irs2 Sos1 Shc1 Pard3 Gsk3b Gsk3a Slc2a4 Ywhae Sfn F2rl2 Rps6ka3 Pdk1 Akt2 Akt3 Akt1 Flot1 Pik3r1 Flot2 Ywhab Rps6ka2 Brd4 Ptpn1 Pard6a Raf1 Pten Ywhah Pik3cd Grb2 Mapk1 Ywhag Cap1 Irs1 Cbl Rps6kb1 Ywhaz Cdkn2a Rps6ka1 Igfbp1 Sorbs1 BIOCARTA_RELA_PATHWAY%MSIGDB_C2%BIOCARTA_RELA_PATHWAY BIOCARTA_RELA_PATHWAY Hdac3 Tradd Ripk1 Fadd Nfkbia Tnfrsf1a Tnfrsf1b Ikbkb Crebbp Rela Chuk Nfkb1 Traf6 PID_VEGFR1_2_PATHWAY%MSIGDB_C2%PID_VEGFR1_2_PATHWAY PID_VEGFR1_2_PATHWAY Ptpn6 Mapk14 Gab1 Hsp90ab1 Vegfa Camkk2 Flt1 Plcg1 LOC103692716 Mapkapk2 Rhoa Nos3 LOC100911280 Akt1 Prkcd Fbxw11 Raf1 Cdh5 Myof Mapk1 Rock1 Prkca Fes Vtn Pxn Mapk11 Akap1 Prkaca Pdpk1 Map2k1 Map2k2 Ptprj Ptk2b Sh2d2a Dnm2 Ptpn11 Ptk2 Prkab1 Nck1 Iqgap1 Pik3r1 Pak2 Prkcb Prkaa1 Nck2 Prkaa2 Ctnna1 Fyn Grb2 Ptpn2 Cbl Map2k6 Src Vcl Grb10 BIOCARTA_ACTINY_PATHWAY%MSIGDB_C2%BIOCARTA_ACTINY_PATHWAY BIOCARTA_ACTINY_PATHWAY Actr3 Nck1 Arpc4 Arpc5 Pir Wasf1 Acta1 Nckap1 Rac1 Arpc3 Psma7 Arpc2 Abi2 Arpc1b Actr2 Ntrk1 BIOCARTA_LONGEVITY_PATHWAY%MSIGDB_C2%BIOCARTA_LONGEVITY_PATHWAY BIOCARTA_LONGEVITY_PATHWAY Pik3r1 Igf1r Hras Igf1 Pik3cg Cat Foxo3 Shc1 Sod2 Sod3 Sod1 Ghr Akt1 PID_WNT_CANONICAL_PATHWAY%MSIGDB_C2%PID_WNT_CANONICAL_PATHWAY PID_WNT_CANONICAL_PATHWAY Ppp2r5a Pip5k1b Apc Csnk1g1 Lrp6 Gsk3b Gsk3a Dvl1 Wnt3 Dvl3 Nkd2 Ranbp3 Cul3 Pi4k2a Fzd5 Wnt3a Klhl12 SA_B_CELL_RECEPTOR_COMPLEXES%MSIGDB_C2%SA_B_CELL_RECEPTOR_COMPLEXES SA_B_CELL_RECEPTOR_COMPLEXES Hras Vav3 Vav2 Blnk Jun Fos Rac1 Mapk8ip3 Grb2 Map2k1 Mapk1 Sos1 Syk Shc1 Lyn Atf2 Pappa Map3k1 Rps6ka1 LOC100912399 Rps6ka3 Vav1 Elk1 PID_INTEGRIN_A9B1_PATHWAY%MSIGDB_C2%PID_INTEGRIN_A9B1_PATHWAY PID_INTEGRIN_A9B1_PATHWAY LOC497963 Adam15 Pxn Spp1 F13a1 Vcam1 Tgm2 Itgb1 Rac1 Adam2 Csf2 Adam12 Figf Paox Adam8 Vegfc Vegfa Src Bcar1 Fn1 Sat1 Kcnj15 BIOCARTA_SET_PATHWAY%MSIGDB_C2%BIOCARTA_SET_PATHWAY BIOCARTA_SET_PATHWAY Dffb Crebbp Anp32a Hmgb2 Set Gzma Apex1 Dffa Nme1 PID_PI3KCI_PATHWAY%MSIGDB_C2%PID_PI3KCI_PATHWAY PID_PI3KCI_PATHWAY Pik3cb Hras Cyth3 Pdpk1 Syk Arf5 Plekha1 Dapp1 LOC103692716 Plcg1 Kras Rhoa Inpp5d Lat Lck Sgk1 Pik3r2 Pik3r5 Pik3r1 Pik3r3 Fgr Hck Zap70 Blnk Pik3cg Pten Fyn Pik3cd Blk Rac1 Yes1 Nras Foxo3 Pik3r6 Src Lyn Arf6 Rap1a Itk Cyth1 Cyth2 BIOCARTA_ASBCELL_PATHWAY%MSIGDB_C2%BIOCARTA_ASBCELL_PATHWAY BIOCARTA_ASBCELL_PATHWAY Cd40lg Il4 Il2 RT1-Db1 Faslg Cd40 Il10 Cd28 Cd4 Cd80 Fas RT1-Da NABA_ECM_AFFILIATED%MSIGDB_C2%NABA_ECM_AFFILIATED NABA_ECM_AFFILIATED Sftpa1 Lgals3 Anxa13 Lgals1 LOC100911854 Mbl2 Anxa5 Sema3b Anxa3 Clec14a Fcnb Plxna2 Cspg4 Cspg5 Lgals12 Plxnd1 C1ql1 C1ql4 Sema6c Sema6a Anxa6 Sema7a C1ql3 Anxa7 Reg4 Lgals2 Anxa1 Muc15 Muc13 Anxa11 Clec1a Clec11a Clec10a Lgalsl Sftpc Sftpb Lman1l Lgals4 Lgals9 Lgals8 Itln1 Clec4m Clec4f Clec4e Clec4d Plxdc2 Plxdc1 Parm1 Clec2l Clec3a Muc20 Gpc2 Elfn1 Sema4d Clec5a Cd209a Sema3c Lgals7 Anxa10 Sdc4 Sdc3 Sdc2 Grem1 Sema4g Frem1 Sema4c Sema4f Sema4a Sema4b Colec12 Clec4b2 Sema6d Sema6b Reg3g Reg3b Emcn Clec4a Sema5a Frem2 Frem3 C1qtnf2 C1qtnf3 C1qtnf4 Plxnb2 C1qtnf5 C1qtnf7 Muc1 Hpx Plxnb1 Anxa4 Sema3g Sema3f Colec10 Sema3e Sema3d Sema3a Gpc4 C1qtnf9 C1qtnf1 Reg1a Anxa9 Lman1 C1qa C1qb C1qc Anxa2 PID_WNT_SIGNALING_PATHWAY%MSIGDB_C2%PID_WNT_SIGNALING_PATHWAY PID_WNT_SIGNALING_PATHWAY Fzd6 Fzd4 Cthrc1 Fzd2 Atp6ap2 Ryk Wif1 Ror2 Wnt7a Wnt7b Wnt1 Kremen2 Lrp6 Fzd1 Fzd9 Dkk1 Wnt3 Wnt5a Igfbp4 Lrp5 Rspo1 Fzd5 Wnt3a PID_RETINOIC_ACID_PATHWAY%MSIGDB_C2%PID_RETINOIC_ACID_PATHWAY PID_RETINOIC_ACID_PATHWAY Rxra Ccnh Mapk14 Prkaca Hdac1l Vdr Cdk7 Rxrg Rbp1 Rxrb Hdac1 Rara Mnat1 Akt1 Rarg Hdac3 Nrip1 Ncoa1 Ncoa2 Mapk1 Mapk8 Crebbp Ncor2 Cdk1 Prkca NABA_MATRISOME%MSIGDB_C2%NABA_MATRISOME NABA_MATRISOME Csf3 P4ha2 Vegfa Reln Ctse Ctsb Inhbe Cxcl9 Cxcl3 Pf4 Cxcl2 Cxcl10 Cxcl11 Ebi3 Cxcl13 Il1a Csf1 Serpinb8 Serpinb7 Serpinb6 Prss1 Egln3 Serpinb10 Serpina12 Serpina11 LOC100912318 Cst7 Ctsa Cst6 Pcsk6 Serpinb9 Pcsk5 Cst5 Adamtsl5 Ctsw Ngf Adamtsl3 Adamtsl4 Astl Csta Serpinb1a Serpina9 Serpinb13 Cst3 Serpinb11 Timp1 Serpinb12 Adamtsl2 Timp2 Timp4 St14 Itih3 F9 Serpind1 Cst11 Tgm1 Cpn2 Hyal2 Hyal3 Hyal1 Pappa Kazald1 Hyal4 Hyal5 RGD1565033 Adamdec1 Tgm3 Tgm4 Cela3b Tgm6 Htra3 Serpinb3a Fst Lgals7 Bmp7 Serpina10 Wnt16 Chrdl1 Chrd Ntf3 Grem1 Bmp4 Bmp2 Serpinb2 Igfbp2 Lama1 Serpinc1 Shh Slit2 Srgn Tdgf1 Tnfsf13b Tgfb2 Anxa4 Tnfsf13 Egln2 Plat Csf2 Ccl12 Osm Gdnf Ambn Fgf16 Fgf22 Sspo S100a4 Angptl4 LOC102550316 Ncan Bglap Mmp1 Lif Dcn Serpinb5 Mgp Sema4d Clec5a Tll2 Adamts15 Pamr1 Adamts16 Prss12 Ogfod1 Adam28 Pdgfb Adamts14 F7 Loxl4 Cst9l Sdc4 Loxl1 Col4a2 Habp2 Sdc3 Col4a3 Adamts19 Sdc2 Serpinf1 Col4a1 Serpinf2 P3h2 P3h1 Sulf2 Serpinh1 Col4a5 Cstl1 LOC100911572 Fam20b Mmp28 Fam20a Tmprss15 Adam32 Adam33 Ogfod2 Mmp21 Mmp20 Sulf1 Adam30 Wisp2 Adam7 Serpini2 Plod1 Serpini1 Plod3 F13a1 Mmp16 Adamts9 P4ha1 P3h3 Mmp27 Fam20c Mmp23 Adam2 P4ha3 Plod2 Adam8 Ctsf Ctsc Plxnb2 Cela2a Cd109 Serpina5 Srpx LOC299282 Serpina7 Cstb Adamts7 Adamts6 Cxcl12 Hpse Mmp17 Sparc Mmp19 Adamts4 Cela1 Gpc4 Adamts3 Igfbp7 Il16 Il10 Il17a Il15 Il13 Lta Il9 Col1a1 Agt Col3a1 Col6a2 Pgf Anxa2 Agrn Tgm2 Cyr61 Vcan Fgf4 Adam12 Adam18 Bcan Serpine3 Adamts12 Adam19 Ambp Ky Lox Serpine2 P4htm Inha Il12a Ifng Adam11 Il12b Aebp1 LOC100910284 Il18 Igfbp3 Ccl5 Fndc7 Wisp3 Lefty1 Lgals3 Egflam Ccl3 Ccl2 Fndc8 Wnt10a Vwa5b1 Wnt10b Tecta Wisp1 Dhh Ccl1 Vwa5b2 Mst1 Cthrc1 Epo Il23a Anxa13 Sbspon Slit3 Hcfc2 Slit1 Il36rn Col6a6 Egfl6 Pdgfa Crlf1 Emid1 Col6a1 Egfl8 Dpt Thpo Omd Hbegf Nrg1 Papln Il1f10 Col11a2 Wnt2b Bmp15 Chad Sfrp5 Prg2 Col5a1 Sfrp4 Fndc1 Colq Sfrp2 Tinagl1 Sfrp1 Crim1 Gdf11 Gdf10 Ltbp1 Cntf Prg3 Gdf15 Prg4 Btc LOC100910891 Wnt3a Tectb Tgfb1 Tgfa Ltbp2 Hhip Ltbp4 Col27a1 Il17d Il17c Spock3 Vwa9 Il17b Ptn Mmrn1 Vwa7 Ccl24 Ccl22 Mmrn2 Vwa1 Ccl28 Dspp Il17f Lefty2 Spon1 Ccl21 Spon2 Nov Ccl20 Tnfsf4 LOC100911714 Igf2 Postn Fstl3 Fstl1 Tgfb3 Frzb Matn1 Angpt1 Ccl19 Ppbp Col23a1 Matn4 Mmp2 Wnt6 Fmod Angpt4 Ihh Matn2 Ccl17 Vit Wnt11 Fgf2 Nid2 Wnt4 Matn3 Wnt3 Ctgf Inhbb Hapln3 Nid1 Fn1 Anxa5 Ccbe1 S100a16 F2 Hapln1 Sema3b S100a10 Plg Hapln4 S100a13 Hapln2 Eln Angpt2 Pspn Inhba Crispld1 Inhbc Amelx Adam17 Adamts5 LOC100912356 S100a3 Adam15 S100a1 Cxcl1 Cx3cl1 Mstn Lep Cxcl6 Adam23 Xcl1 Scube3 Crnn Scube1 S100a9 S100a8 Wif1 S100a6 S100a5 Il2 LOC100911486 Faslg Wnt5b Clcf1 Chrdl2 Wnt5a Cd209a Cilp2 Adipoq Epyc Serpine1 Vwf Fbln5 Srpx2 Fbln2 Igsf10 Anxa10 Plau Fga Fgg Fgb Sema4g Kera Ctsg Frem1 Podnl1 Sema4c Rangap1 Sema4f Mmp9 Ppip5k1 Sema4a Ins2 Emilin2 Sema4b LOC100911378 Colec12 Lrg1 Clec4b2 Igf1 Emilin3 Sema6d Mepe Sema6b Igfbpl1 Reg3g Ogn Reg3b Smoc2 Emcn Nell1 Sema5a Col20a1 Clec4a Frem2 Hmcn1 Frem3 Nell2 C1qtnf2 Lama4 C1qtnf3 Col14a1 C1qtnf4 Aspn C1qtnf5 Svep1 C1qtnf7 Mmp12 Col13a1 Hpx Plxnb1 Muc1 Bmper Mmp13 LOC100910384 Smoc1 Sema3g Dmp1 Sema3f Impg1 Colec10 Hgf Angptl3 Impg2 Sema3e Vtn Lgi1 Sema3d Col17a1 Sema3a Lgi3 C1qtnf9 Fbln7 C1qtnf1 Lgi4 F10 Zp1 Il4 Sparcl1 Il5 Kitlg Lamb3 Lamb2 Il6 Spp1 Fbln1 Mfge8 Il1b Anxa9 Igfals Thbs2 Elane Optc Thbs4 Ntn3 Mfap3 Ntn1 Mfap2 Ccl11 Mfap5 Mfap4 Otol1 Ntn5 Col5a3 Nyx Col9a1 Col5a2 Col1a2 Prelp Col9a2 Col8a1 Vwa5a Igfbp5 Col8a2 Cilp Efemp1 Ntng1 Emilin1 Col22a1 Gldn Col11a1 Gas6 Hgfac Otog Tnr Lum Esm1 Fgl2 Tsku Col16a1 Fras1 Tnn Igfbp6 Fgl1 Fbn1 Creld1 Rspo4 Lamc1 Lamc2 Rspo2 Creld2 Rspo3 Pcolce Oit3 Vwa3a Igfbp4 Ecm1 Igfbp1 Rspo1 Zp4 Lamb1 Zp3 Ibsp Sftpa1 Ccl4 Lgals1 LOC100911854 Ngly1 Mbl2 Prl Ccl25 Itih4 Itih1 Col18a1 Ctsd Anxa3 Serpina1 Clec14a Bmp1 Fcnb Plxna2 Cspg4 Cspg5 Lgals12 Plxnd1 C1ql1 C1ql4 Sema6c Sema6a Anxa6 Mmp8 Sema7a C1ql3 Anxa7 Mmp7 Reg4 Htra1 Lgals2 Anxa1 Muc15 Masp2 Muc13 Anxa11 Clec1a Clec11a Clec10a Lgalsl Sftpc Sftpb Lman1l Lgals4 Lgals9 Lgals8 Itln1 Clec4m Clec4f Clec4e Clec4d F12 Serping1 Mep1a Plxdc2 Plxdc1 Parm1 Clec2l Clec3a Muc20 Gpc2 Elfn1 Mmp10 Mmp15 Adam9 Mmp14 F13b Mmp11 Ctsl Ctsk Timp3 Cbln1 Il36b Megf6 Sema3c Tnfsf10 Wfikkn1 Cbln3 Il36a Ntf4 Cbln2 Fgf5 Fgf6 Fgf7 Fgf8 Wfikkn2 Bmp3 Fgf1 Fgf3 Il36g Fgfbp1 Wnt1 Vegfc Fgfbp3 Il34 Fgf9 Ctf1 Cxcl14 Il22 Il20 Il25 Bmp6 Il24 Serpina6 Prmt2 Reg1a Fgf20 Fgf21 Mdk Fgf23 Ifnb1 Pik3ip1 Insl3 Angptl1 Angptl2 Lman1 Angptl6 Vwc2l Insl6 Fgf12 Fgf13 Adamts1 Fgf10 Wnt7a Wnt7b Fgf11 Fgf14 Serpina4 Fgf17 Bdnf Nodal Tnfsf12 Fgf19 Tnfsf14 Tnfsf15 Wnt8b Wnt8a Gdf3 Tpo Gdf7 Gdf2 C1qa Megf9 C1qb Pdgfc S100b Gdf6 S100z C1qc S100g Wnt9a Ereg Gdf9 Nrg3 A2m Rptn Wnt9b Nrg4 Ccl7 Il7 Eda Megf10 Figf Bmp8a Nrg2 Zfp91 Ifnk Megf11 Crhbp Il1rn Artn Nrtn Areg Amh Il11 Brinp3 Cbln4 Brinp2 Il19 Vwc2 BIOCARTA_IL17_PATHWAY%MSIGDB_C2%BIOCARTA_IL17_PATHWAY BIOCARTA_IL17_PATHWAY Cd8a Kitlg Il6 Cd34 Csf3 Il17a Cd4 Cd2 LOC100911324 Cd3g Cd247 Cd3d Cd3e BIOCARTA_IL7_PATHWAY%MSIGDB_C2%BIOCARTA_IL7_PATHWAY BIOCARTA_IL7_PATHWAY Pik3r1 Jak3 Bcl2 Jak1 Il2rg Pik3cg Fyn Il7 Stat5b Crebbp Stat5a Ptk2b Lck BIOCARTA_NO2IL12_PATHWAY%MSIGDB_C2%BIOCARTA_NO2IL12_PATHWAY BIOCARTA_NO2IL12_PATHWAY LOC497963 Cd4 Cd2 Il12rb2 Cd3g Ccr5 Cxcr3 Il12a Ifng Cd247 Il12b Stat1 Cd3d Cd3e BIOCARTA_ATM_PATHWAY%MSIGDB_C2%BIOCARTA_ATM_PATHWAY BIOCARTA_ATM_PATHWAY Rad51 Rad50 LOC100911267 Brca1 LOC100909750 Jun Tp53 Rbbp8 Stt3a Nfkbia Mdm2 Tp73 Gadd45a Cdkn1a Chek2 Atm Mapk8 Nbn Abl1 Rela Nfkb1 Mre11a BIOCARTA_NKT_PATHWAY%MSIGDB_C2%BIOCARTA_NKT_PATHWAY BIOCARTA_NKT_PATHWAY Il4 Il5 Ccl4 Ccr3 Il4r Cd28 Cd4 Csf2 Cd40lg Ccr7 Tgfb1 Ccr1 Ifngr2 Ifngr1 Tgfb3 Il12rb2 Il2 Tgfb2 Ccr4 Ccr5 Cxcr3 Cxcr4 Il12a Ifng Il12b Il18r1 PID_THROMBIN_PAR4_PATHWAY%MSIGDB_C2%PID_THROMBIN_PAR4_PATHWAY PID_THROMBIN_PAR4_PATHWAY Gna13 Rock1 Gnaq F2rl2 Gnb1 F2 Rhoa Plcb2 Gna14 Rock2 Gna15 Gna11 BIOCARTA_MCM_PATHWAY%MSIGDB_C2%BIOCARTA_MCM_PATHWAY BIOCARTA_MCM_PATHWAY Mcm3 Cdk2 Kitlg Mcm5 Mcm6 Orc6 Mcm7 Orc4 Orc5 Orc3 Mcm2 Cdt1 Cdkn1b Cdc6 Orc1 Ccne1 Mcm4 Orc2 BIOCARTA_MITOCHONDRIA_PATHWAY%MSIGDB_C2%BIOCARTA_MITOCHONDRIA_PATHWAY BIOCARTA_MITOCHONDRIA_PATHWAY Casp6 Bid Casp9 Endog Casp3 Diablo Bak1 Bax Bcl2 Birc3 Casp8 Aifm1 Dffb Cycs Xiap Apaf1 Birc2 Bcl2l1 Dffa Bik HALLMARK_MYC_TARGETS_V2%MSIGDB_C2%HALLMARK_MYC_TARGETS_V2 HALLMARK_MYC_TARGETS_V2 LOC100360453 Tmem97 Ddx18 Pus1 Pa2g4 Nop56 Nop2 Plk4 LOC100360260 Rrp9 Map3k6 Plk1 Mybbp1a Mcm5 Hspd1 LOC100364487 Cdk4 Nolc1 Exosc5 Slc19a1 LOC100911721 LOC100912604 Nip7 Cbx3 Rcl1 Tcof1 Mrto4 Pprc1 Wdr43 Tfb2m Imp4 Farsa Wdr74 Myc Ipo4 Ppan Rabepk Dctpp1 Ndufaf4 Gnl3 Dusp2 Hk2 Mphosph10 Aimp2 Ung Mcm4 Prmt3 Nop16 Noc4l Pes1 Las1l Utp20 Sord Npm1 Slc29a2 Srm HALLMARK_P53_PATHWAY%MSIGDB_C2%HALLMARK_P53_PATHWAY HALLMARK_P53_PATHWAY LOC100910438 Clca2 Rrp8 Aen Rxra Dgka Lrmp Pidd1 Ptpn14 Ccp110 Atf3 Rps12 Tcn2 Cdkn2aip Tp63 Cgrrf1 Traf4 Rhbdf2 Zfp365 Perp LOC100912253 Pdgfa Gls2 Adck3 Phlda3 Socs1 Gpx2 LOC100360573 Tnni1 Rad51c Hbegf Tm4sf1 LOC100910152 Slc7a11 Hexim1 Rab40c Ei24 Rrad Vdr Slc35d1 Tm7sf3 Nudt15 Gm2a LOC100359593 Abhd4 Tprkb Tgfb1 Tgfa Hint1 Eps8l2 LOC100911519 Bak1 Xpc Wwp1 Polh Pcna Acvr1b Gadd45a Blcap LOC103690002 Osgin1 Ppp1r15a Sertad3 Zmat3 Upp1 Alox15b Slc3a2 LOC100360129 Ankra2 Csrnp2 Inhbb Il1a S100a10 Ninj1 Hint1-ps1 Cd82 Trib3 Ip6k2 Ercc5 Nol8 Ctsd H2afj Ldhb Notch1 Cdkn2b S100a4 Slc19a2 Tp53 Plk3 Mdm2 Sphk1 Ikbkap Def6 Ptpre St14 Prkab1 Hdac3 Rchy1 Lif Ccng1 Serpinb5 Itgb4 Epha2 Hmox1 Iscu Btg2 Ppm1d Cd81 Mxd1 Tob1 Rnf19b Ddit3 Tap1 Cebpa F2r Mxd4 Sp1 Fuca1 Abcc5 Klk8 Cdkn1a Plk2 Fdxr Bmp2 Retsat Rgs16 Txnip Mapkapk3 App Tspyl2 Rb1 Rap2b Abat Mknk2 Cdk5r1 Sesn1 Ralgds Ccnk Ctsf Trafd1 Plxnb2 Hspa4l Ifi30 Cdkn2a Apaf1 Steap3 Cdh13 Fam162a Ccnd3 Procr Triap1 Stom LOC100910137 Prmt2 Vamp8 Ddit4 Rpl18 Kif13b Hras Bax Casp1 Fos Pom121 Fas Fgf13 Pmm1 Sfn Vwa5a Ephx1 Ada Tpd52l1 Sec61a1 Jun Krt17 Btg1 Tsc22d1 Baiap2 Foxo3 Klf4 Ier3 Sat1 Ndrg1 Zbtb16 BIOCARTA_PARKIN_PATHWAY%MSIGDB_C2%BIOCARTA_PARKIN_PATHWAY BIOCARTA_PARKIN_PATHWAY Ube2l6 Ube2l3 Ube2g1 Ube2g2 Ube2f Sept5 Gp1bb Gpr37 Sncaip Snca BIOCARTA_ATRBRCA_PATHWAY%MSIGDB_C2%BIOCARTA_ATRBRCA_PATHWAY BIOCARTA_ATRBRCA_PATHWAY Rad51 Hus1 Atr Rad1 Rad50 LOC100911267 Fancc Fancd2 Brca1 Brca2 Rad17 Tp53 Stt3a Chek2 Atm Fance Nbn Mre11a Fancf ST_G_ALPHA_I_PATHWAY%MSIGDB_C2%ST_G_ALPHA_I_PATHWAY ST_G_ALPHA_I_PATHWAY Pik3cb Sos1 C2 Itpr1 Itpka Itpr3 Shc1 Itpkb Ephb2 Akt2 Egfr Akt3 Stat3 Akt1 Kcnj3 Asah1 Kcnj9 Dag1 Raf1 Plcb1 Pitx2 Kcnj5 Mapk1 Plcb2 Grb2 Drd2 Src Plcb3 Plcb4 Terf2ip Rgs20 BIOCARTA_EPO_PATHWAY%MSIGDB_C2%BIOCARTA_EPO_PATHWAY BIOCARTA_EPO_PATHWAY Csnk2a1 Hras Ptpn6 Epo Raf1 Jun Fos Grb2 Map2k1 Sos1 Epor Stat5b Mapk8 Shc1 Stat5a Plcg1 Elk1 BIOCARTA_IGF1_PATHWAY%MSIGDB_C2%BIOCARTA_IGF1_PATHWAY BIOCARTA_IGF1_PATHWAY Csnk2a1 Pik3r1 Igf1r Hras Igf1 Pik3cg Raf1 Jun Fos Map2k1 Grb2 Sos1 Irs1 Srf Mapk8 Shc1 Rasa1 Elk1 Ptpn11 BIOCARTA_EIF2_PATHWAY%MSIGDB_C2%BIOCARTA_EIF2_PATHWAY BIOCARTA_EIF2_PATHWAY Eif2ak4 Eif2ak3 Ppp1ca Gsk3b Eif2s1 Eif2ak1 Eif2s3 Eif2s2 Eif2ak2 Eif2b5 Eif5 PID_IL2_STAT5_PATHWAY%MSIGDB_C2%PID_IL2_STAT5_PATHWAY PID_IL2_STAT5_PATHWAY Il4 Jak3 Jak1 Bcl2 Il2rg Lta Myc Sp1 Gab2 Elf1 Sos1 Stat5b Shc1 Stat5a Cdk6 Ptpn11 Lck Pik3r1 Foxp3 Grb2 Il2 Ccna2 Faslg Il2ra Ccnd3 Bcl2l1 PID_PLK1_PATHWAY%MSIGDB_C2%PID_PLK1_PATHWAY PID_PLK1_PATHWAY Ppp1r12a Ercc6l Spc24 Ninl Golga2 Bub1b Bora Tpt1 Rab1a Cenpu Ppp1cb Rock2 Stag2 Gorasp1 Kiz Ndc80 Cdc25c Ect2 Rhoa Pak1 Kif20a Bub1 Plk1 Fzr1 Sgol1 Incenp Fbxw11 Prc1 Aurka Ppp2ca Ppp2r1a Tpx2 Wee1 Clspn Cdc14b Kif2a Tubg1 Fbxo5 Cdk1 Cdc25b Sspo Cenpe Cdc20 BIOCARTA_CARM_ER_PATHWAY%MSIGDB_C2%BIOCARTA_CARM_ER_PATHWAY BIOCARTA_CARM_ER_PATHWAY Grip1 Brca1 Ccnd1 Hdac2 Hdac1l Mef2c Esr1 Tbp Med1 Pelp1 Ercc3 Carm1 Polr2a Hdac1 Hdac8 Hdac3 Nr0b1 Ppargc1a Nrip1 Gtf2f1 Gtf2e1 Sra1 Phb2 Gtf2a1 Hdac6 Crebbp Ncor2 Hdac11 Hdac10 Hdac4 BIOCARTA_INFLAM_PATHWAY%MSIGDB_C2%BIOCARTA_INFLAM_PATHWAY BIOCARTA_INFLAM_PATHWAY Il4 Il5 RT1-Db1 Il6 Csf3 Il10 Ifnb1 Il15 Cd4 Il13 Lta Csf2 Pdgfa RT1-Da Tgfb1 Il7 Tgfb3 Il2 Tgfb2 Il12a Ifng Il11 Il12b Il1a Csf1 BIOCARTA_IL3_PATHWAY%MSIGDB_C2%BIOCARTA_IL3_PATHWAY BIOCARTA_IL3_PATHWAY Stat5b Shc1 Hras Il3ra Csf2rb Ptpn6 Stat5a Raf1 Fos Grb2 Map2k1 Sos1 PID_NETRIN_PATHWAY%MSIGDB_C2%PID_NETRIN_PATHWAY PID_NETRIN_PATHWAY Map2k1 Ntn1 Map2k2 Trio Camk2a Plcg1 Unc5c Pak1 Rhoa Ptk2 Map1b Pitpna Myo10 Nck1 Pik3r1 Dapk1 Dock1 Fyn Rac1 Dcc Mapk1 Yes1 Src Bcar1 LOC100909609 Unc5b BIOCARTA_PROTEASOME_PATHWAY%MSIGDB_C2%BIOCARTA_PROTEASOME_PATHWAY BIOCARTA_PROTEASOME_PATHWAY Psma6 Psma1 Psma2 Psma4 Psma5 Psmc2 Psmd11 Psmb2 Ube3a Psma3 Psmc4 Psmb3 Ube2a Psmc6 Uba1 Psmb1 Psmd6 Psmb7 Psmb6 Psma7 Psmb5 Psmc3 Psmb4 Rpn2 Psmd12 Psmd8 Psmd14 Rpn1 BIOCARTA_LECTIN_PATHWAY%MSIGDB_C2%BIOCARTA_LECTIN_PATHWAY BIOCARTA_LECTIN_PATHWAY C2 Mbl2 C6 Masp2 LOC100911854 C4a C8a C3 C9 BIOCARTA_HCMV_PATHWAY%MSIGDB_C2%BIOCARTA_HCMV_PATHWAY BIOCARTA_HCMV_PATHWAY Pik3r1 Rb1 Mapk14 Pik3cg Sp1 Map2k1 Mapk1 Map2k2 Map2k6 Creb1 Rela Map3k1 LOC100912399 Nfkb1 Akt1 BIOCARTA_ECM_PATHWAY%MSIGDB_C2%BIOCARTA_ECM_PATHWAY BIOCARTA_ECM_PATHWAY Pik3r1 Pxn Hras Pik3cg Mylk Raf1 Itgb1 Fyn Map2k1 Mapk1 Tln1 Pfn1 Shc1 Src Diaph1 Rock1 Arhgap5 Rhoa Gsn Ptk2 HALLMARK_UV_RESPONSE_DN%MSIGDB_C2%HALLMARK_UV_RESPONSE_DN HALLMARK_UV_RESPONSE_DN Rxra Mapk14 Bckdhb Runx1 Pdlim5 Nfib Cdkn1b Pmp22 Nrp1 Ltbp1 Cited2 Erbb2 Map1b Atp2b1 Ldlr Pten Irs1 Smad7 Dab2 Pparg Mgll Tgfbr2 Prkca Mta1 Tgfbr3 Pias3 Kit Myc Nek7 Add3 Papd7 Dusp1 Prkar2b Atp2b4 Cdc42bpa Slc22a18 Ythdc1 Gja1 Smad3 Vav2 Tfpi Kalrn Dlg1 Synj2 LOC688708 Plcb4 Serpine1 Zmiz1 Fbln5 Bhlhe40 Fhl2 Atp2c1 Sdc2 Gcnt1 Nfkb1 Akt3 Has2 Ppap2b Mgmt Dyrk1a Atxn1 Igf1r Mmp16 Lpar1 Map2k5 Id1 F3 Grk5 Anxa4 Pdgfrb Slc7a1 Notch2 Acvr2a Vldlr Rasa2 Schip1 Cdon Col1a1 Rgs4 Spop Prdm2 Atrn Rbpms Bdnf Cacna1a Adora2b Atp5s Col5a2 Mios Col1a2 Ptprm Col3a1 Pex14 Celf2 Igfbp5 Ica1 Adgrl2 LOC100910792 Apbb2 Efemp1 Dbp Phf3 LOC100909679 Wdr37 Col11a1 Scaf8 Pik3r3 Anxa2 Amph Mrps31 Ddah1 Fzd2 Fyn Cyr61 Cdk13 Pik3cd Mt1 Sfmbt1 Insig1 Kcnma1 Aggf1 Rnd3 Tjp1 Fam179b Lamc1 Inpp4b Ptgfr BIOCARTA_TGFB_PATHWAY%MSIGDB_C2%BIOCARTA_TGFB_PATHWAY BIOCARTA_TGFB_PATHWAY Smad3 Zfyve9 Skil Map3k7 Map2k1 Smad2 Smad7 Tgfb3 Cdh1 Tgfb2 Apc Crebbp Tgfbr2 Tgfbr1 Tgfb1 BIOCARTA_AGR_PATHWAY%MSIGDB_C2%BIOCARTA_AGR_PATHWAY BIOCARTA_AGR_PATHWAY Pxn Itgb1 Sp1 Git2 Pak3 Musk Nrg1 Pak4 Rapsn Dvl1 Chrna1 Pak1 Egfr Chrm1 Pak6 Ptk2 Pak7 Utrn Pak2 Cttn Acta1 Nrg3 Jun Dag1 Rac1 Mapk1 Nrg2 Lama4 Mapk8 Src BIOCARTA_GATA3_PATHWAY%MSIGDB_C2%BIOCARTA_GATA3_PATHWAY BIOCARTA_GATA3_PATHWAY Il4 Junb Il5 Gata3 Prkar1b Prkar2b Maf Mapk14 Prkar2a Il13 Nfatc2 Prkacb PID_P38_MKK3_6PATHWAY%MSIGDB_C2%PID_P38_MKK3_6PATHWAY PID_P38_MKK3_6PATHWAY Map3k4 Mapk11 Map3k6 Mapk14 Map3k10 Gadd45g Map3k7 Rac1 Tab2 Gadd45a Atm Map2k6 Taok1 Traf2 Taok3 Map3k3 Map3k1 LOC100912399 Gadd45b Traf6 Txn1 ST_WNT_BETA_CATENIN_PATHWAY%MSIGDB_C2%ST_WNT_BETA_CATENIN_PATHWAY ST_WNT_BETA_CATENIN_PATHWAY Psen1 Apc Gsk3b Gsk3a Sfrp1 Dvl1 Nkd2 Akt2 Akt3 Akt1 Lrp1 Csnk1a1 Pin1 LOC364561 Nkd1 Wif1 Fstl1 Axin2 Senp2 Tshb Dkk2 Dkk4 Cby1 Mvp Dkk1 Rpsa Ankrd6 Dkk3 Dact1 Ptpra Cxxc4 PID_ENDOTHELIN_PATHWAY%MSIGDB_C2%PID_ENDOTHELIN_PATHWAY PID_ENDOTHELIN_PATHWAY Edn3 Mapk14 Cysltr1 Cysltr2 Gnaq Rhoa Akt1 Gnai1 Prkcd Adcy6 Raf1 Rac1 Adcy8 Mapk1 Adcy3 Mapk8 Adcy5 Adcy4 Bcar1 Gna12 Prkca Ednra Ednrb Hras Fos Slc9a3 Slc9a1 Map2k1 Edn1 Map2k2 Edn2 Gna11 Col1a2 Col3a1 Ptk2b Pla2g4a Prkch Prkcq Mmp1 Prkcb Adcy7 Jun Plcb1 Plcb2 Gna14 Trpc6 Crk Gna15 Gnai3 Gnao1 Src Gnai2 Plcb3 Gnaz Gnal PID_IL4_2PATHWAY%MSIGDB_C2%PID_IL4_2PATHWAY PID_IL4_2PATHWAY Parp14 Ptpn6 Mapk14 Sp1 Irs2 Retnlg Oprm1 aicda Socs1 Socs3 Fcer2 Cd40lg Arg1 Akt1 Il13ra2 Irs1 Rps6kb1 Pigr Ccl17 Bcl6 Fes Tff3 LOC100360218 Bcl2l1 Selp Hmga1 Dok2 Il4 Mtor Il5 Stat6 Jak3 Il10 Ets1 Il4r Jak1 Il2rg Lta Ccl11 Mybl1 Alox15 Col1a1 Stat5b Shc1 Col1a2 Stat5a Egr2 Inpp5d Spi1 Il13ra1 Pik3r1 Thy1 Grb2 Cbl Socs5 NABA_BASEMENT_MEMBRANES%MSIGDB_C2%NABA_BASEMENT_MEMBRANES NABA_BASEMENT_MEMBRANES Lamb3 Lamb2 Ntn3 Col6a6 Ntn1 Col4a2 Col4a3 Col6a1 Col4a1 Ntn5 Papln Col4a5 LOC100911572 Colq Ntng1 Col6a2 Lama1 Agrn Hmcn1 Lama4 Lamc1 Lamc2 Nid2 Nid1 Col18a1 Lamb1 PID_SYNDECAN_4_PATHWAY%MSIGDB_C2%PID_SYNDECAN_4_PATHWAY PID_SYNDECAN_4_PATHWAY Ccl5 Mdk Sdcbp Nudt16l1 Fgf6 Itgb1 Sdc4 Rhoa Dnm2 Ptk2 Lama1 Fgfr1 Mmp9 Prkcd Tfpi Rac1 Adam12 Actn1 Itga5 Fgf2 Gipc1 Cxcr4 Prkca Fn1 Cxcl12 F2 Plg ST_STAT3_PATHWAY%MSIGDB_C2%ST_STAT3_PATHWAY ST_STAT3_PATHWAY Reg1a Jak3 Il6 Src Jak1 Ptpru Cish Pias3 Stat3 BIOCARTA_P53_PATHWAY%MSIGDB_C2%BIOCARTA_P53_PATHWAY BIOCARTA_P53_PATHWAY Cdk2 Rb1 Bax Bcl2 Ccnd1 Tp53 Mdm2 E2f1 Pcna Gadd45a Cdkn1a Cdk4 Atm Apaf1 Ccne1 Timp3 PID_P75_NTR_PATHWAY%MSIGDB_C2%PID_P75_NTR_PATHWAY PID_P75_NTR_PATHWAY Diablo Ripk2 Ntf4 Maged1 Ntf3 Prdm4 Ywhae Omg Ngfr Mag Ndn Rhoa Mageh1 Mapk10 Sort1 Bad Prkcz Ngfrap1 Akt1 LOC100912195 App Zfp110 Lingo1 Rtn4 Bcl2l11 Rtn4r Rhoc Rac1 E2f1 LOC100911293 Ikbkb Mapk8 Aph1b Cycs Xiap Apaf1 Chuk Smpd2 Sqstm1 Plg Traf6 Myd88 Casp6 Casp9 Casp3 Adam17 Psenen Psen1 Tp53 Birc3 Prkacb Mmp7 Ntrk1 Ngf Shc1 Bdnf Furin Rhob Birc2 Arhgdia Pik3r1 Mapk9 Ncstn Prkci ST_INTERLEUKIN_4_PATHWAY%MSIGDB_C2%ST_INTERLEUKIN_4_PATHWAY ST_INTERLEUKIN_4_PATHWAY Il13ra1 Il4 Stat6 Jak3 Il4r Jak1 Il2rg Grb2 Sos1 Rps6kb1 Shc1 Src Serpina4 Ppp1r13b Cish Nr0b2 Iars Akt2 LOC100360218 Akt3 Inpp5d Akt1 BIOCARTA_ERK_PATHWAY%MSIGDB_C2%BIOCARTA_ERK_PATHWAY BIOCARTA_ERK_PATHWAY Hras Myc Itgb1 Ptprr Map2k1 Map2k2 Sos1 Ngf Shc1 Ngfr Egfr Elk1 Stat3 Igf1r Pdgfra Raf1 Mknk2 Mknk1 Ppp2ca Mapk1 Grb2 Gngt1 Src Gnb1 Rps6ka1 Rps6ka5 BIOCARTA_DEATH_PATHWAY%MSIGDB_C2%BIOCARTA_DEATH_PATHWAY BIOCARTA_DEATH_PATHWAY Casp6 Prmt2 Bid Tradd Casp9 Ripk1 Tnfsf10 Casp3 Fadd Bcl2 Cflar Birc3 Casp8 Dffb Tnfsf12 Nfkb1 Birc2 Dffa Gas2 Tnfrsf25 Sptan1 Nfkbia Lmna Cycs Traf2 Xiap Apaf1 Rela Chuk Map3k14 BIOCARTA_HER2_PATHWAY%MSIGDB_C2%BIOCARTA_HER2_PATHWAY BIOCARTA_HER2_PATHWAY Pik3r1 Grip1 Il6 Hras Pik3cg Raf1 Grb2 Map2k1 Mapk1 Sos1 Esr1 Erbb4 Shc1 Erbb3 Il6st Carm1 Egfr Stat3 WNT_SIGNALING%MSIGDB_C2%WNT_SIGNALING WNT_SIGNALING Wnt10a Wisp1 B2m Wnt16 T Wnt1 Apc Wnt2b Fzd1 Lef1 Gsk3b Sfrp4 Dvl1 Sfrp1 Wnt3a Nlk Fbxw11 Fzd4 Pitx2 Frzb Pygo1 Rpl13a Fbxw2 Wnt6 Fbxw4 Dixdc1 Sox17 Wnt11 Foxn1 Wnt4 Wnt3 Ccnd3 Fzd5 Fosl1 Ctbp2 Porcn Btrc Myc Ccnd1 Wnt7a Wnt7b Fshb Lrp6 Gsk3a Slc9a3r1 Wnt8a Lrp5 Ctbp1 Csnk2a1 Tcf7l1 Actb Wnt9a Tle1 Csnk1a1 Tle2 Fzd6 Jun Fzd2 Ppp2ca Ppp2r1a Wif1 Nkd1 Fgf4 Csnk1d Aes Csnk1g1 Senp2 Wnt5b Wnt5a Dkk1 Daam1 Ctnnbip1 Tcf7 Cxxc4 PID_HIF1A_PATHWAY%MSIGDB_C2%PID_HIF1A_PATHWAY PID_HIF1A_PATHWAY Cul2 Rbx1 Egln3 Egln2 Vhl Tp53 Hif1a Arnt Tceb1 Hif1an Cdkn2a Hif3a Os9 LOC103692716 PID_NECTIN_PATHWAY%MSIGDB_C2%PID_NECTIN_PATHWAY PID_NECTIN_PATHWAY Pvrl2 Cldn1 Pik3r1 Iqgap1 F11r Pdgfb Vav2 Farp2 Ctnna1 Rac1 Tln1 Crk Pip5k1c Cdh1 Src Pvrl1 Rap1b Pdgfrb Rap1a Ptprm Pvrl3 Ptk2 BIOCARTA_ERYTH_PATHWAY%MSIGDB_C2%BIOCARTA_ERYTH_PATHWAY BIOCARTA_ERYTH_PATHWAY Kitlg Flt3 Il6 Csf3 Igf1 Epo Il9 Csf2 Tgfb3 Tgfb2 Il11 Il1a Tgfb1 BIOCARTA_BCR_PATHWAY%MSIGDB_C2%BIOCARTA_BCR_PATHWAY BIOCARTA_BCR_PATHWAY Hras Mapk14 Fos Map2k1 Sos1 Syk Shc1 Cd79b Cd79al Nfatc2 Map3k1 LOC100912399 Plcg1 Nfatc4 Nfatc3 Vav1 Elk1 Ppp3ca Prkcb Ppp3cb Blnk Jun Raf1 Rac1 Grb2 Mapk8 Lyn Prkca HALLMARK_PROTEIN_SECRETION%MSIGDB_C2%HALLMARK_PROTEIN_SECRETION HALLMARK_PROTEIN_SECRETION Napa Napg Galc Copb1 Gla Rer1 Pam Rab22a Ap3b1 Ocrl Arfip1 Vamp7 Sec22b Vps45 Rab14 Cd63 Cope LOC100909548 Sgms1 Vps4b Vamp4 Dopey1 Stx7 M6pr Sod1 Krt18 Dnm1l Igf2r Lamp2 Rps6ka3 Snx2 Ykt6 Sec31a Cog2 Mapk1 Stam Ctsc Tmed2 Atp7a Ap3s1 Tpd52 Cav2 Arfgef1 Ppt1 Arfgef2 Ap2s1 Sspn Lman1 Rab9a Bnip3 Rab2a Clcn3 Ica1 Tsg101 Egfr Vamp3 Abca1 Sec24d Atp6v1h Zw10 Stx16 Stx12 Yipf6 Sh3gl2 Clk2 Clta Arcn1 Uso1 Bet1 Golga4 Anp32e Ap2m1 Cltc Ergic3 Mon2 Gosr2 Tspan8 Tmed10 Scrn1 Gbf1 Atp1a1 BIOCARTA_DNAFRAGMENT_PATHWAY%MSIGDB_C2%BIOCARTA_DNAFRAGMENT_PATHWAY BIOCARTA_DNAFRAGMENT_PATHWAY Dffb Endog Casp3 Hmgb2 Dffa BIOCARTA_IL6_PATHWAY%MSIGDB_C2%BIOCARTA_IL6_PATHWAY BIOCARTA_IL6_PATHWAY Csnk2a1 Il6 Hras Jak3 Jak1 Jun Raf1 Fos Map2k1 Grb2 Sos1 Srf Shc1 Il6st Elk1 Stat3 Ptpn11 PID_RANBP2_PATHWAY%MSIGDB_C2%PID_RANBP2_PATHWAY PID_RANBP2_PATHWAY Ran Pias1 Ranbp2 Ube2i Mdm2 Xpo1 Hdac1 Pias2 Hdac1l Hdac4 PID_ATM_PATHWAY%MSIGDB_C2%PID_ATM_PATHWAY PID_ATM_PATHWAY Bid Rad50 Fancd2 Brca1 Blm Rad17 Rbbp8 Mdm2 Fam175a Cdc25c Dclre1c Ube2n Tp53bp1 Uimc1 Ctbp1 Mre11a Smc3 Ywhab LOC100909750 Xrcc4 H2afx Chek2 Atm Kat5 Nbn Abl1 Cdc25a Smc1a Trim28 Terf2 BIOCARTA_TCAPOPTOSIS_PATHWAY%MSIGDB_C2%BIOCARTA_TCAPOPTOSIS_PATHWAY BIOCARTA_TCAPOPTOSIS_PATHWAY Cd3g Faslg Cd28 Ccr5 Cd4 Cd247 Fas Cd3d Cd3e PID_EPHA2_FWD_PATHWAY%MSIGDB_C2%PID_EPHA2_FWD_PATHWAY PID_EPHA2_FWD_PATHWAY Pik3r1 Acp1 Vav3 Vav2 Efna1 Epha2 Rac1 Grb2 Tiam1 Cbl Shc1 Src Bcar1 Arhgap35 Rhoa Pak1 Ptk2 BIOCARTA_NFKB_PATHWAY%MSIGDB_C2%BIOCARTA_NFKB_PATHWAY BIOCARTA_NFKB_PATHWAY Tradd Ripk1 Fadd Tlr4 Map3k7 Nfkbia Il1r1 Tnfrsf1a Tnfrsf1b Ikbkb Rela Chuk Map3k1 LOC100912399 Map3k14 Nfkb1 Traf6 Il1a Myd88 HALLMARK_TGF_BETA_SIGNALING%MSIGDB_C2%HALLMARK_TGF_BETA_SIGNALING HALLMARK_TGF_BETA_SIGNALING Serpine1 Bmpr2 Tgif1 Hdac1l Smad6 Ube2d3 Apc Rab31 Smad1 Furin Bmp2 Nog Rhoa Slc20a1 Tgfb1 Ltbp2 Hdac1 LOC100912163 Arid4b Klf10 Id3 Smad3 Cdk9 Fnta Trim33 Map3k7 Skil Pmepa1 Ifngr2 Acvr1 Smad7 Fkbp1a Tjp1 Id1 Junb Bcar3 Cdh1 Ppp1ca Ppp1r15a Xiap Ncor2 Hipk2 Tgfbr1 Id2 Smurf1 Wwtr1 Sptbn1 PID_RET_PATHWAY%MSIGDB_C2%PID_RET_PATHWAY PID_RET_PATHWAY Pxn Hras Prkaca Gab1 Irs2 Sos1 Gdnf Creb1 Shc1 Rasa1 Pdlim7 Rhoa Ptpn11 Ptk2 Nck1 Pik3r1 Jun Rac1 Grb2 Dok6 Mapk1 Shank3 Irs1 Crk Dok4 Mapk8 Frs2 Src Bcar1 Grb7 Rap1a Prkca Ret Grb10 Dok1 BIOCARTA_AMI_PATHWAY%MSIGDB_C2%BIOCARTA_AMI_PATHWAY BIOCARTA_AMI_PATHWAY Serpinc1 Proc F2r Plat Tfpi F7 Col4a2 Ahsp Col4a3 Col4a1 Col4a5 LOC100911572 Pros1 F2 Fga Plg Fgg Fgb F10 HALLMARK_MTORC1_SIGNALING%MSIGDB_C2%HALLMARK_MTORC1_SIGNALING HALLMARK_MTORC1_SIGNALING Me1 Tmem97 Sqle Cyp51 Cyb5b Pdap1 Hspa4 Asns Slc7a11 Hmgcr Scd1 Slc2a1 Ebp Qdpr Ykt6 Cth Stard4 Rrp9 Slc1a5 Tuba4a Tm7sf2 Ldlr Sc5d Fam129a Nfil3 Hspd1 Hmgcs1 Skap2 G6pc Mcm2 Dhcr7 Tubg1 Got1 Ppp1r15a Nmt1 Tcea1 Psmd14 Ppia Rpn1 Stip1 Itgb2 Sqstm1 Trib3 Lgmn Gpi Mthfd2 Egln3 Ak4 Pgk1 Add3 Ccnf Ssr1 Calr Tes Idh1 Slc1a4 Ung Xbp1 Psma3 Elovl5 Hsp90b1 Lta4h Actr3 Bub1 Rit1 Ccng1 Aurka Actr2 Btg2 Cdc25a Adipor2 Cfp Ddx39a Prdx1 Rpa1 Ddit3 Gla Bhlhe40 Acly Aldoa Ero1l Eif2s2 Cdkn1a LOC100909548 Fads1 Psmc2 Serpinh1 Fdxr Rdh11 Gsk3b Dapp1 M6pr Immt Elovl6 Pdk1 Eno1 Rrm2 Wars Idi1 Psat1 Plk1 Hspa9 Stc1 P4ha1 Slc37a4 Tbk1 Slc2a3 Sec11a Slc7a5 Psmb5 Hspa5 Serp1 Nfkbib Plod2 Psmd12 Pgm1 Ctsc Ifi30 Cxcr4 Nfyc Vldlr Dhcr24 Dhfr Atp2a2 Txnrd1 Ddit4 Pnp Gtf2h1 Etf1 Acsl3 Rab1a Gga2 Mllt11 Nufip1 Sdf2l1 Psma4 Shmt2 Ube2d3 Pitpnb Cacybp Gsr Eprs Phgdh Hk2 Fkbp2 Hmbs Tomm40 Uchl5 Srd5a1 Cct6a Atp5g1 Slc9a3r1 Atp6v1d Mcm4 Pno1 Igfbp5 Slc6a6 Psmd13 Psmg1 Abcf2 Psph Sar1a Mthfd2l Polr3g Sord Nup205 Eef1e1 Ufm1 Pik3r3 Psmc4 Coro1a Tfrc Psmc6 Fgl2 Bcat1 Insig1 Nampt Glrx Uso1 Pfkl Gmps Canx Gclc BIOCARTA_STRESS_PATHWAY%MSIGDB_C2%BIOCARTA_STRESS_PATHWAY BIOCARTA_STRESS_PATHWAY Tradd Ripk1 Atf1 Map2k4 Mapk14 Lta Jun Casp2 Cradd Nfkbia Tnfrsf1a Tank Map2k6 Mapk8 Ikbkb Traf2 Map4k2 Rela Chuk Map3k1 LOC100912399 Map3k14 Nfkb1 PID_HDAC_CLASSII_PATHWAY%MSIGDB_C2%PID_HDAC_CLASSII_PATHWAY PID_HDAC_CLASSII_PATHWAY LOC100910438 Gata1 Tubb2a Camk4 Srf Mef2c Ran Esr1 Ywhae LOC103692716 Ube2i Xpo1 LOC100911167 Hdac3 Ywhab Rfxank Adrbk1 Hdac6 Ncor2 Bcl6 LOC100360129 Ankra2 Hdac11 Gnb1 Hdac10 Ranbp2 Gata2 Hdac4 PID_ALK1_PATHWAY%MSIGDB_C2%PID_ALK1_PATHWAY PID_ALK1_PATHWAY Csnk2b Acvr2b Bmpr2 Mapk1 Fkbp1a Acvr1 Smad7 Id1 Tgfb3 Acvrl1 Ppp1ca Smad5 Arrb2 Smad1 Tgfbr2 Acvr2a Tgfbr1 Tgfb1 Inhba Gdf2 BIOCARTA_INSULIN_PATHWAY%MSIGDB_C2%BIOCARTA_INSULIN_PATHWAY BIOCARTA_INSULIN_PATHWAY Csnk2a1 Pik3r1 Hras Ins2 Insr Pik3cg Raf1 Jun Fos Map2k1 Grb2 Sos1 Irs1 Srf Mapk8 Shc1 Rasa1 Slc2a4 Elk1 Ptpn11 NABA_PROTEOGLYCANS%MSIGDB_C2%NABA_PROTEOGLYCANS NABA_PROTEOGLYCANS Epyc Optc LOC102550316 Omd Chad Nyx Prg2 Ncan Prelp Prg3 Prg4 LOC100910891 Kera Spock3 Podnl1 Rangap1 LOC100911378 Dcn Lum Esm1 Ogn Srgn Vcan Bcan Aspn Fmod Hapln3 Impg1 Hapln1 Impg2 Hapln4 Hapln2 LOC100910284 PID_AR_TF_PATHWAY%MSIGDB_C2%PID_AR_TF_PATHWAY PID_AR_TF_PATHWAY Smarca2 Rxra Smarce1 Cebpa Mapk14 Foxo1 Mdm2 Smarcc1 Hdac1l Gsk3b LOC103692716 Dnaja1 Carm1 Rxrg Tmprss2 Rxrb Hdac1 Ar Nr2c2 Nr2c1 Nr0b1 Appbp2 Rchy1 Map2k4 Egr1 Ncoa1 Jun Ncoa2 Spdef Ehmt2 Mapk8 Pde9a Map2k6 Zmiz2 Kat5 Crebbp Src Hoxb13 Senp1 Trim24 Kat7 Pou2f1 Gata2 Pkn1 BIOCARTA_UCALPAIN_PATHWAY%MSIGDB_C2%BIOCARTA_UCALPAIN_PATHWAY BIOCARTA_UCALPAIN_PATHWAY Pxn Acta1 Sptan1 Itgb1 Rac1 Tln1 Ezr Capn1 Actn1 Actn2 Src Actn3 LOC100911363 LOC100912380 Capns1 Rhoa Ptk2 PID_HEDGEHOG_GLI_PATHWAY%MSIGDB_C2%PID_HEDGEHOG_GLI_PATHWAY PID_HEDGEHOG_GLI_PATHWAY Lgals3 Foxa2 Pias1 Sin3a Prkaca Map2k1 Hdac1l Hdac2 Spop Gsk3b Xpo1 Hdac1 Akt1 Gnai1 Gli1 Gli2 Ptch1 Shh Prkcd Csnk1a1 Fbxw11 Sap18 RGD1561590 Rbbp7 Smo Sufu Ift88 Csnk1d Csnk1g1 Gnai3 Arrb2 Gnao1 Crebbp Gnai2 Csnk1g2 Gnaz Sspo Gnb1 Kif3a Stk36 Csnk1g3 Rab23 Csnk1e Mtss1 PID_REELIN_PATHWAY%MSIGDB_C2%PID_REELIN_PATHWAY PID_REELIN_PATHWAY LOC100911248 Itga3 Crkl Itgb1 Grin2b Mapk8ip1 Dab1 Cdk5 Gsk3b Reln Lrp8 Lrpap1 Map1b Akt1 Pik3r1 Nck2 Pafah1b1 Map3k11 Fyn Arhgef2 Map2k7 Cdk5r1 Cbl Mapk8 Rap1a Vldlr PID_TCR_PATHWAY%MSIGDB_C2%PID_TCR_PATHWAY PID_TCR_PATHWAY Flna Rasgrp1 Ptpn6 Orai1 Rassf5 Stim1 Cd28 Sh3bp2 Fyb Trpv6 Sla2 Plcg1 Akt1 Zap70 Pten Csk Ptprc Map3k8 Lcp2 Nras Ikbkb Chuk Prkca Cd86 Map3k14 Rasgrp2 Traf6 RT1-Db1 Hras Cd4 Gab2 Pdpk1 Sos1 RT1-Da Shc1 Map4k1 Kras Vav1 Lat Inpp5d Bcl10 Prkcq Ptpn11 Lck Nck1 Prkcb Cd80 Fyn Grb2 Cbl Dbnl Cd3g Stk39 Rap1a Itk Cd247 Cd3d Cd3e BIOCARTA_CTLA4_PATHWAY%MSIGDB_C2%BIOCARTA_CTLA4_PATHWAY BIOCARTA_CTLA4_PATHWAY Pik3r1 RT1-Db1 Cd28 Cd80 Icoslg Grb2 RT1-Da Il2 Cd3g Itk Cd86 Cd247 Cd3d Ptpn11 Lck Cd3e PID_TOLL_ENDOGENOUS_PATHWAY%MSIGDB_C2%PID_TOLL_ENDOGENOUS_PATHWAY PID_TOLL_ENDOGENOUS_PATHWAY Sftpa1 Tlr2 Cd14 Tlr4 Tirap Hspd1 S100a9 Vcan S100a8 Ikbkb Irak2 Tlr3 Tlr6 Chuk Irak4 Rhoa Myd88 BIOCARTA_FMLP_PATHWAY%MSIGDB_C2%BIOCARTA_FMLP_PATHWAY BIOCARTA_FMLP_PATHWAY Hras Mapk14 Map2k1 Map2k2 Camk1g Camk1 Nfatc2 Map3k1 LOC100912399 Nfatc4 Nfkb1 Nfatc3 Pak1 Elk1 Ppp3ca Ncf2 Fpr1 Ppp3cb Plcb1 Raf1 Nfkbia Rac1 Mapk1 Gna15 Map2k6 Gngt1 Pik3c2g Rela Gnb1 BIOCARTA_NEUROTRANSMITTERS_PATHWAY%MSIGDB_C2%BIOCARTA_NEUROTRANSMITTERS_PATHWAY BIOCARTA_NEUROTRANSMITTERS_PATHWAY Gad1 Th Dbh Tph1 Hdc BIOCARTA_FAS_PATHWAY%MSIGDB_C2%BIOCARTA_FAS_PATHWAY BIOCARTA_FAS_PATHWAY Casp6 Casp3 Fadd Ripk2 Cflar Parp1 Fas Casp8 Dffb Map3k1 LOC100912399 Ptpn13 Pak1 Dffa Faf1 Daxx Rb1 Pak2 Map2k4 Lmnb1 Jun Sptan1 Map3k7 Arhgdib Lmna Prkdc Lmnb2 Mapk8 Faslg BIOCARTA_HSP27_PATHWAY%MSIGDB_C2%BIOCARTA_HSP27_PATHWAY BIOCARTA_HSP27_PATHWAY Casp9 Daxx Casp3 Hspb1 Bcl2 Acta1 Fas Cycs Faslg Apaf1 Mapkapk2 Il1a Mapkapk3 Hspb2 PID_CD8_TCR_PATHWAY%MSIGDB_C2%PID_CD8_TCR_PATHWAY PID_CD8_TCR_PATHWAY Rasgrp1 Cd8a Hras Ptpn6 Orai1 Rassf5 Stim1 Cd28 B2m Trpv6 Pdpk1 Sos1 Cd8b Shc1 Plcg1 Kras Vav1 Lat Bcl10 Prkcq Akt1 Lck Prkcb Zap70 Cd80 Fyn Grb2 Csk Ptprc Cbl Lcp2 Map3k8 Nras Ikbkb Cd3g Rap1a Chuk Prkca Cd86 Rasgrp2 Cd247 Map3k14 Traf6 Cd3d Cd3e ST_P38_MAPK_PATHWAY%MSIGDB_C2%ST_P38_MAPK_PATHWAY ST_P38_MAPK_PATHWAY Mapk12 Mapk13 Mapk11 Mapk14 Mapkapk5 Il1r1 Dusp1 Srf Creb1 Nfkb1 Mapkapk2 Creb5 Creb3 Elk1 Akt1 Nr2c2 Map3k4 Atf1 Dusp10 Myef2 Map2k4 Hspb1 Map3k10 Mknk2 Map3k7 Mknk1 Mapk1 Tab2 Gadd45a Map2k6 Eef2k Traf6 PID_ARF6_DOWNSTREAM_PATHWAY%MSIGDB_C2%PID_ARF6_DOWNSTREAM_PATHWAY PID_ARF6_DOWNSTREAM_PATHWAY Pld2 Pld1 Arf6 Rab11a Kalrn Rhoa Rac1 Mapk1 Tiam1 Nme1 PID_AJDISS_2PATHWAY%MSIGDB_C2%PID_AJDISS_2PATHWAY PID_AJDISS_2PATHWAY Casp3 Hras Ptpn6 Cables1 Slit1 Ntrk2 Mmp7 Zbtb33 Dsp Gdnf Bdnf LOC100910807 Robo1 Rin2 Cbll1 Cdh2 Egfr Dnm2 Snx1 Iqgap1 Igf1r Jup LOC100909750 Ptpn1 Ctnna1 Fyn Rac1 Igf2 Tiam1 Nme1 Cdh1 Ctnnd1 Crebbp Src Abl1 Gna12 Gna13 Arf6 Rab7a Ret PID_MET_PATHWAY%MSIGDB_C2%PID_MET_PATHWAY PID_MET_PATHWAY LOC100911248 Crkl Gab1 Apc Snai1 Rin2 F2rl2 Plcg1 Rhoa Akt2 Bad Prkcz Akt1 Raf1 Rac1 Mapk1 Mapk8 Arhgef4 Bcar1 Hgf Mlst8 Kpnb1 Akt1s1 Ranbp10 Mtor Pxn Hras Eif4ebp1 Ets1 Gab2 Pdpk1 Map2k1 Map2k2 Sos1 Rptor Pak4 Shc1 Ptprj Map3k1 LOC100912399 Pak1 Inpp5d Ptpn11 Ptk2 Nck1 Pik3r1 Map2k4 Pak2 Nck2 Ptpn1 Egr1 Pard6a Sh3kbp1 Ctnna1 Jun Grb2 Muc20 Ptpn2 Prkci Crk Cbl Cdh1 Src Sh3gl2 Rap1b Arf6 Rap1a PID_PRL_SIGNALING_EVENTS_PATHWAY%MSIGDB_C2%PID_PRL_SIGNALING_EVENTS_PATHWAY PID_PRL_SIGNALING_EVENTS_PATHWAY Cdk2 Egr1 Rhoc Itgb1 Atf5 Rac1 Rabggta Ptp4a3 Mapk1 Rabggtb Ptp4a1 Cdkn1a Ccna2 Agt Src Bcar1 Rock1 Ccne1 Rhoa HALLMARK_OXIDATIVE_PHOSPHORYLATION%MSIGDB_C2%HALLMARK_OXIDATIVE_PHOSPHORYLATION HALLMARK_OXIDATIVE_PHOSPHORYLATION Echs1 Got2 mrpl11 Vdac1 Eci1 Pdk4 Idh3B Atp6v1f Cyb5a Vdac3 Pdhb Atp6v1c1 Acadm Fh Dld Acaa2 Decr1 Cox8a Slc25a3 Suclg1 Tomm70a Hsd17b10 Phb2 Por Ndufb7 Ndufab1 Hadhb Cycs Acadvl Sdhd Cyc1 Sdha Mdh1 Sdhc Sdhb Mdh2 Dlst Ndufa5 Gpi Ldhb Idh1 Idh2 Atp5j Cpt1a Lrpprc Sucla2 Iscu Atp6v1g1 Atp6v1h Timm10 Oxa1l Pmpca Atp5f1 Ndufa7l Timm13 Etfa Mtx2 Bdh2 Idh3g Cyb5r3 Hccs LOC100911485 Atp5b Cox4i1 Atp5c1 Grpel1 Atp5d Bckdha Mrpl34 Atp5o Mrpl35 Cox7a2l Ndufv2 Ech1 Ndufs8 Ndufs6 Atp1b1 LOC686442 Ndufs7 Ndufs4 Mtrr Dlat Atp5g3 Ndufs1 Cox5b Vdac2 LOC100911779 Mfn2 Rhot2 Acadsb Timm17a LOC100910689 Retsat Uqcrq Atp6v1e1 Mpc1 Pdp1 Immt Ndufv1 Etfb Timm8b Phyh Atp5i LOC100361144 Tcirg1 Idh3a Opa1 Nqo2 Fdx1 Atp5l Atp6v0c Mrps15 Maob Mrps12 Hspa9 Mrps11 LOC100912599 Ndufb6 Ndufb8 Uqcr11 Ndufb3 Ndufa2 Oat Hadha Ndufa4 Slc25a4 Afg3l2 Mrpl15 Atp5j2 Cox15 Slc25a11 Cox6a1 Uqcrfs1 Mrps30 Uqcrc1 Ndufc2 Taf3 Atp5g2 Uqcrc2 Atp6v0e1 Timm9 LOC679739 Ndufs3 Ndufb2 Slc25a20 Ndufb5 Acat1 Tomm22 Cox7a2 Pdhx Etfdh Bax Mgst3 Ndufa6 Cox5a Aifm1 Ndufa7 Ndufa8 Prdx3 Ogdh Aco2 LOC683884 Atp5g1 Polr2f Atp6v1d Htra2 Aldh6a1 Cox7b Cs Atp6ap1 LOC100912008 Slc25a5 Ndufa1 Nnt Cox17 Ndufs2 Gpx4 Atp5a1 BIOCARTA_PTEN_PATHWAY%MSIGDB_C2%BIOCARTA_PTEN_PATHWAY BIOCARTA_PTEN_PATHWAY Pik3r1 Itgb1 Pten Pdpk1 Mapk1 Grb2 Sos1 Foxo3 Pdk2 Cdkn1b Faslg Shc1 Bcar1 Ilk Akt1 Ptk2 BIOCARTA_SPPA_PATHWAY%MSIGDB_C2%BIOCARTA_SPPA_PATHWAY BIOCARTA_SPPA_PATHWAY Gnai1 Hras Prkcb F2r Raf1 Itgb1 Plcb1 Map2k1 Mapk1 Syk Gngt1 Src Tbxas1 Ptgs1 Prkca Gnb1 F2 Pla2g4a Ptk2 PID_LPA4_PATHWAY%MSIGDB_C2%PID_LPA4_PATHWAY PID_LPA4_PATHWAY Adcy3 Adcy5 Creb1 Adcy4 Lpar4 Adcy7 Prkaca Adcy6 Adcy8 Gnal Rps6ka5 ST_T_CELL_SIGNAL_TRANSDUCTION%MSIGDB_C2%ST_T_CELL_SIGNAL_TRANSDUCTION ST_T_CELL_SIGNAL_TRANSDUCTION Rasgrp1 Prdx1 Cd28 Sos1 Pak3 Pak4 Itpka Itpkb Ephb2 Plcg1 Nfkb2 Nfkb1 Pak1 Vav1 Lat Tonsl Pak6 Lck Pak7 Nck1 Pak2 Dtymk Zap70 Nfkbil1 Dag1 Raf1 Nfkbia Nfat5 Grb2 Mapk1 Nfkbie Csk Nfkbib Ptprc Cbl Lcp2 Itk Rasgrp4 Rasgrp2 Rasgrp3 Cd3d PID_FAK_PATHWAY%MSIGDB_C2%PID_FAK_PATHWAY PID_FAK_PATHWAY Git2 Plcg1 Rhoa Dock1 Raf1 Rac1 Mapk1 Yes1 Rras Mapk8 Arhgef7 Bcar1 Itga5 Grb7 Arhgef11 LOC100909609 Bmx Pxn Ets1 Ccnd1 Itgb1 Mapk8ip3 Map2k1 Tln1 Sos1 Rock2 Rasa1 Arhgap35 Pak1 Arhgef28 Ptk2 Arhgap26 Nck1 Pik3r1 Map2k4 Mapk9 Nck2 Acta1 Jun Fyn Grb2 Actn1 Crk Src Mmp14 Rap1b Vcl Rap1a Asap1 Capn2 BIOCARTA_BARRESTIN_PATHWAY%MSIGDB_C2%BIOCARTA_BARRESTIN_PATHWAY BIOCARTA_BARRESTIN_PATHWAY Gngt1 Ppara Dnm1 Arrb1 Plcb1 Gnb1 Ap2m1 Ap2a1 PID_P38_GAMMA_DELTA_PATHWAY%MSIGDB_C2%PID_P38_GAMMA_DELTA_PATHWAY PID_P38_GAMMA_DELTA_PATHWAY Mapk12 Stmn1 Map2k6 Mapk13 Eef2k Snta1 Ccnd1 Pkn1 PID_PI3K_PLC_TRK_PATHWAY%MSIGDB_C2%PID_PI3K_PLC_TRK_PATHWAY PID_PI3K_PLC_TRK_PATHWAY Hras Ccnd1 Camk4 Gab1 Pdpk1 Sos1 Ntrk1 Ngf Camk2a Creb1 Shc1 Gsk3b Stat5a Ywhae Sfn Plcg1 Kras Bad Akt1 Trpc3 Pik3r1 Ywhab Prkcd Egr1 Trpv1 Ywhah Grb2 Ywhag Nras Foxo3 Ywhaz Src BIOCARTA_TCYTOTOXIC_PATHWAY%MSIGDB_C2%BIOCARTA_TCYTOTOXIC_PATHWAY BIOCARTA_TCYTOTOXIC_PATHWAY Cd8a Cd3g Cd28 Cd2 Itgb2 Icam1 Cd247 Thy1 Itgal Cd3d Ptprc Cd3e PID_PTP1B_PATHWAY%MSIGDB_C2%PID_PTP1B_PATHWAY PID_PTP1B_PATHWAY Nox4 Ybx1 LOC103693683 Pdgfb Trpv6 Socs3 Stat5b Fer Shc1 Stat5a Cdh2 Rhoa Leprot Egfr Lat Stat3 Itga2b Akt1 Lck Pik3r1 Spry2 Fgr Ins2 Lepr Insr Ptpn1 Prl Lep Hck Fyn Blk Grb2 Csn2 Csk Capn1 Yes1 Irs1 Crk Lyn Src Bcar1 Pdgfrb Dok1 Csf1 Txn1 Csf1r SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES%MSIGDB_C2%SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Cyth3 Gab1 Syk Itpr1 Itpr3 Ppp1r13b Prex1 Dapp1 Nr0b2 Pdk1 Rps6ka3 Akt2 Vav1 Akt3 Sag Akt1 Flot1 Pik3r5 Flot2 Rps6ka2 Nr4a3 Pten Cd19 Pitx2 Ptprc Foxo3 Rps6kb1 Lyn Cdkn2a Rps6ka1 BIOCARTA_PML_PATHWAY%MSIGDB_C2%BIOCARTA_PML_PATHWAY BIOCARTA_PML_PATHWAY Pram1 Daxx Rb1 Hras Pml Tp53 Fas Tnfrsf1a Tnfrsf1b Crebbp Faslg Pax3 Rara ST_INTERLEUKIN_13_PATHWAY%MSIGDB_C2%ST_INTERLEUKIN_13_PATHWAY ST_INTERLEUKIN_13_PATHWAY Il13ra1 Il4r Jak1 Il13 Il13ra2 LOC100360218 BIOCARTA_RACCYCD_PATHWAY%MSIGDB_C2%BIOCARTA_RACCYCD_PATHWAY BIOCARTA_RACCYCD_PATHWAY Cdk2 Rb1 Pik3r1 Hras Raf1 Ccnd1 Rac1 Nfkbia Mapk1 E2f1 Cdkn1a Cdk4 Ikbkb Cdkn1b Rela Chuk Ccne1 Nfkb1 Rhoa Pak1 Cdk6 Akt1 BIOCARTA_ETS_PATHWAY%MSIGDB_C2%BIOCARTA_ETS_PATHWAY BIOCARTA_ETS_PATHWAY Hras Etv3 Ets1 Ddx20 Rbl1 Sin3a Jun Fos Ets2 E2f1 Hdac2 Ncor2 Rbl2 Csf1 Csf1r PID_LKB1_PATHWAY%MSIGDB_C2%PID_LKB1_PATHWAY PID_LKB1_PATHWAY Smarcd3 Mtor Mark4 Map2 Etv4 Sik1 Prkaca Myc Tp53 Ezr Cdc37 Rptor Esr1 Creb1 Gsk3b Ywhae Sfn LOC103692716 Prkab1 Ywhab Prkaa1 Psen2 Cab39 Prkaa2 Mark2 Ywhah Ywhag Stk11ip Ywhaz Stk26 Brsk1 Strada Stradb Stk11 Mlst8 Tsc1 Tsc2 Akt1s1 Ctsd BIOCARTA_HIVNEF_PATHWAY%MSIGDB_C2%BIOCARTA_HIVNEF_PATHWAY BIOCARTA_HIVNEF_PATHWAY Tradd Ripk1 Fadd Cflar Casp8 Numa1 Nfkb1 Gsn Rb1 LOC100361457 Prkcd Sptan1 Actg1 Cradd Nfkbia Prkdc Mapk8 Cycs Xiap Traf2 Apaf1 Rela Chuk Map3k14 Casp6 Bid Casp9 Casp3 Bcl2 Psen1 Parp1 Birc3 Fas Mdm2 Bag4 Tnfrsf1b Dffb Rasa1 Map3k1 LOC100912399 Birc2 Dffa Ptk2 Daxx Pak2 Psen2 Lmnb1 Casp2 Arhgdib Lmna Map2k7 Tnfrsf1a Lmnb2 Faslg PID_SYNDECAN_3_PATHWAY%MSIGDB_C2%PID_SYNDECAN_3_PATHWAY PID_SYNDECAN_3_PATHWAY Ptn Psenen Psen1 Cttn Fyn Ncstn Sdc3 LOC102550316 LOC100911293 Aph1b Src Ncan Agrp Mc4r Pomc Egfr PID_MYC_PATHWAY%MSIGDB_C2%PID_MYC_PATHWAY PID_MYC_PATHWAY Skp2 Ruvbl2 Ppp2r5a Pml Pak2 Max Myc Hbp1 Pin1 Ppp2ca LOC364561 Ruvbl1 Kat5 Gsk3b Cdkn2a Actl6a Kat2a Zbtb17 Taf9 Supt7l BIOCARTA_HIF_PATHWAY%MSIGDB_C2%BIOCARTA_HIF_PATHWAY BIOCARTA_HIF_PATHWAY Vegfa Creb1 Asph P4hb Epo Jun Vhl LOC103692716 Hif1a Edn1 Arnt Nos3 BIOCARTA_COMP_PATHWAY%MSIGDB_C2%BIOCARTA_COMP_PATHWAY BIOCARTA_COMP_PATHWAY C1qa C1qb Mbl2 C6 C1r C1qc C4a C8a C9 C3 Cfd C2 Masp2 LOC100911854 C1s BIOCARTA_MET_PATHWAY%MSIGDB_C2%BIOCARTA_MET_PATHWAY BIOCARTA_MET_PATHWAY Pxn Hras LOC100911248 Itgb1 Crkl Fos Gab1 Map2k1 Sos1 Map2k2 Map4k1 Rasa1 Ptk2b Pak1 Elk1 Stat3 Ptpn11 Ptk2 Pik3r1 Dock1 Pik3cg Acta1 Jun Pten Raf1 Grb2 Mapk1 Crk Mapk8 Src Rap1b Rap1a Hgf LOC100909609 PID_CIRCADIAN_PATHWAY%MSIGDB_C2%PID_CIRCADIAN_PATHWAY PID_CIRCADIAN_PATHWAY Atr Bhlhe40 Stt3a Cry1 Nono Timeless Per1 Npas2 Wdr5 LOC100911602 Arntl Nr1d1 Clock Cry2 Per2 Csnk1e ST_FAS_SIGNALING_PATHWAY%MSIGDB_C2%ST_FAS_SIGNALING_PATHWAY ST_FAS_SIGNALING_PATHWAY Smpd1 Ripk1 Diablo Cad Fadd Cd7 Casp8 Pfn1 Alg2 Cdk2ap1 Ephb2 Nfkb2 Nfkb1 Ptpn13 Mapk10 Tonsl Faf1 Ncs1 Bak1 Hspb1 Nfkbil1 Nfkbia Nfat5 Tpx2 Nfkbie Mapk1 Nfkbib Ralbp1 Mapk8 Traf2 Xiap Casp8ap2 Rock1 Il1a Tufm Dedd Casp3 Bax Parp1 Mapk8ip2 Tp53 Mapk8ip3 Fas Mapk8ip1 Ezr Map3k1 Nr0b2 LOC100912399 Egfr Dffa Daxx Map2k4 Mapk9 Csnk1a1 Map2k7 Bfar Pfn2 LOC100909840 HALLMARK_E2F_TARGETS%MSIGDB_C2%HALLMARK_E2F_TARGETS HALLMARK_E2F_TARGETS Mad2l1 Syncrip Ccp110 Tmpo Espl1 Mcm7 Ssrp1 Nap1l1 Smc4 Rad51c Pold2 Cdkn1b Depdc1 Ilf3 Hells LOC100911660 Srsf1 Nop56 Bard1 Nup153 Ctcf Kif4a Shmt1 Cdkn3 Mre11a Suv39h1 Asf1b Mcm3 Tubb5 Mcm5 Dck Spc25 Dlgap5 Mcm6 Asf1a Prkdc Pcna Wee1 Mcm2 Nudt21 Cdk4 Chek2 Nolc1 Mybl2 Timeless Tubg1 Rpa3 Cks2 Cdk1 Mki67 Kif2c Cdc20 Lig1 Mms22l Snrpb Racgap1 Pnn Mthfd2 Pttg1 Melk Gins1 Rnaseh2a Gins3 E2f8 Ube2s Pan2 Lyar Myc Donson Tp53 Cdca3 Orc6 Slbp Stt3a Pms2 Psmc3ip Cit Kif18b Dctpp1 Smc6 Cdkn2c Pop7 Ing3 Hmmr Psip1 Hn1 Nup107 Rab24 Trip13 Stag1 Paics Cenpm Ubr7 Kpna2 Eed Ung Rqcd1 Ppp1r8 Ezh2 Lsm8 Dscc1 Xpo1 Phf5a Tra2b Luc7l3 Spag5 Cdca8 Smc3 Ncapd2 Lmnb1 Aurka Hnrpd Rbbp7 H2afx H2afz Aurkb Tacc3 Nme1 Srsf2 Suv39h1l1 Zw10 Nbn Cdc25b Cdc25a Ipo7 Ppm1d Smc1a Gins4 Anp32e Cenpe Atad2 Cse1l Ddx39a Rad21 Rpa1 Rad1 Rad50 Hmgb2 Spc24 Brca1 Bub1b Cdkn1a Ak2 Pa2g4 Rfc3 Rfc2 Usp1 Ccne1 Rpa2 Ube2t Gspt1 Dnmt1 Rrm2 Plk4 RGD1565297 Cks1l Prim2 Hus1 Plk1 Ranbp1 Brca2 Xrcc6 LOC100362620 Pola2 Msh2 Hmgb3 Stmn1 Cbx5 Cdkn2a Nasp Pole Kif22 Mlh1 Hmga1 Prdx4 Ctps1 Eif2s1 Pole4 Ran Pds5b Cks1b Mcm4 Dek Orc2 Nup205 Tfrc Pold1 Rfc1 BIOCARTA_GLEEVEC_PATHWAY%MSIGDB_C2%BIOCARTA_GLEEVEC_PATHWAY BIOCARTA_GLEEVEC_PATHWAY Pik3r1 Hras Map2k4 LOC100911248 Pik3cg Myc Raf1 Jun Fos Crkl Grb2 Map2k1 Sos1 Stat5b Mapk8 Stat5a Map3k1 LOC100912399 Stat1 Bad Akt1 PID_NFAT_TFPATHWAY%MSIGDB_C2%PID_NFAT_TFPATHWAY PID_NFAT_TFPATHWAY Il4 Tbx21 Il5 Gata3 Dgka Casp3 Fos Csf2 Cd40lg Nfatc2 Egr2 Egr3 Nfatc3 Cblb Prkcq Egr4 Foxp3 Tle4 Maf Egr1 Ptpn1 Ptgs2 Jun E2f1 Cdk4 Junb Il2 Faslg Pparg Slc3a2 Il2ra Batf3 Ifng Pou2f1 Fosl1 BIOCARTA_BARR_MAPK_PATHWAY%MSIGDB_C2%BIOCARTA_BARR_MAPK_PATHWAY BIOCARTA_BARR_MAPK_PATHWAY Gngt1 Dnm1 Arrb1 Plcb1 Raf1 Gnb1 Mapk1 Map2k1 Map2k2 BIOCARTA_TID_PATHWAY%MSIGDB_C2%BIOCARTA_TID_PATHWAY BIOCARTA_TID_PATHWAY Hspa1a Hspa1b Rb1 Ush1c Tp53 Nfkbia Ifngr2 Tnfrsf1a Ifngr1 Tnfrsf1b Ikbkb Wt1 Rela Ifng Nfkb1 Dnaja3 Lin7a PID_TCR_RAS_PATHWAY%MSIGDB_C2%PID_TCR_RAS_PATHWAY PID_TCR_RAS_PATHWAY Hras Prkcb Prkca Raf1 Fos Ptpn7 Kras Mapk1 Map2k1 Elk1 Nras Map3k8 BIOCARTA_SALMONELLA_PATHWAY%MSIGDB_C2%BIOCARTA_SALMONELLA_PATHWAY BIOCARTA_SALMONELLA_PATHWAY Actr3 Arpc4 Arpc5 Wasf1 Acta1 Arpc3 Rac1 Arpc2 Arpc1b Actr2 BIOCARTA_FCER1_PATHWAY%MSIGDB_C2%BIOCARTA_FCER1_PATHWAY BIOCARTA_FCER1_PATHWAY Hras Fos Map2k1 Sos1 Syk Shc1 Nfatc2 Map3k1 LOC100912399 Plcg1 Nfatc4 Nfatc3 Pla2g4a Vav1 Elk1 Ppp3ca Fcer1a Pik3r1 Pak2 Map2k4 Prkcb Ppp3cb Pik3cg Jun Raf1 Map2k7 Grb2 Mapk1 Mapk8 Lyn BIOCARTA_DC_PATHWAY%MSIGDB_C2%BIOCARTA_DC_PATHWAY BIOCARTA_DC_PATHWAY Tlr2 Il4 Anpep Il5 Itgax Tlr7 Cd40 Il10 Ifnb1 Tlr4 Il13 Cd2 Cd7 Csf2 Cd5 LOC100911215 Il12a Ifng Il12b FANCONI ANEMIA PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FANCONI ANEMIA PATHWAY Fanconi anemia pathway Rad17 Usp1 Fancd2 Brca1 Stt3a Ube2t Wdr48 Rmi1 Topbp1 Fancl Btrc Atrip Fanca Fancf Fancc Fancb Rfc5 Palb2 Fance RGD1306926 RGD1564719 Rfc2 Rfc4 Rfc3 Mre11a Nbn Fbxw11 Atr Brca2 Blm H2afx Hus1 Atm Rad50 Rad1 Hes1 Fan1 Rpa1 Rpa2 IL8-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL8-MEDIATED SIGNALING EVENTS IL8-mediated signaling events FOXA2 AND FOXA3 TRANSCRIPTION FACTOR NETWORKS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXA2 AND FOXA3 TRANSCRIPTION FACTOR NETWORKS FOXA2 and FOXA3 transcription factor networks Hnf4a Hadh Cpt1c Ttr Nkx2-1 Cpt1b Kcnj11 Foxa1 Igfbp1 Cebpa Cpt1a Bdh1 Hmgcs1 Dlk1 Abcc8 Tfrc Tat Aldob Sp1 Pck1 Ucp2 Afp Acadm Acadvl F2 Alb Akt1 Foxa2 Foxa3 Pklr Nf1 Creb1 G6pc Hnf1a Slc2a2 Ins2 IL5-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL5-MEDIATED SIGNALING EVENTS IL5-mediated signaling events Cish Sdcbp Pik3r1 Stat5a Lyn Grb2 Ptpn11 Il5ra Csf2rb Stat5b Il5 Pim1 SYNDECAN-4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-4-MEDIATED SIGNALING EVENTS Syndecan-4-mediated signaling events Mdk Itga5 F2 Cxcl12 Rac1 Sdc4 Tfpi Prkca Lama1 Plg Fn1 Fgf6 Fgf2 Nudt16l1 Ptk2 Fgfr1 Mmp9 Ccl5 Adam12 Sdcbp Gipc1 Rhoa Cxcr4 Itgb1 Actn1 Prkcd Dnm2 BCR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BCR SIGNALING PATHWAY BCR signaling pathway Mapk1 Rac1 Mapk8 Pten Csnk2a1 Raf1 Fos Dok1 Nfkb1 Jun Bcl10 Chuk Ppp3ca Shc1 Ppp3cb Map3k7 Ptprc Blnk Fcgr2b Rela Vav2 Bcl2a1 Cd22 Ikbkb Mapk14 Ets1 Syk Csk Camk2g Cd19 Cd79al Akt1 Cd79b Map2k1 Pik3r1 Pdpk1 Cd72 Rasa1 Ptpn6 Hras Elk1 Dapp1 Lyn LOC100912399 Grb2 Traf6 Map3k1 Nfkbia Sos1 Nfkbib Map4k1 AURORA B SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AURORA B SIGNALING Aurora B signaling Klhl9 Cul3 Bub1 Stmn1 Klhl13 Sept1 Ncapd2 Ndc80 Incenp Kif23 Racgap1 Smc2 Cenpa Smc4 Sgol1 Psma3 Pebp1 Ncapg Ppp1cc Mylk Rasa1 Kif20a Des Vim Cbx5 Rhoa Aurkb Aurka Tacc1 Cdca8 Kif2c Npm1 Nsun2 N-CADHERIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%N-CADHERIN SIGNALING EVENTS N-cadherin signaling events Pip5k1c Ctnnd1 Plcg1 Ptpn1 Gsn Cdh2 Gja1 Rac1 Mapk8 Fgfr1 Kif5b Pik3r1 Gap43 Fer Rock1 Jup Mapre1 Dagla Rhoa Ptpn11 Cttn Cnr1 Dctn1 Lrp5 Camk2g Ctnna1 Daglb REGULATION OF TELOMERASE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF TELOMERASE Regulation of Telomerase Hdac2 Hdac1 Mre11a Nbn Mapk1 Fos Nfkb1 Jun Xrcc5 Ywhae Esr1 Xrcc6 Sp1 LOC100909750 E2f1 Hnrnpc Ccnd1 Tnks Akt1 Acd Ifng Parp2 Tinf2 LOC100911576 Blm Sin3a Max Hus1 Ube3a Atm Mxd1 Rad50 Znfx1 Rad1 Myc Egfr Abl1 Nr2f2 Pinx1 Tert Smg5 Smg6 Rps6kb1 Rbbp7 Tgfb1 RGD1561590 Wt1 Hdac1l Irf1 Sap18 Cdkn1b Pot1 Terf2ip Terf2 LOC103692716 Smad3 Terf1 Mtor Il2 TRK RECEPTOR SIGNALING MEDIATED BY PI3K AND PLC-GAMMA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TRK RECEPTOR SIGNALING MEDIATED BY PI3K AND PLC-GAMMA Trk receptor signaling mediated by PI3K and PLC-gamma Plcg1 Ywhae Ccnd1 Akt1 Camk4 Creb1 Src Kras Sfn Camk2a Gab1 Trpv1 Ntrk1 Egr1 Ywhaz Shc1 Ngf Bad Foxo3 Ywhab Pdpk1 Pik3r1 Trpc3 Stat5a Gsk3b Nras Hras Ywhag Ywhah Grb2 Prkcd Sos1 MTOR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%MTOR SIGNALING PATHWAY mTOR signaling pathway Btrc Fbxw11 Mapk1 Kras Sfn Prkca Raf1 Ywhaz Ywhab Nras Ywhag Ywhah Ikbkb Cdk2 Mapkap1 Sgk1 Ppargc1a Rb1cc1 Atg13 Rraga Eef2 Rragc Eif4b Rragd Ywhae Akt1 Ccne1 Eif4ebp1 Pml Srebf1 Rictor Bnip3 Ddit4 RragB Yy1 Pld2 Map2k2 Rptor Pld1 Rps6kb1 Rps6ka1 LOC100910121 Map2k1 Prr5 Pdpk1 Rrn3 Pdcd4 Tsc2 Hras Mlst8 Tsc1 Ulk2 Cycs Eif4a1 Akt1s1 Irs1 Poldip3 Mtor Eef2k Ulk1 ROLE OF CALCINEURIN-DEPENDENT NFAT SIGNALING IN LYMPHOCYTES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ROLE OF CALCINEURIN-DEPENDENT NFAT SIGNALING IN LYMPHOCYTES Role of Calcineurin-dependent NFAT signaling in lymphocytes Prkch Nr4a1 Prkcb Ywhae Prkcz Camk4 Crebbp Mapk8 Kpna2 Csnk2a1 Casp3 Sfn Prkca Akap5 Xpo1 Mef2d Ywhaz Bad Ran Kpnb1 Ywhab Rcan2 Map3k8 Gsk3b Prkcq Csnk1a1 Ywhag Mapk9 Chp1 Ywhah Prkaca LOC100912399 Mapk14 Bcl2l1 Nfatc3 Map3k1 Fkbp1a Cabin1 Prkcd Nfatc2 Fkbp8 Pim1 Bcl2 IL6-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL6-MEDIATED SIGNALING EVENTS IL6-mediated signaling events Akt1 A2m Crp Rac1 Map2k6 Jak1 Hsp90b1 Fos Mitf Gab2 Map2k4 Myc Jun Il6 Pias3 Gab1 Lbp Timp1 Junb Mapk11 Pias1 Hck Pik3r1 Stat3 Irf1 Il6st Grb2 Lmo4 Bcl2l1 Mapk14 Ptpn11 Fgg Vav1 Stat1 Prkcd Foxo1 Sos1 Ptpre Socs3 SIGNALING EVENTS MEDIATED BY THE HEDGEHOG FAMILY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY THE HEDGEHOG FAMILY Signaling events mediated by the Hedgehog family Arrb2 Dhh Shh Lrpap1 Ptch1 Cdon Gli2 Pik3r1 Boc Adrbk1 Ihh Smo Lrp2 Akt1 Tgfb2 Hhip SYNDECAN-3-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-3-MEDIATED SIGNALING EVENTS Syndecan-3-mediated signaling events LOC102550316 Aph1b Src Mc4r Egfr Ncan Fgfr4 Fgf19 Psenen Fgfr3 Pomc Fyn Ncstn Ptn Psen1 Agrp LOC100911293 Fgf23 Sdc3 Cttn ATYPICAL NF-KAPPAB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATYPICAL NF-KAPPAB PATHWAY Atypical NF-kappaB pathway Arrb2 Src Pik3r1 Rela Lck Nfkb1 Ikbkb Mapk14 Btrc Syk Nfkbia ARF1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF1 PATHWAY Arf1 pathway Rac1 Cyth2 Ap2a1 Gosr2 Ap2m1 Gga3 Clta Pld2 Gbf1 Kdelr1 Asap1 Cd4 Uso1 Cltb Arfip2 Arfgap1 EGFR-DEPENDENT ENDOTHELIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EGFR-DEPENDENT ENDOTHELIN SIGNALING EVENTS EGFR-dependent Endothelin signaling events Ednra Hras Egfr Grb2 Edn1 Sos1 Shc1 Mtor ATR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATR SIGNALING PATHWAY ATR signaling pathway Cdk2 Rad17 Cdc6 Smarcal1 Mcm2 Fancd2 Mdm2 Mcm7 Stt3a Ccna2 Cep164 LOC100911267 Cdc25a Topbp1 Plk1 Timeless Btrc Rad51 Atrip Cdc25c Rfc5 Rfc2 Rfc4 Rfc3 Nbn Fbxw11 Atr Brca2 Hus1 Rad1 Rpa1 Rpa2 Ywhaz Ywhab Ppp2ca Clspn Ppp2r1a FOXA TRANSCRIPTION FACTOR NETWORKS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXA TRANSCRIPTION FACTOR NETWORKS FOXA transcription factor networks Foxa1 Foxa2 Foxa3 S1P3 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P3 PATHWAY S1P3 pathway Gnao1 Mapk1 Gnai3 Rac1 Src Gna15 Gna14 Gna13 Gna12 Gna11 Gnaq LOC100911280 Vegfa Flt1 S1pr3 Gnai2 Pdgfb Gnai1 Pdgfrb Gnaz Akt3 Rhoa Cxcr4 Akt1 SHP2 SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SHP2 SIGNALING SHP2 signaling Gnai3 Kras Raf1 Gab1 Vegfa Ntrk1 Ngf Shc1 Nras Prkaca Rhoa Lck Tek Ntf4 Ntf3 Sdc2 Il2rg Pdgfb Gnai1 Pdgfrb Ifng Jak1 Gab2 Egfr Il6 Map2k2 Arhgap35 Nos3 Map2k1 Ifngr1 Pik3r1 Bdnf Jak3 Angpt1 Hras Il2ra Igf1r Frs2 Il6st Lmo4 Frs3 Grb2 Ntrk3 Ptpn11 Ntrk2 Stat1 Irs1 Sos1 Il2 IL2 SIGNALING EVENTS MEDIATED BY PI3K%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL2 SIGNALING EVENTS MEDIATED BY PI3K IL2 signaling events mediated by PI3K Lck Sgms1 Eif3a Smpd1 Il2rg E2f1 Akt1 Prkcz Rac1 Jak1 Gab2 Nfkb1 Myc Tert Shc1 Rps6kb1 Foxo3 Pik3r1 Jak3 Rela Ugcg Il2ra Rps6 LOC100911372 Grb2 Bcl2l1 Ptpn11 LOC103692716 Sos1 Mtor Bcl2 Il2 EPHA FORWARD SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHA FORWARD SIGNALING EPHA forward signaling Efna1 Pik3cg Efna2 Fgr Crkl Cdk5 Lck Cbl Arhgef15 Plcg1 Fyn Epha8 Epha7 Blk LOC100912512 Ngef Epha4 Pik3r6 Vav3 Crk Yes1 Epha1 LOC100911248 Epha3 Epha2 Src Hck Vav2 Rock1 Lyn Rhoa P38 MAPK SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P38 MAPK SIGNALING PATHWAY p38 MAPK signaling pathway Map3k3 Rac1 Txn1 Map2k6 Map3k6 Traf2 Atm Map3k4 Gadd45g Taok3 Tab2 Gadd45a Taok1 Gadd45b Mapk11 Map3k10 Map3k7 Mapk14 LOC100912399 Traf6 Map3k1 REELIN SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REELIN SIGNALING PATHWAY Reelin signaling pathway Lrpap1 Crkl Cdk5 Cbl Fyn Map3k11 Pafah1b1 Arhgef2 Vldlr Grin2b Reln Rap1a Dab1 Itga3 Cdk5r1 Map1b Akt1 Nck2 LOC100911248 Map2k7 Lrp8 Mapk8 Pik3r1 Gsk3b Itgb1 IL3-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL3-MEDIATED SIGNALING EVENTS IL3-mediated signaling events Id1 Prkacb Hdac1 Gab2 Il3ra Cnksr1 Ywhaz Shc1 Osm Srp9 Cish Pik3r1 Stat5a Hdac1l Ywhag Prkaca Bcl2l1 Grb2 Ptpn11 Csf2rb Stat5b Pim1 VEGFR1 SPECIFIC SIGNALS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VEGFR1 SPECIFIC SIGNALS VEGFR1 specific signals Mapk1 Prkca Cbl LOC100911280 Vegfa Flt1 Plcg1 Prkcb Shc2 Nos3 Pdpk1 Pik3r1 Rasa1 Prkaca Ptpn11 Nrp1 LOC103692716 Nrp2 Akt1 Nck1 Cd2ap Pgf Hif1a ARF6 TRAFFICKING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF6 TRAFFICKING EVENTS Arf6 trafficking events Pip5k1c Ctnnd1 Itga7 Exoc5 Itga6 Exoc3 Rala Itga5 Scamp2 Acap1 Itga3 Tshr Nme1 Cltc LOC100360745 Exoc7 Klc1 Agtr1a Ins2 Itga4 Exoc6 Itga11 Exoc2 Spag9 Itga10 Pld2 Cdh1 Arf6 Itga8 Pld1 Bin1 Itgb1 Adrb2 Vamp3 Dnm2 Slc2a4 Ctnna1 Mapk8ip3 CALCIUM SIGNALING IN THE CD4+ TCR PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CALCIUM SIGNALING IN THE CD4+ TCR PATHWAY Calcium signaling in the CD4+ TCR pathway Pou2f1 Ptgs2 Batf3 Cd40lg Akap5 Fos Faslg Jun Junb Fosl1 Rcan2 Il4 Csf2 Il2ra Chp1 Prkaca Nfatc3 Fkbp1a Cabin1 Nfatc2 Ifng Il2 INTEGRIN FAMILY CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTEGRIN FAMILY CELL SURFACE INTERACTIONS Integrin family cell surface interactions Itga4 Itga11 Itga10 Itga8 Itgax Itga7 Itgb7 Itga6 Itgb8 Itga2b Itgb4 Itga5 Itgb6 Itgal Itgb2 Itga3 Itgb1 Itgam RAPID GLUCOCORTICOID SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RAPID GLUCOCORTICOID SIGNALING Rapid glucocorticoid signaling Mapk8 Mapk9 Mapk14 Gnal Gnb1 Mapk11 Crh VEGFR3 SIGNALING IN LYMPHATIC ENDOTHELIUM%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VEGFR3 SIGNALING IN LYMPHATIC ENDOTHELIUM VEGFR3 signaling in lymphatic endothelium Mapk1 Creb1 Vegfc Figf Itga4 Fn1 Map2k4 Flt4 Col1a2 Col1a1 Shc1 Mapk11 Rps6ka1 Pik3r1 Itga5 Grb2 Mapk14 Crk Itgb1 Akt1 Sos1 GLYPICAN 3 NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN 3 NETWORK Glypican 3 network Furin Mapk8 Shh Ptch1 Mapk9 Fgf7 Bmp4 GMCSF-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GMCSF-MEDIATED SIGNALING EVENTS GMCSF-mediated signaling events Mapk1 Prkacb Kras Raf1 Fos Gab2 Ywhaz Map2k2 Shc1 Osm Cish Map2k1 Pik3r1 Stat3 Ccl12 Csf2 Stat5a Irf8 Nras Hras Prkaca Ikbkb Lyn Grb2 Ptpn11 Syk Stat1 Csf2rb Sos1 Stat5b Pim1 PROTEOGLYCAN SYNDECAN-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PROTEOGLYCAN SYNDECAN-MEDIATED SIGNALING EVENTS Proteoglycan syndecan-mediated signaling events Sdc4 Sdc3 Sdc2 RAC1 SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RAC1 SIGNALING PATHWAY RAC1 signaling pathway Iqgap1 Plcb2 Brk1 Crk Abi1 Cybb Abi2 Cyba Baiap2 Noxa1 Limk1 Rac1 Mapk8 Cfl1 Bcar1 Atf2 Iqgap3 Actr3 Actr2 Arhgdia Jun Nckap1 Arpc3 Noxo1 Pip5k1b Cdh1 Pak2 Arhgap5 Pak1 Arpc4 Arpc5 Wasf1 Arpc2 Arpc1b Mapk9 Ncf2 Ncf1 Mapk14 Ctnna1 Pip5k1c Map3k11 Map2k7 Map2k6 Map2k4 Racgap1 Stat5a Stat3 LOC100912399 Map3k1 EPHA2 FORWARD SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHA2 FORWARD SIGNALING EPHA2 forward signaling Efna1 Rac1 Src Bcar1 Cbl Ptk2 Shc1 Pak1 Arhgap35 Pik3r1 Vav2 Grb2 Rhoa Vav3 Tiam1 Epha2 Acp1 NETRIN-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NETRIN-MEDIATED SIGNALING EVENTS Netrin-mediated signaling events Plcg1 Fyn Yes1 Map1b Mapk1 Src Rac1 Bcar1 Camk2a Ptk2 Unc5c Map2k2 Unc5b Pak1 Dcc Map2k1 Pitpna LOC100909609 Pik3r1 Ntn1 Dock1 Dapk1 Myo10 Trio Rhoa Nck1 ALPHA9 BETA1 INTEGRIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA9 BETA1 INTEGRIN SIGNALING EVENTS Alpha9 beta1 integrin signaling events Rac1 Src Bcar1 Vegfc Figf Fn1 Vegfa Adam12 Csf2 Adam15 Spp1 Paox Pxn F13a1 Tgm2 Vcam1 Itgb1 Adam8 Kcnj15 Adam2 LOC497963 Sat1 CANONICAL NF-KAPPAB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CANONICAL NF-KAPPAB PATHWAY Canonical NF-kappaB pathway Erc1 Prkca Ripk2 Xpo1 Atm Cyld Birc2 Nfkb1 Ube2d3 Bcl10 Tnfrsf1a Nod2 Btrc Chuk Ran Rela Ikbkb Traf6 Nfkbia VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL REPRESSION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL REPRESSION Validated targets of C-MYC transcriptional repression Tjp2 Hdac1 Nfyc Nfyb Brca1 Nfya Ndrg1 Ndrg2 Tbp Ppp2r4 Cdkn1a Zbtb17 Tmeff2 Lgals1 Cflar Dkk1 Slc11a1 Aldh9a1 Dnmt3a Smad2 Itga6 Wnt5a Fth1 Id2 Clu Ddit3 Gfi1 Hdac3 Gadd45a Ccl5 Foxo3 Itgb1 Bcl2 Cebpa Pdgfrb Sp1 Itgb4 Ccnd1 Creb1 Max Myc Col1a2 Rbl1 Dntt Spi1 Tmem126a Hdac1l Irf8 Cdkn2b Tsc2 Erbb2 Sfrp1 Cdkn1b Mxd4 Hmgcs2 Smad3 Sfxn3 Gtf2h2 NONGENOTROPIC ANDROGEN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NONGENOTROPIC ANDROGEN SIGNALING Nongenotropic Androgen signaling Plcg1 Gnai2 Gnai1 Gnaz Plcb2 Akt1 Gnb1 Pelp1 Mapk1 Gnao1 Creb1 Gnai3 Src Rac1 Plcb3 Shbg Plcb1 Raf1 Fos Ar Gnrh1 Ptk2 Map2k2 Map2k1 Pik3r1 Hras FAS (CD95) SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FAS (CD95) SIGNALING PATHWAY FAS (CD95) signaling pathway Birc2 Faslg Smpd1 Cflar Mapk10 Bid Casp8 Pik3cb Rfc1 Ezr Akt1 Ripk1 Fas Birc3 Map2k7 Fadd Src Mapk8 Map2k6 Cltc Casp3 Chuk Mapk11 Pdpk1 Pik3r1 Mapk9 Ikbkb Mapk14 LOC100912399 Map3k1 Syk ALPHA-SYNUCLEIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA-SYNUCLEIN SIGNALING Alpha-synuclein signaling Fgr Lck Ptk2b Uchl1 Grk5 Snca Fyn Blk Plcb2 Yes1 Src Csnk2a1 Pld2 Pld1 Bad Klk6 Tor1a Slc6a3 Hck Th Park7 Ube2l3 Maob Lyn Fkbp1a Syk Prkcd P63 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P63 TRANSCRIPTION FACTOR NETWORK p63 transcription factor network Tp63 DNA-PK PATHWAY IN NONHOMOLOGOUS END JOINING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DNA-PK PATHWAY IN NONHOMOLOGOUS END JOINING DNA-PK pathway in nonhomologous end joining Dclre1c Polm Prokr1 Nhej1 Aptx Pnkp Poll Aplf Prkdc Lig4 Xrcc4 Xrcc5 Dntt Xrcc6 SIGNALING EVENTS MEDIATED BY VEGFR1 AND VEGFR2%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY VEGFR1 AND VEGFR2 Signaling events mediated by VEGFR1 and VEGFR2 Myof Sh2d2a Cdh5 Ptpn2 Camkk2 Hsp90ab1 Cbl Akap1 Vcl Vtn Fes Grb10 Mapkapk2 Ptprj Prkcb Iqgap1 Fbxw11 Mapk1 Src Prkca Raf1 LOC100911280 Gab1 Vegfa Flt1 Ptk2 Pak2 Rock1 Prkaca Rhoa Mapk14 Prkcd Dnm2 Ctnna1 Ptk2b Plcg1 Fyn Pxn Akt1 Nck2 Map2k6 Map2k2 Mapk11 Map2k1 Nos3 Pik3r1 Pdpk1 Ptpn6 Grb2 Ptpn11 LOC103692716 Nck1 SIGNALING EVENTS MEDIATED BY HDAC CLASS III%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HDAC CLASS III Signaling events mediated by HDAC Class III Hdac4 Fhl2 Crebbp Sirt2 Sirt3 Ppargc1a Mef2d Cdkn1a Foxo3 Xrcc6 Tubb2a Foxo4 Myod1 Acss2 LOC100909443 Tp53 Foxo1 Bax Hoxa11 Acss1 ALPHA4 BETA1 INTEGRIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA4 BETA1 INTEGRIN SIGNALING EVENTS Alpha4 beta1 integrin signaling events Thbs2 Amica1 Prkar1b Adam28 Ptk2b Igsf8 Cd81 Git1 Ptpra Tln1 Cd14 Mdk Spp1 Pxn Vcam1 Crk Abi1 Src Prkacb Rac1 Bcar1 Itga4 Fn1 Ptk2 Ywhaz Arf6 LOC100909609 Dock1 Prkaca Itgb1 P75(NTR)-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P75(NTR)-MEDIATED SIGNALING p75(NTR)-mediated signaling Rtn4r Apaf1 Zfp110 Xiap Diablo Rhoc Rhob Prkcz Sort1 Rac1 Mapk8 Casp3 Adam17 Smpd2 Plg LOC100912195 Ngfrap1 Arhgdia Ntrk1 Chuk Shc1 Ngf Bad Casp6 Casp9 Rtn4 Ndn Mmp7 Ngfr Mapk9 Myd88 Prdm4 App Ikbkb Rhoa Sqstm1 Mag Bcl2l11 Prkci Maged1 Omg Mageh1 Aph1b Ripk2 Birc2 Ntf4 Psenen Ntf3 Mapk10 Ywhae Ncstn Psen1 LOC100911293 E2f1 Akt1 Birc3 Prkacb Furin Pik3r1 Bdnf Cycs Traf6 Tp53 WNT SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%WNT SIGNALING NETWORK Wnt signaling network Igfbp4 Rspo1 Ror2 Wnt7b Fzd1 Wnt7a Atp6ap2 Kremen2 Wnt3 Wnt1 Fzd6 Fzd4 Wnt3a Dkk1 Fzd5 Fzd2 Wif1 Wnt5a Ryk Cthrc1 Lrp6 Fzd9 Lrp5 TRK RECEPTOR SIGNALING MEDIATED BY THE MAPK PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TRK RECEPTOR SIGNALING MEDIATED BY THE MAPK PATHWAY Trk receptor signaling mediated by the MAPK pathway Rit1 Rit2 Rap1b Map3k2 Cdk5 Srf Mapkapk2 Ehd4 Map2k5 Ntf3 Mef2c Rps6ka5 Rap1a Cdk5r1 Mapk1 Creb1 Kras Map2k6 Raf1 Fos Trpv1 Egr1 Rps6ka1 Map2k1 Nras Hras Elk1 Mapk14 Prkcd ARF6 DOWNSTREAM PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF6 DOWNSTREAM PATHWAY Arf6 downstream pathway Mapk1 Rab11a Kalrn Nme1 Rac1 Rhoa Pld2 Arf6 Tiam1 Pld1 SIGNALING EVENTS REGULATED BY RET TYROSINE KINASE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS REGULATED BY RET TYROSINE KINASE Signaling events regulated by Ret tyrosine kinase Grb10 Pxn Rap1a Crk Mapk1 Creb1 Rac1 Src Mapk8 Bcar1 Prkca Grb7 Dok1 Jun Dok6 Gab1 Dok4 Irs2 Ret Ptk2 Gdnf Shc1 Pdlim7 Shank3 Pik3r1 Rasa1 Hras Prkaca Frs2 Rhoa Grb2 Ptpn11 Irs1 Nck1 Sos1 EFFECTS OF BOTULINUM TOXIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EFFECTS OF BOTULINUM TOXIN Effects of Botulinum toxin Rab3gap2 Unc13b Vamp2 Syt1 Chrna1 Stx1a Stxbp1 NECTIN ADHESION PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NECTIN ADHESION PATHWAY Nectin adhesion pathway Ptprm Cldn1 Rac1 Src Rap1b Pip5k1c Ptk2 Cdh1 Tln1 Pdgfb Pik3r1 Pdgfrb Vav2 Rap1a Iqgap1 Pvrl1 Crk F11r Pvrl3 Ctnna1 Farp2 Pvrl2 STABILIZATION AND EXPANSION OF THE E-CADHERIN ADHERENS JUNCTION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%STABILIZATION AND EXPANSION OF THE E-CADHERIN ADHERENS JUNCTION Stabilization and expansion of the E-cadherin adherens junction Efna1 Vcl Pip5k1c Ctnnd1 Git1 Diaph1 Mgat3 Vasp Lima1 Exoc3 Stx4 Aqp3 Zyx Enah Myo6 Hgf Lpp Kifc3 Abi1 Epha2 Egfr Nckap1 Cdh1 Arf6 Rock1 Igf1r Rhoa Actn1 Nck1 Ctnna1 Pvrl2 IGF1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IGF1 PATHWAY IGF1 pathway Crkl Grb10 Ptpn1 Ywhae Pxn Crk Akt1 LOC100911248 Nck2 Prkd1 Prkcz Bcar1 Raf1 Irs2 Ptk2 Ywhaz Shc1 Bad Rps6kb1 Pdpk1 Pik3r1 Hras Igf1r Grb2 Ptpn11 Irs1 Prkcd Sos1 SIGNALING EVENTS MEDIATED BY HEPATOCYTE GROWTH FACTOR RECEPTOR (C-MET)%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HEPATOCYTE GROWTH FACTOR RECEPTOR (C-MET) Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) Ptpn2 Crkl Cbl Ptprj Hgf Crk LOC100911248 Mapk1 Prkcz Mapk8 Rac1 Src Bcar1 Raf1 Jun Gab1 Ptk2 Rin2 Egr1 Cdh1 Pak2 Shc1 Arf6 Sh3kbp1 Pard6a Pak1 Bad F2rl2 Kpnb1 Pak4 Sh3gl2 Snai1 Ranbp10 Muc20 Arhgef4 Apc Akt2 Rhoa Ets1 Prkci Ctnna1 Rap1b Plcg1 Ptpn1 Pxn Rap1a Akt1 Nck2 Eif4ebp1 Gab2 Map2k4 Map2k2 Rptor Map2k1 Pik3r1 Pdpk1 Hras Mlst8 Grb2 LOC100912399 Ptpn11 Map3k1 Akt1s1 Nck1 Sos1 Mtor ATM PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATM PATHWAY ATM pathway Rad17 Fancd2 Brca1 Mdm2 Trim28 Fam175a Rbbp8 Cdc25a Chek2 Kat5 Ube2n Uimc1 Smc3 Smc1a Cdc25c Ctbp1 Tp53bp1 Bid LOC100909750 Mre11a Nbn Blm H2afx Dclre1c Atm Rad50 Abl1 Xrcc4 Ywhab Terf2 TCR SIGNALING IN NAIVE CD8+ T CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TCR SIGNALING IN NAIVE CD8+ T CELLS TCR signaling in naive CD8+ T cells Trpv6 Cd86 Orai1 Lck Cbl Stim1 B2m Plcg1 Lat Cd28 Rassf5 Cd8b Cd8a Fyn Prkcb Cd80 Rasgrp2 Rasgrp1 Cd3e Lcp2 Cd247 Cd3d Map3k14 Zap70 Rap1a Akt1 Cd3g Kras Prkca Bcl10 Chuk Shc1 Ptprc Pdpk1 Map3k8 Prkcq Ptpn6 Nras Hras Ikbkb Grb2 Traf6 Vav1 Csk Sos1 LPA RECEPTOR MEDIATED EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LPA RECEPTOR MEDIATED EVENTS LPA receptor mediated events Crk Prkd1 Gnao1 Src Gnai3 Rac1 Gna15 Gna14 Bcar1 Casp3 Gna13 Gna12 Fos Gna11 Nfkb1 Gnaq Jun Gab1 Ptk2 Mmp9 Gsk3b Rela Rhoa Prkcd Tiam1 Ptk2b Plcg1 Gnai2 Gnai1 Gnaz Pxn Pik3cb Akt1 Gnb1 Lpar3 Plcb3 Slc9a3r2 Adcy3 Lpar4 Lpar2 Lpar1 Egfr Adcy8 Adcy7 Hbegf Pld2 Adcy5 Adcy4 Adcy6 Mmp2 Pik3r1 Hras Lyn Nfkbia RXR AND RAR HETERODIMERIZATION WITH OTHER NUCLEAR RECEPTOR%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RXR AND RAR HETERODIMERIZATION WITH OTHER NUCLEAR RECEPTOR RXR and RAR heterodimerization with other nuclear receptor Srebf1 Thrb Nr1h2 Med1 Nr4a1 Rps6kb1 Ppara Tgfb1 Rxrg Rara Ppard Rxrb Fam120b Rxra Vdr Ncoa1 Rarg Ncor2 Thra Nr1h3 Abca1 Nr1h4 Bcl2 Pparg NOTCH SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NOTCH SIGNALING PATHWAY Notch signaling pathway Aph1b Hdac1 Cbl Rbbp8 Cdkn1a Btrc Psenen Ctbp1 Dlk1 Ncstn Neurl1 LOC100911293 Ccnd1 Notch2 Notch1 Dll3 Lnx1 Mib1 Gata3 Notch4 Notch3 Myc Eno1 Cul1 Maml1 Yy1 Cntn6 Kdm1a Mark2 Cntn1 Ptcra Adam12 Furin Rab11a Il4 Hdac1l Skp2 Dll4 Dnm1 Ncor2 Skp1 Mfap5 Jag1 Dner Mfap2 DIRECT P53 EFFECTORS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DIRECT P53 EFFECTORS Direct p53 effectors Dusp1 Hdac2 Irf5 Dusp5 Htt LOC502894 Carm1 Tp53inp1 Pcna Cx3cl1 Pou4f2 Tp73 Cse1l Bak1 Tgfa Prdm1 Edn2 Prmt1 Plk3 Hgf Cd82 Tada2b Serpine1 Smarca4 Col18a1 Epha2 LOC100911519 Crebbp Gadd45a Apc Tp63 Bcl2l1 Bcl2 Btg2 Rnf144b Pms2 Gpx1 Bid LOC100910137 Msh2 Perp Bnip3l Tp53bp2 Pycard Mlh1 Hspa1a E2f1 E2f3 Hspa1b Rchy1 Ppp1r13b Fas Sh2d1a Kat2a Ccng1 Atf3 Tap1 Tyrp1 Steap3 Igfbp3 Taf9 Ctsd Lif Egfr Serpinb5 Cebpz Triap1 Rrm2b Bcl2l2 Bcl2l14 Bcl6 Mmp2 Drosha Gdf15 Ddx5 Sesn1 Ccnk Prkab1 Casp1 Ppm1j Vcan Nlrc4 Pidd1 Rb1 Dgcr8 Pcbp4 Fdxr Bdkrb2 Zfp385a Nfyc Nfyb Mdm2 Nfya Ndrg1 Cdkn1a Apaf1 Dkk1 Pten Sfn Jun Casp6 Bcl2a1 Vdr Foxa1 Sp1 Spp1 Afp Pml Ddit4 Tsc2 Tp53 Bax BETA5 BETA6 BETA7 AND BETA8 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA5 BETA6 BETA7 AND BETA8 INTEGRIN CELL SURFACE INTERACTIONS Beta5 beta6 beta7 and beta8 integrin cell surface interactions Itgb7 Itgb8 Itgb6 Itga4 Fn1 Tgfbr1 Vtn Vcam1 Cyr61 Fbn1 Plau Madcam1 POSTTRANSLATIONAL REGULATION OF ADHERENS JUNCTION STABILITY AND DISSASSEMBLY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%POSTTRANSLATIONAL REGULATION OF ADHERENS JUNCTION STABILITY AND DISSASSEMBLY Posttranslational regulation of adherens junction stability and dissassembly Ctnnd1 Ptpn1 Cdh2 Fyn LOC100909750 Iqgap1 Crebbp Src Rac1 Nme1 Casp3 Gna13 Gna12 Egfr Abl1 Slit1 Ret Rin2 Gdnf Cdh1 Arf6 Rab7a Cables1 Robo1 Bdnf LOC100910807 Zbtb33 Mmp7 Dsp Ptpn6 Hras Cbll1 Jup Igf1r Igf2 Ntrk2 Snx1 Dnm2 Tiam1 Ctnna1 VALIDATED NUCLEAR ESTROGEN RECEPTOR ALPHA NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED NUCLEAR ESTROGEN RECEPTOR ALPHA NETWORK Validated nuclear estrogen receptor alpha network Hdac1 Tff1 Brca1 Calcoco1 Mta1 Set Apbb1 Pcna Safb Pou4f2 Med1 Cd82 Col18a1 Jun Chuk Ncoa1 Ncor2 Esr1 Ccnd1 Hdac4 Esr2 Hsf2 Ctsd Dscam Myc Ebag9 Ube2m Ndufv3 Xbp1 Prdm15 Atp5j Nr0b2 Ncoa7 Nedd8 Anp32a Nr0b1 Pgr Stat5a Nrip1 Hdac1l Prl C3 Uba3 Ncoa2 Sra1 Lmo4 Mpg Axin2 Phb2 Ddx54 Ap1b1 Sod1 Abca3 ERBB1 DOWNSTREAM SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB1 DOWNSTREAM SIGNALING ErbB1 downstream signaling Dusp1 Sh2d2a Rala Iqgap1 Brk1 Abi1 Baiap2 Mapk1 Prkcz Mapk8 Rac1 Src Kras Sfn Raf1 Atf2 Prkca Fos Actr3 Actr2 Jun Nckap1 Gab1 Arpc3 Egr1 Ywhaz Bad Arpc4 F2rl2 Arpc5 Ywhab Arpc2 Arpc1b Nras Vav2 Ywhag Mapk9 Rps6 LOC100911372 Ywhah Bcl2l1 Ppp2ca Prkcd Ppp2r1a Mapkap1 Map3k2 Ppp5c Ksr1 Ralgds Srf Mylpf Arf4 Rps6ka3 Ppp2r2a Usp6nl Eps8 Slc9a1 Map2k5 Mef2c Atf1 Dusp6 Rps6ka5 Rin1 Ywhae Smad1 Capn2 LOC100911794 Pik3cb Akt1 Creb1 Rictor Map2k4 Egfr Pld2 Map2k2 Pld1 Pebp1 Map2k1 Pdpk1 Pik3r1 Stat3 Hras Mlst8 Elk1 Grb2 LOC100912399 Map3k1 Stat1 Sos1 Mtor INTERNALIZATION OF ERBB1%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTERNALIZATION OF ERBB1 Internalization of ErbB1 Usp8 Amph Cbl Ube2d3 Pik3cb Src Kras Raf1 Egfr Ptk2 Sh3kbp1 Shc1 LOC100909679 Synj1 Tsg101 Sh3gl2 Pik3r1 Chmp3 LOC100910792 Cblb Nras Hras Lrig1 Grb2 Zfyve28 Dnm1 Stambp Arhgef7 Ube2d1 Sos1 Spry2 Itsn1 Epn1 VISUAL SIGNAL TRANSDUCTION: RODS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VISUAL SIGNAL TRANSDUCTION: RODS Visual signal transduction: Rods Rpe65 Gucy2f Guca1b Gnb5 Rgs9 Rgs9bp Rho Grk1 Guca1a Gnat1 Pde6a Pde6b Cnga1 Gngt1 Gnb1 Sag Lrat Gucy2d CDC42 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CDC42 SIGNALING EVENTS CDC42 signaling events Cbl Enah Iqgap1 Yes1 Baiap2 Mapk1 Prkcz Src Limk1 Rac1 Mapk8 Cfl1 Bcar1 Atf2 Exoc7 Raf1 Iqgap3 Actr3 Actr2 Jun Arhgdia Arpc3 Cdh1 Pak2 Pard6a Pak1 Arpc4 F2rl2 Arpc5 Pak4 Gsk3b Arpc2 Arpc1b Vav2 Mapk9 Apc Mapk14 Arhgef7 Tiam1 Ctnna1 Limk2 Sept2 Eps8 Hes5 Tnk2 Dlg1 Pax6 Arhgef6 Map3k11 Cdc42bpa Map2k7 Map2k6 Map2k4 Pld1 Rps6kb1 Pik3r1 Hras LOC100912399 Map3k1 Mtor REGULATION OF CYTOPLASMIC AND NUCLEAR SMAD2 3 SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF CYTOPLASMIC AND NUCLEAR SMAD2 3 SIGNALING Regulation of cytoplasmic and nuclear SMAD2 3 signaling Mapk1 Kpnb1 Smad2 Kpna2 Ube2i Pias4 LOC100912399 Ctdsp1 Nup153 Map3k1 Ctdspl Smad3 OSTEOPONTIN-MEDIATED EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%OSTEOPONTIN-MEDIATED EVENTS Osteopontin-mediated events Ptk2b Gsn Plau Spp1 Map3k14 Vav3 Mapk1 Cd44 Mapk8 Rac1 Ilk Bcar1 Fos Nfkb1 Rock2 Jun Chuk Mmp9 Mmp2 Pik3r1 Rela LOC100912399 Rhoa Syk Map3k1 Nfkbia INTEGRINS IN ANGIOGENESIS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTEGRINS IN ANGIOGENESIS Integrins in angiogenesis Cbl Vcl Vtn Csf1r Vav3 Mfge8 Mapk1 Src Csf1 Rac1 Col11a1 Col11a2 Bcar1 Col4a1 Col4a3 Col5a2 Fn1 Tgfbr2 Col4a5 Col5a1 Fgf2 Vegfa Col6a2 Pi4kb Ptk2 Angptl3 Col6a1 Col3a1 Pik3c2a Rock1 Rhoa F11r LOC100911572 Ptk2b Tln1 Casp8 Spp1 Pxn Akt1 Ilk Col1a2 Col1a1 Rps6kb1 Pik3r1 Cdkn1b Igf1r Ptpn11 LOC103692716 Irs1 NOTCH-MEDIATED HES HEY NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NOTCH-MEDIATED HES HEY NETWORK Notch-mediated HES HEY network Hdac1 Hey2 Hey1 Twist1 Rbbp8 Tle1 Parp1 Ptf1a Gaa Gata4 Gata1 Ctbp1 LOC100911167 Arnt E2f1 Crebbp Notch1 Ar Hes1 Maml1 Yy1 Kdm1a Cd4 Stat3 Hdac1l Cdkn1b Ncoa1 Neurog3 Hes6 Myod1 Rb1 Ncor2 Runx2 Camk2d Bglap Ascl1 Hif1a Ghr ENDOTHELINS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ENDOTHELINS Endothelins Prkch Prkcb Edn2 Plcb2 Crk Edn1 Gnao1 Mapk1 Src Gnai3 Rac1 Mapk8 Gna15 Bcar1 Gna14 Prkca Raf1 Gna12 Fos Gna11 Gnaq Jun Col3a1 Mmp1 Cysltr2 Cysltr1 Ednrb Edn3 Prkcq Slc9a3 Rhoa Mapk14 Prkcd Pla2g4a Ptk2b Trpc6 Slc9a1 Gnai2 Gnai1 Gnaz Akt1 Gnal Plcb3 Adcy3 Plcb1 Ednra Col1a2 Adcy8 Adcy7 Adcy5 Map2k2 Adcy4 Adcy6 Map2k1 Hras CXCR4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CXCR4-MEDIATED SIGNALING EVENTS CXCR4-mediated signaling events Pik3cg Fgr Rhoc Rhob Blk Pik3r6 Plcb2 Crk Yes1 Cxcl12 Prkcz Gnao1 Rac1 Gnai3 Src Limk1 Cfl1 Bcar1 Gna13 Ptk2 Mmp9 Bad Pak1 Ptprc Rhoa Cxcr4 Csk Arrb2 Mapkap1 Rap1b Lck Ssh1 Ptk2b Fyn Gnai2 Ralb Grk6 Cd3e Gnai1 Gnaz Cd247 Cd3d Pxn Rgs1 Pik3cb Arr3 Adrbk1 RT1-Da RT1-Db1 Akt1 Vps4a Vps4b Gnb1 Cd3g Ubqln1 Stat2 Plcb3 Plcb1 Rictor Cd4 Pik3r1 Pdpk1 Hck Stat5a Stat3 Ptpn6 Mlst8 Lyn Ptpn11 Dnm1 Vav1 Stat1 Foxo1 Stat5b Mtor PDGFR-ALPHA SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PDGFR-ALPHA SIGNALING PATHWAY PDGFR-alpha signaling pathway Jak1 Csnk2a1 Crkl Fos Srf Jun Plcg1 Shc1 Pik3r1 Shf Pdgfra Cav3 Elk1 Grb2 Crk Sos1 LOC100911248 SIGNALING BY AURORA KINASES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING BY AURORA KINASES Signaling by Aurora kinases Aurkb Aurka REGULATION OF P38-ALPHA AND P38-BETA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF P38-ALPHA AND P38-BETA Regulation of p38-alpha and p38-beta Dusp1 Fgr Lck Fyn Ralb Blk Rala Yes1 Ripk1 Map3k3 Rac1 Src Map2k6 Map2k4 Map3k12 Pak2 Dusp10 Mapk11 Pak3 Pak1 Dusp16 Hck Lyn Mapk14 Traf6 PAR4-MEDIATED THROMBIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PAR4-MEDIATED THROMBIN SIGNALING EVENTS PAR4-mediated thrombin signaling events F2rl2 Gna15 Gna14 Gna13 Rock1 Gna11 Rock2 Gnaq Plcb2 Rhoa F2 Gnb1 BETA2 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA2 INTEGRIN CELL SURFACE INTERACTIONS Beta2 integrin cell surface interactions Cd40lg Cyr61 Plau Itgax Fga Fgb Spon2 F10 Icam1 Thy1 Gp1ba C3 Jam3 Icam2 Plat Itgal Proc Itgb2 Vcam1 Fgg Itgam LOC103693683 F11r REGULATION OF NUCLEAR BETA CATENIN SIGNALING AND TARGET GENE TRANSCRIPTION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF NUCLEAR BETA CATENIN SIGNALING AND TARGET GENE TRANSCRIPTION Regulation of nuclear beta catenin signaling and target gene transcription Hdac2 Hdac1 Tle1 Btrc Dkk1 Ctbp1 Id2 Smarca4 Myf5 Camk4 Myog Hbp1 Cby1 Sfn Ctnnbip1 Lef1 Xpo1 Tcf7l1 Dvl3 Jun Klf4 Tnik Pitx2 Tbl1xr1 Tcf4 Dkk4 Cdh1 Ywhaz Mmp9 Mt-co2 Aes Ywhab Ywhag Apc Ywhah Sp5 Tbl1x Krt1 Tcf7 Igf2bp1 Neurog1 Cyr61 Cdkn2a Ywhae Fgf4 Chd8 Cdx4 Zcchc12 Kcnip4 Med12 T Ruvbl2 Cacna1g Tle2 Tle4 Ccnd1 Mitf Ar Incenp Myc Cul1 Adcy7 Tert Mmp2 Hdac1l Ncoa2 Vcan Axin2 Skp1 PDGFR-BETA SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PDGFR-BETA SIGNALING PATHWAY PDGFR-beta signaling pathway Pik3cg Ptpn2 Fgr Cbl Grb10 Ptprj Blk Pik3r6 Iqgap1 Crk Brk1 Abi1 Yes1 Baiap2 Rac1 Bcar1 Prkca Actr3 Actr2 Arhgdia Nckap1 Arpc3 Pak1 Arpc4 Arpc5 Arpc2 Arpc1b Mapk9 Rhoa Cttn Prkcd Dnm2 Rap1b Srf Sphk1 Jund Lrp1 LOC364561 Actn4 Arap1 Mapk10 Ywhae Pdgfb Pdgfrb LOC100909750 Pik3cb Slc9a3r2 Myc Map2k4 Abl1 Pin1 Arhgap35 Slc9a3r1 Map2k1 Hck Sipa1 Myocd Stat3 Rasa1 Rab4a S1pr1 Eif2ak2 Hras Tagln Elk1 Stat1 Sos1 Mapk1 Mapk8 Src Pten Kras Sfn Raf1 Fos Dok1 Jun Gab1 Ywhaz Shc1 Ywhab Vav2 Nras Ywhag Ywhah Csk Ppp2ca Ppp2r1a Lck Ksr1 Pla2g4a Rps6ka3 Plcg1 Usp6nl Eps8 Ptpn1 Fyn Rap1a Nck2 Map2k7 Map2k2 Pik3r1 Stat5a Lyn Grb2 Ptpn11 Nck1 Stat5b S1P4 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P4 PATHWAY S1P4 pathway Mapk1 Gnai2 Gnao1 Gnai3 Gnai1 Gnaz Gna13 Gna12 Rhoa S1pr5 Plcg1 S1pr4 GLYPICAN PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN PATHWAY Glypican pathway Gpc2 JNK SIGNALING IN THE CD4+ TCR PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%JNK SIGNALING IN THE CD4+ TCR PATHWAY JNK signaling in the CD4+ TCR pathway Mapk8 Crkl Map2k4 Jun Lat Prkcb Map3k7 Map3k8 Lcp2 LOC100912399 Crk Map3k1 LOC100911248 Dbnl Map4k1 PLK1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLK1 SIGNALING EVENTS PLK1 signaling events Ect2 Gorasp1 Cdc20 Cdc14b Kif2a Tpt1 Cenpu Bub1b Bora Stag2 Plk1 Btrc Fbxo5 Rab1a Kiz Tubg1 Cdc25b Cdc25c Ppp1cb Fzr1 Cenpe Fbxw11 Bub1 Ndc80 Rock2 Incenp Sgol1 Pak1 Wee1 Kif20a Tpx2 Rhoa Golga2 Ppp1r12a Aurka Ninl Ppp2ca Spc24 Cdk1 Clspn Ercc6l Ppp2r1a Prc1 REGULATION OF CDC42 ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF CDC42 ACTIVITY Regulation of CDC42 activity Git1 Plcg1 Arhgef6 LOC100912512 Ngef Dock6 Dnmbp Vav3 Mcf2l Ralbp1 Arhgap1 Spata13 Nme1 Dock11 Itsn2 Arhgap17 Bcar3 Arhgef25 Fgd1 Arhgdia Racgap1 Vav2 Apc Arhgef7 Itsn1 Farp2 FC-EPSILON RECEPTOR I SIGNALING IN MAST CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FC-EPSILON RECEPTOR I SIGNALING IN MAST CELLS Fc-epsilon receptor I signaling in mast cells Dusp1 Cbl Prkcb Mapk1 Mapk8 Raf1 Fos Dok1 Nfkb1 Jun Ptk2 Chuk Pak2 Shc1 Fcgr2b Rela Cblb Fer Ikbkb Syk Nfatc2 Ppap2a Sphk1 Pla2g4a Lat Plcg1 Fyn Lcp2 Pxn Akt1 Map2k7 Gab2 Map2k4 Pld2 Map2k2 Map2k1 Pik3r1 Rasa1 S1pr1 Hras Wipf1 Lyn Grb2 LOC100912399 Lat2 Ptpn11 Pla2g1b Vav1 Map3k1 Hcls1 Itk Sos1 Fcer1a Ptpn13 BETA1 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA1 INTEGRIN CELL SURFACE INTERACTIONS Beta1 integrin cell surface interactions Vtn Itga7 Itga6 Mdk Itga5 Col18a1 Col11a1 Col11a2 Col4a1 Lama1 Col4a3 Col5a2 Itga4 Fn1 Col4a5 Col5a1 Itga11 Vegfa Col6a2 Itga10 Col6a1 Col3a1 Itga8 Itgb1 LOC100911572 Thbs2 Igsf8 Lamb1 Cd81 Lamb3 Lamb2 Nid1 Fbn1 Plau Lamc2 Cd14 Lamc1 Cspg4 Lama4 Spp1 F13a1 Tgm2 Itga3 Vcam1 Col1a2 Col1a1 Fga Fgb Fgg NONCANONICAL WNT SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NONCANONICAL WNT SIGNALING PATHWAY Noncanonical Wnt signaling pathway Arrb2 Mapk10 Wnt5a Cthrc1 Yes1 Prkcz Mapk8 Rac1 Ror2 Dvl3 Camk2a Daam1 Fzd6 Tab2 Fzd5 Fzd2 Map3k7 Chd7 Flna Csnk1a1 Mapk9 Nlk Rock1 Dvl1 Rhoa Nfatc2 Pparg CXCR3-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CXCR3-MEDIATED SIGNALING EVENTS CXCR3-mediated signaling events Mapkap1 Gnai2 Gnai1 Gnaz Pik3cb Akt1 Gnb1 Gnao1 Ccl11 Mapk1 Gnai3 Src Kras Map2k6 Cxcl11 Cxcl13 Raf1 Cxcr3 Arrb1 Pf4 Rictor Cxcl10 Cxcl9 Map2k2 Mapk11 Map2k1 Pdpk1 Pik3r1 Nras Mlst8 Hras Mapk14 Dnm1 Mtor NEUROTROPHIC FACTOR-MEDIATED TRK RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NEUROTROPHIC FACTOR-MEDIATED TRK RECEPTOR SIGNALING Neurotrophic factor-mediated Trk receptor signaling Crkl Crk LOC100911248 Prkcz Mapk1 Rac1 Kras Gab1 Ntrk1 Ngf Shc1 Ngfr Nras Gipc1 Rhoa Sqstm1 Prkci Maged1 Tiam1 Rit1 Rit2 Rap1b Plcg1 Ntf4 Ehd4 Ntf3 Rap1a LOC100909750 Mcf2l Ccnd1 Dynlt1 Matk Faim Rgs19 Rhog Gab2 Shc3 Abl1 Shc2 Map2k1 Pik3r1 LOC100909609 Bdnf Stat3 Dock1 Rasa1 Hras Dnaja3 Frs2 Grb2 Frs3 Ptpn11 Dnm1 Ntrk3 Ntrk2 Sos1 AURORA C SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AURORA C SIGNALING Aurora C signaling Incenp Aurkb CELLULAR ROLES OF ANTHRAX TOXIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CELLULAR ROLES OF ANTHRAX TOXIN Cellular roles of Anthrax toxin Mapk1 Map2k1 Map2k6 Pgr Casp1 Map2k4 Vcam1 Il1b Antxr1 Map2k2 Il18 Map2k7 SIGNALING EVENTS MEDIATED BY TCPTP%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY TCPTP Signaling events mediated by TCPTP Ptpn2 Ptpn1 Pdgfb Csf1r Pdgfrb Pik3cb Hgf Atr Csf1 Crebbp Src Kpna2 Jak1 Ins2 Egfr Gab1 Vegfa Shc1 Pias1 Kpnb1 Pik3r1 Stat3 Stat5a Jak3 Stat6 Rab4a Lman1 Insr Eif2ak2 Grb2 Itgb1 Stat1 Stat5b Sos1 INSULIN-MEDIATED GLUCOSE TRANSPORT%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INSULIN-MEDIATED GLUCOSE TRANSPORT Insulin-mediated glucose transport Prkcz Ppp1r3a Sfn Gys1 Ins2 Rhoq Stxbp4 Ywhaz Ywhae Ywhab Ppp1cc Stx4 Gsk3b Insr Ywhag Ywhah Akt2 Vamp2 Prkci Akt1 Slc2a4 RAS SIGNALING IN THE CD4+ TCR PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RAS SIGNALING IN THE CD4+ TCR PATHWAY Ras signaling in the CD4+ TCR pathway Mapk1 Ptpn7 Map2k1 Kras Map3k8 Raf1 Prkca Nras Fos Hras Elk1 Prkcb COREGULATION OF ANDROGEN RECEPTOR ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%COREGULATION OF ANDROGEN RECEPTOR ACTIVITY Coregulation of Androgen receptor activity Brca1 Carm1 Med1 Vav3 Nkx3-1 Kdm3a Snurf Fkbp4 Ncoa6 Tgfb1i1 Tmprss2 Ncoa4 Lats2 Svil Mak Hip1 Tcf4 Prkdc Zmiz1 Tgif1 Cdk6 Zfp318 Prdx1 Pa2g4 Ccnd3 Pawr Srf Ptk2b Rps6ka3 Gsn Cdkn2a Xrcc5 Casp8 Xrcc6 Ube2i Pias4 Ctdsp1 Ccnd1 Akt1 Pelp1 Fhl2 Ube3a Ar Pias3 Kdm1a Pias1 Nrip1 Uba3 Ncoa2 VISUAL SIGNAL TRANSDUCTION: CONES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VISUAL SIGNAL TRANSDUCTION: CONES Visual signal transduction: Cones Rpe65 Gucy2f Cngb3 Gnat2 Pde6c Gngt2 Slc24a2 Gnb3 Guca1b Gnb5 Rgs9 Pde6h Rgs9bp Grk1 Guca1a Arr3 Lrat Gucy2d THROMBOXANE A2 RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%THROMBOXANE A2 RECEPTOR SIGNALING Thromboxane A2 receptor signaling Ptgdr Tbxa2r Pik3cg Ptgir Fgr Ptgdrl Sele Prkch Prkcb Gnb5 Blk Pik3r6 Plcb2 Yes1 Prkcz Src Rac1 Gna15 Gna14 Prkca Gna13 Gna12 Gna11 Gnaq Rab11a Prkcq Rock1 Prkaca Mapk14 Rhoa Syk Prkcd Arrb2 Lck Fyn Gnai2 Adrbk1 Arr3 Tgm2 Vcam1 Akt1 Gnb1 Egfr Mapk11 Slc9a3r1 Nos3 Hck Icam1 Lyn Dnm1 ALK2 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALK2 SIGNALING EVENTS ALK2 signaling events Smad1 Acvr1 Bmp7 Bmpr2 Amh Smad5 Amhr2 Fkbp1a A6B1 AND A6B4 INTEGRIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%A6B1 AND A6B4 INTEGRIN SIGNALING a6b1 and a6b4 Integrin signaling Lamb1 Lamb3 Lamb2 Lamc2 Lamc1 Ywhae Itga6 Itgb4 Lama4 Akt1 Rac1 Sfn Prkca Mst1r Lama1 Erbb3 Il1a Col17a1 Egfr Pmp22 Mst1 Ywhaz Cdh1 Shc1 Rps6kb1 Rxrg Ywhab Pik3r1 Rxrb Erbb2 Hras Rxra Ywhag Ywhah Grb2 Itgb1 P38 SIGNALING MEDIATED BY MAPKAP KINASES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P38 SIGNALING MEDIATED BY MAPKAP KINASES p38 signaling mediated by MAPKAP kinases Creb1 Sfn Raf1 Srf Mapkapk2 Ywhaz Cdc25b Mapk11 Hspb1 Mapkapk3 Ywhae Lsp1 Ywhab Etv1 Th Tsc2 Ywhag Ywhah Mapk14 POLO-LIKE KINASE SIGNALING EVENTS IN THE CELL CYCLE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%POLO-LIKE KINASE SIGNALING EVENTS IN THE CELL CYCLE Polo-like kinase signaling events in the cell cycle Plk4 Plk2 Plk1 Plk3 IL4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL4-MEDIATED SIGNALING EVENTS IL4-mediated signaling events Cbl Fes Thy1 aicda Fcer2 Socs1 Mybl1 Dok2 Il4r Socs5 Irs2 Shc1 Il4 Bcl2l1 Mapk14 Ets1 Cd40lg Il2rg Selp Arg1 Il13ra1 Il13ra2 Sp1 Retnlg Tff3 Il10 Parp14 Oprm1 Lta Hmga1 Pigr LOC100360218 Akt1 Ccl17 Egr2 Alox15 Ccl11 Jak1 Col1a2 Col1a1 Bcl6 Rps6kb1 Pik3r1 Spi1 Stat5a Stat6 Jak3 Ptpn6 Grb2 Irs1 Stat5b Il5 Mtor Socs3 EPHRINB-EPHB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRINB-EPHB PATHWAY EphrinB-EPHB pathway Ephb2 Efnb1 Efnb2 Ephb3 Ephb1 TGF-BETA RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TGF-BETA RECEPTOR SIGNALING TGF-beta receptor signaling Zfyve9 Arrb2 Wwp1 Dact2 Tgfbr1 Strap Ppp1r15a Ppp1ca Ppp2r2a Dab2 Xiap Smad7 Tgfb3 Bambi Zfyve16 Sptbn1 Ywhae Ppp2cb Smad2 Eif2a Smurf1 Tgfbr3 Daxx Dynlrb1 Ctgf Pml Tgfbr2 Camk2a Tab2 Shc1 Pard6a Rps6kb1 Map3k7 Tgfb1 Pdpk1 Grb2 Fkbp1a Ppp2ca Smad3 Sos1 SIGNALING MEDIATED BY P38-ALPHA AND P38-BETA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING MEDIATED BY P38-ALPHA AND P38-BETA Signaling mediated by p38-alpha and p38-beta Ptgs2 Ppargc1a Pla2g4a Mapkapk2 Slc9a1 Mef2c Atf1 Rps6ka5 Esr1 Ddit3 LOC497963 Creb1 Hbp1 Eif4ebp1 Atf2 Mitf Jun Mapk11 Hspb1 Mapkapk3 Krt8 Mapk14 Atf6 Mknk1 Elk4 Tp53 Mapkapk5 Usf1 VALIDATED TRANSCRIPTIONAL TARGETS OF AP1 FAMILY MEMBERS FRA1 AND FRA2%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TRANSCRIPTIONAL TARGETS OF AP1 FAMILY MEMBERS FRA1 AND FRA2 Validated transcriptional targets of AP1 family members Fra1 and Fra2 Ccna2 Jund Plau Gja1 Cdkn2a Sp1 Itgb4 Ccnd1 Lif Jun Col1a2 Il6 Mgp Dmtf1 Thbd Txlng Mmp9 Junb Hmox1 Mmp2 Fosl1 Mmp1 Nos3 Ccl12 Dcn Atf4 Nfatc3 Nfatc2 Bglap SYNDECAN-1-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-1-MEDIATED SIGNALING EVENTS Syndecan-1-mediated signaling events Fgfr4 Fgf19 Fgfr3 Fgf23 Hgf Hpse Mapk1 Col11a1 Ppib Col11a2 Bsg Col4a1 Col4a3 Col5a2 Col1a2 Col4a5 Col5a1 Col1a1 Col6a2 Mmp9 Col6a1 Ccl5 Col3a1 Mmp1 Tgfb1 Sdcbp Mmp7 Prkaca LOC100911572 IFN-GAMMA PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IFN-GAMMA PATHWAY IFN-gamma pathway Rap1b Ptpn2 Crkl Cbl Smad7 Map3k11 Rap1a Pias4 Akt1 LOC100911248 Ifng Mapk1 Crebbp Socs1 Jak1 Irf9 Ptges2 Camk2a Pias1 Map2k1 Ifngr1 Pik3r1 Stat3 Casp1 Dapk1 Irf1 LOC100912399 Ptpn11 Map3k1 Stat1 Camk2d Il1b Prkcd Camk2g Mtor SYNDECAN-2-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-2-MEDIATED SIGNALING EVENTS Syndecan-2-mediated signaling events Fgfr4 Fgf19 Fgfr3 Sdc2 Fgf23 Ezr Trappc4 Cav2 Epb4.1 Nf1 Mapk1 Src Mapk8 Casp3 Lama1 Fn1 Mmp2 Tgfb1 Sdcbp Csf2 Rasa1 Ephb2 Hras Prkaca Rhoa Itgb1 Prkcd Bax TRAIL SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TRAIL SIGNALING PATHWAY TRAIL signaling pathway Mapk1 Mapk8 Traf2 Map2k4 Smpd1 Cflar Chuk Casp8 Tradd Pik3r1 Dap3 Tnfsf10 Ikbkb Pik3cb LOC100912399 Map3k1 Ripk1 Fadd VALIDATED NUCLEAR ESTROGEN RECEPTOR BETA NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED NUCLEAR ESTROGEN RECEPTOR BETA NETWORK Validated nuclear estrogen receptor beta network Esr2 Ube2m Zfp709 Smarce1 Smarcb1 Nr0b2 Nedd8 Nr0b1 C3 Uba3 Ncoa2 Ncoa1 Ddx54 Smarca4 SUMOYLATION BY RANBP2 REGULATES TRANSCRIPTIONAL REPRESSION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SUMOYLATION BY RANBP2 REGULATES TRANSCRIPTIONAL REPRESSION Sumoylation by RanBP2 regulates transcriptional repression Ran Pias2 Hdac4 Hdac1 Mdm2 Hdac1l Xpo1 Ube2i Pias1 Ranbp2 CASPASE CASCADE IN APOPTOSIS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CASPASE CASCADE IN APOPTOSIS Caspase cascade in apoptosis Birc2 Parp1 Apaf1 Tnfrsf1a Xiap Diablo Gsn Bid Tradd Casp8 Ripk1 Cfl2 Birc3 LOC100911519 Krt18 Cradd Limk1 Numa1 Sptan1 Casp3 Traf2 Tfap2a Madd Lmna Srebf1 Gas2 Top1 Arhgdib Dffb Acta1 Ptk2 Lmnb2 Dffa Satb1 Lmnb1 Casp2 Casp6 Casp4 Casp9 Casp1 Vim App Pidd1 LOC100912399 Cycs Map3k1 Bax Bcl2 THROMBIN PROTEASE-ACTIVATED RECEPTOR (PAR) PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%THROMBIN PROTEASE-ACTIVATED RECEPTOR (PAR) PATHWAY Thrombin protease-activated receptor (PAR) pathway F2 IL12-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL12-MEDIATED SIGNALING EVENTS IL12-mediated signaling events Tbx21 Il18r1 Lck Ripk2 Il12rb2 Faslg Ccl4 B2m Nfkb2 Ccr5 Il1r1 Sphk2 Hlx Cd8b Il12a Cd8a Il2rg Il12b Cd3e Gzma Cd247 Cd3d RT1-Da RT1-Db1 Cd3g Ifng LOC497963 Socs1 Map2k6 Atf2 Fos Nfkb1 Gadd45g Gadd45b Cd4 Rab7a Il4 Stat3 Stat5a Rela Stat6 Il2ra Mapk14 Stat1 Il1b Mtor Il18 Il2 S1P2 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P2 PATHWAY S1P2 pathway Gnao1 S1pr2 Mapk1 Gnai3 Rac1 Mapk8 Gna15 Cdh5 Gna14 Gna13 Fos Gna12 Gna11 Gnaq Jun Pak1 Gnai2 Gnai1 Gnaz Elk1 Rhoa Mapk14 Irs1 SPHINGOSINE 1-PHOSPHATE (S1P) PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SPHINGOSINE 1-PHOSPHATE (S1P) PATHWAY Sphingosine 1-phosphate (S1P) pathway Gnao1 S1pr2 Gnai3 Gna15 Gna14 Gna13 Gna12 Gna11 Gnaq Sphk1 S1pr3 Sphk2 Gnai2 Sgpl1 Gnai1 LOC688708 Gnaz S1pr1 S1pr5 S1pr4 RHOA SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RHOA SIGNALING PATHWAY RhoA signaling pathway Srf Vcl Pip5k1c Limk2 Cyr61 Slc9a1 Tln1 Diaph1 Ezr Rdx Prkcz Limk1 Mkl1 Mapk8 Cfl1 Pten Cit Map2k6 Pkn2 Atf2 Fos Rock2 Map2k4 Jun Acta1 Pip5k1b Pld2 Pard6a Pld1 F2rl2 Sh3gl2 Slc9a3 Rock1 Cdkn1b Rhoa Ppp1r12a Itgb1 Scai Pkn1 Mapk12 Msn VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL ACTIVATION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL ACTIVATION Validated targets of C-MYC transcriptional activation Mta1 Cdc25a Kat5 Id2 Nbn Crebbp Nme1 Mmp9 Fosl1 Mtdh Cdk4 Actl6a Snai1 Serpini1 Ireb2 Prdx3 Rpl11 Lin28b LOC100911431 Slc2a1 Bcat1 Ruvbl1 Hspa4 Polr3d Hspd1 Odc1 Eif4g1 Eif2s1 Myct1 Supt7l Pdcd10 Ubtf Cad Shmt1 Ddx18 LOC680559 Bmi1 Gpam Tfrc Ruvbl2 E2f3 Hmga1 Kat2a Max Taf9 Myc Eno1 Tert Eif4a1 LOC103692716 Tp53 Smad3 Bax Npm1 Pim1 C-MYB TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%C-MYB TRANSCRIPTION FACTOR NETWORK C-MYB transcription factor network Kit Ccna1 Tom1 Trim28 Cdkn1a Myf6 Anpep LOC100363915 Hipk2 H2afz Gata1 Cd34 LOC100911167 Smarca2 Atp2b1 Csf1r Iqgap1 Crebbp Kras Lef1 Tab2 Ppp3ca Map3k7 Casp6 Nras Cdk6 Ets1 Bcl2 Snd1 Ptgs2 Elane Kitlg Mat2a Lect2 Zfhx3 Ets2 Yeats4 Gstm7 Mpo Cbx4 Cebpa LOC100911324 Slc25a3 Maf Car1 Ppidl1 Cdkn2a Sp1 Rag2 Ube2i Adora2b Ccnd1 Ada Mcm4 Prtn3 Birc3 Mad1l1 Sin3a Gata3 Myc Col1a2 Hes1 Pias3 Wnt1 Clta Cd4 Ptcra Spi1 Nlk Hras Cdkn1b Myod1 Pim1 CD40 CD40L SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CD40 CD40L SIGNALING CD40 CD40L signaling Pik3cg Cd40lg Birc2 Traf3 Mapk10 Cd40 Tdp2 Fcamr Map3k14 C4bpa Pik3r6 Pik3cb Akt1 Birc3 Mapk8 Traf2 Nfkb1 Map2k4 Myc Jun Mapk11 Pik3r1 Il4 Stat5a Rela Jak3 Cblb Mapk9 Mapk14 LOC100912399 Bcl2l1 Traf6 Map3k1 Nfkbia REGULATION OF RAS FAMILY ACTIVATION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RAS FAMILY ACTIVATION Regulation of Ras family activation Nf1 Rabgef1 Prkcz Syngap1 Kras Rras Lgals3 Prkca Lgals1 Prkcb Rasgrp2 Rin1 Rasgrp1 LOC100911794 Rasa1 Nras Hras Grb2 Rasgrp3 Rasal1 Rasgrp4 Sos1 Plce1 Rasa2 ALPHAE BETA7 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHAE BETA7 INTEGRIN CELL SURFACE INTERACTIONS AlphaE beta7 integrin cell surface interactions Itgb7 Cdh1 IL2 SIGNALING EVENTS MEDIATED BY STAT5%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL2 SIGNALING EVENTS MEDIATED BY STAT5 IL2 signaling events mediated by STAT5 Ccna2 Lck Faslg Il2rg Sp1 Lta Jak1 Gab2 Myc Shc1 Il4 Pik3r1 Elf1 Stat5a Jak3 Foxp3 Il2ra Cdk6 Bcl2l1 Grb2 Ptpn11 Sos1 Stat5b Ccnd3 Bcl2 Il2 FOXO FAMILY SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXO FAMILY SIGNALING FoxO family signaling Cdk2 Sgk1 Zfand5 Cat Rbl2 Fbxo32 Csnk1g1 Faslg Csnk1g2 Plk1 Mapk10 Ralb Ywhae Rala Sod2 Csnk1d Csnk1g3 Csnk1e Usp7 Akt1 Crebbp Mapk8 Sfn G6pc Xpo1 Mst1 Chuk Gadd45a Ywhaz Bcl6 Ran Foxo3 Ywhab Csnk1a1 Mapk9 Ywhag Ywhah Cdkn1b Skp2 Foxo4 Ikbkb Bcl2l11 Foxo1 SIGNALING EVENTS MEDIATED BY HDAC CLASS II%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HDAC CLASS II Signaling events mediated by HDAC Class II Srf Gata1 Mef2c LOC100911167 Ranbp2 Ywhae Esr1 LOC100360129 Ankra2 Hdac6 Rfxank Ube2i Adrbk1 Gnb1 Hdac3 Camk4 Hdac4 Xpo1 LOC100910438 Hdac11 Hdac10 Gata2 Bcl6 Ran Ywhab Tubb2a Ncor2 LOC103692716 CIRCADIAN RHYTHM PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CIRCADIAN RHYTHM PATHWAY Circadian rhythm pathway Atr Stt3a Timeless Wdr5 Bhlhe40 Nr1d1 LOC100911602 Npas2 Cry1 Per2 Nono Csnk1e Clock Arntl Cry2 Per1 P73 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P73 TRANSCRIPTION FACTOR NETWORK p73 transcription factor network Mdm2 Hey2 Stt3a Ccna2 LOC100911267 Cdkn1a Kat5 Plk1 Tp73 Rad51 Bak1 Gata1 LOC100911167 Plk3 Serpine1 Sfn Il4r Ntrk1 Casp2 Foxo3 Rela Cdk6 Bin1 Tp63 Mapk14 Bcl2l11 Cdk1 Cdk2 Ppap2a LOC364561 Dedd Gramd4 Nsg1 Aen Sp1 Ndufs2 Ccne2 Serpina1 Pea15 Afp LOC100909750 Dcp1b Pfdn5 Hsf1 Flot2 Rchy1 Ada Rnf43 Ube4b Fas Il1rap Hagh Prkacb Brca2 Bub1 Jak1 Pml Clca2 Myc Abl1 Mapk11 Pin1 Gdf15 Wt1 Rb1 Bax CANONICAL WNT SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CANONICAL WNT SIGNALING PATHWAY Canonical Wnt signaling pathway Cul3 Csnk1g1 Dvl3 Klhl12 Wnt3 Ranbp3 Nkd2 Pip5k1b Wnt3a Ppp2r5a Fzd5 Gsk3a Pi4k2a Gsk3b Lrp6 Apc Dvl1 BMP RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BMP RECEPTOR SIGNALING BMP receptor signaling Chrdl1 Grem1 Rgma Hfe2 Bmp6 Bmp2 Sostdc1 Nog Ppp1r15a Ppp1ca Xiap Smad7 Bambi Zfyve16 Smad1 Smurf1 Bmp7 Bmpr2 Smad5 Ctdsp1 Ctdspl Mapk1 Tab2 Bmp4 Map3k7 Gsk3b Smad6 Chrd Fst ALK1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALK1 PATHWAY ALK1 pathway Acvr1 Acvrl1 Fkbp1a VALIDATED TRANSCRIPTIONAL TARGETS OF TAP63 ISOFORMS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TRANSCRIPTIONAL TARGETS OF TAP63 ISOFORMS Validated transcriptional targets of TAp63 isoforms Wwp1 Mdm2 Shh Cdkn1a Plk1 Btrc Cdkn2a Aen Perp Sp1 Itgb4 Gpx2 Nqo1 LOC100909750 Ssrp1 Traf4 Itga3 Spata18 Flot2 Evpl Ada Dicer1 Fas Dhrs3 Tfap2c Egr2 Noc2l Mfge8 Ogg1 Hbp1 Smarcd3 Igfbp3 Pml Clca2 Serpinb5 Abl1 Chuk Gadd45a Gdf15 Cables1 Vdr Ikbkb Tp63 Prkcd Jag1 Bax Fdxr GLUCOCORTICOID RECEPTOR REGULATORY NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLUCOCORTICOID RECEPTOR REGULATORY NETWORK Glucocorticoid receptor regulatory network Hdac2 Hdac1 Mdm2 Tbx21 Sele Cdk5 Tbp Cdkn1a Nr4a1 Smarca4 Mapk1 Mapk8 Crebbp Sfn Fkbp4 Fos Nfkb1 Jun Egr1 Il13 Smarcc2 Mmp1 Fkbp5 Il4 Tsg101 Nr1i3 Suv420h1 Csf2 Csn2 Gsk3b Rela Pou1f1 Mapk9 Smarcc1 Ywhah Cga Prkaca Ncoa1 Krt17 Mapk14 Krt14 Smarcd1 Pou2f1 Sgk1 Ppp5c Pomc Mapk10 Afp Cdk5r1 Akt1 Ifng Prkacb Creb1 Gata3 Il6 Mapk11 Spi1 Stat5a Icam1 Hdac1l Prl Irf1 Ncoa2 Fgg LOC103692716 Tp53 Stat1 Bglap Stat5b Bax Il5 Il2 EPHRIN A REVERSE SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRIN A REVERSE SIGNALING Ephrin A reverse signaling Fyn REGULATION OF ANDROGEN RECEPTOR ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF ANDROGEN RECEPTOR ACTIVITY Regulation of Androgen receptor activity Pou2f1 Hdac1 Mdm2 Carm1 Kat5 Smarce1 Cebpa Hoxb13 Dnaja1 Senp1 Smarca2 Appbp2 Trim24 Kat7 Ehmt2 Pde9a Zmiz2 Nr2c2 Nr2c1 Spdef Rchy1 Mapk8 Crebbp Src Map2k6 Tmprss2 Ar Map2k4 Jun Gata2 Egr1 Rxrg Nr0b1 Gsk3b Hdac1l Rxrb Smarcc1 Rxra Ncoa2 Ncoa1 Mapk14 LOC103692716 Foxo1 Pkn1 BETA3 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA3 INTEGRIN CELL SURFACE INTERACTIONS Beta3 integrin cell surface interactions L1cam Cd47 Sphk1 Lamb1 Vtn Ibsp Cyr61 Fbn1 Plau Lamc1 Pdgfb Pdgfrb Itga2b Spp1 Thy1 Lama4 Sdc4 Col4a1 Col4a3 Fn1 Tgfbr2 Col1a2 Col4a5 Vegfa Col1a1 Fga Fgb Fgg F11r LOC100911572 EPHRINA-EPHA PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRINA-EPHA PATHWAY EphrinA-EPHA pathway Epha8 Epha7 Epha4 Epha3 Epha2 DEGRADATION OF BETA CATENIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DEGRADATION OF BETA CATENIN Degradation of beta catenin Dvl3 Wnt3 Cul1 Btrc Wnt3a Fzd5 Gsk3a Gsk3b Csnk1a1 Lrp6 Apc Dvl1 Csnk1d Axin2 Skp1 Csnk1e S1P1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P1 PATHWAY S1P1 pathway Mapk1 Gnao1 Rac1 Ptgs2 Gnai3 Sphk1 Vegfa Plcg1 Gnai2 Pdgfb Gnai1 LOC688708 Pdgfrb Gnaz S1pr1 Rhoa Plcb2 REGULATION OF RHOA ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RHOA ACTIVITY Regulation of RhoA activity Ect2 Arhgef15 Arap1 Arhgef2 LOC100912512 Ngef Vav3 Mcf2l Arhgef25 Arhgef18 Arhgdia Def6 Arhgdib Farp1 Arhgef3 Arhgef5 Arhgap5 Arhgef11 Arhgef28 Arhgap35 Arhgap9 Net1 Ophn1 Srgap1 Abr Vav2 Arhgap8 Myo9b Trio Cdkn1b Rhoa Vav1 AP-1 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AP-1 TRANSCRIPTION FACTOR NETWORK AP-1 transcription factor network Dusp1 Mafg Agt Dmp1 Nppa Fabp4 Nts Mt2A Edn1 Cbfb Penk Bag1 Pten Atf2 Fos Jun Acta1 Gata2 Egr1 Mmp9 Fosl1 Mmp1 Il4 Th Csf2 Nfatc3 Ets1 Bcl2l11 Nfatc2 Cdk1 Jund Cyr61 Maf Plau Gja1 Cdkn2a Esr1 Sp1 Il10 Ccnd1 Ifng Atf3 Creb1 Myc Col1a2 Il6 Dmtf1 Timp1 Junb Tgfb1 Elf1 Ccl12 Cdkn1b Tp53 Il5 Hif1a Il2 AURORA A SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AURORA A SIGNALING Aurora A signaling Cpeb1 Ajuba Ccnl2 Brca1 Mdm2 Dlgap5 Git1 Ckap5 Ndel1 Tacc3 Cdc25b Oaz1 Fzr1 Akt1 Cenpa Gadd45a Pak1 Ran Rasa1 Gsk3b Prkaca Tpx2 Aurkb Aurka Tacc1 Arhgef7 Nfkbia Tp53 INSULIN PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INSULIN PATHWAY Insulin Pathway Sgk1 Cbl Grb10 Ptpra Ptpn1 Rhoq Exoc5 Exoc3 Crk Akt1 Nck2 Prkcz Exoc7 Eif4ebp1 Dok1 Ins2 Exoc6 Exoc2 Shc1 Rps6kb1 Pard6a F2rl2 Foxo3 Pdpk1 Pik3r1 Rasa1 Insr Hras Akt2 Grb2 Ptpn11 Sh2b2 Grb14 Prkci Nck1 Irs1 Sorbs1 Sos1 RETINOIC ACID RECEPTORS-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RETINOIC ACID RECEPTORS-MEDIATED SIGNALING Retinoic acid receptors-mediated signaling Hdac1 Akt1 Hdac3 Mapk1 Crebbp Mapk8 Prkca Rbp1 Rxrg Mnat1 Rara Ccnh Nrip1 Rxrb Hdac1l Cdk7 Rxra Vdr Ncoa2 Ncoa1 Prkaca Mapk14 Rarg Ncor2 Cdk1 IL1-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL1-MEDIATED SIGNALING EVENTS IL1-mediated signaling events Erc1 Ube2n Il1r1 Il1rap Prkcz Il1rn Map3k3 Tollip Mapk8 Map2k6 Il1r2 Ticam2 LOC100362142 Nfkb1 Il1a Jun Tab2 Chuk LOC100912618 Irak3 Irak4 Ube2v1 Map3k7 Pik3r1 Rela Casp1 Myd88 Ikbkb Sqstm1 Traf6 Prkci Il1b GLYPICAN 2 NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN 2 NETWORK Glypican 2 network Mdk Gpc2 E2F TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E2F TRANSCRIPTION FACTOR NETWORK E2F transcription factor network Cdc6 Hdac1 Brca1 Rbl2 Trim28 Ccna2 Rbbp8 Cdkn1a Cdc25a Topbp1 Apaf1 Tp73 Smarca2 Serpine1 Crebbp Hbp1 Wasf1 Cdk1 Ccnd3 Cdk2 Tfdp2 Tyms RGD1565297 Rrm2 Tfe3 Prmt5 Ces2h Mybl2 Orc1 Cebpa Cdkn2c Ces1d Sult2a1 Plau Ces5a Ces4a Cdkn2a Sp1 Ccne2 E2f3 E2f1 Kat2a Ccne1 Atm Myc Yy1 E2f6 Rbl1 Ranbp1 Xrcc1 Uxt Hdac1l E2f7 Mcm3 Dhfr E2f5 Cdkn1b Cbx5 Rb1 LKB1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LKB1 SIGNALING EVENTS LKB1 signaling events Stradb Ywhae Cab39 Esr1 Brsk1 Strada Etv4 Cdc37 Stk11 Ezr Creb1 Smarcd3 Sfn Ctsd Myc Stk11ip Mark4 Stk26 Sik1 Ywhaz Mark2 Psen2 Rptor Map2 Ywhab Gsk3b Tsc2 Mlst8 Ywhag Tsc1 Ywhah Prkaca LOC103692716 Akt1s1 Tp53 Mtor HYPOXIC AND OXYGEN HOMEOSTASIS REGULATION OF HIF-1-ALPHA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HYPOXIC AND OXYGEN HOMEOSTASIS REGULATION OF HIF-1-ALPHA Hypoxic and oxygen homeostasis regulation of HIF-1-alpha Tceb1 Os9 Hif3a Vhl Egln3 Egln2 Rbx1 Hif1an Cul2 Arnt Cdkn2a LOC103692716 Tp53 Hif1a IL23-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL23-MEDIATED SIGNALING EVENTS IL23-mediated signaling events Il18r1 Mpo Il12b Cd3e Itga3 LOC497963 Ifng Nfkb1 Il6 Cxcl9 Cd4 Pik3r1 Stat3 Il23r Ccl12 Stat5a Il19 Rela Alox12b Il24 Cxcl3 Il17f Il23a Il17a Stat1 Il1b Nfkbia Il18 Socs3 Il2 TCR SIGNALING IN NAIVE CD4+ T CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TCR SIGNALING IN NAIVE CD4+ T CELLS TCR signaling in naive CD4+ T cells Cbl Prkcb Sh3bp2 Fyb Kras Pten Stk39 Prkca Bcl10 Chuk Shc1 Ptprc Map3k8 Prkcq Nras Ikbkb Csk Sla2 Trpv6 Cd86 Orai1 Lck Stim1 Lat Plcg1 Cd28 Rassf5 Cd80 Fyn Rasgrp2 Rasgrp1 Cd3e Lcp2 Cd247 Cd3d Map3k14 Zap70 Rap1a RT1-Da RT1-Db1 Akt1 Cd3g Gab2 Cd4 Pdpk1 Flna Ptpn6 Hras Grb2 Ptpn11 Traf6 Vav1 Itk Nck1 Sos1 Dbnl Map4k1 EPO SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPO SIGNALING PATHWAY EPO signaling pathway Crkl Cbl Plcg1 Rap1a LOC100911248 Mapk8 Epo Nfkb1 Tec Gab1 Epor Irs2 Shc1 Pik3r1 Stat5a Ptpn6 Vav2 Hras Lyn Bcl2l1 Mapk14 Grb2 Ptpn11 Stat1 Sos1 Stat5b Socs3 Bcl2 HIF-1-ALPHA TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HIF-1-ALPHA TRANSCRIPTION FACTOR NETWORK HIF-1-alpha transcription factor network Ndrg1 Egln3 Arnt Hk2 Nt5e Plin2 Bhlhe41 Id2 Serpine1 Edn1 Abcg2 Cxcl12 Pgk1 Crebbp Adm Cp Aldoa Fech Fos Epo Abcb1a Lep Jun Tf Pfkfb3 Vegfa Cited2 Rora Gata2 Pgm1 Pfkl Pkm Car9 Bhlhe40 Ncoa1 Cxcr4 Ets1 Slc2a1 Hnf4a Igfbp1 Tfrc Sp1 Tff3 Itgb2 Akt1 LOC497963 Creb1 Bnip3 Eno1 Tert Hmox1 Furin Ncoa2 Smad3 Npm1 Hif1a LPA4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LPA4-MEDIATED SIGNALING EVENTS LPA4-mediated signaling events Creb1 Adcy3 Lpar4 Adcy8 Prkaca Adcy7 Adcy5 Gnal Adcy4 Adcy6 Rps6ka5 NEPHRIN NEPH1 SIGNALING IN THE KIDNEY PODOCYTE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NEPHRIN NEPH1 SIGNALING IN THE KIDNEY PODOCYTE Nephrin Neph1 signaling in the kidney podocyte Arrb2 Trpc6 Plcg1 Fyn Mapk10 Kirrel Pik3cb Tjp1 Nphs1 Nphs2 Akt1 Nck2 Prkcz Mapk8 Rac1 Map2k4 Jun Pard6a Bad F2rl2 Pik3r1 Mapk9 Grb2 Nck1 Prkci Cd2ap ARF6 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF6 SIGNALING EVENTS Arf6 signaling events Arrb2 Efna1 Lhcgr Gulp1 Acap2 Fbxo8 Kif13b Git1 Cyth3 Itga2b Acap1 Pxn Hgf Epha2 Tshr Src Cyth2 Gna15 LOC100360745 Gna14 Arrb1 Agtr1a Gna11 Gnaq Egfr Arf6 Nck1 Adrb2 PAR1-MEDIATED THROMBIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PAR1-MEDIATED THROMBIN SIGNALING EVENTS PAR1-mediated thrombin signaling events Trpc6 Snx2 Prkcb F2r Gnai2 Gnai1 Vasp Gnaz Zyx Plcb2 F2 Gnb1 Gnao1 Gnai3 Plcb3 Gna15 Gna14 Plcb1 Prkca Gna13 Arrb1 Gna12 Gna11 Rock2 Gnaq Arhgdia F2rl2 Nos3 Pik3r1 Rock1 Rhoa Dnm1 Prkcd Pkn1 Snx1 Dnm2 E-CADHERIN SIGNALING IN THE NASCENT ADHERENS JUNCTION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E-CADHERIN SIGNALING IN THE NASCENT ADHERENS JUNCTION E-cadherin signaling in the nascent adherens junction Rap1b Pip5k1c Ctnnd1 Dlg1 Itgb7 Enah Rap1a Iqgap1 Tjp1 Crk Abi1 Ccnd1 Akt1 Rac1 Src Nme1 Nckap1 Cdh1 Arf6 Pik3r1 Klhl20 Ap1m1 Vav2 Jup Rhoa Cttn Ctnna1 Tiam1 PRESENILIN ACTION IN NOTCH AND WNT SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PRESENILIN ACTION IN NOTCH AND WNT SIGNALING Presenilin action in Notch and Wnt signaling Aph1b Hdac1 Tle1 Btrc Psenen Dkk1 Ctbp1 Ncstn Psen1 LOC100911293 Fbxw11 Ccnd1 Mapk1 Crebbp Notch1 Csnk2a1 Fzd1 Hnf1a Fos Kremen2 Myc Jun Wnt1 Aes Wif1 Dkk2 Map3k7 Nkd1 Ppard Hdac1l Gsk3b Csnk1a1 Nlk Apc Lrp6 Dvl1 ALK1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALK1 SIGNALING EVENTS ALK1 signaling events Id1 Arrb2 Mapk1 Tgfbr2 Tgfbr1 Acvrl1 Ppp1ca Smad7 Tgfb3 Tgfb1 Smad1 Acvr1 Bmpr2 Smad5 Acvr2a Gdf2 Csnk2b Fkbp1a Inhba Acvr2b CLASS I PI3K SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CLASS I PI3K SIGNALING EVENTS Class I PI3K signaling events Pik3cg Sgk1 Fgr Lck Plcg1 Lat Cyth3 Fyn Blk Zap70 Rap1a Pik3r6 Pik3cb Yes1 Arf5 Src Rac1 Cyth1 Cyth2 Kras Pten Plekha1 Arf6 Foxo3 Hck Blnk Pdpk1 Pik3r1 Nras Hras Dapp1 Lyn Rhoa Syk LOC103692716 Itk E-CADHERIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E-CADHERIN SIGNALING EVENTS E-cadherin signaling events Jup Cdh1 CLASS IB PI3K NON-LIPID KINASE EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CLASS IB PI3K NON-LIPID KINASE EVENTS Class IB PI3K non-lipid kinase events Mapk1 Pik3cg Map2k1 Pde3b Pik3r6 IL27-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL27-MEDIATED SIGNALING EVENTS IL27-mediated signaling events Jak1 Tbx21 Gata3 Il12rb2 Il6 Il27ra Il12a Ebi3 Il12b Tgfb1 Stat3 Stat5a Il6st Il17a Il1b Stat1 Il18 Ifng Stat2 Il2 PLK2 AND PLK4 EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLK2 AND PLK4 EVENTS PLK2 and PLK4 events Plk4 Plk2 PDGF RECEPTOR SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PDGF RECEPTOR SIGNALING NETWORK PDGF receptor signaling network Pdgfb Pdgfrb Pdgfra Pdgfa Pdgfc E-CADHERIN SIGNALING IN KERATINOCYTES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E-CADHERIN SIGNALING IN KERATINOCYTES E-cadherin signaling in keratinocytes Rac1 Src Ajuba Egfr Ctnnd1 Plcg1 Cdh1 Fyn Pik3r1 Vasp Zyx Casr Jup Akt2 Rhoa Akt1 Ctnna1 SIGNALING EVENTS MEDIATED BY PRL%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY PRL Signaling events mediated by PRL Mapk1 Cdk2 Ccne1 Rac1 Src Bcar1 Ccna2 Cdkn1a Egr1 Rhoc Ptp4a3 Agt Rock1 Rhoa Itgb1 Rabggta Rabggtb Atf5 Ptp4a1 REGULATION OF NUCLEAR SMAD2 3 SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF NUCLEAR SMAD2 3 SIGNALING Regulation of nuclear SMAD2 3 signaling Hdac2 Hdac1 Cdkn1a Zbtb17 Smad7 Ctbp1 Smad2 Serpine1 Cbfb Crebbp Atf2 Fos Jun Tgif1 Foxo3 Cdk4 Vdr Foxg1 Ncoa1 Nkx2-5 Med15 Snip1 Foxh1 Skil Dcp1a Gsc Cdk2 Hnf4a Tfe3 Ifnb1 Runx1 Cited1 Runx3 Dlx1 Irf7 Mef2c Lamc1 Esr1 Sp1 Il10 Pias4 Akt1 Kat2a Atf3 Creb1 Sin3a Max Gata3 Ar Myc Col1a2 Pias3 Rbl1 Rbbp7 RGD1561590 Hdac1l Cdkn2b Sap18 E2f5 Ncoa2 Foxo4 Myod1 Runx2 Smad3 Foxo1 Il5 IL2-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL2-MEDIATED SIGNALING EVENTS IL2-mediated signaling events Mapkapk2 Prkcb Mapk1 Mapk8 Kras Socs1 Raf1 Fos Dok2 Jun Irs2 Shc1 Stam2 Ikzf3 Nras Mapk9 Stam Mapk14 Rhoa Syk Bcl2 Cdk2 Lck Ptk2b Fyn Il2rg Ifng Jak1 Gab2 Myc Map2k2 Mapk11 Cish Map2k1 Pik3r1 Stat3 Stat5a Rasa1 Jak3 Il2ra Hras Grb2 Ptpn11 Stat1 Irs1 Stat5b Sos1 Il2 Socs3 AMB2 INTEGRIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AMB2 INTEGRIN SIGNALING amb2 Integrin signaling Rap1b Lrp1 Tln1 Plau Selp Thy1 Jam3 Ctgf Plat Rap1a Itgb2 Itgam Mst1r Plg Nfkb1 Il6 Mst1 Apob Selplg Ager Mmp9 Mmp2 Hck Icam1 Rock1 Rhoa SIGNALING EVENTS MEDIATED BY PTP1B%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY PTP1B Signaling events mediated by PTP1B Trpv6 Fgr Lck Lat Ptpn1 Cdh2 Fyn Pdgfb Blk Csf1r Pdgfrb Itga2b Nox4 Crk Yes1 Akt1 Txn1 Csf1 Src Bcar1 Lepr Leprot Capn1 Dok1 Ins2 Ybx1 Lep Egfr Shc1 Hck Pik3r1 Stat3 Stat5a Csn2 Prl Fer Insr Lyn Grb2 Rhoa Irs1 Csk LOC103693683 Stat5b Spry2 Socs3 REGULATION OF RETINOBLASTOMA PROTEIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RETINOBLASTOMA PROTEIN Regulation of retinoblastoma protein Hdac1 Mdm2 Ccna2 Tbp Cdkn1a Suv39h1 Ckm Pax3 Aatf Ctbp1 Dnmt1 Rbp2 Brd2 Suv39h1l1 Atf7 Hdac3 Smarca4 Crebbp Atf2 Raf1 Jun Cdk4 Csf2 Mapk9 Cdk6 Mapk14 Ppp2ca Ccnd3 Gsc Pparg Cdk2 Ubtf Cbx4 Smarcb1 Cebpa Mef2c Cdkn2a LOC100909750 E2f3 E2f1 Ccnd1 Tgfb2 Ccne1 Mitf Abl1 Mapk11 Elf1 Spi1 Hdac1l Cdkn1b Skp2 Myod1 Rb1 Runx2 Bglap CERAMIDE SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CERAMIDE SIGNALING PATHWAY Ceramide signaling pathway Asah1 Prkra Bag4 Ksr1 Smpd3 Aifm1 Tnfrsf1a Smpd1 Sphk2 Bid Tradd Casp8 Akt1 Ripk1 Birc3 Fadd Mapk1 Prkcz Cradd Mapk8 Traf2 Raf1 Madd Ctsd Myc Map2k4 Nfkb1 Pdgfa Map2k2 Bad Map2k1 Rela Eif2ak2 LOC100912399 Cycs Map3k1 Nfkbia Prkcd Bax Pawr Bcl2 CLASS I PI3K SIGNALING EVENTS MEDIATED BY AKT%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CLASS I PI3K SIGNALING EVENTS MEDIATED BY AKT Class I PI3K signaling events mediated by Akt Mapkap1 Kpna1 Cdkn1a Ywhae Akt3 Akt1 Src Sfn Raf1 Rictor Prkdc Chuk Ywhaz Gsk3a Bad Foxo3 Casp9 Ywhab Pdpk1 Gsk3b Ywhag Mlst8 Ywhah Cdkn1b Akt2 Foxo4 Prkaca Bcl2l1 LOC103692716 Foxo1 Mtor Slc2a4 PLK3 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLK3 SIGNALING EVENTS PLK3 signaling events Ccne1 Chek2 Plk3 Tp53 Cdc25c VALIDATED TRANSCRIPTIONAL TARGETS OF DELTANP63 ISOFORMS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TRANSCRIPTIONAL TARGETS OF DELTANP63 ISOFORMS Validated transcriptional targets of deltaNp63 isoforms Wwp1 Mdm2 Runx1 Stxbp4 Cdkn2a Perp Gpx2 T Mre11a Itga3 Ada Notch1 Brca2 Hbp1 Sfn Igfbp3 Atm Tcf7l1 Il1a Hells Hes1 Adrm1 Col5a1 Nrg1 Ppp2r5a Sec14l2 Rab38 LOC100911660 Rrad Dlx5 Axl Gsk3b Vdr Tp63 Krt14 Bdkrb2 INTEGRIN-LINKED KINASE SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTEGRIN-LINKED KINASE SIGNALING Integrin-linked kinase signaling Parp1 Ppp1r14b Ilkap Ckap5 Ppp1r14c Ppp1r14a Tacc3 Zeb1 Diaph1 Git2 Arhgef6 Tns1 Lims2 Myl9 Parva Naca Cdc37 Elmo2 Zyx Parvb Pxn Ruvbl2 Iqgap1 Ccnd1 Akt1 Nck2 Creb1 Ilk Rac1 Xpo1 Rhog Rictor Jun Snai1 Gsk3b Ppp1r12a Aurka Arhgef7 LOC103692716 Actn1 Ruvbl1 DOWNSTREAM SIGNALING IN NAIVE CD8+ T CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DOWNSTREAM SIGNALING IN NAIVE CD8+ T CELLS Downstream signaling in naive CD8+ T cells Ptpn7 Ifnar1 LOC100912356 Tnfrsf4 Egr4 Tnfrsf9 Faslg B2m Cd8b Cd8a Prkcb Il2rg Cd3e Cd247 Cd3d Cd3g Ifng Mapk1 Mapk8 Kras Prkca Raf1 Fos Jun Egr1 Junb Map2k2 Fosl1 Map2k1 Prkcq Nras Hras Il2ra Mapk9 Elk1 Nfatc3 Stat1 Nfatc2 Il2 LISSENCEPHALY GENE (LIS1) IN NEURONAL MIGRATION AND DEVELOPMENT%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LISSENCEPHALY GENE (LIS1) IN NEURONAL MIGRATION AND DEVELOPMENT Lissencephaly gene (LIS1) in neuronal migration and development Rac1 Dynlt1 Csnk2a1 Dync1h1 Lrpap1 Cdk5 Cdk5r2 Pafah1b3 Abl1 Pla2g7 Dcx Ndel1 Katna1 Ywhae Pafah1b1 Vldlr Reln LOC100909750 Iqgap1 Rhoa Dab1 Cdk5r1 Map1b Lrp8 ERBB RECEPTOR SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB RECEPTOR SIGNALING NETWORK ErbB receptor signaling network Erbb3 Egfr Hbegf Nrg1 Tgfa Nrg4 Nrg3 Erbb2 Ereg Areg Btc Erbb4 LOC103692716 Nrg2 EPHRIN B REVERSE SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRIN B REVERSE SIGNALING Ephrin B reverse signaling Rac1 Mapk8 Src Fgr Lck Map2k4 Efnb1 Efnb2 Ephb1 Fyn Map3k7 Hck Pik3r1 Blk Itga2b Ephb2 Lyn Dnm1 Yes1 Rgs3 Nck2 Ptpn13 Tiam1 FOXA1 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXA1 TRANSCRIPTION FACTOR NETWORK FOXA1 transcription factor network Pou2f1 Tff1 Brca1 Shh Vtn Foxa1 Nfib C4bpb Pisd Nfic Gcg Sftpa1 Scgb1a1 Esr1 Sp1 Serpina1 Foxa2 Col18a1 Foxa3 Nkx3-1 Crebbp Fos Dscam Ar Ins2 Jun Ndufv3 Nr2f2 Apob Xbp1 Prdm15 Atp5j Nrip1 Cdkn1b Ap1b1 Sod1 P53 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P53 PATHWAY p53 pathway Mdm2 Stt3a Trim28 Ccna2 Csnk1g1 Ppp2r4 Csnk1g2 Chek2 Kat5 Cse1l Hipk2 Daxx Csnk1d Csnk1g3 Csnk1e Usp7 Setd7 Setd8 Crebbp Mapk8 Gsk3b Csnk1a1 Rpl11 Mapk9 Mapk14 Ppp2ca Ube2d1 Prkcd Cdk2 Prmt5 LOC364561 Cdkn2a LOC100909750 Rchy1 Akt1 Ccng1 Atr LOC100909949 Ppm1d Rpl23 Ttc5 Smyd2 Kat8 Atm Rassf1 Fbxo11 Abl1 Yy1 E4f1 Mdm4 Nedd8 Dyrk2 Pin1 Skp2 Tp53 PLASMA MEMBRANE ESTROGEN RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLASMA MEMBRANE ESTROGEN RECEPTOR SIGNALING Plasma membrane estrogen receptor signaling Gnai2 Esr1 Gnai1 Gnaz Plcb2 Akt1 Gnal Gnb1 Gnao1 Pelp1 Gnai3 Src Plcb3 Gna15 Kras Bcar1 Plcb1 Gna14 Esr2 Gna13 Gna11 Rock2 Gnaq Strn Hbegf Mmp9 Shc1 Mapk11 Mmp2 Nos3 Pik3r1 Nras Hras Igf1r Grb2 Rhoa Sos1 Msn ENDOGENOUS TLR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ENDOGENOUS TLR SIGNALING Endogenous TLR signaling Hspd1 Chuk Irak4 Sftpa1 Cd14 Tlr2 Tlr3 Myd88 Vcan Ikbkb Rhoa Irak2 Tirap Tlr4 Tlr6 S100a9 S100a8 IL8- AND CXCR2-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL8- AND CXCR2-MEDIATED SIGNALING EVENTS IL8- and CXCR2-mediated signaling events Arrb2 Pik3cg Fgr Rac2 Cxcr2 Cbl Prkcb Gnai2 Vasp Pik3r6 Plcb2 Akt1 Gnb1 Plcb3 Gna15 Gna14 Plcb1 Prkca Arrb1 Pld2 Rab7a Rab11a Hck Pdpk1 Lyn Dnm1 Ppp2ca Ppp2r1a EGF RECEPTOR (ERBB1) SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EGF RECEPTOR (ERBB1) SIGNALING PATHWAY EGF receptor (ErbB1) signaling pathway Pip5k1c Plcg1 Ptpn1 Gsn Tln1 Gnai1 Pik3cb Nck2 Mapk1 Gnai3 Src Kras Egfr Gab1 Ptk2 Shc1 Pak1 Pik3r1 Stat3 Rasa1 Ptpn6 Nras Hras Grb2 Ptpn11 Nck1 Stat1 Sos1 ATF-2 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATF-2 TRANSCRIPTION FACTOR NETWORK ATF-2 transcription factor network Dusp1 Dusp5 Brca1 Sele Ccna2 Kat5 Ddit3 Cbfb Mapk1 Mapk8 Prkca Atf2 Fos Jun Gadd45a Cdk4 Th Mapk9 Il23a Bcl2l1 Mapk14 Bcl2 Pou2f1 Ppargc1a Jund Jdp2 H2afy Plau Csrp2 Hbg1 Arg1 Esr1 Pdgfra Ruvbl2 Ccnd1 Tgfb2 LOC497963 Ifng Atf3 Cul3 Nf1 Creb1 Ins2 Serpinb5 Il6 Hes1 Dusp10 Junb Mapk11 Mmp2 Rb1 Socs3 ERBB4 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB4 SIGNALING EVENTS ErbB4 signaling events Wwp1 Mdm2 Fyn Cbfa2t3 Grin2b Pik3cb Dlg4 Mapk1 Adam17 Hbegf Nrg1 Tab2 Shc1 Pik3r1 Stat5a Nrg4 Prl Nrg3 Erbb2 Ereg Lrig1 Grb2 Btc Erbb4 Stat5b Nrg2 ANGIOPOIETIN RECEPTOR TIE2-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ANGIOPOIETIN RECEPTOR TIE2-MEDIATED SIGNALING Angiopoietin receptor Tie2-mediated signaling Cdkn1a Fes Tek Fyn Elf2 Itga5 Angpt4 Angpt2 Pxn Bmx F2 Crk Akt1 Mapk1 Rac1 Mapk8 Grb7 Dok2 Plg Agtr1a Fn1 Nfkb1 Fgf2 Ptk2 Pld2 Shc1 Rps6kb1 Pak1 Mmp2 Nos3 Elf1 Pik3r1 Stat5a Rela Rasa1 Angpt1 Elk1 Grb2 Mapk14 Ptpn11 Ets1 Itgb1 Grb14 Nck1 Foxo1 Stat5b CALCINEURIN-REGULATED NFAT-DEPENDENT TRANSCRIPTION IN LYMPHOCYTES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CALCINEURIN-REGULATED NFAT-DEPENDENT TRANSCRIPTION IN LYMPHOCYTES Calcineurin-regulated NFAT-dependent transcription in lymphocytes Pou2f1 Ptgs2 Batf3 Cd40lg Tbx21 Egr4 Faslg Ptpn1 Maf E2f1 Ifng Egr2 Casp3 Fos Gata3 Jun Dgka Slc3a2 Egr3 Egr1 Junb Fosl1 Cdk4 Il4 Csf2 Prkcq Cblb Foxp3 Il2ra Nfatc3 Nfatc2 Il5 Pparg Il2 FOXM1 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXM1 TRANSCRIPTION FACTOR NETWORK FOXM1 transcription factor network Cdk2 Ccna2 Chek2 Plk1 Tgfa Cdc25b Cdkn2a Esr1 Sp1 Lama4 Hspa1a Hspa1b Ccnd1 Cks1l Brca2 Crebbp Cenpf Ccne1 Foxm1 Etv5 Fos Onecut1 Cks1b Myc Cenpa Gsk3a Mmp2 Map2k1 Cdk4 Xrcc1 Skp2 Aurkb Rb1 Nfatc3 Cdk1 IL8- AND CXCR1-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL8- AND CXCR1-MEDIATED SIGNALING EVENTS IL8- and CXCR1-mediated signaling events Arrb2 Pik3cg Plcb3 Gna15 Fgr Gna14 Plcb1 Prkca Arrb1 Cbl Pld1 Prkcb Gnai2 Hck Pdpk1 Pik3r6 Lyn Adrbk1 Plcb2 Dnm1 Cxcr1 Akt1 Gnb1 EPHB FORWARD SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHB FORWARD SIGNALING EPHB forward signaling Rap1b Pxn Rap1a Crk Mapk1 Src Rac1 Rras Kras Grb7 Efnb1 Tf Efnb2 Ephb3 Ephb1 Ptk2 Shc1 Pak1 Kalrn Synj1 Map2k1 Pik3r1 Rasa1 Ephb2 Nras Rock1 Hras Efnb3 Grb2 Dnm1 Nck1 Itsn1 SIGNALING EVENTS MEDIATED BY STEM CELL FACTOR RECEPTOR (C-KIT)%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY STEM CELL FACTOR RECEPTOR (C-KIT) Signaling events mediated by Stem cell factor receptor (c-Kit) Kit Kitlg Crkl Cbl Grb10 Ptpro Stap1 Akt1 Spred2 LOC100911248 Pik3c2b Spred1 Crebbp Mapk8 Socs1 Pten Matk Raf1 Mitf Epo Dok1 Tec Epor Gab1 Map2k2 Shc1 Rps6kb1 Bad Foxo3 Map2k1 Pik3r1 Pdpk1 Stat3 Stat5a Gsk3b Fer Ptpn6 Hras Lyn Grb2 Ptpn11 Sh2b2 Vav1 Stat1 Sos1 Bcl2 Map4k1 SIGNALING EVENTS MEDIATED BY HDAC CLASS I%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HDAC CLASS I Signaling events mediated by HDAC Class I Gatad2b Hdac2 Hdac1 Chd3 Sirt6 Chd4 Sirt4 Sirt5 Fkbp3 Wdr77 Hdac8 Btrc Mta2 Smad7 Mbd2 Mbd3 Gata1 LOC100911453 LOC100911167 Gatad2a Smurf1 Hdac6 Hdac3 Crebbp Xpo1 Nfkb1 Hdac11 Hdac10 Gata2 Ran Rela Prkaca Ncor2 Pparg Prmt5 Tnfrsf1a Ranbp2 Nr2c1 Ube2i Hdac4 Sirt2 Sin3a Sirt3 Max Mxd1 Yy1 Smg5 Rbbp7 RGD1561590 Stat3 Hdac1l Sap18 Nfkbia ALTERNATIVE NF-KAPPAB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALTERNATIVE NF-KAPPAB PATHWAY Alternative NF-kappaB pathway Map3k14 Nfkb1 Nfkb2 Btrc Chuk A4B7 INTEGRIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%A4B7 INTEGRIN SIGNALING a4b7 Integrin signaling Itgb7 Pxn Itga4 Rhoa Vcam1 Itgb1 Ptk2 Madcam1 C-MYC PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%C-MYC PATHWAY C-MYC pathway Hbp1 Max Pml Taf9 Myc Supt7l Zbtb17 Kat5 Ppp2r5a Pak2 LOC364561 Pin1 Cdkn2a Actl6a Gsk3b Skp2 Ruvbl2 Ppp2ca Ruvbl1 Kat2a TNF RECEPTOR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TNF RECEPTOR SIGNALING PATHWAY TNF receptor signaling pathway Bag4 Cyld Birc2 Tnfrsf1a Smpd1 Tradd Casp8 Ripk1 Birc3 Map2k7 Fadd Map3k3 Prkcz Txn1 Traf2 Adam17 Madd Smpd2 Nfkb1 Map4k5 Nsmaf Tnik Rffl Tab2 Map4k3 Chuk Tnfrsf1b Map4k2 Nrk Map3k7 Rela Ikbkb Sqstm1 LOC100912399 Map3k1 Stat1 Prkci VEGF AND VEGFR SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VEGF AND VEGFR SIGNALING NETWORK VEGF and VEGFR signaling network Vegfc Figf Flt4 LOC100911280 Vegfa Nrp1 Flt1 Nrp2 Pgf ERBB2 ERBB3 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB2 ERBB3 SIGNALING EVENTS ErbB2 ErbB3 signaling events Usp8 Mapk10 Pik3cb Akt1 Chrna1 Nfatc4 Mapk1 Nf2 Src Rac1 Mapk8 Chrne Kras Rnf41 Raf1 Fos Erbb3 Jun Nrg1 Map2k2 Shc1 Ppp3cb Bad Map2k1 Pik3r1 Stat3 Erbb2 Nras Hras Mapk9 Prkaca Grb2 Ptpn11 Sos1 Nrg2 Mtor S1P5 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P5 PATHWAY S1P5 pathway Gnai2 Gnao1 Gnai3 Gnai1 Gnaz Gna12 Rhoa S1pr5 FGF SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FGF SIGNALING PATHWAY FGF signaling pathway Cbl Ssh1 Ptk2b Ctnnd1 Plcg1 Fgfr4 Fgf19 Fgfr3 Sdc2 Plau Cdh2 Spp1 Fgf23 Akt1 Mapk1 Src Fos Jun Camk2a Gab1 Fgfr1 Cdh1 Mmp9 Shc1 Rps6ka1 Pak4 Pdpk1 Pik3r1 Fgfr2 Fgf1 Il17rd Ncam1 Frs2 Grb2 Ptpn11 Cttn Runx2 Stat1 Stat5b Spry2 Sos1 Bglap BARD1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BARD1 SIGNALING EVENTS BARD1 signaling events Cdk2 Fancd2 Brca1 Rbbp8 LOC100911267 Pcna LOC100912481 Ube2d3 Topbp1 Fancl Rad51 Fanca Ewsr1 Fancf Cstf1 Fancc Bard1 Xrcc5 Fance Xrcc6 Mre11a Nbn Atr Ccne1 Atm Rad50 Prkdc Ube2l3 Tp53 SIGNALING EVENTS MEDIATED BY FOCAL ADHESION KINASE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY FOCAL ADHESION KINASE Signaling events mediated by focal adhesion kinase Vcl Itga5 Crk Yes1 Mapk1 Src Rac1 Mapk8 Bcar1 Grb7 Raf1 Jun Ptk2 Acta1 Pak1 Mapk9 Rhoa Ets1 Arhgef7 Itgb1 Actn1 Mapk8ip3 Rap1b Plcg1 Arhgap26 Tln1 Fyn Git2 Capn2 Pxn Bmx Rap1a Ccnd1 Nck2 Rras Map2k4 Rock2 Asap1 Arhgef11 Arhgef28 Arhgap35 Map2k1 Pik3r1 LOC100909609 Dock1 Rasa1 Grb2 Nck1 Sos1 HIF-2-ALPHA TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HIF-2-ALPHA TRANSCRIPTION FACTOR NETWORK HIF-2-alpha transcription factor network Tceb1 Efna1 Vhl Twist1 Egln3 Egln2 Hif1an Arnt Eif3e Apex1 Epas1 Slc11a2 Pou5f1 Sp1 Mmp14 Adora2a Serpine1 Abcg2 Pgk1 Crebbp Epo LOC100911280 Vegfa Flt1 Cited2 Bhlhe40 Elk1 Ets1 Slc2a1 GLYPICAN 1 NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN 1 NETWORK Glypican 1 network Tdgf1 Serpinc1 Fgr Lck Tgfbr1 Tgfb3 Fyn Smad2 Blk Yes1 Pla2g2a Slit2 Prnp Src Lama1 Tgfbr2 LOC100911280 Vegfa Fgf2 Flt1 Nrg1 Fgfr1 Tgfb1 Hck Lyn App ALPHA6 BETA4 INTEGRIN-LIGAND INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA6 BETA4 INTEGRIN-LIGAND INTERACTIONS Alpha6 beta4 integrin-ligand interactions Itga6 Lama1 Itgb4 Lamb1 Lamb3 Lamb2 Lamc2 Lamc1 SIGNALING MEDIATED BY P38-GAMMA AND P38-DELTA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING MEDIATED BY P38-GAMMA AND P38-DELTA Signaling mediated by p38-gamma and p38-delta Mapk13 Stmn1 Map2k6 Snta1 Ccnd1 Pkn1 Eef2k Mapk12 HEDGEHOG SIGNALING EVENTS MEDIATED BY GLI PROTEINS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HEDGEHOG SIGNALING EVENTS MEDIATED BY GLI PROTEINS Hedgehog signaling events mediated by Gli proteins Hdac2 Arrb2 Hdac1 Shh Ptch1 Csnk1g1 Csnk1g2 Gli2 Btrc Gnai2 Gnai1 Gnaz Csnk1d Csnk1g3 Smo Fbxw11 Csnk1e Akt1 Foxa2 Gnb1 Gnao1 Gnai3 Crebbp Sin3a Lgals3 Xpo1 Pias1 Mtss1 Rbbp7 Gli1 Map2k1 RGD1561590 Spop Gsk3b Hdac1l Csnk1a1 Sap18 Prkaca Stk36 Kif3a Prkcd Ift88 Rab23 Sufu UROKINASE-TYPE PLASMINOGEN ACTIVATOR (UPA) AND UPAR-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%UROKINASE-TYPE PLASMINOGEN ACTIVATOR (UPA) AND UPAR-MEDIATED SIGNALING Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling Fpr2 Elane Ctrc Klk4 Mmp12 Ctsg Fpr1 Fpr3 Vtn Mmp13 Lrp1 Gpld1 Plau Pdgfrb Vldlr Itga5 Hgf Itgb2 Itga3 Crk Itgam Serpine1 Src Rac1 Bcar1 Plg Fn1 Egfr Mmp9 Fga Tgfb1 Fgb LOC100909609 Dock1 Fgg Itgb1 REGULATION OF RAC1 ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RAC1 ACTIVITY Regulation of RAC1 activity Eps8 Arhgef6 Arhgef2 LOC100912512 Ngef Dock6 Vav3 Ralbp1 Abi1 Arhgap1 Spata13 Rac1 Arhgap17 Rap1gds1 Prex1 Arhgef25 Prex2 Arhgdia Def6 Racgap1 Arhgap9 Kalrn LOC100909609 Dock1 Abr Vav2 Trio Arhgef7 Vav1 Sos1 Tiam1 IL12 SIGNALING MEDIATED BY STAT4%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL12 SIGNALING MEDIATED BY STAT4 IL12 signaling mediated by STAT4 Pias2 Cd86 Tbx21 Il18r1 Cd28 Cd80 Cd3e Cd247 Cd3d RT1-Da RT1-Db1 Cd3g Ifng Mapk8 Crebbp Etv5 Fos Jun Il13 Cd4 Tgfb1 Stat3 Irf1 Mapk9 Il2ra Stat1 Il18 Il2 HIV-1 NEF: NEGATIVE EFFECTOR OF FAS AND TNF-ALPHA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HIV-1 NEF: NEGATIVE EFFECTOR OF FAS AND TNF-ALPHA HIV-1 Nef: Negative effector of Fas and TNF-alpha Bag4 Faslg Tnfrsf1a Apaf1 Cflar Bid Tradd Casp8 Cd247 Daxx Map3k14 Ripk1 Fas Birc3 Map2k7 Fadd Cradd Mapk8 Traf2 Casp3 Nfkb1 Chuk Casp2 Casp6 Casp9 Rela Cycs Nfkbia Bcl2 GABA-B_RECEPTOR_II_SIGNALING%PANTHER PATHWAY%P05731 GABA-B_receptor_II_signaling Gng8 Gabbr1 Prkacb Adcy8 Cacna1a Cacna1b Gabbr2 Gng3 Gng7 Gngt2 Gng5 Cacna1g Gnao1 Prkar1b Gnb2 Gnb1 Gng11 Gnai3 Kcnj3 Gnb4 Gnb3 Adcy4 Prkar2b Prkar2a Gnai1 Adcy7 Prkaca Adcy6 Adcy5 DNA REPLICATION%PANTHER PATHWAY%P00017 DNA replication Rfc4 Rfc1 Pold1 Rfc2 Pold2 Pcna Rnaseh1 H3f3b Rpa2 Rfc5 Top1 Rfc3 PRPP BIOSYNTHESIS%PANTHER PATHWAY%P02760 PRPP biosynthesis NICOTINE PHARMACODYNAMICS PATHWAY%PANTHER PATHWAY%P06587 Nicotine pharmacodynamics pathway Clic6 Drd4 Drd2 Flna Chrna3 Chrna4 Chrna6 Cacna1g Kcnk9 Gnb1 Epb41l2 Chrna5 Ppp1ca Th Ppp1r1b Kcnk3 Cacna1c Chrnb2 Chrnb3 Slc18a2 Gnai1 Epb4.1 Prkaca Chrnb4 Ddc CYTOSKELETAL REGULATION BY RHO GTPASE%PANTHER PATHWAY%P00016 Cytoskeletal regulation by Rho GTPase Myh9 Actbl2 Arpc1b Arpc4 Arpc5 Rhoc Rock2 Tubb2a Enah Rac2 Myh1 Myh3 Arpc3 Arpc2 Myh7 Myh6 Pak1 Actg2 Vasp LOC100361457 Arhgap1 Arhgap8 Rac1 Acta1 Pak7 Pak6 Pak2 LOC100909840 Pak4 Pak3 Actg1 Mylk Myo3a Actc1 Tubb2b Rock1 LOC100911597 Mylk3 Myh14 Pfn3 Pfn2 Pfn1 Myh11 Tubb5 Cfl2 Cfl1 Tubb4a Limk1 Actb Stmn1 Mylk2 Myh10 Tubb3 Tubb6 Ssh1 Myh7b Diaph1 Stmn4 VITAMIN B6 BIOSYNTHESIS%PANTHER PATHWAY%P02786 Vitamin B6 biosynthesis HISTAMINE SYNTHESIS%PANTHER PATHWAY%P04387 Histamine synthesis Hdc ALLANTOIN DEGRADATION%PANTHER PATHWAY%P02725 Allantoin degradation Allc HETEROTRIMERIC G-PROTEIN SIGNALING PATHWAY-GI ALPHA AND GS ALPHA MEDIATED PATHWAY%PANTHER PATHWAY%P00026 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway Oprd1 Phka1 Pygl Creb3l4 Creb3l3 Creb3l2 Pygb Phkb Oprl1 Pygm Drd4 Drd2 Gng8 Htr2b Htr2c Prkacb Adcy8 Drd1 Htr2a Drd5 Oprk1 Gng3 Htr6 Gng7 Htr7 Gngt2 Adrbk1 Gng5 Htr4 Gnrhr LOC100911796 Chrm4 Chrm5 Prkar1b Htr1a Gnb2 Cltc Gnb1 Htr1b Chrm2 Chrm1 Gnai3 Gys2 Kcnj3 Chrm3 Gys1 Cltb Adcy4 Htr1d Prkar2b Clta Prkar2a Htr1f Gnai1 Gngt1 Adcy7 Mtnr1a Mtnr1b Prkaca Adcy6 Kcnj5 Adcy5 Kcnj9 Adra1a Phkg1 Grk6 Adra1d Grk5 Grk4 Kcnj6 Grk1 Adrb1 Gsk3b Gnal Adra2c Rap1a Rap1b Adrb3 Phkg2 Gpsm1 Gpsm2 Gng12 Adora2a Adora2b Gsk3a Adra2b Adrb2 Rgs18 Rgs10 Rgs12 Htr5a Grm1 Grm2 Grm8 Grm6 Rgs19 Hrh4 Rgs2 Rgs14 Hrh1 Rgs17 Gpr50 Rgs1 Rgs5 Rgs7 Rgs8 Rgs9 Rgs3 Hrh2 Rgs4 Rgs16 Gng10 Sstr2 Creb1 Sstr1 Sstr5 Creb5 Sstr3 Sstr4 Adcy3 Gnai2 Adora1 Creb3l1 Oprm1 Creb3 Adora3 Crebbp AMINOBUTYRATE DEGRADATION%PANTHER PATHWAY%P02726 Aminobutyrate degradation Abat MRNA SPLICING%PANTHER PATHWAY%P00058 mRNA splicing Prpf3 Zrsr2 Snrpb2 Snrpa SCW_SIGNALING_PATHWAY%PANTHER PATHWAY%P06216 SCW_signaling_pathway CIRCADIAN CLOCK SYSTEM%PANTHER PATHWAY%P00015 Circadian clock system Per3 Clock LOC100911602 Arntl Csnk1e Csnk1d Per2 Cry1 Per1 Cry2 P53 PATHWAY FEEDBACK LOOPS 2%PANTHER PATHWAY%P04398 p53 pathway feedback loops 2 Ccna1 Atr Mapk11 Ccna2 Pik3c2a Pik3c2b Siah1 Atm Kras Ccne1 Rbl1 Pik3r2 Pten Cdkn1a Pik3r3 Pdpk1 Pik3r1 Myc Hras Tp63 Pik3r5 Ccng1 Mapk14 Pik3c2g Mapk13 Mapk12 Akt2 Pik3cb Ppp2cb Ppp2ca Pik3cd Akt3 Tp53 Rb1 Tp73 Pik3cg Nras Cdk2 Pik3c3 Akt1 5HT1 TYPE RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04373 5HT1 type receptor mediated signaling pathway Gng12 Gng8 Prkacb Vamp3 Gng3 Gng7 Gngt2 Gng5 Gnao1 Htr1a Gng10 Gnb2 Kcnk9 Gnb1 Htr1b Gng11 Gnai3 Gnb4 Kcnk3 Gnb3 Htr1d Snap29 Prkar2b Gnai2 Vamp1 Htr1f Slc6a4 Prkar2a Vamp2 Gnai1 Adcy7 Gnb5 Prkaca Prkx Stx3 COENZYME A BIOSYNTHESIS%PANTHER PATHWAY%P02736 Coenzyme A biosynthesis LOC100362038 Dcakd Pank1 Pank4 Pank3 5HT4 TYPE RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04376 5HT4 type receptor mediated signaling pathway Gnal Gng12 Gng8 Vamp3 Gng3 Slc18a1 Gng7 Vamp8 Gngt2 Htr4 Gng5 Gng10 Kcnk9 Gnb2 Gnb1 Gnb4 Kcnk3 Gnb3 Snap29 Vamp1 Slc6a4 Slc18a2 Vamp2 Adcy7 Gnb5 Stx3 ANGIOGENESIS%PANTHER PATHWAY%P00005 Angiogenesis Prkcd Casp9 Prkch Prkcb Pdgfrb Rhoc Prkci F3 Pdgfra Dvl1 Prkca Wnt7b F7 Notch1 Wnt7a Notch2 Crk Pak1 Notch4 Prkcq Pla2g4cl1 Dvl3 Arhgap1 Tek Arhgap8 Pld2 Pld1 LOC686302 Araf Map3k1 Pak2 Sphk1 Prkd3 Sphk2 Pak3 Wnt5a Wnt5b Src Prkd1 Prkd2 Stat3 Sh2d2a Ephb2 Stat1 Fgf1 Wnt1 Rbpjl Nos3 Fzd5 Prr5 Fzd2 Crkl Ephb3 Ephb1 Cryab Tgfb1i1 Map2k1 F2r Pdgfa Efnb2 Pik3c2a Jag1 Pik3c2b Fzd1 Map2k4 Map2k2 Rasa1 Tcf7 Wnt10b Hif1a Pdgfb Efnb1 Pxn LOC100911248 Shc2 Pik3r2 Lpxn Jun Plcg1 Pik3r3 Sos1 Pdgfc Pik3r1 LOC100912399 Wnt10a Hras Nck1 Wnt2b Dll3 Mapkapk3 Mapk14 Mapk1 Mapkapk2 Dll4 Shc1 Angpt2 Akt2 Pik3cb Jak1 Nck2 Sfrp1 Mapk8 Dok1 Pik3cd Dok3 Dok2 Akt3 Hspb1 Grb7 Prkcz Pik3cg Dlk1 Nras Angpt1 Grb14 Pik3c3 Fgfr1 Grap Akt1 Pla2g4d Apc2 Epha3 Frzb Fos Raf1 Ptk2 Ets1 Rhoa Rhob Pla2g4a Apc Frs3 Frs2 Pla2g4c Vegfa Gsk3b LEUCINE BIOSYNTHESIS%PANTHER PATHWAY%P02749 Leucine biosynthesis Bcat2 Bcat1 INTEGRIN SIGNALLING PATHWAY%PANTHER PATHWAY%P00034 Integrin signalling pathway Itga11 Actbl2 Arf6 Arpc1b Col8a2 Flnb Arpc5 Elmo2 Rhoc Dock1 Itga10 Col3a1 Col1a2 Rac2 Col1a1 Ptpn12 Rap2b Arpc3 Arl1 Arpc2 Ilk Mapk6 Mapk9 Crk Col4a2 Col4a3 Vasp Asap1 LOC100361457 Arhgap10 Col5a1 Col5a2 Rac1 Col5a3 Col4a1 Araf Col9a2 Col9a1 Col4a5 LOC100909609 Col8a1 Dnajc27 Actg1 Col6a1 Src Col6a2 Lama4 Lama1 Col17a1 Map3k4 Itga3 Itga4 Map3k2 Map3k3 Parva Ptk2b Parvb Col16a1 Itga8 Itga7 Itga6 Itga5 Itga2b Col20a1 LOC100911572 Lims2 Itgbl1 Vcl Col13a1 Csk Actn2 Actn1 Bcar1 Col11a2 Fn1 Col11a1 Col14a1 Actn4 Crkl Map2k1 Pik3c2a Pik3c2b Map2k4 Map2k2 Pxn LOC100911248 Mapk10 Lamb1 Pik3r2 Rras Itgax Itgb8 Pik3r3 Sos1 Itgam Itgal Pik3r1 Col27a1 Hras Tln1 Rnd2 Rnd3 Fyn Arfgap1 Lamb3 Mapk13 Rnd1 Shc1 Lamb2 Pik3cb Mapk8 Pik3cd Lamc1 Arhgap26 Itgb7 Pik3cg Itgb6 Itgb2 Nras Itgb1 Lamc2 Pik3c3 Itgb4 Flna Raf1 Ptk2 Rhoa Rhob Rap1a Rap1b Actb CORTOCOTROPIN RELEASING FACTOR RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04380 Cortocotropin releasing factor receptor signaling pathway Pomc Crhr1 Gnal Gnaq Crh Gna14 Gna11 Gng12 Gng8 Vamp3 Gng3 Gng7 Vamp8 Gngt2 Gng5 Gng10 Gnb2 Gnb1 Crhr2 Gnb4 Gnb3 Snap29 Vamp1 Vamp2 Gnb5 Stx3 GENERAL TRANSCRIPTION BY RNA POLYMERASE I%PANTHER PATHWAY%P00022 General transcription by RNA polymerase I Ubtf Polr1b LOC100910121 Ptrf Taf8 RGD1562299 Ttf1 Taf1c Tbp Tbpl2 Psmc3ip Tbpl1 Rrn3 TGF-BETA SIGNALING PATHWAY%PANTHER PATHWAY%P00052 TGF-beta signaling pathway Bmp3 Bmp4 Bmp1 Bmp2 Bmp6 Tgfbr1 Map3k7 Atf2 Nodal Jund Tgfbr2 Bmp7 Tgfb2 Bmpr2 Acvr1b Mapk9 Lefty1 Tgfb3 Smad5 Fkbp1a Smad6 Smad1 Smad2 Smad7 Junb Zfyve9 Acvrl1 Bambi Smad3 Acvr2b Acvr2a Fosl1 Smurf1 Bmp8a Gdnf Dcp1b Fkbp2 Lefty2 Skil Bmp15 Foxh1 Snip1 Gdf11 Gdf10 Gdf9 Gdf15 Zfyve16 Amhr2 Gdf6 Acvr1 Inhbb Gdf7 Gdf2 Inhba Gdf3 Inhbc Acvr1c Inhbe Mstn Tll2 Cited2 Cited1 Mapk11 Mapk10 Jun Rras Hras Mapk1 Mapk14 Mapk13 Mapk12 Mapk8 Nras Crebbp UBIQUITIN PROTEASOME PATHWAY%PANTHER PATHWAY%P00060 Ubiquitin proteasome pathway Uba3 Ube2a LOC103694902 Uba2 Psmd4 Ube2t Smurf1 Ube2d1 Psmd2 Mdm2 Ube2n Psmd7 Ube2s Ube2k Psmd1 Ube2l6 Ube2l3 Ube2e3 Uba1 Ube2c Atg7 Ube2g2 Ube2g1 Wwp1 Uba7 Uba6 Psmc4 Psmd14 Psmd13 Ube2d3 Ube2v2 Ube3a Sae1 Trex2 Ube2d4 SYNAPTIC_VESICLE_TRAFFICKING%PANTHER PATHWAY%P05734 Synaptic_vesicle_trafficking Stxbp1 Syt5 Stx1a Syt1 Rab3a Syt15 Unc13b Nsf Unc13d Stx1b Syt6 Vamp1 Stx2 Syt7 Syt2 Syt12 Syt11 Syt3 ASCORBATE DEGRADATION%PANTHER PATHWAY%P02729 Ascorbate degradation Rpe PHENYLETHYLAMINE DEGRADATION%PANTHER PATHWAY%P02766 Phenylethylamine degradation Aoc1 Aoc3 VASOPRESSIN SYNTHESIS%PANTHER PATHWAY%P04395 Vasopressin synthesis Spcs3 Sec11a Pam Avp Prep Sec11c Spcs2 Nhlrc3 Prepl Oxt MUSCARINIC ACETYLCHOLINE RECEPTOR 1 AND 3 SIGNALING PATHWAY%PANTHER PATHWAY%P00042 Muscarinic acetylcholine receptor 1 and 3 signaling pathway Prkcd Prkch Prkcb Prkci Prkca Gnaq Gna14 Gna11 Prkcq Slc5a7 Grin1 Gng8 Grin2b Grin2c Vamp3 Gng3 Gng7 Pkn1 Gngt2 Pkn2 Vamp8 Gng5 Itpr3 Itpr1 Plcb4 Chat Bche Grin2d Gng10 Gnb2 Stx1a Gnb1 Gng11 Chrm1 Chrm3 Gnb4 Gnb3 Stx1b Snap29 Vamp1 Prkcz Vamp2 Gnb5 METHYLCITRATE CYCLE%PANTHER PATHWAY%P02754 Methylcitrate cycle Aco1 Ireb2 TRIACYLGLYCEROL METABOLISM%PANTHER PATHWAY%P02782 Triacylglycerol metabolism Lipe SALVAGE PYRIMIDINE DEOXYRIBONUCLEOTIDES%PANTHER PATHWAY%P02774 Salvage pyrimidine deoxyribonucleotides Cda LOC100909857 ANANDAMIDE_DEGRADATION%PANTHER PATHWAY%P05728 Anandamide_degradation Faah PENTOSE PHOSPHATE PATHWAY%PANTHER PATHWAY%P02762 Pentose phosphate pathway Gpi Tkt Taldo1 Rpia Hk2 GLYCOLYSIS%PANTHER PATHWAY%P00024 Glycolysis Eno1 Bpgm Pgk1 Gpi Pfkl Pgam2 LOC100911625 Pklr Aldoa Hk2 Eno2 Pkm ADRENALINE AND NORADRENALINE BIOSYNTHESIS%PANTHER PATHWAY%P00001 Adrenaline and noradrenaline biosynthesis Stx12 Slc18a1 Maob Slc6a20 Slc6a15 Th Slc6a16 Maoa Stx7 Snap29 Nnmt Vamp1 Slc6a18 Dbh Slc18a2 Vamp2 Slc6a19 Slc6a2 Comt Inmt Ddc Slc6a3 PLASMINOGEN ACTIVATING CASCADE%PANTHER PATHWAY%P00050 Plasminogen activating cascade Cpb2 Mmp1 Serpinb2 Plat Mmp13 Plg Mmp9 Serpinf2 Serpine1 Fga Fgb Fgg Plau O-ANTIGEN BIOSYNTHESIS%PANTHER PATHWAY%P02757 O-antigen biosynthesis Tgds Gfpt2 Gfpt1 HEME BIOSYNTHESIS%PANTHER PATHWAY%P02746 Heme biosynthesis Alad Urod Hmbs Ppox Qars Ears2 Fech Eprs Cpox ANDROGEN ESTROGENE PROGESTERONE BIOSYNTHESIS%PANTHER PATHWAY%P02727 Androgen estrogene progesterone biosynthesis Lipa Hsd17b2 Cyp19a1 Hsd17b1 Soat2 LOC100362350 Soat1 Hsd17b3 Hsd17b6 Hsd17b7 HUNTINGTON DISEASE%PANTHER PATHWAY%P00029 Huntington disease Actbl2 Arf6 Arpc1b Arpc5 Tubb2a Rac2 Arl1 Mapk9 Actg2 LOC100361457 Rac1 Acta1 Actg1 Actc1 Tubb2b Map2k4 Tbp Jun Tp63 Akt2 Akt3 Tp53 Tp73 Akt1 Fos Cltb Apaf1 Rhoj Rhoq Rhog LOC100912380 Cyfip1 Dlg4 Ap2a1 Ap2a2 Kalrn Dync2h1 Capns1 Dync1i1 Hap1 Optn Map3k10 Arf4 Dynll1 Dynll2 Actr2 Dync1i2 Sp1 Arl4a Cyc1 Map2k7 Dctn1 Arl4d Dync1li1 Dync1li2 Dync1h1 Arf5 Dnai2 Gapdhs Hip1r Arfip2 Grik1 Dnah5 Grik4 Grin1 Grik5 Grin2b Grik2 Grin2c Grik3 LOC100911363 Casp3 Pacsin1 Sh3gl3 Tubb5 Bdnf Ift57 Tubb4a Casp8 Htt Actb Capn12 Capn11 Hip1 Tnfaip8 Grin2d Synj1 Capn3 Capn2 Dnal4 Capn5 Capn7 Capn6 Capn1 Tubb3 Tubb6 Capn9 Crebbp ARGININE BIOSYNTHESIS%PANTHER PATHWAY%P02728 Arginine biosynthesis Cad Ass1 Nags Cps1 Otc Asl NOTCH SIGNALING PATHWAY%PANTHER PATHWAY%P00045 Notch signaling pathway Rbpjl Maml1 Fut8 Mfng Dll3 Lnx2 Notch1 Dll4 Notch2 Adam17 Notch4 Neurl4 Pofut1 Neurl2 Notch3 Jag1 Cir1 Lfng Lnx1 Ncor2 Dlk1 Neurl1 Psen1 Ncstn SUCCINATE TO PROPRIONATE CONVERSION%PANTHER PATHWAY%P02777 Succinate to proprionate conversion Pccb Echdc1 BUPROPION_DEGRADATION%PANTHER PATHWAY%P05729 Bupropion_degradation Cyp2b2 PYRUVATE METABOLISM%PANTHER PATHWAY%P02772 Pyruvate metabolism Me1 Pc Pdha2 Cs Acly Pklr Pck1 Clybl Pkm DE NOVO PYRIMIDINE DEOXYRIBONUCLEOTIDE BIOSYNTHESIS%PANTHER PATHWAY%P02739 De novo pyrimidine deoxyribonucleotide biosynthesis Decr2 Nme3 Tyms Rrm2b Nme1 Dtymk Dscaml1 Rrm2 AXON GUIDANCE MEDIATED BY SLIT ROBO%PANTHER PATHWAY%P00008 Axon guidance mediated by Slit Robo Slit1 Dcc Slit2 Slit3 LOC100909750 Rhoc Ntng1 Abl1 Ntn3 Rac2 Cxcr4 Rac1 Ntn1 Robo1 Srgap1 Cxcl12 P53 PATHWAY%PANTHER PATHWAY%P00059 p53 pathway Atr Atm Ccne1 Traf2 Pml Cdkn2a Pten Mta2 Cdkn1a Sin3a Mdm2 Gadd45b Pdpk1 Gadd45a Gadd45g Cdk1 Tp63 Hdac1l Sumo3 Mdm4 Chek2 Akt2 Ppp2cb Ppp2ca Akt3 Tp53 Tp73 Hdac1 Cdk2 Sfn Gtse1 Akt1 Crebbp Cdc25c 5HT2 TYPE RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04374 5HT2 type receptor mediated signaling pathway Prkcd Prkch Prkcb Prkci Prkca Gnaq Gna14 Gna11 Prkcq Gng12 Plcb3 Plce1 Plcz1 Plcd4 Plcd1 Plcl1 Plcb1 Plcb2 Gng8 Htr2b Htr2c Plcg1 Htr2a Gng3 Gng7 Slc18a1 Gngt2 Gng5 Plcb4 Gng10 Gnb2 Kcnk9 Gnb1 Gng11 Gnb4 Kcnk3 Gnb3 Slc6a4 Slc18a2 Prkcz Gnb5 T CELL ACTIVATION%PANTHER PATHWAY%P00053 T cell activation Mapk9 Pak1 Prkcq Rac1 Araf Map3k1 Pak2 Pak3 Fos Raf1 Csk Map2k1 Map2k2 Vav2 Vav1 Pik3r2 Jun Cd28 Lat Plcg1 Pik3r3 Sos1 Cd80 Vav3 Pik3r1 Nfkbia LOC100912399 Cd86 Hras Nck1 Itpr1 Mapk1 Akt2 Pik3cb Nck2 Cd3g Mapk8 Cd3e Cd3d Pik3cd Akt3 Chuk Ppp3cb Ppp3ca Lck Ikbkb Pik3cg Lcp2 Nras Cd247 Ptprc Pik3c3 Zap70 Akt1 PROLINE BIOSYNTHESIS%PANTHER PATHWAY%P02768 Proline biosynthesis MUSCARINIC ACETYLCHOLINE RECEPTOR 2 AND 4 SIGNALING PATHWAY%PANTHER PATHWAY%P00043 Muscarinic acetylcholine receptor 2 and 4 signaling pathway Kcnj6 Gnat2 Stx4 Stx16 Gnat1 Slc5a7 Gng8 Prkacb Vamp3 Gng3 Gng7 Gngt2 Vamp8 Gng5 Chat Chrm4 Gnao1 Bche Prkar1b Gng10 Gnb2 Stx1a Gnb1 Chrm2 Gng11 Gnai3 Kcnj3 Gnb4 Gnb3 Stx1b Snap29 Vamp1 Gnai2 Prkar2b Prkar2a Vamp2 Gnai1 Gnb5 Prkaca Kcnj5 Prkx Kcnj9 FORMYLTETRAHYDROFORMATE BIOSYNTHESIS%PANTHER PATHWAY%P02743 Formyltetrahydroformate biosynthesis Dhfr Mtr Tyms Mthfd2 Mthfd1l GLUTAMINE GLUTAMATE CONVERSION%PANTHER PATHWAY%P02745 Glutamine glutamate conversion Lgsn METABOTROPIC GLUTAMATE RECEPTOR GROUP I PATHWAY%PANTHER PATHWAY%P00041 Metabotropic glutamate receptor group I pathway Grin1 Grin2b Grik5 Prkacb Grin2c Prkcb Gnaq Itpr1 Plcb4 Gna11 Grin2d Prkar1b Gna15 Grm1 Prkaca Grik1 Grina Prkx METHIONINE BIOSYNTHESIS%PANTHER PATHWAY%P02753 Methionine biosynthesis Mtr ADENINE AND HYPOXANTHINE SALVAGE PATHWAY%PANTHER PATHWAY%P02723 Adenine and hypoxanthine salvage pathway Ada Xdh Aprt Prtfdc1 Pnp ANGIOTENSIN_II-STIMULATED_SIGNALING_THROUGH_G_PROTEINS_AND_BETA-ARRESTIN%PANTHER PATHWAY%P05911 Angiotensin_II-stimulated_signaling_through_G_proteins_and_beta-arrestin Grk6 Grk5 Prkca Gnaq Map2k1 Plcb3 Map2k2 Plcb1 Plcb2 Gng8 Arrb2 Agt Elk1 Arrb1 Raf1 Gng3 Gng7 Adrbk1 Gngt2 Itpr3 Itpr1 Egr1 Mapk1 Agtr1a Gng10 Gnb2 Gnb1 Gng11 Gnb4 Gnb3 Gnb5 5-HYDROXYTRYPTAMINE DEGREDATION%PANTHER PATHWAY%P04372 5-Hydroxytryptamine degredation Aldh3a1 Aldh7a1 Aldh1l2 Aldh1a3 Maob Aldh16a1 Aldh2 Aldh1a1 Aldh1b1 Aldh3a2 Aldh8a1 Maoa Aldh9a1 P53 PATHWAY BY GLUCOSE DEPRIVATION%PANTHER PATHWAY%P04397 p53 pathway by glucose deprivation Prkab2 Tp63 Akt2 Igbp1 Ppp2cb Ppp2ca Akt3 Rps6kb1 Tp53 Prkab1 Tsc1 Tp73 Eif4ebp1 Prkaa1 Tsc2 Stk11 Akt1 Prkaa2 ALZHEIMER DISEASE-AMYLOID SECRETASE PATHWAY%PANTHER PATHWAY%P00003 Alzheimer disease-amyloid secretase pathway Prkcd Prkch Prkcb Prkci Prkca Mapk6 Adam17 Mapk9 Prkcq Psen1 Ncstn Chrm4 Chrm5 Chrm2 Chrm1 Chrm3 Cacna1c Pcsk7 Kat5 App Pcsk4 Klc1 Cacnb2 Bace2 Bace1 Apba3 Apba1 Mapk15 Apba2 Pcsk2 Pcsk6 Aph1b Pcsk1 Mapk4 Cacna1f Furin Mapk11 Chrna7 Psenen Cacna1d Adam9 Mapk10 Pkn1 Pkn2 Mapk1 Mapk14 Mapk13 Mapk12 Mapk8 Klc2 Cacnb1 Klc4 Prkcz Klc3 Psen2 LOC100911293 GENERAL TRANSCRIPTION REGULATION%PANTHER PATHWAY%P00023 General transcription regulation Taf6 Gtf2h4 Gtf2f2 Gtf2f1 Taf7 Gtf2h1 Taf8 RGD1562299 Ttf1 Taf1c Tbpl1 Polr2f Polr2h Gtf2a1l Taf9 Taf11 Gtf2b Gtf2e2 LOC100912534 Polr2c Gtf2a1 Brf2 RGD1565904 Gtf2e1 Brf1 Gtf2h3 Mterfd3 Taf9b Taf2 VALINE BIOSYNTHESIS%PANTHER PATHWAY%P02785 Valine biosynthesis Bcat2 Bcat1 Ilvbl GBB_SIGNALING_PATHWAY%PANTHER PATHWAY%P06214 GBB_signaling_pathway DPP-SCW_SIGNALING_PATHWAY%PANTHER PATHWAY%P06212 DPP-SCW_signaling_pathway GASTRIN_CCK2R_240212%PANTHER PATHWAY%P06959 Gastrin_CCK2R_240212 Prkcd Prkch Prkcb Prkca Mapk9 Crk Pak1 Traf6 Arhgef28 Prkcq Elk4 Srf Rps6ka3 Klf4 Rac1 Rps6 Rps6ka1 LOC100911372 Araf Csnk1a1 Akt1s1 Snai1 Irs1 Ap2m1 Gast Hbegf Src Prkd1 Prkd2 Ptk2b Csnk1e Csnk1d Csk Bcar1 Rock1 Foxo1 Stat3 Mef2b Mef2c Tpst1 Lyn Yes1 Cckbr Bax Foxo3 Map2k1 Map2k4 Map2k2 Pxn Mapk10 Odc1 Ptpn11 Pten Jun Cdh1 Plcg1 Nr2c2 Gucy2d Sos1 Pdpk1 Pparg Pik3r1 Grb2 Ywhab Bcl2l1 Nfatc2 Clu Map2k6 Mapk14 Mapk1 Cd38 Cck Bcl2 Shc1 Elavl1 Map3k14 Pik3cb Nos1 Dnm1 Pde1a Mapk8 Map2k5 Tcf4 Map3k11 Ptgs2 Akap1 Hspb1 Camkk1 Bad Men1 Mef2d Itgb1 Ier3 Camk4 Akt1 Cnksr1 Atf2 Rps6kb1 Eif4ebp1 Plau Arrb2 Prkacb Elk1 Fos Raf1 Ptk2 Rhoa Pla2g4a Egr1 Gnb1 Slc18a2 Prkaca Gsk3b Sp1 Rgs2 Casp3 Nfkbia Itpr1 Creb1 Ppp3ca PYRIDOXAL PHOSPHATE SALVAGE PATHWAY%PANTHER PATHWAY%P02770 Pyridoxal phosphate salvage pathway HETEROTRIMERIC G-PROTEIN SIGNALING PATHWAY-GQ ALPHA AND GO ALPHA MEDIATED PATHWAY%PANTHER PATHWAY%P00027 Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway Prkcd Oprd1 Prkch Prkcb Prkci Prkca Oprl1 Prkcq Plcb3 Dnajc27 Plcb1 Plcb2 Gnaq Gna14 Gna11 Bdkrb1 Cacna1e Rap1gap Bdkrb2 Rasgrp2 Rasgrp1 Rasgrp4 Rasgrp3 Gng13 Gpr45 Prkcz Drd4 Drd2 Gng8 Drd1 Cacna1a Drd5 Cacna1b Oprk1 Gng3 Rhoa Gng7 Adrbk1 Gngt2 Gng5 Gnrhr LOC100911796 Chrm4 Gnao1 Chrm5 Gnb2 Cltc Gnb1 Chrm2 Chrm1 Chrm3 Kcnj3 Gnb4 Gnb3 Cltb Clta Gngt1 Kcnj5 Kcnj9 Grk6 Grk5 Grk4 Kcnj6 Rap1a Rap1b Gpsm1 Gpsm2 Gng12 Adora2a Adora2b Rgs18 Gna15 Rgs10 Rgs12 Grm1 Grm2 Grm8 Grm6 Rgs19 Rgs2 Rgs14 Rgs17 Rgs1 Rgs5 Rgs7 Itpr3 Rgs8 Itpr1 Rgs9 Plcb4 Rgs3 Rgs4 Rgs16 Gng10 Sstr2 Sstr1 Sstr5 Sstr3 Sstr4 Adora1 Oprm1 Adora3 IONOTROPIC GLUTAMATE RECEPTOR PATHWAY%PANTHER PATHWAY%P00037 Ionotropic glutamate receptor pathway Slc1a6 Slc1a7 Slc1a1 Pick1 Slc1a3 Gria3 Gria4 Grm2 Grik1 Grik4 Grin1 Grik5 Grin2b Grin2c Grik2 Grik3 Vamp3 Vamp8 Grin2d Camk2a Camk2d Shank3 Shank1 Slc17a8 Slc17a6 Nsf Cacng2 Cacng5 Snap29 Vamp1 Vamp2 MANNOSE METABOLISM%PANTHER PATHWAY%P02752 Mannose metabolism Gmppa Gmds Gmppb Pmm2 Pmm1 Mpi INSULIN IGF PATHWAY-PROTEIN KINASE B SIGNALING CASCADE%PANTHER PATHWAY%P00033 Insulin IGF pathway-protein kinase B signaling cascade Foxo1 Pten Mdm2 Pdpk1 Insr Gsk3b Mdm4 Igf1r Ins2 Igf2 Foxo3 Igf1 Igf2r Irs2 Gsk3a Tsc1 Irs1 Tsc2 JAK STAT SIGNALING PATHWAY%PANTHER PATHWAY%P00038 JAK STAT signaling pathway Stat3 Stat6 Pias3 Pias2 Stat1 Mapk14 Jak1 Socs1 Stat5a Pias1 Ptprc Jak3 Stat5b MYO_SIGNALING_PATHWAY%PANTHER PATHWAY%P06215 MYO_signaling_pathway TRYPTOPHAN BIOSYNTHESIS%PANTHER PATHWAY%P02783 Tryptophan biosynthesis XANTHINE AND GUANINE SALVAGE PATHWAY%PANTHER PATHWAY%P02788 Xanthine and guanine salvage pathway Prtfdc1 Pnp Gda ORNITHINE DEGRADATION%PANTHER PATHWAY%P02758 Ornithine degradation Odc1 Azin1 FRUCTOSE GALACTOSE METABOLISM%PANTHER PATHWAY%P02744 Fructose galactose metabolism Khk Gale Aldoc Aldoa Hk2 Galt Aldob P38 MAPK PATHWAY%PANTHER PATHWAY%P05918 p38 MAPK pathway Mknk2 Mef2b Mknk1 Mef2c Map3k7 Map3k10 Traf6 Mapk11 Srf Map2k4 Tab2 Rps6ka5 Dusp10 Atf1 Il1r1 Dusp1 Eef2k Elk1 Map3k4 Gadd45a Map2k6 Mapkapk3 Mapk14 Mapkapk2 Mapk13 Mapk12 Hspb1 Mef2d HISTIDINE BIOSYNTHESIS%PANTHER PATHWAY%P02747 Histidine biosynthesis LYSINE BIOSYNTHESIS%PANTHER PATHWAY%P02751 Lysine biosynthesis WNT SIGNALING PATHWAY%PANTHER PATHWAY%P00057 Wnt signaling pathway Prkcd Prkch Prkcb Prkci Dvl1 Prkca Wnt7b Wnt7a Prkcq Dvl3 Plcb3 Wnt5a Wnt5b Plcb1 Plcb2 Hdac1l Hdac1 Wnt1 Fzd5 Fzd2 Fzd1 Wnt10b Wnt10a Wnt2b Sfrp1 Prkcz Wnt4 Cdh16 Cdh17 Arid1a Cdh15 Ep400 Tgfbr1 Cdh10 Map3k7 Cdh13 Ppp2r5b Pcdh18 Ppp2r5c Ppp2r5a Cdh19 Pcdh12 Wnt3 Acvr1b Wnt11 LOC100909468 Smad5 Cdh9 Lef1 Pcdh20 Csnk2b Smad1 Wnt16 Aes Pcdh19 Hdac3 Hdac2 Cdh2 Cdh3 Hdac8 Cdh5 Cdh6 Cdh7 Ankrd6 Sfrp2 Pcdhac1 Pcdhac2 Csnk2a2 Sfrp5 Btrc Sfrp4 Pcdh7 Pcdh8 Cdh24 Fat2 Wnt3a Tbl1xr1 Ino80 Pcdh9 Pcdha11 Pcdha12 Tcf7l1 Pcdha13 Cdh20 Fat1 Pcdha10 Fat3 Acvr1c Ppp3r1 Tbl1x Siah2 Ppp3r2 Tle3 Chd1l Tle1 Tle4 Pcdhb10 Fzd6 Hltf Kremen2 Fzd9 Nfatc4 Fzd4 Pcdhb19 Pcdhb20 Nkd2 Nfatc3 Nkd1 Celsr1 Celsr2 Pcdhb22 Pcdhb21 Pygo2 Smarcd1 Smarcd3 Smarcd2 Pcdha6 Pcdha9 Pcdha8 Pygo1 Wnt9a Ctnna1 Wnt9b Pcdha7 Lrp6 Smarcc1 Smarcal1 Lrp5 Smarcc2 Cdhr1 Pcdhb3 Cdhr2 Ctnnal1 Pcdhb5 Pcdhb1 Pcdhb2 Wnt8b Wnt8a Smarcb1 Csnk1g3 Nlk Csnk1g2 Arr3 Smarca5 Smarca2 Smarca1 Sag Smarca4 Ppp2r5e Dact1 Smarce1 Hells Fstl1 LOC100911660 Cdh11 Wnt6 Ctbp2 Tle2 Fbxw11 Ctbp1 Csnk1a1 Csnk1e Csnk1d Gnaq Gna14 Gna11 Siah1 Gng13 Cdh1 Nfatc2 Ppp2cb Ppp2ca Arrb2 Gng8 Arrb1 Frzb Gng3 Gng7 Gng5 Gnb2 Gnb1 Gnb4 Gnb3 Gsk3b Gng12 Gna15 Itpr3 Itpr1 Plcb4 Gng10 Ppp3cb Ppp3ca Crebbp DE NOVO PURINE BIOSYNTHESIS%PANTHER PATHWAY%P02738 De novo purine biosynthesis Decr2 Nme3 Rrm2b Nme7 Nme1 Dscaml1 Rrm2 Ak2 Ppat Ak4 Gart Ak3 Gmps Atic Impdh2 Nme6 Guk1 Adsl Ak8 Adss ATP SYNTHESIS%PANTHER PATHWAY%P02721 ATP synthesis Atp5c1 Taf3 Atp5b PNAT%PANTHER PATHWAY%P05912 PNAT Clic6 Drd4 Drd2 Flna Gng8 Prkacb Drd1 Vamp3 Drd5 Gng3 Epb41l3 Vamp8 Ppp1cc Maob Gnb2 Kcnk9 Epb41l2 Gnb1 Gng11 Ppp1ca Th Gnai3 Ppp1r1b Maoa Kcnk3 Gnb4 Gnaz Gnb3 Snap29 Vamp1 Gnai2 Prkar2b Dbh Slc18a2 Prkar2a Epb4.1 Vamp2 Gnai1 Adcy7 Comt Prkaca Prkx Ddc Slc6a3 Stx3 PYRIMIDINE METABOLISM%PANTHER PATHWAY%P02771 Pyrimidine Metabolism Dpysl3 Abat Dpysl2 Dpys Dpysl5 Nt5e Cda Aldh6a1 LOC100910964 LOC100909857 Upb1 LOC103692570 CADHERIN SIGNALING PATHWAY%PANTHER PATHWAY%P00012 Cadherin signaling pathway Actbl2 Wnt7b Wnt7a Actg2 LOC100361457 Acta1 Wnt5a Wnt5b Actg1 Src Actc1 Lyn Yes1 Wnt1 Fzd5 Fzd2 Egfr Ptpn1 Ctnnd1 Fer Ctnnd2 Frk Erbb4 Erbb3 Erbb2 Fzd1 Wnt10b Cdh1 Wnt10a Wnt2b Fyn Wnt4 Cdh16 Cdh17 Cdh15 Cdh10 Cdh13 Pcdh18 Cdh19 Pcdh12 Wnt3 Wnt11 Cdh9 Lef1 Pcdh20 Csnk2b Wnt16 Pcdh19 Cdh2 Cdh3 Cdh5 Cdh6 Cdh7 Pcdhac1 Pcdhac2 Csnk2a2 Pcdh7 Pcdh8 Cdh24 Fat2 Wnt3a Pcdh9 Pcdha11 Pcdha12 Tcf7l1 Pcdha13 Cdh20 Fat1 Pcdha10 Fat3 Pcdhb10 Fzd6 Fzd9 Gsk3b Fzd4 Pcdhb19 Pcdhb20 Actr2 Celsr1 Celsr2 Pcdhb22 Pcdhb21 Pcdha6 Pcdha9 Pcdha8 Wnt9a Wnt9b Pcdha7 Cdhr1 Pcdhb3 Cdhr2 Pcdhb5 Pcdhb1 Pcdhb2 Actb Wnt8b Wnt8a Fstl1 Cdh11 Wnt6 APOPTOSIS SIGNALING PATHWAY%PANTHER PATHWAY%P00006 Apoptosis signaling pathway Gzmf Prkcd Atf6 Casp9 Atf4 Prkch Atf3 Prkcb Tradd Eif2s1 Map4k2 Atf2 Prkca Mapk9 Cradd Prkcq Cflar Bag4 LOC100910060 Igf2r Map4k3 Rela Bik Madd Bcl2l11 Bcl2l2 Map3k1 Bcl2l10 Ripk1 Atf7 Fadd Faslg Endog Nfkb1 Traf2 Nfkb2 Aifm1 Bok Fos Birc2 Birc3 Jdp2 Cycs Tnfrsf1a Tnfsf10 Atf6b Tnfrsf1b Lta Bag3 Bak1 Prkra Diablo Eif2ak2 Apaf1 Daxx Hspa5 Hspa1b Hspa1a Xiap Hspa2 Fas Bax Map2k7 Map2k4 Atf1 Mapk10 Jun Casp3 Nfkbia LOC100912399 Bcl2l1 Casp8 Mapk1 Bcl2 Akt2 Map3k14 Pik3cb Mapk8 Pik3cd Akt3 Chuk Tp53 Pik3cg Ikbkb Akt1 INTERFERON-GAMMA SIGNALING PATHWAY%PANTHER PATHWAY%P00035 Interferon-gamma signaling pathway Cish Mapk10 Ptpn6 Ifng Pias3 Socs3 Stat1 Pias2 Mapk15 Pias4 Mapk1 Ifngr2 Mapk14 Ifngr1 Mapk13 Socs6 Mapk12 Socs5 Mapk9 Jak1 Mapk11 Mapk8 Pias1 RAS PATHWAY%PANTHER PATHWAY%P04393 Ras Pathway Rhoc Atf2 Rac2 Mapk9 Pak1 Srf Rps6ka3 Pld2 Pld1 Rac1 Rps6ka1 Araf Map3k1 Pak2 Pak3 Elk1 Map3k4 Raf1 Ets1 Rhoa Rhob Stat3 Stat1 Gsk3b Map2k1 Ralb Rala Mapk11 Rgl1 Map2k7 Exoc2 Ralgds Gsk3a Rgl2 Map2k4 Map2k2 Kras Tiam1 Rps6ka6 Rps6ka2 Mapk10 Jun Sos1 Pdpk1 Grb2 LOC100912399 Hras Map2k6 Mapkapk3 Mapk14 Mapk1 Mapkapk2 Mapk13 Shc1 Mapk12 Pik3cb Mapk8 Pik3cd Akt3 Pik3cg Nras Pik3c3 Akt1 CHORISMATE BIOSYNTHESIS%PANTHER PATHWAY%P02734 Chorismate biosynthesis P53 PATHWAY FEEDBACK LOOPS 1%PANTHER PATHWAY%P04392 P53 pathway feedback loops 1 Mdm2 Tp53 Tp63 Tp73 Mdm4 OXYTOCIN RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04391 Oxytocin receptor mediated signaling pathway Prkcd Prkch Prkcb Prkci Prkca Gnaq Gna14 Gna11 Prkcq Gng12 Plcb3 Plce1 Oxtr Plcz1 Plcd4 Plcd1 Plcl1 Plcb1 Plcb2 Gng8 Plcg1 Vamp3 Gng3 Gng7 Gngt2 Vamp8 Gng5 Plcb4 Gng10 Gnb2 Gnb1 Gnb4 Gnb3 Snap29 Vamp1 Prkcz Vamp2 Gnb5 Stx3 ACETATE UTILIZATION%PANTHER PATHWAY%P02722 Acetate utilization Acss3 Acss2 Acss1 OXIDATIVE STRESS RESPONSE%PANTHER PATHWAY%P00046 Oxidative stress response Mknk2 Mknk1 Mef2c Stat1 Mapk9 Dusp18 Dusp9 Dusp6 Mapk11 Dusp19 Dusp7 Dusp4 Map2k4 Dusp5 Dusp2 Dusp10 Txn1 Dusp12 Dusp16 Dusp1 Dusp15 Eef2k Jun Elk1 Myc Pla2g4a Map2k6 Mapk14 Bcl2 Mapk13 Mapk12 Dusp26 Dusp27 Mapk8 Dusp3 Ddit3 Max Dupd1 ALZHEIMER DISEASE-PRESENILIN PATHWAY%PANTHER PATHWAY%P00004 Alzheimer disease-presenilin pathway Wnt4 Actbl2 Dvl1 Wnt7b Notch1 Wnt7a Wnt3 Notch2 Wnt11 Adam17 Notch4 Actg2 Lef1 LOC100361457 Notch3 Dvl3 Mmp1 Wnt16 Mmp13 Acta1 Mmp9 Cdh3 Psen1 Wnt5a Actg1 Wnt5b Ncstn Mmp20 Mmp21 Mmp27 Lrp1 Kat7 Trim3 Apbb2 Pvrl1 Lrp3 Lrp2 Mmp2 Cd44 Mmp23 Wnt3a Mmp8 Mmp7 Lrp4 Tcf7l1 Actc1 Apbb3 Pcsk7 Kat5 App Pcsk4 Wnt1 Fzd6 Rbpjl Bace2 Bace1 Fzd9 Fzd5 Gsk3b Fzd2 Fzd4 Pcsk2 Pcsk6 Actr2 Aph1b Pcsk1 Mmp17 Mmp15 Furin Mmp16 Erbb4 Trpc4 Trpc5 Trpc6 Psenen Fzd1 Mmp14 Trpc7 Mmp19 Ern1 Wnt10b Jup Wnt9a Wnt9b Lrp6 Cdh1 Lrp5 Wnt10a Wnt2b Actb Wnt8b Wnt8a Fstl1 Psen2 LOC100911293 Wnt6 BETA3 ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04379 Beta3 adrenergic receptor signaling pathway Gng8 Vamp3 Gng3 Gng7 Gngt2 Vamp8 Gnal Gng5 Adrb3 Gng10 Gnb2 Gnb1 Gng12 Gnb4 Gnb3 Snap29 Vamp1 Vamp2 Adcy7 Gnb5 Stx3 PANTOTHENATE BIOSYNTHESIS%PANTHER PATHWAY%P02761 Pantothenate biosynthesis ALANINE BIOSYNTHESIS%PANTHER PATHWAY%P02724 Alanine biosynthesis Bcat2 Bcat1 OPIOID PROOPIOMELANOCORTIN PATHWAY%PANTHER PATHWAY%P05917 Opioid proopiomelanocortin pathway Oprd1 Pomc Gng12 Gng8 Vamp3 Gng3 Gng7 Vamp8 Gngt2 Gng5 Gnao1 Gnb2 Gng10 Gnb1 Gnai3 Gnb4 Gnb3 Snap29 Gnai2 Vamp1 Gnai1 Vamp2 Adcy7 Gnb5 Stx3 TOLL RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00054 Toll receptor signaling pathway Map3k7 Mapk9 Traf6 Map2k1 Map2k2 Map3k8 Irf3 Jun Tbk1 Elk1 Tirap Ecsit Ticam2 Ube2n LOC100362142 Nfkbia Mapk14 Ikbke Nfkbie Cd14 Tlr3 Mapk8 Tlr2 Tlr4 Chuk Myd88 Tlr7 Tlr6 Irak3 Ikbkb LOC100912618 Irak4 Ube2v1 Tank Tollip VITAMIN B6 METABOLISM%PANTHER PATHWAY%P02787 Vitamin B6 metabolism Psat1 HETEROTRIMERIC G-PROTEIN SIGNALING PATHWAY-ROD OUTER SEGMENT PHOTOTRANSDUCTION%PANTHER PATHWAY%P00028 Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction Grk1 Gnat1 Cnga1 Gng12 Pde6b Rcvrn Calml3 Pde6a Cngb3 Pdc Rho Cngb1 Gng13 Gng8 Prkacb Gng3 Gng7 Gngt2 Gng5 Rgs9 Gng10 Gnb2 Gnb1 Gnb4 Gngt1 Prkaca Gnb5 UNTITLED%PANTHER PATHWAY%P06664 untitled Rela Skil Tgif1 HEDGEHOG SIGNALING PATHWAY%PANTHER PATHWAY%P00025 Hedgehog signaling pathway Smo Stk36 Sufu Btrc Gli1 Fbxw11 Ptch1 Ubr5 Shh Gsk3b Csnk1e Prkar1b Prkar2b Csnk1a1 Prkar2a Crebbp BETA2 ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04378 Beta2 adrenergic receptor signaling pathway Gng8 Prkacb Gng3 Gng7 Gngt2 Gnal Gng5 Gng10 Gnb2 Gnb1 Gng12 Gnb4 Gnb3 Adrb2 Prkar2b Prkar2a Adcy7 Prkaca Gnb5 Prkx PURINE METABOLISM%PANTHER PATHWAY%P02769 Purine metabolism Xdh Ampd3 Nt5e Gda BMP_SIGNALING_PATHWAY-DROSOPHILA%PANTHER PATHWAY%P06211 BMP_signaling_pathway-drosophila OPIOID PROENKEPHALIN PATHWAY%PANTHER PATHWAY%P05915 Opioid proenkephalin pathway Oprd1 Gng12 Gng8 Vamp3 Gng3 Gng7 Vamp8 Gngt2 Gng5 Gnb2 Gng10 Penk Gnb1 Pdyn Gnai3 Gnb4 Gnb3 Snap29 Gnai2 Vamp1 Gnai1 Vamp2 Adcy7 Gnb5 Stx3 SALVAGE PYRIMIDINE RIBONUCLEOTIDES%PANTHER PATHWAY%P02775 Salvage pyrimidine ribonucleotides Decr2 Nme3 Upp2 Uprt Uckl1 Uck1 Uck2 Upp1 ALP23B_SIGNALING_PATHWAY%PANTHER PATHWAY%P06209 ALP23B_signaling_pathway METABOTROPIC GLUTAMATE RECEPTOR GROUP II PATHWAY%PANTHER PATHWAY%P00040 Metabotropic glutamate receptor group II pathway Gnat2 Cacna1e Grm2 Gng8 Prkacb Cacna1a Vamp3 Cacna1b Gng3 Gng7 Gngt2 Vamp8 Gng5 Gnao1 Prkar1b Gng10 Gnb2 Stx1a Gnb1 Gng11 Gnai3 Gnb4 Gnb3 Stx1b Snap29 Gnai2 Cacnb1 Prkar2b Vamp1 Prkar2a Vamp2 Gnai1 Gnb5 Prkaca Prkx LIPOATE_BIOSYNTHESIS%PANTHER PATHWAY%P02750 Lipoate_biosynthesis Lias CELL CYCLE%PANTHER PATHWAY%P00013 Cell cycle Psmd4 Psmd12 Psmd11 Cinp G6pc Ccnd3 Psmd3 Psmd7 Ccne2 Psmd14 Ccne1 Psmd13 Rpa3 UNTITLED%PANTHER PATHWAY%P00019 untitled Prkcd Prkch Prkcb Prkci Prkca Prkcq Plcb3 Araf Plcb1 Plcb2 Prkacb Adcy8 Raf1 Sec11a Sec11c Pla2g4a Prkar1b Adcy4 Prkar2b Prkar2a Adcy7 Prkaca Adcy6 Adcy5 Ece1 Gucy1a3 Gucy1a2 Edn1 Gucy1b3 Prkg2 Nos3 Ece2 Ecel1 Gnal Gnaq Gna14 Edn2 Ednra Gna11 Ednrb Edn3 Pcsk1 Map2k1 Furin Map2k2 Itpr3 Itpr1 Plcb4 Mapk1 Akt2 Akt3 Ptgs2 Adcy3 Prkcz Akt1 TYROSINE BIOSYNTHESIS%PANTHER PATHWAY%P02784 Tyrosine biosynthesis VITAMIN D METABOLISM AND PATHWAY%PANTHER PATHWAY%P04396 Vitamin D metabolism and pathway Rara Vdr Cyp27a1 Rxra Gc F13b FGF SIGNALING PATHWAY%PANTHER PATHWAY%P00021 FGF signaling pathway Prkcd Prkch Prkcb Prkci Ppp2r5b Rac2 Prkca Ppp2r5c Ppp2r5a Mapk9 LOC100909468 Prkcq Rac1 Araf Map3k4 Raf1 Map3k2 Map3k3 Frs3 Frs2 Sfn Spry2 Ppp2r2a Ptpn6 Ywhag Fgfr3 Ppp2r1a Fgf1 Ppp2r1b Spry4 Spry1 Ywhaz Fgf7 Fgf6 Fgf5 Fgfr4 Fgfr2 Fgf9 Fgf8 Map2k1 Mapk11 Map2k7 Pik3c2a Pik3c2b Map2k4 Map2k2 Rasa1 Shc3 Ywhae Mapk10 Plcg1 Sos1 Ywhab Hras Map2k6 Mapk1 Mapk14 Mapk13 Shc1 Mapk12 Akt2 Fgf10 Pik3cb Fgf11 Fgf17 Fgf14 Ppp2cb Mapk8 Map3k6 Ppp2ca Pebp1 Pik3cd Fgf4 Akt3 Fgf3 Ppp2r5e Prkcz Fgf20 Pik3cg Fgf22 Nras Rasa2 Ppp2r2d Fgfr1 Fgf12 Pik3c3 Akt1 Grap Fgf13 TOLL_PATHWAY_DROSOPHILA%PANTHER PATHWAY%P06217 Toll_pathway_drosophila HISTAMINE H1 RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04385 Histamine H1 receptor mediated signaling pathway Prkcd Prkch Prkcb Prkci Prkca Gnaq Gna14 Gna11 Prkcq Gng12 Plcb3 Plce1 Plcz1 Plcd4 Plcd1 Plcl1 Plcb1 Plcb2 Gng8 Plcg1 Hrh1 Gng3 Gng7 Gngt2 Itpr3 Gng5 Itpr1 Plcb4 Gng10 Gnb2 Gnb1 Gnb4 Gnb3 Prkcz Gnb5 METHYLMALONYL PATHWAY%PANTHER PATHWAY%P02755 Methylmalonyl pathway Pccb Mcee 5-ARACHIDONYLGLYCEROL_BIOSYNTHESIS%PANTHER PATHWAY%P05726 5-arachidonylglycerol_biosynthesis Lpl Plcb3 Dagla Plcb1 Plcb2 CHOLESTEROL BIOSYNTHESIS%PANTHER PATHWAY%P00014 Cholesterol biosynthesis Fdft1 RGD1564347 Hmgcs1 Sqle Ggps1 Hmgcr Fdps LOC100360417 Mvd Pmvk NICOTINIC ACETYLCHOLINE RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00044 Nicotinic acetylcholine receptor signaling pathway Myh9 Actbl2 Myo6 Myo7b Myo7a Chrna9 Chrna1 Chrna2 Myo18b Myo1b Myh1 Myo1c Myh3 Myo1d Myo1a Chrnb1 Chrna3 Myh7 Myo1f Chrna4 Myh6 Actr1a Chrna6 Actg2 LOC100361457 Acta1 Actg1 Vamp3 Vamp8 Slc44a3 Chrna10 Stx1a Myo9a Chrna5 Plekhh3 Myo5c Chrne Myo10 Chrnd Myo3a Chrnb2 Snap29 Stx1b Actc1 Vamp1 Myo16 Chrnb3 Myo19 Vamp2 Myo5b Chrnb4 Stx4 Stx16 Slc5a7 Chrna7 LOC100911597 Myh14 Myh11 Actb Chat Bche Myh10 Myh7b THIAMIN BIOSYNTHESIS%PANTHER PATHWAY%P02779 Thiamin biosynthesis N-ACETYLGLUCOSAMINE METABOLISM%PANTHER PATHWAY%P02756 N-acetylglucosamine metabolism Gfpt2 Npl Gnpda2 Amdhd2 Gfpt1 GAMMA-AMINOBUTYRIC ACID SYNTHESIS%PANTHER PATHWAY%P04384 Gamma-aminobutyric acid synthesis Abat Gad1 Aldh5a1 Csad Gad2 BETA1 ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04377 Beta1 adrenergic receptor signaling pathway Adrb1 Gnal Gng12 Gng8 Prkacb Vamp3 Gng3 Gng7 Vamp8 Gngt2 Gng5 Gng10 Gnb2 Gnb1 Gnb4 Gnb3 Snap29 Prkar2b Vamp1 Prkar2a Vamp2 Adcy7 Prkaca Gnb5 Prkx Stx3 SULFATE ASSIMILATION%PANTHER PATHWAY%P02778 Sulfate assimilation ENDOGENOUS_CANNABINOID_SIGNALING%PANTHER PATHWAY%P05730 Endogenous_cannabinoid_signaling Gng8 Cacna1a Cacna1b Gng3 Gng7 Gngt2 Gng5 Cacna1g Gnao1 Gnb2 Gnb1 Gng11 Gnai3 Plcb3 Cnr1 Gnb4 Gnb3 Gnai1 Grm1 Plcb1 Plcb2 ACTIVINBETASIGNALING_PATHWAY%PANTHER PATHWAY%P06210 Activinbetasignaling_pathway BIOTIN BIOSYNTHESIS%PANTHER PATHWAY%P02731 Biotin biosynthesis SERINE GLYCINE BIOSYNTHESIS%PANTHER PATHWAY%P02776 Serine glycine biosynthesis Psph Psat1 Phgdh ALPHA ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00002 Alpha adrenergic receptor signaling pathway Prkcd Adra1a Vamp3 Prkca Itpr1 Adra2c Plcb4 Gna11 Plcb3 Plce1 Adra2b Vamp1 Stx6 Vamp2 Plcb1 Plcb2 ISOLEUCINE BIOSYNTHESIS%PANTHER PATHWAY%P02748 Isoleucine biosynthesis Bcat2 Bcat1 Ilvbl INFLAMMATION MEDIATED BY CHEMOKINE AND CYTOKINE SIGNALING PATHWAY%PANTHER PATHWAY%P00031 Inflammation mediated by chemokine and cytokine signaling pathway Myh9 Actbl2 Arpc1b Arpc4 Prkcb Arpc5 Rhoc Rac2 Myh1 Myh3 Arpc3 Arpc2 Myh7 Myh6 Pak1 Actg2 LOC100361457 Plcb3 Plce1 Rac1 Acta1 Plcz1 Pak7 Araf Pak6 Plcd4 Pak2 Plcd1 Plcl1 Pak4 Pak3 Actg1 Plcb1 Col6a1 Mylk Plcb2 Col6a2 Ptk2b Col20a1 Myo3a Actc1 Rock1 Col14a1 Stat3 Gnaq Gna14 Gna11 Cxcr4 Kras Rras Pten Jun Plcg1 Sos1 Pdpk1 Itgal Nfatc2 Mapk1 Shc1 Akt2 Pik3cb Pik3cd Akt3 Ptgs2 Itgb7 Prkcz Pik3cg Nras Itgb1 Grap Akt1 Ccr5 Ccr4 Ccr6 Cxcr3 Ccr7 Cxcl10 Ccr8 Cxcr2 Ltb4r2 Jund Cxcr5 Ifnar1 Ccl20 Ccl22 Ccr3 Ccl21 Rela Junb Gng8 Nfkb2 Prkacb Ccrl2 Raf1 Gng3 Rhoa Gng7 Pf4 Cx3cl1 Pla2g4a Gng5 Cx3cr1 Alox5ap Vwf Ccr1 Gnao1 Fpr1 Fpr2 Camk2a Ccl7 Camk2d Ccl4 Alox12 Ptgs1 Gnai3 Ccl2 Ccl3 Ccl5 Gnb3 Nfat5 Xcr1 Prex1 Cxcr1 Rhog Ccr9 Gnai1 Ccl12 Alox15 Prkaca Adcy6 Ccr10 Prkx Adcy5 Ccl11 Grk6 Ifng Nfatc4 Socs6 Nfatc3 Socs5 Gng12 Gna15 LOC100911597 Vav1 Mylk3 Myh14 Myh11 Itpr3 Itpr1 Plcb4 Actb Mylk2 Rgs4 Myh10 Gng10 Chuk Gnai2 Ikbkb Myh7b PYRIDOXAL-5-PHOSPHATE BIOSYNTHESIS%PANTHER PATHWAY%P02759 Pyridoxal-5-phosphate biosynthesis Psat1 PEPTIDOGLYCAN BIOSYNTHESIS%PANTHER PATHWAY%P02763 Peptidoglycan biosynthesis INSULIN IGF PATHWAY-MITOGEN ACTIVATED PROTEIN KINASE KINASE MAP KINASE CASCADE%PANTHER PATHWAY%P00032 Insulin IGF pathway-mitogen activated protein kinase kinase MAP kinase cascade Elk1 Fos Sos1 Raf1 Insr Mapk1 Igf1r Ins2 Igf2 Igf1 Map2k1 Igf2r Rps6ka3 Irs2 Map2k2 Rps6ka1 Rps6kb1 Rasa1 Rps6ka5 Irs1 Rps6ka6 Rps6ka2 PDGF SIGNALING PATHWAY%PANTHER PATHWAY%P00047 PDGF signaling pathway Pdgfrb Pdgfra Prkca Mapk6 Elk4 Srf Arhgap10 Rps6ka3 Arhgap1 Arhgap8 Rps6ka1 Araf Map3k4 Map3k2 Stat3 Stat1 Mapk15 Map2k1 Rab11b Spdef Pdgfa Fli1 Arhgap9 Arhgap5 Arhgap42 Rps6kc1 Rerg Map2k2 Rasa1 Elf5 LOC100911256 Shc3 Elf3 Srgap1 Elf4 Pdgfb Elf1 Elf2 Srgap3 Stat2 Shc2 Etv3 Mapk10 Pik3r2 Ninl Pdgfrl Jun Ophn1 Plcg1 Pik3r3 Sos1 Nin Pdpk1 Ikbkap Pik3r1 Grb2 Arhgap15 Myc Arhgap12 Nck1 Hras Erf Pik3r5 Mapk1 Gab2 Mapkapk2 Ehf Erg Shc1 Gab1 Akt2 Pik3cb Jak1 Nck2 Mapk8 Pik3cd Arhgap26 Pik3cg Nras Rasa2 Pik3c3 Grap Rps6kb1 Elk1 Fos Raf1 Ets1 Mknk2 Mknk1 Gsk3b Gsk3a Rps6ka5 Rps6ka6 Rps6ka2 Vav2 Vav1 Stat6 Vav3 Pkn2 Itpr3 Itpr1 Chuk Ikbkb Stat5a Jak3 Stat5b TETRAHYDROFOLATE BIOSYNTHESIS%PANTHER PATHWAY%P02742 Tetrahydrofolate biosynthesis Dhfr Tyms Gch1 DE NOVO PYRIMIDINE RIBONUCLEOTIDES BIOSYTHESIS%PANTHER PATHWAY%P02740 De novo pyrimidine ribonucleotides biosythesis Decr2 Nme3 Cad Cps1 Nme1 Dhodh Ctps2 Dscaml1 Ctps1 5HT3 TYPE RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04375 5HT3 type receptor mediated signaling pathway Kcnk9 Vamp3 Kcnk3 Snap29 Slc18a1 Vamp1 Vamp8 Slc6a4 Slc18a2 Vamp2 Stx3 HYPOXIA RESPONSE VIA HIF ACTIVATION%PANTHER PATHWAY%P00030 Hypoxia response via HIF activation Pten Rorc Mtor Txn2 Vhl Akt2 Arnt Egln3 Egln2 Akt3 Hif1a Txn1 Crebbp Akt1 FLAVIN BIOSYNTHESIS%PANTHER PATHWAY%P02741 Flavin biosynthesis THYROTROPIN-RELEASING HORMONE RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04394 Thyrotropin-releasing hormone receptor signaling pathway Prkcd Prkch Prkcb Prkci Cacnb2 Cacnb4 Trh Prkca Gnaq Gna14 Gna11 Cacna1e Prkcq Gng12 Plcb3 Plce1 Plcz1 Plcd4 Plcd1 Plcl1 Plcb1 Plcb2 Gng8 Plcg1 Cacna1a Vamp3 Cacna1b Gng3 Gng7 Gngt2 Vamp8 Gng5 Plcb4 Gng10 Gnb2 Gnb1 Gnb4 Gnb3 Snap29 Vamp1 Cacnb1 Prkcz Vamp2 Tshb Gnb5 Trhr Cga Stx3 UNTITLED%PANTHER PATHWAY%P05916 untitled Oxt Gng12 Gng8 Vamp3 Oprk1 Gng3 Gng7 Avp Vamp8 Gngt2 Gng5 Gnao1 Gng10 Gnb2 Gnb1 Pdyn Gnai3 Gnb4 Gnb3 Snap29 Gnai2 Vamp1 Gnai1 Vamp2 Adcy7 Gnb5 Stx3 THIAMINE METABOLISM%PANTHER PATHWAY%P02780 Thiamine metabolism Thtpa Tpk1 VEGF SIGNALING PATHWAY%PANTHER PATHWAY%P00056 VEGF signaling pathway Prkcd Casp9 Prkch Prkcb Prkci Prkca Rac2 Prkcq Arhgap1 Arhgap8 Rac1 Araf Sphk1 Prkd3 Sphk2 Prkd1 Prkd2 Raf1 Ptk2 Ets1 Pla2g4a Vegfa Sh2d2a Nos3 Prr5 Cryab Tgfb1i1 Map2k1 Pik3c2a Pik3c2b Map2k2 Hif1a Pxn Shc2 Lpxn Pik3r2 Plcg1 Pik3r3 Pik3r1 Hras Mapkapk3 Mapk14 Mapk1 Mapkapk2 Pik3cb Pik3cd Hspb1 Prkcz Pik3cg Nras Pik3c3 Akt1 TRANSCRIPTION REGULATION BY BZIP TRANSCRIPTION FACTOR%PANTHER PATHWAY%P00055 Transcription regulation by bZIP transcription factor Taf6 Gtf2h4 Gtf2f2 Gtf2f1 Taf7 Gtf2h1 Creb3l4 Creb3l3 Creb3l2 Taf8 RGD1562299 Ttf1 Taf1c Tbp Tbpl2 Psmc3ip Tbpl1 Polr2e Polr2f Polr2h Prkar1b Gtf2a1l Taf9 Taf11 Gtf2b Gtf2e2 Creb5 LOC100912534 Polr2c Gtf2a1 Brf2 RGD1565904 Prkar2b Gtf2e1 Prkar2a Brf1 Creb3l1 Gtf2h3 Mterfd3 Taf9b Taf2 Crebbp ENKEPHALIN RELEASE%PANTHER PATHWAY%P05913 Enkephalin release Oprd1 Gnal Gng12 Gng8 Prkacb Gng3 Gng7 Gngt2 Gng5 Gnao1 Gng10 Gnb2 Penk Gnb1 Creb1 Pdyn Gnai3 Gnb4 Gnb3 Gnai2 Prkar2b Prkar2a Gnai1 Oprm1 Adcy7 Gnb5 Prkaca Prkx AXON GUIDANCE MEDIATED BY SEMAPHORINS%PANTHER PATHWAY%P00007 Axon guidance mediated by semaphorins Dpysl2 Rhoa Rac2 Fyn Dpysl4 Sema3a Pak1 Frk Sema4d Fes Cdk5 Crmp1 Rac1 Plxnb1 Nrp1 Dpys Dpysl5 LOC100910964 LOC103692570 PI3 KINASE PATHWAY%PANTHER PATHWAY%P00048 PI3 kinase pathway Foxo1 Casp9 Nos3 Ywhaz Gnat2 Gsk3b Gnaq Gna14 Gna11 Foxo3 Rps6kb1 Irs1 Foxo4 Inpp5a Pik3r2 Pten Ptger1 Sos1 Pik3r3 Pdpk1 Pik3r1 Insr Gngt2 Pik3r5 Akt2 Gnb2 Pik3cb Gnb1 Gnai3 Gnb4 Akt3 Gnb3 Gnai2 Gnai1 Gngt1 Nras Gnb5 Akt1 DPP_SIGNALING_PATHWAY%PANTHER PATHWAY%P06213 DPP_signaling_pathway B CELL ACTIVATION%PANTHER PATHWAY%P00010 B cell activation Prkcd Ptpn6 Prkcb Lyn Rac2 Mapk9 Map2k1 Mapk11 Rac1 Map2k2 Araf Vav2 Mapk10 Vav1 Jun Blnk Cd22 Sos1 Fos Vav3 Raf1 Grb2 Map3k2 Nfkbia Map3k3 Hras Itpr3 Itpr1 Mapk1 Mapk14 Mapk13 Mapk12 Pik3cb Mapk8 Pik3cd Chuk Ppp3cb Ppp3ca Nfkbil1 Pik3cg Ikbkb Nras Syk Cd79b Ptprc Cd19 Cd79al NICOTINE_DEGRADATION%PANTHER PATHWAY%P05914 Nicotine_degradation Ugt1a3 Ugt1a6 Ugt2a1 Ugt1a2 Ugt1a5 Ugt1a7c Cyp2a3 Ugt1a1 Fmo3 Ugt1a8 Ugt1a9 Inmt ASPARAGINE AND ASPARTATE BIOSYNTHESIS%PANTHER PATHWAY%P02730 Asparagine and aspartate biosynthesis Asns PARKINSON DISEASE%PANTHER PATHWAY%P00049 Parkinson disease Fbxw11 Mapk9 Csnk2b Pld2 Csnk1a1 Src Elk1 Stx12 Csnk2a2 Psma7 Gpr37 Ndufv2 Ccne2 Adrbk1 Csnk1e Csnk1d Psma2 Snca Sncb Psma1 Th Psma3 Psma4 Psma5 Stx7 Psma6 Csk Psmb3 Hspa9 Hspa5 Psmb7 Hspa1b Psmb1 Hspa1a Ube2j2 Sfn Ywhah Hspa2 Gpr37l1 Slc6a3 Gp1bb Ywhag Lyn Psmb10 Yes1 Blk Cul1 Uchl1 Tor1a Ywhaz Sncaip Sept2 Mapk15 Sept1 Fgr Sept5 Hck Tor2a Frk Ccne1 Ywhae Mapk10 Ywhab Ube2l6 Ube2l3 Fyn Mapk1 Mapk14 Csnk1g3 Mapk12 Csnk1g2 Mapk8 Lck CYSTEINE BIOSYNTHESIS%PANTHER PATHWAY%P02737 Cysteine biosynthesis Cbs METABOTROPIC GLUTAMATE RECEPTOR GROUP III PATHWAY%PANTHER PATHWAY%P00039 Metabotropic glutamate receptor group III pathway Slc1a6 Slc1a7 Slc1a1 Slc1a3 Gria3 Gria4 Gng8 Prkacb Cacna1a Cacna1b Vamp3 Gng3 Gng7 Gngt2 Vamp8 Gng5 Slc17a7 Prkar1b Gnb2 Stx1a Gnb1 Gnai3 Gnb4 Gnb3 Snap29 Stx1b Prkar2b Vamp1 Prkar2a Gnai1 Vamp2 Gnb5 Prkaca Prkx Cacna1e Grm1 Grm8 Grik1 Grm6 Grik4 Grin1 Grik5 Grin2b Grin2c Grik2 Grik3 Grin2d Gng10 Gnai2 Cacnb1 PHENYLALANINE BIOSYNTHESIS%PANTHER PATHWAY%P02765 Phenylalanine biosynthesis HISTAMINE H2 RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04386 Histamine H2 receptor mediated signaling pathway Gng8 Prkacb Gng3 Gng7 Gngt2 Gnal Gng5 Hrh2 Gng10 Gnb2 Gnb1 Gng12 Gnb4 Gnb3 Prkar2b Prkar2a Adcy7 Prkaca Gnb5 Prkx AXON GUIDANCE MEDIATED BY NETRIN%PANTHER PATHWAY%P00009 Axon guidance mediated by netrin Dcc Pik3r2 Plcg1 Pik3r3 Ntng1 Pik3r1 Ntn3 Unc5d Nfatc4 Unc5c Nfatc2 Rac2 Unc5b Pik3r5 Nfatc3 Pik3cb Vasp Pik3c2a Pik3c2b Pik3cd Rac1 Ntn1 Pik3cg S-ADENOSYLMETHIONINE BIOSYNTHESIS%PANTHER PATHWAY%P02773 S-adenosylmethionine biosynthesis Mat1a Mtr Mat2a LOC100363915 FAS SIGNALING PATHWAY%PANTHER PATHWAY%P00020 FAS signaling pathway Lmnb1 Gsn Casp9 Dffb Lmnb2 Scin Casp6 Parp2 Parp1 Capg Lmna Faf1 Mapk9 Parp3 Cflar Cyc1 Map2k4 Fadd Faslg Mapk10 Jun Casp3 Casp8 Mapk8 Apaf1 Daxx Fas TCA CYCLE%PANTHER PATHWAY%P00051 TCA cycle Ogdh Mdh1 Pdha2 Cs Aco2 Sdhc Fh Suclg1 Pdk2 THREONINE BIOSYNTHESIS%PANTHER PATHWAY%P02781 Threonine biosynthesis Thnsl1 INTERLEUKIN SIGNALING PATHWAY%PANTHER PATHWAY%P00036 Interleukin signaling pathway Cxcr2 Mapk6 Elk4 Srf Rps6ka3 Irs2 Rps6ka1 Araf Irs1 Elk1 Fos Raf1 Mtor Cxcr1 Mknk2 Stat3 Mknk1 Stat1 Nos3 Gsk3b Mapk15 Foxo3 Rasa1 Rps6ka6 Rps6ka2 Stat2 Spic Elk3 Stat6 Il11 Cdkn1a Il11ra1 Sos1 Il9 Pdpk1 Il4 Il6 Sla2 Myc Il13ra1 Il13ra2 Mapk1 Mapkapk2 Shc1 Akt2 Pik3cb Il10rb Il23a Il21 Il10ra Il4r Akt3 Chuk Il6st Il20ra Spi1 Il2ra Ikbkb LOC100360218 Nras Stat5a Il3ra Il5ra Cdkn1b Jak3 Akt1 Stat5b Il12rb2 EGF RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00018 EGF receptor signaling pathway Prkcd Prkch Prkcb Prkci Ppp2r5b Rac2 Prkca Ppp2r5c Ppp2r5a Mapk9 Areg LOC100909468 Prkcq Mras Cbl Rasal2 Nf1 Tgfa Rac1 Btc Ereg Araf Prkd3 Cblb Cblc Hbegf Rras2 Prkd1 Prkd2 Map3k4 Raf1 Map3k2 Map3k3 Nrg2 Nrg1 Nrg3 Nrg4 Ywhah Sfn Spry2 Stat3 Ywhag Stat1 Spry4 Spry1 Ywhaz Egfr Map2k1 Erbb4 Mapk11 Erbb3 Map2k7 Erbb2 Pik3c2a Pik3c2b Map2k4 Map2k2 Rasa1 Shc3 Ywhae Stat2 Shc2 Mapk10 Stat6 Rras Plcg1 Sos1 Ywhab Hras Pik3r5 Map2k6 Mapk1 Mapk14 Gab2 Mapk13 Shc1 Mapk12 Gab1 Akt2 Pik3cb Ppp2cb Mapk8 Ppp2ca Pebp1 Pik3cd Akt3 Ppp2r5e Prkcz Pik3cg Nras Rasa2 Stat5a Pik3c3 Akt1 Grap Stat5b 5-HYDROXYTRYPTAMINE BIOSYNTHESIS%PANTHER PATHWAY%P04371 5-Hydroxytryptamine biosynthesis Tph2 Tph1 Ddc BLOOD COAGULATION%PANTHER PATHWAY%P00011 Blood coagulation Serpinc1 F12 App F10 Procr Gp1ba Thbd F3 Proz Serpina1 Serpina10 Proc Gp9 F2 F7 F8 Gp5 Tfpi F9 F2r Serpinb2 Plat Plg Serpinf2 Serpine1 Fga Fgb Fgg Plau Vwf Itga2b Klkb1 LOC100911551 Pros1 F13b Gp1bb ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%R-RNO-111447.1 Activation of BAD and translocation to mitochondria C-SRC MEDIATED REGULATION OF CX43 FUNCTION AND CLOSURE OF GAP JUNCTIONS%REACTOME%R-RNO-191647.1 c-src mediated regulation of Cx43 function and closure of gap junctions EUKARYOTIC TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 66%10144835 Eukaryotic Translation Initiation TIE2 SIGNALING%REACTOME%R-RNO-210993.1 Tie2 Signaling SMALL INTERFERING RNA (SIRNA) BIOGENESIS%REACTOME%R-RNO-426486.1 Small interfering RNA (siRNA) biogenesis ARACHIDONATE PRODUCTION FROM DAG%REACTOME%R-RNO-426048.1 Arachidonate production from DAG NUCLEOTIDE EXCISION REPAIR%REACTOME%R-RNO-5696398.1 Nucleotide Excision Repair CAP-DEPENDENT TRANSLATION INITIATION%REACTOME%R-RNO-72737.1 Cap-dependent Translation Initiation TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE%REACTOME%R-RNO-168188.1 Toll Like Receptor TLR6:TLR2 Cascade CARBOHYDRATE METABOLISM%REACTOME DATABASE ID RELEASE 66%10144766 Carbohydrate metabolism ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS%REACTOME%R-RNO-176187.1 Activation of ATR in response to replication stress EXTRACELLULAR MATRIX ORGANIZATION%REACTOME DATABASE ID RELEASE 66%10145031 Extracellular matrix organization LEADING STRAND SYNTHESIS%REACTOME%R-RNO-69109.1 Leading Strand Synthesis REGULATED PROTEOLYSIS OF P75NTR%REACTOME DATABASE ID RELEASE 66%10145335 Regulated proteolysis of p75NTR MISMATCH REPAIR (MMR) DIRECTED BY MSH2:MSH3 (MUTSBETA)%REACTOME%R-RNO-5358606.1 Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) NEUTROPHIL DEGRANULATION%REACTOME%R-RNO-6798695.1 Neutrophil degranulation REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA%REACTOME DATABASE ID RELEASE 66%10145918 Regulation of innate immune responses to cytosolic DNA RHO GTPASES ACTIVATE CIT%REACTOME DATABASE ID RELEASE 66%10146123 RHO GTPases activate CIT FORMATION OF INCISION COMPLEX IN GG-NER%REACTOME%R-RNO-5696395.1 Formation of Incision Complex in GG-NER NTF3 ACTIVATES NTRK3 SIGNALING%REACTOME%R-RNO-9034013.1 NTF3 activates NTRK3 signaling REMOVAL OF THE FLAP INTERMEDIATE%REACTOME DATABASE ID RELEASE 66%10144734 Removal of the Flap Intermediate THE PROTON BUFFERING MODEL%REACTOME%R-RNO-167827.1 The proton buffering model POTASSIUM TRANSPORT CHANNELS%REACTOME%R-RNO-1296067.1 Potassium transport channels RUNX2 REGULATES OSTEOBLAST DIFFERENTIATION%REACTOME%R-RNO-8940973.1 RUNX2 regulates osteoblast differentiation BUTYRATE RESPONSE FACTOR 1 (BRF1) BINDS AND DESTABILIZES MRNA%REACTOME%R-RNO-450385.1 Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA NEUROTRANSMITTER CLEARANCE%REACTOME%R-RNO-112311.1 Neurotransmitter clearance RUNX3 REGULATES YAP1-MEDIATED TRANSCRIPTION%REACTOME DATABASE ID RELEASE 66%10146278 RUNX3 regulates YAP1-mediated transcription ESTABLISHMENT OF SISTER CHROMATID COHESION%REACTOME DATABASE ID RELEASE 66%10145970 Establishment of Sister Chromatid Cohesion PRC2 METHYLATES HISTONES AND DNA%REACTOME%R-RNO-212300.1 PRC2 methylates histones and DNA FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION%REACTOME%R-RNO-434316.1 Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION%REACTOME%R-RNO-381340.1 Transcriptional regulation of white adipocyte differentiation INTERLEUKIN-20 FAMILY SIGNALING%REACTOME%R-RNO-8854691.1 Interleukin-20 family signaling RHO GTPASE EFFECTORS%REACTOME DATABASE ID RELEASE 66%10144888 RHO GTPase Effectors HDL CLEARANCE%REACTOME%R-RNO-8964011.1 HDL clearance BIOSYNTHESIS OF DHA-DERIVED SPMS%REACTOME DATABASE ID RELEASE 66%10146302 Biosynthesis of DHA-derived SPMs IRS-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%R-RNO-2428928.1 IRS-related events triggered by IGF1R INSULIN RECEPTOR SIGNALLING CASCADE%REACTOME DATABASE ID RELEASE 66%10144875 Insulin receptor signalling cascade P2Y RECEPTORS%REACTOME%R-RNO-417957.1 P2Y receptors REGULATION OF ORNITHINE DECARBOXYLASE (ODC)%REACTOME DATABASE ID RELEASE 66%10145465 Regulation of ornithine decarboxylase (ODC) TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS%REACTOME%R-RNO-174417.1 Telomere C-strand (Lagging Strand) Synthesis PROTON-COUPLED MONOCARBOXYLATE TRANSPORT%REACTOME DATABASE ID RELEASE 66%10145649 Proton-coupled monocarboxylate transport INSULIN EFFECTS INCREASED SYNTHESIS OF XYLULOSE-5-PHOSPHATE%REACTOME%R-RNO-163754.1 Insulin effects increased synthesis of Xylulose-5-Phosphate TRANSPORT OF NUCLEOSIDES AND FREE PURINE AND PYRIMIDINE BASES ACROSS THE PLASMA MEMBRANE%REACTOME%R-RNO-83936.1 Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane METHYLATION%REACTOME DATABASE ID RELEASE 66%10144922 Methylation GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION%REACTOME%R-RNO-381676.1 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion CHYLOMICRON ASSEMBLY%REACTOME DATABASE ID RELEASE 66%10145238 Chylomicron assembly MYD88-INDEPENDENT TLR4 CASCADE%REACTOME%R-RNO-166166.1 MyD88-independent TLR4 cascade HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145724 Highly calcium permeable postsynaptic nicotinic acetylcholine receptors G ALPHA (12 13) SIGNALLING EVENTS%REACTOME%R-RNO-416482.1 G alpha (12 13) signalling events EPHRIN SIGNALING%REACTOME%R-RNO-3928664.1 Ephrin signaling METABOLISM OF NITRIC OXIDE%REACTOME DATABASE ID RELEASE 66%10145396 Metabolism of nitric oxide SUMOYLATION OF UBIQUITINYLATION PROTEINS%REACTOME%R-RNO-3232142.1 SUMOylation of ubiquitinylation proteins SIGNALING BY TGF-BETA RECEPTOR COMPLEX%REACTOME%R-RNO-170834.1 Signaling by TGF-beta Receptor Complex SIGNALING BY HEDGEHOG%REACTOME%R-RNO-5358351.1 Signaling by Hedgehog GABA A (RHO) RECEPTOR ACTIVATION%REACTOME DATABASE ID RELEASE 66%10145776 GABA A (rho) receptor activation SYNTHESIS OF PIPS IN THE NUCLEUS%REACTOME%R-RNO-8847453.1 Synthesis of PIPs in the nucleus TP53 REGULATES METABOLIC GENES%REACTOME DATABASE ID RELEASE 66%10144779 TP53 Regulates Metabolic Genes VLDL ASSEMBLY%REACTOME%R-RNO-8866423.1 VLDL assembly GLYCOSPHINGOLIPID METABOLISM%REACTOME%R-RNO-1660662.1 Glycosphingolipid metabolism PCP CE PATHWAY%REACTOME%R-RNO-4086400.1 PCP CE pathway OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA%REACTOME%R-RNO-1234176.1 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha OREXIN AND NEUROPEPTIDES FF AND QRFP BIND TO THEIR RESPECTIVE RECEPTORS%REACTOME%R-RNO-389397.1 Orexin and neuropeptides FF and QRFP bind to their respective receptors REGULATION OF TP53 EXPRESSION AND DEGRADATION%REACTOME%R-RNO-6806003.1 Regulation of TP53 Expression and Degradation METABOLISM OF SEROTONIN%REACTOME%R-RNO-380612.1 Metabolism of serotonin ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION%REACTOME DATABASE ID RELEASE 66%10145589 Adrenaline,noradrenaline inhibits insulin secretion DECTIN-1 MEDIATED NONCANONICAL NF-KB SIGNALING%REACTOME%R-RNO-5607761.1 Dectin-1 mediated noncanonical NF-kB signaling NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME DATABASE ID RELEASE 66%10145920 NOTCH2 Activation and Transmission of Signal to the Nucleus ESTROGEN-DEPENDENT GENE EXPRESSION%REACTOME%R-RNO-9018519.1 Estrogen-dependent gene expression TRIGLYCERIDE METABOLISM%REACTOME%R-RNO-8979227.1 Triglyceride metabolism P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME%R-RNO-372708.1 p130Cas linkage to MAPK signaling for integrins PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145719 Presynaptic nicotinic acetylcholine receptors PRE-MRNA SPLICING%REACTOME DATABASE ID RELEASE 66%10144828 pre-mRNA splicing BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS%REACTOME DATABASE ID RELEASE 66%10145554 Beta-oxidation of very long chain fatty acids PKMTS METHYLATE HISTONE LYSINES%REACTOME DATABASE ID RELEASE 66%10146041 PKMTs methylate histone lysines CHROMATIN MODIFYING ENZYMES%REACTOME%R-RNO-3247509.1 Chromatin modifying enzymes LGI-ADAM INTERACTIONS%REACTOME%R-RNO-5682910.1 LGI-ADAM interactions TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION%REACTOME DATABASE ID RELEASE 66%10145151 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7 8 or 9 activation METHIONINE SALVAGE PATHWAY%REACTOME DATABASE ID RELEASE 66%10145821 Methionine salvage pathway METABOLISM OF LIPIDS%REACTOME%R-RNO-556833.1 Metabolism of lipids INWARDLY RECTIFYING K+ CHANNELS%REACTOME DATABASE ID RELEASE 66%10145793 Inwardly rectifying K+ channels TFAP2 (AP-2) FAMILY REGULATES TRANSCRIPTION OF GROWTH FACTORS AND THEIR RECEPTORS%REACTOME%R-RNO-8866910.1 TFAP2 (AP-2) family regulates transcription of growth factors and their receptors SIGNALING BY ROBO RECEPTORS%REACTOME%R-RNO-376176.1 Signaling by ROBO receptors ORGANIC ANION TRANSPORTERS%REACTOME DATABASE ID RELEASE 66%10145484 Organic anion transporters AXONAL GROWTH INHIBITION (RHOA ACTIVATION)%REACTOME%R-RNO-193634.1 Axonal growth inhibition (RHOA activation) DOWNREGULATION OF ERBB2 SIGNALING%REACTOME%R-RNO-8863795.1 Downregulation of ERBB2 signaling ROS, RNS PRODUCTION IN PHAGOCYTES%REACTOME DATABASE ID RELEASE 66%10145602 ROS, RNS production in phagocytes GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME%R-RNO-354194.1 GRB2:SOS provides linkage to MAPK signaling for Integrins AMPLIFICATION OF SIGNAL FROM UNATTACHED KINETOCHORES VIA A MAD2 INHIBITORY SIGNAL%REACTOME DATABASE ID RELEASE 66%10145062 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal GDP-FUCOSE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 66%10145727 GDP-fucose biosynthesis REGULATION OF SIGNALING BY CBL%REACTOME%R-RNO-912631.1 Regulation of signaling by CBL CALNEXIN CALRETICULIN CYCLE%REACTOME DATABASE ID RELEASE 66%10145711 Calnexin calreticulin cycle COLLAGEN CHAIN TRIMERIZATION%REACTOME DATABASE ID RELEASE 66%10145922 Collagen chain trimerization SHC-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%R-RNO-2428933.1 SHC-related events triggered by IGF1R RAS ACTIVATION UPON CA2+ INFLUX THROUGH NMDA RECEPTOR%REACTOME%R-RNO-442982.1 Ras activation upon Ca2+ influx through NMDA receptor FRS-MEDIATED FGFR1 SIGNALING%REACTOME DATABASE ID RELEASE 66%10146102 FRS-mediated FGFR1 signaling MASTL FACILITATES MITOTIC PROGRESSION%REACTOME%R-RNO-2465910.1 MASTL Facilitates Mitotic Progression SYNTHESIS OF PE%REACTOME%R-RNO-1483213.1 Synthesis of PE INOSITOL TRANSPORTERS%REACTOME DATABASE ID RELEASE 66%10145635 Inositol transporters PHOSPHOLIPID METABOLISM%REACTOME%R-RNO-1483257.1 Phospholipid metabolism BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN%REACTOME%R-RNO-446193.1 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein BBSOME-MEDIATED CARGO-TARGETING TO CILIUM%REACTOME DATABASE ID RELEASE 66%10146078 BBSome-mediated cargo-targeting to cilium ACYL CHAIN REMODELLING OF PE%REACTOME%R-RNO-1482839.1 Acyl chain remodelling of PE RESOLUTION OF ABASIC SITES (AP SITES)%REACTOME%R-RNO-73933.1 Resolution of Abasic Sites (AP sites) ACTIVATION OF AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145580 Activation of AMPA receptors ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS%REACTOME%R-RNO-2122948.1 Activated NOTCH1 Transmits Signal to the Nucleus SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX)%REACTOME DATABASE ID RELEASE 66%10145441 Synthesis of Leukotrienes (LT) and Eoxins (EX) METABOLISM OF VITAMIN K%REACTOME%R-RNO-6806664.1 Metabolism of vitamin K OVARIAN TUMOR DOMAIN PROTEASES%REACTOME%R-RNO-5689896.1 Ovarian tumor domain proteases TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G2 CELL CYCLE ARREST%REACTOME DATABASE ID RELEASE 66%10146160 TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest EPHB-MEDIATED FORWARD SIGNALING%REACTOME DATABASE ID RELEASE 66%10146024 EPHB-mediated forward signaling APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS%REACTOME DATABASE ID RELEASE 66%10145068 APC C-mediated degradation of cell cycle proteins THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT%REACTOME DATABASE ID RELEASE 66%10144783 The citric acid (TCA) cycle and respiratory electron transport BIOTIN TRANSPORT AND METABOLISM%REACTOME DATABASE ID RELEASE 66%10145370 Biotin transport and metabolism SHC-MEDIATED CASCADE:FGFR1%REACTOME DATABASE ID RELEASE 66%10146109 SHC-mediated cascade:FGFR1 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE%REACTOME%R-RNO-77075.1 RNA Pol II CTD phosphorylation and interaction with CE AMINO ACID CONJUGATION%REACTOME DATABASE ID RELEASE 66%10145091 Amino Acid conjugation ALPHA-LINOLENIC ACID (ALA) METABOLISM%REACTOME%R-RNO-2046106.1 alpha-linolenic acid (ALA) metabolism THE PHOTOTRANSDUCTION CASCADE%REACTOME DATABASE ID RELEASE 66%10144866 The phototransduction cascade MITOCHONDRIAL FATTY ACID BETA-OXIDATION%REACTOME%R-RNO-77289.1 Mitochondrial Fatty Acid Beta-Oxidation SULFUR AMINO ACID METABOLISM%REACTOME%R-RNO-1614635.1 Sulfur amino acid metabolism NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 66%10145481 Norepinephrine Neurotransmitter Release Cycle BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145954 Binding and Uptake of Ligands by Scavenger Receptors FCERI MEDIATED CA+2 MOBILIZATION%REACTOME%R-RNO-2871809.1 FCERI mediated Ca+2 mobilization BIOSYNTHESIS OF ELECTROPHILIC Ω-3 PUFA OXO-DERIVATIVES%REACTOME DATABASE ID RELEASE 66%10146319 Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives PTEN REGULATION%REACTOME%R-RNO-6807070.1 PTEN Regulation TFAP2A ACTS AS A TRANSCRIPTIONAL REPRESSOR DURING RETINOIC ACID INDUCED CELL DIFFERENTIATION%REACTOME%R-RNO-8869496.1 TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1)%REACTOME DATABASE ID RELEASE 66%10145538 Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) TOLL LIKE RECEPTOR 4 (TLR4) CASCADE%REACTOME DATABASE ID RELEASE 66%10145130 Toll Like Receptor 4 (TLR4) Cascade ADENYLATE CYCLASE ACTIVATING PATHWAY%REACTOME DATABASE ID RELEASE 66%10145191 Adenylate cyclase activating pathway SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL%REACTOME DATABASE ID RELEASE 66%10145908 Synthesis of pyrophosphates in the cytosol NEGATIVE REGULATION OF ACTIVITY OF TFAP2 (AP-2) FAMILY TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 66%10146003 Negative regulation of activity of TFAP2 (AP-2) family transcription factors VLDL CLEARANCE%REACTOME DATABASE ID RELEASE 66%10146224 VLDL clearance RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF HSCS%REACTOME DATABASE ID RELEASE 66%10146239 RUNX1 regulates transcription of genes involved in differentiation of HSCs BIOSYNTHESIS OF DPAN-6 SPMS%REACTOME DATABASE ID RELEASE 66%10146307 Biosynthesis of DPAn-6 SPMs GROWTH HORMONE RECEPTOR SIGNALING%REACTOME DATABASE ID RELEASE 66%10145708 Growth hormone receptor signaling REUPTAKE OF GABA%REACTOME%R-RNO-888593.1 Reuptake of GABA THYROXINE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 66%10145424 Thyroxine biosynthesis PLATELET ADHESION TO EXPOSED COLLAGEN%REACTOME%R-RNO-75892.1 Platelet Adhesion to exposed collagen INITIAL TRIGGERING OF COMPLEMENT%REACTOME%R-RNO-166663.1 Initial triggering of complement FORMATION OF THE CORNIFIED ENVELOPE%REACTOME%R-RNO-6809371.1 Formation of the cornified envelope SIGNALING BY MET%REACTOME%R-RNO-6806834.1 Signaling by MET RHO GTPASES ACTIVATE FORMINS%REACTOME%R-RNO-5663220.1 RHO GTPases Activate Formins CITRIC ACID CYCLE (TCA CYCLE)%REACTOME%R-RNO-71403.1 Citric acid cycle (TCA cycle) CHAPERONIN-MEDIATED PROTEIN FOLDING%REACTOME%R-RNO-390466.1 Chaperonin-mediated protein folding KINESINS%REACTOME%R-RNO-983189.1 Kinesins SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL%REACTOME DATABASE ID RELEASE 66%10145904 Synthesis of IP3 and IP4 in the cytosol CARGO RECOGNITION FOR CLATHRIN-MEDIATED ENDOCYTOSIS%REACTOME%R-RNO-8856825.1 Cargo recognition for clathrin-mediated endocytosis ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR%REACTOME DATABASE ID RELEASE 66%10145698 Activation of Ca-permeable Kainate Receptor SIGNALING BY RHO GTPASES%REACTOME DATABASE ID RELEASE 66%10144889 Signaling by Rho GTPases OLIGOMERIZATION OF CONNEXINS INTO CONNEXONS%REACTOME DATABASE ID RELEASE 66%10145304 Oligomerization of connexins into connexons CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKK%REACTOME%R-RNO-442717.1 CREB phosphorylation through the activation of CaMKK PEPTIDE CHAIN ELONGATION%REACTOME%R-RNO-156902.1 Peptide chain elongation CLASS B 2 (SECRETIN FAMILY RECEPTORS)%REACTOME%R-RNO-373080.1 Class B 2 (Secretin family receptors) ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME DATABASE ID RELEASE 66%10145219 Activation of APC C and APC C:Cdc20 mediated degradation of mitotic proteins IRE1ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 66%10145532 IRE1alpha activates chaperones RHESUS GLYCOPROTEINS MEDIATE AMMONIUM TRANSPORT.%REACTOME DATABASE ID RELEASE 66%10145662 Rhesus glycoproteins mediate ammonium transport. RNA POLYMERASE I TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 66%10144885 RNA Polymerase I Transcription Termination APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B%REACTOME%R-RNO-174048.1 APC C:Cdc20 mediated degradation of Cyclin B MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME%REACTOME%R-RNO-975155.1 MyD88 dependent cascade initiated on endosome DSCAM INTERACTIONS%REACTOME%R-RNO-376172.1 DSCAM interactions MISCELLANEOUS TRANSPORT AND BINDING EVENTS%REACTOME%R-RNO-5223345.1 Miscellaneous transport and binding events MITOCHONDRIAL TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 66%10145117 Mitochondrial transcription initiation PINK PARKIN MEDIATED MITOPHAGY%REACTOME DATABASE ID RELEASE 66%10146045 Pink Parkin Mediated Mitophagy SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R)%REACTOME%R-RNO-2404192.1 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) INTERCONVERSION OF POLYAMINES%REACTOME DATABASE ID RELEASE 66%10145061 Interconversion of polyamines NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%R-RNO-2122947.1 NOTCH1 Intracellular Domain Regulates Transcription ELECTRIC TRANSMISSION ACROSS GAP JUNCTIONS%REACTOME DATABASE ID RELEASE 66%10145507 Electric Transmission Across Gap Junctions THE NLRP3 INFLAMMASOME%REACTOME%R-RNO-844456.1 The NLRP3 inflammasome FCGR ACTIVATION%REACTOME DATABASE ID RELEASE 66%10145910 FCGR activation SLIT2:ROBO1 INCREASES RHOA ACTIVITY%REACTOME DATABASE ID RELEASE 66%10146285 SLIT2:ROBO1 increases RHOA activity TICAM1-DEPENDENT ACTIVATION OF IRF3 IRF7%REACTOME DATABASE ID RELEASE 66%10145179 TICAM1-dependent activation of IRF3 IRF7 COX REACTIONS%REACTOME DATABASE ID RELEASE 66%10145051 COX reactions SIGNALING BY VEGF%REACTOME DATABASE ID RELEASE 66%10145273 Signaling by VEGF REGULATION OF MECP2 EXPRESSION AND ACTIVITY%REACTOME%R-RNO-9022692.1 Regulation of MECP2 expression and activity ACTIVATION OF TRKA RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145141 Activation of TRKA receptors DOWNSTREAM SIGNALING OF ACTIVATED FGFR2%REACTOME DATABASE ID RELEASE 66%10145255 Downstream signaling of activated FGFR2 VASOPRESSIN-LIKE RECEPTORS%REACTOME%R-RNO-388479.1 Vasopressin-like receptors ANCHORING OF THE BASAL BODY TO THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 66%10146081 Anchoring of the basal body to the plasma membrane ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION%REACTOME%R-RNO-2730905.1 Role of LAT2 NTAL LAB on calcium mobilization NEPHRIN FAMILY INTERACTIONS%REACTOME%R-RNO-373753.1 Nephrin family interactions IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX%REACTOME%R-RNO-937042.1 IRAK2 mediated activation of TAK1 complex PYRIMIDINE SALVAGE%REACTOME DATABASE ID RELEASE 66%10144845 Pyrimidine salvage TWIK-RELATED ALKALINE PH ACTIVATED K+ CHANNEL (TALK)%REACTOME DATABASE ID RELEASE 66%10145847 TWIK-related alkaline pH activated K+ channel (TALK) THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS)%REACTOME%R-RNO-456926.1 Thrombin signalling through proteinase activated receptors (PARs) DEADENYLATION OF MRNA%REACTOME DATABASE ID RELEASE 66%10145638 Deadenylation of mRNA FORMYL PEPTIDE RECEPTORS BIND FORMYL PEPTIDES AND MANY OTHER LIGANDS%REACTOME DATABASE ID RELEASE 66%10145663 Formyl peptide receptors bind formyl peptides and many other ligands ACTIVATION AND OLIGOMERIZATION OF BAK PROTEIN%REACTOME DATABASE ID RELEASE 66%10145015 Activation and oligomerization of BAK protein A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS%REACTOME%R-RNO-1971475.1 A tetrasaccharide linker sequence is required for GAG synthesis PKA ACTIVATION IN GLUCAGON SIGNALLING%REACTOME%R-RNO-164378.1 PKA activation in glucagon signalling CLASS C 3 (METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS)%REACTOME DATABASE ID RELEASE 66%10145488 Class C 3 (Metabotropic glutamate pheromone receptors) CA-DEPENDENT EVENTS%REACTOME DATABASE ID RELEASE 66%10144989 Ca-dependent events SUMOYLATION OF RNA BINDING PROTEINS%REACTOME DATABASE ID RELEASE 66%10146034 SUMOylation of RNA binding proteins VITAMIN B5 (PANTOTHENATE) METABOLISM%REACTOME%R-RNO-199220.1 Vitamin B5 (pantothenate) metabolism ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING%REACTOME%R-RNO-451326.1 Activation of kainate receptors upon glutamate binding TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS%REACTOME DATABASE ID RELEASE 66%10145878 Transcriptional activation of mitochondrial biogenesis DOWNSTREAM SIGNALING OF ACTIVATED FGFR1%REACTOME%R-RNO-5654687.1 Downstream signaling of activated FGFR1 TRP CHANNELS%REACTOME%R-RNO-3295583.1 TRP channels SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION%REACTOME%R-RNO-2173796.1 SMAD2 SMAD3:SMAD4 heterotrimer regulates transcription DARPP-32 EVENTS%REACTOME DATABASE ID RELEASE 66%10145005 DARPP-32 events ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON%REACTOME DATABASE ID RELEASE 66%10145137 Activation of IRF3 IRF7 mediated by TBK1 IKK epsilon GLUCAGON-TYPE LIGAND RECEPTORS%REACTOME%R-RNO-420092.1 Glucagon-type ligand receptors SUMO E3 LIGASES SUMOYLATE TARGET PROTEINS%REACTOME DATABASE ID RELEASE 66%10145992 SUMO E3 ligases SUMOylate target proteins AXON GUIDANCE%REACTOME%R-RNO-422475.1 Axon guidance SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE%REACTOME%R-RNO-416572.1 Sema4D induced cell migration and growth-cone collapse FREE FATTY ACIDS REGULATE INSULIN SECRETION%REACTOME DATABASE ID RELEASE 66%10145587 Free fatty acids regulate insulin secretion SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN%REACTOME DATABASE ID RELEASE 66%10145615 Synthesis, secretion, and deacylation of Ghrelin SIGNALING BY NOTCH3%REACTOME DATABASE ID RELEASE 66%10145952 Signaling by NOTCH3 OXYGEN-DEPENDENT ASPARAGINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA%REACTOME DATABASE ID RELEASE 66%10145810 Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha REPRODUCTION%REACTOME%R-RNO-1474165.1 Reproduction PHOSPHOLIPASE C-MEDIATED CASCADE: FGFR1%REACTOME%R-RNO-5654219.1 Phospholipase C-mediated cascade: FGFR1 MELANIN BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 66%10146119 Melanin biosynthesis DIGESTION AND ABSORPTION%REACTOME%R-RNO-8963743.1 Digestion and absorption GAP JUNCTION DEGRADATION%REACTOME DATABASE ID RELEASE 66%10145296 Gap junction degradation O-LINKED GLYCOSYLATION OF MUCINS%REACTOME%R-RNO-913709.1 O-linked glycosylation of mucins CTLA4 INHIBITORY SIGNALING%REACTOME DATABASE ID RELEASE 66%10145541 CTLA4 inhibitory signaling PENTOSE PHOSPHATE PATHWAY%REACTOME%R-RNO-71336.1 Pentose phosphate pathway UBIQUINOL BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 66%10145949 Ubiquinol biosynthesis PHASE I - FUNCTIONALIZATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 66%10144820 Phase I - Functionalization of compounds PRESYNAPTIC PHASE OF HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME DATABASE ID RELEASE 66%10146131 Presynaptic phase of homologous DNA pairing and strand exchange SLC-MEDIATED TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 66%10144952 SLC-mediated transmembrane transport ASYMMETRIC LOCALIZATION OF PCP PROTEINS%REACTOME%R-RNO-4608870.1 Asymmetric localization of PCP proteins ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12%REACTOME%R-RNO-392170.1 ADP signalling through P2Y purinoceptor 12 SIGNALING BY TGF-BETA FAMILY MEMBERS%REACTOME DATABASE ID RELEASE 66%10145195 Signaling by TGF-beta family members MITOTIC G2-G2 M PHASES%REACTOME DATABASE ID RELEASE 66%10145075 Mitotic G2-G2 M phases SIGNALLING TO ERK5%REACTOME DATABASE ID RELEASE 66%10145365 Signalling to ERK5 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS.%REACTOME%R-RNO-163200.1 Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. MYD88:MAL(TIRAP) CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME%R-RNO-166058.1 MyD88:MAL(TIRAP) cascade initiated on plasma membrane FORMATION OF THE ACTIVE COFACTOR, UDP-GLUCURONATE%REACTOME DATABASE ID RELEASE 66%10144771 Formation of the active cofactor, UDP-glucuronate GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK%REACTOME DATABASE ID RELEASE 66%10145366 Gastrin-CREB signalling pathway via PKC and MAPK INTRACELLULAR OXYGEN TRANSPORT%REACTOME%R-RNO-8981607.1 Intracellular oxygen transport NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS%REACTOME DATABASE ID RELEASE 66%10145178 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways VITAMINS B6 ACTIVATION TO PYRIDOXAL PHOSPHATE%REACTOME%R-RNO-964975.1 Vitamins B6 activation to pyridoxal phosphate SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION%REACTOME DATABASE ID RELEASE 66%10145592 Sema4D mediated inhibition of cell attachment and migration WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2%REACTOME%R-RNO-5140745.1 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME%R-RNO-110381.1 Resolution of AP sites via the single-nucleotide replacement pathway SCAVENGING BY CLASS B RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145958 Scavenging by Class B Receptors REGULATION OF TLR BY ENDOGENOUS LIGAND%REACTOME DATABASE ID RELEASE 66%10146066 Regulation of TLR by endogenous ligand NOTCH-HLH TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 66%10145446 Notch-HLH transcription pathway VITAMINS%REACTOME%R-RNO-211916.1 Vitamins UCH PROTEINASES%REACTOME DATABASE ID RELEASE 66%10146120 UCH proteinases ADRENOCEPTORS%REACTOME%R-RNO-390696.1 Adrenoceptors REGULATION OF TP53 EXPRESSION%REACTOME DATABASE ID RELEASE 66%10146179 Regulation of TP53 Expression POST-TRANSLATIONAL PROTEIN MODIFICATION%REACTOME%R-RNO-597592.1 Post-translational protein modification FGFR1B LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 66%10145285 FGFR1b ligand binding and activation HOMOLOGY DIRECTED REPAIR%REACTOME DATABASE ID RELEASE 66%10144914 Homology Directed Repair TRANSCRIPTION-COUPLED NUCLEOTIDE EXCISION REPAIR (TC-NER)%REACTOME%R-RNO-6781827.1 Transcription-Coupled Nucleotide Excision Repair (TC-NER) TRANSCRIPTIONAL REGULATION BY RUNX2%REACTOME DATABASE ID RELEASE 66%10146258 Transcriptional regulation by RUNX2 PRE-NOTCH PROCESSING IN GOLGI%REACTOME%R-RNO-1912420.1 Pre-NOTCH Processing in Golgi CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA%REACTOME DATABASE ID RELEASE 66%10145175 Cytosolic sensors of pathogen-associated DNA HDL ASSEMBLY%REACTOME DATABASE ID RELEASE 66%10145449 HDL assembly ERYTHROCYTES TAKE UP OXYGEN AND RELEASE CARBON DIOXIDE%REACTOME DATABASE ID RELEASE 66%10145820 Erythrocytes take up oxygen and release carbon dioxide REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN%REACTOME%R-RNO-1234174.1 Regulation of Hypoxia-inducible Factor (HIF) by oxygen PHASE 2 - PLATEAU PHASE%REACTOME%R-RNO-5576893.1 Phase 2 - plateau phase GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER%REACTOME%R-RNO-6782210.1 Gap-filling DNA repair synthesis and ligation in TC-NER RHO GTPASE CYCLE%REACTOME DATABASE ID RELEASE 66%10145340 Rho GTPase cycle GLUTATHIONE CONJUGATION%REACTOME%R-RNO-156590.1 Glutathione conjugation PTK6 DOWN-REGULATION%REACTOME DATABASE ID RELEASE 66%10146208 PTK6 Down-Regulation TP53 REGULATES TRANSCRIPTION OF SEVERAL ADDITIONAL CELL DEATH GENES WHOSE SPECIFIC ROLES IN P53-DEPENDENT APOPTOSIS REMAIN UNCERTAIN%REACTOME DATABASE ID RELEASE 66%10146175 TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain CYCLIN A B1 B2 ASSOCIATED EVENTS DURING G2 M TRANSITION%REACTOME%R-RNO-69273.1 Cyclin A B1 B2 associated events during G2 M transition SPHINGOLIPID METABOLISM%REACTOME%R-RNO-428157.1 Sphingolipid metabolism SPERM:OOCYTE MEMBRANE BINDING%REACTOME DATABASE ID RELEASE 66%10145840 Sperm:Oocyte Membrane Binding CRISTAE FORMATION%REACTOME%R-RNO-8949613.1 Cristae formation AROMATIC AMINES CAN BE N-HYDROXYLATED OR N-DEALKYLATED BY CYP1A2%REACTOME%R-RNO-211957.1 Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 ABACAVIR TRANSPORT AND METABOLISM%REACTOME DATABASE ID RELEASE 66%10145942 Abacavir transport and metabolism REGULATION OF CYTOSKELETAL REMODELING AND CELL SPREADING BY IPP COMPLEX COMPONENTS%REACTOME DATABASE ID RELEASE 66%10145641 Regulation of cytoskeletal remodeling and cell spreading by IPP complex components PHOSPHOLIPASE C-MEDIATED CASCADE; FGFR3%REACTOME DATABASE ID RELEASE 66%10146099 Phospholipase C-mediated cascade; FGFR3 RAF MAP KINASE CASCADE%REACTOME%R-RNO-5673001.1 RAF MAP kinase cascade ABASIC SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 66%10144981 Abasic sugar-phosphate removal via the single-nucleotide replacement pathway CRMPS IN SEMA3A SIGNALING%REACTOME%R-RNO-399956.1 CRMPs in Sema3A signaling REGULATION OF TP53 ACTIVITY THROUGH ACETYLATION%REACTOME DATABASE ID RELEASE 66%10146001 Regulation of TP53 Activity through Acetylation BIOSYNTHESIS OF MARESINS%REACTOME%R-RNO-9018682.1 Biosynthesis of maresins TP53 REGULATES TRANSCRIPTION OF CELL CYCLE GENES%REACTOME%R-RNO-6791312.1 TP53 Regulates Transcription of Cell Cycle Genes PLC BETA MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 66%10144985 PLC beta mediated events REGULATION OF EXPRESSION OF SLITS AND ROBOS%REACTOME DATABASE ID RELEASE 66%10146286 Regulation of expression of SLITs and ROBOs GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION%REACTOME DATABASE ID RELEASE 66%10145475 GABA synthesis, release, reuptake and degradation INTEGRIN ALPHAIIB BETA3 SIGNALING%REACTOME DATABASE ID RELEASE 66%10145476 Integrin alphaIIb beta3 signaling FCERI MEDIATED MAPK ACTIVATION%REACTOME DATABASE ID RELEASE 66%10145166 FCERI mediated MAPK activation PTK6 ACTIVATES STAT3%REACTOME DATABASE ID RELEASE 66%10146200 PTK6 Activates STAT3 CLEC7A INFLAMMASOME PATHWAY%REACTOME%R-RNO-5660668.1 CLEC7A inflammasome pathway SIGNALING BY NTRK1 (TRKA)%REACTOME%R-RNO-187037.1 Signaling by NTRK1 (TRKA) PEPTIDE HORMONE METABOLISM%REACTOME%R-RNO-2980736.1 Peptide hormone metabolism CELL CYCLE%REACTOME DATABASE ID RELEASE 66%10144722 Cell Cycle TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G1 CELL CYCLE ARREST%REACTOME%R-RNO-6804116.1 TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest INTERLEUKIN-2 SIGNALING%REACTOME%R-RNO-9020558.1 Interleukin-2 signaling DEPURINATION%REACTOME DATABASE ID RELEASE 66%10144975 Depurination G2 M DNA REPLICATION CHECKPOINT%REACTOME%R-RNO-69478.1 G2 M DNA replication checkpoint FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX%REACTOME DATABASE ID RELEASE 66%10145392 Formation of the beta-catenin:TCF transactivating complex ACTIVATION OF THE TFAP2 (AP-2) FAMILY OF TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 66%10146233 Activation of the TFAP2 (AP-2) family of transcription factors ATF6 (ATF6-ALPHA) ACTIVATES CHAPERONES%REACTOME%R-RNO-381033.1 ATF6 (ATF6-alpha) activates chaperones SHC-MEDIATED CASCADE:FGFR2%REACTOME%R-RNO-5654699.1 SHC-mediated cascade:FGFR2 G1 PHASE%REACTOME%R-RNO-69236.1 G1 Phase SYNTHESIS OF CL%REACTOME DATABASE ID RELEASE 66%10145873 Synthesis of CL SIGNALING BY PDGF%REACTOME DATABASE ID RELEASE 66%10145268 Signaling by PDGF SIGNALING BY FGFR%REACTOME DATABASE ID RELEASE 66%10145253 Signaling by FGFR FRS-MEDIATED FGFR3 SIGNALING%REACTOME%R-RNO-5654706.1 FRS-mediated FGFR3 signaling ACTIVATION OF DNA FRAGMENTATION FACTOR%REACTOME DATABASE ID RELEASE 66%10145439 Activation of DNA fragmentation factor CASPASE ACTIVATION VIA EXTRINSIC APOPTOTIC SIGNALLING PATHWAY%REACTOME%R-RNO-5357769.1 Caspase activation via extrinsic apoptotic signalling pathway INTERLEUKIN-21 SIGNALING%REACTOME%R-RNO-9020958.1 Interleukin-21 signaling BETA-CATENIN INDEPENDENT WNT SIGNALING%REACTOME DATABASE ID RELEASE 66%10145579 Beta-catenin independent WNT signaling PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS%REACTOME%R-RNO-73817.1 Purine ribonucleoside monophosphate biosynthesis GRB7 EVENTS IN ERBB2 SIGNALING%REACTOME%R-RNO-1306955.1 GRB7 events in ERBB2 signaling DEFENSINS%REACTOME%R-RNO-1461973.1 Defensins RUNX2 REGULATES BONE DEVELOPMENT%REACTOME DATABASE ID RELEASE 66%10146257 RUNX2 regulates bone development PROPIONYL-COA CATABOLISM%REACTOME DATABASE ID RELEASE 66%10144800 Propionyl-CoA catabolism KANDUTSCH-RUSSELL PATHWAY%REACTOME DATABASE ID RELEASE 66%10146182 Kandutsch-Russell pathway COMPLEMENT CASCADE%REACTOME%R-RNO-166658.1 Complement cascade MYD88 CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 66%10145155 MyD88 cascade initiated on plasma membrane INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS%REACTOME%R-RNO-141405.1 Inhibition of the proteolytic activity of APC C required for the onset of anaphase by mitotic spindle checkpoint components INTESTINAL HEXOSE ABSORPTION%REACTOME%R-RNO-8981373.1 Intestinal hexose absorption DOPAMINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME%R-RNO-212676.1 Dopamine Neurotransmitter Release Cycle MET ACTIVATES RAS SIGNALING%REACTOME DATABASE ID RELEASE 66%10146212 MET activates RAS signaling DAP12 SIGNALING%REACTOME DATABASE ID RELEASE 66%10145432 DAP12 signaling GAB1 SIGNALOSOME%REACTOME DATABASE ID RELEASE 66%10145248 GAB1 signalosome RIPK1-MEDIATED REGULATED NECROSIS%REACTOME%R-RNO-5213460.1 RIPK1-mediated regulated necrosis REGULATION OF PTEN GENE TRANSCRIPTION%REACTOME%R-RNO-8943724.1 Regulation of PTEN gene transcription AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1%REACTOME DATABASE ID RELEASE 66%10145450 Autodegradation of the E3 ubiquitin ligase COP1 GENE EXPRESSION (TRANSCRIPTION)%REACTOME DATABASE ID RELEASE 66%10144751 Gene expression (Transcription) MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES%REACTOME%R-RNO-450282.1 MAPK targets Nuclear events mediated by MAP kinases RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER%REACTOME%R-RNO-76071.1 RNA Polymerase III Transcription Initiation From Type 3 Promoter HSF1-DEPENDENT TRANSACTIVATION%REACTOME%R-RNO-3371571.1 HSF1-dependent transactivation DOWNSTREAM TCR SIGNALING%REACTOME DATABASE ID RELEASE 66%10145375 Downstream TCR signaling P75NTR RECRUITS SIGNALLING COMPLEXES%REACTOME%R-RNO-209543.1 p75NTR recruits signalling complexes CHOLESTEROL BIOSYNTHESIS%REACTOME%R-RNO-191273.1 Cholesterol biosynthesis MEMBRANE TRAFFICKING%REACTOME DATABASE ID RELEASE 66%10145299 Membrane Trafficking HIGHLY CALCIUM PERMEABLE NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%R-RNO-629597.1 Highly calcium permeable nicotinic acetylcholine receptors PHASE 1 - INACTIVATION OF FAST NA+ CHANNELS%REACTOME DATABASE ID RELEASE 66%10146070 Phase 1 - inactivation of fast Na+ channels TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR%REACTOME DATABASE ID RELEASE 66%10145903 Trafficking and processing of endosomal TLR INTEGRATION OF ENERGY METABOLISM%REACTOME%R-RNO-163685.1 Integration of energy metabolism INTERLEUKIN-10 SIGNALING%REACTOME DATABASE ID RELEASE 66%10145687 Interleukin-10 signaling MITOTIC ANAPHASE%REACTOME DATABASE ID RELEASE 66%10145224 Mitotic Anaphase ZINC EFFLUX AND COMPARTMENTALIZATION BY THE SLC30 FAMILY%REACTOME DATABASE ID RELEASE 66%10145653 Zinc efflux and compartmentalization by the SLC30 family GABA A RECEPTOR ACTIVATION%REACTOME%R-RNO-977441.1 GABA A receptor activation INTESTINAL ABSORPTION%REACTOME DATABASE ID RELEASE 66%10145282 Intestinal absorption DEADENYLATION-DEPENDENT MRNA DECAY%REACTOME%R-RNO-429914.1 Deadenylation-dependent mRNA decay EPH-EPHRIN MEDIATED REPULSION OF CELLS%REACTOME%R-RNO-3928665.1 EPH-ephrin mediated repulsion of cells ADRENALINE SIGNALLING THROUGH ALPHA-2 ADRENERGIC RECEPTOR%REACTOME DATABASE ID RELEASE 66%10145560 Adrenaline signalling through Alpha-2 adrenergic receptor MINERALOCORTICOID BIOSYNTHESIS%REACTOME%R-RNO-193993.1 Mineralocorticoid biosynthesis BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 66%10144858 Base Excision Repair INTERLEUKIN-2 FAMILY SIGNALING%REACTOME DATABASE ID RELEASE 66%10145686 Interleukin-2 family signaling POST-TRANSLATIONAL PROTEIN PHOSPHORYLATION%REACTOME DATABASE ID RELEASE 66%10146280 Post-translational protein phosphorylation CELLULAR RESPONSES TO STRESS%REACTOME%R-RNO-2262752.1 Cellular responses to stress RECYCLING OF BILE ACIDS AND SALTS%REACTOME%R-RNO-159418.1 Recycling of bile acids and salts METAL ION SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 66%10145650 Metal ion SLC transporters UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D%REACTOME%R-RNO-75815.1 Ubiquitin-dependent degradation of Cyclin D SIGNALING BY FGFR4%REACTOME DATABASE ID RELEASE 66%10145262 Signaling by FGFR4 SODIUM CALCIUM EXCHANGERS%REACTOME DATABASE ID RELEASE 66%10145617 Sodium Calcium exchangers POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE%REACTOME%R-RNO-174411.1 Polymerase switching on the C-strand of the telomere INTERLEUKIN RECEPTOR SHC SIGNALING%REACTOME%R-RNO-912526.1 Interleukin receptor SHC signaling REGULATION OF KIT SIGNALING%REACTOME%R-RNO-1433559.1 Regulation of KIT signaling TRAF6 MEDIATED NF-KB ACTIVATION%REACTOME%R-RNO-933542.1 TRAF6 mediated NF-kB activation REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS%REACTOME%R-RNO-450531.1 Regulation of mRNA stability by proteins that bind AU-rich elements ANDROGEN BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 66%10145322 Androgen biosynthesis ACYL CHAIN REMODELLING OF PI%REACTOME%R-RNO-1482922.1 Acyl chain remodelling of PI GLUCURONIDATION%REACTOME%R-RNO-156588.1 Glucuronidation SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS%REACTOME%R-RNO-446219.1 Synthesis of substrates in N-glycan biosythesis FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION%REACTOME%R-RNO-983231.1 Factors involved in megakaryocyte development and platelet production MRNA SPLICING%REACTOME DATABASE ID RELEASE 66%10144829 mRNA Splicing FRUCTOSE CATABOLISM%REACTOME%R-RNO-70350.1 Fructose catabolism METABOLISM OF FAT-SOLUBLE VITAMINS%REACTOME DATABASE ID RELEASE 66%10145778 Metabolism of fat-soluble vitamins NGF PROCESSING%REACTOME DATABASE ID RELEASE 66%10145269 NGF processing BETA-CATENIN PHOSPHORYLATION CASCADE%REACTOME%R-RNO-196299.1 Beta-catenin phosphorylation cascade SYNDECAN INTERACTIONS%REACTOME%R-RNO-3000170.1 Syndecan interactions MET RECEPTOR RECYCLING%REACTOME DATABASE ID RELEASE 66%10146253 MET receptor recycling IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX%REACTOME DATABASE ID RELEASE 66%10144904 Import of palmitoyl-CoA into the mitochondrial matrix COSTIMULATION BY THE CD28 FAMILY%REACTOME DATABASE ID RELEASE 66%10145355 Costimulation by the CD28 family G1 S TRANSITION%REACTOME DATABASE ID RELEASE 66%10144724 G1 S Transition PHOSPHO-PLA2 PATHWAY%REACTOME DATABASE ID RELEASE 66%10144988 phospho-PLA2 pathway NRAGE SIGNALS DEATH THROUGH JNK%REACTOME%R-RNO-193648.1 NRAGE signals death through JNK HDR THROUGH HOMOLOGOUS RECOMBINATION (HRR)%REACTOME%R-RNO-5685942.1 HDR through Homologous Recombination (HRR) N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE%REACTOME%R-RNO-532668.1 N-glycan trimming in the ER and Calnexin Calreticulin cycle IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL%REACTOME%R-RNO-198933.1 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell GAMMA-CARBOXYLATION, TRANSPORT, AND AMINO-TERMINAL CLEAVAGE OF PROTEINS%REACTOME DATABASE ID RELEASE 66%10145094 Gamma-carboxylation, transport, and amino-terminal cleavage of proteins NOTCH4 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME DATABASE ID RELEASE 66%10146329 NOTCH4 Activation and Transmission of Signal to the Nucleus PHOSPHATE BOND HYDROLYSIS BY NUDT PROTEINS%REACTOME DATABASE ID RELEASE 66%10145964 Phosphate bond hydrolysis by NUDT proteins NON-INTEGRIN MEMBRANE-ECM INTERACTIONS%REACTOME DATABASE ID RELEASE 66%10145963 Non-integrin membrane-ECM interactions MITOTIC METAPHASE ANAPHASE TRANSITION%REACTOME DATABASE ID RELEASE 66%10145108 Mitotic Metaphase Anaphase Transition CILIUM ASSEMBLY%REACTOME DATABASE ID RELEASE 66%10146080 Cilium Assembly BETA OXIDATION OF MYRISTOYL-COA TO LAUROYL-COA%REACTOME%R-RNO-77285.1 Beta oxidation of myristoyl-CoA to lauroyl-CoA CELLULAR HEXOSE TRANSPORT%REACTOME%R-RNO-189200.1 Cellular hexose transport CARGO CONCENTRATION IN THE ER%REACTOME DATABASE ID RELEASE 66%10146150 Cargo concentration in the ER BIOSYNTHESIS OF SPECIALIZED PRORESOLVING MEDIATORS (SPMS)%REACTOME%R-RNO-9018678.1 Biosynthesis of specialized proresolving mediators (SPMs) DOWNSTREAM SIGNALING OF ACTIVATED FGFR3%REACTOME%R-RNO-5654708.1 Downstream signaling of activated FGFR3 BIOSYNTHESIS OF DHA-DERIVED SULFIDO CONJUGATES%REACTOME%R-RNO-9026395.1 Biosynthesis of DHA-derived sulfido conjugates LOCALIZATION OF THE PINCH-ILK-PARVIN COMPLEX TO FOCAL ADHESIONS%REACTOME%R-RNO-446343.1 Localization of the PINCH-ILK-PARVIN complex to focal adhesions ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT)%REACTOME%R-RNO-917729.1 Endosomal Sorting Complex Required For Transport (ESCRT) MAPK3 (ERK1) ACTIVATION%REACTOME%R-RNO-110056.1 MAPK3 (ERK1) activation PEPTIDE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145486 Peptide ligand-binding receptors BIOSYNTHESIS OF EPA-DERIVED SPMS%REACTOME%R-RNO-9018679.1 Biosynthesis of EPA-derived SPMs HORMONE LIGAND-BINDING RECEPTORS%REACTOME%R-RNO-375281.1 Hormone ligand-binding receptors BIOSYNTHESIS OF DPA-DERIVED SPMS%REACTOME%R-RNO-9018683.1 Biosynthesis of DPA-derived SPMs SIGNALING BY PTK6%REACTOME%R-RNO-8848021.1 Signaling by PTK6 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%R-RNO-975144.1 IRAK1 recruits IKK complex upon TLR7 8 or 9 stimulation ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS%REACTOME%R-RNO-390471.1 Association of TriC CCT with target proteins during biosynthesis NCAM SIGNALING FOR NEURITE OUT-GROWTH%REACTOME DATABASE ID RELEASE 66%10145367 NCAM signaling for neurite out-growth DOWNSTREAM SIGNAL TRANSDUCTION%REACTOME%R-RNO-186763.1 Downstream signal transduction HDR THROUGH HOMOLOGOUS RECOMBINATION (HRR) OR SINGLE STRAND ANNEALING (SSA)%REACTOME%R-RNO-5693567.1 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) NITRIC OXIDE STIMULATES GUANYLATE CYCLASE%REACTOME DATABASE ID RELEASE 66%10145601 Nitric oxide stimulates guanylate cyclase ER QUALITY CONTROL COMPARTMENT (ERQC)%REACTOME DATABASE ID RELEASE 66%10145712 ER Quality Control Compartment (ERQC) TRAFFICKING OF AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145593 Trafficking of AMPA receptors GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE%REACTOME%R-RNO-210500.1 Glutamate Neurotransmitter Release Cycle RAP1 SIGNALLING%REACTOME DATABASE ID RELEASE 66%10145480 Rap1 signalling MISMATCH REPAIR (MMR) DIRECTED BY MSH2:MSH6 (MUTSALPHA)%REACTOME DATABASE ID RELEASE 66%10146059 Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) INTERLEUKIN-36 PATHWAY%REACTOME%R-RNO-9014826.1 Interleukin-36 pathway SYNTHESIS OF PG%REACTOME%R-RNO-1483148.1 Synthesis of PG SYNTHESIS OF PI%REACTOME%R-RNO-1483226.1 Synthesis of PI SYNTHESIS OF ACTIVE UBIQUITIN: ROLES OF E1 AND E2 ENZYMES%REACTOME DATABASE ID RELEASE 66%10146214 Synthesis of active ubiquitin: roles of E1 and E2 enzymes CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE%REACTOME%R-RNO-442720.1 CREB phosphorylation through the activation of Adenylate Cyclase TNFR1-INDUCED NFKAPPAB SIGNALING PATHWAY%REACTOME DATABASE ID RELEASE 66%10146055 TNFR1-induced NFkappaB signaling pathway BIOSYNTHESIS OF MARESIN-LIKE SPMS%REACTOME DATABASE ID RELEASE 66%10146318 Biosynthesis of maresin-like SPMs CONJUGATION OF BENZOATE WITH GLYCINE%REACTOME%R-RNO-177135.1 Conjugation of benzoate with glycine ABC-FAMILY PROTEINS MEDIATED TRANSPORT%REACTOME DATABASE ID RELEASE 66%10145462 ABC-family proteins mediated transport TRANSPORT OF GLYCEROL FROM ADIPOCYTES TO THE LIVER BY AQUAPORINS%REACTOME DATABASE ID RELEASE 66%10145643 Transport of glycerol from adipocytes to the liver by Aquaporins DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE%REACTOME%R-RNO-606279.1 Deposition of new CENPA-containing nucleosomes at the centromere INTERCONVERSION OF 2-OXOGLUTARATE AND 2-HYDROXYGLUTARATE%REACTOME%R-RNO-880009.1 Interconversion of 2-oxoglutarate and 2-hydroxyglutarate HS-GAG DEGRADATION%REACTOME%R-RNO-2024096.1 HS-GAG degradation GABA B RECEPTOR ACTIVATION%REACTOME%R-RNO-977444.1 GABA B receptor activation GLYCEROPHOSPHOLIPID CATABOLISM%REACTOME DATABASE ID RELEASE 66%10146195 Glycerophospholipid catabolism PI3K AKT SIGNALING%REACTOME%R-RNO-1257604.1 PI3K AKT Signaling SUMOYLATION OF TRANSCRIPTION FACTORS%REACTOME%R-RNO-3232118.1 SUMOylation of transcription factors M PHASE%REACTOME%R-RNO-68886.1 M Phase ACTIVATION OF BID AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%R-RNO-75108.1 Activation of BID and translocation to mitochondria FGFR1C AND KLOTHO LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 66%10145295 FGFR1c and Klotho ligand binding and activation INTRAFLAGELLAR TRANSPORT%REACTOME%R-RNO-5620924.1 Intraflagellar transport BETA OXIDATION OF PALMITOYL-COA TO MYRISTOYL-COA%REACTOME DATABASE ID RELEASE 66%10144934 Beta oxidation of palmitoyl-CoA to myristoyl-CoA SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE%REACTOME DATABASE ID RELEASE 66%10145902 Synthesis of PIPs at the early endosome membrane RNA POLYMERASE II TRANSCRIPTION ELONGATION%REACTOME%R-RNO-75955.1 RNA Polymerase II Transcription Elongation TOLL LIKE RECEPTOR 5 (TLR5) CASCADE%REACTOME DATABASE ID RELEASE 66%10145157 Toll Like Receptor 5 (TLR5) Cascade GLUCOCORTICOID BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 66%10145323 Glucocorticoid biosynthesis REACTIONS SPECIFIC TO THE COMPLEX N-GLYCAN SYNTHESIS PATHWAY%REACTOME DATABASE ID RELEASE 66%10145779 Reactions specific to the complex N-glycan synthesis pathway SIGNALING BY INTERLEUKINS%REACTOME DATABASE ID RELEASE 66%10145163 Signaling by Interleukins DETOXIFICATION OF REACTIVE OXYGEN SPECIES%REACTOME%R-RNO-3299685.1 Detoxification of Reactive Oxygen Species PLASMA LIPOPROTEIN CLEARANCE%REACTOME%R-RNO-8964043.1 Plasma lipoprotein clearance PEROXISOMAL LIPID METABOLISM%REACTOME%R-RNO-390918.1 Peroxisomal lipid metabolism GAP JUNCTION ASSEMBLY%REACTOME%R-RNO-190861.1 Gap junction assembly DNA DAMAGE RECOGNITION IN GG-NER%REACTOME DATABASE ID RELEASE 66%10146144 DNA Damage Recognition in GG-NER MITOTIC METAPHASE AND ANAPHASE%REACTOME DATABASE ID RELEASE 66%10145109 Mitotic Metaphase and Anaphase POST NMDA RECEPTOR ACTIVATION EVENTS%REACTOME%R-RNO-438064.1 Post NMDA receptor activation events MAP KINASE ACTIVATION%REACTOME DATABASE ID RELEASE 66%10145160 MAP kinase activation NUCLEOBASE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 66%10144842 Nucleobase biosynthesis MITOCHONDRIAL TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 66%10145689 Mitochondrial tRNA aminoacylation PI3K AKT ACTIVATION%REACTOME DATABASE ID RELEASE 66%10145352 PI3K AKT activation PTK6 REGULATES PROTEINS INVOLVED IN RNA PROCESSING%REACTOME DATABASE ID RELEASE 66%10146207 PTK6 Regulates Proteins Involved in RNA Processing CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE%REACTOME%R-RNO-204998.1 Cell death signalling via NRAGE, NRIF and NADE SELENOAMINO ACID METABOLISM%REACTOME%R-RNO-2408522.1 Selenoamino acid metabolism CELL CYCLE CHECKPOINTS%REACTOME DATABASE ID RELEASE 66%10144741 Cell Cycle Checkpoints NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC)%REACTOME%R-RNO-975957.1 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) INTERLEUKIN-18 SIGNALING%REACTOME%R-RNO-9012546.1 Interleukin-18 signaling FRS-MEDIATED FGFR2 SIGNALING%REACTOME DATABASE ID RELEASE 66%10146103 FRS-mediated FGFR2 signaling BASE-EXCISION REPAIR, AP SITE FORMATION%REACTOME%R-RNO-73929.1 Base-Excision Repair, AP Site Formation RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER%REACTOME DATABASE ID RELEASE 66%10144947 RNA Polymerase III Transcription Initiation From Type 2 Promoter CYP2E1 REACTIONS%REACTOME%R-RNO-211999.1 CYP2E1 reactions TRANSLATION INITIATION COMPLEX FORMATION%REACTOME DATABASE ID RELEASE 66%10145076 Translation initiation complex formation UNBLOCKING OF NMDA RECEPTORS, GLUTAMATE BINDING AND ACTIVATION%REACTOME%R-RNO-438066.1 Unblocking of NMDA receptors, glutamate binding and activation CAMK IV-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%R-RNO-111932.1 CaMK IV-mediated phosphorylation of CREB LYSOSPHINGOLIPID AND LPA RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145608 Lysosphingolipid and LPA receptors METABOLISM OF INGESTED SEMET, SEC, MESEC INTO H2SE%REACTOME%R-RNO-2408508.1 Metabolism of ingested SeMet, Sec, MeSec into H2Se GLYCOSAMINOGLYCAN METABOLISM%REACTOME%R-RNO-1630316.1 Glycosaminoglycan metabolism RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 66%10144983 Resolution of AP sites via the multiple-nucleotide patch replacement pathway IGF1R SIGNALING CASCADE%REACTOME%R-RNO-2428924.1 IGF1R signaling cascade CELLULAR RESPONSES TO EXTERNAL STIMULI%REACTOME%R-RNO-8953897.1 Cellular responses to external stimuli CHYLOMICRON CLEARANCE%REACTOME%R-RNO-8964026.1 Chylomicron clearance HIGHLY SODIUM PERMEABLE ACETYLCHOLINE NICOTINIC RECEPTORS%REACTOME%R-RNO-629587.1 Highly sodium permeable acetylcholine nicotinic receptors NEGATIVE REGULATION OF MAPK PATHWAY%REACTOME%R-RNO-5675221.1 Negative regulation of MAPK pathway SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE%REACTOME DATABASE ID RELEASE 66%10145899 Synthesis of PIPs at the late endosome membrane ACETYLCHOLINE REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 66%10145585 Acetylcholine regulates insulin secretion RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS%REACTOME%R-RNO-674695.1 RNA Polymerase II Pre-transcription Events REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA)%REACTOME DATABASE ID RELEASE 66%10145590 Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) CONJUGATION OF SALICYLATE WITH GLYCINE%REACTOME%R-RNO-177128.1 Conjugation of salicylate with glycine CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY%REACTOME DATABASE ID RELEASE 66%10145212 Cyclin A:Cdk2-associated events at S phase entry NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 66%10145513 Nuclear Receptor transcription pathway AURKA ACTIVATION BY TPX2%REACTOME%R-RNO-8854518.1 AURKA Activation by TPX2 FATTY ACIDS%REACTOME%R-RNO-211935.1 Fatty acids MITOTIC PROPHASE%REACTOME DATABASE ID RELEASE 66%10145525 Mitotic Prophase THE RETINOID CYCLE IN CONES (DAYLIGHT VISION)%REACTOME DATABASE ID RELEASE 66%10145969 The retinoid cycle in cones (daylight vision) TERMINATION OF O-GLYCAN BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 66%10145784 Termination of O-glycan biosynthesis GLYCOGEN METABOLISM%REACTOME DATABASE ID RELEASE 66%10144770 Glycogen metabolism INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES%REACTOME%R-RNO-499943.1 Interconversion of nucleotide di- and triphosphates N-GLYCAN ANTENNAE ELONGATION%REACTOME DATABASE ID RELEASE 66%10145781 N-Glycan antennae elongation O-LINKED GLYCOSYLATION%REACTOME%R-RNO-5173105.1 O-linked glycosylation DNA REPLICATION INITIATION%REACTOME DATABASE ID RELEASE 66%10144718 DNA replication initiation PURINE SALVAGE%REACTOME DATABASE ID RELEASE 66%10144873 Purine salvage G-PROTEIN BETA:GAMMA SIGNALLING%REACTOME%R-RNO-397795.1 G-protein beta:gamma signalling ALTERNATIVE COMPLEMENT ACTIVATION%REACTOME DATABASE ID RELEASE 66%10145211 Alternative complement activation SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP)%REACTOME DATABASE ID RELEASE 66%10145264 Senescence-Associated Secretory Phenotype (SASP) SIGNALING BY INSULIN RECEPTOR%REACTOME%R-RNO-74752.1 Signaling by Insulin receptor SIGNALING BY NODAL%REACTOME%R-RNO-1181150.1 Signaling by NODAL PI3K EVENTS IN ERBB2 SIGNALING%REACTOME DATABASE ID RELEASE 66%10145823 PI3K events in ERBB2 signaling U12 DEPENDENT SPLICING%REACTOME%R-RNO-72165.1 U12 Dependent Splicing RHO GTPASES ACTIVATE PKNS%REACTOME%R-RNO-5625740.1 RHO GTPases activate PKNs C6 DEAMINATION OF ADENOSINE%REACTOME%R-RNO-75102.1 C6 deamination of adenosine SERINE BIOSYNTHESIS%REACTOME%R-RNO-977347.1 Serine biosynthesis NEGATIVE REGULATION OF THE PI3K AKT NETWORK%REACTOME%R-RNO-199418.1 Negative regulation of the PI3K AKT network METABOLISM OF FOLATE AND PTERINES%REACTOME%R-RNO-196757.1 Metabolism of folate and pterines ACTIVATION OF C3 AND C5%REACTOME%R-RNO-174577.1 Activation of C3 and C5 SHC-MEDIATED CASCADE:FGFR3%REACTOME%R-RNO-5654704.1 SHC-mediated cascade:FGFR3 BIOLOGICAL OXIDATIONS%REACTOME%R-RNO-211859.1 Biological oxidations NONCANONICAL ACTIVATION OF NOTCH3%REACTOME%R-RNO-9017802.1 Noncanonical activation of NOTCH3 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION)%REACTOME%R-RNO-2453902.1 The canonical retinoid cycle in rods (twilight vision) REGULATION OF TNFR1 SIGNALING%REACTOME DATABASE ID RELEASE 66%10146056 Regulation of TNFR1 signaling RNA POLYMERASE II PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 66%10144902 RNA Polymerase II Promoter Escape SUMOYLATION OF DNA METHYLATION PROTEINS%REACTOME%R-RNO-4655427.1 SUMOylation of DNA methylation proteins RUNX1 REGULATES ESTROGEN RECEPTOR MEDIATED TRANSCRIPTION%REACTOME DATABASE ID RELEASE 66%10146262 RUNX1 regulates estrogen receptor mediated transcription THREONINE CATABOLISM%REACTOME DATABASE ID RELEASE 66%10146296 Threonine catabolism METABOLISM OF RNA%REACTOME DATABASE ID RELEASE 66%10144827 Metabolism of RNA SYNTHESIS OF DOLICHYL-PHOSPHATE MANNOSE%REACTOME DATABASE ID RELEASE 66%10145103 Synthesis of dolichyl-phosphate mannose RNA POLYMERASE III TRANSCRIPTION INITIATION%REACTOME%R-RNO-76046.1 RNA Polymerase III Transcription Initiation ADENOSINE P1 RECEPTORS%REACTOME%R-RNO-417973.1 Adenosine P1 receptors WAX BIOSYNTHESIS%REACTOME%R-RNO-8848584.1 Wax biosynthesis ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 66%10145451 Acetylcholine Neurotransmitter Release Cycle TRAIL SIGNALING%REACTOME%R-RNO-75158.1 TRAIL signaling DIGESTION%REACTOME DATABASE ID RELEASE 66%10145278 Digestion CELLULAR SENESCENCE%REACTOME%R-RNO-2559583.1 Cellular Senescence G ALPHA (S) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 66%10145517 G alpha (s) signalling events TNFR1-MEDIATED CERAMIDE PRODUCTION%REACTOME DATABASE ID RELEASE 66%10146089 TNFR1-mediated ceramide production SIGNALING BY RETINOIC ACID%REACTOME DATABASE ID RELEASE 66%10145381 Signaling by Retinoic Acid DIMERIZATION OF PROCASPASE-8%REACTOME%R-RNO-69416.1 Dimerization of procaspase-8 REGULATION OF GAP JUNCTION ACTIVITY%REACTOME DATABASE ID RELEASE 66%10145308 Regulation of gap junction activity PROLONGED ERK ACTIVATION EVENTS%REACTOME DATABASE ID RELEASE 66%10145181 Prolonged ERK activation events RELEASE OF APOPTOTIC FACTORS FROM THE MITOCHONDRIA%REACTOME DATABASE ID RELEASE 66%10145018 Release of apoptotic factors from the mitochondria SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE%REACTOME%R-RNO-1660499.1 Synthesis of PIPs at the plasma membrane TRANSPORT AND SYNTHESIS OF PAPS%REACTOME%R-RNO-174362.1 Transport and synthesis of PAPS DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING%REACTOME DATABASE ID RELEASE 66%10145207 Downregulation of TGF-beta receptor signaling SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI)%REACTOME%R-RNO-162710.1 Synthesis of glycosylphosphatidylinositol (GPI) INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS%REACTOME%R-RNO-997272.1 Inhibition of voltage gated Ca2+ channels via Gbeta gamma subunits PROTON-COUPLED NEUTRAL AMINO ACID TRANSPORTERS%REACTOME DATABASE ID RELEASE 66%10145510 Proton-coupled neutral amino acid transporters ERYTHROPOIETIN ACTIVATES PHOSPHOINOSITIDE-3-KINASE (PI3K)%REACTOME DATABASE ID RELEASE 66%10146294 Erythropoietin activates Phosphoinositide-3-kinase (PI3K) METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS%REACTOME DATABASE ID RELEASE 66%10145925 Metabolism of Angiotensinogen to Angiotensins ION CHANNEL TRANSPORT%REACTOME DATABASE ID RELEASE 66%10145600 Ion channel transport CREB3 FACTORS ACTIVATE GENES%REACTOME DATABASE ID RELEASE 66%10146248 CREB3 factors activate genes ORC1 REMOVAL FROM CHROMATIN%REACTOME%R-RNO-68949.1 Orc1 removal from chromatin SIGNALING BY FGFR2%REACTOME DATABASE ID RELEASE 66%10145256 Signaling by FGFR2 AMINE OXIDASE REACTIONS%REACTOME DATABASE ID RELEASE 66%10145056 Amine Oxidase reactions TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION%REACTOME%R-RNO-948021.1 Transport to the Golgi and subsequent modification L1CAM INTERACTIONS%REACTOME DATABASE ID RELEASE 66%10144965 L1CAM interactions PROLACTIN RECEPTOR SIGNALING%REACTOME DATABASE ID RELEASE 66%10145783 Prolactin receptor signaling ACETYLATION%REACTOME DATABASE ID RELEASE 66%10145083 Acetylation CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII%REACTOME DATABASE ID RELEASE 66%10145658 CREB phosphorylation through the activation of CaMKII FORMATION OF XYLULOSE-5-PHOSPHATE%REACTOME DATABASE ID RELEASE 66%10146116 Formation of xylulose-5-phosphate BETA DEFENSINS%REACTOME DATABASE ID RELEASE 66%10145858 Beta defensins GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY%REACTOME%R-RNO-399721.1 Glutamate binding, activation of AMPA receptors and synaptic plasticity STRIATED MUSCLE CONTRACTION%REACTOME%R-RNO-390522.1 Striated Muscle Contraction ABC TRANSPORTERS IN LIPID HOMEOSTASIS%REACTOME DATABASE ID RELEASE 66%10145461 ABC transporters in lipid homeostasis RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF MYELOID CELLS%REACTOME DATABASE ID RELEASE 66%10146266 RUNX1 regulates transcription of genes involved in differentiation of myeloid cells ESR-MEDIATED SIGNALING%REACTOME DATABASE ID RELEASE 66%10145830 ESR-mediated signaling G ALPHA (Q) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 66%10145036 G alpha (q) signalling events PI3K EVENTS IN ERBB4 SIGNALING%REACTOME%R-RNO-1250342.1 PI3K events in ERBB4 signaling CGMP EFFECTS%REACTOME%R-RNO-418457.1 cGMP effects INTERACTION BETWEEN PHLDA1 AND AURKA%REACTOME DATABASE ID RELEASE 66%10146219 Interaction between PHLDA1 and AURKA G-PROTEIN MEDIATED EVENTS%REACTOME%R-RNO-112040.1 G-protein mediated events ERBB2 REGULATES CELL MOTILITY%REACTOME DATABASE ID RELEASE 66%10146156 ERBB2 Regulates Cell Motility S PHASE%REACTOME%R-RNO-69242.1 S Phase IL-6-TYPE CYTOKINE RECEPTOR LIGAND INTERACTIONS%REACTOME DATABASE ID RELEASE 66%10145682 IL-6-type cytokine receptor ligand interactions VESICLE-MEDIATED TRANSPORT%REACTOME DATABASE ID RELEASE 66%10145300 Vesicle-mediated transport CONJUGATION OF PHENYLACETATE WITH GLUTAMINE%REACTOME DATABASE ID RELEASE 66%10145246 Conjugation of phenylacetate with glutamine SIGNALING BY FGFR1%REACTOME%R-RNO-5654736.1 Signaling by FGFR1 RNA POLYMERASE I CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 66%10144884 RNA Polymerase I Chain Elongation INTERLEUKIN-17 SIGNALING%REACTOME%R-RNO-448424.1 Interleukin-17 signaling HDMS DEMETHYLATE HISTONES%REACTOME DATABASE ID RELEASE 66%10145998 HDMs demethylate histones RNA POLYMERASE I TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 66%10144850 RNA Polymerase I Transcription Initiation SCAVENGING OF HEME FROM PLASMA%REACTOME%R-RNO-2168880.1 Scavenging of heme from plasma MAP3K8 (TPL2)-DEPENDENT MAPK1 3 ACTIVATION%REACTOME DATABASE ID RELEASE 66%10145702 MAP3K8 (TPL2)-dependent MAPK1 3 activation SYNTHESIS OF 5-EICOSATETRAENOIC ACIDS%REACTOME%R-RNO-2142688.1 Synthesis of 5-eicosatetraenoic acids MYOGENESIS%REACTOME%R-RNO-525793.1 Myogenesis CHONDROITIN SULFATE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 66%10145919 Chondroitin sulfate biosynthesis SIGNALING BY LEPTIN%REACTOME DATABASE ID RELEASE 66%10145709 Signaling by Leptin ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1%REACTOME DATABASE ID RELEASE 66%10145597 ADP signalling through P2Y purinoceptor 1 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE%REACTOME%R-RNO-2559586.1 DNA Damage Telomere Stress Induced Senescence FATTY ACYL-COA BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 66%10144901 Fatty acyl-CoA biosynthesis P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME%R-RNO-69580.1 p53-Dependent G1 S DNA damage checkpoint RSK ACTIVATION%REACTOME DATABASE ID RELEASE 66%10145660 RSK activation PROCESSING OF CAPPED INTRONLESS PRE-MRNA%REACTOME%R-RNO-75067.1 Processing of Capped Intronless Pre-mRNA DUAL INCISION IN GG-NER%REACTOME DATABASE ID RELEASE 66%10146140 Dual Incision in GG-NER CONDENSATION OF PROPHASE CHROMOSOMES%REACTOME DATABASE ID RELEASE 66%10145955 Condensation of Prophase Chromosomes REGULATION OF TP53 ACTIVITY%REACTOME%R-RNO-5633007.1 Regulation of TP53 Activity MICROTUBULE-DEPENDENT TRAFFICKING OF CONNEXONS FROM GOLGI TO THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 66%10145301 Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane ER TO GOLGI ANTEROGRADE TRANSPORT%REACTOME%R-RNO-199977.1 ER to Golgi Anterograde Transport IRON UPTAKE AND TRANSPORT%REACTOME DATABASE ID RELEASE 66%10145283 Iron uptake and transport CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION%REACTOME DATABASE ID RELEASE 66%10145415 Class I MHC mediated antigen processing & presentation POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%R-RNO-622327.1 Postsynaptic nicotinic acetylcholine receptors INTERLEUKIN-15 SIGNALING%REACTOME%R-RNO-8983432.1 Interleukin-15 signaling CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE%REACTOME%R-RNO-176407.1 Conversion from APC C:Cdc20 to APC C:Cdh1 in late anaphase ACTIVATED NTRK2 SIGNALS THROUGH FYN%REACTOME DATABASE ID RELEASE 66%10146323 Activated NTRK2 signals through FYN MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF SATURATED FATTY ACIDS%REACTOME%R-RNO-77286.1 mitochondrial fatty acid beta-oxidation of saturated fatty acids MET ACTIVATES RAP1 AND RAC1%REACTOME DATABASE ID RELEASE 66%10146252 MET activates RAP1 and RAC1 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION%REACTOME%R-RNO-156827.1 L13a-mediated translational silencing of Ceruloplasmin expression HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME%R-RNO-5693579.1 Homologous DNA Pairing and Strand Exchange P75NTR SIGNALS VIA NF-KB%REACTOME%R-RNO-193639.1 p75NTR signals via NF-kB CELL-CELL COMMUNICATION%REACTOME DATABASE ID RELEASE 66%10145431 Cell-Cell communication RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASES%REACTOME DATABASE ID RELEASE 66%10145543 Receptor-type tyrosine-protein phosphatases SULFIDE OXIDATION TO SULFATE%REACTOME DATABASE ID RELEASE 66%10145889 Sulfide oxidation to sulfate SIGNALING BY EGFR%REACTOME DATABASE ID RELEASE 66%10144957 Signaling by EGFR INVADOPODIA FORMATION%REACTOME DATABASE ID RELEASE 66%10146271 Invadopodia formation P53-DEPENDENT G1 DNA DAMAGE RESPONSE%REACTOME%R-RNO-69563.1 p53-Dependent G1 DNA Damage Response METAL SEQUESTRATION BY ANTIMICROBIAL PROTEINS%REACTOME DATABASE ID RELEASE 66%10145804 Metal sequestration by antimicrobial proteins SUMOYLATION OF IMMUNE RESPONSE PROTEINS%REACTOME%R-RNO-4755510.1 SUMOylation of immune response proteins LYSINE CATABOLISM%REACTOME%R-RNO-71064.1 Lysine catabolism ARL13B-MEDIATED CILIARY TRAFFICKING OF INPP5E%REACTOME DATABASE ID RELEASE 66%10146085 ARL13B-mediated ciliary trafficking of INPP5E TRANSPORT OF FATTY ACIDS%REACTOME%R-RNO-804914.1 Transport of fatty acids COPI-DEPENDENT GOLGI-TO-ER RETROGRADE TRAFFIC%REACTOME%R-RNO-6811434.1 COPI-dependent Golgi-to-ER retrograde traffic METABOLISM OF PROTEINS%REACTOME DATABASE ID RELEASE 66%10144825 Metabolism of proteins IRF3-MEDIATED INDUCTION OF TYPE I IFN%REACTOME DATABASE ID RELEASE 66%10145930 IRF3-mediated induction of type I IFN REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION%REACTOME%R-RNO-2565942.1 Regulation of PLK1 Activity at G2 M Transition INTERLEUKIN-33 SIGNALING%REACTOME%R-RNO-9014843.1 Interleukin-33 signaling MHC CLASS II ANTIGEN PRESENTATION%REACTOME DATABASE ID RELEASE 66%10145936 MHC class II antigen presentation DNA REPLICATION%REACTOME%R-RNO-69306.1 DNA Replication ARYL HYDROCARBON RECEPTOR SIGNALLING%REACTOME DATABASE ID RELEASE 66%10146264 Aryl hydrocarbon receptor signalling ISG15 ANTIVIRAL MECHANISM%REACTOME DATABASE ID RELEASE 66%10145800 ISG15 antiviral mechanism GENERIC TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 66%10144749 Generic Transcription Pathway ACYL CHAIN REMODELING OF CL%REACTOME%R-RNO-1482798.1 Acyl chain remodeling of CL VOLTAGE GATED POTASSIUM CHANNELS%REACTOME DATABASE ID RELEASE 66%10145837 Voltage gated Potassium channels ADHERENS JUNCTIONS INTERACTIONS%REACTOME DATABASE ID RELEASE 66%10145606 Adherens junctions interactions BETA-OXIDATION OF PRISTANOYL-COA%REACTOME%R-RNO-389887.1 Beta-oxidation of pristanoyl-CoA SEMA4D IN SEMAPHORIN SIGNALING%REACTOME%R-RNO-400685.1 Sema4D in semaphorin signaling TRANSCRIPTIONAL REGULATION BY E2F6%REACTOME%R-RNO-8953750.1 Transcriptional Regulation by E2F6 SUMOYLATION OF DNA DAMAGE RESPONSE AND REPAIR PROTEINS%REACTOME%R-RNO-3108214.1 SUMOylation of DNA damage response and repair proteins ERK1 ERK2 PATHWAY%REACTOME DATABASE ID RELEASE 66%10144961 ERK1 ERK2 pathway TOLL LIKE RECEPTOR 9 (TLR9) CASCADE%REACTOME DATABASE ID RELEASE 66%10145153 Toll Like Receptor 9 (TLR9) Cascade GLUCAGON SIGNALING IN METABOLIC REGULATION%REACTOME DATABASE ID RELEASE 66%10145003 Glucagon signaling in metabolic regulation ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION%REACTOME DATABASE ID RELEASE 66%10145786 Antigen processing: Ubiquitination & Proteasome degradation GAP JUNCTION TRAFFICKING%REACTOME%R-RNO-190828.1 Gap junction trafficking REGULATION OF PTEN STABILITY AND ACTIVITY%REACTOME DATABASE ID RELEASE 66%10146185 Regulation of PTEN stability and activity EXTRINSIC PATHWAY OF FIBRIN CLOT FORMATION%REACTOME DATABASE ID RELEASE 66%10145054 Extrinsic Pathway of Fibrin Clot Formation MITOCHONDRIAL TRANSLATION ELONGATION%REACTOME DATABASE ID RELEASE 66%10146063 Mitochondrial translation elongation TRANSFER OF LPS FROM LBP CARRIER TO CD14%REACTOME%R-RNO-166020.1 Transfer of LPS from LBP carrier to CD14 ENOS ACTIVATION AND REGULATION%REACTOME%R-RNO-203765.1 eNOS activation and regulation G2 M TRANSITION%REACTOME%R-RNO-69275.1 G2 M Transition SYNTHESIS OF GDP-MANNOSE%REACTOME DATABASE ID RELEASE 66%10145672 Synthesis of GDP-mannose PI-3K CASCADE:FGFR3%REACTOME DATABASE ID RELEASE 66%10145257 PI-3K cascade:FGFR3 PAOS OXIDISE POLYAMINES TO AMINES%REACTOME DATABASE ID RELEASE 66%10145060 PAOs oxidise polyamines to amines DOWNREGULATION OF ERBB4 SIGNALING%REACTOME DATABASE ID RELEASE 66%10145828 Downregulation of ERBB4 signaling REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION%REACTOME%R-RNO-2029482.1 Regulation of actin dynamics for phagocytic cup formation TERMINAL PATHWAY OF COMPLEMENT%REACTOME DATABASE ID RELEASE 66%10145210 Terminal pathway of complement REGULATION OF RUNX1 EXPRESSION AND ACTIVITY%REACTOME%R-RNO-8934593.1 Regulation of RUNX1 Expression and Activity INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%R-RNO-2514859.1 Inactivation, recovery and regulation of the phototransduction cascade GENERATION OF SECOND MESSENGER MOLECULES%REACTOME DATABASE ID RELEASE 66%10145400 Generation of second messenger molecules MITOCHONDRIAL TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 66%10145119 Mitochondrial transcription termination CLEAVAGE OF THE DAMAGED PYRIMIDINE%REACTOME%R-RNO-110329.1 Cleavage of the damaged pyrimidine INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME DATABASE ID RELEASE 66%10145016 Intrinsic Pathway for Apoptosis PHASE 3 - RAPID REPOLARISATION%REACTOME%R-RNO-5576890.1 Phase 3 - rapid repolarisation TRANSLESION SYNTHESIS BY POLH%REACTOME%R-RNO-110320.1 Translesion Synthesis by POLH PLATELET CALCIUM HOMEOSTASIS%REACTOME%R-RNO-418360.1 Platelet calcium homeostasis NUCLEAR ENVELOPE REASSEMBLY%REACTOME%R-RNO-2995410.1 Nuclear Envelope Reassembly DAG AND IP3 SIGNALING%REACTOME%R-RNO-1489509.1 DAG and IP3 signaling ION INFLUX EFFLUX AT HOST-PATHOGEN INTERFACE%REACTOME%R-RNO-6803544.1 Ion influx efflux at host-pathogen interface GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER%REACTOME DATABASE ID RELEASE 66%10146143 Gap-filling DNA repair synthesis and ligation in GG-NER PYRIMIDINE CATABOLISM%REACTOME%R-RNO-73621.1 Pyrimidine catabolism GLYCOLYSIS%REACTOME DATABASE ID RELEASE 66%10144768 Glycolysis MOLECULES ASSOCIATED WITH ELASTIC FIBRES%REACTOME DATABASE ID RELEASE 66%10145882 Molecules associated with elastic fibres OXIDATIVE DEMETHYLATION OF DNA%REACTOME DATABASE ID RELEASE 66%10146048 Oxidative demethylation of DNA TRANSPORT OF CONNEXONS TO THE PLASMA MEMBRANE%REACTOME%R-RNO-190872.1 Transport of connexons to the plasma membrane RRNA PROCESSING%REACTOME DATABASE ID RELEASE 66%10146163 rRNA processing AGMATINE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 66%10145466 Agmatine biosynthesis MUSCARINIC ACETYLCHOLINE RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145559 Muscarinic acetylcholine receptors ACTIVATED NTRK2 SIGNALS THROUGH PLCG1%REACTOME%R-RNO-9026527.1 Activated NTRK2 signals through PLCG1 KETONE BODY METABOLISM%REACTOME DATABASE ID RELEASE 66%10144854 Ketone body metabolism TYPE II NA+ PI COTRANSPORTERS%REACTOME DATABASE ID RELEASE 66%10145628 Type II Na+ Pi cotransporters TRAF3-DEPENDENT IRF ACTIVATION PATHWAY%REACTOME DATABASE ID RELEASE 66%10145795 TRAF3-dependent IRF activation pathway ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX%REACTOME%R-RNO-68867.1 Assembly of the pre-replicative complex SYNTHESIS OF PC%REACTOME DATABASE ID RELEASE 66%10145452 Synthesis of PC HYALURONAN UPTAKE AND DEGRADATION%REACTOME%R-RNO-2160916.1 Hyaluronan uptake and degradation SIGNALING BY NOTCH1%REACTOME DATABASE ID RELEASE 66%10145913 Signaling by NOTCH1 PASSIVE TRANSPORT BY AQUAPORINS%REACTOME DATABASE ID RELEASE 66%10145707 Passive transport by Aquaporins NCAM1 INTERACTIONS%REACTOME DATABASE ID RELEASE 66%10145505 NCAM1 interactions SIALIC ACID METABOLISM%REACTOME DATABASE ID RELEASE 66%10145633 Sialic acid metabolism G1 S DNA DAMAGE CHECKPOINTS%REACTOME DATABASE ID RELEASE 66%10144740 G1 S DNA Damage Checkpoints SODIUM-COUPLED PHOSPHATE COTRANSPORTERS%REACTOME DATABASE ID RELEASE 66%10145627 Sodium-coupled phosphate cotransporters REGULATION OF COMMISSURAL AXON PATHFINDING BY SLIT AND ROBO%REACTOME DATABASE ID RELEASE 66%10145632 Regulation of commissural axon pathfinding by SLIT and ROBO REGULATION OF PTEN LOCALIZATION%REACTOME%R-RNO-8948747.1 Regulation of PTEN localization PHASE II - CONJUGATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 66%10144773 Phase II - Conjugation of compounds TRANSFERRIN ENDOCYTOSIS AND RECYCLING%REACTOME%R-RNO-917977.1 Transferrin endocytosis and recycling NECTIN NECL TRANS HETERODIMERIZATION%REACTOME DATABASE ID RELEASE 66%10145613 Nectin Necl trans heterodimerization REGULATION OF FZD BY UBIQUITINATION%REACTOME DATABASE ID RELEASE 66%10146037 Regulation of FZD by ubiquitination FGFR3B LIGAND BINDING AND ACTIVATION%REACTOME%R-RNO-190371.1 FGFR3b ligand binding and activation ION HOMEOSTASIS%REACTOME DATABASE ID RELEASE 66%10145041 Ion homeostasis DEVELOPMENTAL BIOLOGY%REACTOME DATABASE ID RELEASE 66%10144967 Developmental Biology GPCR DOWNSTREAM SIGNALLING%REACTOME DATABASE ID RELEASE 66%10144869 GPCR downstream signalling PHOSPHATE BOND HYDROLYSIS BY NTPDASE PROTEINS%REACTOME DATABASE ID RELEASE 66%10146210 Phosphate bond hydrolysis by NTPDase proteins ANTAGONISM OF ACTIVIN BY FOLLISTATIN%REACTOME%R-RNO-2473224.1 Antagonism of Activin by Follistatin PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR%REACTOME%R-RNO-392851.1 Prostacyclin signalling through prostacyclin receptor CHOLINE CATABOLISM%REACTOME%R-RNO-6798163.1 Choline catabolism MULTIFUNCTIONAL ANION EXCHANGERS%REACTOME DATABASE ID RELEASE 66%10145626 Multifunctional anion exchangers TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 66%10144823 tRNA Aminoacylation OLFACTORY SIGNALING PATHWAY%REACTOME%R-RNO-381753.1 Olfactory Signaling Pathway VLDLR INTERNALISATION AND DEGRADATION%REACTOME%R-RNO-8866427.1 VLDLR internalisation and degradation BETA OXIDATION OF HEXANOYL-COA TO BUTANOYL-COA%REACTOME%R-RNO-77350.1 Beta oxidation of hexanoyl-CoA to butanoyl-CoA FANCONI ANEMIA PATHWAY%REACTOME%R-RNO-6783310.1 Fanconi Anemia Pathway REGULATION OF TP53 ACTIVITY THROUGH ASSOCIATION WITH CO-FACTORS%REACTOME%R-RNO-6804759.1 Regulation of TP53 Activity through Association with Co-factors CLEC7A (DECTIN-1) INDUCES NFAT ACTIVATION%REACTOME%R-RNO-5607763.1 CLEC7A (Dectin-1) induces NFAT activation GP1B-IX-V ACTIVATION SIGNALLING%REACTOME DATABASE ID RELEASE 66%10145640 GP1b-IX-V activation signalling CATION-COUPLED CHLORIDE COTRANSPORTERS%REACTOME DATABASE ID RELEASE 66%10145620 Cation-coupled Chloride cotransporters FGFRL1 MODULATION OF FGFR1 SIGNALING%REACTOME%R-RNO-5658623.1 FGFRL1 modulation of FGFR1 signaling APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS%REACTOME%R-RNO-111465.1 Apoptotic cleavage of cellular proteins MICRORNA (MIRNA) BIOGENESIS%REACTOME%R-RNO-203927.1 MicroRNA (miRNA) biogenesis STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES%REACTOME%R-RNO-1834941.1 STING mediated induction of host immune responses MEIOTIC RECOMBINATION%REACTOME%R-RNO-912446.1 Meiotic recombination RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF KERATINOCYTES%REACTOME DATABASE ID RELEASE 66%10146265 RUNX1 regulates transcription of genes involved in differentiation of keratinocytes MITOCHONDRIAL PROTEIN IMPORT%REACTOME DATABASE ID RELEASE 66%10146287 Mitochondrial protein import ENZYMATIC DEGRADATION OF DOPAMINE BY MONOAMINE OXIDASE%REACTOME DATABASE ID RELEASE 66%10145518 Enzymatic degradation of Dopamine by monoamine oxidase G ALPHA (Z) SIGNALLING EVENTS%REACTOME%R-RNO-418597.1 G alpha (z) signalling events SURFACTANT METABOLISM%REACTOME DATABASE ID RELEASE 66%10145605 Surfactant metabolism AUTODEGRADATION OF CDH1 BY CDH1:APC C%REACTOME DATABASE ID RELEASE 66%10145213 Autodegradation of Cdh1 by Cdh1:APC C GLYCOPROTEIN HORMONES%REACTOME DATABASE ID RELEASE 66%10145514 Glycoprotein hormones RRNA PROCESSING IN THE NUCLEUS AND CYTOSOL%REACTOME DATABASE ID RELEASE 66%10146162 rRNA processing in the nucleus and cytosol INITIATION OF NUCLEAR ENVELOPE REFORMATION%REACTOME DATABASE ID RELEASE 66%10145989 Initiation of Nuclear Envelope Reformation METABOLISM OF STEROIDS%REACTOME DATABASE ID RELEASE 66%10145088 Metabolism of steroids REGULATION OF GENE EXPRESSION IN BETA CELLS%REACTOME%R-RNO-210745.1 Regulation of gene expression in beta cells ACTIVATION OF BH3-ONLY PROTEINS%REACTOME DATABASE ID RELEASE 66%10145046 Activation of BH3-only proteins EXPRESSION AND PROCESSING OF NEUROTROPHINS%REACTOME%R-RNO-9036866.1 Expression and Processing of Neurotrophins G2 PHASE%REACTOME DATABASE ID RELEASE 66%10145274 G2 Phase CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION%REACTOME%R-RNO-109688.1 Cleavage of Growing Transcript in the Termination Region CA2+ PATHWAY%REACTOME DATABASE ID RELEASE 66%10145578 Ca2+ pathway VITAMIN E%REACTOME DATABASE ID RELEASE 66%10146249 Vitamin E INTRACELLULAR SIGNALING BY SECOND MESSENGERS%REACTOME DATABASE ID RELEASE 66%10144994 Intracellular signaling by second messengers RECEPTOR MEDIATED MITOPHAGY%REACTOME DATABASE ID RELEASE 66%10146273 Receptor Mediated Mitophagy SOS-MEDIATED SIGNALLING%REACTOME%R-RNO-112412.1 SOS-mediated signalling TCF DEPENDENT SIGNALING IN RESPONSE TO WNT%REACTOME%R-RNO-201681.1 TCF dependent signaling in response to WNT OTHER INTERLEUKIN SIGNALING%REACTOME%R-RNO-449836.1 Other interleukin signaling INTRA-GOLGI TRAFFIC%REACTOME DATABASE ID RELEASE 66%10146194 Intra-Golgi traffic GRB2 EVENTS IN ERBB2 SIGNALING%REACTOME DATABASE ID RELEASE 66%10145849 GRB2 events in ERBB2 signaling DAP12 INTERACTIONS%REACTOME%R-RNO-2172127.1 DAP12 interactions ORGANIC ANION TRANSPORT%REACTOME%R-RNO-561048.1 Organic anion transport TRYPTOPHAN CATABOLISM%REACTOME%R-RNO-71240.1 Tryptophan catabolism SYNTHESIS OF LIPOXINS (LX)%REACTOME DATABASE ID RELEASE 66%10145463 Synthesis of Lipoxins (LX) AXONAL GROWTH STIMULATION%REACTOME%R-RNO-209563.1 Axonal growth stimulation SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL%REACTOME%R-RNO-1855183.1 Synthesis of IP2, IP, and Ins in the cytosol RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 66%10144903 RNA Polymerase II Transcription Initiation And Promoter Clearance SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21%REACTOME DATABASE ID RELEASE 66%10145271 SCF(Skp2)-mediated degradation of p27 p21 GLYOXYLATE METABOLISM AND GLYCINE DEGRADATION%REACTOME%R-RNO-389661.1 Glyoxylate metabolism and glycine degradation ERYTHROPOIETIN ACTIVATES RAS%REACTOME DATABASE ID RELEASE 66%10146321 Erythropoietin activates RAS MITOCHONDRIAL UNCOUPLING PROTEINS%REACTOME DATABASE ID RELEASE 66%10145136 Mitochondrial Uncoupling Proteins INTERACTION BETWEEN L1 AND ANKYRINS%REACTOME DATABASE ID RELEASE 66%10145576 Interaction between L1 and Ankyrins REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX%REACTOME%R-RNO-204174.1 Regulation of pyruvate dehydrogenase (PDH) complex ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S%REACTOME%R-RNO-72662.1 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S SYNTHESIS OF DOLICHYL-PHOSPHATE%REACTOME DATABASE ID RELEASE 66%10145306 Synthesis of Dolichyl-phosphate KETONE BODY CATABOLISM%REACTOME%R-RNO-77108.1 Ketone body catabolism REDUCTION OF CYTOSOLIC CA++ LEVELS%REACTOME%R-RNO-418359.1 Reduction of cytosolic Ca++ levels TCR SIGNALING%REACTOME DATABASE ID RELEASE 66%10145376 TCR signaling SUMOYLATION%REACTOME%R-RNO-2990846.1 SUMOylation CALMODULIN INDUCED EVENTS%REACTOME DATABASE ID RELEASE 66%10144991 Calmodulin induced events ACTIVATION OF PKB%REACTOME DATABASE ID RELEASE 66%10144955 Activation of PKB MET ACTIVATES PTK2 SIGNALING%REACTOME DATABASE ID RELEASE 66%10146246 MET activates PTK2 signaling OPIOID SIGNALLING%REACTOME%R-RNO-111885.1 Opioid Signalling SIGNALING BY ERBB2%REACTOME%R-RNO-1227986.1 Signaling by ERBB2 PHASE 0 - RAPID DEPOLARISATION%REACTOME DATABASE ID RELEASE 66%10146067 Phase 0 - rapid depolarisation MISCELLANEOUS SUBSTRATES%REACTOME DATABASE ID RELEASE 66%10145442 Miscellaneous substrates HATS ACETYLATE HISTONES%REACTOME%R-RNO-3214847.1 HATs acetylate histones REGULATION OF IFNA SIGNALING%REACTOME%R-RNO-912694.1 Regulation of IFNA signaling ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES%REACTOME%R-RNO-1169410.1 Antiviral mechanism by IFN-stimulated genes SIGNALING BY NOTCH4%REACTOME DATABASE ID RELEASE 66%10146330 Signaling by NOTCH4 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM%REACTOME DATABASE ID RELEASE 66%10144804 Cobalamin (Cbl, vitamin B12) transport and metabolism ASSEMBLY OF ACTIVE LPL AND LIPC LIPASE COMPLEXES%REACTOME DATABASE ID RELEASE 66%10146149 Assembly of active LPL and LIPC lipase complexes SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX)%REACTOME%R-RNO-2162123.1 Synthesis of Prostaglandins (PG) and Thromboxanes (TX) INTERLEUKIN-38 SIGNALING%REACTOME DATABASE ID RELEASE 66%10146291 Interleukin-38 signaling AUF1 (HNRNP D0) BINDS AND DESTABILIZES MRNA%REACTOME DATABASE ID RELEASE 66%10145697 AUF1 (hnRNP D0) binds and destabilizes mRNA CYTOKINE SIGNALING IN IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 66%10145164 Cytokine Signaling in Immune system FORMATION OF A POOL OF FREE 40S SUBUNITS%REACTOME%R-RNO-72689.1 Formation of a pool of free 40S subunits LRR FLII-INTERACTING PROTEIN 1 (LRRFIP1) ACTIVATES TYPE I IFN PRODUCTION%REACTOME%R-RNO-3134973.1 LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production DISSOLUTION OF FIBRIN CLOT%REACTOME DATABASE ID RELEASE 66%10145082 Dissolution of Fibrin Clot RESOLUTION OF D-LOOP STRUCTURES THROUGH HOLLIDAY JUNCTION INTERMEDIATES%REACTOME%R-RNO-5693568.1 Resolution of D-loop Structures through Holliday Junction Intermediates RETINOID METABOLISM AND TRANSPORT%REACTOME DATABASE ID RELEASE 66%10145777 Retinoid metabolism and transport METABOLISM OF VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 66%10144806 Metabolism of vitamins and cofactors FIBRONECTIN MATRIX FORMATION%REACTOME%R-RNO-1566977.1 Fibronectin matrix formation RMTS METHYLATE HISTONE ARGININES%REACTOME%R-RNO-3214858.1 RMTs methylate histone arginines AMPK INHIBITS CHREBP TRANSCRIPTIONAL ACTIVATION ACTIVITY%REACTOME DATABASE ID RELEASE 66%10145123 AMPK inhibits chREBP transcriptional activation activity MAPK FAMILY SIGNALING CASCADES%REACTOME%R-RNO-5683057.1 MAPK family signaling cascades ACTIVATION OF NIMA KINASES NEK9, NEK6, NEK7%REACTOME%R-RNO-2980767.1 Activation of NIMA Kinases NEK9, NEK6, NEK7 CYSTEINE FORMATION FROM HOMOCYSTEINE%REACTOME%R-RNO-1614603.1 Cysteine formation from homocysteine NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION)%REACTOME%R-RNO-198725.1 Nuclear Events (kinase and transcription factor activation) PYRIMIDINE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 66%10144841 Pyrimidine biosynthesis ADAPTIVE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 66%10145356 Adaptive Immune System RAF-INDEPENDENT MAPK1 3 ACTIVATION%REACTOME DATABASE ID RELEASE 66%10144960 RAF-independent MAPK1 3 activation RNA POLYMERASE II TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 66%10144832 RNA Polymerase II Transcription Termination SYNTHESIS OF KETONE BODIES%REACTOME%R-RNO-77111.1 Synthesis of Ketone Bodies LACTOSE SYNTHESIS%REACTOME DATABASE ID RELEASE 66%10146097 Lactose synthesis DOWNSTREAM SIGNALING OF ACTIVATED FGFR4%REACTOME DATABASE ID RELEASE 66%10145261 Downstream signaling of activated FGFR4 VXPX CARGO-TARGETING TO CILIUM%REACTOME DATABASE ID RELEASE 66%10146083 VxPx cargo-targeting to cilium THE ROLE OF GTSE1 IN G2 M PROGRESSION AFTER G2 CHECKPOINT%REACTOME%R-RNO-8852276.1 The role of GTSE1 in G2 M progression after G2 checkpoint TWIK-RELATED SPINAL CORD K+ CHANNEL (TRESK)%REACTOME DATABASE ID RELEASE 66%10145846 TWIK-related spinal cord K+ channel (TRESK) NEUROTRANSMITTER RELEASE CYCLE%REACTOME%R-RNO-112310.1 Neurotransmitter release cycle FREE FATTY ACID RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145661 Free fatty acid receptors MAPK1 (ERK2) ACTIVATION%REACTOME DATABASE ID RELEASE 66%10144963 MAPK1 (ERK2) activation PROCESSING AND ACTIVATION OF SUMO%REACTOME%R-RNO-3215018.1 Processing and activation of SUMO RNA POLYMERASE II TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 66%10144905 RNA Polymerase II Transcription Initiation RUNX3 REGULATES WNT SIGNALING%REACTOME DATABASE ID RELEASE 66%10146277 RUNX3 regulates WNT signaling FORMATION OF EDITOSOMES BY ADAR PROTEINS%REACTOME%R-RNO-77042.1 Formation of editosomes by ADAR proteins ARACHIDONIC ACID METABOLISM%REACTOME%R-RNO-2142753.1 Arachidonic acid metabolism ION TRANSPORT BY P-TYPE ATPASES%REACTOME%R-RNO-936837.1 Ion transport by P-type ATPases PI-3K CASCADE:FGFR4%REACTOME%R-RNO-5654720.1 PI-3K cascade:FGFR4 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS%REACTOME DATABASE ID RELEASE 66%10144984 SLBP independent Processing of Histone Pre-mRNAs G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA%REACTOME%R-RNO-392451.1 G beta:gamma signalling through PI3Kgamma CLEC7A (DECTIN-1) SIGNALING%REACTOME%R-RNO-5607764.1 CLEC7A (Dectin-1) signaling CELL-EXTRACELLULAR MATRIX INTERACTIONS%REACTOME DATABASE ID RELEASE 66%10145642 Cell-extracellular matrix interactions SODIUM PROTON EXCHANGERS%REACTOME%R-RNO-425986.1 Sodium Proton exchangers INTERLEUKIN-7 SIGNALING%REACTOME%R-RNO-1266695.1 Interleukin-7 signaling ATTACHMENT OF GPI ANCHOR TO UPAR%REACTOME DATABASE ID RELEASE 66%10145107 Attachment of GPI anchor to uPAR ANTIGEN PROCESSING-CROSS PRESENTATION%REACTOME DATABASE ID RELEASE 66%10145813 Antigen processing-Cross presentation CALCITONIN-LIKE LIGAND RECEPTORS%REACTOME%R-RNO-419812.1 Calcitonin-like ligand receptors TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER%REACTOME%R-RNO-2173793.1 Transcriptional activity of SMAD2 SMAD3:SMAD4 heterotrimer P75NTR REGULATES AXONOGENESIS%REACTOME%R-RNO-193697.1 p75NTR regulates axonogenesis MET ACTIVATES PTPN11%REACTOME%R-RNO-8865999.1 MET activates PTPN11 RUNX1 AND FOXP3 CONTROL THE DEVELOPMENT OF REGULATORY T LYMPHOCYTES (TREGS)%REACTOME%R-RNO-8877330.1 RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) BILE ACID AND BILE SALT METABOLISM%REACTOME%R-RNO-194068.1 Bile acid and bile salt metabolism PREGNENOLONE BIOSYNTHESIS%REACTOME%R-RNO-196108.1 Pregnenolone biosynthesis CS DS DEGRADATION%REACTOME DATABASE ID RELEASE 66%10145885 CS DS degradation PI AND PC TRANSPORT BETWEEN ER AND GOLGI MEMBRANES%REACTOME%R-RNO-1483196.1 PI and PC transport between ER and Golgi membranes REELIN SIGNALLING PATHWAY%REACTOME DATABASE ID RELEASE 66%10146225 Reelin signalling pathway MRNA EDITING: A TO I CONVERSION%REACTOME%R-RNO-75064.1 mRNA Editing: A to I Conversion PHOSPHOLIPASE C-MEDIATED CASCADE; FGFR2%REACTOME DATABASE ID RELEASE 66%10146098 Phospholipase C-mediated cascade; FGFR2 MITOCHONDRIAL CALCIUM ION TRANSPORT%REACTOME%R-RNO-8949215.1 Mitochondrial calcium ion transport MITOCHONDRIAL ABC TRANSPORTERS%REACTOME%R-RNO-1369007.1 Mitochondrial ABC transporters TERMINATION OF TRANSLESION DNA SYNTHESIS%REACTOME DATABASE ID RELEASE 66%10146096 Termination of translesion DNA synthesis PEPTIDE HORMONE BIOSYNTHESIS%REACTOME%R-RNO-209952.1 Peptide hormone biosynthesis MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS%REACTOME%R-RNO-1362409.1 Mitochondrial iron-sulfur cluster biogenesis SEROTONIN NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 66%10145528 Serotonin Neurotransmitter Release Cycle LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATION FROM THE CENTROSOME%REACTOME%R-RNO-380284.1 Loss of proteins required for interphase microtubule organization from the centrosome LECTIN PATHWAY OF COMPLEMENT ACTIVATION%REACTOME%R-RNO-166662.1 Lectin pathway of complement activation FORMATION OF THE EARLY ELONGATION COMPLEX%REACTOME DATABASE ID RELEASE 66%10145012 Formation of the Early Elongation Complex PTK6 PROMOTES HIF1A STABILIZATION%REACTOME%R-RNO-8857538.1 PTK6 promotes HIF1A stabilization METABOLISM OF STEROID HORMONES%REACTOME DATABASE ID RELEASE 66%10145319 Metabolism of steroid hormones CHREBP ACTIVATES METABOLIC GENE EXPRESSION%REACTOME DATABASE ID RELEASE 66%10145124 ChREBP activates metabolic gene expression UREA CYCLE%REACTOME DATABASE ID RELEASE 66%10144786 Urea cycle MRNA EDITING%REACTOME%R-RNO-75072.1 mRNA Editing BETA OXIDATION OF LAUROYL-COA TO DECANOYL-COA-COA%REACTOME DATABASE ID RELEASE 66%10144931 Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA CASP8 ACTIVITY IS INHIBITED%REACTOME%R-RNO-5218900.1 CASP8 activity is inhibited PTK6 REGULATES CELL CYCLE%REACTOME DATABASE ID RELEASE 66%10146203 PTK6 Regulates Cell Cycle HYDROXYCARBOXYLIC ACID-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145664 Hydroxycarboxylic acid-binding receptors EFFECTS OF PIP2 HYDROLYSIS%REACTOME%R-RNO-114508.1 Effects of PIP2 hydrolysis UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A%REACTOME DATABASE ID RELEASE 66%10144752 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A SYNTHESIS OF PS%REACTOME%R-RNO-1483101.1 Synthesis of PS PHASE 4 - RESTING MEMBRANE POTENTIAL%REACTOME%R-RNO-5576886.1 Phase 4 - resting membrane potential NOTCH3 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME DATABASE ID RELEASE 66%10145951 NOTCH3 Activation and Transmission of Signal to the Nucleus BETA OXIDATION OF BUTANOYL-COA TO ACETYL-COA%REACTOME DATABASE ID RELEASE 66%10144935 Beta oxidation of butanoyl-CoA to acetyl-CoA UNWINDING OF DNA%REACTOME%R-RNO-176974.1 Unwinding of DNA PKB-MEDIATED EVENTS%REACTOME%R-RNO-109703.1 PKB-mediated events JOSEPHIN DOMAIN DUBS%REACTOME DATABASE ID RELEASE 66%10146138 Josephin domain DUBs HSP90 CHAPERONE CYCLE FOR SHRS%REACTOME DATABASE ID RELEASE 66%10146010 HSP90 chaperone cycle for SHRs NEUROFASCIN INTERACTIONS%REACTOME%R-RNO-447043.1 Neurofascin interactions COMPLEX I BIOGENESIS%REACTOME%R-RNO-6799198.1 Complex I biogenesis RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+%REACTOME%R-RNO-76005.1 Response to elevated platelet cytosolic Ca2+ GLUCONEOGENESIS%REACTOME%R-RNO-70263.1 Gluconeogenesis MAPK6 MAPK4 SIGNALING%REACTOME%R-RNO-5687128.1 MAPK6 MAPK4 signaling SIGNALING BY NUCLEAR RECEPTORS%REACTOME%R-RNO-9006931.1 Signaling by Nuclear Receptors ENOS ACTIVATION%REACTOME DATABASE ID RELEASE 66%10145394 eNOS activation GABA RECEPTOR ACTIVATION%REACTOME%R-RNO-977443.1 GABA receptor activation REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR%REACTOME DATABASE ID RELEASE 66%10145809 Regulation of gene expression by Hypoxia-inducible Factor STEROLS ARE 12-HYDROXYLATED BY CYP8B1%REACTOME%R-RNO-211994.1 Sterols are 12-hydroxylated by CYP8B1 WNT LIGAND BIOGENESIS AND TRAFFICKING%REACTOME%R-RNO-3238698.1 WNT ligand biogenesis and trafficking MET RECEPTOR ACTIVATION%REACTOME DATABASE ID RELEASE 66%10146172 MET Receptor Activation GPCR LIGAND BINDING%REACTOME DATABASE ID RELEASE 66%10145122 GPCR ligand binding TRIGLYCERIDE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 66%10144910 Triglyceride biosynthesis BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME%R-RNO-70895.1 Branched-chain amino acid catabolism NTRK2 ACTIVATES RAC1%REACTOME DATABASE ID RELEASE 66%10146322 NTRK2 activates RAC1 SIGNALING BY ERBB4%REACTOME%R-RNO-1236394.1 Signaling by ERBB4 DNA DAMAGE REVERSAL%REACTOME DATABASE ID RELEASE 66%10146231 DNA Damage Reversal DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX%REACTOME%R-RNO-3769402.1 Deactivation of the beta-catenin transactivating complex RECRUITMENT AND ATM-MEDIATED PHOSPHORYLATION OF REPAIR AND SIGNALING PROTEINS AT DNA DOUBLE STRAND BREAKS%REACTOME DATABASE ID RELEASE 66%10144760 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE%REACTOME%R-RNO-168179.1 Toll Like Receptor TLR1:TLR2 Cascade HEDGEHOG 'OFF' STATE%REACTOME%R-RNO-5610787.1 Hedgehog 'off' state APC-CDC20 MEDIATED DEGRADATION OF NEK2A%REACTOME DATABASE ID RELEASE 66%10145263 APC-Cdc20 mediated degradation of Nek2A NFG AND PRONGF BINDS TO P75NTR%REACTOME%R-RNO-205017.1 NFG and proNGF binds to p75NTR TRANSCRIPTIONAL ACTIVATION OF CELL CYCLE INHIBITOR P21%REACTOME DATABASE ID RELEASE 66%10146177 Transcriptional activation of cell cycle inhibitor p21 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS%REACTOME%R-RNO-416993.1 Trafficking of GluR2-containing AMPA receptors PROLINE CATABOLISM%REACTOME DATABASE ID RELEASE 66%10144794 Proline catabolism DEGRADATION OF GLI1 BY THE PROTEASOME%REACTOME DATABASE ID RELEASE 66%10146077 Degradation of GLI1 by the proteasome BETA OXIDATION OF DECANOYL-COA TO OCTANOYL-COA-COA%REACTOME%R-RNO-77346.1 Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA MMR%REACTOME%R-RNO-5358508.1 MMR POST-TRANSCRIPTIONAL SILENCING BY SMALL RNAS%REACTOME DATABASE ID RELEASE 66%10145622 Post-transcriptional silencing by small RNAs PI METABOLISM%REACTOME DATABASE ID RELEASE 66%10145378 PI Metabolism NEGATIVE REGULATION OF FGFR4 SIGNALING%REACTOME%R-RNO-5654733.1 Negative regulation of FGFR4 signaling NUCLEOBASE CATABOLISM%REACTOME%R-RNO-8956319.1 Nucleobase catabolism CROSS-PRESENTATION OF PARTICULATE EXOGENOUS ANTIGENS (PHAGOSOMES)%REACTOME%R-RNO-1236973.1 Cross-presentation of particulate exogenous antigens (phagosomes) MEIOSIS%REACTOME%R-RNO-1500620.1 Meiosis AKT-MEDIATED INACTIVATION OF FOXO1A%REACTOME DATABASE ID RELEASE 66%10145436 AKT-mediated inactivation of FOXO1A CREB PHOSPHORYLATION%REACTOME%R-RNO-199920.1 CREB phosphorylation RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN INTERLEUKIN SIGNALING%REACTOME DATABASE ID RELEASE 66%10146268 RUNX1 regulates transcription of genes involved in interleukin signaling SDK INTERACTIONS%REACTOME%R-RNO-373756.1 SDK interactions XENOBIOTICS%REACTOME DATABASE ID RELEASE 66%10144919 Xenobiotics SIGNALING PATHWAYS%REACTOME%R-RNO-162582.1 Signaling Pathways TRAF6 MEDIATED IRF7 ACTIVATION%REACTOME DATABASE ID RELEASE 66%10145758 TRAF6 mediated IRF7 activation NEUROTRANSMITTER RECEPTORS AND POSTSYNAPTIC SIGNAL TRANSMISSION%REACTOME%R-RNO-112314.1 Neurotransmitter receptors and postsynaptic signal transmission PLASMALOGEN BIOSYNTHESIS%REACTOME%R-RNO-75896.1 Plasmalogen biosynthesis TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING%REACTOME%R-RNO-975110.1 TRAF6 mediated IRF7 activation in TLR7 8 or 9 signaling ABACAVIR TRANSMEMBRANE TRANSPORT%REACTOME%R-RNO-2161517.1 Abacavir transmembrane transport RNA POLYMERASE I PROMOTER CLEARANCE%REACTOME%R-RNO-73854.1 RNA Polymerase I Promoter Clearance FCERI MEDIATED NF-KB ACTIVATION%REACTOME%R-RNO-2871837.1 FCERI mediated NF-kB activation THE AIM2 INFLAMMASOME%REACTOME%R-RNO-844615.1 The AIM2 inflammasome FORMATION OF RNA POL II ELONGATION COMPLEX%REACTOME%R-RNO-112382.1 Formation of RNA Pol II elongation complex NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%R-RNO-427413.1 NoRC negatively regulates rRNA expression FGFR3C LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 66%10145291 FGFR3c ligand binding and activation FATTY ACID METABOLISM%REACTOME%R-RNO-8978868.1 Fatty acid metabolism TNF RECEPTOR SUPERFAMILY (TNFSF) MEMBERS MEDIATING NON-CANONICAL NF-KB PATHWAY%REACTOME DATABASE ID RELEASE 66%10145372 TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway VEGFR2 MEDIATED VASCULAR PERMEABILITY%REACTOME%R-RNO-5218920.1 VEGFR2 mediated vascular permeability PI5P, PP2A AND IER3 REGULATE PI3K AKT SIGNALING%REACTOME%R-RNO-6811558.1 PI5P, PP2A and IER3 Regulate PI3K AKT Signaling FGFR1 LIGAND BINDING AND ACTIVATION%REACTOME%R-RNO-190242.1 FGFR1 ligand binding and activation SYNTHESIS OF PIPS AT THE ER MEMBRANE%REACTOME DATABASE ID RELEASE 66%10145900 Synthesis of PIPs at the ER membrane RHO GTPASES ACTIVATE IQGAPS%REACTOME DATABASE ID RELEASE 66%10146088 RHO GTPases activate IQGAPs RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 66%10145527 Recruitment of NuMA to mitotic centrosomes GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION%REACTOME%R-RNO-163841.1 Gamma carboxylation, hypusine formation and arylsulfatase activation GLYCINE DEGRADATION%REACTOME DATABASE ID RELEASE 66%10146148 Glycine degradation TANDEM PORE DOMAIN POTASSIUM CHANNELS%REACTOME DATABASE ID RELEASE 66%10145839 Tandem pore domain potassium channels DEGRADATION OF THE EXTRACELLULAR MATRIX%REACTOME%R-RNO-1474228.1 Degradation of the extracellular matrix ACYL CHAIN REMODELLING OF PG%REACTOME DATABASE ID RELEASE 66%10145863 Acyl chain remodelling of PG ACYL CHAIN REMODELING OF DAG AND TAG%REACTOME%R-RNO-1482883.1 Acyl chain remodeling of DAG and TAG NUCLEAR ENVELOPE BREAKDOWN%REACTOME DATABASE ID RELEASE 66%10145982 Nuclear Envelope Breakdown APC:CDC20 MEDIATED DEGRADATION OF CELL CYCLE PROTEINS PRIOR TO SATISFATION OF THE CELL CYCLE CHECKPOINT%REACTOME%R-RNO-179419.1 APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC%REACTOME DATABASE ID RELEASE 66%10145414 Antigen Presentation: Folding, assembly and peptide loading of class I MHC BLOCH PATHWAY%REACTOME%R-RNO-6807047.1 Bloch pathway RNA POLYMERASE I PROMOTER ESCAPE%REACTOME%R-RNO-73772.1 RNA Polymerase I Promoter Escape HDR THROUGH MMEJ (ALT-NHEJ)%REACTOME DATABASE ID RELEASE 66%10146137 HDR through MMEJ (alt-NHEJ) ALPHA-DEFENSINS%REACTOME%R-RNO-1462054.1 Alpha-defensins TOLL LIKE RECEPTOR 3 (TLR3) CASCADE%REACTOME DATABASE ID RELEASE 66%10145161 Toll Like Receptor 3 (TLR3) Cascade MET INTERACTS WITH TNS PROTEINS%REACTOME DATABASE ID RELEASE 66%10146251 MET interacts with TNS proteins INTERFERON GAMMA SIGNALING%REACTOME%R-RNO-877300.1 Interferon gamma signaling MAJOR PATHWAY OF RRNA PROCESSING IN THE NUCLEOLUS AND CYTOSOL%REACTOME%R-RNO-6791226.1 Major pathway of rRNA processing in the nucleolus and cytosol MET ACTIVATES STAT3%REACTOME%R-RNO-8875791.1 MET activates STAT3 ERYTHROCYTES TAKE UP CARBON DIOXIDE AND RELEASE OXYGEN%REACTOME DATABASE ID RELEASE 66%10145817 Erythrocytes take up carbon dioxide and release oxygen RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN BCR SIGNALING%REACTOME DATABASE ID RELEASE 66%10146269 RUNX1 regulates transcription of genes involved in BCR signaling G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%R-RNO-1296059.1 G protein gated Potassium channels CLEARANCE OF SERATONIN%REACTOME%R-RNO-380615.1 Clearance of seratonin MITOTIC PROMETAPHASE%REACTOME DATABASE ID RELEASE 66%10145506 Mitotic Prometaphase PLATELET SENSITIZATION BY LDL%REACTOME DATABASE ID RELEASE 66%10145634 Platelet sensitization by LDL REGULATION OF RUNX2 EXPRESSION AND ACTIVITY%REACTOME%R-RNO-8939902.1 Regulation of RUNX2 expression and activity RAB GERANYLGERANYLATION%REACTOME%R-RNO-8873719.1 RAB geranylgeranylation NEUROTRANSMITTER UPTAKE AND METABOLISM IN GLIAL CELLS%REACTOME%R-RNO-112313.1 Neurotransmitter uptake and metabolism In glial cells RAB GEFS EXCHANGE GTP FOR GDP ON RABS%REACTOME%R-RNO-8876198.1 RAB GEFs exchange GTP for GDP on RABs PRESYNAPTIC DEPOLARIZATION AND CALCIUM CHANNEL OPENING%REACTOME%R-RNO-112308.1 Presynaptic depolarization and calcium channel opening RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING%REACTOME DATABASE ID RELEASE 66%10144894 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening HISTIDINE CATABOLISM%REACTOME%R-RNO-70921.1 Histidine catabolism SIGNALING BY HIPPO%REACTOME DATABASE ID RELEASE 66%10145927 Signaling by Hippo RIBOSOMAL SCANNING AND START CODON RECOGNITION%REACTOME DATABASE ID RELEASE 66%10144836 Ribosomal scanning and start codon recognition PLATELET AGGREGATION (PLUG FORMATION)%REACTOME DATABASE ID RELEASE 66%10145477 Platelet Aggregation (Plug Formation) HEME BIOSYNTHESIS%REACTOME%R-RNO-189451.1 Heme biosynthesis NOD1 2 SIGNALING PATHWAY%REACTOME%R-RNO-168638.1 NOD1 2 Signaling Pathway INTERLEUKIN-4 AND INTERLEUKIN-13 SIGNALING%REACTOME%R-RNO-6785807.1 Interleukin-4 and Interleukin-13 signaling RELAXIN RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145665 Relaxin receptors ORGANIC CATION ANION ZWITTERION TRANSPORT%REACTOME%R-RNO-549132.1 Organic cation anion zwitterion transport CARNITINE SYNTHESIS%REACTOME DATABASE ID RELEASE 66%10144812 Carnitine synthesis CAM-PDE 1 ACTIVATION%REACTOME DATABASE ID RELEASE 66%10145008 Cam-PDE 1 activation HDR THROUGH SINGLE STRAND ANNEALING (SSA)%REACTOME DATABASE ID RELEASE 66%10144912 HDR through Single Strand Annealing (SSA) FASL CD95L SIGNALING%REACTOME%R-RNO-75157.1 FasL CD95L signaling SUMO IS PROTEOLYTICALLY PROCESSED%REACTOME%R-RNO-3065679.1 SUMO is proteolytically processed MAP2K AND MAPK ACTIVATION%REACTOME%R-RNO-5674135.1 MAP2K and MAPK activation ACTIVATION OF RAS IN B CELLS%REACTOME%R-RNO-1169092.1 Activation of RAS in B cells SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1%REACTOME DATABASE ID RELEASE 66%10145226 SCF-beta-TrCP mediated degradation of Emi1 ETHANOL OXIDATION%REACTOME DATABASE ID RELEASE 66%10144819 Ethanol oxidation RHO GTPASES REGULATE CFTR TRAFFICKING%REACTOME DATABASE ID RELEASE 66%10146090 RHO GTPases regulate CFTR trafficking FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF)%REACTOME DATABASE ID RELEASE 66%10146023 Formation of Senescence-Associated Heterochromatin Foci (SAHF) GOLGI-TO-ER RETROGRADE TRANSPORT%REACTOME%R-RNO-8856688.1 Golgi-to-ER retrograde transport REGULATION OF TP53 ACTIVITY THROUGH METHYLATION%REACTOME DATABASE ID RELEASE 66%10146002 Regulation of TP53 Activity through Methylation RESPIRATORY ELECTRON TRANSPORT%REACTOME%R-RNO-611105.1 Respiratory electron transport REVERSIBLE HYDRATION OF CARBON DIOXIDE%REACTOME%R-RNO-1475029.1 Reversible hydration of carbon dioxide SENSING OF DNA DOUBLE STRAND BREAKS%REACTOME%R-RNO-5693548.1 Sensing of DNA Double Strand Breaks NOSIP MEDIATED ENOS TRAFFICKING%REACTOME DATABASE ID RELEASE 66%10145408 NOSIP mediated eNOS trafficking BIOSYNTHESIS OF PROTECTIN AND RESOLVIN CONJUGATES IN TISSUE REGENERATION (PCTR AND RCTR)%REACTOME%R-RNO-9026766.1 Biosynthesis of protectin and resolvin conjugates in tissue regeneration (PCTR and RCTR) COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES%REACTOME%R-RNO-1650814.1 Collagen biosynthesis and modifying enzymes CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6%REACTOME%R-RNO-69017.1 CDK-mediated phosphorylation and removal of Cdc6 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24-HYDROXYCHOLESTEROL%REACTOME%R-RNO-193775.1 Synthesis of bile acids and bile salts via 24-hydroxycholesterol RUNX3 REGULATES CDKN1A TRANSCRIPTION%REACTOME%R-RNO-8941855.1 RUNX3 regulates CDKN1A transcription INTERLEUKIN-6 FAMILY SIGNALING%REACTOME%R-RNO-6783589.1 Interleukin-6 family signaling NA+ CL- DEPENDENT NEUROTRANSMITTER TRANSPORTERS%REACTOME%R-RNO-442660.1 Na+ Cl- dependent neurotransmitter transporters REGULATION OF MITOTIC CELL CYCLE%REACTOME%R-RNO-453276.1 Regulation of mitotic cell cycle ERKS ARE INACTIVATED%REACTOME DATABASE ID RELEASE 66%10145380 ERKs are inactivated PRE-NOTCH TRANSCRIPTION AND TRANSLATION%REACTOME DATABASE ID RELEASE 66%10146305 Pre-NOTCH Transcription and Translation VITAMIN B2 (RIBOFLAVIN) METABOLISM%REACTOME DATABASE ID RELEASE 66%10145350 Vitamin B2 (riboflavin) metabolism STABILIZATION OF P53%REACTOME%R-RNO-69541.1 Stabilization of p53 RESPONSE TO METAL IONS%REACTOME DATABASE ID RELEASE 66%10146118 Response to metal ions HYALURONAN METABOLISM%REACTOME%R-RNO-2142845.1 Hyaluronan metabolism ACTIVATION OF NA-PERMEABLE KAINATE RECEPTORS%REACTOME%R-RNO-451307.1 Activation of Na-permeable kainate receptors ELEVATION OF CYTOSOLIC CA2+ LEVELS%REACTOME%R-RNO-139853.1 Elevation of cytosolic Ca2+ levels TRANSLESION SYNTHESIS BY POLI%REACTOME DATABASE ID RELEASE 66%10146112 Translesion synthesis by POLI CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES)%REACTOME DATABASE ID RELEASE 66%10145812 Cross-presentation of soluble exogenous antigens (endosomes) GALACTOSE CATABOLISM%REACTOME DATABASE ID RELEASE 66%10144777 Galactose catabolism ERK MAPK TARGETS%REACTOME DATABASE ID RELEASE 66%10145363 ERK MAPK targets TRANSPORT OF GAMMA-CARBOXYLATED PROTEIN PRECURSORS FROM THE ENDOPLASMIC RETICULUM TO THE GOLGI APPARATUS%REACTOME%R-RNO-159763.1 Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus FORMATION OF TC-NER PRE-INCISION COMPLEX%REACTOME DATABASE ID RELEASE 66%10146151 Formation of TC-NER Pre-Incision Complex EICOSANOIDS%REACTOME%R-RNO-211979.1 Eicosanoids MRNA CAPPING%REACTOME DATABASE ID RELEASE 66%10144929 mRNA Capping MITOTIC SPINDLE CHECKPOINT%REACTOME DATABASE ID RELEASE 66%10145064 Mitotic Spindle Checkpoint SYNTHESIS OF HEPOXILINS (HX) AND TRIOXILINS (TRX)%REACTOME%R-RNO-2142696.1 Synthesis of Hepoxilins (HX) and Trioxilins (TrX) P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME%R-RNO-69613.1 p53-Independent G1 S DNA damage checkpoint SHC1 EVENTS IN ERBB2 SIGNALING%REACTOME DATABASE ID RELEASE 66%10145824 SHC1 events in ERBB2 signaling ACTIVATION OF MATRIX METALLOPROTEINASES%REACTOME%R-RNO-1592389.1 Activation of Matrix Metalloproteinases TANDEM OF PORE DOMAIN IN A WEAK INWARDLY RECTIFYING K+ CHANNELS (TWIK)%REACTOME DATABASE ID RELEASE 66%10145844 Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK) FRUCTOSE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 66%10146095 Fructose biosynthesis TRANSLOCATION OF ZAP-70 TO IMMUNOLOGICAL SYNAPSE%REACTOME DATABASE ID RELEASE 66%10145399 Translocation of ZAP-70 to Immunological synapse BIOSYNTHESIS OF DPAN-3-DERIVED PROTECTINS AND RESOLVINS%REACTOME%R-RNO-9026286.1 Biosynthesis of DPAn-3-derived protectins and resolvins REGULATION OF APOPTOSIS%REACTOME DATABASE ID RELEASE 66%10146243 Regulation of Apoptosis SYNTHESIS OF (16-20)-HYDROXYEICOSATETRAENOIC ACIDS (HETE)%REACTOME%R-RNO-2142816.1 Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) KERATAN SULFATE KERATIN METABOLISM%REACTOME DATABASE ID RELEASE 66%10145729 Keratan sulfate keratin metabolism CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A%REACTOME DATABASE ID RELEASE 66%10145216 Cdc20:Phospho-APC C mediated degradation of Cyclin A LDL CLEARANCE%REACTOME%R-RNO-8964038.1 LDL clearance TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX%REACTOME%R-RNO-445989.1 TAK1 activates NFkB by phosphorylation and activation of IKKs complex CHEMOKINE RECEPTORS BIND CHEMOKINES%REACTOME%R-RNO-380108.1 Chemokine receptors bind chemokines AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL%REACTOME%R-RNO-198323.1 AKT phosphorylates targets in the cytosol PROCESSING OF DNA DOUBLE-STRAND BREAK ENDS%REACTOME DATABASE ID RELEASE 66%10146130 Processing of DNA double-strand break ends CARGO TRAFFICKING TO THE PERICILIARY MEMBRANE%REACTOME DATABASE ID RELEASE 66%10146079 Cargo trafficking to the periciliary membrane GLYCEROPHOSPHOLIPID BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 66%10144908 Glycerophospholipid biosynthesis NEUROPHILIN INTERACTIONS WITH VEGF AND VEGFR%REACTOME%R-RNO-194306.1 Neurophilin interactions with VEGF and VEGFR DNA REPLICATION PRE-INITIATION%REACTOME DATABASE ID RELEASE 66%10144714 DNA Replication Pre-Initiation PRESYNAPTIC FUNCTION OF KAINATE RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145706 Presynaptic function of Kainate receptors NADPH REGENERATION%REACTOME DATABASE ID RELEASE 66%10145547 NADPH regeneration KERATAN SULFATE DEGRADATION%REACTOME%R-RNO-2022857.1 Keratan sulfate degradation BIOSYNTHESIS OF D-SERIES RESOLVINS%REACTOME DATABASE ID RELEASE 66%10146303 Biosynthesis of D-series resolvins AMPLIFICATION OF SIGNAL FROM THE KINETOCHORES%REACTOME%R-RNO-141424.1 Amplification of signal from the kinetochores REGULATION OF INSULIN SECRETION%REACTOME DATABASE ID RELEASE 66%10145114 Regulation of insulin secretion INTERLEUKIN-23 SIGNALING%REACTOME%R-RNO-9020933.1 Interleukin-23 signaling CALCINEURIN ACTIVATES NFAT%REACTOME DATABASE ID RELEASE 66%10145926 Calcineurin activates NFAT RNA POLYMERASE I TRANSCRIPTION%REACTOME%R-RNO-73864.1 RNA Polymerase I Transcription SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS%REACTOME%R-RNO-75876.1 Synthesis of very long-chain fatty acyl-CoAs REGULATION OF COMPLEMENT CASCADE%REACTOME%R-RNO-977606.1 Regulation of Complement cascade MTORC1-MEDIATED SIGNALLING%REACTOME%R-RNO-166208.1 mTORC1-mediated signalling METABOLISM OF POLYAMINES%REACTOME%R-RNO-351202.1 Metabolism of polyamines G2 M CHECKPOINTS%REACTOME DATABASE ID RELEASE 66%10144759 G2 M Checkpoints ORGANIC CATION TRANSPORT%REACTOME%R-RNO-549127.1 Organic cation transport TRANSCRIPTIONAL ACTIVATION OF P53 RESPONSIVE GENES%REACTOME DATABASE ID RELEASE 66%10146178 Transcriptional activation of p53 responsive genes CREATION OF C4 AND C2 ACTIVATORS%REACTOME DATABASE ID RELEASE 66%10145209 Creation of C4 and C2 activators GLUCOSE METABOLISM%REACTOME%R-RNO-70326.1 Glucose metabolism INTERLEUKIN-27 SIGNALING%REACTOME%R-RNO-9020956.1 Interleukin-27 signaling TRANSCRIPTIONAL REGULATION BY THE AP-2 (TFAP2) FAMILY OF TRANSCRIPTION FACTORS%REACTOME%R-RNO-8864260.1 Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION)%REACTOME%R-RNO-2173791.1 TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) NEGATIVE REGULATION OF TCF-DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS%REACTOME DATABASE ID RELEASE 66%10146021 Negative regulation of TCF-dependent signaling by WNT ligand antagonists BETA OXIDATION OF OCTANOYL-COA TO HEXANOYL-COA%REACTOME DATABASE ID RELEASE 66%10144937 Beta oxidation of octanoyl-CoA to hexanoyl-CoA RAB REGULATION OF TRAFFICKING%REACTOME DATABASE ID RELEASE 66%10146223 Rab regulation of trafficking NEUREXINS AND NEUROLIGINS%REACTOME%R-RNO-6794361.1 Neurexins and neuroligins FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS%REACTOME%R-RNO-2029480.1 Fcgamma receptor (FCGR) dependent phagocytosis ENDOGENOUS STEROLS%REACTOME DATABASE ID RELEASE 66%10145314 Endogenous sterols SPRY REGULATION OF FGF SIGNALING%REACTOME DATABASE ID RELEASE 66%10145760 Spry regulation of FGF signaling ER-PHAGOSOME PATHWAY%REACTOME DATABASE ID RELEASE 66%10145816 ER-Phagosome pathway OTHER SEMAPHORIN INTERACTIONS%REACTOME%R-RNO-416700.1 Other semaphorin interactions SIGNALING BY BMP%REACTOME DATABASE ID RELEASE 66%10145385 Signaling by BMP NEGATIVE REGULATION OF FGFR2 SIGNALING%REACTOME DATABASE ID RELEASE 66%10145762 Negative regulation of FGFR2 signaling REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF)%REACTOME DATABASE ID RELEASE 66%10145896 Regulation of cholesterol biosynthesis by SREBP (SREBF) APOPTOSIS%REACTOME DATABASE ID RELEASE 66%10144862 Apoptosis DERMATAN SULFATE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 66%10145924 Dermatan sulfate biosynthesis CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION%REACTOME DATABASE ID RELEASE 66%10144735 Cyclin E associated events during G1 S transition BIOGENIC AMINES ARE OXIDATIVELY DEAMINATED TO ALDEHYDES BY MAOA AND MAOB%REACTOME DATABASE ID RELEASE 66%10145055 Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB TNF SIGNALING%REACTOME%R-RNO-75893.1 TNF signaling DIGESTION OF DIETARY CARBOHYDRATE%REACTOME%R-RNO-189085.1 Digestion of dietary carbohydrate PLATELET DEGRANULATION%REACTOME DATABASE ID RELEASE 66%10145469 Platelet degranulation PROGRAMMED CELL DEATH%REACTOME%R-RNO-5357801.1 Programmed Cell Death SIGNALING BY NOTCH2%REACTOME DATABASE ID RELEASE 66%10145921 Signaling by NOTCH2 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS)%REACTOME DATABASE ID RELEASE 66%10145487 Class A 1 (Rhodopsin-like receptors) TELOMERE C-STRAND SYNTHESIS INITIATION%REACTOME DATABASE ID RELEASE 66%10145233 Telomere C-strand synthesis initiation DCC MEDIATED ATTRACTIVE SIGNALING%REACTOME%R-RNO-418885.1 DCC mediated attractive signaling THE FATTY ACID CYCLING MODEL%REACTOME DATABASE ID RELEASE 66%10145135 The fatty acid cycling model SYNTHESIS OF UDP-N-ACETYL-GLUCOSAMINE%REACTOME%R-RNO-446210.1 Synthesis of UDP-N-acetyl-glucosamine HYALURONAN BIOSYNTHESIS AND EXPORT%REACTOME%R-RNO-2142850.1 Hyaluronan biosynthesis and export SMOOTH MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 66%10145669 Smooth Muscle Contraction DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX%REACTOME%R-RNO-195253.1 Degradation of beta-catenin by the destruction complex POLO-LIKE KINASE MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 66%10145073 Polo-like kinase mediated events SYNTHESIS OF 12-EICOSATETRAENOIC ACID DERIVATIVES%REACTOME DATABASE ID RELEASE 66%10145948 Synthesis of 12-eicosatetraenoic acid derivatives BETAKLOTHO-MEDIATED LIGAND BINDING%REACTOME%R-RNO-1307965.1 betaKlotho-mediated ligand binding CYCLIN D ASSOCIATED EVENTS IN G1%REACTOME DATABASE ID RELEASE 66%10144736 Cyclin D associated events in G1 DNA DOUBLE-STRAND BREAK REPAIR%REACTOME DATABASE ID RELEASE 66%10144762 DNA Double-Strand Break Repair NICOTINATE METABOLISM%REACTOME%R-RNO-196807.1 Nicotinate metabolism ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS%REACTOME DATABASE ID RELEASE 66%10145788 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION)%REACTOME%R-RNO-70614.1 Amino acid synthesis and interconversion (transamination) TRANSPORT OF ORGANIC ANIONS%REACTOME DATABASE ID RELEASE 66%10145337 Transport of organic anions NIK-->NONCANONICAL NF-KB SIGNALING%REACTOME DATABASE ID RELEASE 66%10146074 NIK-->noncanonical NF-kB signaling HISTAMINE RECEPTORS%REACTOME%R-RNO-390650.1 Histamine receptors SHC-MEDIATED CASCADE:FGFR4%REACTOME%R-RNO-5654719.1 SHC-mediated cascade:FGFR4 APEX1-INDEPENDENT RESOLUTION OF AP SITES VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 66%10146092 APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway UNFOLDED PROTEIN RESPONSE (UPR)%REACTOME DATABASE ID RELEASE 66%10145530 Unfolded Protein Response (UPR) STIMULI-SENSING CHANNELS%REACTOME%R-RNO-2672351.1 Stimuli-sensing channels GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS)%REACTOME DATABASE ID RELEASE 66%10144780 Glycogen breakdown (glycogenolysis) B CELL ACTIVATION%REACTOME DATABASE ID RELEASE 66%10145789 B Cell Activation PTK6 REGULATES RHO GTPASES, RAS GTPASE AND MAP KINASES%REACTOME DATABASE ID RELEASE 66%10146205 PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases EPH-EPHRIN SIGNALING%REACTOME DATABASE ID RELEASE 66%10146025 EPH-Ephrin signaling TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN CYTOCHROME C RELEASE%REACTOME%R-RNO-6803204.1 TP53 Regulates Transcription of Genes Involved in Cytochrome C Release POLYMERASE SWITCHING%REACTOME DATABASE ID RELEASE 66%10144729 Polymerase switching PERK REGULATES GENE EXPRESSION%REACTOME DATABASE ID RELEASE 66%10145531 PERK regulates gene expression REGULATION OF RUNX3 EXPRESSION AND ACTIVITY%REACTOME%R-RNO-8941858.1 Regulation of RUNX3 expression and activity LIGAND-RECEPTOR INTERACTIONS%REACTOME DATABASE ID RELEASE 66%10145666 Ligand-receptor interactions PLATELET HOMEOSTASIS%REACTOME DATABASE ID RELEASE 66%10145040 Platelet homeostasis CLASSICAL ANTIBODY-MEDIATED COMPLEMENT ACTIVATION%REACTOME%R-RNO-173623.1 Classical antibody-mediated complement activation ZINC TRANSPORTERS%REACTOME DATABASE ID RELEASE 66%10145654 Zinc transporters TRANSCRIPTIONAL REGULATION BY SMALL RNAS%REACTOME DATABASE ID RELEASE 66%10146071 Transcriptional regulation by small RNAs INTERFERON SIGNALING%REACTOME%R-RNO-913531.1 Interferon Signaling IRS ACTIVATION%REACTOME DATABASE ID RELEASE 66%10144874 IRS activation BUTYROPHILIN (BTN) FAMILY INTERACTIONS%REACTOME%R-RNO-8851680.1 Butyrophilin (BTN) family interactions NUCLEOTIDE SALVAGE%REACTOME%R-RNO-8956321.1 Nucleotide salvage COENZYME A BIOSYNTHESIS%REACTOME%R-RNO-196783.1 Coenzyme A biosynthesis TRANSLESION SYNTHESIS BY POLK%REACTOME DATABASE ID RELEASE 66%10146111 Translesion synthesis by POLK KERATINIZATION%REACTOME%R-RNO-6805567.1 Keratinization MRNA 3'-END PROCESSING%REACTOME DATABASE ID RELEASE 66%10144830 mRNA 3'-end processing MITOCHONDRIAL BIOGENESIS%REACTOME DATABASE ID RELEASE 66%10145879 Mitochondrial biogenesis RIP-MEDIATED NFKB ACTIVATION VIA ZBP1%REACTOME%R-RNO-1810476.1 RIP-mediated NFkB activation via ZBP1 TWIK-RELEATED ACID-SENSITIVE K+ CHANNEL (TASK)%REACTOME DATABASE ID RELEASE 66%10145845 TWIK-releated acid-sensitive K+ channel (TASK) FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX%REACTOME DATABASE ID RELEASE 66%10144838 Formation of the ternary complex, and subsequently, the 43S complex GLYCOGEN SYNTHESIS%REACTOME%R-RNO-3322077.1 Glycogen synthesis IRAK1 RECRUITS IKK COMPLEX%REACTOME DATABASE ID RELEASE 66%10145768 IRAK1 recruits IKK complex G2 M DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 66%10144758 G2 M DNA damage checkpoint SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%R-RNO-427359.1 SIRT1 negatively regulates rRNA expression CONDENSATION OF PROMETAPHASE CHROMOSOMES%REACTOME DATABASE ID RELEASE 66%10145973 Condensation of Prometaphase Chromosomes NEGATIVE REGULATION OF FGFR3 SIGNALING%REACTOME%R-RNO-5654732.1 Negative regulation of FGFR3 signaling NEDDYLATION%REACTOME DATABASE ID RELEASE 66%10146142 Neddylation ORGANELLE BIOGENESIS AND MAINTENANCE%REACTOME DATABASE ID RELEASE 66%10145880 Organelle biogenesis and maintenance P53-INDEPENDENT DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 66%10144753 p53-Independent DNA Damage Response TFAP2 (AP-2) FAMILY REGULATES TRANSCRIPTION OF CELL CYCLE FACTORS%REACTOME%R-RNO-8866911.1 TFAP2 (AP-2) family regulates transcription of cell cycle factors REGULATION OF IFNG SIGNALING%REACTOME DATABASE ID RELEASE 66%10145739 Regulation of IFNG signaling FGFR1C LIGAND BINDING AND ACTIVATION%REACTOME%R-RNO-190373.1 FGFR1c ligand binding and activation REGULATION OF RAS BY GAPS%REACTOME%R-RNO-5658442.1 Regulation of RAS by GAPs RETROGRADE TRANSPORT AT THE TRANS-GOLGI-NETWORK%REACTOME%R-RNO-6811440.1 Retrograde transport at the Trans-Golgi-Network TRANSLOCATION OF SLC2A4 (GLUT4) TO THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 66%10145854 Translocation of SLC2A4 (GLUT4) to the plasma membrane ACTIVATION OF NMDA RECEPTORS AND POSTSYNAPTIC EVENTS%REACTOME%R-RNO-442755.1 Activation of NMDA receptors and postsynaptic events INTERACTION WITH CUMULUS CELLS%REACTOME DATABASE ID RELEASE 66%10145974 Interaction With Cumulus Cells INTERLEUKIN-9 SIGNALING%REACTOME%R-RNO-8985947.1 Interleukin-9 signaling SIGNALING BY NOTCH%REACTOME DATABASE ID RELEASE 66%10145914 Signaling by NOTCH SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE%REACTOME DATABASE ID RELEASE 66%10144727 Switching of origins to a post-replicative state SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA-HYDROXYCHOLESTEROL%REACTOME DATABASE ID RELEASE 66%10145313 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 66%10145498 Semaphorin interactions CREATINE METABOLISM%REACTOME DATABASE ID RELEASE 66%10144813 Creatine metabolism PHOSPHORYLATION OF PROTEINS INVOLVED IN G1 S TRANSITION BY ACTIVE CYCLIN E:CDK2 COMPLEXES%REACTOME DATABASE ID RELEASE 66%10145275 Phosphorylation of proteins involved in G1 S transition by active Cyclin E:Cdk2 complexes INTRINSIC PATHWAY OF FIBRIN CLOT FORMATION%REACTOME DATABASE ID RELEASE 66%10145080 Intrinsic Pathway of Fibrin Clot Formation RUNX1 INTERACTS WITH CO-FACTORS WHOSE PRECISE EFFECT ON RUNX1 TARGETS IS NOT KNOWN%REACTOME%R-RNO-8939243.1 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known SUMO IS TRANSFERRED FROM E1 TO E2 (UBE2I, UBC9)%REACTOME DATABASE ID RELEASE 66%10145988 SUMO is transferred from E1 to E2 (UBE2I, UBC9) VITAMIN D (CALCIFEROL) METABOLISM%REACTOME%R-RNO-196791.1 Vitamin D (calciferol) metabolism ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM%REACTOME%R-RNO-2046104.1 alpha-linolenic (omega3) and linoleic (omega6) acid metabolism KERATAN SULFATE BIOSYNTHESIS%REACTOME%R-RNO-2022854.1 Keratan sulfate biosynthesis ACTIVATION OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 66%10144723 Activation of the pre-replicative complex HCN CHANNELS%REACTOME%R-RNO-1296061.1 HCN channels SUMOYLATION OF DNA REPLICATION PROTEINS%REACTOME%R-RNO-4615885.1 SUMOylation of DNA replication proteins HEDGEHOG 'ON' STATE%REACTOME%R-RNO-5632684.1 Hedgehog 'on' state FRS2-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 66%10145200 Frs2-mediated activation G BETA:GAMMA SIGNALLING THROUGH PLC BETA%REACTOME DATABASE ID RELEASE 66%10145577 G beta:gamma signalling through PLC beta INHIBITION OF TSC COMPLEX FORMATION BY PKB%REACTOME%R-RNO-165181.1 Inhibition of TSC complex formation by PKB NEGATIVE REGULATION OF FGFR1 SIGNALING%REACTOME%R-RNO-5654726.1 Negative regulation of FGFR1 signaling PLASMA LIPOPROTEIN REMODELING%REACTOME%R-RNO-8963899.1 Plasma lipoprotein remodeling AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE%REACTOME%R-RNO-352230.1 Amino acid transport across the plasma membrane APOPTOSIS INDUCED DNA FRAGMENTATION%REACTOME DATABASE ID RELEASE 66%10145440 Apoptosis induced DNA fragmentation NF-KB IS ACTIVATED AND SIGNALS SURVIVAL%REACTOME%R-RNO-209560.1 NF-kB is activated and signals survival CELLULAR RESPONSE TO HEAT STRESS%REACTOME%R-RNO-3371556.1 Cellular response to heat stress TRANSPORT OF NUCLEOTIDE SUGARS%REACTOME%R-RNO-727802.1 Transport of nucleotide sugars SEPARATION OF SISTER CHROMATIDS%REACTOME DATABASE ID RELEASE 66%10145223 Separation of Sister Chromatids GAMMA-CARBOXYLATION OF PROTEIN PRECURSORS%REACTOME%R-RNO-159740.1 Gamma-carboxylation of protein precursors REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND%REACTOME DATABASE ID RELEASE 66%10145237 Removal of the Flap Intermediate from the C-strand SMAC-MEDIATED APOPTOTIC RESPONSE%REACTOME DATABASE ID RELEASE 66%10145021 SMAC-mediated apoptotic response PI-3K CASCADE:FGFR1%REACTOME%R-RNO-5654689.1 PI-3K cascade:FGFR1 METABOLISM OF COFACTORS%REACTOME DATABASE ID RELEASE 66%10145548 Metabolism of cofactors EUKARYOTIC TRANSLATION ELONGATION%REACTOME%R-RNO-156842.1 Eukaryotic Translation Elongation TELOMERE EXTENSION BY TELOMERASE%REACTOME DATABASE ID RELEASE 66%10145110 Telomere Extension By Telomerase SIGNALLING TO ERKS%REACTOME DATABASE ID RELEASE 66%10145182 Signalling to ERKs LAGGING STRAND SYNTHESIS%REACTOME%R-RNO-69186.1 Lagging Strand Synthesis POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS%REACTOME DATABASE ID RELEASE 66%10145102 Post-translational modification: synthesis of GPI-anchored proteins DIGESTION OF DIETARY LIPID%REACTOME%R-RNO-192456.1 Digestion of dietary lipid WNT5A-DEPENDENT INTERNALIZATION OF FZD4%REACTOME DATABASE ID RELEASE 66%10146042 WNT5A-dependent internalization of FZD4 COMMON PATHWAY OF FIBRIN CLOT FORMATION%REACTOME%R-RNO-140875.1 Common Pathway of Fibrin Clot Formation ACYL CHAIN REMODELLING OF PS%REACTOME DATABASE ID RELEASE 66%10145868 Acyl chain remodelling of PS ASSEMBLY OF THE ORC COMPLEX AT THE ORIGIN OF REPLICATION%REACTOME DATABASE ID RELEASE 66%10144712 Assembly of the ORC complex at the origin of replication HSF1 ACTIVATION%REACTOME%R-RNO-3371511.1 HSF1 activation NON-CODING RNA METABOLISM%REACTOME%R-RNO-194441.1 Non-coding RNA Metabolism REGULATION OF TP53 ACTIVITY THROUGH PHOSPHORYLATION%REACTOME DATABASE ID RELEASE 66%10144756 Regulation of TP53 Activity through Phosphorylation MITOCHONDRIAL TRANSLATION TERMINATION%REACTOME DATABASE ID RELEASE 66%10146065 Mitochondrial translation termination CONJUGATION OF CARBOXYLIC ACIDS%REACTOME DATABASE ID RELEASE 66%10145090 Conjugation of carboxylic acids OPSINS%REACTOME%R-RNO-419771.1 Opsins TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES%REACTOME DATABASE ID RELEASE 66%10144951 Transport of vitamins, nucleosides, and related molecules EICOSANOID LIGAND-BINDING RECEPTORS%REACTOME%R-RNO-391903.1 Eicosanoid ligand-binding receptors FRUCTOSE METABOLISM%REACTOME%R-RNO-5652084.1 Fructose metabolism B-WICH COMPLEX POSITIVELY REGULATES RRNA EXPRESSION%REACTOME DATABASE ID RELEASE 66%10146051 B-WICH complex positively regulates rRNA expression PCNA-DEPENDENT LONG PATCH BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 66%10144982 PCNA-Dependent Long Patch Base Excision Repair TNFS BIND THEIR PHYSIOLOGICAL RECEPTORS%REACTOME DATABASE ID RELEASE 66%10146122 TNFs bind their physiological receptors INTERLEUKIN-37 SIGNALING%REACTOME DATABASE ID RELEASE 66%10146292 Interleukin-37 signaling RETROGRADE NEUROTROPHIN SIGNALLING%REACTOME%R-RNO-177504.1 Retrograde neurotrophin signalling PRPP BIOSYNTHESIS%REACTOME%R-RNO-73843.1 PRPP biosynthesis RHO GTPASES ACTIVATE KTN1%REACTOME%R-RNO-5625970.1 RHO GTPases activate KTN1 PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS%REACTOME%R-RNO-202427.1 Phosphorylation of CD3 and TCR zeta chains ACTIVATION OF GABAB RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145188 Activation of GABAB receptors CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS%REACTOME%R-RNO-442742.1 CREB phosphorylation through the activation of Ras ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 66%10145158 Activation of the AP-1 family of transcription factors SYNTHESIS OF DOLICHYL-PHOSPHATE-GLUCOSE%REACTOME DATABASE ID RELEASE 66%10145673 Synthesis of dolichyl-phosphate-glucose PTK6 REGULATES RTKS AND THEIR EFFECTORS AKT1 AND DOK1%REACTOME DATABASE ID RELEASE 66%10146206 PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 COHESIN LOADING ONTO CHROMATIN%REACTOME%R-RNO-2470946.1 Cohesin Loading onto Chromatin SEMA3A PAK DEPENDENT AXON REPULSION%REACTOME DATABASE ID RELEASE 66%10145582 Sema3A PAK dependent Axon repulsion ATTENUATION PHASE%REACTOME DATABASE ID RELEASE 66%10146014 Attenuation phase RNA POLYMERASE II TRANSCRIPTION%REACTOME DATABASE ID RELEASE 66%10144750 RNA Polymerase II Transcription ROLE OF ABL IN ROBO-SLIT SIGNALING%REACTOME%R-RNO-428890.1 Role of ABL in ROBO-SLIT signaling SIGNALING BY FGFR3%REACTOME DATABASE ID RELEASE 66%10145259 Signaling by FGFR3 COLLAGEN FORMATION%REACTOME%R-RNO-1474290.1 Collagen formation DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION%REACTOME%R-RNO-3134963.1 DEx H-box helicases activate type I IFN and inflammatory cytokines production SUMOYLATION OF SUMOYLATION PROTEINS%REACTOME DATABASE ID RELEASE 66%10146029 SUMOylation of SUMOylation proteins REGULATED NECROSIS%REACTOME%R-RNO-5218859.1 Regulated Necrosis SYNTHESIS OF 15-EICOSATETRAENOIC ACID DERIVATIVES%REACTOME DATABASE ID RELEASE 66%10145944 Synthesis of 15-eicosatetraenoic acid derivatives EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA%REACTOME%R-RNO-212718.1 EGFR interacts with phospholipase C-gamma PHOSPHORYLATION OF EMI1%REACTOME DATABASE ID RELEASE 66%10145225 Phosphorylation of Emi1 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY%REACTOME%R-RNO-3301854.1 Nuclear Pore Complex (NPC) Disassembly REPRESSION OF WNT TARGET GENES%REACTOME DATABASE ID RELEASE 66%10146038 Repression of WNT target genes APOPTOTIC EXECUTION PHASE%REACTOME DATABASE ID RELEASE 66%10145388 Apoptotic execution phase RUNX3 REGULATES NOTCH SIGNALING%REACTOME%R-RNO-8941856.1 RUNX3 regulates NOTCH signaling VEGFR2 MEDIATED CELL PROLIFERATION%REACTOME DATABASE ID RELEASE 66%10146032 VEGFR2 mediated cell proliferation NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145596 Nucleotide-like (purinergic) receptors SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 27-HYDROXYCHOLESTEROL%REACTOME%R-RNO-193807.1 Synthesis of bile acids and bile salts via 27-hydroxycholesterol INTEGRIN SIGNALING%REACTOME DATABASE ID RELEASE 66%10145478 Integrin signaling G ALPHA (I) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 66%10144868 G alpha (i) signalling events TRANSMISSION ACROSS CHEMICAL SYNAPSES%REACTOME%R-RNO-112315.1 Transmission across Chemical Synapses FGFR2 LIGAND BINDING AND ACTIVATION%REACTOME%R-RNO-190241.1 FGFR2 ligand binding and activation SIGNALING BY NON-RECEPTOR TYROSINE KINASES%REACTOME DATABASE ID RELEASE 66%10146199 Signaling by Non-Receptor Tyrosine Kinases CARDIAC CONDUCTION%REACTOME%R-RNO-5576891.1 Cardiac conduction TBC RABGAPS%REACTOME DATABASE ID RELEASE 66%10146222 TBC RABGAPs FBXL7 DOWN-REGULATES AURKA DURING MITOTIC ENTRY AND IN EARLY MITOSIS%REACTOME%R-RNO-8854050.1 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis COPI-INDEPENDENT GOLGI-TO-ER RETROGRADE TRAFFIC%REACTOME%R-RNO-6811436.1 COPI-independent Golgi-to-ER retrograde traffic TANDEM PORE DOMAIN HALOTHANE-INHIBITED K+ CHANNEL (THIK)%REACTOME DATABASE ID RELEASE 66%10145843 Tandem pore domain halothane-inhibited K+ channel (THIK) PYROPHOSPHATE HYDROLYSIS%REACTOME%R-RNO-71737.1 Pyrophosphate hydrolysis MITOPHAGY%REACTOME DATABASE ID RELEASE 66%10146046 Mitophagy LYSOSOMAL OLIGOSACCHARIDE CATABOLISM%REACTOME DATABASE ID RELEASE 66%10146170 Lysosomal oligosaccharide catabolism POTASSIUM CHANNELS%REACTOME%R-RNO-1296071.1 Potassium Channels PI3K CASCADE%REACTOME DATABASE ID RELEASE 66%10144954 PI3K Cascade BREAKDOWN OF THE NUCLEAR LAMINA%REACTOME%R-RNO-352238.1 Breakdown of the nuclear lamina ACTIVATION, TRANSLOCATION AND OLIGOMERIZATION OF BAX%REACTOME DATABASE ID RELEASE 66%10145017 Activation, translocation and oligomerization of BAX ENDOSOMAL VACUOLAR PATHWAY%REACTOME%R-RNO-1236977.1 Endosomal Vacuolar pathway ABACAVIR METABOLISM%REACTOME%R-RNO-2161541.1 Abacavir metabolism PROTEIN FOLDING%REACTOME%R-RNO-391251.1 Protein folding ACTIVATION OF BIM AND TRANSLOCATION TO MITOCHONDRIA%REACTOME DATABASE ID RELEASE 66%10145048 Activation of BIM and translocation to mitochondria SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION%REACTOME%R-RNO-399955.1 SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion SIGNALING BY NTRKS%REACTOME%R-RNO-166520.1 Signaling by NTRKs HUR (ELAVL1) BINDS AND STABILIZES MRNA%REACTOME DATABASE ID RELEASE 66%10145693 HuR (ELAVL1) binds and stabilizes mRNA INTESTINAL LIPID ABSORPTION%REACTOME DATABASE ID RELEASE 66%10145460 Intestinal lipid absorption RNA POLYMERASE I PROMOTER OPENING%REACTOME DATABASE ID RELEASE 66%10144847 RNA Polymerase I Promoter Opening INTEGRIN CELL SURFACE INTERACTIONS%REACTOME%R-RNO-216083.1 Integrin cell surface interactions TNFR2 NON-CANONICAL NF-KB PATHWAY%REACTOME DATABASE ID RELEASE 66%10145373 TNFR2 non-canonical NF-kB pathway N-GLYCAN TRIMMING AND ELONGATION IN THE CIS-GOLGI%REACTOME DATABASE ID RELEASE 66%10145771 N-glycan trimming and elongation in the cis-Golgi FRS-MEDIATED FGFR4 SIGNALING%REACTOME DATABASE ID RELEASE 66%10146106 FRS-mediated FGFR4 signaling G-PROTEIN ACTIVATION%REACTOME%R-RNO-202040.1 G-protein activation OXIDATIVE STRESS INDUCED SENESCENCE%REACTOME DATABASE ID RELEASE 66%10145165 Oxidative Stress Induced Senescence TACHYKININ RECEPTORS BIND TACHYKININS%REACTOME DATABASE ID RELEASE 66%10145521 Tachykinin receptors bind tachykinins GLOBAL GENOME NUCLEOTIDE EXCISION REPAIR (GG-NER)%REACTOME%R-RNO-5696399.1 Global Genome Nucleotide Excision Repair (GG-NER) CENTROSOME MATURATION%REACTOME%R-RNO-380287.1 Centrosome maturation CHROMATIN ORGANIZATION%REACTOME DATABASE ID RELEASE 66%10145803 Chromatin organization EXTENSION OF TELOMERES%REACTOME DATABASE ID RELEASE 66%10145111 Extension of Telomeres CDO IN MYOGENESIS%REACTOME DATABASE ID RELEASE 66%10145503 CDO in myogenesis GAP JUNCTION TRAFFICKING AND REGULATION%REACTOME DATABASE ID RELEASE 66%10145298 Gap junction trafficking and regulation GLUTATHIONE SYNTHESIS AND RECYCLING%REACTOME%R-RNO-174403.1 Glutathione synthesis and recycling INTERLEUKIN-3, INTERLEUKIN-5 AND GM-CSF SIGNALING%REACTOME DATABASE ID RELEASE 66%10145705 Interleukin-3, Interleukin-5 and GM-CSF signaling ACYL CHAIN REMODELLING OF PC%REACTOME%R-RNO-1482788.1 Acyl chain remodelling of PC INTERLEUKIN-1 SIGNALING%REACTOME%R-RNO-9020702.1 Interleukin-1 signaling G0 AND EARLY G1%REACTOME%R-RNO-1538133.1 G0 and Early G1 ACTIVATION OF CAMK IV%REACTOME%R-RNO-442745.1 Activation of CaMK IV ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%R-RNO-1296041.1 Activation of G protein gated Potassium channels DUAL INCISION IN TC-NER%REACTOME%R-RNO-6782135.1 Dual incision in TC-NER CYTOSOLIC TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 66%10144822 Cytosolic tRNA aminoacylation ELECTRON TRANSPORT FROM NADPH TO FERREDOXIN%REACTOME%R-RNO-2395516.1 Electron transport from NADPH to Ferredoxin VEGF LIGAND-RECEPTOR INTERACTIONS%REACTOME DATABASE ID RELEASE 66%10145339 VEGF ligand-receptor interactions YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION%REACTOME%R-RNO-2032785.1 YAP1- and WWTR1 (TAZ)-stimulated gene expression DNA REPAIR%REACTOME DATABASE ID RELEASE 66%10144763 DNA Repair REGULATION OF NECROPTOTIC CELL DEATH%REACTOME DATABASE ID RELEASE 66%10146017 Regulation of necroptotic cell death INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1%REACTOME DATABASE ID RELEASE 66%10145013 Inhibition of replication initiation of damaged DNA by RB1 E2F1 RECOGNITION OF DNA DAMAGE BY PCNA-CONTAINING REPLICATION COMPLEX%REACTOME DATABASE ID RELEASE 66%10146094 Recognition of DNA damage by PCNA-containing replication complex SYNAPTIC ADHESION-LIKE MOLECULES%REACTOME DATABASE ID RELEASE 66%10146209 Synaptic adhesion-like molecules VEGF BINDS TO VEGFR LEADING TO RECEPTOR DIMERIZATION%REACTOME DATABASE ID RELEASE 66%10145338 VEGF binds to VEGFR leading to receptor dimerization THE ACTIVATION OF ARYLSULFATASES%REACTOME DATABASE ID RELEASE 66%10145887 The activation of arylsulfatases LINOLEIC ACID (LA) METABOLISM%REACTOME DATABASE ID RELEASE 66%10145933 Linoleic acid (LA) metabolism FORMATION OF ANNULAR GAP JUNCTIONS%REACTOME%R-RNO-196025.1 Formation of annular gap junctions CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM%REACTOME DATABASE ID RELEASE 66%10145886 Chondroitin sulfate dermatan sulfate metabolism INTERLEUKIN-12 FAMILY SIGNALING%REACTOME%R-RNO-447115.1 Interleukin-12 family signaling TOLL LIKE RECEPTOR 10 (TLR10) CASCADE%REACTOME%R-RNO-168142.1 Toll Like Receptor 10 (TLR10) Cascade BIOSYNTHESIS OF ASPIRIN-TRIGGERED D-SERIES RESOLVINS%REACTOME%R-RNO-9020265.1 Biosynthesis of aspirin-triggered D-series resolvins ADENYLATE CYCLASE INHIBITORY PATHWAY%REACTOME DATABASE ID RELEASE 66%10145186 Adenylate cyclase inhibitory pathway HYDROLYSIS OF LPC%REACTOME%R-RNO-1483115.1 Hydrolysis of LPC PRE-NOTCH EXPRESSION AND PROCESSING%REACTOME DATABASE ID RELEASE 66%10145916 Pre-NOTCH Expression and Processing CD22 MEDIATED BCR REGULATION%REACTOME DATABASE ID RELEASE 66%10146141 CD22 mediated BCR regulation ACTIVATION OF NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%R-RNO-629602.1 Activation of Nicotinic Acetylcholine Receptors TRANSCRIPTION FROM MITOCHONDRIAL PROMOTERS%REACTOME DATABASE ID RELEASE 66%10145118 Transcription from mitochondrial promoters DOPAMINE RECEPTORS%REACTOME%R-RNO-390651.1 Dopamine receptors SYNTHESIS OF EPOXY (EET) AND DIHYDROXYEICOSATRIENOIC ACIDS (DHET)%REACTOME DATABASE ID RELEASE 66%10145947 Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK%REACTOME DATABASE ID RELEASE 66%10145383 Energy dependent regulation of mTOR by LKB1-AMPK BIOSYNTHESIS OF E-SERIES 18(S)-RESOLVINS%REACTOME%R-RNO-9018896.1 Biosynthesis of E-series 18(S)-resolvins SYNTHESIS OF PA%REACTOME DATABASE ID RELEASE 66%10144907 Synthesis of PA NOSTRIN MEDIATED ENOS TRAFFICKING%REACTOME%R-RNO-203641.1 NOSTRIN mediated eNOS trafficking DEPYRIMIDINATION%REACTOME DATABASE ID RELEASE 66%10144972 Depyrimidination PHYSIOLOGICAL FACTORS%REACTOME%R-RNO-5578768.1 Physiological factors JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1%REACTOME%R-RNO-450321.1 JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 DNA STRAND ELONGATION%REACTOME%R-RNO-69190.1 DNA strand elongation INTERFERON ALPHA BETA SIGNALING%REACTOME%R-RNO-909733.1 Interferon alpha beta signaling TOLL-LIKE RECEPTOR CASCADES%REACTOME DATABASE ID RELEASE 66%10145131 Toll-like Receptor Cascades RESOLUTION OF SISTER CHROMATID COHESION%REACTOME DATABASE ID RELEASE 66%10145894 Resolution of Sister Chromatid Cohesion GPVI-MEDIATED ACTIVATION CASCADE%REACTOME%R-RNO-114604.1 GPVI-mediated activation cascade NADE MODULATES DEATH SIGNALLING%REACTOME DATABASE ID RELEASE 66%10145330 NADE modulates death signalling RHO GTPASES ACTIVATE RHOTEKIN AND RHOPHILINS%REACTOME DATABASE ID RELEASE 66%10146121 RHO GTPases Activate Rhotekin and Rhophilins PROSTANOID LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145568 Prostanoid ligand receptors PACKAGING OF TELOMERE ENDS%REACTOME%R-RNO-171306.1 Packaging Of Telomere Ends ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING%REACTOME DATABASE ID RELEASE 66%10145740 Advanced glycosylation endproduct receptor signaling TP53 REGULATES TRANSCRIPTION OF CELL DEATH GENES%REACTOME%R-RNO-5633008.1 TP53 Regulates Transcription of Cell Death Genes FGFR2C LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 66%10145288 FGFR2c ligand binding and activation PLASMA LIPOPROTEIN ASSEMBLY%REACTOME%R-RNO-8963898.1 Plasma lipoprotein assembly ACTIVATED NTRK2 SIGNALS THROUGH FRS2 AND FRS3%REACTOME%R-RNO-9028731.1 Activated NTRK2 signals through FRS2 and FRS3 E2F MEDIATED REGULATION OF DNA REPLICATION%REACTOME DATABASE ID RELEASE 66%10145014 E2F mediated regulation of DNA replication TOLL LIKE RECEPTOR 2 (TLR2) CASCADE%REACTOME%R-RNO-181438.1 Toll Like Receptor 2 (TLR2) Cascade TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION%REACTOME%R-RNO-1474151.1 Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation RHO GTPASES ACTIVATE NADPH OXIDASES%REACTOME DATABASE ID RELEASE 66%10146047 RHO GTPases Activate NADPH Oxidases DOWNREGULATION OF ERBB2:ERBB3 SIGNALING%REACTOME%R-RNO-1358803.1 Downregulation of ERBB2:ERBB3 signaling CELL-CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 66%10145495 Cell-cell junction organization SYNTHESIS OF IPS IN THE NUCLEUS%REACTOME%R-RNO-1855191.1 Synthesis of IPs in the nucleus SYNTHESIS OF DNA%REACTOME DATABASE ID RELEASE 66%10144719 Synthesis of DNA SYNTHESIS OF BILE ACIDS AND BILE SALTS%REACTOME DATABASE ID RELEASE 66%10145312 Synthesis of bile acids and bile salts APOPTOTIC FACTOR-MEDIATED RESPONSE%REACTOME%R-RNO-111471.1 Apoptotic factor-mediated response GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT%REACTOME%R-RNO-72706.1 GTP hydrolysis and joining of the 60S ribosomal subunit INTRA-GOLGI AND RETROGRADE GOLGI-TO-ER TRAFFIC%REACTOME DATABASE ID RELEASE 66%10146192 Intra-Golgi and retrograde Golgi-to-ER traffic SIGNALING BY RECEPTOR TYROSINE KINASES%REACTOME DATABASE ID RELEASE 66%10144877 Signaling by Receptor Tyrosine Kinases TRANS-GOLGI NETWORK VESICLE BUDDING%REACTOME DATABASE ID RELEASE 66%10145468 trans-Golgi Network Vesicle Budding LIGAND-INDEPENDENT CASPASE ACTIVATION VIA DCC%REACTOME DATABASE ID RELEASE 66%10145489 Ligand-independent caspase activation via DCC IONOTROPIC ACTIVITY OF KAINATE RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145699 Ionotropic activity of kainate receptors SMAC-MEDIATED DISSOCIATION OF IAP:CASPASE COMPLEXES%REACTOME%R-RNO-111464.1 SMAC-mediated dissociation of IAP:caspase complexes MITOTIC G1-G1 S PHASES%REACTOME DATABASE ID RELEASE 66%10144725 Mitotic G1-G1 S phases HEME DEGRADATION%REACTOME%R-RNO-189483.1 Heme degradation BIOSYNTHESIS OF DPAN-3-DERIVED MARESINS%REACTOME%R-RNO-9026290.1 Biosynthesis of DPAn-3-derived maresins TP53 REGULATES TRANSCRIPTION OF ADDITIONAL CELL CYCLE GENES WHOSE EXACT ROLE IN THE P53 PATHWAY REMAIN UNCERTAIN%REACTOME%R-RNO-6804115.1 TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain FGFR3 LIGAND BINDING AND ACTIVATION%REACTOME%R-RNO-190239.1 FGFR3 ligand binding and activation MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 66%10145043 Muscle contraction DEATH RECEPTOR SIGNALLING%REACTOME DATABASE ID RELEASE 66%10144808 Death Receptor Signalling DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR)%REACTOME DATABASE ID RELEASE 66%10145798 Downstream signaling events of B Cell Receptor (BCR) TNFR1-INDUCED PROAPOPTOTIC SIGNALING%REACTOME DATABASE ID RELEASE 66%10144945 TNFR1-induced proapoptotic signaling KSRP (KHSRP) BINDS AND DESTABILIZES MRNA%REACTOME DATABASE ID RELEASE 66%10145696 KSRP (KHSRP) binds and destabilizes mRNA BIOSYNTHESIS OF PROTECTINS%REACTOME%R-RNO-9018681.1 Biosynthesis of protectins SIGNALING BY ERYTHROPOIETIN%REACTOME DATABASE ID RELEASE 66%10146295 Signaling by Erythropoietin DISINHIBITION OF SNARE FORMATION%REACTOME DATABASE ID RELEASE 66%10145035 Disinhibition of SNARE formation CATECHOLAMINE BIOSYNTHESIS%REACTOME%R-RNO-209905.1 Catecholamine biosynthesis TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES%REACTOME%R-RNO-425393.1 Transport of inorganic cations anions and amino acids oligopeptides SIGNAL ATTENUATION%REACTOME%R-RNO-74749.1 Signal attenuation NONHOMOLOGOUS END-JOINING (NHEJ)%REACTOME%R-RNO-5693571.1 Nonhomologous End-Joining (NHEJ) BASIGIN INTERACTIONS%REACTOME%R-RNO-210991.1 Basigin interactions SUMO IS CONJUGATED TO E1 (UBA2:SAE1)%REACTOME DATABASE ID RELEASE 66%10145983 SUMO is conjugated to E1 (UBA2:SAE1) NUCLEAR SIGNALING BY ERBB4%REACTOME%R-RNO-1251985.1 Nuclear signaling by ERBB4 LIPOPROTEIN METABOLISM%REACTOME DATABASE ID RELEASE 66%10145205 Lipoprotein metabolism CA ACTIVATED K+ CHANNELS%REACTOME DATABASE ID RELEASE 66%10145832 Ca activated K+ channels SYNTHESIS OF IPS IN THE ER LUMEN%REACTOME%R-RNO-1855231.1 Synthesis of IPs in the ER lumen LEUKOTRIENE RECEPTORS%REACTOME%R-RNO-391906.1 Leukotriene receptors CELL JUNCTION ORGANIZATION%REACTOME%R-RNO-446728.1 Cell junction organization PHOSPHORYLATION OF THE APC C%REACTOME DATABASE ID RELEASE 66%10145220 Phosphorylation of the APC C ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY%REACTOME DATABASE ID RELEASE 66%10145655 Zinc influx into cells by the SLC39 gene family P75 NTR RECEPTOR-MEDIATED SIGNALLING%REACTOME%R-RNO-193704.1 p75 NTR receptor-mediated signalling METABOLISM%REACTOME DATABASE ID RELEASE 66%10144767 Metabolism XBP1(S) ACTIVATES CHAPERONE GENES%REACTOME%R-RNO-381038.1 XBP1(S) activates chaperone genes COPI-MEDIATED ANTEROGRADE TRANSPORT%REACTOME%R-RNO-6807878.1 COPI-mediated anterograde transport INTERLEUKIN-12 SIGNALING%REACTOME DATABASE ID RELEASE 66%10145676 Interleukin-12 signaling NONSENSE-MEDIATED DECAY (NMD)%REACTOME%R-RNO-927802.1 Nonsense-Mediated Decay (NMD) REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE%REACTOME%R-RNO-3371453.1 Regulation of HSF1-mediated heat shock response TRANSCRIPTIONAL REGULATION BY TP53%REACTOME DATABASE ID RELEASE 66%10144748 Transcriptional Regulation by TP53 ROBO RECEPTORS BIND AKAP5%REACTOME%R-RNO-9010642.1 ROBO receptors bind AKAP5 INTERLEUKIN-35 SIGNALLING%REACTOME DATABASE ID RELEASE 66%10145680 Interleukin-35 Signalling TRANSLATION%REACTOME%R-RNO-72766.1 Translation TP53 REGULATES TRANSCRIPTION OF CASPASE ACTIVATORS AND CASPASES%REACTOME%R-RNO-6803207.1 TP53 Regulates Transcription of Caspase Activators and Caspases VISUAL PHOTOTRANSDUCTION%REACTOME%R-RNO-2187338.1 Visual phototransduction ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS%REACTOME DATABASE ID RELEASE 66%10145358 Role of phospholipids in phagocytosis TRAF6-MEDIATED INDUCTION OF TAK1 COMPLEX WITHIN TLR4 COMPLEX%REACTOME DATABASE ID RELEASE 66%10145767 TRAF6-mediated induction of TAK1 complex within TLR4 complex TRKA ACTIVATION BY NGF%REACTOME DATABASE ID RELEASE 66%10145140 TRKA activation by NGF AQUAPORIN-MEDIATED TRANSPORT%REACTOME DATABASE ID RELEASE 66%10145007 Aquaporin-mediated transport CHK1 CHK2(CDS1) MEDIATED INACTIVATION OF CYCLIN B:CDK1 COMPLEX%REACTOME%R-RNO-75035.1 Chk1 Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex NEURONAL SYSTEM%REACTOME DATABASE ID RELEASE 66%10144791 Neuronal System SIGNAL REGULATORY PROTEIN FAMILY INTERACTIONS%REACTOME DATABASE ID RELEASE 66%10145430 Signal regulatory protein family interactions RHO GTPASES ACTIVATE ROCKS%REACTOME%R-RNO-5627117.1 RHO GTPases Activate ROCKs TRIF(TICAM1)-MEDIATED TLR4 SIGNALING%REACTOME DATABASE ID RELEASE 66%10145138 TRIF(TICAM1)-mediated TLR4 signaling REGULATION OF TP53 DEGRADATION%REACTOME DATABASE ID RELEASE 66%10145361 Regulation of TP53 Degradation VITAMIN B1 (THIAMIN) METABOLISM%REACTOME%R-RNO-196819.1 Vitamin B1 (thiamin) metabolism E3 UBIQUITIN LIGASES UBIQUITINATE TARGET PROTEINS%REACTOME%R-RNO-8866654.1 E3 ubiquitin ligases ubiquitinate target proteins RESOLUTION OF D-LOOP STRUCTURES THROUGH SYNTHESIS-DEPENDENT STRAND ANNEALING (SDSA)%REACTOME DATABASE ID RELEASE 66%10146147 Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) TWIK RELATED POTASSIUM CHANNEL (TREK)%REACTOME DATABASE ID RELEASE 66%10145838 TWIK related potassium channel (TREK) REGULATION OF BETA-CELL DEVELOPMENT%REACTOME DATABASE ID RELEASE 66%10145438 Regulation of beta-cell development PROCESSIVE SYNTHESIS ON THE LAGGING STRAND%REACTOME%R-RNO-69183.1 Processive synthesis on the lagging strand CARBOXYTERMINAL POST-TRANSLATIONAL MODIFICATIONS OF TUBULIN%REACTOME%R-RNO-8955332.1 Carboxyterminal post-translational modifications of tubulin APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME DATABASE ID RELEASE 66%10145218 APC C:Cdc20 mediated degradation of mitotic proteins DEGRADATION OF AXIN%REACTOME DATABASE ID RELEASE 66%10146020 Degradation of AXIN DNA DAMAGE BYPASS%REACTOME DATABASE ID RELEASE 66%10144978 DNA Damage Bypass SIGNALING BY ACTIVIN%REACTOME%R-RNO-1502540.1 Signaling by Activin CELL DIVISION%REACTOME%R-RNO-68884.1 cell division OAS ANTIVIRAL RESPONSE%REACTOME DATABASE ID RELEASE 66%10146284 OAS antiviral response PKA-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%R-RNO-111931.1 PKA-mediated phosphorylation of CREB RHO GTPASES ACTIVATE WASPS AND WAVES%REACTOME DATABASE ID RELEASE 66%10145928 RHO GTPases Activate WASPs and WAVEs SNRNP ASSEMBLY%REACTOME%R-RNO-191859.1 snRNP Assembly CHROMOSOME MAINTENANCE%REACTOME DATABASE ID RELEASE 66%10145113 Chromosome Maintenance TRANSCRIPTIONAL REGULATION BY RUNX1%REACTOME DATABASE ID RELEASE 66%10146236 Transcriptional regulation by RUNX1 AFLATOXIN ACTIVATION AND DETOXIFICATION%REACTOME DATABASE ID RELEASE 66%10145070 Aflatoxin activation and detoxification SEROTONIN AND MELATONIN BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 66%10145426 Serotonin and melatonin biosynthesis N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI%REACTOME%R-RNO-975576.1 N-glycan antennae elongation in the medial trans-Golgi HYDROLYSIS OF LPE%REACTOME%R-RNO-1483152.1 Hydrolysis of LPE ACTIVATED NTRK3 SIGNALS THROUGH PI3K%REACTOME%R-RNO-9603381.1 Activated NTRK3 signals through PI3K SIGNAL TRANSDUCTION BY L1%REACTOME%R-RNO-445144.1 Signal transduction by L1 PDE3B SIGNALLING%REACTOME%R-RNO-165160.1 PDE3B signalling IRS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 66%10144880 IRS-mediated signalling TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE%REACTOME DATABASE ID RELEASE 66%10145154 Toll Like Receptor 7 8 (TLR7 8) Cascade ATP SENSITIVE POTASSIUM CHANNELS%REACTOME DATABASE ID RELEASE 66%10145831 ATP sensitive Potassium channels COOPERATION OF PDCL (PHLP1) AND TRIC CCT IN G-PROTEIN BETA FOLDING%REACTOME DATABASE ID RELEASE 66%10146196 Cooperation of PDCL (PhLP1) and TRiC CCT in G-protein beta folding NRIF SIGNALS CELL DEATH FROM THE NUCLEUS%REACTOME DATABASE ID RELEASE 66%10145334 NRIF signals cell death from the nucleus CD209 (DC-SIGN) SIGNALING%REACTOME%R-RNO-5621575.1 CD209 (DC-SIGN) signaling ANTIMICROBIAL PEPTIDES%REACTOME%R-RNO-6803157.1 Antimicrobial peptides VITAMIN C (ASCORBATE) METABOLISM%REACTOME DATABASE ID RELEASE 66%10145368 Vitamin C (ascorbate) metabolism DEUBIQUITINATION%REACTOME DATABASE ID RELEASE 66%10145726 Deubiquitination AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS%REACTOME DATABASE ID RELEASE 66%10145371 AKT phosphorylates targets in the nucleus INFLAMMASOMES%REACTOME DATABASE ID RELEASE 66%10145733 Inflammasomes PROCESSING OF SMDT1%REACTOME%R-RNO-8949664.1 Processing of SMDT1 COPII-MEDIATED VESICLE TRANSPORT%REACTOME%R-RNO-204005.1 COPII-mediated vesicle transport IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME DATABASE ID RELEASE 66%10145773 IRAK2 mediated activation of TAK1 complex upon TLR7 8 or 9 stimulation BIOSYNTHESIS OF DPAN-3 SPMS%REACTOME%R-RNO-9025094.1 Biosynthesis of DPAn-3 SPMs SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS%REACTOME DATABASE ID RELEASE 66%10144939 SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE%REACTOME%R-RNO-4641262.1 Disassembly of the destruction complex and recruitment of AXIN to the membrane COLLAGEN DEGRADATION%REACTOME DATABASE ID RELEASE 66%10145855 Collagen degradation PROTEIN REPAIR%REACTOME%R-RNO-5676934.1 Protein repair ACROSOME REACTION%REACTOME%R-RNO-1300645.1 Acrosome Reaction PKA ACTIVATION%REACTOME%R-RNO-163615.1 PKA activation PROCESSING OF INTRONLESS PRE-MRNAS%REACTOME DATABASE ID RELEASE 66%10144941 Processing of Intronless Pre-mRNAs NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 66%10145491 Netrin-1 signaling FMO OXIDISES NUCLEOPHILES%REACTOME%R-RNO-217271.1 FMO oxidises nucleophiles ASTROCYTIC GLUTAMATE-GLUTAMINE UPTAKE AND METABOLISM%REACTOME%R-RNO-210455.1 Astrocytic Glutamate-Glutamine Uptake And Metabolism RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES%REACTOME%R-RNO-380270.1 Recruitment of mitotic centrosome proteins and complexes METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS%REACTOME%R-RNO-196849.1 Metabolism of water-soluble vitamins and cofactors CELLULAR RESPONSE TO HYPOXIA%REACTOME%R-RNO-2262749.1 Cellular response to hypoxia PHOSPHOLIPASE C-MEDIATED CASCADE; FGFR4%REACTOME DATABASE ID RELEASE 66%10146101 Phospholipase C-mediated cascade; FGFR4 CROSSLINKING OF COLLAGEN FIBRILS%REACTOME DATABASE ID RELEASE 66%10145923 Crosslinking of collagen fibrils CELL SURFACE INTERACTIONS AT THE VASCULAR WALL%REACTOME DATABASE ID RELEASE 66%10145033 Cell surface interactions at the vascular wall FORMATION OF THE EDITOSOME%REACTOME DATABASE ID RELEASE 66%10144942 Formation of the Editosome ACTIVATION OF NOXA AND TRANSLOCATION TO MITOCHONDRIA%REACTOME DATABASE ID RELEASE 66%10145050 Activation of NOXA and translocation to mitochondria REGULATION OF THYROID HORMONE ACTIVITY%REACTOME DATABASE ID RELEASE 66%10145423 Regulation of thyroid hormone activity SODIUM-COUPLED SULPHATE, DI- AND TRI-CARBOXYLATE TRANSPORTERS%REACTOME DATABASE ID RELEASE 66%10145648 Sodium-coupled sulphate, di- and tri-carboxylate transporters APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1%REACTOME%R-RNO-174178.1 APC C:Cdh1 mediated degradation of Cdc20 and other APC C:Cdh1 targeted proteins in late mitosis early G1 BIOSYNTHESIS OF DPAN-3-DERIVED 13-SERIES RESOLVINS%REACTOME%R-RNO-9026403.1 Biosynthesis of DPAn-3-derived 13-series resolvins TP53 REGULATES TRANSCRIPTION OF DEATH RECEPTORS AND LIGANDS%REACTOME%R-RNO-6803211.1 TP53 Regulates Transcription of Death Receptors and Ligands O2 CO2 EXCHANGE IN ERYTHROCYTES%REACTOME DATABASE ID RELEASE 66%10145818 O2 CO2 exchange in erythrocytes FGFR2B LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 66%10145290 FGFR2b ligand binding and activation RAF ACTIVATION%REACTOME DATABASE ID RELEASE 66%10146124 RAF activation ARMS-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 66%10145180 ARMS-mediated activation GRB2 EVENTS IN EGFR SIGNALING%REACTOME%R-RNO-179812.1 GRB2 events in EGFR signaling HS-GAG BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 66%10145730 HS-GAG biosynthesis STAT6-MEDIATED INDUCTION OF CHEMOKINES%REACTOME%R-RNO-3249367.1 STAT6-mediated induction of chemokines DEGRADATION OF GABA%REACTOME DATABASE ID RELEASE 66%10145745 Degradation of GABA BIOSYNTHESIS OF E-SERIES 18(R)-RESOLVINS%REACTOME DATABASE ID RELEASE 66%10146300 Biosynthesis of E-series 18(R)-resolvins DNA DOUBLE STRAND BREAK RESPONSE%REACTOME%R-RNO-5693606.1 DNA Double Strand Break Response REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN%REACTOME DATABASE ID RELEASE 66%10145192 Regulation of Glucokinase by Glucokinase Regulatory Protein CYTOSOLIC SULFONATION OF SMALL MOLECULES%REACTOME%R-RNO-156584.1 Cytosolic sulfonation of small molecules CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS%REACTOME%R-RNO-264870.1 Caspase-mediated cleavage of cytoskeletal proteins DISPLACEMENT OF DNA GLYCOSYLASE BY APEX1%REACTOME%R-RNO-110357.1 Displacement of DNA glycosylase by APEX1 NICOTINAMIDE SALVAGING%REACTOME%R-RNO-197264.1 Nicotinamide salvaging TELOMERE MAINTENANCE%REACTOME DATABASE ID RELEASE 66%10145112 Telomere Maintenance RECYCLING OF EIF2:GDP%REACTOME%R-RNO-72731.1 Recycling of eIF2:GDP CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE%REACTOME DATABASE ID RELEASE 66%10144920 Cytochrome P450 - arranged by substrate type UB-SPECIFIC PROCESSING PROTEASES%REACTOME%R-RNO-5689880.1 Ub-specific processing proteases O-GLYCOSYLATION OF TSR DOMAIN-CONTAINING PROTEINS%REACTOME DATABASE ID RELEASE 66%10146044 O-glycosylation of TSR domain-containing proteins TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT%REACTOME DATABASE ID RELEASE 66%10144895 Transport of Mature mRNA derived from an Intron-Containing Transcript MET ACTIVATES PI3K AKT SIGNALING%REACTOME%R-RNO-8851907.1 MET activates PI3K AKT signaling NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME DATABASE ID RELEASE 66%10145957 NOTCH2 intracellular domain regulates transcription RET SIGNALING%REACTOME DATABASE ID RELEASE 66%10146221 RET signaling CLATHRIN-MEDIATED ENDOCYTOSIS%REACTOME DATABASE ID RELEASE 66%10146228 Clathrin-mediated endocytosis FGFR2 ALTERNATIVE SPLICING%REACTOME%R-RNO-6803529.1 FGFR2 alternative splicing NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME DATABASE ID RELEASE 66%10145624 Negative epigenetic regulation of rRNA expression C-TYPE LECTIN RECEPTORS (CLRS)%REACTOME%R-RNO-5621481.1 C-type lectin receptors (CLRs) TRANSPORT OF CONNEXINS ALONG THE SECRETORY PATHWAY%REACTOME DATABASE ID RELEASE 66%215126 Transport of connexins along the secretory pathway BICARBONATE TRANSPORTERS%REACTOME DATABASE ID RELEASE 66%10145616 Bicarbonate transporters HEMOSTASIS%REACTOME DATABASE ID RELEASE 66%10145028 Hemostasis BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS%REACTOME%R-RNO-111453.1 BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members POSITIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%R-RNO-5250913.1 Positive epigenetic regulation of rRNA expression DEGRADATION OF CYSTEINE AND HOMOCYSTEINE%REACTOME DATABASE ID RELEASE 66%10145890 Degradation of cysteine and homocysteine TRANSPORT OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 66%10144953 Transport of small molecules INTERLEUKIN-1 PROCESSING%REACTOME%R-RNO-448706.1 Interleukin-1 processing FC EPSILON RECEPTOR (FCERI) SIGNALING%REACTOME DATABASE ID RELEASE 66%10145167 Fc epsilon receptor (FCERI) signaling SEROTONIN RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145563 Serotonin receptors REVERSAL OF ALKYLATION DAMAGE BY DNA DIOXYGENASES%REACTOME DATABASE ID RELEASE 66%10146230 Reversal of alkylation damage by DNA dioxygenases PROTEIN-PROTEIN INTERACTIONS AT SYNAPSES%REACTOME%R-RNO-6794362.1 Protein-protein interactions at synapses MET PROMOTES CELL MOTILITY%REACTOME DATABASE ID RELEASE 66%10146247 MET promotes cell motility MRNA EDITING: C TO U CONVERSION%REACTOME%R-RNO-72200.1 mRNA Editing: C to U Conversion ECM PROTEOGLYCANS%REACTOME%R-RNO-3000178.1 ECM proteoglycans P38MAPK EVENTS%REACTOME DATABASE ID RELEASE 66%10145201 p38MAPK events INNATE IMMUNE SYSTEM%REACTOME%R-RNO-168249.1 Innate Immune System TRANSMISSION ACROSS ELECTRICAL SYNAPSES%REACTOME DATABASE ID RELEASE 66%10145508 Transmission across Electrical Synapses EPHA-MEDIATED GROWTH CONE COLLAPSE%REACTOME DATABASE ID RELEASE 66%10146028 EPHA-mediated growth cone collapse IRF3 MEDIATED ACTIVATION OF TYPE 1 IFN%REACTOME%R-RNO-1606341.1 IRF3 mediated activation of type 1 IFN HDL REMODELING%REACTOME DATABASE ID RELEASE 66%10145453 HDL remodeling SIGNALING BY GPCR%REACTOME DATABASE ID RELEASE 66%10144870 Signaling by GPCR ELASTIC FIBRE FORMATION%REACTOME%R-RNO-1566948.1 Elastic fibre formation FGFR4 LIGAND BINDING AND ACTIVATION%REACTOME%R-RNO-190322.1 FGFR4 ligand binding and activation INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION%REACTOME%R-RNO-400508.1 Incretin synthesis, secretion, and inactivation METALLOTHIONEINS BIND METALS%REACTOME%R-RNO-5661231.1 Metallothioneins bind metals INSULIN PROCESSING%REACTOME DATABASE ID RELEASE 66%10145456 Insulin processing ANCHORING FIBRIL FORMATION%REACTOME%R-RNO-2214320.1 Anchoring fibril formation MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF UNSATURATED FATTY ACIDS%REACTOME DATABASE ID RELEASE 66%10144949 mitochondrial fatty acid beta-oxidation of unsaturated fatty acids SCAVENGING BY CLASS A RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145956 Scavenging by Class A Receptors CLATHRIN DERIVED VESICLE BUDDING%REACTOME%R-RNO-421837.1 Clathrin derived vesicle budding SCAVENGING BY CLASS H RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145959 Scavenging by Class H Receptors POLB-DEPENDENT LONG PATCH BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 66%10146093 POLB-Dependent Long Patch Base Excision Repair MACROAUTOPHAGY%REACTOME%R-RNO-1632852.1 Macroautophagy GOLGI ASSOCIATED VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 66%10145614 Golgi Associated Vesicle Biogenesis HEDGEHOG LIGAND BIOGENESIS%REACTOME%R-RNO-5358346.1 Hedgehog ligand biogenesis SIGNALING BY NTRK3 (TRKC)%REACTOME DATABASE ID RELEASE 66%10146326 Signaling by NTRK3 (TRKC) SIGNALING BY NTRK2 (TRKB)%REACTOME DATABASE ID RELEASE 66%10146316 Signaling by NTRK2 (TRKB) NEGATIVE REGULATION OF NOTCH4 SIGNALING%REACTOME DATABASE ID RELEASE 66%10146331 Negative regulation of NOTCH4 signaling ERBB2 ACTIVATES PTK6 SIGNALING%REACTOME%R-RNO-8847993.1 ERBB2 Activates PTK6 Signaling WNT MEDIATED ACTIVATION OF DVL%REACTOME DATABASE ID RELEASE 66%10145393 WNT mediated activation of DVL DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY%REACTOME%R-RNO-2173795.1 Downregulation of SMAD2 3:SMAD4 transcriptional activity REGULATION OF IGF ACTIVITY BY IGFBP%REACTOME%R-RNO-381426.1 Regulation of IGF Activity by IGFBP EUKARYOTIC TRANSLATION TERMINATION%REACTOME DATABASE ID RELEASE 66%10146146 Eukaryotic Translation Termination ACTIVATED NTRK3 SIGNALS THROUGH PLCG1%REACTOME DATABASE ID RELEASE 66%10146327 Activated NTRK3 signals through PLCG1 THE NLRP1 INFLAMMASOME%REACTOME DATABASE ID RELEASE 66%10145732 The NLRP1 inflammasome SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP)%REACTOME%R-RNO-400511.1 Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER%REACTOME%R-RNO-76061.1 RNA Polymerase III Transcription Initiation From Type 1 Promoter TRANSCRIPTIONAL REGULATION BY MECP2%REACTOME%R-RNO-8986944.1 Transcriptional Regulation by MECP2 MITOCHONDRIAL TRANSLATION%REACTOME%R-RNO-5368287.1 Mitochondrial translation PROTEIN LOCALIZATION%REACTOME DATABASE ID RELEASE 66%10146283 Protein localization CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX%REACTOME%R-RNO-68689.1 CDC6 association with the ORC:origin complex RESOLUTION OF D-LOOP STRUCTURES%REACTOME%R-RNO-5693537.1 Resolution of D-Loop Structures SPHINGOLIPID DE NOVO BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 66%10145630 Sphingolipid de novo biosynthesis CLEARANCE OF DOPAMINE%REACTOME%R-RNO-379401.1 Clearance of dopamine GABA SYNTHESIS%REACTOME DATABASE ID RELEASE 66%10145746 GABA synthesis SUMOYLATION OF TRANSCRIPTION COFACTORS%REACTOME DATABASE ID RELEASE 66%10145995 SUMOylation of transcription cofactors SIGNALING BY WNT%REACTOME DATABASE ID RELEASE 66%10145342 Signaling by WNT ESTROGEN BIOSYNTHESIS%REACTOME%R-RNO-193144.1 Estrogen biosynthesis SUMOYLATION OF CHROMATIN ORGANIZATION PROTEINS%REACTOME%R-RNO-4551638.1 SUMOylation of chromatin organization proteins CLEAVAGE OF THE DAMAGED PURINE%REACTOME DATABASE ID RELEASE 66%10144974 Cleavage of the damaged purine DEPOLYMERISATION OF THE NUCLEAR LAMINA%REACTOME DATABASE ID RELEASE 66%10146031 Depolymerisation of the Nuclear Lamina EPIGENETIC REGULATION OF GENE EXPRESSION%REACTOME DATABASE ID RELEASE 66%10145445 Epigenetic regulation of gene expression REACTIONS SPECIFIC TO THE HYBRID N-GLYCAN SYNTHESIS PATHWAY%REACTOME%R-RNO-975574.1 Reactions specific to the hybrid N-glycan synthesis pathway RHO GTPASES ACTIVATE PAKS%REACTOME%R-RNO-5627123.1 RHO GTPases activate PAKs DEGRADATION OF DVL%REACTOME DATABASE ID RELEASE 66%10145877 Degradation of DVL TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS%REACTOME DATABASE ID RELEASE 66%10145193 TGF-beta receptor signaling activates SMADs PYRUVATE METABOLISM%REACTOME%R-RNO-70268.1 Pyruvate metabolism PLATELET ACTIVATION, SIGNALING AND AGGREGATION%REACTOME DATABASE ID RELEASE 66%10145027 Platelet activation, signaling and aggregation LOSS OF NLP FROM MITOTIC CENTROSOMES%REACTOME%R-RNO-380259.1 Loss of Nlp from mitotic centrosomes CAM PATHWAY%REACTOME DATABASE ID RELEASE 66%10144992 CaM pathway SIGNALING BY SCF-KIT%REACTOME DATABASE ID RELEASE 66%10145420 Signaling by SCF-KIT TIGHT JUNCTION INTERACTIONS%REACTOME%R-RNO-420029.1 Tight junction interactions NUCLEOTIDE METABOLISM%REACTOME DATABASE ID RELEASE 66%10144816 Nucleotide metabolism INHIBITION OF ADENYLATE CYCLASE PATHWAY%REACTOME%R-RNO-997269.1 Inhibition of adenylate cyclase pathway RNA POLYMERASE II TRANSCRIBES SNRNA GENES%REACTOME DATABASE ID RELEASE 66%10146187 RNA polymerase II transcribes snRNA genes MRNA DECAY BY 3' TO 5' EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 66%10145639 mRNA decay by 3' to 5' exoribonuclease AMINE-DERIVED HORMONES%REACTOME%R-RNO-209776.1 Amine-derived hormones PROGRESSIVE TRIMMING OF ALPHA-1,2-LINKED MANNOSE RESIDUES FROM MAN9 8 7GLCNAC2 TO PRODUCE MAN5GLCNAC2%REACTOME%R-RNO-964827.1 Progressive trimming of alpha-1,2-linked mannose residues from Man9 8 7GlcNAc2 to produce Man5GlcNAc2 AMINO ACID AND DERIVATIVE METABOLISM%REACTOME%R-RNO-71291.1 Amino acid and derivative metabolism INOSITOL PHOSPHATE METABOLISM%REACTOME%R-RNO-1483249.1 Inositol phosphate metabolism FORMATION OF ATP BY CHEMIOSMOTIC COUPLING%REACTOME DATABASE ID RELEASE 66%10145126 Formation of ATP by chemiosmotic coupling ACTIVATION OF SMO%REACTOME DATABASE ID RELEASE 66%10146091 Activation of SMO GLI3 IS PROCESSED TO GLI3R BY THE PROTEASOME%REACTOME DATABASE ID RELEASE 66%10146075 GLI3 is processed to GLI3R by the proteasome RELEASE OF HH-NP FROM THE SECRETING CELL%REACTOME DATABASE ID RELEASE 66%10146062 Release of Hh-Np from the secreting cell ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES%REACTOME%R-RNO-2022090.1 Assembly of collagen fibrils and other multimeric structures PEROXISOMAL PROTEIN IMPORT%REACTOME DATABASE ID RELEASE 66%10146282 Peroxisomal protein import RECYCLING PATHWAY OF L1%REACTOME DATABASE ID RELEASE 66%10145501 Recycling pathway of L1 VASOPRESSIN REGULATES RENAL WATER HOMEOSTASIS VIA AQUAPORINS%REACTOME%R-RNO-432040.1 Vasopressin regulates renal water homeostasis via Aquaporins PI5P REGULATES TP53 ACETYLATION%REACTOME%R-RNO-6811555.1 PI5P Regulates TP53 Acetylation HYPUSINYLATION%REACTOME%R-RNO-204626.1 Hypusinylation UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1%REACTOME DATABASE ID RELEASE 66%10144899 Ubiquitin-dependent degradation of Cyclin D1 VEGFA-VEGFR2 PATHWAY%REACTOME DATABASE ID RELEASE 66%10145272 VEGFA-VEGFR2 Pathway TRANSCRIPTIONAL REGULATION BY RUNX3%REACTOME%R-RNO-8878159.1 Transcriptional regulation by RUNX3 TP53 REGULATES TRANSCRIPTION OF DNA REPAIR GENES%REACTOME DATABASE ID RELEASE 66%10146165 TP53 Regulates Transcription of DNA Repair Genes PI-3K CASCADE:FGFR2%REACTOME DATABASE ID RELEASE 66%10145254 PI-3K cascade:FGFR2 TRANSLESION SYNTHESIS BY REV1%REACTOME DATABASE ID RELEASE 66%10144976 Translesion synthesis by REV1 SHC1 EVENTS IN ERBB4 SIGNALING%REACTOME DATABASE ID RELEASE 66%10145825 SHC1 events in ERBB4 signaling TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM%REACTOME DATABASE ID RELEASE 66%10144896 Transport of Mature Transcript to Cytoplasm CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 66%10144717 CDT1 association with the CDC6:ORC:origin complex ACTIVATION OF BMF AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%R-RNO-139910.1 Activation of BMF and translocation to mitochondria CELL CYCLE, MITOTIC%REACTOME DATABASE ID RELEASE 66%10144721 Cell Cycle, Mitotic NEGATIVE REGULATION OF MET ACTIVITY%REACTOME%R-RNO-6807004.1 Negative regulation of MET activity MTOR SIGNALLING%REACTOME DATABASE ID RELEASE 66%10145128 mTOR signalling PURINE CATABOLISM%REACTOME%R-RNO-74259.1 Purine catabolism PHENYLALANINE AND TYROSINE CATABOLISM%REACTOME%R-RNO-71182.1 Phenylalanine and tyrosine catabolism SYNTHESIS OF DIPHTHAMIDE-EEF2%REACTOME DATABASE ID RELEASE 66%10146058 Synthesis of diphthamide-EEF2 TRIGLYCERIDE CATABOLISM%REACTOME%R-RNO-163560.1 Triglyceride catabolism CD28 CO-STIMULATION%REACTOME DATABASE ID RELEASE 66%10145354 CD28 co-stimulation REMOVAL OF AMINOTERMINAL PROPEPTIDES FROM GAMMA-CARBOXYLATED PROTEINS%REACTOME%R-RNO-159782.1 Removal of aminoterminal propeptides from gamma-carboxylated proteins EGFR TRANSACTIVATION BY GASTRIN%REACTOME%R-RNO-2179392.1 EGFR Transactivation by Gastrin GENE SILENCING BY RNA%REACTOME DATABASE ID RELEASE 66%10145435 Gene Silencing by RNA RUNX1 REGULATES GENES INVOLVED IN MEGAKARYOCYTE DIFFERENTIATION AND PLATELET FUNCTION%REACTOME%R-RNO-8936459.1 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function ONCOGENE INDUCED SENESCENCE%REACTOME DATABASE ID RELEASE 66%10145265 Oncogene Induced Senescence BIOSYNTHESIS OF MARESIN CONJUGATES IN TISSUE REGENERATION (MCTR)%REACTOME DATABASE ID RELEASE 66%10146313 Biosynthesis of maresin conjugates in tissue regeneration (MCTR) ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS%REACTOME DATABASE ID RELEASE 66%10145721 Acetylcholine binding and downstream events LIPID PARTICLE ORGANIZATION%REACTOME%R-RNO-8964572.1 Lipid particle organization TYPE I HEMIDESMOSOME ASSEMBLY%REACTOME DATABASE ID RELEASE 66%10145647 Type I hemidesmosome assembly METABOLISM OF INGESTED MESEO2H INTO MESEH%REACTOME%R-RNO-5263617.1 Metabolism of ingested MeSeO2H into MeSeH PROTEIN METHYLATION%REACTOME%R-RNO-8876725.1 Protein methylation SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE%REACTOME DATABASE ID RELEASE 66%10145901 Synthesis of PIPs at the Golgi membrane LAMININ INTERACTIONS%REACTOME DATABASE ID RELEASE 66%10145448 Laminin interactions SMAC BINDS TO IAPS%REACTOME%R-RNO-111463.1 SMAC binds to IAPs NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING%REACTOME%R-RNO-936440.1 Negative regulators of RIG-I MDA5 signaling HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM%REACTOME DATABASE ID RELEASE 66%10145731 Heparan sulfate heparin (HS-GAG) metabolism APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS%REACTOME DATABASE ID RELEASE 66%10145386 Apoptotic cleavage of cell adhesion proteins ASPARAGINE N-LINKED GLYCOSYLATION%REACTOME%R-RNO-446203.1 Asparagine N-linked glycosylation FORMATION OF FIBRIN CLOT (CLOTTING CASCADE)%REACTOME%R-RNO-140877.1 Formation of Fibrin Clot (Clotting Cascade) CD28 DEPENDENT PI3K AKT SIGNALING%REACTOME%R-RNO-389357.1 CD28 dependent PI3K Akt signaling TYSND1 CLEAVES PEROXISOMAL PROTEINS%REACTOME DATABASE ID RELEASE 66%10146324 TYSND1 cleaves peroxisomal proteins INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX%REACTOME%R-RNO-141430.1 Inactivation of APC C via direct inhibition of the APC C complex GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION%REACTOME%R-RNO-162658.1 Golgi Cisternae Pericentriolar Stack Reorganization LYSOSOME VESICLE BIOGENESIS%REACTOME%R-RNO-432720.1 Lysosome Vesicle Biogenesis PD-1 SIGNALING%REACTOME%R-RNO-389948.1 PD-1 signaling TRANSPORT OF BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS%REACTOME%R-RNO-425366.1 Transport of bile salts and organic acids, metal ions and amine compounds SIGNALLING TO RAS%REACTOME DATABASE ID RELEASE 66%10145202 Signalling to RAS ACTIVATION OF NF-KAPPAB IN B CELLS%REACTOME%R-RNO-1169091.1 Activation of NF-kappaB in B cells NUCLEOSOME ASSEMBLY%REACTOME%R-RNO-774815.1 Nucleosome assembly DDX58 IFIH1-MEDIATED INDUCTION OF INTERFERON-ALPHA BETA%REACTOME%R-RNO-168928.1 DDX58 IFIH1-mediated induction of interferon-alpha beta EGFR DOWNREGULATION%REACTOME DATABASE ID RELEASE 66%10145266 EGFR downregulation INTERLEUKIN-1 FAMILY SIGNALING%REACTOME DATABASE ID RELEASE 66%10145170 Interleukin-1 family signaling SUMOYLATION OF INTRACELLULAR RECEPTORS%REACTOME%R-RNO-4090294.1 SUMOylation of intracellular receptors RUNX3 REGULATES P14-ARF%REACTOME DATABASE ID RELEASE 66%10146279 RUNX3 regulates p14-ARF ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS%REACTOME DATABASE ID RELEASE 66%10145174 ZBP1(DAI) mediated induction of type I IFNs PROTON OLIGOPEPTIDE COTRANSPORTERS%REACTOME DATABASE ID RELEASE 66%10145629 Proton oligopeptide cotransporters METALLOPROTEASE DUBS%REACTOME DATABASE ID RELEASE 66%10146145 Metalloprotease DUBs ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION%REACTOME%R-RNO-450302.1 activated TAK1 mediates p38 MAPK activation NEGATIVE FEEDBACK REGULATION OF MAPK PATHWAY%REACTOME%R-RNO-5674499.1 Negative feedback regulation of MAPK pathway ALPHA-OXIDATION OF PHYTANATE%REACTOME DATABASE ID RELEASE 66%10145549 Alpha-oxidation of phytanate LIGAND-DEPENDENT CASPASE ACTIVATION%REACTOME DATABASE ID RELEASE 66%10144860 Ligand-dependent caspase activation PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE%REACTOME DATABASE ID RELEASE 66%10144782 Pyruvate metabolism and Citric Acid (TCA) cycle CD28 DEPENDENT VAV1 PATHWAY%REACTOME DATABASE ID RELEASE 66%10145542 CD28 dependent Vav1 pathway AMINE LIGAND-BINDING RECEPTORS%REACTOME%R-RNO-375280.1 Amine ligand-binding receptors MRNA DECAY BY 5' TO 3' EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 66%10145636 mRNA decay by 5' to 3' exoribonuclease MOLYBDENUM COFACTOR BIOSYNTHESIS%REACTOME%R-RNO-947581.1 Molybdenum cofactor biosynthesis TRANSLESION SYNTHESIS BY Y FAMILY DNA POLYMERASES BYPASSES LESIONS ON DNA TEMPLATE%REACTOME DATABASE ID RELEASE 66%10144977 Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template HISTIDINE, LYSINE, PHENYLALANINE, TYROSINE, PROLINE AND TRYPTOPHAN CATABOLISM%REACTOME DATABASE ID RELEASE 66%10144795 Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism SPERM MOTILITY AND TAXES%REACTOME%R-RNO-1300642.1 Sperm Motility And Taxes ENZYMATIC DEGRADATION OF DOPAMINE BY COMT%REACTOME DATABASE ID RELEASE 66%10145520 Enzymatic degradation of dopamine by COMT REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE%REACTOME%R-RNO-176408.1 Regulation of APC C activators between G1 S and early anaphase RNA POLYMERASE III TRANSCRIPTION%REACTOME%R-RNO-74158.1 RNA Polymerase III Transcription ACTIVATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME DATABASE ID RELEASE 66%10144871 Activation of the phototransduction cascade FERTILIZATION%REACTOME%R-RNO-1187000.1 Fertilization SIGNAL AMPLIFICATION%REACTOME%R-RNO-392518.1 Signal amplification ACTIVATED PKN1 STIMULATES TRANSCRIPTION OF AR (ANDROGEN RECEPTOR) REGULATED GENES KLK2 AND KLK3%REACTOME DATABASE ID RELEASE 66%10146086 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE%REACTOME%R-RNO-174414.1 Processive synthesis on the C-strand of the telomere IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 66%10145133 Immune System PORPHYRIN METABOLISM%REACTOME DATABASE ID RELEASE 66%10145085 Porphyrin metabolism RA BIOSYNTHESIS PATHWAY%REACTOME%R-RNO-5365859.1 RA biosynthesis pathway CLASSICAL KIR CHANNELS%REACTOME DATABASE ID RELEASE 66%10145835 Classical Kir channels REGULATION BY C-FLIP%REACTOME DATABASE ID RELEASE 66%10146009 Regulation by c-FLIP PROTEIN UBIQUITINATION%REACTOME DATABASE ID RELEASE 66%10146215 Protein ubiquitination THROMBOXANE SIGNALLING THROUGH TP RECEPTOR%REACTOME%R-RNO-428930.1 Thromboxane signalling through TP receptor APC C:CDC20 MEDIATED DEGRADATION OF SECURIN%REACTOME%R-RNO-174154.1 APC C:Cdc20 mediated degradation of Securin SHC1 EVENTS IN EGFR SIGNALING%REACTOME%R-RNO-180336.1 SHC1 events in EGFR signaling CHYLOMICRON REMODELING%REACTOME DATABASE ID RELEASE 66%10145241 Chylomicron remodeling PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA%REACTOME%R-RNO-72203.1 Processing of Capped Intron-Containing Pre-mRNA INSULIN RECEPTOR RECYCLING%REACTOME%R-RNO-77387.1 Insulin receptor recycling INTERLEUKIN-6 SIGNALING%REACTOME DATABASE ID RELEASE 66%10145796 Interleukin-6 signaling ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%R-RNO-111447.1 Activation of BAD and translocation to mitochondria C-SRC MEDIATED REGULATION OF CX43 FUNCTION AND CLOSURE OF GAP JUNCTIONS%REACTOME%R-RNO-191647.1 c-src mediated regulation of Cx43 function and closure of gap junctions EUKARYOTIC TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 66%10144835 Eukaryotic Translation Initiation TIE2 SIGNALING%REACTOME%R-RNO-210993.1 Tie2 Signaling SMALL INTERFERING RNA (SIRNA) BIOGENESIS%REACTOME%R-RNO-426486.1 Small interfering RNA (siRNA) biogenesis ARACHIDONATE PRODUCTION FROM DAG%REACTOME%R-RNO-426048.1 Arachidonate production from DAG NUCLEOTIDE EXCISION REPAIR%REACTOME%R-RNO-5696398.1 Nucleotide Excision Repair CAP-DEPENDENT TRANSLATION INITIATION%REACTOME%R-RNO-72737.1 Cap-dependent Translation Initiation TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE%REACTOME%R-RNO-168188.1 Toll Like Receptor TLR6:TLR2 Cascade CARBOHYDRATE METABOLISM%REACTOME DATABASE ID RELEASE 66%10144766 Carbohydrate metabolism ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS%REACTOME%R-RNO-176187.1 Activation of ATR in response to replication stress EXTRACELLULAR MATRIX ORGANIZATION%REACTOME DATABASE ID RELEASE 66%10145031 Extracellular matrix organization LEADING STRAND SYNTHESIS%REACTOME%R-RNO-69109.1 Leading Strand Synthesis REGULATED PROTEOLYSIS OF P75NTR%REACTOME DATABASE ID RELEASE 66%10145335 Regulated proteolysis of p75NTR MISMATCH REPAIR (MMR) DIRECTED BY MSH2:MSH3 (MUTSBETA)%REACTOME%R-RNO-5358606.1 Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) NEUTROPHIL DEGRANULATION%REACTOME%R-RNO-6798695.1 Neutrophil degranulation REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA%REACTOME DATABASE ID RELEASE 66%10145918 Regulation of innate immune responses to cytosolic DNA RHO GTPASES ACTIVATE CIT%REACTOME DATABASE ID RELEASE 66%10146123 RHO GTPases activate CIT FORMATION OF INCISION COMPLEX IN GG-NER%REACTOME%R-RNO-5696395.1 Formation of Incision Complex in GG-NER NTF3 ACTIVATES NTRK3 SIGNALING%REACTOME%R-RNO-9034013.1 NTF3 activates NTRK3 signaling REMOVAL OF THE FLAP INTERMEDIATE%REACTOME DATABASE ID RELEASE 66%10144734 Removal of the Flap Intermediate THE PROTON BUFFERING MODEL%REACTOME%R-RNO-167827.1 The proton buffering model POTASSIUM TRANSPORT CHANNELS%REACTOME%R-RNO-1296067.1 Potassium transport channels RUNX2 REGULATES OSTEOBLAST DIFFERENTIATION%REACTOME%R-RNO-8940973.1 RUNX2 regulates osteoblast differentiation BUTYRATE RESPONSE FACTOR 1 (BRF1) BINDS AND DESTABILIZES MRNA%REACTOME%R-RNO-450385.1 Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA NEUROTRANSMITTER CLEARANCE%REACTOME%R-RNO-112311.1 Neurotransmitter clearance RUNX3 REGULATES YAP1-MEDIATED TRANSCRIPTION%REACTOME DATABASE ID RELEASE 66%10146278 RUNX3 regulates YAP1-mediated transcription ESTABLISHMENT OF SISTER CHROMATID COHESION%REACTOME DATABASE ID RELEASE 66%10145970 Establishment of Sister Chromatid Cohesion PRC2 METHYLATES HISTONES AND DNA%REACTOME%R-RNO-212300.1 PRC2 methylates histones and DNA FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION%REACTOME%R-RNO-434316.1 Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION%REACTOME%R-RNO-381340.1 Transcriptional regulation of white adipocyte differentiation INTERLEUKIN-20 FAMILY SIGNALING%REACTOME%R-RNO-8854691.1 Interleukin-20 family signaling RHO GTPASE EFFECTORS%REACTOME DATABASE ID RELEASE 66%10144888 RHO GTPase Effectors HDL CLEARANCE%REACTOME%R-RNO-8964011.1 HDL clearance BIOSYNTHESIS OF DHA-DERIVED SPMS%REACTOME DATABASE ID RELEASE 66%10146302 Biosynthesis of DHA-derived SPMs IRS-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%R-RNO-2428928.1 IRS-related events triggered by IGF1R INSULIN RECEPTOR SIGNALLING CASCADE%REACTOME DATABASE ID RELEASE 66%10144875 Insulin receptor signalling cascade P2Y RECEPTORS%REACTOME%R-RNO-417957.1 P2Y receptors REGULATION OF ORNITHINE DECARBOXYLASE (ODC)%REACTOME DATABASE ID RELEASE 66%10145465 Regulation of ornithine decarboxylase (ODC) TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS%REACTOME%R-RNO-174417.1 Telomere C-strand (Lagging Strand) Synthesis PROTON-COUPLED MONOCARBOXYLATE TRANSPORT%REACTOME DATABASE ID RELEASE 66%10145649 Proton-coupled monocarboxylate transport INSULIN EFFECTS INCREASED SYNTHESIS OF XYLULOSE-5-PHOSPHATE%REACTOME%R-RNO-163754.1 Insulin effects increased synthesis of Xylulose-5-Phosphate TRANSPORT OF NUCLEOSIDES AND FREE PURINE AND PYRIMIDINE BASES ACROSS THE PLASMA MEMBRANE%REACTOME%R-RNO-83936.1 Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane METHYLATION%REACTOME DATABASE ID RELEASE 66%10144922 Methylation GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION%REACTOME%R-RNO-381676.1 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion CHYLOMICRON ASSEMBLY%REACTOME DATABASE ID RELEASE 66%10145238 Chylomicron assembly MYD88-INDEPENDENT TLR4 CASCADE%REACTOME%R-RNO-166166.1 MyD88-independent TLR4 cascade HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145724 Highly calcium permeable postsynaptic nicotinic acetylcholine receptors G ALPHA (12 13) SIGNALLING EVENTS%REACTOME%R-RNO-416482.1 G alpha (12 13) signalling events EPHRIN SIGNALING%REACTOME%R-RNO-3928664.1 Ephrin signaling METABOLISM OF NITRIC OXIDE%REACTOME DATABASE ID RELEASE 66%10145396 Metabolism of nitric oxide SUMOYLATION OF UBIQUITINYLATION PROTEINS%REACTOME%R-RNO-3232142.1 SUMOylation of ubiquitinylation proteins SIGNALING BY TGF-BETA RECEPTOR COMPLEX%REACTOME%R-RNO-170834.1 Signaling by TGF-beta Receptor Complex SIGNALING BY HEDGEHOG%REACTOME%R-RNO-5358351.1 Signaling by Hedgehog GABA A (RHO) RECEPTOR ACTIVATION%REACTOME DATABASE ID RELEASE 66%10145776 GABA A (rho) receptor activation SYNTHESIS OF PIPS IN THE NUCLEUS%REACTOME%R-RNO-8847453.1 Synthesis of PIPs in the nucleus TP53 REGULATES METABOLIC GENES%REACTOME DATABASE ID RELEASE 66%10144779 TP53 Regulates Metabolic Genes VLDL ASSEMBLY%REACTOME%R-RNO-8866423.1 VLDL assembly GLYCOSPHINGOLIPID METABOLISM%REACTOME%R-RNO-1660662.1 Glycosphingolipid metabolism PCP CE PATHWAY%REACTOME%R-RNO-4086400.1 PCP CE pathway OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA%REACTOME%R-RNO-1234176.1 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha OREXIN AND NEUROPEPTIDES FF AND QRFP BIND TO THEIR RESPECTIVE RECEPTORS%REACTOME%R-RNO-389397.1 Orexin and neuropeptides FF and QRFP bind to their respective receptors REGULATION OF TP53 EXPRESSION AND DEGRADATION%REACTOME%R-RNO-6806003.1 Regulation of TP53 Expression and Degradation METABOLISM OF SEROTONIN%REACTOME%R-RNO-380612.1 Metabolism of serotonin ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION%REACTOME DATABASE ID RELEASE 66%10145589 Adrenaline,noradrenaline inhibits insulin secretion DECTIN-1 MEDIATED NONCANONICAL NF-KB SIGNALING%REACTOME%R-RNO-5607761.1 Dectin-1 mediated noncanonical NF-kB signaling NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME DATABASE ID RELEASE 66%10145920 NOTCH2 Activation and Transmission of Signal to the Nucleus ESTROGEN-DEPENDENT GENE EXPRESSION%REACTOME%R-RNO-9018519.1 Estrogen-dependent gene expression TRIGLYCERIDE METABOLISM%REACTOME%R-RNO-8979227.1 Triglyceride metabolism P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME%R-RNO-372708.1 p130Cas linkage to MAPK signaling for integrins PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145719 Presynaptic nicotinic acetylcholine receptors PRE-MRNA SPLICING%REACTOME DATABASE ID RELEASE 66%10144828 pre-mRNA splicing BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS%REACTOME DATABASE ID RELEASE 66%10145554 Beta-oxidation of very long chain fatty acids PKMTS METHYLATE HISTONE LYSINES%REACTOME DATABASE ID RELEASE 66%10146041 PKMTs methylate histone lysines CHROMATIN MODIFYING ENZYMES%REACTOME%R-RNO-3247509.1 Chromatin modifying enzymes LGI-ADAM INTERACTIONS%REACTOME%R-RNO-5682910.1 LGI-ADAM interactions TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION%REACTOME DATABASE ID RELEASE 66%10145151 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7 8 or 9 activation METHIONINE SALVAGE PATHWAY%REACTOME DATABASE ID RELEASE 66%10145821 Methionine salvage pathway METABOLISM OF LIPIDS%REACTOME%R-RNO-556833.1 Metabolism of lipids INWARDLY RECTIFYING K+ CHANNELS%REACTOME DATABASE ID RELEASE 66%10145793 Inwardly rectifying K+ channels TFAP2 (AP-2) FAMILY REGULATES TRANSCRIPTION OF GROWTH FACTORS AND THEIR RECEPTORS%REACTOME%R-RNO-8866910.1 TFAP2 (AP-2) family regulates transcription of growth factors and their receptors SIGNALING BY ROBO RECEPTORS%REACTOME%R-RNO-376176.1 Signaling by ROBO receptors ORGANIC ANION TRANSPORTERS%REACTOME DATABASE ID RELEASE 66%10145484 Organic anion transporters AXONAL GROWTH INHIBITION (RHOA ACTIVATION)%REACTOME%R-RNO-193634.1 Axonal growth inhibition (RHOA activation) DOWNREGULATION OF ERBB2 SIGNALING%REACTOME%R-RNO-8863795.1 Downregulation of ERBB2 signaling ROS, RNS PRODUCTION IN PHAGOCYTES%REACTOME DATABASE ID RELEASE 66%10145602 ROS, RNS production in phagocytes GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME%R-RNO-354194.1 GRB2:SOS provides linkage to MAPK signaling for Integrins AMPLIFICATION OF SIGNAL FROM UNATTACHED KINETOCHORES VIA A MAD2 INHIBITORY SIGNAL%REACTOME DATABASE ID RELEASE 66%10145062 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal GDP-FUCOSE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 66%10145727 GDP-fucose biosynthesis REGULATION OF SIGNALING BY CBL%REACTOME%R-RNO-912631.1 Regulation of signaling by CBL CALNEXIN CALRETICULIN CYCLE%REACTOME DATABASE ID RELEASE 66%10145711 Calnexin calreticulin cycle COLLAGEN CHAIN TRIMERIZATION%REACTOME DATABASE ID RELEASE 66%10145922 Collagen chain trimerization SHC-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%R-RNO-2428933.1 SHC-related events triggered by IGF1R RAS ACTIVATION UPON CA2+ INFLUX THROUGH NMDA RECEPTOR%REACTOME%R-RNO-442982.1 Ras activation upon Ca2+ influx through NMDA receptor FRS-MEDIATED FGFR1 SIGNALING%REACTOME DATABASE ID RELEASE 66%10146102 FRS-mediated FGFR1 signaling MASTL FACILITATES MITOTIC PROGRESSION%REACTOME%R-RNO-2465910.1 MASTL Facilitates Mitotic Progression SYNTHESIS OF PE%REACTOME%R-RNO-1483213.1 Synthesis of PE INOSITOL TRANSPORTERS%REACTOME DATABASE ID RELEASE 66%10145635 Inositol transporters PHOSPHOLIPID METABOLISM%REACTOME%R-RNO-1483257.1 Phospholipid metabolism BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN%REACTOME%R-RNO-446193.1 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein BBSOME-MEDIATED CARGO-TARGETING TO CILIUM%REACTOME DATABASE ID RELEASE 66%10146078 BBSome-mediated cargo-targeting to cilium ACYL CHAIN REMODELLING OF PE%REACTOME%R-RNO-1482839.1 Acyl chain remodelling of PE RESOLUTION OF ABASIC SITES (AP SITES)%REACTOME%R-RNO-73933.1 Resolution of Abasic Sites (AP sites) ACTIVATION OF AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145580 Activation of AMPA receptors ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS%REACTOME%R-RNO-2122948.1 Activated NOTCH1 Transmits Signal to the Nucleus SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX)%REACTOME DATABASE ID RELEASE 66%10145441 Synthesis of Leukotrienes (LT) and Eoxins (EX) METABOLISM OF VITAMIN K%REACTOME%R-RNO-6806664.1 Metabolism of vitamin K OVARIAN TUMOR DOMAIN PROTEASES%REACTOME%R-RNO-5689896.1 Ovarian tumor domain proteases TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G2 CELL CYCLE ARREST%REACTOME DATABASE ID RELEASE 66%10146160 TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest EPHB-MEDIATED FORWARD SIGNALING%REACTOME DATABASE ID RELEASE 66%10146024 EPHB-mediated forward signaling APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS%REACTOME DATABASE ID RELEASE 66%10145068 APC C-mediated degradation of cell cycle proteins THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT%REACTOME DATABASE ID RELEASE 66%10144783 The citric acid (TCA) cycle and respiratory electron transport BIOTIN TRANSPORT AND METABOLISM%REACTOME DATABASE ID RELEASE 66%10145370 Biotin transport and metabolism SHC-MEDIATED CASCADE:FGFR1%REACTOME DATABASE ID RELEASE 66%10146109 SHC-mediated cascade:FGFR1 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE%REACTOME%R-RNO-77075.1 RNA Pol II CTD phosphorylation and interaction with CE AMINO ACID CONJUGATION%REACTOME DATABASE ID RELEASE 66%10145091 Amino Acid conjugation ALPHA-LINOLENIC ACID (ALA) METABOLISM%REACTOME%R-RNO-2046106.1 alpha-linolenic acid (ALA) metabolism THE PHOTOTRANSDUCTION CASCADE%REACTOME DATABASE ID RELEASE 66%10144866 The phototransduction cascade MITOCHONDRIAL FATTY ACID BETA-OXIDATION%REACTOME%R-RNO-77289.1 Mitochondrial Fatty Acid Beta-Oxidation SULFUR AMINO ACID METABOLISM%REACTOME%R-RNO-1614635.1 Sulfur amino acid metabolism NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 66%10145481 Norepinephrine Neurotransmitter Release Cycle BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145954 Binding and Uptake of Ligands by Scavenger Receptors FCERI MEDIATED CA+2 MOBILIZATION%REACTOME%R-RNO-2871809.1 FCERI mediated Ca+2 mobilization BIOSYNTHESIS OF ELECTROPHILIC Ω-3 PUFA OXO-DERIVATIVES%REACTOME DATABASE ID RELEASE 66%10146319 Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives PTEN REGULATION%REACTOME%R-RNO-6807070.1 PTEN Regulation TFAP2A ACTS AS A TRANSCRIPTIONAL REPRESSOR DURING RETINOIC ACID INDUCED CELL DIFFERENTIATION%REACTOME%R-RNO-8869496.1 TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1)%REACTOME DATABASE ID RELEASE 66%10145538 Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) TOLL LIKE RECEPTOR 4 (TLR4) CASCADE%REACTOME DATABASE ID RELEASE 66%10145130 Toll Like Receptor 4 (TLR4) Cascade ADENYLATE CYCLASE ACTIVATING PATHWAY%REACTOME DATABASE ID RELEASE 66%10145191 Adenylate cyclase activating pathway SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL%REACTOME DATABASE ID RELEASE 66%10145908 Synthesis of pyrophosphates in the cytosol NEGATIVE REGULATION OF ACTIVITY OF TFAP2 (AP-2) FAMILY TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 66%10146003 Negative regulation of activity of TFAP2 (AP-2) family transcription factors VLDL CLEARANCE%REACTOME DATABASE ID RELEASE 66%10146224 VLDL clearance RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF HSCS%REACTOME DATABASE ID RELEASE 66%10146239 RUNX1 regulates transcription of genes involved in differentiation of HSCs BIOSYNTHESIS OF DPAN-6 SPMS%REACTOME DATABASE ID RELEASE 66%10146307 Biosynthesis of DPAn-6 SPMs GROWTH HORMONE RECEPTOR SIGNALING%REACTOME DATABASE ID RELEASE 66%10145708 Growth hormone receptor signaling REUPTAKE OF GABA%REACTOME%R-RNO-888593.1 Reuptake of GABA THYROXINE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 66%10145424 Thyroxine biosynthesis PLATELET ADHESION TO EXPOSED COLLAGEN%REACTOME%R-RNO-75892.1 Platelet Adhesion to exposed collagen INITIAL TRIGGERING OF COMPLEMENT%REACTOME%R-RNO-166663.1 Initial triggering of complement FORMATION OF THE CORNIFIED ENVELOPE%REACTOME%R-RNO-6809371.1 Formation of the cornified envelope SIGNALING BY MET%REACTOME%R-RNO-6806834.1 Signaling by MET RHO GTPASES ACTIVATE FORMINS%REACTOME%R-RNO-5663220.1 RHO GTPases Activate Formins CITRIC ACID CYCLE (TCA CYCLE)%REACTOME%R-RNO-71403.1 Citric acid cycle (TCA cycle) CHAPERONIN-MEDIATED PROTEIN FOLDING%REACTOME%R-RNO-390466.1 Chaperonin-mediated protein folding KINESINS%REACTOME%R-RNO-983189.1 Kinesins SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL%REACTOME DATABASE ID RELEASE 66%10145904 Synthesis of IP3 and IP4 in the cytosol CARGO RECOGNITION FOR CLATHRIN-MEDIATED ENDOCYTOSIS%REACTOME%R-RNO-8856825.1 Cargo recognition for clathrin-mediated endocytosis ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR%REACTOME DATABASE ID RELEASE 66%10145698 Activation of Ca-permeable Kainate Receptor SIGNALING BY RHO GTPASES%REACTOME DATABASE ID RELEASE 66%10144889 Signaling by Rho GTPases OLIGOMERIZATION OF CONNEXINS INTO CONNEXONS%REACTOME DATABASE ID RELEASE 66%10145304 Oligomerization of connexins into connexons CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKK%REACTOME%R-RNO-442717.1 CREB phosphorylation through the activation of CaMKK PEPTIDE CHAIN ELONGATION%REACTOME%R-RNO-156902.1 Peptide chain elongation CLASS B 2 (SECRETIN FAMILY RECEPTORS)%REACTOME%R-RNO-373080.1 Class B 2 (Secretin family receptors) ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME DATABASE ID RELEASE 66%10145219 Activation of APC C and APC C:Cdc20 mediated degradation of mitotic proteins IRE1ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 66%10145532 IRE1alpha activates chaperones RHESUS GLYCOPROTEINS MEDIATE AMMONIUM TRANSPORT.%REACTOME DATABASE ID RELEASE 66%10145662 Rhesus glycoproteins mediate ammonium transport. RNA POLYMERASE I TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 66%10144885 RNA Polymerase I Transcription Termination APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B%REACTOME%R-RNO-174048.1 APC C:Cdc20 mediated degradation of Cyclin B MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME%REACTOME%R-RNO-975155.1 MyD88 dependent cascade initiated on endosome DSCAM INTERACTIONS%REACTOME%R-RNO-376172.1 DSCAM interactions MISCELLANEOUS TRANSPORT AND BINDING EVENTS%REACTOME%R-RNO-5223345.1 Miscellaneous transport and binding events MITOCHONDRIAL TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 66%10145117 Mitochondrial transcription initiation PINK PARKIN MEDIATED MITOPHAGY%REACTOME DATABASE ID RELEASE 66%10146045 Pink Parkin Mediated Mitophagy SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R)%REACTOME%R-RNO-2404192.1 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) INTERCONVERSION OF POLYAMINES%REACTOME DATABASE ID RELEASE 66%10145061 Interconversion of polyamines NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%R-RNO-2122947.1 NOTCH1 Intracellular Domain Regulates Transcription ELECTRIC TRANSMISSION ACROSS GAP JUNCTIONS%REACTOME DATABASE ID RELEASE 66%10145507 Electric Transmission Across Gap Junctions THE NLRP3 INFLAMMASOME%REACTOME%R-RNO-844456.1 The NLRP3 inflammasome FCGR ACTIVATION%REACTOME DATABASE ID RELEASE 66%10145910 FCGR activation SLIT2:ROBO1 INCREASES RHOA ACTIVITY%REACTOME DATABASE ID RELEASE 66%10146285 SLIT2:ROBO1 increases RHOA activity TICAM1-DEPENDENT ACTIVATION OF IRF3 IRF7%REACTOME DATABASE ID RELEASE 66%10145179 TICAM1-dependent activation of IRF3 IRF7 COX REACTIONS%REACTOME DATABASE ID RELEASE 66%10145051 COX reactions SIGNALING BY VEGF%REACTOME DATABASE ID RELEASE 66%10145273 Signaling by VEGF REGULATION OF MECP2 EXPRESSION AND ACTIVITY%REACTOME%R-RNO-9022692.1 Regulation of MECP2 expression and activity ACTIVATION OF TRKA RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145141 Activation of TRKA receptors DOWNSTREAM SIGNALING OF ACTIVATED FGFR2%REACTOME DATABASE ID RELEASE 66%10145255 Downstream signaling of activated FGFR2 VASOPRESSIN-LIKE RECEPTORS%REACTOME%R-RNO-388479.1 Vasopressin-like receptors ANCHORING OF THE BASAL BODY TO THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 66%10146081 Anchoring of the basal body to the plasma membrane ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION%REACTOME%R-RNO-2730905.1 Role of LAT2 NTAL LAB on calcium mobilization NEPHRIN FAMILY INTERACTIONS%REACTOME%R-RNO-373753.1 Nephrin family interactions IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX%REACTOME%R-RNO-937042.1 IRAK2 mediated activation of TAK1 complex PYRIMIDINE SALVAGE%REACTOME DATABASE ID RELEASE 66%10144845 Pyrimidine salvage TWIK-RELATED ALKALINE PH ACTIVATED K+ CHANNEL (TALK)%REACTOME DATABASE ID RELEASE 66%10145847 TWIK-related alkaline pH activated K+ channel (TALK) THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS)%REACTOME%R-RNO-456926.1 Thrombin signalling through proteinase activated receptors (PARs) DEADENYLATION OF MRNA%REACTOME DATABASE ID RELEASE 66%10145638 Deadenylation of mRNA FORMYL PEPTIDE RECEPTORS BIND FORMYL PEPTIDES AND MANY OTHER LIGANDS%REACTOME DATABASE ID RELEASE 66%10145663 Formyl peptide receptors bind formyl peptides and many other ligands ACTIVATION AND OLIGOMERIZATION OF BAK PROTEIN%REACTOME DATABASE ID RELEASE 66%10145015 Activation and oligomerization of BAK protein A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS%REACTOME%R-RNO-1971475.1 A tetrasaccharide linker sequence is required for GAG synthesis PKA ACTIVATION IN GLUCAGON SIGNALLING%REACTOME%R-RNO-164378.1 PKA activation in glucagon signalling CLASS C 3 (METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS)%REACTOME DATABASE ID RELEASE 66%10145488 Class C 3 (Metabotropic glutamate pheromone receptors) CA-DEPENDENT EVENTS%REACTOME DATABASE ID RELEASE 66%10144989 Ca-dependent events SUMOYLATION OF RNA BINDING PROTEINS%REACTOME DATABASE ID RELEASE 66%10146034 SUMOylation of RNA binding proteins VITAMIN B5 (PANTOTHENATE) METABOLISM%REACTOME%R-RNO-199220.1 Vitamin B5 (pantothenate) metabolism ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING%REACTOME%R-RNO-451326.1 Activation of kainate receptors upon glutamate binding TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS%REACTOME DATABASE ID RELEASE 66%10145878 Transcriptional activation of mitochondrial biogenesis DOWNSTREAM SIGNALING OF ACTIVATED FGFR1%REACTOME%R-RNO-5654687.1 Downstream signaling of activated FGFR1 TRP CHANNELS%REACTOME%R-RNO-3295583.1 TRP channels SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION%REACTOME%R-RNO-2173796.1 SMAD2 SMAD3:SMAD4 heterotrimer regulates transcription DARPP-32 EVENTS%REACTOME DATABASE ID RELEASE 66%10145005 DARPP-32 events ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON%REACTOME DATABASE ID RELEASE 66%10145137 Activation of IRF3 IRF7 mediated by TBK1 IKK epsilon GLUCAGON-TYPE LIGAND RECEPTORS%REACTOME%R-RNO-420092.1 Glucagon-type ligand receptors SUMO E3 LIGASES SUMOYLATE TARGET PROTEINS%REACTOME DATABASE ID RELEASE 66%10145992 SUMO E3 ligases SUMOylate target proteins AXON GUIDANCE%REACTOME%R-RNO-422475.1 Axon guidance SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE%REACTOME%R-RNO-416572.1 Sema4D induced cell migration and growth-cone collapse FREE FATTY ACIDS REGULATE INSULIN SECRETION%REACTOME DATABASE ID RELEASE 66%10145587 Free fatty acids regulate insulin secretion SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN%REACTOME DATABASE ID RELEASE 66%10145615 Synthesis, secretion, and deacylation of Ghrelin SIGNALING BY NOTCH3%REACTOME DATABASE ID RELEASE 66%10145952 Signaling by NOTCH3 OXYGEN-DEPENDENT ASPARAGINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA%REACTOME DATABASE ID RELEASE 66%10145810 Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha REPRODUCTION%REACTOME%R-RNO-1474165.1 Reproduction PHOSPHOLIPASE C-MEDIATED CASCADE: FGFR1%REACTOME%R-RNO-5654219.1 Phospholipase C-mediated cascade: FGFR1 MELANIN BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 66%10146119 Melanin biosynthesis DIGESTION AND ABSORPTION%REACTOME%R-RNO-8963743.1 Digestion and absorption GAP JUNCTION DEGRADATION%REACTOME DATABASE ID RELEASE 66%10145296 Gap junction degradation O-LINKED GLYCOSYLATION OF MUCINS%REACTOME%R-RNO-913709.1 O-linked glycosylation of mucins CTLA4 INHIBITORY SIGNALING%REACTOME DATABASE ID RELEASE 66%10145541 CTLA4 inhibitory signaling PENTOSE PHOSPHATE PATHWAY%REACTOME%R-RNO-71336.1 Pentose phosphate pathway UBIQUINOL BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 66%10145949 Ubiquinol biosynthesis PHASE I - FUNCTIONALIZATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 66%10144820 Phase I - Functionalization of compounds PRESYNAPTIC PHASE OF HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME DATABASE ID RELEASE 66%10146131 Presynaptic phase of homologous DNA pairing and strand exchange SLC-MEDIATED TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 66%10144952 SLC-mediated transmembrane transport ASYMMETRIC LOCALIZATION OF PCP PROTEINS%REACTOME%R-RNO-4608870.1 Asymmetric localization of PCP proteins ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12%REACTOME%R-RNO-392170.1 ADP signalling through P2Y purinoceptor 12 SIGNALING BY TGF-BETA FAMILY MEMBERS%REACTOME DATABASE ID RELEASE 66%10145195 Signaling by TGF-beta family members MITOTIC G2-G2 M PHASES%REACTOME DATABASE ID RELEASE 66%10145075 Mitotic G2-G2 M phases SIGNALLING TO ERK5%REACTOME DATABASE ID RELEASE 66%10145365 Signalling to ERK5 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS.%REACTOME%R-RNO-163200.1 Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. MYD88:MAL(TIRAP) CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME%R-RNO-166058.1 MyD88:MAL(TIRAP) cascade initiated on plasma membrane FORMATION OF THE ACTIVE COFACTOR, UDP-GLUCURONATE%REACTOME DATABASE ID RELEASE 66%10144771 Formation of the active cofactor, UDP-glucuronate GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK%REACTOME DATABASE ID RELEASE 66%10145366 Gastrin-CREB signalling pathway via PKC and MAPK INTRACELLULAR OXYGEN TRANSPORT%REACTOME%R-RNO-8981607.1 Intracellular oxygen transport NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS%REACTOME DATABASE ID RELEASE 66%10145178 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways VITAMINS B6 ACTIVATION TO PYRIDOXAL PHOSPHATE%REACTOME%R-RNO-964975.1 Vitamins B6 activation to pyridoxal phosphate SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION%REACTOME DATABASE ID RELEASE 66%10145592 Sema4D mediated inhibition of cell attachment and migration WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2%REACTOME%R-RNO-5140745.1 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME%R-RNO-110381.1 Resolution of AP sites via the single-nucleotide replacement pathway SCAVENGING BY CLASS B RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145958 Scavenging by Class B Receptors REGULATION OF TLR BY ENDOGENOUS LIGAND%REACTOME DATABASE ID RELEASE 66%10146066 Regulation of TLR by endogenous ligand NOTCH-HLH TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 66%10145446 Notch-HLH transcription pathway VITAMINS%REACTOME%R-RNO-211916.1 Vitamins UCH PROTEINASES%REACTOME DATABASE ID RELEASE 66%10146120 UCH proteinases ADRENOCEPTORS%REACTOME%R-RNO-390696.1 Adrenoceptors REGULATION OF TP53 EXPRESSION%REACTOME DATABASE ID RELEASE 66%10146179 Regulation of TP53 Expression POST-TRANSLATIONAL PROTEIN MODIFICATION%REACTOME%R-RNO-597592.1 Post-translational protein modification FGFR1B LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 66%10145285 FGFR1b ligand binding and activation HOMOLOGY DIRECTED REPAIR%REACTOME DATABASE ID RELEASE 66%10144914 Homology Directed Repair TRANSCRIPTION-COUPLED NUCLEOTIDE EXCISION REPAIR (TC-NER)%REACTOME%R-RNO-6781827.1 Transcription-Coupled Nucleotide Excision Repair (TC-NER) TRANSCRIPTIONAL REGULATION BY RUNX2%REACTOME DATABASE ID RELEASE 66%10146258 Transcriptional regulation by RUNX2 PRE-NOTCH PROCESSING IN GOLGI%REACTOME%R-RNO-1912420.1 Pre-NOTCH Processing in Golgi CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA%REACTOME DATABASE ID RELEASE 66%10145175 Cytosolic sensors of pathogen-associated DNA HDL ASSEMBLY%REACTOME DATABASE ID RELEASE 66%10145449 HDL assembly ERYTHROCYTES TAKE UP OXYGEN AND RELEASE CARBON DIOXIDE%REACTOME DATABASE ID RELEASE 66%10145820 Erythrocytes take up oxygen and release carbon dioxide REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN%REACTOME%R-RNO-1234174.1 Regulation of Hypoxia-inducible Factor (HIF) by oxygen PHASE 2 - PLATEAU PHASE%REACTOME%R-RNO-5576893.1 Phase 2 - plateau phase GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER%REACTOME%R-RNO-6782210.1 Gap-filling DNA repair synthesis and ligation in TC-NER RHO GTPASE CYCLE%REACTOME DATABASE ID RELEASE 66%10145340 Rho GTPase cycle GLUTATHIONE CONJUGATION%REACTOME%R-RNO-156590.1 Glutathione conjugation PTK6 DOWN-REGULATION%REACTOME DATABASE ID RELEASE 66%10146208 PTK6 Down-Regulation TP53 REGULATES TRANSCRIPTION OF SEVERAL ADDITIONAL CELL DEATH GENES WHOSE SPECIFIC ROLES IN P53-DEPENDENT APOPTOSIS REMAIN UNCERTAIN%REACTOME DATABASE ID RELEASE 66%10146175 TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain CYCLIN A B1 B2 ASSOCIATED EVENTS DURING G2 M TRANSITION%REACTOME%R-RNO-69273.1 Cyclin A B1 B2 associated events during G2 M transition SPHINGOLIPID METABOLISM%REACTOME%R-RNO-428157.1 Sphingolipid metabolism SPERM:OOCYTE MEMBRANE BINDING%REACTOME DATABASE ID RELEASE 66%10145840 Sperm:Oocyte Membrane Binding CRISTAE FORMATION%REACTOME%R-RNO-8949613.1 Cristae formation AROMATIC AMINES CAN BE N-HYDROXYLATED OR N-DEALKYLATED BY CYP1A2%REACTOME%R-RNO-211957.1 Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 ABACAVIR TRANSPORT AND METABOLISM%REACTOME DATABASE ID RELEASE 66%10145942 Abacavir transport and metabolism REGULATION OF CYTOSKELETAL REMODELING AND CELL SPREADING BY IPP COMPLEX COMPONENTS%REACTOME DATABASE ID RELEASE 66%10145641 Regulation of cytoskeletal remodeling and cell spreading by IPP complex components PHOSPHOLIPASE C-MEDIATED CASCADE; FGFR3%REACTOME DATABASE ID RELEASE 66%10146099 Phospholipase C-mediated cascade; FGFR3 RAF MAP KINASE CASCADE%REACTOME%R-RNO-5673001.1 RAF MAP kinase cascade ABASIC SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 66%10144981 Abasic sugar-phosphate removal via the single-nucleotide replacement pathway CRMPS IN SEMA3A SIGNALING%REACTOME%R-RNO-399956.1 CRMPs in Sema3A signaling REGULATION OF TP53 ACTIVITY THROUGH ACETYLATION%REACTOME DATABASE ID RELEASE 66%10146001 Regulation of TP53 Activity through Acetylation BIOSYNTHESIS OF MARESINS%REACTOME%R-RNO-9018682.1 Biosynthesis of maresins TP53 REGULATES TRANSCRIPTION OF CELL CYCLE GENES%REACTOME%R-RNO-6791312.1 TP53 Regulates Transcription of Cell Cycle Genes PLC BETA MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 66%10144985 PLC beta mediated events REGULATION OF EXPRESSION OF SLITS AND ROBOS%REACTOME DATABASE ID RELEASE 66%10146286 Regulation of expression of SLITs and ROBOs GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION%REACTOME DATABASE ID RELEASE 66%10145475 GABA synthesis, release, reuptake and degradation INTEGRIN ALPHAIIB BETA3 SIGNALING%REACTOME DATABASE ID RELEASE 66%10145476 Integrin alphaIIb beta3 signaling FCERI MEDIATED MAPK ACTIVATION%REACTOME DATABASE ID RELEASE 66%10145166 FCERI mediated MAPK activation PTK6 ACTIVATES STAT3%REACTOME DATABASE ID RELEASE 66%10146200 PTK6 Activates STAT3 CLEC7A INFLAMMASOME PATHWAY%REACTOME%R-RNO-5660668.1 CLEC7A inflammasome pathway SIGNALING BY NTRK1 (TRKA)%REACTOME%R-RNO-187037.1 Signaling by NTRK1 (TRKA) PEPTIDE HORMONE METABOLISM%REACTOME%R-RNO-2980736.1 Peptide hormone metabolism CELL CYCLE%REACTOME DATABASE ID RELEASE 66%10144722 Cell Cycle TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G1 CELL CYCLE ARREST%REACTOME%R-RNO-6804116.1 TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest INTERLEUKIN-2 SIGNALING%REACTOME%R-RNO-9020558.1 Interleukin-2 signaling DEPURINATION%REACTOME DATABASE ID RELEASE 66%10144975 Depurination G2 M DNA REPLICATION CHECKPOINT%REACTOME%R-RNO-69478.1 G2 M DNA replication checkpoint FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX%REACTOME DATABASE ID RELEASE 66%10145392 Formation of the beta-catenin:TCF transactivating complex ACTIVATION OF THE TFAP2 (AP-2) FAMILY OF TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 66%10146233 Activation of the TFAP2 (AP-2) family of transcription factors ATF6 (ATF6-ALPHA) ACTIVATES CHAPERONES%REACTOME%R-RNO-381033.1 ATF6 (ATF6-alpha) activates chaperones SHC-MEDIATED CASCADE:FGFR2%REACTOME%R-RNO-5654699.1 SHC-mediated cascade:FGFR2 G1 PHASE%REACTOME%R-RNO-69236.1 G1 Phase SYNTHESIS OF CL%REACTOME DATABASE ID RELEASE 66%10145873 Synthesis of CL SIGNALING BY PDGF%REACTOME DATABASE ID RELEASE 66%10145268 Signaling by PDGF SIGNALING BY FGFR%REACTOME DATABASE ID RELEASE 66%10145253 Signaling by FGFR FRS-MEDIATED FGFR3 SIGNALING%REACTOME%R-RNO-5654706.1 FRS-mediated FGFR3 signaling ACTIVATION OF DNA FRAGMENTATION FACTOR%REACTOME DATABASE ID RELEASE 66%10145439 Activation of DNA fragmentation factor CASPASE ACTIVATION VIA EXTRINSIC APOPTOTIC SIGNALLING PATHWAY%REACTOME%R-RNO-5357769.1 Caspase activation via extrinsic apoptotic signalling pathway INTERLEUKIN-21 SIGNALING%REACTOME%R-RNO-9020958.1 Interleukin-21 signaling BETA-CATENIN INDEPENDENT WNT SIGNALING%REACTOME DATABASE ID RELEASE 66%10145579 Beta-catenin independent WNT signaling PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS%REACTOME%R-RNO-73817.1 Purine ribonucleoside monophosphate biosynthesis GRB7 EVENTS IN ERBB2 SIGNALING%REACTOME%R-RNO-1306955.1 GRB7 events in ERBB2 signaling DEFENSINS%REACTOME%R-RNO-1461973.1 Defensins RUNX2 REGULATES BONE DEVELOPMENT%REACTOME DATABASE ID RELEASE 66%10146257 RUNX2 regulates bone development PROPIONYL-COA CATABOLISM%REACTOME DATABASE ID RELEASE 66%10144800 Propionyl-CoA catabolism KANDUTSCH-RUSSELL PATHWAY%REACTOME DATABASE ID RELEASE 66%10146182 Kandutsch-Russell pathway COMPLEMENT CASCADE%REACTOME%R-RNO-166658.1 Complement cascade MYD88 CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 66%10145155 MyD88 cascade initiated on plasma membrane INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS%REACTOME%R-RNO-141405.1 Inhibition of the proteolytic activity of APC C required for the onset of anaphase by mitotic spindle checkpoint components INTESTINAL HEXOSE ABSORPTION%REACTOME%R-RNO-8981373.1 Intestinal hexose absorption DOPAMINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME%R-RNO-212676.1 Dopamine Neurotransmitter Release Cycle MET ACTIVATES RAS SIGNALING%REACTOME DATABASE ID RELEASE 66%10146212 MET activates RAS signaling DAP12 SIGNALING%REACTOME DATABASE ID RELEASE 66%10145432 DAP12 signaling GAB1 SIGNALOSOME%REACTOME DATABASE ID RELEASE 66%10145248 GAB1 signalosome RIPK1-MEDIATED REGULATED NECROSIS%REACTOME%R-RNO-5213460.1 RIPK1-mediated regulated necrosis REGULATION OF PTEN GENE TRANSCRIPTION%REACTOME%R-RNO-8943724.1 Regulation of PTEN gene transcription AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1%REACTOME DATABASE ID RELEASE 66%10145450 Autodegradation of the E3 ubiquitin ligase COP1 GENE EXPRESSION (TRANSCRIPTION)%REACTOME DATABASE ID RELEASE 66%10144751 Gene expression (Transcription) MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES%REACTOME%R-RNO-450282.1 MAPK targets Nuclear events mediated by MAP kinases RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER%REACTOME%R-RNO-76071.1 RNA Polymerase III Transcription Initiation From Type 3 Promoter HSF1-DEPENDENT TRANSACTIVATION%REACTOME%R-RNO-3371571.1 HSF1-dependent transactivation DOWNSTREAM TCR SIGNALING%REACTOME DATABASE ID RELEASE 66%10145375 Downstream TCR signaling P75NTR RECRUITS SIGNALLING COMPLEXES%REACTOME%R-RNO-209543.1 p75NTR recruits signalling complexes CHOLESTEROL BIOSYNTHESIS%REACTOME%R-RNO-191273.1 Cholesterol biosynthesis MEMBRANE TRAFFICKING%REACTOME DATABASE ID RELEASE 66%10145299 Membrane Trafficking HIGHLY CALCIUM PERMEABLE NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%R-RNO-629597.1 Highly calcium permeable nicotinic acetylcholine receptors PHASE 1 - INACTIVATION OF FAST NA+ CHANNELS%REACTOME DATABASE ID RELEASE 66%10146070 Phase 1 - inactivation of fast Na+ channels TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR%REACTOME DATABASE ID RELEASE 66%10145903 Trafficking and processing of endosomal TLR INTEGRATION OF ENERGY METABOLISM%REACTOME%R-RNO-163685.1 Integration of energy metabolism INTERLEUKIN-10 SIGNALING%REACTOME DATABASE ID RELEASE 66%10145687 Interleukin-10 signaling MITOTIC ANAPHASE%REACTOME DATABASE ID RELEASE 66%10145224 Mitotic Anaphase ZINC EFFLUX AND COMPARTMENTALIZATION BY THE SLC30 FAMILY%REACTOME DATABASE ID RELEASE 66%10145653 Zinc efflux and compartmentalization by the SLC30 family GABA A RECEPTOR ACTIVATION%REACTOME%R-RNO-977441.1 GABA A receptor activation INTESTINAL ABSORPTION%REACTOME DATABASE ID RELEASE 66%10145282 Intestinal absorption DEADENYLATION-DEPENDENT MRNA DECAY%REACTOME%R-RNO-429914.1 Deadenylation-dependent mRNA decay EPH-EPHRIN MEDIATED REPULSION OF CELLS%REACTOME%R-RNO-3928665.1 EPH-ephrin mediated repulsion of cells ADRENALINE SIGNALLING THROUGH ALPHA-2 ADRENERGIC RECEPTOR%REACTOME DATABASE ID RELEASE 66%10145560 Adrenaline signalling through Alpha-2 adrenergic receptor MINERALOCORTICOID BIOSYNTHESIS%REACTOME%R-RNO-193993.1 Mineralocorticoid biosynthesis BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 66%10144858 Base Excision Repair INTERLEUKIN-2 FAMILY SIGNALING%REACTOME DATABASE ID RELEASE 66%10145686 Interleukin-2 family signaling POST-TRANSLATIONAL PROTEIN PHOSPHORYLATION%REACTOME DATABASE ID RELEASE 66%10146280 Post-translational protein phosphorylation CELLULAR RESPONSES TO STRESS%REACTOME%R-RNO-2262752.1 Cellular responses to stress RECYCLING OF BILE ACIDS AND SALTS%REACTOME%R-RNO-159418.1 Recycling of bile acids and salts METAL ION SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 66%10145650 Metal ion SLC transporters UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D%REACTOME%R-RNO-75815.1 Ubiquitin-dependent degradation of Cyclin D SIGNALING BY FGFR4%REACTOME DATABASE ID RELEASE 66%10145262 Signaling by FGFR4 SODIUM CALCIUM EXCHANGERS%REACTOME DATABASE ID RELEASE 66%10145617 Sodium Calcium exchangers POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE%REACTOME%R-RNO-174411.1 Polymerase switching on the C-strand of the telomere INTERLEUKIN RECEPTOR SHC SIGNALING%REACTOME%R-RNO-912526.1 Interleukin receptor SHC signaling REGULATION OF KIT SIGNALING%REACTOME%R-RNO-1433559.1 Regulation of KIT signaling TRAF6 MEDIATED NF-KB ACTIVATION%REACTOME%R-RNO-933542.1 TRAF6 mediated NF-kB activation REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS%REACTOME%R-RNO-450531.1 Regulation of mRNA stability by proteins that bind AU-rich elements ANDROGEN BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 66%10145322 Androgen biosynthesis ACYL CHAIN REMODELLING OF PI%REACTOME%R-RNO-1482922.1 Acyl chain remodelling of PI GLUCURONIDATION%REACTOME%R-RNO-156588.1 Glucuronidation SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS%REACTOME%R-RNO-446219.1 Synthesis of substrates in N-glycan biosythesis FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION%REACTOME%R-RNO-983231.1 Factors involved in megakaryocyte development and platelet production MRNA SPLICING%REACTOME DATABASE ID RELEASE 66%10144829 mRNA Splicing FRUCTOSE CATABOLISM%REACTOME%R-RNO-70350.1 Fructose catabolism METABOLISM OF FAT-SOLUBLE VITAMINS%REACTOME DATABASE ID RELEASE 66%10145778 Metabolism of fat-soluble vitamins NGF PROCESSING%REACTOME DATABASE ID RELEASE 66%10145269 NGF processing BETA-CATENIN PHOSPHORYLATION CASCADE%REACTOME%R-RNO-196299.1 Beta-catenin phosphorylation cascade SYNDECAN INTERACTIONS%REACTOME%R-RNO-3000170.1 Syndecan interactions MET RECEPTOR RECYCLING%REACTOME DATABASE ID RELEASE 66%10146253 MET receptor recycling IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX%REACTOME DATABASE ID RELEASE 66%10144904 Import of palmitoyl-CoA into the mitochondrial matrix COSTIMULATION BY THE CD28 FAMILY%REACTOME DATABASE ID RELEASE 66%10145355 Costimulation by the CD28 family G1 S TRANSITION%REACTOME DATABASE ID RELEASE 66%10144724 G1 S Transition PHOSPHO-PLA2 PATHWAY%REACTOME DATABASE ID RELEASE 66%10144988 phospho-PLA2 pathway NRAGE SIGNALS DEATH THROUGH JNK%REACTOME%R-RNO-193648.1 NRAGE signals death through JNK HDR THROUGH HOMOLOGOUS RECOMBINATION (HRR)%REACTOME%R-RNO-5685942.1 HDR through Homologous Recombination (HRR) N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE%REACTOME%R-RNO-532668.1 N-glycan trimming in the ER and Calnexin Calreticulin cycle IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL%REACTOME%R-RNO-198933.1 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell GAMMA-CARBOXYLATION, TRANSPORT, AND AMINO-TERMINAL CLEAVAGE OF PROTEINS%REACTOME DATABASE ID RELEASE 66%10145094 Gamma-carboxylation, transport, and amino-terminal cleavage of proteins NOTCH4 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME DATABASE ID RELEASE 66%10146329 NOTCH4 Activation and Transmission of Signal to the Nucleus PHOSPHATE BOND HYDROLYSIS BY NUDT PROTEINS%REACTOME DATABASE ID RELEASE 66%10145964 Phosphate bond hydrolysis by NUDT proteins NON-INTEGRIN MEMBRANE-ECM INTERACTIONS%REACTOME DATABASE ID RELEASE 66%10145963 Non-integrin membrane-ECM interactions MITOTIC METAPHASE ANAPHASE TRANSITION%REACTOME DATABASE ID RELEASE 66%10145108 Mitotic Metaphase Anaphase Transition CILIUM ASSEMBLY%REACTOME DATABASE ID RELEASE 66%10146080 Cilium Assembly BETA OXIDATION OF MYRISTOYL-COA TO LAUROYL-COA%REACTOME%R-RNO-77285.1 Beta oxidation of myristoyl-CoA to lauroyl-CoA CELLULAR HEXOSE TRANSPORT%REACTOME%R-RNO-189200.1 Cellular hexose transport CARGO CONCENTRATION IN THE ER%REACTOME DATABASE ID RELEASE 66%10146150 Cargo concentration in the ER BIOSYNTHESIS OF SPECIALIZED PRORESOLVING MEDIATORS (SPMS)%REACTOME%R-RNO-9018678.1 Biosynthesis of specialized proresolving mediators (SPMs) DOWNSTREAM SIGNALING OF ACTIVATED FGFR3%REACTOME%R-RNO-5654708.1 Downstream signaling of activated FGFR3 BIOSYNTHESIS OF DHA-DERIVED SULFIDO CONJUGATES%REACTOME%R-RNO-9026395.1 Biosynthesis of DHA-derived sulfido conjugates LOCALIZATION OF THE PINCH-ILK-PARVIN COMPLEX TO FOCAL ADHESIONS%REACTOME%R-RNO-446343.1 Localization of the PINCH-ILK-PARVIN complex to focal adhesions ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT)%REACTOME%R-RNO-917729.1 Endosomal Sorting Complex Required For Transport (ESCRT) MAPK3 (ERK1) ACTIVATION%REACTOME%R-RNO-110056.1 MAPK3 (ERK1) activation PEPTIDE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145486 Peptide ligand-binding receptors BIOSYNTHESIS OF EPA-DERIVED SPMS%REACTOME%R-RNO-9018679.1 Biosynthesis of EPA-derived SPMs HORMONE LIGAND-BINDING RECEPTORS%REACTOME%R-RNO-375281.1 Hormone ligand-binding receptors BIOSYNTHESIS OF DPA-DERIVED SPMS%REACTOME%R-RNO-9018683.1 Biosynthesis of DPA-derived SPMs SIGNALING BY PTK6%REACTOME%R-RNO-8848021.1 Signaling by PTK6 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%R-RNO-975144.1 IRAK1 recruits IKK complex upon TLR7 8 or 9 stimulation ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS%REACTOME%R-RNO-390471.1 Association of TriC CCT with target proteins during biosynthesis NCAM SIGNALING FOR NEURITE OUT-GROWTH%REACTOME DATABASE ID RELEASE 66%10145367 NCAM signaling for neurite out-growth DOWNSTREAM SIGNAL TRANSDUCTION%REACTOME%R-RNO-186763.1 Downstream signal transduction HDR THROUGH HOMOLOGOUS RECOMBINATION (HRR) OR SINGLE STRAND ANNEALING (SSA)%REACTOME%R-RNO-5693567.1 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) NITRIC OXIDE STIMULATES GUANYLATE CYCLASE%REACTOME DATABASE ID RELEASE 66%10145601 Nitric oxide stimulates guanylate cyclase ER QUALITY CONTROL COMPARTMENT (ERQC)%REACTOME DATABASE ID RELEASE 66%10145712 ER Quality Control Compartment (ERQC) TRAFFICKING OF AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145593 Trafficking of AMPA receptors GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE%REACTOME%R-RNO-210500.1 Glutamate Neurotransmitter Release Cycle RAP1 SIGNALLING%REACTOME DATABASE ID RELEASE 66%10145480 Rap1 signalling MISMATCH REPAIR (MMR) DIRECTED BY MSH2:MSH6 (MUTSALPHA)%REACTOME DATABASE ID RELEASE 66%10146059 Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) INTERLEUKIN-36 PATHWAY%REACTOME%R-RNO-9014826.1 Interleukin-36 pathway SYNTHESIS OF PG%REACTOME%R-RNO-1483148.1 Synthesis of PG SYNTHESIS OF PI%REACTOME%R-RNO-1483226.1 Synthesis of PI SYNTHESIS OF ACTIVE UBIQUITIN: ROLES OF E1 AND E2 ENZYMES%REACTOME DATABASE ID RELEASE 66%10146214 Synthesis of active ubiquitin: roles of E1 and E2 enzymes CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE%REACTOME%R-RNO-442720.1 CREB phosphorylation through the activation of Adenylate Cyclase TNFR1-INDUCED NFKAPPAB SIGNALING PATHWAY%REACTOME DATABASE ID RELEASE 66%10146055 TNFR1-induced NFkappaB signaling pathway BIOSYNTHESIS OF MARESIN-LIKE SPMS%REACTOME DATABASE ID RELEASE 66%10146318 Biosynthesis of maresin-like SPMs CONJUGATION OF BENZOATE WITH GLYCINE%REACTOME%R-RNO-177135.1 Conjugation of benzoate with glycine ABC-FAMILY PROTEINS MEDIATED TRANSPORT%REACTOME DATABASE ID RELEASE 66%10145462 ABC-family proteins mediated transport TRANSPORT OF GLYCEROL FROM ADIPOCYTES TO THE LIVER BY AQUAPORINS%REACTOME DATABASE ID RELEASE 66%10145643 Transport of glycerol from adipocytes to the liver by Aquaporins DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE%REACTOME%R-RNO-606279.1 Deposition of new CENPA-containing nucleosomes at the centromere INTERCONVERSION OF 2-OXOGLUTARATE AND 2-HYDROXYGLUTARATE%REACTOME%R-RNO-880009.1 Interconversion of 2-oxoglutarate and 2-hydroxyglutarate HS-GAG DEGRADATION%REACTOME%R-RNO-2024096.1 HS-GAG degradation GABA B RECEPTOR ACTIVATION%REACTOME%R-RNO-977444.1 GABA B receptor activation GLYCEROPHOSPHOLIPID CATABOLISM%REACTOME DATABASE ID RELEASE 66%10146195 Glycerophospholipid catabolism PI3K AKT SIGNALING%REACTOME%R-RNO-1257604.1 PI3K AKT Signaling SUMOYLATION OF TRANSCRIPTION FACTORS%REACTOME%R-RNO-3232118.1 SUMOylation of transcription factors M PHASE%REACTOME%R-RNO-68886.1 M Phase ACTIVATION OF BID AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%R-RNO-75108.1 Activation of BID and translocation to mitochondria FGFR1C AND KLOTHO LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 66%10145295 FGFR1c and Klotho ligand binding and activation INTRAFLAGELLAR TRANSPORT%REACTOME%R-RNO-5620924.1 Intraflagellar transport BETA OXIDATION OF PALMITOYL-COA TO MYRISTOYL-COA%REACTOME DATABASE ID RELEASE 66%10144934 Beta oxidation of palmitoyl-CoA to myristoyl-CoA SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE%REACTOME DATABASE ID RELEASE 66%10145902 Synthesis of PIPs at the early endosome membrane RNA POLYMERASE II TRANSCRIPTION ELONGATION%REACTOME%R-RNO-75955.1 RNA Polymerase II Transcription Elongation TOLL LIKE RECEPTOR 5 (TLR5) CASCADE%REACTOME DATABASE ID RELEASE 66%10145157 Toll Like Receptor 5 (TLR5) Cascade GLUCOCORTICOID BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 66%10145323 Glucocorticoid biosynthesis REACTIONS SPECIFIC TO THE COMPLEX N-GLYCAN SYNTHESIS PATHWAY%REACTOME DATABASE ID RELEASE 66%10145779 Reactions specific to the complex N-glycan synthesis pathway SIGNALING BY INTERLEUKINS%REACTOME DATABASE ID RELEASE 66%10145163 Signaling by Interleukins DETOXIFICATION OF REACTIVE OXYGEN SPECIES%REACTOME%R-RNO-3299685.1 Detoxification of Reactive Oxygen Species PLASMA LIPOPROTEIN CLEARANCE%REACTOME%R-RNO-8964043.1 Plasma lipoprotein clearance PEROXISOMAL LIPID METABOLISM%REACTOME%R-RNO-390918.1 Peroxisomal lipid metabolism GAP JUNCTION ASSEMBLY%REACTOME%R-RNO-190861.1 Gap junction assembly DNA DAMAGE RECOGNITION IN GG-NER%REACTOME DATABASE ID RELEASE 66%10146144 DNA Damage Recognition in GG-NER MITOTIC METAPHASE AND ANAPHASE%REACTOME DATABASE ID RELEASE 66%10145109 Mitotic Metaphase and Anaphase POST NMDA RECEPTOR ACTIVATION EVENTS%REACTOME%R-RNO-438064.1 Post NMDA receptor activation events MAP KINASE ACTIVATION%REACTOME DATABASE ID RELEASE 66%10145160 MAP kinase activation NUCLEOBASE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 66%10144842 Nucleobase biosynthesis MITOCHONDRIAL TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 66%10145689 Mitochondrial tRNA aminoacylation PI3K AKT ACTIVATION%REACTOME DATABASE ID RELEASE 66%10145352 PI3K AKT activation PTK6 REGULATES PROTEINS INVOLVED IN RNA PROCESSING%REACTOME DATABASE ID RELEASE 66%10146207 PTK6 Regulates Proteins Involved in RNA Processing CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE%REACTOME%R-RNO-204998.1 Cell death signalling via NRAGE, NRIF and NADE SELENOAMINO ACID METABOLISM%REACTOME%R-RNO-2408522.1 Selenoamino acid metabolism CELL CYCLE CHECKPOINTS%REACTOME DATABASE ID RELEASE 66%10144741 Cell Cycle Checkpoints NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC)%REACTOME%R-RNO-975957.1 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) INTERLEUKIN-18 SIGNALING%REACTOME%R-RNO-9012546.1 Interleukin-18 signaling FRS-MEDIATED FGFR2 SIGNALING%REACTOME DATABASE ID RELEASE 66%10146103 FRS-mediated FGFR2 signaling BASE-EXCISION REPAIR, AP SITE FORMATION%REACTOME%R-RNO-73929.1 Base-Excision Repair, AP Site Formation RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER%REACTOME DATABASE ID RELEASE 66%10144947 RNA Polymerase III Transcription Initiation From Type 2 Promoter CYP2E1 REACTIONS%REACTOME%R-RNO-211999.1 CYP2E1 reactions TRANSLATION INITIATION COMPLEX FORMATION%REACTOME DATABASE ID RELEASE 66%10145076 Translation initiation complex formation UNBLOCKING OF NMDA RECEPTORS, GLUTAMATE BINDING AND ACTIVATION%REACTOME%R-RNO-438066.1 Unblocking of NMDA receptors, glutamate binding and activation CAMK IV-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%R-RNO-111932.1 CaMK IV-mediated phosphorylation of CREB LYSOSPHINGOLIPID AND LPA RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145608 Lysosphingolipid and LPA receptors METABOLISM OF INGESTED SEMET, SEC, MESEC INTO H2SE%REACTOME%R-RNO-2408508.1 Metabolism of ingested SeMet, Sec, MeSec into H2Se GLYCOSAMINOGLYCAN METABOLISM%REACTOME%R-RNO-1630316.1 Glycosaminoglycan metabolism RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 66%10144983 Resolution of AP sites via the multiple-nucleotide patch replacement pathway IGF1R SIGNALING CASCADE%REACTOME%R-RNO-2428924.1 IGF1R signaling cascade CELLULAR RESPONSES TO EXTERNAL STIMULI%REACTOME%R-RNO-8953897.1 Cellular responses to external stimuli CHYLOMICRON CLEARANCE%REACTOME%R-RNO-8964026.1 Chylomicron clearance HIGHLY SODIUM PERMEABLE ACETYLCHOLINE NICOTINIC RECEPTORS%REACTOME%R-RNO-629587.1 Highly sodium permeable acetylcholine nicotinic receptors NEGATIVE REGULATION OF MAPK PATHWAY%REACTOME%R-RNO-5675221.1 Negative regulation of MAPK pathway SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE%REACTOME DATABASE ID RELEASE 66%10145899 Synthesis of PIPs at the late endosome membrane ACETYLCHOLINE REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 66%10145585 Acetylcholine regulates insulin secretion RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS%REACTOME%R-RNO-674695.1 RNA Polymerase II Pre-transcription Events REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA)%REACTOME DATABASE ID RELEASE 66%10145590 Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) CONJUGATION OF SALICYLATE WITH GLYCINE%REACTOME%R-RNO-177128.1 Conjugation of salicylate with glycine CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY%REACTOME DATABASE ID RELEASE 66%10145212 Cyclin A:Cdk2-associated events at S phase entry NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 66%10145513 Nuclear Receptor transcription pathway AURKA ACTIVATION BY TPX2%REACTOME%R-RNO-8854518.1 AURKA Activation by TPX2 FATTY ACIDS%REACTOME%R-RNO-211935.1 Fatty acids MITOTIC PROPHASE%REACTOME DATABASE ID RELEASE 66%10145525 Mitotic Prophase THE RETINOID CYCLE IN CONES (DAYLIGHT VISION)%REACTOME DATABASE ID RELEASE 66%10145969 The retinoid cycle in cones (daylight vision) TERMINATION OF O-GLYCAN BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 66%10145784 Termination of O-glycan biosynthesis GLYCOGEN METABOLISM%REACTOME DATABASE ID RELEASE 66%10144770 Glycogen metabolism INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES%REACTOME%R-RNO-499943.1 Interconversion of nucleotide di- and triphosphates N-GLYCAN ANTENNAE ELONGATION%REACTOME DATABASE ID RELEASE 66%10145781 N-Glycan antennae elongation O-LINKED GLYCOSYLATION%REACTOME%R-RNO-5173105.1 O-linked glycosylation DNA REPLICATION INITIATION%REACTOME DATABASE ID RELEASE 66%10144718 DNA replication initiation PURINE SALVAGE%REACTOME DATABASE ID RELEASE 66%10144873 Purine salvage G-PROTEIN BETA:GAMMA SIGNALLING%REACTOME%R-RNO-397795.1 G-protein beta:gamma signalling ALTERNATIVE COMPLEMENT ACTIVATION%REACTOME DATABASE ID RELEASE 66%10145211 Alternative complement activation SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP)%REACTOME DATABASE ID RELEASE 66%10145264 Senescence-Associated Secretory Phenotype (SASP) SIGNALING BY INSULIN RECEPTOR%REACTOME%R-RNO-74752.1 Signaling by Insulin receptor SIGNALING BY NODAL%REACTOME%R-RNO-1181150.1 Signaling by NODAL PI3K EVENTS IN ERBB2 SIGNALING%REACTOME DATABASE ID RELEASE 66%10145823 PI3K events in ERBB2 signaling U12 DEPENDENT SPLICING%REACTOME%R-RNO-72165.1 U12 Dependent Splicing RHO GTPASES ACTIVATE PKNS%REACTOME%R-RNO-5625740.1 RHO GTPases activate PKNs C6 DEAMINATION OF ADENOSINE%REACTOME%R-RNO-75102.1 C6 deamination of adenosine SERINE BIOSYNTHESIS%REACTOME%R-RNO-977347.1 Serine biosynthesis NEGATIVE REGULATION OF THE PI3K AKT NETWORK%REACTOME%R-RNO-199418.1 Negative regulation of the PI3K AKT network METABOLISM OF FOLATE AND PTERINES%REACTOME%R-RNO-196757.1 Metabolism of folate and pterines ACTIVATION OF C3 AND C5%REACTOME%R-RNO-174577.1 Activation of C3 and C5 SHC-MEDIATED CASCADE:FGFR3%REACTOME%R-RNO-5654704.1 SHC-mediated cascade:FGFR3 BIOLOGICAL OXIDATIONS%REACTOME%R-RNO-211859.1 Biological oxidations NONCANONICAL ACTIVATION OF NOTCH3%REACTOME%R-RNO-9017802.1 Noncanonical activation of NOTCH3 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION)%REACTOME%R-RNO-2453902.1 The canonical retinoid cycle in rods (twilight vision) REGULATION OF TNFR1 SIGNALING%REACTOME DATABASE ID RELEASE 66%10146056 Regulation of TNFR1 signaling RNA POLYMERASE II PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 66%10144902 RNA Polymerase II Promoter Escape SUMOYLATION OF DNA METHYLATION PROTEINS%REACTOME%R-RNO-4655427.1 SUMOylation of DNA methylation proteins RUNX1 REGULATES ESTROGEN RECEPTOR MEDIATED TRANSCRIPTION%REACTOME DATABASE ID RELEASE 66%10146262 RUNX1 regulates estrogen receptor mediated transcription THREONINE CATABOLISM%REACTOME DATABASE ID RELEASE 66%10146296 Threonine catabolism METABOLISM OF RNA%REACTOME DATABASE ID RELEASE 66%10144827 Metabolism of RNA SYNTHESIS OF DOLICHYL-PHOSPHATE MANNOSE%REACTOME DATABASE ID RELEASE 66%10145103 Synthesis of dolichyl-phosphate mannose RNA POLYMERASE III TRANSCRIPTION INITIATION%REACTOME%R-RNO-76046.1 RNA Polymerase III Transcription Initiation ADENOSINE P1 RECEPTORS%REACTOME%R-RNO-417973.1 Adenosine P1 receptors WAX BIOSYNTHESIS%REACTOME%R-RNO-8848584.1 Wax biosynthesis ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 66%10145451 Acetylcholine Neurotransmitter Release Cycle TRAIL SIGNALING%REACTOME%R-RNO-75158.1 TRAIL signaling DIGESTION%REACTOME DATABASE ID RELEASE 66%10145278 Digestion CELLULAR SENESCENCE%REACTOME%R-RNO-2559583.1 Cellular Senescence G ALPHA (S) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 66%10145517 G alpha (s) signalling events TNFR1-MEDIATED CERAMIDE PRODUCTION%REACTOME DATABASE ID RELEASE 66%10146089 TNFR1-mediated ceramide production SIGNALING BY RETINOIC ACID%REACTOME DATABASE ID RELEASE 66%10145381 Signaling by Retinoic Acid DIMERIZATION OF PROCASPASE-8%REACTOME%R-RNO-69416.1 Dimerization of procaspase-8 REGULATION OF GAP JUNCTION ACTIVITY%REACTOME DATABASE ID RELEASE 66%10145308 Regulation of gap junction activity PROLONGED ERK ACTIVATION EVENTS%REACTOME DATABASE ID RELEASE 66%10145181 Prolonged ERK activation events RELEASE OF APOPTOTIC FACTORS FROM THE MITOCHONDRIA%REACTOME DATABASE ID RELEASE 66%10145018 Release of apoptotic factors from the mitochondria SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE%REACTOME%R-RNO-1660499.1 Synthesis of PIPs at the plasma membrane TRANSPORT AND SYNTHESIS OF PAPS%REACTOME%R-RNO-174362.1 Transport and synthesis of PAPS DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING%REACTOME DATABASE ID RELEASE 66%10145207 Downregulation of TGF-beta receptor signaling SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI)%REACTOME%R-RNO-162710.1 Synthesis of glycosylphosphatidylinositol (GPI) INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS%REACTOME%R-RNO-997272.1 Inhibition of voltage gated Ca2+ channels via Gbeta gamma subunits PROTON-COUPLED NEUTRAL AMINO ACID TRANSPORTERS%REACTOME DATABASE ID RELEASE 66%10145510 Proton-coupled neutral amino acid transporters ERYTHROPOIETIN ACTIVATES PHOSPHOINOSITIDE-3-KINASE (PI3K)%REACTOME DATABASE ID RELEASE 66%10146294 Erythropoietin activates Phosphoinositide-3-kinase (PI3K) METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS%REACTOME DATABASE ID RELEASE 66%10145925 Metabolism of Angiotensinogen to Angiotensins ION CHANNEL TRANSPORT%REACTOME DATABASE ID RELEASE 66%10145600 Ion channel transport CREB3 FACTORS ACTIVATE GENES%REACTOME DATABASE ID RELEASE 66%10146248 CREB3 factors activate genes ORC1 REMOVAL FROM CHROMATIN%REACTOME%R-RNO-68949.1 Orc1 removal from chromatin SIGNALING BY FGFR2%REACTOME DATABASE ID RELEASE 66%10145256 Signaling by FGFR2 AMINE OXIDASE REACTIONS%REACTOME DATABASE ID RELEASE 66%10145056 Amine Oxidase reactions TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION%REACTOME%R-RNO-948021.1 Transport to the Golgi and subsequent modification L1CAM INTERACTIONS%REACTOME DATABASE ID RELEASE 66%10144965 L1CAM interactions PROLACTIN RECEPTOR SIGNALING%REACTOME DATABASE ID RELEASE 66%10145783 Prolactin receptor signaling ACETYLATION%REACTOME DATABASE ID RELEASE 66%10145083 Acetylation CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII%REACTOME DATABASE ID RELEASE 66%10145658 CREB phosphorylation through the activation of CaMKII FORMATION OF XYLULOSE-5-PHOSPHATE%REACTOME DATABASE ID RELEASE 66%10146116 Formation of xylulose-5-phosphate BETA DEFENSINS%REACTOME DATABASE ID RELEASE 66%10145858 Beta defensins GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY%REACTOME%R-RNO-399721.1 Glutamate binding, activation of AMPA receptors and synaptic plasticity STRIATED MUSCLE CONTRACTION%REACTOME%R-RNO-390522.1 Striated Muscle Contraction ABC TRANSPORTERS IN LIPID HOMEOSTASIS%REACTOME DATABASE ID RELEASE 66%10145461 ABC transporters in lipid homeostasis RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF MYELOID CELLS%REACTOME DATABASE ID RELEASE 66%10146266 RUNX1 regulates transcription of genes involved in differentiation of myeloid cells ESR-MEDIATED SIGNALING%REACTOME DATABASE ID RELEASE 66%10145830 ESR-mediated signaling G ALPHA (Q) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 66%10145036 G alpha (q) signalling events PI3K EVENTS IN ERBB4 SIGNALING%REACTOME%R-RNO-1250342.1 PI3K events in ERBB4 signaling CGMP EFFECTS%REACTOME%R-RNO-418457.1 cGMP effects INTERACTION BETWEEN PHLDA1 AND AURKA%REACTOME DATABASE ID RELEASE 66%10146219 Interaction between PHLDA1 and AURKA G-PROTEIN MEDIATED EVENTS%REACTOME%R-RNO-112040.1 G-protein mediated events ERBB2 REGULATES CELL MOTILITY%REACTOME DATABASE ID RELEASE 66%10146156 ERBB2 Regulates Cell Motility S PHASE%REACTOME%R-RNO-69242.1 S Phase IL-6-TYPE CYTOKINE RECEPTOR LIGAND INTERACTIONS%REACTOME DATABASE ID RELEASE 66%10145682 IL-6-type cytokine receptor ligand interactions VESICLE-MEDIATED TRANSPORT%REACTOME DATABASE ID RELEASE 66%10145300 Vesicle-mediated transport CONJUGATION OF PHENYLACETATE WITH GLUTAMINE%REACTOME DATABASE ID RELEASE 66%10145246 Conjugation of phenylacetate with glutamine SIGNALING BY FGFR1%REACTOME%R-RNO-5654736.1 Signaling by FGFR1 RNA POLYMERASE I CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 66%10144884 RNA Polymerase I Chain Elongation INTERLEUKIN-17 SIGNALING%REACTOME%R-RNO-448424.1 Interleukin-17 signaling HDMS DEMETHYLATE HISTONES%REACTOME DATABASE ID RELEASE 66%10145998 HDMs demethylate histones RNA POLYMERASE I TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 66%10144850 RNA Polymerase I Transcription Initiation SCAVENGING OF HEME FROM PLASMA%REACTOME%R-RNO-2168880.1 Scavenging of heme from plasma MAP3K8 (TPL2)-DEPENDENT MAPK1 3 ACTIVATION%REACTOME DATABASE ID RELEASE 66%10145702 MAP3K8 (TPL2)-dependent MAPK1 3 activation SYNTHESIS OF 5-EICOSATETRAENOIC ACIDS%REACTOME%R-RNO-2142688.1 Synthesis of 5-eicosatetraenoic acids MYOGENESIS%REACTOME%R-RNO-525793.1 Myogenesis CHONDROITIN SULFATE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 66%10145919 Chondroitin sulfate biosynthesis SIGNALING BY LEPTIN%REACTOME DATABASE ID RELEASE 66%10145709 Signaling by Leptin ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1%REACTOME DATABASE ID RELEASE 66%10145597 ADP signalling through P2Y purinoceptor 1 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE%REACTOME%R-RNO-2559586.1 DNA Damage Telomere Stress Induced Senescence FATTY ACYL-COA BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 66%10144901 Fatty acyl-CoA biosynthesis P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME%R-RNO-69580.1 p53-Dependent G1 S DNA damage checkpoint RSK ACTIVATION%REACTOME DATABASE ID RELEASE 66%10145660 RSK activation PROCESSING OF CAPPED INTRONLESS PRE-MRNA%REACTOME%R-RNO-75067.1 Processing of Capped Intronless Pre-mRNA DUAL INCISION IN GG-NER%REACTOME DATABASE ID RELEASE 66%10146140 Dual Incision in GG-NER CONDENSATION OF PROPHASE CHROMOSOMES%REACTOME DATABASE ID RELEASE 66%10145955 Condensation of Prophase Chromosomes REGULATION OF TP53 ACTIVITY%REACTOME%R-RNO-5633007.1 Regulation of TP53 Activity MICROTUBULE-DEPENDENT TRAFFICKING OF CONNEXONS FROM GOLGI TO THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 66%10145301 Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane ER TO GOLGI ANTEROGRADE TRANSPORT%REACTOME%R-RNO-199977.1 ER to Golgi Anterograde Transport IRON UPTAKE AND TRANSPORT%REACTOME DATABASE ID RELEASE 66%10145283 Iron uptake and transport CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION%REACTOME DATABASE ID RELEASE 66%10145415 Class I MHC mediated antigen processing & presentation POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%R-RNO-622327.1 Postsynaptic nicotinic acetylcholine receptors INTERLEUKIN-15 SIGNALING%REACTOME%R-RNO-8983432.1 Interleukin-15 signaling CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE%REACTOME%R-RNO-176407.1 Conversion from APC C:Cdc20 to APC C:Cdh1 in late anaphase ACTIVATED NTRK2 SIGNALS THROUGH FYN%REACTOME DATABASE ID RELEASE 66%10146323 Activated NTRK2 signals through FYN MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF SATURATED FATTY ACIDS%REACTOME%R-RNO-77286.1 mitochondrial fatty acid beta-oxidation of saturated fatty acids MET ACTIVATES RAP1 AND RAC1%REACTOME DATABASE ID RELEASE 66%10146252 MET activates RAP1 and RAC1 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION%REACTOME%R-RNO-156827.1 L13a-mediated translational silencing of Ceruloplasmin expression HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME%R-RNO-5693579.1 Homologous DNA Pairing and Strand Exchange P75NTR SIGNALS VIA NF-KB%REACTOME%R-RNO-193639.1 p75NTR signals via NF-kB CELL-CELL COMMUNICATION%REACTOME DATABASE ID RELEASE 66%10145431 Cell-Cell communication RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASES%REACTOME DATABASE ID RELEASE 66%10145543 Receptor-type tyrosine-protein phosphatases SULFIDE OXIDATION TO SULFATE%REACTOME DATABASE ID RELEASE 66%10145889 Sulfide oxidation to sulfate SIGNALING BY EGFR%REACTOME DATABASE ID RELEASE 66%10144957 Signaling by EGFR INVADOPODIA FORMATION%REACTOME DATABASE ID RELEASE 66%10146271 Invadopodia formation P53-DEPENDENT G1 DNA DAMAGE RESPONSE%REACTOME%R-RNO-69563.1 p53-Dependent G1 DNA Damage Response METAL SEQUESTRATION BY ANTIMICROBIAL PROTEINS%REACTOME DATABASE ID RELEASE 66%10145804 Metal sequestration by antimicrobial proteins SUMOYLATION OF IMMUNE RESPONSE PROTEINS%REACTOME%R-RNO-4755510.1 SUMOylation of immune response proteins LYSINE CATABOLISM%REACTOME%R-RNO-71064.1 Lysine catabolism ARL13B-MEDIATED CILIARY TRAFFICKING OF INPP5E%REACTOME DATABASE ID RELEASE 66%10146085 ARL13B-mediated ciliary trafficking of INPP5E TRANSPORT OF FATTY ACIDS%REACTOME%R-RNO-804914.1 Transport of fatty acids COPI-DEPENDENT GOLGI-TO-ER RETROGRADE TRAFFIC%REACTOME%R-RNO-6811434.1 COPI-dependent Golgi-to-ER retrograde traffic METABOLISM OF PROTEINS%REACTOME DATABASE ID RELEASE 66%10144825 Metabolism of proteins IRF3-MEDIATED INDUCTION OF TYPE I IFN%REACTOME DATABASE ID RELEASE 66%10145930 IRF3-mediated induction of type I IFN REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION%REACTOME%R-RNO-2565942.1 Regulation of PLK1 Activity at G2 M Transition INTERLEUKIN-33 SIGNALING%REACTOME%R-RNO-9014843.1 Interleukin-33 signaling MHC CLASS II ANTIGEN PRESENTATION%REACTOME DATABASE ID RELEASE 66%10145936 MHC class II antigen presentation DNA REPLICATION%REACTOME%R-RNO-69306.1 DNA Replication ARYL HYDROCARBON RECEPTOR SIGNALLING%REACTOME DATABASE ID RELEASE 66%10146264 Aryl hydrocarbon receptor signalling ISG15 ANTIVIRAL MECHANISM%REACTOME DATABASE ID RELEASE 66%10145800 ISG15 antiviral mechanism GENERIC TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 66%10144749 Generic Transcription Pathway ACYL CHAIN REMODELING OF CL%REACTOME%R-RNO-1482798.1 Acyl chain remodeling of CL VOLTAGE GATED POTASSIUM CHANNELS%REACTOME DATABASE ID RELEASE 66%10145837 Voltage gated Potassium channels ADHERENS JUNCTIONS INTERACTIONS%REACTOME DATABASE ID RELEASE 66%10145606 Adherens junctions interactions BETA-OXIDATION OF PRISTANOYL-COA%REACTOME%R-RNO-389887.1 Beta-oxidation of pristanoyl-CoA SEMA4D IN SEMAPHORIN SIGNALING%REACTOME%R-RNO-400685.1 Sema4D in semaphorin signaling TRANSCRIPTIONAL REGULATION BY E2F6%REACTOME%R-RNO-8953750.1 Transcriptional Regulation by E2F6 SUMOYLATION OF DNA DAMAGE RESPONSE AND REPAIR PROTEINS%REACTOME%R-RNO-3108214.1 SUMOylation of DNA damage response and repair proteins ERK1 ERK2 PATHWAY%REACTOME DATABASE ID RELEASE 66%10144961 ERK1 ERK2 pathway TOLL LIKE RECEPTOR 9 (TLR9) CASCADE%REACTOME DATABASE ID RELEASE 66%10145153 Toll Like Receptor 9 (TLR9) Cascade GLUCAGON SIGNALING IN METABOLIC REGULATION%REACTOME DATABASE ID RELEASE 66%10145003 Glucagon signaling in metabolic regulation ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION%REACTOME DATABASE ID RELEASE 66%10145786 Antigen processing: Ubiquitination & Proteasome degradation GAP JUNCTION TRAFFICKING%REACTOME%R-RNO-190828.1 Gap junction trafficking REGULATION OF PTEN STABILITY AND ACTIVITY%REACTOME DATABASE ID RELEASE 66%10146185 Regulation of PTEN stability and activity EXTRINSIC PATHWAY OF FIBRIN CLOT FORMATION%REACTOME DATABASE ID RELEASE 66%10145054 Extrinsic Pathway of Fibrin Clot Formation MITOCHONDRIAL TRANSLATION ELONGATION%REACTOME DATABASE ID RELEASE 66%10146063 Mitochondrial translation elongation TRANSFER OF LPS FROM LBP CARRIER TO CD14%REACTOME%R-RNO-166020.1 Transfer of LPS from LBP carrier to CD14 ENOS ACTIVATION AND REGULATION%REACTOME%R-RNO-203765.1 eNOS activation and regulation G2 M TRANSITION%REACTOME%R-RNO-69275.1 G2 M Transition SYNTHESIS OF GDP-MANNOSE%REACTOME DATABASE ID RELEASE 66%10145672 Synthesis of GDP-mannose PI-3K CASCADE:FGFR3%REACTOME DATABASE ID RELEASE 66%10145257 PI-3K cascade:FGFR3 PAOS OXIDISE POLYAMINES TO AMINES%REACTOME DATABASE ID RELEASE 66%10145060 PAOs oxidise polyamines to amines DOWNREGULATION OF ERBB4 SIGNALING%REACTOME DATABASE ID RELEASE 66%10145828 Downregulation of ERBB4 signaling REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION%REACTOME%R-RNO-2029482.1 Regulation of actin dynamics for phagocytic cup formation TERMINAL PATHWAY OF COMPLEMENT%REACTOME DATABASE ID RELEASE 66%10145210 Terminal pathway of complement REGULATION OF RUNX1 EXPRESSION AND ACTIVITY%REACTOME%R-RNO-8934593.1 Regulation of RUNX1 Expression and Activity INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%R-RNO-2514859.1 Inactivation, recovery and regulation of the phototransduction cascade GENERATION OF SECOND MESSENGER MOLECULES%REACTOME DATABASE ID RELEASE 66%10145400 Generation of second messenger molecules MITOCHONDRIAL TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 66%10145119 Mitochondrial transcription termination CLEAVAGE OF THE DAMAGED PYRIMIDINE%REACTOME%R-RNO-110329.1 Cleavage of the damaged pyrimidine INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME DATABASE ID RELEASE 66%10145016 Intrinsic Pathway for Apoptosis PHASE 3 - RAPID REPOLARISATION%REACTOME%R-RNO-5576890.1 Phase 3 - rapid repolarisation TRANSLESION SYNTHESIS BY POLH%REACTOME%R-RNO-110320.1 Translesion Synthesis by POLH PLATELET CALCIUM HOMEOSTASIS%REACTOME%R-RNO-418360.1 Platelet calcium homeostasis NUCLEAR ENVELOPE REASSEMBLY%REACTOME%R-RNO-2995410.1 Nuclear Envelope Reassembly DAG AND IP3 SIGNALING%REACTOME%R-RNO-1489509.1 DAG and IP3 signaling ION INFLUX EFFLUX AT HOST-PATHOGEN INTERFACE%REACTOME%R-RNO-6803544.1 Ion influx efflux at host-pathogen interface GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER%REACTOME DATABASE ID RELEASE 66%10146143 Gap-filling DNA repair synthesis and ligation in GG-NER PYRIMIDINE CATABOLISM%REACTOME%R-RNO-73621.1 Pyrimidine catabolism GLYCOLYSIS%REACTOME DATABASE ID RELEASE 66%10144768 Glycolysis MOLECULES ASSOCIATED WITH ELASTIC FIBRES%REACTOME DATABASE ID RELEASE 66%10145882 Molecules associated with elastic fibres OXIDATIVE DEMETHYLATION OF DNA%REACTOME DATABASE ID RELEASE 66%10146048 Oxidative demethylation of DNA TRANSPORT OF CONNEXONS TO THE PLASMA MEMBRANE%REACTOME%R-RNO-190872.1 Transport of connexons to the plasma membrane RRNA PROCESSING%REACTOME DATABASE ID RELEASE 66%10146163 rRNA processing AGMATINE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 66%10145466 Agmatine biosynthesis MUSCARINIC ACETYLCHOLINE RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145559 Muscarinic acetylcholine receptors ACTIVATED NTRK2 SIGNALS THROUGH PLCG1%REACTOME%R-RNO-9026527.1 Activated NTRK2 signals through PLCG1 KETONE BODY METABOLISM%REACTOME DATABASE ID RELEASE 66%10144854 Ketone body metabolism TYPE II NA+ PI COTRANSPORTERS%REACTOME DATABASE ID RELEASE 66%10145628 Type II Na+ Pi cotransporters TRAF3-DEPENDENT IRF ACTIVATION PATHWAY%REACTOME DATABASE ID RELEASE 66%10145795 TRAF3-dependent IRF activation pathway ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX%REACTOME%R-RNO-68867.1 Assembly of the pre-replicative complex SYNTHESIS OF PC%REACTOME DATABASE ID RELEASE 66%10145452 Synthesis of PC HYALURONAN UPTAKE AND DEGRADATION%REACTOME%R-RNO-2160916.1 Hyaluronan uptake and degradation SIGNALING BY NOTCH1%REACTOME DATABASE ID RELEASE 66%10145913 Signaling by NOTCH1 PASSIVE TRANSPORT BY AQUAPORINS%REACTOME DATABASE ID RELEASE 66%10145707 Passive transport by Aquaporins NCAM1 INTERACTIONS%REACTOME DATABASE ID RELEASE 66%10145505 NCAM1 interactions SIALIC ACID METABOLISM%REACTOME DATABASE ID RELEASE 66%10145633 Sialic acid metabolism G1 S DNA DAMAGE CHECKPOINTS%REACTOME DATABASE ID RELEASE 66%10144740 G1 S DNA Damage Checkpoints SODIUM-COUPLED PHOSPHATE COTRANSPORTERS%REACTOME DATABASE ID RELEASE 66%10145627 Sodium-coupled phosphate cotransporters REGULATION OF COMMISSURAL AXON PATHFINDING BY SLIT AND ROBO%REACTOME DATABASE ID RELEASE 66%10145632 Regulation of commissural axon pathfinding by SLIT and ROBO REGULATION OF PTEN LOCALIZATION%REACTOME%R-RNO-8948747.1 Regulation of PTEN localization PHASE II - CONJUGATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 66%10144773 Phase II - Conjugation of compounds TRANSFERRIN ENDOCYTOSIS AND RECYCLING%REACTOME%R-RNO-917977.1 Transferrin endocytosis and recycling NECTIN NECL TRANS HETERODIMERIZATION%REACTOME DATABASE ID RELEASE 66%10145613 Nectin Necl trans heterodimerization REGULATION OF FZD BY UBIQUITINATION%REACTOME DATABASE ID RELEASE 66%10146037 Regulation of FZD by ubiquitination FGFR3B LIGAND BINDING AND ACTIVATION%REACTOME%R-RNO-190371.1 FGFR3b ligand binding and activation ION HOMEOSTASIS%REACTOME DATABASE ID RELEASE 66%10145041 Ion homeostasis DEVELOPMENTAL BIOLOGY%REACTOME DATABASE ID RELEASE 66%10144967 Developmental Biology GPCR DOWNSTREAM SIGNALLING%REACTOME DATABASE ID RELEASE 66%10144869 GPCR downstream signalling PHOSPHATE BOND HYDROLYSIS BY NTPDASE PROTEINS%REACTOME DATABASE ID RELEASE 66%10146210 Phosphate bond hydrolysis by NTPDase proteins ANTAGONISM OF ACTIVIN BY FOLLISTATIN%REACTOME%R-RNO-2473224.1 Antagonism of Activin by Follistatin PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR%REACTOME%R-RNO-392851.1 Prostacyclin signalling through prostacyclin receptor CHOLINE CATABOLISM%REACTOME%R-RNO-6798163.1 Choline catabolism MULTIFUNCTIONAL ANION EXCHANGERS%REACTOME DATABASE ID RELEASE 66%10145626 Multifunctional anion exchangers TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 66%10144823 tRNA Aminoacylation OLFACTORY SIGNALING PATHWAY%REACTOME%R-RNO-381753.1 Olfactory Signaling Pathway VLDLR INTERNALISATION AND DEGRADATION%REACTOME%R-RNO-8866427.1 VLDLR internalisation and degradation BETA OXIDATION OF HEXANOYL-COA TO BUTANOYL-COA%REACTOME%R-RNO-77350.1 Beta oxidation of hexanoyl-CoA to butanoyl-CoA FANCONI ANEMIA PATHWAY%REACTOME%R-RNO-6783310.1 Fanconi Anemia Pathway REGULATION OF TP53 ACTIVITY THROUGH ASSOCIATION WITH CO-FACTORS%REACTOME%R-RNO-6804759.1 Regulation of TP53 Activity through Association with Co-factors CLEC7A (DECTIN-1) INDUCES NFAT ACTIVATION%REACTOME%R-RNO-5607763.1 CLEC7A (Dectin-1) induces NFAT activation GP1B-IX-V ACTIVATION SIGNALLING%REACTOME DATABASE ID RELEASE 66%10145640 GP1b-IX-V activation signalling CATION-COUPLED CHLORIDE COTRANSPORTERS%REACTOME DATABASE ID RELEASE 66%10145620 Cation-coupled Chloride cotransporters FGFRL1 MODULATION OF FGFR1 SIGNALING%REACTOME%R-RNO-5658623.1 FGFRL1 modulation of FGFR1 signaling APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS%REACTOME%R-RNO-111465.1 Apoptotic cleavage of cellular proteins MICRORNA (MIRNA) BIOGENESIS%REACTOME%R-RNO-203927.1 MicroRNA (miRNA) biogenesis STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES%REACTOME%R-RNO-1834941.1 STING mediated induction of host immune responses MEIOTIC RECOMBINATION%REACTOME%R-RNO-912446.1 Meiotic recombination RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF KERATINOCYTES%REACTOME DATABASE ID RELEASE 66%10146265 RUNX1 regulates transcription of genes involved in differentiation of keratinocytes MITOCHONDRIAL PROTEIN IMPORT%REACTOME DATABASE ID RELEASE 66%10146287 Mitochondrial protein import ENZYMATIC DEGRADATION OF DOPAMINE BY MONOAMINE OXIDASE%REACTOME DATABASE ID RELEASE 66%10145518 Enzymatic degradation of Dopamine by monoamine oxidase G ALPHA (Z) SIGNALLING EVENTS%REACTOME%R-RNO-418597.1 G alpha (z) signalling events SURFACTANT METABOLISM%REACTOME DATABASE ID RELEASE 66%10145605 Surfactant metabolism AUTODEGRADATION OF CDH1 BY CDH1:APC C%REACTOME DATABASE ID RELEASE 66%10145213 Autodegradation of Cdh1 by Cdh1:APC C GLYCOPROTEIN HORMONES%REACTOME DATABASE ID RELEASE 66%10145514 Glycoprotein hormones RRNA PROCESSING IN THE NUCLEUS AND CYTOSOL%REACTOME DATABASE ID RELEASE 66%10146162 rRNA processing in the nucleus and cytosol INITIATION OF NUCLEAR ENVELOPE REFORMATION%REACTOME DATABASE ID RELEASE 66%10145989 Initiation of Nuclear Envelope Reformation METABOLISM OF STEROIDS%REACTOME DATABASE ID RELEASE 66%10145088 Metabolism of steroids REGULATION OF GENE EXPRESSION IN BETA CELLS%REACTOME%R-RNO-210745.1 Regulation of gene expression in beta cells ACTIVATION OF BH3-ONLY PROTEINS%REACTOME DATABASE ID RELEASE 66%10145046 Activation of BH3-only proteins EXPRESSION AND PROCESSING OF NEUROTROPHINS%REACTOME%R-RNO-9036866.1 Expression and Processing of Neurotrophins G2 PHASE%REACTOME DATABASE ID RELEASE 66%10145274 G2 Phase CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION%REACTOME%R-RNO-109688.1 Cleavage of Growing Transcript in the Termination Region CA2+ PATHWAY%REACTOME DATABASE ID RELEASE 66%10145578 Ca2+ pathway VITAMIN E%REACTOME DATABASE ID RELEASE 66%10146249 Vitamin E INTRACELLULAR SIGNALING BY SECOND MESSENGERS%REACTOME DATABASE ID RELEASE 66%10144994 Intracellular signaling by second messengers RECEPTOR MEDIATED MITOPHAGY%REACTOME DATABASE ID RELEASE 66%10146273 Receptor Mediated Mitophagy SOS-MEDIATED SIGNALLING%REACTOME%R-RNO-112412.1 SOS-mediated signalling TCF DEPENDENT SIGNALING IN RESPONSE TO WNT%REACTOME%R-RNO-201681.1 TCF dependent signaling in response to WNT OTHER INTERLEUKIN SIGNALING%REACTOME%R-RNO-449836.1 Other interleukin signaling INTRA-GOLGI TRAFFIC%REACTOME DATABASE ID RELEASE 66%10146194 Intra-Golgi traffic GRB2 EVENTS IN ERBB2 SIGNALING%REACTOME DATABASE ID RELEASE 66%10145849 GRB2 events in ERBB2 signaling DAP12 INTERACTIONS%REACTOME%R-RNO-2172127.1 DAP12 interactions ORGANIC ANION TRANSPORT%REACTOME%R-RNO-561048.1 Organic anion transport TRYPTOPHAN CATABOLISM%REACTOME%R-RNO-71240.1 Tryptophan catabolism SYNTHESIS OF LIPOXINS (LX)%REACTOME DATABASE ID RELEASE 66%10145463 Synthesis of Lipoxins (LX) AXONAL GROWTH STIMULATION%REACTOME%R-RNO-209563.1 Axonal growth stimulation SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL%REACTOME%R-RNO-1855183.1 Synthesis of IP2, IP, and Ins in the cytosol RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 66%10144903 RNA Polymerase II Transcription Initiation And Promoter Clearance SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21%REACTOME DATABASE ID RELEASE 66%10145271 SCF(Skp2)-mediated degradation of p27 p21 GLYOXYLATE METABOLISM AND GLYCINE DEGRADATION%REACTOME%R-RNO-389661.1 Glyoxylate metabolism and glycine degradation ERYTHROPOIETIN ACTIVATES RAS%REACTOME DATABASE ID RELEASE 66%10146321 Erythropoietin activates RAS MITOCHONDRIAL UNCOUPLING PROTEINS%REACTOME DATABASE ID RELEASE 66%10145136 Mitochondrial Uncoupling Proteins INTERACTION BETWEEN L1 AND ANKYRINS%REACTOME DATABASE ID RELEASE 66%10145576 Interaction between L1 and Ankyrins REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX%REACTOME%R-RNO-204174.1 Regulation of pyruvate dehydrogenase (PDH) complex ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S%REACTOME%R-RNO-72662.1 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S SYNTHESIS OF DOLICHYL-PHOSPHATE%REACTOME DATABASE ID RELEASE 66%10145306 Synthesis of Dolichyl-phosphate KETONE BODY CATABOLISM%REACTOME%R-RNO-77108.1 Ketone body catabolism REDUCTION OF CYTOSOLIC CA++ LEVELS%REACTOME%R-RNO-418359.1 Reduction of cytosolic Ca++ levels TCR SIGNALING%REACTOME DATABASE ID RELEASE 66%10145376 TCR signaling SUMOYLATION%REACTOME%R-RNO-2990846.1 SUMOylation CALMODULIN INDUCED EVENTS%REACTOME DATABASE ID RELEASE 66%10144991 Calmodulin induced events ACTIVATION OF PKB%REACTOME DATABASE ID RELEASE 66%10144955 Activation of PKB MET ACTIVATES PTK2 SIGNALING%REACTOME DATABASE ID RELEASE 66%10146246 MET activates PTK2 signaling OPIOID SIGNALLING%REACTOME%R-RNO-111885.1 Opioid Signalling SIGNALING BY ERBB2%REACTOME%R-RNO-1227986.1 Signaling by ERBB2 PHASE 0 - RAPID DEPOLARISATION%REACTOME DATABASE ID RELEASE 66%10146067 Phase 0 - rapid depolarisation MISCELLANEOUS SUBSTRATES%REACTOME DATABASE ID RELEASE 66%10145442 Miscellaneous substrates HATS ACETYLATE HISTONES%REACTOME%R-RNO-3214847.1 HATs acetylate histones REGULATION OF IFNA SIGNALING%REACTOME%R-RNO-912694.1 Regulation of IFNA signaling ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES%REACTOME%R-RNO-1169410.1 Antiviral mechanism by IFN-stimulated genes SIGNALING BY NOTCH4%REACTOME DATABASE ID RELEASE 66%10146330 Signaling by NOTCH4 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM%REACTOME DATABASE ID RELEASE 66%10144804 Cobalamin (Cbl, vitamin B12) transport and metabolism ASSEMBLY OF ACTIVE LPL AND LIPC LIPASE COMPLEXES%REACTOME DATABASE ID RELEASE 66%10146149 Assembly of active LPL and LIPC lipase complexes SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX)%REACTOME%R-RNO-2162123.1 Synthesis of Prostaglandins (PG) and Thromboxanes (TX) INTERLEUKIN-38 SIGNALING%REACTOME DATABASE ID RELEASE 66%10146291 Interleukin-38 signaling AUF1 (HNRNP D0) BINDS AND DESTABILIZES MRNA%REACTOME DATABASE ID RELEASE 66%10145697 AUF1 (hnRNP D0) binds and destabilizes mRNA CYTOKINE SIGNALING IN IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 66%10145164 Cytokine Signaling in Immune system FORMATION OF A POOL OF FREE 40S SUBUNITS%REACTOME%R-RNO-72689.1 Formation of a pool of free 40S subunits LRR FLII-INTERACTING PROTEIN 1 (LRRFIP1) ACTIVATES TYPE I IFN PRODUCTION%REACTOME%R-RNO-3134973.1 LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production DISSOLUTION OF FIBRIN CLOT%REACTOME DATABASE ID RELEASE 66%10145082 Dissolution of Fibrin Clot RESOLUTION OF D-LOOP STRUCTURES THROUGH HOLLIDAY JUNCTION INTERMEDIATES%REACTOME%R-RNO-5693568.1 Resolution of D-loop Structures through Holliday Junction Intermediates RETINOID METABOLISM AND TRANSPORT%REACTOME DATABASE ID RELEASE 66%10145777 Retinoid metabolism and transport METABOLISM OF VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 66%10144806 Metabolism of vitamins and cofactors FIBRONECTIN MATRIX FORMATION%REACTOME%R-RNO-1566977.1 Fibronectin matrix formation RMTS METHYLATE HISTONE ARGININES%REACTOME%R-RNO-3214858.1 RMTs methylate histone arginines AMPK INHIBITS CHREBP TRANSCRIPTIONAL ACTIVATION ACTIVITY%REACTOME DATABASE ID RELEASE 66%10145123 AMPK inhibits chREBP transcriptional activation activity MAPK FAMILY SIGNALING CASCADES%REACTOME%R-RNO-5683057.1 MAPK family signaling cascades ACTIVATION OF NIMA KINASES NEK9, NEK6, NEK7%REACTOME%R-RNO-2980767.1 Activation of NIMA Kinases NEK9, NEK6, NEK7 CYSTEINE FORMATION FROM HOMOCYSTEINE%REACTOME%R-RNO-1614603.1 Cysteine formation from homocysteine NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION)%REACTOME%R-RNO-198725.1 Nuclear Events (kinase and transcription factor activation) PYRIMIDINE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 66%10144841 Pyrimidine biosynthesis ADAPTIVE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 66%10145356 Adaptive Immune System RAF-INDEPENDENT MAPK1 3 ACTIVATION%REACTOME DATABASE ID RELEASE 66%10144960 RAF-independent MAPK1 3 activation RNA POLYMERASE II TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 66%10144832 RNA Polymerase II Transcription Termination SYNTHESIS OF KETONE BODIES%REACTOME%R-RNO-77111.1 Synthesis of Ketone Bodies LACTOSE SYNTHESIS%REACTOME DATABASE ID RELEASE 66%10146097 Lactose synthesis DOWNSTREAM SIGNALING OF ACTIVATED FGFR4%REACTOME DATABASE ID RELEASE 66%10145261 Downstream signaling of activated FGFR4 VXPX CARGO-TARGETING TO CILIUM%REACTOME DATABASE ID RELEASE 66%10146083 VxPx cargo-targeting to cilium THE ROLE OF GTSE1 IN G2 M PROGRESSION AFTER G2 CHECKPOINT%REACTOME%R-RNO-8852276.1 The role of GTSE1 in G2 M progression after G2 checkpoint TWIK-RELATED SPINAL CORD K+ CHANNEL (TRESK)%REACTOME DATABASE ID RELEASE 66%10145846 TWIK-related spinal cord K+ channel (TRESK) NEUROTRANSMITTER RELEASE CYCLE%REACTOME%R-RNO-112310.1 Neurotransmitter release cycle FREE FATTY ACID RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145661 Free fatty acid receptors MAPK1 (ERK2) ACTIVATION%REACTOME DATABASE ID RELEASE 66%10144963 MAPK1 (ERK2) activation PROCESSING AND ACTIVATION OF SUMO%REACTOME%R-RNO-3215018.1 Processing and activation of SUMO RNA POLYMERASE II TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 66%10144905 RNA Polymerase II Transcription Initiation RUNX3 REGULATES WNT SIGNALING%REACTOME DATABASE ID RELEASE 66%10146277 RUNX3 regulates WNT signaling FORMATION OF EDITOSOMES BY ADAR PROTEINS%REACTOME%R-RNO-77042.1 Formation of editosomes by ADAR proteins ARACHIDONIC ACID METABOLISM%REACTOME%R-RNO-2142753.1 Arachidonic acid metabolism ION TRANSPORT BY P-TYPE ATPASES%REACTOME%R-RNO-936837.1 Ion transport by P-type ATPases PI-3K CASCADE:FGFR4%REACTOME%R-RNO-5654720.1 PI-3K cascade:FGFR4 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS%REACTOME DATABASE ID RELEASE 66%10144984 SLBP independent Processing of Histone Pre-mRNAs G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA%REACTOME%R-RNO-392451.1 G beta:gamma signalling through PI3Kgamma CLEC7A (DECTIN-1) SIGNALING%REACTOME%R-RNO-5607764.1 CLEC7A (Dectin-1) signaling CELL-EXTRACELLULAR MATRIX INTERACTIONS%REACTOME DATABASE ID RELEASE 66%10145642 Cell-extracellular matrix interactions SODIUM PROTON EXCHANGERS%REACTOME%R-RNO-425986.1 Sodium Proton exchangers INTERLEUKIN-7 SIGNALING%REACTOME%R-RNO-1266695.1 Interleukin-7 signaling ATTACHMENT OF GPI ANCHOR TO UPAR%REACTOME DATABASE ID RELEASE 66%10145107 Attachment of GPI anchor to uPAR ANTIGEN PROCESSING-CROSS PRESENTATION%REACTOME DATABASE ID RELEASE 66%10145813 Antigen processing-Cross presentation CALCITONIN-LIKE LIGAND RECEPTORS%REACTOME%R-RNO-419812.1 Calcitonin-like ligand receptors TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER%REACTOME%R-RNO-2173793.1 Transcriptional activity of SMAD2 SMAD3:SMAD4 heterotrimer P75NTR REGULATES AXONOGENESIS%REACTOME%R-RNO-193697.1 p75NTR regulates axonogenesis MET ACTIVATES PTPN11%REACTOME%R-RNO-8865999.1 MET activates PTPN11 RUNX1 AND FOXP3 CONTROL THE DEVELOPMENT OF REGULATORY T LYMPHOCYTES (TREGS)%REACTOME%R-RNO-8877330.1 RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) BILE ACID AND BILE SALT METABOLISM%REACTOME%R-RNO-194068.1 Bile acid and bile salt metabolism PREGNENOLONE BIOSYNTHESIS%REACTOME%R-RNO-196108.1 Pregnenolone biosynthesis CS DS DEGRADATION%REACTOME DATABASE ID RELEASE 66%10145885 CS DS degradation PI AND PC TRANSPORT BETWEEN ER AND GOLGI MEMBRANES%REACTOME%R-RNO-1483196.1 PI and PC transport between ER and Golgi membranes REELIN SIGNALLING PATHWAY%REACTOME DATABASE ID RELEASE 66%10146225 Reelin signalling pathway MRNA EDITING: A TO I CONVERSION%REACTOME%R-RNO-75064.1 mRNA Editing: A to I Conversion PHOSPHOLIPASE C-MEDIATED CASCADE; FGFR2%REACTOME DATABASE ID RELEASE 66%10146098 Phospholipase C-mediated cascade; FGFR2 MITOCHONDRIAL CALCIUM ION TRANSPORT%REACTOME%R-RNO-8949215.1 Mitochondrial calcium ion transport MITOCHONDRIAL ABC TRANSPORTERS%REACTOME%R-RNO-1369007.1 Mitochondrial ABC transporters TERMINATION OF TRANSLESION DNA SYNTHESIS%REACTOME DATABASE ID RELEASE 66%10146096 Termination of translesion DNA synthesis PEPTIDE HORMONE BIOSYNTHESIS%REACTOME%R-RNO-209952.1 Peptide hormone biosynthesis MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS%REACTOME%R-RNO-1362409.1 Mitochondrial iron-sulfur cluster biogenesis SEROTONIN NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 66%10145528 Serotonin Neurotransmitter Release Cycle LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATION FROM THE CENTROSOME%REACTOME%R-RNO-380284.1 Loss of proteins required for interphase microtubule organization from the centrosome LECTIN PATHWAY OF COMPLEMENT ACTIVATION%REACTOME%R-RNO-166662.1 Lectin pathway of complement activation FORMATION OF THE EARLY ELONGATION COMPLEX%REACTOME DATABASE ID RELEASE 66%10145012 Formation of the Early Elongation Complex PTK6 PROMOTES HIF1A STABILIZATION%REACTOME%R-RNO-8857538.1 PTK6 promotes HIF1A stabilization METABOLISM OF STEROID HORMONES%REACTOME DATABASE ID RELEASE 66%10145319 Metabolism of steroid hormones CHREBP ACTIVATES METABOLIC GENE EXPRESSION%REACTOME DATABASE ID RELEASE 66%10145124 ChREBP activates metabolic gene expression UREA CYCLE%REACTOME DATABASE ID RELEASE 66%10144786 Urea cycle MRNA EDITING%REACTOME%R-RNO-75072.1 mRNA Editing BETA OXIDATION OF LAUROYL-COA TO DECANOYL-COA-COA%REACTOME DATABASE ID RELEASE 66%10144931 Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA CASP8 ACTIVITY IS INHIBITED%REACTOME%R-RNO-5218900.1 CASP8 activity is inhibited PTK6 REGULATES CELL CYCLE%REACTOME DATABASE ID RELEASE 66%10146203 PTK6 Regulates Cell Cycle HYDROXYCARBOXYLIC ACID-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145664 Hydroxycarboxylic acid-binding receptors EFFECTS OF PIP2 HYDROLYSIS%REACTOME%R-RNO-114508.1 Effects of PIP2 hydrolysis UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A%REACTOME DATABASE ID RELEASE 66%10144752 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A SYNTHESIS OF PS%REACTOME%R-RNO-1483101.1 Synthesis of PS PHASE 4 - RESTING MEMBRANE POTENTIAL%REACTOME%R-RNO-5576886.1 Phase 4 - resting membrane potential NOTCH3 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME DATABASE ID RELEASE 66%10145951 NOTCH3 Activation and Transmission of Signal to the Nucleus BETA OXIDATION OF BUTANOYL-COA TO ACETYL-COA%REACTOME DATABASE ID RELEASE 66%10144935 Beta oxidation of butanoyl-CoA to acetyl-CoA UNWINDING OF DNA%REACTOME%R-RNO-176974.1 Unwinding of DNA PKB-MEDIATED EVENTS%REACTOME%R-RNO-109703.1 PKB-mediated events JOSEPHIN DOMAIN DUBS%REACTOME DATABASE ID RELEASE 66%10146138 Josephin domain DUBs HSP90 CHAPERONE CYCLE FOR SHRS%REACTOME DATABASE ID RELEASE 66%10146010 HSP90 chaperone cycle for SHRs NEUROFASCIN INTERACTIONS%REACTOME%R-RNO-447043.1 Neurofascin interactions COMPLEX I BIOGENESIS%REACTOME%R-RNO-6799198.1 Complex I biogenesis RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+%REACTOME%R-RNO-76005.1 Response to elevated platelet cytosolic Ca2+ GLUCONEOGENESIS%REACTOME%R-RNO-70263.1 Gluconeogenesis MAPK6 MAPK4 SIGNALING%REACTOME%R-RNO-5687128.1 MAPK6 MAPK4 signaling SIGNALING BY NUCLEAR RECEPTORS%REACTOME%R-RNO-9006931.1 Signaling by Nuclear Receptors ENOS ACTIVATION%REACTOME DATABASE ID RELEASE 66%10145394 eNOS activation GABA RECEPTOR ACTIVATION%REACTOME%R-RNO-977443.1 GABA receptor activation REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR%REACTOME DATABASE ID RELEASE 66%10145809 Regulation of gene expression by Hypoxia-inducible Factor STEROLS ARE 12-HYDROXYLATED BY CYP8B1%REACTOME%R-RNO-211994.1 Sterols are 12-hydroxylated by CYP8B1 WNT LIGAND BIOGENESIS AND TRAFFICKING%REACTOME%R-RNO-3238698.1 WNT ligand biogenesis and trafficking MET RECEPTOR ACTIVATION%REACTOME DATABASE ID RELEASE 66%10146172 MET Receptor Activation GPCR LIGAND BINDING%REACTOME DATABASE ID RELEASE 66%10145122 GPCR ligand binding TRIGLYCERIDE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 66%10144910 Triglyceride biosynthesis BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME%R-RNO-70895.1 Branched-chain amino acid catabolism NTRK2 ACTIVATES RAC1%REACTOME DATABASE ID RELEASE 66%10146322 NTRK2 activates RAC1 SIGNALING BY ERBB4%REACTOME%R-RNO-1236394.1 Signaling by ERBB4 DNA DAMAGE REVERSAL%REACTOME DATABASE ID RELEASE 66%10146231 DNA Damage Reversal DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX%REACTOME%R-RNO-3769402.1 Deactivation of the beta-catenin transactivating complex RECRUITMENT AND ATM-MEDIATED PHOSPHORYLATION OF REPAIR AND SIGNALING PROTEINS AT DNA DOUBLE STRAND BREAKS%REACTOME DATABASE ID RELEASE 66%10144760 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE%REACTOME%R-RNO-168179.1 Toll Like Receptor TLR1:TLR2 Cascade HEDGEHOG 'OFF' STATE%REACTOME%R-RNO-5610787.1 Hedgehog 'off' state APC-CDC20 MEDIATED DEGRADATION OF NEK2A%REACTOME DATABASE ID RELEASE 66%10145263 APC-Cdc20 mediated degradation of Nek2A NFG AND PRONGF BINDS TO P75NTR%REACTOME%R-RNO-205017.1 NFG and proNGF binds to p75NTR TRANSCRIPTIONAL ACTIVATION OF CELL CYCLE INHIBITOR P21%REACTOME DATABASE ID RELEASE 66%10146177 Transcriptional activation of cell cycle inhibitor p21 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS%REACTOME%R-RNO-416993.1 Trafficking of GluR2-containing AMPA receptors PROLINE CATABOLISM%REACTOME DATABASE ID RELEASE 66%10144794 Proline catabolism DEGRADATION OF GLI1 BY THE PROTEASOME%REACTOME DATABASE ID RELEASE 66%10146077 Degradation of GLI1 by the proteasome BETA OXIDATION OF DECANOYL-COA TO OCTANOYL-COA-COA%REACTOME%R-RNO-77346.1 Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA MMR%REACTOME%R-RNO-5358508.1 MMR POST-TRANSCRIPTIONAL SILENCING BY SMALL RNAS%REACTOME DATABASE ID RELEASE 66%10145622 Post-transcriptional silencing by small RNAs PI METABOLISM%REACTOME DATABASE ID RELEASE 66%10145378 PI Metabolism NEGATIVE REGULATION OF FGFR4 SIGNALING%REACTOME%R-RNO-5654733.1 Negative regulation of FGFR4 signaling NUCLEOBASE CATABOLISM%REACTOME%R-RNO-8956319.1 Nucleobase catabolism CROSS-PRESENTATION OF PARTICULATE EXOGENOUS ANTIGENS (PHAGOSOMES)%REACTOME%R-RNO-1236973.1 Cross-presentation of particulate exogenous antigens (phagosomes) MEIOSIS%REACTOME%R-RNO-1500620.1 Meiosis AKT-MEDIATED INACTIVATION OF FOXO1A%REACTOME DATABASE ID RELEASE 66%10145436 AKT-mediated inactivation of FOXO1A CREB PHOSPHORYLATION%REACTOME%R-RNO-199920.1 CREB phosphorylation RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN INTERLEUKIN SIGNALING%REACTOME DATABASE ID RELEASE 66%10146268 RUNX1 regulates transcription of genes involved in interleukin signaling SDK INTERACTIONS%REACTOME%R-RNO-373756.1 SDK interactions XENOBIOTICS%REACTOME DATABASE ID RELEASE 66%10144919 Xenobiotics SIGNALING PATHWAYS%REACTOME%R-RNO-162582.1 Signaling Pathways TRAF6 MEDIATED IRF7 ACTIVATION%REACTOME DATABASE ID RELEASE 66%10145758 TRAF6 mediated IRF7 activation NEUROTRANSMITTER RECEPTORS AND POSTSYNAPTIC SIGNAL TRANSMISSION%REACTOME%R-RNO-112314.1 Neurotransmitter receptors and postsynaptic signal transmission PLASMALOGEN BIOSYNTHESIS%REACTOME%R-RNO-75896.1 Plasmalogen biosynthesis TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING%REACTOME%R-RNO-975110.1 TRAF6 mediated IRF7 activation in TLR7 8 or 9 signaling ABACAVIR TRANSMEMBRANE TRANSPORT%REACTOME%R-RNO-2161517.1 Abacavir transmembrane transport RNA POLYMERASE I PROMOTER CLEARANCE%REACTOME%R-RNO-73854.1 RNA Polymerase I Promoter Clearance FCERI MEDIATED NF-KB ACTIVATION%REACTOME%R-RNO-2871837.1 FCERI mediated NF-kB activation THE AIM2 INFLAMMASOME%REACTOME%R-RNO-844615.1 The AIM2 inflammasome FORMATION OF RNA POL II ELONGATION COMPLEX%REACTOME%R-RNO-112382.1 Formation of RNA Pol II elongation complex NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%R-RNO-427413.1 NoRC negatively regulates rRNA expression FGFR3C LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 66%10145291 FGFR3c ligand binding and activation FATTY ACID METABOLISM%REACTOME%R-RNO-8978868.1 Fatty acid metabolism TNF RECEPTOR SUPERFAMILY (TNFSF) MEMBERS MEDIATING NON-CANONICAL NF-KB PATHWAY%REACTOME DATABASE ID RELEASE 66%10145372 TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway VEGFR2 MEDIATED VASCULAR PERMEABILITY%REACTOME%R-RNO-5218920.1 VEGFR2 mediated vascular permeability PI5P, PP2A AND IER3 REGULATE PI3K AKT SIGNALING%REACTOME%R-RNO-6811558.1 PI5P, PP2A and IER3 Regulate PI3K AKT Signaling FGFR1 LIGAND BINDING AND ACTIVATION%REACTOME%R-RNO-190242.1 FGFR1 ligand binding and activation SYNTHESIS OF PIPS AT THE ER MEMBRANE%REACTOME DATABASE ID RELEASE 66%10145900 Synthesis of PIPs at the ER membrane RHO GTPASES ACTIVATE IQGAPS%REACTOME DATABASE ID RELEASE 66%10146088 RHO GTPases activate IQGAPs RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 66%10145527 Recruitment of NuMA to mitotic centrosomes GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION%REACTOME%R-RNO-163841.1 Gamma carboxylation, hypusine formation and arylsulfatase activation GLYCINE DEGRADATION%REACTOME DATABASE ID RELEASE 66%10146148 Glycine degradation TANDEM PORE DOMAIN POTASSIUM CHANNELS%REACTOME DATABASE ID RELEASE 66%10145839 Tandem pore domain potassium channels DEGRADATION OF THE EXTRACELLULAR MATRIX%REACTOME%R-RNO-1474228.1 Degradation of the extracellular matrix ACYL CHAIN REMODELLING OF PG%REACTOME DATABASE ID RELEASE 66%10145863 Acyl chain remodelling of PG ACYL CHAIN REMODELING OF DAG AND TAG%REACTOME%R-RNO-1482883.1 Acyl chain remodeling of DAG and TAG NUCLEAR ENVELOPE BREAKDOWN%REACTOME DATABASE ID RELEASE 66%10145982 Nuclear Envelope Breakdown APC:CDC20 MEDIATED DEGRADATION OF CELL CYCLE PROTEINS PRIOR TO SATISFATION OF THE CELL CYCLE CHECKPOINT%REACTOME%R-RNO-179419.1 APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC%REACTOME DATABASE ID RELEASE 66%10145414 Antigen Presentation: Folding, assembly and peptide loading of class I MHC BLOCH PATHWAY%REACTOME%R-RNO-6807047.1 Bloch pathway RNA POLYMERASE I PROMOTER ESCAPE%REACTOME%R-RNO-73772.1 RNA Polymerase I Promoter Escape HDR THROUGH MMEJ (ALT-NHEJ)%REACTOME DATABASE ID RELEASE 66%10146137 HDR through MMEJ (alt-NHEJ) ALPHA-DEFENSINS%REACTOME%R-RNO-1462054.1 Alpha-defensins TOLL LIKE RECEPTOR 3 (TLR3) CASCADE%REACTOME DATABASE ID RELEASE 66%10145161 Toll Like Receptor 3 (TLR3) Cascade MET INTERACTS WITH TNS PROTEINS%REACTOME DATABASE ID RELEASE 66%10146251 MET interacts with TNS proteins INTERFERON GAMMA SIGNALING%REACTOME%R-RNO-877300.1 Interferon gamma signaling MAJOR PATHWAY OF RRNA PROCESSING IN THE NUCLEOLUS AND CYTOSOL%REACTOME%R-RNO-6791226.1 Major pathway of rRNA processing in the nucleolus and cytosol MET ACTIVATES STAT3%REACTOME%R-RNO-8875791.1 MET activates STAT3 ERYTHROCYTES TAKE UP CARBON DIOXIDE AND RELEASE OXYGEN%REACTOME DATABASE ID RELEASE 66%10145817 Erythrocytes take up carbon dioxide and release oxygen RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN BCR SIGNALING%REACTOME DATABASE ID RELEASE 66%10146269 RUNX1 regulates transcription of genes involved in BCR signaling G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%R-RNO-1296059.1 G protein gated Potassium channels CLEARANCE OF SERATONIN%REACTOME%R-RNO-380615.1 Clearance of seratonin MITOTIC PROMETAPHASE%REACTOME DATABASE ID RELEASE 66%10145506 Mitotic Prometaphase PLATELET SENSITIZATION BY LDL%REACTOME DATABASE ID RELEASE 66%10145634 Platelet sensitization by LDL REGULATION OF RUNX2 EXPRESSION AND ACTIVITY%REACTOME%R-RNO-8939902.1 Regulation of RUNX2 expression and activity RAB GERANYLGERANYLATION%REACTOME%R-RNO-8873719.1 RAB geranylgeranylation NEUROTRANSMITTER UPTAKE AND METABOLISM IN GLIAL CELLS%REACTOME%R-RNO-112313.1 Neurotransmitter uptake and metabolism In glial cells RAB GEFS EXCHANGE GTP FOR GDP ON RABS%REACTOME%R-RNO-8876198.1 RAB GEFs exchange GTP for GDP on RABs PRESYNAPTIC DEPOLARIZATION AND CALCIUM CHANNEL OPENING%REACTOME%R-RNO-112308.1 Presynaptic depolarization and calcium channel opening RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING%REACTOME DATABASE ID RELEASE 66%10144894 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening HISTIDINE CATABOLISM%REACTOME%R-RNO-70921.1 Histidine catabolism SIGNALING BY HIPPO%REACTOME DATABASE ID RELEASE 66%10145927 Signaling by Hippo RIBOSOMAL SCANNING AND START CODON RECOGNITION%REACTOME DATABASE ID RELEASE 66%10144836 Ribosomal scanning and start codon recognition PLATELET AGGREGATION (PLUG FORMATION)%REACTOME DATABASE ID RELEASE 66%10145477 Platelet Aggregation (Plug Formation) HEME BIOSYNTHESIS%REACTOME%R-RNO-189451.1 Heme biosynthesis NOD1 2 SIGNALING PATHWAY%REACTOME%R-RNO-168638.1 NOD1 2 Signaling Pathway INTERLEUKIN-4 AND INTERLEUKIN-13 SIGNALING%REACTOME%R-RNO-6785807.1 Interleukin-4 and Interleukin-13 signaling RELAXIN RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145665 Relaxin receptors ORGANIC CATION ANION ZWITTERION TRANSPORT%REACTOME%R-RNO-549132.1 Organic cation anion zwitterion transport CARNITINE SYNTHESIS%REACTOME DATABASE ID RELEASE 66%10144812 Carnitine synthesis CAM-PDE 1 ACTIVATION%REACTOME DATABASE ID RELEASE 66%10145008 Cam-PDE 1 activation HDR THROUGH SINGLE STRAND ANNEALING (SSA)%REACTOME DATABASE ID RELEASE 66%10144912 HDR through Single Strand Annealing (SSA) FASL CD95L SIGNALING%REACTOME%R-RNO-75157.1 FasL CD95L signaling SUMO IS PROTEOLYTICALLY PROCESSED%REACTOME%R-RNO-3065679.1 SUMO is proteolytically processed MAP2K AND MAPK ACTIVATION%REACTOME%R-RNO-5674135.1 MAP2K and MAPK activation ACTIVATION OF RAS IN B CELLS%REACTOME%R-RNO-1169092.1 Activation of RAS in B cells SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1%REACTOME DATABASE ID RELEASE 66%10145226 SCF-beta-TrCP mediated degradation of Emi1 ETHANOL OXIDATION%REACTOME DATABASE ID RELEASE 66%10144819 Ethanol oxidation RHO GTPASES REGULATE CFTR TRAFFICKING%REACTOME DATABASE ID RELEASE 66%10146090 RHO GTPases regulate CFTR trafficking FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF)%REACTOME DATABASE ID RELEASE 66%10146023 Formation of Senescence-Associated Heterochromatin Foci (SAHF) GOLGI-TO-ER RETROGRADE TRANSPORT%REACTOME%R-RNO-8856688.1 Golgi-to-ER retrograde transport REGULATION OF TP53 ACTIVITY THROUGH METHYLATION%REACTOME DATABASE ID RELEASE 66%10146002 Regulation of TP53 Activity through Methylation RESPIRATORY ELECTRON TRANSPORT%REACTOME%R-RNO-611105.1 Respiratory electron transport REVERSIBLE HYDRATION OF CARBON DIOXIDE%REACTOME%R-RNO-1475029.1 Reversible hydration of carbon dioxide SENSING OF DNA DOUBLE STRAND BREAKS%REACTOME%R-RNO-5693548.1 Sensing of DNA Double Strand Breaks NOSIP MEDIATED ENOS TRAFFICKING%REACTOME DATABASE ID RELEASE 66%10145408 NOSIP mediated eNOS trafficking BIOSYNTHESIS OF PROTECTIN AND RESOLVIN CONJUGATES IN TISSUE REGENERATION (PCTR AND RCTR)%REACTOME%R-RNO-9026766.1 Biosynthesis of protectin and resolvin conjugates in tissue regeneration (PCTR and RCTR) COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES%REACTOME%R-RNO-1650814.1 Collagen biosynthesis and modifying enzymes CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6%REACTOME%R-RNO-69017.1 CDK-mediated phosphorylation and removal of Cdc6 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24-HYDROXYCHOLESTEROL%REACTOME%R-RNO-193775.1 Synthesis of bile acids and bile salts via 24-hydroxycholesterol RUNX3 REGULATES CDKN1A TRANSCRIPTION%REACTOME%R-RNO-8941855.1 RUNX3 regulates CDKN1A transcription INTERLEUKIN-6 FAMILY SIGNALING%REACTOME%R-RNO-6783589.1 Interleukin-6 family signaling NA+ CL- DEPENDENT NEUROTRANSMITTER TRANSPORTERS%REACTOME%R-RNO-442660.1 Na+ Cl- dependent neurotransmitter transporters REGULATION OF MITOTIC CELL CYCLE%REACTOME%R-RNO-453276.1 Regulation of mitotic cell cycle ERKS ARE INACTIVATED%REACTOME DATABASE ID RELEASE 66%10145380 ERKs are inactivated PRE-NOTCH TRANSCRIPTION AND TRANSLATION%REACTOME DATABASE ID RELEASE 66%10146305 Pre-NOTCH Transcription and Translation VITAMIN B2 (RIBOFLAVIN) METABOLISM%REACTOME DATABASE ID RELEASE 66%10145350 Vitamin B2 (riboflavin) metabolism STABILIZATION OF P53%REACTOME%R-RNO-69541.1 Stabilization of p53 RESPONSE TO METAL IONS%REACTOME DATABASE ID RELEASE 66%10146118 Response to metal ions HYALURONAN METABOLISM%REACTOME%R-RNO-2142845.1 Hyaluronan metabolism ACTIVATION OF NA-PERMEABLE KAINATE RECEPTORS%REACTOME%R-RNO-451307.1 Activation of Na-permeable kainate receptors ELEVATION OF CYTOSOLIC CA2+ LEVELS%REACTOME%R-RNO-139853.1 Elevation of cytosolic Ca2+ levels TRANSLESION SYNTHESIS BY POLI%REACTOME DATABASE ID RELEASE 66%10146112 Translesion synthesis by POLI CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES)%REACTOME DATABASE ID RELEASE 66%10145812 Cross-presentation of soluble exogenous antigens (endosomes) GALACTOSE CATABOLISM%REACTOME DATABASE ID RELEASE 66%10144777 Galactose catabolism ERK MAPK TARGETS%REACTOME DATABASE ID RELEASE 66%10145363 ERK MAPK targets TRANSPORT OF GAMMA-CARBOXYLATED PROTEIN PRECURSORS FROM THE ENDOPLASMIC RETICULUM TO THE GOLGI APPARATUS%REACTOME%R-RNO-159763.1 Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus FORMATION OF TC-NER PRE-INCISION COMPLEX%REACTOME DATABASE ID RELEASE 66%10146151 Formation of TC-NER Pre-Incision Complex EICOSANOIDS%REACTOME%R-RNO-211979.1 Eicosanoids MRNA CAPPING%REACTOME DATABASE ID RELEASE 66%10144929 mRNA Capping MITOTIC SPINDLE CHECKPOINT%REACTOME DATABASE ID RELEASE 66%10145064 Mitotic Spindle Checkpoint SYNTHESIS OF HEPOXILINS (HX) AND TRIOXILINS (TRX)%REACTOME%R-RNO-2142696.1 Synthesis of Hepoxilins (HX) and Trioxilins (TrX) P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME%R-RNO-69613.1 p53-Independent G1 S DNA damage checkpoint SHC1 EVENTS IN ERBB2 SIGNALING%REACTOME DATABASE ID RELEASE 66%10145824 SHC1 events in ERBB2 signaling ACTIVATION OF MATRIX METALLOPROTEINASES%REACTOME%R-RNO-1592389.1 Activation of Matrix Metalloproteinases TANDEM OF PORE DOMAIN IN A WEAK INWARDLY RECTIFYING K+ CHANNELS (TWIK)%REACTOME DATABASE ID RELEASE 66%10145844 Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK) FRUCTOSE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 66%10146095 Fructose biosynthesis TRANSLOCATION OF ZAP-70 TO IMMUNOLOGICAL SYNAPSE%REACTOME DATABASE ID RELEASE 66%10145399 Translocation of ZAP-70 to Immunological synapse BIOSYNTHESIS OF DPAN-3-DERIVED PROTECTINS AND RESOLVINS%REACTOME%R-RNO-9026286.1 Biosynthesis of DPAn-3-derived protectins and resolvins REGULATION OF APOPTOSIS%REACTOME DATABASE ID RELEASE 66%10146243 Regulation of Apoptosis SYNTHESIS OF (16-20)-HYDROXYEICOSATETRAENOIC ACIDS (HETE)%REACTOME%R-RNO-2142816.1 Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) KERATAN SULFATE KERATIN METABOLISM%REACTOME DATABASE ID RELEASE 66%10145729 Keratan sulfate keratin metabolism CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A%REACTOME DATABASE ID RELEASE 66%10145216 Cdc20:Phospho-APC C mediated degradation of Cyclin A LDL CLEARANCE%REACTOME%R-RNO-8964038.1 LDL clearance TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX%REACTOME%R-RNO-445989.1 TAK1 activates NFkB by phosphorylation and activation of IKKs complex CHEMOKINE RECEPTORS BIND CHEMOKINES%REACTOME%R-RNO-380108.1 Chemokine receptors bind chemokines AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL%REACTOME%R-RNO-198323.1 AKT phosphorylates targets in the cytosol PROCESSING OF DNA DOUBLE-STRAND BREAK ENDS%REACTOME DATABASE ID RELEASE 66%10146130 Processing of DNA double-strand break ends CARGO TRAFFICKING TO THE PERICILIARY MEMBRANE%REACTOME DATABASE ID RELEASE 66%10146079 Cargo trafficking to the periciliary membrane GLYCEROPHOSPHOLIPID BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 66%10144908 Glycerophospholipid biosynthesis NEUROPHILIN INTERACTIONS WITH VEGF AND VEGFR%REACTOME%R-RNO-194306.1 Neurophilin interactions with VEGF and VEGFR DNA REPLICATION PRE-INITIATION%REACTOME DATABASE ID RELEASE 66%10144714 DNA Replication Pre-Initiation PRESYNAPTIC FUNCTION OF KAINATE RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145706 Presynaptic function of Kainate receptors NADPH REGENERATION%REACTOME DATABASE ID RELEASE 66%10145547 NADPH regeneration KERATAN SULFATE DEGRADATION%REACTOME%R-RNO-2022857.1 Keratan sulfate degradation BIOSYNTHESIS OF D-SERIES RESOLVINS%REACTOME DATABASE ID RELEASE 66%10146303 Biosynthesis of D-series resolvins AMPLIFICATION OF SIGNAL FROM THE KINETOCHORES%REACTOME%R-RNO-141424.1 Amplification of signal from the kinetochores REGULATION OF INSULIN SECRETION%REACTOME DATABASE ID RELEASE 66%10145114 Regulation of insulin secretion INTERLEUKIN-23 SIGNALING%REACTOME%R-RNO-9020933.1 Interleukin-23 signaling CALCINEURIN ACTIVATES NFAT%REACTOME DATABASE ID RELEASE 66%10145926 Calcineurin activates NFAT RNA POLYMERASE I TRANSCRIPTION%REACTOME%R-RNO-73864.1 RNA Polymerase I Transcription SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS%REACTOME%R-RNO-75876.1 Synthesis of very long-chain fatty acyl-CoAs REGULATION OF COMPLEMENT CASCADE%REACTOME%R-RNO-977606.1 Regulation of Complement cascade MTORC1-MEDIATED SIGNALLING%REACTOME%R-RNO-166208.1 mTORC1-mediated signalling METABOLISM OF POLYAMINES%REACTOME%R-RNO-351202.1 Metabolism of polyamines G2 M CHECKPOINTS%REACTOME DATABASE ID RELEASE 66%10144759 G2 M Checkpoints ORGANIC CATION TRANSPORT%REACTOME%R-RNO-549127.1 Organic cation transport TRANSCRIPTIONAL ACTIVATION OF P53 RESPONSIVE GENES%REACTOME DATABASE ID RELEASE 66%10146178 Transcriptional activation of p53 responsive genes CREATION OF C4 AND C2 ACTIVATORS%REACTOME DATABASE ID RELEASE 66%10145209 Creation of C4 and C2 activators GLUCOSE METABOLISM%REACTOME%R-RNO-70326.1 Glucose metabolism INTERLEUKIN-27 SIGNALING%REACTOME%R-RNO-9020956.1 Interleukin-27 signaling TRANSCRIPTIONAL REGULATION BY THE AP-2 (TFAP2) FAMILY OF TRANSCRIPTION FACTORS%REACTOME%R-RNO-8864260.1 Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION)%REACTOME%R-RNO-2173791.1 TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) NEGATIVE REGULATION OF TCF-DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS%REACTOME DATABASE ID RELEASE 66%10146021 Negative regulation of TCF-dependent signaling by WNT ligand antagonists BETA OXIDATION OF OCTANOYL-COA TO HEXANOYL-COA%REACTOME DATABASE ID RELEASE 66%10144937 Beta oxidation of octanoyl-CoA to hexanoyl-CoA RAB REGULATION OF TRAFFICKING%REACTOME DATABASE ID RELEASE 66%10146223 Rab regulation of trafficking NEUREXINS AND NEUROLIGINS%REACTOME%R-RNO-6794361.1 Neurexins and neuroligins FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS%REACTOME%R-RNO-2029480.1 Fcgamma receptor (FCGR) dependent phagocytosis ENDOGENOUS STEROLS%REACTOME DATABASE ID RELEASE 66%10145314 Endogenous sterols SPRY REGULATION OF FGF SIGNALING%REACTOME DATABASE ID RELEASE 66%10145760 Spry regulation of FGF signaling ER-PHAGOSOME PATHWAY%REACTOME DATABASE ID RELEASE 66%10145816 ER-Phagosome pathway OTHER SEMAPHORIN INTERACTIONS%REACTOME%R-RNO-416700.1 Other semaphorin interactions SIGNALING BY BMP%REACTOME DATABASE ID RELEASE 66%10145385 Signaling by BMP NEGATIVE REGULATION OF FGFR2 SIGNALING%REACTOME DATABASE ID RELEASE 66%10145762 Negative regulation of FGFR2 signaling REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF)%REACTOME DATABASE ID RELEASE 66%10145896 Regulation of cholesterol biosynthesis by SREBP (SREBF) APOPTOSIS%REACTOME DATABASE ID RELEASE 66%10144862 Apoptosis DERMATAN SULFATE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 66%10145924 Dermatan sulfate biosynthesis CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION%REACTOME DATABASE ID RELEASE 66%10144735 Cyclin E associated events during G1 S transition BIOGENIC AMINES ARE OXIDATIVELY DEAMINATED TO ALDEHYDES BY MAOA AND MAOB%REACTOME DATABASE ID RELEASE 66%10145055 Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB TNF SIGNALING%REACTOME%R-RNO-75893.1 TNF signaling DIGESTION OF DIETARY CARBOHYDRATE%REACTOME%R-RNO-189085.1 Digestion of dietary carbohydrate PLATELET DEGRANULATION%REACTOME DATABASE ID RELEASE 66%10145469 Platelet degranulation PROGRAMMED CELL DEATH%REACTOME%R-RNO-5357801.1 Programmed Cell Death SIGNALING BY NOTCH2%REACTOME DATABASE ID RELEASE 66%10145921 Signaling by NOTCH2 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS)%REACTOME DATABASE ID RELEASE 66%10145487 Class A 1 (Rhodopsin-like receptors) TELOMERE C-STRAND SYNTHESIS INITIATION%REACTOME DATABASE ID RELEASE 66%10145233 Telomere C-strand synthesis initiation DCC MEDIATED ATTRACTIVE SIGNALING%REACTOME%R-RNO-418885.1 DCC mediated attractive signaling THE FATTY ACID CYCLING MODEL%REACTOME DATABASE ID RELEASE 66%10145135 The fatty acid cycling model SYNTHESIS OF UDP-N-ACETYL-GLUCOSAMINE%REACTOME%R-RNO-446210.1 Synthesis of UDP-N-acetyl-glucosamine HYALURONAN BIOSYNTHESIS AND EXPORT%REACTOME%R-RNO-2142850.1 Hyaluronan biosynthesis and export SMOOTH MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 66%10145669 Smooth Muscle Contraction DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX%REACTOME%R-RNO-195253.1 Degradation of beta-catenin by the destruction complex POLO-LIKE KINASE MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 66%10145073 Polo-like kinase mediated events SYNTHESIS OF 12-EICOSATETRAENOIC ACID DERIVATIVES%REACTOME DATABASE ID RELEASE 66%10145948 Synthesis of 12-eicosatetraenoic acid derivatives BETAKLOTHO-MEDIATED LIGAND BINDING%REACTOME%R-RNO-1307965.1 betaKlotho-mediated ligand binding CYCLIN D ASSOCIATED EVENTS IN G1%REACTOME DATABASE ID RELEASE 66%10144736 Cyclin D associated events in G1 DNA DOUBLE-STRAND BREAK REPAIR%REACTOME DATABASE ID RELEASE 66%10144762 DNA Double-Strand Break Repair NICOTINATE METABOLISM%REACTOME%R-RNO-196807.1 Nicotinate metabolism ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS%REACTOME DATABASE ID RELEASE 66%10145788 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION)%REACTOME%R-RNO-70614.1 Amino acid synthesis and interconversion (transamination) TRANSPORT OF ORGANIC ANIONS%REACTOME DATABASE ID RELEASE 66%10145337 Transport of organic anions NIK-->NONCANONICAL NF-KB SIGNALING%REACTOME DATABASE ID RELEASE 66%10146074 NIK-->noncanonical NF-kB signaling HISTAMINE RECEPTORS%REACTOME%R-RNO-390650.1 Histamine receptors SHC-MEDIATED CASCADE:FGFR4%REACTOME%R-RNO-5654719.1 SHC-mediated cascade:FGFR4 APEX1-INDEPENDENT RESOLUTION OF AP SITES VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 66%10146092 APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway UNFOLDED PROTEIN RESPONSE (UPR)%REACTOME DATABASE ID RELEASE 66%10145530 Unfolded Protein Response (UPR) STIMULI-SENSING CHANNELS%REACTOME%R-RNO-2672351.1 Stimuli-sensing channels GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS)%REACTOME DATABASE ID RELEASE 66%10144780 Glycogen breakdown (glycogenolysis) B CELL ACTIVATION%REACTOME DATABASE ID RELEASE 66%10145789 B Cell Activation PTK6 REGULATES RHO GTPASES, RAS GTPASE AND MAP KINASES%REACTOME DATABASE ID RELEASE 66%10146205 PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases EPH-EPHRIN SIGNALING%REACTOME DATABASE ID RELEASE 66%10146025 EPH-Ephrin signaling TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN CYTOCHROME C RELEASE%REACTOME%R-RNO-6803204.1 TP53 Regulates Transcription of Genes Involved in Cytochrome C Release POLYMERASE SWITCHING%REACTOME DATABASE ID RELEASE 66%10144729 Polymerase switching PERK REGULATES GENE EXPRESSION%REACTOME DATABASE ID RELEASE 66%10145531 PERK regulates gene expression REGULATION OF RUNX3 EXPRESSION AND ACTIVITY%REACTOME%R-RNO-8941858.1 Regulation of RUNX3 expression and activity LIGAND-RECEPTOR INTERACTIONS%REACTOME DATABASE ID RELEASE 66%10145666 Ligand-receptor interactions PLATELET HOMEOSTASIS%REACTOME DATABASE ID RELEASE 66%10145040 Platelet homeostasis CLASSICAL ANTIBODY-MEDIATED COMPLEMENT ACTIVATION%REACTOME%R-RNO-173623.1 Classical antibody-mediated complement activation ZINC TRANSPORTERS%REACTOME DATABASE ID RELEASE 66%10145654 Zinc transporters TRANSCRIPTIONAL REGULATION BY SMALL RNAS%REACTOME DATABASE ID RELEASE 66%10146071 Transcriptional regulation by small RNAs INTERFERON SIGNALING%REACTOME%R-RNO-913531.1 Interferon Signaling IRS ACTIVATION%REACTOME DATABASE ID RELEASE 66%10144874 IRS activation BUTYROPHILIN (BTN) FAMILY INTERACTIONS%REACTOME%R-RNO-8851680.1 Butyrophilin (BTN) family interactions NUCLEOTIDE SALVAGE%REACTOME%R-RNO-8956321.1 Nucleotide salvage COENZYME A BIOSYNTHESIS%REACTOME%R-RNO-196783.1 Coenzyme A biosynthesis TRANSLESION SYNTHESIS BY POLK%REACTOME DATABASE ID RELEASE 66%10146111 Translesion synthesis by POLK KERATINIZATION%REACTOME%R-RNO-6805567.1 Keratinization MRNA 3'-END PROCESSING%REACTOME DATABASE ID RELEASE 66%10144830 mRNA 3'-end processing MITOCHONDRIAL BIOGENESIS%REACTOME DATABASE ID RELEASE 66%10145879 Mitochondrial biogenesis RIP-MEDIATED NFKB ACTIVATION VIA ZBP1%REACTOME%R-RNO-1810476.1 RIP-mediated NFkB activation via ZBP1 TWIK-RELEATED ACID-SENSITIVE K+ CHANNEL (TASK)%REACTOME DATABASE ID RELEASE 66%10145845 TWIK-releated acid-sensitive K+ channel (TASK) FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX%REACTOME DATABASE ID RELEASE 66%10144838 Formation of the ternary complex, and subsequently, the 43S complex GLYCOGEN SYNTHESIS%REACTOME%R-RNO-3322077.1 Glycogen synthesis IRAK1 RECRUITS IKK COMPLEX%REACTOME DATABASE ID RELEASE 66%10145768 IRAK1 recruits IKK complex G2 M DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 66%10144758 G2 M DNA damage checkpoint SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%R-RNO-427359.1 SIRT1 negatively regulates rRNA expression CONDENSATION OF PROMETAPHASE CHROMOSOMES%REACTOME DATABASE ID RELEASE 66%10145973 Condensation of Prometaphase Chromosomes NEGATIVE REGULATION OF FGFR3 SIGNALING%REACTOME%R-RNO-5654732.1 Negative regulation of FGFR3 signaling NEDDYLATION%REACTOME DATABASE ID RELEASE 66%10146142 Neddylation ORGANELLE BIOGENESIS AND MAINTENANCE%REACTOME DATABASE ID RELEASE 66%10145880 Organelle biogenesis and maintenance P53-INDEPENDENT DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 66%10144753 p53-Independent DNA Damage Response TFAP2 (AP-2) FAMILY REGULATES TRANSCRIPTION OF CELL CYCLE FACTORS%REACTOME%R-RNO-8866911.1 TFAP2 (AP-2) family regulates transcription of cell cycle factors REGULATION OF IFNG SIGNALING%REACTOME DATABASE ID RELEASE 66%10145739 Regulation of IFNG signaling FGFR1C LIGAND BINDING AND ACTIVATION%REACTOME%R-RNO-190373.1 FGFR1c ligand binding and activation REGULATION OF RAS BY GAPS%REACTOME%R-RNO-5658442.1 Regulation of RAS by GAPs RETROGRADE TRANSPORT AT THE TRANS-GOLGI-NETWORK%REACTOME%R-RNO-6811440.1 Retrograde transport at the Trans-Golgi-Network TRANSLOCATION OF SLC2A4 (GLUT4) TO THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 66%10145854 Translocation of SLC2A4 (GLUT4) to the plasma membrane ACTIVATION OF NMDA RECEPTORS AND POSTSYNAPTIC EVENTS%REACTOME%R-RNO-442755.1 Activation of NMDA receptors and postsynaptic events INTERACTION WITH CUMULUS CELLS%REACTOME DATABASE ID RELEASE 66%10145974 Interaction With Cumulus Cells INTERLEUKIN-9 SIGNALING%REACTOME%R-RNO-8985947.1 Interleukin-9 signaling SIGNALING BY NOTCH%REACTOME DATABASE ID RELEASE 66%10145914 Signaling by NOTCH SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE%REACTOME DATABASE ID RELEASE 66%10144727 Switching of origins to a post-replicative state SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA-HYDROXYCHOLESTEROL%REACTOME DATABASE ID RELEASE 66%10145313 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 66%10145498 Semaphorin interactions CREATINE METABOLISM%REACTOME DATABASE ID RELEASE 66%10144813 Creatine metabolism PHOSPHORYLATION OF PROTEINS INVOLVED IN G1 S TRANSITION BY ACTIVE CYCLIN E:CDK2 COMPLEXES%REACTOME DATABASE ID RELEASE 66%10145275 Phosphorylation of proteins involved in G1 S transition by active Cyclin E:Cdk2 complexes INTRINSIC PATHWAY OF FIBRIN CLOT FORMATION%REACTOME DATABASE ID RELEASE 66%10145080 Intrinsic Pathway of Fibrin Clot Formation RUNX1 INTERACTS WITH CO-FACTORS WHOSE PRECISE EFFECT ON RUNX1 TARGETS IS NOT KNOWN%REACTOME%R-RNO-8939243.1 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known SUMO IS TRANSFERRED FROM E1 TO E2 (UBE2I, UBC9)%REACTOME DATABASE ID RELEASE 66%10145988 SUMO is transferred from E1 to E2 (UBE2I, UBC9) VITAMIN D (CALCIFEROL) METABOLISM%REACTOME%R-RNO-196791.1 Vitamin D (calciferol) metabolism ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM%REACTOME%R-RNO-2046104.1 alpha-linolenic (omega3) and linoleic (omega6) acid metabolism KERATAN SULFATE BIOSYNTHESIS%REACTOME%R-RNO-2022854.1 Keratan sulfate biosynthesis ACTIVATION OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 66%10144723 Activation of the pre-replicative complex HCN CHANNELS%REACTOME%R-RNO-1296061.1 HCN channels SUMOYLATION OF DNA REPLICATION PROTEINS%REACTOME%R-RNO-4615885.1 SUMOylation of DNA replication proteins HEDGEHOG 'ON' STATE%REACTOME%R-RNO-5632684.1 Hedgehog 'on' state FRS2-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 66%10145200 Frs2-mediated activation G BETA:GAMMA SIGNALLING THROUGH PLC BETA%REACTOME DATABASE ID RELEASE 66%10145577 G beta:gamma signalling through PLC beta INHIBITION OF TSC COMPLEX FORMATION BY PKB%REACTOME%R-RNO-165181.1 Inhibition of TSC complex formation by PKB NEGATIVE REGULATION OF FGFR1 SIGNALING%REACTOME%R-RNO-5654726.1 Negative regulation of FGFR1 signaling PLASMA LIPOPROTEIN REMODELING%REACTOME%R-RNO-8963899.1 Plasma lipoprotein remodeling AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE%REACTOME%R-RNO-352230.1 Amino acid transport across the plasma membrane APOPTOSIS INDUCED DNA FRAGMENTATION%REACTOME DATABASE ID RELEASE 66%10145440 Apoptosis induced DNA fragmentation NF-KB IS ACTIVATED AND SIGNALS SURVIVAL%REACTOME%R-RNO-209560.1 NF-kB is activated and signals survival CELLULAR RESPONSE TO HEAT STRESS%REACTOME%R-RNO-3371556.1 Cellular response to heat stress TRANSPORT OF NUCLEOTIDE SUGARS%REACTOME%R-RNO-727802.1 Transport of nucleotide sugars SEPARATION OF SISTER CHROMATIDS%REACTOME DATABASE ID RELEASE 66%10145223 Separation of Sister Chromatids GAMMA-CARBOXYLATION OF PROTEIN PRECURSORS%REACTOME%R-RNO-159740.1 Gamma-carboxylation of protein precursors REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND%REACTOME DATABASE ID RELEASE 66%10145237 Removal of the Flap Intermediate from the C-strand SMAC-MEDIATED APOPTOTIC RESPONSE%REACTOME DATABASE ID RELEASE 66%10145021 SMAC-mediated apoptotic response PI-3K CASCADE:FGFR1%REACTOME%R-RNO-5654689.1 PI-3K cascade:FGFR1 METABOLISM OF COFACTORS%REACTOME DATABASE ID RELEASE 66%10145548 Metabolism of cofactors EUKARYOTIC TRANSLATION ELONGATION%REACTOME%R-RNO-156842.1 Eukaryotic Translation Elongation TELOMERE EXTENSION BY TELOMERASE%REACTOME DATABASE ID RELEASE 66%10145110 Telomere Extension By Telomerase SIGNALLING TO ERKS%REACTOME DATABASE ID RELEASE 66%10145182 Signalling to ERKs LAGGING STRAND SYNTHESIS%REACTOME%R-RNO-69186.1 Lagging Strand Synthesis POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS%REACTOME DATABASE ID RELEASE 66%10145102 Post-translational modification: synthesis of GPI-anchored proteins DIGESTION OF DIETARY LIPID%REACTOME%R-RNO-192456.1 Digestion of dietary lipid WNT5A-DEPENDENT INTERNALIZATION OF FZD4%REACTOME DATABASE ID RELEASE 66%10146042 WNT5A-dependent internalization of FZD4 COMMON PATHWAY OF FIBRIN CLOT FORMATION%REACTOME%R-RNO-140875.1 Common Pathway of Fibrin Clot Formation ACYL CHAIN REMODELLING OF PS%REACTOME DATABASE ID RELEASE 66%10145868 Acyl chain remodelling of PS ASSEMBLY OF THE ORC COMPLEX AT THE ORIGIN OF REPLICATION%REACTOME DATABASE ID RELEASE 66%10144712 Assembly of the ORC complex at the origin of replication HSF1 ACTIVATION%REACTOME%R-RNO-3371511.1 HSF1 activation NON-CODING RNA METABOLISM%REACTOME%R-RNO-194441.1 Non-coding RNA Metabolism REGULATION OF TP53 ACTIVITY THROUGH PHOSPHORYLATION%REACTOME DATABASE ID RELEASE 66%10144756 Regulation of TP53 Activity through Phosphorylation MITOCHONDRIAL TRANSLATION TERMINATION%REACTOME DATABASE ID RELEASE 66%10146065 Mitochondrial translation termination CONJUGATION OF CARBOXYLIC ACIDS%REACTOME DATABASE ID RELEASE 66%10145090 Conjugation of carboxylic acids OPSINS%REACTOME%R-RNO-419771.1 Opsins TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES%REACTOME DATABASE ID RELEASE 66%10144951 Transport of vitamins, nucleosides, and related molecules EICOSANOID LIGAND-BINDING RECEPTORS%REACTOME%R-RNO-391903.1 Eicosanoid ligand-binding receptors FRUCTOSE METABOLISM%REACTOME%R-RNO-5652084.1 Fructose metabolism B-WICH COMPLEX POSITIVELY REGULATES RRNA EXPRESSION%REACTOME DATABASE ID RELEASE 66%10146051 B-WICH complex positively regulates rRNA expression PCNA-DEPENDENT LONG PATCH BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 66%10144982 PCNA-Dependent Long Patch Base Excision Repair TNFS BIND THEIR PHYSIOLOGICAL RECEPTORS%REACTOME DATABASE ID RELEASE 66%10146122 TNFs bind their physiological receptors INTERLEUKIN-37 SIGNALING%REACTOME DATABASE ID RELEASE 66%10146292 Interleukin-37 signaling RETROGRADE NEUROTROPHIN SIGNALLING%REACTOME%R-RNO-177504.1 Retrograde neurotrophin signalling PRPP BIOSYNTHESIS%REACTOME%R-RNO-73843.1 PRPP biosynthesis RHO GTPASES ACTIVATE KTN1%REACTOME%R-RNO-5625970.1 RHO GTPases activate KTN1 PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS%REACTOME%R-RNO-202427.1 Phosphorylation of CD3 and TCR zeta chains ACTIVATION OF GABAB RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145188 Activation of GABAB receptors CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS%REACTOME%R-RNO-442742.1 CREB phosphorylation through the activation of Ras ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 66%10145158 Activation of the AP-1 family of transcription factors SYNTHESIS OF DOLICHYL-PHOSPHATE-GLUCOSE%REACTOME DATABASE ID RELEASE 66%10145673 Synthesis of dolichyl-phosphate-glucose PTK6 REGULATES RTKS AND THEIR EFFECTORS AKT1 AND DOK1%REACTOME DATABASE ID RELEASE 66%10146206 PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 COHESIN LOADING ONTO CHROMATIN%REACTOME%R-RNO-2470946.1 Cohesin Loading onto Chromatin SEMA3A PAK DEPENDENT AXON REPULSION%REACTOME DATABASE ID RELEASE 66%10145582 Sema3A PAK dependent Axon repulsion ATTENUATION PHASE%REACTOME DATABASE ID RELEASE 66%10146014 Attenuation phase RNA POLYMERASE II TRANSCRIPTION%REACTOME DATABASE ID RELEASE 66%10144750 RNA Polymerase II Transcription ROLE OF ABL IN ROBO-SLIT SIGNALING%REACTOME%R-RNO-428890.1 Role of ABL in ROBO-SLIT signaling SIGNALING BY FGFR3%REACTOME DATABASE ID RELEASE 66%10145259 Signaling by FGFR3 COLLAGEN FORMATION%REACTOME%R-RNO-1474290.1 Collagen formation DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION%REACTOME%R-RNO-3134963.1 DEx H-box helicases activate type I IFN and inflammatory cytokines production SUMOYLATION OF SUMOYLATION PROTEINS%REACTOME DATABASE ID RELEASE 66%10146029 SUMOylation of SUMOylation proteins REGULATED NECROSIS%REACTOME%R-RNO-5218859.1 Regulated Necrosis SYNTHESIS OF 15-EICOSATETRAENOIC ACID DERIVATIVES%REACTOME DATABASE ID RELEASE 66%10145944 Synthesis of 15-eicosatetraenoic acid derivatives EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA%REACTOME%R-RNO-212718.1 EGFR interacts with phospholipase C-gamma PHOSPHORYLATION OF EMI1%REACTOME DATABASE ID RELEASE 66%10145225 Phosphorylation of Emi1 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY%REACTOME%R-RNO-3301854.1 Nuclear Pore Complex (NPC) Disassembly REPRESSION OF WNT TARGET GENES%REACTOME DATABASE ID RELEASE 66%10146038 Repression of WNT target genes APOPTOTIC EXECUTION PHASE%REACTOME DATABASE ID RELEASE 66%10145388 Apoptotic execution phase RUNX3 REGULATES NOTCH SIGNALING%REACTOME%R-RNO-8941856.1 RUNX3 regulates NOTCH signaling VEGFR2 MEDIATED CELL PROLIFERATION%REACTOME DATABASE ID RELEASE 66%10146032 VEGFR2 mediated cell proliferation NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145596 Nucleotide-like (purinergic) receptors SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 27-HYDROXYCHOLESTEROL%REACTOME%R-RNO-193807.1 Synthesis of bile acids and bile salts via 27-hydroxycholesterol INTEGRIN SIGNALING%REACTOME DATABASE ID RELEASE 66%10145478 Integrin signaling G ALPHA (I) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 66%10144868 G alpha (i) signalling events TRANSMISSION ACROSS CHEMICAL SYNAPSES%REACTOME%R-RNO-112315.1 Transmission across Chemical Synapses FGFR2 LIGAND BINDING AND ACTIVATION%REACTOME%R-RNO-190241.1 FGFR2 ligand binding and activation SIGNALING BY NON-RECEPTOR TYROSINE KINASES%REACTOME DATABASE ID RELEASE 66%10146199 Signaling by Non-Receptor Tyrosine Kinases CARDIAC CONDUCTION%REACTOME%R-RNO-5576891.1 Cardiac conduction TBC RABGAPS%REACTOME DATABASE ID RELEASE 66%10146222 TBC RABGAPs FBXL7 DOWN-REGULATES AURKA DURING MITOTIC ENTRY AND IN EARLY MITOSIS%REACTOME%R-RNO-8854050.1 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis COPI-INDEPENDENT GOLGI-TO-ER RETROGRADE TRAFFIC%REACTOME%R-RNO-6811436.1 COPI-independent Golgi-to-ER retrograde traffic TANDEM PORE DOMAIN HALOTHANE-INHIBITED K+ CHANNEL (THIK)%REACTOME DATABASE ID RELEASE 66%10145843 Tandem pore domain halothane-inhibited K+ channel (THIK) PYROPHOSPHATE HYDROLYSIS%REACTOME%R-RNO-71737.1 Pyrophosphate hydrolysis MITOPHAGY%REACTOME DATABASE ID RELEASE 66%10146046 Mitophagy LYSOSOMAL OLIGOSACCHARIDE CATABOLISM%REACTOME DATABASE ID RELEASE 66%10146170 Lysosomal oligosaccharide catabolism POTASSIUM CHANNELS%REACTOME%R-RNO-1296071.1 Potassium Channels PI3K CASCADE%REACTOME DATABASE ID RELEASE 66%10144954 PI3K Cascade BREAKDOWN OF THE NUCLEAR LAMINA%REACTOME%R-RNO-352238.1 Breakdown of the nuclear lamina ACTIVATION, TRANSLOCATION AND OLIGOMERIZATION OF BAX%REACTOME DATABASE ID RELEASE 66%10145017 Activation, translocation and oligomerization of BAX ENDOSOMAL VACUOLAR PATHWAY%REACTOME%R-RNO-1236977.1 Endosomal Vacuolar pathway ABACAVIR METABOLISM%REACTOME%R-RNO-2161541.1 Abacavir metabolism PROTEIN FOLDING%REACTOME%R-RNO-391251.1 Protein folding ACTIVATION OF BIM AND TRANSLOCATION TO MITOCHONDRIA%REACTOME DATABASE ID RELEASE 66%10145048 Activation of BIM and translocation to mitochondria SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION%REACTOME%R-RNO-399955.1 SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion SIGNALING BY NTRKS%REACTOME%R-RNO-166520.1 Signaling by NTRKs HUR (ELAVL1) BINDS AND STABILIZES MRNA%REACTOME DATABASE ID RELEASE 66%10145693 HuR (ELAVL1) binds and stabilizes mRNA INTESTINAL LIPID ABSORPTION%REACTOME DATABASE ID RELEASE 66%10145460 Intestinal lipid absorption RNA POLYMERASE I PROMOTER OPENING%REACTOME DATABASE ID RELEASE 66%10144847 RNA Polymerase I Promoter Opening INTEGRIN CELL SURFACE INTERACTIONS%REACTOME%R-RNO-216083.1 Integrin cell surface interactions TNFR2 NON-CANONICAL NF-KB PATHWAY%REACTOME DATABASE ID RELEASE 66%10145373 TNFR2 non-canonical NF-kB pathway N-GLYCAN TRIMMING AND ELONGATION IN THE CIS-GOLGI%REACTOME DATABASE ID RELEASE 66%10145771 N-glycan trimming and elongation in the cis-Golgi FRS-MEDIATED FGFR4 SIGNALING%REACTOME DATABASE ID RELEASE 66%10146106 FRS-mediated FGFR4 signaling G-PROTEIN ACTIVATION%REACTOME%R-RNO-202040.1 G-protein activation OXIDATIVE STRESS INDUCED SENESCENCE%REACTOME DATABASE ID RELEASE 66%10145165 Oxidative Stress Induced Senescence TACHYKININ RECEPTORS BIND TACHYKININS%REACTOME DATABASE ID RELEASE 66%10145521 Tachykinin receptors bind tachykinins GLOBAL GENOME NUCLEOTIDE EXCISION REPAIR (GG-NER)%REACTOME%R-RNO-5696399.1 Global Genome Nucleotide Excision Repair (GG-NER) CENTROSOME MATURATION%REACTOME%R-RNO-380287.1 Centrosome maturation CHROMATIN ORGANIZATION%REACTOME DATABASE ID RELEASE 66%10145803 Chromatin organization EXTENSION OF TELOMERES%REACTOME DATABASE ID RELEASE 66%10145111 Extension of Telomeres CDO IN MYOGENESIS%REACTOME DATABASE ID RELEASE 66%10145503 CDO in myogenesis GAP JUNCTION TRAFFICKING AND REGULATION%REACTOME DATABASE ID RELEASE 66%10145298 Gap junction trafficking and regulation GLUTATHIONE SYNTHESIS AND RECYCLING%REACTOME%R-RNO-174403.1 Glutathione synthesis and recycling INTERLEUKIN-3, INTERLEUKIN-5 AND GM-CSF SIGNALING%REACTOME DATABASE ID RELEASE 66%10145705 Interleukin-3, Interleukin-5 and GM-CSF signaling ACYL CHAIN REMODELLING OF PC%REACTOME%R-RNO-1482788.1 Acyl chain remodelling of PC INTERLEUKIN-1 SIGNALING%REACTOME%R-RNO-9020702.1 Interleukin-1 signaling G0 AND EARLY G1%REACTOME%R-RNO-1538133.1 G0 and Early G1 ACTIVATION OF CAMK IV%REACTOME%R-RNO-442745.1 Activation of CaMK IV ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%R-RNO-1296041.1 Activation of G protein gated Potassium channels DUAL INCISION IN TC-NER%REACTOME%R-RNO-6782135.1 Dual incision in TC-NER CYTOSOLIC TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 66%10144822 Cytosolic tRNA aminoacylation ELECTRON TRANSPORT FROM NADPH TO FERREDOXIN%REACTOME%R-RNO-2395516.1 Electron transport from NADPH to Ferredoxin VEGF LIGAND-RECEPTOR INTERACTIONS%REACTOME DATABASE ID RELEASE 66%10145339 VEGF ligand-receptor interactions YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION%REACTOME%R-RNO-2032785.1 YAP1- and WWTR1 (TAZ)-stimulated gene expression DNA REPAIR%REACTOME DATABASE ID RELEASE 66%10144763 DNA Repair REGULATION OF NECROPTOTIC CELL DEATH%REACTOME DATABASE ID RELEASE 66%10146017 Regulation of necroptotic cell death INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1%REACTOME DATABASE ID RELEASE 66%10145013 Inhibition of replication initiation of damaged DNA by RB1 E2F1 RECOGNITION OF DNA DAMAGE BY PCNA-CONTAINING REPLICATION COMPLEX%REACTOME DATABASE ID RELEASE 66%10146094 Recognition of DNA damage by PCNA-containing replication complex SYNAPTIC ADHESION-LIKE MOLECULES%REACTOME DATABASE ID RELEASE 66%10146209 Synaptic adhesion-like molecules VEGF BINDS TO VEGFR LEADING TO RECEPTOR DIMERIZATION%REACTOME DATABASE ID RELEASE 66%10145338 VEGF binds to VEGFR leading to receptor dimerization THE ACTIVATION OF ARYLSULFATASES%REACTOME DATABASE ID RELEASE 66%10145887 The activation of arylsulfatases LINOLEIC ACID (LA) METABOLISM%REACTOME DATABASE ID RELEASE 66%10145933 Linoleic acid (LA) metabolism FORMATION OF ANNULAR GAP JUNCTIONS%REACTOME%R-RNO-196025.1 Formation of annular gap junctions CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM%REACTOME DATABASE ID RELEASE 66%10145886 Chondroitin sulfate dermatan sulfate metabolism INTERLEUKIN-12 FAMILY SIGNALING%REACTOME%R-RNO-447115.1 Interleukin-12 family signaling TOLL LIKE RECEPTOR 10 (TLR10) CASCADE%REACTOME%R-RNO-168142.1 Toll Like Receptor 10 (TLR10) Cascade BIOSYNTHESIS OF ASPIRIN-TRIGGERED D-SERIES RESOLVINS%REACTOME%R-RNO-9020265.1 Biosynthesis of aspirin-triggered D-series resolvins ADENYLATE CYCLASE INHIBITORY PATHWAY%REACTOME DATABASE ID RELEASE 66%10145186 Adenylate cyclase inhibitory pathway HYDROLYSIS OF LPC%REACTOME%R-RNO-1483115.1 Hydrolysis of LPC PRE-NOTCH EXPRESSION AND PROCESSING%REACTOME DATABASE ID RELEASE 66%10145916 Pre-NOTCH Expression and Processing CD22 MEDIATED BCR REGULATION%REACTOME DATABASE ID RELEASE 66%10146141 CD22 mediated BCR regulation ACTIVATION OF NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%R-RNO-629602.1 Activation of Nicotinic Acetylcholine Receptors TRANSCRIPTION FROM MITOCHONDRIAL PROMOTERS%REACTOME DATABASE ID RELEASE 66%10145118 Transcription from mitochondrial promoters DOPAMINE RECEPTORS%REACTOME%R-RNO-390651.1 Dopamine receptors SYNTHESIS OF EPOXY (EET) AND DIHYDROXYEICOSATRIENOIC ACIDS (DHET)%REACTOME DATABASE ID RELEASE 66%10145947 Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK%REACTOME DATABASE ID RELEASE 66%10145383 Energy dependent regulation of mTOR by LKB1-AMPK BIOSYNTHESIS OF E-SERIES 18(S)-RESOLVINS%REACTOME%R-RNO-9018896.1 Biosynthesis of E-series 18(S)-resolvins SYNTHESIS OF PA%REACTOME DATABASE ID RELEASE 66%10144907 Synthesis of PA NOSTRIN MEDIATED ENOS TRAFFICKING%REACTOME%R-RNO-203641.1 NOSTRIN mediated eNOS trafficking DEPYRIMIDINATION%REACTOME DATABASE ID RELEASE 66%10144972 Depyrimidination PHYSIOLOGICAL FACTORS%REACTOME%R-RNO-5578768.1 Physiological factors JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1%REACTOME%R-RNO-450321.1 JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 DNA STRAND ELONGATION%REACTOME%R-RNO-69190.1 DNA strand elongation INTERFERON ALPHA BETA SIGNALING%REACTOME%R-RNO-909733.1 Interferon alpha beta signaling TOLL-LIKE RECEPTOR CASCADES%REACTOME DATABASE ID RELEASE 66%10145131 Toll-like Receptor Cascades RESOLUTION OF SISTER CHROMATID COHESION%REACTOME DATABASE ID RELEASE 66%10145894 Resolution of Sister Chromatid Cohesion GPVI-MEDIATED ACTIVATION CASCADE%REACTOME%R-RNO-114604.1 GPVI-mediated activation cascade NADE MODULATES DEATH SIGNALLING%REACTOME DATABASE ID RELEASE 66%10145330 NADE modulates death signalling RHO GTPASES ACTIVATE RHOTEKIN AND RHOPHILINS%REACTOME DATABASE ID RELEASE 66%10146121 RHO GTPases Activate Rhotekin and Rhophilins PROSTANOID LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145568 Prostanoid ligand receptors PACKAGING OF TELOMERE ENDS%REACTOME%R-RNO-171306.1 Packaging Of Telomere Ends ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING%REACTOME DATABASE ID RELEASE 66%10145740 Advanced glycosylation endproduct receptor signaling TP53 REGULATES TRANSCRIPTION OF CELL DEATH GENES%REACTOME%R-RNO-5633008.1 TP53 Regulates Transcription of Cell Death Genes FGFR2C LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 66%10145288 FGFR2c ligand binding and activation PLASMA LIPOPROTEIN ASSEMBLY%REACTOME%R-RNO-8963898.1 Plasma lipoprotein assembly ACTIVATED NTRK2 SIGNALS THROUGH FRS2 AND FRS3%REACTOME%R-RNO-9028731.1 Activated NTRK2 signals through FRS2 and FRS3 E2F MEDIATED REGULATION OF DNA REPLICATION%REACTOME DATABASE ID RELEASE 66%10145014 E2F mediated regulation of DNA replication TOLL LIKE RECEPTOR 2 (TLR2) CASCADE%REACTOME%R-RNO-181438.1 Toll Like Receptor 2 (TLR2) Cascade TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION%REACTOME%R-RNO-1474151.1 Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation RHO GTPASES ACTIVATE NADPH OXIDASES%REACTOME DATABASE ID RELEASE 66%10146047 RHO GTPases Activate NADPH Oxidases DOWNREGULATION OF ERBB2:ERBB3 SIGNALING%REACTOME%R-RNO-1358803.1 Downregulation of ERBB2:ERBB3 signaling CELL-CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 66%10145495 Cell-cell junction organization SYNTHESIS OF IPS IN THE NUCLEUS%REACTOME%R-RNO-1855191.1 Synthesis of IPs in the nucleus SYNTHESIS OF DNA%REACTOME DATABASE ID RELEASE 66%10144719 Synthesis of DNA SYNTHESIS OF BILE ACIDS AND BILE SALTS%REACTOME DATABASE ID RELEASE 66%10145312 Synthesis of bile acids and bile salts APOPTOTIC FACTOR-MEDIATED RESPONSE%REACTOME%R-RNO-111471.1 Apoptotic factor-mediated response GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT%REACTOME%R-RNO-72706.1 GTP hydrolysis and joining of the 60S ribosomal subunit INTRA-GOLGI AND RETROGRADE GOLGI-TO-ER TRAFFIC%REACTOME DATABASE ID RELEASE 66%10146192 Intra-Golgi and retrograde Golgi-to-ER traffic SIGNALING BY RECEPTOR TYROSINE KINASES%REACTOME DATABASE ID RELEASE 66%10144877 Signaling by Receptor Tyrosine Kinases TRANS-GOLGI NETWORK VESICLE BUDDING%REACTOME DATABASE ID RELEASE 66%10145468 trans-Golgi Network Vesicle Budding LIGAND-INDEPENDENT CASPASE ACTIVATION VIA DCC%REACTOME DATABASE ID RELEASE 66%10145489 Ligand-independent caspase activation via DCC IONOTROPIC ACTIVITY OF KAINATE RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145699 Ionotropic activity of kainate receptors SMAC-MEDIATED DISSOCIATION OF IAP:CASPASE COMPLEXES%REACTOME%R-RNO-111464.1 SMAC-mediated dissociation of IAP:caspase complexes MITOTIC G1-G1 S PHASES%REACTOME DATABASE ID RELEASE 66%10144725 Mitotic G1-G1 S phases HEME DEGRADATION%REACTOME%R-RNO-189483.1 Heme degradation BIOSYNTHESIS OF DPAN-3-DERIVED MARESINS%REACTOME%R-RNO-9026290.1 Biosynthesis of DPAn-3-derived maresins TP53 REGULATES TRANSCRIPTION OF ADDITIONAL CELL CYCLE GENES WHOSE EXACT ROLE IN THE P53 PATHWAY REMAIN UNCERTAIN%REACTOME%R-RNO-6804115.1 TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain FGFR3 LIGAND BINDING AND ACTIVATION%REACTOME%R-RNO-190239.1 FGFR3 ligand binding and activation MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 66%10145043 Muscle contraction DEATH RECEPTOR SIGNALLING%REACTOME DATABASE ID RELEASE 66%10144808 Death Receptor Signalling DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR)%REACTOME DATABASE ID RELEASE 66%10145798 Downstream signaling events of B Cell Receptor (BCR) TNFR1-INDUCED PROAPOPTOTIC SIGNALING%REACTOME DATABASE ID RELEASE 66%10144945 TNFR1-induced proapoptotic signaling KSRP (KHSRP) BINDS AND DESTABILIZES MRNA%REACTOME DATABASE ID RELEASE 66%10145696 KSRP (KHSRP) binds and destabilizes mRNA BIOSYNTHESIS OF PROTECTINS%REACTOME%R-RNO-9018681.1 Biosynthesis of protectins SIGNALING BY ERYTHROPOIETIN%REACTOME DATABASE ID RELEASE 66%10146295 Signaling by Erythropoietin DISINHIBITION OF SNARE FORMATION%REACTOME DATABASE ID RELEASE 66%10145035 Disinhibition of SNARE formation CATECHOLAMINE BIOSYNTHESIS%REACTOME%R-RNO-209905.1 Catecholamine biosynthesis TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES%REACTOME%R-RNO-425393.1 Transport of inorganic cations anions and amino acids oligopeptides SIGNAL ATTENUATION%REACTOME%R-RNO-74749.1 Signal attenuation NONHOMOLOGOUS END-JOINING (NHEJ)%REACTOME%R-RNO-5693571.1 Nonhomologous End-Joining (NHEJ) BASIGIN INTERACTIONS%REACTOME%R-RNO-210991.1 Basigin interactions SUMO IS CONJUGATED TO E1 (UBA2:SAE1)%REACTOME DATABASE ID RELEASE 66%10145983 SUMO is conjugated to E1 (UBA2:SAE1) NUCLEAR SIGNALING BY ERBB4%REACTOME%R-RNO-1251985.1 Nuclear signaling by ERBB4 LIPOPROTEIN METABOLISM%REACTOME DATABASE ID RELEASE 66%10145205 Lipoprotein metabolism CA ACTIVATED K+ CHANNELS%REACTOME DATABASE ID RELEASE 66%10145832 Ca activated K+ channels SYNTHESIS OF IPS IN THE ER LUMEN%REACTOME%R-RNO-1855231.1 Synthesis of IPs in the ER lumen LEUKOTRIENE RECEPTORS%REACTOME%R-RNO-391906.1 Leukotriene receptors CELL JUNCTION ORGANIZATION%REACTOME%R-RNO-446728.1 Cell junction organization PHOSPHORYLATION OF THE APC C%REACTOME DATABASE ID RELEASE 66%10145220 Phosphorylation of the APC C ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY%REACTOME DATABASE ID RELEASE 66%10145655 Zinc influx into cells by the SLC39 gene family P75 NTR RECEPTOR-MEDIATED SIGNALLING%REACTOME%R-RNO-193704.1 p75 NTR receptor-mediated signalling METABOLISM%REACTOME DATABASE ID RELEASE 66%10144767 Metabolism XBP1(S) ACTIVATES CHAPERONE GENES%REACTOME%R-RNO-381038.1 XBP1(S) activates chaperone genes COPI-MEDIATED ANTEROGRADE TRANSPORT%REACTOME%R-RNO-6807878.1 COPI-mediated anterograde transport INTERLEUKIN-12 SIGNALING%REACTOME DATABASE ID RELEASE 66%10145676 Interleukin-12 signaling NONSENSE-MEDIATED DECAY (NMD)%REACTOME%R-RNO-927802.1 Nonsense-Mediated Decay (NMD) REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE%REACTOME%R-RNO-3371453.1 Regulation of HSF1-mediated heat shock response TRANSCRIPTIONAL REGULATION BY TP53%REACTOME DATABASE ID RELEASE 66%10144748 Transcriptional Regulation by TP53 ROBO RECEPTORS BIND AKAP5%REACTOME%R-RNO-9010642.1 ROBO receptors bind AKAP5 INTERLEUKIN-35 SIGNALLING%REACTOME DATABASE ID RELEASE 66%10145680 Interleukin-35 Signalling TRANSLATION%REACTOME%R-RNO-72766.1 Translation TP53 REGULATES TRANSCRIPTION OF CASPASE ACTIVATORS AND CASPASES%REACTOME%R-RNO-6803207.1 TP53 Regulates Transcription of Caspase Activators and Caspases VISUAL PHOTOTRANSDUCTION%REACTOME%R-RNO-2187338.1 Visual phototransduction ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS%REACTOME DATABASE ID RELEASE 66%10145358 Role of phospholipids in phagocytosis TRAF6-MEDIATED INDUCTION OF TAK1 COMPLEX WITHIN TLR4 COMPLEX%REACTOME DATABASE ID RELEASE 66%10145767 TRAF6-mediated induction of TAK1 complex within TLR4 complex TRKA ACTIVATION BY NGF%REACTOME DATABASE ID RELEASE 66%10145140 TRKA activation by NGF AQUAPORIN-MEDIATED TRANSPORT%REACTOME DATABASE ID RELEASE 66%10145007 Aquaporin-mediated transport CHK1 CHK2(CDS1) MEDIATED INACTIVATION OF CYCLIN B:CDK1 COMPLEX%REACTOME%R-RNO-75035.1 Chk1 Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex NEURONAL SYSTEM%REACTOME DATABASE ID RELEASE 66%10144791 Neuronal System SIGNAL REGULATORY PROTEIN FAMILY INTERACTIONS%REACTOME DATABASE ID RELEASE 66%10145430 Signal regulatory protein family interactions RHO GTPASES ACTIVATE ROCKS%REACTOME%R-RNO-5627117.1 RHO GTPases Activate ROCKs TRIF(TICAM1)-MEDIATED TLR4 SIGNALING%REACTOME DATABASE ID RELEASE 66%10145138 TRIF(TICAM1)-mediated TLR4 signaling REGULATION OF TP53 DEGRADATION%REACTOME DATABASE ID RELEASE 66%10145361 Regulation of TP53 Degradation VITAMIN B1 (THIAMIN) METABOLISM%REACTOME%R-RNO-196819.1 Vitamin B1 (thiamin) metabolism E3 UBIQUITIN LIGASES UBIQUITINATE TARGET PROTEINS%REACTOME%R-RNO-8866654.1 E3 ubiquitin ligases ubiquitinate target proteins RESOLUTION OF D-LOOP STRUCTURES THROUGH SYNTHESIS-DEPENDENT STRAND ANNEALING (SDSA)%REACTOME DATABASE ID RELEASE 66%10146147 Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) TWIK RELATED POTASSIUM CHANNEL (TREK)%REACTOME DATABASE ID RELEASE 66%10145838 TWIK related potassium channel (TREK) REGULATION OF BETA-CELL DEVELOPMENT%REACTOME DATABASE ID RELEASE 66%10145438 Regulation of beta-cell development PROCESSIVE SYNTHESIS ON THE LAGGING STRAND%REACTOME%R-RNO-69183.1 Processive synthesis on the lagging strand CARBOXYTERMINAL POST-TRANSLATIONAL MODIFICATIONS OF TUBULIN%REACTOME%R-RNO-8955332.1 Carboxyterminal post-translational modifications of tubulin APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME DATABASE ID RELEASE 66%10145218 APC C:Cdc20 mediated degradation of mitotic proteins DEGRADATION OF AXIN%REACTOME DATABASE ID RELEASE 66%10146020 Degradation of AXIN DNA DAMAGE BYPASS%REACTOME DATABASE ID RELEASE 66%10144978 DNA Damage Bypass SIGNALING BY ACTIVIN%REACTOME%R-RNO-1502540.1 Signaling by Activin CELL DIVISION%REACTOME%R-RNO-68884.1 cell division OAS ANTIVIRAL RESPONSE%REACTOME DATABASE ID RELEASE 66%10146284 OAS antiviral response PKA-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%R-RNO-111931.1 PKA-mediated phosphorylation of CREB RHO GTPASES ACTIVATE WASPS AND WAVES%REACTOME DATABASE ID RELEASE 66%10145928 RHO GTPases Activate WASPs and WAVEs SNRNP ASSEMBLY%REACTOME%R-RNO-191859.1 snRNP Assembly CHROMOSOME MAINTENANCE%REACTOME DATABASE ID RELEASE 66%10145113 Chromosome Maintenance TRANSCRIPTIONAL REGULATION BY RUNX1%REACTOME DATABASE ID RELEASE 66%10146236 Transcriptional regulation by RUNX1 AFLATOXIN ACTIVATION AND DETOXIFICATION%REACTOME DATABASE ID RELEASE 66%10145070 Aflatoxin activation and detoxification SEROTONIN AND MELATONIN BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 66%10145426 Serotonin and melatonin biosynthesis N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI%REACTOME%R-RNO-975576.1 N-glycan antennae elongation in the medial trans-Golgi HYDROLYSIS OF LPE%REACTOME%R-RNO-1483152.1 Hydrolysis of LPE ACTIVATED NTRK3 SIGNALS THROUGH PI3K%REACTOME%R-RNO-9603381.1 Activated NTRK3 signals through PI3K SIGNAL TRANSDUCTION BY L1%REACTOME%R-RNO-445144.1 Signal transduction by L1 PDE3B SIGNALLING%REACTOME%R-RNO-165160.1 PDE3B signalling IRS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 66%10144880 IRS-mediated signalling TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE%REACTOME DATABASE ID RELEASE 66%10145154 Toll Like Receptor 7 8 (TLR7 8) Cascade ATP SENSITIVE POTASSIUM CHANNELS%REACTOME DATABASE ID RELEASE 66%10145831 ATP sensitive Potassium channels COOPERATION OF PDCL (PHLP1) AND TRIC CCT IN G-PROTEIN BETA FOLDING%REACTOME DATABASE ID RELEASE 66%10146196 Cooperation of PDCL (PhLP1) and TRiC CCT in G-protein beta folding NRIF SIGNALS CELL DEATH FROM THE NUCLEUS%REACTOME DATABASE ID RELEASE 66%10145334 NRIF signals cell death from the nucleus CD209 (DC-SIGN) SIGNALING%REACTOME%R-RNO-5621575.1 CD209 (DC-SIGN) signaling ANTIMICROBIAL PEPTIDES%REACTOME%R-RNO-6803157.1 Antimicrobial peptides VITAMIN C (ASCORBATE) METABOLISM%REACTOME DATABASE ID RELEASE 66%10145368 Vitamin C (ascorbate) metabolism DEUBIQUITINATION%REACTOME DATABASE ID RELEASE 66%10145726 Deubiquitination AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS%REACTOME DATABASE ID RELEASE 66%10145371 AKT phosphorylates targets in the nucleus INFLAMMASOMES%REACTOME DATABASE ID RELEASE 66%10145733 Inflammasomes PROCESSING OF SMDT1%REACTOME%R-RNO-8949664.1 Processing of SMDT1 COPII-MEDIATED VESICLE TRANSPORT%REACTOME%R-RNO-204005.1 COPII-mediated vesicle transport IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME DATABASE ID RELEASE 66%10145773 IRAK2 mediated activation of TAK1 complex upon TLR7 8 or 9 stimulation BIOSYNTHESIS OF DPAN-3 SPMS%REACTOME%R-RNO-9025094.1 Biosynthesis of DPAn-3 SPMs SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS%REACTOME DATABASE ID RELEASE 66%10144939 SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE%REACTOME%R-RNO-4641262.1 Disassembly of the destruction complex and recruitment of AXIN to the membrane COLLAGEN DEGRADATION%REACTOME DATABASE ID RELEASE 66%10145855 Collagen degradation PROTEIN REPAIR%REACTOME%R-RNO-5676934.1 Protein repair ACROSOME REACTION%REACTOME%R-RNO-1300645.1 Acrosome Reaction PKA ACTIVATION%REACTOME%R-RNO-163615.1 PKA activation PROCESSING OF INTRONLESS PRE-MRNAS%REACTOME DATABASE ID RELEASE 66%10144941 Processing of Intronless Pre-mRNAs NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 66%10145491 Netrin-1 signaling FMO OXIDISES NUCLEOPHILES%REACTOME%R-RNO-217271.1 FMO oxidises nucleophiles ASTROCYTIC GLUTAMATE-GLUTAMINE UPTAKE AND METABOLISM%REACTOME%R-RNO-210455.1 Astrocytic Glutamate-Glutamine Uptake And Metabolism RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES%REACTOME%R-RNO-380270.1 Recruitment of mitotic centrosome proteins and complexes METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS%REACTOME%R-RNO-196849.1 Metabolism of water-soluble vitamins and cofactors CELLULAR RESPONSE TO HYPOXIA%REACTOME%R-RNO-2262749.1 Cellular response to hypoxia PHOSPHOLIPASE C-MEDIATED CASCADE; FGFR4%REACTOME DATABASE ID RELEASE 66%10146101 Phospholipase C-mediated cascade; FGFR4 CROSSLINKING OF COLLAGEN FIBRILS%REACTOME DATABASE ID RELEASE 66%10145923 Crosslinking of collagen fibrils CELL SURFACE INTERACTIONS AT THE VASCULAR WALL%REACTOME DATABASE ID RELEASE 66%10145033 Cell surface interactions at the vascular wall FORMATION OF THE EDITOSOME%REACTOME DATABASE ID RELEASE 66%10144942 Formation of the Editosome ACTIVATION OF NOXA AND TRANSLOCATION TO MITOCHONDRIA%REACTOME DATABASE ID RELEASE 66%10145050 Activation of NOXA and translocation to mitochondria REGULATION OF THYROID HORMONE ACTIVITY%REACTOME DATABASE ID RELEASE 66%10145423 Regulation of thyroid hormone activity SODIUM-COUPLED SULPHATE, DI- AND TRI-CARBOXYLATE TRANSPORTERS%REACTOME DATABASE ID RELEASE 66%10145648 Sodium-coupled sulphate, di- and tri-carboxylate transporters APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1%REACTOME%R-RNO-174178.1 APC C:Cdh1 mediated degradation of Cdc20 and other APC C:Cdh1 targeted proteins in late mitosis early G1 BIOSYNTHESIS OF DPAN-3-DERIVED 13-SERIES RESOLVINS%REACTOME%R-RNO-9026403.1 Biosynthesis of DPAn-3-derived 13-series resolvins TP53 REGULATES TRANSCRIPTION OF DEATH RECEPTORS AND LIGANDS%REACTOME%R-RNO-6803211.1 TP53 Regulates Transcription of Death Receptors and Ligands O2 CO2 EXCHANGE IN ERYTHROCYTES%REACTOME DATABASE ID RELEASE 66%10145818 O2 CO2 exchange in erythrocytes FGFR2B LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 66%10145290 FGFR2b ligand binding and activation RAF ACTIVATION%REACTOME DATABASE ID RELEASE 66%10146124 RAF activation ARMS-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 66%10145180 ARMS-mediated activation GRB2 EVENTS IN EGFR SIGNALING%REACTOME%R-RNO-179812.1 GRB2 events in EGFR signaling HS-GAG BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 66%10145730 HS-GAG biosynthesis STAT6-MEDIATED INDUCTION OF CHEMOKINES%REACTOME%R-RNO-3249367.1 STAT6-mediated induction of chemokines DEGRADATION OF GABA%REACTOME DATABASE ID RELEASE 66%10145745 Degradation of GABA BIOSYNTHESIS OF E-SERIES 18(R)-RESOLVINS%REACTOME DATABASE ID RELEASE 66%10146300 Biosynthesis of E-series 18(R)-resolvins DNA DOUBLE STRAND BREAK RESPONSE%REACTOME%R-RNO-5693606.1 DNA Double Strand Break Response REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN%REACTOME DATABASE ID RELEASE 66%10145192 Regulation of Glucokinase by Glucokinase Regulatory Protein CYTOSOLIC SULFONATION OF SMALL MOLECULES%REACTOME%R-RNO-156584.1 Cytosolic sulfonation of small molecules CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS%REACTOME%R-RNO-264870.1 Caspase-mediated cleavage of cytoskeletal proteins DISPLACEMENT OF DNA GLYCOSYLASE BY APEX1%REACTOME%R-RNO-110357.1 Displacement of DNA glycosylase by APEX1 NICOTINAMIDE SALVAGING%REACTOME%R-RNO-197264.1 Nicotinamide salvaging TELOMERE MAINTENANCE%REACTOME DATABASE ID RELEASE 66%10145112 Telomere Maintenance RECYCLING OF EIF2:GDP%REACTOME%R-RNO-72731.1 Recycling of eIF2:GDP CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE%REACTOME DATABASE ID RELEASE 66%10144920 Cytochrome P450 - arranged by substrate type UB-SPECIFIC PROCESSING PROTEASES%REACTOME%R-RNO-5689880.1 Ub-specific processing proteases O-GLYCOSYLATION OF TSR DOMAIN-CONTAINING PROTEINS%REACTOME DATABASE ID RELEASE 66%10146044 O-glycosylation of TSR domain-containing proteins TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT%REACTOME DATABASE ID RELEASE 66%10144895 Transport of Mature mRNA derived from an Intron-Containing Transcript MET ACTIVATES PI3K AKT SIGNALING%REACTOME%R-RNO-8851907.1 MET activates PI3K AKT signaling NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME DATABASE ID RELEASE 66%10145957 NOTCH2 intracellular domain regulates transcription RET SIGNALING%REACTOME DATABASE ID RELEASE 66%10146221 RET signaling CLATHRIN-MEDIATED ENDOCYTOSIS%REACTOME DATABASE ID RELEASE 66%10146228 Clathrin-mediated endocytosis FGFR2 ALTERNATIVE SPLICING%REACTOME%R-RNO-6803529.1 FGFR2 alternative splicing NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME DATABASE ID RELEASE 66%10145624 Negative epigenetic regulation of rRNA expression C-TYPE LECTIN RECEPTORS (CLRS)%REACTOME%R-RNO-5621481.1 C-type lectin receptors (CLRs) TRANSPORT OF CONNEXINS ALONG THE SECRETORY PATHWAY%REACTOME DATABASE ID RELEASE 66%215126 Transport of connexins along the secretory pathway BICARBONATE TRANSPORTERS%REACTOME DATABASE ID RELEASE 66%10145616 Bicarbonate transporters HEMOSTASIS%REACTOME DATABASE ID RELEASE 66%10145028 Hemostasis BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS%REACTOME%R-RNO-111453.1 BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members POSITIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%R-RNO-5250913.1 Positive epigenetic regulation of rRNA expression DEGRADATION OF CYSTEINE AND HOMOCYSTEINE%REACTOME DATABASE ID RELEASE 66%10145890 Degradation of cysteine and homocysteine TRANSPORT OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 66%10144953 Transport of small molecules INTERLEUKIN-1 PROCESSING%REACTOME%R-RNO-448706.1 Interleukin-1 processing FC EPSILON RECEPTOR (FCERI) SIGNALING%REACTOME DATABASE ID RELEASE 66%10145167 Fc epsilon receptor (FCERI) signaling SEROTONIN RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145563 Serotonin receptors REVERSAL OF ALKYLATION DAMAGE BY DNA DIOXYGENASES%REACTOME DATABASE ID RELEASE 66%10146230 Reversal of alkylation damage by DNA dioxygenases PROTEIN-PROTEIN INTERACTIONS AT SYNAPSES%REACTOME%R-RNO-6794362.1 Protein-protein interactions at synapses MET PROMOTES CELL MOTILITY%REACTOME DATABASE ID RELEASE 66%10146247 MET promotes cell motility MRNA EDITING: C TO U CONVERSION%REACTOME%R-RNO-72200.1 mRNA Editing: C to U Conversion ECM PROTEOGLYCANS%REACTOME%R-RNO-3000178.1 ECM proteoglycans P38MAPK EVENTS%REACTOME DATABASE ID RELEASE 66%10145201 p38MAPK events INNATE IMMUNE SYSTEM%REACTOME%R-RNO-168249.1 Innate Immune System TRANSMISSION ACROSS ELECTRICAL SYNAPSES%REACTOME DATABASE ID RELEASE 66%10145508 Transmission across Electrical Synapses EPHA-MEDIATED GROWTH CONE COLLAPSE%REACTOME DATABASE ID RELEASE 66%10146028 EPHA-mediated growth cone collapse IRF3 MEDIATED ACTIVATION OF TYPE 1 IFN%REACTOME%R-RNO-1606341.1 IRF3 mediated activation of type 1 IFN HDL REMODELING%REACTOME DATABASE ID RELEASE 66%10145453 HDL remodeling SIGNALING BY GPCR%REACTOME DATABASE ID RELEASE 66%10144870 Signaling by GPCR ELASTIC FIBRE FORMATION%REACTOME%R-RNO-1566948.1 Elastic fibre formation FGFR4 LIGAND BINDING AND ACTIVATION%REACTOME%R-RNO-190322.1 FGFR4 ligand binding and activation INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION%REACTOME%R-RNO-400508.1 Incretin synthesis, secretion, and inactivation METALLOTHIONEINS BIND METALS%REACTOME%R-RNO-5661231.1 Metallothioneins bind metals INSULIN PROCESSING%REACTOME DATABASE ID RELEASE 66%10145456 Insulin processing ANCHORING FIBRIL FORMATION%REACTOME%R-RNO-2214320.1 Anchoring fibril formation MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF UNSATURATED FATTY ACIDS%REACTOME DATABASE ID RELEASE 66%10144949 mitochondrial fatty acid beta-oxidation of unsaturated fatty acids SCAVENGING BY CLASS A RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145956 Scavenging by Class A Receptors CLATHRIN DERIVED VESICLE BUDDING%REACTOME%R-RNO-421837.1 Clathrin derived vesicle budding SCAVENGING BY CLASS H RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145959 Scavenging by Class H Receptors POLB-DEPENDENT LONG PATCH BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 66%10146093 POLB-Dependent Long Patch Base Excision Repair MACROAUTOPHAGY%REACTOME%R-RNO-1632852.1 Macroautophagy GOLGI ASSOCIATED VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 66%10145614 Golgi Associated Vesicle Biogenesis HEDGEHOG LIGAND BIOGENESIS%REACTOME%R-RNO-5358346.1 Hedgehog ligand biogenesis SIGNALING BY NTRK3 (TRKC)%REACTOME DATABASE ID RELEASE 66%10146326 Signaling by NTRK3 (TRKC) SIGNALING BY NTRK2 (TRKB)%REACTOME DATABASE ID RELEASE 66%10146316 Signaling by NTRK2 (TRKB) NEGATIVE REGULATION OF NOTCH4 SIGNALING%REACTOME DATABASE ID RELEASE 66%10146331 Negative regulation of NOTCH4 signaling ERBB2 ACTIVATES PTK6 SIGNALING%REACTOME%R-RNO-8847993.1 ERBB2 Activates PTK6 Signaling WNT MEDIATED ACTIVATION OF DVL%REACTOME DATABASE ID RELEASE 66%10145393 WNT mediated activation of DVL DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY%REACTOME%R-RNO-2173795.1 Downregulation of SMAD2 3:SMAD4 transcriptional activity REGULATION OF IGF ACTIVITY BY IGFBP%REACTOME%R-RNO-381426.1 Regulation of IGF Activity by IGFBP EUKARYOTIC TRANSLATION TERMINATION%REACTOME DATABASE ID RELEASE 66%10146146 Eukaryotic Translation Termination ACTIVATED NTRK3 SIGNALS THROUGH PLCG1%REACTOME DATABASE ID RELEASE 66%10146327 Activated NTRK3 signals through PLCG1 THE NLRP1 INFLAMMASOME%REACTOME DATABASE ID RELEASE 66%10145732 The NLRP1 inflammasome SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP)%REACTOME%R-RNO-400511.1 Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER%REACTOME%R-RNO-76061.1 RNA Polymerase III Transcription Initiation From Type 1 Promoter TRANSCRIPTIONAL REGULATION BY MECP2%REACTOME%R-RNO-8986944.1 Transcriptional Regulation by MECP2 MITOCHONDRIAL TRANSLATION%REACTOME%R-RNO-5368287.1 Mitochondrial translation PROTEIN LOCALIZATION%REACTOME DATABASE ID RELEASE 66%10146283 Protein localization CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX%REACTOME%R-RNO-68689.1 CDC6 association with the ORC:origin complex RESOLUTION OF D-LOOP STRUCTURES%REACTOME%R-RNO-5693537.1 Resolution of D-Loop Structures SPHINGOLIPID DE NOVO BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 66%10145630 Sphingolipid de novo biosynthesis CLEARANCE OF DOPAMINE%REACTOME%R-RNO-379401.1 Clearance of dopamine GABA SYNTHESIS%REACTOME DATABASE ID RELEASE 66%10145746 GABA synthesis SUMOYLATION OF TRANSCRIPTION COFACTORS%REACTOME DATABASE ID RELEASE 66%10145995 SUMOylation of transcription cofactors SIGNALING BY WNT%REACTOME DATABASE ID RELEASE 66%10145342 Signaling by WNT ESTROGEN BIOSYNTHESIS%REACTOME%R-RNO-193144.1 Estrogen biosynthesis SUMOYLATION OF CHROMATIN ORGANIZATION PROTEINS%REACTOME%R-RNO-4551638.1 SUMOylation of chromatin organization proteins CLEAVAGE OF THE DAMAGED PURINE%REACTOME DATABASE ID RELEASE 66%10144974 Cleavage of the damaged purine DEPOLYMERISATION OF THE NUCLEAR LAMINA%REACTOME DATABASE ID RELEASE 66%10146031 Depolymerisation of the Nuclear Lamina EPIGENETIC REGULATION OF GENE EXPRESSION%REACTOME DATABASE ID RELEASE 66%10145445 Epigenetic regulation of gene expression REACTIONS SPECIFIC TO THE HYBRID N-GLYCAN SYNTHESIS PATHWAY%REACTOME%R-RNO-975574.1 Reactions specific to the hybrid N-glycan synthesis pathway RHO GTPASES ACTIVATE PAKS%REACTOME%R-RNO-5627123.1 RHO GTPases activate PAKs DEGRADATION OF DVL%REACTOME DATABASE ID RELEASE 66%10145877 Degradation of DVL TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS%REACTOME DATABASE ID RELEASE 66%10145193 TGF-beta receptor signaling activates SMADs PYRUVATE METABOLISM%REACTOME%R-RNO-70268.1 Pyruvate metabolism PLATELET ACTIVATION, SIGNALING AND AGGREGATION%REACTOME DATABASE ID RELEASE 66%10145027 Platelet activation, signaling and aggregation LOSS OF NLP FROM MITOTIC CENTROSOMES%REACTOME%R-RNO-380259.1 Loss of Nlp from mitotic centrosomes CAM PATHWAY%REACTOME DATABASE ID RELEASE 66%10144992 CaM pathway SIGNALING BY SCF-KIT%REACTOME DATABASE ID RELEASE 66%10145420 Signaling by SCF-KIT TIGHT JUNCTION INTERACTIONS%REACTOME%R-RNO-420029.1 Tight junction interactions NUCLEOTIDE METABOLISM%REACTOME DATABASE ID RELEASE 66%10144816 Nucleotide metabolism INHIBITION OF ADENYLATE CYCLASE PATHWAY%REACTOME%R-RNO-997269.1 Inhibition of adenylate cyclase pathway RNA POLYMERASE II TRANSCRIBES SNRNA GENES%REACTOME DATABASE ID RELEASE 66%10146187 RNA polymerase II transcribes snRNA genes MRNA DECAY BY 3' TO 5' EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 66%10145639 mRNA decay by 3' to 5' exoribonuclease AMINE-DERIVED HORMONES%REACTOME%R-RNO-209776.1 Amine-derived hormones PROGRESSIVE TRIMMING OF ALPHA-1,2-LINKED MANNOSE RESIDUES FROM MAN9 8 7GLCNAC2 TO PRODUCE MAN5GLCNAC2%REACTOME%R-RNO-964827.1 Progressive trimming of alpha-1,2-linked mannose residues from Man9 8 7GlcNAc2 to produce Man5GlcNAc2 AMINO ACID AND DERIVATIVE METABOLISM%REACTOME%R-RNO-71291.1 Amino acid and derivative metabolism INOSITOL PHOSPHATE METABOLISM%REACTOME%R-RNO-1483249.1 Inositol phosphate metabolism FORMATION OF ATP BY CHEMIOSMOTIC COUPLING%REACTOME DATABASE ID RELEASE 66%10145126 Formation of ATP by chemiosmotic coupling ACTIVATION OF SMO%REACTOME DATABASE ID RELEASE 66%10146091 Activation of SMO GLI3 IS PROCESSED TO GLI3R BY THE PROTEASOME%REACTOME DATABASE ID RELEASE 66%10146075 GLI3 is processed to GLI3R by the proteasome RELEASE OF HH-NP FROM THE SECRETING CELL%REACTOME DATABASE ID RELEASE 66%10146062 Release of Hh-Np from the secreting cell ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES%REACTOME%R-RNO-2022090.1 Assembly of collagen fibrils and other multimeric structures PEROXISOMAL PROTEIN IMPORT%REACTOME DATABASE ID RELEASE 66%10146282 Peroxisomal protein import RECYCLING PATHWAY OF L1%REACTOME DATABASE ID RELEASE 66%10145501 Recycling pathway of L1 VASOPRESSIN REGULATES RENAL WATER HOMEOSTASIS VIA AQUAPORINS%REACTOME%R-RNO-432040.1 Vasopressin regulates renal water homeostasis via Aquaporins PI5P REGULATES TP53 ACETYLATION%REACTOME%R-RNO-6811555.1 PI5P Regulates TP53 Acetylation HYPUSINYLATION%REACTOME%R-RNO-204626.1 Hypusinylation UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1%REACTOME DATABASE ID RELEASE 66%10144899 Ubiquitin-dependent degradation of Cyclin D1 VEGFA-VEGFR2 PATHWAY%REACTOME DATABASE ID RELEASE 66%10145272 VEGFA-VEGFR2 Pathway TRANSCRIPTIONAL REGULATION BY RUNX3%REACTOME%R-RNO-8878159.1 Transcriptional regulation by RUNX3 TP53 REGULATES TRANSCRIPTION OF DNA REPAIR GENES%REACTOME DATABASE ID RELEASE 66%10146165 TP53 Regulates Transcription of DNA Repair Genes PI-3K CASCADE:FGFR2%REACTOME DATABASE ID RELEASE 66%10145254 PI-3K cascade:FGFR2 TRANSLESION SYNTHESIS BY REV1%REACTOME DATABASE ID RELEASE 66%10144976 Translesion synthesis by REV1 SHC1 EVENTS IN ERBB4 SIGNALING%REACTOME DATABASE ID RELEASE 66%10145825 SHC1 events in ERBB4 signaling TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM%REACTOME DATABASE ID RELEASE 66%10144896 Transport of Mature Transcript to Cytoplasm CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 66%10144717 CDT1 association with the CDC6:ORC:origin complex ACTIVATION OF BMF AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%R-RNO-139910.1 Activation of BMF and translocation to mitochondria CELL CYCLE, MITOTIC%REACTOME DATABASE ID RELEASE 66%10144721 Cell Cycle, Mitotic NEGATIVE REGULATION OF MET ACTIVITY%REACTOME%R-RNO-6807004.1 Negative regulation of MET activity MTOR SIGNALLING%REACTOME DATABASE ID RELEASE 66%10145128 mTOR signalling PURINE CATABOLISM%REACTOME%R-RNO-74259.1 Purine catabolism PHENYLALANINE AND TYROSINE CATABOLISM%REACTOME%R-RNO-71182.1 Phenylalanine and tyrosine catabolism SYNTHESIS OF DIPHTHAMIDE-EEF2%REACTOME DATABASE ID RELEASE 66%10146058 Synthesis of diphthamide-EEF2 TRIGLYCERIDE CATABOLISM%REACTOME%R-RNO-163560.1 Triglyceride catabolism CD28 CO-STIMULATION%REACTOME DATABASE ID RELEASE 66%10145354 CD28 co-stimulation REMOVAL OF AMINOTERMINAL PROPEPTIDES FROM GAMMA-CARBOXYLATED PROTEINS%REACTOME%R-RNO-159782.1 Removal of aminoterminal propeptides from gamma-carboxylated proteins EGFR TRANSACTIVATION BY GASTRIN%REACTOME%R-RNO-2179392.1 EGFR Transactivation by Gastrin GENE SILENCING BY RNA%REACTOME DATABASE ID RELEASE 66%10145435 Gene Silencing by RNA RUNX1 REGULATES GENES INVOLVED IN MEGAKARYOCYTE DIFFERENTIATION AND PLATELET FUNCTION%REACTOME%R-RNO-8936459.1 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function ONCOGENE INDUCED SENESCENCE%REACTOME DATABASE ID RELEASE 66%10145265 Oncogene Induced Senescence BIOSYNTHESIS OF MARESIN CONJUGATES IN TISSUE REGENERATION (MCTR)%REACTOME DATABASE ID RELEASE 66%10146313 Biosynthesis of maresin conjugates in tissue regeneration (MCTR) ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS%REACTOME DATABASE ID RELEASE 66%10145721 Acetylcholine binding and downstream events LIPID PARTICLE ORGANIZATION%REACTOME%R-RNO-8964572.1 Lipid particle organization TYPE I HEMIDESMOSOME ASSEMBLY%REACTOME DATABASE ID RELEASE 66%10145647 Type I hemidesmosome assembly METABOLISM OF INGESTED MESEO2H INTO MESEH%REACTOME%R-RNO-5263617.1 Metabolism of ingested MeSeO2H into MeSeH PROTEIN METHYLATION%REACTOME%R-RNO-8876725.1 Protein methylation SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE%REACTOME DATABASE ID RELEASE 66%10145901 Synthesis of PIPs at the Golgi membrane LAMININ INTERACTIONS%REACTOME DATABASE ID RELEASE 66%10145448 Laminin interactions SMAC BINDS TO IAPS%REACTOME%R-RNO-111463.1 SMAC binds to IAPs NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING%REACTOME%R-RNO-936440.1 Negative regulators of RIG-I MDA5 signaling HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM%REACTOME DATABASE ID RELEASE 66%10145731 Heparan sulfate heparin (HS-GAG) metabolism APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS%REACTOME DATABASE ID RELEASE 66%10145386 Apoptotic cleavage of cell adhesion proteins ASPARAGINE N-LINKED GLYCOSYLATION%REACTOME%R-RNO-446203.1 Asparagine N-linked glycosylation FORMATION OF FIBRIN CLOT (CLOTTING CASCADE)%REACTOME%R-RNO-140877.1 Formation of Fibrin Clot (Clotting Cascade) CD28 DEPENDENT PI3K AKT SIGNALING%REACTOME%R-RNO-389357.1 CD28 dependent PI3K Akt signaling TYSND1 CLEAVES PEROXISOMAL PROTEINS%REACTOME DATABASE ID RELEASE 66%10146324 TYSND1 cleaves peroxisomal proteins INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX%REACTOME%R-RNO-141430.1 Inactivation of APC C via direct inhibition of the APC C complex GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION%REACTOME%R-RNO-162658.1 Golgi Cisternae Pericentriolar Stack Reorganization LYSOSOME VESICLE BIOGENESIS%REACTOME%R-RNO-432720.1 Lysosome Vesicle Biogenesis PD-1 SIGNALING%REACTOME%R-RNO-389948.1 PD-1 signaling TRANSPORT OF BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS%REACTOME%R-RNO-425366.1 Transport of bile salts and organic acids, metal ions and amine compounds SIGNALLING TO RAS%REACTOME DATABASE ID RELEASE 66%10145202 Signalling to RAS ACTIVATION OF NF-KAPPAB IN B CELLS%REACTOME%R-RNO-1169091.1 Activation of NF-kappaB in B cells NUCLEOSOME ASSEMBLY%REACTOME%R-RNO-774815.1 Nucleosome assembly DDX58 IFIH1-MEDIATED INDUCTION OF INTERFERON-ALPHA BETA%REACTOME%R-RNO-168928.1 DDX58 IFIH1-mediated induction of interferon-alpha beta EGFR DOWNREGULATION%REACTOME DATABASE ID RELEASE 66%10145266 EGFR downregulation INTERLEUKIN-1 FAMILY SIGNALING%REACTOME DATABASE ID RELEASE 66%10145170 Interleukin-1 family signaling SUMOYLATION OF INTRACELLULAR RECEPTORS%REACTOME%R-RNO-4090294.1 SUMOylation of intracellular receptors RUNX3 REGULATES P14-ARF%REACTOME DATABASE ID RELEASE 66%10146279 RUNX3 regulates p14-ARF ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS%REACTOME DATABASE ID RELEASE 66%10145174 ZBP1(DAI) mediated induction of type I IFNs PROTON OLIGOPEPTIDE COTRANSPORTERS%REACTOME DATABASE ID RELEASE 66%10145629 Proton oligopeptide cotransporters METALLOPROTEASE DUBS%REACTOME DATABASE ID RELEASE 66%10146145 Metalloprotease DUBs ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION%REACTOME%R-RNO-450302.1 activated TAK1 mediates p38 MAPK activation NEGATIVE FEEDBACK REGULATION OF MAPK PATHWAY%REACTOME%R-RNO-5674499.1 Negative feedback regulation of MAPK pathway ALPHA-OXIDATION OF PHYTANATE%REACTOME DATABASE ID RELEASE 66%10145549 Alpha-oxidation of phytanate LIGAND-DEPENDENT CASPASE ACTIVATION%REACTOME DATABASE ID RELEASE 66%10144860 Ligand-dependent caspase activation PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE%REACTOME DATABASE ID RELEASE 66%10144782 Pyruvate metabolism and Citric Acid (TCA) cycle CD28 DEPENDENT VAV1 PATHWAY%REACTOME DATABASE ID RELEASE 66%10145542 CD28 dependent Vav1 pathway AMINE LIGAND-BINDING RECEPTORS%REACTOME%R-RNO-375280.1 Amine ligand-binding receptors MRNA DECAY BY 5' TO 3' EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 66%10145636 mRNA decay by 5' to 3' exoribonuclease MOLYBDENUM COFACTOR BIOSYNTHESIS%REACTOME%R-RNO-947581.1 Molybdenum cofactor biosynthesis TRANSLESION SYNTHESIS BY Y FAMILY DNA POLYMERASES BYPASSES LESIONS ON DNA TEMPLATE%REACTOME DATABASE ID RELEASE 66%10144977 Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template HISTIDINE, LYSINE, PHENYLALANINE, TYROSINE, PROLINE AND TRYPTOPHAN CATABOLISM%REACTOME DATABASE ID RELEASE 66%10144795 Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism SPERM MOTILITY AND TAXES%REACTOME%R-RNO-1300642.1 Sperm Motility And Taxes ENZYMATIC DEGRADATION OF DOPAMINE BY COMT%REACTOME DATABASE ID RELEASE 66%10145520 Enzymatic degradation of dopamine by COMT REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE%REACTOME%R-RNO-176408.1 Regulation of APC C activators between G1 S and early anaphase RNA POLYMERASE III TRANSCRIPTION%REACTOME%R-RNO-74158.1 RNA Polymerase III Transcription ACTIVATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME DATABASE ID RELEASE 66%10144871 Activation of the phototransduction cascade FERTILIZATION%REACTOME%R-RNO-1187000.1 Fertilization SIGNAL AMPLIFICATION%REACTOME%R-RNO-392518.1 Signal amplification ACTIVATED PKN1 STIMULATES TRANSCRIPTION OF AR (ANDROGEN RECEPTOR) REGULATED GENES KLK2 AND KLK3%REACTOME DATABASE ID RELEASE 66%10146086 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE%REACTOME%R-RNO-174414.1 Processive synthesis on the C-strand of the telomere IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 66%10145133 Immune System PORPHYRIN METABOLISM%REACTOME DATABASE ID RELEASE 66%10145085 Porphyrin metabolism RA BIOSYNTHESIS PATHWAY%REACTOME%R-RNO-5365859.1 RA biosynthesis pathway CLASSICAL KIR CHANNELS%REACTOME DATABASE ID RELEASE 66%10145835 Classical Kir channels REGULATION BY C-FLIP%REACTOME DATABASE ID RELEASE 66%10146009 Regulation by c-FLIP PROTEIN UBIQUITINATION%REACTOME DATABASE ID RELEASE 66%10146215 Protein ubiquitination THROMBOXANE SIGNALLING THROUGH TP RECEPTOR%REACTOME%R-RNO-428930.1 Thromboxane signalling through TP receptor APC C:CDC20 MEDIATED DEGRADATION OF SECURIN%REACTOME%R-RNO-174154.1 APC C:Cdc20 mediated degradation of Securin SHC1 EVENTS IN EGFR SIGNALING%REACTOME%R-RNO-180336.1 SHC1 events in EGFR signaling CHYLOMICRON REMODELING%REACTOME DATABASE ID RELEASE 66%10145241 Chylomicron remodeling PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA%REACTOME%R-RNO-72203.1 Processing of Capped Intron-Containing Pre-mRNA INSULIN RECEPTOR RECYCLING%REACTOME%R-RNO-77387.1 Insulin receptor recycling INTERLEUKIN-6 SIGNALING%REACTOME DATABASE ID RELEASE 66%10145796 Interleukin-6 signaling ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%R-RNO-111447.1 Activation of BAD and translocation to mitochondria C-SRC MEDIATED REGULATION OF CX43 FUNCTION AND CLOSURE OF GAP JUNCTIONS%REACTOME%R-RNO-191647.1 c-src mediated regulation of Cx43 function and closure of gap junctions EUKARYOTIC TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 66%10144835 Eukaryotic Translation Initiation TIE2 SIGNALING%REACTOME%R-RNO-210993.1 Tie2 Signaling SMALL INTERFERING RNA (SIRNA) BIOGENESIS%REACTOME%R-RNO-426486.1 Small interfering RNA (siRNA) biogenesis ARACHIDONATE PRODUCTION FROM DAG%REACTOME%R-RNO-426048.1 Arachidonate production from DAG NUCLEOTIDE EXCISION REPAIR%REACTOME%R-RNO-5696398.1 Nucleotide Excision Repair CAP-DEPENDENT TRANSLATION INITIATION%REACTOME%R-RNO-72737.1 Cap-dependent Translation Initiation TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE%REACTOME%R-RNO-168188.1 Toll Like Receptor TLR6:TLR2 Cascade CARBOHYDRATE METABOLISM%REACTOME DATABASE ID RELEASE 66%10144766 Carbohydrate metabolism ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS%REACTOME%R-RNO-176187.1 Activation of ATR in response to replication stress EXTRACELLULAR MATRIX ORGANIZATION%REACTOME DATABASE ID RELEASE 66%10145031 Extracellular matrix organization LEADING STRAND SYNTHESIS%REACTOME%R-RNO-69109.1 Leading Strand Synthesis REGULATED PROTEOLYSIS OF P75NTR%REACTOME DATABASE ID RELEASE 66%10145335 Regulated proteolysis of p75NTR MISMATCH REPAIR (MMR) DIRECTED BY MSH2:MSH3 (MUTSBETA)%REACTOME%R-RNO-5358606.1 Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) NEUTROPHIL DEGRANULATION%REACTOME%R-RNO-6798695.1 Neutrophil degranulation REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA%REACTOME DATABASE ID RELEASE 66%10145918 Regulation of innate immune responses to cytosolic DNA RHO GTPASES ACTIVATE CIT%REACTOME DATABASE ID RELEASE 66%10146123 RHO GTPases activate CIT FORMATION OF INCISION COMPLEX IN GG-NER%REACTOME%R-RNO-5696395.1 Formation of Incision Complex in GG-NER NTF3 ACTIVATES NTRK3 SIGNALING%REACTOME%R-RNO-9034013.1 NTF3 activates NTRK3 signaling REMOVAL OF THE FLAP INTERMEDIATE%REACTOME DATABASE ID RELEASE 66%10144734 Removal of the Flap Intermediate THE PROTON BUFFERING MODEL%REACTOME%R-RNO-167827.1 The proton buffering model POTASSIUM TRANSPORT CHANNELS%REACTOME%R-RNO-1296067.1 Potassium transport channels RUNX2 REGULATES OSTEOBLAST DIFFERENTIATION%REACTOME%R-RNO-8940973.1 RUNX2 regulates osteoblast differentiation BUTYRATE RESPONSE FACTOR 1 (BRF1) BINDS AND DESTABILIZES MRNA%REACTOME%R-RNO-450385.1 Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA NEUROTRANSMITTER CLEARANCE%REACTOME%R-RNO-112311.1 Neurotransmitter clearance RUNX3 REGULATES YAP1-MEDIATED TRANSCRIPTION%REACTOME DATABASE ID RELEASE 66%10146278 RUNX3 regulates YAP1-mediated transcription ESTABLISHMENT OF SISTER CHROMATID COHESION%REACTOME DATABASE ID RELEASE 66%10145970 Establishment of Sister Chromatid Cohesion PRC2 METHYLATES HISTONES AND DNA%REACTOME%R-RNO-212300.1 PRC2 methylates histones and DNA FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION%REACTOME%R-RNO-434316.1 Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION%REACTOME%R-RNO-381340.1 Transcriptional regulation of white adipocyte differentiation INTERLEUKIN-20 FAMILY SIGNALING%REACTOME%R-RNO-8854691.1 Interleukin-20 family signaling RHO GTPASE EFFECTORS%REACTOME DATABASE ID RELEASE 66%10144888 RHO GTPase Effectors HDL CLEARANCE%REACTOME%R-RNO-8964011.1 HDL clearance BIOSYNTHESIS OF DHA-DERIVED SPMS%REACTOME DATABASE ID RELEASE 66%10146302 Biosynthesis of DHA-derived SPMs IRS-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%R-RNO-2428928.1 IRS-related events triggered by IGF1R INSULIN RECEPTOR SIGNALLING CASCADE%REACTOME DATABASE ID RELEASE 66%10144875 Insulin receptor signalling cascade P2Y RECEPTORS%REACTOME%R-RNO-417957.1 P2Y receptors REGULATION OF ORNITHINE DECARBOXYLASE (ODC)%REACTOME DATABASE ID RELEASE 66%10145465 Regulation of ornithine decarboxylase (ODC) TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS%REACTOME%R-RNO-174417.1 Telomere C-strand (Lagging Strand) Synthesis PROTON-COUPLED MONOCARBOXYLATE TRANSPORT%REACTOME DATABASE ID RELEASE 66%10145649 Proton-coupled monocarboxylate transport INSULIN EFFECTS INCREASED SYNTHESIS OF XYLULOSE-5-PHOSPHATE%REACTOME%R-RNO-163754.1 Insulin effects increased synthesis of Xylulose-5-Phosphate TRANSPORT OF NUCLEOSIDES AND FREE PURINE AND PYRIMIDINE BASES ACROSS THE PLASMA MEMBRANE%REACTOME%R-RNO-83936.1 Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane METHYLATION%REACTOME DATABASE ID RELEASE 66%10144922 Methylation GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION%REACTOME%R-RNO-381676.1 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion CHYLOMICRON ASSEMBLY%REACTOME DATABASE ID RELEASE 66%10145238 Chylomicron assembly MYD88-INDEPENDENT TLR4 CASCADE%REACTOME%R-RNO-166166.1 MyD88-independent TLR4 cascade HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145724 Highly calcium permeable postsynaptic nicotinic acetylcholine receptors G ALPHA (12 13) SIGNALLING EVENTS%REACTOME%R-RNO-416482.1 G alpha (12 13) signalling events EPHRIN SIGNALING%REACTOME%R-RNO-3928664.1 Ephrin signaling METABOLISM OF NITRIC OXIDE%REACTOME DATABASE ID RELEASE 66%10145396 Metabolism of nitric oxide SUMOYLATION OF UBIQUITINYLATION PROTEINS%REACTOME%R-RNO-3232142.1 SUMOylation of ubiquitinylation proteins SIGNALING BY TGF-BETA RECEPTOR COMPLEX%REACTOME%R-RNO-170834.1 Signaling by TGF-beta Receptor Complex SIGNALING BY HEDGEHOG%REACTOME%R-RNO-5358351.1 Signaling by Hedgehog GABA A (RHO) RECEPTOR ACTIVATION%REACTOME DATABASE ID RELEASE 66%10145776 GABA A (rho) receptor activation SYNTHESIS OF PIPS IN THE NUCLEUS%REACTOME%R-RNO-8847453.1 Synthesis of PIPs in the nucleus TP53 REGULATES METABOLIC GENES%REACTOME DATABASE ID RELEASE 66%10144779 TP53 Regulates Metabolic Genes VLDL ASSEMBLY%REACTOME%R-RNO-8866423.1 VLDL assembly GLYCOSPHINGOLIPID METABOLISM%REACTOME%R-RNO-1660662.1 Glycosphingolipid metabolism PCP CE PATHWAY%REACTOME%R-RNO-4086400.1 PCP CE pathway OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA%REACTOME%R-RNO-1234176.1 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha OREXIN AND NEUROPEPTIDES FF AND QRFP BIND TO THEIR RESPECTIVE RECEPTORS%REACTOME%R-RNO-389397.1 Orexin and neuropeptides FF and QRFP bind to their respective receptors REGULATION OF TP53 EXPRESSION AND DEGRADATION%REACTOME%R-RNO-6806003.1 Regulation of TP53 Expression and Degradation METABOLISM OF SEROTONIN%REACTOME%R-RNO-380612.1 Metabolism of serotonin ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION%REACTOME DATABASE ID RELEASE 66%10145589 Adrenaline,noradrenaline inhibits insulin secretion DECTIN-1 MEDIATED NONCANONICAL NF-KB SIGNALING%REACTOME%R-RNO-5607761.1 Dectin-1 mediated noncanonical NF-kB signaling NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME DATABASE ID RELEASE 66%10145920 NOTCH2 Activation and Transmission of Signal to the Nucleus ESTROGEN-DEPENDENT GENE EXPRESSION%REACTOME%R-RNO-9018519.1 Estrogen-dependent gene expression TRIGLYCERIDE METABOLISM%REACTOME%R-RNO-8979227.1 Triglyceride metabolism P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME%R-RNO-372708.1 p130Cas linkage to MAPK signaling for integrins PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145719 Presynaptic nicotinic acetylcholine receptors PRE-MRNA SPLICING%REACTOME DATABASE ID RELEASE 66%10144828 pre-mRNA splicing BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS%REACTOME DATABASE ID RELEASE 66%10145554 Beta-oxidation of very long chain fatty acids PKMTS METHYLATE HISTONE LYSINES%REACTOME DATABASE ID RELEASE 66%10146041 PKMTs methylate histone lysines CHROMATIN MODIFYING ENZYMES%REACTOME%R-RNO-3247509.1 Chromatin modifying enzymes LGI-ADAM INTERACTIONS%REACTOME%R-RNO-5682910.1 LGI-ADAM interactions TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION%REACTOME DATABASE ID RELEASE 66%10145151 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7 8 or 9 activation METHIONINE SALVAGE PATHWAY%REACTOME DATABASE ID RELEASE 66%10145821 Methionine salvage pathway METABOLISM OF LIPIDS%REACTOME%R-RNO-556833.1 Metabolism of lipids INWARDLY RECTIFYING K+ CHANNELS%REACTOME DATABASE ID RELEASE 66%10145793 Inwardly rectifying K+ channels TFAP2 (AP-2) FAMILY REGULATES TRANSCRIPTION OF GROWTH FACTORS AND THEIR RECEPTORS%REACTOME%R-RNO-8866910.1 TFAP2 (AP-2) family regulates transcription of growth factors and their receptors SIGNALING BY ROBO RECEPTORS%REACTOME%R-RNO-376176.1 Signaling by ROBO receptors ORGANIC ANION TRANSPORTERS%REACTOME DATABASE ID RELEASE 66%10145484 Organic anion transporters AXONAL GROWTH INHIBITION (RHOA ACTIVATION)%REACTOME%R-RNO-193634.1 Axonal growth inhibition (RHOA activation) DOWNREGULATION OF ERBB2 SIGNALING%REACTOME%R-RNO-8863795.1 Downregulation of ERBB2 signaling ROS, RNS PRODUCTION IN PHAGOCYTES%REACTOME DATABASE ID RELEASE 66%10145602 ROS, RNS production in phagocytes GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME%R-RNO-354194.1 GRB2:SOS provides linkage to MAPK signaling for Integrins AMPLIFICATION OF SIGNAL FROM UNATTACHED KINETOCHORES VIA A MAD2 INHIBITORY SIGNAL%REACTOME DATABASE ID RELEASE 66%10145062 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal GDP-FUCOSE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 66%10145727 GDP-fucose biosynthesis REGULATION OF SIGNALING BY CBL%REACTOME%R-RNO-912631.1 Regulation of signaling by CBL CALNEXIN CALRETICULIN CYCLE%REACTOME DATABASE ID RELEASE 66%10145711 Calnexin calreticulin cycle COLLAGEN CHAIN TRIMERIZATION%REACTOME DATABASE ID RELEASE 66%10145922 Collagen chain trimerization SHC-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%R-RNO-2428933.1 SHC-related events triggered by IGF1R RAS ACTIVATION UPON CA2+ INFLUX THROUGH NMDA RECEPTOR%REACTOME%R-RNO-442982.1 Ras activation upon Ca2+ influx through NMDA receptor FRS-MEDIATED FGFR1 SIGNALING%REACTOME DATABASE ID RELEASE 66%10146102 FRS-mediated FGFR1 signaling MASTL FACILITATES MITOTIC PROGRESSION%REACTOME%R-RNO-2465910.1 MASTL Facilitates Mitotic Progression SYNTHESIS OF PE%REACTOME%R-RNO-1483213.1 Synthesis of PE INOSITOL TRANSPORTERS%REACTOME DATABASE ID RELEASE 66%10145635 Inositol transporters PHOSPHOLIPID METABOLISM%REACTOME%R-RNO-1483257.1 Phospholipid metabolism BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN%REACTOME%R-RNO-446193.1 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein BBSOME-MEDIATED CARGO-TARGETING TO CILIUM%REACTOME DATABASE ID RELEASE 66%10146078 BBSome-mediated cargo-targeting to cilium ACYL CHAIN REMODELLING OF PE%REACTOME%R-RNO-1482839.1 Acyl chain remodelling of PE RESOLUTION OF ABASIC SITES (AP SITES)%REACTOME%R-RNO-73933.1 Resolution of Abasic Sites (AP sites) ACTIVATION OF AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145580 Activation of AMPA receptors ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS%REACTOME%R-RNO-2122948.1 Activated NOTCH1 Transmits Signal to the Nucleus SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX)%REACTOME DATABASE ID RELEASE 66%10145441 Synthesis of Leukotrienes (LT) and Eoxins (EX) METABOLISM OF VITAMIN K%REACTOME%R-RNO-6806664.1 Metabolism of vitamin K OVARIAN TUMOR DOMAIN PROTEASES%REACTOME%R-RNO-5689896.1 Ovarian tumor domain proteases TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G2 CELL CYCLE ARREST%REACTOME DATABASE ID RELEASE 66%10146160 TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest EPHB-MEDIATED FORWARD SIGNALING%REACTOME DATABASE ID RELEASE 66%10146024 EPHB-mediated forward signaling APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS%REACTOME DATABASE ID RELEASE 66%10145068 APC C-mediated degradation of cell cycle proteins THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT%REACTOME DATABASE ID RELEASE 66%10144783 The citric acid (TCA) cycle and respiratory electron transport BIOTIN TRANSPORT AND METABOLISM%REACTOME DATABASE ID RELEASE 66%10145370 Biotin transport and metabolism SHC-MEDIATED CASCADE:FGFR1%REACTOME DATABASE ID RELEASE 66%10146109 SHC-mediated cascade:FGFR1 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE%REACTOME%R-RNO-77075.1 RNA Pol II CTD phosphorylation and interaction with CE AMINO ACID CONJUGATION%REACTOME DATABASE ID RELEASE 66%10145091 Amino Acid conjugation ALPHA-LINOLENIC ACID (ALA) METABOLISM%REACTOME%R-RNO-2046106.1 alpha-linolenic acid (ALA) metabolism THE PHOTOTRANSDUCTION CASCADE%REACTOME DATABASE ID RELEASE 66%10144866 The phototransduction cascade MITOCHONDRIAL FATTY ACID BETA-OXIDATION%REACTOME%R-RNO-77289.1 Mitochondrial Fatty Acid Beta-Oxidation SULFUR AMINO ACID METABOLISM%REACTOME%R-RNO-1614635.1 Sulfur amino acid metabolism NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 66%10145481 Norepinephrine Neurotransmitter Release Cycle BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145954 Binding and Uptake of Ligands by Scavenger Receptors FCERI MEDIATED CA+2 MOBILIZATION%REACTOME%R-RNO-2871809.1 FCERI mediated Ca+2 mobilization BIOSYNTHESIS OF ELECTROPHILIC Ω-3 PUFA OXO-DERIVATIVES%REACTOME DATABASE ID RELEASE 66%10146319 Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives PTEN REGULATION%REACTOME%R-RNO-6807070.1 PTEN Regulation TFAP2A ACTS AS A TRANSCRIPTIONAL REPRESSOR DURING RETINOIC ACID INDUCED CELL DIFFERENTIATION%REACTOME%R-RNO-8869496.1 TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1)%REACTOME DATABASE ID RELEASE 66%10145538 Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) TOLL LIKE RECEPTOR 4 (TLR4) CASCADE%REACTOME DATABASE ID RELEASE 66%10145130 Toll Like Receptor 4 (TLR4) Cascade ADENYLATE CYCLASE ACTIVATING PATHWAY%REACTOME DATABASE ID RELEASE 66%10145191 Adenylate cyclase activating pathway SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL%REACTOME DATABASE ID RELEASE 66%10145908 Synthesis of pyrophosphates in the cytosol NEGATIVE REGULATION OF ACTIVITY OF TFAP2 (AP-2) FAMILY TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 66%10146003 Negative regulation of activity of TFAP2 (AP-2) family transcription factors VLDL CLEARANCE%REACTOME DATABASE ID RELEASE 66%10146224 VLDL clearance RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF HSCS%REACTOME DATABASE ID RELEASE 66%10146239 RUNX1 regulates transcription of genes involved in differentiation of HSCs BIOSYNTHESIS OF DPAN-6 SPMS%REACTOME DATABASE ID RELEASE 66%10146307 Biosynthesis of DPAn-6 SPMs GROWTH HORMONE RECEPTOR SIGNALING%REACTOME DATABASE ID RELEASE 66%10145708 Growth hormone receptor signaling REUPTAKE OF GABA%REACTOME%R-RNO-888593.1 Reuptake of GABA THYROXINE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 66%10145424 Thyroxine biosynthesis PLATELET ADHESION TO EXPOSED COLLAGEN%REACTOME%R-RNO-75892.1 Platelet Adhesion to exposed collagen INITIAL TRIGGERING OF COMPLEMENT%REACTOME%R-RNO-166663.1 Initial triggering of complement FORMATION OF THE CORNIFIED ENVELOPE%REACTOME%R-RNO-6809371.1 Formation of the cornified envelope SIGNALING BY MET%REACTOME%R-RNO-6806834.1 Signaling by MET RHO GTPASES ACTIVATE FORMINS%REACTOME%R-RNO-5663220.1 RHO GTPases Activate Formins CITRIC ACID CYCLE (TCA CYCLE)%REACTOME%R-RNO-71403.1 Citric acid cycle (TCA cycle) CHAPERONIN-MEDIATED PROTEIN FOLDING%REACTOME%R-RNO-390466.1 Chaperonin-mediated protein folding KINESINS%REACTOME%R-RNO-983189.1 Kinesins SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL%REACTOME DATABASE ID RELEASE 66%10145904 Synthesis of IP3 and IP4 in the cytosol CARGO RECOGNITION FOR CLATHRIN-MEDIATED ENDOCYTOSIS%REACTOME%R-RNO-8856825.1 Cargo recognition for clathrin-mediated endocytosis ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR%REACTOME DATABASE ID RELEASE 66%10145698 Activation of Ca-permeable Kainate Receptor SIGNALING BY RHO GTPASES%REACTOME DATABASE ID RELEASE 66%10144889 Signaling by Rho GTPases OLIGOMERIZATION OF CONNEXINS INTO CONNEXONS%REACTOME DATABASE ID RELEASE 66%10145304 Oligomerization of connexins into connexons CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKK%REACTOME%R-RNO-442717.1 CREB phosphorylation through the activation of CaMKK PEPTIDE CHAIN ELONGATION%REACTOME%R-RNO-156902.1 Peptide chain elongation CLASS B 2 (SECRETIN FAMILY RECEPTORS)%REACTOME%R-RNO-373080.1 Class B 2 (Secretin family receptors) ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME DATABASE ID RELEASE 66%10145219 Activation of APC C and APC C:Cdc20 mediated degradation of mitotic proteins IRE1ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 66%10145532 IRE1alpha activates chaperones RHESUS GLYCOPROTEINS MEDIATE AMMONIUM TRANSPORT.%REACTOME DATABASE ID RELEASE 66%10145662 Rhesus glycoproteins mediate ammonium transport. RNA POLYMERASE I TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 66%10144885 RNA Polymerase I Transcription Termination APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B%REACTOME%R-RNO-174048.1 APC C:Cdc20 mediated degradation of Cyclin B MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME%REACTOME%R-RNO-975155.1 MyD88 dependent cascade initiated on endosome DSCAM INTERACTIONS%REACTOME%R-RNO-376172.1 DSCAM interactions MISCELLANEOUS TRANSPORT AND BINDING EVENTS%REACTOME%R-RNO-5223345.1 Miscellaneous transport and binding events MITOCHONDRIAL TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 66%10145117 Mitochondrial transcription initiation PINK PARKIN MEDIATED MITOPHAGY%REACTOME DATABASE ID RELEASE 66%10146045 Pink Parkin Mediated Mitophagy SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R)%REACTOME%R-RNO-2404192.1 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) INTERCONVERSION OF POLYAMINES%REACTOME DATABASE ID RELEASE 66%10145061 Interconversion of polyamines NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%R-RNO-2122947.1 NOTCH1 Intracellular Domain Regulates Transcription ELECTRIC TRANSMISSION ACROSS GAP JUNCTIONS%REACTOME DATABASE ID RELEASE 66%10145507 Electric Transmission Across Gap Junctions THE NLRP3 INFLAMMASOME%REACTOME%R-RNO-844456.1 The NLRP3 inflammasome FCGR ACTIVATION%REACTOME DATABASE ID RELEASE 66%10145910 FCGR activation SLIT2:ROBO1 INCREASES RHOA ACTIVITY%REACTOME DATABASE ID RELEASE 66%10146285 SLIT2:ROBO1 increases RHOA activity TICAM1-DEPENDENT ACTIVATION OF IRF3 IRF7%REACTOME DATABASE ID RELEASE 66%10145179 TICAM1-dependent activation of IRF3 IRF7 COX REACTIONS%REACTOME DATABASE ID RELEASE 66%10145051 COX reactions SIGNALING BY VEGF%REACTOME DATABASE ID RELEASE 66%10145273 Signaling by VEGF REGULATION OF MECP2 EXPRESSION AND ACTIVITY%REACTOME%R-RNO-9022692.1 Regulation of MECP2 expression and activity ACTIVATION OF TRKA RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145141 Activation of TRKA receptors DOWNSTREAM SIGNALING OF ACTIVATED FGFR2%REACTOME DATABASE ID RELEASE 66%10145255 Downstream signaling of activated FGFR2 VASOPRESSIN-LIKE RECEPTORS%REACTOME%R-RNO-388479.1 Vasopressin-like receptors ANCHORING OF THE BASAL BODY TO THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 66%10146081 Anchoring of the basal body to the plasma membrane ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION%REACTOME%R-RNO-2730905.1 Role of LAT2 NTAL LAB on calcium mobilization NEPHRIN FAMILY INTERACTIONS%REACTOME%R-RNO-373753.1 Nephrin family interactions IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX%REACTOME%R-RNO-937042.1 IRAK2 mediated activation of TAK1 complex PYRIMIDINE SALVAGE%REACTOME DATABASE ID RELEASE 66%10144845 Pyrimidine salvage TWIK-RELATED ALKALINE PH ACTIVATED K+ CHANNEL (TALK)%REACTOME DATABASE ID RELEASE 66%10145847 TWIK-related alkaline pH activated K+ channel (TALK) THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS)%REACTOME%R-RNO-456926.1 Thrombin signalling through proteinase activated receptors (PARs) DEADENYLATION OF MRNA%REACTOME DATABASE ID RELEASE 66%10145638 Deadenylation of mRNA FORMYL PEPTIDE RECEPTORS BIND FORMYL PEPTIDES AND MANY OTHER LIGANDS%REACTOME DATABASE ID RELEASE 66%10145663 Formyl peptide receptors bind formyl peptides and many other ligands ACTIVATION AND OLIGOMERIZATION OF BAK PROTEIN%REACTOME DATABASE ID RELEASE 66%10145015 Activation and oligomerization of BAK protein A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS%REACTOME%R-RNO-1971475.1 A tetrasaccharide linker sequence is required for GAG synthesis PKA ACTIVATION IN GLUCAGON SIGNALLING%REACTOME%R-RNO-164378.1 PKA activation in glucagon signalling CLASS C 3 (METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS)%REACTOME DATABASE ID RELEASE 66%10145488 Class C 3 (Metabotropic glutamate pheromone receptors) CA-DEPENDENT EVENTS%REACTOME DATABASE ID RELEASE 66%10144989 Ca-dependent events SUMOYLATION OF RNA BINDING PROTEINS%REACTOME DATABASE ID RELEASE 66%10146034 SUMOylation of RNA binding proteins VITAMIN B5 (PANTOTHENATE) METABOLISM%REACTOME%R-RNO-199220.1 Vitamin B5 (pantothenate) metabolism ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING%REACTOME%R-RNO-451326.1 Activation of kainate receptors upon glutamate binding TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS%REACTOME DATABASE ID RELEASE 66%10145878 Transcriptional activation of mitochondrial biogenesis DOWNSTREAM SIGNALING OF ACTIVATED FGFR1%REACTOME%R-RNO-5654687.1 Downstream signaling of activated FGFR1 TRP CHANNELS%REACTOME%R-RNO-3295583.1 TRP channels SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION%REACTOME%R-RNO-2173796.1 SMAD2 SMAD3:SMAD4 heterotrimer regulates transcription DARPP-32 EVENTS%REACTOME DATABASE ID RELEASE 66%10145005 DARPP-32 events ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON%REACTOME DATABASE ID RELEASE 66%10145137 Activation of IRF3 IRF7 mediated by TBK1 IKK epsilon GLUCAGON-TYPE LIGAND RECEPTORS%REACTOME%R-RNO-420092.1 Glucagon-type ligand receptors SUMO E3 LIGASES SUMOYLATE TARGET PROTEINS%REACTOME DATABASE ID RELEASE 66%10145992 SUMO E3 ligases SUMOylate target proteins AXON GUIDANCE%REACTOME%R-RNO-422475.1 Axon guidance SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE%REACTOME%R-RNO-416572.1 Sema4D induced cell migration and growth-cone collapse FREE FATTY ACIDS REGULATE INSULIN SECRETION%REACTOME DATABASE ID RELEASE 66%10145587 Free fatty acids regulate insulin secretion SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN%REACTOME DATABASE ID RELEASE 66%10145615 Synthesis, secretion, and deacylation of Ghrelin SIGNALING BY NOTCH3%REACTOME DATABASE ID RELEASE 66%10145952 Signaling by NOTCH3 OXYGEN-DEPENDENT ASPARAGINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA%REACTOME DATABASE ID RELEASE 66%10145810 Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha REPRODUCTION%REACTOME%R-RNO-1474165.1 Reproduction PHOSPHOLIPASE C-MEDIATED CASCADE: FGFR1%REACTOME%R-RNO-5654219.1 Phospholipase C-mediated cascade: FGFR1 MELANIN BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 66%10146119 Melanin biosynthesis DIGESTION AND ABSORPTION%REACTOME%R-RNO-8963743.1 Digestion and absorption GAP JUNCTION DEGRADATION%REACTOME DATABASE ID RELEASE 66%10145296 Gap junction degradation O-LINKED GLYCOSYLATION OF MUCINS%REACTOME%R-RNO-913709.1 O-linked glycosylation of mucins CTLA4 INHIBITORY SIGNALING%REACTOME DATABASE ID RELEASE 66%10145541 CTLA4 inhibitory signaling PENTOSE PHOSPHATE PATHWAY%REACTOME%R-RNO-71336.1 Pentose phosphate pathway UBIQUINOL BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 66%10145949 Ubiquinol biosynthesis PHASE I - FUNCTIONALIZATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 66%10144820 Phase I - Functionalization of compounds PRESYNAPTIC PHASE OF HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME DATABASE ID RELEASE 66%10146131 Presynaptic phase of homologous DNA pairing and strand exchange SLC-MEDIATED TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 66%10144952 SLC-mediated transmembrane transport ASYMMETRIC LOCALIZATION OF PCP PROTEINS%REACTOME%R-RNO-4608870.1 Asymmetric localization of PCP proteins ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12%REACTOME%R-RNO-392170.1 ADP signalling through P2Y purinoceptor 12 SIGNALING BY TGF-BETA FAMILY MEMBERS%REACTOME DATABASE ID RELEASE 66%10145195 Signaling by TGF-beta family members MITOTIC G2-G2 M PHASES%REACTOME DATABASE ID RELEASE 66%10145075 Mitotic G2-G2 M phases SIGNALLING TO ERK5%REACTOME DATABASE ID RELEASE 66%10145365 Signalling to ERK5 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS.%REACTOME%R-RNO-163200.1 Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. MYD88:MAL(TIRAP) CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME%R-RNO-166058.1 MyD88:MAL(TIRAP) cascade initiated on plasma membrane FORMATION OF THE ACTIVE COFACTOR, UDP-GLUCURONATE%REACTOME DATABASE ID RELEASE 66%10144771 Formation of the active cofactor, UDP-glucuronate GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK%REACTOME DATABASE ID RELEASE 66%10145366 Gastrin-CREB signalling pathway via PKC and MAPK INTRACELLULAR OXYGEN TRANSPORT%REACTOME%R-RNO-8981607.1 Intracellular oxygen transport NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS%REACTOME DATABASE ID RELEASE 66%10145178 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways VITAMINS B6 ACTIVATION TO PYRIDOXAL PHOSPHATE%REACTOME%R-RNO-964975.1 Vitamins B6 activation to pyridoxal phosphate SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION%REACTOME DATABASE ID RELEASE 66%10145592 Sema4D mediated inhibition of cell attachment and migration WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2%REACTOME%R-RNO-5140745.1 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME%R-RNO-110381.1 Resolution of AP sites via the single-nucleotide replacement pathway SCAVENGING BY CLASS B RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145958 Scavenging by Class B Receptors REGULATION OF TLR BY ENDOGENOUS LIGAND%REACTOME DATABASE ID RELEASE 66%10146066 Regulation of TLR by endogenous ligand NOTCH-HLH TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 66%10145446 Notch-HLH transcription pathway VITAMINS%REACTOME%R-RNO-211916.1 Vitamins UCH PROTEINASES%REACTOME DATABASE ID RELEASE 66%10146120 UCH proteinases ADRENOCEPTORS%REACTOME%R-RNO-390696.1 Adrenoceptors REGULATION OF TP53 EXPRESSION%REACTOME DATABASE ID RELEASE 66%10146179 Regulation of TP53 Expression POST-TRANSLATIONAL PROTEIN MODIFICATION%REACTOME%R-RNO-597592.1 Post-translational protein modification FGFR1B LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 66%10145285 FGFR1b ligand binding and activation HOMOLOGY DIRECTED REPAIR%REACTOME DATABASE ID RELEASE 66%10144914 Homology Directed Repair TRANSCRIPTION-COUPLED NUCLEOTIDE EXCISION REPAIR (TC-NER)%REACTOME%R-RNO-6781827.1 Transcription-Coupled Nucleotide Excision Repair (TC-NER) TRANSCRIPTIONAL REGULATION BY RUNX2%REACTOME DATABASE ID RELEASE 66%10146258 Transcriptional regulation by RUNX2 PRE-NOTCH PROCESSING IN GOLGI%REACTOME%R-RNO-1912420.1 Pre-NOTCH Processing in Golgi CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA%REACTOME DATABASE ID RELEASE 66%10145175 Cytosolic sensors of pathogen-associated DNA HDL ASSEMBLY%REACTOME DATABASE ID RELEASE 66%10145449 HDL assembly ERYTHROCYTES TAKE UP OXYGEN AND RELEASE CARBON DIOXIDE%REACTOME DATABASE ID RELEASE 66%10145820 Erythrocytes take up oxygen and release carbon dioxide REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN%REACTOME%R-RNO-1234174.1 Regulation of Hypoxia-inducible Factor (HIF) by oxygen PHASE 2 - PLATEAU PHASE%REACTOME%R-RNO-5576893.1 Phase 2 - plateau phase GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER%REACTOME%R-RNO-6782210.1 Gap-filling DNA repair synthesis and ligation in TC-NER RHO GTPASE CYCLE%REACTOME DATABASE ID RELEASE 66%10145340 Rho GTPase cycle GLUTATHIONE CONJUGATION%REACTOME%R-RNO-156590.1 Glutathione conjugation PTK6 DOWN-REGULATION%REACTOME DATABASE ID RELEASE 66%10146208 PTK6 Down-Regulation TP53 REGULATES TRANSCRIPTION OF SEVERAL ADDITIONAL CELL DEATH GENES WHOSE SPECIFIC ROLES IN P53-DEPENDENT APOPTOSIS REMAIN UNCERTAIN%REACTOME DATABASE ID RELEASE 66%10146175 TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain CYCLIN A B1 B2 ASSOCIATED EVENTS DURING G2 M TRANSITION%REACTOME%R-RNO-69273.1 Cyclin A B1 B2 associated events during G2 M transition SPHINGOLIPID METABOLISM%REACTOME%R-RNO-428157.1 Sphingolipid metabolism SPERM:OOCYTE MEMBRANE BINDING%REACTOME DATABASE ID RELEASE 66%10145840 Sperm:Oocyte Membrane Binding CRISTAE FORMATION%REACTOME%R-RNO-8949613.1 Cristae formation AROMATIC AMINES CAN BE N-HYDROXYLATED OR N-DEALKYLATED BY CYP1A2%REACTOME%R-RNO-211957.1 Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 ABACAVIR TRANSPORT AND METABOLISM%REACTOME DATABASE ID RELEASE 66%10145942 Abacavir transport and metabolism REGULATION OF CYTOSKELETAL REMODELING AND CELL SPREADING BY IPP COMPLEX COMPONENTS%REACTOME DATABASE ID RELEASE 66%10145641 Regulation of cytoskeletal remodeling and cell spreading by IPP complex components PHOSPHOLIPASE C-MEDIATED CASCADE; FGFR3%REACTOME DATABASE ID RELEASE 66%10146099 Phospholipase C-mediated cascade; FGFR3 RAF MAP KINASE CASCADE%REACTOME%R-RNO-5673001.1 RAF MAP kinase cascade ABASIC SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 66%10144981 Abasic sugar-phosphate removal via the single-nucleotide replacement pathway CRMPS IN SEMA3A SIGNALING%REACTOME%R-RNO-399956.1 CRMPs in Sema3A signaling REGULATION OF TP53 ACTIVITY THROUGH ACETYLATION%REACTOME DATABASE ID RELEASE 66%10146001 Regulation of TP53 Activity through Acetylation BIOSYNTHESIS OF MARESINS%REACTOME%R-RNO-9018682.1 Biosynthesis of maresins TP53 REGULATES TRANSCRIPTION OF CELL CYCLE GENES%REACTOME%R-RNO-6791312.1 TP53 Regulates Transcription of Cell Cycle Genes PLC BETA MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 66%10144985 PLC beta mediated events REGULATION OF EXPRESSION OF SLITS AND ROBOS%REACTOME DATABASE ID RELEASE 66%10146286 Regulation of expression of SLITs and ROBOs GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION%REACTOME DATABASE ID RELEASE 66%10145475 GABA synthesis, release, reuptake and degradation INTEGRIN ALPHAIIB BETA3 SIGNALING%REACTOME DATABASE ID RELEASE 66%10145476 Integrin alphaIIb beta3 signaling FCERI MEDIATED MAPK ACTIVATION%REACTOME DATABASE ID RELEASE 66%10145166 FCERI mediated MAPK activation PTK6 ACTIVATES STAT3%REACTOME DATABASE ID RELEASE 66%10146200 PTK6 Activates STAT3 CLEC7A INFLAMMASOME PATHWAY%REACTOME%R-RNO-5660668.1 CLEC7A inflammasome pathway SIGNALING BY NTRK1 (TRKA)%REACTOME%R-RNO-187037.1 Signaling by NTRK1 (TRKA) PEPTIDE HORMONE METABOLISM%REACTOME%R-RNO-2980736.1 Peptide hormone metabolism CELL CYCLE%REACTOME DATABASE ID RELEASE 66%10144722 Cell Cycle TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G1 CELL CYCLE ARREST%REACTOME%R-RNO-6804116.1 TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest INTERLEUKIN-2 SIGNALING%REACTOME%R-RNO-9020558.1 Interleukin-2 signaling DEPURINATION%REACTOME DATABASE ID RELEASE 66%10144975 Depurination G2 M DNA REPLICATION CHECKPOINT%REACTOME%R-RNO-69478.1 G2 M DNA replication checkpoint FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX%REACTOME DATABASE ID RELEASE 66%10145392 Formation of the beta-catenin:TCF transactivating complex ACTIVATION OF THE TFAP2 (AP-2) FAMILY OF TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 66%10146233 Activation of the TFAP2 (AP-2) family of transcription factors ATF6 (ATF6-ALPHA) ACTIVATES CHAPERONES%REACTOME%R-RNO-381033.1 ATF6 (ATF6-alpha) activates chaperones SHC-MEDIATED CASCADE:FGFR2%REACTOME%R-RNO-5654699.1 SHC-mediated cascade:FGFR2 G1 PHASE%REACTOME%R-RNO-69236.1 G1 Phase SYNTHESIS OF CL%REACTOME DATABASE ID RELEASE 66%10145873 Synthesis of CL SIGNALING BY PDGF%REACTOME DATABASE ID RELEASE 66%10145268 Signaling by PDGF SIGNALING BY FGFR%REACTOME DATABASE ID RELEASE 66%10145253 Signaling by FGFR FRS-MEDIATED FGFR3 SIGNALING%REACTOME%R-RNO-5654706.1 FRS-mediated FGFR3 signaling ACTIVATION OF DNA FRAGMENTATION FACTOR%REACTOME DATABASE ID RELEASE 66%10145439 Activation of DNA fragmentation factor CASPASE ACTIVATION VIA EXTRINSIC APOPTOTIC SIGNALLING PATHWAY%REACTOME%R-RNO-5357769.1 Caspase activation via extrinsic apoptotic signalling pathway INTERLEUKIN-21 SIGNALING%REACTOME%R-RNO-9020958.1 Interleukin-21 signaling BETA-CATENIN INDEPENDENT WNT SIGNALING%REACTOME DATABASE ID RELEASE 66%10145579 Beta-catenin independent WNT signaling PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS%REACTOME%R-RNO-73817.1 Purine ribonucleoside monophosphate biosynthesis GRB7 EVENTS IN ERBB2 SIGNALING%REACTOME%R-RNO-1306955.1 GRB7 events in ERBB2 signaling DEFENSINS%REACTOME%R-RNO-1461973.1 Defensins RUNX2 REGULATES BONE DEVELOPMENT%REACTOME DATABASE ID RELEASE 66%10146257 RUNX2 regulates bone development PROPIONYL-COA CATABOLISM%REACTOME DATABASE ID RELEASE 66%10144800 Propionyl-CoA catabolism KANDUTSCH-RUSSELL PATHWAY%REACTOME DATABASE ID RELEASE 66%10146182 Kandutsch-Russell pathway COMPLEMENT CASCADE%REACTOME%R-RNO-166658.1 Complement cascade MYD88 CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 66%10145155 MyD88 cascade initiated on plasma membrane INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS%REACTOME%R-RNO-141405.1 Inhibition of the proteolytic activity of APC C required for the onset of anaphase by mitotic spindle checkpoint components INTESTINAL HEXOSE ABSORPTION%REACTOME%R-RNO-8981373.1 Intestinal hexose absorption DOPAMINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME%R-RNO-212676.1 Dopamine Neurotransmitter Release Cycle MET ACTIVATES RAS SIGNALING%REACTOME DATABASE ID RELEASE 66%10146212 MET activates RAS signaling DAP12 SIGNALING%REACTOME DATABASE ID RELEASE 66%10145432 DAP12 signaling GAB1 SIGNALOSOME%REACTOME DATABASE ID RELEASE 66%10145248 GAB1 signalosome RIPK1-MEDIATED REGULATED NECROSIS%REACTOME%R-RNO-5213460.1 RIPK1-mediated regulated necrosis REGULATION OF PTEN GENE TRANSCRIPTION%REACTOME%R-RNO-8943724.1 Regulation of PTEN gene transcription AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1%REACTOME DATABASE ID RELEASE 66%10145450 Autodegradation of the E3 ubiquitin ligase COP1 GENE EXPRESSION (TRANSCRIPTION)%REACTOME DATABASE ID RELEASE 66%10144751 Gene expression (Transcription) MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES%REACTOME%R-RNO-450282.1 MAPK targets Nuclear events mediated by MAP kinases RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER%REACTOME%R-RNO-76071.1 RNA Polymerase III Transcription Initiation From Type 3 Promoter HSF1-DEPENDENT TRANSACTIVATION%REACTOME%R-RNO-3371571.1 HSF1-dependent transactivation DOWNSTREAM TCR SIGNALING%REACTOME DATABASE ID RELEASE 66%10145375 Downstream TCR signaling P75NTR RECRUITS SIGNALLING COMPLEXES%REACTOME%R-RNO-209543.1 p75NTR recruits signalling complexes CHOLESTEROL BIOSYNTHESIS%REACTOME%R-RNO-191273.1 Cholesterol biosynthesis MEMBRANE TRAFFICKING%REACTOME DATABASE ID RELEASE 66%10145299 Membrane Trafficking HIGHLY CALCIUM PERMEABLE NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%R-RNO-629597.1 Highly calcium permeable nicotinic acetylcholine receptors PHASE 1 - INACTIVATION OF FAST NA+ CHANNELS%REACTOME DATABASE ID RELEASE 66%10146070 Phase 1 - inactivation of fast Na+ channels TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR%REACTOME DATABASE ID RELEASE 66%10145903 Trafficking and processing of endosomal TLR INTEGRATION OF ENERGY METABOLISM%REACTOME%R-RNO-163685.1 Integration of energy metabolism INTERLEUKIN-10 SIGNALING%REACTOME DATABASE ID RELEASE 66%10145687 Interleukin-10 signaling MITOTIC ANAPHASE%REACTOME DATABASE ID RELEASE 66%10145224 Mitotic Anaphase ZINC EFFLUX AND COMPARTMENTALIZATION BY THE SLC30 FAMILY%REACTOME DATABASE ID RELEASE 66%10145653 Zinc efflux and compartmentalization by the SLC30 family GABA A RECEPTOR ACTIVATION%REACTOME%R-RNO-977441.1 GABA A receptor activation INTESTINAL ABSORPTION%REACTOME DATABASE ID RELEASE 66%10145282 Intestinal absorption DEADENYLATION-DEPENDENT MRNA DECAY%REACTOME%R-RNO-429914.1 Deadenylation-dependent mRNA decay EPH-EPHRIN MEDIATED REPULSION OF CELLS%REACTOME%R-RNO-3928665.1 EPH-ephrin mediated repulsion of cells ADRENALINE SIGNALLING THROUGH ALPHA-2 ADRENERGIC RECEPTOR%REACTOME DATABASE ID RELEASE 66%10145560 Adrenaline signalling through Alpha-2 adrenergic receptor MINERALOCORTICOID BIOSYNTHESIS%REACTOME%R-RNO-193993.1 Mineralocorticoid biosynthesis BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 66%10144858 Base Excision Repair INTERLEUKIN-2 FAMILY SIGNALING%REACTOME DATABASE ID RELEASE 66%10145686 Interleukin-2 family signaling POST-TRANSLATIONAL PROTEIN PHOSPHORYLATION%REACTOME DATABASE ID RELEASE 66%10146280 Post-translational protein phosphorylation CELLULAR RESPONSES TO STRESS%REACTOME%R-RNO-2262752.1 Cellular responses to stress RECYCLING OF BILE ACIDS AND SALTS%REACTOME%R-RNO-159418.1 Recycling of bile acids and salts METAL ION SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 66%10145650 Metal ion SLC transporters UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D%REACTOME%R-RNO-75815.1 Ubiquitin-dependent degradation of Cyclin D SIGNALING BY FGFR4%REACTOME DATABASE ID RELEASE 66%10145262 Signaling by FGFR4 SODIUM CALCIUM EXCHANGERS%REACTOME DATABASE ID RELEASE 66%10145617 Sodium Calcium exchangers POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE%REACTOME%R-RNO-174411.1 Polymerase switching on the C-strand of the telomere INTERLEUKIN RECEPTOR SHC SIGNALING%REACTOME%R-RNO-912526.1 Interleukin receptor SHC signaling REGULATION OF KIT SIGNALING%REACTOME%R-RNO-1433559.1 Regulation of KIT signaling TRAF6 MEDIATED NF-KB ACTIVATION%REACTOME%R-RNO-933542.1 TRAF6 mediated NF-kB activation REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS%REACTOME%R-RNO-450531.1 Regulation of mRNA stability by proteins that bind AU-rich elements ANDROGEN BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 66%10145322 Androgen biosynthesis ACYL CHAIN REMODELLING OF PI%REACTOME%R-RNO-1482922.1 Acyl chain remodelling of PI GLUCURONIDATION%REACTOME%R-RNO-156588.1 Glucuronidation SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS%REACTOME%R-RNO-446219.1 Synthesis of substrates in N-glycan biosythesis FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION%REACTOME%R-RNO-983231.1 Factors involved in megakaryocyte development and platelet production MRNA SPLICING%REACTOME DATABASE ID RELEASE 66%10144829 mRNA Splicing FRUCTOSE CATABOLISM%REACTOME%R-RNO-70350.1 Fructose catabolism METABOLISM OF FAT-SOLUBLE VITAMINS%REACTOME DATABASE ID RELEASE 66%10145778 Metabolism of fat-soluble vitamins NGF PROCESSING%REACTOME DATABASE ID RELEASE 66%10145269 NGF processing BETA-CATENIN PHOSPHORYLATION CASCADE%REACTOME%R-RNO-196299.1 Beta-catenin phosphorylation cascade SYNDECAN INTERACTIONS%REACTOME%R-RNO-3000170.1 Syndecan interactions MET RECEPTOR RECYCLING%REACTOME DATABASE ID RELEASE 66%10146253 MET receptor recycling IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX%REACTOME DATABASE ID RELEASE 66%10144904 Import of palmitoyl-CoA into the mitochondrial matrix COSTIMULATION BY THE CD28 FAMILY%REACTOME DATABASE ID RELEASE 66%10145355 Costimulation by the CD28 family G1 S TRANSITION%REACTOME DATABASE ID RELEASE 66%10144724 G1 S Transition PHOSPHO-PLA2 PATHWAY%REACTOME DATABASE ID RELEASE 66%10144988 phospho-PLA2 pathway NRAGE SIGNALS DEATH THROUGH JNK%REACTOME%R-RNO-193648.1 NRAGE signals death through JNK HDR THROUGH HOMOLOGOUS RECOMBINATION (HRR)%REACTOME%R-RNO-5685942.1 HDR through Homologous Recombination (HRR) N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE%REACTOME%R-RNO-532668.1 N-glycan trimming in the ER and Calnexin Calreticulin cycle IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL%REACTOME%R-RNO-198933.1 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell GAMMA-CARBOXYLATION, TRANSPORT, AND AMINO-TERMINAL CLEAVAGE OF PROTEINS%REACTOME DATABASE ID RELEASE 66%10145094 Gamma-carboxylation, transport, and amino-terminal cleavage of proteins NOTCH4 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME DATABASE ID RELEASE 66%10146329 NOTCH4 Activation and Transmission of Signal to the Nucleus PHOSPHATE BOND HYDROLYSIS BY NUDT PROTEINS%REACTOME DATABASE ID RELEASE 66%10145964 Phosphate bond hydrolysis by NUDT proteins NON-INTEGRIN MEMBRANE-ECM INTERACTIONS%REACTOME DATABASE ID RELEASE 66%10145963 Non-integrin membrane-ECM interactions MITOTIC METAPHASE ANAPHASE TRANSITION%REACTOME DATABASE ID RELEASE 66%10145108 Mitotic Metaphase Anaphase Transition CILIUM ASSEMBLY%REACTOME DATABASE ID RELEASE 66%10146080 Cilium Assembly BETA OXIDATION OF MYRISTOYL-COA TO LAUROYL-COA%REACTOME%R-RNO-77285.1 Beta oxidation of myristoyl-CoA to lauroyl-CoA CELLULAR HEXOSE TRANSPORT%REACTOME%R-RNO-189200.1 Cellular hexose transport CARGO CONCENTRATION IN THE ER%REACTOME DATABASE ID RELEASE 66%10146150 Cargo concentration in the ER BIOSYNTHESIS OF SPECIALIZED PRORESOLVING MEDIATORS (SPMS)%REACTOME%R-RNO-9018678.1 Biosynthesis of specialized proresolving mediators (SPMs) DOWNSTREAM SIGNALING OF ACTIVATED FGFR3%REACTOME%R-RNO-5654708.1 Downstream signaling of activated FGFR3 BIOSYNTHESIS OF DHA-DERIVED SULFIDO CONJUGATES%REACTOME%R-RNO-9026395.1 Biosynthesis of DHA-derived sulfido conjugates LOCALIZATION OF THE PINCH-ILK-PARVIN COMPLEX TO FOCAL ADHESIONS%REACTOME%R-RNO-446343.1 Localization of the PINCH-ILK-PARVIN complex to focal adhesions ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT)%REACTOME%R-RNO-917729.1 Endosomal Sorting Complex Required For Transport (ESCRT) MAPK3 (ERK1) ACTIVATION%REACTOME%R-RNO-110056.1 MAPK3 (ERK1) activation PEPTIDE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145486 Peptide ligand-binding receptors BIOSYNTHESIS OF EPA-DERIVED SPMS%REACTOME%R-RNO-9018679.1 Biosynthesis of EPA-derived SPMs HORMONE LIGAND-BINDING RECEPTORS%REACTOME%R-RNO-375281.1 Hormone ligand-binding receptors BIOSYNTHESIS OF DPA-DERIVED SPMS%REACTOME%R-RNO-9018683.1 Biosynthesis of DPA-derived SPMs SIGNALING BY PTK6%REACTOME%R-RNO-8848021.1 Signaling by PTK6 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%R-RNO-975144.1 IRAK1 recruits IKK complex upon TLR7 8 or 9 stimulation ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS%REACTOME%R-RNO-390471.1 Association of TriC CCT with target proteins during biosynthesis NCAM SIGNALING FOR NEURITE OUT-GROWTH%REACTOME DATABASE ID RELEASE 66%10145367 NCAM signaling for neurite out-growth DOWNSTREAM SIGNAL TRANSDUCTION%REACTOME%R-RNO-186763.1 Downstream signal transduction HDR THROUGH HOMOLOGOUS RECOMBINATION (HRR) OR SINGLE STRAND ANNEALING (SSA)%REACTOME%R-RNO-5693567.1 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) NITRIC OXIDE STIMULATES GUANYLATE CYCLASE%REACTOME DATABASE ID RELEASE 66%10145601 Nitric oxide stimulates guanylate cyclase ER QUALITY CONTROL COMPARTMENT (ERQC)%REACTOME DATABASE ID RELEASE 66%10145712 ER Quality Control Compartment (ERQC) TRAFFICKING OF AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145593 Trafficking of AMPA receptors GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE%REACTOME%R-RNO-210500.1 Glutamate Neurotransmitter Release Cycle RAP1 SIGNALLING%REACTOME DATABASE ID RELEASE 66%10145480 Rap1 signalling MISMATCH REPAIR (MMR) DIRECTED BY MSH2:MSH6 (MUTSALPHA)%REACTOME DATABASE ID RELEASE 66%10146059 Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) INTERLEUKIN-36 PATHWAY%REACTOME%R-RNO-9014826.1 Interleukin-36 pathway SYNTHESIS OF PG%REACTOME%R-RNO-1483148.1 Synthesis of PG SYNTHESIS OF PI%REACTOME%R-RNO-1483226.1 Synthesis of PI SYNTHESIS OF ACTIVE UBIQUITIN: ROLES OF E1 AND E2 ENZYMES%REACTOME DATABASE ID RELEASE 66%10146214 Synthesis of active ubiquitin: roles of E1 and E2 enzymes CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE%REACTOME%R-RNO-442720.1 CREB phosphorylation through the activation of Adenylate Cyclase TNFR1-INDUCED NFKAPPAB SIGNALING PATHWAY%REACTOME DATABASE ID RELEASE 66%10146055 TNFR1-induced NFkappaB signaling pathway BIOSYNTHESIS OF MARESIN-LIKE SPMS%REACTOME DATABASE ID RELEASE 66%10146318 Biosynthesis of maresin-like SPMs CONJUGATION OF BENZOATE WITH GLYCINE%REACTOME%R-RNO-177135.1 Conjugation of benzoate with glycine ABC-FAMILY PROTEINS MEDIATED TRANSPORT%REACTOME DATABASE ID RELEASE 66%10145462 ABC-family proteins mediated transport TRANSPORT OF GLYCEROL FROM ADIPOCYTES TO THE LIVER BY AQUAPORINS%REACTOME DATABASE ID RELEASE 66%10145643 Transport of glycerol from adipocytes to the liver by Aquaporins DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE%REACTOME%R-RNO-606279.1 Deposition of new CENPA-containing nucleosomes at the centromere INTERCONVERSION OF 2-OXOGLUTARATE AND 2-HYDROXYGLUTARATE%REACTOME%R-RNO-880009.1 Interconversion of 2-oxoglutarate and 2-hydroxyglutarate HS-GAG DEGRADATION%REACTOME%R-RNO-2024096.1 HS-GAG degradation GABA B RECEPTOR ACTIVATION%REACTOME%R-RNO-977444.1 GABA B receptor activation GLYCEROPHOSPHOLIPID CATABOLISM%REACTOME DATABASE ID RELEASE 66%10146195 Glycerophospholipid catabolism PI3K AKT SIGNALING%REACTOME%R-RNO-1257604.1 PI3K AKT Signaling SUMOYLATION OF TRANSCRIPTION FACTORS%REACTOME%R-RNO-3232118.1 SUMOylation of transcription factors M PHASE%REACTOME%R-RNO-68886.1 M Phase ACTIVATION OF BID AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%R-RNO-75108.1 Activation of BID and translocation to mitochondria FGFR1C AND KLOTHO LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 66%10145295 FGFR1c and Klotho ligand binding and activation INTRAFLAGELLAR TRANSPORT%REACTOME%R-RNO-5620924.1 Intraflagellar transport BETA OXIDATION OF PALMITOYL-COA TO MYRISTOYL-COA%REACTOME DATABASE ID RELEASE 66%10144934 Beta oxidation of palmitoyl-CoA to myristoyl-CoA SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE%REACTOME DATABASE ID RELEASE 66%10145902 Synthesis of PIPs at the early endosome membrane RNA POLYMERASE II TRANSCRIPTION ELONGATION%REACTOME%R-RNO-75955.1 RNA Polymerase II Transcription Elongation TOLL LIKE RECEPTOR 5 (TLR5) CASCADE%REACTOME DATABASE ID RELEASE 66%10145157 Toll Like Receptor 5 (TLR5) Cascade GLUCOCORTICOID BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 66%10145323 Glucocorticoid biosynthesis REACTIONS SPECIFIC TO THE COMPLEX N-GLYCAN SYNTHESIS PATHWAY%REACTOME DATABASE ID RELEASE 66%10145779 Reactions specific to the complex N-glycan synthesis pathway SIGNALING BY INTERLEUKINS%REACTOME DATABASE ID RELEASE 66%10145163 Signaling by Interleukins DETOXIFICATION OF REACTIVE OXYGEN SPECIES%REACTOME%R-RNO-3299685.1 Detoxification of Reactive Oxygen Species PLASMA LIPOPROTEIN CLEARANCE%REACTOME%R-RNO-8964043.1 Plasma lipoprotein clearance PEROXISOMAL LIPID METABOLISM%REACTOME%R-RNO-390918.1 Peroxisomal lipid metabolism GAP JUNCTION ASSEMBLY%REACTOME%R-RNO-190861.1 Gap junction assembly DNA DAMAGE RECOGNITION IN GG-NER%REACTOME DATABASE ID RELEASE 66%10146144 DNA Damage Recognition in GG-NER MITOTIC METAPHASE AND ANAPHASE%REACTOME DATABASE ID RELEASE 66%10145109 Mitotic Metaphase and Anaphase POST NMDA RECEPTOR ACTIVATION EVENTS%REACTOME%R-RNO-438064.1 Post NMDA receptor activation events MAP KINASE ACTIVATION%REACTOME DATABASE ID RELEASE 66%10145160 MAP kinase activation NUCLEOBASE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 66%10144842 Nucleobase biosynthesis MITOCHONDRIAL TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 66%10145689 Mitochondrial tRNA aminoacylation PI3K AKT ACTIVATION%REACTOME DATABASE ID RELEASE 66%10145352 PI3K AKT activation PTK6 REGULATES PROTEINS INVOLVED IN RNA PROCESSING%REACTOME DATABASE ID RELEASE 66%10146207 PTK6 Regulates Proteins Involved in RNA Processing CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE%REACTOME%R-RNO-204998.1 Cell death signalling via NRAGE, NRIF and NADE SELENOAMINO ACID METABOLISM%REACTOME%R-RNO-2408522.1 Selenoamino acid metabolism CELL CYCLE CHECKPOINTS%REACTOME DATABASE ID RELEASE 66%10144741 Cell Cycle Checkpoints NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC)%REACTOME%R-RNO-975957.1 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) INTERLEUKIN-18 SIGNALING%REACTOME%R-RNO-9012546.1 Interleukin-18 signaling FRS-MEDIATED FGFR2 SIGNALING%REACTOME DATABASE ID RELEASE 66%10146103 FRS-mediated FGFR2 signaling BASE-EXCISION REPAIR, AP SITE FORMATION%REACTOME%R-RNO-73929.1 Base-Excision Repair, AP Site Formation RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER%REACTOME DATABASE ID RELEASE 66%10144947 RNA Polymerase III Transcription Initiation From Type 2 Promoter CYP2E1 REACTIONS%REACTOME%R-RNO-211999.1 CYP2E1 reactions TRANSLATION INITIATION COMPLEX FORMATION%REACTOME DATABASE ID RELEASE 66%10145076 Translation initiation complex formation UNBLOCKING OF NMDA RECEPTORS, GLUTAMATE BINDING AND ACTIVATION%REACTOME%R-RNO-438066.1 Unblocking of NMDA receptors, glutamate binding and activation CAMK IV-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%R-RNO-111932.1 CaMK IV-mediated phosphorylation of CREB LYSOSPHINGOLIPID AND LPA RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145608 Lysosphingolipid and LPA receptors METABOLISM OF INGESTED SEMET, SEC, MESEC INTO H2SE%REACTOME%R-RNO-2408508.1 Metabolism of ingested SeMet, Sec, MeSec into H2Se GLYCOSAMINOGLYCAN METABOLISM%REACTOME%R-RNO-1630316.1 Glycosaminoglycan metabolism RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 66%10144983 Resolution of AP sites via the multiple-nucleotide patch replacement pathway IGF1R SIGNALING CASCADE%REACTOME%R-RNO-2428924.1 IGF1R signaling cascade CELLULAR RESPONSES TO EXTERNAL STIMULI%REACTOME%R-RNO-8953897.1 Cellular responses to external stimuli CHYLOMICRON CLEARANCE%REACTOME%R-RNO-8964026.1 Chylomicron clearance HIGHLY SODIUM PERMEABLE ACETYLCHOLINE NICOTINIC RECEPTORS%REACTOME%R-RNO-629587.1 Highly sodium permeable acetylcholine nicotinic receptors NEGATIVE REGULATION OF MAPK PATHWAY%REACTOME%R-RNO-5675221.1 Negative regulation of MAPK pathway SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE%REACTOME DATABASE ID RELEASE 66%10145899 Synthesis of PIPs at the late endosome membrane ACETYLCHOLINE REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 66%10145585 Acetylcholine regulates insulin secretion RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS%REACTOME%R-RNO-674695.1 RNA Polymerase II Pre-transcription Events REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA)%REACTOME DATABASE ID RELEASE 66%10145590 Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) CONJUGATION OF SALICYLATE WITH GLYCINE%REACTOME%R-RNO-177128.1 Conjugation of salicylate with glycine CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY%REACTOME DATABASE ID RELEASE 66%10145212 Cyclin A:Cdk2-associated events at S phase entry NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 66%10145513 Nuclear Receptor transcription pathway AURKA ACTIVATION BY TPX2%REACTOME%R-RNO-8854518.1 AURKA Activation by TPX2 FATTY ACIDS%REACTOME%R-RNO-211935.1 Fatty acids MITOTIC PROPHASE%REACTOME DATABASE ID RELEASE 66%10145525 Mitotic Prophase THE RETINOID CYCLE IN CONES (DAYLIGHT VISION)%REACTOME DATABASE ID RELEASE 66%10145969 The retinoid cycle in cones (daylight vision) TERMINATION OF O-GLYCAN BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 66%10145784 Termination of O-glycan biosynthesis GLYCOGEN METABOLISM%REACTOME DATABASE ID RELEASE 66%10144770 Glycogen metabolism INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES%REACTOME%R-RNO-499943.1 Interconversion of nucleotide di- and triphosphates N-GLYCAN ANTENNAE ELONGATION%REACTOME DATABASE ID RELEASE 66%10145781 N-Glycan antennae elongation O-LINKED GLYCOSYLATION%REACTOME%R-RNO-5173105.1 O-linked glycosylation DNA REPLICATION INITIATION%REACTOME DATABASE ID RELEASE 66%10144718 DNA replication initiation PURINE SALVAGE%REACTOME DATABASE ID RELEASE 66%10144873 Purine salvage G-PROTEIN BETA:GAMMA SIGNALLING%REACTOME%R-RNO-397795.1 G-protein beta:gamma signalling ALTERNATIVE COMPLEMENT ACTIVATION%REACTOME DATABASE ID RELEASE 66%10145211 Alternative complement activation SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP)%REACTOME DATABASE ID RELEASE 66%10145264 Senescence-Associated Secretory Phenotype (SASP) SIGNALING BY INSULIN RECEPTOR%REACTOME%R-RNO-74752.1 Signaling by Insulin receptor SIGNALING BY NODAL%REACTOME%R-RNO-1181150.1 Signaling by NODAL PI3K EVENTS IN ERBB2 SIGNALING%REACTOME DATABASE ID RELEASE 66%10145823 PI3K events in ERBB2 signaling U12 DEPENDENT SPLICING%REACTOME%R-RNO-72165.1 U12 Dependent Splicing RHO GTPASES ACTIVATE PKNS%REACTOME%R-RNO-5625740.1 RHO GTPases activate PKNs C6 DEAMINATION OF ADENOSINE%REACTOME%R-RNO-75102.1 C6 deamination of adenosine SERINE BIOSYNTHESIS%REACTOME%R-RNO-977347.1 Serine biosynthesis NEGATIVE REGULATION OF THE PI3K AKT NETWORK%REACTOME%R-RNO-199418.1 Negative regulation of the PI3K AKT network METABOLISM OF FOLATE AND PTERINES%REACTOME%R-RNO-196757.1 Metabolism of folate and pterines ACTIVATION OF C3 AND C5%REACTOME%R-RNO-174577.1 Activation of C3 and C5 SHC-MEDIATED CASCADE:FGFR3%REACTOME%R-RNO-5654704.1 SHC-mediated cascade:FGFR3 BIOLOGICAL OXIDATIONS%REACTOME%R-RNO-211859.1 Biological oxidations NONCANONICAL ACTIVATION OF NOTCH3%REACTOME%R-RNO-9017802.1 Noncanonical activation of NOTCH3 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION)%REACTOME%R-RNO-2453902.1 The canonical retinoid cycle in rods (twilight vision) REGULATION OF TNFR1 SIGNALING%REACTOME DATABASE ID RELEASE 66%10146056 Regulation of TNFR1 signaling RNA POLYMERASE II PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 66%10144902 RNA Polymerase II Promoter Escape SUMOYLATION OF DNA METHYLATION PROTEINS%REACTOME%R-RNO-4655427.1 SUMOylation of DNA methylation proteins RUNX1 REGULATES ESTROGEN RECEPTOR MEDIATED TRANSCRIPTION%REACTOME DATABASE ID RELEASE 66%10146262 RUNX1 regulates estrogen receptor mediated transcription THREONINE CATABOLISM%REACTOME DATABASE ID RELEASE 66%10146296 Threonine catabolism METABOLISM OF RNA%REACTOME DATABASE ID RELEASE 66%10144827 Metabolism of RNA SYNTHESIS OF DOLICHYL-PHOSPHATE MANNOSE%REACTOME DATABASE ID RELEASE 66%10145103 Synthesis of dolichyl-phosphate mannose RNA POLYMERASE III TRANSCRIPTION INITIATION%REACTOME%R-RNO-76046.1 RNA Polymerase III Transcription Initiation ADENOSINE P1 RECEPTORS%REACTOME%R-RNO-417973.1 Adenosine P1 receptors WAX BIOSYNTHESIS%REACTOME%R-RNO-8848584.1 Wax biosynthesis ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 66%10145451 Acetylcholine Neurotransmitter Release Cycle TRAIL SIGNALING%REACTOME%R-RNO-75158.1 TRAIL signaling DIGESTION%REACTOME DATABASE ID RELEASE 66%10145278 Digestion CELLULAR SENESCENCE%REACTOME%R-RNO-2559583.1 Cellular Senescence G ALPHA (S) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 66%10145517 G alpha (s) signalling events TNFR1-MEDIATED CERAMIDE PRODUCTION%REACTOME DATABASE ID RELEASE 66%10146089 TNFR1-mediated ceramide production SIGNALING BY RETINOIC ACID%REACTOME DATABASE ID RELEASE 66%10145381 Signaling by Retinoic Acid DIMERIZATION OF PROCASPASE-8%REACTOME%R-RNO-69416.1 Dimerization of procaspase-8 REGULATION OF GAP JUNCTION ACTIVITY%REACTOME DATABASE ID RELEASE 66%10145308 Regulation of gap junction activity PROLONGED ERK ACTIVATION EVENTS%REACTOME DATABASE ID RELEASE 66%10145181 Prolonged ERK activation events RELEASE OF APOPTOTIC FACTORS FROM THE MITOCHONDRIA%REACTOME DATABASE ID RELEASE 66%10145018 Release of apoptotic factors from the mitochondria SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE%REACTOME%R-RNO-1660499.1 Synthesis of PIPs at the plasma membrane TRANSPORT AND SYNTHESIS OF PAPS%REACTOME%R-RNO-174362.1 Transport and synthesis of PAPS DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING%REACTOME DATABASE ID RELEASE 66%10145207 Downregulation of TGF-beta receptor signaling SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI)%REACTOME%R-RNO-162710.1 Synthesis of glycosylphosphatidylinositol (GPI) INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS%REACTOME%R-RNO-997272.1 Inhibition of voltage gated Ca2+ channels via Gbeta gamma subunits PROTON-COUPLED NEUTRAL AMINO ACID TRANSPORTERS%REACTOME DATABASE ID RELEASE 66%10145510 Proton-coupled neutral amino acid transporters ERYTHROPOIETIN ACTIVATES PHOSPHOINOSITIDE-3-KINASE (PI3K)%REACTOME DATABASE ID RELEASE 66%10146294 Erythropoietin activates Phosphoinositide-3-kinase (PI3K) METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS%REACTOME DATABASE ID RELEASE 66%10145925 Metabolism of Angiotensinogen to Angiotensins ION CHANNEL TRANSPORT%REACTOME DATABASE ID RELEASE 66%10145600 Ion channel transport CREB3 FACTORS ACTIVATE GENES%REACTOME DATABASE ID RELEASE 66%10146248 CREB3 factors activate genes ORC1 REMOVAL FROM CHROMATIN%REACTOME%R-RNO-68949.1 Orc1 removal from chromatin SIGNALING BY FGFR2%REACTOME DATABASE ID RELEASE 66%10145256 Signaling by FGFR2 AMINE OXIDASE REACTIONS%REACTOME DATABASE ID RELEASE 66%10145056 Amine Oxidase reactions TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION%REACTOME%R-RNO-948021.1 Transport to the Golgi and subsequent modification L1CAM INTERACTIONS%REACTOME DATABASE ID RELEASE 66%10144965 L1CAM interactions PROLACTIN RECEPTOR SIGNALING%REACTOME DATABASE ID RELEASE 66%10145783 Prolactin receptor signaling ACETYLATION%REACTOME DATABASE ID RELEASE 66%10145083 Acetylation CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII%REACTOME DATABASE ID RELEASE 66%10145658 CREB phosphorylation through the activation of CaMKII FORMATION OF XYLULOSE-5-PHOSPHATE%REACTOME DATABASE ID RELEASE 66%10146116 Formation of xylulose-5-phosphate BETA DEFENSINS%REACTOME DATABASE ID RELEASE 66%10145858 Beta defensins GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY%REACTOME%R-RNO-399721.1 Glutamate binding, activation of AMPA receptors and synaptic plasticity STRIATED MUSCLE CONTRACTION%REACTOME%R-RNO-390522.1 Striated Muscle Contraction ABC TRANSPORTERS IN LIPID HOMEOSTASIS%REACTOME DATABASE ID RELEASE 66%10145461 ABC transporters in lipid homeostasis RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF MYELOID CELLS%REACTOME DATABASE ID RELEASE 66%10146266 RUNX1 regulates transcription of genes involved in differentiation of myeloid cells ESR-MEDIATED SIGNALING%REACTOME DATABASE ID RELEASE 66%10145830 ESR-mediated signaling G ALPHA (Q) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 66%10145036 G alpha (q) signalling events PI3K EVENTS IN ERBB4 SIGNALING%REACTOME%R-RNO-1250342.1 PI3K events in ERBB4 signaling CGMP EFFECTS%REACTOME%R-RNO-418457.1 cGMP effects INTERACTION BETWEEN PHLDA1 AND AURKA%REACTOME DATABASE ID RELEASE 66%10146219 Interaction between PHLDA1 and AURKA G-PROTEIN MEDIATED EVENTS%REACTOME%R-RNO-112040.1 G-protein mediated events ERBB2 REGULATES CELL MOTILITY%REACTOME DATABASE ID RELEASE 66%10146156 ERBB2 Regulates Cell Motility S PHASE%REACTOME%R-RNO-69242.1 S Phase IL-6-TYPE CYTOKINE RECEPTOR LIGAND INTERACTIONS%REACTOME DATABASE ID RELEASE 66%10145682 IL-6-type cytokine receptor ligand interactions VESICLE-MEDIATED TRANSPORT%REACTOME DATABASE ID RELEASE 66%10145300 Vesicle-mediated transport CONJUGATION OF PHENYLACETATE WITH GLUTAMINE%REACTOME DATABASE ID RELEASE 66%10145246 Conjugation of phenylacetate with glutamine SIGNALING BY FGFR1%REACTOME%R-RNO-5654736.1 Signaling by FGFR1 RNA POLYMERASE I CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 66%10144884 RNA Polymerase I Chain Elongation INTERLEUKIN-17 SIGNALING%REACTOME%R-RNO-448424.1 Interleukin-17 signaling HDMS DEMETHYLATE HISTONES%REACTOME DATABASE ID RELEASE 66%10145998 HDMs demethylate histones RNA POLYMERASE I TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 66%10144850 RNA Polymerase I Transcription Initiation SCAVENGING OF HEME FROM PLASMA%REACTOME%R-RNO-2168880.1 Scavenging of heme from plasma MAP3K8 (TPL2)-DEPENDENT MAPK1 3 ACTIVATION%REACTOME DATABASE ID RELEASE 66%10145702 MAP3K8 (TPL2)-dependent MAPK1 3 activation SYNTHESIS OF 5-EICOSATETRAENOIC ACIDS%REACTOME%R-RNO-2142688.1 Synthesis of 5-eicosatetraenoic acids MYOGENESIS%REACTOME%R-RNO-525793.1 Myogenesis CHONDROITIN SULFATE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 66%10145919 Chondroitin sulfate biosynthesis SIGNALING BY LEPTIN%REACTOME DATABASE ID RELEASE 66%10145709 Signaling by Leptin ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1%REACTOME DATABASE ID RELEASE 66%10145597 ADP signalling through P2Y purinoceptor 1 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE%REACTOME%R-RNO-2559586.1 DNA Damage Telomere Stress Induced Senescence FATTY ACYL-COA BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 66%10144901 Fatty acyl-CoA biosynthesis P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME%R-RNO-69580.1 p53-Dependent G1 S DNA damage checkpoint RSK ACTIVATION%REACTOME DATABASE ID RELEASE 66%10145660 RSK activation PROCESSING OF CAPPED INTRONLESS PRE-MRNA%REACTOME%R-RNO-75067.1 Processing of Capped Intronless Pre-mRNA DUAL INCISION IN GG-NER%REACTOME DATABASE ID RELEASE 66%10146140 Dual Incision in GG-NER CONDENSATION OF PROPHASE CHROMOSOMES%REACTOME DATABASE ID RELEASE 66%10145955 Condensation of Prophase Chromosomes REGULATION OF TP53 ACTIVITY%REACTOME%R-RNO-5633007.1 Regulation of TP53 Activity MICROTUBULE-DEPENDENT TRAFFICKING OF CONNEXONS FROM GOLGI TO THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 66%10145301 Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane ER TO GOLGI ANTEROGRADE TRANSPORT%REACTOME%R-RNO-199977.1 ER to Golgi Anterograde Transport IRON UPTAKE AND TRANSPORT%REACTOME DATABASE ID RELEASE 66%10145283 Iron uptake and transport CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION%REACTOME DATABASE ID RELEASE 66%10145415 Class I MHC mediated antigen processing & presentation POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%R-RNO-622327.1 Postsynaptic nicotinic acetylcholine receptors INTERLEUKIN-15 SIGNALING%REACTOME%R-RNO-8983432.1 Interleukin-15 signaling CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE%REACTOME%R-RNO-176407.1 Conversion from APC C:Cdc20 to APC C:Cdh1 in late anaphase ACTIVATED NTRK2 SIGNALS THROUGH FYN%REACTOME DATABASE ID RELEASE 66%10146323 Activated NTRK2 signals through FYN MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF SATURATED FATTY ACIDS%REACTOME%R-RNO-77286.1 mitochondrial fatty acid beta-oxidation of saturated fatty acids MET ACTIVATES RAP1 AND RAC1%REACTOME DATABASE ID RELEASE 66%10146252 MET activates RAP1 and RAC1 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION%REACTOME%R-RNO-156827.1 L13a-mediated translational silencing of Ceruloplasmin expression HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME%R-RNO-5693579.1 Homologous DNA Pairing and Strand Exchange P75NTR SIGNALS VIA NF-KB%REACTOME%R-RNO-193639.1 p75NTR signals via NF-kB CELL-CELL COMMUNICATION%REACTOME DATABASE ID RELEASE 66%10145431 Cell-Cell communication RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASES%REACTOME DATABASE ID RELEASE 66%10145543 Receptor-type tyrosine-protein phosphatases SULFIDE OXIDATION TO SULFATE%REACTOME DATABASE ID RELEASE 66%10145889 Sulfide oxidation to sulfate SIGNALING BY EGFR%REACTOME DATABASE ID RELEASE 66%10144957 Signaling by EGFR INVADOPODIA FORMATION%REACTOME DATABASE ID RELEASE 66%10146271 Invadopodia formation P53-DEPENDENT G1 DNA DAMAGE RESPONSE%REACTOME%R-RNO-69563.1 p53-Dependent G1 DNA Damage Response METAL SEQUESTRATION BY ANTIMICROBIAL PROTEINS%REACTOME DATABASE ID RELEASE 66%10145804 Metal sequestration by antimicrobial proteins SUMOYLATION OF IMMUNE RESPONSE PROTEINS%REACTOME%R-RNO-4755510.1 SUMOylation of immune response proteins LYSINE CATABOLISM%REACTOME%R-RNO-71064.1 Lysine catabolism ARL13B-MEDIATED CILIARY TRAFFICKING OF INPP5E%REACTOME DATABASE ID RELEASE 66%10146085 ARL13B-mediated ciliary trafficking of INPP5E TRANSPORT OF FATTY ACIDS%REACTOME%R-RNO-804914.1 Transport of fatty acids COPI-DEPENDENT GOLGI-TO-ER RETROGRADE TRAFFIC%REACTOME%R-RNO-6811434.1 COPI-dependent Golgi-to-ER retrograde traffic METABOLISM OF PROTEINS%REACTOME DATABASE ID RELEASE 66%10144825 Metabolism of proteins IRF3-MEDIATED INDUCTION OF TYPE I IFN%REACTOME DATABASE ID RELEASE 66%10145930 IRF3-mediated induction of type I IFN REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION%REACTOME%R-RNO-2565942.1 Regulation of PLK1 Activity at G2 M Transition INTERLEUKIN-33 SIGNALING%REACTOME%R-RNO-9014843.1 Interleukin-33 signaling MHC CLASS II ANTIGEN PRESENTATION%REACTOME DATABASE ID RELEASE 66%10145936 MHC class II antigen presentation DNA REPLICATION%REACTOME%R-RNO-69306.1 DNA Replication ARYL HYDROCARBON RECEPTOR SIGNALLING%REACTOME DATABASE ID RELEASE 66%10146264 Aryl hydrocarbon receptor signalling ISG15 ANTIVIRAL MECHANISM%REACTOME DATABASE ID RELEASE 66%10145800 ISG15 antiviral mechanism GENERIC TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 66%10144749 Generic Transcription Pathway ACYL CHAIN REMODELING OF CL%REACTOME%R-RNO-1482798.1 Acyl chain remodeling of CL VOLTAGE GATED POTASSIUM CHANNELS%REACTOME DATABASE ID RELEASE 66%10145837 Voltage gated Potassium channels ADHERENS JUNCTIONS INTERACTIONS%REACTOME DATABASE ID RELEASE 66%10145606 Adherens junctions interactions BETA-OXIDATION OF PRISTANOYL-COA%REACTOME%R-RNO-389887.1 Beta-oxidation of pristanoyl-CoA SEMA4D IN SEMAPHORIN SIGNALING%REACTOME%R-RNO-400685.1 Sema4D in semaphorin signaling TRANSCRIPTIONAL REGULATION BY E2F6%REACTOME%R-RNO-8953750.1 Transcriptional Regulation by E2F6 SUMOYLATION OF DNA DAMAGE RESPONSE AND REPAIR PROTEINS%REACTOME%R-RNO-3108214.1 SUMOylation of DNA damage response and repair proteins ERK1 ERK2 PATHWAY%REACTOME DATABASE ID RELEASE 66%10144961 ERK1 ERK2 pathway TOLL LIKE RECEPTOR 9 (TLR9) CASCADE%REACTOME DATABASE ID RELEASE 66%10145153 Toll Like Receptor 9 (TLR9) Cascade GLUCAGON SIGNALING IN METABOLIC REGULATION%REACTOME DATABASE ID RELEASE 66%10145003 Glucagon signaling in metabolic regulation ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION%REACTOME DATABASE ID RELEASE 66%10145786 Antigen processing: Ubiquitination & Proteasome degradation GAP JUNCTION TRAFFICKING%REACTOME%R-RNO-190828.1 Gap junction trafficking REGULATION OF PTEN STABILITY AND ACTIVITY%REACTOME DATABASE ID RELEASE 66%10146185 Regulation of PTEN stability and activity EXTRINSIC PATHWAY OF FIBRIN CLOT FORMATION%REACTOME DATABASE ID RELEASE 66%10145054 Extrinsic Pathway of Fibrin Clot Formation MITOCHONDRIAL TRANSLATION ELONGATION%REACTOME DATABASE ID RELEASE 66%10146063 Mitochondrial translation elongation TRANSFER OF LPS FROM LBP CARRIER TO CD14%REACTOME%R-RNO-166020.1 Transfer of LPS from LBP carrier to CD14 ENOS ACTIVATION AND REGULATION%REACTOME%R-RNO-203765.1 eNOS activation and regulation G2 M TRANSITION%REACTOME%R-RNO-69275.1 G2 M Transition SYNTHESIS OF GDP-MANNOSE%REACTOME DATABASE ID RELEASE 66%10145672 Synthesis of GDP-mannose PI-3K CASCADE:FGFR3%REACTOME DATABASE ID RELEASE 66%10145257 PI-3K cascade:FGFR3 PAOS OXIDISE POLYAMINES TO AMINES%REACTOME DATABASE ID RELEASE 66%10145060 PAOs oxidise polyamines to amines DOWNREGULATION OF ERBB4 SIGNALING%REACTOME DATABASE ID RELEASE 66%10145828 Downregulation of ERBB4 signaling REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION%REACTOME%R-RNO-2029482.1 Regulation of actin dynamics for phagocytic cup formation TERMINAL PATHWAY OF COMPLEMENT%REACTOME DATABASE ID RELEASE 66%10145210 Terminal pathway of complement REGULATION OF RUNX1 EXPRESSION AND ACTIVITY%REACTOME%R-RNO-8934593.1 Regulation of RUNX1 Expression and Activity INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%R-RNO-2514859.1 Inactivation, recovery and regulation of the phototransduction cascade GENERATION OF SECOND MESSENGER MOLECULES%REACTOME DATABASE ID RELEASE 66%10145400 Generation of second messenger molecules MITOCHONDRIAL TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 66%10145119 Mitochondrial transcription termination CLEAVAGE OF THE DAMAGED PYRIMIDINE%REACTOME%R-RNO-110329.1 Cleavage of the damaged pyrimidine INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME DATABASE ID RELEASE 66%10145016 Intrinsic Pathway for Apoptosis PHASE 3 - RAPID REPOLARISATION%REACTOME%R-RNO-5576890.1 Phase 3 - rapid repolarisation TRANSLESION SYNTHESIS BY POLH%REACTOME%R-RNO-110320.1 Translesion Synthesis by POLH PLATELET CALCIUM HOMEOSTASIS%REACTOME%R-RNO-418360.1 Platelet calcium homeostasis NUCLEAR ENVELOPE REASSEMBLY%REACTOME%R-RNO-2995410.1 Nuclear Envelope Reassembly DAG AND IP3 SIGNALING%REACTOME%R-RNO-1489509.1 DAG and IP3 signaling ION INFLUX EFFLUX AT HOST-PATHOGEN INTERFACE%REACTOME%R-RNO-6803544.1 Ion influx efflux at host-pathogen interface GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER%REACTOME DATABASE ID RELEASE 66%10146143 Gap-filling DNA repair synthesis and ligation in GG-NER PYRIMIDINE CATABOLISM%REACTOME%R-RNO-73621.1 Pyrimidine catabolism GLYCOLYSIS%REACTOME DATABASE ID RELEASE 66%10144768 Glycolysis MOLECULES ASSOCIATED WITH ELASTIC FIBRES%REACTOME DATABASE ID RELEASE 66%10145882 Molecules associated with elastic fibres OXIDATIVE DEMETHYLATION OF DNA%REACTOME DATABASE ID RELEASE 66%10146048 Oxidative demethylation of DNA TRANSPORT OF CONNEXONS TO THE PLASMA MEMBRANE%REACTOME%R-RNO-190872.1 Transport of connexons to the plasma membrane RRNA PROCESSING%REACTOME DATABASE ID RELEASE 66%10146163 rRNA processing AGMATINE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 66%10145466 Agmatine biosynthesis MUSCARINIC ACETYLCHOLINE RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145559 Muscarinic acetylcholine receptors ACTIVATED NTRK2 SIGNALS THROUGH PLCG1%REACTOME%R-RNO-9026527.1 Activated NTRK2 signals through PLCG1 KETONE BODY METABOLISM%REACTOME DATABASE ID RELEASE 66%10144854 Ketone body metabolism TYPE II NA+ PI COTRANSPORTERS%REACTOME DATABASE ID RELEASE 66%10145628 Type II Na+ Pi cotransporters TRAF3-DEPENDENT IRF ACTIVATION PATHWAY%REACTOME DATABASE ID RELEASE 66%10145795 TRAF3-dependent IRF activation pathway ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX%REACTOME%R-RNO-68867.1 Assembly of the pre-replicative complex SYNTHESIS OF PC%REACTOME DATABASE ID RELEASE 66%10145452 Synthesis of PC HYALURONAN UPTAKE AND DEGRADATION%REACTOME%R-RNO-2160916.1 Hyaluronan uptake and degradation SIGNALING BY NOTCH1%REACTOME DATABASE ID RELEASE 66%10145913 Signaling by NOTCH1 PASSIVE TRANSPORT BY AQUAPORINS%REACTOME DATABASE ID RELEASE 66%10145707 Passive transport by Aquaporins NCAM1 INTERACTIONS%REACTOME DATABASE ID RELEASE 66%10145505 NCAM1 interactions SIALIC ACID METABOLISM%REACTOME DATABASE ID RELEASE 66%10145633 Sialic acid metabolism G1 S DNA DAMAGE CHECKPOINTS%REACTOME DATABASE ID RELEASE 66%10144740 G1 S DNA Damage Checkpoints SODIUM-COUPLED PHOSPHATE COTRANSPORTERS%REACTOME DATABASE ID RELEASE 66%10145627 Sodium-coupled phosphate cotransporters REGULATION OF COMMISSURAL AXON PATHFINDING BY SLIT AND ROBO%REACTOME DATABASE ID RELEASE 66%10145632 Regulation of commissural axon pathfinding by SLIT and ROBO REGULATION OF PTEN LOCALIZATION%REACTOME%R-RNO-8948747.1 Regulation of PTEN localization PHASE II - CONJUGATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 66%10144773 Phase II - Conjugation of compounds TRANSFERRIN ENDOCYTOSIS AND RECYCLING%REACTOME%R-RNO-917977.1 Transferrin endocytosis and recycling NECTIN NECL TRANS HETERODIMERIZATION%REACTOME DATABASE ID RELEASE 66%10145613 Nectin Necl trans heterodimerization REGULATION OF FZD BY UBIQUITINATION%REACTOME DATABASE ID RELEASE 66%10146037 Regulation of FZD by ubiquitination FGFR3B LIGAND BINDING AND ACTIVATION%REACTOME%R-RNO-190371.1 FGFR3b ligand binding and activation ION HOMEOSTASIS%REACTOME DATABASE ID RELEASE 66%10145041 Ion homeostasis DEVELOPMENTAL BIOLOGY%REACTOME DATABASE ID RELEASE 66%10144967 Developmental Biology GPCR DOWNSTREAM SIGNALLING%REACTOME DATABASE ID RELEASE 66%10144869 GPCR downstream signalling PHOSPHATE BOND HYDROLYSIS BY NTPDASE PROTEINS%REACTOME DATABASE ID RELEASE 66%10146210 Phosphate bond hydrolysis by NTPDase proteins ANTAGONISM OF ACTIVIN BY FOLLISTATIN%REACTOME%R-RNO-2473224.1 Antagonism of Activin by Follistatin PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR%REACTOME%R-RNO-392851.1 Prostacyclin signalling through prostacyclin receptor CHOLINE CATABOLISM%REACTOME%R-RNO-6798163.1 Choline catabolism MULTIFUNCTIONAL ANION EXCHANGERS%REACTOME DATABASE ID RELEASE 66%10145626 Multifunctional anion exchangers TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 66%10144823 tRNA Aminoacylation OLFACTORY SIGNALING PATHWAY%REACTOME%R-RNO-381753.1 Olfactory Signaling Pathway VLDLR INTERNALISATION AND DEGRADATION%REACTOME%R-RNO-8866427.1 VLDLR internalisation and degradation BETA OXIDATION OF HEXANOYL-COA TO BUTANOYL-COA%REACTOME%R-RNO-77350.1 Beta oxidation of hexanoyl-CoA to butanoyl-CoA FANCONI ANEMIA PATHWAY%REACTOME%R-RNO-6783310.1 Fanconi Anemia Pathway REGULATION OF TP53 ACTIVITY THROUGH ASSOCIATION WITH CO-FACTORS%REACTOME%R-RNO-6804759.1 Regulation of TP53 Activity through Association with Co-factors CLEC7A (DECTIN-1) INDUCES NFAT ACTIVATION%REACTOME%R-RNO-5607763.1 CLEC7A (Dectin-1) induces NFAT activation GP1B-IX-V ACTIVATION SIGNALLING%REACTOME DATABASE ID RELEASE 66%10145640 GP1b-IX-V activation signalling CATION-COUPLED CHLORIDE COTRANSPORTERS%REACTOME DATABASE ID RELEASE 66%10145620 Cation-coupled Chloride cotransporters FGFRL1 MODULATION OF FGFR1 SIGNALING%REACTOME%R-RNO-5658623.1 FGFRL1 modulation of FGFR1 signaling APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS%REACTOME%R-RNO-111465.1 Apoptotic cleavage of cellular proteins MICRORNA (MIRNA) BIOGENESIS%REACTOME%R-RNO-203927.1 MicroRNA (miRNA) biogenesis STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES%REACTOME%R-RNO-1834941.1 STING mediated induction of host immune responses MEIOTIC RECOMBINATION%REACTOME%R-RNO-912446.1 Meiotic recombination RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF KERATINOCYTES%REACTOME DATABASE ID RELEASE 66%10146265 RUNX1 regulates transcription of genes involved in differentiation of keratinocytes MITOCHONDRIAL PROTEIN IMPORT%REACTOME DATABASE ID RELEASE 66%10146287 Mitochondrial protein import ENZYMATIC DEGRADATION OF DOPAMINE BY MONOAMINE OXIDASE%REACTOME DATABASE ID RELEASE 66%10145518 Enzymatic degradation of Dopamine by monoamine oxidase G ALPHA (Z) SIGNALLING EVENTS%REACTOME%R-RNO-418597.1 G alpha (z) signalling events SURFACTANT METABOLISM%REACTOME DATABASE ID RELEASE 66%10145605 Surfactant metabolism AUTODEGRADATION OF CDH1 BY CDH1:APC C%REACTOME DATABASE ID RELEASE 66%10145213 Autodegradation of Cdh1 by Cdh1:APC C GLYCOPROTEIN HORMONES%REACTOME DATABASE ID RELEASE 66%10145514 Glycoprotein hormones RRNA PROCESSING IN THE NUCLEUS AND CYTOSOL%REACTOME DATABASE ID RELEASE 66%10146162 rRNA processing in the nucleus and cytosol INITIATION OF NUCLEAR ENVELOPE REFORMATION%REACTOME DATABASE ID RELEASE 66%10145989 Initiation of Nuclear Envelope Reformation METABOLISM OF STEROIDS%REACTOME DATABASE ID RELEASE 66%10145088 Metabolism of steroids REGULATION OF GENE EXPRESSION IN BETA CELLS%REACTOME%R-RNO-210745.1 Regulation of gene expression in beta cells ACTIVATION OF BH3-ONLY PROTEINS%REACTOME DATABASE ID RELEASE 66%10145046 Activation of BH3-only proteins EXPRESSION AND PROCESSING OF NEUROTROPHINS%REACTOME%R-RNO-9036866.1 Expression and Processing of Neurotrophins G2 PHASE%REACTOME DATABASE ID RELEASE 66%10145274 G2 Phase CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION%REACTOME%R-RNO-109688.1 Cleavage of Growing Transcript in the Termination Region CA2+ PATHWAY%REACTOME DATABASE ID RELEASE 66%10145578 Ca2+ pathway VITAMIN E%REACTOME DATABASE ID RELEASE 66%10146249 Vitamin E INTRACELLULAR SIGNALING BY SECOND MESSENGERS%REACTOME DATABASE ID RELEASE 66%10144994 Intracellular signaling by second messengers RECEPTOR MEDIATED MITOPHAGY%REACTOME DATABASE ID RELEASE 66%10146273 Receptor Mediated Mitophagy SOS-MEDIATED SIGNALLING%REACTOME%R-RNO-112412.1 SOS-mediated signalling TCF DEPENDENT SIGNALING IN RESPONSE TO WNT%REACTOME%R-RNO-201681.1 TCF dependent signaling in response to WNT OTHER INTERLEUKIN SIGNALING%REACTOME%R-RNO-449836.1 Other interleukin signaling INTRA-GOLGI TRAFFIC%REACTOME DATABASE ID RELEASE 66%10146194 Intra-Golgi traffic GRB2 EVENTS IN ERBB2 SIGNALING%REACTOME DATABASE ID RELEASE 66%10145849 GRB2 events in ERBB2 signaling DAP12 INTERACTIONS%REACTOME%R-RNO-2172127.1 DAP12 interactions ORGANIC ANION TRANSPORT%REACTOME%R-RNO-561048.1 Organic anion transport TRYPTOPHAN CATABOLISM%REACTOME%R-RNO-71240.1 Tryptophan catabolism SYNTHESIS OF LIPOXINS (LX)%REACTOME DATABASE ID RELEASE 66%10145463 Synthesis of Lipoxins (LX) AXONAL GROWTH STIMULATION%REACTOME%R-RNO-209563.1 Axonal growth stimulation SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL%REACTOME%R-RNO-1855183.1 Synthesis of IP2, IP, and Ins in the cytosol RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 66%10144903 RNA Polymerase II Transcription Initiation And Promoter Clearance SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21%REACTOME DATABASE ID RELEASE 66%10145271 SCF(Skp2)-mediated degradation of p27 p21 GLYOXYLATE METABOLISM AND GLYCINE DEGRADATION%REACTOME%R-RNO-389661.1 Glyoxylate metabolism and glycine degradation ERYTHROPOIETIN ACTIVATES RAS%REACTOME DATABASE ID RELEASE 66%10146321 Erythropoietin activates RAS MITOCHONDRIAL UNCOUPLING PROTEINS%REACTOME DATABASE ID RELEASE 66%10145136 Mitochondrial Uncoupling Proteins INTERACTION BETWEEN L1 AND ANKYRINS%REACTOME DATABASE ID RELEASE 66%10145576 Interaction between L1 and Ankyrins REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX%REACTOME%R-RNO-204174.1 Regulation of pyruvate dehydrogenase (PDH) complex ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S%REACTOME%R-RNO-72662.1 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S SYNTHESIS OF DOLICHYL-PHOSPHATE%REACTOME DATABASE ID RELEASE 66%10145306 Synthesis of Dolichyl-phosphate KETONE BODY CATABOLISM%REACTOME%R-RNO-77108.1 Ketone body catabolism REDUCTION OF CYTOSOLIC CA++ LEVELS%REACTOME%R-RNO-418359.1 Reduction of cytosolic Ca++ levels TCR SIGNALING%REACTOME DATABASE ID RELEASE 66%10145376 TCR signaling SUMOYLATION%REACTOME%R-RNO-2990846.1 SUMOylation CALMODULIN INDUCED EVENTS%REACTOME DATABASE ID RELEASE 66%10144991 Calmodulin induced events ACTIVATION OF PKB%REACTOME DATABASE ID RELEASE 66%10144955 Activation of PKB MET ACTIVATES PTK2 SIGNALING%REACTOME DATABASE ID RELEASE 66%10146246 MET activates PTK2 signaling OPIOID SIGNALLING%REACTOME%R-RNO-111885.1 Opioid Signalling SIGNALING BY ERBB2%REACTOME%R-RNO-1227986.1 Signaling by ERBB2 PHASE 0 - RAPID DEPOLARISATION%REACTOME DATABASE ID RELEASE 66%10146067 Phase 0 - rapid depolarisation MISCELLANEOUS SUBSTRATES%REACTOME DATABASE ID RELEASE 66%10145442 Miscellaneous substrates HATS ACETYLATE HISTONES%REACTOME%R-RNO-3214847.1 HATs acetylate histones REGULATION OF IFNA SIGNALING%REACTOME%R-RNO-912694.1 Regulation of IFNA signaling ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES%REACTOME%R-RNO-1169410.1 Antiviral mechanism by IFN-stimulated genes SIGNALING BY NOTCH4%REACTOME DATABASE ID RELEASE 66%10146330 Signaling by NOTCH4 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM%REACTOME DATABASE ID RELEASE 66%10144804 Cobalamin (Cbl, vitamin B12) transport and metabolism ASSEMBLY OF ACTIVE LPL AND LIPC LIPASE COMPLEXES%REACTOME DATABASE ID RELEASE 66%10146149 Assembly of active LPL and LIPC lipase complexes SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX)%REACTOME%R-RNO-2162123.1 Synthesis of Prostaglandins (PG) and Thromboxanes (TX) INTERLEUKIN-38 SIGNALING%REACTOME DATABASE ID RELEASE 66%10146291 Interleukin-38 signaling AUF1 (HNRNP D0) BINDS AND DESTABILIZES MRNA%REACTOME DATABASE ID RELEASE 66%10145697 AUF1 (hnRNP D0) binds and destabilizes mRNA CYTOKINE SIGNALING IN IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 66%10145164 Cytokine Signaling in Immune system FORMATION OF A POOL OF FREE 40S SUBUNITS%REACTOME%R-RNO-72689.1 Formation of a pool of free 40S subunits LRR FLII-INTERACTING PROTEIN 1 (LRRFIP1) ACTIVATES TYPE I IFN PRODUCTION%REACTOME%R-RNO-3134973.1 LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production DISSOLUTION OF FIBRIN CLOT%REACTOME DATABASE ID RELEASE 66%10145082 Dissolution of Fibrin Clot RESOLUTION OF D-LOOP STRUCTURES THROUGH HOLLIDAY JUNCTION INTERMEDIATES%REACTOME%R-RNO-5693568.1 Resolution of D-loop Structures through Holliday Junction Intermediates RETINOID METABOLISM AND TRANSPORT%REACTOME DATABASE ID RELEASE 66%10145777 Retinoid metabolism and transport METABOLISM OF VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 66%10144806 Metabolism of vitamins and cofactors FIBRONECTIN MATRIX FORMATION%REACTOME%R-RNO-1566977.1 Fibronectin matrix formation RMTS METHYLATE HISTONE ARGININES%REACTOME%R-RNO-3214858.1 RMTs methylate histone arginines AMPK INHIBITS CHREBP TRANSCRIPTIONAL ACTIVATION ACTIVITY%REACTOME DATABASE ID RELEASE 66%10145123 AMPK inhibits chREBP transcriptional activation activity MAPK FAMILY SIGNALING CASCADES%REACTOME%R-RNO-5683057.1 MAPK family signaling cascades ACTIVATION OF NIMA KINASES NEK9, NEK6, NEK7%REACTOME%R-RNO-2980767.1 Activation of NIMA Kinases NEK9, NEK6, NEK7 CYSTEINE FORMATION FROM HOMOCYSTEINE%REACTOME%R-RNO-1614603.1 Cysteine formation from homocysteine NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION)%REACTOME%R-RNO-198725.1 Nuclear Events (kinase and transcription factor activation) PYRIMIDINE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 66%10144841 Pyrimidine biosynthesis ADAPTIVE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 66%10145356 Adaptive Immune System RAF-INDEPENDENT MAPK1 3 ACTIVATION%REACTOME DATABASE ID RELEASE 66%10144960 RAF-independent MAPK1 3 activation RNA POLYMERASE II TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 66%10144832 RNA Polymerase II Transcription Termination SYNTHESIS OF KETONE BODIES%REACTOME%R-RNO-77111.1 Synthesis of Ketone Bodies LACTOSE SYNTHESIS%REACTOME DATABASE ID RELEASE 66%10146097 Lactose synthesis DOWNSTREAM SIGNALING OF ACTIVATED FGFR4%REACTOME DATABASE ID RELEASE 66%10145261 Downstream signaling of activated FGFR4 VXPX CARGO-TARGETING TO CILIUM%REACTOME DATABASE ID RELEASE 66%10146083 VxPx cargo-targeting to cilium THE ROLE OF GTSE1 IN G2 M PROGRESSION AFTER G2 CHECKPOINT%REACTOME%R-RNO-8852276.1 The role of GTSE1 in G2 M progression after G2 checkpoint TWIK-RELATED SPINAL CORD K+ CHANNEL (TRESK)%REACTOME DATABASE ID RELEASE 66%10145846 TWIK-related spinal cord K+ channel (TRESK) NEUROTRANSMITTER RELEASE CYCLE%REACTOME%R-RNO-112310.1 Neurotransmitter release cycle FREE FATTY ACID RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145661 Free fatty acid receptors MAPK1 (ERK2) ACTIVATION%REACTOME DATABASE ID RELEASE 66%10144963 MAPK1 (ERK2) activation PROCESSING AND ACTIVATION OF SUMO%REACTOME%R-RNO-3215018.1 Processing and activation of SUMO RNA POLYMERASE II TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 66%10144905 RNA Polymerase II Transcription Initiation RUNX3 REGULATES WNT SIGNALING%REACTOME DATABASE ID RELEASE 66%10146277 RUNX3 regulates WNT signaling FORMATION OF EDITOSOMES BY ADAR PROTEINS%REACTOME%R-RNO-77042.1 Formation of editosomes by ADAR proteins ARACHIDONIC ACID METABOLISM%REACTOME%R-RNO-2142753.1 Arachidonic acid metabolism ION TRANSPORT BY P-TYPE ATPASES%REACTOME%R-RNO-936837.1 Ion transport by P-type ATPases PI-3K CASCADE:FGFR4%REACTOME%R-RNO-5654720.1 PI-3K cascade:FGFR4 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS%REACTOME DATABASE ID RELEASE 66%10144984 SLBP independent Processing of Histone Pre-mRNAs G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA%REACTOME%R-RNO-392451.1 G beta:gamma signalling through PI3Kgamma CLEC7A (DECTIN-1) SIGNALING%REACTOME%R-RNO-5607764.1 CLEC7A (Dectin-1) signaling CELL-EXTRACELLULAR MATRIX INTERACTIONS%REACTOME DATABASE ID RELEASE 66%10145642 Cell-extracellular matrix interactions SODIUM PROTON EXCHANGERS%REACTOME%R-RNO-425986.1 Sodium Proton exchangers INTERLEUKIN-7 SIGNALING%REACTOME%R-RNO-1266695.1 Interleukin-7 signaling ATTACHMENT OF GPI ANCHOR TO UPAR%REACTOME DATABASE ID RELEASE 66%10145107 Attachment of GPI anchor to uPAR ANTIGEN PROCESSING-CROSS PRESENTATION%REACTOME DATABASE ID RELEASE 66%10145813 Antigen processing-Cross presentation CALCITONIN-LIKE LIGAND RECEPTORS%REACTOME%R-RNO-419812.1 Calcitonin-like ligand receptors TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER%REACTOME%R-RNO-2173793.1 Transcriptional activity of SMAD2 SMAD3:SMAD4 heterotrimer P75NTR REGULATES AXONOGENESIS%REACTOME%R-RNO-193697.1 p75NTR regulates axonogenesis MET ACTIVATES PTPN11%REACTOME%R-RNO-8865999.1 MET activates PTPN11 RUNX1 AND FOXP3 CONTROL THE DEVELOPMENT OF REGULATORY T LYMPHOCYTES (TREGS)%REACTOME%R-RNO-8877330.1 RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) BILE ACID AND BILE SALT METABOLISM%REACTOME%R-RNO-194068.1 Bile acid and bile salt metabolism PREGNENOLONE BIOSYNTHESIS%REACTOME%R-RNO-196108.1 Pregnenolone biosynthesis CS DS DEGRADATION%REACTOME DATABASE ID RELEASE 66%10145885 CS DS degradation PI AND PC TRANSPORT BETWEEN ER AND GOLGI MEMBRANES%REACTOME%R-RNO-1483196.1 PI and PC transport between ER and Golgi membranes REELIN SIGNALLING PATHWAY%REACTOME DATABASE ID RELEASE 66%10146225 Reelin signalling pathway MRNA EDITING: A TO I CONVERSION%REACTOME%R-RNO-75064.1 mRNA Editing: A to I Conversion PHOSPHOLIPASE C-MEDIATED CASCADE; FGFR2%REACTOME DATABASE ID RELEASE 66%10146098 Phospholipase C-mediated cascade; FGFR2 MITOCHONDRIAL CALCIUM ION TRANSPORT%REACTOME%R-RNO-8949215.1 Mitochondrial calcium ion transport MITOCHONDRIAL ABC TRANSPORTERS%REACTOME%R-RNO-1369007.1 Mitochondrial ABC transporters TERMINATION OF TRANSLESION DNA SYNTHESIS%REACTOME DATABASE ID RELEASE 66%10146096 Termination of translesion DNA synthesis PEPTIDE HORMONE BIOSYNTHESIS%REACTOME%R-RNO-209952.1 Peptide hormone biosynthesis MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS%REACTOME%R-RNO-1362409.1 Mitochondrial iron-sulfur cluster biogenesis SEROTONIN NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 66%10145528 Serotonin Neurotransmitter Release Cycle LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATION FROM THE CENTROSOME%REACTOME%R-RNO-380284.1 Loss of proteins required for interphase microtubule organization from the centrosome LECTIN PATHWAY OF COMPLEMENT ACTIVATION%REACTOME%R-RNO-166662.1 Lectin pathway of complement activation FORMATION OF THE EARLY ELONGATION COMPLEX%REACTOME DATABASE ID RELEASE 66%10145012 Formation of the Early Elongation Complex PTK6 PROMOTES HIF1A STABILIZATION%REACTOME%R-RNO-8857538.1 PTK6 promotes HIF1A stabilization METABOLISM OF STEROID HORMONES%REACTOME DATABASE ID RELEASE 66%10145319 Metabolism of steroid hormones CHREBP ACTIVATES METABOLIC GENE EXPRESSION%REACTOME DATABASE ID RELEASE 66%10145124 ChREBP activates metabolic gene expression UREA CYCLE%REACTOME DATABASE ID RELEASE 66%10144786 Urea cycle MRNA EDITING%REACTOME%R-RNO-75072.1 mRNA Editing BETA OXIDATION OF LAUROYL-COA TO DECANOYL-COA-COA%REACTOME DATABASE ID RELEASE 66%10144931 Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA CASP8 ACTIVITY IS INHIBITED%REACTOME%R-RNO-5218900.1 CASP8 activity is inhibited PTK6 REGULATES CELL CYCLE%REACTOME DATABASE ID RELEASE 66%10146203 PTK6 Regulates Cell Cycle HYDROXYCARBOXYLIC ACID-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145664 Hydroxycarboxylic acid-binding receptors EFFECTS OF PIP2 HYDROLYSIS%REACTOME%R-RNO-114508.1 Effects of PIP2 hydrolysis UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A%REACTOME DATABASE ID RELEASE 66%10144752 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A SYNTHESIS OF PS%REACTOME%R-RNO-1483101.1 Synthesis of PS PHASE 4 - RESTING MEMBRANE POTENTIAL%REACTOME%R-RNO-5576886.1 Phase 4 - resting membrane potential NOTCH3 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME DATABASE ID RELEASE 66%10145951 NOTCH3 Activation and Transmission of Signal to the Nucleus BETA OXIDATION OF BUTANOYL-COA TO ACETYL-COA%REACTOME DATABASE ID RELEASE 66%10144935 Beta oxidation of butanoyl-CoA to acetyl-CoA UNWINDING OF DNA%REACTOME%R-RNO-176974.1 Unwinding of DNA PKB-MEDIATED EVENTS%REACTOME%R-RNO-109703.1 PKB-mediated events JOSEPHIN DOMAIN DUBS%REACTOME DATABASE ID RELEASE 66%10146138 Josephin domain DUBs HSP90 CHAPERONE CYCLE FOR SHRS%REACTOME DATABASE ID RELEASE 66%10146010 HSP90 chaperone cycle for SHRs NEUROFASCIN INTERACTIONS%REACTOME%R-RNO-447043.1 Neurofascin interactions COMPLEX I BIOGENESIS%REACTOME%R-RNO-6799198.1 Complex I biogenesis RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+%REACTOME%R-RNO-76005.1 Response to elevated platelet cytosolic Ca2+ GLUCONEOGENESIS%REACTOME%R-RNO-70263.1 Gluconeogenesis MAPK6 MAPK4 SIGNALING%REACTOME%R-RNO-5687128.1 MAPK6 MAPK4 signaling SIGNALING BY NUCLEAR RECEPTORS%REACTOME%R-RNO-9006931.1 Signaling by Nuclear Receptors ENOS ACTIVATION%REACTOME DATABASE ID RELEASE 66%10145394 eNOS activation GABA RECEPTOR ACTIVATION%REACTOME%R-RNO-977443.1 GABA receptor activation REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR%REACTOME DATABASE ID RELEASE 66%10145809 Regulation of gene expression by Hypoxia-inducible Factor STEROLS ARE 12-HYDROXYLATED BY CYP8B1%REACTOME%R-RNO-211994.1 Sterols are 12-hydroxylated by CYP8B1 WNT LIGAND BIOGENESIS AND TRAFFICKING%REACTOME%R-RNO-3238698.1 WNT ligand biogenesis and trafficking MET RECEPTOR ACTIVATION%REACTOME DATABASE ID RELEASE 66%10146172 MET Receptor Activation GPCR LIGAND BINDING%REACTOME DATABASE ID RELEASE 66%10145122 GPCR ligand binding TRIGLYCERIDE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 66%10144910 Triglyceride biosynthesis BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME%R-RNO-70895.1 Branched-chain amino acid catabolism NTRK2 ACTIVATES RAC1%REACTOME DATABASE ID RELEASE 66%10146322 NTRK2 activates RAC1 SIGNALING BY ERBB4%REACTOME%R-RNO-1236394.1 Signaling by ERBB4 DNA DAMAGE REVERSAL%REACTOME DATABASE ID RELEASE 66%10146231 DNA Damage Reversal DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX%REACTOME%R-RNO-3769402.1 Deactivation of the beta-catenin transactivating complex RECRUITMENT AND ATM-MEDIATED PHOSPHORYLATION OF REPAIR AND SIGNALING PROTEINS AT DNA DOUBLE STRAND BREAKS%REACTOME DATABASE ID RELEASE 66%10144760 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE%REACTOME%R-RNO-168179.1 Toll Like Receptor TLR1:TLR2 Cascade HEDGEHOG 'OFF' STATE%REACTOME%R-RNO-5610787.1 Hedgehog 'off' state APC-CDC20 MEDIATED DEGRADATION OF NEK2A%REACTOME DATABASE ID RELEASE 66%10145263 APC-Cdc20 mediated degradation of Nek2A NFG AND PRONGF BINDS TO P75NTR%REACTOME%R-RNO-205017.1 NFG and proNGF binds to p75NTR TRANSCRIPTIONAL ACTIVATION OF CELL CYCLE INHIBITOR P21%REACTOME DATABASE ID RELEASE 66%10146177 Transcriptional activation of cell cycle inhibitor p21 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS%REACTOME%R-RNO-416993.1 Trafficking of GluR2-containing AMPA receptors PROLINE CATABOLISM%REACTOME DATABASE ID RELEASE 66%10144794 Proline catabolism DEGRADATION OF GLI1 BY THE PROTEASOME%REACTOME DATABASE ID RELEASE 66%10146077 Degradation of GLI1 by the proteasome BETA OXIDATION OF DECANOYL-COA TO OCTANOYL-COA-COA%REACTOME%R-RNO-77346.1 Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA MMR%REACTOME%R-RNO-5358508.1 MMR POST-TRANSCRIPTIONAL SILENCING BY SMALL RNAS%REACTOME DATABASE ID RELEASE 66%10145622 Post-transcriptional silencing by small RNAs PI METABOLISM%REACTOME DATABASE ID RELEASE 66%10145378 PI Metabolism NEGATIVE REGULATION OF FGFR4 SIGNALING%REACTOME%R-RNO-5654733.1 Negative regulation of FGFR4 signaling NUCLEOBASE CATABOLISM%REACTOME%R-RNO-8956319.1 Nucleobase catabolism CROSS-PRESENTATION OF PARTICULATE EXOGENOUS ANTIGENS (PHAGOSOMES)%REACTOME%R-RNO-1236973.1 Cross-presentation of particulate exogenous antigens (phagosomes) MEIOSIS%REACTOME%R-RNO-1500620.1 Meiosis AKT-MEDIATED INACTIVATION OF FOXO1A%REACTOME DATABASE ID RELEASE 66%10145436 AKT-mediated inactivation of FOXO1A CREB PHOSPHORYLATION%REACTOME%R-RNO-199920.1 CREB phosphorylation RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN INTERLEUKIN SIGNALING%REACTOME DATABASE ID RELEASE 66%10146268 RUNX1 regulates transcription of genes involved in interleukin signaling SDK INTERACTIONS%REACTOME%R-RNO-373756.1 SDK interactions XENOBIOTICS%REACTOME DATABASE ID RELEASE 66%10144919 Xenobiotics SIGNALING PATHWAYS%REACTOME%R-RNO-162582.1 Signaling Pathways TRAF6 MEDIATED IRF7 ACTIVATION%REACTOME DATABASE ID RELEASE 66%10145758 TRAF6 mediated IRF7 activation NEUROTRANSMITTER RECEPTORS AND POSTSYNAPTIC SIGNAL TRANSMISSION%REACTOME%R-RNO-112314.1 Neurotransmitter receptors and postsynaptic signal transmission PLASMALOGEN BIOSYNTHESIS%REACTOME%R-RNO-75896.1 Plasmalogen biosynthesis TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING%REACTOME%R-RNO-975110.1 TRAF6 mediated IRF7 activation in TLR7 8 or 9 signaling ABACAVIR TRANSMEMBRANE TRANSPORT%REACTOME%R-RNO-2161517.1 Abacavir transmembrane transport RNA POLYMERASE I PROMOTER CLEARANCE%REACTOME%R-RNO-73854.1 RNA Polymerase I Promoter Clearance FCERI MEDIATED NF-KB ACTIVATION%REACTOME%R-RNO-2871837.1 FCERI mediated NF-kB activation THE AIM2 INFLAMMASOME%REACTOME%R-RNO-844615.1 The AIM2 inflammasome FORMATION OF RNA POL II ELONGATION COMPLEX%REACTOME%R-RNO-112382.1 Formation of RNA Pol II elongation complex NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%R-RNO-427413.1 NoRC negatively regulates rRNA expression FGFR3C LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 66%10145291 FGFR3c ligand binding and activation FATTY ACID METABOLISM%REACTOME%R-RNO-8978868.1 Fatty acid metabolism TNF RECEPTOR SUPERFAMILY (TNFSF) MEMBERS MEDIATING NON-CANONICAL NF-KB PATHWAY%REACTOME DATABASE ID RELEASE 66%10145372 TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway VEGFR2 MEDIATED VASCULAR PERMEABILITY%REACTOME%R-RNO-5218920.1 VEGFR2 mediated vascular permeability PI5P, PP2A AND IER3 REGULATE PI3K AKT SIGNALING%REACTOME%R-RNO-6811558.1 PI5P, PP2A and IER3 Regulate PI3K AKT Signaling FGFR1 LIGAND BINDING AND ACTIVATION%REACTOME%R-RNO-190242.1 FGFR1 ligand binding and activation SYNTHESIS OF PIPS AT THE ER MEMBRANE%REACTOME DATABASE ID RELEASE 66%10145900 Synthesis of PIPs at the ER membrane RHO GTPASES ACTIVATE IQGAPS%REACTOME DATABASE ID RELEASE 66%10146088 RHO GTPases activate IQGAPs RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 66%10145527 Recruitment of NuMA to mitotic centrosomes GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION%REACTOME%R-RNO-163841.1 Gamma carboxylation, hypusine formation and arylsulfatase activation GLYCINE DEGRADATION%REACTOME DATABASE ID RELEASE 66%10146148 Glycine degradation TANDEM PORE DOMAIN POTASSIUM CHANNELS%REACTOME DATABASE ID RELEASE 66%10145839 Tandem pore domain potassium channels DEGRADATION OF THE EXTRACELLULAR MATRIX%REACTOME%R-RNO-1474228.1 Degradation of the extracellular matrix ACYL CHAIN REMODELLING OF PG%REACTOME DATABASE ID RELEASE 66%10145863 Acyl chain remodelling of PG ACYL CHAIN REMODELING OF DAG AND TAG%REACTOME%R-RNO-1482883.1 Acyl chain remodeling of DAG and TAG NUCLEAR ENVELOPE BREAKDOWN%REACTOME DATABASE ID RELEASE 66%10145982 Nuclear Envelope Breakdown APC:CDC20 MEDIATED DEGRADATION OF CELL CYCLE PROTEINS PRIOR TO SATISFATION OF THE CELL CYCLE CHECKPOINT%REACTOME%R-RNO-179419.1 APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC%REACTOME DATABASE ID RELEASE 66%10145414 Antigen Presentation: Folding, assembly and peptide loading of class I MHC BLOCH PATHWAY%REACTOME%R-RNO-6807047.1 Bloch pathway RNA POLYMERASE I PROMOTER ESCAPE%REACTOME%R-RNO-73772.1 RNA Polymerase I Promoter Escape HDR THROUGH MMEJ (ALT-NHEJ)%REACTOME DATABASE ID RELEASE 66%10146137 HDR through MMEJ (alt-NHEJ) ALPHA-DEFENSINS%REACTOME%R-RNO-1462054.1 Alpha-defensins TOLL LIKE RECEPTOR 3 (TLR3) CASCADE%REACTOME DATABASE ID RELEASE 66%10145161 Toll Like Receptor 3 (TLR3) Cascade MET INTERACTS WITH TNS PROTEINS%REACTOME DATABASE ID RELEASE 66%10146251 MET interacts with TNS proteins INTERFERON GAMMA SIGNALING%REACTOME%R-RNO-877300.1 Interferon gamma signaling MAJOR PATHWAY OF RRNA PROCESSING IN THE NUCLEOLUS AND CYTOSOL%REACTOME%R-RNO-6791226.1 Major pathway of rRNA processing in the nucleolus and cytosol MET ACTIVATES STAT3%REACTOME%R-RNO-8875791.1 MET activates STAT3 ERYTHROCYTES TAKE UP CARBON DIOXIDE AND RELEASE OXYGEN%REACTOME DATABASE ID RELEASE 66%10145817 Erythrocytes take up carbon dioxide and release oxygen RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN BCR SIGNALING%REACTOME DATABASE ID RELEASE 66%10146269 RUNX1 regulates transcription of genes involved in BCR signaling G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%R-RNO-1296059.1 G protein gated Potassium channels CLEARANCE OF SERATONIN%REACTOME%R-RNO-380615.1 Clearance of seratonin MITOTIC PROMETAPHASE%REACTOME DATABASE ID RELEASE 66%10145506 Mitotic Prometaphase PLATELET SENSITIZATION BY LDL%REACTOME DATABASE ID RELEASE 66%10145634 Platelet sensitization by LDL REGULATION OF RUNX2 EXPRESSION AND ACTIVITY%REACTOME%R-RNO-8939902.1 Regulation of RUNX2 expression and activity RAB GERANYLGERANYLATION%REACTOME%R-RNO-8873719.1 RAB geranylgeranylation NEUROTRANSMITTER UPTAKE AND METABOLISM IN GLIAL CELLS%REACTOME%R-RNO-112313.1 Neurotransmitter uptake and metabolism In glial cells RAB GEFS EXCHANGE GTP FOR GDP ON RABS%REACTOME%R-RNO-8876198.1 RAB GEFs exchange GTP for GDP on RABs PRESYNAPTIC DEPOLARIZATION AND CALCIUM CHANNEL OPENING%REACTOME%R-RNO-112308.1 Presynaptic depolarization and calcium channel opening RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING%REACTOME DATABASE ID RELEASE 66%10144894 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening HISTIDINE CATABOLISM%REACTOME%R-RNO-70921.1 Histidine catabolism SIGNALING BY HIPPO%REACTOME DATABASE ID RELEASE 66%10145927 Signaling by Hippo RIBOSOMAL SCANNING AND START CODON RECOGNITION%REACTOME DATABASE ID RELEASE 66%10144836 Ribosomal scanning and start codon recognition PLATELET AGGREGATION (PLUG FORMATION)%REACTOME DATABASE ID RELEASE 66%10145477 Platelet Aggregation (Plug Formation) HEME BIOSYNTHESIS%REACTOME%R-RNO-189451.1 Heme biosynthesis NOD1 2 SIGNALING PATHWAY%REACTOME%R-RNO-168638.1 NOD1 2 Signaling Pathway INTERLEUKIN-4 AND INTERLEUKIN-13 SIGNALING%REACTOME%R-RNO-6785807.1 Interleukin-4 and Interleukin-13 signaling RELAXIN RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145665 Relaxin receptors ORGANIC CATION ANION ZWITTERION TRANSPORT%REACTOME%R-RNO-549132.1 Organic cation anion zwitterion transport CARNITINE SYNTHESIS%REACTOME DATABASE ID RELEASE 66%10144812 Carnitine synthesis CAM-PDE 1 ACTIVATION%REACTOME DATABASE ID RELEASE 66%10145008 Cam-PDE 1 activation HDR THROUGH SINGLE STRAND ANNEALING (SSA)%REACTOME DATABASE ID RELEASE 66%10144912 HDR through Single Strand Annealing (SSA) FASL CD95L SIGNALING%REACTOME%R-RNO-75157.1 FasL CD95L signaling SUMO IS PROTEOLYTICALLY PROCESSED%REACTOME%R-RNO-3065679.1 SUMO is proteolytically processed MAP2K AND MAPK ACTIVATION%REACTOME%R-RNO-5674135.1 MAP2K and MAPK activation ACTIVATION OF RAS IN B CELLS%REACTOME%R-RNO-1169092.1 Activation of RAS in B cells SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1%REACTOME DATABASE ID RELEASE 66%10145226 SCF-beta-TrCP mediated degradation of Emi1 ETHANOL OXIDATION%REACTOME DATABASE ID RELEASE 66%10144819 Ethanol oxidation RHO GTPASES REGULATE CFTR TRAFFICKING%REACTOME DATABASE ID RELEASE 66%10146090 RHO GTPases regulate CFTR trafficking FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF)%REACTOME DATABASE ID RELEASE 66%10146023 Formation of Senescence-Associated Heterochromatin Foci (SAHF) GOLGI-TO-ER RETROGRADE TRANSPORT%REACTOME%R-RNO-8856688.1 Golgi-to-ER retrograde transport REGULATION OF TP53 ACTIVITY THROUGH METHYLATION%REACTOME DATABASE ID RELEASE 66%10146002 Regulation of TP53 Activity through Methylation RESPIRATORY ELECTRON TRANSPORT%REACTOME%R-RNO-611105.1 Respiratory electron transport REVERSIBLE HYDRATION OF CARBON DIOXIDE%REACTOME%R-RNO-1475029.1 Reversible hydration of carbon dioxide SENSING OF DNA DOUBLE STRAND BREAKS%REACTOME%R-RNO-5693548.1 Sensing of DNA Double Strand Breaks NOSIP MEDIATED ENOS TRAFFICKING%REACTOME DATABASE ID RELEASE 66%10145408 NOSIP mediated eNOS trafficking BIOSYNTHESIS OF PROTECTIN AND RESOLVIN CONJUGATES IN TISSUE REGENERATION (PCTR AND RCTR)%REACTOME%R-RNO-9026766.1 Biosynthesis of protectin and resolvin conjugates in tissue regeneration (PCTR and RCTR) COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES%REACTOME%R-RNO-1650814.1 Collagen biosynthesis and modifying enzymes CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6%REACTOME%R-RNO-69017.1 CDK-mediated phosphorylation and removal of Cdc6 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24-HYDROXYCHOLESTEROL%REACTOME%R-RNO-193775.1 Synthesis of bile acids and bile salts via 24-hydroxycholesterol RUNX3 REGULATES CDKN1A TRANSCRIPTION%REACTOME%R-RNO-8941855.1 RUNX3 regulates CDKN1A transcription INTERLEUKIN-6 FAMILY SIGNALING%REACTOME%R-RNO-6783589.1 Interleukin-6 family signaling NA+ CL- DEPENDENT NEUROTRANSMITTER TRANSPORTERS%REACTOME%R-RNO-442660.1 Na+ Cl- dependent neurotransmitter transporters REGULATION OF MITOTIC CELL CYCLE%REACTOME%R-RNO-453276.1 Regulation of mitotic cell cycle ERKS ARE INACTIVATED%REACTOME DATABASE ID RELEASE 66%10145380 ERKs are inactivated PRE-NOTCH TRANSCRIPTION AND TRANSLATION%REACTOME DATABASE ID RELEASE 66%10146305 Pre-NOTCH Transcription and Translation VITAMIN B2 (RIBOFLAVIN) METABOLISM%REACTOME DATABASE ID RELEASE 66%10145350 Vitamin B2 (riboflavin) metabolism STABILIZATION OF P53%REACTOME%R-RNO-69541.1 Stabilization of p53 RESPONSE TO METAL IONS%REACTOME DATABASE ID RELEASE 66%10146118 Response to metal ions HYALURONAN METABOLISM%REACTOME%R-RNO-2142845.1 Hyaluronan metabolism ACTIVATION OF NA-PERMEABLE KAINATE RECEPTORS%REACTOME%R-RNO-451307.1 Activation of Na-permeable kainate receptors ELEVATION OF CYTOSOLIC CA2+ LEVELS%REACTOME%R-RNO-139853.1 Elevation of cytosolic Ca2+ levels TRANSLESION SYNTHESIS BY POLI%REACTOME DATABASE ID RELEASE 66%10146112 Translesion synthesis by POLI CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES)%REACTOME DATABASE ID RELEASE 66%10145812 Cross-presentation of soluble exogenous antigens (endosomes) GALACTOSE CATABOLISM%REACTOME DATABASE ID RELEASE 66%10144777 Galactose catabolism ERK MAPK TARGETS%REACTOME DATABASE ID RELEASE 66%10145363 ERK MAPK targets TRANSPORT OF GAMMA-CARBOXYLATED PROTEIN PRECURSORS FROM THE ENDOPLASMIC RETICULUM TO THE GOLGI APPARATUS%REACTOME%R-RNO-159763.1 Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus FORMATION OF TC-NER PRE-INCISION COMPLEX%REACTOME DATABASE ID RELEASE 66%10146151 Formation of TC-NER Pre-Incision Complex EICOSANOIDS%REACTOME%R-RNO-211979.1 Eicosanoids MRNA CAPPING%REACTOME DATABASE ID RELEASE 66%10144929 mRNA Capping MITOTIC SPINDLE CHECKPOINT%REACTOME DATABASE ID RELEASE 66%10145064 Mitotic Spindle Checkpoint SYNTHESIS OF HEPOXILINS (HX) AND TRIOXILINS (TRX)%REACTOME%R-RNO-2142696.1 Synthesis of Hepoxilins (HX) and Trioxilins (TrX) P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME%R-RNO-69613.1 p53-Independent G1 S DNA damage checkpoint SHC1 EVENTS IN ERBB2 SIGNALING%REACTOME DATABASE ID RELEASE 66%10145824 SHC1 events in ERBB2 signaling ACTIVATION OF MATRIX METALLOPROTEINASES%REACTOME%R-RNO-1592389.1 Activation of Matrix Metalloproteinases TANDEM OF PORE DOMAIN IN A WEAK INWARDLY RECTIFYING K+ CHANNELS (TWIK)%REACTOME DATABASE ID RELEASE 66%10145844 Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK) FRUCTOSE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 66%10146095 Fructose biosynthesis TRANSLOCATION OF ZAP-70 TO IMMUNOLOGICAL SYNAPSE%REACTOME DATABASE ID RELEASE 66%10145399 Translocation of ZAP-70 to Immunological synapse BIOSYNTHESIS OF DPAN-3-DERIVED PROTECTINS AND RESOLVINS%REACTOME%R-RNO-9026286.1 Biosynthesis of DPAn-3-derived protectins and resolvins REGULATION OF APOPTOSIS%REACTOME DATABASE ID RELEASE 66%10146243 Regulation of Apoptosis SYNTHESIS OF (16-20)-HYDROXYEICOSATETRAENOIC ACIDS (HETE)%REACTOME%R-RNO-2142816.1 Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) KERATAN SULFATE KERATIN METABOLISM%REACTOME DATABASE ID RELEASE 66%10145729 Keratan sulfate keratin metabolism CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A%REACTOME DATABASE ID RELEASE 66%10145216 Cdc20:Phospho-APC C mediated degradation of Cyclin A LDL CLEARANCE%REACTOME%R-RNO-8964038.1 LDL clearance TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX%REACTOME%R-RNO-445989.1 TAK1 activates NFkB by phosphorylation and activation of IKKs complex CHEMOKINE RECEPTORS BIND CHEMOKINES%REACTOME%R-RNO-380108.1 Chemokine receptors bind chemokines AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL%REACTOME%R-RNO-198323.1 AKT phosphorylates targets in the cytosol PROCESSING OF DNA DOUBLE-STRAND BREAK ENDS%REACTOME DATABASE ID RELEASE 66%10146130 Processing of DNA double-strand break ends CARGO TRAFFICKING TO THE PERICILIARY MEMBRANE%REACTOME DATABASE ID RELEASE 66%10146079 Cargo trafficking to the periciliary membrane GLYCEROPHOSPHOLIPID BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 66%10144908 Glycerophospholipid biosynthesis NEUROPHILIN INTERACTIONS WITH VEGF AND VEGFR%REACTOME%R-RNO-194306.1 Neurophilin interactions with VEGF and VEGFR DNA REPLICATION PRE-INITIATION%REACTOME DATABASE ID RELEASE 66%10144714 DNA Replication Pre-Initiation PRESYNAPTIC FUNCTION OF KAINATE RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145706 Presynaptic function of Kainate receptors NADPH REGENERATION%REACTOME DATABASE ID RELEASE 66%10145547 NADPH regeneration KERATAN SULFATE DEGRADATION%REACTOME%R-RNO-2022857.1 Keratan sulfate degradation BIOSYNTHESIS OF D-SERIES RESOLVINS%REACTOME DATABASE ID RELEASE 66%10146303 Biosynthesis of D-series resolvins AMPLIFICATION OF SIGNAL FROM THE KINETOCHORES%REACTOME%R-RNO-141424.1 Amplification of signal from the kinetochores REGULATION OF INSULIN SECRETION%REACTOME DATABASE ID RELEASE 66%10145114 Regulation of insulin secretion INTERLEUKIN-23 SIGNALING%REACTOME%R-RNO-9020933.1 Interleukin-23 signaling CALCINEURIN ACTIVATES NFAT%REACTOME DATABASE ID RELEASE 66%10145926 Calcineurin activates NFAT RNA POLYMERASE I TRANSCRIPTION%REACTOME%R-RNO-73864.1 RNA Polymerase I Transcription SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS%REACTOME%R-RNO-75876.1 Synthesis of very long-chain fatty acyl-CoAs REGULATION OF COMPLEMENT CASCADE%REACTOME%R-RNO-977606.1 Regulation of Complement cascade MTORC1-MEDIATED SIGNALLING%REACTOME%R-RNO-166208.1 mTORC1-mediated signalling METABOLISM OF POLYAMINES%REACTOME%R-RNO-351202.1 Metabolism of polyamines G2 M CHECKPOINTS%REACTOME DATABASE ID RELEASE 66%10144759 G2 M Checkpoints ORGANIC CATION TRANSPORT%REACTOME%R-RNO-549127.1 Organic cation transport TRANSCRIPTIONAL ACTIVATION OF P53 RESPONSIVE GENES%REACTOME DATABASE ID RELEASE 66%10146178 Transcriptional activation of p53 responsive genes CREATION OF C4 AND C2 ACTIVATORS%REACTOME DATABASE ID RELEASE 66%10145209 Creation of C4 and C2 activators GLUCOSE METABOLISM%REACTOME%R-RNO-70326.1 Glucose metabolism INTERLEUKIN-27 SIGNALING%REACTOME%R-RNO-9020956.1 Interleukin-27 signaling TRANSCRIPTIONAL REGULATION BY THE AP-2 (TFAP2) FAMILY OF TRANSCRIPTION FACTORS%REACTOME%R-RNO-8864260.1 Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION)%REACTOME%R-RNO-2173791.1 TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) NEGATIVE REGULATION OF TCF-DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS%REACTOME DATABASE ID RELEASE 66%10146021 Negative regulation of TCF-dependent signaling by WNT ligand antagonists BETA OXIDATION OF OCTANOYL-COA TO HEXANOYL-COA%REACTOME DATABASE ID RELEASE 66%10144937 Beta oxidation of octanoyl-CoA to hexanoyl-CoA RAB REGULATION OF TRAFFICKING%REACTOME DATABASE ID RELEASE 66%10146223 Rab regulation of trafficking NEUREXINS AND NEUROLIGINS%REACTOME%R-RNO-6794361.1 Neurexins and neuroligins FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS%REACTOME%R-RNO-2029480.1 Fcgamma receptor (FCGR) dependent phagocytosis ENDOGENOUS STEROLS%REACTOME DATABASE ID RELEASE 66%10145314 Endogenous sterols SPRY REGULATION OF FGF SIGNALING%REACTOME DATABASE ID RELEASE 66%10145760 Spry regulation of FGF signaling ER-PHAGOSOME PATHWAY%REACTOME DATABASE ID RELEASE 66%10145816 ER-Phagosome pathway OTHER SEMAPHORIN INTERACTIONS%REACTOME%R-RNO-416700.1 Other semaphorin interactions SIGNALING BY BMP%REACTOME DATABASE ID RELEASE 66%10145385 Signaling by BMP NEGATIVE REGULATION OF FGFR2 SIGNALING%REACTOME DATABASE ID RELEASE 66%10145762 Negative regulation of FGFR2 signaling REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF)%REACTOME DATABASE ID RELEASE 66%10145896 Regulation of cholesterol biosynthesis by SREBP (SREBF) APOPTOSIS%REACTOME DATABASE ID RELEASE 66%10144862 Apoptosis DERMATAN SULFATE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 66%10145924 Dermatan sulfate biosynthesis CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION%REACTOME DATABASE ID RELEASE 66%10144735 Cyclin E associated events during G1 S transition BIOGENIC AMINES ARE OXIDATIVELY DEAMINATED TO ALDEHYDES BY MAOA AND MAOB%REACTOME DATABASE ID RELEASE 66%10145055 Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB TNF SIGNALING%REACTOME%R-RNO-75893.1 TNF signaling DIGESTION OF DIETARY CARBOHYDRATE%REACTOME%R-RNO-189085.1 Digestion of dietary carbohydrate PLATELET DEGRANULATION%REACTOME DATABASE ID RELEASE 66%10145469 Platelet degranulation PROGRAMMED CELL DEATH%REACTOME%R-RNO-5357801.1 Programmed Cell Death SIGNALING BY NOTCH2%REACTOME DATABASE ID RELEASE 66%10145921 Signaling by NOTCH2 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS)%REACTOME DATABASE ID RELEASE 66%10145487 Class A 1 (Rhodopsin-like receptors) TELOMERE C-STRAND SYNTHESIS INITIATION%REACTOME DATABASE ID RELEASE 66%10145233 Telomere C-strand synthesis initiation DCC MEDIATED ATTRACTIVE SIGNALING%REACTOME%R-RNO-418885.1 DCC mediated attractive signaling THE FATTY ACID CYCLING MODEL%REACTOME DATABASE ID RELEASE 66%10145135 The fatty acid cycling model SYNTHESIS OF UDP-N-ACETYL-GLUCOSAMINE%REACTOME%R-RNO-446210.1 Synthesis of UDP-N-acetyl-glucosamine HYALURONAN BIOSYNTHESIS AND EXPORT%REACTOME%R-RNO-2142850.1 Hyaluronan biosynthesis and export SMOOTH MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 66%10145669 Smooth Muscle Contraction DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX%REACTOME%R-RNO-195253.1 Degradation of beta-catenin by the destruction complex POLO-LIKE KINASE MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 66%10145073 Polo-like kinase mediated events SYNTHESIS OF 12-EICOSATETRAENOIC ACID DERIVATIVES%REACTOME DATABASE ID RELEASE 66%10145948 Synthesis of 12-eicosatetraenoic acid derivatives BETAKLOTHO-MEDIATED LIGAND BINDING%REACTOME%R-RNO-1307965.1 betaKlotho-mediated ligand binding CYCLIN D ASSOCIATED EVENTS IN G1%REACTOME DATABASE ID RELEASE 66%10144736 Cyclin D associated events in G1 DNA DOUBLE-STRAND BREAK REPAIR%REACTOME DATABASE ID RELEASE 66%10144762 DNA Double-Strand Break Repair NICOTINATE METABOLISM%REACTOME%R-RNO-196807.1 Nicotinate metabolism ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS%REACTOME DATABASE ID RELEASE 66%10145788 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION)%REACTOME%R-RNO-70614.1 Amino acid synthesis and interconversion (transamination) TRANSPORT OF ORGANIC ANIONS%REACTOME DATABASE ID RELEASE 66%10145337 Transport of organic anions NIK-->NONCANONICAL NF-KB SIGNALING%REACTOME DATABASE ID RELEASE 66%10146074 NIK-->noncanonical NF-kB signaling HISTAMINE RECEPTORS%REACTOME%R-RNO-390650.1 Histamine receptors SHC-MEDIATED CASCADE:FGFR4%REACTOME%R-RNO-5654719.1 SHC-mediated cascade:FGFR4 APEX1-INDEPENDENT RESOLUTION OF AP SITES VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 66%10146092 APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway UNFOLDED PROTEIN RESPONSE (UPR)%REACTOME DATABASE ID RELEASE 66%10145530 Unfolded Protein Response (UPR) STIMULI-SENSING CHANNELS%REACTOME%R-RNO-2672351.1 Stimuli-sensing channels GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS)%REACTOME DATABASE ID RELEASE 66%10144780 Glycogen breakdown (glycogenolysis) B CELL ACTIVATION%REACTOME DATABASE ID RELEASE 66%10145789 B Cell Activation PTK6 REGULATES RHO GTPASES, RAS GTPASE AND MAP KINASES%REACTOME DATABASE ID RELEASE 66%10146205 PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases EPH-EPHRIN SIGNALING%REACTOME DATABASE ID RELEASE 66%10146025 EPH-Ephrin signaling TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN CYTOCHROME C RELEASE%REACTOME%R-RNO-6803204.1 TP53 Regulates Transcription of Genes Involved in Cytochrome C Release POLYMERASE SWITCHING%REACTOME DATABASE ID RELEASE 66%10144729 Polymerase switching PERK REGULATES GENE EXPRESSION%REACTOME DATABASE ID RELEASE 66%10145531 PERK regulates gene expression REGULATION OF RUNX3 EXPRESSION AND ACTIVITY%REACTOME%R-RNO-8941858.1 Regulation of RUNX3 expression and activity LIGAND-RECEPTOR INTERACTIONS%REACTOME DATABASE ID RELEASE 66%10145666 Ligand-receptor interactions PLATELET HOMEOSTASIS%REACTOME DATABASE ID RELEASE 66%10145040 Platelet homeostasis CLASSICAL ANTIBODY-MEDIATED COMPLEMENT ACTIVATION%REACTOME%R-RNO-173623.1 Classical antibody-mediated complement activation ZINC TRANSPORTERS%REACTOME DATABASE ID RELEASE 66%10145654 Zinc transporters TRANSCRIPTIONAL REGULATION BY SMALL RNAS%REACTOME DATABASE ID RELEASE 66%10146071 Transcriptional regulation by small RNAs INTERFERON SIGNALING%REACTOME%R-RNO-913531.1 Interferon Signaling IRS ACTIVATION%REACTOME DATABASE ID RELEASE 66%10144874 IRS activation BUTYROPHILIN (BTN) FAMILY INTERACTIONS%REACTOME%R-RNO-8851680.1 Butyrophilin (BTN) family interactions NUCLEOTIDE SALVAGE%REACTOME%R-RNO-8956321.1 Nucleotide salvage COENZYME A BIOSYNTHESIS%REACTOME%R-RNO-196783.1 Coenzyme A biosynthesis TRANSLESION SYNTHESIS BY POLK%REACTOME DATABASE ID RELEASE 66%10146111 Translesion synthesis by POLK KERATINIZATION%REACTOME%R-RNO-6805567.1 Keratinization MRNA 3'-END PROCESSING%REACTOME DATABASE ID RELEASE 66%10144830 mRNA 3'-end processing MITOCHONDRIAL BIOGENESIS%REACTOME DATABASE ID RELEASE 66%10145879 Mitochondrial biogenesis RIP-MEDIATED NFKB ACTIVATION VIA ZBP1%REACTOME%R-RNO-1810476.1 RIP-mediated NFkB activation via ZBP1 TWIK-RELEATED ACID-SENSITIVE K+ CHANNEL (TASK)%REACTOME DATABASE ID RELEASE 66%10145845 TWIK-releated acid-sensitive K+ channel (TASK) FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX%REACTOME DATABASE ID RELEASE 66%10144838 Formation of the ternary complex, and subsequently, the 43S complex GLYCOGEN SYNTHESIS%REACTOME%R-RNO-3322077.1 Glycogen synthesis IRAK1 RECRUITS IKK COMPLEX%REACTOME DATABASE ID RELEASE 66%10145768 IRAK1 recruits IKK complex G2 M DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 66%10144758 G2 M DNA damage checkpoint SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%R-RNO-427359.1 SIRT1 negatively regulates rRNA expression CONDENSATION OF PROMETAPHASE CHROMOSOMES%REACTOME DATABASE ID RELEASE 66%10145973 Condensation of Prometaphase Chromosomes NEGATIVE REGULATION OF FGFR3 SIGNALING%REACTOME%R-RNO-5654732.1 Negative regulation of FGFR3 signaling NEDDYLATION%REACTOME DATABASE ID RELEASE 66%10146142 Neddylation ORGANELLE BIOGENESIS AND MAINTENANCE%REACTOME DATABASE ID RELEASE 66%10145880 Organelle biogenesis and maintenance P53-INDEPENDENT DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 66%10144753 p53-Independent DNA Damage Response TFAP2 (AP-2) FAMILY REGULATES TRANSCRIPTION OF CELL CYCLE FACTORS%REACTOME%R-RNO-8866911.1 TFAP2 (AP-2) family regulates transcription of cell cycle factors REGULATION OF IFNG SIGNALING%REACTOME DATABASE ID RELEASE 66%10145739 Regulation of IFNG signaling FGFR1C LIGAND BINDING AND ACTIVATION%REACTOME%R-RNO-190373.1 FGFR1c ligand binding and activation REGULATION OF RAS BY GAPS%REACTOME%R-RNO-5658442.1 Regulation of RAS by GAPs RETROGRADE TRANSPORT AT THE TRANS-GOLGI-NETWORK%REACTOME%R-RNO-6811440.1 Retrograde transport at the Trans-Golgi-Network TRANSLOCATION OF SLC2A4 (GLUT4) TO THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 66%10145854 Translocation of SLC2A4 (GLUT4) to the plasma membrane ACTIVATION OF NMDA RECEPTORS AND POSTSYNAPTIC EVENTS%REACTOME%R-RNO-442755.1 Activation of NMDA receptors and postsynaptic events INTERACTION WITH CUMULUS CELLS%REACTOME DATABASE ID RELEASE 66%10145974 Interaction With Cumulus Cells INTERLEUKIN-9 SIGNALING%REACTOME%R-RNO-8985947.1 Interleukin-9 signaling SIGNALING BY NOTCH%REACTOME DATABASE ID RELEASE 66%10145914 Signaling by NOTCH SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE%REACTOME DATABASE ID RELEASE 66%10144727 Switching of origins to a post-replicative state SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA-HYDROXYCHOLESTEROL%REACTOME DATABASE ID RELEASE 66%10145313 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 66%10145498 Semaphorin interactions CREATINE METABOLISM%REACTOME DATABASE ID RELEASE 66%10144813 Creatine metabolism PHOSPHORYLATION OF PROTEINS INVOLVED IN G1 S TRANSITION BY ACTIVE CYCLIN E:CDK2 COMPLEXES%REACTOME DATABASE ID RELEASE 66%10145275 Phosphorylation of proteins involved in G1 S transition by active Cyclin E:Cdk2 complexes INTRINSIC PATHWAY OF FIBRIN CLOT FORMATION%REACTOME DATABASE ID RELEASE 66%10145080 Intrinsic Pathway of Fibrin Clot Formation RUNX1 INTERACTS WITH CO-FACTORS WHOSE PRECISE EFFECT ON RUNX1 TARGETS IS NOT KNOWN%REACTOME%R-RNO-8939243.1 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known SUMO IS TRANSFERRED FROM E1 TO E2 (UBE2I, UBC9)%REACTOME DATABASE ID RELEASE 66%10145988 SUMO is transferred from E1 to E2 (UBE2I, UBC9) VITAMIN D (CALCIFEROL) METABOLISM%REACTOME%R-RNO-196791.1 Vitamin D (calciferol) metabolism ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM%REACTOME%R-RNO-2046104.1 alpha-linolenic (omega3) and linoleic (omega6) acid metabolism KERATAN SULFATE BIOSYNTHESIS%REACTOME%R-RNO-2022854.1 Keratan sulfate biosynthesis ACTIVATION OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 66%10144723 Activation of the pre-replicative complex HCN CHANNELS%REACTOME%R-RNO-1296061.1 HCN channels SUMOYLATION OF DNA REPLICATION PROTEINS%REACTOME%R-RNO-4615885.1 SUMOylation of DNA replication proteins HEDGEHOG 'ON' STATE%REACTOME%R-RNO-5632684.1 Hedgehog 'on' state FRS2-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 66%10145200 Frs2-mediated activation G BETA:GAMMA SIGNALLING THROUGH PLC BETA%REACTOME DATABASE ID RELEASE 66%10145577 G beta:gamma signalling through PLC beta INHIBITION OF TSC COMPLEX FORMATION BY PKB%REACTOME%R-RNO-165181.1 Inhibition of TSC complex formation by PKB NEGATIVE REGULATION OF FGFR1 SIGNALING%REACTOME%R-RNO-5654726.1 Negative regulation of FGFR1 signaling PLASMA LIPOPROTEIN REMODELING%REACTOME%R-RNO-8963899.1 Plasma lipoprotein remodeling AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE%REACTOME%R-RNO-352230.1 Amino acid transport across the plasma membrane APOPTOSIS INDUCED DNA FRAGMENTATION%REACTOME DATABASE ID RELEASE 66%10145440 Apoptosis induced DNA fragmentation NF-KB IS ACTIVATED AND SIGNALS SURVIVAL%REACTOME%R-RNO-209560.1 NF-kB is activated and signals survival CELLULAR RESPONSE TO HEAT STRESS%REACTOME%R-RNO-3371556.1 Cellular response to heat stress TRANSPORT OF NUCLEOTIDE SUGARS%REACTOME%R-RNO-727802.1 Transport of nucleotide sugars SEPARATION OF SISTER CHROMATIDS%REACTOME DATABASE ID RELEASE 66%10145223 Separation of Sister Chromatids GAMMA-CARBOXYLATION OF PROTEIN PRECURSORS%REACTOME%R-RNO-159740.1 Gamma-carboxylation of protein precursors REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND%REACTOME DATABASE ID RELEASE 66%10145237 Removal of the Flap Intermediate from the C-strand SMAC-MEDIATED APOPTOTIC RESPONSE%REACTOME DATABASE ID RELEASE 66%10145021 SMAC-mediated apoptotic response PI-3K CASCADE:FGFR1%REACTOME%R-RNO-5654689.1 PI-3K cascade:FGFR1 METABOLISM OF COFACTORS%REACTOME DATABASE ID RELEASE 66%10145548 Metabolism of cofactors EUKARYOTIC TRANSLATION ELONGATION%REACTOME%R-RNO-156842.1 Eukaryotic Translation Elongation TELOMERE EXTENSION BY TELOMERASE%REACTOME DATABASE ID RELEASE 66%10145110 Telomere Extension By Telomerase SIGNALLING TO ERKS%REACTOME DATABASE ID RELEASE 66%10145182 Signalling to ERKs LAGGING STRAND SYNTHESIS%REACTOME%R-RNO-69186.1 Lagging Strand Synthesis POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS%REACTOME DATABASE ID RELEASE 66%10145102 Post-translational modification: synthesis of GPI-anchored proteins DIGESTION OF DIETARY LIPID%REACTOME%R-RNO-192456.1 Digestion of dietary lipid WNT5A-DEPENDENT INTERNALIZATION OF FZD4%REACTOME DATABASE ID RELEASE 66%10146042 WNT5A-dependent internalization of FZD4 COMMON PATHWAY OF FIBRIN CLOT FORMATION%REACTOME%R-RNO-140875.1 Common Pathway of Fibrin Clot Formation ACYL CHAIN REMODELLING OF PS%REACTOME DATABASE ID RELEASE 66%10145868 Acyl chain remodelling of PS ASSEMBLY OF THE ORC COMPLEX AT THE ORIGIN OF REPLICATION%REACTOME DATABASE ID RELEASE 66%10144712 Assembly of the ORC complex at the origin of replication HSF1 ACTIVATION%REACTOME%R-RNO-3371511.1 HSF1 activation NON-CODING RNA METABOLISM%REACTOME%R-RNO-194441.1 Non-coding RNA Metabolism REGULATION OF TP53 ACTIVITY THROUGH PHOSPHORYLATION%REACTOME DATABASE ID RELEASE 66%10144756 Regulation of TP53 Activity through Phosphorylation MITOCHONDRIAL TRANSLATION TERMINATION%REACTOME DATABASE ID RELEASE 66%10146065 Mitochondrial translation termination CONJUGATION OF CARBOXYLIC ACIDS%REACTOME DATABASE ID RELEASE 66%10145090 Conjugation of carboxylic acids OPSINS%REACTOME%R-RNO-419771.1 Opsins TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES%REACTOME DATABASE ID RELEASE 66%10144951 Transport of vitamins, nucleosides, and related molecules EICOSANOID LIGAND-BINDING RECEPTORS%REACTOME%R-RNO-391903.1 Eicosanoid ligand-binding receptors FRUCTOSE METABOLISM%REACTOME%R-RNO-5652084.1 Fructose metabolism B-WICH COMPLEX POSITIVELY REGULATES RRNA EXPRESSION%REACTOME DATABASE ID RELEASE 66%10146051 B-WICH complex positively regulates rRNA expression PCNA-DEPENDENT LONG PATCH BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 66%10144982 PCNA-Dependent Long Patch Base Excision Repair TNFS BIND THEIR PHYSIOLOGICAL RECEPTORS%REACTOME DATABASE ID RELEASE 66%10146122 TNFs bind their physiological receptors INTERLEUKIN-37 SIGNALING%REACTOME DATABASE ID RELEASE 66%10146292 Interleukin-37 signaling RETROGRADE NEUROTROPHIN SIGNALLING%REACTOME%R-RNO-177504.1 Retrograde neurotrophin signalling PRPP BIOSYNTHESIS%REACTOME%R-RNO-73843.1 PRPP biosynthesis RHO GTPASES ACTIVATE KTN1%REACTOME%R-RNO-5625970.1 RHO GTPases activate KTN1 PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS%REACTOME%R-RNO-202427.1 Phosphorylation of CD3 and TCR zeta chains ACTIVATION OF GABAB RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145188 Activation of GABAB receptors CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS%REACTOME%R-RNO-442742.1 CREB phosphorylation through the activation of Ras ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 66%10145158 Activation of the AP-1 family of transcription factors SYNTHESIS OF DOLICHYL-PHOSPHATE-GLUCOSE%REACTOME DATABASE ID RELEASE 66%10145673 Synthesis of dolichyl-phosphate-glucose PTK6 REGULATES RTKS AND THEIR EFFECTORS AKT1 AND DOK1%REACTOME DATABASE ID RELEASE 66%10146206 PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 COHESIN LOADING ONTO CHROMATIN%REACTOME%R-RNO-2470946.1 Cohesin Loading onto Chromatin SEMA3A PAK DEPENDENT AXON REPULSION%REACTOME DATABASE ID RELEASE 66%10145582 Sema3A PAK dependent Axon repulsion ATTENUATION PHASE%REACTOME DATABASE ID RELEASE 66%10146014 Attenuation phase RNA POLYMERASE II TRANSCRIPTION%REACTOME DATABASE ID RELEASE 66%10144750 RNA Polymerase II Transcription ROLE OF ABL IN ROBO-SLIT SIGNALING%REACTOME%R-RNO-428890.1 Role of ABL in ROBO-SLIT signaling SIGNALING BY FGFR3%REACTOME DATABASE ID RELEASE 66%10145259 Signaling by FGFR3 COLLAGEN FORMATION%REACTOME%R-RNO-1474290.1 Collagen formation DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION%REACTOME%R-RNO-3134963.1 DEx H-box helicases activate type I IFN and inflammatory cytokines production SUMOYLATION OF SUMOYLATION PROTEINS%REACTOME DATABASE ID RELEASE 66%10146029 SUMOylation of SUMOylation proteins REGULATED NECROSIS%REACTOME%R-RNO-5218859.1 Regulated Necrosis SYNTHESIS OF 15-EICOSATETRAENOIC ACID DERIVATIVES%REACTOME DATABASE ID RELEASE 66%10145944 Synthesis of 15-eicosatetraenoic acid derivatives EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA%REACTOME%R-RNO-212718.1 EGFR interacts with phospholipase C-gamma PHOSPHORYLATION OF EMI1%REACTOME DATABASE ID RELEASE 66%10145225 Phosphorylation of Emi1 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY%REACTOME%R-RNO-3301854.1 Nuclear Pore Complex (NPC) Disassembly REPRESSION OF WNT TARGET GENES%REACTOME DATABASE ID RELEASE 66%10146038 Repression of WNT target genes APOPTOTIC EXECUTION PHASE%REACTOME DATABASE ID RELEASE 66%10145388 Apoptotic execution phase RUNX3 REGULATES NOTCH SIGNALING%REACTOME%R-RNO-8941856.1 RUNX3 regulates NOTCH signaling VEGFR2 MEDIATED CELL PROLIFERATION%REACTOME DATABASE ID RELEASE 66%10146032 VEGFR2 mediated cell proliferation NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145596 Nucleotide-like (purinergic) receptors SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 27-HYDROXYCHOLESTEROL%REACTOME%R-RNO-193807.1 Synthesis of bile acids and bile salts via 27-hydroxycholesterol INTEGRIN SIGNALING%REACTOME DATABASE ID RELEASE 66%10145478 Integrin signaling G ALPHA (I) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 66%10144868 G alpha (i) signalling events TRANSMISSION ACROSS CHEMICAL SYNAPSES%REACTOME%R-RNO-112315.1 Transmission across Chemical Synapses FGFR2 LIGAND BINDING AND ACTIVATION%REACTOME%R-RNO-190241.1 FGFR2 ligand binding and activation SIGNALING BY NON-RECEPTOR TYROSINE KINASES%REACTOME DATABASE ID RELEASE 66%10146199 Signaling by Non-Receptor Tyrosine Kinases CARDIAC CONDUCTION%REACTOME%R-RNO-5576891.1 Cardiac conduction TBC RABGAPS%REACTOME DATABASE ID RELEASE 66%10146222 TBC RABGAPs FBXL7 DOWN-REGULATES AURKA DURING MITOTIC ENTRY AND IN EARLY MITOSIS%REACTOME%R-RNO-8854050.1 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis COPI-INDEPENDENT GOLGI-TO-ER RETROGRADE TRAFFIC%REACTOME%R-RNO-6811436.1 COPI-independent Golgi-to-ER retrograde traffic TANDEM PORE DOMAIN HALOTHANE-INHIBITED K+ CHANNEL (THIK)%REACTOME DATABASE ID RELEASE 66%10145843 Tandem pore domain halothane-inhibited K+ channel (THIK) PYROPHOSPHATE HYDROLYSIS%REACTOME%R-RNO-71737.1 Pyrophosphate hydrolysis MITOPHAGY%REACTOME DATABASE ID RELEASE 66%10146046 Mitophagy LYSOSOMAL OLIGOSACCHARIDE CATABOLISM%REACTOME DATABASE ID RELEASE 66%10146170 Lysosomal oligosaccharide catabolism POTASSIUM CHANNELS%REACTOME%R-RNO-1296071.1 Potassium Channels PI3K CASCADE%REACTOME DATABASE ID RELEASE 66%10144954 PI3K Cascade BREAKDOWN OF THE NUCLEAR LAMINA%REACTOME%R-RNO-352238.1 Breakdown of the nuclear lamina ACTIVATION, TRANSLOCATION AND OLIGOMERIZATION OF BAX%REACTOME DATABASE ID RELEASE 66%10145017 Activation, translocation and oligomerization of BAX ENDOSOMAL VACUOLAR PATHWAY%REACTOME%R-RNO-1236977.1 Endosomal Vacuolar pathway ABACAVIR METABOLISM%REACTOME%R-RNO-2161541.1 Abacavir metabolism PROTEIN FOLDING%REACTOME%R-RNO-391251.1 Protein folding ACTIVATION OF BIM AND TRANSLOCATION TO MITOCHONDRIA%REACTOME DATABASE ID RELEASE 66%10145048 Activation of BIM and translocation to mitochondria SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION%REACTOME%R-RNO-399955.1 SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion SIGNALING BY NTRKS%REACTOME%R-RNO-166520.1 Signaling by NTRKs HUR (ELAVL1) BINDS AND STABILIZES MRNA%REACTOME DATABASE ID RELEASE 66%10145693 HuR (ELAVL1) binds and stabilizes mRNA INTESTINAL LIPID ABSORPTION%REACTOME DATABASE ID RELEASE 66%10145460 Intestinal lipid absorption RNA POLYMERASE I PROMOTER OPENING%REACTOME DATABASE ID RELEASE 66%10144847 RNA Polymerase I Promoter Opening INTEGRIN CELL SURFACE INTERACTIONS%REACTOME%R-RNO-216083.1 Integrin cell surface interactions TNFR2 NON-CANONICAL NF-KB PATHWAY%REACTOME DATABASE ID RELEASE 66%10145373 TNFR2 non-canonical NF-kB pathway N-GLYCAN TRIMMING AND ELONGATION IN THE CIS-GOLGI%REACTOME DATABASE ID RELEASE 66%10145771 N-glycan trimming and elongation in the cis-Golgi FRS-MEDIATED FGFR4 SIGNALING%REACTOME DATABASE ID RELEASE 66%10146106 FRS-mediated FGFR4 signaling G-PROTEIN ACTIVATION%REACTOME%R-RNO-202040.1 G-protein activation OXIDATIVE STRESS INDUCED SENESCENCE%REACTOME DATABASE ID RELEASE 66%10145165 Oxidative Stress Induced Senescence TACHYKININ RECEPTORS BIND TACHYKININS%REACTOME DATABASE ID RELEASE 66%10145521 Tachykinin receptors bind tachykinins GLOBAL GENOME NUCLEOTIDE EXCISION REPAIR (GG-NER)%REACTOME%R-RNO-5696399.1 Global Genome Nucleotide Excision Repair (GG-NER) CENTROSOME MATURATION%REACTOME%R-RNO-380287.1 Centrosome maturation CHROMATIN ORGANIZATION%REACTOME DATABASE ID RELEASE 66%10145803 Chromatin organization EXTENSION OF TELOMERES%REACTOME DATABASE ID RELEASE 66%10145111 Extension of Telomeres CDO IN MYOGENESIS%REACTOME DATABASE ID RELEASE 66%10145503 CDO in myogenesis GAP JUNCTION TRAFFICKING AND REGULATION%REACTOME DATABASE ID RELEASE 66%10145298 Gap junction trafficking and regulation GLUTATHIONE SYNTHESIS AND RECYCLING%REACTOME%R-RNO-174403.1 Glutathione synthesis and recycling INTERLEUKIN-3, INTERLEUKIN-5 AND GM-CSF SIGNALING%REACTOME DATABASE ID RELEASE 66%10145705 Interleukin-3, Interleukin-5 and GM-CSF signaling ACYL CHAIN REMODELLING OF PC%REACTOME%R-RNO-1482788.1 Acyl chain remodelling of PC INTERLEUKIN-1 SIGNALING%REACTOME%R-RNO-9020702.1 Interleukin-1 signaling G0 AND EARLY G1%REACTOME%R-RNO-1538133.1 G0 and Early G1 ACTIVATION OF CAMK IV%REACTOME%R-RNO-442745.1 Activation of CaMK IV ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%R-RNO-1296041.1 Activation of G protein gated Potassium channels DUAL INCISION IN TC-NER%REACTOME%R-RNO-6782135.1 Dual incision in TC-NER CYTOSOLIC TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 66%10144822 Cytosolic tRNA aminoacylation ELECTRON TRANSPORT FROM NADPH TO FERREDOXIN%REACTOME%R-RNO-2395516.1 Electron transport from NADPH to Ferredoxin VEGF LIGAND-RECEPTOR INTERACTIONS%REACTOME DATABASE ID RELEASE 66%10145339 VEGF ligand-receptor interactions YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION%REACTOME%R-RNO-2032785.1 YAP1- and WWTR1 (TAZ)-stimulated gene expression DNA REPAIR%REACTOME DATABASE ID RELEASE 66%10144763 DNA Repair REGULATION OF NECROPTOTIC CELL DEATH%REACTOME DATABASE ID RELEASE 66%10146017 Regulation of necroptotic cell death INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1%REACTOME DATABASE ID RELEASE 66%10145013 Inhibition of replication initiation of damaged DNA by RB1 E2F1 RECOGNITION OF DNA DAMAGE BY PCNA-CONTAINING REPLICATION COMPLEX%REACTOME DATABASE ID RELEASE 66%10146094 Recognition of DNA damage by PCNA-containing replication complex SYNAPTIC ADHESION-LIKE MOLECULES%REACTOME DATABASE ID RELEASE 66%10146209 Synaptic adhesion-like molecules VEGF BINDS TO VEGFR LEADING TO RECEPTOR DIMERIZATION%REACTOME DATABASE ID RELEASE 66%10145338 VEGF binds to VEGFR leading to receptor dimerization THE ACTIVATION OF ARYLSULFATASES%REACTOME DATABASE ID RELEASE 66%10145887 The activation of arylsulfatases LINOLEIC ACID (LA) METABOLISM%REACTOME DATABASE ID RELEASE 66%10145933 Linoleic acid (LA) metabolism FORMATION OF ANNULAR GAP JUNCTIONS%REACTOME%R-RNO-196025.1 Formation of annular gap junctions CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM%REACTOME DATABASE ID RELEASE 66%10145886 Chondroitin sulfate dermatan sulfate metabolism INTERLEUKIN-12 FAMILY SIGNALING%REACTOME%R-RNO-447115.1 Interleukin-12 family signaling TOLL LIKE RECEPTOR 10 (TLR10) CASCADE%REACTOME%R-RNO-168142.1 Toll Like Receptor 10 (TLR10) Cascade BIOSYNTHESIS OF ASPIRIN-TRIGGERED D-SERIES RESOLVINS%REACTOME%R-RNO-9020265.1 Biosynthesis of aspirin-triggered D-series resolvins ADENYLATE CYCLASE INHIBITORY PATHWAY%REACTOME DATABASE ID RELEASE 66%10145186 Adenylate cyclase inhibitory pathway HYDROLYSIS OF LPC%REACTOME%R-RNO-1483115.1 Hydrolysis of LPC PRE-NOTCH EXPRESSION AND PROCESSING%REACTOME DATABASE ID RELEASE 66%10145916 Pre-NOTCH Expression and Processing CD22 MEDIATED BCR REGULATION%REACTOME DATABASE ID RELEASE 66%10146141 CD22 mediated BCR regulation ACTIVATION OF NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%R-RNO-629602.1 Activation of Nicotinic Acetylcholine Receptors TRANSCRIPTION FROM MITOCHONDRIAL PROMOTERS%REACTOME DATABASE ID RELEASE 66%10145118 Transcription from mitochondrial promoters DOPAMINE RECEPTORS%REACTOME%R-RNO-390651.1 Dopamine receptors SYNTHESIS OF EPOXY (EET) AND DIHYDROXYEICOSATRIENOIC ACIDS (DHET)%REACTOME DATABASE ID RELEASE 66%10145947 Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK%REACTOME DATABASE ID RELEASE 66%10145383 Energy dependent regulation of mTOR by LKB1-AMPK BIOSYNTHESIS OF E-SERIES 18(S)-RESOLVINS%REACTOME%R-RNO-9018896.1 Biosynthesis of E-series 18(S)-resolvins SYNTHESIS OF PA%REACTOME DATABASE ID RELEASE 66%10144907 Synthesis of PA NOSTRIN MEDIATED ENOS TRAFFICKING%REACTOME%R-RNO-203641.1 NOSTRIN mediated eNOS trafficking DEPYRIMIDINATION%REACTOME DATABASE ID RELEASE 66%10144972 Depyrimidination PHYSIOLOGICAL FACTORS%REACTOME%R-RNO-5578768.1 Physiological factors JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1%REACTOME%R-RNO-450321.1 JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 DNA STRAND ELONGATION%REACTOME%R-RNO-69190.1 DNA strand elongation INTERFERON ALPHA BETA SIGNALING%REACTOME%R-RNO-909733.1 Interferon alpha beta signaling TOLL-LIKE RECEPTOR CASCADES%REACTOME DATABASE ID RELEASE 66%10145131 Toll-like Receptor Cascades RESOLUTION OF SISTER CHROMATID COHESION%REACTOME DATABASE ID RELEASE 66%10145894 Resolution of Sister Chromatid Cohesion GPVI-MEDIATED ACTIVATION CASCADE%REACTOME%R-RNO-114604.1 GPVI-mediated activation cascade NADE MODULATES DEATH SIGNALLING%REACTOME DATABASE ID RELEASE 66%10145330 NADE modulates death signalling RHO GTPASES ACTIVATE RHOTEKIN AND RHOPHILINS%REACTOME DATABASE ID RELEASE 66%10146121 RHO GTPases Activate Rhotekin and Rhophilins PROSTANOID LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145568 Prostanoid ligand receptors PACKAGING OF TELOMERE ENDS%REACTOME%R-RNO-171306.1 Packaging Of Telomere Ends ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING%REACTOME DATABASE ID RELEASE 66%10145740 Advanced glycosylation endproduct receptor signaling TP53 REGULATES TRANSCRIPTION OF CELL DEATH GENES%REACTOME%R-RNO-5633008.1 TP53 Regulates Transcription of Cell Death Genes FGFR2C LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 66%10145288 FGFR2c ligand binding and activation PLASMA LIPOPROTEIN ASSEMBLY%REACTOME%R-RNO-8963898.1 Plasma lipoprotein assembly ACTIVATED NTRK2 SIGNALS THROUGH FRS2 AND FRS3%REACTOME%R-RNO-9028731.1 Activated NTRK2 signals through FRS2 and FRS3 E2F MEDIATED REGULATION OF DNA REPLICATION%REACTOME DATABASE ID RELEASE 66%10145014 E2F mediated regulation of DNA replication TOLL LIKE RECEPTOR 2 (TLR2) CASCADE%REACTOME%R-RNO-181438.1 Toll Like Receptor 2 (TLR2) Cascade TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION%REACTOME%R-RNO-1474151.1 Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation RHO GTPASES ACTIVATE NADPH OXIDASES%REACTOME DATABASE ID RELEASE 66%10146047 RHO GTPases Activate NADPH Oxidases DOWNREGULATION OF ERBB2:ERBB3 SIGNALING%REACTOME%R-RNO-1358803.1 Downregulation of ERBB2:ERBB3 signaling CELL-CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 66%10145495 Cell-cell junction organization SYNTHESIS OF IPS IN THE NUCLEUS%REACTOME%R-RNO-1855191.1 Synthesis of IPs in the nucleus SYNTHESIS OF DNA%REACTOME DATABASE ID RELEASE 66%10144719 Synthesis of DNA SYNTHESIS OF BILE ACIDS AND BILE SALTS%REACTOME DATABASE ID RELEASE 66%10145312 Synthesis of bile acids and bile salts APOPTOTIC FACTOR-MEDIATED RESPONSE%REACTOME%R-RNO-111471.1 Apoptotic factor-mediated response GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT%REACTOME%R-RNO-72706.1 GTP hydrolysis and joining of the 60S ribosomal subunit INTRA-GOLGI AND RETROGRADE GOLGI-TO-ER TRAFFIC%REACTOME DATABASE ID RELEASE 66%10146192 Intra-Golgi and retrograde Golgi-to-ER traffic SIGNALING BY RECEPTOR TYROSINE KINASES%REACTOME DATABASE ID RELEASE 66%10144877 Signaling by Receptor Tyrosine Kinases TRANS-GOLGI NETWORK VESICLE BUDDING%REACTOME DATABASE ID RELEASE 66%10145468 trans-Golgi Network Vesicle Budding LIGAND-INDEPENDENT CASPASE ACTIVATION VIA DCC%REACTOME DATABASE ID RELEASE 66%10145489 Ligand-independent caspase activation via DCC IONOTROPIC ACTIVITY OF KAINATE RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145699 Ionotropic activity of kainate receptors SMAC-MEDIATED DISSOCIATION OF IAP:CASPASE COMPLEXES%REACTOME%R-RNO-111464.1 SMAC-mediated dissociation of IAP:caspase complexes MITOTIC G1-G1 S PHASES%REACTOME DATABASE ID RELEASE 66%10144725 Mitotic G1-G1 S phases HEME DEGRADATION%REACTOME%R-RNO-189483.1 Heme degradation BIOSYNTHESIS OF DPAN-3-DERIVED MARESINS%REACTOME%R-RNO-9026290.1 Biosynthesis of DPAn-3-derived maresins TP53 REGULATES TRANSCRIPTION OF ADDITIONAL CELL CYCLE GENES WHOSE EXACT ROLE IN THE P53 PATHWAY REMAIN UNCERTAIN%REACTOME%R-RNO-6804115.1 TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain FGFR3 LIGAND BINDING AND ACTIVATION%REACTOME%R-RNO-190239.1 FGFR3 ligand binding and activation MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 66%10145043 Muscle contraction DEATH RECEPTOR SIGNALLING%REACTOME DATABASE ID RELEASE 66%10144808 Death Receptor Signalling DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR)%REACTOME DATABASE ID RELEASE 66%10145798 Downstream signaling events of B Cell Receptor (BCR) TNFR1-INDUCED PROAPOPTOTIC SIGNALING%REACTOME DATABASE ID RELEASE 66%10144945 TNFR1-induced proapoptotic signaling KSRP (KHSRP) BINDS AND DESTABILIZES MRNA%REACTOME DATABASE ID RELEASE 66%10145696 KSRP (KHSRP) binds and destabilizes mRNA BIOSYNTHESIS OF PROTECTINS%REACTOME%R-RNO-9018681.1 Biosynthesis of protectins SIGNALING BY ERYTHROPOIETIN%REACTOME DATABASE ID RELEASE 66%10146295 Signaling by Erythropoietin DISINHIBITION OF SNARE FORMATION%REACTOME DATABASE ID RELEASE 66%10145035 Disinhibition of SNARE formation CATECHOLAMINE BIOSYNTHESIS%REACTOME%R-RNO-209905.1 Catecholamine biosynthesis TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES%REACTOME%R-RNO-425393.1 Transport of inorganic cations anions and amino acids oligopeptides SIGNAL ATTENUATION%REACTOME%R-RNO-74749.1 Signal attenuation NONHOMOLOGOUS END-JOINING (NHEJ)%REACTOME%R-RNO-5693571.1 Nonhomologous End-Joining (NHEJ) BASIGIN INTERACTIONS%REACTOME%R-RNO-210991.1 Basigin interactions SUMO IS CONJUGATED TO E1 (UBA2:SAE1)%REACTOME DATABASE ID RELEASE 66%10145983 SUMO is conjugated to E1 (UBA2:SAE1) NUCLEAR SIGNALING BY ERBB4%REACTOME%R-RNO-1251985.1 Nuclear signaling by ERBB4 LIPOPROTEIN METABOLISM%REACTOME DATABASE ID RELEASE 66%10145205 Lipoprotein metabolism CA ACTIVATED K+ CHANNELS%REACTOME DATABASE ID RELEASE 66%10145832 Ca activated K+ channels SYNTHESIS OF IPS IN THE ER LUMEN%REACTOME%R-RNO-1855231.1 Synthesis of IPs in the ER lumen LEUKOTRIENE RECEPTORS%REACTOME%R-RNO-391906.1 Leukotriene receptors CELL JUNCTION ORGANIZATION%REACTOME%R-RNO-446728.1 Cell junction organization PHOSPHORYLATION OF THE APC C%REACTOME DATABASE ID RELEASE 66%10145220 Phosphorylation of the APC C ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY%REACTOME DATABASE ID RELEASE 66%10145655 Zinc influx into cells by the SLC39 gene family P75 NTR RECEPTOR-MEDIATED SIGNALLING%REACTOME%R-RNO-193704.1 p75 NTR receptor-mediated signalling METABOLISM%REACTOME DATABASE ID RELEASE 66%10144767 Metabolism XBP1(S) ACTIVATES CHAPERONE GENES%REACTOME%R-RNO-381038.1 XBP1(S) activates chaperone genes COPI-MEDIATED ANTEROGRADE TRANSPORT%REACTOME%R-RNO-6807878.1 COPI-mediated anterograde transport INTERLEUKIN-12 SIGNALING%REACTOME DATABASE ID RELEASE 66%10145676 Interleukin-12 signaling NONSENSE-MEDIATED DECAY (NMD)%REACTOME%R-RNO-927802.1 Nonsense-Mediated Decay (NMD) REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE%REACTOME%R-RNO-3371453.1 Regulation of HSF1-mediated heat shock response TRANSCRIPTIONAL REGULATION BY TP53%REACTOME DATABASE ID RELEASE 66%10144748 Transcriptional Regulation by TP53 ROBO RECEPTORS BIND AKAP5%REACTOME%R-RNO-9010642.1 ROBO receptors bind AKAP5 INTERLEUKIN-35 SIGNALLING%REACTOME DATABASE ID RELEASE 66%10145680 Interleukin-35 Signalling TRANSLATION%REACTOME%R-RNO-72766.1 Translation TP53 REGULATES TRANSCRIPTION OF CASPASE ACTIVATORS AND CASPASES%REACTOME%R-RNO-6803207.1 TP53 Regulates Transcription of Caspase Activators and Caspases VISUAL PHOTOTRANSDUCTION%REACTOME%R-RNO-2187338.1 Visual phototransduction ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS%REACTOME DATABASE ID RELEASE 66%10145358 Role of phospholipids in phagocytosis TRAF6-MEDIATED INDUCTION OF TAK1 COMPLEX WITHIN TLR4 COMPLEX%REACTOME DATABASE ID RELEASE 66%10145767 TRAF6-mediated induction of TAK1 complex within TLR4 complex TRKA ACTIVATION BY NGF%REACTOME DATABASE ID RELEASE 66%10145140 TRKA activation by NGF AQUAPORIN-MEDIATED TRANSPORT%REACTOME DATABASE ID RELEASE 66%10145007 Aquaporin-mediated transport CHK1 CHK2(CDS1) MEDIATED INACTIVATION OF CYCLIN B:CDK1 COMPLEX%REACTOME%R-RNO-75035.1 Chk1 Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex NEURONAL SYSTEM%REACTOME DATABASE ID RELEASE 66%10144791 Neuronal System SIGNAL REGULATORY PROTEIN FAMILY INTERACTIONS%REACTOME DATABASE ID RELEASE 66%10145430 Signal regulatory protein family interactions RHO GTPASES ACTIVATE ROCKS%REACTOME%R-RNO-5627117.1 RHO GTPases Activate ROCKs TRIF(TICAM1)-MEDIATED TLR4 SIGNALING%REACTOME DATABASE ID RELEASE 66%10145138 TRIF(TICAM1)-mediated TLR4 signaling REGULATION OF TP53 DEGRADATION%REACTOME DATABASE ID RELEASE 66%10145361 Regulation of TP53 Degradation VITAMIN B1 (THIAMIN) METABOLISM%REACTOME%R-RNO-196819.1 Vitamin B1 (thiamin) metabolism E3 UBIQUITIN LIGASES UBIQUITINATE TARGET PROTEINS%REACTOME%R-RNO-8866654.1 E3 ubiquitin ligases ubiquitinate target proteins RESOLUTION OF D-LOOP STRUCTURES THROUGH SYNTHESIS-DEPENDENT STRAND ANNEALING (SDSA)%REACTOME DATABASE ID RELEASE 66%10146147 Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) TWIK RELATED POTASSIUM CHANNEL (TREK)%REACTOME DATABASE ID RELEASE 66%10145838 TWIK related potassium channel (TREK) REGULATION OF BETA-CELL DEVELOPMENT%REACTOME DATABASE ID RELEASE 66%10145438 Regulation of beta-cell development PROCESSIVE SYNTHESIS ON THE LAGGING STRAND%REACTOME%R-RNO-69183.1 Processive synthesis on the lagging strand CARBOXYTERMINAL POST-TRANSLATIONAL MODIFICATIONS OF TUBULIN%REACTOME%R-RNO-8955332.1 Carboxyterminal post-translational modifications of tubulin APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME DATABASE ID RELEASE 66%10145218 APC C:Cdc20 mediated degradation of mitotic proteins DEGRADATION OF AXIN%REACTOME DATABASE ID RELEASE 66%10146020 Degradation of AXIN DNA DAMAGE BYPASS%REACTOME DATABASE ID RELEASE 66%10144978 DNA Damage Bypass SIGNALING BY ACTIVIN%REACTOME%R-RNO-1502540.1 Signaling by Activin CELL DIVISION%REACTOME%R-RNO-68884.1 cell division OAS ANTIVIRAL RESPONSE%REACTOME DATABASE ID RELEASE 66%10146284 OAS antiviral response PKA-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%R-RNO-111931.1 PKA-mediated phosphorylation of CREB RHO GTPASES ACTIVATE WASPS AND WAVES%REACTOME DATABASE ID RELEASE 66%10145928 RHO GTPases Activate WASPs and WAVEs SNRNP ASSEMBLY%REACTOME%R-RNO-191859.1 snRNP Assembly CHROMOSOME MAINTENANCE%REACTOME DATABASE ID RELEASE 66%10145113 Chromosome Maintenance TRANSCRIPTIONAL REGULATION BY RUNX1%REACTOME DATABASE ID RELEASE 66%10146236 Transcriptional regulation by RUNX1 AFLATOXIN ACTIVATION AND DETOXIFICATION%REACTOME DATABASE ID RELEASE 66%10145070 Aflatoxin activation and detoxification SEROTONIN AND MELATONIN BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 66%10145426 Serotonin and melatonin biosynthesis N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI%REACTOME%R-RNO-975576.1 N-glycan antennae elongation in the medial trans-Golgi HYDROLYSIS OF LPE%REACTOME%R-RNO-1483152.1 Hydrolysis of LPE ACTIVATED NTRK3 SIGNALS THROUGH PI3K%REACTOME%R-RNO-9603381.1 Activated NTRK3 signals through PI3K SIGNAL TRANSDUCTION BY L1%REACTOME%R-RNO-445144.1 Signal transduction by L1 PDE3B SIGNALLING%REACTOME%R-RNO-165160.1 PDE3B signalling IRS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 66%10144880 IRS-mediated signalling TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE%REACTOME DATABASE ID RELEASE 66%10145154 Toll Like Receptor 7 8 (TLR7 8) Cascade ATP SENSITIVE POTASSIUM CHANNELS%REACTOME DATABASE ID RELEASE 66%10145831 ATP sensitive Potassium channels COOPERATION OF PDCL (PHLP1) AND TRIC CCT IN G-PROTEIN BETA FOLDING%REACTOME DATABASE ID RELEASE 66%10146196 Cooperation of PDCL (PhLP1) and TRiC CCT in G-protein beta folding NRIF SIGNALS CELL DEATH FROM THE NUCLEUS%REACTOME DATABASE ID RELEASE 66%10145334 NRIF signals cell death from the nucleus CD209 (DC-SIGN) SIGNALING%REACTOME%R-RNO-5621575.1 CD209 (DC-SIGN) signaling ANTIMICROBIAL PEPTIDES%REACTOME%R-RNO-6803157.1 Antimicrobial peptides VITAMIN C (ASCORBATE) METABOLISM%REACTOME DATABASE ID RELEASE 66%10145368 Vitamin C (ascorbate) metabolism DEUBIQUITINATION%REACTOME DATABASE ID RELEASE 66%10145726 Deubiquitination AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS%REACTOME DATABASE ID RELEASE 66%10145371 AKT phosphorylates targets in the nucleus INFLAMMASOMES%REACTOME DATABASE ID RELEASE 66%10145733 Inflammasomes PROCESSING OF SMDT1%REACTOME%R-RNO-8949664.1 Processing of SMDT1 COPII-MEDIATED VESICLE TRANSPORT%REACTOME%R-RNO-204005.1 COPII-mediated vesicle transport IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME DATABASE ID RELEASE 66%10145773 IRAK2 mediated activation of TAK1 complex upon TLR7 8 or 9 stimulation BIOSYNTHESIS OF DPAN-3 SPMS%REACTOME%R-RNO-9025094.1 Biosynthesis of DPAn-3 SPMs SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS%REACTOME DATABASE ID RELEASE 66%10144939 SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE%REACTOME%R-RNO-4641262.1 Disassembly of the destruction complex and recruitment of AXIN to the membrane COLLAGEN DEGRADATION%REACTOME DATABASE ID RELEASE 66%10145855 Collagen degradation PROTEIN REPAIR%REACTOME%R-RNO-5676934.1 Protein repair ACROSOME REACTION%REACTOME%R-RNO-1300645.1 Acrosome Reaction PKA ACTIVATION%REACTOME%R-RNO-163615.1 PKA activation PROCESSING OF INTRONLESS PRE-MRNAS%REACTOME DATABASE ID RELEASE 66%10144941 Processing of Intronless Pre-mRNAs NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 66%10145491 Netrin-1 signaling FMO OXIDISES NUCLEOPHILES%REACTOME%R-RNO-217271.1 FMO oxidises nucleophiles ASTROCYTIC GLUTAMATE-GLUTAMINE UPTAKE AND METABOLISM%REACTOME%R-RNO-210455.1 Astrocytic Glutamate-Glutamine Uptake And Metabolism RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES%REACTOME%R-RNO-380270.1 Recruitment of mitotic centrosome proteins and complexes METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS%REACTOME%R-RNO-196849.1 Metabolism of water-soluble vitamins and cofactors CELLULAR RESPONSE TO HYPOXIA%REACTOME%R-RNO-2262749.1 Cellular response to hypoxia PHOSPHOLIPASE C-MEDIATED CASCADE; FGFR4%REACTOME DATABASE ID RELEASE 66%10146101 Phospholipase C-mediated cascade; FGFR4 CROSSLINKING OF COLLAGEN FIBRILS%REACTOME DATABASE ID RELEASE 66%10145923 Crosslinking of collagen fibrils CELL SURFACE INTERACTIONS AT THE VASCULAR WALL%REACTOME DATABASE ID RELEASE 66%10145033 Cell surface interactions at the vascular wall FORMATION OF THE EDITOSOME%REACTOME DATABASE ID RELEASE 66%10144942 Formation of the Editosome ACTIVATION OF NOXA AND TRANSLOCATION TO MITOCHONDRIA%REACTOME DATABASE ID RELEASE 66%10145050 Activation of NOXA and translocation to mitochondria REGULATION OF THYROID HORMONE ACTIVITY%REACTOME DATABASE ID RELEASE 66%10145423 Regulation of thyroid hormone activity SODIUM-COUPLED SULPHATE, DI- AND TRI-CARBOXYLATE TRANSPORTERS%REACTOME DATABASE ID RELEASE 66%10145648 Sodium-coupled sulphate, di- and tri-carboxylate transporters APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1%REACTOME%R-RNO-174178.1 APC C:Cdh1 mediated degradation of Cdc20 and other APC C:Cdh1 targeted proteins in late mitosis early G1 BIOSYNTHESIS OF DPAN-3-DERIVED 13-SERIES RESOLVINS%REACTOME%R-RNO-9026403.1 Biosynthesis of DPAn-3-derived 13-series resolvins TP53 REGULATES TRANSCRIPTION OF DEATH RECEPTORS AND LIGANDS%REACTOME%R-RNO-6803211.1 TP53 Regulates Transcription of Death Receptors and Ligands O2 CO2 EXCHANGE IN ERYTHROCYTES%REACTOME DATABASE ID RELEASE 66%10145818 O2 CO2 exchange in erythrocytes FGFR2B LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 66%10145290 FGFR2b ligand binding and activation RAF ACTIVATION%REACTOME DATABASE ID RELEASE 66%10146124 RAF activation ARMS-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 66%10145180 ARMS-mediated activation GRB2 EVENTS IN EGFR SIGNALING%REACTOME%R-RNO-179812.1 GRB2 events in EGFR signaling HS-GAG BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 66%10145730 HS-GAG biosynthesis STAT6-MEDIATED INDUCTION OF CHEMOKINES%REACTOME%R-RNO-3249367.1 STAT6-mediated induction of chemokines DEGRADATION OF GABA%REACTOME DATABASE ID RELEASE 66%10145745 Degradation of GABA BIOSYNTHESIS OF E-SERIES 18(R)-RESOLVINS%REACTOME DATABASE ID RELEASE 66%10146300 Biosynthesis of E-series 18(R)-resolvins DNA DOUBLE STRAND BREAK RESPONSE%REACTOME%R-RNO-5693606.1 DNA Double Strand Break Response REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN%REACTOME DATABASE ID RELEASE 66%10145192 Regulation of Glucokinase by Glucokinase Regulatory Protein CYTOSOLIC SULFONATION OF SMALL MOLECULES%REACTOME%R-RNO-156584.1 Cytosolic sulfonation of small molecules CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS%REACTOME%R-RNO-264870.1 Caspase-mediated cleavage of cytoskeletal proteins DISPLACEMENT OF DNA GLYCOSYLASE BY APEX1%REACTOME%R-RNO-110357.1 Displacement of DNA glycosylase by APEX1 NICOTINAMIDE SALVAGING%REACTOME%R-RNO-197264.1 Nicotinamide salvaging TELOMERE MAINTENANCE%REACTOME DATABASE ID RELEASE 66%10145112 Telomere Maintenance RECYCLING OF EIF2:GDP%REACTOME%R-RNO-72731.1 Recycling of eIF2:GDP CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE%REACTOME DATABASE ID RELEASE 66%10144920 Cytochrome P450 - arranged by substrate type UB-SPECIFIC PROCESSING PROTEASES%REACTOME%R-RNO-5689880.1 Ub-specific processing proteases O-GLYCOSYLATION OF TSR DOMAIN-CONTAINING PROTEINS%REACTOME DATABASE ID RELEASE 66%10146044 O-glycosylation of TSR domain-containing proteins TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT%REACTOME DATABASE ID RELEASE 66%10144895 Transport of Mature mRNA derived from an Intron-Containing Transcript MET ACTIVATES PI3K AKT SIGNALING%REACTOME%R-RNO-8851907.1 MET activates PI3K AKT signaling NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME DATABASE ID RELEASE 66%10145957 NOTCH2 intracellular domain regulates transcription RET SIGNALING%REACTOME DATABASE ID RELEASE 66%10146221 RET signaling CLATHRIN-MEDIATED ENDOCYTOSIS%REACTOME DATABASE ID RELEASE 66%10146228 Clathrin-mediated endocytosis FGFR2 ALTERNATIVE SPLICING%REACTOME%R-RNO-6803529.1 FGFR2 alternative splicing NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME DATABASE ID RELEASE 66%10145624 Negative epigenetic regulation of rRNA expression C-TYPE LECTIN RECEPTORS (CLRS)%REACTOME%R-RNO-5621481.1 C-type lectin receptors (CLRs) TRANSPORT OF CONNEXINS ALONG THE SECRETORY PATHWAY%REACTOME DATABASE ID RELEASE 66%215126 Transport of connexins along the secretory pathway BICARBONATE TRANSPORTERS%REACTOME DATABASE ID RELEASE 66%10145616 Bicarbonate transporters HEMOSTASIS%REACTOME DATABASE ID RELEASE 66%10145028 Hemostasis BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS%REACTOME%R-RNO-111453.1 BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members POSITIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%R-RNO-5250913.1 Positive epigenetic regulation of rRNA expression DEGRADATION OF CYSTEINE AND HOMOCYSTEINE%REACTOME DATABASE ID RELEASE 66%10145890 Degradation of cysteine and homocysteine TRANSPORT OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 66%10144953 Transport of small molecules INTERLEUKIN-1 PROCESSING%REACTOME%R-RNO-448706.1 Interleukin-1 processing FC EPSILON RECEPTOR (FCERI) SIGNALING%REACTOME DATABASE ID RELEASE 66%10145167 Fc epsilon receptor (FCERI) signaling SEROTONIN RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145563 Serotonin receptors REVERSAL OF ALKYLATION DAMAGE BY DNA DIOXYGENASES%REACTOME DATABASE ID RELEASE 66%10146230 Reversal of alkylation damage by DNA dioxygenases PROTEIN-PROTEIN INTERACTIONS AT SYNAPSES%REACTOME%R-RNO-6794362.1 Protein-protein interactions at synapses MET PROMOTES CELL MOTILITY%REACTOME DATABASE ID RELEASE 66%10146247 MET promotes cell motility MRNA EDITING: C TO U CONVERSION%REACTOME%R-RNO-72200.1 mRNA Editing: C to U Conversion ECM PROTEOGLYCANS%REACTOME%R-RNO-3000178.1 ECM proteoglycans P38MAPK EVENTS%REACTOME DATABASE ID RELEASE 66%10145201 p38MAPK events INNATE IMMUNE SYSTEM%REACTOME%R-RNO-168249.1 Innate Immune System TRANSMISSION ACROSS ELECTRICAL SYNAPSES%REACTOME DATABASE ID RELEASE 66%10145508 Transmission across Electrical Synapses EPHA-MEDIATED GROWTH CONE COLLAPSE%REACTOME DATABASE ID RELEASE 66%10146028 EPHA-mediated growth cone collapse IRF3 MEDIATED ACTIVATION OF TYPE 1 IFN%REACTOME%R-RNO-1606341.1 IRF3 mediated activation of type 1 IFN HDL REMODELING%REACTOME DATABASE ID RELEASE 66%10145453 HDL remodeling SIGNALING BY GPCR%REACTOME DATABASE ID RELEASE 66%10144870 Signaling by GPCR ELASTIC FIBRE FORMATION%REACTOME%R-RNO-1566948.1 Elastic fibre formation FGFR4 LIGAND BINDING AND ACTIVATION%REACTOME%R-RNO-190322.1 FGFR4 ligand binding and activation INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION%REACTOME%R-RNO-400508.1 Incretin synthesis, secretion, and inactivation METALLOTHIONEINS BIND METALS%REACTOME%R-RNO-5661231.1 Metallothioneins bind metals INSULIN PROCESSING%REACTOME DATABASE ID RELEASE 66%10145456 Insulin processing ANCHORING FIBRIL FORMATION%REACTOME%R-RNO-2214320.1 Anchoring fibril formation MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF UNSATURATED FATTY ACIDS%REACTOME DATABASE ID RELEASE 66%10144949 mitochondrial fatty acid beta-oxidation of unsaturated fatty acids SCAVENGING BY CLASS A RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145956 Scavenging by Class A Receptors CLATHRIN DERIVED VESICLE BUDDING%REACTOME%R-RNO-421837.1 Clathrin derived vesicle budding SCAVENGING BY CLASS H RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145959 Scavenging by Class H Receptors POLB-DEPENDENT LONG PATCH BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 66%10146093 POLB-Dependent Long Patch Base Excision Repair MACROAUTOPHAGY%REACTOME%R-RNO-1632852.1 Macroautophagy GOLGI ASSOCIATED VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 66%10145614 Golgi Associated Vesicle Biogenesis HEDGEHOG LIGAND BIOGENESIS%REACTOME%R-RNO-5358346.1 Hedgehog ligand biogenesis SIGNALING BY NTRK3 (TRKC)%REACTOME DATABASE ID RELEASE 66%10146326 Signaling by NTRK3 (TRKC) SIGNALING BY NTRK2 (TRKB)%REACTOME DATABASE ID RELEASE 66%10146316 Signaling by NTRK2 (TRKB) NEGATIVE REGULATION OF NOTCH4 SIGNALING%REACTOME DATABASE ID RELEASE 66%10146331 Negative regulation of NOTCH4 signaling ERBB2 ACTIVATES PTK6 SIGNALING%REACTOME%R-RNO-8847993.1 ERBB2 Activates PTK6 Signaling WNT MEDIATED ACTIVATION OF DVL%REACTOME DATABASE ID RELEASE 66%10145393 WNT mediated activation of DVL DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY%REACTOME%R-RNO-2173795.1 Downregulation of SMAD2 3:SMAD4 transcriptional activity REGULATION OF IGF ACTIVITY BY IGFBP%REACTOME%R-RNO-381426.1 Regulation of IGF Activity by IGFBP EUKARYOTIC TRANSLATION TERMINATION%REACTOME DATABASE ID RELEASE 66%10146146 Eukaryotic Translation Termination ACTIVATED NTRK3 SIGNALS THROUGH PLCG1%REACTOME DATABASE ID RELEASE 66%10146327 Activated NTRK3 signals through PLCG1 THE NLRP1 INFLAMMASOME%REACTOME DATABASE ID RELEASE 66%10145732 The NLRP1 inflammasome SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP)%REACTOME%R-RNO-400511.1 Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER%REACTOME%R-RNO-76061.1 RNA Polymerase III Transcription Initiation From Type 1 Promoter TRANSCRIPTIONAL REGULATION BY MECP2%REACTOME%R-RNO-8986944.1 Transcriptional Regulation by MECP2 MITOCHONDRIAL TRANSLATION%REACTOME%R-RNO-5368287.1 Mitochondrial translation PROTEIN LOCALIZATION%REACTOME DATABASE ID RELEASE 66%10146283 Protein localization CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX%REACTOME%R-RNO-68689.1 CDC6 association with the ORC:origin complex RESOLUTION OF D-LOOP STRUCTURES%REACTOME%R-RNO-5693537.1 Resolution of D-Loop Structures SPHINGOLIPID DE NOVO BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 66%10145630 Sphingolipid de novo biosynthesis CLEARANCE OF DOPAMINE%REACTOME%R-RNO-379401.1 Clearance of dopamine GABA SYNTHESIS%REACTOME DATABASE ID RELEASE 66%10145746 GABA synthesis SUMOYLATION OF TRANSCRIPTION COFACTORS%REACTOME DATABASE ID RELEASE 66%10145995 SUMOylation of transcription cofactors SIGNALING BY WNT%REACTOME DATABASE ID RELEASE 66%10145342 Signaling by WNT ESTROGEN BIOSYNTHESIS%REACTOME%R-RNO-193144.1 Estrogen biosynthesis SUMOYLATION OF CHROMATIN ORGANIZATION PROTEINS%REACTOME%R-RNO-4551638.1 SUMOylation of chromatin organization proteins CLEAVAGE OF THE DAMAGED PURINE%REACTOME DATABASE ID RELEASE 66%10144974 Cleavage of the damaged purine DEPOLYMERISATION OF THE NUCLEAR LAMINA%REACTOME DATABASE ID RELEASE 66%10146031 Depolymerisation of the Nuclear Lamina EPIGENETIC REGULATION OF GENE EXPRESSION%REACTOME DATABASE ID RELEASE 66%10145445 Epigenetic regulation of gene expression REACTIONS SPECIFIC TO THE HYBRID N-GLYCAN SYNTHESIS PATHWAY%REACTOME%R-RNO-975574.1 Reactions specific to the hybrid N-glycan synthesis pathway RHO GTPASES ACTIVATE PAKS%REACTOME%R-RNO-5627123.1 RHO GTPases activate PAKs DEGRADATION OF DVL%REACTOME DATABASE ID RELEASE 66%10145877 Degradation of DVL TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS%REACTOME DATABASE ID RELEASE 66%10145193 TGF-beta receptor signaling activates SMADs PYRUVATE METABOLISM%REACTOME%R-RNO-70268.1 Pyruvate metabolism PLATELET ACTIVATION, SIGNALING AND AGGREGATION%REACTOME DATABASE ID RELEASE 66%10145027 Platelet activation, signaling and aggregation LOSS OF NLP FROM MITOTIC CENTROSOMES%REACTOME%R-RNO-380259.1 Loss of Nlp from mitotic centrosomes CAM PATHWAY%REACTOME DATABASE ID RELEASE 66%10144992 CaM pathway SIGNALING BY SCF-KIT%REACTOME DATABASE ID RELEASE 66%10145420 Signaling by SCF-KIT TIGHT JUNCTION INTERACTIONS%REACTOME%R-RNO-420029.1 Tight junction interactions NUCLEOTIDE METABOLISM%REACTOME DATABASE ID RELEASE 66%10144816 Nucleotide metabolism INHIBITION OF ADENYLATE CYCLASE PATHWAY%REACTOME%R-RNO-997269.1 Inhibition of adenylate cyclase pathway RNA POLYMERASE II TRANSCRIBES SNRNA GENES%REACTOME DATABASE ID RELEASE 66%10146187 RNA polymerase II transcribes snRNA genes MRNA DECAY BY 3' TO 5' EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 66%10145639 mRNA decay by 3' to 5' exoribonuclease AMINE-DERIVED HORMONES%REACTOME%R-RNO-209776.1 Amine-derived hormones PROGRESSIVE TRIMMING OF ALPHA-1,2-LINKED MANNOSE RESIDUES FROM MAN9 8 7GLCNAC2 TO PRODUCE MAN5GLCNAC2%REACTOME%R-RNO-964827.1 Progressive trimming of alpha-1,2-linked mannose residues from Man9 8 7GlcNAc2 to produce Man5GlcNAc2 AMINO ACID AND DERIVATIVE METABOLISM%REACTOME%R-RNO-71291.1 Amino acid and derivative metabolism INOSITOL PHOSPHATE METABOLISM%REACTOME%R-RNO-1483249.1 Inositol phosphate metabolism FORMATION OF ATP BY CHEMIOSMOTIC COUPLING%REACTOME DATABASE ID RELEASE 66%10145126 Formation of ATP by chemiosmotic coupling ACTIVATION OF SMO%REACTOME DATABASE ID RELEASE 66%10146091 Activation of SMO GLI3 IS PROCESSED TO GLI3R BY THE PROTEASOME%REACTOME DATABASE ID RELEASE 66%10146075 GLI3 is processed to GLI3R by the proteasome RELEASE OF HH-NP FROM THE SECRETING CELL%REACTOME DATABASE ID RELEASE 66%10146062 Release of Hh-Np from the secreting cell ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES%REACTOME%R-RNO-2022090.1 Assembly of collagen fibrils and other multimeric structures PEROXISOMAL PROTEIN IMPORT%REACTOME DATABASE ID RELEASE 66%10146282 Peroxisomal protein import RECYCLING PATHWAY OF L1%REACTOME DATABASE ID RELEASE 66%10145501 Recycling pathway of L1 VASOPRESSIN REGULATES RENAL WATER HOMEOSTASIS VIA AQUAPORINS%REACTOME%R-RNO-432040.1 Vasopressin regulates renal water homeostasis via Aquaporins PI5P REGULATES TP53 ACETYLATION%REACTOME%R-RNO-6811555.1 PI5P Regulates TP53 Acetylation HYPUSINYLATION%REACTOME%R-RNO-204626.1 Hypusinylation UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1%REACTOME DATABASE ID RELEASE 66%10144899 Ubiquitin-dependent degradation of Cyclin D1 VEGFA-VEGFR2 PATHWAY%REACTOME DATABASE ID RELEASE 66%10145272 VEGFA-VEGFR2 Pathway TRANSCRIPTIONAL REGULATION BY RUNX3%REACTOME%R-RNO-8878159.1 Transcriptional regulation by RUNX3 TP53 REGULATES TRANSCRIPTION OF DNA REPAIR GENES%REACTOME DATABASE ID RELEASE 66%10146165 TP53 Regulates Transcription of DNA Repair Genes PI-3K CASCADE:FGFR2%REACTOME DATABASE ID RELEASE 66%10145254 PI-3K cascade:FGFR2 TRANSLESION SYNTHESIS BY REV1%REACTOME DATABASE ID RELEASE 66%10144976 Translesion synthesis by REV1 SHC1 EVENTS IN ERBB4 SIGNALING%REACTOME DATABASE ID RELEASE 66%10145825 SHC1 events in ERBB4 signaling TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM%REACTOME DATABASE ID RELEASE 66%10144896 Transport of Mature Transcript to Cytoplasm CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 66%10144717 CDT1 association with the CDC6:ORC:origin complex ACTIVATION OF BMF AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%R-RNO-139910.1 Activation of BMF and translocation to mitochondria CELL CYCLE, MITOTIC%REACTOME DATABASE ID RELEASE 66%10144721 Cell Cycle, Mitotic NEGATIVE REGULATION OF MET ACTIVITY%REACTOME%R-RNO-6807004.1 Negative regulation of MET activity MTOR SIGNALLING%REACTOME DATABASE ID RELEASE 66%10145128 mTOR signalling PURINE CATABOLISM%REACTOME%R-RNO-74259.1 Purine catabolism PHENYLALANINE AND TYROSINE CATABOLISM%REACTOME%R-RNO-71182.1 Phenylalanine and tyrosine catabolism SYNTHESIS OF DIPHTHAMIDE-EEF2%REACTOME DATABASE ID RELEASE 66%10146058 Synthesis of diphthamide-EEF2 TRIGLYCERIDE CATABOLISM%REACTOME%R-RNO-163560.1 Triglyceride catabolism CD28 CO-STIMULATION%REACTOME DATABASE ID RELEASE 66%10145354 CD28 co-stimulation REMOVAL OF AMINOTERMINAL PROPEPTIDES FROM GAMMA-CARBOXYLATED PROTEINS%REACTOME%R-RNO-159782.1 Removal of aminoterminal propeptides from gamma-carboxylated proteins EGFR TRANSACTIVATION BY GASTRIN%REACTOME%R-RNO-2179392.1 EGFR Transactivation by Gastrin GENE SILENCING BY RNA%REACTOME DATABASE ID RELEASE 66%10145435 Gene Silencing by RNA RUNX1 REGULATES GENES INVOLVED IN MEGAKARYOCYTE DIFFERENTIATION AND PLATELET FUNCTION%REACTOME%R-RNO-8936459.1 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function ONCOGENE INDUCED SENESCENCE%REACTOME DATABASE ID RELEASE 66%10145265 Oncogene Induced Senescence BIOSYNTHESIS OF MARESIN CONJUGATES IN TISSUE REGENERATION (MCTR)%REACTOME DATABASE ID RELEASE 66%10146313 Biosynthesis of maresin conjugates in tissue regeneration (MCTR) ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS%REACTOME DATABASE ID RELEASE 66%10145721 Acetylcholine binding and downstream events LIPID PARTICLE ORGANIZATION%REACTOME%R-RNO-8964572.1 Lipid particle organization TYPE I HEMIDESMOSOME ASSEMBLY%REACTOME DATABASE ID RELEASE 66%10145647 Type I hemidesmosome assembly METABOLISM OF INGESTED MESEO2H INTO MESEH%REACTOME%R-RNO-5263617.1 Metabolism of ingested MeSeO2H into MeSeH PROTEIN METHYLATION%REACTOME%R-RNO-8876725.1 Protein methylation SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE%REACTOME DATABASE ID RELEASE 66%10145901 Synthesis of PIPs at the Golgi membrane LAMININ INTERACTIONS%REACTOME DATABASE ID RELEASE 66%10145448 Laminin interactions SMAC BINDS TO IAPS%REACTOME%R-RNO-111463.1 SMAC binds to IAPs NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING%REACTOME%R-RNO-936440.1 Negative regulators of RIG-I MDA5 signaling HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM%REACTOME DATABASE ID RELEASE 66%10145731 Heparan sulfate heparin (HS-GAG) metabolism APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS%REACTOME DATABASE ID RELEASE 66%10145386 Apoptotic cleavage of cell adhesion proteins ASPARAGINE N-LINKED GLYCOSYLATION%REACTOME%R-RNO-446203.1 Asparagine N-linked glycosylation FORMATION OF FIBRIN CLOT (CLOTTING CASCADE)%REACTOME%R-RNO-140877.1 Formation of Fibrin Clot (Clotting Cascade) CD28 DEPENDENT PI3K AKT SIGNALING%REACTOME%R-RNO-389357.1 CD28 dependent PI3K Akt signaling TYSND1 CLEAVES PEROXISOMAL PROTEINS%REACTOME DATABASE ID RELEASE 66%10146324 TYSND1 cleaves peroxisomal proteins INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX%REACTOME%R-RNO-141430.1 Inactivation of APC C via direct inhibition of the APC C complex GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION%REACTOME%R-RNO-162658.1 Golgi Cisternae Pericentriolar Stack Reorganization LYSOSOME VESICLE BIOGENESIS%REACTOME%R-RNO-432720.1 Lysosome Vesicle Biogenesis PD-1 SIGNALING%REACTOME%R-RNO-389948.1 PD-1 signaling TRANSPORT OF BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS%REACTOME%R-RNO-425366.1 Transport of bile salts and organic acids, metal ions and amine compounds SIGNALLING TO RAS%REACTOME DATABASE ID RELEASE 66%10145202 Signalling to RAS ACTIVATION OF NF-KAPPAB IN B CELLS%REACTOME%R-RNO-1169091.1 Activation of NF-kappaB in B cells NUCLEOSOME ASSEMBLY%REACTOME%R-RNO-774815.1 Nucleosome assembly DDX58 IFIH1-MEDIATED INDUCTION OF INTERFERON-ALPHA BETA%REACTOME%R-RNO-168928.1 DDX58 IFIH1-mediated induction of interferon-alpha beta EGFR DOWNREGULATION%REACTOME DATABASE ID RELEASE 66%10145266 EGFR downregulation INTERLEUKIN-1 FAMILY SIGNALING%REACTOME DATABASE ID RELEASE 66%10145170 Interleukin-1 family signaling SUMOYLATION OF INTRACELLULAR RECEPTORS%REACTOME%R-RNO-4090294.1 SUMOylation of intracellular receptors RUNX3 REGULATES P14-ARF%REACTOME DATABASE ID RELEASE 66%10146279 RUNX3 regulates p14-ARF ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS%REACTOME DATABASE ID RELEASE 66%10145174 ZBP1(DAI) mediated induction of type I IFNs PROTON OLIGOPEPTIDE COTRANSPORTERS%REACTOME DATABASE ID RELEASE 66%10145629 Proton oligopeptide cotransporters METALLOPROTEASE DUBS%REACTOME DATABASE ID RELEASE 66%10146145 Metalloprotease DUBs ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION%REACTOME%R-RNO-450302.1 activated TAK1 mediates p38 MAPK activation NEGATIVE FEEDBACK REGULATION OF MAPK PATHWAY%REACTOME%R-RNO-5674499.1 Negative feedback regulation of MAPK pathway ALPHA-OXIDATION OF PHYTANATE%REACTOME DATABASE ID RELEASE 66%10145549 Alpha-oxidation of phytanate LIGAND-DEPENDENT CASPASE ACTIVATION%REACTOME DATABASE ID RELEASE 66%10144860 Ligand-dependent caspase activation PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE%REACTOME DATABASE ID RELEASE 66%10144782 Pyruvate metabolism and Citric Acid (TCA) cycle CD28 DEPENDENT VAV1 PATHWAY%REACTOME DATABASE ID RELEASE 66%10145542 CD28 dependent Vav1 pathway AMINE LIGAND-BINDING RECEPTORS%REACTOME%R-RNO-375280.1 Amine ligand-binding receptors MRNA DECAY BY 5' TO 3' EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 66%10145636 mRNA decay by 5' to 3' exoribonuclease MOLYBDENUM COFACTOR BIOSYNTHESIS%REACTOME%R-RNO-947581.1 Molybdenum cofactor biosynthesis TRANSLESION SYNTHESIS BY Y FAMILY DNA POLYMERASES BYPASSES LESIONS ON DNA TEMPLATE%REACTOME DATABASE ID RELEASE 66%10144977 Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template HISTIDINE, LYSINE, PHENYLALANINE, TYROSINE, PROLINE AND TRYPTOPHAN CATABOLISM%REACTOME DATABASE ID RELEASE 66%10144795 Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism SPERM MOTILITY AND TAXES%REACTOME%R-RNO-1300642.1 Sperm Motility And Taxes ENZYMATIC DEGRADATION OF DOPAMINE BY COMT%REACTOME DATABASE ID RELEASE 66%10145520 Enzymatic degradation of dopamine by COMT REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE%REACTOME%R-RNO-176408.1 Regulation of APC C activators between G1 S and early anaphase RNA POLYMERASE III TRANSCRIPTION%REACTOME%R-RNO-74158.1 RNA Polymerase III Transcription ACTIVATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME DATABASE ID RELEASE 66%10144871 Activation of the phototransduction cascade FERTILIZATION%REACTOME%R-RNO-1187000.1 Fertilization SIGNAL AMPLIFICATION%REACTOME%R-RNO-392518.1 Signal amplification ACTIVATED PKN1 STIMULATES TRANSCRIPTION OF AR (ANDROGEN RECEPTOR) REGULATED GENES KLK2 AND KLK3%REACTOME DATABASE ID RELEASE 66%10146086 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE%REACTOME%R-RNO-174414.1 Processive synthesis on the C-strand of the telomere IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 66%10145133 Immune System PORPHYRIN METABOLISM%REACTOME DATABASE ID RELEASE 66%10145085 Porphyrin metabolism RA BIOSYNTHESIS PATHWAY%REACTOME%R-RNO-5365859.1 RA biosynthesis pathway CLASSICAL KIR CHANNELS%REACTOME DATABASE ID RELEASE 66%10145835 Classical Kir channels REGULATION BY C-FLIP%REACTOME DATABASE ID RELEASE 66%10146009 Regulation by c-FLIP PROTEIN UBIQUITINATION%REACTOME DATABASE ID RELEASE 66%10146215 Protein ubiquitination THROMBOXANE SIGNALLING THROUGH TP RECEPTOR%REACTOME%R-RNO-428930.1 Thromboxane signalling through TP receptor APC C:CDC20 MEDIATED DEGRADATION OF SECURIN%REACTOME%R-RNO-174154.1 APC C:Cdc20 mediated degradation of Securin SHC1 EVENTS IN EGFR SIGNALING%REACTOME%R-RNO-180336.1 SHC1 events in EGFR signaling CHYLOMICRON REMODELING%REACTOME DATABASE ID RELEASE 66%10145241 Chylomicron remodeling PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA%REACTOME%R-RNO-72203.1 Processing of Capped Intron-Containing Pre-mRNA INSULIN RECEPTOR RECYCLING%REACTOME%R-RNO-77387.1 Insulin receptor recycling INTERLEUKIN-6 SIGNALING%REACTOME DATABASE ID RELEASE 66%10145796 Interleukin-6 signaling ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%R-RNO-111447.1 Activation of BAD and translocation to mitochondria Ywhah Ywhag Sfn Ywhaz Ppp3r1 Bcl2 Bid Ywhab Ywhaq Ywhae Bad C-SRC MEDIATED REGULATION OF CX43 FUNCTION AND CLOSURE OF GAP JUNCTIONS%REACTOME%R-RNO-191647.1 c-src mediated regulation of Cx43 function and closure of gap junctions Gja1 Src EUKARYOTIC TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 66%10144835 Eukaryotic Translation Initiation LOC100912571 Eif3l Eif2s3 Eif3m Eif3j Eif4ebp1 Eif3k Rps20 Rps27l Eif3e Eif3f Eif2b1 Eif3b Eif3a Eif3d Eif3c LOC100360573 Eif2s1 Eif2s2 Eif4g1 Rps4x LOC100359951 LOC100359593 Eif5 LOC100359503 LOC100362640 Rpl13a Rps3 Rps15a Rps2 Rps13 Rps12 Pabpc2 Pabpc6 LOC100911372 LOC100361854 LOC684988 LOC103689992 Rps5 Rps7 Eif2b5 Rps6 Eif2b3 Eif2b4 Eif3g Eif3h Eif4a2 LOC100362830 Eif1ax Eif4a1 LOC100363012 LOC680559 LOC100911110 LOC100362149 Rps16 LOC100911431 Pabpc1 Rps18 LOC100360679 Rps15 Eif4h Eif4b Rps3a TIE2 SIGNALING%REACTOME%R-RNO-210993.1 Tie2 Signaling Kras Grb7 Dok2 Pik3r1 Pik3r2 Pik3cb Tek Ptpn11 Angpt1 Hras Nras Sos1 Angpt2 Angpt4 Shc1 Grb2 SMALL INTERFERING RNA (SIRNA) BIOGENESIS%REACTOME%R-RNO-426486.1 Small interfering RNA (siRNA) biogenesis Prkra Ago3 Dicer1 Tsnax Ago4 Ago2 Tsn Tarbp2 ARACHIDONATE PRODUCTION FROM DAG%REACTOME%R-RNO-426048.1 Arachidonate production from DAG Mgll Abhd12 Daglb Abhd6 Dagla NUCLEOTIDE EXCISION REPAIR%REACTOME%R-RNO-5696398.1 Nucleotide Excision Repair Rfc1 Rfc2 Gtf2h1 Gtf2h2 Usp7 Ddb2 Pole2 Pole4 Pias3 Pias1 Ppie Yy1 Ddb1 Mnat1 Rbx1 RGD1565904 Actr8 Isy1 Polr2g Polr2h Polr2e Polr2f Polr2j Polr2k Polr2d Polr2i Polr2b Polr2c Chd1l Polr2a Actl6a Mcrs1 Xab2 Cops8 LOC100912534 Cops2 Actb Sumo1 Rpa3 Lig3 Zfp830 Pole Prpf19 Sumo3 Ino80 Tcea1 Pcna Cul4b Uvssa Ccnh Cul4a Ube2v2 Hmgn1 Xpc Ube2n Xpa Ube2i Ruvbl1 Gtf2h3 Rfc5 Rfc4 Rfc3 Gtf2h5 Gtf2h4 Ercc5 Ercc8 Ercc3 Ercc6 Rpa1 Rpa2 LOC100911295 LOC100911822 Cops4 Aqr Cops6 Ercc2 Ercc1 Lig1 Cops3 Ino80e Ino80d Nfrkb Usp45 Xrcc1 Parp2 Parp1 Rad23a LOC100911727 Cdk7 Rad23b Cops7b Cops7a Pold2 Pold1 Pold4 Ino80b Ino80c CAP-DEPENDENT TRANSLATION INITIATION%REACTOME%R-RNO-72737.1 Cap-dependent Translation Initiation LOC100912571 Eif3l Eif2s3 Eif3m Eif3j Eif4ebp1 Eif3k Rps20 Rps27l Eif3e Eif3f Eif2b1 Eif3b Eif3a Eif3d Eif3c LOC100360573 Eif2s1 Eif2s2 Eif4g1 Rps4x LOC100359951 LOC100359593 Eif5 LOC100359503 LOC100362640 Rps3 Rps15a Rps2 Rps13 Rps12 Pabpc2 Pabpc6 LOC100911372 LOC100361854 LOC684988 LOC103689992 Rps5 Rps7 Eif2b5 Rps6 Eif2b3 Eif2b4 Eif3g Eif3h Eif4a2 LOC100362830 Eif1ax Eif4a1 LOC100363012 LOC680559 LOC100911110 LOC100362149 Rps16 LOC100911431 Pabpc1 Rps18 LOC100360679 Rps15 Eif4h Eif4b Rps3a TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE%REACTOME%R-RNO-168188.1 Toll Like Receptor TLR6:TLR2 Cascade Map2k7 Ripk2 Map2k6 Ager Dusp3 Map2k4 Map3k8 Dusp4 Peli3 Nfkbib LOC100912399 Peli2 Map3k1 Traf6 Cul1 Vrk3 Rps6ka2 Rps6ka1 App Rps6ka3 Rps6ka5 Tirap LOC100912585 Tab1 Dusp7 Dusp6 Rela Atf1 Atf2 Map3k7 Peli1 Irak2 Nfkbia LOC100910771 Ube2n Jun Ppp2cb Ppp2ca Skp1 Ppp2r1a Nfkb2 Nfkb1 Mapk9 Mapk8 Fos S100b Mapk7 Dhx9 Fbxw11 Chuk Ppp2r1b Ecsit Mapkapk3 Btrc Mapkapk2 Mapk1 Nkiras1 LOC100362142 Nod1 Nod2 Nkiras2 Creb1 Tab2 Tab3 LOC100912618 Ube2v1 Ikbkb Mapk14 Myd88 Tnip2 Mapk11 Mapk10 CARBOHYDRATE METABOLISM%REACTOME DATABASE ID RELEASE 66%10144766 Carbohydrate metabolism Xylb Ncan Hexb Hexa Chst7 Chst9 Ugp2 Slc9a1 Chst5 LOC102550316 Chst3 Nup88 Chst2 Chst1 B3gnt4 B3gnt7 B3gnt1 B3gnt2 B3gnt3 Nup85 Pgk2 G6pc3 Pgk1 Gpc6 Rbks Slc37a2 Pkm Taldo1 Chpf2 Gpc4 Gpc2 Ndst1 Pgam1 Pgam2 Ndst2 Rae1 Cryl1 Ndst3 Ndst4 Adpgk Ogn Glb1 Pck1 St3gal2 St3gal3 Slc26a2 Slc26a1 St3gal1 Bpgm Gpc1 Nhlrc1 Slc37a1 St3gal4 St3gal6 B3galt6 Nup93 Slc35b2 Epm2a Kera Nup98 LOC100911625 Nup107 Slc35b3 Eno3 Glyctk Gapdhs Manba Eno1 Tkfc Eno2 Nup210 Aldoa Prelp LOC100911750 Gyg1 Aldob Aldoc Cspg5 Cspg4 Nupl2 Pgls Gckr Nupl1 Pklr Acan Pc Dsel Tkt Bcan Pfkfb3 Pfkfb4 Pfkfb1 Pfkfb2 Chsy1 Khk Pfkl Pgm2 Prps2 Pgm1 LOC100910284 Pfkp B4galt1 Ext1 Ext2 B4galt3 B4galt2 B4galt6 B4galt7 B4galt4 B4galt5 Hs3st3b1 Nup205 Aldoart2 Naglu Slc25a11 Lalba Slc25a10 Phka1 Cemip Shpk Agrn Stab2 Hk2 Xylt2 Pgm2l1 G6pc Agl Chst12 Nup155 Chst11 Lum Dcn Tpi1 Csgalnact1 Csgalnact2 Hs6st2 Chst13 Prps1l1 Gys1 Gpi Gys2 Slc25a1 Rpia Papss2 Papss1 Hs6st1 Idua Ust Chst15 Chst14 Nup153 Rpe Vcan Phkg1 Gale Hs3st3a1 Omd Dse Tpr Glb1l Galk1 Akr1b1 Arsb LOC100910891 Phkg2 Man2c1 Gnpda2 Dera Akr1a1 Slc35d2 Nup54 Gusb Hpse Man2b1 Slc2a1 Pom121 Hs3st5 Chpf Nup62 Hs3st2 Hs3st1 Dcxr Hs3st6 Cd44 Phkb Lyve1 Nup43 Nup133 Mdh2 Gaa Mdh1 Has1 Aaas Pygl Has2 Pygm B3gat1 B3gat3 B3gat2 Npap60 Got1 Fbp1 Nup35 Fbp2 Hyal1 Nup37 Hyal2 Chp1 Sdc2 Sdc3 Sdc4 Sord Fmod Galt Got2 Hs2st1 Ranbp2 Ppp1r3c ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS%REACTOME%R-RNO-176187.1 Activation of ATR in response to replication stress Rfc2 Hus1 Rpa1 Rpa2 Mcm2 Atrip Mcm4 Mcm3 Cdk2 Mcm5 Clspn Rpa3 Mcm6 Mcm10 Rad1 Atr Mcm8 Mcm7 Rad17 Orc4 Orc5 Orc6 Orc1 Orc2 Orc3 Rfc5 Cdc7 Rfc4 Rad9a Rfc3 Cdc6 Rad9b Cdc45 EXTRACELLULAR MATRIX ORGANIZATION%REACTOME DATABASE ID RELEASE 66%10145031 Extracellular matrix organization Capn5 RGD1308751 Capn7 Itga4 Capn9 LOC102553715 Serpine1 Capn8 Itga6 Itga8 Itga7 Elane Col20a1 Ncan P4ha1 P4ha2 P4ha3 Adam8 Bsg LOC100910835 Col13a1 LOC100910384 Vcam1 F11r Sh3pxd2a LOC103690254 Serpinh1 Try10 LOC100365995 Ddr1 Col8a1 LOC102550316 Col8a2 Pdgfa Pdgfb Timp2 Timp1 Phykpl Col28a1 Col1a1 Cma1 Efemp1 Col1a2 Cdh1 Efemp2 Fbln2 Col18a1 MGC114246 A2m Fbln1 Kdr Fbln5 Dmp1 Capn15 Capn1 Itga3 Capn6 Scube3 Scube1 Capn3 Capn2 Capn10 Testin Lama4 Loxl4 Colgalt2 Plg Prkca Col14a1 Capn12 Loxl1 Capn11 Colgalt1 Lama1 Ceacam10 Col17a1 Capn13 Mmp8 Ibsp Itgam Mmp7 Col19a1 Itgae LOC100911730 Mmp9 Try4 Itgb6 Sparc Pcolce Mmp1 Mmp2 Itgb7 Itgb8 Madcam1 Itgb2 Cd151 Tnn Lamc1 Lamc2 Vtn Itgb4 Adam12 Adam19 Jam3 Col22a1 Fbn1 Acan Col16a1 Tnr Adam15 Ceacam1 Col5a2 Bcan Col5a1 Klk7 Col4a5 Col9a1 Col9a2 Col9a3 Mfap2 Col4a1 Fgb Prss2 Fgg LOC100910284 Mfap5 Mfap4 Col5a3 LOC100364523 Thbs1 Ctrb1 Optc Col4a2 Col4a3 Fga Mfap3 Lamb1 Itgal Dag1 Itgax Lamb2 Lamb3 Prss1 Spp1 Icam4 Agrn Mmp15 Mmp17 Icam5 Mmp11 Mmp12 Mmp14 Dst Icam1 Mmp13 Mmp19 Lum Adamts4 Adamts3 Dcn Adamts5 Klkb1 Comp Ctsd Ctsb Ctsg Ctsl Col3a1 Ctsm Itga10 Ctsj RGD1564657 Itga11 Ctsk Ctsq Ctsr Ppib Col6a1 Col6a2 Fn1 LOC100909977 Vcan P4hb LOC102554637 Adamts14 Tll2 Col11a2 Col11a1 Mmp20 Gdf5 Tmprss6 Tll1 Ltbp3 Ltbp2 Ltbp4 Ltbp1 Tpsab1 Mmp24 LOC100911572 P3h3 Cts8 Cts7 Col26a1 Itga2b Plod2 Plod1 RGD1564827 LOC102555086 Mmp16 Icam2 Plod3 Mmp10 Cd44 Sdc2 Sdc3 Sdc4 LOC683849 Furin LOC100911714 Tpsb2 Cd47 Cts8l1 Spock3 Col27a1 Htra1 Dspp Lox Plec Fgf2 Ttr Nid1 Nid2 Hapln1 Eln Bmp2 LOC100910122 Bmp1 Matn4 Bmp7 Bmp4 Crtap Matn1 Col7a1 Tgfb2 Tgfb1 Col23a1 Cast Tgfb3 Col6a5 Col6a6 LEADING STRAND SYNTHESIS%REACTOME%R-RNO-69109.1 Leading Strand Synthesis Rfc1 Rfc2 Prim2 Pola2 Prim1 Rfc5 Rfc4 Pold2 Rfc3 Pcna Pold1 Pold4 REGULATED PROTEOLYSIS OF P75NTR%REACTOME DATABASE ID RELEASE 66%10145335 Regulated proteolysis of p75NTR Nfkb1 Adam17 Aph1b Psenen Aph1a Ngfr Rela LOC100911293 Psen2 Psen1 Traf6 Ncstn MISMATCH REPAIR (MMR) DIRECTED BY MSH2:MSH3 (MUTSBETA)%REACTOME%R-RNO-5358606.1 Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Msh3 Msh2 Rpa1 Rpa3 Rpa2 LOC100911727 Pold2 Pold1 Lig1 Pold4 NEUTROPHIL DEGRANULATION%REACTOME%R-RNO-6798695.1 Neutrophil degranulation Ppie Elane Adam8 LOC103690254 Try10 LOC100365995 Timp2 Capn1 Ceacam10 Mmp8 Itgam Mmp9 Try4 Commd9 Pdxk Itgb2 Cd53 Atg7 Xrcc6 Bpi Hbb-b1 Xrcc5 Cd59 Ceacam1 Np4 Ctsa Ptprc Cyfip1 Serpinb3a Cd63 Pnp Sdcbp RGD1304587 Cct2 Apaf1 Prss2 LOC100909857 Ddost LOC498300 Vamp8 Defa7 Gdi2 Anpep Plaur Serpinb12 Cct8 Defa5 Cst3 Dnajc13 Nckap1l Itgal Serpinb10 LOC100909879 Itgax Ilf2 Qsox1 Mpo Prss1 Fcgr3a LOC685953 Slc2a5 Cd36 Ctsc Rock1 Rap2b Syngr1 Tmem179b Svip Serpinb1b Ctsz Mlec Arg1 Frk Serpinb1a Cstb Psmb7 Ctsd Psmb1 Ctsb Vapa Ctsg Lrrc7 Prdx4 Gmfg C5ar1 Nme2 LOC687609 Dsn1 Lrmp Rap2c Grn Stom Dsp Cab39 Cd14 LOC100909977 LOC100909700 Atp6v0a1 LOC102554637 Ltf Psma5 Slpi Padi2 Plekho2 Rap1a Fcer1g Tollip Gsn Pkp1 Chi3l1 Psma2 Pglyrp1 Snap29 Psmd2 Commd3 Idh1 Bst1 Ptpn6 Psmc2 Fgl2 Tnfaip6 Psmd1 Psmd7 Iqgap1 Prdx6 Tspan14 Psmd3 Psmd6 Psen1 Ncstn LOC683849 Cd47 Ttr Nfkb1 Mapk1 Mapk14 Ddx3x Plac8 RGD1563818 Cotl1 Cmtm6 RT1-A2 Lpcat1 RT1-A1 Ggh Clec5a B2m LOC100125364 Glipr1 Rnaset2 Gpr84 RGD1561778 Ist1 Cpped1 Cand1 A1bg Clec4d Hexb Pkm Pgam1 Glb1 Manba Aldoa Gyg1 Aldoc Pfkl Pgm2 Pgm1 B4galt1 Aldoart2 Agl Gpi Arsb Dera Gusb Hpse Man2b1 Cd44 Atp6v1d Cda Lamp1 Ftl1 Psap RatNP-3b Gaa Svs1 Fuca2 Serpinb6b Igf2r Pygl Lrg1 RGD1306474 Magt1 Rac1 Acly Cap1 Pdap1 Doxl2 Doxl1 Cpne3 Rnase17 Rab27a Psmd11 Psmd12 Fabp5 Dynlt1 Psmd13 Psmd14 Tmem30a Lamp2 Unc13d Mif Ap2a2 Crisp3 Cfp S100a11 Aga Cfd RT1-M3-1 Serpinb3 Atp8a1 Kcmf1 Aldh3b1 Ndufc2 Serpinb6 Aprt Faf2 Cpne1 Psmc3 Diaph1 Trpm2 LOC100364500 Defa11 Fcnb Defa10 RT1-S3 Cant1 Tmem173 Cxcr2 Atp6v0c RGD1564463 Anxa2 Mgst1 Retn RT1-CE2 Dpp7 Nit2 RT1-CE3 RT1-CE4 RT1-CE7 RT1-CE5 Slco4c1 Hsp90ab1 RGD1561661 Rab3a Copb1 Cat Cd177 RT1-CE10 Hebp2 Rab7a Ptges2 Ptafr Tubb5 Creg1 Pigr Mettl7a Alox5 Kcnab2 Pygb Rab4b Ticam2 Mme Neu1 Lta4h Ms4a3 Cxcl2 Cxcl1 Epx S100a8 Cd68 Rab5b Cxcl3 Rab5c Chit1 Ampd3 Slc27a2 Dgat1 Rab6a LOC683761 LOC100364956 Atp6ap2 Tmem63a Ptprn2 Nhlrc3 Naprt1 Ano6 Pa2g4 Gm2a Dbnl Fcgr2b LOC103693683 Atad3a Serpina3m Rab9b Fcgr2a Trappc1 Tlr2 Plau Slc11a1 Kpnb1 Chrnb4 Fpr1 Arl8a Pld1 Ostf1 Ear1 Vcl Prg3 Erp44 Stk10 Sptan1 Vcp Prg2 Rab18 Ghdc LOC100910990 Slpil3 Rab10 Rab14 Slpil2 Vnn1 Rab24 Actr10 Nbeal2 Lamtor3 RT1-A Arsa Tmbim1 Dok3 Dync1h1 P2rx1 Acaa1a Acaa1b Lamtor2 Lamtor1 Apeh Ypel5 Dync1li1 Slc44a2 LOC103692716 Qpct RGD1565355 Cybb Cyba LOC361635 Actr1b RT1-M2 Hmha1 Lgals3 RT1-M5 RT1-M4 Nfam1 Ubr4 Crispld2 Pycard Stk11ip Rab3d Rbm12 Galns Gca C3ar1 Prkcd Armc8 Olfm4 Fcar Gstp1 Asah1 Mnda Bri3 Ptx3 Srp14 Tcirg1 Hmox2 Ptprj Jup Mospd2 Impdh1 Impdh2 Ap1m1 Nfasc Rnase3 LOC100360575 Rnase2 Enpp4 Sirpa Tyrobp LOC100360087 Cdk13 LOC299277 Golga7 Hvcn1 Stbd1 Dsg1 Txndc5 Dnajc5 Csnk2b Actr2 Fgr Alad Gla Dnajc3 Tnfrsf1b Arhgap9 RGD1559482 C3 RT1-M6-1 Lair1 Ppbp Atp11a Vat1 Aoc1 RT1-M6-2 Agpat2 Rhoa Eef2 Arpc5 Gsdmd Prcp Cyb5r3 Nras Rhof Rhog Ckap4 Tbc1d10c Degs1 Tom1 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA%REACTOME DATABASE ID RELEASE 66%10145918 Regulation of innate immune responses to cytosolic DNA Nlrp4 Dtx4 Tbk1 Ddx41 Nlrp4a Irf3 Trim21 Trim32 Tmem173 RHO GTPASES ACTIVATE CIT%REACTOME DATABASE ID RELEASE 66%10146123 RHO GTPases activate CIT Rhoa Rhob Rac1 Dlg4 Prc1 Rhoc Cit FORMATION OF INCISION COMPLEX IN GG-NER%REACTOME%R-RNO-5696395.1 Formation of Incision Complex in GG-NER Gtf2h1 Gtf2h2 Ddb2 Pias3 Pias1 Ddb1 Mnat1 Rbx1 Ercc5 Ercc3 Rpa1 Rpa2 Chd1l Ercc2 Ercc1 Usp45 Parp2 Sumo1 Parp1 Rpa3 Rad23a Cdk7 Rad23b Sumo3 Cul4b Ccnh Cul4a Ube2v2 Xpc Ube2n Xpa Ube2i Gtf2h3 Gtf2h5 Gtf2h4 NTF3 ACTIVATES NTRK3 SIGNALING%REACTOME%R-RNO-9034013.1 NTF3 activates NTRK3 signaling Ntrk3 Ntf3 REMOVAL OF THE FLAP INTERMEDIATE%REACTOME DATABASE ID RELEASE 66%10144734 Removal of the Flap Intermediate Rpa1 Slc25a16 Rpa3 Fen1 Rpa2 Prim2 Pola2 Prim1 Pold2 Pcna Pold1 Pold4 THE PROTON BUFFERING MODEL%REACTOME%R-RNO-167827.1 The proton buffering model Ucp2 Ucp3 LOC100909612 Slc25a14 Ucp1 POTASSIUM TRANSPORT CHANNELS%REACTOME%R-RNO-1296067.1 Potassium transport channels Kcnj16 RUNX2 REGULATES OSTEOBLAST DIFFERENTIATION%REACTOME%R-RNO-8940973.1 RUNX2 regulates osteoblast differentiation Runx2 BUTYRATE RESPONSE FACTOR 1 (BRF1) BINDS AND DESTABILIZES MRNA%REACTOME%R-RNO-450385.1 Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Dcp2 Exosc3 Akt1 Mapkapk2 LOC100911537 Xrn1 Dcp1a Exosc9 Exosc2 Exosc1 Exosc4 Exosc7 Exosc5 Ywhab NEUROTRANSMITTER CLEARANCE%REACTOME%R-RNO-112311.1 Neurotransmitter clearance Maoa Ache Slc22a1 Slc22a2 Aldh2 Comt Slc6a4 Slc6a3 Bche Lrtomt RUNX3 REGULATES YAP1-MEDIATED TRANSCRIPTION%REACTOME DATABASE ID RELEASE 66%10146278 RUNX3 regulates YAP1-mediated transcription Yap1 Tead2 Tead1 ESTABLISHMENT OF SISTER CHROMATID COHESION%REACTOME DATABASE ID RELEASE 66%10145970 Establishment of Sister Chromatid Cohesion LOC100910252 Stag1 Esco1 Pds5b Pds5a Cdca5 Rad21 Smc1a Stag2 Smc3 Esco2 PRC2 METHYLATES HISTONES AND DNA%REACTOME%R-RNO-212300.1 PRC2 methylates histones and DNA Eed LOC100910200 H2afx Hist1h4b Phf19 LOC684841 Hist1h2bh Dnmt1 LOC100912290 Rbbp7 Hist1h2ail1 Hist1h4m LOC102549173 LOC103690002 LOC100910152 Dnmt3a LOC100912338 Hist1h3c H2afb3 Hist1h3f Dnmt3b Hist2h4 LOC684819 Hist1h3a H2afj Hist2h2aa3 Hist1h2bq Hist2h2aa2 Mtf2 Phf1 LOC100364835 LOC684762 Hist1h2bo Hist1h2bcl1 Hist2h3c2 Hist1h2bk H3f3b Jarid2 Hist1h2bg Ezh2 LOC680097 LOC684797 LOC100912418 Hist1h2ba Hist3h2bb Aebp2 FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION%REACTOME%R-RNO-434316.1 Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Plcb1 Plcb3 Ffar1 Gnaq Gna11 Gna14 Gna15 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION%REACTOME%R-RNO-381340.1 Transcriptional regulation of white adipocyte differentiation Rxra Pparg INTERLEUKIN-20 FAMILY SIGNALING%REACTOME%R-RNO-8854691.1 Interleukin-20 family signaling Stat5a Jak3 Il22 Il24 Il19 Stat1 Il22ra1 Jak1 Stat2 Stat3 Il10rb Ptpn11 Il22ra2 Il20ra Il20rb Tyk2 Ifnl3 Il20 Ifnlr1 RHO GTPASE EFFECTORS%REACTOME DATABASE ID RELEASE 66%10144888 RHO GTPase Effectors Cenpn Zwilch Cenpl Cenpo Klc1 Dync1li2 Cenpt Cenpu Abi1 Bub3 Bub1 Abi2 Potef Spdl1 Kntc1 Dync1i2 Mad1l1 Rtkn Myh9 Nck1 Cenpk Cenph Cenpi Rock2 Klc4 Cenpf Kdm1a Cenpe Cenpm Klc2 Ahctf1 Klc3 Ndel1 Rcc2 Noxo1 Arpc1b LOC100909750 Actb Pafah1b1 Rhpn1 Ncf1 Ncf4 Rhpn2 Ppp1r12a LOC100361515 Mis12 Dynll2 Ndc80 Cenpc Noxa1 Ppp1r14a Cenpa Dync1i1 Daam1 Srgap2 LOC100909840 Ptk2 Actg1 Cyfip2 Birc5 Nckap1 Taok1 Nup85 Cdh1 Rhob Dlg4 Rhoc Myh14 Nup98 Myh11 Nup107 Prc1 Cit Cdca8 Flna Pkn1 Evl Cyfip1 Tax1bp3 Pkn2 Pkn3 Brk1 Cdc25c Rangap1 Fmnl1 Ppp1cb Baiap2 Ppp1cc LOC100909468 Aurkb Limk1 Sec13 Nf2 Xpo1 Pak2 Pak3 Pak1 Rac2 Wasl LOC100911204 Nckap1l Spc24 Spc25 Nox3 Nox1 Abl1 Itgb3bp Sgol2 Rhod Wasf1 Arpc4 Ppp2r5e Rock1 Incenp Rhoq Ktn1 Arpc3 Nsl1 LOC102551071 B9d2 Cdc20 Kif2a Kif2c Kif2b Men1 Bub1b Kif18a Ppp2r5c Ppp2r5a Nckipsd LOC100361457 Ppp2r5b Zwint Mylk Dsn1 Kif5b Mad2l1 Kif5a Casc5 Actr3 Lin7b Was Clasp2 Ercc6l Ctnna1 Nuf2 Pik3c3 Ncoa2 Clasp1 LOC679582 Iqgap3 Dvl1 Mkl1 Pik3r4 Pdpk1 Mapre1 Cdc42 LOC100911597 Pmf1 Dvl2 Dvl3 Pfn1 Pfn2 Ckap5 Scai Ska2 Wipf1 Wipf2 Wipf3 Iqgap1 Sgol1 Zw10 Srf Ska1 Nup43 Nup133 Rac1 Nup37 Diaph1 Ranbp2 Src Ppp2cb Ywhah Ppp2ca Ywhag Ppp2r1a Sfn Ywhaz Ywhab Ywhaq Ywhae Ppp2r1b Mapk1 Hist1h2bo Dync1h1 Hist1h2bcl1 Hist2h3c2 Hist1h2bk H3f3b Dync1li1 Cybb Cyba LOC100910200 H2afx Hist1h4b LOC684841 Hist1h2bh LOC100912290 Hist1h2ail1 Hist1h4m LOC102549173 LOC103690002 LOC100910152 LOC100912338 Hist1h3c H2afb3 Hist1h3f Hist2h4 LOC684819 Hist1h3a H2afj Hist2h2aa3 Hist1h2bq Hist2h2aa2 LOC100364835 LOC684762 Actr2 Rhoa Arpc5 Hist1h2bg LOC680097 LOC684797 Rhog LOC100912418 Hist1h2ba Hist3h2bb Grb2 HDL CLEARANCE%REACTOME%R-RNO-8964011.1 HDL clearance Scarb1 Cubn Amn Hdlbp Apoa1 BIOSYNTHESIS OF DHA-DERIVED SPMS%REACTOME DATABASE ID RELEASE 66%10146302 Biosynthesis of DHA-derived SPMs Hpgd LOC100361547 Gpx4 Cyp3a23/3a1 Cyp3a73 Cyp2d5 Cyp2c7 Alox12 Cyp2e1 Ltc4s Gstm4 Cyp2d4 Cyp3a18 Alox5 Cyp1a1 LOC100910877 Cyp2d2 Ptgs2 Ephx2 Cyp1a2 Alox15 Cyp2d3 Lta4h Cyp2c6v1 IRS-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%R-RNO-2428928.1 IRS-related events triggered by IGF1R Pik3r1 Pik3r2 Fgf23 Fgf22 Fgf4 Fgf1 Fgf3 Tlr9 Fgf6 Fgf5 Fgf20 Gab1 Pde3b Igf2 Igf1 Fgf16 Pik3c3 Fgf17 Irs2 Fgf10 Fgf9 Fgfr2 Fgf7 Fgf2 Fgf8 Pik3r4 Fgfr3 Trib3 Pdpk1 Fgfr1 Fgfr4 Pik3cb Ptpn11 Fgf19 Them4 Irs1 Frs2 Sos1 Akt2 Grb2 INSULIN RECEPTOR SIGNALLING CASCADE%REACTOME DATABASE ID RELEASE 66%10144875 Insulin receptor signalling cascade Pik3r1 Pik3r2 Fgf23 Fgf22 Fgf4 Fgf1 Fgf3 Tlr9 Fgf6 Fgf5 Fgf20 Gab1 Pde3b Fgf16 Pik3c3 Fgf17 Irs2 Fgf10 Fgf9 Fgfr2 Fgf7 Fgf2 Fgf8 Fgfr3 Pik3r4 Trib3 Pdpk1 Fgfr1 Mapk1 Fgfr4 Grb10 Pik3cb Ptpn11 Insr Ins1 Ins2 Fgf19 Them4 Irs1 Frs2 Sos1 Shc1 Akt2 Grb2 P2Y RECEPTORS%REACTOME%R-RNO-417957.1 P2Y receptors P2ry6 Lpar6 P2ry4 P2ry1 Gpr17 Lpar4 P2ry12 P2ry2 P2ry10 P2ry13 REGULATION OF ORNITHINE DECARBOXYLASE (ODC)%REACTOME DATABASE ID RELEASE 66%10145465 Regulation of ornithine decarboxylase (ODC) Nqo1 Psmc6 Oaz3 Psmb10 Oaz1 Oaz2 G6pc Psmb8 Psmb9 Psmb4 Psmb11 Psmb5 Psmf1 Psmb6 Psmd4 Psmb2 Psmd5 Psmd8 Psmb7 Psmd9 Psmb1 Psmb3 Azin1 Psma8 Psmd11 Psmd12 Psmd13 Psmd14 Psma5 Psma2 Psmc3 Psmc5 Psmd2 Psma1 Psma4 Psmc1 Psma3 Psmc4 Psmc2 Psma6 Psme1 Odc1 Psmd1 Psme2 Psmd7 Psmd3 Psmd6 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS%REACTOME%R-RNO-174417.1 Telomere C-strand (Lagging Strand) Synthesis Rfc1 Rfc2 Rpa3 Pole2 Pole4 LOC100911727 Pole Pold2 Pcna Pold1 Pold4 Rpa1 Slc25a16 Rpa2 Fen1 Prim2 Pola2 Prim1 Rfc5 Rfc4 Rfc3 Lig1 PROTON-COUPLED MONOCARBOXYLATE TRANSPORT%REACTOME DATABASE ID RELEASE 66%10145649 Proton-coupled monocarboxylate transport Bsg Slc16a3 Slc16a7 Slc16a8 Slc16a1 INSULIN EFFECTS INCREASED SYNTHESIS OF XYLULOSE-5-PHOSPHATE%REACTOME%R-RNO-163754.1 Insulin effects increased synthesis of Xylulose-5-Phosphate Tkt Taldo1 TRANSPORT OF NUCLEOSIDES AND FREE PURINE AND PYRIMIDINE BASES ACROSS THE PLASMA MEMBRANE%REACTOME%R-RNO-83936.1 Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane Slc28a2 Slc28a1 Slc28a3 Slc29a3 Slc29a2 Slc29a4 LOC100911721 Slc29a1 LOC691960 METHYLATION%REACTOME DATABASE ID RELEASE 66%10144922 Methylation N6amt1 Nnmt Mat2a As3mt Tpmt Mtrr Trmt112 Gsto1 Mtr Comt Mat1a Cyp1a2 Mat2b LOC100363915 Ahcy GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION%REACTOME%R-RNO-381676.1 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Rap1a Gnb3 Gnb5 Kcnc2 Gnb2 Gnb1 Gng13 Gng12 Gng11 Prkaca Prkacb Itpr1 Kcns3 Rapgef4 Itpr3 LOC100912034 Gnb4 Glp1r Gcg Gng4 Gngt2 Gng5 Gngt1 Gng10 Gng8 Gng3 CHYLOMICRON ASSEMBLY%REACTOME DATABASE ID RELEASE 66%10145238 Chylomicron assembly P4hb Sar1b Apob Apoa1 Apoc2 Apoe Apoa2 Mttp MYD88-INDEPENDENT TLR4 CASCADE%REACTOME%R-RNO-166166.1 MyD88-independent TLR4 cascade Map2k7 Ripk2 Tbk1 Map2k6 Ager Dusp3 Irf3 Map2k4 Map3k8 Dusp4 Nfkbib Traf6 Cul1 Vrk3 Rps6ka2 Rps6ka1 App Rps6ka3 Rps6ka5 LOC100912585 Tab1 Dusp7 Dusp6 Rela Atf1 Atf2 Map3k7 Irak2 Tlr4 Ikbke Tank Traf3 Nfkbia LOC100910771 Ube2n Jun Ppp2cb Ppp2ca Skp1 Ppp2r1a Ticam2 Nfkb2 Cd14 Nfkb1 Mapk9 Mapk8 Fos S100b Mapk7 Dhx9 Fbxw11 Chuk Ppp2r1b Mapkapk3 Btrc Mapkapk2 Mapk1 Nkiras1 LOC100362142 Nod1 Ptpn11 Nod2 Nkiras2 Creb1 Tab2 Tab3 LOC100912618 Ube2v1 Ikbkb Mapk14 Myd88 Tnip2 Mapk11 Mapk10 HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145724 Highly calcium permeable postsynaptic nicotinic acetylcholine receptors Chrnb4 Chrna4 Chrna5 Chrna9 Chrna6 Chrnb2 Chrna7 Chrnb3 Chrna2 Chrna3 Chrna1 G ALPHA (12 13) SIGNALLING EVENTS%REACTOME%R-RNO-416482.1 G alpha (12 13) signalling events Rock2 Gng10 Arhgef6 Arhgef5 Arhgef39 Arhgef7 Rock1 Arhgef37 Arhgef38 Arhgef33 Prex1 Adra1a Tbxa2r Itsn1 Arhgef2 LOC102556447 Arhgef4 Arhgef3 Plekhg5 Arhgef19 Arhgef18 Plekhg2 Kalrn Adra1d Plxnb1 LOC100912512 Gna12 Vav2 Gna13 Vav1 Arhgef11 Akap13 Arhgef16 Arhgef15 Net1 Ect2 Arhgef26 Fgd2 Mcf2l Tiam1 Tiam2 Vav3 Gnb3 Gnb5 Gnb2 Fgd3 Gnb1 Gng13 Sos2 Gng12 Ngef Gng11 Rhoa LOC100912034 Gnb4 Gng4 Gngt2 Sos1 Gng5 Rhob Gngt1 Gng8 Rhoc Gng3 EPHRIN SIGNALING%REACTOME%R-RNO-3928664.1 Ephrin signaling Src Arhgef7 Fyn Ephb1 Ephb2 Sdcbp Rac1 Pak2 Pak3 Pak1 Ephb4 Ephb3 Efnb2 Efnb1 Efnb3 Myl12a Nck2 METABOLISM OF NITRIC OXIDE%REACTOME DATABASE ID RELEASE 66%10145396 Metabolism of nitric oxide Nosip Nos3 Dnm2 Ddah2 Zdhhc21 Nostrin Ddah1 Wasl Spr Cygb LOC103692716 Akt1 SUMOYLATION OF UBIQUITINYLATION PROTEINS%REACTOME%R-RNO-3232142.1 SUMOylation of ubiquitinylation proteins Nup93 Nup43 Nup98 Nup133 Trim27 Mdm2 Nup107 Vhl Aaas Pias1 Nup155 Nup210 Npap60 Nup35 Nup88 Nup37 Pias4 Nupl2 Pml Pias2 Nupl1 Nup85 Nup153 Sumo1 Tpr Rae1 Nup54 Ube2i Pom121 Nup205 Ranbp2 Nup62 SIGNALING BY TGF-BETA RECEPTOR COMPLEX%REACTOME%R-RNO-170834.1 Signaling by TGF-beta Receptor Complex Smad3 Ccnt2 Smad2 Pard6a Nedd8 Fkbp1a Strap Usp9x Sp1 Ube2d1 Skil Rbl1 F11r Ncor2 Cdk9 Mtmr4 E2f4 Men1 Zfyve9 Hdac1 Arhgef18 Tgif2 Tgif1 Atp1b4 Trim33 Pmepa1 Ccnk Ube2d3 Pard3 Bambi Wwtr1 Tfdp1 Prkcz Tfdp2 Furin Stub1 Smurf1 Parp1 Tgfbr1 Ube2m E2f5 Cbl Hdac1l Snw1 Tgfbr2 Cgn Rhoa Tgfb1 SIGNALING BY HEDGEHOG%REACTOME%R-RNO-5358351.1 Signaling by Hedgehog Psmc6 Psmb10 Psmb8 Psmb9 Psmb4 Psmb11 Psmb5 Psmf1 Psmb6 Psmd4 Psmb2 Rbx1 Psmd5 Psmd8 Psmd9 Psmb3 Psma8 Psmd11 Psmd12 Psmd13 Psmd14 Disp2 Adcy8 Rpgrip1l Adcy9 Adcy5 Adcy4 Adcy7 Adcy6 Prkar1b Prkar1a Smo Wdr35 Evc2 Kif3a Ift88 Psmc3 Skp1 Btrc Prkaca Prkacb Vcp Cul1 Smurf1 Mks1 Cdc73 Csnk1a1 RGD1564313 Dzip1 Sufu G6pc Dhh Cdon Shh Ptch1 Efcab7 Spop Iqce Spopl Ofd1 Ulk3 Psmb7 Boc Psmb1 Gli1 Gli3 Gli2 Adcy3 Prkar2b Prkar2a Ihh Ift122 Os9 Evc RGD1559714 Wdr19 Ttc21b RGD1563667 Erlec1 P4hb Psma5 Psma2 Psmc5 Arrb1 Psma1 Psmd2 Ift52 Psma4 Kif7 Psmc1 Arrb2 Psma3 Ift57 Gas1 Psmc4 Psma6 Hhip Psmc2 Gas8 Psme1 LOC689173 Psmd1 Psme2 Psmd7 Adrbk1 Gpr161 Scube2 Ift140 Sel1l Psmd3 Tulp3 Psmd6 GABA A (RHO) RECEPTOR ACTIVATION%REACTOME DATABASE ID RELEASE 66%10145776 GABA A (rho) receptor activation Gabrr1 Gabrr3 Gabrr2 SYNTHESIS OF PIPS IN THE NUCLEUS%REACTOME%R-RNO-8847453.1 Synthesis of PIPs in the nucleus Tmem55b Pip4k2b Pip4k2c TP53 REGULATES METABOLIC GENES%REACTOME DATABASE ID RELEASE 66%10144779 TP53 Regulates Metabolic Genes Akt1 Gpi Ywhah Ywhag Sfn Ywhaz Sesn2 Txnrd1 Sesn1 RragB Lamtor3 Ywhab Prkab1 Sesn3 Ywhaq Ywhae Prkab2 Gsr Mtor Prdx1 Ddit4 Rheb Lamtor2 Prkag3 Lamtor1 Rptor Lamtor4 LOC502894 Tsc1 Lamtor5 Txn1 Mlst8 Prkaa1 Tsc2 Rraga Prkaa2 Rragc Akt3 Rragd Slc38a9 Akt2 VLDL ASSEMBLY%REACTOME%R-RNO-8866423.1 VLDL assembly P4hb Apob Apoc1 LOC100910181 Apoc4 Mttp GLYCOSPHINGOLIPID METABOLISM%REACTOME%R-RNO-1660662.1 Glycosphingolipid metabolism Hexb Hexa Psap Asah1 Neu4 Neu2 Gltp B4galnt1 Neu3 Cerk Enpp7 Neu1 Gba Arsa Galc Asah2 Arsi Smpd1 Ctsa Arse Cptp Arsg Smpd2 Gla Esyt3 Smpd3 Arsk Glb1l Sts Esyt2 Smpd4 Arsb Gba2 Sumf2 Sumf1 B3galnt1 Ugt8 Glb1 Ugcg Gm2a PCP CE PATHWAY%REACTOME%R-RNO-4086400.1 PCP CE pathway Psmc6 Psmb10 Psmb8 Psmb9 Psmb4 Psmb11 Psmb5 Psmf1 Psmb6 Rac1 Psmd4 Psmb2 Psmd5 Psmd8 Psmd9 Psmb3 Psma8 Psmd11 Psmd12 Psmd13 Psmd14 Ap2a2 Smurf1 LOC100361515 Psmc3 Rac2 Daam1 Pard6a G6pc Wnt5b Wnt5a Prickle1 Fzd1 Cltc Psmb7 Cltb Psmb1 Fzd3 Clta Fzd2 Fzd4 Fzd7 Fzd6 Prkcb Ap2s1 Wnt1 Wnt11 Wnt4 Ap2a1 Ror1 Ror2 Ap2m1 Psma5 Dvl1 Psma2 Psmc5 Psma1 Psmd2 Psma4 Dvl2 Arrb2 Dvl3 Psmc1 Rhoa Psma3 Pfn1 Psmc4 Psmc2 Prkca Psma6 Psme1 Psmd1 Psme2 Psmd7 Psmd3 Psmd6 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA%REACTOME%R-RNO-1234176.1 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Psmc6 Psmb10 Psmb8 Vhl Psmb9 Psmb4 Psmb11 Psmb5 Psmf1 Psmb6 Psmd4 Psmb2 Rbx1 Psmd5 Psmd8 Psmd9 Psmb3 Psma8 Psmd11 Psmd12 Psmd13 Psmd14 Egln2 Tceb2 Tceb1 Cul2 Hif1a Limd1 Psmc3 Epas1 Hif3a Egln3 Ajuba G6pc Ube2d1 Psmb7 Psmb1 Ube2d3 Psma5 Psma2 Psmc5 Psmd2 Psma1 Psma4 Psmc1 Psma3 Psmc4 Psmc2 Psma6 Psme1 Psmd1 Psme2 Psmd7 Psmd3 Psmd6 OREXIN AND NEUROPEPTIDES FF AND QRFP BIND TO THEIR RESPECTIVE RECEPTORS%REACTOME%R-RNO-389397.1 Orexin and neuropeptides FF and QRFP bind to their respective receptors Npff Npffr2 RGD1560028 Hcrt Npffr1 Qrfp LOC100909783 Hcrtr1 Qrfpr Hcrtr2 REGULATION OF TP53 EXPRESSION AND DEGRADATION%REACTOME%R-RNO-6806003.1 Regulation of TP53 Expression and Degradation Usp7 Mdm2 Akt1 Ppp2r5c Ppp2cb Ppp2ca Ppp2r1a Ccna2 Ccna1 Rffl Ccng1 Phf20 Atm Rictor Mtor Usp2 Cdk2 Daxx LOC100910954 Cdk1 Ppp2r1b Mdm4 Mlst8 Chek2 Pdpk1 Rnf34 Mapkap1 Sgk1 Akt3 Akt2 METABOLISM OF SEROTONIN%REACTOME%R-RNO-380612.1 Metabolism of serotonin Maoa Aldh2 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION%REACTOME DATABASE ID RELEASE 66%10145589 Adrenaline,noradrenaline inhibits insulin secretion Adcy5 Adra2a Gnai2 Adcy6 Adra2c Gnb3 Gnb5 Gnb2 Gnb1 Gng13 Gng12 Gng11 LOC100912034 Gnb4 Gng4 Gnai1 Gngt2 Gng5 Gngt1 Gng10 Gng8 Gng3 DECTIN-1 MEDIATED NONCANONICAL NF-KB SIGNALING%REACTOME%R-RNO-5607761.1 Dectin-1 mediated noncanonical NF-kB signaling Psmc6 Psmb10 Psmb8 Psmb9 Psmb4 Psmb11 Psmb5 Psmf1 Psmb6 Psmd4 Cul1 Psmb2 Psmd5 Psmd8 Psmd9 Psmb3 Psma8 Psmd11 Psmd12 Psmd13 Psmd14 Ube2m Psmc3 G6pc Psmb7 Psmb1 Skp1 Nfkb2 Psma5 Fbxw11 Chuk Btrc Psma2 Psmc5 Psmd2 Uba3 Psma1 Map3k14 Psma4 Relb Psmc1 Psma3 Psmc4 Psmc2 Psma6 Psme1 Psmd1 Psme2 Psmd7 Psmd3 Psmd6 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME DATABASE ID RELEASE 66%10145920 NOTCH2 Activation and Transmission of Signal to the Nucleus Notch2 Mdk Dll4 ESTROGEN-DEPENDENT GENE EXPRESSION%REACTOME%R-RNO-9018519.1 Estrogen-dependent gene expression Yy1 Med1 RGD1565904 Polr2g Polr2h Polr2e Polr2f Polr2j Polr2k Polr2d Polr2i Polr2b Kdm1a Polr2c Atf2 Polr2a Cited1 Hist1h2bo Hist1h2bcl1 Nr5a2 Hist2h3c2 LOC100912534 Gtf2f1 Gtf2f2 Hist1h2bk Kdm4b H3f3b Carm1 Greb1 Usf1 Gtf2a1 Foxa1 Bmyc LOC103692716 Ptges3 Hdac1l Prmt1 Zfp217 Ptges3l1 Esr1 Pou2f1 Cbfb Tle3 Gata3 Fkbp4 Ddx5 Erbb4 Crebbp Nrip1 Pgr Ncoa1 Tbp Runx1 LOC100910200 H2afx Hist1h4b LOC684841 Hist1h2bh Hsp90ab1 LOC100912290 Sp1 Hist1h2ail1 Hist1h4m LOC102549173 Cdk9 LOC103690002 LOC100910152 LOC100912338 Hist1h3c Hdac1 Jun H2afb3 Hist1h3f Hist2h4 LOC684819 Hist1h3a H2afj LOC100911822 Hist2h2aa3 Hist1h2bq Hist2h2aa2 LOC100364835 LOC684762 Fos Ncoa2 Hist1h2bg LOC680097 LOC684797 LOC100912418 Hist1h2ba Hist3h2bb TRIGLYCERIDE METABOLISM%REACTOME%R-RNO-8979227.1 Triglyceride metabolism Fabp3 Fabp6 Fabp1 Fabp4 Gk Fabp12 Pnpla5 Fabp7 Fabp5 Dgat1 Fabp2 Gpam Mogat1 Fabp9 Lpin2 Mogat2 Lpin3 Lpin1 RGD1562200 Dgat2 Gk2 Plin3 Gpat2 Gpd2 Agmo P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME%R-RNO-372708.1 p130Cas linkage to MAPK signaling for integrins Fn1 Src Tln1 Crk Vwf Rap1a Apbb1ip Fgb Bcar1 Fgg Fga Itga2b Ptk2 PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145719 Presynaptic nicotinic acetylcholine receptors Chrnb4 Chrna4 Chrna5 Chrna6 Chrnb2 Chrnb3 Chrne Chrna2 Chrnd Chrna3 Chrna1 PRE-MRNA SPLICING%REACTOME DATABASE ID RELEASE 66%10144828 pre-mRNA splicing Cwc27 Cwc25 Cwc22 Snrpf Wdr33 Ppie RGD1565904 Isy1 Polr2g Polr2h Polr2e Polr2f Polr2j Polr2k Polr2d Polr2i Polr2b Polr2c Polr2a Xab2 LOC100912534 Prpf19 Srsf3 Ccar1 Cdc5l Upf3b U2af2 LOC102548514 Cd2bp2 Papola Srsf6 Elavl1 Srsf7 Ppil6 Prpf38a Srsf4 Srsf5 Srsf2 Hnrnph1 Ppih LOC100359574 Ppil1 Ppil3 Elavl2 Srsf9 Ppil4 Dhx38 LOC100911822 Fblim1 Clp1 Aqr Hnrnph2 Cwc15 Cherp Magoh Hnrpd Ncbp2 Srsf1 LOC100363335 Ctnnbl1 Ppwd1 LOC500684 Ncbp1 LOC680519 Dhx9 Ybx1 LOC100910750 Nhp2l1 Cstf2t Eif4a3 Sympk Bud31 Hnrnpul1 Txnl4a LOC100910660 Hnrnpk Srrm1 Hnrnpu Hnrnpr Wbp4 Usp39 Hnrnpl Snrpa Hnrnpm Hnrnpf Cdc40 Snrpc Hnrnpa2b1 Snrpb Rnps1 Dhx16 Dhx15 Sugp1 Prpf40a Sart1 Snrpb2 Magohb Phf5a Rbm8a Ddx23 Pcf11 Fip1l1 Hnrnpa0 U2surp Nudt21 Snrpd1 Eftud2 LOC100364748 Snrpd2 Snrpd3 Rbm5 Tra2b Sf3b2 Sf3b4 Sf3b3 Pqbp1 Sf3b5 Cstf2 Rbm22 Lsm8 Puf60 Wbp11 Lsm7 U2af1l4 Gtf2f1 Lsm6 Gtf2f2 Lsm4 Lsm3 Lsm5 Cpsf7 Cpsf2 Cpsf3 Cpsf4 Lsm2 Rbm17 Snw1 Cstf1 Snrnp200 Cpsf1 Smptb Gpkow Plrg1 LOC679753 Prpf6 Sf3a3 Sf3b1 Prpf8 Prpf4 Ddx5 Ddx46 Sf3a1 Prpf31 Ddx42 Bcas2 Prpf3 Sf3a2 Crnkl1 LOC100360750 Syf2 Fus Smndc1 Prcc Rbmx LOC100359916 Snrpa1 Snrnp70 BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS%REACTOME DATABASE ID RELEASE 66%10145554 Beta-oxidation of very long chain fatty acids Acot6 Acot4 Acaa1a Acot8 Acaa1b Acox1 Ehhadh Eci3 Hsd17b4 Mlycd Abcd1 PKMTS METHYLATE HISTONE LYSINES%REACTOME DATABASE ID RELEASE 66%10146041 PKMTs methylate histone lysines Rela Hist2h3c2 Setd6 Setd7 Setd8 Setd2 Setd3 Ash1l Suv39h1l1 Rbbp5 Eed LOC100909949 Whsc1 Atf7ip Hist1h4b Prdm9 Wdr5 Kmt2a LOC684841 Smyd2 Setdb1 LOC100911180 LOC100912290 Suv420h2 Rbbp7 LOC686349 Hist1h2ail1 Suv420h1 Hist1h4m Mecom LOC102549173 Ehmt2 Whsc1l1 Ehmt1 Hist1h3c Hist1h3f Hist2h4 LOC684819 Hist1h3a Prdm16 Nsd1 Suv39h1 Suv39h2 LOC100910833 Ash2l Dot1l LOC684762 Dpy30 Nfkb2 Nfkb1 Ezh2 LOC680097 LOC100912418 Aebp2 CHROMATIN MODIFYING ENZYMES%REACTOME%R-RNO-3247509.1 Chromatin modifying enzymes Kdm1a Phf20 Actl6a Mcrs1 Rps2 Setd6 Setd7 Setd8 Setd2 Setd3 Ash1l Suv39h1l1 Rbbp5 Jmjd6 Actl6b Hist1h2aa Smarce1 Pax3 Pbrm1 Arid1b Arid1a Cdk4 Brwd1 Smarcd1 Msl3l2 Smarcd2 Smarcd3 Brpf3 Ccnd1 Kdm2a Brpf1 Brd1 Kdm1b LOC100911453 RGD1310212 Wdr77 Kat6a Ing4 Ing5 Nfkb2 Nfkb1 Prmt3 Padi6 Prmt5 Prmt6 Prmt7 Rela Atf2 Hist1h2bo Kat7 Kansl3 Hist1h2bcl1 Hist2h3c2 Jade1 Hist1h2bk Jade3 Hat1 Kdm4b Carm1 Kdm4a Jade2 Kdm4d Kdm5a Kdm6b Kdm5d Smarca4 Kdm4dl1 Prmt1 Smarca2 LOC100911617 Kat8 Kdm8 Msl3 Kdm3b Kdm3a Arid2 Ogt Smarcc1 Smarcc2 Padi3 Coprs Smarcb1 Padi4 Msl1 Padi1 Ncoa1 Msl2 Meaf6 LOC100909949 Eed Whsc1 LOC100910200 Atf7ip H2afx Hist1h4b Prdm9 Wdr5 Kmt2a LOC684841 Hist1h2bh Smyd2 Setdb1 LOC100911180 LOC100912290 Suv420h2 Rbbp7 LOC686349 Hist1h2ail1 Suv420h1 Hist1h4m LOC102549173 Mecom LOC103690002 Ehmt2 LOC100910152 Whsc1l1 Dnmt3a Ehmt1 LOC100912338 Hist1h3c H2afb3 Hist1h3f Hist2h4 LOC684819 Hist1h3a H2afj Prdm16 Nsd1 Hist2h2aa3 Suv39h1 Hist1h2bq Suv39h2 Hist2h2aa2 LOC100910833 Ash2l Dot1l LOC100364835 Dpy30 LOC684762 Padi2 Ncoa2 Hist1h2bg Ezh2 LOC680097 LOC684797 LOC100912418 Hist1h2ba Hist3h2bb Aebp2 LGI-ADAM INTERACTIONS%REACTOME%R-RNO-5682910.1 LGI-ADAM interactions Adam11 Stx1a Cacng8 Cacng2 Cacng3 Lgi4 Cacng4 Lgi3 Stx1b Lgi1 Dlg4 Adam23 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION%REACTOME DATABASE ID RELEASE 66%10145151 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7 8 or 9 activation Map2k7 Ripk2 Map2k6 Ager Dusp3 Map2k4 Map3k8 Dusp4 Peli3 Nfkbib LOC100912399 Peli2 Map3k1 Traf6 Cul1 Vrk3 Rps6ka2 Rps6ka1 App Rps6ka3 Rps6ka5 Tlr9 LOC100912585 Tab1 Dusp7 Dusp6 Rela Atf1 Atf2 Map3k7 Peli1 Irak2 Nfkbia LOC100910771 Ube2n Jun Ppp2cb Ppp2ca Skp1 Ppp2r1a Nfkb2 Nfkb1 Mapk9 Tlr7 Mapk8 Tlr8 Fos S100b Irak4 Mapk7 Dhx9 Fbxw11 Chuk Ppp2r1b Ecsit Mapkapk3 Btrc Mapkapk2 Mapk1 Nkiras1 LOC100362142 Nod1 Nod2 Nkiras2 Creb1 Tab2 Tab3 LOC100912618 Ube2v1 Ikbkb Mapk14 Myd88 Tnip2 Mapk11 Mapk10 METHIONINE SALVAGE PATHWAY%REACTOME DATABASE ID RELEASE 66%10145821 Methionine salvage pathway Enoph1 Mtap Mri1 Adi1 METABOLISM OF LIPIDS%REACTOME%R-RNO-556833.1 Metabolism of lipids Bche Ache Ncor2 Mtmr4 Smarcd3 Ctsa LOC498300 Vapa Ndufab1 Ppapdc2 Pten Ptgds Pla2g6 Pla2g3 LOC683884 Pla2g5 Pitpnb Helz2 Sc5d Pla2g16 Abcd1 Dpep3 Pla2g15 Dpep1 Pla2g10 Acot6 LOC103689982 Acot4 Lhb Acot8 Nsdhl Acox1 Osbpl5 Osbpl8 Ehhadh Osbpl3 Eci3 Osbpl6 Hsd17b4 Osbpl9 Mlycd Fam73b Osbpl7 Cyp19a1 Fdx1l Ppap2a Sacm1l Prkab2 Ppap2b Slc22a5 Awat1 Awat2 Msmo1 Agps Cpt1b Alpp Alpi Cpt1a Acat2 Acat1 Fig4 LOC100911154 Cpne6 Acp6 LOC100910957 Cpne7 Mcat Cers4 Cers3 Mvd Agk Acot11 Slc25a17 Cers6 Cyp4f17 Tmem86b Lclat1 Acot13 RGD1564865 Tmem55b Slc25a20 Pip4k2b Cga Pip4k2c Cyp4f18 Pik3r5 Bmx Aacs Etnppl Tbxas1 Cept1 Pik3r3 Pik3r6 Cers1 Acer2 Acer1 Acer3 Pi4kb Cyp51 Mut Cers2 Inpp5d Inpp5e Ppt1 Ppt2 Ncoa6 Neu4 Gdf1 Neu2 Slc21a4 Inpp5f Bzrap1 Gltp Tnfaip8l3 B4galnt1 Dgat2l6 Neu3 Cerk Tnfaip8l1 Abcb11 Enpp7 Inpp5j Gba Tnfaip8 Galc Tnfaip8l2 Asah2 Stard3nl Vapb Rufy1 Ormdl1 Acox3 Ptdss2 Acox2 Srd5a3 Cdipt Aldh3a2 Sin3a Sin3b Cyp4f6 Ormdl2 Mapkapk2 LOC317456 Ppap2c Prkaa2 Osbpl10 Cbr1 Tspo Crls1 LOC100912391 Cpt2 Cyp24a1 Mcee Srd5a1 Srd5a2 Pmvk Srebf1 Pik3c2a Pik3c2b Srebf2 Pik3c2g Cds2 Hmgcll1 Cyp4a2 Pla2r1 Sqle Cyp4a1 Ptgis Tpte2 Pla2g4e Pla2g4b Lgmn Pla2g4d Inpp4a Rxra Aloxe3 Cyp4a8 Inpp4b LOC100912469 Pctp Pla2g4a Cds1 Cbr4 Acot7 Acot9 Pla2g4c Acot2 Cyp2j10 Acot5 Fdft1 Acss3 Nr1h4 Enpp6 Cyp1b1 Mbtps1 Cidec Tecr Mbtps2 Sgpl1 Echs1 Nudt7 Sbf1 Ptpn13 Hdac3 LOC100365676 Hsd17b3 Hsd17b8 Csnk2a2 Acsbg1 Hsd17b1 Hsd17b2 Pla2g12a Far2 Far1 Csnk2a1 Stard7 Stard6 Acoxl Stard3 Fa2h RGD1562948 Gc Acsbg2 Alox5ap Sptssb Lpcat4 Sptssa Eci1 Stard4 Stard5 Lpcat1 Plbd1 Abhd4 Akr1c12l1 Lipi Mid1ip1 Baat Cyp46a1 Lpcat3 Lpcat2 Fitm1 Fitm2 Hpgds Gnpat Akr1c19 Vac14 Abhd3 Thrsp Tbl1x Hsd3b Akr1c13 Akr1c14 LOC681458 Akr1c12 Pla2g4cl1 Fasn Chat Csnk1g2 Amacr Hexb Akr1d1 Hexa Cyp4f39 Cyp39a1 Pomc Pld2 Vdr Pld6 Cyp2d5 Tecrl Synj1 Scap Fdx1 Plekha4 Plekha3 Plekha5 Pon3 Cubn Pon1 Pon2 Plekha8 Degs2 Synj2 Plekha1 Hsd3b1 Alppl2 Hsd3b2 Pik3cd Pik3cg Hsd3b7 Acadvl Acsl3 Acsl1 Hpgd Acsl6 Acsl5 Acsl4 Agpat1 LOC100361547 Gpx4 Agpat4 Cyp3a23/3a1 Agpat3 Ch25h Cyp3a73 RGD1564347 Pnpla8 Agpat9 Acaa2 Cyp2u1 Agpat6 Agpat5 Etnk1 Fabp2 Cyp2c7 Pnpla3 Alox15b Gpam Alox12 Mogat1 Pnpla2 Cyp2e1 Glb1 Fabp9 Pnpla6 Ltc4s Samd8 Lpin2 Gstm4 Mogat2 Cyp2d4 Acbd7 Cyp3a18 Acad10 Lpin3 Acad11 Lpin1 Cyp1a1 LOC100910877 Ptgs1 RGD1562200 Cyp2d2 Acbd5 Dgat2 Gk2 Hacl1 Ptgs2 Acbd6 Ephx2 Plin3 Gpat2 Dhcr24 Cyp1a2 Mmaa Gpd2 Alox15 Cyp2d3 Acbd4 Pi4k2b Cyp2c6v1 Agmo Slco1a1 Ddhd2 Ddhd1 Arv1 Slc44a4 Phyh Slco1a4 Slco1a2 Slc44a5 Mboat1 RGD1306195 Slc44a3 Hmgcl Slco1b2 Mboat7 LOC688708 Akr1b7 Akr1b8 Kdsr Mtmr14 LOC102556347 Ppara Mtmr12 Taz Ppard Star Acadl Hmgcs2 Acads Cyp7b1 Acadm Sgpp2 Pip5k1c Hrasls5 Pi4k2a Pip5k1b Pip5k1a Hmgcs1 Akr1c2 Scd4 Hao2 Akr1c3 Cyp7a1 Tm7sf2 Cyp21a1 Fdxr Pcyt1b Pcyt1a Tgs1 LOC100911186 Them5 Acsf2 Cyp2r1 Scd1 Scd2 Acsf3 Pitpnm1 Dbi Pitpnm3 Pitpnm2 Morc2 Ocrl Akr1c1 LOC100911941 Stard10 Osbp Fads1 Pcyt2 Mtmr9 Mtmr6 Mtmr7 Mtmr2 Ggps1 Dpep2 Ptges Tbl1xr1 Faah Pla2g2a Pla2g2f Pla2g2d Gpd1l Pla2g1b LOC686302 Elovl1 LOC100911615 Elovl5 Slc25a1 Elovl2 Elovl3 Crot Slc27a5 Chka Mtmr3 Mfsd2a Mtmr1 Elovl6 Cyp11b2 Sgms1 Cyp27b1 Morc2b Decr1 Slco1a6 Pik3c3 Hacd1 Ncoa2 Phospho1 Dhcr7 Glb1l Bdh2 Hadh Akr1b1 Sphk2 Arsb Lpgat1 Pik3r4 Hadha Col4a3bp Hadhb Cyp8b1 Gpd1 Hsd17b14 Slc10a1 Hmgcr Ebp Pemt Crat Pccb Hacd4 Hacd3 Pikfyve Hsd11b2 Hsd17b13 Slc10a2 Hsd17b12 Hsd17b11 Psap Acly Cpne3 Fabp5 Aldh3b1 Cpne1 RGD1564463 Ptges2 Alox5 Neu1 Lta4h Arsi Smpd1 Arse Cptp Arsg Smpd2 Esyt3 Smpd3 Arsk Sts Esyt2 Slc27a2 Smpd4 Dgat1 Gba2 Sumf2 Sumf1 B3galnt1 Ugt8 Ugcg Gm2a Kpnb1 Pld1 Med1 Fabp3 Fabp6 Fabp1 LOC100910990 Fabp4 Gk Fabp12 Pnpla5 Fabp7 Mgll Arsa Acaa1a Acaa1b Carm1 Slc44a2 Ptges3 Ptges3l1 Them4 Crebbp Rbm12 Ncoa1 Asah1 Pik3r1 Pik3r2 Sptlc3 Sptlc1 Prkd3 Sptlc2 Prkd1 Prkd2 Oxct1 Csnk2b Gla Pik3cb Agpat2 Degs1 INWARDLY RECTIFYING K+ CHANNELS%REACTOME DATABASE ID RELEASE 66%10145793 Inwardly rectifying K+ channels Kcnj4 Kcnj6 Gnb3 Kcnj16 Gnb2 Gnb1 Gng12 Kcnj2 Kcnj3 Kcnj11 Kcnj14 Kcnj15 Kcnj9 Abcc8 Gng4 Kcnj5 Gngt2 Kcnj8 Gabbr1 Gng5 Kcnj12 Gngt1 Gng8 Gabbr2 Gng10 Abcc9 Gng3 TFAP2 (AP-2) FAMILY REGULATES TRANSCRIPTION OF GROWTH FACTORS AND THEIR RECEPTORS%REACTOME%R-RNO-8866910.1 TFAP2 (AP-2) family regulates transcription of growth factors and their receptors Atad2 Lhb Esr1 Cga SIGNALING BY ROBO RECEPTORS%REACTOME%R-RNO-376176.1 Signaling by ROBO receptors Evl LOC100909750 Cxcl12 Rhoa Pfn1 Robo2 Pfn2 Robo3 Prkca Akap5 Enah Myo9b LOC100909840 Vasp Dag1 Abl2 Gpc1 Robo1 Cxcr4 Usp33 Slit3 Abl1 Slit2 ORGANIC ANION TRANSPORTERS%REACTOME DATABASE ID RELEASE 66%10145484 Organic anion transporters Slc5a5 Slc5a8 Slc25a22 Slc17a5 Slc17a6 Slc17a7 Slc17a8 Slc25a10 LOC100911440 Slc25a18 AXONAL GROWTH INHIBITION (RHOA ACTIVATION)%REACTOME%R-RNO-193634.1 Axonal growth inhibition (RHOA activation) Rhoa Arhgdia Rtn4 Lingo1 Ngfr Omg Mag DOWNREGULATION OF ERBB2 SIGNALING%REACTOME%R-RNO-8863795.1 Downregulation of ERBB2 signaling Ptpn18 Ereg Rnf41 Nrg1 Btc LOC102552659 Erbb3 Erbb2 Nrg3 Matk Egfr LOC103692716 Hbegf Akt1 Nrg4 Akt3 Erbb4 Ptpn12 Usp8 Akt2 Nrg2 Stub1 ROS, RNS PRODUCTION IN PHAGOCYTES%REACTOME DATABASE ID RELEASE 66%10145602 ROS, RNS production in phagocytes Atp6v1d Slc11a1 Tcirg1 Atp6v0d1 Atp6v1c2 Nos3 Atp6v0d2 Atp6v1a Atp6v0e2 Atp6v0e1 Atp6v1g3 Atp6v1e1 Atp6v1e2 Atp6v1c1 Nos1 Atp6v1g1 Atp6v1g2 Atp6v0a4 Atp6v0a1 Atp6v1b2 Atp6v0a2 Atp6v1h Atp6v1f LOC497963 Ncf1 Ncf4 Cybb Cyba Atp6v0c GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME%R-RNO-354194.1 GRB2:SOS provides linkage to MAPK signaling for Integrins Fn1 Src Tln1 Vwf Rap1a Apbb1ip Fgb Fgg Fga Itga2b Ptk2 Sos1 Grb2 AMPLIFICATION OF SIGNAL FROM UNATTACHED KINETOCHORES VIA A MAD2 INHIBITORY SIGNAL%REACTOME DATABASE ID RELEASE 66%10145062 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Cenpn Zwilch Cenpl Nup43 Cenpo Nup98 Nup133 Dync1li2 Nup107 Cenpt Cenpu Bub3 Bub1 Spdl1 Kntc1 Dync1i2 Mad1l1 Cenpk Cenph Nup37 Cenpi Cenpf Cenpe Cenpm Ahctf1 Ndel1 Cdca8 Dync1h1 Rcc2 Pafah1b1 Dync1li1 Rangap1 Mis12 Ppp1cc LOC100909468 Aurkb Dynll2 Ndc80 Sec13 Cenpc Xpo1 Cenpa Dync1i1 LOC100911204 Ranbp2 Spc24 Spc25 Birc5 Taok1 Itgb3bp Sgol2 Ppp2r5e Incenp Nsl1 B9d2 Cdc20 Kif2a Kif2c Kif2b Bub1b Kif18a Ppp2r5c Ppp2cb Ppp2r5a Ppp2ca Ppp2r1a Ppp2r5b Zwint Dsn1 Mad2l1 Nup85 Casc5 Clasp2 Ercc6l Nuf2 Clasp1 LOC679582 Ppp2r1b Mapre1 Pmf1 Ckap5 Ska2 Sgol1 Zw10 Ska1 GDP-FUCOSE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 66%10145727 GDP-fucose biosynthesis Fuom Slc35c1 Fuk Tsta3 Gmds LOC100911225 Fpgt REGULATION OF SIGNALING BY CBL%REACTOME%R-RNO-912631.1 Regulation of signaling by CBL Fyn Pik3r3 Pik3r1 Crk Pik3r2 Cbl Pik3cb Lyn Crkl Yes1 Vav1 Pik3cd Hck Rapgef1 Syk LOC100911248 Grb2 CALNEXIN CALRETICULIN CYCLE%REACTOME DATABASE ID RELEASE 66%10145711 Calnexin calreticulin cycle Edem3 Calr Man1b1 Rnf139 Ganab Edem2 Uggt1 Trim13 Rnf5 Prkcsh Canx Rnf103 March6 Os9 Sel1l COLLAGEN CHAIN TRIMERIZATION%REACTOME DATABASE ID RELEASE 66%10145922 Collagen chain trimerization Col20a1 Col19a1 Col13a1 LOC100910384 Col8a1 Col8a2 Col3a1 Col28a1 Col1a1 Col22a1 Col1a2 Col16a1 Col18a1 Col5a2 Col5a1 Col9a1 Col27a1 Col9a2 Col11a2 Col9a3 Col11a1 Col5a3 Col26a1 Col14a1 Col7a1 Col23a1 Col17a1 SHC-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%R-RNO-2428933.1 SHC-related events triggered by IGF1R Igf2 Igf1 Sos1 Shc1 Grb2 RAS ACTIVATION UPON CA2+ INFLUX THROUGH NMDA RECEPTOR%REACTOME%R-RNO-442982.1 Ras activation upon Ca2+ influx through NMDA receptor Grin2d Camk2g Grin2b Grin1 Nefl Rasgrf1 Dlg1 Dlg2 Dlg3 Camk2d Actn2 Camk2a Lrrc7 Hras Dlg4 FRS-MEDIATED FGFR1 SIGNALING%REACTOME DATABASE ID RELEASE 66%10146102 FRS-mediated FGFR1 signaling Kras Frs3 Fgf23 Fgf22 Fgf4 Fgf1 Fgf3 Fgf6 Fgf5 Fgf20 Fgf16 Fgf17 Fgf10 Fgf9 Fgfr2 Fgf7 Fgf2 Fgf8 Fgfr3 Fgfr1 Fgfr4 Ptpn11 Fgf19 Hras Nras Sos1 Frs2 Grb2 MASTL FACILITATES MITOTIC PROGRESSION%REACTOME%R-RNO-2465910.1 MASTL Facilitates Mitotic Progression Ensa Arpp19 SYNTHESIS OF PE%REACTOME%R-RNO-1483213.1 Synthesis of PE Etnppl Pcyt2 Lpin2 Cept1 Lpin3 Phospho1 Lpin1 Chka Etnk1 INOSITOL TRANSPORTERS%REACTOME DATABASE ID RELEASE 66%10145635 Inositol transporters Slc5a11 Slc2a13 PHOSPHOLIPID METABOLISM%REACTOME%R-RNO-1483257.1 Phospholipid metabolism Enpp6 Pten Pla2g6 Pla2g3 Pla2g5 Pitpnb Sbf1 Ptpn13 Pla2g16 Pla2g15 Pla2g10 LOC103689982 Csnk2a2 Cpne3 Osbpl5 Osbpl8 Pla2g12a Csnk2a1 Fam73b Stard7 Sacm1l Awat2 Lpcat4 Alpp Alpi Lpcat1 Plbd1 Abhd4 Fig4 Lipi Cpne6 Acp6 Lpcat3 Cpne7 Cpne1 Lpcat2 Gnpat Agk Vac14 Abhd3 Tmem86b Lclat1 Tmem55b Pip4k2b Bche Pip4k2c Pla2g4cl1 Chat Pik3r5 Bmx Ache Etnppl Cept1 Pik3r3 Pld2 Pik3r6 Pld6 Synj1 Pi4kb Mtmr4 Plekha4 Plekha3 Plekha5 Inpp5d Inpp5e Plekha8 Synj2 Plekha1 Inpp5f Alppl2 Tnfaip8l3 Dgat2l6 Pik3cd Tnfaip8l1 Pik3cg Inpp5j Tnfaip8 Tnfaip8l2 Rufy1 Agpat1 Agpat4 Ptdss2 Agpat3 Cdipt Pnpla8 Agpat9 Dgat1 Agpat6 Agpat5 LOC317456 Etnk1 Pnpla3 Osbpl10 Gpam Pnpla2 Pnpla6 Crls1 Lpin2 Lpin3 Lpin1 Dgat2 Gpat2 Pik3c2a Gpd2 Pik3c2b Pi4k2b Pik3c2g Cds2 Ddhd2 Ddhd1 Pla2r1 Slc44a4 Pld1 Tpte2 Pla2g4e Slc44a5 Pla2g4b Mboat1 Pla2g4d Slc44a3 Inpp4a Mboat7 Inpp4b Pctp Pla2g4a LOC100910990 Cds1 Mtmr14 Mtmr12 Pla2g4c Taz Mgll Pip5k1c Hrasls5 Pi4k2a Pip5k1b Pip5k1a Slc44a2 Pcyt1b Pcyt1a Pitpnm1 Pitpnm3 Pitpnm2 Rbm12 Ocrl Stard10 Pcyt2 Mtmr9 Mtmr6 Mtmr7 Pik3r1 Pik3r2 Mtmr2 Pla2g2a Pla2g2f Pla2g2d Gpd1l Pla2g1b LOC686302 LOC100911615 Chka Mtmr3 Mfsd2a Mtmr1 Csnk2b Pik3c3 Phospho1 Lpgat1 Hadha Pik3r4 Hadhb Gpd1 Pik3cb Agpat2 Pemt Pikfyve BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN%REACTOME%R-RNO-446193.1 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein Ctsa Mvd Fuom Slc35c1 Fuk Tsta3 Gmds LOC100911225 Fpgt St8sia1 Alg1 Gfpt2 Nus1 Alg2 Neu4 Dolpp1 Neu2 Gfpt1 St8sia3 Alg6 Alg3 Alg9 Neu3 Alg8 Neu1 Renbp St3gal5 Mpi Pgm3 Pmm2 Alg14 Pmm1 Srd5a3 Alg12 Nans Slc35a1 St8sia5 Slc17a5 St6galnac1 St6galnac2 Nudt14 Npl LOC501189 Dhdds St8sia4 Cmas LOC100910177 Nanp Dolk St6gal1 Glb1 St6gal2 Amdhd2 St6galnac4 St3gal2 St6galnac3 St3gal3 Nagk Gne Mpdu1 St3gal1 Dpagt1 St6galnac6 Gnpnat1 Dpm3 Dpm2 St3gal4 Dpm1 St3gal6 Uap1 BBSOME-MEDIATED CARGO-TARGETING TO CILIUM%REACTOME DATABASE ID RELEASE 66%10146078 BBSome-mediated cargo-targeting to cilium Ttc8 Bbs9 Bbs1 Bbs2 Smo Mchr1 Arl6 Rab3ip Lztfl1 Sstr3 Bbs7 Bbs5 Bbs4 ACYL CHAIN REMODELLING OF PE%REACTOME%R-RNO-1482839.1 Acyl chain remodelling of PE Pla2r1 Pla2g6 Pla2g3 Pla2g5 Pla2g4e Mboat1 Pla2g4b Pla2g4d Pla2g16 Pla2g2a Pla2g2f Pla2g10 Pla2g2d Pla2g1b LOC686302 Pla2g4a Pla2g12a Pla2g4c Hrasls5 Lpcat4 Plbd1 Abhd4 Pnpla8 Lpcat3 Pla2g4cl1 RESOLUTION OF ABASIC SITES (AP SITES)%REACTOME%R-RNO-73933.1 Resolution of Abasic Sites (AP sites) Rfc1 Rfc2 Pole2 Pole4 Rpa1 Rpa2 Lig1 Tdg Mpg Neil1 Ogg1 Xrcc1 Neil2 Mbd4 Parp2 Smug1 Rpa3 Parp1 Pnkp Lig3 LOC100911727 Pole Polb Pold2 Nthl1 Pcna Pold1 Mutyh Pold4 Fen1 Adprhl2 Ung Parg Rfc5 Apex1 Rfc4 Rfc3 ACTIVATION OF AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145580 Activation of AMPA receptors Gria3 Gria4 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS%REACTOME%R-RNO-2122948.1 Activated NOTCH1 Transmits Signal to the Nucleus Notch1 Dtx2 Dtx4 Dtx1 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX)%REACTOME DATABASE ID RELEASE 66%10145441 Synthesis of Leukotrienes (LT) and Eoxins (EX) Alox5ap Cyp4a2 Cyp4f39 Cyp4a1 Dpep2 Dpep3 Cyp4f6 Cyp4a8 Mapkapk2 Dpep1 LOC688708 Ltc4s LOC100912391 Alox5 Cyp4f17 Alox15 Lta4h Cyp4f18 METABOLISM OF VITAMIN K%REACTOME%R-RNO-6806664.1 Metabolism of vitamin K Ubiad1 OVARIAN TUMOR DOMAIN PROTEASES%REACTOME%R-RNO-5689896.1 Ovarian tumor domain proteases Ripk2 Pten Apc Otub1 Otud3 Otud7b Ube2d1 LOC100910954 Cdk1 Traf6 Traf3 Vcp Esr1 Nod1 Nod2 Rhoa Zranb1 Ripk1 Vcpip1 Tnip1 Tnip2 Otub2 Tnfaip3 TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G2 CELL CYCLE ARREST%REACTOME DATABASE ID RELEASE 66%10146160 TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest Gadd45a Bax Sfn Cdk1 Aurka Pcna EPHB-MEDIATED FORWARD SIGNALING%REACTOME DATABASE ID RELEASE 66%10146024 EPHB-mediated forward signaling Grin2b Arpc4 Grin1 Src Rock1 Arpc3 Itsn1 Potef Rac1 Kalrn LOC100361457 Rock2 Sdc2 Actr3 Actr2 Arpc1b Fyn Actb Tiam1 Kdr LOC103692716 Cdc42 Vegfa Rhoa Arpc5 Pak1 Wasl Lyn Hras Ptk2 Yes1 Actg1 Rasa1 Shb Arhgef28 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS%REACTOME DATABASE ID RELEASE 66%10145068 APC C-mediated degradation of cell cycle proteins Psmc6 Psmb10 Psmb8 Psmb9 Psmb4 Psmb11 Bub3 Psmb5 Psmf1 Psmb6 Psmd4 Psmb2 Cul1 Psmd5 Psmd8 Psmd9 Psmb3 Psma8 Psmd11 Psmd12 Ccna2 Anapc11 Ccna1 Anapc15 Aurka Psmd13 Psmd14 Anapc10 Fzr1 Fbxo5 Cdk2 Aurkb Psmc3 G6pc Ube2d1 Cdc20 Psmb7 Psmb1 Bub1b Skp1 Mad2l1 Anapc7 Cdc26 Cdc14a Cdc27 Cdc23 Psma5 Pttg1 Ube2c Skp2 Cdkn1a Cdkn1b Cdk1 Anapc16 Cdc16 Nek2l1 Btrc Anapc4 Anapc2 Psma2 Anapc1 Psmc5 Psmd2 Psma1 Psma4 Psmc1 Psma3 Psmc4 Psmc2 Psma6 Psme1 Nek2 Psmd1 Psme2 Psmd7 Psmd3 Psmd6 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT%REACTOME DATABASE ID RELEASE 66%10144783 The citric acid (TCA) cycle and respiratory electron transport Mt-nd4 Ndufab1 Atp5f1 Ndufa7l Mt-nd5 Etfa Mdh2 Etfb LOC683884 Idh3g Mt-nd6 Nubpl Mt-nd2 Glo1 Idh2 LOC100911483 Cs Ndufb10 Ndufb11 Ndufa12 Ndufa11 Mt-atp6 Ndufa13 Ndufa10 Sucla2 Slc16a3 Slc16a8 Slc16a1 Ndufc2 Bsg Ucp2 Ecsit Ucp3 LOC100909612 Slc25a14 Ucp1 Ndufaf7 Ndufa7 Ndufaf5 Rxra Ppard Ldha Ndufb6 Ndufb3 LOC100912599 Ndufb5 Vdac1 Ldhb LOC100361505 Me2 Hagh Fahd1 Me3 Ndufb9 Ndufb4 Ndufb8 Ndufb7 Sdhc Sdhd Ndufaf3 Sdha Me1 Atp5j2 Dlst Ndufaf1 Ndufa2 Ndufa5 Ndufaf4 Ndufa6 Mt-atp8 Sdhb RGD1306782 Ndufa1 Ndufs3 LOC500350 Ndufs1 Ogdh Ndufs4 Atp5g3 Ndufs5 Ndufs2 Ndufs8 Coq10a Ndufs6 Ndufs7 Pdpr Timmdc1 Pdhb Atp5g2 Pdk3 Pdk4 Pdk1 Pdk2 LOC100365902 LOC684509 Pdha2 Pdha1 Pdhx Pdha1l1 Acad9 Suclg2 Ndufb2 Ldhc Nnt LOC679739 LOC100911417 Idh3a Etfdh Gstz1 LOC679195 D2hgdh Pdp1 LOC100910710 Aco2 LOC680288 Adhfe1 Idh3B LOC688963 Dlat L2hgdh Atp5l Atp5o Atp5h Tmem126b Atp5i Atp5j LOC100363268 Ndufv3 LOC100361144 Ndufv1 Ndufv2 Atp5s Atp5e Atp5d Fh Atp5b Dld BIOTIN TRANSPORT AND METABOLISM%REACTOME DATABASE ID RELEASE 66%10145370 Biotin transport and metabolism Acacb Slc5a6 Mccc2 Pdzd11 Hlcs Pccb Mccc1 Pc SHC-MEDIATED CASCADE:FGFR1%REACTOME DATABASE ID RELEASE 66%10146109 SHC-mediated cascade:FGFR1 Kras Fgf17 Fgf10 Fgf9 Fgf2 Fgf8 Fgfr1 Fgf23 Fgf22 Fgf4 Fgf1 Fgf3 Fgf6 Fgf5 Hras Nras Sos1 Shc1 Fgf20 Grb2 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE%REACTOME%R-RNO-77075.1 RNA Pol II CTD phosphorylation and interaction with CE Gtf2h1 Gtf2h2 Mnat1 RGD1565904 Ercc3 Polr2g Polr2h Polr2e Polr2f Polr2j Polr2k Polr2d Supt5h LOC100911822 Polr2i Polr2b Polr2c Ercc2 Polr2a Rnmt Rngtt LOC100912534 Gtf2f1 Gtf2f2 Cdk7 Ccnh Gtf2h3 Gtf2h5 Gtf2h4 AMINO ACID CONJUGATION%REACTOME DATABASE ID RELEASE 66%10145091 Amino Acid conjugation Glyatl3 Acsm1 Glyat ALPHA-LINOLENIC ACID (ALA) METABOLISM%REACTOME%R-RNO-2046106.1 alpha-linolenic acid (ALA) metabolism Acsl1 Acaa1a Acot8 Fads1 Acaa1b Acox1 Elovl1 Elovl5 Hsd17b4 Elovl2 Elovl3 Abcd1 THE PHOTOTRANSDUCTION CASCADE%REACTOME DATABASE ID RELEASE 66%10144866 The phototransduction cascade Cnga1 Gucy2f Pde6b Rcvrn Gucy2d Pde6a Rgs9 RGD1560341 Gnb5 Gnb1 Guca1b Ppef1 Metap2 Metap1 Gnat1 Nmt1 Guca1a Cngb1 Rgs9bp Fnta Nmt2 Sag Grk4 Grk1 Gngt1 Fntb Pde6g MITOCHONDRIAL FATTY ACID BETA-OXIDATION%REACTOME%R-RNO-77289.1 Mitochondrial Fatty Acid Beta-Oxidation Ndufab1 LOC683884 Echs1 Mut Pctp Acot7 Acot9 Acadl Acot2 Acads Acot5 Acadm Acadvl Decr1 Eci1 Hadh Acaa2 Hadha Hadhb Mcat LOC100911186 Them5 Acsf2 Acot11 Acbd7 Acad10 Pccb Acad11 Mcee Them4 Dbi Acot13 Acbd6 Mmaa SULFUR AMINO ACID METABOLISM%REACTOME%R-RNO-1614635.1 Sulfur amino acid metabolism Mpst Txn2 Suox Cbs Sqrdl Mtrr Bhmt2 Ethe1 Enoph1 Mtap Mri1 Mtr Adi1 Cdo1 Cth Tstd1 Tst Mat1a Slc25a10 Ahcy NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 66%10145481 Norepinephrine Neurotransmitter Release Cycle Rab3a Rims1 Stx1a Cplx1 Syt1 Maoa Vamp2 Stxbp1 Ppfia1 Ppfia2 Ppfia3 Ppfia4 Slc22a1 Bzrap1 Slc22a2 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145954 Binding and Uptake of Ligands by Scavenger Receptors LOC685953 Cd36 Stab2 Sparc Scarb1 Apol2 Hsp90b1 Colec12 RGD1309808 Scgb3a2 Apoa1 Cd163 Hbb-b1 Apol11a Apol3 Hpx Msr1 LOC100910885 Apol9a Calr Marco Hba1 Ambp Lrp1 RGD1565355 LOC287167 Apob Apoe FCERI MEDIATED CA+2 MOBILIZATION%REACTOME%R-RNO-2871809.1 FCERI mediated Ca+2 mobilization Vav3 RGD1560225 Ppp3ca Nfatc2 Tec Txk Lat Plcg1 Lyn Ppp3r1 Vav2 Sos1 Vav1 Nfatc3 Lcp2 Shc1 Syk Itk Grb2 BIOSYNTHESIS OF ELECTROPHILIC Ω-3 PUFA OXO-DERIVATIVES%REACTOME DATABASE ID RELEASE 66%10146319 Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives Alox5 Ptgs2 PTEN REGULATION%REACTOME%R-RNO-6807070.1 PTEN Regulation Psmc6 Pten Psmb10 Usp7 Trim27 Psmb8 Psmb9 Psmb4 Psmb11 Psmb5 Psmf1 Psmb6 Psmd4 Psmb2 Psmd5 Psmd8 Csnk2a2 Psmd9 Psmb3 Psma8 Psmd11 Csnk2a1 Psmd12 Pml Psmd13 RragB Psmd14 Psmc3 Akt1 Hdac1 Xiap Tnks Phc1 Stub1 Phc2 Mtor Rheb Rptor Lamtor4 Lamtor5 Mlst8 Rraga Rragc Akt3 Rragd Slc38a9 Otud3 Lamtor3 Sall4 Scmh1 Cbx4 Cbx2 Cbx8 Lamtor2 Cbx6 Lamtor1 Bmi1 Hdac2 Rnf2 Mbd3 Usp13 Ring1 Hdac1l Chd3 Chd4 Phc3 Prex2 Mta3 Tnks2 Mta1 Mta2 Gatad2a LOC100910717 Maf1 Gatad2b Akt2 Eed G6pc Rbbp7 Mecom Frk Psmb7 Psmb1 Csnk2b Psma5 Psma2 Psmc5 Psma1 Psmd2 Psma4 Psmc1 Psma3 Psmc4 Psma6 Psmc2 Psme1 Ezh2 Psmd1 Psme2 Psmd7 Psmd3 Psmd6 TFAP2A ACTS AS A TRANSCRIPTIONAL REPRESSOR DURING RETINOIC ACID INDUCED CELL DIFFERENTIATION%REACTOME%R-RNO-8869496.1 TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation Tfap2a SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1)%REACTOME DATABASE ID RELEASE 66%10145538 Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Gnat3 Dpp4 Lep Grp Gpr119 Ffar4 Gnb3 Gcg Ffar1 Gng13 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE%REACTOME DATABASE ID RELEASE 66%10145130 Toll Like Receptor 4 (TLR4) Cascade Map2k7 Ripk2 Tbk1 Itgam Map2k6 Ager Dusp3 Irf3 Map2k4 Map3k8 Dusp4 Peli3 Nfkbib LOC100912399 Peli2 Map3k1 Traf6 Cul1 Vrk3 Rps6ka2 Itgb2 Rps6ka1 App Rps6ka3 Rps6ka5 Bpi Tirap LOC100912585 Tab1 Dusp7 Dusp6 Rela Atf1 Atf2 Map3k7 Peli1 Irak2 Tlr4 Ikbke Tank Traf3 Nfkbia LOC100910771 Ube2n Lbp Ptpn4 Jun Ppp2cb Ppp2ca Skp1 Ppp2r1a Ticam2 Nfkb2 Cd14 Nfkb1 Mapk9 Mapk8 Fos S100b Mapk7 Dhx9 Fbxw11 Chuk Ppp2r1b Ecsit Mapkapk3 Btrc Mapkapk2 Mapk1 Nkiras1 LOC100362142 Nod1 Ptpn11 Nod2 Nkiras2 Creb1 Tab2 Tab3 LOC100912618 Ube2v1 Ikbkb Mapk14 Myd88 Tnip2 Mapk11 Mapk10 ADENYLATE CYCLASE ACTIVATING PATHWAY%REACTOME DATABASE ID RELEASE 66%10145191 Adenylate cyclase activating pathway Adcy8 Adcy9 Adcy5 Adcy3 Adcy4 Adcy7 Adcy6 Gnal SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL%REACTOME DATABASE ID RELEASE 66%10145908 Synthesis of pyrophosphates in the cytosol Nudt11 LOC100912928 Nudt3 Ppip5k1 Ppip5k2 Nudt10 Ip6k1 Ippk Nudt4 Itpk1 NEGATIVE REGULATION OF ACTIVITY OF TFAP2 (AP-2) FAMILY TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 66%10146003 Negative regulation of activity of TFAP2 (AP-2) family transcription factors Sumo1 Tfap2b Ube2i Tfap2c Tfap2a Tfap2d Tfap2e VLDL CLEARANCE%REACTOME DATABASE ID RELEASE 66%10146224 VLDL clearance Apobr Apob Vldlr Apoc1 LOC100910181 Apoc4 RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF HSCS%REACTOME DATABASE ID RELEASE 66%10146239 RUNX1 regulates transcription of genes involved in differentiation of HSCs Psmc6 Psmb10 Psmb8 Psmb9 Psmb4 Psmb11 Psmb5 Psmf1 Psmb6 Psmd4 Mnat1 Psmb2 Psmd5 Psmd8 Psmd9 Psmb3 Gata2 LOC100911167 Psma8 Psmd11 Psmd12 Tal1 Ldb1 Psmd13 Psmd14 Tp73 Gata1 Lmo2 Lmo1 LOC100909750 Psmc3 Ccnh Cbfb Yap1 Gata3 Abl1 Runx1 Kmt2a G6pc Psmb7 Psmb1 Psma5 Cdk7 Psma2 Psmc5 Psmd2 Psma1 Psma4 Psmc1 Psma3 Psmc4 Psmc2 Psma6 Psme1 Psmd1 Psme2 Psmd7 Psmd3 Psmd6 BIOSYNTHESIS OF DPAN-6 SPMS%REACTOME DATABASE ID RELEASE 66%10146307 Biosynthesis of DPAn-6 SPMs Alox12 Alox15 GROWTH HORMONE RECEPTOR SIGNALING%REACTOME DATABASE ID RELEASE 66%10145708 Growth hormone receptor signaling Stat5a Prl Sh2b1 Lyn Ptpn1 Gh1 Ghr Mapk1 REUPTAKE OF GABA%REACTOME%R-RNO-888593.1 Reuptake of GABA Slc6a11 Slc6a13 Slc6a1 Slc6a12 THYROXINE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 66%10145424 Thyroxine biosynthesis Slc5a5 Tpo Iyd Duox2 Duox1 Tshb Cga PLATELET ADHESION TO EXPOSED COLLAGEN%REACTOME%R-RNO-75892.1 Platelet Adhesion to exposed collagen Gp1ba Gp9 Fyn Gp5 Gp1bb LOC100911551 Lyn Vwf Fcer1g INITIAL TRIGGERING OF COMPLEMENT%REACTOME%R-RNO-166663.1 Initial triggering of complement C1s C1r Masp2 C1qb Colec10 Cfd C4a Colec11 C1qa C4b C3 LOC100909666 Gzmm LOC102549354 C2 FORMATION OF THE CORNIFIED ENVELOPE%REACTOME%R-RNO-6809371.1 Formation of the cornified envelope Tgm1 LOC100910942 Dsg4 Klk8 Dsg3 Dsg2 Dsc3 Ivl Spink5 Dsc2 Spink6 LOC684499 LOC100910851 Jup Rptn LOC100911681 Lipk Lipm LOC100360690 LOC689230 Stfa2l1 Stfa2l3 Stfa2l2 Dsp Dsg1 RGD1565682 Pkp1 Pkp4 Pkp3 Sprr3 Klk12 Klk13 Klk14 Stfa3l1 Casp14 Stfa3 Evpl Csta LOC100911797 Ppl Perp Cela2a LOC100362978 SIGNALING BY MET%REACTOME%R-RNO-6806834.1 Signaling by MET Ptpn1 Stat3 Rac1 Lamc1 Lamc2 Gab1 Cbl Arf6 Spint1 Gga3 Hgf Ptpn2 Stam2 Sh3gl2 Sh3gl1 Spint2 Sh3kbp1 Lamb1 Muc20 Hgfac Ptk2 Sh3gl3 Ranbp10 Lamb2 Tns4 Lamb3 Lrig1 Usp8 Stam Rab4a Kras Src Pik3r1 Ptprj Dock7 Ranbp9 Rab4b Crk Rap1a Itga3 Lama4 Ptpn11 Crkl Hras Nras Sos1 Lama1 Rapgef1 Shc1 LOC100911248 Grb2 RHO GTPASES ACTIVATE FORMINS%REACTOME%R-RNO-5663220.1 RHO GTPases Activate Formins Cenpn Zwilch Cenpl Nup43 Cenpo Nup133 Dync1li2 Cenpt Cenpu Bub3 Bub1 Potef Rac1 Spdl1 Kntc1 Dync1i2 Mad1l1 Cenpk Cenph Cenpi Nup37 Cenpf Cenpe Cenpm Ahctf1 Ndel1 Rcc2 Actb Pafah1b1 LOC100361515 Mis12 Dynll2 Diaph1 Ndc80 Cenpc Cenpa Dync1i1 Daam1 Srgap2 LOC100909840 Ranbp2 Actg1 Birc5 Taok1 Src Ppp2cb Ppp2ca Ppp2r1a Nup85 Ppp2r1b Rhob Rhoc Nup98 Nup107 Dync1h1 Cdca8 Evl Dync1li1 Rangap1 Fmnl1 Ppp1cc LOC100909468 Aurkb Sec13 Xpo1 LOC100911204 Spc24 Spc25 Itgb3bp Sgol2 Rhod Ppp2r5e Incenp Nsl1 B9d2 Cdc20 Kif2a Kif2c Kif2b Bub1b Kif18a Ppp2r5c Ppp2r5a LOC100361457 Ppp2r5b Zwint Dsn1 Mad2l1 Casc5 Clasp2 Ercc6l Nuf2 Clasp1 LOC679582 Dvl1 Mkl1 Mapre1 Cdc42 Pmf1 Dvl2 Dvl3 Rhoa Pfn1 Pfn2 Ckap5 Scai Ska2 Sgol1 Zw10 Srf Ska1 CITRIC ACID CYCLE (TCA CYCLE)%REACTOME%R-RNO-71403.1 Citric acid cycle (TCA cycle) Idh3a Ogdh Mdh2 Idh3g Me2 Aco2 Fahd1 Idh2 Me3 Idh3B Cs Sdhc Sdhd Sdha Dlst Sucla2 Suclg2 Fh Sdhb Nnt Dld CHAPERONIN-MEDIATED PROTEIN FOLDING%REACTOME%R-RNO-390466.1 Chaperonin-mediated protein folding Cct6b Gnai3 Rgs9 Csnk2a2 Gnat3 Gnao1 Cct6a Csnk2a1 Tcp1 Cct7 Rgs7 Cct4 Gnat2 Pdcl Gnaz Cct3 Csnk2b Gnai2 Gnb3 Gnb5 Cct2 Gnb2 Gnb1 Gng13 Gng12 Gng11 Gnat1 Cct8 LOC100912034 Gnb4 Gng4 Gngt2 Gnai1 Gng5 Gngt1 Gng10 Gng8 Gng3 KINESINS%REACTOME%R-RNO-983189.1 Kinesins Kif21a Kif21b Kifc1 Kif3c Racgap1 Klc1 Kif22 Kif3b Kif23 Kif18b Kifap3 Kif11 Kif12 Kif4a Kif2a Kif6 Kif2c Kif1a Kif2b Kif1c Kif18a Kif27 Klc4 Kif9 Kif5b Kif13b Cenpe Kif5a Klc2 Klc3 Kif3a Kif20b Kif16b Kif26a Kif20a Kif26b Kif19 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL%REACTOME DATABASE ID RELEASE 66%10145904 Synthesis of IP3 and IP4 in the cytosol Plcd3 Plcb1 Plcz1 Plcd1 Pten Plcd4 Inpp5b Itpka Plce1 Pld4 Plcb3 Synj1 Plch1 Plch2 Plcb4 Inpp5d Plcg1 Itpkb Itpkc Itpk1 Ocrl Inpp5j CARGO RECOGNITION FOR CLATHRIN-MEDIATED ENDOCYTOSIS%REACTOME%R-RNO-8856825.1 Cargo recognition for clathrin-mediated endocytosis Agtr1b Agtr1a Syt11 Aak1 Sgip1 Eps15l1 LOC100909548 Itsn2 Scarb2 Igf2r Necap1 Egfr Agfg1 Snap91 Ubqln2 Picalm Tgoln2 Ldlr Tor1a Ston2 Syt1 Tfrc Vamp2 RGD1307443 Tf Chrm2 Necap2 Cd4 Tor1b Avp Dab2 Ston1 Ap2a2 Cops8 Cops2 LOC100361515 Cbl Vamp8 Stam2 Apob Sh3gl2 Sh3gl1 Sh3kbp1 Sh3gl3 Stam Nedd8 Itsn1 Wnt5a Cltc Cltb Clta Fzd4 Ap2s1 Cops4 Cops6 Ap2a1 Ap2m1 Cops3 Cops7b Cops7a Arrb1 Cd3g Slc2a8 Dvl2 Syt8 Arrb2 Cd3d Syt9 Syt2 Fcho2 Fcho1 M6pr Ldlrap1 Adrbk1 Vamp4 Vamp3 Adrb2 Vamp7 Grb2 Tacr1 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR%REACTOME DATABASE ID RELEASE 66%10145698 Activation of Ca-permeable Kainate Receptor Grik1 Dlg1 Grik3 Grik2 Ncald Grik5 Dlg3 Dlg4 SIGNALING BY RHO GTPASES%REACTOME DATABASE ID RELEASE 66%10144889 Signaling by Rho GTPases Cenpn Zwilch Cenpl Cenpo Klc1 Racgap1 Dync1li2 Cenpt Cenpu Abi1 Bub3 Bub1 Abi2 Potef Spdl1 Kntc1 Dync1i2 Mad1l1 Rtkn Myh9 Nck1 Cenpk Cenph Cenpi Rock2 Klc4 Cenpf Kdm1a Cenpe Cenpm Klc2 Ahctf1 Klc3 Ndel1 Rcc2 Noxo1 Arpc1b LOC100909750 Actb Inpp5b Pafah1b1 Rhpn1 Ncf1 Ncf4 Rhpn2 Ppp1r12a LOC100361515 Mis12 Dynll2 Ndc80 Cenpc Noxa1 Ppp1r14a Cenpa Dync1i1 Daam1 Srgap2 LOC100909840 Ptk2 Actg1 Cyfip2 Birc5 Nckap1 Taok1 Nup85 Cdh1 A2m Rhob Dlg4 Rhoc Nup98 Myh14 Myh11 Nup107 Prc1 Cit Cdca8 Flna Pkn1 Evl Cyfip1 Tax1bp3 Pkn2 Pkn3 Brk1 Cdc25c Rangap1 Fmnl1 Ppp1cb Baiap2 Ppp1cc LOC100909468 Aurkb Limk1 Gdi2 Sec13 Nf2 Xpo1 Pak2 Pak3 Pak1 Rac2 Wasl Nckap1l LOC100911204 Spc24 Spc25 Nox3 Nox1 Ocrl Abl1 Itgb3bp Arhgef6 Sgol2 Arhgef5 Rhod Arhgef39 Wasf1 Arhgef7 Arpc4 Rock1 Arhgef37 Ppp2r5e Arhgef38 Incenp Rhoq Arhgef33 Ktn1 Prex1 Arpc3 Nsl1 LOC102551071 Itsn1 B9d2 Arhgef2 Cdc20 Kif2a LOC102556447 Arhgef4 Kif2c Arhgef3 Kif2b Plekhg5 Men1 Arhgef19 Bub1b Arhgef18 Kif18a Plekhg2 Ppp2r5c Kalrn Ppp2r5a Nckipsd LOC100361457 LOC100912512 Ppp2r5b LOC687609 Zwint Dsn1 Vav2 Mylk Kif5b Gna13 Mad2l1 Vav1 Kif5a Arhgef11 Casc5 Akap13 Actr3 Arhgef16 Lin7b Arhgef15 Was Net1 Clasp2 Ect2 Ercc6l Arhgef26 Ctnna1 Fgd2 Mcf2l Nuf2 Tiam1 Pik3c3 Ncoa2 Tiam2 Clasp1 Vav3 LOC679582 Iqgap3 Dvl1 Mkl1 Fgd3 Pik3r4 Sos2 Pdpk1 Ngef Mapre1 Cdc42 LOC100911597 Pmf1 Dvl2 Dvl3 Pfn1 Pfn2 Ckap5 Scai Ska2 Wipf1 Wipf2 Wipf3 Iqgap1 Sgol1 Zw10 Srf Ska1 Arhgap18 Arhgap19 Arhgap21 Nup43 Arhgap17 Nup133 Myo9a Arhgap22 Arhgap10 Arhgap20 Srgap1 Srgap3 Arhgap39 Rhobtb2 Arhgap36 Depdc1b Rac1 Arhgap44 Arhgap35 Arhgap5 Arhgap6 Arhgdib Rhoj Ralbp1 Rhoh Nup37 Depdc7 Arhgap11a Dlc1 Syde1 Syde2 Fam13a Fam13b Gmip Arhgap15 Arhgap12 Arap1 Stard13 Tagap Chn2 Stard8 Ophn1 Arhgap1 Arhgap8 Rhot2 Rhot1 Diaph1 Ranbp2 Src Ppp2cb Ppp2ca Ywhah Ywhag Sfn Ppp2r1a Ywhaz Ywhab Ywhaq Ywhae Ppp2r1b Mapk1 Arhgap26 Arhgap25 Arhgap29 Arhgap23 Arhgap28 Arhgap27 Arhgap42 Arhgap40 Arhgap32 Arhgap30 Arhgap31 Hist1h2bo Dync1h1 Hist1h2bcl1 Hist2h3c2 Hist1h2bk H3f3b Dync1li1 Cybb Cyba Hmha1 LOC100910200 H2afx Hist1h4b LOC684841 Hist1h2bh Pik3r2 LOC100912290 Hist1h2ail1 Hist1h4m LOC102549173 LOC103690002 LOC100910152 LOC100912338 Hist1h3c H2afb3 Hist1h3f Hist2h4 LOC684819 Hist1h3a Myo9b H2afj Hist2h2aa3 Hist1h2bq Hist2h2aa2 LOC100364835 LOC684762 Actr2 Arhgap9 Rhoa Arhgdia Arpc5 Hist1h2bg LOC680097 Rhof Sos1 LOC684797 Rhog LOC100912418 Hist1h2ba Hist3h2bb Grb2 OLIGOMERIZATION OF CONNEXINS INTO CONNEXONS%REACTOME DATABASE ID RELEASE 66%10145304 Oligomerization of connexins into connexons Gjb1 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKK%REACTOME%R-RNO-442717.1 CREB phosphorylation through the activation of CaMKK Camkk1 Camk4 PEPTIDE CHAIN ELONGATION%REACTOME%R-RNO-156902.1 Peptide chain elongation Eef2 CLASS B 2 (SECRETIN FAMILY RECEPTORS)%REACTOME%R-RNO-373080.1 Class B 2 (Secretin family receptors) Ghrh Ramp3 Vipr2 Sct Gip Gipr Pth1r Iapp Crhr2 Gcgr Adgre1 Crhr1 Glp2r Pth2 Ramp2 Ghrhr Gng10 Pth Sctr Adm Crhbp Calcb Vip Calca Ramp1 Adcyap1r1 Ucn Adcyap1 Ucn2 Pth2r Adm2 Crh Gnb3 Gnb5 Gnb2 Gnb1 Gng13 Gng12 Gng11 LOC100912034 Gnb4 Glp1r Gcg Gng4 Gngt2 Gng5 Gngt1 Gng8 Gng3 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME DATABASE ID RELEASE 66%10145219 Activation of APC C and APC C:Cdc20 mediated degradation of mitotic proteins Psmc6 Psmb10 Psmb8 Psmb9 Psmb4 Psmb11 Bub3 Psmb5 Psmf1 Psmb6 Psmd4 Psmb2 Psmd5 Psmd8 Psmd9 Psmb3 Psma8 Psmd11 Psmd12 Anapc11 Ccna2 Ccna1 Anapc15 Psmd13 Anapc10 Psmd14 Psmc3 G6pc Ube2d1 Cdc20 Psmb7 Psmb1 Bub1b Mad2l1 Anapc7 Cdc26 Cdc27 Cdc23 Psma5 Pttg1 Ube2c Cdk1 Anapc16 Cdc16 Nek2l1 Anapc4 Psma2 Anapc2 Anapc1 Psmc5 Psmd2 Psma1 Psma4 Psmc1 Psma3 Psmc4 Psmc2 Psma6 Psme1 Nek2 Psmd1 Psme2 Psmd7 Psmd3 Psmd6 IRE1ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 66%10145532 IRE1alpha activates chaperones Sec63 Serp1 Sec61a1 Sec62 Sec61a2 Sec61b Asna1 LOC100363239 Sec61g Ern1 LOC100361694 RHESUS GLYCOPROTEINS MEDIATE AMMONIUM TRANSPORT.%REACTOME DATABASE ID RELEASE 66%10145662 Rhesus glycoproteins mediate ammonium transport. Rhag Rhcg RNA POLYMERASE I TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 66%10144885 RNA Polymerase I Transcription Termination Gtf2h1 Gtf2h2 Mnat1 RGD1565904 Ubtf Polr1b Taf1d Ercc3 Taf1c Polr2h Cd3eap Polr2e Znrd1 Polr2f Polr1c Polr2k Polr1a Ptrf Ercc2 Ttf1 LOC100912534 Cdk7 Twistnb Polr1e Ccnh Gtf2h3 Tbp Gtf2h5 Gtf2h4 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B%REACTOME%R-RNO-174048.1 APC C:Cdc20 mediated degradation of Cyclin B Anapc7 Cdc26 Cdc27 Cdc23 Ube2c Ube2d1 Cdk1 Anapc16 Cdc16 Cdc20 Anapc4 Anapc2 Anapc1 Anapc11 Anapc15 Anapc10 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME%REACTOME%R-RNO-975155.1 MyD88 dependent cascade initiated on endosome Map2k7 Ripk2 Map2k6 Ager Dusp3 Map2k4 Map3k8 Dusp4 Peli3 Nfkbib LOC100912399 Peli2 Map3k1 Traf6 Cul1 Vrk3 Rps6ka2 Rps6ka1 App Rps6ka3 Rps6ka5 Tlr9 LOC100912585 Tab1 Dusp7 Dusp6 Rela Atf1 Atf2 Map3k7 Peli1 Irak2 Nfkbia LOC100910771 Ube2n Jun Ppp2cb Ppp2ca Skp1 Ppp2r1a Nfkb2 Nfkb1 Mapk9 Tlr7 Mapk8 Tlr8 Fos S100b Irak4 Mapk7 Dhx9 Fbxw11 Chuk Ppp2r1b Ecsit Mapkapk3 Btrc Mapkapk2 Dhx36 Mapk1 Nkiras1 LOC100362142 Nod1 Nod2 Nkiras2 Creb1 Tab2 Tab3 LOC100912618 Ube2v1 Ikbkb Mapk14 Myd88 Tnip2 Mapk11 Mapk10 DSCAM INTERACTIONS%REACTOME%R-RNO-376172.1 DSCAM interactions Mapk8 Mapk13 Mapk12 Pak1 Dscaml1 Dscam Mapk14 Rac1 Mapk11 MISCELLANEOUS TRANSPORT AND BINDING EVENTS%REACTOME%R-RNO-5223345.1 Miscellaneous transport and binding events Nipal1 Tusc3 Mrs2 Nipal4 Pqlc2 Ankh Lrrc8e Lrrc8c Lrrc8b Lrrc8a Azgp1 Dmtn Magt1 Pip Add1 Nipa1 Add2 Ctns Nipa2 Add3 Nipal2 Nipal3 MITOCHONDRIAL TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 66%10145117 Mitochondrial transcription initiation Polrmt Tfam Tfb2m PINK PARKIN MEDIATED MITOPHAGY%REACTOME DATABASE ID RELEASE 66%10146045 Pink Parkin Mediated Mitophagy Vdac1 Mfn1 Mfn2 LOC100911485 Tomm6 Tomm70a Tomm7 Tomm40 Sqstm1 Atg12 Map1lc3a Pink1 Mterfd1 Tomm20 Tomm22 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R)%REACTOME%R-RNO-2404192.1 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) Cilp Pik3r1 Pik3r2 Fgf23 Fgf22 Fgf4 Fgf1 Fgf3 Tlr9 Fgf6 Fgf5 Fgf20 Gab1 Pde3b Igf2 Igf1 Fgf16 Pik3c3 Fgf17 Irs2 Fgf10 Fgf9 Fgfr2 Fgf7 Fgf2 Fgf8 Pik3r4 Fgfr3 Trib3 Pdpk1 Fgfr1 Fgfr4 Pik3cb Ptpn11 Fgf19 Them4 Irs1 Frs2 Sos1 Shc1 Akt2 Grb2 INTERCONVERSION OF POLYAMINES%REACTOME DATABASE ID RELEASE 66%10145061 Interconversion of polyamines Smox Sat1 RGD1564480 Paox NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%R-RNO-2122947.1 NOTCH1 Intracellular Domain Regulates Transcription Notch1 Maml1 Rbpj Crebbp Kat2a Snw1 Rbpjl2 ELECTRIC TRANSMISSION ACROSS GAP JUNCTIONS%REACTOME DATABASE ID RELEASE 66%10145507 Electric Transmission Across Gap Junctions Gja10 Panx1 Gjd2 Gjc1 THE NLRP3 INFLAMMASOME%REACTOME%R-RNO-844456.1 The NLRP3 inflammasome Panx1 Nlrp3 Hsp90ab1 Sugt1 Pycard Txn1 Txnip Mefv Pstpip1 P2rx7 FCGR ACTIVATION%REACTOME DATABASE ID RELEASE 66%10145910 FCGR activation Fcgr1a Cd247 Src Fgr Fyn Cd3g Fcgr2b Lyn LOC103693683 Yes1 Hck Fcgr2a Syk Fcgr3a SLIT2:ROBO1 INCREASES RHOA ACTIVITY%REACTOME DATABASE ID RELEASE 66%10146285 SLIT2:ROBO1 increases RHOA activity Rhoa Myo9b Robo1 Slit2 TICAM1-DEPENDENT ACTIVATION OF IRF3 IRF7%REACTOME DATABASE ID RELEASE 66%10145179 TICAM1-dependent activation of IRF3 IRF7 Irf3 COX REACTIONS%REACTOME DATABASE ID RELEASE 66%10145051 COX reactions Ptgs1 SIGNALING BY VEGF%REACTOME DATABASE ID RELEASE 66%10145273 Signaling by VEGF Abi1 Abi2 Rac1 Nos3 Nck1 Rock2 Rictor Cyfip1 Fyn Ncf1 Brk1 Ncf4 LOC103692716 Baiap2 Trib3 Cybb Cyba Pak2 Pak3 Pak1 Them4 Nckap1l Ptk2 Cyfip2 Nck2 Nckap1 Akt2 Prkcd Sh2d2a Hspb1 Wasf1 Flt4 Kras Src LOC100911280 Rock1 LOC100909609 Flt1 Ptk2b Pik3r1 Pxn Pik3r2 Figf Shc2 Vegfc Nrp1 Nrp2 Jup Akt1 Vegfb Axl Pgf Prkcb Vav2 Vav1 Prkcz Mtor Ctnna1 Mapk13 Mapk12 Kdr Dscam Vav3 Crk Bcar1 Mlst8 Mapkapk3 Pdpk1 Mapkap1 Mapkapk2 Cdc42 Prkaca Pik3cb Akt3 Vegfa Prkacb Rhoa Prkca Plcg1 Dock1 Hras Ctnnd1 Nras Cdh5 Mapk14 Elmo2 Rasa1 Shb Mapk11 REGULATION OF MECP2 EXPRESSION AND ACTIVITY%REACTOME%R-RNO-9022692.1 Regulation of MECP2 expression and activity Hdac1 Hipk2 Hdac2 Sin3a Hdac1l ACTIVATION OF TRKA RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145141 Activation of TRKA receptors Ntrk1 Ngf DOWNSTREAM SIGNALING OF ACTIVATED FGFR2%REACTOME DATABASE ID RELEASE 66%10145255 Downstream signaling of activated FGFR2 Kras Pik3r1 Frs3 Fgf23 Fgf22 Fgf4 Fgf1 Fgf3 Fgf6 Fgf5 Fgf20 Gab1 Fgf16 Fgf17 Fgf10 Fgf9 Fgfr2 Fgf7 Fgf2 Fgf8 Fgfr3 Fgfr1 Fgfr4 Ptpn11 Plcg1 Fgf19 Hras Nras Frs2 Sos1 Shc1 Grb2 VASOPRESSIN-LIKE RECEPTORS%REACTOME%R-RNO-388479.1 Vasopressin-like receptors Oxtr Oxt LOC100909648 Avpr1b Avpr1a Avp ANCHORING OF THE BASAL BODY TO THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 66%10146081 Anchoring of the basal body to the plasma membrane Dync1i2 Nphp1 Cep57 Cep97 Rab8a B9d1 Cep162 LOC691918 Haus3 Ninl Akap9 Nphp4 Ccp110 Tmem216 Dync1h1 Rpgrip1l Pafah1b1 LOC103692716 Rab3ip Mks1 Dctn1 C2cd3 Cntrl Dctn2 Cep76 Sept2 Pcm1 Cep78 LOC100912537 Ttbk2 Mark4 B9d2 LOC100911033 Cep164 Dctn3 Ofd1 Cep41 Sclt1 Tctn1 Sdccag8 Tubb5 Cep83 Prkar2b Cenpj Ywhag Cep89 Ppp2r1a Plk4 Ywhae Ahi1 LOC100912076 Tubg2 Haus2 Haus1 Haus5 Alms1 Haus4 Clasp1 Odf2 Tubb4a Cdk1 Iqcb1 Rab11a Nek2l1 Tmem67 Ssna1 Tubg1 Mapre1 Cep63 Prkaca Csnk1d Cep131 Tuba4a Cep250 Cep135 Csnk1e Ckap5 Cdk5rap2 Kif24 Pcnt Nek2 Cep72 Sfi1 Cep70 Actr1a LOC100911746 Nedd1 Fbf1 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION%REACTOME%R-RNO-2730905.1 Role of LAT2 NTAL LAB on calcium mobilization Pik3cb Pik3r1 Pik3r2 Lyn Sos1 Pdpk1 Shc1 Syk Grb2 Lat2 NEPHRIN FAMILY INTERACTIONS%REACTOME%R-RNO-373753.1 Nephrin family interactions Nck1 Fyn Kirrel Kirrel3 Kirrel2 Wasl Iqgap1 Nck2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX%REACTOME%R-RNO-937042.1 IRAK2 mediated activation of TAK1 complex LOC100910771 Tab2 Tab3 Tab1 Map3k7 Traf6 Irak2 PYRIMIDINE SALVAGE%REACTOME DATABASE ID RELEASE 66%10144845 Pyrimidine salvage Uckl1 Tk2 Cda Hdhd1 Uck2 Upp1 Upp2 Tk1 Uck1 Tymp Dck LOC100909857 TWIK-RELATED ALKALINE PH ACTIVATED K+ CHANNEL (TALK)%REACTOME DATABASE ID RELEASE 66%10145847 TWIK-related alkaline pH activated K+ channel (TALK) Kcnk16 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS)%REACTOME%R-RNO-456926.1 Thrombin signalling through proteinase activated receptors (PARs) Src Gnaq Gna11 Gna14 Gna15 Gna12 Gna13 Gnb3 Gnb5 Gnb2 Gnb1 Gng13 Gng12 Gng11 Mapk1 Arrb1 Arrb2 LOC100912034 Gnb4 F2rl3 F2r F2 Gng4 Gngt2 Gng5 Gngt1 Gng10 Gng8 F2rl2 Gng3 DEADENYLATION OF MRNA%REACTOME DATABASE ID RELEASE 66%10145638 Deadenylation of mRNA LOC100912571 Cnot6l Pabpc2 Cnot11 Pabpc6 Eif4a3 Tnks1bp1 Cnot8 Rqcd1 Pan2 Cnot3 Cnot1 Zcchc6 Cnot2 LOC100911431 Eif4a2 Pabpc1 Cnot7 Cnot4 Eif4a1 Eif4g1 LOC680559 Eif4b FORMYL PEPTIDE RECEPTORS BIND FORMYL PEPTIDES AND MANY OTHER LIGANDS%REACTOME DATABASE ID RELEASE 66%10145663 Formyl peptide receptors bind formyl peptides and many other ligands Hebp1 Fpr-rs6 Fpr-rs3 Fpr1 Fpr2 Fpr3 Anxa1 Fpr-rs4 ACTIVATION AND OLIGOMERIZATION OF BAK PROTEIN%REACTOME DATABASE ID RELEASE 66%10145015 Activation and oligomerization of BAK protein Bak1 Bid A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS%REACTOME%R-RNO-1971475.1 A tetrasaccharide linker sequence is required for GAG synthesis Gpc6 Bcan Agrn Vcan Ncan Xylt2 Gpc4 Gpc2 Dcn LOC100910284 B3gat1 B3gat3 B3gat2 LOC102550316 B4galt7 Cspg5 Cspg4 Sdc2 Gpc1 Sdc3 Sdc4 B3galt6 PKA ACTIVATION IN GLUCAGON SIGNALLING%REACTOME%R-RNO-164378.1 PKA activation in glucagon signalling Prkaca Prkacb Prkar2b Prkar2a Prkar1b Prkar1a CLASS C 3 (METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS)%REACTOME DATABASE ID RELEASE 66%10145488 Class C 3 (Metabotropic glutamate pheromone receptors) Tas2r144 Grm3 Casr Grm1 Grm6 Tas2r113 Grm2 Grm8 Tas2r114 Tas2r110 Gprc6a Tas2r124 Tas2r125 Tas2r126 Tas2r121 Tas2r103 Tas2r104 Tas2r123 Tas2r116 Tas2r140 Tas2r120 Tas2r102 Tas2r145 Tas2r119 Tas2r118 Tas2r117 Tas2r107 Tas2r108 Tas2r105 Tas2r106 Tas2r129 Tas2r109 Tas2r136 Tas2r137 Tas1r1 Tas2r135 Tas2r13 Tas2r130 Tas1r3 Tas2r139 Gabbr1 Gabbr2 CA-DEPENDENT EVENTS%REACTOME DATABASE ID RELEASE 66%10144989 Ca-dependent events Prkcd Pde1b Adcy8 Adcy9 Adcy5 Adcy4 Adcy7 Adcy6 Prkar1b Prkar1a Mapk1 Prkaca Prkacb Pla2g4a Adcy3 Prkar2b Prkca Prkar2a Camk4 Adrbk1 SUMOYLATION OF RNA BINDING PROTEINS%REACTOME DATABASE ID RELEASE 66%10146034 SUMOylation of RNA binding proteins Nup93 Nup43 Nup98 Nup133 Nup107 Aaas Nup155 Nop58 Nup210 Npap60 Nup35 Nup88 Nup37 Nupl2 Nupl1 Nup85 Nup153 Sumo1 Tpr Rae1 Nup54 Pom121 Nup205 Ube2i Ranbp2 Nup62 VITAMIN B5 (PANTOTHENATE) METABOLISM%REACTOME%R-RNO-199220.1 Vitamin B5 (pantothenate) metabolism Slc5a6 Pdzd11 Ppcdc Pank4 Coasy Pank3 Pank2 Ppcs Pank1 LOC100362038 Aasdhppt Vnn1 Fasn ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING%REACTOME%R-RNO-451326.1 Activation of kainate receptors upon glutamate binding Plcb1 Dlg1 Plcb3 Dlg3 Grik1 Grik3 Gnb3 Gnb5 Grik2 Ncald Grik5 Gnb2 Gnb1 Gng13 Gng12 Gng11 LOC100912034 Gnb4 Gng4 Gngt2 Gng5 Gngt1 Gng10 Dlg4 Gng8 Gng3 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS%REACTOME DATABASE ID RELEASE 66%10145878 Transcriptional activation of mitochondrial biogenesis Sirt4 Sirt3 Gabpb1 Acss2 Sod2 Idh2 DOWNSTREAM SIGNALING OF ACTIVATED FGFR1%REACTOME%R-RNO-5654687.1 Downstream signaling of activated FGFR1 Kras Pik3r1 Frs3 Fgf23 Fgf22 Fgf4 Fgf1 Fgf3 Fgf6 Fgf5 Flrt1 Flrt2 Fgf20 Gab1 Fgf16 Fgf17 Fgf10 Fgf9 Fgfr2 Fgf7 Fgf2 Fgf8 Fgfr3 Fgfr1 Fgfr4 Ptpn11 Plcg1 Fgf19 Hras Nras Frs2 Sos1 Shc1 Grb2 TRP CHANNELS%REACTOME%R-RNO-3295583.1 TRP channels Trpc4ap Trpv4 Trpv5 Trpv6 Mcoln2 Mcoln3 Trpm2 Trpv1 Trpc5 Trpm6 Trpm3 Trpm8 Trpm5 Trpc3 Trpc7 Trpm1 Trpc4 Mcoln1 Trpc6 Trpv3 Trpa1 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION%REACTOME%R-RNO-2173796.1 SMAD2 SMAD3:SMAD4 heterotrimer regulates transcription Smad3 Ccnt2 Smad2 Sp1 E2f5 Rbl1 Cdk9 Snw1 E2f4 Men1 Atp1b4 Ccnk Wwtr1 Tfdp1 Tfdp2 DARPP-32 EVENTS%REACTOME DATABASE ID RELEASE 66%10145005 DARPP-32 events Prkar1b Ppp1ca Pde4a Prkar1a Ppp2r1b Pde4d Pde4c Ppp1r1b Cdk5 Prkaca Prkacb Ppp2cb Prkar2b Ppp2ca Prkar2a Ppp2r1a ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON%REACTOME DATABASE ID RELEASE 66%10145137 Activation of IRF3 IRF7 mediated by TBK1 IKK epsilon Cd14 Tbk1 Ptpn11 Irf3 Tlr4 Ticam2 Ikbke Tank Traf3 GLUCAGON-TYPE LIGAND RECEPTORS%REACTOME%R-RNO-420092.1 Glucagon-type ligand receptors Sctr Vip Adcyap1r1 Adcyap1 Ghrh Vipr2 Sct Gip Gipr Gnb3 Gcgr Gnb5 Gnb2 Glp2r Gnb1 Gng13 Gng12 Ghrhr Gng11 LOC100912034 Gnb4 Glp1r Gcg Gng4 Gngt2 Gng5 Gngt1 Gng10 Gng8 Gng3 SUMO E3 LIGASES SUMOYLATE TARGET PROTEINS%REACTOME DATABASE ID RELEASE 66%10145992 SUMO E3 ligases SUMOylate target proteins Nr1h4 Nup43 Nup133 Trim27 Mdm2 Vhl Pias3 Aaas Pias1 Npap60 Stag1 Nup35 Nup37 Pias4 Pml Rad21 Pias2 Smc1a Stag2 Smc3 Sumo1 Sumo3 Pcna Brca1 Blm Mdc1 Zfp131 Pcgf2 Xpc Ube2i Hdac4 Uhrf2 Ranbp2 Foxl2 Satb2 Satb1 Birc5 Topors Thra Thrb Nsmce1 Ing2 Nsmce2 Mbd1 Nr1h3 Nr1h2 Top1 Safb Park7 Smc6 Tp53bp1 Smc5 Nr5a1 Rora Nr1i2 Rad52 Mitf Herc2 Hdac1 Xrcc4 LOC100911274 Nup88 Rpa1 Hipk2 Nup85 Phc1 Phc2 Nfkb2 Tfap2c Sin3a Rae1 Nup93 Nup98 Nup107 Rxra Nup210 Ppara Nupl2 Rela Nupl1 Tdg Cdca8 Scmh1 Nr5a2 Cbx4 Cbx2 Cbx8 Bmi1 Hdac2 Rnf2 Rangap1 Ring1 Ikbke Hdac1l Phc3 Aurkb Esr1 Nfkbia Nup205 Ddx5 Mta1 Nrip1 Pgr Ncoa1 Hist1h4b Incenp Dnmt1 LOC100912290 Nup155 Nop58 Hist1h4m Dnmt3b Hist2h4 Nup153 Parp1 Tpr Daxx Mkl1 Nup54 Pom121 LOC680097 Nup62 LOC100912418 AXON GUIDANCE%REACTOME%R-RNO-422475.1 Axon guidance LOC102552659 Erbb2 Egfr Kif4a Potef Cdk5 Csnk2a2 Dnm2 Nck1 Csnk2a1 Rock2 Arpc1b LOC100909750 Fyn Actb Ephb1 Ephb2 Ephb4 LOC100909840 Ephb3 Ptk2 Efnb2 Actg1 Efnb1 Efnb3 Myl12a Nck2 LOC100909609 Nrp1 Ranbp9 Pik3cd Kdr Tln1 Vegfa Prkca Lyn Dock1 Yes1 Gpc1 Rasa1 Rhob Shb Arhgef28 Rhoc Grin2b Grin1 Mmp9 Mmp2 Rps6ka5 LOC100912585 Pip5k1c Evl Ptprc Col9a1 Col9a2 Col9a3 Sdcbp Prkcq Col4a1 Cd72 Siah1 Ret Siah2 Dpysl2 Limk1 Dpysl5 Dpysl4 LOC100910964 Col4a2 Pak2 Sh3gl2 Fes Pak3 Nrcam Pak1 Gdnf Sh3kbp1 Reln Rnd1 Wasl Plxnd1 Dag1 Ntn1 Pdlim7 Ntn4 Map2k2 Pspn Abl1 Dpysl3 Crmp1 Rras Ank1 Arhgef7 Plxna2 Arpc4 Plxna1 Rock1 Gap43 Sema7a Rdx Arpc3 LOC103692570 Rap1gap Sema6d Itsn1 Cdk5r1 Epha10 Dcc Farp2 Sema5a L1cam Ezr Trem2 Spta1 Kalrn Gfra4 Sema4d LOC100361457 Plxnb1 Gfra3 LOC100912512 Gfra2 Dok4 Vav2 Dok1 Dok6 Dok5 Arhgef11 Sema3a Sema3e Actr3 Efna2 Efna1 Artn Efna4 Shc3 Nrtn Mapk13 Ptpra Mapk12 Dnm1 Tiam1 Dscaml1 Dab1 Vav3 Dscam Dnm3 Epha4 Ncam1 Sptbn1 Epha5 Lypla2 Msn Epha7 Ngef Epha8 Cdc42 Epha3 Epha2 Epha1 Pfn1 Pfn2 Itga2b Aph1b Psenen Aph1a LOC100911293 Psen2 Psen1 Ncstn Rac1 Arhgap35 Sdc2 Ap2a2 Src Pik3r3 Hsp90ab1 Cltc Clta Ap2s1 Ap2a1 Ap2m1 Mapk8 Vldlr Mapk7 Mapk1 Prkaca Prkacb Creb1 Mapk14 Mapk11 Sptan1 Gab1 Irs2 LOC103692716 Fgfr1 Grb10 Frs2 Kras Grb7 Dok2 Pik3r1 Pik3r2 Cxcl12 Nfasc Robo2 Robo3 Akap5 Enah Tyrobp Myo9b Vasp Abl2 Robo1 Cxcr4 Usp33 Slit3 Slit2 Csnk2b Actr2 LOC501189 St8sia4 Pik3cb Ptpn11 Rhoa Arpc5 Plcg1 Hras Nras Sos1 Shc1 Grb2 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE%REACTOME%R-RNO-416572.1 Sema4D induced cell migration and growth-cone collapse Rock1 Rhoa LOC102552659 Sema4d Plxnb1 Rock2 Erbb2 Rnd1 Arhgef11 Rhob Rhoc FREE FATTY ACIDS REGULATE INSULIN SECRETION%REACTOME DATABASE ID RELEASE 66%10145587 Free fatty acids regulate insulin secretion Plcb1 Plcb3 Ffar1 Gnaq Gna11 Gna14 Gna15 SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN%REACTOME DATABASE ID RELEASE 66%10145615 Synthesis, secretion, and deacylation of Ghrelin Igf1 Ache Gh1 Pcsk1 Mboat4 Ghrl Lep Ins1 Ins2 Sec11c Gcg MGC109340 Pla2g7 Spcs2 Bche Sec11a SIGNALING BY NOTCH3%REACTOME DATABASE ID RELEASE 66%10145952 Signaling by NOTCH3 Aph1b Psenen Ybx1 Aph1a Dll4 Egfr Jag1 LOC100911293 Notch3 Psen2 Psen1 Ncstn OXYGEN-DEPENDENT ASPARAGINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA%REACTOME DATABASE ID RELEASE 66%10145810 Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha Hif1an Epas1 Hif1a REPRODUCTION%REACTOME%R-RNO-1474165.1 Reproduction Prdm9 Kcnu1 Cd9 Catsper3 Catsper2 Izumo3 Izumo1 Catsper4 LOC100911976 Spam1 Acr Izumo4 Izumo2 Hyal5 Hvcn1 PHOSPHOLIPASE C-MEDIATED CASCADE: FGFR1%REACTOME%R-RNO-5654219.1 Phospholipase C-mediated cascade: FGFR1 Fgf17 Fgf10 Fgf9 Fgf2 Fgf8 Fgfr1 Fgf23 Fgf22 Fgf4 Fgf1 Fgf3 Fgf6 Plcg1 Fgf5 Fgf20 MELANIN BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 66%10146119 Melanin biosynthesis Oca2 Slc45a2 Tyrp1 Tyr LOC308670 DIGESTION AND ABSORPTION%REACTOME%R-RNO-8963743.1 Digestion and absorption Pir Slc2a5 Amy2a3 Pnliprp1 Chia RGD1309110 Pnliprp2 Alpp Npc1l1 Alpi Pnlip Amy1a Chit1 Guca2b Guca2a Lct Si Slc5a1 Chi3l3 Gucy2c Alppl2 Slc2a2 Lipf Clps GAP JUNCTION DEGRADATION%REACTOME DATABASE ID RELEASE 66%10145296 Gap junction degradation Cltb Clta Gja1 Dnm2 Dnm1 Myo6 Dab2 Ap2m1 Cltc O-LINKED GLYCOSYLATION OF MUCINS%REACTOME%R-RNO-913709.1 O-linked glycosylation of mucins Galnt9 LOC102550196 Gcnt1 A4gnt Muc13 C1galt1 Muc15 C1galt1c1 B3gnt4 Galnt16 B3gnt7 Galnt18 Galnt14 B3gnt2 Galnt15 B3gnt3 Galnt12 Galnt13 B3gntl1 Galnt10 St6galnac2 B3gnt6 St6gal1 Galntl5 Galnt6 Galnt5 B4galt6 St6galnac4 St3gal2 B3gnt8 St3gal3 Muc1 St6galnac3 B4galt5 B3gnt5 Chst4 St3gal1 Muc20 Galnt1 Galnt7 St3gal4 Galnt3 Galnt2 CTLA4 INHIBITORY SIGNALING%REACTOME DATABASE ID RELEASE 66%10145541 CTLA4 inhibitory signaling Cd80 Src Cd86 Fyn Ppp2r5e Ppp2r1b Akt1 LOC100909468 Akt3 Ptpn11 Ppp2r5c Ppp2cb Ppp2r5a Ppp2ca Ppp2r5b Ppp2r1a Lyn Yes1 Akt2 PENTOSE PHOSPHATE PATHWAY%REACTOME%R-RNO-71336.1 Pentose phosphate pathway Dera Rpe Shpk Tkt Rbks Prps1l1 Taldo1 Rpia Pgls Pgm2 Prps2 UBIQUINOL BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 66%10145949 Ubiquinol biosynthesis Pdss2 Coq2 PHASE I - FUNCTIONALIZATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 66%10144820 Phase I - Functionalization of compounds Smox Nr1h4 Cyp1b1 RGD1564480 Svs1 Doxl2 Doxl1 Cyp19a1 Fdx1l Por LOC100360055 Aoc3 Ces2c Cyp46a1 Maoa Cyp4f17 Aldh2 Paox Cyp4f18 Cyp4f39 Tbxas1 Cyp39a1 Pomc Hsp90ab1 Cyp2d5 Cyp51 Fdx1 LOC100361547 Cyp3a23/3a1 Cyp3a73 Cyp4f6 Cyp2u1 Cyp2c7 Cyp2e1 LOC100912391 Cyp2d4 Cyp3a18 Cyp24a1 Cyp1a1 LOC100910877 Ptgs1 Cyp2d2 Cyp1a2 Cyp2d3 Cyp2c6v1 Cyp4a2 Cyp4a1 Ptgis Rxra Cyp4a8 Cyp2j10 Cyp7b1 Cyp7a1 Ptges3 Cyp21a1 Fdxr Ptges3l1 Cyp2r1 Ncoa1 Cyp2b2 Cyp2c24 Cyp2s1 Cyp2b1 Marc2 Marc1 Aip Acss2 Cyp2b3 Ephx1 Nqo2 Cyp26c1 Aldh3a1 LOC100910040 Bphl Ahrr LOC100361492 Ahr Cyp11b2 Maob LOC100910127 Cyp27b1 Ces1d Cyp2c13 LOC100910481 Aadac Ncoa2 Cmbl Ces2 Ces2j Cyp2b21 Arnt Ces2e Ces2g Acss1 Cbr3 Cyp8b1 Ces2h LOC100911763 Aoc1 Cyp2b15 Fmo1 Cyp2b12 Adh4 Fmo2 Cyp2f4 Cyp26a1 Adh6 Cyb5r3 Arnt2 Adh7 Cyb5b Cyp4v3 Aldh1b1 Cyp26b1 LOC100365112 PRESYNAPTIC PHASE OF HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME DATABASE ID RELEASE 66%10146131 Presynaptic phase of homologous DNA pairing and strand exchange Rhno1 Rfc2 Bard1 Wrn Topbp1 Rbbp8 Rmi1 Rmi2 Rad51c LOC100911267 Hus1 Rad51d Rad51 Brca2 Rad50 Rpa1 Rpa2 Atm Atrip Rpa3 Brca1 Rad1 Atr Blm Rad17 Slc25a16 Rfc5 Xrcc2 Rfc4 Rad9a Nbn Rfc3 Rad9b Mre11a SLC-MEDIATED TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 66%10144952 SLC-mediated transmembrane transport Slc7a3 Slc7a2 Slc7a1 Slco4a1 Slc4a7 Slc4a9 Slc2a9 Slc11a2 Slc7a8 Slc7a9 Sri Fgf21 Slc50a1 Slc7a5 Slc7a6 Slc7a7 Slc6a2 Heph Slc14a1 Slc18a1 Slc7a10 Slc30a10 Slc4a4 Slc4a3 Slc22a15 Slc6a7 Slc4a8 Slc6a9 Slc2a12 Slc2a10 Slc6a6 Slc6a5 Slc12a4 Slc39a2 Slc12a2 Slc39a3 Slc12a1 Slc39a4 Slc39a6 Slc8b1 Slc38a3 Slc38a2 Slc38a5 Slc38a4 Slc22a6 Slc8a3 Slc12a5 Slc22a3 Slc3a1 LOC100911874 RGD1559971 Slc25a29 Slc43a2 Slc43a1 Slc22a7 Vegp2 Slc39a7 Slc22a1 Slc39a8 Slc22a2 Slc12a6 Slc12a7 Slc47a1 Slc8a2 Slc6a3 Slc8a1 RGD1304770 Slc35c1 Slc5a6 Pdzd11 Slc1a3 Bsg Slc1a5 Slc1a4 Slc15a1 Slc1a7 Slc1a6 Lcn1 Slc1a1 Slc5a4 Slc5a1 Slc5a2 Slc9a1 Slc2a2 Slc24a4 Slc24a2 Slc20a2 Slc10a6 Ahcyl2 Slc35d1 Slco3a1 Slc45a3 Slc2a6 Slc2a4 Lcn12 Slc5a10 Slc4a2 Slc4a5 Slc4a1 Slc7a11 Slc13a4 Slc41a1 Slc41a2 Slc40a1 Slc24a5 Slc13a1 Slc26a2 Slc13a2 Slc26a1 Slc13a3 Slco1c1 Lcn9 Slc5a9 Slc5a7 Slc20a1 Slc4a10 Slc15a3 Slc27a1 Slco1a1 Slc35b2 Rhag Slc44a4 Slco1a4 Slc35b3 Slco1a2 Slc44a5 Slc44a3 Rhcg Slco1b2 Slc25a10 Slc5a11 Slc2a13 Slc30a5 Slc16a10 Slc30a6 Slc30a8 Slc27a6 Slc39a14 Slc9a4 Slc9a5 Slco2b1 Slc31a1 Slc26a7 Slc26a9 Slc26a6 Slc30a1 Slc27a4 Slc26a3 Slc36a2 Slc33a1 Slc34a1 Slc35a2 Slc16a2 Slc34a3 Slc32a1 Slc38a1 Slc6a15 Slc6a14 Slc6a19 Slc6a18 Ctns Slc35b4 Slc36a4 Slc6a20 Slc36a1 Slco1a6 Slco2a1 Slc35d2 Apod Slc2a1 Slc9a2 Slc9a9 RGD1561777 Slc9a3 Slc9a6 Cp Slc9a8 Slc9a7 Slc6a11 Slc6a13 Slc6a1 Slc6a12 Slc16a3 Slc16a7 Slc16a8 Slc16a1 Slc22a5 Slc28a2 Slc28a1 Slc28a3 Slc29a3 Slc29a2 Slc29a4 LOC100911721 Slc29a1 LOC691960 Slco4c1 Slc21a4 Slc11a1 Avp Slc44a2 Runx1 Slc35a1 Slc5a8 Slc25a22 Slc17a5 Slc17a6 Slc17a7 Slc17a8 LOC100911440 Slc25a18 Slc5a5 Slc2a8 ASYMMETRIC LOCALIZATION OF PCP PROTEINS%REACTOME%R-RNO-4608870.1 Asymmetric localization of PCP proteins Psmc6 Psmb10 Psmb8 Psmb9 Psmb4 Psmb11 Psmb5 Psmf1 Psmb6 Psmd4 Psmb2 Psmd5 Psmd8 Psmd9 Psmb3 Psma8 Psmd11 Psmd12 Psmd13 Psmd14 Smurf1 LOC100361515 Psmc3 Pard6a G6pc Wnt5a Prickle1 Fzd1 Psmb7 Fzd3 Psmb1 Fzd2 Fzd4 Fzd7 Psma5 Psma2 Psmc5 Psmd2 Psma1 Dvl2 Psma4 Psmc1 Psma3 Psmc4 Psmc2 Psma6 Psme1 Psmd1 Psme2 Psmd7 Psmd3 Psmd6 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12%REACTOME%R-RNO-392170.1 ADP signalling through P2Y purinoceptor 12 Gnai3 Gnai2 Gnb3 Gnb5 Gnb2 Gnb1 Gng13 Gng12 Gng11 Gnat3 LOC100912034 Gnb4 Gng4 Gnai1 Gngt2 P2ry12 Gng5 Gngt1 Gng10 Gng8 Gng3 SIGNALING BY TGF-BETA FAMILY MEMBERS%REACTOME DATABASE ID RELEASE 66%10145195 Signaling by TGF-beta family members Furin Fstl1 Grem2 Fstl3 Amhr2 Smurf1 Cer1 Nog Foxh1 Tgfbr1 Ube2m E2f5 Cbl Hdac1l Snw1 Tgfbr2 Cgn Acvrl1 Bmp2 Amh Acvr2a Chrdl1 Smad9 Smad5 Smad6 Acvr1c Gdf2 Bmpr2 Tgfb1 Acvr1b Fst Zfyve16 Inhba Drap1 Smad3 Ccnt2 Smad2 Pard6a Nedd8 Fkbp1a Strap Usp9x Sp1 Ube2d1 Skil Rbl1 F11r Ncor2 Cdk9 Mtmr4 E2f4 Zfyve9 Men1 Hdac1 Tgif2 Arhgef18 Tgif1 Atp1b4 Trim33 Pmepa1 Ccnk Ube2d3 Pard3 Bambi Wwtr1 Tfdp1 Prkcz Tfdp2 Stub1 Parp1 Rhoa MITOTIC G2-G2 M PHASES%REACTOME DATABASE ID RELEASE 66%10145075 Mitotic G2-G2 M phases Psmc6 Psmb10 Psmb8 Psmb9 Psmb4 Psmb11 Psmb5 Psmf1 Psmb6 Mnat1 Psmd4 Rbx1 Psmb2 Dync1i2 Psmd5 Psmd8 Cep57 Psmd9 Psmb3 Rab8a Psma8 LOC691918 Psmd11 Psmd12 Haus3 Ccna2 Ccna1 Psmd13 Ninl Psmd14 Akap9 Ccp110 Cdk2 Pafah1b1 Ppp1r12a Psmc3 Ccnh Ajuba Hsp90ab1 Tubb5 Ppp2cb Ppp2ca Ywhag Skp1 Ppp2r1a Ywhae Fbxw11 Cdkn1a Ppp2r1b Nek2l1 Btrc Prkaca Nek2 Ppp2r3b Bora Fbxl18 Fkbpl Fbxl7 Ppme1 Foxm1 Cul1 Lcmt1 Tubgcp2 Aurka Dync1h1 Cdc25c LOC103692716 Ppp1cb Xpo1 Dctn1 Cntrl Dctn2 Cep76 G6pc Pcm1 Cep78 LOC100911033 Cep164 Dctn3 Ofd1 Cep41 Psmb7 Sdccag8 Psmb1 Prkar2b Cenpj Plk4 LOC100912076 Tubg2 Haus2 E2f1 Psma5 Haus1 E2f3 Haus5 Tpx2 Alms1 Cdk11b Clasp1 Haus4 Odf2 Cdk7 LOC100910954 Tubb4a Cdk1 Ssna1 Tubg1 Mapre1 Psma2 Cep63 Csnk1d Psmc5 Gtse1 Cep131 Psmd2 Psma1 Phlda1 Tuba4a Psma4 Cdc25b Cep250 Psmc1 Cdc25a Psma3 Cep135 Wee1 Csnk1e Psmc4 Pkmyt1 Cdk5rap2 Psma6 Psmc2 Ckap5 Ppp2r2a Psme1 Nme7 Tubgcp5 Pcnt Tubgcp6 Psme2 Psmd1 Cep72 Tubgcp3 Sfi1 Psmd7 Tubgcp4 Cep70 Optn Actr1a LOC100909844 Mzt1 Nedd1 Psmd3 Mzt2b Psmd6 SIGNALLING TO ERK5%REACTOME DATABASE ID RELEASE 66%10145365 Signalling to ERK5 LOC100912585 Mapk7 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS.%REACTOME%R-RNO-163200.1 Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. Ndufab1 Mt-nd4 Atp5f1 Ndufa7l Mt-nd5 Etfa Ndufaf7 Etfb Ndufa7 LOC683884 Ndufaf5 Mt-nd6 Nubpl Mt-nd2 LOC100911483 Ndufb10 Ndufb11 Ndufa12 Ndufa11 Mt-atp6 Ndufa13 Ndufa10 Ndufb6 Ndufb3 LOC100912599 Ndufb5 LOC100361505 Ndufc2 Ndufb9 Ndufb4 Ndufb8 Ndufb7 Ndufaf3 Atp5j2 Ndufaf1 Ndufa2 Ndufa5 Ndufaf4 Ndufa6 Mt-atp8 RGD1306782 Ndufa1 Ndufs3 LOC500350 Ndufs1 Ndufs4 Atp5g3 Ndufs5 Ndufs2 Ndufs8 Coq10a Ndufs6 Ndufs7 Timmdc1 Atp5g2 LOC684509 Acad9 Ndufb2 LOC679739 LOC100911417 Etfdh LOC679195 LOC100910710 LOC680288 Ucp2 Ecsit LOC688963 Ucp3 LOC100909612 Slc25a14 Atp5l Ucp1 Atp5o Atp5h Tmem126b Atp5i Atp5j LOC100363268 Ndufv3 LOC100361144 Ndufv1 Ndufv2 Atp5s Atp5e Atp5d Atp5b MYD88:MAL(TIRAP) CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME%R-RNO-166058.1 MyD88:MAL(TIRAP) cascade initiated on plasma membrane Map2k7 Ripk2 Map2k6 Ager Dusp3 Map2k4 Map3k8 Dusp4 Peli3 Nfkbib LOC100912399 Peli2 Map3k1 Traf6 Cul1 Vrk3 Rps6ka2 Rps6ka1 App Rps6ka3 Rps6ka5 Tirap LOC100912585 Tab1 Dusp7 Dusp6 Rela Atf1 Atf2 Map3k7 Peli1 Irak2 Nfkbia LOC100910771 Ube2n Jun Ppp2cb Ppp2ca Skp1 Ppp2r1a Nfkb2 Nfkb1 Mapk9 Mapk8 Fos S100b Mapk7 Dhx9 Fbxw11 Chuk Ppp2r1b Ecsit Mapkapk3 Btrc Mapkapk2 Mapk1 Nkiras1 LOC100362142 Nod1 Nod2 Nkiras2 Creb1 Tab2 Tab3 LOC100912618 Ube2v1 Ikbkb Mapk14 Myd88 Tnip2 Mapk11 Mapk10 FORMATION OF THE ACTIVE COFACTOR, UDP-GLUCURONATE%REACTOME DATABASE ID RELEASE 66%10144771 Formation of the active cofactor, UDP-glucuronate Ugdh Slc35d1 Ugp2 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK%REACTOME DATABASE ID RELEASE 66%10145366 Gastrin-CREB signalling pathway via PKC and MAPK Kras Mapk7 Egfr Hbegf Cckbr Mapk1 Gast Rps6ka2 Rps6ka1 Rps6ka3 Creb1 LOC100912585 Prkca Hras Nras Sos1 Grb2 INTRACELLULAR OXYGEN TRANSPORT%REACTOME%R-RNO-8981607.1 Intracellular oxygen transport Cygb Mb NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS%REACTOME DATABASE ID RELEASE 66%10145178 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Ripk2 Map2k6 Birc3 Birc2 Aim2 Cyld Hsp90ab1 Traf6 Panx1 Tab1 Sugt1 Casp4 Casp1 Casp2 Bcl2 Nlrp1a Txnip Mefv Map3k7 Pstpip1 Casp8 Irak2 Tnfaip3 P2rx7 Casp9 Nlrp3 Mapk13 Mapk12 Chuk Txn1 LOC100362142 Nod1 Nod2 LOC100910771 Tab2 Ube2n Tab3 LOC100912618 Pycard Ube2v1 Ikbkb Mapk14 Mapk11 VITAMINS B6 ACTIVATION TO PYRIDOXAL PHOSPHATE%REACTOME%R-RNO-964975.1 Vitamins B6 activation to pyridoxal phosphate Pdxk Aox1 Pnpo SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION%REACTOME DATABASE ID RELEASE 66%10145592 Sema4D mediated inhibition of cell attachment and migration Rras Rhoa Sema4d Plxnb1 Rnd1 Rac1 Arhgap35 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2%REACTOME%R-RNO-5140745.1 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 Cltb Ap2a2 Clta Fzd2 Ap2s1 Wnt5a Ap2a1 Ror1 Ror2 Ap2m1 Cltc RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME%R-RNO-110381.1 Resolution of AP sites via the single-nucleotide replacement pathway Xrcc1 Lig3 Apex1 Polb SCAVENGING BY CLASS B RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145958 Scavenging by Class B Receptors LOC685953 Scarb1 Cd36 Apob Apoa1 RGD1565355 REGULATION OF TLR BY ENDOGENOUS LIGAND%REACTOME DATABASE ID RELEASE 66%10146066 Regulation of TLR by endogenous ligand LOC685953 Cd14 Cd36 Apob Tlr4 Lbp RGD1565355 Tlr6 Tlr2 Tlr10 NOTCH-HLH TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 66%10145446 Notch-HLH transcription pathway Notch1 Notch2 Maml1 Notch4 Rbpj Crebbp Notch3 Kat2a Snw1 Rbpjl2 VITAMINS%REACTOME%R-RNO-211916.1 Vitamins Cyp27b1 Cyp2r1 Cyp24a1 Cyp26a1 Cyp26c1 Cyp26b1 UCH PROTEINASES%REACTOME DATABASE ID RELEASE 66%10146120 UCH proteinases Psmc6 Bard1 Psmb10 Psmb8 Psmb9 Psmb4 Psmb11 Psmb5 Yy1 Psmf1 Psmb6 Psmd4 Psmb2 Psmd5 Psmd8 Actr8 Psmd9 Psmb3 Psma8 Psmd11 Psmd12 Psmd13 Psmd14 Actl6a Mcrs1 Actb Ino80 Uchl3 Psmc3 Bap1 Senp8 RGD1561252 Asxl2 Ogt Foxk2 Uchl5 Ruvbl1 Adrm1 Uchl1 Nedd8 G6pc Psmb7 Psmb1 Ino80e Ino80d Nfrkb Psma5 Psma2 Psmc5 Psmd2 Psma1 Psma4 Psmc1 Psma3 Psmc4 Psmc2 Psma6 Psme1 Psmd1 Psme2 Psmd7 Ino80b Psmd3 Ino80c Psmd6 ADRENOCEPTORS%REACTOME%R-RNO-390696.1 Adrenoceptors Adra2a Adra1d Adra2c Adra2b Adra1a Adrb3 Adrb2 REGULATION OF TP53 EXPRESSION%REACTOME DATABASE ID RELEASE 66%10146179 Regulation of TP53 Expression LOC100910954 POST-TRANSLATIONAL PROTEIN MODIFICATION%REACTOME%R-RNO-597592.1 Post-translational protein modification Usp7 Ddb2 Pias3 Pias1 Yy1 Ddb1 Rbx1 Actr8 Stag1 Rad21 Smc1a Stag2 Smc3 Actl6a Mcrs1 Cops8 Cops2 Actb Sumo1 Sumo3 Ino80 Pcna Cul4b Cul4a Ube2v2 Xpc Ube2n Ube2i Ruvbl1 Hist1h2aa Ercc8 Rpa1 Cops4 Cops6 Cops3 Ripk2 Traf6 Cul1 Commd9 App Tab1 Rela Map3k7 Cd59 Ctsa Stam2 Plaur Nfkbia LOC100910771 Cst3 Muc20 Qsox1 Stam Rab4a Fcgr3a Ctsc C4a C4b Ctsz Mlec LOC100909666 LOC102549354 Psmb7 Psmb1 Ino80e Ino80d Nfrkb Psma5 Parp1 Rad23a Rad23b Cops7b Cops7a Psma2 Psmd2 Commd3 Bst1 Psmc2 Psmd1 Psmd7 Ino80b Psmd3 Ino80c Psmd6 Ccdc22 Fbxl19 Fbxl12 Fbxl13 Fbxl16 Fbxl15 Tgfa Prnd Eif5a Pex2 Derl1 Csf1 Ttll10 Clspn Rad18 Wfs1 Pex5 Ube2z Dcun1d5 Dcun1d4 Dcun1d3 Ube2t Ube2s Ttll9 LOC100909521 Ttll4 Ttll5 Ttll3 Ttll7 Ttll2 Nae1 Fbxl4 Fbxl5 F8 Scfd1 F7 F9 Ttll12 Fbxl8 Rbbp5 Skp1 Tnks Phc1 Phc2 Nfkb2 Fbxw11 Tfap2c Btrc Nod1 Nod2 Tnip2 Rxra Apol2 Prmt3 Hsp90b1 RGD1309808 Apol11a Apol3 LOC100910885 Apol9a Hist1h2bo Scmh1 Hist1h2bcl1 Cbx4 Hist1h2bk Cbx2 Cbx8 Bmi1 Hdac2 Rnf2 Usp13 Ring1 Phc3 Ogt Tnks2 Mta1 LOC100910717 LOC100910200 Hist1h4b Wdr5 Hist1h2bh Dnmt1 LOC100912290 Rbbp7 Hist1h4m LOC100912338 Dnmt3b Hist2h4 Hist2h2aa3 Hist1h2bq Hist2h2aa2 LOC100364835 Hist1h2bg LOC680097 LOC684797 LOC100912418 Hist1h2ba Mgat2 Mgat5 Mettl20 Mettl22 Sec24a Sec24b Copa Sec24d Mysm1 Asb18 Mgat3 Asb11 Asb12 Mgat1 Asb13 Asb14 Asb10 Keap1 Wdtc1 Fkbp8 Man1c1 Asb15 Asb17 Asb16 Adamts1 Man1a1 Adamts6 Adamts7 Uimc1 Adamts9 Sspo Cyr61 Cog4 Cog6 Cog8 Cog3 Ntng1 Ntng2 Cog1 Cog2 Chgb Igfbp1 Sec23ip Lman1l Igfbp5 Cog7 LOC102555167 Igfbp4 Alpl Kng1l1 Afp Cand1 Rab39a Mul1 Mfge8 Rab11b Ptp4a2 Cpm Thsd1 Ykt6 Sec24c Paf1 Igfbp7 Rfwd2 Notum Tmed7 Tmed3 LOC100911393 Tmed2 Eef2kmt Tex101 Aplp2 Rab6b Rab9a Napg Napb Napa Rtf1 Senp5 Mepe LOC100910849 Pigm Pigk Tmed9 Pigl Pigg LOC100911374 Pigh Nsf Dcaf11 Pigc Dcaf13 Pigb Piga Ankrd9 Dcaf10 Rab8b Pex14 Pex10 Pex13 Pex12 Fbxl22 Lrrc41 Usp47 Ube2c Usp48 Skp2 Fbxw10 Usp42 Chm Fbxw12 Ngly1 Fn3k Arcn1 Rab7b Becn1 Traf2 Pigw Pigv Pigy Pigx Rab33a Rab33b Pign Pigq Pigp Mxra8 Pigs Nucb1 Pigu Pigt Usp20 Usp26 Ggcx Usp21 Obsl1 Usp22 Rab2a Rab2b Trappc10 LOC100910410 Rab35 Rab34 Ly6g6c Rab36 Rabggta Usp19 Spon2 Spon1 Fn3krp Usp37 Il33 Ppp6c Manea Rab3c Rab3b Usp30 Vgf Neurl2 Trappc2l Rab43 Usp24 Usp25 Rab25 Stc2 Rab20 Rab21 Rab19 Prss41 Vdac1 Engase Rab23 Prss23 Prss21 Trappc6a Trappc6b Rab15 Rab12 Rab13 Ankrd28 Rabggtb Rab32 Rab30 Ly6g6d Usp14 Rab38 Usp18 Usp15 Rab1b Rab1a Usp11 Usp10 Tmem115 Ufd1l Sbspon Spaca4 Arfgap2 Dph1 Dcaf8 Atxn3 Dph3 Gpihbp1 Golgb1 Dph2 Klhl5 Arfgap3 Atxn7 Dcaf4 Sparcl1 Arfgap1 Dph5 Dph6 Ubxn1 Otoa LOC690251 LOC100910472 Penk Mcfd2 Preb Chst10 Kng1 Capzb Vdac2 Klhl2 Foxo4 Fbxo2 Eva1a Kng2 Fbxo9 Fbxo7 Cdh2 Rwdd3 Fbxo6 Fbxo4 Proz Cul9 Dcun1d2 Ube2k Plet1 Ube2h Ube2f Sec31a Ube2a Stx17 Pomt2 Pomgnt2 Dcaf7 Pomt1 Pros1 Klhl9 Dcaf5 Dcaf6 Dda1 Bglap Lrr1 Dhps Gosr2 Gosr1 Tmed10 Pomgnt1 Hrc Wdr20 Areg Stx5 Bet1 Arf5 Etfb Cnih1 Shisa5 Fuca2 Rnf123 Pofut2 Mfi2 Wdr48 Izumo1r Bre Cish Arf4 Bpifb2 Ctage5 Asgr1 Large Brcc3 Gyltl1b Rab27a Ccnf Psmd11 Gbf1 Psmd12 Ube2e3 Ccna2 Ctr9 Ccna1 Cnih3 Psmd13 Cnih2 Psmd14 Dtl Asgr2 Amtn Rab7l1 Wdr61 Commd7 Commd2 Cfp Commd1 Man2a1 Fut8 Serpind1 Man2a2 Rps2 Sprn Sema5b Tceb2 Mgat4b Tceb1 Commd4 Cul2 Commd5 Hif1a Mgat4a Commd6 Rnf152 Psmc3 Enam Fem1b Fem1a Serpinc1 Epas1 Ptrh2 Tada3 Hif3a Copz2 Copz1 Bcl10 Reck Lman2 Sec16a Sec16b Lman1 LOC102554393 Rnf181 Trappc2 Kctd7 Trappc5 Calu Bmp15 Rnf7 Kin Cd109 Rab27b Babam1 Fem1c Rab3a Josd2 Copb1 Josd1 Suds3 Opcml Eif5a2 Chst8 Rab7a Thy1 Tfg Tada2b Ly6e Ly6d Psca Ly6h Kbtbd8 Otulin Rab22a Rab4b Kbtbd7 Kbtbd6 Gpld1 Neu1 Trappc3 Kctd6 Mettl21a Arsi Pcsk9 LOC100910318 Arse Ube2q2 Hltf Arsg Ube2r2 Rab5b Kdelr1 Amelx Rab5c Rce1 Arsk Tbc1d20 Sts Capza2 Capza3 LOC100910143 Rab6a Commd10 Sumf2 Gan Sumf1 B3galnt2 Tecta Thsd7a Vnn3 Fam20c Usp3 Usp4 Usp5 Stambpl1 Kdelr2 Tmem132a LOC100911959 Thsd7b Lgals1 Rab9b Ppp6r3 Trappc1 Ppp6r1 Kdelr3 Tectb Art3 Fam20a Art4 Adamts13 Apc Otub1 Adamts15 Otud3 Ide Otud7b Hist2h2ab Adamts19 LOC100910557 Adamts16 Adamts17 Pomk Sptan1 Ambn Vcp Gas6 Adamts12 Rab18 Asb5 Asb6 Asb7 Msln Rab10 Klhl41 Rab14 Asb1 Asb3 Vnn1 Cdc34 Rab24 Zranb1 Asb8 Ripk1 Actr10 Rtn4rl2 Vcpip1 Ifih1 Tnip1 Klhl42 Gpaa1 Arsa RGD1565607 Otub2 LOC100911993 Tnfaip3 Rtn4rl1 Dync1h1 Tdg Lypd5 Nr5a2 Lypd8 Lypd1 Lypd6b Lypd2 Lypd3 Lypd4 LOC102553119 Dync1li1 LOC689730 Fbxo41 Bmyc Thbs2 Fbxo44 Polb Fbxo40 Wsb2 Copg1 Wsb1 Spsb3 Dctn5 Esr1 Dctn6 Spsb2 Adamtsl2 Spsb1 Gata3 Adamtsl3 Shprh Ddx5 Rnf20 Adamtsl4 Folr2 Nrip1 Rab3d Dctn4 Pgr Spsb4 Ncoa1 Folr1 Scg2 Btbd1 Btbd6 Fbxo22 Ube2g2 Ube2g1 Dohh Uso1 Scg3 Il6 Klhl13 Fbxo30 Gorasp1 Fbxo31 Klhl11 Fbxo32 Fbxo21 LOC100910107 Ddx58 St8sia1 Alg1 Klhl20 Gfpt2 Cntn4 Nus1 Cntn3 Alg2 Cntn5 Dolpp1 Pgap1 Gfpt1 Sae1 Rnf40 St8sia3 Alg6 Fam175b Alg3 Rcn1 Alg9 Zbtb16 Alg8 Klhl25 Klhl21 Uba1 Klhl22 Uba2 Renbp Fbxo10 Rab40c St3gal5 Mpi Usp2 Rab40b Pgm3 Icmt Pmm2 Fam175a Alg14 Fbxo15 Pmm1 Tulp4 Alg12 Fbxo11 Dnajc3 Daxx Sec22b Slc35a1 LOC100910954 Cope St8sia5 Cdk1 Sec23a St6galnac1 Mdm4 C3 Fbxw2 St6galnac2 Nudt14 Uba6 LOC501189 Taf10 Gp2 St8sia4 LOC100910177 Sec22a Senp2 Dolk St6gal1 Fbxw9 Uba3 St6gal2 Nub1 Amdhd2 Senp1 Rhoa Fbxw5 St6galnac4 Eef2 Fbxw4 St6galnac3 Nagk Fbxw8 Gne Fbxw7 Mpdu1 Man1a2 Dpagt1 LOC103690024 Xpnpep2 St6galnac6 Gnpnat1 LOC100912059 Dpm3 Ckap4 Serpina10 Dpm2 LOC100363782 Dpm1 Usp17l5 Uap1 Taf9b Trim27 Mdm2 Vhl Socs5 Socs3 Leo1 Vwa1 Stambp Commd8 Socs6 Pias4 Pml Pias2 Brca1 Blm Mdc1 Zfp131 Pcgf2 Hdac4 Uhrf2 Foxl2 Satb2 Satb1 Topors Usp8 Thra Thrb Fuom Nsmce1 Smad3 Slc35c1 Ing2 Nsmce2 Smad2 Mbd1 Nedd8 Nr1h3 Nr1h2 Top1 Usp9x Safb Park7 Ube2d1 Smc6 Tp53bp1 Fuk Smc5 Nr5a1 Tsta3 Rora Gmds LOC100911225 Nr1i2 Rad52 Fpgt Mitf Hdac1 Herc2 Xrcc4 LOC100911274 Timp1 Ube2d3 Edem3 Calr Man1b1 Rnf139 Ganab Edem2 Uggt1 Dmp1 Trim13 Rnf5 Prkcsh B3gnt6 Galntl5 Galnt6 Galnt5 B3gnt8 Muc1 B3gnt5 Chst4 Galnt1 Galnt7 Ceacam10 Galnt3 Galnt2 Canx Lamc1 Rnf103 March6 Fbn1 Ceacam1 Ikbke Fgg Traf3 Siah2 Thbs1 Sar1b Apob Apoe Fga Apoa2 Lamb1 Dag1 Lamb2 Spp1 Ank1 Nop58 Adamts4 Adamts3 Adamts5 Sema5a Spta1 Fn1 P4hb Adamts14 Nans Sptbn1 Npl Dhdds Cmas Ltbp1 Nanp Bard1 Pten Lhb Rab8a Ccp110 Furin Alpp Alpi Mvd Bmp4 Col7a1 F2 Cga Neu4 Neu2 Neu3 Srd5a3 Sin3a Rraga Galnt9 LOC102550196 Gcnt1 A4gnt Muc13 C1galt1 Muc15 C1galt1c1 Galnt16 Galnt18 Galnt14 Galnt15 Galnt12 Galnt13 B3gntl1 Galnt10 Tgfbr1 Ube2m Hdac1l Dctn1 Cdc73 Dctn2 Dctn3 Os9 Usp33 Slc17a5 Rab11a Arrb1 Csnk1d Arrb2 Actr1a Sel1l Nr1h4 Mbtps1 Dync1li2 Kat2a Dync1i2 Dynll2 Tomm70a Dync1i1 Tomm20 Birc5 Apoa1 Nup88 Hipk2 B3gnt4 B3gnt7 B3gnt1 Alppl2 B3gnt2 B3gnt3 Nup85 Nlrp3 Rae1 Glb1 Pnpla2 St3gal2 St3gal3 St3gal1 St3gal4 St3gal6 Nup93 Nup98 Nup107 Nup210 LOC100911750 Ppara Nupl2 Nupl1 Cdca8 Rangap1 B4galt1 Aurkb B4galt3 Sec13 B4galt2 B4galt6 B4galt4 B4galt5 Nup205 Incenp G6pc Ktn1 Nup155 Cdc20 Men1 LOC100911615 Nup153 Vcan Tpr Arsb Mkl1 Nup54 Pom121 Nup62 Cp Psmc6 Psmb10 Nup43 Nup133 Psmb8 Psmb9 Psmb4 Psmb11 Aaas Psmb5 Psmf1 Psmb6 Psmd4 Psmb2 Psmd5 Psmd8 Npap60 Psmd9 Psmb3 Nup35 Psma8 Nup37 Sdc2 Rhot1 Uchl3 Bap1 Senp8 RGD1561252 Asxl2 Foxk2 Uchl5 Ranbp2 Adrm1 Mat2b Uchl1 Fbxl18 Fbxl7 Tgoln2 Fgf23 Tf Fstl1 Fstl3 Chrdl1 Ins1 Ins2 Birc3 Birc2 Cyld Psmc5 Psma1 Psma4 Psmc1 Cdc25a Psma3 Psmc4 Psma6 Psme1 Psme2 LOC100909844 Adrb2 FGFR1B LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 66%10145285 FGFR1b ligand binding and activation Fgf22 Fgf1 Fgf3 Fgf10 Fgf2 Fgfr1 HOMOLOGY DIRECTED REPAIR%REACTOME DATABASE ID RELEASE 66%10144914 Homology Directed Repair Rfc1 Rhno1 Rfc2 Bard1 Wrn Topbp1 Rbbp8 Rmi1 Pole2 Rmi2 Rad51c Pole4 Polh LOC100911267 Spidr Rad51d Eme2 Rad51 Brca2 Eme1 Polq Rtel1 Rad50 Ppp4r2 Ppp4c Ccna2 Ccna1 Atm Atrip LOC100909750 Cdk2 Rpa3 Lig3 Pole Pcna Xrcc3 Brca1 Rad1 Blm Atr Slx4 Mus81 Slx1b Rad17 Palb2 Sirt6 Gen1 Rfc5 Xrcc2 Rfc4 Rad9a Nbn Rfc3 Abl1 Rad9b Mre11a Hus1 Rad52 Rpa1 Rpa2 Ercc1 Xrcc1 Parp2 Parp1 Pold2 Pold1 Pold4 Slc25a16 Fen1 TRANSCRIPTION-COUPLED NUCLEOTIDE EXCISION REPAIR (TC-NER)%REACTOME%R-RNO-6781827.1 Transcription-Coupled Nucleotide Excision Repair (TC-NER) Rfc1 Rfc2 Gtf2h1 Gtf2h2 Usp7 Pole2 Pole4 Ppie Ddb1 Mnat1 Rbx1 RGD1565904 Isy1 Polr2g Polr2h Polr2e Polr2f Polr2j Polr2k Polr2d Polr2i Polr2b Polr2c Polr2a Xab2 Cops8 LOC100912534 Cops2 Rpa3 Lig3 Zfp830 Pole Prpf19 Tcea1 Pcna Cul4b Uvssa Ccnh Cul4a Hmgn1 Xpa Gtf2h3 Rfc5 Rfc4 Rfc3 Gtf2h5 Gtf2h4 Ercc5 Ercc8 Ercc3 Ercc6 Rpa1 Rpa2 LOC100911295 LOC100911822 Cops4 Aqr Cops6 Ercc2 Ercc1 Lig1 Cops3 Xrcc1 LOC100911727 Cdk7 Cops7b Cops7a Pold2 Pold1 Pold4 TRANSCRIPTIONAL REGULATION BY RUNX2%REACTOME DATABASE ID RELEASE 66%10146258 Transcriptional regulation by RUNX2 Psmc6 Psmb10 Psmb8 Psmb9 Psmb4 Psmb5 Psmf1 Psmb6 Psmd4 Rbx1 Cul1 Psmb2 Psmd5 Psmd8 Psmd9 Psmb3 Psmd11 Psmd12 Psmd13 Psmd14 Psmc3 Cbfb Ppm1d Rbm14 LOC100911677 Sox9 G6pc Cdk4 Psmb7 Psmb1 Ccnd1 Skp1 Stub1 Psma5 Runx2 Skp2 Cdk1 Psma2 Psmc5 Psmd2 Psma1 Psma4 Psmc1 Psma3 Psmc4 Psmc2 Psma6 Psme1 Psmd1 Psme2 Psmd7 Psmd3 Psmd6 PRE-NOTCH PROCESSING IN GOLGI%REACTOME%R-RNO-1912420.1 Pre-NOTCH Processing in Golgi Notch1 Tmed2 Notch2 Notch4 Notch3 Furin CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA%REACTOME DATABASE ID RELEASE 66%10145175 Cytosolic sensors of pathogen-associated DNA Nlrp4 Dtx4 Tbk1 Ager Ddx41 Nlrp4a Irf3 Trim21 Trim32 Nfkbib App Rela Nfkb2 Nfkb1 S100b Dhx9 Stat6 Chuk Dhx36 Nkiras1 Nfkbia Nkiras2 Tmem173 Ikbkb Crebbp Myd88 Mre11a HDL ASSEMBLY%REACTOME DATABASE ID RELEASE 66%10145449 HDL assembly Prkaca Prkacb Bmp1 Abca1 A2m Apoa1 Zdhhc8 ERYTHROCYTES TAKE UP OXYGEN AND RELEASE CARBON DIOXIDE%REACTOME DATABASE ID RELEASE 66%10145820 Erythrocytes take up oxygen and release carbon dioxide Rhag Hbb-b1 Hba1 Car2 Aqp1 Slc4a1 Car1 LOC287167 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN%REACTOME%R-RNO-1234174.1 Regulation of Hypoxia-inducible Factor (HIF) by oxygen Psmc6 Psmb10 Hif1an Psmb8 Vhl Psmb9 Psmb4 Psmb11 Psmb5 Psmf1 Psmb6 Psmd4 Psmb2 Rbx1 Psmd5 Psmd8 Psmd9 Psmb3 Psma8 Psmd11 Psmd12 Psmd13 Psmd14 Egln2 Tceb2 Tceb1 Cul2 Cited2 Hif1a Limd1 Psmc3 Epas1 Hif3a Egln3 Ajuba Crebbp G6pc Ube2d1 Psmb7 Psmb1 Ube2d3 Psma5 Arnt Psma2 Psmc5 Psmd2 Psma1 Psma4 Psmc1 Psma3 Psmc4 Psmc2 Psma6 Psme1 Psmd1 Psme2 Psmd7 Psmd3 Psmd6 PHASE 2 - PLATEAU PHASE%REACTOME%R-RNO-5576893.1 Phase 2 - plateau phase Cacna1c Cacng7 Cacna1d Cacng1 Kcne1 Kcne2 Cacng5 Kcne4 Kcne3 Cacnb4 Cacng8 Cacnb1 Cacnb2 Kcnq1 Cacna2d3 Cacna1f Kcne5 Cacna1s Cacng2 Cacng3 Cacna2d2 Cacna2d4 Cacng4 Akap9 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER%REACTOME%R-RNO-6782210.1 Gap-filling DNA repair synthesis and ligation in TC-NER Rfc1 Rfc2 Gtf2h1 Gtf2h2 Usp7 Pole2 Pole4 Ppie Ddb1 Mnat1 Rbx1 RGD1565904 Isy1 Polr2g Polr2h Polr2e Polr2f Polr2j Polr2k Polr2d Polr2i Polr2b Polr2c Polr2a Xab2 LOC100912534 Rpa3 Lig3 Zfp830 Pole Prpf19 Tcea1 Pcna Cul4b Uvssa Ccnh Cul4a Hmgn1 Gtf2h3 Rfc5 Rfc4 Rfc3 Gtf2h5 Gtf2h4 Ercc8 Ercc3 Ercc6 Rpa1 Rpa2 LOC100911295 LOC100911822 Aqr Ercc2 Lig1 Xrcc1 LOC100911727 Cdk7 Pold2 Pold1 Pold4 RHO GTPASE CYCLE%REACTOME DATABASE ID RELEASE 66%10145340 Rho GTPase cycle Arhgap18 Arhgap19 Arhgap21 Arhgap17 Racgap1 Myo9a Arhgap22 Arhgap10 Arhgap20 Srgap1 Srgap3 Arhgap39 Rhobtb2 Arhgap36 Rac1 Depdc1b Arhgap44 Arhgap35 Arhgap5 Arhgap6 Arhgdib Rhoj Ralbp1 Rhoh Depdc7 Arhgap11a Dlc1 Syde1 Syde2 Fam13a Fam13b Gmip Arhgap15 Arhgap12 Arap1 Inpp5b Stard13 Tagap Chn2 Stard8 Ophn1 Arhgap1 Arhgap8 Rhot2 Rhot1 Srgap2 A2m Arhgap26 Arhgap25 Arhgap29 Arhgap23 Arhgap28 Arhgap27 Arhgap42 Arhgap40 Arhgap32 Rhob Arhgap30 Rhoc Arhgap31 Gdi2 Hmha1 Rac2 Ocrl Arhgef6 Rhod Arhgef5 Arhgef39 Arhgef7 Arhgef37 Arhgef38 Rhoq Arhgef33 Pik3r2 Prex1 Itsn1 Arhgef2 LOC102556447 Arhgef4 Arhgef3 Plekhg5 Arhgef19 Arhgef18 Plekhg2 Kalrn LOC100912512 LOC687609 Myo9b Vav2 Gna13 Vav1 Arhgef11 Akap13 Arhgef16 Arhgef15 Net1 Ect2 Arhgef26 Fgd2 Mcf2l Tiam1 Tiam2 Vav3 Arhgap9 Fgd3 Sos2 Ngef Cdc42 Rhoa Arhgdia Rhof Rhog Sos1 GLUTATHIONE CONJUGATION%REACTOME%R-RNO-156590.1 Glutathione conjugation Gstp1 Gsto1 Gstm7 Ggct Esd Gclm Gstm5 Gsto2 Gstk1 Cndp2 Gclc LOC100912430 Gstt2 Ggt7 Ggt6 Chac2 Chac1 Mgst3 Oplah Gstz1 Gsta5 Gss Akr1a1 Hpgds Gstm4 Mgst1 PTK6 DOWN-REGULATION%REACTOME DATABASE ID RELEASE 66%10146208 PTK6 Down-Regulation Srms Ptpn1 Ptk6 TP53 REGULATES TRANSCRIPTION OF SEVERAL ADDITIONAL CELL DEATH GENES WHOSE SPECIFIC ROLES IN P53-DEPENDENT APOPTOSIS REMAIN UNCERTAIN%REACTOME DATABASE ID RELEASE 66%10146175 TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain Rabggtb Chm Rabggta CYCLIN A B1 B2 ASSOCIATED EVENTS DURING G2 M TRANSITION%REACTOME%R-RNO-69273.1 Cyclin A B1 B2 associated events during G2 M transition Cdk2 Ppp2r3b Cdc25c Cdk7 Ppp2r1b Cdk1 Ppme1 Mnat1 Foxm1 Lcmt1 Ccnh Cdc25b Xpo1 Cdc25a Wee1 Ppp2cb Ppp2ca Pkmyt1 Ppp2r2a Ppp2r1a Ccna2 Ccna1 SPHINGOLIPID METABOLISM%REACTOME%R-RNO-428157.1 Sphingolipid metabolism Psap Sgpl1 Kdsr Fa2h Ppap2a Arsa Ppap2b Sgpp2 Sptssb Ctsa Sptssa Aldh3b1 LOC498300 Cers4 Cers3 Cers6 RGD1564463 Csnk1g2 Osbp Hexb Hexa Asah1 Cers1 Acer2 Acer1 Acer3 Cers2 Vapa Neu4 Degs2 Neu2 Gdf1 Gltp Sptlc3 Sptlc1 B4galnt1 Prkd3 Neu3 Sptlc2 Cerk Enpp7 Prkd1 Gba Neu1 Prkd2 Galc Asah2 Arsi Sgms1 Vapb Smpd1 Arse Ormdl1 Cptp Arsg Smpd2 Esyt3 Gla Smpd3 Arsk Glb1l Sts Aldh3a2 Esyt2 Sphk2 Arsb Smpd4 Gba2 Col4a3bp Ormdl2 Sumf2 Sumf1 B3galnt1 Ppap2c Ugt8 Glb1 Ugcg Samd8 Gm2a Degs1 SPERM:OOCYTE MEMBRANE BINDING%REACTOME DATABASE ID RELEASE 66%10145840 Sperm:Oocyte Membrane Binding Izumo3 Izumo1 LOC100911976 Izumo4 Izumo2 Cd9 CRISTAE FORMATION%REACTOME%R-RNO-8949613.1 Cristae formation LOC100911417 Atp5f1 LOC500350 Atp5g3 Atp5l Atp5g2 Atp5o Atp5h Mt-atp6 Atp5i Atp5j Atp5j2 Atp5s Atp5e Atp5d Mt-atp8 Atp5b AROMATIC AMINES CAN BE N-HYDROXYLATED OR N-DEALKYLATED BY CYP1A2%REACTOME%R-RNO-211957.1 Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 Cyp1a2 ABACAVIR TRANSPORT AND METABOLISM%REACTOME DATABASE ID RELEASE 66%10145942 Abacavir transport and metabolism Nt5c2 Adal Adh6 Slc22a1 Slc22a2 Slc22a3 REGULATION OF CYTOSKELETAL REMODELING AND CELL SPREADING BY IPP COMPLEX COMPONENTS%REACTOME DATABASE ID RELEASE 66%10145641 Regulation of cytoskeletal remodeling and cell spreading by IPP complex components Arhgef6 Rsu1 Actn1 Parvb Lims1 PHOSPHOLIPASE C-MEDIATED CASCADE; FGFR3%REACTOME DATABASE ID RELEASE 66%10146099 Phospholipase C-mediated cascade; FGFR3 Fgf23 Fgf4 Fgf1 Fgf16 Fgf17 Plcg1 Fgf5 Fgf9 Fgf2 Fgf8 Fgfr3 Fgf20 RAF MAP KINASE CASCADE%REACTOME%R-RNO-5673001.1 RAF MAP kinase cascade Ereg Nrg1 Btc LOC102552659 Erbb3 Erbb2 Nrg3 Egfr Hbegf Nrg4 Fyn Ptk2 Nrg2 Shc2 Ranbp9 Pdgfa Pdgfb Tln1 Vwf Apbb1ip Rasa1 Dlg4 Grin2d Camk2g Grin2b Grin1 Nefl Rasgrf1 Dusp4 Dlg1 Dlg2 Frs3 Dlg3 Camk2d Actn2 Camk2a Dusp7 Dusp6 Fgb Ret Fgg LOC100909468 Hgf Fga Gdnf Map2k2 Pspn Ppp2r5e Il2rg G6pc Pdgfra Pdgfrb Psmb7 Psmb1 Ppp2r5c Spta1 Lrrc7 Ppp2r5a Gfra4 Gfra3 Ppp2r5b Gfra2 Pbp2 Fn1 Artn Dusp9 Dusp2 Shc3 Dusp5 Nrtn Rasal3 Psma5 Ptpra Csk Rasal1 Rasal2 Rasgrp1 Rap1a Pebp1 Ncam1 Rasgrp4 Sptbn1 Rasgrp3 Pea15 Dusp1 Mark3 Psma2 Araf Rasa4 Psmd2 Il5 Spred1 Spred2 Rasgef1a Il2 Psmc2 Rasa2 Rasa3 Itga2b Il2ra Csf2 Psmd1 Psmd7 Il3ra Nf1 Iqgap1 Kit Syngap1 Psmd3 Kitlg Psmd6 Il2rb Dusp16 Psmc6 Map3k11 Csf2ra Psmb10 Csf2rb Ksr1 Rapgef2 Psmb8 Wdr83 Psmb9 Ksr2 Raf1 Psmb4 Ppp5c Psmb11 Psmb5 Il17rd Psmf1 Il5ra Psmb6 Cnksr1 Psmd4 Cnksr2 Psmb2 Dusp10 Psmd5 Paqr3 Psmd8 Psmd9 Psmb3 Psma8 Psmd11 Psmd12 Psmd13 Psmd14 Fgf2 Psmc3 Src Ppp2cb Ppp2ca Ppp2r1a Ywhab Ppp2r1b Mapk1 Jak3 Jak1 Vcl Sptan1 Fgf23 Fgf22 Fgf4 Fgf1 Fgf3 Fgf6 Fgf5 Lamtor3 Fgf20 Fgf16 Lamtor2 Fgf17 Irs2 Fgf10 Fgf9 Fgfr2 Fgf7 Fgf8 Fgfr3 Fgfr1 Fgfr4 Fgf19 Erbb4 Irs1 Frs2 Kras Psmc5 Arrb1 Psma1 Tek Psma4 Psmc1 Arrb2 Psma3 Psmc4 Psma6 Lat Psme1 Angpt1 Hras Psme2 Nras Sos1 Shc1 Grb2 ABASIC SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 66%10144981 Abasic sugar-phosphate removal via the single-nucleotide replacement pathway Apex1 Polb CRMPS IN SEMA3A SIGNALING%REACTOME%R-RNO-399956.1 CRMPs in Sema3A signaling Crmp1 Plxna2 Plxna1 Fyn LOC103692570 Nrp1 Cdk5r1 Cdk5 Dpysl2 Dpysl5 Dpysl4 LOC100910964 Fes Sema3a Dpysl3 REGULATION OF TP53 ACTIVITY THROUGH ACETYLATION%REACTOME DATABASE ID RELEASE 66%10146001 Regulation of TP53 Activity through Acetylation Ing2 Map2k6 Rbbp7 Akt1 Hdac1 LOC364561 Pin1 Brpf3 Brd7 Brpf1 Brd1 Pml Kat6a Ing5 Hdac2 Mbd3 LOC100910954 Chd3 Hdac1l Chd4 Akt3 Mta2 Gatad2a Tmem55b Pip4k2b Pip4k2c Akt2 Meaf6 Gatad2b BIOSYNTHESIS OF MARESINS%REACTOME%R-RNO-9018682.1 Biosynthesis of maresins LOC100361547 Cyp3a23/3a1 Cyp3a73 Cyp2d5 Cyp2c7 Cyp2e1 Cyp2d4 Cyp3a18 Alox5 LOC100910877 Cyp2d2 Ephx2 Cyp1a2 Cyp2d3 Cyp2c6v1 TP53 REGULATES TRANSCRIPTION OF CELL CYCLE GENES%REACTOME%R-RNO-6791312.1 TP53 Regulates Transcription of Cell Cycle Genes Tnks1bp1 Cnot8 Rqcd1 Cnot3 Cenpj Cnot1 Sfn Cnot2 Ccna2 Plk2 Ccna1 Ccne2 Aurka Plk3 Cnot7 Ccne1 Cnot4 Cdk2 E2f7 E2f8 Btg2 Cdc25c Cdkn1a Cdkn1b Cnot6l Cdk1 Cnot11 Pcna Gadd45a Bax PLC BETA MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 66%10144985 PLC beta mediated events Prkcd Plcb1 Gnai3 Plcb3 Gnat3 Pla2g4a Gnao1 Adcy3 Prkar2b Prkar2a Gnat2 Gnaz Pde1b Adcy8 Adcy9 Adcy5 Adcy4 Gnai2 Adcy7 Adcy6 Prkar1b Prkar1a Plcb4 Mapk1 Prkaca Prkacb Gnat1 Prkca Camk4 Adrbk1 Gnai1 REGULATION OF EXPRESSION OF SLITS AND ROBOS%REACTOME DATABASE ID RELEASE 66%10146286 Regulation of expression of SLITs and ROBOs Dag1 Robo1 Usp33 Slit2 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION%REACTOME DATABASE ID RELEASE 66%10145475 GABA synthesis, release, reuptake and degradation Slc6a11 Dnajc5 Slc6a13 Slc6a1 Gad2 Slc6a12 Rab3a Gad1 Abat Aldh5a1 Rims1 Stx1a Cplx1 Syt1 Vamp2 Stxbp1 Slc32a1 INTEGRIN ALPHAIIB BETA3 SIGNALING%REACTOME DATABASE ID RELEASE 66%10145476 Integrin alphaIIb beta3 signaling Fn1 Src Csk Tln1 Crk Rasgrp1 Rasgrp2 Rap1a Vwf Apbb1ip Ptpn1 Bcar1 Fgb Fgg Pdpk1 Akt1 Rapgef4 Fga Itga2b Ptk2 Sos1 Shc1 Syk Grb2 FCERI MEDIATED MAPK ACTIVATION%REACTOME DATABASE ID RELEASE 66%10145166 FCERI mediated MAPK activation Map2k7 Kras Map2k4 LOC100912399 Map3k1 Rac1 Jun Vav2 Vav1 Mapk9 Mapk8 Fos Vav3 Mapk1 Pak2 Pak1 Lat Plcg1 Lyn Hras Nras Sos1 Lcp2 Syk Shc1 Grb2 Mapk10 PTK6 ACTIVATES STAT3%REACTOME DATABASE ID RELEASE 66%10146200 PTK6 Activates STAT3 Socs3 Stat3 Stap2 Ptk6 CLEC7A INFLAMMASOME PATHWAY%REACTOME%R-RNO-5660668.1 CLEC7A inflammasome pathway Il1b Pycard Casp8 SIGNALING BY NTRK1 (TRKA)%REACTOME%R-RNO-187037.1 Signaling by NTRK1 (TRKA) Dusp3 Dusp4 Vrk3 Rps6ka2 Rps6ka1 Rps6ka3 Rps6ka5 LOC100912585 Dusp7 Dusp6 Atf1 Ap2a2 Irs2 Dnal4 Ralgds Kidins220 Sh3gl2 Irs1 Frs2 Kras Pik3r1 Pik3r2 Shc2 Cltc Clta Ntrk1 Ngf Ppp2cb Ppp2ca Ppp2r1a Ap2s1 Ap2a1 Ap2m1 Shc3 Mapk7 Crk Rap1a Ppp2r1b Mapkapk3 Mapkapk2 Mapk1 Pik3cb Rhoa Creb1 Crkl Hras Nras Sos1 Mapk14 Rapgef1 Mapk11 Shc1 LOC100911248 Grb2 PEPTIDE HORMONE METABOLISM%REACTOME%R-RNO-2980736.1 Peptide hormone metabolism Gh1 Ffar1 Pcsk1 Mboat4 Ghrl Lhb Igf1 Gip Ins1 Ins2 Tshb Bche Inhba Cga Slc30a5 Slc30a6 Slc30a8 Ache Pomc Ctsz Gnat3 Ctsd Gzmf Ace3 Dpp4 Lep Cpa3 Ctsg Grp Gpr119 Npepo Ffar4 Ero1l Gzmn Ero1lb Inha Exoc3 Inhbc Cma1 LOC100910060 Mme Exoc2 Exoc1 Exoc6 Exoc5 Exoc8 Exoc7 Cpb2 Cpb1 Ren Fshb Agt Ace LOC691670 Gnb3 Gng13 Atp6ap2 Sec11c Gcg MGC109340 Pla2g7 Spcs2 Sec11a CELL CYCLE%REACTOME DATABASE ID RELEASE 66%10144722 Cell Cycle Rfc1 Rfc2 Mdm2 Pole2 Kif23 Pole4 Mnat1 Rbx1 LOC100910252 Stag1 Pds5b Pias4 Pds5a Cdca5 Rad21 Smc1a Stag2 Smc3 Esco2 Esco1 Sumo1 Rpa3 Pole Pcna Brca1 Ccnh Blm Mdc1 Ube2v2 Ube2n Ruvbl1 Rfc5 Rfc4 Rfc3 Ube2d1 Tp53bp1 Rbl1 Cdk4 Akt1 E2f4 Hdac1 Herc2 Rpa1 Ccnd1 Rpa2 RGD1310212 Tfdp1 Tfdp2 Lig1 Kif20a Slc25a16 Fen1 Prkca Lyn Cul1 Ptk6 Ensa Arpp19 Psmb7 Psmb1 Dsn1 Psma5 LOC100911727 Cdk7 Pold2 Psma2 Pold1 Pold4 Psmd2 Psmc2 Psmd1 Psmd7 Psmd3 Psmd6 Rhno1 Bard1 Wrn Topbp1 Rbbp8 Rmi1 Rmi2 Rad50 Cep57 Rab8a LOC691918 Haus3 Prim2 Pola2 Ccne2 Ninl Ccne1 Prim1 Akap9 Ccp110 Mcm2 Atrip Mcm4 Mcm3 Cdk2 Mcm5 Clspn Mcm6 Mcm10 Rad1 Atr Mcm8 Mcm7 Rad17 Orc4 Orc5 Orc6 Orc1 Orc2 Setd8 Orc3 Cdc7 Rad9a Nbn Cdc6 Rad9b Cdc45 Mre11a Hus1 Ppp2cb Ppp2ca Skp1 Ppp2r1a Fbxw11 Ppp2r1b Btrc Mapk1 Akt3 Tinf2 Hist1h2bo Cnep1r1 Hist1h2bcl1 Rbl2 Hist2h3c2 Gorasp2 Hist1h2bk H3f3b Cks1l E2f5 Hdac1l Cables1 Numa1 Dyrk1a Lemd2 Cdkn2b Zfp385a Terf2ip Cenpw Nek6 Smarca5 Blzf1 Cdkn2c Hdac8 Cdk6 Cks1b Nek7 LOC100909949 Dctn1 Gmnn LOC100910200 Ccnd3 Whsc1 Cntrl Mcph1 H2afx Prdm9 Hist1h4b Dctn2 RGD1563307 Cep76 Mis18bp1 LOC684841 Rnf8 Hist1h2bh Acd Pcm1 Cep78 Rb1 LOC100912290 Ncapg Rbbp7 E2f2 Pot1b Hist1h2ail1 LOC686349 Hist1h4m LOC100911033 Lemd3 LOC102549173 Cep164 Mau2 LOC103690002 Dctn3 Tert Ofd1 Cep41 LOC100910152 Lmna Pot1 Vrk2 LOC100912338 Ncaph2 Hist1h3c Sdccag8 H2afb3 Lin37 Hist1h3f Vrk1 Ctdnep1 Prkar2b Lin52 Cenpj Hist2h4 Hjurp LOC684819 Lin54 Hist1h3a Plk4 Smc4 H2afj Hist2h2aa3 Tmpo Hist1h2bq Espl1 Hist2h2aa2 Smc2 Gins3 Gins4 LOC100364835 Gins1 LOC684762 Gins2 LOC100912076 Tubg2 Haus2 Haus1 Haus5 Alms1 Haus4 Terf1 Odf2 Terf2 Tubb4a Cdt1 Lmnb1 Lin9 Ncapg2 Ssna1 Tubg1 Cep63 Csnk1d Cep131 Tuba4a Cep250 Cep135 Csnk1e Cdk5rap2 Pcnt Hist1h2bg Cep72 LOC680097 Sfi1 Cep70 LOC684797 LOC100912418 Actr1a Hist1h2ba Nedd1 Hist3h2bb Cenpn Zwilch Cenpl Cenpo Dync1li2 Cenpt Cenpu Bub3 Bub1 Spdl1 Kntc1 Dync1i2 Mad1l1 Csnk2a2 Cenpk Cenph Cenpi Csnk2a1 Cenpf Cenpe Uimc1 Cenpm Ahctf1 Ndel1 Rcc2 LOC100909750 Pafah1b1 Ppp1r12a Mis12 LOC102555167 Dynll2 Ndc80 Cenpc Cenpa Dync1i1 Birc5 Rfwd2 Taok1 Nup88 Nup85 Anapc7 Cdc26 Cdc14a Cdc27 Cdc23 Pttg1 Ube2c Skp2 Cdkn1a Cdkn1b Anapc16 Cdc16 Nek2l1 Rae1 Anapc4 Anapc2 Anapc1 Lpin2 Lpin3 Lpin1 Nek2 Nup93 Nup98 Rab2a Nup107 Nup210 Anapc11 Nupl2 Anapc15 Aurka Anapc10 Nupl1 Fzr1 Fbxo5 Cdca8 Cdc25c Rangap1 Ppp1cb Ppp1cc LOC100909468 Aurkb Sec13 Xpo1 Rab1b Nup205 Rab1a LOC100911204 Spc24 Spc25 Abl1 Itgb3bp Sgol2 Ppp2r5e Incenp G6pc Nup155 Nsl1 B9d2 Cdc20 Kif2a Kif2c Kif2b Bub1b Kif18a Ppp2r5c Ppp2r5a Ppp2r5b Zwint Mad2l1 Casc5 Nup153 Clasp2 Ercc6l Nuf2 Tpr Clasp1 LOC679582 Mapre1 Cdc42 Pmf1 Nup54 Ckap5 Pom121 Ska2 Nup62 Sgol1 Zw10 Ska1 Psmc6 Nup43 Psmb10 Nup133 Psmb8 Psmb9 Psmb4 Aaas Psmb11 Psmb5 Psmf1 Psmb6 Bre Psmd4 Psmb2 Psmd5 Psmd8 Npap60 Psmd9 Psmb3 Nup35 Psma8 Brcc3 Nup37 Psmd11 Psmd12 Ccna2 Ccna1 Psmd13 Psmd14 Phf20 Atm Psmc3 Ajuba Ranbp2 Src Hsp90ab1 Babam1 Tubb5 Ywhah Ywhag Prkcb Sfn Ywhaz Ywhab Ywhaq Ywhae Prkaca Ppp2r3b Bora Fbxl18 Fkbpl Fbxl7 Ppme1 Foxm1 Lcmt1 Tubgcp2 Dync1h1 Dync1li1 LOC103692716 Akt2 Gorasp1 Csnk2b Fam175a E2f1 E2f3 Tpx2 Cdk11b LOC100910954 Cdk1 Mdm4 Chek2 Gtse1 Psmc5 Psma1 Phlda1 Psma4 Cdc25b Cdc25a Psmc1 Psma3 Wee1 Pkmyt1 Psmc4 Psma6 Ppp2r2a Psme1 Nme7 Tubgcp5 Psme2 Tubgcp6 Tubgcp3 Tubgcp4 Optn LOC100909844 LOC100363782 Mzt1 Mzt2b TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G1 CELL CYCLE ARREST%REACTOME%R-RNO-6804116.1 TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest Cdk2 E2f7 E2f8 Ccna2 Cdkn1a Ccna1 Cdkn1b Ccne2 Ccne1 INTERLEUKIN-2 SIGNALING%REACTOME%R-RNO-9020558.1 Interleukin-2 signaling Stat5a Jak3 Il2rg Il2 Ptk2b Jak1 Il2ra Shc1 Syk Il2rb DEPURINATION%REACTOME DATABASE ID RELEASE 66%10144975 Depurination Mpg Ogg1 Mutyh G2 M DNA REPLICATION CHECKPOINT%REACTOME%R-RNO-69478.1 G2 M DNA replication checkpoint Wee1 Pkmyt1 Cdk1 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX%REACTOME DATABASE ID RELEASE 66%10145392 Formation of the beta-catenin:TCF transactivating complex Leo1 Hist1h2bo Hist1h2bcl1 Hist2h3c2 Hist1h2bk H3f3b Smarca4 Hdac1l Tle3 Crebbp Rbbp5 Cdc73 LOC100910200 H2afx Hist1h4b LOC684841 Hist1h2bh LOC100912290 Hist1h2ail1 Hist1h4m LOC102549173 Tert LOC103690002 LOC100910152 Men1 LOC100912338 Hdac1 Hist1h3c H2afb3 Hist1h3f Hist2h4 LOC684819 Hist1h3a H2afj Hist2h2aa3 Hist1h2bq Hist2h2aa2 Ash2l LOC100364835 LOC684762 Pygo2 Tcf7 Hist1h2bg Lef1 LOC680097 Tcf7l1 Bcl9l LOC684797 LOC100912418 Tle4 Hist1h2ba Tle1 Hist3h2bb Tle2 Pygo1 ACTIVATION OF THE TFAP2 (AP-2) FAMILY OF TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 66%10146233 Activation of the TFAP2 (AP-2) family of transcription factors Cited1 Cited4 Yeats4 Tfap2b Tfap2c Crebbp Cited2 Tfap2a Tfap2d Tfap2e ATF6 (ATF6-ALPHA) ACTIVATES CHAPERONES%REACTOME%R-RNO-381033.1 ATF6 (ATF6-alpha) activates chaperones Mbtps1 Mbtps2 Atf6 SHC-MEDIATED CASCADE:FGFR2%REACTOME%R-RNO-5654699.1 SHC-mediated cascade:FGFR2 Kras Fgf16 Fgf17 Fgf10 Fgf9 Fgfr2 Fgf7 Fgf2 Fgf8 Fgf23 Fgf22 Fgf4 Fgf1 Fgf3 Fgf6 Fgf5 Hras Nras Sos1 Shc1 Fgf20 Grb2 G1 PHASE%REACTOME%R-RNO-69236.1 G1 Phase Ccnd3 Src Ppp2r3b Rb1 E2f2 Rbl1 Cdk4 Mnat1 Cul1 Ptk6 E2f4 Ppp2cb Ppp2ca Ccnd1 Skp1 Ppp2r1a Tfdp1 Tfdp2 Rbl2 LOC100909750 E2f1 E2f3 Cks1l Skp2 Cdkn1a Cdk7 Cdkn1b Ppp2r1b E2f5 Ccnh Cdkn2b Ppp2r2a Lyn Cdkn2c Cdk6 Cks1b Abl1 SYNTHESIS OF CL%REACTOME DATABASE ID RELEASE 66%10145873 Synthesis of CL Crls1 SIGNALING BY PDGF%REACTOME DATABASE ID RELEASE 66%10145268 Signaling by PDGF Stat5a Src Kras Grb7 Stat1 Pdgfra Pik3r1 Pdgfrb Pik3r2 Stat3 Nck1 Pdgfa Pdgfb Furin Col9a1 Col9a2 Stat6 Col9a3 Crk Col4a1 Bcar1 Thbs2 Pik3cb Thbs1 Ptpn11 Pdgfc Col4a2 Pdgfd Plg Thbs4 Plat Plcg1 Hras Crkl Nras Sos1 Rasa1 Ptpn12 Rapgef1 Nck2 Spp1 Grb2 LOC100911248 SIGNALING BY FGFR%REACTOME DATABASE ID RELEASE 66%10145253 Signaling by FGFR Frs3 RGD1565904 Fgf23 Fgf22 Polr2g Fgf4 Polr2h Fgf1 Polr2e Fgf3 Polr2f Fgf6 Polr2j Fgf5 Polr2k Polr2d Polr2i Polr2b Polr2c Polr2a Fgf20 Gab1 Mknk1 LOC100912534 Esrp2 Gtf2f1 Esrp1 Gtf2f2 Fgf16 Rbfox2 Fgf17 Fgfrl1 Tia1 Fgf10 Tial1 Fgfbp3 Fgf9 Fgfbp1 Fgfr2 Fgf7 Fgf2 Spry2 Fgf8 Cbl Fgfr3 Fgfr1 Fgfr4 Fgf19 Frs2 Kras Src Pik3r1 Hnrnph1 Ppp2cb Ppp2ca Ppp2r1a LOC100911822 Flrt1 Flrt2 Ncbp2 Ncbp1 Mapk1 Spred1 Ptpn11 Spred2 Plcg1 Hras Nras Hnrnpm Hnrnpf Sos1 Shc1 Galnt3 Grb2 FRS-MEDIATED FGFR3 SIGNALING%REACTOME%R-RNO-5654706.1 FRS-mediated FGFR3 signaling Kras Frs3 Fgf23 Fgf22 Fgf4 Fgf1 Fgf3 Fgf6 Fgf5 Fgf20 Fgf16 Fgf17 Fgf10 Fgf9 Fgfr2 Fgf7 Fgf2 Fgf8 Fgfr3 Fgfr1 Fgfr4 Ptpn11 Fgf19 Hras Nras Sos1 Frs2 Grb2 ACTIVATION OF DNA FRAGMENTATION FACTOR%REACTOME DATABASE ID RELEASE 66%10145439 Activation of DNA fragmentation factor Dffa Kpna1 Kpnb1 LOC100911856 Casp3 Hmgb2 RGD1559962 CASPASE ACTIVATION VIA EXTRINSIC APOPTOTIC SIGNALLING PATHWAY%REACTOME%R-RNO-5357769.1 Caspase activation via extrinsic apoptotic signalling pathway Faslg Appl1 Cflar Fadd Dcc Traf2 Casp3 Ripk1 Tradd Tnfsf10 Casp8 Casp9 Fas INTERLEUKIN-21 SIGNALING%REACTOME%R-RNO-9020958.1 Interleukin-21 signaling Stat5a Jak3 Il21r Il2rg Stat1 Il21 Jak1 Stat3 BETA-CATENIN INDEPENDENT WNT SIGNALING%REACTOME DATABASE ID RELEASE 66%10145579 Beta-catenin independent WNT signaling Plcb1 Psmc6 Psmb10 Psmb8 Psmb9 Psmb4 Psmb11 Pde6b Nlk Plcb3 Psmb5 Psmf1 Psmb6 Pde6a Psmd4 Rac1 Psmb2 Psmd5 Psmd8 Psmd9 Psmb3 Psma8 Psmd11 Psmd12 Psmd13 Psmd14 Ap2a2 LOC100361515 Psmc3 Daam1 Pde6g Pard6a Wnt5b Wnt5a Prickle1 Fzd1 Cltc Cltb Fzd3 Clta Fzd2 Gnao1 Fzd4 Fzd7 Fzd6 Prkcb Ap2s1 Ppp3r1 Wnt1 Wnt11 Wnt4 Gnat2 Ap2a1 Ror1 Ror2 Ap2m1 Gnb3 Gnb5 Gnb2 Gnb1 Gng13 Gng12 Gng11 Prkca LOC100912034 Gnb4 Gng4 Gngt2 Gng5 Gngt1 Gng8 Gng3 Camk2a Map3k7 Smurf1 LOC100910771 Rac2 Gng10 G6pc Psmb7 Psmb1 Psma5 Dvl1 Psma2 RGD1560225 Psmc5 Psma1 Psmd2 Ppp3ca Psma4 Dvl2 Psmc1 Dvl3 Arrb2 Rhoa Psma3 Pfn1 Psmc4 Psma6 Psmc2 Psme1 Psmd1 Lef1 Psme2 Psmd7 Psmd3 Psmd6 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS%REACTOME%R-RNO-73817.1 Purine ribonucleoside monophosphate biosynthesis Impdh1 Impdh2 Pfas Ppat LOC100912917 Adss Gmps Lhpp Atic Gart Adsl Adssl1 Paics GRB7 EVENTS IN ERBB2 SIGNALING%REACTOME%R-RNO-1306955.1 GRB7 events in ERBB2 signaling Nrg1 Grb7 LOC102552659 Erbb3 Erbb2 Nrg2 DEFENSINS%REACTOME%R-RNO-1461973.1 Defensins Defb26 Defb28 Ccr6 Defb30 Defb18 Defb36 RatNP-3b Defb14 Defb12 Defb29 Defb49 Defb25 Tlr10 Defb43 Defb44 Cd4 Art1 Defb13 Defb41 Defb1 Defb22 Defb23 Defb20 Defb21 Np4 Defa7 Defa11 Defa5 Defa10 Tlr2 RUNX2 REGULATES BONE DEVELOPMENT%REACTOME DATABASE ID RELEASE 66%10146257 RUNX2 regulates bone development Runx2 Rbm14 LOC100911677 PROPIONYL-COA CATABOLISM%REACTOME DATABASE ID RELEASE 66%10144800 Propionyl-CoA catabolism Pccb Mcee Mmaa Mut KANDUTSCH-RUSSELL PATHWAY%REACTOME DATABASE ID RELEASE 66%10146182 Kandutsch-Russell pathway Ebp Dhcr7 Sc5d Dhcr24 COMPLEMENT CASCADE%REACTOME%R-RNO-166658.1 Complement cascade C1s Elane C1r Masp2 C1qb Colec10 C4a C1qa C4b LOC100909666 Gzmm LOC102549354 C2 Vtn C5ar1 Cd59 Cpn1 Cpn2 Cr2 Cpb2 Clu C5ar2 Cd46 Cfd Serping1 Colec11 C6 Cfhr1 Cd19 C8g C3 RGD1564614 Cd81 C8a C8b Cfh F2 C3ar1 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 66%10145155 MyD88 cascade initiated on plasma membrane Map2k7 Ripk2 Map2k6 Ager Dusp3 Map2k4 Map3k8 Dusp4 Peli3 Nfkbib LOC100912399 Peli2 Map3k1 Traf6 Cul1 Vrk3 Rps6ka2 Rps6ka1 App Rps6ka3 Rps6ka5 LOC100912585 Tab1 Dusp7 Dusp6 Rela Atf1 Atf2 Map3k7 Peli1 Irak2 Nfkbia LOC100910771 Ube2n Jun Ppp2cb Ppp2ca Skp1 Ppp2r1a Nfkb2 Nfkb1 Mapk9 Mapk8 Fos S100b Mapk7 Dhx9 Fbxw11 Chuk Ppp2r1b Ecsit Mapkapk3 Btrc Mapkapk2 Mapk1 Nkiras1 LOC100362142 Nod1 Nod2 Nkiras2 Creb1 Tab2 Tab3 LOC100912618 Ube2v1 Ikbkb Mapk14 Myd88 Tnip2 Mapk11 Mapk10 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS%REACTOME%R-RNO-141405.1 Inhibition of the proteolytic activity of APC C required for the onset of anaphase by mitotic spindle checkpoint components Anapc7 Cdc26 Cdc27 Cdc23 Ube2c Bub3 Ube2d1 Anapc16 Cdc16 Cdc20 Anapc4 Anapc2 Anapc1 Bub1b Anapc11 Anapc15 Mad2l1 Anapc10 INTESTINAL HEXOSE ABSORPTION%REACTOME%R-RNO-8981373.1 Intestinal hexose absorption Slc2a5 Slc2a2 Slc5a1 DOPAMINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME%R-RNO-212676.1 Dopamine Neurotransmitter Release Cycle Rab3a Rims1 Lin7c Cplx1 Stx1a Lin7a Syn3 Syt1 Syn2 Vamp2 Stxbp1 Ppfia1 Ppfia2 Ppfia3 Ppfia4 Bzrap1 Syn1 Apba1 Lin7b MET ACTIVATES RAS SIGNALING%REACTOME DATABASE ID RELEASE 66%10146212 MET activates RAS signaling Hgf Kras Muc20 Hras Nras Sos1 Ranbp10 Ranbp9 Shc1 Grb2 DAP12 SIGNALING%REACTOME DATABASE ID RELEASE 66%10145432 DAP12 signaling Kras Fyn Pik3r1 Vav3 Pik3r2 B2m Klrc2 Rac1 Pik3cb Trem2 Lat Plcg1 Tyrobp Hras Vav2 Nras Sos1 Lcp2 Shc1 Syk Grb2 GAB1 SIGNALOSOME%REACTOME DATABASE ID RELEASE 66%10145248 GAB1 signalosome Gab1 Ptpn11 Src Csk Pik3r1 Pxn Egfr Grb2 RIPK1-MEDIATED REGULATED NECROSIS%REACTOME%R-RNO-5213460.1 RIPK1-mediated regulated necrosis Faslg Cflar Fadd Birc3 Birc2 Mlkl Ripk3 Traf2 Ripk1 Tradd Xiap Tnfsf10 Casp8 Fas REGULATION OF PTEN GENE TRANSCRIPTION%REACTOME%R-RNO-8943724.1 Regulation of PTEN gene transcription Eed Rbbp7 Mecom Hdac1 Lamtor3 RragB Phc1 Phc2 Sall4 Mtor Scmh1 Cbx4 Cbx2 Rheb Lamtor2 Cbx8 Lamtor1 Cbx6 Rptor Lamtor4 Bmi1 Hdac2 Rnf2 Lamtor5 Mbd3 Mlst8 Ring1 Hdac1l Chd3 Chd4 Rraga Phc3 Rragc Rragd Slc38a9 Mta3 Ezh2 Mta1 Mta2 Gatad2a Maf1 Gatad2b AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1%REACTOME DATABASE ID RELEASE 66%10145450 Autodegradation of the E3 ubiquitin ligase COP1 Psmc6 Psmb10 G6pc Psmb8 Psmb9 Psmb4 Psmb11 Psmb5 Psmf1 Psmb6 Psmd4 Psmb2 Psmd5 Psmd8 Psmb7 Psmd9 Psmb1 Psmb3 Psma8 Psmd11 Psmd12 Psmd13 Psmd14 Atm Psma5 LOC100910954 Psma2 Psmc3 Psmc5 Psmd2 Psma1 Psma4 Psmc1 Psma3 Psmc4 Psmc2 Psma6 Psme1 Psmd1 Psme2 Psmd7 Psmd3 Rfwd2 Psmd6 GENE EXPRESSION (TRANSCRIPTION)%REACTOME DATABASE ID RELEASE 66%10144751 Gene expression (Transcription) Thoc5 Rfc2 Thoc7 Thoc3 Gtf2h1 Thoc2 Gtf2h2 Bdp1 Usp7 Thoc1 Nrbf2 Zfp28-ps1 Zfp445 Myo1c Banp Zfhx3 Rarg Esr2 Mnat1 Thoc6 Rbx1 RGD1565904 Nr2c2ap Ice2 Hnf4a Zc3h8 Polr2g Hnf4g Polr2h Zfp473 Polr2e Nr4a3 Polr2f Nr4a1 Polr2j Nr4a2 Polr2k LOC685619 Polr2d Zfp212 Polr2i Zfp418 Polr2b Ddx39a Polr2c Zfp213 Ddx39b Polr2a Zfp867 Actl6a Ice1 Chtop Esrra Esrrb LOC100912534 Triap1 Actb Elf1 Sumo1 Ell Elf2 Rpa3 Tp53bp2 Nr6a1 Nr2c2 Nr2c1 Atp5c1 Iws1 Tcea1 Zkscan1 Pcna Zfp263 Zfp266 Taf7l Zfp496 Ccnh LOC102555919 Mapkapk5 Rara Rarb Yap1 Zfp498 Tead2 Pidd1 Tead1 Nr2e1 Ube2i Zfp483 Nr2f6 Gtf2h3 Rfc5 Nr2f1 Rfc4 Zfp287 Rfc3 LOC691135 Nr2e3 Gtf2h5 Zfp282 Gtf2h4 Zfp786 Aff4 Actl6b Zfp770 Smarce1 Zfp771 Zfp354c Pbrm1 Gtf2e1 Tceb3 Arid1b Zfp354a Arid1a Zfp791 Polr3d Gtf2e2 Zfpm1 Polr3c Cdk4 Polr3a Akt1 Polr3e Polr3b Supt6h Smarcd1 LOC102554302 Ercc3 Polr3h Smarcd2 Ercc6 Polr3k Smarcd3 Brpf3 Nuak1 Rpa1 Foxp3 Ccnd1 Polr3g Rpa2 Brpf1 Polr3f LOC100363472 LOC100911822 Brd1 Taf7 Nr1i3 Cpsf3l Ercc2 Taf3 Taf6 Kat6a Taf5 Ing5 Taf8 Zfp202 Tp53inp1 Zfp839 Zfp420 LOC100911519 Tbx5 Rxrg Runx2 Tp63 Nrbp1 Yaf2 Zfp426 LOC102553866 Fyttd1 Nelfe Nelfa Nelfb Gtf2b Znf740 Cradd Bnip3l Gtf3a Asun Slc25a16 RGD1562299 Znf750 Ssrp1 Mbd2 L3mbtl1 L3mbtl2 Zfp775 Zfp777 Dek LOC361990 Ints4 Ints5 Map2k6 Ints6 Ints7 Ints9 Zfp746 Phax Zfp583 Ints1 Ints3 Ints2 Zfp180 Zfp189 Dyrk2 Cul1 Epc1 Zfp804b Zfp703 Tp53rk LOC100911224 Zfp707 Zfp710 Supt16h Tnrc6b Zfp711 Mterf Tnrc6a Tnrc6c Krba1 Ssu72 Zfp566 Zfp169 Zfp167 Vwa9 Zfp383 Rrn3 Zfp37 Zfp113 Zfp110 Zfp382 Zfp112 Zfp46 Zfp398 Zfp111 Trim28 Zfp394 Zfp2 Sarnp Zfp317 Zfp597 Zfp74 LOC501406 Zfp9 Zfp1 Zfp84 Nabp1 Nabp2 Rslcan18 Serpinb13 Slu7 Zfp90 Zim1 Zfp641 Zfp647 LOC102549842 LOC102555083 LOC102546354 Auts2 Pax5 LOC102553962 Mga Zfp668 Snapc3 Snapc4 Mybbp1a Lsm10 Lsm11 Zfp667 Prelid1 Psmb7 Taf11 Psmb1 LOC679894 Taf15 Zfp248 Esrrg Taf13 Taf12 Mllt1 Rrp8 Taf4b Rpap2 Nr0b1 Ddx21 Noc2l Nr0b2 Gtf3c6 Gtf3c5 Gtf3c1 Poldip3 Max Psma5 Gtf3c3 Parp1 Gtf3c4 Supt4h1 Pou4f2 Cdk7 Zfp286a Hipk1 Polr3gl E2f6 Zfp324 Brf1 Psma2 Brf2 Slbp Brd2 Psmd2 Zfp697 Zfp612 Zfp692 Zfp691 Snapc5 Psmc2 Snapc2 Ppp1r13b LOC100910137 Psmd1 Ppp1r13l Psmd7 Zfp606 Ttc5 Zfp688 Rorb Psmd3 LOC100910121 Psmd6 Snrpf Wdr33 Gata2 LOC100911167 Tal1 Ldb1 Tp73 Gata1 Lmo2 Lmo1 Atrip Cdk2 Rad1 Atr Rad17 Setd8 Rad9a Suv39h1l1 Rad9b Rbbp5 Srsf3 Upf3b U2af2 Papola Srsf6 Hus1 Srsf7 Srsf4 Srsf5 Tfap2a Srsf2 Ppp2cb Ppp2ca Skp1 Srsf9 Ppp2r1a Dhx38 Clp1 Magoh Phc1 Phc2 Ncbp2 Srsf1 Ncbp1 Tfap2b Tfap2c Ppp2r1b Cstf2t Eif4a3 Sympk Tfap2d Tfap2e LOC100910660 Srrm1 Mapk14 Cdc40 Mapk11 Snrpb Rxra Pparg Prmt5 Prmt6 Hist1h2bo Hist1h2bcl1 Scmh1 Cbx4 Hist2h3c2 Cbx2 Hist1h2bk Cbx8 H3f3b Cbx6 Bmi1 Hdac2 Rnf2 Mbd3 Ring1 Smarca4 Chd3 Smarca2 Chd4 LOC100911617 Phc3 Arid2 Smarcc1 Smarcc2 Mta3 Smarcb1 Mta1 Mta2 Gatad2a Gatad2b Meaf6 LOC100909949 Eed LOC100910200 H2afx Hist1h4b Wdr5 Phf19 Kmt2a LOC684841 Smyd2 Hist1h2bh Dnmt1 LOC100912290 Rbbp7 Hist1h2ail1 Hist1h4m LOC102549173 Ehmt2 LOC103690002 LOC100910152 Ehmt1 Dnmt3a LOC100912338 Hist1h3c H2afb3 Hist1h3f Dnmt3b Hist2h4 LOC684819 Hist1h3a H2afj Hist2h2aa3 Suv39h1 Hist1h2bq Hist2h2aa2 Mtf2 Ash2l Phf1 LOC100364835 Dpy30 LOC684762 Jarid2 Hist1h2bg Ezh2 LOC680097 LOC684797 LOC100912418 Hist1h2ba Hist3h2bb Aebp2 Paf1 Rtf1 Supt5h Rnmt Rngtt Skp2 Cdkn1a Cdkn1b Chm Gadd45a Bax Rnps1 Magohb Rbm8a Pcf11 Fip1l1 Rabggta Nudt21 Snrpd3 Aurka Cstf2 U2af1l4 Cpsf7 Cpsf2 Cpsf3 Cpsf4 Cstf1 Cpsf1 Rabggtb Sf3b1 Psmd11 Psmd12 Ccna2 Ctr9 Ccna1 Rffl Psmd13 Ccng1 Psmd14 Phf20 Atm Rictor Wdr61 Tceb2 Tceb1 Psmc3 Src Ywhah Ywhag Sfn Ywhaz Ywhab Ywhaq Ywhae Med1 Lamtor3 Tdg Cited1 Nr5a2 Gtf2f1 Gtf2f2 Lamtor2 Lamtor1 Gtf2a1 Bmyc Prmt1 Esr1 Pou2f1 Cbfb Gata3 Crebbp Pgr Tbp Runx1 Notch1 Kras Cdk13 Prkra Ago3 Dicer1 Csnk2b Usp2 Tsnax Ago4 Ago2 Daxx LOC100910954 Cdk1 Mdm4 Tsn Chek2 Tarbp2 Taf10 Rnf34 Mapkap1 Sgk1 Ptpn11 Notch2 Taf9b Mdm2 Notch3 Cdk5 RGD1308751 Leo1 Pml Cited2 Brca1 Blm Pcgf2 Hdac4 Ppm1d Rbm14 LOC100911677 Sox9 Thra Thrb Smad3 Ing2 Ccnt2 Smad2 Nr1h3 Nr1h2 Usp9x Sp1 Ube2d1 Skil Rbl1 Ncor2 Nr5a1 Cdk9 Rora Nr1i2 E2f4 Hdac1 Tgif2 Tgif1 LOC100911274 Atp1b4 Trim33 Ccnk Ube2d3 Wwtr1 Tfdp1 Tfdp2 Stub1 MGC114246 Testin LOC100364523 Cdk5r1 Ctsl Ctsm Ctsj RGD1564657 Ctsk Ctsq Ctsr Cts8 Cts7 RGD1564827 Rhno1 Bard1 Wrn Topbp1 Rbbp8 Rmi1 Rmi2 Rad50 Lhb LOC364561 Pin1 Brd7 Sesn2 Plk2 Txnrd1 Ccne2 Sesn1 Plk3 RragB Ccne1 Prkab1 Sesn3 Prkab2 Gsr Cts8l1 E2f7 E2f8 Btg2 Cnot6l Cnot11 Tgfb1 Tmem55b Pip4k2b Nbn Cga Pip4k2c Mre11a Tnks1bp1 Cnot8 Rqcd1 Cnot3 Cnot1 Cnot2 Cnot7 Cnot4 Mtor Prdx1 Ddit4 Rheb Prkag3 Rptor Lamtor4 LOC502894 Tsc1 Lamtor5 Txn1 Sin3a Mlst8 Sin3b Prkaa1 Tsc2 Rraga Prkaa2 Rragc Akt3 Rragd Slc38a9 Smurf1 E2f5 Hdac1l Snw1 Zfp385a Smarca5 Cdk6 Cdc73 Atad2 Ccnd3 Cenpj Cited4 Yeats4 Tcf7 Lef1 Tcf7l1 Nr1h4 Maml1 Rbpj Kat2a Rbpjl2 Csnk2a2 Csnk2a1 LOC100909750 Vdr Nup88 Hipk2 Nup85 Rae1 Nup93 Nup98 Nup107 RGD1306195 Nup210 Ubtf Polr1b Taf1d Taf1c Cd3eap Znrd1 Ppara Polr1c Polr1a Nupl2 Ppard Nupl1 Ptrf Ttf1 Cdc25c Aurkb Nup205 Abl1 G6pc Nup155 Men1 Polrmt Ppp2r5c Tfam Gpi Tfb2m Nup153 Tpr Twistnb Pdpk1 Polr1e Nup54 Pom121 Nup62 Psmc6 Psmb10 Nup43 Nup133 Psmb8 Psmb9 Psmb4 Psmb11 Aaas Psmb5 Psmf1 Psmb6 Psmd4 Psmb2 Psmd5 Npap60 Psmd8 Psmd9 Psmb3 Nup35 Psma8 Nup37 Ranbp2 Akt2 Nr1d1 Pcgf6 Rprd1a Nr1d2 Pcgf5 Notch4 Cdk12 Eaf1 Eaf2 Taf2 Zfp14 Slmo1 Taf9 RGD1562871 Ell3 Zfp12 Ell2 Casp2 Zfp13 Rprd1b Zfp28 Baz1b Zfp18 Tpx2 Psmc5 Psma1 Psma4 Psmc1 Psma3 Psmc4 Psma6 Psme1 Psme2 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES%REACTOME%R-RNO-450282.1 MAPK targets Nuclear events mediated by MAP kinases Dusp3 Dusp4 Vrk3 Rps6ka2 Rps6ka1 Jun Rps6ka3 Rps6ka5 Ppp2cb Ppp2ca LOC100912585 Ppp2r1a Dusp7 Dusp6 Atf1 Atf2 Mapk9 Mapk8 Fos Mapk7 Ppp2r1b Mapkapk2 Mapk1 Creb1 Mapk14 Mapk11 Mapk10 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER%REACTOME%R-RNO-76071.1 RNA Polymerase III Transcription Initiation From Type 3 Promoter Bdp1 Polr3d Snapc3 Snapc4 Polr3c Polr3a Polr3e RGD1565904 Polr3b Polr3h Polr2h Polr3k Polr2e Polr2f Polr3g Polr1c Polr3f Polr2k LOC100912534 Polr3gl Brf2 Pou2f1 Snapc5 Snapc2 Tbp HSF1-DEPENDENT TRANSACTIVATION%REACTOME%R-RNO-3371571.1 HSF1-dependent transactivation Mtor Camk2g Hsbp1 Dnajb1 Cryab Rptor Hsf1 Hspb8 Hspa1l Akt1s1 Hsp90ab1 Hspa2 LOC103692716 Ptges3 Mlst8 Camk2d Camk2a Ptges3l1 Fkbp4 Crebbp DOWNSTREAM TCR SIGNALING%REACTOME DATABASE ID RELEASE 66%10145375 Downstream TCR signaling Psmc6 Pten Psmb10 Psmb8 Psmb9 Psmb4 Psmb11 Psmb5 Psmf1 Psmb6 Psmd4 Traf6 Psmb2 Cul1 Psmd5 Psmd8 Psmd9 Psmb3 Psma8 Psmd11 Cdc34 Psmd12 Cd4 Psmd13 Rela Psmd14 Map3k7 Prkcq Psmc3 Nfkbia LOC100910771 Ube2n Bcl10 G6pc Pik3r1 Pik3r2 Ube2d1 Psmb7 Inpp5d Psmb1 Cd3e RT1-Ba RT1-Bb Skp1 RT1-Da RT1-Db2 RT1-Db1 LOC688090 Nfkb1 Cd247 Psma5 Fbxw11 Chuk Btrc Pdpk1 Psma2 Psmc5 Pik3cb Cd3g Psma1 Psmd2 LOC100362142 Psma4 Psmc1 Cd3d Psma3 Psmc4 Psmc2 Tab2 Psma6 Psme1 LOC100912618 Ube2v1 Psmd1 Psme2 Ikbkb Psmd7 Psmd3 Psmd6 P75NTR RECRUITS SIGNALLING COMPLEXES%REACTOME%R-RNO-209543.1 p75NTR recruits signalling complexes Ripk2 Prkci Sqstm1 Ngf Ngfr Ikbkb Myd88 Traf6 CHOLESTEROL BIOSYNTHESIS%REACTOME%R-RNO-191273.1 Cholesterol biosynthesis Ppapdc2 Msmo1 Arv1 Sqle Hmgcs1 Dhcr7 Acat2 Ggps1 RGD1564347 Sc5d Tm7sf2 Cyp51 Nsdhl Mvd Hmgcr Ebp Pmvk Dhcr24 RGD1562948 Fdft1 MEMBRANE TRAFFICKING%REACTOME DATABASE ID RELEASE 66%10145299 Membrane Trafficking Kif21a Kif21b Kifc1 Kif3c Racgap1 Kif22 Kif3b Kif23 Kif18b Kifap3 Kif11 Egfr Kif12 Kif4a Kif6 Kif1a Kif1c Dnm2 Kif27 Kif9 Kif13b Cops8 Cops2 Nedd8 Akt1 Cops4 Cops6 Myo6 Cops3 Kif20b Kif16b Kif26a Kif20a Kif26b Kif19 Galnt1 Galnt2 App Cd59 Arf6 Rab3ip Vamp8 Gdi2 Sar1b Stam2 Sh3gl2 Apob Sh3gl1 Sh3kbp1 Sh3gl3 Stam Rab4a Ank1 Ctsc Ctsz Itsn1 Spta1 Dnm1 Dnm3 Sptbn1 Cops7b Cops7a Snap29 Pla2g6 Rab8a Tgfa Alpp Alpi Kif3a Col7a1 F8 Scfd1 Tsc1 Tsc2 Akt3 Pik3c2a Bnip1 Rabgap1 Madd Rin3 Clvs1 Snx18 Chmp2b Chmp2a Use1 Rgp1 Hip1r Pla2g4a LOC100909679 Ulk1 Sbf2 Ap1m2 Mvb12b Mvb12a Snx5 Stx16 Snx9 Fnbp1l Snx2 Chmp4b Stx18 Chmp4c Golga5 Gapvd1 Golga1 Golga4 Dennd3 Acbd3 Sort1 Dnase2 Tbc1d10a Clint1 Tsg101 Tbc1d10b Cbl Yipf6 Ap4s1 Vta1 Hip1 Hps4 Tpd52 LOC100910792 Hps1 Mon1b Mon1a Cyth1 Cyth4 Cyth3 Cyth2 Trip11 Dennd1a Nbas Trappc12 Trappc11 Dennd1b Dctn1 Dctn2 Dctn3 Rab11a Csnk1d Arrb1 Arrb2 Adrbk1 Actr1a Klc1 Sec24a Dync1li2 Sec24b Copa Sec24d Sbf1 Dync1i2 Gja10 Gjd2 Syt1 Vamp2 Man1c1 Gjc1 Klc4 Man1a1 Cenpe Klc2 Klc3 Chmp4bl1 Cog4 Cttn Cog6 Gcc1 Cog8 Amph Cog3 Gja5 Rhobtb3 Pafah1b1 Cpd Cog1 Gja3 Cog2 Gja8 Usp6nl Gja4 Sec23ip Rala LOC100361515 Lman1l Gjb6 Scoc Cog7 Ap1b1 LOC102555167 Gjb2 Stx6 Dynll2 Vps37a Gjb3 Gjb4 Rab39a Vps37d Vps37c Stx4 Dync1i1 Rab11b Vps37b Gjc2 Tbc1d1 Tbc1d2 Ykt6 Tbc1d7 Sec24c Rabepk Gabarap Vps45 Bin1 Tmed7 Ubap1 Tmed3 Vps53 Vps52 Tmed2 Cux1 Ap4e1 Gjd4 Arfip2 Vps54 Rab6b Rab9a Ap4b1 Napg Ap1g2 Napb Ric1 Synj1 Napa Fnbp1 Vps4b Ccz1b Tpd52l1 St5 Snapin Rab3gap2 Tmed9 Dennd6b Dennd6a Ap3b1 Bicd2 Synj2 Vps25 Nsf Bicd1 Chmp5 Alppl2 Chmp7 Golim4 Bloc1s3 Snf8 Vps36 Chmp6 Rab8b Chmp3 Pum1 Arl1 Dennd5a Ap4m1 Bloc1s4 Gabarapl2 Agpat3 Bloc1s1 Bloc1s6 Rab3il1 LOC100910929 Chm Arfrp1 Trappc8 Dennd4a Dennd4b Arcn1 Pacsin2 Rab7b Pacsin3 Tbc1d13 Tbc1d16 Tbc1d15 Tbc1d17 Sytl1 Dennd2a Dennd2d Rab33a Dennd2c Rab33b Trappc13 Ap1s3 Ap1s1 Plin3 Ap1s2 Tbc1d25 Gak Pafah1b3 Tbc1d14 Trappc10 Rab35 Rab36 Ppp6c Trappc2l Rab43 Pip5k1c Rab21 Trappc6a Trappc6b Rab12 Rab13 Ankrd28 Rab32 Sec13 Rab30 Rab38 Rab1b Wasl Rab1a Tmem115 Ocrl Arfgap2 Arpc4 Golgb1 Arpc3 Arfgap3 Kif2a Arfgap1 Kif2c Kif2b Kif18a Mcfd2 Preb Capzb Kif5b Kif5a Actr3 Sec31a Stx17 Dvl2 Gosr2 Gosr1 Zw10 Tmed10 Areg Stx5 Ftl1 Bet1 Arf5 Cnih1 Igf2r Arf4 Ctage5 Rab27a Gbf1 Cnih3 Cnih2 Ap2a2 Man2a1 Man2a2 Copz2 Copz1 Lman2 Sec16a Sec16b Lman1 Trappc2 Gja1 Trappc5 Src Rab27b RGD1561661 Rab3a Copb1 Wnt5a Cltc Rab7a Cltb Tfg Clta Fzd4 Ywhah Ywhag Sfn Ap2s1 Ywhaz Ywhab Ap2a1 Ywhaq Ywhae Trappc3 Ap2m1 LOC100910318 Rab5b Kdelr1 Rab5c Tbc1d20 Capza2 Capza3 Rab6a Kdelr2 Gjb1 Rab9b Ppp6r3 Ppp6r1 Trappc1 Kdelr3 Agtr1b Agtr1a Syt11 Aak1 Sgip1 Eps15l1 LOC100909548 Itsn2 Scarb2 LOC100910557 Necap1 Agfg1 Snap91 Ubqln2 Sptan1 Picalm Tgoln2 Ldlr Rab18 Tor1a Ston2 Tfrc RGD1307443 Rab10 Tf Rab14 Chrm2 Necap2 Cd4 Actr10 Tor1b Avp Dab2 Ston1 Dync1h1 Dync1li1 Copg1 Dctn5 Dctn6 Ins1 Ins2 Dctn4 Folr1 Akt2 Uso1 Gorasp1 Ap1m1 LOC100360087 Txndc5 Actr2 Sec22b Cope Sec23a Sec22a Cd3g Slc2a8 Syt8 Cd3d Syt9 Arpc5 Syt2 Fcho2 Man1a2 Fcho1 M6pr Ldlrap1 Vamp4 Vamp3 Optn LOC100363782 Adrb2 Tbc1d10c Vamp7 Tacr1 Grb2 HIGHLY CALCIUM PERMEABLE NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%R-RNO-629597.1 Highly calcium permeable nicotinic acetylcholine receptors Chrnb4 Chrna4 Chrna5 Chrna6 Chrnb2 Chrnb3 Chrna2 Chrna3 Chrna1 PHASE 1 - INACTIVATION OF FAST NA+ CHANNELS%REACTOME DATABASE ID RELEASE 66%10146070 Phase 1 - inactivation of fast Na+ channels Kcnd3 LOC100911951 Kcnd1 Kcnip3 Kcnip4 Kcnip2 TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR%REACTOME DATABASE ID RELEASE 66%10145903 Trafficking and processing of endosomal TLR Tlr7 MGC114246 Tlr8 Cts8l1 Lgmn Cnpy3 LOC100364523 Unc93b1 RGD1308751 Testin Ctsb Tlr3 Hsp90b1 Ctsl Cts8 Cts7 Tlr9 Ctsm Ctsj RGD1564657 RGD1564827 Ctsk Ctsq Ctsr INTEGRATION OF ENERGY METABOLISM%REACTOME%R-RNO-163685.1 Integration of energy metabolism Plcb1 Cacna1e Slc25a5 Adipor1 Adipor2 Marcks Adipoq Plcb3 Ffar1 Gnaq Gna11 Acly Gna14 Gna15 Prkab2 Tkt Adcy5 Adcy6 Prkar1b Prkar1a Gcgr Kcnj11 Abcc8 Gng10 Fasn Acacb Cacna1c Cacna1d Prkar2b Prkar2a Slc2a2 Adra2a Taldo1 Agpat1 Gnai2 Adra2c Gnb3 Rap1a Gnb5 Kcnc2 Gnb2 Gnb1 Gng13 Gng12 Gng11 Prkaa2 Prkaca Prkacb Itpr1 Cacnb2 Kcns3 Rapgef4 Itpr3 Prkca LOC100912034 Slc2a1 Gnb4 Glp1r Gcg Gng4 Cacna2d2 Gngt2 Gnai1 Gng5 Gngt1 Gng8 Gng3 INTERLEUKIN-10 SIGNALING%REACTOME DATABASE ID RELEASE 66%10145687 Interleukin-10 signaling Il10ra Il10 Jak1 Stat3 Il10rb Tyk2 MITOTIC ANAPHASE%REACTOME DATABASE ID RELEASE 66%10145224 Mitotic Anaphase Cenpn Psmc6 Zwilch Cenpl Nup43 Cenpo Psmb10 Nup133 Dync1li2 Psmb8 Cenpt Psmb9 Cenpu Psmb4 Psmb11 Bub3 Bub1 Psmb5 Psmf1 Psmb6 Spdl1 Psmd4 Kntc1 Psmb2 Dync1i2 Psmd5 LOC100910252 Psmd8 Mad1l1 Stag1 Psmd9 Psmb3 Psma8 Cenpk Cenph Nup37 Cenpi Psmd11 Psmd12 Pds5b Pds5a Cenpf Cdca5 Psmd13 Rad21 Cenpe Psmd14 Smc1a Cenpm Stag2 Smc3 Ahctf1 Ndel1 Rcc2 Pafah1b1 Mis12 Dynll2 Psmc3 Ndc80 Cenpc Cenpa Dync1i1 Ranbp2 Birc5 Taok1 Ube2d1 Ppp2cb Ppp2ca Ppp2r1a Nup85 Anapc7 Cdc26 Cdc27 Cdc23 Pttg1 Ube2c Anapc16 Ppp2r1b Cdc16 Anapc4 Anapc2 Anapc1 Nup98 Nup107 Anapc11 Anapc15 Anapc10 Dync1h1 Cdca8 Dync1li1 Rangap1 Ppp1cc LOC100909468 Aurkb Sec13 Xpo1 LOC100911204 Spc24 Spc25 Hdac8 Itgb3bp Sgol2 Ppp2r5e Incenp G6pc Nsl1 B9d2 Cdc20 Kif2a Kif2c Kif2b Vrk2 Psmb7 Bub1b Psmb1 Kif18a Ppp2r5c Vrk1 Ppp2r5a Ppp2r5b Zwint Dsn1 Espl1 Mad2l1 Casc5 Clasp2 Ercc6l Psma5 Nuf2 Clasp1 LOC679582 Psma2 Mapre1 Psmc5 Psma1 Pmf1 Psmd2 Psma4 Psmc1 Psma3 Psmc4 Psma6 Ckap5 Psmc2 Psme1 Ska2 Psme2 Psmd1 Psmd7 Sgol1 Zw10 Psmd3 Ska1 Psmd6 ZINC EFFLUX AND COMPARTMENTALIZATION BY THE SLC30 FAMILY%REACTOME DATABASE ID RELEASE 66%10145653 Zinc efflux and compartmentalization by the SLC30 family Slc30a5 Slc30a6 Slc30a8 Slc30a1 GABA A RECEPTOR ACTIVATION%REACTOME%R-RNO-977441.1 GABA A receptor activation Gabra5 Gabra6 Gabrb1 Gabrg2 Gabra1 Gabra2 Gabra4 Gabrb2 INTESTINAL ABSORPTION%REACTOME DATABASE ID RELEASE 66%10145282 Intestinal absorption Slc2a5 Npc1l1 Slc2a2 Slc5a1 DEADENYLATION-DEPENDENT MRNA DECAY%REACTOME%R-RNO-429914.1 Deadenylation-dependent mRNA decay LOC100912571 Eif4g1 Wdr61 Lsm7 Lsm6 Lsm4 Lsm3 Lsm5 Cnot6l Pabpc2 Lsm2 Cnot11 Pabpc6 LOC679753 Eif4a2 Eif4a1 LOC680559 LOC100360750 Dcp2 Exosc3 Tnks1bp1 Hbs1l Dcp1a Dcps Exosc9 Cnot8 Exosc2 Lsm1 Rqcd1 Exosc1 Nt5c3b Pan2 Exosc4 Cnot3 Patl1 Cnot1 Ttc37 Exosc7 Zcchc6 Edc3 Exosc5 Edc4 Cnot2 LOC100911431 Pabpc1 Cnot7 Cnot4 Dcp1b Eif4b Eif4a3 EPH-EPHRIN MEDIATED REPULSION OF CELLS%REACTOME%R-RNO-3928665.1 EPH-ephrin mediated repulsion of cells Src Fyn Tiam1 Aph1b Ephb1 Psenen Ephb2 Mmp9 Vav3 Aph1a LOC100911293 Psen2 Psen1 Mmp2 Rac1 Ncstn Ephb4 Lyn Ephb3 Vav2 Efnb2 Yes1 Efnb1 Efnb3 ADRENALINE SIGNALLING THROUGH ALPHA-2 ADRENERGIC RECEPTOR%REACTOME DATABASE ID RELEASE 66%10145560 Adrenaline signalling through Alpha-2 adrenergic receptor Adra2a Adra2c Adra2b MINERALOCORTICOID BIOSYNTHESIS%REACTOME%R-RNO-193993.1 Mineralocorticoid biosynthesis Lhb Hsd3b1 Hsd3b Hsd3b2 LOC100911154 Cyp21a1 Cga Cyp11b2 BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 66%10144858 Base Excision Repair Rfc1 Rfc2 Pole2 Pole4 Rpa1 Rpa2 Lig1 Tdg Mpg Neil1 Ogg1 Xrcc1 Neil2 Mbd4 Parp2 Smug1 Rpa3 Parp1 Pnkp Lig3 LOC100911727 Pole Polb Pold2 Nthl1 Pcna Pold1 Mutyh Pold4 Fen1 Adprhl2 Ung Parg Rfc5 Apex1 Rfc4 Rfc3 INTERLEUKIN-2 FAMILY SIGNALING%REACTOME DATABASE ID RELEASE 66%10145686 Interleukin-2 family signaling Stat5a Jak3 Csf2ra Csf2rb Il21r Stat1 Il2rg Il21 Ptk2b Pik3r3 Pik3r1 Jak1 Pik3r2 Stat3 Il5ra Inpp5d Pik3cd Il9r Il15 Il9 Sos2 Pik3cb Il5 Il2 Ptpn6 Il2ra Csf2 Il3ra Sos1 Shc1 Syk Grb2 Il2rb POST-TRANSLATIONAL PROTEIN PHOSPHORYLATION%REACTOME DATABASE ID RELEASE 66%10146280 Post-translational protein phosphorylation Hrc Mbtps1 Fuca2 Shisa5 Mfi2 Bpifb2 Vwa1 Sdc2 Amtn Cyr61 Csf1 Serpind1 Wfs1 Chgb Igfbp1 Igfbp5 Mgat4a Igfbp4 Enam LOC100909521 Kng1l1 Afp Serpinc1 Bmp4 Mfge8 Igfbp7 Notum Calu Bmp15 Aplp2 Mepe Apoa1 Timp1 Pcsk9 Dmp1 Amelx Prkcsh Pnpla2 Fam20c Tmem132a Mxra8 Lgals1 Nucb1 Fam20a Ambn Tgoln2 Gas6 Fgf23 Apol2 Hsp90b1 App RGD1309808 Msln Lamc1 Tf Apol11a Apol3 LOC100910885 Vgf Apol9a Fbn1 Fstl1 Stc2 Fstl3 Prss23 Fgg Apob Chrdl1 Apoe Fga Apoa2 Cst3 Lamb1 Lamb2 Qsox1 Scg2 Spp1 C4a Scg3 C4b Il6 Ktn1 LOC100909666 Sparcl1 LOC102549354 Men1 Penk LOC100911615 Kng1 Rcn1 Eva1a Kng2 Fn1 Vcan P4hb Cdh2 Dnajc3 C3 Ltbp1 Ckap4 Serpina10 Cp CELLULAR RESPONSES TO STRESS%REACTOME%R-RNO-2262752.1 Cellular responses to stress Hif1an Dync1li2 Mdm2 Vhl Rbx1 Dync1i2 Rpa3 Ncf1 Ncf4 Cited2 Dynll2 Mapkapk5 Dync1i1 Ube2d1 Cdk4 Nup88 Rpa1 Rpa2 Ube2d3 Nup85 Anapc7 Cdc26 Cdc27 Cdc23 Ube2c Cdkn1a Cdkn1b Anapc16 Cdc16 Rae1 Anapc4 Anapc2 Anapc1 Map2k7 Nup93 Dnaja2 Asf1a Camk2g Map2k6 Dnajb6 Dnaja4 Nup98 Ets1 Map2k4 l7Rn6 Nup107 Ep400 Ets2 Tnik Fkbp5 LOC100911837 LOC100910067 Sod1 Camk2d Sod3 Mink1 Camk2a Nup210 Map3k5 Txnrd2 Rps6ka2 Nudt2 Rps6ka1 Hspa14 Hspa13 Rps6ka3 Nox4 Erf LOC100912585 Ubn1 Dnajc7 Anapc11 Nupl2 Anapc15 Cabin1 Hdac6 Anapc10 Nupl1 Ccar2 Hira Fzr1 Hsph1 Hspa12b Hspa12a Nup205 G6pc Nup155 Psmb7 Psmb1 Sod2 Capzb Nup153 P4hb Psma5 Tpr Psma2 Psmd2 Nup54 Psmc2 Pom121 Psmd1 Psmd7 Nup62 Prdx6 Psmd3 Psmd6 Psmc6 Nup43 Psmb10 Nup133 Psmb8 Psmb9 Psmb4 Aaas Psmb11 Psmb5 Psmf1 Psmb6 Rad50 Psmd4 Psmb2 Psmd5 Npap60 Psmd8 Psmd9 Psmb3 Nup35 Psma8 Nup37 Psmd11 Psmd12 Ccna2 Ccna1 Ccne2 Txnrd1 Psmd13 Psmd14 Ccne1 Atm Gsr Cdk2 Egln2 Tceb2 Tceb1 Cul2 Hif1a Limd1 Psmc3 Atr Epas1 Hif3a Egln3 Ajuba Ranbp2 Nbn Mre11a Hsbp1 Dnajb1 Cryab Hsf1 Hspb8 Hspa1l Hsp90ab1 Akt1s1 Hspa2 Cat Jun Ero1l Ywhae Phc1 Phc2 Bag1 Mtor Bag2 Prdx1 Bag4 Mapk9 Bag5 Mapk8 Gpx8 Fos Gpx7 Rptor Bag3 Mapk7 Gpx6 Hspa9 Hspa5 Capza2 Txn1 Prdx3 Capza3 Stip1 Mlst8 Id1 Mapkapk3 Map4k4 Hspa4 Mapkapk2 Ccs Mapk1 Mapk14 Mapk11 Mapk10 Vcp Actr10 Hist1h2bo Dync1h1 Tinf2 Hist1h2bcl1 Scmh1 Hist2h3c2 Cbx4 Hist1h2bk Cbx2 Cbx8 H3f3b Cbx6 Bmi1 Dync1li1 Rnf2 Kdm6b LOC103692716 Ring1 Ptges3 Cybb Cyba Phc3 Ptges3l1 Dctn5 Dctn6 Cdkn2b Terf2ip Fkbp4 Crebbp Dctn4 Cdkn2c Pgr Cdk6 Dctn1 Eed LOC100910200 Txn2 H2afx Dctn2 Hist1h4b Gstp1 LOC684841 Hist1h2bh Acd LOC100912290 Rbbp7 Pot1b Hist1h2ail1 Hist1h4m LOC102549173 LOC103690002 Dctn3 Ehmt2 LOC100910152 Pot1 Ehmt1 LOC100912338 Hist1h3c H2afb3 Hist1h3f Hist2h4 LOC684819 Hist1h3a H2afj Hist2h2aa3 Hist1h2bq Hist2h2aa2 LOC100364835 LOC684762 Terf1 Terf2 LOC100910954 Arnt Mdm4 Psmc5 Psma1 Psma4 Psmc1 Psma3 Psmc4 Psma6 Psme1 Hist1h2bg Psme2 Ezh2 LOC680097 LOC684797 Actr1a LOC100912418 Hist1h2ba Hist3h2bb RECYCLING OF BILE ACIDS AND SALTS%REACTOME%R-RNO-159418.1 Recycling of bile acids and salts Slco1a1 Nr1h4 Slco1a6 Stard5 Ncoa2 Slco1a4 Slco1a2 Rxra Baat Slco1b2 Fabp6 Slc10a1 Slc21a4 Slc27a5 Abcb11 Ncoa1 Slc10a2 METAL ION SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 66%10145650 Metal ion SLC transporters Slc30a5 Slc39a2 Slc11a1 Slc30a6 Slc39a3 Slc30a8 Slc39a4 Slc39a14 Slc39a6 Slc11a2 Slc31a1 Slc30a1 LOC100911874 Slc41a1 Heph Slc41a2 Slc40a1 Slc30a10 Slc39a7 Slc39a8 Cp UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D%REACTOME%R-RNO-75815.1 Ubiquitin-dependent degradation of Cyclin D Psmc6 Psmb10 G6pc Psmb8 Psmb9 Psmb4 Psmb11 Psmb5 Psmf1 Cdk4 Psmb6 Psmd4 Psmb2 Psmd5 Psmd8 Psmb7 Psmd9 Psmb1 Psmb3 Psma8 Ccnd1 Psmd11 Psmd12 Psmd13 Psmd14 Psma5 Psma2 Psmc5 Psmc3 Psma1 Psmd2 Psma4 Psmc1 Psma3 Psmc4 Psmc2 Psma6 Psme1 Psmd1 Psme2 Psmd7 Psmd3 Psmd6 SIGNALING BY FGFR4%REACTOME DATABASE ID RELEASE 66%10145262 Signaling by FGFR4 Src Kras Pik3r1 Frs3 Fgf23 Fgf22 Fgf4 Fgf1 Ppp2cb Fgf3 Ppp2ca Fgf6 Ppp2r1a Fgf5 Fgf20 Mknk1 Gab1 Fgf16 Fgf17 Fgf10 Fgf9 Fgfr2 Fgf2 Fgf7 Cbl Spry2 Fgf8 Fgfr3 Fgfr1 Mapk1 Fgfr4 Ptpn11 Plcg1 Fgf19 Hras Nras Frs2 Sos1 Shc1 Grb2 SODIUM CALCIUM EXCHANGERS%REACTOME DATABASE ID RELEASE 66%10145617 Sodium Calcium exchangers Slc24a4 Slc24a2 Slc24a5 Slc8b1 Sri Slc8a2 Slc8a3 Slc8a1 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE%REACTOME%R-RNO-174411.1 Polymerase switching on the C-strand of the telomere Rfc1 Rfc2 Prim2 Pola2 Prim1 Rfc5 Rfc4 Pold2 Rfc3 Pcna Pold1 Pold4 INTERLEUKIN RECEPTOR SHC SIGNALING%REACTOME%R-RNO-912526.1 Interleukin receptor SHC signaling Jak3 Csf2ra Csf2rb Il2rg Pik3r3 Pik3r1 Jak1 Pik3r2 Il5ra Inpp5d Pik3cb Il5 Il2 Ptpn6 Il2ra Csf2 Il3ra Pik3cd Sos1 Shc1 Grb2 Il2rb REGULATION OF KIT SIGNALING%REACTOME%R-RNO-1433559.1 Regulation of KIT signaling Src Fyn Ptpn6 Prkca Lyn Sh2b2 Yes1 Cbl Sos1 Kit Kitlg Grb2 TRAF6 MEDIATED NF-KB ACTIVATION%REACTOME%R-RNO-933542.1 TRAF6 mediated NF-kB activation Nfkb2 Nfkb1 Ager S100b Dhx9 Nfkbib Chuk Nkiras1 App Nfkbia Nkiras2 Rela Ikbkb Myd88 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS%REACTOME%R-RNO-450531.1 Regulation of mRNA stability by proteins that bind AU-rich elements LOC100912571 Psmc6 Psmb10 Psmb8 Psmb9 Psmb4 Psmb11 Psmb5 Psmf1 Psmb6 Psmd4 Psmb2 Psmd5 Psmd8 Psmd9 Psmb3 Psma8 Psmd11 Psmd12 Psmd13 Eif4g1 Psmd14 Pabpc2 Pabpc6 Psmc3 Xpo1 LOC680559 Prkcd Hspb1 RGD1563307 G6pc Dcp2 Elavl1 Exosc3 Akt1 LOC100911537 Xrn1 Dcp1a Psmb7 Psmb1 Exosc9 Exosc2 Exosc1 Exosc4 Exosc7 Exosc5 LOC100911431 Ywhaz Pabpc1 Ywhab Hnrpd Psma5 Mapkapk2 Psma2 Psmc5 Psmd2 Psma1 Psma4 Psmc1 Psma3 Psmc4 Psmc2 Prkca Psma6 Psme1 Psmd1 Psme2 Psmd7 Khsrp Anp32a Psmd3 Tnfsf13 Psmd6 ANDROGEN BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 66%10145322 Androgen biosynthesis Lhb Pomc Srd5a3 Hsd3b1 Srd5a1 Hsd3b Srd5a2 Hsd3b2 LOC100911154 Hsd17b3 Cga Hsd17b12 ACYL CHAIN REMODELLING OF PI%REACTOME%R-RNO-1482922.1 Acyl chain remodelling of PI Pla2r1 Plbd1 Pla2g5 Pla2g4e Pla2g4d Pla2g16 Pla2g2a Mboat7 Pla2g2f Pla2g10 Pla2g2d LOC103689982 Pla2g1b Pla2g4a LOC686302 Pla2g12a Pla2g4c Pla2g4cl1 GLUCURONIDATION%REACTOME%R-RNO-156588.1 Glucuronidation Ugt2b Ugt1a8 Ugdh Ugt2b37 Ugt1a9 Ugt1a6 Slc35d1 Ugt2b35 Ugt2a1 Ugt2b15 Ugp2 Ugt1a1 Ugt2b17 RGD1559459 Ugt1a7c Ugt1a5 Ugt1a3 Ugt1a2 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS%REACTOME%R-RNO-446219.1 Synthesis of substrates in N-glycan biosythesis Ctsa Mvd Fuom Slc35c1 Fuk Tsta3 Gmds LOC100911225 Fpgt St8sia1 Gfpt2 Nus1 Neu4 Dolpp1 Neu2 Gfpt1 St8sia3 Neu3 Neu1 Renbp St3gal5 Mpi Pgm3 Pmm2 Pmm1 Srd5a3 Nans Slc35a1 St8sia5 Slc17a5 St6galnac1 St6galnac2 Nudt14 Npl LOC501189 Dhdds Cmas St8sia4 Nanp LOC100910177 Dolk St6gal1 St6gal2 Glb1 Amdhd2 St6galnac4 St3gal2 St6galnac3 St3gal3 Nagk Gne St3gal1 St6galnac6 Gnpnat1 Dpm3 Dpm2 St3gal4 Dpm1 St3gal6 Uap1 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION%REACTOME%R-RNO-983231.1 Factors involved in megakaryocyte development and platelet production Kif21a Kif21b Kifc1 Kif3c Dock5 Racgap1 Klc1 Dock3 Kif22 Kif3b Rad51c Kif23 Sh2b1 Kif18b Rcor1 Kifap3 Dock9 Kif11 Dock8 Dock6 Kif12 Kif4a Mical1 Rac1 Kif6 Lrrc16a Kif1a Akap1 Kif1c Gata4 Gata2 LOC100911167 Kif27 Klc4 Kif9 Kdm1a Cenpe Kif13b Klc2 Gata1 Klc3 Prkar1b Prkar1a Mfn1 Mfn2 LOC100911485 Kif3a Dock11 Ehd3 Ehd2 Ehd1 Hmg20b Phf21a Mafk Mafg Maff Cbx5 Nfe2 Akap10 Ak3 Rbsn Jmjd1c Zfpm2 LOC100909609 Zfpm1 Dock7 Hdac1 Capza2 Kif20b Prkaca Prkacb Kif16b Kif26a Kif20a Kif26b Kif19 Dock1 Sh2b2 Itpk1 Hist2h3c2 H3f3b Hdac2 Hdac1l Gata3 LOC684841 Hist1h2ail1 LOC102549173 Kif2a Kif2c Kif2b Hist1h3c Kif18a Hist1h3f Prkar2b LOC684819 Prkar2a Hist1h3a Capzb Kif5b Kif5a LOC684762 Cdc42 MRNA SPLICING%REACTOME DATABASE ID RELEASE 66%10144829 mRNA Splicing Cwc27 Cwc25 Cwc22 Snrpf Wdr33 Ppie RGD1565904 Isy1 Polr2g Polr2h Polr2e Snrnp25 Polr2f Zrsr1 Zcrb1 Polr2j Polr2k Zmat5 Polr2d Snrnp48 Polr2i Rnpc3 Polr2b Zrsr2 Polr2c Snrnp35 Polr2a Pdcd7 Xab2 LOC100912534 Prpf19 Srsf3 Ccar1 Cdc5l Upf3b U2af2 LOC102548514 Cd2bp2 Papola Srsf6 Elavl1 Srsf7 Ppil6 Prpf38a Srsf4 Srsf5 Srsf2 Hnrnph1 Ppih LOC100359574 Ppil1 Ppil3 Elavl2 Srsf9 Ppil4 Dhx38 LOC100911822 Fblim1 Clp1 Aqr Hnrnph2 Cwc15 Cherp Magoh Hnrpd Ncbp2 Srsf1 LOC100363335 Ctnnbl1 Ppwd1 LOC500684 Ncbp1 LOC680519 Dhx9 Ybx1 LOC100910750 Nhp2l1 Cstf2t Eif4a3 Sympk Bud31 Hnrnpul1 Txnl4a LOC100910660 Hnrnpk Srrm1 Hnrnpu Hnrnpr Wbp4 Usp39 Hnrnpl Snrpa Hnrnpm Hnrnpf Cdc40 Snrpc Hnrnpa2b1 Snrpb Rnps1 Dhx16 Dhx15 Sugp1 Prpf40a Sart1 Snrpb2 Magohb Phf5a Rbm8a Ddx23 Pcf11 Fip1l1 Hnrnpa0 U2surp Nudt21 Snrpd1 Eftud2 LOC100364748 Snrpd2 Snrpd3 Rbm5 Tra2b Sf3b2 Sf3b4 Sf3b3 Pqbp1 Sf3b5 Cstf2 Rbm22 Lsm8 Puf60 Wbp11 Lsm7 U2af1l4 Gtf2f1 Lsm6 Gtf2f2 Lsm4 Lsm3 Lsm5 Cpsf7 Cpsf2 Cpsf3 Cpsf4 Lsm2 Rbm17 Snw1 Cstf1 Snrnp200 Cpsf1 Smptb Gpkow Plrg1 LOC679753 Prpf6 Sf3a3 Sf3b1 Prpf8 Prpf4 Ddx5 Ddx46 Sf3a1 Prpf31 Ddx42 Bcas2 Prpf3 Sf3a2 Crnkl1 LOC100360750 Syf2 Fus Smndc1 Prcc Rbmx LOC100359916 Snrpa1 Snrnp70 FRUCTOSE CATABOLISM%REACTOME%R-RNO-70350.1 Fructose catabolism Aldob Khk Glyctk Tkfc METABOLISM OF FAT-SOLUBLE VITAMINS%REACTOME DATABASE ID RELEASE 66%10145778 Metabolism of fat-soluble vitamins Agrn Gpihbp1 Pnlip Akr1b7 Akr1b8 Apoa1 Sdc2 Sdc3 Sdc4 Clps Gpc6 Akr1c2 Gpc4 Gpc2 Rbp4 Akr1c12l1 Akr1c3 Ubiad1 Ttr Lrp1 Lrp10 Rbp2 Tex12 Rbp1 Lrp8 Ttpa Apom Lrp12 Lpl Akr1c19 Apob Bco1 Apoc2 Rdh11 Apoe Apoa2 Lrat Bco2 Gpc1 Akr1c13 Akr1c14 RGD1564865 Akr1c12 Akr1c1 NGF PROCESSING%REACTOME DATABASE ID RELEASE 66%10145269 NGF processing Ngf Pcsk6 Pcsk5 Furin BETA-CATENIN PHOSPHORYLATION CASCADE%REACTOME%R-RNO-196299.1 Beta-catenin phosphorylation cascade Peg12 Amer1 Csnk1a1 Frat2 Ppp2r5e Apc Ppp2r1b LOC100909468 Ppp2r5c Ppp2r5a Ppp2cb Ppp2ca Ppp2r5b Ppp2r1a SYNDECAN INTERACTIONS%REACTOME%R-RNO-3000170.1 Syndecan interactions Vtn Prkca Itgb4 Itga6 Sdc2 Tgfb1 Fgf2 Sdc3 Sdc4 MET RECEPTOR RECYCLING%REACTOME DATABASE ID RELEASE 66%10146253 MET receptor recycling Gga3 Gab1 Hgf Crk Crkl Rab4b Arf6 Rab4a Grb2 LOC100911248 IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX%REACTOME DATABASE ID RELEASE 66%10144904 Import of palmitoyl-CoA into the mitochondrial matrix Cpt1b Cpt2 Thrsp Cpt1a Ppard Mid1ip1 Rxra Slc25a20 Prkab2 Prkaa2 Slc22a5 COSTIMULATION BY THE CD28 FAMILY%REACTOME DATABASE ID RELEASE 66%10145355 Costimulation by the CD28 family Cd80 Cd86 Map3k8 Rac1 Cd4 Rictor Fyn Trib3 LOC100909468 Pak2 Pak3 Pak1 Them4 Akt2 Src Ppp2r5e Pik3r1 Pik3r3 Pik3r2 Pdcd1lg2 Tnfrsf14 Btla Akt1 Icoslg Cd28 Pdcd1 Cd274 LOC100911478 Cd3e Icos Ppp2r5c Ppp2cb Ppp2r5a RT1-Ba Ppp2ca RT1-Bb RT1-Da Ppp2r1a RT1-Db2 Ppp2r5b RT1-Db1 LOC688090 Vav1 Mtor Cd247 Csk Ppp2r1b Mlst8 Pdpk1 Mapkap1 Cdc42 Cd3g Akt3 Map3k14 Ptpn11 Cd3d Ptpn6 Lyn Yes1 Grb2 G1 S TRANSITION%REACTOME DATABASE ID RELEASE 66%10144724 G1 S Transition Psmc6 Psmb10 Psmb8 Pole2 Psmb9 Pole4 Psmb4 Psmb5 Psmf1 Psmb6 Psmd4 Mnat1 Psmb2 Psmd5 Psmd8 Psmd9 Psmb3 Psmd11 Psmd12 Prim2 Ccna2 Ccne2 Pola2 Ccna1 Psmd13 Prim1 Ccne1 Psmd14 Mcm2 Mcm4 Mcm3 Cdk2 Mcm5 Rpa3 Mcm6 Pole Mcm10 Psmc3 Ccnh Mcm8 Mcm7 Orc4 Orc5 Orc6 Orc1 Orc2 Orc3 Cdc7 Cdc6 Cdc45 Cdk4 Akt1 Rpa1 Ppp2cb Ccnd1 Ppp2ca Rpa2 Skp1 Ppp2r1a Skp2 Cdkn1a Cdkn1b Ppp2r1b Akt3 Ppp2r3b Cul1 Ptk6 Cks1l Cables1 Cks1b Akt2 Gmnn G6pc Rb1 Psmb7 Psmb1 Psma5 Cdk7 Cdt1 Psma2 Psmc5 Psma1 Psmd2 Psma4 Psmc1 Cdc25a Psma3 Wee1 Psmc4 Psma6 Psmc2 Psme1 Psmd1 Psme2 Psmd7 Psmd3 Psmd6 PHOSPHO-PLA2 PATHWAY%REACTOME DATABASE ID RELEASE 66%10144988 phospho-PLA2 pathway Pla2g4a Mapk1 NRAGE SIGNALS DEATH THROUGH JNK%REACTOME%R-RNO-193648.1 NRAGE signals death through JNK Arhgef6 Arhgef5 Arhgef39 Arhgef7 Arhgef37 Arhgef38 Arhgef33 Prex1 Itsn1 Arhgef2 Rac1 LOC102556447 Arhgef4 Arhgef3 Plekhg5 Arhgef19 Arhgef18 Plekhg2 Kalrn Bcl2l11 LOC100912512 Vav2 Gna13 Vav1 Arhgef11 Akap13 Arhgef16 Arhgef15 Bad Net1 Ect2 Arhgef26 Fgd2 Mapk8 Mcf2l Tiam1 Tiam2 Vav3 Fgd3 Sos2 Ngef Sos1 HDR THROUGH HOMOLOGOUS RECOMBINATION (HRR)%REACTOME%R-RNO-5685942.1 HDR through Homologous Recombination (HRR) Rhno1 Rfc1 Bard1 Rfc2 Wrn Topbp1 Rbbp8 Rmi1 Pole2 Rmi2 Pole4 Rad51c Polh LOC100911267 Spidr Rad51d Eme2 Rad51 Eme1 Brca2 Rtel1 Rad50 Atm Atrip Rpa3 Pole Pcna Xrcc3 Rad1 Brca1 Blm Atr Slx4 Mus81 Rad17 Slx1b Palb2 Gen1 Rfc5 Xrcc2 Rad9a Rfc4 Nbn Rfc3 Rad9b Mre11a Hus1 Rpa1 Rpa2 Pold2 Pold1 Pold4 Slc25a16 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE%REACTOME%R-RNO-532668.1 N-glycan trimming in the ER and Calnexin Calreticulin cycle Edem3 Calr Man1b1 Rnf139 Ganab Derl1 Edem2 Engase Uggt1 Trim13 Rad23b Mlec Rnf5 Ngly1 Prkcsh Vcp Ubxn1 Psmc1 Canx Rnf103 March6 Os9 Sel1l IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL%REACTOME%R-RNO-198933.1 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell PVR Cd40 Cd34 Siglec1 Mill1 LOC680910 LOC685157 Itgb7 Cd200 Hcst Madcam1 Cd300lb Itgb2 Cd300le Colec12 Kir3dl1 Pianp Itga4 Cd300e Cd300lg Cd1d1 Cd300lf Crtam LOC685048 RGD1559588 Sh2d1b2 RT1-A Pilra Cd22 RGD1566006 LOC685438 Trem1 Ifitm3 Cd40lg Cd226 LOC100911324 RT1-A2 Pvrl2 RT1-M3-1 Ifitm2 RT1-A1 Ifitm1 Sh2d1a Sh2d1b Cd8b B2m Cd19 Cd8a RGD1561143 Slamf7 Cd81 Siglec10 Slamf6 RGD1561778 Npdc1 Treml2 RT1-M2 LOC100364500 Cd200r1 RT1-M5 Cd200r1l RT1-M4 LOC681182 Cd96 RT1-S3 Itgal Icam4 RT1-CE2 Icam5 RT1-CE3 RT1-CE4 RT1-CE7 RT1-CE5 Icam1 Vcam1 RT1-CE10 Trem2 Cd3e Cd247 RGD1559482 C3 RT1-M6-1 Lair1 LOC683761 LOC100364956 Cd3g RT1-M6-2 Cd3d Icam2 GAMMA-CARBOXYLATION, TRANSPORT, AND AMINO-TERMINAL CLEAVAGE OF PROTEINS%REACTOME DATABASE ID RELEASE 66%10145094 Gamma-carboxylation, transport, and amino-terminal cleavage of proteins Ggcx Pros1 Proz Bglap F2 F7 F9 Gas6 Furin NOTCH4 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME DATABASE ID RELEASE 66%10146329 NOTCH4 Activation and Transmission of Signal to the Nucleus Ywhaz Notch4 PHOSPHATE BOND HYDROLYSIS BY NUDT PROTEINS%REACTOME DATABASE ID RELEASE 66%10145964 Phosphate bond hydrolysis by NUDT proteins Adprm Nudt9 Nudt5 Nudt16 Nudt18 LOC688828 Nudt15 Nudt1 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS%REACTOME DATABASE ID RELEASE 66%10145963 Non-integrin membrane-ECM interactions Fgf2 Ttr Ddr1 Pdgfa Pdgfb Prkca Vtn Itgb4 Itga6 Sdc2 Sdc3 Tgfb1 Sdc4 MITOTIC METAPHASE ANAPHASE TRANSITION%REACTOME DATABASE ID RELEASE 66%10145108 Mitotic Metaphase Anaphase Transition Fbxo5 CILIUM ASSEMBLY%REACTOME DATABASE ID RELEASE 66%10146080 Cilium Assembly Kif3c Kif3b Kifap3 Arf4 Dync1i2 Nphp1 Cep57 Cep97 Rab8a B9d1 Cep162 LOC691918 Gbf1 Haus3 Ninl Akap9 Nphp4 Ccp110 Tmem216 Rpgrip1l Pafah1b1 Smo Wdr35 Kif3a Ift88 Dynll2 Cngb1 Inpp5e Tubb5 Ywhag Ppp2r1a Exoc3 Exoc2 Exoc1 Exoc6 Ywhae Exoc5 Exoc8 Exoc7 Nek2l1 Prkaca Nek2 Hdac6 Dync1h1 Ttc8 Bbs9 Bbs1 LOC103692716 Bbs2 Mchr1 Arl6 Rab3ip Lztfl1 Trip11 Mks1 Dctn1 C2cd3 Cntrl Ift81 Dctn2 Cep76 Sept2 Pcm1 Cep78 LOC100912537 Ttbk2 Mark4 B9d2 LOC100911033 Cep164 Dctn3 Ofd1 Cep41 Sclt1 Sstr3 Tctn1 Sdccag8 Bbs7 Bbs5 Bbs4 Cep83 Prkar2b Cenpj Cep89 Plk4 Ift122 Wdr19 Ttc21b Ahi1 LOC100912076 Tubg2 Haus2 Haus1 Ift46 Ift43 Haus5 Alms1 Wdr60 Clasp1 Kif17 Haus4 Tnpo1 Odf2 Pde6d Tubb4a Cdk1 Iqcb1 Dynlrb2 Rab11a Ift74 Tmem67 Ttc26 Ssna1 Dynlrb1 Tubg1 Mapre1 Tcte3 Cep63 Dync2li1 Csnk1d Atat1 Cep131 Ift52 Pkd2 Tuba4a Pkd1 Cep250 Hspb11 Cnga4 Cep135 Ift57 Cnga2 Csnk1e Traf3ip1 Cdk5rap2 Ckap5 Ift27 Kif24 Arl13b Pcnt Ift22 Cep72 Ift20 Sfi1 Cluap1 Cep70 Tctex1d1 Actr1a Tctex1d2 LOC100911746 Ift140 Ttc30b Nedd1 Ift80 Fbf1 BETA OXIDATION OF MYRISTOYL-COA TO LAUROYL-COA%REACTOME%R-RNO-77285.1 Beta oxidation of myristoyl-CoA to lauroyl-CoA Acadl Hadha Hadhb CELLULAR HEXOSE TRANSPORT%REACTOME%R-RNO-189200.1 Cellular hexose transport Slc2a9 Slc45a3 Slc2a6 Slc2a4 Fgf21 Slc5a10 Slc50a1 Slc5a1 Slc5a4 Slc5a2 RGD1559971 Slc2a8 Slc2a1 Slc2a2 RGD1561777 Slc5a9 Slc2a12 Slc2a10 RGD1304770 CARGO CONCENTRATION IN THE ER%REACTOME DATABASE ID RELEASE 66%10146150 Cargo concentration in the ER Areg Ctsc Stx5 Tmed2 Sec24a Sec24b Cnih1 Sec24d Ctsz Ctage5 Mcfd2 Preb Cnih3 Cnih2 Cd59 Tgfa Sec22b Sec23a Lman1l Sar1b Col7a1 F8 Lman2 Sec24c Gosr2 Folr1 Lman1 Tmed10 BIOSYNTHESIS OF SPECIALIZED PRORESOLVING MEDIATORS (SPMS)%REACTOME%R-RNO-9018678.1 Biosynthesis of specialized proresolving mediators (SPMs) Cyp2d5 Alox5 Lta4h Alox5ap Hpgd LOC100361547 Gpx4 Cyp3a23/3a1 Cyp3a73 Cyp2c7 Alox12 Cyp2e1 Ltc4s Gstm4 Cyp2d4 Cyp3a18 Cyp1a1 LOC100910877 Cyp2d2 Ptgs2 Ephx2 Cyp1a2 Alox15 Cyp2d3 Cyp2c6v1 DOWNSTREAM SIGNALING OF ACTIVATED FGFR3%REACTOME%R-RNO-5654708.1 Downstream signaling of activated FGFR3 Kras Pik3r1 Frs3 Fgf23 Fgf22 Fgf4 Fgf1 Fgf3 Fgf6 Fgf5 Fgf20 Gab1 Fgf16 Fgf17 Fgf10 Fgf9 Fgfr2 Fgf7 Fgf2 Fgf8 Fgfr3 Fgfr1 Fgfr4 Ptpn11 Plcg1 Fgf19 Hras Nras Frs2 Sos1 Shc1 Grb2 BIOSYNTHESIS OF DHA-DERIVED SULFIDO CONJUGATES%REACTOME%R-RNO-9026395.1 Biosynthesis of DHA-derived sulfido conjugates Ltc4s Gstm4 LOCALIZATION OF THE PINCH-ILK-PARVIN COMPLEX TO FOCAL ADHESIONS%REACTOME%R-RNO-446343.1 Localization of the PINCH-ILK-PARVIN complex to focal adhesions Ilk ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT)%REACTOME%R-RNO-917729.1 Endosomal Sorting Complex Required For Transport (ESCRT) Ubap1 Vps4b Chmp2b Chmp2a Mvb12b Vps25 Mvb12a Chmp5 Chmp7 Snf8 Vps36 Chmp4b Chmp6 Chmp3 Chmp4c Chmp4bl1 LOC100910929 Tsg101 Vta1 Vps37a Stam2 Vps37d Vps37c Vps37b Stam MAPK3 (ERK1) ACTIVATION%REACTOME%R-RNO-110056.1 MAPK3 (ERK1) activation Ptpn11 Il6st Jak1 Il6 Cdk1 Tyk2 PEPTIDE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145486 Peptide ligand-binding receptors Npff Npffr2 RGD1560028 Hcrt Psap Npffr1 Qrfp LOC100909783 Kng1l1 F2rl3 Hcrtr1 F2r Qrfpr Cxcr2 F2 Hcrtr2 F2rl2 Hebp1 Uts2 Ntsr2 Fpr-rs6 Ccr6 Trhr Nmu Pf4 Fpr-rs3 Mc5r Fpr2 Fpr3 Pomc Ntsr1 Anxa1 Pmch Rxfp1 Rxfp2 Kel Insl3 Fpr-rs4 Tac3 Kiss1 Rxfp3 Tac1 Edn2 Ednra Ednrb Edn3 Grp Grpr Cx3cr1 Edn1 F2rl1 Sst Oxtr Ackr4 Ackr3 Oxt LOC100909648 Nmb Avpr1b Xcl1 Cxcl9 Avpr1a Cxcl6 Cx3cl1 Cxcl2 Cxcl1 Agt Cxcl3 Agtr2 Prlh Galr1 Ccrl2 Nts Oprk1 Oprl1 Agtr1b Ccl21 Agtr1a Prokr2 Mc3r Ccr5 Fpr1 Gal Ccr4 Ccr3 Gpr37 Ccl27 Cckar Gper1 Ccl20 Uts2r Prokr1 Ccl25 NMS Xcr1 Cxcl16 Pdyn Prlhr Ccr10 Gpr37l1 Ccl19 Ccr7 Ccr8 Cxcr3 Cxcl10 Ccr9 Cxcl11 Avp Ece2 Ece1 Xk Sstr5 Brs3 Npbwr1 C5ar2 Pyy Pnoc Ccl5 Npy2r Mc4r Prok2 Oprm1 Prok1 Mchr1 Sstr1 Aplnr Sstr4 Sstr2 Cck Npy1r Apln Tacr3 Tacr2 Bdkrb1 Bdkrb2 Rln3 Npb Ppy Trh Ccl1 Npw Mc2r Npy Nps C3ar1 Cxcl12 Sstr3 Penk C5ar1 Kng1 Cxcr4 Kng2 C3 Ppbp Cckbr Cxcr5 Uts2b Npy5r Nmur2 Cxcr6 Oprd1 Tacr1 BIOSYNTHESIS OF EPA-DERIVED SPMS%REACTOME%R-RNO-9018679.1 Biosynthesis of EPA-derived SPMs Hpgd Gpx4 Alox5 Ptgs2 Alox15 Lta4h HORMONE LIGAND-BINDING RECEPTORS%REACTOME%R-RNO-375281.1 Hormone ligand-binding receptors Gphb5 Gnrhr Gpha2 Gnrh1 Fshb Fshr Tshr Lhb Lhcgr LOC100909513 Tshb LOC100360745 Cga BIOSYNTHESIS OF DPA-DERIVED SPMS%REACTOME%R-RNO-9018683.1 Biosynthesis of DPA-derived SPMs Alox12 Alox5 Ptgs2 Alox15 SIGNALING BY PTK6%REACTOME%R-RNO-8848021.1 Signaling by PTK6 Ereg Nrg1 Kras Btc LOC100909609 LOC102552659 Erbb3 Erbb2 Pxn Srms Nrg3 Ptpn1 Stat3 Egfr Hbegf Cdk4 Akt1 Rac1 Arhgap35 Ptk6 Nrg4 Socs3 Ccnd1 Dok1 Ccne1 Cdk2 Arap1 Crk Cdkn1b Lrrk2 Bcar1 Stap2 Cbl Khdrbs2 Hif1a Gpnmb Khdrbs1 Khdrbs3 Rhoa Dock1 Erbb4 Hras Nras Elmo2 Rasa1 Nrg2 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%R-RNO-975144.1 IRAK1 recruits IKK complex upon TLR7 8 or 9 stimulation LOC100362142 Ube2n LOC100912618 Peli3 Ube2v1 Chuk Ikbkb Peli2 Traf6 Peli1 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS%REACTOME%R-RNO-390471.1 Association of TriC CCT with target proteins during biosynthesis Cct6b Cct8 Cct6a Tcp1 Cct7 Cct2 Cct4 Cct3 NCAM SIGNALING FOR NEURITE OUT-GROWTH%REACTOME DATABASE ID RELEASE 66%10145367 NCAM signaling for neurite out-growth Kras Fyn Ptpra Col9a1 Col9a2 Col9a3 Ncam1 Col4a1 Sptbn1 Sptan1 LOC501189 St8sia4 Mapk1 Spta1 Col4a2 Rps6ka5 Creb1 Hras Nras Ptk2 Sos1 Grb2 DOWNSTREAM SIGNAL TRANSDUCTION%REACTOME%R-RNO-186763.1 Downstream signal transduction Stat5a Src Kras Grb7 Stat1 Pik3r1 Pdgfra Pik3r2 Pdgfrb Stat3 Nck1 Pdgfa Pdgfb Stat6 Crk Bcar1 Pik3cb Ptpn11 Plcg1 Hras Crkl Nras Sos1 Rasa1 Rapgef1 Nck2 LOC100911248 Grb2 HDR THROUGH HOMOLOGOUS RECOMBINATION (HRR) OR SINGLE STRAND ANNEALING (SSA)%REACTOME%R-RNO-5693567.1 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) Rfc1 Rhno1 Rfc2 Bard1 Wrn Topbp1 Rbbp8 Rmi1 Pole2 Rmi2 Rad51c Pole4 Polh LOC100911267 Spidr Rad51d Eme2 Rad51 Brca2 Eme1 Rtel1 Rad50 Ppp4r2 Ppp4c Ccna2 Ccna1 Atm Atrip LOC100909750 Cdk2 Rpa3 Pole Pcna Xrcc3 Brca1 Rad1 Blm Atr Slx4 Mus81 Rad17 Slx1b Palb2 Sirt6 Gen1 Rfc5 Xrcc2 Rfc4 Rad9a Nbn Rfc3 Abl1 Rad9b Mre11a Hus1 Rad52 Rpa1 Rpa2 Ercc1 Pold2 Pold1 Pold4 Slc25a16 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE%REACTOME DATABASE ID RELEASE 66%10145601 Nitric oxide stimulates guanylate cyclase Pde1b Pde9a Pde3b Pde5a Pde3a LOC497963 Nos3 Itpr1 Prkg2 Pde2a Cyct Mrvi1 Pde10a Nos1 Pde11a ER QUALITY CONTROL COMPARTMENT (ERQC)%REACTOME DATABASE ID RELEASE 66%10145712 ER Quality Control Compartment (ERQC) Edem3 Man1b1 Rnf139 Rnf103 Edem2 March6 Uggt1 Trim13 Os9 Rnf5 Sel1l TRAFFICKING OF AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145593 Trafficking of AMPA receptors Ap2a2 Camk2g Mdm2 Dlg1 Gria3 Gria4 Grip1 Grip2 Camk2d Pick1 Camk2a Cacng8 Akap5 Prkca Prkcb Nsf Ap2s1 Cacng2 Cacng3 Cacng4 Ap2a1 Myo6 Dlg4 Ap2m1 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE%REACTOME%R-RNO-210500.1 Glutamate Neurotransmitter Release Cycle Slc1a3 Slc38a2 Slc1a7 Rab3a Slc1a6 Slc17a7 Slc1a1 Rims1 Cplx1 Stx1a Syt1 Vamp2 Stxbp1 Ppfia1 Ppfia2 Ppfia3 Ppfia4 Bzrap1 RAP1 SIGNALLING%REACTOME DATABASE ID RELEASE 66%10145480 Rap1 signalling Prkaca Prkacb Rapgef4 Rasgrp1 Rasgrp2 Raf1 Rap1a Ywhaz Rap1gap Ywhab Rap1gap2 Sipa1 MISMATCH REPAIR (MMR) DIRECTED BY MSH2:MSH6 (MUTSALPHA)%REACTOME DATABASE ID RELEASE 66%10146059 Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Msh2 Rpa3 LOC100911727 Pold2 Pold1 Pcna Pold4 Rpa1 Rpa2 Pms2 Mlh1 Msh6 Lig1 INTERLEUKIN-36 PATHWAY%REACTOME%R-RNO-9014826.1 Interleukin-36 pathway Il1rl2 Il36rn Il1f10 Il1rap Il36b Il36a SYNTHESIS OF PG%REACTOME%R-RNO-1483148.1 Synthesis of PG Cds2 SYNTHESIS OF PI%REACTOME%R-RNO-1483226.1 Synthesis of PI Cds1 Cdipt Pitpnm1 Pitpnm3 Pitpnm2 SYNTHESIS OF ACTIVE UBIQUITIN: ROLES OF E1 AND E2 ENZYMES%REACTOME DATABASE ID RELEASE 66%10146214 Synthesis of active ubiquitin: roles of E1 and E2 enzymes Ube2g2 LOC100911393 Ube2g1 Ube2q2 Usp7 Ube2r2 Ube2c Usp9x Ube2d1 Ube2k Ube2z Ube2h Uba6 Ube2a Ube2t Ube2s Uchl3 RGD1561252 Usp5 Cdc34 Ube2e3 Otulin LOC100911959 Uba1 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE%REACTOME%R-RNO-442720.1 CREB phosphorylation through the activation of Adenylate Cyclase Adcy8 Adcy3 TNFR1-INDUCED NFKAPPAB SIGNALING PATHWAY%REACTOME DATABASE ID RELEASE 66%10146055 TNFR1-induced NFkappaB signaling pathway Rnf31 Sharpin Usp2 Traf1 Rbck1 Usp21 Birc3 Birc2 Otud7b Cyld Chuk Traf2 Usp4 LOC100910771 Tab2 Tab3 Tab1 Ripk1 Ikbkb Tnf Tradd Xiap Map3k7 Tnfaip3 BIOSYNTHESIS OF MARESIN-LIKE SPMS%REACTOME DATABASE ID RELEASE 66%10146318 Biosynthesis of maresin-like SPMs LOC100361547 Cyp3a23/3a1 Cyp3a73 Cyp2d5 Cyp2c7 Cyp2e1 Cyp2d4 Cyp3a18 LOC100910877 Cyp2d2 Cyp1a2 Cyp2d3 Cyp2c6v1 CONJUGATION OF BENZOATE WITH GLYCINE%REACTOME%R-RNO-177135.1 Conjugation of benzoate with glycine Glyatl3 Acsm1 Glyat ABC-FAMILY PROTEINS MEDIATED TRANSPORT%REACTOME DATABASE ID RELEASE 66%10145462 ABC-family proteins mediated transport Psmc6 Eif2s3 Psmb10 Psmb8 Psmb9 Psmb4 Psmb11 Psmb5 Psmf1 Abcd1 Psmb6 Psmd4 Psmb2 Vcp LOC688708 Psmd5 Psmd8 Psmd9 Psmb3 Psma8 Psmd11 Psmd12 Eif2s1 Eif2s2 Psmd13 Psmd14 Derl1 Psmc3 Kcnj11 Abcc9 G6pc Psmb7 Psmb1 Apoa1 Os9 Erlec1 Abcd2 Abcc4 Abcc2 Abcc6 Psma5 Abcd3 Abcb8 Abcb9 Derl3 Erlin2 Abcb10 Rnf5 Pex3 Abcb5 Psma2 Abcb6 Psmc5 Abca4 Psma1 Psmd2 Abca3 Psma4 Abcf1 Psmc1 Abca2 Psma3 Abcc10 Psmc4 Erlin1 Psma6 Psmc2 Abca6 Psme1 Abca5 Abcg4 Abcg1 Psmd1 Psme2 Psmd7 Abcb1a Abca7 Sel1l Abcg8 Psmd3 Abcg5 Psmd6 TRANSPORT OF GLYCEROL FROM ADIPOCYTES TO THE LIVER BY AQUAPORINS%REACTOME DATABASE ID RELEASE 66%10145643 Transport of glycerol from adipocytes to the liver by Aquaporins Aqp7 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE%REACTOME%R-RNO-606279.1 Deposition of new CENPA-containing nucleosomes at the centromere Cenpn LOC100910200 Cenpl H2afx Cenpo Hist1h4b Mis18bp1 Hist1h2bh Cenpt Cenpu LOC100912290 Rbbp7 Hist1h4m LOC103690002 LOC100910152 LOC100912338 H2afb3 Cenpk Hist2h4 Cenph Cenpi Hjurp H2afj Hist2h2aa3 Hist1h2bq Hist2h2aa2 Cenpm Casc5 LOC100364835 Hist1h2bo Hist1h2bcl1 Hist1h2bk Cenpc Cenpa Cenpw Hist1h2bg Ruvbl1 LOC100911204 Smarca5 LOC680097 LOC684797 LOC100912418 Hist1h2ba Hist3h2bb Itgb3bp INTERCONVERSION OF 2-OXOGLUTARATE AND 2-HYDROXYGLUTARATE%REACTOME%R-RNO-880009.1 Interconversion of 2-oxoglutarate and 2-hydroxyglutarate D2hgdh Adhfe1 L2hgdh HS-GAG DEGRADATION%REACTOME%R-RNO-2024096.1 HS-GAG degradation Gpc6 Agrn Gpc4 Gpc2 Glb1l Glb1 Gusb Hpse Sdc2 Sdc3 Gpc1 Naglu Sdc4 Idua GABA B RECEPTOR ACTIVATION%REACTOME%R-RNO-977444.1 GABA B receptor activation Kcnj4 Kcnj6 Gnai3 Gnal Gnat3 Adcy3 Adcy8 Adcy9 Adcy5 Gnai2 Adcy4 Adcy7 Adcy6 Gnb3 Kcnj16 Gnb2 Gnb1 Gng12 Kcnj2 Kcnj3 Kcnj15 Kcnj9 Kcnj5 Gng4 Gngt2 Gnai1 Gng5 Gabbr1 Gngt1 Kcnj12 Gng10 Gng8 Gabbr2 Gng3 GLYCEROPHOSPHOLIPID CATABOLISM%REACTOME DATABASE ID RELEASE 66%10146195 Glycerophospholipid catabolism Enpp6 Pnpla6 PI3K AKT SIGNALING%REACTOME%R-RNO-1257604.1 PI3K AKT Signaling Ereg Nrg1 Trim27 Btc Usp7 LOC102552659 Mdm2 Erbb3 Erbb2 Nrg3 Egfr Hbegf Esr2 Nrg4 Csnk2a2 Nr4a1 Csnk2a1 Pml Fyn Il1rap Nrg2 Pik3ap1 Il1rl1 Akt1 Hdac1 Phlpp1 Ier3 Pdgfa Rps6kb2 Pdgfb Foxo1 Foxo3 Pik3cd Stub1 Irak4 Cdkn1a Cdkn1b Traf6 Il33 Pip5k1c Pip5k1b Pip5k1a Cd19 LOC100909468 Hgf Rac2 Ppp2r5e G6pc Pdgfra Pdgfrb Frk Psmb7 Psmb1 Ppp2r5c Ppp2r5a Ppp2r5b Vav1 Foxo4 Psma5 Pdpk1 Psma2 Psmd2 Psmc2 Psmd1 Psmd7 Kit Kitlg Psmd3 Psmd6 Psmc6 Pten Psmb10 Psmb8 Psmb9 Psmb4 Psmb11 Psmb5 Psmf1 Psmb6 Rac1 Psmd4 Psmb2 Psmd5 Psmd8 Psmd9 Psmb3 Psma8 Psmd11 Psmd12 Psmd13 Psmd14 RragB Rictor Fgf2 Psmc3 Pip4k2b Pip4k2c Src Pik3r3 Akt1s1 Ppp2cb Ppp2ca Ppp2r1a Xiap Tnks Phc1 Phc2 Mtor Rheb Rptor Lamtor4 Chuk Lamtor5 Ppp2r1b Mlst8 Tsc2 Rraga Mapk1 Rragc Akt3 Rragd Slc38a9 Creb1 Myd88 Cd80 Cd86 Otud3 Fgf23 Fgf22 Fgf4 Fgf1 Fgf3 Fgf6 Fgf5 Lamtor3 Fgf20 Gab1 Sall4 Scmh1 Cbx4 Cbx2 Cbx8 Fgf16 Lamtor2 Cbx6 Fgf17 Lamtor1 Bmi1 Irs2 Hdac2 Fgf10 Fgf9 Rnf2 Fgfr2 Mbd3 Fgf7 Usp13 Fgf8 Ring1 Hdac1l Fgfr3 Chd3 Trib3 Chd4 Phc3 Fgfr1 Prex2 Fgfr4 Esr1 Insr Ins1 Ins2 Mta3 Fgf19 Erbb4 Tnks2 Them4 Irs1 Mta1 Frs2 Mta2 Gatad2a LOC100910717 Maf1 Gatad2b Akt2 Eed Pik3r1 Pik3r2 Rbbp7 Mecom Cd28 Icos Casp9 Csnk2b Mapkap1 Psmc5 Pik3cb Psma1 Psma4 Psmc1 Ptpn11 Psma3 Psmc4 Psma6 Psme1 Ezh2 Psme2 Rhog Grb2 SUMOYLATION OF TRANSCRIPTION FACTORS%REACTOME%R-RNO-3232118.1 SUMOylation of transcription factors Mitf Sumo1 Pias3 Pias4 Ube2i Tfap2c Pias1 Mta1 Tp53bp1 Foxl2 Sumo3 Pias2 M PHASE%REACTOME%R-RNO-68886.1 M Phase Cenpn Zwilch Cenpl Cenpo Dync1li2 Cenpt Cenpu Kif23 Bub3 Bub1 Spdl1 Kntc1 Dync1i2 Mad1l1 LOC100910252 Csnk2a2 Stag1 Cenpk Cenph Cenpi Csnk2a1 Pds5b Pds5a Cenpf Cdca5 Cenpe Rad21 Cenpm Smc1a Stag2 Ahctf1 Smc3 Ndel1 Rcc2 Pafah1b1 Mis12 LOC102555167 Dynll2 Ndc80 Cenpc Cenpa Dync1i1 Birc5 Taok1 Ube2d1 Nup88 RGD1310212 Nup85 Anapc7 Cdc26 Cdc27 Cdc23 Pttg1 Ube2c Anapc16 Cdc16 Nek2l1 Rae1 Anapc4 Anapc2 Anapc1 Kif20a Lpin2 Prkca Lpin3 Lpin1 Nek2 Nup93 Nup98 Rab2a Nup107 Nup210 Anapc11 Nupl2 Anapc15 Anapc10 Nupl1 Fbxo5 Cdca8 Rangap1 Ppp1cc LOC100909468 Aurkb Sec13 Ensa Xpo1 Arpp19 Rab1b Nup205 Rab1a LOC100911204 Spc24 Spc25 Itgb3bp Sgol2 Ppp2r5e Incenp G6pc Nsl1 Nup155 B9d2 Cdc20 Kif2a Kif2c Kif2b Psmb7 Psmb1 Bub1b Kif18a Ppp2r5c Ppp2r5a Ppp2r5b Zwint Dsn1 Mad2l1 Casc5 Nup153 Clasp2 Ercc6l Nuf2 Psma5 Clasp1 Tpr LOC679582 Mapre1 Psma2 Cdc42 Pmf1 Psmd2 Nup54 Psmc2 Ckap5 Pom121 Ska2 Psmd1 Psmd7 Nup62 Sgol1 Zw10 Psmd3 Ska1 Psmd6 Psmc6 Nup43 Psmb10 Nup133 Psmb8 Psmb9 Psmb4 Aaas Psmb11 Psmb5 Psmf1 Psmb6 Psmd4 Psmb2 Psmd5 Npap60 Psmd8 Cep57 Psmd9 Psmb3 Nup35 Psma8 Nup37 Psmd11 LOC691918 Psmd12 Haus3 Psmd13 Ninl Psmd14 Akap9 Ccp110 Psmc3 Ranbp2 Setd8 Tubb5 Ppp2cb Ppp2ca Ywhag Ppp2r1a Prkcb Ywhae Ppp2r1b Mapk1 Prkaca Tubgcp2 Hist1h2bo Dync1h1 Hist1h2bcl1 Cnep1r1 Hist2h3c2 Hist1h2bk Gorasp2 H3f3b Dync1li1 LOC103692716 Numa1 Lemd2 Nek6 Blzf1 Hdac8 Nek7 LOC100909949 Dctn1 LOC100910200 Cntrl H2afx Mcph1 Dctn2 RGD1563307 Hist1h4b Cep76 LOC684841 Hist1h2bh Pcm1 Rb1 Cep78 Ncapg LOC100912290 Hist1h2ail1 Gorasp1 Lemd3 LOC100911033 Hist1h4m LOC102549173 Cep164 Mau2 LOC103690002 Dctn3 Cep41 Ofd1 Lmna LOC100910152 LOC100912338 Vrk2 Hist1h3c Sdccag8 Ncaph2 H2afb3 Hist1h3f Vrk1 Ctdnep1 Prkar2b Cenpj Hist2h4 LOC684819 Hist1h3a Plk4 Smc4 H2afj Hist2h2aa3 Tmpo Hist1h2bq Espl1 Hist2h2aa2 Smc2 LOC100364835 LOC684762 LOC100912076 Tubg2 Csnk2b Haus2 Haus1 Haus5 Alms1 Haus4 Odf2 Tubb4a Cdk1 Lmnb1 Ncapg2 Ssna1 Tubg1 Cep63 Csnk1d Psmc5 Cep131 Psma1 Tuba4a Psma4 Cep250 Psmc1 Cep135 Psma3 Csnk1e Psmc4 Cdk5rap2 Psma6 Psme1 Nme7 Tubgcp5 Hist1h2bg Pcnt Tubgcp6 Psme2 Cep72 Tubgcp3 LOC680097 Sfi1 Tubgcp4 LOC684797 Cep70 Actr1a LOC100912418 Hist1h2ba LOC100363782 Mzt1 Hist3h2bb Nedd1 Mzt2b ACTIVATION OF BID AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%R-RNO-75108.1 Activation of BID and translocation to mitochondria Gzmbl1 Gzmc LOC100911163 Gzmbl2 Gzmbl3 Nmt1 Bid Gzmb Casp8 LOC691695 FGFR1C AND KLOTHO LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 66%10145295 FGFR1c and Klotho ligand binding and activation Fgf23 Fgfr1 INTRAFLAGELLAR TRANSPORT%REACTOME%R-RNO-5620924.1 Intraflagellar transport Kif3c Ift81 Kif3b Kifap3 Ift122 Wdr19 Ttc21b Ift46 Ift43 Wdr60 Kif17 Tnpo1 Dynlrb2 Ift74 Ttc26 Wdr35 Dynlrb1 Kif3a Tcte3 Ift88 Dync2li1 Dynll2 Ift52 Hspb11 Ift57 Traf3ip1 Ift27 Ift22 Trip11 Ift20 Cluap1 Tctex1d1 Ift140 Tctex1d2 Ttc30b Ift80 BETA OXIDATION OF PALMITOYL-COA TO MYRISTOYL-COA%REACTOME DATABASE ID RELEASE 66%10144934 Beta oxidation of palmitoyl-CoA to myristoyl-CoA Hadha Hadhb Acadvl SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE%REACTOME DATABASE ID RELEASE 66%10145902 Synthesis of PIPs at the early endosome membrane Pi4k2a Pik3c3 Mtmr2 Fig4 Pik3r4 Inpp4a Mtmr4 Inpp4b Vac14 Mtmr12 Inpp5f Pikfyve Pik3c2a Pi4k2b RNA POLYMERASE II TRANSCRIPTION ELONGATION%REACTOME%R-RNO-75955.1 RNA Polymerase II Transcription Elongation Gtf2h1 Gtf2h2 Mnat1 RGD1565904 Leo1 Polr2g Polr2h Polr2e Polr2f Supt16h Polr2j Polr2k Polr2d Ctr9 Polr2i Polr2b Polr2c Polr2a Wdr61 Gtf2f1 LOC100912534 Gtf2f2 Ell Tceb2 Tceb1 Iws1 Tcea1 Ccnh Gtf2h3 Paf1 Gtf2h5 Gtf2h4 Cdc73 Aff4 Ccnt2 Tceb3 Rtf1 Cdk9 Supt6h Eaf1 Eaf2 Ercc3 Ccnk Supt5h LOC100911822 Mllt1 Ercc2 Ncbp2 Ncbp1 Supt4h1 Cdk7 Nelfe Nelfa Nelfb Ssrp1 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE%REACTOME DATABASE ID RELEASE 66%10145157 Toll Like Receptor 5 (TLR5) Cascade Map2k7 Ripk2 Map2k6 Ager Dusp3 Map2k4 Map3k8 Dusp4 Peli3 Nfkbib LOC100912399 Peli2 Map3k1 Traf6 Cul1 Vrk3 Rps6ka2 Rps6ka1 App Rps6ka3 Rps6ka5 LOC100912585 Tab1 Dusp7 Dusp6 Rela Atf1 Atf2 Map3k7 Peli1 Irak2 Nfkbia LOC100910771 Ube2n Jun Ppp2cb Ppp2ca Skp1 Ppp2r1a Nfkb2 Nfkb1 Mapk9 Mapk8 Fos S100b Mapk7 Dhx9 Fbxw11 Chuk Ppp2r1b Ecsit Mapkapk3 Btrc Mapkapk2 Mapk1 Nkiras1 LOC100362142 Nod1 Nod2 Nkiras2 Creb1 Tab2 Tab3 LOC100912618 Ube2v1 Ikbkb Mapk14 Myd88 Tnip2 Mapk11 Mapk10 GLUCOCORTICOID BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 66%10145323 Glucocorticoid biosynthesis Pomc Hsd3b1 Hsd3b Hsd3b2 LOC100911154 Hsd11b2 Cyp21a1 Cyp11b2 REACTIONS SPECIFIC TO THE COMPLEX N-GLYCAN SYNTHESIS PATHWAY%REACTOME DATABASE ID RELEASE 66%10145779 Reactions specific to the complex N-glycan synthesis pathway Mgat2 Chst8 Lhb Man2a1 Fut8 Man2a2 Chst10 Cga SIGNALING BY INTERLEUKINS%REACTOME DATABASE ID RELEASE 66%10145163 Signaling by Interleukins Il21r Il21 Rbx1 Socs5 Socs3 Vamp2 Casp3 Fyn Stat6 Il1rl2 Il36rn Il1f10 Il1rap Il36b Il36a Sqstm1 Stx4 Ube2n Ptk2b Il1rl1 Brwd1 Pik3cd Irak4 Crk Stx1a Lyn Crkl Yes1 Hck Rapgef1 Syk LOC100911248 Map2k7 Ripk2 Tbk1 Map2k6 Ager Dusp3 Map2k4 Map3k8 Dusp4 Peli3 Nfkbib Peli2 Traf6 Cul1 Vrk3 Rps6ka2 Rps6ka1 App Rps6ka3 Il33 Canx Rps6ka5 LOC100912585 Tab1 Dusp7 Dusp6 Rela Atf1 Atf2 Map3k7 Peli1 Irak2 Nfkbia LOC100910771 Il2rg G6pc Psmb7 Psmb1 Vav1 Il9r Il15 Il9 P4hb Psma5 Tollip Sos2 Psma2 Il10ra Il10 Il5 Psmd2 Il2 Ptpn6 Psmc2 Il2ra Csf2 Psmd1 Il3ra Psmd7 Psmd3 Il2rb Psmd6 Psmc6 Csf2ra Csf2rb Psmb10 Psmb8 Psmb9 Psmb4 Psmb11 Psmb5 Psmf1 Il5ra Psmb6 Psmd4 Psmb2 Psmd5 Psmd8 Psmd9 Psmb3 Psma8 Psmd11 Psmd12 Psmd13 Psmd14 Csf1 Psmc3 Il1b Pik3r3 Inpp5d Jun Ppp2cb Ppp2ca Skp1 Ppp2r1a Ywhaz Nfkb2 Nfkb1 Mapk9 Mapk8 Fos S100b Mapk7 Dhx9 Fbxw11 Chuk Ppp2r1b Mapkapk3 Btrc Mapkapk2 Mapk1 Nkiras1 Prkaca LOC100362142 Nod1 Nod2 Nkiras2 Creb1 Tab2 Tab3 LOC100912618 Ube2v1 Ikbkb Mapk14 Myd88 Tnip2 Mapk11 Mapk10 Stat5a Jak3 Il22 Il24 Il19 Stat1 Il22ra1 Jak1 Stat2 Stat3 Il10rb Hsp90b1 Cd4 Hist2h3c2 Irs2 Cbl Smarca4 Il13ra1 Clcf1 Il13ra2 Il12b Il31ra Irak3 Il12a LOC100360218 Il22ra2 Cntf Il20ra Irs1 Csf3 Il20rb Il23r Il1r1 Tyk2 Ifnl3 Crlf2 Il20 Ebi3 Ifnlr1 Il4r Il17c Il1rapl1 Map3k3 Il17a Il23a Crlf1 LOC684841 Il4 Pik3r1 Il6 Lif Il6st Pik3r2 Stxbp2 Csf1r Ptprz1 Hist1h2ail1 Il13 Txlna LOC102549173 Il11ra1 Lifr Il18r1 Il12rb1 Hist1h3c Il12rb2 Csf3r Hist1h3f Il17rc Il11 Stx3 Il18 LOC684819 Hist1h3a Il16 Ctf1 Il1a Casp1 Il25 Osmr Il17rb Il17ra Il17re Il27ra LOC684762 Socs1 Cntfr Osm Psmc5 Pik3cb Psma1 Psma4 Ptpn11 Psmc1 Tec Psma3 Psmc4 Psma6 Psme1 Psme2 Sos1 Vamp7 Shc1 Grb2 DETOXIFICATION OF REACTIVE OXYGEN SPECIES%REACTOME%R-RNO-3299685.1 Detoxification of Reactive Oxygen Species Txn2 Gstp1 LOC100910067 Cat Sod1 Sod3 Txnrd2 Nudt2 Nox4 Ero1l Sod2 Txnrd1 Gsr Prdx1 P4hb Gpx8 Gpx7 Gpx6 Ncf1 Ncf4 Prdx3 Txn1 Cybb Cyba Ccs Prdx6 PLASMA LIPOPROTEIN CLEARANCE%REACTOME%R-RNO-8964043.1 Plasma lipoprotein clearance Nr1h3 Nr1h2 Ldlr Cltc Scarb1 Cubn Amn Clta Hdlbp Apoa1 Ap2s1 Ap2a1 Ap2m1 Ap2a2 Pcsk9 Apobr Vldlr Npc1 Nceh1 Lipa Mylip Soat1 Soat2 Apob Apoe Apoc1 LOC100910181 Apoc4 Ldlrap1 PEROXISOMAL LIPID METABOLISM%REACTOME%R-RNO-390918.1 Peroxisomal lipid metabolism Amacr Phyh Nudt7 Abcd1 Acot6 Acot4 Acot8 Acox1 Ehhadh Eci3 Hsd17b4 Mlycd Crot Acoxl Acaa1a Acaa1b Acox3 Acox2 Hao2 Aldh3a2 Slc27a2 LOC100910957 Slc25a17 Crat Acbd5 Hacl1 Acbd4 GAP JUNCTION ASSEMBLY%REACTOME%R-RNO-190861.1 Gap junction assembly Gja1 Gja5 Gjd4 Gja3 Gja8 Gja4 Gjb6 Gjb2 Gja10 Gjd2 Gjb3 Gjb4 Gjc1 Gjc2 Gjb1 DNA DAMAGE RECOGNITION IN GG-NER%REACTOME DATABASE ID RELEASE 66%10146144 DNA Damage Recognition in GG-NER Ddb2 Yy1 Ddb1 Rbx1 Actr8 Cops4 Cops6 Actl6a Mcrs1 Cops3 Ino80e Cops8 Ino80d Nfrkb Cops2 Actb Parp2 Parp1 Rad23a Rad23b Cops7b Ino80 Cops7a Cul4b Cul4a Xpc Ruvbl1 Ino80b Ino80c MITOTIC METAPHASE AND ANAPHASE%REACTOME DATABASE ID RELEASE 66%10145109 Mitotic Metaphase and Anaphase Cenpn Psmc6 Zwilch Cenpl Nup43 Cenpo Psmb10 Nup133 Dync1li2 Psmb8 Cenpt Psmb9 Cenpu Psmb4 Psmb11 Bub3 Bub1 Psmb5 Psmf1 Psmb6 Spdl1 Psmd4 Kntc1 Psmb2 Dync1i2 Psmd5 LOC100910252 Psmd8 Mad1l1 Stag1 Psmd9 Psmb3 Psma8 Cenpk Cenph Nup37 Cenpi Psmd11 Psmd12 Pds5b Pds5a Cenpf Cdca5 Psmd13 Rad21 Cenpe Psmd14 Smc1a Cenpm Stag2 Smc3 Ahctf1 Ndel1 Rcc2 Pafah1b1 Mis12 Dynll2 Psmc3 Ndc80 Cenpc Cenpa Dync1i1 Ranbp2 Birc5 Taok1 Ube2d1 Ppp2cb Ppp2ca Ppp2r1a Nup85 Anapc7 Cdc26 Cdc27 Cdc23 Pttg1 Ube2c Anapc16 Ppp2r1b Cdc16 Anapc4 Anapc2 Anapc1 Nup98 Nup107 Anapc11 Anapc15 Anapc10 Fbxo5 Dync1h1 Cdca8 Dync1li1 Rangap1 Ppp1cc LOC100909468 Aurkb Sec13 Xpo1 LOC100911204 Spc24 Spc25 Hdac8 Itgb3bp Sgol2 Ppp2r5e Incenp G6pc Nsl1 B9d2 Cdc20 Kif2a Kif2c Kif2b Vrk2 Psmb7 Bub1b Psmb1 Kif18a Ppp2r5c Vrk1 Ppp2r5a Ppp2r5b Zwint Dsn1 Espl1 Mad2l1 Casc5 Clasp2 Ercc6l Psma5 Nuf2 Clasp1 LOC679582 Psma2 Mapre1 Psmc5 Psma1 Pmf1 Psmd2 Psma4 Psmc1 Psma3 Psmc4 Psma6 Ckap5 Psmc2 Psme1 Ska2 Psme2 Psmd1 Psmd7 Sgol1 Zw10 Psmd3 Ska1 Psmd6 POST NMDA RECEPTOR ACTIVATION EVENTS%REACTOME%R-RNO-438064.1 Post NMDA receptor activation events Grin2d Rras Camk2g Grin2b Grin1 Nefl Rasgrf1 Raf1 Dlg1 Dlg2 Dlg3 Camk2d Actn2 Camk2a Rps6ka2 Rps6ka1 Lrrc7 Rps6ka3 Adcy3 Adcy8 Camkk1 Pdpk1 Mapk1 Creb1 Rps6ka6 Hras Camk4 Dlg4 MAP KINASE ACTIVATION%REACTOME DATABASE ID RELEASE 66%10145160 MAP kinase activation Map2k7 Ripk2 Map2k6 Dusp3 Map2k4 Map3k8 Dusp4 Traf6 Cul1 Vrk3 Rps6ka2 Rps6ka1 Rps6ka3 Rps6ka5 LOC100912585 Tab1 Dusp7 Dusp6 Atf1 Atf2 Map3k7 Irak2 LOC100910771 Ube2n Jun Ppp2cb Ppp2ca Skp1 Ppp2r1a Nfkb1 Mapk9 Mapk8 Fos Mapk7 Fbxw11 Chuk Ppp2r1b Mapkapk3 Btrc Mapkapk2 Mapk1 LOC100362142 Nod1 Nod2 Creb1 Tab2 Tab3 LOC100912618 Ube2v1 Ikbkb Mapk14 Tnip2 Mapk11 Mapk10 NUCLEOBASE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 66%10144842 Nucleobase biosynthesis Impdh1 Impdh2 Cad Pfas Ppat LOC100912917 Adss Gmps Lhpp Atic Gart Adsl Umps Adssl1 Dhodh Paics MITOCHONDRIAL TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 66%10145689 Mitochondrial tRNA aminoacylation Ppa2 PI3K AKT ACTIVATION%REACTOME DATABASE ID RELEASE 66%10145352 PI3K AKT activation Pik3cb Ntrk1 Ngf Rhoa Pik3r1 Irs2 Pik3r2 Irs1 PTK6 REGULATES PROTEINS INVOLVED IN RNA PROCESSING%REACTOME DATABASE ID RELEASE 66%10146207 PTK6 Regulates Proteins Involved in RNA Processing Khdrbs2 Khdrbs1 Ptk6 Khdrbs3 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE%REACTOME%R-RNO-204998.1 Cell death signalling via NRAGE, NRIF and NADE Aph1b Psenen Aph1a Ngfr LOC100911293 Psen2 Psen1 Traf6 Ncstn Rac1 Casp3 Sqstm1 Itgb3bp Arhgef6 Arhgef5 Arhgef39 Arhgef7 Arhgef37 Arhgef38 Arhgef33 Prex1 Itsn1 Arhgef2 LOC102556447 Arhgef4 Arhgef3 Plekhg5 Arhgef19 Arhgef18 Plekhg2 Ngf Kalrn Bcl2l11 LOC100912512 Vav2 Gna13 Casp2 Vav1 Arhgef11 Akap13 Ywhae Arhgef16 Arhgef15 Bad Net1 Ect2 Arhgef26 Fgd2 Mapk8 Mcf2l Tiam1 Tiam2 Vav3 Fgd3 Sos2 Ngef Sos1 Ngfrap1 SELENOAMINO ACID METABOLISM%REACTOME%R-RNO-2408522.1 Selenoamino acid metabolism Txnrd1 Scly Mat1a CELL CYCLE CHECKPOINTS%REACTOME DATABASE ID RELEASE 66%10144741 Cell Cycle Checkpoints Cenpn Zwilch Rfc2 Cenpl Cenpo Dync1li2 Mdm2 Cenpt Cenpu Bub3 Bub1 Spdl1 Kntc1 Dync1i2 Mad1l1 Cenpk Cenph Cenpi Pias4 Cenpf Cenpe Cenpm Uimc1 Ahctf1 Ndel1 Rcc2 Pafah1b1 Sumo1 Rpa3 Mis12 Dynll2 Brca1 Ndc80 Blm Cenpc Mdc1 Ube2v2 Cenpa Dync1i1 Ube2n Rfc5 Rfc4 Birc5 Rfc3 Rfwd2 Taok1 Ube2d1 Tp53bp1 Herc2 Rpa1 Rpa2 Nup85 Anapc7 Cdc26 Cdc27 Cdc23 Ube2c Cdkn1a Cdkn1b Anapc16 Cdc16 Anapc4 Anapc2 Anapc1 Slc25a16 Nup98 Nup107 Anapc11 Anapc15 Anapc10 Cdca8 Cdc25c Rangap1 Ppp1cc LOC100909468 Aurkb Sec13 Xpo1 LOC100911204 Spc24 Spc25 Itgb3bp Sgol2 Ppp2r5e Incenp G6pc Nsl1 B9d2 Cdc20 Kif2a Kif2c Kif2b Psmb7 Bub1b Psmb1 Kif18a Ppp2r5c Ppp2r5a Ppp2r5b Zwint Dsn1 Mad2l1 Casc5 Clasp2 Ercc6l Nuf2 Psma5 Clasp1 LOC679582 Mapre1 Psma2 Pmf1 Psmd2 Psmc2 Ckap5 Ska2 Psmd1 Psmd7 Sgol1 Zw10 Psmd3 Ska1 Psmd6 Rhno1 Bard1 Psmc6 Wrn Nup43 Psmb10 Topbp1 Nup133 Rbbp8 Rmi1 Rmi2 Psmb8 Psmb9 Psmb4 Psmb11 Psmb5 Psmf1 Psmb6 Rad50 Bre Psmd4 Psmb2 Psmd5 Psmd8 Psmd9 Psmb3 Brcc3 Psma8 Nup37 Psmd11 Psmd12 Ccna2 Ccna1 Ccne2 Psmd13 Psmd14 Ccne1 Phf20 Atm Mcm2 Atrip Mcm4 Mcm3 Cdk2 Mcm5 Clspn Mcm6 Mcm10 Rad1 Psmc3 Atr Mcm8 Mcm7 Rad17 Orc4 Orc5 Orc6 Orc1 Orc2 Ranbp2 Orc3 Cdc7 Rad9a Cdc6 Nbn Rad9b Mre11a Cdc45 Hus1 Babam1 Ppp2cb Ywhah Ppp2ca Ywhag Ppp2r1a Sfn Ywhaz Ywhab Ywhaq Ywhae Ppp2r1b Hist1h2bo Dync1h1 Hist1h2bcl1 Hist1h2bk Dync1li1 Zfp385a LOC100910200 Whsc1 H2afx Hist1h4b Rnf8 Hist1h2bh LOC100912290 LOC686349 Hist1h4m LOC100912338 Hist2h4 Hist1h2bq LOC100364835 Fam175a LOC100910954 Cdk1 Mdm4 Chek2 Gtse1 Psmc5 Psma1 Psma4 Cdc25a Psmc1 Wee1 Psma3 Pkmyt1 Psmc4 Psma6 Psme1 Hist1h2bg Psme2 LOC680097 LOC684797 LOC100912418 Hist1h2ba Hist3h2bb NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC)%REACTOME%R-RNO-975957.1 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Rnps1 LOC100912571 Magohb Rps20 Rps27l Rbm8a LOC100360573 Eif4g1 Rps4x LOC100359951 LOC100359593 Rpl30 Rpl4 LOC100359503 Rplp0 LOC100362640 Rpl6 Rpl13a Rpl26 Rps3 LOC100363800 Rps15a LOC685963 Rpl32 Rps2 Rps13 Gspt1 Rps12 Pnrc2 Pabpc2 Pabpc6 LOC100911372 Rplp1 LOC100361854 Rpl39 LOC684988 Rpl38 LOC103689992 Gspt2 Rps5 Rpl22 Rps7 Rpl23 Rpl10l Rps6 Smg8 Upf1 Rpl15 RGD1563300 Rpl19 Rpl10a Smg9 LOC100362830 LOC690468 Rpl29 LOC100363012 Smg7 Smg6 LOC680559 Smg5 Rpl39l LOC100362149 Upf3b Rpl41 LOC100912182 LOC100360057 Upf3a Rpl36al Etf1 Rpl13 Rpl3l Rpl36a Dcp1a Rps16 Ppp2ca Ppp2r1a LOC100911431 Pabpc1 Rps18 LOC100360679 Rps15 Magoh Rps3a Ncbp2 Ncbp1 Eif4a3 Ppp2r2a INTERLEUKIN-18 SIGNALING%REACTOME%R-RNO-9012546.1 Interleukin-18 signaling Il18 Il18r1 FRS-MEDIATED FGFR2 SIGNALING%REACTOME DATABASE ID RELEASE 66%10146103 FRS-mediated FGFR2 signaling Kras Frs3 Fgf23 Fgf22 Fgf4 Fgf1 Fgf3 Fgf6 Fgf5 Fgf20 Fgf16 Fgf17 Fgf10 Fgf9 Fgfr2 Fgf7 Fgf2 Fgf8 Fgfr3 Fgfr1 Fgfr4 Ptpn11 Fgf19 Hras Nras Sos1 Frs2 Grb2 BASE-EXCISION REPAIR, AP SITE FORMATION%REACTOME%R-RNO-73929.1 Base-Excision Repair, AP Site Formation Tdg Mpg Neil1 Ogg1 Neil2 Mbd4 Smug1 Ung Nthl1 Mutyh RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER%REACTOME DATABASE ID RELEASE 66%10144947 RNA Polymerase III Transcription Initiation From Type 2 Promoter Bdp1 Polr3d Polr3c Polr3a Polr3e RGD1565904 Polr3b Polr3h Polr2h Polr3k Polr2e Polr2f Polr3g Polr1c Polr2k Polr3f Gtf3c6 Gtf3c5 Gtf3c1 LOC100912534 Gtf3c3 Gtf3c4 Polr3gl Brf1 Tbp CYP2E1 REACTIONS%REACTOME%R-RNO-211999.1 CYP2E1 reactions Cyp2b2 LOC100910127 Cyp2s1 Cyp2b1 LOC100361547 Cyp2b3 Cyp2d5 Cyp2b21 LOC100911763 Cyp2c7 Cyp2b15 Cyp2e1 Cyp2b12 Cyp2d4 Cyp2f4 Cyp2d2 LOC100360055 Cyp2d3 Cyp2c6v1 TRANSLATION INITIATION COMPLEX FORMATION%REACTOME DATABASE ID RELEASE 66%10145076 Translation initiation complex formation LOC100912571 Eif3l Eif2s3 Eif3m Eif3j Eif3k Rps20 Rps27l Eif3e Eif3f Eif3b Eif3a Eif3d Eif3c LOC100360573 Eif2s1 Eif2s2 Eif4g1 Rps4x LOC100359951 LOC100359593 LOC100359503 LOC100362640 Rps3 Rps15a Rps2 Rps13 Rps12 Pabpc2 Pabpc6 LOC100911372 LOC100361854 LOC684988 LOC103689992 Rps5 Rps7 Rps6 Eif3g Eif3h Eif4a2 LOC100362830 Eif1ax Eif4a1 LOC100363012 LOC680559 LOC100911110 LOC100362149 Rps16 LOC100911431 Pabpc1 Rps18 LOC100360679 Rps15 Eif4h Eif4b Rps3a UNBLOCKING OF NMDA RECEPTORS, GLUTAMATE BINDING AND ACTIVATION%REACTOME%R-RNO-438066.1 Unblocking of NMDA receptors, glutamate binding and activation Grin2d Camk2g Grin2b Grin1 Nefl Dlg1 Gria3 Dlg2 Gria4 Dlg3 Camk2d Actn2 Camk2a Lrrc7 Dlg4 CAMK IV-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%R-RNO-111932.1 CaMK IV-mediated phosphorylation of CREB Camk4 LYSOSPHINGOLIPID AND LPA RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145608 Lysosphingolipid and LPA receptors Lppr1 Lppr4 Lppr5 Lppr2 Lppr3 Lpar5 S1pr1 S1pr5 S1pr4 S1pr3 Lpar1 Lpar3 Lpar2 S1pr2 METABOLISM OF INGESTED SEMET, SEC, MESEC INTO H2SE%REACTOME%R-RNO-2408508.1 Metabolism of ingested SeMet, Sec, MeSec into H2Se Scly Mat1a GLYCOSAMINOGLYCAN METABOLISM%REACTOME%R-RNO-1630316.1 Glycosaminoglycan metabolism Cd44 Lyve1 Has1 Has2 B3gat1 B3gat3 B3gat2 Hyal1 Hyal2 Chp1 Sdc2 Sdc3 Sdc4 Fmod Hs2st1 Ncan Hexb Hexa Chst7 Chst9 Slc9a1 Chst5 LOC102550316 Chst3 Chst2 Chst1 B3gnt4 B3gnt7 B3gnt1 B3gnt2 B3gnt3 Gpc6 Chpf2 Gpc4 Gpc2 Ndst1 Ndst2 Ndst3 Ndst4 Ogn Glb1 St3gal2 St3gal3 Slc26a2 Slc26a1 St3gal1 Gpc1 St3gal4 St3gal6 B3galt6 Slc35b2 Kera Slc35b3 Prelp LOC100911750 Cspg5 Cspg4 Acan Dsel Bcan Chsy1 LOC100910284 B4galt1 Ext1 Ext2 B4galt3 B4galt2 B4galt6 B4galt7 B4galt4 B4galt5 Hs3st3b1 Naglu Cemip Agrn Stab2 Xylt2 Chst12 Chst11 Lum Dcn Csgalnact1 Csgalnact2 Hs6st2 Chst13 Papss2 Papss1 Hs6st1 Idua Ust Chst15 Chst14 Vcan Hs3st3a1 Omd Dse Glb1l Arsb LOC100910891 Slc35d2 Gusb Hpse Hs3st5 Chpf Hs3st2 Hs3st1 Hs3st6 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 66%10144983 Resolution of AP sites via the multiple-nucleotide patch replacement pathway Rfc1 Rfc2 Parp2 Rpa3 Pole2 Parp1 Pole4 LOC100911727 Pole Polb Pold2 Pcna Pold1 Pold4 Rpa1 Rpa2 Fen1 Adprhl2 Parg Rfc5 Apex1 Rfc4 Rfc3 Lig1 IGF1R SIGNALING CASCADE%REACTOME%R-RNO-2428924.1 IGF1R signaling cascade Pik3r1 Pik3r2 Fgf23 Fgf22 Fgf4 Fgf1 Fgf3 Tlr9 Fgf6 Fgf5 Fgf20 Gab1 Pde3b Igf2 Igf1 Fgf16 Pik3c3 Fgf17 Irs2 Fgf10 Fgf9 Fgfr2 Fgf7 Fgf2 Fgf8 Pik3r4 Fgfr3 Trib3 Pdpk1 Fgfr1 Fgfr4 Pik3cb Ptpn11 Fgf19 Them4 Irs1 Frs2 Sos1 Shc1 Akt2 Grb2 CELLULAR RESPONSES TO EXTERNAL STIMULI%REACTOME%R-RNO-8953897.1 Cellular responses to external stimuli Hif1an Dync1li2 Mdm2 Vhl Rbx1 Dync1i2 Chmp4bl1 Rpa3 Ncf1 Ncf4 Cited2 Dynll2 Mapkapk5 Atg12 Map1lc3a Dync1i1 Gabarap Ube2d1 Cdk4 Nup88 Rpa1 Rpa2 Ube2d3 Chmp7 Nup85 Chmp6 Chmp3 Anapc7 Cdc26 Cdc27 Cdc23 Gabarapl2 Ube2c Cdkn1a Cdkn1b Anapc16 Cdc16 Rae1 Anapc4 Anapc2 Anapc1 Becn1 Map2k7 Nup93 Dnaja2 Camk2g Asf1a Map2k6 Dnajb6 Dnaja4 Nup98 Ets1 Map2k4 l7Rn6 Nup107 Ep400 Ets2 Tnik Fkbp5 LOC100911837 LOC100910067 Sod1 Camk2d Sod3 Mink1 Camk2a Nup210 Map3k5 Rps6ka2 Txnrd2 Uvrag Rps6ka1 Nudt2 Atg16l1 Hspa14 Wipi1 Atg7 Mtmr14 Rps6ka3 Hspa13 Wipi2 Atg13 Nox4 Atg14 Erf LOC100912585 Atg10 Ubn1 Ambra1 Nupl2 Anapc11 Dnajc7 Cabin1 Anapc15 Mt3 Hdac6 Atg3 Ccar2 Nupl1 Anapc10 Hira Fzr1 Hsph1 Hspa12b Hspa12a Nup205 G6pc Nup155 Psmb7 Psmb1 Sod2 Capzb Mtmr3 Nup153 P4hb Psma5 Pik3c3 Tpr Pik3r4 Psma2 Psmd2 Nup54 Psmc2 Pom121 Psmd1 Psmd7 Nup62 Prdx6 Psmd3 Psmd6 Psmc6 Nup43 Psmb10 Nup133 Psmb8 Psmb9 Psmb4 Aaas Psmb11 Psmb5 Psmf1 Psmb6 Rad50 Psmd4 Psmb2 Psmd5 Npap60 Psmd8 Psmd9 Psmb3 Nup35 Psma8 Nup37 Psmd11 Psmd12 Ccna2 Ccna1 Ccne2 Txnrd1 Psmd13 Psmd14 Ccne1 RragB Prkab1 Prkab2 Atm Gsr Cdk2 Egln2 Tceb2 Tceb1 Cul2 Hif1a Limd1 Psmc3 Atr Epas1 Hif3a Egln3 Ajuba Ranbp2 Nbn Mre11a Hsbp1 Dnajb1 Cryab Hsf1 Hspb8 Hspa1l Hsp90ab1 Akt1s1 Hspa2 Cat Jun Ero1l Ywhae Phc1 Phc2 Bag1 Mtor Bag2 Prdx1 Bag4 Mapk9 Bag5 Mapk8 Rheb Prkag3 Gpx8 Fos Gpx7 Rptor Bag3 Lamtor4 Mapk7 Gpx6 Hspa9 Tsc1 Lamtor5 Hspa5 Capza2 Txn1 Prdx3 Capza3 Stip1 Mlst8 Id1 Mapkapk3 Prkaa1 Map4k4 Tsc2 Rraga Hspa4 Mapkapk2 Ccs Mapk1 Prkaa2 Rragc Rb1cc1 Atg101 Rragd Atg4c Slc38a9 Atg4d Gabarapl1 Atg9a Atg9b Wdr45b Mapk14 Mapk11 Mapk10 Chmp2b Vcp Chmp2a Ulk1 Actr10 Lamtor3 Chmp4b Chmp4c Hist1h2bo Dync1h1 Tinf2 Scmh1 Hist1h2bcl1 Hist2h3c2 Cbx4 Hist1h2bk Cbx2 Lamtor2 H3f3b Cbx8 Lamtor1 Cbx6 Bmi1 Dync1li1 Rnf2 Kdm6b LOC103692716 Ring1 Ptges3 Cybb Cyba Phc3 Ptges3l1 Dctn5 Dctn6 Cdkn2b Terf2ip Fkbp4 Crebbp Cdkn2c Dctn4 Pgr Cdk6 Eed Dctn1 LOC100910200 Txn2 H2afx Dctn2 Hist1h4b Gstp1 LOC684841 Hist1h2bh Acd LOC100912290 Rbbp7 Pot1b Hist1h2ail1 Hist1h4m LOC102549173 LOC103690002 Dctn3 Ehmt2 LOC100910152 Pot1 Ehmt1 LOC100912338 Hist1h3c H2afb3 Hist1h3f Hist2h4 LOC684819 Hist1h3a H2afj Hist2h2aa3 Hist1h2bq Hist2h2aa2 LOC100364835 LOC684762 Terf1 Terf2 LOC100910954 Arnt Mdm4 Psmc5 Psma1 Psma4 Psmc1 Psma3 Psmc4 Psma6 Psme1 Hist1h2bg Psme2 Ezh2 LOC680097 LOC684797 Actr1a LOC100912418 Hist1h2ba Hist3h2bb CHYLOMICRON CLEARANCE%REACTOME%R-RNO-8964026.1 Chylomicron clearance Apob Apoe Ldlrap1 Ldlr HIGHLY SODIUM PERMEABLE ACETYLCHOLINE NICOTINIC RECEPTORS%REACTOME%R-RNO-629587.1 Highly sodium permeable acetylcholine nicotinic receptors Chrnb4 Chrna4 Chrnb2 Chrne Chrnd Chrna3 NEGATIVE REGULATION OF MAPK PATHWAY%REACTOME%R-RNO-5675221.1 Negative regulation of MAPK pathway Dusp16 Kras Ksr1 Ppp2r5e Dusp4 Raf1 Ppp5c Dusp10 Paqr3 Ppp2r5c Ppp2cb Ppp2r5a Ppp2ca Ppp2r1a Ppp2r5b Dusp7 Dusp6 Ywhab Pbp2 Dusp9 Dusp2 Dusp5 Pebp1 Ppp2r1b Dusp1 LOC100909468 Mark3 Araf Mapk1 Hras Nras Map2k2 SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE%REACTOME DATABASE ID RELEASE 66%10145899 Synthesis of PIPs at the late endosome membrane Vac14 Pik3c3 Mtmr7 Mtmr2 Fig4 Pikfyve Pik3c2a Pik3r4 Mtmr4 ACETYLCHOLINE REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 66%10145585 Acetylcholine regulates insulin secretion Plcb1 Marcks Prkca Plcb3 Gnaq Gna11 Gna14 Gna15 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS%REACTOME%R-RNO-674695.1 RNA Polymerase II Pre-transcription Events Gtf2h1 Gtf2h2 Mnat1 RGD1565904 Leo1 Polr2g Polr2h Polr2e Supt16h Polr2f Polr2j Polr2k Polr2d Ctr9 Polr2i Polr2b Polr2c Polr2a Wdr61 LOC100912534 Gtf2f1 Gtf2f2 Ell Gtf2a1 Tceb2 Tceb1 Atp5c1 Iws1 Tcea1 Taf7l Ccnh Gtf2h3 Paf1 Gtf2h5 Tbp Gtf2h4 Cdc73 Ccnt2 Aff4 Gtf2e1 Tceb3 Gtf2e2 Rtf1 Cdk9 Supt6h Eaf1 Taf11 Eaf2 Ercc3 Taf15 Taf2 Taf13 Taf9 Ccnk Taf12 LOC100911822 Mllt1 Supt5h Taf7 Taf4b Ercc2 Taf3 Taf6 Taf5 Ncbp2 Ncbp1 Supt4h1 Cdk7 Nelfe Taf10 Nelfa Nelfb Gtf2b Ssrp1 Taf9b REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA)%REACTOME DATABASE ID RELEASE 66%10145590 Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) Carm1 Ncoa2 Helz2 Sin3a Tbl1xr1 Sin3b Med1 Rxra Hdac3 Ncor2 Tgs1 Fabp1 Smarcd3 Ncoa6 Ppara Tbl1x Crebbp Ncoa1 CONJUGATION OF SALICYLATE WITH GLYCINE%REACTOME%R-RNO-177128.1 Conjugation of salicylate with glycine Glyatl3 Glyat CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY%REACTOME DATABASE ID RELEASE 66%10145212 Cyclin A:Cdk2-associated events at S phase entry Psmc6 Psmb10 Psmb8 Psmb9 Psmb4 Psmb5 Psmf1 Psmb6 Mnat1 Psmd4 Psmb2 Cul1 Psmd5 Ptk6 Psmd8 Psmd9 Psmb3 Psmd11 Psmd12 Ccna2 Ccna1 Ccne2 Psmd13 Psmd14 Ccne1 Fzr1 Cdk2 Cks1l Cables1 Psmc3 Ccnh Cks1b Akt2 G6pc Rb1 Cdk4 Akt1 Psmb7 Psmb1 Ccnd1 Skp1 Psma5 Skp2 Cdkn1a Cdk7 Cdkn1b Psma2 Psmc5 Akt3 Psmd2 Psma1 Cdc25b Psma4 Psmc1 Cdc25a Wee1 Psma3 Psmc4 Psmc2 Psma6 Psme1 Psmd1 Psme2 Psmd7 Psmd3 Psmd6 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 66%10145513 Nuclear Receptor transcription pathway Nr1d1 Nr1h4 Nr1d2 Nr1h3 Nr1h2 Nrbf2 Vdr Med1 Nr5a1 Rarg Rxra Rora Esr2 Nr1i2 Pparg Nr2c2ap Hnf4a Hnf4g Esrrg Ppara Nr4a3 Nr4a1 Nr4a2 LOC100363472 Ppard Nr1i3 Nr0b1 Nr0b2 Nr5a2 Esrra Esrrb Rxrg Nr6a1 Nrbp1 Nr2c2 Nr2c1 Esr1 Rara Rarb Nr2e1 Nr2f6 Nr2f1 Pgr Rorb Nr2e3 Thra Thrb AURKA ACTIVATION BY TPX2%REACTOME%R-RNO-8854518.1 AURKA Activation by TPX2 Dync1i2 Cep57 LOC691918 Haus3 Ninl Aurka Akap9 Ccp110 Dync1h1 Pafah1b1 LOC103692716 Dctn1 Cntrl Dctn2 Cep76 Pcm1 Cep78 LOC100911033 Cep164 Dctn3 Cep41 Ofd1 Sdccag8 Tubb5 Prkar2b Cenpj Ywhag Ppp2r1a Plk4 Ywhae LOC100912076 Tubg2 Haus2 Haus1 Haus5 Tpx2 Alms1 Clasp1 Haus4 Odf2 Tubb4a Cdk1 Nek2l1 Ssna1 Mapre1 Tubg1 Cep63 Prkaca Csnk1d Cep131 Tuba4a Cep250 Cep135 Csnk1e Ckap5 Cdk5rap2 Pcnt Nek2 Cep72 Sfi1 Cep70 Actr1a Nedd1 FATTY ACIDS%REACTOME%R-RNO-211935.1 Fatty acids Cyp2b2 LOC100910127 Cyp4a2 Cyp2b1 Cyp4f39 Cyp4a1 Cyp2b3 Cyp2d5 Cyp2b21 Cyp4f6 Cyp4a8 LOC100911763 Cyp2b15 Cyp2b12 LOC100912391 Cyp2d4 Cyp2f4 Cyp4f17 Cyp2d2 Cyp2j10 LOC100360055 Cyp2d3 Cyp4f18 MITOTIC PROPHASE%REACTOME DATABASE ID RELEASE 66%10145525 Mitotic Prophase Nup93 Nup43 Nup98 Nup133 Nup107 Rab2a Aaas Nup210 Npap60 Nup35 Nup37 Nupl2 Nupl1 Hist1h2bo Hist1h2bcl1 Cnep1r1 Hist2h3c2 Gorasp2 Hist1h2bk H3f3b LOC102555167 Numa1 Ensa Lemd2 Arpp19 Nup205 Nek6 Rab1b Rab1a Ranbp2 Blzf1 Setd8 Nek7 LOC100909949 LOC100910200 Mcph1 H2afx RGD1563307 Hist1h4b LOC684841 Hist1h2bh Rb1 LOC100912290 Nup155 Gorasp1 Hist1h2ail1 Hist1h4m Lemd3 LOC102549173 LOC103690002 Lmna LOC100910152 LOC100912338 Hist1h3c Ncaph2 H2afb3 Hist1h3f Ctdnep1 Nup88 Hist2h4 LOC684819 Hist1h3a Prkcb H2afj Smc4 Tmpo Hist2h2aa3 Hist1h2bq RGD1310212 Hist2h2aa2 Smc2 Nup85 LOC100364835 LOC684762 Nup153 Tpr Cdk1 Lmnb1 Rae1 Ncapg2 Mapk1 Nup54 Lpin2 Lpin3 Prkca Lpin1 Hist1h2bg Pom121 LOC680097 LOC684797 Nup62 LOC100912418 LOC100363782 Hist1h2ba Hist3h2bb THE RETINOID CYCLE IN CONES (DAYLIGHT VISION)%REACTOME DATABASE ID RELEASE 66%10145969 The retinoid cycle in cones (daylight vision) Opn1sw Awat2 Dhrs3 Rlbp1 Opn1mw TERMINATION OF O-GLYCAN BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 66%10145784 Termination of O-glycan biosynthesis St6gal1 St3gal2 Muc13 St6galnac4 St3gal3 Muc1 St6galnac3 Muc15 St3gal1 Muc20 St6galnac2 St3gal4 GLYCOGEN METABOLISM%REACTOME DATABASE ID RELEASE 66%10144770 Glycogen metabolism Phkb Epm2a Phkg1 Pgm2l1 Gaa Agl Ugp2 Pgm2 Pygl Pgm1 Pygm Phkg2 Gyg1 Gys1 Gys2 Ppp1r3c Nhlrc1 Phka1 INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES%REACTOME%R-RNO-499943.1 Interconversion of nucleotide di- and triphosphates Nme2 Txnrd1 Gsr Tyms Dtymk LOC305806 Nme3 Nudt13 Nme1 Ak5 Ak4 Ak6 Ak8 Rrm2b Txn1 Dut Ctps2 Ctps1 Glrx Rrm2 Rrm1 Dctd LOC100360124 LOC100359853 Guk1 N-GLYCAN ANTENNAE ELONGATION%REACTOME DATABASE ID RELEASE 66%10145781 N-Glycan antennae elongation B4galt3 St6gal1 Mgat5 B4galt2 B4galt6 B4galt4 B4galt5 St8sia3 Mgat4b Mgat4a St3gal4 B4galt1 O-LINKED GLYCOSYLATION%REACTOME%R-RNO-5173105.1 O-linked glycosylation Adamts13 Adamts15 Adamts19 Pofut2 Adamts16 Adamts17 Pomk Adamts12 Spon2 Galnt9 LOC102550196 Spon1 Gcnt1 LOC100911750 Large A4gnt Muc13 C1galt1 Gyltl1b Muc15 C1galt1c1 Galnt16 Adamts1 Galnt18 Galnt14 Adamts6 Galnt15 Adamts7 Galnt12 Galnt13 Adamts9 Sspo B3gntl1 Galnt10 Cfp Sema5b Thbs2 Thbs1 B4galt6 Adamtsl2 B4galt5 Adamtsl3 Muc20 Thsd1 Adamtsl4 Dag1 LOC102554393 Sbspon Adamts4 Adamts3 Adamts5 Sema5a B3gnt4 B3gnt7 B3gnt1 B3gnt2 B3gnt3 Adamts14 St6galnac2 B3galnt2 B3gnt6 Pomt2 Thsd7a Galntl5 St6gal1 Pomgnt2 Galnt6 Galnt5 Pomt1 St6galnac4 B3gnt8 St3gal2 Muc1 St6galnac3 St3gal3 B3gnt5 Chst4 St3gal1 Thsd7b Galnt1 Galnt7 St3gal4 Galnt3 Galnt2 Pomgnt1 DNA REPLICATION INITIATION%REACTOME DATABASE ID RELEASE 66%10144718 DNA replication initiation Pole2 Pole4 Prim2 Pola2 Pole Prim1 PURINE SALVAGE%REACTOME DATABASE ID RELEASE 66%10144873 Purine salvage Gmpr2 Ampd1 Gmpr Adal Pnp Ampd3 Dck Dguok Aprt Hprt1 Ada Ampd2 G-PROTEIN BETA:GAMMA SIGNALLING%REACTOME%R-RNO-397795.1 G-protein beta:gamma signalling Pik3r5 Plcb1 Pik3r6 Plcb3 Akt1 Pik3cg Gnb3 Gnb5 Gnb2 Gnb1 Pdpk1 Gng13 Gng12 Gng11 Akt3 Rhoa LOC100912034 Gnb4 Gng4 Gngt2 Gng5 Gngt1 Gng8 Gng10 Akt2 Gng3 ALTERNATIVE COMPLEMENT ACTIVATION%REACTOME DATABASE ID RELEASE 66%10145211 Alternative complement activation Cfd C3 Gzmm C2 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP)%REACTOME DATABASE ID RELEASE 66%10145264 Senescence-Associated Secretory Phenotype (SASP) Rps6ka2 Rps6ka1 Rps6ka3 LOC100912585 Anapc11 Ccna2 Anapc15 Ccna1 Anapc10 Fzr1 Hist1h2bo Hist1h2bcl1 Hist2h3c2 Hist1h2bk Cdk2 H3f3b Cdkn2b Cdkn2c Cdk6 LOC100910200 H2afx Hist1h4b LOC684841 Hist1h2bh LOC100912290 Ube2d1 Hist1h2ail1 Hist1h4m Cdk4 LOC102549173 Ehmt2 LOC103690002 LOC100910152 Ehmt1 LOC100912338 Hist1h3c H2afb3 Hist1h3f Hist2h4 LOC684819 Hist1h3a H2afj Hist2h2aa3 Hist1h2bq Hist2h2aa2 LOC100364835 LOC684762 Anapc7 Cdc26 Cdc27 Cdc23 Ube2c Mapk7 Cdkn1a Cdkn1b Anapc16 Cdc16 Anapc4 Anapc2 Mapk1 Anapc1 Hist1h2bg LOC680097 LOC684797 LOC100912418 Hist1h2ba Hist3h2bb SIGNALING BY INSULIN RECEPTOR%REACTOME%R-RNO-74752.1 Signaling by Insulin receptor Atp6v1d Fgf23 Fgf22 Fgf4 Fgf1 Fgf3 Tlr9 Fgf6 Fgf5 Fgf20 Atp6v1g1 Gab1 Pde3b Atp6v1g2 Atp6v0a4 Atp6v1b2 Fgf16 Atp6v0a2 Fgf17 Atp6v1h Irs2 Atp6v1f Fgf10 Fgf9 Fgfr2 Fgf2 Fgf7 Fgf8 Fgfr3 Trib3 Fgfr1 Fgfr4 Grb10 Insr Ins1 Ins2 Fgf19 Them4 Irs1 Frs2 Atp6v0c Akt2 Pik3r1 Pik3r2 Tcirg1 Atp6v0d1 Atp6v1c2 Atp6v0d2 Atp6v1a Atp6v0e2 Atp6ap1 Atp6v0e1 Atp6v1g3 Atp6v1e1 Atp6v1e2 Atp6v1c1 Atp6v0a1 Pik3c3 Pik3r4 Pdpk1 Mapk1 Pik3cb Ptpn11 Sos1 Shc1 Grb2 SIGNALING BY NODAL%REACTOME%R-RNO-1181150.1 Signaling by NODAL Smad3 Smad2 Foxo3 Foxh1 Drap1 PI3K EVENTS IN ERBB2 SIGNALING%REACTOME DATABASE ID RELEASE 66%10145823 PI3K events in ERBB2 signaling Gab1 Ereg Nrg1 Btc LOC102552659 Pik3r1 Erbb3 Erbb2 Nrg3 Egfr Hbegf Nrg4 Erbb4 Nrg2 Grb2 U12 DEPENDENT SPLICING%REACTOME%R-RNO-72165.1 U12 Dependent Splicing Snrpf Ddx23 RGD1565904 Snrpd1 Eftud2 Polr2g Polr2h Snrpd2 Snrnp25 Snrpd3 Polr2e Zrsr1 Polr2f Polr2j Zcrb1 Zmat5 Sf3b2 Polr2k Snrnp48 Sf3b4 Polr2d Rnpc3 Sf3b3 Polr2i Zrsr2 Polr2b Snrnp35 Sf3b5 Polr2c Polr2a Pdcd7 Gtf2f1 LOC100912534 Gtf2f2 Lsm2 Snrnp200 Prpf6 Sf3b1 Prpf8 Ddx42 Srsf6 Srsf7 Srsf2 LOC100359574 LOC100911822 Ncbp2 Srsf1 Ncbp1 Ybx1 Nhp2l1 Txnl4a Snrpb RHO GTPASES ACTIVATE PKNS%REACTOME%R-RNO-5625740.1 RHO GTPases activate PKNs Rac1 Kdm1a Hist1h2bo Hist1h2bcl1 Hist2h3c2 Pkn1 Hist1h2bk H3f3b Pkn2 Pkn3 Cdc25c Ppp1r12a Ppp1cb Ppp1r14a LOC100910200 H2afx Hist1h4b LOC684841 Hist1h2bh LOC100912290 Hist1h2ail1 Hist1h4m LOC102549173 LOC103690002 LOC100910152 LOC100912338 Hist1h3c H2afb3 Hist1h3f Ywhah Hist2h4 LOC684819 Ywhag Sfn Hist1h3a Ywhaz H2afj Hist2h2aa3 Hist1h2bq Hist2h2aa2 Ywhab Ywhaq Ywhae LOC100364835 LOC684762 Ncoa2 Pdpk1 Rhoa Hist1h2bg LOC680097 LOC684797 LOC100912418 Rhob Hist1h2ba Hist3h2bb Rhoc C6 DEAMINATION OF ADENOSINE%REACTOME%R-RNO-75102.1 C6 deamination of adenosine Adarb1 Adar SERINE BIOSYNTHESIS%REACTOME%R-RNO-977347.1 Serine biosynthesis Psat1 Phgdh Serinc4 Psph Serinc2 Serinc3 Srr Serinc1 NEGATIVE REGULATION OF THE PI3K AKT NETWORK%REACTOME%R-RNO-199418.1 Negative regulation of the PI3K AKT network Ereg Pten Cd80 Nrg1 Cd86 Btc LOC102552659 Erbb3 Erbb2 Nrg3 Egfr Hbegf Esr2 Rac1 Traf6 Nrg4 Fgf23 Fgf22 Fgf4 Fgf1 Il33 Fgf3 Fgf6 Fgf5 Fgf20 Gab1 Pip5k1c Pip5k1b Fgf16 Fyn Pip5k1a Fgf17 Irs2 Fgf10 Fgf9 Fgfr2 Fgf7 Cd19 Fgf2 Fgf8 Fgfr3 Il1rap Trib3 Fgfr1 LOC100909468 Fgfr4 Hgf Esr1 Insr Ins1 Rac2 Ins2 Fgf19 Erbb4 Them4 Irs1 Frs2 Pip4k2b Pip4k2c Akt2 Nrg2 Src Ppp2r5e Pik3r1 Pik3r3 Pdgfra Pik3r2 Pdgfrb Pik3ap1 Il1rl1 Akt1 Cd28 Icos Phlpp1 Ppp2r5c Ppp2cb Pdgfa Ier3 Ppp2r5a Ppp2ca Pdgfb Ppp2r1a Ppp2r5b Pik3cd Vav1 Irak4 Ppp2r1b Mapk1 Pik3cb Akt3 Ptpn11 Rhog Kit Myd88 Kitlg Grb2 METABOLISM OF FOLATE AND PTERINES%REACTOME%R-RNO-196757.1 Metabolism of folate and pterines Mthfs Mthfd1l Mthfd2l Dhfr Mthfr Mthfd2 Mthfd1 Shmt1 Aldh1l2 Aldh1l1 Slc19a1 Slc25a32 Shmt2 Slc46a1 Folr2 ACTIVATION OF C3 AND C5%REACTOME%R-RNO-174577.1 Activation of C3 and C5 C4a C4b C3 LOC100909666 LOC102549354 C2 SHC-MEDIATED CASCADE:FGFR3%REACTOME%R-RNO-5654704.1 SHC-mediated cascade:FGFR3 Kras Fgf16 Fgf17 Fgf9 Fgf2 Fgf8 Fgfr3 Fgf23 Fgf4 Fgf1 Fgf5 Hras Nras Sos1 Shc1 Fgf20 Grb2 BIOLOGICAL OXIDATIONS%REACTOME%R-RNO-211859.1 Biological oxidations Nr1h4 Bpnt1 Smox Abhd14b Cyp1b1 Nat1 Glyatl3 RGD1564480 Acsm1 Nat2 Sult6b1 Podxl2 Glyat Sult4a1 Sult2a1 Nat3 Cyp46a1 Acy3 LOC100910526 Hpgds RGD1562392 Akr7a2 Maoa ste2 Impad1 Tpst1 Tpst2 Sult2b1 NEWGENE_1306455 LOC100910057 Aldh2 Sult1b1 Comt LOC100910881 Sult1a1 Paox Sult1c2 Acy1 Cyp4f39 Cyp39a1 Pomc Ugp2 Cyp2d5 Fdx1 LOC100361547 Slc35d1 Cyp3a23/3a1 Cyp3a73 Cyp2u1 Gsta5 Gss Cyp2c7 Cyp2e1 Gstm4 Cyp2d4 Slc26a2 Cyp3a18 Cyp1a1 Slc26a1 Ptgs1 LOC100910877 Cyp2d2 Cyp1a2 Cyp2d3 Cyp2c6v1 Slc35b2 Slc35b3 Gstm7 Ggct Esd Gclm Gstm5 Gsto2 Gstk1 Cndp2 Gclc LOC100912430 Gstt2 Ggt7 Ggt6 Chac2 Cyp7b1 Chac1 Mgst3 Oplah Cyp7a1 Cyp21a1 Fdxr Cyp2r1 Acss2 Dpep2 Papss2 Papss1 Cyp11b2 Cyp27b1 Gstz1 Ncoa2 Cyp8b1 Akr1a1 Svs1 Dpep3 Dpep1 Doxl2 Doxl1 Cyp19a1 Fdx1l Por LOC100360055 Aoc3 Ces2c Cyp4f17 Mat1a Mat2b Mgst1 LOC100363915 Cyp4f18 Ahcy N6amt1 Ugt2b Nnmt Ugt1a8 Ugt2b37 Mat2a As3mt Ugt1a9 Tpmt Ugt1a6 Tbxas1 Ugt2b35 Mtrr Trmt112 Ugt2a1 Ugt2b15 Gsto1 Hsp90ab1 Ugt1a1 Cyp51 Mtr Ugt2b17 RGD1559459 Ugt1a7c Ugt1a5 Ugt1a3 Ugt1a2 Cyp4f6 LOC100912391 Cyp24a1 Cyp4a2 Cyp4a1 Ptgis Rxra Cyp4a8 Cyp2j10 Ptges3 Ptges3l1 Ncoa1 Cyp2b2 Cyp2c24 Cyp2s1 Cyp2b1 Gstp1 Marc2 Marc1 Aip Cyp2b3 Ephx1 Nqo2 Cyp26c1 Aldh3a1 LOC100910040 Bphl Ahrr LOC100361492 Ahr Maob LOC100910127 Ugdh Ces1d Cyp2c13 LOC100910481 Aadac Cmbl Ces2 Ces2j Cyp2b21 Arnt Ces2e Ces2g Acss1 Cbr3 Ces2h LOC100911763 Aoc1 Cyp2b15 Fmo1 Cyp2b12 Adh4 Fmo2 Cyp2f4 Cyp26a1 Adh6 Cyb5r3 Arnt2 Adh7 Cyb5b Cyp4v3 Aldh1b1 Cyp26b1 LOC100365112 NONCANONICAL ACTIVATION OF NOTCH3%REACTOME%R-RNO-9017802.1 Noncanonical activation of NOTCH3 Aph1b Psenen Ybx1 Aph1a LOC100911293 Notch3 Psen2 Psen1 Ncstn THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION)%REACTOME%R-RNO-2453902.1 The canonical retinoid cycle in rods (twilight vision) Stra6 Rlbp1 Rdh10 Rdh16 LOC100365958 LOC100362350 Rbp4 Ttr Rbp1 Abca4 Rdh11 Lrat Rpe65 Dhrs9 Cyp4v3 Myo7a Sdr9c7 Hsd17b6 REGULATION OF TNFR1 SIGNALING%REACTOME DATABASE ID RELEASE 66%10146056 Regulation of TNFR1 signaling Usp21 Birc3 Birc2 Otud7b Cyld Madd Tax1bp1 Sppl2a Clip3 Ripk1 Otulin Tnf Tradd Xiap Casp8 Tnfaip3 Rnf31 Sharpin Traf1 Usp2 Rbck1 Chuk Traf2 Usp4 Ikbkb RNA POLYMERASE II PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 66%10144902 RNA Polymerase II Promoter Escape Gtf2h1 Gtf2h2 Gtf2e1 Gtf2e2 Mnat1 RGD1565904 Taf11 Polr2g Ercc3 Taf2 Polr2h Taf15 Polr2e Polr2f Polr2j Taf13 Taf9 Polr2k Taf12 Polr2d LOC100911822 Taf7 Polr2i Taf4b Polr2b Polr2c Taf3 Ercc2 Taf6 Polr2a Taf5 Gtf2f1 LOC100912534 Gtf2f2 Gtf2a1 Cdk7 Atp5c1 Taf10 Taf7l Gtf2b Ccnh Gtf2h3 Gtf2h5 Tbp Gtf2h4 Taf9b SUMOYLATION OF DNA METHYLATION PROTEINS%REACTOME%R-RNO-4655427.1 SUMOylation of DNA methylation proteins Dnmt3b Sumo1 Dnmt1 Ube2i RUNX1 REGULATES ESTROGEN RECEPTOR MEDIATED TRANSCRIPTION%REACTOME DATABASE ID RELEASE 66%10146262 RUNX1 regulates estrogen receptor mediated transcription Esr1 Cbfb Runx1 THREONINE CATABOLISM%REACTOME DATABASE ID RELEASE 66%10146296 Threonine catabolism Sdsl Sds Hrsp12 METABOLISM OF RNA%REACTOME DATABASE ID RELEASE 66%10144827 Metabolism of RNA Thoc5 Thoc7 Gtf2h1 Thoc3 Gtf2h2 Thoc2 Thoc1 Ppie Mnat1 Thoc6 RGD1565904 Isy1 Polr2g Polr2h Polr2e Zfp473 Polr2f Polr2j Polr2k Polr2d Polr2i Polr2b Polr2c Ddx39a Polr2a Ddx39b Chtop Xab2 LOC100912534 Prpf19 Ccnh Gtf2h3 Gtf2h5 Gtf2h4 Dcp2 Exosc3 Akt1 LOC100911537 Xrn1 Dcp1a Exosc9 Ercc3 Exosc2 Exosc1 Exosc4 Exosc7 Exosc5 LOC100911822 Aqr Ercc2 Fyttd1 Prkca LOC361990 Phax Sarnp Slu7 Nop58 Lsm10 Lsm11 Psmb7 Psmb1 LOC679894 Ddx21 Poldip3 Psma5 Cdk7 Psma2 Slbp Psmd2 Psmc2 Psmd1 Psmd7 Psmd3 Psmd6 Cwc27 Cwc25 Cwc22 Snrpf Wdr33 Cnot6l Cnot11 Srsf3 Ccar1 Cdc5l Upf3b U2af2 LOC102548514 Cd2bp2 Papola Srsf6 Elavl1 Srsf7 Ppil6 Prpf38a Srsf4 Srsf5 Srsf2 Hnrnph1 Tnks1bp1 Ppih Cnot8 Rqcd1 LOC100359574 Pan2 Ppil1 Cnot3 Ppil3 Ppp2ca Elavl2 Cnot1 Srsf9 Zcchc6 Cnot2 Ppp2r1a Ppil4 Dhx38 Fblim1 Clp1 Cnot7 Hnrnph2 Cnot4 Cwc15 Cherp Magoh Hnrpd Apobec1 Ncbp2 Apobec2 Srsf1 Tbl3 LOC100363335 Tsr1 Ctnnbl1 Emg1 Ppwd1 Wdr75 LOC500684 Wtap Ncbp1 LOC680519 Apobec4 Dhx9 Wdr18 Ybx1 Wdr43 LOC100910750 Wdr46 Nhp2l1 C1d Cstf2t Nob1 Eif4a3 Fcf1 Sympk Wdr12 Mapkapk2 Bud31 Senp3 Hnrnpul1 Txnl4a LOC100910660 Hnrnpk Srrm1 Wdr36 Hnrnpu Ebna1bp2 Hnrnpr Wbp4 Smn1 Usp39 Hnrnpl Snrpa Hnrnpm Hnrnpf Cdc40 Snrpc Hnrnpa2b1 Snrpb Rpp25 RGD1565693 Riok3 Riok1 Utp14a Bysl NEWGENE_1564769 Rpp21 Pdcd11 Rpp40 Skiv2l2 Heatr1 Riok2 Rpp38 Rrp36 Rpp30 Bop1 Nxf7 Utp20 Dhx37 Gle1 Mettl14 Nxf2 Nxf1 Utp18 Gnl3 Utp15 Utp11l Pno1 Pwp2 Wbscr22 Mphosph6 Imp4 Imp3 Nop56 Tex10 Utp6 Rcl1 Nol6 Utp3 Ddx20 Ncl Gemin7l1 Nop14 Xrn2 Rrp9 Snw1 Rrp7a Mettl3 Pes1 Gemin5 Gemin7 Gemin6 Gemin8 Tcp11x2 Exosc10 Krr1 Nol9 Nxt1 Mphosph10 Gemin2 LOC100910568 Rpp14 Cirh1a Diexf RGD1563307 Ddx52 Ltv1 Wdr3 A1cf Snupn Noc4l Ddx49 Ddx47 Las1l Fbl Csnk1d Csnk1e Hspb1 Nup88 Supt5h Dcaf13 Nup85 Rnmt Rngtt Rae1 Rnps1 Nup93 Dhx16 Dhx15 Sugp1 Nup98 Prpf40a Sart1 Snrpb2 Nup107 Magohb Phf5a Rbm8a Ddx23 Pcf11 Fip1l1 Hnrnpa0 U2surp Nudt21 Nup210 Snrpd1 Eftud2 LOC100364748 Snrpd2 Snrpd3 Rbm5 Tra2b Sf3b2 Sf3b4 Nupl2 Sf3b3 Pqbp1 Sf3b5 Nupl1 Cstf2 Rbm22 Lsm8 Puf60 Wbp11 Lsm7 U2af1l4 Lsm6 Lsm4 Lsm3 Lsm5 Cpsf7 Cpsf2 Cpsf3 Cpsf4 Lsm2 Rbm17 Cstf1 Snrnp200 Cpsf1 Tgs1 Smptb Gpkow Plrg1 Xpo1 LOC679753 Prpf6 Sf3a3 Sf3b1 Prpf8 Prpf4 Nup205 Ddx46 Sf3a1 Prpf31 Ddx42 Bcas2 Prpf3 Sf3a2 Crnkl1 LOC100360750 Syf2 Fus Smndc1 Prcc Rbmx Adarb1 G6pc LOC100359916 Adar Nup155 Snrpa1 Snrnp70 Hbs1l Dcps Lsm1 Nt5c3b Patl1 Ttc37 Edc3 Edc4 Dcp1b Nup153 Tpr Nup54 Pom121 Nup62 LOC100912571 Psmc6 Nup43 Psmb10 Nup133 Psmb8 Rps20 Psmb9 Rps27l Psmb4 Aaas Psmb11 Psmb5 Psmf1 Psmb6 Psmd4 Psmb2 Psmd5 Npap60 Psmd8 Psmd9 Psmb3 Nup35 Psma8 Snrnp25 Zrsr1 Nup37 Zcrb1 Psmd11 Zmat5 Psmd12 Snrnp48 LOC100360573 Rnpc3 Zrsr2 Psmd13 Snrnp35 Eif4g1 Psmd14 Pdcd7 Rps4x LOC100359951 Rpl30 LOC100359593 Wdr61 Rpl4 LOC100359503 Rplp0 LOC100362640 Rpl6 Rpl13a Rpl26 Rps3 LOC100363800 Rps15a LOC685963 Rpl32 Rps2 Rps13 Gspt1 Pnrc2 Rps12 Pabpc2 Pabpc6 LOC100911372 Rplp1 Rpl39 LOC100361854 LOC684988 Rpl38 Gspt2 LOC103689992 Rpl22 Rps5 Psmc3 Rpl23 Rps7 Rpl10l Rps6 Smg8 Upf1 Rpl15 RGD1563300 Rpl19 Rpl10a Eif4a2 Smg9 LOC100362830 Ranbp2 LOC690468 Rpl29 Eif4a1 Smg7 LOC100363012 LOC680559 Smg6 Smg5 Rpl39l LOC100362149 Rpl41 LOC100912182 LOC100360057 Upf3a Rpl36al Etf1 Rpl13 Rpl3l Rpl36a Ywhaz Ywhab Khsrp Anp32a Tnfsf13 Gtf2f1 Gtf2f2 Ddx5 Prkcd Rps16 LOC100911431 Pabpc1 Rps18 LOC100360679 Rps15 Eif4b Rps3a Psmc5 Psma1 Psma4 Psmc1 Psma3 Psmc4 Psma6 Ppp2r2a Psme1 Psme2 SYNTHESIS OF DOLICHYL-PHOSPHATE MANNOSE%REACTOME DATABASE ID RELEASE 66%10145103 Synthesis of dolichyl-phosphate mannose Dpm3 Dpm2 Dpm1 LOC100910177 RNA POLYMERASE III TRANSCRIPTION INITIATION%REACTOME%R-RNO-76046.1 RNA Polymerase III Transcription Initiation Bdp1 Polr3d Snapc3 Snapc4 Polr3c Polr3a Polr3e Polr3b RGD1565904 Polr3h Polr2h Polr3k Polr2e Polr2f Polr1c Polr3g Polr2k Polr3f Gtf3c6 Gtf3c5 LOC100912534 Gtf3c1 Gtf3c3 Gtf3c4 Polr3gl Brf1 Brf2 Pou2f1 Gtf3a Snapc5 Snapc2 Tbp ADENOSINE P1 RECEPTORS%REACTOME%R-RNO-417973.1 Adenosine P1 receptors Adora3 Adora2a Adora2b LOC100911796 LOC100363178 Adora1 LOC100365814 WAX BIOSYNTHESIS%REACTOME%R-RNO-8848584.1 Wax biosynthesis Awat1 Awat2 Far2 Far1 ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 66%10145451 Acetylcholine Neurotransmitter Release Cycle Chat Rab3a Rims1 Stx1a Cplx1 Syt1 Vamp2 Stxbp1 Ppfia1 Ppfia2 Ppfia3 Ppfia4 Bzrap1 Slc5a7 TRAIL SIGNALING%REACTOME%R-RNO-75158.1 TRAIL signaling Cflar Fadd Tnfsf10 Casp8 DIGESTION%REACTOME DATABASE ID RELEASE 66%10145278 Digestion Pir Amy2a3 Pnliprp1 Chia RGD1309110 Pnliprp2 Alpp Alpi Pnlip Amy1a Chit1 Guca2b Guca2a Lct Si Chi3l3 Gucy2c Alppl2 Lipf Clps CELLULAR SENESCENCE%REACTOME%R-RNO-2559583.1 Cellular Senescence Mdm2 Rad50 Ccna2 Ccne2 Ccna1 Ccne1 Atm Cdk2 Mapkapk5 Nbn Mre11a Ube2d1 Cdk4 Jun Phc1 Phc2 Anapc7 Cdc26 Mapk9 Cdc27 Mapk8 Cdc23 Fos Mapk7 Ube2c Cdkn1a Cdkn1b Txn1 Anapc16 Cdc16 Mapkapk3 Id1 Anapc4 Map4k4 Anapc2 Mapkapk2 Anapc1 Mapk1 Mapk14 Mapk11 Mapk10 Map2k7 Asf1a Map2k6 Ets1 Map2k4 Ep400 Ets2 Tnik LOC100911837 Mink1 Map3k5 Rps6ka2 Rps6ka1 Rps6ka3 Erf Ubn1 LOC100912585 Anapc11 Cabin1 Anapc15 Anapc10 Fzr1 Hira Tinf2 Hist1h2bo Scmh1 Hist1h2bcl1 Hist2h3c2 Cbx4 Cbx2 Hist1h2bk Cbx8 H3f3b Cbx6 Bmi1 Rnf2 Kdm6b Ring1 Phc3 Cdkn2b Terf2ip Cdkn2c Cdk6 Eed LOC100910200 H2afx Hist1h4b LOC684841 Hist1h2bh Acd LOC100912290 Rbbp7 Pot1b Hist1h2ail1 Hist1h4m LOC102549173 LOC103690002 Ehmt2 LOC100910152 Ehmt1 Pot1 LOC100912338 Hist1h3c H2afb3 Hist1h3f Hist2h4 LOC684819 Hist1h3a H2afj Hist2h2aa3 Hist1h2bq Hist2h2aa2 LOC100364835 LOC684762 Terf1 Terf2 LOC100910954 Mdm4 Hist1h2bg Ezh2 LOC680097 LOC684797 LOC100912418 Hist1h2ba Hist3h2bb G ALPHA (S) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 66%10145517 G alpha (s) signalling events Olr1442 Olr1443 Olr1548 Olr80 Olr1440 Olr1547 Pde4a Pde4d Pde4c Olr1436 Ptgir Olr1569 Olr1567 Olr1421 Olr1568 Olr1565 Olr1566 Olr1538 LOC100912374 Olr1539 Olr1437 Olr1439 Olr1433 Olr1434 Olr1435 LOC103690304 Olr83 LOC100912370 Olr1533 Olr1432 Olr1535 Olr1537 Olr1536 Olr81 Olr1449 Olr1542 Olr1541 Olr1540 Olr1445 LOC103693022 LOC100912463 Mc3r Pde1b Mc4r Rln3 Mc2r Gng10 Nps Pde3a Pde2a Cyct Pde10a Pde11a Gphb5 Gpha2 Fshr Tshr Lhcgr LOC100909513 LOC100360745 Olr1600 Olr1605 Olr1405 Olr1601 Olr1407 Olr1404 Olr1406 LOC100910837 Olr1368 Olr1369 Olr226 LOC100911348 Olr229 Olr227 Olr1602 LOC684170 LOC103692138 Lhb Olr1504 Olr233 Olr428 Olr232 Olr427 Olr1505 Olr234 LOC100911377 Olr1400 LOC100911376 Olr231 Ptgdr Olr425 Olr1501 Olr230 Olr208 Olr1202 Olr244 LOC103693685 Olr1519 Olr203 Olr411 Olr209 Olr1007 Olr1006 LOC100911223 Olr237 Olr434 Olr1306 Olr442 Olr441 Olr113 Olr210 Olr1520 Olr114 Olr1523 Olr218 Olr1522 Olr1521 Olr206 Olr1118 Olr204 Olr205 LOC100911398 Tshb Ptger2 Cga Olr1115 Olr1117 Pde7a Olr1734 Olr1340 Olr485 Olr486 Olr16 Mc5r Olr1735 LOC100911043 Olr1737 Gnal Rxfp1 Olr14 Rxfp2 Olr1736 Olr488 Insl3 Olr484 Pde7b Olr1730 LOC100912515 Olr1627 Olr491 Olr1626 Olr490 Olr1621 LOC100912408 Olr1625 Olr1624 Olr200 Olr339 Olr1345 Olr338 Olr1343 Olr202 Olr1344 Olr1341 Olr1356 Taar9 LOC100912605 LOC100911849 Hrh2 Fshb LOC100910199 Taar6 Olr346 Taar5 Taar2 Olr1214 Olr450 Olr499 Olr496 LOC100912505 Olr493 Olr1606 Olr1607 Olr1749 Olr1608 Olr1362 Olr459 Olr458 Olr1361 Adora2a Olr1366 Adora2b Olr1364 Olr360 Olr462 Olr1611 Olr1610 Olr1358 Olr1612 Olr20 Olr24 Olr23 Olr1456 LOC100912431 Olr1597 Olr1593 Olr1592 Olr1450 Olr1452 Olr1598 Olr1454 LOC100909966 LOC100365887 LOC100912159 Olr1654 LOC103693822 Olr30 Olr32 Olr34 Olr331 Olr332 Olr1643 Olr334 Olr330 Olr1642 Olr1644 Olr1645 Olr473 Olr470 Olr1744 Olr1641 Olr1743 Olr1746 Olr472 Olr1640 Pde8b Olr477 Olr475 Pde8a LOC100911479 Olr1235 Olr1738 LOC103690286 Olr1231 Olr329 Or7e24 LOC103690280 Olr326 Olr325 Olr1339 Olr1639 Olr13 Olr12 Olr1637 Olr1638 Olr340 Olr341 LOC102555599 Olr1635 Olr1630 Olr1631 Olr1632 Olr1633 Olr1423 Olr1560 Olr63 LOC100912684 Olr1424 Olr1564 Olr1425 Olr1422 Olr1558 Olr1559 LOC684179 Olr1555 Ptgdrl Olr67 Olr68 Olr69 Olr1416 Olr70 Olr1418 Olr1417 Olr1551 Olr1557 Olr1553 LOC686967 Olr77 LOC100909611 Olr1693 Rtp4 Olr74 RGD1562400 Olr78 Olr75 Olr1583 Olr1589 Olr1488 LOC100912420 Olr1582 LOC100909993 Rtp3 Rtp2 Olr1475 Olr1470 LOC687110 Olr1576 Olr49 Olr46 Olr1588 Olr48 Olr1467 Arrb1 Olr1468 Olr1469 Olr50 Arrb2 Olr51 Olr59 Olr1671 Olr1471 Olr1667 Olr29 LOC100909831 Adrbk1 Olr27 Olr25 Olr1462 LOC100912540 LOC100911586 Gpr39 Olr663 Olr660 Olr561 Olr1024 Olr560 LOC100910009 Olr158 Olr557 LOC100910335 Olr164 Olr659 Olr160 Olr657 Olr662 Olr664 Olr1868 Olr1199 Gpr27 Olr653 LOC100910402 Olr651 Olr650 Olr294 LOC100911909 Olr544 Olr1197 Olr1196 Olr1195 Olr1194 Olr1198 LOC100910409 Olr1128 LOC100911893 LOC100910928 Olr323 Olr119 Olr1126 LOC100912097 Olr1125 Olr420 Olr217 Olr1121 Olr1122 Olr1129 Olr322 Gpr84 Olr214 Olr215 Olr414 Olr1512 Olr1513 Olr416 Olr556 Gpr150 Olr1511 Olr413 Olr1517 Olr319 Olr120 Olr321 Olr1514 LOC100911380 Olr417 Olr418 LOC100910041 Olr259 Olr1163 Olr1166 LOC684208 Olr127 Pomc Olr530 Olr126 Olr931 Olr674 Olr129 Olr532 Olr1174 Olr670 Gpr45 Olr675 Olr892 Olr247 Olr1156 Olr190 Olr194 Olr267 LOC500460 Olr192 Olr262 Olr1064 Olr896 Olr263 LOC100910049 Olr698 Olr799 LOC103693566 Olr922 Olr684 Olr1186 LOC100910120 Olr536 Olr1185 Olr143 Olr535 Olr140 Olr142 Olr148 LOC100910648 Olr1016 Olr149 Olr951 Gpr25 LOC100910224 Olr666 Olr1179 Olr522 Olr130 Olr527 Olr526 LOC100910637 Olr132 LOC100910010 Olr529 Olr528 Olr139 Olr137 Olr686 Olr1877 LOC100910559 Olr186 Olr189 Olr1081 Olr1147 Olr188 Olr584 Olr1082 Olr281 Olr382 Olr384 Olr1086 Olr1087 Olr587 Olr581 Olr282 Olr776 Olr582 Olr777 Olr583 Olr283 Olr962 Gpr15 Olr964 Olr285 Olr286 Olr1135 Olr1132 Olr172 LOC100910051 Olr1130 Olr170 Ghrh Olr198 Ramp3 Olr588 Vipr2 Olr199 Sct Olr1155 Gip Olr597 Gipr Olr1057 Pth1r Olr196 Iapp LOC100911805 Crhr2 Grk6 Gcgr Olr252 Olr1052 Crhr1 Olr598 Glp2r Olr695 Pth2 Olr251 Ramp2 Olr250 Ghrhr Olr697 LOC100910999 Olr590 Grk5 LOC100910445 Olr1143 Olr180 Olr690 Olr1144 Olr783 Olr379 Olr1142 LOC100910162 Olr782 Gpr176 LOC100911839 Olr184 Olr845 LOC100910274 Olr847 Olr848 Olr1391 Olr852 Olr1496 LOC686792 LOC100912204 Olr1096 LOC100365798 RGD1562066 Olr844 Olr841 Olr744 Olr745 LOC100909686 Olr878 LOC100910597 Olr1376 Olr850 Olr851 LOC100909578 LOC100909683 LOC100910294 LOC687097 LOC100909884 LOC100909885 Olr1374 Olr1372 Olr1373 Olr1370 Olr1071 Olr569 Olr174 Olr175 Olr774 Olr176 Htr4 Olr1274 Olr1076 LOC100910876 Olr575 Olr1075 Olr373 Olr1275 Olr1070 Olr1137 Htr7 Olr375 Olr377 Olr378 Olr372 Olr1079 Olr374 Olr1073 Olr854 Olr853 Olr279 LOC100911035 Olr765 Olr278 Olr376 Htr6 LOC100910256 Olr834 Olr641 LOC100909438 LOC100909796 Gpr83 LOC690821 LOC100912217 Olr601 Olr602 Olr604 Olr709 Olr609 Olr607 Olr608 LOC687088 Olfr873 Olr806 LOC686677 Olr702 Olr808 Olr705 Olr704 Olr807 Olr519 Olr614 Olr718 Olr811 Olr514 Olr515 Olr611 Olr610 Olr819 Olr716 Olr713 Olr816 Olr717 Olr714 Olr813 Olr812 Olr1382 Olr1381 Olr1384 Adrb3 Olr1383 Olr711 LOC100912327 Olr818 Olr712 Olr724 Olr1380 Reep6 LOC684683 Olr720 Olr722 LOC686660 Olr1385 Olr1378 Reep1 Reep5 Olr729 Reep4 Reep3 Reep2 Olr725 Pth Sctr Adm Calcb Vip Calca Ramp1 Adcyap1r1 Adcyap1 Pth2r Adm2 Crh Gnb3 Gnb5 Gnb2 Gnb1 Gng13 Gng12 Gng11 LOC100912034 Gnb4 LOC687065 Glp1r Drd5 Gcg Gng4 Drd1 Gngt2 Gng5 LOC684539 Olr820 Gngt1 Gng8 Olr821 Gng3 Olr823 Avp Pde3b Adrb2 TNFR1-MEDIATED CERAMIDE PRODUCTION%REACTOME DATABASE ID RELEASE 66%10146089 TNFR1-mediated ceramide production Nsmaf Smpd2 Smpd3 Tnf SIGNALING BY RETINOIC ACID%REACTOME DATABASE ID RELEASE 66%10145381 Signaling by Retinoic Acid Dhrs3 Cyp26c1 Crabp1 Rarg Rxra Pdhb Sdr16c5 Pdk3 Pdk4 Pdk1 Pdk2 LOC100365902 Dhrs4 Rdh14 Pdha2 Rdh13 Aldh8a1 Pdha1 Pdhx Ppard Fabp5 Pdha1l1 Dhrs9 Rdh10 Cpt1b Rdh16 Akr1c2 LOC100365958 Rxrg Cpt1a Akr1c12l1 Akr1c3 Dlat Rara Akr1c19 Rarb Rdh11 Cyp26a1 Adh6 Akr1c13 Akr1c14 RGD1564865 Akr1c12 Cyp26b1 Akr1c1 Dld DIMERIZATION OF PROCASPASE-8%REACTOME%R-RNO-69416.1 Dimerization of procaspase-8 Faslg Traf2 Cflar Fadd Ripk1 Tradd Tnfsf10 Casp8 Fas REGULATION OF GAP JUNCTION ACTIVITY%REACTOME DATABASE ID RELEASE 66%10145308 Regulation of gap junction activity Gja1 Src PROLONGED ERK ACTIVATION EVENTS%REACTOME DATABASE ID RELEASE 66%10145181 Prolonged ERK activation events Ntrk1 Ngf Kidins220 Crk Rap1a Crkl Frs2 Rapgef1 LOC100911248 RELEASE OF APOPTOTIC FACTORS FROM THE MITOCHONDRIA%REACTOME DATABASE ID RELEASE 66%10145018 Release of apoptotic factors from the mitochondria Diablo Bax Bak1 LOC100360940 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE%REACTOME%R-RNO-1660499.1 Synthesis of PIPs at the plasma membrane Pik3r5 Bmx Pten Mtmr9 Mtmr6 Pik3r3 Pik3r1 Pik3r6 Pik3r2 Ptpn13 Synj1 Inpp4a Plekha4 Plekha3 Inpp4b Inpp5d Plekha5 Mtmr14 Plekha8 Synj2 Plekha1 Pik3cd Mtmr3 Pik3cg Inpp5j Mtmr1 Pip5k1c Rufy1 Pi4k2a Pip5k1b Pip5k1a Pik3cb Pik3c2a Ocrl Pip4k2b Pik3c2b Pip4k2c Pi4k2b Pik3c2g TRANSPORT AND SYNTHESIS OF PAPS%REACTOME%R-RNO-174362.1 Transport and synthesis of PAPS Slc35b2 Slc26a2 Slc35b3 Slc26a1 Papss2 Papss1 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING%REACTOME DATABASE ID RELEASE 66%10145207 Downregulation of TGF-beta receptor signaling Smad3 Smad2 Strap Pmepa1 Tgfbr1 Tgfb1 Bambi Tgfbr2 Mtmr4 Stub1 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI)%REACTOME%R-RNO-162710.1 Synthesis of glycosylphosphatidylinositol (GPI) LOC100910143 LOC100910849 Pigm Pigw Pigl Pigv Pigg Pigy Pigx Pigh Pign Pigq Pigc Pigp Pigb Piga Dpm2 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS%REACTOME%R-RNO-997272.1 Inhibition of voltage gated Ca2+ channels via Gbeta gamma subunits Kcnj4 Kcnj6 Kcnj16 Gnb3 Gnb2 Gnb1 Gng12 Kcnj2 Kcnj3 Kcnj15 Kcnj9 Kcnj5 Gng4 Gngt2 Gabbr1 Gng5 Kcnj12 Gngt1 Gng10 Gng8 Gabbr2 Gng3 PROTON-COUPLED NEUTRAL AMINO ACID TRANSPORTERS%REACTOME DATABASE ID RELEASE 66%10145510 Proton-coupled neutral amino acid transporters Slc36a2 Slc36a1 ERYTHROPOIETIN ACTIVATES PHOSPHOINOSITIDE-3-KINASE (PI3K)%REACTOME DATABASE ID RELEASE 66%10146294 Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Pik3r5 Gab1 Pik3cb Pik3r1 Irs2 Lyn Epor Pik3cd Pik3cg Epo METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS%REACTOME DATABASE ID RELEASE 66%10145925 Metabolism of Angiotensinogen to Angiotensins Cpb2 Cpb1 Ren Agt Ace LOC691670 Ctsz Atp6ap2 Ctsd Gzmf Ace3 Cpa3 Ctsg Npepo Gzmn LOC100910060 Cma1 Mme ION CHANNEL TRANSPORT%REACTOME DATABASE ID RELEASE 66%10145600 Ion channel transport Atp6v1d Trpc4ap Raf1 Sri Atp6v1g1 Atp6v1g2 Atp6v0a4 Atp6v1b2 Atp6v0a2 Atp6v1h Atp6v1f Atp8a1 Trpm2 Atp6v0c Pdzd11 Atp6v0d1 Atp6v1c2 Atp6v0d2 Vps25 Atp6v1a Atp6v0e2 Atp6v0e1 Atp6v1g3 Atp6v1e1 Atp6v1e2 Atp6v1c1 Ano6 Scnn1b Camk2g Best1 Best3 Best2 Atp2b4 Scnn1g Tpcn2 Scnn1a Clcn4 Unc79 Atp2b2 Atp2b1 Slc9b1 Camk2d Clcn7 Clcn6 Clcn5 Camk2a Ano10 Wwp1 Ano3 Clic2 Asic4 Asic5 Ano1 Trdn Atp7a Atp2a2 Atp7b Best4 Pln Clcnkb Asic3 Atp2a3 Slc9b2 Slc17a3 Fxyd2 Sgk2 Fxyd3 Fxyd4 Sgk3 Atp10b Clcn1 LOC100912455 Wnk4 Atp11c Tcirg1 Sln Ostm1 Wnk1 Wnk2 Wnk3 Atp9b Clcn2 Fxyd6 Atp6ap1 Atp10d Fxyd7 Stom Atp1b3 Atp1b2 Atp6v0a1 Clca4 Atp1b1 Trpv4 Fkbp1b Trpv5 Atp8b3 Trpv6 Atp8b2 Atp8b1 Ano9 Ryr2 Ano4 Ano7 Atp2c2 Clca2 Atp2c1 Sgk1 Atp11a Stoml3 Mcoln2 Atp12a Mcoln3 Atp13a5 Trpv1 Atp13a4 Trpc5 Atp13a2 Trpm6 Ttyh1 Trpm3 Ttyh2 Trpm8 LOC100361584 Trpm5 Atp8a2 Trpc3 Atp1a4 Trpc7 Atp4b Trpm1 Atp4a Trpc4 Bsnd Mcoln1 Atp1a1 Trpc6 Atp1a2 Trpv3 Atp13a1 Atp1a3 Trpa1 CREB3 FACTORS ACTIVATE GENES%REACTOME DATABASE ID RELEASE 66%10146248 CREB3 factors activate genes Creb3l3 Crebrf Creb3 Mbtps1 Mbtps2 ORC1 REMOVAL FROM CHROMATIN%REACTOME%R-RNO-68949.1 Orc1 removal from chromatin Psmc6 Psmb10 Psmb8 Psmb9 Psmb4 Psmb11 Psmb5 Psmf1 Psmb6 Psmd4 Psmb2 Rbx1 Cul1 Psmd5 Psmd8 Psmd9 Psmb3 Psma8 Psmd11 Psmd12 Ccna2 Ccna1 Psmd13 Psmd14 Mcm2 Mcm4 Mcm3 Cdk2 Mcm5 Mcm6 Psmc3 Mcm8 Mcm7 Orc4 Orc5 Orc6 Orc1 Orc2 Orc3 Cdc6 G6pc Psmb7 Psmb1 Skp1 Psma5 Skp2 Cdt1 Psma2 Psmc5 Psmd2 Psma1 Psma4 Psmc1 Psma3 Psmc4 Psmc2 Psma6 Psme1 Psmd1 Psme2 Psmd7 Psmd3 Psmd6 SIGNALING BY FGFR2%REACTOME DATABASE ID RELEASE 66%10145256 Signaling by FGFR2 Frs3 RGD1565904 Fgf23 Fgf22 Polr2g Fgf4 Polr2h Fgf1 Polr2e Fgf3 Polr2f Polr2j Fgf6 Polr2k Fgf5 Polr2d Polr2i Polr2b Polr2c Polr2a Fgf20 Gab1 Mknk1 Gtf2f1 Esrp2 LOC100912534 Gtf2f2 Esrp1 Fgf16 Rbfox2 Fgf17 Tia1 Fgf10 Tial1 Fgfbp3 Fgf9 Fgfbp1 Fgfr2 Fgf2 Fgf7 Spry2 Cbl Fgf8 Fgfr3 Fgfr1 Fgfr4 Fgf19 Frs2 Kras Src Pik3r1 Hnrnph1 Ppp2cb Ppp2ca Ppp2r1a LOC100911822 Ncbp2 Ncbp1 Mapk1 Ptpn11 Plcg1 Hras Nras Hnrnpm Hnrnpf Sos1 Shc1 Grb2 AMINE OXIDASE REACTIONS%REACTOME DATABASE ID RELEASE 66%10145056 Amine Oxidase reactions Maob Smox Maoa RGD1564480 Paox TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION%REACTOME%R-RNO-948021.1 Transport to the Golgi and subsequent modification Mgat2 Mgat5 Areg Stx5 Sec24a Bet1 Sec24b Arf5 Dync1li2 Copa Cnih1 Sec24d Mgat3 Mgat1 Arf4 Dync1i2 Lhb Ctage5 Man1c1 Gbf1 Man1a1 Cnih3 Cnih2 Tgfa Cog4 Cog6 Cog8 Cog3 Man2a1 Fut8 Cog1 Man2a2 Cog2 Sec23ip Mgat4b Lman1l Mgat4a Cog7 LOC102555167 Dynll2 Copz2 Dync1i1 Copz1 Col7a1 Lman2 Ykt6 F8 Sec16a Sec24c Scfd1 Sec16b Lman1 Cga Trappc2 Tmed7 Tmed3 Trappc5 Tmed2 Napg Napb Copb1 Napa Chst8 Tmed9 Tfg Nsf Trappc3 LOC100910318 Kdelr1 Tbc1d20 Capza2 Capza3 Arcn1 Kdelr2 St3gal4 Ppp6r3 Trappc1 Ppp6r1 Kdelr3 Trappc10 LOC100910557 Sptan1 Ppp6c Manea Actr10 Trappc2l Cd59 Dync1h1 Dync1li1 Trappc6a Trappc6b B4galt1 Copg1 Ankrd28 B4galt3 Sec13 Dctn5 B4galt2 Sar1b Dctn6 B4galt6 B4galt4 B4galt5 Ins1 Ins2 Rab1b Rab1a Dctn4 Tmem115 Folr1 Arfgap2 Dctn1 Ank1 Ctsc Dctn2 Uso1 Golgb1 Arfgap3 Gorasp1 Ctsz Arfgap1 Dctn3 Spta1 Mcfd2 Preb Chst10 St8sia3 Capzb Sec22b Cope Sec23a Sptbn1 Sec31a Sec22a Stx17 Csnk1d St6gal1 Man1a2 Gosr2 Actr1a LOC100363782 Gosr1 Tmed10 L1CAM INTERACTIONS%REACTOME DATABASE ID RELEASE 66%10144965 L1CAM interactions Ank1 Src Gap43 Rdx Egfr Nrp1 Kif4a Ranbp9 Sptan1 Rac1 Cltc L1cam Csnk2a2 Ezr Clta Nfasc Dnm2 Spta1 Csnk2a1 Ap2s1 Vav2 Ap2a1 Ap2m1 Ap2a2 Csnk2b Dnm1 Dnm3 Sdcbp Ncam1 Sptbn1 Lypla2 Msn Fgfr1 Mapk1 Dpysl2 Sh3gl2 Nrcam Pak1 Itga2b Map2k2 PROLACTIN RECEPTOR SIGNALING%REACTOME DATABASE ID RELEASE 66%10145783 Prolactin receptor signaling Prl Skp1 Sh2b1 Gh1 Ghr Btrc Rbx1 Cul1 ACETYLATION%REACTOME DATABASE ID RELEASE 66%10145083 Acetylation Nat1 Nat2 Nat3 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII%REACTOME DATABASE ID RELEASE 66%10145658 CREB phosphorylation through the activation of CaMKII Grin2d Camk2g Grin2b Grin1 Nefl Dlg1 Dlg2 Dlg3 Camk2d Actn2 Camk2a Lrrc7 Creb1 Dlg4 FORMATION OF XYLULOSE-5-PHOSPHATE%REACTOME DATABASE ID RELEASE 66%10146116 Formation of xylulose-5-phosphate Xylb Akr1a1 Sord Cryl1 Dcxr BETA DEFENSINS%REACTOME DATABASE ID RELEASE 66%10145858 Beta defensins Defb26 Defb28 Ccr6 Defb30 Defb18 Defb36 Defb14 Defb12 Defb29 Defb49 Defb25 Tlr10 Defb43 Defb44 Defb13 Defb41 Defb1 Defb22 Defb23 Defb20 Defb21 Tlr2 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY%REACTOME%R-RNO-399721.1 Glutamate binding, activation of AMPA receptors and synaptic plasticity Ap2a2 Camk2g Mdm2 Dlg1 Gria3 Gria4 Grip1 Grip2 Camk2d Pick1 Camk2a Cacng8 Akap5 Prkca Prkcb Nsf Ap2s1 Cacng2 Cacng3 Cacng4 Ap2a1 Myo6 Dlg4 Ap2m1 STRIATED MUSCLE CONTRACTION%REACTOME%R-RNO-390522.1 Striated Muscle Contraction Tnni1 Tnnt3 Tnni2 Tnnt2 Tnni3 Actn2 Tnnt1 Tmod2 Tnnc2 Actn3 Mybpc3 Des Tmod4 Tmod3 Vim Tmod1 Tpm4 Tpm2 Myl3 Myl4 Mybpc2 Tpm3 Tnnc1 Myh6 Dmd Myl1 ABC TRANSPORTERS IN LIPID HOMEOSTASIS%REACTOME DATABASE ID RELEASE 66%10145461 ABC transporters in lipid homeostasis Abcd2 Abcd3 Abcd1 Pex3 Abca3 Abca2 Apoa1 Abca6 Abca5 Abcg4 Abcg1 Abca7 Abcg8 Abcg5 RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF MYELOID CELLS%REACTOME DATABASE ID RELEASE 66%10146266 RUNX1 regulates transcription of genes involved in differentiation of myeloid cells Cbfb Crebbp Runx1 ESR-MEDIATED SIGNALING%REACTOME DATABASE ID RELEASE 66%10145830 ESR-mediated signaling Ppp5c Yy1 Esr2 RGD1565904 Polr2g Polr2h Polr2e Polr2f Polr2j Polr2k Polr2d Polr2i Kdm1a Polr2b Polr2c Polr2a LOC100912534 Sp1 Hsp90ab1 Cdk9 Hdac1 Jun LOC100911822 Fos Mapk1 Fkbp5 Med1 Atf2 Ppid Ppidl1 Cited1 Hist1h2bo Hist1h2bcl1 Nr5a2 Gtf2f1 Hist2h3c2 Gtf2f2 Hist1h2bk Kdm4b H3f3b Carm1 Greb1 Usf1 Gtf2a1 Foxa1 LOC103692716 Bmyc Ptges3 Hdac1l Prmt1 Zfp217 Ptges3l1 Esr1 Pou2f1 Cbfb Tle3 Gata3 Fkbp4 Ddx5 Erbb4 Crebbp Nrip1 Pgr Ncoa1 Tbp Runx1 LOC100910200 H2afx Hist1h4b LOC684841 Hist1h2bh LOC100912290 Hist1h2ail1 Hist1h4m LOC102549173 LOC103690002 LOC100910152 LOC100912338 Hist1h3c H2afb3 Hist1h3f Hist2h4 LOC684819 Hist1h3a H2afj Hist2h2aa3 Hist1h2bq Hist2h2aa2 LOC100364835 LOC684762 Ncoa2 Hist1h2bg LOC680097 LOC684797 LOC100912418 Hist1h2ba Hist3h2bb G ALPHA (Q) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 66%10145036 G alpha (q) signalling events Gpr39 Npff Plcb1 Npffr2 RGD1560028 Hcrt Npffr1 Qrfp LOC100909783 Egfr Plcb3 Ffar1 Hbegf Gnaq Gna11 Gna14 Ghrl Gna15 Plcb4 Kng1l1 F2rl3 Hcrtr1 Qrfpr F2r F2 Hcrtr2 F2rl2 Uts2 Ntsr2 Trhr Nmu Ntsr1 Pik3r3 Anxa1 Pmch Htr2c Htr2a Dgkk Dgki Tac3 Kiss1 Htr2b Tac1 Lpar5 Edn2 Ednra Ptafr Ednrb Grp Edn3 Grpr Ffar4 Lpar1 Lpar3 Edn1 Lpar2 F2rl1 Oxtr Oxt Nmb LOC100909648 Avpr1b Xcl1 Avpr1a Ccl9 Ccl6 Dgkg Gpr4 Dgkd Dgke Agt Dgka Mapk7 Dgkb Gpr132 Gnb3 Gpr143 Gnb5 Rgs3 Opn4 Gnb2 Rgs19 Gnb1 Rgs2 Gng13 Rgs18 Gng12 Hrh1 Gng11 Mapk1 Chrm1 Chrm5 Ghsr Itpr1 Arhgef25 Dgkz Creb1 LOC100909523 Itpr3 Dgkq Nts Prkca LOC100912034 Dgkh Gnb4 Cysltr2 Gcg Cysltr1 Gng4 Gpr65 Gngt2 Gpr68 Gng5 Ptgfr Gngt1 Prkch Gng8 Ptger1 Gng3 Chrm3 Agtr1b Agtr1a Prokr2 Casr Grm1 Cckar Uts2r Prokr1 NMS Gprc6a Rps6ka2 Xcr1 Rps6ka1 App Rps6ka3 LOC100912585 Mgll Ltb4r Ffar2 Abhd12 Ffar3 Daglb Ltb4r2 Abhd6 Avp Dagla Brs3 Prkcq Prok2 Gcgr Prok1 Mchr1 Cck Tacr3 Tacr2 Bdkrb1 Bdkrb2 Trh Gng10 Nps P2ry6 Prkcd Lpar6 P2ry1 Kras Pik3r1 Gpr17 Pik3r2 Lpar4 Adra1a Tbxa2r Kalrn Adra1d Kng1 P2ry2 P2ry10 Kng2 Gnrhr Gnrh1 Cckbr Gast Uts2b Nmur2 Trpc3 Trpc7 Hras Nras Adrbk1 Sos1 Trpc6 Grb2 Tacr1 PI3K EVENTS IN ERBB4 SIGNALING%REACTOME%R-RNO-1250342.1 PI3K events in ERBB4 signaling Ereg Nrg1 Btc Pik3r1 Nrg3 Erbb4 Hbegf Nrg2 Nrg4 CGMP EFFECTS%REACTOME%R-RNO-418457.1 cGMP effects Pde1b Pde9a Pde5a Pde3b Pde3a Itpr1 Prkg2 Pde2a Cyct Mrvi1 Pde10a Pde11a INTERACTION BETWEEN PHLDA1 AND AURKA%REACTOME DATABASE ID RELEASE 66%10146219 Interaction between PHLDA1 and AURKA Phlda1 Aurka G-PROTEIN MEDIATED EVENTS%REACTOME%R-RNO-112040.1 G-protein mediated events Prkcd Plcb1 Gnai3 Gnal Plcb3 Gnat3 Pla2g4a Gnao1 Adcy3 Prkar2b Prkar2a Gnat2 Gnaz Pde1b Adcy8 Adcy9 Adcy5 Adcy4 Gnai2 Adcy7 Adcy6 Prkar1b Prkar1a Plcb4 Mapk1 Prkaca Prkacb Gnat1 Prkca Camk4 Adrbk1 Gnai1 ERBB2 REGULATES CELL MOTILITY%REACTOME DATABASE ID RELEASE 66%10146156 ERBB2 Regulates Cell Motility Ereg Nrg1 Btc LOC102552659 Erbb3 Erbb2 Nrg3 Egfr Hbegf Nrg4 Diaph1 Memo1 Rhoa Erbb4 Nrg2 S PHASE%REACTOME%R-RNO-69242.1 S Phase Rfc1 Psmc6 Rfc2 Psmb10 Psmb8 Pole2 Psmb9 Pole4 Psmb4 Psmb11 Psmb5 Psmf1 Psmb6 Psmd4 Mnat1 Psmb2 Rbx1 Psmd5 LOC100910252 Psmd8 Stag1 Psmd9 Psmb3 Psma8 Psmd11 Psmd12 Pds5b Prim2 Ccna2 Pds5a Ccne2 Pola2 Ccna1 Psmd13 Cdca5 Prim1 Ccne1 Rad21 Psmd14 Smc1a Stag2 Smc3 Esco2 Mcm2 Mcm4 Mcm3 Cdk2 Mcm5 Esco1 Rpa3 Mcm6 Pole Pcna Psmc3 Ccnh Mcm8 Mcm7 Orc4 Orc5 Orc6 Orc1 Orc2 Orc3 Rfc5 Rfc4 Cdc6 Rfc3 Ube2d1 Cdk4 Akt1 Rpa1 Ccnd1 Rpa2 Skp1 Lig1 Anapc7 Cdc26 Cdc27 Cdc23 Ube2c Skp2 Cdkn1a Cdkn1b Anapc16 Cdc16 Anapc4 Anapc2 Anapc1 Akt3 Slc25a16 Fen1 Cul1 Ptk6 Anapc11 Anapc15 Anapc10 Fzr1 Cks1l Cables1 Cks1b Akt2 G6pc Rb1 Psmb7 Psmb1 Gins3 Gins4 Gins1 Gins2 Psma5 LOC100911727 Cdk7 Cdt1 Pold2 Pold1 Psma2 Pold4 Psmc5 Psma1 Psmd2 Psma4 Cdc25b Psmc1 Cdc25a Psma3 Wee1 Psmc4 Psma6 Psmc2 Psme1 Psme2 Psmd1 Psmd7 Psmd3 Psmd6 IL-6-TYPE CYTOKINE RECEPTOR LIGAND INTERACTIONS%REACTOME DATABASE ID RELEASE 66%10145682 IL-6-type cytokine receptor ligand interactions Crlf1 Cntfr Lif Il6st Osm Jak1 Il11ra1 Lifr Clcf1 Il11 Il31ra Ctf1 Cntf Osmr Tyk2 VESICLE-MEDIATED TRANSPORT%REACTOME DATABASE ID RELEASE 66%10145300 Vesicle-mediated transport Kif21a Kif21b Kifc1 Kif3c Racgap1 Kif22 Kif3b Kif23 Kif18b Kifap3 Kif11 Egfr Kif12 Kif4a Kif6 Kif1a Kif1c Dnm2 Kif27 Kif9 Kif13b Cops8 Cops2 Nedd8 Akt1 Cops4 Cops6 Myo6 Cops3 Calr Kif20b Kif16b Kif26a Kif20a Kif26b Kif19 Galnt1 Galnt2 Sparc App Hbb-b1 Cd59 Arf6 Rab3ip Vamp8 Gdi2 Sar1b Stam2 Sh3gl2 Apob Sh3gl1 Apoe Sh3kbp1 Sh3gl3 Stam Rab4a LOC685953 Cd36 Ank1 Ctsc Ctsz Itsn1 Spta1 Dnm1 Dnm3 Sptbn1 Cops7b Cops7a Snap29 Pla2g6 Rab8a Tgfa Alpp Alpi Kif3a Col7a1 F8 Scfd1 Tsc1 Tsc2 Akt3 Pik3c2a Bnip1 Rabgap1 Madd Rin3 Clvs1 Snx18 Chmp2b Chmp2a Use1 Rgp1 Apol2 Hsp90b1 Hip1r Pla2g4a Colec12 LOC100909679 Ulk1 RGD1309808 Scgb3a2 Sbf2 Ap1m2 Cd163 Mvb12b Apol11a Mvb12a Apol3 Hpx Snx5 Stx16 Msr1 LOC100910885 Snx9 Fnbp1l Apol9a Snx2 Chmp4b Stx18 Chmp4c Golga5 Gapvd1 Golga1 Golga4 Dennd3 Acbd3 Sort1 Dnase2 Tbc1d10a Clint1 Tsg101 Tbc1d10b Cbl Yipf6 Ap4s1 Vta1 Hip1 Hps4 Tpd52 LOC100910792 Hps1 Mon1b Mon1a Cyth1 Cyth4 Cyth3 Cyth2 Trip11 Dennd1a Nbas Trappc12 Trappc11 Dennd1b Dctn1 Dctn2 Dctn3 Marco Hba1 Ambp Lrp1 Rab11a LOC287167 Csnk1d Arrb1 Arrb2 Adrbk1 Actr1a Klc1 Sec24a Sec24b Dync1li2 Copa Sec24d Sbf1 Dync1i2 Gja10 Gjd2 Syt1 Vamp2 Man1c1 Gjc1 Klc4 Man1a1 Cenpe Klc2 Klc3 Chmp4bl1 Cog4 Cttn Cog6 Gcc1 Cog8 Amph Cog3 Gja5 Rhobtb3 Pafah1b1 Cpd Cog1 Gja3 Cog2 Gja8 Usp6nl Gja4 Sec23ip Rala LOC100361515 Lman1l Gjb6 Scoc Cog7 Ap1b1 LOC102555167 Gjb2 Stx6 Dynll2 Vps37a Gjb3 Gjb4 Rab39a Vps37d Vps37c Stx4 Dync1i1 Rab11b Vps37b Gjc2 Tbc1d1 Tbc1d2 Ykt6 Tbc1d7 Sec24c Rabepk Gabarap Vps45 Bin1 Ubap1 Tmed7 Vps53 Tmed3 Vps52 Cux1 Tmed2 Ap4e1 Gjd4 Arfip2 Vps54 Rab6b Rab9a Ap4b1 Napg Ap1g2 Napb Ric1 Synj1 Napa Fnbp1 Vps4b Ccz1b Tpd52l1 St5 Snapin Scarb1 Rab3gap2 Tmed9 Dennd6b Dennd6a Apoa1 Ap3b1 Bicd2 Synj2 Vps25 Nsf Bicd1 Chmp5 Alppl2 Chmp7 Golim4 Bloc1s3 Snf8 Vps36 Chmp6 Rab8b Chmp3 Pum1 Arl1 Dennd5a Ap4m1 Bloc1s4 Gabarapl2 Agpat3 Bloc1s1 Bloc1s6 Rab3il1 LOC100910929 Chm Arfrp1 Trappc8 Dennd4a Dennd4b Arcn1 Pacsin2 Rab7b Pacsin3 Tbc1d13 Tbc1d16 Tbc1d15 Tbc1d17 Sytl1 Dennd2a Dennd2d Rab33a Dennd2c Rab33b Trappc13 Ap1s3 Ap1s1 Plin3 Ap1s2 Tbc1d25 Gak Pafah1b3 Tbc1d14 Trappc10 Rab35 Rab36 Ppp6c Trappc2l Rab43 Pip5k1c Rab21 Trappc6a Trappc6b Rab12 Rab13 Ankrd28 Rab32 Sec13 Rab30 Rab38 Rab1b Wasl Rab1a Tmem115 Ocrl Arfgap2 Stab2 Arpc4 Golgb1 Arpc3 Arfgap3 Kif2a Arfgap1 Kif2c Kif2b Kif18a Mcfd2 Preb Capzb Kif5b Kif5a Actr3 Sec31a Stx17 Dvl2 Gosr2 Gosr1 Zw10 Tmed10 Areg Stx5 Ftl1 Bet1 Arf5 Cnih1 Igf2r Arf4 Ctage5 Rab27a Gbf1 Cnih3 Cnih2 Ap2a2 Man2a1 Man2a2 Copz2 Copz1 Lman2 Sec16a Sec16b Lman1 Trappc2 Gja1 Trappc5 Src Rab27b RGD1561661 Rab3a Copb1 Wnt5a Cltc Cltb Rab7a Clta Tfg Fzd4 Ywhah Ywhag Sfn Ap2s1 Ywhaz Ywhab Ap2a1 Ywhaq Ywhae Trappc3 Ap2m1 LOC100910318 Rab5b Kdelr1 Rab5c Tbc1d20 Capza2 Capza3 Rab6a Kdelr2 Gjb1 Rab9b Ppp6r3 Ppp6r1 Trappc1 Kdelr3 Agtr1b Agtr1a Syt11 Aak1 Sgip1 Eps15l1 LOC100909548 Itsn2 Scarb2 LOC100910557 Necap1 Agfg1 Snap91 Ubqln2 Sptan1 Picalm Tgoln2 Ldlr Rab18 Tor1a Ston2 Tfrc RGD1307443 Rab10 Tf Chrm2 Rab14 Necap2 Cd4 Actr10 Tor1b Avp Dab2 Ston1 Dync1h1 Dync1li1 RGD1565355 Copg1 Dctn5 Dctn6 Ins1 Ins2 Dctn4 Folr1 Akt2 Uso1 Gorasp1 Ap1m1 LOC100360087 Txndc5 Actr2 Sec22b Cope Sec23a Sec22a Cd3g Slc2a8 Syt8 Cd3d Syt9 Arpc5 Syt2 Fcho2 Man1a2 Fcho1 M6pr Ldlrap1 Vamp4 Vamp3 Optn LOC100363782 Adrb2 Tbc1d10c Vamp7 Tacr1 Grb2 CONJUGATION OF PHENYLACETATE WITH GLUTAMINE%REACTOME DATABASE ID RELEASE 66%10145246 Conjugation of phenylacetate with glutamine Acsm1 SIGNALING BY FGFR1%REACTOME%R-RNO-5654736.1 Signaling by FGFR1 Src Kras Pik3r1 Frs3 Fgf23 Fgf22 Fgf4 Fgf1 Ppp2cb Fgf3 Ppp2ca Fgf6 Ppp2r1a Fgf5 Flrt1 Flrt2 Fgf20 Gab1 Mknk1 Fgf16 Fgf17 Fgfrl1 Fgf10 Fgf9 Fgfr2 Fgf2 Fgf7 Cbl Spry2 Fgf8 Fgfr3 Fgfr1 Mapk1 Fgfr4 Spred1 Ptpn11 Spred2 Plcg1 Fgf19 Hras Nras Frs2 Sos1 Shc1 Grb2 RNA POLYMERASE I CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 66%10144884 RNA Polymerase I Chain Elongation Gtf2h1 Gtf2h2 Mnat1 RGD1565904 Ubtf Polr1b Taf1d Polr2h Taf1c Cd3eap Polr2e Znrd1 Polr2f Polr1c Polr1a Polr2k Hist1h2bo Hist1h2bcl1 Hist2h3c2 LOC100912534 Hist1h2bk H3f3b Ccnh Gtf2h3 Gtf2h5 Tbp Gtf2h4 LOC100910200 H2afx Hist1h4b LOC684841 Hist1h2bh LOC100912290 Hist1h2ail1 Hist1h4m LOC102549173 LOC103690002 LOC100910152 LOC100912338 Hist1h3c H2afb3 Ercc3 Hist1h3f Hist2h4 LOC684819 Hist1h3a H2afj Hist2h2aa3 Hist1h2bq Hist2h2aa2 Ercc2 LOC100364835 LOC684762 Cdk7 Twistnb Polr1e Hist1h2bg LOC680097 LOC684797 LOC100912418 Hist1h2ba Hist3h2bb INTERLEUKIN-17 SIGNALING%REACTOME%R-RNO-448424.1 Interleukin-17 signaling Map2k7 Ripk2 Map2k6 Dusp3 Map2k4 Map3k8 Dusp4 Traf6 Cul1 Vrk3 Rps6ka2 Rps6ka1 Rps6ka3 Rps6ka5 LOC100912585 Tab1 Dusp7 Dusp6 Atf1 Atf2 Map3k7 Irak2 LOC100910771 Ube2n Il17c Il17a Jun Il17rc Ppp2cb Ppp2ca Skp1 Ppp2r1a Il25 Il17rb Il17ra Il17re Nfkb1 Mapk9 Mapk8 Fos Mapk7 Fbxw11 Chuk Ppp2r1b Mapkapk3 Btrc Mapkapk2 Mapk1 LOC100362142 Nod1 Nod2 Creb1 Tab2 Tab3 LOC100912618 Ube2v1 Ikbkb Mapk14 Tnip2 Mapk11 Mapk10 HDMS DEMETHYLATE HISTONES%REACTOME DATABASE ID RELEASE 66%10145998 HDMs demethylate histones Jmjd6 Hist1h4b LOC684841 LOC100912290 Hist1h2ail1 Hist1h4m LOC102549173 Hist1h3c Hist1h3f Hist2h4 Kdm2a LOC684819 Hist1h3a Kdm1b Kdm1a RGD1310212 LOC684762 Hist2h3c2 Kdm4b Kdm4a Kdm4d Kdm5a Kdm6b Kdm5d Kdm4dl1 Kdm8 Kdm3b Kdm3a LOC680097 LOC100912418 RNA POLYMERASE I TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 66%10144850 RNA Polymerase I Transcription Initiation Gtf2h1 Gtf2h2 Rbbp7 Ehmt2 Mnat1 RGD1565904 Ubtf Polr1b Hdac1 Ercc3 Taf1d Ercc6 Polr2h Taf1c Cd3eap Polr2e Znrd1 Polr2f Polr1c Polr1a Polr2k Ercc2 Ttf1 Rrn3 LOC100912534 Hdac2 Cdk7 Mbd3 Twistnb Hdac1l Chd3 Polr1e Chd4 Ccnh Mta3 Gtf2h3 Mta1 Mta2 Gatad2a Gtf2h5 Tbp Gtf2h4 LOC100910121 Gatad2b SCAVENGING OF HEME FROM PLASMA%REACTOME%R-RNO-2168880.1 Scavenging of heme from plasma Hba1 Ambp Lrp1 LOC287167 Apol2 RGD1309808 Apoa1 Cd163 Hbb-b1 Apol11a Apol3 Hpx LOC100910885 Apol9a MAP3K8 (TPL2)-DEPENDENT MAPK1 3 ACTIVATION%REACTOME DATABASE ID RELEASE 66%10145702 MAP3K8 (TPL2)-dependent MAPK1 3 activation Nfkb1 Skp1 Map3k8 Fbxw11 Chuk Ikbkb Tnip2 Btrc Cul1 SYNTHESIS OF 5-EICOSATETRAENOIC ACIDS%REACTOME%R-RNO-2142688.1 Synthesis of 5-eicosatetraenoic acids Alox5ap Pon3 Pon1 Pon2 Ltc4s Alox5 MYOGENESIS%REACTOME%R-RNO-525793.1 Myogenesis Cdh2 Ctnna1 Myf5 LOC100909750 Myf6 Mapk12 Tcf4 Cdon Myog Cdc42 Boc Myod1 Mef2c Spag9 Cdh15 Mapk14 Mef2a Mapk11 Abl1 CHONDROITIN SULFATE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 66%10145919 Chondroitin sulfate biosynthesis Vcan Ncan Bcan Chst7 Chpf2 Chst9 Chsy1 Chst12 Chst11 LOC100910284 Dcn Csgalnact1 Csgalnact2 Chst13 LOC102550316 Chst3 Cspg5 Cspg4 Chpf Chst15 SIGNALING BY LEPTIN%REACTOME DATABASE ID RELEASE 66%10145709 Signaling by Leptin Stat5a ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1%REACTOME DATABASE ID RELEASE 66%10145597 ADP signalling through P2Y purinoceptor 1 P2ry1 Src Gnb3 Gnb5 Gnb2 Gnb1 Gnaq Gna11 Gng13 Gna14 Gng12 Gna15 Gng11 Pla2g4a LOC100912034 Gnb4 Gng4 Mapk14 Gngt2 Gng5 Gngt1 Gng10 Gng8 Gng3 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE%REACTOME%R-RNO-2559586.1 DNA Damage Telomere Stress Induced Senescence Asf1a Ep400 LOC100911837 Rad50 Ubn1 Ccna2 Cabin1 Ccne2 Ccna1 Ccne1 Hira Atm Hist1h2bo Tinf2 Hist1h2bcl1 Hist1h2bk Cdk2 Terf2ip Nbn Mre11a LOC100910200 H2afx Hist1h4b Hist1h2bh Acd LOC100912290 Pot1b Hist1h4m LOC103690002 LOC100910152 Pot1 LOC100912338 H2afb3 Hist2h4 H2afj Hist2h2aa3 Hist1h2bq Hist2h2aa2 LOC100364835 Cdkn1a Terf1 LOC100910954 Cdkn1b Terf2 Hist1h2bg LOC680097 LOC684797 LOC100912418 Hist1h2ba Hist3h2bb FATTY ACYL-COA BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 66%10144901 Fatty acyl-CoA biosynthesis Tecr Tecrl LOC100365676 Hsd17b3 Acly Hsd17b8 LOC100912469 Acsbg1 Ppt1 Ppt2 Elovl1 Cbr4 Elovl5 Elovl2 Slc25a1 Elovl3 Elovl6 Acsbg2 Acsl3 Acsl1 Acsl6 Morc2b Acsl5 Acsl4 Hacd1 Scd4 Scd1 Scd2 Acsf3 Hacd4 Hacd3 Morc2 LOC681458 Hsd17b12 Fasn LOC100911941 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME%R-RNO-69580.1 p53-Dependent G1 S DNA damage checkpoint Psmc6 Psmb10 Mdm2 Psmb8 Psmb9 Psmb4 Psmb11 Psmb5 Psmf1 Psmb6 Psmd4 Psmb2 Psmd5 Psmd8 Psmd9 Psmb3 Psma8 Psmd11 Psmd12 Ccna2 Ccne2 Ccna1 Psmd13 Psmd14 Ccne1 Phf20 Atm Cdk2 Psmc3 Zfp385a Rfwd2 G6pc Psmb7 Psmb1 Psma5 Cdkn1a Cdkn1b LOC100910954 Mdm4 Chek2 Psma2 Psmc5 Psmd2 Psma1 Psma4 Psmc1 Psma3 Psmc4 Psmc2 Psma6 Psme1 Psmd1 Psme2 Psmd7 Psmd3 Psmd6 RSK ACTIVATION%REACTOME DATABASE ID RELEASE 66%10145660 RSK activation Rps6ka2 Rps6ka1 Rps6ka3 Rps6ka6 Pdpk1 Mapk1 PROCESSING OF CAPPED INTRONLESS PRE-MRNA%REACTOME%R-RNO-75067.1 Processing of Capped Intronless Pre-mRNA Ncbp2 Snrpf Ncbp1 Wdr33 Papola Cpsf7 Cpsf2 Cpsf3 Cpsf4 Pcf11 Cstf2t Fip1l1 Sympk Lsm10 Cstf1 Lsm11 Cpsf1 Nudt21 Slbp Zfp473 Snrpd3 Clp1 Cstf2 Snrpb DUAL INCISION IN GG-NER%REACTOME DATABASE ID RELEASE 66%10146140 Dual Incision in GG-NER Rfc1 Rfc2 Gtf2h1 Gtf2h2 Ddb2 Pole2 Pole4 Ddb1 Rbx1 Ercc5 Ercc3 Rpa1 Rpa2 Chd1l Ercc2 Ercc1 Parp2 Rpa3 Parp1 Pole Pold2 Pcna Pold1 Cul4b Pold4 Cul4a Xpa Gtf2h3 Rfc5 Rfc4 Rfc3 Gtf2h5 Gtf2h4 CONDENSATION OF PROPHASE CHROMOSOMES%REACTOME DATABASE ID RELEASE 66%10145955 Condensation of Prophase Chromosomes LOC100909949 LOC100910200 H2afx Mcph1 Hist1h4b RGD1563307 LOC684841 Hist1h2bh Rb1 LOC100912290 Hist1h2ail1 Hist1h4m LOC102549173 LOC103690002 LOC100910152 LOC100912338 Ncaph2 Hist1h3c H2afb3 Hist1h3f Hist2h4 LOC684819 Hist1h3a Smc4 H2afj Hist2h2aa3 Hist1h2bq Smc2 Hist2h2aa2 RGD1310212 LOC100364835 LOC684762 Hist1h2bo Hist1h2bcl1 Hist2h3c2 Hist1h2bk H3f3b Cdk1 Ncapg2 Hist1h2bg LOC680097 Setd8 LOC684797 LOC100912418 Hist1h2ba Hist3h2bb REGULATION OF TP53 ACTIVITY%REACTOME%R-RNO-5633007.1 Regulation of TP53 Activity Rhno1 Bard1 Rfc2 Wrn Topbp1 Rbbp8 Usp7 Rmi1 Mdm2 Rmi2 Banp Rad50 Cdk5 Csnk2a2 LOC364561 Pin1 Brd7 Csnk2a1 LOC685619 Ccna2 Ccna1 Rffl Plk3 Pml Ccng1 Prkab1 Tp73 Phf20 Atm Prkab2 Rictor Atrip Cdk2 Rpa3 Tp53bp2 Atp5c1 Rad1 Brca1 Taf7l Atr Blm Mapkapk5 Rad17 Setd8 Rfc5 Rad9a Tmem55b Rfc4 Pip4k2b Rfc3 Nbn Pip4k2c Rad9b Mre11a Ing2 Hus1 Akt1 Hdac1 Nuak1 Rpa1 Brpf3 Ppp2cb Ppp2ca Rpa2 Hipk2 Brpf1 Ppp2r1a Brd1 Taf7 Taf3 Taf6 Kat6a Taf5 Ing5 Mtor Tp53inp1 Prkag3 Tp63 Ppp2r1b Mlst8 Prkaa1 Prkaa2 Akt3 Slc25a16 Ssrp1 L3mbtl1 Mapk14 Mapk11 Map2k6 Dyrk2 Tp53rk Supt16h Prmt5 Aurka Hdac2 Mbd3 Chd3 Hdac1l Chd4 Aurkb Zfp385a Mta2 Gatad2a Tbp Meaf6 Gatad2b Akt2 LOC100909949 Smyd2 Rbbp7 Cdk5r1 Ehmt2 Ehmt1 Taf11 Ppp2r5c Taf2 Taf15 Taf13 Taf9 Taf12 Taf4b Noc2l Usp2 Csnk2b Tpx2 Daxx Pou4f2 LOC100910954 Cdk1 Hipk1 Mdm4 Chek2 Rnf34 Pdpk1 Taf10 Mapkap1 Sgk1 Ppp1r13b Ppp1r13l Ttc5 Taf9b MICROTUBULE-DEPENDENT TRAFFICKING OF CONNEXONS FROM GOLGI TO THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 66%10145301 Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane Gja1 ER TO GOLGI ANTEROGRADE TRANSPORT%REACTOME%R-RNO-199977.1 ER to Golgi Anterograde Transport Areg Stx5 Sec24a Bet1 Sec24b Arf5 Dync1li2 Copa Cnih1 Sec24d Dync1i2 Arf4 Ctage5 Gbf1 Cnih3 Cnih2 Cog4 Tgfa Cog6 Cog8 Cog3 Cog1 Cog2 Sec23ip Lman1l Cog7 LOC102555167 Dynll2 Copz2 Dync1i1 Copz1 Col7a1 Lman2 F8 Ykt6 Sec16a Scfd1 Sec24c Sec16b Lman1 Tmed7 Trappc2 Tmed3 Trappc5 Tmed2 Napg Napb Copb1 Napa Tmed9 Tfg Nsf Trappc3 LOC100910318 Kdelr1 Tbc1d20 Capza2 Capza3 Arcn1 Kdelr2 Ppp6r3 Trappc1 Ppp6r1 Kdelr3 Trappc10 LOC100910557 Sptan1 Ppp6c Actr10 Trappc2l Cd59 Dync1h1 Dync1li1 Trappc6a Trappc6b Copg1 Ankrd28 Sec13 Dctn5 Dctn6 Sar1b Ins1 Ins2 Rab1b Rab1a Dctn4 Tmem115 Folr1 Arfgap2 Dctn1 Ank1 Ctsc Dctn2 Uso1 Golgb1 Arfgap3 Gorasp1 Ctsz Dctn3 Arfgap1 Spta1 Mcfd2 Preb Capzb Sec22b Cope Sec23a Sptbn1 Sec31a Sec22a Stx17 Csnk1d Actr1a Gosr2 Gosr1 LOC100363782 Tmed10 IRON UPTAKE AND TRANSPORT%REACTOME DATABASE ID RELEASE 66%10145283 Iron uptake and transport Atp6v1d Ftl1 Slc11a2 Cul1 Heph Tfrc Tf Slc46a1 Atp6v1g1 Hmox1 Atp6v1g2 Ireb2 Aco1 Atp6v0a4 Atp6v1b2 Ftmt Atp6v0a2 Atp6v1h Atp6v1f Tfr2 Hfe Abcg2 Abcg3l3 Abcg3l1 Steap2 Cybrd1 LOC100911874 Cand1 Fbxl5 Atp6v0c Nedd8 RGD1561661 Tcirg1 Hmox2 Atp6v0d1 Atp6v1c2 Atp6v0d2 Skp1 Atp6v1a LOC100360087 Atp6v0e2 Atp6ap1 Atp6v0e1 Atp6v1g3 Atp6v1e1 Atp6v1e2 Atp6v1c1 Atp6v0a1 Slc40a1 Mcoln1 Cp CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION%REACTOME DATABASE ID RELEASE 66%10145415 Class I MHC mediated antigen processing & presentation Rnf41 Sec24a Sec24b Vhl Sec24d Asb18 Asb11 Asb12 Asb13 Rbx1 Asb14 Asb10 Socs3 Keap1 Uba7 Traf7 Asb15 Glmn Asb17 Uba5 Asb16 Hecw2 Mrc2 Ube2l6 Rbbp6 Mrc1 Ube3d Ube3b Trim11 Lrsam1 Ube3a Npepps Ube2o Rbck1 Ube2u Hectd3 Hectd1 RT1-A2 Rnf6 Ncf1 Erap1 RT1-A1 Ncf4 Rnf4 Cd207 B2m Tap1 Tap2 Traip Rnf25 Anapc13 Lnx1 Rnf19a Rnf19b Herc3 Ube2v2 Arih2 Herc6 Tapbp Stx4 Ube2n Tpp2 Ubox5 Ube2j2 Arel1 Ube2j1 Rnf182 Sec24c Rnf14 Ltn1 Cblb Sh3rf1 Pja1 Pja2 LOC100911393 Dtx3l Znrf2 Znrf1 Trim9 Blmh LOC100911400 Rnf115 Trim63 Ube2d1 Dzip3 Trip12 Ubr2 Trim71 Vprbp Trim69 Trim39 Ube4a Herc2 LOC100910646 Ufl1 Trim50 Ubac1 Ube2q1 Thop1 Rlim Ube2d3 Mex3c Rchy1 Mgrn1 Trim41 Hace1 Trim36 Trim37 Stub1 Anapc7 Fcgr1a Calr Cdc26 Cdc27 Fbxl22 Cdc23 Rnf144b Lrrc41 Ube2c Skp2 Fbxw10 Fbxw12 Cdc16 Anapc4 Anapc2 Anapc1 Trim21 Trim32 Cul1 Wwp1 Atg7 Canx Anapc11 Anapc10 Fzr1 Siah1 Siah2 Vamp8 Sec13 Sar1b LOC685953 Cd36 G6pc Klhl5 Cdc20 Psmb7 Psmb1 Klhl2 Fbxo2 Fbxo9 Fbxo7 Fbxo6 Psma5 Fbxo4 Ube2k Ube2h Ube2f Sec31a Psma2 Ube2a Psmd2 Klhl9 Psmc2 Psmd1 Lrr1 Psmd7 Psmd3 Psmd6 Psmc6 Psmb10 Psmb8 Psmb9 Rnf123 Psmb4 Psmb11 Fbxl19 Psmb5 Psmf1 Psmb6 Fbxl12 Fbxl13 Psmd4 Psmb2 Fbxl16 Fbxl15 Psmd5 Psmd8 Psmd9 Psmb3 Psma8 Ccnf Psmd11 Psmd12 Ube2e3 Psmd13 Psmd14 RT1-M3-1 Tceb2 Ube2z Tceb1 Cul2 Ube2s Psmc3 LOC100364500 RT1-S3 Fbxl4 Fbxl5 Fbxl8 RT1-CE2 Kctd7 RT1-CE3 RT1-CE4 RT1-CE7 Rnf7 RT1-CE5 RT1-CE10 Skp1 Kbtbd8 Kbtbd7 Kbtbd6 Kctd6 Ube2q2 Ube2r2 Fbxw11 Hspa5 Btrc LOC683761 Gan LOC100364956 LOC100362142 LOC100912618 Ube2v1 Fbxl18 Fbxl7 Asb5 Asb6 Asb7 Klhl41 Asb1 Asb3 Cdc34 Asb8 Klhl42 RT1-A Smurf1 Ube2m Fbxo41 Fbxo44 RGD1565355 Fbxo40 Cybb Cyba Wsb1 RT1-M2 Spsb2 RT1-M5 RT1-M4 Spsb1 Ubr4 Spsb4 Btbd1 Btbd6 Fbxo22 Ube2g2 Ube2g1 Klhl13 Fbxo30 Fbxo31 Klhl11 Fbxo32 Fbxo21 Klhl20 Zbtb16 Klhl25 Klhl21 Uba1 Klhl22 Fbxo10 Socs1 Fbxo15 Fbxo11 Sec22b Sec23a Fbxw2 Mylip Uba6 RT1-M6-1 Rnf34 Psmc5 Fbxw9 Psma1 Uba3 Psma4 RT1-M6-2 Psmc1 Fbxw5 Psma3 Fbxw4 Psmc4 Fbxw8 Psma6 Fbxw7 Psme1 Psme2 Vamp3 LOC100909844 POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%R-RNO-622327.1 Postsynaptic nicotinic acetylcholine receptors Chrnb4 Chrne Chrnd Chrna4 Chrna5 Chrna9 Chrna6 Chrnb2 Chrna7 Chrnb3 Chrna2 Chrna3 Chrna1 INTERLEUKIN-15 SIGNALING%REACTOME%R-RNO-8983432.1 Interleukin-15 signaling Stat5a Jak3 Il2rg Jak1 Stat3 Sos1 Sos2 Shc1 Il15 Grb2 Il2rb CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE%REACTOME%R-RNO-176407.1 Conversion from APC C:Cdc20 to APC C:Cdh1 in late anaphase Anapc7 Cdc26 Cdc14a Cdc27 Cdc23 Ube2c Ube2d1 Anapc16 Cdc16 Cdc20 Anapc4 Anapc2 Anapc1 Anapc11 Anapc15 Anapc10 Fzr1 ACTIVATED NTRK2 SIGNALS THROUGH FYN%REACTOME DATABASE ID RELEASE 66%10146323 Activated NTRK2 signals through FYN Gab1 Hgf Crk Crkl Dock7 Rac1 Grb2 LOC100911248 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF SATURATED FATTY ACIDS%REACTOME%R-RNO-77286.1 mitochondrial fatty acid beta-oxidation of saturated fatty acids LOC100911186 Echs1 Hadh Acadl Acads Hadha Hadhb Acadm Acadvl MET ACTIVATES RAP1 AND RAC1%REACTOME DATABASE ID RELEASE 66%10146252 MET activates RAP1 and RAC1 Gab1 Hgf Crk Rap1a Crkl Dock7 Rapgef1 Rac1 Grb2 LOC100911248 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION%REACTOME%R-RNO-156827.1 L13a-mediated translational silencing of Ceruloplasmin expression LOC100912571 Eif3l Eif2s3 Eif3m Eif3j Eif3k Rps20 Rps27l Eif3e Eif3f Eif3b Eif3a Eif3d Eif3c LOC100360573 Eif2s1 Eif2s2 Eif4g1 Rps4x LOC100359951 LOC100359593 LOC100359503 LOC100362640 Rpl13a Rps3 Rps15a Rps2 Rps13 Rps12 Pabpc2 Pabpc6 LOC100911372 LOC100361854 LOC684988 LOC103689992 Rps5 Rps7 Rps6 Eif3g Eif3h Eif4a2 LOC100362830 Eif1ax Eif4a1 LOC100363012 LOC680559 LOC100911110 LOC100362149 Rps16 LOC100911431 Pabpc1 Rps18 LOC100360679 Rps15 Eif4h Eif4b Rps3a HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME%R-RNO-5693579.1 Homologous DNA Pairing and Strand Exchange Rhno1 Rfc2 Bard1 Wrn Topbp1 Rbbp8 Rmi1 Rmi2 Rad51c LOC100911267 Hus1 Rad51d Rad51 Brca2 Rad50 Rpa1 Rpa2 Atm Atrip Rpa3 Xrcc3 Brca1 Rad1 Atr Blm Rad17 Slc25a16 Palb2 Rfc5 Xrcc2 Rfc4 Rad9a Nbn Rfc3 Rad9b Mre11a P75NTR SIGNALS VIA NF-KB%REACTOME%R-RNO-193639.1 p75NTR signals via NF-kB Ripk2 Prkci Nfkb1 Sqstm1 Ngf Nfkbia Ngfr Ikbkb Rela Myd88 Traf6 CELL-CELL COMMUNICATION%REACTOME DATABASE ID RELEASE 66%10145431 Cell-Cell communication Pvrl3 Crb3 PVR Pvrl4 Rsu1 Pvrl1 Cdh10 Kirrel Cdh11 LOC100911730 Kirrel3 Cdh17 Cdh13 Kirrel2 Cdh7 Cdh9 Fermt2 Flnc Inadl Cdh24 Pard6b Fyb Cd151 Nck1 Lamc2 Itgb4 Cadm3 Itga6 Cadm2 Mpp5 Ang2 Skap2 Flna Cd47 Fyn Pvrl2 Plec Wasl Cdh15 LOC100909879 Actn1 Lamb3 Nck2 Parvb Lims1 Arhgef6 Ilk Pard6a Ptk2b Dst F11r Jup Prkci LOC100360575 Sirpa Tyrobp Fblim1 Vasp Pard3 Cdh1 LOC100909977 Cdh2 Ctnna1 Sdk2 Ctnnd1 Cdh3 Pard6g Cdh5 Iqgap1 Cdh6 Col17a1 Grb2 RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASES%REACTOME DATABASE ID RELEASE 66%10145543 Receptor-type tyrosine-protein phosphatases Ptprd Il1rapl1 Slitrk6 Slitrk5 Slitrk3 Slitrk2 Slitrk1 Il1rap Ppfibp1 Ppfibp2 Ptprf Lrrc4b Ppfia1 Ppfia2 Ppfia3 Ppfia4 Ntrk3 SULFIDE OXIDATION TO SULFATE%REACTOME DATABASE ID RELEASE 66%10145889 Sulfide oxidation to sulfate Suox Sqrdl Ethe1 Tstd1 Slc25a10 SIGNALING BY EGFR%REACTOME DATABASE ID RELEASE 66%10144957 Signaling by EGFR Src Kras Arhgef7 Eps15l1 Pik3r1 Pxn Egfr Gab1 Csk Ptpn3 Spry2 Cbl Cdc42 Ptpn11 Stam2 Sh3gl2 Sh3gl1 Sh3kbp1 Plcg1 Ptprk Hras Spry1 Sh3gl3 Nras Sos1 Ptpn12 Lrig1 Shc1 Stam Grb2 INVADOPODIA FORMATION%REACTOME DATABASE ID RELEASE 66%10146271 Invadopodia formation Adam12 Adam19 Sh3pxd2a Adam15 P53-DEPENDENT G1 DNA DAMAGE RESPONSE%REACTOME%R-RNO-69563.1 p53-Dependent G1 DNA Damage Response Psmc6 Psmb10 Mdm2 Psmb8 Psmb9 Psmb4 Psmb11 Psmb5 Psmf1 Psmb6 Psmd4 Psmb2 Psmd5 Psmd8 Psmd9 Psmb3 Psma8 Psmd11 Psmd12 Ccna2 Ccne2 Ccna1 Psmd13 Psmd14 Ccne1 Phf20 Atm Cdk2 Psmc3 Zfp385a Rfwd2 G6pc Psmb7 Psmb1 Psma5 Cdkn1a Cdkn1b LOC100910954 Mdm4 Chek2 Psma2 Psmc5 Psmd2 Psma1 Psma4 Psmc1 Psma3 Psmc4 Psmc2 Psma6 Psme1 Psmd1 Psme2 Psmd7 Psmd3 Psmd6 METAL SEQUESTRATION BY ANTIMICROBIAL PROTEINS%REACTOME DATABASE ID RELEASE 66%10145804 Metal sequestration by antimicrobial proteins S100a8 Ltf SUMOYLATION OF IMMUNE RESPONSE PROTEINS%REACTOME%R-RNO-4755510.1 SUMOylation of immune response proteins Nfkb2 Nfkbia Sumo1 Pias3 Pias4 Ube2i Rela Sumo3 Ikbke Topors LYSINE CATABOLISM%REACTOME%R-RNO-71064.1 Lysine catabolism Pipox Aldh7a1 LOC100910122 Gcdh Ogdh Aadat Dlst Phykpl Hykk Dld ARL13B-MEDIATED CILIARY TRAFFICKING OF INPP5E%REACTOME DATABASE ID RELEASE 66%10146085 ARL13B-mediated ciliary trafficking of INPP5E Inpp5e Arl13b Pde6d TRANSPORT OF FATTY ACIDS%REACTOME%R-RNO-804914.1 Transport of fatty acids Apod Slc27a6 Vegp2 Lcn9 Lcn12 Lcn1 Slc27a4 Slc27a1 COPI-DEPENDENT GOLGI-TO-ER RETROGRADE TRAFFIC%REACTOME%R-RNO-6811434.1 COPI-dependent Golgi-to-ER retrograde traffic Kif21a Kif21b Kifc1 Kif3c Racgap1 Klc1 Bnip1 Arf5 Kif22 Kif3b Copa Kif23 Kif18b Kifap3 Kif11 Kif12 Kif4a Kif6 Kif1a Kif1c Arf4 Use1 Gbf1 Klc4 Kif27 Kif9 Kif13b Cenpe Klc2 Stx18 Klc3 Kif3a LOC102555167 Copg1 Copz2 Copz1 Rab1b Rab1a Nbas Tmed7 Arfgap2 Tmed3 Tmed2 Napg Arfgap3 Napb Copb1 Napa Kif2a Arfgap1 Kif2c Kif2b Tmed9 Kif18a Nsf Kif5b Kif5a Kdelr1 Sec22b Cope Arcn1 Kif20b Kif16b Kif26a Kif20a Kif26b Kif19 Kdelr2 Zw10 LOC100363782 Tmed10 Kdelr3 METABOLISM OF PROTEINS%REACTOME DATABASE ID RELEASE 66%10144825 Metabolism of proteins Usp7 Ddb2 Pias3 Pias1 Ffar1 Yy1 Ddb1 Rbx1 Actr8 Stag1 Rad21 Smc1a Stag2 Actl6a Smc3 Mcrs1 Cops8 Cops2 Actb Sumo1 Sumo3 Ino80 Pcna Cul4b Cul4a Ube2v2 Xpc Ube2n Ube2i Ruvbl1 Bche Hist1h2aa Cct6b Gnai3 Ache Ercc8 Rpa1 Gnao1 Cct6a Tcp1 Cct7 Cops4 Rgs7 Cct4 Cops6 Gnat2 Pdcl Gnaz Cct3 Cops3 Ripk2 Traf6 Cul1 Commd9 App Tab1 Rela Map3k7 Cd59 Ctsa Cct2 Stam2 Plaur Nfkbia Cct8 LOC100910771 Cst3 Muc20 Qsox1 Stam Rab4a Fcgr3a Ctsc C4a C4b Ctsz Mlec LOC100909666 LOC102549354 Psmb7 Psmb1 Ino80e Ino80d Nfrkb Psma5 Parp1 Rad23a Rad23b Cops7b Cops7a Psma2 Psmd2 Commd3 Klk13 Bst1 Psmc2 Psmd1 Psmd7 Ino80b Psmd3 Ino80c Psmd6 Mrps11 Mrps12 Mrps16 Mrps14 Mrps18b Mrps18c Mrps10 Mrps18a Ccdc22 Mrps33 Fbxl19 Mrps34 Gh1 Mrps21 Mrps35 Mrps17 Fbxl12 Mrps15 Fbxl13 Fbxl16 Mrps31 Fbxl15 Mrps30 Mrps24 Mrps23 Mrps22 mrpl9 Mrps28 Mrps27 Mrps26 Mrps25 LOC100911764 Mrpl4 Mrpl3 Mrpl2 Oxa1l Igfbp6 Mtrf1l Igfbp2 LOC367117 Tgfa Napsa Prnd Pappa2 Eif5a Pex2 Eif2ak3 Derl1 Klk1c12 Csf1 Mrrf Ttll10 Klk1c10 Clspn Rad18 Mrpl1 Mrpl13 Wfs1 Mrpl10 Pex5 Mrpl18 Ube2z Mrpl19 Dcun1d5 Mrps9 Dcun1d4 Mrps2 Dcun1d3 Mrps5 Ube2t Mrps7 Ube2s Ttll9 Mrpl36 LOC100909521 Mrpl37 Ttll4 Mrpl20 Ttll5 Ccdc59 Ttll3 Mrpl14 Ttll7 Mrpl16 Mrpl12 Ttll2 Mrpl15 Nae1 Fbxl4 Zdhhc2 Fbxl5 Mrpl41 F8 Mrpl35 Scfd1 Mrpl40 F7 Mrpl33 Tshb F9 Mrpl34 Ttll12 Mrpl38 Rbbp5 Fbxl8 Mrpl32 Mrpl27 LOC304903 Mrpl23 Mrpl28 Mrpl30 Mrpl21 Mrpl54 Lmcd1 Mrpl46 Mrpl55 Mrpl44 Mrpl43 Mrpl47 Mrpl49 Mrpl53 Mrpl48 Mrpl52 Gnat3 Mrpl51 Dpp4 Lep Mrpl50 Grp Gpr119 Ffar4 Skp1 Tnks Phc1 Phc2 Nfkb2 Fbxw11 Tfap2c Btrc Nod1 Nod2 Adora2a Adora2b Tnip2 Rxra Apol2 Prmt3 Hsp90b1 RGD1309808 Apol11a Apol3 LOC100910885 Apol9a Hist1h2bo Scmh1 Hist1h2bcl1 Cbx4 Hist1h2bk Cbx2 Cbx8 Bmi1 Hdac2 Rnf2 Usp13 Ring1 Phc3 Ogt Tnks2 Mta1 LOC100910717 LOC100910200 Hist1h4b Wdr5 Hist1h2bh Dnmt1 LOC100912290 Rbbp7 Hist1h4m LOC100912338 Dnmt3b Hist2h4 Hist2h2aa3 Hist1h2bq Hist2h2aa2 LOC100364835 Adgrf5 Sar1a Sftpa1 Pappa mrpl11 mrpl24 Chchd1 Igfals Dap3 Eral1 Gadd45gip1 Klk10 Klk1c6 Ict1 Ptcd3 Msrb2 Msrb3 Gfm2 Hist1h2bg Gfm1 Sftpb LOC680097 Msra LOC684797 Klk1c8 LOC100912418 Klk1c9 Hist1h2ba Klk1c2 Klk1c3 Mgat2 Mgat5 Mettl20 Mettl22 Sec24a Sec24b Copa Sec24d Mysm1 Asb18 Mgat3 Asb11 Asb12 Mgat1 Rgs9 Asb13 Asb14 Asb10 Keap1 Wdtc1 Fkbp8 Man1c1 Asb15 Asb17 Asb16 Adamts1 Man1a1 Adamts6 Adamts7 Uimc1 Adamts9 Sspo Cyr61 Cog4 Cog6 Cog8 Cog3 Ntng1 Ntng2 Cog1 Cog2 Chgb Igfbp1 Sec23ip Lman1l Igfbp5 Cog7 LOC102555167 Igfbp4 Alpl Kng1l1 Cand1 Afp Rab39a Gnat1 Mul1 Mfge8 Rab11b Ptp4a2 Cpm Thsd1 Ykt6 Sec24c Paf1 Igfbp7 Rfwd2 Notum Tmed7 Tmed3 LOC100911393 Tmed2 Eef2kmt Tex101 Aplp2 Rab6b Rab9a Napg Napb Napa Rtf1 Senp5 Mepe LOC100910849 Pigm Pigk Tmed9 Pigl Pigg LOC100911374 Pigh Nsf Dcaf11 Pigc Dcaf13 Pigb Piga Ankrd9 Dcaf10 Rab8b Pex14 Pex10 Pex13 Pex12 Fbxl22 Lrrc41 Ube2c Usp47 Usp48 Skp2 Fbxw10 Usp42 Chm Fbxw12 Ngly1 Fn3k Arcn1 Rab7b Becn1 Traf2 Pigw Pigv Pigy Pigx Rab33a Rab33b Pign Pigq Pigp Mxra8 Pigs Nucb1 Pigu Pigt Usp20 Usp26 Ggcx Usp21 Obsl1 Usp22 Rab2a Rab2b Trappc10 LOC100910410 Rab35 Rab34 Ly6g6c Rab36 Rabggta Usp19 Spon2 Spon1 Fn3krp Usp37 Il33 Ppp6c Manea Rab3c Rab3b Usp30 Vgf Neurl2 Trappc2l Rab43 Usp24 Usp25 Rab25 Stc2 Rab20 Rab21 Rab19 Prss41 Vdac1 Engase Rab23 Prss23 Prss21 Trappc6a Trappc6b Rab15 Rab12 Rab13 Ankrd28 Rabggtb Rab32 Rab30 Ly6g6d Usp14 Rab38 Usp18 Usp15 Rab1b Rab1a Usp11 Usp10 Tmem115 Ufd1l Sbspon Spaca4 Arfgap2 Dph1 Dcaf8 Atxn3 Dph3 Gpihbp1 Golgb1 Dph2 Klhl5 Arfgap3 Atxn7 Dcaf4 Sparcl1 Arfgap1 Dph5 Dph6 Ubxn1 Otoa LOC690251 LOC100910472 Penk Mcfd2 Preb Chst10 Kng1 Capzb Vdac2 Klhl2 Foxo4 Fbxo2 Eva1a Kng2 Fbxo9 Fbxo7 Cdh2 Rwdd3 Fbxo6 Fbxo4 Proz Cul9 Dcun1d2 Ube2k Plet1 Ube2h Ube2f Sec31a Ube2a Stx17 Pomt2 Pomgnt2 Dcaf7 Pomt1 Pros1 Klhl9 Dcaf5 Dcaf6 Dda1 Bglap Lrr1 Dhps Gosr2 Gosr1 Tmed10 Pomgnt1 Hrc LOC100912571 Wdr20 Eif3l Areg Eif2s3 Stx5 Eif3m Bet1 Eif3j Arf5 Eif4ebp1 Etfb Cnih1 Eif3k Shisa5 Fuca2 Rps20 Rnf123 Rps27l Pofut2 Eif3e Mfi2 Eif3f Wdr48 Eif2b1 Izumo1r Eif3b Bre Eif3a Cish Eif3d Arf4 Eif3c Bpifb2 Ctage5 Asgr1 Large Brcc3 Gyltl1b Rab27a Ccnf Psmd11 Gbf1 Psmd12 Ube2e3 Ccna2 LOC100360573 Ctr9 Ccna1 Eif2s1 Cnih3 Psmd13 Eif2s2 Cnih2 Psmd14 Eif4g1 Dtl Asgr2 Amtn Rps4x Rab7l1 LOC100359951 Wdr61 LOC100359593 Commd7 Eif5 Commd2 Cfp LOC100359503 Commd1 LOC100362640 Rpl13a Man2a1 Fut8 Rps3 Rps15a Serpind1 Man2a2 Rps2 Sprn Rps13 Sema5b Tceb2 Rps12 Mgat4b Pabpc2 Tceb1 Commd4 Pabpc6 Cul2 Commd5 Hif1a LOC100911372 Mgat4a LOC100361854 Commd6 LOC684988 Rnf152 LOC103689992 Psmc3 Enam Rps5 Fem1b Rps7 Fem1a Eif2b5 Serpinc1 Rps6 Epas1 Ptrh2 Eif2b3 Tada3 Eif2b4 Hif3a Copz2 Eif3g Copz1 Eif3h Bcl10 Eif4a2 Reck LOC100362830 Lman2 Eif1ax Sec16a Eif4a1 Sec16b LOC100363012 Lman1 LOC680559 LOC102554393 LOC100911110 Rnf181 LOC100362149 Trappc2 Kctd7 Trappc5 Calu Bmp15 Rnf7 Kin Cd109 Rab27b Babam1 Fem1c Rab3a Josd2 Copb1 Josd1 Suds3 Opcml Eif5a2 Chst8 Rab7a Thy1 Tfg Tada2b Ly6e Ly6d Psca Ly6h Kbtbd8 Otulin Rab22a Rab4b Kbtbd7 Kbtbd6 Mme Gpld1 Neu1 Trappc3 Kctd6 Mettl21a Arsi Pcsk9 LOC100910318 Arse Ube2q2 Hltf Arsg Ube2r2 Rab5b Kdelr1 Amelx Rab5c Rce1 Arsk Tbc1d20 Sts Capza2 Capza3 LOC100910143 Rab6a Commd10 Sumf2 Gan Sumf1 B3galnt2 Atp6ap2 Tecta Thsd7a Vnn3 Fam20c Usp3 Usp4 Usp5 Stambpl1 Kdelr2 Tmem132a LOC100911959 Thsd7b Lgals1 Rab9b Ppp6r3 Trappc1 Ppp6r1 Kdelr3 Tectb Art3 Fam20a Art4 Adamts13 Apc Otub1 Adamts15 Otud3 Ide Otud7b Hist2h2ab Adamts19 LOC100910557 Adamts16 Adamts17 Pomk Ambn Sptan1 Gas6 Vcp Adamts12 Asb5 Rab18 Asb6 Asb7 Msln Klhl41 Rab10 Asb1 Rab14 Asb3 Vnn1 Cdc34 Asb8 Rab24 Zranb1 Rtn4rl2 Actr10 Ripk1 Ifih1 Vcpip1 Klhl42 Tnip1 Gpaa1 Arsa RGD1565607 Otub2 LOC100911993 Rtn4rl1 Tnfaip3 Dync1h1 Lypd5 Tdg Nr5a2 Lypd8 Lypd1 Lypd6b Lypd2 Lypd3 Lypd4 Apeh LOC102553119 Dync1li1 LOC689730 Fbxo41 Thbs2 Bmyc Fbxo44 Polb Fbxo40 Wsb2 Copg1 Wsb1 Spsb3 Dctn5 Dctn6 Esr1 Spsb2 Adamtsl2 Spsb1 Adamtsl3 Gata3 Shprh Rnf20 Ddx5 Adamtsl4 Folr2 Nrip1 Dctn4 Rab3d Spsb4 Pgr Folr1 Ncoa1 Scg2 Btbd1 Btbd6 Fbxo22 Ube2g2 Ube2g1 Dohh Uso1 Scg3 Il6 Klhl13 Fbxo30 Gorasp1 Fbxo31 Klhl11 Fbxo32 Fbxo21 LOC100910107 St8sia1 Ddx58 Klhl20 Alg1 Rps16 Cntn4 Gfpt2 Cntn3 Nus1 Cntn5 Alg2 Pgap1 Dolpp1 Sae1 Gfpt1 St8sia3 Rnf40 LOC100911431 Fam175b Alg6 Pabpc1 Rcn1 Alg3 Zbtb16 Alg9 Rps18 Klhl25 LOC100360679 Alg8 Klhl21 Rps15 Uba1 Eif4h Klhl22 Eif4b Uba2 Rps3a Fbxo10 Renbp St3gal5 Rab40c Mpi Usp2 Rab40b Csnk2b Icmt Pgm3 Fam175a Adra2a Pmm2 Fbxo15 Gnai2 Alg14 Tulp4 Pmm1 Dnajc3 Fbxo11 Adra2c Alg12 Slc35a1 Sec22b Daxx LOC100910954 St8sia5 Cope St6galnac1 Sec23a Cdk1 Mdm4 St6galnac2 C3 Fbxw2 Uba6 Nudt14 LOC501189 Taf10 St8sia4 Gp2 LOC100910177 Sec22a Dolk Senp2 St6gal1 Uba3 Fbxw9 St6gal2 Nub1 Amdhd2 Senp1 St6galnac4 Rhoa Fbxw5 St6galnac3 Eef2 Fbxw4 Nagk Fbxw8 Gne Fbxw7 Mpdu1 Man1a2 Dpagt1 LOC103690024 St6galnac6 Xpnpep2 Gnai1 Gnpnat1 LOC100912059 Dpm3 Ckap4 Serpina10 Dpm2 LOC100363782 Dpm1 Usp17l5 Uap1 Taf9b Trim27 Mdm2 Vhl Pcsk1 Mboat4 Ghrl Socs5 Socs3 Leo1 Vwa1 Stambp Commd8 Socs6 Pias4 Pml Pias2 Brca1 Blm Mdc1 Zfp131 Pcgf2 Hdac4 Uhrf2 Foxl2 Satb2 Satb1 Topors Usp8 Thra Thrb Fuom Nsmce1 Smad3 Slc35c1 Ing2 Nsmce2 Smad2 Mbd1 Nr1h3 Nedd8 Nr1h2 Top1 Safb Usp9x Park7 Ube2d1 Smc6 Tp53bp1 Fuk Smc5 Nr5a1 Tsta3 Rora Gmds LOC100911225 Nr1i2 Rad52 Fpgt Mitf Herc2 Hdac1 Xrcc4 LOC100911274 Timp1 Ube2d3 Cma1 Edem3 Calr Man1b1 Rnf139 Ganab Edem2 Uggt1 Trim13 Dmp1 Rnf5 Prkcsh B3gnt6 Abca3 Galntl5 Galnt6 Galnt5 B3gnt8 Muc1 Plg B3gnt5 Chst4 Galnt1 Ceacam10 Galnt7 Galnt3 Galnt2 Mmp1 Mmp2 Canx Lamc1 Rnf103 March6 Fbn1 Ceacam1 Ikbke Fgg Siah2 Traf3 Thbs1 Sar1b Apob Fga Apoe Apoa2 Lamb1 Dag1 Lamb2 Gng10 Spp1 Ank1 Nop58 Adamts4 Adamts3 Adamts5 Sema5a Ctsd Creb3l3 Crebrf Ctsg Spta1 Creb3 Fn1 P4hb Adamts14 Nans Sptbn1 Npl Dhdds Cmas Ltbp1 Nanp Sec11c MGC109340 Pla2g7 Spcs2 Sec11a Bard1 Pten Csf2ra Csf2rb Lhb Rab8a Ccp110 Furin Alpp Alpi Mvd Bmp4 Col7a1 F2 Cga Gzmf Ace3 Cpa3 Npepo Neu4 Ero1l Neu2 Gzmn Ero1lb Inha Exoc3 Inhbc Neu3 LOC100910060 Exoc2 Exoc1 Exoc6 Exoc5 Exoc8 Exoc7 Cpb2 Cpb1 Ren Fshb Agt Srd5a3 Ace LOC691670 Sin3a Txn1 Rraga Galnt9 LOC102550196 Gcnt1 A4gnt Muc13 C1galt1 Muc15 C1galt1c1 Galnt16 Galnt18 Galnt14 Galnt15 Galnt12 Galnt13 B3gntl1 Galnt10 Tgfbr1 Ube2m Hdac1l Dctn1 Cdc73 Dctn2 Dctn3 Os9 Usp33 Slc17a5 Rab11a Arrb1 Csnk1d Arrb2 Atf6 Actr1a Sel1l Nr1h4 Mbtps1 Dync1li2 Mbtps2 Kat2a Dync1i2 Csnk2a2 Csnk2a1 Dynll2 Tomm70a Dync1i1 Tomm20 Birc5 Pomc Nup88 Apoa1 Hipk2 B3gnt4 B3gnt7 Alppl2 B3gnt1 B3gnt2 B3gnt3 Nup85 Nlrp3 Rae1 Pnpla2 Glb1 St3gal2 St3gal3 St3gal1 St3gal4 St3gal6 Nup93 Nup98 Nup107 LOC100363239 Sec61g Ern1 LOC100361694 Nup210 LOC100911750 Ppara Nupl2 Nupl1 Ttf1 Cdca8 Gip Rangap1 B4galt1 Aurkb B4galt3 Sec13 Sec63 B4galt2 Serp1 B4galt6 Sec61a1 Sec62 B4galt4 Sec61a2 B4galt5 Sec61b Asna1 Nup205 Slc30a5 Slc30a6 Slc30a8 Incenp G6pc Ktn1 Nup155 Cdc20 Men1 Slc34a1 LOC100911615 Nup153 Vcan Tpr Arsb Mkl1 Nup54 Pom121 Nup62 Cp Psmc6 Psmb10 Nup43 Nup133 Psmb8 Psmb9 Psmb4 Psmb11 Aaas Psmb5 Psmf1 Psmb6 Psmd4 Psmb2 Psmd5 Psmd8 Npap60 Psmd9 Psmb3 Nup35 Psma8 Nup37 Sdc2 Gspt1 Rhot1 Gspt2 Uchl3 Bap1 Senp8 RGD1561252 Asxl2 Foxk2 Uchl5 Ranbp2 Adrm1 Uchl1 Mat2b N6amt1 Trmt112 Etf1 Gnb3 Gnb5 Gnb2 Gnb1 Gng13 Gng12 Gng11 LOC100912034 Gnb4 Gcg Gng4 Gngt2 Gng5 Gngt1 Gng8 Gng3 Fbxl18 Fbxl7 Tgoln2 Fgf23 Tf Fstl1 Fstl3 Igf2 Igf1 Chrdl1 Ins1 Ins2 Inhba Birc3 Birc2 Cyld P2ry2 Psmc5 Psma1 Psma4 Psmc1 Cdc25a Psma3 Psmc4 Ppa2 Psma6 Psme1 Psme2 LOC100909844 Adrb2 IRF3-MEDIATED INDUCTION OF TYPE I IFN%REACTOME DATABASE ID RELEASE 66%10145930 IRF3-mediated induction of type I IFN Nlrp4 Dtx4 Tbk1 Nlrp4a Irf3 Tmem173 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION%REACTOME%R-RNO-2565942.1 Regulation of PLK1 Activity at G2 M Transition Bora Cul1 Dync1i2 Cep57 Rab8a LOC691918 Haus3 Ninl Aurka Akap9 Ccp110 Dync1h1 Pafah1b1 Ppp1r12a LOC103692716 Ppp1cb Ajuba Dctn1 Cntrl Dctn2 Cep76 Pcm1 Cep78 LOC100911033 Cep164 Dctn3 Ofd1 Cep41 Sdccag8 Tubb5 Prkar2b Cenpj Skp1 Ywhag Ppp2r1a Plk4 Ywhae LOC100912076 Tubg2 Haus2 Haus1 Haus5 Alms1 Haus4 Clasp1 Fbxw11 Odf2 Tubb4a Cdk1 Nek2l1 Btrc Ssna1 Mapre1 Tubg1 Cep63 Prkaca Csnk1d Cep131 Tuba4a Cep250 Cep135 Csnk1e Ckap5 Cdk5rap2 Pcnt Nek2 Cep72 Sfi1 Cep70 Actr1a Optn Nedd1 INTERLEUKIN-33 SIGNALING%REACTOME%R-RNO-9014843.1 Interleukin-33 signaling Il33 Il1rl1 Il1rap MHC CLASS II ANTIGEN PRESENTATION%REACTOME DATABASE ID RELEASE 66%10145936 MHC class II antigen presentation Kif3c Racgap1 Sec24a Klc1 Kif22 Sec24b Dync1li2 Kif3b Sec24d Kif23 Kifap3 Kif11 Kif4a Dync1i2 RGD1308751 Dnm2 Klc4 Cenpe Klc2 Klc3 Ap2a2 Cts8l1 Kif3a Ap1b1 Dynll2 Dync1i1 Sec24c Cltc Rab7a Clta RT1-Ba RT1-Bb RT1-Da RT1-Db2 Ap2s1 RT1-Db1 LOC688090 Ap2a1 Ap2m1 MGC114246 Capza2 Capza3 Testin Kif26a Kif20a Ap1s3 Ap1s1 Ap1s2 Lgmn Canx Ap1m2 Actr10 Dync1h1 Ctsa Dync1li1 Actr1b LOC100364523 Sec13 Dctn5 Dctn6 Sar1b Sh3gl2 Dctn4 Dctn1 Ctsc Dctn2 Dctn3 Kif2a Kif2c Kif2b Ctsd RT1-DMa Ctsb Ap1m1 RT1-DMb Cd74 Kif18a Ctsl Lag3 Ctsm Rilp Ctsj Ifi30 RGD1564657 Capzb Ctsk Kif5b LOC100909593 Ctsq LOC100909630 Ctsr RT1-DOb Kif5a RT1-DOa Ctse Ctsf Dnm1 Dnm3 Sec23a Sec31a Cts8 Cts7 RGD1564827 Actr1a DNA REPLICATION%REACTOME%R-RNO-69306.1 DNA Replication Rfc1 Psmc6 Rfc2 Psmb10 Psmb8 Pole2 Psmb9 Pole4 Psmb4 Psmb11 Psmb5 Psmf1 Psmb6 Psmd4 Psmb2 Rbx1 Psmd5 Psmd8 Psmd9 Psmb3 Psma8 Psmd11 Psmd12 Prim2 Ccna2 Ccne2 Pola2 Ccna1 Psmd13 Prim1 Ccne1 Psmd14 Mcm2 Mcm4 Mcm3 Cdk2 Mcm5 Rpa3 Mcm6 Pole Mcm10 Pcna Psmc3 Mcm8 Mcm7 Orc4 Orc5 Orc6 Orc1 Orc2 Orc3 Rfc5 Cdc7 Rfc4 Rfc3 Cdc6 Cdc45 Ube2d1 Rpa1 Rpa2 Skp1 Lig1 Anapc7 Cdc26 Cdc27 Cdc23 Ube2c Skp2 Anapc16 Cdc16 Anapc4 Anapc2 Anapc1 Slc25a16 Fen1 Cul1 Anapc11 Anapc15 Anapc10 Fzr1 Gmnn G6pc E2f2 Psmb7 Psmb1 Gins3 Gins4 Gins1 Gins2 E2f1 Psma5 E2f3 LOC100911727 Cdt1 Pold2 Psma2 Pold1 Pold4 Psmc5 Psma1 Psmd2 Psma4 Psmc1 Psma3 Psmc4 Psma6 Psmc2 Psme1 Psmd1 Psme2 Psmd7 Psmd3 Psmd6 ARYL HYDROCARBON RECEPTOR SIGNALLING%REACTOME DATABASE ID RELEASE 66%10146264 Aryl hydrocarbon receptor signalling Ptges3l1 Aip Hsp90ab1 Arnt2 Arnt Ptges3 Ahr Ahrr ISG15 ANTIVIRAL MECHANISM%REACTOME DATABASE ID RELEASE 66%10145800 ISG15 antiviral mechanism LOC100912571 Stat1 Irf3 Jak1 Eif4e2 Arih1 Ddx58 Uba7 LOC100911431 Ube2l6 Eif4g1 Eif4a3 Eif4g2 Eif4g3 Flnb Isg15 Trim25 Eif2ak2 Usp18 Ube2n Ppm1b Plcg1 Eif4e3 Eif4a2 Mx1 Mx2 Eif4a1 LOC680559 GENERIC TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 66%10144749 Generic Transcription Pathway Rfc2 Gtf2h1 Gtf2h2 Usp7 Mdm2 Nrbf2 Zfp28-ps1 Zfp445 Banp Zfhx3 Notch3 Rarg Esr2 Mnat1 Rbx1 RGD1565904 Nr2c2ap Cdk5 RGD1308751 Hnf4a Polr2g Hnf4g Polr2h Zfp473 Polr2e Nr4a3 Polr2f Nr4a1 Polr2j Nr4a2 Polr2k Polr2d LOC685619 Polr2i Zfp212 Polr2b Pml Zfp418 Polr2c Zfp213 Polr2a Actl6a Zfp867 Esrra Esrrb LOC100912534 Triap1 Elf1 Ell Sumo1 Elf2 Rpa3 Tp53bp2 Nr6a1 Nr2c2 Nr2c1 Atp5c1 Cited2 Zkscan1 Tcea1 Zfp263 Pcna Zfp266 Taf7l Brca1 Zfp496 Ccnh Blm LOC102555919 Mapkapk5 Rara Pcgf2 Rarb Yap1 Zfp498 Tead2 Pidd1 Tead1 Nr2e1 Ppm1d Ube2i Hdac4 Zfp483 Nr2f6 Rbm14 Gtf2h3 Rfc5 Nr2f1 LOC100911677 Rfc4 Zfp287 Rfc3 LOC691135 Sox9 Nr2e3 Gtf2h5 Thra Zfp282 Gtf2h4 Thrb Zfp786 Smad3 Actl6b Ccnt2 Ing2 Zfp770 Smad2 Smarce1 Zfp771 Zfp354c Nr1h3 Nr1h2 Pbrm1 Tceb3 Arid1b Zfp354a Arid1a Usp9x Sp1 Zfp791 Ube2d1 Skil Zfpm1 Rbl1 Nr5a1 Cdk4 Ncor2 Cdk9 Akt1 Rora Nr1i2 E2f4 Smarcd1 LOC102554302 Hdac1 Tgif2 Smarcd2 Ercc3 Tgif1 LOC100911274 Smarcd3 Atp1b4 Nuak1 Rpa1 Brpf3 Trim33 Foxp3 Ccnd1 Rpa2 Ccnk Brpf1 Ube2d3 LOC100911822 LOC100363472 Brd1 Taf7 Nr1i3 Wwtr1 Tfdp1 Taf3 Ercc2 Kat6a Taf6 Tfdp2 Taf5 Stub1 Ing5 Zfp202 Tp53inp1 MGC114246 Zfp839 Zfp420 LOC100911519 Tbx5 Runx2 Rxrg Tp63 Nrbp1 Yaf2 Zfp426 LOC102553866 Nelfe Nelfa Nelfb Testin Znf740 Cradd Bnip3l Slc25a16 Znf750 Ssrp1 L3mbtl1 L3mbtl2 Zfp775 Zfp777 Dek Map2k6 Zfp746 Zfp583 Zfp180 Zfp189 Dyrk2 Epc1 Cul1 Zfp804b Zfp703 Tp53rk LOC100911224 Zfp707 Zfp710 Supt16h Zfp711 Krba1 Zfp566 Zfp169 Zfp167 Zfp383 Zfp37 Zfp113 Zfp110 Zfp382 Zfp112 Zfp46 Zfp398 Zfp111 Trim28 Zfp394 Zfp2 LOC100364523 Zfp317 Zfp597 Zfp74 LOC501406 Zfp9 Zfp1 Zfp84 Rslcan18 Serpinb13 Zfp90 Zim1 Zfp641 Zfp647 LOC102549842 LOC102555083 LOC102546354 Auts2 Pax5 LOC102553962 Mga Zfp668 Cdk5r1 Zfp667 Psmb7 Prelid1 Psmb1 Taf11 Ctsl Taf15 Zfp248 Esrrg Ctsm Taf13 Ctsj Taf12 RGD1564657 Ctsk Taf4b Ctsq Ctsr Nr0b1 Noc2l Nr0b2 Psma5 Max Parp1 Supt4h1 Pou4f2 Cdk7 Zfp286a Hipk1 E2f6 Zfp324 Psma2 Psmd2 Brd2 Zfp697 Zfp612 Cts8 Zfp692 Cts7 Zfp691 Psmc2 Ppp1r13b Psmd1 LOC100910137 Psmd7 RGD1564827 Ppp1r13l Zfp606 Ttc5 Zfp688 Psmd3 Rorb Psmd6 Rhno1 Bard1 Wrn Topbp1 Rbbp8 Rmi1 Rmi2 Rad50 Lhb Gata2 LOC364561 LOC100911167 Pin1 Brd7 Sesn2 Tal1 Plk2 Ldb1 Txnrd1 Ccne2 Sesn1 Plk3 RragB Ccne1 Prkab1 Tp73 Sesn3 Gata1 Prkab2 Lmo2 Gsr Lmo1 Atrip Cts8l1 Cdk2 E2f7 E2f8 Btg2 Cnot6l Cnot11 Rad1 Atr Rad17 Tgfb1 Setd8 Rad9a Tmem55b Nbn Pip4k2b Cga Rad9b Pip4k2c Mre11a Rbbp5 Hus1 Tfap2a Tnks1bp1 Cnot8 Rqcd1 Ppp2cb Cnot3 Ppp2ca Cnot1 Skp1 Cnot2 Ppp2r1a Cnot7 Cnot4 Phc1 Phc2 Mtor Prdx1 Ddit4 Rheb Prkag3 Rptor Lamtor4 LOC502894 Tfap2b Tsc1 Tfap2c Lamtor5 Sin3a Txn1 Ppp2r1b Sin3b Mlst8 Prkaa1 Tsc2 Tfap2d Rraga Tfap2e Prkaa2 Rragc Akt3 Rragd Slc38a9 Mapk14 Mapk11 Rxra Pparg Prmt5 Prmt6 Hist1h2bo Scmh1 Hist1h2bcl1 Hist2h3c2 Cbx4 Hist1h2bk Cbx2 H3f3b Smurf1 Cbx8 Cbx6 Bmi1 Hdac2 Rnf2 Mbd3 E2f5 Ring1 Smarca4 Hdac1l Chd3 Smarca2 Snw1 Chd4 Phc3 LOC100911617 Arid2 Zfp385a Smarcc1 Smarcc2 Smarcb1 Mta2 Gatad2a Cdk6 Gatad2b Meaf6 LOC100909949 Eed Atad2 LOC100910200 Ccnd3 H2afx Hist1h4b Wdr5 Kmt2a LOC684841 Smyd2 Hist1h2bh LOC100912290 Rbbp7 Hist1h2ail1 Hist1h4m LOC102549173 LOC103690002 Ehmt2 LOC100910152 Ehmt1 LOC100912338 Hist1h3c H2afb3 Hist1h3f Hist2h4 Cenpj LOC684819 Hist1h3a H2afj Hist2h2aa3 Hist1h2bq Hist2h2aa2 Ash2l LOC100364835 LOC684762 Dpy30 Cited4 Yeats4 Tcf7 Hist1h2bg Ezh2 Lef1 Tcf7l1 LOC680097 LOC684797 LOC100912418 Hist1h2ba Hist3h2bb Nr1h4 Maml1 Rbpj Kat2a Rbpjl2 Csnk2a2 Csnk2a1 LOC100909750 Vdr Hipk2 Supt5h Skp2 Cdkn1a Cdkn1b Chm Gadd45a Bax Rabggta Ppara Ppard Aurka Cdc25c Aurkb Rabggtb Abl1 G6pc Men1 Ppp2r5c Gpi Pdpk1 Psmc6 Psmb10 Psmb8 Psmb9 Psmb4 Psmb11 Psmb5 Psmf1 Psmb6 Psmd4 Psmb2 Psmd5 Psmd8 Psmd9 Psmb3 Psma8 Psmd11 Psmd12 Ccna2 Ccna1 Rffl Psmd13 Ccng1 Psmd14 Phf20 Atm Rictor Tceb2 Tceb1 Psmc3 Src Ywhah Ywhag Sfn Ywhaz Ywhab Ywhaq Ywhae Med1 Lamtor3 Cited1 Nr5a2 Gtf2f1 Gtf2f2 Lamtor2 Lamtor1 Bmyc Prmt1 Esr1 Cbfb Gata3 Crebbp Pgr Tbp Runx1 Akt2 Nr1d1 Notch1 Pcgf6 Nr1d2 Kras Pcgf5 Notch4 Cdk12 Taf2 Zfp14 Slmo1 Taf9 RGD1562871 Zfp12 Cdk13 Casp2 Zfp13 Zfp28 Zfp18 Csnk2b Usp2 Tpx2 Daxx LOC100910954 Cdk1 Mdm4 Chek2 Taf10 Rnf34 Mapkap1 Sgk1 Psmc5 Psma1 Psma4 Psmc1 Ptpn11 Psma3 Notch2 Psmc4 Psma6 Psme1 Psme2 Taf9b ACYL CHAIN REMODELING OF CL%REACTOME%R-RNO-1482798.1 Acyl chain remodeling of CL Pla2g4a Taz Lclat1 Hadha Hadhb VOLTAGE GATED POTASSIUM CHANNELS%REACTOME DATABASE ID RELEASE 66%10145837 Voltage gated Potassium channels Kcng4 Kcng3 Kcnq2 Kcna7 Kcnb2 Kcns2 Kcnq3 Kcns1 Kcnh4 Kcnh3 Kcnh2 Kcnab3 Kcna10 Kcnf1 Kcnh6 Kcnh5 Kcnd3 Kcnd1 Kcna1 Kcnab2 Kcna2 Kcna5 Kcnc3 Kcnh1 Kcna4 Kcnc2 Kcnv2 Kcnv1 Kcns3 Kcnq1 ADHERENS JUNCTIONS INTERACTIONS%REACTOME DATABASE ID RELEASE 66%10145606 Adherens junctions interactions Pvrl3 Pvrl4 PVR Cdh2 Ctnna1 Pvrl1 Cdh10 Cdh11 Pvrl2 Cdh17 Cdh13 Cdh7 Cdh9 Cdh24 Jup Cadm3 Cadm2 Ctnnd1 Cdh3 Cdh5 Cdh15 Ang2 Cdh6 Cdh1 BETA-OXIDATION OF PRISTANOYL-COA%REACTOME%R-RNO-389887.1 Beta-oxidation of pristanoyl-CoA Amacr Acot8 Acox3 Crat Hsd17b4 Acox2 Crot Acoxl SEMA4D IN SEMAPHORIN SIGNALING%REACTOME%R-RNO-400685.1 Sema4D in semaphorin signaling Rras Rock1 LOC102552659 Erbb2 Rac1 Arhgap35 Rhoa Sema4d Plxnb1 Rock2 Rnd1 Arhgef11 Rhob Rhoc TRANSCRIPTIONAL REGULATION BY E2F6%REACTOME%R-RNO-8953750.1 Transcriptional Regulation by E2F6 Eed Pcgf6 Max Bmi1 Rnf2 Mga Rbbp7 Yaf2 Ring1 E2f6 Ehmt2 Phc3 Epc1 Ehmt1 LOC100911274 Pcgf2 RGD1562871 Ezh2 L3mbtl2 Tfdp1 Phc1 Tfdp2 SUMOYLATION OF DNA DAMAGE RESPONSE AND REPAIR PROTEINS%REACTOME%R-RNO-3108214.1 SUMOylation of DNA damage response and repair proteins Nup93 Nup43 Nup98 Nup133 Nup107 Pias1 Aaas Nup210 Npap60 Stag1 Nup35 Nup37 Nupl2 Pias4 Pml Rad21 Nupl1 Pias2 Smc1a Stag2 Smc3 Tdg Scmh1 Cbx4 Cbx2 Cbx8 Sumo1 Bmi1 Rnf2 Sumo3 Ring1 Phc3 Brca1 Blm Mdc1 Pcgf2 Xpc Ube2i Nup205 Ranbp2 Nsmce1 Nsmce2 Nup155 Smc6 Smc5 Rad52 Herc2 Xrcc4 LOC100911274 Nup88 Rpa1 Nup85 Phc1 Nup153 Phc2 Parp1 Tpr Rae1 Nup54 Pom121 Nup62 ERK1 ERK2 PATHWAY%REACTOME DATABASE ID RELEASE 66%10144961 ERK1 ERK2 pathway Ereg Nrg1 Btc LOC102552659 Erbb3 Erbb2 Nrg3 Egfr Hbegf Nrg4 Fyn Ptk2 Nrg2 Shc2 Ranbp9 Pdgfa Pdgfb Tln1 Vwf Apbb1ip Rasa1 Dlg4 Grin2d Camk2g Grin2b Grin1 Nefl Rasgrf1 Dusp4 Dlg1 Dlg2 Frs3 Dlg3 Camk2d Actn2 Camk2a Dusp7 Dusp6 Fgb Ret Fgg LOC100909468 Hgf Fga Gdnf Map2k2 Pspn Ppp2r5e Il2rg G6pc Pdgfra Pdgfrb Psmb7 Psmb1 Ppp2r5c Spta1 Lrrc7 Ppp2r5a Gfra4 Gfra3 Ppp2r5b Gfra2 Pbp2 Fn1 Artn Dusp9 Dusp2 Shc3 Dusp5 Nrtn Rasal3 Psma5 Ptpra Csk Rasal1 Rasal2 Rasgrp1 Rap1a Pebp1 Ncam1 Rasgrp4 Sptbn1 Rasgrp3 Pea15 Dusp1 Mark3 Psma2 Araf Rasa4 Psmd2 Il5 Spred1 Spred2 Rasgef1a Il2 Psmc2 Rasa2 Rasa3 Itga2b Il2ra Csf2 Psmd1 Il3ra Psmd7 Nf1 Iqgap1 Kit Syngap1 Psmd3 Kitlg Il2rb Psmd6 Dusp16 Psmc6 Map3k11 Csf2ra Psmb10 Csf2rb Ksr1 Rapgef2 Psmb8 Wdr83 Psmb9 Ksr2 Raf1 Psmb4 Ppp5c Psmb11 Psmb5 Il17rd Psmf1 Il5ra Psmb6 Cnksr1 Psmd4 Cnksr2 Psmb2 Dusp10 Psmd5 Paqr3 Psmd8 Psmd9 Psmb3 Psma8 Psmd11 Psmd12 Psmd13 Psmd14 Fgf2 Psmc3 Src Ppp2cb Ppp2ca Ppp2r1a Ywhab Ppp2r1b Mapk1 Jak3 Jak1 Vcl Sptan1 Fgf23 Fgf22 Fgf4 Fgf1 Fgf3 Fgf6 Fgf5 Lamtor3 Fgf20 Fgf16 Lamtor2 Fgf17 Irs2 Fgf10 Fgf9 Fgfr2 Fgf7 Fgf8 Fgfr3 Fgfr1 Fgfr4 Fgf19 Erbb4 Irs1 Frs2 Tyk2 Kras Il6st Il6 Cdk1 Psmc5 Arrb1 Psma1 Tek Psma4 Psmc1 Arrb2 Ptpn11 Psma3 Psmc4 Psma6 Lat Psme1 Angpt1 Hras Psme2 Nras Sos1 Shc1 Grb2 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE%REACTOME DATABASE ID RELEASE 66%10145153 Toll Like Receptor 9 (TLR9) Cascade Map2k7 Ripk2 Map2k6 Ager Dusp3 Map2k4 Map3k8 Dusp4 Peli3 Nfkbib LOC100912399 Peli2 Map3k1 Traf6 Cul1 Vrk3 Rps6ka2 Rps6ka1 App Rps6ka3 Rps6ka5 Tlr9 LOC100912585 Tab1 Dusp7 Dusp6 Rela Atf1 Atf2 Map3k7 Peli1 Irak2 Nfkbia LOC100910771 Ube2n Rbsn Jun Ppp2cb Ppp2ca Skp1 Ppp2r1a Nfkb2 Nfkb1 Mapk9 Tlr7 Mapk8 Tlr8 Fos S100b Irak4 Pik3c3 Mapk7 Dhx9 Fbxw11 Chuk Ppp2r1b Ecsit Mapkapk3 Pik3r4 Eea1 Btrc Mapkapk2 Dhx36 Mapk1 Nkiras1 LOC100362142 Nod1 Nod2 Nkiras2 Creb1 Tab2 Tab3 LOC100912618 Ube2v1 Ikbkb Mapk14 Myd88 Tnip2 Mapk11 Mapk10 GLUCAGON SIGNALING IN METABOLIC REGULATION%REACTOME DATABASE ID RELEASE 66%10145003 Glucagon signaling in metabolic regulation Prkaca Prkacb Prkar2b Prkar2a Prkar1b Gcgr Gcg Prkar1a ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION%REACTOME DATABASE ID RELEASE 66%10145786 Antigen processing: Ubiquitination & Proteasome degradation Rnf41 Vhl Asb18 Asb11 Asb12 Rbx1 Asb13 Asb14 Asb10 Socs3 Uba7 Keap1 Traf7 Glmn Asb15 Uba5 Asb17 Hecw2 Asb16 Ube2l6 Rbbp6 Ube3d Ube3b Trim11 Lrsam1 Ube3a Npepps Ube2o Rbck1 Ube2u Hectd3 Hectd1 Rnf6 Rnf4 Traip Rnf25 Anapc13 Lnx1 Rnf19a Rnf19b Herc3 Arih2 Ube2v2 Herc6 Ube2n Tpp2 Ubox5 Ube2j2 Arel1 Ube2j1 Rnf182 Rnf14 Ltn1 Cblb Sh3rf1 Pja1 Pja2 LOC100911393 Dtx3l Znrf2 Znrf1 Trim9 Blmh LOC100911400 Rnf115 Trim63 Ube2d1 Dzip3 Trip12 Ubr2 Trim71 Vprbp Trim69 Trim39 Ube4a Herc2 LOC100910646 Ufl1 Trim50 Ubac1 Ube2q1 Thop1 Rlim Ube2d3 Mex3c Rchy1 Mgrn1 Trim41 Hace1 Trim36 Trim37 Stub1 Anapc7 Cdc26 Cdc27 Fbxl22 Cdc23 Rnf144b Lrrc41 Ube2c Skp2 Fbxw10 Fbxw12 Cdc16 Anapc4 Anapc2 Anapc1 Trim21 Trim32 Cul1 Wwp1 Atg7 Anapc11 Anapc10 Fzr1 Siah1 Siah2 G6pc Klhl5 Cdc20 Psmb7 Psmb1 Klhl2 Fbxo2 Fbxo9 Fbxo7 Fbxo6 Psma5 Fbxo4 Ube2k Ube2h Ube2f Ube2a Psma2 Psmd2 Klhl9 Psmc2 Psmd1 Lrr1 Psmd7 Psmd3 Psmd6 Psmc6 Psmb10 Psmb8 Psmb9 Rnf123 Psmb4 Psmb11 Fbxl19 Psmb5 Psmf1 Fbxl12 Psmb6 Fbxl13 Psmd4 Psmb2 Fbxl16 Fbxl15 Psmd5 Psmd8 Psmd9 Psmb3 Psma8 Psmd11 Ccnf Psmd12 Ube2e3 Psmd13 Psmd14 Tceb2 Ube2z Tceb1 Cul2 Ube2s Psmc3 Fbxl4 Fbxl5 Fbxl8 Kctd7 Rnf7 Skp1 Kbtbd8 Kbtbd7 Kbtbd6 Kctd6 Ube2q2 Ube2r2 Fbxw11 Btrc Gan LOC100362142 LOC100912618 Ube2v1 Fbxl18 Fbxl7 Asb5 Asb6 Asb7 Klhl41 Asb1 Asb3 Cdc34 Asb8 Klhl42 Smurf1 Ube2m Fbxo41 Fbxo44 Fbxo40 Wsb1 Spsb2 Spsb1 Ubr4 Spsb4 Btbd1 Btbd6 Fbxo22 Ube2g2 Ube2g1 Klhl13 Fbxo30 Fbxo31 Klhl11 Fbxo32 Fbxo21 Klhl20 Zbtb16 Klhl25 Klhl21 Uba1 Klhl22 Fbxo10 Socs1 Fbxo15 Fbxo11 Fbxw2 Mylip Uba6 Rnf34 Psmc5 Fbxw9 Uba3 Psma1 Psma4 Psmc1 Fbxw5 Psma3 Fbxw4 Psmc4 Fbxw8 Psma6 Fbxw7 Psme1 Psme2 LOC100909844 GAP JUNCTION TRAFFICKING%REACTOME%R-RNO-190828.1 Gap junction trafficking Gja1 Gja5 Dnm1 Gjd4 Gja3 Gja8 Gja4 Gjb6 Gjb2 Cltc Gja10 Cltb Gjd2 Gjb3 Clta Dnm2 Gjb4 Gjc1 Gjc2 Gjb1 Myo6 Dab2 Ap2m1 REGULATION OF PTEN STABILITY AND ACTIVITY%REACTOME DATABASE ID RELEASE 66%10146185 Regulation of PTEN stability and activity Psmc6 Pten Psmb10 Trim27 Otud3 Psmb8 Psmb9 Psmb4 Psmb11 Psmb5 Psmf1 Psmb6 Psmd4 Psmb2 Psmd5 Psmd8 Csnk2a2 Psmd9 Psmb3 Psma8 Psmd11 Csnk2a1 Psmd12 Psmd13 Psmd14 Usp13 Prex2 Psmc3 Tnks2 LOC100910717 Akt2 G6pc Akt1 Frk Psmb7 Psmb1 Xiap Tnks Stub1 Csnk2b Psma5 Psma2 Psmc5 Akt3 Psmd2 Psma1 Psma4 Psmc1 Psma3 Psmc4 Psmc2 Psma6 Psme1 Psmd1 Psme2 Psmd7 Psmd3 Psmd6 EXTRINSIC PATHWAY OF FIBRIN CLOT FORMATION%REACTOME DATABASE ID RELEASE 66%10145054 Extrinsic Pathway of Fibrin Clot Formation Tfpi F3 F7 F9 MITOCHONDRIAL TRANSLATION ELONGATION%REACTOME DATABASE ID RELEASE 66%10146063 Mitochondrial translation elongation Mrps11 Mrps12 Mrps16 Mrps14 Mrps18b Mrps18c Mrps10 Mrps18a Mrps33 Mrps34 Mrps21 Mrps35 Mrps17 Mrps15 Mrps31 Mrps30 Mrps24 Mrps23 Mrps22 mrpl9 Mrps28 Mrps27 Mrps26 Mrps25 Mrpl4 Mrpl3 Mrpl2 Oxa1l LOC367117 Mrpl1 Mrpl13 Mrpl10 Mrpl18 Mrpl19 Mrps9 Mrps2 Mrps5 Mrps7 Mrpl36 Mrpl37 Mrpl20 Mrpl14 Mrpl16 Mrpl12 Mrpl15 Mrpl41 Mrpl35 Mrpl40 Mrpl33 Mrpl34 Mrpl38 Mrpl32 Mrpl27 Mrpl23 Mrpl28 Mrpl30 Mrpl21 Mrpl54 Mrpl46 Mrpl55 Mrpl44 Mrpl43 Mrpl47 Mrpl49 Mrpl53 Mrpl48 Mrpl52 Mrpl51 Mrpl50 mrpl11 mrpl24 Chchd1 Dap3 Eral1 Gadd45gip1 Ict1 Ptcd3 Gfm1 TRANSFER OF LPS FROM LBP CARRIER TO CD14%REACTOME%R-RNO-166020.1 Transfer of LPS from LBP carrier to CD14 Cd14 Lbp ENOS ACTIVATION AND REGULATION%REACTOME%R-RNO-203765.1 eNOS activation and regulation Nosip Nos3 Dnm2 Ddah2 Zdhhc21 Nostrin Ddah1 Wasl Spr Cygb LOC103692716 Akt1 G2 M TRANSITION%REACTOME%R-RNO-69275.1 G2 M Transition Psmc6 Psmb10 Psmb8 Psmb9 Psmb4 Psmb11 Psmb5 Psmf1 Psmb6 Mnat1 Psmd4 Rbx1 Psmb2 Dync1i2 Psmd5 Psmd8 Cep57 Psmd9 Psmb3 Rab8a Psma8 LOC691918 Psmd11 Psmd12 Haus3 Ccna2 Ccna1 Psmd13 Ninl Psmd14 Akap9 Ccp110 Cdk2 Pafah1b1 Ppp1r12a Psmc3 Ccnh Ajuba Hsp90ab1 Tubb5 Ppp2cb Ppp2ca Ywhag Skp1 Ppp2r1a Ywhae Fbxw11 Cdkn1a Ppp2r1b Nek2l1 Btrc Prkaca Nek2 Ppp2r3b Bora Fbxl18 Fkbpl Fbxl7 Ppme1 Foxm1 Cul1 Lcmt1 Tubgcp2 Aurka Dync1h1 Cdc25c LOC103692716 Ppp1cb Xpo1 Dctn1 Cntrl Dctn2 Cep76 G6pc Pcm1 Cep78 LOC100911033 Cep164 Dctn3 Ofd1 Cep41 Psmb7 Sdccag8 Psmb1 Prkar2b Cenpj Plk4 LOC100912076 Tubg2 Haus2 Psma5 Haus1 Haus5 Tpx2 Alms1 Cdk11b Clasp1 Haus4 Odf2 Cdk7 LOC100910954 Tubb4a Cdk1 Ssna1 Tubg1 Mapre1 Psma2 Cep63 Csnk1d Psmc5 Gtse1 Cep131 Psmd2 Psma1 Phlda1 Tuba4a Psma4 Cdc25b Cep250 Psmc1 Cdc25a Psma3 Cep135 Wee1 Csnk1e Psmc4 Pkmyt1 Cdk5rap2 Psma6 Psmc2 Ckap5 Ppp2r2a Psme1 Nme7 Tubgcp5 Pcnt Tubgcp6 Psme2 Psmd1 Cep72 Tubgcp3 Sfi1 Psmd7 Tubgcp4 Cep70 Optn Actr1a LOC100909844 Mzt1 Nedd1 Psmd3 Mzt2b Psmd6 SYNTHESIS OF GDP-MANNOSE%REACTOME DATABASE ID RELEASE 66%10145672 Synthesis of GDP-mannose Mpi Pmm2 Pmm1 PI-3K CASCADE:FGFR3%REACTOME DATABASE ID RELEASE 66%10145257 PI-3K cascade:FGFR3 Gab1 Fgf16 Fgf17 Pik3r1 Fgf9 Fgf2 Fgf8 Fgfr3 Fgf23 Fgf4 Ptpn11 Fgf1 Fgf5 Frs2 Fgf20 Grb2 PAOS OXIDISE POLYAMINES TO AMINES%REACTOME DATABASE ID RELEASE 66%10145060 PAOs oxidise polyamines to amines Smox RGD1564480 Paox DOWNREGULATION OF ERBB4 SIGNALING%REACTOME DATABASE ID RELEASE 66%10145828 Downregulation of ERBB4 signaling Wwp1 Erbb4 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION%REACTOME%R-RNO-2029482.1 Regulation of actin dynamics for phagocytic cup formation Abi1 Myo1c Abi2 Potef Rac1 Myh9 Nck1 Arpc1b LOC100909750 Actb Cyfip1 Brk1 LOC103692716 Baiap2 Limk1 Nf2 Pak1 Wasl Nckap1l Ptk2 Actg1 Cyfip2 Abl1 Nckap1 Fcgr3a Wasf1 Arpc4 LOC100909609 Hsp90ab1 Arpc3 Nckipsd LOC100361457 Myo9b Vav2 Vav1 Actr3 Was Fcgr1a Cd247 Actr2 Myo10 Crk Vav3 Mapk1 Cdc42 LOC100911597 Cd3g Arpc5 Dock1 Fcgr2b Wipf1 LOC103693683 Wipf2 Elmo2 Wipf3 Fcgr2a Syk Grb2 TERMINAL PATHWAY OF COMPLEMENT%REACTOME DATABASE ID RELEASE 66%10145210 Terminal pathway of complement Clu C6 C8g C8a C8b REGULATION OF RUNX1 EXPRESSION AND ACTIVITY%REACTOME%R-RNO-8934593.1 Regulation of RUNX1 Expression and Activity Ccnd3 Ptpn11 Cbfb Ccnd1 Pml Cdk6 Runx1 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%R-RNO-2514859.1 Inactivation, recovery and regulation of the phototransduction cascade Cnga1 Gucy2f Pde6b Rcvrn Gucy2d Pde6a Rgs9 RGD1560341 Gnb5 Guca1b Ppef1 Metap2 Metap1 Gnat1 Nmt1 Guca1a Cngb1 Rgs9bp Fnta Nmt2 Sag Grk4 Grk1 Gngt1 Fntb Pde6g GENERATION OF SECOND MESSENGER MOLECULES%REACTOME DATABASE ID RELEASE 66%10145400 Generation of second messenger molecules Was Cd247 Cd101 Fyb Cd3g Cd3e Nck1 Cd3d Pak2 RT1-Ba Pak3 RT1-Bb Lat Pak1 RT1-Da Cd4 Plcg1 RT1-Db2 RT1-Db1 LOC688090 Lcp2 Itk MITOCHONDRIAL TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 66%10145119 Mitochondrial transcription termination Mterf CLEAVAGE OF THE DAMAGED PYRIMIDINE%REACTOME%R-RNO-110329.1 Cleavage of the damaged pyrimidine Tdg Neil1 Ogg1 Neil2 Mbd4 Smug1 Ung Nthl1 INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME DATABASE ID RELEASE 66%10145016 Intrinsic Pathway for Apoptosis Gzmbl1 Gzmc LOC100911163 Gzmbl2 Gzmbl3 Bak1 Gzmb LOC691695 Diablo Ywhah Bcl2l11 Ywhag Sfn Ywhaz Ppp3r1 Bcl2 Bid LOC100360940 Xiap Ywhab Ywhaq Ywhae Casp8 Bad Mapk8 Dynll2 Nmt1 Bax Bmf Pmaip1 PHASE 3 - RAPID REPOLARISATION%REACTOME%R-RNO-5576890.1 Phase 3 - rapid repolarisation Kcne3 Kcnq1 Kcne5 Kcnh2 Akap9 Kcne1 Kcne2 Kcne4 TRANSLESION SYNTHESIS BY POLH%REACTOME%R-RNO-110320.1 Translesion Synthesis by POLH Rfc1 Rfc2 Rpa3 Polh Pcna Vcp Rpa1 Rpa2 Rchy1 Sprtn Rfc5 Nploc4 Rfc4 Ufd1l Rfc3 PLATELET CALCIUM HOMEOSTASIS%REACTOME%R-RNO-418360.1 Platelet calcium homeostasis P2rx1 Atp2b4 Sri Atp2b2 Atp2b1 Slc8a3 P2rx2 P2rx3 Itpr1 P2rx5 P2rx6 Itpr3 P2rx4 Trpc3 Trpc7 Atp2a2 Slc8a2 Trpc6 Slc8a1 P2rx7 Atp2a3 NUCLEAR ENVELOPE REASSEMBLY%REACTOME%R-RNO-2995410.1 Nuclear Envelope Reassembly Vrk2 Vrk1 DAG AND IP3 SIGNALING%REACTOME%R-RNO-1489509.1 DAG and IP3 signaling Prkcd Pde1b Adcy8 Adcy9 Adcy5 Adcy4 Adcy7 Adcy6 Prkar1b Prkar1a Prkaca Prkacb Adcy3 Prkar2b Prkca Prkar2a Camk4 Adrbk1 ION INFLUX EFFLUX AT HOST-PATHOGEN INTERFACE%REACTOME%R-RNO-6803544.1 Ion influx efflux at host-pathogen interface Slc11a1 Pdzd11 Atp7a Atox1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER%REACTOME DATABASE ID RELEASE 66%10146143 Gap-filling DNA repair synthesis and ligation in GG-NER Rfc1 Rfc2 Rpa3 Pole2 Pole4 Pole Pold2 Pcna Pold1 Pold4 Rpa1 Rpa2 Rfc5 Rfc4 Rfc3 PYRIMIDINE CATABOLISM%REACTOME%R-RNO-73621.1 Pyrimidine catabolism Nt5c1a Nt5c Nt5c3a Nt5e Upp1 Upb1 Upp2 Nt5m Tymp Dpys GLYCOLYSIS%REACTOME DATABASE ID RELEASE 66%10144768 Glycolysis Nup93 Nup43 Nup133 Nup98 LOC100911625 Nup107 Eno3 Aaas Gapdhs Eno1 Eno2 Nup210 Aldoa Npap60 Nup35 Aldob Aldoc Nup37 Nupl2 Gckr Nupl1 Pklr Pfkfb3 Pfkfb4 Pfkfb1 Pfkfb2 Pfkl Pfkp Nup205 Aldoart2 Ranbp2 Hk2 Pgm2l1 Nup155 Tpi1 Gpi Nup88 Nup85 Pgk2 Nup153 Pgk1 Pkm Tpr Pgam1 Pgam2 Rae1 Gnpda2 Adpgk Nup54 Pom121 Bpgm Nup62 MOLECULES ASSOCIATED WITH ELASTIC FIBRES%REACTOME DATABASE ID RELEASE 66%10145882 Molecules associated with elastic fibres Itgb6 Itgb8 LOC102553715 Vtn Itga8 Efemp1 Efemp2 Fbln2 LOC100911714 Fbln1 Fbln5 Mfap2 Gdf5 Ltbp3 Ltbp2 Mfap5 Ltbp4 Mfap4 Ltbp1 Bmp2 Bmp7 Bmp4 Mfap3 Tgfb2 Tgfb1 Tgfb3 OXIDATIVE DEMETHYLATION OF DNA%REACTOME DATABASE ID RELEASE 66%10146048 Oxidative demethylation of DNA Tdg TRANSPORT OF CONNEXONS TO THE PLASMA MEMBRANE%REACTOME%R-RNO-190872.1 Transport of connexons to the plasma membrane Gja1 Gjb2 RRNA PROCESSING%REACTOME DATABASE ID RELEASE 66%10146163 rRNA processing Rps20 Rps27l LOC100360573 Rps4x LOC100359951 LOC100359593 LOC100359503 LOC100362640 Rps3 Rps15a Rps2 Rps13 Rps12 LOC100911372 LOC100361854 LOC684988 LOC103689992 Rps5 Rps7 Rps6 LOC100362830 LOC100363012 LOC100362149 Exosc3 Exosc9 LOC100359574 Exosc2 Exosc1 Exosc4 Exosc7 Exosc5 Dcaf13 Tbl3 Tsr1 Emg1 Wdr75 Wdr18 Wdr43 Wdr46 Nhp2l1 C1d Nob1 Fcf1 Wdr12 Senp3 Wdr36 Ebna1bp2 Rpp25 Riok3 Riok1 Utp14a Bysl NEWGENE_1564769 Rpp21 Pdcd11 Rpp40 Skiv2l2 Heatr1 Riok2 Rpp38 Rrp36 Rpp30 Bop1 Utp20 Dhx37 Utp18 Gnl3 Utp15 Utp11l Pno1 Pwp2 Wbscr22 Mphosph6 Imp4 Imp3 Nop56 Tex10 Utp6 Rcl1 Nol6 Utp3 Ncl Nop14 Xrn2 Rrp9 Rrp7a Pes1 Exosc10 Krr1 Nol9 Mphosph10 LOC100910568 Rpp14 Cirh1a Diexf Nop58 Ddx52 Rps16 Ltv1 Wdr3 Noc4l Ddx49 Ddx47 Las1l Fbl Rps18 LOC100360679 Rps15 Ddx21 Rps3a Csnk1d Csnk1e AGMATINE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 66%10145466 Agmatine biosynthesis Agmat MUSCARINIC ACETYLCHOLINE RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145559 Muscarinic acetylcholine receptors Chrm1 Chrm5 Chrm2 Chrm4 Chrm3 ACTIVATED NTRK2 SIGNALS THROUGH PLCG1%REACTOME%R-RNO-9026527.1 Activated NTRK2 signals through PLCG1 Ntf4 Ntrk2 Bdnf Plcg1 KETONE BODY METABOLISM%REACTOME DATABASE ID RELEASE 66%10144854 Ketone body metabolism Hmgcll1 Aacs Bdh2 Acat1 Hmgcs2 Hmgcl Acss3 Oxct1 TYPE II NA+ PI COTRANSPORTERS%REACTOME DATABASE ID RELEASE 66%10145628 Type II Na+ Pi cotransporters Slc34a1 Slc34a3 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY%REACTOME DATABASE ID RELEASE 66%10145795 TRAF3-dependent IRF activation pathway Irf3 Crebbp ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX%REACTOME%R-RNO-68867.1 Assembly of the pre-replicative complex Psmc6 Psmb10 Psmb8 Psmb9 Psmb4 Psmb11 Psmb5 Psmf1 Psmb6 Psmd4 Psmb2 Psmd5 Psmd8 Psmd9 Psmb3 Psma8 Psmd11 Psmd12 Psmd13 Psmd14 Mcm2 Mcm4 Mcm3 Mcm5 Mcm6 Psmc3 Mcm8 Mcm7 Orc4 Orc5 Orc6 Orc1 Orc2 Orc3 Cdc6 Gmnn G6pc E2f2 Psmb7 Psmb1 E2f1 Psma5 E2f3 Cdt1 Psma2 Psmc5 Psmd2 Psma1 Psma4 Psmc1 Psma3 Psmc4 Psmc2 Psma6 Psme1 Psme2 Psmd1 Psmd7 Psmd3 Psmd6 SYNTHESIS OF PC%REACTOME DATABASE ID RELEASE 66%10145452 Synthesis of PC Chat Stard10 Ache Slc44a4 Cept1 Slc44a5 Slc44a3 Csnk2a2 Pctp Csnk2a1 Stard7 Chka Mfsd2a Csnk2b Phospho1 Lpcat1 Slc44a2 Pcyt1b Pcyt1a Lpin2 Pemt Lpin3 Abhd3 Lpin1 Bche HYALURONAN UPTAKE AND DEGRADATION%REACTOME%R-RNO-2160916.1 Hyaluronan uptake and degradation Cd44 Slc9a1 Stab2 Lyve1 Hexb Hexa Gusb Hyal1 Hyal2 Chp1 SIGNALING BY NOTCH1%REACTOME DATABASE ID RELEASE 66%10145913 Signaling by NOTCH1 Notch1 Dtx2 Dtx4 Maml1 Rbpj Crebbp Kat2a Snw1 Rbpjl2 Dtx1 PASSIVE TRANSPORT BY AQUAPORINS%REACTOME DATABASE ID RELEASE 66%10145707 Passive transport by Aquaporins Aqp7 Aqp11 Aqp4 Mip Aqp12a Aqp1 NCAM1 INTERACTIONS%REACTOME DATABASE ID RELEASE 66%10145505 NCAM1 interactions Col4a2 Col9a1 Col9a2 Col9a3 Col4a1 Ncam1 LOC501189 St8sia4 SIALIC ACID METABOLISM%REACTOME DATABASE ID RELEASE 66%10145633 Sialic acid metabolism St8sia1 Neu4 Neu2 St8sia3 Neu3 Neu1 St3gal5 Ctsa Nans Slc35a1 St8sia5 Slc17a5 St6galnac1 St6galnac2 Npl LOC501189 Cmas St8sia4 Nanp St6gal1 St6gal2 Glb1 St3gal2 St6galnac4 St3gal3 St6galnac3 Gne St3gal1 St6galnac6 St3gal4 St3gal6 G1 S DNA DAMAGE CHECKPOINTS%REACTOME DATABASE ID RELEASE 66%10144740 G1 S DNA Damage Checkpoints Psmc6 Psmb10 Mdm2 Psmb8 Psmb9 Psmb4 Psmb11 Psmb5 Psmf1 Psmb6 Psmd4 Psmb2 Psmd5 Psmd8 Psmd9 Psmb3 Psma8 Psmd11 Psmd12 Ccna2 Ccne2 Ccna1 Psmd13 Psmd14 Ccne1 Phf20 Atm Cdk2 Psmc3 Zfp385a Rfwd2 G6pc Psmb7 Psmb1 Psma5 Cdkn1a Cdkn1b LOC100910954 Mdm4 Chek2 Psma2 Psmc5 Psmd2 Psma1 Psma4 Psmc1 Cdc25a Psma3 Psmc4 Psmc2 Psma6 Psme1 Psmd1 Psme2 Psmd7 Psmd3 Psmd6 SODIUM-COUPLED PHOSPHATE COTRANSPORTERS%REACTOME DATABASE ID RELEASE 66%10145627 Sodium-coupled phosphate cotransporters Slc20a2 Slc34a1 Slc34a3 Slc20a1 REGULATION OF COMMISSURAL AXON PATHFINDING BY SLIT AND ROBO%REACTOME DATABASE ID RELEASE 66%10145632 Regulation of commissural axon pathfinding by SLIT and ROBO Robo2 Robo3 Robo1 REGULATION OF PTEN LOCALIZATION%REACTOME%R-RNO-8948747.1 Regulation of PTEN localization Pten Usp7 Pml Xiap PHASE II - CONJUGATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 66%10144773 Phase II - Conjugation of compounds Bpnt1 Slc35b2 Abhd14b Nat1 Glyatl3 Nat2 Acsm1 Sult6b1 Podxl2 Glyat Sult4a1 Slc35b3 Sult2a1 Nat3 Gstm7 Ggct Esd Gclm Gstm5 Gsto2 Gstk1 Cndp2 Gclc LOC100912430 Gstt2 Ggt7 Ggt6 Chac2 Chac1 Mgst3 Oplah LOC100910526 RGD1562392 Hpgds ste2 Impad1 Tpst1 Tpst2 Sult2b1 NEWGENE_1306455 LOC100910057 Comt Sult1b1 Mat1a LOC100910881 Sult1a1 Mat2b Sult1c2 Mgst1 LOC100363915 Ahcy N6amt1 Ugt2b Ugt1a8 Nnmt Mat2a Ugt2b37 Ugt1a9 As3mt Ugt1a6 Tpmt Gstp1 Ugt2b35 Mtrr Ugt2a1 Trmt112 Gsto1 Ugt2b15 Ugp2 Mtr Ugt1a1 Ugt2b17 RGD1559459 Ugt1a7c Papss2 Ugt1a5 Papss1 Ugt1a3 Ugt1a2 Ugdh Gstz1 Slc35d1 Gsta5 Gss Akr1a1 Gstm4 Slc26a2 Slc26a1 Cyp1a2 TRANSFERRIN ENDOCYTOSIS AND RECYCLING%REACTOME%R-RNO-917977.1 Transferrin endocytosis and recycling Atp6v1d Tcirg1 Atp6v0d1 Atp6v1c2 Tfrc Atp6v0d2 Tf Atp6v1a Atp6v0e2 Atp6v0e1 Atp6ap1 Atp6v1g3 Atp6v1e1 Atp6v1e2 Atp6v1c1 Atp6v1g1 Atp6v1g2 Atp6v0a4 Atp6v0a1 Atp6v1b2 Atp6v0a2 Atp6v1h Atp6v1f Tfr2 Hfe Steap2 Atp6v0c Mcoln1 NECTIN NECL TRANS HETERODIMERIZATION%REACTOME DATABASE ID RELEASE 66%10145613 Nectin Necl trans heterodimerization Pvrl3 PVR Pvrl4 Pvrl1 Pvrl2 Cadm3 REGULATION OF FZD BY UBIQUITINATION%REACTOME DATABASE ID RELEASE 66%10146037 Regulation of FZD by ubiquitination Lrp5 Lrp6 Wnt3 Rnf43 Fzd4 Fzd6 Rspo1 Lgr4 Lgr6 Lgr5 Rspo4 Wnt3a Usp8 Rspo2 Rspo3 FGFR3B LIGAND BINDING AND ACTIVATION%REACTOME%R-RNO-190371.1 FGFR3b ligand binding and activation Fgf1 Fgf17 Fgf9 Fgf8 Fgfr3 Fgf20 ION HOMEOSTASIS%REACTOME DATABASE ID RELEASE 66%10145041 Ion homeostasis Fxyd2 Camk2g Fxyd3 Fxyd4 Atp2b4 Stim1 Dmpk Atp2b2 Sri Atp2b1 Sln Tnni3 Camk2d Camk2a Clic2 Trdn Atp2a2 Fxyd6 Pln Fxyd7 Nos1 Atp2a3 Atp1b3 Atp1b2 Atp1b1 Fkbp1b Ryr2 Slc8a3 Prkaca Kcnj11 Itpr1 Ahcyl1 Itpr3 Atp1a4 Atp1a1 Slc8a2 Atp1a2 Slc8a1 Atp1a3 Abcc9 DEVELOPMENTAL BIOLOGY%REACTOME DATABASE ID RELEASE 66%10144967 Developmental Biology LOC102552659 Erbb2 Egfr Kif4a Cdk5 Dnm2 Actb Fyn Ephb1 Ephb2 Ephb4 Ephb3 Efnb2 Efnb1 Efnb3 Myl12a Nck2 Smad3 Smad2 Ranbp9 Akt1 Foxo1 Foxo3 Kdr Adam11 Stx1a Cacng8 Prkca Cacng2 Lyn Cacng3 Lgi4 Yes1 Cacng4 Lgi3 Rhob Stx1b Lgi1 Dlg4 Rhoc Adam23 Krt10 Tgm1 Krt13 LOC100910942 LOC690386 Dsg4 Grin2b Krt19 Klk8 Grin1 Krt18 Dsg3 Krt15 Dsg2 Krt14 Dsc3 Krt17 Ivl Mmp9 Krt16 Spink5 Dsc2 RGD1561281 Krt33b Spink6 Krt33a LOC684499 LOC100363184 LOC100910851 Rptn LOC680396 Mmp2 Krtap3-3 LOC100911681 Lipk Krtap3-1 Lipm Krtap4-5 Krt9 LOC100360690 LOC689230 Krt7 Krtap4-7 Stfa2l1 Rps6ka5 Krt2 Stfa2l3 Krt8 Stfa2l2 LOC100910814 LOC100912585 Krt4 Krtap4-13 LOC680160 Krtap11-1 LOC100363136 LOC100909618 LOC687631 Krtap12-2 LOC100365646 LOC689927 Krt75 Krtap8-1 Krt71 Ptprc Krtap24-1 Krt77 Col9a1 Krt73 Col9a2 Krt72 Col9a3 Prkcq Krtap1-1 Sdcbp Krt40 Cd72 Col4a1 Krt76 Siah1 Krtap1-3 Ret Krtap13-2 Krtap27-1 Siah2 Krtap1-5 Krtap14l Krt28 Dpysl2 LOC100361664 Dpysl5 Krt24 Dpysl4 Krt23 LOC100910964 Krt31 Fes Sh3gl2 Col4a2 Krt25 Nrcam Krt26 Gdnf Krt27 Reln Sh3kbp1 LOC690460 Rnd1 Krt35 Plxnd1 Krt34 Ntn1 Dag1 Krt32 Pdlim7 LOC690478 Ntn4 Krtap3-3l1 Map2k2 Krt39 Pspn Krt36 Dpysl3 Crmp1 Rras Ank1 Arhgef7 Plxna2 Plxna1 Rock1 Gap43 Sema7a Rdx LOC103692570 Rap1gap Sema6d Cdk5r1 Itsn1 Epha10 Dcc Farp2 Sema5a L1cam Ezr Kb23 Trem2 Krtap9-1 Spta1 Kalrn Gfra4 Sema4d Plxnb1 Gfra3 LOC100912512 Gfra2 Dok4 Krt81 Dok1 Krt80 Vav2 Dok6 Krtap26-1 Dok5 Krt82 Krt84 Arhgef11 Sema3a Krt83 Sema3e Efna2 Krt86 Dsp Efna1 Krt85 Artn Efna4 Shc3 Nrtn Ptpra Tiam1 Dnm1 Dab1 Vav3 Dnm3 RGD1565682 Epha4 Ncam1 Sptbn1 Epha5 Pkp1 Lypla2 Msn Ngef Epha7 Epha8 Pkp4 Epha3 Pkp3 Epha2 Sprr3 Klk12 Epha1 Klk13 Klk14 Stfa3l1 Casp14 Itga2b Stfa3 Evpl Csta LOC100911797 Ppl Perp Cela2a LOC100362978 Aph1b Psenen Aph1a LOC100911293 Psen2 Psen1 Ncstn Pik3r3 Mapk8 Vldlr Mapk7 Mapk1 Akt3 Creb1 Mapk14 Mapk11 Rxra Pparg Cdon Boc Cxcl12 Robo2 Robo3 Akap5 Enah Myo9b Vasp Abl2 Robo1 Cxcr4 Usp33 Slit3 Slit2 Plcg1 Potef Csnk2a2 Nck1 Csnk2a1 Rock2 Arpc1b LOC100909750 LOC100909840 Ptk2 Actg1 LOC100909609 Nrp1 Pik3cd Tln1 Vegfa Dock1 Gpc1 Rasa1 Shb Arhgef28 Pip5k1c Evl Limk1 Pak2 Pak3 Pak1 Wasl Abl1 Arpc4 Arpc3 LOC100361457 Actr3 Cdh2 Ctnna1 Mapk13 Mapk12 Dscaml1 Dscam Cdc42 Pfn1 Pfn2 Rac1 Arhgap35 Sdc2 Ap2a2 Src Hsp90ab1 Cltc Clta Ap2s1 LOC100912586 LOC100363287 Krtap15-1 Ap2a1 Ap2m1 Prkaca Prkacb Myf5 Myf6 Tcf4 Myog Sptan1 Gab1 Irs2 Foxh1 LOC103692716 Fgfr1 Grb10 Myod1 Mef2c Spag9 Frs2 Cdh15 Mef2a Akt2 Drap1 Kras Grb7 Dok2 Pik3r1 Pik3r2 Jup Nfasc Tyrobp Dsg1 Csnk2b Actr2 LOC501189 St8sia4 Pik3cb Ptpn11 Rhoa Arpc5 Hras Nras Sos1 Shc1 Grb2 GPCR DOWNSTREAM SIGNALLING%REACTOME DATABASE ID RELEASE 66%10144869 GPCR downstream signalling Plcb1 Plcb3 Ffar1 Gnaq Gna11 Gna14 Gna15 Plcb4 Gnai3 Akt1 Gnao1 Chrm4 Gnat2 Gnaz Rhob Rhoc Rps6ka2 Rps6ka1 App Rps6ka3 LOC100912585 Rock1 C5ar1 Tshb Gnal Gnat3 Grp Ppp2cb Ffar4 Ppp2ca Ppp2r1a Mapk7 Ppp2r1b Mapk1 Adora3 Creb1 Adora2a Adora2b LOC100911796 LOC100363178 Adora1 LOC100365814 Lrp1 Gpr39 Olr663 Olr660 Olr561 Olr1024 Olr560 LOC100910009 Olr158 Cnga1 Olr557 LOC100910335 Gucy2f Pde6b Olr164 Rcvrn Olr659 Olr160 Gucy2d Pde6a Olr657 Rgs9 Olr662 RGD1560341 Olr664 Olr1868 Olr1199 Gpr27 Olr653 LOC100910402 Olr651 Olr650 Olr294 LOC100911909 Olr544 Olr1197 Olr1196 Olr1195 Olr1194 Olr1198 LOC100910409 Olr1128 LOC100911893 LOC100910928 Olr323 Olr119 Olr1126 LOC100912097 Olr1125 Olr420 Olr217 Olr1121 Olr1122 Olr1129 Olr322 Olr214 Gpr84 Olr215 Olr414 Guca1b Ppef1 Olr1512 Kng1l1 Metap2 Olr1513 Metap1 Olr416 Olr556 Gnat1 Nmt1 Gpr150 Olr1511 Guca1a Cngb1 Olr413 Olr1517 Rgs9bp Olr319 Fnta Olr120 Nmt2 Olr321 Sag Olr1514 Grk4 LOC100911380 Grk1 Fntb Olr417 Olr418 Pde6g LOC100910041 Olr259 Olr1163 Olr1166 LOC684208 Olr127 Olr530 Olr126 Olr931 Olr674 Olr129 Olr532 Olr1174 Olr670 Gpr45 Olr675 Olr892 Olr247 Olr1156 Olr190 Olr194 Olr267 LOC500460 Olr192 Olr262 Olr1064 Olr896 Olr263 LOC100910049 Olr698 Olr799 LOC103693566 Olr922 Olr684 Olr1186 LOC100910120 Olr536 Olr1185 Olr143 Olr535 Olr140 Olr142 Olr148 LOC100910648 Olr1016 Olr149 Olr951 Gpr25 LOC100910224 Olr666 Olr1179 Olr522 Olr130 Olr527 Olr526 LOC100910637 Olr132 LOC100910010 Olr529 Olr528 Olr139 Olr137 Olr686 Olr1877 LOC100910559 Olr186 Olr189 Olr1081 Olr1147 Olr188 Olr584 Olr1082 Olr281 Olr382 Olr384 Olr1086 Olr1087 Olr587 Olr581 Olr282 Olr776 Olr582 Olr777 Olr583 Olr283 Olr962 Gpr15 Olr964 Olr285 Olr286 Olr1135 Olr1132 Olr172 LOC100910051 Olr1130 Olr170 Olr198 Olr588 Olr199 Olr1155 Olr597 Olr1057 Olr196 LOC100911805 Grk6 Olr252 Olr1052 Olr598 Olr695 Olr251 Olr250 Olr697 LOC100910999 Olr590 Grk5 LOC100910445 Olr1143 Olr180 Olr690 Olr1144 Olr783 Olr379 Olr1142 LOC100910162 Olr782 Gpr176 LOC100911839 Olr184 Olr845 LOC100910274 Olr847 Olr848 Olr1391 Gpihbp1 Olr852 Olr1496 LOC686792 LOC100912204 Olr1096 LOC100365798 RGD1562066 Olr844 Olr841 Olr744 Olr745 LOC100909686 Olr878 LOC100910597 Olr1376 Penk Olr850 Olr851 LOC100909578 LOC100909683 LOC100910294 Kng1 LOC687097 LOC100909884 LOC100909885 Olr1374 Olr1372 Olr1373 Olr1370 Kng2 Olr1071 Olr569 Olr174 Olr175 Olr774 Olr176 Htr4 Olr1274 Olr1076 LOC100910876 Olr575 Olr1075 Olr373 Olr1275 Olr1070 Olr1137 Htr7 Olr375 Olr377 Olr378 Olr372 Olr1079 Olr374 Olr1073 Olr854 Olr853 Olr279 LOC100911035 Olr765 Olr278 Olr376 Htr6 LOC100910256 Npff Npffr2 Olr834 Olr641 RGD1560028 LOC100909438 Psap Hcrt LOC100909796 Npffr1 Gpr83 Qrfp LOC690821 LOC100912217 LOC100909783 Olr601 Olr602 Olr604 Olr709 Olr609 Olr607 Olr608 LOC687088 Olfr873 Olr806 LOC686677 Olr702 Olr808 Olr705 Olr704 Olr807 Olr519 Oxgr1 Olr614 Olr718 Olr811 Ccr1 Olr514 Ccr1l1 Olr515 Ptgdr2 Olr611 Sucnr1 Olr610 Olr819 Olr716 Olr713 Olr816 Olr717 Olr714 Olr813 Olr812 Olr1382 Olr1381 Olr1384 Olr1383 Olr711 LOC100912327 Olr818 Olr712 Olr724 Olr1380 Reep6 LOC684683 Olr720 Olr722 LOC686660 Olr1385 Hcrtr1 Olr1378 Qrfpr Reep1 Cxcr2 Reep5 Hcrtr2 Olr729 Reep4 Reep3 Reep2 Olr725 Ptafr Gpr31 Cxcl2 Rgr Cxcl1 Gpr18 Gpr55 Gpsm3 Htr5a Gpsm2 Cxcl3 Gpsm1 Cnr2 Ccl4 Opn3 Cnr1 Htr1d Htr1f Htr1a Htr1b Hrh4 Ptger3 Gpr183 Mtnr1a Opn5 Pcp2 Hcar1 Hcar2 LOC687065 Drd5 Drd1 LOC684539 Drd4 Drd2 Olr820 Olr821 Olr823 Fpr1 Mgll Abhd12 Daglb Abhd6 Dagla C3ar1 Prkcd Kras Pik3r1 Pik3r2 Adra2a Gnai2 Adra2c Rbp4 C3 Lrp10 Rbp2 Ppbp Tex12 Rbp1 Lrp8 Apom Lrp12 Rhoa Lpl Bco1 Rdh11 Lrat Hras Nras Bco2 Sos1 Gnai1 Grb2 Olr1442 Olr1443 Olr1548 Olr80 Olr1440 Olr1547 Ppp1ca Pde4a Egfr Hbegf Pde4d Pde4c Ppp1r1b Ghrl Cdk5 Olr1436 Ptgir Olr1569 Olr1567 Olr1421 Olr1568 Olr1565 Olr1566 Olr1538 LOC100912374 Olr1539 Olr1437 Olr1439 Olr1433 Olr1434 Olr1435 LOC103690304 Olr83 LOC100912370 Olr1533 Olr1432 Olr1535 Olr1537 Olr1536 Olr81 Olr1449 Olr1542 Olr1541 Olr1540 Olr1445 LOC103693022 LOC100912463 Pnlip Clps Abca4 Prkca Oprl1 Tas2r144 Ccl21 Grm3 Casr Prokr2 Mc3r Grm1 Ccr5 Grm6 Gal Tas2r113 Ccr4 Grm2 Ccr3 Grm8 Gpr37 Ccl27 Cckar Tas2r114 Gper1 Tas2r110 Ccl20 Uts2r Prokr1 Ccl25 NMS Gprc6a Xcr1 Tas2r124 Cxcl16 Tas2r125 Pdyn Tas2r126 Tas2r121 Ccr10 Tas2r103 Gpr37l1 Tas2r104 Tas2r123 Ccl19 Ccr7 Tas2r116 Ccr8 Tas2r140 Cxcr3 Tas2r120 Tas2r102 Cxcl10 Ccr9 Tas2r145 Cxcl11 Tas2r119 Tas2r118 Tas2r117 Pde1b Sstr5 Brs3 Tas2r107 Tas2r108 Npbwr1 Tas2r105 Pyy Pnoc Tas2r106 Ccl5 Tas2r129 Npy2r Tas2r109 Mc4r Prkcq Tas2r136 Prok2 Tas2r137 Tas1r1 Oprm1 Prok1 Tas2r135 Mchr1 Sstr1 Tas2r13 Aplnr Tas2r130 Tas1r3 Sstr4 Tas2r139 Sstr2 Cck Npy1r Apln Tacr3 Apob Tacr2 Bdkrb1 Apoc2 Apoe Bdkrb2 Rln3 Apoa2 Npb Ppy Trh Ccl1 Npw Mc2r Npy Gng10 Nps Arhgef6 Arhgef5 Pde3a Arhgef39 Arhgef7 Arhgef37 Arhgef38 Arhgef33 Prex1 Adra1a Tbxa2r Itsn1 Arhgef2 LOC102556447 Arhgef4 Arhgef3 Plekhg5 Sstr3 Arhgef19 Arhgef18 Plekhg2 Kalrn Adra1d Plxnb1 LOC100912512 Gna12 Vav2 Gna13 Pde2a Vav1 Arhgef11 Cyct Akap13 Arhgef16 Pde10a Arhgef15 Pde11a Gphb5 Net1 Gnrhr Ect2 Gpha2 Arhgef26 Fgd2 Gnrh1 Mcf2l Tiam1 Fshr Tiam2 Vav3 Tshr Fgd3 Sos2 Ngef Cxcr5 Uts2b Npy5r Nmur2 Cxcr6 Oprd1 Trpc3 Trpc7 Lhcgr LOC100909513 Trpc6 LOC100360745 Olr1600 Olr1605 Olr1405 Olr1601 Olr1407 Olr1404 Olr1406 LOC100910837 Olr1368 Olr1369 Olr226 LOC100911348 Olr229 Olr227 Olr1602 LOC684170 LOC103692138 Olr1504 Lhb Olr233 Olr428 Olr232 Olr427 Olr1505 Olr234 LOC100911377 Olr1400 LOC100911376 Olr231 Ptgdr Olr425 Olr1501 Olr230 Olr208 Olr1202 Awat2 Adcy8 Olr244 LOC103693685 Adcy9 Olr1519 Adcy5 Olr203 Adcy4 Olr411 Adcy7 Olr209 Adcy6 Prkar1b Olr1007 Prkar1a Olr1006 LOC100911223 Ttr Olr237 Olr434 Olr1306 Olr442 Olr441 Olr113 Olr210 Olr1520 Olr114 Olr1523 Olr218 Olr1522 Olr1521 F2rl3 Olr206 F2r Olr1118 Olr204 F2 Olr205 RGD1564865 LOC100911398 Ptger2 Olr1115 Cga F2rl2 Olr1117 Hebp1 Uts2 Pde7a Pik3r5 Fpr-rs6 Ntsr2 Olr1734 Olr1340 Trhr Olr485 Nmu Fpr-rs3 Pf4 Olr486 Olr16 Mc5r Fpr2 Ntsr1 Olr1735 Fpr3 Pik3r3 LOC100911043 Pmch Anxa1 Pik3r6 Olr1737 Rxfp1 Olr14 Rxfp2 Olr1736 Fpr-rs4 Insl3 Olr488 Tac3 Olr484 Pde7b Kiss1 Olr1730 Rxfp3 LOC100912515 Tac1 Edn2 Olr1627 Olr491 Ednra Ednrb Olr1626 Edn3 Olr490 Grpr Olr1621 Cx3cr1 LOC100912408 Edn1 Olr1625 F2rl1 Olr1624 Olr200 Sst Olr339 Olr1345 Ackr3 Olr338 Nmb Olr1343 Xcl1 Cxcl9 Olr202 Olr1344 Cxcl6 Olr1341 Cx3cl1 Olr1356 Taar9 LOC100912605 LOC100911849 Hrh2 Fshb LOC100910199 Taar6 Agt Olr346 Taar5 Taar2 Olr1214 Olr450 Olr499 Olr496 LOC100912505 Olr493 Olr1606 Akt3 Olr1607 Olr1749 Agtr2 Olr1608 Olr1362 Galr1 Olr459 Nts Olr458 Olr1361 Oprk1 Olr1366 Olr1364 Olr360 Olr462 Olr1611 Olr1610 Olr1358 Olr1612 Olr20 Olr24 Olr23 Olr1456 LOC100912431 Olr1597 Olr1593 Olr1592 Olr1450 Olr1452 Olr1598 Olr1454 LOC100909966 LOC100365887 LOC100912159 Olr1654 LOC103693822 Olr30 Olr32 Pla2g4a Olr34 Olr331 Olr332 Olr1643 Olr334 Olr330 Olr1642 Olr1644 Olr1645 Olr473 Olr470 Olr1744 Olr1641 Olr1743 Olr1746 Olr472 Olr1640 Pde8b Olr477 Olr475 Pde8a LOC100911479 Olr1235 Olr1738 LOC103690286 Olr1231 Olr329 Or7e24 LOC103690280 Olr326 Olr325 Olr1339 Olr1639 Olr13 Olr12 Olr1637 Olr1638 Olr340 Olr341 LOC102555599 Olr1635 Gabbr1 Olr1630 Olr1631 Gabbr2 Olr1632 Olr1633 Olr1423 Olr1560 Olr63 LOC100912684 Olr1424 Olr1564 Olr1425 Olr1422 Olr1558 Olr1559 LOC684179 Olr1555 Ptgdrl Olr67 Olr68 Olr69 Olr1416 Cxcl12 Olr70 Olr1418 Olr1417 Olr1551 Adcy3 Prkar2b Olr1557 Prkar2a Olr1553 LOC686967 Olr77 LOC100909611 Olr1693 Rtp4 Olr74 Cxcr4 RGD1562400 Olr78 Olr75 Olr1583 Olr1589 Olr1488 LOC100912420 Olr1582 LOC100909993 Rtp3 Rtp2 Olr1475 Olr1470 LOC687110 Olr1576 Olr49 Olr46 Olr1588 Olr48 Arrb1 Olr1467 Olr1468 Olr1469 Olr50 Arrb2 Olr51 Olr59 Olr1671 Olr1471 Olr1667 Olr29 LOC100909831 Adrbk1 Olr27 Olr25 Cyp4v3 Olr1462 LOC100912540 LOC100911586 Rock2 Stra6 Rdh10 Rdh16 LOC100365958 LOC100362350 Akr1c12l1 Akr1c19 Akr1c13 Akr1c14 Akr1c12 Ccr6 Pomc Apoa1 Oxtr Oxt Rpe65 LOC100909648 Avpr1b Dhrs9 Pik3cg Avpr1a Myo7a Sdr9c7 Hsd17b6 Gpc6 Gpc4 Gpc2 Gpc1 Opn1sw Dhrs3 Rlbp1 Akr1b7 Akr1b8 Opn1mw Ghrh Ramp3 Vipr2 Sct Gip Gipr Akr1c2 Pth1r Iapp Crhr2 Akr1c3 Gcgr Crhr1 Glp2r Pth2 Ramp2 Ghrhr Akr1c1 Agrn Pdpk1 Sdc2 Sdc3 Sdc4 Adra2b Adrb3 Pth Sctr Adm Calcb Vip Calca Ramp1 Htr2c Htr2a Adcyap1r1 Dgkk Adcyap1 Dgki Pth2r Adm2 Htr2b Crh Lpar5 S1pr1 S1pr5 S1pr4 S1pr3 Lpar1 Lpar3 Lpar2 S1pr2 Ccl9 Ccl6 Dgkg Gpr4 Dgkd Dgke Dgka Dgkb Gpr132 Gnb3 Gpr143 Gnb5 Rgs3 Gnb2 Opn4 Rgs19 Gnb1 Rgs2 Gng13 Rgs18 Gng12 Hrh1 Gng11 Prkaca Chrm1 Prkacb Chrm5 Ghsr Itpr1 Arhgef25 Dgkz LOC100909523 Itpr3 LOC100912034 Dgkq Gnb4 Dgkh Cysltr2 Glp1r Camk4 Gcg Cysltr1 Gng4 Gpr65 Gngt2 Gpr68 Ptgfr Gng5 Gngt1 Prkch Ptger1 Gng8 Gng3 Chrm3 Agtr1b Agtr1a Chrm2 Ltb4r Ffar2 Ffar3 Ltb4r2 Avp Pde3b Akt2 P2ry6 Lpar6 P2ry4 P2ry1 Gpr17 Lpar4 P2ry12 P2ry2 P2ry10 P2ry13 Cckbr Gast Adrb2 Tacr1 PHOSPHATE BOND HYDROLYSIS BY NTPDASE PROTEINS%REACTOME DATABASE ID RELEASE 66%10146210 Phosphate bond hydrolysis by NTPDase proteins Entpd7 Entpd5 Entpd8 Entpd2 Entpd6 Entpd3 Entpd4 Entpd1 ANTAGONISM OF ACTIVIN BY FOLLISTATIN%REACTOME%R-RNO-2473224.1 Antagonism of Activin by Follistatin Fstl3 Fst Inhba PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR%REACTOME%R-RNO-392851.1 Prostacyclin signalling through prostacyclin receptor Ptgir Gnb3 Gnb5 Gnb2 Gnb1 Gng13 Gng12 Gng11 LOC100912034 Gnb4 Gng4 Gngt2 Gng5 Gngt1 Gng10 Gng8 Gng3 CHOLINE CATABOLISM%REACTOME%R-RNO-6798163.1 Choline catabolism Aldh7a1 Sardh Dmgdh Chdh MULTIFUNCTIONAL ANION EXCHANGERS%REACTOME DATABASE ID RELEASE 66%10145626 Multifunctional anion exchangers Slc26a2 Slc26a1 Slc26a7 Slc26a9 Slc26a6 Slc26a3 TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 66%10144823 tRNA Aminoacylation Sar1a Ppa2 OLFACTORY SIGNALING PATHWAY%REACTOME%R-RNO-381753.1 Olfactory Signaling Pathway Olr1442 Olr1443 Olr1548 Olr80 Olr1440 Olr1547 Olr1436 Olr1569 Olr1567 Olr1421 Olr1568 Olr1565 Olr1566 Olr1538 LOC100912374 Olr1539 Olr1437 Olr1439 Olr1433 Olr1434 Olr1435 LOC103690304 Olr83 LOC100912370 Olr1533 Olr1432 Olr1535 Olr1537 Olr1536 Olr81 Olr1449 Olr1542 Olr1541 Olr1540 Olr1445 LOC103693022 LOC100912463 Olr1600 Olr1605 Olr1405 Olr1601 Olr1407 Olr1404 Olr1406 LOC100910837 Olr1368 Olr1369 Olr226 LOC100911348 Olr229 Olr227 Olr1602 LOC684170 LOC103692138 Olr1504 Olr233 Olr428 Olr232 Olr427 Olr1505 Olr234 LOC100911377 Olr1400 LOC100911376 Olr231 Olr425 Olr1501 Olr230 Olr208 Olr1202 Olr244 LOC103693685 Olr1519 Olr203 Olr411 Olr209 Olr1007 Olr1006 LOC100911223 Olr237 Olr434 Olr1306 Olr442 Olr441 Olr113 Olr210 Olr1520 Olr114 Olr1523 Olr218 Olr1522 Olr1521 Olr206 Olr1118 Olr204 Olr205 LOC100911398 Olr1115 Olr1117 Olr1734 Olr1340 Olr485 Olr486 Olr16 Olr1735 LOC100911043 Olr1737 Gnal Olr14 Olr1736 Olr488 Olr484 Olr1730 LOC100912515 Olr1627 Olr491 Olr1626 Olr490 Olr1621 LOC100912408 Olr1625 Olr1624 Olr200 Olr339 Olr1345 Olr338 Olr1343 Olr202 Olr1344 Olr1341 Olr1356 LOC100912605 LOC100911849 LOC100910199 Olr346 Olr1214 Olr450 Olr499 Olr496 LOC100912505 Olr493 Olr1606 Olr1607 Olr1749 Olr1608 Olr1362 Olr459 Olr458 Olr1361 Olr1366 Olr1364 Olr360 Olr462 Olr1611 Olr1610 Olr1358 Olr1612 Olr20 Olr24 Olr23 Olr1456 LOC100912431 Olr1597 Olr1593 Olr1592 Olr1450 Olr1452 Olr1598 Olr1454 LOC100909966 LOC100365887 LOC100912159 Olr1654 LOC103693822 Olr30 Olr32 Olr34 Olr331 Olr332 Olr1643 Olr334 Olr330 Olr1642 Olr1644 Olr1645 Olr473 Olr470 Olr1744 Olr1641 Olr1743 Olr1746 Olr472 Olr1640 Olr477 Olr475 LOC100911479 Olr1235 Olr1738 LOC103690286 Olr1231 Olr329 Or7e24 LOC103690280 Olr326 Olr325 Olr1339 Olr1639 Olr13 Olr12 Olr1637 Olr1638 Olr340 Olr341 LOC102555599 Olr1635 Olr1630 Olr1631 Olr1632 Olr1633 Olr1423 Olr1560 Olr63 LOC100912684 Olr1424 Olr1564 Olr1425 Olr1422 Olr1558 Olr1559 LOC684179 Olr1555 Olr67 Olr68 Olr69 Olr1416 Olr70 Olr1418 Olr1417 Olr1551 Olr1557 Olr1553 LOC686967 Olr77 LOC100909611 Olr1693 Rtp4 Olr74 RGD1562400 Olr78 Olr75 Olr1583 Olr1589 Olr1488 LOC100912420 Olr1582 LOC100909993 Rtp3 Rtp2 Olr1475 Olr1470 LOC687110 Olr1576 Olr49 Olr46 Olr1588 Olr48 Olr1467 Olr1468 Olr1469 Olr50 Olr51 Olr59 Olr1671 Olr1471 Olr1667 Olr29 LOC100909831 Olr27 Olr25 Olr1462 LOC100912540 LOC100911586 Olr663 Olr660 Olr561 Olr1024 Olr560 LOC100910009 Olr158 Olr557 LOC100910335 Olr164 Olr659 Olr160 Olr657 Olr662 Olr664 Olr1868 Olr1199 Olr653 LOC100910402 Olr651 Olr650 Olr294 LOC100911909 Olr544 Olr1197 Olr1196 Olr1195 Olr1194 Olr1198 LOC100910409 Olr1128 LOC100911893 LOC100910928 Olr323 Olr119 Olr1126 LOC100912097 Olr1125 Olr420 Olr217 Olr1121 Olr1122 Olr1129 Olr322 Olr214 Olr215 Olr414 Olr1512 Olr1513 Olr416 Olr556 Olr1511 Olr413 Olr1517 Olr319 Olr120 Olr321 Olr1514 LOC100911380 Olr417 Olr418 LOC100910041 Olr259 Olr1163 Olr1166 LOC684208 Olr127 Olr530 Olr126 Olr931 Olr674 Olr129 Olr532 Olr1174 Olr670 Olr675 Olr892 Olr247 Olr1156 Olr190 Olr194 Olr267 LOC500460 Olr192 Olr262 Olr1064 Olr896 Olr263 LOC100910049 Olr698 Olr799 LOC103693566 Olr922 Olr684 Olr1186 LOC100910120 Olr536 Olr1185 Olr143 Olr535 Olr140 Olr142 Olr148 LOC100910648 Olr1016 Olr149 Olr951 LOC100910224 Olr666 Olr1179 Olr522 Olr130 Olr527 Olr526 LOC100910637 Olr132 LOC100910010 Olr529 Olr528 Olr139 Olr137 Olr686 Olr1877 LOC100910559 Olr186 Olr189 Olr1081 Olr1147 Olr188 Olr584 Olr1082 Olr281 Olr382 Olr384 Olr1086 Olr1087 Olr587 Olr581 Olr282 Olr776 Olr582 Olr777 Olr583 Olr283 Olr962 Olr964 Olr285 Olr286 Olr1135 Olr1132 Olr172 LOC100910051 Olr1130 Olr170 Olr198 Olr588 Olr199 Olr1155 Olr597 Olr1057 Olr196 LOC100911805 Olr252 Olr1052 Olr598 Olr695 Olr251 Olr250 Olr697 LOC100910999 Olr590 LOC100910445 Olr1143 Olr180 Olr690 Olr1144 Olr783 Olr379 Olr1142 LOC100910162 Olr782 LOC100911839 Olr184 Olr845 LOC100910274 Olr847 Olr848 Olr1391 Olr852 Olr1496 LOC686792 LOC100912204 Olr1096 LOC100365798 RGD1562066 Olr844 Olr841 Olr744 Olr745 LOC100909686 Olr878 LOC100910597 Olr1376 Olr850 Olr851 LOC100909578 LOC100909683 LOC100910294 LOC687097 LOC100909884 LOC100909885 Olr1374 Olr1372 Olr1373 Olr1370 Olr1071 Olr569 Olr174 Olr175 Olr774 Olr176 Olr1274 Olr1076 LOC100910876 Olr575 Olr1075 Olr373 Olr1275 Olr1070 Olr1137 Olr375 Olr377 Olr378 Olr372 Olr1079 Olr374 Olr1073 Olr854 Olr853 Olr279 LOC100911035 Olr765 Olr278 Olr376 LOC100910256 Olr834 Olr641 LOC100909438 LOC100909796 LOC690821 LOC100912217 Olr601 Olr602 Olr604 Olr709 Olr609 Olr607 Olr608 LOC687088 Olfr873 Olr806 LOC686677 Olr702 Olr808 Olr705 Olr704 Olr807 Olr519 Olr614 Olr718 Olr811 Olr514 Olr515 Olr611 Olr610 Olr819 Olr716 Olr713 Olr816 Olr717 Olr714 Olr813 Olr812 Olr1382 Olr1381 Olr1384 Olr1383 Olr711 LOC100912327 Olr818 Olr712 Olr724 Olr1380 Reep6 LOC684683 Olr720 Olr722 LOC686660 Olr1385 Olr1378 Reep1 Reep5 Olr729 Reep4 Reep3 Reep2 Olr725 Gnb1 LOC687065 LOC684539 Olr820 Gngt1 Olr821 Olr823 VLDLR INTERNALISATION AND DEGRADATION%REACTOME%R-RNO-8866427.1 VLDLR internalisation and degradation Ap2a2 Pcsk9 Clta Nr1h3 Nr1h2 Vldlr Ap2s1 Mylip Ap2a1 Ap2m1 Cltc BETA OXIDATION OF HEXANOYL-COA TO BUTANOYL-COA%REACTOME%R-RNO-77350.1 Beta oxidation of hexanoyl-CoA to butanoyl-CoA LOC100911186 Echs1 Hadh Acads Hadha Hadhb FANCONI ANEMIA PATHWAY%REACTOME%R-RNO-6783310.1 Fanconi Anemia Pathway Eme2 Wdr48 Eme1 Rpa1 Rpa2 Ercc1 Atrip Rpa3 RGD1564719 RGD1306926 Fance Fanca Fancf Ube2t Fancc Fancb Fancl Fanci Atr Usp1 Slx4 Poln Mus81 Dclre1a Slx1b Fan1 REGULATION OF TP53 ACTIVITY THROUGH ASSOCIATION WITH CO-FACTORS%REACTOME%R-RNO-6804759.1 Regulation of TP53 Activity through Association with Co-factors Tp63 Tp53bp2 Pou4f2 LOC100910954 Banp Akt1 Akt3 Zfp385a Ppp1r13b Ppp1r13l Tp73 Phf20 Akt2 CLEC7A (DECTIN-1) INDUCES NFAT ACTIVATION%REACTOME%R-RNO-5607763.1 CLEC7A (Dectin-1) induces NFAT activation RGD1560225 Ppp3ca Nfatc2 Ppp3r1 Nfatc3 GP1B-IX-V ACTIVATION SIGNALLING%REACTOME DATABASE ID RELEASE 66%10145640 GP1b-IX-V activation signalling Flna Gp1ba Src Gp9 Gp5 Gp1bb LOC100911551 Pik3r1 Raf1 Vwf Ywhaz CATION-COUPLED CHLORIDE COTRANSPORTERS%REACTOME DATABASE ID RELEASE 66%10145620 Cation-coupled Chloride cotransporters Slc12a4 Slc12a2 Slc12a1 Slc12a6 Slc12a7 Slc12a5 FGFRL1 MODULATION OF FGFR1 SIGNALING%REACTOME%R-RNO-5658623.1 FGFRL1 modulation of FGFR1 signaling Fgf23 Fgf22 Fgf4 Spred1 Spred2 Fgf3 Fgf17 Fgfrl1 Fgf10 Fgf5 Fgf2 Fgf8 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS%REACTOME%R-RNO-111465.1 Apoptotic cleavage of cellular proteins Prkcd Bmx Rock1 Apc Dsg3 Birc2 Dsg2 Sptan1 Lmna Casp3 Mapt Casp6 Stk26 Stk24 Add1 Acin1 Gas2 Ocln Tjp2 Bcap31 Dsp Cdh1 Casp8 Dsg1 Clspn Prkcq Plec Gsn Lmnb1 Pkp1 Vim Dbnl Fnta Ptk2 Satb1 MICRORNA (MIRNA) BIOGENESIS%REACTOME%R-RNO-203927.1 MicroRNA (miRNA) biogenesis Prkra Ago3 Dicer1 Ago4 Ago2 Tarbp2 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES%REACTOME%R-RNO-1834941.1 STING mediated induction of host immune responses Nlrp4 Dtx4 Tbk1 Ddx41 Nlrp4a Irf3 Stat6 Tmem173 MEIOTIC RECOMBINATION%REACTOME%R-RNO-912446.1 Meiotic recombination Prdm9 RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF KERATINOCYTES%REACTOME DATABASE ID RELEASE 66%10146265 RUNX1 regulates transcription of genes involved in differentiation of keratinocytes MGC114246 Cts8l1 LOC100364523 Testin RGD1308751 Ctsl Cts8 Cts7 Ctsm Ctsj RGD1564657 RGD1564827 Ctsk Ctsq Serpinb13 Ctsr MITOCHONDRIAL PROTEIN IMPORT%REACTOME DATABASE ID RELEASE 66%10146287 Mitochondrial protein import Pitrm1 Hscb Ldhd Otc Atp5b Ndufb8 Coq2 ENZYMATIC DEGRADATION OF DOPAMINE BY MONOAMINE OXIDASE%REACTOME DATABASE ID RELEASE 66%10145518 Enzymatic degradation of Dopamine by monoamine oxidase Maoa Comt G ALPHA (Z) SIGNALLING EVENTS%REACTOME%R-RNO-418597.1 G alpha (z) signalling events Adcy3 Gnaz Adcy8 Adcy9 Adcy5 Adra2a Adcy4 Adcy7 Adcy6 Adra2c Gnb3 Adra2b Gnb5 Gnb2 Gnb1 Gng13 Gng12 Gng11 LOC100912034 Gnb4 Gng4 Gngt2 Gng5 Gngt1 Gng10 Gng8 Gng3 SURFACTANT METABOLISM%REACTOME DATABASE ID RELEASE 66%10145605 Surfactant metabolism Adgrf5 Napsa Sftpa1 Csf2ra Csf2rb Adra2a Lmcd1 Adra2c Abca3 Slc34a1 Ccdc59 Adora2a Zdhhc2 Adora2b Sftpb Ckap4 Ttf1 P2ry2 AUTODEGRADATION OF CDH1 BY CDH1:APC C%REACTOME DATABASE ID RELEASE 66%10145213 Autodegradation of Cdh1 by Cdh1:APC C Psmc6 Psmb10 Psmb8 Psmb9 Psmb4 Psmb5 Psmf1 Psmb6 Psmd4 Psmb2 Psmd5 Psmd8 Psmd9 Psmb3 Psmd11 Psmd12 Anapc11 Anapc15 Psmd13 Anapc10 Psmd14 Fzr1 Psmc3 G6pc Ube2d1 Psmb7 Psmb1 Anapc7 Cdc26 Cdc27 Psma5 Cdc23 Ube2c Anapc16 Cdc16 Anapc4 Psma2 Anapc2 Anapc1 Psmc5 Psmd2 Psma1 Psma4 Psmc1 Psma3 Psmc4 Psmc2 Psma6 Psme1 Psmd1 Psme2 Psmd7 Psmd3 Psmd6 GLYCOPROTEIN HORMONES%REACTOME DATABASE ID RELEASE 66%10145514 Glycoprotein hormones Lhb Fshb Inha Inhbc Tshb Cga Inhba RRNA PROCESSING IN THE NUCLEUS AND CYTOSOL%REACTOME DATABASE ID RELEASE 66%10146162 rRNA processing in the nucleus and cytosol Rps20 Rps27l LOC100360573 Rps4x LOC100359951 LOC100359593 LOC100359503 LOC100362640 Rps3 Rps15a Rps2 Rps13 Rps12 LOC100911372 LOC100361854 LOC684988 LOC103689992 Rps5 Rps7 Rps6 LOC100362830 LOC100363012 LOC100362149 Exosc3 Exosc9 LOC100359574 Exosc2 Exosc1 Exosc4 Exosc7 Exosc5 Dcaf13 Tbl3 Tsr1 Emg1 Wdr75 Wdr18 Wdr43 Wdr46 Nhp2l1 C1d Nob1 Fcf1 Wdr12 Senp3 Wdr36 Ebna1bp2 Rpp25 Riok3 Riok1 Utp14a Bysl NEWGENE_1564769 Rpp21 Pdcd11 Rpp40 Skiv2l2 Heatr1 Riok2 Rpp38 Rrp36 Rpp30 Bop1 Utp20 Dhx37 Utp18 Gnl3 Utp15 Utp11l Pno1 Pwp2 Wbscr22 Mphosph6 Imp4 Imp3 Nop56 Tex10 Utp6 Rcl1 Nol6 Utp3 Ncl Nop14 Xrn2 Rrp9 Rrp7a Pes1 Exosc10 Krr1 Nol9 Mphosph10 LOC100910568 Rpp14 Cirh1a Diexf Nop58 Ddx52 Rps16 Ltv1 Wdr3 Noc4l Ddx49 Ddx47 Las1l Fbl Rps18 LOC100360679 Rps15 Ddx21 Rps3a Csnk1d Csnk1e INITIATION OF NUCLEAR ENVELOPE REFORMATION%REACTOME DATABASE ID RELEASE 66%10145989 Initiation of Nuclear Envelope Reformation Vrk2 Vrk1 METABOLISM OF STEROIDS%REACTOME DATABASE ID RELEASE 66%10145088 Metabolism of steroids Nr1h4 Ppapdc2 Mbtps1 Mbtps2 Sc5d Hsd17b3 Lhb Acot8 Hsd17b1 Nsdhl Hsd17b2 Osbpl3 Hsd17b4 Osbpl6 Osbpl9 Stard6 Osbpl7 Cyp19a1 Stard3 Fdx1l RGD1562948 Gc Msmo1 Stard4 Stard5 Acat2 Akr1c12l1 LOC100911154 Baat Cyp46a1 Mvd Akr1c19 Hsd3b Akr1c13 Akr1c14 RGD1564865 Akr1c12 Cga Amacr Akr1d1 Cyp39a1 Pomc Vdr Scap Cyp51 Fdx1 Cubn Slc21a4 Hsd3b1 Bzrap1 Hsd3b2 Abcb11 Hsd3b7 Stard3nl Acox2 Ch25h Srd5a3 RGD1564347 Slc27a2 Tspo Cyp24a1 Srd5a1 Srd5a2 Pmvk Srebf1 Dhcr24 Srebf2 Slco1a1 Kpnb1 Arv1 Sqle Ptgis Slco1a4 Slco1a2 Lgmn RGD1306195 Rxra Slco1b2 Akr1b7 Akr1b8 Fabp6 Star Cyp7b1 Fdft1 Hmgcs1 Akr1c2 Akr1c3 Cyp7a1 Tm7sf2 Cyp21a1 Fdxr Cyp2r1 Ncoa1 Akr1c1 Osbp Ggps1 Slc27a5 Cyp11b2 Cyp27b1 Slco1a6 Ncoa2 Dhcr7 Akr1b1 Cyp8b1 Hsd17b14 Slc10a1 Hmgcr Ebp Hsd11b2 Slc10a2 Hsd17b12 Hsd17b11 REGULATION OF GENE EXPRESSION IN BETA CELLS%REACTOME%R-RNO-210745.1 Regulation of gene expression in beta cells Akt3 Foxo1 Akt1 Akt2 ACTIVATION OF BH3-ONLY PROTEINS%REACTOME DATABASE ID RELEASE 66%10145046 Activation of BH3-only proteins Mapk8 Dynll2 Ywhah Bcl2l11 Ywhag Sfn Ywhaz Ppp3r1 Bcl2 Bid Ywhab Ywhaq Ywhae Bmf Pmaip1 Bad EXPRESSION AND PROCESSING OF NEUROTROPHINS%REACTOME%R-RNO-9036866.1 Expression and Processing of Neurotrophins Ngf Pcsk6 Pcsk5 Furin G2 PHASE%REACTOME DATABASE ID RELEASE 66%10145274 G2 Phase Cdk2 E2f1 E2f3 Ccna2 Ccna1 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION%REACTOME%R-RNO-109688.1 Cleavage of Growing Transcript in the Termination Region Rnps1 Thoc5 Thoc7 Thoc3 Snrpf Thoc2 Thoc1 Wdr33 Magohb Rbm8a Pcf11 Fip1l1 Thoc6 Nudt21 Zfp473 Snrpd3 Ddx39a Cstf2 Ddx39b Chtop U2af1l4 Cpsf7 Cpsf2 Cpsf3 Cpsf4 Cstf1 Cpsf1 Sarnp Slu7 Srsf3 Upf3b U2af2 Papola Srsf6 Srsf7 Srsf4 Lsm10 Lsm11 Srsf5 Srsf2 LOC679894 Srsf9 Dhx38 Clp1 Magoh Ncbp2 Srsf1 Poldip3 Ncbp1 Cstf2t Eif4a3 Fyttd1 Sympk Slbp LOC100910660 Srrm1 Cdc40 LOC361990 Snrpb CA2+ PATHWAY%REACTOME DATABASE ID RELEASE 66%10145578 Ca2+ pathway Plcb1 Pde6b Nlk Plcb3 Wnt5a Pde6a Camk2a Fzd3 Fzd2 Gnao1 Fzd4 Fzd6 Ppp3r1 Wnt11 Gnat2 Map3k7 Gnb3 Gnb5 Gnb2 Gnb1 Gng13 Gng12 Gng11 RGD1560225 Ppp3ca LOC100910771 LOC100912034 Gnb4 Lef1 Gng4 Gngt2 Gng5 Gngt1 Gng10 Gng8 Pde6g Gng3 VITAMIN E%REACTOME DATABASE ID RELEASE 66%10146249 Vitamin E Ttpa INTRACELLULAR SIGNALING BY SECOND MESSENGERS%REACTOME DATABASE ID RELEASE 66%10144994 Intracellular signaling by second messengers Ereg Nrg1 Trim27 Btc Usp7 LOC102552659 Mdm2 Erbb3 Erbb2 Nrg3 Egfr Hbegf Esr2 Nrg4 Csnk2a2 Nr4a1 Csnk2a1 Pml Fyn Il1rap Nrg2 Pik3ap1 Il1rl1 Akt1 Hdac1 Phlpp1 Ier3 Pdgfa Rps6kb2 Pdgfb Foxo1 Foxo3 Pik3cd Stub1 Irak4 Cdkn1a Cdkn1b Prkca Traf6 Il33 Pip5k1c Pde1b Pip5k1b Pip5k1a Cd19 LOC100909468 Hgf Rac2 Ppp2r5e G6pc Pdgfra Pdgfrb Frk Psmb7 Psmb1 Ppp2r5c Ppp2r5a Ppp2r5b Vav1 Foxo4 Psma5 Pdpk1 Psma2 Psmd2 Psmc2 Psmd1 Psmd7 Kit Kitlg Psmd3 Psmd6 Psmc6 Pten Psmb10 Psmb8 Psmb9 Psmb4 Psmb11 Psmb5 Psmf1 Psmb6 Rac1 Psmd4 Psmb2 Psmd5 Psmd8 Psmd9 Psmb3 Psma8 Psmd11 Psmd12 Psmd13 Psmd14 RragB Rictor Adcy8 Adcy9 Adcy5 Adcy4 Adcy7 Adcy6 Prkar1b Prkar1a Fgf2 Psmc3 Pip4k2b Pip4k2c Src Pik3r3 Akt1s1 Ppp2cb Ppp2ca Ppp2r1a Xiap Tnks Phc1 Phc2 Mtor Rheb Rptor Lamtor4 Chuk Lamtor5 Ppp2r1b Mlst8 Tsc2 Rraga Mapk1 Rragc Prkaca Prkacb Akt3 Rragd Slc38a9 Creb1 Camk4 Myd88 Cd80 Cd86 Otud3 Fgf23 Fgf22 Fgf4 Fgf1 Fgf3 Fgf6 Fgf5 Lamtor3 Fgf20 Gab1 Sall4 Scmh1 Cbx4 Cbx2 Cbx8 Fgf16 Lamtor2 Cbx6 Fgf17 Lamtor1 Bmi1 Irs2 Hdac2 Fgf10 Fgf9 Rnf2 Fgfr2 Mbd3 Fgf7 Usp13 Fgf8 Ring1 Chd3 Hdac1l Fgfr3 Chd4 Trib3 Phc3 Fgfr1 Prex2 Fgfr4 Esr1 Insr Ins1 Ins2 Mta3 Fgf19 Erbb4 Tnks2 Them4 Irs1 Mta1 Frs2 Mta2 Gatad2a LOC100910717 Maf1 Gatad2b Akt2 Prkcd Eed Pik3r1 Pik3r2 Rbbp7 Mecom Cd28 Icos Adcy3 Prkar2b Prkar2a Casp9 Csnk2b Mapkap1 Psmc5 Pik3cb Psma1 Psma4 Psmc1 Ptpn11 Psma3 Psmc4 Psma6 Psme1 Ezh2 Psme2 Adrbk1 Rhog Grb2 RECEPTOR MEDIATED MITOPHAGY%REACTOME DATABASE ID RELEASE 66%10146273 Receptor Mediated Mitophagy Csnk2a2 Csnk2b Ulk1 Src Atg12 Map1lc3a Csnk2a1 Pgam5 Fundc1 SOS-MEDIATED SIGNALLING%REACTOME%R-RNO-112412.1 SOS-mediated signalling Irs2 Irs1 Sos1 Grb2 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT%REACTOME%R-RNO-201681.1 TCF dependent signaling in response to WNT Psmc6 Psmb10 Psmb8 Psmb9 Psmb4 Psmb11 Psmb5 Psmf1 Psmb6 Psmd4 Rbx1 Psmb2 Psmd5 Psmd8 Csnk2a2 Psmd9 Leo1 Psmb3 Psma8 Psmd11 Csnk2a1 Psmd12 Psmd13 Psmd14 LOC100361515 Psmc3 Lrp5 Lrp6 Wnt3 Rnf43 Rspo1 Lgr4 Lgr6 Lgr5 Rspo4 Sox9 Wnt3a Rspo2 Usp8 Rspo3 Rbbp5 Wnt5a Akt1 Fzd1 Hdac1 Fzd2 Fzd4 Fzd6 Ywhaz Wnt1 Xiap Tnks Btrc Apc Dkk1 Kremen2 Sost Chd8 Hist1h2bo Hist1h2bcl1 Hist2h3c2 Hist1h2bk Pip5k1b H3f3b Smarca4 Hdac1l Xpo1 Tle3 Tnks2 Crebbp LOC100910717 Akt2 Peg12 LOC100910200 Cdc73 H2afx Frat2 Hist1h4b LOC684841 G6pc Hist1h2bh LOC100912290 Hist1h2ail1 Hist1h4m LOC102549173 LOC103690002 Tert LOC100910152 Men1 Psmb7 LOC100912338 Hist1h3c Psmb1 H2afb3 Hist1h3f Hist2h4 LOC684819 Hist1h3a H2afj Hist2h2aa3 Hist1h2bq Hist2h2aa2 Ash2l LOC100364835 LOC684762 Sox2 Hecw1 Csnk2b Dact1 Wnt8a Psma5 Sox7 Sox6 Sry Sox17 Ctnnbip1 Dvl1 Ryk Wnt8b Dkk2 Dkk4 Cby1 Psma2 Sox13 Psmc5 Pygo2 Psmd2 Psma1 Dvl2 Psma4 Dvl3 Psmc1 Psma3 Csnk1e Psmc4 Psma6 Psmc2 Psme1 Hist1h2bg Tcf7 Psme2 Lef1 Psmd1 Psmd7 Tcf7l1 LOC680097 LOC684797 Bcl9l Tle4 LOC100912418 Tle1 Hist1h2ba Tle2 Psmd3 Hist3h2bb Psmd6 Pygo1 OTHER INTERLEUKIN SIGNALING%REACTOME%R-RNO-449836.1 Other interleukin signaling Csf1 Stxbp2 Csf1r Ptprz1 Txlna Stx1a Csf3r Casp3 Vamp2 Stx3 Stx4 Il16 Cd4 Csf3 INTRA-GOLGI TRAFFIC%REACTOME DATABASE ID RELEASE 66%10146194 Intra-Golgi traffic Cux1 Stx5 Napg Ric1 Napb Napa Rab36 Rgp1 Man1c1 Nsf Alppl2 Stx16 Man1a1 Golim4 Cog4 Golga5 Cog6 Cog8 Cog3 Man2a1 Alpp Cog1 Alpi Cog2 Man2a2 Cog7 Snap29 Stx6 Rab30 Rab39a Cyth1 Cyth4 Rab33b Cyth3 Man1a2 Cyth2 Trip11 Ykt6 Gosr2 Gosr1 Vps45 GRB2 EVENTS IN ERBB2 SIGNALING%REACTOME DATABASE ID RELEASE 66%10145849 GRB2 events in ERBB2 signaling Ereg Nrg1 Kras Btc LOC102552659 Erbb2 Nrg3 Hbegf Nrg4 Erbb4 Hras Nras Sos1 Nrg2 Grb2 DAP12 INTERACTIONS%REACTOME%R-RNO-2172127.1 DAP12 interactions Kras Pik3r1 Pik3r2 Klrc2 Rac1 Cd300lb Siglec15 Trem2 Cd300e LOC100360575 Sirpa Tyrobp Vav2 Trem1 Fyn Vav3 Clec5a B2m Pik3cb Lat Plcg1 Hras Nras Sos1 LOC100909879 Lcp2 Shc1 Syk Grb2 ORGANIC ANION TRANSPORT%REACTOME%R-RNO-561048.1 Organic anion transport Slc22a7 Slc22a6 TRYPTOPHAN CATABOLISM%REACTOME%R-RNO-71240.1 Tryptophan catabolism Aadat Kmo Kynu Ccbl1 Ido1 Slc7a5 Slc36a4 Tdo2 SYNTHESIS OF LIPOXINS (LX)%REACTOME DATABASE ID RELEASE 66%10145463 Synthesis of Lipoxins (LX) Hpgd Alox5ap Alox12 Ltc4s Alox5 AXONAL GROWTH STIMULATION%REACTOME%R-RNO-209563.1 Axonal growth stimulation Ngf Rhoa Arhgdia Ngfr SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL%REACTOME%R-RNO-1855183.1 Synthesis of IP2, IP, and Ins in the cytosol Inpp1 Inpp5a Isyna1 Inpp5b Synj1 Impa1 Inpp4a Ocrl Impa2 Inpp5j Inpp4b RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 66%10144903 RNA Polymerase II Transcription Initiation And Promoter Clearance Gtf2h1 Gtf2h2 Gtf2e1 Gtf2e2 Mnat1 RGD1565904 Taf11 Polr2g Ercc3 Taf2 Polr2h Taf15 Polr2e Polr2f Polr2j Taf13 Taf9 Polr2k Taf12 Polr2d LOC100911822 Taf7 Polr2i Taf4b Polr2b Polr2c Taf3 Ercc2 Taf6 Polr2a Taf5 Gtf2f1 LOC100912534 Gtf2f2 Gtf2a1 Cdk7 Atp5c1 Taf10 Taf7l Gtf2b Ccnh Gtf2h3 Gtf2h5 Tbp Gtf2h4 Taf9b SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21%REACTOME DATABASE ID RELEASE 66%10145271 SCF(Skp2)-mediated degradation of p27 p21 Psmc6 Psmb10 Psmb8 Psmb9 Psmb4 Psmb5 Psmf1 Psmb6 Psmd4 Cul1 Psmb2 Psmd5 Ptk6 Psmd8 Psmd9 Psmb3 Psmd11 Psmd12 Ccna2 Ccne2 Ccna1 Psmd13 Psmd14 Ccne1 Cdk2 Cks1l Psmc3 Cks1b G6pc Cdk4 Psmb7 Psmb1 Ccnd1 Skp1 Psma5 Skp2 Cdkn1a Cdkn1b Psma2 Psmc5 Psmd2 Psma1 Psma4 Psmc1 Psma3 Psmc4 Psmc2 Psma6 Psme1 Psmd1 Psme2 Psmd7 Psmd3 Psmd6 GLYOXYLATE METABOLISM AND GLYCINE DEGRADATION%REACTOME%R-RNO-389661.1 Glyoxylate metabolism and glycine degradation Ndufab1 Ogdh LOC683884 Gcsh LOC100911156 Pdhb LOC100365902 Pdha2 Pdha1 Pdhx Pdha1l1 Got2 Lipt2 Lipt1 Agxt2 Bckdhb Amt Grhpr Hao1 Hoga1 Gnmt Tas1r2 Ddo Dhtkd1 LOC100911564 Dlat Aldh4a1 Dbt Gldc Dlst Agxt Iffo2 Lias Dld ERYTHROPOIETIN ACTIVATES RAS%REACTOME DATABASE ID RELEASE 66%10146321 Erythropoietin activates RAS Irs2 Lyn Epor Crkl Vav1 Rapgef1 Shc1 Grb2 Epo LOC100911248 MITOCHONDRIAL UNCOUPLING PROTEINS%REACTOME DATABASE ID RELEASE 66%10145136 Mitochondrial Uncoupling Proteins Ucp2 Ucp3 LOC100909612 Slc25a14 Ucp1 INTERACTION BETWEEN L1 AND ANKYRINS%REACTOME DATABASE ID RELEASE 66%10145576 Interaction between L1 and Ankyrins L1cam Ank1 Spta1 Sptbn1 Sptan1 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX%REACTOME%R-RNO-204174.1 Regulation of pyruvate dehydrogenase (PDH) complex Gstz1 Pdp1 Pdpr Rxra Dlat Pdhb Pdk3 Pdk4 Pdk1 Pdk2 LOC100365902 Pdha2 Pdha1 Pdhx Ppard Pdha1l1 Dld ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S%REACTOME%R-RNO-72662.1 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S LOC100912571 Eif3l Eif2s3 Eif3m Eif3j Eif4ebp1 Eif3k Rps20 Rps27l Eif3e Eif3f Eif3b Eif3a Eif3d Eif3c LOC100360573 Eif2s1 Eif2s2 Eif4g1 Rps4x LOC100359951 LOC100359593 LOC100359503 LOC100362640 Rps3 Rps15a Rps2 Rps13 Rps12 Pabpc2 Pabpc6 LOC100911372 LOC100361854 LOC684988 LOC103689992 Rps5 Rps7 Rps6 Eif3g Eif3h Eif4a2 LOC100362830 Eif1ax Eif4a1 LOC100363012 LOC680559 LOC100911110 LOC100362149 Rps16 LOC100911431 Pabpc1 Rps18 LOC100360679 Rps15 Eif4h Eif4b Rps3a SYNTHESIS OF DOLICHYL-PHOSPHATE%REACTOME DATABASE ID RELEASE 66%10145306 Synthesis of Dolichyl-phosphate Dolk Mvd Nus1 Dolpp1 Srd5a3 Dhdds KETONE BODY CATABOLISM%REACTOME%R-RNO-77108.1 Ketone body catabolism Acat1 Oxct1 REDUCTION OF CYTOSOLIC CA++ LEVELS%REACTOME%R-RNO-418359.1 Reduction of cytosolic Ca++ levels Atp2b4 Atp2a2 Sri Atp2b2 Atp2b1 Slc8a2 Slc8a3 Slc8a1 Atp2a3 TCR SIGNALING%REACTOME DATABASE ID RELEASE 66%10145376 TCR signaling Psmc6 Pten Psmb10 Psmb8 Psmb9 Psmb4 Psmb11 Psmb5 Psmf1 Psmb6 Traf6 Psmd4 Psmb2 Cul1 Psmd5 Fyb Psmd8 Psmd9 Psmb3 Nck1 Psma8 Psmd11 Cdc34 Psmd12 Cd4 Psmd13 Rela Psmd14 Map3k7 Ptprc Prkcq Psmc3 Pak2 Nfkbia Pak3 LOC100910771 Ube2n Pak1 Bcl10 G6pc Pik3r1 Pik3r2 Ptpn22 Ube2d1 Ptprj Psmb7 Inpp5d Psmb1 Cd3e RT1-Ba RT1-Bb Skp1 RT1-Da RT1-Db2 RT1-Db1 LOC688090 Was Nfkb1 Cd247 Cd101 Psma5 Csk Fbxw11 Chuk Btrc Pdpk1 Psma2 Psmc5 Pik3cb Cd3g Psma1 Psmd2 LOC100362142 Psma4 Psmc1 Cd3d Psma3 Psmc4 Psma6 Psmc2 Lat Tab2 Psme1 Plcg1 LOC100912618 Ube2v1 Psme2 Psmd1 Ikbkb Psmd7 Lcp2 Psmd3 Itk Psmd6 SUMOYLATION%REACTOME%R-RNO-2990846.1 SUMOylation Nr1h4 Nup43 Nup133 Trim27 Mdm2 Vhl Pias3 Aaas Pias1 Npap60 Stag1 Nup35 Nup37 Pias4 Pml Rad21 Pias2 Smc1a Stag2 Smc3 Sumo1 Sumo3 Pcna Brca1 Blm Mdc1 Zfp131 Pcgf2 Xpc Ube2i Hdac4 Uhrf2 Ranbp2 Foxl2 Satb2 Satb1 Birc5 Topors Thra Thrb Nsmce1 Ing2 Nsmce2 Mbd1 Nr1h3 Nr1h2 Top1 Safb Park7 Smc6 Tp53bp1 Smc5 Nr5a1 Rora Senp5 Nr1i2 Rad52 Mitf Herc2 Hdac1 Xrcc4 LOC100911274 Nup88 Rpa1 Hipk2 Nup85 Phc1 Phc2 Nfkb2 Tfap2c Sin3a Rae1 Nup93 Nup98 Nup107 Rxra Nup210 Ppara Nupl2 Rela Nupl1 Tdg Cdca8 Scmh1 Nr5a2 Cbx4 Cbx2 Cbx8 Bmi1 Hdac2 Rnf2 Rangap1 Ikbke Ring1 Hdac1l Phc3 Aurkb Esr1 Nfkbia Nup205 Ddx5 Mta1 Nrip1 Pgr Ncoa1 Hist1h4b Incenp Dnmt1 LOC100912290 Nup155 Nop58 Hist1h4m LOC690251 Dnmt3b Hist2h4 Sae1 Uba2 Nup153 Rwdd3 Parp1 Tpr Daxx Mkl1 Senp2 Nup54 Senp1 Pom121 LOC680097 Nup62 LOC100912418 CALMODULIN INDUCED EVENTS%REACTOME DATABASE ID RELEASE 66%10144991 Calmodulin induced events Prkcd Pde1b Adcy8 Adcy9 Adcy5 Adcy4 Adcy7 Adcy6 Prkar1b Prkar1a Prkaca Prkacb Adcy3 Prkar2b Prkca Prkar2a Camk4 Adrbk1 ACTIVATION OF PKB%REACTOME DATABASE ID RELEASE 66%10144955 Activation of PKB Them4 Trib3 Pdpk1 Akt2 MET ACTIVATES PTK2 SIGNALING%REACTOME DATABASE ID RELEASE 66%10146246 MET activates PTK2 signaling Hgf Lama4 Src Lamc1 Lamc2 Lamb1 Itga3 Ptk2 Lama1 Lamb2 Lamb3 OPIOID SIGNALLING%REACTOME%R-RNO-111885.1 Opioid Signalling Plcb1 Ppp1ca Pde4a Plcb3 Pde4d Pde4c Ppp1r1b Cdk5 Pla2g4a Pdyn Pde1b Adcy8 Adcy9 Adcy5 Adcy4 Adcy7 Adcy6 Prkar1b Prkar1a Oprm1 Plcb4 Gnat1 Gng10 Prkcd Gnai3 Pomc Gnal Gnat3 Ppp2cb Gnao1 Adcy3 Ppp2ca Prkar2b Prkar2a Ppp2r1a Gnat2 Gnaz Gnai2 Gnb3 Gnb5 Ppp2r1b Gnb2 Gnb1 Gng13 Gng12 Gng11 Mapk1 Prkaca Prkacb Prkca LOC100912034 Gnb4 Camk4 Gng4 Adrbk1 Gngt2 Gnai1 Gng5 Gngt1 Gng8 Gng3 SIGNALING BY ERBB2%REACTOME%R-RNO-1227986.1 Signaling by ERBB2 Prkcd Ptpn18 Ereg Rnf41 Nrg1 Src Kras Btc Grb7 LOC102552659 Erbb3 Pik3r1 Erbb2 Nrg3 Matk Egfr Hbegf Akt1 Ptk6 Nrg4 Memo1 Stub1 Gab1 Fyn LOC103692716 Akt3 Diaph1 Rhoa Prkca Erbb4 Hras Yes1 Nras Sos1 Ptpn12 Usp8 Shc1 Akt2 Nrg2 Grb2 PHASE 0 - RAPID DEPOLARISATION%REACTOME DATABASE ID RELEASE 66%10146067 Phase 0 - rapid depolarisation Camk2g Cacna1c Cacng7 Cacna1d Cacng1 Camk2d Cacng5 Camk2a Scn2a Scn7a Scn4b Scn2b Fgf11 Scn9a Fgf12 Fgf13 Scn10a Scn4a Scn5a Fgf14 Scn3a Scn11a Rangrf Scn1b Cacnb4 Cacnb1 Cacng8 Cacnb2 Cacna2d3 Cacna1f Cacna1s Cacng2 Cacng3 Cacna2d2 Cacng4 Cacna2d4 MISCELLANEOUS SUBSTRATES%REACTOME DATABASE ID RELEASE 66%10145442 Miscellaneous substrates Cyp4a2 Cyp2s1 Cyp4f39 Cyp4a1 Cyp3a23/3a1 Cyp3a73 Cyp2d5 Cyp4f6 Cyp2u1 Cyp4a8 LOC100912391 Cyp2d4 Cyp3a18 Cyp4f17 LOC100910877 Cyp2d2 Cyp2d3 Cyp4f18 HATS ACETYLATE HISTONES%REACTOME%R-RNO-3214847.1 HATs acetylate histones Atf2 Phf20 Mcrs1 Hist1h2bo Kat7 Hist1h2bcl1 Kansl3 Hist2h3c2 Jade1 Hist1h2bk Jade3 Hat1 Jade2 Kat8 Msl3 Ogt Msl1 Ncoa1 Msl2 Meaf6 LOC100910200 Hist1h4b Wdr5 Pax3 LOC684841 Hist1h2bh LOC100912290 Rbbp7 Hist1h2ail1 Hist1h4m LOC102549173 LOC100912338 Msl3l2 Hist1h3c Hist1h3f Brpf3 Hist2h4 LOC684819 Hist1h3a Brpf1 Brd1 Hist1h2bq Kat6a Ing4 LOC100364835 LOC684762 Ing5 Ncoa2 Hist1h2bg LOC680097 LOC684797 LOC100912418 Hist1h2ba Hist3h2bb REGULATION OF IFNA SIGNALING%REACTOME%R-RNO-912694.1 Regulation of IFNA signaling Stat1 Jak1 Stat2 Ptpn1 Ifnar2 Ifna5 Ifna4 Ptpn11 LOC100912356 LOC100911527 Ifna11 Ptpn6 LOC100912859 Usp18 Ifnar1 RGD1560539 Ifna2 Ifnb1 LOC103690314 LOC100912314 Tyk2 Ifna16l1 RGD1565911 RGD1561827 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES%REACTOME%R-RNO-1169410.1 Antiviral mechanism by IFN-stimulated genes LOC100912571 Stat1 Irf3 Jak1 Eif4e2 Pde12 Arih1 Oasl Rnasel Abce1 Ddx58 Uba7 LOC100911431 Ube2l6 Eif4g1 Eif4a3 Eif4g2 Eif4g3 Flnb Isg15 Trim25 Eif2ak2 Ppm1b Usp18 Ube2n Eif4e3 Plcg1 Mx1 Eif4a2 Mx2 Eif4a1 LOC680559 SIGNALING BY NOTCH4%REACTOME DATABASE ID RELEASE 66%10146330 Signaling by NOTCH4 Ywhaz Notch4 Akt1 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM%REACTOME DATABASE ID RELEASE 66%10144804 Cobalamin (Cbl, vitamin B12) transport and metabolism LOC102554637 Mtrr Try4 Prss2 Mtr LOC103690254 Mut LOC688708 Try10 LOC100365995 Cubn Amn Mmadhc Abcd4 Cd320 Mmab Tcn2 Mmaa Mmachc Prss1 LOC683849 Ctrc Lmbrd1 ASSEMBLY OF ACTIVE LPL AND LIPC LIPASE COMPLEXES%REACTOME DATABASE ID RELEASE 66%10146149 Assembly of active LPL and LIPC lipase complexes Angptl4 LOC100361444 Lmf1 Lmf2 Lpl Gpihbp1 Pcsk6 Pcsk5 Furin SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX)%REACTOME%R-RNO-2162123.1 Synthesis of Prostaglandins (PG) and Thromboxanes (TX) Ptgds Tbxas1 Ptgis Akr1c2 Akr1c12l1 Akr1c3 Ptges Ptges3 Cyp8b1 Ptges3l1 Cbr1 Ptges2 Hpgds LOC102556347 Akr1c19 Ptgs1 Akr1c13 Ptgs2 Akr1c14 RGD1564865 Akr1c12 Akr1c1 INTERLEUKIN-38 SIGNALING%REACTOME DATABASE ID RELEASE 66%10146291 Interleukin-38 signaling Il1rapl1 Mapk8 Il1rl2 Il1f10 AUF1 (HNRNP D0) BINDS AND DESTABILIZES MRNA%REACTOME DATABASE ID RELEASE 66%10145697 AUF1 (hnRNP D0) binds and destabilizes mRNA LOC100912571 Psmc6 Psmb10 Psmb8 Psmb9 Psmb4 Psmb11 Psmb5 Psmf1 Psmb6 Psmd4 Psmb2 Psmd5 Psmd8 Psmd9 Psmb3 Psma8 Psmd11 Psmd12 Psmd13 Eif4g1 Psmd14 Pabpc2 Pabpc6 Psmc3 LOC680559 Hspb1 G6pc Psmb7 Psmb1 LOC100911431 Pabpc1 Hnrpd Psma5 Psma2 Psmc5 Psmd2 Psma1 Psma4 Psmc1 Psma3 Psmc4 Psmc2 Psma6 Psme1 Psmd1 Psme2 Psmd7 Psmd3 Psmd6 CYTOKINE SIGNALING IN IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 66%10145164 Cytokine Signaling in Immune system Il21r Il21 Pde12 Pias1 Oasl Rnasel Abce1 Rbx1 Socs5 Socs3 Uba7 Vamp2 Casp3 Ube2l6 Tnf Fyn Sumo1 Stat6 Il1rl2 Il36rn Il1f10 Il1rap Il36b Il36a Sqstm1 Stx4 Ube2n Ptk2b Il1rl1 Brwd1 Pik3cd Irak4 Crk Ifnar2 Ifna5 Stx1a Traf2 Ifna4 LOC100912356 LOC100911527 Ifna11 LOC100912859 Ifnar1 RGD1560539 Lyn Ifna2 Crkl Ifnb1 Yes1 LOC103690314 Hck LOC100912314 Rapgef1 Ifna16l1 RGD1565911 Syk RGD1561827 LOC100911248 Map2k7 Camk2g Ripk2 Tbk1 Map2k6 Ager Dusp3 Irf3 Map2k4 Map3k8 Dusp4 Peli3 Nfkbib Peli2 Camk2d Traf6 Cul1 Camk2a Vrk3 Rps6ka2 Rps6ka1 App Rps6ka3 Il33 Rps6ka5 Canx LOC100912585 Tab1 Dusp7 Dusp6 Rela Atf1 Atf2 Map3k7 Peli1 Irak2 Traf3 Ptpn2 Nfkbia LOC100910771 Usp18 Irf9 Tnfsf13b Tnfrsf9 Tnfrsf8 Il2rg Edaradd Tnfrsf4 G6pc Eda2r Ifngr2 Ifngr1 Cd70 Tnfrsf17 Tnfsf8 Tnfsf9 Tnfrsf25 Edar Psmb7 Prmt2 Psmb1 Tnfrsf11b Tnfrsf11a Tnfsf4 Tnfsf14 Tnfsf12 Tnfrsf12a Tnfrsf13c Eda Tnfsf11 Lta Ltb Vav1 Ltbr Il9r Cd27 Il15 Ifng Il9 P4hb Psma5 Tollip Sos2 Psma2 Il10ra Il10 Il5 Psmd2 Il2 Ptpn6 Psmc2 Il2ra Psmd1 Csf2 Il3ra Psmd7 Psmd3 Il2rb Psmd6 LOC100912571 Psmc6 Csf2ra Csf2rb Psmb10 Psmb8 Psmb9 Psmb4 Sh2b1 Psmb11 Ptpn1 Psmb5 Gh1 Psmf1 Il5ra Ghr Psmb6 Psmd4 Psmb2 Psmd5 Psmd8 Psmd9 Psmb3 Psma8 Prl Psmd11 Psmd12 Psmd13 Psmd14 Eif4g1 Csf1 Psmc3 Il1b Eif4a2 Eif4a1 LOC680559 Pik3r3 Inpp5d Jun Ppp2cb Ppp2ca Skp1 Ppp2r1a Ywhaz Nfkb2 Nfkb1 Mapk9 Mapk8 Fos S100b Mapk7 Dhx9 Fbxw11 Chuk Ppp2r1b Mapkapk3 Eif4a3 Btrc Mapkapk2 Mapk1 Nkiras1 Prkaca LOC100362142 Nod1 Nod2 Nkiras2 Creb1 Tab2 Tab3 LOC100912618 Ube2v1 Ikbkb Mapk14 Myd88 Tnip2 Mapk11 Tnfsf13 Mapk10 Stat5a Jak3 Il22 Il24 Il19 Stat1 Il22ra1 Jak1 Cd40 Stat2 Stat3 Il10rb Hsp90b1 Cd4 Hist2h3c2 Cd40lg Irs2 Ube2m Cbl Smarca4 Il13ra1 Eif4g2 Clcf1 Eif4g3 Flnb Il13ra2 Isg15 Trim25 Il12b Eif2ak2 Il31ra Ppm1b Irak3 Eif4e3 Il12a Mx1 Il22ra2 LOC100360218 Mx2 Cntf Il20ra Irs1 Csf3 Il20rb Il23r Il1r1 Tyk2 Crlf2 Ifnl3 Il20 Ebi3 Ifnlr1 Il4r Prkcd Il17c Il1rapl1 Map3k3 Il17a Birc3 Il23a Birc2 Crlf1 LOC684841 Il4 Pik3r1 Il6 Lif Il6st Pik3r2 Stxbp2 Eif4e2 Csf1r Arih1 Ptprz1 Hist1h2ail1 Il13 LOC102549173 Tnfrsf14 Txlna Il11ra1 Lifr Il18r1 Il12rb1 Ddx58 Hist1h3c Il12rb2 Csf3r Hist1h3f Il17rc Il11 Stx3 Il18 LOC684819 Hist1h3a Il16 Ctf1 LOC100911431 Il1a Casp1 Il25 Osmr Il17rb Il17ra Il17re Il27ra LOC684762 Socs1 Cntfr Osm Tnfrsf1b Psmc5 Psma1 Uba3 Pik3cb Map3k14 Psma4 Ptpn11 Relb Psmc1 Tec Psma3 Psmc4 Psma6 Psme1 Plcg1 Psme2 Sos1 Vamp7 Shc1 Grb2 FORMATION OF A POOL OF FREE 40S SUBUNITS%REACTOME%R-RNO-72689.1 Formation of a pool of free 40S subunits Eif3l Eif3m Eif3j Eif3k Rps20 Rps27l Eif3e Eif3f Eif3b Eif3a Eif3d Eif3c Rps16 LOC100360573 Rps18 LOC100360679 Rps15 Rps4x Rps3a LOC100359951 LOC100359593 LOC100359503 LOC100362640 Rps3 Rps15a Rps2 Rps13 Rps12 LOC100911372 LOC100361854 LOC684988 LOC103689992 Rps5 Rps7 Rps6 Eif3g Eif3h LOC100362830 Eif1ax LOC100363012 LOC100911110 LOC100362149 LRR FLII-INTERACTING PROTEIN 1 (LRRFIP1) ACTIVATES TYPE I IFN PRODUCTION%REACTOME%R-RNO-3134973.1 LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production Irf3 Crebbp DISSOLUTION OF FIBRIN CLOT%REACTOME DATABASE ID RELEASE 66%10145082 Dissolution of Fibrin Clot Plau Plaur Serpinb8 Plg Serpine2 Plat S100a10 Serpine1 Serpinb2 Serpinb6b Serpinb6 Anxa2 RESOLUTION OF D-LOOP STRUCTURES THROUGH HOLLIDAY JUNCTION INTERMEDIATES%REACTOME%R-RNO-5693568.1 Resolution of D-loop Structures through Holliday Junction Intermediates Bard1 Wrn Rbbp8 Rmi1 Rmi2 Rad51c LOC100911267 Rad51d Spidr Rad51 Eme2 Brca2 Eme1 Rad50 Atm Brca1 Xrcc3 Blm Slx4 Mus81 Slx1b Slc25a16 Palb2 Gen1 Xrcc2 Nbn Mre11a RETINOID METABOLISM AND TRANSPORT%REACTOME DATABASE ID RELEASE 66%10145777 Retinoid metabolism and transport Agrn Gpihbp1 Pnlip Akr1b7 Akr1b8 Apoa1 Sdc2 Sdc3 Sdc4 Clps Gpc6 Akr1c2 Gpc4 Gpc2 Rbp4 Akr1c12l1 Akr1c3 Ttr Lrp1 Lrp10 Rbp2 Tex12 Rbp1 Lrp8 Apom Lrp12 Lpl Akr1c19 Apob Bco1 Apoc2 Rdh11 Apoe Apoa2 Lrat Bco2 Gpc1 Akr1c13 Akr1c14 RGD1564865 Akr1c12 Akr1c1 METABOLISM OF VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 66%10144806 Metabolism of vitamins and cofactors Nos3 Mmadhc Abcd4 Sdc2 Slc46a1 Sdc3 Cd320 Sdc4 Mmab Tcn2 Mmachc LOC683849 Ctrc Lmbrd1 Spr Akr1c12l1 Ttr Akr1c19 Akr1c13 Akr1c14 RGD1564865 Akr1c12 Fasn Acacb Slc5a6 Nnmt Nt5e Mccc2 Pdzd11 Mtrr Hlcs Pnlip Mccc1 Gsto1 Mtr LOC103690254 Akt1 Mut Try10 LOC100365995 Cubn Amn Apoa1 Clps Gpc6 Gpc4 Gpc2 Naprt1 Ptgs2 Gpc1 Mmaa Ptgis Try4 Pdss2 Coq2 LOC688708 Rfk Akr1b7 Pdxk LOC100911034 Akr1b8 Pts Apoa1bp Gsto2 Vnn1 Tpk1 Rnls Carkd Slc52a2 Slc52a3 Slc23a2 Pc Gch1 Nampt Mocs1 Cd38 Enpp1 Parp14 LOC100910173 Nudt12 Akr1c2 Nmnat2 Nmnat1 Acp5 Mocos Akr1c3 Ubiad1 Nmrk1 LOC103692716 Nmrk2 Prss2 Nfs1 Nadsyn1 Cyb5a Gchfr Pank4 Flad1 Parp9 Coasy Mocs3 Pank3 Pank2 Parp6 RGD1563242 Apob Ppcs Pank1 Apoc2 Thtpa Parp8 Apoe LOC100362038 Qprt Apoa2 Aasdhppt Folr2 Slc19a2 Nadk Prss1 Akr1c1 Slc25a19 Agrn Aox1 Pnpo Gpihbp1 Ppcdc Prkg2 Mthfs Mthfd1l Mthfd2l LOC102554637 Dhfr Mthfr Slc5a8 Mthfd2 Rbp4 Mthfd1 Shmt1 Aldh1l2 Lrp1 Aldh1l1 Lrp10 Slc19a1 Rbp2 Tex12 Slc25a32 Cyp8b1 Shmt2 Rbp1 Lrp8 Ttpa Apom Idh1 Lrp12 Lpl Bst1 Bco1 Rdh11 Lrat Pccb Slc2a1 Cyb5r3 Bco2 FIBRONECTIN MATRIX FORMATION%REACTOME%R-RNO-1566977.1 Fibronectin matrix formation Fn1 Ceacam1 Ceacam10 RMTS METHYLATE HISTONE ARGININES%REACTOME%R-RNO-3214858.1 RMTs methylate histone arginines Prmt3 Prmt5 Prmt6 Prmt7 Actl6a Hist2h3c2 Carm1 Rps2 Smarca4 Prmt1 Smarca2 LOC100911617 Arid2 Smarcc1 Smarcc2 Coprs Smarcb1 Actl6b H2afx Hist1h2aa Hist1h4b Smarce1 Wdr5 Pbrm1 LOC684841 Arid1b Arid1a LOC100912290 Rbbp7 Hist1h2ail1 Hist1h4m LOC102549173 Cdk4 LOC103690002 LOC100910152 Dnmt3a Smarcd1 Hist1h3c Smarcd2 H2afb3 Smarcd3 Hist1h3f Hist2h4 Ccnd1 LOC684819 Hist1h3a H2afj Hist2h2aa3 LOC100911453 Hist2h2aa2 Wdr77 LOC684762 LOC680097 LOC100912418 AMPK INHIBITS CHREBP TRANSCRIPTIONAL ACTIVATION ACTIVITY%REACTOME DATABASE ID RELEASE 66%10145123 AMPK inhibits chREBP transcriptional activation activity Adipor1 Adipor2 Adipoq Prkab2 Prkaa2 MAPK FAMILY SIGNALING CASCADES%REACTOME%R-RNO-5683057.1 MAPK family signaling cascades Ereg Nrg1 Btc LOC102552659 Erbb3 Erbb2 Nrg3 Egfr Hbegf Nrg4 Fyn Mapkapk5 Ptk2 Nrg2 Hspb1 Shc2 Ranbp9 Pdgfa Pdgfb Foxo1 Foxo3 Cdc14a Tln1 Vwf Apbb1ip Rasa1 Dlg4 Grin2d Camk2g Grin2b Grin1 Nefl Rasgrf1 Dusp4 Dlg1 Dlg2 Frs3 Dlg3 Camk2d Actn2 Camk2a Dusp7 Dusp6 Fgb Ret Fgg LOC100909468 Hgf Xpo1 Pak2 Pak3 Fga Pak1 Gdnf Map2k2 Pspn Cdc14b Mapk4 Cdc42ep5 Cdc42ep3 Ppp2r5e Etv4 Il2rg Cdc42ep2 G6pc Pdgfra Pdgfrb Mapk6 Psmb7 Psmb1 Ppp2r5c Spta1 Lrrc7 Ppp2r5a Kalrn Gfra4 Gfra3 Ppp2r5b Gfra2 Pbp2 Fn1 Artn Dusp9 Dusp2 Shc3 Dusp5 Nrtn Ptpra Rasal3 Psma5 Csk Rasal1 Rasal2 Rasgrp1 Rap1a Ncam1 Pebp1 Sptbn1 Rasgrp4 Rasgrp3 Pea15 Dusp1 Mark3 Psma2 Araf Cdc42 Rasa4 Il5 Psmd2 Spred1 Spred2 Rasgef1a Il2 Psmc2 Rasa2 Rasa3 Itga2b Il2ra Csf2 Psmd1 Il3ra Psmd7 Nf1 Iqgap1 Kit Syngap1 Kitlg Psmd3 Il2rb Psmd6 Dusp16 Map3k11 Psmc6 Csf2ra Csf2rb Psmb10 Ksr1 Rapgef2 Psmb8 Wdr83 Psmb9 Ksr2 Raf1 Psmb4 Ppp5c Psmb11 Il17rd Psmb5 Psmf1 Il5ra Cnksr1 Psmb6 Cnksr2 Rac1 Psmd4 Dusp10 Psmb2 Paqr3 Psmd5 Psmd8 Psmd9 Psmb3 Psma8 Psmd11 Psmd12 Psmd13 Psmd14 Fgf2 Psmc3 Src Dnajb1 Ppp2cb Ppp2ca Ppp2r1a Ywhab Ppp2r1b Mapk1 Prkaca Prkacb Jak3 Jak1 Vcl Sptan1 Fgf23 Fgf22 Fgf4 Fgf1 Fgf3 Fgf6 Fgf5 Lamtor3 Fgf20 Fgf16 Lamtor2 Fgf17 Irs2 Fgf10 Fgf9 Fgfr2 Fgf7 Fgf8 Fgfr3 Fgfr1 Fgfr4 Fgf19 Erbb4 Irs1 Frs2 Tyk2 Ccnd3 Kras Il6st Il6 Cdk1 Psmc5 Arrb1 Psma1 Tek Psma4 Psmc1 Arrb2 Ptpn11 Psma3 Psmc4 Lat Psma6 Psme1 Angpt1 Psme2 Hras Nras Sos1 Shc1 Grb2 ACTIVATION OF NIMA KINASES NEK9, NEK6, NEK7%REACTOME%R-RNO-2980767.1 Activation of NIMA Kinases NEK9, NEK6, NEK7 Nek6 Cdk1 Nek7 CYSTEINE FORMATION FROM HOMOCYSTEINE%REACTOME%R-RNO-1614603.1 Cysteine formation from homocysteine Cbs Cth NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION)%REACTOME%R-RNO-198725.1 Nuclear Events (kinase and transcription factor activation) Dusp3 Mapk7 Dusp4 Ppp2r1b Mapkapk2 Mapk1 Vrk3 Rps6ka2 Rps6ka1 Rps6ka3 Ppp2cb Rps6ka5 Creb1 Ppp2ca LOC100912585 Ppp2r1a Dusp7 Dusp6 Atf1 Mapk14 Mapk11 PYRIMIDINE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 66%10144841 Pyrimidine biosynthesis Cad Umps Dhodh ADAPTIVE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 66%10145356 Adaptive Immune System Rnf41 Kif3c Racgap1 Kif22 Kif3b Vhl Kif23 Stim1 Kifap3 Kif11 Kif4a Rbx1 Socs3 RGD1308751 Itga4 Dnm2 Rbck1 Fyn Ube2v2 Ube2n Rap1gap2 Sipa1 Pik3ap1 Ube2d1 Vcam1 Akt1 Herc2 Ube2d3 Stub1 Calr MGC114246 Cd101 Testin Kif26a Kif20a Lyn Yes1 Syk Trim21 Map3k8 Trim32 Nfkbib Traf6 Itgb7 Cul1 Madcam1 Itgb2 Wwp1 Atg7 Canx Rela Map3k7 Ctsa Ptprc Prkcq Siah1 Siah2 Vamp8 LOC100364523 Sar1b Sh3gl2 Nfkbia LOC100910771 Sh3kbp1 Itgal LOC685953 Icam4 Cd36 Ctsc Icam5 Icam1 Rap1gap Ctsd Psmb7 Ctsb Psmb1 Trem2 Ctsl Ctsm Ctsj RGD1564657 Ctsk Ctsq Vav1 Ctsr Psma5 Csk Dnm1 Dnm3 Rap1a Rasgrp1 Rasgrp3 Psma2 Psmd2 Cts8 Cts7 Ptpn6 Psmc2 Psmd1 Psmd7 RGD1564827 Ppl Icam2 Psmd3 Psmd6 Pten Raf1 Fbxl19 Fbxl12 Fbxl13 Fbxl16 Fbxl15 Cts8l1 Rasgrp2 Ube2z Kif3a Ube2s Fbxl4 Fbxl5 Fbxl8 Pik3r3 Inpp5d Cd3e Ppp2cb RT1-Ba Ppp2ca RT1-Bb Skp1 RT1-Da RT1-Db2 Ppp2r1a RT1-Db1 LOC688090 Mtor Nfkb1 Fbxw11 Chuk Ppp2r1b Mlst8 Btrc Akt3 LOC100362142 Tab2 LOC100912618 Ube2v1 Ikbkb Cd80 Cd86 Lgmn Colec12 Ap1m2 Trem1 Ifitm3 Cd40lg Cd226 Smurf1 LOC100911324 Pvrl2 Ifitm2 Ifitm1 Sh2d1a Sh2d1b Ube2m Cd8b Cd8a RGD1561143 Slamf7 Siglec10 Slamf6 Npdc1 Treml2 Cd200r1 Cd200r1l LOC681182 Cd96 Dctn1 Dctn2 Dctn3 RT1-DMa RT1-DMb Cd74 Lag3 Rilp Ifi30 LOC100909593 LOC100909630 RT1-DOb RT1-DOa Ctse Ctsf RGD1560225 Ppp3ca Nfatc2 Lat Plcg1 Nfatc3 Actr1a Lcp2 Itk Klc1 Sec24a Sec24b Dync1li2 Sec24d Asb18 Asb11 Asb12 Asb13 Asb14 Dync1i2 Asb10 Keap1 Uba7 Nck1 Traf7 Asb15 Glmn Asb17 Uba5 Asb16 Hecw2 Klc4 Mrc2 Ube2l6 Rbbp6 Mrc1 Cenpe Ube3d Klc2 Ube3b Trim11 Klc3 Lrsam1 Ube3a Npepps Ube2o Ube2u Hectd3 RT1-A2 Hectd1 Rnf6 RT1-A1 Erap1 Ncf1 Ncf4 Rnf4 Cd207 B2m Tap1 Tap2 Traip Rnf25 Ap1b1 Anapc13 RGD1561778 Lnx1 Dynll2 Rnf19a Rnf19b Herc3 Arih2 Herc6 Tapbp Stx4 Tpp2 Dync1i1 Ubox5 Ube2j2 Arel1 Ube2j1 Sec24c Rnf182 Rnf14 Ltn1 Cblb Sh3rf1 Pja1 Pja2 Dtx3l LOC100911393 Znrf2 Znrf1 Trim9 Blmh LOC100911400 Rnf115 Ptpn22 Trim63 Dzip3 Trip12 Ubr2 Trim71 Vprbp Trim69 Trim39 Ube4a LOC100910646 Ufl1 Trim50 Ubac1 Ube2q1 Thop1 Rlim Mex3c Rchy1 Pik3cd Mgrn1 Trim41 Hace1 Trim36 Trim37 Anapc7 Fcgr1a Cdc26 Cd247 Cdc27 Cdc23 Fbxl22 Rnf144b Lrrc41 Ube2c Skp2 Fbxw10 Cdc16 Fbxw12 Anapc4 Anapc2 Anapc1 Ap1s3 Ap1s1 Ap1s2 Fyb Anapc11 Anapc10 Fzr1 Cd19 Cd81 LOC100909468 Sec13 Pak2 Pak3 Pak1 Ppp2r5e G6pc Klhl5 Cdc20 Kif2a Kif2c Kif2b Kif18a Ppp2r5c Ppp2r5a Ppp2r5b Xdh Capzb Cd209b Kif5b Cd209e Klhl2 Btn2a2 Kif5a Clec4m Fbxo2 Cd79b Cd79a Fbxo9 Was Nfkbie Blnk Fbxo7 Btn1a1 LOC684480 Fbxo6 Cd209a Fbxo4 Btnl2 Dapp1 Cd79al Ube2k Ube2h Ube2f Sec31a Pdpk1 Ube2a Cdc42 Klhl9 Lrr1 Psmc6 Psmb10 Psmb8 Psmb9 Rnf123 Psmb4 Psmb11 Psmb5 Psmf1 Psmb6 Psmd4 Rac1 Psmb2 Psmd5 Psmd8 Psmd9 Psmb3 Psma8 Ccnf Psmd11 Psmd12 Ube2e3 Psmd13 Psmd14 Rictor Ap2a2 RT1-M3-1 Tceb2 Tceb1 Cul2 Psmc3 LOC100364500 RT1-S3 Bcl10 RT1-CE2 Kctd7 Src RT1-CE3 RT1-CE4 RT1-CE7 Rnf7 RT1-CE5 RT1-CE10 Cltc Rab7a Clta Prkcb Ywhaz Ap2s1 Kbtbd8 Ppp3r1 Kbtbd7 Ap2a1 Ywhab Kbtbd6 Ap2m1 Kctd6 Ube2q2 Ube2r2 Hspa5 Capza2 Capza3 LOC683761 Gan LOC100364956 Prkaca Prkacb Itpr1 Rapgef4 Itpr3 PVR Cd40 Cd34 Fbxl18 Siglec1 Mill1 Fbxl7 LOC680910 LOC685157 Cd200 Hcst Cd300lb Asb5 Cd300le Asb6 Kir3dl1 Asb7 Pianp Klhl41 Cd300e Cd300lg Asb1 Asb3 Cd1d1 Cd300lf Cdc34 Cd4 Asb8 Crtam LOC685048 Actr10 RGD1559588 Sh2d1b2 Klhl42 Pilra RT1-A Cd22 RGD1566006 LOC685438 Dync1h1 Dync1li1 Fbxo41 Fbxo44 Fbxo40 RGD1565355 Trib3 Cybb Cyba Wsb1 Actr1b Dctn5 RT1-M2 Dctn6 Spsb2 RT1-M5 Spsb1 RT1-M4 Ubr4 Them4 Dctn4 Spsb4 Btbd1 Akt2 Btbd6 Fbxo22 Ube2g2 Ube2g1 Kras Pik3r1 Pik3r2 Klhl13 Fbxo30 Pdcd1lg2 Fbxo31 Tnfrsf14 Klhl11 Ptprj Btla Fbxo32 Fbxo21 Icoslg Cd28 Pdcd1 Klhl20 Ap1m1 Cd274 LOC100911478 Icos Zbtb16 Klhl25 Klhl21 Uba1 Klhl22 Fbxo10 Socs1 Fbxo15 Fbxo11 Sec22b Sec23a RGD1559482 Fbxw2 C3 Mylip RT1-M6-1 Uba6 Lair1 Rnf34 Mapkap1 Psmc5 Cd3g Fbxw9 Psma1 Pik3cb Uba3 Psma4 RT1-M6-2 Map3k14 Psmc1 Ptpn11 Cd3d Fbxw5 Psma3 Fbxw4 Psmc4 Fbxw8 Psma6 Fbxw7 Psme1 Psme2 Hras Nras Sos1 Vamp3 LOC100909844 Grb2 RAF-INDEPENDENT MAPK1 3 ACTIVATION%REACTOME DATABASE ID RELEASE 66%10144960 RAF-independent MAPK1 3 activation Dusp16 Dusp9 Dusp2 Dusp5 Jak1 Il6st Dusp4 Il6 Cdk1 Pea15 Dusp1 Dusp10 Mapk1 Ptpn11 Dusp7 Dusp6 Tyk2 Map2k2 RNA POLYMERASE II TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 66%10144832 RNA Polymerase II Transcription Termination Rnps1 Thoc5 Thoc7 Thoc3 Snrpf Thoc2 Thoc1 Wdr33 Magohb Rbm8a Pcf11 Fip1l1 Thoc6 Nudt21 Zfp473 Snrpd3 Ddx39a Cstf2 Ddx39b Chtop U2af1l4 Cpsf7 Cpsf2 Cpsf3 Cpsf4 Cstf1 Cpsf1 Sarnp Slu7 Srsf3 Upf3b U2af2 Papola Srsf6 Srsf7 Srsf4 Lsm10 Lsm11 Srsf5 Srsf2 LOC679894 Srsf9 Dhx38 Clp1 Magoh Ncbp2 Srsf1 Poldip3 Ncbp1 Cstf2t Eif4a3 Fyttd1 Sympk Slbp LOC100910660 Srrm1 Cdc40 LOC361990 Snrpb SYNTHESIS OF KETONE BODIES%REACTOME%R-RNO-77111.1 Synthesis of Ketone Bodies Hmgcll1 Aacs Bdh2 Acat1 Hmgcs2 Hmgcl Acss3 LACTOSE SYNTHESIS%REACTOME DATABASE ID RELEASE 66%10146097 Lactose synthesis Slc2a1 Lalba B4galt1 DOWNSTREAM SIGNALING OF ACTIVATED FGFR4%REACTOME DATABASE ID RELEASE 66%10145261 Downstream signaling of activated FGFR4 Kras Pik3r1 Frs3 Fgf23 Fgf22 Fgf4 Fgf1 Fgf3 Fgf6 Fgf5 Fgf20 Gab1 Fgf16 Fgf17 Fgf10 Fgf9 Fgfr2 Fgf7 Fgf2 Fgf8 Fgfr3 Fgfr1 Fgfr4 Ptpn11 Plcg1 Fgf19 Hras Nras Frs2 Sos1 Shc1 Grb2 VXPX CARGO-TARGETING TO CILIUM%REACTOME DATABASE ID RELEASE 66%10146083 VxPx cargo-targeting to cilium Exoc8 Exoc7 Rab11a Rab3ip Arf4 Pkd2 Pkd1 Rab8a Cnga4 Cnga2 Cngb1 Gbf1 Exoc3 Exoc2 Exoc1 Exoc6 Exoc5 THE ROLE OF GTSE1 IN G2 M PROGRESSION AFTER G2 CHECKPOINT%REACTOME%R-RNO-8852276.1 The role of GTSE1 in G2 M progression after G2 checkpoint Psmc6 Psmb10 Psmb8 Psmb9 Psmb4 Psmb11 Fkbpl Psmb5 Psmf1 Psmb6 Psmd4 Psmb2 Psmd5 Psmd8 Psmd9 Psmb3 Psma8 Psmd11 Psmd12 Psmd13 Psmd14 LOC103692716 Psmc3 G6pc Hsp90ab1 Psmb7 Psmb1 Psma5 Cdkn1a LOC100910954 Cdk1 Mapre1 Psma2 Psmc5 Gtse1 Psmd2 Psma1 Psma4 Psmc1 Psma3 Psmc4 Psmc2 Psma6 Psme1 Psmd1 Psme2 Psmd7 Psmd3 Psmd6 TWIK-RELATED SPINAL CORD K+ CHANNEL (TRESK)%REACTOME DATABASE ID RELEASE 66%10145846 TWIK-related spinal cord K+ channel (TRESK) Kcnk18 NEUROTRANSMITTER RELEASE CYCLE%REACTOME%R-RNO-112310.1 Neurotransmitter release cycle Slc6a11 Chat Slc6a13 Slc6a1 Slc6a12 Slc1a3 Slc1a7 Rab3a Slc1a6 Slc1a1 Rims1 Lin7c Cplx1 Lin7a Syn3 Syt1 Syn2 Vamp2 Stxbp1 Ppfia1 Slc32a1 Ppfia2 Ppfia3 Ppfia4 Bzrap1 Syn1 Apba1 Lin7b Dnajc5 Gad2 Slc38a2 Gad1 Slc17a7 Abat Aldh5a1 Naaa Stx1a Maoa Slc22a1 Slc22a2 Slc5a7 FREE FATTY ACID RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145661 Free fatty acid receptors Gpr31 Ffar2 Ffar3 Ffar1 MAPK1 (ERK2) ACTIVATION%REACTOME DATABASE ID RELEASE 66%10144963 MAPK1 (ERK2) activation Ptpn11 Il6st Jak1 Il6 Tyk2 Map2k2 Mapk1 PROCESSING AND ACTIVATION OF SUMO%REACTOME%R-RNO-3215018.1 Processing and activation of SUMO Senp2 LOC690251 Rwdd3 Senp1 Sumo1 Sae1 Ube2i Sumo3 Senp5 Uba2 RNA POLYMERASE II TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 66%10144905 RNA Polymerase II Transcription Initiation Gtf2h1 Gtf2h2 Gtf2e1 Gtf2e2 Mnat1 RGD1565904 Taf11 Polr2g Ercc3 Taf2 Polr2h Taf15 Polr2e Polr2f Polr2j Taf13 Taf9 Polr2k Taf12 Polr2d LOC100911822 Taf7 Polr2i Taf4b Polr2b Polr2c Taf3 Ercc2 Taf6 Polr2a Taf5 Gtf2f1 LOC100912534 Gtf2f2 Gtf2a1 Cdk7 Atp5c1 Taf10 Taf7l Gtf2b Ccnh Gtf2h3 Gtf2h5 Tbp Gtf2h4 Taf9b RUNX3 REGULATES WNT SIGNALING%REACTOME DATABASE ID RELEASE 66%10146277 RUNX3 regulates WNT signaling Tcf7 Lef1 Tcf7l1 FORMATION OF EDITOSOMES BY ADAR PROTEINS%REACTOME%R-RNO-77042.1 Formation of editosomes by ADAR proteins Adarb1 Adar ARACHIDONIC ACID METABOLISM%REACTOME%R-RNO-2142753.1 Arachidonic acid metabolism Cyp1b1 Cyp4a2 Ptgds Cyp4a1 Ptgis Dpep3 Aloxe3 Dpep1 Cyp4a8 LOC688708 Pla2g4a LOC102556347 Cyp2j10 Alox5ap Awat1 Akr1c2 Akr1c12l1 Akr1c3 Ptges3 Ptges3l1 Hpgds Akr1c19 Cyp4f17 Akr1c13 Akr1c14 RGD1564865 Akr1c12 Akr1c1 Cyp4f18 Tbxas1 Cyp4f39 Dpep2 Ptges Faah Ptges2 Pon3 Pon1 Pon2 Alox5 Lta4h LOC100361547 Gpx4 Cyp2u1 Cyp4f6 Mapkapk2 Cyp8b1 Cyp2c7 Cbr1 Alox15b Alox12 Ltc4s LOC100912391 Cyp1a1 Ptgs1 Ptgs2 Ephx2 Cyp1a2 Alox15 Cyp2c6v1 ION TRANSPORT BY P-TYPE ATPASES%REACTOME%R-RNO-936837.1 Ion transport by P-type ATPases Fxyd2 Camk2g Fxyd3 Fxyd4 Atp2b4 Pdzd11 Atp10b Atp11c Atp2b2 Sri Atp2b1 Sln Camk2d Camk2a Atp9b Atp7a Atp2a2 Fxyd6 Atp7b Atp10d Pln Fxyd7 Atp2a3 Atp1b3 Atp1b2 Atp1b1 Atp8b3 Atp8b2 Atp8b1 Atp8a1 Atp2c2 Atp2c1 Atp11a Atp12a Atp13a5 Atp13a4 Atp13a2 Atp8a2 Atp1a4 Atp4b Atp4a Atp1a1 Atp1a2 Atp13a1 Atp1a3 PI-3K CASCADE:FGFR4%REACTOME%R-RNO-5654720.1 PI-3K cascade:FGFR4 Gab1 Fgf16 Fgf17 Pik3r1 Fgf9 Fgf2 Fgf8 Fgfr4 Fgf23 Fgf4 Ptpn11 Fgf1 Fgf6 Fgf19 Frs2 Fgf20 Grb2 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS%REACTOME DATABASE ID RELEASE 66%10144984 SLBP independent Processing of Histone Pre-mRNAs Ncbp2 Snrpf Zfp473 Snrpd3 Ncbp1 Lsm10 Lsm11 Snrpb G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA%REACTOME%R-RNO-392451.1 G beta:gamma signalling through PI3Kgamma Pik3r5 Pik3r6 Gnb3 Gnb5 Gnb2 Gnb1 Akt1 Pdpk1 Gng13 Gng12 Gng11 Akt3 Rhoa LOC100912034 Gnb4 Gng4 Gngt2 Pik3cg Gng5 Gngt1 Gng10 Gng8 Akt2 Gng3 CLEC7A (DECTIN-1) SIGNALING%REACTOME%R-RNO-5607764.1 CLEC7A (Dectin-1) signaling Psmc6 Psmb10 Psmb8 Psmb9 Psmb4 Psmb11 Psmb5 Psmf1 Psmb6 Traf6 Psmd4 Psmb2 Cul1 Psmd5 Psmd8 Psmd9 Psmb3 Psma8 Psmd11 Cdc34 Psmd12 Tab1 Psmd13 Rela Psmd14 Map3k7 Ube2m Psmc3 Nfkbia Il1b LOC100910771 Ube2n Bcl10 Pycard Prkcd Src G6pc Ube2d1 Psmb7 Psmb1 Skp1 Ppp3r1 Casp8 Nfkb2 Nfkb1 Psma5 Fbxw11 Chuk Btrc Pdpk1 Psma2 RGD1560225 Psmc5 Ppp3ca Psma1 Psmd2 Uba3 LOC100362142 Psma4 Nfatc2 Map3k14 Psmc1 Relb Psma3 Psmc4 Psmc2 Tab2 Psma6 Tab3 Psme1 LOC100912618 Ube2v1 Psmd1 Psme2 Ikbkb Psmd7 Nfatc3 Psmd3 Psmd6 CELL-EXTRACELLULAR MATRIX INTERACTIONS%REACTOME DATABASE ID RELEASE 66%10145642 Cell-extracellular matrix interactions Arhgef6 Ilk Flna Rsu1 Vasp Fblim1 Fermt2 Flnc Actn1 Parvb Lims1 SODIUM PROTON EXCHANGERS%REACTOME%R-RNO-425986.1 Sodium Proton exchangers Slc9a1 Slc9a4 Slc9a5 Slc9a2 Slc9a9 Slc9a3 Slc9a6 Slc9a8 Slc9a7 INTERLEUKIN-7 SIGNALING%REACTOME%R-RNO-1266695.1 Interleukin-7 signaling Stat5a Jak3 Hist2h3c2 LOC684841 Il2rg Irs2 Pik3r3 Pik3r1 Jak1 Pik3r2 Stat3 Hist1h2ail1 Smarca4 LOC102549173 Brwd1 Hist1h3c Hist1h3f LOC684819 Hist1h3a Irs1 Crlf2 LOC684762 ATTACHMENT OF GPI ANCHOR TO UPAR%REACTOME DATABASE ID RELEASE 66%10145107 Attachment of GPI anchor to uPAR Pigk Plaur Pgap1 Pigs Gpaa1 Pigu Pigt ANTIGEN PROCESSING-CROSS PRESENTATION%REACTOME DATABASE ID RELEASE 66%10145813 Antigen processing-Cross presentation Psmc6 Psmb10 Psmb8 Psmb9 Psmb4 Psmb11 Psmb5 Psmf1 Psmb6 Psmd4 Psmb2 Psmd5 Psmd8 Psmd9 Psmb3 Psma8 Psmd11 Psmd12 Mrc2 Psmd13 Mrc1 Psmd14 RT1-A RT1-A2 RT1-M3-1 Ncf1 RT1-A1 Ncf4 Cd207 Tap1 B2m Tap2 RGD1565355 Cybb Cyba Vamp8 Psmc3 RT1-M2 LOC100364500 RT1-M5 Tapbp RT1-M4 Stx4 RT1-S3 LOC685953 RT1-CE2 Cd36 RT1-CE3 RT1-CE4 RT1-CE7 G6pc RT1-CE5 RT1-CE10 Psmb7 Psmb1 Fcgr1a Calr Psma5 Sec22b RT1-M6-1 LOC683761 Psma2 LOC100364956 Psmc5 Psmd2 Psma1 RT1-M6-2 Psma4 Psmc1 Psma3 Psmc4 Psmc2 Psma6 Psme1 Psmd1 Psme2 Psmd7 Vamp3 Psmd3 Psmd6 CALCITONIN-LIKE LIGAND RECEPTORS%REACTOME%R-RNO-419812.1 Calcitonin-like ligand receptors Ramp3 Adm Calcb Iapp Calca Ramp1 Adm2 Ramp2 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER%REACTOME%R-RNO-2173793.1 Transcriptional activity of SMAD2 SMAD3:SMAD4 heterotrimer Smad3 Ccnt2 Smad2 Usp9x Sp1 Ube2d1 Skil Rbl1 Ncor2 Cdk9 E2f4 Men1 Hdac1 Tgif2 Tgif1 Atp1b4 Trim33 Ccnk Ube2d3 Wwtr1 Tfdp1 Tfdp2 Parp1 E2f5 Hdac1l Snw1 P75NTR REGULATES AXONOGENESIS%REACTOME%R-RNO-193697.1 p75NTR regulates axonogenesis Ngf Rhoa Arhgdia Rtn4 Lingo1 Ngfr Omg Mag MET ACTIVATES PTPN11%REACTOME%R-RNO-8865999.1 MET activates PTPN11 Gab1 Hgf Ptpn11 Grb2 RUNX1 AND FOXP3 CONTROL THE DEVELOPMENT OF REGULATORY T LYMPHOCYTES (TREGS)%REACTOME%R-RNO-8877330.1 RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) Cbfb Foxp3 Runx1 BILE ACID AND BILE SALT METABOLISM%REACTOME%R-RNO-194068.1 Bile acid and bile salt metabolism Slco1a1 Nr1h4 Osbp Amacr Akr1d1 Cyp39a1 Slco1a4 Ptgis Slco1a2 Rxra Slco1b2 Fabp6 Acot8 Osbpl3 Slc21a4 Hsd17b4 Osbpl6 Osbpl9 Slc27a5 Osbpl7 Abcb11 Cyp7b1 Hsd3b7 Slco1a6 Acox2 Akr1c2 Ncoa2 Stard5 Ch25h Akr1c12l1 Akr1c3 Slc27a2 Cyp7a1 Baat Cyp46a1 Cyp8b1 Slc10a1 Akr1c19 Akr1c13 Akr1c14 RGD1564865 Slc10a2 Ncoa1 Akr1c12 Akr1c1 PREGNENOLONE BIOSYNTHESIS%REACTOME%R-RNO-196108.1 Pregnenolone biosynthesis Stard3nl Tspo Stard4 Bzrap1 Stard6 Star Akr1b1 Stard3 Fdx1l Fdxr Fdx1 CS DS DEGRADATION%REACTOME DATABASE ID RELEASE 66%10145885 CS DS degradation Vcan Ncan Bcan Hexb Hexa Arsb LOC100910284 Dcn LOC102550316 Hyal1 Cspg5 Cspg4 Idua PI AND PC TRANSPORT BETWEEN ER AND GOLGI MEMBRANES%REACTOME%R-RNO-1483196.1 PI and PC transport between ER and Golgi membranes Pitpnb REELIN SIGNALLING PATHWAY%REACTOME DATABASE ID RELEASE 66%10146225 Reelin signalling pathway Fyn Vldlr Dab1 Sh3kbp1 Reln MRNA EDITING: A TO I CONVERSION%REACTOME%R-RNO-75064.1 mRNA Editing: A to I Conversion Adarb1 Adar PHOSPHOLIPASE C-MEDIATED CASCADE; FGFR2%REACTOME DATABASE ID RELEASE 66%10146098 Phospholipase C-mediated cascade; FGFR2 Fgf16 Fgf17 Fgf10 Fgf9 Fgfr2 Fgf7 Fgf2 Fgf8 Fgf23 Fgf22 Fgf4 Fgf1 Fgf3 Fgf6 Plcg1 Fgf5 Fgf20 MITOCHONDRIAL CALCIUM ION TRANSPORT%REACTOME%R-RNO-8949215.1 Mitochondrial calcium ion transport Pmpcb Pmpca MGC94335 Afg3l2 Micu3 Stoml2 Micu2 Slc8b1 LOC100910779 Micu1 Yme1l1 Spg7 Phb2 LOC100362065 Ccdc109b Mcu MITOCHONDRIAL ABC TRANSPORTERS%REACTOME%R-RNO-1369007.1 Mitochondrial ABC transporters Abcb8 Abcb10 Abcb6 TERMINATION OF TRANSLESION DNA SYNTHESIS%REACTOME DATABASE ID RELEASE 66%10146096 Termination of translesion DNA synthesis Rfc1 Rfc2 Pole2 Pole4 Polh Ns5atp9 Uba7 Poli Usp43 Rev1 Rpa1 Rpa2 Ube2l6 Rpa3 Pole Pold2 Pold1 Pcna Pold4 Isg15 Trim25 Usp10 Rfc5 Rfc4 Rfc3 PEPTIDE HORMONE BIOSYNTHESIS%REACTOME%R-RNO-209952.1 Peptide hormone biosynthesis Lhb Fshb Pomc Inha Inhbc Pcsk1 Tshb Cga Inhba MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS%REACTOME%R-RNO-1362409.1 Mitochondrial iron-sulfur cluster biogenesis LOC100911034 Hscb Iscu Isca2 Isca1 Fdx1l Nfs1 Fdxr Fdx1 Lyrm4 Glrx5 SEROTONIN NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 66%10145528 Serotonin Neurotransmitter Release Cycle Rab3a Rims1 Cplx1 Stx1a Syn3 Syt1 Syn2 Vamp2 Stxbp1 Ppfia1 Ppfia2 Ppfia3 Ppfia4 Bzrap1 Syn1 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATION FROM THE CENTROSOME%REACTOME%R-RNO-380284.1 Loss of proteins required for interphase microtubule organization from the centrosome Dync1i2 Cep57 LOC691918 Haus3 Ninl Akap9 Ccp110 Dync1h1 Pafah1b1 LOC103692716 Dctn1 Cntrl Dctn2 Cep76 Pcm1 Cep78 LOC100911033 Cep164 Dctn3 Cep41 Ofd1 Sdccag8 Tubb5 Prkar2b Cenpj Ywhag Ppp2r1a Plk4 Ywhae LOC100912076 Tubg2 Haus2 Haus1 Haus5 Alms1 Clasp1 Haus4 Odf2 Tubb4a Cdk1 Nek2l1 Ssna1 Mapre1 Tubg1 Cep63 Prkaca Csnk1d Cep131 Tuba4a Cep250 Cep135 Csnk1e Ckap5 Cdk5rap2 Pcnt Nek2 Cep72 Sfi1 Cep70 Actr1a Nedd1 LECTIN PATHWAY OF COMPLEMENT ACTIVATION%REACTOME%R-RNO-166662.1 Lectin pathway of complement activation Masp2 Colec10 Colec11 FORMATION OF THE EARLY ELONGATION COMPLEX%REACTOME DATABASE ID RELEASE 66%10145012 Formation of the Early Elongation Complex Gtf2h1 Gtf2h2 Mnat1 RGD1565904 Ercc3 Polr2g Polr2h Polr2e Polr2f Polr2j Polr2k Polr2d Supt5h LOC100911822 Polr2i Polr2b Polr2c Ercc2 Polr2a Ncbp2 Gtf2f1 LOC100912534 Gtf2f2 Ncbp1 Supt4h1 Cdk7 Nelfe Nelfa Nelfb Ccnh Gtf2h3 Gtf2h5 Gtf2h4 PTK6 PROMOTES HIF1A STABILIZATION%REACTOME%R-RNO-8857538.1 PTK6 promotes HIF1A stabilization Lrrk2 Egfr Hbegf Hif1a Gpnmb Ptk6 METABOLISM OF STEROID HORMONES%REACTOME DATABASE ID RELEASE 66%10145319 Metabolism of steroid hormones Pomc Fdx1 Hsd17b3 Akr1b7 Lhb Akr1b8 Hsd17b1 Hsd17b2 Hsd3b1 Bzrap1 Stard6 Star Hsd3b2 Cyp19a1 Stard3 Fdx1l Cyp11b2 Stard3nl Stard4 Srd5a3 Akr1b1 LOC100911154 Cyp21a1 Fdxr Hsd17b14 Tspo Srd5a1 Srd5a2 Hsd3b Hsd11b2 Cga Hsd17b12 Hsd17b11 CHREBP ACTIVATES METABOLIC GENE EXPRESSION%REACTOME DATABASE ID RELEASE 66%10145124 ChREBP activates metabolic gene expression Acacb Agpat1 Acly Fasn UREA CYCLE%REACTOME DATABASE ID RELEASE 66%10144786 Urea cycle Nmral1 Ass1 Nags Otc Cps1 Slc25a2 Arg1 MRNA EDITING%REACTOME%R-RNO-75072.1 mRNA Editing Apobec1 Apobec2 A1cf Adarb1 Adar Apobec4 BETA OXIDATION OF LAUROYL-COA TO DECANOYL-COA-COA%REACTOME DATABASE ID RELEASE 66%10144931 Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA LOC100911186 Echs1 Hadh Acadl Hadha Hadhb CASP8 ACTIVITY IS INHIBITED%REACTOME%R-RNO-5218900.1 CASP8 activity is inhibited Faslg Traf2 Cflar Fadd Ripk1 Tradd Tnfsf10 Casp8 Fas PTK6 REGULATES CELL CYCLE%REACTOME DATABASE ID RELEASE 66%10146203 PTK6 Regulates Cell Cycle Cdk2 Ccnd1 Cdkn1b Ccne1 Cdk4 Ptk6 HYDROXYCARBOXYLIC ACID-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145664 Hydroxycarboxylic acid-binding receptors Hcar1 Hcar2 EFFECTS OF PIP2 HYDROLYSIS%REACTOME%R-RNO-114508.1 Effects of PIP2 hydrolysis Prkcd Dgkg Dgkd Dgke Dgka Dgkb Prkcq Dgkk Dgki Itpr1 Dgkz Itpr3 Dgkq Dgkh Mgll Trpc3 Abhd12 Trpc7 Daglb Abhd6 Prkch Trpc6 Dagla UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A%REACTOME DATABASE ID RELEASE 66%10144752 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A Psmc6 Psmb10 G6pc Psmb8 Psmb9 Psmb4 Psmb11 Psmb5 Psmf1 Psmb6 Psmd4 Psmb2 Psmd5 Psmd8 Psmb7 Psmd9 Psmb1 Psmb3 Psma8 Psmd11 Psmd12 Psmd13 Psmd14 Psma5 Chek2 Psma2 Psmc5 Psmc3 Psma1 Psmd2 Psma4 Psmc1 Cdc25a Psma3 Psmc4 Psmc2 Psma6 Psme1 Psmd1 Psme2 Psmd7 Psmd3 Psmd6 SYNTHESIS OF PS%REACTOME%R-RNO-1483101.1 Synthesis of PS Ptdss2 PHASE 4 - RESTING MEMBRANE POTENTIAL%REACTOME%R-RNO-5576886.1 Phase 4 - resting membrane potential Kcnj4 Kcnk16 Kcnk5 Kcnk18 Kcnk6 Kcnk7 Kcnj2 Kcnj14 Kcnk1 Kcnk12 Kcnk13 Kcnk2 Kcnk3 LOC100909725 Kcnk4 Kcnj12 Kcnk10 Kcnk9 Kcnk15 NOTCH3 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME DATABASE ID RELEASE 66%10145951 NOTCH3 Activation and Transmission of Signal to the Nucleus Aph1b Psenen Ybx1 Aph1a Dll4 Egfr Jag1 LOC100911293 Notch3 Psen2 Psen1 Ncstn BETA OXIDATION OF BUTANOYL-COA TO ACETYL-COA%REACTOME DATABASE ID RELEASE 66%10144935 Beta oxidation of butanoyl-CoA to acetyl-CoA LOC100911186 Echs1 Hadh Acads UNWINDING OF DNA%REACTOME%R-RNO-176974.1 Unwinding of DNA Gins3 Gins4 Gins1 Gins2 PKB-MEDIATED EVENTS%REACTOME%R-RNO-109703.1 PKB-mediated events Pde3b JOSEPHIN DOMAIN DUBS%REACTOME DATABASE ID RELEASE 66%10146138 Josephin domain DUBs Atxn3 Rad23a Rad23b Josd2 Josd1 Vcp HSP90 CHAPERONE CYCLE FOR SHRS%REACTOME DATABASE ID RELEASE 66%10146010 HSP90 chaperone cycle for SHRs Dnaja2 Dctn1 Dnaja4 Dnajb1 Dctn2 Dync1li2 Hspa1l Hsp90ab1 Fkbp5 Hspa2 Dctn3 Dync1i2 Capzb Actr10 Dync1h1 Dync1li1 Capza2 LOC103692716 Capza3 Ptges3 Stip1 Dynll2 Ptges3l1 Dctn5 Dctn6 Dync1i1 Fkbp4 Dctn4 Pgr Actr1a NEUROFASCIN INTERACTIONS%REACTOME%R-RNO-447043.1 Neurofascin interactions Nfasc Ank1 Nrcam Sdcbp COMPLEX I BIOGENESIS%REACTOME%R-RNO-6799198.1 Complex I biogenesis Ndufab1 Mt-nd4 Ndufa7l Mt-nd5 Ndufaf7 Ndufa7 LOC683884 Ndufaf5 Mt-nd6 Nubpl Mt-nd2 LOC100911483 Ndufb10 Ndufb11 Ndufa12 Ndufa11 Ndufa13 Ndufa10 Ndufb6 Ndufb3 LOC100912599 Ndufb5 LOC100361505 Ndufc2 Ndufb9 Ndufb4 Ndufb8 Ndufb7 Ndufaf3 Ndufaf1 Ndufa2 Ndufa5 Ndufaf4 Ndufa6 RGD1306782 Ndufa1 Ndufs3 Ndufs1 Ndufs4 Ndufs5 Ndufs2 Ndufs8 Ndufs6 Ndufs7 Timmdc1 LOC684509 Acad9 Ndufb2 LOC679739 LOC679195 LOC100910710 LOC680288 Ecsit LOC688963 Tmem126b LOC100363268 Ndufv3 LOC100361144 Ndufv1 Ndufv2 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+%REACTOME%R-RNO-76005.1 Response to elevated platelet cytosolic Ca2+ Stxbp3 Tex264 F13a1 Ola1 Psap Ly6g6f Ctsw Selp Serpina4 Pcyox1l Tor4a Islr Cdc37l1 Chid1 Fam3c Lhfpl2 Nhlrc2 Itih4 Mmrn1 Rarres2 Itih3 Lefty2 Ecm1 Serpine1 Anxa5 Tagln2 Gtpbp2 Timp3 Lefty1 LOC100910414 Lamp2 Plek Sccpdh Phactr2 Cfd Cd9 Kng1l1 A1bg Stx4 Tgfb2 F8 Tgfb1 Tgfb3 Pf4 Aplp2 Cd109 Figf Rab27b Vegfc Vegfb Brpf3 Apoa1 Pdgfa Pdgfb Prkcb Timp1 Abcc4 A2m Tln1 Vwf Actn4 Vegfa Habp4 Pcdh7 Apool Apoh Plg Wdr1 Srgn Prkca LOC100911881 Lgals3bp Sytl4 LOC100912012 Serpina3m Fermt3 Cyb5r1 Maged2 Vcl Sparc Sod1 Actn2 Gas6 Aldoa App Tf Flna Igf2 Igf1 Clu Cd63 Serping1 Fgb RGD1565355 Fgg Hgf Thbs1 Fga Aldoart2 Actn1 Qsox1 LOC685953 Cd36 Scg3 Stxbp2 Kng1 LOC299277 Kng2 Fn1 Ppbp Tuba4a Pros1 Itga2b GLUCONEOGENESIS%REACTOME%R-RNO-70263.1 Gluconeogenesis LOC100911625 Mdh2 G6pc Mdh1 Eno3 Gapdhs Eno1 Tpi1 Eno2 Aldoa Got1 Fbp1 Fbp2 Aldob Gpi Aldoc Slc25a1 Pgk2 G6pc3 Pc Pgk1 Got2 Slc37a2 Pgam1 Pgam2 Pck1 Aldoart2 Slc25a11 Slc37a1 Slc25a10 MAPK6 MAPK4 SIGNALING%REACTOME%R-RNO-5687128.1 MAPK6 MAPK4 signaling Psmc6 Psmb10 Psmb8 Psmb9 Psmb4 Psmb11 Psmb5 Psmf1 Psmb6 Psmd4 Rac1 Psmb2 Psmd5 Psmd8 Psmd9 Psmb3 Psma8 Psmd11 Psmd12 Psmd13 Psmd14 Psmc3 Mapkapk5 Xpo1 Pak2 Pak3 Pak1 Cdc14b Mapk4 Ccnd3 Hspb1 Cdc42ep5 Cdc42ep3 Dnajb1 Etv4 Cdc42ep2 G6pc Mapk6 Psmb7 Psmb1 Kalrn Foxo1 Foxo3 Cdc14a Psma5 Cdk1 Psma2 Cdc42 Prkaca Psmc5 Psmd2 Prkacb Psma1 Psma4 Psmc1 Psma3 Psmc4 Psmc2 Psma6 Psme1 Psmd1 Psme2 Psmd7 Psmd3 Psmd6 SIGNALING BY NUCLEAR RECEPTORS%REACTOME%R-RNO-9006931.1 Signaling by Nuclear Receptors Ppp5c Crabp1 Yy1 Rarg Esr2 RGD1565904 Sdr16c5 Polr2g Polr2h Polr2e Dhrs4 Polr2f Rdh14 Polr2j Rdh13 Polr2k Aldh8a1 Polr2d Fabp5 Polr2i Polr2b Kdm1a Polr2c Polr2a LOC100912534 Cpt1b Rdh10 Rdh16 LOC100365958 Cpt1a Akr1c12l1 Akr1c19 Rara Rarb Akr1c13 Akr1c14 RGD1564865 Akr1c12 Hsp90ab1 Sp1 Cdk9 Hdac1 Jun LOC100911822 Dhrs9 Fos Rxrg Mapk1 Dhrs3 Fkbp5 Med1 Rxra Ppard Atf2 Ppid Ppidl1 Hist1h2bo Cited1 Nr5a2 Hist1h2bcl1 Hist2h3c2 Gtf2f1 Hist1h2bk Gtf2f2 H3f3b Kdm4b Carm1 Akr1c2 Greb1 Usf1 Gtf2a1 Akr1c3 Foxa1 Bmyc LOC103692716 Ptges3 Hdac1l Prmt1 Zfp217 Ptges3l1 Esr1 Pou2f1 Cbfb Tle3 Gata3 Fkbp4 Ddx5 Erbb4 Crebbp Nrip1 Pgr Ncoa1 Tbp Akr1c1 Runx1 LOC100910200 H2afx Hist1h4b LOC684841 Hist1h2bh LOC100912290 Cyp26c1 Hist1h2ail1 Hist1h4m LOC102549173 LOC103690002 LOC100910152 Pdhb LOC100912338 Pdk3 Hist1h3c Pdk4 Pdk1 H2afb3 Hist1h3f Pdk2 LOC100365902 Hist2h4 LOC684819 Pdha2 Hist1h3a Pdha1 H2afj Pdhx Pdha1l1 Hist2h2aa3 Hist1h2bq Hist2h2aa2 LOC100364835 LOC684762 Ncoa2 Dlat Rdh11 Cyp26a1 Hist1h2bg Adh6 LOC680097 LOC684797 LOC100912418 Hist1h2ba Hist3h2bb Cyp26b1 Dld ENOS ACTIVATION%REACTOME DATABASE ID RELEASE 66%10145394 eNOS activation Nos3 Ddah2 Zdhhc21 Ddah1 Spr Cygb LOC103692716 Akt1 GABA RECEPTOR ACTIVATION%REACTOME%R-RNO-977443.1 GABA receptor activation Kcnj4 Kcnj6 Gnai3 Gnal Gnat3 Adcy3 Gabra5 Adcy8 Gabra6 Gabrb1 Adcy9 Gabrg2 Gabra1 Adcy5 Gabra2 Gnai2 Adcy4 Adcy7 Adcy6 Gnb3 Kcnj16 Gnb2 Gnb1 Gng12 Gabrr1 Kcnj2 Kcnj3 Kcnj15 Gabrr3 Gabrr2 Kcnj9 Kcnj5 Gng4 Gngt2 Gnai1 Gng5 Gabbr1 Gngt1 Kcnj12 Gng10 Gabbr2 Gng8 Gabra4 Gng3 Gabrb2 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR%REACTOME DATABASE ID RELEASE 66%10145809 Regulation of gene expression by Hypoxia-inducible Factor Epas1 Hif3a Crebbp Arnt Cited2 Hif1a STEROLS ARE 12-HYDROXYLATED BY CYP8B1%REACTOME%R-RNO-211994.1 Sterols are 12-hydroxylated by CYP8B1 Ptgis Cyp8b1 WNT LIGAND BIOGENESIS AND TRAFFICKING%REACTOME%R-RNO-3238698.1 WNT ligand biogenesis and trafficking Wnt8a Wnt9b Wnt9a Vps26a Wls Wnt5b Wnt8b Wnt5a Wnt3 Wnt7a Wnt1 Wnt2b Wnt11 Wnt7b Wnt4 Vps29 Wnt16 Vps35 Wnt3a Wnt10a Wnt6 MET RECEPTOR ACTIVATION%REACTOME DATABASE ID RELEASE 66%10146172 MET Receptor Activation Hgf Spint2 Hgfac Spint1 GPCR LIGAND BINDING%REACTOME DATABASE ID RELEASE 66%10145122 GPCR ligand binding Gpr39 Ffar1 Ptgir Kng1l1 Cmklr1 Gpr35 Ccr6 Pomc Chrm4 Oxtr Oxt LOC100909648 Avpr1b Avpr1a Opn1sw Oprl1 Tas2r144 Grm3 Ccl21 Casr Prokr2 Mc3r Grm1 Ccr5 Grm6 Gal Tas2r113 Ccr4 Grm2 Ccr3 Grm8 Gpr37 Ccl27 Tas2r114 Cckar Tas2r110 Gper1 Ccl20 Uts2r Prokr1 Ccl25 Gprc6a NMS Xcr1 Tas2r124 Cxcl16 Tas2r125 Pdyn Tas2r126 Prlhr Tas2r121 Ccr10 Tas2r103 Gpr37l1 Tas2r104 Tas2r123 Ccl19 Ccr7 Tas2r116 Ccr8 Tas2r140 Tas2r120 Cxcr3 Cxcl10 Tas2r102 Ccr9 Opn1mw Tas2r145 Cxcl11 Tas2r119 Ece2 Tas2r118 Ece1 Tas2r117 Xk Ghrh Ramp3 Sstr5 Vipr2 Brs3 Tas2r107 Npbwr1 Sct Tas2r108 C5ar2 Pyy Gip Tas2r105 Pnoc Gipr Tas2r106 Ccl5 Tas2r129 Pth1r Npy2r Iapp Tas2r109 Mc4r Crhr2 Tas2r136 Prok2 Gcgr Tas2r137 Tas1r1 Adgre1 Oprm1 Prok1 Crhr1 Tas2r135 Mchr1 Sstr1 Glp2r Tas2r13 Tas2r130 Pth2 Aplnr Ramp2 Sstr4 Tas1r3 Sstr2 Tas2r139 Ghrhr Cck Npy1r Apln Tacr3 Tacr2 Bdkrb1 Bdkrb2 Rln3 Npb Ppy Trh Ccl1 Npw Mc2r Gng10 Npy Nps Adra1a Tbxa2r Sstr3 Penk Adra1d C5ar1 Kng1 Kng2 Gphb5 Gnrhr Gpha2 Gnrh1 Fshr Htr4 Tshr Cxcr5 Htr7 Uts2b Npy5r Nmur2 Cxcr6 Oprd1 Lhcgr LOC100909513 LOC100360745 Htr6 Npff Npffr2 RGD1560028 Hcrt Psap Npffr1 Qrfp LOC100909783 Lhb Oxgr1 Ptgdr Ptgdr2 Sucnr1 Adra2b Adrb3 Hcrtr1 F2rl3 F2r Qrfpr F2 Cxcr2 Hcrtr2 Ptger2 Tshb Cga F2rl2 Hebp1 Uts2 Pth Fpr-rs6 Ntsr2 Sctr Trhr Adm Crhbp Nmu Fpr-rs3 Pf4 Calcb Mc5r Fpr2 Vip Ntsr1 Fpr3 Pmch Anxa1 Calca Ramp1 Rxfp1 Htr2c Adcyap1r1 Rxfp2 Htr2a Ucn Kel Fpr-rs4 Adcyap1 Insl3 Tac3 Ucn2 Kiss1 Pth2r Adm2 Rxfp3 Crh Tac1 Htr2b Lpar5 Edn2 S1pr1 Ednra S1pr5 Ednrb Ptafr S1pr4 Grp Edn3 S1pr3 Grpr Cx3cr1 Lpar1 Edn1 Lpar3 F2rl1 Lpar2 Sst Ackr4 S1pr2 Ackr3 Nmb Xcl1 Cxcl9 Cxcl6 Cx3cl1 Gpr31 Cxcl2 Rgr Cxcl1 Taar9 Gpr18 Gpr55 Gpr4 Hrh2 Fshb Htr5a Cxcl3 Taar6 Agt Gpr132 Gnb3 Cnr2 Taar5 Gpr143 Gnb5 Taar2 Opn3 Lppr1 Opn4 Gnb2 Cnr1 Htr1d Lppr4 Gnb1 Gng13 Htr1f Lppr5 Gng12 Htr1a Lppr2 Gng11 Htr1b Hrh1 Lppr3 Chrm1 Hrh4 Chrm5 Ptger3 Adora3 Gpr183 Agtr2 Mtnr1a Prlh Opn5 Galr1 LOC100909523 Ccrl2 LOC100912034 Nts Hcar1 Gnb4 Oprk1 Hcar2 Adora2a Cysltr2 Glp1r Gcg Adora2b Cysltr1 Drd5 Gpr65 Drd1 Gng4 Gpr68 Gngt2 LOC100911796 Drd4 Ptgfr Gng5 LOC100363178 Drd2 Gngt1 Adora1 Ptger1 Gng8 Chrm3 LOC100365814 Gng3 Agtr1b Agtr1a Fpr1 Chrm2 Ltb4r Ffar2 Ffar3 Ltb4r2 Avp Gabbr1 Gabbr2 C3ar1 P2ry6 Lpar6 P2ry4 P2ry1 Gpr17 Lpar4 Ptgdrl Cxcl12 P2ry12 Cxcr4 P2ry2 P2ry10 P2ry13 Adra2a Adra2c C3 Cckbr Ppbp Adrb2 Tacr1 TRIGLYCERIDE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 66%10144910 Triglyceride biosynthesis Gpam Mogat1 Lpin2 Gk Mogat2 Lpin3 Lpin1 Dgat2 Gk2 Dgat1 Gpat2 Agmo BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME%R-RNO-70895.1 Branched-chain amino acid catabolism Mccc2 Bckdhb Bckdk Bcat1 Hsd17b10 Bcat2 Mccc1 Acat1 Shmt1 Dbt Hibadh Auh Aldh6a1 Ivd Acadsb Hibch Tmlhe Dld Ppm1k NTRK2 ACTIVATES RAC1%REACTOME DATABASE ID RELEASE 66%10146322 NTRK2 activates RAC1 Gab1 Hgf Crk Crkl Dock7 Rac1 Grb2 LOC100911248 SIGNALING BY ERBB4%REACTOME%R-RNO-1236394.1 Signaling by ERBB4 Stat5a Ereg Nrg1 Src Kras Btc Aph1b Erbb3 Pik3r1 Psenen Aph1a Nrg3 LOC100911293 Egfr Psen2 Hbegf Psen1 Ncstn Nrg4 Wwp1 Esr1 Yap1 Hras Erbb4 Nras Sos1 Shc1 Nrg2 Grb2 DNA DAMAGE REVERSAL%REACTOME DATABASE ID RELEASE 66%10146231 DNA Damage Reversal Fto Alkbh5 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX%REACTOME%R-RNO-3769402.1 Deactivation of the beta-catenin transactivating complex Apc Akt1 Men1 Hdac1 Chd8 Ywhaz Xiap Ash2l Sox2 Sox7 Sox6 Sry Sox17 Ctnnbip1 Hdac1l Btrc Cby1 Sox13 Pygo2 Xpo1 Tle3 Tcf7 Lef1 Tcf7l1 Bcl9l Tle4 Sox9 Tle1 Tle2 Akt2 Pygo1 Rbbp5 RECRUITMENT AND ATM-MEDIATED PHOSPHORYLATION OF REPAIR AND SIGNALING PROTEINS AT DNA DOUBLE STRAND BREAKS%REACTOME DATABASE ID RELEASE 66%10144760 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Bard1 Ppp5c Bre Rad50 Brcc3 Pias4 Uimc1 Atm Hist1h2bo Hist1h2bcl1 Hist1h2bk LOC100909750 Kdm4b Kdm4a Sumo1 Brca1 Bap1 Mdc1 Ube2v2 Ube2n Ube2i Smarca5 Nbn Abl1 Mre11a LOC100910200 Whsc1 H2afx Hist1h4b Rnf8 Hist1h2bh LOC100912290 Eya3 Apbb1 Babam1 LOC686349 Tp53bp1 Eya2 Hist1h4m Eya4 LOC100912338 Herc2 Hist2h4 Hist1h2bq LOC100364835 Baz1b Mapk8 Fam175a LOC100910954 Chek2 Hist1h2bg LOC680097 LOC684797 LOC100912418 Hist1h2ba Hist3h2bb TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE%REACTOME%R-RNO-168179.1 Toll Like Receptor TLR1:TLR2 Cascade Map2k7 Ripk2 Map2k6 Ager Dusp3 Map2k4 Map3k8 Dusp4 Peli3 Nfkbib LOC100912399 Peli2 Map3k1 Traf6 Cul1 Vrk3 Rps6ka2 Rps6ka1 App Rps6ka3 Rps6ka5 Tirap LOC100912585 Tab1 Dusp7 Dusp6 Rela Atf1 Atf2 Map3k7 Peli1 Irak2 Nfkbia LOC100910771 Ube2n Jun Ppp2cb Ppp2ca Skp1 Ppp2r1a Nfkb2 Nfkb1 Mapk9 Mapk8 Fos S100b Mapk7 Dhx9 Fbxw11 Chuk Ppp2r1b Ecsit Mapkapk3 Btrc Mapkapk2 Mapk1 Nkiras1 LOC100362142 Nod1 Nod2 Nkiras2 Creb1 Tab2 Tab3 LOC100912618 Ube2v1 Ikbkb Mapk14 Myd88 Tnip2 Mapk11 Mapk10 HEDGEHOG 'OFF' STATE%REACTOME%R-RNO-5610787.1 Hedgehog 'off' state Psmc6 Psmb10 Psmb8 Psmb9 Psmb4 Psmb11 Psmb5 Psmf1 Psmb6 Psmd4 Psmb2 Rbx1 Cul1 Psmd5 Psmd8 Psmd9 Psmb3 Psma8 Psmd11 Psmd12 Psmd13 Psmd14 Adcy8 Rpgrip1l Adcy9 Adcy5 Adcy4 Adcy7 Adcy6 Prkar1b Prkar1a Smo Wdr35 Kif3a Ift88 Psmc3 Mks1 Csnk1a1 Sufu G6pc Ptch1 Ofd1 Psmb7 Psmb1 Gli1 Gli3 Gli2 Adcy3 Prkar2b Skp1 Prkar2a Ift122 Wdr19 Ttc21b Psma5 Btrc Psma2 Prkaca Psmc5 Ift52 Psmd2 Prkacb Psma1 Kif7 Psma4 Psmc1 Ift57 Psma3 Psmc4 Psmc2 Psma6 Psme1 Psmd1 Psme2 Psmd7 Gpr161 Ift140 Psmd3 Tulp3 Psmd6 APC-CDC20 MEDIATED DEGRADATION OF NEK2A%REACTOME DATABASE ID RELEASE 66%10145263 APC-Cdc20 mediated degradation of Nek2A Anapc7 Cdc26 Cdc27 Cdc23 Ube2c Ube2d1 Bub3 Anapc16 Cdc16 Cdc20 Nek2l1 Anapc4 Anapc2 Anapc1 Bub1b Anapc11 Anapc15 Nek2 Mad2l1 Anapc10 NFG AND PRONGF BINDS TO P75NTR%REACTOME%R-RNO-205017.1 NFG and proNGF binds to p75NTR Ngf Ngfr TRANSCRIPTIONAL ACTIVATION OF CELL CYCLE INHIBITOR P21%REACTOME DATABASE ID RELEASE 66%10146177 Transcriptional activation of cell cycle inhibitor p21 Zfp385a LOC100910954 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS%REACTOME%R-RNO-416993.1 Trafficking of GluR2-containing AMPA receptors Ap2a2 Prkca Prkcb Nsf Ap2s1 Gria3 Gria4 Grip1 Grip2 Ap2a1 Pick1 Ap2m1 PROLINE CATABOLISM%REACTOME DATABASE ID RELEASE 66%10144794 Proline catabolism Prodh Iffo2 Tas1r2 Aldh4a1 DEGRADATION OF GLI1 BY THE PROTEASOME%REACTOME DATABASE ID RELEASE 66%10146077 Degradation of GLI1 by the proteasome Psmc6 Psmb10 Sufu G6pc Psmb8 Psmb9 Psmb4 Psmb11 Psmb5 Psmf1 Psmb6 Psmd4 Psmb2 Rbx1 Cul1 Psmd5 Psmd8 Psmb7 Psmd9 Psmb1 Gli1 Psmb3 Psma8 Skp1 Psmd11 Psmd12 Psmd13 Psmd14 Psma5 Btrc Psma2 Psmc5 Psmc3 Psmd2 Psma1 Psma4 Psmc1 Psma3 Psmc4 Psmc2 Psma6 Psme1 Psmd1 Psme2 Psmd7 Psmd3 Psmd6 BETA OXIDATION OF DECANOYL-COA TO OCTANOYL-COA-COA%REACTOME%R-RNO-77346.1 Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA LOC100911186 Echs1 Hadh Hadha Hadhb Acadm MMR%REACTOME%R-RNO-5358508.1 MMR Msh3 Msh2 Rpa3 LOC100911727 Pold2 Pold1 Pcna Pold4 Rpa1 Rpa2 Pms2 Mlh1 Msh6 Lig1 POST-TRANSCRIPTIONAL SILENCING BY SMALL RNAS%REACTOME DATABASE ID RELEASE 66%10145622 Post-transcriptional silencing by small RNAs Ago3 Ago4 Tnrc6b Ago2 Tnrc6a Tnrc6c PI METABOLISM%REACTOME DATABASE ID RELEASE 66%10145378 PI Metabolism Enpp6 Pten Tpte2 Pitpnb Sbf1 Ptpn13 Inpp4a Inpp4b Mtmr14 Mtmr12 Sacm1l Pip5k1c Pi4k2a Pip5k1b Pip5k1a Fig4 Vac14 Tmem55b Pip4k2b Ocrl Pip4k2c Pik3r5 Bmx Mtmr9 Mtmr6 Pik3r1 Pik3r3 Mtmr7 Pik3r2 Mtmr2 Pik3r6 Synj1 Pi4kb Mtmr4 Plekha4 Plekha3 Plekha5 Inpp5d Inpp5e Plekha8 Synj2 Plekha1 Inpp5f Tnfaip8l3 Pik3cd Tnfaip8l1 Mtmr3 Pik3cg Mtmr1 Inpp5j Tnfaip8 Tnfaip8l2 Rufy1 Pik3c3 Pik3r4 Pik3cb Pnpla6 Pikfyve Pik3c2a Pik3c2b Pik3c2g Pi4k2b NEGATIVE REGULATION OF FGFR4 SIGNALING%REACTOME%R-RNO-5654733.1 Negative regulation of FGFR4 signaling Mknk1 Src Fgf16 Fgf17 Fgf9 Fgf2 Fgf8 Cbl Spry2 Fgfr4 Mapk1 Fgf23 Fgf4 Ptpn11 Fgf1 Ppp2cb Ppp2ca Fgf6 Ppp2r1a Fgf19 Frs2 Fgf20 Grb2 NUCLEOBASE CATABOLISM%REACTOME%R-RNO-8956319.1 Nucleobase catabolism Nt5c1a Nt5c Adprm Nt5c3a Nudt9 Nt5e Nt5c2 Nudt5 Nudt16 Nudt18 Upb1 Nt5m LOC688828 Entpd2 Tymp Entpd6 Entpd3 Entpd4 Entpd1 Entpd7 Entpd5 Entpd8 Xdh Dpys Pnp Upp1 Upp2 Nt5c1b Nudt15 Nudt1 Gda Itpa Samhd1 Dnph1 CROSS-PRESENTATION OF PARTICULATE EXOGENOUS ANTIGENS (PHAGOSOMES)%REACTOME%R-RNO-1236973.1 Cross-presentation of particulate exogenous antigens (phagosomes) LOC685953 Cd36 Ncf1 Ncf4 RGD1565355 Cybb Cyba MEIOSIS%REACTOME%R-RNO-1500620.1 Meiosis Prdm9 AKT-MEDIATED INACTIVATION OF FOXO1A%REACTOME DATABASE ID RELEASE 66%10145436 AKT-mediated inactivation of FOXO1A Akt3 Foxo1 Akt1 Akt2 CREB PHOSPHORYLATION%REACTOME%R-RNO-199920.1 CREB phosphorylation Rps6ka2 Rps6ka1 Rps6ka3 Rps6ka5 Creb1 Atf1 Mapkapk2 RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN INTERLEUKIN SIGNALING%REACTOME DATABASE ID RELEASE 66%10146268 RUNX1 regulates transcription of genes involved in interleukin signaling Elf1 Cbfb Runx1 SDK INTERACTIONS%REACTOME%R-RNO-373756.1 SDK interactions Sdk2 XENOBIOTICS%REACTOME DATABASE ID RELEASE 66%10144919 Xenobiotics Cyp2b2 Cyp2c24 Cyp2s1 Cyp2b1 Cyp2b3 Cyp2d5 LOC100361492 Cyp2j10 LOC100360055 Ahr LOC100910127 Cyp2c13 LOC100361547 Cyp3a23/3a1 Cyp3a73 Cyp2b21 Arnt LOC100911763 Cyp2c7 Cyp2b15 Cyp2e1 Cyp2b12 Cyp2d4 Cyp2f4 Cyp3a18 Cyp1a1 LOC100910877 Cyp2d2 Arnt2 Cyp1a2 Cyp2d3 Cyp2c6v1 SIGNALING PATHWAYS%REACTOME%R-RNO-162582.1 Signaling Pathways Usp7 Yy1 Rbx1 RGD1565904 Polr2g Polr2h Polr2e Polr2f Polr2j Polr2k Polr2d Polr2i Polr2b Polr2c Polr2a LOC100912534 Actb Cdk4 Ccnd1 LOC100911822 Irak4 Ripk2 Dusp3 Dusp4 Traf6 Cul1 Vrk3 Rps6ka2 Rps6ka1 App Rps6ka3 Rps6ka5 LOC100912585 Tab1 Dusp7 Dusp6 Rela Atf1 Atf2 Map3k7 Nfkbia LOC100910771 Parp1 Cdk2 Rbbp5 Hnrnph1 Jun Ppp2cb Ppp2ca Skp1 Ppp2r1a Ncbp2 Nfkb1 Mapk8 Fos Ncbp1 Mapk7 Ybx1 Chuk Ppp2r1b Mapkapk3 Btrc Mapkapk2 Mapk1 Adora3 Creb1 Tab2 Tab3 Adora2a Adora2b Ikbkb Hnrnpm Hnrnpf Mapk14 Myd88 LOC100911796 LOC100363178 Adora1 Mapk11 LOC100365814 Smarca4 Mecom Ash2l Gpr39 Olr663 Olr660 Olr561 Olr1024 Olr560 LOC100910009 Olr158 Olr557 LOC100910335 Olr164 Olr659 Olr160 Olr657 Olr662 Olr664 Olr1868 Olr1199 Gpr27 Olr653 LOC100910402 Olr651 Olr650 Olr294 LOC100911909 Olr544 Olr1197 Olr1196 Olr1195 Olr1194 Olr1198 LOC100910409 Olr1128 LOC100911893 LOC100910928 Olr323 Olr119 Olr1126 LOC100912097 Olr1125 Olr420 Olr217 Olr1121 Olr1122 Olr1129 Olr322 Olr214 Olr215 Olr414 Kng1l1 Olr1512 Olr1513 Olr416 Olr556 Gpr150 Olr1511 Olr413 Olr1517 Olr319 Olr120 Olr321 Olr1514 LOC100911380 Olr417 Olr418 LOC100910041 Olr259 Olr1163 Tmed2 Olr1166 LOC684208 Olr127 Olr530 Olr126 Olr931 Olr674 Olr129 Olr532 Olr1174 Olr670 Gpr45 Olr675 Olr892 Olr247 Olr1156 Olr190 Olr194 Olr267 LOC500460 Olr192 Olr262 Olr1064 Olr896 Olr263 LOC100910049 Olr698 Olr799 LOC103693566 Olr922 Olr684 Olr1186 LOC100910120 Olr536 Olr1185 Tln1 Olr143 Crk Olr535 Olr140 Vwf Apbb1ip Olr142 Bcar1 Olr148 LOC100910648 Olr1016 Olr149 Olr951 Gpr25 LOC100910224 Olr666 Traf2 Olr1179 Olr522 Olr130 Olr527 Olr526 LOC100910637 Olr132 LOC100910010 Olr529 Olr528 Olr139 Olr137 Olr686 Olr1877 LOC100910559 Olr186 Olr189 Olr1081 Usp21 Olr1147 Olr188 Olr584 Olr1082 Olr281 Olr382 Olr384 Olr1086 Olr1087 Olr587 Olr581 Olr282 Olr776 Olr582 Olr777 Olr583 Olr283 Il33 Olr962 Gpr15 Olr964 Olr285 Olr286 Olr1135 Olr1132 Olr172 LOC100910051 Olr1130 Olr170 Olr198 Olr588 Olr199 Olr1155 Olr597 Olr1057 Olr196 LOC100911805 Grk6 Olr252 Olr1052 Olr598 Olr695 Olr251 Olr250 Olr697 LOC100910999 Olr590 Grk5 LOC100910445 Olr1143 Olr180 Olr690 Olr1144 Olr783 Olr379 Olr1142 LOC100910162 Olr782 Gpr176 LOC100911839 Olr184 Olr845 LOC100910274 Olr847 Olr848 Olr1391 Gpihbp1 Olr852 Olr1496 LOC686792 LOC100912204 Olr1096 LOC100365798 RGD1562066 Olr844 Olr841 Olr744 Olr745 LOC100909686 Olr878 LOC100910597 Olr1376 Penk Olr850 Olr851 LOC100909578 LOC100909683 LOC100910294 Kng1 LOC687097 LOC100909884 LOC100909885 Foxo4 Olr1374 Olr1372 Olr1373 Olr1370 Kng2 Olr1071 Olr569 Olr174 Olr175 Olr774 Olr176 Htr4 Olr1274 Olr1076 LOC100910876 Olr575 Olr1075 Olr373 Olr1275 Olr1070 Olr1137 Htr7 Olr375 Olr377 Olr378 Olr372 Olr1079 Olr374 Olr1073 Olr854 Olr853 Olr279 LOC100911035 Olr765 Olr278 Olr376 Htr6 Npff LOC100910256 LOC100912571 Npffr2 Olr834 Olr641 LOC100909438 RGD1560028 LOC100909796 Hcrt Npffr1 Gpr83 Eif4ebp1 Qrfp LOC690821 LOC100909783 LOC100912217 Olr601 Olr602 Olr604 Olr709 Olr609 Olr607 Olr608 LOC687088 Olfr873 Olr806 LOC686677 Olr702 Olr808 Olr705 Olr704 Olr807 Olr519 Olr614 Olr718 Eif4g1 Olr811 Olr514 Olr515 Olr611 Olr610 Rictor Olr819 Olr716 Olr713 Olr816 Olr717 Olr714 Olr813 Olr812 Olr1382 Olr1381 Olr1384 Olr1383 Olr711 LOC100911372 Hif1a LOC100912327 Olr818 Olr712 Olr724 Olr1380 Reep6 LOC684683 Rps6 Olr720 Olr722 LOC686660 Olr1385 Olr1378 Hcrtr1 Reep1 Qrfpr Reep5 Olr729 Hcrtr2 Reep4 Reep3 LOC680559 Reep2 Olr725 Src Wnt5b Wnt5a Prickle1 Fzd1 Cltc Cltb Fzd3 Clta Fzd2 Fzd4 Ywhah Fzd7 Ywhag Fzd6 Sfn Prkcb Ywhaz Ap2s1 Wnt1 Ppp3r1 Otulin Wnt11 Wnt4 Ywhab Ap2a1 Ywhaq Ror1 Ywhae Ror2 Ap2m1 Bad Smpd2 Smpd3 Usp4 LOC687065 Drd5 Drd1 LOC684539 Olr820 Olr821 Olr823 Med1 Mgll Abhd12 Daglb Abhd6 Dagla Cited1 Nr5a2 Gtf2f1 Gtf2f2 Kdm4b Carm1 Greb1 Usf1 Gtf2a1 Foxa1 Bmyc Thbs2 Ptges3 Prmt1 Zfp217 Ptges3l1 Esr1 Pou2f1 Cbfb Tle3 Gata3 Fkbp4 Ddx5 Erbb4 Crebbp Nrip1 Pgr Ncoa1 Tbp Runx1 Kras Grb7 Pik3r1 Il6 Pik3r2 Dll4 LOC100911431 Eif4b Usp2 Adra2a Gnai2 Adra2c Cdk1 Mapkap1 Pik3cb Tek Ptpn11 Notch2 Mdk Angpt1 Hras Nras Gnai1 Sos1 Shc1 Grb2 Ptpn18 Ereg Rnf41 Nrg1 Btc LOC102552659 Erbb3 Erbb2 Nrg3 Matk Egfr Jag1 Hbegf Notch3 Ghrl Nrg4 Tnf Rnf31 Atp6v1g1 Sharpin Atp6v1g2 Traf1 Atp6v0a4 Rbck1 Atp6v1b2 Atp6v0a2 Atp6v1h Atp6v1f Il1rap Ptpn12 Usp8 Nrg2 Pnlip Pik3ap1 Il1rl1 F11r Atp6v0d1 Atp6v1c2 Atp6v0d2 Phlpp1 Ier3 Pdgfa Pdgfb Rps6kb2 Foxo1 Foxo3 Atp6v1a Atp6v0e2 Atp6v0e1 Clps Cma1 Atp6v1g3 Atp6v1e1 Atp6v1e2 Cdh1 Atp6v1c1 A2m Kdr Itga3 Abca4 Lama4 Plg Prkca Lyn Crkl Yes1 Lama1 Rapgef1 Galnt3 Syk LOC100911248 Oprl1 Grin2d Ccl21 Camk2g Prokr2 Grin2b Grin1 Mc3r Ccr5 Gal Ccr4 Nefl Rasgrf1 Mmp9 Ccr3 Gpr37 Dlg1 Ccl27 Dlg2 Cckar Frs3 Gper1 Ccl20 Dlg3 Uts2r Camk2d Prokr1 Actn2 Ccl25 Camk2a NMS Xcr1 Cxcl16 Pdyn Lamc1 Prlhr Lamc2 Ccr10 Gpr37l1 Ccl19 Ccr7 Ccr8 Cxcr3 Cxcl10 Ccr9 Cxcl11 Ece2 Ece1 Xk Sstr5 Brs3 Npbwr1 Pyy Col9a1 Pnoc Col9a2 Ccl5 Npy2r Col9a3 Prkcq Mc4r Col4a1 Prok2 Oprm1 Fgb Prok1 Ret Sstr1 Fgg Mchr1 Aplnr Sstr4 Sstr2 Cck Npy1r Thbs1 Apln Tacr3 Col4a2 Fes Tacr2 Bdkrb1 Fga Gdnf Bdkrb2 Rln3 Lamb1 Npb Ppy Trh Ccl1 Lamb2 Npw Map2k2 Lamb3 Mc2r Pspn Npy Nps Spp1 Pde3a Sstr3 Spta1 Gfra4 Gfra3 Gfra2 Dok1 Pde2a Cyct Pde10a Pde11a Gphb5 Artn Fn1 Gnrhr Gpha2 Shc3 P4hb Gnrh1 Nrtn Ptpra Fshr Tshr Lrrk2 Ncam1 Sptbn1 Khdrbs2 Gpnmb Khdrbs1 Khdrbs3 Cxcr5 Uts2b Npy5r Nmur2 Cxcr6 Oprd1 Itga2b Lhcgr LOC100909513 LOC100360745 Pten Adam17 Aph1b Psenen Aph1a Ngfr LOC100911293 Psen2 Psen1 Ncstn Lhb Furin Awat2 Cpt1b Cpt1a Fgf2 Ttr Bmp2 Tgfb1 RGD1564865 Cga Pik3r5 Uts2 Ntsr2 Trhr Nmu Pf4 Mc5r Pik3r3 Ntsr1 Pmch Pik3r6 Rxfp1 Rxfp2 Kel Insl3 Tac3 Kiss1 Rxfp3 Tac1 Edn2 Ednra Ednrb Edn3 Grpr Cx3cr1 Edn1 F2rl1 Sst Ackr4 Ackr3 Nmb Xcl1 Cxcl9 Cxcl6 Cx3cl1 Agtr2 Prlh Galr1 Ccrl2 Nts Oprk1 Cd80 Cd86 Pla2g4a Gabbr1 Gabbr2 Il6st Cyp26c1 Cxcl12 Myo9b Cxcr4 Arhgdia Rtn4 Cyp26a1 Adh6 Lingo1 Omg Mag Cyp4v3 Cyp26b1 Csnk2a2 Csnk2a1 Stra6 Rdh10 Wnt9b Rdh16 Wnt9a LOC100365958 Vps26a Wls LOC100362350 Akr1c12l1 Cmklr1 Gpr35 Akr1c19 Wnt7a Wnt2b Wnt7b Akr1c13 Vps29 Akr1c14 Wnt16 Vps35 Akr1c12 Wnt10a Wnt6 Pomc Tax1bp1 Sppl2a Clip3 Rpe65 Pik3cd Dhrs9 Nup85 Pik3cg Myo7a Sdr9c7 Hsd17b6 Gpc6 Gpc4 Gpc2 Gpc1 Opn1sw Dhrs3 Rlbp1 Nup98 Nup107 Akr1b7 Akr1b8 Ppard Opn1mw Pip5k1c Pip5k1b Pip5k1a Akr1c2 Akr1c3 Ocrl Akr1c1 Cdc14b Agrn Mapk4 Cdc42ep5 Cdc42ep3 Etv4 Cdc42ep2 G6pc Mapk6 Atp6ap1 Nup43 Nup133 Nup37 Sdc2 Sdc3 Sdc4 Adra2b Adrb3 Ranbp2 Lpar5 S1pr1 S1pr5 S1pr4 S1pr3 Lpar1 Lpar3 Lpar2 S1pr2 Lppr1 Lppr4 Lppr5 Lppr2 Lppr3 Ctbp2 Sav1 Amot Ptpru Cab39l Grap Fer Stk4 Stk3 Mob1b Mob1a Wwc1 Eef2k Elf3 Lats1 Strada Stradb Amotl2 Rps6kb1 Fstl1 Grem2 Fstl3 Amhr2 Cer1 Nog Foxh1 Acvrl1 Amh Acvr2a Chrdl1 Smad9 Smad5 Smad6 Acvr1c Gdf2 Bmpr2 Acvr1b Fst Zfyve16 Inhba Drap1 Birc3 Birc2 Cyld Notch4 Casp2 Casp8 Casp9 Cckbr Gast Ngfrap1 Plcb1 Racgap1 Plcb3 Ffar1 Rarg Gnaq Esr2 Gna11 Gna14 Gna15 Nr4a1 Inpp5b Plcb4 Lrp5 Lrp6 Wnt3 Rnf43 Mapkapk5 Rara Rarb Yap1 Rspo1 Lgr4 Lgr6 Lgr5 Rspo4 Wnt3a Rspo2 Rspo3 Gnai3 Dock7 Akt1 Ranbp9 Ntf4 Gnao1 Ntrk2 Bdnf Chrm4 Gnat2 Gnaz Rxrg Ntrk3 Ntf3 Rhob Dlg4 Rhoc Dtx4 Prc1 Cit Cyfip1 Arf6 Spint1 Gga3 Gdi2 Hgf Ptpn2 Stam2 Sh3gl2 Sh3gl1 Spint2 Sh3kbp1 Muc20 Hgfac Nckap1l Sh3gl3 Ranbp10 Tns4 Lrig1 Stam Rab4a Rock1 Frk Psmb7 Psmb1 Lrrc7 C5ar1 LOC687609 Dsn1 Cab39 Atp6v0a1 Psma5 Rap1a Psma2 Psmd2 Ptpn6 Psmc2 Psmd1 Psmd7 Iqgap1 Psmd3 Psmd6 Ptpn1 Tshb Dnajb1 Gnal Akt1s1 Gnat3 Prkci Grp Ffar4 Xiap Tnks Phc1 Phc2 Stat5a Jak3 Stat1 Jak1 Madd Stat3 Rxra Hist1h2bo Sall4 Hist1h2bcl1 Scmh1 Hist2h3c2 Cbx4 Hist1h2bk Cbx2 H3f3b Cbx8 Cbx6 Bmi1 Hdac2 Rnf2 Mbd3 Usp13 Ring1 Chd3 Chd4 Phc3 Prex2 Mta3 Tnks2 Mta1 Mta2 Tyk2 Gatad2a LOC100910717 Maf1 Gatad2b Eed LOC100910200 H2afx Hist1h4b LOC684841 Hist1h2bh LOC100912290 Rbbp7 Hist1h2ail1 Hist1h4m LOC102549173 LOC103690002 LOC100910152 LOC100912338 Hist1h3c H2afb3 Hist1h3f Hist2h4 LOC684819 Hist1h3a H2afj Hist2h2aa3 Hist1h2bq Hist2h2aa2 LOC100364835 LOC684762 Lrp1 RGD1560225 Ppp3ca Tec Lat Plcg1 Hist1h2bg Ezh2 LOC680097 LOC684797 LOC100912418 Hist1h2ba Hist3h2bb Cnga1 Gucy2f Pde6b Rcvrn Gucy2d Pde6a Rgs9 RGD1560341 Gpr84 Guca1b Ppef1 Metap2 Metap1 Gnat1 Nmt1 Guca1a Cngb1 Rgs9bp Fnta Nmt2 Sag Grk4 Grk1 Fntb Pde6g Cdc14a Cdkn1a Cdkn1b Vegfa Rasa1 Shb Fkbp5 Pdhb Pdk3 Pdk4 Pdk1 Pdk2 LOC100365902 Pdha2 Pdha1 Pdhx Pdha1l1 Dlat Dld Atp6v1d Psap Rac1 Psmd11 Psmd12 Fabp5 Oxgr1 Psmd13 Psmd14 Ccr1 Ccr1l1 Ptgdr2 Sucnr1 Ap2a2 Psmc3 Diaph1 Cxcr2 Atp6v0c Hsp90ab1 Ptafr Rab4b Gpr31 Cxcl2 Cxcl1 Rgr Gpr18 Bag4 Gpr55 Gpsm3 Htr5a Cxcl3 Gpsm2 Gpsm1 Cnr2 Ccl4 Opn3 Cnr1 Htr1d Htr1f Htr1a Htr1b Hrh4 Ptger3 Gpr183 Mtnr1a Opn5 Pcp2 Hcar1 Hcar2 Sh2b2 Drd4 Drd2 Fpr1 Apc Otud3 Otud7b Vcl Sptan1 Vcp Dkk1 Kremen2 Sost Chd8 Ripk1 Lamtor3 Tnfaip3 Dync1h1 Lamtor2 Lamtor1 Dync1li1 LOC103692716 Cybb Cyba Hmha1 C3ar1 Prkcd Notch1 Peg12 Amer1 Dtx2 Frat2 Tcirg1 Ptprj Jup Cd28 Icos Bcl2l11 Tjp2 Dtx1 Sox2 Hecw1 Dact1 Csnk2b Actr2 Wnt8a Sox7 Sox6 Sry Sox17 Rbp4 Arhgap9 Ctnnbip1 Ryk Wnt8b C3 Lrp10 Dkk2 Dkk4 Rbp2 Cby1 Ppbp Tex12 Sox13 Rbp1 Lrp8 Apom Lrp12 Lpl Rhoa Bco1 Rdh11 Arpc5 Lrat Pcsk6 Bco2 Rhof Rhog Pcsk5 Olr1442 Olr1443 Nsmaf Trim27 Olr1548 Olr80 Mdm2 Olr1440 Olr1547 Ppp1ca Pde4a Crabp1 Pde4d Pde4c Ppp1r1b Cdk5 Sdr16c5 Socs3 Nos3 Leo1 Dhrs4 Rdh14 Rdh13 Aldh8a1 Epor Pml Epo Olr1436 Ptgir Olr1569 Olr1567 Olr1421 Fyn Olr1568 Olr1565 Stat6 Olr1566 Olr1538 LOC100912374 Olr1539 Olr1437 Olr1439 Olr1433 Olr1434 Olr1435 LOC103690304 Olr83 LOC100912370 Olr1533 Olr1432 Olr1535 Olr1537 Olr1536 Olr81 Olr1449 Olr1542 Olr1541 Olr1540 Olr1445 Sox9 Nck2 LOC103693022 LOC100912463 Smad3 Ccnt2 Smad2 Pard6a Nedd8 Fkbp1a Strap Usp9x Sp1 Ube2d1 Skil Rbl1 Ncor2 Cdk9 Mtmr4 E2f4 Zfyve9 Hdac1 Tgif2 Tgif1 Atp1b4 Trim33 Pmepa1 Ccnk Ube2d3 Pard3 Bambi Wwtr1 Tfdp1 Prkcz Tfdp2 Stub1 Tas2r144 Grm3 Casr Grm1 Grm6 Tas2r113 Grm2 Grm8 Srms Tas2r114 Tas2r110 Ptk6 Gprc6a Wwp1 Tas2r124 Tas2r125 Tas2r126 Tas2r121 Tas2r103 Tas2r104 Tas2r123 Tas2r116 Tas2r140 Tas2r120 Tas2r102 Tas2r145 Tas2r119 Tas2r118 Tas2r117 Pde1b Tas2r107 Tas2r108 Tas2r105 Tas2r106 Tas2r129 Tas2r109 Tas2r136 Tas2r137 Tas1r1 Tas2r135 Tas2r13 Tas2r130 Tas1r3 Tas2r139 Apob Apoc2 Apoe Apoa2 Gng10 Arhgef6 Arhgef5 Arhgef39 Arhgef7 Arhgef37 Arhgef38 Il2rg Pdgfra Arhgef33 Pdgfrb Prex1 Adra1a Tbxa2r Itsn1 Arhgef2 LOC102556447 Arhgef4 Arhgef3 Plekhg5 Arhgef19 Arhgef18 Plekhg2 Kalrn Adra1d Plxnb1 LOC100912512 Gna12 Vav2 Gna13 Flrt1 Vav1 Arhgef11 Flrt2 Akap13 Arhgef16 Arhgef15 Pbp2 Net1 Dusp9 Ect2 Dusp2 Arhgef26 Dusp5 Fgd2 Mcf2l Rasal3 Tiam1 Csk Tiam2 Rasal1 Rasal2 Vav3 Rasgrp1 Pebp1 Rasgrp4 Rasgrp3 Pea15 Fgd3 Dusp1 Sos2 Ngef Mark3 Araf Rasa4 Il5 Spred1 Spred2 Rasgef1a Il2 Rasa2 Rasa3 Trpc3 Il2ra Trpc7 Csf2 Il3ra Nf1 Kit Trpc6 Syngap1 Kitlg Il2rb Olr1600 Dusp16 Olr1605 Map3k11 Csf2ra Olr1405 Olr1601 Csf2rb Ksr1 Olr1407 Rapgef2 Olr1404 Wdr83 Olr1406 Ksr2 LOC100910837 Olr1368 Raf1 Olr1369 Ppp5c Olr226 Il17rd LOC100911348 Il5ra Cnksr1 Olr229 Cnksr2 Olr227 Olr1602 Dusp10 LOC684170 Paqr3 LOC103692138 Olr1504 Olr233 Olr428 Olr232 Olr427 Olr1505 Olr234 LOC100911377 Olr1400 LOC100911376 Ccne1 Olr231 RragB Ptgdr Prkab1 Olr425 Nphp4 Prkab2 Olr1501 Olr230 Disp2 Olr208 Adcy8 Olr1202 Olr244 Rpgrip1l Adcy9 LOC103693685 Adcy5 Olr1519 Adcy4 Olr203 Adcy7 Olr411 Adcy6 Olr209 Prkar1b Rasgrp2 Olr1007 Prkar1a Olr1006 LOC100911223 Stap2 Smo Olr237 Wdr35 Olr434 Olr1306 Evc2 Olr442 Kif3a Ift88 Olr441 Dnal4 Olr113 Olr210 Ralgds Olr1520 Kidins220 Olr114 Olr1523 Olr218 Olr1522 Olr1521 Olr206 F2rl3 F2r Olr1118 Olr204 F2 Olr205 LOC100911398 Ptger2 Pip4k2b Pip4k2c Olr1115 Olr1117 F2rl2 Pde7a Hebp1 Olr1734 Fpr-rs6 Olr1340 Olr485 Olr486 Fpr-rs3 Olr16 Fpr2 Olr1735 Fpr3 Anxa1 LOC100911043 Olr1737 Olr14 Olr1736 Olr488 Fpr-rs4 Olr484 Pde7b Olr1730 LOC100912515 Olr1627 Olr491 Olr1626 Olr490 Olr1621 LOC100912408 Olr1625 Olr1624 Olr200 Olr339 Olr1345 Olr338 Olr1343 Olr202 Olr1344 Olr1341 Olr1356 Mtor Taar9 LOC100912605 Rheb LOC100911849 Hrh2 Prkag3 LOC100910199 Rptor Fshb Taar6 Agt Lamtor4 Olr346 Taar5 Tsc1 Taar2 Lamtor5 Olr1214 Olr450 Mlst8 Prkaa1 Olr499 Olr496 Tsc2 Rraga LOC100912505 Prkaa2 Olr493 Olr1606 Rragc Olr1607 Akt3 Olr1749 Rragd Olr1608 Slc38a9 Olr1362 Olr459 Olr458 Olr1361 Olr1366 Olr1364 Olr360 Olr462 Olr1611 Olr1610 Olr1358 Olr1612 Olr20 Olr24 Olr23 Olr1456 LOC100912431 Olr1597 Olr1593 Olr1592 Olr1450 Olr1452 Olr1598 Olr1454 LOC100909966 LOC100365887 LOC100912159 Olr1654 LOC103693822 Olr30 Olr32 Olr34 Olr331 Olr332 Olr1643 Olr334 Olr330 Olr1642 Olr1644 Olr1645 Olr473 Olr470 Olr1744 Olr1641 Olr1743 Olr1746 Olr472 Olr1640 Pde8b Smurf1 Olr477 Olr475 Pde8a Tgfbr1 LOC100911479 Olr1235 Ube2m Olr1738 E2f5 LOC103690286 Cbl Olr1231 Hdac1l Olr329 Snw1 Tgfbr2 Or7e24 Cgn LOC103690280 Olr326 Olr325 Olr1339 Olr1639 Olr13 Olr12 Olr1637 Olr1638 Olr340 Olr341 LOC102555599 Olr1635 Olr1630 Olr1631 Olr1632 Olr1633 Olr1423 Mks1 Ccnd3 Cdc73 Olr1560 Olr63 Csnk1a1 LOC100912684 RGD1564313 Dzip1 Olr1424 Sufu Olr1564 Dhh Olr1425 Cdon Olr1422 Shh Olr1558 Ptch1 Olr1559 LOC684179 Efcab7 Spop Olr1555 Ptgdrl Iqce Olr67 Tert Spopl Olr68 Ofd1 Olr69 Ulk3 Olr1416 Boc Olr70 Gli1 Olr1418 Gli3 Olr1417 Gli2 Adcy3 Olr1551 Prkar2b Olr1557 Prkar2a Olr1553 Ihh LOC686967 Olr77 Ift122 LOC100909611 Os9 Olr1693 Evc Rtp4 RGD1559714 Wdr19 Olr74 Ttc21b RGD1562400 Olr78 RGD1563667 Olr75 Erlec1 Olr1583 Olr1589 Olr1488 LOC100912420 Olr1582 LOC100909993 Rtp3 Rtp2 Olr1475 Olr1470 LOC687110 Olr1576 Olr49 Olr46 Olr1588 Olr48 Olr1467 Pygo2 Arrb1 Olr1468 Ift52 Olr1469 Kif7 Olr50 Arrb2 Olr51 Ift57 Olr59 Gas1 Csnk1e Hhip Olr1671 Gas8 Olr1471 Olr1667 LOC689173 Tcf7 Olr29 Lef1 LOC100909831 Adrbk1 Tcf7l1 Olr27 Gpr161 Bcl9l Olr25 Scube2 Tle4 Olr1462 Ift140 Tle1 Sel1l Tle2 LOC100912540 LOC100911586 Tulp3 Pygo1 Faslg Cenpn Zwilch Cenpl Cflar Fadd Cenpo Klc1 Dync1li2 Cilp Cenpt Cenpu Maml1 Abi1 Bub3 Rbpj Nlk Bub1 Kat2a Abi2 Potef Spdl1 Kntc1 Rbpjl2 Dync1i2 Mad1l1 Rtkn Myh9 Nck1 Casp3 Cenpk Cenph Cenpi Rock2 Klc4 Cenpf Kdm1a Cenpe Cenpm Tradd Tnfsf10 Klc2 Ahctf1 Fas Klc3 Ndel1 Mknk1 Rcc2 Esrp2 Noxo1 Esrp1 Arpc1b Rbfox2 LOC100909750 Pafah1b1 Fgfrl1 Rhpn1 Tia1 Tial1 Ncf1 Fgfbp3 Ncf4 Rhpn2 Fgfbp1 Ppp1r12a Spry2 LOC100361515 Mis12 Dynll2 Ndc80 Cenpc Sqstm1 Noxa1 Pdgfc Ppp1r14a Pdgfd Thbs4 Cenpa Dync1i1 Plat Daam1 Srgap2 LOC100909840 Ptk2 Actg1 Cyfip2 Birc5 Nckap1 Taok1 Sh2d2a Hspb1 Flt4 Ccr6 LOC100911280 LOC100909609 Flt1 Ptk2b Pxn Figf Shc2 Vegfc Nrp1 Nrp2 Vegfb Axl Pgf Ntrk1 Ngf Apoa1 Oxtr Oxt LOC100909648 Avpr1b Avpr1a Dock1 Ctnnd1 Cdh5 Elmo2 Myh14 Myh11 Cdca8 Ghrh Ramp3 Flna Pkn1 Vipr2 Sct Evl C5ar2 Tax1bp3 Gip Pkn2 Gipr Pth1r Pkn3 Ptpn3 Brk1 Iapp Cdc25c Crhr2 Gcgr Rangap1 Adgre1 Cd19 Fmnl1 Crhr1 Ppp1cb Glp2r Baiap2 Pth2 Ppp1cc Ramp2 LOC100909468 Ghrhr Aurkb Limk1 Sec13 Nf2 Xpo1 Pak2 Pak3 Pak1 Rac2 Ptprk Wasl LOC100911204 Spry1 Spc24 Spc25 Nox3 Nox1 Abl1 Itgb3bp Sgol2 Rhod Wasf1 Arpc4 Ppp2r5e Incenp Rhoq Ktn1 Arpc3 Nsl1 LOC102551071 B9d2 Cdc20 Kif2a Kif2c Kif2b Men1 Bub1b Kif18a Ppp2r5c Ppp2r5a Nckipsd LOC100361457 Ppp2r5b Zwint Mylk Kif5b Mad2l1 Kif5a Casc5 Actr3 Lin7b Was Clasp2 Ercc6l Ctnna1 Nuf2 Mapk13 Pik3c3 Mapk12 Ncoa2 Dscam Clasp1 LOC679582 Iqgap3 Dvl1 Mkl1 Pik3r4 Pdpk1 Mapre1 Cdc42 LOC100911597 Pmf1 Dvl2 Dvl3 Pfn1 Pfn2 Ckap5 Scai Ska2 Wipf1 Wipf2 Wipf3 Sgol1 Zw10 Srf Ska1 Arhgap18 Arhgap19 Psmc6 Arhgap21 Arhgap17 Psmb10 Myo9a Arhgap22 Arhgap10 Psmb8 Arhgap20 Psmb9 Srgap1 Psmb4 Srgap3 Psmb11 Arhgap39 Psmb5 Rhobtb2 Psmf1 Arhgap36 Psmb6 Psmd4 Depdc1b Arhgap44 Psmb2 Arhgap35 Psmd5 Arhgap5 Psmd8 Arhgap6 Psmd9 Arhgdib Psmb3 Rhoj Ralbp1 Psma8 Rhoh Depdc7 Arhgap11a Dlc1 Syde1 Syde2 Fam13a Fam13b Gmip Arhgap15 Arhgap12 Arap1 Stard13 Tagap Chn2 Stard8 Ophn1 Arhgap1 Arhgap8 Rhot2 Rhot1 Pth Sctr Adm Crhbp Calcb Vip Calca Ramp1 Htr2c Htr2a Adcyap1r1 Ucn Dgkk Dgki Adcyap1 Ucn2 Pth2r Adm2 Crh Htr2b Ccl9 Ccl6 Dgkg Gpr4 Dgkd Dgke Dgka Dgkb Gnb3 Gpr132 Gnb5 Gpr143 Rgs3 Opn4 Gnb2 Gnb1 Rgs19 Gng13 Rgs2 Gng12 Rgs18 Gng11 Hrh1 Arhgap26 Chrm1 Prkaca Arhgap25 Chrm5 Prkacb Arhgap29 Itpr1 Ghsr Arhgap23 Arhgef25 Arhgap28 Dgkz Rapgef4 Arhgap27 Itpr3 LOC100909523 Arhgap42 Dgkq LOC100912034 Arhgap40 Dgkh Gnb4 Glp1r Cysltr2 Camk4 Gcg Cysltr1 Gpr65 Gng4 Gpr68 Gngt2 Arhgap32 Ptgfr Gng5 Gngt1 Prkch Arhgap30 Ptger1 Gng8 Arhgap31 Chrm3 Gng3 Agtr1b Agtr1a Eps15l1 Fgf23 Memo1 Fgf22 Fgf4 Fgf1 Fgf3 Chrm2 Tlr9 Fgf6 Fgf5 Ltb4r Ffar2 Ffar3 Ltb4r2 Avp Ppid Fgf20 Ppidl1 Gab1 Pde3b Igf2 Igf1 Fgf16 Fgf17 Irs2 Fgf10 Fgf9 Fgfr2 Fgf7 Fgf8 Fgfr3 Trib3 Fgfr1 Fgfr4 Grb10 Insr Ins1 Ins2 Fgf19 Them4 Irs1 Frs2 Akt2 P2ry6 Lpar6 P2ry4 P2ry1 Gpr17 Lpar4 P2ry12 P2ry2 P2ry10 P2ry13 Psmc5 Psma1 Psma4 Psmc1 Psma3 Psmc4 Psma6 Psme1 Psme2 Adrb2 Tacr1 TRAF6 MEDIATED IRF7 ACTIVATION%REACTOME DATABASE ID RELEASE 66%10145758 TRAF6 mediated IRF7 activation Irf3 Crebbp Myd88 Dhx36 NEUROTRANSMITTER RECEPTORS AND POSTSYNAPTIC SIGNAL TRANSMISSION%REACTOME%R-RNO-112314.1 Neurotransmitter receptors and postsynaptic signal transmission Plcb1 Mdm2 Raf1 Plcb3 Ap2a2 Adcy8 Adcy9 Adcy5 Adcy4 Adcy7 Adcy6 Gabrr1 Gabrr3 Gabrr2 Gnai3 Gnal Gnat3 Prkcb Nsf Ap2s1 Ap2a1 Myo6 Ap2m1 Camkk1 Gnb3 Kcnj16 Gnb5 Gnb2 Gnb1 Gng13 Chrne Gng12 Chrnd Mapk1 Gng11 Cacng8 Creb1 LOC100912034 Prkca Gnb4 Cacng2 Cacng3 Camk4 Gng4 Cacng4 Gngt2 Gng5 Gngt1 Gng8 Dlg4 Gng3 Grin2d Camk2g Grin2b Grin1 Chrnb4 Nefl Rasgrf1 Dlg1 Dlg2 Glra4 Htr3b Dlg3 Htr3a Camk2d Actn2 Camk2a Glrb Rps6ka2 Rps6ka1 Rps6ka3 Chrna4 Chrna5 Chrna9 Chrna6 Chrnb2 Chrna7 Chrnb3 Chrna2 Chrna3 Chrna1 Kcnj2 Kcnj3 Kcnj15 Kcnj9 Kcnj5 Gabbr1 Kcnj12 Gabbr2 Gng10 Rras Kcnj4 Kcnj6 Gria3 Gria4 Grip1 Grip2 Pick1 Lrrc7 Adcy3 Akap5 Gabra5 Gabra6 Gabrb1 Gabrg2 Gabra1 Gabra2 Gnai2 Grik1 Grik3 Grik2 Ncald Grik5 Pdpk1 Rps6ka6 Hras Gnai1 Gabra4 Gabrb2 PLASMALOGEN BIOSYNTHESIS%REACTOME%R-RNO-75896.1 Plasmalogen biosynthesis Gnpat Agps TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING%REACTOME%R-RNO-975110.1 TRAF6 mediated IRF7 activation in TLR7 8 or 9 signaling LOC100362142 Tlr7 Tlr8 Tlr9 Irak4 Ube2n LOC100912618 Ube2v1 Myd88 Traf6 Dhx36 ABACAVIR TRANSMEMBRANE TRANSPORT%REACTOME%R-RNO-2161517.1 Abacavir transmembrane transport Slc22a1 Slc22a2 Slc22a3 RNA POLYMERASE I PROMOTER CLEARANCE%REACTOME%R-RNO-73854.1 RNA Polymerase I Promoter Clearance Gtf2h1 Gtf2h2 Mnat1 RGD1565904 Ubtf Polr1b Taf1d Taf1c Polr2h Cd3eap Polr2e Znrd1 Polr2f Polr1c Polr2k Polr1a Ttf1 Hist1h2bo Hist1h2bcl1 Hist2h3c2 LOC100912534 Rrn3 Hist1h2bk H3f3b Hdac2 Mbd3 Hdac1l Chd3 Chd4 Ccnh Mta3 Gtf2h3 Mta1 Mta2 Gatad2a Gtf2h5 Tbp Gtf2h4 Gatad2b LOC100910200 H2afx Hist1h4b LOC684841 Hist1h2bh LOC100912290 Rbbp7 Hist1h2ail1 Hist1h4m LOC102549173 LOC103690002 Ehmt2 LOC100910152 LOC100912338 Hist1h3c Hdac1 Ercc3 H2afb3 Hist1h3f Ercc6 Hist2h4 LOC684819 Hist1h3a H2afj Hist2h2aa3 Hist1h2bq Hist2h2aa2 Ercc2 LOC100364835 LOC684762 Cdk7 Twistnb Polr1e Hist1h2bg Mbd2 LOC680097 LOC684797 LOC100912418 Hist1h2ba Hist3h2bb LOC100910121 FCERI MEDIATED NF-KB ACTIVATION%REACTOME%R-RNO-2871837.1 FCERI mediated NF-kB activation Psmc6 Psmb10 Psmb8 Psmb9 Psmb4 Psmb11 Psmb5 Psmf1 Psmb6 Psmd4 Traf6 Psmb2 Cul1 Psmd5 Psmd8 Psmd9 Psmb3 Psma8 Psmd11 Cdc34 Psmd12 Tab1 Psmd13 Rela Psmd14 Map3k7 Prkcq Psmc3 Nfkbia LOC100910771 Ube2n Bcl10 G6pc Ube2d1 Psmb7 Psmb1 Skp1 Nfkb1 Psma5 Fbxw11 Chuk Btrc Pdpk1 Psma2 Psmc5 Psmd2 LOC100362142 Psma1 Psma4 Psmc1 Psma3 Psmc4 Psmc2 Tab2 Psma6 Tab3 Psme1 Lyn LOC100912618 Psmd1 Psme2 Ube2v1 Psmd7 Ikbkb Psmd3 Psmd6 THE AIM2 INFLAMMASOME%REACTOME%R-RNO-844615.1 The AIM2 inflammasome Aim2 FORMATION OF RNA POL II ELONGATION COMPLEX%REACTOME%R-RNO-112382.1 Formation of RNA Pol II elongation complex Gtf2h1 Gtf2h2 Mnat1 RGD1565904 Leo1 Polr2g Polr2h Polr2e Polr2f Supt16h Polr2j Polr2k Polr2d Ctr9 Polr2i Polr2b Polr2c Polr2a Wdr61 Gtf2f1 LOC100912534 Gtf2f2 Ell Tceb2 Tceb1 Iws1 Tcea1 Ccnh Gtf2h3 Paf1 Gtf2h5 Gtf2h4 Cdc73 Aff4 Ccnt2 Tceb3 Rtf1 Cdk9 Supt6h Eaf1 Eaf2 Ercc3 Ccnk Supt5h LOC100911822 Mllt1 Ercc2 Ncbp2 Ncbp1 Supt4h1 Cdk7 Nelfe Nelfa Nelfb Ssrp1 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%R-RNO-427413.1 NoRC negatively regulates rRNA expression LOC100910200 H2afx Hist1h4b LOC684841 Hist1h2bh LOC100912290 Hist1h2ail1 Hist1h4m LOC102549173 LOC103690002 LOC100910152 LOC100912338 Hist1h3c H2afb3 Hist1h3f Hist2h4 LOC684819 Hist1h3a H2afj Hist2h2aa3 Hist1h2bq Hist2h2aa2 LOC100364835 LOC684762 Hist1h2bo Hist1h2bcl1 Hist2h3c2 Hist1h2bk H3f3b Hist1h2bg Mbd2 LOC680097 LOC684797 LOC100912418 Hist1h2ba Hist3h2bb FGFR3C LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 66%10145291 FGFR3c ligand binding and activation Fgf23 Fgf4 Fgf1 Fgf16 Fgf17 Fgf5 Fgf9 Fgf2 Fgf8 Fgfr3 Fgf20 Galnt3 FATTY ACID METABOLISM%REACTOME%R-RNO-8978868.1 Fatty acid metabolism Ndufab1 Cyp1b1 Ptgds Tecr LOC683884 Echs1 Nudt7 Abcd1 Dpep3 LOC100365676 Dpep1 Acly Hsd17b3 Hsd17b8 Acot6 Acot4 Acsbg1 Acot8 Acox1 Ehhadh Eci3 Hsd17b4 Mlycd Acoxl Prkab2 Acsbg2 Slc22a5 Awat1 Alox5ap Cpt1b Eci1 Cpt1a Akr1c12l1 Mid1ip1 LOC100910957 Mcat Hpgds Akr1c19 Acot11 Slc25a17 Thrsp Cyp4f17 Akr1c13 Acot13 Akr1c14 RGD1564865 LOC681458 Slc25a20 Akr1c12 Cyp4f18 Fasn Amacr Tbxas1 Cyp4f39 Tecrl Mut Pon3 Ptges2 Ppt1 Pon1 Ppt2 Pon2 Alox5 Acadvl Lta4h Acsl3 Acsl1 Acsl6 Acsl5 Acsl4 LOC100361547 Acox3 Gpx4 Acox2 Aldh3a2 Slc27a2 Acaa2 Cyp2u1 Cyp4f6 Mapkapk2 Prkaa2 Cyp2c7 Alox12 Alox15b Cbr1 Ltc4s LOC100912391 Acbd7 Cpt2 Acad10 Acad11 Mcee Cyp1a1 Ptgs1 Acbd5 Hacl1 Ptgs2 Acbd6 Ephx2 Cyp1a2 Alox15 Mmaa Acbd4 Cyp2c6v1 Cyp4a2 Cyp4a1 Phyh Ptgis Rxra Aloxe3 Cyp4a8 LOC688708 LOC100912469 Pctp Pla2g4a Cbr4 LOC102556347 Acot7 Acot9 Ppard Acadl Acot2 Cyp2j10 Acads Acot5 Acadm Acaa1a Acaa1b Akr1c2 Scd4 Hao2 Akr1c3 Ptges3 Ptges3l1 LOC100911186 Them5 Acsf2 Scd1 Scd2 Acsf3 Dbi Them4 Morc2 Akr1c1 LOC100911941 Fads1 Dpep2 Ptges Faah Elovl1 Elovl5 Slc25a1 Elovl2 Elovl3 Crot Elovl6 Morc2b Decr1 Hacd1 Hadh Hadha Hadhb Cyp8b1 Crat Pccb Hacd4 Hacd3 Hsd17b12 TNF RECEPTOR SUPERFAMILY (TNFSF) MEMBERS MEDIATING NON-CANONICAL NF-KB PATHWAY%REACTOME DATABASE ID RELEASE 66%10145372 TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway Tnfsf13b Cd40lg Birc3 Birc2 Cd40 Traf3 Prmt2 Traf2 Tnfrsf11a Map3k14 Tnfsf14 Tnfsf12 Tnfrsf12a Tnfrsf13c Tnfsf11 Lta Ltb Ltbr VEGFR2 MEDIATED VASCULAR PERMEABILITY%REACTOME%R-RNO-5218920.1 VEGFR2 mediated vascular permeability Mtor Ctnna1 Vav3 LOC103692716 Mlst8 Trib3 Jup Akt1 Rac1 Pdpk1 Mapkap1 Akt3 Nos3 Pak2 Pak3 Pak1 Ctnnd1 Vav2 Them4 Cdh5 Vav1 Akt2 Rictor PI5P, PP2A AND IER3 REGULATE PI3K AKT SIGNALING%REACTOME%R-RNO-6811558.1 PI5P, PP2A and IER3 Regulate PI3K AKT Signaling Ereg Cd80 Nrg1 Cd86 Btc LOC102552659 Erbb3 Erbb2 Nrg3 Egfr Hbegf Esr2 Rac1 Traf6 Nrg4 Fgf23 Fgf22 Fgf4 Fgf1 Il33 Fgf3 Fgf6 Fgf5 Fgf20 Gab1 Pip5k1c Pip5k1b Fgf16 Fyn Pip5k1a Fgf17 Irs2 Fgf10 Fgf9 Fgfr2 Fgf7 Cd19 Fgf2 Fgf8 Fgfr3 Il1rap Fgfr1 LOC100909468 Fgfr4 Hgf Esr1 Insr Ins1 Rac2 Ins2 Fgf19 Erbb4 Irs1 Frs2 Pip4k2b Pip4k2c Nrg2 Src Ppp2r5e Pik3r1 Pik3r3 Pdgfra Pik3r2 Pdgfrb Pik3ap1 Il1rl1 Akt1 Cd28 Icos Ppp2r5c Ppp2cb Pdgfa Ier3 Ppp2r5a Ppp2ca Pdgfb Ppp2r1a Ppp2r5b Pik3cd Vav1 Irak4 Ppp2r1b Mapk1 Pik3cb Ptpn11 Rhog Kit Myd88 Kitlg Grb2 FGFR1 LIGAND BINDING AND ACTIVATION%REACTOME%R-RNO-190242.1 FGFR1 ligand binding and activation Fgf17 Fgf10 Fgf9 Fgf2 Fgf8 Fgfr1 Fgf23 Fgf22 Fgf4 Fgf1 Fgf3 Fgf6 Fgf5 Fgf20 SYNTHESIS OF PIPS AT THE ER MEMBRANE%REACTOME DATABASE ID RELEASE 66%10145900 Synthesis of PIPs at the ER membrane Mtmr2 Sbf1 Sacm1l Pi4k2b RHO GTPASES ACTIVATE IQGAPS%REACTOME DATABASE ID RELEASE 66%10146088 RHO GTPases activate IQGAPs Men1 Ctnna1 Iqgap3 Iqgap1 Rac1 Cdh1 Cdc42 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 66%10145527 Recruitment of NuMA to mitotic centrosomes Dync1i2 Tubgcp2 Cep57 LOC691918 Haus3 Ninl Akap9 Ccp110 Dync1h1 Pafah1b1 LOC103692716 Numa1 Dctn1 Cntrl Dctn2 Cep76 Pcm1 Cep78 LOC100911033 Cep164 Dctn3 Cep41 Ofd1 Sdccag8 Tubb5 Prkar2b Cenpj Ywhag Ppp2r1a Plk4 Ywhae LOC100912076 Tubg2 Haus2 Haus1 Haus5 Alms1 Haus4 Clasp1 Odf2 Tubb4a Cdk1 Nek2l1 Ssna1 Mapre1 Tubg1 Cep63 Prkaca Csnk1d Cep131 Tuba4a Cep250 Cep135 Csnk1e Ckap5 Cdk5rap2 Nme7 Tubgcp5 Pcnt Nek2 Tubgcp6 Cep72 Tubgcp3 Sfi1 Tubgcp4 Cep70 Actr1a Mzt1 Nedd1 Mzt2b GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION%REACTOME%R-RNO-163841.1 Gamma carboxylation, hypusine formation and arylsulfatase activation Dph1 Ggcx Dph3 Dohh Dph2 Dph5 Gas6 Eif5a2 Dph6 Fn3krp Arsa Furin Arsi Eif5a Arse Icmt Arsg Proz Arsk Sts Arsb Sumf2 Fn3k Sumf1 Pros1 Eef2 Bglap F2 Dhps F7 F9 GLYCINE DEGRADATION%REACTOME DATABASE ID RELEASE 66%10146148 Glycine degradation Amt Gcsh Dld Gldc TANDEM PORE DOMAIN POTASSIUM CHANNELS%REACTOME DATABASE ID RELEASE 66%10145839 Tandem pore domain potassium channels Kcnk16 Kcnk1 Kcnk13 Kcnk2 Kcnk3 LOC100909725 Kcnk4 Kcnk18 Kcnk10 Kcnk6 Kcnk9 Kcnk7 DEGRADATION OF THE EXTRACELLULAR MATRIX%REACTOME%R-RNO-1474228.1 Degradation of the extracellular matrix Cd44 Capn5 RGD1308751 Capn7 Capn9 Capn8 LOC683849 Furin Tpsb2 Cts8l1 Spock3 Htra1 Nid1 LOC100910122 Bmp1 Cast Elane Adam8 Bsg Col13a1 LOC103690254 Try10 LOC100365995 Timp2 Timp1 Phykpl Cma1 Cdh1 Col18a1 MGC114246 A2m Capn15 Capn1 Capn6 Scube3 Scube1 Capn3 Capn2 Capn10 Testin Plg Capn12 Capn11 Capn13 Mmp8 Mmp7 Col19a1 Mmp9 Try4 Mmp1 Mmp2 Lamc2 Acan Adam15 Bcan Klk7 Prss2 LOC100910284 LOC100364523 Ctrb1 Optc Lamb3 Prss1 Spp1 Mmp15 Mmp17 Mmp11 Mmp12 Mmp14 Mmp13 Mmp19 Adamts4 Dcn Adamts5 Klkb1 Ctsd Ctsb Ctsg Ctsl Ctsm Ctsj RGD1564657 Ctsk Ctsq Ctsr LOC102554637 Tll2 Mmp20 Tmprss6 Tll1 Tpsab1 Mmp24 Cts8 Cts7 Col26a1 RGD1564827 Mmp16 Mmp10 ACYL CHAIN REMODELLING OF PG%REACTOME DATABASE ID RELEASE 66%10145863 Acyl chain remodelling of PG Lpcat4 Pla2r1 Pla2g3 Lpcat1 Pla2g5 Pla2g4b Pla2g4d Lpgat1 Pla2g2a Pla2g2f LOC317456 Pla2g2d Pla2g10 Pla2g1b Pla2g4a Crls1 Pla2g12a ACYL CHAIN REMODELING OF DAG AND TAG%REACTOME%R-RNO-1482883.1 Acyl chain remodeling of DAG and TAG Pnpla3 Awat2 Pnpla2 LOC100911615 Mgll Dgat2 Dgat2l6 Dgat1 NUCLEAR ENVELOPE BREAKDOWN%REACTOME DATABASE ID RELEASE 66%10145982 Nuclear Envelope Breakdown Nup93 Nup43 Nup98 Nup133 Nup107 Aaas Nup155 Lemd3 Lmna Nup210 Npap60 Nup35 Ctdnep1 Nup88 Nup37 Prkcb Nupl2 Tmpo Nupl1 Nup85 Nup153 Cnep1r1 Tpr Cdk1 Lmnb1 Rae1 Lemd2 Nup54 Lpin2 Prkca Lpin3 Lpin1 Nup205 Pom121 Nek6 Ranbp2 Nup62 Nek7 APC:CDC20 MEDIATED DEGRADATION OF CELL CYCLE PROTEINS PRIOR TO SATISFATION OF THE CELL CYCLE CHECKPOINT%REACTOME%R-RNO-179419.1 APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint Psmc6 Psmb10 Psmb8 Psmb9 Psmb4 Psmb11 Bub3 Psmb5 Psmf1 Psmb6 Psmd4 Psmb2 Psmd5 Psmd8 Psmd9 Psmb3 Psma8 Psmd11 Psmd12 Anapc11 Ccna2 Ccna1 Anapc15 Psmd13 Anapc10 Psmd14 Psmc3 G6pc Ube2d1 Cdc20 Psmb7 Psmb1 Bub1b Mad2l1 Anapc7 Cdc26 Cdc27 Cdc23 Psma5 Ube2c Cdk1 Anapc16 Cdc16 Nek2l1 Anapc4 Psma2 Anapc2 Anapc1 Psmc5 Psmd2 Psma1 Psma4 Psmc1 Psma3 Psmc4 Psmc2 Psma6 Psme1 Nek2 Psmd1 Psme2 Psmd7 Psmd3 Psmd6 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC%REACTOME DATABASE ID RELEASE 66%10145414 Antigen Presentation: Folding, assembly and peptide loading of class I MHC RT1-CE2 RT1-CE3 Sec24a RT1-CE4 Sec24b RT1-CE7 RT1-CE5 Sec24d RT1-CE10 Canx RT1-A Calr RT1-A2 RT1-M3-1 Erap1 RT1-A1 Hspa5 B2m Tap1 Sec23a Tap2 RT1-M6-1 Sec31a LOC683761 LOC100364956 Sec13 RT1-M2 RT1-M6-2 Sar1b LOC100364500 RT1-M5 Tapbp RT1-M4 RT1-S3 Sec24c BLOCH PATHWAY%REACTOME%R-RNO-6807047.1 Bloch pathway Ebp Dhcr7 Sc5d Dhcr24 RNA POLYMERASE I PROMOTER ESCAPE%REACTOME%R-RNO-73772.1 RNA Polymerase I Promoter Escape Gtf2h1 Gtf2h2 Mnat1 RGD1565904 Ubtf Polr1b Taf1d Ercc3 Taf1c Polr2h Cd3eap Polr2e Znrd1 Polr2f Polr1c Polr2k Polr1a Ercc2 LOC100912534 Rrn3 Cdk7 Twistnb Polr1e Ccnh Gtf2h3 Tbp Gtf2h5 LOC100910121 Gtf2h4 HDR THROUGH MMEJ (ALT-NHEJ)%REACTOME DATABASE ID RELEASE 66%10146137 HDR through MMEJ (alt-NHEJ) Rbbp8 Xrcc1 Parp2 Fen1 Parp1 Lig3 Polq Nbn Rad50 Mre11a ALPHA-DEFENSINS%REACTOME%R-RNO-1462054.1 Alpha-defensins Defa7 Np4 Defa11 RatNP-3b Defa10 Defa5 Cd4 Art1 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE%REACTOME DATABASE ID RELEASE 66%10145161 Toll Like Receptor 3 (TLR3) Cascade Map2k7 Ripk2 Map2k6 Ager Dusp3 Irf3 Map2k4 Map3k8 Dusp4 Nfkbib Traf6 Cul1 Vrk3 Rps6ka2 Rps6ka1 App Rps6ka3 Rps6ka5 LOC100912585 Tab1 Dusp7 Dusp6 Rela Atf1 Atf2 Map3k7 Irak2 Nfkbia LOC100910771 Ube2n Jun Ppp2cb Ppp2ca Skp1 Ppp2r1a Nfkb2 Nfkb1 Mapk9 Mapk8 Fos S100b Mapk7 Dhx9 Fbxw11 Chuk Ppp2r1b Mapkapk3 Btrc Mapkapk2 Mapk1 Nkiras1 LOC100362142 Nod1 Nod2 Nkiras2 Creb1 Tab2 Tab3 LOC100912618 Ube2v1 Ikbkb Mapk14 Myd88 Tnip2 Mapk11 Mapk10 MET INTERACTS WITH TNS PROTEINS%REACTOME DATABASE ID RELEASE 66%10146251 MET interacts with TNS proteins Hgf Tns4 INTERFERON GAMMA SIGNALING%REACTOME%R-RNO-877300.1 Interferon gamma signaling Prkcd Camk2g Socs1 Sumo1 Stat1 Jak1 Ifngr2 Pias1 Ifngr1 Camk2d Camk2a Socs3 Ptpn2 Ptpn6 Ifng MAJOR PATHWAY OF RRNA PROCESSING IN THE NUCLEOLUS AND CYTOSOL%REACTOME%R-RNO-6791226.1 Major pathway of rRNA processing in the nucleolus and cytosol Rps20 Rps27l LOC100360573 Rps4x LOC100359951 LOC100359593 LOC100359503 LOC100362640 Rps3 Rps15a Rps2 Rps13 Rps12 LOC100911372 LOC100361854 LOC684988 LOC103689992 Rps5 Rps7 Rps6 LOC100362830 LOC100363012 LOC100362149 Exosc3 Exosc9 LOC100359574 Exosc2 Exosc1 Exosc4 Exosc7 Exosc5 Dcaf13 Tbl3 Tsr1 Emg1 Wdr75 Wdr18 Wdr43 Wdr46 Nhp2l1 C1d Nob1 Fcf1 Wdr12 Senp3 Wdr36 Ebna1bp2 Rpp25 Riok3 Riok1 Utp14a Bysl NEWGENE_1564769 Rpp21 Pdcd11 Rpp40 Skiv2l2 Heatr1 Riok2 Rpp38 Rrp36 Rpp30 Bop1 Utp20 Dhx37 Utp18 Gnl3 Utp15 Utp11l Pno1 Pwp2 Wbscr22 Mphosph6 Imp4 Imp3 Nop56 Tex10 Utp6 Rcl1 Nol6 Utp3 Ncl Nop14 Xrn2 Rrp9 Rrp7a Pes1 Exosc10 Krr1 Nol9 Mphosph10 LOC100910568 Rpp14 Cirh1a Diexf Nop58 Ddx52 Rps16 Ltv1 Wdr3 Noc4l Ddx49 Ddx47 Las1l Fbl Rps18 LOC100360679 Rps15 Ddx21 Rps3a Csnk1d Csnk1e MET ACTIVATES STAT3%REACTOME%R-RNO-8875791.1 MET activates STAT3 Hgf Stat3 ERYTHROCYTES TAKE UP CARBON DIOXIDE AND RELEASE OXYGEN%REACTOME DATABASE ID RELEASE 66%10145817 Erythrocytes take up carbon dioxide and release oxygen Cyb5r2 Cyb5rl Rhag Hbb-b1 Hba1 Car2 Aqp1 Slc4a1 Cyb5r1 Car1 LOC287167 RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN BCR SIGNALING%REACTOME DATABASE ID RELEASE 66%10146269 RUNX1 regulates transcription of genes involved in BCR signaling Cbfb Elf2 Pax5 Runx1 G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%R-RNO-1296059.1 G protein gated Potassium channels Kcnj4 Kcnj6 Kcnj16 Gnb3 Gnb2 Gnb1 Gng12 Kcnj2 Kcnj3 Kcnj15 Kcnj9 Kcnj5 Gng4 Gngt2 Gabbr1 Gng5 Kcnj12 Gngt1 Gng10 Gng8 Gabbr2 Gng3 CLEARANCE OF SERATONIN%REACTOME%R-RNO-380615.1 Clearance of seratonin Maoa Aldh2 Slc6a4 MITOTIC PROMETAPHASE%REACTOME DATABASE ID RELEASE 66%10145506 Mitotic Prometaphase Cenpn Zwilch Cenpl Nup43 Cenpo Nup133 Dync1li2 Cenpt Cenpu Bub3 Bub1 Spdl1 Kntc1 Dync1i2 LOC100910252 Csnk2a2 Mad1l1 Cep57 Stag1 Cenpk Cenph LOC691918 Nup37 Cenpi Haus3 Csnk2a1 Pds5b Pds5a Cenpf Cdca5 Ninl Rad21 Cenpe Akap9 Smc1a Cenpm Stag2 Smc3 Ccp110 Ahctf1 Ndel1 Rcc2 Pafah1b1 Mis12 Dynll2 Ndc80 Cenpc Cenpa Dync1i1 Ranbp2 Birc5 Taok1 Tubb5 Ppp2cb Ppp2ca Ywhag Ppp2r1a Nup85 Ywhae Ppp2r1b Nek2l1 Prkaca Nek2 Nup98 Nup107 Tubgcp2 Dync1h1 Cdca8 Dync1li1 Rangap1 LOC103692716 Ppp1cc LOC100909468 Aurkb Numa1 Sec13 Xpo1 LOC100911204 Spc24 Spc25 Hdac8 Itgb3bp Sgol2 Dctn1 Cntrl Dctn2 Ppp2r5e Cep76 Incenp Pcm1 Cep78 Ncapg Nsl1 B9d2 LOC100911033 Cdc20 Cep164 Kif2a Dctn3 Kif2c Ofd1 Cep41 Kif2b Bub1b Sdccag8 Kif18a Ppp2r5c Ppp2r5a Prkar2b Cenpj Ppp2r5b Plk4 Zwint Smc4 Dsn1 Mad2l1 Smc2 Casc5 LOC100912076 Clasp2 Tubg2 Csnk2b Ercc6l Haus2 Haus1 Nuf2 Haus5 Alms1 Haus4 Clasp1 Odf2 LOC679582 Tubb4a Cdk1 Ssna1 Tubg1 Mapre1 Cep63 Cdc42 Csnk1d Cep131 Pmf1 Tuba4a Cep250 Cep135 Csnk1e Cdk5rap2 Ckap5 Nme7 Tubgcp5 Ska2 Pcnt Tubgcp6 Cep72 Tubgcp3 Sfi1 Tubgcp4 Cep70 Sgol1 Actr1a Zw10 Nedd1 Mzt1 Mzt2b Ska1 PLATELET SENSITIZATION BY LDL%REACTOME DATABASE ID RELEASE 66%10145634 Platelet sensitization by LDL Lrp8 Pla2g4a Fgr Apob Mapk14 Gnaq Gna11 Gna14 Gna15 REGULATION OF RUNX2 EXPRESSION AND ACTIVITY%REACTOME%R-RNO-8939902.1 Regulation of RUNX2 expression and activity Psmc6 Psmb10 G6pc Psmb8 Psmb9 Psmb4 Psmb5 Psmf1 Psmb6 Psmd4 Psmb2 Cul1 Rbx1 Psmd5 Psmd8 Psmb7 Psmd9 Psmb1 Psmb3 Skp1 Psmd11 Psmd12 Psmd13 Psmd14 Stub1 Psma5 Runx2 Skp2 Psma2 Psmc3 Psmc5 Psmd2 Psma1 Psma4 Psmc1 Psma3 Psmc4 Psmc2 Psma6 Psme1 Psmd1 Psme2 Psmd7 Psmd3 Psmd6 RAB GERANYLGERANYLATION%REACTOME%R-RNO-8873719.1 RAB geranylgeranylation Rab2a Rab2b Rab35 Rab34 Rab36 Rabggta Rab18 Rab8a Rab10 Rab27a Rab14 Rab3c Rab24 Rab3b Rab43 Rab7l1 Rab25 Rab20 Rab21 Rab19 Rab23 Rab15 Rab12 LOC102555167 Rab13 Rabggtb Rab32 Rab30 Rab39a Rab38 Rab11b Ptp4a2 Rab1b Rab1a Rab3d Rab4a Rab6b Rab27b Rab9a Rab3a Rab7a Rab4b Rab22a Rab8b Rab40c Rab40b Rab5b Rab5c Chm Rab11a Rab6a Rab7b Rab33a Rab33b Rab9b LOC100363782 NEUROTRANSMITTER UPTAKE AND METABOLISM IN GLIAL CELLS%REACTOME%R-RNO-112313.1 Neurotransmitter uptake and metabolism In glial cells Slc1a3 Slc38a1 Glul RAB GEFS EXCHANGE GTP FOR GDP ON RABS%REACTOME%R-RNO-8876198.1 RAB GEFs exchange GTP for GDP on RABs Trappc10 Madd Sbf1 Rab35 Rin3 Rab18 Rgp1 Rab8a Ulk1 Sbf2 Rab10 Rab27a Rab14 Trappc2l Gapvd1 Rab21 Dennd3 Trappc6a Trappc6b Rab12 Rab3ip Rab13 LOC102555167 Hps4 Rab32 Gdi2 Rab39a Hps1 Mon1b Mon1a Rab38 Rab1b Rab1a Dennd1a Trappc12 Trappc11 Akt2 Dennd1b Trappc2 Trappc5 Rab6b Rab27b Rab9a Ric1 Rab3a Akt1 Ccz1b St5 Rab7a Rab3gap2 Dennd6b Dennd6a Ywhae Trappc3 Rab8b Dennd5a LOC100910318 Rab3il1 Chm Trappc8 Rab6a Dennd4a Dennd4b Rab7b Akt3 Dennd2a Dennd2d Dennd2c Trappc13 Rab9b LOC100363782 Trappc1 PRESYNAPTIC DEPOLARIZATION AND CALCIUM CHANNEL OPENING%REACTOME%R-RNO-112308.1 Presynaptic depolarization and calcium channel opening Cacnb4 Cacna1e Cacnb1 Cacnb2 Cacna2d3 Cacng2 Cacna1b Cacna2d2 Cacng4 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING%REACTOME DATABASE ID RELEASE 66%10144894 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening Gtf2h1 Gtf2h2 Gtf2e1 Gtf2e2 Mnat1 RGD1565904 Taf11 Polr2g Ercc3 Taf2 Polr2h Taf15 Polr2e Polr2f Polr2j Taf13 Taf9 Polr2k Taf12 Polr2d LOC100911822 Taf7 Polr2i Taf4b Polr2b Polr2c Taf3 Ercc2 Taf6 Polr2a Taf5 Gtf2f1 LOC100912534 Gtf2f2 Gtf2a1 Cdk7 Atp5c1 Taf10 Taf7l Gtf2b Ccnh Gtf2h3 Gtf2h5 Tbp Gtf2h4 Taf9b HISTIDINE CATABOLISM%REACTOME%R-RNO-70921.1 Histidine catabolism Amdhd1 Carns1 Hnmt Hal Hdc Ftcd Uroc1 SIGNALING BY HIPPO%REACTOME DATABASE ID RELEASE 66%10145927 Signaling by Hippo Sav1 Amot LOC100361515 Dvl2 Casp3 Stk4 Stk3 Yap1 Mob1b Mob1a Wwc1 Lats1 Wwtr1 Tjp2 Ywhab Nphp4 Ywhae Amotl2 RIBOSOMAL SCANNING AND START CODON RECOGNITION%REACTOME DATABASE ID RELEASE 66%10144836 Ribosomal scanning and start codon recognition LOC100912571 Eif3l Eif2s3 Eif3m Eif3j Eif3k Rps20 Rps27l Eif3e Eif3f Eif3b Eif3a Eif3d Eif3c LOC100360573 Eif2s1 Eif2s2 Eif4g1 Rps4x LOC100359951 LOC100359593 Eif5 LOC100359503 LOC100362640 Rps3 Rps15a Rps2 Rps13 Rps12 LOC100911372 LOC100361854 LOC684988 LOC103689992 Rps5 Rps7 Rps6 Eif3g Eif3h Eif4a2 LOC100362830 Eif1ax Eif4a1 LOC100363012 LOC680559 LOC100911110 LOC100362149 Rps16 LOC100911431 Rps18 LOC100360679 Rps15 Eif4h Eif4b Rps3a PLATELET AGGREGATION (PLUG FORMATION)%REACTOME DATABASE ID RELEASE 66%10145477 Platelet Aggregation (Plug Formation) Src Ptpn1 Akt1 Fn1 Adra2a Csk Tln1 Crk Adra2c Rasgrp1 Rasgrp2 Rap1a Vwf Adra2b Apbb1ip Bcar1 Fgb Fgg Pdpk1 Gp1ba Gp9 Rapgef4 Gp5 Gp1bb LOC100911551 Fga Itga2b F2 Ptk2 Sos1 Shc1 Syk Grb2 HEME BIOSYNTHESIS%REACTOME%R-RNO-189451.1 Heme biosynthesis Cpox Fech Alad LOC687381 Ppox Hmbs Cox10 Alas2 LOC100911779 Cox15 Urod Uros NOD1 2 SIGNALING PATHWAY%REACTOME%R-RNO-168638.1 NOD1 2 Signaling Pathway Ripk2 Map2k6 Birc3 Birc2 Cyld Traf6 Tab1 Casp4 Casp1 Casp2 Map3k7 Casp8 Casp9 Tnfaip3 Irak2 Mapk13 Mapk12 Chuk LOC100362142 Nod1 Nod2 LOC100910771 Tab2 Ube2n Tab3 LOC100912618 Ube2v1 Ikbkb Mapk14 Mapk11 INTERLEUKIN-4 AND INTERLEUKIN-13 SIGNALING%REACTOME%R-RNO-6785807.1 Interleukin-4 and Interleukin-13 signaling Jak3 Socs1 Stat1 Il2rg Il4 Stat6 Jak1 Stat3 Il13 Il13ra1 Socs5 Hsp90b1 Il13ra2 LOC100360218 Tyk2 Il4r RELAXIN RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145665 Relaxin receptors Rln3 Rxfp1 Rxfp2 Insl3 Rxfp3 ORGANIC CATION ANION ZWITTERION TRANSPORT%REACTOME%R-RNO-549132.1 Organic cation anion zwitterion transport Slc22a7 Slc22a1 Slc22a15 Slc22a2 Slc22a6 Slc22a3 Runx1 Slc22a5 CARNITINE SYNTHESIS%REACTOME DATABASE ID RELEASE 66%10144812 Carnitine synthesis Shmt1 Tmlhe CAM-PDE 1 ACTIVATION%REACTOME DATABASE ID RELEASE 66%10145008 Cam-PDE 1 activation Pde1b HDR THROUGH SINGLE STRAND ANNEALING (SSA)%REACTOME DATABASE ID RELEASE 66%10144912 HDR through Single Strand Annealing (SSA) Rhno1 Rfc2 Bard1 Wrn Topbp1 Rbbp8 Rmi1 Rmi2 LOC100911267 Hus1 Rad51 Rad50 Rad52 Rpa1 Rpa2 Ercc1 Atm Atrip LOC100909750 Rpa3 Rad1 Brca1 Atr Blm Rad17 Slc25a16 Rfc5 Rfc4 Rad9a Nbn Rfc3 Rad9b Abl1 Mre11a FASL CD95L SIGNALING%REACTOME%R-RNO-75157.1 FasL CD95L signaling Faslg Fadd Casp8 Fas SUMO IS PROTEOLYTICALLY PROCESSED%REACTOME%R-RNO-3065679.1 SUMO is proteolytically processed Senp2 LOC690251 Senp1 Sumo1 Sumo3 Senp5 MAP2K AND MAPK ACTIVATION%REACTOME%R-RNO-5674135.1 MAP2K and MAPK activation Src Kras Ksr1 Wdr83 Ksr2 Raf1 Vcl Il17rd Cnksr1 Cnksr2 Lamtor3 Ywhab Fn1 Pbp2 Lamtor2 Csk Tln1 Vwf Rap1a Apbb1ip Pebp1 Fgb Fgg Mark3 Araf Mapk1 Arrb1 Arrb2 Fga Itga2b Hras Nras Iqgap1 Map2k2 ACTIVATION OF RAS IN B CELLS%REACTOME%R-RNO-1169092.1 Activation of RAS in B cells Kras Rasgrp1 Hras Nras Rasgrp3 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1%REACTOME DATABASE ID RELEASE 66%10145226 SCF-beta-TrCP mediated degradation of Emi1 Psmc6 Psmb10 G6pc Psmb8 Psmb9 Psmb4 Psmb11 Psmb5 Psmf1 Psmb6 Cdc20 Psmd4 Psmb2 Cul1 Psmd5 Psmd8 Psmb7 Psmd9 Psmb1 Psmb3 Psma8 Skp1 Psmd11 Psmd12 Psmd13 Psmd14 Fzr1 Fbxo5 Psma5 Btrc Psma2 Psmc3 Psmc5 Psmd2 Psma1 Psma4 Psmc1 Psma3 Psmc4 Psmc2 Psma6 Psme1 Psmd1 Psme2 Psmd7 Psmd3 Psmd6 ETHANOL OXIDATION%REACTOME DATABASE ID RELEASE 66%10144819 Ethanol oxidation Adh4 Acss2 Adh6 Adh7 Aldh2 Aldh1b1 Acss1 RHO GTPASES REGULATE CFTR TRAFFICKING%REACTOME DATABASE ID RELEASE 66%10146090 RHO GTPases regulate CFTR trafficking Rhoq FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF)%REACTOME DATABASE ID RELEASE 66%10146023 Formation of Senescence-Associated Heterochromatin Foci (SAHF) Asf1a Ubn1 Cabin1 LOC100911837 Hira GOLGI-TO-ER RETROGRADE TRANSPORT%REACTOME%R-RNO-8856688.1 Golgi-to-ER retrograde transport Kif21a Kif21b Kifc1 Kif3c Racgap1 Pla2g6 Klc1 Arf5 Kif22 Dync1li2 Kif3b Copa Kif23 Kif18b Kifap3 Kif11 Kif12 Kif4a Kif6 Kif1a Kif1c Dync1i2 Arf4 Gbf1 Klc4 Kif27 Kif9 Cenpe Kif13b Klc2 Klc3 Pafah1b1 Kif3a LOC102555167 Dynll2 Dync1i1 Copz2 Copz1 Tmed7 Tmed3 Tmed2 Rab6b Napg Napb Napa Copb1 Rab3gap2 Tmed9 Bicd2 Nsf Bicd1 Kdelr1 Agpat3 Capza2 Capza3 Rab6a Arcn1 Kif20b Kif16b Kif26a Kif20a Kif26b Kif19 Kdelr2 Galnt1 Pafah1b3 Kdelr3 Galnt2 Bnip1 Use1 Rab18 Pla2g4a Actr10 Stx18 Dync1h1 Dync1li1 Copg1 Dctn5 Dctn6 Rab1b Rab1a Dctn4 Nbas Dctn1 Arfgap2 Dctn2 Arfgap3 Dctn3 Arfgap1 Kif2a Kif2c Kif2b Kif18a Capzb Kif5b Kif5a Sec22b Cope Actr1a Zw10 LOC100363782 Tmed10 REGULATION OF TP53 ACTIVITY THROUGH METHYLATION%REACTOME DATABASE ID RELEASE 66%10146002 Regulation of TP53 Activity through Methylation LOC100909949 Mdm2 Smyd2 LOC100910954 Mdm4 Chek2 Ehmt2 Ehmt1 Prmt5 Setd8 L3mbtl1 Ttc5 Atm RESPIRATORY ELECTRON TRANSPORT%REACTOME%R-RNO-611105.1 Respiratory electron transport Ndufab1 Mt-nd4 Ndufa7l Mt-nd5 Etfa Ndufaf7 Etfb Ndufa7 LOC683884 Ndufaf5 Mt-nd6 Nubpl Mt-nd2 LOC100911483 Ndufb10 Ndufb11 Ndufa12 Ndufa11 Ndufa13 Ndufa10 Ndufb6 Ndufb3 LOC100912599 Ndufb5 LOC100361505 Ndufc2 Ndufb9 Ndufb4 Ndufb8 Ndufb7 Ndufaf3 Ndufaf1 Ndufa2 Ndufa5 Ndufaf4 Ndufa6 RGD1306782 Ndufa1 Ndufs3 Ndufs1 Ndufs4 Ndufs5 Ndufs2 Ndufs8 Coq10a Ndufs6 Ndufs7 Timmdc1 LOC684509 Acad9 Ndufb2 LOC679739 Etfdh LOC679195 LOC100910710 LOC680288 Ecsit LOC688963 Tmem126b LOC100363268 Ndufv3 LOC100361144 Ndufv1 Ndufv2 REVERSIBLE HYDRATION OF CARBON DIOXIDE%REACTOME%R-RNO-1475029.1 Reversible hydration of carbon dioxide Car6 Car13 Car12 Car3 Car7 Car9 Car5a Car14 Car5b Car2 Car1 SENSING OF DNA DOUBLE STRAND BREAKS%REACTOME%R-RNO-5693548.1 Sensing of DNA Double Strand Breaks LOC100359600 Nbn Rad50 Atm Mre11a Kpna2 NOSIP MEDIATED ENOS TRAFFICKING%REACTOME DATABASE ID RELEASE 66%10145408 NOSIP mediated eNOS trafficking Nosip Nos3 BIOSYNTHESIS OF PROTECTIN AND RESOLVIN CONJUGATES IN TISSUE REGENERATION (PCTR AND RCTR)%REACTOME%R-RNO-9026766.1 Biosynthesis of protectin and resolvin conjugates in tissue regeneration (PCTR and RCTR) Ltc4s COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES%REACTOME%R-RNO-1650814.1 Collagen biosynthesis and modifying enzymes Col19a1 Pcolce Col22a1 Col16a1 Col5a2 Col5a1 Col4a5 Col9a1 Col27a1 Col9a2 Col9a3 Col4a1 Col5a3 Bmp1 Col4a2 Col4a3 Crtap Col7a1 Col23a1 Col6a5 Col6a6 Col20a1 P4ha1 P4ha2 P4ha3 LOC100910835 Col13a1 LOC100910384 Adamts3 Serpinh1 Col8a1 Col8a2 Col3a1 Col28a1 Col1a1 Col1a2 Ppib Col6a1 Col6a2 Col18a1 P4hb Adamts14 Tll2 Col11a2 Col11a1 Tll1 LOC100911572 P3h3 Colgalt2 Col26a1 Col14a1 Plod2 Plod1 Colgalt1 LOC102555086 Plod3 Col17a1 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6%REACTOME%R-RNO-69017.1 CDK-mediated phosphorylation and removal of Cdc6 Psmc6 Psmb10 Psmb8 Psmb9 Psmb4 Psmb11 Psmb5 Psmf1 Psmb6 Psmd4 Psmb2 Psmd5 Psmd8 Psmd9 Psmb3 Psma8 Psmd11 Psmd12 Ccna2 Anapc11 Ccne2 Ccna1 Anapc15 Psmd13 Anapc10 Psmd14 Ccne1 Fzr1 Cdk2 Psmc3 Cdc6 G6pc Ube2d1 Psmb7 Psmb1 Anapc7 Cdc26 Cdc27 Psma5 Cdc23 Ube2c Anapc16 Cdc16 Anapc4 Psma2 Anapc2 Anapc1 Psmc5 Psmd2 Psma1 Psma4 Psmc1 Psma3 Psmc4 Psmc2 Psma6 Psme1 Psmd1 Psme2 Psmd7 Psmd3 Psmd6 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24-HYDROXYCHOLESTEROL%REACTOME%R-RNO-193775.1 Synthesis of bile acids and bile salts via 24-hydroxycholesterol Amacr Akr1d1 Cyp39a1 Ptgis Akr1c2 Akr1c3 Akr1c12l1 Slc27a2 Cyp46a1 Cyp8b1 Akr1c19 Slc27a5 Akr1c13 Akr1c14 RGD1564865 Hsd3b7 Akr1c12 Akr1c1 RUNX3 REGULATES CDKN1A TRANSCRIPTION%REACTOME%R-RNO-8941855.1 RUNX3 regulates CDKN1A transcription Smad3 LOC100910954 Tgfb1 Zfhx3 INTERLEUKIN-6 FAMILY SIGNALING%REACTOME%R-RNO-6783589.1 Interleukin-6 family signaling Stat1 Crlf1 Cntfr Jak1 Lif Il6 Il6st Osm Stat3 Cbl Il11ra1 Lifr Socs3 Clcf1 Ptpn11 Il11 Il31ra Ctf1 Cntf Osmr Tyk2 NA+ CL- DEPENDENT NEUROTRANSMITTER TRANSPORTERS%REACTOME%R-RNO-442660.1 Na+ Cl- dependent neurotransmitter transporters Slc6a11 Slc6a13 Slc6a1 Slc6a12 Slc6a2 Slc18a1 Slc22a1 Slc6a15 Slc22a2 Slc6a7 Slc6a14 Slc6a19 Slc6a18 Slc6a9 Slc6a3 Slc6a20 Slc6a6 Slc6a5 REGULATION OF MITOTIC CELL CYCLE%REACTOME%R-RNO-453276.1 Regulation of mitotic cell cycle Psmc6 Psmb10 Psmb8 Psmb9 Psmb4 Psmb11 Bub3 Psmb5 Psmf1 Psmb6 Psmd4 Psmb2 Cul1 Psmd5 Psmd8 Psmd9 Psmb3 Psma8 Psmd11 Psmd12 Ccna2 Anapc11 Ccna1 Anapc15 Aurka Psmd13 Psmd14 Anapc10 Fzr1 Fbxo5 Cdk2 Aurkb Psmc3 G6pc Ube2d1 Cdc20 Psmb7 Psmb1 Bub1b Skp1 Mad2l1 Anapc7 Cdc26 Cdc14a Cdc27 Cdc23 Psma5 Pttg1 Ube2c Skp2 Cdkn1a Cdkn1b Cdk1 Anapc16 Cdc16 Nek2l1 Btrc Anapc4 Anapc2 Psma2 Anapc1 Psmc5 Psmd2 Psma1 Psma4 Psmc1 Psma3 Psmc4 Psmc2 Psma6 Psme1 Nek2 Psmd1 Psme2 Psmd7 Psmd3 Psmd6 ERKS ARE INACTIVATED%REACTOME DATABASE ID RELEASE 66%10145380 ERKs are inactivated Ppp2cb Dusp3 Ppp2ca LOC100912585 Mapk7 Ppp2r1a Dusp4 Dusp7 Dusp6 Ppp2r1b Mapk1 Vrk3 PRE-NOTCH TRANSCRIPTION AND TRANSLATION%REACTOME DATABASE ID RELEASE 66%10146305 Pre-NOTCH Transcription and Translation Prkci Elf3 VITAMIN B2 (RIBOFLAVIN) METABOLISM%REACTOME DATABASE ID RELEASE 66%10145350 Vitamin B2 (riboflavin) metabolism Rfk Flad1 Enpp1 RGD1563242 Acp5 Slc52a2 Slc52a3 STABILIZATION OF P53%REACTOME%R-RNO-69541.1 Stabilization of p53 Psmc6 Psmb10 Mdm2 G6pc Psmb8 Psmb9 Psmb4 Psmb11 Psmb5 Psmf1 Psmb6 Psmd4 Psmb2 Psmd5 Psmd8 Psmb7 Psmd9 Psmb1 Psmb3 Psma8 Psmd11 Psmd12 Psmd13 Psmd14 Phf20 Atm Psma5 LOC100910954 Mdm4 Chek2 Psma2 Psmc3 Psmc5 Psmd2 Psma1 Psma4 Psmc1 Psma3 Psmc4 Psmc2 Psma6 Psme1 Psmd1 Psme2 Psmd7 Psmd3 Rfwd2 Psmd6 RESPONSE TO METAL IONS%REACTOME DATABASE ID RELEASE 66%10146118 Response to metal ions Mt3 HYALURONAN METABOLISM%REACTOME%R-RNO-2142845.1 Hyaluronan metabolism Cd44 Hexb Lyve1 Stab2 Hexa Has1 Has2 Slc9a1 Gusb Hyal1 Hyal2 Chp1 Cemip ACTIVATION OF NA-PERMEABLE KAINATE RECEPTORS%REACTOME%R-RNO-451307.1 Activation of Na-permeable kainate receptors Grik1 Grik2 ELEVATION OF CYTOSOLIC CA2+ LEVELS%REACTOME%R-RNO-139853.1 Elevation of cytosolic Ca2+ levels P2rx2 P2rx3 P2rx1 Itpr1 P2rx5 P2rx6 Itpr3 P2rx4 Trpc3 Trpc7 Trpc6 P2rx7 TRANSLESION SYNTHESIS BY POLI%REACTOME DATABASE ID RELEASE 66%10146112 Translesion synthesis by POLI Rfc1 Rfc2 Rpa3 Pcna Poli Rev1 Rpa1 Rpa2 Mad2l2 Rfc5 Rev3l Rfc4 Rfc3 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES)%REACTOME DATABASE ID RELEASE 66%10145812 Cross-presentation of soluble exogenous antigens (endosomes) Psmc6 Psmb10 G6pc Psmb8 Psmb9 Psmb4 Psmb11 Psmb5 Psmf1 Psmb6 Psmd4 Psmb2 Psmd5 Psmd8 Psmb7 Psmd9 Psmb1 Psmb3 Psma8 Psmd11 Psmd12 Mrc2 Psmd13 Mrc1 Psmd14 Fcgr1a Psma5 Cd207 Psma2 Psmc3 Psmc5 Psma1 Psmd2 Psma4 Psmc1 Psma3 Psmc4 Psmc2 Psma6 Psme1 Psmd1 Psme2 Psmd7 Psmd3 Psmd6 GALACTOSE CATABOLISM%REACTOME DATABASE ID RELEASE 66%10144777 Galactose catabolism Gale Pgm2l1 Galk1 Pgm2 Pgm1 Galt ERK MAPK TARGETS%REACTOME DATABASE ID RELEASE 66%10145363 ERK MAPK targets Dusp3 Mapk7 Dusp4 Ppp2r1b Mapk1 Vrk3 Rps6ka2 Rps6ka1 Rps6ka3 Ppp2cb Rps6ka5 Ppp2ca LOC100912585 Ppp2r1a Dusp7 Dusp6 Mapk14 Mapk11 TRANSPORT OF GAMMA-CARBOXYLATED PROTEIN PRECURSORS FROM THE ENDOPLASMIC RETICULUM TO THE GOLGI APPARATUS%REACTOME%R-RNO-159763.1 Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus Pros1 Proz Bglap F2 F7 F9 Gas6 FORMATION OF TC-NER PRE-INCISION COMPLEX%REACTOME DATABASE ID RELEASE 66%10146151 Formation of TC-NER Pre-Incision Complex Gtf2h1 Gtf2h2 Usp7 Ppie Ddb1 Mnat1 Rbx1 RGD1565904 Isy1 Polr2g Polr2h Polr2e Polr2f Polr2j Polr2k Polr2d Polr2i Polr2b Polr2c Polr2a Xab2 Cops8 LOC100912534 Cops2 Zfp830 Prpf19 Tcea1 Cul4b Uvssa Ccnh Cul4a Hmgn1 Xpa Gtf2h3 Gtf2h5 Gtf2h4 Ercc8 Ercc3 Ercc6 LOC100911295 LOC100911822 Cops4 Aqr Cops6 Ercc2 Cops3 Cdk7 Cops7b Cops7a EICOSANOIDS%REACTOME%R-RNO-211979.1 Eicosanoids Cyp4a2 Cyp4f39 LOC100912391 Tbxas1 Cyp4a1 Ptgis Cyp4f17 Cyp4f6 Cyp4a8 Cyp8b1 Cyp4f18 MRNA CAPPING%REACTOME DATABASE ID RELEASE 66%10144929 mRNA Capping Gtf2h1 Gtf2h2 Mnat1 RGD1565904 Ercc3 Polr2g Polr2h Polr2e Polr2f Polr2j Polr2k Polr2d Supt5h LOC100911822 Polr2i Polr2b Polr2c Ercc2 Polr2a Rnmt Rngtt Ncbp2 Gtf2f1 LOC100912534 Gtf2f2 Ncbp1 Cdk7 Ccnh Gtf2h3 Gtf2h5 Gtf2h4 MITOTIC SPINDLE CHECKPOINT%REACTOME DATABASE ID RELEASE 66%10145064 Mitotic Spindle Checkpoint Cenpn Zwilch Cenpl Cenpo Nup43 Nup133 Dync1li2 Cenpt Cenpu Bub3 Bub1 Spdl1 Kntc1 Dync1i2 Mad1l1 Cenpk Cenph Cenpi Nup37 Cenpf Cenpe Cenpm Ahctf1 Ndel1 Rcc2 Pafah1b1 Mis12 Dynll2 Ndc80 Cenpc Cenpa Dync1i1 Ranbp2 Birc5 Taok1 Ube2d1 Ppp2cb Ppp2ca Ppp2r1a Nup85 Anapc7 Cdc26 Cdc27 Cdc23 Ube2c Ppp2r1b Anapc16 Cdc16 Anapc4 Anapc2 Anapc1 Nup98 Nup107 Anapc11 Anapc15 Anapc10 Cdca8 Dync1h1 Dync1li1 Rangap1 Ppp1cc LOC100909468 Aurkb Sec13 Xpo1 LOC100911204 Spc24 Spc25 Itgb3bp Sgol2 Ppp2r5e Incenp Nsl1 B9d2 Cdc20 Kif2a Kif2c Kif2b Bub1b Kif18a Ppp2r5c Ppp2r5a Ppp2r5b Zwint Dsn1 Mad2l1 Casc5 Clasp2 Ercc6l Nuf2 Clasp1 LOC679582 Mapre1 Pmf1 Ckap5 Ska2 Sgol1 Zw10 Ska1 SYNTHESIS OF HEPOXILINS (HX) AND TRIOXILINS (TRX)%REACTOME%R-RNO-2142696.1 Synthesis of Hepoxilins (HX) and Trioxilins (TrX) Alox12 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME%R-RNO-69613.1 p53-Independent G1 S DNA damage checkpoint Psmc6 Psmb10 G6pc Psmb8 Psmb9 Psmb4 Psmb11 Psmb5 Psmf1 Psmb6 Psmd4 Psmb2 Psmd5 Psmd8 Psmb7 Psmd9 Psmb1 Psmb3 Psma8 Psmd11 Psmd12 Psmd13 Psmd14 Psma5 Chek2 Psma2 Psmc5 Psmc3 Psma1 Psmd2 Psma4 Psmc1 Cdc25a Psma3 Psmc4 Psmc2 Psma6 Psme1 Psmd1 Psme2 Psmd7 Psmd3 Psmd6 SHC1 EVENTS IN ERBB2 SIGNALING%REACTOME DATABASE ID RELEASE 66%10145824 SHC1 events in ERBB2 signaling Prkcd Ereg Nrg1 Btc LOC102552659 Erbb3 Erbb2 Nrg3 Egfr Hbegf Nrg4 Prkca Erbb4 Ptpn12 Shc1 Nrg2 ACTIVATION OF MATRIX METALLOPROTEINASES%REACTOME%R-RNO-1592389.1 Activation of Matrix Metalloproteinases Mmp8 Elane Mmp15 Mmp17 Mmp7 Mmp11 Mmp14 Mmp9 Try4 Mmp13 Mmp1 LOC103690254 Mmp2 Klkb1 Try10 LOC100365995 Ctsg Ctsl Timp2 Timp1 Ctsk Cma1 LOC683849 Furin Col18a1 Tpsb2 LOC102554637 Spock3 Prss2 Tpsab1 Mmp24 Ctrb1 Plg Mmp16 Prss1 Mmp10 TANDEM OF PORE DOMAIN IN A WEAK INWARDLY RECTIFYING K+ CHANNELS (TWIK)%REACTOME DATABASE ID RELEASE 66%10145844 Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK) Kcnk1 LOC100909725 Kcnk6 Kcnk7 FRUCTOSE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 66%10146095 Fructose biosynthesis Akr1b1 Sord TRANSLOCATION OF ZAP-70 TO IMMUNOLOGICAL SYNAPSE%REACTOME DATABASE ID RELEASE 66%10145399 Translocation of ZAP-70 to Immunological synapse Cd3g Cd247 Cd3e RT1-Ba Cd3d RT1-Bb RT1-Da RT1-Db2 Cd4 Ptpn22 RT1-Db1 LOC688090 BIOSYNTHESIS OF DPAN-3-DERIVED PROTECTINS AND RESOLVINS%REACTOME%R-RNO-9026286.1 Biosynthesis of DPAn-3-derived protectins and resolvins Alox5 Alox15 REGULATION OF APOPTOSIS%REACTOME DATABASE ID RELEASE 66%10146243 Regulation of Apoptosis Oma1 Opa1 SYNTHESIS OF (16-20)-HYDROXYEICOSATETRAENOIC ACIDS (HETE)%REACTOME%R-RNO-2142816.1 Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) Cyp2c7 Cyp4a2 Cyp1b1 LOC100361547 Cyp4a1 Cyp1a1 Cyp2u1 Cyp1a2 Cyp4a8 Cyp2c6v1 KERATAN SULFATE KERATIN METABOLISM%REACTOME DATABASE ID RELEASE 66%10145729 Keratan sulfate keratin metabolism Hexb Kera Hexa Lum Prelp Chst5 LOC100911750 Chst2 Chst1 B3gnt4 B3gnt7 B3gnt1 B3gnt2 B3gnt3 Fmod Acan Omd Glb1l LOC100910891 B4galt1 Ogn B4galt3 Slc35d2 B4galt2 Glb1 B4galt6 St3gal2 B4galt4 St3gal3 B4galt5 St3gal1 St3gal4 St3gal6 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A%REACTOME DATABASE ID RELEASE 66%10145216 Cdc20:Phospho-APC C mediated degradation of Cyclin A Psmc6 Psmb10 Psmb8 Psmb9 Psmb4 Psmb11 Bub3 Psmb5 Psmf1 Psmb6 Psmd4 Psmb2 Psmd5 Psmd8 Psmd9 Psmb3 Psma8 Psmd11 Psmd12 Anapc11 Ccna2 Ccna1 Anapc15 Psmd13 Anapc10 Psmd14 Psmc3 G6pc Ube2d1 Cdc20 Psmb7 Psmb1 Bub1b Mad2l1 Anapc7 Cdc26 Cdc27 Cdc23 Psma5 Ube2c Cdk1 Anapc16 Cdc16 Anapc4 Psma2 Anapc2 Anapc1 Psmc5 Psmd2 Psma1 Psma4 Psmc1 Psma3 Psmc4 Psmc2 Psma6 Psme1 Psmd1 Psme2 Psmd7 Psmd3 Psmd6 LDL CLEARANCE%REACTOME%R-RNO-8964038.1 LDL clearance Ap2a2 Pcsk9 Npc1 Nceh1 Lipa Soat1 Soat2 Cltc Ldlr Clta Apob Ap2s1 Ldlrap1 Ap2a1 Ap2m1 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX%REACTOME%R-RNO-445989.1 TAK1 activates NFkB by phosphorylation and activation of IKKs complex Ripk2 Ager Nfkbib Traf6 App Tab1 Rela Map3k7 Irak2 Nfkb2 Nfkb1 S100b Dhx9 Chuk Nkiras1 LOC100362142 Nod1 Nod2 Nfkbia Nkiras2 LOC100910771 Ube2n Tab2 Tab3 LOC100912618 Ube2v1 Ikbkb Myd88 CHEMOKINE RECEPTORS BIND CHEMOKINES%REACTOME%R-RNO-380108.1 Chemokine receptors bind chemokines Ccl21 Ccr6 Ccr5 Pf4 Ccr4 Ccr3 Ccl27 Ccl20 Ccl25 Cxcl12 Xcr1 Cxcl16 Ccr10 Cx3cr1 Ccl19 Ccr7 Ackr4 Ccr8 Ackr3 Cxcr3 Cxcl10 Cxcr4 Xcl1 Ccr9 Cxcl9 Cxcl11 Cxcl6 Cx3cl1 Cxcl2 Cxcl1 Cxcl3 Ccl5 Ppbp Cxcr5 Ccrl2 Cxcr6 Cxcr2 Ccl1 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL%REACTOME%R-RNO-198323.1 AKT phosphorylates targets in the cytosol Akt3 Mdm2 Cdkn1a Akt1s1 Cdkn1b Chuk Tsc2 Akt1 Akt2 Casp9 PROCESSING OF DNA DOUBLE-STRAND BREAK ENDS%REACTOME DATABASE ID RELEASE 66%10146130 Processing of DNA double-strand break ends Rhno1 Rfc2 Bard1 Wrn Topbp1 Rbbp8 Rmi1 Rmi2 Hus1 Rad50 Ppp4r2 Ppp4c Rpa1 Rpa2 Ccna2 Ccna1 Atm Atrip Cdk2 Rpa3 Rad1 Brca1 Atr Blm Rad17 Slc25a16 Sirt6 Rfc5 Rfc4 Rad9a Nbn Rfc3 Rad9b Mre11a CARGO TRAFFICKING TO THE PERICILIARY MEMBRANE%REACTOME DATABASE ID RELEASE 66%10146079 Cargo trafficking to the periciliary membrane Arf4 Sstr3 Inpp5e Bbs7 Bbs5 Bbs4 Rab8a Gbf1 Exoc3 Exoc2 Exoc1 Exoc6 Exoc5 Exoc8 Exoc7 Ttc8 Pde6d Bbs9 Bbs1 Bbs2 Rab11a Smo Mchr1 Arl6 Rab3ip Lztfl1 Pkd2 Pkd1 Cnga4 Cnga2 Cngb1 Arl13b GLYCEROPHOSPHOLIPID BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 66%10144908 Glycerophospholipid biosynthesis Pla2g6 Pla2g3 Pla2g5 Pitpnb Pla2g16 Pla2g15 Pla2g10 Csnk2a2 LOC103689982 Osbpl5 Cpne3 Pla2g12a Osbpl8 Csnk2a1 Stard7 Fam73b Awat2 Lpcat4 Alpp Lpcat1 Alpi Plbd1 Abhd4 Lipi Cpne6 Acp6 Lpcat3 Lpcat2 Cpne1 Cpne7 Gnpat Agk Abhd3 Tmem86b Lclat1 Bche Pla2g4cl1 Chat Etnppl Ache Cept1 Pld2 Pld6 Alppl2 Dgat2l6 Agpat1 Agpat4 Ptdss2 Agpat3 Cdipt Pnpla8 Agpat9 Dgat1 Agpat6 LOC317456 Agpat5 Etnk1 Osbpl10 Pnpla3 Gpam Pnpla2 Crls1 Lpin2 Lpin3 Lpin1 Dgat2 Gpat2 Gpd2 Cds2 Ddhd2 Ddhd1 Pla2r1 Slc44a4 Pld1 Pla2g4e Slc44a5 Pla2g4b Mboat1 Pla2g4d Slc44a3 Mboat7 Pctp Pla2g4a LOC100910990 Cds1 Pla2g4c Taz Mgll Hrasls5 Slc44a2 Pcyt1b Pcyt1a Pitpnm1 Pitpnm3 Pitpnm2 Rbm12 Stard10 Pcyt2 Pla2g2a Pla2g2f Pla2g2d Gpd1l Pla2g1b LOC686302 LOC100911615 Chka Mfsd2a Csnk2b Phospho1 Lpgat1 Hadha Hadhb Gpd1 Agpat2 Pemt NEUROPHILIN INTERACTIONS WITH VEGF AND VEGFR%REACTOME%R-RNO-194306.1 Neurophilin interactions with VEGF and VEGFR LOC100911280 Kdr Flt1 Nrp1 Nrp2 DNA REPLICATION PRE-INITIATION%REACTOME DATABASE ID RELEASE 66%10144714 DNA Replication Pre-Initiation Psmc6 Psmb10 Psmb8 Pole2 Psmb9 Pole4 Psmb4 Psmb11 Psmb5 Psmf1 Psmb6 Psmd4 Psmb2 Psmd5 Psmd8 Psmd9 Psmb3 Psma8 Psmd11 Psmd12 Prim2 Pola2 Psmd13 Psmd14 Prim1 Mcm2 Mcm4 Mcm3 Cdk2 Mcm5 Rpa3 Mcm6 Pole Mcm10 Psmc3 Mcm8 Mcm7 Orc4 Orc5 Orc6 Orc1 Orc2 Orc3 Cdc7 Cdc6 Cdc45 Gmnn G6pc E2f2 Psmb7 Psmb1 Rpa1 Rpa2 E2f1 Psma5 E2f3 Cdt1 Psma2 Psmc5 Psmd2 Psma1 Psma4 Psmc1 Psma3 Psmc4 Psmc2 Psma6 Psme1 Psmd1 Psme2 Psmd7 Psmd3 Psmd6 PRESYNAPTIC FUNCTION OF KAINATE RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145706 Presynaptic function of Kainate receptors Plcb1 Grik3 Gnb3 Gnb5 Plcb3 Gnb2 Gnb1 Gng13 Gng12 Gng11 LOC100912034 Gnb4 Gng4 Gngt2 Gng5 Gngt1 Gng10 Gng8 Gng3 NADPH REGENERATION%REACTOME DATABASE ID RELEASE 66%10145547 NADPH regeneration Idh1 KERATAN SULFATE DEGRADATION%REACTOME%R-RNO-2022857.1 Keratan sulfate degradation Prelp Ogn Glb1 Hexb Kera Hexa Omd Glb1l Lum LOC100910891 Acan Fmod BIOSYNTHESIS OF D-SERIES RESOLVINS%REACTOME DATABASE ID RELEASE 66%10146303 Biosynthesis of D-series resolvins Hpgd Gpx4 Alox5 Lta4h AMPLIFICATION OF SIGNAL FROM THE KINETOCHORES%REACTOME%R-RNO-141424.1 Amplification of signal from the kinetochores Cenpn Zwilch Cenpl Nup43 Cenpo Nup98 Nup133 Dync1li2 Nup107 Cenpt Cenpu Bub3 Bub1 Spdl1 Kntc1 Dync1i2 Mad1l1 Cenpk Cenph Nup37 Cenpi Cenpf Cenpe Cenpm Ahctf1 Ndel1 Cdca8 Dync1h1 Rcc2 Pafah1b1 Dync1li1 Rangap1 Mis12 Ppp1cc LOC100909468 Aurkb Dynll2 Ndc80 Sec13 Cenpc Xpo1 Cenpa Dync1i1 LOC100911204 Ranbp2 Spc24 Spc25 Birc5 Taok1 Itgb3bp Sgol2 Ppp2r5e Incenp Nsl1 B9d2 Cdc20 Kif2a Kif2c Kif2b Bub1b Kif18a Ppp2r5c Ppp2cb Ppp2r5a Ppp2ca Ppp2r1a Ppp2r5b Zwint Dsn1 Mad2l1 Nup85 Casc5 Clasp2 Ercc6l Nuf2 Clasp1 LOC679582 Ppp2r1b Mapre1 Pmf1 Ckap5 Ska2 Sgol1 Zw10 Ska1 REGULATION OF INSULIN SECRETION%REACTOME DATABASE ID RELEASE 66%10145114 Regulation of insulin secretion Plcb1 Cacna1e Slc25a5 Marcks Plcb3 Ffar1 Gnaq Gna11 Gna14 Gna15 Adcy5 Adcy6 Kcnj11 Abcc8 Gng10 Cacna1c Cacna1d Slc2a2 Adra2a Gnai2 Adra2c Gnb3 Rap1a Gnb5 Kcnc2 Gnb2 Gnb1 Gng13 Gng12 Gng11 Prkaca Prkacb Itpr1 Cacnb2 Kcns3 Rapgef4 Itpr3 Prkca LOC100912034 Slc2a1 Gnb4 Glp1r Gcg Cacna2d2 Gng4 Gngt2 Gnai1 Gng5 Gngt1 Gng8 Gng3 INTERLEUKIN-23 SIGNALING%REACTOME%R-RNO-9020933.1 Interleukin-23 signaling Il12rb1 P4hb Il23a Il12b Stat3 Il23r Tyk2 CALCINEURIN ACTIVATES NFAT%REACTOME DATABASE ID RELEASE 66%10145926 Calcineurin activates NFAT RGD1560225 Ppp3ca Nfatc2 Ppp3r1 Nfatc3 RNA POLYMERASE I TRANSCRIPTION%REACTOME%R-RNO-73864.1 RNA Polymerase I Transcription Gtf2h1 Gtf2h2 Mnat1 RGD1565904 Ubtf Polr1b Taf1d Taf1c Polr2h Cd3eap Polr2e Znrd1 Polr2f Polr1c Polr2k Polr1a Ptrf Ttf1 Hist1h2bo Hist1h2bcl1 Hist2h3c2 LOC100912534 Rrn3 Hist1h2bk H3f3b Hdac2 Mbd3 Hdac1l Chd3 Chd4 Ccnh Mta3 Gtf2h3 Mta1 Mta2 Gatad2a Gtf2h5 Tbp Gtf2h4 Gatad2b LOC100910200 H2afx Hist1h4b LOC684841 Hist1h2bh LOC100912290 Rbbp7 Hist1h2ail1 Hist1h4m LOC102549173 LOC103690002 Ehmt2 LOC100910152 LOC100912338 Hist1h3c Hdac1 Ercc3 H2afb3 Hist1h3f Ercc6 Hist2h4 LOC684819 Hist1h3a H2afj Hist2h2aa3 Hist1h2bq Hist2h2aa2 Ercc2 LOC100364835 LOC684762 Cdk7 Twistnb Polr1e Hist1h2bg Mbd2 LOC680097 LOC684797 LOC100912418 Hist1h2ba Hist3h2bb LOC100910121 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS%REACTOME%R-RNO-75876.1 Synthesis of very long-chain fatty acyl-CoAs Acsl1 Acsl6 Acsl5 Acsl4 Tecr Hacd1 Tecrl LOC100365676 Hsd17b3 Acsbg1 Elovl1 Elovl5 Elovl2 Elovl3 Acsf3 Hacd4 Hacd3 Elovl6 Hsd17b12 Acsbg2 Acsl3 REGULATION OF COMPLEMENT CASCADE%REACTOME%R-RNO-977606.1 Regulation of Complement cascade C1s Elane C1r C1qb C4a C1qa C4b LOC100909666 LOC102549354 C2 Vtn C5ar1 Cd59 Cpn1 Cpn2 Cr2 Cpb2 Clu C5ar2 Cd46 Serping1 C6 Cfhr1 Cd19 C8g C3 RGD1564614 Cd81 C8a C8b Cfh F2 C3ar1 MTORC1-MEDIATED SIGNALLING%REACTOME%R-RNO-166208.1 mTORC1-mediated signalling LOC100912571 Eif4ebp1 Akt1s1 LOC100911431 Eef2k RragB Eif4g1 Lamtor3 Ywhab Eif4b Rps6kb1 Mtor Rheb Lamtor2 Rptor Lamtor1 Lamtor4 Lamtor5 Mlst8 LOC100911372 Rraga Rragc Rragd Rps6 Slc38a9 LOC680559 METABOLISM OF POLYAMINES%REACTOME%R-RNO-351202.1 Metabolism of polyamines Slc6a11 Smox Nqo1 Psmc6 Oaz3 Sat1 Slc6a12 RGD1564480 Psmb10 Oaz1 Oaz2 Psmb8 Psmb9 Psmb4 Psmb11 Psmb5 Psmf1 Psmb6 Psmd4 Psmb2 Psmd5 Psmd8 Psmd9 Psmb3 Azin1 Psma8 Psmd11 Psmd12 Slc6a7 Psmd13 Psmd14 Nmral1 Ass1 Nags Cps1 Slc25a2 Psmc3 Paox G6pc Otc Arg1 Psmb7 Psmb1 Agmat Psma5 Ckb Sms Enoph1 LOC100912604 Mtap Ckmt1b Mri1 Amd1 Gamt Adi1 Psma2 LOC100364487 Srm Psmc5 Psmd2 Psma1 Psma4 Psmc1 Psma3 Psmc4 Psmc2 Psma6 Psme1 Odc1 Psmd1 Psme2 Psmd7 Psmd3 Psmd6 G2 M CHECKPOINTS%REACTOME DATABASE ID RELEASE 66%10144759 G2 M Checkpoints Rhno1 Bard1 Psmc6 Rfc2 Wrn Topbp1 Psmb10 Rbbp8 Rmi1 Rmi2 Psmb8 Psmb9 Psmb4 Psmb11 Psmb5 Psmf1 Psmb6 Rad50 Bre Psmd4 Psmb2 Psmd5 Psmd8 Psmd9 Psmb3 Brcc3 Psma8 Psmd11 Psmd12 Pias4 Psmd13 Psmd14 Uimc1 Atm Mcm2 Atrip Mcm4 Mcm3 Cdk2 Mcm5 Sumo1 Clspn Rpa3 Mcm6 Mcm10 Rad1 Psmc3 Brca1 Atr Blm Mcm8 Mdc1 Mcm7 Ube2v2 Rad17 Orc4 Orc5 Ube2n Orc6 Orc1 Orc2 Orc3 Cdc7 Rfc5 Rad9a Rfc4 Cdc6 Rfc3 Nbn Rad9b Mre11a Cdc45 Hus1 Babam1 Tp53bp1 Herc2 Rpa1 Ywhah Rpa2 Ywhag Sfn Ywhaz Ywhab Ywhaq Ywhae Slc25a16 Hist1h2bo Hist1h2bcl1 Hist1h2bk Cdc25c Whsc1 LOC100910200 H2afx Hist1h4b Rnf8 G6pc Hist1h2bh LOC100912290 LOC686349 Hist1h4m Psmb7 LOC100912338 Psmb1 Hist2h4 Hist1h2bq LOC100364835 Psma5 Fam175a LOC100910954 Cdk1 Chek2 Psma2 Psmc5 Gtse1 Psma1 Psmd2 Psma4 Psmc1 Psma3 Wee1 Psmc4 Pkmyt1 Psma6 Psmc2 Psme1 Hist1h2bg Psme2 Psmd1 Psmd7 LOC680097 LOC684797 LOC100912418 Hist1h2ba Hist3h2bb Psmd3 Psmd6 ORGANIC CATION TRANSPORT%REACTOME%R-RNO-549127.1 Organic cation transport Slc22a1 Slc22a15 Slc22a2 Slc22a3 Runx1 Slc22a5 TRANSCRIPTIONAL ACTIVATION OF P53 RESPONSIVE GENES%REACTOME DATABASE ID RELEASE 66%10146178 Transcriptional activation of p53 responsive genes Zfp385a LOC100910954 CREATION OF C4 AND C2 ACTIVATORS%REACTOME DATABASE ID RELEASE 66%10145209 Creation of C4 and C2 activators C1s C1r Masp2 C1qb Colec10 C1qa Colec11 GLUCOSE METABOLISM%REACTOME%R-RNO-70326.1 Glucose metabolism Nup93 Nup43 Nup98 Nup133 LOC100911625 Mdh2 Nup107 Mdh1 Eno3 Aaas Gapdhs Eno1 Eno2 Nup210 Aldoa Npap60 Got1 Fbp1 Nup35 Aldob Fbp2 Aldoc Nup37 Nupl2 Gckr Nupl1 Pklr Pc Got2 Pfkfb3 Pfkfb4 Pfkfb1 Pfkfb2 Pfkl Pfkp Nup205 Aldoart2 Ranbp2 Slc25a11 Slc25a10 Hk2 Pgm2l1 G6pc Nup155 Tpi1 Gpi Nup88 Slc25a1 Nup85 Pgk2 G6pc3 Pgk1 Nup153 Slc37a2 Pkm Tpr Pgam1 Pgam2 Rae1 Gnpda2 Adpgk Pck1 Nup54 Pom121 Bpgm Nup62 Slc37a1 INTERLEUKIN-27 SIGNALING%REACTOME%R-RNO-9020956.1 Interleukin-27 signaling Canx Stat1 Crlf1 Il6st Jak1 Stat3 Tyk2 Ebi3 Il27ra TRANSCRIPTIONAL REGULATION BY THE AP-2 (TFAP2) FAMILY OF TRANSCRIPTION FACTORS%REACTOME%R-RNO-8864260.1 Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors Cited1 Atad2 Sumo1 Tfap2b Tfap2c Bmyc Cited2 Tfap2d Tfap2a Tfap2e Lhb Esr1 Cited4 Yeats4 Ube2i Crebbp Cga Dek TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION)%REACTOME%R-RNO-2173791.1 TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) Arhgef18 Pard6a Rhoa Smurf1 Tgfbr1 Pard3 Tgfb1 F11r Prkcz Tgfbr2 Cgn NEGATIVE REGULATION OF TCF-DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS%REACTOME DATABASE ID RELEASE 66%10146021 Negative regulation of TCF-dependent signaling by WNT ligand antagonists Lrp5 Lrp6 Dkk1 Kremen2 Sost Dkk2 Dkk4 BETA OXIDATION OF OCTANOYL-COA TO HEXANOYL-COA%REACTOME DATABASE ID RELEASE 66%10144937 Beta oxidation of octanoyl-CoA to hexanoyl-CoA LOC100911186 Echs1 Hadh Hadha Hadhb Acadm RAB REGULATION OF TRAFFICKING%REACTOME DATABASE ID RELEASE 66%10146223 Rab regulation of trafficking Trappc10 Rabgap1 Madd Sbf1 Rin3 Rab35 Rab18 Rgp1 Rab8a Ulk1 Sbf2 Rab10 Rab14 Rab27a Trappc2l Gapvd1 Rab21 Dennd3 Tbc1d10a Trappc6a Trappc6b Tbc1d10b Arf6 Rab12 Rab3ip Rab13 LOC102555167 Hps4 Rab32 Gdi2 Rab39a Hps1 Mon1b Mon1a Rab38 Rab11b Rab1b Rab1a Tbc1d2 Dennd1a Tbc1d7 Gabarap Trappc12 Trappc11 Akt2 Rab4a Dennd1b Trappc2 Trappc5 Rab6b Rab9a Rab27b Ric1 Rab3a Akt1 Ccz1b St5 Rab7a Rab3gap2 Dennd6b Dennd6a Ywhae Trappc3 Rab8b Dennd5a LOC100910318 Gabarapl2 Rab3il1 Tsc1 Chm Trappc8 Rab11a Dennd4a Rab6a Dennd4b Tsc2 Rab7b Tbc1d13 Akt3 Tbc1d16 Tbc1d15 Tbc1d17 Sytl1 Dennd2a Rab33a Dennd2d Rab33b Dennd2c Trappc13 Tbc1d25 Rab9b Optn Tbc1d10c LOC100363782 Trappc1 Tbc1d14 NEUREXINS AND NEUROLIGINS%REACTOME%R-RNO-6794361.1 Neurexins and neuroligins Dlgap2 Dlgap3 Dlgap4 Grm1 Epb4.1l5 Lrrtm2 Lrrtm3 Lrrtm4 LRRTM1 Dlg2 Dlg3 Dlgap1 Epb4.1 Nrxn2 Shank1 Shank2 Dbnl Nlgn1 Homer3 Nlgn2 Nlgn3 Homer2 Homer1 Dlg4 Epb41l2 Epb41l3 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS%REACTOME%R-RNO-2029480.1 Fcgamma receptor (FCGR) dependent phagocytosis Pla2g6 Pld1 Abi1 Myo1c Abi2 Potef Rac1 Myh9 Nck1 Arpc1b LOC100909750 Cyfip1 Actb Fyn Brk1 Pld4 Ppapdc1a LOC103692716 Pld3 Baiap2 Limk1 Nf2 Ppapdc1b Pak1 Wasl Nckap1l Ptk2 Actg1 Cyfip2 Nckap1 Abl1 Fcgr3a Prkcd Wasf1 Arpc4 Src LOC100909609 Pik3r1 Pld2 Pik3r2 Arpc3 Hsp90ab1 Nckipsd LOC100361457 Myo9b Vav2 Vav1 Actr3 Fcgr1a Was Cd247 Actr2 Fgr Myo10 Vav3 Crk Mapk1 Cdc42 LOC100911597 Pik3cb Cd3g Arpc5 Plcg1 Lyn Dock1 Fcgr2b Wipf1 LOC103693683 Yes1 Wipf2 Elmo2 Wipf3 Hck Fcgr2a Syk Grb2 ENDOGENOUS STEROLS%REACTOME DATABASE ID RELEASE 66%10145314 Endogenous sterols Nr1h4 Cyp1b1 Cyp39a1 Pomc Ptgis Ncoa2 Cyp7a1 Arnt Cyp21a1 Rxra Fdxr Cyp51 Cyp46a1 Fdx1 Cyp8b1 Arnt2 Cyp19a1 Fdx1l Cyp4v3 Cyp7b1 Ncoa1 Ahr Cyp11b2 SPRY REGULATION OF FGF SIGNALING%REACTOME DATABASE ID RELEASE 66%10145760 Spry regulation of FGF signaling Mknk1 Ptpn11 Src Ppp2cb Ppp2ca Ppp2r1a Cbl Spry2 Mapk1 Grb2 ER-PHAGOSOME PATHWAY%REACTOME DATABASE ID RELEASE 66%10145816 ER-Phagosome pathway RT1-CE2 RT1-CE3 RT1-CE4 RT1-CE7 RT1-CE5 RT1-CE10 RT1-A Calr RT1-A2 RT1-M3-1 RT1-A1 Sec22b Tap1 B2m Tap2 RT1-M6-1 LOC683761 LOC100364956 Vamp8 RT1-M2 RT1-M6-2 LOC100364500 RT1-M5 RT1-M4 Tapbp Stx4 RT1-S3 Vamp3 OTHER SEMAPHORIN INTERACTIONS%REACTOME%R-RNO-416700.1 Other semaphorin interactions Trem2 Ptprc Plxna1 Sema4d Sema7a Tyrobp Cd72 Plxnd1 Sema6d Sema3e Sema5a SIGNALING BY BMP%REACTOME DATABASE ID RELEASE 66%10145385 Signaling by BMP Fstl1 Grem2 Amhr2 Smurf1 Cer1 Nog Ube2d1 Acvrl1 Bmp2 Amh Acvr2a Chrdl1 Smad9 Smad5 Smad6 Ube2d3 Gdf2 Bmpr2 Zfyve16 NEGATIVE REGULATION OF FGFR2 SIGNALING%REACTOME DATABASE ID RELEASE 66%10145762 Negative regulation of FGFR2 signaling Src Fgf23 Fgf22 Fgf4 Fgf1 Fgf3 Ppp2cb Ppp2ca Fgf6 Fgf5 Ppp2r1a Fgf20 Mknk1 Fgf16 Fgf17 Fgf10 Fgf9 Fgfr2 Fgf7 Fgf2 Fgf8 Spry2 Cbl Mapk1 Ptpn11 Frs2 Grb2 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF)%REACTOME DATABASE ID RELEASE 66%10145896 Regulation of cholesterol biosynthesis by SREBP (SREBF) Kpnb1 Mbtps1 Mbtps2 RGD1306195 Srebf1 Scap Srebf2 APOPTOSIS%REACTOME DATABASE ID RELEASE 66%10144862 Apoptosis Faslg Appl1 Kpnb1 Cflar Fadd Apc Dsg3 Dsg2 Sptan1 Dffa Kpna1 LOC100911856 Diablo Casp3 Hmgb2 RGD1559962 Ripk1 LOC100360940 Tradd Tnfsf10 Fas Clspn Prkcq Dnm1l Plec Dynll2 Vim Nmt1 Fnta Ptk2 Satb1 Gzmbl1 Prkcd Bmx Gzmc LOC100911163 Gzmbl2 Rock1 Birc2 Gzmbl3 Bak1 Dcc Lmna Gzmb LOC691695 Ywhah Mapt Bcl2l11 Ywhag Casp6 Stk26 Sfn Add1 Stk24 Ywhaz Acin1 Ppp3r1 Bcl2 Gas2 Ocln Bid Ywhab Xiap Tjp2 Bcap31 Ywhaq Ywhae Dsp Cdh1 Casp8 Bad Dsg1 Casp9 Mapk8 Gsn Lmnb1 Pkp1 Traf2 Bax Oma1 Dbnl Opa1 Bmf Pmaip1 DERMATAN SULFATE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 66%10145924 Dermatan sulfate biosynthesis Bcan Ncan Vcan LOC102550316 Cspg5 Dse Cspg4 LOC100910284 Ust Dcn Chst14 Dsel CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION%REACTOME DATABASE ID RELEASE 66%10144735 Cyclin E associated events during G1 S transition Psmc6 Psmb10 Psmb8 Psmb9 Psmb4 Psmb5 Psmf1 Psmb6 Psmd4 Mnat1 Psmb2 Cul1 Psmd5 Ptk6 Psmd8 Psmd9 Psmb3 Psmd11 Psmd12 Ccna2 Ccne2 Ccna1 Psmd13 Psmd14 Ccne1 Cdk2 Cks1l Cables1 Psmc3 Ccnh Cks1b Akt2 G6pc Rb1 Cdk4 Akt1 Psmb7 Psmb1 Ccnd1 Skp1 Psma5 Skp2 Cdkn1a Cdk7 Cdkn1b Psma2 Psmc5 Akt3 Psmd2 Psma1 Psma4 Psmc1 Cdc25a Wee1 Psma3 Psmc4 Psmc2 Psma6 Psme1 Psmd1 Psme2 Psmd7 Psmd3 Psmd6 BIOGENIC AMINES ARE OXIDATIVELY DEAMINATED TO ALDEHYDES BY MAOA AND MAOB%REACTOME DATABASE ID RELEASE 66%10145055 Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB Maob Maoa TNF SIGNALING%REACTOME%R-RNO-75893.1 TNF signaling Nsmaf Usp21 Fadd Birc3 Birc2 Adam17 Cyld Otud7b Madd Tax1bp1 Sppl2a Tab1 Clip3 Ripk1 Otulin Tradd Tnf Xiap Map3k7 Casp8 Tnfaip3 Rnf31 Sharpin Usp2 Traf1 Bag4 Rbck1 Smpd2 Smpd3 Chuk Traf2 Usp4 LOC100910771 Tab2 Tab3 Ikbkb DIGESTION OF DIETARY CARBOHYDRATE%REACTOME%R-RNO-189085.1 Digestion of dietary carbohydrate Amy2a3 Chia RGD1309110 Chit1 Amy1a Lct Si Chi3l3 PLATELET DEGRANULATION%REACTOME DATABASE ID RELEASE 66%10145469 Platelet degranulation Tex264 F13a1 Ola1 Psap Ly6g6f Ctsw Selp Serpina4 Pcyox1l Tor4a Islr Cdc37l1 Chid1 Fam3c Lhfpl2 Nhlrc2 Itih4 Mmrn1 Rarres2 Itih3 Lefty2 Ecm1 Serpine1 Anxa5 Tagln2 Gtpbp2 Timp3 Lefty1 LOC100910414 Lamp2 Plek Sccpdh Phactr2 Cfd Cd9 Kng1l1 A1bg Tgfb2 F8 Tgfb1 Tgfb3 Pf4 Aplp2 Cd109 Figf Rab27b Vegfc Vegfb Brpf3 Apoa1 Pdgfa Pdgfb Timp1 Abcc4 A2m Tln1 Vwf Actn4 Vegfa Habp4 Pcdh7 Apool Apoh Plg Wdr1 Srgn LOC100911881 Lgals3bp Sytl4 LOC100912012 Serpina3m Fermt3 Cyb5r1 Maged2 Vcl Sparc Sod1 Actn2 Gas6 Aldoa App Tf Flna Igf2 Igf1 Clu Serping1 Cd63 Fgb RGD1565355 Fgg Hgf Thbs1 Fga Aldoart2 Actn1 Qsox1 LOC685953 Cd36 Scg3 Stxbp2 Kng1 LOC299277 Kng2 Fn1 Ppbp Tuba4a Pros1 Itga2b PROGRAMMED CELL DEATH%REACTOME%R-RNO-5357801.1 Programmed Cell Death Faslg Appl1 Kpnb1 Cflar Fadd Apc Dsg3 Dsg2 Mlkl Sptan1 Ripk3 Dffa Kpna1 LOC100911856 Diablo Casp3 Hmgb2 RGD1559962 Ripk1 LOC100360940 Tradd Tnfsf10 Fas Clspn Prkcq Dnm1l Plec Dynll2 Vim Nmt1 Fnta Ptk2 Satb1 Gzmbl1 Prkcd Bmx Gzmc LOC100911163 Gzmbl2 Rock1 Birc3 Birc2 Gzmbl3 Bak1 Dcc Lmna Gzmb LOC691695 Ywhah Mapt Bcl2l11 Ywhag Casp6 Stk26 Sfn Add1 Stk24 Ywhaz Acin1 Ppp3r1 Bcl2 Gas2 Ocln Bid Ywhab Xiap Tjp2 Bcap31 Ywhaq Ywhae Dsp Cdh1 Casp8 Bad Dsg1 Casp9 Mapk8 Gsn Lmnb1 Pkp1 Traf2 Bax Oma1 Dbnl Opa1 Bmf Pmaip1 SIGNALING BY NOTCH2%REACTOME DATABASE ID RELEASE 66%10145921 Signaling by NOTCH2 Notch2 Mdk Dll4 Maml1 Rbpj Rbpjl2 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS)%REACTOME DATABASE ID RELEASE 66%10145487 Class A 1 (Rhodopsin-like receptors) Gpr39 Ffar1 Ptgir Kng1l1 Cmklr1 Gpr35 Ccr6 Pomc Chrm4 Oxtr Oxt LOC100909648 Avpr1b Avpr1a Opn1sw Oprl1 Ccl21 Prokr2 Mc3r Ccr5 Gal Ccr4 Ccr3 Gpr37 Ccl27 Cckar Gper1 Ccl20 Uts2r Prokr1 Ccl25 NMS Xcr1 Cxcl16 Pdyn Prlhr Ccr10 Gpr37l1 Ccl19 Ccr7 Ccr8 Cxcr3 Cxcl10 Ccr9 Opn1mw Cxcl11 Ece2 Ece1 Xk Sstr5 Brs3 Npbwr1 Pyy C5ar2 Pnoc Ccl5 Npy2r Mc4r Prok2 Oprm1 Prok1 Mchr1 Sstr1 Aplnr Sstr4 Sstr2 Cck Npy1r Apln Tacr3 Tacr2 Bdkrb1 Bdkrb2 Rln3 Npb Ppy Trh Ccl1 Npw Mc2r Npy Nps Adra1a Tbxa2r Sstr3 Penk Adra1d C5ar1 Kng1 Kng2 Gphb5 Gnrhr Gpha2 Gnrh1 Htr4 Fshr Tshr Cxcr5 Htr7 Uts2b Npy5r Nmur2 Cxcr6 Oprd1 Lhcgr LOC100909513 LOC100360745 Htr6 Npff Npffr2 RGD1560028 Psap Hcrt Npffr1 Qrfp LOC100909783 Lhb Oxgr1 Ptgdr Ptgdr2 Sucnr1 Adra2b Adrb3 F2rl3 Hcrtr1 F2r Qrfpr Cxcr2 F2 Hcrtr2 Ptger2 Tshb Cga F2rl2 Hebp1 Uts2 Fpr-rs6 Ntsr2 Trhr Nmu Fpr-rs3 Pf4 Mc5r Fpr2 Fpr3 Ntsr1 Anxa1 Pmch Rxfp1 Htr2c Rxfp2 Htr2a Kel Fpr-rs4 Insl3 Tac3 Kiss1 Rxfp3 Tac1 Htr2b Lpar5 Edn2 S1pr1 Ednra S1pr5 Ptafr Ednrb S1pr4 Edn3 Grp S1pr3 Grpr Lpar1 Cx3cr1 Lpar3 Edn1 Lpar2 F2rl1 Sst Ackr4 S1pr2 Ackr3 Nmb Xcl1 Cxcl9 Cxcl6 Cx3cl1 Gpr31 Cxcl2 Taar9 Rgr Cxcl1 Gpr18 Gpr55 Gpr4 Hrh2 Htr5a Fshb Taar6 Cxcl3 Agt Gpr132 Taar5 Cnr2 Gpr143 Taar2 Opn3 Lppr1 Opn4 Cnr1 Lppr4 Htr1d Lppr5 Htr1f Lppr2 Htr1a Hrh1 Lppr3 Htr1b Hrh4 Chrm1 Ptger3 Chrm5 Adora3 Agtr2 Gpr183 Prlh Mtnr1a Opn5 Galr1 LOC100909523 Ccrl2 Hcar1 Nts Hcar2 Oprk1 Cysltr2 Adora2a Drd5 Cysltr1 Adora2b Drd1 Gpr65 Gpr68 LOC100911796 Drd4 Ptgfr LOC100363178 Drd2 Adora1 Ptger1 LOC100365814 Chrm3 Agtr1b Agtr1a Fpr1 Chrm2 Ltb4r Ffar2 Ffar3 Ltb4r2 Avp C3ar1 P2ry6 Lpar6 P2ry4 P2ry1 Gpr17 Lpar4 Ptgdrl Cxcl12 P2ry12 Cxcr4 P2ry2 P2ry10 P2ry13 Adra2a Adra2c C3 Ppbp Cckbr Adrb2 Tacr1 TELOMERE C-STRAND SYNTHESIS INITIATION%REACTOME DATABASE ID RELEASE 66%10145233 Telomere C-strand synthesis initiation Pole2 Pole4 Prim2 Pola2 Pole Prim1 DCC MEDIATED ATTRACTIVE SIGNALING%REACTOME%R-RNO-418885.1 DCC mediated attractive signaling Nck1 Src Fyn LOC100909609 Wasl Dock1 Ntn1 Ptk2 Dcc Rac1 Cdc42 THE FATTY ACID CYCLING MODEL%REACTOME DATABASE ID RELEASE 66%10145135 The fatty acid cycling model Ucp2 Ucp3 LOC100909612 Slc25a14 Ucp1 SYNTHESIS OF UDP-N-ACETYL-GLUCOSAMINE%REACTOME%R-RNO-446210.1 Synthesis of UDP-N-acetyl-glucosamine Renbp Gfpt2 Amdhd2 Pgm3 Nagk Gfpt1 Gnpnat1 Uap1 HYALURONAN BIOSYNTHESIS AND EXPORT%REACTOME%R-RNO-2142850.1 Hyaluronan biosynthesis and export Has1 Has2 Cemip SMOOTH MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 66%10145669 Smooth Muscle Contraction Dysf Myl10 Cav3 Myl7 Myh11 Tln1 Actg2 Pxn Sorbs3 Cald1 Trim72 Vcl Sorbs1 LOC102551071 Mylpf Pak2 Pak1 Tpm4 Tpm2 Mylk Tpm3 Myl12a DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX%REACTOME%R-RNO-195253.1 Degradation of beta-catenin by the destruction complex Ctbp2 Psmc6 Psmb10 Apc Psmb8 Psmb9 Psmb4 Psmb11 Psmb5 Psmf1 Psmb6 Psmd4 Psmb2 Rbx1 Cul1 Psmd5 Psmd8 Psmd9 Psmb3 Psma8 Psmd11 Psmd12 Psmd13 Psmd14 LOC100909468 Psmc3 Tle3 Peg12 Amer1 Csnk1a1 Frat2 Ppp2r5e G6pc Psmb7 Psmb1 Ppp2r5c Ppp2cb Ppp2r5a Ppp2ca Skp1 Ppp2r1a Ppp2r5b Psma5 Ppp2r1b Btrc Psma2 Psmc5 Psmd2 Psma1 Psma4 Psmc1 Psma3 Psmc4 Psmc2 Psma6 Psme1 Tcf7 Lef1 Psmd1 Psme2 Tcf7l1 Psmd7 Tle4 Tle1 Tle2 Psmd3 Psmd6 POLO-LIKE KINASE MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 66%10145073 Polo-like kinase mediated events Wee1 Pkmyt1 Cdc25c Foxm1 SYNTHESIS OF 12-EICOSATETRAENOIC ACID DERIVATIVES%REACTOME DATABASE ID RELEASE 66%10145948 Synthesis of 12-eicosatetraenoic acid derivatives Alox12 Gpx4 Alox15 Aloxe3 BETAKLOTHO-MEDIATED LIGAND BINDING%REACTOME%R-RNO-1307965.1 betaKlotho-mediated ligand binding Fgf19 Fgfr4 CYCLIN D ASSOCIATED EVENTS IN G1%REACTOME DATABASE ID RELEASE 66%10144736 Cyclin D associated events in G1 Ccnd3 Src Ppp2r3b Rb1 E2f2 Rbl1 Cdk4 Mnat1 Cul1 Ptk6 E2f4 Ppp2cb Ppp2ca Ccnd1 Skp1 Ppp2r1a Tfdp1 Tfdp2 Rbl2 LOC100909750 E2f1 E2f3 Cks1l Skp2 Cdkn1a Cdk7 Cdkn1b Ppp2r1b E2f5 Ccnh Cdkn2b Ppp2r2a Lyn Cdkn2c Cdk6 Cks1b Abl1 DNA DOUBLE-STRAND BREAK REPAIR%REACTOME DATABASE ID RELEASE 66%10144762 DNA Double-Strand Break Repair Rhno1 Rfc1 Rfc2 Bard1 Wrn Topbp1 Rbbp8 Rmi1 Rmi2 Pole2 Rad51c Pole4 LOC100911267 Polh Ppp5c Rad51d Spidr Rad51 Eme2 Eme1 Brca2 Polq Rad50 Rtel1 Bre Ppp4r2 Ppp4c Brcc3 Pias4 Ccna2 Ccna1 Uimc1 Atm Atrip LOC100909750 Cdk2 Sumo1 Rpa3 Lig3 Pole Pcna Xrcc3 Rad1 Brca1 Bap1 Atr Blm Slx4 Mdc1 Mus81 Ube2v2 Slx1b Rad17 Palb2 Sirt6 Ube2n Gen1 Ube2i Rfc5 Xrcc2 Rad9a Rfc4 Rfc3 Nbn Rad9b Mre11a LOC100359600 Hus1 Babam1 Tp53bp1 Rad52 Herc2 Xrcc4 Rpa1 Rpa2 Ercc1 Mapk8 Slc25a16 Fen1 Kpna2 Xrcc6 Xrcc5 Hist1h2bo Hist1h2bcl1 Hist1h2bk Kdm4b Kdm4a Smarca5 Abl1 Whsc1 LOC100910200 H2afx Hist1h4b Rnf8 Hist1h2bh Eya3 LOC100912290 Apbb1 Eya2 LOC686349 Eya4 Hist1h4m LOC100912338 Hist2h4 Hist1h2bq Baz1b LOC100364835 Xrcc1 Fam175a Parp2 Parp1 LOC100910954 Chek2 Pold2 Pold1 Pold4 Tdp2 Lig4 Paxip1 Polm Hist1h2bg Nhej1 Prkdc Dclre1c LOC680097 LOC684797 Poll LOC100912418 Hist1h2ba Hist3h2bb NICOTINATE METABOLISM%REACTOME%R-RNO-196807.1 Nicotinate metabolism Nnmt Nt5e Ptgis Apoa1bp Rnls Carkd Nampt Cd38 Parp14 Nudt12 Nmnat2 Nmnat1 Slc5a8 Nmrk1 Nmrk2 Nadsyn1 Cyp8b1 Parp9 Naprt1 Parp6 Bst1 Parp8 Qprt Ptgs2 Nadk ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS%REACTOME DATABASE ID RELEASE 66%10145788 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Blnk Pik3r1 Dapp1 Cd79al Pik3ap1 Stim1 Cd19 Itpr1 Nck1 Ptpn6 Itpr3 Sh3kbp1 Pik3cd Sos1 Vav1 Cd79b Cd22 Syk Cd79a Grb2 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION)%REACTOME%R-RNO-70614.1 Amino acid synthesis and interconversion (transamination) Serinc4 Psph Rimklb Serinc2 Gpt Serinc3 Srr Aspa Serinc1 Nat8l Naalad2 Folh1 Pycrl Aldh18a1 Got1 Oat Asns Pycr2 Psat1 Pycr1 Phgdh Glul Ccbl1 Got2 TRANSPORT OF ORGANIC ANIONS%REACTOME DATABASE ID RELEASE 66%10145337 Transport of organic anions Slco1a1 Slco4a1 Slco1a6 Slco1a4 Slco3a1 Slco1a2 Slco4c1 Slco2b1 Slco1b2 Slco2a1 Slc16a2 Slc21a4 Slco1c1 Avp NIK-->NONCANONICAL NF-KB SIGNALING%REACTOME DATABASE ID RELEASE 66%10146074 NIK-->noncanonical NF-kB signaling Psmc6 Psmb10 Psmb8 Psmb9 Psmb4 Psmb11 Psmb5 Psmf1 Psmb6 Psmd4 Cul1 Psmb2 Psmd5 Psmd8 Psmd9 Psmb3 Psma8 Psmd11 Psmd12 Psmd13 Psmd14 Ube2m Psmc3 G6pc Psmb7 Psmb1 Skp1 Nfkb2 Psma5 Fbxw11 Chuk Btrc Psma2 Psmc5 Psmd2 Uba3 Psma1 Map3k14 Psma4 Relb Psmc1 Psma3 Psmc4 Psmc2 Psma6 Psme1 Psmd1 Psme2 Psmd7 Psmd3 Psmd6 HISTAMINE RECEPTORS%REACTOME%R-RNO-390650.1 Histamine receptors Hrh4 Hrh2 Hrh1 SHC-MEDIATED CASCADE:FGFR4%REACTOME%R-RNO-5654719.1 SHC-mediated cascade:FGFR4 Kras Fgf16 Fgf17 Fgf9 Fgf2 Fgf8 Fgfr4 Fgf23 Fgf4 Fgf1 Fgf6 Fgf19 Hras Nras Sos1 Shc1 Fgf20 Grb2 APEX1-INDEPENDENT RESOLUTION OF AP SITES VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 66%10146092 APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway Neil1 Ogg1 Neil2 Xrcc1 Lig3 Pnkp Polb UNFOLDED PROTEIN RESPONSE (UPR)%REACTOME DATABASE ID RELEASE 66%10145530 Unfolded Protein Response (UPR) Mbtps1 Eif2ak3 Mbtps2 LOC100363239 Sec61g Ern1 LOC100361694 Creb3l3 Sec63 Crebrf Serp1 Creb3 Sec61a1 Sec62 Sec61a2 Sec61b Atf6 Asna1 Eif2s1 STIMULI-SENSING CHANNELS%REACTOME%R-RNO-2672351.1 Stimuli-sensing channels Scnn1b Best1 Best3 Best2 Trpc4ap Scnn1g Tpcn2 Scnn1a Clcn4 Raf1 Unc79 Sri Slc9b1 Clcn7 Clcn6 Clcn5 Ano10 Wwp1 Ano3 Clic2 Asic4 Asic5 Ano1 Trdn Best4 Clcnkb Asic3 Slc9b2 Trpm2 Slc17a3 Sgk2 Sgk3 Clcn1 LOC100912455 Wnk4 Ostm1 Wnk1 Wnk2 Wnk3 Vps25 Clcn2 Stom Clca4 Fkbp1b Trpv4 Trpv5 Trpv6 Ano9 Ryr2 Ano4 Ano7 Clca2 Sgk1 Stoml3 Mcoln2 Mcoln3 Trpv1 Trpc5 Trpm6 Ttyh1 Ano6 Trpm3 Ttyh2 Trpm8 LOC100361584 Trpm5 Trpc3 Trpc7 Trpm1 Trpc4 Bsnd Mcoln1 Trpc6 Trpv3 Trpa1 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS)%REACTOME DATABASE ID RELEASE 66%10144780 Glycogen breakdown (glycogenolysis) Phkb Phkg1 Gyg1 Pgm2l1 Gaa Agl Pgm2 Pygl Pgm1 Pygm Phkg2 Phka1 B CELL ACTIVATION%REACTOME DATABASE ID RELEASE 66%10145789 B Cell Activation Psmc6 Psmb10 Psmb8 Psmb9 Stim1 Psmb4 Nfkbib Psmb11 Psmb5 Psmf1 Psmb6 Psmd4 Psmb2 Cul1 Psmd5 Psmd8 Psmd9 Psmb3 Nck1 Psma8 Psmd11 Psmd12 Psmd13 Rela Psmd14 Cd22 Cd19 Psmc3 Nfkbia Sh3kbp1 Kras G6pc Pik3r1 Pik3ap1 Psmb7 Psmb1 Skp1 Prkcb Ppp3r1 Pik3cd Vav1 Cd79b Cd79a Nfkbie Nfkb1 Blnk Psma5 Dapp1 Cd79al Fbxw11 Rasgrp1 Chuk Rasgrp3 Btrc Psma2 RGD1560225 Psmc5 Ppp3ca Psma1 Psmd2 Itpr1 Psma4 Nfatc2 Psmc1 Psma3 Itpr3 Ptpn6 Psmc4 Psma6 Psmc2 Psme1 Lyn Hras Psmd1 Psme2 Nras Ikbkb Psmd7 Sos1 Nfatc3 Syk Psmd3 Grb2 Psmd6 PTK6 REGULATES RHO GTPASES, RAS GTPASE AND MAP KINASES%REACTOME DATABASE ID RELEASE 66%10146205 PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases Kras LOC100909609 Crk Pxn Bcar1 Rac1 Arhgap35 Ptk6 Rhoa Dock1 Hras Nras Elmo2 Rasa1 EPH-EPHRIN SIGNALING%REACTOME DATABASE ID RELEASE 66%10146025 EPH-Ephrin signaling Grin2b Grin1 Aph1b Psenen Mmp9 Aph1a LOC100911293 Psen2 Potef Psen1 Rac1 Mmp2 Ncstn Rock2 Sdc2 Arpc1b Actb Fyn Ephb1 Ephb2 Sdcbp LOC103692716 Pak2 Pak3 Pak1 Wasl Ephb4 Ephb3 Efnb2 Ptk2 Efnb1 Actg1 Efnb3 Myl12a Nck2 Arpc4 Arhgef7 Src Rock1 Arpc3 Itsn1 Epha10 Kalrn LOC100361457 LOC100912512 Vav2 Efna2 Actr3 Efna1 Efna4 Actr2 Kdr Tiam1 Vav3 Epha4 Epha5 Ngef Epha7 Cdc42 Epha8 Vegfa Epha3 Epha2 Epha1 Rhoa Arpc5 Lyn Hras Yes1 Rasa1 Shb Arhgef28 TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN CYTOCHROME C RELEASE%REACTOME%R-RNO-6803204.1 TP53 Regulates Transcription of Genes Involved in Cytochrome C Release Prelid1 Bnip3l Zfp420 Triap1 Slmo1 LOC100910137 Atm POLYMERASE SWITCHING%REACTOME DATABASE ID RELEASE 66%10144729 Polymerase switching Rfc1 Rfc2 Prim2 Pola2 Prim1 Rfc5 Rfc4 Pold2 Rfc3 Pcna Pold1 Pold4 PERK REGULATES GENE EXPRESSION%REACTOME DATABASE ID RELEASE 66%10145531 PERK regulates gene expression Eif2ak3 Eif2s1 REGULATION OF RUNX3 EXPRESSION AND ACTIVITY%REACTOME%R-RNO-8941858.1 Regulation of RUNX3 expression and activity Psmc6 Src Psmb10 Mdm2 G6pc Psmb8 Psmb9 Psmb4 Psmb5 Psmf1 Psmb6 Psmd4 Psmb2 Psmd5 Psmd8 Psmb7 Psmd9 Psmb1 Psmb3 Psmd11 Psmd12 Psmd13 Psmd14 Smurf1 Psma5 Psma2 Psmc5 Psmc3 Psma1 Psmd2 Psma4 Psmc1 Cbfb Psma3 Psmc4 Psmc2 Psma6 Psme1 Psmd1 Psme2 Psmd7 Tgfb1 Psmd3 Psmd6 LIGAND-RECEPTOR INTERACTIONS%REACTOME DATABASE ID RELEASE 66%10145666 Ligand-receptor interactions Gas1 Hhip Dhh Ihh Cdon Shh Ptch1 PLATELET HOMEOSTASIS%REACTOME DATABASE ID RELEASE 66%10145040 Platelet homeostasis Atp2b4 Atp2b2 Sri Atp2b1 Gnaq Gna11 Gna14 Gna15 Nos3 Pla2g4a Atp2a2 P2rx7 Atp2a3 Pde1b Pde3b P2rx1 Ptgir LOC497963 Slc8a3 Apob Slc8a2 Gng10 Slc8a1 Pde9a Pde5a Pde3a Pafah2 Prkg2 Pde2a Cyct Mrvi1 Pde10a Pde11a Nos1 Fgr Gnb3 Gnb5 Gnb2 Gnb1 Gng13 Gng12 Gng11 P2rx2 Lrp8 P2rx3 P2rx5 Itpr1 P2rx6 P2rx4 Itpr3 LOC100912034 Gnb4 Trpc3 Trpc7 Gng4 Gngt2 Mapk14 Gng5 Trpc6 Gngt1 Gng8 Gng3 CLASSICAL ANTIBODY-MEDIATED COMPLEMENT ACTIVATION%REACTOME%R-RNO-173623.1 Classical antibody-mediated complement activation C1s C1r C1qb C1qa ZINC TRANSPORTERS%REACTOME DATABASE ID RELEASE 66%10145654 Zinc transporters Slc30a5 Slc39a2 Slc30a6 Slc39a3 Slc30a8 Slc39a4 Slc39a14 Slc39a6 Slc39a7 Slc39a8 Slc30a1 TRANSCRIPTIONAL REGULATION BY SMALL RNAS%REACTOME DATABASE ID RELEASE 66%10146071 Transcriptional regulation by small RNAs Nup93 Nup43 Nup98 Nup133 Nup107 Aaas RGD1306195 RGD1565904 Nup210 Npap60 Polr2g Polr2h Nup35 Polr2e Polr2f Polr2j Nup37 Polr2k Nupl2 Polr2d Tnrc6a Polr2i Polr2b Polr2c Nupl1 Polr2a Hist1h2bo Hist1h2bcl1 Hist2h3c2 LOC100912534 Hist1h2bk H3f3b Nup205 Ranbp2 LOC100910200 H2afx Hist1h4b LOC684841 Hist1h2bh LOC100912290 Nup155 Hist1h2ail1 Hist1h4m LOC102549173 LOC103690002 LOC100910152 LOC100912338 Hist1h3c H2afb3 Hist1h3f Nup88 Hist2h4 LOC684819 Hist1h3a H2afj LOC100911822 Hist2h2aa3 Hist1h2bq Hist2h2aa2 Nup85 LOC100364835 LOC684762 Nup153 Ago2 Tpr Rae1 Nup54 Pom121 Hist1h2bg LOC680097 Nup62 LOC684797 LOC100912418 Hist1h2ba Hist3h2bb INTERFERON SIGNALING%REACTOME%R-RNO-913531.1 Interferon Signaling LOC100912571 Camk2g Irf3 Stat1 Jak1 Pde12 Stat2 Pias1 Ptpn1 Oasl Rnasel Abce1 Camk2d Camk2a Socs3 Uba7 Ube2l6 Eif4g1 Sumo1 Eif4g2 Eif4g3 Ptpn2 Flnb Isg15 Trim25 Eif2ak2 Ppm1b Ube2n Usp18 Eif4e3 Mx1 Eif4a2 Mx2 Eif4a1 Tyk2 LOC680559 Irf9 Prkcd Ifngr2 Eif4e2 Ifngr1 Arih1 Ddx58 LOC100911431 Ifng Socs1 Eif4a3 Ifnar2 Ifna5 Ifna4 Ptpn11 LOC100912356 LOC100911527 Ptpn6 Ifna11 LOC100912859 Ifnar1 Plcg1 RGD1560539 Ifna2 Ifnb1 LOC103690314 LOC100912314 Ifna16l1 RGD1565911 RGD1561827 IRS ACTIVATION%REACTOME DATABASE ID RELEASE 66%10144874 IRS activation Grb10 Insr Ins1 Irs2 Ins2 Irs1 BUTYROPHILIN (BTN) FAMILY INTERACTIONS%REACTOME%R-RNO-8851680.1 Butyrophilin (BTN) family interactions Btn1a1 LOC684480 Cd209a Btnl2 Xdh Cd209b Cd209e Btn2a2 Ppl Clec4m NUCLEOTIDE SALVAGE%REACTOME%R-RNO-8956321.1 Nucleotide salvage Cda Adal Pnp Uck1 Tymp Ampd3 Dck LOC100909857 Aprt Gmpr2 Uckl1 Tk2 Ampd1 Gmpr Hdhd1 Uck2 Upp1 Upp2 Tk1 Dguok Hprt1 Ada Ampd2 COENZYME A BIOSYNTHESIS%REACTOME%R-RNO-196783.1 Coenzyme A biosynthesis Pank4 Coasy Pank3 Pank2 Ppcs Pank1 LOC100362038 Ppcdc TRANSLESION SYNTHESIS BY POLK%REACTOME DATABASE ID RELEASE 66%10146111 Translesion synthesis by POLK Rfc1 Rfc2 Rev1 Rpa1 Rpa3 Rpa2 Mad2l2 Rfc5 Rev3l Rfc4 Rfc3 Pcna KERATINIZATION%REACTOME%R-RNO-6805567.1 Keratinization LOC100912586 LOC100363287 Krtap15-1 Tgm1 Krt10 LOC100910942 Krt13 LOC690386 Dsg4 Krt19 Klk8 Krt18 Dsg3 Krt15 Dsg2 Dsc3 Krt14 Ivl Krt17 Krt16 Spink5 RGD1561281 Dsc2 Krt33b Spink6 Krt33a LOC684499 LOC100910851 LOC100363184 LOC680396 Rptn LOC100911681 Krtap3-3 Krtap3-1 Lipk Lipm Krtap4-5 LOC100360690 Krt9 LOC689230 Krt7 Stfa2l1 Krtap4-7 Stfa2l3 Krt2 Stfa2l2 Krt8 LOC100910814 Krt4 Krtap4-13 LOC680160 Krtap11-1 LOC100363136 LOC100909618 LOC687631 Krtap12-2 LOC100365646 LOC689927 Krt75 Krtap8-1 Krt71 Krtap24-1 Krt77 Krt73 Krt72 Krtap1-1 Krt40 Krt76 Krtap1-3 Krtap13-2 Krtap27-1 Krtap1-5 Krtap14l Krt28 LOC100361664 Krt24 Krt23 Krt31 Krt25 Krt26 Krt27 LOC690460 Krt35 Krt34 Krt32 LOC690478 Krtap3-3l1 Krt39 Krt36 Jup Kb23 Krtap9-1 Krt81 Krt80 Krtap26-1 Krt82 Krt84 Krt83 Krt86 Dsp Krt85 Dsg1 RGD1565682 Pkp1 Pkp4 Pkp3 Sprr3 Klk12 Klk13 Klk14 Stfa3l1 Casp14 Stfa3 Evpl Csta LOC100911797 Ppl Perp Cela2a LOC100362978 MRNA 3'-END PROCESSING%REACTOME DATABASE ID RELEASE 66%10144830 mRNA 3'-end processing Thoc5 Rnps1 Thoc7 Thoc3 Thoc2 Thoc1 Magohb Wdr33 Rbm8a Pcf11 Fip1l1 Thoc6 Nudt21 Ddx39a Cstf2 Ddx39b Chtop U2af1l4 Cpsf7 Cpsf2 Cpsf3 Cpsf4 Cstf1 Cpsf1 Sarnp Slu7 Srsf3 Upf3b U2af2 Papola Srsf6 Srsf7 Srsf4 Srsf5 Srsf2 LOC679894 Srsf9 Dhx38 Clp1 Magoh Ncbp2 Srsf1 Poldip3 Ncbp1 Cstf2t Eif4a3 Fyttd1 Sympk LOC100910660 Srrm1 Cdc40 LOC361990 MITOCHONDRIAL BIOGENESIS%REACTOME DATABASE ID RELEASE 66%10145879 Mitochondrial biogenesis LOC100911417 Atp5f1 LOC500350 Sirt4 Sirt3 Atp5g3 Gabpb1 Acss2 Idh2 Atp5g2 Atp5l Atp5o Atp5h Mt-atp6 Atp5i Atp5j Atp5j2 Sod2 Atp5s Atp5e Atp5d Mt-atp8 Atp5b RIP-MEDIATED NFKB ACTIVATION VIA ZBP1%REACTOME%R-RNO-1810476.1 RIP-mediated NFkB activation via ZBP1 Nfkb2 Nfkb1 Ager S100b Dhx9 Nfkbib Chuk Nkiras1 App Nfkbia Nkiras2 Rela Ikbkb Myd88 TWIK-RELEATED ACID-SENSITIVE K+ CHANNEL (TASK)%REACTOME DATABASE ID RELEASE 66%10145845 TWIK-releated acid-sensitive K+ channel (TASK) Kcnk3 Kcnk9 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX%REACTOME DATABASE ID RELEASE 66%10144838 Formation of the ternary complex, and subsequently, the 43S complex Eif3l Eif2s3 Eif3m Eif3j Eif3k Rps20 Rps27l Eif3e Eif3f Eif3b Eif3a Eif3d Eif3c Rps16 LOC100360573 Eif2s1 Rps18 Eif2s2 LOC100360679 Rps15 Rps4x Rps3a LOC100359951 LOC100359593 LOC100359503 LOC100362640 Rps3 Rps15a Rps2 Rps13 Rps12 LOC100911372 LOC100361854 LOC684988 LOC103689992 Rps5 Rps7 Rps6 Eif3g Eif3h LOC100362830 Eif1ax LOC100363012 LOC100911110 LOC100362149 GLYCOGEN SYNTHESIS%REACTOME%R-RNO-3322077.1 Glycogen synthesis Epm2a Gys1 Gyg1 Pgm2l1 Gys2 Ugp2 Pgm2 Nhlrc1 Ppp1r3c Pgm1 IRAK1 RECRUITS IKK COMPLEX%REACTOME DATABASE ID RELEASE 66%10145768 IRAK1 recruits IKK complex LOC100362142 Ube2n LOC100912618 Peli3 Ube2v1 Chuk Ikbkb Peli2 Traf6 Peli1 G2 M DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 66%10144758 G2 M DNA damage checkpoint Rhno1 Rfc2 Bard1 Wrn Topbp1 Rbbp8 Rmi1 Rmi2 Bre Rad50 Brcc3 Pias4 Uimc1 Atm Hist1h2bo Hist1h2bcl1 Atrip Hist1h2bk Sumo1 Rpa3 Cdc25c Brca1 Rad1 Blm Atr Mdc1 Ube2v2 Rad17 Ube2n Rfc5 Rfc4 Rad9a Nbn Rfc3 Rad9b Mre11a Whsc1 LOC100910200 H2afx Hist1h4b Rnf8 Hist1h2bh LOC100912290 Hus1 Babam1 LOC686349 Tp53bp1 Hist1h4m LOC100912338 Herc2 Rpa1 Hist2h4 Ywhah Ywhag Rpa2 Sfn Ywhaz Hist1h2bq Ywhab Ywhaq Ywhae LOC100364835 Fam175a LOC100910954 Cdk1 Chek2 Wee1 Slc25a16 Hist1h2bg LOC680097 LOC684797 LOC100912418 Hist1h2ba Hist3h2bb SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%R-RNO-427359.1 SIRT1 negatively regulates rRNA expression LOC100910200 H2afx Hist1h4b LOC684841 Hist1h2bh LOC100912290 Hist1h2ail1 Hist1h4m LOC102549173 LOC103690002 LOC100910152 LOC100912338 Hist1h3c H2afb3 Hist1h3f Hist2h4 LOC684819 Hist1h3a H2afj Rrp8 Hist2h2aa3 Hist1h2bq Suv39h1 Hist2h2aa2 LOC100364835 LOC684762 Hist1h2bo Hist1h2bcl1 Hist2h3c2 Hist1h2bk H3f3b Hist1h2bg LOC680097 LOC684797 LOC100912418 Hist1h2ba Suv39h1l1 Hist3h2bb CONDENSATION OF PROMETAPHASE CHROMOSOMES%REACTOME DATABASE ID RELEASE 66%10145973 Condensation of Prometaphase Chromosomes Csnk2a2 Csnk2b Csnk2a1 Smc4 Ncapg Smc2 NEGATIVE REGULATION OF FGFR3 SIGNALING%REACTOME%R-RNO-5654732.1 Negative regulation of FGFR3 signaling Mknk1 Src Fgf16 Fgf17 Fgf9 Fgf2 Fgf8 Spry2 Cbl Fgfr3 Mapk1 Fgf23 Fgf4 Ptpn11 Fgf1 Ppp2cb Ppp2ca Ppp2r1a Fgf5 Frs2 Fgf20 Grb2 NEDDYLATION%REACTOME DATABASE ID RELEASE 66%10146142 Neddylation Ddb2 Vhl Asb18 Asb11 Ddb1 Asb12 Rbx1 Asb13 Asb14 Socs5 Asb10 Socs3 Keap1 Wdtc1 Asb15 Commd8 Asb17 Socs6 Asb16 Cops8 Cops2 Cul4b Cand1 Cul4a Birc5 Rfwd2 Nedd8 Ube2d1 Ercc8 LOC100911374 Dcaf11 Ube2d3 Cops4 Dcaf13 Cops6 Ankrd9 Dcaf10 Cops3 Fbxl22 Lrrc41 Skp2 Fbxw10 Fbxw12 Obsl1 Cul1 Commd9 Neurl2 Dcaf8 G6pc Klhl5 Dcaf4 Psmb7 Psmb1 LOC100910472 Klhl2 Fbxo2 Fbxo9 Fbxo7 Fbxo6 Psma5 Fbxo4 Cul9 Dcun1d2 Cops7b Ube2f Cops7a Psma2 Psmd2 Dcaf7 Commd3 Klhl9 Dcaf5 Psmc2 Dcaf6 Dda1 Psmd1 Lrr1 Psmd7 Psmd3 Psmd6 Psmc6 Psmb10 Psmb8 Psmb9 Ccdc22 Psmb4 Fbxl19 Psmb11 Psmb5 Psmf1 Fbxl12 Psmb6 Fbxl13 Psmd4 Fbxl16 Psmb2 Cish Fbxl15 Psmd5 Psmd8 Psmd9 Psmb3 Psma8 Psmd11 Ccnf Psmd12 Psmd13 Psmd14 Dtl Commd7 Commd2 Commd1 Tceb2 Tceb1 Cul2 Dcun1d5 Commd4 Hif1a Dcun1d4 Commd5 Dcun1d3 Commd6 Psmc3 Uchl3 Fem1b Fem1a Senp8 RGD1561252 Epas1 Hif3a Nae1 Fbxl4 Fbxl5 Fbxl8 Rbbp5 Kctd7 Rnf7 Fem1c Skp1 Kbtbd8 Kbtbd7 Kbtbd6 Kctd6 Fbxw11 Commd10 Btrc Gan Fbxl18 Fbxl7 Asb5 Asb6 Asb7 Klhl41 Asb1 Asb3 Asb8 Klhl42 Fbxo41 Ube2m Fbxo44 Fbxo40 Wsb2 Wsb1 Spsb3 Spsb2 Spsb1 Spsb4 Btbd1 Btbd6 Fbxo22 Wdr5 Klhl13 Rbbp7 Fbxo30 Fbxo31 Klhl11 Fbxo32 Fbxo21 Klhl20 Zbtb16 Klhl25 Klhl21 Klhl22 Fbxo10 Fbxo15 Tulp4 Fbxo11 Fbxw2 Psmc5 Uba3 Psma1 Fbxw9 Psma4 Nub1 Psmc1 Psma3 Fbxw5 Psmc4 Fbxw4 Psma6 Fbxw8 Psme1 Fbxw7 Psme2 LOC100909844 ORGANELLE BIOGENESIS AND MAINTENANCE%REACTOME DATABASE ID RELEASE 66%10145880 Organelle biogenesis and maintenance Atp5f1 Kif3c Kif3b Kifap3 Idh2 Arf4 Dync1i2 Nphp1 Cep57 Mt-atp6 Cep97 Rab8a B9d1 Cep162 LOC691918 Gbf1 Haus3 Ninl Akap9 Nphp4 Ccp110 Tmem216 Rpgrip1l Pafah1b1 Smo Wdr35 Kif3a Ift88 Dynll2 Cngb1 Inpp5e Tubb5 Ywhag Ppp2r1a Exoc3 Exoc2 Exoc1 Exoc6 Ywhae Exoc5 Exoc8 Exoc7 Nek2l1 Prkaca Nek2 Hdac6 Dync1h1 Ttc8 Bbs9 LOC103692716 Bbs1 Bbs2 Mchr1 Arl6 Rab3ip Lztfl1 Atp5j2 Trip11 Mt-atp8 Dctn1 Mks1 C2cd3 LOC500350 Cntrl Ift81 Dctn2 Sirt4 Cep76 Sirt3 Atp5g3 Sept2 Pcm1 Gabpb1 Acss2 Cep78 LOC100912537 Ttbk2 Mark4 B9d2 LOC100911033 Cep164 Dctn3 Cep41 Ofd1 Sclt1 Atp5g2 Sstr3 Tctn1 Sdccag8 Bbs7 Bbs5 Bbs4 Cep83 Prkar2b Cenpj Cep89 Plk4 Ift122 Sod2 Wdr19 Ttc21b Ahi1 LOC100911417 LOC100912076 Tubg2 Haus2 Ift46 Haus1 Ift43 Haus5 Alms1 Wdr60 Clasp1 Kif17 Haus4 Odf2 Tnpo1 Pde6d Tubb4a Cdk1 Iqcb1 Dynlrb2 Rab11a Ift74 Tmem67 Ttc26 Ssna1 Dynlrb1 Tubg1 Tcte3 Mapre1 Cep63 Atp5l Dync2li1 Csnk1d Atat1 Atp5o Pkd2 Cep131 Ift52 Atp5h Pkd1 Tuba4a Cep250 Hspb11 Atp5i Cnga4 Cep135 Ift57 Atp5j Cnga2 Csnk1e Traf3ip1 Cdk5rap2 Ckap5 Ift27 Kif24 Arl13b Pcnt Ift22 Cep72 Ift20 Sfi1 Atp5s Cluap1 Cep70 Atp5e Tctex1d1 Actr1a Atp5d Tctex1d2 LOC100911746 Ift140 Ttc30b Nedd1 Atp5b Ift80 Fbf1 P53-INDEPENDENT DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 66%10144753 p53-Independent DNA Damage Response Psmc6 Psmb10 G6pc Psmb8 Psmb9 Psmb4 Psmb11 Psmb5 Psmf1 Psmb6 Psmd4 Psmb2 Psmd5 Psmd8 Psmb7 Psmd9 Psmb1 Psmb3 Psma8 Psmd11 Psmd12 Psmd13 Psmd14 Psma5 Chek2 Psma2 Psmc5 Psmc3 Psma1 Psmd2 Psma4 Psmc1 Cdc25a Psma3 Psmc4 Psmc2 Psma6 Psme1 Psmd1 Psme2 Psmd7 Psmd3 Psmd6 TFAP2 (AP-2) FAMILY REGULATES TRANSCRIPTION OF CELL CYCLE FACTORS%REACTOME%R-RNO-8866911.1 TFAP2 (AP-2) family regulates transcription of cell cycle factors Tfap2c Bmyc REGULATION OF IFNG SIGNALING%REACTOME DATABASE ID RELEASE 66%10145739 Regulation of IFNG signaling Socs3 Ptpn2 Socs1 Stat1 Sumo1 Jak1 Ifngr2 Ifngr1 Pias1 Ifng FGFR1C LIGAND BINDING AND ACTIVATION%REACTOME%R-RNO-190373.1 FGFR1c ligand binding and activation Fgf23 Fgf4 Fgf1 Fgf17 Fgf6 Fgf5 Fgf9 Fgf2 Fgf8 Fgfr1 Fgf20 REGULATION OF RAS BY GAPS%REACTOME%R-RNO-5658442.1 Regulation of RAS by GAPs Psmc6 Psmb10 Psmb8 Psmb9 Psmb4 Psmb11 Psmb5 Psmf1 Psmb6 Psmd4 Psmb2 Psmd5 Psmd8 Psmd9 Psmb3 Psma8 Psmd11 Psmd12 Psmd13 Psmd14 Psmc3 Kras G6pc Psmb7 Psmb1 Rasal3 Psma5 Rasal1 Rasal2 Psma2 Psmc5 Rasa4 Psmd2 Psma1 Spred1 Psma4 Psmc1 Spred2 Psma3 Psmc4 Rasa2 Psmc2 Psma6 Rasa3 Psme1 Hras Psmd1 Psme2 Nras Psmd7 Nf1 Rasa1 Syngap1 Psmd3 Psmd6 RETROGRADE TRANSPORT AT THE TRANS-GOLGI-NETWORK%REACTOME%R-RNO-6811440.1 Retrograde transport at the Trans-Golgi-Network Vps53 Vps52 LOC100909548 Arfip2 Vps54 Rab6b Rab9a Napg Igf2r Ric1 Napb Napa Tgoln2 Rgp1 Nsf Stx16 Rab43 Cog4 Cog6 Arl1 Gcc1 Cog8 Golga1 Cog3 Golga4 Rhobtb3 Cog1 Cog2 Usp6nl Arfrp1 Rab6a Cog7 Scoc Stx6 M6pr Vamp4 Plin3 Vamp3 Rab9b Rabepk TRANSLOCATION OF SLC2A4 (GLUT4) TO THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 66%10145854 Translocation of SLC2A4 (GLUT4) to the plasma membrane Ywhah Ywhag Sfn Ywhaz Tbc1d1 Rala Ywhab Ywhaq Ywhae ACTIVATION OF NMDA RECEPTORS AND POSTSYNAPTIC EVENTS%REACTOME%R-RNO-442755.1 Activation of NMDA receptors and postsynaptic events Grin2d Rras Camk2g Grin2b Grin1 Nefl Rasgrf1 Gria3 Raf1 Dlg1 Gria4 Dlg2 Dlg3 Camk2d Actn2 Camk2a Rps6ka2 Rps6ka1 Lrrc7 Rps6ka3 Adcy3 Adcy8 Camkk1 Pdpk1 Mapk1 Creb1 Rps6ka6 Hras Camk4 Dlg4 INTERACTION WITH CUMULUS CELLS%REACTOME DATABASE ID RELEASE 66%10145974 Interaction With Cumulus Cells Spam1 Hyal5 INTERLEUKIN-9 SIGNALING%REACTOME%R-RNO-8985947.1 Interleukin-9 signaling Stat5a Jak3 Il2rg Stat1 Jak1 Stat3 Il9r Il9 SIGNALING BY NOTCH%REACTOME DATABASE ID RELEASE 66%10145914 Signaling by NOTCH Notch1 Dtx4 Dtx2 Tmed2 Aph1b Psenen Aph1a Dll4 Maml1 Notch4 Rbpj LOC100911293 Jag1 Egfr Psen2 Kat2a Notch3 Psen1 Ncstn Akt1 Rbpjl2 Prkci Ywhaz Elf3 Dtx1 Furin Ybx1 Snw1 Notch2 Mdk Crebbp SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE%REACTOME DATABASE ID RELEASE 66%10144727 Switching of origins to a post-replicative state Psmc6 Psmb10 Psmb8 Psmb9 Psmb4 Psmb11 Psmb5 Psmf1 Psmb6 Psmd4 Psmb2 Rbx1 Cul1 Psmd5 Psmd8 Psmd9 Psmb3 Psma8 Psmd11 Psmd12 Ccna2 Anapc11 Ccne2 Ccna1 Anapc15 Psmd13 Psmd14 Ccne1 Anapc10 Fzr1 Mcm2 Mcm4 Mcm3 Cdk2 Mcm5 Mcm6 Psmc3 Mcm8 Mcm7 Orc4 Orc5 Orc6 Orc1 Orc2 Orc3 Cdc6 G6pc Ube2d1 Psmb7 Psmb1 Skp1 Anapc7 Cdc26 Cdc27 Cdc23 Psma5 Ube2c Skp2 Anapc16 Cdt1 Cdc16 Anapc4 Psma2 Anapc2 Anapc1 Psmc5 Psmd2 Psma1 Psma4 Psmc1 Psma3 Psmc4 Psmc2 Psma6 Psme1 Psmd1 Psme2 Psmd7 Psmd3 Psmd6 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA-HYDROXYCHOLESTEROL%REACTOME DATABASE ID RELEASE 66%10145313 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol Nr1h4 Amacr Akr1d1 Ptgis Rxra Acot8 Hsd17b4 Slc27a5 Abcb11 Cyp7b1 Hsd3b7 Akr1c2 Ncoa2 Acox2 Akr1c3 Akr1c12l1 Cyp7a1 Slc27a2 Baat Cyp8b1 Akr1c19 Akr1c13 Akr1c14 RGD1564865 Akr1c12 Ncoa1 Akr1c1 SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 66%10145498 Semaphorin interactions Crmp1 Rras Plxna2 Rock1 Plxna1 LOC102552659 Sema7a Erbb2 LOC103692570 Hsp90ab1 Sema6d Nrp1 Cdk5r1 Rac1 Farp2 Cdk5 Sema5a Arhgap35 Trem2 Sema4d Plxnb1 Rock2 Tyrobp Arhgef11 Sema3a Sema3e Pip5k1c Ptprc Fyn Tln1 Cd72 LOC103692716 Limk1 Dpysl2 Dpysl5 Dpysl4 LOC100910964 Rhoa Fes Pak2 Pak3 Pak1 Rnd1 Plxnd1 Rhob Rhoc Dpysl3 CREATINE METABOLISM%REACTOME DATABASE ID RELEASE 66%10144813 Creatine metabolism Slc6a11 Slc6a12 Ckb Slc6a7 Ckmt1b Gamt PHOSPHORYLATION OF PROTEINS INVOLVED IN G1 S TRANSITION BY ACTIVE CYCLIN E:CDK2 COMPLEXES%REACTOME DATABASE ID RELEASE 66%10145275 Phosphorylation of proteins involved in G1 S transition by active Cyclin E:Cdk2 complexes Cdk2 Rb1 Ccne2 Ccne1 INTRINSIC PATHWAY OF FIBRIN CLOT FORMATION%REACTOME DATABASE ID RELEASE 66%10145080 Intrinsic Pathway of Fibrin Clot Formation A2m Serpine2 Serpind1 Serping1 Vwf Klkb1 Kng1l1 Gp1ba Serpinc1 Gp9 Gp5 Gp1bb LOC100911551 Kng1 Prcp F2 F8 F12 F11 F9 Serpina5 Kng2 C1qbp RUNX1 INTERACTS WITH CO-FACTORS WHOSE PRECISE EFFECT ON RUNX1 TARGETS IS NOT KNOWN%REACTOME%R-RNO-8939243.1 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Actl6b Smarce1 Pbrm1 Auts2 Pcgf5 Arid1b Arid1a Smarcd1 Csnk2a2 Smarcd2 Smarcd3 Hipk2 Csnk2a1 Phc1 Actl6a Phc2 Scmh1 Csnk2b Cbx4 Cbx2 Cbx8 Cbx6 Bmi1 Rnf2 Yaf2 Ring1 Smarca4 Smarca2 Phc3 Cbfb Arid2 Smarcc1 Smarcc2 Smarcb1 Runx1 SUMO IS TRANSFERRED FROM E1 TO E2 (UBE2I, UBC9)%REACTOME DATABASE ID RELEASE 66%10145988 SUMO is transferred from E1 to E2 (UBE2I, UBC9) Rwdd3 Sumo1 Sae1 Ube2i Uba2 VITAMIN D (CALCIFEROL) METABOLISM%REACTOME%R-RNO-196791.1 Vitamin D (calciferol) metabolism Cubn Cyp27b1 Cyp2r1 Cyp24a1 Vdr Lgmn Gc ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM%REACTOME%R-RNO-2046104.1 alpha-linolenic (omega3) and linoleic (omega6) acid metabolism Acsl1 Acaa1a Acot8 Fads1 Acaa1b Acox1 Elovl1 Elovl5 Hsd17b4 Elovl2 Elovl3 Abcd1 KERATAN SULFATE BIOSYNTHESIS%REACTOME%R-RNO-2022854.1 Keratan sulfate biosynthesis Kera Lum Prelp Chst5 LOC100911750 Chst2 Chst1 B3gnt4 B3gnt7 B3gnt1 B3gnt2 B3gnt3 Fmod Acan Omd LOC100910891 B4galt1 Ogn B4galt3 Slc35d2 B4galt2 B4galt6 St3gal2 St3gal3 B4galt4 B4galt5 St3gal1 St3gal4 St3gal6 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 66%10144723 Activation of the pre-replicative complex Gmnn Pole2 Pole4 Rpa1 Rpa2 Prim2 Pola2 Prim1 Mcm2 Mcm4 Mcm3 Cdk2 Mcm5 Rpa3 Mcm6 Mcm10 Pole Cdt1 Mcm8 Mcm7 Orc4 Orc5 Orc6 Orc1 Orc2 Orc3 Cdc7 Cdc6 Cdc45 HCN CHANNELS%REACTOME%R-RNO-1296061.1 HCN channels Hcn1 Hcn3 Hcn2 SUMOYLATION OF DNA REPLICATION PROTEINS%REACTOME%R-RNO-4615885.1 SUMOylation of DNA replication proteins Nup93 Nup43 Nup98 Nup133 Incenp Nup107 Top1 Pias3 Aaas Nup155 Nup210 Npap60 Nup35 Nup88 Nup37 Pias4 Nupl2 Nupl1 Nup85 Nup153 Cdca8 Sumo1 Tpr Rangap1 Sumo3 Rae1 Pcna Aurkb Nup54 Ube2i Pom121 Nup205 Ranbp2 Nup62 Birc5 HEDGEHOG 'ON' STATE%REACTOME%R-RNO-5632684.1 Hedgehog 'on' state Psmc6 Psmb10 Psmb8 Psmb9 Psmb4 Psmb11 Psmb5 Psmf1 Psmb6 Psmd4 Psmb2 Rbx1 Psmd5 Psmd8 Psmd9 Psmb3 Psma8 Psmd11 Psmd12 Psmd13 Psmd14 Rpgrip1l Smurf1 Smo Evc2 Kif3a Ift88 Psmc3 Mks1 Cdc73 Csnk1a1 RGD1564313 Dzip1 Sufu G6pc Dhh Cdon Shh Ptch1 Efcab7 Spop Iqce Spopl Ofd1 Ulk3 Psmb7 Boc Psmb1 Gli1 Gli3 Gli2 Ihh Evc RGD1559714 RGD1563667 Psma5 Psma2 Psmc5 Arrb1 Psma1 Psmd2 Ift52 Psma4 Kif7 Psmc1 Arrb2 Ift57 Psma3 Psmc4 Gas1 Psmc2 Hhip Psma6 Gas8 Psme1 LOC689173 Psmd1 Psme2 Adrbk1 Psmd7 Gpr161 Psmd3 Psmd6 FRS2-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 66%10145200 Frs2-mediated activation Ntrk1 Ngf Crkl Frs2 Rapgef1 LOC100911248 G BETA:GAMMA SIGNALLING THROUGH PLC BETA%REACTOME DATABASE ID RELEASE 66%10145577 G beta:gamma signalling through PLC beta Plcb1 Gnb3 Gnb5 Plcb3 Gnb2 Gnb1 Gng13 Gng12 Gng11 LOC100912034 Gnb4 Gng4 Gngt2 Gng5 Gngt1 Gng10 Gng8 Gng3 INHIBITION OF TSC COMPLEX FORMATION BY PKB%REACTOME%R-RNO-165181.1 Inhibition of TSC complex formation by PKB Tsc1 Tsc2 Akt2 NEGATIVE REGULATION OF FGFR1 SIGNALING%REACTOME%R-RNO-5654726.1 Negative regulation of FGFR1 signaling Src Fgf23 Fgf22 Fgf4 Fgf1 Fgf3 Ppp2cb Ppp2ca Fgf6 Fgf5 Ppp2r1a Fgf20 Mknk1 Fgf17 Fgf10 Fgf9 Fgf2 Fgf8 Spry2 Cbl Fgfr1 Mapk1 Ptpn11 Frs2 Grb2 PLASMA LIPOPROTEIN REMODELING%REACTOME%R-RNO-8963899.1 Plasma lipoprotein remodeling Gpihbp1 Lcat Lipg Pltp Angptl4 LOC100361444 Lmf1 Lmf2 Lpl Apoa1 Apob Apoc2 Apoe Apoa2 Abcg1 Pcsk6 Pcsk5 Furin AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE%REACTOME%R-RNO-352230.1 Amino acid transport across the plasma membrane Slc7a3 Slc16a10 Slc7a2 Slc7a1 Slc6a12 Slc1a5 Slc1a4 Slc7a8 Slc7a9 Slc7a5 Slc7a6 Slc7a7 Slc36a2 Slc7a10 Slc38a1 Slc6a15 Slc6a14 Slc6a19 Slc6a18 Slc36a4 Slc6a20 Slc6a6 Slc36a1 Slc38a3 Slc38a2 Slc38a5 Slc38a4 Slc7a11 Slc3a1 Slc25a29 Slc43a2 Slc43a1 APOPTOSIS INDUCED DNA FRAGMENTATION%REACTOME DATABASE ID RELEASE 66%10145440 Apoptosis induced DNA fragmentation Dffa Kpna1 Kpnb1 LOC100911856 Casp3 Hmgb2 RGD1559962 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL%REACTOME%R-RNO-209560.1 NF-kB is activated and signals survival Nfkb1 Sqstm1 Ngf Nfkbia Ngfr Ikbkb Rela Traf6 CELLULAR RESPONSE TO HEAT STRESS%REACTOME%R-RNO-3371556.1 Cellular response to heat stress Nup93 Camk2g Dnajb6 Nup43 Nup98 Nup133 l7Rn6 Nup107 Aaas Camk2d Vcp Camk2a Nup210 Npap60 Hspa14 Hspa13 Nup35 Nup37 Dnajc7 Nupl2 Hdac6 Nupl1 Ccar2 Hsph1 Atm Hspa12b Hspa12a Rpa3 LOC103692716 Ptges3 Ptges3l1 Atr Fkbp4 Nup205 Ranbp2 Crebbp Hsbp1 Dnajb1 Cryab Hsf1 Hspb8 Hspa1l Akt1s1 Hsp90ab1 Hspa2 Nup155 Rpa1 Nup88 Rpa2 Nup85 Ywhae Nup153 Mtor Bag1 Bag2 Bag4 Bag5 Rptor Bag3 Tpr Hspa9 Hspa5 Mlst8 Rae1 Hspa4 Mapkapk2 Mapk1 Nup54 Pom121 Nup62 TRANSPORT OF NUCLEOTIDE SUGARS%REACTOME%R-RNO-727802.1 Transport of nucleotide sugars Slc35c1 Slc35b2 Slc35d2 Slc35a2 Slc35d1 Slc35b3 Slc35a1 Slc35b4 SEPARATION OF SISTER CHROMATIDS%REACTOME DATABASE ID RELEASE 66%10145223 Separation of Sister Chromatids Cenpn Psmc6 Zwilch Cenpl Nup43 Cenpo Psmb10 Nup133 Dync1li2 Psmb8 Cenpt Psmb9 Cenpu Psmb4 Psmb11 Bub3 Psmb5 Bub1 Psmf1 Psmb6 Spdl1 Psmd4 Kntc1 Psmb2 Dync1i2 Psmd5 LOC100910252 Psmd8 Mad1l1 Stag1 Psmd9 Psmb3 Psma8 Cenpk Cenph Nup37 Cenpi Psmd11 Psmd12 Pds5b Pds5a Cenpf Cdca5 Psmd13 Rad21 Cenpe Psmd14 Smc1a Cenpm Stag2 Smc3 Ahctf1 Ndel1 Rcc2 Pafah1b1 Mis12 Dynll2 Psmc3 Ndc80 Cenpc Cenpa Dync1i1 Ranbp2 Birc5 Taok1 Ube2d1 Ppp2cb Ppp2ca Ppp2r1a Nup85 Anapc7 Cdc26 Cdc27 Cdc23 Pttg1 Ube2c Anapc16 Ppp2r1b Cdc16 Anapc4 Anapc2 Anapc1 Nup98 Nup107 Anapc11 Anapc15 Anapc10 Dync1h1 Cdca8 Dync1li1 Rangap1 Ppp1cc LOC100909468 Aurkb Sec13 Xpo1 LOC100911204 Spc24 Spc25 Hdac8 Itgb3bp Sgol2 Ppp2r5e Incenp G6pc Nsl1 B9d2 Cdc20 Kif2a Kif2c Kif2b Psmb7 Bub1b Psmb1 Kif18a Ppp2r5c Ppp2r5a Ppp2r5b Zwint Dsn1 Espl1 Mad2l1 Casc5 Clasp2 Ercc6l Psma5 Nuf2 Clasp1 LOC679582 Psma2 Mapre1 Psmc5 Psma1 Pmf1 Psmd2 Psma4 Psmc1 Psma3 Psmc4 Psma6 Ckap5 Psmc2 Psme1 Ska2 Psme2 Psmd1 Psmd7 Sgol1 Zw10 Psmd3 Ska1 Psmd6 GAMMA-CARBOXYLATION OF PROTEIN PRECURSORS%REACTOME%R-RNO-159740.1 Gamma-carboxylation of protein precursors Ggcx Pros1 Proz Bglap F2 F7 F9 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND%REACTOME DATABASE ID RELEASE 66%10145237 Removal of the Flap Intermediate from the C-strand Rpa1 Slc25a16 Rpa3 Fen1 Rpa2 Pold2 Pcna Pold1 Pold4 SMAC-MEDIATED APOPTOTIC RESPONSE%REACTOME DATABASE ID RELEASE 66%10145021 SMAC-mediated apoptotic response Diablo LOC100360940 Xiap PI-3K CASCADE:FGFR1%REACTOME%R-RNO-5654689.1 PI-3K cascade:FGFR1 Gab1 Fgf17 Pik3r1 Fgf10 Fgf9 Fgf2 Fgf8 Fgfr1 Fgf23 Fgf22 Fgf4 Ptpn11 Fgf1 Fgf3 Fgf6 Fgf5 Frs2 Fgf20 Grb2 METABOLISM OF COFACTORS%REACTOME DATABASE ID RELEASE 66%10145548 Metabolism of cofactors Nos3 Pts Idh1 Spr Prkg2 LOC103692716 Pdss2 Akt1 Gch1 Coq2 Gchfr EUKARYOTIC TRANSLATION ELONGATION%REACTOME%R-RNO-156842.1 Eukaryotic Translation Elongation Eef2 TELOMERE EXTENSION BY TELOMERASE%REACTOME DATABASE ID RELEASE 66%10145110 Telomere Extension By Telomerase Tert SIGNALLING TO ERKS%REACTOME DATABASE ID RELEASE 66%10145182 Signalling to ERKs Shc3 Kras Crk Rap1a Shc2 Mapkapk3 Mapkapk2 Ralgds Ntrk1 Kidins220 Ngf Hras Crkl Nras Sos1 Frs2 Mapk14 Rapgef1 Shc1 Mapk11 Grb2 LOC100911248 LAGGING STRAND SYNTHESIS%REACTOME%R-RNO-69186.1 Lagging Strand Synthesis Rfc1 Rfc2 Rpa3 LOC100911727 Pold2 Pcna Pold1 Pold4 Rpa1 Slc25a16 Rpa2 Fen1 Prim2 Pola2 Prim1 Rfc5 Rfc4 Rfc3 Lig1 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS%REACTOME DATABASE ID RELEASE 66%10145102 Post-translational modification: synthesis of GPI-anchored proteins Tectb Art3 Art4 LOC100910410 Mfi2 Ly6g6c Izumo1r Msln Vnn1 Rtn4rl2 Gpaa1 Rtn4rl1 Lypd5 Ceacam1 Prnd Lypd8 Lypd1 Lypd6b Ntng1 Lypd2 Ntng2 Prss41 Alpp Lypd3 Lypd4 Alpi Sprn Prss21 Alpl Plaur Ly6g6d Cpm Reck Folr2 Spaca4 Fcgr3a Gpihbp1 Tex101 Cd109 Opcml LOC100910849 Pigm Thy1 Pigk Otoa Cntn4 Pigl Cntn3 Pigg Cntn5 Ly6e Pgap1 Ly6d Pigh Psca Ly6h Alppl2 Pigc Pigb Piga Gpld1 Plet1 LOC100910143 Gp2 LOC100910177 Tecta Vnn3 Pigw Pigv Bst1 Pigy Pigx Pign Pigq Pigp Xpnpep2 Pigs Dpm3 Ceacam10 Dpm2 Pigu Dpm1 Pigt DIGESTION OF DIETARY LIPID%REACTOME%R-RNO-192456.1 Digestion of dietary lipid Pnliprp1 Pnliprp2 Pnlip Lipf Clps WNT5A-DEPENDENT INTERNALIZATION OF FZD4%REACTOME DATABASE ID RELEASE 66%10146042 WNT5A-dependent internalization of FZD4 Ap2a2 LOC100361515 Wnt5a Cltc Cltb Dvl2 Clta Arrb2 Fzd4 Prkca Prkcb Ap2s1 Ap2a1 Ap2m1 COMMON PATHWAY OF FIBRIN CLOT FORMATION%REACTOME%R-RNO-140875.1 Common Pathway of Fibrin Clot Formation LOC100909700 F13a1 Pf4 Serpine2 Serpind1 Fgb Fgg Cd177 Serpinc1 Pros1 Thbd Fga F13b Procr F2r F2 F8 Serpina5 ACYL CHAIN REMODELLING OF PS%REACTOME DATABASE ID RELEASE 66%10145868 Acyl chain remodelling of PS Lpcat4 Pla2r1 Pla2g5 Pla2g4e Pla2g4b Mboat1 Pla2g4d Pla2g16 Pla2g2a Pla2g2f Lpcat3 Pla2g2d Pla2g10 Osbpl10 Pla2g1b Pla2g4a Osbpl5 Osbpl8 Pla2g12a ASSEMBLY OF THE ORC COMPLEX AT THE ORIGIN OF REPLICATION%REACTOME DATABASE ID RELEASE 66%10144712 Assembly of the ORC complex at the origin of replication Orc4 Orc5 Orc6 Orc1 Orc2 Orc3 HSF1 ACTIVATION%REACTOME%R-RNO-3371511.1 HSF1 activation Ptges3l1 Hsf1 Hsp90ab1 Hdac6 LOC103692716 Ptges3 Ywhae Vcp NON-CODING RNA METABOLISM%REACTOME%R-RNO-194441.1 Non-coding RNA Metabolism Nup93 Nup43 Snrpf Nup98 Nup133 Nup107 Phax Aaas Nup155 Nup210 Snrpd1 Npap60 Snrpd2 Nup35 Snrpd3 Nup88 Snupn Nup37 Nupl2 Nupl1 Nup85 Nup153 Ncbp2 Ncbp1 Tpr Ddx20 Gemin7l1 Rae1 Tgs1 Gemin5 Gemin7 Gemin6 Nup54 Gemin8 Smn1 Pom121 Nup205 Ranbp2 Gemin2 Nup62 Snrpb REGULATION OF TP53 ACTIVITY THROUGH PHOSPHORYLATION%REACTOME DATABASE ID RELEASE 66%10144756 Regulation of TP53 Activity through Phosphorylation Rhno1 Rfc2 Bard1 Wrn Topbp1 Rbbp8 Mdm2 Rmi1 Rmi2 Dyrk2 Rad50 Cdk5 Csnk2a2 Tp53rk LOC364561 Pin1 Supt16h Csnk2a1 LOC685619 Ccna2 Ccna1 Aurka Plk3 Prkab1 Prkab2 Atm Atrip Cdk2 Rpa3 Atp5c1 Aurkb Taf7l Brca1 Rad1 Atr Blm Mapkapk5 Rad17 Rfc5 Rfc4 Rad9a Nbn Rfc3 Rad9b Tbp Mre11a Hus1 Cdk5r1 Taf11 Taf15 Taf2 Rpa1 Nuak1 Hipk2 Rpa2 Taf13 Taf9 Taf12 Taf7 Taf4b Taf3 Taf6 Noc2l Taf5 Tp53inp1 Csnk2b Prkag3 Tpx2 LOC100910954 Hipk1 Mdm4 Chek2 Prkaa1 Taf10 Prkaa2 Slc25a16 Ssrp1 Mapk14 Mapk11 Taf9b MITOCHONDRIAL TRANSLATION TERMINATION%REACTOME DATABASE ID RELEASE 66%10146065 Mitochondrial translation termination Mrps11 Mrps12 Mrps16 Mrps14 Mrps18b Mrps18c Mrps10 Mrps18a Mrps33 Mrps34 Mrps21 Mrps35 Mrps17 Mrps15 Mrps31 Mrps30 Mrps24 Mrps23 Mrps22 mrpl9 Mrps28 Mrps27 Mrps26 Mrps25 Mrpl4 Mrpl3 Mrpl2 Oxa1l Mtrf1l LOC367117 Mrrf Mrpl1 Mrpl13 Mrpl10 Mrpl18 Mrpl19 Mrps9 Mrps2 Mrps5 Mrps7 Mrpl36 Mrpl37 Mrpl20 Mrpl14 Mrpl16 Mrpl12 Mrpl15 Mrpl41 Mrpl35 Mrpl40 Mrpl33 Mrpl34 Mrpl38 Mrpl32 Mrpl27 Mrpl23 Mrpl28 Mrpl30 Mrpl21 Mrpl54 Mrpl46 Mrpl55 Mrpl44 Mrpl43 Mrpl47 Mrpl49 Mrpl53 Mrpl48 Mrpl52 Mrpl51 Mrpl50 mrpl11 mrpl24 Chchd1 Dap3 Eral1 Gadd45gip1 Ict1 Ptcd3 Gfm2 CONJUGATION OF CARBOXYLIC ACIDS%REACTOME DATABASE ID RELEASE 66%10145090 Conjugation of carboxylic acids Glyatl3 Acsm1 Glyat OPSINS%REACTOME%R-RNO-419771.1 Opsins Opn1sw Rgr Opn5 Opn3 Opn4 Opn1mw TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES%REACTOME DATABASE ID RELEASE 66%10144951 Transport of vitamins, nucleosides, and related molecules Slco1a1 Slc35b2 Slc35c1 Slc5a6 Slco4a1 Pdzd11 Slc27a6 Slco1a4 Slc35b3 Slco1a2 Slco4c1 Slco2b1 Lcn1 Slco1b2 Slc27a4 Slc33a1 Slc35a2 Slc16a2 Slc21a4 Slc35b4 Avp Slco1a6 Slc28a2 Slc35d1 Slc28a1 Slco3a1 Slc28a3 Slc29a3 Slc35a1 Slc29a2 Slc29a4 Lcn12 LOC100911721 Slc29a1 LOC691960 Slc35d2 Slco2a1 Apod Vegp2 Slco1c1 Lcn9 Slc27a1 EICOSANOID LIGAND-BINDING RECEPTORS%REACTOME%R-RNO-391903.1 Eicosanoid ligand-binding receptors Ptgir Gpr17 Tbxa2r Ptgdrl Ptger3 Ltb4r Cysltr2 Cysltr1 Ltb4r2 Ptgdr Ptgfr Ptger2 Ptger1 Ptgdr2 FRUCTOSE METABOLISM%REACTOME%R-RNO-5652084.1 Fructose metabolism Aldob Khk Glyctk Akr1b1 Sord Tkfc B-WICH COMPLEX POSITIVELY REGULATES RRNA EXPRESSION%REACTOME DATABASE ID RELEASE 66%10146051 B-WICH complex positively regulates rRNA expression Myo1c Kat2a RGD1565904 Polr1b Taf1d Polr2h Taf1c Cd3eap Polr2e Znrd1 Polr2f Polr1c Polr1a Polr2k Hist1h2bo Hist1h2bcl1 Hist2h3c2 LOC100912534 Hist1h2bk Actb H3f3b Sf3b1 Smarca5 Tbp LOC100910200 H2afx Hist1h4b LOC684841 Hist1h2bh LOC100912290 Hist1h2ail1 Hist1h4m LOC102549173 Mybbp1a LOC103690002 LOC100910152 LOC100912338 Hist1h3c H2afb3 Hist1h3f Ercc6 Hist2h4 LOC684819 Hist1h3a H2afj Hist2h2aa3 Hist1h2bq Hist2h2aa2 Ddx21 LOC100364835 Baz1b LOC684762 Twistnb Polr1e Hist1h2bg LOC680097 LOC684797 LOC100912418 Hist1h2ba Hist3h2bb Dek PCNA-DEPENDENT LONG PATCH BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 66%10144982 PCNA-Dependent Long Patch Base Excision Repair Rfc1 Rfc2 Rpa3 Pole2 Pole4 LOC100911727 Pole Polb Pold2 Pcna Pold1 Pold4 Rpa1 Rpa2 Fen1 Apex1 Rfc5 Rfc4 Rfc3 Lig1 TNFS BIND THEIR PHYSIOLOGICAL RECEPTORS%REACTOME DATABASE ID RELEASE 66%10146122 TNFs bind their physiological receptors Tnfsf13b Tnfrsf9 Tnfrsf8 Edaradd Tnfrsf4 Eda2r Tnfrsf1b Cd70 Tnfrsf17 Tnfrsf14 Tnfsf8 Tnfsf9 Tnfrsf25 Edar Tnfrsf11b Tnfsf4 Eda Tnfsf11 Lta Tnfsf13 Cd27 INTERLEUKIN-37 SIGNALING%REACTOME DATABASE ID RELEASE 66%10146292 Interleukin-37 signaling Tbk1 Stat3 RETROGRADE NEUROTROPHIN SIGNALLING%REACTOME%R-RNO-177504.1 Retrograde neurotrophin signalling Dnal4 Ap2a2 Ntrk1 Clta Ngf Sh3gl2 Ap2s1 Ap2a1 Ap2m1 Cltc PRPP BIOSYNTHESIS%REACTOME%R-RNO-73843.1 PRPP biosynthesis Prps1l1 Prps2 RHO GTPASES ACTIVATE KTN1%REACTOME%R-RNO-5625970.1 RHO GTPases activate KTN1 Rhoa Klc1 Ktn1 Klc4 Kif5b Rhog Kif5a Klc2 Rac1 Klc3 Cdc42 PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS%REACTOME%R-RNO-202427.1 Phosphorylation of CD3 and TCR zeta chains Cd247 Ptprc Csk Ptpn22 Ptprj Cd3g Cd3e RT1-Ba Cd3d RT1-Bb RT1-Da RT1-Db2 Cd4 RT1-Db1 LOC688090 ACTIVATION OF GABAB RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145188 Activation of GABAB receptors Kcnj4 Kcnj6 Gnai3 Gnal Gnat3 Adcy3 Adcy8 Adcy9 Adcy5 Gnai2 Adcy4 Adcy7 Adcy6 Gnb3 Kcnj16 Gnb2 Gnb1 Gng12 Kcnj2 Kcnj3 Kcnj15 Kcnj9 Kcnj5 Gng4 Gngt2 Gnai1 Gng5 Gabbr1 Gngt1 Kcnj12 Gng10 Gng8 Gabbr2 Gng3 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS%REACTOME%R-RNO-442742.1 CREB phosphorylation through the activation of Ras Grin2d Camk2g Rras Grin2b Grin1 Nefl Rasgrf1 Dlg1 Raf1 Dlg2 Dlg3 Camk2d Pdpk1 Actn2 Camk2a Mapk1 Rps6ka2 Rps6ka1 Lrrc7 Rps6ka3 Creb1 Rps6ka6 Hras Dlg4 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 66%10145158 Activation of the AP-1 family of transcription factors Jun Mapk9 Mapk8 Fos Mapk14 Atf2 Mapk11 Mapk10 Mapk1 SYNTHESIS OF DOLICHYL-PHOSPHATE-GLUCOSE%REACTOME DATABASE ID RELEASE 66%10145673 Synthesis of dolichyl-phosphate-glucose Nudt14 PTK6 REGULATES RTKS AND THEIR EFFECTORS AKT1 AND DOK1%REACTOME DATABASE ID RELEASE 66%10146206 PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 Arap1 Dok1 Cbl Akt1 Ptk6 COHESIN LOADING ONTO CHROMATIN%REACTOME%R-RNO-2470946.1 Cohesin Loading onto Chromatin Stag1 Pds5b Pds5a Rad21 Smc1a Mau2 Stag2 Smc3 SEMA3A PAK DEPENDENT AXON REPULSION%REACTOME DATABASE ID RELEASE 66%10145582 Sema3A PAK dependent Axon repulsion Plxna2 Plxna1 Fyn Hsp90ab1 LOC103692716 Nrp1 Rac1 Limk1 Pak2 Fes Pak3 Pak1 Sema3a ATTENUATION PHASE%REACTOME DATABASE ID RELEASE 66%10146014 Attenuation phase Ptges3l1 Hsbp1 Dnajb1 Hsf1 Fkbp4 Hspa1l Hsp90ab1 Hspa2 Crebbp LOC103692716 Ptges3 RNA POLYMERASE II TRANSCRIPTION%REACTOME DATABASE ID RELEASE 66%10144750 RNA Polymerase II Transcription Thoc5 Rfc2 Thoc7 Thoc3 Gtf2h1 Thoc2 Gtf2h2 Usp7 Thoc1 Mdm2 Nrbf2 Zfp28-ps1 Zfp445 Banp Zfhx3 Notch3 Rarg Esr2 Mnat1 Thoc6 Rbx1 RGD1565904 Nr2c2ap Cdk5 Ice2 Hnf4a RGD1308751 Leo1 Zc3h8 Polr2g Hnf4g Polr2h Zfp473 Polr2e Nr4a3 Polr2f Nr4a1 Polr2j Nr4a2 Polr2k LOC685619 Polr2d Zfp212 Polr2i Zfp418 Polr2b Pml Ddx39a Polr2c Zfp213 Ddx39b Polr2a Zfp867 Actl6a Ice1 Chtop Esrra Esrrb LOC100912534 Triap1 Elf1 Ell Sumo1 Elf2 Rpa3 Tp53bp2 Nr6a1 Nr2c2 Nr2c1 Atp5c1 Cited2 Iws1 Zkscan1 Tcea1 Zfp263 Pcna Zfp266 Taf7l Brca1 Zfp496 Ccnh Blm LOC102555919 Mapkapk5 Rara Pcgf2 Rarb Yap1 Zfp498 Tead2 Pidd1 Tead1 Nr2e1 Ube2i Hdac4 Ppm1d Zfp483 Nr2f6 Rbm14 Gtf2h3 Rfc5 Nr2f1 LOC100911677 Rfc4 Zfp287 Rfc3 LOC691135 Sox9 Nr2e3 Gtf2h5 Thra Zfp282 Gtf2h4 Thrb Zfp786 Smad3 Ing2 Aff4 Actl6b Ccnt2 Zfp770 Smad2 Smarce1 Zfp771 Zfp354c Nr1h3 Gtf2e1 Nr1h2 Pbrm1 Tceb3 Arid1b Zfp354a Arid1a Usp9x Sp1 Zfp791 Ube2d1 Gtf2e2 Skil Zfpm1 Rbl1 Nr5a1 Cdk4 Ncor2 Cdk9 Akt1 Rora Nr1i2 E2f4 Supt6h Smarcd1 LOC102554302 Hdac1 Tgif2 Smarcd2 Ercc3 Tgif1 LOC100911274 Smarcd3 Atp1b4 Brpf3 Nuak1 Rpa1 Trim33 Ccnd1 Foxp3 Rpa2 Ccnk Brpf1 Ube2d3 LOC100911822 LOC100363472 Brd1 Taf7 Nr1i3 Cpsf3l Wwtr1 Tfdp1 Taf3 Ercc2 Kat6a Taf6 Tfdp2 Taf5 Ing5 Taf8 Stub1 Zfp202 Tp53inp1 MGC114246 Zfp839 Zfp420 LOC100911519 Tbx5 Runx2 Rxrg Tp63 Nrbp1 Yaf2 Zfp426 LOC102553866 Fyttd1 Nelfe Nelfa Nelfb Gtf2b Testin Znf740 Cradd Bnip3l Slc25a16 Asun RGD1562299 Znf750 Ssrp1 L3mbtl1 L3mbtl2 Zfp775 Zfp777 Dek LOC361990 Ints4 Ints5 Ints6 Map2k6 Ints7 Ints9 Zfp746 Phax Zfp583 Ints1 Ints3 Ints2 Zfp180 Zfp189 Dyrk2 Epc1 Cul1 Zfp804b Zfp703 Tp53rk LOC100911224 Zfp707 Zfp710 Supt16h Zfp711 Krba1 Ssu72 Zfp566 Zfp169 Zfp167 Vwa9 Zfp383 Zfp37 Zfp113 Zfp110 Zfp382 Zfp112 Zfp46 Zfp398 Zfp111 Trim28 Zfp394 Zfp2 LOC100364523 Sarnp Zfp317 Zfp597 Zfp74 LOC501406 Zfp9 Zfp1 Zfp84 Nabp1 Nabp2 Rslcan18 Serpinb13 Slu7 Zfp90 Zim1 Zfp641 Zfp647 LOC102549842 LOC102555083 LOC102546354 Auts2 Pax5 LOC102553962 Mga Zfp668 Snapc3 Cdk5r1 Snapc4 Lsm10 Lsm11 Zfp667 Psmb7 Prelid1 Psmb1 Taf11 LOC679894 Ctsl Taf15 Zfp248 Esrrg Ctsm Taf13 Ctsj Taf12 RGD1564657 Mllt1 Ctsk Taf4b Ctsq Rpap2 Ctsr Nr0b1 Noc2l Nr0b2 Poldip3 Psma5 Max Parp1 Supt4h1 Pou4f2 Zfp286a Cdk7 Hipk1 E2f6 Zfp324 Psma2 Slbp Psmd2 Brd2 Zfp697 Zfp612 Cts8 Zfp692 Cts7 Zfp691 Psmc2 Snapc5 Snapc2 Ppp1r13b Psmd1 LOC100910137 Psmd7 RGD1564827 Ppp1r13l Zfp606 Ttc5 Zfp688 Psmd3 Rorb Psmd6 Rhno1 Bard1 Wrn Snrpf Topbp1 Rbbp8 Rmi1 Rmi2 Wdr33 Rad50 Lhb Gata2 LOC100911167 LOC364561 Pin1 Brd7 Sesn2 Tal1 Plk2 Ldb1 Txnrd1 Ccne2 Sesn1 Plk3 RragB Ccne1 Tp73 Prkab1 Sesn3 Gata1 Lmo2 Prkab2 Gsr Lmo1 Atrip Cts8l1 Cdk2 E2f7 E2f8 Btg2 Cnot6l Cnot11 Rad1 Atr Rad17 Tgfb1 Setd8 Tmem55b Rad9a Nbn Pip4k2b Cga Rad9b Pip4k2c Mre11a Rbbp5 Srsf3 Upf3b U2af2 Papola Hus1 Srsf6 Srsf7 Srsf4 Tfap2a Srsf5 Srsf2 Tnks1bp1 Cnot8 Rqcd1 Ppp2cb Cnot3 Ppp2ca Cnot1 Skp1 Srsf9 Ppp2r1a Cnot2 Dhx38 Clp1 Cnot7 Cnot4 Phc1 Magoh Phc2 Ncbp2 Mtor Prdx1 Srsf1 Ddit4 Rheb Prkag3 Rptor Lamtor4 Ncbp1 LOC502894 Tfap2b Tsc1 Tfap2c Lamtor5 Sin3a Ppp2r1b Txn1 Cstf2t Sin3b Mlst8 Eif4a3 Prkaa1 Sympk Tsc2 Tfap2d Rraga Tfap2e Prkaa2 Rragc Akt3 LOC100910660 Rragd Srrm1 Slc38a9 Mapk14 Cdc40 Mapk11 Snrpb Rxra Pparg Prmt5 Prmt6 Hist1h2bo Hist1h2bcl1 Scmh1 Cbx4 Hist2h3c2 Cbx2 Hist1h2bk H3f3b Cbx8 Smurf1 Cbx6 Bmi1 Hdac2 Rnf2 Mbd3 E2f5 Ring1 Smarca4 Hdac1l Chd3 Smarca2 Snw1 Chd4 Phc3 LOC100911617 Arid2 Zfp385a Smarcc1 Smarcc2 Smarcb1 Mta2 Gatad2a Cdk6 Meaf6 Gatad2b LOC100909949 Eed Cdc73 Atad2 Ccnd3 LOC100910200 H2afx Hist1h4b Wdr5 LOC684841 Kmt2a Smyd2 Hist1h2bh LOC100912290 Rbbp7 Hist1h2ail1 Hist1h4m LOC102549173 LOC103690002 Ehmt2 LOC100910152 Ehmt1 LOC100912338 Hist1h3c H2afb3 Hist1h3f Hist2h4 Cenpj LOC684819 Hist1h3a H2afj Hist2h2aa3 Hist1h2bq Hist2h2aa2 Ash2l LOC100364835 Dpy30 LOC684762 Cited4 Yeats4 Tcf7 Hist1h2bg Ezh2 Lef1 Tcf7l1 LOC680097 LOC684797 LOC100912418 Hist1h2ba Hist3h2bb Nr1h4 Maml1 Rbpj Kat2a Rbpjl2 Csnk2a2 Csnk2a1 LOC100909750 Paf1 Vdr Rtf1 Hipk2 Supt5h Rnmt Rngtt Skp2 Cdkn1a Cdkn1b Chm Gadd45a Bax Rnps1 Magohb Rbm8a Pcf11 Fip1l1 Rabggta Nudt21 Snrpd3 Ppara Ppard Aurka Cstf2 U2af1l4 Cpsf7 Cdc25c Cpsf2 Cpsf3 Cpsf4 Cstf1 Cpsf1 Aurkb Rabggtb Abl1 G6pc Men1 Ppp2r5c Gpi Pdpk1 Psmc6 Psmb10 Psmb8 Psmb9 Psmb4 Psmb11 Psmb5 Psmf1 Psmb6 Psmd4 Psmb2 Psmd5 Psmd8 Psmd9 Psmb3 Psma8 Psmd11 Psmd12 Ccna2 Ctr9 Ccna1 Psmd13 Rffl Ccng1 Psmd14 Phf20 Atm Rictor Wdr61 Tceb2 Tceb1 Psmc3 Src Ywhah Ywhag Sfn Ywhaz Ywhab Ywhaq Ywhae Med1 Lamtor3 Cited1 Nr5a2 Gtf2f1 Gtf2f2 Lamtor2 Lamtor1 Gtf2a1 Bmyc Prmt1 Esr1 Pou2f1 Cbfb Gata3 Crebbp Pgr Tbp Runx1 Akt2 Nr1d1 Notch1 Pcgf6 Rprd1a Kras Nr1d2 Pcgf5 Notch4 Cdk12 Eaf1 Eaf2 Taf2 Zfp14 Slmo1 Taf9 RGD1562871 Ell3 Zfp12 Casp2 Ell2 Cdk13 Zfp13 Rprd1b Zfp28 Zfp18 Csnk2b Usp2 Tpx2 Daxx LOC100910954 Cdk1 Mdm4 Chek2 Rnf34 Taf10 Mapkap1 Sgk1 Psmc5 Psma1 Psma4 Psmc1 Ptpn11 Psma3 Notch2 Psmc4 Psma6 Psme1 Psme2 Taf9b ROLE OF ABL IN ROBO-SLIT SIGNALING%REACTOME%R-RNO-428890.1 Role of ABL in ROBO-SLIT signaling LOC100909750 Abl2 Robo1 Abl1 Slit2 SIGNALING BY FGFR3%REACTOME DATABASE ID RELEASE 66%10145259 Signaling by FGFR3 Src Kras Pik3r1 Frs3 Fgf23 Fgf22 Fgf4 Fgf1 Ppp2cb Fgf3 Ppp2ca Fgf6 Ppp2r1a Fgf5 Fgf20 Mknk1 Gab1 Fgf16 Fgf17 Fgf10 Fgf9 Fgfr2 Fgf2 Fgf7 Cbl Spry2 Fgf8 Fgfr3 Fgfr1 Mapk1 Fgfr4 Ptpn11 Plcg1 Fgf19 Hras Nras Frs2 Sos1 Shc1 Galnt3 Grb2 COLLAGEN FORMATION%REACTOME%R-RNO-1474290.1 Collagen formation Mmp7 Col19a1 LOC100911730 Mmp9 Pcolce RGD1308751 Cd151 Lamc2 Itgb4 Itga6 Col22a1 Col16a1 Col5a2 Col5a1 Cts8l1 Col4a5 Col27a1 Col9a1 Col9a2 Col9a3 Lox Plec Col4a1 Col5a3 LOC100364523 Bmp1 Col4a2 Col4a3 Crtap Col7a1 Col23a1 Lamb3 Col6a5 Col6a6 Col20a1 P4ha1 P4ha2 P4ha3 Dst LOC100910835 Col13a1 Mmp13 LOC100910384 Adamts3 Serpinh1 Ctsb Col8a1 Ctsl Col8a2 Col3a1 Ctsm Ctsj RGD1564657 Col28a1 Col1a1 Ctsq Ctsr Col1a2 Ppib Col6a1 Col6a2 Col18a1 MGC114246 P4hb Adamts14 Tll2 Col11a2 Col11a1 Mmp20 Tll1 Testin LOC100911572 P3h3 Loxl4 Cts8 Colgalt2 Cts7 Col26a1 Col14a1 Plod2 Plod1 Loxl1 RGD1564827 LOC102555086 Colgalt1 Plod3 Col17a1 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION%REACTOME%R-RNO-3134963.1 DEx H-box helicases activate type I IFN and inflammatory cytokines production Nfkb2 Nfkb1 App Ager S100b Dhx9 Rela Myd88 Dhx36 SUMOYLATION OF SUMOYLATION PROTEINS%REACTOME DATABASE ID RELEASE 66%10146029 SUMOylation of SUMOylation proteins Nup93 Nup43 Nup98 Nup133 Nup107 Aaas Nup155 Nup210 Npap60 Nup35 Nup88 Nup37 Pias4 Nupl2 Nupl1 Nup85 Nup153 Sumo1 Tpr Rae1 Nup54 Pom121 Nup205 Ube2i Ranbp2 Nup62 Topors REGULATED NECROSIS%REACTOME%R-RNO-5218859.1 Regulated Necrosis Faslg Cflar Fadd Birc3 Birc2 Mlkl Ripk3 Traf2 Ripk1 Tradd Xiap Tnfsf10 Casp8 Fas SYNTHESIS OF 15-EICOSATETRAENOIC ACID DERIVATIVES%REACTOME DATABASE ID RELEASE 66%10145944 Synthesis of 15-eicosatetraenoic acid derivatives Alox15b Gpx4 Ptgs2 Alox15 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA%REACTOME%R-RNO-212718.1 EGFR interacts with phospholipase C-gamma Plcg1 Egfr PHOSPHORYLATION OF EMI1%REACTOME DATABASE ID RELEASE 66%10145225 Phosphorylation of Emi1 Cdk1 Cdc20 Fzr1 Fbxo5 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY%REACTOME%R-RNO-3301854.1 Nuclear Pore Complex (NPC) Disassembly Nup93 Nup43 Nup98 Nup133 Nup107 Aaas Nup155 Nup210 Npap60 Nup35 Nup88 Nup37 Nupl2 Nupl1 Nup85 Nup153 Tpr Cdk1 Rae1 Nup54 Pom121 Nek6 Nup205 Ranbp2 Nup62 Nek7 REPRESSION OF WNT TARGET GENES%REACTOME DATABASE ID RELEASE 66%10146038 Repression of WNT target genes Ctbp2 Tle3 Tcf7 Lef1 Tcf7l1 Tle4 Tle1 Tle2 APOPTOTIC EXECUTION PHASE%REACTOME DATABASE ID RELEASE 66%10145388 Apoptotic execution phase Prkcd Bmx Kpnb1 Rock1 Apc Dsg3 Dsg2 Birc2 Sptan1 Lmna Dffa Kpna1 LOC100911856 Casp3 Mapt Casp6 Hmgb2 RGD1559962 Stk26 Stk24 Add1 Acin1 Gas2 Ocln Tjp2 Bcap31 Dsp Cdh1 Casp8 Dsg1 Clspn Prkcq Dnm1l Plec Gsn Lmnb1 Pkp1 Vim Dbnl Fnta Ptk2 Satb1 RUNX3 REGULATES NOTCH SIGNALING%REACTOME%R-RNO-8941856.1 RUNX3 regulates NOTCH signaling Notch1 Maml1 Rbpj Crebbp Kat2a Snw1 Rbpjl2 VEGFR2 MEDIATED CELL PROLIFERATION%REACTOME DATABASE ID RELEASE 66%10146032 VEGFR2 mediated cell proliferation Prkcd Kras Src Kdr Pdpk1 Vegfa Prkca Plcg1 Prkcb Hras Nras Rasa1 Prkcz NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145596 Nucleotide-like (purinergic) receptors P2ry6 Lpar6 P2ry4 P2ry1 Gpr17 Lpar4 Adora3 Adora2a Adora2b LOC100911796 P2ry12 P2ry2 LOC100363178 Adora1 P2ry10 LOC100365814 P2ry13 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 27-HYDROXYCHOLESTEROL%REACTOME%R-RNO-193807.1 Synthesis of bile acids and bile salts via 27-hydroxycholesterol Nr1h4 Akr1d1 Ptgis Ncoa2 Akr1c2 Akr1c3 Akr1c12l1 Cyp7a1 Rxra Cyp8b1 Akr1c19 Akr1c13 Akr1c14 RGD1564865 Cyp7b1 Hsd3b7 Akr1c12 Ncoa1 Akr1c1 INTEGRIN SIGNALING%REACTOME DATABASE ID RELEASE 66%10145478 Integrin signaling Fn1 Src Csk Tln1 Crk Rasgrp1 Rasgrp2 Rap1a Vwf Apbb1ip Ptpn1 Bcar1 Fgb Fgg Pdpk1 Akt1 Rapgef4 Fga Itga2b Ptk2 Sos1 Shc1 Syk Grb2 G ALPHA (I) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 66%10144868 G alpha (i) signalling events Plcb1 Cnga1 Ppp1ca Pde4a Gucy2f Pde6b Plcb3 Rcvrn Gucy2d Pde4d Pde4c Pde6a Rgs9 Ppp1r1b RGD1560341 Cdk5 Stra6 Rdh10 Rdh16 LOC100365958 LOC100362350 Akr1c12l1 Plcb4 Guca1b Ppef1 Kng1l1 Metap2 Metap1 Gnat1 Akr1c19 Nmt1 Guca1a Cngb1 Rgs9bp Fnta Nmt2 Akr1c13 Akr1c14 Sag Grk4 Grk1 Akr1c12 Fntb Pde6g Ccr6 Gnai3 Pomc Pnlip Apoa1 Gnao1 Chrm4 Rpe65 Clps Gnat2 Dhrs9 Myo7a Gnaz Sdr9c7 Hsd17b6 Gpc6 Gpc4 Gpc2 Abca4 Prkca Gpc1 Opn1sw Oprl1 Tas2r144 Grm3 Ccl21 Casr Dhrs3 Rlbp1 Ccr5 Grm6 Gal Tas2r113 Ccr4 Grm2 Ccr3 Grm8 Gpr37 Ccl27 Tas2r114 Tas2r110 Gper1 Ccl20 Ccl25 Akr1b7 NMS Akr1b8 Tas2r124 Cxcl16 App Tas2r125 Pdyn Tas2r126 Tas2r121 Ccr10 Tas2r103 Gpr37l1 Tas2r104 Tas2r123 Ccl19 Ccr7 Tas2r116 Ccr8 Tas2r140 Tas2r120 Cxcr3 Cxcl10 Tas2r102 Ccr9 Opn1mw Tas2r145 Cxcl11 Tas2r119 Tas2r118 Tas2r117 Pde1b Sstr5 Tas2r107 Npbwr1 Tas2r108 Pyy Tas2r105 Pnoc Tas2r106 Akr1c2 Ccl5 Tas2r129 Npy2r Tas2r109 Tas2r136 Akr1c3 Tas2r137 Tas1r1 Oprm1 Tas2r135 Mchr1 Sstr1 Tas2r13 Aplnr Tas2r130 Sstr4 Tas1r3 Sstr2 Tas2r139 Npy1r Apln Apob Bdkrb1 Apoc2 Bdkrb2 Apoe Apoa2 Rln3 Npb Ppy Ccl1 Npw Gng10 Npy Akr1c1 Agrn Gpihbp1 Sstr3 Penk C5ar1 Kng1 Kng2 Cxcr5 Npy5r Nmur2 Cxcr6 Oprd1 Psap Oxgr1 Sdc2 Sdc3 Sdc4 Ccr1 Ccr1l1 Ptgdr2 Sucnr1 Adcy8 Awat2 Adcy9 Adcy5 Adcy4 Adcy7 Adcy6 Prkar1b Adra2b Prkar1a Ttr Cxcr2 RGD1564865 Hebp1 Fpr-rs6 Nmu Fpr-rs3 Pf4 Fpr2 Fpr3 Anxa1 Pmch Gnal Fpr-rs4 Rxfp3 Lpar5 Gnat3 S1pr1 S1pr5 S1pr4 S1pr3 Ppp2cb Ppp2ca Cx3cr1 Lpar1 Lpar3 Ppp2r1a Lpar2 Sst S1pr2 Ackr3 Cxcl9 Cxcl6 Cx3cl1 Gpr31 Ccl9 Cxcl2 Rgr Cxcl1 Ccl6 Gpr18 Gpr55 Gpsm3 Htr5a Gpsm2 Cxcl3 Agt Gpsm1 Gnb3 Cnr2 Gnb5 Ccl4 Opn3 Ppp2r1b Gnb2 Cnr1 Gnb1 Htr1d Gng13 Htr1f Gng12 Htr1a Gng11 Mapk1 Htr1b Hrh4 Prkaca Ptger3 Prkacb Adora3 Gpr183 Agtr2 Mtnr1a Opn5 Galr1 Pcp2 LOC100912034 Hcar1 Gnb4 Oprk1 Hcar2 Camk4 Gng4 Gngt2 LOC100911796 Drd4 Gng5 LOC100363178 Drd2 Gngt1 Adora1 Gng8 LOC100365814 Gng3 Fpr1 Pla2g4a Chrm2 Gabbr1 Gabbr2 C3ar1 Prkcd P2ry4 Gpr17 Cxcl12 Adcy3 Prkar2b Prkar2a P2ry12 Cxcr4 P2ry13 Adra2a Gnai2 Adra2c Rbp4 Lrp1 C3 Lrp10 Rbp2 Ppbp Tex12 Rbp1 Lrp8 Apom Lrp12 Lpl Bco1 Rdh11 Lrat Bco2 Adrbk1 Gnai1 Cyp4v3 TRANSMISSION ACROSS CHEMICAL SYNAPSES%REACTOME%R-RNO-112315.1 Transmission across Chemical Synapses Plcb1 Slc6a11 Slc6a13 Slc6a1 Cacna1e Slc6a12 Mdm2 Raf1 Plcb3 Rims1 Cplx1 Syt1 Vamp2 Stxbp1 Ppfia1 Ppfia2 Ppfia3 Ppfia4 Ap2a2 Adcy8 Adcy9 Gad2 Adcy5 Adcy4 Adcy7 Adcy6 Slc38a2 Gad1 Abat Aldh5a1 Gabrr1 Maoa Gabrr3 Gabrr2 Slc22a1 Slc22a2 Aldh2 Comt Slc6a4 Slc6a3 Bche Lrtomt Chat Gnai3 Ache Slc1a3 Gnal Slc1a7 Rab3a Slc1a6 Slc1a1 Gnat3 Prkcb Nsf Ap2s1 Bzrap1 Ap2a1 Myo6 Ap2m1 Camkk1 Kcnj16 Gnb3 Gnb5 Gnb2 Gnb1 Chrne Gng13 Chrnd Gng12 Mapk1 Gng11 Cacnb4 Stx1a Cacng8 Cacnb1 Cacnb2 Creb1 Cacna2d3 LOC100912034 Prkca Gnb4 Cacng2 Cacng3 Camk4 Gng4 Cacna2d2 Cacng4 Slc5a7 Gngt2 Gng5 Gngt1 Gng8 Dlg4 Gng3 Grin2d Camk2g Grin2b Grin1 Chrnb4 Nefl Rasgrf1 Dlg1 Dlg2 Glra4 Dlg3 Htr3b Camk2d Htr3a Actn2 Camk2a Glrb Lin7c Rps6ka2 Lin7a Rps6ka1 Syn3 Syn2 Rps6ka3 Chrna4 Chrna5 Chrna9 Chrna6 Chrnb2 Chrna7 Chrnb3 Syn1 Chrna2 Apba1 Chrna3 Chrna1 Kcnj2 Kcnj3 Kcnj15 Glul Kcnj9 Kcnj5 Cacna1b Gabbr1 Kcnj12 Gng10 Gabbr2 Rras Kcnj4 Kcnj6 Gria3 Gria4 Grip1 Grip2 Pick1 Lrrc7 Adcy3 Akap5 Slc32a1 Slc38a1 Lin7b Gabra5 Dnajc5 Gabra6 Gabrb1 Gabrg2 Gabra1 Gnai2 Gabra2 Grik1 Grik3 Grik2 Ncald Grik5 Slc17a7 Pdpk1 Naaa Rps6ka6 Hras Gnai1 Gabra4 Gabrb2 FGFR2 LIGAND BINDING AND ACTIVATION%REACTOME%R-RNO-190241.1 FGFR2 ligand binding and activation Fgf16 Fgf17 Fgf10 Fgf9 Fgfbp3 Fgfbp1 Fgfr2 Fgf7 Fgf2 Fgf8 Fgf23 Fgf22 Fgf4 Fgf1 Fgf3 Fgf6 Fgf5 Fgf20 SIGNALING BY NON-RECEPTOR TYROSINE KINASES%REACTOME DATABASE ID RELEASE 66%10146199 Signaling by Non-Receptor Tyrosine Kinases Ereg Nrg1 Kras Btc LOC100909609 LOC102552659 Erbb3 Erbb2 Pxn Srms Nrg3 Ptpn1 Stat3 Egfr Hbegf Cdk4 Akt1 Rac1 Arhgap35 Ptk6 Nrg4 Socs3 Ccnd1 Dok1 Ccne1 Cdk2 Arap1 Crk Cdkn1b Lrrk2 Bcar1 Stap2 Cbl Khdrbs2 Hif1a Gpnmb Khdrbs1 Khdrbs3 Rhoa Dock1 Erbb4 Hras Nras Elmo2 Rasa1 Nrg2 CARDIAC CONDUCTION%REACTOME%R-RNO-5576891.1 Cardiac conduction Stim1 Dmpk Sri Tnni3 Kcnd3 LOC100911951 Kcnd1 Kcnip3 Kcnip4 Kcnip2 Akap9 Kcnk16 Slc8a3 Ahcyl1 Slc8a2 Slc8a1 Cacna1c Cacng7 Cacna1d Cacng1 Kcne1 Kcne2 Kcnk5 Cacng5 Kcnk6 Kcne4 Kcnk7 Scn2a Scn7a Scn4b Scn2b Fgf11 Scn9a Fgf12 Fgf13 Scn10a Scn4a Nos1 Scn5a Fgf14 Scn3a Scn11a Rangrf Scn1b Kcne3 Prkaca Cacnb4 Itpr1 Cacnb1 Cacng8 Cacnb2 Kcnq1 Itpr3 Cacna2d3 Cacna1f Kcne5 Cacng2 Cacna1s Cacng3 Cacna2d2 Cacng4 Cacna2d4 Camk2g Atp2b4 Kcnh2 Atp2b2 Atp2b1 Camk2d Camk2a Clic2 Trdn Atp2a2 Pln Atp2a3 Kcnj2 Kcnj11 Kcnj14 Kcnk1 Kcnk12 Kcnk13 Kcnk2 Kcnk3 Npr2 LOC100909725 Npr1 Kcnk4 Nppc Kcnk10 Kcnj12 Nppa Kcnk9 Corin Abcc9 Kcnk15 Fxyd2 Kcnj4 Fxyd3 Fxyd4 Sln Fxyd6 Fxyd7 Atp1b3 Atp1b2 Atp1b1 Fkbp1b Ryr2 Kcnk18 Atp1a4 Atp1a1 Atp1a2 Atp1a3 TBC RABGAPS%REACTOME DATABASE ID RELEASE 66%10146222 TBC RABGAPs Rab6b Rabgap1 Rab35 Rab7a Ulk1 Rab8a Rab8b Gabarapl2 Tsc1 Tbc1d10a Tbc1d10b Rab11a Arf6 Rab6a Tsc2 Rab7b Tbc1d13 Tbc1d16 Tbc1d15 Tbc1d17 Sytl1 Rab33a Rab11b Rab33b Tbc1d2 Tbc1d7 Optn Tbc1d25 Tbc1d10c Gabarap Rab4a Tbc1d14 FBXL7 DOWN-REGULATES AURKA DURING MITOTIC ENTRY AND IN EARLY MITOSIS%REACTOME%R-RNO-8854050.1 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis Psmc6 Psmb10 G6pc Psmb8 Psmb9 Psmb4 Psmb11 Fbxl18 Psmb5 Fbxl7 Psmf1 Psmb6 Psmd4 Psmb2 Rbx1 Cul1 Psmd5 Psmd8 Psmb7 Psmd9 Psmb1 Psmb3 Psma8 Skp1 Psmd11 Psmd12 Psmd13 Aurka Psmd14 Psma5 Psma2 Psmc5 Psmc3 Psmd2 Psma1 Psma4 Psmc1 Psma3 Psmc4 Psmc2 Psma6 Psme1 Psmd1 Psme2 Psmd7 LOC100909844 Psmd3 Psmd6 COPI-INDEPENDENT GOLGI-TO-ER RETROGRADE TRAFFIC%REACTOME%R-RNO-6811436.1 COPI-independent Golgi-to-ER retrograde traffic Dctn1 Dctn2 Pla2g6 Dync1li2 Rab6b Dctn3 Dync1i2 Rab18 Rab3gap2 Pla2g4a Bicd2 Bicd1 Capzb Actr10 Dync1h1 Pafah1b1 Agpat3 Dync1li1 Capza2 Capza3 Rab6a Dynll2 Dctn5 Dctn6 Dync1i1 Dctn4 Galnt1 Actr1a Pafah1b3 Galnt2 TANDEM PORE DOMAIN HALOTHANE-INHIBITED K+ CHANNEL (THIK)%REACTOME DATABASE ID RELEASE 66%10145843 Tandem pore domain halothane-inhibited K+ channel (THIK) Kcnk13 PYROPHOSPHATE HYDROLYSIS%REACTOME%R-RNO-71737.1 Pyrophosphate hydrolysis Sar1a Ppa2 MITOPHAGY%REACTOME DATABASE ID RELEASE 66%10146046 Mitophagy Csnk2b Src Vdac1 Pgam5 Fundc1 Mfn1 Mfn2 LOC100911485 Tomm6 Csnk2a2 Tomm70a Tomm7 Tomm40 Ulk1 Sqstm1 Atg12 Map1lc3a Pink1 Mterfd1 Csnk2a1 Tomm20 Tomm22 LYSOSOMAL OLIGOSACCHARIDE CATABOLISM%REACTOME DATABASE ID RELEASE 66%10146170 Lysosomal oligosaccharide catabolism Man2b1 Manba Man2c1 POTASSIUM CHANNELS%REACTOME%R-RNO-1296071.1 Potassium Channels Kcng4 Kcng3 Kcnq2 Kcna7 Kcnb2 Kcns2 Kcnq3 Kcns1 Kcnh4 Kcnmb4 Kcnh3 Kcnmb3 Kcnh2 Kcnn2 Kcnab3 Kcnn3 Kcna10 Kcnf1 Kcnh6 Kcnmb2 Kcnh5 Kcnmb1 Kcnd3 Kcnn4 Kcnn1 Kcnd1 Kcnma1 Kcna1 Kcna2 Kcna5 Kcnc3 Kcnh1 Kcna4 Hcn1 Hcn3 Kcnk16 Hcn2 Kcnj2 Kcnj3 Kcnj11 Kcnj14 Kcnk1 Kcnj15 Kcnj9 Kcnk13 Abcc8 Kcnk2 Kcnk3 Kcnj5 LOC100909725 Kcnj8 Gabbr1 Kcnk4 Kcnj12 Kcnk10 Gabbr2 Kcnk9 Gng10 Abcc9 Kcnj4 Kcnj6 Kcnk6 Kcnk7 Kcnab2 Kcnj16 Gnb3 Kcnc2 Gnb2 Gnb1 Kcnk18 Kcnv2 Gng12 Kcnv1 Kcns3 Kcnq1 Gng4 Gngt2 Gng5 Gngt1 Gng8 Gng3 PI3K CASCADE%REACTOME DATABASE ID RELEASE 66%10144954 PI3K Cascade Pik3r1 Pik3r2 Fgf23 Fgf22 Fgf4 Fgf1 Fgf3 Tlr9 Fgf6 Fgf5 Fgf20 Gab1 Pde3b Fgf16 Pik3c3 Fgf17 Irs2 Fgf10 Fgf9 Fgfr2 Fgf7 Fgf2 Fgf8 Fgfr3 Pik3r4 Trib3 Pdpk1 Fgfr1 Fgfr4 Pik3cb Ptpn11 Fgf19 Them4 Irs1 Frs2 Akt2 Grb2 BREAKDOWN OF THE NUCLEAR LAMINA%REACTOME%R-RNO-352238.1 Breakdown of the nuclear lamina Casp6 Lmnb1 Lmna ACTIVATION, TRANSLOCATION AND OLIGOMERIZATION OF BAX%REACTOME DATABASE ID RELEASE 66%10145017 Activation, translocation and oligomerization of BAX Bax Bid ENDOSOMAL VACUOLAR PATHWAY%REACTOME%R-RNO-1236977.1 Endosomal Vacuolar pathway RT1-CE2 RT1-CE3 RT1-CE4 RT1-A2 RT1-CE7 RT1-M3-1 RT1-CE5 RT1-A1 B2m RT1-M6-1 LOC683761 RT1-CE10 LOC100364956 RT1-M2 RT1-M6-2 LOC100364500 RT1-M5 RT1-M4 RT1-S3 RT1-A ABACAVIR METABOLISM%REACTOME%R-RNO-2161541.1 Abacavir metabolism Nt5c2 Adal Adh6 PROTEIN FOLDING%REACTOME%R-RNO-391251.1 Protein folding Cct6b Gnai3 Rgs9 Csnk2a2 Gnat3 Gnao1 Cct6a Csnk2a1 Tcp1 Cct7 Rgs7 Cct4 Gnat2 Pdcl Gnaz Cct3 Csnk2b Gnai2 Gnb3 Gnb5 Cct2 Gnb2 Gnb1 Gng13 Gng12 Gng11 Gnat1 Cct8 LOC100912034 Gnb4 Gng4 Gngt2 Gnai1 Gng5 Gngt1 Gng10 Gng8 Gng3 ACTIVATION OF BIM AND TRANSLOCATION TO MITOCHONDRIA%REACTOME DATABASE ID RELEASE 66%10145048 Activation of BIM and translocation to mitochondria Mapk8 Bcl2l11 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION%REACTOME%R-RNO-399955.1 SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion Pip5k1c Plxna2 Fyn Plxna1 Tln1 Nrp1 Sema3a Farp2 SIGNALING BY NTRKS%REACTOME%R-RNO-166520.1 Signaling by NTRKs Dusp3 Dusp4 Rac1 Vrk3 Rps6ka2 Rps6ka1 Rps6ka3 Rps6ka5 LOC100912585 Dusp7 Dusp6 Atf1 Furin Gab1 Ap2a2 Irs2 Dnal4 Hgf Ralgds Kidins220 Sh3gl2 Irs1 Frs2 Kras Src Pik3r1 Pik3r2 Shc2 Dock7 Cltc Clta Ntrk1 Ngf Ppp2cb Ntf4 Ppp2ca Ntrk2 Bdnf Ppp2r1a Ap2s1 Ap2a1 Ap2m1 Shc3 Mapk7 Crk Rap1a Ppp2r1b Mapkapk3 Mapkapk2 Mapk1 Pik3cb Rhoa Creb1 Plcg1 Crkl Hras Pcsk6 Ntrk3 Nras Ntf3 Sos1 Mapk14 Rapgef1 Shc1 Pcsk5 Mapk11 Grb2 LOC100911248 HUR (ELAVL1) BINDS AND STABILIZES MRNA%REACTOME DATABASE ID RELEASE 66%10145693 HuR (ELAVL1) binds and stabilizes mRNA Prkcd RGD1563307 Xpo1 Prkca Elavl1 Anp32a Tnfsf13 INTESTINAL LIPID ABSORPTION%REACTOME DATABASE ID RELEASE 66%10145460 Intestinal lipid absorption Npc1l1 RNA POLYMERASE I PROMOTER OPENING%REACTOME DATABASE ID RELEASE 66%10144847 RNA Polymerase I Promoter Opening LOC100910200 H2afx Hist1h4b LOC684841 Hist1h2bh LOC100912290 Hist1h2ail1 Hist1h4m LOC102549173 LOC103690002 LOC100910152 LOC100912338 Ubtf Hist1h3c H2afb3 Hist1h3f Hist2h4 LOC684819 Hist1h3a H2afj Hist2h2aa3 Hist1h2bq Hist2h2aa2 LOC100364835 LOC684762 Hist1h2bo Hist1h2bcl1 Hist2h3c2 Hist1h2bk H3f3b Hist1h2bg Mbd2 LOC680097 LOC684797 LOC100912418 Hist1h2ba Hist3h2bb INTEGRIN CELL SURFACE INTERACTIONS%REACTOME%R-RNO-216083.1 Integrin cell surface interactions Cd44 Ibsp Itgam Itgae Itgb6 Itgb7 Itgb8 Madcam1 Itgb2 Itga4 Vtn Itga6 Jam3 Itga8 Fbn1 Col16a1 Cd47 Col9a1 Col9a2 Col9a3 Col4a1 Fgb Fgg Thbs1 Col4a2 Col4a3 Fga Itgal Itgax Spp1 Icam4 Icam5 Bsg Col13a1 Icam1 Vcam1 Lum F11r Comp Itga10 Itga11 Cdh1 Fn1 LOC100909977 Col18a1 Kdr Itga3 LOC100911572 Itga2b Icam2 TNFR2 NON-CANONICAL NF-KB PATHWAY%REACTOME DATABASE ID RELEASE 66%10145373 TNFR2 non-canonical NF-kB pathway Psmc6 Psmb10 Psmb8 Psmb9 Psmb4 Cd40 Psmb11 Psmb5 Psmf1 Psmb6 Psmd4 Psmb2 Cul1 Psmd5 Psmd8 Psmd9 Psmb3 Psma8 Psmd11 Psmd12 Psmd13 Psmd14 Tnf Cd40lg Ube2m Traf3 Psmc3 Tnfsf13b Tnfrsf9 Birc3 Tnfrsf8 Birc2 Edaradd G6pc Tnfrsf4 Eda2r Cd70 Tnfrsf17 Tnfsf8 Tnfrsf14 Tnfsf9 Tnfrsf25 Edar Psmb7 Prmt2 Tnfrsf11b Psmb1 Tnfrsf11a Tnfsf4 Tnfsf14 Tnfsf12 Skp1 Tnfrsf12a Tnfrsf13c Eda Tnfsf11 Lta Ltb Ltbr Cd27 Nfkb2 Psma5 Fbxw11 Tnfrsf1b Chuk Btrc Psma2 Psmc5 Psma1 Psmd2 Traf2 Uba3 Psma4 Map3k14 Psmc1 Relb Psma3 Psmc4 Psma6 Psmc2 Psme1 Psme2 Psmd1 Psmd7 Psmd3 Tnfsf13 Psmd6 N-GLYCAN TRIMMING AND ELONGATION IN THE CIS-GOLGI%REACTOME DATABASE ID RELEASE 66%10145771 N-glycan trimming and elongation in the cis-Golgi Man1c1 Manea Man1a2 Man1a1 Mgat1 FRS-MEDIATED FGFR4 SIGNALING%REACTOME DATABASE ID RELEASE 66%10146106 FRS-mediated FGFR4 signaling Kras Frs3 Fgf23 Fgf22 Fgf4 Fgf1 Fgf3 Fgf6 Fgf5 Fgf20 Fgf16 Fgf17 Fgf10 Fgf9 Fgfr2 Fgf7 Fgf2 Fgf8 Fgfr3 Fgfr1 Fgfr4 Ptpn11 Fgf19 Hras Nras Sos1 Frs2 Grb2 G-PROTEIN ACTIVATION%REACTOME%R-RNO-202040.1 G-protein activation Gnai3 Pomc Gnat3 Pdyn Gnao1 Gnat2 Gnaz Gnai2 Gnb3 Gnb5 Oprm1 Gnb2 Gnb1 Gng13 Gng12 Gng11 Gnat1 LOC100912034 Gnb4 Gng4 Gnai1 Gngt2 Gng5 Gngt1 Gng10 Gng8 Gng3 OXIDATIVE STRESS INDUCED SENESCENCE%REACTOME DATABASE ID RELEASE 66%10145165 Oxidative Stress Induced Senescence Map2k7 Map2k6 Mdm2 Map2k4 Tnik Mink1 Map3k5 Hist1h2bo Hist1h2bcl1 Scmh1 Hist2h3c2 Cbx4 Hist1h2bk Cbx2 H3f3b Cbx8 Cbx6 Bmi1 Rnf2 Kdm6b Ring1 Phc3 Mapkapk5 Cdkn2b Cdkn2c Cdk6 Eed LOC100910200 H2afx Hist1h4b LOC684841 Hist1h2bh LOC100912290 Rbbp7 Hist1h2ail1 Hist1h4m Cdk4 LOC102549173 LOC103690002 LOC100910152 LOC100912338 Hist1h3c Jun H2afb3 Hist1h3f Hist2h4 LOC684819 Hist1h3a H2afj Hist2h2aa3 Hist1h2bq Hist2h2aa2 LOC100364835 Phc1 LOC684762 Phc2 Mapk9 Mapk8 Fos LOC100910954 Txn1 Mdm4 Mapkapk3 Map4k4 Mapkapk2 Mapk1 Hist1h2bg Ezh2 LOC680097 LOC684797 Mapk14 LOC100912418 Hist1h2ba Hist3h2bb Mapk11 Mapk10 TACHYKININ RECEPTORS BIND TACHYKININS%REACTOME DATABASE ID RELEASE 66%10145521 Tachykinin receptors bind tachykinins Tacr3 Tacr2 Tac3 Tacr1 Tac1 GLOBAL GENOME NUCLEOTIDE EXCISION REPAIR (GG-NER)%REACTOME%R-RNO-5696399.1 Global Genome Nucleotide Excision Repair (GG-NER) Rfc1 Rfc2 Gtf2h1 Gtf2h2 Ddb2 Pole2 Pole4 Pias3 Pias1 Yy1 Ddb1 Mnat1 Rbx1 Actr8 Chd1l Actl6a Mcrs1 Cops8 Cops2 Actb Sumo1 Rpa3 Pole Sumo3 Ino80 Pcna Cul4b Ccnh Cul4a Ube2v2 Xpc Ube2n Xpa Ube2i Ruvbl1 Gtf2h3 Rfc5 Rfc4 Rfc3 Gtf2h5 Gtf2h4 Ercc5 Ercc3 Rpa1 Rpa2 Cops4 Cops6 Ercc2 Ercc1 Cops3 Ino80e Ino80d Nfrkb Usp45 Parp2 Parp1 Rad23a Cdk7 Rad23b Cops7b Cops7a Pold2 Pold1 Pold4 Ino80b Ino80c CENTROSOME MATURATION%REACTOME%R-RNO-380287.1 Centrosome maturation Dync1i2 Tubgcp2 Cep57 LOC691918 Haus3 Ninl Akap9 Ccp110 Dync1h1 Pafah1b1 LOC103692716 Dctn1 Cntrl Dctn2 Cep76 Pcm1 Cep78 LOC100911033 Cep164 Dctn3 Cep41 Ofd1 Sdccag8 Tubb5 Prkar2b Cenpj Ywhag Ppp2r1a Plk4 Ywhae LOC100912076 Tubg2 Haus2 Haus1 Haus5 Alms1 Cdk11b Haus4 Clasp1 Odf2 Tubb4a Cdk1 Nek2l1 Ssna1 Mapre1 Tubg1 Cep63 Prkaca Csnk1d Cep131 Tuba4a Cep250 Cep135 Csnk1e Ckap5 Cdk5rap2 Nme7 Tubgcp5 Pcnt Nek2 Tubgcp6 Cep72 Tubgcp3 Sfi1 Tubgcp4 Cep70 Actr1a Mzt1 Nedd1 Mzt2b CHROMATIN ORGANIZATION%REACTOME DATABASE ID RELEASE 66%10145803 Chromatin organization Kdm1a Phf20 Actl6a Mcrs1 Rps2 Setd6 Setd7 Setd8 Setd2 Setd3 Ash1l Suv39h1l1 Rbbp5 Jmjd6 Actl6b Hist1h2aa Smarce1 Pax3 Pbrm1 Arid1b Arid1a Cdk4 Brwd1 Smarcd1 Msl3l2 Smarcd2 Smarcd3 Brpf3 Ccnd1 Kdm2a Brpf1 Brd1 Kdm1b LOC100911453 RGD1310212 Wdr77 Kat6a Ing4 Ing5 Nfkb2 Nfkb1 Prmt3 Padi6 Prmt5 Prmt6 Prmt7 Rela Atf2 Hist1h2bo Kat7 Kansl3 Hist1h2bcl1 Hist2h3c2 Jade1 Hist1h2bk Jade3 Hat1 Kdm4b Carm1 Kdm4a Jade2 Kdm4d Kdm5a Kdm6b Kdm5d Smarca4 Kdm4dl1 Prmt1 Smarca2 LOC100911617 Kat8 Kdm8 Msl3 Kdm3b Kdm3a Arid2 Ogt Smarcc1 Smarcc2 Padi3 Coprs Smarcb1 Padi4 Msl1 Padi1 Ncoa1 Msl2 Meaf6 LOC100909949 Eed Whsc1 LOC100910200 Atf7ip H2afx Hist1h4b Prdm9 Wdr5 Kmt2a LOC684841 Hist1h2bh Smyd2 Setdb1 LOC100911180 LOC100912290 Suv420h2 Rbbp7 LOC686349 Hist1h2ail1 Suv420h1 Hist1h4m LOC102549173 Mecom LOC103690002 Ehmt2 LOC100910152 Whsc1l1 Dnmt3a Ehmt1 LOC100912338 Hist1h3c H2afb3 Hist1h3f Hist2h4 LOC684819 Hist1h3a H2afj Prdm16 Nsd1 Hist2h2aa3 Suv39h1 Hist1h2bq Suv39h2 Hist2h2aa2 LOC100910833 Ash2l Dot1l LOC100364835 Dpy30 LOC684762 Padi2 Ncoa2 Hist1h2bg Ezh2 LOC680097 LOC684797 LOC100912418 Hist1h2ba Hist3h2bb Aebp2 EXTENSION OF TELOMERES%REACTOME DATABASE ID RELEASE 66%10145111 Extension of Telomeres Rfc1 Rfc2 Rpa3 Pole2 Pole4 LOC100911727 Pole Pold2 Tert Pcna Pold1 Pold4 Rpa1 Slc25a16 Rpa2 Fen1 Prim2 Pola2 Prim1 Rfc5 Rfc4 Rfc3 Lig1 CDO IN MYOGENESIS%REACTOME DATABASE ID RELEASE 66%10145503 CDO in myogenesis Cdh2 Ctnna1 Myf5 LOC100909750 Myf6 Mapk12 Tcf4 Cdon Myog Cdc42 Boc Myod1 Mef2c Spag9 Cdh15 Mapk14 Mef2a Mapk11 Abl1 GAP JUNCTION TRAFFICKING AND REGULATION%REACTOME DATABASE ID RELEASE 66%10145298 Gap junction trafficking and regulation Gja1 Src Gja5 Dnm1 Gjd4 Gja3 Gja8 Gja4 Gjb6 Gjb2 Cltc Gja10 Cltb Gjd2 Gjb3 Clta Dnm2 Gjb4 Gjc1 Gjc2 Gjb1 Myo6 Dab2 Ap2m1 GLUTATHIONE SYNTHESIS AND RECYCLING%REACTOME%R-RNO-174403.1 Glutathione synthesis and recycling Ggct Gclm Cndp2 Gclc Ggt7 Ggt6 Chac2 Gss Chac1 Oplah INTERLEUKIN-3, INTERLEUKIN-5 AND GM-CSF SIGNALING%REACTOME DATABASE ID RELEASE 66%10145705 Interleukin-3, Interleukin-5 and GM-CSF signaling Stat5a Jak3 Csf2ra Csf2rb Il2rg Pik3r3 Pik3r1 Jak1 Pik3r2 Il5ra Inpp5d Ywhaz Pik3cd Vav1 Fyn Crk Cbl Prkaca Pik3cb Il5 Ptpn11 Tec Il2 Ptpn6 Lyn Il2ra Csf2 Crkl Il3ra Yes1 Sos1 Hck Rapgef1 Shc1 Syk Grb2 LOC100911248 Il2rb ACYL CHAIN REMODELLING OF PC%REACTOME%R-RNO-1482788.1 Acyl chain remodelling of PC Pla2r1 Pla2g6 Pla2g3 Pla2g5 Pla2g4e Pla2g4b Pla2g4d Pla2g16 Pla2g2a Pla2g2f Pla2g10 Pla2g2d Pla2g1b LOC686302 Pla2g4a Pla2g12a Pla2g4c Lpcat4 Lpcat1 Plbd1 Pnpla8 Lpcat3 Lpcat2 Tmem86b Pla2g4cl1 INTERLEUKIN-1 SIGNALING%REACTOME%R-RNO-9020702.1 Interleukin-1 signaling Ripk2 Psmc6 Map2k6 Ager Psmb10 Psmb8 Map3k8 Psmb9 Psmb4 Peli3 Nfkbib Psmb11 Psmb5 Psmf1 Peli2 Psmb6 Traf6 Psmd4 Psmb2 Cul1 Rbx1 Psmd5 Psmd8 Psmd9 Psmb3 App Psma8 Psmd11 Psmd12 Tab1 Psmd13 Rela Psmd14 Map3k7 Peli1 Irak2 Il1rap Psmc3 Sqstm1 Nfkbia Il1b LOC100910771 Ube2n Irak3 Il1r1 Map3k3 G6pc Psmb7 Psmb1 Skp1 Il1a Nfkb2 Nfkb1 Psma5 S100b Irak4 Dhx9 Fbxw11 Chuk Tollip Btrc Psma2 Psmc5 Nkiras1 Psma1 LOC100362142 Psmd2 Psma4 Nod1 Nod2 Psmc1 Psma3 Nkiras2 Psmc4 Psma6 Psmc2 Tab2 Psme1 Tab3 LOC100912618 Ube2v1 Psme2 Psmd1 Ikbkb Psmd7 Myd88 Tnip2 Psmd3 Psmd6 G0 AND EARLY G1%REACTOME%R-RNO-1538133.1 G0 and Early G1 Rbl2 Cdk2 E2f5 Rbl1 Lin9 Hdac1l E2f4 Hdac1 Dyrk1a Lin37 Lin52 Lin54 Ccna2 Ccne2 Ccna1 Ccne1 Tfdp1 Tfdp2 ACTIVATION OF CAMK IV%REACTOME%R-RNO-442745.1 Activation of CaMK IV Camk4 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%R-RNO-1296041.1 Activation of G protein gated Potassium channels Kcnj4 Kcnj6 Kcnj16 Gnb3 Gnb2 Gnb1 Gng12 Kcnj2 Kcnj3 Kcnj15 Kcnj9 Kcnj5 Gng4 Gngt2 Gabbr1 Gng5 Kcnj12 Gngt1 Gng10 Gng8 Gabbr2 Gng3 DUAL INCISION IN TC-NER%REACTOME%R-RNO-6782135.1 Dual incision in TC-NER Rfc1 Rfc2 Gtf2h1 Gtf2h2 Usp7 Pole2 Pole4 Ppie Ddb1 Mnat1 Rbx1 RGD1565904 Isy1 Polr2g Polr2h Polr2e Polr2f Polr2j Polr2k Polr2d Polr2i Polr2b Polr2c Polr2a Xab2 LOC100912534 Rpa3 Zfp830 Pole Prpf19 Tcea1 Pcna Cul4b Uvssa Ccnh Cul4a Hmgn1 Xpa Gtf2h3 Rfc5 Rfc4 Rfc3 Gtf2h5 Gtf2h4 Ercc5 Ercc8 Ercc3 Ercc6 Rpa1 Rpa2 LOC100911295 LOC100911822 Aqr Ercc2 Ercc1 Cdk7 Pold2 Pold1 Pold4 CYTOSOLIC TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 66%10144822 Cytosolic tRNA aminoacylation Sar1a ELECTRON TRANSPORT FROM NADPH TO FERREDOXIN%REACTOME%R-RNO-2395516.1 Electron transport from NADPH to Ferredoxin Fdx1l Fdxr Fdx1 VEGF LIGAND-RECEPTOR INTERACTIONS%REACTOME DATABASE ID RELEASE 66%10145339 VEGF ligand-receptor interactions Vegfa Flt4 LOC100911280 Kdr Flt1 Figf Vegfc Vegfb Pgf YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION%REACTOME%R-RNO-2032785.1 YAP1- and WWTR1 (TAZ)-stimulated gene expression Yap1 Tbx5 Tead2 Tead1 Wwtr1 DNA REPAIR%REACTOME DATABASE ID RELEASE 66%10144763 DNA Repair Rfc1 Rfc2 Gtf2h1 Gtf2h2 Usp7 Ddb2 Pole2 Pole4 Pias3 Polh Pias1 Spidr Ppie Eme2 Yy1 Eme1 Ddb1 Polq Mnat1 Rtel1 Ppp4r2 Rbx1 RGD1565904 Ppp4c Actr8 Isy1 Uba7 Polr2g Polr2h Polr2e Polr2f Polr2j Polr2k Pias4 Polr2d Polr2i Ube2l6 Polr2b Polr2c Chd1l Uimc1 Polr2a Actl6a Mcrs1 Xab2 Cops8 LOC100912534 Cops2 LOC100909750 Actb Sumo1 Rpa3 Lig3 Zfp830 Pole Prpf19 Sumo3 Ino80 Tcea1 Pcna Cul4b Xrcc3 Brca1 Uvssa Blm Ccnh Slx4 Mdc1 Cul4a Mus81 Ube2v2 Hmgn1 Slx1b Palb2 Xpc Sirt6 Ube2n Pms2 Gen1 Xpa Mlh1 Ube2i Msh6 Ruvbl1 Gtf2h3 Rfc5 Rfc4 Rfc3 Gtf2h5 Gtf2h4 Tp53bp1 Rad52 Ercc5 Herc2 Ercc8 Xrcc4 Ercc3 Ercc6 Rpa1 Rpa2 LOC100911295 LOC100911822 Cops4 Rchy1 Aqr Cops6 Ercc2 Ercc1 Lig1 Cops3 Slc25a16 Fen1 Sprtn Nploc4 Ns5atp9 Zbtb32 Poli Usp43 Rev1 Xrcc6 Xrcc5 Usp10 Ufd1l Abl1 Ino80e Ino80d Nfrkb Usp45 Xrcc1 Parp2 Parp1 Rad23a LOC100911727 Cdk7 Rad23b Cops7b Cops7a Pold2 Pold1 Pold4 Tdp2 Lig4 Paxip1 Polm Nhej1 Prkdc Dclre1c Poll Ino80b Ino80c Rhno1 Msh3 Bard1 Msh2 Wrn Topbp1 Rbbp8 Rmi1 Rmi2 Rad51c LOC100911267 Ppp5c Rad51d Rad51 Wdr48 Brca2 Rad50 Bre Brcc3 Ccna2 Ccna1 Dtl Atm Atrip Cdk2 Rad18 RGD1564719 RGD1306926 Fance Fanca Fancf Ube2t Fancc Fancb Rad1 Fancl Atr Fanci Bap1 Usp1 Poln Dclre1a Rad17 Fan1 Xrcc2 Rad9a Nbn Rad9b Mre11a LOC100359600 Hus1 Babam1 Mapk8 Mad2l2 Rev3l Kpna2 Vcp Hist1h2bo Tdg Mpg Hist1h2bcl1 Neil1 Hist1h2bk Ogg1 Neil2 Kdm4b Mbd4 Kdm4a Smug1 Pnkp Polb Nthl1 Mutyh Isg15 Trim25 Adprhl2 Ung Smarca5 Parg Apex1 LOC100910200 Whsc1 H2afx Fto Alkbh5 Hist1h4b Rnf8 Hist1h2bh LOC100912290 Eya3 Apbb1 LOC686349 Eya2 Hist1h4m Eya4 LOC100912338 Hist2h4 Hist1h2bq LOC100364835 Baz1b Fam175a LOC100910954 Chek2 Hist1h2bg LOC680097 LOC684797 LOC100912418 Hist1h2ba Hist3h2bb REGULATION OF NECROPTOTIC CELL DEATH%REACTOME DATABASE ID RELEASE 66%10146017 Regulation of necroptotic cell death Faslg Traf2 Cflar Fadd Birc3 Birc2 Ripk1 Xiap Tradd Tnfsf10 Casp8 Fas INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1%REACTOME DATABASE ID RELEASE 66%10145013 Inhibition of replication initiation of damaged DNA by RB1 E2F1 Ppp2cb Ppp2ca Ppp2r3b Ppp2r1a Rb1 Prim2 Pola2 Ppp2r1b Prim1 RECOGNITION OF DNA DAMAGE BY PCNA-CONTAINING REPLICATION COMPLEX%REACTOME DATABASE ID RELEASE 66%10146094 Recognition of DNA damage by PCNA-containing replication complex Rfc1 Rfc2 Rpa3 Pole2 Pole4 Rad18 Pole Wdr48 Ddb1 Pold2 Rbx1 Pcna Pold1 Cul4b Pold4 Zbtb32 Usp1 Cul4a Rpa1 Rpa2 Rfc5 Rfc4 Dtl Rfc3 SYNAPTIC ADHESION-LIKE MOLECULES%REACTOME DATABASE ID RELEASE 66%10146209 Synaptic adhesion-like molecules Grin2d Ptprd Grin2b Grin1 Dlg1 Gria3 Gria4 Flot1 Flot2 Rtn3 Dlg3 Ptprf Lrfn2 Lrfn3 Lrfn1 Lrfn4 Dlg4 VEGF BINDS TO VEGFR LEADING TO RECEPTOR DIMERIZATION%REACTOME DATABASE ID RELEASE 66%10145338 VEGF binds to VEGFR leading to receptor dimerization Vegfa Flt4 LOC100911280 Kdr Flt1 Figf Vegfc Vegfb Pgf THE ACTIVATION OF ARYLSULFATASES%REACTOME DATABASE ID RELEASE 66%10145887 The activation of arylsulfatases Arsi Arse Arsg Arsk Sts Arsb Arsa Sumf2 Sumf1 LINOLEIC ACID (LA) METABOLISM%REACTOME DATABASE ID RELEASE 66%10145933 Linoleic acid (LA) metabolism Acsl1 Fads1 Elovl1 Elovl5 Elovl2 Elovl3 Abcd1 FORMATION OF ANNULAR GAP JUNCTIONS%REACTOME%R-RNO-196025.1 Formation of annular gap junctions Cltb Clta Gja1 Dnm2 Dnm1 Dab2 Ap2m1 Cltc CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM%REACTOME DATABASE ID RELEASE 66%10145886 Chondroitin sulfate dermatan sulfate metabolism Ncan Agrn Hexb Hexa Xylt2 Chst7 Chst9 Chst12 Chst11 Dcn B3gat1 B3gat3 Csgalnact1 Csgalnact2 B3gat2 Chst13 LOC102550316 Chst3 Hyal1 Cspg5 Cspg4 Sdc2 Sdc3 Idua Sdc4 Ust Chst15 Chst14 Dsel Gpc6 Bcan Vcan Chpf2 Chsy1 Dse Gpc4 Gpc2 Arsb LOC100910284 B4galt7 Gpc1 Chpf B3galt6 INTERLEUKIN-12 FAMILY SIGNALING%REACTOME%R-RNO-447115.1 Interleukin-12 family signaling P4hb Il23a Crlf1 Stat1 Il6st Jak1 Stat3 Il12rb1 Il12rb2 Il12b Canx Il12a Il23r Tyk2 Ebi3 Vamp7 Il27ra TOLL LIKE RECEPTOR 10 (TLR10) CASCADE%REACTOME%R-RNO-168142.1 Toll Like Receptor 10 (TLR10) Cascade Map2k7 Ripk2 Map2k6 Ager Dusp3 Map2k4 Map3k8 Dusp4 Peli3 Nfkbib LOC100912399 Peli2 Map3k1 Traf6 Cul1 Vrk3 Rps6ka2 Rps6ka1 App Rps6ka3 Rps6ka5 LOC100912585 Tab1 Dusp7 Dusp6 Rela Atf1 Atf2 Map3k7 Peli1 Irak2 Nfkbia LOC100910771 Ube2n Jun Ppp2cb Ppp2ca Skp1 Ppp2r1a Nfkb2 Nfkb1 Mapk9 Mapk8 Fos S100b Mapk7 Dhx9 Fbxw11 Chuk Ppp2r1b Ecsit Mapkapk3 Btrc Mapkapk2 Mapk1 Nkiras1 LOC100362142 Nod1 Nod2 Nkiras2 Creb1 Tab2 Tab3 LOC100912618 Ube2v1 Ikbkb Mapk14 Myd88 Tnip2 Mapk11 Mapk10 BIOSYNTHESIS OF ASPIRIN-TRIGGERED D-SERIES RESOLVINS%REACTOME%R-RNO-9020265.1 Biosynthesis of aspirin-triggered D-series resolvins Gpx4 Alox5 Lta4h ADENYLATE CYCLASE INHIBITORY PATHWAY%REACTOME DATABASE ID RELEASE 66%10145186 Adenylate cyclase inhibitory pathway Gnat3 Adcy8 Adcy9 Gnai3 Adcy5 Adcy3 Adcy4 Gnai2 Adcy7 Adcy6 Gnal Gnai1 HYDROLYSIS OF LPC%REACTOME%R-RNO-1483115.1 Hydrolysis of LPC Pla2g4a LOC686302 Plbd1 Pla2g4c Pla2g4e Pla2g4b Pla2g4d Pla2g15 Pla2g4cl1 PRE-NOTCH EXPRESSION AND PROCESSING%REACTOME DATABASE ID RELEASE 66%10145916 Pre-NOTCH Expression and Processing Notch1 Prkci Tmed2 Notch2 Notch4 Elf3 Notch3 Furin CD22 MEDIATED BCR REGULATION%REACTOME DATABASE ID RELEASE 66%10146141 CD22 mediated BCR regulation Ptpn6 Cd79al Lyn Cd22 Cd79b Cd79a ACTIVATION OF NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%R-RNO-629602.1 Activation of Nicotinic Acetylcholine Receptors Chrnb4 Chrne Chrnd Chrna4 Chrna5 Chrna9 Chrna6 Chrnb2 Chrna7 Chrnb3 Chrna2 Chrna3 Chrna1 TRANSCRIPTION FROM MITOCHONDRIAL PROMOTERS%REACTOME DATABASE ID RELEASE 66%10145118 Transcription from mitochondrial promoters Polrmt Tfam Tfb2m Mterf DOPAMINE RECEPTORS%REACTOME%R-RNO-390651.1 Dopamine receptors Drd5 Drd1 Drd4 Drd2 SYNTHESIS OF EPOXY (EET) AND DIHYDROXYEICOSATRIENOIC ACIDS (DHET)%REACTOME DATABASE ID RELEASE 66%10145947 Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) Cyp2c7 Cyp1b1 LOC100361547 Cyp1a1 Ephx2 Cyp1a2 Cyp2j10 Cyp2c6v1 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK%REACTOME DATABASE ID RELEASE 66%10145383 Energy dependent regulation of mTOR by LKB1-AMPK Cab39l Lamtor3 RragB Strada Prkab1 Stradb Prkab2 Cab39 Mtor Rheb Prkag3 Lamtor2 Rptor Lamtor1 Lamtor4 Tsc1 Lamtor5 Mlst8 Prkaa1 Tsc2 Rraga Prkaa2 Rragc Rragd Slc38a9 BIOSYNTHESIS OF E-SERIES 18(S)-RESOLVINS%REACTOME%R-RNO-9018896.1 Biosynthesis of E-series 18(S)-resolvins Hpgd Gpx4 Alox5 Alox15 Lta4h SYNTHESIS OF PA%REACTOME DATABASE ID RELEASE 66%10144907 Synthesis of PA Ddhd2 Ddhd1 Pla2r1 Pld1 Pld2 Pla2g5 Pld6 Pla2g4b Pla2g4d Pla2g2a Pla2g2f Pla2g2d Pla2g10 Gpd1l Pla2g1b Pla2g4a Pla2g12a Fam73b Alppl2 Lpcat4 Agpat1 Alpp Agpat4 Lpcat1 Alpi Agpat3 Lipi Agpat9 Agpat6 Acp6 Agpat5 Gpd1 Gpam Gnpat Agpat2 Lclat1 Gpat2 Gpd2 NOSTRIN MEDIATED ENOS TRAFFICKING%REACTOME%R-RNO-203641.1 NOSTRIN mediated eNOS trafficking Nos3 Dnm2 Nostrin Wasl DEPYRIMIDINATION%REACTOME DATABASE ID RELEASE 66%10144972 Depyrimidination Tdg Neil1 Ogg1 Neil2 Mbd4 Smug1 Ung Nthl1 PHYSIOLOGICAL FACTORS%REACTOME%R-RNO-5578768.1 Physiological factors Npr2 Npr1 Nppc Nppa Corin JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1%REACTOME%R-RNO-450321.1 JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 Map2k7 Ripk2 Mapk9 Mapk8 Map2k4 Traf6 LOC100362142 Nod1 Nod2 LOC100910771 Tab2 Ube2n Tab3 Tab1 LOC100912618 Ube2v1 Map3k7 Mapk10 Irak2 DNA STRAND ELONGATION%REACTOME%R-RNO-69190.1 DNA strand elongation Rfc1 Rfc2 Rpa3 LOC100911727 Pold2 Pcna Pold1 Pold4 Rpa1 Slc25a16 Rpa2 Fen1 Prim2 Pola2 Prim1 Rfc5 Gins3 Rfc4 Gins4 Rfc3 Lig1 Gins1 Gins2 INTERFERON ALPHA BETA SIGNALING%REACTOME%R-RNO-909733.1 Interferon alpha beta signaling Irf9 Stat1 Jak1 Stat2 Ptpn1 Rnasel Abce1 Socs3 Socs1 Ifnar2 Ifna5 Ifna4 Ptpn11 LOC100912356 LOC100911527 Ifna11 Ptpn6 Usp18 LOC100912859 Ifnar1 RGD1560539 Ifna2 Ifnb1 LOC103690314 Tyk2 LOC100912314 Ifna16l1 RGD1565911 RGD1561827 TOLL-LIKE RECEPTOR CASCADES%REACTOME DATABASE ID RELEASE 66%10145131 Toll-like Receptor Cascades Cnpy3 Unc93b1 Tlr3 RGD1308751 Cts8l1 Ube2n Rbsn Lbp Ptpn4 Jun Ppp2cb Ppp2ca Skp1 Ppp2r1a Ticam2 Nfkb2 Nfkb1 Tlr7 MGC114246 Mapk9 Tlr8 Mapk8 Fos S100b Irak4 Mapk7 Dhx9 Fbxw11 Chuk Ppp2r1b Ecsit Eea1 Mapkapk3 Btrc Mapkapk2 Mapk1 Nkiras1 LOC100362142 Testin Nod1 Nod2 Nkiras2 Creb1 Tab2 Tab3 LOC100912618 Ube2v1 Ikbkb Mapk14 Myd88 Tnip2 Mapk11 Mapk10 Tlr2 Map2k7 Ripk2 Tbk1 Itgam Map2k6 Ager Dusp3 Irf3 Map2k4 Map3k8 Dusp4 Peli3 Nfkbib Lgmn LOC100912399 Peli2 Map3k1 Traf6 Cul1 Vrk3 Rps6ka2 Itgb2 Hsp90b1 Rps6ka1 App Rps6ka3 Rps6ka5 Bpi Tirap Tlr9 LOC100912585 Tab1 Dusp7 Dusp6 Rela Atf1 Atf2 Map3k7 Peli1 Irak2 Tlr4 Ikbke RGD1565355 Tank Traf3 LOC100364523 Apob Nfkbia LOC100910771 LOC685953 Cd36 Tlr6 Tlr10 Ctsb Ctsl Ctsm Ctsj RGD1564657 Ctsk Ctsq Ctsr Cd14 Pik3c3 Pik3r4 Dhx36 Ptpn11 Cts8 Cts7 RGD1564827 RESOLUTION OF SISTER CHROMATID COHESION%REACTOME DATABASE ID RELEASE 66%10145894 Resolution of Sister Chromatid Cohesion Cenpn Zwilch Cenpl Nup43 Cenpo Nup98 Nup133 Dync1li2 Nup107 Cenpt Cenpu Bub3 Bub1 Spdl1 Kntc1 Dync1i2 Mad1l1 LOC100910252 Stag1 Cenpk Cenph Nup37 Cenpi Pds5b Pds5a Cenpf Cdca5 Rad21 Cenpe Smc1a Cenpm Stag2 Ahctf1 Smc3 Ndel1 Cdca8 Dync1h1 Rcc2 Pafah1b1 Dync1li1 Rangap1 Mis12 Ppp1cc LOC100909468 Aurkb Dynll2 Ndc80 Sec13 Cenpc Xpo1 Cenpa Dync1i1 LOC100911204 Ranbp2 Spc24 Spc25 Hdac8 Birc5 Taok1 Itgb3bp Sgol2 Ppp2r5e Incenp Nsl1 B9d2 Cdc20 Kif2a Kif2c Kif2b Bub1b Kif18a Ppp2r5c Ppp2cb Ppp2r5a Ppp2ca Ppp2r1a Ppp2r5b Zwint Dsn1 Mad2l1 Nup85 Casc5 Clasp2 Ercc6l Nuf2 Clasp1 LOC679582 Ppp2r1b Cdk1 Mapre1 Pmf1 Ckap5 Ska2 Sgol1 Zw10 Ska1 GPVI-MEDIATED ACTIVATION CASCADE%REACTOME%R-RNO-114604.1 GPVI-mediated activation cascade Pik3r5 Pik3r1 Pik3r3 Pik3r2 Pik3r6 Rac1 Vav2 Vav1 Pik3cg Fyn Vav3 Fcer1g Pdpk1 G6b Cdc42 Pik3cb Ptpn11 Rhoa Ptpn6 Lat Rac2 Lyn Rhog Lcp2 Rhob Syk NADE MODULATES DEATH SIGNALLING%REACTOME DATABASE ID RELEASE 66%10145330 NADE modulates death signalling Ngf Casp3 Ngfr Casp2 Ngfrap1 Ywhae RHO GTPASES ACTIVATE RHOTEKIN AND RHOPHILINS%REACTOME DATABASE ID RELEASE 66%10146121 RHO GTPases Activate Rhotekin and Rhophilins Rtkn Tax1bp3 Rhoa Rhpn1 Rhpn2 Lin7b PROSTANOID LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145568 Prostanoid ligand receptors Ptger3 Ptgir Tbxa2r Ptgfr Ptgdrl Ptgdr Ptger2 Ptger1 Ptgdr2 PACKAGING OF TELOMERE ENDS%REACTOME%R-RNO-171306.1 Packaging Of Telomere Ends LOC100910200 H2afx Hist1h4b Hist1h2bh Acd LOC100912290 Pot1b Hist1h4m LOC103690002 LOC100910152 Pot1 LOC100912338 H2afb3 Hist2h4 H2afj Hist2h2aa3 Hist1h2bq Hist2h2aa2 LOC100364835 Hist1h2bo Tinf2 Hist1h2bcl1 Hist1h2bk Terf1 Terf2 Terf2ip Hist1h2bg LOC680097 LOC684797 LOC100912418 Hist1h2ba Hist3h2bb ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING%REACTOME DATABASE ID RELEASE 66%10145740 Advanced glycosylation endproduct receptor signaling App Ager S100b Capza2 TP53 REGULATES TRANSCRIPTION OF CELL DEATH GENES%REACTOME%R-RNO-5633008.1 TP53 Regulates Transcription of Cell Death Genes Triap1 Zfp420 LOC100911519 Chm Rabggta Prelid1 Rabggtb Cradd Bnip3l Slmo1 Pidd1 LOC100910137 Casp2 Atm FGFR2C LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 66%10145288 FGFR2c ligand binding and activation Fgf23 Fgf4 Fgf1 Fgf16 Fgf17 Fgf6 Fgf5 Fgf9 Fgfr2 Fgf2 Fgf8 Fgf20 PLASMA LIPOPROTEIN ASSEMBLY%REACTOME%R-RNO-8963898.1 Plasma lipoprotein assembly P4hb A2m Abca1 Zdhhc8 Prkaca Prkacb Sar1b Bmp1 Apoa1 Apob Apoc2 Apoe Apoc1 Apoa2 LOC100910181 Mttp Apoc4 ACTIVATED NTRK2 SIGNALS THROUGH FRS2 AND FRS3%REACTOME%R-RNO-9028731.1 Activated NTRK2 signals through FRS2 and FRS3 Ntf4 Ntrk2 Bdnf Frs2 Sos1 Grb2 E2F MEDIATED REGULATION OF DNA REPLICATION%REACTOME DATABASE ID RELEASE 66%10145014 E2F mediated regulation of DNA replication Ppp2cb Ppp2ca Ppp2r3b Ppp2r1a Rb1 Prim2 Pola2 Ppp2r1b Prim1 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE%REACTOME%R-RNO-181438.1 Toll Like Receptor 2 (TLR2) Cascade Map2k7 Ripk2 Map2k6 Ager Dusp3 Map2k4 Map3k8 Dusp4 Peli3 Nfkbib LOC100912399 Peli2 Map3k1 Traf6 Cul1 Vrk3 Rps6ka2 Rps6ka1 App Rps6ka3 Rps6ka5 Tirap LOC100912585 Tab1 Dusp7 Dusp6 Rela Atf1 Atf2 Map3k7 Peli1 Irak2 Nfkbia LOC100910771 Ube2n Jun Ppp2cb Ppp2ca Skp1 Ppp2r1a Nfkb2 Nfkb1 Mapk9 Mapk8 Fos S100b Mapk7 Dhx9 Fbxw11 Chuk Ppp2r1b Ecsit Mapkapk3 Btrc Mapkapk2 Mapk1 Nkiras1 LOC100362142 Nod1 Nod2 Nkiras2 Creb1 Tab2 Tab3 LOC100912618 Ube2v1 Ikbkb Mapk14 Myd88 Tnip2 Mapk11 Mapk10 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION%REACTOME%R-RNO-1474151.1 Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation Nos3 Pts Spr Prkg2 LOC103692716 Akt1 Gch1 Gchfr RHO GTPASES ACTIVATE NADPH OXIDASES%REACTOME DATABASE ID RELEASE 66%10146047 RHO GTPases Activate NADPH Oxidases Noxo1 Noxa1 Pik3c3 Ncf1 Rac2 Ncf4 Pik3r4 Nox3 Cybb Nox1 Rac1 Cyba DOWNREGULATION OF ERBB2:ERBB3 SIGNALING%REACTOME%R-RNO-1358803.1 Downregulation of ERBB2:ERBB3 signaling Akt3 Rnf41 Nrg1 LOC102552659 Erbb3 Erbb2 Akt1 Usp8 Akt2 Nrg2 CELL-CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 66%10145495 Cell-cell junction organization Pvrl3 Crb3 Pvrl4 PVR Pvrl1 Pard6a Cdh10 Cdh11 Cdh17 Cdh13 Cdh7 Cdh9 F11r Inadl Jup Cdh24 Pard6b Prkci Cadm3 Cadm2 Pard3 Mpp5 Ang2 Cdh1 Cdh2 Ctnna1 Pvrl2 Sdk2 Cdh3 Ctnnd1 Cdh5 Pard6g Cdh6 Cdh15 SYNTHESIS OF IPS IN THE NUCLEUS%REACTOME%R-RNO-1855191.1 Synthesis of IPs in the nucleus Ipmk Ip6k2 Ip6k1 Ippk SYNTHESIS OF DNA%REACTOME DATABASE ID RELEASE 66%10144719 Synthesis of DNA Rfc1 Psmc6 Rfc2 Psmb10 Psmb8 Pole2 Psmb9 Pole4 Psmb4 Psmb11 Psmb5 Psmf1 Psmb6 Psmd4 Psmb2 Rbx1 Psmd5 Psmd8 Psmd9 Psmb3 Psma8 Psmd11 Psmd12 Prim2 Ccna2 Ccne2 Pola2 Ccna1 Psmd13 Prim1 Ccne1 Psmd14 Mcm2 Mcm4 Mcm3 Cdk2 Mcm5 Rpa3 Mcm6 Pole Pcna Psmc3 Mcm8 Mcm7 Orc4 Orc5 Orc6 Orc1 Orc2 Orc3 Rfc5 Rfc4 Rfc3 Cdc6 Ube2d1 Rpa1 Rpa2 Skp1 Lig1 Anapc7 Cdc26 Cdc27 Cdc23 Ube2c Skp2 Anapc16 Cdc16 Anapc4 Anapc2 Anapc1 Slc25a16 Fen1 Cul1 Anapc11 Anapc15 Anapc10 Fzr1 G6pc Psmb7 Psmb1 Gins3 Gins4 Gins1 Gins2 Psma5 LOC100911727 Cdt1 Pold2 Psma2 Pold1 Pold4 Psmc5 Psma1 Psmd2 Psma4 Psmc1 Psma3 Psmc4 Psma6 Psmc2 Psme1 Psmd1 Psme2 Psmd7 Psmd3 Psmd6 SYNTHESIS OF BILE ACIDS AND BILE SALTS%REACTOME DATABASE ID RELEASE 66%10145312 Synthesis of bile acids and bile salts Nr1h4 Osbp Amacr Akr1d1 Cyp39a1 Ptgis Rxra Acot8 Osbpl3 Hsd17b4 Osbpl6 Osbpl9 Osbpl7 Slc27a5 Abcb11 Cyp7b1 Hsd3b7 Acox2 Akr1c2 Ncoa2 Ch25h Akr1c12l1 Akr1c3 Cyp7a1 Slc27a2 Baat Cyp46a1 Cyp8b1 Akr1c19 Akr1c13 Akr1c14 RGD1564865 Akr1c12 Ncoa1 Akr1c1 APOPTOTIC FACTOR-MEDIATED RESPONSE%REACTOME%R-RNO-111471.1 Apoptotic factor-mediated response Diablo LOC100360940 Xiap GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT%REACTOME%R-RNO-72706.1 GTP hydrolysis and joining of the 60S ribosomal subunit LOC100912571 Eif3l Eif2s3 Eif3m Eif3j Eif3k Rps20 Rps27l Eif3e Eif3f Eif3b Eif3a Eif3d Eif3c LOC100360573 Eif2s1 Eif2s2 Eif4g1 Rps4x LOC100359951 LOC100359593 Eif5 LOC100359503 LOC100362640 Rps3 Rps15a Rps2 Rps13 Rps12 LOC100911372 LOC100361854 LOC684988 LOC103689992 Rps5 Rps7 Rps6 Eif3g Eif3h Eif4a2 LOC100362830 Eif1ax Eif4a1 LOC100363012 LOC680559 LOC100911110 LOC100362149 Rps16 LOC100911431 Rps18 LOC100360679 Rps15 Eif4h Eif4b Rps3a INTRA-GOLGI AND RETROGRADE GOLGI-TO-ER TRAFFIC%REACTOME DATABASE ID RELEASE 66%10146192 Intra-Golgi and retrograde Golgi-to-ER traffic Kif21a Kif21b Kifc1 Kif3c Stx5 Pla2g6 Racgap1 Klc1 Kif22 Arf5 Dync1li2 Kif3b Copa Kif23 Kif18b Kifap3 Igf2r Kif11 Kif12 Kif4a Kif6 Kif1a Arf4 Dync1i2 Kif1c Man1c1 Gbf1 Kif27 Klc4 Kif9 Man1a1 Kif13b Cenpe Klc2 Klc3 Cog4 Cog6 Gcc1 Cog8 Cog3 Man2a1 Pafah1b1 Rhobtb3 Alpp Alpi Cog1 Man2a2 Cog2 Usp6nl Scoc Cog7 Kif3a LOC102555167 Dynll2 Stx6 Rab39a Copz2 Dync1i1 Copz1 Ykt6 Rabepk Vps45 Tmed7 Vps53 Tmed3 Vps52 Tmed2 Cux1 Arfip2 Vps54 Rab6b Rab9a Napg Ric1 Napb Copb1 Napa Rab3gap2 Tmed9 Bicd2 Bicd1 Nsf Alppl2 Golim4 Arl1 Agpat3 Kdelr1 Capza2 Arfrp1 Capza3 Rab6a Arcn1 Kif20b Kif16b Kif26a Kif20a Kif26b Kif19 Rab33b Kdelr2 Plin3 Galnt1 Rab9b Pafah1b3 Galnt2 Kdelr3 Bnip1 LOC100909548 Rab36 Tgoln2 Use1 Rab18 Rgp1 Pla2g4a Actr10 Stx16 Rab43 Stx18 Golga5 Dync1h1 Golga1 Golga4 Dync1li1 Copg1 Dctn5 Dctn6 Rab30 Cyth1 Cyth4 Cyth3 Rab1b Cyth2 Rab1a Trip11 Dctn4 Nbas Arfgap2 Dctn1 Dctn2 Arfgap3 Kif2a Arfgap1 Dctn3 Kif2c Kif2b Kif18a Capzb Kif5b Kif5a Sec22b Cope Snap29 Man1a2 M6pr Vamp4 Vamp3 Gosr2 Actr1a LOC100363782 Gosr1 Zw10 Tmed10 SIGNALING BY RECEPTOR TYROSINE KINASES%REACTOME DATABASE ID RELEASE 66%10144877 Signaling by Receptor Tyrosine Kinases Ptpn18 Ereg Rnf41 Nrg1 Btc LOC102552659 Erbb3 Cilp Erbb2 Abi1 Nrg3 Matk Egfr Abi2 Hbegf RGD1565904 Nrg4 Nos3 Polr2g Nck1 Polr2h Polr2e Polr2f Polr2j Rock2 Polr2k Polr2d Polr2i Polr2b Polr2c Polr2a Mknk1 Atp6v1g1 Atp6v1g2 Atp6v0a4 Esrp2 LOC100912534 Atp6v1b2 Esrp1 Rbfox2 Atp6v0a2 Fyn Atp6v1h Fgfrl1 Atp6v1f Tia1 Ncf1 Tial1 Stat6 Ncf4 Fgfbp3 Fgfbp1 Spry2 Pdgfc Pdgfd Yap1 Thbs4 Plat Ptk2 Cyfip2 Ptpn12 Nckap1 Usp8 Nck2 Nrg2 Sh2d2a Hspb1 Flt4 LOC100911280 LOC100909609 Flt1 Ptk2b Pxn Figf Shc2 Vegfc Nrp1 Dock7 Nrp2 Ranbp9 Vegfb Akt1 Axl Pgf Atp6v0d1 Atp6v1c2 Ntrk1 Atp6v0d2 Ngf Ntf4 Pdgfa Ntrk2 Pdgfb Bdnf Atp6v1a LOC100911822 Atp6v0e2 Atp6v0e1 Atp6v1g3 Cma1 Atp6v1e1 Prkcz Atp6v1e2 Atp6v1c1 Stub1 Kdr Crk Bcar1 Itga3 Vegfa Lama4 Plg Prkca Dock1 Lyn Ntrk3 Ctnnd1 Crkl Ntf3 Cdh5 Yes1 Elmo2 Rasa1 Lama1 Rapgef1 Galnt3 Shb LOC100911248 Dusp3 Dusp4 Mmp9 Frs3 Ptk6 Vrk3 Rps6ka2 Wwp1 Rps6ka1 Rps6ka3 Rps6ka5 Lamc1 Lamc2 LOC100912585 Dusp7 Dusp6 Atf1 Cyfip1 Col9a1 Col9a2 Brk1 Col9a3 Ptpn3 Col4a1 Arf6 Baiap2 Spint1 Gga3 Hgf Thbs1 Ptpn2 Stam2 Fes Pak2 Sh3gl2 Col4a2 Pak3 Sh3gl1 Pak1 Spint2 Sh3kbp1 Ptprk Muc20 Lamb1 Spry1 Nckap1l Hgfac Sh3gl3 Ranbp10 Tns4 Lamb2 Lrig1 Lamb3 Stam Rab4a Spp1 Wasf1 Arhgef7 Rock1 Pdgfra Pdgfrb Vav2 Atp6ap1 Vav1 Flrt1 Flrt2 Shc3 Atp6v0a1 Ctnna1 Mapk13 Mapk12 Csk Pik3c3 Dscam Vav3 Rap1a Pik3r4 Pdpk1 Cdc42 Spred1 Spred2 Ptpn6 Kit Kitlg Atp6v1d Aph1b Psenen Aph1a Ptpn1 LOC100911293 Psen2 Psen1 Rac1 Ncstn Furin Rictor Ap2a2 Fgf2 Dnal4 Diaph1 Ralgds Kidins220 Atp6v0c Src Pik3r3 Cltc Hnrnph1 Clta Ppp2cb Ppp2ca Ppp2r1a Prkcb Ap2s1 Rab4b Ap2a1 Ap2m1 Ncbp2 Mtor Ncbp1 Mapk7 Ppp2r1b Mlst8 Mapkapk3 Mapkapk2 Mapk1 Prkaca Akt3 Prkacb Creb1 Hnrnpm Sh2b2 Hnrnpf Mapk14 Mapk11 Stat5a Ptpru Eps15l1 Stat1 Stat3 Fgf23 Fgf22 Memo1 Fgf4 Grap Fgf1 Fer Fgf3 Tlr9 Fgf6 Fgf5 Fgf20 Gab1 Pde3b Gtf2f1 Igf2 Gtf2f2 Igf1 Fgf16 Fgf17 Irs2 Fgf10 Fgf9 Fgfr2 Fgf7 LOC103692716 Thbs2 Fgf8 Cbl Fgfr3 Cybb Trib3 Cyba Fgfr1 Fgfr4 Grb10 Esr1 Insr Ins1 Ins2 Fgf19 Erbb4 Them4 Irs1 Frs2 Akt2 Prkcd Kras Grb7 Pik3r1 Pik3r2 Tcirg1 Ptprj Jup Mapkap1 Pik3cb Ptpn11 Tec Rhoa Plcg1 Pcsk6 Hras Nras Sos1 Pcsk5 Shc1 Grb2 TRANS-GOLGI NETWORK VESICLE BUDDING%REACTOME DATABASE ID RELEASE 66%10145468 trans-Golgi Network Vesicle Budding Ftl1 LOC100909548 Igf2r Necap1 Clvs1 Picalm Chmp2a Tgoln2 Hip1r Tfrc App Vamp2 Dnm2 Ap1m2 Gbf1 Snx5 Snx9 Snx2 Acbd3 Sort1 Cpd Dnase2 Clint1 Yipf6 Ap4s1 Ap1b1 Vamp8 Tpd52 Sh3gl2 Stx4 Ocrl Ap4e1 Golgb1 Ap4b1 Ap1g2 RGD1561661 Ctsz Napa Tpd52l1 Cltc Cltb Snapin Ap1m1 Clta Ap3b1 LOC100360087 Bloc1s3 Pum1 Txndc5 Ap4m1 Bloc1s4 Bloc1s1 Bloc1s6 Rab5c Arrb1 M6pr Ap1s3 Ap1s1 Ap1s2 Pik3c2a Gak Vamp7 LIGAND-INDEPENDENT CASPASE ACTIVATION VIA DCC%REACTOME DATABASE ID RELEASE 66%10145489 Ligand-independent caspase activation via DCC Appl1 Casp3 Dcc Casp9 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145699 Ionotropic activity of kainate receptors Grik1 Dlg1 Grik3 Grik2 Ncald Grik5 Dlg3 Dlg4 SMAC-MEDIATED DISSOCIATION OF IAP:CASPASE COMPLEXES%REACTOME%R-RNO-111464.1 SMAC-mediated dissociation of IAP:caspase complexes Diablo LOC100360940 Xiap MITOTIC G1-G1 S PHASES%REACTOME DATABASE ID RELEASE 66%10144725 Mitotic G1-G1 S phases Psmc6 Psmb10 Psmb8 Pole2 Psmb9 Pole4 Psmb4 Psmb5 Psmf1 Psmb6 Psmd4 Mnat1 Psmb2 Psmd5 Psmd8 Psmd9 Psmb3 Psmd11 Psmd12 Prim2 Ccna2 Ccne2 Pola2 Ccna1 Psmd13 Prim1 Ccne1 Psmd14 Mcm2 Mcm4 Mcm3 LOC100909750 Cdk2 Mcm5 Rpa3 Mcm6 Pole Mcm10 Psmc3 Ccnh Mcm8 Mcm7 Orc4 Orc5 Orc6 Orc1 Orc2 Orc3 Cdc7 Cdc6 Cdc45 Src Rbl1 Cdk4 Akt1 E2f4 Hdac1 Rpa1 Ppp2cb Ccnd1 Ppp2ca Rpa2 Skp1 Ppp2r1a Tfdp1 Tfdp2 Skp2 Cdkn1a Cdkn1b Ppp2r1b Akt3 Lyn Ppp2r3b Cul1 Ptk6 Rbl2 Cks1l E2f5 Hdac1l Cables1 Dyrk1a Cdkn2b Cdkn2c Cdk6 Cks1b Abl1 Akt2 Gmnn Ccnd3 G6pc Rb1 E2f2 Psmb7 Psmb1 Lin37 Lin52 Lin54 E2f1 Psma5 E2f3 Cdk7 Cdt1 Lin9 Psma2 Psmc5 Psma1 Psmd2 Psma4 Psmc1 Cdc25a Psma3 Wee1 Psmc4 Psma6 Psmc2 Ppp2r2a Psme1 Psmd1 Psme2 Psmd7 Psmd3 Psmd6 HEME DEGRADATION%REACTOME%R-RNO-189483.1 Heme degradation Hmox1 Ugt1a8 Ugt1a9 Ugt1a6 Blvrb Blvra Ugt1a7c Ugt1a5 Ugt1a3 Ugt1a2 Hmox2 Ugt1a1 BIOSYNTHESIS OF DPAN-3-DERIVED MARESINS%REACTOME%R-RNO-9026290.1 Biosynthesis of DPAn-3-derived maresins Alox12 Alox5 TP53 REGULATES TRANSCRIPTION OF ADDITIONAL CELL CYCLE GENES WHOSE EXACT ROLE IN THE P53 PATHWAY REMAIN UNCERTAIN%REACTOME%R-RNO-6804115.1 TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain Btg2 Cdc25c Cnot6l Cnot11 Tnks1bp1 Cnot8 Rqcd1 Cnot3 Cenpj Cnot1 Cnot2 Plk2 Cnot7 Plk3 Cnot4 FGFR3 LIGAND BINDING AND ACTIVATION%REACTOME%R-RNO-190239.1 FGFR3 ligand binding and activation Fgf23 Fgf4 Fgf1 Fgf16 Fgf17 Fgf5 Fgf9 Fgf2 Fgf8 Fgfr3 Fgf20 Galnt3 MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 66%10145043 Muscle contraction Stim1 Tnni1 Dmpk Sri Tnnt3 Tnni2 Tnnt2 Tnni3 Tnnt1 Tmod2 Kcnd3 LOC100911951 Kcnd1 Kcnip3 Kcnip4 Kcnip2 Akap9 Tnnc2 Actn3 Kcnk16 Slc8a3 Mybpc3 Des Tmod4 Tmod3 Vim Tmod1 Ahcyl1 Tpm4 Tpm2 Myl3 Myl4 Mybpc2 Tpm3 Tnnc1 Myl12a Slc8a2 Myh6 Slc8a1 Dmd Myl1 Pxn Cacna1c Cacng7 Cacna1d Cacng1 Kcne1 Kcne2 Kcnk5 Cacng5 Kcnk6 Kcnk7 Kcne4 Scn2a Scn7a Scn4b Scn2b Fgf11 Scn9a Fgf12 Fgf13 Scn10a Scn4a Nos1 Tln1 Scn5a Fgf14 Scn3a Scn11a Rangrf Scn1b Prkaca Kcne3 Cacnb4 Cacng8 Cacnb1 Itpr1 Cacnb2 Kcnq1 Cacna2d3 Itpr3 Cacna1f Kcne5 Cacng2 Cacna1s Cacng3 Cacna2d2 Cacng4 Cacna2d4 Camk2g Atp2b4 Myh11 Vcl Kcnh2 Atp2b2 Atp2b1 Camk2d Actn2 Camk2a Clic2 Trdn Atp2a2 Pln Atp2a3 Kcnj2 Kcnj11 Kcnj14 Pak2 Pak1 Kcnk1 Kcnk12 Kcnk13 Kcnk2 Kcnk3 Npr2 LOC100909725 Npr1 Kcnk4 Kcnj12 Kcnk10 Nppc Nppa Kcnk9 Kcnk15 Corin Abcc9 Fxyd2 Kcnj4 Fxyd3 Fxyd4 LOC102551071 Sln Mylk Fxyd6 Fxyd7 Dysf Atp1b3 Myl10 Atp1b2 Atp1b1 Cav3 Fkbp1b Myl7 Actg2 Sorbs3 Cald1 Ryr2 Trim72 Sorbs1 Mylpf Kcnk18 Atp1a4 Atp1a1 Atp1a2 Atp1a3 DEATH RECEPTOR SIGNALLING%REACTOME DATABASE ID RELEASE 66%10144808 Death Receptor Signalling Faslg Nsmaf Cflar Fadd Adam17 Aph1b Psenen Aph1a Ngfr LOC100911293 Psen2 Psen1 Ncstn Rac1 Casp3 Tnf Tradd Tnfsf10 Fas Rnf31 Sharpin Traf1 Rbck1 Sqstm1 Prkci Ngf Tax1bp1 Sppl2a Clip3 Otulin Xiap Ywhae Bad Nfkb1 Bag4 Mapk8 Smpd2 Smpd3 Chuk Traf2 Usp4 Tab2 Tab3 Ikbkb Myd88 Ripk2 Usp21 Otud7b Madd Traf6 Tab1 Ripk1 Rela Map3k7 Tnfaip3 Nfkbia LOC100910771 Itgb3bp Arhgef6 Arhgef5 Arhgef39 Arhgef7 Arhgef37 Birc3 Arhgef38 Birc2 Arhgef33 Cyld Prex1 Itsn1 Arhgef2 LOC102556447 Arhgef4 Arhgef3 Plekhg5 Arhgef19 Arhgef18 Plekhg2 Kalrn Bcl2l11 LOC100912512 Vav2 Gna13 Casp2 Vav1 Arhgef11 Akap13 Casp8 Arhgef16 Arhgef15 Net1 Ect2 Arhgef26 Usp2 Fgd2 Mcf2l Tiam1 Tiam2 Vav3 Fgd3 Sos2 Ngef Rhoa Arhgdia Rtn4 Lingo1 Omg Sos1 Mag Ngfrap1 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR)%REACTOME DATABASE ID RELEASE 66%10145798 Downstream signaling events of B Cell Receptor (BCR) Psmc6 Psmb10 Psmb8 Psmb9 Psmb4 Psmb11 Nfkbib Psmb5 Psmf1 Psmb6 Psmd4 Psmb2 Cul1 Psmd5 Psmd8 Psmd9 Psmb3 Psma8 Psmd11 Psmd12 Psmd13 Rela Psmd14 Psmc3 Nfkbia Kras G6pc Psmb7 Psmb1 Skp1 Prkcb Ppp3r1 Nfkbie Nfkb1 Psma5 Fbxw11 Rasgrp1 Chuk Rasgrp3 Btrc Psma2 RGD1560225 Psmc5 Ppp3ca Psmd2 Psma1 Nfatc2 Psma4 Psmc1 Psma3 Psmc4 Psmc2 Psma6 Psme1 Hras Psmd1 Psme2 Nras Psmd7 Ikbkb Nfatc3 Psmd3 Psmd6 TNFR1-INDUCED PROAPOPTOTIC SIGNALING%REACTOME DATABASE ID RELEASE 66%10144945 TNFR1-induced proapoptotic signaling Traf2 Usp2 Fadd Usp21 Usp4 Otud7b Cyld Ripk1 Tnf Tradd Tnfaip3 KSRP (KHSRP) BINDS AND DESTABILIZES MRNA%REACTOME DATABASE ID RELEASE 66%10145696 KSRP (KHSRP) binds and destabilizes mRNA Exosc9 Exosc2 Exosc1 Exosc4 Exosc7 Exosc5 Dcp2 Ywhaz Exosc3 Khsrp Akt1 BIOSYNTHESIS OF PROTECTINS%REACTOME%R-RNO-9018681.1 Biosynthesis of protectins Cyp1a1 Cyp1a2 Alox15 Lta4h SIGNALING BY ERYTHROPOIETIN%REACTOME DATABASE ID RELEASE 66%10146295 Signaling by Erythropoietin Gab1 Pik3r5 Irs2 Pik3r1 Pik3cb Lyn Epor Crkl Pik3cd Vav1 Pik3cg Rapgef1 Shc1 Epo LOC100911248 Grb2 DISINHIBITION OF SNARE FORMATION%REACTOME DATABASE ID RELEASE 66%10145035 Disinhibition of SNARE formation Stxbp3 Stx4 Prkca Prkcb CATECHOLAMINE BIOSYNTHESIS%REACTOME%R-RNO-209905.1 Catecholamine biosynthesis Pnmt Ddc Dbh Th TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES%REACTOME%R-RNO-425393.1 Transport of inorganic cations anions and amino acids oligopeptides Slc7a3 Slc7a2 Slc7a1 Slc6a12 Slc4a7 Slc4a9 Slc7a8 Slc7a9 Sri Slc7a5 Slc7a6 Slc7a7 Slc7a10 Slc4a4 Slc4a3 Slc4a8 Slc6a6 Slc12a4 Slc12a2 Slc12a1 Slc8b1 Slc38a3 Slc38a2 Slc38a5 Slc38a4 Slc8a3 Slc12a5 Slc3a1 Slc25a29 Slc43a2 Slc43a1 Slc12a6 Slc12a7 Slc25a10 Slc8a2 Slc8a1 Slc16a10 Slc1a3 Slc9a4 Slc1a5 Slc9a5 Slc1a4 Slc15a1 Slc1a7 Slc26a7 Slc1a6 Slc26a9 Slc26a6 Slc1a1 Slc26a3 Slc36a2 Slc9a1 Slc34a1 Slc34a3 Slc32a1 Slc38a1 Slc6a15 Slc6a14 Slc6a19 Slc6a18 Ctns Slc36a4 Slc6a20 Slc36a1 Slc24a4 Slc24a2 Slc20a2 Ahcyl2 Slc5a8 Slc25a22 Slc17a5 Slc17a6 Slc4a2 Slc17a7 Slc4a5 Slc17a8 Slc4a1 LOC100911440 Slc25a18 Slc7a11 Slc5a5 Slc24a5 Slc26a2 Slc26a1 Slc9a2 Slc9a9 Slc9a3 Slc9a6 Slc20a1 Slc4a10 Slc9a8 Slc15a3 Slc9a7 SIGNAL ATTENUATION%REACTOME%R-RNO-74749.1 Signal attenuation Grb10 Insr Ins1 Irs2 Ins2 Irs1 Sos1 Shc1 Mapk1 Grb2 NONHOMOLOGOUS END-JOINING (NHEJ)%REACTOME%R-RNO-5693571.1 Nonhomologous End-Joining (NHEJ) Bard1 Bre Rad50 Brcc3 Xrcc6 Xrcc5 Pias4 Uimc1 Atm Hist1h2bo Hist1h2bcl1 Hist1h2bk Sumo1 Brca1 Mdc1 Ube2v2 Ube2n Nbn Mre11a LOC100910200 Whsc1 H2afx Hist1h4b Rnf8 Hist1h2bh LOC100912290 Babam1 Tp53bp1 LOC686349 Hist1h4m LOC100912338 Herc2 Xrcc4 Hist2h4 Hist1h2bq LOC100364835 Fam175a Tdp2 Lig4 Paxip1 Polm Hist1h2bg Nhej1 Prkdc LOC680097 Dclre1c Poll LOC684797 LOC100912418 Hist1h2ba Hist3h2bb BASIGIN INTERACTIONS%REACTOME%R-RNO-210991.1 Basigin interactions Atp1b3 Atp1b2 Atp1b1 Bsg Slc7a8 Slc7a9 Itga3 Mmp1 Slc7a5 Slc7a6 Slc7a11 Slc7a7 L1cam LOC288521 Ppil2 Slc7a10 Spn LOC100361537 Itga6 Slc16a3 Slc16a8 Mag Slc16a1 SUMO IS CONJUGATED TO E1 (UBA2:SAE1)%REACTOME DATABASE ID RELEASE 66%10145983 SUMO is conjugated to E1 (UBA2:SAE1) Sumo1 Sae1 Uba2 NUCLEAR SIGNALING BY ERBB4%REACTOME%R-RNO-1251985.1 Nuclear signaling by ERBB4 Stat5a Esr1 Src Yap1 Aph1b Psenen Aph1a Erbb4 LOC100911293 Psen2 Psen1 Ncstn LIPOPROTEIN METABOLISM%REACTOME DATABASE ID RELEASE 66%10145205 Lipoprotein metabolism Ldlr Angptl4 LOC100361444 Lmf1 Lmf2 Furin Ap2a2 Abca1 Zdhhc8 Lcat Lipg Pltp Bmp1 Sar1b Apob Apoc2 Apoe Apoa2 Mttp Nr1h3 Nr1h2 Gpihbp1 Cltc Scarb1 Cubn Clta Amn Hdlbp Apoa1 Ap2s1 Ap2a1 Ap2m1 Pcsk9 P4hb A2m Apobr Vldlr Npc1 Nceh1 Lipa Mylip Soat1 Soat2 Prkaca Prkacb Lpl Apoc1 LOC100910181 Abcg1 Pcsk6 Apoc4 Ldlrap1 Pcsk5 CA ACTIVATED K+ CHANNELS%REACTOME DATABASE ID RELEASE 66%10145832 Ca activated K+ channels Kcnn4 Kcnn1 Kcnma1 Kcnmb4 Kcnmb3 Kcnn2 Kcnn3 Kcnmb2 Kcnmb1 SYNTHESIS OF IPS IN THE ER LUMEN%REACTOME%R-RNO-1855231.1 Synthesis of IPs in the ER lumen Minpp1 LEUKOTRIENE RECEPTORS%REACTOME%R-RNO-391906.1 Leukotriene receptors Gpr17 Ltb4r Cysltr2 Cysltr1 Ltb4r2 CELL JUNCTION ORGANIZATION%REACTOME%R-RNO-446728.1 Cell junction organization Pvrl3 Crb3 PVR Pvrl4 Pvrl1 Rsu1 Cdh10 Cdh11 Cdh17 LOC100911730 Cdh13 Cdh7 Cdh9 Fermt2 Flnc Inadl Cdh24 Pard6b Cd151 Lamc2 Itgb4 Cadm3 Itga6 Cadm2 Mpp5 Ang2 Flna Pvrl2 Plec Cdh15 Actn1 Lamb3 Parvb Lims1 Arhgef6 Ilk Pard6a Dst F11r Jup Prkci Fblim1 Vasp Pard3 Cdh1 Cdh2 Ctnna1 Sdk2 Ctnnd1 Cdh3 Pard6g Cdh5 Cdh6 Col17a1 PHOSPHORYLATION OF THE APC C%REACTOME DATABASE ID RELEASE 66%10145220 Phosphorylation of the APC C Anapc7 Cdc26 Cdc27 Cdc23 Ube2c Ube2d1 Cdk1 Anapc16 Cdc16 Anapc4 Anapc2 Anapc1 Anapc11 Anapc15 Anapc10 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY%REACTOME DATABASE ID RELEASE 66%10145655 Zinc influx into cells by the SLC39 gene family Slc39a2 Slc39a3 Slc39a4 Slc39a14 Slc39a6 Slc39a7 Slc39a8 P75 NTR RECEPTOR-MEDIATED SIGNALLING%REACTOME%R-RNO-193704.1 p75 NTR receptor-mediated signalling Ripk2 Adam17 Aph1b Psenen Aph1a Ngfr LOC100911293 Psen2 Psen1 Rac1 Traf6 Ncstn Casp3 Rela Sqstm1 Nfkbia Itgb3bp Arhgef6 Arhgef5 Arhgef39 Arhgef7 Arhgef37 Arhgef38 Arhgef33 Prex1 Itsn1 Arhgef2 LOC102556447 Arhgef4 Arhgef3 Plekhg5 Prkci Arhgef19 Arhgef18 Plekhg2 Ngf Kalrn Bcl2l11 LOC100912512 Vav2 Gna13 Casp2 Vav1 Arhgef11 Akap13 Ywhae Arhgef16 Arhgef15 Bad Net1 Nfkb1 Ect2 Arhgef26 Mapk8 Fgd2 Mcf2l Tiam1 Tiam2 Vav3 Fgd3 Sos2 Ngef Rhoa Arhgdia Rtn4 Lingo1 Omg Ikbkb Mag Sos1 Myd88 Ngfrap1 METABOLISM%REACTOME DATABASE ID RELEASE 66%10144767 Metabolism Smarcd3 Enoph1 Mtap Mri1 Adi1 Abcd1 Acot6 Acot4 Acot8 Acox1 Ehhadh Eci3 Hsd17b4 Mlycd Ecsit Mapkapk2 Fabp2 Gpam Mogat1 Fabp9 Lpin2 Mogat2 Lpin3 Lpin1 RGD1562200 Dgat2 Gk2 Plin3 Gpat2 Gpd2 Agmo Gpihbp1 Arsi Smpd1 Arse Cptp Arsg Smpd2 Esyt3 Smpd3 Arsk Sts Esyt2 Smpd4 Gba2 Sumf2 Sumf1 B3galnt1 Ugt8 Ugcg Med1 Fabp3 Fabp6 Fabp1 Fabp4 Gk Fabp12 Pnpla5 Fabp7 Mgll Carm1 Ptges3 Ptges3l1 Crebbp Folr2 Ncoa1 Pik3r1 Pik3r2 Adra2a Gnai2 Adra2c Pik3cb Gnai1 Oca2 Slc45a2 Tyrp1 Tyr LOC308670 Bsg Fah Tat Pnlip LOC103690254 Try10 LOC100365995 Pcbd1 Aanat Hpd Asmt Phykpl Tph1 Slc2a2 Tph2 Hgd Clps Il4i1 Pah Asrgl1 Qdpr Ipmk Ip6k2 Blvrb Blvra Minpp1 Prkca Pnmt Ddc Dbh Th Try4 Prss2 Prss1 Rimklb Gpt Aspa Nat8l Naalad2 Folh1 Pycrl Aldh18a1 Oat Asns Pycr2 Pycr1 Prkg2 LOC102554637 Ndufab1 Ppapdc2 Pten Ptgds Pla2g6 Pla2g3 LOC683884 Pla2g5 Pitpnb Helz2 Sc5d Pla2g16 Dpep3 Pla2g15 Dpep1 Pla2g10 LOC103689982 Lhb Nsdhl Osbpl5 Osbpl8 Osbpl3 Osbpl6 Osbpl9 Fam73b Osbpl7 Cyp19a1 Fdx1l Ppap2a Por LOC100360055 Sacm1l Aoc3 Ppap2b LOC683849 Slc22a5 Ces2c Awat1 Awat2 Msmo1 Agps Cpt1b Alpp Alpi Cpt1a Acat2 Acat1 Fig4 Ttr LOC100911154 Cpne6 Acp6 LOC100910957 Cpne7 Mcat Cers4 LOC100910122 Cers3 Mvd Agk Acot11 Slc25a17 Cers6 Cyp4f17 Tmem86b Lclat1 Acot13 RGD1564865 Slc25a20 Cga Cyp4f18 Pik3r5 Bmx Aacs Etnppl Tbxas1 Cept1 Pik3r3 Pik3r6 Cers1 Acer2 Acer1 Acer3 Pi4kb Cyp51 Mut Cers2 Inpp5d Inpp5e Ppt1 Ppt2 Ncoa6 Gdf1 Slc21a4 Inpp5f Bzrap1 Tnfaip8l3 Dgat2l6 Tnfaip8l1 Abcb11 Inpp5j Tnfaip8 Tnfaip8l2 Stard3nl Vapb Rufy1 Ormdl1 Acox3 Ptdss2 Acox2 Srd5a3 Cdipt Aldh3a2 Sin3a Sin3b Cyp4f6 Ormdl2 LOC317456 Ppap2c Osbpl10 Cbr1 Tspo Crls1 LOC100912391 Cpt2 Cyp24a1 Mcee Srd5a1 Srd5a2 Pmvk Srebf1 Pik3c2a Pik3c2b Srebf2 Pik3c2g Cds2 Hmgcll1 Cyp4a2 Adprm Pla2r1 Nudt9 Sqle Nudt5 Cyp4a1 Nudt16 Ptgis Nudt18 Tpte2 LOC688828 Pla2g4e Pla2g4b Lgmn Pla2g4d Inpp4a Pdss2 Aloxe3 Cyp4a8 Coq2 Inpp4b LOC100912469 Pctp Pla2g4a Cds1 Cbr4 Acot7 Acot9 Pla2g4c Acot2 Cyp2j10 Acot5 Fdft1 Acss3 Kcnj11 Abcc8 Nudt15 Nudt1 Cyp2b2 Cyp2c24 Cyp2s1 Cyp2b1 Marc2 Marc1 Aip Cyp2b3 Ephx1 Nqo2 Cyp26c1 Aldh3a1 LOC100910040 Bphl Ahrr LOC100361492 Ahr Maob LOC100910127 Ces1d Cyp2c13 LOC100910481 Aadac Cmbl Ces2 Slc5a8 Ces2j Cyp2b21 Arnt Ces2e Ces2g Acss1 Cbr3 Ces2h LOC100911763 Slc5a5 Cyp2b15 Fmo1 Cyp2b12 Adh4 Fmo2 Cyp2f4 Cyp26a1 Adh6 Arnt2 Adh7 Cyb5b Cyp4v3 Aldh1b1 Cyp26b1 LOC100365112 Nr1h4 Bpnt1 Abhd14b Enpp6 Nat1 Cyp1b1 Nat2 Mbtps1 Cidec Sult6b1 Tecr Podxl2 Sult4a1 Mbtps2 Sgpl1 Sult2a1 Echs1 Nudt7 Sbf1 Ptpn13 Nat3 Hdac3 Slc7a5 LOC100365676 Hsd17b3 Hsd17b8 Csnk2a2 Acsbg1 Hsd17b1 Hsd17b2 Pla2g12a Far2 Far1 Csnk2a1 Stard7 Slc6a7 Stard6 Slc46a1 Acoxl Stard3 Fa2h RGD1562948 Gc Acsbg2 Alox5ap Sptssb Lpcat4 Sptssa Eci1 Stard4 Stard5 Plbd1 Abhd4 Akr1c12l1 Lipi Mid1ip1 Baat Cyp46a1 Lpcat3 Slc22a3 Lpcat2 Fitm1 Acy3 Fitm2 LOC100910526 Hpgds RGD1562392 Akr7a2 Gnpat Akr1c19 ste2 Impad1 Vac14 Tpst1 Abhd3 Thrsp Tpst2 Tbl1x Sult2b1 NEWGENE_1306455 Hsd3b Akr1c13 LOC100910057 Akr1c14 Sult1b1 LOC100910881 LOC681458 Sult1a1 Akr1c12 Sult1c2 Pla2g4cl1 Acy1 Fasn Chat Xylb Ncan Csnk1g2 Hexb Amacr Hexa Akr1d1 Chst7 Cyp4f39 Chst9 Cyp39a1 Pomc Ugp2 Pld2 Vdr Pld6 Tecrl Synj1 Scap Fdx1 Sds Plekha4 Plekha3 Hrsp12 Slc9a1 Plekha5 Chst5 Pon3 Sdsl Pon1 LOC102550316 Chst3 Pon2 Nup88 Plekha8 Chst2 Degs2 Chst1 Synj2 B3gnt4 Plekha1 Hsd3b1 B3gnt7 Alppl2 B3gnt1 Hsd3b2 B3gnt2 Pik3cd B3gnt3 Pik3cg Nup85 Hsd3b7 Pgk2 G6pc3 Acadvl Acsl3 Pgk1 Acsl1 Gpc6 Acsl6 Rbks Acsl5 Slc37a2 Acsl4 Pkm Taldo1 Agpat1 Slc35d1 Chpf2 Agpat4 Agpat3 Gpc4 Ch25h Gpc2 RGD1564347 Ndst1 Pnpla8 Pgam1 Agpat9 Pgam2 Acaa2 Ndst2 Cyp2u1 Rae1 Cryl1 Agpat6 Agpat5 Ndst3 Etnk1 Ndst4 Adpgk Pnpla3 Ogn Alox15b Pnpla2 Glb1 Pnpla6 Pck1 St3gal2 Samd8 St3gal3 Acbd7 Acad10 Slc26a2 Acad11 Slc26a1 St3gal1 Ptgs1 Bpgm Acbd5 Gpc1 Hacl1 Nhlrc1 Acbd6 Slc37a1 Dhcr24 Mmaa St3gal4 St3gal6 Acbd4 Pi4k2b B3galt6 Slco1a1 Nup93 Ddhd2 Slc35b2 Epm2a Ddhd1 Arv1 Kera Slc44a4 Nup98 Phyh LOC100911625 Nup107 Slco1a4 Slco1a2 Slc35b3 Eno3 Slc44a5 Mboat1 Glyctk RGD1306195 Gapdhs Manba Slc44a3 Eno1 Hmgcl Slco1b2 Tkfc Mboat7 Eno2 LOC688708 Nup210 Akr1b7 Aldoa Akr1b8 Prelp Kdsr LOC100911750 Mtmr14 Gyg1 LOC102556347 Aldob Ppara Aldoc Mtmr12 Cspg5 Taz Cspg4 Iscu Nupl2 Ppard Star Pgls Isca2 Gckr Acadl Isca1 Hmgcs2 Nupl1 Pklr Acads Acan Cyp7b1 Lyrm4 Pc Acadm Glrx5 Dsel Sgpp2 Tyms Pip5k1c Tkt Bcan Dtymk Hrasls5 Pi4k2a LOC305806 Pfkfb3 Nme3 Pfkfb4 Pip5k1b Nmral1 Nudt13 Pfkfb1 Pip5k1a Hmgcs1 Ass1 Nme1 Pfkfb2 Chsy1 Akr1c2 Ak5 Nags Cps1 Khk Scd4 Ak4 Hao2 Ak6 Slc25a2 Pfkl Akr1c3 Ak8 Pgm2 Prps2 Rrm2b Cyp7a1 Tm7sf2 Pgm1 Dut Cyp21a1 LOC100910284 Ctps2 Fdxr Ctps1 Pfkp Pcyt1b B4galt1 Pcyt1a Ext1 Tgs1 Ext2 LOC100911186 B4galt3 Them5 B4galt2 Acsf2 B4galt6 Cyp2r1 B4galt7 Scd1 B4galt4 Scd2 B4galt5 Acsf3 Hs3st3b1 Glrx Pitpnm1 Nup205 Aldoart2 Dbi Rrm2 Pitpnm3 Naglu Rrm1 Slc25a11 Pitpnm2 Lalba Morc2 Dctd Slc25a10 LOC100360124 Ocrl Akr1c1 Phka1 LOC100359853 LOC100911941 Guk1 Cemip Shpk Stard10 Osbp Agrn Stab2 Fads1 Hk2 Pcyt2 Xylt2 Mtmr9 Mtmr6 Pgm2l1 Mtmr7 G6pc Mtmr2 Agl Serinc4 Chst12 Ggps1 Nup155 Psph Dpep2 Serinc2 Chst11 Ptges Serinc3 Lum Tbl1xr1 Srr Dcn Faah Serinc1 Tpi1 Pla2g2a Pla2g2f Csgalnact1 Pla2g2d Csgalnact2 Hs6st2 Gmpr2 Gpd1l Ampd1 Chst13 Pla2g1b LOC686302 Gmpr Prps1l1 Elovl1 Gys1 Gpi LOC100911615 Elovl5 Gys2 Elovl2 Slc25a1 Rpia Elovl3 Xdh Papss2 Crot Slc27a5 Papss1 Hs6st1 Chka Mtmr3 Idua Dguok Ust Mfsd2a Mtmr1 Hprt1 Chst15 Slc36a4 Elovl6 Chst14 Ada Ampd2 Nup153 Cyp11b2 Rpe Sgms1 Mthfs Cyp27b1 Mthfd1l Vcan Phkg1 Morc2b Mthfd2l Decr1 Gale Dhfr Slco1a6 Hs3st3a1 Omd Hacd1 Dse Phospho1 Tpr Dhcr7 Mthfr Mthfd2 Glb1l Bdh2 Hadh Galk1 Mthfd1 Akr1b1 Shmt1 Sphk2 Aldh1l2 Arsb Lpgat1 Hadha LOC100910891 Aldh1l1 Slc19a1 Phkg2 Col4a3bp Man2c1 Slc25a32 Hadhb Gnpda2 Shmt2 Cyp8b1 Dera Gpd1 Akr1a1 Hsd17b14 Slc35d2 Slc10a1 Hmgcr Nup54 Psat1 Gusb Ebp Pemt Phgdh Hpse Man2b1 Crat Slc2a1 Pccb Pom121 Hacd4 Hs3st5 Hacd3 Chpf Pikfyve Hsd11b2 Nup62 Hs3st2 Hsd17b13 Hs3st1 Slc10a2 Dcxr Hsd17b12 Hs3st6 Hsd17b11 Cd44 Phkb Lyve1 Nup43 Nup133 Mdh2 Gaa Mdh1 Has1 Aaas Pygl Has2 Pygm B3gat1 B3gat3 B3gat2 Npap60 Got1 Fbp1 Nup35 Fbp2 Hyal1 Nup37 Hyal2 Chp1 Sdc2 Sdc3 Sdc4 Sord Fmod Galt Got2 Hs2st1 Ranbp2 Ppp1r3c Car6 Car13 Car12 Car3 Car7 Car9 Car5a Car14 Car5b Cpox Fech LOC687381 Ppox Hmbs Cox10 Alas2 LOC100911779 Cox15 Urod Uros Ckb Sms LOC100912604 Ckmt1b Amd1 Gamt LOC100364487 Srm Amdhd1 Carns1 Hnmt Hal Hdc Ftcd Uroc1 Glul Aox1 Pnpo Bckdk Bcat1 Hsd17b10 Bcat2 Sptlc3 Hibadh Sptlc1 Auh Prkd3 Aldh6a1 Sptlc2 Ivd Prkd1 Acadsb Hibch Prkd2 Tmlhe Ppm1k Oxct1 Ugdh Cad Ppa2 Prodh Nt5c1b Scly Gda Itpa Samhd1 Umps Dnph1 Dhodh Plcb1 Plcb3 Ffar1 Gnaq Gna11 Gna14 Gna15 Plcd3 Plcz1 Plcd1 Plcd4 Inpp5b Itpka Plce1 Pld4 Plch1 Plch2 Plcb4 Maoa Slc22a1 Slc22a2 Aldh2 Itpkb Comt Itpkc Bche Nt5c1a Nt5c Nt5c3a Nt5e Ache Upb1 Nt5m Akt1 Dpys Agmat Ucp2 Ucp3 LOC100909612 Slc25a14 Ucp1 Pdxk Ctsa Pnp LOC100909857 LOC498300 Arg1 Psmb7 Psmb1 Vapa Nme2 Psma5 Rap1a Psma2 Psmd2 Idh1 Bst1 Psmc2 Psmd1 Psmd7 Psmd3 Psmd6 Slc6a11 Slc6a12 Tpo Iyd Duox2 Duox1 Tshb Nudt11 LOC100912928 Nudt3 Ppip5k1 Ppip5k2 Nudt10 Ip6k1 Ippk Nudt4 Itpk1 Rxra Mpst Txn2 Suox Cbs Sqrdl Bhmt2 Ethe1 Cdo1 Cth Tstd1 Tst Sar1a Lrp1 Plcg1 Cacna1e Glyatl3 Acsm1 Slc25a5 Adipor1 Glyat Adipor2 Marcks Adipoq Mmadhc Abcd4 Cd320 Mmab Tcn2 Mmachc Ctrc Lmbrd1 Lpcat1 Acacb Slc5a6 Mccc2 Pdzd11 Hlcs Mccc1 Gcsh LOC100911156 Ndufaf7 Ndufa7 Ndufaf5 Rfk LOC100911034 Pts Apoa1bp Tpk1 Rnls Carkd Slc52a2 Slc52a3 Slc23a2 Gch1 Nampt Mocs1 Ldha Cd38 Ndufb6 Ndufb3 Enpp1 Parp14 LOC100912599 Ndufb5 LOC100910173 Vdac1 Nudt12 Nmnat2 Ldhb Nmnat1 LOC100361505 Acp5 Me2 Hagh Mocos Fahd1 Nmrk1 Nmrk2 Me3 Nfs1 Ndufb9 Nadsyn1 Ndufb4 Ndufb8 Cyb5a Gchfr Ndufb7 Flad1 Sdhc Parp9 Sdhd Mocs3 Ndufaf3 Parp6 Sdha RGD1563242 Me1 Atp5j2 Thtpa Parp8 Dlst Qprt Ndufaf1 Ndufa2 Ndufa5 Ndufaf4 Ndufa6 Slc19a2 Mt-atp8 Sdhb Nadk RGD1306782 Slc25a19 Ndufa1 Ndufs3 LOC500350 Ndufs1 Ogdh Ndufs4 Atp5g3 Ndufs5 Ndufs2 Ndufs8 Coq10a Ndufs6 Ndufs7 Pdpr Timmdc1 Pdhb Atp5g2 Pdk3 Pdk4 Pdk1 Pdk2 LOC100365902 LOC684509 Pdha2 Pdha1 Pdhx Pdha1l1 Acad9 Suclg2 Ndufb2 Ldhc Nnt LOC679739 LOC100911417 Idh3a Etfdh Gstz1 LOC679195 D2hgdh Pdp1 LOC100910710 Aco2 LOC680288 Adhfe1 Idh3B LOC688963 Dlat L2hgdh Atp5l Atp5o Atp5h Tmem126b Atp5i Atp5j LOC100363268 Ndufv3 LOC100361144 Ndufv1 Ndufv2 Atp5s Atp5e Atp5d Fh Atp5b Dld Mt-nd4 Atp5f1 Cda Ndufa7l Mt-nd5 Psap Sardh Etfa Dmgdh Etfb Svs1 Chdh Idh3g Mt-nd6 Entpd2 Nubpl Mt-nd2 Glo1 Idh2 Entpd6 LOC100911483 Entpd3 Cs Entpd4 Ndufb10 Acly Entpd1 Ndufb11 Entpd7 Ndufa12 Ndufa11 Doxl2 Entpd5 Doxl1 Mt-atp6 Entpd8 Cpne3 Ndufa13 Ndufa10 Psmd11 Sucla2 Psmd12 Fabp5 Psmd13 Psmd14 Aldh3b1 Ndufc2 Aprt Cpne1 Psmc3 RGD1564463 Mgst1 Ugt2b Ugt1a8 Ugt2b37 Ugt1a9 Ugt1a6 Ugt2b35 Ugt2a1 Ugt2b15 Hsp90ab1 Ugt1a1 Ugt2b17 RGD1559459 Ptges2 Alox5 Ugt1a7c Ugt1a5 Ugt1a3 Ugt1a2 Neu1 Lta4h Ampd3 Slc27a2 Dgat1 Naprt1 Gm2a Inpp1 Kpnb1 Inpp5a Isyna1 Pld1 Impa1 Impa2 LOC100910990 Vnn1 Kmo Kynu Ccbl1 Ido1 Arsa Tdo2 Lipt2 Lipt1 Agxt2 Acaa1a Bckdhb Acaa1b Amt Grhpr Hao1 Hoga1 Gnmt Tas1r2 Slc44a2 LOC103692716 Ddo Ubiad1 Dhtkd1 LOC100911564 Aldh4a1 Dbt Gldc Agxt Iffo2 Lias Rbm12 Gstp1 Hscb Asah1 Otc Hmox2 Impdh1 Impdh2 Csnk2b Alad Gla Rbp4 Lrp10 Rbp2 Tex12 Rbp1 Lrp8 Aoc1 Ttpa Apom Agpat2 Lrp12 Lpl Bco1 Rdh11 Lrat Cyb5r3 Bco2 Degs1 Nosip Nos3 Dnm2 Ddah2 Zdhhc21 Nostrin Ddah1 Spr Cygb Car2 Car1 Cacna1c Cacna1d Ncor2 Mtmr4 Gsta5 Gss Cacnb2 Cacna2d2 Nt5c2 Adal Gstm7 Ggct Esd Gclm Gstm5 Gsto2 Gstk1 Cndp2 Gclc LOC100912430 Gstt2 Ggt7 Ggt6 Chac2 Chac1 Mgst3 Oplah Pank4 Coasy Pank3 Pank2 Ppcs Apob Apoc2 Pank1 Apoe LOC100362038 Apoa2 Aasdhppt Gng10 Acss2 Ppcdc Uck1 Tymp Dck Txnrd1 Prkab2 Gsr Adcy5 Adcy6 Prkar1b Prkar1a Uckl1 Tk2 Hdhd1 Uck2 Upp1 Upp2 Tk1 Tmem55b Pip4k2b Pip4k2c Neu4 Neu2 Gltp B4galnt1 Neu3 Cerk Enpp7 Gba Galc Asah2 Txn1 Prkaa2 Prkar2b Prkar2a Smox Sat1 RGD1564480 Paox Cyp2d5 Cubn Amn Apoa1 Hpgd LOC100361547 Gpx4 Cyp3a23/3a1 Cyp3a73 Cyp2c7 Pfas Alox12 Ppat Cyp2e1 Ltc4s LOC100912917 Gstm4 Cyp2d4 Cyp3a18 Cyp1a1 LOC100910877 Adss Gmps Cyp2d2 Ptgs2 Lhpp Atic Ephx2 Cyp1a2 Gart Alox15 Adsl Adssl1 Cyp2d3 Paics Cyp2c6v1 Gcgr Pipox Aldh7a1 Gcdh Aadat Wasl Hykk Pik3c3 Ncoa2 Pik3r4 Nqo1 Psmc6 Oaz3 Psmb10 Oaz1 Oaz2 Psmb8 Psmb9 Psmb4 Psmb11 Psmb5 Psmf1 Psmb6 Psmd4 Psmb2 Psmd5 Psmd8 Psmd9 Psmb3 Azin1 Psma8 Slc16a3 Slc16a8 Slc16a1 Mat1a Mat2b LOC100363915 Ahcy N6amt1 Nnmt Mat2a As3mt Tpmt Mtrr Trmt112 Gsto1 Mtr Gnb3 Gnb5 Kcnc2 Gnb2 Gnb1 Gng13 Gng12 Gng11 Prkaca Prkacb Itpr1 Kcns3 Rapgef4 Itpr3 LOC100912034 Gnb4 Glp1r Gcg Gng4 Gngt2 Gng5 Gngt1 Gng8 Gng3 Hmox1 Them4 Psmc5 Psma1 Psma4 Psmc1 Psma3 Psmc4 Psma6 Psme1 Odc1 Psme2 XBP1(S) ACTIVATES CHAPERONE GENES%REACTOME%R-RNO-381038.1 XBP1(S) activates chaperone genes Sec63 Serp1 Sec61a1 Sec62 Sec61a2 Sec61b Asna1 LOC100363239 Sec61g LOC100361694 COPI-MEDIATED ANTEROGRADE TRANSPORT%REACTOME%R-RNO-6807878.1 COPI-mediated anterograde transport Stx5 Bet1 Dync1li2 Arf5 Copa LOC100910557 Sptan1 Dync1i2 Arf4 Gbf1 Actr10 Cog4 Cd59 Dync1h1 Cog6 Cog8 Cog3 Cog1 Cog2 Dync1li1 Cog7 LOC102555167 Copg1 Dynll2 Dctn5 Dctn6 Copz2 Ins1 Dync1i1 Copz1 Ins2 Rab1b Rab1a Ykt6 Dctn4 Tmem115 Folr1 Dctn1 Tmed7 Arfgap2 Tmed3 Ank1 Tmed2 Dctn2 Uso1 Golgb1 Arfgap3 Napg Gorasp1 Napb Copb1 Napa Dctn3 Arfgap1 Tmed9 Spta1 Nsf Capzb Kdelr1 Cope Capza2 Sptbn1 Capza3 Arcn1 Kdelr2 Actr1a Gosr2 Gosr1 LOC100363782 Tmed10 Kdelr3 INTERLEUKIN-12 SIGNALING%REACTOME DATABASE ID RELEASE 66%10145676 Interleukin-12 signaling Il12rb1 Il12rb2 P4hb Il12b Jak1 Il12a Tyk2 Vamp7 NONSENSE-MEDIATED DECAY (NMD)%REACTOME%R-RNO-927802.1 Nonsense-Mediated Decay (NMD) Rnps1 LOC100912571 Magohb Rps20 Rps27l Rbm8a LOC100360573 Eif4g1 Rps4x LOC100359951 LOC100359593 Rpl30 Rpl4 LOC100359503 Rplp0 LOC100362640 Rpl6 Rpl13a Rpl26 Rps3 LOC100363800 Rps15a LOC685963 Rpl32 Rps2 Rps13 Gspt1 Rps12 Pnrc2 Pabpc2 Pabpc6 LOC100911372 Rplp1 LOC100361854 Rpl39 LOC684988 Rpl38 LOC103689992 Gspt2 Rps5 Rpl22 Rps7 Rpl23 Rpl10l Rps6 Smg8 Upf1 Rpl15 RGD1563300 Rpl19 Rpl10a Smg9 LOC100362830 LOC690468 Rpl29 LOC100363012 Smg7 Smg6 LOC680559 Smg5 Rpl39l LOC100362149 Upf3b Rpl41 LOC100912182 LOC100360057 Upf3a Rpl36al Etf1 Rpl13 Rpl3l Rpl36a Dcp1a Rps16 Ppp2ca Ppp2r1a LOC100911431 Pabpc1 Rps18 LOC100360679 Rps15 Magoh Rps3a Ncbp2 Ncbp1 Eif4a3 Ppp2r2a REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE%REACTOME%R-RNO-3371453.1 Regulation of HSF1-mediated heat shock response Nup93 Dnajb6 Nup43 Nup98 Nup133 l7Rn6 Nup107 Aaas Nup210 Npap60 Hspa14 Hspa13 Nup35 Nup37 Dnajc7 Nupl2 Ccar2 Nupl1 Hsph1 Atm Hspa12b Hspa12a Rpa3 Atr Nup205 Ranbp2 Dnajb1 Hsf1 Hspa1l Nup155 Hspa2 Rpa1 Nup88 Rpa2 Nup85 Ywhae Nup153 Bag1 Bag2 Bag4 Bag5 Bag3 Tpr Hspa9 Hspa5 Rae1 Mapkapk2 Hspa4 Mapk1 Nup54 Pom121 Nup62 TRANSCRIPTIONAL REGULATION BY TP53%REACTOME DATABASE ID RELEASE 66%10144748 Transcriptional Regulation by TP53 Rfc2 Gtf2h1 Gtf2h2 Usp7 Mdm2 Banp Mnat1 RGD1565904 Cdk5 Csnk2a2 Polr2g Polr2h Polr2e Polr2f Polr2j Csnk2a1 Polr2k LOC685619 Polr2d Polr2i Pml Polr2b Polr2c Polr2a LOC100912534 Triap1 Ell Rpa3 Tp53bp2 Atp5c1 Tcea1 Pcna Brca1 Taf7l Blm Ccnh Mapkapk5 Pidd1 Gtf2h3 Rfc5 Rfc4 Rfc3 Gtf2h5 Gtf2h4 Ing2 Ccnt2 Tceb3 Cdk9 Akt1 Hdac1 Ercc3 Brpf3 Rpa1 Nuak1 Rpa2 Hipk2 Brpf1 Ccnk Brd1 Supt5h LOC100911822 Taf7 Taf3 Ercc2 Taf6 Kat6a Taf5 Ing5 Tp53inp1 Zfp420 LOC100911519 Tp63 Cdkn1a Cdkn1b Chm Nelfe Nelfa Nelfb Cradd Bnip3l Gadd45a Bax Slc25a16 Ssrp1 L3mbtl1 Map2k6 Dyrk2 Rabggta Tp53rk Supt16h Aurka Cdc25c Aurkb Rabggtb Cdk5r1 Prelid1 Taf11 Taf15 Ppp2r5c Gpi Taf13 Taf12 Taf4b Noc2l Supt4h1 Pou4f2 Cdk7 Hipk1 Pdpk1 Ppp1r13b LOC100910137 Ppp1r13l Ttc5 Rhno1 Bard1 Wrn Topbp1 Rbbp8 Rmi1 Rmi2 Rad50 LOC364561 Pin1 Brd7 Ccna2 Plk2 Sesn2 Ccna1 Txnrd1 Ccne2 Plk3 Rffl Sesn1 Ccng1 Ccne1 RragB Tp73 Prkab1 Phf20 Sesn3 Atm Prkab2 Rictor Gsr Atrip E2f7 Cdk2 E2f8 Btg2 Tceb2 Cnot6l Tceb1 Cnot11 Rad1 Atr Rad17 Setd8 Tmem55b Rad9a Pip4k2b Nbn Pip4k2c Rad9b Mre11a Hus1 Tnks1bp1 Cnot8 Rqcd1 Cnot3 Ppp2cb Cnot1 Ywhah Ppp2ca Ywhag Cnot2 Sfn Ppp2r1a Ywhaz Cnot7 Cnot4 Ywhab Ywhaq Ywhae Mtor Prdx1 Ddit4 Rheb Prkag3 Rptor Lamtor4 LOC502894 Tsc1 Lamtor5 Ppp2r1b Txn1 Mlst8 Prkaa1 Tsc2 Rraga Prkaa2 Rragc Akt3 Rragd Slc38a9 Mapk14 Mapk11 Prmt5 Lamtor3 Gtf2f1 Gtf2f2 Lamtor2 Lamtor1 Hdac2 Mbd3 Chd3 Hdac1l Chd4 Zfp385a Mta2 Gatad2a Tbp Akt2 Gatad2b Meaf6 LOC100909949 Smyd2 Rbbp7 Ehmt2 Ehmt1 Cdk12 Taf2 Cenpj Slmo1 Taf9 Cdk13 Casp2 Csnk2b Usp2 Tpx2 Daxx LOC100910954 Cdk1 Mdm4 Chek2 Taf10 Rnf34 Mapkap1 Sgk1 Taf9b ROBO RECEPTORS BIND AKAP5%REACTOME%R-RNO-9010642.1 ROBO receptors bind AKAP5 Robo3 Akap5 Prkca INTERLEUKIN-35 SIGNALLING%REACTOME DATABASE ID RELEASE 66%10145680 Interleukin-35 Signalling Il12rb2 Canx Stat1 Il6st Jak1 Il12a Stat3 Tyk2 Ebi3 Il27ra TRANSLATION%REACTOME%R-RNO-72766.1 Translation Mrps11 LOC100912571 Mrps12 Eif3l Mrps16 Eif2s3 Mrps14 Eif3m Mrps18b Eif3j Eif4ebp1 Mrps18c Mrps10 Eif3k Mrps18a Rps20 Mrps33 Rps27l Mrps34 Eif3e Eif3f Mrps21 Mrps35 Eif2b1 Mrps17 Eif3b Mrps15 Eif3a Mrps31 Eif3d Mrps30 Eif3c Mrps24 Mrps23 Mrps22 mrpl9 Mrps28 Mrps27 Mrps26 Mrps25 LOC100360573 Mrpl4 Eif2s1 Mrpl3 Eif2s2 Mrpl2 Eif4g1 Oxa1l Mtrf1l Rps4x LOC100359951 LOC100359593 LOC367117 Eif5 LOC100359503 LOC100362640 Rpl13a Rps3 Mrrf Rps15a Rps2 Mrpl1 Mrpl13 Gspt1 Rps13 Mrpl10 Rps12 Mrpl18 Pabpc2 Mrpl19 Pabpc6 Mrps9 LOC100911372 LOC100361854 Mrps2 LOC684988 Mrps5 LOC103689992 Gspt2 Mrps7 Rps5 Mrpl36 Rps7 Mrpl37 Mrpl20 Eif2b5 Rps6 Mrpl14 Eif2b3 Mrpl16 Eif2b4 Mrpl12 Eif3g Mrpl15 Eif3h Eif4a2 LOC100362830 Mrpl41 Eif1ax Mrpl35 Eif4a1 Mrpl40 LOC100363012 Mrpl33 LOC680559 Mrpl34 LOC100911110 Mrpl38 LOC100362149 Mrpl32 Mrpl27 N6amt1 Mrpl23 Mrpl28 Mrpl30 Mrpl21 Trmt112 Mrpl54 Mrpl46 Mrpl55 Mrpl44 Mrpl43 Etf1 Mrpl47 Mrpl49 Mrpl53 Mrpl48 Mrpl52 Mrpl51 Mrpl50 Apeh Rps16 LOC100911431 Pabpc1 Rps18 LOC100360679 Rps15 Eif4h Eif4b Rps3a Sar1a mrpl11 mrpl24 Chchd1 Dap3 Eral1 Gadd45gip1 Ict1 Eef2 Ptcd3 Ppa2 Gfm2 Gfm1 TP53 REGULATES TRANSCRIPTION OF CASPASE ACTIVATORS AND CASPASES%REACTOME%R-RNO-6803207.1 TP53 Regulates Transcription of Caspase Activators and Caspases Cradd LOC100911519 Pidd1 Casp2 Atm VISUAL PHOTOTRANSDUCTION%REACTOME%R-RNO-2187338.1 Visual phototransduction Opn1sw Dhrs3 Rlbp1 Cnga1 Gucy2f Pde6b Rcvrn Gucy2d Pde6a Rgs9 RGD1560341 Akr1b7 Akr1b8 Sdc2 Sdc3 Sdc4 Opn1mw Awat2 Stra6 Rdh10 Rdh16 Akr1c2 LOC100365958 LOC100362350 Akr1c3 Akr1c12l1 Ttr Guca1b Ppef1 Metap2 Metap1 Gnat1 Apob Akr1c19 Apoc2 Nmt1 Guca1a Apoe Cngb1 Apoa2 Rgs9bp Fnta Nmt2 Akr1c13 Sag Akr1c14 RGD1564865 Grk4 Akr1c12 Grk1 Fntb Akr1c1 Pde6g Agrn Gpihbp1 Pnlip Apoa1 Rpe65 Clps Dhrs9 Myo7a Sdr9c7 Hsd17b6 Gpc6 Gpc4 Gpc2 Rbp4 Gnb5 Lrp1 Lrp10 Gnb1 Rbp2 Tex12 Rbp1 Lrp8 Abca4 Apom Lrp12 Lpl Bco1 Rdh11 Lrat Gpc1 Bco2 Cyp4v3 Gngt1 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS%REACTOME DATABASE ID RELEASE 66%10145358 Role of phospholipids in phagocytosis Prkcd Fcgr1a Cd247 Pla2g6 Pld1 Pik3r1 Pld2 Pld4 Pik3r2 Ppapdc1a Pld3 Pik3cb Cd3g Ppapdc1b Plcg1 Fcgr2b LOC103693683 Fcgr2a Syk Fcgr3a TRAF6-MEDIATED INDUCTION OF TAK1 COMPLEX WITHIN TLR4 COMPLEX%REACTOME DATABASE ID RELEASE 66%10145767 TRAF6-mediated induction of TAK1 complex within TLR4 complex Cd14 LOC100910771 Tab2 Tab3 Tab1 Tlr4 Ticam2 Map3k7 Traf6 TRKA ACTIVATION BY NGF%REACTOME DATABASE ID RELEASE 66%10145140 TRKA activation by NGF Ntrk1 Ngf AQUAPORIN-MEDIATED TRANSPORT%REACTOME DATABASE ID RELEASE 66%10145007 Aquaporin-mediated transport Myo5b Prkar2b Prkar2a Rab11fip2 Avp Aqp7 Prkar1b Gnb3 Aqp11 Prkar1a Gnb5 Aqp4 Mip Aqp12a Gnb2 Rab11a Gnb1 Gng13 Gng12 Aqp1 Gng11 Prkaca Prkacb LOC100912034 Gnb4 Gng4 Gngt2 Gng5 Gngt1 Gng10 Gng8 Gng3 CHK1 CHK2(CDS1) MEDIATED INACTIVATION OF CYCLIN B:CDK1 COMPLEX%REACTOME%R-RNO-75035.1 Chk1 Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex Wee1 Ywhah Ywhag Sfn Cdc25c Ywhaz Cdk1 Ywhab Chek2 Ywhaq Ywhae NEURONAL SYSTEM%REACTOME DATABASE ID RELEASE 66%10144791 Neuronal System Plcb1 Cacna1e Mdm2 Plcb3 Rims1 Gja10 Cplx1 Panx1 Syt1 Gjd2 Vamp2 Stxbp1 Kcnd3 Ppfia1 Ppfia2 Gjc1 Ppfia3 Kcnd1 Ppfia4 Slc38a2 Il1rap Maoa Slc22a1 Slc22a2 Aldh2 Comt Slc6a4 Slc6a3 Bche Lrtomt Chat Gnai3 Ache Slc1a3 Slc1a7 Slc1a6 Slc1a1 Kcnk6 Kcnk7 Nsf Myo6 Kcnj16 Flot1 Flot2 Rtn3 Chrne Kcnv2 Chrnd Kcnv1 Cacnb4 Stx1a Cacnb1 Cacng8 Cacnb2 Kcnq1 Cacna2d3 Prkca Cacng2 Ntrk3 Cacng3 Cacna2d2 Slc5a7 Cacng4 Dlg4 Grin2d Camk2g Grin2b Grm1 Grin1 Nefl Rasgrf1 Dlg1 Kcnmb4 Dlg2 Kcnmb3 Kcnn2 Kcnn3 Dlg3 Camk2d Actn2 Kcnmb2 Kcnmb1 Camk2a Lin7c Rps6ka2 Lin7a Rps6ka1 Syn3 Syn2 Rps6ka3 Lrrc4b Kcnn4 Chrna4 Kcnn1 Chrna5 Chrna9 Kcnma1 Lrfn2 Chrna6 Lrfn3 Chrnb2 Lrfn1 Chrna7 Lrfn4 Chrnb3 Syn1 Apba1 Chrna2 Chrna3 Chrna1 Ptprd Hcn1 Hcn3 Hcn2 Slitrk6 Slitrk5 Slitrk3 Slitrk2 Slitrk1 Ppfibp1 Ppfibp2 Ptprf Kcnk1 Kcnk13 Kcnk2 Kcnk3 LOC100909725 Kcnk4 Kcnk10 Gng10 Kcnk9 Rras Grip1 Grip2 Pick1 Lrrc7 Slc32a1 Slc38a1 Lin7b Gabra5 Gabra6 Gabrb1 Gabrg2 Gabra1 Gabra2 Kcnk18 Pdpk1 Naaa Gabra4 Gabrb2 Slc6a11 Dlgap2 Slc6a13 Dlgap3 Slc6a1 Dlgap4 Epb4.1l5 Slc6a12 Lrrtm2 Lrrtm3 Lrrtm4 LRRTM1 Raf1 Dlgap1 Ap2a2 Adcy8 Adcy9 Gad2 Adcy5 Adcy4 Kcnk16 Adcy7 Adcy6 Gad1 Abat Aldh5a1 Epb4.1 Gabrr1 Nrxn2 Shank1 Shank2 Gabrr3 Gabrr2 Nlgn1 Homer3 Nlgn2 Nlgn3 Homer2 Homer1 Epb41l2 Epb41l3 Gnal Rab3a Gnat3 Prkcb Kcnab2 Bzrap1 Ap2s1 Ap2a1 Ap2m1 Camkk1 Gnb3 Gnb5 Kcnc2 Gnb2 Gnb1 Gng13 Gng12 Gng11 Mapk1 Kcns3 Creb1 LOC100912034 Gnb4 Dbnl Camk4 Gng4 Gngt2 Gng5 Gngt1 Gng8 Gng3 Kcng4 Kcng3 Kcnq2 Kcna7 Chrnb4 Kcnb2 Kcns2 Kcnq3 Kcns1 Kcnh4 Kcnh3 Glra4 Kcnh2 Kcnab3 Kcna10 Htr3b Kcnf1 Htr3a Kcnh6 Glrb Kcnh5 Kcna1 Kcna2 Kcna5 Kcnc3 Kcnh1 Kcna4 Kcnj2 Kcnj3 Kcnj11 Kcnj14 Kcnj15 Glul Kcnj9 Abcc8 Cacna1b Kcnj5 Kcnj8 Gabbr1 Kcnj12 Gabbr2 Abcc9 Il1rapl1 Kcnj4 Kcnj6 Gria3 Gria4 Adcy3 Akap5 Dnajc5 Gnai2 Grik1 Grik3 Grik2 Ncald Grik5 Slc17a7 Rps6ka6 Hras Gnai1 SIGNAL REGULATORY PROTEIN FAMILY INTERACTIONS%REACTOME DATABASE ID RELEASE 66%10145430 Signal regulatory protein family interactions LOC100909977 Cd47 LOC100360575 Ptk2b Sirpa Tyrobp LOC100909879 Skap2 Grb2 Fyb RHO GTPASES ACTIVATE ROCKS%REACTOME%R-RNO-5627117.1 RHO GTPases Activate ROCKs Rock1 Rhoa Rock2 Rhob Rhoc TRIF(TICAM1)-MEDIATED TLR4 SIGNALING%REACTOME DATABASE ID RELEASE 66%10145138 TRIF(TICAM1)-mediated TLR4 signaling Map2k7 Ripk2 Tbk1 Map2k6 Ager Dusp3 Irf3 Map2k4 Map3k8 Dusp4 Nfkbib Traf6 Cul1 Vrk3 Rps6ka2 Rps6ka1 App Rps6ka3 Rps6ka5 LOC100912585 Tab1 Dusp7 Dusp6 Rela Atf1 Atf2 Map3k7 Irak2 Tlr4 Ikbke Tank Traf3 Nfkbia LOC100910771 Ube2n Jun Ppp2cb Ppp2ca Skp1 Ppp2r1a Ticam2 Nfkb2 Cd14 Nfkb1 Mapk9 Mapk8 Fos S100b Mapk7 Dhx9 Fbxw11 Chuk Ppp2r1b Mapkapk3 Btrc Mapkapk2 Mapk1 Nkiras1 LOC100362142 Nod1 Ptpn11 Nod2 Nkiras2 Creb1 Tab2 Tab3 LOC100912618 Ube2v1 Ikbkb Mapk14 Myd88 Tnip2 Mapk11 Mapk10 REGULATION OF TP53 DEGRADATION%REACTOME DATABASE ID RELEASE 66%10145361 Regulation of TP53 Degradation Usp7 Mdm2 Akt1 Ppp2r5c Ppp2cb Ppp2ca Ppp2r1a Ccna2 Ccna1 Rffl Ccng1 Phf20 Atm Rictor Mtor Usp2 Cdk2 Daxx LOC100910954 Cdk1 Ppp2r1b Mdm4 Mlst8 Chek2 Pdpk1 Rnf34 Mapkap1 Sgk1 Akt3 Akt2 VITAMIN B1 (THIAMIN) METABOLISM%REACTOME%R-RNO-196819.1 Vitamin B1 (thiamin) metabolism LOC100910173 Thtpa Tpk1 Slc19a2 Slc25a19 E3 UBIQUITIN LIGASES UBIQUITINATE TARGET PROTEINS%REACTOME%R-RNO-8866654.1 E3 ubiquitin ligases ubiquitinate target proteins Cdc73 LOC100910200 Hist1h2bh Ube2d1 Rtf1 LOC100912338 Leo1 Rnf40 Ube2d3 Ctr9 Hist1h2bq LOC100364835 Hist1h2bo Wdr61 Pex14 Hist1h2bcl1 Pex10 Pex13 Hist1h2bk Pex2 Pex12 Hltf Rad18 Pex5 Rraga Ube2a Pcna Rnf152 Ube2v2 Ube2n Shprh Bcl10 Rnf20 Hist1h2bg LOC103690024 LOC684797 Paf1 Hist1h2ba Rnf181 RESOLUTION OF D-LOOP STRUCTURES THROUGH SYNTHESIS-DEPENDENT STRAND ANNEALING (SDSA)%REACTOME DATABASE ID RELEASE 66%10146147 Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Bard1 Wrn Rbbp8 Rmi1 Rmi2 Rad51c LOC100911267 Rad51d Rad51 Brca2 Rad50 Rtel1 Xrcc3 Brca1 Blm Slc25a16 Palb2 Xrcc2 Nbn Atm Mre11a TWIK RELATED POTASSIUM CHANNEL (TREK)%REACTOME DATABASE ID RELEASE 66%10145838 TWIK related potassium channel (TREK) Kcnk2 Kcnk4 Kcnk10 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME DATABASE ID RELEASE 66%10145438 Regulation of beta-cell development Akt3 Foxo1 Akt1 Akt2 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND%REACTOME%R-RNO-69183.1 Processive synthesis on the lagging strand Rpa3 LOC100911727 Pold2 Pold1 Pcna Pold4 Rpa1 Slc25a16 Rpa2 Fen1 Prim2 Pola2 Prim1 Lig1 CARBOXYTERMINAL POST-TRANSLATIONAL MODIFICATIONS OF TUBULIN%REACTOME%R-RNO-8955332.1 Carboxyterminal post-translational modifications of tubulin Ttll9 Ttll4 Ttll5 Ttll3 Ttll7 Ttll2 Ttll10 Ttll12 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME DATABASE ID RELEASE 66%10145218 APC C:Cdc20 mediated degradation of mitotic proteins Psmc6 Psmb10 Psmb8 Psmb9 Psmb4 Psmb11 Bub3 Psmb5 Psmf1 Psmb6 Psmd4 Psmb2 Psmd5 Psmd8 Psmd9 Psmb3 Psma8 Psmd11 Psmd12 Anapc11 Ccna2 Ccna1 Anapc15 Psmd13 Anapc10 Psmd14 Psmc3 G6pc Ube2d1 Cdc20 Psmb7 Psmb1 Bub1b Mad2l1 Anapc7 Cdc26 Cdc27 Cdc23 Psma5 Pttg1 Ube2c Cdk1 Anapc16 Cdc16 Nek2l1 Anapc4 Psma2 Anapc2 Anapc1 Psmc5 Psmd2 Psma1 Psma4 Psmc1 Psma3 Psmc4 Psmc2 Psma6 Psme1 Nek2 Psmd1 Psme2 Psmd7 Psmd3 Psmd6 DEGRADATION OF AXIN%REACTOME DATABASE ID RELEASE 66%10146020 Degradation of AXIN Psmc6 Psmb10 G6pc Psmb8 Psmb9 Psmb4 Psmb11 Psmb5 Psmf1 Psmb6 Psmd4 Psmb2 Psmd5 Psmd8 Psmb7 Psmd9 Psmb1 Psmb3 Psma8 Psmd11 Psmd12 Psmd13 Psmd14 Tnks Psma5 Psma2 Psmc5 Psmc3 Psma1 Psmd2 Psma4 Psmc1 Psma3 Psmc4 Psmc2 Psma6 Psme1 Psmd1 Psme2 Tnks2 Psmd7 LOC100910717 Psmd3 Psmd6 DNA DAMAGE BYPASS%REACTOME DATABASE ID RELEASE 66%10144978 DNA Damage Bypass Rfc1 Rfc2 Pole2 Pole4 Polh Wdr48 Ddb1 Vcp Rbx1 Ns5atp9 Poli Zbtb32 Uba7 Usp43 Rev1 Rpa1 Rpa2 Ube2l6 Rchy1 Dtl Rpa3 Rad18 Pole Pold2 Pcna Pold1 Cul4b Pold4 Cul4a Usp1 Isg15 Trim25 Sprtn Rfc5 Nploc4 Usp10 Mad2l2 Rfc4 Rev3l Ufd1l Rfc3 SIGNALING BY ACTIVIN%REACTOME%R-RNO-1502540.1 Signaling by Activin Smad3 Fstl3 Smad2 Acvr2a Foxh1 Acvr1c Acvr1b Fst Inhba Drap1 CELL DIVISION%REACTOME%R-RNO-68884.1 cell division Stag1 Kif20a Kif23 Pds5b Pds5a Rad21 Smc1a Mau2 Stag2 Smc3 OAS ANTIVIRAL RESPONSE%REACTOME DATABASE ID RELEASE 66%10146284 OAS antiviral response Ddx58 Pde12 Oasl Rnasel Abce1 PKA-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%R-RNO-111931.1 PKA-mediated phosphorylation of CREB Adcy8 Adcy9 Adcy5 Adcy4 Adcy7 Adcy6 Prkar1b Prkar1a Prkaca Prkacb Adcy3 Prkar2b Prkar2a RHO GTPASES ACTIVATE WASPS AND WAVES%REACTOME DATABASE ID RELEASE 66%10145928 RHO GTPases Activate WASPs and WAVEs Wasf1 Arpc4 Abi1 Arpc3 Abi2 Potef Rac1 Nck1 Nckipsd LOC100361457 Actr3 Was Actr2 Arpc1b Cyfip1 Actb LOC100909750 Brk1 Baiap2 Cdc42 Mapk1 Arpc5 Wasl Nckap1l Wipf1 Ptk2 Wipf2 Wipf3 Actg1 Cyfip2 Nckap1 Abl1 Grb2 SNRNP ASSEMBLY%REACTOME%R-RNO-191859.1 snRNP Assembly Nup93 Nup43 Snrpf Nup98 Nup133 Nup107 Phax Aaas Nup155 Nup210 Snrpd1 Npap60 Snrpd2 Nup35 Snrpd3 Nup88 Snupn Nup37 Nupl2 Nupl1 Nup85 Nup153 Ncbp2 Ncbp1 Tpr Ddx20 Gemin7l1 Rae1 Tgs1 Gemin5 Gemin7 Gemin6 Nup54 Gemin8 Smn1 Pom121 Nup205 Ranbp2 Gemin2 Nup62 Snrpb CHROMOSOME MAINTENANCE%REACTOME DATABASE ID RELEASE 66%10145113 Chromosome Maintenance Rfc1 Cenpn Rfc2 Cenpl Cenpo Cenpt Pole2 Pole4 Cenpu Cenpk Cenph Cenpi Prim2 Pola2 Prim1 Cenpm Tinf2 Hist1h2bo Hist1h2bcl1 Hist1h2bk Rpa3 Pole Pcna Cenpc Cenpa Terf2ip Cenpw Ruvbl1 Smarca5 LOC100911204 Rfc5 Rfc4 Rfc3 Itgb3bp LOC100910200 H2afx Hist1h4b Mis18bp1 Acd Hist1h2bh LOC100912290 Rbbp7 Pot1b Hist1h4m LOC103690002 Tert LOC100910152 Pot1 LOC100912338 H2afb3 Rpa1 Hist2h4 Hjurp Rpa2 H2afj Hist2h2aa3 Hist1h2bq Hist2h2aa2 Casc5 LOC100364835 Lig1 LOC100911727 Terf1 Terf2 Pold2 Pold1 Pold4 Slc25a16 Fen1 Hist1h2bg LOC680097 LOC684797 LOC100912418 Hist1h2ba Hist3h2bb TRANSCRIPTIONAL REGULATION BY RUNX1%REACTOME DATABASE ID RELEASE 66%10146236 Transcriptional regulation by RUNX1 Psmc6 Psmb10 Psmb8 Psmb9 Psmb4 Psmb11 Psmb5 Psmf1 Psmb6 Mnat1 Psmd4 Psmb2 Psmd5 Psmd8 Csnk2a2 Psmd9 RGD1308751 Gata2 Psmb3 LOC100911167 Psma8 Psmd11 Psmd12 Csnk2a1 Tal1 Ldb1 Psmd13 Pml Psmd14 Tp73 Gata1 Actl6a Lmo2 Lmo1 Cts8l1 LOC100909750 Elf1 Elf2 Psmc3 Ccnh Yap1 Rbbp5 Actl6b Smarce1 Pbrm1 Arid1b Arid1a Zfpm1 Smarcd1 Hdac1 Smarcd2 Smarcd3 Foxp3 Ccnd1 Hipk2 Phc1 Phc2 MGC114246 Yaf2 Sin3a Sin3b Testin Prmt6 Hist1h2bo Scmh1 Hist1h2bcl1 Hist2h3c2 Cbx4 Hist1h2bk Cbx2 H3f3b Cbx8 Cbx6 Bmi1 Rnf2 Ring1 Smarca4 Hdac1l Prmt1 Smarca2 Phc3 LOC100911617 LOC100364523 Esr1 Arid2 Cbfb Gata3 Smarcc1 Smarcc2 Crebbp Smarcb1 Serpinb13 Cdk6 Abl1 Runx1 LOC100910200 Ccnd3 H2afx Hist1h4b Wdr5 Auts2 Kmt2a LOC684841 G6pc Pax5 Hist1h2bh Pcgf5 LOC100912290 Hist1h2ail1 Hist1h4m LOC102549173 LOC103690002 LOC100910152 Psmb7 LOC100912338 Hist1h3c Psmb1 H2afb3 Hist1h3f Ctsl Hist2h4 Ctsm LOC684819 Hist1h3a Ctsj H2afj RGD1564657 Hist2h2aa3 Hist1h2bq Ctsk Hist2h2aa2 Ctsq Ctsr Ash2l LOC100364835 Dpy30 LOC684762 Csnk2b Psma5 Cdk7 Psma2 Psmc5 Psmd2 Psma1 Psma4 Ptpn11 Psmc1 Psma3 Cts8 Psmc4 Cts7 Psmc2 Psma6 Psme1 Hist1h2bg Psme2 Psmd1 LOC680097 Psmd7 RGD1564827 LOC684797 LOC100912418 Hist1h2ba Psmd3 Hist3h2bb Psmd6 AFLATOXIN ACTIVATION AND DETOXIFICATION%REACTOME DATABASE ID RELEASE 66%10145070 Aflatoxin activation and detoxification Cyp3a23/3a1 Cyp3a73 Dpep2 Dpep3 Dpep1 Acy3 Akr7a2 Cyp3a18 LOC100910877 Ggt7 Ggt6 Cyp1a2 Mgst3 Mgst1 Acy1 SEROTONIN AND MELATONIN BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 66%10145426 Serotonin and melatonin biosynthesis Aanat Asmt Tph1 Tph2 Ddc N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI%REACTOME%R-RNO-975576.1 N-glycan antennae elongation in the medial trans-Golgi Mgat2 Mgat5 Man2a1 Fut8 Man2a2 Mgat4b Mgat3 Mgat4a B4galt1 Chst8 B4galt3 St6gal1 Lhb B4galt2 B4galt6 B4galt4 B4galt5 Chst10 St8sia3 St3gal4 Cga HYDROLYSIS OF LPE%REACTOME%R-RNO-1483152.1 Hydrolysis of LPE LOC686302 Pla2g4c Pla2g4cl1 ACTIVATED NTRK3 SIGNALS THROUGH PI3K%REACTOME%R-RNO-9603381.1 Activated NTRK3 signals through PI3K Src Ntrk3 Ntf3 SIGNAL TRANSDUCTION BY L1%REACTOME%R-RNO-445144.1 Signal transduction by L1 Csnk2b Ncam1 Egfr Nrp1 Rac1 Fgfr1 Mapk1 Csnk2a2 L1cam Pak1 Csnk2a1 Itga2b Vav2 Map2k2 PDE3B SIGNALLING%REACTOME%R-RNO-165160.1 PDE3B signalling Pde3b IRS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 66%10144880 IRS-mediated signalling Pik3r1 Pik3r2 Fgf23 Fgf22 Fgf4 Fgf1 Fgf3 Tlr9 Fgf6 Fgf5 Fgf20 Gab1 Pde3b Fgf16 Pik3c3 Fgf17 Irs2 Fgf10 Fgf9 Fgfr2 Fgf7 Fgf2 Fgf8 Fgfr3 Pik3r4 Trib3 Pdpk1 Fgfr1 Fgfr4 Pik3cb Ptpn11 Fgf19 Them4 Irs1 Frs2 Sos1 Akt2 Grb2 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE%REACTOME DATABASE ID RELEASE 66%10145154 Toll Like Receptor 7 8 (TLR7 8) Cascade Map2k7 Ripk2 Map2k6 Ager Dusp3 Map2k4 Map3k8 Dusp4 Peli3 Nfkbib LOC100912399 Peli2 Map3k1 Traf6 Cul1 Vrk3 Rps6ka2 Rps6ka1 App Rps6ka3 Rps6ka5 Tlr9 LOC100912585 Tab1 Dusp7 Dusp6 Rela Atf1 Atf2 Map3k7 Peli1 Irak2 Nfkbia LOC100910771 Ube2n Jun Ppp2cb Ppp2ca Skp1 Ppp2r1a Nfkb2 Nfkb1 Mapk9 Tlr7 Mapk8 Tlr8 Fos S100b Irak4 Mapk7 Dhx9 Fbxw11 Chuk Ppp2r1b Ecsit Mapkapk3 Btrc Mapkapk2 Dhx36 Mapk1 Nkiras1 LOC100362142 Nod1 Nod2 Nkiras2 Creb1 Tab2 Tab3 LOC100912618 Ube2v1 Ikbkb Mapk14 Myd88 Tnip2 Mapk11 Mapk10 ATP SENSITIVE POTASSIUM CHANNELS%REACTOME DATABASE ID RELEASE 66%10145831 ATP sensitive Potassium channels Kcnj11 Abcc8 Kcnj8 Abcc9 COOPERATION OF PDCL (PHLP1) AND TRIC CCT IN G-PROTEIN BETA FOLDING%REACTOME DATABASE ID RELEASE 66%10146196 Cooperation of PDCL (PhLP1) and TRiC CCT in G-protein beta folding Cct6b Gnai3 Rgs9 Csnk2a2 Gnat3 Gnao1 Cct6a Csnk2a1 Tcp1 Cct7 Rgs7 Cct4 Gnat2 Pdcl Gnaz Cct3 Csnk2b Gnai2 Gnb3 Gnb5 Cct2 Gnb2 Gnb1 Gng13 Gng12 Gng11 Gnat1 Cct8 LOC100912034 Gnb4 Gng4 Gngt2 Gnai1 Gng5 Gngt1 Gng10 Gng8 Gng3 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS%REACTOME DATABASE ID RELEASE 66%10145334 NRIF signals cell death from the nucleus Sqstm1 Ngf Aph1b Psenen Aph1a Ngfr LOC100911293 Psen2 Psen1 Traf6 Ncstn Itgb3bp CD209 (DC-SIGN) SIGNALING%REACTOME%R-RNO-5621575.1 CD209 (DC-SIGN) signaling Nfkb1 Kras Fyn Cd209a Raf1 Prkaca Prkacb Relb Rps6ka5 Pak2 Pak3 Pak1 Lyn Hras Cd209b Cd209e Rela Nras Crebbp Clec4m Icam2 ANTIMICROBIAL PEPTIDES%REACTOME%R-RNO-6803157.1 Antimicrobial peptides Slc11a1 RatNP-3b Try4 Ear1 RGD1306474 Bpifb2 Rnase17 Bpi Cd4 Atp7a LOC683849 Bpifa2 Rnase6 Np4 Bpifa1 Clu Prss2 Defa7 Defa11 Bpifb4 Pglyrp3b Defa10 Pglyrp3 Defa5 Bpifb6 Pglyrp4 Pglyrp2 Itln1 Eppin Bpifa2f Chga Bpifa5 Prss1 Reg3g Elane Defb26 Defb28 Ccr6 Defb30 Defb18 Pdzd11 Defb36 Defb14 Defb12 Atox1 Pla2g2a Defb29 LOC103690254 Defb49 Tlr10 Try10 Defb25 LOC100365995 Defb43 Defb44 Ctsg Rnase3 Rnase2 Art1 Defb13 Defb41 Defb1 Defb22 Defb23 Defb20 Defb21 LOC102554637 S100a8 Ltf Pglyrp1 Tlr2 VITAMIN C (ASCORBATE) METABOLISM%REACTOME DATABASE ID RELEASE 66%10145368 Vitamin C (ascorbate) metabolism Gsto2 Gsto1 Slc2a1 Cyb5r3 Slc23a2 Cyb5a DEUBIQUITINATION%REACTOME DATABASE ID RELEASE 66%10145726 Deubiquitination Usp7 Mdm2 Ddb2 Mysm1 Kat2a Yy1 Actr8 Keap1 Fkbp8 Stambp Uimc1 Actl6a Mcrs1 Actb Ino80 Brca1 Tomm70a Mul1 Tomm20 Ruvbl1 Usp8 Smad3 Smad2 Hist1h2aa Nedd8 Usp9x Ube2d1 Nlrp3 Usp47 Skp2 Usp48 Usp42 Becn1 Traf2 Usp20 Ripk2 Usp26 Usp21 Usp22 Traf6 Usp19 Usp37 Il33 Tab1 Usp30 Map3k7 Usp24 Usp25 Vdac1 Siah2 Traf3 Stam2 Nfkbia Usp14 LOC100910771 Usp18 Usp15 Usp11 Usp10 Ufd1l Stam Atxn3 G6pc Atxn7 Cdc20 Psmb7 Psmb1 Vdac2 Foxo4 Ino80e Ino80d Nfrkb Psma5 Rad23a Rad23b Psma2 Psmd2 Psmc2 Psmd1 Psmd7 Ino80b Psmd3 Ino80c Psmd6 Psmc6 Bard1 Wdr20 Pten Psmb10 Psmb8 Psmb9 Psmb4 Rnf123 Psmb11 Psmb5 Wdr48 Psmf1 Psmb6 Psmd4 Bre Psmb2 Psmd5 Psmd8 Psmd9 Psmb3 Brcc3 Psma8 Psmd11 Psmd12 Ccna2 Ccna1 Psmd13 Psmd14 Ccp110 Clspn Hif1a Rhot1 Psmc3 Uchl3 Bap1 Senp8 RGD1561252 Ptrh2 Asxl2 Tada3 Foxk2 Uchl5 Adrm1 Uchl1 Mat2b Babam1 Josd2 Josd1 Suds3 Tada2b Tnks Rce1 Nod1 Nod2 Usp3 Usp4 Usp5 Stambpl1 LOC100911959 Tnip2 Apc Otub1 Ide Otud3 Hist2h2ab Otud7b Vcp Zranb1 Ripk1 Ifih1 Vcpip1 Tnip1 RGD1565607 Otub2 LOC100911993 Tnfaip3 LOC689730 Tgfbr1 Bmyc Usp13 Polb Esr1 Ogt Gata3 Tnks2 LOC100910717 Birc3 Birc2 Cyld LOC100910107 Ddx58 Fam175b Hist2h2aa3 Hist2h2aa2 Usp33 Usp2 Fam175a LOC100910954 Cdk1 Mdm4 Taf10 Psmc5 Arrb1 Psma1 Psma4 Psmc1 Arrb2 Cdc25a Rhoa Psma3 Psmc4 Psma6 Psme1 Psme2 LOC100912059 Adrb2 Usp17l5 Taf9b AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS%REACTOME DATABASE ID RELEASE 66%10145371 AKT phosphorylates targets in the nucleus Akt3 Rps6kb2 Creb1 Foxo1 Nr4a1 Foxo3 Foxo4 Akt1 Akt2 INFLAMMASOMES%REACTOME DATABASE ID RELEASE 66%10145733 Inflammasomes Nlrp3 Aim2 Hsp90ab1 Txn1 Panx1 Sugt1 Pycard Bcl2 Nlrp1a Txnip Mefv Pstpip1 P2rx7 PROCESSING OF SMDT1%REACTOME%R-RNO-8949664.1 Processing of SMDT1 Pmpcb Pmpca MGC94335 Afg3l2 Micu3 Stoml2 Micu2 LOC100910779 Micu1 Yme1l1 Spg7 Phb2 LOC100362065 Ccdc109b Mcu COPII-MEDIATED VESICLE TRANSPORT%REACTOME%R-RNO-204005.1 COPII-mediated vesicle transport Areg Stx5 Bet1 Sec24a Sec24b Cnih1 Sec24d Trappc10 Ppp6c Cnih3 Cnih2 Trappc2l Tgfa Cd59 Trappc6a Sec23ip Trappc6b Lman1l LOC102555167 Ankrd28 Sec13 Sar1b Col7a1 Rab1b Rab1a Lman2 Ykt6 F8 Sec16a Sec24c Scfd1 Sec16b Lman1 Folr1 Trappc2 Trappc5 Tmed2 Ctsc Uso1 Napg Gorasp1 Ctsz Napb Napa Tfg Mcfd2 Preb Nsf Trappc3 LOC100910318 Sec22b Tbc1d20 Sec23a Sec31a Sec22a Stx17 Csnk1d Gosr2 Ppp6r3 LOC100363782 Ppp6r1 Tmed10 Trappc1 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME DATABASE ID RELEASE 66%10145773 IRAK2 mediated activation of TAK1 complex upon TLR7 8 or 9 stimulation LOC100910771 Tab2 Tab3 Tab1 Map3k7 Traf6 Irak2 BIOSYNTHESIS OF DPAN-3 SPMS%REACTOME%R-RNO-9025094.1 Biosynthesis of DPAn-3 SPMs Alox12 Alox5 Ptgs2 Alox15 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS%REACTOME DATABASE ID RELEASE 66%10144939 SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs Ncbp2 Slbp Snrpf Zfp473 Snrpd3 Ncbp1 Lsm10 Lsm11 Snrpb DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE%REACTOME%R-RNO-4641262.1 Disassembly of the destruction complex and recruitment of AXIN to the membrane Peg12 Frat2 Wnt8a Dvl1 LOC100361515 Wnt8b Fzd1 Lrp5 Lrp6 Dvl2 Wnt3 Dvl3 Fzd2 Wnt1 Wnt3a COLLAGEN DEGRADATION%REACTOME DATABASE ID RELEASE 66%10145855 Collagen degradation Mmp8 Mmp15 Mmp7 Col19a1 Mmp12 Mmp14 Mmp9 Col13a1 Try4 Mmp13 Mmp1 LOC103690254 Mmp2 Try10 LOC100365995 Ctsd Ctsb RGD1308751 Ctsm Ctsj Phykpl RGD1564657 Ctsk Ctsq Ctsr LOC683849 Furin Col18a1 MGC114246 Cts8l1 LOC102554637 Mmp20 Tmprss6 Prss2 LOC100364523 LOC100910122 Testin Cts8 Cts7 Col26a1 RGD1564827 Prss1 Mmp10 PROTEIN REPAIR%REACTOME%R-RNO-5676934.1 Protein repair Msrb2 Msrb3 Txn1 Msra ACROSOME REACTION%REACTOME%R-RNO-1300645.1 Acrosome Reaction Acr PKA ACTIVATION%REACTOME%R-RNO-163615.1 PKA activation Adcy8 Adcy9 Adcy5 Adcy4 Adcy7 Adcy6 Prkar1b Prkar1a Prkaca Prkacb Adcy3 Prkar2b Prkar2a PROCESSING OF INTRONLESS PRE-MRNAS%REACTOME DATABASE ID RELEASE 66%10144941 Processing of Intronless Pre-mRNAs Ncbp2 Ncbp1 Cpsf7 Papola Wdr33 Cpsf2 Cpsf3 Cpsf4 Pcf11 Cstf2t Fip1l1 Sympk Cstf1 Cpsf1 Nudt21 Clp1 Cstf2 NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 66%10145491 Netrin-1 signaling Mapk8 Src Fyn Mapk13 LOC100909609 Mapk12 Dscaml1 Dscam Prkcq Siah1 Dcc Rac1 Siah2 Cdc42 Ezr Nck1 Pak1 Wasl Dock1 Ptk2 Ntn1 Mapk14 Ntn4 Mapk11 FMO OXIDISES NUCLEOPHILES%REACTOME%R-RNO-217271.1 FMO oxidises nucleophiles Fmo1 Fmo2 ASTROCYTIC GLUTAMATE-GLUTAMINE UPTAKE AND METABOLISM%REACTOME%R-RNO-210455.1 Astrocytic Glutamate-Glutamine Uptake And Metabolism Slc1a3 Slc38a1 Glul RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES%REACTOME%R-RNO-380270.1 Recruitment of mitotic centrosome proteins and complexes Dync1i2 Tubgcp2 Cep57 LOC691918 Haus3 Ninl Akap9 Ccp110 Dync1h1 Pafah1b1 LOC103692716 Dctn1 Cntrl Dctn2 Cep76 Pcm1 Cep78 LOC100911033 Cep164 Dctn3 Cep41 Ofd1 Sdccag8 Tubb5 Prkar2b Cenpj Ywhag Ppp2r1a Plk4 Ywhae LOC100912076 Tubg2 Haus2 Haus1 Haus5 Alms1 Cdk11b Haus4 Clasp1 Odf2 Tubb4a Cdk1 Nek2l1 Ssna1 Mapre1 Tubg1 Cep63 Prkaca Csnk1d Cep131 Tuba4a Cep250 Cep135 Csnk1e Ckap5 Cdk5rap2 Nme7 Tubgcp5 Pcnt Nek2 Tubgcp6 Cep72 Tubgcp3 Sfi1 Tubgcp4 Cep70 Actr1a Mzt1 Nedd1 Mzt2b METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS%REACTOME%R-RNO-196849.1 Metabolism of water-soluble vitamins and cofactors Mmadhc Abcd4 Cd320 Slc46a1 Mmab Tcn2 Mmachc LOC683849 Ctrc Lmbrd1 Fasn Acacb Nnmt Slc5a6 Mccc2 Nt5e Pdzd11 Mtrr Hlcs Gsto1 Mccc1 LOC103690254 Mtr Mut Try10 LOC100365995 Cubn Amn Naprt1 Ptgs2 Mmaa Ptgis Try4 LOC688708 Rfk Pdxk LOC100911034 Apoa1bp Gsto2 Vnn1 Tpk1 Rnls Carkd Slc52a2 Slc52a3 Slc23a2 Pc Nampt Mocs1 Cd38 Enpp1 Parp14 LOC100910173 Nudt12 Nmnat2 Nmnat1 Acp5 Mocos Nmrk1 Prss2 Nmrk2 Nfs1 Nadsyn1 Cyb5a Pank4 Flad1 Coasy Parp9 Mocs3 Pank3 Pank2 Parp6 Ppcs RGD1563242 Thtpa Pank1 LOC100362038 Parp8 Aasdhppt Qprt Folr2 Slc19a2 Nadk Prss1 Slc25a19 Aox1 Pnpo Ppcdc Mthfs Mthfd1l Mthfd2l Dhfr LOC102554637 Mthfr Mthfd2 Slc5a8 Mthfd1 Shmt1 Aldh1l2 Aldh1l1 Slc19a1 Slc25a32 Cyp8b1 Shmt2 Bst1 Slc2a1 Pccb Cyb5r3 CELLULAR RESPONSE TO HYPOXIA%REACTOME%R-RNO-2262749.1 Cellular response to hypoxia Psmc6 Psmb10 Hif1an Psmb8 Vhl Psmb9 Psmb4 Psmb11 Psmb5 Psmf1 Psmb6 Psmd4 Psmb2 Rbx1 Psmd5 Psmd8 Psmd9 Psmb3 Psma8 Psmd11 Psmd12 Psmd13 Psmd14 Egln2 Tceb2 Tceb1 Cul2 Cited2 Hif1a Limd1 Psmc3 Epas1 Hif3a Egln3 Ajuba Crebbp G6pc Ube2d1 Psmb7 Psmb1 Ube2d3 Psma5 Arnt Psma2 Psmc5 Psmd2 Psma1 Psma4 Psmc1 Psma3 Psmc4 Psmc2 Psma6 Psme1 Psmd1 Psme2 Psmd7 Psmd3 Psmd6 PHOSPHOLIPASE C-MEDIATED CASCADE; FGFR4%REACTOME DATABASE ID RELEASE 66%10146101 Phospholipase C-mediated cascade; FGFR4 Fgf16 Fgf17 Fgf9 Fgf2 Fgf8 Fgfr4 Fgf23 Fgf4 Fgf1 Fgf6 Plcg1 Fgf19 Fgf20 CROSSLINKING OF COLLAGEN FIBRILS%REACTOME DATABASE ID RELEASE 66%10145923 Crosslinking of collagen fibrils Bmp1 Loxl4 Tll2 Lox Loxl1 Tll1 Pcolce CELL SURFACE INTERACTIONS AT THE VASCULAR WALL%REACTOME DATABASE ID RELEASE 66%10145033 Cell surface interactions at the vascular wall Cd44 Selplg Sele Itgam Igll1 Cd244 Selp Cd84 Glg1 Slc7a8 Slc7a9 Mmp1 Slc7a5 Slc7a6 Gas6 Slc7a7 Itgb2 Itga4 Slc7a10 Vpreb2 Itga6 Vpreb1 Slc16a3 Sdc2 Vpreb3 Jam3 Sdc3 Slc16a8 Sdc4 Slc16a1 Epcam Mertk Esam Cd48 Mif Trem1 Ceacam1 Cd47 Fyn Apob Thbd Procr Itgal Tgfb1 F2 Itgax LOC100909879 Kras Grb7 Pf4 Dok2 Bsg Pik3r1 Pik3r2 F11r L1cam Cd74 LOC100360575 Sirpa Atp1b3 Fn1 Atp1b2 LOC100909977 Atp1b1 Fcer1g Itga3 Slc7a11 LOC288521 Pik3cb Ppil2 Tek Ptpn11 Pros1 Spn LOC100361537 Lyn Angpt1 Hras Nras Gpc1 Sos1 Mag Angpt2 Angpt4 Ceacam10 Shc1 Grb2 FORMATION OF THE EDITOSOME%REACTOME DATABASE ID RELEASE 66%10144942 Formation of the Editosome Apobec1 Apobec2 A1cf Apobec4 ACTIVATION OF NOXA AND TRANSLOCATION TO MITOCHONDRIA%REACTOME DATABASE ID RELEASE 66%10145050 Activation of NOXA and translocation to mitochondria Pmaip1 REGULATION OF THYROID HORMONE ACTIVITY%REACTOME DATABASE ID RELEASE 66%10145423 Regulation of thyroid hormone activity SODIUM-COUPLED SULPHATE, DI- AND TRI-CARBOXYLATE TRANSPORTERS%REACTOME DATABASE ID RELEASE 66%10145648 Sodium-coupled sulphate, di- and tri-carboxylate transporters Slc13a4 Slc13a1 Slc13a2 Slc13a3 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1%REACTOME%R-RNO-174178.1 APC C:Cdh1 mediated degradation of Cdc20 and other APC C:Cdh1 targeted proteins in late mitosis early G1 Psmc6 Psmb10 Psmb8 Psmb9 Psmb4 Psmb11 Psmb5 Psmf1 Psmb6 Psmd4 Psmb2 Psmd5 Psmd8 Psmd9 Psmb3 Psma8 Psmd11 Psmd12 Anapc11 Anapc15 Psmd13 Aurka Anapc10 Psmd14 Fzr1 Aurkb Psmc3 G6pc Ube2d1 Cdc20 Psmb7 Psmb1 Anapc7 Cdc26 Cdc27 Psma5 Cdc23 Pttg1 Ube2c Skp2 Anapc16 Cdc16 Anapc4 Psma2 Anapc2 Anapc1 Psmc5 Psmd2 Psma1 Psma4 Psmc1 Psma3 Psmc4 Psmc2 Psma6 Psme1 Psmd1 Psme2 Psmd7 Psmd3 Psmd6 BIOSYNTHESIS OF DPAN-3-DERIVED 13-SERIES RESOLVINS%REACTOME%R-RNO-9026403.1 Biosynthesis of DPAn-3-derived 13-series resolvins Alox5 TP53 REGULATES TRANSCRIPTION OF DEATH RECEPTORS AND LIGANDS%REACTOME%R-RNO-6803211.1 TP53 Regulates Transcription of Death Receptors and Ligands O2 CO2 EXCHANGE IN ERYTHROCYTES%REACTOME DATABASE ID RELEASE 66%10145818 O2 CO2 exchange in erythrocytes Cyb5r2 Cyb5rl Rhag Hbb-b1 Hba1 Car2 Aqp1 Slc4a1 Cyb5r1 Car1 LOC287167 FGFR2B LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 66%10145290 FGFR2b ligand binding and activation Fgf22 Fgf1 Fgf3 Fgf10 Fgfbp3 Fgfbp1 Fgfr2 Fgf2 Fgf7 RAF ACTIVATION%REACTOME DATABASE ID RELEASE 66%10146124 RAF activation Map3k11 Kras Src Ksr1 Ppp2r5e Raf1 Ppp2r1b Mark3 LOC100909468 Araf Ppp2r5c Ppp2cb Ppp2r5a Ppp2ca Ppp2r1a Ppp2r5b Hras Nras Ywhab Map2k2 ARMS-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 66%10145180 ARMS-mediated activation Ntrk1 Ngf Kidins220 Crk Rap1a GRB2 EVENTS IN EGFR SIGNALING%REACTOME%R-RNO-179812.1 GRB2 events in EGFR signaling Kras Hras Nras Egfr Sos1 Grb2 HS-GAG BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 66%10145730 HS-GAG biosynthesis Gpc6 Agrn Hs3st3a1 Gpc4 Gpc2 Ndst1 Ndst2 Ndst3 Ext1 Ndst4 Ext2 Hs6st2 Slc35d2 Hs3st3b1 Hs2st1 Hs3st5 Sdc2 Sdc3 Gpc1 Hs6st1 Sdc4 Hs3st2 Hs3st1 Hs3st6 STAT6-MEDIATED INDUCTION OF CHEMOKINES%REACTOME%R-RNO-3249367.1 STAT6-mediated induction of chemokines Tbk1 Stat6 Tmem173 DEGRADATION OF GABA%REACTOME DATABASE ID RELEASE 66%10145745 Degradation of GABA Abat Aldh5a1 BIOSYNTHESIS OF E-SERIES 18(R)-RESOLVINS%REACTOME DATABASE ID RELEASE 66%10146300 Biosynthesis of E-series 18(R)-resolvins Gpx4 Alox5 Alox15 Lta4h DNA DOUBLE STRAND BREAK RESPONSE%REACTOME%R-RNO-5693606.1 DNA Double Strand Break Response Bard1 Ppp5c Bre Rad50 Brcc3 Pias4 Uimc1 Atm Hist1h2bo Hist1h2bcl1 Hist1h2bk LOC100909750 Kdm4b Kdm4a Sumo1 Brca1 Bap1 Mdc1 Ube2v2 Ube2n Ube2i Smarca5 Nbn Abl1 Mre11a LOC100910200 Whsc1 H2afx LOC100359600 Hist1h4b Rnf8 Hist1h2bh LOC100912290 Eya3 Apbb1 Babam1 LOC686349 Tp53bp1 Eya2 Hist1h4m Eya4 LOC100912338 Herc2 Hist2h4 Hist1h2bq LOC100364835 Baz1b Mapk8 Fam175a LOC100910954 Chek2 Hist1h2bg LOC680097 LOC684797 LOC100912418 Hist1h2ba Hist3h2bb Kpna2 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN%REACTOME DATABASE ID RELEASE 66%10145192 Regulation of Glucokinase by Glucokinase Regulatory Protein Nup93 Nup43 Nup98 Nup133 Nup107 Tpr Aaas Nup155 Rae1 Nup210 Npap60 Nup54 Nup35 Nup88 Nup37 Pom121 Nupl2 Nup205 Ranbp2 Gckr Nup62 Nupl1 Nup85 Nup153 CYTOSOLIC SULFONATION OF SMALL MOLECULES%REACTOME%R-RNO-156584.1 Cytosolic sulfonation of small molecules Bpnt1 Abhd14b Slc35b2 Sult6b1 Podxl2 Sult4a1 Sult2a1 Slc35b3 Papss2 Papss1 LOC100910526 RGD1562392 ste2 Impad1 Slc26a2 Tpst1 Slc26a1 Tpst2 Sult2b1 NEWGENE_1306455 LOC100910057 Sult1b1 LOC100910881 Sult1a1 Sult1c2 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS%REACTOME%R-RNO-264870.1 Caspase-mediated cleavage of cytoskeletal proteins Casp3 Vim Mapt Casp6 Dbnl Add1 Plec Gas2 Gsn Sptan1 Casp8 DISPLACEMENT OF DNA GLYCOSYLASE BY APEX1%REACTOME%R-RNO-110357.1 Displacement of DNA glycosylase by APEX1 Tdg Mpg Ogg1 Mbd4 Smug1 Ung Apex1 Nthl1 Mutyh NICOTINAMIDE SALVAGING%REACTOME%R-RNO-197264.1 Nicotinamide salvaging Nnmt Parp14 Nudt12 Ptgis Slc5a8 Cyp8b1 Parp9 Apoa1bp Parp6 Naprt1 Parp8 Rnls Carkd Ptgs2 Nampt TELOMERE MAINTENANCE%REACTOME DATABASE ID RELEASE 66%10145112 Telomere Maintenance Rfc1 Rfc2 Pole2 Pole4 Prim2 Pola2 Prim1 Hist1h2bo Tinf2 Hist1h2bcl1 Hist1h2bk Rpa3 Pole Pcna Terf2ip Rfc5 Rfc4 Rfc3 LOC100910200 H2afx Hist1h4b Acd Hist1h2bh LOC100912290 Pot1b Hist1h4m Tert LOC103690002 LOC100910152 Pot1 LOC100912338 H2afb3 Rpa1 Hist2h4 Rpa2 H2afj Hist2h2aa3 Hist1h2bq Hist2h2aa2 Lig1 LOC100364835 Terf1 LOC100911727 Terf2 Pold2 Pold1 Pold4 Slc25a16 Fen1 Hist1h2bg LOC680097 LOC684797 LOC100912418 Hist1h2ba Hist3h2bb RECYCLING OF EIF2:GDP%REACTOME%R-RNO-72731.1 Recycling of eIF2:GDP Eif2s3 Eif2b5 Eif2b3 Eif2b4 Eif2s1 Eif2s2 Eif2b1 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE%REACTOME DATABASE ID RELEASE 66%10144920 Cytochrome P450 - arranged by substrate type Nr1h4 Cyp1b1 Cyp4a2 Cyp4a1 Ptgis Rxra Cyp4a8 Cyp19a1 Fdx1l Cyp2j10 Por Cyp7b1 LOC100360055 Cyp7a1 Cyp21a1 Fdxr Cyp46a1 Cyp2r1 Cyp4f17 Ncoa1 Cyp4f18 Cyp2b2 Cyp2c24 Cyp2s1 Cyp2b1 Cyp4f39 Tbxas1 Cyp39a1 Pomc Cyp2b3 Cyp2d5 Cyp26c1 Cyp51 Fdx1 LOC100361492 Ahr Cyp11b2 LOC100910127 Cyp27b1 Cyp2c13 LOC100361547 Cyp3a23/3a1 Ncoa2 Cyp3a73 Cyp2b21 Arnt Cyp4f6 Cyp2u1 Cyp8b1 LOC100911763 Cyp2c7 Cyp2b15 Cyp2e1 Cyp2b12 LOC100912391 Cyp2d4 Cyp24a1 Cyp2f4 Cyp3a18 Cyp26a1 Cyp1a1 LOC100910877 Cyp2d2 Arnt2 Cyp4v3 Cyp1a2 Cyp26b1 Cyp2d3 Cyp2c6v1 UB-SPECIFIC PROCESSING PROTEASES%REACTOME%R-RNO-5689880.1 Ub-specific processing proteases Psmc6 Wdr20 Pten Psmb10 Usp7 Mdm2 Ddb2 Psmb8 Psmb9 Rnf123 Psmb4 Psmb11 Psmb5 Kat2a Psmf1 Wdr48 Psmb6 Psmd4 Psmb2 Psmd5 Psmd8 Keap1 Psmd9 Psmb3 Fkbp8 Psma8 Psmd11 Psmd12 Ccna2 Ccna1 Psmd13 Psmd14 Ccp110 Clspn Hif1a Rhot1 Psmc3 Tomm70a Ptrh2 Mul1 Tada3 Tomm20 Ruvbl1 Adrm1 Mat2b Usp8 Smad3 Smad2 Usp9x Suds3 Tada2b Tnks Usp47 Usp48 Skp2 Rce1 Usp42 Becn1 Traf2 Usp3 Usp4 Usp5 LOC100911959 Usp20 Usp26 Usp21 Usp22 Otub1 Ide Traf6 Usp19 Usp37 Il33 Tab1 Usp30 Ripk1 Ifih1 RGD1565607 Map3k7 LOC100911993 Usp24 Usp25 Vdac1 LOC689730 Tgfbr1 Bmyc Usp13 Polb Siah2 Stam2 Nfkbia Usp14 LOC100910771 Gata3 Usp18 Usp15 Tnks2 Usp11 Usp10 LOC100910717 Ufd1l Birc3 Birc2 G6pc Cyld Atxn7 Cdc20 LOC100910107 Psmb7 Ddx58 Psmb1 Vdac2 Foxo4 Usp33 Usp2 Psma5 LOC100910954 Mdm4 Taf10 Psma2 Psmc5 Arrb1 Psma1 Psmd2 Psma4 Psmc1 Arrb2 Cdc25a Psma3 Psmc4 Psma6 Psmc2 Psme1 Psme2 Psmd1 Psmd7 LOC100912059 Adrb2 Psmd3 Usp17l5 Taf9b Psmd6 O-GLYCOSYLATION OF TSR DOMAIN-CONTAINING PROTEINS%REACTOME DATABASE ID RELEASE 66%10146044 O-glycosylation of TSR domain-containing proteins Adamts13 Adamts15 Adamts19 Pofut2 Adamts16 Adamts17 Adamts4 Adamts3 Adamts5 Adamts12 Sema5a Spon2 Spon1 Adamts1 Adamts6 Adamts7 Adamts9 Sspo Cfp Adamts14 Sema5b Thbs2 Thsd7a Thbs1 Adamtsl2 Adamtsl3 Thsd1 Adamtsl4 Thsd7b LOC102554393 Sbspon TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT%REACTOME DATABASE ID RELEASE 66%10144895 Transport of Mature mRNA derived from an Intron-Containing Transcript Nup93 Rnps1 Thoc5 RGD1565693 Thoc7 Thoc3 Nup43 Thoc2 Nup98 Nup133 Thoc1 Nup107 Magohb Aaas Rbm8a Thoc6 Nup210 Npap60 Nxf7 Nup35 Gle1 Nxf2 Nup37 Nxf1 Nupl2 Ddx39a Nupl1 Ddx39b Chtop U2af1l4 Sarnp Tcp11x2 Nup205 Nxt1 Ranbp2 Slu7 Srsf3 Upf3b U2af2 Srsf6 Nup155 Srsf7 Srsf4 Srsf5 Srsf2 LOC679894 Nup88 Srsf9 Dhx38 Nup85 Magoh Nup153 Ncbp2 Srsf1 Poldip3 Ncbp1 Tpr Fyttd1 Rae1 Eif4a3 LOC100910660 Srrm1 Nup54 Pom121 Nup62 Cdc40 LOC361990 MET ACTIVATES PI3K AKT SIGNALING%REACTOME%R-RNO-8851907.1 MET activates PI3K AKT signaling Gab1 Hgf Pik3r1 Grb2 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME DATABASE ID RELEASE 66%10145957 NOTCH2 intracellular domain regulates transcription Notch2 Maml1 Rbpj Rbpjl2 RET SIGNALING%REACTOME DATABASE ID RELEASE 66%10146221 RET signaling Src Grb7 Dok2 Pik3r3 Pik3r1 Pik3r2 Rap1gap Gfra4 LOC100912585 Gfra3 Gfra2 Dok4 Dok1 Dok6 Pik3cd Dok5 Artn Gab1 Shc3 Nrtn Mapk7 Irs2 Ret Prkaca Grb10 Pik3cb Prkacb Ptpn11 Prkca Gdnf Plcg1 Frs2 Pdlim7 Sos1 Shc1 Pspn Grb2 CLATHRIN-MEDIATED ENDOCYTOSIS%REACTOME DATABASE ID RELEASE 66%10146228 Clathrin-mediated endocytosis Igf2r Egfr Syt1 Vamp2 Dnm2 Ap2a2 Cttn Cops8 Amph Cops2 LOC100361515 Bin1 Nedd8 Synj1 Fnbp1 Wnt5a Cltc Cltb Clta Fzd4 Synj2 Ap2s1 Cops4 Cops6 Ap2a1 Ap2m1 Cops3 Rab5b Rab5c Pacsin2 Pacsin3 Pik3c2a Gak Agtr1b Agtr1a Syt11 Aak1 Sgip1 Eps15l1 LOC100909548 Itsn2 Scarb2 Necap1 Agfg1 Snap91 Snx18 Ubqln2 Picalm Tgoln2 Ldlr Tor1a Hip1r Ston2 LOC100909679 Tfrc RGD1307443 Tf Chrm2 Necap2 Cd4 Snx9 Fnbp1l Tor1b Avp Dab2 Ston1 Pip5k1c Gapvd1 Cbl Arf6 Hip1 Vamp8 LOC100910792 Stam2 Sh3gl2 Apob Sh3gl1 Sh3kbp1 Wasl Sh3gl3 Ocrl Stam Arpc4 Arpc3 Itsn1 Arfgap1 Actr3 Actr2 Dnm1 Dnm3 Cops7b Cops7a Arrb1 Cd3g Dvl2 Slc2a8 Syt8 Arrb2 Cd3d Syt9 Syt2 Arpc5 Fcho2 Fcho1 M6pr Ldlrap1 Adrbk1 Vamp4 Vamp3 Adrb2 Vamp7 Tacr1 Grb2 FGFR2 ALTERNATIVE SPLICING%REACTOME%R-RNO-6803529.1 FGFR2 alternative splicing RGD1565904 Hnrnph1 Polr2g Polr2h Polr2e Polr2f Polr2j Polr2k Polr2d LOC100911822 Polr2i Polr2b Polr2c Polr2a Ncbp2 Esrp2 LOC100912534 Gtf2f1 Esrp1 Gtf2f2 Rbfox2 Tia1 Ncbp1 Tial1 Hnrnpm Hnrnpf NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME DATABASE ID RELEASE 66%10145624 Negative epigenetic regulation of rRNA expression LOC100910200 H2afx Hist1h4b LOC684841 Hist1h2bh LOC100912290 Hist1h2ail1 Hist1h4m LOC102549173 LOC103690002 LOC100910152 LOC100912338 Hist1h3c H2afb3 Hist1h3f Hist2h4 LOC684819 Hist1h3a H2afj Rrp8 Hist2h2aa3 Hist1h2bq Suv39h1 Hist2h2aa2 LOC100364835 LOC684762 Hist1h2bo Hist1h2bcl1 Hist2h3c2 Hist1h2bk H3f3b Hist1h2bg Mbd2 LOC680097 LOC684797 LOC100912418 Hist1h2ba Suv39h1l1 Hist3h2bb C-TYPE LECTIN RECEPTORS (CLRS)%REACTOME%R-RNO-5621481.1 C-type lectin receptors (CLRs) Psmc6 Psmb10 Psmb8 Psmb9 Psmb4 Raf1 Psmb11 Psmb5 Psmf1 Psmb6 Psmd4 Psmb2 Psmd5 Psmd8 Psmd9 Psmb3 Psma8 Psmd11 Psmd12 Psmd13 Psmd14 Fyn Psmc3 Il1b Ube2n Bcl10 Src Ube2d1 Skp1 Ppp3r1 Nfkb2 Nfkb1 Fbxw11 Chuk Btrc Prkaca Prkacb LOC100362142 Tab2 Tab3 LOC100912618 Lyn Ube2v1 Ikbkb Traf6 Cul1 Rps6ka5 Tab1 Cdc34 Rela Map3k7 Ube2m Pak2 Nfkbia Pak3 LOC100910771 Pak1 Pycard Crebbp Prkcd Kras G6pc Psmb7 Psmb1 Cd209b Cd209e Clec4m Casp8 Psma5 Cd209a Pdpk1 Psma2 Psmc5 RGD1560225 Psma1 Uba3 Psmd2 Ppp3ca Psma4 Nfatc2 Map3k14 Relb Psmc1 Psma3 Psmc4 Psma6 Psmc2 Psme1 Psmd1 Hras Psme2 Psmd7 Nras Nfatc3 Icam2 Psmd3 Psmd6 TRANSPORT OF CONNEXINS ALONG THE SECRETORY PATHWAY%REACTOME DATABASE ID RELEASE 66%215126 Transport of connexins along the secretory pathway Gja1 BICARBONATE TRANSPORTERS%REACTOME DATABASE ID RELEASE 66%10145616 Bicarbonate transporters Slc4a7 Ahcyl2 Slc4a9 Slc4a4 Slc4a3 Slc4a8 Slc4a2 Slc4a10 Slc4a5 Slc4a1 HEMOSTASIS%REACTOME DATABASE ID RELEASE 66%10145028 Hemostasis Selplg Kif21a Sele Kif21b Igll1 Kifc1 Cd244 Kif3c Racgap1 Kif22 Kif3b Cd84 Kif23 Glg1 Kif18b Kifap3 Kif11 Kif12 Gnaq Kif4a Kif6 Gna11 Kif1a Gna14 Kif1c Gna15 Nos3 Itga4 Serpine1 Kif27 Vpreb2 Itga6 Kif9 Vpreb1 Vpreb3 Kif13b Epcam Mertk Esam Cd48 Ptgir Fyn LOC497963 Cd9 Gnai3 Bsg Zfpm1 F11r Dock7 Akt1 Hdac1 Pdgfa Brpf3 Pdgfb Timp1 Nos1 Abcc4 A2m Tfpi F3 Itga3 G6b LOC288521 P2rx2 Kif20b P2rx3 Kif16b Ppil2 Kif26a P2rx5 P2rx6 Kif20a Kif26b Kif19 Plg P2rx4 Prkca Spn LOC100361537 Lyn Rhob Ceacam10 Syk Itgam Atp2b4 Sparc Atp2b2 Atp2b1 Mmp1 Actn2 Itgb2 App Atp2a2 Jam3 Atp2a3 Pde1b Ceacam1 Cd63 Prkcq Fgb Fgg Hgf Thbs1 Plaur Apob Thbd Fga F13b Procr Itgal LOC100909879 Itgax Qsox1 Actn1 Gng10 LOC685953 Pde9a Pde5a Cd36 Pde3a Tbxa2r Klkb1 L1cam Pafah2 Gna12 Vav2 Prkg2 Gna13 Vav1 Pde2a Cyct F12 Mrvi1 F11 Pde10a Serpina5 Pde11a C1qbp Atp1b3 Fn1 Atp1b2 LOC100909977 LOC100909700 Atp1b1 Csk Vav3 Rasgrp1 Rap1a Fcer1g Ptpn6 Itga2b Trpc3 Trpc7 Trpc6 Rad51c Raf1 Sh2b1 Ptpn1 Gata2 LOC100911167 Gata1 Cd47 Prkar1b Rasgrp2 Prkar1a Kif3a Gp1ba Gp9 Gp5 Gp1bb LOC100911551 F2rl3 Tgfb2 F2r Tgfb1 F2 F8 F7 Tgfb3 F9 F2rl2 Pik3r5 Pf4 Pik3r3 Pik3r6 Gnat3 Mapk1 Mapk14 Itpk1 Pla2g4a Trem1 Hist2h3c2 H3f3b Hdac2 Hdac1l LOC684841 Hist1h2ail1 LOC102549173 Hist1h3c Cd74 Hist1h3f Prkar2b Prkar2a LOC684819 Hist1h3a LOC684762 Arrb1 Tuba4a Arrb2 Lat Mag Lcp2 Stxbp3 Tex264 F13a1 Ola1 Klc1 Ly6g6f Ctsw Selp Serpina4 Slc7a8 Pcyox1l Tor4a Slc7a9 Islr Sri Cdc37l1 Chid1 Slc7a5 Fam3c Slc7a6 Lhfpl2 Slc7a7 Nhlrc2 Itih4 Mmrn1 Rarres2 Itih3 Slc7a10 Lefty2 Ecm1 Anxa5 Klc4 Tagln2 Gtpbp2 Kdm1a Timp3 Lefty1 Cenpe LOC100910414 Klc2 Plek Sccpdh Klc3 P2rx7 Phactr2 Mfn1 Slc8a3 Mfn2 LOC100911485 Kng1l1 A1bg Stx4 Plat Ptk2 Slc8a2 Slc8a1 LOC100909609 Aplp2 Figf Vegfc Vegfb Apoa1 Pik3cg Tln1 Crk Vwf Apbb1ip Bcar1 Slc7a11 Actn4 Vegfa Habp4 Pcdh7 Apool Apoh Wdr1 Srgn LOC100911881 Dock1 Lgals3bp Sytl4 Gpc1 LOC100912012 Fermt3 Cyb5r1 Maged2 Sod1 Aldoa Flna Clu Serping1 Rac2 Aldoart2 Kif2a Kif2c Kif2b Kif18a Kng1 Capzb Kif5b Kif5a Kng2 Serpinb8 Serpine2 S100a10 Serpinb2 Pdpk1 Cdc42 Pros1 Cd44 Dock5 Psap Dock3 Serpinb6b Rcor1 Dock9 Dock8 Dock6 Mical1 Lrrc16a Rac1 Akap1 Gata4 Slc16a3 Sdc2 Sdc3 Slc16a8 Sdc4 Slc16a1 Lamp2 Mif Cfd Serpind1 Adra2b Serpinb6 Dock11 Ehd3 Ehd2 Ehd1 Serpinc1 Hmg20b Phf21a Mafk Mafg Maff Cbx5 Nfe2 Akap10 Ak3 Anxa2 Rbsn Jmjd1c Zfpm2 Src Cd109 Rab27b Dgkk Dgki Cd177 Prkcb Ywhaz Dgkg Dgkd Dgke Dgka Dgkb Gnb3 Gnb5 Capza2 Gnb2 Gnb1 Gng13 Gng12 Gng11 Prkaca Prkacb Itpr1 Rapgef4 Dgkz Itpr3 Dgkq LOC100912034 Gnb4 Dgkh Gng4 Sh2b2 Gngt2 Serpina3m Gng5 Prkch Gngt1 Gng8 Gng3 Plau Vcl Gas6 Tf Mgll Abhd12 Daglb Abhd6 Dagla P2rx1 Pde3b Igf2 Igf1 RGD1565355 Gata3 Prkcd P2ry1 Kras Grb7 Dok2 Scg3 Pik3r1 Pik3r2 Stxbp2 LOC100360575 Sirpa LOC299277 P2ry12 Adra2a Fgr Gnai2 Adra2c Ppbp Lrp8 Pik3cb Tek Ptpn11 Rhoa Prcp Angpt1 Hras Nras Gnai1 Sos1 Rhog Angpt2 Angpt4 Shc1 Grb2 BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS%REACTOME%R-RNO-111453.1 BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members Bcl2l11 Bcl2 Bid Bmf Bad Pmaip1 POSITIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%R-RNO-5250913.1 Positive epigenetic regulation of rRNA expression Myo1c Kat2a RGD1565904 Polr1b Taf1d Polr2h Taf1c Cd3eap Polr2e Znrd1 Polr2f Polr1c Polr1a Polr2k Hist1h2bo Hist1h2bcl1 Hist2h3c2 LOC100912534 Hist1h2bk Actb H3f3b Sf3b1 Smarca5 Tbp LOC100910200 H2afx Hist1h4b LOC684841 Hist1h2bh LOC100912290 Hist1h2ail1 Hist1h4m LOC102549173 Mybbp1a LOC103690002 LOC100910152 LOC100912338 Hist1h3c H2afb3 Hist1h3f Ercc6 Hist2h4 LOC684819 Hist1h3a H2afj Hist2h2aa3 Hist1h2bq Hist2h2aa2 Ddx21 LOC100364835 Baz1b LOC684762 Twistnb Polr1e Hist1h2bg LOC680097 LOC684797 LOC100912418 Hist1h2ba Hist3h2bb Dek DEGRADATION OF CYSTEINE AND HOMOCYSTEINE%REACTOME DATABASE ID RELEASE 66%10145890 Degradation of cysteine and homocysteine Mpst Txn2 Suox Sqrdl Ethe1 Cdo1 Cth Tstd1 Tst Slc25a10 TRANSPORT OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 66%10144953 Transport of small molecules Trpc4ap Atp6v1g1 Atp6v1g2 Atp6v0a4 Atp6v1b2 Abca1 Atp6v0a2 Zdhhc8 Atp6v1h Atp6v1f Aqp11 Cygb Aqp4 Mip Aqp12a Car2 Aqp1 Car1 Slc22a1 Slc22a2 Slc6a3 Slc35c1 Nr1h3 Nedd8 Nr1h2 Bsg Slc5a1 Atp6v0d1 Atp6v1c2 Atp6v0d2 Myo5b Rab11fip2 Atp6v1a Slc2a2 Atp6v0e2 Atp6v0e1 Atp6v1g3 Atp6v1e1 Atp6v1e2 Atp6v1c1 Abcd2 Abcc4 Abcc2 A2m Abcc6 Aqp7 Abcd3 Abcb8 Abcb9 Derl3 Erlin2 Abcb10 Rnf5 Pex3 Abcb5 Abcb6 Abca4 Abca3 Abcf1 Abca2 Abcc10 Erlin1 Abca6 Abca5 Abcg4 Abcg1 Abcb1a Abca7 Abcg8 Abcg5 Scnn1b Camk2g Best1 Best3 Best2 Atp2b4 Scnn1g Tpcn2 Scnn1a Clcn4 Unc79 Atp2b2 Atp2b1 Slc9b1 Camk2d Clcn7 Cul1 Clcn6 Camk2a Clcn5 Ano10 Wwp1 Ano3 Clic2 Asic4 Asic5 Hbb-b1 Ano1 Trdn Atp7a Atp2a2 Atp7b Best4 Pln Clcnkb Asic3 Atp2a3 Lcat Lipg Pltp Slc9b2 Sar1b Apob Apoc2 Apoe Apoa2 Mttp Gng10 Slc5a11 Slc2a13 Slc17a3 Fxyd2 Sgk2 Fxyd3 Fxyd4 Sgk3 Atp10b Clcn1 LOC100912455 Wnk4 Atp11c Sln Ostm1 Wnk1 Wnk2 Wnk3 Psmb7 Psmb1 Atp9b Clcn2 Fxyd6 Atp10d Stom Fxyd7 Atp1b3 Atp1b2 Atp6v0a1 P4hb Clca4 Atp1b1 Psma5 Trpv4 Fkbp1b Trpv5 Atp8b3 Trpv6 Atp8b2 Atp8b1 Ano9 Ryr2 Ano4 Ano7 Atp2c2 Clca2 Atp2c1 Psma2 Stoml3 Mcoln2 Atp12a Mcoln3 Psmd2 Atp13a5 Trpv1 Atp13a4 Atp13a2 Trpc5 Trpm6 Ttyh1 Trpm3 Ttyh2 Psmc2 Trpm8 LOC100361584 Trpm5 Atp8a2 Atp1a4 Trpc3 Atp4b Psmd1 Trpc7 Atp4a Psmd7 Trpm1 Bsnd Trpc4 Mcoln1 Atp1a1 Atp1a2 Trpc6 Psmd3 Trpv3 Atp13a1 Atp1a3 Psmd6 Trpa1 Slc6a11 Slc6a13 Slc6a1 Slc6a12 Raf1 Abcd1 Furin Slc22a5 Derl1 Prkar1b Prkar1a Bmp1 Fbxl5 Skp1 Slc21a4 Apobr Vldlr Apoc1 LOC100910181 Apoc4 Kcnj11 Abcc9 Prkar2b Prkar2a Os9 Erlec1 Slc5a8 Hba1 Slc25a22 Slc17a5 Rab11a Slc17a6 Slc17a7 Slc17a8 LOC100911440 Slc25a18 LOC287167 Slc5a5 Sel1l Slc7a3 Slc7a2 Slc7a1 Slco4a1 Slc4a7 Slc4a9 Slc2a9 Slc11a2 Slc7a8 Slc7a9 Sri Fgf21 Slc50a1 Slc7a5 Slc7a6 Slc7a7 Angptl4 Slc6a2 LOC100361444 Heph Lmf1 Slc14a1 Lmf2 Slc18a1 Slc7a10 Slc30a10 Slc4a4 Slc4a3 Slc22a15 Slc6a7 Slc46a1 Slc4a8 Slc6a9 Slc2a12 Slc2a10 Slc6a6 Slc6a5 Slc12a4 Slc39a2 Slc12a2 Slc39a3 Slc12a1 Slc39a4 Slc39a6 Slc8b1 Slc38a3 Slc38a2 Slc38a5 Slc38a4 Slc22a6 Slc8a3 Slc12a5 Slc22a3 Slc3a1 LOC100911874 RGD1559971 Cand1 Slc25a29 Slc43a2 Slc43a1 Slc22a7 Vegp2 Slc39a7 Slc39a8 Slc12a6 Slc12a7 Slc47a1 Slc8a2 Slc8a1 RGD1304770 Slc5a6 Pdzd11 Slc1a3 Slc1a5 Slc1a4 Slc15a1 Slc1a7 Slc1a6 Lcn1 Slc1a1 Slc5a4 Slc5a2 Scarb1 Slc9a1 Cubn Amn Hdlbp Apoa1 Vps25 Slc24a4 Slc24a2 Slc20a2 Slc10a6 Ahcyl2 Slc35d1 Slco3a1 Slc45a3 Slc2a6 Slc2a4 Lcn12 Slc5a10 Slc4a2 Slc4a5 Slc4a1 Slc7a11 Slc13a4 Slc41a1 Slc41a2 Slc40a1 Slc24a5 Slc13a1 Slc13a2 Slc26a2 Slc13a3 Slc26a1 Slco1c1 Lcn9 Slc5a9 Slc5a7 Slc20a1 Slc4a10 Cyb5r1 Slc15a3 Slc27a1 Pmpcb Slco1a1 Pmpca Slc35b2 MGC94335 Afg3l2 Rhag Micu3 Slc44a4 Stoml2 Micu2 Slco1a4 Slc35b3 Slco1a2 LOC100910779 Micu1 Slc44a5 Yme1l1 Spg7 Slc44a3 Phb2 Rhcg Slco1b2 LOC688708 Slc25a10 Slc30a5 Nipal1 Tusc3 Slc16a10 Slc30a6 Mrs2 Slc30a8 Nipal4 Pqlc2 Slc27a6 Gpihbp1 Slc39a14 Ankh G6pc Lrrc8e Slc9a4 Lrrc8c Slc9a5 Lrrc8b Slco2b1 Lrrc8a Slc31a1 Azgp1 Slc26a7 Dmtn Slc26a9 Pip Slc26a6 Slc30a1 Slc27a4 Slc26a3 Slc36a2 Slc33a1 Slc34a1 Slc35a2 Slc16a2 Slc34a3 Slc32a1 Slc38a1 Add1 Slc6a15 Nipa1 Slc6a14 Add2 Atp6ap1 Slc6a19 Ctns Slc6a18 Nipa2 Slc35b4 Add3 Slc36a4 Nipal2 Slc6a20 Nipal3 Slc36a1 Slco1a6 Slc35d2 Slco2a1 Apod Slc2a1 Slc9a2 LOC100362065 Slc9a9 RGD1561777 Ccdc109b Slc9a3 Mcu Slc9a6 Cp Slc9a8 Slc9a7 Atp6v1d Psmc6 Eif2s3 Psmb10 Ftl1 Psmb8 Psmb9 Psmb4 Psmb11 Psmb5 Psmf1 Psmb6 Magt1 Psmd4 Psmb2 Psmd5 Psmd8 Psmd9 Psmb3 Psma8 Psmd11 Psmd12 Slc16a3 Eif2s1 Slc16a7 Eif2s2 Psmd13 Slc16a8 Psmd14 Slc16a1 Ap2a2 Slc28a2 Slc28a1 Slc28a3 Slc29a3 Atp8a1 Slc29a2 Slc29a4 LOC100911721 Slc29a1 LOC691960 Psmc3 Trpm2 Atp6v0c Slco4c1 RGD1561661 Cltc Clta Ap2s1 Ap2a1 Ap2m1 Pcsk9 Gnb3 Gnb5 Gnb2 Gnb1 Gng13 Gng12 Gng11 Prkaca Prkacb Ano6 LOC100912034 Gnb4 Gng4 Gngt2 Gng5 Gngt1 Gng8 Gng3 Slc11a1 Vcp Ldlr Tfrc Tf Avp Hmox1 Ireb2 Aco1 Ftmt Tfr2 Hfe Abcg2 Slc44a2 Abcg3l3 Abcg3l1 Steap2 Cybrd1 Cyb5r2 Cyb5rl Runx1 Tcirg1 Hmox2 LOC100360087 Npc1 Slc35a1 Nceh1 Lipa Mylip Mb Soat1 Soat2 Sgk1 Atp11a Psmc5 Psma1 Slc2a8 Psma4 Psmc1 Lpl Psma3 Psmc4 Psma6 Psme1 Psme2 Pcsk6 Ldlrap1 Pcsk5 INTERLEUKIN-1 PROCESSING%REACTOME%R-RNO-448706.1 Interleukin-1 processing Nfkb2 Nfkb1 Il1b Il18 Casp1 Il1a Rela FC EPSILON RECEPTOR (FCERI) SIGNALING%REACTOME DATABASE ID RELEASE 66%10145167 Fc epsilon receptor (FCERI) signaling Psmc6 Psmb10 Psmb8 Psmb9 Psmb4 Psmb11 Psmb5 Psmf1 Psmb6 Rac1 Psmd4 Psmb2 Psmd5 Psmd8 Psmd9 Psmb3 Psma8 Psmd11 Psmd12 Psmd13 Psmd14 Psmc3 Ube2n Bcl10 Ube2d1 Jun Skp1 Ppp3r1 Nfkb1 Mapk9 Mapk8 Fos Fbxw11 Chuk Btrc Mapk1 LOC100362142 Tab2 Tab3 Lyn LOC100912618 Ube2v1 Ikbkb Syk Mapk10 Map2k7 Map2k4 LOC100912399 Map3k1 Traf6 Cul1 Cdc34 Tab1 Rela Map3k7 Lat2 Prkcq Pak2 Nfkbia LOC100910771 Pak1 Kras G6pc Pik3r1 Pik3r2 Psmb7 Psmb1 Vav2 Vav1 Psma5 Vav3 Pdpk1 Psma2 RGD1560225 Psmc5 Pik3cb Psma1 Psmd2 Ppp3ca Psma4 Nfatc2 Tec Psmc1 Psma3 Txk Psmc4 Psma6 Psmc2 Lat Plcg1 Psme1 Psmd1 Hras Psme2 Psmd7 Nras Sos1 Nfatc3 Lcp2 Psmd3 Shc1 Psmd6 Grb2 Itk SEROTONIN RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145563 Serotonin receptors Htr7 Htr5a Htr4 Htr2c Htr2a Htr1d Htr1f Htr1a Htr6 Htr1b Htr2b REVERSAL OF ALKYLATION DAMAGE BY DNA DIOXYGENASES%REACTOME DATABASE ID RELEASE 66%10146230 Reversal of alkylation damage by DNA dioxygenases Fto Alkbh5 PROTEIN-PROTEIN INTERACTIONS AT SYNAPSES%REACTOME%R-RNO-6794362.1 Protein-protein interactions at synapses Dlgap2 Grin2d Dlgap3 Grin2b Dlgap4 Grin1 Epb4.1l5 Grm1 Lrrtm2 Lrrtm3 Lrrtm4 LRRTM1 Dlg1 Dlg2 Dlg3 Dlgap1 Lrrc4b Ppfia1 Ppfia2 Ppfia3 Lrfn2 Ppfia4 Lrfn3 Lrfn1 Lrfn4 Ptprd Slitrk6 Slitrk5 Slitrk3 Slitrk2 Slitrk1 Ppfibp1 Il1rap Ppfibp2 Ptprf Epb4.1 Nrxn2 Shank1 Shank2 Nlgn1 Homer3 Nlgn2 Nlgn3 Homer2 Homer1 Epb41l2 Epb41l3 Il1rapl1 Gria3 Gria4 Flot1 Flot2 Rtn3 Dbnl Ntrk3 Dlg4 MET PROMOTES CELL MOTILITY%REACTOME DATABASE ID RELEASE 66%10146247 MET promotes cell motility Gab1 Src Crk Rap1a Itga3 Dock7 Rac1 Hgf Lama4 Lamc1 Lamc2 Lamb1 Crkl Ptk2 Lamb2 Lama1 Tns4 Rapgef1 Lamb3 Grb2 LOC100911248 MRNA EDITING: C TO U CONVERSION%REACTOME%R-RNO-72200.1 mRNA Editing: C to U Conversion Apobec1 Apobec2 A1cf Apobec4 ECM PROTEOGLYCANS%REACTOME%R-RNO-3000178.1 ECM proteoglycans Ncan Agrn Itgb6 Sparc Dcn Comp LOC102550316 Tnn Serpine1 Vtn Itga8 Itga7 Acan Tnr Vcan Bcan Col9a1 Col9a2 Col9a3 Dspp Dmp1 LOC100910284 Hapln1 Matn4 Itga2b Matn1 Dag1 Itgax P38MAPK EVENTS%REACTOME DATABASE ID RELEASE 66%10145201 p38MAPK events Ralgds Kras Hras Nras Mapk14 Mapkapk3 Mapk11 Mapkapk2 INNATE IMMUNE SYSTEM%REACTOME%R-RNO-168249.1 Innate Immune System Myo1c Ppie Actb Pld4 Ube2n Atox1 Tlr7 Tlr8 Irak4 Myo10 Eea1 Nlrp4 Map2k7 Dtx4 Ripk2 Tbk1 Map2k6 Ddx41 Ager Nlrp4a Dusp3 Irf3 Map2k4 Trim21 Map3k8 Trim32 Dusp4 Peli3 Nfkbib LOC100912399 Peli2 Map3k1 Traf6 Cul1 Vrk3 Commd9 Rps6ka2 Rps6ka1 Pdxk App Cd53 Atg7 Rps6ka3 Xrcc6 Rps6ka5 Bpi Tirap Hbb-b1 LOC100912585 Xrcc5 Tab1 Dusp7 Dusp6 Rela Atf1 Atf2 Map3k7 Peli1 Irak2 Cd59 Np4 Ctsa Ptprc Cyfip1 Serpinb3a Cd63 Pnp Sdcbp RGD1304587 Cct2 Apaf1 LOC100909857 Ddost LOC498300 Vamp8 Defa7 Gdi2 Anpep Plaur Nfkbia Serpinb12 LOC100910771 Cct8 Defa5 Cst3 Dnajc13 Nckap1l Serpinb10 LOC100909879 Ilf2 Qsox1 Mpo Fcgr3a C1s LOC685953 C1r Slc2a5 Cd36 Masp2 C1qb Ctsc Rock1 Colec10 Rap2b C4a Syngr1 C1qa Tmem179b C4b Svip Serpinb1b Ctsz Mlec LOC100909666 Arg1 Gzmm Frk LOC102549354 Serpinb1a C2 Cstb Psmb7 Psmb1 Vapa Lrrc7 Prdx4 Gmfg C5ar1 Nme2 LOC687609 Dsn1 Lrmp Rap2c Grn Stom Dsp Cab39 Cd14 LOC100909700 Atp6v0a1 Ltf Psma5 Slpi Padi2 Plekho2 Rap1a Fcer1g Tollip Gsn Pkp1 Chi3l1 Psma2 Pglyrp1 Snap29 Psmd2 Commd3 Idh1 Bst1 Ptpn6 Psmc2 Fgl2 Tnfaip6 Psmd1 Psmd7 Iqgap1 Prdx6 Tspan14 Psmd3 Psmd6 Colec11 Lbp Ptpn4 Jun Ppp2cb Ppp2ca Skp1 Ppp2r1a Nfkb2 Nfkb1 Mapk9 Mapk8 Fos S100b Mapk7 Dhx9 Fbxw11 Chuk Ppp2r1b Ecsit Mapkapk3 Btrc Mapkapk2 Mapk1 Nkiras1 LOC100362142 Nod1 Nod2 Nkiras2 Creb1 Tab2 Tab3 LOC100912618 Ube2v1 Ikbkb Mapk14 Myd88 Tnip2 Mapk11 Mapk10 Hsp90b1 RGD1560225 Ppp3ca Nfatc2 Tec Txk Lat Plcg1 Nfatc3 Lcp2 Itk Cnpy3 Unc93b1 Tlr3 Ddx3x Plac8 RGD1563818 Cotl1 Cmtm6 RT1-A2 Lpcat1 RT1-A1 Ggh Clec5a B2m LOC100125364 Glipr1 Rnaset2 Gpr84 RGD1561778 Ist1 Cpped1 Cand1 A1bg Clec4d Pdzd11 Crk Atp6v1d Cda Lamp1 Ftl1 Psap RatNP-3b Svs1 Fuca2 Serpinb6b Igf2r Lrg1 RGD1306474 Magt1 Rac1 Acly Cap1 Pdap1 Bpifb2 Doxl2 Doxl1 Cpne3 Rnase17 Rab27a Psmd11 Psmd12 Fabp5 Dynlt1 Psmd13 Psmd14 Tmem30a Lamp2 Unc13d Mif Ap2a2 Crisp3 Cfp S100a11 Aga Cfd RT1-M3-1 Serpinb3 Atp8a1 Kcmf1 Aldh3b1 Ndufc2 Serpinb6 Aprt Faf2 Cpne1 Psmc3 Diaph1 Trpm2 LOC100364500 Defa11 Fcnb Defa10 RT1-S3 Cant1 Bcl10 Tmem173 Cxcr2 Atp6v0c RGD1564463 Anxa2 Rbsn Mgst1 Retn RT1-CE2 Dpp7 Nit2 Src RT1-CE3 RT1-CE4 RT1-CE7 RT1-CE5 Slco4c1 Hsp90ab1 RGD1561661 Rab3a Copb1 Cat Cd177 RT1-CE10 Hebp2 Rab7a Ptges2 Ptafr Tubb5 Creg1 Pigr Mettl7a Alox5 Kcnab2 Ppp3r1 Pygb Rab4b Bcl2 Ticam2 Mme Neu1 Lta4h Ms4a3 Cxcl2 Cxcl1 Epx S100a8 Cd68 Rab5b Cxcl3 Rab5c Chit1 Ampd3 Capza2 Slc27a2 Dgat1 Rab6a LOC683761 LOC100364956 Atp6ap2 Tmem63a Ptprn2 Nhlrc3 Naprt1 Ano6 Pa2g4 Gm2a Dbnl Fcgr2b LOC103693683 Atad3a Serpina3m Rab9b Fcgr2a Trappc1 Tlr2 Plau Slc11a1 Kpnb1 Chrnb4 Fpr1 Arl8a Pld1 Ostf1 Ear1 Vcl Prg3 Erp44 Stk10 Sptan1 Vcp Prg2 Rab18 Cd300lb Siglec15 Ghdc LOC100910990 Slpil3 Rab10 Cd300e Rab14 Slpil2 Cdc34 Vnn1 Rab24 Actr10 Nbeal2 Lamtor3 RT1-A Arsa Tmbim1 Tnfaip3 Dok3 Dync1h1 P2rx1 Acaa1a Acaa1b Lamtor2 Lamtor1 Apeh Ypel5 Dync1li1 Slc44a2 LOC103692716 Qpct RGD1565355 Cybb Cyba LOC361635 Actr1b RT1-M2 Hmha1 Lgals3 RT1-M5 RT1-M4 Nfam1 Ubr4 Crispld2 Pycard Crebbp Stk11ip Rab3d Rbm12 Galns Gca C3ar1 Prkcd Armc8 Olfm4 Fcar Kras Gstp1 Asah1 Pik3r1 Mnda Pik3r2 Bri3 Ptx3 Srp14 Tcirg1 Hmox2 Ptprj Jup Mospd2 Impdh1 Ddx58 Impdh2 Ap1m1 Nfasc Rnase3 LOC100360575 Rnase2 Enpp4 Sirpa Tyrobp LOC100360087 Cdk13 LOC299277 Golga7 Hvcn1 Stbd1 Dsg1 Txndc5 Dnajc5 Csnk2b Actr2 Fgr Alad Gla Dnajc3 Tnfrsf1b Arhgap9 RGD1559482 C3 RT1-M6-1 Lair1 Ppbp Atp11a Vat1 Pik3cb Uba3 Aoc1 RT1-M6-2 Map3k14 Agpat2 Ptpn11 Relb Rhoa Eef2 Arpc5 Gsdmd Prcp Hras Cyb5r3 Nras Rhof Sos1 Rhog Ckap4 Tbc1d10c Degs1 Shc1 Grb2 Tom1 RGD1308751 Nos3 Mavs Atp6v1g1 Bpifa2 Atp6v1g2 Rnase6 Bpifa1 Atp6v0a4 Atp6v1b2 Fyn Atp6v0a2 Atp6v1h Atp6v1f LOC497963 Stat6 Bpifb4 Pglyrp3b Pglyrp3 Bpifb6 Pglyrp4 Pglyrp2 Itln1 Eppin Bpifa2f Chga Bpifa5 Reg3g Elane Adam8 Ube2d1 LOC103690254 Try10 LOC100365995 Atp6v0d1 Atp6v1c2 Atp6v0d2 Timp2 Atp6v1a Atp6v0e2 Atp6v0e1 Atp6v1g3 Atp6v1e1 Atp6v1e2 Atp6v1c1 Nos1 MGC114246 Capn1 Testin Lyn Yes1 Hck Ceacam10 Syk Mmp8 Itgam Mmp9 Try4 Itgb2 Vtn Atp7a Ceacam1 Prkcq Tlr4 Prss2 Ikbke Tank Traf3 LOC100364523 Apob Itgal Itgax Prss1 Ctsd Ctsb Trem2 Ctsg Ctsl Ctsm Ctsj RGD1564657 Vav2 Ctsk Vav1 Ctsq Ctsr LOC100909977 LOC102554637 Vav3 Cts8 Cts7 RGD1564827 Icam2 Pla2g6 Raf1 Psen1 Ncstn LOC364561 Pin1 LOC683849 Cd47 Cts8l1 Ttr Il1b F2 Mre11a Cpb2 Txn1 Lgmn Lat2 Trem1 Ube2m Myo9b Abi1 Abi2 Potef Panx1 Myh9 Nck1 Sugt1 Txnip Mefv Pstpip1 P2rx7 Arpc1b LOC100909750 Ncf1 Ncf4 Ptk2 Actg1 Cyfip2 Nckap1 Defb26 Defb28 Ccr6 Hexb Defb30 Defb18 LOC100909609 Defb36 Defb14 Pld2 Defb12 Defb29 Defb49 Defb25 Defb43 Defb44 Tax1bp1 Art1 Defb13 Defb41 Defb1 Defb22 Defb23 Defb20 Defb21 Fcgr1a Cd247 Pkm Nlrp3 Pgam1 Glb1 Dock1 Elmo2 Klrc2 Manba Aldoa Gyg1 Aldoc Cpn1 Cpn2 Cr2 Clu C5ar2 Cd46 Serping1 Brk1 C6 Pfkl Pgm2 Cfhr1 Cd19 Pgm1 C8g Baiap2 RGD1564614 Cd81 C8a B4galt1 C8b Limk1 Nf2 Pak2 Pak3 Cfh Pak1 Wasl Aldoart2 Abl1 Wasf1 Arpc4 G6pc Agl Arpc3 Pla2g2a Gpi Nckipsd LOC100361457 Cd209b Cd209e Clec4m Actr3 Was Mapk13 Cd209a Mapk12 Pik3c3 Arsb Pik3r4 Pdpk1 Dhx36 Cdc42 LOC100911597 Dera Gusb Hpse Man2b1 Wipf1 Wipf2 Wipf3 Cd44 Psmc6 Psmb10 Gaa Psmb8 Psmb9 Psmb4 Psmb11 Pygl Psmb5 Psmf1 Psmb6 Psmd4 Psmb2 Psmd5 Psmd8 Psmd9 Psmb3 Psma8 Ppapdc1a Pld3 Ppapdc1b Prkaca Prkacb Tlr9 Cd4 Birc3 Birc2 Aim2 Cyld Tlr6 Tlr10 Casp4 Casp1 Casp2 Nlrp1a Casp8 Casp9 Psmc5 Cd3g Psma1 Psma4 Psmc1 Psma3 Psmc4 Psma6 Psme1 Psme2 TRANSMISSION ACROSS ELECTRICAL SYNAPSES%REACTOME DATABASE ID RELEASE 66%10145508 Transmission across Electrical Synapses Gja10 Panx1 Gjd2 Gjc1 EPHA-MEDIATED GROWTH CONE COLLAPSE%REACTOME DATABASE ID RELEASE 66%10146028 EPHA-mediated growth cone collapse Src Fyn Rhoa LOC100912512 Lyn Yes1 Ngef IRF3 MEDIATED ACTIVATION OF TYPE 1 IFN%REACTOME%R-RNO-1606341.1 IRF3 mediated activation of type 1 IFN Irf3 HDL REMODELING%REACTOME DATABASE ID RELEASE 66%10145453 HDL remodeling Apoa1 Apoc2 Apoe Abcg1 Lcat Lipg Pltp SIGNALING BY GPCR%REACTOME DATABASE ID RELEASE 66%10144870 Signaling by GPCR Plcb1 Plcb3 Ffar1 Gnaq Gna11 Gna14 Gna15 Plcb4 Gnai3 Akt1 Gnao1 Chrm4 Gnat2 Gnaz Rhob Rhoc Rps6ka2 Rps6ka1 App Rps6ka3 LOC100912585 Rock1 C5ar1 Tshb Gnal Gnat3 Grp Ppp2cb Ffar4 Ppp2ca Ppp2r1a Mapk7 Ppp2r1b Mapk1 Adora3 Creb1 Adora2a Adora2b LOC100911796 LOC100363178 Adora1 LOC100365814 Lrp1 Gpr39 Olr663 Olr660 Olr561 Olr1024 Olr560 LOC100910009 Olr158 Cnga1 Olr557 LOC100910335 Gucy2f Pde6b Olr164 Rcvrn Olr659 Olr160 Gucy2d Pde6a Olr657 Rgs9 Olr662 RGD1560341 Olr664 Olr1868 Olr1199 Gpr27 Olr653 LOC100910402 Olr651 Olr650 Olr294 LOC100911909 Olr544 Olr1197 Olr1196 Olr1195 Olr1194 Olr1198 LOC100910409 Olr1128 LOC100911893 LOC100910928 Olr323 Olr119 Olr1126 LOC100912097 Olr1125 Olr420 Olr217 Olr1121 Olr1122 Olr1129 Olr322 Olr214 Gpr84 Olr215 Olr414 Guca1b Ppef1 Olr1512 Kng1l1 Metap2 Olr1513 Metap1 Olr416 Olr556 Gnat1 Nmt1 Gpr150 Olr1511 Guca1a Cngb1 Olr413 Olr1517 Rgs9bp Olr319 Fnta Olr120 Nmt2 Olr321 Sag Olr1514 Grk4 LOC100911380 Grk1 Fntb Olr417 Olr418 Pde6g LOC100910041 Olr259 Olr1163 Olr1166 LOC684208 Olr127 Olr530 Olr126 Olr931 Olr674 Olr129 Olr532 Olr1174 Olr670 Gpr45 Olr675 Olr892 Olr247 Olr1156 Olr190 Olr194 Olr267 LOC500460 Olr192 Olr262 Olr1064 Olr896 Olr263 LOC100910049 Olr698 Olr799 LOC103693566 Olr922 Olr684 Olr1186 LOC100910120 Olr536 Olr1185 Olr143 Olr535 Olr140 Olr142 Olr148 LOC100910648 Olr1016 Olr149 Olr951 Gpr25 LOC100910224 Olr666 Olr1179 Olr522 Olr130 Olr527 Olr526 LOC100910637 Olr132 LOC100910010 Olr529 Olr528 Olr139 Olr137 Olr686 Olr1877 LOC100910559 Olr186 Olr189 Olr1081 Olr1147 Olr188 Olr584 Olr1082 Olr281 Olr382 Olr384 Olr1086 Olr1087 Olr587 Olr581 Olr282 Olr776 Olr582 Olr777 Olr583 Olr283 Olr962 Gpr15 Olr964 Olr285 Olr286 Olr1135 Olr1132 Olr172 LOC100910051 Olr1130 Olr170 Olr198 Olr588 Olr199 Olr1155 Olr597 Olr1057 Olr196 LOC100911805 Grk6 Olr252 Olr1052 Olr598 Olr695 Olr251 Olr250 Olr697 LOC100910999 Olr590 Grk5 LOC100910445 Olr1143 Olr180 Olr690 Olr1144 Olr783 Olr379 Olr1142 LOC100910162 Olr782 Gpr176 LOC100911839 Olr184 Olr845 LOC100910274 Olr847 Olr848 Olr1391 Gpihbp1 Olr852 Olr1496 LOC686792 LOC100912204 Olr1096 LOC100365798 RGD1562066 Olr844 Olr841 Olr744 Olr745 LOC100909686 Olr878 LOC100910597 Olr1376 Penk Olr850 Olr851 LOC100909578 LOC100909683 LOC100910294 Kng1 LOC687097 LOC100909884 LOC100909885 Olr1374 Olr1372 Olr1373 Olr1370 Kng2 Olr1071 Olr569 Olr174 Olr175 Olr774 Olr176 Htr4 Olr1274 Olr1076 LOC100910876 Olr575 Olr1075 Olr373 Olr1275 Olr1070 Olr1137 Htr7 Olr375 Olr377 Olr378 Olr372 Olr1079 Olr374 Olr1073 Olr854 Olr853 Olr279 LOC100911035 Olr765 Olr278 Olr376 Htr6 LOC100910256 Npff Npffr2 Olr834 Olr641 RGD1560028 LOC100909438 Psap Hcrt LOC100909796 Npffr1 Gpr83 Qrfp LOC690821 LOC100912217 LOC100909783 Olr601 Olr602 Olr604 Olr709 Olr609 Olr607 Olr608 LOC687088 Olfr873 Olr806 LOC686677 Olr702 Olr808 Olr705 Olr704 Olr807 Olr519 Oxgr1 Olr614 Olr718 Olr811 Ccr1 Olr514 Ccr1l1 Olr515 Ptgdr2 Olr611 Sucnr1 Olr610 Olr819 Olr716 Olr713 Olr816 Olr717 Olr714 Olr813 Olr812 Olr1382 Olr1381 Olr1384 Olr1383 Olr711 LOC100912327 Olr818 Olr712 Olr724 Olr1380 Reep6 LOC684683 Olr720 Olr722 LOC686660 Olr1385 Hcrtr1 Olr1378 Qrfpr Reep1 Cxcr2 Reep5 Hcrtr2 Olr729 Reep4 Reep3 Reep2 Olr725 Ptafr Gpr31 Cxcl2 Rgr Cxcl1 Gpr18 Gpr55 Gpsm3 Htr5a Gpsm2 Cxcl3 Gpsm1 Cnr2 Ccl4 Opn3 Cnr1 Htr1d Htr1f Htr1a Htr1b Hrh4 Ptger3 Gpr183 Mtnr1a Opn5 Pcp2 Hcar1 Hcar2 LOC687065 Drd5 Drd1 LOC684539 Drd4 Drd2 Olr820 Olr821 Olr823 Fpr1 Mgll Abhd12 Daglb Abhd6 Dagla C3ar1 Prkcd Kras Pik3r1 Pik3r2 Adra2a Gnai2 Adra2c Rbp4 C3 Lrp10 Rbp2 Ppbp Tex12 Rbp1 Lrp8 Apom Lrp12 Rhoa Lpl Bco1 Rdh11 Lrat Hras Nras Bco2 Sos1 Gnai1 Grb2 Olr1442 Olr1443 Olr1548 Olr80 Olr1440 Olr1547 Ppp1ca Pde4a Egfr Hbegf Pde4d Pde4c Ppp1r1b Ghrl Cdk5 Olr1436 Ptgir Olr1569 Olr1567 Olr1421 Olr1568 Olr1565 Olr1566 Olr1538 LOC100912374 Olr1539 Olr1437 Olr1439 Olr1433 Olr1434 Olr1435 LOC103690304 Olr83 LOC100912370 Olr1533 Olr1432 Olr1535 Olr1537 Olr1536 Olr81 Olr1449 Olr1542 Olr1541 Olr1540 Olr1445 LOC103693022 LOC100912463 Pnlip Clps Abca4 Prkca Oprl1 Tas2r144 Ccl21 Grm3 Casr Prokr2 Mc3r Grm1 Ccr5 Grm6 Gal Tas2r113 Ccr4 Grm2 Ccr3 Grm8 Gpr37 Ccl27 Cckar Tas2r114 Gper1 Tas2r110 Ccl20 Uts2r Prokr1 Ccl25 NMS Gprc6a Tas2r124 Xcr1 Tas2r125 Cxcl16 Tas2r126 Pdyn Prlhr Tas2r121 Ccr10 Tas2r103 Gpr37l1 Tas2r104 Ccl19 Tas2r123 Ccr7 Tas2r116 Ccr8 Tas2r140 Cxcr3 Tas2r120 Tas2r102 Cxcl10 Ccr9 Tas2r145 Cxcl11 Tas2r119 Ece2 Tas2r118 Ece1 Tas2r117 Xk Pde1b Sstr5 Brs3 Tas2r107 Tas2r108 Npbwr1 Tas2r105 Pyy Pnoc Tas2r106 Tas2r129 Ccl5 Npy2r Tas2r109 Mc4r Prkcq Tas2r136 Prok2 Tas2r137 Tas1r1 Oprm1 Prok1 Tas2r135 Mchr1 Sstr1 Tas2r13 Aplnr Tas2r130 Tas1r3 Sstr4 Tas2r139 Sstr2 Cck Npy1r Apln Tacr3 Apob Tacr2 Bdkrb1 Apoc2 Apoe Bdkrb2 Rln3 Apoa2 Npb Ppy Trh Ccl1 Npw Mc2r Npy Gng10 Nps Arhgef6 Arhgef5 Pde3a Arhgef39 Arhgef7 Arhgef37 Arhgef38 Arhgef33 Prex1 Adra1a Tbxa2r Itsn1 Arhgef2 LOC102556447 Arhgef4 Arhgef3 Plekhg5 Sstr3 Arhgef19 Arhgef18 Plekhg2 Kalrn Adra1d Plxnb1 LOC100912512 Gna12 Vav2 Gna13 Pde2a Vav1 Arhgef11 Cyct Akap13 Arhgef16 Pde10a Arhgef15 Pde11a Gphb5 Net1 Gnrhr Ect2 Gpha2 Arhgef26 Fgd2 Gnrh1 Mcf2l Tiam1 Fshr Tiam2 Vav3 Tshr Fgd3 Sos2 Ngef Cxcr5 Uts2b Npy5r Nmur2 Cxcr6 Oprd1 Trpc3 Trpc7 Lhcgr LOC100909513 Trpc6 LOC100360745 Olr1600 Olr1605 Olr1405 Olr1601 Olr1407 Olr1404 Olr1406 LOC100910837 Olr1368 Olr1369 Olr226 LOC100911348 Olr229 Olr227 Olr1602 LOC684170 LOC103692138 Olr1504 Lhb Olr233 Olr428 Olr232 Olr427 Olr1505 Olr234 LOC100911377 Olr1400 LOC100911376 Olr231 Ptgdr Olr425 Olr1501 Olr230 Olr208 Olr1202 Awat2 Adcy8 Olr244 LOC103693685 Adcy9 Olr1519 Adcy5 Olr203 Adcy4 Olr411 Adcy7 Olr209 Adcy6 Prkar1b Olr1007 Prkar1a Olr1006 LOC100911223 Ttr Olr237 Olr434 Olr1306 Olr442 Olr441 Olr113 Olr210 Olr1520 Olr114 Olr1523 Olr218 Olr1522 Olr1521 F2rl3 Olr206 F2r Olr1118 Olr204 F2 Olr205 RGD1564865 LOC100911398 Ptger2 Olr1115 Cga F2rl2 Olr1117 Hebp1 Uts2 Pde7a Pik3r5 Fpr-rs6 Ntsr2 Olr1734 Olr1340 Trhr Olr485 Nmu Fpr-rs3 Pf4 Olr486 Olr16 Mc5r Fpr2 Ntsr1 Olr1735 Fpr3 Pik3r3 LOC100911043 Pmch Anxa1 Pik3r6 Olr1737 Rxfp1 Olr14 Rxfp2 Olr1736 Kel Fpr-rs4 Insl3 Olr488 Tac3 Olr484 Pde7b Kiss1 Olr1730 Rxfp3 LOC100912515 Tac1 Edn2 Olr1627 Olr491 Ednra Ednrb Olr1626 Edn3 Olr490 Grpr Olr1621 Cx3cr1 LOC100912408 Edn1 Olr1625 F2rl1 Olr1624 Olr200 Sst Olr339 Ackr4 Olr1345 Ackr3 Olr338 Nmb Olr1343 Xcl1 Cxcl9 Olr202 Olr1344 Cxcl6 Olr1341 Cx3cl1 Olr1356 Taar9 LOC100912605 LOC100911849 Hrh2 Fshb LOC100910199 Taar6 Agt Olr346 Taar5 Taar2 Olr1214 Olr450 Olr499 Olr496 LOC100912505 Olr493 Olr1606 Akt3 Olr1607 Olr1749 Agtr2 Prlh Olr1608 Olr1362 Galr1 Ccrl2 Olr459 Nts Olr458 Olr1361 Oprk1 Olr1366 Olr1364 Olr360 Olr462 Olr1611 Olr1610 Olr1358 Olr1612 Olr20 Olr24 Olr23 Olr1456 LOC100912431 Olr1597 Olr1593 Olr1592 Olr1450 Olr1452 Olr1598 Olr1454 LOC100909966 LOC100365887 LOC100912159 Olr1654 LOC103693822 Olr30 Olr32 Pla2g4a Olr34 Olr331 Olr332 Olr1643 Olr334 Olr330 Olr1642 Olr1644 Olr1645 Olr473 Olr470 Olr1744 Olr1641 Olr1743 Olr1746 Olr472 Olr1640 Pde8b Olr477 Olr475 Pde8a LOC100911479 Olr1235 Olr1738 LOC103690286 Olr1231 Olr329 Or7e24 LOC103690280 Olr326 Olr325 Olr1339 Olr1639 Olr13 Olr12 Olr1637 Olr1638 Olr340 Olr341 LOC102555599 Olr1635 Gabbr1 Olr1630 Olr1631 Gabbr2 Olr1632 Olr1633 Olr1423 Olr1560 Olr63 LOC100912684 Olr1424 Olr1564 Olr1425 Olr1422 Olr1558 Olr1559 LOC684179 Olr1555 Ptgdrl Olr67 Olr68 Olr69 Olr1416 Cxcl12 Olr70 Olr1418 Olr1417 Olr1551 Adcy3 Prkar2b Olr1557 Prkar2a Olr1553 LOC686967 Olr77 LOC100909611 Olr1693 Rtp4 Olr74 Cxcr4 RGD1562400 Olr78 Olr75 Olr1583 Olr1589 Olr1488 LOC100912420 Olr1582 LOC100909993 Rtp3 Rtp2 Olr1475 Olr1470 LOC687110 Olr1576 Olr49 Olr46 Olr1588 Olr48 Arrb1 Olr1467 Olr1468 Olr1469 Olr50 Arrb2 Olr51 Olr59 Olr1671 Olr1471 Olr1667 Olr29 LOC100909831 Adrbk1 Olr27 Olr25 Cyp4v3 Olr1462 LOC100912540 LOC100911586 Rock2 Stra6 Rdh10 Rdh16 LOC100365958 LOC100362350 Akr1c12l1 Cmklr1 Gpr35 Akr1c19 Akr1c13 Akr1c14 Akr1c12 Ccr6 Pomc Apoa1 Oxtr Oxt Rpe65 LOC100909648 Avpr1b Dhrs9 Pik3cg Avpr1a Myo7a Sdr9c7 Hsd17b6 Gpc6 Gpc4 Gpc2 Gpc1 Opn1sw Dhrs3 Rlbp1 Akr1b7 Akr1b8 Opn1mw Ghrh Ramp3 Vipr2 Sct C5ar2 Gip Gipr Akr1c2 Pth1r Iapp Crhr2 Akr1c3 Gcgr Adgre1 Crhr1 Glp2r Pth2 Ramp2 Ghrhr Akr1c1 Agrn Pdpk1 Sdc2 Sdc3 Sdc4 Adra2b Adrb3 Pth Sctr Adm Crhbp Calcb Vip Calca Ramp1 Htr2c Htr2a Adcyap1r1 Ucn Dgkk Adcyap1 Dgki Ucn2 Pth2r Adm2 Htr2b Crh Lpar5 S1pr1 S1pr5 S1pr4 S1pr3 Lpar1 Lpar3 Lpar2 S1pr2 Ccl9 Ccl6 Dgkg Gpr4 Dgkd Dgke Dgka Dgkb Gpr132 Gnb3 Gpr143 Gnb5 Rgs3 Lppr1 Gnb2 Opn4 Rgs19 Gnb1 Lppr4 Rgs2 Lppr5 Gng13 Rgs18 Lppr2 Gng12 Lppr3 Hrh1 Gng11 Prkaca Chrm1 Prkacb Chrm5 Ghsr Itpr1 Arhgef25 Dgkz LOC100909523 Itpr3 LOC100912034 Dgkq Gnb4 Dgkh Cysltr2 Glp1r Camk4 Gcg Cysltr1 Gng4 Gpr65 Gngt2 Gpr68 Ptgfr Gng5 Gngt1 Prkch Ptger1 Gng8 Gng3 Chrm3 Agtr1b Agtr1a Chrm2 Ltb4r Ffar2 Ffar3 Ltb4r2 Avp Pde3b Akt2 P2ry6 Lpar6 P2ry4 P2ry1 Gpr17 Lpar4 P2ry12 P2ry2 P2ry10 P2ry13 Cckbr Gast Adrb2 Tacr1 ELASTIC FIBRE FORMATION%REACTOME%R-RNO-1566948.1 Elastic fibre formation Itgb6 Itgb8 LOC102553715 Vtn Itga8 Fbn1 Efemp1 Furin Efemp2 Fbln2 LOC100911714 Fbln1 Fbln5 Lox Mfap2 Gdf5 Ltbp3 Ltbp2 Mfap5 Ltbp4 Mfap4 Eln Ltbp1 Bmp2 Loxl4 Bmp7 Bmp4 Mfap3 Tgfb2 Loxl1 Tgfb1 Tgfb3 FGFR4 LIGAND BINDING AND ACTIVATION%REACTOME%R-RNO-190322.1 FGFR4 ligand binding and activation Fgf23 Fgf4 Fgf1 Fgf16 Fgf17 Fgf6 Fgf19 Fgf9 Fgf2 Fgf8 Fgf20 Fgfr4 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION%REACTOME%R-RNO-400508.1 Incretin synthesis, secretion, and inactivation Gnat3 Dpp4 Lep Grp Gip Gpr119 Ffar4 Gnb3 Gcg Ffar1 Gng13 METALLOTHIONEINS BIND METALS%REACTOME%R-RNO-5661231.1 Metallothioneins bind metals Mt3 INSULIN PROCESSING%REACTOME DATABASE ID RELEASE 66%10145456 Insulin processing Slc30a5 Exoc8 Exoc7 Slc30a6 Slc30a8 Ero1l Ins1 Ero1lb Ins2 Exoc3 Exoc2 Exoc1 Exoc6 Exoc5 ANCHORING FIBRIL FORMATION%REACTOME%R-RNO-2214320.1 Anchoring fibril formation Bmp1 Lamc2 Tll2 Col7a1 Tll1 Lamb3 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF UNSATURATED FATTY ACIDS%REACTOME DATABASE ID RELEASE 66%10144949 mitochondrial fatty acid beta-oxidation of unsaturated fatty acids Decr1 Eci1 Acadm SCAVENGING BY CLASS A RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145956 Scavenging by Class A Receptors Hsp90b1 Calr Colec12 Scgb3a2 Apob Apoa1 Apoe Marco Msr1 CLATHRIN DERIVED VESICLE BUDDING%REACTOME%R-RNO-421837.1 Clathrin derived vesicle budding Ftl1 LOC100909548 Igf2r Necap1 Clvs1 Picalm Chmp2a Tgoln2 Hip1r Tfrc App Vamp2 Dnm2 Ap1m2 Gbf1 Snx5 Snx9 Snx2 Acbd3 Sort1 Cpd Dnase2 Clint1 Yipf6 Ap4s1 Ap1b1 Vamp8 Tpd52 Sh3gl2 Stx4 Ocrl Ap4e1 Golgb1 Ap4b1 Ap1g2 RGD1561661 Ctsz Napa Tpd52l1 Cltc Cltb Snapin Ap1m1 Clta Ap3b1 LOC100360087 Bloc1s3 Pum1 Txndc5 Ap4m1 Bloc1s4 Bloc1s1 Bloc1s6 Rab5c Arrb1 M6pr Ap1s3 Ap1s1 Ap1s2 Pik3c2a Gak Vamp7 SCAVENGING BY CLASS H RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145959 Scavenging by Class H Receptors Stab2 Apob Sparc POLB-DEPENDENT LONG PATCH BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 66%10146093 POLB-Dependent Long Patch Base Excision Repair Parp2 Fen1 Parp1 LOC100911727 Adprhl2 Parg Apex1 Polb Lig1 MACROAUTOPHAGY%REACTOME%R-RNO-1632852.1 Macroautophagy Chmp2b Chmp2a Uvrag Atg16l1 Wipi1 Wipi2 Ulk1 Mtmr14 Atg7 Atg13 Atg14 Atg10 Ambra1 Atg3 RragB Lamtor3 Prkab1 Chmp4b Prkab2 Chmp4c Chmp4bl1 Lamtor2 Lamtor1 Dynll2 Atg12 Map1lc3a Gabarap Chmp7 Mtmr3 Chmp6 Chmp3 Mtor Rheb Prkag3 Gabarapl2 Pik3c3 Rptor Lamtor4 Tsc1 Lamtor5 Mlst8 Pik3r4 Prkaa1 Tsc2 Rraga Prkaa2 Rragc Becn1 Rb1cc1 Atg101 Rragd Atg4c Slc38a9 Atg4d Gabarapl1 Atg9a Atg9b Wdr45b GOLGI ASSOCIATED VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 66%10145614 Golgi Associated Vesicle Biogenesis Ftl1 Necap1 Igf2r Picalm Tgoln2 Hip1r Tfrc Dnm2 Vamp2 Ap1m2 Snx5 Snx9 Snx2 Acbd3 Sort1 Cpd Clint1 Yipf6 Ap1b1 Vamp8 Tpd52 Sh3gl2 Ocrl Ap4e1 Golgb1 Ap4b1 RGD1561661 Napa Tpd52l1 Cltc Snapin Ap1m1 Clta Ap3b1 LOC100360087 Bloc1s3 Txndc5 Pum1 Bloc1s4 Bloc1s1 Rab5c Bloc1s6 Arrb1 Ap1s3 Ap1s1 Ap1s2 Pik3c2a Gak Vamp7 HEDGEHOG LIGAND BIOGENESIS%REACTOME%R-RNO-5358346.1 Hedgehog ligand biogenesis Psmc6 Psmb10 Psmb8 Psmb9 Psmb4 Psmb11 Psmb5 Psmf1 Psmb6 Psmd4 Vcp Psmb2 Psmd5 Psmd8 Psmd9 Psmb3 Psma8 Psmd11 Psmd12 Psmd13 Psmd14 Disp2 Psmc3 G6pc Dhh Shh Psmb7 Psmb1 Ihh Os9 Erlec1 P4hb Psma5 Psma2 Psmc5 Psmd2 Psma1 Psma4 Psmc1 Psma3 Psmc4 Psmc2 Psma6 Psme1 Psmd1 Psme2 Psmd7 Scube2 Psmd3 Sel1l Psmd6 SIGNALING BY NTRK3 (TRKC)%REACTOME DATABASE ID RELEASE 66%10146326 Signaling by NTRK3 (TRKC) Src Plcg1 Ntrk3 Ntf3 SIGNALING BY NTRK2 (TRKB)%REACTOME DATABASE ID RELEASE 66%10146316 Signaling by NTRK2 (TRKB) Gab1 Crk Dock7 Rac1 Hgf Ntf4 Ntrk2 Bdnf Plcg1 Crkl Sos1 Frs2 LOC100911248 Grb2 NEGATIVE REGULATION OF NOTCH4 SIGNALING%REACTOME DATABASE ID RELEASE 66%10146331 Negative regulation of NOTCH4 signaling Notch4 Akt1 ERBB2 ACTIVATES PTK6 SIGNALING%REACTOME%R-RNO-8847993.1 ERBB2 Activates PTK6 Signaling Ereg Nrg1 Btc LOC102552659 Erbb3 Erbb2 Nrg3 Egfr Hbegf Nrg4 Ptk6 Erbb4 Nrg2 WNT MEDIATED ACTIVATION OF DVL%REACTOME DATABASE ID RELEASE 66%10145393 WNT mediated activation of DVL Csnk2a2 Csnk2b Dvl2 Pip5k1b Dvl3 Csnk1e Csnk2a1 Dvl1 LOC100361515 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY%REACTOME%R-RNO-2173795.1 Downregulation of SMAD2 3:SMAD4 transcriptional activity Smad3 Smad2 Parp1 Usp9x Ube2d1 Skil Ncor2 Hdac1l Hdac1 Tgif2 Tgif1 Trim33 Ube2d3 REGULATION OF IGF ACTIVITY BY IGFBP%REACTOME%R-RNO-381426.1 Regulation of IGF Activity by IGFBP Hrc Mbtps1 Fuca2 Shisa5 Mfi2 Bpifb2 Vwa1 LOC100911764 Sdc2 Igfbp6 Amtn Cyr61 Igfbp2 Pappa2 Klk1c12 Csf1 Serpind1 Klk1c10 Wfs1 Chgb Igfbp1 Igfbp5 Mgat4a Igfbp4 Enam Kng1l1 LOC100909521 Afp Serpinc1 Bmp4 Mfge8 F2 Igfbp7 Notum LOC304903 Calu Bmp15 Aplp2 Mepe Gzmf Apoa1 Gzmn Timp1 LOC100910060 Pcsk9 Dmp1 Amelx LOC691670 Prkcsh Pnpla2 Fam20c Plg Tmem132a Mxra8 Lgals1 Nucb1 Fam20a Mmp1 Mmp2 Ambn Tgoln2 Gas6 Fgf23 Apol2 Hsp90b1 App Msln RGD1309808 Lamc1 Tf Apol11a Apol3 Vgf LOC100910885 Apol9a Fbn1 Fstl1 Stc2 Igf2 Fstl3 Igf1 Prss23 Fgg Apob Chrdl1 Apoe Fga Apoa2 Cst3 Lamb1 Lamb2 Qsox1 Scg2 Spp1 C4a Scg3 Ktn1 C4b Il6 Sparcl1 LOC100909666 LOC102549354 Men1 Ctsg Penk LOC100911615 Kng1 Rcn1 Eva1a Kng2 Fn1 Vcan P4hb Cdh2 Pappa Igfals Dnajc3 C3 Ltbp1 Klk10 Klk1c6 Klk13 Klk1c8 Ckap4 Serpina10 Klk1c9 Cp Klk1c2 Klk1c3 EUKARYOTIC TRANSLATION TERMINATION%REACTOME DATABASE ID RELEASE 66%10146146 Eukaryotic Translation Termination N6amt1 Trmt112 Apeh Gspt1 Etf1 Gspt2 ACTIVATED NTRK3 SIGNALS THROUGH PLCG1%REACTOME DATABASE ID RELEASE 66%10146327 Activated NTRK3 signals through PLCG1 Plcg1 Ntrk3 Ntf3 THE NLRP1 INFLAMMASOME%REACTOME DATABASE ID RELEASE 66%10145732 The NLRP1 inflammasome Bcl2 Nlrp1a SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP)%REACTOME%R-RNO-400511.1 Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) Dpp4 Gip Gpr119 Ffar1 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER%REACTOME%R-RNO-76061.1 RNA Polymerase III Transcription Initiation From Type 1 Promoter Bdp1 Polr3d Polr3c Polr3a Polr3e RGD1565904 Polr3b Polr3h Polr2h Polr3k Polr2e Polr2f Polr1c Polr3g Polr2k Polr3f Gtf3c6 Gtf3c5 Gtf3c1 LOC100912534 Gtf3c3 Gtf3c4 Polr3gl Brf1 Gtf3a Tbp TRANSCRIPTIONAL REGULATION BY MECP2%REACTOME%R-RNO-8986944.1 Transcriptional Regulation by MECP2 Hdac1 Hipk2 Hdac2 Sin3a Hdac1l MITOCHONDRIAL TRANSLATION%REACTOME%R-RNO-5368287.1 Mitochondrial translation Mrps11 Mrps12 Mrps16 Mrps14 Mrps18b Mrps18c Mrps10 Mrps18a Mrps33 Mrps34 Mrps21 Mrps35 Mrps17 Mrps15 Mrps31 Mrps30 Mrps24 Mrps23 Mrps22 mrpl9 Mrps28 Mrps27 Mrps26 Mrps25 Mrpl4 Mrpl3 Mrpl2 Oxa1l Mtrf1l LOC367117 Mrrf Mrpl1 Mrpl13 Mrpl10 Mrpl18 Mrpl19 Mrps9 Mrps2 Mrps5 Mrps7 Mrpl36 Mrpl37 Mrpl20 Mrpl14 Mrpl16 Mrpl12 Mrpl15 Mrpl41 Mrpl35 Mrpl40 Mrpl33 Mrpl34 Mrpl38 Mrpl32 Mrpl27 Mrpl23 Mrpl28 Mrpl30 Mrpl21 Mrpl54 Mrpl46 Mrpl55 Mrpl44 Mrpl43 Mrpl47 Mrpl49 Mrpl53 Mrpl48 Mrpl52 Mrpl51 Mrpl50 mrpl11 mrpl24 Chchd1 Dap3 Eral1 Gadd45gip1 Ict1 Ptcd3 Gfm2 Gfm1 PROTEIN LOCALIZATION%REACTOME DATABASE ID RELEASE 66%10146283 Protein localization Phyh Ide Nudt7 Hmgcl Coq2 Acot4 Acot8 Acox1 Ehhadh Dhrs4 Eci3 Gstk1 Hsd17b4 Mlycd Acot2 Acot5 Acaa1a Acaa1b Pex2 Agps Hao1 LOC497963 Hao2 Pex5 Ddo Baat Ndufb8 Pipox Gnpat Agxt Paox Amacr Pitrm1 Hscb Ldhd Otc Usp9x Ube2d1 LOC100911156 Cat Ube2d3 Crot Pex14 Pex10 Pex13 Pex12 Acox3 Acox2 Slc27a2 Pex26 Idh1 Lonp2 Tysnd1 Pex1 Crat Zfand6 Pex6 Pex7 LOC103690024 Mpv17 Ech1 Hacl1 Ephx2 Atp5b CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX%REACTOME%R-RNO-68689.1 CDC6 association with the ORC:origin complex Mcm8 E2f1 E2f3 Orc4 Orc5 Orc6 Orc1 Orc2 E2f2 Orc3 Cdc6 RESOLUTION OF D-LOOP STRUCTURES%REACTOME%R-RNO-5693537.1 Resolution of D-Loop Structures Bard1 Wrn Rbbp8 Rmi1 Rmi2 Rad51c LOC100911267 Rad51d Spidr Rad51 Eme2 Brca2 Eme1 Rtel1 Rad50 Atm Xrcc3 Brca1 Blm Slx4 Mus81 Slx1b Slc25a16 Palb2 Gen1 Xrcc2 Nbn Mre11a SPHINGOLIPID DE NOVO BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 66%10145630 Sphingolipid de novo biosynthesis Osbp Csnk1g2 Sgpl1 Cers1 Acer2 Acer1 Acer3 Cers2 Vapa Kdsr Degs2 Gdf1 Sptlc3 Sptlc1 Prkd3 Sptlc2 Fa2h Ppap2a Prkd1 Prkd2 Ppap2b Sgpp2 Sgms1 Vapb Sptssb Ormdl1 Sptssa Aldh3a2 Aldh3b1 Sphk2 Ormdl2 Col4a3bp LOC498300 Ppap2c Cers4 Cers3 Samd8 Cers6 RGD1564463 Degs1 CLEARANCE OF DOPAMINE%REACTOME%R-RNO-379401.1 Clearance of dopamine Maoa Comt Slc6a3 Lrtomt GABA SYNTHESIS%REACTOME DATABASE ID RELEASE 66%10145746 GABA synthesis Gad2 Gad1 SUMOYLATION OF TRANSCRIPTION COFACTORS%REACTOME DATABASE ID RELEASE 66%10145995 SUMOylation of transcription cofactors Ing2 Mbd1 Safb Park7 Pias3 Pias1 LOC100911274 Hipk2 Pias2 Phc1 Phc2 Scmh1 Cbx4 Cbx2 Cbx8 Sumo1 Bmi1 Daxx Rnf2 Sin3a Mkl1 Ring1 Sumo3 Phc3 Zfp131 Pcgf2 Ube2i Ddx5 Uhrf2 Nrip1 Topors Ncoa1 SIGNALING BY WNT%REACTOME DATABASE ID RELEASE 66%10145342 Signaling by WNT Plcb1 Pde6b Nlk Plcb3 Pde6a Rbx1 Csnk2a2 Leo1 Csnk2a1 Wnt9b Wnt9a Vps26a Wls LOC100361515 Lrp5 Lrp6 Wnt3 Rnf43 Daam1 Rspo1 Wnt7a Wnt2b Lgr4 Wnt7b Lgr6 Vps29 Lgr5 Wnt16 Rspo4 Vps35 Sox9 Wnt3a Rspo2 Wnt10a Usp8 Rspo3 Wnt6 Pde6g Pard6a Akt1 Hdac1 Gnao1 Gnat2 Prkca Cul1 Camk2a Map3k7 Pip5k1b LOC100909468 Xpo1 LOC100910771 Rac2 Gng10 Ppp2r5e G6pc Men1 Psmb7 Psmb1 Ppp2r5c Ppp2r5a Ppp2r5b Psma5 Dvl1 Psma2 Psmd2 Dvl2 Dvl3 Pfn1 Psmc2 Psmd1 Psmd7 Psmd3 Psmd6 Psmc6 Psmb10 Psmb8 Psmb9 Psmb4 Psmb11 Psmb5 Psmf1 Psmb6 Rac1 Psmd4 Psmb2 Psmd5 Psmd8 Psmd9 Psmb3 Psma8 Psmd11 Psmd12 Psmd13 Psmd14 Ap2a2 Psmc3 Rbbp5 Wnt5b Wnt5a Prickle1 Fzd1 Cltc Cltb Fzd3 Clta Fzd2 Fzd4 Ppp2cb Fzd7 Ppp2ca Fzd6 Skp1 Ppp2r1a Prkcb Ywhaz Ap2s1 Wnt1 Ppp3r1 Wnt11 Wnt4 Xiap Ap2a1 Tnks Ror1 Ror2 Ap2m1 Gnb3 Gnb5 Ppp2r1b Gnb2 Gnb1 Btrc Gng13 Gng12 Gng11 LOC100912034 Gnb4 Gng4 Gngt2 Gng5 Gngt1 Gng8 Gng3 Ctbp2 Apc Dkk1 Kremen2 Sost Chd8 Hist1h2bo Hist1h2bcl1 Hist2h3c2 Hist1h2bk Smurf1 H3f3b Smarca4 Hdac1l Tle3 Tnks2 Crebbp LOC100910717 Akt2 Peg12 LOC100910200 Amer1 Cdc73 H2afx Csnk1a1 Hist1h4b Frat2 LOC684841 Hist1h2bh LOC100912290 Hist1h2ail1 Hist1h4m LOC102549173 LOC103690002 Tert LOC100910152 LOC100912338 Hist1h3c H2afb3 Hist1h3f Hist2h4 LOC684819 Hist1h3a H2afj Hist2h2aa3 Hist1h2bq Hist2h2aa2 Ash2l LOC100364835 LOC684762 Sox2 Hecw1 Csnk2b Dact1 Wnt8a Sox7 Sox6 Sry Sox17 Ctnnbip1 Ryk Wnt8b Dkk2 Dkk4 Cby1 Sox13 RGD1560225 Psmc5 Pygo2 Psma1 Ppp3ca Psma4 Arrb2 Psmc1 Rhoa Psma3 Csnk1e Psmc4 Psma6 Psme1 Hist1h2bg Tcf7 Psme2 Lef1 Tcf7l1 LOC680097 Bcl9l LOC684797 Tle4 LOC100912418 Tle1 Hist1h2ba Tle2 Hist3h2bb Pygo1 ESTROGEN BIOSYNTHESIS%REACTOME%R-RNO-193144.1 Estrogen biosynthesis Akr1b7 Akr1b8 Hsd17b14 Hsd17b1 Hsd17b2 Cyp19a1 Hsd17b11 SUMOYLATION OF CHROMATIN ORGANIZATION PROTEINS%REACTOME%R-RNO-4551638.1 SUMOylation of chromatin organization proteins Nup93 Nup43 Nup98 Nup133 Nup107 Pias1 Aaas Nup210 Npap60 Nup35 Nup37 Nupl2 Nupl1 Pias2 Scmh1 Cbx4 Cbx2 Cbx8 Sumo1 Bmi1 Hdac2 Rnf2 Ring1 Sumo3 Hdac1l Phc3 Pcgf2 Hdac4 Nup205 Ube2i Ranbp2 Satb2 Satb1 Hist1h4b LOC100912290 Nup155 Hist1h4m Hdac1 LOC100911274 Nup88 Hist2h4 Nup85 Phc1 Nup153 Phc2 Tpr Rae1 Nup54 Pom121 LOC680097 Nup62 LOC100912418 CLEAVAGE OF THE DAMAGED PURINE%REACTOME DATABASE ID RELEASE 66%10144974 Cleavage of the damaged purine Mpg Ogg1 Mutyh DEPOLYMERISATION OF THE NUCLEAR LAMINA%REACTOME DATABASE ID RELEASE 66%10146031 Depolymerisation of the Nuclear Lamina Cnep1r1 Cdk1 Lmnb1 Lemd3 Lmna Lemd2 Ctdnep1 Lpin2 Prkca Lpin3 Prkcb Lpin1 Tmpo EPIGENETIC REGULATION OF GENE EXPRESSION%REACTOME DATABASE ID RELEASE 66%10145445 Epigenetic regulation of gene expression Myo1c Kat2a RGD1565904 Polr1b Taf1d Taf1c Polr2h Cd3eap Polr2e Znrd1 Polr2f Polr1c Polr1a Polr2k Tdg Hist1h2bo Hist1h2bcl1 Hist2h3c2 LOC100912534 Hist1h2bk Actb H3f3b Sf3b1 Smarca5 Suv39h1l1 Tbp Eed LOC100910200 H2afx Hist1h4b Phf19 LOC684841 Hist1h2bh Dnmt1 LOC100912290 Rbbp7 Hist1h2ail1 Hist1h4m Mybbp1a LOC102549173 LOC103690002 LOC100910152 Dnmt3a LOC100912338 Hist1h3c H2afb3 Hist1h3f Ercc6 Dnmt3b Hist2h4 LOC684819 Hist1h3a H2afj Rrp8 Hist2h2aa3 Suv39h1 Hist1h2bq Hist2h2aa2 Mtf2 Ddx21 Phf1 LOC100364835 Baz1b LOC684762 Twistnb Polr1e Jarid2 Hist1h2bg Mbd2 Ezh2 LOC680097 LOC684797 LOC100912418 Hist1h2ba Dek Hist3h2bb Aebp2 REACTIONS SPECIFIC TO THE HYBRID N-GLYCAN SYNTHESIS PATHWAY%REACTOME%R-RNO-975574.1 Reactions specific to the hybrid N-glycan synthesis pathway Mgat3 RHO GTPASES ACTIVATE PAKS%REACTOME%R-RNO-5627123.1 RHO GTPases activate PAKs Flna Myh14 Myh11 Ppp1r12a LOC102551071 Ppp1cb Rac1 Cdc42 LOC100911597 Limk1 Nf2 Myh9 Pak2 Pak3 Pak1 Mylk DEGRADATION OF DVL%REACTOME DATABASE ID RELEASE 66%10145877 Degradation of DVL Psmc6 Psmb10 G6pc Psmb8 Psmb9 Psmb4 Psmb11 Psmb5 Psmf1 Psmb6 Psmd4 Psmb2 Rbx1 Psmd5 Psmd8 Psmb7 Psmd9 Psmb1 Psmb3 Psma8 Psmd11 Psmd12 Psmd13 Psmd14 Hecw1 Dact1 Psma5 Dvl1 LOC100361515 Psma2 Psmc5 Psmc3 Psmd2 Psma1 Dvl2 Psma4 Dvl3 Psmc1 Psma3 Psmc4 Psmc2 Psma6 Psme1 Psmd1 Psme2 Psmd7 Psmd3 Psmd6 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS%REACTOME DATABASE ID RELEASE 66%10145193 TGF-beta receptor signaling activates SMADs Smad3 Smad2 Nedd8 Fkbp1a Strap Tgfbr1 Ube2m Cbl Mtmr4 Tgfbr2 Zfyve9 Pmepa1 Tgfb1 Bambi Furin Stub1 PYRUVATE METABOLISM%REACTOME%R-RNO-70268.1 Pyruvate metabolism Bsg Glo1 Pdpr Rxra Pdhb Pdk3 Pdk4 Pdk1 Pdk2 LOC100365902 Pdha2 Pdha1 Pdhx Ppard Slc16a3 Pdha1l1 Slc16a8 Slc16a1 Ldhc Ldha Gstz1 Vdac1 Ldhb Pdp1 Hagh Dlat Me1 Dld PLATELET ACTIVATION, SIGNALING AND AGGREGATION%REACTOME DATABASE ID RELEASE 66%10145027 Platelet activation, signaling and aggregation Stxbp3 Tex264 F13a1 Ola1 Ly6g6f Ctsw Selp Serpina4 Pcyox1l Tor4a Islr Cdc37l1 Gnaq Chid1 Gna11 Fam3c Lhfpl2 Gna14 Nhlrc2 Gna15 Itih4 Mmrn1 Rarres2 Itih3 Lefty2 Serpine1 Ecm1 Anxa5 Tagln2 Gtpbp2 Timp3 Lefty1 LOC100910414 Plek Sccpdh Phactr2 Fyn Cd9 Kng1l1 A1bg Stx4 Ptk2 Gnai3 Aplp2 Figf Vegfc Vegfb Akt1 Pdgfa Brpf3 Apoa1 Pdgfb Timp1 Pik3cg Abcc4 A2m Tln1 Crk Vwf Apbb1ip Bcar1 G6b Actn4 Vegfa Habp4 Pcdh7 Apool Apoh Wdr1 Plg Srgn Prkca LOC100911881 Lyn Lgals3bp Sytl4 LOC100912012 Fermt3 Rhob Syk Cyb5r1 Maged2 Sparc Sod1 Actn2 Aldoa App Flna Clu Cd63 Serping1 Prkcq Fgb Fgg Thbs1 Hgf Fga Rac2 Aldoart2 Qsox1 Actn1 Gng10 LOC685953 Cd36 Tbxa2r Gna12 Kng1 Vav2 Gna13 Vav1 Kng2 Fn1 Csk Vav3 Rasgrp1 Rap1a Fcer1g Pdpk1 Cdc42 Pros1 Ptpn6 Itga2b Trpc3 Trpc7 Trpc6 Psap Raf1 Ptpn1 Rac1 Lamp2 Cfd Rasgrp2 Adra2b Gp1ba Gp9 Gp5 Gp1bb LOC100911551 F2rl3 Tgfb2 F2r Tgfb1 F8 F2 Tgfb3 F2rl2 Pik3r5 Src Pf4 Pik3r3 Cd109 Pik3r6 Rab27b Dgkk Dgki Gnat3 Prkcb Ywhaz Dgkg Dgkd Dgke Dgka Dgkb Gnb3 Gnb5 Gnb2 Gnb1 Gng13 Gng12 Mapk1 Gng11 Itpr1 Rapgef4 Dgkz Itpr3 Dgkq LOC100912034 Gnb4 Dgkh Gng4 Mapk14 Gngt2 Serpina3m Gng5 Gngt1 Prkch Gng8 Gng3 Vcl Gas6 Pla2g4a Tf Mgll Abhd12 Daglb Abhd6 Dagla Igf2 Igf1 RGD1565355 Prkcd P2ry1 Scg3 Pik3r1 Pik3r2 Stxbp2 LOC299277 P2ry12 Adra2a Gnai2 Adra2c Ppbp Arrb1 Pik3cb Tuba4a Ptpn11 Arrb2 Rhoa Lat Gnai1 Rhog Sos1 Lcp2 Shc1 Grb2 LOSS OF NLP FROM MITOTIC CENTROSOMES%REACTOME%R-RNO-380259.1 Loss of Nlp from mitotic centrosomes Dync1i2 Cep57 LOC691918 Haus3 Ninl Akap9 Ccp110 Dync1h1 Pafah1b1 LOC103692716 Dctn1 Cntrl Dctn2 Cep76 Pcm1 Cep78 LOC100911033 Cep164 Dctn3 Cep41 Ofd1 Sdccag8 Tubb5 Prkar2b Cenpj Ywhag Ppp2r1a Plk4 Ywhae LOC100912076 Tubg2 Haus2 Haus1 Haus5 Alms1 Clasp1 Haus4 Odf2 Tubb4a Cdk1 Nek2l1 Ssna1 Mapre1 Tubg1 Cep63 Prkaca Csnk1d Cep131 Tuba4a Cep250 Cep135 Csnk1e Ckap5 Cdk5rap2 Pcnt Nek2 Cep72 Sfi1 Cep70 Actr1a Nedd1 CAM PATHWAY%REACTOME DATABASE ID RELEASE 66%10144992 CaM pathway Prkcd Pde1b Adcy8 Adcy9 Adcy5 Adcy4 Adcy7 Adcy6 Prkar1b Prkar1a Prkaca Prkacb Adcy3 Prkar2b Prkca Prkar2a Camk4 Adrbk1 SIGNALING BY SCF-KIT%REACTOME DATABASE ID RELEASE 66%10145420 Signaling by SCF-KIT Stat5a Ptpru Src Kras Grb7 Stat1 Pik3r3 Pik3r1 Mmp9 Pik3r2 Stat3 Rac1 Grap Fer Vav1 Cma1 Fyn Cbl Grb10 Ptpn11 Tec Fes Ptpn6 Prkca Lyn Hras Yes1 Nras Sh2b2 Sos1 Kit Kitlg Grb2 TIGHT JUNCTION INTERACTIONS%REACTOME%R-RNO-420029.1 Tight junction interactions Prkci Crb3 Pard6a Pard3 Pard6g Mpp5 F11r Inadl Pard6b NUCLEOTIDE METABOLISM%REACTOME DATABASE ID RELEASE 66%10144816 Nucleotide metabolism Cda Adprm Nudt9 Nt5c2 Nudt5 Nudt16 Adal Nudt18 LOC688828 Uck1 Entpd2 Tymp Dck Entpd6 Entpd3 Entpd4 Entpd1 Entpd7 Entpd5 Entpd8 Txnrd1 Gsr Tyms Dtymk LOC305806 Nme3 Nudt13 Nme1 Ak5 Pnp Ak4 Ak6 Ak8 Rrm2b Dut Ctps2 LOC100909857 Ctps1 Aprt Uckl1 Tk2 Hdhd1 Uck2 Upp1 Upp2 Tk1 Glrx Nudt15 Rrm2 Rrm1 Nudt1 Dctd LOC100360124 LOC100359853 Guk1 Nt5c1a Nt5c Nt5c3a Nt5e Upb1 Nt5m Impdh1 Impdh2 Gmpr2 Ampd1 Gmpr Nme2 Xdh Dpys Dguok Hprt1 Ada Ampd2 Ampd3 Txn1 Pfas Cad Ppat LOC100912917 Adss Gmps Nt5c1b Lhpp Atic Gda Gart Adsl Itpa Samhd1 Adssl1 Umps Dhodh Paics Dnph1 INHIBITION OF ADENYLATE CYCLASE PATHWAY%REACTOME%R-RNO-997269.1 Inhibition of adenylate cyclase pathway Gnat3 Adcy8 Adcy9 Gnai3 Adcy5 Adcy3 Adcy4 Gnai2 Adcy7 Adcy6 Gnal Gnai1 RNA POLYMERASE II TRANSCRIBES SNRNA GENES%REACTOME DATABASE ID RELEASE 66%10146187 RNA polymerase II transcribes snRNA genes Ints4 Ints5 Ints6 Ints7 Ints9 Phax Ints1 Ints3 Ints2 Pcf11 RGD1565904 Ice2 Zc3h8 Polr2g Polr2h Polr2e Polr2f Polr2j Polr2k Polr2d Polr2i Polr2b Polr2c Ssu72 Polr2a Ice1 Vwa9 Gtf2f1 LOC100912534 Gtf2f2 Ell Gtf2a1 Pou2f1 Nabp1 Nabp2 Tbp Ccnt2 Rprd1a Gtf2e1 Sp1 Gtf2e2 Snapc3 Snapc4 Cdk9 Taf11 Taf13 Taf9 Ccnk Ell3 LOC100911822 Supt5h Ell2 Rpap2 Cpsf3l Rprd1b Taf6 Taf5 Taf8 Ncbp2 Ncbp1 Supt4h1 Cdk7 Gtf2b Asun RGD1562299 Snapc5 Snapc2 MRNA DECAY BY 3' TO 5' EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 66%10145639 mRNA decay by 3' to 5' exoribonuclease Wdr61 Hbs1l Dcps Exosc9 Exosc2 Exosc1 Nt5c3b Exosc4 Ttc37 Exosc7 Exosc5 Exosc3 AMINE-DERIVED HORMONES%REACTOME%R-RNO-209776.1 Amine-derived hormones Aanat Slc5a5 Asmt Tph1 Tpo Pnmt Tph2 Iyd Duox2 Ddc Duox1 Tshb Dbh Cga Th PROGRESSIVE TRIMMING OF ALPHA-1,2-LINKED MANNOSE RESIDUES FROM MAN9 8 7GLCNAC2 TO PRODUCE MAN5GLCNAC2%REACTOME%R-RNO-964827.1 Progressive trimming of alpha-1,2-linked mannose residues from Man9 8 7GlcNAc2 to produce Man5GlcNAc2 Man1c1 Man1a2 Man1a1 AMINO ACID AND DERIVATIVE METABOLISM%REACTOME%R-RNO-71291.1 Amino acid and derivative metabolism Smox Sat1 RGD1564480 Slc7a5 Slc6a7 Oca2 Slc45a2 Tyrp1 Tyr LOC308670 Paox Mccc2 Fah Mccc1 Tat Gcsh LOC100911156 Sds Hrsp12 Pcbd1 Sdsl Aanat Hpd Phykpl Asmt Tph1 Tph2 Hgd Il4i1 Pah Asrgl1 Agmat Qdpr Enoph1 Mtap Mri1 Adi1 Pnmt Ddc Dbh Th Nmral1 Ass1 Nags Cps1 Slc25a2 Pipox Aldh7a1 Gcdh Aadat Dlst Slc25a10 Hykk Ogdh G6pc Serinc4 Psph Rimklb Serinc2 Gpt Serinc3 Srr Aspa Arg1 Nat8l Serinc1 Naalad2 Pdhb Folh1 Pycrl Psmb7 Aldh18a1 Psmb1 Oat Asns Pycr2 LOC100365902 Pycr1 Pdha2 Pdha1 Pdhx Pdha1l1 Slc36a4 Gstz1 Psma5 Shmt1 Dlat Psma2 Psmd2 Psat1 Phgdh Psmc2 Psmd1 Psmd7 Psmd3 Dld Psmd6 Nqo1 Slc6a11 Ndufab1 Psmc6 Oaz3 Slc6a12 Psmb10 Sardh Oaz1 Dmgdh Oaz2 Psmb8 LOC683884 Chdh Psmb9 Psmb4 Psmb11 Psmb5 Psmf1 Psmb6 Psmd4 Psmb2 Psmd5 Psmd8 Got1 Psmd9 Psmb3 Azin1 Psma8 Psmd11 Psmd12 Txnrd1 Psmd13 Psmd14 Got2 Acat1 Psmc3 LOC100910122 Tpo Iyd Duox2 Mat1a Duox1 Tshb Cga Ahcy Mtrr Mtr Ckb Sms LOC100912604 Ckmt1b Amd1 Gamt LOC100364487 Srm Kmo Kynu Ccbl1 Ido1 Tdo2 Lipt2 Amdhd1 Lipt1 Carns1 Agxt2 Hnmt Hal Bckdhb Amt Grhpr Hdc Ftcd Hao1 Hoga1 Uroc1 Gnmt Tas1r2 Ddo Dhtkd1 LOC100911564 Aldh4a1 Dbt Gldc Glul Agxt Iffo2 Lias Mpst Txn2 Suox Bckdk Cbs Bcat1 Sqrdl Bhmt2 Hsd17b10 Otc Ethe1 Bcat2 Hibadh Cdo1 Auh Cth Aldh6a1 Tstd1 Ivd Tst Acadsb Hibch Tmlhe Ppm1k Psmc5 Slc5a5 Psma1 Psma4 Psmc1 Psma3 Psmc4 Psma6 Psme1 Prodh Odc1 Psme2 Scly INOSITOL PHOSPHATE METABOLISM%REACTOME%R-RNO-1483249.1 Inositol phosphate metabolism Plcb1 Inpp1 Inpp5a Pten Isyna1 Plcb3 Synj1 Impa1 Inpp4a Impa2 Inpp4b Inpp5d Inpp5j Plcd3 Plcz1 Ipmk Plcd1 Ip6k2 Plcd4 Inpp5b Itpka Plce1 Pld4 Plch1 Plch2 Plcb4 Nudt11 LOC100912928 Nudt3 Minpp1 Ppip5k1 Ppip5k2 Nudt10 Plcg1 Ip6k1 Ippk Itpkb Nudt4 Itpkc Itpk1 Ocrl FORMATION OF ATP BY CHEMIOSMOTIC COUPLING%REACTOME DATABASE ID RELEASE 66%10145126 Formation of ATP by chemiosmotic coupling LOC100911417 Atp5f1 LOC500350 Atp5g3 Atp5l Atp5g2 Atp5o Atp5h Mt-atp6 Atp5i Atp5j Atp5j2 Atp5s Atp5e Atp5d Mt-atp8 Atp5b ACTIVATION OF SMO%REACTOME DATABASE ID RELEASE 66%10146091 Activation of SMO Csnk1a1 Dhh Cdon Shh Ptch1 Efcab7 Smo Iqce Evc2 Kif3a Arrb1 Boc Arrb2 Gas1 Ihh Gas8 Evc Adrbk1 GLI3 IS PROCESSED TO GLI3R BY THE PROTEASOME%REACTOME DATABASE ID RELEASE 66%10146075 GLI3 is processed to GLI3R by the proteasome Psmc6 Psmb10 Psmb8 Psmb9 Psmb4 Psmb11 Psmb5 Psmf1 Psmb6 Psmd4 Rbx1 Cul1 Psmb2 Psmd5 Psmd8 Psmd9 Psmb3 Psma8 Psmd11 Psmd12 Psmd13 Psmd14 Psmc3 Csnk1a1 Sufu G6pc Psmb7 Psmb1 Gli3 Skp1 Psma5 Btrc Psma2 Prkaca Psmc5 Psmd2 Prkacb Psma1 Psma4 Psmc1 Psma3 Psmc4 Psmc2 Psma6 Psme1 Psmd1 Psme2 Psmd7 Psmd3 Psmd6 RELEASE OF HH-NP FROM THE SECRETING CELL%REACTOME DATABASE ID RELEASE 66%10146062 Release of Hh-Np from the secreting cell Disp2 Dhh Ihh Shh Scube2 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES%REACTOME%R-RNO-2022090.1 Assembly of collagen fibrils and other multimeric structures Mmp7 LOC100911730 Mmp9 Pcolce RGD1308751 Cd151 Lamc2 Itgb4 Itga6 Col5a2 Col5a1 Cts8l1 Col4a5 Col9a1 Col27a1 Col9a2 Col9a3 Lox Col4a1 Plec Col5a3 LOC100364523 Bmp1 Col4a2 Col7a1 Lamb3 Dst Mmp13 Ctsb Col8a1 Ctsl Col8a2 Col3a1 Ctsm Ctsj RGD1564657 Col1a1 Ctsq Ctsr Col1a2 Col18a1 MGC114246 Tll2 Col11a2 Col11a1 Mmp20 Tll1 Testin Loxl4 Cts8 Cts7 Loxl1 RGD1564827 PEROXISOMAL PROTEIN IMPORT%REACTOME DATABASE ID RELEASE 66%10146282 Peroxisomal protein import Phyh Ide Nudt7 Hmgcl Acot4 Acot8 Acox1 Ehhadh Dhrs4 Eci3 Gstk1 Hsd17b4 Mlycd Acot2 Acot5 Acaa1a Acaa1b Pex2 Agps Hao1 LOC497963 Hao2 Pex5 Ddo Baat Pipox Gnpat Agxt Paox Amacr Usp9x Ube2d1 LOC100911156 Cat Ube2d3 Crot Pex14 Pex10 Pex13 Pex12 Acox3 Acox2 Slc27a2 Pex26 Idh1 Lonp2 Tysnd1 Pex1 Crat Zfand6 Pex6 Pex7 LOC103690024 Mpv17 Hacl1 Ech1 Ephx2 RECYCLING PATHWAY OF L1%REACTOME DATABASE ID RELEASE 66%10145501 Recycling pathway of L1 Ap2a2 Src Dnm1 Dnm3 Rdx Kif4a Msn Cltc Mapk1 Dpysl2 L1cam Ezr Clta Dnm2 Sh3gl2 Ap2s1 Ap2a1 Ap2m1 VASOPRESSIN REGULATES RENAL WATER HOMEOSTASIS VIA AQUAPORINS%REACTOME%R-RNO-432040.1 Vasopressin regulates renal water homeostasis via Aquaporins Myo5b Prkar2b Prkar2a Rab11fip2 Avp Prkar1b Gnb3 Prkar1a Aqp4 Gnb5 Gnb2 Rab11a Gnb1 Gng13 Gng12 Aqp1 Gng11 Prkaca Prkacb LOC100912034 Gnb4 Gng4 Gngt2 Gng5 Gngt1 Gng10 Gng8 Gng3 PI5P REGULATES TP53 ACETYLATION%REACTOME%R-RNO-6811555.1 PI5P Regulates TP53 Acetylation Ing2 Map2k6 LOC364561 Pin1 LOC100910954 Tmem55b Pip4k2b Pip4k2c HYPUSINYLATION%REACTOME%R-RNO-204626.1 Hypusinylation Eif5a Dohh Dhps Eif5a2 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1%REACTOME DATABASE ID RELEASE 66%10144899 Ubiquitin-dependent degradation of Cyclin D1 Psmc6 Psmb10 G6pc Psmb8 Psmb9 Psmb4 Psmb11 Psmb5 Psmf1 Cdk4 Psmb6 Psmd4 Psmb2 Psmd5 Psmd8 Psmb7 Psmd9 Psmb1 Psmb3 Psma8 Ccnd1 Psmd11 Psmd12 Psmd13 Psmd14 Psma5 Psma2 Psmc5 Psmc3 Psma1 Psmd2 Psma4 Psmc1 Psma3 Psmc4 Psmc2 Psma6 Psme1 Psmd1 Psme2 Psmd7 Psmd3 Psmd6 VEGFA-VEGFR2 PATHWAY%REACTOME DATABASE ID RELEASE 66%10145272 VEGFA-VEGFR2 Pathway Abi1 Abi2 Rac1 Nos3 Nck1 Rock2 Rictor Cyfip1 Fyn Ncf1 Brk1 Ncf4 LOC103692716 Baiap2 Trib3 Cybb Cyba Pak2 Pak3 Pak1 Them4 Nckap1l Ptk2 Cyfip2 Nck2 Nckap1 Akt2 Sh2d2a Prkcd Hspb1 Wasf1 Kras Src Rock1 LOC100909609 Ptk2b Pik3r1 Pxn Pik3r2 Shc2 Jup Akt1 Axl Prkcb Vav2 Vav1 Prkcz Mtor Ctnna1 Mapk13 Mapk12 Kdr Dscam Vav3 Crk Bcar1 Mlst8 Mapkapk3 Pdpk1 Mapkap1 Mapkapk2 Cdc42 Prkaca Pik3cb Akt3 Vegfa Prkacb Rhoa Prkca Plcg1 Dock1 Hras Ctnnd1 Nras Cdh5 Elmo2 Mapk14 Rasa1 Shb Mapk11 TRANSCRIPTIONAL REGULATION BY RUNX3%REACTOME%R-RNO-8878159.1 Transcriptional regulation by RUNX3 Psmc6 Psmb10 Mdm2 Psmb8 Psmb9 Maml1 Psmb4 Rbpj Psmb5 Kat2a Zfhx3 Psmf1 Psmb6 Psmd4 Rbpjl2 Psmb2 Psmd5 Psmd8 Psmd9 Psmb3 Psmd11 Psmd12 Psmd13 Psmd14 Smurf1 Snw1 Psmc3 Cbfb Yap1 Tead2 Tead1 Hdac4 Tgfb1 Crebbp Smad3 Notch1 Kras Src G6pc Psmb7 Psmb1 Ccnd1 Psma5 LOC100910954 Psma2 Psmc5 Brd2 Psmd2 Psma1 Psma4 Psmc1 Psma3 Psmc4 Psmc2 Psma6 Psme1 Tcf7 Lef1 Psmd1 Psme2 Tcf7l1 Psmd7 Psmd3 Psmd6 TP53 REGULATES TRANSCRIPTION OF DNA REPAIR GENES%REACTOME DATABASE ID RELEASE 66%10146165 TP53 Regulates Transcription of DNA Repair Genes Ccnt2 Gtf2h1 Gtf2h2 Tceb3 Cdk9 Mnat1 RGD1565904 Cdk12 Ercc3 Polr2g Polr2h Polr2e Supt16h Polr2f Polr2j Polr2k Ccnk Supt5h Polr2d LOC100911822 Polr2i Polr2b Cdk13 Polr2c Ercc2 Polr2a Gtf2f1 LOC100912534 Gtf2f2 Ell Supt4h1 Cdk7 Tceb2 Tceb1 Tcea1 Nelfe Nelfa Nelfb Ccnh Ssrp1 Gtf2h3 Gtf2h5 Gtf2h4 PI-3K CASCADE:FGFR2%REACTOME DATABASE ID RELEASE 66%10145254 PI-3K cascade:FGFR2 Gab1 Fgf16 Fgf17 Pik3r1 Fgf10 Fgf9 Fgfr2 Fgf7 Fgf2 Fgf8 Fgf23 Fgf22 Fgf4 Ptpn11 Fgf1 Fgf3 Fgf6 Fgf5 Frs2 Fgf20 Grb2 TRANSLESION SYNTHESIS BY REV1%REACTOME DATABASE ID RELEASE 66%10144976 Translesion synthesis by REV1 Rfc1 Rfc2 Rev1 Rpa1 Rpa3 Rpa2 Mad2l2 Rfc5 Rev3l Rfc4 Rfc3 Pcna SHC1 EVENTS IN ERBB4 SIGNALING%REACTOME DATABASE ID RELEASE 66%10145825 SHC1 events in ERBB4 signaling Ereg Kras Nrg1 Btc Nrg3 Hbegf Nrg4 Erbb4 Hras Nras Sos1 Shc1 Nrg2 Grb2 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM%REACTOME DATABASE ID RELEASE 66%10144896 Transport of Mature Transcript to Cytoplasm Nup93 Rnps1 Thoc5 RGD1565693 Thoc7 Thoc3 Nup43 Thoc2 Nup98 Nup133 Thoc1 Nup107 Magohb Aaas Rbm8a Thoc6 Nup210 Npap60 Nxf7 Nup35 Gle1 Nxf2 Nup37 Nxf1 Nupl2 Ddx39a Nupl1 Ddx39b Chtop U2af1l4 Sarnp Tcp11x2 Nup205 Nxt1 Ranbp2 Slu7 Srsf3 Upf3b U2af2 Srsf6 Nup155 Srsf7 Srsf4 Srsf5 Srsf2 LOC679894 Nup88 Srsf9 Dhx38 Nup85 Magoh Nup153 Ncbp2 Srsf1 Poldip3 Ncbp1 Tpr Fyttd1 Rae1 Eif4a3 LOC100910660 Srrm1 Nup54 Pom121 Nup62 Cdc40 LOC361990 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 66%10144717 CDT1 association with the CDC6:ORC:origin complex Psmc6 Psmb10 Psmb8 Psmb9 Psmb4 Psmb11 Psmb5 Psmf1 Psmb6 Psmd4 Psmb2 Psmd5 Psmd8 Psmd9 Psmb3 Psma8 Psmd11 Psmd12 Psmd13 Psmd14 Psmc3 Mcm8 Orc4 Orc5 Orc6 Orc1 Orc2 Orc3 Cdc6 Gmnn G6pc Psmb7 Psmb1 Psma5 Cdt1 Psma2 Psmc5 Psmd2 Psma1 Psma4 Psmc1 Psma3 Psmc4 Psmc2 Psma6 Psme1 Psme2 Psmd1 Psmd7 Psmd3 Psmd6 ACTIVATION OF BMF AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%R-RNO-139910.1 Activation of BMF and translocation to mitochondria Dynll2 Mapk8 Bmf CELL CYCLE, MITOTIC%REACTOME DATABASE ID RELEASE 66%10144721 Cell Cycle, Mitotic Rfc1 Rfc2 Pole2 Kif23 Pole4 Mnat1 Rbx1 LOC100910252 Stag1 Pds5b Pds5a Cdca5 Rad21 Smc1a Stag2 Smc3 Esco2 Esco1 Rpa3 Pole Pcna Ccnh Rfc5 Rfc4 Rfc3 Ube2d1 Rbl1 Cdk4 Akt1 E2f4 Hdac1 Rpa1 Ccnd1 Rpa2 RGD1310212 Tfdp1 Lig1 Tfdp2 Kif20a Slc25a16 Fen1 Prkca Lyn Cul1 Ptk6 Ensa Arpp19 Psmb7 Psmb1 Dsn1 Psma5 LOC100911727 Cdk7 Pold2 Pold1 Psma2 Pold4 Psmd2 Psmc2 Psmd1 Psmd7 Psmd3 Psmd6 Cep57 Rab8a LOC691918 Haus3 Prim2 Ccne2 Pola2 Ninl Ccne1 Prim1 Akap9 Ccp110 Mcm2 Mcm4 Mcm3 Cdk2 Mcm5 Mcm6 Mcm10 Mcm8 Mcm7 Orc4 Orc5 Orc6 Orc1 Orc2 Setd8 Orc3 Cdc7 Cdc6 Cdc45 Ppp2cb Ppp2ca Skp1 Ppp2r1a Fbxw11 Ppp2r1b Btrc Mapk1 Akt3 Hist1h2bo Cnep1r1 Hist1h2bcl1 Rbl2 Hist2h3c2 Hist1h2bk Gorasp2 H3f3b Cks1l E2f5 Hdac1l Cables1 Numa1 Dyrk1a Lemd2 Cdkn2b Nek6 Blzf1 Cdkn2c Hdac8 Cdk6 Cks1b Nek7 LOC100909949 Dctn1 Gmnn LOC100910200 Ccnd3 Cntrl Mcph1 H2afx Hist1h4b Dctn2 RGD1563307 Cep76 LOC684841 Hist1h2bh Pcm1 Cep78 Rb1 Ncapg LOC100912290 E2f2 Hist1h2ail1 Lemd3 Hist1h4m LOC100911033 LOC102549173 Cep164 Mau2 LOC103690002 Dctn3 Cep41 LOC100910152 Lmna Ofd1 LOC100912338 Vrk2 Hist1h3c Sdccag8 Ncaph2 H2afb3 Lin37 Hist1h3f Vrk1 Ctdnep1 Prkar2b Cenpj Hist2h4 Lin52 LOC684819 Hist1h3a Plk4 Lin54 Smc4 H2afj Hist2h2aa3 Tmpo Hist1h2bq Espl1 Hist2h2aa2 Smc2 Gins3 Gins4 LOC100364835 Gins1 LOC684762 Gins2 LOC100912076 Tubg2 Haus2 Haus1 Haus5 Alms1 Haus4 Odf2 Tubb4a Cdt1 Lmnb1 Lin9 Ncapg2 Ssna1 Tubg1 Cep63 Csnk1d Cep131 Tuba4a Cep250 Cep135 Csnk1e Cdk5rap2 Hist1h2bg Pcnt Cep72 LOC680097 Sfi1 Cep70 LOC684797 Actr1a LOC100912418 Hist1h2ba Nedd1 Hist3h2bb Cenpn Zwilch Cenpl Cenpo Dync1li2 Cenpt Cenpu Bub3 Bub1 Spdl1 Kntc1 Dync1i2 Mad1l1 Csnk2a2 Cenpk Cenph Cenpi Csnk2a1 Cenpf Cenpe Cenpm Ahctf1 Ndel1 Rcc2 LOC100909750 Pafah1b1 Ppp1r12a Mis12 LOC102555167 Dynll2 Ndc80 Cenpc Cenpa Dync1i1 Birc5 Taok1 Nup88 Nup85 Anapc7 Cdc26 Cdc14a Cdc27 Cdc23 Pttg1 Ube2c Skp2 Cdkn1a Cdkn1b Anapc16 Cdc16 Rae1 Nek2l1 Anapc4 Anapc2 Anapc1 Lpin2 Lpin3 Lpin1 Nek2 Nup93 Nup98 Rab2a Nup107 Nup210 Anapc11 Nupl2 Anapc15 Aurka Anapc10 Nupl1 Fzr1 Fbxo5 Cdca8 Cdc25c Rangap1 Ppp1cb Ppp1cc LOC100909468 Aurkb Sec13 Xpo1 Rab1b Nup205 Rab1a LOC100911204 Spc24 Spc25 Abl1 Itgb3bp Sgol2 Ppp2r5e Incenp G6pc Nup155 Nsl1 B9d2 Cdc20 Kif2a Kif2c Kif2b Bub1b Kif18a Ppp2r5c Ppp2r5a Ppp2r5b Zwint Mad2l1 Casc5 Nup153 Clasp2 Ercc6l Nuf2 Clasp1 Tpr LOC679582 Mapre1 Cdc42 Pmf1 Nup54 Ckap5 Pom121 Ska2 Nup62 Sgol1 Zw10 Ska1 Psmc6 Nup43 Psmb10 Nup133 Psmb8 Psmb9 Psmb4 Aaas Psmb11 Psmb5 Psmf1 Psmb6 Psmd4 Psmb2 Psmd5 Npap60 Psmd8 Psmd9 Psmb3 Nup35 Psma8 Nup37 Psmd11 Psmd12 Ccna2 Ccna1 Psmd13 Psmd14 Psmc3 Ajuba Ranbp2 Src Hsp90ab1 Tubb5 Ywhag Prkcb Ywhae Prkaca Ppp2r3b Bora Fbxl18 Fkbpl Fbxl7 Ppme1 Foxm1 Lcmt1 Tubgcp2 Dync1h1 Dync1li1 LOC103692716 Akt2 Gorasp1 Csnk2b E2f1 E2f3 Tpx2 Cdk11b LOC100910954 Cdk1 Gtse1 Psmc5 Phlda1 Psma1 Cdc25b Psma4 Cdc25a Psmc1 Wee1 Psma3 Pkmyt1 Psmc4 Ppp2r2a Psma6 Psme1 Nme7 Tubgcp5 Psme2 Tubgcp6 Tubgcp3 Tubgcp4 Optn LOC100909844 LOC100363782 Mzt1 Mzt2b NEGATIVE REGULATION OF MET ACTIVITY%REACTOME%R-RNO-6807004.1 Negative regulation of MET activity Ptpn1 Cbl Ptprj Hgf Ptpn2 Stam2 Sh3gl2 Sh3gl1 Sh3kbp1 Sh3gl3 Lrig1 Stam Usp8 Grb2 MTOR SIGNALLING%REACTOME DATABASE ID RELEASE 66%10145128 mTOR signalling LOC100912571 Eif4ebp1 Akt1s1 Akt1 Cab39l LOC100911431 Eef2k RragB Eif4g1 Lamtor3 Ywhab Prkab1 Strada Stradb Eif4b Prkab2 Rps6kb1 Cab39 Mtor Rheb Lamtor2 Prkag3 Lamtor1 Rptor Lamtor4 Tsc1 Lamtor5 Mlst8 Prkaa1 LOC100911372 Tsc2 Rraga Prkaa2 Rragc Rragd Slc38a9 Rps6 LOC680559 Akt2 PURINE CATABOLISM%REACTOME%R-RNO-74259.1 Purine catabolism Nt5c1a Nt5c Adprm Nudt9 Nt5e Nudt5 Nt5c2 Nudt16 Nudt18 Pnp LOC688828 Xdh Nt5c1b Nudt15 Nudt1 Gda Itpa Dnph1 PHENYLALANINE AND TYROSINE CATABOLISM%REACTOME%R-RNO-71182.1 Phenylalanine and tyrosine catabolism Pcbd1 Hpd Gstz1 Fah Tat Ccbl1 Hgd Il4i1 Pah Asrgl1 Qdpr SYNTHESIS OF DIPHTHAMIDE-EEF2%REACTOME DATABASE ID RELEASE 66%10146058 Synthesis of diphthamide-EEF2 Dph1 Dph3 Eef2 Dph2 Dph5 Dph6 TRIGLYCERIDE CATABOLISM%REACTOME%R-RNO-163560.1 Triglyceride catabolism Fabp3 Fabp2 Fabp6 Fabp1 Fabp4 Fabp9 Fabp12 Pnpla5 Fabp7 RGD1562200 Fabp5 Plin3 Gpd2 CD28 CO-STIMULATION%REACTOME DATABASE ID RELEASE 66%10145354 CD28 co-stimulation Cd80 Cd86 Src Pik3r3 Pik3r1 Map3k8 Pik3r2 Rac1 Akt1 Cd28 Vav1 Rictor Mtor Fyn Mlst8 Pdpk1 Trib3 Mapkap1 Cdc42 Akt3 Map3k14 Pak2 Pak3 Pak1 Lyn Them4 Yes1 Akt2 Grb2 REMOVAL OF AMINOTERMINAL PROPEPTIDES FROM GAMMA-CARBOXYLATED PROTEINS%REACTOME%R-RNO-159782.1 Removal of aminoterminal propeptides from gamma-carboxylated proteins Pros1 Proz Bglap F2 F7 F9 Gas6 Furin EGFR TRANSACTIVATION BY GASTRIN%REACTOME%R-RNO-2179392.1 EGFR Transactivation by Gastrin Kras Prkca Hras Nras Egfr Hbegf Sos1 Grb2 GENE SILENCING BY RNA%REACTOME DATABASE ID RELEASE 66%10145435 Gene Silencing by RNA Nup93 Nup43 Nup98 Nup133 Nup107 Aaas RGD1306195 RGD1565904 Nup210 Npap60 Polr2g Polr2h Nup35 Polr2e Polr2f Tnrc6b Nup37 Polr2j Polr2k Polr2d Nupl2 Tnrc6a Polr2i Tnrc6c Polr2b Polr2c Nupl1 Polr2a Hist1h2bo Hist1h2bcl1 Hist2h3c2 LOC100912534 Hist1h2bk H3f3b Nup205 Ranbp2 LOC100910200 H2afx Hist1h4b LOC684841 Hist1h2bh LOC100912290 Nup155 Hist1h2ail1 Hist1h4m LOC102549173 LOC103690002 LOC100910152 LOC100912338 Hist1h3c H2afb3 Hist1h3f Nup88 Hist2h4 LOC684819 Hist1h3a H2afj LOC100911822 Hist2h2aa3 Hist1h2bq Hist2h2aa2 Nup85 LOC100364835 LOC684762 Nup153 Prkra Ago3 Dicer1 Tsnax Ago4 Ago2 Tpr Rae1 Tsn Tarbp2 Nup54 Pom121 Hist1h2bg LOC680097 Nup62 LOC684797 LOC100912418 Hist1h2ba Hist3h2bb RUNX1 REGULATES GENES INVOLVED IN MEGAKARYOCYTE DIFFERENTIATION AND PLATELET FUNCTION%REACTOME%R-RNO-8936459.1 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function LOC100911167 Prmt6 Gata1 Hist1h2bo Hist1h2bcl1 Hist2h3c2 Hist1h2bk H3f3b Hdac1l Prmt1 LOC100911617 Cbfb Rbbp5 Runx1 LOC100910200 H2afx Hist1h4b Wdr5 Kmt2a LOC684841 Hist1h2bh LOC100912290 Hist1h2ail1 Zfpm1 Hist1h4m LOC102549173 LOC103690002 LOC100910152 LOC100912338 Hdac1 Hist1h3c H2afb3 Hist1h3f Hist2h4 LOC684819 Hist1h3a H2afj Hist2h2aa3 Hist1h2bq Hist2h2aa2 Ash2l LOC100364835 Dpy30 LOC684762 Sin3a Sin3b Hist1h2bg LOC680097 LOC684797 LOC100912418 Hist1h2ba Hist3h2bb ONCOGENE INDUCED SENESCENCE%REACTOME DATABASE ID RELEASE 66%10145265 Oncogene Induced Senescence Cdkn2b Ets1 Mdm2 Erf Ets2 LOC100910954 Mdm4 Cdkn2c Id1 Cdk4 Cdk6 Mapk1 BIOSYNTHESIS OF MARESIN CONJUGATES IN TISSUE REGENERATION (MCTR)%REACTOME DATABASE ID RELEASE 66%10146313 Biosynthesis of maresin conjugates in tissue regeneration (MCTR) Ltc4s Gstm4 ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS%REACTOME DATABASE ID RELEASE 66%10145721 Acetylcholine binding and downstream events Chrnb4 Chrne Chrnd Chrna4 Chrna5 Chrna9 Chrna6 Chrnb2 Chrna7 Chrnb3 Chrna2 Chrna3 Chrna1 LIPID PARTICLE ORGANIZATION%REACTOME%R-RNO-8964572.1 Lipid particle organization Fitm1 Fitm2 Cidec Hsd17b13 TYPE I HEMIDESMOSOME ASSEMBLY%REACTOME DATABASE ID RELEASE 66%10145647 Type I hemidesmosome assembly Cd151 Lamc2 LOC100911730 Itgb4 Dst Itga6 Plec Lamb3 Col17a1 METABOLISM OF INGESTED MESEO2H INTO MESEH%REACTOME%R-RNO-5263617.1 Metabolism of ingested MeSeO2H into MeSeH Txnrd1 PROTEIN METHYLATION%REACTOME%R-RNO-8876725.1 Protein methylation Prmt3 Mettl21a Mettl20 Mettl22 Eef2kmt Etfb Eef2 Kin LOC102553119 Rps2 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE%REACTOME DATABASE ID RELEASE 66%10145901 Synthesis of PIPs at the Golgi membrane Pi4k2a Pik3c3 Tpte2 Fig4 Pik3r4 Pi4kb Inpp5e Vac14 Pikfyve Pik3c2a Ocrl Sacm1l Pi4k2b Pik3c2g LAMININ INTERACTIONS%REACTOME DATABASE ID RELEASE 66%10145448 Laminin interactions Col18a1 Itga3 Nid1 Nid2 Lama4 Lamc1 Lamc2 Itgb4 Itga6 Lamb1 Itga7 Lamb2 Lama1 Lamb3 SMAC BINDS TO IAPS%REACTOME%R-RNO-111463.1 SMAC binds to IAPs Diablo LOC100360940 Xiap NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING%REACTOME%R-RNO-936440.1 Negative regulators of RIG-I MDA5 signaling Ddx58 Tbk1 LOC364561 Pin1 Tax1bp1 Mavs Irf3 Cyld Ikbke Tnfaip3 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM%REACTOME DATABASE ID RELEASE 66%10145731 Heparan sulfate heparin (HS-GAG) metabolism Ncan Agrn Xylt2 Dcn B3gat1 B3gat3 B3gat2 Hs6st2 LOC102550316 Cspg5 Cspg4 Sdc2 Hs6st1 Sdc3 Idua Sdc4 Gpc6 Bcan Vcan Hs3st3a1 Gpc4 Gpc2 Ndst1 Glb1l Ndst2 LOC100910284 Ndst3 Ndst4 Ext1 Ext2 Slc35d2 Glb1 Gusb B4galt7 Hpse Hs3st3b1 Hs2st1 Hs3st5 Naglu Gpc1 Hs3st2 Hs3st1 B3galt6 Hs3st6 APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS%REACTOME DATABASE ID RELEASE 66%10145386 Apoptotic cleavage of cell adhesion proteins Casp3 Dsg3 Dsg2 Ocln Tjp2 Pkp1 Cdh1 Dsp Dsg1 ASPARAGINE N-LINKED GLYCOSYLATION%REACTOME%R-RNO-446203.1 Asparagine N-linked glycosylation Mgat2 Mgat5 Sec24a Sec24b Dync1li2 Copa Sec24d Mgat3 Mgat1 Dync1i2 Man1c1 Man1a1 Cog4 Cog6 Cog8 Cog3 Cog1 Cog2 Sec23ip Lman1l Cog7 LOC102555167 Dynll2 Dync1i1 Ykt6 Sec24c Tmed7 Fuom Slc35c1 Tmed3 Tmed2 Napg Napb Fuk Napa Tsta3 Gmds LOC100911225 Fpgt Tmed9 Nsf Edem3 Calr Man1b1 Rnf139 Ganab Edem2 Uggt1 Trim13 Rnf5 Ngly1 Prkcsh Arcn1 Glb1 St3gal2 St3gal3 St3gal1 St3gal4 St3gal6 Trappc10 Canx Rnf103 Ppp6c Manea March6 Trappc2l Cd59 Ctsa Engase Trappc6a Trappc6b B4galt1 Ankrd28 Sec13 B4galt3 Sar1b B4galt2 B4galt6 B4galt4 B4galt5 Rab1b Rab1a Tmem115 Arfgap2 Ank1 Ctsc Golgb1 Arfgap3 Ctsz Mlec Arfgap1 Ubxn1 Spta1 Mcfd2 Preb Chst10 Capzb Nans Sptbn1 Rad23b Npl Sec31a Dhdds Cmas Stx17 Nanp Gosr2 Gosr1 Tmed10 Areg Stx5 Bet1 Arf5 Cnih1 Arf4 Lhb Ctage5 Asgr1 Gbf1 Cnih3 Cnih2 Asgr2 Tgfa Derl1 Man2a1 Fut8 Man2a2 Mgat4b Mgat4a Mvd Copz2 Copz1 Col7a1 F8 Lman2 Scfd1 Sec16a Sec16b Lman1 Cga Trappc2 Trappc5 Copb1 Chst8 Tfg Neu4 Neu2 Neu3 Neu1 Trappc3 LOC100910318 Kdelr1 Srd5a3 Tbc1d20 Capza2 Capza3 Kdelr2 Ppp6r3 Trappc1 Ppp6r1 Kdelr3 LOC100910557 Sptan1 Vcp Actr10 Dync1h1 Dync1li1 Copg1 Dctn5 Dctn6 Ins1 Ins2 Dctn4 Folr1 Dctn1 Dctn2 Uso1 Gorasp1 Dctn3 St8sia1 Alg1 Gfpt2 Nus1 Alg2 Dolpp1 Gfpt1 St8sia3 Alg6 Os9 Alg3 Alg9 Alg8 Renbp St3gal5 Mpi Pgm3 Pmm2 Alg14 Pmm1 Alg12 Sec22b Slc35a1 Cope St8sia5 Slc17a5 Sec23a St6galnac1 St6galnac2 Nudt14 LOC501189 St8sia4 Sec22a LOC100910177 Csnk1d Dolk St6gal1 St6gal2 Amdhd2 Psmc1 St6galnac4 St6galnac3 Nagk Gne Mpdu1 Man1a2 Dpagt1 St6galnac6 Gnpnat1 Dpm3 Actr1a Dpm2 LOC100363782 Dpm1 Sel1l Uap1 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE)%REACTOME%R-RNO-140877.1 Formation of Fibrin Clot (Clotting Cascade) F13a1 Pf4 Cd177 Klkb1 Kng1 F12 F11 Serpina5 Kng2 C1qbp LOC100909700 A2m Serpine2 Serpind1 Serping1 Tfpi Vwf F3 Fgb Fgg Kng1l1 Gp1ba Gp9 Serpinc1 Pros1 Gp5 Thbd Gp1bb F13b Fga LOC100911551 Procr Prcp F2r F2 F8 F7 F9 CD28 DEPENDENT PI3K AKT SIGNALING%REACTOME%R-RNO-389357.1 CD28 dependent PI3K Akt signaling Mtor Cd80 Cd86 Fyn Pik3r3 Pik3r1 Map3k8 Pik3r2 Mlst8 Trib3 Pdpk1 Akt1 Mapkap1 Cd28 Akt3 Map3k14 Them4 Akt2 Rictor TYSND1 CLEAVES PEROXISOMAL PROTEINS%REACTOME DATABASE ID RELEASE 66%10146324 TYSND1 cleaves peroxisomal proteins Tysnd1 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX%REACTOME%R-RNO-141430.1 Inactivation of APC C via direct inhibition of the APC C complex Anapc7 Cdc26 Cdc27 Cdc23 Ube2c Bub3 Ube2d1 Anapc16 Cdc16 Cdc20 Anapc4 Anapc2 Anapc1 Bub1b Anapc11 Anapc15 Mad2l1 Anapc10 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION%REACTOME%R-RNO-162658.1 Golgi Cisternae Pericentriolar Stack Reorganization Gorasp2 Rab2a Rab1b Rab1a Gorasp1 Blzf1 LOC100363782 LOC102555167 Mapk1 LYSOSOME VESICLE BIOGENESIS%REACTOME%R-RNO-432720.1 Lysosome Vesicle Biogenesis Ap4e1 LOC100909548 Ap4b1 Ap1g2 Ctsz Clvs1 Chmp2a Cltc Cltb Ap1m1 Clta App Dnm2 Vamp2 Ap1m2 Txndc5 Ap4m1 Bloc1s1 Dnase2 Ap4s1 Ap1b1 Vamp8 Arrb1 Sh3gl2 Ap1s3 M6pr Ap1s1 Ap1s2 Vamp7 PD-1 SIGNALING%REACTOME%R-RNO-389948.1 PD-1 signaling Cd247 Csk Pdcd1lg2 Pdcd1 Cd3g Cd274 LOC100911478 Ptpn11 Cd3e RT1-Ba Cd3d RT1-Bb Ptpn6 RT1-Da RT1-Db2 Cd4 RT1-Db1 LOC688090 TRANSPORT OF BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS%REACTOME%R-RNO-425366.1 Transport of bile salts and organic acids, metal ions and amine compounds Slc6a11 Slc6a13 Slc11a1 Slc6a1 Slc6a12 Rhag Slc44a4 Slc11a2 Slc44a5 Slc44a3 Rhcg Slc6a2 Heph Slc14a1 Slc18a1 Slc30a10 Slc22a15 Slc16a3 Slc6a7 Slc16a7 Slc6a9 Slc16a8 Slc16a1 Slc6a6 Slc22a5 Slc6a5 Slc39a2 Slc39a3 Slc39a4 Slc39a6 Slc44a2 Slc22a6 Slc22a3 LOC100911874 Slc22a7 Slc39a7 Slc22a1 Slc39a8 Slc22a2 Slc47a1 Slc6a3 Slc5a11 Runx1 Slc2a13 Slc30a5 Slc30a6 Slc30a8 Slc39a14 Bsg Slc31a1 Slc30a1 Slc6a15 Slc6a14 Slc6a19 Slc6a18 Slc6a20 Slc10a6 Slc13a4 Slc41a1 Slc41a2 Slc40a1 Slc13a1 Slc13a2 Slc13a3 Slc5a7 Cp SIGNALLING TO RAS%REACTOME DATABASE ID RELEASE 66%10145202 Signalling to RAS Shc3 Kras Shc2 Mapkapk3 Mapkapk2 Ralgds Hras Nras Sos1 Mapk14 Mapk11 Shc1 Grb2 ACTIVATION OF NF-KAPPAB IN B CELLS%REACTOME%R-RNO-1169091.1 Activation of NF-kappaB in B cells Psmc6 Psmb10 Psmb8 Psmb9 Psmb4 Psmb11 Nfkbib Psmb5 Psmf1 Psmb6 Psmd4 Cul1 Psmb2 Psmd5 Psmd8 Psmd9 Psmb3 Psma8 Psmd11 Psmd12 Psmd13 Rela Psmd14 Psmc3 Nfkbia G6pc Psmb7 Psmb1 Skp1 Prkcb Nfkbie Nfkb1 Psma5 Fbxw11 Chuk Btrc Psma2 Psmc5 Psmd2 Psma1 Psma4 Psmc1 Psma3 Psmc4 Psmc2 Psma6 Psme1 Psmd1 Psme2 Psmd7 Ikbkb Psmd3 Psmd6 NUCLEOSOME ASSEMBLY%REACTOME%R-RNO-774815.1 Nucleosome assembly Cenpn LOC100910200 Cenpl H2afx Cenpo Hist1h4b Mis18bp1 Hist1h2bh Cenpt Cenpu LOC100912290 Rbbp7 Hist1h4m LOC103690002 LOC100910152 LOC100912338 H2afb3 Cenpk Hist2h4 Cenph Cenpi Hjurp H2afj Hist2h2aa3 Hist1h2bq Hist2h2aa2 Cenpm Casc5 LOC100364835 Hist1h2bo Hist1h2bcl1 Hist1h2bk Cenpc Cenpa Cenpw Hist1h2bg Ruvbl1 LOC100911204 Smarca5 LOC680097 LOC684797 LOC100912418 Hist1h2ba Hist3h2bb Itgb3bp DDX58 IFIH1-MEDIATED INDUCTION OF INTERFERON-ALPHA BETA%REACTOME%R-RNO-168928.1 DDX58 IFIH1-mediated induction of interferon-alpha beta Tbk1 Ager Irf3 Cyld Nfkbib Ddx58 App LOC364561 Pin1 Tax1bp1 Mavs Rela Tnfaip3 Nfkb2 Nfkb1 S100b Dhx9 Chuk Ikbke Dhx36 Nkiras1 Nfkbia Nkiras2 Ikbkb Crebbp Myd88 EGFR DOWNREGULATION%REACTOME DATABASE ID RELEASE 66%10145266 EGFR downregulation Arhgef7 Eps15l1 Ptpn3 Egfr Spry2 Cbl Cdc42 Stam2 Sh3gl2 Sh3gl1 Sh3kbp1 Ptprk Spry1 Sh3gl3 Ptpn12 Stam Grb2 INTERLEUKIN-1 FAMILY SIGNALING%REACTOME DATABASE ID RELEASE 66%10145170 Interleukin-1 family signaling Psmc6 Psmb10 Psmb8 Psmb9 Psmb4 Psmb11 Psmb5 Psmf1 Psmb6 Psmd4 Psmb2 Rbx1 Psmd5 Psmd8 Psmd9 Psmb3 Psma8 Psmd11 Psmd12 Psmd13 Psmd14 Il1rl2 Il36rn Il1f10 Il1rap Il36b Il36a Psmc3 Sqstm1 Il1b Ube2n Il1rl1 Skp1 Nfkb2 Nfkb1 Mapk8 S100b Irak4 Dhx9 Fbxw11 Chuk Btrc Nkiras1 LOC100362142 Nod1 Nod2 Nkiras2 Tab2 Tab3 LOC100912618 Ube2v1 Ikbkb Myd88 Tnip2 Ripk2 Tbk1 Map2k6 Ager Map3k8 Peli3 Nfkbib Stat3 Peli2 Traf6 Cul1 App Il33 Tab1 Rela Map3k7 Peli1 Irak2 Nfkbia LOC100910771 Irak3 Il1r1 Il1rapl1 Map3k3 G6pc Il18r1 Psmb7 Psmb1 Il18 Il1a Casp1 Psma5 Tollip Psma2 Psmc5 Psma1 Psmd2 Psma4 Psmc1 Psma3 Psmc4 Psma6 Psmc2 Psme1 Psmd1 Psme2 Psmd7 Psmd3 Psmd6 SUMOYLATION OF INTRACELLULAR RECEPTORS%REACTOME%R-RNO-4090294.1 SUMOylation of intracellular receptors Nr1h4 Nr5a2 Nr1h3 Nr1h2 Sumo1 Pias3 Pias1 Sumo3 Nr5a1 Rxra Rora Nr1i2 Esr1 Ppara Hdac4 Pias4 Ube2i Pias2 Pgr Thra Thrb RUNX3 REGULATES P14-ARF%REACTOME DATABASE ID RELEASE 66%10146279 RUNX3 regulates p14-ARF Brd2 Kras Cbfb Ccnd1 Hdac4 Tgfb1 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS%REACTOME DATABASE ID RELEASE 66%10145174 ZBP1(DAI) mediated induction of type I IFNs Nfkb2 Nfkb1 Ager Irf3 S100b Dhx9 Nfkbib Chuk Nkiras1 App Nfkbia Nkiras2 Rela Ikbkb Myd88 PROTON OLIGOPEPTIDE COTRANSPORTERS%REACTOME DATABASE ID RELEASE 66%10145629 Proton oligopeptide cotransporters Slc15a1 Slc15a3 METALLOPROTEASE DUBS%REACTOME DATABASE ID RELEASE 66%10146145 Metalloprotease DUBs Bard1 Hist1h2aa Nlrp3 Fam175a Hist2h2ab Mysm1 Babam1 Bre Brca1 Brcc3 Stambp Stambpl1 Fam175b Hist2h2aa3 Hist2h2aa2 Psmd14 Uimc1 Stam ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION%REACTOME%R-RNO-450302.1 activated TAK1 mediates p38 MAPK activation Ripk2 Map2k6 Mapkapk3 Traf6 Mapkapk2 LOC100362142 Nod1 Nod2 LOC100910771 Tab2 Ube2n Tab3 Tab1 LOC100912618 Ube2v1 Mapk14 Map3k7 Mapk11 Irak2 NEGATIVE FEEDBACK REGULATION OF MAPK PATHWAY%REACTOME%R-RNO-5674499.1 Negative feedback regulation of MAPK pathway Raf1 Map2k2 Mapk1 ALPHA-OXIDATION OF PHYTANATE%REACTOME DATABASE ID RELEASE 66%10145549 Alpha-oxidation of phytanate Phyh Slc25a17 Aldh3a2 Slc27a2 Hacl1 LIGAND-DEPENDENT CASPASE ACTIVATION%REACTOME DATABASE ID RELEASE 66%10144860 Ligand-dependent caspase activation Faslg Traf2 Cflar Fadd Ripk1 Tradd Tnfsf10 Casp8 Fas PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE%REACTOME DATABASE ID RELEASE 66%10144782 Pyruvate metabolism and Citric Acid (TCA) cycle Mdh2 Idh3g Glo1 Idh2 Rxra Cs Sucla2 Ppard Slc16a3 Slc16a8 Slc16a1 Ldha Vdac1 Ldhb Me2 Hagh Fahd1 Me3 Sdhc Sdhd Sdha Me1 Dlst Sdhb Ogdh Bsg Pdpr Pdhb Pdk3 Pdk4 Pdk1 Pdk2 LOC100365902 Pdha2 Pdha1 Pdhx Pdha1l1 Suclg2 Ldhc Nnt Idh3a Gstz1 D2hgdh Pdp1 Aco2 Adhfe1 Idh3B Dlat L2hgdh Fh Dld CD28 DEPENDENT VAV1 PATHWAY%REACTOME DATABASE ID RELEASE 66%10145542 CD28 dependent Vav1 pathway Cd80 Cd86 Fyn Pak2 Pak3 Pak1 Vav1 Rac1 Grb2 Cd28 Cdc42 AMINE LIGAND-BINDING RECEPTORS%REACTOME%R-RNO-375280.1 Amine ligand-binding receptors Htr2c Adra1a Htr2a Htr2b Adra1d Chrm2 Chrm4 Taar9 Adra2a Hrh2 Htr5a Taar6 Htr4 Adra2c Adra2b Taar5 Taar2 Gpr143 Adrb3 Htr1d Htr1f Htr1a Hrh1 Htr1b Htr7 Hrh4 Chrm1 Chrm5 Drd5 Drd1 Drd4 Adrb2 Drd2 Chrm3 Htr6 MRNA DECAY BY 5' TO 3' EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 66%10145636 mRNA decay by 5' to 3' exoribonuclease LOC100360750 Lsm7 Lsm6 Lsm4 Lsm3 Lsm5 Dcp2 Lsm2 Dcp1a Lsm1 LOC679753 Patl1 Edc3 Edc4 Dcp1b MOLYBDENUM COFACTOR BIOSYNTHESIS%REACTOME%R-RNO-947581.1 Molybdenum cofactor biosynthesis Mocs1 LOC100911034 Mocs3 Mocos Nfs1 TRANSLESION SYNTHESIS BY Y FAMILY DNA POLYMERASES BYPASSES LESIONS ON DNA TEMPLATE%REACTOME DATABASE ID RELEASE 66%10144977 Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template Rfc1 Rfc2 Pole2 Pole4 Polh Vcp Ns5atp9 Poli Uba7 Usp43 Rev1 Rpa1 Rpa2 Ube2l6 Rchy1 Rpa3 Pole Pold2 Pcna Pold1 Pold4 Isg15 Trim25 Sprtn Nploc4 Usp10 Mad2l2 Rfc5 Rev3l Rfc4 Ufd1l Rfc3 HISTIDINE, LYSINE, PHENYLALANINE, TYROSINE, PROLINE AND TRYPTOPHAN CATABOLISM%REACTOME DATABASE ID RELEASE 66%10144795 Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism Ogdh Fah Tat Slc7a5 Pcbd1 Hpd Phykpl Kmo Kynu Ccbl1 Ido1 Hgd Il4i1 Pah Slc36a4 Asrgl1 Tdo2 Qdpr Amdhd1 Carns1 Hnmt Hal Gstz1 Hdc Ftcd Uroc1 Tas1r2 Aldh4a1 Pipox LOC100910122 Aldh7a1 Gcdh Aadat Dlst Prodh Iffo2 Hykk Dld SPERM MOTILITY AND TAXES%REACTOME%R-RNO-1300642.1 Sperm Motility And Taxes Catsper4 Kcnu1 Hvcn1 Catsper3 Catsper2 ENZYMATIC DEGRADATION OF DOPAMINE BY COMT%REACTOME DATABASE ID RELEASE 66%10145520 Enzymatic degradation of dopamine by COMT Maoa Comt Lrtomt REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE%REACTOME%R-RNO-176408.1 Regulation of APC C activators between G1 S and early anaphase Psmc6 Psmb10 Psmb8 Psmb9 Psmb4 Psmb11 Bub3 Psmb5 Psmf1 Psmb6 Psmd4 Psmb2 Cul1 Psmd5 Psmd8 Psmd9 Psmb3 Psma8 Psmd11 Psmd12 Ccna2 Anapc11 Ccna1 Anapc15 Psmd13 Psmd14 Anapc10 Fzr1 Fbxo5 Cdk2 Psmc3 G6pc Ube2d1 Cdc20 Psmb7 Psmb1 Bub1b Skp1 Mad2l1 Anapc7 Cdc26 Cdc27 Cdc23 Psma5 Ube2c Cdkn1a Cdkn1b Cdk1 Anapc16 Cdc16 Btrc Anapc4 Psma2 Anapc2 Anapc1 Psmc5 Psmd2 Psma1 Psma4 Psmc1 Psma3 Psmc4 Psmc2 Psma6 Psme1 Psmd1 Psme2 Psmd7 Psmd3 Psmd6 RNA POLYMERASE III TRANSCRIPTION%REACTOME%R-RNO-74158.1 RNA Polymerase III Transcription Bdp1 Polr3d Snapc3 Snapc4 Polr3c Polr3a Polr3e Polr3b RGD1565904 Polr3h Polr2h Polr3k Polr2e Polr2f Polr1c Polr3g Polr2k Polr3f Gtf3c6 Gtf3c5 LOC100912534 Gtf3c1 Gtf3c3 Gtf3c4 Polr3gl Brf1 Brf2 Pou2f1 Gtf3a Snapc5 Snapc2 Tbp ACTIVATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME DATABASE ID RELEASE 66%10144871 Activation of the phototransduction cascade Gnat1 Cngb1 Cnga1 Pde6b Gnb1 Gngt1 Pde6a Pde6g FERTILIZATION%REACTOME%R-RNO-1187000.1 Fertilization Kcnu1 Cd9 Catsper3 Catsper2 Izumo3 Izumo1 Catsper4 LOC100911976 Spam1 Acr Izumo4 Izumo2 Hyal5 Hvcn1 SIGNAL AMPLIFICATION%REACTOME%R-RNO-392518.1 Signal amplification Gnai3 Src P2ry1 Tbxa2r Gnaq Gna11 Gna14 Gna15 Gnat3 Pla2g4a Gna13 P2ry12 Gnai2 Gnb3 Gnb5 Gnb2 Gnb1 Gng13 Gng12 Gng11 LOC100912034 Gnb4 Gng4 Gngt2 Mapk14 Gnai1 Gng5 Gngt1 Gng10 Gng8 Gng3 ACTIVATED PKN1 STIMULATES TRANSCRIPTION OF AR (ANDROGEN RECEPTOR) REGULATED GENES KLK2 AND KLK3%REACTOME DATABASE ID RELEASE 66%10146086 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 LOC100910200 H2afx Hist1h4b LOC684841 Hist1h2bh LOC100912290 Hist1h2ail1 Hist1h4m LOC102549173 LOC103690002 LOC100910152 LOC100912338 Hist1h3c H2afb3 Hist1h3f Hist2h4 LOC684819 Hist1h3a H2afj Hist2h2aa3 Hist1h2bq Kdm1a Hist2h2aa2 LOC100364835 LOC684762 Hist1h2bo Hist1h2bcl1 Hist2h3c2 Pkn1 Hist1h2bk H3f3b Ncoa2 Hist1h2bg LOC680097 LOC684797 LOC100912418 Hist1h2ba Hist3h2bb PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE%REACTOME%R-RNO-174414.1 Processive synthesis on the C-strand of the telomere Rpa1 Slc25a16 Rpa3 Fen1 Rpa2 LOC100911727 Pold2 Pcna Pold1 Lig1 Pold4 IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 66%10145133 Immune System Kif3c Racgap1 Kif22 Kif3b Kif23 Stim1 Pias1 Kifap3 Myo1c Kif11 Ppie Kif4a Rbx1 Actb Sumo1 Pld4 Ube2v2 Ube2n Atox1 Brwd1 Akt1 Tlr7 Cd101 Tlr8 Irak4 Myo10 Eea1 Stx1a Kif26a Kif20a Map2k7 Nlrp4 Ripk2 Dtx4 Map2k6 Tbk1 Ager Ddx41 Dusp3 Nlrp4a Map2k4 Irf3 Trim21 Map3k8 Trim32 Dusp4 Peli3 Nfkbib LOC100912399 Peli2 Map3k1 Traf6 Cul1 Vrk3 Commd9 Rps6ka2 Rps6ka1 Pdxk App Cd53 Atg7 Rps6ka3 Xrcc6 Rps6ka5 Bpi Tirap Hbb-b1 LOC100912585 Xrcc5 Tab1 Dusp7 Dusp6 Rela Atf1 Atf2 Map3k7 Peli1 Irak2 Cd59 Np4 Ctsa Ptprc Cyfip1 Serpinb3a Cd63 Pnp Sdcbp RGD1304587 Cct2 Apaf1 LOC100909857 Ddost LOC498300 Vamp8 Defa7 Gdi2 Ptpn2 Anpep Plaur Serpinb12 Nfkbia Sh3gl2 Cct8 LOC100910771 Defa5 Sh3kbp1 Cst3 Dnajc13 Nckap1l Serpinb10 LOC100909879 Ilf2 Qsox1 Mpo Fcgr3a LOC685953 C1s Slc2a5 C1r Masp2 Cd36 Ctsc C1qb Colec10 Rock1 C4a Rap2b C1qa Syngr1 C4b Tmem179b Svip Serpinb1b Ctsz Mlec Arg1 LOC100909666 Frk Gzmm Serpinb1a LOC102549354 C2 Cstb Psmb7 Psmb1 Vapa Lrrc7 Prdx4 Gmfg C5ar1 Nme2 LOC687609 Dsn1 Lrmp Rap2c Grn Stom Dsp Cab39 Cd14 LOC100909700 Atp6v0a1 Ltf Psma5 Slpi Padi2 Plekho2 Rap1a Fcer1g Tollip Gsn Pkp1 Chi3l1 Psma2 Pglyrp1 Snap29 Psmd2 Commd3 Idh1 Bst1 Ptpn6 Psmc2 Fgl2 Tnfaip6 Psmd1 Psmd7 Iqgap1 Prdx6 Ppl Tspan14 Psmd3 Psmd6 Sh2b1 Ptpn1 Fbxl19 Gh1 Ghr Fbxl12 Fbxl13 Fbxl16 Fbxl15 Prl Csf1 Colec11 Ube2z Ube2s Fbxl4 Fbxl5 Fbxl8 Lbp Ptpn4 Jun Cd3e RT1-Ba Ppp2cb RT1-Bb Ppp2ca RT1-Da Skp1 RT1-Db2 Ppp2r1a RT1-Db1 LOC688090 Nfkb2 Nfkb1 Mapk9 Mapk8 Fos S100b Mapk7 Dhx9 Fbxw11 Chuk Ppp2r1b Ecsit Eif4a3 Mapkapk3 Btrc Mapkapk2 Mapk1 Nkiras1 LOC100362142 Nod1 Nod2 Nkiras2 Creb1 Tab2 Tab3 LOC100912618 Ube2v1 Ikbkb Mapk14 Myd88 Tnip2 Mapk11 Mapk10 Stat5a Jak3 Il22 Il24 Il19 Stat1 Il22ra1 Jak1 Stat2 Stat3 Il10rb Hsp90b1 Colec12 Ap1m2 Hist2h3c2 Smarca4 Eif4g2 Eif4g3 Flnb Isg15 Trim25 Eif2ak2 Ppm1b Eif4e3 Mx1 Il22ra2 Mx2 Il20ra Il20rb Tyk2 Ifnl3 Il20 Ifnlr1 LOC684841 Eif4e2 Arih1 Hist1h2ail1 LOC102549173 RT1-DMa RT1-DMb Hist1h3c Cd74 Lag3 Hist1h3f Rilp LOC684819 Hist1h3a Ifi30 LOC100909593 LOC100909630 RT1-DOb RT1-DOa Ctse Ctsf LOC684762 RGD1560225 Ppp3ca Nfatc2 Tec Txk Lat Plcg1 Nfatc3 Lcp2 Itk Sec24a Sec24b Sec24d Pde12 Oasl Asb18 Rnasel Abce1 Asb11 Asb12 Asb13 Cnpy3 Asb14 Unc93b1 Asb10 Tlr3 Keap1 Vamp2 Asb15 Asb17 Asb16 Ddx3x Plac8 RGD1563818 Cotl1 Cmtm6 RT1-A2 Lpcat1 RT1-A1 Ggh Clec5a B2m LOC100125364 Glipr1 Rnaset2 Ap1b1 Gpr84 RGD1561778 Ist1 Cpped1 Cand1 A1bg Stx4 Clec4d Sec24c LOC100911393 Pdzd11 Ptpn22 Anapc7 Cdc26 Cdc27 Cdc23 Fbxl22 Lrrc41 Ube2c Crk Skp2 Fbxw10 Cdc16 Fbxw12 Anapc4 Anapc2 Anapc1 Ifnar2 Ifna5 Traf2 Ifna4 LOC100912356 LOC100911527 Ifna11 LOC100912859 Ifnar1 RGD1560539 Ifna2 Ap1s3 Ifnb1 Ap1s1 LOC103690314 Ap1s2 LOC100912314 Ifna16l1 RGD1565911 RGD1561827 Il33 Anapc11 Anapc10 Fzr1 Usp18 Irf9 Tnfsf13b Tnfrsf9 Tnfrsf8 Edaradd Tnfrsf4 Eda2r Ifngr2 Klhl5 Ifngr1 Cd70 Tnfrsf17 Tnfsf8 Tnfsf9 Tnfrsf25 Edar Prmt2 Tnfrsf11b Tnfrsf11a Tnfsf4 Tnfsf14 Tnfsf12 Tnfrsf12a Tnfrsf13c Eda Tnfsf11 Capzb Lta Klhl2 Ltb Ltbr Fbxo2 Il9r Il15 Cd27 Ifng Il9 Fbxo9 Fbxo7 Fbxo6 Fbxo4 Ube2k Ube2h Ube2f Sec31a Ube2a Il10ra Il10 Klhl9 Lrr1 LOC100912571 Atp6v1d Cda Lamp1 Ftl1 Psap RatNP-3b Svs1 Fuca2 Rnf123 Serpinb6b Igf2r Lrg1 RGD1306474 Magt1 Rac1 Acly Cap1 Bpifb2 Pdap1 Doxl2 Doxl1 Cpne3 Rnase17 Rab27a Ccnf Psmd11 Psmd12 Ube2e3 Fabp5 Dynlt1 Psmd13 Psmd14 Eif4g1 Tmem30a Lamp2 Unc13d Rictor Mif Ap2a2 Crisp3 Cfp S100a11 Aga Cfd RT1-M3-1 Serpinb3 Atp8a1 Kcmf1 Tceb2 Tceb1 Aldh3b1 Cul2 Ndufc2 Serpinb6 Aprt Faf2 Cpne1 Psmc3 Diaph1 Trpm2 LOC100364500 Defa11 Fcnb Defa10 RT1-S3 Bcl10 Eif4a2 Cant1 Tmem173 Cxcr2 Atp6v0c Eif4a1 RGD1564463 Rbsn LOC680559 Anxa2 Mgst1 Retn RT1-CE2 Kctd7 Dpp7 Nit2 RT1-CE3 Src RT1-CE4 Rnf7 RT1-CE7 RT1-CE5 Slco4c1 Hsp90ab1 RGD1561661 Rab3a Copb1 Cat Cd177 RT1-CE10 Hebp2 Cltc Rab7a Ptges2 Ptafr Clta Tubb5 Creg1 Pigr Mettl7a Alox5 Prkcb Kbtbd8 Kcnab2 Ywhaz Ap2s1 Pygb Ppp3r1 Bcl2 Rab4b Kbtbd7 Ticam2 Kbtbd6 Mme Ywhab Ap2a1 Neu1 Lta4h Kctd6 Ms4a3 Ap2m1 Cxcl2 Cxcl1 Epx Ube2q2 S100a8 Cd68 Ube2r2 Rab5b Cxcl3 Rab5c Chit1 Ampd3 Hspa5 Slc27a2 Capza2 Capza3 Dgat1 Rab6a LOC683761 LOC100364956 Gan Atp6ap2 Tmem63a Ptprn2 Nhlrc3 Naprt1 Ano6 Pa2g4 Gm2a Dbnl Fcgr2b LOC103693683 Atad3a Serpina3m Rab9b Fcgr2a Trappc1 Tnfsf13 Tlr2 Plau Slc11a1 PVR Kpnb1 Chrnb4 Fpr1 Arl8a Pld1 Ostf1 Ear1 Cd40 Vcl Cd34 Prg3 Siglec1 Mill1 Erp44 LOC680910 Stk10 Sptan1 LOC685157 Vcp Cd200 Prg2 Hcst Asb5 Rab18 Cd300lb Ghdc Asb6 Siglec15 Cd300le Asb7 LOC100910990 Kir3dl1 Slpil3 Pianp Cd300e Klhl41 Rab10 Asb1 Rab14 Cd300lg Asb3 Cd1d1 Slpil2 Vnn1 Cdc34 Cd300lf Crtam Asb8 Rab24 Actr10 LOC685048 Nbeal2 RGD1559588 Klhl42 Lamtor3 Sh2d1b2 RT1-A Pilra Arsa Cd22 RGD1566006 Tmbim1 Dok3 LOC685438 Tnfaip3 Dync1h1 P2rx1 Acaa1a Acaa1b Lamtor2 Lamtor1 Apeh Ypel5 Dync1li1 Fbxo41 Slc44a2 LOC103692716 Qpct Fbxo44 Fbxo40 RGD1565355 Cybb Cyba LOC361635 Wsb1 Actr1b Dctn5 RT1-M2 Hmha1 Dctn6 Lgals3 Spsb2 RT1-M5 Spsb1 RT1-M4 Nfam1 Ubr4 Crispld2 Pycard Crebbp Stk11ip Dctn4 Rab3d Rbm12 Spsb4 Galns Gca C3ar1 Btbd1 Btbd6 Prkcd Fbxo22 Armc8 Ube2g2 Olfm4 Kras Ube2g1 Fcar Gstp1 Asah1 Mnda Pik3r1 Il6 Bri3 Pik3r2 Klhl13 Ptx3 Srp14 Fbxo30 Pdcd1lg2 Tcirg1 Fbxo31 Hmox2 Ptprj Klhl11 Tnfrsf14 Jup Fbxo32 Btla Icoslg Fbxo21 Mospd2 Impdh1 Cd28 Impdh2 Pdcd1 Ddx58 Ap1m1 Cd274 Klhl20 LOC100911478 Nfasc Icos Rnase3 LOC100360575 Rnase2 Enpp4 Sirpa LOC100911431 Tyrobp LOC100360087 Cdk13 Zbtb16 LOC299277 Klhl25 Golga7 Klhl21 Hvcn1 Uba1 Stbd1 Klhl22 Dsg1 Txndc5 Fbxo10 Dnajc5 Csnk2b Actr2 Fgr Alad Fbxo15 Gla Dnajc3 Fbxo11 Tnfrsf1b Sec22b Arhgap9 RGD1559482 Sec23a C3 Fbxw2 RT1-M6-1 Uba6 Rnf34 Lair1 Ppbp Mapkap1 Atp11a Vat1 Aoc1 Pik3cb Fbxw9 Uba3 Map3k14 RT1-M6-2 Ptpn11 Agpat2 Relb Rhoa Fbxw5 Eef2 Fbxw4 Arpc5 Fbxw8 Gsdmd Fbxw7 Prcp Cyb5r3 Hras Nras Rhof Rhog Sos1 Ckap4 Tbc1d10c Shc1 Degs1 Tom1 Grb2 Rnf41 Vhl Socs5 Socs3 Nos3 RGD1308751 Dnm2 Itga4 Mavs Tnf Bpifa2 Atp6v1g1 Rnase6 Atp6v1g2 Atp6v0a4 Bpifa1 Rbck1 Atp6v1b2 Atp6v0a2 Fyn Atp6v1h Atp6v1f Stat6 LOC497963 Il1rl2 Il36rn Il1f10 Il1rap Il36b Il36a Bpifb4 Pglyrp3b Pglyrp3 Bpifb6 Pglyrp4 Pglyrp2 Itln1 Eppin Bpifa2f Chga Bpifa5 Rap1gap2 Reg3g Sipa1 Elane Adam8 Pik3ap1 Ube2d1 Il1rl1 Vcam1 LOC103690254 Try10 Atp6v0d1 LOC100365995 Herc2 Atp6v1c2 Atp6v0d2 Timp2 Ube2d3 Atp6v1a Atp6v0e2 Atp6v0e1 Atp6v1g3 Atp6v1e1 Atp6v1e2 Atp6v1c1 Stub1 Nos1 Calr MGC114246 Capn1 Testin Lyn Crkl Yes1 Hck Rapgef1 Ceacam10 Syk LOC100911248 Mmp8 Camk2g Itgam Mmp9 Try4 Camk2d Itgb7 Camk2a Madcam1 Wwp1 Itgb2 Canx Vtn Atp7a Ceacam1 Prkcq Siah1 Tlr4 Prss2 Ikbke Tank Traf3 Siah2 LOC100364523 Sar1b Apob Itgal Itgax Prss1 Icam4 Icam5 Il2rg Icam1 Rap1gap Ctsd Ctsb Ctsg Trem2 Ctsl Ctsm Ctsj RGD1564657 Vav2 Ctsk Ctsq Vav1 Ctsr LOC100909977 P4hb LOC102554637 Dnm1 Csk Dnm3 Vav3 Rasgrp1 Rasgrp3 Sos2 Il5 Cts8 Cts7 Il2 Il2ra Csf2 RGD1564827 Il3ra Icam2 Il2rb Pten Csf2ra Csf2rb Pla2g6 Raf1 Il5ra Psen1 Ncstn LOC364561 Pin1 LOC683849 Cd47 Cts8l1 Rasgrp2 Ttr Kif3a Il1b F2 Mre11a Pik3r3 Inpp5d Mtor Cpb2 Txn1 Mlst8 Akt3 Cd80 Cd86 Lgmn Lat2 Trem1 Ifitm3 Cd40lg Cd226 Smurf1 LOC100911324 Pvrl2 Ifitm2 Ifitm1 Sh2d1a Sh2d1b Ube2m Cd8b Cbl Cd8a RGD1561143 Slamf7 Siglec10 Slamf6 Npdc1 Treml2 Cd200r1 Cd200r1l LOC681182 Cd96 Dctn1 Dctn2 Il6st Dctn3 Myo9b Actr1a Il21r Klc1 Dync1li2 Il21 Abi1 Abi2 Potef Dync1i2 Panx1 Uba7 Myh9 Casp3 Nck1 Traf7 Glmn Uba5 Hecw2 Klc4 Mrc2 Sugt1 Ube2l6 Rbbp6 Cenpe Mrc1 Txnip Ube3d Klc2 Ube3b Mefv Pstpip1 Trim11 Klc3 P2rx7 Lrsam1 Ube3a Npepps Ube2o Arpc1b Ube2u Hectd3 LOC100909750 Hectd1 Rnf6 Erap1 Ncf1 Rnf4 Ncf4 Cd207 Tap1 Tap2 Traip Rnf25 Anapc13 Lnx1 Rnf19a Dynll2 Rnf19b Herc3 Sqstm1 Arih2 Herc6 Tapbp Dync1i1 Tpp2 Ubox5 Ube2j2 Arel1 Ube2j1 Ptk2 Rnf182 Actg1 Cyfip2 Rnf14 Ltn1 Nckap1 Cblb Sh3rf1 Pja1 Defb26 Pja2 Defb28 Ccr6 Hexb Dtx3l Defb30 Znrf2 Defb18 Znrf1 LOC100909609 Trim9 Defb36 Blmh Ptk2b Defb14 LOC100911400 Defb12 Pld2 Rnf115 Trim63 Dzip3 Trip12 Ubr2 Trim71 Defb29 Vprbp Defb49 Trim69 Defb25 Trim39 Defb43 Ube4a Defb44 LOC100910646 Ufl1 Trim50 Tax1bp1 Ubac1 Ube2q1 Thop1 Art1 Rlim Defb13 Mex3c Rchy1 Defb41 Defb1 Mgrn1 Pik3cd Trim41 Defb22 Hace1 Defb23 Trim36 Defb20 Trim37 Defb21 Fcgr1a Cd247 Pkm Nlrp3 Rnf144b Pgam1 Glb1 Dock1 Elmo2 Klrc2 Manba Fyb Aldoa Gyg1 Aldoc Cpn1 Cpn2 Cr2 Clu C5ar2 Cd46 Serping1 Brk1 Pfkl C6 Cfhr1 Pgm2 Cd19 C8g Pgm1 RGD1564614 Baiap2 Cd81 B4galt1 LOC100909468 C8a C8b Limk1 Sec13 Nf2 Pak2 Pak3 Pak1 Cfh Wasl Aldoart2 Abl1 Wasf1 Arpc4 Ppp2r5e G6pc Agl Arpc3 Cdc20 Kif2a Pla2g2a Kif2c Kif2b Kif18a Ppp2r5c Ppp2r5a Gpi Nckipsd LOC100361457 Ppp2r5b Xdh Cd209b Kif5b Cd209e Btn2a2 Kif5a Clec4m Cd79b Actr3 Cd79a Nfkbie Was Blnk Btn1a1 LOC684480 Mapk13 Cd209a Mapk12 Btnl2 Pik3c3 Dapp1 Cd79al Arsb Pik3r4 Pdpk1 Dhx36 Cdc42 Dera LOC100911597 Gusb Hpse Man2b1 Wipf1 Wipf2 Wipf3 Cd44 Psmc6 Psmb10 Psmb8 Gaa Psmb9 Psmb4 Psmb11 Psmb5 Pygl Psmf1 Psmb6 Psmd4 Psmb2 Psmd5 Psmd8 Psmd9 Psmb3 Psma8 Ppapdc1a Pld3 Ppapdc1b Prkaca Prkacb Itpr1 Rapgef4 Itpr3 Fbxl18 Fbxl7 Tlr9 Cd4 Irs2 Trib3 Il13ra1 Clcf1 Il13ra2 Il12b Il31ra Irak3 Il12a LOC100360218 Them4 Cntf Irs1 Csf3 Il23r Il1r1 Crlf2 Ebi3 Akt2 Il4r Il17c Il1rapl1 Map3k3 Il17a Il23a Birc3 Crlf1 Birc2 Aim2 Il4 Cyld Lif Stxbp2 Csf1r Ptprz1 Il13 Txlna Il11ra1 Tlr6 Lifr Il18r1 Tlr10 Il12rb1 Il12rb2 Csf3r Il17rc Il11 Stx3 Il18 Il16 Casp4 Ctf1 Casp1 Il1a Casp2 Il25 Osmr Nlrp1a Il17rb Il17ra Casp8 Il17re Il27ra Casp9 Socs1 Cntfr Osm Mylip Psmc5 Psma1 Cd3g Psma4 Psmc1 Psma3 Cd3d Psmc4 Psma6 Psme1 Psme2 Vamp3 LOC100909844 Vamp7 PORPHYRIN METABOLISM%REACTOME DATABASE ID RELEASE 66%10145085 Porphyrin metabolism Hmox1 Ugt1a8 Ugt1a9 Ugt1a6 Alad Blvrb Blvra Hmox2 Ugt1a1 Cpox Fech LOC687381 Ugt1a7c Ppox Ugt1a5 Hmbs Ugt1a3 Cox10 Ugt1a2 Alas2 LOC100911779 Cox15 Urod Uros RA BIOSYNTHESIS PATHWAY%REACTOME%R-RNO-5365859.1 RA biosynthesis pathway Dhrs3 Cyp26c1 Crabp1 Sdr16c5 Dhrs4 Rdh14 Rdh13 Aldh8a1 Dhrs9 Rdh10 Rdh16 Akr1c2 LOC100365958 Akr1c3 Akr1c12l1 Akr1c19 Rdh11 Cyp26a1 Adh6 Akr1c13 Akr1c14 RGD1564865 Akr1c12 Akr1c1 Cyp26b1 CLASSICAL KIR CHANNELS%REACTOME DATABASE ID RELEASE 66%10145835 Classical Kir channels Kcnj2 Kcnj4 Kcnj14 Kcnj12 REGULATION BY C-FLIP%REACTOME DATABASE ID RELEASE 66%10146009 Regulation by c-FLIP Faslg Traf2 Cflar Fadd Ripk1 Tradd Tnfsf10 Casp8 Fas PROTEIN UBIQUITINATION%REACTOME DATABASE ID RELEASE 66%10146215 Protein ubiquitination Usp7 Leo1 Cdc34 Ube2e3 Ctr9 Hist1h2bo Wdr61 Hist1h2bcl1 Pex2 Hist1h2bk Rad18 Pex5 Ube2z Pcna Ube2t Rnf152 Ube2s Uchl3 RGD1561252 Ube2v2 Ube2n Shprh Bcl10 Rnf20 Paf1 Rnf181 Cdc73 LOC100910200 Ube2g2 LOC100911393 Ube2g1 Hist1h2bh Usp9x Ube2d1 Rtf1 LOC100912338 Rnf40 Ube2d3 Otulin Hist1h2bq Uba1 LOC100364835 Pex14 Pex10 Pex13 Ube2q2 Pex12 Hltf Ube2r2 Ube2c Ube2k Ube2h Uba6 Rraga Ube2a Usp5 Hist1h2bg LOC103690024 LOC100911959 LOC684797 Hist1h2ba THROMBOXANE SIGNALLING THROUGH TP RECEPTOR%REACTOME%R-RNO-428930.1 Thromboxane signalling through TP receptor Gnb3 Gnb5 Tbxa2r Gnb2 Gnb1 Gnaq Gng13 Gna11 Gna14 Gng12 Gna15 Gng11 LOC100912034 Gnb4 Gng4 Gna13 Gngt2 Gng5 Gngt1 Gng10 Gng8 Gng3 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN%REACTOME%R-RNO-174154.1 APC C:Cdc20 mediated degradation of Securin Psmc6 Psmb10 Psmb8 Psmb9 Psmb4 Psmb11 Psmb5 Psmf1 Psmb6 Psmd4 Psmb2 Psmd5 Psmd8 Psmd9 Psmb3 Psma8 Psmd11 Psmd12 Anapc11 Anapc15 Psmd13 Anapc10 Psmd14 Psmc3 G6pc Ube2d1 Cdc20 Psmb7 Psmb1 Anapc7 Cdc26 Cdc27 Psma5 Cdc23 Pttg1 Ube2c Anapc16 Cdc16 Anapc4 Psma2 Anapc2 Anapc1 Psmc5 Psmd2 Psma1 Psma4 Psmc1 Psma3 Psmc4 Psmc2 Psma6 Psme1 Psmd1 Psme2 Psmd7 Psmd3 Psmd6 SHC1 EVENTS IN EGFR SIGNALING%REACTOME%R-RNO-180336.1 SHC1 events in EGFR signaling Kras Hras Nras Egfr Sos1 Shc1 Grb2 CHYLOMICRON REMODELING%REACTOME DATABASE ID RELEASE 66%10145241 Chylomicron remodeling Lpl Apob Apoa1 Gpihbp1 Apoc2 Apoe Apoa2 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA%REACTOME%R-RNO-72203.1 Processing of Capped Intron-Containing Pre-mRNA Thoc5 Thoc7 Thoc3 Thoc2 Thoc1 Ppie Thoc6 RGD1565904 Isy1 Polr2g Polr2h Polr2e Polr2f Polr2j Polr2k Polr2d Polr2i Polr2b Polr2c Ddx39a Polr2a Ddx39b Xab2 Chtop LOC100912534 Prpf19 Nup88 LOC100911822 Aqr Nup85 Fyttd1 Rae1 LOC361990 Nup93 Rnps1 Dhx16 Dhx15 Sugp1 Prpf40a Nup98 Sart1 Nup107 Snrpb2 Magohb Phf5a Rbm8a Ddx23 Pcf11 Fip1l1 Hnrnpa0 U2surp Nup210 Nudt21 Snrpd1 Eftud2 LOC100364748 Snrpd2 Snrpd3 Rbm5 Tra2b Sf3b2 Nupl2 Sf3b4 Sf3b3 Pqbp1 Nupl1 Sf3b5 Cstf2 Rbm22 Lsm8 Puf60 Wbp11 Lsm7 U2af1l4 Lsm6 Lsm4 Lsm3 Lsm5 Cpsf7 Cpsf2 Cpsf3 Cpsf4 Lsm2 Rbm17 Cstf1 Snrnp200 Cpsf1 Smptb Sarnp Gpkow Plrg1 LOC679753 Prpf6 Sf3a3 Sf3b1 Prpf8 Nup205 Prpf4 Ddx46 Sf3a1 Prpf31 Ddx42 Bcas2 Slu7 Prpf3 Sf3a2 Crnkl1 LOC100360750 Syf2 Fus Smndc1 Prcc Rbmx LOC100359916 Nup155 Snrpa1 Snrnp70 LOC679894 Nup153 Poldip3 Tpr Nup54 Pom121 Nup62 Cwc27 Cwc25 Cwc22 Nup43 Snrpf Nup133 Wdr33 Aaas Npap60 Nup35 Snrnp25 Zrsr1 Zcrb1 Nup37 Zmat5 Snrnp48 Rnpc3 Zrsr2 Snrnp35 Pdcd7 Ranbp2 Srsf3 Ccar1 Cdc5l Upf3b U2af2 LOC102548514 Cd2bp2 Papola Srsf6 Elavl1 Srsf7 Ppil6 Prpf38a Srsf4 Srsf5 Srsf2 Hnrnph1 Ppih LOC100359574 Ppil1 Ppil3 Elavl2 Srsf9 Ppil4 Dhx38 Fblim1 Clp1 Hnrnph2 Cwc15 Cherp Magoh Hnrpd Ncbp2 Srsf1 LOC100363335 Ctnnbl1 Ppwd1 LOC500684 Wtap Ncbp1 Dhx9 LOC680519 Ybx1 LOC100910750 Nhp2l1 Cstf2t Eif4a3 Sympk Bud31 Hnrnpul1 Txnl4a LOC100910660 Hnrnpk Srrm1 Hnrnpu Hnrnpr Wbp4 Usp39 Hnrnpl Snrpa Hnrnpm Hnrnpf Cdc40 Snrpc Hnrnpa2b1 Snrpb RGD1565693 Nxf7 Gle1 Mettl14 Nxf2 Nxf1 Gtf2f1 Gtf2f2 Snw1 Mettl3 Tcp11x2 Ddx5 Nxt1 INSULIN RECEPTOR RECYCLING%REACTOME%R-RNO-77387.1 Insulin receptor recycling Atp6v1d Tcirg1 Atp6v0d1 Atp6v1c2 Atp6v0d2 Atp6v1a Atp6v0e2 Atp6v0e1 Atp6ap1 Atp6v1g3 Atp6v1e1 Atp6v1e2 Atp6v1c1 Atp6v1g1 Atp6v1g2 Atp6v0a4 Atp6v0a1 Atp6v1b2 Atp6v0a2 Atp6v1h Atp6v1f Insr Ins1 Ins2 Atp6v0c INTERLEUKIN-6 SIGNALING%REACTOME DATABASE ID RELEASE 66%10145796 Interleukin-6 signaling Socs3 Ptpn11 Stat1 Il6st Jak1 Il6 Stat3 Cbl Tyk2 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%R-RNO-111447.1 Activation of BAD and translocation to mitochondria Ywhah Ywhag Sfn Ywhaz Ppp3r1 Bcl2 Bid Ywhab Ywhaq Ywhae Bad C-SRC MEDIATED REGULATION OF CX43 FUNCTION AND CLOSURE OF GAP JUNCTIONS%REACTOME%R-RNO-191647.1 c-src mediated regulation of Cx43 function and closure of gap junctions Gja1 Src EUKARYOTIC TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 66%10144835 Eukaryotic Translation Initiation LOC100912571 Eif3l Eif2s3 Eif3m Eif3j Eif4ebp1 Eif3k Rps20 Rps27l Eif3e Eif3f Eif2b1 Eif3b Eif3a Eif3d Eif3c LOC100360573 Eif2s1 Eif2s2 Eif4g1 Rps4x LOC100359951 LOC100359593 Eif5 LOC100359503 LOC100362640 Rpl13a Rps3 Rps15a Rps2 Rps13 Rps12 Pabpc2 Pabpc6 LOC100911372 LOC100361854 LOC684988 LOC103689992 Rps5 Rps7 Eif2b5 Rps6 Eif2b3 Eif2b4 Eif3g Eif3h Eif4a2 LOC100362830 Eif1ax Eif4a1 LOC100363012 LOC680559 LOC100911110 LOC100362149 Rps16 LOC100911431 Pabpc1 Rps18 LOC100360679 Rps15 Eif4h Eif4b Rps3a TIE2 SIGNALING%REACTOME%R-RNO-210993.1 Tie2 Signaling Kras Grb7 Dok2 Pik3r1 Pik3r2 Pik3cb Tek Ptpn11 Angpt1 Hras Nras Sos1 Angpt2 Angpt4 Shc1 Grb2 SMALL INTERFERING RNA (SIRNA) BIOGENESIS%REACTOME%R-RNO-426486.1 Small interfering RNA (siRNA) biogenesis Prkra Ago3 Dicer1 Tsnax Ago4 Ago2 Tsn Tarbp2 ARACHIDONATE PRODUCTION FROM DAG%REACTOME%R-RNO-426048.1 Arachidonate production from DAG Mgll Abhd12 Daglb Abhd6 Dagla NUCLEOTIDE EXCISION REPAIR%REACTOME%R-RNO-5696398.1 Nucleotide Excision Repair Rfc1 Rfc2 Gtf2h1 Gtf2h2 Usp7 Ddb2 Pole2 Pole4 Pias3 Pias1 Ppie Yy1 Ddb1 Mnat1 Rbx1 RGD1565904 Actr8 Isy1 Polr2g Polr2h Polr2e Polr2f Polr2j Polr2k Polr2d Polr2i Polr2b Polr2c Chd1l Polr2a Actl6a Mcrs1 Xab2 Cops8 LOC100912534 Cops2 Actb Sumo1 Rpa3 Lig3 Zfp830 Pole Prpf19 Sumo3 Ino80 Tcea1 Pcna Cul4b Uvssa Ccnh Cul4a Ube2v2 Hmgn1 Xpc Ube2n Xpa Ube2i Ruvbl1 Gtf2h3 Rfc5 Rfc4 Rfc3 Gtf2h5 Gtf2h4 Ercc5 Ercc8 Ercc3 Ercc6 Rpa1 Rpa2 LOC100911295 LOC100911822 Cops4 Aqr Cops6 Ercc2 Ercc1 Lig1 Cops3 Ino80e Ino80d Nfrkb Usp45 Xrcc1 Parp2 Parp1 Rad23a LOC100911727 Cdk7 Rad23b Cops7b Cops7a Pold2 Pold1 Pold4 Ino80b Ino80c CAP-DEPENDENT TRANSLATION INITIATION%REACTOME%R-RNO-72737.1 Cap-dependent Translation Initiation LOC100912571 Eif3l Eif2s3 Eif3m Eif3j Eif4ebp1 Eif3k Rps20 Rps27l Eif3e Eif3f Eif2b1 Eif3b Eif3a Eif3d Eif3c LOC100360573 Eif2s1 Eif2s2 Eif4g1 Rps4x LOC100359951 LOC100359593 Eif5 LOC100359503 LOC100362640 Rps3 Rps15a Rps2 Rps13 Rps12 Pabpc2 Pabpc6 LOC100911372 LOC100361854 LOC684988 LOC103689992 Rps5 Rps7 Eif2b5 Rps6 Eif2b3 Eif2b4 Eif3g Eif3h Eif4a2 LOC100362830 Eif1ax Eif4a1 LOC100363012 LOC680559 LOC100911110 LOC100362149 Rps16 LOC100911431 Pabpc1 Rps18 LOC100360679 Rps15 Eif4h Eif4b Rps3a TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE%REACTOME%R-RNO-168188.1 Toll Like Receptor TLR6:TLR2 Cascade Map2k7 Ripk2 Map2k6 Ager Dusp3 Map2k4 Map3k8 Dusp4 Peli3 Nfkbib LOC100912399 Peli2 Map3k1 Traf6 Cul1 Vrk3 Rps6ka2 Rps6ka1 App Rps6ka3 Rps6ka5 Tirap LOC100912585 Tab1 Dusp7 Dusp6 Rela Atf1 Atf2 Map3k7 Peli1 Irak2 Nfkbia LOC100910771 Ube2n Jun Ppp2cb Ppp2ca Skp1 Ppp2r1a Nfkb2 Nfkb1 Mapk9 Mapk8 Fos S100b Mapk7 Dhx9 Fbxw11 Chuk Ppp2r1b Ecsit Mapkapk3 Btrc Mapkapk2 Mapk1 Nkiras1 LOC100362142 Nod1 Nod2 Nkiras2 Creb1 Tab2 Tab3 LOC100912618 Ube2v1 Ikbkb Mapk14 Myd88 Tnip2 Mapk11 Mapk10 CARBOHYDRATE METABOLISM%REACTOME DATABASE ID RELEASE 66%10144766 Carbohydrate metabolism Xylb Ncan Hexb Hexa Chst7 Chst9 Ugp2 Slc9a1 Chst5 LOC102550316 Chst3 Nup88 Chst2 Chst1 B3gnt4 B3gnt7 B3gnt1 B3gnt2 B3gnt3 Nup85 Pgk2 G6pc3 Pgk1 Gpc6 Rbks Slc37a2 Pkm Taldo1 Chpf2 Gpc4 Gpc2 Ndst1 Pgam1 Pgam2 Ndst2 Rae1 Cryl1 Ndst3 Ndst4 Adpgk Ogn Glb1 Pck1 St3gal2 St3gal3 Slc26a2 Slc26a1 St3gal1 Bpgm Gpc1 Nhlrc1 Slc37a1 St3gal4 St3gal6 B3galt6 Nup93 Slc35b2 Epm2a Kera Nup98 LOC100911625 Nup107 Slc35b3 Eno3 Glyctk Gapdhs Manba Eno1 Tkfc Eno2 Nup210 Aldoa Prelp LOC100911750 Gyg1 Aldob Aldoc Cspg5 Cspg4 Nupl2 Pgls Gckr Nupl1 Pklr Acan Pc Dsel Tkt Bcan Pfkfb3 Pfkfb4 Pfkfb1 Pfkfb2 Chsy1 Khk Pfkl Pgm2 Prps2 Pgm1 LOC100910284 Pfkp B4galt1 Ext1 Ext2 B4galt3 B4galt2 B4galt6 B4galt7 B4galt4 B4galt5 Hs3st3b1 Nup205 Aldoart2 Naglu Slc25a11 Lalba Slc25a10 Phka1 Cemip Shpk Agrn Stab2 Hk2 Xylt2 Pgm2l1 G6pc Agl Chst12 Nup155 Chst11 Lum Dcn Tpi1 Csgalnact1 Csgalnact2 Hs6st2 Chst13 Prps1l1 Gys1 Gpi Gys2 Slc25a1 Rpia Papss2 Papss1 Hs6st1 Idua Ust Chst15 Chst14 Nup153 Rpe Vcan Phkg1 Gale Hs3st3a1 Omd Dse Tpr Glb1l Galk1 Akr1b1 Arsb LOC100910891 Phkg2 Man2c1 Gnpda2 Dera Akr1a1 Slc35d2 Nup54 Gusb Hpse Man2b1 Slc2a1 Pom121 Hs3st5 Chpf Nup62 Hs3st2 Hs3st1 Dcxr Hs3st6 Cd44 Phkb Lyve1 Nup43 Nup133 Mdh2 Gaa Mdh1 Has1 Aaas Pygl Has2 Pygm B3gat1 B3gat3 B3gat2 Npap60 Got1 Fbp1 Nup35 Fbp2 Hyal1 Nup37 Hyal2 Chp1 Sdc2 Sdc3 Sdc4 Sord Fmod Galt Got2 Hs2st1 Ranbp2 Ppp1r3c ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS%REACTOME%R-RNO-176187.1 Activation of ATR in response to replication stress Rfc2 Hus1 Rpa1 Rpa2 Mcm2 Atrip Mcm4 Mcm3 Cdk2 Mcm5 Clspn Rpa3 Mcm6 Mcm10 Rad1 Atr Mcm8 Mcm7 Rad17 Orc4 Orc5 Orc6 Orc1 Orc2 Orc3 Rfc5 Cdc7 Rfc4 Rad9a Rfc3 Cdc6 Rad9b Cdc45 EXTRACELLULAR MATRIX ORGANIZATION%REACTOME DATABASE ID RELEASE 66%10145031 Extracellular matrix organization Capn5 RGD1308751 Capn7 Itga4 Capn9 LOC102553715 Serpine1 Capn8 Itga6 Itga8 Itga7 Elane Col20a1 Ncan P4ha1 P4ha2 P4ha3 Adam8 Bsg LOC100910835 Col13a1 LOC100910384 Vcam1 F11r Sh3pxd2a LOC103690254 Serpinh1 Try10 LOC100365995 Ddr1 Col8a1 LOC102550316 Col8a2 Pdgfa Pdgfb Timp2 Timp1 Phykpl Col28a1 Col1a1 Cma1 Efemp1 Col1a2 Cdh1 Efemp2 Fbln2 Col18a1 MGC114246 A2m Fbln1 Kdr Fbln5 Dmp1 Capn15 Capn1 Itga3 Capn6 Scube3 Scube1 Capn3 Capn2 Capn10 Testin Lama4 Loxl4 Colgalt2 Plg Prkca Col14a1 Capn12 Loxl1 Capn11 Colgalt1 Lama1 Ceacam10 Col17a1 Capn13 Mmp8 Ibsp Itgam Mmp7 Col19a1 Itgae LOC100911730 Mmp9 Try4 Itgb6 Sparc Pcolce Mmp1 Mmp2 Itgb7 Itgb8 Madcam1 Itgb2 Cd151 Tnn Lamc1 Lamc2 Vtn Itgb4 Adam12 Adam19 Jam3 Col22a1 Fbn1 Acan Col16a1 Tnr Adam15 Ceacam1 Col5a2 Bcan Col5a1 Klk7 Col4a5 Col9a1 Col9a2 Col9a3 Mfap2 Col4a1 Fgb Prss2 Fgg LOC100910284 Mfap5 Mfap4 Col5a3 LOC100364523 Thbs1 Ctrb1 Optc Col4a2 Col4a3 Fga Mfap3 Lamb1 Itgal Dag1 Itgax Lamb2 Lamb3 Prss1 Spp1 Icam4 Agrn Mmp15 Mmp17 Icam5 Mmp11 Mmp12 Mmp14 Dst Icam1 Mmp13 Mmp19 Lum Adamts4 Adamts3 Dcn Adamts5 Klkb1 Comp Ctsd Ctsb Ctsg Ctsl Col3a1 Ctsm Itga10 Ctsj RGD1564657 Itga11 Ctsk Ctsq Ctsr Ppib Col6a1 Col6a2 Fn1 LOC100909977 Vcan P4hb LOC102554637 Adamts14 Tll2 Col11a2 Col11a1 Mmp20 Gdf5 Tmprss6 Tll1 Ltbp3 Ltbp2 Ltbp4 Ltbp1 Tpsab1 Mmp24 LOC100911572 P3h3 Cts8 Cts7 Col26a1 Itga2b Plod2 Plod1 RGD1564827 LOC102555086 Mmp16 Icam2 Plod3 Mmp10 Cd44 Sdc2 Sdc3 Sdc4 LOC683849 Furin LOC100911714 Tpsb2 Cd47 Cts8l1 Spock3 Col27a1 Htra1 Dspp Lox Plec Fgf2 Ttr Nid1 Nid2 Hapln1 Eln Bmp2 LOC100910122 Bmp1 Matn4 Bmp7 Bmp4 Crtap Matn1 Col7a1 Tgfb2 Tgfb1 Col23a1 Cast Tgfb3 Col6a5 Col6a6 LEADING STRAND SYNTHESIS%REACTOME%R-RNO-69109.1 Leading Strand Synthesis Rfc1 Rfc2 Prim2 Pola2 Prim1 Rfc5 Rfc4 Pold2 Rfc3 Pcna Pold1 Pold4 REGULATED PROTEOLYSIS OF P75NTR%REACTOME DATABASE ID RELEASE 66%10145335 Regulated proteolysis of p75NTR Nfkb1 Adam17 Aph1b Psenen Aph1a Ngfr Rela LOC100911293 Psen2 Psen1 Traf6 Ncstn MISMATCH REPAIR (MMR) DIRECTED BY MSH2:MSH3 (MUTSBETA)%REACTOME%R-RNO-5358606.1 Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Msh3 Msh2 Rpa1 Rpa3 Rpa2 LOC100911727 Pold2 Pold1 Lig1 Pold4 NEUTROPHIL DEGRANULATION%REACTOME%R-RNO-6798695.1 Neutrophil degranulation Ppie Elane Adam8 LOC103690254 Try10 LOC100365995 Timp2 Capn1 Ceacam10 Mmp8 Itgam Mmp9 Try4 Commd9 Pdxk Itgb2 Cd53 Atg7 Xrcc6 Bpi Hbb-b1 Xrcc5 Cd59 Ceacam1 Np4 Ctsa Ptprc Cyfip1 Serpinb3a Cd63 Pnp Sdcbp RGD1304587 Cct2 Apaf1 Prss2 LOC100909857 Ddost LOC498300 Vamp8 Defa7 Gdi2 Anpep Plaur Serpinb12 Cct8 Defa5 Cst3 Dnajc13 Nckap1l Itgal Serpinb10 LOC100909879 Itgax Ilf2 Qsox1 Mpo Prss1 Fcgr3a LOC685953 Slc2a5 Cd36 Ctsc Rock1 Rap2b Syngr1 Tmem179b Svip Serpinb1b Ctsz Mlec Arg1 Frk Serpinb1a Cstb Psmb7 Ctsd Psmb1 Ctsb Vapa Ctsg Lrrc7 Prdx4 Gmfg C5ar1 Nme2 LOC687609 Dsn1 Lrmp Rap2c Grn Stom Dsp Cab39 Cd14 LOC100909977 LOC100909700 Atp6v0a1 LOC102554637 Ltf Psma5 Slpi Padi2 Plekho2 Rap1a Fcer1g Tollip Gsn Pkp1 Chi3l1 Psma2 Pglyrp1 Snap29 Psmd2 Commd3 Idh1 Bst1 Ptpn6 Psmc2 Fgl2 Tnfaip6 Psmd1 Psmd7 Iqgap1 Prdx6 Tspan14 Psmd3 Psmd6 Psen1 Ncstn LOC683849 Cd47 Ttr Nfkb1 Mapk1 Mapk14 Ddx3x Plac8 RGD1563818 Cotl1 Cmtm6 RT1-A2 Lpcat1 RT1-A1 Ggh Clec5a B2m LOC100125364 Glipr1 Rnaset2 Gpr84 RGD1561778 Ist1 Cpped1 Cand1 A1bg Clec4d Hexb Pkm Pgam1 Glb1 Manba Aldoa Gyg1 Aldoc Pfkl Pgm2 Pgm1 B4galt1 Aldoart2 Agl Gpi Arsb Dera Gusb Hpse Man2b1 Cd44 Atp6v1d Cda Lamp1 Ftl1 Psap RatNP-3b Gaa Svs1 Fuca2 Serpinb6b Igf2r Pygl Lrg1 RGD1306474 Magt1 Rac1 Acly Cap1 Pdap1 Doxl2 Doxl1 Cpne3 Rnase17 Rab27a Psmd11 Psmd12 Fabp5 Dynlt1 Psmd13 Psmd14 Tmem30a Lamp2 Unc13d Mif Ap2a2 Crisp3 Cfp S100a11 Aga Cfd RT1-M3-1 Serpinb3 Atp8a1 Kcmf1 Aldh3b1 Ndufc2 Serpinb6 Aprt Faf2 Cpne1 Psmc3 Diaph1 Trpm2 LOC100364500 Defa11 Fcnb Defa10 RT1-S3 Cant1 Tmem173 Cxcr2 Atp6v0c RGD1564463 Anxa2 Mgst1 Retn RT1-CE2 Dpp7 Nit2 RT1-CE3 RT1-CE4 RT1-CE7 RT1-CE5 Slco4c1 Hsp90ab1 RGD1561661 Rab3a Copb1 Cat Cd177 RT1-CE10 Hebp2 Rab7a Ptges2 Ptafr Tubb5 Creg1 Pigr Mettl7a Alox5 Kcnab2 Pygb Rab4b Ticam2 Mme Neu1 Lta4h Ms4a3 Cxcl2 Cxcl1 Epx S100a8 Cd68 Rab5b Cxcl3 Rab5c Chit1 Ampd3 Slc27a2 Dgat1 Rab6a LOC683761 LOC100364956 Atp6ap2 Tmem63a Ptprn2 Nhlrc3 Naprt1 Ano6 Pa2g4 Gm2a Dbnl Fcgr2b LOC103693683 Atad3a Serpina3m Rab9b Fcgr2a Trappc1 Tlr2 Plau Slc11a1 Kpnb1 Chrnb4 Fpr1 Arl8a Pld1 Ostf1 Ear1 Vcl Prg3 Erp44 Stk10 Sptan1 Vcp Prg2 Rab18 Ghdc LOC100910990 Slpil3 Rab10 Rab14 Slpil2 Vnn1 Rab24 Actr10 Nbeal2 Lamtor3 RT1-A Arsa Tmbim1 Dok3 Dync1h1 P2rx1 Acaa1a Acaa1b Lamtor2 Lamtor1 Apeh Ypel5 Dync1li1 Slc44a2 LOC103692716 Qpct RGD1565355 Cybb Cyba LOC361635 Actr1b RT1-M2 Hmha1 Lgals3 RT1-M5 RT1-M4 Nfam1 Ubr4 Crispld2 Pycard Stk11ip Rab3d Rbm12 Galns Gca C3ar1 Prkcd Armc8 Olfm4 Fcar Gstp1 Asah1 Mnda Bri3 Ptx3 Srp14 Tcirg1 Hmox2 Ptprj Jup Mospd2 Impdh1 Impdh2 Ap1m1 Nfasc Rnase3 LOC100360575 Rnase2 Enpp4 Sirpa Tyrobp LOC100360087 Cdk13 LOC299277 Golga7 Hvcn1 Stbd1 Dsg1 Txndc5 Dnajc5 Csnk2b Actr2 Fgr Alad Gla Dnajc3 Tnfrsf1b Arhgap9 RGD1559482 C3 RT1-M6-1 Lair1 Ppbp Atp11a Vat1 Aoc1 RT1-M6-2 Agpat2 Rhoa Eef2 Arpc5 Gsdmd Prcp Cyb5r3 Nras Rhof Rhog Ckap4 Tbc1d10c Degs1 Tom1 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA%REACTOME DATABASE ID RELEASE 66%10145918 Regulation of innate immune responses to cytosolic DNA Nlrp4 Dtx4 Tbk1 Ddx41 Nlrp4a Irf3 Trim21 Trim32 Tmem173 RHO GTPASES ACTIVATE CIT%REACTOME DATABASE ID RELEASE 66%10146123 RHO GTPases activate CIT Rhoa Rhob Rac1 Dlg4 Prc1 Rhoc Cit FORMATION OF INCISION COMPLEX IN GG-NER%REACTOME%R-RNO-5696395.1 Formation of Incision Complex in GG-NER Gtf2h1 Gtf2h2 Ddb2 Pias3 Pias1 Ddb1 Mnat1 Rbx1 Ercc5 Ercc3 Rpa1 Rpa2 Chd1l Ercc2 Ercc1 Usp45 Parp2 Sumo1 Parp1 Rpa3 Rad23a Cdk7 Rad23b Sumo3 Cul4b Ccnh Cul4a Ube2v2 Xpc Ube2n Xpa Ube2i Gtf2h3 Gtf2h5 Gtf2h4 NTF3 ACTIVATES NTRK3 SIGNALING%REACTOME%R-RNO-9034013.1 NTF3 activates NTRK3 signaling Ntrk3 Ntf3 REMOVAL OF THE FLAP INTERMEDIATE%REACTOME DATABASE ID RELEASE 66%10144734 Removal of the Flap Intermediate Rpa1 Slc25a16 Rpa3 Fen1 Rpa2 Prim2 Pola2 Prim1 Pold2 Pcna Pold1 Pold4 THE PROTON BUFFERING MODEL%REACTOME%R-RNO-167827.1 The proton buffering model Ucp2 Ucp3 LOC100909612 Slc25a14 Ucp1 POTASSIUM TRANSPORT CHANNELS%REACTOME%R-RNO-1296067.1 Potassium transport channels Kcnj16 RUNX2 REGULATES OSTEOBLAST DIFFERENTIATION%REACTOME%R-RNO-8940973.1 RUNX2 regulates osteoblast differentiation Runx2 BUTYRATE RESPONSE FACTOR 1 (BRF1) BINDS AND DESTABILIZES MRNA%REACTOME%R-RNO-450385.1 Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Dcp2 Exosc3 Akt1 Mapkapk2 LOC100911537 Xrn1 Dcp1a Exosc9 Exosc2 Exosc1 Exosc4 Exosc7 Exosc5 Ywhab NEUROTRANSMITTER CLEARANCE%REACTOME%R-RNO-112311.1 Neurotransmitter clearance Maoa Ache Slc22a1 Slc22a2 Aldh2 Comt Slc6a4 Slc6a3 Bche Lrtomt RUNX3 REGULATES YAP1-MEDIATED TRANSCRIPTION%REACTOME DATABASE ID RELEASE 66%10146278 RUNX3 regulates YAP1-mediated transcription Yap1 Tead2 Tead1 ESTABLISHMENT OF SISTER CHROMATID COHESION%REACTOME DATABASE ID RELEASE 66%10145970 Establishment of Sister Chromatid Cohesion LOC100910252 Stag1 Esco1 Pds5b Pds5a Cdca5 Rad21 Smc1a Stag2 Smc3 Esco2 PRC2 METHYLATES HISTONES AND DNA%REACTOME%R-RNO-212300.1 PRC2 methylates histones and DNA Eed LOC100910200 H2afx Hist1h4b Phf19 LOC684841 Hist1h2bh Dnmt1 LOC100912290 Rbbp7 Hist1h2ail1 Hist1h4m LOC102549173 LOC103690002 LOC100910152 Dnmt3a LOC100912338 Hist1h3c H2afb3 Hist1h3f Dnmt3b Hist2h4 LOC684819 Hist1h3a H2afj Hist2h2aa3 Hist1h2bq Hist2h2aa2 Mtf2 Phf1 LOC100364835 LOC684762 Hist1h2bo Hist1h2bcl1 Hist2h3c2 Hist1h2bk H3f3b Jarid2 Hist1h2bg Ezh2 LOC680097 LOC684797 LOC100912418 Hist1h2ba Hist3h2bb Aebp2 FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION%REACTOME%R-RNO-434316.1 Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Plcb1 Plcb3 Ffar1 Gnaq Gna11 Gna14 Gna15 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION%REACTOME%R-RNO-381340.1 Transcriptional regulation of white adipocyte differentiation Rxra Pparg INTERLEUKIN-20 FAMILY SIGNALING%REACTOME%R-RNO-8854691.1 Interleukin-20 family signaling Stat5a Jak3 Il22 Il24 Il19 Stat1 Il22ra1 Jak1 Stat2 Stat3 Il10rb Ptpn11 Il22ra2 Il20ra Il20rb Tyk2 Ifnl3 Il20 Ifnlr1 RHO GTPASE EFFECTORS%REACTOME DATABASE ID RELEASE 66%10144888 RHO GTPase Effectors Cenpn Zwilch Cenpl Cenpo Klc1 Dync1li2 Cenpt Cenpu Abi1 Bub3 Bub1 Abi2 Potef Spdl1 Kntc1 Dync1i2 Mad1l1 Rtkn Myh9 Nck1 Cenpk Cenph Cenpi Rock2 Klc4 Cenpf Kdm1a Cenpe Cenpm Klc2 Ahctf1 Klc3 Ndel1 Rcc2 Noxo1 Arpc1b LOC100909750 Actb Pafah1b1 Rhpn1 Ncf1 Ncf4 Rhpn2 Ppp1r12a LOC100361515 Mis12 Dynll2 Ndc80 Cenpc Noxa1 Ppp1r14a Cenpa Dync1i1 Daam1 Srgap2 LOC100909840 Ptk2 Actg1 Cyfip2 Birc5 Nckap1 Taok1 Nup85 Cdh1 Rhob Dlg4 Rhoc Myh14 Nup98 Myh11 Nup107 Prc1 Cit Cdca8 Flna Pkn1 Evl Cyfip1 Tax1bp3 Pkn2 Pkn3 Brk1 Cdc25c Rangap1 Fmnl1 Ppp1cb Baiap2 Ppp1cc LOC100909468 Aurkb Limk1 Sec13 Nf2 Xpo1 Pak2 Pak3 Pak1 Rac2 Wasl LOC100911204 Nckap1l Spc24 Spc25 Nox3 Nox1 Abl1 Itgb3bp Sgol2 Rhod Wasf1 Arpc4 Ppp2r5e Rock1 Incenp Rhoq Ktn1 Arpc3 Nsl1 LOC102551071 B9d2 Cdc20 Kif2a Kif2c Kif2b Men1 Bub1b Kif18a Ppp2r5c Ppp2r5a Nckipsd LOC100361457 Ppp2r5b Zwint Mylk Dsn1 Kif5b Mad2l1 Kif5a Casc5 Actr3 Lin7b Was Clasp2 Ercc6l Ctnna1 Nuf2 Pik3c3 Ncoa2 Clasp1 LOC679582 Iqgap3 Dvl1 Mkl1 Pik3r4 Pdpk1 Mapre1 Cdc42 LOC100911597 Pmf1 Dvl2 Dvl3 Pfn1 Pfn2 Ckap5 Scai Ska2 Wipf1 Wipf2 Wipf3 Iqgap1 Sgol1 Zw10 Srf Ska1 Nup43 Nup133 Rac1 Nup37 Diaph1 Ranbp2 Src Ppp2cb Ywhah Ppp2ca Ywhag Ppp2r1a Sfn Ywhaz Ywhab Ywhaq Ywhae Ppp2r1b Mapk1 Hist1h2bo Dync1h1 Hist1h2bcl1 Hist2h3c2 Hist1h2bk H3f3b Dync1li1 Cybb Cyba LOC100910200 H2afx Hist1h4b LOC684841 Hist1h2bh LOC100912290 Hist1h2ail1 Hist1h4m LOC102549173 LOC103690002 LOC100910152 LOC100912338 Hist1h3c H2afb3 Hist1h3f Hist2h4 LOC684819 Hist1h3a H2afj Hist2h2aa3 Hist1h2bq Hist2h2aa2 LOC100364835 LOC684762 Actr2 Rhoa Arpc5 Hist1h2bg LOC680097 LOC684797 Rhog LOC100912418 Hist1h2ba Hist3h2bb Grb2 HDL CLEARANCE%REACTOME%R-RNO-8964011.1 HDL clearance Scarb1 Cubn Amn Hdlbp Apoa1 BIOSYNTHESIS OF DHA-DERIVED SPMS%REACTOME DATABASE ID RELEASE 66%10146302 Biosynthesis of DHA-derived SPMs Hpgd LOC100361547 Gpx4 Cyp3a23/3a1 Cyp3a73 Cyp2d5 Cyp2c7 Alox12 Cyp2e1 Ltc4s Gstm4 Cyp2d4 Cyp3a18 Alox5 Cyp1a1 LOC100910877 Cyp2d2 Ptgs2 Ephx2 Cyp1a2 Alox15 Cyp2d3 Lta4h Cyp2c6v1 IRS-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%R-RNO-2428928.1 IRS-related events triggered by IGF1R Pik3r1 Pik3r2 Fgf23 Fgf22 Fgf4 Fgf1 Fgf3 Tlr9 Fgf6 Fgf5 Fgf20 Gab1 Pde3b Igf2 Igf1 Fgf16 Pik3c3 Fgf17 Irs2 Fgf10 Fgf9 Fgfr2 Fgf7 Fgf2 Fgf8 Pik3r4 Fgfr3 Trib3 Pdpk1 Fgfr1 Fgfr4 Pik3cb Ptpn11 Fgf19 Them4 Irs1 Frs2 Sos1 Akt2 Grb2 INSULIN RECEPTOR SIGNALLING CASCADE%REACTOME DATABASE ID RELEASE 66%10144875 Insulin receptor signalling cascade Pik3r1 Pik3r2 Fgf23 Fgf22 Fgf4 Fgf1 Fgf3 Tlr9 Fgf6 Fgf5 Fgf20 Gab1 Pde3b Fgf16 Pik3c3 Fgf17 Irs2 Fgf10 Fgf9 Fgfr2 Fgf7 Fgf2 Fgf8 Fgfr3 Pik3r4 Trib3 Pdpk1 Fgfr1 Mapk1 Fgfr4 Grb10 Pik3cb Ptpn11 Insr Ins1 Ins2 Fgf19 Them4 Irs1 Frs2 Sos1 Shc1 Akt2 Grb2 P2Y RECEPTORS%REACTOME%R-RNO-417957.1 P2Y receptors P2ry6 Lpar6 P2ry4 P2ry1 Gpr17 Lpar4 P2ry12 P2ry2 P2ry10 P2ry13 REGULATION OF ORNITHINE DECARBOXYLASE (ODC)%REACTOME DATABASE ID RELEASE 66%10145465 Regulation of ornithine decarboxylase (ODC) Nqo1 Psmc6 Oaz3 Psmb10 Oaz1 Oaz2 G6pc Psmb8 Psmb9 Psmb4 Psmb11 Psmb5 Psmf1 Psmb6 Psmd4 Psmb2 Psmd5 Psmd8 Psmb7 Psmd9 Psmb1 Psmb3 Azin1 Psma8 Psmd11 Psmd12 Psmd13 Psmd14 Psma5 Psma2 Psmc3 Psmc5 Psmd2 Psma1 Psma4 Psmc1 Psma3 Psmc4 Psmc2 Psma6 Psme1 Odc1 Psmd1 Psme2 Psmd7 Psmd3 Psmd6 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS%REACTOME%R-RNO-174417.1 Telomere C-strand (Lagging Strand) Synthesis Rfc1 Rfc2 Rpa3 Pole2 Pole4 LOC100911727 Pole Pold2 Pcna Pold1 Pold4 Rpa1 Slc25a16 Rpa2 Fen1 Prim2 Pola2 Prim1 Rfc5 Rfc4 Rfc3 Lig1 PROTON-COUPLED MONOCARBOXYLATE TRANSPORT%REACTOME DATABASE ID RELEASE 66%10145649 Proton-coupled monocarboxylate transport Bsg Slc16a3 Slc16a7 Slc16a8 Slc16a1 INSULIN EFFECTS INCREASED SYNTHESIS OF XYLULOSE-5-PHOSPHATE%REACTOME%R-RNO-163754.1 Insulin effects increased synthesis of Xylulose-5-Phosphate Tkt Taldo1 TRANSPORT OF NUCLEOSIDES AND FREE PURINE AND PYRIMIDINE BASES ACROSS THE PLASMA MEMBRANE%REACTOME%R-RNO-83936.1 Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane Slc28a2 Slc28a1 Slc28a3 Slc29a3 Slc29a2 Slc29a4 LOC100911721 Slc29a1 LOC691960 METHYLATION%REACTOME DATABASE ID RELEASE 66%10144922 Methylation N6amt1 Nnmt Mat2a As3mt Tpmt Mtrr Trmt112 Gsto1 Mtr Comt Mat1a Cyp1a2 Mat2b LOC100363915 Ahcy GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION%REACTOME%R-RNO-381676.1 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Rap1a Gnb3 Gnb5 Kcnc2 Gnb2 Gnb1 Gng13 Gng12 Gng11 Prkaca Prkacb Itpr1 Kcns3 Rapgef4 Itpr3 LOC100912034 Gnb4 Glp1r Gcg Gng4 Gngt2 Gng5 Gngt1 Gng10 Gng8 Gng3 CHYLOMICRON ASSEMBLY%REACTOME DATABASE ID RELEASE 66%10145238 Chylomicron assembly P4hb Sar1b Apob Apoa1 Apoc2 Apoe Apoa2 Mttp MYD88-INDEPENDENT TLR4 CASCADE%REACTOME%R-RNO-166166.1 MyD88-independent TLR4 cascade Map2k7 Ripk2 Tbk1 Map2k6 Ager Dusp3 Irf3 Map2k4 Map3k8 Dusp4 Nfkbib Traf6 Cul1 Vrk3 Rps6ka2 Rps6ka1 App Rps6ka3 Rps6ka5 LOC100912585 Tab1 Dusp7 Dusp6 Rela Atf1 Atf2 Map3k7 Irak2 Tlr4 Ikbke Tank Traf3 Nfkbia LOC100910771 Ube2n Jun Ppp2cb Ppp2ca Skp1 Ppp2r1a Ticam2 Nfkb2 Cd14 Nfkb1 Mapk9 Mapk8 Fos S100b Mapk7 Dhx9 Fbxw11 Chuk Ppp2r1b Mapkapk3 Btrc Mapkapk2 Mapk1 Nkiras1 LOC100362142 Nod1 Ptpn11 Nod2 Nkiras2 Creb1 Tab2 Tab3 LOC100912618 Ube2v1 Ikbkb Mapk14 Myd88 Tnip2 Mapk11 Mapk10 HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145724 Highly calcium permeable postsynaptic nicotinic acetylcholine receptors Chrnb4 Chrna4 Chrna5 Chrna9 Chrna6 Chrnb2 Chrna7 Chrnb3 Chrna2 Chrna3 Chrna1 G ALPHA (12 13) SIGNALLING EVENTS%REACTOME%R-RNO-416482.1 G alpha (12 13) signalling events Rock2 Gng10 Arhgef6 Arhgef5 Arhgef39 Arhgef7 Rock1 Arhgef37 Arhgef38 Arhgef33 Prex1 Adra1a Tbxa2r Itsn1 Arhgef2 LOC102556447 Arhgef4 Arhgef3 Plekhg5 Arhgef19 Arhgef18 Plekhg2 Kalrn Adra1d Plxnb1 LOC100912512 Gna12 Vav2 Gna13 Vav1 Arhgef11 Akap13 Arhgef16 Arhgef15 Net1 Ect2 Arhgef26 Fgd2 Mcf2l Tiam1 Tiam2 Vav3 Gnb3 Gnb5 Gnb2 Fgd3 Gnb1 Gng13 Sos2 Gng12 Ngef Gng11 Rhoa LOC100912034 Gnb4 Gng4 Gngt2 Sos1 Gng5 Rhob Gngt1 Gng8 Rhoc Gng3 EPHRIN SIGNALING%REACTOME%R-RNO-3928664.1 Ephrin signaling Src Arhgef7 Fyn Ephb1 Ephb2 Sdcbp Rac1 Pak2 Pak3 Pak1 Ephb4 Ephb3 Efnb2 Efnb1 Efnb3 Myl12a Nck2 METABOLISM OF NITRIC OXIDE%REACTOME DATABASE ID RELEASE 66%10145396 Metabolism of nitric oxide Nosip Nos3 Dnm2 Ddah2 Zdhhc21 Nostrin Ddah1 Wasl Spr Cygb LOC103692716 Akt1 SUMOYLATION OF UBIQUITINYLATION PROTEINS%REACTOME%R-RNO-3232142.1 SUMOylation of ubiquitinylation proteins Nup93 Nup43 Nup98 Nup133 Trim27 Mdm2 Nup107 Vhl Aaas Pias1 Nup155 Nup210 Npap60 Nup35 Nup88 Nup37 Pias4 Nupl2 Pml Pias2 Nupl1 Nup85 Nup153 Sumo1 Tpr Rae1 Nup54 Ube2i Pom121 Nup205 Ranbp2 Nup62 SIGNALING BY TGF-BETA RECEPTOR COMPLEX%REACTOME%R-RNO-170834.1 Signaling by TGF-beta Receptor Complex Smad3 Ccnt2 Smad2 Pard6a Nedd8 Fkbp1a Strap Usp9x Sp1 Ube2d1 Skil Rbl1 F11r Ncor2 Cdk9 Mtmr4 E2f4 Men1 Zfyve9 Hdac1 Arhgef18 Tgif2 Tgif1 Atp1b4 Trim33 Pmepa1 Ccnk Ube2d3 Pard3 Bambi Wwtr1 Tfdp1 Prkcz Tfdp2 Furin Stub1 Smurf1 Parp1 Tgfbr1 Ube2m E2f5 Cbl Hdac1l Snw1 Tgfbr2 Cgn Rhoa Tgfb1 SIGNALING BY HEDGEHOG%REACTOME%R-RNO-5358351.1 Signaling by Hedgehog Psmc6 Psmb10 Psmb8 Psmb9 Psmb4 Psmb11 Psmb5 Psmf1 Psmb6 Psmd4 Psmb2 Rbx1 Psmd5 Psmd8 Psmd9 Psmb3 Psma8 Psmd11 Psmd12 Psmd13 Psmd14 Disp2 Adcy8 Rpgrip1l Adcy9 Adcy5 Adcy4 Adcy7 Adcy6 Prkar1b Prkar1a Smo Wdr35 Evc2 Kif3a Ift88 Psmc3 Skp1 Btrc Prkaca Prkacb Vcp Cul1 Smurf1 Mks1 Cdc73 Csnk1a1 RGD1564313 Dzip1 Sufu G6pc Dhh Cdon Shh Ptch1 Efcab7 Spop Iqce Spopl Ofd1 Ulk3 Psmb7 Boc Psmb1 Gli1 Gli3 Gli2 Adcy3 Prkar2b Prkar2a Ihh Ift122 Os9 Evc RGD1559714 Wdr19 Ttc21b RGD1563667 Erlec1 P4hb Psma5 Psma2 Psmc5 Arrb1 Psma1 Psmd2 Ift52 Psma4 Kif7 Psmc1 Arrb2 Psma3 Ift57 Gas1 Psmc4 Psma6 Hhip Psmc2 Gas8 Psme1 LOC689173 Psmd1 Psme2 Psmd7 Adrbk1 Gpr161 Scube2 Ift140 Sel1l Psmd3 Tulp3 Psmd6 GABA A (RHO) RECEPTOR ACTIVATION%REACTOME DATABASE ID RELEASE 66%10145776 GABA A (rho) receptor activation Gabrr1 Gabrr3 Gabrr2 SYNTHESIS OF PIPS IN THE NUCLEUS%REACTOME%R-RNO-8847453.1 Synthesis of PIPs in the nucleus Tmem55b Pip4k2b Pip4k2c TP53 REGULATES METABOLIC GENES%REACTOME DATABASE ID RELEASE 66%10144779 TP53 Regulates Metabolic Genes Akt1 Gpi Ywhah Ywhag Sfn Ywhaz Sesn2 Txnrd1 Sesn1 RragB Lamtor3 Ywhab Prkab1 Sesn3 Ywhaq Ywhae Prkab2 Gsr Mtor Prdx1 Ddit4 Rheb Lamtor2 Prkag3 Lamtor1 Rptor Lamtor4 LOC502894 Tsc1 Lamtor5 Txn1 Mlst8 Prkaa1 Tsc2 Rraga Prkaa2 Rragc Akt3 Rragd Slc38a9 Akt2 VLDL ASSEMBLY%REACTOME%R-RNO-8866423.1 VLDL assembly P4hb Apob Apoc1 LOC100910181 Apoc4 Mttp GLYCOSPHINGOLIPID METABOLISM%REACTOME%R-RNO-1660662.1 Glycosphingolipid metabolism Hexb Hexa Psap Asah1 Neu4 Neu2 Gltp B4galnt1 Neu3 Cerk Enpp7 Neu1 Gba Arsa Galc Asah2 Arsi Smpd1 Ctsa Arse Cptp Arsg Smpd2 Gla Esyt3 Smpd3 Arsk Glb1l Sts Esyt2 Smpd4 Arsb Gba2 Sumf2 Sumf1 B3galnt1 Ugt8 Glb1 Ugcg Gm2a PCP CE PATHWAY%REACTOME%R-RNO-4086400.1 PCP CE pathway Psmc6 Psmb10 Psmb8 Psmb9 Psmb4 Psmb11 Psmb5 Psmf1 Psmb6 Rac1 Psmd4 Psmb2 Psmd5 Psmd8 Psmd9 Psmb3 Psma8 Psmd11 Psmd12 Psmd13 Psmd14 Ap2a2 Smurf1 LOC100361515 Psmc3 Rac2 Daam1 Pard6a G6pc Wnt5b Wnt5a Prickle1 Fzd1 Cltc Psmb7 Cltb Psmb1 Fzd3 Clta Fzd2 Fzd4 Fzd7 Fzd6 Prkcb Ap2s1 Wnt1 Wnt11 Wnt4 Ap2a1 Ror1 Ror2 Ap2m1 Psma5 Dvl1 Psma2 Psmc5 Psma1 Psmd2 Psma4 Dvl2 Arrb2 Dvl3 Psmc1 Rhoa Psma3 Pfn1 Psmc4 Psmc2 Prkca Psma6 Psme1 Psmd1 Psme2 Psmd7 Psmd3 Psmd6 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA%REACTOME%R-RNO-1234176.1 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Psmc6 Psmb10 Psmb8 Vhl Psmb9 Psmb4 Psmb11 Psmb5 Psmf1 Psmb6 Psmd4 Psmb2 Rbx1 Psmd5 Psmd8 Psmd9 Psmb3 Psma8 Psmd11 Psmd12 Psmd13 Psmd14 Egln2 Tceb2 Tceb1 Cul2 Hif1a Limd1 Psmc3 Epas1 Hif3a Egln3 Ajuba G6pc Ube2d1 Psmb7 Psmb1 Ube2d3 Psma5 Psma2 Psmc5 Psmd2 Psma1 Psma4 Psmc1 Psma3 Psmc4 Psmc2 Psma6 Psme1 Psmd1 Psme2 Psmd7 Psmd3 Psmd6 OREXIN AND NEUROPEPTIDES FF AND QRFP BIND TO THEIR RESPECTIVE RECEPTORS%REACTOME%R-RNO-389397.1 Orexin and neuropeptides FF and QRFP bind to their respective receptors Npff Npffr2 RGD1560028 Hcrt Npffr1 Qrfp LOC100909783 Hcrtr1 Qrfpr Hcrtr2 REGULATION OF TP53 EXPRESSION AND DEGRADATION%REACTOME%R-RNO-6806003.1 Regulation of TP53 Expression and Degradation Usp7 Mdm2 Akt1 Ppp2r5c Ppp2cb Ppp2ca Ppp2r1a Ccna2 Ccna1 Rffl Ccng1 Phf20 Atm Rictor Mtor Usp2 Cdk2 Daxx LOC100910954 Cdk1 Ppp2r1b Mdm4 Mlst8 Chek2 Pdpk1 Rnf34 Mapkap1 Sgk1 Akt3 Akt2 METABOLISM OF SEROTONIN%REACTOME%R-RNO-380612.1 Metabolism of serotonin Maoa Aldh2 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION%REACTOME DATABASE ID RELEASE 66%10145589 Adrenaline,noradrenaline inhibits insulin secretion Adcy5 Adra2a Gnai2 Adcy6 Adra2c Gnb3 Gnb5 Gnb2 Gnb1 Gng13 Gng12 Gng11 LOC100912034 Gnb4 Gng4 Gnai1 Gngt2 Gng5 Gngt1 Gng10 Gng8 Gng3 DECTIN-1 MEDIATED NONCANONICAL NF-KB SIGNALING%REACTOME%R-RNO-5607761.1 Dectin-1 mediated noncanonical NF-kB signaling Psmc6 Psmb10 Psmb8 Psmb9 Psmb4 Psmb11 Psmb5 Psmf1 Psmb6 Psmd4 Cul1 Psmb2 Psmd5 Psmd8 Psmd9 Psmb3 Psma8 Psmd11 Psmd12 Psmd13 Psmd14 Ube2m Psmc3 G6pc Psmb7 Psmb1 Skp1 Nfkb2 Psma5 Fbxw11 Chuk Btrc Psma2 Psmc5 Psmd2 Uba3 Psma1 Map3k14 Psma4 Relb Psmc1 Psma3 Psmc4 Psmc2 Psma6 Psme1 Psmd1 Psme2 Psmd7 Psmd3 Psmd6 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME DATABASE ID RELEASE 66%10145920 NOTCH2 Activation and Transmission of Signal to the Nucleus Notch2 Mdk Dll4 ESTROGEN-DEPENDENT GENE EXPRESSION%REACTOME%R-RNO-9018519.1 Estrogen-dependent gene expression Yy1 Med1 RGD1565904 Polr2g Polr2h Polr2e Polr2f Polr2j Polr2k Polr2d Polr2i Polr2b Kdm1a Polr2c Atf2 Polr2a Cited1 Hist1h2bo Hist1h2bcl1 Nr5a2 Hist2h3c2 LOC100912534 Gtf2f1 Gtf2f2 Hist1h2bk Kdm4b H3f3b Carm1 Greb1 Usf1 Gtf2a1 Foxa1 Bmyc LOC103692716 Ptges3 Hdac1l Prmt1 Zfp217 Ptges3l1 Esr1 Pou2f1 Cbfb Tle3 Gata3 Fkbp4 Ddx5 Erbb4 Crebbp Nrip1 Pgr Ncoa1 Tbp Runx1 LOC100910200 H2afx Hist1h4b LOC684841 Hist1h2bh Hsp90ab1 LOC100912290 Sp1 Hist1h2ail1 Hist1h4m LOC102549173 Cdk9 LOC103690002 LOC100910152 LOC100912338 Hist1h3c Hdac1 Jun H2afb3 Hist1h3f Hist2h4 LOC684819 Hist1h3a H2afj LOC100911822 Hist2h2aa3 Hist1h2bq Hist2h2aa2 LOC100364835 LOC684762 Fos Ncoa2 Hist1h2bg LOC680097 LOC684797 LOC100912418 Hist1h2ba Hist3h2bb TRIGLYCERIDE METABOLISM%REACTOME%R-RNO-8979227.1 Triglyceride metabolism Fabp3 Fabp6 Fabp1 Fabp4 Gk Fabp12 Pnpla5 Fabp7 Fabp5 Dgat1 Fabp2 Gpam Mogat1 Fabp9 Lpin2 Mogat2 Lpin3 Lpin1 RGD1562200 Dgat2 Gk2 Plin3 Gpat2 Gpd2 Agmo P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME%R-RNO-372708.1 p130Cas linkage to MAPK signaling for integrins Fn1 Src Tln1 Crk Vwf Rap1a Apbb1ip Fgb Bcar1 Fgg Fga Itga2b Ptk2 PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145719 Presynaptic nicotinic acetylcholine receptors Chrnb4 Chrna4 Chrna5 Chrna6 Chrnb2 Chrnb3 Chrne Chrna2 Chrnd Chrna3 Chrna1 PRE-MRNA SPLICING%REACTOME DATABASE ID RELEASE 66%10144828 pre-mRNA splicing Cwc27 Cwc25 Cwc22 Snrpf Wdr33 Ppie RGD1565904 Isy1 Polr2g Polr2h Polr2e Polr2f Polr2j Polr2k Polr2d Polr2i Polr2b Polr2c Polr2a Xab2 LOC100912534 Prpf19 Srsf3 Ccar1 Cdc5l Upf3b U2af2 LOC102548514 Cd2bp2 Papola Srsf6 Elavl1 Srsf7 Ppil6 Prpf38a Srsf4 Srsf5 Srsf2 Hnrnph1 Ppih LOC100359574 Ppil1 Ppil3 Elavl2 Srsf9 Ppil4 Dhx38 LOC100911822 Fblim1 Clp1 Aqr Hnrnph2 Cwc15 Cherp Magoh Hnrpd Ncbp2 Srsf1 LOC100363335 Ctnnbl1 Ppwd1 LOC500684 Ncbp1 LOC680519 Dhx9 Ybx1 LOC100910750 Nhp2l1 Cstf2t Eif4a3 Sympk Bud31 Hnrnpul1 Txnl4a LOC100910660 Hnrnpk Srrm1 Hnrnpu Hnrnpr Wbp4 Usp39 Hnrnpl Snrpa Hnrnpm Hnrnpf Cdc40 Snrpc Hnrnpa2b1 Snrpb Rnps1 Dhx16 Dhx15 Sugp1 Prpf40a Sart1 Snrpb2 Magohb Phf5a Rbm8a Ddx23 Pcf11 Fip1l1 Hnrnpa0 U2surp Nudt21 Snrpd1 Eftud2 LOC100364748 Snrpd2 Snrpd3 Rbm5 Tra2b Sf3b2 Sf3b4 Sf3b3 Pqbp1 Sf3b5 Cstf2 Rbm22 Lsm8 Puf60 Wbp11 Lsm7 U2af1l4 Gtf2f1 Lsm6 Gtf2f2 Lsm4 Lsm3 Lsm5 Cpsf7 Cpsf2 Cpsf3 Cpsf4 Lsm2 Rbm17 Snw1 Cstf1 Snrnp200 Cpsf1 Smptb Gpkow Plrg1 LOC679753 Prpf6 Sf3a3 Sf3b1 Prpf8 Prpf4 Ddx5 Ddx46 Sf3a1 Prpf31 Ddx42 Bcas2 Prpf3 Sf3a2 Crnkl1 LOC100360750 Syf2 Fus Smndc1 Prcc Rbmx LOC100359916 Snrpa1 Snrnp70 BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS%REACTOME DATABASE ID RELEASE 66%10145554 Beta-oxidation of very long chain fatty acids Acot6 Acot4 Acaa1a Acot8 Acaa1b Acox1 Ehhadh Eci3 Hsd17b4 Mlycd Abcd1 PKMTS METHYLATE HISTONE LYSINES%REACTOME DATABASE ID RELEASE 66%10146041 PKMTs methylate histone lysines Rela Hist2h3c2 Setd6 Setd7 Setd8 Setd2 Setd3 Ash1l Suv39h1l1 Rbbp5 Eed LOC100909949 Whsc1 Atf7ip Hist1h4b Prdm9 Wdr5 Kmt2a LOC684841 Smyd2 Setdb1 LOC100911180 LOC100912290 Suv420h2 Rbbp7 LOC686349 Hist1h2ail1 Suv420h1 Hist1h4m Mecom LOC102549173 Ehmt2 Whsc1l1 Ehmt1 Hist1h3c Hist1h3f Hist2h4 LOC684819 Hist1h3a Prdm16 Nsd1 Suv39h1 Suv39h2 LOC100910833 Ash2l Dot1l LOC684762 Dpy30 Nfkb2 Nfkb1 Ezh2 LOC680097 LOC100912418 Aebp2 CHROMATIN MODIFYING ENZYMES%REACTOME%R-RNO-3247509.1 Chromatin modifying enzymes Kdm1a Phf20 Actl6a Mcrs1 Rps2 Setd6 Setd7 Setd8 Setd2 Setd3 Ash1l Suv39h1l1 Rbbp5 Jmjd6 Actl6b Hist1h2aa Smarce1 Pax3 Pbrm1 Arid1b Arid1a Cdk4 Brwd1 Smarcd1 Msl3l2 Smarcd2 Smarcd3 Brpf3 Ccnd1 Kdm2a Brpf1 Brd1 Kdm1b LOC100911453 RGD1310212 Wdr77 Kat6a Ing4 Ing5 Nfkb2 Nfkb1 Prmt3 Padi6 Prmt5 Prmt6 Prmt7 Rela Atf2 Hist1h2bo Kat7 Kansl3 Hist1h2bcl1 Hist2h3c2 Jade1 Hist1h2bk Jade3 Hat1 Kdm4b Carm1 Kdm4a Jade2 Kdm4d Kdm5a Kdm6b Kdm5d Smarca4 Kdm4dl1 Prmt1 Smarca2 LOC100911617 Kat8 Kdm8 Msl3 Kdm3b Kdm3a Arid2 Ogt Smarcc1 Smarcc2 Padi3 Coprs Smarcb1 Padi4 Msl1 Padi1 Ncoa1 Msl2 Meaf6 LOC100909949 Eed Whsc1 LOC100910200 Atf7ip H2afx Hist1h4b Prdm9 Wdr5 Kmt2a LOC684841 Hist1h2bh Smyd2 Setdb1 LOC100911180 LOC100912290 Suv420h2 Rbbp7 LOC686349 Hist1h2ail1 Suv420h1 Hist1h4m LOC102549173 Mecom LOC103690002 Ehmt2 LOC100910152 Whsc1l1 Dnmt3a Ehmt1 LOC100912338 Hist1h3c H2afb3 Hist1h3f Hist2h4 LOC684819 Hist1h3a H2afj Prdm16 Nsd1 Hist2h2aa3 Suv39h1 Hist1h2bq Suv39h2 Hist2h2aa2 LOC100910833 Ash2l Dot1l LOC100364835 Dpy30 LOC684762 Padi2 Ncoa2 Hist1h2bg Ezh2 LOC680097 LOC684797 LOC100912418 Hist1h2ba Hist3h2bb Aebp2 LGI-ADAM INTERACTIONS%REACTOME%R-RNO-5682910.1 LGI-ADAM interactions Adam11 Stx1a Cacng8 Cacng2 Cacng3 Lgi4 Cacng4 Lgi3 Stx1b Lgi1 Dlg4 Adam23 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION%REACTOME DATABASE ID RELEASE 66%10145151 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7 8 or 9 activation Map2k7 Ripk2 Map2k6 Ager Dusp3 Map2k4 Map3k8 Dusp4 Peli3 Nfkbib LOC100912399 Peli2 Map3k1 Traf6 Cul1 Vrk3 Rps6ka2 Rps6ka1 App Rps6ka3 Rps6ka5 Tlr9 LOC100912585 Tab1 Dusp7 Dusp6 Rela Atf1 Atf2 Map3k7 Peli1 Irak2 Nfkbia LOC100910771 Ube2n Jun Ppp2cb Ppp2ca Skp1 Ppp2r1a Nfkb2 Nfkb1 Mapk9 Tlr7 Mapk8 Tlr8 Fos S100b Irak4 Mapk7 Dhx9 Fbxw11 Chuk Ppp2r1b Ecsit Mapkapk3 Btrc Mapkapk2 Mapk1 Nkiras1 LOC100362142 Nod1 Nod2 Nkiras2 Creb1 Tab2 Tab3 LOC100912618 Ube2v1 Ikbkb Mapk14 Myd88 Tnip2 Mapk11 Mapk10 METHIONINE SALVAGE PATHWAY%REACTOME DATABASE ID RELEASE 66%10145821 Methionine salvage pathway Enoph1 Mtap Mri1 Adi1 METABOLISM OF LIPIDS%REACTOME%R-RNO-556833.1 Metabolism of lipids Bche Ache Ncor2 Mtmr4 Smarcd3 Ctsa LOC498300 Vapa Ndufab1 Ppapdc2 Pten Ptgds Pla2g6 Pla2g3 LOC683884 Pla2g5 Pitpnb Helz2 Sc5d Pla2g16 Abcd1 Dpep3 Pla2g15 Dpep1 Pla2g10 Acot6 LOC103689982 Acot4 Lhb Acot8 Nsdhl Acox1 Osbpl5 Osbpl8 Ehhadh Osbpl3 Eci3 Osbpl6 Hsd17b4 Osbpl9 Mlycd Fam73b Osbpl7 Cyp19a1 Fdx1l Ppap2a Sacm1l Prkab2 Ppap2b Slc22a5 Awat1 Awat2 Msmo1 Agps Cpt1b Alpp Alpi Cpt1a Acat2 Acat1 Fig4 LOC100911154 Cpne6 Acp6 LOC100910957 Cpne7 Mcat Cers4 Cers3 Mvd Agk Acot11 Slc25a17 Cers6 Cyp4f17 Tmem86b Lclat1 Acot13 RGD1564865 Tmem55b Slc25a20 Pip4k2b Cga Pip4k2c Cyp4f18 Pik3r5 Bmx Aacs Etnppl Tbxas1 Cept1 Pik3r3 Pik3r6 Cers1 Acer2 Acer1 Acer3 Pi4kb Cyp51 Mut Cers2 Inpp5d Inpp5e Ppt1 Ppt2 Ncoa6 Neu4 Gdf1 Neu2 Slc21a4 Inpp5f Bzrap1 Gltp Tnfaip8l3 B4galnt1 Dgat2l6 Neu3 Cerk Tnfaip8l1 Abcb11 Enpp7 Inpp5j Gba Tnfaip8 Galc Tnfaip8l2 Asah2 Stard3nl Vapb Rufy1 Ormdl1 Acox3 Ptdss2 Acox2 Srd5a3 Cdipt Aldh3a2 Sin3a Sin3b Cyp4f6 Ormdl2 Mapkapk2 LOC317456 Ppap2c Prkaa2 Osbpl10 Cbr1 Tspo Crls1 LOC100912391 Cpt2 Cyp24a1 Mcee Srd5a1 Srd5a2 Pmvk Srebf1 Pik3c2a Pik3c2b Srebf2 Pik3c2g Cds2 Hmgcll1 Cyp4a2 Pla2r1 Sqle Cyp4a1 Ptgis Tpte2 Pla2g4e Pla2g4b Lgmn Pla2g4d Inpp4a Rxra Aloxe3 Cyp4a8 Inpp4b LOC100912469 Pctp Pla2g4a Cds1 Cbr4 Acot7 Acot9 Pla2g4c Acot2 Cyp2j10 Acot5 Fdft1 Acss3 Nr1h4 Enpp6 Cyp1b1 Mbtps1 Cidec Tecr Mbtps2 Sgpl1 Echs1 Nudt7 Sbf1 Ptpn13 Hdac3 LOC100365676 Hsd17b3 Hsd17b8 Csnk2a2 Acsbg1 Hsd17b1 Hsd17b2 Pla2g12a Far2 Far1 Csnk2a1 Stard7 Stard6 Acoxl Stard3 Fa2h RGD1562948 Gc Acsbg2 Alox5ap Sptssb Lpcat4 Sptssa Eci1 Stard4 Stard5 Lpcat1 Plbd1 Abhd4 Akr1c12l1 Lipi Mid1ip1 Baat Cyp46a1 Lpcat3 Lpcat2 Fitm1 Fitm2 Hpgds Gnpat Akr1c19 Vac14 Abhd3 Thrsp Tbl1x Hsd3b Akr1c13 Akr1c14 LOC681458 Akr1c12 Pla2g4cl1 Fasn Chat Csnk1g2 Amacr Hexb Akr1d1 Hexa Cyp4f39 Cyp39a1 Pomc Pld2 Vdr Pld6 Cyp2d5 Tecrl Synj1 Scap Fdx1 Plekha4 Plekha3 Plekha5 Pon3 Cubn Pon1 Pon2 Plekha8 Degs2 Synj2 Plekha1 Hsd3b1 Alppl2 Hsd3b2 Pik3cd Pik3cg Hsd3b7 Acadvl Acsl3 Acsl1 Hpgd Acsl6 Acsl5 Acsl4 Agpat1 LOC100361547 Gpx4 Agpat4 Cyp3a23/3a1 Agpat3 Ch25h Cyp3a73 RGD1564347 Pnpla8 Agpat9 Acaa2 Cyp2u1 Agpat6 Agpat5 Etnk1 Fabp2 Cyp2c7 Pnpla3 Alox15b Gpam Alox12 Mogat1 Pnpla2 Cyp2e1 Glb1 Fabp9 Pnpla6 Ltc4s Samd8 Lpin2 Gstm4 Mogat2 Cyp2d4 Acbd7 Cyp3a18 Acad10 Lpin3 Acad11 Lpin1 Cyp1a1 LOC100910877 Ptgs1 RGD1562200 Cyp2d2 Acbd5 Dgat2 Gk2 Hacl1 Ptgs2 Acbd6 Ephx2 Plin3 Gpat2 Dhcr24 Cyp1a2 Mmaa Gpd2 Alox15 Cyp2d3 Acbd4 Pi4k2b Cyp2c6v1 Agmo Slco1a1 Ddhd2 Ddhd1 Arv1 Slc44a4 Phyh Slco1a4 Slco1a2 Slc44a5 Mboat1 RGD1306195 Slc44a3 Hmgcl Slco1b2 Mboat7 LOC688708 Akr1b7 Akr1b8 Kdsr Mtmr14 LOC102556347 Ppara Mtmr12 Taz Ppard Star Acadl Hmgcs2 Acads Cyp7b1 Acadm Sgpp2 Pip5k1c Hrasls5 Pi4k2a Pip5k1b Pip5k1a Hmgcs1 Akr1c2 Scd4 Hao2 Akr1c3 Cyp7a1 Tm7sf2 Cyp21a1 Fdxr Pcyt1b Pcyt1a Tgs1 LOC100911186 Them5 Acsf2 Cyp2r1 Scd1 Scd2 Acsf3 Pitpnm1 Dbi Pitpnm3 Pitpnm2 Morc2 Ocrl Akr1c1 LOC100911941 Stard10 Osbp Fads1 Pcyt2 Mtmr9 Mtmr6 Mtmr7 Mtmr2 Ggps1 Dpep2 Ptges Tbl1xr1 Faah Pla2g2a Pla2g2f Pla2g2d Gpd1l Pla2g1b LOC686302 Elovl1 LOC100911615 Elovl5 Slc25a1 Elovl2 Elovl3 Crot Slc27a5 Chka Mtmr3 Mfsd2a Mtmr1 Elovl6 Cyp11b2 Sgms1 Cyp27b1 Morc2b Decr1 Slco1a6 Pik3c3 Hacd1 Ncoa2 Phospho1 Dhcr7 Glb1l Bdh2 Hadh Akr1b1 Sphk2 Arsb Lpgat1 Pik3r4 Hadha Col4a3bp Hadhb Cyp8b1 Gpd1 Hsd17b14 Slc10a1 Hmgcr Ebp Pemt Crat Pccb Hacd4 Hacd3 Pikfyve Hsd11b2 Hsd17b13 Slc10a2 Hsd17b12 Hsd17b11 Psap Acly Cpne3 Fabp5 Aldh3b1 Cpne1 RGD1564463 Ptges2 Alox5 Neu1 Lta4h Arsi Smpd1 Arse Cptp Arsg Smpd2 Esyt3 Smpd3 Arsk Sts Esyt2 Slc27a2 Smpd4 Dgat1 Gba2 Sumf2 Sumf1 B3galnt1 Ugt8 Ugcg Gm2a Kpnb1 Pld1 Med1 Fabp3 Fabp6 Fabp1 LOC100910990 Fabp4 Gk Fabp12 Pnpla5 Fabp7 Mgll Arsa Acaa1a Acaa1b Carm1 Slc44a2 Ptges3 Ptges3l1 Them4 Crebbp Rbm12 Ncoa1 Asah1 Pik3r1 Pik3r2 Sptlc3 Sptlc1 Prkd3 Sptlc2 Prkd1 Prkd2 Oxct1 Csnk2b Gla Pik3cb Agpat2 Degs1 INWARDLY RECTIFYING K+ CHANNELS%REACTOME DATABASE ID RELEASE 66%10145793 Inwardly rectifying K+ channels Kcnj4 Kcnj6 Gnb3 Kcnj16 Gnb2 Gnb1 Gng12 Kcnj2 Kcnj3 Kcnj11 Kcnj14 Kcnj15 Kcnj9 Abcc8 Gng4 Kcnj5 Gngt2 Kcnj8 Gabbr1 Gng5 Kcnj12 Gngt1 Gng8 Gabbr2 Gng10 Abcc9 Gng3 TFAP2 (AP-2) FAMILY REGULATES TRANSCRIPTION OF GROWTH FACTORS AND THEIR RECEPTORS%REACTOME%R-RNO-8866910.1 TFAP2 (AP-2) family regulates transcription of growth factors and their receptors Atad2 Lhb Esr1 Cga SIGNALING BY ROBO RECEPTORS%REACTOME%R-RNO-376176.1 Signaling by ROBO receptors Evl LOC100909750 Cxcl12 Rhoa Pfn1 Robo2 Pfn2 Robo3 Prkca Akap5 Enah Myo9b LOC100909840 Vasp Dag1 Abl2 Gpc1 Robo1 Cxcr4 Usp33 Slit3 Abl1 Slit2 ORGANIC ANION TRANSPORTERS%REACTOME DATABASE ID RELEASE 66%10145484 Organic anion transporters Slc5a5 Slc5a8 Slc25a22 Slc17a5 Slc17a6 Slc17a7 Slc17a8 Slc25a10 LOC100911440 Slc25a18 AXONAL GROWTH INHIBITION (RHOA ACTIVATION)%REACTOME%R-RNO-193634.1 Axonal growth inhibition (RHOA activation) Rhoa Arhgdia Rtn4 Lingo1 Ngfr Omg Mag DOWNREGULATION OF ERBB2 SIGNALING%REACTOME%R-RNO-8863795.1 Downregulation of ERBB2 signaling Ptpn18 Ereg Rnf41 Nrg1 Btc LOC102552659 Erbb3 Erbb2 Nrg3 Matk Egfr LOC103692716 Hbegf Akt1 Nrg4 Akt3 Erbb4 Ptpn12 Usp8 Akt2 Nrg2 Stub1 ROS, RNS PRODUCTION IN PHAGOCYTES%REACTOME DATABASE ID RELEASE 66%10145602 ROS, RNS production in phagocytes Atp6v1d Slc11a1 Tcirg1 Atp6v0d1 Atp6v1c2 Nos3 Atp6v0d2 Atp6v1a Atp6v0e2 Atp6v0e1 Atp6v1g3 Atp6v1e1 Atp6v1e2 Atp6v1c1 Nos1 Atp6v1g1 Atp6v1g2 Atp6v0a4 Atp6v0a1 Atp6v1b2 Atp6v0a2 Atp6v1h Atp6v1f LOC497963 Ncf1 Ncf4 Cybb Cyba Atp6v0c GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME%R-RNO-354194.1 GRB2:SOS provides linkage to MAPK signaling for Integrins Fn1 Src Tln1 Vwf Rap1a Apbb1ip Fgb Fgg Fga Itga2b Ptk2 Sos1 Grb2 AMPLIFICATION OF SIGNAL FROM UNATTACHED KINETOCHORES VIA A MAD2 INHIBITORY SIGNAL%REACTOME DATABASE ID RELEASE 66%10145062 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Cenpn Zwilch Cenpl Nup43 Cenpo Nup98 Nup133 Dync1li2 Nup107 Cenpt Cenpu Bub3 Bub1 Spdl1 Kntc1 Dync1i2 Mad1l1 Cenpk Cenph Nup37 Cenpi Cenpf Cenpe Cenpm Ahctf1 Ndel1 Cdca8 Dync1h1 Rcc2 Pafah1b1 Dync1li1 Rangap1 Mis12 Ppp1cc LOC100909468 Aurkb Dynll2 Ndc80 Sec13 Cenpc Xpo1 Cenpa Dync1i1 LOC100911204 Ranbp2 Spc24 Spc25 Birc5 Taok1 Itgb3bp Sgol2 Ppp2r5e Incenp Nsl1 B9d2 Cdc20 Kif2a Kif2c Kif2b Bub1b Kif18a Ppp2r5c Ppp2cb Ppp2r5a Ppp2ca Ppp2r1a Ppp2r5b Zwint Dsn1 Mad2l1 Nup85 Casc5 Clasp2 Ercc6l Nuf2 Clasp1 LOC679582 Ppp2r1b Mapre1 Pmf1 Ckap5 Ska2 Sgol1 Zw10 Ska1 GDP-FUCOSE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 66%10145727 GDP-fucose biosynthesis Fuom Slc35c1 Fuk Tsta3 Gmds LOC100911225 Fpgt REGULATION OF SIGNALING BY CBL%REACTOME%R-RNO-912631.1 Regulation of signaling by CBL Fyn Pik3r3 Pik3r1 Crk Pik3r2 Cbl Pik3cb Lyn Crkl Yes1 Vav1 Pik3cd Hck Rapgef1 Syk LOC100911248 Grb2 CALNEXIN CALRETICULIN CYCLE%REACTOME DATABASE ID RELEASE 66%10145711 Calnexin calreticulin cycle Edem3 Calr Man1b1 Rnf139 Ganab Edem2 Uggt1 Trim13 Rnf5 Prkcsh Canx Rnf103 March6 Os9 Sel1l COLLAGEN CHAIN TRIMERIZATION%REACTOME DATABASE ID RELEASE 66%10145922 Collagen chain trimerization Col20a1 Col19a1 Col13a1 LOC100910384 Col8a1 Col8a2 Col3a1 Col28a1 Col1a1 Col22a1 Col1a2 Col16a1 Col18a1 Col5a2 Col5a1 Col9a1 Col27a1 Col9a2 Col11a2 Col9a3 Col11a1 Col5a3 Col26a1 Col14a1 Col7a1 Col23a1 Col17a1 SHC-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%R-RNO-2428933.1 SHC-related events triggered by IGF1R Igf2 Igf1 Sos1 Shc1 Grb2 RAS ACTIVATION UPON CA2+ INFLUX THROUGH NMDA RECEPTOR%REACTOME%R-RNO-442982.1 Ras activation upon Ca2+ influx through NMDA receptor Grin2d Camk2g Grin2b Grin1 Nefl Rasgrf1 Dlg1 Dlg2 Dlg3 Camk2d Actn2 Camk2a Lrrc7 Hras Dlg4 FRS-MEDIATED FGFR1 SIGNALING%REACTOME DATABASE ID RELEASE 66%10146102 FRS-mediated FGFR1 signaling Kras Frs3 Fgf23 Fgf22 Fgf4 Fgf1 Fgf3 Fgf6 Fgf5 Fgf20 Fgf16 Fgf17 Fgf10 Fgf9 Fgfr2 Fgf7 Fgf2 Fgf8 Fgfr3 Fgfr1 Fgfr4 Ptpn11 Fgf19 Hras Nras Sos1 Frs2 Grb2 MASTL FACILITATES MITOTIC PROGRESSION%REACTOME%R-RNO-2465910.1 MASTL Facilitates Mitotic Progression Ensa Arpp19 SYNTHESIS OF PE%REACTOME%R-RNO-1483213.1 Synthesis of PE Etnppl Pcyt2 Lpin2 Cept1 Lpin3 Phospho1 Lpin1 Chka Etnk1 INOSITOL TRANSPORTERS%REACTOME DATABASE ID RELEASE 66%10145635 Inositol transporters Slc5a11 Slc2a13 PHOSPHOLIPID METABOLISM%REACTOME%R-RNO-1483257.1 Phospholipid metabolism Enpp6 Pten Pla2g6 Pla2g3 Pla2g5 Pitpnb Sbf1 Ptpn13 Pla2g16 Pla2g15 Pla2g10 LOC103689982 Csnk2a2 Cpne3 Osbpl5 Osbpl8 Pla2g12a Csnk2a1 Fam73b Stard7 Sacm1l Awat2 Lpcat4 Alpp Alpi Lpcat1 Plbd1 Abhd4 Fig4 Lipi Cpne6 Acp6 Lpcat3 Cpne7 Cpne1 Lpcat2 Gnpat Agk Vac14 Abhd3 Tmem86b Lclat1 Tmem55b Pip4k2b Bche Pip4k2c Pla2g4cl1 Chat Pik3r5 Bmx Ache Etnppl Cept1 Pik3r3 Pld2 Pik3r6 Pld6 Synj1 Pi4kb Mtmr4 Plekha4 Plekha3 Plekha5 Inpp5d Inpp5e Plekha8 Synj2 Plekha1 Inpp5f Alppl2 Tnfaip8l3 Dgat2l6 Pik3cd Tnfaip8l1 Pik3cg Inpp5j Tnfaip8 Tnfaip8l2 Rufy1 Agpat1 Agpat4 Ptdss2 Agpat3 Cdipt Pnpla8 Agpat9 Dgat1 Agpat6 Agpat5 LOC317456 Etnk1 Pnpla3 Osbpl10 Gpam Pnpla2 Pnpla6 Crls1 Lpin2 Lpin3 Lpin1 Dgat2 Gpat2 Pik3c2a Gpd2 Pik3c2b Pi4k2b Pik3c2g Cds2 Ddhd2 Ddhd1 Pla2r1 Slc44a4 Pld1 Tpte2 Pla2g4e Slc44a5 Pla2g4b Mboat1 Pla2g4d Slc44a3 Inpp4a Mboat7 Inpp4b Pctp Pla2g4a LOC100910990 Cds1 Mtmr14 Mtmr12 Pla2g4c Taz Mgll Pip5k1c Hrasls5 Pi4k2a Pip5k1b Pip5k1a Slc44a2 Pcyt1b Pcyt1a Pitpnm1 Pitpnm3 Pitpnm2 Rbm12 Ocrl Stard10 Pcyt2 Mtmr9 Mtmr6 Mtmr7 Pik3r1 Pik3r2 Mtmr2 Pla2g2a Pla2g2f Pla2g2d Gpd1l Pla2g1b LOC686302 LOC100911615 Chka Mtmr3 Mfsd2a Mtmr1 Csnk2b Pik3c3 Phospho1 Lpgat1 Hadha Pik3r4 Hadhb Gpd1 Pik3cb Agpat2 Pemt Pikfyve BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN%REACTOME%R-RNO-446193.1 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein Ctsa Mvd Fuom Slc35c1 Fuk Tsta3 Gmds LOC100911225 Fpgt St8sia1 Alg1 Gfpt2 Nus1 Alg2 Neu4 Dolpp1 Neu2 Gfpt1 St8sia3 Alg6 Alg3 Alg9 Neu3 Alg8 Neu1 Renbp St3gal5 Mpi Pgm3 Pmm2 Alg14 Pmm1 Srd5a3 Alg12 Nans Slc35a1 St8sia5 Slc17a5 St6galnac1 St6galnac2 Nudt14 Npl LOC501189 Dhdds St8sia4 Cmas LOC100910177 Nanp Dolk St6gal1 Glb1 St6gal2 Amdhd2 St6galnac4 St3gal2 St6galnac3 St3gal3 Nagk Gne Mpdu1 St3gal1 Dpagt1 St6galnac6 Gnpnat1 Dpm3 Dpm2 St3gal4 Dpm1 St3gal6 Uap1 BBSOME-MEDIATED CARGO-TARGETING TO CILIUM%REACTOME DATABASE ID RELEASE 66%10146078 BBSome-mediated cargo-targeting to cilium Ttc8 Bbs9 Bbs1 Bbs2 Smo Mchr1 Arl6 Rab3ip Lztfl1 Sstr3 Bbs7 Bbs5 Bbs4 ACYL CHAIN REMODELLING OF PE%REACTOME%R-RNO-1482839.1 Acyl chain remodelling of PE Pla2r1 Pla2g6 Pla2g3 Pla2g5 Pla2g4e Mboat1 Pla2g4b Pla2g4d Pla2g16 Pla2g2a Pla2g2f Pla2g10 Pla2g2d Pla2g1b LOC686302 Pla2g4a Pla2g12a Pla2g4c Hrasls5 Lpcat4 Plbd1 Abhd4 Pnpla8 Lpcat3 Pla2g4cl1 RESOLUTION OF ABASIC SITES (AP SITES)%REACTOME%R-RNO-73933.1 Resolution of Abasic Sites (AP sites) Rfc1 Rfc2 Pole2 Pole4 Rpa1 Rpa2 Lig1 Tdg Mpg Neil1 Ogg1 Xrcc1 Neil2 Mbd4 Parp2 Smug1 Rpa3 Parp1 Pnkp Lig3 LOC100911727 Pole Polb Pold2 Nthl1 Pcna Pold1 Mutyh Pold4 Fen1 Adprhl2 Ung Parg Rfc5 Apex1 Rfc4 Rfc3 ACTIVATION OF AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145580 Activation of AMPA receptors Gria3 Gria4 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS%REACTOME%R-RNO-2122948.1 Activated NOTCH1 Transmits Signal to the Nucleus Notch1 Dtx2 Dtx4 Dtx1 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX)%REACTOME DATABASE ID RELEASE 66%10145441 Synthesis of Leukotrienes (LT) and Eoxins (EX) Alox5ap Cyp4a2 Cyp4f39 Cyp4a1 Dpep2 Dpep3 Cyp4f6 Cyp4a8 Mapkapk2 Dpep1 LOC688708 Ltc4s LOC100912391 Alox5 Cyp4f17 Alox15 Lta4h Cyp4f18 METABOLISM OF VITAMIN K%REACTOME%R-RNO-6806664.1 Metabolism of vitamin K Ubiad1 OVARIAN TUMOR DOMAIN PROTEASES%REACTOME%R-RNO-5689896.1 Ovarian tumor domain proteases Ripk2 Pten Apc Otub1 Otud3 Otud7b Ube2d1 LOC100910954 Cdk1 Traf6 Traf3 Vcp Esr1 Nod1 Nod2 Rhoa Zranb1 Ripk1 Vcpip1 Tnip1 Tnip2 Otub2 Tnfaip3 TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G2 CELL CYCLE ARREST%REACTOME DATABASE ID RELEASE 66%10146160 TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest Gadd45a Bax Sfn Cdk1 Aurka Pcna EPHB-MEDIATED FORWARD SIGNALING%REACTOME DATABASE ID RELEASE 66%10146024 EPHB-mediated forward signaling Grin2b Arpc4 Grin1 Src Rock1 Arpc3 Itsn1 Potef Rac1 Kalrn LOC100361457 Rock2 Sdc2 Actr3 Actr2 Arpc1b Fyn Actb Tiam1 Kdr LOC103692716 Cdc42 Vegfa Rhoa Arpc5 Pak1 Wasl Lyn Hras Ptk2 Yes1 Actg1 Rasa1 Shb Arhgef28 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS%REACTOME DATABASE ID RELEASE 66%10145068 APC C-mediated degradation of cell cycle proteins Psmc6 Psmb10 Psmb8 Psmb9 Psmb4 Psmb11 Bub3 Psmb5 Psmf1 Psmb6 Psmd4 Psmb2 Cul1 Psmd5 Psmd8 Psmd9 Psmb3 Psma8 Psmd11 Psmd12 Ccna2 Anapc11 Ccna1 Anapc15 Aurka Psmd13 Psmd14 Anapc10 Fzr1 Fbxo5 Cdk2 Aurkb Psmc3 G6pc Ube2d1 Cdc20 Psmb7 Psmb1 Bub1b Skp1 Mad2l1 Anapc7 Cdc26 Cdc14a Cdc27 Cdc23 Psma5 Pttg1 Ube2c Skp2 Cdkn1a Cdkn1b Cdk1 Anapc16 Cdc16 Nek2l1 Btrc Anapc4 Anapc2 Psma2 Anapc1 Psmc5 Psmd2 Psma1 Psma4 Psmc1 Psma3 Psmc4 Psmc2 Psma6 Psme1 Nek2 Psmd1 Psme2 Psmd7 Psmd3 Psmd6 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT%REACTOME DATABASE ID RELEASE 66%10144783 The citric acid (TCA) cycle and respiratory electron transport Mt-nd4 Ndufab1 Atp5f1 Ndufa7l Mt-nd5 Etfa Mdh2 Etfb LOC683884 Idh3g Mt-nd6 Nubpl Mt-nd2 Glo1 Idh2 LOC100911483 Cs Ndufb10 Ndufb11 Ndufa12 Ndufa11 Mt-atp6 Ndufa13 Ndufa10 Sucla2 Slc16a3 Slc16a8 Slc16a1 Ndufc2 Bsg Ucp2 Ecsit Ucp3 LOC100909612 Slc25a14 Ucp1 Ndufaf7 Ndufa7 Ndufaf5 Rxra Ppard Ldha Ndufb6 Ndufb3 LOC100912599 Ndufb5 Vdac1 Ldhb LOC100361505 Me2 Hagh Fahd1 Me3 Ndufb9 Ndufb4 Ndufb8 Ndufb7 Sdhc Sdhd Ndufaf3 Sdha Me1 Atp5j2 Dlst Ndufaf1 Ndufa2 Ndufa5 Ndufaf4 Ndufa6 Mt-atp8 Sdhb RGD1306782 Ndufa1 Ndufs3 LOC500350 Ndufs1 Ogdh Ndufs4 Atp5g3 Ndufs5 Ndufs2 Ndufs8 Coq10a Ndufs6 Ndufs7 Pdpr Timmdc1 Pdhb Atp5g2 Pdk3 Pdk4 Pdk1 Pdk2 LOC100365902 LOC684509 Pdha2 Pdha1 Pdhx Pdha1l1 Acad9 Suclg2 Ndufb2 Ldhc Nnt LOC679739 LOC100911417 Idh3a Etfdh Gstz1 LOC679195 D2hgdh Pdp1 LOC100910710 Aco2 LOC680288 Adhfe1 Idh3B LOC688963 Dlat L2hgdh Atp5l Atp5o Atp5h Tmem126b Atp5i Atp5j LOC100363268 Ndufv3 LOC100361144 Ndufv1 Ndufv2 Atp5s Atp5e Atp5d Fh Atp5b Dld BIOTIN TRANSPORT AND METABOLISM%REACTOME DATABASE ID RELEASE 66%10145370 Biotin transport and metabolism Acacb Slc5a6 Mccc2 Pdzd11 Hlcs Pccb Mccc1 Pc SHC-MEDIATED CASCADE:FGFR1%REACTOME DATABASE ID RELEASE 66%10146109 SHC-mediated cascade:FGFR1 Kras Fgf17 Fgf10 Fgf9 Fgf2 Fgf8 Fgfr1 Fgf23 Fgf22 Fgf4 Fgf1 Fgf3 Fgf6 Fgf5 Hras Nras Sos1 Shc1 Fgf20 Grb2 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE%REACTOME%R-RNO-77075.1 RNA Pol II CTD phosphorylation and interaction with CE Gtf2h1 Gtf2h2 Mnat1 RGD1565904 Ercc3 Polr2g Polr2h Polr2e Polr2f Polr2j Polr2k Polr2d Supt5h LOC100911822 Polr2i Polr2b Polr2c Ercc2 Polr2a Rnmt Rngtt LOC100912534 Gtf2f1 Gtf2f2 Cdk7 Ccnh Gtf2h3 Gtf2h5 Gtf2h4 AMINO ACID CONJUGATION%REACTOME DATABASE ID RELEASE 66%10145091 Amino Acid conjugation Glyatl3 Acsm1 Glyat ALPHA-LINOLENIC ACID (ALA) METABOLISM%REACTOME%R-RNO-2046106.1 alpha-linolenic acid (ALA) metabolism Acsl1 Acaa1a Acot8 Fads1 Acaa1b Acox1 Elovl1 Elovl5 Hsd17b4 Elovl2 Elovl3 Abcd1 THE PHOTOTRANSDUCTION CASCADE%REACTOME DATABASE ID RELEASE 66%10144866 The phototransduction cascade Cnga1 Gucy2f Pde6b Rcvrn Gucy2d Pde6a Rgs9 RGD1560341 Gnb5 Gnb1 Guca1b Ppef1 Metap2 Metap1 Gnat1 Nmt1 Guca1a Cngb1 Rgs9bp Fnta Nmt2 Sag Grk4 Grk1 Gngt1 Fntb Pde6g MITOCHONDRIAL FATTY ACID BETA-OXIDATION%REACTOME%R-RNO-77289.1 Mitochondrial Fatty Acid Beta-Oxidation Ndufab1 LOC683884 Echs1 Mut Pctp Acot7 Acot9 Acadl Acot2 Acads Acot5 Acadm Acadvl Decr1 Eci1 Hadh Acaa2 Hadha Hadhb Mcat LOC100911186 Them5 Acsf2 Acot11 Acbd7 Acad10 Pccb Acad11 Mcee Them4 Dbi Acot13 Acbd6 Mmaa SULFUR AMINO ACID METABOLISM%REACTOME%R-RNO-1614635.1 Sulfur amino acid metabolism Mpst Txn2 Suox Cbs Sqrdl Mtrr Bhmt2 Ethe1 Enoph1 Mtap Mri1 Mtr Adi1 Cdo1 Cth Tstd1 Tst Mat1a Slc25a10 Ahcy NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 66%10145481 Norepinephrine Neurotransmitter Release Cycle Rab3a Rims1 Stx1a Cplx1 Syt1 Maoa Vamp2 Stxbp1 Ppfia1 Ppfia2 Ppfia3 Ppfia4 Slc22a1 Bzrap1 Slc22a2 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145954 Binding and Uptake of Ligands by Scavenger Receptors LOC685953 Cd36 Stab2 Sparc Scarb1 Apol2 Hsp90b1 Colec12 RGD1309808 Scgb3a2 Apoa1 Cd163 Hbb-b1 Apol11a Apol3 Hpx Msr1 LOC100910885 Apol9a Calr Marco Hba1 Ambp Lrp1 RGD1565355 LOC287167 Apob Apoe FCERI MEDIATED CA+2 MOBILIZATION%REACTOME%R-RNO-2871809.1 FCERI mediated Ca+2 mobilization Vav3 RGD1560225 Ppp3ca Nfatc2 Tec Txk Lat Plcg1 Lyn Ppp3r1 Vav2 Sos1 Vav1 Nfatc3 Lcp2 Shc1 Syk Itk Grb2 BIOSYNTHESIS OF ELECTROPHILIC Ω-3 PUFA OXO-DERIVATIVES%REACTOME DATABASE ID RELEASE 66%10146319 Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives Alox5 Ptgs2 PTEN REGULATION%REACTOME%R-RNO-6807070.1 PTEN Regulation Psmc6 Pten Psmb10 Usp7 Trim27 Psmb8 Psmb9 Psmb4 Psmb11 Psmb5 Psmf1 Psmb6 Psmd4 Psmb2 Psmd5 Psmd8 Csnk2a2 Psmd9 Psmb3 Psma8 Psmd11 Csnk2a1 Psmd12 Pml Psmd13 RragB Psmd14 Psmc3 Akt1 Hdac1 Xiap Tnks Phc1 Stub1 Phc2 Mtor Rheb Rptor Lamtor4 Lamtor5 Mlst8 Rraga Rragc Akt3 Rragd Slc38a9 Otud3 Lamtor3 Sall4 Scmh1 Cbx4 Cbx2 Cbx8 Lamtor2 Cbx6 Lamtor1 Bmi1 Hdac2 Rnf2 Mbd3 Usp13 Ring1 Hdac1l Chd3 Chd4 Phc3 Prex2 Mta3 Tnks2 Mta1 Mta2 Gatad2a LOC100910717 Maf1 Gatad2b Akt2 Eed G6pc Rbbp7 Mecom Frk Psmb7 Psmb1 Csnk2b Psma5 Psma2 Psmc5 Psma1 Psmd2 Psma4 Psmc1 Psma3 Psmc4 Psma6 Psmc2 Psme1 Ezh2 Psmd1 Psme2 Psmd7 Psmd3 Psmd6 TFAP2A ACTS AS A TRANSCRIPTIONAL REPRESSOR DURING RETINOIC ACID INDUCED CELL DIFFERENTIATION%REACTOME%R-RNO-8869496.1 TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation Tfap2a SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1)%REACTOME DATABASE ID RELEASE 66%10145538 Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Gnat3 Dpp4 Lep Grp Gpr119 Ffar4 Gnb3 Gcg Ffar1 Gng13 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE%REACTOME DATABASE ID RELEASE 66%10145130 Toll Like Receptor 4 (TLR4) Cascade Map2k7 Ripk2 Tbk1 Itgam Map2k6 Ager Dusp3 Irf3 Map2k4 Map3k8 Dusp4 Peli3 Nfkbib LOC100912399 Peli2 Map3k1 Traf6 Cul1 Vrk3 Rps6ka2 Itgb2 Rps6ka1 App Rps6ka3 Rps6ka5 Bpi Tirap LOC100912585 Tab1 Dusp7 Dusp6 Rela Atf1 Atf2 Map3k7 Peli1 Irak2 Tlr4 Ikbke Tank Traf3 Nfkbia LOC100910771 Ube2n Lbp Ptpn4 Jun Ppp2cb Ppp2ca Skp1 Ppp2r1a Ticam2 Nfkb2 Cd14 Nfkb1 Mapk9 Mapk8 Fos S100b Mapk7 Dhx9 Fbxw11 Chuk Ppp2r1b Ecsit Mapkapk3 Btrc Mapkapk2 Mapk1 Nkiras1 LOC100362142 Nod1 Ptpn11 Nod2 Nkiras2 Creb1 Tab2 Tab3 LOC100912618 Ube2v1 Ikbkb Mapk14 Myd88 Tnip2 Mapk11 Mapk10 ADENYLATE CYCLASE ACTIVATING PATHWAY%REACTOME DATABASE ID RELEASE 66%10145191 Adenylate cyclase activating pathway Adcy8 Adcy9 Adcy5 Adcy3 Adcy4 Adcy7 Adcy6 Gnal SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL%REACTOME DATABASE ID RELEASE 66%10145908 Synthesis of pyrophosphates in the cytosol Nudt11 LOC100912928 Nudt3 Ppip5k1 Ppip5k2 Nudt10 Ip6k1 Ippk Nudt4 Itpk1 NEGATIVE REGULATION OF ACTIVITY OF TFAP2 (AP-2) FAMILY TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 66%10146003 Negative regulation of activity of TFAP2 (AP-2) family transcription factors Sumo1 Tfap2b Ube2i Tfap2c Tfap2a Tfap2d Tfap2e VLDL CLEARANCE%REACTOME DATABASE ID RELEASE 66%10146224 VLDL clearance Apobr Apob Vldlr Apoc1 LOC100910181 Apoc4 RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF HSCS%REACTOME DATABASE ID RELEASE 66%10146239 RUNX1 regulates transcription of genes involved in differentiation of HSCs Psmc6 Psmb10 Psmb8 Psmb9 Psmb4 Psmb11 Psmb5 Psmf1 Psmb6 Psmd4 Mnat1 Psmb2 Psmd5 Psmd8 Psmd9 Psmb3 Gata2 LOC100911167 Psma8 Psmd11 Psmd12 Tal1 Ldb1 Psmd13 Psmd14 Tp73 Gata1 Lmo2 Lmo1 LOC100909750 Psmc3 Ccnh Cbfb Yap1 Gata3 Abl1 Runx1 Kmt2a G6pc Psmb7 Psmb1 Psma5 Cdk7 Psma2 Psmc5 Psmd2 Psma1 Psma4 Psmc1 Psma3 Psmc4 Psmc2 Psma6 Psme1 Psmd1 Psme2 Psmd7 Psmd3 Psmd6 BIOSYNTHESIS OF DPAN-6 SPMS%REACTOME DATABASE ID RELEASE 66%10146307 Biosynthesis of DPAn-6 SPMs Alox12 Alox15 GROWTH HORMONE RECEPTOR SIGNALING%REACTOME DATABASE ID RELEASE 66%10145708 Growth hormone receptor signaling Stat5a Prl Sh2b1 Lyn Ptpn1 Gh1 Ghr Mapk1 REUPTAKE OF GABA%REACTOME%R-RNO-888593.1 Reuptake of GABA Slc6a11 Slc6a13 Slc6a1 Slc6a12 THYROXINE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 66%10145424 Thyroxine biosynthesis Slc5a5 Tpo Iyd Duox2 Duox1 Tshb Cga PLATELET ADHESION TO EXPOSED COLLAGEN%REACTOME%R-RNO-75892.1 Platelet Adhesion to exposed collagen Gp1ba Gp9 Fyn Gp5 Gp1bb LOC100911551 Lyn Vwf Fcer1g INITIAL TRIGGERING OF COMPLEMENT%REACTOME%R-RNO-166663.1 Initial triggering of complement C1s C1r Masp2 C1qb Colec10 Cfd C4a Colec11 C1qa C4b C3 LOC100909666 Gzmm LOC102549354 C2 FORMATION OF THE CORNIFIED ENVELOPE%REACTOME%R-RNO-6809371.1 Formation of the cornified envelope Tgm1 LOC100910942 Dsg4 Klk8 Dsg3 Dsg2 Dsc3 Ivl Spink5 Dsc2 Spink6 LOC684499 LOC100910851 Jup Rptn LOC100911681 Lipk Lipm LOC100360690 LOC689230 Stfa2l1 Stfa2l3 Stfa2l2 Dsp Dsg1 RGD1565682 Pkp1 Pkp4 Pkp3 Sprr3 Klk12 Klk13 Klk14 Stfa3l1 Casp14 Stfa3 Evpl Csta LOC100911797 Ppl Perp Cela2a LOC100362978 SIGNALING BY MET%REACTOME%R-RNO-6806834.1 Signaling by MET Ptpn1 Stat3 Rac1 Lamc1 Lamc2 Gab1 Cbl Arf6 Spint1 Gga3 Hgf Ptpn2 Stam2 Sh3gl2 Sh3gl1 Spint2 Sh3kbp1 Lamb1 Muc20 Hgfac Ptk2 Sh3gl3 Ranbp10 Lamb2 Tns4 Lamb3 Lrig1 Usp8 Stam Rab4a Kras Src Pik3r1 Ptprj Dock7 Ranbp9 Rab4b Crk Rap1a Itga3 Lama4 Ptpn11 Crkl Hras Nras Sos1 Lama1 Rapgef1 Shc1 LOC100911248 Grb2 RHO GTPASES ACTIVATE FORMINS%REACTOME%R-RNO-5663220.1 RHO GTPases Activate Formins Cenpn Zwilch Cenpl Nup43 Cenpo Nup133 Dync1li2 Cenpt Cenpu Bub3 Bub1 Potef Rac1 Spdl1 Kntc1 Dync1i2 Mad1l1 Cenpk Cenph Cenpi Nup37 Cenpf Cenpe Cenpm Ahctf1 Ndel1 Rcc2 Actb Pafah1b1 LOC100361515 Mis12 Dynll2 Diaph1 Ndc80 Cenpc Cenpa Dync1i1 Daam1 Srgap2 LOC100909840 Ranbp2 Actg1 Birc5 Taok1 Src Ppp2cb Ppp2ca Ppp2r1a Nup85 Ppp2r1b Rhob Rhoc Nup98 Nup107 Dync1h1 Cdca8 Evl Dync1li1 Rangap1 Fmnl1 Ppp1cc LOC100909468 Aurkb Sec13 Xpo1 LOC100911204 Spc24 Spc25 Itgb3bp Sgol2 Rhod Ppp2r5e Incenp Nsl1 B9d2 Cdc20 Kif2a Kif2c Kif2b Bub1b Kif18a Ppp2r5c Ppp2r5a LOC100361457 Ppp2r5b Zwint Dsn1 Mad2l1 Casc5 Clasp2 Ercc6l Nuf2 Clasp1 LOC679582 Dvl1 Mkl1 Mapre1 Cdc42 Pmf1 Dvl2 Dvl3 Rhoa Pfn1 Pfn2 Ckap5 Scai Ska2 Sgol1 Zw10 Srf Ska1 CITRIC ACID CYCLE (TCA CYCLE)%REACTOME%R-RNO-71403.1 Citric acid cycle (TCA cycle) Idh3a Ogdh Mdh2 Idh3g Me2 Aco2 Fahd1 Idh2 Me3 Idh3B Cs Sdhc Sdhd Sdha Dlst Sucla2 Suclg2 Fh Sdhb Nnt Dld CHAPERONIN-MEDIATED PROTEIN FOLDING%REACTOME%R-RNO-390466.1 Chaperonin-mediated protein folding Cct6b Gnai3 Rgs9 Csnk2a2 Gnat3 Gnao1 Cct6a Csnk2a1 Tcp1 Cct7 Rgs7 Cct4 Gnat2 Pdcl Gnaz Cct3 Csnk2b Gnai2 Gnb3 Gnb5 Cct2 Gnb2 Gnb1 Gng13 Gng12 Gng11 Gnat1 Cct8 LOC100912034 Gnb4 Gng4 Gngt2 Gnai1 Gng5 Gngt1 Gng10 Gng8 Gng3 KINESINS%REACTOME%R-RNO-983189.1 Kinesins Kif21a Kif21b Kifc1 Kif3c Racgap1 Klc1 Kif22 Kif3b Kif23 Kif18b Kifap3 Kif11 Kif12 Kif4a Kif2a Kif6 Kif2c Kif1a Kif2b Kif1c Kif18a Kif27 Klc4 Kif9 Kif5b Kif13b Cenpe Kif5a Klc2 Klc3 Kif3a Kif20b Kif16b Kif26a Kif20a Kif26b Kif19 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL%REACTOME DATABASE ID RELEASE 66%10145904 Synthesis of IP3 and IP4 in the cytosol Plcd3 Plcb1 Plcz1 Plcd1 Pten Plcd4 Inpp5b Itpka Plce1 Pld4 Plcb3 Synj1 Plch1 Plch2 Plcb4 Inpp5d Plcg1 Itpkb Itpkc Itpk1 Ocrl Inpp5j CARGO RECOGNITION FOR CLATHRIN-MEDIATED ENDOCYTOSIS%REACTOME%R-RNO-8856825.1 Cargo recognition for clathrin-mediated endocytosis Agtr1b Agtr1a Syt11 Aak1 Sgip1 Eps15l1 LOC100909548 Itsn2 Scarb2 Igf2r Necap1 Egfr Agfg1 Snap91 Ubqln2 Picalm Tgoln2 Ldlr Tor1a Ston2 Syt1 Tfrc Vamp2 RGD1307443 Tf Chrm2 Necap2 Cd4 Tor1b Avp Dab2 Ston1 Ap2a2 Cops8 Cops2 LOC100361515 Cbl Vamp8 Stam2 Apob Sh3gl2 Sh3gl1 Sh3kbp1 Sh3gl3 Stam Nedd8 Itsn1 Wnt5a Cltc Cltb Clta Fzd4 Ap2s1 Cops4 Cops6 Ap2a1 Ap2m1 Cops3 Cops7b Cops7a Arrb1 Cd3g Slc2a8 Dvl2 Syt8 Arrb2 Cd3d Syt9 Syt2 Fcho2 Fcho1 M6pr Ldlrap1 Adrbk1 Vamp4 Vamp3 Adrb2 Vamp7 Grb2 Tacr1 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR%REACTOME DATABASE ID RELEASE 66%10145698 Activation of Ca-permeable Kainate Receptor Grik1 Dlg1 Grik3 Grik2 Ncald Grik5 Dlg3 Dlg4 SIGNALING BY RHO GTPASES%REACTOME DATABASE ID RELEASE 66%10144889 Signaling by Rho GTPases Cenpn Zwilch Cenpl Cenpo Klc1 Racgap1 Dync1li2 Cenpt Cenpu Abi1 Bub3 Bub1 Abi2 Potef Spdl1 Kntc1 Dync1i2 Mad1l1 Rtkn Myh9 Nck1 Cenpk Cenph Cenpi Rock2 Klc4 Cenpf Kdm1a Cenpe Cenpm Klc2 Ahctf1 Klc3 Ndel1 Rcc2 Noxo1 Arpc1b LOC100909750 Actb Inpp5b Pafah1b1 Rhpn1 Ncf1 Ncf4 Rhpn2 Ppp1r12a LOC100361515 Mis12 Dynll2 Ndc80 Cenpc Noxa1 Ppp1r14a Cenpa Dync1i1 Daam1 Srgap2 LOC100909840 Ptk2 Actg1 Cyfip2 Birc5 Nckap1 Taok1 Nup85 Cdh1 A2m Rhob Dlg4 Rhoc Nup98 Myh14 Myh11 Nup107 Prc1 Cit Cdca8 Flna Pkn1 Evl Cyfip1 Tax1bp3 Pkn2 Pkn3 Brk1 Cdc25c Rangap1 Fmnl1 Ppp1cb Baiap2 Ppp1cc LOC100909468 Aurkb Limk1 Gdi2 Sec13 Nf2 Xpo1 Pak2 Pak3 Pak1 Rac2 Wasl Nckap1l LOC100911204 Spc24 Spc25 Nox3 Nox1 Ocrl Abl1 Itgb3bp Arhgef6 Sgol2 Arhgef5 Rhod Arhgef39 Wasf1 Arhgef7 Arpc4 Rock1 Arhgef37 Ppp2r5e Arhgef38 Incenp Rhoq Arhgef33 Ktn1 Prex1 Arpc3 Nsl1 LOC102551071 Itsn1 B9d2 Arhgef2 Cdc20 Kif2a LOC102556447 Arhgef4 Kif2c Arhgef3 Kif2b Plekhg5 Men1 Arhgef19 Bub1b Arhgef18 Kif18a Plekhg2 Ppp2r5c Kalrn Ppp2r5a Nckipsd LOC100361457 LOC100912512 Ppp2r5b LOC687609 Zwint Dsn1 Vav2 Mylk Kif5b Gna13 Mad2l1 Vav1 Kif5a Arhgef11 Casc5 Akap13 Actr3 Arhgef16 Lin7b Arhgef15 Was Net1 Clasp2 Ect2 Ercc6l Arhgef26 Ctnna1 Fgd2 Mcf2l Nuf2 Tiam1 Pik3c3 Ncoa2 Tiam2 Clasp1 Vav3 LOC679582 Iqgap3 Dvl1 Mkl1 Fgd3 Pik3r4 Sos2 Pdpk1 Ngef Mapre1 Cdc42 LOC100911597 Pmf1 Dvl2 Dvl3 Pfn1 Pfn2 Ckap5 Scai Ska2 Wipf1 Wipf2 Wipf3 Iqgap1 Sgol1 Zw10 Srf Ska1 Arhgap18 Arhgap19 Arhgap21 Nup43 Arhgap17 Nup133 Myo9a Arhgap22 Arhgap10 Arhgap20 Srgap1 Srgap3 Arhgap39 Rhobtb2 Arhgap36 Depdc1b Rac1 Arhgap44 Arhgap35 Arhgap5 Arhgap6 Arhgdib Rhoj Ralbp1 Rhoh Nup37 Depdc7 Arhgap11a Dlc1 Syde1 Syde2 Fam13a Fam13b Gmip Arhgap15 Arhgap12 Arap1 Stard13 Tagap Chn2 Stard8 Ophn1 Arhgap1 Arhgap8 Rhot2 Rhot1 Diaph1 Ranbp2 Src Ppp2cb Ppp2ca Ywhah Ywhag Sfn Ppp2r1a Ywhaz Ywhab Ywhaq Ywhae Ppp2r1b Mapk1 Arhgap26 Arhgap25 Arhgap29 Arhgap23 Arhgap28 Arhgap27 Arhgap42 Arhgap40 Arhgap32 Arhgap30 Arhgap31 Hist1h2bo Dync1h1 Hist1h2bcl1 Hist2h3c2 Hist1h2bk H3f3b Dync1li1 Cybb Cyba Hmha1 LOC100910200 H2afx Hist1h4b LOC684841 Hist1h2bh Pik3r2 LOC100912290 Hist1h2ail1 Hist1h4m LOC102549173 LOC103690002 LOC100910152 LOC100912338 Hist1h3c H2afb3 Hist1h3f Hist2h4 LOC684819 Hist1h3a Myo9b H2afj Hist2h2aa3 Hist1h2bq Hist2h2aa2 LOC100364835 LOC684762 Actr2 Arhgap9 Rhoa Arhgdia Arpc5 Hist1h2bg LOC680097 Rhof Sos1 LOC684797 Rhog LOC100912418 Hist1h2ba Hist3h2bb Grb2 OLIGOMERIZATION OF CONNEXINS INTO CONNEXONS%REACTOME DATABASE ID RELEASE 66%10145304 Oligomerization of connexins into connexons Gjb1 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKK%REACTOME%R-RNO-442717.1 CREB phosphorylation through the activation of CaMKK Camkk1 Camk4 PEPTIDE CHAIN ELONGATION%REACTOME%R-RNO-156902.1 Peptide chain elongation Eef2 CLASS B 2 (SECRETIN FAMILY RECEPTORS)%REACTOME%R-RNO-373080.1 Class B 2 (Secretin family receptors) Ghrh Ramp3 Vipr2 Sct Gip Gipr Pth1r Iapp Crhr2 Gcgr Adgre1 Crhr1 Glp2r Pth2 Ramp2 Ghrhr Gng10 Pth Sctr Adm Crhbp Calcb Vip Calca Ramp1 Adcyap1r1 Ucn Adcyap1 Ucn2 Pth2r Adm2 Crh Gnb3 Gnb5 Gnb2 Gnb1 Gng13 Gng12 Gng11 LOC100912034 Gnb4 Glp1r Gcg Gng4 Gngt2 Gng5 Gngt1 Gng8 Gng3 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME DATABASE ID RELEASE 66%10145219 Activation of APC C and APC C:Cdc20 mediated degradation of mitotic proteins Psmc6 Psmb10 Psmb8 Psmb9 Psmb4 Psmb11 Bub3 Psmb5 Psmf1 Psmb6 Psmd4 Psmb2 Psmd5 Psmd8 Psmd9 Psmb3 Psma8 Psmd11 Psmd12 Anapc11 Ccna2 Ccna1 Anapc15 Psmd13 Anapc10 Psmd14 Psmc3 G6pc Ube2d1 Cdc20 Psmb7 Psmb1 Bub1b Mad2l1 Anapc7 Cdc26 Cdc27 Cdc23 Psma5 Pttg1 Ube2c Cdk1 Anapc16 Cdc16 Nek2l1 Anapc4 Psma2 Anapc2 Anapc1 Psmc5 Psmd2 Psma1 Psma4 Psmc1 Psma3 Psmc4 Psmc2 Psma6 Psme1 Nek2 Psmd1 Psme2 Psmd7 Psmd3 Psmd6 IRE1ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 66%10145532 IRE1alpha activates chaperones Sec63 Serp1 Sec61a1 Sec62 Sec61a2 Sec61b Asna1 LOC100363239 Sec61g Ern1 LOC100361694 RHESUS GLYCOPROTEINS MEDIATE AMMONIUM TRANSPORT.%REACTOME DATABASE ID RELEASE 66%10145662 Rhesus glycoproteins mediate ammonium transport. Rhag Rhcg RNA POLYMERASE I TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 66%10144885 RNA Polymerase I Transcription Termination Gtf2h1 Gtf2h2 Mnat1 RGD1565904 Ubtf Polr1b Taf1d Ercc3 Taf1c Polr2h Cd3eap Polr2e Znrd1 Polr2f Polr1c Polr2k Polr1a Ptrf Ercc2 Ttf1 LOC100912534 Cdk7 Twistnb Polr1e Ccnh Gtf2h3 Tbp Gtf2h5 Gtf2h4 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B%REACTOME%R-RNO-174048.1 APC C:Cdc20 mediated degradation of Cyclin B Anapc7 Cdc26 Cdc27 Cdc23 Ube2c Ube2d1 Cdk1 Anapc16 Cdc16 Cdc20 Anapc4 Anapc2 Anapc1 Anapc11 Anapc15 Anapc10 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME%REACTOME%R-RNO-975155.1 MyD88 dependent cascade initiated on endosome Map2k7 Ripk2 Map2k6 Ager Dusp3 Map2k4 Map3k8 Dusp4 Peli3 Nfkbib LOC100912399 Peli2 Map3k1 Traf6 Cul1 Vrk3 Rps6ka2 Rps6ka1 App Rps6ka3 Rps6ka5 Tlr9 LOC100912585 Tab1 Dusp7 Dusp6 Rela Atf1 Atf2 Map3k7 Peli1 Irak2 Nfkbia LOC100910771 Ube2n Jun Ppp2cb Ppp2ca Skp1 Ppp2r1a Nfkb2 Nfkb1 Mapk9 Tlr7 Mapk8 Tlr8 Fos S100b Irak4 Mapk7 Dhx9 Fbxw11 Chuk Ppp2r1b Ecsit Mapkapk3 Btrc Mapkapk2 Dhx36 Mapk1 Nkiras1 LOC100362142 Nod1 Nod2 Nkiras2 Creb1 Tab2 Tab3 LOC100912618 Ube2v1 Ikbkb Mapk14 Myd88 Tnip2 Mapk11 Mapk10 DSCAM INTERACTIONS%REACTOME%R-RNO-376172.1 DSCAM interactions Mapk8 Mapk13 Mapk12 Pak1 Dscaml1 Dscam Mapk14 Rac1 Mapk11 MISCELLANEOUS TRANSPORT AND BINDING EVENTS%REACTOME%R-RNO-5223345.1 Miscellaneous transport and binding events Nipal1 Tusc3 Mrs2 Nipal4 Pqlc2 Ankh Lrrc8e Lrrc8c Lrrc8b Lrrc8a Azgp1 Dmtn Magt1 Pip Add1 Nipa1 Add2 Ctns Nipa2 Add3 Nipal2 Nipal3 MITOCHONDRIAL TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 66%10145117 Mitochondrial transcription initiation Polrmt Tfam Tfb2m PINK PARKIN MEDIATED MITOPHAGY%REACTOME DATABASE ID RELEASE 66%10146045 Pink Parkin Mediated Mitophagy Vdac1 Mfn1 Mfn2 LOC100911485 Tomm6 Tomm70a Tomm7 Tomm40 Sqstm1 Atg12 Map1lc3a Pink1 Mterfd1 Tomm20 Tomm22 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R)%REACTOME%R-RNO-2404192.1 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) Cilp Pik3r1 Pik3r2 Fgf23 Fgf22 Fgf4 Fgf1 Fgf3 Tlr9 Fgf6 Fgf5 Fgf20 Gab1 Pde3b Igf2 Igf1 Fgf16 Pik3c3 Fgf17 Irs2 Fgf10 Fgf9 Fgfr2 Fgf7 Fgf2 Fgf8 Pik3r4 Fgfr3 Trib3 Pdpk1 Fgfr1 Fgfr4 Pik3cb Ptpn11 Fgf19 Them4 Irs1 Frs2 Sos1 Shc1 Akt2 Grb2 INTERCONVERSION OF POLYAMINES%REACTOME DATABASE ID RELEASE 66%10145061 Interconversion of polyamines Smox Sat1 RGD1564480 Paox NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%R-RNO-2122947.1 NOTCH1 Intracellular Domain Regulates Transcription Notch1 Maml1 Rbpj Crebbp Kat2a Snw1 Rbpjl2 ELECTRIC TRANSMISSION ACROSS GAP JUNCTIONS%REACTOME DATABASE ID RELEASE 66%10145507 Electric Transmission Across Gap Junctions Gja10 Panx1 Gjd2 Gjc1 THE NLRP3 INFLAMMASOME%REACTOME%R-RNO-844456.1 The NLRP3 inflammasome Panx1 Nlrp3 Hsp90ab1 Sugt1 Pycard Txn1 Txnip Mefv Pstpip1 P2rx7 FCGR ACTIVATION%REACTOME DATABASE ID RELEASE 66%10145910 FCGR activation Fcgr1a Cd247 Src Fgr Fyn Cd3g Fcgr2b Lyn LOC103693683 Yes1 Hck Fcgr2a Syk Fcgr3a SLIT2:ROBO1 INCREASES RHOA ACTIVITY%REACTOME DATABASE ID RELEASE 66%10146285 SLIT2:ROBO1 increases RHOA activity Rhoa Myo9b Robo1 Slit2 TICAM1-DEPENDENT ACTIVATION OF IRF3 IRF7%REACTOME DATABASE ID RELEASE 66%10145179 TICAM1-dependent activation of IRF3 IRF7 Irf3 COX REACTIONS%REACTOME DATABASE ID RELEASE 66%10145051 COX reactions Ptgs1 SIGNALING BY VEGF%REACTOME DATABASE ID RELEASE 66%10145273 Signaling by VEGF Abi1 Abi2 Rac1 Nos3 Nck1 Rock2 Rictor Cyfip1 Fyn Ncf1 Brk1 Ncf4 LOC103692716 Baiap2 Trib3 Cybb Cyba Pak2 Pak3 Pak1 Them4 Nckap1l Ptk2 Cyfip2 Nck2 Nckap1 Akt2 Prkcd Sh2d2a Hspb1 Wasf1 Flt4 Kras Src LOC100911280 Rock1 LOC100909609 Flt1 Ptk2b Pik3r1 Pxn Pik3r2 Figf Shc2 Vegfc Nrp1 Nrp2 Jup Akt1 Vegfb Axl Pgf Prkcb Vav2 Vav1 Prkcz Mtor Ctnna1 Mapk13 Mapk12 Kdr Dscam Vav3 Crk Bcar1 Mlst8 Mapkapk3 Pdpk1 Mapkap1 Mapkapk2 Cdc42 Prkaca Pik3cb Akt3 Vegfa Prkacb Rhoa Prkca Plcg1 Dock1 Hras Ctnnd1 Nras Cdh5 Mapk14 Elmo2 Rasa1 Shb Mapk11 REGULATION OF MECP2 EXPRESSION AND ACTIVITY%REACTOME%R-RNO-9022692.1 Regulation of MECP2 expression and activity Hdac1 Hipk2 Hdac2 Sin3a Hdac1l ACTIVATION OF TRKA RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145141 Activation of TRKA receptors Ntrk1 Ngf DOWNSTREAM SIGNALING OF ACTIVATED FGFR2%REACTOME DATABASE ID RELEASE 66%10145255 Downstream signaling of activated FGFR2 Kras Pik3r1 Frs3 Fgf23 Fgf22 Fgf4 Fgf1 Fgf3 Fgf6 Fgf5 Fgf20 Gab1 Fgf16 Fgf17 Fgf10 Fgf9 Fgfr2 Fgf7 Fgf2 Fgf8 Fgfr3 Fgfr1 Fgfr4 Ptpn11 Plcg1 Fgf19 Hras Nras Frs2 Sos1 Shc1 Grb2 VASOPRESSIN-LIKE RECEPTORS%REACTOME%R-RNO-388479.1 Vasopressin-like receptors Oxtr Oxt LOC100909648 Avpr1b Avpr1a Avp ANCHORING OF THE BASAL BODY TO THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 66%10146081 Anchoring of the basal body to the plasma membrane Dync1i2 Nphp1 Cep57 Cep97 Rab8a B9d1 Cep162 LOC691918 Haus3 Ninl Akap9 Nphp4 Ccp110 Tmem216 Dync1h1 Rpgrip1l Pafah1b1 LOC103692716 Rab3ip Mks1 Dctn1 C2cd3 Cntrl Dctn2 Cep76 Sept2 Pcm1 Cep78 LOC100912537 Ttbk2 Mark4 B9d2 LOC100911033 Cep164 Dctn3 Ofd1 Cep41 Sclt1 Tctn1 Sdccag8 Tubb5 Cep83 Prkar2b Cenpj Ywhag Cep89 Ppp2r1a Plk4 Ywhae Ahi1 LOC100912076 Tubg2 Haus2 Haus1 Haus5 Alms1 Haus4 Clasp1 Odf2 Tubb4a Cdk1 Iqcb1 Rab11a Nek2l1 Tmem67 Ssna1 Tubg1 Mapre1 Cep63 Prkaca Csnk1d Cep131 Tuba4a Cep250 Cep135 Csnk1e Ckap5 Cdk5rap2 Kif24 Pcnt Nek2 Cep72 Sfi1 Cep70 Actr1a LOC100911746 Nedd1 Fbf1 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION%REACTOME%R-RNO-2730905.1 Role of LAT2 NTAL LAB on calcium mobilization Pik3cb Pik3r1 Pik3r2 Lyn Sos1 Pdpk1 Shc1 Syk Grb2 Lat2 NEPHRIN FAMILY INTERACTIONS%REACTOME%R-RNO-373753.1 Nephrin family interactions Nck1 Fyn Kirrel Kirrel3 Kirrel2 Wasl Iqgap1 Nck2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX%REACTOME%R-RNO-937042.1 IRAK2 mediated activation of TAK1 complex LOC100910771 Tab2 Tab3 Tab1 Map3k7 Traf6 Irak2 PYRIMIDINE SALVAGE%REACTOME DATABASE ID RELEASE 66%10144845 Pyrimidine salvage Uckl1 Tk2 Cda Hdhd1 Uck2 Upp1 Upp2 Tk1 Uck1 Tymp Dck LOC100909857 TWIK-RELATED ALKALINE PH ACTIVATED K+ CHANNEL (TALK)%REACTOME DATABASE ID RELEASE 66%10145847 TWIK-related alkaline pH activated K+ channel (TALK) Kcnk16 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS)%REACTOME%R-RNO-456926.1 Thrombin signalling through proteinase activated receptors (PARs) Src Gnaq Gna11 Gna14 Gna15 Gna12 Gna13 Gnb3 Gnb5 Gnb2 Gnb1 Gng13 Gng12 Gng11 Mapk1 Arrb1 Arrb2 LOC100912034 Gnb4 F2rl3 F2r F2 Gng4 Gngt2 Gng5 Gngt1 Gng10 Gng8 F2rl2 Gng3 DEADENYLATION OF MRNA%REACTOME DATABASE ID RELEASE 66%10145638 Deadenylation of mRNA LOC100912571 Cnot6l Pabpc2 Cnot11 Pabpc6 Eif4a3 Tnks1bp1 Cnot8 Rqcd1 Pan2 Cnot3 Cnot1 Zcchc6 Cnot2 LOC100911431 Eif4a2 Pabpc1 Cnot7 Cnot4 Eif4a1 Eif4g1 LOC680559 Eif4b FORMYL PEPTIDE RECEPTORS BIND FORMYL PEPTIDES AND MANY OTHER LIGANDS%REACTOME DATABASE ID RELEASE 66%10145663 Formyl peptide receptors bind formyl peptides and many other ligands Hebp1 Fpr-rs6 Fpr-rs3 Fpr1 Fpr2 Fpr3 Anxa1 Fpr-rs4 ACTIVATION AND OLIGOMERIZATION OF BAK PROTEIN%REACTOME DATABASE ID RELEASE 66%10145015 Activation and oligomerization of BAK protein Bak1 Bid A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS%REACTOME%R-RNO-1971475.1 A tetrasaccharide linker sequence is required for GAG synthesis Gpc6 Bcan Agrn Vcan Ncan Xylt2 Gpc4 Gpc2 Dcn LOC100910284 B3gat1 B3gat3 B3gat2 LOC102550316 B4galt7 Cspg5 Cspg4 Sdc2 Gpc1 Sdc3 Sdc4 B3galt6 PKA ACTIVATION IN GLUCAGON SIGNALLING%REACTOME%R-RNO-164378.1 PKA activation in glucagon signalling Prkaca Prkacb Prkar2b Prkar2a Prkar1b Prkar1a CLASS C 3 (METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS)%REACTOME DATABASE ID RELEASE 66%10145488 Class C 3 (Metabotropic glutamate pheromone receptors) Tas2r144 Grm3 Casr Grm1 Grm6 Tas2r113 Grm2 Grm8 Tas2r114 Tas2r110 Gprc6a Tas2r124 Tas2r125 Tas2r126 Tas2r121 Tas2r103 Tas2r104 Tas2r123 Tas2r116 Tas2r140 Tas2r120 Tas2r102 Tas2r145 Tas2r119 Tas2r118 Tas2r117 Tas2r107 Tas2r108 Tas2r105 Tas2r106 Tas2r129 Tas2r109 Tas2r136 Tas2r137 Tas1r1 Tas2r135 Tas2r13 Tas2r130 Tas1r3 Tas2r139 Gabbr1 Gabbr2 CA-DEPENDENT EVENTS%REACTOME DATABASE ID RELEASE 66%10144989 Ca-dependent events Prkcd Pde1b Adcy8 Adcy9 Adcy5 Adcy4 Adcy7 Adcy6 Prkar1b Prkar1a Mapk1 Prkaca Prkacb Pla2g4a Adcy3 Prkar2b Prkca Prkar2a Camk4 Adrbk1 SUMOYLATION OF RNA BINDING PROTEINS%REACTOME DATABASE ID RELEASE 66%10146034 SUMOylation of RNA binding proteins Nup93 Nup43 Nup98 Nup133 Nup107 Aaas Nup155 Nop58 Nup210 Npap60 Nup35 Nup88 Nup37 Nupl2 Nupl1 Nup85 Nup153 Sumo1 Tpr Rae1 Nup54 Pom121 Nup205 Ube2i Ranbp2 Nup62 VITAMIN B5 (PANTOTHENATE) METABOLISM%REACTOME%R-RNO-199220.1 Vitamin B5 (pantothenate) metabolism Slc5a6 Pdzd11 Ppcdc Pank4 Coasy Pank3 Pank2 Ppcs Pank1 LOC100362038 Aasdhppt Vnn1 Fasn ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING%REACTOME%R-RNO-451326.1 Activation of kainate receptors upon glutamate binding Plcb1 Dlg1 Plcb3 Dlg3 Grik1 Grik3 Gnb3 Gnb5 Grik2 Ncald Grik5 Gnb2 Gnb1 Gng13 Gng12 Gng11 LOC100912034 Gnb4 Gng4 Gngt2 Gng5 Gngt1 Gng10 Dlg4 Gng8 Gng3 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS%REACTOME DATABASE ID RELEASE 66%10145878 Transcriptional activation of mitochondrial biogenesis Sirt4 Sirt3 Gabpb1 Acss2 Sod2 Idh2 DOWNSTREAM SIGNALING OF ACTIVATED FGFR1%REACTOME%R-RNO-5654687.1 Downstream signaling of activated FGFR1 Kras Pik3r1 Frs3 Fgf23 Fgf22 Fgf4 Fgf1 Fgf3 Fgf6 Fgf5 Flrt1 Flrt2 Fgf20 Gab1 Fgf16 Fgf17 Fgf10 Fgf9 Fgfr2 Fgf7 Fgf2 Fgf8 Fgfr3 Fgfr1 Fgfr4 Ptpn11 Plcg1 Fgf19 Hras Nras Frs2 Sos1 Shc1 Grb2 TRP CHANNELS%REACTOME%R-RNO-3295583.1 TRP channels Trpc4ap Trpv4 Trpv5 Trpv6 Mcoln2 Mcoln3 Trpm2 Trpv1 Trpc5 Trpm6 Trpm3 Trpm8 Trpm5 Trpc3 Trpc7 Trpm1 Trpc4 Mcoln1 Trpc6 Trpv3 Trpa1 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION%REACTOME%R-RNO-2173796.1 SMAD2 SMAD3:SMAD4 heterotrimer regulates transcription Smad3 Ccnt2 Smad2 Sp1 E2f5 Rbl1 Cdk9 Snw1 E2f4 Men1 Atp1b4 Ccnk Wwtr1 Tfdp1 Tfdp2 DARPP-32 EVENTS%REACTOME DATABASE ID RELEASE 66%10145005 DARPP-32 events Prkar1b Ppp1ca Pde4a Prkar1a Ppp2r1b Pde4d Pde4c Ppp1r1b Cdk5 Prkaca Prkacb Ppp2cb Prkar2b Ppp2ca Prkar2a Ppp2r1a ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON%REACTOME DATABASE ID RELEASE 66%10145137 Activation of IRF3 IRF7 mediated by TBK1 IKK epsilon Cd14 Tbk1 Ptpn11 Irf3 Tlr4 Ticam2 Ikbke Tank Traf3 GLUCAGON-TYPE LIGAND RECEPTORS%REACTOME%R-RNO-420092.1 Glucagon-type ligand receptors Sctr Vip Adcyap1r1 Adcyap1 Ghrh Vipr2 Sct Gip Gipr Gnb3 Gcgr Gnb5 Gnb2 Glp2r Gnb1 Gng13 Gng12 Ghrhr Gng11 LOC100912034 Gnb4 Glp1r Gcg Gng4 Gngt2 Gng5 Gngt1 Gng10 Gng8 Gng3 SUMO E3 LIGASES SUMOYLATE TARGET PROTEINS%REACTOME DATABASE ID RELEASE 66%10145992 SUMO E3 ligases SUMOylate target proteins Nr1h4 Nup43 Nup133 Trim27 Mdm2 Vhl Pias3 Aaas Pias1 Npap60 Stag1 Nup35 Nup37 Pias4 Pml Rad21 Pias2 Smc1a Stag2 Smc3 Sumo1 Sumo3 Pcna Brca1 Blm Mdc1 Zfp131 Pcgf2 Xpc Ube2i Hdac4 Uhrf2 Ranbp2 Foxl2 Satb2 Satb1 Birc5 Topors Thra Thrb Nsmce1 Ing2 Nsmce2 Mbd1 Nr1h3 Nr1h2 Top1 Safb Park7 Smc6 Tp53bp1 Smc5 Nr5a1 Rora Nr1i2 Rad52 Mitf Herc2 Hdac1 Xrcc4 LOC100911274 Nup88 Rpa1 Hipk2 Nup85 Phc1 Phc2 Nfkb2 Tfap2c Sin3a Rae1 Nup93 Nup98 Nup107 Rxra Nup210 Ppara Nupl2 Rela Nupl1 Tdg Cdca8 Scmh1 Nr5a2 Cbx4 Cbx2 Cbx8 Bmi1 Hdac2 Rnf2 Rangap1 Ring1 Ikbke Hdac1l Phc3 Aurkb Esr1 Nfkbia Nup205 Ddx5 Mta1 Nrip1 Pgr Ncoa1 Hist1h4b Incenp Dnmt1 LOC100912290 Nup155 Nop58 Hist1h4m Dnmt3b Hist2h4 Nup153 Parp1 Tpr Daxx Mkl1 Nup54 Pom121 LOC680097 Nup62 LOC100912418 AXON GUIDANCE%REACTOME%R-RNO-422475.1 Axon guidance LOC102552659 Erbb2 Egfr Kif4a Potef Cdk5 Csnk2a2 Dnm2 Nck1 Csnk2a1 Rock2 Arpc1b LOC100909750 Fyn Actb Ephb1 Ephb2 Ephb4 LOC100909840 Ephb3 Ptk2 Efnb2 Actg1 Efnb1 Efnb3 Myl12a Nck2 LOC100909609 Nrp1 Ranbp9 Pik3cd Kdr Tln1 Vegfa Prkca Lyn Dock1 Yes1 Gpc1 Rasa1 Rhob Shb Arhgef28 Rhoc Grin2b Grin1 Mmp9 Mmp2 Rps6ka5 LOC100912585 Pip5k1c Evl Ptprc Col9a1 Col9a2 Col9a3 Sdcbp Prkcq Col4a1 Cd72 Siah1 Ret Siah2 Dpysl2 Limk1 Dpysl5 Dpysl4 LOC100910964 Col4a2 Pak2 Sh3gl2 Fes Pak3 Nrcam Pak1 Gdnf Sh3kbp1 Reln Rnd1 Wasl Plxnd1 Dag1 Ntn1 Pdlim7 Ntn4 Map2k2 Pspn Abl1 Dpysl3 Crmp1 Rras Ank1 Arhgef7 Plxna2 Arpc4 Plxna1 Rock1 Gap43 Sema7a Rdx Arpc3 LOC103692570 Rap1gap Sema6d Itsn1 Cdk5r1 Epha10 Dcc Farp2 Sema5a L1cam Ezr Trem2 Spta1 Kalrn Gfra4 Sema4d LOC100361457 Plxnb1 Gfra3 LOC100912512 Gfra2 Dok4 Vav2 Dok1 Dok6 Dok5 Arhgef11 Sema3a Sema3e Actr3 Efna2 Efna1 Artn Efna4 Shc3 Nrtn Mapk13 Ptpra Mapk12 Dnm1 Tiam1 Dscaml1 Dab1 Vav3 Dscam Dnm3 Epha4 Ncam1 Sptbn1 Epha5 Lypla2 Msn Epha7 Ngef Epha8 Cdc42 Epha3 Epha2 Epha1 Pfn1 Pfn2 Itga2b Aph1b Psenen Aph1a LOC100911293 Psen2 Psen1 Ncstn Rac1 Arhgap35 Sdc2 Ap2a2 Src Pik3r3 Hsp90ab1 Cltc Clta Ap2s1 Ap2a1 Ap2m1 Mapk8 Vldlr Mapk7 Mapk1 Prkaca Prkacb Creb1 Mapk14 Mapk11 Sptan1 Gab1 Irs2 LOC103692716 Fgfr1 Grb10 Frs2 Kras Grb7 Dok2 Pik3r1 Pik3r2 Cxcl12 Nfasc Robo2 Robo3 Akap5 Enah Tyrobp Myo9b Vasp Abl2 Robo1 Cxcr4 Usp33 Slit3 Slit2 Csnk2b Actr2 LOC501189 St8sia4 Pik3cb Ptpn11 Rhoa Arpc5 Plcg1 Hras Nras Sos1 Shc1 Grb2 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE%REACTOME%R-RNO-416572.1 Sema4D induced cell migration and growth-cone collapse Rock1 Rhoa LOC102552659 Sema4d Plxnb1 Rock2 Erbb2 Rnd1 Arhgef11 Rhob Rhoc FREE FATTY ACIDS REGULATE INSULIN SECRETION%REACTOME DATABASE ID RELEASE 66%10145587 Free fatty acids regulate insulin secretion Plcb1 Plcb3 Ffar1 Gnaq Gna11 Gna14 Gna15 SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN%REACTOME DATABASE ID RELEASE 66%10145615 Synthesis, secretion, and deacylation of Ghrelin Igf1 Ache Gh1 Pcsk1 Mboat4 Ghrl Lep Ins1 Ins2 Sec11c Gcg MGC109340 Pla2g7 Spcs2 Bche Sec11a SIGNALING BY NOTCH3%REACTOME DATABASE ID RELEASE 66%10145952 Signaling by NOTCH3 Aph1b Psenen Ybx1 Aph1a Dll4 Egfr Jag1 LOC100911293 Notch3 Psen2 Psen1 Ncstn OXYGEN-DEPENDENT ASPARAGINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA%REACTOME DATABASE ID RELEASE 66%10145810 Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha Hif1an Epas1 Hif1a REPRODUCTION%REACTOME%R-RNO-1474165.1 Reproduction Prdm9 Kcnu1 Cd9 Catsper3 Catsper2 Izumo3 Izumo1 Catsper4 LOC100911976 Spam1 Acr Izumo4 Izumo2 Hyal5 Hvcn1 PHOSPHOLIPASE C-MEDIATED CASCADE: FGFR1%REACTOME%R-RNO-5654219.1 Phospholipase C-mediated cascade: FGFR1 Fgf17 Fgf10 Fgf9 Fgf2 Fgf8 Fgfr1 Fgf23 Fgf22 Fgf4 Fgf1 Fgf3 Fgf6 Plcg1 Fgf5 Fgf20 MELANIN BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 66%10146119 Melanin biosynthesis Oca2 Slc45a2 Tyrp1 Tyr LOC308670 DIGESTION AND ABSORPTION%REACTOME%R-RNO-8963743.1 Digestion and absorption Pir Slc2a5 Amy2a3 Pnliprp1 Chia RGD1309110 Pnliprp2 Alpp Npc1l1 Alpi Pnlip Amy1a Chit1 Guca2b Guca2a Lct Si Slc5a1 Chi3l3 Gucy2c Alppl2 Slc2a2 Lipf Clps GAP JUNCTION DEGRADATION%REACTOME DATABASE ID RELEASE 66%10145296 Gap junction degradation Cltb Clta Gja1 Dnm2 Dnm1 Myo6 Dab2 Ap2m1 Cltc O-LINKED GLYCOSYLATION OF MUCINS%REACTOME%R-RNO-913709.1 O-linked glycosylation of mucins Galnt9 LOC102550196 Gcnt1 A4gnt Muc13 C1galt1 Muc15 C1galt1c1 B3gnt4 Galnt16 B3gnt7 Galnt18 Galnt14 B3gnt2 Galnt15 B3gnt3 Galnt12 Galnt13 B3gntl1 Galnt10 St6galnac2 B3gnt6 St6gal1 Galntl5 Galnt6 Galnt5 B4galt6 St6galnac4 St3gal2 B3gnt8 St3gal3 Muc1 St6galnac3 B4galt5 B3gnt5 Chst4 St3gal1 Muc20 Galnt1 Galnt7 St3gal4 Galnt3 Galnt2 CTLA4 INHIBITORY SIGNALING%REACTOME DATABASE ID RELEASE 66%10145541 CTLA4 inhibitory signaling Cd80 Src Cd86 Fyn Ppp2r5e Ppp2r1b Akt1 LOC100909468 Akt3 Ptpn11 Ppp2r5c Ppp2cb Ppp2r5a Ppp2ca Ppp2r5b Ppp2r1a Lyn Yes1 Akt2 PENTOSE PHOSPHATE PATHWAY%REACTOME%R-RNO-71336.1 Pentose phosphate pathway Dera Rpe Shpk Tkt Rbks Prps1l1 Taldo1 Rpia Pgls Pgm2 Prps2 UBIQUINOL BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 66%10145949 Ubiquinol biosynthesis Pdss2 Coq2 PHASE I - FUNCTIONALIZATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 66%10144820 Phase I - Functionalization of compounds Smox Nr1h4 Cyp1b1 RGD1564480 Svs1 Doxl2 Doxl1 Cyp19a1 Fdx1l Por LOC100360055 Aoc3 Ces2c Cyp46a1 Maoa Cyp4f17 Aldh2 Paox Cyp4f18 Cyp4f39 Tbxas1 Cyp39a1 Pomc Hsp90ab1 Cyp2d5 Cyp51 Fdx1 LOC100361547 Cyp3a23/3a1 Cyp3a73 Cyp4f6 Cyp2u1 Cyp2c7 Cyp2e1 LOC100912391 Cyp2d4 Cyp3a18 Cyp24a1 Cyp1a1 LOC100910877 Ptgs1 Cyp2d2 Cyp1a2 Cyp2d3 Cyp2c6v1 Cyp4a2 Cyp4a1 Ptgis Rxra Cyp4a8 Cyp2j10 Cyp7b1 Cyp7a1 Ptges3 Cyp21a1 Fdxr Ptges3l1 Cyp2r1 Ncoa1 Cyp2b2 Cyp2c24 Cyp2s1 Cyp2b1 Marc2 Marc1 Aip Acss2 Cyp2b3 Ephx1 Nqo2 Cyp26c1 Aldh3a1 LOC100910040 Bphl Ahrr LOC100361492 Ahr Cyp11b2 Maob LOC100910127 Cyp27b1 Ces1d Cyp2c13 LOC100910481 Aadac Ncoa2 Cmbl Ces2 Ces2j Cyp2b21 Arnt Ces2e Ces2g Acss1 Cbr3 Cyp8b1 Ces2h LOC100911763 Aoc1 Cyp2b15 Fmo1 Cyp2b12 Adh4 Fmo2 Cyp2f4 Cyp26a1 Adh6 Cyb5r3 Arnt2 Adh7 Cyb5b Cyp4v3 Aldh1b1 Cyp26b1 LOC100365112 PRESYNAPTIC PHASE OF HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME DATABASE ID RELEASE 66%10146131 Presynaptic phase of homologous DNA pairing and strand exchange Rhno1 Rfc2 Bard1 Wrn Topbp1 Rbbp8 Rmi1 Rmi2 Rad51c LOC100911267 Hus1 Rad51d Rad51 Brca2 Rad50 Rpa1 Rpa2 Atm Atrip Rpa3 Brca1 Rad1 Atr Blm Rad17 Slc25a16 Rfc5 Xrcc2 Rfc4 Rad9a Nbn Rfc3 Rad9b Mre11a SLC-MEDIATED TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 66%10144952 SLC-mediated transmembrane transport Slc7a3 Slc7a2 Slc7a1 Slco4a1 Slc4a7 Slc4a9 Slc2a9 Slc11a2 Slc7a8 Slc7a9 Sri Fgf21 Slc50a1 Slc7a5 Slc7a6 Slc7a7 Slc6a2 Heph Slc14a1 Slc18a1 Slc7a10 Slc30a10 Slc4a4 Slc4a3 Slc22a15 Slc6a7 Slc4a8 Slc6a9 Slc2a12 Slc2a10 Slc6a6 Slc6a5 Slc12a4 Slc39a2 Slc12a2 Slc39a3 Slc12a1 Slc39a4 Slc39a6 Slc8b1 Slc38a3 Slc38a2 Slc38a5 Slc38a4 Slc22a6 Slc8a3 Slc12a5 Slc22a3 Slc3a1 LOC100911874 RGD1559971 Slc25a29 Slc43a2 Slc43a1 Slc22a7 Vegp2 Slc39a7 Slc22a1 Slc39a8 Slc22a2 Slc12a6 Slc12a7 Slc47a1 Slc8a2 Slc6a3 Slc8a1 RGD1304770 Slc35c1 Slc5a6 Pdzd11 Slc1a3 Bsg Slc1a5 Slc1a4 Slc15a1 Slc1a7 Slc1a6 Lcn1 Slc1a1 Slc5a4 Slc5a1 Slc5a2 Slc9a1 Slc2a2 Slc24a4 Slc24a2 Slc20a2 Slc10a6 Ahcyl2 Slc35d1 Slco3a1 Slc45a3 Slc2a6 Slc2a4 Lcn12 Slc5a10 Slc4a2 Slc4a5 Slc4a1 Slc7a11 Slc13a4 Slc41a1 Slc41a2 Slc40a1 Slc24a5 Slc13a1 Slc26a2 Slc13a2 Slc26a1 Slc13a3 Slco1c1 Lcn9 Slc5a9 Slc5a7 Slc20a1 Slc4a10 Slc15a3 Slc27a1 Slco1a1 Slc35b2 Rhag Slc44a4 Slco1a4 Slc35b3 Slco1a2 Slc44a5 Slc44a3 Rhcg Slco1b2 Slc25a10 Slc5a11 Slc2a13 Slc30a5 Slc16a10 Slc30a6 Slc30a8 Slc27a6 Slc39a14 Slc9a4 Slc9a5 Slco2b1 Slc31a1 Slc26a7 Slc26a9 Slc26a6 Slc30a1 Slc27a4 Slc26a3 Slc36a2 Slc33a1 Slc34a1 Slc35a2 Slc16a2 Slc34a3 Slc32a1 Slc38a1 Slc6a15 Slc6a14 Slc6a19 Slc6a18 Ctns Slc35b4 Slc36a4 Slc6a20 Slc36a1 Slco1a6 Slco2a1 Slc35d2 Apod Slc2a1 Slc9a2 Slc9a9 RGD1561777 Slc9a3 Slc9a6 Cp Slc9a8 Slc9a7 Slc6a11 Slc6a13 Slc6a1 Slc6a12 Slc16a3 Slc16a7 Slc16a8 Slc16a1 Slc22a5 Slc28a2 Slc28a1 Slc28a3 Slc29a3 Slc29a2 Slc29a4 LOC100911721 Slc29a1 LOC691960 Slco4c1 Slc21a4 Slc11a1 Avp Slc44a2 Runx1 Slc35a1 Slc5a8 Slc25a22 Slc17a5 Slc17a6 Slc17a7 Slc17a8 LOC100911440 Slc25a18 Slc5a5 Slc2a8 ASYMMETRIC LOCALIZATION OF PCP PROTEINS%REACTOME%R-RNO-4608870.1 Asymmetric localization of PCP proteins Psmc6 Psmb10 Psmb8 Psmb9 Psmb4 Psmb11 Psmb5 Psmf1 Psmb6 Psmd4 Psmb2 Psmd5 Psmd8 Psmd9 Psmb3 Psma8 Psmd11 Psmd12 Psmd13 Psmd14 Smurf1 LOC100361515 Psmc3 Pard6a G6pc Wnt5a Prickle1 Fzd1 Psmb7 Fzd3 Psmb1 Fzd2 Fzd4 Fzd7 Psma5 Psma2 Psmc5 Psmd2 Psma1 Dvl2 Psma4 Psmc1 Psma3 Psmc4 Psmc2 Psma6 Psme1 Psmd1 Psme2 Psmd7 Psmd3 Psmd6 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12%REACTOME%R-RNO-392170.1 ADP signalling through P2Y purinoceptor 12 Gnai3 Gnai2 Gnb3 Gnb5 Gnb2 Gnb1 Gng13 Gng12 Gng11 Gnat3 LOC100912034 Gnb4 Gng4 Gnai1 Gngt2 P2ry12 Gng5 Gngt1 Gng10 Gng8 Gng3 SIGNALING BY TGF-BETA FAMILY MEMBERS%REACTOME DATABASE ID RELEASE 66%10145195 Signaling by TGF-beta family members Furin Fstl1 Grem2 Fstl3 Amhr2 Smurf1 Cer1 Nog Foxh1 Tgfbr1 Ube2m E2f5 Cbl Hdac1l Snw1 Tgfbr2 Cgn Acvrl1 Bmp2 Amh Acvr2a Chrdl1 Smad9 Smad5 Smad6 Acvr1c Gdf2 Bmpr2 Tgfb1 Acvr1b Fst Zfyve16 Inhba Drap1 Smad3 Ccnt2 Smad2 Pard6a Nedd8 Fkbp1a Strap Usp9x Sp1 Ube2d1 Skil Rbl1 F11r Ncor2 Cdk9 Mtmr4 E2f4 Zfyve9 Men1 Hdac1 Tgif2 Arhgef18 Tgif1 Atp1b4 Trim33 Pmepa1 Ccnk Ube2d3 Pard3 Bambi Wwtr1 Tfdp1 Prkcz Tfdp2 Stub1 Parp1 Rhoa MITOTIC G2-G2 M PHASES%REACTOME DATABASE ID RELEASE 66%10145075 Mitotic G2-G2 M phases Psmc6 Psmb10 Psmb8 Psmb9 Psmb4 Psmb11 Psmb5 Psmf1 Psmb6 Mnat1 Psmd4 Rbx1 Psmb2 Dync1i2 Psmd5 Psmd8 Cep57 Psmd9 Psmb3 Rab8a Psma8 LOC691918 Psmd11 Psmd12 Haus3 Ccna2 Ccna1 Psmd13 Ninl Psmd14 Akap9 Ccp110 Cdk2 Pafah1b1 Ppp1r12a Psmc3 Ccnh Ajuba Hsp90ab1 Tubb5 Ppp2cb Ppp2ca Ywhag Skp1 Ppp2r1a Ywhae Fbxw11 Cdkn1a Ppp2r1b Nek2l1 Btrc Prkaca Nek2 Ppp2r3b Bora Fbxl18 Fkbpl Fbxl7 Ppme1 Foxm1 Cul1 Lcmt1 Tubgcp2 Aurka Dync1h1 Cdc25c LOC103692716 Ppp1cb Xpo1 Dctn1 Cntrl Dctn2 Cep76 G6pc Pcm1 Cep78 LOC100911033 Cep164 Dctn3 Ofd1 Cep41 Psmb7 Sdccag8 Psmb1 Prkar2b Cenpj Plk4 LOC100912076 Tubg2 Haus2 E2f1 Psma5 Haus1 E2f3 Haus5 Tpx2 Alms1 Cdk11b Clasp1 Haus4 Odf2 Cdk7 LOC100910954 Tubb4a Cdk1 Ssna1 Tubg1 Mapre1 Psma2 Cep63 Csnk1d Psmc5 Gtse1 Cep131 Psmd2 Psma1 Phlda1 Tuba4a Psma4 Cdc25b Cep250 Psmc1 Cdc25a Psma3 Cep135 Wee1 Csnk1e Psmc4 Pkmyt1 Cdk5rap2 Psma6 Psmc2 Ckap5 Ppp2r2a Psme1 Nme7 Tubgcp5 Pcnt Tubgcp6 Psme2 Psmd1 Cep72 Tubgcp3 Sfi1 Psmd7 Tubgcp4 Cep70 Optn Actr1a LOC100909844 Mzt1 Nedd1 Psmd3 Mzt2b Psmd6 SIGNALLING TO ERK5%REACTOME DATABASE ID RELEASE 66%10145365 Signalling to ERK5 LOC100912585 Mapk7 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS.%REACTOME%R-RNO-163200.1 Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. Ndufab1 Mt-nd4 Atp5f1 Ndufa7l Mt-nd5 Etfa Ndufaf7 Etfb Ndufa7 LOC683884 Ndufaf5 Mt-nd6 Nubpl Mt-nd2 LOC100911483 Ndufb10 Ndufb11 Ndufa12 Ndufa11 Mt-atp6 Ndufa13 Ndufa10 Ndufb6 Ndufb3 LOC100912599 Ndufb5 LOC100361505 Ndufc2 Ndufb9 Ndufb4 Ndufb8 Ndufb7 Ndufaf3 Atp5j2 Ndufaf1 Ndufa2 Ndufa5 Ndufaf4 Ndufa6 Mt-atp8 RGD1306782 Ndufa1 Ndufs3 LOC500350 Ndufs1 Ndufs4 Atp5g3 Ndufs5 Ndufs2 Ndufs8 Coq10a Ndufs6 Ndufs7 Timmdc1 Atp5g2 LOC684509 Acad9 Ndufb2 LOC679739 LOC100911417 Etfdh LOC679195 LOC100910710 LOC680288 Ucp2 Ecsit LOC688963 Ucp3 LOC100909612 Slc25a14 Atp5l Ucp1 Atp5o Atp5h Tmem126b Atp5i Atp5j LOC100363268 Ndufv3 LOC100361144 Ndufv1 Ndufv2 Atp5s Atp5e Atp5d Atp5b MYD88:MAL(TIRAP) CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME%R-RNO-166058.1 MyD88:MAL(TIRAP) cascade initiated on plasma membrane Map2k7 Ripk2 Map2k6 Ager Dusp3 Map2k4 Map3k8 Dusp4 Peli3 Nfkbib LOC100912399 Peli2 Map3k1 Traf6 Cul1 Vrk3 Rps6ka2 Rps6ka1 App Rps6ka3 Rps6ka5 Tirap LOC100912585 Tab1 Dusp7 Dusp6 Rela Atf1 Atf2 Map3k7 Peli1 Irak2 Nfkbia LOC100910771 Ube2n Jun Ppp2cb Ppp2ca Skp1 Ppp2r1a Nfkb2 Nfkb1 Mapk9 Mapk8 Fos S100b Mapk7 Dhx9 Fbxw11 Chuk Ppp2r1b Ecsit Mapkapk3 Btrc Mapkapk2 Mapk1 Nkiras1 LOC100362142 Nod1 Nod2 Nkiras2 Creb1 Tab2 Tab3 LOC100912618 Ube2v1 Ikbkb Mapk14 Myd88 Tnip2 Mapk11 Mapk10 FORMATION OF THE ACTIVE COFACTOR, UDP-GLUCURONATE%REACTOME DATABASE ID RELEASE 66%10144771 Formation of the active cofactor, UDP-glucuronate Ugdh Slc35d1 Ugp2 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK%REACTOME DATABASE ID RELEASE 66%10145366 Gastrin-CREB signalling pathway via PKC and MAPK Kras Mapk7 Egfr Hbegf Cckbr Mapk1 Gast Rps6ka2 Rps6ka1 Rps6ka3 Creb1 LOC100912585 Prkca Hras Nras Sos1 Grb2 INTRACELLULAR OXYGEN TRANSPORT%REACTOME%R-RNO-8981607.1 Intracellular oxygen transport Cygb Mb NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS%REACTOME DATABASE ID RELEASE 66%10145178 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Ripk2 Map2k6 Birc3 Birc2 Aim2 Cyld Hsp90ab1 Traf6 Panx1 Tab1 Sugt1 Casp4 Casp1 Casp2 Bcl2 Nlrp1a Txnip Mefv Map3k7 Pstpip1 Casp8 Irak2 Tnfaip3 P2rx7 Casp9 Nlrp3 Mapk13 Mapk12 Chuk Txn1 LOC100362142 Nod1 Nod2 LOC100910771 Tab2 Ube2n Tab3 LOC100912618 Pycard Ube2v1 Ikbkb Mapk14 Mapk11 VITAMINS B6 ACTIVATION TO PYRIDOXAL PHOSPHATE%REACTOME%R-RNO-964975.1 Vitamins B6 activation to pyridoxal phosphate Pdxk Aox1 Pnpo SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION%REACTOME DATABASE ID RELEASE 66%10145592 Sema4D mediated inhibition of cell attachment and migration Rras Rhoa Sema4d Plxnb1 Rnd1 Rac1 Arhgap35 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2%REACTOME%R-RNO-5140745.1 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 Cltb Ap2a2 Clta Fzd2 Ap2s1 Wnt5a Ap2a1 Ror1 Ror2 Ap2m1 Cltc RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME%R-RNO-110381.1 Resolution of AP sites via the single-nucleotide replacement pathway Xrcc1 Lig3 Apex1 Polb SCAVENGING BY CLASS B RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145958 Scavenging by Class B Receptors LOC685953 Scarb1 Cd36 Apob Apoa1 RGD1565355 REGULATION OF TLR BY ENDOGENOUS LIGAND%REACTOME DATABASE ID RELEASE 66%10146066 Regulation of TLR by endogenous ligand LOC685953 Cd14 Cd36 Apob Tlr4 Lbp RGD1565355 Tlr6 Tlr2 Tlr10 NOTCH-HLH TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 66%10145446 Notch-HLH transcription pathway Notch1 Notch2 Maml1 Notch4 Rbpj Crebbp Notch3 Kat2a Snw1 Rbpjl2 VITAMINS%REACTOME%R-RNO-211916.1 Vitamins Cyp27b1 Cyp2r1 Cyp24a1 Cyp26a1 Cyp26c1 Cyp26b1 UCH PROTEINASES%REACTOME DATABASE ID RELEASE 66%10146120 UCH proteinases Psmc6 Bard1 Psmb10 Psmb8 Psmb9 Psmb4 Psmb11 Psmb5 Yy1 Psmf1 Psmb6 Psmd4 Psmb2 Psmd5 Psmd8 Actr8 Psmd9 Psmb3 Psma8 Psmd11 Psmd12 Psmd13 Psmd14 Actl6a Mcrs1 Actb Ino80 Uchl3 Psmc3 Bap1 Senp8 RGD1561252 Asxl2 Ogt Foxk2 Uchl5 Ruvbl1 Adrm1 Uchl1 Nedd8 G6pc Psmb7 Psmb1 Ino80e Ino80d Nfrkb Psma5 Psma2 Psmc5 Psmd2 Psma1 Psma4 Psmc1 Psma3 Psmc4 Psmc2 Psma6 Psme1 Psmd1 Psme2 Psmd7 Ino80b Psmd3 Ino80c Psmd6 ADRENOCEPTORS%REACTOME%R-RNO-390696.1 Adrenoceptors Adra2a Adra1d Adra2c Adra2b Adra1a Adrb3 Adrb2 REGULATION OF TP53 EXPRESSION%REACTOME DATABASE ID RELEASE 66%10146179 Regulation of TP53 Expression LOC100910954 POST-TRANSLATIONAL PROTEIN MODIFICATION%REACTOME%R-RNO-597592.1 Post-translational protein modification Usp7 Ddb2 Pias3 Pias1 Yy1 Ddb1 Rbx1 Actr8 Stag1 Rad21 Smc1a Stag2 Smc3 Actl6a Mcrs1 Cops8 Cops2 Actb Sumo1 Sumo3 Ino80 Pcna Cul4b Cul4a Ube2v2 Xpc Ube2n Ube2i Ruvbl1 Hist1h2aa Ercc8 Rpa1 Cops4 Cops6 Cops3 Ripk2 Traf6 Cul1 Commd9 App Tab1 Rela Map3k7 Cd59 Ctsa Stam2 Plaur Nfkbia LOC100910771 Cst3 Muc20 Qsox1 Stam Rab4a Fcgr3a Ctsc C4a C4b Ctsz Mlec LOC100909666 LOC102549354 Psmb7 Psmb1 Ino80e Ino80d Nfrkb Psma5 Parp1 Rad23a Rad23b Cops7b Cops7a Psma2 Psmd2 Commd3 Bst1 Psmc2 Psmd1 Psmd7 Ino80b Psmd3 Ino80c Psmd6 Ccdc22 Fbxl19 Fbxl12 Fbxl13 Fbxl16 Fbxl15 Tgfa Prnd Eif5a Pex2 Derl1 Csf1 Ttll10 Clspn Rad18 Wfs1 Pex5 Ube2z Dcun1d5 Dcun1d4 Dcun1d3 Ube2t Ube2s Ttll9 LOC100909521 Ttll4 Ttll5 Ttll3 Ttll7 Ttll2 Nae1 Fbxl4 Fbxl5 F8 Scfd1 F7 F9 Ttll12 Fbxl8 Rbbp5 Skp1 Tnks Phc1 Phc2 Nfkb2 Fbxw11 Tfap2c Btrc Nod1 Nod2 Tnip2 Rxra Apol2 Prmt3 Hsp90b1 RGD1309808 Apol11a Apol3 LOC100910885 Apol9a Hist1h2bo Scmh1 Hist1h2bcl1 Cbx4 Hist1h2bk Cbx2 Cbx8 Bmi1 Hdac2 Rnf2 Usp13 Ring1 Phc3 Ogt Tnks2 Mta1 LOC100910717 LOC100910200 Hist1h4b Wdr5 Hist1h2bh Dnmt1 LOC100912290 Rbbp7 Hist1h4m LOC100912338 Dnmt3b Hist2h4 Hist2h2aa3 Hist1h2bq Hist2h2aa2 LOC100364835 Hist1h2bg LOC680097 LOC684797 LOC100912418 Hist1h2ba Mgat2 Mgat5 Mettl20 Mettl22 Sec24a Sec24b Copa Sec24d Mysm1 Asb18 Mgat3 Asb11 Asb12 Mgat1 Asb13 Asb14 Asb10 Keap1 Wdtc1 Fkbp8 Man1c1 Asb15 Asb17 Asb16 Adamts1 Man1a1 Adamts6 Adamts7 Uimc1 Adamts9 Sspo Cyr61 Cog4 Cog6 Cog8 Cog3 Ntng1 Ntng2 Cog1 Cog2 Chgb Igfbp1 Sec23ip Lman1l Igfbp5 Cog7 LOC102555167 Igfbp4 Alpl Kng1l1 Afp Cand1 Rab39a Mul1 Mfge8 Rab11b Ptp4a2 Cpm Thsd1 Ykt6 Sec24c Paf1 Igfbp7 Rfwd2 Notum Tmed7 Tmed3 LOC100911393 Tmed2 Eef2kmt Tex101 Aplp2 Rab6b Rab9a Napg Napb Napa Rtf1 Senp5 Mepe LOC100910849 Pigm Pigk Tmed9 Pigl Pigg LOC100911374 Pigh Nsf Dcaf11 Pigc Dcaf13 Pigb Piga Ankrd9 Dcaf10 Rab8b Pex14 Pex10 Pex13 Pex12 Fbxl22 Lrrc41 Usp47 Ube2c Usp48 Skp2 Fbxw10 Usp42 Chm Fbxw12 Ngly1 Fn3k Arcn1 Rab7b Becn1 Traf2 Pigw Pigv Pigy Pigx Rab33a Rab33b Pign Pigq Pigp Mxra8 Pigs Nucb1 Pigu Pigt Usp20 Usp26 Ggcx Usp21 Obsl1 Usp22 Rab2a Rab2b Trappc10 LOC100910410 Rab35 Rab34 Ly6g6c Rab36 Rabggta Usp19 Spon2 Spon1 Fn3krp Usp37 Il33 Ppp6c Manea Rab3c Rab3b Usp30 Vgf Neurl2 Trappc2l Rab43 Usp24 Usp25 Rab25 Stc2 Rab20 Rab21 Rab19 Prss41 Vdac1 Engase Rab23 Prss23 Prss21 Trappc6a Trappc6b Rab15 Rab12 Rab13 Ankrd28 Rabggtb Rab32 Rab30 Ly6g6d Usp14 Rab38 Usp18 Usp15 Rab1b Rab1a Usp11 Usp10 Tmem115 Ufd1l Sbspon Spaca4 Arfgap2 Dph1 Dcaf8 Atxn3 Dph3 Gpihbp1 Golgb1 Dph2 Klhl5 Arfgap3 Atxn7 Dcaf4 Sparcl1 Arfgap1 Dph5 Dph6 Ubxn1 Otoa LOC690251 LOC100910472 Penk Mcfd2 Preb Chst10 Kng1 Capzb Vdac2 Klhl2 Foxo4 Fbxo2 Eva1a Kng2 Fbxo9 Fbxo7 Cdh2 Rwdd3 Fbxo6 Fbxo4 Proz Cul9 Dcun1d2 Ube2k Plet1 Ube2h Ube2f Sec31a Ube2a Stx17 Pomt2 Pomgnt2 Dcaf7 Pomt1 Pros1 Klhl9 Dcaf5 Dcaf6 Dda1 Bglap Lrr1 Dhps Gosr2 Gosr1 Tmed10 Pomgnt1 Hrc Wdr20 Areg Stx5 Bet1 Arf5 Etfb Cnih1 Shisa5 Fuca2 Rnf123 Pofut2 Mfi2 Wdr48 Izumo1r Bre Cish Arf4 Bpifb2 Ctage5 Asgr1 Large Brcc3 Gyltl1b Rab27a Ccnf Psmd11 Gbf1 Psmd12 Ube2e3 Ccna2 Ctr9 Ccna1 Cnih3 Psmd13 Cnih2 Psmd14 Dtl Asgr2 Amtn Rab7l1 Wdr61 Commd7 Commd2 Cfp Commd1 Man2a1 Fut8 Serpind1 Man2a2 Rps2 Sprn Sema5b Tceb2 Mgat4b Tceb1 Commd4 Cul2 Commd5 Hif1a Mgat4a Commd6 Rnf152 Psmc3 Enam Fem1b Fem1a Serpinc1 Epas1 Ptrh2 Tada3 Hif3a Copz2 Copz1 Bcl10 Reck Lman2 Sec16a Sec16b Lman1 LOC102554393 Rnf181 Trappc2 Kctd7 Trappc5 Calu Bmp15 Rnf7 Kin Cd109 Rab27b Babam1 Fem1c Rab3a Josd2 Copb1 Josd1 Suds3 Opcml Eif5a2 Chst8 Rab7a Thy1 Tfg Tada2b Ly6e Ly6d Psca Ly6h Kbtbd8 Otulin Rab22a Rab4b Kbtbd7 Kbtbd6 Gpld1 Neu1 Trappc3 Kctd6 Mettl21a Arsi Pcsk9 LOC100910318 Arse Ube2q2 Hltf Arsg Ube2r2 Rab5b Kdelr1 Amelx Rab5c Rce1 Arsk Tbc1d20 Sts Capza2 Capza3 LOC100910143 Rab6a Commd10 Sumf2 Gan Sumf1 B3galnt2 Tecta Thsd7a Vnn3 Fam20c Usp3 Usp4 Usp5 Stambpl1 Kdelr2 Tmem132a LOC100911959 Thsd7b Lgals1 Rab9b Ppp6r3 Trappc1 Ppp6r1 Kdelr3 Tectb Art3 Fam20a Art4 Adamts13 Apc Otub1 Adamts15 Otud3 Ide Otud7b Hist2h2ab Adamts19 LOC100910557 Adamts16 Adamts17 Pomk Sptan1 Ambn Vcp Gas6 Adamts12 Rab18 Asb5 Asb6 Asb7 Msln Rab10 Klhl41 Rab14 Asb1 Asb3 Vnn1 Cdc34 Rab24 Zranb1 Asb8 Ripk1 Actr10 Rtn4rl2 Vcpip1 Ifih1 Tnip1 Klhl42 Gpaa1 Arsa RGD1565607 Otub2 LOC100911993 Tnfaip3 Rtn4rl1 Dync1h1 Tdg Lypd5 Nr5a2 Lypd8 Lypd1 Lypd6b Lypd2 Lypd3 Lypd4 LOC102553119 Dync1li1 LOC689730 Fbxo41 Bmyc Thbs2 Fbxo44 Polb Fbxo40 Wsb2 Copg1 Wsb1 Spsb3 Dctn5 Esr1 Dctn6 Spsb2 Adamtsl2 Spsb1 Gata3 Adamtsl3 Shprh Ddx5 Rnf20 Adamtsl4 Folr2 Nrip1 Rab3d Dctn4 Pgr Spsb4 Ncoa1 Folr1 Scg2 Btbd1 Btbd6 Fbxo22 Ube2g2 Ube2g1 Dohh Uso1 Scg3 Il6 Klhl13 Fbxo30 Gorasp1 Fbxo31 Klhl11 Fbxo32 Fbxo21 LOC100910107 Ddx58 St8sia1 Alg1 Klhl20 Gfpt2 Cntn4 Nus1 Cntn3 Alg2 Cntn5 Dolpp1 Pgap1 Gfpt1 Sae1 Rnf40 St8sia3 Alg6 Fam175b Alg3 Rcn1 Alg9 Zbtb16 Alg8 Klhl25 Klhl21 Uba1 Klhl22 Uba2 Renbp Fbxo10 Rab40c St3gal5 Mpi Usp2 Rab40b Pgm3 Icmt Pmm2 Fam175a Alg14 Fbxo15 Pmm1 Tulp4 Alg12 Fbxo11 Dnajc3 Daxx Sec22b Slc35a1 LOC100910954 Cope St8sia5 Cdk1 Sec23a St6galnac1 Mdm4 C3 Fbxw2 St6galnac2 Nudt14 Uba6 LOC501189 Taf10 Gp2 St8sia4 LOC100910177 Sec22a Senp2 Dolk St6gal1 Fbxw9 Uba3 St6gal2 Nub1 Amdhd2 Senp1 Rhoa Fbxw5 St6galnac4 Eef2 Fbxw4 St6galnac3 Nagk Fbxw8 Gne Fbxw7 Mpdu1 Man1a2 Dpagt1 LOC103690024 Xpnpep2 St6galnac6 Gnpnat1 LOC100912059 Dpm3 Ckap4 Serpina10 Dpm2 LOC100363782 Dpm1 Usp17l5 Uap1 Taf9b Trim27 Mdm2 Vhl Socs5 Socs3 Leo1 Vwa1 Stambp Commd8 Socs6 Pias4 Pml Pias2 Brca1 Blm Mdc1 Zfp131 Pcgf2 Hdac4 Uhrf2 Foxl2 Satb2 Satb1 Topors Usp8 Thra Thrb Fuom Nsmce1 Smad3 Slc35c1 Ing2 Nsmce2 Smad2 Mbd1 Nedd8 Nr1h3 Nr1h2 Top1 Usp9x Safb Park7 Ube2d1 Smc6 Tp53bp1 Fuk Smc5 Nr5a1 Tsta3 Rora Gmds LOC100911225 Nr1i2 Rad52 Fpgt Mitf Hdac1 Herc2 Xrcc4 LOC100911274 Timp1 Ube2d3 Edem3 Calr Man1b1 Rnf139 Ganab Edem2 Uggt1 Dmp1 Trim13 Rnf5 Prkcsh B3gnt6 Galntl5 Galnt6 Galnt5 B3gnt8 Muc1 B3gnt5 Chst4 Galnt1 Galnt7 Ceacam10 Galnt3 Galnt2 Canx Lamc1 Rnf103 March6 Fbn1 Ceacam1 Ikbke Fgg Traf3 Siah2 Thbs1 Sar1b Apob Apoe Fga Apoa2 Lamb1 Dag1 Lamb2 Spp1 Ank1 Nop58 Adamts4 Adamts3 Adamts5 Sema5a Spta1 Fn1 P4hb Adamts14 Nans Sptbn1 Npl Dhdds Cmas Ltbp1 Nanp Bard1 Pten Lhb Rab8a Ccp110 Furin Alpp Alpi Mvd Bmp4 Col7a1 F2 Cga Neu4 Neu2 Neu3 Srd5a3 Sin3a Rraga Galnt9 LOC102550196 Gcnt1 A4gnt Muc13 C1galt1 Muc15 C1galt1c1 Galnt16 Galnt18 Galnt14 Galnt15 Galnt12 Galnt13 B3gntl1 Galnt10 Tgfbr1 Ube2m Hdac1l Dctn1 Cdc73 Dctn2 Dctn3 Os9 Usp33 Slc17a5 Rab11a Arrb1 Csnk1d Arrb2 Actr1a Sel1l Nr1h4 Mbtps1 Dync1li2 Kat2a Dync1i2 Dynll2 Tomm70a Dync1i1 Tomm20 Birc5 Apoa1 Nup88 Hipk2 B3gnt4 B3gnt7 B3gnt1 Alppl2 B3gnt2 B3gnt3 Nup85 Nlrp3 Rae1 Glb1 Pnpla2 St3gal2 St3gal3 St3gal1 St3gal4 St3gal6 Nup93 Nup98 Nup107 Nup210 LOC100911750 Ppara Nupl2 Nupl1 Cdca8 Rangap1 B4galt1 Aurkb B4galt3 Sec13 B4galt2 B4galt6 B4galt4 B4galt5 Nup205 Incenp G6pc Ktn1 Nup155 Cdc20 Men1 LOC100911615 Nup153 Vcan Tpr Arsb Mkl1 Nup54 Pom121 Nup62 Cp Psmc6 Psmb10 Nup43 Nup133 Psmb8 Psmb9 Psmb4 Psmb11 Aaas Psmb5 Psmf1 Psmb6 Psmd4 Psmb2 Psmd5 Psmd8 Npap60 Psmd9 Psmb3 Nup35 Psma8 Nup37 Sdc2 Rhot1 Uchl3 Bap1 Senp8 RGD1561252 Asxl2 Foxk2 Uchl5 Ranbp2 Adrm1 Mat2b Uchl1 Fbxl18 Fbxl7 Tgoln2 Fgf23 Tf Fstl1 Fstl3 Chrdl1 Ins1 Ins2 Birc3 Birc2 Cyld Psmc5 Psma1 Psma4 Psmc1 Cdc25a Psma3 Psmc4 Psma6 Psme1 Psme2 LOC100909844 Adrb2 FGFR1B LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 66%10145285 FGFR1b ligand binding and activation Fgf22 Fgf1 Fgf3 Fgf10 Fgf2 Fgfr1 HOMOLOGY DIRECTED REPAIR%REACTOME DATABASE ID RELEASE 66%10144914 Homology Directed Repair Rfc1 Rhno1 Rfc2 Bard1 Wrn Topbp1 Rbbp8 Rmi1 Pole2 Rmi2 Rad51c Pole4 Polh LOC100911267 Spidr Rad51d Eme2 Rad51 Brca2 Eme1 Polq Rtel1 Rad50 Ppp4r2 Ppp4c Ccna2 Ccna1 Atm Atrip LOC100909750 Cdk2 Rpa3 Lig3 Pole Pcna Xrcc3 Brca1 Rad1 Blm Atr Slx4 Mus81 Slx1b Rad17 Palb2 Sirt6 Gen1 Rfc5 Xrcc2 Rfc4 Rad9a Nbn Rfc3 Abl1 Rad9b Mre11a Hus1 Rad52 Rpa1 Rpa2 Ercc1 Xrcc1 Parp2 Parp1 Pold2 Pold1 Pold4 Slc25a16 Fen1 TRANSCRIPTION-COUPLED NUCLEOTIDE EXCISION REPAIR (TC-NER)%REACTOME%R-RNO-6781827.1 Transcription-Coupled Nucleotide Excision Repair (TC-NER) Rfc1 Rfc2 Gtf2h1 Gtf2h2 Usp7 Pole2 Pole4 Ppie Ddb1 Mnat1 Rbx1 RGD1565904 Isy1 Polr2g Polr2h Polr2e Polr2f Polr2j Polr2k Polr2d Polr2i Polr2b Polr2c Polr2a Xab2 Cops8 LOC100912534 Cops2 Rpa3 Lig3 Zfp830 Pole Prpf19 Tcea1 Pcna Cul4b Uvssa Ccnh Cul4a Hmgn1 Xpa Gtf2h3 Rfc5 Rfc4 Rfc3 Gtf2h5 Gtf2h4 Ercc5 Ercc8 Ercc3 Ercc6 Rpa1 Rpa2 LOC100911295 LOC100911822 Cops4 Aqr Cops6 Ercc2 Ercc1 Lig1 Cops3 Xrcc1 LOC100911727 Cdk7 Cops7b Cops7a Pold2 Pold1 Pold4 TRANSCRIPTIONAL REGULATION BY RUNX2%REACTOME DATABASE ID RELEASE 66%10146258 Transcriptional regulation by RUNX2 Psmc6 Psmb10 Psmb8 Psmb9 Psmb4 Psmb5 Psmf1 Psmb6 Psmd4 Rbx1 Cul1 Psmb2 Psmd5 Psmd8 Psmd9 Psmb3 Psmd11 Psmd12 Psmd13 Psmd14 Psmc3 Cbfb Ppm1d Rbm14 LOC100911677 Sox9 G6pc Cdk4 Psmb7 Psmb1 Ccnd1 Skp1 Stub1 Psma5 Runx2 Skp2 Cdk1 Psma2 Psmc5 Psmd2 Psma1 Psma4 Psmc1 Psma3 Psmc4 Psmc2 Psma6 Psme1 Psmd1 Psme2 Psmd7 Psmd3 Psmd6 PRE-NOTCH PROCESSING IN GOLGI%REACTOME%R-RNO-1912420.1 Pre-NOTCH Processing in Golgi Notch1 Tmed2 Notch2 Notch4 Notch3 Furin CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA%REACTOME DATABASE ID RELEASE 66%10145175 Cytosolic sensors of pathogen-associated DNA Nlrp4 Dtx4 Tbk1 Ager Ddx41 Nlrp4a Irf3 Trim21 Trim32 Nfkbib App Rela Nfkb2 Nfkb1 S100b Dhx9 Stat6 Chuk Dhx36 Nkiras1 Nfkbia Nkiras2 Tmem173 Ikbkb Crebbp Myd88 Mre11a HDL ASSEMBLY%REACTOME DATABASE ID RELEASE 66%10145449 HDL assembly Prkaca Prkacb Bmp1 Abca1 A2m Apoa1 Zdhhc8 ERYTHROCYTES TAKE UP OXYGEN AND RELEASE CARBON DIOXIDE%REACTOME DATABASE ID RELEASE 66%10145820 Erythrocytes take up oxygen and release carbon dioxide Rhag Hbb-b1 Hba1 Car2 Aqp1 Slc4a1 Car1 LOC287167 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN%REACTOME%R-RNO-1234174.1 Regulation of Hypoxia-inducible Factor (HIF) by oxygen Psmc6 Psmb10 Hif1an Psmb8 Vhl Psmb9 Psmb4 Psmb11 Psmb5 Psmf1 Psmb6 Psmd4 Psmb2 Rbx1 Psmd5 Psmd8 Psmd9 Psmb3 Psma8 Psmd11 Psmd12 Psmd13 Psmd14 Egln2 Tceb2 Tceb1 Cul2 Cited2 Hif1a Limd1 Psmc3 Epas1 Hif3a Egln3 Ajuba Crebbp G6pc Ube2d1 Psmb7 Psmb1 Ube2d3 Psma5 Arnt Psma2 Psmc5 Psmd2 Psma1 Psma4 Psmc1 Psma3 Psmc4 Psmc2 Psma6 Psme1 Psmd1 Psme2 Psmd7 Psmd3 Psmd6 PHASE 2 - PLATEAU PHASE%REACTOME%R-RNO-5576893.1 Phase 2 - plateau phase Cacna1c Cacng7 Cacna1d Cacng1 Kcne1 Kcne2 Cacng5 Kcne4 Kcne3 Cacnb4 Cacng8 Cacnb1 Cacnb2 Kcnq1 Cacna2d3 Cacna1f Kcne5 Cacna1s Cacng2 Cacng3 Cacna2d2 Cacna2d4 Cacng4 Akap9 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER%REACTOME%R-RNO-6782210.1 Gap-filling DNA repair synthesis and ligation in TC-NER Rfc1 Rfc2 Gtf2h1 Gtf2h2 Usp7 Pole2 Pole4 Ppie Ddb1 Mnat1 Rbx1 RGD1565904 Isy1 Polr2g Polr2h Polr2e Polr2f Polr2j Polr2k Polr2d Polr2i Polr2b Polr2c Polr2a Xab2 LOC100912534 Rpa3 Lig3 Zfp830 Pole Prpf19 Tcea1 Pcna Cul4b Uvssa Ccnh Cul4a Hmgn1 Gtf2h3 Rfc5 Rfc4 Rfc3 Gtf2h5 Gtf2h4 Ercc8 Ercc3 Ercc6 Rpa1 Rpa2 LOC100911295 LOC100911822 Aqr Ercc2 Lig1 Xrcc1 LOC100911727 Cdk7 Pold2 Pold1 Pold4 RHO GTPASE CYCLE%REACTOME DATABASE ID RELEASE 66%10145340 Rho GTPase cycle Arhgap18 Arhgap19 Arhgap21 Arhgap17 Racgap1 Myo9a Arhgap22 Arhgap10 Arhgap20 Srgap1 Srgap3 Arhgap39 Rhobtb2 Arhgap36 Rac1 Depdc1b Arhgap44 Arhgap35 Arhgap5 Arhgap6 Arhgdib Rhoj Ralbp1 Rhoh Depdc7 Arhgap11a Dlc1 Syde1 Syde2 Fam13a Fam13b Gmip Arhgap15 Arhgap12 Arap1 Inpp5b Stard13 Tagap Chn2 Stard8 Ophn1 Arhgap1 Arhgap8 Rhot2 Rhot1 Srgap2 A2m Arhgap26 Arhgap25 Arhgap29 Arhgap23 Arhgap28 Arhgap27 Arhgap42 Arhgap40 Arhgap32 Rhob Arhgap30 Rhoc Arhgap31 Gdi2 Hmha1 Rac2 Ocrl Arhgef6 Rhod Arhgef5 Arhgef39 Arhgef7 Arhgef37 Arhgef38 Rhoq Arhgef33 Pik3r2 Prex1 Itsn1 Arhgef2 LOC102556447 Arhgef4 Arhgef3 Plekhg5 Arhgef19 Arhgef18 Plekhg2 Kalrn LOC100912512 LOC687609 Myo9b Vav2 Gna13 Vav1 Arhgef11 Akap13 Arhgef16 Arhgef15 Net1 Ect2 Arhgef26 Fgd2 Mcf2l Tiam1 Tiam2 Vav3 Arhgap9 Fgd3 Sos2 Ngef Cdc42 Rhoa Arhgdia Rhof Rhog Sos1 GLUTATHIONE CONJUGATION%REACTOME%R-RNO-156590.1 Glutathione conjugation Gstp1 Gsto1 Gstm7 Ggct Esd Gclm Gstm5 Gsto2 Gstk1 Cndp2 Gclc LOC100912430 Gstt2 Ggt7 Ggt6 Chac2 Chac1 Mgst3 Oplah Gstz1 Gsta5 Gss Akr1a1 Hpgds Gstm4 Mgst1 PTK6 DOWN-REGULATION%REACTOME DATABASE ID RELEASE 66%10146208 PTK6 Down-Regulation Srms Ptpn1 Ptk6 TP53 REGULATES TRANSCRIPTION OF SEVERAL ADDITIONAL CELL DEATH GENES WHOSE SPECIFIC ROLES IN P53-DEPENDENT APOPTOSIS REMAIN UNCERTAIN%REACTOME DATABASE ID RELEASE 66%10146175 TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain Rabggtb Chm Rabggta CYCLIN A B1 B2 ASSOCIATED EVENTS DURING G2 M TRANSITION%REACTOME%R-RNO-69273.1 Cyclin A B1 B2 associated events during G2 M transition Cdk2 Ppp2r3b Cdc25c Cdk7 Ppp2r1b Cdk1 Ppme1 Mnat1 Foxm1 Lcmt1 Ccnh Cdc25b Xpo1 Cdc25a Wee1 Ppp2cb Ppp2ca Pkmyt1 Ppp2r2a Ppp2r1a Ccna2 Ccna1 SPHINGOLIPID METABOLISM%REACTOME%R-RNO-428157.1 Sphingolipid metabolism Psap Sgpl1 Kdsr Fa2h Ppap2a Arsa Ppap2b Sgpp2 Sptssb Ctsa Sptssa Aldh3b1 LOC498300 Cers4 Cers3 Cers6 RGD1564463 Csnk1g2 Osbp Hexb Hexa Asah1 Cers1 Acer2 Acer1 Acer3 Cers2 Vapa Neu4 Degs2 Neu2 Gdf1 Gltp Sptlc3 Sptlc1 B4galnt1 Prkd3 Neu3 Sptlc2 Cerk Enpp7 Prkd1 Gba Neu1 Prkd2 Galc Asah2 Arsi Sgms1 Vapb Smpd1 Arse Ormdl1 Cptp Arsg Smpd2 Esyt3 Gla Smpd3 Arsk Glb1l Sts Aldh3a2 Esyt2 Sphk2 Arsb Smpd4 Gba2 Col4a3bp Ormdl2 Sumf2 Sumf1 B3galnt1 Ppap2c Ugt8 Glb1 Ugcg Samd8 Gm2a Degs1 SPERM:OOCYTE MEMBRANE BINDING%REACTOME DATABASE ID RELEASE 66%10145840 Sperm:Oocyte Membrane Binding Izumo3 Izumo1 LOC100911976 Izumo4 Izumo2 Cd9 CRISTAE FORMATION%REACTOME%R-RNO-8949613.1 Cristae formation LOC100911417 Atp5f1 LOC500350 Atp5g3 Atp5l Atp5g2 Atp5o Atp5h Mt-atp6 Atp5i Atp5j Atp5j2 Atp5s Atp5e Atp5d Mt-atp8 Atp5b AROMATIC AMINES CAN BE N-HYDROXYLATED OR N-DEALKYLATED BY CYP1A2%REACTOME%R-RNO-211957.1 Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 Cyp1a2 ABACAVIR TRANSPORT AND METABOLISM%REACTOME DATABASE ID RELEASE 66%10145942 Abacavir transport and metabolism Nt5c2 Adal Adh6 Slc22a1 Slc22a2 Slc22a3 REGULATION OF CYTOSKELETAL REMODELING AND CELL SPREADING BY IPP COMPLEX COMPONENTS%REACTOME DATABASE ID RELEASE 66%10145641 Regulation of cytoskeletal remodeling and cell spreading by IPP complex components Arhgef6 Rsu1 Actn1 Parvb Lims1 PHOSPHOLIPASE C-MEDIATED CASCADE; FGFR3%REACTOME DATABASE ID RELEASE 66%10146099 Phospholipase C-mediated cascade; FGFR3 Fgf23 Fgf4 Fgf1 Fgf16 Fgf17 Plcg1 Fgf5 Fgf9 Fgf2 Fgf8 Fgfr3 Fgf20 RAF MAP KINASE CASCADE%REACTOME%R-RNO-5673001.1 RAF MAP kinase cascade Ereg Nrg1 Btc LOC102552659 Erbb3 Erbb2 Nrg3 Egfr Hbegf Nrg4 Fyn Ptk2 Nrg2 Shc2 Ranbp9 Pdgfa Pdgfb Tln1 Vwf Apbb1ip Rasa1 Dlg4 Grin2d Camk2g Grin2b Grin1 Nefl Rasgrf1 Dusp4 Dlg1 Dlg2 Frs3 Dlg3 Camk2d Actn2 Camk2a Dusp7 Dusp6 Fgb Ret Fgg LOC100909468 Hgf Fga Gdnf Map2k2 Pspn Ppp2r5e Il2rg G6pc Pdgfra Pdgfrb Psmb7 Psmb1 Ppp2r5c Spta1 Lrrc7 Ppp2r5a Gfra4 Gfra3 Ppp2r5b Gfra2 Pbp2 Fn1 Artn Dusp9 Dusp2 Shc3 Dusp5 Nrtn Rasal3 Psma5 Ptpra Csk Rasal1 Rasal2 Rasgrp1 Rap1a Pebp1 Ncam1 Rasgrp4 Sptbn1 Rasgrp3 Pea15 Dusp1 Mark3 Psma2 Araf Rasa4 Psmd2 Il5 Spred1 Spred2 Rasgef1a Il2 Psmc2 Rasa2 Rasa3 Itga2b Il2ra Csf2 Psmd1 Psmd7 Il3ra Nf1 Iqgap1 Kit Syngap1 Psmd3 Kitlg Psmd6 Il2rb Dusp16 Psmc6 Map3k11 Csf2ra Psmb10 Csf2rb Ksr1 Rapgef2 Psmb8 Wdr83 Psmb9 Ksr2 Raf1 Psmb4 Ppp5c Psmb11 Psmb5 Il17rd Psmf1 Il5ra Psmb6 Cnksr1 Psmd4 Cnksr2 Psmb2 Dusp10 Psmd5 Paqr3 Psmd8 Psmd9 Psmb3 Psma8 Psmd11 Psmd12 Psmd13 Psmd14 Fgf2 Psmc3 Src Ppp2cb Ppp2ca Ppp2r1a Ywhab Ppp2r1b Mapk1 Jak3 Jak1 Vcl Sptan1 Fgf23 Fgf22 Fgf4 Fgf1 Fgf3 Fgf6 Fgf5 Lamtor3 Fgf20 Fgf16 Lamtor2 Fgf17 Irs2 Fgf10 Fgf9 Fgfr2 Fgf7 Fgf8 Fgfr3 Fgfr1 Fgfr4 Fgf19 Erbb4 Irs1 Frs2 Kras Psmc5 Arrb1 Psma1 Tek Psma4 Psmc1 Arrb2 Psma3 Psmc4 Psma6 Lat Psme1 Angpt1 Hras Psme2 Nras Sos1 Shc1 Grb2 ABASIC SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 66%10144981 Abasic sugar-phosphate removal via the single-nucleotide replacement pathway Apex1 Polb CRMPS IN SEMA3A SIGNALING%REACTOME%R-RNO-399956.1 CRMPs in Sema3A signaling Crmp1 Plxna2 Plxna1 Fyn LOC103692570 Nrp1 Cdk5r1 Cdk5 Dpysl2 Dpysl5 Dpysl4 LOC100910964 Fes Sema3a Dpysl3 REGULATION OF TP53 ACTIVITY THROUGH ACETYLATION%REACTOME DATABASE ID RELEASE 66%10146001 Regulation of TP53 Activity through Acetylation Ing2 Map2k6 Rbbp7 Akt1 Hdac1 LOC364561 Pin1 Brpf3 Brd7 Brpf1 Brd1 Pml Kat6a Ing5 Hdac2 Mbd3 LOC100910954 Chd3 Hdac1l Chd4 Akt3 Mta2 Gatad2a Tmem55b Pip4k2b Pip4k2c Akt2 Meaf6 Gatad2b BIOSYNTHESIS OF MARESINS%REACTOME%R-RNO-9018682.1 Biosynthesis of maresins LOC100361547 Cyp3a23/3a1 Cyp3a73 Cyp2d5 Cyp2c7 Cyp2e1 Cyp2d4 Cyp3a18 Alox5 LOC100910877 Cyp2d2 Ephx2 Cyp1a2 Cyp2d3 Cyp2c6v1 TP53 REGULATES TRANSCRIPTION OF CELL CYCLE GENES%REACTOME%R-RNO-6791312.1 TP53 Regulates Transcription of Cell Cycle Genes Tnks1bp1 Cnot8 Rqcd1 Cnot3 Cenpj Cnot1 Sfn Cnot2 Ccna2 Plk2 Ccna1 Ccne2 Aurka Plk3 Cnot7 Ccne1 Cnot4 Cdk2 E2f7 E2f8 Btg2 Cdc25c Cdkn1a Cdkn1b Cnot6l Cdk1 Cnot11 Pcna Gadd45a Bax PLC BETA MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 66%10144985 PLC beta mediated events Prkcd Plcb1 Gnai3 Plcb3 Gnat3 Pla2g4a Gnao1 Adcy3 Prkar2b Prkar2a Gnat2 Gnaz Pde1b Adcy8 Adcy9 Adcy5 Adcy4 Gnai2 Adcy7 Adcy6 Prkar1b Prkar1a Plcb4 Mapk1 Prkaca Prkacb Gnat1 Prkca Camk4 Adrbk1 Gnai1 REGULATION OF EXPRESSION OF SLITS AND ROBOS%REACTOME DATABASE ID RELEASE 66%10146286 Regulation of expression of SLITs and ROBOs Dag1 Robo1 Usp33 Slit2 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION%REACTOME DATABASE ID RELEASE 66%10145475 GABA synthesis, release, reuptake and degradation Slc6a11 Dnajc5 Slc6a13 Slc6a1 Gad2 Slc6a12 Rab3a Gad1 Abat Aldh5a1 Rims1 Stx1a Cplx1 Syt1 Vamp2 Stxbp1 Slc32a1 INTEGRIN ALPHAIIB BETA3 SIGNALING%REACTOME DATABASE ID RELEASE 66%10145476 Integrin alphaIIb beta3 signaling Fn1 Src Csk Tln1 Crk Rasgrp1 Rasgrp2 Rap1a Vwf Apbb1ip Ptpn1 Bcar1 Fgb Fgg Pdpk1 Akt1 Rapgef4 Fga Itga2b Ptk2 Sos1 Shc1 Syk Grb2 FCERI MEDIATED MAPK ACTIVATION%REACTOME DATABASE ID RELEASE 66%10145166 FCERI mediated MAPK activation Map2k7 Kras Map2k4 LOC100912399 Map3k1 Rac1 Jun Vav2 Vav1 Mapk9 Mapk8 Fos Vav3 Mapk1 Pak2 Pak1 Lat Plcg1 Lyn Hras Nras Sos1 Lcp2 Syk Shc1 Grb2 Mapk10 PTK6 ACTIVATES STAT3%REACTOME DATABASE ID RELEASE 66%10146200 PTK6 Activates STAT3 Socs3 Stat3 Stap2 Ptk6 CLEC7A INFLAMMASOME PATHWAY%REACTOME%R-RNO-5660668.1 CLEC7A inflammasome pathway Il1b Pycard Casp8 SIGNALING BY NTRK1 (TRKA)%REACTOME%R-RNO-187037.1 Signaling by NTRK1 (TRKA) Dusp3 Dusp4 Vrk3 Rps6ka2 Rps6ka1 Rps6ka3 Rps6ka5 LOC100912585 Dusp7 Dusp6 Atf1 Ap2a2 Irs2 Dnal4 Ralgds Kidins220 Sh3gl2 Irs1 Frs2 Kras Pik3r1 Pik3r2 Shc2 Cltc Clta Ntrk1 Ngf Ppp2cb Ppp2ca Ppp2r1a Ap2s1 Ap2a1 Ap2m1 Shc3 Mapk7 Crk Rap1a Ppp2r1b Mapkapk3 Mapkapk2 Mapk1 Pik3cb Rhoa Creb1 Crkl Hras Nras Sos1 Mapk14 Rapgef1 Mapk11 Shc1 LOC100911248 Grb2 PEPTIDE HORMONE METABOLISM%REACTOME%R-RNO-2980736.1 Peptide hormone metabolism Gh1 Ffar1 Pcsk1 Mboat4 Ghrl Lhb Igf1 Gip Ins1 Ins2 Tshb Bche Inhba Cga Slc30a5 Slc30a6 Slc30a8 Ache Pomc Ctsz Gnat3 Ctsd Gzmf Ace3 Dpp4 Lep Cpa3 Ctsg Grp Gpr119 Npepo Ffar4 Ero1l Gzmn Ero1lb Inha Exoc3 Inhbc Cma1 LOC100910060 Mme Exoc2 Exoc1 Exoc6 Exoc5 Exoc8 Exoc7 Cpb2 Cpb1 Ren Fshb Agt Ace LOC691670 Gnb3 Gng13 Atp6ap2 Sec11c Gcg MGC109340 Pla2g7 Spcs2 Sec11a CELL CYCLE%REACTOME DATABASE ID RELEASE 66%10144722 Cell Cycle Rfc1 Rfc2 Mdm2 Pole2 Kif23 Pole4 Mnat1 Rbx1 LOC100910252 Stag1 Pds5b Pias4 Pds5a Cdca5 Rad21 Smc1a Stag2 Smc3 Esco2 Esco1 Sumo1 Rpa3 Pole Pcna Brca1 Ccnh Blm Mdc1 Ube2v2 Ube2n Ruvbl1 Rfc5 Rfc4 Rfc3 Ube2d1 Tp53bp1 Rbl1 Cdk4 Akt1 E2f4 Hdac1 Herc2 Rpa1 Ccnd1 Rpa2 RGD1310212 Tfdp1 Tfdp2 Lig1 Kif20a Slc25a16 Fen1 Prkca Lyn Cul1 Ptk6 Ensa Arpp19 Psmb7 Psmb1 Dsn1 Psma5 LOC100911727 Cdk7 Pold2 Psma2 Pold1 Pold4 Psmd2 Psmc2 Psmd1 Psmd7 Psmd3 Psmd6 Rhno1 Bard1 Wrn Topbp1 Rbbp8 Rmi1 Rmi2 Rad50 Cep57 Rab8a LOC691918 Haus3 Prim2 Pola2 Ccne2 Ninl Ccne1 Prim1 Akap9 Ccp110 Mcm2 Atrip Mcm4 Mcm3 Cdk2 Mcm5 Clspn Mcm6 Mcm10 Rad1 Atr Mcm8 Mcm7 Rad17 Orc4 Orc5 Orc6 Orc1 Orc2 Setd8 Orc3 Cdc7 Rad9a Nbn Cdc6 Rad9b Cdc45 Mre11a Hus1 Ppp2cb Ppp2ca Skp1 Ppp2r1a Fbxw11 Ppp2r1b Btrc Mapk1 Akt3 Tinf2 Hist1h2bo Cnep1r1 Hist1h2bcl1 Rbl2 Hist2h3c2 Gorasp2 Hist1h2bk H3f3b Cks1l E2f5 Hdac1l Cables1 Numa1 Dyrk1a Lemd2 Cdkn2b Zfp385a Terf2ip Cenpw Nek6 Smarca5 Blzf1 Cdkn2c Hdac8 Cdk6 Cks1b Nek7 LOC100909949 Dctn1 Gmnn LOC100910200 Ccnd3 Whsc1 Cntrl Mcph1 H2afx Prdm9 Hist1h4b Dctn2 RGD1563307 Cep76 Mis18bp1 LOC684841 Rnf8 Hist1h2bh Acd Pcm1 Cep78 Rb1 LOC100912290 Ncapg Rbbp7 E2f2 Pot1b Hist1h2ail1 LOC686349 Hist1h4m LOC100911033 Lemd3 LOC102549173 Cep164 Mau2 LOC103690002 Dctn3 Tert Ofd1 Cep41 LOC100910152 Lmna Pot1 Vrk2 LOC100912338 Ncaph2 Hist1h3c Sdccag8 H2afb3 Lin37 Hist1h3f Vrk1 Ctdnep1 Prkar2b Lin52 Cenpj Hist2h4 Hjurp LOC684819 Lin54 Hist1h3a Plk4 Smc4 H2afj Hist2h2aa3 Tmpo Hist1h2bq Espl1 Hist2h2aa2 Smc2 Gins3 Gins4 LOC100364835 Gins1 LOC684762 Gins2 LOC100912076 Tubg2 Haus2 Haus1 Haus5 Alms1 Haus4 Terf1 Odf2 Terf2 Tubb4a Cdt1 Lmnb1 Lin9 Ncapg2 Ssna1 Tubg1 Cep63 Csnk1d Cep131 Tuba4a Cep250 Cep135 Csnk1e Cdk5rap2 Pcnt Hist1h2bg Cep72 LOC680097 Sfi1 Cep70 LOC684797 LOC100912418 Actr1a Hist1h2ba Nedd1 Hist3h2bb Cenpn Zwilch Cenpl Cenpo Dync1li2 Cenpt Cenpu Bub3 Bub1 Spdl1 Kntc1 Dync1i2 Mad1l1 Csnk2a2 Cenpk Cenph Cenpi Csnk2a1 Cenpf Cenpe Uimc1 Cenpm Ahctf1 Ndel1 Rcc2 LOC100909750 Pafah1b1 Ppp1r12a Mis12 LOC102555167 Dynll2 Ndc80 Cenpc Cenpa Dync1i1 Birc5 Rfwd2 Taok1 Nup88 Nup85 Anapc7 Cdc26 Cdc14a Cdc27 Cdc23 Pttg1 Ube2c Skp2 Cdkn1a Cdkn1b Anapc16 Cdc16 Nek2l1 Rae1 Anapc4 Anapc2 Anapc1 Lpin2 Lpin3 Lpin1 Nek2 Nup93 Nup98 Rab2a Nup107 Nup210 Anapc11 Nupl2 Anapc15 Aurka Anapc10 Nupl1 Fzr1 Fbxo5 Cdca8 Cdc25c Rangap1 Ppp1cb Ppp1cc LOC100909468 Aurkb Sec13 Xpo1 Rab1b Nup205 Rab1a LOC100911204 Spc24 Spc25 Abl1 Itgb3bp Sgol2 Ppp2r5e Incenp G6pc Nup155 Nsl1 B9d2 Cdc20 Kif2a Kif2c Kif2b Bub1b Kif18a Ppp2r5c Ppp2r5a Ppp2r5b Zwint Mad2l1 Casc5 Nup153 Clasp2 Ercc6l Nuf2 Tpr Clasp1 LOC679582 Mapre1 Cdc42 Pmf1 Nup54 Ckap5 Pom121 Ska2 Nup62 Sgol1 Zw10 Ska1 Psmc6 Nup43 Psmb10 Nup133 Psmb8 Psmb9 Psmb4 Aaas Psmb11 Psmb5 Psmf1 Psmb6 Bre Psmd4 Psmb2 Psmd5 Psmd8 Npap60 Psmd9 Psmb3 Nup35 Psma8 Brcc3 Nup37 Psmd11 Psmd12 Ccna2 Ccna1 Psmd13 Psmd14 Phf20 Atm Psmc3 Ajuba Ranbp2 Src Hsp90ab1 Babam1 Tubb5 Ywhah Ywhag Prkcb Sfn Ywhaz Ywhab Ywhaq Ywhae Prkaca Ppp2r3b Bora Fbxl18 Fkbpl Fbxl7 Ppme1 Foxm1 Lcmt1 Tubgcp2 Dync1h1 Dync1li1 LOC103692716 Akt2 Gorasp1 Csnk2b Fam175a E2f1 E2f3 Tpx2 Cdk11b LOC100910954 Cdk1 Mdm4 Chek2 Gtse1 Psmc5 Psma1 Phlda1 Psma4 Cdc25b Cdc25a Psmc1 Psma3 Wee1 Pkmyt1 Psmc4 Psma6 Ppp2r2a Psme1 Nme7 Tubgcp5 Psme2 Tubgcp6 Tubgcp3 Tubgcp4 Optn LOC100909844 LOC100363782 Mzt1 Mzt2b TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G1 CELL CYCLE ARREST%REACTOME%R-RNO-6804116.1 TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest Cdk2 E2f7 E2f8 Ccna2 Cdkn1a Ccna1 Cdkn1b Ccne2 Ccne1 INTERLEUKIN-2 SIGNALING%REACTOME%R-RNO-9020558.1 Interleukin-2 signaling Stat5a Jak3 Il2rg Il2 Ptk2b Jak1 Il2ra Shc1 Syk Il2rb DEPURINATION%REACTOME DATABASE ID RELEASE 66%10144975 Depurination Mpg Ogg1 Mutyh G2 M DNA REPLICATION CHECKPOINT%REACTOME%R-RNO-69478.1 G2 M DNA replication checkpoint Wee1 Pkmyt1 Cdk1 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX%REACTOME DATABASE ID RELEASE 66%10145392 Formation of the beta-catenin:TCF transactivating complex Leo1 Hist1h2bo Hist1h2bcl1 Hist2h3c2 Hist1h2bk H3f3b Smarca4 Hdac1l Tle3 Crebbp Rbbp5 Cdc73 LOC100910200 H2afx Hist1h4b LOC684841 Hist1h2bh LOC100912290 Hist1h2ail1 Hist1h4m LOC102549173 Tert LOC103690002 LOC100910152 Men1 LOC100912338 Hdac1 Hist1h3c H2afb3 Hist1h3f Hist2h4 LOC684819 Hist1h3a H2afj Hist2h2aa3 Hist1h2bq Hist2h2aa2 Ash2l LOC100364835 LOC684762 Pygo2 Tcf7 Hist1h2bg Lef1 LOC680097 Tcf7l1 Bcl9l LOC684797 LOC100912418 Tle4 Hist1h2ba Tle1 Hist3h2bb Tle2 Pygo1 ACTIVATION OF THE TFAP2 (AP-2) FAMILY OF TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 66%10146233 Activation of the TFAP2 (AP-2) family of transcription factors Cited1 Cited4 Yeats4 Tfap2b Tfap2c Crebbp Cited2 Tfap2a Tfap2d Tfap2e ATF6 (ATF6-ALPHA) ACTIVATES CHAPERONES%REACTOME%R-RNO-381033.1 ATF6 (ATF6-alpha) activates chaperones Mbtps1 Mbtps2 Atf6 SHC-MEDIATED CASCADE:FGFR2%REACTOME%R-RNO-5654699.1 SHC-mediated cascade:FGFR2 Kras Fgf16 Fgf17 Fgf10 Fgf9 Fgfr2 Fgf7 Fgf2 Fgf8 Fgf23 Fgf22 Fgf4 Fgf1 Fgf3 Fgf6 Fgf5 Hras Nras Sos1 Shc1 Fgf20 Grb2 G1 PHASE%REACTOME%R-RNO-69236.1 G1 Phase Ccnd3 Src Ppp2r3b Rb1 E2f2 Rbl1 Cdk4 Mnat1 Cul1 Ptk6 E2f4 Ppp2cb Ppp2ca Ccnd1 Skp1 Ppp2r1a Tfdp1 Tfdp2 Rbl2 LOC100909750 E2f1 E2f3 Cks1l Skp2 Cdkn1a Cdk7 Cdkn1b Ppp2r1b E2f5 Ccnh Cdkn2b Ppp2r2a Lyn Cdkn2c Cdk6 Cks1b Abl1 SYNTHESIS OF CL%REACTOME DATABASE ID RELEASE 66%10145873 Synthesis of CL Crls1 SIGNALING BY PDGF%REACTOME DATABASE ID RELEASE 66%10145268 Signaling by PDGF Stat5a Src Kras Grb7 Stat1 Pdgfra Pik3r1 Pdgfrb Pik3r2 Stat3 Nck1 Pdgfa Pdgfb Furin Col9a1 Col9a2 Stat6 Col9a3 Crk Col4a1 Bcar1 Thbs2 Pik3cb Thbs1 Ptpn11 Pdgfc Col4a2 Pdgfd Plg Thbs4 Plat Plcg1 Hras Crkl Nras Sos1 Rasa1 Ptpn12 Rapgef1 Nck2 Spp1 Grb2 LOC100911248 SIGNALING BY FGFR%REACTOME DATABASE ID RELEASE 66%10145253 Signaling by FGFR Frs3 RGD1565904 Fgf23 Fgf22 Polr2g Fgf4 Polr2h Fgf1 Polr2e Fgf3 Polr2f Fgf6 Polr2j Fgf5 Polr2k Polr2d Polr2i Polr2b Polr2c Polr2a Fgf20 Gab1 Mknk1 LOC100912534 Esrp2 Gtf2f1 Esrp1 Gtf2f2 Fgf16 Rbfox2 Fgf17 Fgfrl1 Tia1 Fgf10 Tial1 Fgfbp3 Fgf9 Fgfbp1 Fgfr2 Fgf7 Fgf2 Spry2 Fgf8 Cbl Fgfr3 Fgfr1 Fgfr4 Fgf19 Frs2 Kras Src Pik3r1 Hnrnph1 Ppp2cb Ppp2ca Ppp2r1a LOC100911822 Flrt1 Flrt2 Ncbp2 Ncbp1 Mapk1 Spred1 Ptpn11 Spred2 Plcg1 Hras Nras Hnrnpm Hnrnpf Sos1 Shc1 Galnt3 Grb2 FRS-MEDIATED FGFR3 SIGNALING%REACTOME%R-RNO-5654706.1 FRS-mediated FGFR3 signaling Kras Frs3 Fgf23 Fgf22 Fgf4 Fgf1 Fgf3 Fgf6 Fgf5 Fgf20 Fgf16 Fgf17 Fgf10 Fgf9 Fgfr2 Fgf7 Fgf2 Fgf8 Fgfr3 Fgfr1 Fgfr4 Ptpn11 Fgf19 Hras Nras Sos1 Frs2 Grb2 ACTIVATION OF DNA FRAGMENTATION FACTOR%REACTOME DATABASE ID RELEASE 66%10145439 Activation of DNA fragmentation factor Dffa Kpna1 Kpnb1 LOC100911856 Casp3 Hmgb2 RGD1559962 CASPASE ACTIVATION VIA EXTRINSIC APOPTOTIC SIGNALLING PATHWAY%REACTOME%R-RNO-5357769.1 Caspase activation via extrinsic apoptotic signalling pathway Faslg Appl1 Cflar Fadd Dcc Traf2 Casp3 Ripk1 Tradd Tnfsf10 Casp8 Casp9 Fas INTERLEUKIN-21 SIGNALING%REACTOME%R-RNO-9020958.1 Interleukin-21 signaling Stat5a Jak3 Il21r Il2rg Stat1 Il21 Jak1 Stat3 BETA-CATENIN INDEPENDENT WNT SIGNALING%REACTOME DATABASE ID RELEASE 66%10145579 Beta-catenin independent WNT signaling Plcb1 Psmc6 Psmb10 Psmb8 Psmb9 Psmb4 Psmb11 Pde6b Nlk Plcb3 Psmb5 Psmf1 Psmb6 Pde6a Psmd4 Rac1 Psmb2 Psmd5 Psmd8 Psmd9 Psmb3 Psma8 Psmd11 Psmd12 Psmd13 Psmd14 Ap2a2 LOC100361515 Psmc3 Daam1 Pde6g Pard6a Wnt5b Wnt5a Prickle1 Fzd1 Cltc Cltb Fzd3 Clta Fzd2 Gnao1 Fzd4 Fzd7 Fzd6 Prkcb Ap2s1 Ppp3r1 Wnt1 Wnt11 Wnt4 Gnat2 Ap2a1 Ror1 Ror2 Ap2m1 Gnb3 Gnb5 Gnb2 Gnb1 Gng13 Gng12 Gng11 Prkca LOC100912034 Gnb4 Gng4 Gngt2 Gng5 Gngt1 Gng8 Gng3 Camk2a Map3k7 Smurf1 LOC100910771 Rac2 Gng10 G6pc Psmb7 Psmb1 Psma5 Dvl1 Psma2 RGD1560225 Psmc5 Psma1 Psmd2 Ppp3ca Psma4 Dvl2 Psmc1 Dvl3 Arrb2 Rhoa Psma3 Pfn1 Psmc4 Psma6 Psmc2 Psme1 Psmd1 Lef1 Psme2 Psmd7 Psmd3 Psmd6 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS%REACTOME%R-RNO-73817.1 Purine ribonucleoside monophosphate biosynthesis Impdh1 Impdh2 Pfas Ppat LOC100912917 Adss Gmps Lhpp Atic Gart Adsl Adssl1 Paics GRB7 EVENTS IN ERBB2 SIGNALING%REACTOME%R-RNO-1306955.1 GRB7 events in ERBB2 signaling Nrg1 Grb7 LOC102552659 Erbb3 Erbb2 Nrg2 DEFENSINS%REACTOME%R-RNO-1461973.1 Defensins Defb26 Defb28 Ccr6 Defb30 Defb18 Defb36 RatNP-3b Defb14 Defb12 Defb29 Defb49 Defb25 Tlr10 Defb43 Defb44 Cd4 Art1 Defb13 Defb41 Defb1 Defb22 Defb23 Defb20 Defb21 Np4 Defa7 Defa11 Defa5 Defa10 Tlr2 RUNX2 REGULATES BONE DEVELOPMENT%REACTOME DATABASE ID RELEASE 66%10146257 RUNX2 regulates bone development Runx2 Rbm14 LOC100911677 PROPIONYL-COA CATABOLISM%REACTOME DATABASE ID RELEASE 66%10144800 Propionyl-CoA catabolism Pccb Mcee Mmaa Mut KANDUTSCH-RUSSELL PATHWAY%REACTOME DATABASE ID RELEASE 66%10146182 Kandutsch-Russell pathway Ebp Dhcr7 Sc5d Dhcr24 COMPLEMENT CASCADE%REACTOME%R-RNO-166658.1 Complement cascade C1s Elane C1r Masp2 C1qb Colec10 C4a C1qa C4b LOC100909666 Gzmm LOC102549354 C2 Vtn C5ar1 Cd59 Cpn1 Cpn2 Cr2 Cpb2 Clu C5ar2 Cd46 Cfd Serping1 Colec11 C6 Cfhr1 Cd19 C8g C3 RGD1564614 Cd81 C8a C8b Cfh F2 C3ar1 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 66%10145155 MyD88 cascade initiated on plasma membrane Map2k7 Ripk2 Map2k6 Ager Dusp3 Map2k4 Map3k8 Dusp4 Peli3 Nfkbib LOC100912399 Peli2 Map3k1 Traf6 Cul1 Vrk3 Rps6ka2 Rps6ka1 App Rps6ka3 Rps6ka5 LOC100912585 Tab1 Dusp7 Dusp6 Rela Atf1 Atf2 Map3k7 Peli1 Irak2 Nfkbia LOC100910771 Ube2n Jun Ppp2cb Ppp2ca Skp1 Ppp2r1a Nfkb2 Nfkb1 Mapk9 Mapk8 Fos S100b Mapk7 Dhx9 Fbxw11 Chuk Ppp2r1b Ecsit Mapkapk3 Btrc Mapkapk2 Mapk1 Nkiras1 LOC100362142 Nod1 Nod2 Nkiras2 Creb1 Tab2 Tab3 LOC100912618 Ube2v1 Ikbkb Mapk14 Myd88 Tnip2 Mapk11 Mapk10 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS%REACTOME%R-RNO-141405.1 Inhibition of the proteolytic activity of APC C required for the onset of anaphase by mitotic spindle checkpoint components Anapc7 Cdc26 Cdc27 Cdc23 Ube2c Bub3 Ube2d1 Anapc16 Cdc16 Cdc20 Anapc4 Anapc2 Anapc1 Bub1b Anapc11 Anapc15 Mad2l1 Anapc10 INTESTINAL HEXOSE ABSORPTION%REACTOME%R-RNO-8981373.1 Intestinal hexose absorption Slc2a5 Slc2a2 Slc5a1 DOPAMINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME%R-RNO-212676.1 Dopamine Neurotransmitter Release Cycle Rab3a Rims1 Lin7c Cplx1 Stx1a Lin7a Syn3 Syt1 Syn2 Vamp2 Stxbp1 Ppfia1 Ppfia2 Ppfia3 Ppfia4 Bzrap1 Syn1 Apba1 Lin7b MET ACTIVATES RAS SIGNALING%REACTOME DATABASE ID RELEASE 66%10146212 MET activates RAS signaling Hgf Kras Muc20 Hras Nras Sos1 Ranbp10 Ranbp9 Shc1 Grb2 DAP12 SIGNALING%REACTOME DATABASE ID RELEASE 66%10145432 DAP12 signaling Kras Fyn Pik3r1 Vav3 Pik3r2 B2m Klrc2 Rac1 Pik3cb Trem2 Lat Plcg1 Tyrobp Hras Vav2 Nras Sos1 Lcp2 Shc1 Syk Grb2 GAB1 SIGNALOSOME%REACTOME DATABASE ID RELEASE 66%10145248 GAB1 signalosome Gab1 Ptpn11 Src Csk Pik3r1 Pxn Egfr Grb2 RIPK1-MEDIATED REGULATED NECROSIS%REACTOME%R-RNO-5213460.1 RIPK1-mediated regulated necrosis Faslg Cflar Fadd Birc3 Birc2 Mlkl Ripk3 Traf2 Ripk1 Tradd Xiap Tnfsf10 Casp8 Fas REGULATION OF PTEN GENE TRANSCRIPTION%REACTOME%R-RNO-8943724.1 Regulation of PTEN gene transcription Eed Rbbp7 Mecom Hdac1 Lamtor3 RragB Phc1 Phc2 Sall4 Mtor Scmh1 Cbx4 Cbx2 Rheb Lamtor2 Cbx8 Lamtor1 Cbx6 Rptor Lamtor4 Bmi1 Hdac2 Rnf2 Lamtor5 Mbd3 Mlst8 Ring1 Hdac1l Chd3 Chd4 Rraga Phc3 Rragc Rragd Slc38a9 Mta3 Ezh2 Mta1 Mta2 Gatad2a Maf1 Gatad2b AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1%REACTOME DATABASE ID RELEASE 66%10145450 Autodegradation of the E3 ubiquitin ligase COP1 Psmc6 Psmb10 G6pc Psmb8 Psmb9 Psmb4 Psmb11 Psmb5 Psmf1 Psmb6 Psmd4 Psmb2 Psmd5 Psmd8 Psmb7 Psmd9 Psmb1 Psmb3 Psma8 Psmd11 Psmd12 Psmd13 Psmd14 Atm Psma5 LOC100910954 Psma2 Psmc3 Psmc5 Psmd2 Psma1 Psma4 Psmc1 Psma3 Psmc4 Psmc2 Psma6 Psme1 Psmd1 Psme2 Psmd7 Psmd3 Rfwd2 Psmd6 GENE EXPRESSION (TRANSCRIPTION)%REACTOME DATABASE ID RELEASE 66%10144751 Gene expression (Transcription) Thoc5 Rfc2 Thoc7 Thoc3 Gtf2h1 Thoc2 Gtf2h2 Bdp1 Usp7 Thoc1 Nrbf2 Zfp28-ps1 Zfp445 Myo1c Banp Zfhx3 Rarg Esr2 Mnat1 Thoc6 Rbx1 RGD1565904 Nr2c2ap Ice2 Hnf4a Zc3h8 Polr2g Hnf4g Polr2h Zfp473 Polr2e Nr4a3 Polr2f Nr4a1 Polr2j Nr4a2 Polr2k LOC685619 Polr2d Zfp212 Polr2i Zfp418 Polr2b Ddx39a Polr2c Zfp213 Ddx39b Polr2a Zfp867 Actl6a Ice1 Chtop Esrra Esrrb LOC100912534 Triap1 Actb Elf1 Sumo1 Ell Elf2 Rpa3 Tp53bp2 Nr6a1 Nr2c2 Nr2c1 Atp5c1 Iws1 Tcea1 Zkscan1 Pcna Zfp263 Zfp266 Taf7l Zfp496 Ccnh LOC102555919 Mapkapk5 Rara Rarb Yap1 Zfp498 Tead2 Pidd1 Tead1 Nr2e1 Ube2i Zfp483 Nr2f6 Gtf2h3 Rfc5 Nr2f1 Rfc4 Zfp287 Rfc3 LOC691135 Nr2e3 Gtf2h5 Zfp282 Gtf2h4 Zfp786 Aff4 Actl6b Zfp770 Smarce1 Zfp771 Zfp354c Pbrm1 Gtf2e1 Tceb3 Arid1b Zfp354a Arid1a Zfp791 Polr3d Gtf2e2 Zfpm1 Polr3c Cdk4 Polr3a Akt1 Polr3e Polr3b Supt6h Smarcd1 LOC102554302 Ercc3 Polr3h Smarcd2 Ercc6 Polr3k Smarcd3 Brpf3 Nuak1 Rpa1 Foxp3 Ccnd1 Polr3g Rpa2 Brpf1 Polr3f LOC100363472 LOC100911822 Brd1 Taf7 Nr1i3 Cpsf3l Ercc2 Taf3 Taf6 Kat6a Taf5 Ing5 Taf8 Zfp202 Tp53inp1 Zfp839 Zfp420 LOC100911519 Tbx5 Rxrg Runx2 Tp63 Nrbp1 Yaf2 Zfp426 LOC102553866 Fyttd1 Nelfe Nelfa Nelfb Gtf2b Znf740 Cradd Bnip3l Gtf3a Asun Slc25a16 RGD1562299 Znf750 Ssrp1 Mbd2 L3mbtl1 L3mbtl2 Zfp775 Zfp777 Dek LOC361990 Ints4 Ints5 Map2k6 Ints6 Ints7 Ints9 Zfp746 Phax Zfp583 Ints1 Ints3 Ints2 Zfp180 Zfp189 Dyrk2 Cul1 Epc1 Zfp804b Zfp703 Tp53rk LOC100911224 Zfp707 Zfp710 Supt16h Tnrc6b Zfp711 Mterf Tnrc6a Tnrc6c Krba1 Ssu72 Zfp566 Zfp169 Zfp167 Vwa9 Zfp383 Rrn3 Zfp37 Zfp113 Zfp110 Zfp382 Zfp112 Zfp46 Zfp398 Zfp111 Trim28 Zfp394 Zfp2 Sarnp Zfp317 Zfp597 Zfp74 LOC501406 Zfp9 Zfp1 Zfp84 Nabp1 Nabp2 Rslcan18 Serpinb13 Slu7 Zfp90 Zim1 Zfp641 Zfp647 LOC102549842 LOC102555083 LOC102546354 Auts2 Pax5 LOC102553962 Mga Zfp668 Snapc3 Snapc4 Mybbp1a Lsm10 Lsm11 Zfp667 Prelid1 Psmb7 Taf11 Psmb1 LOC679894 Taf15 Zfp248 Esrrg Taf13 Taf12 Mllt1 Rrp8 Taf4b Rpap2 Nr0b1 Ddx21 Noc2l Nr0b2 Gtf3c6 Gtf3c5 Gtf3c1 Poldip3 Max Psma5 Gtf3c3 Parp1 Gtf3c4 Supt4h1 Pou4f2 Cdk7 Zfp286a Hipk1 Polr3gl E2f6 Zfp324 Brf1 Psma2 Brf2 Slbp Brd2 Psmd2 Zfp697 Zfp612 Zfp692 Zfp691 Snapc5 Psmc2 Snapc2 Ppp1r13b LOC100910137 Psmd1 Ppp1r13l Psmd7 Zfp606 Ttc5 Zfp688 Rorb Psmd3 LOC100910121 Psmd6 Snrpf Wdr33 Gata2 LOC100911167 Tal1 Ldb1 Tp73 Gata1 Lmo2 Lmo1 Atrip Cdk2 Rad1 Atr Rad17 Setd8 Rad9a Suv39h1l1 Rad9b Rbbp5 Srsf3 Upf3b U2af2 Papola Srsf6 Hus1 Srsf7 Srsf4 Srsf5 Tfap2a Srsf2 Ppp2cb Ppp2ca Skp1 Srsf9 Ppp2r1a Dhx38 Clp1 Magoh Phc1 Phc2 Ncbp2 Srsf1 Ncbp1 Tfap2b Tfap2c Ppp2r1b Cstf2t Eif4a3 Sympk Tfap2d Tfap2e LOC100910660 Srrm1 Mapk14 Cdc40 Mapk11 Snrpb Rxra Pparg Prmt5 Prmt6 Hist1h2bo Hist1h2bcl1 Scmh1 Cbx4 Hist2h3c2 Cbx2 Hist1h2bk Cbx8 H3f3b Cbx6 Bmi1 Hdac2 Rnf2 Mbd3 Ring1 Smarca4 Chd3 Smarca2 Chd4 LOC100911617 Phc3 Arid2 Smarcc1 Smarcc2 Mta3 Smarcb1 Mta1 Mta2 Gatad2a Gatad2b Meaf6 LOC100909949 Eed LOC100910200 H2afx Hist1h4b Wdr5 Phf19 Kmt2a LOC684841 Smyd2 Hist1h2bh Dnmt1 LOC100912290 Rbbp7 Hist1h2ail1 Hist1h4m LOC102549173 Ehmt2 LOC103690002 LOC100910152 Ehmt1 Dnmt3a LOC100912338 Hist1h3c H2afb3 Hist1h3f Dnmt3b Hist2h4 LOC684819 Hist1h3a H2afj Hist2h2aa3 Suv39h1 Hist1h2bq Hist2h2aa2 Mtf2 Ash2l Phf1 LOC100364835 Dpy30 LOC684762 Jarid2 Hist1h2bg Ezh2 LOC680097 LOC684797 LOC100912418 Hist1h2ba Hist3h2bb Aebp2 Paf1 Rtf1 Supt5h Rnmt Rngtt Skp2 Cdkn1a Cdkn1b Chm Gadd45a Bax Rnps1 Magohb Rbm8a Pcf11 Fip1l1 Rabggta Nudt21 Snrpd3 Aurka Cstf2 U2af1l4 Cpsf7 Cpsf2 Cpsf3 Cpsf4 Cstf1 Cpsf1 Rabggtb Sf3b1 Psmd11 Psmd12 Ccna2 Ctr9 Ccna1 Rffl Psmd13 Ccng1 Psmd14 Phf20 Atm Rictor Wdr61 Tceb2 Tceb1 Psmc3 Src Ywhah Ywhag Sfn Ywhaz Ywhab Ywhaq Ywhae Med1 Lamtor3 Tdg Cited1 Nr5a2 Gtf2f1 Gtf2f2 Lamtor2 Lamtor1 Gtf2a1 Bmyc Prmt1 Esr1 Pou2f1 Cbfb Gata3 Crebbp Pgr Tbp Runx1 Notch1 Kras Cdk13 Prkra Ago3 Dicer1 Csnk2b Usp2 Tsnax Ago4 Ago2 Daxx LOC100910954 Cdk1 Mdm4 Tsn Chek2 Tarbp2 Taf10 Rnf34 Mapkap1 Sgk1 Ptpn11 Notch2 Taf9b Mdm2 Notch3 Cdk5 RGD1308751 Leo1 Pml Cited2 Brca1 Blm Pcgf2 Hdac4 Ppm1d Rbm14 LOC100911677 Sox9 Thra Thrb Smad3 Ing2 Ccnt2 Smad2 Nr1h3 Nr1h2 Usp9x Sp1 Ube2d1 Skil Rbl1 Ncor2 Nr5a1 Cdk9 Rora Nr1i2 E2f4 Hdac1 Tgif2 Tgif1 LOC100911274 Atp1b4 Trim33 Ccnk Ube2d3 Wwtr1 Tfdp1 Tfdp2 Stub1 MGC114246 Testin LOC100364523 Cdk5r1 Ctsl Ctsm Ctsj RGD1564657 Ctsk Ctsq Ctsr Cts8 Cts7 RGD1564827 Rhno1 Bard1 Wrn Topbp1 Rbbp8 Rmi1 Rmi2 Rad50 Lhb LOC364561 Pin1 Brd7 Sesn2 Plk2 Txnrd1 Ccne2 Sesn1 Plk3 RragB Ccne1 Prkab1 Sesn3 Prkab2 Gsr Cts8l1 E2f7 E2f8 Btg2 Cnot6l Cnot11 Tgfb1 Tmem55b Pip4k2b Nbn Cga Pip4k2c Mre11a Tnks1bp1 Cnot8 Rqcd1 Cnot3 Cnot1 Cnot2 Cnot7 Cnot4 Mtor Prdx1 Ddit4 Rheb Prkag3 Rptor Lamtor4 LOC502894 Tsc1 Lamtor5 Txn1 Sin3a Mlst8 Sin3b Prkaa1 Tsc2 Rraga Prkaa2 Rragc Akt3 Rragd Slc38a9 Smurf1 E2f5 Hdac1l Snw1 Zfp385a Smarca5 Cdk6 Cdc73 Atad2 Ccnd3 Cenpj Cited4 Yeats4 Tcf7 Lef1 Tcf7l1 Nr1h4 Maml1 Rbpj Kat2a Rbpjl2 Csnk2a2 Csnk2a1 LOC100909750 Vdr Nup88 Hipk2 Nup85 Rae1 Nup93 Nup98 Nup107 RGD1306195 Nup210 Ubtf Polr1b Taf1d Taf1c Cd3eap Znrd1 Ppara Polr1c Polr1a Nupl2 Ppard Nupl1 Ptrf Ttf1 Cdc25c Aurkb Nup205 Abl1 G6pc Nup155 Men1 Polrmt Ppp2r5c Tfam Gpi Tfb2m Nup153 Tpr Twistnb Pdpk1 Polr1e Nup54 Pom121 Nup62 Psmc6 Psmb10 Nup43 Nup133 Psmb8 Psmb9 Psmb4 Psmb11 Aaas Psmb5 Psmf1 Psmb6 Psmd4 Psmb2 Psmd5 Npap60 Psmd8 Psmd9 Psmb3 Nup35 Psma8 Nup37 Ranbp2 Akt2 Nr1d1 Pcgf6 Rprd1a Nr1d2 Pcgf5 Notch4 Cdk12 Eaf1 Eaf2 Taf2 Zfp14 Slmo1 Taf9 RGD1562871 Ell3 Zfp12 Ell2 Casp2 Zfp13 Rprd1b Zfp28 Baz1b Zfp18 Tpx2 Psmc5 Psma1 Psma4 Psmc1 Psma3 Psmc4 Psma6 Psme1 Psme2 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES%REACTOME%R-RNO-450282.1 MAPK targets Nuclear events mediated by MAP kinases Dusp3 Dusp4 Vrk3 Rps6ka2 Rps6ka1 Jun Rps6ka3 Rps6ka5 Ppp2cb Ppp2ca LOC100912585 Ppp2r1a Dusp7 Dusp6 Atf1 Atf2 Mapk9 Mapk8 Fos Mapk7 Ppp2r1b Mapkapk2 Mapk1 Creb1 Mapk14 Mapk11 Mapk10 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER%REACTOME%R-RNO-76071.1 RNA Polymerase III Transcription Initiation From Type 3 Promoter Bdp1 Polr3d Snapc3 Snapc4 Polr3c Polr3a Polr3e RGD1565904 Polr3b Polr3h Polr2h Polr3k Polr2e Polr2f Polr3g Polr1c Polr3f Polr2k LOC100912534 Polr3gl Brf2 Pou2f1 Snapc5 Snapc2 Tbp HSF1-DEPENDENT TRANSACTIVATION%REACTOME%R-RNO-3371571.1 HSF1-dependent transactivation Mtor Camk2g Hsbp1 Dnajb1 Cryab Rptor Hsf1 Hspb8 Hspa1l Akt1s1 Hsp90ab1 Hspa2 LOC103692716 Ptges3 Mlst8 Camk2d Camk2a Ptges3l1 Fkbp4 Crebbp DOWNSTREAM TCR SIGNALING%REACTOME DATABASE ID RELEASE 66%10145375 Downstream TCR signaling Psmc6 Pten Psmb10 Psmb8 Psmb9 Psmb4 Psmb11 Psmb5 Psmf1 Psmb6 Psmd4 Traf6 Psmb2 Cul1 Psmd5 Psmd8 Psmd9 Psmb3 Psma8 Psmd11 Cdc34 Psmd12 Cd4 Psmd13 Rela Psmd14 Map3k7 Prkcq Psmc3 Nfkbia LOC100910771 Ube2n Bcl10 G6pc Pik3r1 Pik3r2 Ube2d1 Psmb7 Inpp5d Psmb1 Cd3e RT1-Ba RT1-Bb Skp1 RT1-Da RT1-Db2 RT1-Db1 LOC688090 Nfkb1 Cd247 Psma5 Fbxw11 Chuk Btrc Pdpk1 Psma2 Psmc5 Pik3cb Cd3g Psma1 Psmd2 LOC100362142 Psma4 Psmc1 Cd3d Psma3 Psmc4 Psmc2 Tab2 Psma6 Psme1 LOC100912618 Ube2v1 Psmd1 Psme2 Ikbkb Psmd7 Psmd3 Psmd6 P75NTR RECRUITS SIGNALLING COMPLEXES%REACTOME%R-RNO-209543.1 p75NTR recruits signalling complexes Ripk2 Prkci Sqstm1 Ngf Ngfr Ikbkb Myd88 Traf6 CHOLESTEROL BIOSYNTHESIS%REACTOME%R-RNO-191273.1 Cholesterol biosynthesis Ppapdc2 Msmo1 Arv1 Sqle Hmgcs1 Dhcr7 Acat2 Ggps1 RGD1564347 Sc5d Tm7sf2 Cyp51 Nsdhl Mvd Hmgcr Ebp Pmvk Dhcr24 RGD1562948 Fdft1 MEMBRANE TRAFFICKING%REACTOME DATABASE ID RELEASE 66%10145299 Membrane Trafficking Kif21a Kif21b Kifc1 Kif3c Racgap1 Kif22 Kif3b Kif23 Kif18b Kifap3 Kif11 Egfr Kif12 Kif4a Kif6 Kif1a Kif1c Dnm2 Kif27 Kif9 Kif13b Cops8 Cops2 Nedd8 Akt1 Cops4 Cops6 Myo6 Cops3 Kif20b Kif16b Kif26a Kif20a Kif26b Kif19 Galnt1 Galnt2 App Cd59 Arf6 Rab3ip Vamp8 Gdi2 Sar1b Stam2 Sh3gl2 Apob Sh3gl1 Sh3kbp1 Sh3gl3 Stam Rab4a Ank1 Ctsc Ctsz Itsn1 Spta1 Dnm1 Dnm3 Sptbn1 Cops7b Cops7a Snap29 Pla2g6 Rab8a Tgfa Alpp Alpi Kif3a Col7a1 F8 Scfd1 Tsc1 Tsc2 Akt3 Pik3c2a Bnip1 Rabgap1 Madd Rin3 Clvs1 Snx18 Chmp2b Chmp2a Use1 Rgp1 Hip1r Pla2g4a LOC100909679 Ulk1 Sbf2 Ap1m2 Mvb12b Mvb12a Snx5 Stx16 Snx9 Fnbp1l Snx2 Chmp4b Stx18 Chmp4c Golga5 Gapvd1 Golga1 Golga4 Dennd3 Acbd3 Sort1 Dnase2 Tbc1d10a Clint1 Tsg101 Tbc1d10b Cbl Yipf6 Ap4s1 Vta1 Hip1 Hps4 Tpd52 LOC100910792 Hps1 Mon1b Mon1a Cyth1 Cyth4 Cyth3 Cyth2 Trip11 Dennd1a Nbas Trappc12 Trappc11 Dennd1b Dctn1 Dctn2 Dctn3 Rab11a Csnk1d Arrb1 Arrb2 Adrbk1 Actr1a Klc1 Sec24a Dync1li2 Sec24b Copa Sec24d Sbf1 Dync1i2 Gja10 Gjd2 Syt1 Vamp2 Man1c1 Gjc1 Klc4 Man1a1 Cenpe Klc2 Klc3 Chmp4bl1 Cog4 Cttn Cog6 Gcc1 Cog8 Amph Cog3 Gja5 Rhobtb3 Pafah1b1 Cpd Cog1 Gja3 Cog2 Gja8 Usp6nl Gja4 Sec23ip Rala LOC100361515 Lman1l Gjb6 Scoc Cog7 Ap1b1 LOC102555167 Gjb2 Stx6 Dynll2 Vps37a Gjb3 Gjb4 Rab39a Vps37d Vps37c Stx4 Dync1i1 Rab11b Vps37b Gjc2 Tbc1d1 Tbc1d2 Ykt6 Tbc1d7 Sec24c Rabepk Gabarap Vps45 Bin1 Tmed7 Ubap1 Tmed3 Vps53 Vps52 Tmed2 Cux1 Ap4e1 Gjd4 Arfip2 Vps54 Rab6b Rab9a Ap4b1 Napg Ap1g2 Napb Ric1 Synj1 Napa Fnbp1 Vps4b Ccz1b Tpd52l1 St5 Snapin Rab3gap2 Tmed9 Dennd6b Dennd6a Ap3b1 Bicd2 Synj2 Vps25 Nsf Bicd1 Chmp5 Alppl2 Chmp7 Golim4 Bloc1s3 Snf8 Vps36 Chmp6 Rab8b Chmp3 Pum1 Arl1 Dennd5a Ap4m1 Bloc1s4 Gabarapl2 Agpat3 Bloc1s1 Bloc1s6 Rab3il1 LOC100910929 Chm Arfrp1 Trappc8 Dennd4a Dennd4b Arcn1 Pacsin2 Rab7b Pacsin3 Tbc1d13 Tbc1d16 Tbc1d15 Tbc1d17 Sytl1 Dennd2a Dennd2d Rab33a Dennd2c Rab33b Trappc13 Ap1s3 Ap1s1 Plin3 Ap1s2 Tbc1d25 Gak Pafah1b3 Tbc1d14 Trappc10 Rab35 Rab36 Ppp6c Trappc2l Rab43 Pip5k1c Rab21 Trappc6a Trappc6b Rab12 Rab13 Ankrd28 Rab32 Sec13 Rab30 Rab38 Rab1b Wasl Rab1a Tmem115 Ocrl Arfgap2 Arpc4 Golgb1 Arpc3 Arfgap3 Kif2a Arfgap1 Kif2c Kif2b Kif18a Mcfd2 Preb Capzb Kif5b Kif5a Actr3 Sec31a Stx17 Dvl2 Gosr2 Gosr1 Zw10 Tmed10 Areg Stx5 Ftl1 Bet1 Arf5 Cnih1 Igf2r Arf4 Ctage5 Rab27a Gbf1 Cnih3 Cnih2 Ap2a2 Man2a1 Man2a2 Copz2 Copz1 Lman2 Sec16a Sec16b Lman1 Trappc2 Gja1 Trappc5 Src Rab27b RGD1561661 Rab3a Copb1 Wnt5a Cltc Rab7a Cltb Tfg Clta Fzd4 Ywhah Ywhag Sfn Ap2s1 Ywhaz Ywhab Ap2a1 Ywhaq Ywhae Trappc3 Ap2m1 LOC100910318 Rab5b Kdelr1 Rab5c Tbc1d20 Capza2 Capza3 Rab6a Kdelr2 Gjb1 Rab9b Ppp6r3 Ppp6r1 Trappc1 Kdelr3 Agtr1b Agtr1a Syt11 Aak1 Sgip1 Eps15l1 LOC100909548 Itsn2 Scarb2 LOC100910557 Necap1 Agfg1 Snap91 Ubqln2 Sptan1 Picalm Tgoln2 Ldlr Rab18 Tor1a Ston2 Tfrc RGD1307443 Rab10 Tf Rab14 Chrm2 Necap2 Cd4 Actr10 Tor1b Avp Dab2 Ston1 Dync1h1 Dync1li1 Copg1 Dctn5 Dctn6 Ins1 Ins2 Dctn4 Folr1 Akt2 Uso1 Gorasp1 Ap1m1 LOC100360087 Txndc5 Actr2 Sec22b Cope Sec23a Sec22a Cd3g Slc2a8 Syt8 Cd3d Syt9 Arpc5 Syt2 Fcho2 Man1a2 Fcho1 M6pr Ldlrap1 Vamp4 Vamp3 Optn LOC100363782 Adrb2 Tbc1d10c Vamp7 Tacr1 Grb2 HIGHLY CALCIUM PERMEABLE NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%R-RNO-629597.1 Highly calcium permeable nicotinic acetylcholine receptors Chrnb4 Chrna4 Chrna5 Chrna6 Chrnb2 Chrnb3 Chrna2 Chrna3 Chrna1 PHASE 1 - INACTIVATION OF FAST NA+ CHANNELS%REACTOME DATABASE ID RELEASE 66%10146070 Phase 1 - inactivation of fast Na+ channels Kcnd3 LOC100911951 Kcnd1 Kcnip3 Kcnip4 Kcnip2 TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR%REACTOME DATABASE ID RELEASE 66%10145903 Trafficking and processing of endosomal TLR Tlr7 MGC114246 Tlr8 Cts8l1 Lgmn Cnpy3 LOC100364523 Unc93b1 RGD1308751 Testin Ctsb Tlr3 Hsp90b1 Ctsl Cts8 Cts7 Tlr9 Ctsm Ctsj RGD1564657 RGD1564827 Ctsk Ctsq Ctsr INTEGRATION OF ENERGY METABOLISM%REACTOME%R-RNO-163685.1 Integration of energy metabolism Plcb1 Cacna1e Slc25a5 Adipor1 Adipor2 Marcks Adipoq Plcb3 Ffar1 Gnaq Gna11 Acly Gna14 Gna15 Prkab2 Tkt Adcy5 Adcy6 Prkar1b Prkar1a Gcgr Kcnj11 Abcc8 Gng10 Fasn Acacb Cacna1c Cacna1d Prkar2b Prkar2a Slc2a2 Adra2a Taldo1 Agpat1 Gnai2 Adra2c Gnb3 Rap1a Gnb5 Kcnc2 Gnb2 Gnb1 Gng13 Gng12 Gng11 Prkaa2 Prkaca Prkacb Itpr1 Cacnb2 Kcns3 Rapgef4 Itpr3 Prkca LOC100912034 Slc2a1 Gnb4 Glp1r Gcg Gng4 Cacna2d2 Gngt2 Gnai1 Gng5 Gngt1 Gng8 Gng3 INTERLEUKIN-10 SIGNALING%REACTOME DATABASE ID RELEASE 66%10145687 Interleukin-10 signaling Il10ra Il10 Jak1 Stat3 Il10rb Tyk2 MITOTIC ANAPHASE%REACTOME DATABASE ID RELEASE 66%10145224 Mitotic Anaphase Cenpn Psmc6 Zwilch Cenpl Nup43 Cenpo Psmb10 Nup133 Dync1li2 Psmb8 Cenpt Psmb9 Cenpu Psmb4 Psmb11 Bub3 Bub1 Psmb5 Psmf1 Psmb6 Spdl1 Psmd4 Kntc1 Psmb2 Dync1i2 Psmd5 LOC100910252 Psmd8 Mad1l1 Stag1 Psmd9 Psmb3 Psma8 Cenpk Cenph Nup37 Cenpi Psmd11 Psmd12 Pds5b Pds5a Cenpf Cdca5 Psmd13 Rad21 Cenpe Psmd14 Smc1a Cenpm Stag2 Smc3 Ahctf1 Ndel1 Rcc2 Pafah1b1 Mis12 Dynll2 Psmc3 Ndc80 Cenpc Cenpa Dync1i1 Ranbp2 Birc5 Taok1 Ube2d1 Ppp2cb Ppp2ca Ppp2r1a Nup85 Anapc7 Cdc26 Cdc27 Cdc23 Pttg1 Ube2c Anapc16 Ppp2r1b Cdc16 Anapc4 Anapc2 Anapc1 Nup98 Nup107 Anapc11 Anapc15 Anapc10 Dync1h1 Cdca8 Dync1li1 Rangap1 Ppp1cc LOC100909468 Aurkb Sec13 Xpo1 LOC100911204 Spc24 Spc25 Hdac8 Itgb3bp Sgol2 Ppp2r5e Incenp G6pc Nsl1 B9d2 Cdc20 Kif2a Kif2c Kif2b Vrk2 Psmb7 Bub1b Psmb1 Kif18a Ppp2r5c Vrk1 Ppp2r5a Ppp2r5b Zwint Dsn1 Espl1 Mad2l1 Casc5 Clasp2 Ercc6l Psma5 Nuf2 Clasp1 LOC679582 Psma2 Mapre1 Psmc5 Psma1 Pmf1 Psmd2 Psma4 Psmc1 Psma3 Psmc4 Psma6 Ckap5 Psmc2 Psme1 Ska2 Psme2 Psmd1 Psmd7 Sgol1 Zw10 Psmd3 Ska1 Psmd6 ZINC EFFLUX AND COMPARTMENTALIZATION BY THE SLC30 FAMILY%REACTOME DATABASE ID RELEASE 66%10145653 Zinc efflux and compartmentalization by the SLC30 family Slc30a5 Slc30a6 Slc30a8 Slc30a1 GABA A RECEPTOR ACTIVATION%REACTOME%R-RNO-977441.1 GABA A receptor activation Gabra5 Gabra6 Gabrb1 Gabrg2 Gabra1 Gabra2 Gabra4 Gabrb2 INTESTINAL ABSORPTION%REACTOME DATABASE ID RELEASE 66%10145282 Intestinal absorption Slc2a5 Npc1l1 Slc2a2 Slc5a1 DEADENYLATION-DEPENDENT MRNA DECAY%REACTOME%R-RNO-429914.1 Deadenylation-dependent mRNA decay LOC100912571 Eif4g1 Wdr61 Lsm7 Lsm6 Lsm4 Lsm3 Lsm5 Cnot6l Pabpc2 Lsm2 Cnot11 Pabpc6 LOC679753 Eif4a2 Eif4a1 LOC680559 LOC100360750 Dcp2 Exosc3 Tnks1bp1 Hbs1l Dcp1a Dcps Exosc9 Cnot8 Exosc2 Lsm1 Rqcd1 Exosc1 Nt5c3b Pan2 Exosc4 Cnot3 Patl1 Cnot1 Ttc37 Exosc7 Zcchc6 Edc3 Exosc5 Edc4 Cnot2 LOC100911431 Pabpc1 Cnot7 Cnot4 Dcp1b Eif4b Eif4a3 EPH-EPHRIN MEDIATED REPULSION OF CELLS%REACTOME%R-RNO-3928665.1 EPH-ephrin mediated repulsion of cells Src Fyn Tiam1 Aph1b Ephb1 Psenen Ephb2 Mmp9 Vav3 Aph1a LOC100911293 Psen2 Psen1 Mmp2 Rac1 Ncstn Ephb4 Lyn Ephb3 Vav2 Efnb2 Yes1 Efnb1 Efnb3 ADRENALINE SIGNALLING THROUGH ALPHA-2 ADRENERGIC RECEPTOR%REACTOME DATABASE ID RELEASE 66%10145560 Adrenaline signalling through Alpha-2 adrenergic receptor Adra2a Adra2c Adra2b MINERALOCORTICOID BIOSYNTHESIS%REACTOME%R-RNO-193993.1 Mineralocorticoid biosynthesis Lhb Hsd3b1 Hsd3b Hsd3b2 LOC100911154 Cyp21a1 Cga Cyp11b2 BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 66%10144858 Base Excision Repair Rfc1 Rfc2 Pole2 Pole4 Rpa1 Rpa2 Lig1 Tdg Mpg Neil1 Ogg1 Xrcc1 Neil2 Mbd4 Parp2 Smug1 Rpa3 Parp1 Pnkp Lig3 LOC100911727 Pole Polb Pold2 Nthl1 Pcna Pold1 Mutyh Pold4 Fen1 Adprhl2 Ung Parg Rfc5 Apex1 Rfc4 Rfc3 INTERLEUKIN-2 FAMILY SIGNALING%REACTOME DATABASE ID RELEASE 66%10145686 Interleukin-2 family signaling Stat5a Jak3 Csf2ra Csf2rb Il21r Stat1 Il2rg Il21 Ptk2b Pik3r3 Pik3r1 Jak1 Pik3r2 Stat3 Il5ra Inpp5d Pik3cd Il9r Il15 Il9 Sos2 Pik3cb Il5 Il2 Ptpn6 Il2ra Csf2 Il3ra Sos1 Shc1 Syk Grb2 Il2rb POST-TRANSLATIONAL PROTEIN PHOSPHORYLATION%REACTOME DATABASE ID RELEASE 66%10146280 Post-translational protein phosphorylation Hrc Mbtps1 Fuca2 Shisa5 Mfi2 Bpifb2 Vwa1 Sdc2 Amtn Cyr61 Csf1 Serpind1 Wfs1 Chgb Igfbp1 Igfbp5 Mgat4a Igfbp4 Enam LOC100909521 Kng1l1 Afp Serpinc1 Bmp4 Mfge8 Igfbp7 Notum Calu Bmp15 Aplp2 Mepe Apoa1 Timp1 Pcsk9 Dmp1 Amelx Prkcsh Pnpla2 Fam20c Tmem132a Mxra8 Lgals1 Nucb1 Fam20a Ambn Tgoln2 Gas6 Fgf23 Apol2 Hsp90b1 App RGD1309808 Msln Lamc1 Tf Apol11a Apol3 LOC100910885 Vgf Apol9a Fbn1 Fstl1 Stc2 Fstl3 Prss23 Fgg Apob Chrdl1 Apoe Fga Apoa2 Cst3 Lamb1 Lamb2 Qsox1 Scg2 Spp1 C4a Scg3 C4b Il6 Ktn1 LOC100909666 Sparcl1 LOC102549354 Men1 Penk LOC100911615 Kng1 Rcn1 Eva1a Kng2 Fn1 Vcan P4hb Cdh2 Dnajc3 C3 Ltbp1 Ckap4 Serpina10 Cp CELLULAR RESPONSES TO STRESS%REACTOME%R-RNO-2262752.1 Cellular responses to stress Hif1an Dync1li2 Mdm2 Vhl Rbx1 Dync1i2 Rpa3 Ncf1 Ncf4 Cited2 Dynll2 Mapkapk5 Dync1i1 Ube2d1 Cdk4 Nup88 Rpa1 Rpa2 Ube2d3 Nup85 Anapc7 Cdc26 Cdc27 Cdc23 Ube2c Cdkn1a Cdkn1b Anapc16 Cdc16 Rae1 Anapc4 Anapc2 Anapc1 Map2k7 Nup93 Dnaja2 Asf1a Camk2g Map2k6 Dnajb6 Dnaja4 Nup98 Ets1 Map2k4 l7Rn6 Nup107 Ep400 Ets2 Tnik Fkbp5 LOC100911837 LOC100910067 Sod1 Camk2d Sod3 Mink1 Camk2a Nup210 Map3k5 Txnrd2 Rps6ka2 Nudt2 Rps6ka1 Hspa14 Hspa13 Rps6ka3 Nox4 Erf LOC100912585 Ubn1 Dnajc7 Anapc11 Nupl2 Anapc15 Cabin1 Hdac6 Anapc10 Nupl1 Ccar2 Hira Fzr1 Hsph1 Hspa12b Hspa12a Nup205 G6pc Nup155 Psmb7 Psmb1 Sod2 Capzb Nup153 P4hb Psma5 Tpr Psma2 Psmd2 Nup54 Psmc2 Pom121 Psmd1 Psmd7 Nup62 Prdx6 Psmd3 Psmd6 Psmc6 Nup43 Psmb10 Nup133 Psmb8 Psmb9 Psmb4 Aaas Psmb11 Psmb5 Psmf1 Psmb6 Rad50 Psmd4 Psmb2 Psmd5 Npap60 Psmd8 Psmd9 Psmb3 Nup35 Psma8 Nup37 Psmd11 Psmd12 Ccna2 Ccna1 Ccne2 Txnrd1 Psmd13 Psmd14 Ccne1 Atm Gsr Cdk2 Egln2 Tceb2 Tceb1 Cul2 Hif1a Limd1 Psmc3 Atr Epas1 Hif3a Egln3 Ajuba Ranbp2 Nbn Mre11a Hsbp1 Dnajb1 Cryab Hsf1 Hspb8 Hspa1l Hsp90ab1 Akt1s1 Hspa2 Cat Jun Ero1l Ywhae Phc1 Phc2 Bag1 Mtor Bag2 Prdx1 Bag4 Mapk9 Bag5 Mapk8 Gpx8 Fos Gpx7 Rptor Bag3 Mapk7 Gpx6 Hspa9 Hspa5 Capza2 Txn1 Prdx3 Capza3 Stip1 Mlst8 Id1 Mapkapk3 Map4k4 Hspa4 Mapkapk2 Ccs Mapk1 Mapk14 Mapk11 Mapk10 Vcp Actr10 Hist1h2bo Dync1h1 Tinf2 Hist1h2bcl1 Scmh1 Hist2h3c2 Cbx4 Hist1h2bk Cbx2 Cbx8 H3f3b Cbx6 Bmi1 Dync1li1 Rnf2 Kdm6b LOC103692716 Ring1 Ptges3 Cybb Cyba Phc3 Ptges3l1 Dctn5 Dctn6 Cdkn2b Terf2ip Fkbp4 Crebbp Dctn4 Cdkn2c Pgr Cdk6 Dctn1 Eed LOC100910200 Txn2 H2afx Dctn2 Hist1h4b Gstp1 LOC684841 Hist1h2bh Acd LOC100912290 Rbbp7 Pot1b Hist1h2ail1 Hist1h4m LOC102549173 LOC103690002 Dctn3 Ehmt2 LOC100910152 Pot1 Ehmt1 LOC100912338 Hist1h3c H2afb3 Hist1h3f Hist2h4 LOC684819 Hist1h3a H2afj Hist2h2aa3 Hist1h2bq Hist2h2aa2 LOC100364835 LOC684762 Terf1 Terf2 LOC100910954 Arnt Mdm4 Psmc5 Psma1 Psma4 Psmc1 Psma3 Psmc4 Psma6 Psme1 Hist1h2bg Psme2 Ezh2 LOC680097 LOC684797 Actr1a LOC100912418 Hist1h2ba Hist3h2bb RECYCLING OF BILE ACIDS AND SALTS%REACTOME%R-RNO-159418.1 Recycling of bile acids and salts Slco1a1 Nr1h4 Slco1a6 Stard5 Ncoa2 Slco1a4 Slco1a2 Rxra Baat Slco1b2 Fabp6 Slc10a1 Slc21a4 Slc27a5 Abcb11 Ncoa1 Slc10a2 METAL ION SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 66%10145650 Metal ion SLC transporters Slc30a5 Slc39a2 Slc11a1 Slc30a6 Slc39a3 Slc30a8 Slc39a4 Slc39a14 Slc39a6 Slc11a2 Slc31a1 Slc30a1 LOC100911874 Slc41a1 Heph Slc41a2 Slc40a1 Slc30a10 Slc39a7 Slc39a8 Cp UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D%REACTOME%R-RNO-75815.1 Ubiquitin-dependent degradation of Cyclin D Psmc6 Psmb10 G6pc Psmb8 Psmb9 Psmb4 Psmb11 Psmb5 Psmf1 Cdk4 Psmb6 Psmd4 Psmb2 Psmd5 Psmd8 Psmb7 Psmd9 Psmb1 Psmb3 Psma8 Ccnd1 Psmd11 Psmd12 Psmd13 Psmd14 Psma5 Psma2 Psmc5 Psmc3 Psma1 Psmd2 Psma4 Psmc1 Psma3 Psmc4 Psmc2 Psma6 Psme1 Psmd1 Psme2 Psmd7 Psmd3 Psmd6 SIGNALING BY FGFR4%REACTOME DATABASE ID RELEASE 66%10145262 Signaling by FGFR4 Src Kras Pik3r1 Frs3 Fgf23 Fgf22 Fgf4 Fgf1 Ppp2cb Fgf3 Ppp2ca Fgf6 Ppp2r1a Fgf5 Fgf20 Mknk1 Gab1 Fgf16 Fgf17 Fgf10 Fgf9 Fgfr2 Fgf2 Fgf7 Cbl Spry2 Fgf8 Fgfr3 Fgfr1 Mapk1 Fgfr4 Ptpn11 Plcg1 Fgf19 Hras Nras Frs2 Sos1 Shc1 Grb2 SODIUM CALCIUM EXCHANGERS%REACTOME DATABASE ID RELEASE 66%10145617 Sodium Calcium exchangers Slc24a4 Slc24a2 Slc24a5 Slc8b1 Sri Slc8a2 Slc8a3 Slc8a1 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE%REACTOME%R-RNO-174411.1 Polymerase switching on the C-strand of the telomere Rfc1 Rfc2 Prim2 Pola2 Prim1 Rfc5 Rfc4 Pold2 Rfc3 Pcna Pold1 Pold4 INTERLEUKIN RECEPTOR SHC SIGNALING%REACTOME%R-RNO-912526.1 Interleukin receptor SHC signaling Jak3 Csf2ra Csf2rb Il2rg Pik3r3 Pik3r1 Jak1 Pik3r2 Il5ra Inpp5d Pik3cb Il5 Il2 Ptpn6 Il2ra Csf2 Il3ra Pik3cd Sos1 Shc1 Grb2 Il2rb REGULATION OF KIT SIGNALING%REACTOME%R-RNO-1433559.1 Regulation of KIT signaling Src Fyn Ptpn6 Prkca Lyn Sh2b2 Yes1 Cbl Sos1 Kit Kitlg Grb2 TRAF6 MEDIATED NF-KB ACTIVATION%REACTOME%R-RNO-933542.1 TRAF6 mediated NF-kB activation Nfkb2 Nfkb1 Ager S100b Dhx9 Nfkbib Chuk Nkiras1 App Nfkbia Nkiras2 Rela Ikbkb Myd88 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS%REACTOME%R-RNO-450531.1 Regulation of mRNA stability by proteins that bind AU-rich elements LOC100912571 Psmc6 Psmb10 Psmb8 Psmb9 Psmb4 Psmb11 Psmb5 Psmf1 Psmb6 Psmd4 Psmb2 Psmd5 Psmd8 Psmd9 Psmb3 Psma8 Psmd11 Psmd12 Psmd13 Eif4g1 Psmd14 Pabpc2 Pabpc6 Psmc3 Xpo1 LOC680559 Prkcd Hspb1 RGD1563307 G6pc Dcp2 Elavl1 Exosc3 Akt1 LOC100911537 Xrn1 Dcp1a Psmb7 Psmb1 Exosc9 Exosc2 Exosc1 Exosc4 Exosc7 Exosc5 LOC100911431 Ywhaz Pabpc1 Ywhab Hnrpd Psma5 Mapkapk2 Psma2 Psmc5 Psmd2 Psma1 Psma4 Psmc1 Psma3 Psmc4 Psmc2 Prkca Psma6 Psme1 Psmd1 Psme2 Psmd7 Khsrp Anp32a Psmd3 Tnfsf13 Psmd6 ANDROGEN BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 66%10145322 Androgen biosynthesis Lhb Pomc Srd5a3 Hsd3b1 Srd5a1 Hsd3b Srd5a2 Hsd3b2 LOC100911154 Hsd17b3 Cga Hsd17b12 ACYL CHAIN REMODELLING OF PI%REACTOME%R-RNO-1482922.1 Acyl chain remodelling of PI Pla2r1 Plbd1 Pla2g5 Pla2g4e Pla2g4d Pla2g16 Pla2g2a Mboat7 Pla2g2f Pla2g10 Pla2g2d LOC103689982 Pla2g1b Pla2g4a LOC686302 Pla2g12a Pla2g4c Pla2g4cl1 GLUCURONIDATION%REACTOME%R-RNO-156588.1 Glucuronidation Ugt2b Ugt1a8 Ugdh Ugt2b37 Ugt1a9 Ugt1a6 Slc35d1 Ugt2b35 Ugt2a1 Ugt2b15 Ugp2 Ugt1a1 Ugt2b17 RGD1559459 Ugt1a7c Ugt1a5 Ugt1a3 Ugt1a2 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS%REACTOME%R-RNO-446219.1 Synthesis of substrates in N-glycan biosythesis Ctsa Mvd Fuom Slc35c1 Fuk Tsta3 Gmds LOC100911225 Fpgt St8sia1 Gfpt2 Nus1 Neu4 Dolpp1 Neu2 Gfpt1 St8sia3 Neu3 Neu1 Renbp St3gal5 Mpi Pgm3 Pmm2 Pmm1 Srd5a3 Nans Slc35a1 St8sia5 Slc17a5 St6galnac1 St6galnac2 Nudt14 Npl LOC501189 Dhdds Cmas St8sia4 Nanp LOC100910177 Dolk St6gal1 St6gal2 Glb1 Amdhd2 St6galnac4 St3gal2 St6galnac3 St3gal3 Nagk Gne St3gal1 St6galnac6 Gnpnat1 Dpm3 Dpm2 St3gal4 Dpm1 St3gal6 Uap1 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION%REACTOME%R-RNO-983231.1 Factors involved in megakaryocyte development and platelet production Kif21a Kif21b Kifc1 Kif3c Dock5 Racgap1 Klc1 Dock3 Kif22 Kif3b Rad51c Kif23 Sh2b1 Kif18b Rcor1 Kifap3 Dock9 Kif11 Dock8 Dock6 Kif12 Kif4a Mical1 Rac1 Kif6 Lrrc16a Kif1a Akap1 Kif1c Gata4 Gata2 LOC100911167 Kif27 Klc4 Kif9 Kdm1a Cenpe Kif13b Klc2 Gata1 Klc3 Prkar1b Prkar1a Mfn1 Mfn2 LOC100911485 Kif3a Dock11 Ehd3 Ehd2 Ehd1 Hmg20b Phf21a Mafk Mafg Maff Cbx5 Nfe2 Akap10 Ak3 Rbsn Jmjd1c Zfpm2 LOC100909609 Zfpm1 Dock7 Hdac1 Capza2 Kif20b Prkaca Prkacb Kif16b Kif26a Kif20a Kif26b Kif19 Dock1 Sh2b2 Itpk1 Hist2h3c2 H3f3b Hdac2 Hdac1l Gata3 LOC684841 Hist1h2ail1 LOC102549173 Kif2a Kif2c Kif2b Hist1h3c Kif18a Hist1h3f Prkar2b LOC684819 Prkar2a Hist1h3a Capzb Kif5b Kif5a LOC684762 Cdc42 MRNA SPLICING%REACTOME DATABASE ID RELEASE 66%10144829 mRNA Splicing Cwc27 Cwc25 Cwc22 Snrpf Wdr33 Ppie RGD1565904 Isy1 Polr2g Polr2h Polr2e Snrnp25 Polr2f Zrsr1 Zcrb1 Polr2j Polr2k Zmat5 Polr2d Snrnp48 Polr2i Rnpc3 Polr2b Zrsr2 Polr2c Snrnp35 Polr2a Pdcd7 Xab2 LOC100912534 Prpf19 Srsf3 Ccar1 Cdc5l Upf3b U2af2 LOC102548514 Cd2bp2 Papola Srsf6 Elavl1 Srsf7 Ppil6 Prpf38a Srsf4 Srsf5 Srsf2 Hnrnph1 Ppih LOC100359574 Ppil1 Ppil3 Elavl2 Srsf9 Ppil4 Dhx38 LOC100911822 Fblim1 Clp1 Aqr Hnrnph2 Cwc15 Cherp Magoh Hnrpd Ncbp2 Srsf1 LOC100363335 Ctnnbl1 Ppwd1 LOC500684 Ncbp1 LOC680519 Dhx9 Ybx1 LOC100910750 Nhp2l1 Cstf2t Eif4a3 Sympk Bud31 Hnrnpul1 Txnl4a LOC100910660 Hnrnpk Srrm1 Hnrnpu Hnrnpr Wbp4 Usp39 Hnrnpl Snrpa Hnrnpm Hnrnpf Cdc40 Snrpc Hnrnpa2b1 Snrpb Rnps1 Dhx16 Dhx15 Sugp1 Prpf40a Sart1 Snrpb2 Magohb Phf5a Rbm8a Ddx23 Pcf11 Fip1l1 Hnrnpa0 U2surp Nudt21 Snrpd1 Eftud2 LOC100364748 Snrpd2 Snrpd3 Rbm5 Tra2b Sf3b2 Sf3b4 Sf3b3 Pqbp1 Sf3b5 Cstf2 Rbm22 Lsm8 Puf60 Wbp11 Lsm7 U2af1l4 Gtf2f1 Lsm6 Gtf2f2 Lsm4 Lsm3 Lsm5 Cpsf7 Cpsf2 Cpsf3 Cpsf4 Lsm2 Rbm17 Snw1 Cstf1 Snrnp200 Cpsf1 Smptb Gpkow Plrg1 LOC679753 Prpf6 Sf3a3 Sf3b1 Prpf8 Prpf4 Ddx5 Ddx46 Sf3a1 Prpf31 Ddx42 Bcas2 Prpf3 Sf3a2 Crnkl1 LOC100360750 Syf2 Fus Smndc1 Prcc Rbmx LOC100359916 Snrpa1 Snrnp70 FRUCTOSE CATABOLISM%REACTOME%R-RNO-70350.1 Fructose catabolism Aldob Khk Glyctk Tkfc METABOLISM OF FAT-SOLUBLE VITAMINS%REACTOME DATABASE ID RELEASE 66%10145778 Metabolism of fat-soluble vitamins Agrn Gpihbp1 Pnlip Akr1b7 Akr1b8 Apoa1 Sdc2 Sdc3 Sdc4 Clps Gpc6 Akr1c2 Gpc4 Gpc2 Rbp4 Akr1c12l1 Akr1c3 Ubiad1 Ttr Lrp1 Lrp10 Rbp2 Tex12 Rbp1 Lrp8 Ttpa Apom Lrp12 Lpl Akr1c19 Apob Bco1 Apoc2 Rdh11 Apoe Apoa2 Lrat Bco2 Gpc1 Akr1c13 Akr1c14 RGD1564865 Akr1c12 Akr1c1 NGF PROCESSING%REACTOME DATABASE ID RELEASE 66%10145269 NGF processing Ngf Pcsk6 Pcsk5 Furin BETA-CATENIN PHOSPHORYLATION CASCADE%REACTOME%R-RNO-196299.1 Beta-catenin phosphorylation cascade Peg12 Amer1 Csnk1a1 Frat2 Ppp2r5e Apc Ppp2r1b LOC100909468 Ppp2r5c Ppp2r5a Ppp2cb Ppp2ca Ppp2r5b Ppp2r1a SYNDECAN INTERACTIONS%REACTOME%R-RNO-3000170.1 Syndecan interactions Vtn Prkca Itgb4 Itga6 Sdc2 Tgfb1 Fgf2 Sdc3 Sdc4 MET RECEPTOR RECYCLING%REACTOME DATABASE ID RELEASE 66%10146253 MET receptor recycling Gga3 Gab1 Hgf Crk Crkl Rab4b Arf6 Rab4a Grb2 LOC100911248 IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX%REACTOME DATABASE ID RELEASE 66%10144904 Import of palmitoyl-CoA into the mitochondrial matrix Cpt1b Cpt2 Thrsp Cpt1a Ppard Mid1ip1 Rxra Slc25a20 Prkab2 Prkaa2 Slc22a5 COSTIMULATION BY THE CD28 FAMILY%REACTOME DATABASE ID RELEASE 66%10145355 Costimulation by the CD28 family Cd80 Cd86 Map3k8 Rac1 Cd4 Rictor Fyn Trib3 LOC100909468 Pak2 Pak3 Pak1 Them4 Akt2 Src Ppp2r5e Pik3r1 Pik3r3 Pik3r2 Pdcd1lg2 Tnfrsf14 Btla Akt1 Icoslg Cd28 Pdcd1 Cd274 LOC100911478 Cd3e Icos Ppp2r5c Ppp2cb Ppp2r5a RT1-Ba Ppp2ca RT1-Bb RT1-Da Ppp2r1a RT1-Db2 Ppp2r5b RT1-Db1 LOC688090 Vav1 Mtor Cd247 Csk Ppp2r1b Mlst8 Pdpk1 Mapkap1 Cdc42 Cd3g Akt3 Map3k14 Ptpn11 Cd3d Ptpn6 Lyn Yes1 Grb2 G1 S TRANSITION%REACTOME DATABASE ID RELEASE 66%10144724 G1 S Transition Psmc6 Psmb10 Psmb8 Pole2 Psmb9 Pole4 Psmb4 Psmb5 Psmf1 Psmb6 Psmd4 Mnat1 Psmb2 Psmd5 Psmd8 Psmd9 Psmb3 Psmd11 Psmd12 Prim2 Ccna2 Ccne2 Pola2 Ccna1 Psmd13 Prim1 Ccne1 Psmd14 Mcm2 Mcm4 Mcm3 Cdk2 Mcm5 Rpa3 Mcm6 Pole Mcm10 Psmc3 Ccnh Mcm8 Mcm7 Orc4 Orc5 Orc6 Orc1 Orc2 Orc3 Cdc7 Cdc6 Cdc45 Cdk4 Akt1 Rpa1 Ppp2cb Ccnd1 Ppp2ca Rpa2 Skp1 Ppp2r1a Skp2 Cdkn1a Cdkn1b Ppp2r1b Akt3 Ppp2r3b Cul1 Ptk6 Cks1l Cables1 Cks1b Akt2 Gmnn G6pc Rb1 Psmb7 Psmb1 Psma5 Cdk7 Cdt1 Psma2 Psmc5 Psma1 Psmd2 Psma4 Psmc1 Cdc25a Psma3 Wee1 Psmc4 Psma6 Psmc2 Psme1 Psmd1 Psme2 Psmd7 Psmd3 Psmd6 PHOSPHO-PLA2 PATHWAY%REACTOME DATABASE ID RELEASE 66%10144988 phospho-PLA2 pathway Pla2g4a Mapk1 NRAGE SIGNALS DEATH THROUGH JNK%REACTOME%R-RNO-193648.1 NRAGE signals death through JNK Arhgef6 Arhgef5 Arhgef39 Arhgef7 Arhgef37 Arhgef38 Arhgef33 Prex1 Itsn1 Arhgef2 Rac1 LOC102556447 Arhgef4 Arhgef3 Plekhg5 Arhgef19 Arhgef18 Plekhg2 Kalrn Bcl2l11 LOC100912512 Vav2 Gna13 Vav1 Arhgef11 Akap13 Arhgef16 Arhgef15 Bad Net1 Ect2 Arhgef26 Fgd2 Mapk8 Mcf2l Tiam1 Tiam2 Vav3 Fgd3 Sos2 Ngef Sos1 HDR THROUGH HOMOLOGOUS RECOMBINATION (HRR)%REACTOME%R-RNO-5685942.1 HDR through Homologous Recombination (HRR) Rhno1 Rfc1 Bard1 Rfc2 Wrn Topbp1 Rbbp8 Rmi1 Pole2 Rmi2 Pole4 Rad51c Polh LOC100911267 Spidr Rad51d Eme2 Rad51 Eme1 Brca2 Rtel1 Rad50 Atm Atrip Rpa3 Pole Pcna Xrcc3 Rad1 Brca1 Blm Atr Slx4 Mus81 Rad17 Slx1b Palb2 Gen1 Rfc5 Xrcc2 Rad9a Rfc4 Nbn Rfc3 Rad9b Mre11a Hus1 Rpa1 Rpa2 Pold2 Pold1 Pold4 Slc25a16 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE%REACTOME%R-RNO-532668.1 N-glycan trimming in the ER and Calnexin Calreticulin cycle Edem3 Calr Man1b1 Rnf139 Ganab Derl1 Edem2 Engase Uggt1 Trim13 Rad23b Mlec Rnf5 Ngly1 Prkcsh Vcp Ubxn1 Psmc1 Canx Rnf103 March6 Os9 Sel1l IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL%REACTOME%R-RNO-198933.1 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell PVR Cd40 Cd34 Siglec1 Mill1 LOC680910 LOC685157 Itgb7 Cd200 Hcst Madcam1 Cd300lb Itgb2 Cd300le Colec12 Kir3dl1 Pianp Itga4 Cd300e Cd300lg Cd1d1 Cd300lf Crtam LOC685048 RGD1559588 Sh2d1b2 RT1-A Pilra Cd22 RGD1566006 LOC685438 Trem1 Ifitm3 Cd40lg Cd226 LOC100911324 RT1-A2 Pvrl2 RT1-M3-1 Ifitm2 RT1-A1 Ifitm1 Sh2d1a Sh2d1b Cd8b B2m Cd19 Cd8a RGD1561143 Slamf7 Cd81 Siglec10 Slamf6 RGD1561778 Npdc1 Treml2 RT1-M2 LOC100364500 Cd200r1 RT1-M5 Cd200r1l RT1-M4 LOC681182 Cd96 RT1-S3 Itgal Icam4 RT1-CE2 Icam5 RT1-CE3 RT1-CE4 RT1-CE7 RT1-CE5 Icam1 Vcam1 RT1-CE10 Trem2 Cd3e Cd247 RGD1559482 C3 RT1-M6-1 Lair1 LOC683761 LOC100364956 Cd3g RT1-M6-2 Cd3d Icam2 GAMMA-CARBOXYLATION, TRANSPORT, AND AMINO-TERMINAL CLEAVAGE OF PROTEINS%REACTOME DATABASE ID RELEASE 66%10145094 Gamma-carboxylation, transport, and amino-terminal cleavage of proteins Ggcx Pros1 Proz Bglap F2 F7 F9 Gas6 Furin NOTCH4 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME DATABASE ID RELEASE 66%10146329 NOTCH4 Activation and Transmission of Signal to the Nucleus Ywhaz Notch4 PHOSPHATE BOND HYDROLYSIS BY NUDT PROTEINS%REACTOME DATABASE ID RELEASE 66%10145964 Phosphate bond hydrolysis by NUDT proteins Adprm Nudt9 Nudt5 Nudt16 Nudt18 LOC688828 Nudt15 Nudt1 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS%REACTOME DATABASE ID RELEASE 66%10145963 Non-integrin membrane-ECM interactions Fgf2 Ttr Ddr1 Pdgfa Pdgfb Prkca Vtn Itgb4 Itga6 Sdc2 Sdc3 Tgfb1 Sdc4 MITOTIC METAPHASE ANAPHASE TRANSITION%REACTOME DATABASE ID RELEASE 66%10145108 Mitotic Metaphase Anaphase Transition Fbxo5 CILIUM ASSEMBLY%REACTOME DATABASE ID RELEASE 66%10146080 Cilium Assembly Kif3c Kif3b Kifap3 Arf4 Dync1i2 Nphp1 Cep57 Cep97 Rab8a B9d1 Cep162 LOC691918 Gbf1 Haus3 Ninl Akap9 Nphp4 Ccp110 Tmem216 Rpgrip1l Pafah1b1 Smo Wdr35 Kif3a Ift88 Dynll2 Cngb1 Inpp5e Tubb5 Ywhag Ppp2r1a Exoc3 Exoc2 Exoc1 Exoc6 Ywhae Exoc5 Exoc8 Exoc7 Nek2l1 Prkaca Nek2 Hdac6 Dync1h1 Ttc8 Bbs9 Bbs1 LOC103692716 Bbs2 Mchr1 Arl6 Rab3ip Lztfl1 Trip11 Mks1 Dctn1 C2cd3 Cntrl Ift81 Dctn2 Cep76 Sept2 Pcm1 Cep78 LOC100912537 Ttbk2 Mark4 B9d2 LOC100911033 Cep164 Dctn3 Ofd1 Cep41 Sclt1 Sstr3 Tctn1 Sdccag8 Bbs7 Bbs5 Bbs4 Cep83 Prkar2b Cenpj Cep89 Plk4 Ift122 Wdr19 Ttc21b Ahi1 LOC100912076 Tubg2 Haus2 Haus1 Ift46 Ift43 Haus5 Alms1 Wdr60 Clasp1 Kif17 Haus4 Tnpo1 Odf2 Pde6d Tubb4a Cdk1 Iqcb1 Dynlrb2 Rab11a Ift74 Tmem67 Ttc26 Ssna1 Dynlrb1 Tubg1 Mapre1 Tcte3 Cep63 Dync2li1 Csnk1d Atat1 Cep131 Ift52 Pkd2 Tuba4a Pkd1 Cep250 Hspb11 Cnga4 Cep135 Ift57 Cnga2 Csnk1e Traf3ip1 Cdk5rap2 Ckap5 Ift27 Kif24 Arl13b Pcnt Ift22 Cep72 Ift20 Sfi1 Cluap1 Cep70 Tctex1d1 Actr1a Tctex1d2 LOC100911746 Ift140 Ttc30b Nedd1 Ift80 Fbf1 BETA OXIDATION OF MYRISTOYL-COA TO LAUROYL-COA%REACTOME%R-RNO-77285.1 Beta oxidation of myristoyl-CoA to lauroyl-CoA Acadl Hadha Hadhb CELLULAR HEXOSE TRANSPORT%REACTOME%R-RNO-189200.1 Cellular hexose transport Slc2a9 Slc45a3 Slc2a6 Slc2a4 Fgf21 Slc5a10 Slc50a1 Slc5a1 Slc5a4 Slc5a2 RGD1559971 Slc2a8 Slc2a1 Slc2a2 RGD1561777 Slc5a9 Slc2a12 Slc2a10 RGD1304770 CARGO CONCENTRATION IN THE ER%REACTOME DATABASE ID RELEASE 66%10146150 Cargo concentration in the ER Areg Ctsc Stx5 Tmed2 Sec24a Sec24b Cnih1 Sec24d Ctsz Ctage5 Mcfd2 Preb Cnih3 Cnih2 Cd59 Tgfa Sec22b Sec23a Lman1l Sar1b Col7a1 F8 Lman2 Sec24c Gosr2 Folr1 Lman1 Tmed10 BIOSYNTHESIS OF SPECIALIZED PRORESOLVING MEDIATORS (SPMS)%REACTOME%R-RNO-9018678.1 Biosynthesis of specialized proresolving mediators (SPMs) Cyp2d5 Alox5 Lta4h Alox5ap Hpgd LOC100361547 Gpx4 Cyp3a23/3a1 Cyp3a73 Cyp2c7 Alox12 Cyp2e1 Ltc4s Gstm4 Cyp2d4 Cyp3a18 Cyp1a1 LOC100910877 Cyp2d2 Ptgs2 Ephx2 Cyp1a2 Alox15 Cyp2d3 Cyp2c6v1 DOWNSTREAM SIGNALING OF ACTIVATED FGFR3%REACTOME%R-RNO-5654708.1 Downstream signaling of activated FGFR3 Kras Pik3r1 Frs3 Fgf23 Fgf22 Fgf4 Fgf1 Fgf3 Fgf6 Fgf5 Fgf20 Gab1 Fgf16 Fgf17 Fgf10 Fgf9 Fgfr2 Fgf7 Fgf2 Fgf8 Fgfr3 Fgfr1 Fgfr4 Ptpn11 Plcg1 Fgf19 Hras Nras Frs2 Sos1 Shc1 Grb2 BIOSYNTHESIS OF DHA-DERIVED SULFIDO CONJUGATES%REACTOME%R-RNO-9026395.1 Biosynthesis of DHA-derived sulfido conjugates Ltc4s Gstm4 LOCALIZATION OF THE PINCH-ILK-PARVIN COMPLEX TO FOCAL ADHESIONS%REACTOME%R-RNO-446343.1 Localization of the PINCH-ILK-PARVIN complex to focal adhesions Ilk ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT)%REACTOME%R-RNO-917729.1 Endosomal Sorting Complex Required For Transport (ESCRT) Ubap1 Vps4b Chmp2b Chmp2a Mvb12b Vps25 Mvb12a Chmp5 Chmp7 Snf8 Vps36 Chmp4b Chmp6 Chmp3 Chmp4c Chmp4bl1 LOC100910929 Tsg101 Vta1 Vps37a Stam2 Vps37d Vps37c Vps37b Stam MAPK3 (ERK1) ACTIVATION%REACTOME%R-RNO-110056.1 MAPK3 (ERK1) activation Ptpn11 Il6st Jak1 Il6 Cdk1 Tyk2 PEPTIDE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145486 Peptide ligand-binding receptors Npff Npffr2 RGD1560028 Hcrt Psap Npffr1 Qrfp LOC100909783 Kng1l1 F2rl3 Hcrtr1 F2r Qrfpr Cxcr2 F2 Hcrtr2 F2rl2 Hebp1 Uts2 Ntsr2 Fpr-rs6 Ccr6 Trhr Nmu Pf4 Fpr-rs3 Mc5r Fpr2 Fpr3 Pomc Ntsr1 Anxa1 Pmch Rxfp1 Rxfp2 Kel Insl3 Fpr-rs4 Tac3 Kiss1 Rxfp3 Tac1 Edn2 Ednra Ednrb Edn3 Grp Grpr Cx3cr1 Edn1 F2rl1 Sst Oxtr Ackr4 Ackr3 Oxt LOC100909648 Nmb Avpr1b Xcl1 Cxcl9 Avpr1a Cxcl6 Cx3cl1 Cxcl2 Cxcl1 Agt Cxcl3 Agtr2 Prlh Galr1 Ccrl2 Nts Oprk1 Oprl1 Agtr1b Ccl21 Agtr1a Prokr2 Mc3r Ccr5 Fpr1 Gal Ccr4 Ccr3 Gpr37 Ccl27 Cckar Gper1 Ccl20 Uts2r Prokr1 Ccl25 NMS Xcr1 Cxcl16 Pdyn Prlhr Ccr10 Gpr37l1 Ccl19 Ccr7 Ccr8 Cxcr3 Cxcl10 Ccr9 Cxcl11 Avp Ece2 Ece1 Xk Sstr5 Brs3 Npbwr1 C5ar2 Pyy Pnoc Ccl5 Npy2r Mc4r Prok2 Oprm1 Prok1 Mchr1 Sstr1 Aplnr Sstr4 Sstr2 Cck Npy1r Apln Tacr3 Tacr2 Bdkrb1 Bdkrb2 Rln3 Npb Ppy Trh Ccl1 Npw Mc2r Npy Nps C3ar1 Cxcl12 Sstr3 Penk C5ar1 Kng1 Cxcr4 Kng2 C3 Ppbp Cckbr Cxcr5 Uts2b Npy5r Nmur2 Cxcr6 Oprd1 Tacr1 BIOSYNTHESIS OF EPA-DERIVED SPMS%REACTOME%R-RNO-9018679.1 Biosynthesis of EPA-derived SPMs Hpgd Gpx4 Alox5 Ptgs2 Alox15 Lta4h HORMONE LIGAND-BINDING RECEPTORS%REACTOME%R-RNO-375281.1 Hormone ligand-binding receptors Gphb5 Gnrhr Gpha2 Gnrh1 Fshb Fshr Tshr Lhb Lhcgr LOC100909513 Tshb LOC100360745 Cga BIOSYNTHESIS OF DPA-DERIVED SPMS%REACTOME%R-RNO-9018683.1 Biosynthesis of DPA-derived SPMs Alox12 Alox5 Ptgs2 Alox15 SIGNALING BY PTK6%REACTOME%R-RNO-8848021.1 Signaling by PTK6 Ereg Nrg1 Kras Btc LOC100909609 LOC102552659 Erbb3 Erbb2 Pxn Srms Nrg3 Ptpn1 Stat3 Egfr Hbegf Cdk4 Akt1 Rac1 Arhgap35 Ptk6 Nrg4 Socs3 Ccnd1 Dok1 Ccne1 Cdk2 Arap1 Crk Cdkn1b Lrrk2 Bcar1 Stap2 Cbl Khdrbs2 Hif1a Gpnmb Khdrbs1 Khdrbs3 Rhoa Dock1 Erbb4 Hras Nras Elmo2 Rasa1 Nrg2 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%R-RNO-975144.1 IRAK1 recruits IKK complex upon TLR7 8 or 9 stimulation LOC100362142 Ube2n LOC100912618 Peli3 Ube2v1 Chuk Ikbkb Peli2 Traf6 Peli1 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS%REACTOME%R-RNO-390471.1 Association of TriC CCT with target proteins during biosynthesis Cct6b Cct8 Cct6a Tcp1 Cct7 Cct2 Cct4 Cct3 NCAM SIGNALING FOR NEURITE OUT-GROWTH%REACTOME DATABASE ID RELEASE 66%10145367 NCAM signaling for neurite out-growth Kras Fyn Ptpra Col9a1 Col9a2 Col9a3 Ncam1 Col4a1 Sptbn1 Sptan1 LOC501189 St8sia4 Mapk1 Spta1 Col4a2 Rps6ka5 Creb1 Hras Nras Ptk2 Sos1 Grb2 DOWNSTREAM SIGNAL TRANSDUCTION%REACTOME%R-RNO-186763.1 Downstream signal transduction Stat5a Src Kras Grb7 Stat1 Pik3r1 Pdgfra Pik3r2 Pdgfrb Stat3 Nck1 Pdgfa Pdgfb Stat6 Crk Bcar1 Pik3cb Ptpn11 Plcg1 Hras Crkl Nras Sos1 Rasa1 Rapgef1 Nck2 LOC100911248 Grb2 HDR THROUGH HOMOLOGOUS RECOMBINATION (HRR) OR SINGLE STRAND ANNEALING (SSA)%REACTOME%R-RNO-5693567.1 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) Rfc1 Rhno1 Rfc2 Bard1 Wrn Topbp1 Rbbp8 Rmi1 Pole2 Rmi2 Rad51c Pole4 Polh LOC100911267 Spidr Rad51d Eme2 Rad51 Brca2 Eme1 Rtel1 Rad50 Ppp4r2 Ppp4c Ccna2 Ccna1 Atm Atrip LOC100909750 Cdk2 Rpa3 Pole Pcna Xrcc3 Brca1 Rad1 Blm Atr Slx4 Mus81 Rad17 Slx1b Palb2 Sirt6 Gen1 Rfc5 Xrcc2 Rfc4 Rad9a Nbn Rfc3 Abl1 Rad9b Mre11a Hus1 Rad52 Rpa1 Rpa2 Ercc1 Pold2 Pold1 Pold4 Slc25a16 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE%REACTOME DATABASE ID RELEASE 66%10145601 Nitric oxide stimulates guanylate cyclase Pde1b Pde9a Pde3b Pde5a Pde3a LOC497963 Nos3 Itpr1 Prkg2 Pde2a Cyct Mrvi1 Pde10a Nos1 Pde11a ER QUALITY CONTROL COMPARTMENT (ERQC)%REACTOME DATABASE ID RELEASE 66%10145712 ER Quality Control Compartment (ERQC) Edem3 Man1b1 Rnf139 Rnf103 Edem2 March6 Uggt1 Trim13 Os9 Rnf5 Sel1l TRAFFICKING OF AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145593 Trafficking of AMPA receptors Ap2a2 Camk2g Mdm2 Dlg1 Gria3 Gria4 Grip1 Grip2 Camk2d Pick1 Camk2a Cacng8 Akap5 Prkca Prkcb Nsf Ap2s1 Cacng2 Cacng3 Cacng4 Ap2a1 Myo6 Dlg4 Ap2m1 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE%REACTOME%R-RNO-210500.1 Glutamate Neurotransmitter Release Cycle Slc1a3 Slc38a2 Slc1a7 Rab3a Slc1a6 Slc17a7 Slc1a1 Rims1 Cplx1 Stx1a Syt1 Vamp2 Stxbp1 Ppfia1 Ppfia2 Ppfia3 Ppfia4 Bzrap1 RAP1 SIGNALLING%REACTOME DATABASE ID RELEASE 66%10145480 Rap1 signalling Prkaca Prkacb Rapgef4 Rasgrp1 Rasgrp2 Raf1 Rap1a Ywhaz Rap1gap Ywhab Rap1gap2 Sipa1 MISMATCH REPAIR (MMR) DIRECTED BY MSH2:MSH6 (MUTSALPHA)%REACTOME DATABASE ID RELEASE 66%10146059 Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Msh2 Rpa3 LOC100911727 Pold2 Pold1 Pcna Pold4 Rpa1 Rpa2 Pms2 Mlh1 Msh6 Lig1 INTERLEUKIN-36 PATHWAY%REACTOME%R-RNO-9014826.1 Interleukin-36 pathway Il1rl2 Il36rn Il1f10 Il1rap Il36b Il36a SYNTHESIS OF PG%REACTOME%R-RNO-1483148.1 Synthesis of PG Cds2 SYNTHESIS OF PI%REACTOME%R-RNO-1483226.1 Synthesis of PI Cds1 Cdipt Pitpnm1 Pitpnm3 Pitpnm2 SYNTHESIS OF ACTIVE UBIQUITIN: ROLES OF E1 AND E2 ENZYMES%REACTOME DATABASE ID RELEASE 66%10146214 Synthesis of active ubiquitin: roles of E1 and E2 enzymes Ube2g2 LOC100911393 Ube2g1 Ube2q2 Usp7 Ube2r2 Ube2c Usp9x Ube2d1 Ube2k Ube2z Ube2h Uba6 Ube2a Ube2t Ube2s Uchl3 RGD1561252 Usp5 Cdc34 Ube2e3 Otulin LOC100911959 Uba1 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE%REACTOME%R-RNO-442720.1 CREB phosphorylation through the activation of Adenylate Cyclase Adcy8 Adcy3 TNFR1-INDUCED NFKAPPAB SIGNALING PATHWAY%REACTOME DATABASE ID RELEASE 66%10146055 TNFR1-induced NFkappaB signaling pathway Rnf31 Sharpin Usp2 Traf1 Rbck1 Usp21 Birc3 Birc2 Otud7b Cyld Chuk Traf2 Usp4 LOC100910771 Tab2 Tab3 Tab1 Ripk1 Ikbkb Tnf Tradd Xiap Map3k7 Tnfaip3 BIOSYNTHESIS OF MARESIN-LIKE SPMS%REACTOME DATABASE ID RELEASE 66%10146318 Biosynthesis of maresin-like SPMs LOC100361547 Cyp3a23/3a1 Cyp3a73 Cyp2d5 Cyp2c7 Cyp2e1 Cyp2d4 Cyp3a18 LOC100910877 Cyp2d2 Cyp1a2 Cyp2d3 Cyp2c6v1 CONJUGATION OF BENZOATE WITH GLYCINE%REACTOME%R-RNO-177135.1 Conjugation of benzoate with glycine Glyatl3 Acsm1 Glyat ABC-FAMILY PROTEINS MEDIATED TRANSPORT%REACTOME DATABASE ID RELEASE 66%10145462 ABC-family proteins mediated transport Psmc6 Eif2s3 Psmb10 Psmb8 Psmb9 Psmb4 Psmb11 Psmb5 Psmf1 Abcd1 Psmb6 Psmd4 Psmb2 Vcp LOC688708 Psmd5 Psmd8 Psmd9 Psmb3 Psma8 Psmd11 Psmd12 Eif2s1 Eif2s2 Psmd13 Psmd14 Derl1 Psmc3 Kcnj11 Abcc9 G6pc Psmb7 Psmb1 Apoa1 Os9 Erlec1 Abcd2 Abcc4 Abcc2 Abcc6 Psma5 Abcd3 Abcb8 Abcb9 Derl3 Erlin2 Abcb10 Rnf5 Pex3 Abcb5 Psma2 Abcb6 Psmc5 Abca4 Psma1 Psmd2 Abca3 Psma4 Abcf1 Psmc1 Abca2 Psma3 Abcc10 Psmc4 Erlin1 Psma6 Psmc2 Abca6 Psme1 Abca5 Abcg4 Abcg1 Psmd1 Psme2 Psmd7 Abcb1a Abca7 Sel1l Abcg8 Psmd3 Abcg5 Psmd6 TRANSPORT OF GLYCEROL FROM ADIPOCYTES TO THE LIVER BY AQUAPORINS%REACTOME DATABASE ID RELEASE 66%10145643 Transport of glycerol from adipocytes to the liver by Aquaporins Aqp7 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE%REACTOME%R-RNO-606279.1 Deposition of new CENPA-containing nucleosomes at the centromere Cenpn LOC100910200 Cenpl H2afx Cenpo Hist1h4b Mis18bp1 Hist1h2bh Cenpt Cenpu LOC100912290 Rbbp7 Hist1h4m LOC103690002 LOC100910152 LOC100912338 H2afb3 Cenpk Hist2h4 Cenph Cenpi Hjurp H2afj Hist2h2aa3 Hist1h2bq Hist2h2aa2 Cenpm Casc5 LOC100364835 Hist1h2bo Hist1h2bcl1 Hist1h2bk Cenpc Cenpa Cenpw Hist1h2bg Ruvbl1 LOC100911204 Smarca5 LOC680097 LOC684797 LOC100912418 Hist1h2ba Hist3h2bb Itgb3bp INTERCONVERSION OF 2-OXOGLUTARATE AND 2-HYDROXYGLUTARATE%REACTOME%R-RNO-880009.1 Interconversion of 2-oxoglutarate and 2-hydroxyglutarate D2hgdh Adhfe1 L2hgdh HS-GAG DEGRADATION%REACTOME%R-RNO-2024096.1 HS-GAG degradation Gpc6 Agrn Gpc4 Gpc2 Glb1l Glb1 Gusb Hpse Sdc2 Sdc3 Gpc1 Naglu Sdc4 Idua GABA B RECEPTOR ACTIVATION%REACTOME%R-RNO-977444.1 GABA B receptor activation Kcnj4 Kcnj6 Gnai3 Gnal Gnat3 Adcy3 Adcy8 Adcy9 Adcy5 Gnai2 Adcy4 Adcy7 Adcy6 Gnb3 Kcnj16 Gnb2 Gnb1 Gng12 Kcnj2 Kcnj3 Kcnj15 Kcnj9 Kcnj5 Gng4 Gngt2 Gnai1 Gng5 Gabbr1 Gngt1 Kcnj12 Gng10 Gng8 Gabbr2 Gng3 GLYCEROPHOSPHOLIPID CATABOLISM%REACTOME DATABASE ID RELEASE 66%10146195 Glycerophospholipid catabolism Enpp6 Pnpla6 PI3K AKT SIGNALING%REACTOME%R-RNO-1257604.1 PI3K AKT Signaling Ereg Nrg1 Trim27 Btc Usp7 LOC102552659 Mdm2 Erbb3 Erbb2 Nrg3 Egfr Hbegf Esr2 Nrg4 Csnk2a2 Nr4a1 Csnk2a1 Pml Fyn Il1rap Nrg2 Pik3ap1 Il1rl1 Akt1 Hdac1 Phlpp1 Ier3 Pdgfa Rps6kb2 Pdgfb Foxo1 Foxo3 Pik3cd Stub1 Irak4 Cdkn1a Cdkn1b Traf6 Il33 Pip5k1c Pip5k1b Pip5k1a Cd19 LOC100909468 Hgf Rac2 Ppp2r5e G6pc Pdgfra Pdgfrb Frk Psmb7 Psmb1 Ppp2r5c Ppp2r5a Ppp2r5b Vav1 Foxo4 Psma5 Pdpk1 Psma2 Psmd2 Psmc2 Psmd1 Psmd7 Kit Kitlg Psmd3 Psmd6 Psmc6 Pten Psmb10 Psmb8 Psmb9 Psmb4 Psmb11 Psmb5 Psmf1 Psmb6 Rac1 Psmd4 Psmb2 Psmd5 Psmd8 Psmd9 Psmb3 Psma8 Psmd11 Psmd12 Psmd13 Psmd14 RragB Rictor Fgf2 Psmc3 Pip4k2b Pip4k2c Src Pik3r3 Akt1s1 Ppp2cb Ppp2ca Ppp2r1a Xiap Tnks Phc1 Phc2 Mtor Rheb Rptor Lamtor4 Chuk Lamtor5 Ppp2r1b Mlst8 Tsc2 Rraga Mapk1 Rragc Akt3 Rragd Slc38a9 Creb1 Myd88 Cd80 Cd86 Otud3 Fgf23 Fgf22 Fgf4 Fgf1 Fgf3 Fgf6 Fgf5 Lamtor3 Fgf20 Gab1 Sall4 Scmh1 Cbx4 Cbx2 Cbx8 Fgf16 Lamtor2 Cbx6 Fgf17 Lamtor1 Bmi1 Irs2 Hdac2 Fgf10 Fgf9 Rnf2 Fgfr2 Mbd3 Fgf7 Usp13 Fgf8 Ring1 Hdac1l Fgfr3 Chd3 Trib3 Chd4 Phc3 Fgfr1 Prex2 Fgfr4 Esr1 Insr Ins1 Ins2 Mta3 Fgf19 Erbb4 Tnks2 Them4 Irs1 Mta1 Frs2 Mta2 Gatad2a LOC100910717 Maf1 Gatad2b Akt2 Eed Pik3r1 Pik3r2 Rbbp7 Mecom Cd28 Icos Casp9 Csnk2b Mapkap1 Psmc5 Pik3cb Psma1 Psma4 Psmc1 Ptpn11 Psma3 Psmc4 Psma6 Psme1 Ezh2 Psme2 Rhog Grb2 SUMOYLATION OF TRANSCRIPTION FACTORS%REACTOME%R-RNO-3232118.1 SUMOylation of transcription factors Mitf Sumo1 Pias3 Pias4 Ube2i Tfap2c Pias1 Mta1 Tp53bp1 Foxl2 Sumo3 Pias2 M PHASE%REACTOME%R-RNO-68886.1 M Phase Cenpn Zwilch Cenpl Cenpo Dync1li2 Cenpt Cenpu Kif23 Bub3 Bub1 Spdl1 Kntc1 Dync1i2 Mad1l1 LOC100910252 Csnk2a2 Stag1 Cenpk Cenph Cenpi Csnk2a1 Pds5b Pds5a Cenpf Cdca5 Cenpe Rad21 Cenpm Smc1a Stag2 Ahctf1 Smc3 Ndel1 Rcc2 Pafah1b1 Mis12 LOC102555167 Dynll2 Ndc80 Cenpc Cenpa Dync1i1 Birc5 Taok1 Ube2d1 Nup88 RGD1310212 Nup85 Anapc7 Cdc26 Cdc27 Cdc23 Pttg1 Ube2c Anapc16 Cdc16 Nek2l1 Rae1 Anapc4 Anapc2 Anapc1 Kif20a Lpin2 Prkca Lpin3 Lpin1 Nek2 Nup93 Nup98 Rab2a Nup107 Nup210 Anapc11 Nupl2 Anapc15 Anapc10 Nupl1 Fbxo5 Cdca8 Rangap1 Ppp1cc LOC100909468 Aurkb Sec13 Ensa Xpo1 Arpp19 Rab1b Nup205 Rab1a LOC100911204 Spc24 Spc25 Itgb3bp Sgol2 Ppp2r5e Incenp G6pc Nsl1 Nup155 B9d2 Cdc20 Kif2a Kif2c Kif2b Psmb7 Psmb1 Bub1b Kif18a Ppp2r5c Ppp2r5a Ppp2r5b Zwint Dsn1 Mad2l1 Casc5 Nup153 Clasp2 Ercc6l Nuf2 Psma5 Clasp1 Tpr LOC679582 Mapre1 Psma2 Cdc42 Pmf1 Psmd2 Nup54 Psmc2 Ckap5 Pom121 Ska2 Psmd1 Psmd7 Nup62 Sgol1 Zw10 Psmd3 Ska1 Psmd6 Psmc6 Nup43 Psmb10 Nup133 Psmb8 Psmb9 Psmb4 Aaas Psmb11 Psmb5 Psmf1 Psmb6 Psmd4 Psmb2 Psmd5 Npap60 Psmd8 Cep57 Psmd9 Psmb3 Nup35 Psma8 Nup37 Psmd11 LOC691918 Psmd12 Haus3 Psmd13 Ninl Psmd14 Akap9 Ccp110 Psmc3 Ranbp2 Setd8 Tubb5 Ppp2cb Ppp2ca Ywhag Ppp2r1a Prkcb Ywhae Ppp2r1b Mapk1 Prkaca Tubgcp2 Hist1h2bo Dync1h1 Hist1h2bcl1 Cnep1r1 Hist2h3c2 Hist1h2bk Gorasp2 H3f3b Dync1li1 LOC103692716 Numa1 Lemd2 Nek6 Blzf1 Hdac8 Nek7 LOC100909949 Dctn1 LOC100910200 Cntrl H2afx Mcph1 Dctn2 RGD1563307 Hist1h4b Cep76 LOC684841 Hist1h2bh Pcm1 Rb1 Cep78 Ncapg LOC100912290 Hist1h2ail1 Gorasp1 Lemd3 LOC100911033 Hist1h4m LOC102549173 Cep164 Mau2 LOC103690002 Dctn3 Cep41 Ofd1 Lmna LOC100910152 LOC100912338 Vrk2 Hist1h3c Sdccag8 Ncaph2 H2afb3 Hist1h3f Vrk1 Ctdnep1 Prkar2b Cenpj Hist2h4 LOC684819 Hist1h3a Plk4 Smc4 H2afj Hist2h2aa3 Tmpo Hist1h2bq Espl1 Hist2h2aa2 Smc2 LOC100364835 LOC684762 LOC100912076 Tubg2 Csnk2b Haus2 Haus1 Haus5 Alms1 Haus4 Odf2 Tubb4a Cdk1 Lmnb1 Ncapg2 Ssna1 Tubg1 Cep63 Csnk1d Psmc5 Cep131 Psma1 Tuba4a Psma4 Cep250 Psmc1 Cep135 Psma3 Csnk1e Psmc4 Cdk5rap2 Psma6 Psme1 Nme7 Tubgcp5 Hist1h2bg Pcnt Tubgcp6 Psme2 Cep72 Tubgcp3 LOC680097 Sfi1 Tubgcp4 LOC684797 Cep70 Actr1a LOC100912418 Hist1h2ba LOC100363782 Mzt1 Hist3h2bb Nedd1 Mzt2b ACTIVATION OF BID AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%R-RNO-75108.1 Activation of BID and translocation to mitochondria Gzmbl1 Gzmc LOC100911163 Gzmbl2 Gzmbl3 Nmt1 Bid Gzmb Casp8 LOC691695 FGFR1C AND KLOTHO LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 66%10145295 FGFR1c and Klotho ligand binding and activation Fgf23 Fgfr1 INTRAFLAGELLAR TRANSPORT%REACTOME%R-RNO-5620924.1 Intraflagellar transport Kif3c Ift81 Kif3b Kifap3 Ift122 Wdr19 Ttc21b Ift46 Ift43 Wdr60 Kif17 Tnpo1 Dynlrb2 Ift74 Ttc26 Wdr35 Dynlrb1 Kif3a Tcte3 Ift88 Dync2li1 Dynll2 Ift52 Hspb11 Ift57 Traf3ip1 Ift27 Ift22 Trip11 Ift20 Cluap1 Tctex1d1 Ift140 Tctex1d2 Ttc30b Ift80 BETA OXIDATION OF PALMITOYL-COA TO MYRISTOYL-COA%REACTOME DATABASE ID RELEASE 66%10144934 Beta oxidation of palmitoyl-CoA to myristoyl-CoA Hadha Hadhb Acadvl SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE%REACTOME DATABASE ID RELEASE 66%10145902 Synthesis of PIPs at the early endosome membrane Pi4k2a Pik3c3 Mtmr2 Fig4 Pik3r4 Inpp4a Mtmr4 Inpp4b Vac14 Mtmr12 Inpp5f Pikfyve Pik3c2a Pi4k2b RNA POLYMERASE II TRANSCRIPTION ELONGATION%REACTOME%R-RNO-75955.1 RNA Polymerase II Transcription Elongation Gtf2h1 Gtf2h2 Mnat1 RGD1565904 Leo1 Polr2g Polr2h Polr2e Polr2f Supt16h Polr2j Polr2k Polr2d Ctr9 Polr2i Polr2b Polr2c Polr2a Wdr61 Gtf2f1 LOC100912534 Gtf2f2 Ell Tceb2 Tceb1 Iws1 Tcea1 Ccnh Gtf2h3 Paf1 Gtf2h5 Gtf2h4 Cdc73 Aff4 Ccnt2 Tceb3 Rtf1 Cdk9 Supt6h Eaf1 Eaf2 Ercc3 Ccnk Supt5h LOC100911822 Mllt1 Ercc2 Ncbp2 Ncbp1 Supt4h1 Cdk7 Nelfe Nelfa Nelfb Ssrp1 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE%REACTOME DATABASE ID RELEASE 66%10145157 Toll Like Receptor 5 (TLR5) Cascade Map2k7 Ripk2 Map2k6 Ager Dusp3 Map2k4 Map3k8 Dusp4 Peli3 Nfkbib LOC100912399 Peli2 Map3k1 Traf6 Cul1 Vrk3 Rps6ka2 Rps6ka1 App Rps6ka3 Rps6ka5 LOC100912585 Tab1 Dusp7 Dusp6 Rela Atf1 Atf2 Map3k7 Peli1 Irak2 Nfkbia LOC100910771 Ube2n Jun Ppp2cb Ppp2ca Skp1 Ppp2r1a Nfkb2 Nfkb1 Mapk9 Mapk8 Fos S100b Mapk7 Dhx9 Fbxw11 Chuk Ppp2r1b Ecsit Mapkapk3 Btrc Mapkapk2 Mapk1 Nkiras1 LOC100362142 Nod1 Nod2 Nkiras2 Creb1 Tab2 Tab3 LOC100912618 Ube2v1 Ikbkb Mapk14 Myd88 Tnip2 Mapk11 Mapk10 GLUCOCORTICOID BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 66%10145323 Glucocorticoid biosynthesis Pomc Hsd3b1 Hsd3b Hsd3b2 LOC100911154 Hsd11b2 Cyp21a1 Cyp11b2 REACTIONS SPECIFIC TO THE COMPLEX N-GLYCAN SYNTHESIS PATHWAY%REACTOME DATABASE ID RELEASE 66%10145779 Reactions specific to the complex N-glycan synthesis pathway Mgat2 Chst8 Lhb Man2a1 Fut8 Man2a2 Chst10 Cga SIGNALING BY INTERLEUKINS%REACTOME DATABASE ID RELEASE 66%10145163 Signaling by Interleukins Il21r Il21 Rbx1 Socs5 Socs3 Vamp2 Casp3 Fyn Stat6 Il1rl2 Il36rn Il1f10 Il1rap Il36b Il36a Sqstm1 Stx4 Ube2n Ptk2b Il1rl1 Brwd1 Pik3cd Irak4 Crk Stx1a Lyn Crkl Yes1 Hck Rapgef1 Syk LOC100911248 Map2k7 Ripk2 Tbk1 Map2k6 Ager Dusp3 Map2k4 Map3k8 Dusp4 Peli3 Nfkbib Peli2 Traf6 Cul1 Vrk3 Rps6ka2 Rps6ka1 App Rps6ka3 Il33 Canx Rps6ka5 LOC100912585 Tab1 Dusp7 Dusp6 Rela Atf1 Atf2 Map3k7 Peli1 Irak2 Nfkbia LOC100910771 Il2rg G6pc Psmb7 Psmb1 Vav1 Il9r Il15 Il9 P4hb Psma5 Tollip Sos2 Psma2 Il10ra Il10 Il5 Psmd2 Il2 Ptpn6 Psmc2 Il2ra Csf2 Psmd1 Il3ra Psmd7 Psmd3 Il2rb Psmd6 Psmc6 Csf2ra Csf2rb Psmb10 Psmb8 Psmb9 Psmb4 Psmb11 Psmb5 Psmf1 Il5ra Psmb6 Psmd4 Psmb2 Psmd5 Psmd8 Psmd9 Psmb3 Psma8 Psmd11 Psmd12 Psmd13 Psmd14 Csf1 Psmc3 Il1b Pik3r3 Inpp5d Jun Ppp2cb Ppp2ca Skp1 Ppp2r1a Ywhaz Nfkb2 Nfkb1 Mapk9 Mapk8 Fos S100b Mapk7 Dhx9 Fbxw11 Chuk Ppp2r1b Mapkapk3 Btrc Mapkapk2 Mapk1 Nkiras1 Prkaca LOC100362142 Nod1 Nod2 Nkiras2 Creb1 Tab2 Tab3 LOC100912618 Ube2v1 Ikbkb Mapk14 Myd88 Tnip2 Mapk11 Mapk10 Stat5a Jak3 Il22 Il24 Il19 Stat1 Il22ra1 Jak1 Stat2 Stat3 Il10rb Hsp90b1 Cd4 Hist2h3c2 Irs2 Cbl Smarca4 Il13ra1 Clcf1 Il13ra2 Il12b Il31ra Irak3 Il12a LOC100360218 Il22ra2 Cntf Il20ra Irs1 Csf3 Il20rb Il23r Il1r1 Tyk2 Ifnl3 Crlf2 Il20 Ebi3 Ifnlr1 Il4r Il17c Il1rapl1 Map3k3 Il17a Il23a Crlf1 LOC684841 Il4 Pik3r1 Il6 Lif Il6st Pik3r2 Stxbp2 Csf1r Ptprz1 Hist1h2ail1 Il13 Txlna LOC102549173 Il11ra1 Lifr Il18r1 Il12rb1 Hist1h3c Il12rb2 Csf3r Hist1h3f Il17rc Il11 Stx3 Il18 LOC684819 Hist1h3a Il16 Ctf1 Il1a Casp1 Il25 Osmr Il17rb Il17ra Il17re Il27ra LOC684762 Socs1 Cntfr Osm Psmc5 Pik3cb Psma1 Psma4 Ptpn11 Psmc1 Tec Psma3 Psmc4 Psma6 Psme1 Psme2 Sos1 Vamp7 Shc1 Grb2 DETOXIFICATION OF REACTIVE OXYGEN SPECIES%REACTOME%R-RNO-3299685.1 Detoxification of Reactive Oxygen Species Txn2 Gstp1 LOC100910067 Cat Sod1 Sod3 Txnrd2 Nudt2 Nox4 Ero1l Sod2 Txnrd1 Gsr Prdx1 P4hb Gpx8 Gpx7 Gpx6 Ncf1 Ncf4 Prdx3 Txn1 Cybb Cyba Ccs Prdx6 PLASMA LIPOPROTEIN CLEARANCE%REACTOME%R-RNO-8964043.1 Plasma lipoprotein clearance Nr1h3 Nr1h2 Ldlr Cltc Scarb1 Cubn Amn Clta Hdlbp Apoa1 Ap2s1 Ap2a1 Ap2m1 Ap2a2 Pcsk9 Apobr Vldlr Npc1 Nceh1 Lipa Mylip Soat1 Soat2 Apob Apoe Apoc1 LOC100910181 Apoc4 Ldlrap1 PEROXISOMAL LIPID METABOLISM%REACTOME%R-RNO-390918.1 Peroxisomal lipid metabolism Amacr Phyh Nudt7 Abcd1 Acot6 Acot4 Acot8 Acox1 Ehhadh Eci3 Hsd17b4 Mlycd Crot Acoxl Acaa1a Acaa1b Acox3 Acox2 Hao2 Aldh3a2 Slc27a2 LOC100910957 Slc25a17 Crat Acbd5 Hacl1 Acbd4 GAP JUNCTION ASSEMBLY%REACTOME%R-RNO-190861.1 Gap junction assembly Gja1 Gja5 Gjd4 Gja3 Gja8 Gja4 Gjb6 Gjb2 Gja10 Gjd2 Gjb3 Gjb4 Gjc1 Gjc2 Gjb1 DNA DAMAGE RECOGNITION IN GG-NER%REACTOME DATABASE ID RELEASE 66%10146144 DNA Damage Recognition in GG-NER Ddb2 Yy1 Ddb1 Rbx1 Actr8 Cops4 Cops6 Actl6a Mcrs1 Cops3 Ino80e Cops8 Ino80d Nfrkb Cops2 Actb Parp2 Parp1 Rad23a Rad23b Cops7b Ino80 Cops7a Cul4b Cul4a Xpc Ruvbl1 Ino80b Ino80c MITOTIC METAPHASE AND ANAPHASE%REACTOME DATABASE ID RELEASE 66%10145109 Mitotic Metaphase and Anaphase Cenpn Psmc6 Zwilch Cenpl Nup43 Cenpo Psmb10 Nup133 Dync1li2 Psmb8 Cenpt Psmb9 Cenpu Psmb4 Psmb11 Bub3 Bub1 Psmb5 Psmf1 Psmb6 Spdl1 Psmd4 Kntc1 Psmb2 Dync1i2 Psmd5 LOC100910252 Psmd8 Mad1l1 Stag1 Psmd9 Psmb3 Psma8 Cenpk Cenph Nup37 Cenpi Psmd11 Psmd12 Pds5b Pds5a Cenpf Cdca5 Psmd13 Rad21 Cenpe Psmd14 Smc1a Cenpm Stag2 Smc3 Ahctf1 Ndel1 Rcc2 Pafah1b1 Mis12 Dynll2 Psmc3 Ndc80 Cenpc Cenpa Dync1i1 Ranbp2 Birc5 Taok1 Ube2d1 Ppp2cb Ppp2ca Ppp2r1a Nup85 Anapc7 Cdc26 Cdc27 Cdc23 Pttg1 Ube2c Anapc16 Ppp2r1b Cdc16 Anapc4 Anapc2 Anapc1 Nup98 Nup107 Anapc11 Anapc15 Anapc10 Fbxo5 Dync1h1 Cdca8 Dync1li1 Rangap1 Ppp1cc LOC100909468 Aurkb Sec13 Xpo1 LOC100911204 Spc24 Spc25 Hdac8 Itgb3bp Sgol2 Ppp2r5e Incenp G6pc Nsl1 B9d2 Cdc20 Kif2a Kif2c Kif2b Vrk2 Psmb7 Bub1b Psmb1 Kif18a Ppp2r5c Vrk1 Ppp2r5a Ppp2r5b Zwint Dsn1 Espl1 Mad2l1 Casc5 Clasp2 Ercc6l Psma5 Nuf2 Clasp1 LOC679582 Psma2 Mapre1 Psmc5 Psma1 Pmf1 Psmd2 Psma4 Psmc1 Psma3 Psmc4 Psma6 Ckap5 Psmc2 Psme1 Ska2 Psme2 Psmd1 Psmd7 Sgol1 Zw10 Psmd3 Ska1 Psmd6 POST NMDA RECEPTOR ACTIVATION EVENTS%REACTOME%R-RNO-438064.1 Post NMDA receptor activation events Grin2d Rras Camk2g Grin2b Grin1 Nefl Rasgrf1 Raf1 Dlg1 Dlg2 Dlg3 Camk2d Actn2 Camk2a Rps6ka2 Rps6ka1 Lrrc7 Rps6ka3 Adcy3 Adcy8 Camkk1 Pdpk1 Mapk1 Creb1 Rps6ka6 Hras Camk4 Dlg4 MAP KINASE ACTIVATION%REACTOME DATABASE ID RELEASE 66%10145160 MAP kinase activation Map2k7 Ripk2 Map2k6 Dusp3 Map2k4 Map3k8 Dusp4 Traf6 Cul1 Vrk3 Rps6ka2 Rps6ka1 Rps6ka3 Rps6ka5 LOC100912585 Tab1 Dusp7 Dusp6 Atf1 Atf2 Map3k7 Irak2 LOC100910771 Ube2n Jun Ppp2cb Ppp2ca Skp1 Ppp2r1a Nfkb1 Mapk9 Mapk8 Fos Mapk7 Fbxw11 Chuk Ppp2r1b Mapkapk3 Btrc Mapkapk2 Mapk1 LOC100362142 Nod1 Nod2 Creb1 Tab2 Tab3 LOC100912618 Ube2v1 Ikbkb Mapk14 Tnip2 Mapk11 Mapk10 NUCLEOBASE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 66%10144842 Nucleobase biosynthesis Impdh1 Impdh2 Cad Pfas Ppat LOC100912917 Adss Gmps Lhpp Atic Gart Adsl Umps Adssl1 Dhodh Paics MITOCHONDRIAL TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 66%10145689 Mitochondrial tRNA aminoacylation Ppa2 PI3K AKT ACTIVATION%REACTOME DATABASE ID RELEASE 66%10145352 PI3K AKT activation Pik3cb Ntrk1 Ngf Rhoa Pik3r1 Irs2 Pik3r2 Irs1 PTK6 REGULATES PROTEINS INVOLVED IN RNA PROCESSING%REACTOME DATABASE ID RELEASE 66%10146207 PTK6 Regulates Proteins Involved in RNA Processing Khdrbs2 Khdrbs1 Ptk6 Khdrbs3 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE%REACTOME%R-RNO-204998.1 Cell death signalling via NRAGE, NRIF and NADE Aph1b Psenen Aph1a Ngfr LOC100911293 Psen2 Psen1 Traf6 Ncstn Rac1 Casp3 Sqstm1 Itgb3bp Arhgef6 Arhgef5 Arhgef39 Arhgef7 Arhgef37 Arhgef38 Arhgef33 Prex1 Itsn1 Arhgef2 LOC102556447 Arhgef4 Arhgef3 Plekhg5 Arhgef19 Arhgef18 Plekhg2 Ngf Kalrn Bcl2l11 LOC100912512 Vav2 Gna13 Casp2 Vav1 Arhgef11 Akap13 Ywhae Arhgef16 Arhgef15 Bad Net1 Ect2 Arhgef26 Fgd2 Mapk8 Mcf2l Tiam1 Tiam2 Vav3 Fgd3 Sos2 Ngef Sos1 Ngfrap1 SELENOAMINO ACID METABOLISM%REACTOME%R-RNO-2408522.1 Selenoamino acid metabolism Txnrd1 Scly Mat1a CELL CYCLE CHECKPOINTS%REACTOME DATABASE ID RELEASE 66%10144741 Cell Cycle Checkpoints Cenpn Zwilch Rfc2 Cenpl Cenpo Dync1li2 Mdm2 Cenpt Cenpu Bub3 Bub1 Spdl1 Kntc1 Dync1i2 Mad1l1 Cenpk Cenph Cenpi Pias4 Cenpf Cenpe Cenpm Uimc1 Ahctf1 Ndel1 Rcc2 Pafah1b1 Sumo1 Rpa3 Mis12 Dynll2 Brca1 Ndc80 Blm Cenpc Mdc1 Ube2v2 Cenpa Dync1i1 Ube2n Rfc5 Rfc4 Birc5 Rfc3 Rfwd2 Taok1 Ube2d1 Tp53bp1 Herc2 Rpa1 Rpa2 Nup85 Anapc7 Cdc26 Cdc27 Cdc23 Ube2c Cdkn1a Cdkn1b Anapc16 Cdc16 Anapc4 Anapc2 Anapc1 Slc25a16 Nup98 Nup107 Anapc11 Anapc15 Anapc10 Cdca8 Cdc25c Rangap1 Ppp1cc LOC100909468 Aurkb Sec13 Xpo1 LOC100911204 Spc24 Spc25 Itgb3bp Sgol2 Ppp2r5e Incenp G6pc Nsl1 B9d2 Cdc20 Kif2a Kif2c Kif2b Psmb7 Bub1b Psmb1 Kif18a Ppp2r5c Ppp2r5a Ppp2r5b Zwint Dsn1 Mad2l1 Casc5 Clasp2 Ercc6l Nuf2 Psma5 Clasp1 LOC679582 Mapre1 Psma2 Pmf1 Psmd2 Psmc2 Ckap5 Ska2 Psmd1 Psmd7 Sgol1 Zw10 Psmd3 Ska1 Psmd6 Rhno1 Bard1 Psmc6 Wrn Nup43 Psmb10 Topbp1 Nup133 Rbbp8 Rmi1 Rmi2 Psmb8 Psmb9 Psmb4 Psmb11 Psmb5 Psmf1 Psmb6 Rad50 Bre Psmd4 Psmb2 Psmd5 Psmd8 Psmd9 Psmb3 Brcc3 Psma8 Nup37 Psmd11 Psmd12 Ccna2 Ccna1 Ccne2 Psmd13 Psmd14 Ccne1 Phf20 Atm Mcm2 Atrip Mcm4 Mcm3 Cdk2 Mcm5 Clspn Mcm6 Mcm10 Rad1 Psmc3 Atr Mcm8 Mcm7 Rad17 Orc4 Orc5 Orc6 Orc1 Orc2 Ranbp2 Orc3 Cdc7 Rad9a Cdc6 Nbn Rad9b Mre11a Cdc45 Hus1 Babam1 Ppp2cb Ywhah Ppp2ca Ywhag Ppp2r1a Sfn Ywhaz Ywhab Ywhaq Ywhae Ppp2r1b Hist1h2bo Dync1h1 Hist1h2bcl1 Hist1h2bk Dync1li1 Zfp385a LOC100910200 Whsc1 H2afx Hist1h4b Rnf8 Hist1h2bh LOC100912290 LOC686349 Hist1h4m LOC100912338 Hist2h4 Hist1h2bq LOC100364835 Fam175a LOC100910954 Cdk1 Mdm4 Chek2 Gtse1 Psmc5 Psma1 Psma4 Cdc25a Psmc1 Wee1 Psma3 Pkmyt1 Psmc4 Psma6 Psme1 Hist1h2bg Psme2 LOC680097 LOC684797 LOC100912418 Hist1h2ba Hist3h2bb NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC)%REACTOME%R-RNO-975957.1 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Rnps1 LOC100912571 Magohb Rps20 Rps27l Rbm8a LOC100360573 Eif4g1 Rps4x LOC100359951 LOC100359593 Rpl30 Rpl4 LOC100359503 Rplp0 LOC100362640 Rpl6 Rpl13a Rpl26 Rps3 LOC100363800 Rps15a LOC685963 Rpl32 Rps2 Rps13 Gspt1 Rps12 Pnrc2 Pabpc2 Pabpc6 LOC100911372 Rplp1 LOC100361854 Rpl39 LOC684988 Rpl38 LOC103689992 Gspt2 Rps5 Rpl22 Rps7 Rpl23 Rpl10l Rps6 Smg8 Upf1 Rpl15 RGD1563300 Rpl19 Rpl10a Smg9 LOC100362830 LOC690468 Rpl29 LOC100363012 Smg7 Smg6 LOC680559 Smg5 Rpl39l LOC100362149 Upf3b Rpl41 LOC100912182 LOC100360057 Upf3a Rpl36al Etf1 Rpl13 Rpl3l Rpl36a Dcp1a Rps16 Ppp2ca Ppp2r1a LOC100911431 Pabpc1 Rps18 LOC100360679 Rps15 Magoh Rps3a Ncbp2 Ncbp1 Eif4a3 Ppp2r2a INTERLEUKIN-18 SIGNALING%REACTOME%R-RNO-9012546.1 Interleukin-18 signaling Il18 Il18r1 FRS-MEDIATED FGFR2 SIGNALING%REACTOME DATABASE ID RELEASE 66%10146103 FRS-mediated FGFR2 signaling Kras Frs3 Fgf23 Fgf22 Fgf4 Fgf1 Fgf3 Fgf6 Fgf5 Fgf20 Fgf16 Fgf17 Fgf10 Fgf9 Fgfr2 Fgf7 Fgf2 Fgf8 Fgfr3 Fgfr1 Fgfr4 Ptpn11 Fgf19 Hras Nras Sos1 Frs2 Grb2 BASE-EXCISION REPAIR, AP SITE FORMATION%REACTOME%R-RNO-73929.1 Base-Excision Repair, AP Site Formation Tdg Mpg Neil1 Ogg1 Neil2 Mbd4 Smug1 Ung Nthl1 Mutyh RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER%REACTOME DATABASE ID RELEASE 66%10144947 RNA Polymerase III Transcription Initiation From Type 2 Promoter Bdp1 Polr3d Polr3c Polr3a Polr3e RGD1565904 Polr3b Polr3h Polr2h Polr3k Polr2e Polr2f Polr3g Polr1c Polr2k Polr3f Gtf3c6 Gtf3c5 Gtf3c1 LOC100912534 Gtf3c3 Gtf3c4 Polr3gl Brf1 Tbp CYP2E1 REACTIONS%REACTOME%R-RNO-211999.1 CYP2E1 reactions Cyp2b2 LOC100910127 Cyp2s1 Cyp2b1 LOC100361547 Cyp2b3 Cyp2d5 Cyp2b21 LOC100911763 Cyp2c7 Cyp2b15 Cyp2e1 Cyp2b12 Cyp2d4 Cyp2f4 Cyp2d2 LOC100360055 Cyp2d3 Cyp2c6v1 TRANSLATION INITIATION COMPLEX FORMATION%REACTOME DATABASE ID RELEASE 66%10145076 Translation initiation complex formation LOC100912571 Eif3l Eif2s3 Eif3m Eif3j Eif3k Rps20 Rps27l Eif3e Eif3f Eif3b Eif3a Eif3d Eif3c LOC100360573 Eif2s1 Eif2s2 Eif4g1 Rps4x LOC100359951 LOC100359593 LOC100359503 LOC100362640 Rps3 Rps15a Rps2 Rps13 Rps12 Pabpc2 Pabpc6 LOC100911372 LOC100361854 LOC684988 LOC103689992 Rps5 Rps7 Rps6 Eif3g Eif3h Eif4a2 LOC100362830 Eif1ax Eif4a1 LOC100363012 LOC680559 LOC100911110 LOC100362149 Rps16 LOC100911431 Pabpc1 Rps18 LOC100360679 Rps15 Eif4h Eif4b Rps3a UNBLOCKING OF NMDA RECEPTORS, GLUTAMATE BINDING AND ACTIVATION%REACTOME%R-RNO-438066.1 Unblocking of NMDA receptors, glutamate binding and activation Grin2d Camk2g Grin2b Grin1 Nefl Dlg1 Gria3 Dlg2 Gria4 Dlg3 Camk2d Actn2 Camk2a Lrrc7 Dlg4 CAMK IV-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%R-RNO-111932.1 CaMK IV-mediated phosphorylation of CREB Camk4 LYSOSPHINGOLIPID AND LPA RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145608 Lysosphingolipid and LPA receptors Lppr1 Lppr4 Lppr5 Lppr2 Lppr3 Lpar5 S1pr1 S1pr5 S1pr4 S1pr3 Lpar1 Lpar3 Lpar2 S1pr2 METABOLISM OF INGESTED SEMET, SEC, MESEC INTO H2SE%REACTOME%R-RNO-2408508.1 Metabolism of ingested SeMet, Sec, MeSec into H2Se Scly Mat1a GLYCOSAMINOGLYCAN METABOLISM%REACTOME%R-RNO-1630316.1 Glycosaminoglycan metabolism Cd44 Lyve1 Has1 Has2 B3gat1 B3gat3 B3gat2 Hyal1 Hyal2 Chp1 Sdc2 Sdc3 Sdc4 Fmod Hs2st1 Ncan Hexb Hexa Chst7 Chst9 Slc9a1 Chst5 LOC102550316 Chst3 Chst2 Chst1 B3gnt4 B3gnt7 B3gnt1 B3gnt2 B3gnt3 Gpc6 Chpf2 Gpc4 Gpc2 Ndst1 Ndst2 Ndst3 Ndst4 Ogn Glb1 St3gal2 St3gal3 Slc26a2 Slc26a1 St3gal1 Gpc1 St3gal4 St3gal6 B3galt6 Slc35b2 Kera Slc35b3 Prelp LOC100911750 Cspg5 Cspg4 Acan Dsel Bcan Chsy1 LOC100910284 B4galt1 Ext1 Ext2 B4galt3 B4galt2 B4galt6 B4galt7 B4galt4 B4galt5 Hs3st3b1 Naglu Cemip Agrn Stab2 Xylt2 Chst12 Chst11 Lum Dcn Csgalnact1 Csgalnact2 Hs6st2 Chst13 Papss2 Papss1 Hs6st1 Idua Ust Chst15 Chst14 Vcan Hs3st3a1 Omd Dse Glb1l Arsb LOC100910891 Slc35d2 Gusb Hpse Hs3st5 Chpf Hs3st2 Hs3st1 Hs3st6 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 66%10144983 Resolution of AP sites via the multiple-nucleotide patch replacement pathway Rfc1 Rfc2 Parp2 Rpa3 Pole2 Parp1 Pole4 LOC100911727 Pole Polb Pold2 Pcna Pold1 Pold4 Rpa1 Rpa2 Fen1 Adprhl2 Parg Rfc5 Apex1 Rfc4 Rfc3 Lig1 IGF1R SIGNALING CASCADE%REACTOME%R-RNO-2428924.1 IGF1R signaling cascade Pik3r1 Pik3r2 Fgf23 Fgf22 Fgf4 Fgf1 Fgf3 Tlr9 Fgf6 Fgf5 Fgf20 Gab1 Pde3b Igf2 Igf1 Fgf16 Pik3c3 Fgf17 Irs2 Fgf10 Fgf9 Fgfr2 Fgf7 Fgf2 Fgf8 Pik3r4 Fgfr3 Trib3 Pdpk1 Fgfr1 Fgfr4 Pik3cb Ptpn11 Fgf19 Them4 Irs1 Frs2 Sos1 Shc1 Akt2 Grb2 CELLULAR RESPONSES TO EXTERNAL STIMULI%REACTOME%R-RNO-8953897.1 Cellular responses to external stimuli Hif1an Dync1li2 Mdm2 Vhl Rbx1 Dync1i2 Chmp4bl1 Rpa3 Ncf1 Ncf4 Cited2 Dynll2 Mapkapk5 Atg12 Map1lc3a Dync1i1 Gabarap Ube2d1 Cdk4 Nup88 Rpa1 Rpa2 Ube2d3 Chmp7 Nup85 Chmp6 Chmp3 Anapc7 Cdc26 Cdc27 Cdc23 Gabarapl2 Ube2c Cdkn1a Cdkn1b Anapc16 Cdc16 Rae1 Anapc4 Anapc2 Anapc1 Becn1 Map2k7 Nup93 Dnaja2 Camk2g Asf1a Map2k6 Dnajb6 Dnaja4 Nup98 Ets1 Map2k4 l7Rn6 Nup107 Ep400 Ets2 Tnik Fkbp5 LOC100911837 LOC100910067 Sod1 Camk2d Sod3 Mink1 Camk2a Nup210 Map3k5 Rps6ka2 Txnrd2 Uvrag Rps6ka1 Nudt2 Atg16l1 Hspa14 Wipi1 Atg7 Mtmr14 Rps6ka3 Hspa13 Wipi2 Atg13 Nox4 Atg14 Erf LOC100912585 Atg10 Ubn1 Ambra1 Nupl2 Anapc11 Dnajc7 Cabin1 Anapc15 Mt3 Hdac6 Atg3 Ccar2 Nupl1 Anapc10 Hira Fzr1 Hsph1 Hspa12b Hspa12a Nup205 G6pc Nup155 Psmb7 Psmb1 Sod2 Capzb Mtmr3 Nup153 P4hb Psma5 Pik3c3 Tpr Pik3r4 Psma2 Psmd2 Nup54 Psmc2 Pom121 Psmd1 Psmd7 Nup62 Prdx6 Psmd3 Psmd6 Psmc6 Nup43 Psmb10 Nup133 Psmb8 Psmb9 Psmb4 Aaas Psmb11 Psmb5 Psmf1 Psmb6 Rad50 Psmd4 Psmb2 Psmd5 Npap60 Psmd8 Psmd9 Psmb3 Nup35 Psma8 Nup37 Psmd11 Psmd12 Ccna2 Ccna1 Ccne2 Txnrd1 Psmd13 Psmd14 Ccne1 RragB Prkab1 Prkab2 Atm Gsr Cdk2 Egln2 Tceb2 Tceb1 Cul2 Hif1a Limd1 Psmc3 Atr Epas1 Hif3a Egln3 Ajuba Ranbp2 Nbn Mre11a Hsbp1 Dnajb1 Cryab Hsf1 Hspb8 Hspa1l Hsp90ab1 Akt1s1 Hspa2 Cat Jun Ero1l Ywhae Phc1 Phc2 Bag1 Mtor Bag2 Prdx1 Bag4 Mapk9 Bag5 Mapk8 Rheb Prkag3 Gpx8 Fos Gpx7 Rptor Bag3 Lamtor4 Mapk7 Gpx6 Hspa9 Tsc1 Lamtor5 Hspa5 Capza2 Txn1 Prdx3 Capza3 Stip1 Mlst8 Id1 Mapkapk3 Prkaa1 Map4k4 Tsc2 Rraga Hspa4 Mapkapk2 Ccs Mapk1 Prkaa2 Rragc Rb1cc1 Atg101 Rragd Atg4c Slc38a9 Atg4d Gabarapl1 Atg9a Atg9b Wdr45b Mapk14 Mapk11 Mapk10 Chmp2b Vcp Chmp2a Ulk1 Actr10 Lamtor3 Chmp4b Chmp4c Hist1h2bo Dync1h1 Tinf2 Scmh1 Hist1h2bcl1 Hist2h3c2 Cbx4 Hist1h2bk Cbx2 Lamtor2 H3f3b Cbx8 Lamtor1 Cbx6 Bmi1 Dync1li1 Rnf2 Kdm6b LOC103692716 Ring1 Ptges3 Cybb Cyba Phc3 Ptges3l1 Dctn5 Dctn6 Cdkn2b Terf2ip Fkbp4 Crebbp Cdkn2c Dctn4 Pgr Cdk6 Eed Dctn1 LOC100910200 Txn2 H2afx Dctn2 Hist1h4b Gstp1 LOC684841 Hist1h2bh Acd LOC100912290 Rbbp7 Pot1b Hist1h2ail1 Hist1h4m LOC102549173 LOC103690002 Dctn3 Ehmt2 LOC100910152 Pot1 Ehmt1 LOC100912338 Hist1h3c H2afb3 Hist1h3f Hist2h4 LOC684819 Hist1h3a H2afj Hist2h2aa3 Hist1h2bq Hist2h2aa2 LOC100364835 LOC684762 Terf1 Terf2 LOC100910954 Arnt Mdm4 Psmc5 Psma1 Psma4 Psmc1 Psma3 Psmc4 Psma6 Psme1 Hist1h2bg Psme2 Ezh2 LOC680097 LOC684797 Actr1a LOC100912418 Hist1h2ba Hist3h2bb CHYLOMICRON CLEARANCE%REACTOME%R-RNO-8964026.1 Chylomicron clearance Apob Apoe Ldlrap1 Ldlr HIGHLY SODIUM PERMEABLE ACETYLCHOLINE NICOTINIC RECEPTORS%REACTOME%R-RNO-629587.1 Highly sodium permeable acetylcholine nicotinic receptors Chrnb4 Chrna4 Chrnb2 Chrne Chrnd Chrna3 NEGATIVE REGULATION OF MAPK PATHWAY%REACTOME%R-RNO-5675221.1 Negative regulation of MAPK pathway Dusp16 Kras Ksr1 Ppp2r5e Dusp4 Raf1 Ppp5c Dusp10 Paqr3 Ppp2r5c Ppp2cb Ppp2r5a Ppp2ca Ppp2r1a Ppp2r5b Dusp7 Dusp6 Ywhab Pbp2 Dusp9 Dusp2 Dusp5 Pebp1 Ppp2r1b Dusp1 LOC100909468 Mark3 Araf Mapk1 Hras Nras Map2k2 SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE%REACTOME DATABASE ID RELEASE 66%10145899 Synthesis of PIPs at the late endosome membrane Vac14 Pik3c3 Mtmr7 Mtmr2 Fig4 Pikfyve Pik3c2a Pik3r4 Mtmr4 ACETYLCHOLINE REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 66%10145585 Acetylcholine regulates insulin secretion Plcb1 Marcks Prkca Plcb3 Gnaq Gna11 Gna14 Gna15 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS%REACTOME%R-RNO-674695.1 RNA Polymerase II Pre-transcription Events Gtf2h1 Gtf2h2 Mnat1 RGD1565904 Leo1 Polr2g Polr2h Polr2e Supt16h Polr2f Polr2j Polr2k Polr2d Ctr9 Polr2i Polr2b Polr2c Polr2a Wdr61 LOC100912534 Gtf2f1 Gtf2f2 Ell Gtf2a1 Tceb2 Tceb1 Atp5c1 Iws1 Tcea1 Taf7l Ccnh Gtf2h3 Paf1 Gtf2h5 Tbp Gtf2h4 Cdc73 Ccnt2 Aff4 Gtf2e1 Tceb3 Gtf2e2 Rtf1 Cdk9 Supt6h Eaf1 Taf11 Eaf2 Ercc3 Taf15 Taf2 Taf13 Taf9 Ccnk Taf12 LOC100911822 Mllt1 Supt5h Taf7 Taf4b Ercc2 Taf3 Taf6 Taf5 Ncbp2 Ncbp1 Supt4h1 Cdk7 Nelfe Taf10 Nelfa Nelfb Gtf2b Ssrp1 Taf9b REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA)%REACTOME DATABASE ID RELEASE 66%10145590 Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) Carm1 Ncoa2 Helz2 Sin3a Tbl1xr1 Sin3b Med1 Rxra Hdac3 Ncor2 Tgs1 Fabp1 Smarcd3 Ncoa6 Ppara Tbl1x Crebbp Ncoa1 CONJUGATION OF SALICYLATE WITH GLYCINE%REACTOME%R-RNO-177128.1 Conjugation of salicylate with glycine Glyatl3 Glyat CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY%REACTOME DATABASE ID RELEASE 66%10145212 Cyclin A:Cdk2-associated events at S phase entry Psmc6 Psmb10 Psmb8 Psmb9 Psmb4 Psmb5 Psmf1 Psmb6 Mnat1 Psmd4 Psmb2 Cul1 Psmd5 Ptk6 Psmd8 Psmd9 Psmb3 Psmd11 Psmd12 Ccna2 Ccna1 Ccne2 Psmd13 Psmd14 Ccne1 Fzr1 Cdk2 Cks1l Cables1 Psmc3 Ccnh Cks1b Akt2 G6pc Rb1 Cdk4 Akt1 Psmb7 Psmb1 Ccnd1 Skp1 Psma5 Skp2 Cdkn1a Cdk7 Cdkn1b Psma2 Psmc5 Akt3 Psmd2 Psma1 Cdc25b Psma4 Psmc1 Cdc25a Wee1 Psma3 Psmc4 Psmc2 Psma6 Psme1 Psmd1 Psme2 Psmd7 Psmd3 Psmd6 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 66%10145513 Nuclear Receptor transcription pathway Nr1d1 Nr1h4 Nr1d2 Nr1h3 Nr1h2 Nrbf2 Vdr Med1 Nr5a1 Rarg Rxra Rora Esr2 Nr1i2 Pparg Nr2c2ap Hnf4a Hnf4g Esrrg Ppara Nr4a3 Nr4a1 Nr4a2 LOC100363472 Ppard Nr1i3 Nr0b1 Nr0b2 Nr5a2 Esrra Esrrb Rxrg Nr6a1 Nrbp1 Nr2c2 Nr2c1 Esr1 Rara Rarb Nr2e1 Nr2f6 Nr2f1 Pgr Rorb Nr2e3 Thra Thrb AURKA ACTIVATION BY TPX2%REACTOME%R-RNO-8854518.1 AURKA Activation by TPX2 Dync1i2 Cep57 LOC691918 Haus3 Ninl Aurka Akap9 Ccp110 Dync1h1 Pafah1b1 LOC103692716 Dctn1 Cntrl Dctn2 Cep76 Pcm1 Cep78 LOC100911033 Cep164 Dctn3 Cep41 Ofd1 Sdccag8 Tubb5 Prkar2b Cenpj Ywhag Ppp2r1a Plk4 Ywhae LOC100912076 Tubg2 Haus2 Haus1 Haus5 Tpx2 Alms1 Clasp1 Haus4 Odf2 Tubb4a Cdk1 Nek2l1 Ssna1 Mapre1 Tubg1 Cep63 Prkaca Csnk1d Cep131 Tuba4a Cep250 Cep135 Csnk1e Ckap5 Cdk5rap2 Pcnt Nek2 Cep72 Sfi1 Cep70 Actr1a Nedd1 FATTY ACIDS%REACTOME%R-RNO-211935.1 Fatty acids Cyp2b2 LOC100910127 Cyp4a2 Cyp2b1 Cyp4f39 Cyp4a1 Cyp2b3 Cyp2d5 Cyp2b21 Cyp4f6 Cyp4a8 LOC100911763 Cyp2b15 Cyp2b12 LOC100912391 Cyp2d4 Cyp2f4 Cyp4f17 Cyp2d2 Cyp2j10 LOC100360055 Cyp2d3 Cyp4f18 MITOTIC PROPHASE%REACTOME DATABASE ID RELEASE 66%10145525 Mitotic Prophase Nup93 Nup43 Nup98 Nup133 Nup107 Rab2a Aaas Nup210 Npap60 Nup35 Nup37 Nupl2 Nupl1 Hist1h2bo Hist1h2bcl1 Cnep1r1 Hist2h3c2 Gorasp2 Hist1h2bk H3f3b LOC102555167 Numa1 Ensa Lemd2 Arpp19 Nup205 Nek6 Rab1b Rab1a Ranbp2 Blzf1 Setd8 Nek7 LOC100909949 LOC100910200 Mcph1 H2afx RGD1563307 Hist1h4b LOC684841 Hist1h2bh Rb1 LOC100912290 Nup155 Gorasp1 Hist1h2ail1 Hist1h4m Lemd3 LOC102549173 LOC103690002 Lmna LOC100910152 LOC100912338 Hist1h3c Ncaph2 H2afb3 Hist1h3f Ctdnep1 Nup88 Hist2h4 LOC684819 Hist1h3a Prkcb H2afj Smc4 Tmpo Hist2h2aa3 Hist1h2bq RGD1310212 Hist2h2aa2 Smc2 Nup85 LOC100364835 LOC684762 Nup153 Tpr Cdk1 Lmnb1 Rae1 Ncapg2 Mapk1 Nup54 Lpin2 Lpin3 Prkca Lpin1 Hist1h2bg Pom121 LOC680097 LOC684797 Nup62 LOC100912418 LOC100363782 Hist1h2ba Hist3h2bb THE RETINOID CYCLE IN CONES (DAYLIGHT VISION)%REACTOME DATABASE ID RELEASE 66%10145969 The retinoid cycle in cones (daylight vision) Opn1sw Awat2 Dhrs3 Rlbp1 Opn1mw TERMINATION OF O-GLYCAN BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 66%10145784 Termination of O-glycan biosynthesis St6gal1 St3gal2 Muc13 St6galnac4 St3gal3 Muc1 St6galnac3 Muc15 St3gal1 Muc20 St6galnac2 St3gal4 GLYCOGEN METABOLISM%REACTOME DATABASE ID RELEASE 66%10144770 Glycogen metabolism Phkb Epm2a Phkg1 Pgm2l1 Gaa Agl Ugp2 Pgm2 Pygl Pgm1 Pygm Phkg2 Gyg1 Gys1 Gys2 Ppp1r3c Nhlrc1 Phka1 INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES%REACTOME%R-RNO-499943.1 Interconversion of nucleotide di- and triphosphates Nme2 Txnrd1 Gsr Tyms Dtymk LOC305806 Nme3 Nudt13 Nme1 Ak5 Ak4 Ak6 Ak8 Rrm2b Txn1 Dut Ctps2 Ctps1 Glrx Rrm2 Rrm1 Dctd LOC100360124 LOC100359853 Guk1 N-GLYCAN ANTENNAE ELONGATION%REACTOME DATABASE ID RELEASE 66%10145781 N-Glycan antennae elongation B4galt3 St6gal1 Mgat5 B4galt2 B4galt6 B4galt4 B4galt5 St8sia3 Mgat4b Mgat4a St3gal4 B4galt1 O-LINKED GLYCOSYLATION%REACTOME%R-RNO-5173105.1 O-linked glycosylation Adamts13 Adamts15 Adamts19 Pofut2 Adamts16 Adamts17 Pomk Adamts12 Spon2 Galnt9 LOC102550196 Spon1 Gcnt1 LOC100911750 Large A4gnt Muc13 C1galt1 Gyltl1b Muc15 C1galt1c1 Galnt16 Adamts1 Galnt18 Galnt14 Adamts6 Galnt15 Adamts7 Galnt12 Galnt13 Adamts9 Sspo B3gntl1 Galnt10 Cfp Sema5b Thbs2 Thbs1 B4galt6 Adamtsl2 B4galt5 Adamtsl3 Muc20 Thsd1 Adamtsl4 Dag1 LOC102554393 Sbspon Adamts4 Adamts3 Adamts5 Sema5a B3gnt4 B3gnt7 B3gnt1 B3gnt2 B3gnt3 Adamts14 St6galnac2 B3galnt2 B3gnt6 Pomt2 Thsd7a Galntl5 St6gal1 Pomgnt2 Galnt6 Galnt5 Pomt1 St6galnac4 B3gnt8 St3gal2 Muc1 St6galnac3 St3gal3 B3gnt5 Chst4 St3gal1 Thsd7b Galnt1 Galnt7 St3gal4 Galnt3 Galnt2 Pomgnt1 DNA REPLICATION INITIATION%REACTOME DATABASE ID RELEASE 66%10144718 DNA replication initiation Pole2 Pole4 Prim2 Pola2 Pole Prim1 PURINE SALVAGE%REACTOME DATABASE ID RELEASE 66%10144873 Purine salvage Gmpr2 Ampd1 Gmpr Adal Pnp Ampd3 Dck Dguok Aprt Hprt1 Ada Ampd2 G-PROTEIN BETA:GAMMA SIGNALLING%REACTOME%R-RNO-397795.1 G-protein beta:gamma signalling Pik3r5 Plcb1 Pik3r6 Plcb3 Akt1 Pik3cg Gnb3 Gnb5 Gnb2 Gnb1 Pdpk1 Gng13 Gng12 Gng11 Akt3 Rhoa LOC100912034 Gnb4 Gng4 Gngt2 Gng5 Gngt1 Gng8 Gng10 Akt2 Gng3 ALTERNATIVE COMPLEMENT ACTIVATION%REACTOME DATABASE ID RELEASE 66%10145211 Alternative complement activation Cfd C3 Gzmm C2 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP)%REACTOME DATABASE ID RELEASE 66%10145264 Senescence-Associated Secretory Phenotype (SASP) Rps6ka2 Rps6ka1 Rps6ka3 LOC100912585 Anapc11 Ccna2 Anapc15 Ccna1 Anapc10 Fzr1 Hist1h2bo Hist1h2bcl1 Hist2h3c2 Hist1h2bk Cdk2 H3f3b Cdkn2b Cdkn2c Cdk6 LOC100910200 H2afx Hist1h4b LOC684841 Hist1h2bh LOC100912290 Ube2d1 Hist1h2ail1 Hist1h4m Cdk4 LOC102549173 Ehmt2 LOC103690002 LOC100910152 Ehmt1 LOC100912338 Hist1h3c H2afb3 Hist1h3f Hist2h4 LOC684819 Hist1h3a H2afj Hist2h2aa3 Hist1h2bq Hist2h2aa2 LOC100364835 LOC684762 Anapc7 Cdc26 Cdc27 Cdc23 Ube2c Mapk7 Cdkn1a Cdkn1b Anapc16 Cdc16 Anapc4 Anapc2 Mapk1 Anapc1 Hist1h2bg LOC680097 LOC684797 LOC100912418 Hist1h2ba Hist3h2bb SIGNALING BY INSULIN RECEPTOR%REACTOME%R-RNO-74752.1 Signaling by Insulin receptor Atp6v1d Fgf23 Fgf22 Fgf4 Fgf1 Fgf3 Tlr9 Fgf6 Fgf5 Fgf20 Atp6v1g1 Gab1 Pde3b Atp6v1g2 Atp6v0a4 Atp6v1b2 Fgf16 Atp6v0a2 Fgf17 Atp6v1h Irs2 Atp6v1f Fgf10 Fgf9 Fgfr2 Fgf2 Fgf7 Fgf8 Fgfr3 Trib3 Fgfr1 Fgfr4 Grb10 Insr Ins1 Ins2 Fgf19 Them4 Irs1 Frs2 Atp6v0c Akt2 Pik3r1 Pik3r2 Tcirg1 Atp6v0d1 Atp6v1c2 Atp6v0d2 Atp6v1a Atp6v0e2 Atp6ap1 Atp6v0e1 Atp6v1g3 Atp6v1e1 Atp6v1e2 Atp6v1c1 Atp6v0a1 Pik3c3 Pik3r4 Pdpk1 Mapk1 Pik3cb Ptpn11 Sos1 Shc1 Grb2 SIGNALING BY NODAL%REACTOME%R-RNO-1181150.1 Signaling by NODAL Smad3 Smad2 Foxo3 Foxh1 Drap1 PI3K EVENTS IN ERBB2 SIGNALING%REACTOME DATABASE ID RELEASE 66%10145823 PI3K events in ERBB2 signaling Gab1 Ereg Nrg1 Btc LOC102552659 Pik3r1 Erbb3 Erbb2 Nrg3 Egfr Hbegf Nrg4 Erbb4 Nrg2 Grb2 U12 DEPENDENT SPLICING%REACTOME%R-RNO-72165.1 U12 Dependent Splicing Snrpf Ddx23 RGD1565904 Snrpd1 Eftud2 Polr2g Polr2h Snrpd2 Snrnp25 Snrpd3 Polr2e Zrsr1 Polr2f Polr2j Zcrb1 Zmat5 Sf3b2 Polr2k Snrnp48 Sf3b4 Polr2d Rnpc3 Sf3b3 Polr2i Zrsr2 Polr2b Snrnp35 Sf3b5 Polr2c Polr2a Pdcd7 Gtf2f1 LOC100912534 Gtf2f2 Lsm2 Snrnp200 Prpf6 Sf3b1 Prpf8 Ddx42 Srsf6 Srsf7 Srsf2 LOC100359574 LOC100911822 Ncbp2 Srsf1 Ncbp1 Ybx1 Nhp2l1 Txnl4a Snrpb RHO GTPASES ACTIVATE PKNS%REACTOME%R-RNO-5625740.1 RHO GTPases activate PKNs Rac1 Kdm1a Hist1h2bo Hist1h2bcl1 Hist2h3c2 Pkn1 Hist1h2bk H3f3b Pkn2 Pkn3 Cdc25c Ppp1r12a Ppp1cb Ppp1r14a LOC100910200 H2afx Hist1h4b LOC684841 Hist1h2bh LOC100912290 Hist1h2ail1 Hist1h4m LOC102549173 LOC103690002 LOC100910152 LOC100912338 Hist1h3c H2afb3 Hist1h3f Ywhah Hist2h4 LOC684819 Ywhag Sfn Hist1h3a Ywhaz H2afj Hist2h2aa3 Hist1h2bq Hist2h2aa2 Ywhab Ywhaq Ywhae LOC100364835 LOC684762 Ncoa2 Pdpk1 Rhoa Hist1h2bg LOC680097 LOC684797 LOC100912418 Rhob Hist1h2ba Hist3h2bb Rhoc C6 DEAMINATION OF ADENOSINE%REACTOME%R-RNO-75102.1 C6 deamination of adenosine Adarb1 Adar SERINE BIOSYNTHESIS%REACTOME%R-RNO-977347.1 Serine biosynthesis Psat1 Phgdh Serinc4 Psph Serinc2 Serinc3 Srr Serinc1 NEGATIVE REGULATION OF THE PI3K AKT NETWORK%REACTOME%R-RNO-199418.1 Negative regulation of the PI3K AKT network Ereg Pten Cd80 Nrg1 Cd86 Btc LOC102552659 Erbb3 Erbb2 Nrg3 Egfr Hbegf Esr2 Rac1 Traf6 Nrg4 Fgf23 Fgf22 Fgf4 Fgf1 Il33 Fgf3 Fgf6 Fgf5 Fgf20 Gab1 Pip5k1c Pip5k1b Fgf16 Fyn Pip5k1a Fgf17 Irs2 Fgf10 Fgf9 Fgfr2 Fgf7 Cd19 Fgf2 Fgf8 Fgfr3 Il1rap Trib3 Fgfr1 LOC100909468 Fgfr4 Hgf Esr1 Insr Ins1 Rac2 Ins2 Fgf19 Erbb4 Them4 Irs1 Frs2 Pip4k2b Pip4k2c Akt2 Nrg2 Src Ppp2r5e Pik3r1 Pik3r3 Pdgfra Pik3r2 Pdgfrb Pik3ap1 Il1rl1 Akt1 Cd28 Icos Phlpp1 Ppp2r5c Ppp2cb Pdgfa Ier3 Ppp2r5a Ppp2ca Pdgfb Ppp2r1a Ppp2r5b Pik3cd Vav1 Irak4 Ppp2r1b Mapk1 Pik3cb Akt3 Ptpn11 Rhog Kit Myd88 Kitlg Grb2 METABOLISM OF FOLATE AND PTERINES%REACTOME%R-RNO-196757.1 Metabolism of folate and pterines Mthfs Mthfd1l Mthfd2l Dhfr Mthfr Mthfd2 Mthfd1 Shmt1 Aldh1l2 Aldh1l1 Slc19a1 Slc25a32 Shmt2 Slc46a1 Folr2 ACTIVATION OF C3 AND C5%REACTOME%R-RNO-174577.1 Activation of C3 and C5 C4a C4b C3 LOC100909666 LOC102549354 C2 SHC-MEDIATED CASCADE:FGFR3%REACTOME%R-RNO-5654704.1 SHC-mediated cascade:FGFR3 Kras Fgf16 Fgf17 Fgf9 Fgf2 Fgf8 Fgfr3 Fgf23 Fgf4 Fgf1 Fgf5 Hras Nras Sos1 Shc1 Fgf20 Grb2 BIOLOGICAL OXIDATIONS%REACTOME%R-RNO-211859.1 Biological oxidations Nr1h4 Bpnt1 Smox Abhd14b Cyp1b1 Nat1 Glyatl3 RGD1564480 Acsm1 Nat2 Sult6b1 Podxl2 Glyat Sult4a1 Sult2a1 Nat3 Cyp46a1 Acy3 LOC100910526 Hpgds RGD1562392 Akr7a2 Maoa ste2 Impad1 Tpst1 Tpst2 Sult2b1 NEWGENE_1306455 LOC100910057 Aldh2 Sult1b1 Comt LOC100910881 Sult1a1 Paox Sult1c2 Acy1 Cyp4f39 Cyp39a1 Pomc Ugp2 Cyp2d5 Fdx1 LOC100361547 Slc35d1 Cyp3a23/3a1 Cyp3a73 Cyp2u1 Gsta5 Gss Cyp2c7 Cyp2e1 Gstm4 Cyp2d4 Slc26a2 Cyp3a18 Cyp1a1 Slc26a1 Ptgs1 LOC100910877 Cyp2d2 Cyp1a2 Cyp2d3 Cyp2c6v1 Slc35b2 Slc35b3 Gstm7 Ggct Esd Gclm Gstm5 Gsto2 Gstk1 Cndp2 Gclc LOC100912430 Gstt2 Ggt7 Ggt6 Chac2 Cyp7b1 Chac1 Mgst3 Oplah Cyp7a1 Cyp21a1 Fdxr Cyp2r1 Acss2 Dpep2 Papss2 Papss1 Cyp11b2 Cyp27b1 Gstz1 Ncoa2 Cyp8b1 Akr1a1 Svs1 Dpep3 Dpep1 Doxl2 Doxl1 Cyp19a1 Fdx1l Por LOC100360055 Aoc3 Ces2c Cyp4f17 Mat1a Mat2b Mgst1 LOC100363915 Cyp4f18 Ahcy N6amt1 Ugt2b Nnmt Ugt1a8 Ugt2b37 Mat2a As3mt Ugt1a9 Tpmt Ugt1a6 Tbxas1 Ugt2b35 Mtrr Trmt112 Ugt2a1 Ugt2b15 Gsto1 Hsp90ab1 Ugt1a1 Cyp51 Mtr Ugt2b17 RGD1559459 Ugt1a7c Ugt1a5 Ugt1a3 Ugt1a2 Cyp4f6 LOC100912391 Cyp24a1 Cyp4a2 Cyp4a1 Ptgis Rxra Cyp4a8 Cyp2j10 Ptges3 Ptges3l1 Ncoa1 Cyp2b2 Cyp2c24 Cyp2s1 Cyp2b1 Gstp1 Marc2 Marc1 Aip Cyp2b3 Ephx1 Nqo2 Cyp26c1 Aldh3a1 LOC100910040 Bphl Ahrr LOC100361492 Ahr Maob LOC100910127 Ugdh Ces1d Cyp2c13 LOC100910481 Aadac Cmbl Ces2 Ces2j Cyp2b21 Arnt Ces2e Ces2g Acss1 Cbr3 Ces2h LOC100911763 Aoc1 Cyp2b15 Fmo1 Cyp2b12 Adh4 Fmo2 Cyp2f4 Cyp26a1 Adh6 Cyb5r3 Arnt2 Adh7 Cyb5b Cyp4v3 Aldh1b1 Cyp26b1 LOC100365112 NONCANONICAL ACTIVATION OF NOTCH3%REACTOME%R-RNO-9017802.1 Noncanonical activation of NOTCH3 Aph1b Psenen Ybx1 Aph1a LOC100911293 Notch3 Psen2 Psen1 Ncstn THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION)%REACTOME%R-RNO-2453902.1 The canonical retinoid cycle in rods (twilight vision) Stra6 Rlbp1 Rdh10 Rdh16 LOC100365958 LOC100362350 Rbp4 Ttr Rbp1 Abca4 Rdh11 Lrat Rpe65 Dhrs9 Cyp4v3 Myo7a Sdr9c7 Hsd17b6 REGULATION OF TNFR1 SIGNALING%REACTOME DATABASE ID RELEASE 66%10146056 Regulation of TNFR1 signaling Usp21 Birc3 Birc2 Otud7b Cyld Madd Tax1bp1 Sppl2a Clip3 Ripk1 Otulin Tnf Tradd Xiap Casp8 Tnfaip3 Rnf31 Sharpin Traf1 Usp2 Rbck1 Chuk Traf2 Usp4 Ikbkb RNA POLYMERASE II PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 66%10144902 RNA Polymerase II Promoter Escape Gtf2h1 Gtf2h2 Gtf2e1 Gtf2e2 Mnat1 RGD1565904 Taf11 Polr2g Ercc3 Taf2 Polr2h Taf15 Polr2e Polr2f Polr2j Taf13 Taf9 Polr2k Taf12 Polr2d LOC100911822 Taf7 Polr2i Taf4b Polr2b Polr2c Taf3 Ercc2 Taf6 Polr2a Taf5 Gtf2f1 LOC100912534 Gtf2f2 Gtf2a1 Cdk7 Atp5c1 Taf10 Taf7l Gtf2b Ccnh Gtf2h3 Gtf2h5 Tbp Gtf2h4 Taf9b SUMOYLATION OF DNA METHYLATION PROTEINS%REACTOME%R-RNO-4655427.1 SUMOylation of DNA methylation proteins Dnmt3b Sumo1 Dnmt1 Ube2i RUNX1 REGULATES ESTROGEN RECEPTOR MEDIATED TRANSCRIPTION%REACTOME DATABASE ID RELEASE 66%10146262 RUNX1 regulates estrogen receptor mediated transcription Esr1 Cbfb Runx1 THREONINE CATABOLISM%REACTOME DATABASE ID RELEASE 66%10146296 Threonine catabolism Sdsl Sds Hrsp12 METABOLISM OF RNA%REACTOME DATABASE ID RELEASE 66%10144827 Metabolism of RNA Thoc5 Thoc7 Gtf2h1 Thoc3 Gtf2h2 Thoc2 Thoc1 Ppie Mnat1 Thoc6 RGD1565904 Isy1 Polr2g Polr2h Polr2e Zfp473 Polr2f Polr2j Polr2k Polr2d Polr2i Polr2b Polr2c Ddx39a Polr2a Ddx39b Chtop Xab2 LOC100912534 Prpf19 Ccnh Gtf2h3 Gtf2h5 Gtf2h4 Dcp2 Exosc3 Akt1 LOC100911537 Xrn1 Dcp1a Exosc9 Ercc3 Exosc2 Exosc1 Exosc4 Exosc7 Exosc5 LOC100911822 Aqr Ercc2 Fyttd1 Prkca LOC361990 Phax Sarnp Slu7 Nop58 Lsm10 Lsm11 Psmb7 Psmb1 LOC679894 Ddx21 Poldip3 Psma5 Cdk7 Psma2 Slbp Psmd2 Psmc2 Psmd1 Psmd7 Psmd3 Psmd6 Cwc27 Cwc25 Cwc22 Snrpf Wdr33 Cnot6l Cnot11 Srsf3 Ccar1 Cdc5l Upf3b U2af2 LOC102548514 Cd2bp2 Papola Srsf6 Elavl1 Srsf7 Ppil6 Prpf38a Srsf4 Srsf5 Srsf2 Hnrnph1 Tnks1bp1 Ppih Cnot8 Rqcd1 LOC100359574 Pan2 Ppil1 Cnot3 Ppil3 Ppp2ca Elavl2 Cnot1 Srsf9 Zcchc6 Cnot2 Ppp2r1a Ppil4 Dhx38 Fblim1 Clp1 Cnot7 Hnrnph2 Cnot4 Cwc15 Cherp Magoh Hnrpd Apobec1 Ncbp2 Apobec2 Srsf1 Tbl3 LOC100363335 Tsr1 Ctnnbl1 Emg1 Ppwd1 Wdr75 LOC500684 Wtap Ncbp1 LOC680519 Apobec4 Dhx9 Wdr18 Ybx1 Wdr43 LOC100910750 Wdr46 Nhp2l1 C1d Cstf2t Nob1 Eif4a3 Fcf1 Sympk Wdr12 Mapkapk2 Bud31 Senp3 Hnrnpul1 Txnl4a LOC100910660 Hnrnpk Srrm1 Wdr36 Hnrnpu Ebna1bp2 Hnrnpr Wbp4 Smn1 Usp39 Hnrnpl Snrpa Hnrnpm Hnrnpf Cdc40 Snrpc Hnrnpa2b1 Snrpb Rpp25 RGD1565693 Riok3 Riok1 Utp14a Bysl NEWGENE_1564769 Rpp21 Pdcd11 Rpp40 Skiv2l2 Heatr1 Riok2 Rpp38 Rrp36 Rpp30 Bop1 Nxf7 Utp20 Dhx37 Gle1 Mettl14 Nxf2 Nxf1 Utp18 Gnl3 Utp15 Utp11l Pno1 Pwp2 Wbscr22 Mphosph6 Imp4 Imp3 Nop56 Tex10 Utp6 Rcl1 Nol6 Utp3 Ddx20 Ncl Gemin7l1 Nop14 Xrn2 Rrp9 Snw1 Rrp7a Mettl3 Pes1 Gemin5 Gemin7 Gemin6 Gemin8 Tcp11x2 Exosc10 Krr1 Nol9 Nxt1 Mphosph10 Gemin2 LOC100910568 Rpp14 Cirh1a Diexf RGD1563307 Ddx52 Ltv1 Wdr3 A1cf Snupn Noc4l Ddx49 Ddx47 Las1l Fbl Csnk1d Csnk1e Hspb1 Nup88 Supt5h Dcaf13 Nup85 Rnmt Rngtt Rae1 Rnps1 Nup93 Dhx16 Dhx15 Sugp1 Nup98 Prpf40a Sart1 Snrpb2 Nup107 Magohb Phf5a Rbm8a Ddx23 Pcf11 Fip1l1 Hnrnpa0 U2surp Nudt21 Nup210 Snrpd1 Eftud2 LOC100364748 Snrpd2 Snrpd3 Rbm5 Tra2b Sf3b2 Sf3b4 Nupl2 Sf3b3 Pqbp1 Sf3b5 Nupl1 Cstf2 Rbm22 Lsm8 Puf60 Wbp11 Lsm7 U2af1l4 Lsm6 Lsm4 Lsm3 Lsm5 Cpsf7 Cpsf2 Cpsf3 Cpsf4 Lsm2 Rbm17 Cstf1 Snrnp200 Cpsf1 Tgs1 Smptb Gpkow Plrg1 Xpo1 LOC679753 Prpf6 Sf3a3 Sf3b1 Prpf8 Prpf4 Nup205 Ddx46 Sf3a1 Prpf31 Ddx42 Bcas2 Prpf3 Sf3a2 Crnkl1 LOC100360750 Syf2 Fus Smndc1 Prcc Rbmx Adarb1 G6pc LOC100359916 Adar Nup155 Snrpa1 Snrnp70 Hbs1l Dcps Lsm1 Nt5c3b Patl1 Ttc37 Edc3 Edc4 Dcp1b Nup153 Tpr Nup54 Pom121 Nup62 LOC100912571 Psmc6 Nup43 Psmb10 Nup133 Psmb8 Rps20 Psmb9 Rps27l Psmb4 Aaas Psmb11 Psmb5 Psmf1 Psmb6 Psmd4 Psmb2 Psmd5 Npap60 Psmd8 Psmd9 Psmb3 Nup35 Psma8 Snrnp25 Zrsr1 Nup37 Zcrb1 Psmd11 Zmat5 Psmd12 Snrnp48 LOC100360573 Rnpc3 Zrsr2 Psmd13 Snrnp35 Eif4g1 Psmd14 Pdcd7 Rps4x LOC100359951 Rpl30 LOC100359593 Wdr61 Rpl4 LOC100359503 Rplp0 LOC100362640 Rpl6 Rpl13a Rpl26 Rps3 LOC100363800 Rps15a LOC685963 Rpl32 Rps2 Rps13 Gspt1 Pnrc2 Rps12 Pabpc2 Pabpc6 LOC100911372 Rplp1 Rpl39 LOC100361854 LOC684988 Rpl38 Gspt2 LOC103689992 Rpl22 Rps5 Psmc3 Rpl23 Rps7 Rpl10l Rps6 Smg8 Upf1 Rpl15 RGD1563300 Rpl19 Rpl10a Eif4a2 Smg9 LOC100362830 Ranbp2 LOC690468 Rpl29 Eif4a1 Smg7 LOC100363012 LOC680559 Smg6 Smg5 Rpl39l LOC100362149 Rpl41 LOC100912182 LOC100360057 Upf3a Rpl36al Etf1 Rpl13 Rpl3l Rpl36a Ywhaz Ywhab Khsrp Anp32a Tnfsf13 Gtf2f1 Gtf2f2 Ddx5 Prkcd Rps16 LOC100911431 Pabpc1 Rps18 LOC100360679 Rps15 Eif4b Rps3a Psmc5 Psma1 Psma4 Psmc1 Psma3 Psmc4 Psma6 Ppp2r2a Psme1 Psme2 SYNTHESIS OF DOLICHYL-PHOSPHATE MANNOSE%REACTOME DATABASE ID RELEASE 66%10145103 Synthesis of dolichyl-phosphate mannose Dpm3 Dpm2 Dpm1 LOC100910177 RNA POLYMERASE III TRANSCRIPTION INITIATION%REACTOME%R-RNO-76046.1 RNA Polymerase III Transcription Initiation Bdp1 Polr3d Snapc3 Snapc4 Polr3c Polr3a Polr3e Polr3b RGD1565904 Polr3h Polr2h Polr3k Polr2e Polr2f Polr1c Polr3g Polr2k Polr3f Gtf3c6 Gtf3c5 LOC100912534 Gtf3c1 Gtf3c3 Gtf3c4 Polr3gl Brf1 Brf2 Pou2f1 Gtf3a Snapc5 Snapc2 Tbp ADENOSINE P1 RECEPTORS%REACTOME%R-RNO-417973.1 Adenosine P1 receptors Adora3 Adora2a Adora2b LOC100911796 LOC100363178 Adora1 LOC100365814 WAX BIOSYNTHESIS%REACTOME%R-RNO-8848584.1 Wax biosynthesis Awat1 Awat2 Far2 Far1 ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 66%10145451 Acetylcholine Neurotransmitter Release Cycle Chat Rab3a Rims1 Stx1a Cplx1 Syt1 Vamp2 Stxbp1 Ppfia1 Ppfia2 Ppfia3 Ppfia4 Bzrap1 Slc5a7 TRAIL SIGNALING%REACTOME%R-RNO-75158.1 TRAIL signaling Cflar Fadd Tnfsf10 Casp8 DIGESTION%REACTOME DATABASE ID RELEASE 66%10145278 Digestion Pir Amy2a3 Pnliprp1 Chia RGD1309110 Pnliprp2 Alpp Alpi Pnlip Amy1a Chit1 Guca2b Guca2a Lct Si Chi3l3 Gucy2c Alppl2 Lipf Clps CELLULAR SENESCENCE%REACTOME%R-RNO-2559583.1 Cellular Senescence Mdm2 Rad50 Ccna2 Ccne2 Ccna1 Ccne1 Atm Cdk2 Mapkapk5 Nbn Mre11a Ube2d1 Cdk4 Jun Phc1 Phc2 Anapc7 Cdc26 Mapk9 Cdc27 Mapk8 Cdc23 Fos Mapk7 Ube2c Cdkn1a Cdkn1b Txn1 Anapc16 Cdc16 Mapkapk3 Id1 Anapc4 Map4k4 Anapc2 Mapkapk2 Anapc1 Mapk1 Mapk14 Mapk11 Mapk10 Map2k7 Asf1a Map2k6 Ets1 Map2k4 Ep400 Ets2 Tnik LOC100911837 Mink1 Map3k5 Rps6ka2 Rps6ka1 Rps6ka3 Erf Ubn1 LOC100912585 Anapc11 Cabin1 Anapc15 Anapc10 Fzr1 Hira Tinf2 Hist1h2bo Scmh1 Hist1h2bcl1 Hist2h3c2 Cbx4 Cbx2 Hist1h2bk Cbx8 H3f3b Cbx6 Bmi1 Rnf2 Kdm6b Ring1 Phc3 Cdkn2b Terf2ip Cdkn2c Cdk6 Eed LOC100910200 H2afx Hist1h4b LOC684841 Hist1h2bh Acd LOC100912290 Rbbp7 Pot1b Hist1h2ail1 Hist1h4m LOC102549173 LOC103690002 Ehmt2 LOC100910152 Ehmt1 Pot1 LOC100912338 Hist1h3c H2afb3 Hist1h3f Hist2h4 LOC684819 Hist1h3a H2afj Hist2h2aa3 Hist1h2bq Hist2h2aa2 LOC100364835 LOC684762 Terf1 Terf2 LOC100910954 Mdm4 Hist1h2bg Ezh2 LOC680097 LOC684797 LOC100912418 Hist1h2ba Hist3h2bb G ALPHA (S) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 66%10145517 G alpha (s) signalling events Olr1442 Olr1443 Olr1548 Olr80 Olr1440 Olr1547 Pde4a Pde4d Pde4c Olr1436 Ptgir Olr1569 Olr1567 Olr1421 Olr1568 Olr1565 Olr1566 Olr1538 LOC100912374 Olr1539 Olr1437 Olr1439 Olr1433 Olr1434 Olr1435 LOC103690304 Olr83 LOC100912370 Olr1533 Olr1432 Olr1535 Olr1537 Olr1536 Olr81 Olr1449 Olr1542 Olr1541 Olr1540 Olr1445 LOC103693022 LOC100912463 Mc3r Pde1b Mc4r Rln3 Mc2r Gng10 Nps Pde3a Pde2a Cyct Pde10a Pde11a Gphb5 Gpha2 Fshr Tshr Lhcgr LOC100909513 LOC100360745 Olr1600 Olr1605 Olr1405 Olr1601 Olr1407 Olr1404 Olr1406 LOC100910837 Olr1368 Olr1369 Olr226 LOC100911348 Olr229 Olr227 Olr1602 LOC684170 LOC103692138 Lhb Olr1504 Olr233 Olr428 Olr232 Olr427 Olr1505 Olr234 LOC100911377 Olr1400 LOC100911376 Olr231 Ptgdr Olr425 Olr1501 Olr230 Olr208 Olr1202 Olr244 LOC103693685 Olr1519 Olr203 Olr411 Olr209 Olr1007 Olr1006 LOC100911223 Olr237 Olr434 Olr1306 Olr442 Olr441 Olr113 Olr210 Olr1520 Olr114 Olr1523 Olr218 Olr1522 Olr1521 Olr206 Olr1118 Olr204 Olr205 LOC100911398 Tshb Ptger2 Cga Olr1115 Olr1117 Pde7a Olr1734 Olr1340 Olr485 Olr486 Olr16 Mc5r Olr1735 LOC100911043 Olr1737 Gnal Rxfp1 Olr14 Rxfp2 Olr1736 Olr488 Insl3 Olr484 Pde7b Olr1730 LOC100912515 Olr1627 Olr491 Olr1626 Olr490 Olr1621 LOC100912408 Olr1625 Olr1624 Olr200 Olr339 Olr1345 Olr338 Olr1343 Olr202 Olr1344 Olr1341 Olr1356 Taar9 LOC100912605 LOC100911849 Hrh2 Fshb LOC100910199 Taar6 Olr346 Taar5 Taar2 Olr1214 Olr450 Olr499 Olr496 LOC100912505 Olr493 Olr1606 Olr1607 Olr1749 Olr1608 Olr1362 Olr459 Olr458 Olr1361 Adora2a Olr1366 Adora2b Olr1364 Olr360 Olr462 Olr1611 Olr1610 Olr1358 Olr1612 Olr20 Olr24 Olr23 Olr1456 LOC100912431 Olr1597 Olr1593 Olr1592 Olr1450 Olr1452 Olr1598 Olr1454 LOC100909966 LOC100365887 LOC100912159 Olr1654 LOC103693822 Olr30 Olr32 Olr34 Olr331 Olr332 Olr1643 Olr334 Olr330 Olr1642 Olr1644 Olr1645 Olr473 Olr470 Olr1744 Olr1641 Olr1743 Olr1746 Olr472 Olr1640 Pde8b Olr477 Olr475 Pde8a LOC100911479 Olr1235 Olr1738 LOC103690286 Olr1231 Olr329 Or7e24 LOC103690280 Olr326 Olr325 Olr1339 Olr1639 Olr13 Olr12 Olr1637 Olr1638 Olr340 Olr341 LOC102555599 Olr1635 Olr1630 Olr1631 Olr1632 Olr1633 Olr1423 Olr1560 Olr63 LOC100912684 Olr1424 Olr1564 Olr1425 Olr1422 Olr1558 Olr1559 LOC684179 Olr1555 Ptgdrl Olr67 Olr68 Olr69 Olr1416 Olr70 Olr1418 Olr1417 Olr1551 Olr1557 Olr1553 LOC686967 Olr77 LOC100909611 Olr1693 Rtp4 Olr74 RGD1562400 Olr78 Olr75 Olr1583 Olr1589 Olr1488 LOC100912420 Olr1582 LOC100909993 Rtp3 Rtp2 Olr1475 Olr1470 LOC687110 Olr1576 Olr49 Olr46 Olr1588 Olr48 Olr1467 Arrb1 Olr1468 Olr1469 Olr50 Arrb2 Olr51 Olr59 Olr1671 Olr1471 Olr1667 Olr29 LOC100909831 Adrbk1 Olr27 Olr25 Olr1462 LOC100912540 LOC100911586 Gpr39 Olr663 Olr660 Olr561 Olr1024 Olr560 LOC100910009 Olr158 Olr557 LOC100910335 Olr164 Olr659 Olr160 Olr657 Olr662 Olr664 Olr1868 Olr1199 Gpr27 Olr653 LOC100910402 Olr651 Olr650 Olr294 LOC100911909 Olr544 Olr1197 Olr1196 Olr1195 Olr1194 Olr1198 LOC100910409 Olr1128 LOC100911893 LOC100910928 Olr323 Olr119 Olr1126 LOC100912097 Olr1125 Olr420 Olr217 Olr1121 Olr1122 Olr1129 Olr322 Gpr84 Olr214 Olr215 Olr414 Olr1512 Olr1513 Olr416 Olr556 Gpr150 Olr1511 Olr413 Olr1517 Olr319 Olr120 Olr321 Olr1514 LOC100911380 Olr417 Olr418 LOC100910041 Olr259 Olr1163 Olr1166 LOC684208 Olr127 Pomc Olr530 Olr126 Olr931 Olr674 Olr129 Olr532 Olr1174 Olr670 Gpr45 Olr675 Olr892 Olr247 Olr1156 Olr190 Olr194 Olr267 LOC500460 Olr192 Olr262 Olr1064 Olr896 Olr263 LOC100910049 Olr698 Olr799 LOC103693566 Olr922 Olr684 Olr1186 LOC100910120 Olr536 Olr1185 Olr143 Olr535 Olr140 Olr142 Olr148 LOC100910648 Olr1016 Olr149 Olr951 Gpr25 LOC100910224 Olr666 Olr1179 Olr522 Olr130 Olr527 Olr526 LOC100910637 Olr132 LOC100910010 Olr529 Olr528 Olr139 Olr137 Olr686 Olr1877 LOC100910559 Olr186 Olr189 Olr1081 Olr1147 Olr188 Olr584 Olr1082 Olr281 Olr382 Olr384 Olr1086 Olr1087 Olr587 Olr581 Olr282 Olr776 Olr582 Olr777 Olr583 Olr283 Olr962 Gpr15 Olr964 Olr285 Olr286 Olr1135 Olr1132 Olr172 LOC100910051 Olr1130 Olr170 Ghrh Olr198 Ramp3 Olr588 Vipr2 Olr199 Sct Olr1155 Gip Olr597 Gipr Olr1057 Pth1r Olr196 Iapp LOC100911805 Crhr2 Grk6 Gcgr Olr252 Olr1052 Crhr1 Olr598 Glp2r Olr695 Pth2 Olr251 Ramp2 Olr250 Ghrhr Olr697 LOC100910999 Olr590 Grk5 LOC100910445 Olr1143 Olr180 Olr690 Olr1144 Olr783 Olr379 Olr1142 LOC100910162 Olr782 Gpr176 LOC100911839 Olr184 Olr845 LOC100910274 Olr847 Olr848 Olr1391 Olr852 Olr1496 LOC686792 LOC100912204 Olr1096 LOC100365798 RGD1562066 Olr844 Olr841 Olr744 Olr745 LOC100909686 Olr878 LOC100910597 Olr1376 Olr850 Olr851 LOC100909578 LOC100909683 LOC100910294 LOC687097 LOC100909884 LOC100909885 Olr1374 Olr1372 Olr1373 Olr1370 Olr1071 Olr569 Olr174 Olr175 Olr774 Olr176 Htr4 Olr1274 Olr1076 LOC100910876 Olr575 Olr1075 Olr373 Olr1275 Olr1070 Olr1137 Htr7 Olr375 Olr377 Olr378 Olr372 Olr1079 Olr374 Olr1073 Olr854 Olr853 Olr279 LOC100911035 Olr765 Olr278 Olr376 Htr6 LOC100910256 Olr834 Olr641 LOC100909438 LOC100909796 Gpr83 LOC690821 LOC100912217 Olr601 Olr602 Olr604 Olr709 Olr609 Olr607 Olr608 LOC687088 Olfr873 Olr806 LOC686677 Olr702 Olr808 Olr705 Olr704 Olr807 Olr519 Olr614 Olr718 Olr811 Olr514 Olr515 Olr611 Olr610 Olr819 Olr716 Olr713 Olr816 Olr717 Olr714 Olr813 Olr812 Olr1382 Olr1381 Olr1384 Adrb3 Olr1383 Olr711 LOC100912327 Olr818 Olr712 Olr724 Olr1380 Reep6 LOC684683 Olr720 Olr722 LOC686660 Olr1385 Olr1378 Reep1 Reep5 Olr729 Reep4 Reep3 Reep2 Olr725 Pth Sctr Adm Calcb Vip Calca Ramp1 Adcyap1r1 Adcyap1 Pth2r Adm2 Crh Gnb3 Gnb5 Gnb2 Gnb1 Gng13 Gng12 Gng11 LOC100912034 Gnb4 LOC687065 Glp1r Drd5 Gcg Gng4 Drd1 Gngt2 Gng5 LOC684539 Olr820 Gngt1 Gng8 Olr821 Gng3 Olr823 Avp Pde3b Adrb2 TNFR1-MEDIATED CERAMIDE PRODUCTION%REACTOME DATABASE ID RELEASE 66%10146089 TNFR1-mediated ceramide production Nsmaf Smpd2 Smpd3 Tnf SIGNALING BY RETINOIC ACID%REACTOME DATABASE ID RELEASE 66%10145381 Signaling by Retinoic Acid Dhrs3 Cyp26c1 Crabp1 Rarg Rxra Pdhb Sdr16c5 Pdk3 Pdk4 Pdk1 Pdk2 LOC100365902 Dhrs4 Rdh14 Pdha2 Rdh13 Aldh8a1 Pdha1 Pdhx Ppard Fabp5 Pdha1l1 Dhrs9 Rdh10 Cpt1b Rdh16 Akr1c2 LOC100365958 Rxrg Cpt1a Akr1c12l1 Akr1c3 Dlat Rara Akr1c19 Rarb Rdh11 Cyp26a1 Adh6 Akr1c13 Akr1c14 RGD1564865 Akr1c12 Cyp26b1 Akr1c1 Dld DIMERIZATION OF PROCASPASE-8%REACTOME%R-RNO-69416.1 Dimerization of procaspase-8 Faslg Traf2 Cflar Fadd Ripk1 Tradd Tnfsf10 Casp8 Fas REGULATION OF GAP JUNCTION ACTIVITY%REACTOME DATABASE ID RELEASE 66%10145308 Regulation of gap junction activity Gja1 Src PROLONGED ERK ACTIVATION EVENTS%REACTOME DATABASE ID RELEASE 66%10145181 Prolonged ERK activation events Ntrk1 Ngf Kidins220 Crk Rap1a Crkl Frs2 Rapgef1 LOC100911248 RELEASE OF APOPTOTIC FACTORS FROM THE MITOCHONDRIA%REACTOME DATABASE ID RELEASE 66%10145018 Release of apoptotic factors from the mitochondria Diablo Bax Bak1 LOC100360940 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE%REACTOME%R-RNO-1660499.1 Synthesis of PIPs at the plasma membrane Pik3r5 Bmx Pten Mtmr9 Mtmr6 Pik3r3 Pik3r1 Pik3r6 Pik3r2 Ptpn13 Synj1 Inpp4a Plekha4 Plekha3 Inpp4b Inpp5d Plekha5 Mtmr14 Plekha8 Synj2 Plekha1 Pik3cd Mtmr3 Pik3cg Inpp5j Mtmr1 Pip5k1c Rufy1 Pi4k2a Pip5k1b Pip5k1a Pik3cb Pik3c2a Ocrl Pip4k2b Pik3c2b Pip4k2c Pi4k2b Pik3c2g TRANSPORT AND SYNTHESIS OF PAPS%REACTOME%R-RNO-174362.1 Transport and synthesis of PAPS Slc35b2 Slc26a2 Slc35b3 Slc26a1 Papss2 Papss1 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING%REACTOME DATABASE ID RELEASE 66%10145207 Downregulation of TGF-beta receptor signaling Smad3 Smad2 Strap Pmepa1 Tgfbr1 Tgfb1 Bambi Tgfbr2 Mtmr4 Stub1 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI)%REACTOME%R-RNO-162710.1 Synthesis of glycosylphosphatidylinositol (GPI) LOC100910143 LOC100910849 Pigm Pigw Pigl Pigv Pigg Pigy Pigx Pigh Pign Pigq Pigc Pigp Pigb Piga Dpm2 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS%REACTOME%R-RNO-997272.1 Inhibition of voltage gated Ca2+ channels via Gbeta gamma subunits Kcnj4 Kcnj6 Kcnj16 Gnb3 Gnb2 Gnb1 Gng12 Kcnj2 Kcnj3 Kcnj15 Kcnj9 Kcnj5 Gng4 Gngt2 Gabbr1 Gng5 Kcnj12 Gngt1 Gng10 Gng8 Gabbr2 Gng3 PROTON-COUPLED NEUTRAL AMINO ACID TRANSPORTERS%REACTOME DATABASE ID RELEASE 66%10145510 Proton-coupled neutral amino acid transporters Slc36a2 Slc36a1 ERYTHROPOIETIN ACTIVATES PHOSPHOINOSITIDE-3-KINASE (PI3K)%REACTOME DATABASE ID RELEASE 66%10146294 Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Pik3r5 Gab1 Pik3cb Pik3r1 Irs2 Lyn Epor Pik3cd Pik3cg Epo METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS%REACTOME DATABASE ID RELEASE 66%10145925 Metabolism of Angiotensinogen to Angiotensins Cpb2 Cpb1 Ren Agt Ace LOC691670 Ctsz Atp6ap2 Ctsd Gzmf Ace3 Cpa3 Ctsg Npepo Gzmn LOC100910060 Cma1 Mme ION CHANNEL TRANSPORT%REACTOME DATABASE ID RELEASE 66%10145600 Ion channel transport Atp6v1d Trpc4ap Raf1 Sri Atp6v1g1 Atp6v1g2 Atp6v0a4 Atp6v1b2 Atp6v0a2 Atp6v1h Atp6v1f Atp8a1 Trpm2 Atp6v0c Pdzd11 Atp6v0d1 Atp6v1c2 Atp6v0d2 Vps25 Atp6v1a Atp6v0e2 Atp6v0e1 Atp6v1g3 Atp6v1e1 Atp6v1e2 Atp6v1c1 Ano6 Scnn1b Camk2g Best1 Best3 Best2 Atp2b4 Scnn1g Tpcn2 Scnn1a Clcn4 Unc79 Atp2b2 Atp2b1 Slc9b1 Camk2d Clcn7 Clcn6 Clcn5 Camk2a Ano10 Wwp1 Ano3 Clic2 Asic4 Asic5 Ano1 Trdn Atp7a Atp2a2 Atp7b Best4 Pln Clcnkb Asic3 Atp2a3 Slc9b2 Slc17a3 Fxyd2 Sgk2 Fxyd3 Fxyd4 Sgk3 Atp10b Clcn1 LOC100912455 Wnk4 Atp11c Tcirg1 Sln Ostm1 Wnk1 Wnk2 Wnk3 Atp9b Clcn2 Fxyd6 Atp6ap1 Atp10d Fxyd7 Stom Atp1b3 Atp1b2 Atp6v0a1 Clca4 Atp1b1 Trpv4 Fkbp1b Trpv5 Atp8b3 Trpv6 Atp8b2 Atp8b1 Ano9 Ryr2 Ano4 Ano7 Atp2c2 Clca2 Atp2c1 Sgk1 Atp11a Stoml3 Mcoln2 Atp12a Mcoln3 Atp13a5 Trpv1 Atp13a4 Trpc5 Atp13a2 Trpm6 Ttyh1 Trpm3 Ttyh2 Trpm8 LOC100361584 Trpm5 Atp8a2 Trpc3 Atp1a4 Trpc7 Atp4b Trpm1 Atp4a Trpc4 Bsnd Mcoln1 Atp1a1 Trpc6 Atp1a2 Trpv3 Atp13a1 Atp1a3 Trpa1 CREB3 FACTORS ACTIVATE GENES%REACTOME DATABASE ID RELEASE 66%10146248 CREB3 factors activate genes Creb3l3 Crebrf Creb3 Mbtps1 Mbtps2 ORC1 REMOVAL FROM CHROMATIN%REACTOME%R-RNO-68949.1 Orc1 removal from chromatin Psmc6 Psmb10 Psmb8 Psmb9 Psmb4 Psmb11 Psmb5 Psmf1 Psmb6 Psmd4 Psmb2 Rbx1 Cul1 Psmd5 Psmd8 Psmd9 Psmb3 Psma8 Psmd11 Psmd12 Ccna2 Ccna1 Psmd13 Psmd14 Mcm2 Mcm4 Mcm3 Cdk2 Mcm5 Mcm6 Psmc3 Mcm8 Mcm7 Orc4 Orc5 Orc6 Orc1 Orc2 Orc3 Cdc6 G6pc Psmb7 Psmb1 Skp1 Psma5 Skp2 Cdt1 Psma2 Psmc5 Psmd2 Psma1 Psma4 Psmc1 Psma3 Psmc4 Psmc2 Psma6 Psme1 Psmd1 Psme2 Psmd7 Psmd3 Psmd6 SIGNALING BY FGFR2%REACTOME DATABASE ID RELEASE 66%10145256 Signaling by FGFR2 Frs3 RGD1565904 Fgf23 Fgf22 Polr2g Fgf4 Polr2h Fgf1 Polr2e Fgf3 Polr2f Polr2j Fgf6 Polr2k Fgf5 Polr2d Polr2i Polr2b Polr2c Polr2a Fgf20 Gab1 Mknk1 Gtf2f1 Esrp2 LOC100912534 Gtf2f2 Esrp1 Fgf16 Rbfox2 Fgf17 Tia1 Fgf10 Tial1 Fgfbp3 Fgf9 Fgfbp1 Fgfr2 Fgf2 Fgf7 Spry2 Cbl Fgf8 Fgfr3 Fgfr1 Fgfr4 Fgf19 Frs2 Kras Src Pik3r1 Hnrnph1 Ppp2cb Ppp2ca Ppp2r1a LOC100911822 Ncbp2 Ncbp1 Mapk1 Ptpn11 Plcg1 Hras Nras Hnrnpm Hnrnpf Sos1 Shc1 Grb2 AMINE OXIDASE REACTIONS%REACTOME DATABASE ID RELEASE 66%10145056 Amine Oxidase reactions Maob Smox Maoa RGD1564480 Paox TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION%REACTOME%R-RNO-948021.1 Transport to the Golgi and subsequent modification Mgat2 Mgat5 Areg Stx5 Sec24a Bet1 Sec24b Arf5 Dync1li2 Copa Cnih1 Sec24d Mgat3 Mgat1 Arf4 Dync1i2 Lhb Ctage5 Man1c1 Gbf1 Man1a1 Cnih3 Cnih2 Tgfa Cog4 Cog6 Cog8 Cog3 Man2a1 Fut8 Cog1 Man2a2 Cog2 Sec23ip Mgat4b Lman1l Mgat4a Cog7 LOC102555167 Dynll2 Copz2 Dync1i1 Copz1 Col7a1 Lman2 Ykt6 F8 Sec16a Sec24c Scfd1 Sec16b Lman1 Cga Trappc2 Tmed7 Tmed3 Trappc5 Tmed2 Napg Napb Copb1 Napa Chst8 Tmed9 Tfg Nsf Trappc3 LOC100910318 Kdelr1 Tbc1d20 Capza2 Capza3 Arcn1 Kdelr2 St3gal4 Ppp6r3 Trappc1 Ppp6r1 Kdelr3 Trappc10 LOC100910557 Sptan1 Ppp6c Manea Actr10 Trappc2l Cd59 Dync1h1 Dync1li1 Trappc6a Trappc6b B4galt1 Copg1 Ankrd28 B4galt3 Sec13 Dctn5 B4galt2 Sar1b Dctn6 B4galt6 B4galt4 B4galt5 Ins1 Ins2 Rab1b Rab1a Dctn4 Tmem115 Folr1 Arfgap2 Dctn1 Ank1 Ctsc Dctn2 Uso1 Golgb1 Arfgap3 Gorasp1 Ctsz Arfgap1 Dctn3 Spta1 Mcfd2 Preb Chst10 St8sia3 Capzb Sec22b Cope Sec23a Sptbn1 Sec31a Sec22a Stx17 Csnk1d St6gal1 Man1a2 Gosr2 Actr1a LOC100363782 Gosr1 Tmed10 L1CAM INTERACTIONS%REACTOME DATABASE ID RELEASE 66%10144965 L1CAM interactions Ank1 Src Gap43 Rdx Egfr Nrp1 Kif4a Ranbp9 Sptan1 Rac1 Cltc L1cam Csnk2a2 Ezr Clta Nfasc Dnm2 Spta1 Csnk2a1 Ap2s1 Vav2 Ap2a1 Ap2m1 Ap2a2 Csnk2b Dnm1 Dnm3 Sdcbp Ncam1 Sptbn1 Lypla2 Msn Fgfr1 Mapk1 Dpysl2 Sh3gl2 Nrcam Pak1 Itga2b Map2k2 PROLACTIN RECEPTOR SIGNALING%REACTOME DATABASE ID RELEASE 66%10145783 Prolactin receptor signaling Prl Skp1 Sh2b1 Gh1 Ghr Btrc Rbx1 Cul1 ACETYLATION%REACTOME DATABASE ID RELEASE 66%10145083 Acetylation Nat1 Nat2 Nat3 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII%REACTOME DATABASE ID RELEASE 66%10145658 CREB phosphorylation through the activation of CaMKII Grin2d Camk2g Grin2b Grin1 Nefl Dlg1 Dlg2 Dlg3 Camk2d Actn2 Camk2a Lrrc7 Creb1 Dlg4 FORMATION OF XYLULOSE-5-PHOSPHATE%REACTOME DATABASE ID RELEASE 66%10146116 Formation of xylulose-5-phosphate Xylb Akr1a1 Sord Cryl1 Dcxr BETA DEFENSINS%REACTOME DATABASE ID RELEASE 66%10145858 Beta defensins Defb26 Defb28 Ccr6 Defb30 Defb18 Defb36 Defb14 Defb12 Defb29 Defb49 Defb25 Tlr10 Defb43 Defb44 Defb13 Defb41 Defb1 Defb22 Defb23 Defb20 Defb21 Tlr2 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY%REACTOME%R-RNO-399721.1 Glutamate binding, activation of AMPA receptors and synaptic plasticity Ap2a2 Camk2g Mdm2 Dlg1 Gria3 Gria4 Grip1 Grip2 Camk2d Pick1 Camk2a Cacng8 Akap5 Prkca Prkcb Nsf Ap2s1 Cacng2 Cacng3 Cacng4 Ap2a1 Myo6 Dlg4 Ap2m1 STRIATED MUSCLE CONTRACTION%REACTOME%R-RNO-390522.1 Striated Muscle Contraction Tnni1 Tnnt3 Tnni2 Tnnt2 Tnni3 Actn2 Tnnt1 Tmod2 Tnnc2 Actn3 Mybpc3 Des Tmod4 Tmod3 Vim Tmod1 Tpm4 Tpm2 Myl3 Myl4 Mybpc2 Tpm3 Tnnc1 Myh6 Dmd Myl1 ABC TRANSPORTERS IN LIPID HOMEOSTASIS%REACTOME DATABASE ID RELEASE 66%10145461 ABC transporters in lipid homeostasis Abcd2 Abcd3 Abcd1 Pex3 Abca3 Abca2 Apoa1 Abca6 Abca5 Abcg4 Abcg1 Abca7 Abcg8 Abcg5 RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF MYELOID CELLS%REACTOME DATABASE ID RELEASE 66%10146266 RUNX1 regulates transcription of genes involved in differentiation of myeloid cells Cbfb Crebbp Runx1 ESR-MEDIATED SIGNALING%REACTOME DATABASE ID RELEASE 66%10145830 ESR-mediated signaling Ppp5c Yy1 Esr2 RGD1565904 Polr2g Polr2h Polr2e Polr2f Polr2j Polr2k Polr2d Polr2i Kdm1a Polr2b Polr2c Polr2a LOC100912534 Sp1 Hsp90ab1 Cdk9 Hdac1 Jun LOC100911822 Fos Mapk1 Fkbp5 Med1 Atf2 Ppid Ppidl1 Cited1 Hist1h2bo Hist1h2bcl1 Nr5a2 Gtf2f1 Hist2h3c2 Gtf2f2 Hist1h2bk Kdm4b H3f3b Carm1 Greb1 Usf1 Gtf2a1 Foxa1 LOC103692716 Bmyc Ptges3 Hdac1l Prmt1 Zfp217 Ptges3l1 Esr1 Pou2f1 Cbfb Tle3 Gata3 Fkbp4 Ddx5 Erbb4 Crebbp Nrip1 Pgr Ncoa1 Tbp Runx1 LOC100910200 H2afx Hist1h4b LOC684841 Hist1h2bh LOC100912290 Hist1h2ail1 Hist1h4m LOC102549173 LOC103690002 LOC100910152 LOC100912338 Hist1h3c H2afb3 Hist1h3f Hist2h4 LOC684819 Hist1h3a H2afj Hist2h2aa3 Hist1h2bq Hist2h2aa2 LOC100364835 LOC684762 Ncoa2 Hist1h2bg LOC680097 LOC684797 LOC100912418 Hist1h2ba Hist3h2bb G ALPHA (Q) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 66%10145036 G alpha (q) signalling events Gpr39 Npff Plcb1 Npffr2 RGD1560028 Hcrt Npffr1 Qrfp LOC100909783 Egfr Plcb3 Ffar1 Hbegf Gnaq Gna11 Gna14 Ghrl Gna15 Plcb4 Kng1l1 F2rl3 Hcrtr1 Qrfpr F2r F2 Hcrtr2 F2rl2 Uts2 Ntsr2 Trhr Nmu Ntsr1 Pik3r3 Anxa1 Pmch Htr2c Htr2a Dgkk Dgki Tac3 Kiss1 Htr2b Tac1 Lpar5 Edn2 Ednra Ptafr Ednrb Grp Edn3 Grpr Ffar4 Lpar1 Lpar3 Edn1 Lpar2 F2rl1 Oxtr Oxt Nmb LOC100909648 Avpr1b Xcl1 Avpr1a Ccl9 Ccl6 Dgkg Gpr4 Dgkd Dgke Agt Dgka Mapk7 Dgkb Gpr132 Gnb3 Gpr143 Gnb5 Rgs3 Opn4 Gnb2 Rgs19 Gnb1 Rgs2 Gng13 Rgs18 Gng12 Hrh1 Gng11 Mapk1 Chrm1 Chrm5 Ghsr Itpr1 Arhgef25 Dgkz Creb1 LOC100909523 Itpr3 Dgkq Nts Prkca LOC100912034 Dgkh Gnb4 Cysltr2 Gcg Cysltr1 Gng4 Gpr65 Gngt2 Gpr68 Gng5 Ptgfr Gngt1 Prkch Gng8 Ptger1 Gng3 Chrm3 Agtr1b Agtr1a Prokr2 Casr Grm1 Cckar Uts2r Prokr1 NMS Gprc6a Rps6ka2 Xcr1 Rps6ka1 App Rps6ka3 LOC100912585 Mgll Ltb4r Ffar2 Abhd12 Ffar3 Daglb Ltb4r2 Abhd6 Avp Dagla Brs3 Prkcq Prok2 Gcgr Prok1 Mchr1 Cck Tacr3 Tacr2 Bdkrb1 Bdkrb2 Trh Gng10 Nps P2ry6 Prkcd Lpar6 P2ry1 Kras Pik3r1 Gpr17 Pik3r2 Lpar4 Adra1a Tbxa2r Kalrn Adra1d Kng1 P2ry2 P2ry10 Kng2 Gnrhr Gnrh1 Cckbr Gast Uts2b Nmur2 Trpc3 Trpc7 Hras Nras Adrbk1 Sos1 Trpc6 Grb2 Tacr1 PI3K EVENTS IN ERBB4 SIGNALING%REACTOME%R-RNO-1250342.1 PI3K events in ERBB4 signaling Ereg Nrg1 Btc Pik3r1 Nrg3 Erbb4 Hbegf Nrg2 Nrg4 CGMP EFFECTS%REACTOME%R-RNO-418457.1 cGMP effects Pde1b Pde9a Pde5a Pde3b Pde3a Itpr1 Prkg2 Pde2a Cyct Mrvi1 Pde10a Pde11a INTERACTION BETWEEN PHLDA1 AND AURKA%REACTOME DATABASE ID RELEASE 66%10146219 Interaction between PHLDA1 and AURKA Phlda1 Aurka G-PROTEIN MEDIATED EVENTS%REACTOME%R-RNO-112040.1 G-protein mediated events Prkcd Plcb1 Gnai3 Gnal Plcb3 Gnat3 Pla2g4a Gnao1 Adcy3 Prkar2b Prkar2a Gnat2 Gnaz Pde1b Adcy8 Adcy9 Adcy5 Adcy4 Gnai2 Adcy7 Adcy6 Prkar1b Prkar1a Plcb4 Mapk1 Prkaca Prkacb Gnat1 Prkca Camk4 Adrbk1 Gnai1 ERBB2 REGULATES CELL MOTILITY%REACTOME DATABASE ID RELEASE 66%10146156 ERBB2 Regulates Cell Motility Ereg Nrg1 Btc LOC102552659 Erbb3 Erbb2 Nrg3 Egfr Hbegf Nrg4 Diaph1 Memo1 Rhoa Erbb4 Nrg2 S PHASE%REACTOME%R-RNO-69242.1 S Phase Rfc1 Psmc6 Rfc2 Psmb10 Psmb8 Pole2 Psmb9 Pole4 Psmb4 Psmb11 Psmb5 Psmf1 Psmb6 Psmd4 Mnat1 Psmb2 Rbx1 Psmd5 LOC100910252 Psmd8 Stag1 Psmd9 Psmb3 Psma8 Psmd11 Psmd12 Pds5b Prim2 Ccna2 Pds5a Ccne2 Pola2 Ccna1 Psmd13 Cdca5 Prim1 Ccne1 Rad21 Psmd14 Smc1a Stag2 Smc3 Esco2 Mcm2 Mcm4 Mcm3 Cdk2 Mcm5 Esco1 Rpa3 Mcm6 Pole Pcna Psmc3 Ccnh Mcm8 Mcm7 Orc4 Orc5 Orc6 Orc1 Orc2 Orc3 Rfc5 Rfc4 Cdc6 Rfc3 Ube2d1 Cdk4 Akt1 Rpa1 Ccnd1 Rpa2 Skp1 Lig1 Anapc7 Cdc26 Cdc27 Cdc23 Ube2c Skp2 Cdkn1a Cdkn1b Anapc16 Cdc16 Anapc4 Anapc2 Anapc1 Akt3 Slc25a16 Fen1 Cul1 Ptk6 Anapc11 Anapc15 Anapc10 Fzr1 Cks1l Cables1 Cks1b Akt2 G6pc Rb1 Psmb7 Psmb1 Gins3 Gins4 Gins1 Gins2 Psma5 LOC100911727 Cdk7 Cdt1 Pold2 Pold1 Psma2 Pold4 Psmc5 Psma1 Psmd2 Psma4 Cdc25b Psmc1 Cdc25a Psma3 Wee1 Psmc4 Psma6 Psmc2 Psme1 Psme2 Psmd1 Psmd7 Psmd3 Psmd6 IL-6-TYPE CYTOKINE RECEPTOR LIGAND INTERACTIONS%REACTOME DATABASE ID RELEASE 66%10145682 IL-6-type cytokine receptor ligand interactions Crlf1 Cntfr Lif Il6st Osm Jak1 Il11ra1 Lifr Clcf1 Il11 Il31ra Ctf1 Cntf Osmr Tyk2 VESICLE-MEDIATED TRANSPORT%REACTOME DATABASE ID RELEASE 66%10145300 Vesicle-mediated transport Kif21a Kif21b Kifc1 Kif3c Racgap1 Kif22 Kif3b Kif23 Kif18b Kifap3 Kif11 Egfr Kif12 Kif4a Kif6 Kif1a Kif1c Dnm2 Kif27 Kif9 Kif13b Cops8 Cops2 Nedd8 Akt1 Cops4 Cops6 Myo6 Cops3 Calr Kif20b Kif16b Kif26a Kif20a Kif26b Kif19 Galnt1 Galnt2 Sparc App Hbb-b1 Cd59 Arf6 Rab3ip Vamp8 Gdi2 Sar1b Stam2 Sh3gl2 Apob Sh3gl1 Apoe Sh3kbp1 Sh3gl3 Stam Rab4a LOC685953 Cd36 Ank1 Ctsc Ctsz Itsn1 Spta1 Dnm1 Dnm3 Sptbn1 Cops7b Cops7a Snap29 Pla2g6 Rab8a Tgfa Alpp Alpi Kif3a Col7a1 F8 Scfd1 Tsc1 Tsc2 Akt3 Pik3c2a Bnip1 Rabgap1 Madd Rin3 Clvs1 Snx18 Chmp2b Chmp2a Use1 Rgp1 Apol2 Hsp90b1 Hip1r Pla2g4a Colec12 LOC100909679 Ulk1 RGD1309808 Scgb3a2 Sbf2 Ap1m2 Cd163 Mvb12b Apol11a Mvb12a Apol3 Hpx Snx5 Stx16 Msr1 LOC100910885 Snx9 Fnbp1l Apol9a Snx2 Chmp4b Stx18 Chmp4c Golga5 Gapvd1 Golga1 Golga4 Dennd3 Acbd3 Sort1 Dnase2 Tbc1d10a Clint1 Tsg101 Tbc1d10b Cbl Yipf6 Ap4s1 Vta1 Hip1 Hps4 Tpd52 LOC100910792 Hps1 Mon1b Mon1a Cyth1 Cyth4 Cyth3 Cyth2 Trip11 Dennd1a Nbas Trappc12 Trappc11 Dennd1b Dctn1 Dctn2 Dctn3 Marco Hba1 Ambp Lrp1 Rab11a LOC287167 Csnk1d Arrb1 Arrb2 Adrbk1 Actr1a Klc1 Sec24a Sec24b Dync1li2 Copa Sec24d Sbf1 Dync1i2 Gja10 Gjd2 Syt1 Vamp2 Man1c1 Gjc1 Klc4 Man1a1 Cenpe Klc2 Klc3 Chmp4bl1 Cog4 Cttn Cog6 Gcc1 Cog8 Amph Cog3 Gja5 Rhobtb3 Pafah1b1 Cpd Cog1 Gja3 Cog2 Gja8 Usp6nl Gja4 Sec23ip Rala LOC100361515 Lman1l Gjb6 Scoc Cog7 Ap1b1 LOC102555167 Gjb2 Stx6 Dynll2 Vps37a Gjb3 Gjb4 Rab39a Vps37d Vps37c Stx4 Dync1i1 Rab11b Vps37b Gjc2 Tbc1d1 Tbc1d2 Ykt6 Tbc1d7 Sec24c Rabepk Gabarap Vps45 Bin1 Ubap1 Tmed7 Vps53 Tmed3 Vps52 Cux1 Tmed2 Ap4e1 Gjd4 Arfip2 Vps54 Rab6b Rab9a Ap4b1 Napg Ap1g2 Napb Ric1 Synj1 Napa Fnbp1 Vps4b Ccz1b Tpd52l1 St5 Snapin Scarb1 Rab3gap2 Tmed9 Dennd6b Dennd6a Apoa1 Ap3b1 Bicd2 Synj2 Vps25 Nsf Bicd1 Chmp5 Alppl2 Chmp7 Golim4 Bloc1s3 Snf8 Vps36 Chmp6 Rab8b Chmp3 Pum1 Arl1 Dennd5a Ap4m1 Bloc1s4 Gabarapl2 Agpat3 Bloc1s1 Bloc1s6 Rab3il1 LOC100910929 Chm Arfrp1 Trappc8 Dennd4a Dennd4b Arcn1 Pacsin2 Rab7b Pacsin3 Tbc1d13 Tbc1d16 Tbc1d15 Tbc1d17 Sytl1 Dennd2a Dennd2d Rab33a Dennd2c Rab33b Trappc13 Ap1s3 Ap1s1 Plin3 Ap1s2 Tbc1d25 Gak Pafah1b3 Tbc1d14 Trappc10 Rab35 Rab36 Ppp6c Trappc2l Rab43 Pip5k1c Rab21 Trappc6a Trappc6b Rab12 Rab13 Ankrd28 Rab32 Sec13 Rab30 Rab38 Rab1b Wasl Rab1a Tmem115 Ocrl Arfgap2 Stab2 Arpc4 Golgb1 Arpc3 Arfgap3 Kif2a Arfgap1 Kif2c Kif2b Kif18a Mcfd2 Preb Capzb Kif5b Kif5a Actr3 Sec31a Stx17 Dvl2 Gosr2 Gosr1 Zw10 Tmed10 Areg Stx5 Ftl1 Bet1 Arf5 Cnih1 Igf2r Arf4 Ctage5 Rab27a Gbf1 Cnih3 Cnih2 Ap2a2 Man2a1 Man2a2 Copz2 Copz1 Lman2 Sec16a Sec16b Lman1 Trappc2 Gja1 Trappc5 Src Rab27b RGD1561661 Rab3a Copb1 Wnt5a Cltc Cltb Rab7a Clta Tfg Fzd4 Ywhah Ywhag Sfn Ap2s1 Ywhaz Ywhab Ap2a1 Ywhaq Ywhae Trappc3 Ap2m1 LOC100910318 Rab5b Kdelr1 Rab5c Tbc1d20 Capza2 Capza3 Rab6a Kdelr2 Gjb1 Rab9b Ppp6r3 Ppp6r1 Trappc1 Kdelr3 Agtr1b Agtr1a Syt11 Aak1 Sgip1 Eps15l1 LOC100909548 Itsn2 Scarb2 LOC100910557 Necap1 Agfg1 Snap91 Ubqln2 Sptan1 Picalm Tgoln2 Ldlr Rab18 Tor1a Ston2 Tfrc RGD1307443 Rab10 Tf Chrm2 Rab14 Necap2 Cd4 Actr10 Tor1b Avp Dab2 Ston1 Dync1h1 Dync1li1 RGD1565355 Copg1 Dctn5 Dctn6 Ins1 Ins2 Dctn4 Folr1 Akt2 Uso1 Gorasp1 Ap1m1 LOC100360087 Txndc5 Actr2 Sec22b Cope Sec23a Sec22a Cd3g Slc2a8 Syt8 Cd3d Syt9 Arpc5 Syt2 Fcho2 Man1a2 Fcho1 M6pr Ldlrap1 Vamp4 Vamp3 Optn LOC100363782 Adrb2 Tbc1d10c Vamp7 Tacr1 Grb2 CONJUGATION OF PHENYLACETATE WITH GLUTAMINE%REACTOME DATABASE ID RELEASE 66%10145246 Conjugation of phenylacetate with glutamine Acsm1 SIGNALING BY FGFR1%REACTOME%R-RNO-5654736.1 Signaling by FGFR1 Src Kras Pik3r1 Frs3 Fgf23 Fgf22 Fgf4 Fgf1 Ppp2cb Fgf3 Ppp2ca Fgf6 Ppp2r1a Fgf5 Flrt1 Flrt2 Fgf20 Gab1 Mknk1 Fgf16 Fgf17 Fgfrl1 Fgf10 Fgf9 Fgfr2 Fgf2 Fgf7 Cbl Spry2 Fgf8 Fgfr3 Fgfr1 Mapk1 Fgfr4 Spred1 Ptpn11 Spred2 Plcg1 Fgf19 Hras Nras Frs2 Sos1 Shc1 Grb2 RNA POLYMERASE I CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 66%10144884 RNA Polymerase I Chain Elongation Gtf2h1 Gtf2h2 Mnat1 RGD1565904 Ubtf Polr1b Taf1d Polr2h Taf1c Cd3eap Polr2e Znrd1 Polr2f Polr1c Polr1a Polr2k Hist1h2bo Hist1h2bcl1 Hist2h3c2 LOC100912534 Hist1h2bk H3f3b Ccnh Gtf2h3 Gtf2h5 Tbp Gtf2h4 LOC100910200 H2afx Hist1h4b LOC684841 Hist1h2bh LOC100912290 Hist1h2ail1 Hist1h4m LOC102549173 LOC103690002 LOC100910152 LOC100912338 Hist1h3c H2afb3 Ercc3 Hist1h3f Hist2h4 LOC684819 Hist1h3a H2afj Hist2h2aa3 Hist1h2bq Hist2h2aa2 Ercc2 LOC100364835 LOC684762 Cdk7 Twistnb Polr1e Hist1h2bg LOC680097 LOC684797 LOC100912418 Hist1h2ba Hist3h2bb INTERLEUKIN-17 SIGNALING%REACTOME%R-RNO-448424.1 Interleukin-17 signaling Map2k7 Ripk2 Map2k6 Dusp3 Map2k4 Map3k8 Dusp4 Traf6 Cul1 Vrk3 Rps6ka2 Rps6ka1 Rps6ka3 Rps6ka5 LOC100912585 Tab1 Dusp7 Dusp6 Atf1 Atf2 Map3k7 Irak2 LOC100910771 Ube2n Il17c Il17a Jun Il17rc Ppp2cb Ppp2ca Skp1 Ppp2r1a Il25 Il17rb Il17ra Il17re Nfkb1 Mapk9 Mapk8 Fos Mapk7 Fbxw11 Chuk Ppp2r1b Mapkapk3 Btrc Mapkapk2 Mapk1 LOC100362142 Nod1 Nod2 Creb1 Tab2 Tab3 LOC100912618 Ube2v1 Ikbkb Mapk14 Tnip2 Mapk11 Mapk10 HDMS DEMETHYLATE HISTONES%REACTOME DATABASE ID RELEASE 66%10145998 HDMs demethylate histones Jmjd6 Hist1h4b LOC684841 LOC100912290 Hist1h2ail1 Hist1h4m LOC102549173 Hist1h3c Hist1h3f Hist2h4 Kdm2a LOC684819 Hist1h3a Kdm1b Kdm1a RGD1310212 LOC684762 Hist2h3c2 Kdm4b Kdm4a Kdm4d Kdm5a Kdm6b Kdm5d Kdm4dl1 Kdm8 Kdm3b Kdm3a LOC680097 LOC100912418 RNA POLYMERASE I TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 66%10144850 RNA Polymerase I Transcription Initiation Gtf2h1 Gtf2h2 Rbbp7 Ehmt2 Mnat1 RGD1565904 Ubtf Polr1b Hdac1 Ercc3 Taf1d Ercc6 Polr2h Taf1c Cd3eap Polr2e Znrd1 Polr2f Polr1c Polr1a Polr2k Ercc2 Ttf1 Rrn3 LOC100912534 Hdac2 Cdk7 Mbd3 Twistnb Hdac1l Chd3 Polr1e Chd4 Ccnh Mta3 Gtf2h3 Mta1 Mta2 Gatad2a Gtf2h5 Tbp Gtf2h4 LOC100910121 Gatad2b SCAVENGING OF HEME FROM PLASMA%REACTOME%R-RNO-2168880.1 Scavenging of heme from plasma Hba1 Ambp Lrp1 LOC287167 Apol2 RGD1309808 Apoa1 Cd163 Hbb-b1 Apol11a Apol3 Hpx LOC100910885 Apol9a MAP3K8 (TPL2)-DEPENDENT MAPK1 3 ACTIVATION%REACTOME DATABASE ID RELEASE 66%10145702 MAP3K8 (TPL2)-dependent MAPK1 3 activation Nfkb1 Skp1 Map3k8 Fbxw11 Chuk Ikbkb Tnip2 Btrc Cul1 SYNTHESIS OF 5-EICOSATETRAENOIC ACIDS%REACTOME%R-RNO-2142688.1 Synthesis of 5-eicosatetraenoic acids Alox5ap Pon3 Pon1 Pon2 Ltc4s Alox5 MYOGENESIS%REACTOME%R-RNO-525793.1 Myogenesis Cdh2 Ctnna1 Myf5 LOC100909750 Myf6 Mapk12 Tcf4 Cdon Myog Cdc42 Boc Myod1 Mef2c Spag9 Cdh15 Mapk14 Mef2a Mapk11 Abl1 CHONDROITIN SULFATE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 66%10145919 Chondroitin sulfate biosynthesis Vcan Ncan Bcan Chst7 Chpf2 Chst9 Chsy1 Chst12 Chst11 LOC100910284 Dcn Csgalnact1 Csgalnact2 Chst13 LOC102550316 Chst3 Cspg5 Cspg4 Chpf Chst15 SIGNALING BY LEPTIN%REACTOME DATABASE ID RELEASE 66%10145709 Signaling by Leptin Stat5a ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1%REACTOME DATABASE ID RELEASE 66%10145597 ADP signalling through P2Y purinoceptor 1 P2ry1 Src Gnb3 Gnb5 Gnb2 Gnb1 Gnaq Gna11 Gng13 Gna14 Gng12 Gna15 Gng11 Pla2g4a LOC100912034 Gnb4 Gng4 Mapk14 Gngt2 Gng5 Gngt1 Gng10 Gng8 Gng3 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE%REACTOME%R-RNO-2559586.1 DNA Damage Telomere Stress Induced Senescence Asf1a Ep400 LOC100911837 Rad50 Ubn1 Ccna2 Cabin1 Ccne2 Ccna1 Ccne1 Hira Atm Hist1h2bo Tinf2 Hist1h2bcl1 Hist1h2bk Cdk2 Terf2ip Nbn Mre11a LOC100910200 H2afx Hist1h4b Hist1h2bh Acd LOC100912290 Pot1b Hist1h4m LOC103690002 LOC100910152 Pot1 LOC100912338 H2afb3 Hist2h4 H2afj Hist2h2aa3 Hist1h2bq Hist2h2aa2 LOC100364835 Cdkn1a Terf1 LOC100910954 Cdkn1b Terf2 Hist1h2bg LOC680097 LOC684797 LOC100912418 Hist1h2ba Hist3h2bb FATTY ACYL-COA BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 66%10144901 Fatty acyl-CoA biosynthesis Tecr Tecrl LOC100365676 Hsd17b3 Acly Hsd17b8 LOC100912469 Acsbg1 Ppt1 Ppt2 Elovl1 Cbr4 Elovl5 Elovl2 Slc25a1 Elovl3 Elovl6 Acsbg2 Acsl3 Acsl1 Acsl6 Morc2b Acsl5 Acsl4 Hacd1 Scd4 Scd1 Scd2 Acsf3 Hacd4 Hacd3 Morc2 LOC681458 Hsd17b12 Fasn LOC100911941 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME%R-RNO-69580.1 p53-Dependent G1 S DNA damage checkpoint Psmc6 Psmb10 Mdm2 Psmb8 Psmb9 Psmb4 Psmb11 Psmb5 Psmf1 Psmb6 Psmd4 Psmb2 Psmd5 Psmd8 Psmd9 Psmb3 Psma8 Psmd11 Psmd12 Ccna2 Ccne2 Ccna1 Psmd13 Psmd14 Ccne1 Phf20 Atm Cdk2 Psmc3 Zfp385a Rfwd2 G6pc Psmb7 Psmb1 Psma5 Cdkn1a Cdkn1b LOC100910954 Mdm4 Chek2 Psma2 Psmc5 Psmd2 Psma1 Psma4 Psmc1 Psma3 Psmc4 Psmc2 Psma6 Psme1 Psmd1 Psme2 Psmd7 Psmd3 Psmd6 RSK ACTIVATION%REACTOME DATABASE ID RELEASE 66%10145660 RSK activation Rps6ka2 Rps6ka1 Rps6ka3 Rps6ka6 Pdpk1 Mapk1 PROCESSING OF CAPPED INTRONLESS PRE-MRNA%REACTOME%R-RNO-75067.1 Processing of Capped Intronless Pre-mRNA Ncbp2 Snrpf Ncbp1 Wdr33 Papola Cpsf7 Cpsf2 Cpsf3 Cpsf4 Pcf11 Cstf2t Fip1l1 Sympk Lsm10 Cstf1 Lsm11 Cpsf1 Nudt21 Slbp Zfp473 Snrpd3 Clp1 Cstf2 Snrpb DUAL INCISION IN GG-NER%REACTOME DATABASE ID RELEASE 66%10146140 Dual Incision in GG-NER Rfc1 Rfc2 Gtf2h1 Gtf2h2 Ddb2 Pole2 Pole4 Ddb1 Rbx1 Ercc5 Ercc3 Rpa1 Rpa2 Chd1l Ercc2 Ercc1 Parp2 Rpa3 Parp1 Pole Pold2 Pcna Pold1 Cul4b Pold4 Cul4a Xpa Gtf2h3 Rfc5 Rfc4 Rfc3 Gtf2h5 Gtf2h4 CONDENSATION OF PROPHASE CHROMOSOMES%REACTOME DATABASE ID RELEASE 66%10145955 Condensation of Prophase Chromosomes LOC100909949 LOC100910200 H2afx Mcph1 Hist1h4b RGD1563307 LOC684841 Hist1h2bh Rb1 LOC100912290 Hist1h2ail1 Hist1h4m LOC102549173 LOC103690002 LOC100910152 LOC100912338 Ncaph2 Hist1h3c H2afb3 Hist1h3f Hist2h4 LOC684819 Hist1h3a Smc4 H2afj Hist2h2aa3 Hist1h2bq Smc2 Hist2h2aa2 RGD1310212 LOC100364835 LOC684762 Hist1h2bo Hist1h2bcl1 Hist2h3c2 Hist1h2bk H3f3b Cdk1 Ncapg2 Hist1h2bg LOC680097 Setd8 LOC684797 LOC100912418 Hist1h2ba Hist3h2bb REGULATION OF TP53 ACTIVITY%REACTOME%R-RNO-5633007.1 Regulation of TP53 Activity Rhno1 Bard1 Rfc2 Wrn Topbp1 Rbbp8 Usp7 Rmi1 Mdm2 Rmi2 Banp Rad50 Cdk5 Csnk2a2 LOC364561 Pin1 Brd7 Csnk2a1 LOC685619 Ccna2 Ccna1 Rffl Plk3 Pml Ccng1 Prkab1 Tp73 Phf20 Atm Prkab2 Rictor Atrip Cdk2 Rpa3 Tp53bp2 Atp5c1 Rad1 Brca1 Taf7l Atr Blm Mapkapk5 Rad17 Setd8 Rfc5 Rad9a Tmem55b Rfc4 Pip4k2b Rfc3 Nbn Pip4k2c Rad9b Mre11a Ing2 Hus1 Akt1 Hdac1 Nuak1 Rpa1 Brpf3 Ppp2cb Ppp2ca Rpa2 Hipk2 Brpf1 Ppp2r1a Brd1 Taf7 Taf3 Taf6 Kat6a Taf5 Ing5 Mtor Tp53inp1 Prkag3 Tp63 Ppp2r1b Mlst8 Prkaa1 Prkaa2 Akt3 Slc25a16 Ssrp1 L3mbtl1 Mapk14 Mapk11 Map2k6 Dyrk2 Tp53rk Supt16h Prmt5 Aurka Hdac2 Mbd3 Chd3 Hdac1l Chd4 Aurkb Zfp385a Mta2 Gatad2a Tbp Meaf6 Gatad2b Akt2 LOC100909949 Smyd2 Rbbp7 Cdk5r1 Ehmt2 Ehmt1 Taf11 Ppp2r5c Taf2 Taf15 Taf13 Taf9 Taf12 Taf4b Noc2l Usp2 Csnk2b Tpx2 Daxx Pou4f2 LOC100910954 Cdk1 Hipk1 Mdm4 Chek2 Rnf34 Pdpk1 Taf10 Mapkap1 Sgk1 Ppp1r13b Ppp1r13l Ttc5 Taf9b MICROTUBULE-DEPENDENT TRAFFICKING OF CONNEXONS FROM GOLGI TO THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 66%10145301 Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane Gja1 ER TO GOLGI ANTEROGRADE TRANSPORT%REACTOME%R-RNO-199977.1 ER to Golgi Anterograde Transport Areg Stx5 Sec24a Bet1 Sec24b Arf5 Dync1li2 Copa Cnih1 Sec24d Dync1i2 Arf4 Ctage5 Gbf1 Cnih3 Cnih2 Cog4 Tgfa Cog6 Cog8 Cog3 Cog1 Cog2 Sec23ip Lman1l Cog7 LOC102555167 Dynll2 Copz2 Dync1i1 Copz1 Col7a1 Lman2 F8 Ykt6 Sec16a Scfd1 Sec24c Sec16b Lman1 Tmed7 Trappc2 Tmed3 Trappc5 Tmed2 Napg Napb Copb1 Napa Tmed9 Tfg Nsf Trappc3 LOC100910318 Kdelr1 Tbc1d20 Capza2 Capza3 Arcn1 Kdelr2 Ppp6r3 Trappc1 Ppp6r1 Kdelr3 Trappc10 LOC100910557 Sptan1 Ppp6c Actr10 Trappc2l Cd59 Dync1h1 Dync1li1 Trappc6a Trappc6b Copg1 Ankrd28 Sec13 Dctn5 Dctn6 Sar1b Ins1 Ins2 Rab1b Rab1a Dctn4 Tmem115 Folr1 Arfgap2 Dctn1 Ank1 Ctsc Dctn2 Uso1 Golgb1 Arfgap3 Gorasp1 Ctsz Dctn3 Arfgap1 Spta1 Mcfd2 Preb Capzb Sec22b Cope Sec23a Sptbn1 Sec31a Sec22a Stx17 Csnk1d Actr1a Gosr2 Gosr1 LOC100363782 Tmed10 IRON UPTAKE AND TRANSPORT%REACTOME DATABASE ID RELEASE 66%10145283 Iron uptake and transport Atp6v1d Ftl1 Slc11a2 Cul1 Heph Tfrc Tf Slc46a1 Atp6v1g1 Hmox1 Atp6v1g2 Ireb2 Aco1 Atp6v0a4 Atp6v1b2 Ftmt Atp6v0a2 Atp6v1h Atp6v1f Tfr2 Hfe Abcg2 Abcg3l3 Abcg3l1 Steap2 Cybrd1 LOC100911874 Cand1 Fbxl5 Atp6v0c Nedd8 RGD1561661 Tcirg1 Hmox2 Atp6v0d1 Atp6v1c2 Atp6v0d2 Skp1 Atp6v1a LOC100360087 Atp6v0e2 Atp6ap1 Atp6v0e1 Atp6v1g3 Atp6v1e1 Atp6v1e2 Atp6v1c1 Atp6v0a1 Slc40a1 Mcoln1 Cp CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION%REACTOME DATABASE ID RELEASE 66%10145415 Class I MHC mediated antigen processing & presentation Rnf41 Sec24a Sec24b Vhl Sec24d Asb18 Asb11 Asb12 Asb13 Rbx1 Asb14 Asb10 Socs3 Keap1 Uba7 Traf7 Asb15 Glmn Asb17 Uba5 Asb16 Hecw2 Mrc2 Ube2l6 Rbbp6 Mrc1 Ube3d Ube3b Trim11 Lrsam1 Ube3a Npepps Ube2o Rbck1 Ube2u Hectd3 Hectd1 RT1-A2 Rnf6 Ncf1 Erap1 RT1-A1 Ncf4 Rnf4 Cd207 B2m Tap1 Tap2 Traip Rnf25 Anapc13 Lnx1 Rnf19a Rnf19b Herc3 Ube2v2 Arih2 Herc6 Tapbp Stx4 Ube2n Tpp2 Ubox5 Ube2j2 Arel1 Ube2j1 Rnf182 Sec24c Rnf14 Ltn1 Cblb Sh3rf1 Pja1 Pja2 LOC100911393 Dtx3l Znrf2 Znrf1 Trim9 Blmh LOC100911400 Rnf115 Trim63 Ube2d1 Dzip3 Trip12 Ubr2 Trim71 Vprbp Trim69 Trim39 Ube4a Herc2 LOC100910646 Ufl1 Trim50 Ubac1 Ube2q1 Thop1 Rlim Ube2d3 Mex3c Rchy1 Mgrn1 Trim41 Hace1 Trim36 Trim37 Stub1 Anapc7 Fcgr1a Calr Cdc26 Cdc27 Fbxl22 Cdc23 Rnf144b Lrrc41 Ube2c Skp2 Fbxw10 Fbxw12 Cdc16 Anapc4 Anapc2 Anapc1 Trim21 Trim32 Cul1 Wwp1 Atg7 Canx Anapc11 Anapc10 Fzr1 Siah1 Siah2 Vamp8 Sec13 Sar1b LOC685953 Cd36 G6pc Klhl5 Cdc20 Psmb7 Psmb1 Klhl2 Fbxo2 Fbxo9 Fbxo7 Fbxo6 Psma5 Fbxo4 Ube2k Ube2h Ube2f Sec31a Psma2 Ube2a Psmd2 Klhl9 Psmc2 Psmd1 Lrr1 Psmd7 Psmd3 Psmd6 Psmc6 Psmb10 Psmb8 Psmb9 Rnf123 Psmb4 Psmb11 Fbxl19 Psmb5 Psmf1 Psmb6 Fbxl12 Fbxl13 Psmd4 Psmb2 Fbxl16 Fbxl15 Psmd5 Psmd8 Psmd9 Psmb3 Psma8 Ccnf Psmd11 Psmd12 Ube2e3 Psmd13 Psmd14 RT1-M3-1 Tceb2 Ube2z Tceb1 Cul2 Ube2s Psmc3 LOC100364500 RT1-S3 Fbxl4 Fbxl5 Fbxl8 RT1-CE2 Kctd7 RT1-CE3 RT1-CE4 RT1-CE7 Rnf7 RT1-CE5 RT1-CE10 Skp1 Kbtbd8 Kbtbd7 Kbtbd6 Kctd6 Ube2q2 Ube2r2 Fbxw11 Hspa5 Btrc LOC683761 Gan LOC100364956 LOC100362142 LOC100912618 Ube2v1 Fbxl18 Fbxl7 Asb5 Asb6 Asb7 Klhl41 Asb1 Asb3 Cdc34 Asb8 Klhl42 RT1-A Smurf1 Ube2m Fbxo41 Fbxo44 RGD1565355 Fbxo40 Cybb Cyba Wsb1 RT1-M2 Spsb2 RT1-M5 RT1-M4 Spsb1 Ubr4 Spsb4 Btbd1 Btbd6 Fbxo22 Ube2g2 Ube2g1 Klhl13 Fbxo30 Fbxo31 Klhl11 Fbxo32 Fbxo21 Klhl20 Zbtb16 Klhl25 Klhl21 Uba1 Klhl22 Fbxo10 Socs1 Fbxo15 Fbxo11 Sec22b Sec23a Fbxw2 Mylip Uba6 RT1-M6-1 Rnf34 Psmc5 Fbxw9 Psma1 Uba3 Psma4 RT1-M6-2 Psmc1 Fbxw5 Psma3 Fbxw4 Psmc4 Fbxw8 Psma6 Fbxw7 Psme1 Psme2 Vamp3 LOC100909844 POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%R-RNO-622327.1 Postsynaptic nicotinic acetylcholine receptors Chrnb4 Chrne Chrnd Chrna4 Chrna5 Chrna9 Chrna6 Chrnb2 Chrna7 Chrnb3 Chrna2 Chrna3 Chrna1 INTERLEUKIN-15 SIGNALING%REACTOME%R-RNO-8983432.1 Interleukin-15 signaling Stat5a Jak3 Il2rg Jak1 Stat3 Sos1 Sos2 Shc1 Il15 Grb2 Il2rb CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE%REACTOME%R-RNO-176407.1 Conversion from APC C:Cdc20 to APC C:Cdh1 in late anaphase Anapc7 Cdc26 Cdc14a Cdc27 Cdc23 Ube2c Ube2d1 Anapc16 Cdc16 Cdc20 Anapc4 Anapc2 Anapc1 Anapc11 Anapc15 Anapc10 Fzr1 ACTIVATED NTRK2 SIGNALS THROUGH FYN%REACTOME DATABASE ID RELEASE 66%10146323 Activated NTRK2 signals through FYN Gab1 Hgf Crk Crkl Dock7 Rac1 Grb2 LOC100911248 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF SATURATED FATTY ACIDS%REACTOME%R-RNO-77286.1 mitochondrial fatty acid beta-oxidation of saturated fatty acids LOC100911186 Echs1 Hadh Acadl Acads Hadha Hadhb Acadm Acadvl MET ACTIVATES RAP1 AND RAC1%REACTOME DATABASE ID RELEASE 66%10146252 MET activates RAP1 and RAC1 Gab1 Hgf Crk Rap1a Crkl Dock7 Rapgef1 Rac1 Grb2 LOC100911248 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION%REACTOME%R-RNO-156827.1 L13a-mediated translational silencing of Ceruloplasmin expression LOC100912571 Eif3l Eif2s3 Eif3m Eif3j Eif3k Rps20 Rps27l Eif3e Eif3f Eif3b Eif3a Eif3d Eif3c LOC100360573 Eif2s1 Eif2s2 Eif4g1 Rps4x LOC100359951 LOC100359593 LOC100359503 LOC100362640 Rpl13a Rps3 Rps15a Rps2 Rps13 Rps12 Pabpc2 Pabpc6 LOC100911372 LOC100361854 LOC684988 LOC103689992 Rps5 Rps7 Rps6 Eif3g Eif3h Eif4a2 LOC100362830 Eif1ax Eif4a1 LOC100363012 LOC680559 LOC100911110 LOC100362149 Rps16 LOC100911431 Pabpc1 Rps18 LOC100360679 Rps15 Eif4h Eif4b Rps3a HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME%R-RNO-5693579.1 Homologous DNA Pairing and Strand Exchange Rhno1 Rfc2 Bard1 Wrn Topbp1 Rbbp8 Rmi1 Rmi2 Rad51c LOC100911267 Hus1 Rad51d Rad51 Brca2 Rad50 Rpa1 Rpa2 Atm Atrip Rpa3 Xrcc3 Brca1 Rad1 Atr Blm Rad17 Slc25a16 Palb2 Rfc5 Xrcc2 Rfc4 Rad9a Nbn Rfc3 Rad9b Mre11a P75NTR SIGNALS VIA NF-KB%REACTOME%R-RNO-193639.1 p75NTR signals via NF-kB Ripk2 Prkci Nfkb1 Sqstm1 Ngf Nfkbia Ngfr Ikbkb Rela Myd88 Traf6 CELL-CELL COMMUNICATION%REACTOME DATABASE ID RELEASE 66%10145431 Cell-Cell communication Pvrl3 Crb3 PVR Pvrl4 Rsu1 Pvrl1 Cdh10 Kirrel Cdh11 LOC100911730 Kirrel3 Cdh17 Cdh13 Kirrel2 Cdh7 Cdh9 Fermt2 Flnc Inadl Cdh24 Pard6b Fyb Cd151 Nck1 Lamc2 Itgb4 Cadm3 Itga6 Cadm2 Mpp5 Ang2 Skap2 Flna Cd47 Fyn Pvrl2 Plec Wasl Cdh15 LOC100909879 Actn1 Lamb3 Nck2 Parvb Lims1 Arhgef6 Ilk Pard6a Ptk2b Dst F11r Jup Prkci LOC100360575 Sirpa Tyrobp Fblim1 Vasp Pard3 Cdh1 LOC100909977 Cdh2 Ctnna1 Sdk2 Ctnnd1 Cdh3 Pard6g Cdh5 Iqgap1 Cdh6 Col17a1 Grb2 RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASES%REACTOME DATABASE ID RELEASE 66%10145543 Receptor-type tyrosine-protein phosphatases Ptprd Il1rapl1 Slitrk6 Slitrk5 Slitrk3 Slitrk2 Slitrk1 Il1rap Ppfibp1 Ppfibp2 Ptprf Lrrc4b Ppfia1 Ppfia2 Ppfia3 Ppfia4 Ntrk3 SULFIDE OXIDATION TO SULFATE%REACTOME DATABASE ID RELEASE 66%10145889 Sulfide oxidation to sulfate Suox Sqrdl Ethe1 Tstd1 Slc25a10 SIGNALING BY EGFR%REACTOME DATABASE ID RELEASE 66%10144957 Signaling by EGFR Src Kras Arhgef7 Eps15l1 Pik3r1 Pxn Egfr Gab1 Csk Ptpn3 Spry2 Cbl Cdc42 Ptpn11 Stam2 Sh3gl2 Sh3gl1 Sh3kbp1 Plcg1 Ptprk Hras Spry1 Sh3gl3 Nras Sos1 Ptpn12 Lrig1 Shc1 Stam Grb2 INVADOPODIA FORMATION%REACTOME DATABASE ID RELEASE 66%10146271 Invadopodia formation Adam12 Adam19 Sh3pxd2a Adam15 P53-DEPENDENT G1 DNA DAMAGE RESPONSE%REACTOME%R-RNO-69563.1 p53-Dependent G1 DNA Damage Response Psmc6 Psmb10 Mdm2 Psmb8 Psmb9 Psmb4 Psmb11 Psmb5 Psmf1 Psmb6 Psmd4 Psmb2 Psmd5 Psmd8 Psmd9 Psmb3 Psma8 Psmd11 Psmd12 Ccna2 Ccne2 Ccna1 Psmd13 Psmd14 Ccne1 Phf20 Atm Cdk2 Psmc3 Zfp385a Rfwd2 G6pc Psmb7 Psmb1 Psma5 Cdkn1a Cdkn1b LOC100910954 Mdm4 Chek2 Psma2 Psmc5 Psmd2 Psma1 Psma4 Psmc1 Psma3 Psmc4 Psmc2 Psma6 Psme1 Psmd1 Psme2 Psmd7 Psmd3 Psmd6 METAL SEQUESTRATION BY ANTIMICROBIAL PROTEINS%REACTOME DATABASE ID RELEASE 66%10145804 Metal sequestration by antimicrobial proteins S100a8 Ltf SUMOYLATION OF IMMUNE RESPONSE PROTEINS%REACTOME%R-RNO-4755510.1 SUMOylation of immune response proteins Nfkb2 Nfkbia Sumo1 Pias3 Pias4 Ube2i Rela Sumo3 Ikbke Topors LYSINE CATABOLISM%REACTOME%R-RNO-71064.1 Lysine catabolism Pipox Aldh7a1 LOC100910122 Gcdh Ogdh Aadat Dlst Phykpl Hykk Dld ARL13B-MEDIATED CILIARY TRAFFICKING OF INPP5E%REACTOME DATABASE ID RELEASE 66%10146085 ARL13B-mediated ciliary trafficking of INPP5E Inpp5e Arl13b Pde6d TRANSPORT OF FATTY ACIDS%REACTOME%R-RNO-804914.1 Transport of fatty acids Apod Slc27a6 Vegp2 Lcn9 Lcn12 Lcn1 Slc27a4 Slc27a1 COPI-DEPENDENT GOLGI-TO-ER RETROGRADE TRAFFIC%REACTOME%R-RNO-6811434.1 COPI-dependent Golgi-to-ER retrograde traffic Kif21a Kif21b Kifc1 Kif3c Racgap1 Klc1 Bnip1 Arf5 Kif22 Kif3b Copa Kif23 Kif18b Kifap3 Kif11 Kif12 Kif4a Kif6 Kif1a Kif1c Arf4 Use1 Gbf1 Klc4 Kif27 Kif9 Kif13b Cenpe Klc2 Stx18 Klc3 Kif3a LOC102555167 Copg1 Copz2 Copz1 Rab1b Rab1a Nbas Tmed7 Arfgap2 Tmed3 Tmed2 Napg Arfgap3 Napb Copb1 Napa Kif2a Arfgap1 Kif2c Kif2b Tmed9 Kif18a Nsf Kif5b Kif5a Kdelr1 Sec22b Cope Arcn1 Kif20b Kif16b Kif26a Kif20a Kif26b Kif19 Kdelr2 Zw10 LOC100363782 Tmed10 Kdelr3 METABOLISM OF PROTEINS%REACTOME DATABASE ID RELEASE 66%10144825 Metabolism of proteins Usp7 Ddb2 Pias3 Pias1 Ffar1 Yy1 Ddb1 Rbx1 Actr8 Stag1 Rad21 Smc1a Stag2 Actl6a Smc3 Mcrs1 Cops8 Cops2 Actb Sumo1 Sumo3 Ino80 Pcna Cul4b Cul4a Ube2v2 Xpc Ube2n Ube2i Ruvbl1 Bche Hist1h2aa Cct6b Gnai3 Ache Ercc8 Rpa1 Gnao1 Cct6a Tcp1 Cct7 Cops4 Rgs7 Cct4 Cops6 Gnat2 Pdcl Gnaz Cct3 Cops3 Ripk2 Traf6 Cul1 Commd9 App Tab1 Rela Map3k7 Cd59 Ctsa Cct2 Stam2 Plaur Nfkbia Cct8 LOC100910771 Cst3 Muc20 Qsox1 Stam Rab4a Fcgr3a Ctsc C4a C4b Ctsz Mlec LOC100909666 LOC102549354 Psmb7 Psmb1 Ino80e Ino80d Nfrkb Psma5 Parp1 Rad23a Rad23b Cops7b Cops7a Psma2 Psmd2 Commd3 Klk13 Bst1 Psmc2 Psmd1 Psmd7 Ino80b Psmd3 Ino80c Psmd6 Mrps11 Mrps12 Mrps16 Mrps14 Mrps18b Mrps18c Mrps10 Mrps18a Ccdc22 Mrps33 Fbxl19 Mrps34 Gh1 Mrps21 Mrps35 Mrps17 Fbxl12 Mrps15 Fbxl13 Fbxl16 Mrps31 Fbxl15 Mrps30 Mrps24 Mrps23 Mrps22 mrpl9 Mrps28 Mrps27 Mrps26 Mrps25 LOC100911764 Mrpl4 Mrpl3 Mrpl2 Oxa1l Igfbp6 Mtrf1l Igfbp2 LOC367117 Tgfa Napsa Prnd Pappa2 Eif5a Pex2 Eif2ak3 Derl1 Klk1c12 Csf1 Mrrf Ttll10 Klk1c10 Clspn Rad18 Mrpl1 Mrpl13 Wfs1 Mrpl10 Pex5 Mrpl18 Ube2z Mrpl19 Dcun1d5 Mrps9 Dcun1d4 Mrps2 Dcun1d3 Mrps5 Ube2t Mrps7 Ube2s Ttll9 Mrpl36 LOC100909521 Mrpl37 Ttll4 Mrpl20 Ttll5 Ccdc59 Ttll3 Mrpl14 Ttll7 Mrpl16 Mrpl12 Ttll2 Mrpl15 Nae1 Fbxl4 Zdhhc2 Fbxl5 Mrpl41 F8 Mrpl35 Scfd1 Mrpl40 F7 Mrpl33 Tshb F9 Mrpl34 Ttll12 Mrpl38 Rbbp5 Fbxl8 Mrpl32 Mrpl27 LOC304903 Mrpl23 Mrpl28 Mrpl30 Mrpl21 Mrpl54 Lmcd1 Mrpl46 Mrpl55 Mrpl44 Mrpl43 Mrpl47 Mrpl49 Mrpl53 Mrpl48 Mrpl52 Gnat3 Mrpl51 Dpp4 Lep Mrpl50 Grp Gpr119 Ffar4 Skp1 Tnks Phc1 Phc2 Nfkb2 Fbxw11 Tfap2c Btrc Nod1 Nod2 Adora2a Adora2b Tnip2 Rxra Apol2 Prmt3 Hsp90b1 RGD1309808 Apol11a Apol3 LOC100910885 Apol9a Hist1h2bo Scmh1 Hist1h2bcl1 Cbx4 Hist1h2bk Cbx2 Cbx8 Bmi1 Hdac2 Rnf2 Usp13 Ring1 Phc3 Ogt Tnks2 Mta1 LOC100910717 LOC100910200 Hist1h4b Wdr5 Hist1h2bh Dnmt1 LOC100912290 Rbbp7 Hist1h4m LOC100912338 Dnmt3b Hist2h4 Hist2h2aa3 Hist1h2bq Hist2h2aa2 LOC100364835 Adgrf5 Sar1a Sftpa1 Pappa mrpl11 mrpl24 Chchd1 Igfals Dap3 Eral1 Gadd45gip1 Klk10 Klk1c6 Ict1 Ptcd3 Msrb2 Msrb3 Gfm2 Hist1h2bg Gfm1 Sftpb LOC680097 Msra LOC684797 Klk1c8 LOC100912418 Klk1c9 Hist1h2ba Klk1c2 Klk1c3 Mgat2 Mgat5 Mettl20 Mettl22 Sec24a Sec24b Copa Sec24d Mysm1 Asb18 Mgat3 Asb11 Asb12 Mgat1 Rgs9 Asb13 Asb14 Asb10 Keap1 Wdtc1 Fkbp8 Man1c1 Asb15 Asb17 Asb16 Adamts1 Man1a1 Adamts6 Adamts7 Uimc1 Adamts9 Sspo Cyr61 Cog4 Cog6 Cog8 Cog3 Ntng1 Ntng2 Cog1 Cog2 Chgb Igfbp1 Sec23ip Lman1l Igfbp5 Cog7 LOC102555167 Igfbp4 Alpl Kng1l1 Cand1 Afp Rab39a Gnat1 Mul1 Mfge8 Rab11b Ptp4a2 Cpm Thsd1 Ykt6 Sec24c Paf1 Igfbp7 Rfwd2 Notum Tmed7 Tmed3 LOC100911393 Tmed2 Eef2kmt Tex101 Aplp2 Rab6b Rab9a Napg Napb Napa Rtf1 Senp5 Mepe LOC100910849 Pigm Pigk Tmed9 Pigl Pigg LOC100911374 Pigh Nsf Dcaf11 Pigc Dcaf13 Pigb Piga Ankrd9 Dcaf10 Rab8b Pex14 Pex10 Pex13 Pex12 Fbxl22 Lrrc41 Ube2c Usp47 Usp48 Skp2 Fbxw10 Usp42 Chm Fbxw12 Ngly1 Fn3k Arcn1 Rab7b Becn1 Traf2 Pigw Pigv Pigy Pigx Rab33a Rab33b Pign Pigq Pigp Mxra8 Pigs Nucb1 Pigu Pigt Usp20 Usp26 Ggcx Usp21 Obsl1 Usp22 Rab2a Rab2b Trappc10 LOC100910410 Rab35 Rab34 Ly6g6c Rab36 Rabggta Usp19 Spon2 Spon1 Fn3krp Usp37 Il33 Ppp6c Manea Rab3c Rab3b Usp30 Vgf Neurl2 Trappc2l Rab43 Usp24 Usp25 Rab25 Stc2 Rab20 Rab21 Rab19 Prss41 Vdac1 Engase Rab23 Prss23 Prss21 Trappc6a Trappc6b Rab15 Rab12 Rab13 Ankrd28 Rabggtb Rab32 Rab30 Ly6g6d Usp14 Rab38 Usp18 Usp15 Rab1b Rab1a Usp11 Usp10 Tmem115 Ufd1l Sbspon Spaca4 Arfgap2 Dph1 Dcaf8 Atxn3 Dph3 Gpihbp1 Golgb1 Dph2 Klhl5 Arfgap3 Atxn7 Dcaf4 Sparcl1 Arfgap1 Dph5 Dph6 Ubxn1 Otoa LOC690251 LOC100910472 Penk Mcfd2 Preb Chst10 Kng1 Capzb Vdac2 Klhl2 Foxo4 Fbxo2 Eva1a Kng2 Fbxo9 Fbxo7 Cdh2 Rwdd3 Fbxo6 Fbxo4 Proz Cul9 Dcun1d2 Ube2k Plet1 Ube2h Ube2f Sec31a Ube2a Stx17 Pomt2 Pomgnt2 Dcaf7 Pomt1 Pros1 Klhl9 Dcaf5 Dcaf6 Dda1 Bglap Lrr1 Dhps Gosr2 Gosr1 Tmed10 Pomgnt1 Hrc LOC100912571 Wdr20 Eif3l Areg Eif2s3 Stx5 Eif3m Bet1 Eif3j Arf5 Eif4ebp1 Etfb Cnih1 Eif3k Shisa5 Fuca2 Rps20 Rnf123 Rps27l Pofut2 Eif3e Mfi2 Eif3f Wdr48 Eif2b1 Izumo1r Eif3b Bre Eif3a Cish Eif3d Arf4 Eif3c Bpifb2 Ctage5 Asgr1 Large Brcc3 Gyltl1b Rab27a Ccnf Psmd11 Gbf1 Psmd12 Ube2e3 Ccna2 LOC100360573 Ctr9 Ccna1 Eif2s1 Cnih3 Psmd13 Eif2s2 Cnih2 Psmd14 Eif4g1 Dtl Asgr2 Amtn Rps4x Rab7l1 LOC100359951 Wdr61 LOC100359593 Commd7 Eif5 Commd2 Cfp LOC100359503 Commd1 LOC100362640 Rpl13a Man2a1 Fut8 Rps3 Rps15a Serpind1 Man2a2 Rps2 Sprn Rps13 Sema5b Tceb2 Rps12 Mgat4b Pabpc2 Tceb1 Commd4 Pabpc6 Cul2 Commd5 Hif1a LOC100911372 Mgat4a LOC100361854 Commd6 LOC684988 Rnf152 LOC103689992 Psmc3 Enam Rps5 Fem1b Rps7 Fem1a Eif2b5 Serpinc1 Rps6 Epas1 Ptrh2 Eif2b3 Tada3 Eif2b4 Hif3a Copz2 Eif3g Copz1 Eif3h Bcl10 Eif4a2 Reck LOC100362830 Lman2 Eif1ax Sec16a Eif4a1 Sec16b LOC100363012 Lman1 LOC680559 LOC102554393 LOC100911110 Rnf181 LOC100362149 Trappc2 Kctd7 Trappc5 Calu Bmp15 Rnf7 Kin Cd109 Rab27b Babam1 Fem1c Rab3a Josd2 Copb1 Josd1 Suds3 Opcml Eif5a2 Chst8 Rab7a Thy1 Tfg Tada2b Ly6e Ly6d Psca Ly6h Kbtbd8 Otulin Rab22a Rab4b Kbtbd7 Kbtbd6 Mme Gpld1 Neu1 Trappc3 Kctd6 Mettl21a Arsi Pcsk9 LOC100910318 Arse Ube2q2 Hltf Arsg Ube2r2 Rab5b Kdelr1 Amelx Rab5c Rce1 Arsk Tbc1d20 Sts Capza2 Capza3 LOC100910143 Rab6a Commd10 Sumf2 Gan Sumf1 B3galnt2 Atp6ap2 Tecta Thsd7a Vnn3 Fam20c Usp3 Usp4 Usp5 Stambpl1 Kdelr2 Tmem132a LOC100911959 Thsd7b Lgals1 Rab9b Ppp6r3 Trappc1 Ppp6r1 Kdelr3 Tectb Art3 Fam20a Art4 Adamts13 Apc Otub1 Adamts15 Otud3 Ide Otud7b Hist2h2ab Adamts19 LOC100910557 Adamts16 Adamts17 Pomk Ambn Sptan1 Gas6 Vcp Adamts12 Asb5 Rab18 Asb6 Asb7 Msln Klhl41 Rab10 Asb1 Rab14 Asb3 Vnn1 Cdc34 Asb8 Rab24 Zranb1 Rtn4rl2 Actr10 Ripk1 Ifih1 Vcpip1 Klhl42 Tnip1 Gpaa1 Arsa RGD1565607 Otub2 LOC100911993 Rtn4rl1 Tnfaip3 Dync1h1 Lypd5 Tdg Nr5a2 Lypd8 Lypd1 Lypd6b Lypd2 Lypd3 Lypd4 Apeh LOC102553119 Dync1li1 LOC689730 Fbxo41 Thbs2 Bmyc Fbxo44 Polb Fbxo40 Wsb2 Copg1 Wsb1 Spsb3 Dctn5 Dctn6 Esr1 Spsb2 Adamtsl2 Spsb1 Adamtsl3 Gata3 Shprh Rnf20 Ddx5 Adamtsl4 Folr2 Nrip1 Dctn4 Rab3d Spsb4 Pgr Folr1 Ncoa1 Scg2 Btbd1 Btbd6 Fbxo22 Ube2g2 Ube2g1 Dohh Uso1 Scg3 Il6 Klhl13 Fbxo30 Gorasp1 Fbxo31 Klhl11 Fbxo32 Fbxo21 LOC100910107 St8sia1 Ddx58 Klhl20 Alg1 Rps16 Cntn4 Gfpt2 Cntn3 Nus1 Cntn5 Alg2 Pgap1 Dolpp1 Sae1 Gfpt1 St8sia3 Rnf40 LOC100911431 Fam175b Alg6 Pabpc1 Rcn1 Alg3 Zbtb16 Alg9 Rps18 Klhl25 LOC100360679 Alg8 Klhl21 Rps15 Uba1 Eif4h Klhl22 Eif4b Uba2 Rps3a Fbxo10 Renbp St3gal5 Rab40c Mpi Usp2 Rab40b Csnk2b Icmt Pgm3 Fam175a Adra2a Pmm2 Fbxo15 Gnai2 Alg14 Tulp4 Pmm1 Dnajc3 Fbxo11 Adra2c Alg12 Slc35a1 Sec22b Daxx LOC100910954 St8sia5 Cope St6galnac1 Sec23a Cdk1 Mdm4 St6galnac2 C3 Fbxw2 Uba6 Nudt14 LOC501189 Taf10 St8sia4 Gp2 LOC100910177 Sec22a Dolk Senp2 St6gal1 Uba3 Fbxw9 St6gal2 Nub1 Amdhd2 Senp1 St6galnac4 Rhoa Fbxw5 St6galnac3 Eef2 Fbxw4 Nagk Fbxw8 Gne Fbxw7 Mpdu1 Man1a2 Dpagt1 LOC103690024 St6galnac6 Xpnpep2 Gnai1 Gnpnat1 LOC100912059 Dpm3 Ckap4 Serpina10 Dpm2 LOC100363782 Dpm1 Usp17l5 Uap1 Taf9b Trim27 Mdm2 Vhl Pcsk1 Mboat4 Ghrl Socs5 Socs3 Leo1 Vwa1 Stambp Commd8 Socs6 Pias4 Pml Pias2 Brca1 Blm Mdc1 Zfp131 Pcgf2 Hdac4 Uhrf2 Foxl2 Satb2 Satb1 Topors Usp8 Thra Thrb Fuom Nsmce1 Smad3 Slc35c1 Ing2 Nsmce2 Smad2 Mbd1 Nr1h3 Nedd8 Nr1h2 Top1 Safb Usp9x Park7 Ube2d1 Smc6 Tp53bp1 Fuk Smc5 Nr5a1 Tsta3 Rora Gmds LOC100911225 Nr1i2 Rad52 Fpgt Mitf Herc2 Hdac1 Xrcc4 LOC100911274 Timp1 Ube2d3 Cma1 Edem3 Calr Man1b1 Rnf139 Ganab Edem2 Uggt1 Trim13 Dmp1 Rnf5 Prkcsh B3gnt6 Abca3 Galntl5 Galnt6 Galnt5 B3gnt8 Muc1 Plg B3gnt5 Chst4 Galnt1 Ceacam10 Galnt7 Galnt3 Galnt2 Mmp1 Mmp2 Canx Lamc1 Rnf103 March6 Fbn1 Ceacam1 Ikbke Fgg Siah2 Traf3 Thbs1 Sar1b Apob Fga Apoe Apoa2 Lamb1 Dag1 Lamb2 Gng10 Spp1 Ank1 Nop58 Adamts4 Adamts3 Adamts5 Sema5a Ctsd Creb3l3 Crebrf Ctsg Spta1 Creb3 Fn1 P4hb Adamts14 Nans Sptbn1 Npl Dhdds Cmas Ltbp1 Nanp Sec11c MGC109340 Pla2g7 Spcs2 Sec11a Bard1 Pten Csf2ra Csf2rb Lhb Rab8a Ccp110 Furin Alpp Alpi Mvd Bmp4 Col7a1 F2 Cga Gzmf Ace3 Cpa3 Npepo Neu4 Ero1l Neu2 Gzmn Ero1lb Inha Exoc3 Inhbc Neu3 LOC100910060 Exoc2 Exoc1 Exoc6 Exoc5 Exoc8 Exoc7 Cpb2 Cpb1 Ren Fshb Agt Srd5a3 Ace LOC691670 Sin3a Txn1 Rraga Galnt9 LOC102550196 Gcnt1 A4gnt Muc13 C1galt1 Muc15 C1galt1c1 Galnt16 Galnt18 Galnt14 Galnt15 Galnt12 Galnt13 B3gntl1 Galnt10 Tgfbr1 Ube2m Hdac1l Dctn1 Cdc73 Dctn2 Dctn3 Os9 Usp33 Slc17a5 Rab11a Arrb1 Csnk1d Arrb2 Atf6 Actr1a Sel1l Nr1h4 Mbtps1 Dync1li2 Mbtps2 Kat2a Dync1i2 Csnk2a2 Csnk2a1 Dynll2 Tomm70a Dync1i1 Tomm20 Birc5 Pomc Nup88 Apoa1 Hipk2 B3gnt4 B3gnt7 Alppl2 B3gnt1 B3gnt2 B3gnt3 Nup85 Nlrp3 Rae1 Pnpla2 Glb1 St3gal2 St3gal3 St3gal1 St3gal4 St3gal6 Nup93 Nup98 Nup107 LOC100363239 Sec61g Ern1 LOC100361694 Nup210 LOC100911750 Ppara Nupl2 Nupl1 Ttf1 Cdca8 Gip Rangap1 B4galt1 Aurkb B4galt3 Sec13 Sec63 B4galt2 Serp1 B4galt6 Sec61a1 Sec62 B4galt4 Sec61a2 B4galt5 Sec61b Asna1 Nup205 Slc30a5 Slc30a6 Slc30a8 Incenp G6pc Ktn1 Nup155 Cdc20 Men1 Slc34a1 LOC100911615 Nup153 Vcan Tpr Arsb Mkl1 Nup54 Pom121 Nup62 Cp Psmc6 Psmb10 Nup43 Nup133 Psmb8 Psmb9 Psmb4 Psmb11 Aaas Psmb5 Psmf1 Psmb6 Psmd4 Psmb2 Psmd5 Psmd8 Npap60 Psmd9 Psmb3 Nup35 Psma8 Nup37 Sdc2 Gspt1 Rhot1 Gspt2 Uchl3 Bap1 Senp8 RGD1561252 Asxl2 Foxk2 Uchl5 Ranbp2 Adrm1 Uchl1 Mat2b N6amt1 Trmt112 Etf1 Gnb3 Gnb5 Gnb2 Gnb1 Gng13 Gng12 Gng11 LOC100912034 Gnb4 Gcg Gng4 Gngt2 Gng5 Gngt1 Gng8 Gng3 Fbxl18 Fbxl7 Tgoln2 Fgf23 Tf Fstl1 Fstl3 Igf2 Igf1 Chrdl1 Ins1 Ins2 Inhba Birc3 Birc2 Cyld P2ry2 Psmc5 Psma1 Psma4 Psmc1 Cdc25a Psma3 Psmc4 Ppa2 Psma6 Psme1 Psme2 LOC100909844 Adrb2 IRF3-MEDIATED INDUCTION OF TYPE I IFN%REACTOME DATABASE ID RELEASE 66%10145930 IRF3-mediated induction of type I IFN Nlrp4 Dtx4 Tbk1 Nlrp4a Irf3 Tmem173 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION%REACTOME%R-RNO-2565942.1 Regulation of PLK1 Activity at G2 M Transition Bora Cul1 Dync1i2 Cep57 Rab8a LOC691918 Haus3 Ninl Aurka Akap9 Ccp110 Dync1h1 Pafah1b1 Ppp1r12a LOC103692716 Ppp1cb Ajuba Dctn1 Cntrl Dctn2 Cep76 Pcm1 Cep78 LOC100911033 Cep164 Dctn3 Ofd1 Cep41 Sdccag8 Tubb5 Prkar2b Cenpj Skp1 Ywhag Ppp2r1a Plk4 Ywhae LOC100912076 Tubg2 Haus2 Haus1 Haus5 Alms1 Haus4 Clasp1 Fbxw11 Odf2 Tubb4a Cdk1 Nek2l1 Btrc Ssna1 Mapre1 Tubg1 Cep63 Prkaca Csnk1d Cep131 Tuba4a Cep250 Cep135 Csnk1e Ckap5 Cdk5rap2 Pcnt Nek2 Cep72 Sfi1 Cep70 Actr1a Optn Nedd1 INTERLEUKIN-33 SIGNALING%REACTOME%R-RNO-9014843.1 Interleukin-33 signaling Il33 Il1rl1 Il1rap MHC CLASS II ANTIGEN PRESENTATION%REACTOME DATABASE ID RELEASE 66%10145936 MHC class II antigen presentation Kif3c Racgap1 Sec24a Klc1 Kif22 Sec24b Dync1li2 Kif3b Sec24d Kif23 Kifap3 Kif11 Kif4a Dync1i2 RGD1308751 Dnm2 Klc4 Cenpe Klc2 Klc3 Ap2a2 Cts8l1 Kif3a Ap1b1 Dynll2 Dync1i1 Sec24c Cltc Rab7a Clta RT1-Ba RT1-Bb RT1-Da RT1-Db2 Ap2s1 RT1-Db1 LOC688090 Ap2a1 Ap2m1 MGC114246 Capza2 Capza3 Testin Kif26a Kif20a Ap1s3 Ap1s1 Ap1s2 Lgmn Canx Ap1m2 Actr10 Dync1h1 Ctsa Dync1li1 Actr1b LOC100364523 Sec13 Dctn5 Dctn6 Sar1b Sh3gl2 Dctn4 Dctn1 Ctsc Dctn2 Dctn3 Kif2a Kif2c Kif2b Ctsd RT1-DMa Ctsb Ap1m1 RT1-DMb Cd74 Kif18a Ctsl Lag3 Ctsm Rilp Ctsj Ifi30 RGD1564657 Capzb Ctsk Kif5b LOC100909593 Ctsq LOC100909630 Ctsr RT1-DOb Kif5a RT1-DOa Ctse Ctsf Dnm1 Dnm3 Sec23a Sec31a Cts8 Cts7 RGD1564827 Actr1a DNA REPLICATION%REACTOME%R-RNO-69306.1 DNA Replication Rfc1 Psmc6 Rfc2 Psmb10 Psmb8 Pole2 Psmb9 Pole4 Psmb4 Psmb11 Psmb5 Psmf1 Psmb6 Psmd4 Psmb2 Rbx1 Psmd5 Psmd8 Psmd9 Psmb3 Psma8 Psmd11 Psmd12 Prim2 Ccna2 Ccne2 Pola2 Ccna1 Psmd13 Prim1 Ccne1 Psmd14 Mcm2 Mcm4 Mcm3 Cdk2 Mcm5 Rpa3 Mcm6 Pole Mcm10 Pcna Psmc3 Mcm8 Mcm7 Orc4 Orc5 Orc6 Orc1 Orc2 Orc3 Rfc5 Cdc7 Rfc4 Rfc3 Cdc6 Cdc45 Ube2d1 Rpa1 Rpa2 Skp1 Lig1 Anapc7 Cdc26 Cdc27 Cdc23 Ube2c Skp2 Anapc16 Cdc16 Anapc4 Anapc2 Anapc1 Slc25a16 Fen1 Cul1 Anapc11 Anapc15 Anapc10 Fzr1 Gmnn G6pc E2f2 Psmb7 Psmb1 Gins3 Gins4 Gins1 Gins2 E2f1 Psma5 E2f3 LOC100911727 Cdt1 Pold2 Psma2 Pold1 Pold4 Psmc5 Psma1 Psmd2 Psma4 Psmc1 Psma3 Psmc4 Psma6 Psmc2 Psme1 Psmd1 Psme2 Psmd7 Psmd3 Psmd6 ARYL HYDROCARBON RECEPTOR SIGNALLING%REACTOME DATABASE ID RELEASE 66%10146264 Aryl hydrocarbon receptor signalling Ptges3l1 Aip Hsp90ab1 Arnt2 Arnt Ptges3 Ahr Ahrr ISG15 ANTIVIRAL MECHANISM%REACTOME DATABASE ID RELEASE 66%10145800 ISG15 antiviral mechanism LOC100912571 Stat1 Irf3 Jak1 Eif4e2 Arih1 Ddx58 Uba7 LOC100911431 Ube2l6 Eif4g1 Eif4a3 Eif4g2 Eif4g3 Flnb Isg15 Trim25 Eif2ak2 Usp18 Ube2n Ppm1b Plcg1 Eif4e3 Eif4a2 Mx1 Mx2 Eif4a1 LOC680559 GENERIC TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 66%10144749 Generic Transcription Pathway Rfc2 Gtf2h1 Gtf2h2 Usp7 Mdm2 Nrbf2 Zfp28-ps1 Zfp445 Banp Zfhx3 Notch3 Rarg Esr2 Mnat1 Rbx1 RGD1565904 Nr2c2ap Cdk5 RGD1308751 Hnf4a Polr2g Hnf4g Polr2h Zfp473 Polr2e Nr4a3 Polr2f Nr4a1 Polr2j Nr4a2 Polr2k Polr2d LOC685619 Polr2i Zfp212 Polr2b Pml Zfp418 Polr2c Zfp213 Polr2a Actl6a Zfp867 Esrra Esrrb LOC100912534 Triap1 Elf1 Ell Sumo1 Elf2 Rpa3 Tp53bp2 Nr6a1 Nr2c2 Nr2c1 Atp5c1 Cited2 Zkscan1 Tcea1 Zfp263 Pcna Zfp266 Taf7l Brca1 Zfp496 Ccnh Blm LOC102555919 Mapkapk5 Rara Pcgf2 Rarb Yap1 Zfp498 Tead2 Pidd1 Tead1 Nr2e1 Ppm1d Ube2i Hdac4 Zfp483 Nr2f6 Rbm14 Gtf2h3 Rfc5 Nr2f1 LOC100911677 Rfc4 Zfp287 Rfc3 LOC691135 Sox9 Nr2e3 Gtf2h5 Thra Zfp282 Gtf2h4 Thrb Zfp786 Smad3 Actl6b Ccnt2 Ing2 Zfp770 Smad2 Smarce1 Zfp771 Zfp354c Nr1h3 Nr1h2 Pbrm1 Tceb3 Arid1b Zfp354a Arid1a Usp9x Sp1 Zfp791 Ube2d1 Skil Zfpm1 Rbl1 Nr5a1 Cdk4 Ncor2 Cdk9 Akt1 Rora Nr1i2 E2f4 Smarcd1 LOC102554302 Hdac1 Tgif2 Smarcd2 Ercc3 Tgif1 LOC100911274 Smarcd3 Atp1b4 Nuak1 Rpa1 Brpf3 Trim33 Foxp3 Ccnd1 Rpa2 Ccnk Brpf1 Ube2d3 LOC100911822 LOC100363472 Brd1 Taf7 Nr1i3 Wwtr1 Tfdp1 Taf3 Ercc2 Kat6a Taf6 Tfdp2 Taf5 Stub1 Ing5 Zfp202 Tp53inp1 MGC114246 Zfp839 Zfp420 LOC100911519 Tbx5 Runx2 Rxrg Tp63 Nrbp1 Yaf2 Zfp426 LOC102553866 Nelfe Nelfa Nelfb Testin Znf740 Cradd Bnip3l Slc25a16 Znf750 Ssrp1 L3mbtl1 L3mbtl2 Zfp775 Zfp777 Dek Map2k6 Zfp746 Zfp583 Zfp180 Zfp189 Dyrk2 Epc1 Cul1 Zfp804b Zfp703 Tp53rk LOC100911224 Zfp707 Zfp710 Supt16h Zfp711 Krba1 Zfp566 Zfp169 Zfp167 Zfp383 Zfp37 Zfp113 Zfp110 Zfp382 Zfp112 Zfp46 Zfp398 Zfp111 Trim28 Zfp394 Zfp2 LOC100364523 Zfp317 Zfp597 Zfp74 LOC501406 Zfp9 Zfp1 Zfp84 Rslcan18 Serpinb13 Zfp90 Zim1 Zfp641 Zfp647 LOC102549842 LOC102555083 LOC102546354 Auts2 Pax5 LOC102553962 Mga Zfp668 Cdk5r1 Zfp667 Psmb7 Prelid1 Psmb1 Taf11 Ctsl Taf15 Zfp248 Esrrg Ctsm Taf13 Ctsj Taf12 RGD1564657 Ctsk Taf4b Ctsq Ctsr Nr0b1 Noc2l Nr0b2 Psma5 Max Parp1 Supt4h1 Pou4f2 Cdk7 Zfp286a Hipk1 E2f6 Zfp324 Psma2 Psmd2 Brd2 Zfp697 Zfp612 Cts8 Zfp692 Cts7 Zfp691 Psmc2 Ppp1r13b Psmd1 LOC100910137 Psmd7 RGD1564827 Ppp1r13l Zfp606 Ttc5 Zfp688 Psmd3 Rorb Psmd6 Rhno1 Bard1 Wrn Topbp1 Rbbp8 Rmi1 Rmi2 Rad50 Lhb Gata2 LOC364561 LOC100911167 Pin1 Brd7 Sesn2 Tal1 Plk2 Ldb1 Txnrd1 Ccne2 Sesn1 Plk3 RragB Ccne1 Prkab1 Tp73 Sesn3 Gata1 Prkab2 Lmo2 Gsr Lmo1 Atrip Cts8l1 Cdk2 E2f7 E2f8 Btg2 Cnot6l Cnot11 Rad1 Atr Rad17 Tgfb1 Setd8 Rad9a Tmem55b Nbn Pip4k2b Cga Rad9b Pip4k2c Mre11a Rbbp5 Hus1 Tfap2a Tnks1bp1 Cnot8 Rqcd1 Ppp2cb Cnot3 Ppp2ca Cnot1 Skp1 Cnot2 Ppp2r1a Cnot7 Cnot4 Phc1 Phc2 Mtor Prdx1 Ddit4 Rheb Prkag3 Rptor Lamtor4 LOC502894 Tfap2b Tsc1 Tfap2c Lamtor5 Sin3a Txn1 Ppp2r1b Sin3b Mlst8 Prkaa1 Tsc2 Tfap2d Rraga Tfap2e Prkaa2 Rragc Akt3 Rragd Slc38a9 Mapk14 Mapk11 Rxra Pparg Prmt5 Prmt6 Hist1h2bo Scmh1 Hist1h2bcl1 Hist2h3c2 Cbx4 Hist1h2bk Cbx2 H3f3b Smurf1 Cbx8 Cbx6 Bmi1 Hdac2 Rnf2 Mbd3 E2f5 Ring1 Smarca4 Hdac1l Chd3 Smarca2 Snw1 Chd4 Phc3 LOC100911617 Arid2 Zfp385a Smarcc1 Smarcc2 Smarcb1 Mta2 Gatad2a Cdk6 Gatad2b Meaf6 LOC100909949 Eed Atad2 LOC100910200 Ccnd3 H2afx Hist1h4b Wdr5 Kmt2a LOC684841 Smyd2 Hist1h2bh LOC100912290 Rbbp7 Hist1h2ail1 Hist1h4m LOC102549173 LOC103690002 Ehmt2 LOC100910152 Ehmt1 LOC100912338 Hist1h3c H2afb3 Hist1h3f Hist2h4 Cenpj LOC684819 Hist1h3a H2afj Hist2h2aa3 Hist1h2bq Hist2h2aa2 Ash2l LOC100364835 LOC684762 Dpy30 Cited4 Yeats4 Tcf7 Hist1h2bg Ezh2 Lef1 Tcf7l1 LOC680097 LOC684797 LOC100912418 Hist1h2ba Hist3h2bb Nr1h4 Maml1 Rbpj Kat2a Rbpjl2 Csnk2a2 Csnk2a1 LOC100909750 Vdr Hipk2 Supt5h Skp2 Cdkn1a Cdkn1b Chm Gadd45a Bax Rabggta Ppara Ppard Aurka Cdc25c Aurkb Rabggtb Abl1 G6pc Men1 Ppp2r5c Gpi Pdpk1 Psmc6 Psmb10 Psmb8 Psmb9 Psmb4 Psmb11 Psmb5 Psmf1 Psmb6 Psmd4 Psmb2 Psmd5 Psmd8 Psmd9 Psmb3 Psma8 Psmd11 Psmd12 Ccna2 Ccna1 Rffl Psmd13 Ccng1 Psmd14 Phf20 Atm Rictor Tceb2 Tceb1 Psmc3 Src Ywhah Ywhag Sfn Ywhaz Ywhab Ywhaq Ywhae Med1 Lamtor3 Cited1 Nr5a2 Gtf2f1 Gtf2f2 Lamtor2 Lamtor1 Bmyc Prmt1 Esr1 Cbfb Gata3 Crebbp Pgr Tbp Runx1 Akt2 Nr1d1 Notch1 Pcgf6 Nr1d2 Kras Pcgf5 Notch4 Cdk12 Taf2 Zfp14 Slmo1 Taf9 RGD1562871 Zfp12 Cdk13 Casp2 Zfp13 Zfp28 Zfp18 Csnk2b Usp2 Tpx2 Daxx LOC100910954 Cdk1 Mdm4 Chek2 Taf10 Rnf34 Mapkap1 Sgk1 Psmc5 Psma1 Psma4 Psmc1 Ptpn11 Psma3 Notch2 Psmc4 Psma6 Psme1 Psme2 Taf9b ACYL CHAIN REMODELING OF CL%REACTOME%R-RNO-1482798.1 Acyl chain remodeling of CL Pla2g4a Taz Lclat1 Hadha Hadhb VOLTAGE GATED POTASSIUM CHANNELS%REACTOME DATABASE ID RELEASE 66%10145837 Voltage gated Potassium channels Kcng4 Kcng3 Kcnq2 Kcna7 Kcnb2 Kcns2 Kcnq3 Kcns1 Kcnh4 Kcnh3 Kcnh2 Kcnab3 Kcna10 Kcnf1 Kcnh6 Kcnh5 Kcnd3 Kcnd1 Kcna1 Kcnab2 Kcna2 Kcna5 Kcnc3 Kcnh1 Kcna4 Kcnc2 Kcnv2 Kcnv1 Kcns3 Kcnq1 ADHERENS JUNCTIONS INTERACTIONS%REACTOME DATABASE ID RELEASE 66%10145606 Adherens junctions interactions Pvrl3 Pvrl4 PVR Cdh2 Ctnna1 Pvrl1 Cdh10 Cdh11 Pvrl2 Cdh17 Cdh13 Cdh7 Cdh9 Cdh24 Jup Cadm3 Cadm2 Ctnnd1 Cdh3 Cdh5 Cdh15 Ang2 Cdh6 Cdh1 BETA-OXIDATION OF PRISTANOYL-COA%REACTOME%R-RNO-389887.1 Beta-oxidation of pristanoyl-CoA Amacr Acot8 Acox3 Crat Hsd17b4 Acox2 Crot Acoxl SEMA4D IN SEMAPHORIN SIGNALING%REACTOME%R-RNO-400685.1 Sema4D in semaphorin signaling Rras Rock1 LOC102552659 Erbb2 Rac1 Arhgap35 Rhoa Sema4d Plxnb1 Rock2 Rnd1 Arhgef11 Rhob Rhoc TRANSCRIPTIONAL REGULATION BY E2F6%REACTOME%R-RNO-8953750.1 Transcriptional Regulation by E2F6 Eed Pcgf6 Max Bmi1 Rnf2 Mga Rbbp7 Yaf2 Ring1 E2f6 Ehmt2 Phc3 Epc1 Ehmt1 LOC100911274 Pcgf2 RGD1562871 Ezh2 L3mbtl2 Tfdp1 Phc1 Tfdp2 SUMOYLATION OF DNA DAMAGE RESPONSE AND REPAIR PROTEINS%REACTOME%R-RNO-3108214.1 SUMOylation of DNA damage response and repair proteins Nup93 Nup43 Nup98 Nup133 Nup107 Pias1 Aaas Nup210 Npap60 Stag1 Nup35 Nup37 Nupl2 Pias4 Pml Rad21 Nupl1 Pias2 Smc1a Stag2 Smc3 Tdg Scmh1 Cbx4 Cbx2 Cbx8 Sumo1 Bmi1 Rnf2 Sumo3 Ring1 Phc3 Brca1 Blm Mdc1 Pcgf2 Xpc Ube2i Nup205 Ranbp2 Nsmce1 Nsmce2 Nup155 Smc6 Smc5 Rad52 Herc2 Xrcc4 LOC100911274 Nup88 Rpa1 Nup85 Phc1 Nup153 Phc2 Parp1 Tpr Rae1 Nup54 Pom121 Nup62 ERK1 ERK2 PATHWAY%REACTOME DATABASE ID RELEASE 66%10144961 ERK1 ERK2 pathway Ereg Nrg1 Btc LOC102552659 Erbb3 Erbb2 Nrg3 Egfr Hbegf Nrg4 Fyn Ptk2 Nrg2 Shc2 Ranbp9 Pdgfa Pdgfb Tln1 Vwf Apbb1ip Rasa1 Dlg4 Grin2d Camk2g Grin2b Grin1 Nefl Rasgrf1 Dusp4 Dlg1 Dlg2 Frs3 Dlg3 Camk2d Actn2 Camk2a Dusp7 Dusp6 Fgb Ret Fgg LOC100909468 Hgf Fga Gdnf Map2k2 Pspn Ppp2r5e Il2rg G6pc Pdgfra Pdgfrb Psmb7 Psmb1 Ppp2r5c Spta1 Lrrc7 Ppp2r5a Gfra4 Gfra3 Ppp2r5b Gfra2 Pbp2 Fn1 Artn Dusp9 Dusp2 Shc3 Dusp5 Nrtn Rasal3 Psma5 Ptpra Csk Rasal1 Rasal2 Rasgrp1 Rap1a Pebp1 Ncam1 Rasgrp4 Sptbn1 Rasgrp3 Pea15 Dusp1 Mark3 Psma2 Araf Rasa4 Psmd2 Il5 Spred1 Spred2 Rasgef1a Il2 Psmc2 Rasa2 Rasa3 Itga2b Il2ra Csf2 Psmd1 Il3ra Psmd7 Nf1 Iqgap1 Kit Syngap1 Psmd3 Kitlg Il2rb Psmd6 Dusp16 Psmc6 Map3k11 Csf2ra Psmb10 Csf2rb Ksr1 Rapgef2 Psmb8 Wdr83 Psmb9 Ksr2 Raf1 Psmb4 Ppp5c Psmb11 Psmb5 Il17rd Psmf1 Il5ra Psmb6 Cnksr1 Psmd4 Cnksr2 Psmb2 Dusp10 Psmd5 Paqr3 Psmd8 Psmd9 Psmb3 Psma8 Psmd11 Psmd12 Psmd13 Psmd14 Fgf2 Psmc3 Src Ppp2cb Ppp2ca Ppp2r1a Ywhab Ppp2r1b Mapk1 Jak3 Jak1 Vcl Sptan1 Fgf23 Fgf22 Fgf4 Fgf1 Fgf3 Fgf6 Fgf5 Lamtor3 Fgf20 Fgf16 Lamtor2 Fgf17 Irs2 Fgf10 Fgf9 Fgfr2 Fgf7 Fgf8 Fgfr3 Fgfr1 Fgfr4 Fgf19 Erbb4 Irs1 Frs2 Tyk2 Kras Il6st Il6 Cdk1 Psmc5 Arrb1 Psma1 Tek Psma4 Psmc1 Arrb2 Ptpn11 Psma3 Psmc4 Psma6 Lat Psme1 Angpt1 Hras Psme2 Nras Sos1 Shc1 Grb2 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE%REACTOME DATABASE ID RELEASE 66%10145153 Toll Like Receptor 9 (TLR9) Cascade Map2k7 Ripk2 Map2k6 Ager Dusp3 Map2k4 Map3k8 Dusp4 Peli3 Nfkbib LOC100912399 Peli2 Map3k1 Traf6 Cul1 Vrk3 Rps6ka2 Rps6ka1 App Rps6ka3 Rps6ka5 Tlr9 LOC100912585 Tab1 Dusp7 Dusp6 Rela Atf1 Atf2 Map3k7 Peli1 Irak2 Nfkbia LOC100910771 Ube2n Rbsn Jun Ppp2cb Ppp2ca Skp1 Ppp2r1a Nfkb2 Nfkb1 Mapk9 Tlr7 Mapk8 Tlr8 Fos S100b Irak4 Pik3c3 Mapk7 Dhx9 Fbxw11 Chuk Ppp2r1b Ecsit Mapkapk3 Pik3r4 Eea1 Btrc Mapkapk2 Dhx36 Mapk1 Nkiras1 LOC100362142 Nod1 Nod2 Nkiras2 Creb1 Tab2 Tab3 LOC100912618 Ube2v1 Ikbkb Mapk14 Myd88 Tnip2 Mapk11 Mapk10 GLUCAGON SIGNALING IN METABOLIC REGULATION%REACTOME DATABASE ID RELEASE 66%10145003 Glucagon signaling in metabolic regulation Prkaca Prkacb Prkar2b Prkar2a Prkar1b Gcgr Gcg Prkar1a ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION%REACTOME DATABASE ID RELEASE 66%10145786 Antigen processing: Ubiquitination & Proteasome degradation Rnf41 Vhl Asb18 Asb11 Asb12 Rbx1 Asb13 Asb14 Asb10 Socs3 Uba7 Keap1 Traf7 Glmn Asb15 Uba5 Asb17 Hecw2 Asb16 Ube2l6 Rbbp6 Ube3d Ube3b Trim11 Lrsam1 Ube3a Npepps Ube2o Rbck1 Ube2u Hectd3 Hectd1 Rnf6 Rnf4 Traip Rnf25 Anapc13 Lnx1 Rnf19a Rnf19b Herc3 Arih2 Ube2v2 Herc6 Ube2n Tpp2 Ubox5 Ube2j2 Arel1 Ube2j1 Rnf182 Rnf14 Ltn1 Cblb Sh3rf1 Pja1 Pja2 LOC100911393 Dtx3l Znrf2 Znrf1 Trim9 Blmh LOC100911400 Rnf115 Trim63 Ube2d1 Dzip3 Trip12 Ubr2 Trim71 Vprbp Trim69 Trim39 Ube4a Herc2 LOC100910646 Ufl1 Trim50 Ubac1 Ube2q1 Thop1 Rlim Ube2d3 Mex3c Rchy1 Mgrn1 Trim41 Hace1 Trim36 Trim37 Stub1 Anapc7 Cdc26 Cdc27 Fbxl22 Cdc23 Rnf144b Lrrc41 Ube2c Skp2 Fbxw10 Fbxw12 Cdc16 Anapc4 Anapc2 Anapc1 Trim21 Trim32 Cul1 Wwp1 Atg7 Anapc11 Anapc10 Fzr1 Siah1 Siah2 G6pc Klhl5 Cdc20 Psmb7 Psmb1 Klhl2 Fbxo2 Fbxo9 Fbxo7 Fbxo6 Psma5 Fbxo4 Ube2k Ube2h Ube2f Ube2a Psma2 Psmd2 Klhl9 Psmc2 Psmd1 Lrr1 Psmd7 Psmd3 Psmd6 Psmc6 Psmb10 Psmb8 Psmb9 Rnf123 Psmb4 Psmb11 Fbxl19 Psmb5 Psmf1 Fbxl12 Psmb6 Fbxl13 Psmd4 Psmb2 Fbxl16 Fbxl15 Psmd5 Psmd8 Psmd9 Psmb3 Psma8 Psmd11 Ccnf Psmd12 Ube2e3 Psmd13 Psmd14 Tceb2 Ube2z Tceb1 Cul2 Ube2s Psmc3 Fbxl4 Fbxl5 Fbxl8 Kctd7 Rnf7 Skp1 Kbtbd8 Kbtbd7 Kbtbd6 Kctd6 Ube2q2 Ube2r2 Fbxw11 Btrc Gan LOC100362142 LOC100912618 Ube2v1 Fbxl18 Fbxl7 Asb5 Asb6 Asb7 Klhl41 Asb1 Asb3 Cdc34 Asb8 Klhl42 Smurf1 Ube2m Fbxo41 Fbxo44 Fbxo40 Wsb1 Spsb2 Spsb1 Ubr4 Spsb4 Btbd1 Btbd6 Fbxo22 Ube2g2 Ube2g1 Klhl13 Fbxo30 Fbxo31 Klhl11 Fbxo32 Fbxo21 Klhl20 Zbtb16 Klhl25 Klhl21 Uba1 Klhl22 Fbxo10 Socs1 Fbxo15 Fbxo11 Fbxw2 Mylip Uba6 Rnf34 Psmc5 Fbxw9 Uba3 Psma1 Psma4 Psmc1 Fbxw5 Psma3 Fbxw4 Psmc4 Fbxw8 Psma6 Fbxw7 Psme1 Psme2 LOC100909844 GAP JUNCTION TRAFFICKING%REACTOME%R-RNO-190828.1 Gap junction trafficking Gja1 Gja5 Dnm1 Gjd4 Gja3 Gja8 Gja4 Gjb6 Gjb2 Cltc Gja10 Cltb Gjd2 Gjb3 Clta Dnm2 Gjb4 Gjc1 Gjc2 Gjb1 Myo6 Dab2 Ap2m1 REGULATION OF PTEN STABILITY AND ACTIVITY%REACTOME DATABASE ID RELEASE 66%10146185 Regulation of PTEN stability and activity Psmc6 Pten Psmb10 Trim27 Otud3 Psmb8 Psmb9 Psmb4 Psmb11 Psmb5 Psmf1 Psmb6 Psmd4 Psmb2 Psmd5 Psmd8 Csnk2a2 Psmd9 Psmb3 Psma8 Psmd11 Csnk2a1 Psmd12 Psmd13 Psmd14 Usp13 Prex2 Psmc3 Tnks2 LOC100910717 Akt2 G6pc Akt1 Frk Psmb7 Psmb1 Xiap Tnks Stub1 Csnk2b Psma5 Psma2 Psmc5 Akt3 Psmd2 Psma1 Psma4 Psmc1 Psma3 Psmc4 Psmc2 Psma6 Psme1 Psmd1 Psme2 Psmd7 Psmd3 Psmd6 EXTRINSIC PATHWAY OF FIBRIN CLOT FORMATION%REACTOME DATABASE ID RELEASE 66%10145054 Extrinsic Pathway of Fibrin Clot Formation Tfpi F3 F7 F9 MITOCHONDRIAL TRANSLATION ELONGATION%REACTOME DATABASE ID RELEASE 66%10146063 Mitochondrial translation elongation Mrps11 Mrps12 Mrps16 Mrps14 Mrps18b Mrps18c Mrps10 Mrps18a Mrps33 Mrps34 Mrps21 Mrps35 Mrps17 Mrps15 Mrps31 Mrps30 Mrps24 Mrps23 Mrps22 mrpl9 Mrps28 Mrps27 Mrps26 Mrps25 Mrpl4 Mrpl3 Mrpl2 Oxa1l LOC367117 Mrpl1 Mrpl13 Mrpl10 Mrpl18 Mrpl19 Mrps9 Mrps2 Mrps5 Mrps7 Mrpl36 Mrpl37 Mrpl20 Mrpl14 Mrpl16 Mrpl12 Mrpl15 Mrpl41 Mrpl35 Mrpl40 Mrpl33 Mrpl34 Mrpl38 Mrpl32 Mrpl27 Mrpl23 Mrpl28 Mrpl30 Mrpl21 Mrpl54 Mrpl46 Mrpl55 Mrpl44 Mrpl43 Mrpl47 Mrpl49 Mrpl53 Mrpl48 Mrpl52 Mrpl51 Mrpl50 mrpl11 mrpl24 Chchd1 Dap3 Eral1 Gadd45gip1 Ict1 Ptcd3 Gfm1 TRANSFER OF LPS FROM LBP CARRIER TO CD14%REACTOME%R-RNO-166020.1 Transfer of LPS from LBP carrier to CD14 Cd14 Lbp ENOS ACTIVATION AND REGULATION%REACTOME%R-RNO-203765.1 eNOS activation and regulation Nosip Nos3 Dnm2 Ddah2 Zdhhc21 Nostrin Ddah1 Wasl Spr Cygb LOC103692716 Akt1 G2 M TRANSITION%REACTOME%R-RNO-69275.1 G2 M Transition Psmc6 Psmb10 Psmb8 Psmb9 Psmb4 Psmb11 Psmb5 Psmf1 Psmb6 Mnat1 Psmd4 Rbx1 Psmb2 Dync1i2 Psmd5 Psmd8 Cep57 Psmd9 Psmb3 Rab8a Psma8 LOC691918 Psmd11 Psmd12 Haus3 Ccna2 Ccna1 Psmd13 Ninl Psmd14 Akap9 Ccp110 Cdk2 Pafah1b1 Ppp1r12a Psmc3 Ccnh Ajuba Hsp90ab1 Tubb5 Ppp2cb Ppp2ca Ywhag Skp1 Ppp2r1a Ywhae Fbxw11 Cdkn1a Ppp2r1b Nek2l1 Btrc Prkaca Nek2 Ppp2r3b Bora Fbxl18 Fkbpl Fbxl7 Ppme1 Foxm1 Cul1 Lcmt1 Tubgcp2 Aurka Dync1h1 Cdc25c LOC103692716 Ppp1cb Xpo1 Dctn1 Cntrl Dctn2 Cep76 G6pc Pcm1 Cep78 LOC100911033 Cep164 Dctn3 Ofd1 Cep41 Psmb7 Sdccag8 Psmb1 Prkar2b Cenpj Plk4 LOC100912076 Tubg2 Haus2 Psma5 Haus1 Haus5 Tpx2 Alms1 Cdk11b Clasp1 Haus4 Odf2 Cdk7 LOC100910954 Tubb4a Cdk1 Ssna1 Tubg1 Mapre1 Psma2 Cep63 Csnk1d Psmc5 Gtse1 Cep131 Psmd2 Psma1 Phlda1 Tuba4a Psma4 Cdc25b Cep250 Psmc1 Cdc25a Psma3 Cep135 Wee1 Csnk1e Psmc4 Pkmyt1 Cdk5rap2 Psma6 Psmc2 Ckap5 Ppp2r2a Psme1 Nme7 Tubgcp5 Pcnt Tubgcp6 Psme2 Psmd1 Cep72 Tubgcp3 Sfi1 Psmd7 Tubgcp4 Cep70 Optn Actr1a LOC100909844 Mzt1 Nedd1 Psmd3 Mzt2b Psmd6 SYNTHESIS OF GDP-MANNOSE%REACTOME DATABASE ID RELEASE 66%10145672 Synthesis of GDP-mannose Mpi Pmm2 Pmm1 PI-3K CASCADE:FGFR3%REACTOME DATABASE ID RELEASE 66%10145257 PI-3K cascade:FGFR3 Gab1 Fgf16 Fgf17 Pik3r1 Fgf9 Fgf2 Fgf8 Fgfr3 Fgf23 Fgf4 Ptpn11 Fgf1 Fgf5 Frs2 Fgf20 Grb2 PAOS OXIDISE POLYAMINES TO AMINES%REACTOME DATABASE ID RELEASE 66%10145060 PAOs oxidise polyamines to amines Smox RGD1564480 Paox DOWNREGULATION OF ERBB4 SIGNALING%REACTOME DATABASE ID RELEASE 66%10145828 Downregulation of ERBB4 signaling Wwp1 Erbb4 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION%REACTOME%R-RNO-2029482.1 Regulation of actin dynamics for phagocytic cup formation Abi1 Myo1c Abi2 Potef Rac1 Myh9 Nck1 Arpc1b LOC100909750 Actb Cyfip1 Brk1 LOC103692716 Baiap2 Limk1 Nf2 Pak1 Wasl Nckap1l Ptk2 Actg1 Cyfip2 Abl1 Nckap1 Fcgr3a Wasf1 Arpc4 LOC100909609 Hsp90ab1 Arpc3 Nckipsd LOC100361457 Myo9b Vav2 Vav1 Actr3 Was Fcgr1a Cd247 Actr2 Myo10 Crk Vav3 Mapk1 Cdc42 LOC100911597 Cd3g Arpc5 Dock1 Fcgr2b Wipf1 LOC103693683 Wipf2 Elmo2 Wipf3 Fcgr2a Syk Grb2 TERMINAL PATHWAY OF COMPLEMENT%REACTOME DATABASE ID RELEASE 66%10145210 Terminal pathway of complement Clu C6 C8g C8a C8b REGULATION OF RUNX1 EXPRESSION AND ACTIVITY%REACTOME%R-RNO-8934593.1 Regulation of RUNX1 Expression and Activity Ccnd3 Ptpn11 Cbfb Ccnd1 Pml Cdk6 Runx1 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%R-RNO-2514859.1 Inactivation, recovery and regulation of the phototransduction cascade Cnga1 Gucy2f Pde6b Rcvrn Gucy2d Pde6a Rgs9 RGD1560341 Gnb5 Guca1b Ppef1 Metap2 Metap1 Gnat1 Nmt1 Guca1a Cngb1 Rgs9bp Fnta Nmt2 Sag Grk4 Grk1 Gngt1 Fntb Pde6g GENERATION OF SECOND MESSENGER MOLECULES%REACTOME DATABASE ID RELEASE 66%10145400 Generation of second messenger molecules Was Cd247 Cd101 Fyb Cd3g Cd3e Nck1 Cd3d Pak2 RT1-Ba Pak3 RT1-Bb Lat Pak1 RT1-Da Cd4 Plcg1 RT1-Db2 RT1-Db1 LOC688090 Lcp2 Itk MITOCHONDRIAL TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 66%10145119 Mitochondrial transcription termination Mterf CLEAVAGE OF THE DAMAGED PYRIMIDINE%REACTOME%R-RNO-110329.1 Cleavage of the damaged pyrimidine Tdg Neil1 Ogg1 Neil2 Mbd4 Smug1 Ung Nthl1 INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME DATABASE ID RELEASE 66%10145016 Intrinsic Pathway for Apoptosis Gzmbl1 Gzmc LOC100911163 Gzmbl2 Gzmbl3 Bak1 Gzmb LOC691695 Diablo Ywhah Bcl2l11 Ywhag Sfn Ywhaz Ppp3r1 Bcl2 Bid LOC100360940 Xiap Ywhab Ywhaq Ywhae Casp8 Bad Mapk8 Dynll2 Nmt1 Bax Bmf Pmaip1 PHASE 3 - RAPID REPOLARISATION%REACTOME%R-RNO-5576890.1 Phase 3 - rapid repolarisation Kcne3 Kcnq1 Kcne5 Kcnh2 Akap9 Kcne1 Kcne2 Kcne4 TRANSLESION SYNTHESIS BY POLH%REACTOME%R-RNO-110320.1 Translesion Synthesis by POLH Rfc1 Rfc2 Rpa3 Polh Pcna Vcp Rpa1 Rpa2 Rchy1 Sprtn Rfc5 Nploc4 Rfc4 Ufd1l Rfc3 PLATELET CALCIUM HOMEOSTASIS%REACTOME%R-RNO-418360.1 Platelet calcium homeostasis P2rx1 Atp2b4 Sri Atp2b2 Atp2b1 Slc8a3 P2rx2 P2rx3 Itpr1 P2rx5 P2rx6 Itpr3 P2rx4 Trpc3 Trpc7 Atp2a2 Slc8a2 Trpc6 Slc8a1 P2rx7 Atp2a3 NUCLEAR ENVELOPE REASSEMBLY%REACTOME%R-RNO-2995410.1 Nuclear Envelope Reassembly Vrk2 Vrk1 DAG AND IP3 SIGNALING%REACTOME%R-RNO-1489509.1 DAG and IP3 signaling Prkcd Pde1b Adcy8 Adcy9 Adcy5 Adcy4 Adcy7 Adcy6 Prkar1b Prkar1a Prkaca Prkacb Adcy3 Prkar2b Prkca Prkar2a Camk4 Adrbk1 ION INFLUX EFFLUX AT HOST-PATHOGEN INTERFACE%REACTOME%R-RNO-6803544.1 Ion influx efflux at host-pathogen interface Slc11a1 Pdzd11 Atp7a Atox1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER%REACTOME DATABASE ID RELEASE 66%10146143 Gap-filling DNA repair synthesis and ligation in GG-NER Rfc1 Rfc2 Rpa3 Pole2 Pole4 Pole Pold2 Pcna Pold1 Pold4 Rpa1 Rpa2 Rfc5 Rfc4 Rfc3 PYRIMIDINE CATABOLISM%REACTOME%R-RNO-73621.1 Pyrimidine catabolism Nt5c1a Nt5c Nt5c3a Nt5e Upp1 Upb1 Upp2 Nt5m Tymp Dpys GLYCOLYSIS%REACTOME DATABASE ID RELEASE 66%10144768 Glycolysis Nup93 Nup43 Nup133 Nup98 LOC100911625 Nup107 Eno3 Aaas Gapdhs Eno1 Eno2 Nup210 Aldoa Npap60 Nup35 Aldob Aldoc Nup37 Nupl2 Gckr Nupl1 Pklr Pfkfb3 Pfkfb4 Pfkfb1 Pfkfb2 Pfkl Pfkp Nup205 Aldoart2 Ranbp2 Hk2 Pgm2l1 Nup155 Tpi1 Gpi Nup88 Nup85 Pgk2 Nup153 Pgk1 Pkm Tpr Pgam1 Pgam2 Rae1 Gnpda2 Adpgk Nup54 Pom121 Bpgm Nup62 MOLECULES ASSOCIATED WITH ELASTIC FIBRES%REACTOME DATABASE ID RELEASE 66%10145882 Molecules associated with elastic fibres Itgb6 Itgb8 LOC102553715 Vtn Itga8 Efemp1 Efemp2 Fbln2 LOC100911714 Fbln1 Fbln5 Mfap2 Gdf5 Ltbp3 Ltbp2 Mfap5 Ltbp4 Mfap4 Ltbp1 Bmp2 Bmp7 Bmp4 Mfap3 Tgfb2 Tgfb1 Tgfb3 OXIDATIVE DEMETHYLATION OF DNA%REACTOME DATABASE ID RELEASE 66%10146048 Oxidative demethylation of DNA Tdg TRANSPORT OF CONNEXONS TO THE PLASMA MEMBRANE%REACTOME%R-RNO-190872.1 Transport of connexons to the plasma membrane Gja1 Gjb2 RRNA PROCESSING%REACTOME DATABASE ID RELEASE 66%10146163 rRNA processing Rps20 Rps27l LOC100360573 Rps4x LOC100359951 LOC100359593 LOC100359503 LOC100362640 Rps3 Rps15a Rps2 Rps13 Rps12 LOC100911372 LOC100361854 LOC684988 LOC103689992 Rps5 Rps7 Rps6 LOC100362830 LOC100363012 LOC100362149 Exosc3 Exosc9 LOC100359574 Exosc2 Exosc1 Exosc4 Exosc7 Exosc5 Dcaf13 Tbl3 Tsr1 Emg1 Wdr75 Wdr18 Wdr43 Wdr46 Nhp2l1 C1d Nob1 Fcf1 Wdr12 Senp3 Wdr36 Ebna1bp2 Rpp25 Riok3 Riok1 Utp14a Bysl NEWGENE_1564769 Rpp21 Pdcd11 Rpp40 Skiv2l2 Heatr1 Riok2 Rpp38 Rrp36 Rpp30 Bop1 Utp20 Dhx37 Utp18 Gnl3 Utp15 Utp11l Pno1 Pwp2 Wbscr22 Mphosph6 Imp4 Imp3 Nop56 Tex10 Utp6 Rcl1 Nol6 Utp3 Ncl Nop14 Xrn2 Rrp9 Rrp7a Pes1 Exosc10 Krr1 Nol9 Mphosph10 LOC100910568 Rpp14 Cirh1a Diexf Nop58 Ddx52 Rps16 Ltv1 Wdr3 Noc4l Ddx49 Ddx47 Las1l Fbl Rps18 LOC100360679 Rps15 Ddx21 Rps3a Csnk1d Csnk1e AGMATINE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 66%10145466 Agmatine biosynthesis Agmat MUSCARINIC ACETYLCHOLINE RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145559 Muscarinic acetylcholine receptors Chrm1 Chrm5 Chrm2 Chrm4 Chrm3 ACTIVATED NTRK2 SIGNALS THROUGH PLCG1%REACTOME%R-RNO-9026527.1 Activated NTRK2 signals through PLCG1 Ntf4 Ntrk2 Bdnf Plcg1 KETONE BODY METABOLISM%REACTOME DATABASE ID RELEASE 66%10144854 Ketone body metabolism Hmgcll1 Aacs Bdh2 Acat1 Hmgcs2 Hmgcl Acss3 Oxct1 TYPE II NA+ PI COTRANSPORTERS%REACTOME DATABASE ID RELEASE 66%10145628 Type II Na+ Pi cotransporters Slc34a1 Slc34a3 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY%REACTOME DATABASE ID RELEASE 66%10145795 TRAF3-dependent IRF activation pathway Irf3 Crebbp ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX%REACTOME%R-RNO-68867.1 Assembly of the pre-replicative complex Psmc6 Psmb10 Psmb8 Psmb9 Psmb4 Psmb11 Psmb5 Psmf1 Psmb6 Psmd4 Psmb2 Psmd5 Psmd8 Psmd9 Psmb3 Psma8 Psmd11 Psmd12 Psmd13 Psmd14 Mcm2 Mcm4 Mcm3 Mcm5 Mcm6 Psmc3 Mcm8 Mcm7 Orc4 Orc5 Orc6 Orc1 Orc2 Orc3 Cdc6 Gmnn G6pc E2f2 Psmb7 Psmb1 E2f1 Psma5 E2f3 Cdt1 Psma2 Psmc5 Psmd2 Psma1 Psma4 Psmc1 Psma3 Psmc4 Psmc2 Psma6 Psme1 Psme2 Psmd1 Psmd7 Psmd3 Psmd6 SYNTHESIS OF PC%REACTOME DATABASE ID RELEASE 66%10145452 Synthesis of PC Chat Stard10 Ache Slc44a4 Cept1 Slc44a5 Slc44a3 Csnk2a2 Pctp Csnk2a1 Stard7 Chka Mfsd2a Csnk2b Phospho1 Lpcat1 Slc44a2 Pcyt1b Pcyt1a Lpin2 Pemt Lpin3 Abhd3 Lpin1 Bche HYALURONAN UPTAKE AND DEGRADATION%REACTOME%R-RNO-2160916.1 Hyaluronan uptake and degradation Cd44 Slc9a1 Stab2 Lyve1 Hexb Hexa Gusb Hyal1 Hyal2 Chp1 SIGNALING BY NOTCH1%REACTOME DATABASE ID RELEASE 66%10145913 Signaling by NOTCH1 Notch1 Dtx2 Dtx4 Maml1 Rbpj Crebbp Kat2a Snw1 Rbpjl2 Dtx1 PASSIVE TRANSPORT BY AQUAPORINS%REACTOME DATABASE ID RELEASE 66%10145707 Passive transport by Aquaporins Aqp7 Aqp11 Aqp4 Mip Aqp12a Aqp1 NCAM1 INTERACTIONS%REACTOME DATABASE ID RELEASE 66%10145505 NCAM1 interactions Col4a2 Col9a1 Col9a2 Col9a3 Col4a1 Ncam1 LOC501189 St8sia4 SIALIC ACID METABOLISM%REACTOME DATABASE ID RELEASE 66%10145633 Sialic acid metabolism St8sia1 Neu4 Neu2 St8sia3 Neu3 Neu1 St3gal5 Ctsa Nans Slc35a1 St8sia5 Slc17a5 St6galnac1 St6galnac2 Npl LOC501189 Cmas St8sia4 Nanp St6gal1 St6gal2 Glb1 St3gal2 St6galnac4 St3gal3 St6galnac3 Gne St3gal1 St6galnac6 St3gal4 St3gal6 G1 S DNA DAMAGE CHECKPOINTS%REACTOME DATABASE ID RELEASE 66%10144740 G1 S DNA Damage Checkpoints Psmc6 Psmb10 Mdm2 Psmb8 Psmb9 Psmb4 Psmb11 Psmb5 Psmf1 Psmb6 Psmd4 Psmb2 Psmd5 Psmd8 Psmd9 Psmb3 Psma8 Psmd11 Psmd12 Ccna2 Ccne2 Ccna1 Psmd13 Psmd14 Ccne1 Phf20 Atm Cdk2 Psmc3 Zfp385a Rfwd2 G6pc Psmb7 Psmb1 Psma5 Cdkn1a Cdkn1b LOC100910954 Mdm4 Chek2 Psma2 Psmc5 Psmd2 Psma1 Psma4 Psmc1 Cdc25a Psma3 Psmc4 Psmc2 Psma6 Psme1 Psmd1 Psme2 Psmd7 Psmd3 Psmd6 SODIUM-COUPLED PHOSPHATE COTRANSPORTERS%REACTOME DATABASE ID RELEASE 66%10145627 Sodium-coupled phosphate cotransporters Slc20a2 Slc34a1 Slc34a3 Slc20a1 REGULATION OF COMMISSURAL AXON PATHFINDING BY SLIT AND ROBO%REACTOME DATABASE ID RELEASE 66%10145632 Regulation of commissural axon pathfinding by SLIT and ROBO Robo2 Robo3 Robo1 REGULATION OF PTEN LOCALIZATION%REACTOME%R-RNO-8948747.1 Regulation of PTEN localization Pten Usp7 Pml Xiap PHASE II - CONJUGATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 66%10144773 Phase II - Conjugation of compounds Bpnt1 Slc35b2 Abhd14b Nat1 Glyatl3 Nat2 Acsm1 Sult6b1 Podxl2 Glyat Sult4a1 Slc35b3 Sult2a1 Nat3 Gstm7 Ggct Esd Gclm Gstm5 Gsto2 Gstk1 Cndp2 Gclc LOC100912430 Gstt2 Ggt7 Ggt6 Chac2 Chac1 Mgst3 Oplah LOC100910526 RGD1562392 Hpgds ste2 Impad1 Tpst1 Tpst2 Sult2b1 NEWGENE_1306455 LOC100910057 Comt Sult1b1 Mat1a LOC100910881 Sult1a1 Mat2b Sult1c2 Mgst1 LOC100363915 Ahcy N6amt1 Ugt2b Ugt1a8 Nnmt Mat2a Ugt2b37 Ugt1a9 As3mt Ugt1a6 Tpmt Gstp1 Ugt2b35 Mtrr Ugt2a1 Trmt112 Gsto1 Ugt2b15 Ugp2 Mtr Ugt1a1 Ugt2b17 RGD1559459 Ugt1a7c Papss2 Ugt1a5 Papss1 Ugt1a3 Ugt1a2 Ugdh Gstz1 Slc35d1 Gsta5 Gss Akr1a1 Gstm4 Slc26a2 Slc26a1 Cyp1a2 TRANSFERRIN ENDOCYTOSIS AND RECYCLING%REACTOME%R-RNO-917977.1 Transferrin endocytosis and recycling Atp6v1d Tcirg1 Atp6v0d1 Atp6v1c2 Tfrc Atp6v0d2 Tf Atp6v1a Atp6v0e2 Atp6v0e1 Atp6ap1 Atp6v1g3 Atp6v1e1 Atp6v1e2 Atp6v1c1 Atp6v1g1 Atp6v1g2 Atp6v0a4 Atp6v0a1 Atp6v1b2 Atp6v0a2 Atp6v1h Atp6v1f Tfr2 Hfe Steap2 Atp6v0c Mcoln1 NECTIN NECL TRANS HETERODIMERIZATION%REACTOME DATABASE ID RELEASE 66%10145613 Nectin Necl trans heterodimerization Pvrl3 PVR Pvrl4 Pvrl1 Pvrl2 Cadm3 REGULATION OF FZD BY UBIQUITINATION%REACTOME DATABASE ID RELEASE 66%10146037 Regulation of FZD by ubiquitination Lrp5 Lrp6 Wnt3 Rnf43 Fzd4 Fzd6 Rspo1 Lgr4 Lgr6 Lgr5 Rspo4 Wnt3a Usp8 Rspo2 Rspo3 FGFR3B LIGAND BINDING AND ACTIVATION%REACTOME%R-RNO-190371.1 FGFR3b ligand binding and activation Fgf1 Fgf17 Fgf9 Fgf8 Fgfr3 Fgf20 ION HOMEOSTASIS%REACTOME DATABASE ID RELEASE 66%10145041 Ion homeostasis Fxyd2 Camk2g Fxyd3 Fxyd4 Atp2b4 Stim1 Dmpk Atp2b2 Sri Atp2b1 Sln Tnni3 Camk2d Camk2a Clic2 Trdn Atp2a2 Fxyd6 Pln Fxyd7 Nos1 Atp2a3 Atp1b3 Atp1b2 Atp1b1 Fkbp1b Ryr2 Slc8a3 Prkaca Kcnj11 Itpr1 Ahcyl1 Itpr3 Atp1a4 Atp1a1 Slc8a2 Atp1a2 Slc8a1 Atp1a3 Abcc9 DEVELOPMENTAL BIOLOGY%REACTOME DATABASE ID RELEASE 66%10144967 Developmental Biology LOC102552659 Erbb2 Egfr Kif4a Cdk5 Dnm2 Actb Fyn Ephb1 Ephb2 Ephb4 Ephb3 Efnb2 Efnb1 Efnb3 Myl12a Nck2 Smad3 Smad2 Ranbp9 Akt1 Foxo1 Foxo3 Kdr Adam11 Stx1a Cacng8 Prkca Cacng2 Lyn Cacng3 Lgi4 Yes1 Cacng4 Lgi3 Rhob Stx1b Lgi1 Dlg4 Rhoc Adam23 Krt10 Tgm1 Krt13 LOC100910942 LOC690386 Dsg4 Grin2b Krt19 Klk8 Grin1 Krt18 Dsg3 Krt15 Dsg2 Krt14 Dsc3 Krt17 Ivl Mmp9 Krt16 Spink5 Dsc2 RGD1561281 Krt33b Spink6 Krt33a LOC684499 LOC100363184 LOC100910851 Rptn LOC680396 Mmp2 Krtap3-3 LOC100911681 Lipk Krtap3-1 Lipm Krtap4-5 Krt9 LOC100360690 LOC689230 Krt7 Krtap4-7 Stfa2l1 Rps6ka5 Krt2 Stfa2l3 Krt8 Stfa2l2 LOC100910814 LOC100912585 Krt4 Krtap4-13 LOC680160 Krtap11-1 LOC100363136 LOC100909618 LOC687631 Krtap12-2 LOC100365646 LOC689927 Krt75 Krtap8-1 Krt71 Ptprc Krtap24-1 Krt77 Col9a1 Krt73 Col9a2 Krt72 Col9a3 Prkcq Krtap1-1 Sdcbp Krt40 Cd72 Col4a1 Krt76 Siah1 Krtap1-3 Ret Krtap13-2 Krtap27-1 Siah2 Krtap1-5 Krtap14l Krt28 Dpysl2 LOC100361664 Dpysl5 Krt24 Dpysl4 Krt23 LOC100910964 Krt31 Fes Sh3gl2 Col4a2 Krt25 Nrcam Krt26 Gdnf Krt27 Reln Sh3kbp1 LOC690460 Rnd1 Krt35 Plxnd1 Krt34 Ntn1 Dag1 Krt32 Pdlim7 LOC690478 Ntn4 Krtap3-3l1 Map2k2 Krt39 Pspn Krt36 Dpysl3 Crmp1 Rras Ank1 Arhgef7 Plxna2 Plxna1 Rock1 Gap43 Sema7a Rdx LOC103692570 Rap1gap Sema6d Cdk5r1 Itsn1 Epha10 Dcc Farp2 Sema5a L1cam Ezr Kb23 Trem2 Krtap9-1 Spta1 Kalrn Gfra4 Sema4d Plxnb1 Gfra3 LOC100912512 Gfra2 Dok4 Krt81 Dok1 Krt80 Vav2 Dok6 Krtap26-1 Dok5 Krt82 Krt84 Arhgef11 Sema3a Krt83 Sema3e Efna2 Krt86 Dsp Efna1 Krt85 Artn Efna4 Shc3 Nrtn Ptpra Tiam1 Dnm1 Dab1 Vav3 Dnm3 RGD1565682 Epha4 Ncam1 Sptbn1 Epha5 Pkp1 Lypla2 Msn Ngef Epha7 Epha8 Pkp4 Epha3 Pkp3 Epha2 Sprr3 Klk12 Epha1 Klk13 Klk14 Stfa3l1 Casp14 Itga2b Stfa3 Evpl Csta LOC100911797 Ppl Perp Cela2a LOC100362978 Aph1b Psenen Aph1a LOC100911293 Psen2 Psen1 Ncstn Pik3r3 Mapk8 Vldlr Mapk7 Mapk1 Akt3 Creb1 Mapk14 Mapk11 Rxra Pparg Cdon Boc Cxcl12 Robo2 Robo3 Akap5 Enah Myo9b Vasp Abl2 Robo1 Cxcr4 Usp33 Slit3 Slit2 Plcg1 Potef Csnk2a2 Nck1 Csnk2a1 Rock2 Arpc1b LOC100909750 LOC100909840 Ptk2 Actg1 LOC100909609 Nrp1 Pik3cd Tln1 Vegfa Dock1 Gpc1 Rasa1 Shb Arhgef28 Pip5k1c Evl Limk1 Pak2 Pak3 Pak1 Wasl Abl1 Arpc4 Arpc3 LOC100361457 Actr3 Cdh2 Ctnna1 Mapk13 Mapk12 Dscaml1 Dscam Cdc42 Pfn1 Pfn2 Rac1 Arhgap35 Sdc2 Ap2a2 Src Hsp90ab1 Cltc Clta Ap2s1 LOC100912586 LOC100363287 Krtap15-1 Ap2a1 Ap2m1 Prkaca Prkacb Myf5 Myf6 Tcf4 Myog Sptan1 Gab1 Irs2 Foxh1 LOC103692716 Fgfr1 Grb10 Myod1 Mef2c Spag9 Frs2 Cdh15 Mef2a Akt2 Drap1 Kras Grb7 Dok2 Pik3r1 Pik3r2 Jup Nfasc Tyrobp Dsg1 Csnk2b Actr2 LOC501189 St8sia4 Pik3cb Ptpn11 Rhoa Arpc5 Hras Nras Sos1 Shc1 Grb2 GPCR DOWNSTREAM SIGNALLING%REACTOME DATABASE ID RELEASE 66%10144869 GPCR downstream signalling Plcb1 Plcb3 Ffar1 Gnaq Gna11 Gna14 Gna15 Plcb4 Gnai3 Akt1 Gnao1 Chrm4 Gnat2 Gnaz Rhob Rhoc Rps6ka2 Rps6ka1 App Rps6ka3 LOC100912585 Rock1 C5ar1 Tshb Gnal Gnat3 Grp Ppp2cb Ffar4 Ppp2ca Ppp2r1a Mapk7 Ppp2r1b Mapk1 Adora3 Creb1 Adora2a Adora2b LOC100911796 LOC100363178 Adora1 LOC100365814 Lrp1 Gpr39 Olr663 Olr660 Olr561 Olr1024 Olr560 LOC100910009 Olr158 Cnga1 Olr557 LOC100910335 Gucy2f Pde6b Olr164 Rcvrn Olr659 Olr160 Gucy2d Pde6a Olr657 Rgs9 Olr662 RGD1560341 Olr664 Olr1868 Olr1199 Gpr27 Olr653 LOC100910402 Olr651 Olr650 Olr294 LOC100911909 Olr544 Olr1197 Olr1196 Olr1195 Olr1194 Olr1198 LOC100910409 Olr1128 LOC100911893 LOC100910928 Olr323 Olr119 Olr1126 LOC100912097 Olr1125 Olr420 Olr217 Olr1121 Olr1122 Olr1129 Olr322 Olr214 Gpr84 Olr215 Olr414 Guca1b Ppef1 Olr1512 Kng1l1 Metap2 Olr1513 Metap1 Olr416 Olr556 Gnat1 Nmt1 Gpr150 Olr1511 Guca1a Cngb1 Olr413 Olr1517 Rgs9bp Olr319 Fnta Olr120 Nmt2 Olr321 Sag Olr1514 Grk4 LOC100911380 Grk1 Fntb Olr417 Olr418 Pde6g LOC100910041 Olr259 Olr1163 Olr1166 LOC684208 Olr127 Olr530 Olr126 Olr931 Olr674 Olr129 Olr532 Olr1174 Olr670 Gpr45 Olr675 Olr892 Olr247 Olr1156 Olr190 Olr194 Olr267 LOC500460 Olr192 Olr262 Olr1064 Olr896 Olr263 LOC100910049 Olr698 Olr799 LOC103693566 Olr922 Olr684 Olr1186 LOC100910120 Olr536 Olr1185 Olr143 Olr535 Olr140 Olr142 Olr148 LOC100910648 Olr1016 Olr149 Olr951 Gpr25 LOC100910224 Olr666 Olr1179 Olr522 Olr130 Olr527 Olr526 LOC100910637 Olr132 LOC100910010 Olr529 Olr528 Olr139 Olr137 Olr686 Olr1877 LOC100910559 Olr186 Olr189 Olr1081 Olr1147 Olr188 Olr584 Olr1082 Olr281 Olr382 Olr384 Olr1086 Olr1087 Olr587 Olr581 Olr282 Olr776 Olr582 Olr777 Olr583 Olr283 Olr962 Gpr15 Olr964 Olr285 Olr286 Olr1135 Olr1132 Olr172 LOC100910051 Olr1130 Olr170 Olr198 Olr588 Olr199 Olr1155 Olr597 Olr1057 Olr196 LOC100911805 Grk6 Olr252 Olr1052 Olr598 Olr695 Olr251 Olr250 Olr697 LOC100910999 Olr590 Grk5 LOC100910445 Olr1143 Olr180 Olr690 Olr1144 Olr783 Olr379 Olr1142 LOC100910162 Olr782 Gpr176 LOC100911839 Olr184 Olr845 LOC100910274 Olr847 Olr848 Olr1391 Gpihbp1 Olr852 Olr1496 LOC686792 LOC100912204 Olr1096 LOC100365798 RGD1562066 Olr844 Olr841 Olr744 Olr745 LOC100909686 Olr878 LOC100910597 Olr1376 Penk Olr850 Olr851 LOC100909578 LOC100909683 LOC100910294 Kng1 LOC687097 LOC100909884 LOC100909885 Olr1374 Olr1372 Olr1373 Olr1370 Kng2 Olr1071 Olr569 Olr174 Olr175 Olr774 Olr176 Htr4 Olr1274 Olr1076 LOC100910876 Olr575 Olr1075 Olr373 Olr1275 Olr1070 Olr1137 Htr7 Olr375 Olr377 Olr378 Olr372 Olr1079 Olr374 Olr1073 Olr854 Olr853 Olr279 LOC100911035 Olr765 Olr278 Olr376 Htr6 LOC100910256 Npff Npffr2 Olr834 Olr641 RGD1560028 LOC100909438 Psap Hcrt LOC100909796 Npffr1 Gpr83 Qrfp LOC690821 LOC100912217 LOC100909783 Olr601 Olr602 Olr604 Olr709 Olr609 Olr607 Olr608 LOC687088 Olfr873 Olr806 LOC686677 Olr702 Olr808 Olr705 Olr704 Olr807 Olr519 Oxgr1 Olr614 Olr718 Olr811 Ccr1 Olr514 Ccr1l1 Olr515 Ptgdr2 Olr611 Sucnr1 Olr610 Olr819 Olr716 Olr713 Olr816 Olr717 Olr714 Olr813 Olr812 Olr1382 Olr1381 Olr1384 Olr1383 Olr711 LOC100912327 Olr818 Olr712 Olr724 Olr1380 Reep6 LOC684683 Olr720 Olr722 LOC686660 Olr1385 Hcrtr1 Olr1378 Qrfpr Reep1 Cxcr2 Reep5 Hcrtr2 Olr729 Reep4 Reep3 Reep2 Olr725 Ptafr Gpr31 Cxcl2 Rgr Cxcl1 Gpr18 Gpr55 Gpsm3 Htr5a Gpsm2 Cxcl3 Gpsm1 Cnr2 Ccl4 Opn3 Cnr1 Htr1d Htr1f Htr1a Htr1b Hrh4 Ptger3 Gpr183 Mtnr1a Opn5 Pcp2 Hcar1 Hcar2 LOC687065 Drd5 Drd1 LOC684539 Drd4 Drd2 Olr820 Olr821 Olr823 Fpr1 Mgll Abhd12 Daglb Abhd6 Dagla C3ar1 Prkcd Kras Pik3r1 Pik3r2 Adra2a Gnai2 Adra2c Rbp4 C3 Lrp10 Rbp2 Ppbp Tex12 Rbp1 Lrp8 Apom Lrp12 Rhoa Lpl Bco1 Rdh11 Lrat Hras Nras Bco2 Sos1 Gnai1 Grb2 Olr1442 Olr1443 Olr1548 Olr80 Olr1440 Olr1547 Ppp1ca Pde4a Egfr Hbegf Pde4d Pde4c Ppp1r1b Ghrl Cdk5 Olr1436 Ptgir Olr1569 Olr1567 Olr1421 Olr1568 Olr1565 Olr1566 Olr1538 LOC100912374 Olr1539 Olr1437 Olr1439 Olr1433 Olr1434 Olr1435 LOC103690304 Olr83 LOC100912370 Olr1533 Olr1432 Olr1535 Olr1537 Olr1536 Olr81 Olr1449 Olr1542 Olr1541 Olr1540 Olr1445 LOC103693022 LOC100912463 Pnlip Clps Abca4 Prkca Oprl1 Tas2r144 Ccl21 Grm3 Casr Prokr2 Mc3r Grm1 Ccr5 Grm6 Gal Tas2r113 Ccr4 Grm2 Ccr3 Grm8 Gpr37 Ccl27 Cckar Tas2r114 Gper1 Tas2r110 Ccl20 Uts2r Prokr1 Ccl25 NMS Gprc6a Xcr1 Tas2r124 Cxcl16 Tas2r125 Pdyn Tas2r126 Tas2r121 Ccr10 Tas2r103 Gpr37l1 Tas2r104 Tas2r123 Ccl19 Ccr7 Tas2r116 Ccr8 Tas2r140 Cxcr3 Tas2r120 Tas2r102 Cxcl10 Ccr9 Tas2r145 Cxcl11 Tas2r119 Tas2r118 Tas2r117 Pde1b Sstr5 Brs3 Tas2r107 Tas2r108 Npbwr1 Tas2r105 Pyy Pnoc Tas2r106 Ccl5 Tas2r129 Npy2r Tas2r109 Mc4r Prkcq Tas2r136 Prok2 Tas2r137 Tas1r1 Oprm1 Prok1 Tas2r135 Mchr1 Sstr1 Tas2r13 Aplnr Tas2r130 Tas1r3 Sstr4 Tas2r139 Sstr2 Cck Npy1r Apln Tacr3 Apob Tacr2 Bdkrb1 Apoc2 Apoe Bdkrb2 Rln3 Apoa2 Npb Ppy Trh Ccl1 Npw Mc2r Npy Gng10 Nps Arhgef6 Arhgef5 Pde3a Arhgef39 Arhgef7 Arhgef37 Arhgef38 Arhgef33 Prex1 Adra1a Tbxa2r Itsn1 Arhgef2 LOC102556447 Arhgef4 Arhgef3 Plekhg5 Sstr3 Arhgef19 Arhgef18 Plekhg2 Kalrn Adra1d Plxnb1 LOC100912512 Gna12 Vav2 Gna13 Pde2a Vav1 Arhgef11 Cyct Akap13 Arhgef16 Pde10a Arhgef15 Pde11a Gphb5 Net1 Gnrhr Ect2 Gpha2 Arhgef26 Fgd2 Gnrh1 Mcf2l Tiam1 Fshr Tiam2 Vav3 Tshr Fgd3 Sos2 Ngef Cxcr5 Uts2b Npy5r Nmur2 Cxcr6 Oprd1 Trpc3 Trpc7 Lhcgr LOC100909513 Trpc6 LOC100360745 Olr1600 Olr1605 Olr1405 Olr1601 Olr1407 Olr1404 Olr1406 LOC100910837 Olr1368 Olr1369 Olr226 LOC100911348 Olr229 Olr227 Olr1602 LOC684170 LOC103692138 Olr1504 Lhb Olr233 Olr428 Olr232 Olr427 Olr1505 Olr234 LOC100911377 Olr1400 LOC100911376 Olr231 Ptgdr Olr425 Olr1501 Olr230 Olr208 Olr1202 Awat2 Adcy8 Olr244 LOC103693685 Adcy9 Olr1519 Adcy5 Olr203 Adcy4 Olr411 Adcy7 Olr209 Adcy6 Prkar1b Olr1007 Prkar1a Olr1006 LOC100911223 Ttr Olr237 Olr434 Olr1306 Olr442 Olr441 Olr113 Olr210 Olr1520 Olr114 Olr1523 Olr218 Olr1522 Olr1521 F2rl3 Olr206 F2r Olr1118 Olr204 F2 Olr205 RGD1564865 LOC100911398 Ptger2 Olr1115 Cga F2rl2 Olr1117 Hebp1 Uts2 Pde7a Pik3r5 Fpr-rs6 Ntsr2 Olr1734 Olr1340 Trhr Olr485 Nmu Fpr-rs3 Pf4 Olr486 Olr16 Mc5r Fpr2 Ntsr1 Olr1735 Fpr3 Pik3r3 LOC100911043 Pmch Anxa1 Pik3r6 Olr1737 Rxfp1 Olr14 Rxfp2 Olr1736 Fpr-rs4 Insl3 Olr488 Tac3 Olr484 Pde7b Kiss1 Olr1730 Rxfp3 LOC100912515 Tac1 Edn2 Olr1627 Olr491 Ednra Ednrb Olr1626 Edn3 Olr490 Grpr Olr1621 Cx3cr1 LOC100912408 Edn1 Olr1625 F2rl1 Olr1624 Olr200 Sst Olr339 Olr1345 Ackr3 Olr338 Nmb Olr1343 Xcl1 Cxcl9 Olr202 Olr1344 Cxcl6 Olr1341 Cx3cl1 Olr1356 Taar9 LOC100912605 LOC100911849 Hrh2 Fshb LOC100910199 Taar6 Agt Olr346 Taar5 Taar2 Olr1214 Olr450 Olr499 Olr496 LOC100912505 Olr493 Olr1606 Akt3 Olr1607 Olr1749 Agtr2 Olr1608 Olr1362 Galr1 Olr459 Nts Olr458 Olr1361 Oprk1 Olr1366 Olr1364 Olr360 Olr462 Olr1611 Olr1610 Olr1358 Olr1612 Olr20 Olr24 Olr23 Olr1456 LOC100912431 Olr1597 Olr1593 Olr1592 Olr1450 Olr1452 Olr1598 Olr1454 LOC100909966 LOC100365887 LOC100912159 Olr1654 LOC103693822 Olr30 Olr32 Pla2g4a Olr34 Olr331 Olr332 Olr1643 Olr334 Olr330 Olr1642 Olr1644 Olr1645 Olr473 Olr470 Olr1744 Olr1641 Olr1743 Olr1746 Olr472 Olr1640 Pde8b Olr477 Olr475 Pde8a LOC100911479 Olr1235 Olr1738 LOC103690286 Olr1231 Olr329 Or7e24 LOC103690280 Olr326 Olr325 Olr1339 Olr1639 Olr13 Olr12 Olr1637 Olr1638 Olr340 Olr341 LOC102555599 Olr1635 Gabbr1 Olr1630 Olr1631 Gabbr2 Olr1632 Olr1633 Olr1423 Olr1560 Olr63 LOC100912684 Olr1424 Olr1564 Olr1425 Olr1422 Olr1558 Olr1559 LOC684179 Olr1555 Ptgdrl Olr67 Olr68 Olr69 Olr1416 Cxcl12 Olr70 Olr1418 Olr1417 Olr1551 Adcy3 Prkar2b Olr1557 Prkar2a Olr1553 LOC686967 Olr77 LOC100909611 Olr1693 Rtp4 Olr74 Cxcr4 RGD1562400 Olr78 Olr75 Olr1583 Olr1589 Olr1488 LOC100912420 Olr1582 LOC100909993 Rtp3 Rtp2 Olr1475 Olr1470 LOC687110 Olr1576 Olr49 Olr46 Olr1588 Olr48 Arrb1 Olr1467 Olr1468 Olr1469 Olr50 Arrb2 Olr51 Olr59 Olr1671 Olr1471 Olr1667 Olr29 LOC100909831 Adrbk1 Olr27 Olr25 Cyp4v3 Olr1462 LOC100912540 LOC100911586 Rock2 Stra6 Rdh10 Rdh16 LOC100365958 LOC100362350 Akr1c12l1 Akr1c19 Akr1c13 Akr1c14 Akr1c12 Ccr6 Pomc Apoa1 Oxtr Oxt Rpe65 LOC100909648 Avpr1b Dhrs9 Pik3cg Avpr1a Myo7a Sdr9c7 Hsd17b6 Gpc6 Gpc4 Gpc2 Gpc1 Opn1sw Dhrs3 Rlbp1 Akr1b7 Akr1b8 Opn1mw Ghrh Ramp3 Vipr2 Sct Gip Gipr Akr1c2 Pth1r Iapp Crhr2 Akr1c3 Gcgr Crhr1 Glp2r Pth2 Ramp2 Ghrhr Akr1c1 Agrn Pdpk1 Sdc2 Sdc3 Sdc4 Adra2b Adrb3 Pth Sctr Adm Calcb Vip Calca Ramp1 Htr2c Htr2a Adcyap1r1 Dgkk Adcyap1 Dgki Pth2r Adm2 Htr2b Crh Lpar5 S1pr1 S1pr5 S1pr4 S1pr3 Lpar1 Lpar3 Lpar2 S1pr2 Ccl9 Ccl6 Dgkg Gpr4 Dgkd Dgke Dgka Dgkb Gpr132 Gnb3 Gpr143 Gnb5 Rgs3 Gnb2 Opn4 Rgs19 Gnb1 Rgs2 Gng13 Rgs18 Gng12 Hrh1 Gng11 Prkaca Chrm1 Prkacb Chrm5 Ghsr Itpr1 Arhgef25 Dgkz LOC100909523 Itpr3 LOC100912034 Dgkq Gnb4 Dgkh Cysltr2 Glp1r Camk4 Gcg Cysltr1 Gng4 Gpr65 Gngt2 Gpr68 Ptgfr Gng5 Gngt1 Prkch Ptger1 Gng8 Gng3 Chrm3 Agtr1b Agtr1a Chrm2 Ltb4r Ffar2 Ffar3 Ltb4r2 Avp Pde3b Akt2 P2ry6 Lpar6 P2ry4 P2ry1 Gpr17 Lpar4 P2ry12 P2ry2 P2ry10 P2ry13 Cckbr Gast Adrb2 Tacr1 PHOSPHATE BOND HYDROLYSIS BY NTPDASE PROTEINS%REACTOME DATABASE ID RELEASE 66%10146210 Phosphate bond hydrolysis by NTPDase proteins Entpd7 Entpd5 Entpd8 Entpd2 Entpd6 Entpd3 Entpd4 Entpd1 ANTAGONISM OF ACTIVIN BY FOLLISTATIN%REACTOME%R-RNO-2473224.1 Antagonism of Activin by Follistatin Fstl3 Fst Inhba PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR%REACTOME%R-RNO-392851.1 Prostacyclin signalling through prostacyclin receptor Ptgir Gnb3 Gnb5 Gnb2 Gnb1 Gng13 Gng12 Gng11 LOC100912034 Gnb4 Gng4 Gngt2 Gng5 Gngt1 Gng10 Gng8 Gng3 CHOLINE CATABOLISM%REACTOME%R-RNO-6798163.1 Choline catabolism Aldh7a1 Sardh Dmgdh Chdh MULTIFUNCTIONAL ANION EXCHANGERS%REACTOME DATABASE ID RELEASE 66%10145626 Multifunctional anion exchangers Slc26a2 Slc26a1 Slc26a7 Slc26a9 Slc26a6 Slc26a3 TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 66%10144823 tRNA Aminoacylation Sar1a Ppa2 OLFACTORY SIGNALING PATHWAY%REACTOME%R-RNO-381753.1 Olfactory Signaling Pathway Olr1442 Olr1443 Olr1548 Olr80 Olr1440 Olr1547 Olr1436 Olr1569 Olr1567 Olr1421 Olr1568 Olr1565 Olr1566 Olr1538 LOC100912374 Olr1539 Olr1437 Olr1439 Olr1433 Olr1434 Olr1435 LOC103690304 Olr83 LOC100912370 Olr1533 Olr1432 Olr1535 Olr1537 Olr1536 Olr81 Olr1449 Olr1542 Olr1541 Olr1540 Olr1445 LOC103693022 LOC100912463 Olr1600 Olr1605 Olr1405 Olr1601 Olr1407 Olr1404 Olr1406 LOC100910837 Olr1368 Olr1369 Olr226 LOC100911348 Olr229 Olr227 Olr1602 LOC684170 LOC103692138 Olr1504 Olr233 Olr428 Olr232 Olr427 Olr1505 Olr234 LOC100911377 Olr1400 LOC100911376 Olr231 Olr425 Olr1501 Olr230 Olr208 Olr1202 Olr244 LOC103693685 Olr1519 Olr203 Olr411 Olr209 Olr1007 Olr1006 LOC100911223 Olr237 Olr434 Olr1306 Olr442 Olr441 Olr113 Olr210 Olr1520 Olr114 Olr1523 Olr218 Olr1522 Olr1521 Olr206 Olr1118 Olr204 Olr205 LOC100911398 Olr1115 Olr1117 Olr1734 Olr1340 Olr485 Olr486 Olr16 Olr1735 LOC100911043 Olr1737 Gnal Olr14 Olr1736 Olr488 Olr484 Olr1730 LOC100912515 Olr1627 Olr491 Olr1626 Olr490 Olr1621 LOC100912408 Olr1625 Olr1624 Olr200 Olr339 Olr1345 Olr338 Olr1343 Olr202 Olr1344 Olr1341 Olr1356 LOC100912605 LOC100911849 LOC100910199 Olr346 Olr1214 Olr450 Olr499 Olr496 LOC100912505 Olr493 Olr1606 Olr1607 Olr1749 Olr1608 Olr1362 Olr459 Olr458 Olr1361 Olr1366 Olr1364 Olr360 Olr462 Olr1611 Olr1610 Olr1358 Olr1612 Olr20 Olr24 Olr23 Olr1456 LOC100912431 Olr1597 Olr1593 Olr1592 Olr1450 Olr1452 Olr1598 Olr1454 LOC100909966 LOC100365887 LOC100912159 Olr1654 LOC103693822 Olr30 Olr32 Olr34 Olr331 Olr332 Olr1643 Olr334 Olr330 Olr1642 Olr1644 Olr1645 Olr473 Olr470 Olr1744 Olr1641 Olr1743 Olr1746 Olr472 Olr1640 Olr477 Olr475 LOC100911479 Olr1235 Olr1738 LOC103690286 Olr1231 Olr329 Or7e24 LOC103690280 Olr326 Olr325 Olr1339 Olr1639 Olr13 Olr12 Olr1637 Olr1638 Olr340 Olr341 LOC102555599 Olr1635 Olr1630 Olr1631 Olr1632 Olr1633 Olr1423 Olr1560 Olr63 LOC100912684 Olr1424 Olr1564 Olr1425 Olr1422 Olr1558 Olr1559 LOC684179 Olr1555 Olr67 Olr68 Olr69 Olr1416 Olr70 Olr1418 Olr1417 Olr1551 Olr1557 Olr1553 LOC686967 Olr77 LOC100909611 Olr1693 Rtp4 Olr74 RGD1562400 Olr78 Olr75 Olr1583 Olr1589 Olr1488 LOC100912420 Olr1582 LOC100909993 Rtp3 Rtp2 Olr1475 Olr1470 LOC687110 Olr1576 Olr49 Olr46 Olr1588 Olr48 Olr1467 Olr1468 Olr1469 Olr50 Olr51 Olr59 Olr1671 Olr1471 Olr1667 Olr29 LOC100909831 Olr27 Olr25 Olr1462 LOC100912540 LOC100911586 Olr663 Olr660 Olr561 Olr1024 Olr560 LOC100910009 Olr158 Olr557 LOC100910335 Olr164 Olr659 Olr160 Olr657 Olr662 Olr664 Olr1868 Olr1199 Olr653 LOC100910402 Olr651 Olr650 Olr294 LOC100911909 Olr544 Olr1197 Olr1196 Olr1195 Olr1194 Olr1198 LOC100910409 Olr1128 LOC100911893 LOC100910928 Olr323 Olr119 Olr1126 LOC100912097 Olr1125 Olr420 Olr217 Olr1121 Olr1122 Olr1129 Olr322 Olr214 Olr215 Olr414 Olr1512 Olr1513 Olr416 Olr556 Olr1511 Olr413 Olr1517 Olr319 Olr120 Olr321 Olr1514 LOC100911380 Olr417 Olr418 LOC100910041 Olr259 Olr1163 Olr1166 LOC684208 Olr127 Olr530 Olr126 Olr931 Olr674 Olr129 Olr532 Olr1174 Olr670 Olr675 Olr892 Olr247 Olr1156 Olr190 Olr194 Olr267 LOC500460 Olr192 Olr262 Olr1064 Olr896 Olr263 LOC100910049 Olr698 Olr799 LOC103693566 Olr922 Olr684 Olr1186 LOC100910120 Olr536 Olr1185 Olr143 Olr535 Olr140 Olr142 Olr148 LOC100910648 Olr1016 Olr149 Olr951 LOC100910224 Olr666 Olr1179 Olr522 Olr130 Olr527 Olr526 LOC100910637 Olr132 LOC100910010 Olr529 Olr528 Olr139 Olr137 Olr686 Olr1877 LOC100910559 Olr186 Olr189 Olr1081 Olr1147 Olr188 Olr584 Olr1082 Olr281 Olr382 Olr384 Olr1086 Olr1087 Olr587 Olr581 Olr282 Olr776 Olr582 Olr777 Olr583 Olr283 Olr962 Olr964 Olr285 Olr286 Olr1135 Olr1132 Olr172 LOC100910051 Olr1130 Olr170 Olr198 Olr588 Olr199 Olr1155 Olr597 Olr1057 Olr196 LOC100911805 Olr252 Olr1052 Olr598 Olr695 Olr251 Olr250 Olr697 LOC100910999 Olr590 LOC100910445 Olr1143 Olr180 Olr690 Olr1144 Olr783 Olr379 Olr1142 LOC100910162 Olr782 LOC100911839 Olr184 Olr845 LOC100910274 Olr847 Olr848 Olr1391 Olr852 Olr1496 LOC686792 LOC100912204 Olr1096 LOC100365798 RGD1562066 Olr844 Olr841 Olr744 Olr745 LOC100909686 Olr878 LOC100910597 Olr1376 Olr850 Olr851 LOC100909578 LOC100909683 LOC100910294 LOC687097 LOC100909884 LOC100909885 Olr1374 Olr1372 Olr1373 Olr1370 Olr1071 Olr569 Olr174 Olr175 Olr774 Olr176 Olr1274 Olr1076 LOC100910876 Olr575 Olr1075 Olr373 Olr1275 Olr1070 Olr1137 Olr375 Olr377 Olr378 Olr372 Olr1079 Olr374 Olr1073 Olr854 Olr853 Olr279 LOC100911035 Olr765 Olr278 Olr376 LOC100910256 Olr834 Olr641 LOC100909438 LOC100909796 LOC690821 LOC100912217 Olr601 Olr602 Olr604 Olr709 Olr609 Olr607 Olr608 LOC687088 Olfr873 Olr806 LOC686677 Olr702 Olr808 Olr705 Olr704 Olr807 Olr519 Olr614 Olr718 Olr811 Olr514 Olr515 Olr611 Olr610 Olr819 Olr716 Olr713 Olr816 Olr717 Olr714 Olr813 Olr812 Olr1382 Olr1381 Olr1384 Olr1383 Olr711 LOC100912327 Olr818 Olr712 Olr724 Olr1380 Reep6 LOC684683 Olr720 Olr722 LOC686660 Olr1385 Olr1378 Reep1 Reep5 Olr729 Reep4 Reep3 Reep2 Olr725 Gnb1 LOC687065 LOC684539 Olr820 Gngt1 Olr821 Olr823 VLDLR INTERNALISATION AND DEGRADATION%REACTOME%R-RNO-8866427.1 VLDLR internalisation and degradation Ap2a2 Pcsk9 Clta Nr1h3 Nr1h2 Vldlr Ap2s1 Mylip Ap2a1 Ap2m1 Cltc BETA OXIDATION OF HEXANOYL-COA TO BUTANOYL-COA%REACTOME%R-RNO-77350.1 Beta oxidation of hexanoyl-CoA to butanoyl-CoA LOC100911186 Echs1 Hadh Acads Hadha Hadhb FANCONI ANEMIA PATHWAY%REACTOME%R-RNO-6783310.1 Fanconi Anemia Pathway Eme2 Wdr48 Eme1 Rpa1 Rpa2 Ercc1 Atrip Rpa3 RGD1564719 RGD1306926 Fance Fanca Fancf Ube2t Fancc Fancb Fancl Fanci Atr Usp1 Slx4 Poln Mus81 Dclre1a Slx1b Fan1 REGULATION OF TP53 ACTIVITY THROUGH ASSOCIATION WITH CO-FACTORS%REACTOME%R-RNO-6804759.1 Regulation of TP53 Activity through Association with Co-factors Tp63 Tp53bp2 Pou4f2 LOC100910954 Banp Akt1 Akt3 Zfp385a Ppp1r13b Ppp1r13l Tp73 Phf20 Akt2 CLEC7A (DECTIN-1) INDUCES NFAT ACTIVATION%REACTOME%R-RNO-5607763.1 CLEC7A (Dectin-1) induces NFAT activation RGD1560225 Ppp3ca Nfatc2 Ppp3r1 Nfatc3 GP1B-IX-V ACTIVATION SIGNALLING%REACTOME DATABASE ID RELEASE 66%10145640 GP1b-IX-V activation signalling Flna Gp1ba Src Gp9 Gp5 Gp1bb LOC100911551 Pik3r1 Raf1 Vwf Ywhaz CATION-COUPLED CHLORIDE COTRANSPORTERS%REACTOME DATABASE ID RELEASE 66%10145620 Cation-coupled Chloride cotransporters Slc12a4 Slc12a2 Slc12a1 Slc12a6 Slc12a7 Slc12a5 FGFRL1 MODULATION OF FGFR1 SIGNALING%REACTOME%R-RNO-5658623.1 FGFRL1 modulation of FGFR1 signaling Fgf23 Fgf22 Fgf4 Spred1 Spred2 Fgf3 Fgf17 Fgfrl1 Fgf10 Fgf5 Fgf2 Fgf8 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS%REACTOME%R-RNO-111465.1 Apoptotic cleavage of cellular proteins Prkcd Bmx Rock1 Apc Dsg3 Birc2 Dsg2 Sptan1 Lmna Casp3 Mapt Casp6 Stk26 Stk24 Add1 Acin1 Gas2 Ocln Tjp2 Bcap31 Dsp Cdh1 Casp8 Dsg1 Clspn Prkcq Plec Gsn Lmnb1 Pkp1 Vim Dbnl Fnta Ptk2 Satb1 MICRORNA (MIRNA) BIOGENESIS%REACTOME%R-RNO-203927.1 MicroRNA (miRNA) biogenesis Prkra Ago3 Dicer1 Ago4 Ago2 Tarbp2 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES%REACTOME%R-RNO-1834941.1 STING mediated induction of host immune responses Nlrp4 Dtx4 Tbk1 Ddx41 Nlrp4a Irf3 Stat6 Tmem173 MEIOTIC RECOMBINATION%REACTOME%R-RNO-912446.1 Meiotic recombination Prdm9 RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF KERATINOCYTES%REACTOME DATABASE ID RELEASE 66%10146265 RUNX1 regulates transcription of genes involved in differentiation of keratinocytes MGC114246 Cts8l1 LOC100364523 Testin RGD1308751 Ctsl Cts8 Cts7 Ctsm Ctsj RGD1564657 RGD1564827 Ctsk Ctsq Serpinb13 Ctsr MITOCHONDRIAL PROTEIN IMPORT%REACTOME DATABASE ID RELEASE 66%10146287 Mitochondrial protein import Pitrm1 Hscb Ldhd Otc Atp5b Ndufb8 Coq2 ENZYMATIC DEGRADATION OF DOPAMINE BY MONOAMINE OXIDASE%REACTOME DATABASE ID RELEASE 66%10145518 Enzymatic degradation of Dopamine by monoamine oxidase Maoa Comt G ALPHA (Z) SIGNALLING EVENTS%REACTOME%R-RNO-418597.1 G alpha (z) signalling events Adcy3 Gnaz Adcy8 Adcy9 Adcy5 Adra2a Adcy4 Adcy7 Adcy6 Adra2c Gnb3 Adra2b Gnb5 Gnb2 Gnb1 Gng13 Gng12 Gng11 LOC100912034 Gnb4 Gng4 Gngt2 Gng5 Gngt1 Gng10 Gng8 Gng3 SURFACTANT METABOLISM%REACTOME DATABASE ID RELEASE 66%10145605 Surfactant metabolism Adgrf5 Napsa Sftpa1 Csf2ra Csf2rb Adra2a Lmcd1 Adra2c Abca3 Slc34a1 Ccdc59 Adora2a Zdhhc2 Adora2b Sftpb Ckap4 Ttf1 P2ry2 AUTODEGRADATION OF CDH1 BY CDH1:APC C%REACTOME DATABASE ID RELEASE 66%10145213 Autodegradation of Cdh1 by Cdh1:APC C Psmc6 Psmb10 Psmb8 Psmb9 Psmb4 Psmb5 Psmf1 Psmb6 Psmd4 Psmb2 Psmd5 Psmd8 Psmd9 Psmb3 Psmd11 Psmd12 Anapc11 Anapc15 Psmd13 Anapc10 Psmd14 Fzr1 Psmc3 G6pc Ube2d1 Psmb7 Psmb1 Anapc7 Cdc26 Cdc27 Psma5 Cdc23 Ube2c Anapc16 Cdc16 Anapc4 Psma2 Anapc2 Anapc1 Psmc5 Psmd2 Psma1 Psma4 Psmc1 Psma3 Psmc4 Psmc2 Psma6 Psme1 Psmd1 Psme2 Psmd7 Psmd3 Psmd6 GLYCOPROTEIN HORMONES%REACTOME DATABASE ID RELEASE 66%10145514 Glycoprotein hormones Lhb Fshb Inha Inhbc Tshb Cga Inhba RRNA PROCESSING IN THE NUCLEUS AND CYTOSOL%REACTOME DATABASE ID RELEASE 66%10146162 rRNA processing in the nucleus and cytosol Rps20 Rps27l LOC100360573 Rps4x LOC100359951 LOC100359593 LOC100359503 LOC100362640 Rps3 Rps15a Rps2 Rps13 Rps12 LOC100911372 LOC100361854 LOC684988 LOC103689992 Rps5 Rps7 Rps6 LOC100362830 LOC100363012 LOC100362149 Exosc3 Exosc9 LOC100359574 Exosc2 Exosc1 Exosc4 Exosc7 Exosc5 Dcaf13 Tbl3 Tsr1 Emg1 Wdr75 Wdr18 Wdr43 Wdr46 Nhp2l1 C1d Nob1 Fcf1 Wdr12 Senp3 Wdr36 Ebna1bp2 Rpp25 Riok3 Riok1 Utp14a Bysl NEWGENE_1564769 Rpp21 Pdcd11 Rpp40 Skiv2l2 Heatr1 Riok2 Rpp38 Rrp36 Rpp30 Bop1 Utp20 Dhx37 Utp18 Gnl3 Utp15 Utp11l Pno1 Pwp2 Wbscr22 Mphosph6 Imp4 Imp3 Nop56 Tex10 Utp6 Rcl1 Nol6 Utp3 Ncl Nop14 Xrn2 Rrp9 Rrp7a Pes1 Exosc10 Krr1 Nol9 Mphosph10 LOC100910568 Rpp14 Cirh1a Diexf Nop58 Ddx52 Rps16 Ltv1 Wdr3 Noc4l Ddx49 Ddx47 Las1l Fbl Rps18 LOC100360679 Rps15 Ddx21 Rps3a Csnk1d Csnk1e INITIATION OF NUCLEAR ENVELOPE REFORMATION%REACTOME DATABASE ID RELEASE 66%10145989 Initiation of Nuclear Envelope Reformation Vrk2 Vrk1 METABOLISM OF STEROIDS%REACTOME DATABASE ID RELEASE 66%10145088 Metabolism of steroids Nr1h4 Ppapdc2 Mbtps1 Mbtps2 Sc5d Hsd17b3 Lhb Acot8 Hsd17b1 Nsdhl Hsd17b2 Osbpl3 Hsd17b4 Osbpl6 Osbpl9 Stard6 Osbpl7 Cyp19a1 Stard3 Fdx1l RGD1562948 Gc Msmo1 Stard4 Stard5 Acat2 Akr1c12l1 LOC100911154 Baat Cyp46a1 Mvd Akr1c19 Hsd3b Akr1c13 Akr1c14 RGD1564865 Akr1c12 Cga Amacr Akr1d1 Cyp39a1 Pomc Vdr Scap Cyp51 Fdx1 Cubn Slc21a4 Hsd3b1 Bzrap1 Hsd3b2 Abcb11 Hsd3b7 Stard3nl Acox2 Ch25h Srd5a3 RGD1564347 Slc27a2 Tspo Cyp24a1 Srd5a1 Srd5a2 Pmvk Srebf1 Dhcr24 Srebf2 Slco1a1 Kpnb1 Arv1 Sqle Ptgis Slco1a4 Slco1a2 Lgmn RGD1306195 Rxra Slco1b2 Akr1b7 Akr1b8 Fabp6 Star Cyp7b1 Fdft1 Hmgcs1 Akr1c2 Akr1c3 Cyp7a1 Tm7sf2 Cyp21a1 Fdxr Cyp2r1 Ncoa1 Akr1c1 Osbp Ggps1 Slc27a5 Cyp11b2 Cyp27b1 Slco1a6 Ncoa2 Dhcr7 Akr1b1 Cyp8b1 Hsd17b14 Slc10a1 Hmgcr Ebp Hsd11b2 Slc10a2 Hsd17b12 Hsd17b11 REGULATION OF GENE EXPRESSION IN BETA CELLS%REACTOME%R-RNO-210745.1 Regulation of gene expression in beta cells Akt3 Foxo1 Akt1 Akt2 ACTIVATION OF BH3-ONLY PROTEINS%REACTOME DATABASE ID RELEASE 66%10145046 Activation of BH3-only proteins Mapk8 Dynll2 Ywhah Bcl2l11 Ywhag Sfn Ywhaz Ppp3r1 Bcl2 Bid Ywhab Ywhaq Ywhae Bmf Pmaip1 Bad EXPRESSION AND PROCESSING OF NEUROTROPHINS%REACTOME%R-RNO-9036866.1 Expression and Processing of Neurotrophins Ngf Pcsk6 Pcsk5 Furin G2 PHASE%REACTOME DATABASE ID RELEASE 66%10145274 G2 Phase Cdk2 E2f1 E2f3 Ccna2 Ccna1 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION%REACTOME%R-RNO-109688.1 Cleavage of Growing Transcript in the Termination Region Rnps1 Thoc5 Thoc7 Thoc3 Snrpf Thoc2 Thoc1 Wdr33 Magohb Rbm8a Pcf11 Fip1l1 Thoc6 Nudt21 Zfp473 Snrpd3 Ddx39a Cstf2 Ddx39b Chtop U2af1l4 Cpsf7 Cpsf2 Cpsf3 Cpsf4 Cstf1 Cpsf1 Sarnp Slu7 Srsf3 Upf3b U2af2 Papola Srsf6 Srsf7 Srsf4 Lsm10 Lsm11 Srsf5 Srsf2 LOC679894 Srsf9 Dhx38 Clp1 Magoh Ncbp2 Srsf1 Poldip3 Ncbp1 Cstf2t Eif4a3 Fyttd1 Sympk Slbp LOC100910660 Srrm1 Cdc40 LOC361990 Snrpb CA2+ PATHWAY%REACTOME DATABASE ID RELEASE 66%10145578 Ca2+ pathway Plcb1 Pde6b Nlk Plcb3 Wnt5a Pde6a Camk2a Fzd3 Fzd2 Gnao1 Fzd4 Fzd6 Ppp3r1 Wnt11 Gnat2 Map3k7 Gnb3 Gnb5 Gnb2 Gnb1 Gng13 Gng12 Gng11 RGD1560225 Ppp3ca LOC100910771 LOC100912034 Gnb4 Lef1 Gng4 Gngt2 Gng5 Gngt1 Gng10 Gng8 Pde6g Gng3 VITAMIN E%REACTOME DATABASE ID RELEASE 66%10146249 Vitamin E Ttpa INTRACELLULAR SIGNALING BY SECOND MESSENGERS%REACTOME DATABASE ID RELEASE 66%10144994 Intracellular signaling by second messengers Ereg Nrg1 Trim27 Btc Usp7 LOC102552659 Mdm2 Erbb3 Erbb2 Nrg3 Egfr Hbegf Esr2 Nrg4 Csnk2a2 Nr4a1 Csnk2a1 Pml Fyn Il1rap Nrg2 Pik3ap1 Il1rl1 Akt1 Hdac1 Phlpp1 Ier3 Pdgfa Rps6kb2 Pdgfb Foxo1 Foxo3 Pik3cd Stub1 Irak4 Cdkn1a Cdkn1b Prkca Traf6 Il33 Pip5k1c Pde1b Pip5k1b Pip5k1a Cd19 LOC100909468 Hgf Rac2 Ppp2r5e G6pc Pdgfra Pdgfrb Frk Psmb7 Psmb1 Ppp2r5c Ppp2r5a Ppp2r5b Vav1 Foxo4 Psma5 Pdpk1 Psma2 Psmd2 Psmc2 Psmd1 Psmd7 Kit Kitlg Psmd3 Psmd6 Psmc6 Pten Psmb10 Psmb8 Psmb9 Psmb4 Psmb11 Psmb5 Psmf1 Psmb6 Rac1 Psmd4 Psmb2 Psmd5 Psmd8 Psmd9 Psmb3 Psma8 Psmd11 Psmd12 Psmd13 Psmd14 RragB Rictor Adcy8 Adcy9 Adcy5 Adcy4 Adcy7 Adcy6 Prkar1b Prkar1a Fgf2 Psmc3 Pip4k2b Pip4k2c Src Pik3r3 Akt1s1 Ppp2cb Ppp2ca Ppp2r1a Xiap Tnks Phc1 Phc2 Mtor Rheb Rptor Lamtor4 Chuk Lamtor5 Ppp2r1b Mlst8 Tsc2 Rraga Mapk1 Rragc Prkaca Prkacb Akt3 Rragd Slc38a9 Creb1 Camk4 Myd88 Cd80 Cd86 Otud3 Fgf23 Fgf22 Fgf4 Fgf1 Fgf3 Fgf6 Fgf5 Lamtor3 Fgf20 Gab1 Sall4 Scmh1 Cbx4 Cbx2 Cbx8 Fgf16 Lamtor2 Cbx6 Fgf17 Lamtor1 Bmi1 Irs2 Hdac2 Fgf10 Fgf9 Rnf2 Fgfr2 Mbd3 Fgf7 Usp13 Fgf8 Ring1 Chd3 Hdac1l Fgfr3 Chd4 Trib3 Phc3 Fgfr1 Prex2 Fgfr4 Esr1 Insr Ins1 Ins2 Mta3 Fgf19 Erbb4 Tnks2 Them4 Irs1 Mta1 Frs2 Mta2 Gatad2a LOC100910717 Maf1 Gatad2b Akt2 Prkcd Eed Pik3r1 Pik3r2 Rbbp7 Mecom Cd28 Icos Adcy3 Prkar2b Prkar2a Casp9 Csnk2b Mapkap1 Psmc5 Pik3cb Psma1 Psma4 Psmc1 Ptpn11 Psma3 Psmc4 Psma6 Psme1 Ezh2 Psme2 Adrbk1 Rhog Grb2 RECEPTOR MEDIATED MITOPHAGY%REACTOME DATABASE ID RELEASE 66%10146273 Receptor Mediated Mitophagy Csnk2a2 Csnk2b Ulk1 Src Atg12 Map1lc3a Csnk2a1 Pgam5 Fundc1 SOS-MEDIATED SIGNALLING%REACTOME%R-RNO-112412.1 SOS-mediated signalling Irs2 Irs1 Sos1 Grb2 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT%REACTOME%R-RNO-201681.1 TCF dependent signaling in response to WNT Psmc6 Psmb10 Psmb8 Psmb9 Psmb4 Psmb11 Psmb5 Psmf1 Psmb6 Psmd4 Rbx1 Psmb2 Psmd5 Psmd8 Csnk2a2 Psmd9 Leo1 Psmb3 Psma8 Psmd11 Csnk2a1 Psmd12 Psmd13 Psmd14 LOC100361515 Psmc3 Lrp5 Lrp6 Wnt3 Rnf43 Rspo1 Lgr4 Lgr6 Lgr5 Rspo4 Sox9 Wnt3a Rspo2 Usp8 Rspo3 Rbbp5 Wnt5a Akt1 Fzd1 Hdac1 Fzd2 Fzd4 Fzd6 Ywhaz Wnt1 Xiap Tnks Btrc Apc Dkk1 Kremen2 Sost Chd8 Hist1h2bo Hist1h2bcl1 Hist2h3c2 Hist1h2bk Pip5k1b H3f3b Smarca4 Hdac1l Xpo1 Tle3 Tnks2 Crebbp LOC100910717 Akt2 Peg12 LOC100910200 Cdc73 H2afx Frat2 Hist1h4b LOC684841 G6pc Hist1h2bh LOC100912290 Hist1h2ail1 Hist1h4m LOC102549173 LOC103690002 Tert LOC100910152 Men1 Psmb7 LOC100912338 Hist1h3c Psmb1 H2afb3 Hist1h3f Hist2h4 LOC684819 Hist1h3a H2afj Hist2h2aa3 Hist1h2bq Hist2h2aa2 Ash2l LOC100364835 LOC684762 Sox2 Hecw1 Csnk2b Dact1 Wnt8a Psma5 Sox7 Sox6 Sry Sox17 Ctnnbip1 Dvl1 Ryk Wnt8b Dkk2 Dkk4 Cby1 Psma2 Sox13 Psmc5 Pygo2 Psmd2 Psma1 Dvl2 Psma4 Dvl3 Psmc1 Psma3 Csnk1e Psmc4 Psma6 Psmc2 Psme1 Hist1h2bg Tcf7 Psme2 Lef1 Psmd1 Psmd7 Tcf7l1 LOC680097 LOC684797 Bcl9l Tle4 LOC100912418 Tle1 Hist1h2ba Tle2 Psmd3 Hist3h2bb Psmd6 Pygo1 OTHER INTERLEUKIN SIGNALING%REACTOME%R-RNO-449836.1 Other interleukin signaling Csf1 Stxbp2 Csf1r Ptprz1 Txlna Stx1a Csf3r Casp3 Vamp2 Stx3 Stx4 Il16 Cd4 Csf3 INTRA-GOLGI TRAFFIC%REACTOME DATABASE ID RELEASE 66%10146194 Intra-Golgi traffic Cux1 Stx5 Napg Ric1 Napb Napa Rab36 Rgp1 Man1c1 Nsf Alppl2 Stx16 Man1a1 Golim4 Cog4 Golga5 Cog6 Cog8 Cog3 Man2a1 Alpp Cog1 Alpi Cog2 Man2a2 Cog7 Snap29 Stx6 Rab30 Rab39a Cyth1 Cyth4 Rab33b Cyth3 Man1a2 Cyth2 Trip11 Ykt6 Gosr2 Gosr1 Vps45 GRB2 EVENTS IN ERBB2 SIGNALING%REACTOME DATABASE ID RELEASE 66%10145849 GRB2 events in ERBB2 signaling Ereg Nrg1 Kras Btc LOC102552659 Erbb2 Nrg3 Hbegf Nrg4 Erbb4 Hras Nras Sos1 Nrg2 Grb2 DAP12 INTERACTIONS%REACTOME%R-RNO-2172127.1 DAP12 interactions Kras Pik3r1 Pik3r2 Klrc2 Rac1 Cd300lb Siglec15 Trem2 Cd300e LOC100360575 Sirpa Tyrobp Vav2 Trem1 Fyn Vav3 Clec5a B2m Pik3cb Lat Plcg1 Hras Nras Sos1 LOC100909879 Lcp2 Shc1 Syk Grb2 ORGANIC ANION TRANSPORT%REACTOME%R-RNO-561048.1 Organic anion transport Slc22a7 Slc22a6 TRYPTOPHAN CATABOLISM%REACTOME%R-RNO-71240.1 Tryptophan catabolism Aadat Kmo Kynu Ccbl1 Ido1 Slc7a5 Slc36a4 Tdo2 SYNTHESIS OF LIPOXINS (LX)%REACTOME DATABASE ID RELEASE 66%10145463 Synthesis of Lipoxins (LX) Hpgd Alox5ap Alox12 Ltc4s Alox5 AXONAL GROWTH STIMULATION%REACTOME%R-RNO-209563.1 Axonal growth stimulation Ngf Rhoa Arhgdia Ngfr SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL%REACTOME%R-RNO-1855183.1 Synthesis of IP2, IP, and Ins in the cytosol Inpp1 Inpp5a Isyna1 Inpp5b Synj1 Impa1 Inpp4a Ocrl Impa2 Inpp5j Inpp4b RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 66%10144903 RNA Polymerase II Transcription Initiation And Promoter Clearance Gtf2h1 Gtf2h2 Gtf2e1 Gtf2e2 Mnat1 RGD1565904 Taf11 Polr2g Ercc3 Taf2 Polr2h Taf15 Polr2e Polr2f Polr2j Taf13 Taf9 Polr2k Taf12 Polr2d LOC100911822 Taf7 Polr2i Taf4b Polr2b Polr2c Taf3 Ercc2 Taf6 Polr2a Taf5 Gtf2f1 LOC100912534 Gtf2f2 Gtf2a1 Cdk7 Atp5c1 Taf10 Taf7l Gtf2b Ccnh Gtf2h3 Gtf2h5 Tbp Gtf2h4 Taf9b SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21%REACTOME DATABASE ID RELEASE 66%10145271 SCF(Skp2)-mediated degradation of p27 p21 Psmc6 Psmb10 Psmb8 Psmb9 Psmb4 Psmb5 Psmf1 Psmb6 Psmd4 Cul1 Psmb2 Psmd5 Ptk6 Psmd8 Psmd9 Psmb3 Psmd11 Psmd12 Ccna2 Ccne2 Ccna1 Psmd13 Psmd14 Ccne1 Cdk2 Cks1l Psmc3 Cks1b G6pc Cdk4 Psmb7 Psmb1 Ccnd1 Skp1 Psma5 Skp2 Cdkn1a Cdkn1b Psma2 Psmc5 Psmd2 Psma1 Psma4 Psmc1 Psma3 Psmc4 Psmc2 Psma6 Psme1 Psmd1 Psme2 Psmd7 Psmd3 Psmd6 GLYOXYLATE METABOLISM AND GLYCINE DEGRADATION%REACTOME%R-RNO-389661.1 Glyoxylate metabolism and glycine degradation Ndufab1 Ogdh LOC683884 Gcsh LOC100911156 Pdhb LOC100365902 Pdha2 Pdha1 Pdhx Pdha1l1 Got2 Lipt2 Lipt1 Agxt2 Bckdhb Amt Grhpr Hao1 Hoga1 Gnmt Tas1r2 Ddo Dhtkd1 LOC100911564 Dlat Aldh4a1 Dbt Gldc Dlst Agxt Iffo2 Lias Dld ERYTHROPOIETIN ACTIVATES RAS%REACTOME DATABASE ID RELEASE 66%10146321 Erythropoietin activates RAS Irs2 Lyn Epor Crkl Vav1 Rapgef1 Shc1 Grb2 Epo LOC100911248 MITOCHONDRIAL UNCOUPLING PROTEINS%REACTOME DATABASE ID RELEASE 66%10145136 Mitochondrial Uncoupling Proteins Ucp2 Ucp3 LOC100909612 Slc25a14 Ucp1 INTERACTION BETWEEN L1 AND ANKYRINS%REACTOME DATABASE ID RELEASE 66%10145576 Interaction between L1 and Ankyrins L1cam Ank1 Spta1 Sptbn1 Sptan1 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX%REACTOME%R-RNO-204174.1 Regulation of pyruvate dehydrogenase (PDH) complex Gstz1 Pdp1 Pdpr Rxra Dlat Pdhb Pdk3 Pdk4 Pdk1 Pdk2 LOC100365902 Pdha2 Pdha1 Pdhx Ppard Pdha1l1 Dld ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S%REACTOME%R-RNO-72662.1 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S LOC100912571 Eif3l Eif2s3 Eif3m Eif3j Eif4ebp1 Eif3k Rps20 Rps27l Eif3e Eif3f Eif3b Eif3a Eif3d Eif3c LOC100360573 Eif2s1 Eif2s2 Eif4g1 Rps4x LOC100359951 LOC100359593 LOC100359503 LOC100362640 Rps3 Rps15a Rps2 Rps13 Rps12 Pabpc2 Pabpc6 LOC100911372 LOC100361854 LOC684988 LOC103689992 Rps5 Rps7 Rps6 Eif3g Eif3h Eif4a2 LOC100362830 Eif1ax Eif4a1 LOC100363012 LOC680559 LOC100911110 LOC100362149 Rps16 LOC100911431 Pabpc1 Rps18 LOC100360679 Rps15 Eif4h Eif4b Rps3a SYNTHESIS OF DOLICHYL-PHOSPHATE%REACTOME DATABASE ID RELEASE 66%10145306 Synthesis of Dolichyl-phosphate Dolk Mvd Nus1 Dolpp1 Srd5a3 Dhdds KETONE BODY CATABOLISM%REACTOME%R-RNO-77108.1 Ketone body catabolism Acat1 Oxct1 REDUCTION OF CYTOSOLIC CA++ LEVELS%REACTOME%R-RNO-418359.1 Reduction of cytosolic Ca++ levels Atp2b4 Atp2a2 Sri Atp2b2 Atp2b1 Slc8a2 Slc8a3 Slc8a1 Atp2a3 TCR SIGNALING%REACTOME DATABASE ID RELEASE 66%10145376 TCR signaling Psmc6 Pten Psmb10 Psmb8 Psmb9 Psmb4 Psmb11 Psmb5 Psmf1 Psmb6 Traf6 Psmd4 Psmb2 Cul1 Psmd5 Fyb Psmd8 Psmd9 Psmb3 Nck1 Psma8 Psmd11 Cdc34 Psmd12 Cd4 Psmd13 Rela Psmd14 Map3k7 Ptprc Prkcq Psmc3 Pak2 Nfkbia Pak3 LOC100910771 Ube2n Pak1 Bcl10 G6pc Pik3r1 Pik3r2 Ptpn22 Ube2d1 Ptprj Psmb7 Inpp5d Psmb1 Cd3e RT1-Ba RT1-Bb Skp1 RT1-Da RT1-Db2 RT1-Db1 LOC688090 Was Nfkb1 Cd247 Cd101 Psma5 Csk Fbxw11 Chuk Btrc Pdpk1 Psma2 Psmc5 Pik3cb Cd3g Psma1 Psmd2 LOC100362142 Psma4 Psmc1 Cd3d Psma3 Psmc4 Psma6 Psmc2 Lat Tab2 Psme1 Plcg1 LOC100912618 Ube2v1 Psme2 Psmd1 Ikbkb Psmd7 Lcp2 Psmd3 Itk Psmd6 SUMOYLATION%REACTOME%R-RNO-2990846.1 SUMOylation Nr1h4 Nup43 Nup133 Trim27 Mdm2 Vhl Pias3 Aaas Pias1 Npap60 Stag1 Nup35 Nup37 Pias4 Pml Rad21 Pias2 Smc1a Stag2 Smc3 Sumo1 Sumo3 Pcna Brca1 Blm Mdc1 Zfp131 Pcgf2 Xpc Ube2i Hdac4 Uhrf2 Ranbp2 Foxl2 Satb2 Satb1 Birc5 Topors Thra Thrb Nsmce1 Ing2 Nsmce2 Mbd1 Nr1h3 Nr1h2 Top1 Safb Park7 Smc6 Tp53bp1 Smc5 Nr5a1 Rora Senp5 Nr1i2 Rad52 Mitf Herc2 Hdac1 Xrcc4 LOC100911274 Nup88 Rpa1 Hipk2 Nup85 Phc1 Phc2 Nfkb2 Tfap2c Sin3a Rae1 Nup93 Nup98 Nup107 Rxra Nup210 Ppara Nupl2 Rela Nupl1 Tdg Cdca8 Scmh1 Nr5a2 Cbx4 Cbx2 Cbx8 Bmi1 Hdac2 Rnf2 Rangap1 Ikbke Ring1 Hdac1l Phc3 Aurkb Esr1 Nfkbia Nup205 Ddx5 Mta1 Nrip1 Pgr Ncoa1 Hist1h4b Incenp Dnmt1 LOC100912290 Nup155 Nop58 Hist1h4m LOC690251 Dnmt3b Hist2h4 Sae1 Uba2 Nup153 Rwdd3 Parp1 Tpr Daxx Mkl1 Senp2 Nup54 Senp1 Pom121 LOC680097 Nup62 LOC100912418 CALMODULIN INDUCED EVENTS%REACTOME DATABASE ID RELEASE 66%10144991 Calmodulin induced events Prkcd Pde1b Adcy8 Adcy9 Adcy5 Adcy4 Adcy7 Adcy6 Prkar1b Prkar1a Prkaca Prkacb Adcy3 Prkar2b Prkca Prkar2a Camk4 Adrbk1 ACTIVATION OF PKB%REACTOME DATABASE ID RELEASE 66%10144955 Activation of PKB Them4 Trib3 Pdpk1 Akt2 MET ACTIVATES PTK2 SIGNALING%REACTOME DATABASE ID RELEASE 66%10146246 MET activates PTK2 signaling Hgf Lama4 Src Lamc1 Lamc2 Lamb1 Itga3 Ptk2 Lama1 Lamb2 Lamb3 OPIOID SIGNALLING%REACTOME%R-RNO-111885.1 Opioid Signalling Plcb1 Ppp1ca Pde4a Plcb3 Pde4d Pde4c Ppp1r1b Cdk5 Pla2g4a Pdyn Pde1b Adcy8 Adcy9 Adcy5 Adcy4 Adcy7 Adcy6 Prkar1b Prkar1a Oprm1 Plcb4 Gnat1 Gng10 Prkcd Gnai3 Pomc Gnal Gnat3 Ppp2cb Gnao1 Adcy3 Ppp2ca Prkar2b Prkar2a Ppp2r1a Gnat2 Gnaz Gnai2 Gnb3 Gnb5 Ppp2r1b Gnb2 Gnb1 Gng13 Gng12 Gng11 Mapk1 Prkaca Prkacb Prkca LOC100912034 Gnb4 Camk4 Gng4 Adrbk1 Gngt2 Gnai1 Gng5 Gngt1 Gng8 Gng3 SIGNALING BY ERBB2%REACTOME%R-RNO-1227986.1 Signaling by ERBB2 Prkcd Ptpn18 Ereg Rnf41 Nrg1 Src Kras Btc Grb7 LOC102552659 Erbb3 Pik3r1 Erbb2 Nrg3 Matk Egfr Hbegf Akt1 Ptk6 Nrg4 Memo1 Stub1 Gab1 Fyn LOC103692716 Akt3 Diaph1 Rhoa Prkca Erbb4 Hras Yes1 Nras Sos1 Ptpn12 Usp8 Shc1 Akt2 Nrg2 Grb2 PHASE 0 - RAPID DEPOLARISATION%REACTOME DATABASE ID RELEASE 66%10146067 Phase 0 - rapid depolarisation Camk2g Cacna1c Cacng7 Cacna1d Cacng1 Camk2d Cacng5 Camk2a Scn2a Scn7a Scn4b Scn2b Fgf11 Scn9a Fgf12 Fgf13 Scn10a Scn4a Scn5a Fgf14 Scn3a Scn11a Rangrf Scn1b Cacnb4 Cacnb1 Cacng8 Cacnb2 Cacna2d3 Cacna1f Cacna1s Cacng2 Cacng3 Cacna2d2 Cacng4 Cacna2d4 MISCELLANEOUS SUBSTRATES%REACTOME DATABASE ID RELEASE 66%10145442 Miscellaneous substrates Cyp4a2 Cyp2s1 Cyp4f39 Cyp4a1 Cyp3a23/3a1 Cyp3a73 Cyp2d5 Cyp4f6 Cyp2u1 Cyp4a8 LOC100912391 Cyp2d4 Cyp3a18 Cyp4f17 LOC100910877 Cyp2d2 Cyp2d3 Cyp4f18 HATS ACETYLATE HISTONES%REACTOME%R-RNO-3214847.1 HATs acetylate histones Atf2 Phf20 Mcrs1 Hist1h2bo Kat7 Hist1h2bcl1 Kansl3 Hist2h3c2 Jade1 Hist1h2bk Jade3 Hat1 Jade2 Kat8 Msl3 Ogt Msl1 Ncoa1 Msl2 Meaf6 LOC100910200 Hist1h4b Wdr5 Pax3 LOC684841 Hist1h2bh LOC100912290 Rbbp7 Hist1h2ail1 Hist1h4m LOC102549173 LOC100912338 Msl3l2 Hist1h3c Hist1h3f Brpf3 Hist2h4 LOC684819 Hist1h3a Brpf1 Brd1 Hist1h2bq Kat6a Ing4 LOC100364835 LOC684762 Ing5 Ncoa2 Hist1h2bg LOC680097 LOC684797 LOC100912418 Hist1h2ba Hist3h2bb REGULATION OF IFNA SIGNALING%REACTOME%R-RNO-912694.1 Regulation of IFNA signaling Stat1 Jak1 Stat2 Ptpn1 Ifnar2 Ifna5 Ifna4 Ptpn11 LOC100912356 LOC100911527 Ifna11 Ptpn6 LOC100912859 Usp18 Ifnar1 RGD1560539 Ifna2 Ifnb1 LOC103690314 LOC100912314 Tyk2 Ifna16l1 RGD1565911 RGD1561827 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES%REACTOME%R-RNO-1169410.1 Antiviral mechanism by IFN-stimulated genes LOC100912571 Stat1 Irf3 Jak1 Eif4e2 Pde12 Arih1 Oasl Rnasel Abce1 Ddx58 Uba7 LOC100911431 Ube2l6 Eif4g1 Eif4a3 Eif4g2 Eif4g3 Flnb Isg15 Trim25 Eif2ak2 Ppm1b Usp18 Ube2n Eif4e3 Plcg1 Mx1 Eif4a2 Mx2 Eif4a1 LOC680559 SIGNALING BY NOTCH4%REACTOME DATABASE ID RELEASE 66%10146330 Signaling by NOTCH4 Ywhaz Notch4 Akt1 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM%REACTOME DATABASE ID RELEASE 66%10144804 Cobalamin (Cbl, vitamin B12) transport and metabolism LOC102554637 Mtrr Try4 Prss2 Mtr LOC103690254 Mut LOC688708 Try10 LOC100365995 Cubn Amn Mmadhc Abcd4 Cd320 Mmab Tcn2 Mmaa Mmachc Prss1 LOC683849 Ctrc Lmbrd1 ASSEMBLY OF ACTIVE LPL AND LIPC LIPASE COMPLEXES%REACTOME DATABASE ID RELEASE 66%10146149 Assembly of active LPL and LIPC lipase complexes Angptl4 LOC100361444 Lmf1 Lmf2 Lpl Gpihbp1 Pcsk6 Pcsk5 Furin SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX)%REACTOME%R-RNO-2162123.1 Synthesis of Prostaglandins (PG) and Thromboxanes (TX) Ptgds Tbxas1 Ptgis Akr1c2 Akr1c12l1 Akr1c3 Ptges Ptges3 Cyp8b1 Ptges3l1 Cbr1 Ptges2 Hpgds LOC102556347 Akr1c19 Ptgs1 Akr1c13 Ptgs2 Akr1c14 RGD1564865 Akr1c12 Akr1c1 INTERLEUKIN-38 SIGNALING%REACTOME DATABASE ID RELEASE 66%10146291 Interleukin-38 signaling Il1rapl1 Mapk8 Il1rl2 Il1f10 AUF1 (HNRNP D0) BINDS AND DESTABILIZES MRNA%REACTOME DATABASE ID RELEASE 66%10145697 AUF1 (hnRNP D0) binds and destabilizes mRNA LOC100912571 Psmc6 Psmb10 Psmb8 Psmb9 Psmb4 Psmb11 Psmb5 Psmf1 Psmb6 Psmd4 Psmb2 Psmd5 Psmd8 Psmd9 Psmb3 Psma8 Psmd11 Psmd12 Psmd13 Eif4g1 Psmd14 Pabpc2 Pabpc6 Psmc3 LOC680559 Hspb1 G6pc Psmb7 Psmb1 LOC100911431 Pabpc1 Hnrpd Psma5 Psma2 Psmc5 Psmd2 Psma1 Psma4 Psmc1 Psma3 Psmc4 Psmc2 Psma6 Psme1 Psmd1 Psme2 Psmd7 Psmd3 Psmd6 CYTOKINE SIGNALING IN IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 66%10145164 Cytokine Signaling in Immune system Il21r Il21 Pde12 Pias1 Oasl Rnasel Abce1 Rbx1 Socs5 Socs3 Uba7 Vamp2 Casp3 Ube2l6 Tnf Fyn Sumo1 Stat6 Il1rl2 Il36rn Il1f10 Il1rap Il36b Il36a Sqstm1 Stx4 Ube2n Ptk2b Il1rl1 Brwd1 Pik3cd Irak4 Crk Ifnar2 Ifna5 Stx1a Traf2 Ifna4 LOC100912356 LOC100911527 Ifna11 LOC100912859 Ifnar1 RGD1560539 Lyn Ifna2 Crkl Ifnb1 Yes1 LOC103690314 Hck LOC100912314 Rapgef1 Ifna16l1 RGD1565911 Syk RGD1561827 LOC100911248 Map2k7 Camk2g Ripk2 Tbk1 Map2k6 Ager Dusp3 Irf3 Map2k4 Map3k8 Dusp4 Peli3 Nfkbib Peli2 Camk2d Traf6 Cul1 Camk2a Vrk3 Rps6ka2 Rps6ka1 App Rps6ka3 Il33 Rps6ka5 Canx LOC100912585 Tab1 Dusp7 Dusp6 Rela Atf1 Atf2 Map3k7 Peli1 Irak2 Traf3 Ptpn2 Nfkbia LOC100910771 Usp18 Irf9 Tnfsf13b Tnfrsf9 Tnfrsf8 Il2rg Edaradd Tnfrsf4 G6pc Eda2r Ifngr2 Ifngr1 Cd70 Tnfrsf17 Tnfsf8 Tnfsf9 Tnfrsf25 Edar Psmb7 Prmt2 Psmb1 Tnfrsf11b Tnfrsf11a Tnfsf4 Tnfsf14 Tnfsf12 Tnfrsf12a Tnfrsf13c Eda Tnfsf11 Lta Ltb Vav1 Ltbr Il9r Cd27 Il15 Ifng Il9 P4hb Psma5 Tollip Sos2 Psma2 Il10ra Il10 Il5 Psmd2 Il2 Ptpn6 Psmc2 Il2ra Psmd1 Csf2 Il3ra Psmd7 Psmd3 Il2rb Psmd6 LOC100912571 Psmc6 Csf2ra Csf2rb Psmb10 Psmb8 Psmb9 Psmb4 Sh2b1 Psmb11 Ptpn1 Psmb5 Gh1 Psmf1 Il5ra Ghr Psmb6 Psmd4 Psmb2 Psmd5 Psmd8 Psmd9 Psmb3 Psma8 Prl Psmd11 Psmd12 Psmd13 Psmd14 Eif4g1 Csf1 Psmc3 Il1b Eif4a2 Eif4a1 LOC680559 Pik3r3 Inpp5d Jun Ppp2cb Ppp2ca Skp1 Ppp2r1a Ywhaz Nfkb2 Nfkb1 Mapk9 Mapk8 Fos S100b Mapk7 Dhx9 Fbxw11 Chuk Ppp2r1b Mapkapk3 Eif4a3 Btrc Mapkapk2 Mapk1 Nkiras1 Prkaca LOC100362142 Nod1 Nod2 Nkiras2 Creb1 Tab2 Tab3 LOC100912618 Ube2v1 Ikbkb Mapk14 Myd88 Tnip2 Mapk11 Tnfsf13 Mapk10 Stat5a Jak3 Il22 Il24 Il19 Stat1 Il22ra1 Jak1 Cd40 Stat2 Stat3 Il10rb Hsp90b1 Cd4 Hist2h3c2 Cd40lg Irs2 Ube2m Cbl Smarca4 Il13ra1 Eif4g2 Clcf1 Eif4g3 Flnb Il13ra2 Isg15 Trim25 Il12b Eif2ak2 Il31ra Ppm1b Irak3 Eif4e3 Il12a Mx1 Il22ra2 LOC100360218 Mx2 Cntf Il20ra Irs1 Csf3 Il20rb Il23r Il1r1 Tyk2 Crlf2 Ifnl3 Il20 Ebi3 Ifnlr1 Il4r Prkcd Il17c Il1rapl1 Map3k3 Il17a Birc3 Il23a Birc2 Crlf1 LOC684841 Il4 Pik3r1 Il6 Lif Il6st Pik3r2 Stxbp2 Eif4e2 Csf1r Arih1 Ptprz1 Hist1h2ail1 Il13 LOC102549173 Tnfrsf14 Txlna Il11ra1 Lifr Il18r1 Il12rb1 Ddx58 Hist1h3c Il12rb2 Csf3r Hist1h3f Il17rc Il11 Stx3 Il18 LOC684819 Hist1h3a Il16 Ctf1 LOC100911431 Il1a Casp1 Il25 Osmr Il17rb Il17ra Il17re Il27ra LOC684762 Socs1 Cntfr Osm Tnfrsf1b Psmc5 Psma1 Uba3 Pik3cb Map3k14 Psma4 Ptpn11 Relb Psmc1 Tec Psma3 Psmc4 Psma6 Psme1 Plcg1 Psme2 Sos1 Vamp7 Shc1 Grb2 FORMATION OF A POOL OF FREE 40S SUBUNITS%REACTOME%R-RNO-72689.1 Formation of a pool of free 40S subunits Eif3l Eif3m Eif3j Eif3k Rps20 Rps27l Eif3e Eif3f Eif3b Eif3a Eif3d Eif3c Rps16 LOC100360573 Rps18 LOC100360679 Rps15 Rps4x Rps3a LOC100359951 LOC100359593 LOC100359503 LOC100362640 Rps3 Rps15a Rps2 Rps13 Rps12 LOC100911372 LOC100361854 LOC684988 LOC103689992 Rps5 Rps7 Rps6 Eif3g Eif3h LOC100362830 Eif1ax LOC100363012 LOC100911110 LOC100362149 LRR FLII-INTERACTING PROTEIN 1 (LRRFIP1) ACTIVATES TYPE I IFN PRODUCTION%REACTOME%R-RNO-3134973.1 LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production Irf3 Crebbp DISSOLUTION OF FIBRIN CLOT%REACTOME DATABASE ID RELEASE 66%10145082 Dissolution of Fibrin Clot Plau Plaur Serpinb8 Plg Serpine2 Plat S100a10 Serpine1 Serpinb2 Serpinb6b Serpinb6 Anxa2 RESOLUTION OF D-LOOP STRUCTURES THROUGH HOLLIDAY JUNCTION INTERMEDIATES%REACTOME%R-RNO-5693568.1 Resolution of D-loop Structures through Holliday Junction Intermediates Bard1 Wrn Rbbp8 Rmi1 Rmi2 Rad51c LOC100911267 Rad51d Spidr Rad51 Eme2 Brca2 Eme1 Rad50 Atm Brca1 Xrcc3 Blm Slx4 Mus81 Slx1b Slc25a16 Palb2 Gen1 Xrcc2 Nbn Mre11a RETINOID METABOLISM AND TRANSPORT%REACTOME DATABASE ID RELEASE 66%10145777 Retinoid metabolism and transport Agrn Gpihbp1 Pnlip Akr1b7 Akr1b8 Apoa1 Sdc2 Sdc3 Sdc4 Clps Gpc6 Akr1c2 Gpc4 Gpc2 Rbp4 Akr1c12l1 Akr1c3 Ttr Lrp1 Lrp10 Rbp2 Tex12 Rbp1 Lrp8 Apom Lrp12 Lpl Akr1c19 Apob Bco1 Apoc2 Rdh11 Apoe Apoa2 Lrat Bco2 Gpc1 Akr1c13 Akr1c14 RGD1564865 Akr1c12 Akr1c1 METABOLISM OF VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 66%10144806 Metabolism of vitamins and cofactors Nos3 Mmadhc Abcd4 Sdc2 Slc46a1 Sdc3 Cd320 Sdc4 Mmab Tcn2 Mmachc LOC683849 Ctrc Lmbrd1 Spr Akr1c12l1 Ttr Akr1c19 Akr1c13 Akr1c14 RGD1564865 Akr1c12 Fasn Acacb Slc5a6 Nnmt Nt5e Mccc2 Pdzd11 Mtrr Hlcs Pnlip Mccc1 Gsto1 Mtr LOC103690254 Akt1 Mut Try10 LOC100365995 Cubn Amn Apoa1 Clps Gpc6 Gpc4 Gpc2 Naprt1 Ptgs2 Gpc1 Mmaa Ptgis Try4 Pdss2 Coq2 LOC688708 Rfk Akr1b7 Pdxk LOC100911034 Akr1b8 Pts Apoa1bp Gsto2 Vnn1 Tpk1 Rnls Carkd Slc52a2 Slc52a3 Slc23a2 Pc Gch1 Nampt Mocs1 Cd38 Enpp1 Parp14 LOC100910173 Nudt12 Akr1c2 Nmnat2 Nmnat1 Acp5 Mocos Akr1c3 Ubiad1 Nmrk1 LOC103692716 Nmrk2 Prss2 Nfs1 Nadsyn1 Cyb5a Gchfr Pank4 Flad1 Parp9 Coasy Mocs3 Pank3 Pank2 Parp6 RGD1563242 Apob Ppcs Pank1 Apoc2 Thtpa Parp8 Apoe LOC100362038 Qprt Apoa2 Aasdhppt Folr2 Slc19a2 Nadk Prss1 Akr1c1 Slc25a19 Agrn Aox1 Pnpo Gpihbp1 Ppcdc Prkg2 Mthfs Mthfd1l Mthfd2l LOC102554637 Dhfr Mthfr Slc5a8 Mthfd2 Rbp4 Mthfd1 Shmt1 Aldh1l2 Lrp1 Aldh1l1 Lrp10 Slc19a1 Rbp2 Tex12 Slc25a32 Cyp8b1 Shmt2 Rbp1 Lrp8 Ttpa Apom Idh1 Lrp12 Lpl Bst1 Bco1 Rdh11 Lrat Pccb Slc2a1 Cyb5r3 Bco2 FIBRONECTIN MATRIX FORMATION%REACTOME%R-RNO-1566977.1 Fibronectin matrix formation Fn1 Ceacam1 Ceacam10 RMTS METHYLATE HISTONE ARGININES%REACTOME%R-RNO-3214858.1 RMTs methylate histone arginines Prmt3 Prmt5 Prmt6 Prmt7 Actl6a Hist2h3c2 Carm1 Rps2 Smarca4 Prmt1 Smarca2 LOC100911617 Arid2 Smarcc1 Smarcc2 Coprs Smarcb1 Actl6b H2afx Hist1h2aa Hist1h4b Smarce1 Wdr5 Pbrm1 LOC684841 Arid1b Arid1a LOC100912290 Rbbp7 Hist1h2ail1 Hist1h4m LOC102549173 Cdk4 LOC103690002 LOC100910152 Dnmt3a Smarcd1 Hist1h3c Smarcd2 H2afb3 Smarcd3 Hist1h3f Hist2h4 Ccnd1 LOC684819 Hist1h3a H2afj Hist2h2aa3 LOC100911453 Hist2h2aa2 Wdr77 LOC684762 LOC680097 LOC100912418 AMPK INHIBITS CHREBP TRANSCRIPTIONAL ACTIVATION ACTIVITY%REACTOME DATABASE ID RELEASE 66%10145123 AMPK inhibits chREBP transcriptional activation activity Adipor1 Adipor2 Adipoq Prkab2 Prkaa2 MAPK FAMILY SIGNALING CASCADES%REACTOME%R-RNO-5683057.1 MAPK family signaling cascades Ereg Nrg1 Btc LOC102552659 Erbb3 Erbb2 Nrg3 Egfr Hbegf Nrg4 Fyn Mapkapk5 Ptk2 Nrg2 Hspb1 Shc2 Ranbp9 Pdgfa Pdgfb Foxo1 Foxo3 Cdc14a Tln1 Vwf Apbb1ip Rasa1 Dlg4 Grin2d Camk2g Grin2b Grin1 Nefl Rasgrf1 Dusp4 Dlg1 Dlg2 Frs3 Dlg3 Camk2d Actn2 Camk2a Dusp7 Dusp6 Fgb Ret Fgg LOC100909468 Hgf Xpo1 Pak2 Pak3 Fga Pak1 Gdnf Map2k2 Pspn Cdc14b Mapk4 Cdc42ep5 Cdc42ep3 Ppp2r5e Etv4 Il2rg Cdc42ep2 G6pc Pdgfra Pdgfrb Mapk6 Psmb7 Psmb1 Ppp2r5c Spta1 Lrrc7 Ppp2r5a Kalrn Gfra4 Gfra3 Ppp2r5b Gfra2 Pbp2 Fn1 Artn Dusp9 Dusp2 Shc3 Dusp5 Nrtn Ptpra Rasal3 Psma5 Csk Rasal1 Rasal2 Rasgrp1 Rap1a Ncam1 Pebp1 Sptbn1 Rasgrp4 Rasgrp3 Pea15 Dusp1 Mark3 Psma2 Araf Cdc42 Rasa4 Il5 Psmd2 Spred1 Spred2 Rasgef1a Il2 Psmc2 Rasa2 Rasa3 Itga2b Il2ra Csf2 Psmd1 Il3ra Psmd7 Nf1 Iqgap1 Kit Syngap1 Kitlg Psmd3 Il2rb Psmd6 Dusp16 Map3k11 Psmc6 Csf2ra Csf2rb Psmb10 Ksr1 Rapgef2 Psmb8 Wdr83 Psmb9 Ksr2 Raf1 Psmb4 Ppp5c Psmb11 Il17rd Psmb5 Psmf1 Il5ra Cnksr1 Psmb6 Cnksr2 Rac1 Psmd4 Dusp10 Psmb2 Paqr3 Psmd5 Psmd8 Psmd9 Psmb3 Psma8 Psmd11 Psmd12 Psmd13 Psmd14 Fgf2 Psmc3 Src Dnajb1 Ppp2cb Ppp2ca Ppp2r1a Ywhab Ppp2r1b Mapk1 Prkaca Prkacb Jak3 Jak1 Vcl Sptan1 Fgf23 Fgf22 Fgf4 Fgf1 Fgf3 Fgf6 Fgf5 Lamtor3 Fgf20 Fgf16 Lamtor2 Fgf17 Irs2 Fgf10 Fgf9 Fgfr2 Fgf7 Fgf8 Fgfr3 Fgfr1 Fgfr4 Fgf19 Erbb4 Irs1 Frs2 Tyk2 Ccnd3 Kras Il6st Il6 Cdk1 Psmc5 Arrb1 Psma1 Tek Psma4 Psmc1 Arrb2 Ptpn11 Psma3 Psmc4 Lat Psma6 Psme1 Angpt1 Psme2 Hras Nras Sos1 Shc1 Grb2 ACTIVATION OF NIMA KINASES NEK9, NEK6, NEK7%REACTOME%R-RNO-2980767.1 Activation of NIMA Kinases NEK9, NEK6, NEK7 Nek6 Cdk1 Nek7 CYSTEINE FORMATION FROM HOMOCYSTEINE%REACTOME%R-RNO-1614603.1 Cysteine formation from homocysteine Cbs Cth NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION)%REACTOME%R-RNO-198725.1 Nuclear Events (kinase and transcription factor activation) Dusp3 Mapk7 Dusp4 Ppp2r1b Mapkapk2 Mapk1 Vrk3 Rps6ka2 Rps6ka1 Rps6ka3 Ppp2cb Rps6ka5 Creb1 Ppp2ca LOC100912585 Ppp2r1a Dusp7 Dusp6 Atf1 Mapk14 Mapk11 PYRIMIDINE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 66%10144841 Pyrimidine biosynthesis Cad Umps Dhodh ADAPTIVE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 66%10145356 Adaptive Immune System Rnf41 Kif3c Racgap1 Kif22 Kif3b Vhl Kif23 Stim1 Kifap3 Kif11 Kif4a Rbx1 Socs3 RGD1308751 Itga4 Dnm2 Rbck1 Fyn Ube2v2 Ube2n Rap1gap2 Sipa1 Pik3ap1 Ube2d1 Vcam1 Akt1 Herc2 Ube2d3 Stub1 Calr MGC114246 Cd101 Testin Kif26a Kif20a Lyn Yes1 Syk Trim21 Map3k8 Trim32 Nfkbib Traf6 Itgb7 Cul1 Madcam1 Itgb2 Wwp1 Atg7 Canx Rela Map3k7 Ctsa Ptprc Prkcq Siah1 Siah2 Vamp8 LOC100364523 Sar1b Sh3gl2 Nfkbia LOC100910771 Sh3kbp1 Itgal LOC685953 Icam4 Cd36 Ctsc Icam5 Icam1 Rap1gap Ctsd Psmb7 Ctsb Psmb1 Trem2 Ctsl Ctsm Ctsj RGD1564657 Ctsk Ctsq Vav1 Ctsr Psma5 Csk Dnm1 Dnm3 Rap1a Rasgrp1 Rasgrp3 Psma2 Psmd2 Cts8 Cts7 Ptpn6 Psmc2 Psmd1 Psmd7 RGD1564827 Ppl Icam2 Psmd3 Psmd6 Pten Raf1 Fbxl19 Fbxl12 Fbxl13 Fbxl16 Fbxl15 Cts8l1 Rasgrp2 Ube2z Kif3a Ube2s Fbxl4 Fbxl5 Fbxl8 Pik3r3 Inpp5d Cd3e Ppp2cb RT1-Ba Ppp2ca RT1-Bb Skp1 RT1-Da RT1-Db2 Ppp2r1a RT1-Db1 LOC688090 Mtor Nfkb1 Fbxw11 Chuk Ppp2r1b Mlst8 Btrc Akt3 LOC100362142 Tab2 LOC100912618 Ube2v1 Ikbkb Cd80 Cd86 Lgmn Colec12 Ap1m2 Trem1 Ifitm3 Cd40lg Cd226 Smurf1 LOC100911324 Pvrl2 Ifitm2 Ifitm1 Sh2d1a Sh2d1b Ube2m Cd8b Cd8a RGD1561143 Slamf7 Siglec10 Slamf6 Npdc1 Treml2 Cd200r1 Cd200r1l LOC681182 Cd96 Dctn1 Dctn2 Dctn3 RT1-DMa RT1-DMb Cd74 Lag3 Rilp Ifi30 LOC100909593 LOC100909630 RT1-DOb RT1-DOa Ctse Ctsf RGD1560225 Ppp3ca Nfatc2 Lat Plcg1 Nfatc3 Actr1a Lcp2 Itk Klc1 Sec24a Sec24b Dync1li2 Sec24d Asb18 Asb11 Asb12 Asb13 Asb14 Dync1i2 Asb10 Keap1 Uba7 Nck1 Traf7 Asb15 Glmn Asb17 Uba5 Asb16 Hecw2 Klc4 Mrc2 Ube2l6 Rbbp6 Mrc1 Cenpe Ube3d Klc2 Ube3b Trim11 Klc3 Lrsam1 Ube3a Npepps Ube2o Ube2u Hectd3 RT1-A2 Hectd1 Rnf6 RT1-A1 Erap1 Ncf1 Ncf4 Rnf4 Cd207 B2m Tap1 Tap2 Traip Rnf25 Ap1b1 Anapc13 RGD1561778 Lnx1 Dynll2 Rnf19a Rnf19b Herc3 Arih2 Herc6 Tapbp Stx4 Tpp2 Dync1i1 Ubox5 Ube2j2 Arel1 Ube2j1 Sec24c Rnf182 Rnf14 Ltn1 Cblb Sh3rf1 Pja1 Pja2 Dtx3l LOC100911393 Znrf2 Znrf1 Trim9 Blmh LOC100911400 Rnf115 Ptpn22 Trim63 Dzip3 Trip12 Ubr2 Trim71 Vprbp Trim69 Trim39 Ube4a LOC100910646 Ufl1 Trim50 Ubac1 Ube2q1 Thop1 Rlim Mex3c Rchy1 Pik3cd Mgrn1 Trim41 Hace1 Trim36 Trim37 Anapc7 Fcgr1a Cdc26 Cd247 Cdc27 Cdc23 Fbxl22 Rnf144b Lrrc41 Ube2c Skp2 Fbxw10 Cdc16 Fbxw12 Anapc4 Anapc2 Anapc1 Ap1s3 Ap1s1 Ap1s2 Fyb Anapc11 Anapc10 Fzr1 Cd19 Cd81 LOC100909468 Sec13 Pak2 Pak3 Pak1 Ppp2r5e G6pc Klhl5 Cdc20 Kif2a Kif2c Kif2b Kif18a Ppp2r5c Ppp2r5a Ppp2r5b Xdh Capzb Cd209b Kif5b Cd209e Klhl2 Btn2a2 Kif5a Clec4m Fbxo2 Cd79b Cd79a Fbxo9 Was Nfkbie Blnk Fbxo7 Btn1a1 LOC684480 Fbxo6 Cd209a Fbxo4 Btnl2 Dapp1 Cd79al Ube2k Ube2h Ube2f Sec31a Pdpk1 Ube2a Cdc42 Klhl9 Lrr1 Psmc6 Psmb10 Psmb8 Psmb9 Rnf123 Psmb4 Psmb11 Psmb5 Psmf1 Psmb6 Psmd4 Rac1 Psmb2 Psmd5 Psmd8 Psmd9 Psmb3 Psma8 Ccnf Psmd11 Psmd12 Ube2e3 Psmd13 Psmd14 Rictor Ap2a2 RT1-M3-1 Tceb2 Tceb1 Cul2 Psmc3 LOC100364500 RT1-S3 Bcl10 RT1-CE2 Kctd7 Src RT1-CE3 RT1-CE4 RT1-CE7 Rnf7 RT1-CE5 RT1-CE10 Cltc Rab7a Clta Prkcb Ywhaz Ap2s1 Kbtbd8 Ppp3r1 Kbtbd7 Ap2a1 Ywhab Kbtbd6 Ap2m1 Kctd6 Ube2q2 Ube2r2 Hspa5 Capza2 Capza3 LOC683761 Gan LOC100364956 Prkaca Prkacb Itpr1 Rapgef4 Itpr3 PVR Cd40 Cd34 Fbxl18 Siglec1 Mill1 Fbxl7 LOC680910 LOC685157 Cd200 Hcst Cd300lb Asb5 Cd300le Asb6 Kir3dl1 Asb7 Pianp Klhl41 Cd300e Cd300lg Asb1 Asb3 Cd1d1 Cd300lf Cdc34 Cd4 Asb8 Crtam LOC685048 Actr10 RGD1559588 Sh2d1b2 Klhl42 Pilra RT1-A Cd22 RGD1566006 LOC685438 Dync1h1 Dync1li1 Fbxo41 Fbxo44 Fbxo40 RGD1565355 Trib3 Cybb Cyba Wsb1 Actr1b Dctn5 RT1-M2 Dctn6 Spsb2 RT1-M5 Spsb1 RT1-M4 Ubr4 Them4 Dctn4 Spsb4 Btbd1 Akt2 Btbd6 Fbxo22 Ube2g2 Ube2g1 Kras Pik3r1 Pik3r2 Klhl13 Fbxo30 Pdcd1lg2 Fbxo31 Tnfrsf14 Klhl11 Ptprj Btla Fbxo32 Fbxo21 Icoslg Cd28 Pdcd1 Klhl20 Ap1m1 Cd274 LOC100911478 Icos Zbtb16 Klhl25 Klhl21 Uba1 Klhl22 Fbxo10 Socs1 Fbxo15 Fbxo11 Sec22b Sec23a RGD1559482 Fbxw2 C3 Mylip RT1-M6-1 Uba6 Lair1 Rnf34 Mapkap1 Psmc5 Cd3g Fbxw9 Psma1 Pik3cb Uba3 Psma4 RT1-M6-2 Map3k14 Psmc1 Ptpn11 Cd3d Fbxw5 Psma3 Fbxw4 Psmc4 Fbxw8 Psma6 Fbxw7 Psme1 Psme2 Hras Nras Sos1 Vamp3 LOC100909844 Grb2 RAF-INDEPENDENT MAPK1 3 ACTIVATION%REACTOME DATABASE ID RELEASE 66%10144960 RAF-independent MAPK1 3 activation Dusp16 Dusp9 Dusp2 Dusp5 Jak1 Il6st Dusp4 Il6 Cdk1 Pea15 Dusp1 Dusp10 Mapk1 Ptpn11 Dusp7 Dusp6 Tyk2 Map2k2 RNA POLYMERASE II TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 66%10144832 RNA Polymerase II Transcription Termination Rnps1 Thoc5 Thoc7 Thoc3 Snrpf Thoc2 Thoc1 Wdr33 Magohb Rbm8a Pcf11 Fip1l1 Thoc6 Nudt21 Zfp473 Snrpd3 Ddx39a Cstf2 Ddx39b Chtop U2af1l4 Cpsf7 Cpsf2 Cpsf3 Cpsf4 Cstf1 Cpsf1 Sarnp Slu7 Srsf3 Upf3b U2af2 Papola Srsf6 Srsf7 Srsf4 Lsm10 Lsm11 Srsf5 Srsf2 LOC679894 Srsf9 Dhx38 Clp1 Magoh Ncbp2 Srsf1 Poldip3 Ncbp1 Cstf2t Eif4a3 Fyttd1 Sympk Slbp LOC100910660 Srrm1 Cdc40 LOC361990 Snrpb SYNTHESIS OF KETONE BODIES%REACTOME%R-RNO-77111.1 Synthesis of Ketone Bodies Hmgcll1 Aacs Bdh2 Acat1 Hmgcs2 Hmgcl Acss3 LACTOSE SYNTHESIS%REACTOME DATABASE ID RELEASE 66%10146097 Lactose synthesis Slc2a1 Lalba B4galt1 DOWNSTREAM SIGNALING OF ACTIVATED FGFR4%REACTOME DATABASE ID RELEASE 66%10145261 Downstream signaling of activated FGFR4 Kras Pik3r1 Frs3 Fgf23 Fgf22 Fgf4 Fgf1 Fgf3 Fgf6 Fgf5 Fgf20 Gab1 Fgf16 Fgf17 Fgf10 Fgf9 Fgfr2 Fgf7 Fgf2 Fgf8 Fgfr3 Fgfr1 Fgfr4 Ptpn11 Plcg1 Fgf19 Hras Nras Frs2 Sos1 Shc1 Grb2 VXPX CARGO-TARGETING TO CILIUM%REACTOME DATABASE ID RELEASE 66%10146083 VxPx cargo-targeting to cilium Exoc8 Exoc7 Rab11a Rab3ip Arf4 Pkd2 Pkd1 Rab8a Cnga4 Cnga2 Cngb1 Gbf1 Exoc3 Exoc2 Exoc1 Exoc6 Exoc5 THE ROLE OF GTSE1 IN G2 M PROGRESSION AFTER G2 CHECKPOINT%REACTOME%R-RNO-8852276.1 The role of GTSE1 in G2 M progression after G2 checkpoint Psmc6 Psmb10 Psmb8 Psmb9 Psmb4 Psmb11 Fkbpl Psmb5 Psmf1 Psmb6 Psmd4 Psmb2 Psmd5 Psmd8 Psmd9 Psmb3 Psma8 Psmd11 Psmd12 Psmd13 Psmd14 LOC103692716 Psmc3 G6pc Hsp90ab1 Psmb7 Psmb1 Psma5 Cdkn1a LOC100910954 Cdk1 Mapre1 Psma2 Psmc5 Gtse1 Psmd2 Psma1 Psma4 Psmc1 Psma3 Psmc4 Psmc2 Psma6 Psme1 Psmd1 Psme2 Psmd7 Psmd3 Psmd6 TWIK-RELATED SPINAL CORD K+ CHANNEL (TRESK)%REACTOME DATABASE ID RELEASE 66%10145846 TWIK-related spinal cord K+ channel (TRESK) Kcnk18 NEUROTRANSMITTER RELEASE CYCLE%REACTOME%R-RNO-112310.1 Neurotransmitter release cycle Slc6a11 Chat Slc6a13 Slc6a1 Slc6a12 Slc1a3 Slc1a7 Rab3a Slc1a6 Slc1a1 Rims1 Lin7c Cplx1 Lin7a Syn3 Syt1 Syn2 Vamp2 Stxbp1 Ppfia1 Slc32a1 Ppfia2 Ppfia3 Ppfia4 Bzrap1 Syn1 Apba1 Lin7b Dnajc5 Gad2 Slc38a2 Gad1 Slc17a7 Abat Aldh5a1 Naaa Stx1a Maoa Slc22a1 Slc22a2 Slc5a7 FREE FATTY ACID RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145661 Free fatty acid receptors Gpr31 Ffar2 Ffar3 Ffar1 MAPK1 (ERK2) ACTIVATION%REACTOME DATABASE ID RELEASE 66%10144963 MAPK1 (ERK2) activation Ptpn11 Il6st Jak1 Il6 Tyk2 Map2k2 Mapk1 PROCESSING AND ACTIVATION OF SUMO%REACTOME%R-RNO-3215018.1 Processing and activation of SUMO Senp2 LOC690251 Rwdd3 Senp1 Sumo1 Sae1 Ube2i Sumo3 Senp5 Uba2 RNA POLYMERASE II TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 66%10144905 RNA Polymerase II Transcription Initiation Gtf2h1 Gtf2h2 Gtf2e1 Gtf2e2 Mnat1 RGD1565904 Taf11 Polr2g Ercc3 Taf2 Polr2h Taf15 Polr2e Polr2f Polr2j Taf13 Taf9 Polr2k Taf12 Polr2d LOC100911822 Taf7 Polr2i Taf4b Polr2b Polr2c Taf3 Ercc2 Taf6 Polr2a Taf5 Gtf2f1 LOC100912534 Gtf2f2 Gtf2a1 Cdk7 Atp5c1 Taf10 Taf7l Gtf2b Ccnh Gtf2h3 Gtf2h5 Tbp Gtf2h4 Taf9b RUNX3 REGULATES WNT SIGNALING%REACTOME DATABASE ID RELEASE 66%10146277 RUNX3 regulates WNT signaling Tcf7 Lef1 Tcf7l1 FORMATION OF EDITOSOMES BY ADAR PROTEINS%REACTOME%R-RNO-77042.1 Formation of editosomes by ADAR proteins Adarb1 Adar ARACHIDONIC ACID METABOLISM%REACTOME%R-RNO-2142753.1 Arachidonic acid metabolism Cyp1b1 Cyp4a2 Ptgds Cyp4a1 Ptgis Dpep3 Aloxe3 Dpep1 Cyp4a8 LOC688708 Pla2g4a LOC102556347 Cyp2j10 Alox5ap Awat1 Akr1c2 Akr1c12l1 Akr1c3 Ptges3 Ptges3l1 Hpgds Akr1c19 Cyp4f17 Akr1c13 Akr1c14 RGD1564865 Akr1c12 Akr1c1 Cyp4f18 Tbxas1 Cyp4f39 Dpep2 Ptges Faah Ptges2 Pon3 Pon1 Pon2 Alox5 Lta4h LOC100361547 Gpx4 Cyp2u1 Cyp4f6 Mapkapk2 Cyp8b1 Cyp2c7 Cbr1 Alox15b Alox12 Ltc4s LOC100912391 Cyp1a1 Ptgs1 Ptgs2 Ephx2 Cyp1a2 Alox15 Cyp2c6v1 ION TRANSPORT BY P-TYPE ATPASES%REACTOME%R-RNO-936837.1 Ion transport by P-type ATPases Fxyd2 Camk2g Fxyd3 Fxyd4 Atp2b4 Pdzd11 Atp10b Atp11c Atp2b2 Sri Atp2b1 Sln Camk2d Camk2a Atp9b Atp7a Atp2a2 Fxyd6 Atp7b Atp10d Pln Fxyd7 Atp2a3 Atp1b3 Atp1b2 Atp1b1 Atp8b3 Atp8b2 Atp8b1 Atp8a1 Atp2c2 Atp2c1 Atp11a Atp12a Atp13a5 Atp13a4 Atp13a2 Atp8a2 Atp1a4 Atp4b Atp4a Atp1a1 Atp1a2 Atp13a1 Atp1a3 PI-3K CASCADE:FGFR4%REACTOME%R-RNO-5654720.1 PI-3K cascade:FGFR4 Gab1 Fgf16 Fgf17 Pik3r1 Fgf9 Fgf2 Fgf8 Fgfr4 Fgf23 Fgf4 Ptpn11 Fgf1 Fgf6 Fgf19 Frs2 Fgf20 Grb2 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS%REACTOME DATABASE ID RELEASE 66%10144984 SLBP independent Processing of Histone Pre-mRNAs Ncbp2 Snrpf Zfp473 Snrpd3 Ncbp1 Lsm10 Lsm11 Snrpb G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA%REACTOME%R-RNO-392451.1 G beta:gamma signalling through PI3Kgamma Pik3r5 Pik3r6 Gnb3 Gnb5 Gnb2 Gnb1 Akt1 Pdpk1 Gng13 Gng12 Gng11 Akt3 Rhoa LOC100912034 Gnb4 Gng4 Gngt2 Pik3cg Gng5 Gngt1 Gng10 Gng8 Akt2 Gng3 CLEC7A (DECTIN-1) SIGNALING%REACTOME%R-RNO-5607764.1 CLEC7A (Dectin-1) signaling Psmc6 Psmb10 Psmb8 Psmb9 Psmb4 Psmb11 Psmb5 Psmf1 Psmb6 Traf6 Psmd4 Psmb2 Cul1 Psmd5 Psmd8 Psmd9 Psmb3 Psma8 Psmd11 Cdc34 Psmd12 Tab1 Psmd13 Rela Psmd14 Map3k7 Ube2m Psmc3 Nfkbia Il1b LOC100910771 Ube2n Bcl10 Pycard Prkcd Src G6pc Ube2d1 Psmb7 Psmb1 Skp1 Ppp3r1 Casp8 Nfkb2 Nfkb1 Psma5 Fbxw11 Chuk Btrc Pdpk1 Psma2 RGD1560225 Psmc5 Ppp3ca Psma1 Psmd2 Uba3 LOC100362142 Psma4 Nfatc2 Map3k14 Psmc1 Relb Psma3 Psmc4 Psmc2 Tab2 Psma6 Tab3 Psme1 LOC100912618 Ube2v1 Psmd1 Psme2 Ikbkb Psmd7 Nfatc3 Psmd3 Psmd6 CELL-EXTRACELLULAR MATRIX INTERACTIONS%REACTOME DATABASE ID RELEASE 66%10145642 Cell-extracellular matrix interactions Arhgef6 Ilk Flna Rsu1 Vasp Fblim1 Fermt2 Flnc Actn1 Parvb Lims1 SODIUM PROTON EXCHANGERS%REACTOME%R-RNO-425986.1 Sodium Proton exchangers Slc9a1 Slc9a4 Slc9a5 Slc9a2 Slc9a9 Slc9a3 Slc9a6 Slc9a8 Slc9a7 INTERLEUKIN-7 SIGNALING%REACTOME%R-RNO-1266695.1 Interleukin-7 signaling Stat5a Jak3 Hist2h3c2 LOC684841 Il2rg Irs2 Pik3r3 Pik3r1 Jak1 Pik3r2 Stat3 Hist1h2ail1 Smarca4 LOC102549173 Brwd1 Hist1h3c Hist1h3f LOC684819 Hist1h3a Irs1 Crlf2 LOC684762 ATTACHMENT OF GPI ANCHOR TO UPAR%REACTOME DATABASE ID RELEASE 66%10145107 Attachment of GPI anchor to uPAR Pigk Plaur Pgap1 Pigs Gpaa1 Pigu Pigt ANTIGEN PROCESSING-CROSS PRESENTATION%REACTOME DATABASE ID RELEASE 66%10145813 Antigen processing-Cross presentation Psmc6 Psmb10 Psmb8 Psmb9 Psmb4 Psmb11 Psmb5 Psmf1 Psmb6 Psmd4 Psmb2 Psmd5 Psmd8 Psmd9 Psmb3 Psma8 Psmd11 Psmd12 Mrc2 Psmd13 Mrc1 Psmd14 RT1-A RT1-A2 RT1-M3-1 Ncf1 RT1-A1 Ncf4 Cd207 Tap1 B2m Tap2 RGD1565355 Cybb Cyba Vamp8 Psmc3 RT1-M2 LOC100364500 RT1-M5 Tapbp RT1-M4 Stx4 RT1-S3 LOC685953 RT1-CE2 Cd36 RT1-CE3 RT1-CE4 RT1-CE7 G6pc RT1-CE5 RT1-CE10 Psmb7 Psmb1 Fcgr1a Calr Psma5 Sec22b RT1-M6-1 LOC683761 Psma2 LOC100364956 Psmc5 Psmd2 Psma1 RT1-M6-2 Psma4 Psmc1 Psma3 Psmc4 Psmc2 Psma6 Psme1 Psmd1 Psme2 Psmd7 Vamp3 Psmd3 Psmd6 CALCITONIN-LIKE LIGAND RECEPTORS%REACTOME%R-RNO-419812.1 Calcitonin-like ligand receptors Ramp3 Adm Calcb Iapp Calca Ramp1 Adm2 Ramp2 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER%REACTOME%R-RNO-2173793.1 Transcriptional activity of SMAD2 SMAD3:SMAD4 heterotrimer Smad3 Ccnt2 Smad2 Usp9x Sp1 Ube2d1 Skil Rbl1 Ncor2 Cdk9 E2f4 Men1 Hdac1 Tgif2 Tgif1 Atp1b4 Trim33 Ccnk Ube2d3 Wwtr1 Tfdp1 Tfdp2 Parp1 E2f5 Hdac1l Snw1 P75NTR REGULATES AXONOGENESIS%REACTOME%R-RNO-193697.1 p75NTR regulates axonogenesis Ngf Rhoa Arhgdia Rtn4 Lingo1 Ngfr Omg Mag MET ACTIVATES PTPN11%REACTOME%R-RNO-8865999.1 MET activates PTPN11 Gab1 Hgf Ptpn11 Grb2 RUNX1 AND FOXP3 CONTROL THE DEVELOPMENT OF REGULATORY T LYMPHOCYTES (TREGS)%REACTOME%R-RNO-8877330.1 RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) Cbfb Foxp3 Runx1 BILE ACID AND BILE SALT METABOLISM%REACTOME%R-RNO-194068.1 Bile acid and bile salt metabolism Slco1a1 Nr1h4 Osbp Amacr Akr1d1 Cyp39a1 Slco1a4 Ptgis Slco1a2 Rxra Slco1b2 Fabp6 Acot8 Osbpl3 Slc21a4 Hsd17b4 Osbpl6 Osbpl9 Slc27a5 Osbpl7 Abcb11 Cyp7b1 Hsd3b7 Slco1a6 Acox2 Akr1c2 Ncoa2 Stard5 Ch25h Akr1c12l1 Akr1c3 Slc27a2 Cyp7a1 Baat Cyp46a1 Cyp8b1 Slc10a1 Akr1c19 Akr1c13 Akr1c14 RGD1564865 Slc10a2 Ncoa1 Akr1c12 Akr1c1 PREGNENOLONE BIOSYNTHESIS%REACTOME%R-RNO-196108.1 Pregnenolone biosynthesis Stard3nl Tspo Stard4 Bzrap1 Stard6 Star Akr1b1 Stard3 Fdx1l Fdxr Fdx1 CS DS DEGRADATION%REACTOME DATABASE ID RELEASE 66%10145885 CS DS degradation Vcan Ncan Bcan Hexb Hexa Arsb LOC100910284 Dcn LOC102550316 Hyal1 Cspg5 Cspg4 Idua PI AND PC TRANSPORT BETWEEN ER AND GOLGI MEMBRANES%REACTOME%R-RNO-1483196.1 PI and PC transport between ER and Golgi membranes Pitpnb REELIN SIGNALLING PATHWAY%REACTOME DATABASE ID RELEASE 66%10146225 Reelin signalling pathway Fyn Vldlr Dab1 Sh3kbp1 Reln MRNA EDITING: A TO I CONVERSION%REACTOME%R-RNO-75064.1 mRNA Editing: A to I Conversion Adarb1 Adar PHOSPHOLIPASE C-MEDIATED CASCADE; FGFR2%REACTOME DATABASE ID RELEASE 66%10146098 Phospholipase C-mediated cascade; FGFR2 Fgf16 Fgf17 Fgf10 Fgf9 Fgfr2 Fgf7 Fgf2 Fgf8 Fgf23 Fgf22 Fgf4 Fgf1 Fgf3 Fgf6 Plcg1 Fgf5 Fgf20 MITOCHONDRIAL CALCIUM ION TRANSPORT%REACTOME%R-RNO-8949215.1 Mitochondrial calcium ion transport Pmpcb Pmpca MGC94335 Afg3l2 Micu3 Stoml2 Micu2 Slc8b1 LOC100910779 Micu1 Yme1l1 Spg7 Phb2 LOC100362065 Ccdc109b Mcu MITOCHONDRIAL ABC TRANSPORTERS%REACTOME%R-RNO-1369007.1 Mitochondrial ABC transporters Abcb8 Abcb10 Abcb6 TERMINATION OF TRANSLESION DNA SYNTHESIS%REACTOME DATABASE ID RELEASE 66%10146096 Termination of translesion DNA synthesis Rfc1 Rfc2 Pole2 Pole4 Polh Ns5atp9 Uba7 Poli Usp43 Rev1 Rpa1 Rpa2 Ube2l6 Rpa3 Pole Pold2 Pold1 Pcna Pold4 Isg15 Trim25 Usp10 Rfc5 Rfc4 Rfc3 PEPTIDE HORMONE BIOSYNTHESIS%REACTOME%R-RNO-209952.1 Peptide hormone biosynthesis Lhb Fshb Pomc Inha Inhbc Pcsk1 Tshb Cga Inhba MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS%REACTOME%R-RNO-1362409.1 Mitochondrial iron-sulfur cluster biogenesis LOC100911034 Hscb Iscu Isca2 Isca1 Fdx1l Nfs1 Fdxr Fdx1 Lyrm4 Glrx5 SEROTONIN NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 66%10145528 Serotonin Neurotransmitter Release Cycle Rab3a Rims1 Cplx1 Stx1a Syn3 Syt1 Syn2 Vamp2 Stxbp1 Ppfia1 Ppfia2 Ppfia3 Ppfia4 Bzrap1 Syn1 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATION FROM THE CENTROSOME%REACTOME%R-RNO-380284.1 Loss of proteins required for interphase microtubule organization from the centrosome Dync1i2 Cep57 LOC691918 Haus3 Ninl Akap9 Ccp110 Dync1h1 Pafah1b1 LOC103692716 Dctn1 Cntrl Dctn2 Cep76 Pcm1 Cep78 LOC100911033 Cep164 Dctn3 Cep41 Ofd1 Sdccag8 Tubb5 Prkar2b Cenpj Ywhag Ppp2r1a Plk4 Ywhae LOC100912076 Tubg2 Haus2 Haus1 Haus5 Alms1 Clasp1 Haus4 Odf2 Tubb4a Cdk1 Nek2l1 Ssna1 Mapre1 Tubg1 Cep63 Prkaca Csnk1d Cep131 Tuba4a Cep250 Cep135 Csnk1e Ckap5 Cdk5rap2 Pcnt Nek2 Cep72 Sfi1 Cep70 Actr1a Nedd1 LECTIN PATHWAY OF COMPLEMENT ACTIVATION%REACTOME%R-RNO-166662.1 Lectin pathway of complement activation Masp2 Colec10 Colec11 FORMATION OF THE EARLY ELONGATION COMPLEX%REACTOME DATABASE ID RELEASE 66%10145012 Formation of the Early Elongation Complex Gtf2h1 Gtf2h2 Mnat1 RGD1565904 Ercc3 Polr2g Polr2h Polr2e Polr2f Polr2j Polr2k Polr2d Supt5h LOC100911822 Polr2i Polr2b Polr2c Ercc2 Polr2a Ncbp2 Gtf2f1 LOC100912534 Gtf2f2 Ncbp1 Supt4h1 Cdk7 Nelfe Nelfa Nelfb Ccnh Gtf2h3 Gtf2h5 Gtf2h4 PTK6 PROMOTES HIF1A STABILIZATION%REACTOME%R-RNO-8857538.1 PTK6 promotes HIF1A stabilization Lrrk2 Egfr Hbegf Hif1a Gpnmb Ptk6 METABOLISM OF STEROID HORMONES%REACTOME DATABASE ID RELEASE 66%10145319 Metabolism of steroid hormones Pomc Fdx1 Hsd17b3 Akr1b7 Lhb Akr1b8 Hsd17b1 Hsd17b2 Hsd3b1 Bzrap1 Stard6 Star Hsd3b2 Cyp19a1 Stard3 Fdx1l Cyp11b2 Stard3nl Stard4 Srd5a3 Akr1b1 LOC100911154 Cyp21a1 Fdxr Hsd17b14 Tspo Srd5a1 Srd5a2 Hsd3b Hsd11b2 Cga Hsd17b12 Hsd17b11 CHREBP ACTIVATES METABOLIC GENE EXPRESSION%REACTOME DATABASE ID RELEASE 66%10145124 ChREBP activates metabolic gene expression Acacb Agpat1 Acly Fasn UREA CYCLE%REACTOME DATABASE ID RELEASE 66%10144786 Urea cycle Nmral1 Ass1 Nags Otc Cps1 Slc25a2 Arg1 MRNA EDITING%REACTOME%R-RNO-75072.1 mRNA Editing Apobec1 Apobec2 A1cf Adarb1 Adar Apobec4 BETA OXIDATION OF LAUROYL-COA TO DECANOYL-COA-COA%REACTOME DATABASE ID RELEASE 66%10144931 Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA LOC100911186 Echs1 Hadh Acadl Hadha Hadhb CASP8 ACTIVITY IS INHIBITED%REACTOME%R-RNO-5218900.1 CASP8 activity is inhibited Faslg Traf2 Cflar Fadd Ripk1 Tradd Tnfsf10 Casp8 Fas PTK6 REGULATES CELL CYCLE%REACTOME DATABASE ID RELEASE 66%10146203 PTK6 Regulates Cell Cycle Cdk2 Ccnd1 Cdkn1b Ccne1 Cdk4 Ptk6 HYDROXYCARBOXYLIC ACID-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145664 Hydroxycarboxylic acid-binding receptors Hcar1 Hcar2 EFFECTS OF PIP2 HYDROLYSIS%REACTOME%R-RNO-114508.1 Effects of PIP2 hydrolysis Prkcd Dgkg Dgkd Dgke Dgka Dgkb Prkcq Dgkk Dgki Itpr1 Dgkz Itpr3 Dgkq Dgkh Mgll Trpc3 Abhd12 Trpc7 Daglb Abhd6 Prkch Trpc6 Dagla UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A%REACTOME DATABASE ID RELEASE 66%10144752 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A Psmc6 Psmb10 G6pc Psmb8 Psmb9 Psmb4 Psmb11 Psmb5 Psmf1 Psmb6 Psmd4 Psmb2 Psmd5 Psmd8 Psmb7 Psmd9 Psmb1 Psmb3 Psma8 Psmd11 Psmd12 Psmd13 Psmd14 Psma5 Chek2 Psma2 Psmc5 Psmc3 Psma1 Psmd2 Psma4 Psmc1 Cdc25a Psma3 Psmc4 Psmc2 Psma6 Psme1 Psmd1 Psme2 Psmd7 Psmd3 Psmd6 SYNTHESIS OF PS%REACTOME%R-RNO-1483101.1 Synthesis of PS Ptdss2 PHASE 4 - RESTING MEMBRANE POTENTIAL%REACTOME%R-RNO-5576886.1 Phase 4 - resting membrane potential Kcnj4 Kcnk16 Kcnk5 Kcnk18 Kcnk6 Kcnk7 Kcnj2 Kcnj14 Kcnk1 Kcnk12 Kcnk13 Kcnk2 Kcnk3 LOC100909725 Kcnk4 Kcnj12 Kcnk10 Kcnk9 Kcnk15 NOTCH3 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME DATABASE ID RELEASE 66%10145951 NOTCH3 Activation and Transmission of Signal to the Nucleus Aph1b Psenen Ybx1 Aph1a Dll4 Egfr Jag1 LOC100911293 Notch3 Psen2 Psen1 Ncstn BETA OXIDATION OF BUTANOYL-COA TO ACETYL-COA%REACTOME DATABASE ID RELEASE 66%10144935 Beta oxidation of butanoyl-CoA to acetyl-CoA LOC100911186 Echs1 Hadh Acads UNWINDING OF DNA%REACTOME%R-RNO-176974.1 Unwinding of DNA Gins3 Gins4 Gins1 Gins2 PKB-MEDIATED EVENTS%REACTOME%R-RNO-109703.1 PKB-mediated events Pde3b JOSEPHIN DOMAIN DUBS%REACTOME DATABASE ID RELEASE 66%10146138 Josephin domain DUBs Atxn3 Rad23a Rad23b Josd2 Josd1 Vcp HSP90 CHAPERONE CYCLE FOR SHRS%REACTOME DATABASE ID RELEASE 66%10146010 HSP90 chaperone cycle for SHRs Dnaja2 Dctn1 Dnaja4 Dnajb1 Dctn2 Dync1li2 Hspa1l Hsp90ab1 Fkbp5 Hspa2 Dctn3 Dync1i2 Capzb Actr10 Dync1h1 Dync1li1 Capza2 LOC103692716 Capza3 Ptges3 Stip1 Dynll2 Ptges3l1 Dctn5 Dctn6 Dync1i1 Fkbp4 Dctn4 Pgr Actr1a NEUROFASCIN INTERACTIONS%REACTOME%R-RNO-447043.1 Neurofascin interactions Nfasc Ank1 Nrcam Sdcbp COMPLEX I BIOGENESIS%REACTOME%R-RNO-6799198.1 Complex I biogenesis Ndufab1 Mt-nd4 Ndufa7l Mt-nd5 Ndufaf7 Ndufa7 LOC683884 Ndufaf5 Mt-nd6 Nubpl Mt-nd2 LOC100911483 Ndufb10 Ndufb11 Ndufa12 Ndufa11 Ndufa13 Ndufa10 Ndufb6 Ndufb3 LOC100912599 Ndufb5 LOC100361505 Ndufc2 Ndufb9 Ndufb4 Ndufb8 Ndufb7 Ndufaf3 Ndufaf1 Ndufa2 Ndufa5 Ndufaf4 Ndufa6 RGD1306782 Ndufa1 Ndufs3 Ndufs1 Ndufs4 Ndufs5 Ndufs2 Ndufs8 Ndufs6 Ndufs7 Timmdc1 LOC684509 Acad9 Ndufb2 LOC679739 LOC679195 LOC100910710 LOC680288 Ecsit LOC688963 Tmem126b LOC100363268 Ndufv3 LOC100361144 Ndufv1 Ndufv2 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+%REACTOME%R-RNO-76005.1 Response to elevated platelet cytosolic Ca2+ Stxbp3 Tex264 F13a1 Ola1 Psap Ly6g6f Ctsw Selp Serpina4 Pcyox1l Tor4a Islr Cdc37l1 Chid1 Fam3c Lhfpl2 Nhlrc2 Itih4 Mmrn1 Rarres2 Itih3 Lefty2 Ecm1 Serpine1 Anxa5 Tagln2 Gtpbp2 Timp3 Lefty1 LOC100910414 Lamp2 Plek Sccpdh Phactr2 Cfd Cd9 Kng1l1 A1bg Stx4 Tgfb2 F8 Tgfb1 Tgfb3 Pf4 Aplp2 Cd109 Figf Rab27b Vegfc Vegfb Brpf3 Apoa1 Pdgfa Pdgfb Prkcb Timp1 Abcc4 A2m Tln1 Vwf Actn4 Vegfa Habp4 Pcdh7 Apool Apoh Plg Wdr1 Srgn Prkca LOC100911881 Lgals3bp Sytl4 LOC100912012 Serpina3m Fermt3 Cyb5r1 Maged2 Vcl Sparc Sod1 Actn2 Gas6 Aldoa App Tf Flna Igf2 Igf1 Clu Cd63 Serping1 Fgb RGD1565355 Fgg Hgf Thbs1 Fga Aldoart2 Actn1 Qsox1 LOC685953 Cd36 Scg3 Stxbp2 Kng1 LOC299277 Kng2 Fn1 Ppbp Tuba4a Pros1 Itga2b GLUCONEOGENESIS%REACTOME%R-RNO-70263.1 Gluconeogenesis LOC100911625 Mdh2 G6pc Mdh1 Eno3 Gapdhs Eno1 Tpi1 Eno2 Aldoa Got1 Fbp1 Fbp2 Aldob Gpi Aldoc Slc25a1 Pgk2 G6pc3 Pc Pgk1 Got2 Slc37a2 Pgam1 Pgam2 Pck1 Aldoart2 Slc25a11 Slc37a1 Slc25a10 MAPK6 MAPK4 SIGNALING%REACTOME%R-RNO-5687128.1 MAPK6 MAPK4 signaling Psmc6 Psmb10 Psmb8 Psmb9 Psmb4 Psmb11 Psmb5 Psmf1 Psmb6 Psmd4 Rac1 Psmb2 Psmd5 Psmd8 Psmd9 Psmb3 Psma8 Psmd11 Psmd12 Psmd13 Psmd14 Psmc3 Mapkapk5 Xpo1 Pak2 Pak3 Pak1 Cdc14b Mapk4 Ccnd3 Hspb1 Cdc42ep5 Cdc42ep3 Dnajb1 Etv4 Cdc42ep2 G6pc Mapk6 Psmb7 Psmb1 Kalrn Foxo1 Foxo3 Cdc14a Psma5 Cdk1 Psma2 Cdc42 Prkaca Psmc5 Psmd2 Prkacb Psma1 Psma4 Psmc1 Psma3 Psmc4 Psmc2 Psma6 Psme1 Psmd1 Psme2 Psmd7 Psmd3 Psmd6 SIGNALING BY NUCLEAR RECEPTORS%REACTOME%R-RNO-9006931.1 Signaling by Nuclear Receptors Ppp5c Crabp1 Yy1 Rarg Esr2 RGD1565904 Sdr16c5 Polr2g Polr2h Polr2e Dhrs4 Polr2f Rdh14 Polr2j Rdh13 Polr2k Aldh8a1 Polr2d Fabp5 Polr2i Polr2b Kdm1a Polr2c Polr2a LOC100912534 Cpt1b Rdh10 Rdh16 LOC100365958 Cpt1a Akr1c12l1 Akr1c19 Rara Rarb Akr1c13 Akr1c14 RGD1564865 Akr1c12 Hsp90ab1 Sp1 Cdk9 Hdac1 Jun LOC100911822 Dhrs9 Fos Rxrg Mapk1 Dhrs3 Fkbp5 Med1 Rxra Ppard Atf2 Ppid Ppidl1 Hist1h2bo Cited1 Nr5a2 Hist1h2bcl1 Hist2h3c2 Gtf2f1 Hist1h2bk Gtf2f2 H3f3b Kdm4b Carm1 Akr1c2 Greb1 Usf1 Gtf2a1 Akr1c3 Foxa1 Bmyc LOC103692716 Ptges3 Hdac1l Prmt1 Zfp217 Ptges3l1 Esr1 Pou2f1 Cbfb Tle3 Gata3 Fkbp4 Ddx5 Erbb4 Crebbp Nrip1 Pgr Ncoa1 Tbp Akr1c1 Runx1 LOC100910200 H2afx Hist1h4b LOC684841 Hist1h2bh LOC100912290 Cyp26c1 Hist1h2ail1 Hist1h4m LOC102549173 LOC103690002 LOC100910152 Pdhb LOC100912338 Pdk3 Hist1h3c Pdk4 Pdk1 H2afb3 Hist1h3f Pdk2 LOC100365902 Hist2h4 LOC684819 Pdha2 Hist1h3a Pdha1 H2afj Pdhx Pdha1l1 Hist2h2aa3 Hist1h2bq Hist2h2aa2 LOC100364835 LOC684762 Ncoa2 Dlat Rdh11 Cyp26a1 Hist1h2bg Adh6 LOC680097 LOC684797 LOC100912418 Hist1h2ba Hist3h2bb Cyp26b1 Dld ENOS ACTIVATION%REACTOME DATABASE ID RELEASE 66%10145394 eNOS activation Nos3 Ddah2 Zdhhc21 Ddah1 Spr Cygb LOC103692716 Akt1 GABA RECEPTOR ACTIVATION%REACTOME%R-RNO-977443.1 GABA receptor activation Kcnj4 Kcnj6 Gnai3 Gnal Gnat3 Adcy3 Gabra5 Adcy8 Gabra6 Gabrb1 Adcy9 Gabrg2 Gabra1 Adcy5 Gabra2 Gnai2 Adcy4 Adcy7 Adcy6 Gnb3 Kcnj16 Gnb2 Gnb1 Gng12 Gabrr1 Kcnj2 Kcnj3 Kcnj15 Gabrr3 Gabrr2 Kcnj9 Kcnj5 Gng4 Gngt2 Gnai1 Gng5 Gabbr1 Gngt1 Kcnj12 Gng10 Gabbr2 Gng8 Gabra4 Gng3 Gabrb2 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR%REACTOME DATABASE ID RELEASE 66%10145809 Regulation of gene expression by Hypoxia-inducible Factor Epas1 Hif3a Crebbp Arnt Cited2 Hif1a STEROLS ARE 12-HYDROXYLATED BY CYP8B1%REACTOME%R-RNO-211994.1 Sterols are 12-hydroxylated by CYP8B1 Ptgis Cyp8b1 WNT LIGAND BIOGENESIS AND TRAFFICKING%REACTOME%R-RNO-3238698.1 WNT ligand biogenesis and trafficking Wnt8a Wnt9b Wnt9a Vps26a Wls Wnt5b Wnt8b Wnt5a Wnt3 Wnt7a Wnt1 Wnt2b Wnt11 Wnt7b Wnt4 Vps29 Wnt16 Vps35 Wnt3a Wnt10a Wnt6 MET RECEPTOR ACTIVATION%REACTOME DATABASE ID RELEASE 66%10146172 MET Receptor Activation Hgf Spint2 Hgfac Spint1 GPCR LIGAND BINDING%REACTOME DATABASE ID RELEASE 66%10145122 GPCR ligand binding Gpr39 Ffar1 Ptgir Kng1l1 Cmklr1 Gpr35 Ccr6 Pomc Chrm4 Oxtr Oxt LOC100909648 Avpr1b Avpr1a Opn1sw Oprl1 Tas2r144 Grm3 Ccl21 Casr Prokr2 Mc3r Grm1 Ccr5 Grm6 Gal Tas2r113 Ccr4 Grm2 Ccr3 Grm8 Gpr37 Ccl27 Tas2r114 Cckar Tas2r110 Gper1 Ccl20 Uts2r Prokr1 Ccl25 Gprc6a NMS Xcr1 Tas2r124 Cxcl16 Tas2r125 Pdyn Tas2r126 Prlhr Tas2r121 Ccr10 Tas2r103 Gpr37l1 Tas2r104 Tas2r123 Ccl19 Ccr7 Tas2r116 Ccr8 Tas2r140 Tas2r120 Cxcr3 Cxcl10 Tas2r102 Ccr9 Opn1mw Tas2r145 Cxcl11 Tas2r119 Ece2 Tas2r118 Ece1 Tas2r117 Xk Ghrh Ramp3 Sstr5 Vipr2 Brs3 Tas2r107 Npbwr1 Sct Tas2r108 C5ar2 Pyy Gip Tas2r105 Pnoc Gipr Tas2r106 Ccl5 Tas2r129 Pth1r Npy2r Iapp Tas2r109 Mc4r Crhr2 Tas2r136 Prok2 Gcgr Tas2r137 Tas1r1 Adgre1 Oprm1 Prok1 Crhr1 Tas2r135 Mchr1 Sstr1 Glp2r Tas2r13 Tas2r130 Pth2 Aplnr Ramp2 Sstr4 Tas1r3 Sstr2 Tas2r139 Ghrhr Cck Npy1r Apln Tacr3 Tacr2 Bdkrb1 Bdkrb2 Rln3 Npb Ppy Trh Ccl1 Npw Mc2r Gng10 Npy Nps Adra1a Tbxa2r Sstr3 Penk Adra1d C5ar1 Kng1 Kng2 Gphb5 Gnrhr Gpha2 Gnrh1 Fshr Htr4 Tshr Cxcr5 Htr7 Uts2b Npy5r Nmur2 Cxcr6 Oprd1 Lhcgr LOC100909513 LOC100360745 Htr6 Npff Npffr2 RGD1560028 Hcrt Psap Npffr1 Qrfp LOC100909783 Lhb Oxgr1 Ptgdr Ptgdr2 Sucnr1 Adra2b Adrb3 Hcrtr1 F2rl3 F2r Qrfpr F2 Cxcr2 Hcrtr2 Ptger2 Tshb Cga F2rl2 Hebp1 Uts2 Pth Fpr-rs6 Ntsr2 Sctr Trhr Adm Crhbp Nmu Fpr-rs3 Pf4 Calcb Mc5r Fpr2 Vip Ntsr1 Fpr3 Pmch Anxa1 Calca Ramp1 Rxfp1 Htr2c Adcyap1r1 Rxfp2 Htr2a Ucn Kel Fpr-rs4 Adcyap1 Insl3 Tac3 Ucn2 Kiss1 Pth2r Adm2 Rxfp3 Crh Tac1 Htr2b Lpar5 Edn2 S1pr1 Ednra S1pr5 Ednrb Ptafr S1pr4 Grp Edn3 S1pr3 Grpr Cx3cr1 Lpar1 Edn1 Lpar3 F2rl1 Lpar2 Sst Ackr4 S1pr2 Ackr3 Nmb Xcl1 Cxcl9 Cxcl6 Cx3cl1 Gpr31 Cxcl2 Rgr Cxcl1 Taar9 Gpr18 Gpr55 Gpr4 Hrh2 Fshb Htr5a Cxcl3 Taar6 Agt Gpr132 Gnb3 Cnr2 Taar5 Gpr143 Gnb5 Taar2 Opn3 Lppr1 Opn4 Gnb2 Cnr1 Htr1d Lppr4 Gnb1 Gng13 Htr1f Lppr5 Gng12 Htr1a Lppr2 Gng11 Htr1b Hrh1 Lppr3 Chrm1 Hrh4 Chrm5 Ptger3 Adora3 Gpr183 Agtr2 Mtnr1a Prlh Opn5 Galr1 LOC100909523 Ccrl2 LOC100912034 Nts Hcar1 Gnb4 Oprk1 Hcar2 Adora2a Cysltr2 Glp1r Gcg Adora2b Cysltr1 Drd5 Gpr65 Drd1 Gng4 Gpr68 Gngt2 LOC100911796 Drd4 Ptgfr Gng5 LOC100363178 Drd2 Gngt1 Adora1 Ptger1 Gng8 Chrm3 LOC100365814 Gng3 Agtr1b Agtr1a Fpr1 Chrm2 Ltb4r Ffar2 Ffar3 Ltb4r2 Avp Gabbr1 Gabbr2 C3ar1 P2ry6 Lpar6 P2ry4 P2ry1 Gpr17 Lpar4 Ptgdrl Cxcl12 P2ry12 Cxcr4 P2ry2 P2ry10 P2ry13 Adra2a Adra2c C3 Cckbr Ppbp Adrb2 Tacr1 TRIGLYCERIDE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 66%10144910 Triglyceride biosynthesis Gpam Mogat1 Lpin2 Gk Mogat2 Lpin3 Lpin1 Dgat2 Gk2 Dgat1 Gpat2 Agmo BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME%R-RNO-70895.1 Branched-chain amino acid catabolism Mccc2 Bckdhb Bckdk Bcat1 Hsd17b10 Bcat2 Mccc1 Acat1 Shmt1 Dbt Hibadh Auh Aldh6a1 Ivd Acadsb Hibch Tmlhe Dld Ppm1k NTRK2 ACTIVATES RAC1%REACTOME DATABASE ID RELEASE 66%10146322 NTRK2 activates RAC1 Gab1 Hgf Crk Crkl Dock7 Rac1 Grb2 LOC100911248 SIGNALING BY ERBB4%REACTOME%R-RNO-1236394.1 Signaling by ERBB4 Stat5a Ereg Nrg1 Src Kras Btc Aph1b Erbb3 Pik3r1 Psenen Aph1a Nrg3 LOC100911293 Egfr Psen2 Hbegf Psen1 Ncstn Nrg4 Wwp1 Esr1 Yap1 Hras Erbb4 Nras Sos1 Shc1 Nrg2 Grb2 DNA DAMAGE REVERSAL%REACTOME DATABASE ID RELEASE 66%10146231 DNA Damage Reversal Fto Alkbh5 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX%REACTOME%R-RNO-3769402.1 Deactivation of the beta-catenin transactivating complex Apc Akt1 Men1 Hdac1 Chd8 Ywhaz Xiap Ash2l Sox2 Sox7 Sox6 Sry Sox17 Ctnnbip1 Hdac1l Btrc Cby1 Sox13 Pygo2 Xpo1 Tle3 Tcf7 Lef1 Tcf7l1 Bcl9l Tle4 Sox9 Tle1 Tle2 Akt2 Pygo1 Rbbp5 RECRUITMENT AND ATM-MEDIATED PHOSPHORYLATION OF REPAIR AND SIGNALING PROTEINS AT DNA DOUBLE STRAND BREAKS%REACTOME DATABASE ID RELEASE 66%10144760 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Bard1 Ppp5c Bre Rad50 Brcc3 Pias4 Uimc1 Atm Hist1h2bo Hist1h2bcl1 Hist1h2bk LOC100909750 Kdm4b Kdm4a Sumo1 Brca1 Bap1 Mdc1 Ube2v2 Ube2n Ube2i Smarca5 Nbn Abl1 Mre11a LOC100910200 Whsc1 H2afx Hist1h4b Rnf8 Hist1h2bh LOC100912290 Eya3 Apbb1 Babam1 LOC686349 Tp53bp1 Eya2 Hist1h4m Eya4 LOC100912338 Herc2 Hist2h4 Hist1h2bq LOC100364835 Baz1b Mapk8 Fam175a LOC100910954 Chek2 Hist1h2bg LOC680097 LOC684797 LOC100912418 Hist1h2ba Hist3h2bb TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE%REACTOME%R-RNO-168179.1 Toll Like Receptor TLR1:TLR2 Cascade Map2k7 Ripk2 Map2k6 Ager Dusp3 Map2k4 Map3k8 Dusp4 Peli3 Nfkbib LOC100912399 Peli2 Map3k1 Traf6 Cul1 Vrk3 Rps6ka2 Rps6ka1 App Rps6ka3 Rps6ka5 Tirap LOC100912585 Tab1 Dusp7 Dusp6 Rela Atf1 Atf2 Map3k7 Peli1 Irak2 Nfkbia LOC100910771 Ube2n Jun Ppp2cb Ppp2ca Skp1 Ppp2r1a Nfkb2 Nfkb1 Mapk9 Mapk8 Fos S100b Mapk7 Dhx9 Fbxw11 Chuk Ppp2r1b Ecsit Mapkapk3 Btrc Mapkapk2 Mapk1 Nkiras1 LOC100362142 Nod1 Nod2 Nkiras2 Creb1 Tab2 Tab3 LOC100912618 Ube2v1 Ikbkb Mapk14 Myd88 Tnip2 Mapk11 Mapk10 HEDGEHOG 'OFF' STATE%REACTOME%R-RNO-5610787.1 Hedgehog 'off' state Psmc6 Psmb10 Psmb8 Psmb9 Psmb4 Psmb11 Psmb5 Psmf1 Psmb6 Psmd4 Psmb2 Rbx1 Cul1 Psmd5 Psmd8 Psmd9 Psmb3 Psma8 Psmd11 Psmd12 Psmd13 Psmd14 Adcy8 Rpgrip1l Adcy9 Adcy5 Adcy4 Adcy7 Adcy6 Prkar1b Prkar1a Smo Wdr35 Kif3a Ift88 Psmc3 Mks1 Csnk1a1 Sufu G6pc Ptch1 Ofd1 Psmb7 Psmb1 Gli1 Gli3 Gli2 Adcy3 Prkar2b Skp1 Prkar2a Ift122 Wdr19 Ttc21b Psma5 Btrc Psma2 Prkaca Psmc5 Ift52 Psmd2 Prkacb Psma1 Kif7 Psma4 Psmc1 Ift57 Psma3 Psmc4 Psmc2 Psma6 Psme1 Psmd1 Psme2 Psmd7 Gpr161 Ift140 Psmd3 Tulp3 Psmd6 APC-CDC20 MEDIATED DEGRADATION OF NEK2A%REACTOME DATABASE ID RELEASE 66%10145263 APC-Cdc20 mediated degradation of Nek2A Anapc7 Cdc26 Cdc27 Cdc23 Ube2c Ube2d1 Bub3 Anapc16 Cdc16 Cdc20 Nek2l1 Anapc4 Anapc2 Anapc1 Bub1b Anapc11 Anapc15 Nek2 Mad2l1 Anapc10 NFG AND PRONGF BINDS TO P75NTR%REACTOME%R-RNO-205017.1 NFG and proNGF binds to p75NTR Ngf Ngfr TRANSCRIPTIONAL ACTIVATION OF CELL CYCLE INHIBITOR P21%REACTOME DATABASE ID RELEASE 66%10146177 Transcriptional activation of cell cycle inhibitor p21 Zfp385a LOC100910954 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS%REACTOME%R-RNO-416993.1 Trafficking of GluR2-containing AMPA receptors Ap2a2 Prkca Prkcb Nsf Ap2s1 Gria3 Gria4 Grip1 Grip2 Ap2a1 Pick1 Ap2m1 PROLINE CATABOLISM%REACTOME DATABASE ID RELEASE 66%10144794 Proline catabolism Prodh Iffo2 Tas1r2 Aldh4a1 DEGRADATION OF GLI1 BY THE PROTEASOME%REACTOME DATABASE ID RELEASE 66%10146077 Degradation of GLI1 by the proteasome Psmc6 Psmb10 Sufu G6pc Psmb8 Psmb9 Psmb4 Psmb11 Psmb5 Psmf1 Psmb6 Psmd4 Psmb2 Rbx1 Cul1 Psmd5 Psmd8 Psmb7 Psmd9 Psmb1 Gli1 Psmb3 Psma8 Skp1 Psmd11 Psmd12 Psmd13 Psmd14 Psma5 Btrc Psma2 Psmc5 Psmc3 Psmd2 Psma1 Psma4 Psmc1 Psma3 Psmc4 Psmc2 Psma6 Psme1 Psmd1 Psme2 Psmd7 Psmd3 Psmd6 BETA OXIDATION OF DECANOYL-COA TO OCTANOYL-COA-COA%REACTOME%R-RNO-77346.1 Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA LOC100911186 Echs1 Hadh Hadha Hadhb Acadm MMR%REACTOME%R-RNO-5358508.1 MMR Msh3 Msh2 Rpa3 LOC100911727 Pold2 Pold1 Pcna Pold4 Rpa1 Rpa2 Pms2 Mlh1 Msh6 Lig1 POST-TRANSCRIPTIONAL SILENCING BY SMALL RNAS%REACTOME DATABASE ID RELEASE 66%10145622 Post-transcriptional silencing by small RNAs Ago3 Ago4 Tnrc6b Ago2 Tnrc6a Tnrc6c PI METABOLISM%REACTOME DATABASE ID RELEASE 66%10145378 PI Metabolism Enpp6 Pten Tpte2 Pitpnb Sbf1 Ptpn13 Inpp4a Inpp4b Mtmr14 Mtmr12 Sacm1l Pip5k1c Pi4k2a Pip5k1b Pip5k1a Fig4 Vac14 Tmem55b Pip4k2b Ocrl Pip4k2c Pik3r5 Bmx Mtmr9 Mtmr6 Pik3r1 Pik3r3 Mtmr7 Pik3r2 Mtmr2 Pik3r6 Synj1 Pi4kb Mtmr4 Plekha4 Plekha3 Plekha5 Inpp5d Inpp5e Plekha8 Synj2 Plekha1 Inpp5f Tnfaip8l3 Pik3cd Tnfaip8l1 Mtmr3 Pik3cg Mtmr1 Inpp5j Tnfaip8 Tnfaip8l2 Rufy1 Pik3c3 Pik3r4 Pik3cb Pnpla6 Pikfyve Pik3c2a Pik3c2b Pik3c2g Pi4k2b NEGATIVE REGULATION OF FGFR4 SIGNALING%REACTOME%R-RNO-5654733.1 Negative regulation of FGFR4 signaling Mknk1 Src Fgf16 Fgf17 Fgf9 Fgf2 Fgf8 Cbl Spry2 Fgfr4 Mapk1 Fgf23 Fgf4 Ptpn11 Fgf1 Ppp2cb Ppp2ca Fgf6 Ppp2r1a Fgf19 Frs2 Fgf20 Grb2 NUCLEOBASE CATABOLISM%REACTOME%R-RNO-8956319.1 Nucleobase catabolism Nt5c1a Nt5c Adprm Nt5c3a Nudt9 Nt5e Nt5c2 Nudt5 Nudt16 Nudt18 Upb1 Nt5m LOC688828 Entpd2 Tymp Entpd6 Entpd3 Entpd4 Entpd1 Entpd7 Entpd5 Entpd8 Xdh Dpys Pnp Upp1 Upp2 Nt5c1b Nudt15 Nudt1 Gda Itpa Samhd1 Dnph1 CROSS-PRESENTATION OF PARTICULATE EXOGENOUS ANTIGENS (PHAGOSOMES)%REACTOME%R-RNO-1236973.1 Cross-presentation of particulate exogenous antigens (phagosomes) LOC685953 Cd36 Ncf1 Ncf4 RGD1565355 Cybb Cyba MEIOSIS%REACTOME%R-RNO-1500620.1 Meiosis Prdm9 AKT-MEDIATED INACTIVATION OF FOXO1A%REACTOME DATABASE ID RELEASE 66%10145436 AKT-mediated inactivation of FOXO1A Akt3 Foxo1 Akt1 Akt2 CREB PHOSPHORYLATION%REACTOME%R-RNO-199920.1 CREB phosphorylation Rps6ka2 Rps6ka1 Rps6ka3 Rps6ka5 Creb1 Atf1 Mapkapk2 RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN INTERLEUKIN SIGNALING%REACTOME DATABASE ID RELEASE 66%10146268 RUNX1 regulates transcription of genes involved in interleukin signaling Elf1 Cbfb Runx1 SDK INTERACTIONS%REACTOME%R-RNO-373756.1 SDK interactions Sdk2 XENOBIOTICS%REACTOME DATABASE ID RELEASE 66%10144919 Xenobiotics Cyp2b2 Cyp2c24 Cyp2s1 Cyp2b1 Cyp2b3 Cyp2d5 LOC100361492 Cyp2j10 LOC100360055 Ahr LOC100910127 Cyp2c13 LOC100361547 Cyp3a23/3a1 Cyp3a73 Cyp2b21 Arnt LOC100911763 Cyp2c7 Cyp2b15 Cyp2e1 Cyp2b12 Cyp2d4 Cyp2f4 Cyp3a18 Cyp1a1 LOC100910877 Cyp2d2 Arnt2 Cyp1a2 Cyp2d3 Cyp2c6v1 SIGNALING PATHWAYS%REACTOME%R-RNO-162582.1 Signaling Pathways Usp7 Yy1 Rbx1 RGD1565904 Polr2g Polr2h Polr2e Polr2f Polr2j Polr2k Polr2d Polr2i Polr2b Polr2c Polr2a LOC100912534 Actb Cdk4 Ccnd1 LOC100911822 Irak4 Ripk2 Dusp3 Dusp4 Traf6 Cul1 Vrk3 Rps6ka2 Rps6ka1 App Rps6ka3 Rps6ka5 LOC100912585 Tab1 Dusp7 Dusp6 Rela Atf1 Atf2 Map3k7 Nfkbia LOC100910771 Parp1 Cdk2 Rbbp5 Hnrnph1 Jun Ppp2cb Ppp2ca Skp1 Ppp2r1a Ncbp2 Nfkb1 Mapk8 Fos Ncbp1 Mapk7 Ybx1 Chuk Ppp2r1b Mapkapk3 Btrc Mapkapk2 Mapk1 Adora3 Creb1 Tab2 Tab3 Adora2a Adora2b Ikbkb Hnrnpm Hnrnpf Mapk14 Myd88 LOC100911796 LOC100363178 Adora1 Mapk11 LOC100365814 Smarca4 Mecom Ash2l Gpr39 Olr663 Olr660 Olr561 Olr1024 Olr560 LOC100910009 Olr158 Olr557 LOC100910335 Olr164 Olr659 Olr160 Olr657 Olr662 Olr664 Olr1868 Olr1199 Gpr27 Olr653 LOC100910402 Olr651 Olr650 Olr294 LOC100911909 Olr544 Olr1197 Olr1196 Olr1195 Olr1194 Olr1198 LOC100910409 Olr1128 LOC100911893 LOC100910928 Olr323 Olr119 Olr1126 LOC100912097 Olr1125 Olr420 Olr217 Olr1121 Olr1122 Olr1129 Olr322 Olr214 Olr215 Olr414 Kng1l1 Olr1512 Olr1513 Olr416 Olr556 Gpr150 Olr1511 Olr413 Olr1517 Olr319 Olr120 Olr321 Olr1514 LOC100911380 Olr417 Olr418 LOC100910041 Olr259 Olr1163 Tmed2 Olr1166 LOC684208 Olr127 Olr530 Olr126 Olr931 Olr674 Olr129 Olr532 Olr1174 Olr670 Gpr45 Olr675 Olr892 Olr247 Olr1156 Olr190 Olr194 Olr267 LOC500460 Olr192 Olr262 Olr1064 Olr896 Olr263 LOC100910049 Olr698 Olr799 LOC103693566 Olr922 Olr684 Olr1186 LOC100910120 Olr536 Olr1185 Tln1 Olr143 Crk Olr535 Olr140 Vwf Apbb1ip Olr142 Bcar1 Olr148 LOC100910648 Olr1016 Olr149 Olr951 Gpr25 LOC100910224 Olr666 Traf2 Olr1179 Olr522 Olr130 Olr527 Olr526 LOC100910637 Olr132 LOC100910010 Olr529 Olr528 Olr139 Olr137 Olr686 Olr1877 LOC100910559 Olr186 Olr189 Olr1081 Usp21 Olr1147 Olr188 Olr584 Olr1082 Olr281 Olr382 Olr384 Olr1086 Olr1087 Olr587 Olr581 Olr282 Olr776 Olr582 Olr777 Olr583 Olr283 Il33 Olr962 Gpr15 Olr964 Olr285 Olr286 Olr1135 Olr1132 Olr172 LOC100910051 Olr1130 Olr170 Olr198 Olr588 Olr199 Olr1155 Olr597 Olr1057 Olr196 LOC100911805 Grk6 Olr252 Olr1052 Olr598 Olr695 Olr251 Olr250 Olr697 LOC100910999 Olr590 Grk5 LOC100910445 Olr1143 Olr180 Olr690 Olr1144 Olr783 Olr379 Olr1142 LOC100910162 Olr782 Gpr176 LOC100911839 Olr184 Olr845 LOC100910274 Olr847 Olr848 Olr1391 Gpihbp1 Olr852 Olr1496 LOC686792 LOC100912204 Olr1096 LOC100365798 RGD1562066 Olr844 Olr841 Olr744 Olr745 LOC100909686 Olr878 LOC100910597 Olr1376 Penk Olr850 Olr851 LOC100909578 LOC100909683 LOC100910294 Kng1 LOC687097 LOC100909884 LOC100909885 Foxo4 Olr1374 Olr1372 Olr1373 Olr1370 Kng2 Olr1071 Olr569 Olr174 Olr175 Olr774 Olr176 Htr4 Olr1274 Olr1076 LOC100910876 Olr575 Olr1075 Olr373 Olr1275 Olr1070 Olr1137 Htr7 Olr375 Olr377 Olr378 Olr372 Olr1079 Olr374 Olr1073 Olr854 Olr853 Olr279 LOC100911035 Olr765 Olr278 Olr376 Htr6 Npff LOC100910256 LOC100912571 Npffr2 Olr834 Olr641 LOC100909438 RGD1560028 LOC100909796 Hcrt Npffr1 Gpr83 Eif4ebp1 Qrfp LOC690821 LOC100909783 LOC100912217 Olr601 Olr602 Olr604 Olr709 Olr609 Olr607 Olr608 LOC687088 Olfr873 Olr806 LOC686677 Olr702 Olr808 Olr705 Olr704 Olr807 Olr519 Olr614 Olr718 Eif4g1 Olr811 Olr514 Olr515 Olr611 Olr610 Rictor Olr819 Olr716 Olr713 Olr816 Olr717 Olr714 Olr813 Olr812 Olr1382 Olr1381 Olr1384 Olr1383 Olr711 LOC100911372 Hif1a LOC100912327 Olr818 Olr712 Olr724 Olr1380 Reep6 LOC684683 Rps6 Olr720 Olr722 LOC686660 Olr1385 Olr1378 Hcrtr1 Reep1 Qrfpr Reep5 Olr729 Hcrtr2 Reep4 Reep3 LOC680559 Reep2 Olr725 Src Wnt5b Wnt5a Prickle1 Fzd1 Cltc Cltb Fzd3 Clta Fzd2 Fzd4 Ywhah Fzd7 Ywhag Fzd6 Sfn Prkcb Ywhaz Ap2s1 Wnt1 Ppp3r1 Otulin Wnt11 Wnt4 Ywhab Ap2a1 Ywhaq Ror1 Ywhae Ror2 Ap2m1 Bad Smpd2 Smpd3 Usp4 LOC687065 Drd5 Drd1 LOC684539 Olr820 Olr821 Olr823 Med1 Mgll Abhd12 Daglb Abhd6 Dagla Cited1 Nr5a2 Gtf2f1 Gtf2f2 Kdm4b Carm1 Greb1 Usf1 Gtf2a1 Foxa1 Bmyc Thbs2 Ptges3 Prmt1 Zfp217 Ptges3l1 Esr1 Pou2f1 Cbfb Tle3 Gata3 Fkbp4 Ddx5 Erbb4 Crebbp Nrip1 Pgr Ncoa1 Tbp Runx1 Kras Grb7 Pik3r1 Il6 Pik3r2 Dll4 LOC100911431 Eif4b Usp2 Adra2a Gnai2 Adra2c Cdk1 Mapkap1 Pik3cb Tek Ptpn11 Notch2 Mdk Angpt1 Hras Nras Gnai1 Sos1 Shc1 Grb2 Ptpn18 Ereg Rnf41 Nrg1 Btc LOC102552659 Erbb3 Erbb2 Nrg3 Matk Egfr Jag1 Hbegf Notch3 Ghrl Nrg4 Tnf Rnf31 Atp6v1g1 Sharpin Atp6v1g2 Traf1 Atp6v0a4 Rbck1 Atp6v1b2 Atp6v0a2 Atp6v1h Atp6v1f Il1rap Ptpn12 Usp8 Nrg2 Pnlip Pik3ap1 Il1rl1 F11r Atp6v0d1 Atp6v1c2 Atp6v0d2 Phlpp1 Ier3 Pdgfa Pdgfb Rps6kb2 Foxo1 Foxo3 Atp6v1a Atp6v0e2 Atp6v0e1 Clps Cma1 Atp6v1g3 Atp6v1e1 Atp6v1e2 Cdh1 Atp6v1c1 A2m Kdr Itga3 Abca4 Lama4 Plg Prkca Lyn Crkl Yes1 Lama1 Rapgef1 Galnt3 Syk LOC100911248 Oprl1 Grin2d Ccl21 Camk2g Prokr2 Grin2b Grin1 Mc3r Ccr5 Gal Ccr4 Nefl Rasgrf1 Mmp9 Ccr3 Gpr37 Dlg1 Ccl27 Dlg2 Cckar Frs3 Gper1 Ccl20 Dlg3 Uts2r Camk2d Prokr1 Actn2 Ccl25 Camk2a NMS Xcr1 Cxcl16 Pdyn Lamc1 Prlhr Lamc2 Ccr10 Gpr37l1 Ccl19 Ccr7 Ccr8 Cxcr3 Cxcl10 Ccr9 Cxcl11 Ece2 Ece1 Xk Sstr5 Brs3 Npbwr1 Pyy Col9a1 Pnoc Col9a2 Ccl5 Npy2r Col9a3 Prkcq Mc4r Col4a1 Prok2 Oprm1 Fgb Prok1 Ret Sstr1 Fgg Mchr1 Aplnr Sstr4 Sstr2 Cck Npy1r Thbs1 Apln Tacr3 Col4a2 Fes Tacr2 Bdkrb1 Fga Gdnf Bdkrb2 Rln3 Lamb1 Npb Ppy Trh Ccl1 Lamb2 Npw Map2k2 Lamb3 Mc2r Pspn Npy Nps Spp1 Pde3a Sstr3 Spta1 Gfra4 Gfra3 Gfra2 Dok1 Pde2a Cyct Pde10a Pde11a Gphb5 Artn Fn1 Gnrhr Gpha2 Shc3 P4hb Gnrh1 Nrtn Ptpra Fshr Tshr Lrrk2 Ncam1 Sptbn1 Khdrbs2 Gpnmb Khdrbs1 Khdrbs3 Cxcr5 Uts2b Npy5r Nmur2 Cxcr6 Oprd1 Itga2b Lhcgr LOC100909513 LOC100360745 Pten Adam17 Aph1b Psenen Aph1a Ngfr LOC100911293 Psen2 Psen1 Ncstn Lhb Furin Awat2 Cpt1b Cpt1a Fgf2 Ttr Bmp2 Tgfb1 RGD1564865 Cga Pik3r5 Uts2 Ntsr2 Trhr Nmu Pf4 Mc5r Pik3r3 Ntsr1 Pmch Pik3r6 Rxfp1 Rxfp2 Kel Insl3 Tac3 Kiss1 Rxfp3 Tac1 Edn2 Ednra Ednrb Edn3 Grpr Cx3cr1 Edn1 F2rl1 Sst Ackr4 Ackr3 Nmb Xcl1 Cxcl9 Cxcl6 Cx3cl1 Agtr2 Prlh Galr1 Ccrl2 Nts Oprk1 Cd80 Cd86 Pla2g4a Gabbr1 Gabbr2 Il6st Cyp26c1 Cxcl12 Myo9b Cxcr4 Arhgdia Rtn4 Cyp26a1 Adh6 Lingo1 Omg Mag Cyp4v3 Cyp26b1 Csnk2a2 Csnk2a1 Stra6 Rdh10 Wnt9b Rdh16 Wnt9a LOC100365958 Vps26a Wls LOC100362350 Akr1c12l1 Cmklr1 Gpr35 Akr1c19 Wnt7a Wnt2b Wnt7b Akr1c13 Vps29 Akr1c14 Wnt16 Vps35 Akr1c12 Wnt10a Wnt6 Pomc Tax1bp1 Sppl2a Clip3 Rpe65 Pik3cd Dhrs9 Nup85 Pik3cg Myo7a Sdr9c7 Hsd17b6 Gpc6 Gpc4 Gpc2 Gpc1 Opn1sw Dhrs3 Rlbp1 Nup98 Nup107 Akr1b7 Akr1b8 Ppard Opn1mw Pip5k1c Pip5k1b Pip5k1a Akr1c2 Akr1c3 Ocrl Akr1c1 Cdc14b Agrn Mapk4 Cdc42ep5 Cdc42ep3 Etv4 Cdc42ep2 G6pc Mapk6 Atp6ap1 Nup43 Nup133 Nup37 Sdc2 Sdc3 Sdc4 Adra2b Adrb3 Ranbp2 Lpar5 S1pr1 S1pr5 S1pr4 S1pr3 Lpar1 Lpar3 Lpar2 S1pr2 Lppr1 Lppr4 Lppr5 Lppr2 Lppr3 Ctbp2 Sav1 Amot Ptpru Cab39l Grap Fer Stk4 Stk3 Mob1b Mob1a Wwc1 Eef2k Elf3 Lats1 Strada Stradb Amotl2 Rps6kb1 Fstl1 Grem2 Fstl3 Amhr2 Cer1 Nog Foxh1 Acvrl1 Amh Acvr2a Chrdl1 Smad9 Smad5 Smad6 Acvr1c Gdf2 Bmpr2 Acvr1b Fst Zfyve16 Inhba Drap1 Birc3 Birc2 Cyld Notch4 Casp2 Casp8 Casp9 Cckbr Gast Ngfrap1 Plcb1 Racgap1 Plcb3 Ffar1 Rarg Gnaq Esr2 Gna11 Gna14 Gna15 Nr4a1 Inpp5b Plcb4 Lrp5 Lrp6 Wnt3 Rnf43 Mapkapk5 Rara Rarb Yap1 Rspo1 Lgr4 Lgr6 Lgr5 Rspo4 Wnt3a Rspo2 Rspo3 Gnai3 Dock7 Akt1 Ranbp9 Ntf4 Gnao1 Ntrk2 Bdnf Chrm4 Gnat2 Gnaz Rxrg Ntrk3 Ntf3 Rhob Dlg4 Rhoc Dtx4 Prc1 Cit Cyfip1 Arf6 Spint1 Gga3 Gdi2 Hgf Ptpn2 Stam2 Sh3gl2 Sh3gl1 Spint2 Sh3kbp1 Muc20 Hgfac Nckap1l Sh3gl3 Ranbp10 Tns4 Lrig1 Stam Rab4a Rock1 Frk Psmb7 Psmb1 Lrrc7 C5ar1 LOC687609 Dsn1 Cab39 Atp6v0a1 Psma5 Rap1a Psma2 Psmd2 Ptpn6 Psmc2 Psmd1 Psmd7 Iqgap1 Psmd3 Psmd6 Ptpn1 Tshb Dnajb1 Gnal Akt1s1 Gnat3 Prkci Grp Ffar4 Xiap Tnks Phc1 Phc2 Stat5a Jak3 Stat1 Jak1 Madd Stat3 Rxra Hist1h2bo Sall4 Hist1h2bcl1 Scmh1 Hist2h3c2 Cbx4 Hist1h2bk Cbx2 H3f3b Cbx8 Cbx6 Bmi1 Hdac2 Rnf2 Mbd3 Usp13 Ring1 Chd3 Chd4 Phc3 Prex2 Mta3 Tnks2 Mta1 Mta2 Tyk2 Gatad2a LOC100910717 Maf1 Gatad2b Eed LOC100910200 H2afx Hist1h4b LOC684841 Hist1h2bh LOC100912290 Rbbp7 Hist1h2ail1 Hist1h4m LOC102549173 LOC103690002 LOC100910152 LOC100912338 Hist1h3c H2afb3 Hist1h3f Hist2h4 LOC684819 Hist1h3a H2afj Hist2h2aa3 Hist1h2bq Hist2h2aa2 LOC100364835 LOC684762 Lrp1 RGD1560225 Ppp3ca Tec Lat Plcg1 Hist1h2bg Ezh2 LOC680097 LOC684797 LOC100912418 Hist1h2ba Hist3h2bb Cnga1 Gucy2f Pde6b Rcvrn Gucy2d Pde6a Rgs9 RGD1560341 Gpr84 Guca1b Ppef1 Metap2 Metap1 Gnat1 Nmt1 Guca1a Cngb1 Rgs9bp Fnta Nmt2 Sag Grk4 Grk1 Fntb Pde6g Cdc14a Cdkn1a Cdkn1b Vegfa Rasa1 Shb Fkbp5 Pdhb Pdk3 Pdk4 Pdk1 Pdk2 LOC100365902 Pdha2 Pdha1 Pdhx Pdha1l1 Dlat Dld Atp6v1d Psap Rac1 Psmd11 Psmd12 Fabp5 Oxgr1 Psmd13 Psmd14 Ccr1 Ccr1l1 Ptgdr2 Sucnr1 Ap2a2 Psmc3 Diaph1 Cxcr2 Atp6v0c Hsp90ab1 Ptafr Rab4b Gpr31 Cxcl2 Cxcl1 Rgr Gpr18 Bag4 Gpr55 Gpsm3 Htr5a Cxcl3 Gpsm2 Gpsm1 Cnr2 Ccl4 Opn3 Cnr1 Htr1d Htr1f Htr1a Htr1b Hrh4 Ptger3 Gpr183 Mtnr1a Opn5 Pcp2 Hcar1 Hcar2 Sh2b2 Drd4 Drd2 Fpr1 Apc Otud3 Otud7b Vcl Sptan1 Vcp Dkk1 Kremen2 Sost Chd8 Ripk1 Lamtor3 Tnfaip3 Dync1h1 Lamtor2 Lamtor1 Dync1li1 LOC103692716 Cybb Cyba Hmha1 C3ar1 Prkcd Notch1 Peg12 Amer1 Dtx2 Frat2 Tcirg1 Ptprj Jup Cd28 Icos Bcl2l11 Tjp2 Dtx1 Sox2 Hecw1 Dact1 Csnk2b Actr2 Wnt8a Sox7 Sox6 Sry Sox17 Rbp4 Arhgap9 Ctnnbip1 Ryk Wnt8b C3 Lrp10 Dkk2 Dkk4 Rbp2 Cby1 Ppbp Tex12 Sox13 Rbp1 Lrp8 Apom Lrp12 Lpl Rhoa Bco1 Rdh11 Arpc5 Lrat Pcsk6 Bco2 Rhof Rhog Pcsk5 Olr1442 Olr1443 Nsmaf Trim27 Olr1548 Olr80 Mdm2 Olr1440 Olr1547 Ppp1ca Pde4a Crabp1 Pde4d Pde4c Ppp1r1b Cdk5 Sdr16c5 Socs3 Nos3 Leo1 Dhrs4 Rdh14 Rdh13 Aldh8a1 Epor Pml Epo Olr1436 Ptgir Olr1569 Olr1567 Olr1421 Fyn Olr1568 Olr1565 Stat6 Olr1566 Olr1538 LOC100912374 Olr1539 Olr1437 Olr1439 Olr1433 Olr1434 Olr1435 LOC103690304 Olr83 LOC100912370 Olr1533 Olr1432 Olr1535 Olr1537 Olr1536 Olr81 Olr1449 Olr1542 Olr1541 Olr1540 Olr1445 Sox9 Nck2 LOC103693022 LOC100912463 Smad3 Ccnt2 Smad2 Pard6a Nedd8 Fkbp1a Strap Usp9x Sp1 Ube2d1 Skil Rbl1 Ncor2 Cdk9 Mtmr4 E2f4 Zfyve9 Hdac1 Tgif2 Tgif1 Atp1b4 Trim33 Pmepa1 Ccnk Ube2d3 Pard3 Bambi Wwtr1 Tfdp1 Prkcz Tfdp2 Stub1 Tas2r144 Grm3 Casr Grm1 Grm6 Tas2r113 Grm2 Grm8 Srms Tas2r114 Tas2r110 Ptk6 Gprc6a Wwp1 Tas2r124 Tas2r125 Tas2r126 Tas2r121 Tas2r103 Tas2r104 Tas2r123 Tas2r116 Tas2r140 Tas2r120 Tas2r102 Tas2r145 Tas2r119 Tas2r118 Tas2r117 Pde1b Tas2r107 Tas2r108 Tas2r105 Tas2r106 Tas2r129 Tas2r109 Tas2r136 Tas2r137 Tas1r1 Tas2r135 Tas2r13 Tas2r130 Tas1r3 Tas2r139 Apob Apoc2 Apoe Apoa2 Gng10 Arhgef6 Arhgef5 Arhgef39 Arhgef7 Arhgef37 Arhgef38 Il2rg Pdgfra Arhgef33 Pdgfrb Prex1 Adra1a Tbxa2r Itsn1 Arhgef2 LOC102556447 Arhgef4 Arhgef3 Plekhg5 Arhgef19 Arhgef18 Plekhg2 Kalrn Adra1d Plxnb1 LOC100912512 Gna12 Vav2 Gna13 Flrt1 Vav1 Arhgef11 Flrt2 Akap13 Arhgef16 Arhgef15 Pbp2 Net1 Dusp9 Ect2 Dusp2 Arhgef26 Dusp5 Fgd2 Mcf2l Rasal3 Tiam1 Csk Tiam2 Rasal1 Rasal2 Vav3 Rasgrp1 Pebp1 Rasgrp4 Rasgrp3 Pea15 Fgd3 Dusp1 Sos2 Ngef Mark3 Araf Rasa4 Il5 Spred1 Spred2 Rasgef1a Il2 Rasa2 Rasa3 Trpc3 Il2ra Trpc7 Csf2 Il3ra Nf1 Kit Trpc6 Syngap1 Kitlg Il2rb Olr1600 Dusp16 Olr1605 Map3k11 Csf2ra Olr1405 Olr1601 Csf2rb Ksr1 Olr1407 Rapgef2 Olr1404 Wdr83 Olr1406 Ksr2 LOC100910837 Olr1368 Raf1 Olr1369 Ppp5c Olr226 Il17rd LOC100911348 Il5ra Cnksr1 Olr229 Cnksr2 Olr227 Olr1602 Dusp10 LOC684170 Paqr3 LOC103692138 Olr1504 Olr233 Olr428 Olr232 Olr427 Olr1505 Olr234 LOC100911377 Olr1400 LOC100911376 Ccne1 Olr231 RragB Ptgdr Prkab1 Olr425 Nphp4 Prkab2 Olr1501 Olr230 Disp2 Olr208 Adcy8 Olr1202 Olr244 Rpgrip1l Adcy9 LOC103693685 Adcy5 Olr1519 Adcy4 Olr203 Adcy7 Olr411 Adcy6 Olr209 Prkar1b Rasgrp2 Olr1007 Prkar1a Olr1006 LOC100911223 Stap2 Smo Olr237 Wdr35 Olr434 Olr1306 Evc2 Olr442 Kif3a Ift88 Olr441 Dnal4 Olr113 Olr210 Ralgds Olr1520 Kidins220 Olr114 Olr1523 Olr218 Olr1522 Olr1521 Olr206 F2rl3 F2r Olr1118 Olr204 F2 Olr205 LOC100911398 Ptger2 Pip4k2b Pip4k2c Olr1115 Olr1117 F2rl2 Pde7a Hebp1 Olr1734 Fpr-rs6 Olr1340 Olr485 Olr486 Fpr-rs3 Olr16 Fpr2 Olr1735 Fpr3 Anxa1 LOC100911043 Olr1737 Olr14 Olr1736 Olr488 Fpr-rs4 Olr484 Pde7b Olr1730 LOC100912515 Olr1627 Olr491 Olr1626 Olr490 Olr1621 LOC100912408 Olr1625 Olr1624 Olr200 Olr339 Olr1345 Olr338 Olr1343 Olr202 Olr1344 Olr1341 Olr1356 Mtor Taar9 LOC100912605 Rheb LOC100911849 Hrh2 Prkag3 LOC100910199 Rptor Fshb Taar6 Agt Lamtor4 Olr346 Taar5 Tsc1 Taar2 Lamtor5 Olr1214 Olr450 Mlst8 Prkaa1 Olr499 Olr496 Tsc2 Rraga LOC100912505 Prkaa2 Olr493 Olr1606 Rragc Olr1607 Akt3 Olr1749 Rragd Olr1608 Slc38a9 Olr1362 Olr459 Olr458 Olr1361 Olr1366 Olr1364 Olr360 Olr462 Olr1611 Olr1610 Olr1358 Olr1612 Olr20 Olr24 Olr23 Olr1456 LOC100912431 Olr1597 Olr1593 Olr1592 Olr1450 Olr1452 Olr1598 Olr1454 LOC100909966 LOC100365887 LOC100912159 Olr1654 LOC103693822 Olr30 Olr32 Olr34 Olr331 Olr332 Olr1643 Olr334 Olr330 Olr1642 Olr1644 Olr1645 Olr473 Olr470 Olr1744 Olr1641 Olr1743 Olr1746 Olr472 Olr1640 Pde8b Smurf1 Olr477 Olr475 Pde8a Tgfbr1 LOC100911479 Olr1235 Ube2m Olr1738 E2f5 LOC103690286 Cbl Olr1231 Hdac1l Olr329 Snw1 Tgfbr2 Or7e24 Cgn LOC103690280 Olr326 Olr325 Olr1339 Olr1639 Olr13 Olr12 Olr1637 Olr1638 Olr340 Olr341 LOC102555599 Olr1635 Olr1630 Olr1631 Olr1632 Olr1633 Olr1423 Mks1 Ccnd3 Cdc73 Olr1560 Olr63 Csnk1a1 LOC100912684 RGD1564313 Dzip1 Olr1424 Sufu Olr1564 Dhh Olr1425 Cdon Olr1422 Shh Olr1558 Ptch1 Olr1559 LOC684179 Efcab7 Spop Olr1555 Ptgdrl Iqce Olr67 Tert Spopl Olr68 Ofd1 Olr69 Ulk3 Olr1416 Boc Olr70 Gli1 Olr1418 Gli3 Olr1417 Gli2 Adcy3 Olr1551 Prkar2b Olr1557 Prkar2a Olr1553 Ihh LOC686967 Olr77 Ift122 LOC100909611 Os9 Olr1693 Evc Rtp4 RGD1559714 Wdr19 Olr74 Ttc21b RGD1562400 Olr78 RGD1563667 Olr75 Erlec1 Olr1583 Olr1589 Olr1488 LOC100912420 Olr1582 LOC100909993 Rtp3 Rtp2 Olr1475 Olr1470 LOC687110 Olr1576 Olr49 Olr46 Olr1588 Olr48 Olr1467 Pygo2 Arrb1 Olr1468 Ift52 Olr1469 Kif7 Olr50 Arrb2 Olr51 Ift57 Olr59 Gas1 Csnk1e Hhip Olr1671 Gas8 Olr1471 Olr1667 LOC689173 Tcf7 Olr29 Lef1 LOC100909831 Adrbk1 Tcf7l1 Olr27 Gpr161 Bcl9l Olr25 Scube2 Tle4 Olr1462 Ift140 Tle1 Sel1l Tle2 LOC100912540 LOC100911586 Tulp3 Pygo1 Faslg Cenpn Zwilch Cenpl Cflar Fadd Cenpo Klc1 Dync1li2 Cilp Cenpt Cenpu Maml1 Abi1 Bub3 Rbpj Nlk Bub1 Kat2a Abi2 Potef Spdl1 Kntc1 Rbpjl2 Dync1i2 Mad1l1 Rtkn Myh9 Nck1 Casp3 Cenpk Cenph Cenpi Rock2 Klc4 Cenpf Kdm1a Cenpe Cenpm Tradd Tnfsf10 Klc2 Ahctf1 Fas Klc3 Ndel1 Mknk1 Rcc2 Esrp2 Noxo1 Esrp1 Arpc1b Rbfox2 LOC100909750 Pafah1b1 Fgfrl1 Rhpn1 Tia1 Tial1 Ncf1 Fgfbp3 Ncf4 Rhpn2 Fgfbp1 Ppp1r12a Spry2 LOC100361515 Mis12 Dynll2 Ndc80 Cenpc Sqstm1 Noxa1 Pdgfc Ppp1r14a Pdgfd Thbs4 Cenpa Dync1i1 Plat Daam1 Srgap2 LOC100909840 Ptk2 Actg1 Cyfip2 Birc5 Nckap1 Taok1 Sh2d2a Hspb1 Flt4 Ccr6 LOC100911280 LOC100909609 Flt1 Ptk2b Pxn Figf Shc2 Vegfc Nrp1 Nrp2 Vegfb Axl Pgf Ntrk1 Ngf Apoa1 Oxtr Oxt LOC100909648 Avpr1b Avpr1a Dock1 Ctnnd1 Cdh5 Elmo2 Myh14 Myh11 Cdca8 Ghrh Ramp3 Flna Pkn1 Vipr2 Sct Evl C5ar2 Tax1bp3 Gip Pkn2 Gipr Pth1r Pkn3 Ptpn3 Brk1 Iapp Cdc25c Crhr2 Gcgr Rangap1 Adgre1 Cd19 Fmnl1 Crhr1 Ppp1cb Glp2r Baiap2 Pth2 Ppp1cc Ramp2 LOC100909468 Ghrhr Aurkb Limk1 Sec13 Nf2 Xpo1 Pak2 Pak3 Pak1 Rac2 Ptprk Wasl LOC100911204 Spry1 Spc24 Spc25 Nox3 Nox1 Abl1 Itgb3bp Sgol2 Rhod Wasf1 Arpc4 Ppp2r5e Incenp Rhoq Ktn1 Arpc3 Nsl1 LOC102551071 B9d2 Cdc20 Kif2a Kif2c Kif2b Men1 Bub1b Kif18a Ppp2r5c Ppp2r5a Nckipsd LOC100361457 Ppp2r5b Zwint Mylk Kif5b Mad2l1 Kif5a Casc5 Actr3 Lin7b Was Clasp2 Ercc6l Ctnna1 Nuf2 Mapk13 Pik3c3 Mapk12 Ncoa2 Dscam Clasp1 LOC679582 Iqgap3 Dvl1 Mkl1 Pik3r4 Pdpk1 Mapre1 Cdc42 LOC100911597 Pmf1 Dvl2 Dvl3 Pfn1 Pfn2 Ckap5 Scai Ska2 Wipf1 Wipf2 Wipf3 Sgol1 Zw10 Srf Ska1 Arhgap18 Arhgap19 Psmc6 Arhgap21 Arhgap17 Psmb10 Myo9a Arhgap22 Arhgap10 Psmb8 Arhgap20 Psmb9 Srgap1 Psmb4 Srgap3 Psmb11 Arhgap39 Psmb5 Rhobtb2 Psmf1 Arhgap36 Psmb6 Psmd4 Depdc1b Arhgap44 Psmb2 Arhgap35 Psmd5 Arhgap5 Psmd8 Arhgap6 Psmd9 Arhgdib Psmb3 Rhoj Ralbp1 Psma8 Rhoh Depdc7 Arhgap11a Dlc1 Syde1 Syde2 Fam13a Fam13b Gmip Arhgap15 Arhgap12 Arap1 Stard13 Tagap Chn2 Stard8 Ophn1 Arhgap1 Arhgap8 Rhot2 Rhot1 Pth Sctr Adm Crhbp Calcb Vip Calca Ramp1 Htr2c Htr2a Adcyap1r1 Ucn Dgkk Dgki Adcyap1 Ucn2 Pth2r Adm2 Crh Htr2b Ccl9 Ccl6 Dgkg Gpr4 Dgkd Dgke Dgka Dgkb Gnb3 Gpr132 Gnb5 Gpr143 Rgs3 Opn4 Gnb2 Gnb1 Rgs19 Gng13 Rgs2 Gng12 Rgs18 Gng11 Hrh1 Arhgap26 Chrm1 Prkaca Arhgap25 Chrm5 Prkacb Arhgap29 Itpr1 Ghsr Arhgap23 Arhgef25 Arhgap28 Dgkz Rapgef4 Arhgap27 Itpr3 LOC100909523 Arhgap42 Dgkq LOC100912034 Arhgap40 Dgkh Gnb4 Glp1r Cysltr2 Camk4 Gcg Cysltr1 Gpr65 Gng4 Gpr68 Gngt2 Arhgap32 Ptgfr Gng5 Gngt1 Prkch Arhgap30 Ptger1 Gng8 Arhgap31 Chrm3 Gng3 Agtr1b Agtr1a Eps15l1 Fgf23 Memo1 Fgf22 Fgf4 Fgf1 Fgf3 Chrm2 Tlr9 Fgf6 Fgf5 Ltb4r Ffar2 Ffar3 Ltb4r2 Avp Ppid Fgf20 Ppidl1 Gab1 Pde3b Igf2 Igf1 Fgf16 Fgf17 Irs2 Fgf10 Fgf9 Fgfr2 Fgf7 Fgf8 Fgfr3 Trib3 Fgfr1 Fgfr4 Grb10 Insr Ins1 Ins2 Fgf19 Them4 Irs1 Frs2 Akt2 P2ry6 Lpar6 P2ry4 P2ry1 Gpr17 Lpar4 P2ry12 P2ry2 P2ry10 P2ry13 Psmc5 Psma1 Psma4 Psmc1 Psma3 Psmc4 Psma6 Psme1 Psme2 Adrb2 Tacr1 TRAF6 MEDIATED IRF7 ACTIVATION%REACTOME DATABASE ID RELEASE 66%10145758 TRAF6 mediated IRF7 activation Irf3 Crebbp Myd88 Dhx36 NEUROTRANSMITTER RECEPTORS AND POSTSYNAPTIC SIGNAL TRANSMISSION%REACTOME%R-RNO-112314.1 Neurotransmitter receptors and postsynaptic signal transmission Plcb1 Mdm2 Raf1 Plcb3 Ap2a2 Adcy8 Adcy9 Adcy5 Adcy4 Adcy7 Adcy6 Gabrr1 Gabrr3 Gabrr2 Gnai3 Gnal Gnat3 Prkcb Nsf Ap2s1 Ap2a1 Myo6 Ap2m1 Camkk1 Gnb3 Kcnj16 Gnb5 Gnb2 Gnb1 Gng13 Chrne Gng12 Chrnd Mapk1 Gng11 Cacng8 Creb1 LOC100912034 Prkca Gnb4 Cacng2 Cacng3 Camk4 Gng4 Cacng4 Gngt2 Gng5 Gngt1 Gng8 Dlg4 Gng3 Grin2d Camk2g Grin2b Grin1 Chrnb4 Nefl Rasgrf1 Dlg1 Dlg2 Glra4 Htr3b Dlg3 Htr3a Camk2d Actn2 Camk2a Glrb Rps6ka2 Rps6ka1 Rps6ka3 Chrna4 Chrna5 Chrna9 Chrna6 Chrnb2 Chrna7 Chrnb3 Chrna2 Chrna3 Chrna1 Kcnj2 Kcnj3 Kcnj15 Kcnj9 Kcnj5 Gabbr1 Kcnj12 Gabbr2 Gng10 Rras Kcnj4 Kcnj6 Gria3 Gria4 Grip1 Grip2 Pick1 Lrrc7 Adcy3 Akap5 Gabra5 Gabra6 Gabrb1 Gabrg2 Gabra1 Gabra2 Gnai2 Grik1 Grik3 Grik2 Ncald Grik5 Pdpk1 Rps6ka6 Hras Gnai1 Gabra4 Gabrb2 PLASMALOGEN BIOSYNTHESIS%REACTOME%R-RNO-75896.1 Plasmalogen biosynthesis Gnpat Agps TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING%REACTOME%R-RNO-975110.1 TRAF6 mediated IRF7 activation in TLR7 8 or 9 signaling LOC100362142 Tlr7 Tlr8 Tlr9 Irak4 Ube2n LOC100912618 Ube2v1 Myd88 Traf6 Dhx36 ABACAVIR TRANSMEMBRANE TRANSPORT%REACTOME%R-RNO-2161517.1 Abacavir transmembrane transport Slc22a1 Slc22a2 Slc22a3 RNA POLYMERASE I PROMOTER CLEARANCE%REACTOME%R-RNO-73854.1 RNA Polymerase I Promoter Clearance Gtf2h1 Gtf2h2 Mnat1 RGD1565904 Ubtf Polr1b Taf1d Taf1c Polr2h Cd3eap Polr2e Znrd1 Polr2f Polr1c Polr2k Polr1a Ttf1 Hist1h2bo Hist1h2bcl1 Hist2h3c2 LOC100912534 Rrn3 Hist1h2bk H3f3b Hdac2 Mbd3 Hdac1l Chd3 Chd4 Ccnh Mta3 Gtf2h3 Mta1 Mta2 Gatad2a Gtf2h5 Tbp Gtf2h4 Gatad2b LOC100910200 H2afx Hist1h4b LOC684841 Hist1h2bh LOC100912290 Rbbp7 Hist1h2ail1 Hist1h4m LOC102549173 LOC103690002 Ehmt2 LOC100910152 LOC100912338 Hist1h3c Hdac1 Ercc3 H2afb3 Hist1h3f Ercc6 Hist2h4 LOC684819 Hist1h3a H2afj Hist2h2aa3 Hist1h2bq Hist2h2aa2 Ercc2 LOC100364835 LOC684762 Cdk7 Twistnb Polr1e Hist1h2bg Mbd2 LOC680097 LOC684797 LOC100912418 Hist1h2ba Hist3h2bb LOC100910121 FCERI MEDIATED NF-KB ACTIVATION%REACTOME%R-RNO-2871837.1 FCERI mediated NF-kB activation Psmc6 Psmb10 Psmb8 Psmb9 Psmb4 Psmb11 Psmb5 Psmf1 Psmb6 Psmd4 Traf6 Psmb2 Cul1 Psmd5 Psmd8 Psmd9 Psmb3 Psma8 Psmd11 Cdc34 Psmd12 Tab1 Psmd13 Rela Psmd14 Map3k7 Prkcq Psmc3 Nfkbia LOC100910771 Ube2n Bcl10 G6pc Ube2d1 Psmb7 Psmb1 Skp1 Nfkb1 Psma5 Fbxw11 Chuk Btrc Pdpk1 Psma2 Psmc5 Psmd2 LOC100362142 Psma1 Psma4 Psmc1 Psma3 Psmc4 Psmc2 Tab2 Psma6 Tab3 Psme1 Lyn LOC100912618 Psmd1 Psme2 Ube2v1 Psmd7 Ikbkb Psmd3 Psmd6 THE AIM2 INFLAMMASOME%REACTOME%R-RNO-844615.1 The AIM2 inflammasome Aim2 FORMATION OF RNA POL II ELONGATION COMPLEX%REACTOME%R-RNO-112382.1 Formation of RNA Pol II elongation complex Gtf2h1 Gtf2h2 Mnat1 RGD1565904 Leo1 Polr2g Polr2h Polr2e Polr2f Supt16h Polr2j Polr2k Polr2d Ctr9 Polr2i Polr2b Polr2c Polr2a Wdr61 Gtf2f1 LOC100912534 Gtf2f2 Ell Tceb2 Tceb1 Iws1 Tcea1 Ccnh Gtf2h3 Paf1 Gtf2h5 Gtf2h4 Cdc73 Aff4 Ccnt2 Tceb3 Rtf1 Cdk9 Supt6h Eaf1 Eaf2 Ercc3 Ccnk Supt5h LOC100911822 Mllt1 Ercc2 Ncbp2 Ncbp1 Supt4h1 Cdk7 Nelfe Nelfa Nelfb Ssrp1 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%R-RNO-427413.1 NoRC negatively regulates rRNA expression LOC100910200 H2afx Hist1h4b LOC684841 Hist1h2bh LOC100912290 Hist1h2ail1 Hist1h4m LOC102549173 LOC103690002 LOC100910152 LOC100912338 Hist1h3c H2afb3 Hist1h3f Hist2h4 LOC684819 Hist1h3a H2afj Hist2h2aa3 Hist1h2bq Hist2h2aa2 LOC100364835 LOC684762 Hist1h2bo Hist1h2bcl1 Hist2h3c2 Hist1h2bk H3f3b Hist1h2bg Mbd2 LOC680097 LOC684797 LOC100912418 Hist1h2ba Hist3h2bb FGFR3C LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 66%10145291 FGFR3c ligand binding and activation Fgf23 Fgf4 Fgf1 Fgf16 Fgf17 Fgf5 Fgf9 Fgf2 Fgf8 Fgfr3 Fgf20 Galnt3 FATTY ACID METABOLISM%REACTOME%R-RNO-8978868.1 Fatty acid metabolism Ndufab1 Cyp1b1 Ptgds Tecr LOC683884 Echs1 Nudt7 Abcd1 Dpep3 LOC100365676 Dpep1 Acly Hsd17b3 Hsd17b8 Acot6 Acot4 Acsbg1 Acot8 Acox1 Ehhadh Eci3 Hsd17b4 Mlycd Acoxl Prkab2 Acsbg2 Slc22a5 Awat1 Alox5ap Cpt1b Eci1 Cpt1a Akr1c12l1 Mid1ip1 LOC100910957 Mcat Hpgds Akr1c19 Acot11 Slc25a17 Thrsp Cyp4f17 Akr1c13 Acot13 Akr1c14 RGD1564865 LOC681458 Slc25a20 Akr1c12 Cyp4f18 Fasn Amacr Tbxas1 Cyp4f39 Tecrl Mut Pon3 Ptges2 Ppt1 Pon1 Ppt2 Pon2 Alox5 Acadvl Lta4h Acsl3 Acsl1 Acsl6 Acsl5 Acsl4 LOC100361547 Acox3 Gpx4 Acox2 Aldh3a2 Slc27a2 Acaa2 Cyp2u1 Cyp4f6 Mapkapk2 Prkaa2 Cyp2c7 Alox12 Alox15b Cbr1 Ltc4s LOC100912391 Acbd7 Cpt2 Acad10 Acad11 Mcee Cyp1a1 Ptgs1 Acbd5 Hacl1 Ptgs2 Acbd6 Ephx2 Cyp1a2 Alox15 Mmaa Acbd4 Cyp2c6v1 Cyp4a2 Cyp4a1 Phyh Ptgis Rxra Aloxe3 Cyp4a8 LOC688708 LOC100912469 Pctp Pla2g4a Cbr4 LOC102556347 Acot7 Acot9 Ppard Acadl Acot2 Cyp2j10 Acads Acot5 Acadm Acaa1a Acaa1b Akr1c2 Scd4 Hao2 Akr1c3 Ptges3 Ptges3l1 LOC100911186 Them5 Acsf2 Scd1 Scd2 Acsf3 Dbi Them4 Morc2 Akr1c1 LOC100911941 Fads1 Dpep2 Ptges Faah Elovl1 Elovl5 Slc25a1 Elovl2 Elovl3 Crot Elovl6 Morc2b Decr1 Hacd1 Hadh Hadha Hadhb Cyp8b1 Crat Pccb Hacd4 Hacd3 Hsd17b12 TNF RECEPTOR SUPERFAMILY (TNFSF) MEMBERS MEDIATING NON-CANONICAL NF-KB PATHWAY%REACTOME DATABASE ID RELEASE 66%10145372 TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway Tnfsf13b Cd40lg Birc3 Birc2 Cd40 Traf3 Prmt2 Traf2 Tnfrsf11a Map3k14 Tnfsf14 Tnfsf12 Tnfrsf12a Tnfrsf13c Tnfsf11 Lta Ltb Ltbr VEGFR2 MEDIATED VASCULAR PERMEABILITY%REACTOME%R-RNO-5218920.1 VEGFR2 mediated vascular permeability Mtor Ctnna1 Vav3 LOC103692716 Mlst8 Trib3 Jup Akt1 Rac1 Pdpk1 Mapkap1 Akt3 Nos3 Pak2 Pak3 Pak1 Ctnnd1 Vav2 Them4 Cdh5 Vav1 Akt2 Rictor PI5P, PP2A AND IER3 REGULATE PI3K AKT SIGNALING%REACTOME%R-RNO-6811558.1 PI5P, PP2A and IER3 Regulate PI3K AKT Signaling Ereg Cd80 Nrg1 Cd86 Btc LOC102552659 Erbb3 Erbb2 Nrg3 Egfr Hbegf Esr2 Rac1 Traf6 Nrg4 Fgf23 Fgf22 Fgf4 Fgf1 Il33 Fgf3 Fgf6 Fgf5 Fgf20 Gab1 Pip5k1c Pip5k1b Fgf16 Fyn Pip5k1a Fgf17 Irs2 Fgf10 Fgf9 Fgfr2 Fgf7 Cd19 Fgf2 Fgf8 Fgfr3 Il1rap Fgfr1 LOC100909468 Fgfr4 Hgf Esr1 Insr Ins1 Rac2 Ins2 Fgf19 Erbb4 Irs1 Frs2 Pip4k2b Pip4k2c Nrg2 Src Ppp2r5e Pik3r1 Pik3r3 Pdgfra Pik3r2 Pdgfrb Pik3ap1 Il1rl1 Akt1 Cd28 Icos Ppp2r5c Ppp2cb Pdgfa Ier3 Ppp2r5a Ppp2ca Pdgfb Ppp2r1a Ppp2r5b Pik3cd Vav1 Irak4 Ppp2r1b Mapk1 Pik3cb Ptpn11 Rhog Kit Myd88 Kitlg Grb2 FGFR1 LIGAND BINDING AND ACTIVATION%REACTOME%R-RNO-190242.1 FGFR1 ligand binding and activation Fgf17 Fgf10 Fgf9 Fgf2 Fgf8 Fgfr1 Fgf23 Fgf22 Fgf4 Fgf1 Fgf3 Fgf6 Fgf5 Fgf20 SYNTHESIS OF PIPS AT THE ER MEMBRANE%REACTOME DATABASE ID RELEASE 66%10145900 Synthesis of PIPs at the ER membrane Mtmr2 Sbf1 Sacm1l Pi4k2b RHO GTPASES ACTIVATE IQGAPS%REACTOME DATABASE ID RELEASE 66%10146088 RHO GTPases activate IQGAPs Men1 Ctnna1 Iqgap3 Iqgap1 Rac1 Cdh1 Cdc42 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 66%10145527 Recruitment of NuMA to mitotic centrosomes Dync1i2 Tubgcp2 Cep57 LOC691918 Haus3 Ninl Akap9 Ccp110 Dync1h1 Pafah1b1 LOC103692716 Numa1 Dctn1 Cntrl Dctn2 Cep76 Pcm1 Cep78 LOC100911033 Cep164 Dctn3 Cep41 Ofd1 Sdccag8 Tubb5 Prkar2b Cenpj Ywhag Ppp2r1a Plk4 Ywhae LOC100912076 Tubg2 Haus2 Haus1 Haus5 Alms1 Haus4 Clasp1 Odf2 Tubb4a Cdk1 Nek2l1 Ssna1 Mapre1 Tubg1 Cep63 Prkaca Csnk1d Cep131 Tuba4a Cep250 Cep135 Csnk1e Ckap5 Cdk5rap2 Nme7 Tubgcp5 Pcnt Nek2 Tubgcp6 Cep72 Tubgcp3 Sfi1 Tubgcp4 Cep70 Actr1a Mzt1 Nedd1 Mzt2b GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION%REACTOME%R-RNO-163841.1 Gamma carboxylation, hypusine formation and arylsulfatase activation Dph1 Ggcx Dph3 Dohh Dph2 Dph5 Gas6 Eif5a2 Dph6 Fn3krp Arsa Furin Arsi Eif5a Arse Icmt Arsg Proz Arsk Sts Arsb Sumf2 Fn3k Sumf1 Pros1 Eef2 Bglap F2 Dhps F7 F9 GLYCINE DEGRADATION%REACTOME DATABASE ID RELEASE 66%10146148 Glycine degradation Amt Gcsh Dld Gldc TANDEM PORE DOMAIN POTASSIUM CHANNELS%REACTOME DATABASE ID RELEASE 66%10145839 Tandem pore domain potassium channels Kcnk16 Kcnk1 Kcnk13 Kcnk2 Kcnk3 LOC100909725 Kcnk4 Kcnk18 Kcnk10 Kcnk6 Kcnk9 Kcnk7 DEGRADATION OF THE EXTRACELLULAR MATRIX%REACTOME%R-RNO-1474228.1 Degradation of the extracellular matrix Cd44 Capn5 RGD1308751 Capn7 Capn9 Capn8 LOC683849 Furin Tpsb2 Cts8l1 Spock3 Htra1 Nid1 LOC100910122 Bmp1 Cast Elane Adam8 Bsg Col13a1 LOC103690254 Try10 LOC100365995 Timp2 Timp1 Phykpl Cma1 Cdh1 Col18a1 MGC114246 A2m Capn15 Capn1 Capn6 Scube3 Scube1 Capn3 Capn2 Capn10 Testin Plg Capn12 Capn11 Capn13 Mmp8 Mmp7 Col19a1 Mmp9 Try4 Mmp1 Mmp2 Lamc2 Acan Adam15 Bcan Klk7 Prss2 LOC100910284 LOC100364523 Ctrb1 Optc Lamb3 Prss1 Spp1 Mmp15 Mmp17 Mmp11 Mmp12 Mmp14 Mmp13 Mmp19 Adamts4 Dcn Adamts5 Klkb1 Ctsd Ctsb Ctsg Ctsl Ctsm Ctsj RGD1564657 Ctsk Ctsq Ctsr LOC102554637 Tll2 Mmp20 Tmprss6 Tll1 Tpsab1 Mmp24 Cts8 Cts7 Col26a1 RGD1564827 Mmp16 Mmp10 ACYL CHAIN REMODELLING OF PG%REACTOME DATABASE ID RELEASE 66%10145863 Acyl chain remodelling of PG Lpcat4 Pla2r1 Pla2g3 Lpcat1 Pla2g5 Pla2g4b Pla2g4d Lpgat1 Pla2g2a Pla2g2f LOC317456 Pla2g2d Pla2g10 Pla2g1b Pla2g4a Crls1 Pla2g12a ACYL CHAIN REMODELING OF DAG AND TAG%REACTOME%R-RNO-1482883.1 Acyl chain remodeling of DAG and TAG Pnpla3 Awat2 Pnpla2 LOC100911615 Mgll Dgat2 Dgat2l6 Dgat1 NUCLEAR ENVELOPE BREAKDOWN%REACTOME DATABASE ID RELEASE 66%10145982 Nuclear Envelope Breakdown Nup93 Nup43 Nup98 Nup133 Nup107 Aaas Nup155 Lemd3 Lmna Nup210 Npap60 Nup35 Ctdnep1 Nup88 Nup37 Prkcb Nupl2 Tmpo Nupl1 Nup85 Nup153 Cnep1r1 Tpr Cdk1 Lmnb1 Rae1 Lemd2 Nup54 Lpin2 Prkca Lpin3 Lpin1 Nup205 Pom121 Nek6 Ranbp2 Nup62 Nek7 APC:CDC20 MEDIATED DEGRADATION OF CELL CYCLE PROTEINS PRIOR TO SATISFATION OF THE CELL CYCLE CHECKPOINT%REACTOME%R-RNO-179419.1 APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint Psmc6 Psmb10 Psmb8 Psmb9 Psmb4 Psmb11 Bub3 Psmb5 Psmf1 Psmb6 Psmd4 Psmb2 Psmd5 Psmd8 Psmd9 Psmb3 Psma8 Psmd11 Psmd12 Anapc11 Ccna2 Ccna1 Anapc15 Psmd13 Anapc10 Psmd14 Psmc3 G6pc Ube2d1 Cdc20 Psmb7 Psmb1 Bub1b Mad2l1 Anapc7 Cdc26 Cdc27 Cdc23 Psma5 Ube2c Cdk1 Anapc16 Cdc16 Nek2l1 Anapc4 Psma2 Anapc2 Anapc1 Psmc5 Psmd2 Psma1 Psma4 Psmc1 Psma3 Psmc4 Psmc2 Psma6 Psme1 Nek2 Psmd1 Psme2 Psmd7 Psmd3 Psmd6 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC%REACTOME DATABASE ID RELEASE 66%10145414 Antigen Presentation: Folding, assembly and peptide loading of class I MHC RT1-CE2 RT1-CE3 Sec24a RT1-CE4 Sec24b RT1-CE7 RT1-CE5 Sec24d RT1-CE10 Canx RT1-A Calr RT1-A2 RT1-M3-1 Erap1 RT1-A1 Hspa5 B2m Tap1 Sec23a Tap2 RT1-M6-1 Sec31a LOC683761 LOC100364956 Sec13 RT1-M2 RT1-M6-2 Sar1b LOC100364500 RT1-M5 Tapbp RT1-M4 RT1-S3 Sec24c BLOCH PATHWAY%REACTOME%R-RNO-6807047.1 Bloch pathway Ebp Dhcr7 Sc5d Dhcr24 RNA POLYMERASE I PROMOTER ESCAPE%REACTOME%R-RNO-73772.1 RNA Polymerase I Promoter Escape Gtf2h1 Gtf2h2 Mnat1 RGD1565904 Ubtf Polr1b Taf1d Ercc3 Taf1c Polr2h Cd3eap Polr2e Znrd1 Polr2f Polr1c Polr2k Polr1a Ercc2 LOC100912534 Rrn3 Cdk7 Twistnb Polr1e Ccnh Gtf2h3 Tbp Gtf2h5 LOC100910121 Gtf2h4 HDR THROUGH MMEJ (ALT-NHEJ)%REACTOME DATABASE ID RELEASE 66%10146137 HDR through MMEJ (alt-NHEJ) Rbbp8 Xrcc1 Parp2 Fen1 Parp1 Lig3 Polq Nbn Rad50 Mre11a ALPHA-DEFENSINS%REACTOME%R-RNO-1462054.1 Alpha-defensins Defa7 Np4 Defa11 RatNP-3b Defa10 Defa5 Cd4 Art1 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE%REACTOME DATABASE ID RELEASE 66%10145161 Toll Like Receptor 3 (TLR3) Cascade Map2k7 Ripk2 Map2k6 Ager Dusp3 Irf3 Map2k4 Map3k8 Dusp4 Nfkbib Traf6 Cul1 Vrk3 Rps6ka2 Rps6ka1 App Rps6ka3 Rps6ka5 LOC100912585 Tab1 Dusp7 Dusp6 Rela Atf1 Atf2 Map3k7 Irak2 Nfkbia LOC100910771 Ube2n Jun Ppp2cb Ppp2ca Skp1 Ppp2r1a Nfkb2 Nfkb1 Mapk9 Mapk8 Fos S100b Mapk7 Dhx9 Fbxw11 Chuk Ppp2r1b Mapkapk3 Btrc Mapkapk2 Mapk1 Nkiras1 LOC100362142 Nod1 Nod2 Nkiras2 Creb1 Tab2 Tab3 LOC100912618 Ube2v1 Ikbkb Mapk14 Myd88 Tnip2 Mapk11 Mapk10 MET INTERACTS WITH TNS PROTEINS%REACTOME DATABASE ID RELEASE 66%10146251 MET interacts with TNS proteins Hgf Tns4 INTERFERON GAMMA SIGNALING%REACTOME%R-RNO-877300.1 Interferon gamma signaling Prkcd Camk2g Socs1 Sumo1 Stat1 Jak1 Ifngr2 Pias1 Ifngr1 Camk2d Camk2a Socs3 Ptpn2 Ptpn6 Ifng MAJOR PATHWAY OF RRNA PROCESSING IN THE NUCLEOLUS AND CYTOSOL%REACTOME%R-RNO-6791226.1 Major pathway of rRNA processing in the nucleolus and cytosol Rps20 Rps27l LOC100360573 Rps4x LOC100359951 LOC100359593 LOC100359503 LOC100362640 Rps3 Rps15a Rps2 Rps13 Rps12 LOC100911372 LOC100361854 LOC684988 LOC103689992 Rps5 Rps7 Rps6 LOC100362830 LOC100363012 LOC100362149 Exosc3 Exosc9 LOC100359574 Exosc2 Exosc1 Exosc4 Exosc7 Exosc5 Dcaf13 Tbl3 Tsr1 Emg1 Wdr75 Wdr18 Wdr43 Wdr46 Nhp2l1 C1d Nob1 Fcf1 Wdr12 Senp3 Wdr36 Ebna1bp2 Rpp25 Riok3 Riok1 Utp14a Bysl NEWGENE_1564769 Rpp21 Pdcd11 Rpp40 Skiv2l2 Heatr1 Riok2 Rpp38 Rrp36 Rpp30 Bop1 Utp20 Dhx37 Utp18 Gnl3 Utp15 Utp11l Pno1 Pwp2 Wbscr22 Mphosph6 Imp4 Imp3 Nop56 Tex10 Utp6 Rcl1 Nol6 Utp3 Ncl Nop14 Xrn2 Rrp9 Rrp7a Pes1 Exosc10 Krr1 Nol9 Mphosph10 LOC100910568 Rpp14 Cirh1a Diexf Nop58 Ddx52 Rps16 Ltv1 Wdr3 Noc4l Ddx49 Ddx47 Las1l Fbl Rps18 LOC100360679 Rps15 Ddx21 Rps3a Csnk1d Csnk1e MET ACTIVATES STAT3%REACTOME%R-RNO-8875791.1 MET activates STAT3 Hgf Stat3 ERYTHROCYTES TAKE UP CARBON DIOXIDE AND RELEASE OXYGEN%REACTOME DATABASE ID RELEASE 66%10145817 Erythrocytes take up carbon dioxide and release oxygen Cyb5r2 Cyb5rl Rhag Hbb-b1 Hba1 Car2 Aqp1 Slc4a1 Cyb5r1 Car1 LOC287167 RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN BCR SIGNALING%REACTOME DATABASE ID RELEASE 66%10146269 RUNX1 regulates transcription of genes involved in BCR signaling Cbfb Elf2 Pax5 Runx1 G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%R-RNO-1296059.1 G protein gated Potassium channels Kcnj4 Kcnj6 Kcnj16 Gnb3 Gnb2 Gnb1 Gng12 Kcnj2 Kcnj3 Kcnj15 Kcnj9 Kcnj5 Gng4 Gngt2 Gabbr1 Gng5 Kcnj12 Gngt1 Gng10 Gng8 Gabbr2 Gng3 CLEARANCE OF SERATONIN%REACTOME%R-RNO-380615.1 Clearance of seratonin Maoa Aldh2 Slc6a4 MITOTIC PROMETAPHASE%REACTOME DATABASE ID RELEASE 66%10145506 Mitotic Prometaphase Cenpn Zwilch Cenpl Nup43 Cenpo Nup133 Dync1li2 Cenpt Cenpu Bub3 Bub1 Spdl1 Kntc1 Dync1i2 LOC100910252 Csnk2a2 Mad1l1 Cep57 Stag1 Cenpk Cenph LOC691918 Nup37 Cenpi Haus3 Csnk2a1 Pds5b Pds5a Cenpf Cdca5 Ninl Rad21 Cenpe Akap9 Smc1a Cenpm Stag2 Smc3 Ccp110 Ahctf1 Ndel1 Rcc2 Pafah1b1 Mis12 Dynll2 Ndc80 Cenpc Cenpa Dync1i1 Ranbp2 Birc5 Taok1 Tubb5 Ppp2cb Ppp2ca Ywhag Ppp2r1a Nup85 Ywhae Ppp2r1b Nek2l1 Prkaca Nek2 Nup98 Nup107 Tubgcp2 Dync1h1 Cdca8 Dync1li1 Rangap1 LOC103692716 Ppp1cc LOC100909468 Aurkb Numa1 Sec13 Xpo1 LOC100911204 Spc24 Spc25 Hdac8 Itgb3bp Sgol2 Dctn1 Cntrl Dctn2 Ppp2r5e Cep76 Incenp Pcm1 Cep78 Ncapg Nsl1 B9d2 LOC100911033 Cdc20 Cep164 Kif2a Dctn3 Kif2c Ofd1 Cep41 Kif2b Bub1b Sdccag8 Kif18a Ppp2r5c Ppp2r5a Prkar2b Cenpj Ppp2r5b Plk4 Zwint Smc4 Dsn1 Mad2l1 Smc2 Casc5 LOC100912076 Clasp2 Tubg2 Csnk2b Ercc6l Haus2 Haus1 Nuf2 Haus5 Alms1 Haus4 Clasp1 Odf2 LOC679582 Tubb4a Cdk1 Ssna1 Tubg1 Mapre1 Cep63 Cdc42 Csnk1d Cep131 Pmf1 Tuba4a Cep250 Cep135 Csnk1e Cdk5rap2 Ckap5 Nme7 Tubgcp5 Ska2 Pcnt Tubgcp6 Cep72 Tubgcp3 Sfi1 Tubgcp4 Cep70 Sgol1 Actr1a Zw10 Nedd1 Mzt1 Mzt2b Ska1 PLATELET SENSITIZATION BY LDL%REACTOME DATABASE ID RELEASE 66%10145634 Platelet sensitization by LDL Lrp8 Pla2g4a Fgr Apob Mapk14 Gnaq Gna11 Gna14 Gna15 REGULATION OF RUNX2 EXPRESSION AND ACTIVITY%REACTOME%R-RNO-8939902.1 Regulation of RUNX2 expression and activity Psmc6 Psmb10 G6pc Psmb8 Psmb9 Psmb4 Psmb5 Psmf1 Psmb6 Psmd4 Psmb2 Cul1 Rbx1 Psmd5 Psmd8 Psmb7 Psmd9 Psmb1 Psmb3 Skp1 Psmd11 Psmd12 Psmd13 Psmd14 Stub1 Psma5 Runx2 Skp2 Psma2 Psmc3 Psmc5 Psmd2 Psma1 Psma4 Psmc1 Psma3 Psmc4 Psmc2 Psma6 Psme1 Psmd1 Psme2 Psmd7 Psmd3 Psmd6 RAB GERANYLGERANYLATION%REACTOME%R-RNO-8873719.1 RAB geranylgeranylation Rab2a Rab2b Rab35 Rab34 Rab36 Rabggta Rab18 Rab8a Rab10 Rab27a Rab14 Rab3c Rab24 Rab3b Rab43 Rab7l1 Rab25 Rab20 Rab21 Rab19 Rab23 Rab15 Rab12 LOC102555167 Rab13 Rabggtb Rab32 Rab30 Rab39a Rab38 Rab11b Ptp4a2 Rab1b Rab1a Rab3d Rab4a Rab6b Rab27b Rab9a Rab3a Rab7a Rab4b Rab22a Rab8b Rab40c Rab40b Rab5b Rab5c Chm Rab11a Rab6a Rab7b Rab33a Rab33b Rab9b LOC100363782 NEUROTRANSMITTER UPTAKE AND METABOLISM IN GLIAL CELLS%REACTOME%R-RNO-112313.1 Neurotransmitter uptake and metabolism In glial cells Slc1a3 Slc38a1 Glul RAB GEFS EXCHANGE GTP FOR GDP ON RABS%REACTOME%R-RNO-8876198.1 RAB GEFs exchange GTP for GDP on RABs Trappc10 Madd Sbf1 Rab35 Rin3 Rab18 Rgp1 Rab8a Ulk1 Sbf2 Rab10 Rab27a Rab14 Trappc2l Gapvd1 Rab21 Dennd3 Trappc6a Trappc6b Rab12 Rab3ip Rab13 LOC102555167 Hps4 Rab32 Gdi2 Rab39a Hps1 Mon1b Mon1a Rab38 Rab1b Rab1a Dennd1a Trappc12 Trappc11 Akt2 Dennd1b Trappc2 Trappc5 Rab6b Rab27b Rab9a Ric1 Rab3a Akt1 Ccz1b St5 Rab7a Rab3gap2 Dennd6b Dennd6a Ywhae Trappc3 Rab8b Dennd5a LOC100910318 Rab3il1 Chm Trappc8 Rab6a Dennd4a Dennd4b Rab7b Akt3 Dennd2a Dennd2d Dennd2c Trappc13 Rab9b LOC100363782 Trappc1 PRESYNAPTIC DEPOLARIZATION AND CALCIUM CHANNEL OPENING%REACTOME%R-RNO-112308.1 Presynaptic depolarization and calcium channel opening Cacnb4 Cacna1e Cacnb1 Cacnb2 Cacna2d3 Cacng2 Cacna1b Cacna2d2 Cacng4 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING%REACTOME DATABASE ID RELEASE 66%10144894 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening Gtf2h1 Gtf2h2 Gtf2e1 Gtf2e2 Mnat1 RGD1565904 Taf11 Polr2g Ercc3 Taf2 Polr2h Taf15 Polr2e Polr2f Polr2j Taf13 Taf9 Polr2k Taf12 Polr2d LOC100911822 Taf7 Polr2i Taf4b Polr2b Polr2c Taf3 Ercc2 Taf6 Polr2a Taf5 Gtf2f1 LOC100912534 Gtf2f2 Gtf2a1 Cdk7 Atp5c1 Taf10 Taf7l Gtf2b Ccnh Gtf2h3 Gtf2h5 Tbp Gtf2h4 Taf9b HISTIDINE CATABOLISM%REACTOME%R-RNO-70921.1 Histidine catabolism Amdhd1 Carns1 Hnmt Hal Hdc Ftcd Uroc1 SIGNALING BY HIPPO%REACTOME DATABASE ID RELEASE 66%10145927 Signaling by Hippo Sav1 Amot LOC100361515 Dvl2 Casp3 Stk4 Stk3 Yap1 Mob1b Mob1a Wwc1 Lats1 Wwtr1 Tjp2 Ywhab Nphp4 Ywhae Amotl2 RIBOSOMAL SCANNING AND START CODON RECOGNITION%REACTOME DATABASE ID RELEASE 66%10144836 Ribosomal scanning and start codon recognition LOC100912571 Eif3l Eif2s3 Eif3m Eif3j Eif3k Rps20 Rps27l Eif3e Eif3f Eif3b Eif3a Eif3d Eif3c LOC100360573 Eif2s1 Eif2s2 Eif4g1 Rps4x LOC100359951 LOC100359593 Eif5 LOC100359503 LOC100362640 Rps3 Rps15a Rps2 Rps13 Rps12 LOC100911372 LOC100361854 LOC684988 LOC103689992 Rps5 Rps7 Rps6 Eif3g Eif3h Eif4a2 LOC100362830 Eif1ax Eif4a1 LOC100363012 LOC680559 LOC100911110 LOC100362149 Rps16 LOC100911431 Rps18 LOC100360679 Rps15 Eif4h Eif4b Rps3a PLATELET AGGREGATION (PLUG FORMATION)%REACTOME DATABASE ID RELEASE 66%10145477 Platelet Aggregation (Plug Formation) Src Ptpn1 Akt1 Fn1 Adra2a Csk Tln1 Crk Adra2c Rasgrp1 Rasgrp2 Rap1a Vwf Adra2b Apbb1ip Bcar1 Fgb Fgg Pdpk1 Gp1ba Gp9 Rapgef4 Gp5 Gp1bb LOC100911551 Fga Itga2b F2 Ptk2 Sos1 Shc1 Syk Grb2 HEME BIOSYNTHESIS%REACTOME%R-RNO-189451.1 Heme biosynthesis Cpox Fech Alad LOC687381 Ppox Hmbs Cox10 Alas2 LOC100911779 Cox15 Urod Uros NOD1 2 SIGNALING PATHWAY%REACTOME%R-RNO-168638.1 NOD1 2 Signaling Pathway Ripk2 Map2k6 Birc3 Birc2 Cyld Traf6 Tab1 Casp4 Casp1 Casp2 Map3k7 Casp8 Casp9 Tnfaip3 Irak2 Mapk13 Mapk12 Chuk LOC100362142 Nod1 Nod2 LOC100910771 Tab2 Ube2n Tab3 LOC100912618 Ube2v1 Ikbkb Mapk14 Mapk11 INTERLEUKIN-4 AND INTERLEUKIN-13 SIGNALING%REACTOME%R-RNO-6785807.1 Interleukin-4 and Interleukin-13 signaling Jak3 Socs1 Stat1 Il2rg Il4 Stat6 Jak1 Stat3 Il13 Il13ra1 Socs5 Hsp90b1 Il13ra2 LOC100360218 Tyk2 Il4r RELAXIN RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145665 Relaxin receptors Rln3 Rxfp1 Rxfp2 Insl3 Rxfp3 ORGANIC CATION ANION ZWITTERION TRANSPORT%REACTOME%R-RNO-549132.1 Organic cation anion zwitterion transport Slc22a7 Slc22a1 Slc22a15 Slc22a2 Slc22a6 Slc22a3 Runx1 Slc22a5 CARNITINE SYNTHESIS%REACTOME DATABASE ID RELEASE 66%10144812 Carnitine synthesis Shmt1 Tmlhe CAM-PDE 1 ACTIVATION%REACTOME DATABASE ID RELEASE 66%10145008 Cam-PDE 1 activation Pde1b HDR THROUGH SINGLE STRAND ANNEALING (SSA)%REACTOME DATABASE ID RELEASE 66%10144912 HDR through Single Strand Annealing (SSA) Rhno1 Rfc2 Bard1 Wrn Topbp1 Rbbp8 Rmi1 Rmi2 LOC100911267 Hus1 Rad51 Rad50 Rad52 Rpa1 Rpa2 Ercc1 Atm Atrip LOC100909750 Rpa3 Rad1 Brca1 Atr Blm Rad17 Slc25a16 Rfc5 Rfc4 Rad9a Nbn Rfc3 Rad9b Abl1 Mre11a FASL CD95L SIGNALING%REACTOME%R-RNO-75157.1 FasL CD95L signaling Faslg Fadd Casp8 Fas SUMO IS PROTEOLYTICALLY PROCESSED%REACTOME%R-RNO-3065679.1 SUMO is proteolytically processed Senp2 LOC690251 Senp1 Sumo1 Sumo3 Senp5 MAP2K AND MAPK ACTIVATION%REACTOME%R-RNO-5674135.1 MAP2K and MAPK activation Src Kras Ksr1 Wdr83 Ksr2 Raf1 Vcl Il17rd Cnksr1 Cnksr2 Lamtor3 Ywhab Fn1 Pbp2 Lamtor2 Csk Tln1 Vwf Rap1a Apbb1ip Pebp1 Fgb Fgg Mark3 Araf Mapk1 Arrb1 Arrb2 Fga Itga2b Hras Nras Iqgap1 Map2k2 ACTIVATION OF RAS IN B CELLS%REACTOME%R-RNO-1169092.1 Activation of RAS in B cells Kras Rasgrp1 Hras Nras Rasgrp3 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1%REACTOME DATABASE ID RELEASE 66%10145226 SCF-beta-TrCP mediated degradation of Emi1 Psmc6 Psmb10 G6pc Psmb8 Psmb9 Psmb4 Psmb11 Psmb5 Psmf1 Psmb6 Cdc20 Psmd4 Psmb2 Cul1 Psmd5 Psmd8 Psmb7 Psmd9 Psmb1 Psmb3 Psma8 Skp1 Psmd11 Psmd12 Psmd13 Psmd14 Fzr1 Fbxo5 Psma5 Btrc Psma2 Psmc3 Psmc5 Psmd2 Psma1 Psma4 Psmc1 Psma3 Psmc4 Psmc2 Psma6 Psme1 Psmd1 Psme2 Psmd7 Psmd3 Psmd6 ETHANOL OXIDATION%REACTOME DATABASE ID RELEASE 66%10144819 Ethanol oxidation Adh4 Acss2 Adh6 Adh7 Aldh2 Aldh1b1 Acss1 RHO GTPASES REGULATE CFTR TRAFFICKING%REACTOME DATABASE ID RELEASE 66%10146090 RHO GTPases regulate CFTR trafficking Rhoq FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF)%REACTOME DATABASE ID RELEASE 66%10146023 Formation of Senescence-Associated Heterochromatin Foci (SAHF) Asf1a Ubn1 Cabin1 LOC100911837 Hira GOLGI-TO-ER RETROGRADE TRANSPORT%REACTOME%R-RNO-8856688.1 Golgi-to-ER retrograde transport Kif21a Kif21b Kifc1 Kif3c Racgap1 Pla2g6 Klc1 Arf5 Kif22 Dync1li2 Kif3b Copa Kif23 Kif18b Kifap3 Kif11 Kif12 Kif4a Kif6 Kif1a Kif1c Dync1i2 Arf4 Gbf1 Klc4 Kif27 Kif9 Cenpe Kif13b Klc2 Klc3 Pafah1b1 Kif3a LOC102555167 Dynll2 Dync1i1 Copz2 Copz1 Tmed7 Tmed3 Tmed2 Rab6b Napg Napb Napa Copb1 Rab3gap2 Tmed9 Bicd2 Nsf Bicd1 Kdelr1 Agpat3 Capza2 Capza3 Rab6a Arcn1 Kif20b Kif16b Kif26a Kif20a Kif26b Kif19 Kdelr2 Galnt1 Pafah1b3 Kdelr3 Galnt2 Bnip1 Use1 Rab18 Pla2g4a Actr10 Stx18 Dync1h1 Dync1li1 Copg1 Dctn5 Dctn6 Rab1b Rab1a Dctn4 Nbas Dctn1 Arfgap2 Dctn2 Arfgap3 Dctn3 Arfgap1 Kif2a Kif2c Kif2b Kif18a Capzb Kif5b Kif5a Sec22b Cope Actr1a Zw10 LOC100363782 Tmed10 REGULATION OF TP53 ACTIVITY THROUGH METHYLATION%REACTOME DATABASE ID RELEASE 66%10146002 Regulation of TP53 Activity through Methylation LOC100909949 Mdm2 Smyd2 LOC100910954 Mdm4 Chek2 Ehmt2 Ehmt1 Prmt5 Setd8 L3mbtl1 Ttc5 Atm RESPIRATORY ELECTRON TRANSPORT%REACTOME%R-RNO-611105.1 Respiratory electron transport Ndufab1 Mt-nd4 Ndufa7l Mt-nd5 Etfa Ndufaf7 Etfb Ndufa7 LOC683884 Ndufaf5 Mt-nd6 Nubpl Mt-nd2 LOC100911483 Ndufb10 Ndufb11 Ndufa12 Ndufa11 Ndufa13 Ndufa10 Ndufb6 Ndufb3 LOC100912599 Ndufb5 LOC100361505 Ndufc2 Ndufb9 Ndufb4 Ndufb8 Ndufb7 Ndufaf3 Ndufaf1 Ndufa2 Ndufa5 Ndufaf4 Ndufa6 RGD1306782 Ndufa1 Ndufs3 Ndufs1 Ndufs4 Ndufs5 Ndufs2 Ndufs8 Coq10a Ndufs6 Ndufs7 Timmdc1 LOC684509 Acad9 Ndufb2 LOC679739 Etfdh LOC679195 LOC100910710 LOC680288 Ecsit LOC688963 Tmem126b LOC100363268 Ndufv3 LOC100361144 Ndufv1 Ndufv2 REVERSIBLE HYDRATION OF CARBON DIOXIDE%REACTOME%R-RNO-1475029.1 Reversible hydration of carbon dioxide Car6 Car13 Car12 Car3 Car7 Car9 Car5a Car14 Car5b Car2 Car1 SENSING OF DNA DOUBLE STRAND BREAKS%REACTOME%R-RNO-5693548.1 Sensing of DNA Double Strand Breaks LOC100359600 Nbn Rad50 Atm Mre11a Kpna2 NOSIP MEDIATED ENOS TRAFFICKING%REACTOME DATABASE ID RELEASE 66%10145408 NOSIP mediated eNOS trafficking Nosip Nos3 BIOSYNTHESIS OF PROTECTIN AND RESOLVIN CONJUGATES IN TISSUE REGENERATION (PCTR AND RCTR)%REACTOME%R-RNO-9026766.1 Biosynthesis of protectin and resolvin conjugates in tissue regeneration (PCTR and RCTR) Ltc4s COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES%REACTOME%R-RNO-1650814.1 Collagen biosynthesis and modifying enzymes Col19a1 Pcolce Col22a1 Col16a1 Col5a2 Col5a1 Col4a5 Col9a1 Col27a1 Col9a2 Col9a3 Col4a1 Col5a3 Bmp1 Col4a2 Col4a3 Crtap Col7a1 Col23a1 Col6a5 Col6a6 Col20a1 P4ha1 P4ha2 P4ha3 LOC100910835 Col13a1 LOC100910384 Adamts3 Serpinh1 Col8a1 Col8a2 Col3a1 Col28a1 Col1a1 Col1a2 Ppib Col6a1 Col6a2 Col18a1 P4hb Adamts14 Tll2 Col11a2 Col11a1 Tll1 LOC100911572 P3h3 Colgalt2 Col26a1 Col14a1 Plod2 Plod1 Colgalt1 LOC102555086 Plod3 Col17a1 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6%REACTOME%R-RNO-69017.1 CDK-mediated phosphorylation and removal of Cdc6 Psmc6 Psmb10 Psmb8 Psmb9 Psmb4 Psmb11 Psmb5 Psmf1 Psmb6 Psmd4 Psmb2 Psmd5 Psmd8 Psmd9 Psmb3 Psma8 Psmd11 Psmd12 Ccna2 Anapc11 Ccne2 Ccna1 Anapc15 Psmd13 Anapc10 Psmd14 Ccne1 Fzr1 Cdk2 Psmc3 Cdc6 G6pc Ube2d1 Psmb7 Psmb1 Anapc7 Cdc26 Cdc27 Psma5 Cdc23 Ube2c Anapc16 Cdc16 Anapc4 Psma2 Anapc2 Anapc1 Psmc5 Psmd2 Psma1 Psma4 Psmc1 Psma3 Psmc4 Psmc2 Psma6 Psme1 Psmd1 Psme2 Psmd7 Psmd3 Psmd6 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24-HYDROXYCHOLESTEROL%REACTOME%R-RNO-193775.1 Synthesis of bile acids and bile salts via 24-hydroxycholesterol Amacr Akr1d1 Cyp39a1 Ptgis Akr1c2 Akr1c3 Akr1c12l1 Slc27a2 Cyp46a1 Cyp8b1 Akr1c19 Slc27a5 Akr1c13 Akr1c14 RGD1564865 Hsd3b7 Akr1c12 Akr1c1 RUNX3 REGULATES CDKN1A TRANSCRIPTION%REACTOME%R-RNO-8941855.1 RUNX3 regulates CDKN1A transcription Smad3 LOC100910954 Tgfb1 Zfhx3 INTERLEUKIN-6 FAMILY SIGNALING%REACTOME%R-RNO-6783589.1 Interleukin-6 family signaling Stat1 Crlf1 Cntfr Jak1 Lif Il6 Il6st Osm Stat3 Cbl Il11ra1 Lifr Socs3 Clcf1 Ptpn11 Il11 Il31ra Ctf1 Cntf Osmr Tyk2 NA+ CL- DEPENDENT NEUROTRANSMITTER TRANSPORTERS%REACTOME%R-RNO-442660.1 Na+ Cl- dependent neurotransmitter transporters Slc6a11 Slc6a13 Slc6a1 Slc6a12 Slc6a2 Slc18a1 Slc22a1 Slc6a15 Slc22a2 Slc6a7 Slc6a14 Slc6a19 Slc6a18 Slc6a9 Slc6a3 Slc6a20 Slc6a6 Slc6a5 REGULATION OF MITOTIC CELL CYCLE%REACTOME%R-RNO-453276.1 Regulation of mitotic cell cycle Psmc6 Psmb10 Psmb8 Psmb9 Psmb4 Psmb11 Bub3 Psmb5 Psmf1 Psmb6 Psmd4 Psmb2 Cul1 Psmd5 Psmd8 Psmd9 Psmb3 Psma8 Psmd11 Psmd12 Ccna2 Anapc11 Ccna1 Anapc15 Aurka Psmd13 Psmd14 Anapc10 Fzr1 Fbxo5 Cdk2 Aurkb Psmc3 G6pc Ube2d1 Cdc20 Psmb7 Psmb1 Bub1b Skp1 Mad2l1 Anapc7 Cdc26 Cdc14a Cdc27 Cdc23 Psma5 Pttg1 Ube2c Skp2 Cdkn1a Cdkn1b Cdk1 Anapc16 Cdc16 Nek2l1 Btrc Anapc4 Anapc2 Psma2 Anapc1 Psmc5 Psmd2 Psma1 Psma4 Psmc1 Psma3 Psmc4 Psmc2 Psma6 Psme1 Nek2 Psmd1 Psme2 Psmd7 Psmd3 Psmd6 ERKS ARE INACTIVATED%REACTOME DATABASE ID RELEASE 66%10145380 ERKs are inactivated Ppp2cb Dusp3 Ppp2ca LOC100912585 Mapk7 Ppp2r1a Dusp4 Dusp7 Dusp6 Ppp2r1b Mapk1 Vrk3 PRE-NOTCH TRANSCRIPTION AND TRANSLATION%REACTOME DATABASE ID RELEASE 66%10146305 Pre-NOTCH Transcription and Translation Prkci Elf3 VITAMIN B2 (RIBOFLAVIN) METABOLISM%REACTOME DATABASE ID RELEASE 66%10145350 Vitamin B2 (riboflavin) metabolism Rfk Flad1 Enpp1 RGD1563242 Acp5 Slc52a2 Slc52a3 STABILIZATION OF P53%REACTOME%R-RNO-69541.1 Stabilization of p53 Psmc6 Psmb10 Mdm2 G6pc Psmb8 Psmb9 Psmb4 Psmb11 Psmb5 Psmf1 Psmb6 Psmd4 Psmb2 Psmd5 Psmd8 Psmb7 Psmd9 Psmb1 Psmb3 Psma8 Psmd11 Psmd12 Psmd13 Psmd14 Phf20 Atm Psma5 LOC100910954 Mdm4 Chek2 Psma2 Psmc3 Psmc5 Psmd2 Psma1 Psma4 Psmc1 Psma3 Psmc4 Psmc2 Psma6 Psme1 Psmd1 Psme2 Psmd7 Psmd3 Rfwd2 Psmd6 RESPONSE TO METAL IONS%REACTOME DATABASE ID RELEASE 66%10146118 Response to metal ions Mt3 HYALURONAN METABOLISM%REACTOME%R-RNO-2142845.1 Hyaluronan metabolism Cd44 Hexb Lyve1 Stab2 Hexa Has1 Has2 Slc9a1 Gusb Hyal1 Hyal2 Chp1 Cemip ACTIVATION OF NA-PERMEABLE KAINATE RECEPTORS%REACTOME%R-RNO-451307.1 Activation of Na-permeable kainate receptors Grik1 Grik2 ELEVATION OF CYTOSOLIC CA2+ LEVELS%REACTOME%R-RNO-139853.1 Elevation of cytosolic Ca2+ levels P2rx2 P2rx3 P2rx1 Itpr1 P2rx5 P2rx6 Itpr3 P2rx4 Trpc3 Trpc7 Trpc6 P2rx7 TRANSLESION SYNTHESIS BY POLI%REACTOME DATABASE ID RELEASE 66%10146112 Translesion synthesis by POLI Rfc1 Rfc2 Rpa3 Pcna Poli Rev1 Rpa1 Rpa2 Mad2l2 Rfc5 Rev3l Rfc4 Rfc3 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES)%REACTOME DATABASE ID RELEASE 66%10145812 Cross-presentation of soluble exogenous antigens (endosomes) Psmc6 Psmb10 G6pc Psmb8 Psmb9 Psmb4 Psmb11 Psmb5 Psmf1 Psmb6 Psmd4 Psmb2 Psmd5 Psmd8 Psmb7 Psmd9 Psmb1 Psmb3 Psma8 Psmd11 Psmd12 Mrc2 Psmd13 Mrc1 Psmd14 Fcgr1a Psma5 Cd207 Psma2 Psmc3 Psmc5 Psma1 Psmd2 Psma4 Psmc1 Psma3 Psmc4 Psmc2 Psma6 Psme1 Psmd1 Psme2 Psmd7 Psmd3 Psmd6 GALACTOSE CATABOLISM%REACTOME DATABASE ID RELEASE 66%10144777 Galactose catabolism Gale Pgm2l1 Galk1 Pgm2 Pgm1 Galt ERK MAPK TARGETS%REACTOME DATABASE ID RELEASE 66%10145363 ERK MAPK targets Dusp3 Mapk7 Dusp4 Ppp2r1b Mapk1 Vrk3 Rps6ka2 Rps6ka1 Rps6ka3 Ppp2cb Rps6ka5 Ppp2ca LOC100912585 Ppp2r1a Dusp7 Dusp6 Mapk14 Mapk11 TRANSPORT OF GAMMA-CARBOXYLATED PROTEIN PRECURSORS FROM THE ENDOPLASMIC RETICULUM TO THE GOLGI APPARATUS%REACTOME%R-RNO-159763.1 Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus Pros1 Proz Bglap F2 F7 F9 Gas6 FORMATION OF TC-NER PRE-INCISION COMPLEX%REACTOME DATABASE ID RELEASE 66%10146151 Formation of TC-NER Pre-Incision Complex Gtf2h1 Gtf2h2 Usp7 Ppie Ddb1 Mnat1 Rbx1 RGD1565904 Isy1 Polr2g Polr2h Polr2e Polr2f Polr2j Polr2k Polr2d Polr2i Polr2b Polr2c Polr2a Xab2 Cops8 LOC100912534 Cops2 Zfp830 Prpf19 Tcea1 Cul4b Uvssa Ccnh Cul4a Hmgn1 Xpa Gtf2h3 Gtf2h5 Gtf2h4 Ercc8 Ercc3 Ercc6 LOC100911295 LOC100911822 Cops4 Aqr Cops6 Ercc2 Cops3 Cdk7 Cops7b Cops7a EICOSANOIDS%REACTOME%R-RNO-211979.1 Eicosanoids Cyp4a2 Cyp4f39 LOC100912391 Tbxas1 Cyp4a1 Ptgis Cyp4f17 Cyp4f6 Cyp4a8 Cyp8b1 Cyp4f18 MRNA CAPPING%REACTOME DATABASE ID RELEASE 66%10144929 mRNA Capping Gtf2h1 Gtf2h2 Mnat1 RGD1565904 Ercc3 Polr2g Polr2h Polr2e Polr2f Polr2j Polr2k Polr2d Supt5h LOC100911822 Polr2i Polr2b Polr2c Ercc2 Polr2a Rnmt Rngtt Ncbp2 Gtf2f1 LOC100912534 Gtf2f2 Ncbp1 Cdk7 Ccnh Gtf2h3 Gtf2h5 Gtf2h4 MITOTIC SPINDLE CHECKPOINT%REACTOME DATABASE ID RELEASE 66%10145064 Mitotic Spindle Checkpoint Cenpn Zwilch Cenpl Cenpo Nup43 Nup133 Dync1li2 Cenpt Cenpu Bub3 Bub1 Spdl1 Kntc1 Dync1i2 Mad1l1 Cenpk Cenph Cenpi Nup37 Cenpf Cenpe Cenpm Ahctf1 Ndel1 Rcc2 Pafah1b1 Mis12 Dynll2 Ndc80 Cenpc Cenpa Dync1i1 Ranbp2 Birc5 Taok1 Ube2d1 Ppp2cb Ppp2ca Ppp2r1a Nup85 Anapc7 Cdc26 Cdc27 Cdc23 Ube2c Ppp2r1b Anapc16 Cdc16 Anapc4 Anapc2 Anapc1 Nup98 Nup107 Anapc11 Anapc15 Anapc10 Cdca8 Dync1h1 Dync1li1 Rangap1 Ppp1cc LOC100909468 Aurkb Sec13 Xpo1 LOC100911204 Spc24 Spc25 Itgb3bp Sgol2 Ppp2r5e Incenp Nsl1 B9d2 Cdc20 Kif2a Kif2c Kif2b Bub1b Kif18a Ppp2r5c Ppp2r5a Ppp2r5b Zwint Dsn1 Mad2l1 Casc5 Clasp2 Ercc6l Nuf2 Clasp1 LOC679582 Mapre1 Pmf1 Ckap5 Ska2 Sgol1 Zw10 Ska1 SYNTHESIS OF HEPOXILINS (HX) AND TRIOXILINS (TRX)%REACTOME%R-RNO-2142696.1 Synthesis of Hepoxilins (HX) and Trioxilins (TrX) Alox12 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME%R-RNO-69613.1 p53-Independent G1 S DNA damage checkpoint Psmc6 Psmb10 G6pc Psmb8 Psmb9 Psmb4 Psmb11 Psmb5 Psmf1 Psmb6 Psmd4 Psmb2 Psmd5 Psmd8 Psmb7 Psmd9 Psmb1 Psmb3 Psma8 Psmd11 Psmd12 Psmd13 Psmd14 Psma5 Chek2 Psma2 Psmc5 Psmc3 Psma1 Psmd2 Psma4 Psmc1 Cdc25a Psma3 Psmc4 Psmc2 Psma6 Psme1 Psmd1 Psme2 Psmd7 Psmd3 Psmd6 SHC1 EVENTS IN ERBB2 SIGNALING%REACTOME DATABASE ID RELEASE 66%10145824 SHC1 events in ERBB2 signaling Prkcd Ereg Nrg1 Btc LOC102552659 Erbb3 Erbb2 Nrg3 Egfr Hbegf Nrg4 Prkca Erbb4 Ptpn12 Shc1 Nrg2 ACTIVATION OF MATRIX METALLOPROTEINASES%REACTOME%R-RNO-1592389.1 Activation of Matrix Metalloproteinases Mmp8 Elane Mmp15 Mmp17 Mmp7 Mmp11 Mmp14 Mmp9 Try4 Mmp13 Mmp1 LOC103690254 Mmp2 Klkb1 Try10 LOC100365995 Ctsg Ctsl Timp2 Timp1 Ctsk Cma1 LOC683849 Furin Col18a1 Tpsb2 LOC102554637 Spock3 Prss2 Tpsab1 Mmp24 Ctrb1 Plg Mmp16 Prss1 Mmp10 TANDEM OF PORE DOMAIN IN A WEAK INWARDLY RECTIFYING K+ CHANNELS (TWIK)%REACTOME DATABASE ID RELEASE 66%10145844 Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK) Kcnk1 LOC100909725 Kcnk6 Kcnk7 FRUCTOSE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 66%10146095 Fructose biosynthesis Akr1b1 Sord TRANSLOCATION OF ZAP-70 TO IMMUNOLOGICAL SYNAPSE%REACTOME DATABASE ID RELEASE 66%10145399 Translocation of ZAP-70 to Immunological synapse Cd3g Cd247 Cd3e RT1-Ba Cd3d RT1-Bb RT1-Da RT1-Db2 Cd4 Ptpn22 RT1-Db1 LOC688090 BIOSYNTHESIS OF DPAN-3-DERIVED PROTECTINS AND RESOLVINS%REACTOME%R-RNO-9026286.1 Biosynthesis of DPAn-3-derived protectins and resolvins Alox5 Alox15 REGULATION OF APOPTOSIS%REACTOME DATABASE ID RELEASE 66%10146243 Regulation of Apoptosis Oma1 Opa1 SYNTHESIS OF (16-20)-HYDROXYEICOSATETRAENOIC ACIDS (HETE)%REACTOME%R-RNO-2142816.1 Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) Cyp2c7 Cyp4a2 Cyp1b1 LOC100361547 Cyp4a1 Cyp1a1 Cyp2u1 Cyp1a2 Cyp4a8 Cyp2c6v1 KERATAN SULFATE KERATIN METABOLISM%REACTOME DATABASE ID RELEASE 66%10145729 Keratan sulfate keratin metabolism Hexb Kera Hexa Lum Prelp Chst5 LOC100911750 Chst2 Chst1 B3gnt4 B3gnt7 B3gnt1 B3gnt2 B3gnt3 Fmod Acan Omd Glb1l LOC100910891 B4galt1 Ogn B4galt3 Slc35d2 B4galt2 Glb1 B4galt6 St3gal2 B4galt4 St3gal3 B4galt5 St3gal1 St3gal4 St3gal6 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A%REACTOME DATABASE ID RELEASE 66%10145216 Cdc20:Phospho-APC C mediated degradation of Cyclin A Psmc6 Psmb10 Psmb8 Psmb9 Psmb4 Psmb11 Bub3 Psmb5 Psmf1 Psmb6 Psmd4 Psmb2 Psmd5 Psmd8 Psmd9 Psmb3 Psma8 Psmd11 Psmd12 Anapc11 Ccna2 Ccna1 Anapc15 Psmd13 Anapc10 Psmd14 Psmc3 G6pc Ube2d1 Cdc20 Psmb7 Psmb1 Bub1b Mad2l1 Anapc7 Cdc26 Cdc27 Cdc23 Psma5 Ube2c Cdk1 Anapc16 Cdc16 Anapc4 Psma2 Anapc2 Anapc1 Psmc5 Psmd2 Psma1 Psma4 Psmc1 Psma3 Psmc4 Psmc2 Psma6 Psme1 Psmd1 Psme2 Psmd7 Psmd3 Psmd6 LDL CLEARANCE%REACTOME%R-RNO-8964038.1 LDL clearance Ap2a2 Pcsk9 Npc1 Nceh1 Lipa Soat1 Soat2 Cltc Ldlr Clta Apob Ap2s1 Ldlrap1 Ap2a1 Ap2m1 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX%REACTOME%R-RNO-445989.1 TAK1 activates NFkB by phosphorylation and activation of IKKs complex Ripk2 Ager Nfkbib Traf6 App Tab1 Rela Map3k7 Irak2 Nfkb2 Nfkb1 S100b Dhx9 Chuk Nkiras1 LOC100362142 Nod1 Nod2 Nfkbia Nkiras2 LOC100910771 Ube2n Tab2 Tab3 LOC100912618 Ube2v1 Ikbkb Myd88 CHEMOKINE RECEPTORS BIND CHEMOKINES%REACTOME%R-RNO-380108.1 Chemokine receptors bind chemokines Ccl21 Ccr6 Ccr5 Pf4 Ccr4 Ccr3 Ccl27 Ccl20 Ccl25 Cxcl12 Xcr1 Cxcl16 Ccr10 Cx3cr1 Ccl19 Ccr7 Ackr4 Ccr8 Ackr3 Cxcr3 Cxcl10 Cxcr4 Xcl1 Ccr9 Cxcl9 Cxcl11 Cxcl6 Cx3cl1 Cxcl2 Cxcl1 Cxcl3 Ccl5 Ppbp Cxcr5 Ccrl2 Cxcr6 Cxcr2 Ccl1 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL%REACTOME%R-RNO-198323.1 AKT phosphorylates targets in the cytosol Akt3 Mdm2 Cdkn1a Akt1s1 Cdkn1b Chuk Tsc2 Akt1 Akt2 Casp9 PROCESSING OF DNA DOUBLE-STRAND BREAK ENDS%REACTOME DATABASE ID RELEASE 66%10146130 Processing of DNA double-strand break ends Rhno1 Rfc2 Bard1 Wrn Topbp1 Rbbp8 Rmi1 Rmi2 Hus1 Rad50 Ppp4r2 Ppp4c Rpa1 Rpa2 Ccna2 Ccna1 Atm Atrip Cdk2 Rpa3 Rad1 Brca1 Atr Blm Rad17 Slc25a16 Sirt6 Rfc5 Rfc4 Rad9a Nbn Rfc3 Rad9b Mre11a CARGO TRAFFICKING TO THE PERICILIARY MEMBRANE%REACTOME DATABASE ID RELEASE 66%10146079 Cargo trafficking to the periciliary membrane Arf4 Sstr3 Inpp5e Bbs7 Bbs5 Bbs4 Rab8a Gbf1 Exoc3 Exoc2 Exoc1 Exoc6 Exoc5 Exoc8 Exoc7 Ttc8 Pde6d Bbs9 Bbs1 Bbs2 Rab11a Smo Mchr1 Arl6 Rab3ip Lztfl1 Pkd2 Pkd1 Cnga4 Cnga2 Cngb1 Arl13b GLYCEROPHOSPHOLIPID BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 66%10144908 Glycerophospholipid biosynthesis Pla2g6 Pla2g3 Pla2g5 Pitpnb Pla2g16 Pla2g15 Pla2g10 Csnk2a2 LOC103689982 Osbpl5 Cpne3 Pla2g12a Osbpl8 Csnk2a1 Stard7 Fam73b Awat2 Lpcat4 Alpp Lpcat1 Alpi Plbd1 Abhd4 Lipi Cpne6 Acp6 Lpcat3 Lpcat2 Cpne1 Cpne7 Gnpat Agk Abhd3 Tmem86b Lclat1 Bche Pla2g4cl1 Chat Etnppl Ache Cept1 Pld2 Pld6 Alppl2 Dgat2l6 Agpat1 Agpat4 Ptdss2 Agpat3 Cdipt Pnpla8 Agpat9 Dgat1 Agpat6 LOC317456 Agpat5 Etnk1 Osbpl10 Pnpla3 Gpam Pnpla2 Crls1 Lpin2 Lpin3 Lpin1 Dgat2 Gpat2 Gpd2 Cds2 Ddhd2 Ddhd1 Pla2r1 Slc44a4 Pld1 Pla2g4e Slc44a5 Pla2g4b Mboat1 Pla2g4d Slc44a3 Mboat7 Pctp Pla2g4a LOC100910990 Cds1 Pla2g4c Taz Mgll Hrasls5 Slc44a2 Pcyt1b Pcyt1a Pitpnm1 Pitpnm3 Pitpnm2 Rbm12 Stard10 Pcyt2 Pla2g2a Pla2g2f Pla2g2d Gpd1l Pla2g1b LOC686302 LOC100911615 Chka Mfsd2a Csnk2b Phospho1 Lpgat1 Hadha Hadhb Gpd1 Agpat2 Pemt NEUROPHILIN INTERACTIONS WITH VEGF AND VEGFR%REACTOME%R-RNO-194306.1 Neurophilin interactions with VEGF and VEGFR LOC100911280 Kdr Flt1 Nrp1 Nrp2 DNA REPLICATION PRE-INITIATION%REACTOME DATABASE ID RELEASE 66%10144714 DNA Replication Pre-Initiation Psmc6 Psmb10 Psmb8 Pole2 Psmb9 Pole4 Psmb4 Psmb11 Psmb5 Psmf1 Psmb6 Psmd4 Psmb2 Psmd5 Psmd8 Psmd9 Psmb3 Psma8 Psmd11 Psmd12 Prim2 Pola2 Psmd13 Psmd14 Prim1 Mcm2 Mcm4 Mcm3 Cdk2 Mcm5 Rpa3 Mcm6 Pole Mcm10 Psmc3 Mcm8 Mcm7 Orc4 Orc5 Orc6 Orc1 Orc2 Orc3 Cdc7 Cdc6 Cdc45 Gmnn G6pc E2f2 Psmb7 Psmb1 Rpa1 Rpa2 E2f1 Psma5 E2f3 Cdt1 Psma2 Psmc5 Psmd2 Psma1 Psma4 Psmc1 Psma3 Psmc4 Psmc2 Psma6 Psme1 Psmd1 Psme2 Psmd7 Psmd3 Psmd6 PRESYNAPTIC FUNCTION OF KAINATE RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145706 Presynaptic function of Kainate receptors Plcb1 Grik3 Gnb3 Gnb5 Plcb3 Gnb2 Gnb1 Gng13 Gng12 Gng11 LOC100912034 Gnb4 Gng4 Gngt2 Gng5 Gngt1 Gng10 Gng8 Gng3 NADPH REGENERATION%REACTOME DATABASE ID RELEASE 66%10145547 NADPH regeneration Idh1 KERATAN SULFATE DEGRADATION%REACTOME%R-RNO-2022857.1 Keratan sulfate degradation Prelp Ogn Glb1 Hexb Kera Hexa Omd Glb1l Lum LOC100910891 Acan Fmod BIOSYNTHESIS OF D-SERIES RESOLVINS%REACTOME DATABASE ID RELEASE 66%10146303 Biosynthesis of D-series resolvins Hpgd Gpx4 Alox5 Lta4h AMPLIFICATION OF SIGNAL FROM THE KINETOCHORES%REACTOME%R-RNO-141424.1 Amplification of signal from the kinetochores Cenpn Zwilch Cenpl Nup43 Cenpo Nup98 Nup133 Dync1li2 Nup107 Cenpt Cenpu Bub3 Bub1 Spdl1 Kntc1 Dync1i2 Mad1l1 Cenpk Cenph Nup37 Cenpi Cenpf Cenpe Cenpm Ahctf1 Ndel1 Cdca8 Dync1h1 Rcc2 Pafah1b1 Dync1li1 Rangap1 Mis12 Ppp1cc LOC100909468 Aurkb Dynll2 Ndc80 Sec13 Cenpc Xpo1 Cenpa Dync1i1 LOC100911204 Ranbp2 Spc24 Spc25 Birc5 Taok1 Itgb3bp Sgol2 Ppp2r5e Incenp Nsl1 B9d2 Cdc20 Kif2a Kif2c Kif2b Bub1b Kif18a Ppp2r5c Ppp2cb Ppp2r5a Ppp2ca Ppp2r1a Ppp2r5b Zwint Dsn1 Mad2l1 Nup85 Casc5 Clasp2 Ercc6l Nuf2 Clasp1 LOC679582 Ppp2r1b Mapre1 Pmf1 Ckap5 Ska2 Sgol1 Zw10 Ska1 REGULATION OF INSULIN SECRETION%REACTOME DATABASE ID RELEASE 66%10145114 Regulation of insulin secretion Plcb1 Cacna1e Slc25a5 Marcks Plcb3 Ffar1 Gnaq Gna11 Gna14 Gna15 Adcy5 Adcy6 Kcnj11 Abcc8 Gng10 Cacna1c Cacna1d Slc2a2 Adra2a Gnai2 Adra2c Gnb3 Rap1a Gnb5 Kcnc2 Gnb2 Gnb1 Gng13 Gng12 Gng11 Prkaca Prkacb Itpr1 Cacnb2 Kcns3 Rapgef4 Itpr3 Prkca LOC100912034 Slc2a1 Gnb4 Glp1r Gcg Cacna2d2 Gng4 Gngt2 Gnai1 Gng5 Gngt1 Gng8 Gng3 INTERLEUKIN-23 SIGNALING%REACTOME%R-RNO-9020933.1 Interleukin-23 signaling Il12rb1 P4hb Il23a Il12b Stat3 Il23r Tyk2 CALCINEURIN ACTIVATES NFAT%REACTOME DATABASE ID RELEASE 66%10145926 Calcineurin activates NFAT RGD1560225 Ppp3ca Nfatc2 Ppp3r1 Nfatc3 RNA POLYMERASE I TRANSCRIPTION%REACTOME%R-RNO-73864.1 RNA Polymerase I Transcription Gtf2h1 Gtf2h2 Mnat1 RGD1565904 Ubtf Polr1b Taf1d Taf1c Polr2h Cd3eap Polr2e Znrd1 Polr2f Polr1c Polr2k Polr1a Ptrf Ttf1 Hist1h2bo Hist1h2bcl1 Hist2h3c2 LOC100912534 Rrn3 Hist1h2bk H3f3b Hdac2 Mbd3 Hdac1l Chd3 Chd4 Ccnh Mta3 Gtf2h3 Mta1 Mta2 Gatad2a Gtf2h5 Tbp Gtf2h4 Gatad2b LOC100910200 H2afx Hist1h4b LOC684841 Hist1h2bh LOC100912290 Rbbp7 Hist1h2ail1 Hist1h4m LOC102549173 LOC103690002 Ehmt2 LOC100910152 LOC100912338 Hist1h3c Hdac1 Ercc3 H2afb3 Hist1h3f Ercc6 Hist2h4 LOC684819 Hist1h3a H2afj Hist2h2aa3 Hist1h2bq Hist2h2aa2 Ercc2 LOC100364835 LOC684762 Cdk7 Twistnb Polr1e Hist1h2bg Mbd2 LOC680097 LOC684797 LOC100912418 Hist1h2ba Hist3h2bb LOC100910121 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS%REACTOME%R-RNO-75876.1 Synthesis of very long-chain fatty acyl-CoAs Acsl1 Acsl6 Acsl5 Acsl4 Tecr Hacd1 Tecrl LOC100365676 Hsd17b3 Acsbg1 Elovl1 Elovl5 Elovl2 Elovl3 Acsf3 Hacd4 Hacd3 Elovl6 Hsd17b12 Acsbg2 Acsl3 REGULATION OF COMPLEMENT CASCADE%REACTOME%R-RNO-977606.1 Regulation of Complement cascade C1s Elane C1r C1qb C4a C1qa C4b LOC100909666 LOC102549354 C2 Vtn C5ar1 Cd59 Cpn1 Cpn2 Cr2 Cpb2 Clu C5ar2 Cd46 Serping1 C6 Cfhr1 Cd19 C8g C3 RGD1564614 Cd81 C8a C8b Cfh F2 C3ar1 MTORC1-MEDIATED SIGNALLING%REACTOME%R-RNO-166208.1 mTORC1-mediated signalling LOC100912571 Eif4ebp1 Akt1s1 LOC100911431 Eef2k RragB Eif4g1 Lamtor3 Ywhab Eif4b Rps6kb1 Mtor Rheb Lamtor2 Rptor Lamtor1 Lamtor4 Lamtor5 Mlst8 LOC100911372 Rraga Rragc Rragd Rps6 Slc38a9 LOC680559 METABOLISM OF POLYAMINES%REACTOME%R-RNO-351202.1 Metabolism of polyamines Slc6a11 Smox Nqo1 Psmc6 Oaz3 Sat1 Slc6a12 RGD1564480 Psmb10 Oaz1 Oaz2 Psmb8 Psmb9 Psmb4 Psmb11 Psmb5 Psmf1 Psmb6 Psmd4 Psmb2 Psmd5 Psmd8 Psmd9 Psmb3 Azin1 Psma8 Psmd11 Psmd12 Slc6a7 Psmd13 Psmd14 Nmral1 Ass1 Nags Cps1 Slc25a2 Psmc3 Paox G6pc Otc Arg1 Psmb7 Psmb1 Agmat Psma5 Ckb Sms Enoph1 LOC100912604 Mtap Ckmt1b Mri1 Amd1 Gamt Adi1 Psma2 LOC100364487 Srm Psmc5 Psmd2 Psma1 Psma4 Psmc1 Psma3 Psmc4 Psmc2 Psma6 Psme1 Odc1 Psmd1 Psme2 Psmd7 Psmd3 Psmd6 G2 M CHECKPOINTS%REACTOME DATABASE ID RELEASE 66%10144759 G2 M Checkpoints Rhno1 Bard1 Psmc6 Rfc2 Wrn Topbp1 Psmb10 Rbbp8 Rmi1 Rmi2 Psmb8 Psmb9 Psmb4 Psmb11 Psmb5 Psmf1 Psmb6 Rad50 Bre Psmd4 Psmb2 Psmd5 Psmd8 Psmd9 Psmb3 Brcc3 Psma8 Psmd11 Psmd12 Pias4 Psmd13 Psmd14 Uimc1 Atm Mcm2 Atrip Mcm4 Mcm3 Cdk2 Mcm5 Sumo1 Clspn Rpa3 Mcm6 Mcm10 Rad1 Psmc3 Brca1 Atr Blm Mcm8 Mdc1 Mcm7 Ube2v2 Rad17 Orc4 Orc5 Ube2n Orc6 Orc1 Orc2 Orc3 Cdc7 Rfc5 Rad9a Rfc4 Cdc6 Rfc3 Nbn Rad9b Mre11a Cdc45 Hus1 Babam1 Tp53bp1 Herc2 Rpa1 Ywhah Rpa2 Ywhag Sfn Ywhaz Ywhab Ywhaq Ywhae Slc25a16 Hist1h2bo Hist1h2bcl1 Hist1h2bk Cdc25c Whsc1 LOC100910200 H2afx Hist1h4b Rnf8 G6pc Hist1h2bh LOC100912290 LOC686349 Hist1h4m Psmb7 LOC100912338 Psmb1 Hist2h4 Hist1h2bq LOC100364835 Psma5 Fam175a LOC100910954 Cdk1 Chek2 Psma2 Psmc5 Gtse1 Psma1 Psmd2 Psma4 Psmc1 Psma3 Wee1 Psmc4 Pkmyt1 Psma6 Psmc2 Psme1 Hist1h2bg Psme2 Psmd1 Psmd7 LOC680097 LOC684797 LOC100912418 Hist1h2ba Hist3h2bb Psmd3 Psmd6 ORGANIC CATION TRANSPORT%REACTOME%R-RNO-549127.1 Organic cation transport Slc22a1 Slc22a15 Slc22a2 Slc22a3 Runx1 Slc22a5 TRANSCRIPTIONAL ACTIVATION OF P53 RESPONSIVE GENES%REACTOME DATABASE ID RELEASE 66%10146178 Transcriptional activation of p53 responsive genes Zfp385a LOC100910954 CREATION OF C4 AND C2 ACTIVATORS%REACTOME DATABASE ID RELEASE 66%10145209 Creation of C4 and C2 activators C1s C1r Masp2 C1qb Colec10 C1qa Colec11 GLUCOSE METABOLISM%REACTOME%R-RNO-70326.1 Glucose metabolism Nup93 Nup43 Nup98 Nup133 LOC100911625 Mdh2 Nup107 Mdh1 Eno3 Aaas Gapdhs Eno1 Eno2 Nup210 Aldoa Npap60 Got1 Fbp1 Nup35 Aldob Fbp2 Aldoc Nup37 Nupl2 Gckr Nupl1 Pklr Pc Got2 Pfkfb3 Pfkfb4 Pfkfb1 Pfkfb2 Pfkl Pfkp Nup205 Aldoart2 Ranbp2 Slc25a11 Slc25a10 Hk2 Pgm2l1 G6pc Nup155 Tpi1 Gpi Nup88 Slc25a1 Nup85 Pgk2 G6pc3 Pgk1 Nup153 Slc37a2 Pkm Tpr Pgam1 Pgam2 Rae1 Gnpda2 Adpgk Pck1 Nup54 Pom121 Bpgm Nup62 Slc37a1 INTERLEUKIN-27 SIGNALING%REACTOME%R-RNO-9020956.1 Interleukin-27 signaling Canx Stat1 Crlf1 Il6st Jak1 Stat3 Tyk2 Ebi3 Il27ra TRANSCRIPTIONAL REGULATION BY THE AP-2 (TFAP2) FAMILY OF TRANSCRIPTION FACTORS%REACTOME%R-RNO-8864260.1 Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors Cited1 Atad2 Sumo1 Tfap2b Tfap2c Bmyc Cited2 Tfap2d Tfap2a Tfap2e Lhb Esr1 Cited4 Yeats4 Ube2i Crebbp Cga Dek TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION)%REACTOME%R-RNO-2173791.1 TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) Arhgef18 Pard6a Rhoa Smurf1 Tgfbr1 Pard3 Tgfb1 F11r Prkcz Tgfbr2 Cgn NEGATIVE REGULATION OF TCF-DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS%REACTOME DATABASE ID RELEASE 66%10146021 Negative regulation of TCF-dependent signaling by WNT ligand antagonists Lrp5 Lrp6 Dkk1 Kremen2 Sost Dkk2 Dkk4 BETA OXIDATION OF OCTANOYL-COA TO HEXANOYL-COA%REACTOME DATABASE ID RELEASE 66%10144937 Beta oxidation of octanoyl-CoA to hexanoyl-CoA LOC100911186 Echs1 Hadh Hadha Hadhb Acadm RAB REGULATION OF TRAFFICKING%REACTOME DATABASE ID RELEASE 66%10146223 Rab regulation of trafficking Trappc10 Rabgap1 Madd Sbf1 Rin3 Rab35 Rab18 Rgp1 Rab8a Ulk1 Sbf2 Rab10 Rab14 Rab27a Trappc2l Gapvd1 Rab21 Dennd3 Tbc1d10a Trappc6a Trappc6b Tbc1d10b Arf6 Rab12 Rab3ip Rab13 LOC102555167 Hps4 Rab32 Gdi2 Rab39a Hps1 Mon1b Mon1a Rab38 Rab11b Rab1b Rab1a Tbc1d2 Dennd1a Tbc1d7 Gabarap Trappc12 Trappc11 Akt2 Rab4a Dennd1b Trappc2 Trappc5 Rab6b Rab9a Rab27b Ric1 Rab3a Akt1 Ccz1b St5 Rab7a Rab3gap2 Dennd6b Dennd6a Ywhae Trappc3 Rab8b Dennd5a LOC100910318 Gabarapl2 Rab3il1 Tsc1 Chm Trappc8 Rab11a Dennd4a Rab6a Dennd4b Tsc2 Rab7b Tbc1d13 Akt3 Tbc1d16 Tbc1d15 Tbc1d17 Sytl1 Dennd2a Rab33a Dennd2d Rab33b Dennd2c Trappc13 Tbc1d25 Rab9b Optn Tbc1d10c LOC100363782 Trappc1 Tbc1d14 NEUREXINS AND NEUROLIGINS%REACTOME%R-RNO-6794361.1 Neurexins and neuroligins Dlgap2 Dlgap3 Dlgap4 Grm1 Epb4.1l5 Lrrtm2 Lrrtm3 Lrrtm4 LRRTM1 Dlg2 Dlg3 Dlgap1 Epb4.1 Nrxn2 Shank1 Shank2 Dbnl Nlgn1 Homer3 Nlgn2 Nlgn3 Homer2 Homer1 Dlg4 Epb41l2 Epb41l3 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS%REACTOME%R-RNO-2029480.1 Fcgamma receptor (FCGR) dependent phagocytosis Pla2g6 Pld1 Abi1 Myo1c Abi2 Potef Rac1 Myh9 Nck1 Arpc1b LOC100909750 Cyfip1 Actb Fyn Brk1 Pld4 Ppapdc1a LOC103692716 Pld3 Baiap2 Limk1 Nf2 Ppapdc1b Pak1 Wasl Nckap1l Ptk2 Actg1 Cyfip2 Nckap1 Abl1 Fcgr3a Prkcd Wasf1 Arpc4 Src LOC100909609 Pik3r1 Pld2 Pik3r2 Arpc3 Hsp90ab1 Nckipsd LOC100361457 Myo9b Vav2 Vav1 Actr3 Fcgr1a Was Cd247 Actr2 Fgr Myo10 Vav3 Crk Mapk1 Cdc42 LOC100911597 Pik3cb Cd3g Arpc5 Plcg1 Lyn Dock1 Fcgr2b Wipf1 LOC103693683 Yes1 Wipf2 Elmo2 Wipf3 Hck Fcgr2a Syk Grb2 ENDOGENOUS STEROLS%REACTOME DATABASE ID RELEASE 66%10145314 Endogenous sterols Nr1h4 Cyp1b1 Cyp39a1 Pomc Ptgis Ncoa2 Cyp7a1 Arnt Cyp21a1 Rxra Fdxr Cyp51 Cyp46a1 Fdx1 Cyp8b1 Arnt2 Cyp19a1 Fdx1l Cyp4v3 Cyp7b1 Ncoa1 Ahr Cyp11b2 SPRY REGULATION OF FGF SIGNALING%REACTOME DATABASE ID RELEASE 66%10145760 Spry regulation of FGF signaling Mknk1 Ptpn11 Src Ppp2cb Ppp2ca Ppp2r1a Cbl Spry2 Mapk1 Grb2 ER-PHAGOSOME PATHWAY%REACTOME DATABASE ID RELEASE 66%10145816 ER-Phagosome pathway RT1-CE2 RT1-CE3 RT1-CE4 RT1-CE7 RT1-CE5 RT1-CE10 RT1-A Calr RT1-A2 RT1-M3-1 RT1-A1 Sec22b Tap1 B2m Tap2 RT1-M6-1 LOC683761 LOC100364956 Vamp8 RT1-M2 RT1-M6-2 LOC100364500 RT1-M5 RT1-M4 Tapbp Stx4 RT1-S3 Vamp3 OTHER SEMAPHORIN INTERACTIONS%REACTOME%R-RNO-416700.1 Other semaphorin interactions Trem2 Ptprc Plxna1 Sema4d Sema7a Tyrobp Cd72 Plxnd1 Sema6d Sema3e Sema5a SIGNALING BY BMP%REACTOME DATABASE ID RELEASE 66%10145385 Signaling by BMP Fstl1 Grem2 Amhr2 Smurf1 Cer1 Nog Ube2d1 Acvrl1 Bmp2 Amh Acvr2a Chrdl1 Smad9 Smad5 Smad6 Ube2d3 Gdf2 Bmpr2 Zfyve16 NEGATIVE REGULATION OF FGFR2 SIGNALING%REACTOME DATABASE ID RELEASE 66%10145762 Negative regulation of FGFR2 signaling Src Fgf23 Fgf22 Fgf4 Fgf1 Fgf3 Ppp2cb Ppp2ca Fgf6 Fgf5 Ppp2r1a Fgf20 Mknk1 Fgf16 Fgf17 Fgf10 Fgf9 Fgfr2 Fgf7 Fgf2 Fgf8 Spry2 Cbl Mapk1 Ptpn11 Frs2 Grb2 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF)%REACTOME DATABASE ID RELEASE 66%10145896 Regulation of cholesterol biosynthesis by SREBP (SREBF) Kpnb1 Mbtps1 Mbtps2 RGD1306195 Srebf1 Scap Srebf2 APOPTOSIS%REACTOME DATABASE ID RELEASE 66%10144862 Apoptosis Faslg Appl1 Kpnb1 Cflar Fadd Apc Dsg3 Dsg2 Sptan1 Dffa Kpna1 LOC100911856 Diablo Casp3 Hmgb2 RGD1559962 Ripk1 LOC100360940 Tradd Tnfsf10 Fas Clspn Prkcq Dnm1l Plec Dynll2 Vim Nmt1 Fnta Ptk2 Satb1 Gzmbl1 Prkcd Bmx Gzmc LOC100911163 Gzmbl2 Rock1 Birc2 Gzmbl3 Bak1 Dcc Lmna Gzmb LOC691695 Ywhah Mapt Bcl2l11 Ywhag Casp6 Stk26 Sfn Add1 Stk24 Ywhaz Acin1 Ppp3r1 Bcl2 Gas2 Ocln Bid Ywhab Xiap Tjp2 Bcap31 Ywhaq Ywhae Dsp Cdh1 Casp8 Bad Dsg1 Casp9 Mapk8 Gsn Lmnb1 Pkp1 Traf2 Bax Oma1 Dbnl Opa1 Bmf Pmaip1 DERMATAN SULFATE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 66%10145924 Dermatan sulfate biosynthesis Bcan Ncan Vcan LOC102550316 Cspg5 Dse Cspg4 LOC100910284 Ust Dcn Chst14 Dsel CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION%REACTOME DATABASE ID RELEASE 66%10144735 Cyclin E associated events during G1 S transition Psmc6 Psmb10 Psmb8 Psmb9 Psmb4 Psmb5 Psmf1 Psmb6 Psmd4 Mnat1 Psmb2 Cul1 Psmd5 Ptk6 Psmd8 Psmd9 Psmb3 Psmd11 Psmd12 Ccna2 Ccne2 Ccna1 Psmd13 Psmd14 Ccne1 Cdk2 Cks1l Cables1 Psmc3 Ccnh Cks1b Akt2 G6pc Rb1 Cdk4 Akt1 Psmb7 Psmb1 Ccnd1 Skp1 Psma5 Skp2 Cdkn1a Cdk7 Cdkn1b Psma2 Psmc5 Akt3 Psmd2 Psma1 Psma4 Psmc1 Cdc25a Wee1 Psma3 Psmc4 Psmc2 Psma6 Psme1 Psmd1 Psme2 Psmd7 Psmd3 Psmd6 BIOGENIC AMINES ARE OXIDATIVELY DEAMINATED TO ALDEHYDES BY MAOA AND MAOB%REACTOME DATABASE ID RELEASE 66%10145055 Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB Maob Maoa TNF SIGNALING%REACTOME%R-RNO-75893.1 TNF signaling Nsmaf Usp21 Fadd Birc3 Birc2 Adam17 Cyld Otud7b Madd Tax1bp1 Sppl2a Tab1 Clip3 Ripk1 Otulin Tradd Tnf Xiap Map3k7 Casp8 Tnfaip3 Rnf31 Sharpin Usp2 Traf1 Bag4 Rbck1 Smpd2 Smpd3 Chuk Traf2 Usp4 LOC100910771 Tab2 Tab3 Ikbkb DIGESTION OF DIETARY CARBOHYDRATE%REACTOME%R-RNO-189085.1 Digestion of dietary carbohydrate Amy2a3 Chia RGD1309110 Chit1 Amy1a Lct Si Chi3l3 PLATELET DEGRANULATION%REACTOME DATABASE ID RELEASE 66%10145469 Platelet degranulation Tex264 F13a1 Ola1 Psap Ly6g6f Ctsw Selp Serpina4 Pcyox1l Tor4a Islr Cdc37l1 Chid1 Fam3c Lhfpl2 Nhlrc2 Itih4 Mmrn1 Rarres2 Itih3 Lefty2 Ecm1 Serpine1 Anxa5 Tagln2 Gtpbp2 Timp3 Lefty1 LOC100910414 Lamp2 Plek Sccpdh Phactr2 Cfd Cd9 Kng1l1 A1bg Tgfb2 F8 Tgfb1 Tgfb3 Pf4 Aplp2 Cd109 Figf Rab27b Vegfc Vegfb Brpf3 Apoa1 Pdgfa Pdgfb Timp1 Abcc4 A2m Tln1 Vwf Actn4 Vegfa Habp4 Pcdh7 Apool Apoh Plg Wdr1 Srgn LOC100911881 Lgals3bp Sytl4 LOC100912012 Serpina3m Fermt3 Cyb5r1 Maged2 Vcl Sparc Sod1 Actn2 Gas6 Aldoa App Tf Flna Igf2 Igf1 Clu Serping1 Cd63 Fgb RGD1565355 Fgg Hgf Thbs1 Fga Aldoart2 Actn1 Qsox1 LOC685953 Cd36 Scg3 Stxbp2 Kng1 LOC299277 Kng2 Fn1 Ppbp Tuba4a Pros1 Itga2b PROGRAMMED CELL DEATH%REACTOME%R-RNO-5357801.1 Programmed Cell Death Faslg Appl1 Kpnb1 Cflar Fadd Apc Dsg3 Dsg2 Mlkl Sptan1 Ripk3 Dffa Kpna1 LOC100911856 Diablo Casp3 Hmgb2 RGD1559962 Ripk1 LOC100360940 Tradd Tnfsf10 Fas Clspn Prkcq Dnm1l Plec Dynll2 Vim Nmt1 Fnta Ptk2 Satb1 Gzmbl1 Prkcd Bmx Gzmc LOC100911163 Gzmbl2 Rock1 Birc3 Birc2 Gzmbl3 Bak1 Dcc Lmna Gzmb LOC691695 Ywhah Mapt Bcl2l11 Ywhag Casp6 Stk26 Sfn Add1 Stk24 Ywhaz Acin1 Ppp3r1 Bcl2 Gas2 Ocln Bid Ywhab Xiap Tjp2 Bcap31 Ywhaq Ywhae Dsp Cdh1 Casp8 Bad Dsg1 Casp9 Mapk8 Gsn Lmnb1 Pkp1 Traf2 Bax Oma1 Dbnl Opa1 Bmf Pmaip1 SIGNALING BY NOTCH2%REACTOME DATABASE ID RELEASE 66%10145921 Signaling by NOTCH2 Notch2 Mdk Dll4 Maml1 Rbpj Rbpjl2 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS)%REACTOME DATABASE ID RELEASE 66%10145487 Class A 1 (Rhodopsin-like receptors) Gpr39 Ffar1 Ptgir Kng1l1 Cmklr1 Gpr35 Ccr6 Pomc Chrm4 Oxtr Oxt LOC100909648 Avpr1b Avpr1a Opn1sw Oprl1 Ccl21 Prokr2 Mc3r Ccr5 Gal Ccr4 Ccr3 Gpr37 Ccl27 Cckar Gper1 Ccl20 Uts2r Prokr1 Ccl25 NMS Xcr1 Cxcl16 Pdyn Prlhr Ccr10 Gpr37l1 Ccl19 Ccr7 Ccr8 Cxcr3 Cxcl10 Ccr9 Opn1mw Cxcl11 Ece2 Ece1 Xk Sstr5 Brs3 Npbwr1 Pyy C5ar2 Pnoc Ccl5 Npy2r Mc4r Prok2 Oprm1 Prok1 Mchr1 Sstr1 Aplnr Sstr4 Sstr2 Cck Npy1r Apln Tacr3 Tacr2 Bdkrb1 Bdkrb2 Rln3 Npb Ppy Trh Ccl1 Npw Mc2r Npy Nps Adra1a Tbxa2r Sstr3 Penk Adra1d C5ar1 Kng1 Kng2 Gphb5 Gnrhr Gpha2 Gnrh1 Htr4 Fshr Tshr Cxcr5 Htr7 Uts2b Npy5r Nmur2 Cxcr6 Oprd1 Lhcgr LOC100909513 LOC100360745 Htr6 Npff Npffr2 RGD1560028 Psap Hcrt Npffr1 Qrfp LOC100909783 Lhb Oxgr1 Ptgdr Ptgdr2 Sucnr1 Adra2b Adrb3 F2rl3 Hcrtr1 F2r Qrfpr Cxcr2 F2 Hcrtr2 Ptger2 Tshb Cga F2rl2 Hebp1 Uts2 Fpr-rs6 Ntsr2 Trhr Nmu Fpr-rs3 Pf4 Mc5r Fpr2 Fpr3 Ntsr1 Anxa1 Pmch Rxfp1 Htr2c Rxfp2 Htr2a Kel Fpr-rs4 Insl3 Tac3 Kiss1 Rxfp3 Tac1 Htr2b Lpar5 Edn2 S1pr1 Ednra S1pr5 Ptafr Ednrb S1pr4 Edn3 Grp S1pr3 Grpr Lpar1 Cx3cr1 Lpar3 Edn1 Lpar2 F2rl1 Sst Ackr4 S1pr2 Ackr3 Nmb Xcl1 Cxcl9 Cxcl6 Cx3cl1 Gpr31 Cxcl2 Taar9 Rgr Cxcl1 Gpr18 Gpr55 Gpr4 Hrh2 Htr5a Fshb Taar6 Cxcl3 Agt Gpr132 Taar5 Cnr2 Gpr143 Taar2 Opn3 Lppr1 Opn4 Cnr1 Lppr4 Htr1d Lppr5 Htr1f Lppr2 Htr1a Hrh1 Lppr3 Htr1b Hrh4 Chrm1 Ptger3 Chrm5 Adora3 Agtr2 Gpr183 Prlh Mtnr1a Opn5 Galr1 LOC100909523 Ccrl2 Hcar1 Nts Hcar2 Oprk1 Cysltr2 Adora2a Drd5 Cysltr1 Adora2b Drd1 Gpr65 Gpr68 LOC100911796 Drd4 Ptgfr LOC100363178 Drd2 Adora1 Ptger1 LOC100365814 Chrm3 Agtr1b Agtr1a Fpr1 Chrm2 Ltb4r Ffar2 Ffar3 Ltb4r2 Avp C3ar1 P2ry6 Lpar6 P2ry4 P2ry1 Gpr17 Lpar4 Ptgdrl Cxcl12 P2ry12 Cxcr4 P2ry2 P2ry10 P2ry13 Adra2a Adra2c C3 Ppbp Cckbr Adrb2 Tacr1 TELOMERE C-STRAND SYNTHESIS INITIATION%REACTOME DATABASE ID RELEASE 66%10145233 Telomere C-strand synthesis initiation Pole2 Pole4 Prim2 Pola2 Pole Prim1 DCC MEDIATED ATTRACTIVE SIGNALING%REACTOME%R-RNO-418885.1 DCC mediated attractive signaling Nck1 Src Fyn LOC100909609 Wasl Dock1 Ntn1 Ptk2 Dcc Rac1 Cdc42 THE FATTY ACID CYCLING MODEL%REACTOME DATABASE ID RELEASE 66%10145135 The fatty acid cycling model Ucp2 Ucp3 LOC100909612 Slc25a14 Ucp1 SYNTHESIS OF UDP-N-ACETYL-GLUCOSAMINE%REACTOME%R-RNO-446210.1 Synthesis of UDP-N-acetyl-glucosamine Renbp Gfpt2 Amdhd2 Pgm3 Nagk Gfpt1 Gnpnat1 Uap1 HYALURONAN BIOSYNTHESIS AND EXPORT%REACTOME%R-RNO-2142850.1 Hyaluronan biosynthesis and export Has1 Has2 Cemip SMOOTH MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 66%10145669 Smooth Muscle Contraction Dysf Myl10 Cav3 Myl7 Myh11 Tln1 Actg2 Pxn Sorbs3 Cald1 Trim72 Vcl Sorbs1 LOC102551071 Mylpf Pak2 Pak1 Tpm4 Tpm2 Mylk Tpm3 Myl12a DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX%REACTOME%R-RNO-195253.1 Degradation of beta-catenin by the destruction complex Ctbp2 Psmc6 Psmb10 Apc Psmb8 Psmb9 Psmb4 Psmb11 Psmb5 Psmf1 Psmb6 Psmd4 Psmb2 Rbx1 Cul1 Psmd5 Psmd8 Psmd9 Psmb3 Psma8 Psmd11 Psmd12 Psmd13 Psmd14 LOC100909468 Psmc3 Tle3 Peg12 Amer1 Csnk1a1 Frat2 Ppp2r5e G6pc Psmb7 Psmb1 Ppp2r5c Ppp2cb Ppp2r5a Ppp2ca Skp1 Ppp2r1a Ppp2r5b Psma5 Ppp2r1b Btrc Psma2 Psmc5 Psmd2 Psma1 Psma4 Psmc1 Psma3 Psmc4 Psmc2 Psma6 Psme1 Tcf7 Lef1 Psmd1 Psme2 Tcf7l1 Psmd7 Tle4 Tle1 Tle2 Psmd3 Psmd6 POLO-LIKE KINASE MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 66%10145073 Polo-like kinase mediated events Wee1 Pkmyt1 Cdc25c Foxm1 SYNTHESIS OF 12-EICOSATETRAENOIC ACID DERIVATIVES%REACTOME DATABASE ID RELEASE 66%10145948 Synthesis of 12-eicosatetraenoic acid derivatives Alox12 Gpx4 Alox15 Aloxe3 BETAKLOTHO-MEDIATED LIGAND BINDING%REACTOME%R-RNO-1307965.1 betaKlotho-mediated ligand binding Fgf19 Fgfr4 CYCLIN D ASSOCIATED EVENTS IN G1%REACTOME DATABASE ID RELEASE 66%10144736 Cyclin D associated events in G1 Ccnd3 Src Ppp2r3b Rb1 E2f2 Rbl1 Cdk4 Mnat1 Cul1 Ptk6 E2f4 Ppp2cb Ppp2ca Ccnd1 Skp1 Ppp2r1a Tfdp1 Tfdp2 Rbl2 LOC100909750 E2f1 E2f3 Cks1l Skp2 Cdkn1a Cdk7 Cdkn1b Ppp2r1b E2f5 Ccnh Cdkn2b Ppp2r2a Lyn Cdkn2c Cdk6 Cks1b Abl1 DNA DOUBLE-STRAND BREAK REPAIR%REACTOME DATABASE ID RELEASE 66%10144762 DNA Double-Strand Break Repair Rhno1 Rfc1 Rfc2 Bard1 Wrn Topbp1 Rbbp8 Rmi1 Rmi2 Pole2 Rad51c Pole4 LOC100911267 Polh Ppp5c Rad51d Spidr Rad51 Eme2 Eme1 Brca2 Polq Rad50 Rtel1 Bre Ppp4r2 Ppp4c Brcc3 Pias4 Ccna2 Ccna1 Uimc1 Atm Atrip LOC100909750 Cdk2 Sumo1 Rpa3 Lig3 Pole Pcna Xrcc3 Rad1 Brca1 Bap1 Atr Blm Slx4 Mdc1 Mus81 Ube2v2 Slx1b Rad17 Palb2 Sirt6 Ube2n Gen1 Ube2i Rfc5 Xrcc2 Rad9a Rfc4 Rfc3 Nbn Rad9b Mre11a LOC100359600 Hus1 Babam1 Tp53bp1 Rad52 Herc2 Xrcc4 Rpa1 Rpa2 Ercc1 Mapk8 Slc25a16 Fen1 Kpna2 Xrcc6 Xrcc5 Hist1h2bo Hist1h2bcl1 Hist1h2bk Kdm4b Kdm4a Smarca5 Abl1 Whsc1 LOC100910200 H2afx Hist1h4b Rnf8 Hist1h2bh Eya3 LOC100912290 Apbb1 Eya2 LOC686349 Eya4 Hist1h4m LOC100912338 Hist2h4 Hist1h2bq Baz1b LOC100364835 Xrcc1 Fam175a Parp2 Parp1 LOC100910954 Chek2 Pold2 Pold1 Pold4 Tdp2 Lig4 Paxip1 Polm Hist1h2bg Nhej1 Prkdc Dclre1c LOC680097 LOC684797 Poll LOC100912418 Hist1h2ba Hist3h2bb NICOTINATE METABOLISM%REACTOME%R-RNO-196807.1 Nicotinate metabolism Nnmt Nt5e Ptgis Apoa1bp Rnls Carkd Nampt Cd38 Parp14 Nudt12 Nmnat2 Nmnat1 Slc5a8 Nmrk1 Nmrk2 Nadsyn1 Cyp8b1 Parp9 Naprt1 Parp6 Bst1 Parp8 Qprt Ptgs2 Nadk ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS%REACTOME DATABASE ID RELEASE 66%10145788 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Blnk Pik3r1 Dapp1 Cd79al Pik3ap1 Stim1 Cd19 Itpr1 Nck1 Ptpn6 Itpr3 Sh3kbp1 Pik3cd Sos1 Vav1 Cd79b Cd22 Syk Cd79a Grb2 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION)%REACTOME%R-RNO-70614.1 Amino acid synthesis and interconversion (transamination) Serinc4 Psph Rimklb Serinc2 Gpt Serinc3 Srr Aspa Serinc1 Nat8l Naalad2 Folh1 Pycrl Aldh18a1 Got1 Oat Asns Pycr2 Psat1 Pycr1 Phgdh Glul Ccbl1 Got2 TRANSPORT OF ORGANIC ANIONS%REACTOME DATABASE ID RELEASE 66%10145337 Transport of organic anions Slco1a1 Slco4a1 Slco1a6 Slco1a4 Slco3a1 Slco1a2 Slco4c1 Slco2b1 Slco1b2 Slco2a1 Slc16a2 Slc21a4 Slco1c1 Avp NIK-->NONCANONICAL NF-KB SIGNALING%REACTOME DATABASE ID RELEASE 66%10146074 NIK-->noncanonical NF-kB signaling Psmc6 Psmb10 Psmb8 Psmb9 Psmb4 Psmb11 Psmb5 Psmf1 Psmb6 Psmd4 Cul1 Psmb2 Psmd5 Psmd8 Psmd9 Psmb3 Psma8 Psmd11 Psmd12 Psmd13 Psmd14 Ube2m Psmc3 G6pc Psmb7 Psmb1 Skp1 Nfkb2 Psma5 Fbxw11 Chuk Btrc Psma2 Psmc5 Psmd2 Uba3 Psma1 Map3k14 Psma4 Relb Psmc1 Psma3 Psmc4 Psmc2 Psma6 Psme1 Psmd1 Psme2 Psmd7 Psmd3 Psmd6 HISTAMINE RECEPTORS%REACTOME%R-RNO-390650.1 Histamine receptors Hrh4 Hrh2 Hrh1 SHC-MEDIATED CASCADE:FGFR4%REACTOME%R-RNO-5654719.1 SHC-mediated cascade:FGFR4 Kras Fgf16 Fgf17 Fgf9 Fgf2 Fgf8 Fgfr4 Fgf23 Fgf4 Fgf1 Fgf6 Fgf19 Hras Nras Sos1 Shc1 Fgf20 Grb2 APEX1-INDEPENDENT RESOLUTION OF AP SITES VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 66%10146092 APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway Neil1 Ogg1 Neil2 Xrcc1 Lig3 Pnkp Polb UNFOLDED PROTEIN RESPONSE (UPR)%REACTOME DATABASE ID RELEASE 66%10145530 Unfolded Protein Response (UPR) Mbtps1 Eif2ak3 Mbtps2 LOC100363239 Sec61g Ern1 LOC100361694 Creb3l3 Sec63 Crebrf Serp1 Creb3 Sec61a1 Sec62 Sec61a2 Sec61b Atf6 Asna1 Eif2s1 STIMULI-SENSING CHANNELS%REACTOME%R-RNO-2672351.1 Stimuli-sensing channels Scnn1b Best1 Best3 Best2 Trpc4ap Scnn1g Tpcn2 Scnn1a Clcn4 Raf1 Unc79 Sri Slc9b1 Clcn7 Clcn6 Clcn5 Ano10 Wwp1 Ano3 Clic2 Asic4 Asic5 Ano1 Trdn Best4 Clcnkb Asic3 Slc9b2 Trpm2 Slc17a3 Sgk2 Sgk3 Clcn1 LOC100912455 Wnk4 Ostm1 Wnk1 Wnk2 Wnk3 Vps25 Clcn2 Stom Clca4 Fkbp1b Trpv4 Trpv5 Trpv6 Ano9 Ryr2 Ano4 Ano7 Clca2 Sgk1 Stoml3 Mcoln2 Mcoln3 Trpv1 Trpc5 Trpm6 Ttyh1 Ano6 Trpm3 Ttyh2 Trpm8 LOC100361584 Trpm5 Trpc3 Trpc7 Trpm1 Trpc4 Bsnd Mcoln1 Trpc6 Trpv3 Trpa1 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS)%REACTOME DATABASE ID RELEASE 66%10144780 Glycogen breakdown (glycogenolysis) Phkb Phkg1 Gyg1 Pgm2l1 Gaa Agl Pgm2 Pygl Pgm1 Pygm Phkg2 Phka1 B CELL ACTIVATION%REACTOME DATABASE ID RELEASE 66%10145789 B Cell Activation Psmc6 Psmb10 Psmb8 Psmb9 Stim1 Psmb4 Nfkbib Psmb11 Psmb5 Psmf1 Psmb6 Psmd4 Psmb2 Cul1 Psmd5 Psmd8 Psmd9 Psmb3 Nck1 Psma8 Psmd11 Psmd12 Psmd13 Rela Psmd14 Cd22 Cd19 Psmc3 Nfkbia Sh3kbp1 Kras G6pc Pik3r1 Pik3ap1 Psmb7 Psmb1 Skp1 Prkcb Ppp3r1 Pik3cd Vav1 Cd79b Cd79a Nfkbie Nfkb1 Blnk Psma5 Dapp1 Cd79al Fbxw11 Rasgrp1 Chuk Rasgrp3 Btrc Psma2 RGD1560225 Psmc5 Ppp3ca Psma1 Psmd2 Itpr1 Psma4 Nfatc2 Psmc1 Psma3 Itpr3 Ptpn6 Psmc4 Psma6 Psmc2 Psme1 Lyn Hras Psmd1 Psme2 Nras Ikbkb Psmd7 Sos1 Nfatc3 Syk Psmd3 Grb2 Psmd6 PTK6 REGULATES RHO GTPASES, RAS GTPASE AND MAP KINASES%REACTOME DATABASE ID RELEASE 66%10146205 PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases Kras LOC100909609 Crk Pxn Bcar1 Rac1 Arhgap35 Ptk6 Rhoa Dock1 Hras Nras Elmo2 Rasa1 EPH-EPHRIN SIGNALING%REACTOME DATABASE ID RELEASE 66%10146025 EPH-Ephrin signaling Grin2b Grin1 Aph1b Psenen Mmp9 Aph1a LOC100911293 Psen2 Potef Psen1 Rac1 Mmp2 Ncstn Rock2 Sdc2 Arpc1b Actb Fyn Ephb1 Ephb2 Sdcbp LOC103692716 Pak2 Pak3 Pak1 Wasl Ephb4 Ephb3 Efnb2 Ptk2 Efnb1 Actg1 Efnb3 Myl12a Nck2 Arpc4 Arhgef7 Src Rock1 Arpc3 Itsn1 Epha10 Kalrn LOC100361457 LOC100912512 Vav2 Efna2 Actr3 Efna1 Efna4 Actr2 Kdr Tiam1 Vav3 Epha4 Epha5 Ngef Epha7 Cdc42 Epha8 Vegfa Epha3 Epha2 Epha1 Rhoa Arpc5 Lyn Hras Yes1 Rasa1 Shb Arhgef28 TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN CYTOCHROME C RELEASE%REACTOME%R-RNO-6803204.1 TP53 Regulates Transcription of Genes Involved in Cytochrome C Release Prelid1 Bnip3l Zfp420 Triap1 Slmo1 LOC100910137 Atm POLYMERASE SWITCHING%REACTOME DATABASE ID RELEASE 66%10144729 Polymerase switching Rfc1 Rfc2 Prim2 Pola2 Prim1 Rfc5 Rfc4 Pold2 Rfc3 Pcna Pold1 Pold4 PERK REGULATES GENE EXPRESSION%REACTOME DATABASE ID RELEASE 66%10145531 PERK regulates gene expression Eif2ak3 Eif2s1 REGULATION OF RUNX3 EXPRESSION AND ACTIVITY%REACTOME%R-RNO-8941858.1 Regulation of RUNX3 expression and activity Psmc6 Src Psmb10 Mdm2 G6pc Psmb8 Psmb9 Psmb4 Psmb5 Psmf1 Psmb6 Psmd4 Psmb2 Psmd5 Psmd8 Psmb7 Psmd9 Psmb1 Psmb3 Psmd11 Psmd12 Psmd13 Psmd14 Smurf1 Psma5 Psma2 Psmc5 Psmc3 Psma1 Psmd2 Psma4 Psmc1 Cbfb Psma3 Psmc4 Psmc2 Psma6 Psme1 Psmd1 Psme2 Psmd7 Tgfb1 Psmd3 Psmd6 LIGAND-RECEPTOR INTERACTIONS%REACTOME DATABASE ID RELEASE 66%10145666 Ligand-receptor interactions Gas1 Hhip Dhh Ihh Cdon Shh Ptch1 PLATELET HOMEOSTASIS%REACTOME DATABASE ID RELEASE 66%10145040 Platelet homeostasis Atp2b4 Atp2b2 Sri Atp2b1 Gnaq Gna11 Gna14 Gna15 Nos3 Pla2g4a Atp2a2 P2rx7 Atp2a3 Pde1b Pde3b P2rx1 Ptgir LOC497963 Slc8a3 Apob Slc8a2 Gng10 Slc8a1 Pde9a Pde5a Pde3a Pafah2 Prkg2 Pde2a Cyct Mrvi1 Pde10a Pde11a Nos1 Fgr Gnb3 Gnb5 Gnb2 Gnb1 Gng13 Gng12 Gng11 P2rx2 Lrp8 P2rx3 P2rx5 Itpr1 P2rx6 P2rx4 Itpr3 LOC100912034 Gnb4 Trpc3 Trpc7 Gng4 Gngt2 Mapk14 Gng5 Trpc6 Gngt1 Gng8 Gng3 CLASSICAL ANTIBODY-MEDIATED COMPLEMENT ACTIVATION%REACTOME%R-RNO-173623.1 Classical antibody-mediated complement activation C1s C1r C1qb C1qa ZINC TRANSPORTERS%REACTOME DATABASE ID RELEASE 66%10145654 Zinc transporters Slc30a5 Slc39a2 Slc30a6 Slc39a3 Slc30a8 Slc39a4 Slc39a14 Slc39a6 Slc39a7 Slc39a8 Slc30a1 TRANSCRIPTIONAL REGULATION BY SMALL RNAS%REACTOME DATABASE ID RELEASE 66%10146071 Transcriptional regulation by small RNAs Nup93 Nup43 Nup98 Nup133 Nup107 Aaas RGD1306195 RGD1565904 Nup210 Npap60 Polr2g Polr2h Nup35 Polr2e Polr2f Polr2j Nup37 Polr2k Nupl2 Polr2d Tnrc6a Polr2i Polr2b Polr2c Nupl1 Polr2a Hist1h2bo Hist1h2bcl1 Hist2h3c2 LOC100912534 Hist1h2bk H3f3b Nup205 Ranbp2 LOC100910200 H2afx Hist1h4b LOC684841 Hist1h2bh LOC100912290 Nup155 Hist1h2ail1 Hist1h4m LOC102549173 LOC103690002 LOC100910152 LOC100912338 Hist1h3c H2afb3 Hist1h3f Nup88 Hist2h4 LOC684819 Hist1h3a H2afj LOC100911822 Hist2h2aa3 Hist1h2bq Hist2h2aa2 Nup85 LOC100364835 LOC684762 Nup153 Ago2 Tpr Rae1 Nup54 Pom121 Hist1h2bg LOC680097 Nup62 LOC684797 LOC100912418 Hist1h2ba Hist3h2bb INTERFERON SIGNALING%REACTOME%R-RNO-913531.1 Interferon Signaling LOC100912571 Camk2g Irf3 Stat1 Jak1 Pde12 Stat2 Pias1 Ptpn1 Oasl Rnasel Abce1 Camk2d Camk2a Socs3 Uba7 Ube2l6 Eif4g1 Sumo1 Eif4g2 Eif4g3 Ptpn2 Flnb Isg15 Trim25 Eif2ak2 Ppm1b Ube2n Usp18 Eif4e3 Mx1 Eif4a2 Mx2 Eif4a1 Tyk2 LOC680559 Irf9 Prkcd Ifngr2 Eif4e2 Ifngr1 Arih1 Ddx58 LOC100911431 Ifng Socs1 Eif4a3 Ifnar2 Ifna5 Ifna4 Ptpn11 LOC100912356 LOC100911527 Ptpn6 Ifna11 LOC100912859 Ifnar1 Plcg1 RGD1560539 Ifna2 Ifnb1 LOC103690314 LOC100912314 Ifna16l1 RGD1565911 RGD1561827 IRS ACTIVATION%REACTOME DATABASE ID RELEASE 66%10144874 IRS activation Grb10 Insr Ins1 Irs2 Ins2 Irs1 BUTYROPHILIN (BTN) FAMILY INTERACTIONS%REACTOME%R-RNO-8851680.1 Butyrophilin (BTN) family interactions Btn1a1 LOC684480 Cd209a Btnl2 Xdh Cd209b Cd209e Btn2a2 Ppl Clec4m NUCLEOTIDE SALVAGE%REACTOME%R-RNO-8956321.1 Nucleotide salvage Cda Adal Pnp Uck1 Tymp Ampd3 Dck LOC100909857 Aprt Gmpr2 Uckl1 Tk2 Ampd1 Gmpr Hdhd1 Uck2 Upp1 Upp2 Tk1 Dguok Hprt1 Ada Ampd2 COENZYME A BIOSYNTHESIS%REACTOME%R-RNO-196783.1 Coenzyme A biosynthesis Pank4 Coasy Pank3 Pank2 Ppcs Pank1 LOC100362038 Ppcdc TRANSLESION SYNTHESIS BY POLK%REACTOME DATABASE ID RELEASE 66%10146111 Translesion synthesis by POLK Rfc1 Rfc2 Rev1 Rpa1 Rpa3 Rpa2 Mad2l2 Rfc5 Rev3l Rfc4 Rfc3 Pcna KERATINIZATION%REACTOME%R-RNO-6805567.1 Keratinization LOC100912586 LOC100363287 Krtap15-1 Tgm1 Krt10 LOC100910942 Krt13 LOC690386 Dsg4 Krt19 Klk8 Krt18 Dsg3 Krt15 Dsg2 Dsc3 Krt14 Ivl Krt17 Krt16 Spink5 RGD1561281 Dsc2 Krt33b Spink6 Krt33a LOC684499 LOC100910851 LOC100363184 LOC680396 Rptn LOC100911681 Krtap3-3 Krtap3-1 Lipk Lipm Krtap4-5 LOC100360690 Krt9 LOC689230 Krt7 Stfa2l1 Krtap4-7 Stfa2l3 Krt2 Stfa2l2 Krt8 LOC100910814 Krt4 Krtap4-13 LOC680160 Krtap11-1 LOC100363136 LOC100909618 LOC687631 Krtap12-2 LOC100365646 LOC689927 Krt75 Krtap8-1 Krt71 Krtap24-1 Krt77 Krt73 Krt72 Krtap1-1 Krt40 Krt76 Krtap1-3 Krtap13-2 Krtap27-1 Krtap1-5 Krtap14l Krt28 LOC100361664 Krt24 Krt23 Krt31 Krt25 Krt26 Krt27 LOC690460 Krt35 Krt34 Krt32 LOC690478 Krtap3-3l1 Krt39 Krt36 Jup Kb23 Krtap9-1 Krt81 Krt80 Krtap26-1 Krt82 Krt84 Krt83 Krt86 Dsp Krt85 Dsg1 RGD1565682 Pkp1 Pkp4 Pkp3 Sprr3 Klk12 Klk13 Klk14 Stfa3l1 Casp14 Stfa3 Evpl Csta LOC100911797 Ppl Perp Cela2a LOC100362978 MRNA 3'-END PROCESSING%REACTOME DATABASE ID RELEASE 66%10144830 mRNA 3'-end processing Thoc5 Rnps1 Thoc7 Thoc3 Thoc2 Thoc1 Magohb Wdr33 Rbm8a Pcf11 Fip1l1 Thoc6 Nudt21 Ddx39a Cstf2 Ddx39b Chtop U2af1l4 Cpsf7 Cpsf2 Cpsf3 Cpsf4 Cstf1 Cpsf1 Sarnp Slu7 Srsf3 Upf3b U2af2 Papola Srsf6 Srsf7 Srsf4 Srsf5 Srsf2 LOC679894 Srsf9 Dhx38 Clp1 Magoh Ncbp2 Srsf1 Poldip3 Ncbp1 Cstf2t Eif4a3 Fyttd1 Sympk LOC100910660 Srrm1 Cdc40 LOC361990 MITOCHONDRIAL BIOGENESIS%REACTOME DATABASE ID RELEASE 66%10145879 Mitochondrial biogenesis LOC100911417 Atp5f1 LOC500350 Sirt4 Sirt3 Atp5g3 Gabpb1 Acss2 Idh2 Atp5g2 Atp5l Atp5o Atp5h Mt-atp6 Atp5i Atp5j Atp5j2 Sod2 Atp5s Atp5e Atp5d Mt-atp8 Atp5b RIP-MEDIATED NFKB ACTIVATION VIA ZBP1%REACTOME%R-RNO-1810476.1 RIP-mediated NFkB activation via ZBP1 Nfkb2 Nfkb1 Ager S100b Dhx9 Nfkbib Chuk Nkiras1 App Nfkbia Nkiras2 Rela Ikbkb Myd88 TWIK-RELEATED ACID-SENSITIVE K+ CHANNEL (TASK)%REACTOME DATABASE ID RELEASE 66%10145845 TWIK-releated acid-sensitive K+ channel (TASK) Kcnk3 Kcnk9 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX%REACTOME DATABASE ID RELEASE 66%10144838 Formation of the ternary complex, and subsequently, the 43S complex Eif3l Eif2s3 Eif3m Eif3j Eif3k Rps20 Rps27l Eif3e Eif3f Eif3b Eif3a Eif3d Eif3c Rps16 LOC100360573 Eif2s1 Rps18 Eif2s2 LOC100360679 Rps15 Rps4x Rps3a LOC100359951 LOC100359593 LOC100359503 LOC100362640 Rps3 Rps15a Rps2 Rps13 Rps12 LOC100911372 LOC100361854 LOC684988 LOC103689992 Rps5 Rps7 Rps6 Eif3g Eif3h LOC100362830 Eif1ax LOC100363012 LOC100911110 LOC100362149 GLYCOGEN SYNTHESIS%REACTOME%R-RNO-3322077.1 Glycogen synthesis Epm2a Gys1 Gyg1 Pgm2l1 Gys2 Ugp2 Pgm2 Nhlrc1 Ppp1r3c Pgm1 IRAK1 RECRUITS IKK COMPLEX%REACTOME DATABASE ID RELEASE 66%10145768 IRAK1 recruits IKK complex LOC100362142 Ube2n LOC100912618 Peli3 Ube2v1 Chuk Ikbkb Peli2 Traf6 Peli1 G2 M DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 66%10144758 G2 M DNA damage checkpoint Rhno1 Rfc2 Bard1 Wrn Topbp1 Rbbp8 Rmi1 Rmi2 Bre Rad50 Brcc3 Pias4 Uimc1 Atm Hist1h2bo Hist1h2bcl1 Atrip Hist1h2bk Sumo1 Rpa3 Cdc25c Brca1 Rad1 Blm Atr Mdc1 Ube2v2 Rad17 Ube2n Rfc5 Rfc4 Rad9a Nbn Rfc3 Rad9b Mre11a Whsc1 LOC100910200 H2afx Hist1h4b Rnf8 Hist1h2bh LOC100912290 Hus1 Babam1 LOC686349 Tp53bp1 Hist1h4m LOC100912338 Herc2 Rpa1 Hist2h4 Ywhah Ywhag Rpa2 Sfn Ywhaz Hist1h2bq Ywhab Ywhaq Ywhae LOC100364835 Fam175a LOC100910954 Cdk1 Chek2 Wee1 Slc25a16 Hist1h2bg LOC680097 LOC684797 LOC100912418 Hist1h2ba Hist3h2bb SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%R-RNO-427359.1 SIRT1 negatively regulates rRNA expression LOC100910200 H2afx Hist1h4b LOC684841 Hist1h2bh LOC100912290 Hist1h2ail1 Hist1h4m LOC102549173 LOC103690002 LOC100910152 LOC100912338 Hist1h3c H2afb3 Hist1h3f Hist2h4 LOC684819 Hist1h3a H2afj Rrp8 Hist2h2aa3 Hist1h2bq Suv39h1 Hist2h2aa2 LOC100364835 LOC684762 Hist1h2bo Hist1h2bcl1 Hist2h3c2 Hist1h2bk H3f3b Hist1h2bg LOC680097 LOC684797 LOC100912418 Hist1h2ba Suv39h1l1 Hist3h2bb CONDENSATION OF PROMETAPHASE CHROMOSOMES%REACTOME DATABASE ID RELEASE 66%10145973 Condensation of Prometaphase Chromosomes Csnk2a2 Csnk2b Csnk2a1 Smc4 Ncapg Smc2 NEGATIVE REGULATION OF FGFR3 SIGNALING%REACTOME%R-RNO-5654732.1 Negative regulation of FGFR3 signaling Mknk1 Src Fgf16 Fgf17 Fgf9 Fgf2 Fgf8 Spry2 Cbl Fgfr3 Mapk1 Fgf23 Fgf4 Ptpn11 Fgf1 Ppp2cb Ppp2ca Ppp2r1a Fgf5 Frs2 Fgf20 Grb2 NEDDYLATION%REACTOME DATABASE ID RELEASE 66%10146142 Neddylation Ddb2 Vhl Asb18 Asb11 Ddb1 Asb12 Rbx1 Asb13 Asb14 Socs5 Asb10 Socs3 Keap1 Wdtc1 Asb15 Commd8 Asb17 Socs6 Asb16 Cops8 Cops2 Cul4b Cand1 Cul4a Birc5 Rfwd2 Nedd8 Ube2d1 Ercc8 LOC100911374 Dcaf11 Ube2d3 Cops4 Dcaf13 Cops6 Ankrd9 Dcaf10 Cops3 Fbxl22 Lrrc41 Skp2 Fbxw10 Fbxw12 Obsl1 Cul1 Commd9 Neurl2 Dcaf8 G6pc Klhl5 Dcaf4 Psmb7 Psmb1 LOC100910472 Klhl2 Fbxo2 Fbxo9 Fbxo7 Fbxo6 Psma5 Fbxo4 Cul9 Dcun1d2 Cops7b Ube2f Cops7a Psma2 Psmd2 Dcaf7 Commd3 Klhl9 Dcaf5 Psmc2 Dcaf6 Dda1 Psmd1 Lrr1 Psmd7 Psmd3 Psmd6 Psmc6 Psmb10 Psmb8 Psmb9 Ccdc22 Psmb4 Fbxl19 Psmb11 Psmb5 Psmf1 Fbxl12 Psmb6 Fbxl13 Psmd4 Fbxl16 Psmb2 Cish Fbxl15 Psmd5 Psmd8 Psmd9 Psmb3 Psma8 Psmd11 Ccnf Psmd12 Psmd13 Psmd14 Dtl Commd7 Commd2 Commd1 Tceb2 Tceb1 Cul2 Dcun1d5 Commd4 Hif1a Dcun1d4 Commd5 Dcun1d3 Commd6 Psmc3 Uchl3 Fem1b Fem1a Senp8 RGD1561252 Epas1 Hif3a Nae1 Fbxl4 Fbxl5 Fbxl8 Rbbp5 Kctd7 Rnf7 Fem1c Skp1 Kbtbd8 Kbtbd7 Kbtbd6 Kctd6 Fbxw11 Commd10 Btrc Gan Fbxl18 Fbxl7 Asb5 Asb6 Asb7 Klhl41 Asb1 Asb3 Asb8 Klhl42 Fbxo41 Ube2m Fbxo44 Fbxo40 Wsb2 Wsb1 Spsb3 Spsb2 Spsb1 Spsb4 Btbd1 Btbd6 Fbxo22 Wdr5 Klhl13 Rbbp7 Fbxo30 Fbxo31 Klhl11 Fbxo32 Fbxo21 Klhl20 Zbtb16 Klhl25 Klhl21 Klhl22 Fbxo10 Fbxo15 Tulp4 Fbxo11 Fbxw2 Psmc5 Uba3 Psma1 Fbxw9 Psma4 Nub1 Psmc1 Psma3 Fbxw5 Psmc4 Fbxw4 Psma6 Fbxw8 Psme1 Fbxw7 Psme2 LOC100909844 ORGANELLE BIOGENESIS AND MAINTENANCE%REACTOME DATABASE ID RELEASE 66%10145880 Organelle biogenesis and maintenance Atp5f1 Kif3c Kif3b Kifap3 Idh2 Arf4 Dync1i2 Nphp1 Cep57 Mt-atp6 Cep97 Rab8a B9d1 Cep162 LOC691918 Gbf1 Haus3 Ninl Akap9 Nphp4 Ccp110 Tmem216 Rpgrip1l Pafah1b1 Smo Wdr35 Kif3a Ift88 Dynll2 Cngb1 Inpp5e Tubb5 Ywhag Ppp2r1a Exoc3 Exoc2 Exoc1 Exoc6 Ywhae Exoc5 Exoc8 Exoc7 Nek2l1 Prkaca Nek2 Hdac6 Dync1h1 Ttc8 Bbs9 LOC103692716 Bbs1 Bbs2 Mchr1 Arl6 Rab3ip Lztfl1 Atp5j2 Trip11 Mt-atp8 Dctn1 Mks1 C2cd3 LOC500350 Cntrl Ift81 Dctn2 Sirt4 Cep76 Sirt3 Atp5g3 Sept2 Pcm1 Gabpb1 Acss2 Cep78 LOC100912537 Ttbk2 Mark4 B9d2 LOC100911033 Cep164 Dctn3 Cep41 Ofd1 Sclt1 Atp5g2 Sstr3 Tctn1 Sdccag8 Bbs7 Bbs5 Bbs4 Cep83 Prkar2b Cenpj Cep89 Plk4 Ift122 Sod2 Wdr19 Ttc21b Ahi1 LOC100911417 LOC100912076 Tubg2 Haus2 Ift46 Haus1 Ift43 Haus5 Alms1 Wdr60 Clasp1 Kif17 Haus4 Odf2 Tnpo1 Pde6d Tubb4a Cdk1 Iqcb1 Dynlrb2 Rab11a Ift74 Tmem67 Ttc26 Ssna1 Dynlrb1 Tubg1 Tcte3 Mapre1 Cep63 Atp5l Dync2li1 Csnk1d Atat1 Atp5o Pkd2 Cep131 Ift52 Atp5h Pkd1 Tuba4a Cep250 Hspb11 Atp5i Cnga4 Cep135 Ift57 Atp5j Cnga2 Csnk1e Traf3ip1 Cdk5rap2 Ckap5 Ift27 Kif24 Arl13b Pcnt Ift22 Cep72 Ift20 Sfi1 Atp5s Cluap1 Cep70 Atp5e Tctex1d1 Actr1a Atp5d Tctex1d2 LOC100911746 Ift140 Ttc30b Nedd1 Atp5b Ift80 Fbf1 P53-INDEPENDENT DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 66%10144753 p53-Independent DNA Damage Response Psmc6 Psmb10 G6pc Psmb8 Psmb9 Psmb4 Psmb11 Psmb5 Psmf1 Psmb6 Psmd4 Psmb2 Psmd5 Psmd8 Psmb7 Psmd9 Psmb1 Psmb3 Psma8 Psmd11 Psmd12 Psmd13 Psmd14 Psma5 Chek2 Psma2 Psmc5 Psmc3 Psma1 Psmd2 Psma4 Psmc1 Cdc25a Psma3 Psmc4 Psmc2 Psma6 Psme1 Psmd1 Psme2 Psmd7 Psmd3 Psmd6 TFAP2 (AP-2) FAMILY REGULATES TRANSCRIPTION OF CELL CYCLE FACTORS%REACTOME%R-RNO-8866911.1 TFAP2 (AP-2) family regulates transcription of cell cycle factors Tfap2c Bmyc REGULATION OF IFNG SIGNALING%REACTOME DATABASE ID RELEASE 66%10145739 Regulation of IFNG signaling Socs3 Ptpn2 Socs1 Stat1 Sumo1 Jak1 Ifngr2 Ifngr1 Pias1 Ifng FGFR1C LIGAND BINDING AND ACTIVATION%REACTOME%R-RNO-190373.1 FGFR1c ligand binding and activation Fgf23 Fgf4 Fgf1 Fgf17 Fgf6 Fgf5 Fgf9 Fgf2 Fgf8 Fgfr1 Fgf20 REGULATION OF RAS BY GAPS%REACTOME%R-RNO-5658442.1 Regulation of RAS by GAPs Psmc6 Psmb10 Psmb8 Psmb9 Psmb4 Psmb11 Psmb5 Psmf1 Psmb6 Psmd4 Psmb2 Psmd5 Psmd8 Psmd9 Psmb3 Psma8 Psmd11 Psmd12 Psmd13 Psmd14 Psmc3 Kras G6pc Psmb7 Psmb1 Rasal3 Psma5 Rasal1 Rasal2 Psma2 Psmc5 Rasa4 Psmd2 Psma1 Spred1 Psma4 Psmc1 Spred2 Psma3 Psmc4 Rasa2 Psmc2 Psma6 Rasa3 Psme1 Hras Psmd1 Psme2 Nras Psmd7 Nf1 Rasa1 Syngap1 Psmd3 Psmd6 RETROGRADE TRANSPORT AT THE TRANS-GOLGI-NETWORK%REACTOME%R-RNO-6811440.1 Retrograde transport at the Trans-Golgi-Network Vps53 Vps52 LOC100909548 Arfip2 Vps54 Rab6b Rab9a Napg Igf2r Ric1 Napb Napa Tgoln2 Rgp1 Nsf Stx16 Rab43 Cog4 Cog6 Arl1 Gcc1 Cog8 Golga1 Cog3 Golga4 Rhobtb3 Cog1 Cog2 Usp6nl Arfrp1 Rab6a Cog7 Scoc Stx6 M6pr Vamp4 Plin3 Vamp3 Rab9b Rabepk TRANSLOCATION OF SLC2A4 (GLUT4) TO THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 66%10145854 Translocation of SLC2A4 (GLUT4) to the plasma membrane Ywhah Ywhag Sfn Ywhaz Tbc1d1 Rala Ywhab Ywhaq Ywhae ACTIVATION OF NMDA RECEPTORS AND POSTSYNAPTIC EVENTS%REACTOME%R-RNO-442755.1 Activation of NMDA receptors and postsynaptic events Grin2d Rras Camk2g Grin2b Grin1 Nefl Rasgrf1 Gria3 Raf1 Dlg1 Gria4 Dlg2 Dlg3 Camk2d Actn2 Camk2a Rps6ka2 Rps6ka1 Lrrc7 Rps6ka3 Adcy3 Adcy8 Camkk1 Pdpk1 Mapk1 Creb1 Rps6ka6 Hras Camk4 Dlg4 INTERACTION WITH CUMULUS CELLS%REACTOME DATABASE ID RELEASE 66%10145974 Interaction With Cumulus Cells Spam1 Hyal5 INTERLEUKIN-9 SIGNALING%REACTOME%R-RNO-8985947.1 Interleukin-9 signaling Stat5a Jak3 Il2rg Stat1 Jak1 Stat3 Il9r Il9 SIGNALING BY NOTCH%REACTOME DATABASE ID RELEASE 66%10145914 Signaling by NOTCH Notch1 Dtx4 Dtx2 Tmed2 Aph1b Psenen Aph1a Dll4 Maml1 Notch4 Rbpj LOC100911293 Jag1 Egfr Psen2 Kat2a Notch3 Psen1 Ncstn Akt1 Rbpjl2 Prkci Ywhaz Elf3 Dtx1 Furin Ybx1 Snw1 Notch2 Mdk Crebbp SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE%REACTOME DATABASE ID RELEASE 66%10144727 Switching of origins to a post-replicative state Psmc6 Psmb10 Psmb8 Psmb9 Psmb4 Psmb11 Psmb5 Psmf1 Psmb6 Psmd4 Psmb2 Rbx1 Cul1 Psmd5 Psmd8 Psmd9 Psmb3 Psma8 Psmd11 Psmd12 Ccna2 Anapc11 Ccne2 Ccna1 Anapc15 Psmd13 Psmd14 Ccne1 Anapc10 Fzr1 Mcm2 Mcm4 Mcm3 Cdk2 Mcm5 Mcm6 Psmc3 Mcm8 Mcm7 Orc4 Orc5 Orc6 Orc1 Orc2 Orc3 Cdc6 G6pc Ube2d1 Psmb7 Psmb1 Skp1 Anapc7 Cdc26 Cdc27 Cdc23 Psma5 Ube2c Skp2 Anapc16 Cdt1 Cdc16 Anapc4 Psma2 Anapc2 Anapc1 Psmc5 Psmd2 Psma1 Psma4 Psmc1 Psma3 Psmc4 Psmc2 Psma6 Psme1 Psmd1 Psme2 Psmd7 Psmd3 Psmd6 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA-HYDROXYCHOLESTEROL%REACTOME DATABASE ID RELEASE 66%10145313 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol Nr1h4 Amacr Akr1d1 Ptgis Rxra Acot8 Hsd17b4 Slc27a5 Abcb11 Cyp7b1 Hsd3b7 Akr1c2 Ncoa2 Acox2 Akr1c3 Akr1c12l1 Cyp7a1 Slc27a2 Baat Cyp8b1 Akr1c19 Akr1c13 Akr1c14 RGD1564865 Akr1c12 Ncoa1 Akr1c1 SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 66%10145498 Semaphorin interactions Crmp1 Rras Plxna2 Rock1 Plxna1 LOC102552659 Sema7a Erbb2 LOC103692570 Hsp90ab1 Sema6d Nrp1 Cdk5r1 Rac1 Farp2 Cdk5 Sema5a Arhgap35 Trem2 Sema4d Plxnb1 Rock2 Tyrobp Arhgef11 Sema3a Sema3e Pip5k1c Ptprc Fyn Tln1 Cd72 LOC103692716 Limk1 Dpysl2 Dpysl5 Dpysl4 LOC100910964 Rhoa Fes Pak2 Pak3 Pak1 Rnd1 Plxnd1 Rhob Rhoc Dpysl3 CREATINE METABOLISM%REACTOME DATABASE ID RELEASE 66%10144813 Creatine metabolism Slc6a11 Slc6a12 Ckb Slc6a7 Ckmt1b Gamt PHOSPHORYLATION OF PROTEINS INVOLVED IN G1 S TRANSITION BY ACTIVE CYCLIN E:CDK2 COMPLEXES%REACTOME DATABASE ID RELEASE 66%10145275 Phosphorylation of proteins involved in G1 S transition by active Cyclin E:Cdk2 complexes Cdk2 Rb1 Ccne2 Ccne1 INTRINSIC PATHWAY OF FIBRIN CLOT FORMATION%REACTOME DATABASE ID RELEASE 66%10145080 Intrinsic Pathway of Fibrin Clot Formation A2m Serpine2 Serpind1 Serping1 Vwf Klkb1 Kng1l1 Gp1ba Serpinc1 Gp9 Gp5 Gp1bb LOC100911551 Kng1 Prcp F2 F8 F12 F11 F9 Serpina5 Kng2 C1qbp RUNX1 INTERACTS WITH CO-FACTORS WHOSE PRECISE EFFECT ON RUNX1 TARGETS IS NOT KNOWN%REACTOME%R-RNO-8939243.1 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Actl6b Smarce1 Pbrm1 Auts2 Pcgf5 Arid1b Arid1a Smarcd1 Csnk2a2 Smarcd2 Smarcd3 Hipk2 Csnk2a1 Phc1 Actl6a Phc2 Scmh1 Csnk2b Cbx4 Cbx2 Cbx8 Cbx6 Bmi1 Rnf2 Yaf2 Ring1 Smarca4 Smarca2 Phc3 Cbfb Arid2 Smarcc1 Smarcc2 Smarcb1 Runx1 SUMO IS TRANSFERRED FROM E1 TO E2 (UBE2I, UBC9)%REACTOME DATABASE ID RELEASE 66%10145988 SUMO is transferred from E1 to E2 (UBE2I, UBC9) Rwdd3 Sumo1 Sae1 Ube2i Uba2 VITAMIN D (CALCIFEROL) METABOLISM%REACTOME%R-RNO-196791.1 Vitamin D (calciferol) metabolism Cubn Cyp27b1 Cyp2r1 Cyp24a1 Vdr Lgmn Gc ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM%REACTOME%R-RNO-2046104.1 alpha-linolenic (omega3) and linoleic (omega6) acid metabolism Acsl1 Acaa1a Acot8 Fads1 Acaa1b Acox1 Elovl1 Elovl5 Hsd17b4 Elovl2 Elovl3 Abcd1 KERATAN SULFATE BIOSYNTHESIS%REACTOME%R-RNO-2022854.1 Keratan sulfate biosynthesis Kera Lum Prelp Chst5 LOC100911750 Chst2 Chst1 B3gnt4 B3gnt7 B3gnt1 B3gnt2 B3gnt3 Fmod Acan Omd LOC100910891 B4galt1 Ogn B4galt3 Slc35d2 B4galt2 B4galt6 St3gal2 St3gal3 B4galt4 B4galt5 St3gal1 St3gal4 St3gal6 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 66%10144723 Activation of the pre-replicative complex Gmnn Pole2 Pole4 Rpa1 Rpa2 Prim2 Pola2 Prim1 Mcm2 Mcm4 Mcm3 Cdk2 Mcm5 Rpa3 Mcm6 Mcm10 Pole Cdt1 Mcm8 Mcm7 Orc4 Orc5 Orc6 Orc1 Orc2 Orc3 Cdc7 Cdc6 Cdc45 HCN CHANNELS%REACTOME%R-RNO-1296061.1 HCN channels Hcn1 Hcn3 Hcn2 SUMOYLATION OF DNA REPLICATION PROTEINS%REACTOME%R-RNO-4615885.1 SUMOylation of DNA replication proteins Nup93 Nup43 Nup98 Nup133 Incenp Nup107 Top1 Pias3 Aaas Nup155 Nup210 Npap60 Nup35 Nup88 Nup37 Pias4 Nupl2 Nupl1 Nup85 Nup153 Cdca8 Sumo1 Tpr Rangap1 Sumo3 Rae1 Pcna Aurkb Nup54 Ube2i Pom121 Nup205 Ranbp2 Nup62 Birc5 HEDGEHOG 'ON' STATE%REACTOME%R-RNO-5632684.1 Hedgehog 'on' state Psmc6 Psmb10 Psmb8 Psmb9 Psmb4 Psmb11 Psmb5 Psmf1 Psmb6 Psmd4 Psmb2 Rbx1 Psmd5 Psmd8 Psmd9 Psmb3 Psma8 Psmd11 Psmd12 Psmd13 Psmd14 Rpgrip1l Smurf1 Smo Evc2 Kif3a Ift88 Psmc3 Mks1 Cdc73 Csnk1a1 RGD1564313 Dzip1 Sufu G6pc Dhh Cdon Shh Ptch1 Efcab7 Spop Iqce Spopl Ofd1 Ulk3 Psmb7 Boc Psmb1 Gli1 Gli3 Gli2 Ihh Evc RGD1559714 RGD1563667 Psma5 Psma2 Psmc5 Arrb1 Psma1 Psmd2 Ift52 Psma4 Kif7 Psmc1 Arrb2 Ift57 Psma3 Psmc4 Gas1 Psmc2 Hhip Psma6 Gas8 Psme1 LOC689173 Psmd1 Psme2 Adrbk1 Psmd7 Gpr161 Psmd3 Psmd6 FRS2-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 66%10145200 Frs2-mediated activation Ntrk1 Ngf Crkl Frs2 Rapgef1 LOC100911248 G BETA:GAMMA SIGNALLING THROUGH PLC BETA%REACTOME DATABASE ID RELEASE 66%10145577 G beta:gamma signalling through PLC beta Plcb1 Gnb3 Gnb5 Plcb3 Gnb2 Gnb1 Gng13 Gng12 Gng11 LOC100912034 Gnb4 Gng4 Gngt2 Gng5 Gngt1 Gng10 Gng8 Gng3 INHIBITION OF TSC COMPLEX FORMATION BY PKB%REACTOME%R-RNO-165181.1 Inhibition of TSC complex formation by PKB Tsc1 Tsc2 Akt2 NEGATIVE REGULATION OF FGFR1 SIGNALING%REACTOME%R-RNO-5654726.1 Negative regulation of FGFR1 signaling Src Fgf23 Fgf22 Fgf4 Fgf1 Fgf3 Ppp2cb Ppp2ca Fgf6 Fgf5 Ppp2r1a Fgf20 Mknk1 Fgf17 Fgf10 Fgf9 Fgf2 Fgf8 Spry2 Cbl Fgfr1 Mapk1 Ptpn11 Frs2 Grb2 PLASMA LIPOPROTEIN REMODELING%REACTOME%R-RNO-8963899.1 Plasma lipoprotein remodeling Gpihbp1 Lcat Lipg Pltp Angptl4 LOC100361444 Lmf1 Lmf2 Lpl Apoa1 Apob Apoc2 Apoe Apoa2 Abcg1 Pcsk6 Pcsk5 Furin AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE%REACTOME%R-RNO-352230.1 Amino acid transport across the plasma membrane Slc7a3 Slc16a10 Slc7a2 Slc7a1 Slc6a12 Slc1a5 Slc1a4 Slc7a8 Slc7a9 Slc7a5 Slc7a6 Slc7a7 Slc36a2 Slc7a10 Slc38a1 Slc6a15 Slc6a14 Slc6a19 Slc6a18 Slc36a4 Slc6a20 Slc6a6 Slc36a1 Slc38a3 Slc38a2 Slc38a5 Slc38a4 Slc7a11 Slc3a1 Slc25a29 Slc43a2 Slc43a1 APOPTOSIS INDUCED DNA FRAGMENTATION%REACTOME DATABASE ID RELEASE 66%10145440 Apoptosis induced DNA fragmentation Dffa Kpna1 Kpnb1 LOC100911856 Casp3 Hmgb2 RGD1559962 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL%REACTOME%R-RNO-209560.1 NF-kB is activated and signals survival Nfkb1 Sqstm1 Ngf Nfkbia Ngfr Ikbkb Rela Traf6 CELLULAR RESPONSE TO HEAT STRESS%REACTOME%R-RNO-3371556.1 Cellular response to heat stress Nup93 Camk2g Dnajb6 Nup43 Nup98 Nup133 l7Rn6 Nup107 Aaas Camk2d Vcp Camk2a Nup210 Npap60 Hspa14 Hspa13 Nup35 Nup37 Dnajc7 Nupl2 Hdac6 Nupl1 Ccar2 Hsph1 Atm Hspa12b Hspa12a Rpa3 LOC103692716 Ptges3 Ptges3l1 Atr Fkbp4 Nup205 Ranbp2 Crebbp Hsbp1 Dnajb1 Cryab Hsf1 Hspb8 Hspa1l Akt1s1 Hsp90ab1 Hspa2 Nup155 Rpa1 Nup88 Rpa2 Nup85 Ywhae Nup153 Mtor Bag1 Bag2 Bag4 Bag5 Rptor Bag3 Tpr Hspa9 Hspa5 Mlst8 Rae1 Hspa4 Mapkapk2 Mapk1 Nup54 Pom121 Nup62 TRANSPORT OF NUCLEOTIDE SUGARS%REACTOME%R-RNO-727802.1 Transport of nucleotide sugars Slc35c1 Slc35b2 Slc35d2 Slc35a2 Slc35d1 Slc35b3 Slc35a1 Slc35b4 SEPARATION OF SISTER CHROMATIDS%REACTOME DATABASE ID RELEASE 66%10145223 Separation of Sister Chromatids Cenpn Psmc6 Zwilch Cenpl Nup43 Cenpo Psmb10 Nup133 Dync1li2 Psmb8 Cenpt Psmb9 Cenpu Psmb4 Psmb11 Bub3 Psmb5 Bub1 Psmf1 Psmb6 Spdl1 Psmd4 Kntc1 Psmb2 Dync1i2 Psmd5 LOC100910252 Psmd8 Mad1l1 Stag1 Psmd9 Psmb3 Psma8 Cenpk Cenph Nup37 Cenpi Psmd11 Psmd12 Pds5b Pds5a Cenpf Cdca5 Psmd13 Rad21 Cenpe Psmd14 Smc1a Cenpm Stag2 Smc3 Ahctf1 Ndel1 Rcc2 Pafah1b1 Mis12 Dynll2 Psmc3 Ndc80 Cenpc Cenpa Dync1i1 Ranbp2 Birc5 Taok1 Ube2d1 Ppp2cb Ppp2ca Ppp2r1a Nup85 Anapc7 Cdc26 Cdc27 Cdc23 Pttg1 Ube2c Anapc16 Ppp2r1b Cdc16 Anapc4 Anapc2 Anapc1 Nup98 Nup107 Anapc11 Anapc15 Anapc10 Dync1h1 Cdca8 Dync1li1 Rangap1 Ppp1cc LOC100909468 Aurkb Sec13 Xpo1 LOC100911204 Spc24 Spc25 Hdac8 Itgb3bp Sgol2 Ppp2r5e Incenp G6pc Nsl1 B9d2 Cdc20 Kif2a Kif2c Kif2b Psmb7 Bub1b Psmb1 Kif18a Ppp2r5c Ppp2r5a Ppp2r5b Zwint Dsn1 Espl1 Mad2l1 Casc5 Clasp2 Ercc6l Psma5 Nuf2 Clasp1 LOC679582 Psma2 Mapre1 Psmc5 Psma1 Pmf1 Psmd2 Psma4 Psmc1 Psma3 Psmc4 Psma6 Ckap5 Psmc2 Psme1 Ska2 Psme2 Psmd1 Psmd7 Sgol1 Zw10 Psmd3 Ska1 Psmd6 GAMMA-CARBOXYLATION OF PROTEIN PRECURSORS%REACTOME%R-RNO-159740.1 Gamma-carboxylation of protein precursors Ggcx Pros1 Proz Bglap F2 F7 F9 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND%REACTOME DATABASE ID RELEASE 66%10145237 Removal of the Flap Intermediate from the C-strand Rpa1 Slc25a16 Rpa3 Fen1 Rpa2 Pold2 Pcna Pold1 Pold4 SMAC-MEDIATED APOPTOTIC RESPONSE%REACTOME DATABASE ID RELEASE 66%10145021 SMAC-mediated apoptotic response Diablo LOC100360940 Xiap PI-3K CASCADE:FGFR1%REACTOME%R-RNO-5654689.1 PI-3K cascade:FGFR1 Gab1 Fgf17 Pik3r1 Fgf10 Fgf9 Fgf2 Fgf8 Fgfr1 Fgf23 Fgf22 Fgf4 Ptpn11 Fgf1 Fgf3 Fgf6 Fgf5 Frs2 Fgf20 Grb2 METABOLISM OF COFACTORS%REACTOME DATABASE ID RELEASE 66%10145548 Metabolism of cofactors Nos3 Pts Idh1 Spr Prkg2 LOC103692716 Pdss2 Akt1 Gch1 Coq2 Gchfr EUKARYOTIC TRANSLATION ELONGATION%REACTOME%R-RNO-156842.1 Eukaryotic Translation Elongation Eef2 TELOMERE EXTENSION BY TELOMERASE%REACTOME DATABASE ID RELEASE 66%10145110 Telomere Extension By Telomerase Tert SIGNALLING TO ERKS%REACTOME DATABASE ID RELEASE 66%10145182 Signalling to ERKs Shc3 Kras Crk Rap1a Shc2 Mapkapk3 Mapkapk2 Ralgds Ntrk1 Kidins220 Ngf Hras Crkl Nras Sos1 Frs2 Mapk14 Rapgef1 Shc1 Mapk11 Grb2 LOC100911248 LAGGING STRAND SYNTHESIS%REACTOME%R-RNO-69186.1 Lagging Strand Synthesis Rfc1 Rfc2 Rpa3 LOC100911727 Pold2 Pcna Pold1 Pold4 Rpa1 Slc25a16 Rpa2 Fen1 Prim2 Pola2 Prim1 Rfc5 Rfc4 Rfc3 Lig1 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS%REACTOME DATABASE ID RELEASE 66%10145102 Post-translational modification: synthesis of GPI-anchored proteins Tectb Art3 Art4 LOC100910410 Mfi2 Ly6g6c Izumo1r Msln Vnn1 Rtn4rl2 Gpaa1 Rtn4rl1 Lypd5 Ceacam1 Prnd Lypd8 Lypd1 Lypd6b Ntng1 Lypd2 Ntng2 Prss41 Alpp Lypd3 Lypd4 Alpi Sprn Prss21 Alpl Plaur Ly6g6d Cpm Reck Folr2 Spaca4 Fcgr3a Gpihbp1 Tex101 Cd109 Opcml LOC100910849 Pigm Thy1 Pigk Otoa Cntn4 Pigl Cntn3 Pigg Cntn5 Ly6e Pgap1 Ly6d Pigh Psca Ly6h Alppl2 Pigc Pigb Piga Gpld1 Plet1 LOC100910143 Gp2 LOC100910177 Tecta Vnn3 Pigw Pigv Bst1 Pigy Pigx Pign Pigq Pigp Xpnpep2 Pigs Dpm3 Ceacam10 Dpm2 Pigu Dpm1 Pigt DIGESTION OF DIETARY LIPID%REACTOME%R-RNO-192456.1 Digestion of dietary lipid Pnliprp1 Pnliprp2 Pnlip Lipf Clps WNT5A-DEPENDENT INTERNALIZATION OF FZD4%REACTOME DATABASE ID RELEASE 66%10146042 WNT5A-dependent internalization of FZD4 Ap2a2 LOC100361515 Wnt5a Cltc Cltb Dvl2 Clta Arrb2 Fzd4 Prkca Prkcb Ap2s1 Ap2a1 Ap2m1 COMMON PATHWAY OF FIBRIN CLOT FORMATION%REACTOME%R-RNO-140875.1 Common Pathway of Fibrin Clot Formation LOC100909700 F13a1 Pf4 Serpine2 Serpind1 Fgb Fgg Cd177 Serpinc1 Pros1 Thbd Fga F13b Procr F2r F2 F8 Serpina5 ACYL CHAIN REMODELLING OF PS%REACTOME DATABASE ID RELEASE 66%10145868 Acyl chain remodelling of PS Lpcat4 Pla2r1 Pla2g5 Pla2g4e Pla2g4b Mboat1 Pla2g4d Pla2g16 Pla2g2a Pla2g2f Lpcat3 Pla2g2d Pla2g10 Osbpl10 Pla2g1b Pla2g4a Osbpl5 Osbpl8 Pla2g12a ASSEMBLY OF THE ORC COMPLEX AT THE ORIGIN OF REPLICATION%REACTOME DATABASE ID RELEASE 66%10144712 Assembly of the ORC complex at the origin of replication Orc4 Orc5 Orc6 Orc1 Orc2 Orc3 HSF1 ACTIVATION%REACTOME%R-RNO-3371511.1 HSF1 activation Ptges3l1 Hsf1 Hsp90ab1 Hdac6 LOC103692716 Ptges3 Ywhae Vcp NON-CODING RNA METABOLISM%REACTOME%R-RNO-194441.1 Non-coding RNA Metabolism Nup93 Nup43 Snrpf Nup98 Nup133 Nup107 Phax Aaas Nup155 Nup210 Snrpd1 Npap60 Snrpd2 Nup35 Snrpd3 Nup88 Snupn Nup37 Nupl2 Nupl1 Nup85 Nup153 Ncbp2 Ncbp1 Tpr Ddx20 Gemin7l1 Rae1 Tgs1 Gemin5 Gemin7 Gemin6 Nup54 Gemin8 Smn1 Pom121 Nup205 Ranbp2 Gemin2 Nup62 Snrpb REGULATION OF TP53 ACTIVITY THROUGH PHOSPHORYLATION%REACTOME DATABASE ID RELEASE 66%10144756 Regulation of TP53 Activity through Phosphorylation Rhno1 Rfc2 Bard1 Wrn Topbp1 Rbbp8 Mdm2 Rmi1 Rmi2 Dyrk2 Rad50 Cdk5 Csnk2a2 Tp53rk LOC364561 Pin1 Supt16h Csnk2a1 LOC685619 Ccna2 Ccna1 Aurka Plk3 Prkab1 Prkab2 Atm Atrip Cdk2 Rpa3 Atp5c1 Aurkb Taf7l Brca1 Rad1 Atr Blm Mapkapk5 Rad17 Rfc5 Rfc4 Rad9a Nbn Rfc3 Rad9b Tbp Mre11a Hus1 Cdk5r1 Taf11 Taf15 Taf2 Rpa1 Nuak1 Hipk2 Rpa2 Taf13 Taf9 Taf12 Taf7 Taf4b Taf3 Taf6 Noc2l Taf5 Tp53inp1 Csnk2b Prkag3 Tpx2 LOC100910954 Hipk1 Mdm4 Chek2 Prkaa1 Taf10 Prkaa2 Slc25a16 Ssrp1 Mapk14 Mapk11 Taf9b MITOCHONDRIAL TRANSLATION TERMINATION%REACTOME DATABASE ID RELEASE 66%10146065 Mitochondrial translation termination Mrps11 Mrps12 Mrps16 Mrps14 Mrps18b Mrps18c Mrps10 Mrps18a Mrps33 Mrps34 Mrps21 Mrps35 Mrps17 Mrps15 Mrps31 Mrps30 Mrps24 Mrps23 Mrps22 mrpl9 Mrps28 Mrps27 Mrps26 Mrps25 Mrpl4 Mrpl3 Mrpl2 Oxa1l Mtrf1l LOC367117 Mrrf Mrpl1 Mrpl13 Mrpl10 Mrpl18 Mrpl19 Mrps9 Mrps2 Mrps5 Mrps7 Mrpl36 Mrpl37 Mrpl20 Mrpl14 Mrpl16 Mrpl12 Mrpl15 Mrpl41 Mrpl35 Mrpl40 Mrpl33 Mrpl34 Mrpl38 Mrpl32 Mrpl27 Mrpl23 Mrpl28 Mrpl30 Mrpl21 Mrpl54 Mrpl46 Mrpl55 Mrpl44 Mrpl43 Mrpl47 Mrpl49 Mrpl53 Mrpl48 Mrpl52 Mrpl51 Mrpl50 mrpl11 mrpl24 Chchd1 Dap3 Eral1 Gadd45gip1 Ict1 Ptcd3 Gfm2 CONJUGATION OF CARBOXYLIC ACIDS%REACTOME DATABASE ID RELEASE 66%10145090 Conjugation of carboxylic acids Glyatl3 Acsm1 Glyat OPSINS%REACTOME%R-RNO-419771.1 Opsins Opn1sw Rgr Opn5 Opn3 Opn4 Opn1mw TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES%REACTOME DATABASE ID RELEASE 66%10144951 Transport of vitamins, nucleosides, and related molecules Slco1a1 Slc35b2 Slc35c1 Slc5a6 Slco4a1 Pdzd11 Slc27a6 Slco1a4 Slc35b3 Slco1a2 Slco4c1 Slco2b1 Lcn1 Slco1b2 Slc27a4 Slc33a1 Slc35a2 Slc16a2 Slc21a4 Slc35b4 Avp Slco1a6 Slc28a2 Slc35d1 Slc28a1 Slco3a1 Slc28a3 Slc29a3 Slc35a1 Slc29a2 Slc29a4 Lcn12 LOC100911721 Slc29a1 LOC691960 Slc35d2 Slco2a1 Apod Vegp2 Slco1c1 Lcn9 Slc27a1 EICOSANOID LIGAND-BINDING RECEPTORS%REACTOME%R-RNO-391903.1 Eicosanoid ligand-binding receptors Ptgir Gpr17 Tbxa2r Ptgdrl Ptger3 Ltb4r Cysltr2 Cysltr1 Ltb4r2 Ptgdr Ptgfr Ptger2 Ptger1 Ptgdr2 FRUCTOSE METABOLISM%REACTOME%R-RNO-5652084.1 Fructose metabolism Aldob Khk Glyctk Akr1b1 Sord Tkfc B-WICH COMPLEX POSITIVELY REGULATES RRNA EXPRESSION%REACTOME DATABASE ID RELEASE 66%10146051 B-WICH complex positively regulates rRNA expression Myo1c Kat2a RGD1565904 Polr1b Taf1d Polr2h Taf1c Cd3eap Polr2e Znrd1 Polr2f Polr1c Polr1a Polr2k Hist1h2bo Hist1h2bcl1 Hist2h3c2 LOC100912534 Hist1h2bk Actb H3f3b Sf3b1 Smarca5 Tbp LOC100910200 H2afx Hist1h4b LOC684841 Hist1h2bh LOC100912290 Hist1h2ail1 Hist1h4m LOC102549173 Mybbp1a LOC103690002 LOC100910152 LOC100912338 Hist1h3c H2afb3 Hist1h3f Ercc6 Hist2h4 LOC684819 Hist1h3a H2afj Hist2h2aa3 Hist1h2bq Hist2h2aa2 Ddx21 LOC100364835 Baz1b LOC684762 Twistnb Polr1e Hist1h2bg LOC680097 LOC684797 LOC100912418 Hist1h2ba Hist3h2bb Dek PCNA-DEPENDENT LONG PATCH BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 66%10144982 PCNA-Dependent Long Patch Base Excision Repair Rfc1 Rfc2 Rpa3 Pole2 Pole4 LOC100911727 Pole Polb Pold2 Pcna Pold1 Pold4 Rpa1 Rpa2 Fen1 Apex1 Rfc5 Rfc4 Rfc3 Lig1 TNFS BIND THEIR PHYSIOLOGICAL RECEPTORS%REACTOME DATABASE ID RELEASE 66%10146122 TNFs bind their physiological receptors Tnfsf13b Tnfrsf9 Tnfrsf8 Edaradd Tnfrsf4 Eda2r Tnfrsf1b Cd70 Tnfrsf17 Tnfrsf14 Tnfsf8 Tnfsf9 Tnfrsf25 Edar Tnfrsf11b Tnfsf4 Eda Tnfsf11 Lta Tnfsf13 Cd27 INTERLEUKIN-37 SIGNALING%REACTOME DATABASE ID RELEASE 66%10146292 Interleukin-37 signaling Tbk1 Stat3 RETROGRADE NEUROTROPHIN SIGNALLING%REACTOME%R-RNO-177504.1 Retrograde neurotrophin signalling Dnal4 Ap2a2 Ntrk1 Clta Ngf Sh3gl2 Ap2s1 Ap2a1 Ap2m1 Cltc PRPP BIOSYNTHESIS%REACTOME%R-RNO-73843.1 PRPP biosynthesis Prps1l1 Prps2 RHO GTPASES ACTIVATE KTN1%REACTOME%R-RNO-5625970.1 RHO GTPases activate KTN1 Rhoa Klc1 Ktn1 Klc4 Kif5b Rhog Kif5a Klc2 Rac1 Klc3 Cdc42 PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS%REACTOME%R-RNO-202427.1 Phosphorylation of CD3 and TCR zeta chains Cd247 Ptprc Csk Ptpn22 Ptprj Cd3g Cd3e RT1-Ba Cd3d RT1-Bb RT1-Da RT1-Db2 Cd4 RT1-Db1 LOC688090 ACTIVATION OF GABAB RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145188 Activation of GABAB receptors Kcnj4 Kcnj6 Gnai3 Gnal Gnat3 Adcy3 Adcy8 Adcy9 Adcy5 Gnai2 Adcy4 Adcy7 Adcy6 Gnb3 Kcnj16 Gnb2 Gnb1 Gng12 Kcnj2 Kcnj3 Kcnj15 Kcnj9 Kcnj5 Gng4 Gngt2 Gnai1 Gng5 Gabbr1 Gngt1 Kcnj12 Gng10 Gng8 Gabbr2 Gng3 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS%REACTOME%R-RNO-442742.1 CREB phosphorylation through the activation of Ras Grin2d Camk2g Rras Grin2b Grin1 Nefl Rasgrf1 Dlg1 Raf1 Dlg2 Dlg3 Camk2d Pdpk1 Actn2 Camk2a Mapk1 Rps6ka2 Rps6ka1 Lrrc7 Rps6ka3 Creb1 Rps6ka6 Hras Dlg4 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 66%10145158 Activation of the AP-1 family of transcription factors Jun Mapk9 Mapk8 Fos Mapk14 Atf2 Mapk11 Mapk10 Mapk1 SYNTHESIS OF DOLICHYL-PHOSPHATE-GLUCOSE%REACTOME DATABASE ID RELEASE 66%10145673 Synthesis of dolichyl-phosphate-glucose Nudt14 PTK6 REGULATES RTKS AND THEIR EFFECTORS AKT1 AND DOK1%REACTOME DATABASE ID RELEASE 66%10146206 PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 Arap1 Dok1 Cbl Akt1 Ptk6 COHESIN LOADING ONTO CHROMATIN%REACTOME%R-RNO-2470946.1 Cohesin Loading onto Chromatin Stag1 Pds5b Pds5a Rad21 Smc1a Mau2 Stag2 Smc3 SEMA3A PAK DEPENDENT AXON REPULSION%REACTOME DATABASE ID RELEASE 66%10145582 Sema3A PAK dependent Axon repulsion Plxna2 Plxna1 Fyn Hsp90ab1 LOC103692716 Nrp1 Rac1 Limk1 Pak2 Fes Pak3 Pak1 Sema3a ATTENUATION PHASE%REACTOME DATABASE ID RELEASE 66%10146014 Attenuation phase Ptges3l1 Hsbp1 Dnajb1 Hsf1 Fkbp4 Hspa1l Hsp90ab1 Hspa2 Crebbp LOC103692716 Ptges3 RNA POLYMERASE II TRANSCRIPTION%REACTOME DATABASE ID RELEASE 66%10144750 RNA Polymerase II Transcription Thoc5 Rfc2 Thoc7 Thoc3 Gtf2h1 Thoc2 Gtf2h2 Usp7 Thoc1 Mdm2 Nrbf2 Zfp28-ps1 Zfp445 Banp Zfhx3 Notch3 Rarg Esr2 Mnat1 Thoc6 Rbx1 RGD1565904 Nr2c2ap Cdk5 Ice2 Hnf4a RGD1308751 Leo1 Zc3h8 Polr2g Hnf4g Polr2h Zfp473 Polr2e Nr4a3 Polr2f Nr4a1 Polr2j Nr4a2 Polr2k LOC685619 Polr2d Zfp212 Polr2i Zfp418 Polr2b Pml Ddx39a Polr2c Zfp213 Ddx39b Polr2a Zfp867 Actl6a Ice1 Chtop Esrra Esrrb LOC100912534 Triap1 Elf1 Ell Sumo1 Elf2 Rpa3 Tp53bp2 Nr6a1 Nr2c2 Nr2c1 Atp5c1 Cited2 Iws1 Zkscan1 Tcea1 Zfp263 Pcna Zfp266 Taf7l Brca1 Zfp496 Ccnh Blm LOC102555919 Mapkapk5 Rara Pcgf2 Rarb Yap1 Zfp498 Tead2 Pidd1 Tead1 Nr2e1 Ube2i Hdac4 Ppm1d Zfp483 Nr2f6 Rbm14 Gtf2h3 Rfc5 Nr2f1 LOC100911677 Rfc4 Zfp287 Rfc3 LOC691135 Sox9 Nr2e3 Gtf2h5 Thra Zfp282 Gtf2h4 Thrb Zfp786 Smad3 Ing2 Aff4 Actl6b Ccnt2 Zfp770 Smad2 Smarce1 Zfp771 Zfp354c Nr1h3 Gtf2e1 Nr1h2 Pbrm1 Tceb3 Arid1b Zfp354a Arid1a Usp9x Sp1 Zfp791 Ube2d1 Gtf2e2 Skil Zfpm1 Rbl1 Nr5a1 Cdk4 Ncor2 Cdk9 Akt1 Rora Nr1i2 E2f4 Supt6h Smarcd1 LOC102554302 Hdac1 Tgif2 Smarcd2 Ercc3 Tgif1 LOC100911274 Smarcd3 Atp1b4 Brpf3 Nuak1 Rpa1 Trim33 Ccnd1 Foxp3 Rpa2 Ccnk Brpf1 Ube2d3 LOC100911822 LOC100363472 Brd1 Taf7 Nr1i3 Cpsf3l Wwtr1 Tfdp1 Taf3 Ercc2 Kat6a Taf6 Tfdp2 Taf5 Ing5 Taf8 Stub1 Zfp202 Tp53inp1 MGC114246 Zfp839 Zfp420 LOC100911519 Tbx5 Runx2 Rxrg Tp63 Nrbp1 Yaf2 Zfp426 LOC102553866 Fyttd1 Nelfe Nelfa Nelfb Gtf2b Testin Znf740 Cradd Bnip3l Slc25a16 Asun RGD1562299 Znf750 Ssrp1 L3mbtl1 L3mbtl2 Zfp775 Zfp777 Dek LOC361990 Ints4 Ints5 Ints6 Map2k6 Ints7 Ints9 Zfp746 Phax Zfp583 Ints1 Ints3 Ints2 Zfp180 Zfp189 Dyrk2 Epc1 Cul1 Zfp804b Zfp703 Tp53rk LOC100911224 Zfp707 Zfp710 Supt16h Zfp711 Krba1 Ssu72 Zfp566 Zfp169 Zfp167 Vwa9 Zfp383 Zfp37 Zfp113 Zfp110 Zfp382 Zfp112 Zfp46 Zfp398 Zfp111 Trim28 Zfp394 Zfp2 LOC100364523 Sarnp Zfp317 Zfp597 Zfp74 LOC501406 Zfp9 Zfp1 Zfp84 Nabp1 Nabp2 Rslcan18 Serpinb13 Slu7 Zfp90 Zim1 Zfp641 Zfp647 LOC102549842 LOC102555083 LOC102546354 Auts2 Pax5 LOC102553962 Mga Zfp668 Snapc3 Cdk5r1 Snapc4 Lsm10 Lsm11 Zfp667 Psmb7 Prelid1 Psmb1 Taf11 LOC679894 Ctsl Taf15 Zfp248 Esrrg Ctsm Taf13 Ctsj Taf12 RGD1564657 Mllt1 Ctsk Taf4b Ctsq Rpap2 Ctsr Nr0b1 Noc2l Nr0b2 Poldip3 Psma5 Max Parp1 Supt4h1 Pou4f2 Zfp286a Cdk7 Hipk1 E2f6 Zfp324 Psma2 Slbp Psmd2 Brd2 Zfp697 Zfp612 Cts8 Zfp692 Cts7 Zfp691 Psmc2 Snapc5 Snapc2 Ppp1r13b Psmd1 LOC100910137 Psmd7 RGD1564827 Ppp1r13l Zfp606 Ttc5 Zfp688 Psmd3 Rorb Psmd6 Rhno1 Bard1 Wrn Snrpf Topbp1 Rbbp8 Rmi1 Rmi2 Wdr33 Rad50 Lhb Gata2 LOC100911167 LOC364561 Pin1 Brd7 Sesn2 Tal1 Plk2 Ldb1 Txnrd1 Ccne2 Sesn1 Plk3 RragB Ccne1 Tp73 Prkab1 Sesn3 Gata1 Lmo2 Prkab2 Gsr Lmo1 Atrip Cts8l1 Cdk2 E2f7 E2f8 Btg2 Cnot6l Cnot11 Rad1 Atr Rad17 Tgfb1 Setd8 Tmem55b Rad9a Nbn Pip4k2b Cga Rad9b Pip4k2c Mre11a Rbbp5 Srsf3 Upf3b U2af2 Papola Hus1 Srsf6 Srsf7 Srsf4 Tfap2a Srsf5 Srsf2 Tnks1bp1 Cnot8 Rqcd1 Ppp2cb Cnot3 Ppp2ca Cnot1 Skp1 Srsf9 Ppp2r1a Cnot2 Dhx38 Clp1 Cnot7 Cnot4 Phc1 Magoh Phc2 Ncbp2 Mtor Prdx1 Srsf1 Ddit4 Rheb Prkag3 Rptor Lamtor4 Ncbp1 LOC502894 Tfap2b Tsc1 Tfap2c Lamtor5 Sin3a Ppp2r1b Txn1 Cstf2t Sin3b Mlst8 Eif4a3 Prkaa1 Sympk Tsc2 Tfap2d Rraga Tfap2e Prkaa2 Rragc Akt3 LOC100910660 Rragd Srrm1 Slc38a9 Mapk14 Cdc40 Mapk11 Snrpb Rxra Pparg Prmt5 Prmt6 Hist1h2bo Hist1h2bcl1 Scmh1 Cbx4 Hist2h3c2 Cbx2 Hist1h2bk H3f3b Cbx8 Smurf1 Cbx6 Bmi1 Hdac2 Rnf2 Mbd3 E2f5 Ring1 Smarca4 Hdac1l Chd3 Smarca2 Snw1 Chd4 Phc3 LOC100911617 Arid2 Zfp385a Smarcc1 Smarcc2 Smarcb1 Mta2 Gatad2a Cdk6 Meaf6 Gatad2b LOC100909949 Eed Cdc73 Atad2 Ccnd3 LOC100910200 H2afx Hist1h4b Wdr5 LOC684841 Kmt2a Smyd2 Hist1h2bh LOC100912290 Rbbp7 Hist1h2ail1 Hist1h4m LOC102549173 LOC103690002 Ehmt2 LOC100910152 Ehmt1 LOC100912338 Hist1h3c H2afb3 Hist1h3f Hist2h4 Cenpj LOC684819 Hist1h3a H2afj Hist2h2aa3 Hist1h2bq Hist2h2aa2 Ash2l LOC100364835 Dpy30 LOC684762 Cited4 Yeats4 Tcf7 Hist1h2bg Ezh2 Lef1 Tcf7l1 LOC680097 LOC684797 LOC100912418 Hist1h2ba Hist3h2bb Nr1h4 Maml1 Rbpj Kat2a Rbpjl2 Csnk2a2 Csnk2a1 LOC100909750 Paf1 Vdr Rtf1 Hipk2 Supt5h Rnmt Rngtt Skp2 Cdkn1a Cdkn1b Chm Gadd45a Bax Rnps1 Magohb Rbm8a Pcf11 Fip1l1 Rabggta Nudt21 Snrpd3 Ppara Ppard Aurka Cstf2 U2af1l4 Cpsf7 Cdc25c Cpsf2 Cpsf3 Cpsf4 Cstf1 Cpsf1 Aurkb Rabggtb Abl1 G6pc Men1 Ppp2r5c Gpi Pdpk1 Psmc6 Psmb10 Psmb8 Psmb9 Psmb4 Psmb11 Psmb5 Psmf1 Psmb6 Psmd4 Psmb2 Psmd5 Psmd8 Psmd9 Psmb3 Psma8 Psmd11 Psmd12 Ccna2 Ctr9 Ccna1 Psmd13 Rffl Ccng1 Psmd14 Phf20 Atm Rictor Wdr61 Tceb2 Tceb1 Psmc3 Src Ywhah Ywhag Sfn Ywhaz Ywhab Ywhaq Ywhae Med1 Lamtor3 Cited1 Nr5a2 Gtf2f1 Gtf2f2 Lamtor2 Lamtor1 Gtf2a1 Bmyc Prmt1 Esr1 Pou2f1 Cbfb Gata3 Crebbp Pgr Tbp Runx1 Akt2 Nr1d1 Notch1 Pcgf6 Rprd1a Kras Nr1d2 Pcgf5 Notch4 Cdk12 Eaf1 Eaf2 Taf2 Zfp14 Slmo1 Taf9 RGD1562871 Ell3 Zfp12 Casp2 Ell2 Cdk13 Zfp13 Rprd1b Zfp28 Zfp18 Csnk2b Usp2 Tpx2 Daxx LOC100910954 Cdk1 Mdm4 Chek2 Rnf34 Taf10 Mapkap1 Sgk1 Psmc5 Psma1 Psma4 Psmc1 Ptpn11 Psma3 Notch2 Psmc4 Psma6 Psme1 Psme2 Taf9b ROLE OF ABL IN ROBO-SLIT SIGNALING%REACTOME%R-RNO-428890.1 Role of ABL in ROBO-SLIT signaling LOC100909750 Abl2 Robo1 Abl1 Slit2 SIGNALING BY FGFR3%REACTOME DATABASE ID RELEASE 66%10145259 Signaling by FGFR3 Src Kras Pik3r1 Frs3 Fgf23 Fgf22 Fgf4 Fgf1 Ppp2cb Fgf3 Ppp2ca Fgf6 Ppp2r1a Fgf5 Fgf20 Mknk1 Gab1 Fgf16 Fgf17 Fgf10 Fgf9 Fgfr2 Fgf2 Fgf7 Cbl Spry2 Fgf8 Fgfr3 Fgfr1 Mapk1 Fgfr4 Ptpn11 Plcg1 Fgf19 Hras Nras Frs2 Sos1 Shc1 Galnt3 Grb2 COLLAGEN FORMATION%REACTOME%R-RNO-1474290.1 Collagen formation Mmp7 Col19a1 LOC100911730 Mmp9 Pcolce RGD1308751 Cd151 Lamc2 Itgb4 Itga6 Col22a1 Col16a1 Col5a2 Col5a1 Cts8l1 Col4a5 Col27a1 Col9a1 Col9a2 Col9a3 Lox Plec Col4a1 Col5a3 LOC100364523 Bmp1 Col4a2 Col4a3 Crtap Col7a1 Col23a1 Lamb3 Col6a5 Col6a6 Col20a1 P4ha1 P4ha2 P4ha3 Dst LOC100910835 Col13a1 Mmp13 LOC100910384 Adamts3 Serpinh1 Ctsb Col8a1 Ctsl Col8a2 Col3a1 Ctsm Ctsj RGD1564657 Col28a1 Col1a1 Ctsq Ctsr Col1a2 Ppib Col6a1 Col6a2 Col18a1 MGC114246 P4hb Adamts14 Tll2 Col11a2 Col11a1 Mmp20 Tll1 Testin LOC100911572 P3h3 Loxl4 Cts8 Colgalt2 Cts7 Col26a1 Col14a1 Plod2 Plod1 Loxl1 RGD1564827 LOC102555086 Colgalt1 Plod3 Col17a1 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION%REACTOME%R-RNO-3134963.1 DEx H-box helicases activate type I IFN and inflammatory cytokines production Nfkb2 Nfkb1 App Ager S100b Dhx9 Rela Myd88 Dhx36 SUMOYLATION OF SUMOYLATION PROTEINS%REACTOME DATABASE ID RELEASE 66%10146029 SUMOylation of SUMOylation proteins Nup93 Nup43 Nup98 Nup133 Nup107 Aaas Nup155 Nup210 Npap60 Nup35 Nup88 Nup37 Pias4 Nupl2 Nupl1 Nup85 Nup153 Sumo1 Tpr Rae1 Nup54 Pom121 Nup205 Ube2i Ranbp2 Nup62 Topors REGULATED NECROSIS%REACTOME%R-RNO-5218859.1 Regulated Necrosis Faslg Cflar Fadd Birc3 Birc2 Mlkl Ripk3 Traf2 Ripk1 Tradd Xiap Tnfsf10 Casp8 Fas SYNTHESIS OF 15-EICOSATETRAENOIC ACID DERIVATIVES%REACTOME DATABASE ID RELEASE 66%10145944 Synthesis of 15-eicosatetraenoic acid derivatives Alox15b Gpx4 Ptgs2 Alox15 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA%REACTOME%R-RNO-212718.1 EGFR interacts with phospholipase C-gamma Plcg1 Egfr PHOSPHORYLATION OF EMI1%REACTOME DATABASE ID RELEASE 66%10145225 Phosphorylation of Emi1 Cdk1 Cdc20 Fzr1 Fbxo5 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY%REACTOME%R-RNO-3301854.1 Nuclear Pore Complex (NPC) Disassembly Nup93 Nup43 Nup98 Nup133 Nup107 Aaas Nup155 Nup210 Npap60 Nup35 Nup88 Nup37 Nupl2 Nupl1 Nup85 Nup153 Tpr Cdk1 Rae1 Nup54 Pom121 Nek6 Nup205 Ranbp2 Nup62 Nek7 REPRESSION OF WNT TARGET GENES%REACTOME DATABASE ID RELEASE 66%10146038 Repression of WNT target genes Ctbp2 Tle3 Tcf7 Lef1 Tcf7l1 Tle4 Tle1 Tle2 APOPTOTIC EXECUTION PHASE%REACTOME DATABASE ID RELEASE 66%10145388 Apoptotic execution phase Prkcd Bmx Kpnb1 Rock1 Apc Dsg3 Dsg2 Birc2 Sptan1 Lmna Dffa Kpna1 LOC100911856 Casp3 Mapt Casp6 Hmgb2 RGD1559962 Stk26 Stk24 Add1 Acin1 Gas2 Ocln Tjp2 Bcap31 Dsp Cdh1 Casp8 Dsg1 Clspn Prkcq Dnm1l Plec Gsn Lmnb1 Pkp1 Vim Dbnl Fnta Ptk2 Satb1 RUNX3 REGULATES NOTCH SIGNALING%REACTOME%R-RNO-8941856.1 RUNX3 regulates NOTCH signaling Notch1 Maml1 Rbpj Crebbp Kat2a Snw1 Rbpjl2 VEGFR2 MEDIATED CELL PROLIFERATION%REACTOME DATABASE ID RELEASE 66%10146032 VEGFR2 mediated cell proliferation Prkcd Kras Src Kdr Pdpk1 Vegfa Prkca Plcg1 Prkcb Hras Nras Rasa1 Prkcz NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145596 Nucleotide-like (purinergic) receptors P2ry6 Lpar6 P2ry4 P2ry1 Gpr17 Lpar4 Adora3 Adora2a Adora2b LOC100911796 P2ry12 P2ry2 LOC100363178 Adora1 P2ry10 LOC100365814 P2ry13 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 27-HYDROXYCHOLESTEROL%REACTOME%R-RNO-193807.1 Synthesis of bile acids and bile salts via 27-hydroxycholesterol Nr1h4 Akr1d1 Ptgis Ncoa2 Akr1c2 Akr1c3 Akr1c12l1 Cyp7a1 Rxra Cyp8b1 Akr1c19 Akr1c13 Akr1c14 RGD1564865 Cyp7b1 Hsd3b7 Akr1c12 Ncoa1 Akr1c1 INTEGRIN SIGNALING%REACTOME DATABASE ID RELEASE 66%10145478 Integrin signaling Fn1 Src Csk Tln1 Crk Rasgrp1 Rasgrp2 Rap1a Vwf Apbb1ip Ptpn1 Bcar1 Fgb Fgg Pdpk1 Akt1 Rapgef4 Fga Itga2b Ptk2 Sos1 Shc1 Syk Grb2 G ALPHA (I) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 66%10144868 G alpha (i) signalling events Plcb1 Cnga1 Ppp1ca Pde4a Gucy2f Pde6b Plcb3 Rcvrn Gucy2d Pde4d Pde4c Pde6a Rgs9 Ppp1r1b RGD1560341 Cdk5 Stra6 Rdh10 Rdh16 LOC100365958 LOC100362350 Akr1c12l1 Plcb4 Guca1b Ppef1 Kng1l1 Metap2 Metap1 Gnat1 Akr1c19 Nmt1 Guca1a Cngb1 Rgs9bp Fnta Nmt2 Akr1c13 Akr1c14 Sag Grk4 Grk1 Akr1c12 Fntb Pde6g Ccr6 Gnai3 Pomc Pnlip Apoa1 Gnao1 Chrm4 Rpe65 Clps Gnat2 Dhrs9 Myo7a Gnaz Sdr9c7 Hsd17b6 Gpc6 Gpc4 Gpc2 Abca4 Prkca Gpc1 Opn1sw Oprl1 Tas2r144 Grm3 Ccl21 Casr Dhrs3 Rlbp1 Ccr5 Grm6 Gal Tas2r113 Ccr4 Grm2 Ccr3 Grm8 Gpr37 Ccl27 Tas2r114 Tas2r110 Gper1 Ccl20 Ccl25 Akr1b7 NMS Akr1b8 Tas2r124 Cxcl16 App Tas2r125 Pdyn Tas2r126 Tas2r121 Ccr10 Tas2r103 Gpr37l1 Tas2r104 Tas2r123 Ccl19 Ccr7 Tas2r116 Ccr8 Tas2r140 Tas2r120 Cxcr3 Cxcl10 Tas2r102 Ccr9 Opn1mw Tas2r145 Cxcl11 Tas2r119 Tas2r118 Tas2r117 Pde1b Sstr5 Tas2r107 Npbwr1 Tas2r108 Pyy Tas2r105 Pnoc Tas2r106 Akr1c2 Ccl5 Tas2r129 Npy2r Tas2r109 Tas2r136 Akr1c3 Tas2r137 Tas1r1 Oprm1 Tas2r135 Mchr1 Sstr1 Tas2r13 Aplnr Tas2r130 Sstr4 Tas1r3 Sstr2 Tas2r139 Npy1r Apln Apob Bdkrb1 Apoc2 Bdkrb2 Apoe Apoa2 Rln3 Npb Ppy Ccl1 Npw Gng10 Npy Akr1c1 Agrn Gpihbp1 Sstr3 Penk C5ar1 Kng1 Kng2 Cxcr5 Npy5r Nmur2 Cxcr6 Oprd1 Psap Oxgr1 Sdc2 Sdc3 Sdc4 Ccr1 Ccr1l1 Ptgdr2 Sucnr1 Adcy8 Awat2 Adcy9 Adcy5 Adcy4 Adcy7 Adcy6 Prkar1b Adra2b Prkar1a Ttr Cxcr2 RGD1564865 Hebp1 Fpr-rs6 Nmu Fpr-rs3 Pf4 Fpr2 Fpr3 Anxa1 Pmch Gnal Fpr-rs4 Rxfp3 Lpar5 Gnat3 S1pr1 S1pr5 S1pr4 S1pr3 Ppp2cb Ppp2ca Cx3cr1 Lpar1 Lpar3 Ppp2r1a Lpar2 Sst S1pr2 Ackr3 Cxcl9 Cxcl6 Cx3cl1 Gpr31 Ccl9 Cxcl2 Rgr Cxcl1 Ccl6 Gpr18 Gpr55 Gpsm3 Htr5a Gpsm2 Cxcl3 Agt Gpsm1 Gnb3 Cnr2 Gnb5 Ccl4 Opn3 Ppp2r1b Gnb2 Cnr1 Gnb1 Htr1d Gng13 Htr1f Gng12 Htr1a Gng11 Mapk1 Htr1b Hrh4 Prkaca Ptger3 Prkacb Adora3 Gpr183 Agtr2 Mtnr1a Opn5 Galr1 Pcp2 LOC100912034 Hcar1 Gnb4 Oprk1 Hcar2 Camk4 Gng4 Gngt2 LOC100911796 Drd4 Gng5 LOC100363178 Drd2 Gngt1 Adora1 Gng8 LOC100365814 Gng3 Fpr1 Pla2g4a Chrm2 Gabbr1 Gabbr2 C3ar1 Prkcd P2ry4 Gpr17 Cxcl12 Adcy3 Prkar2b Prkar2a P2ry12 Cxcr4 P2ry13 Adra2a Gnai2 Adra2c Rbp4 Lrp1 C3 Lrp10 Rbp2 Ppbp Tex12 Rbp1 Lrp8 Apom Lrp12 Lpl Bco1 Rdh11 Lrat Bco2 Adrbk1 Gnai1 Cyp4v3 TRANSMISSION ACROSS CHEMICAL SYNAPSES%REACTOME%R-RNO-112315.1 Transmission across Chemical Synapses Plcb1 Slc6a11 Slc6a13 Slc6a1 Cacna1e Slc6a12 Mdm2 Raf1 Plcb3 Rims1 Cplx1 Syt1 Vamp2 Stxbp1 Ppfia1 Ppfia2 Ppfia3 Ppfia4 Ap2a2 Adcy8 Adcy9 Gad2 Adcy5 Adcy4 Adcy7 Adcy6 Slc38a2 Gad1 Abat Aldh5a1 Gabrr1 Maoa Gabrr3 Gabrr2 Slc22a1 Slc22a2 Aldh2 Comt Slc6a4 Slc6a3 Bche Lrtomt Chat Gnai3 Ache Slc1a3 Gnal Slc1a7 Rab3a Slc1a6 Slc1a1 Gnat3 Prkcb Nsf Ap2s1 Bzrap1 Ap2a1 Myo6 Ap2m1 Camkk1 Kcnj16 Gnb3 Gnb5 Gnb2 Gnb1 Chrne Gng13 Chrnd Gng12 Mapk1 Gng11 Cacnb4 Stx1a Cacng8 Cacnb1 Cacnb2 Creb1 Cacna2d3 LOC100912034 Prkca Gnb4 Cacng2 Cacng3 Camk4 Gng4 Cacna2d2 Cacng4 Slc5a7 Gngt2 Gng5 Gngt1 Gng8 Dlg4 Gng3 Grin2d Camk2g Grin2b Grin1 Chrnb4 Nefl Rasgrf1 Dlg1 Dlg2 Glra4 Dlg3 Htr3b Camk2d Htr3a Actn2 Camk2a Glrb Lin7c Rps6ka2 Lin7a Rps6ka1 Syn3 Syn2 Rps6ka3 Chrna4 Chrna5 Chrna9 Chrna6 Chrnb2 Chrna7 Chrnb3 Syn1 Chrna2 Apba1 Chrna3 Chrna1 Kcnj2 Kcnj3 Kcnj15 Glul Kcnj9 Kcnj5 Cacna1b Gabbr1 Kcnj12 Gng10 Gabbr2 Rras Kcnj4 Kcnj6 Gria3 Gria4 Grip1 Grip2 Pick1 Lrrc7 Adcy3 Akap5 Slc32a1 Slc38a1 Lin7b Gabra5 Dnajc5 Gabra6 Gabrb1 Gabrg2 Gabra1 Gnai2 Gabra2 Grik1 Grik3 Grik2 Ncald Grik5 Slc17a7 Pdpk1 Naaa Rps6ka6 Hras Gnai1 Gabra4 Gabrb2 FGFR2 LIGAND BINDING AND ACTIVATION%REACTOME%R-RNO-190241.1 FGFR2 ligand binding and activation Fgf16 Fgf17 Fgf10 Fgf9 Fgfbp3 Fgfbp1 Fgfr2 Fgf7 Fgf2 Fgf8 Fgf23 Fgf22 Fgf4 Fgf1 Fgf3 Fgf6 Fgf5 Fgf20 SIGNALING BY NON-RECEPTOR TYROSINE KINASES%REACTOME DATABASE ID RELEASE 66%10146199 Signaling by Non-Receptor Tyrosine Kinases Ereg Nrg1 Kras Btc LOC100909609 LOC102552659 Erbb3 Erbb2 Pxn Srms Nrg3 Ptpn1 Stat3 Egfr Hbegf Cdk4 Akt1 Rac1 Arhgap35 Ptk6 Nrg4 Socs3 Ccnd1 Dok1 Ccne1 Cdk2 Arap1 Crk Cdkn1b Lrrk2 Bcar1 Stap2 Cbl Khdrbs2 Hif1a Gpnmb Khdrbs1 Khdrbs3 Rhoa Dock1 Erbb4 Hras Nras Elmo2 Rasa1 Nrg2 CARDIAC CONDUCTION%REACTOME%R-RNO-5576891.1 Cardiac conduction Stim1 Dmpk Sri Tnni3 Kcnd3 LOC100911951 Kcnd1 Kcnip3 Kcnip4 Kcnip2 Akap9 Kcnk16 Slc8a3 Ahcyl1 Slc8a2 Slc8a1 Cacna1c Cacng7 Cacna1d Cacng1 Kcne1 Kcne2 Kcnk5 Cacng5 Kcnk6 Kcne4 Kcnk7 Scn2a Scn7a Scn4b Scn2b Fgf11 Scn9a Fgf12 Fgf13 Scn10a Scn4a Nos1 Scn5a Fgf14 Scn3a Scn11a Rangrf Scn1b Kcne3 Prkaca Cacnb4 Itpr1 Cacnb1 Cacng8 Cacnb2 Kcnq1 Itpr3 Cacna2d3 Cacna1f Kcne5 Cacng2 Cacna1s Cacng3 Cacna2d2 Cacng4 Cacna2d4 Camk2g Atp2b4 Kcnh2 Atp2b2 Atp2b1 Camk2d Camk2a Clic2 Trdn Atp2a2 Pln Atp2a3 Kcnj2 Kcnj11 Kcnj14 Kcnk1 Kcnk12 Kcnk13 Kcnk2 Kcnk3 Npr2 LOC100909725 Npr1 Kcnk4 Nppc Kcnk10 Kcnj12 Nppa Kcnk9 Corin Abcc9 Kcnk15 Fxyd2 Kcnj4 Fxyd3 Fxyd4 Sln Fxyd6 Fxyd7 Atp1b3 Atp1b2 Atp1b1 Fkbp1b Ryr2 Kcnk18 Atp1a4 Atp1a1 Atp1a2 Atp1a3 TBC RABGAPS%REACTOME DATABASE ID RELEASE 66%10146222 TBC RABGAPs Rab6b Rabgap1 Rab35 Rab7a Ulk1 Rab8a Rab8b Gabarapl2 Tsc1 Tbc1d10a Tbc1d10b Rab11a Arf6 Rab6a Tsc2 Rab7b Tbc1d13 Tbc1d16 Tbc1d15 Tbc1d17 Sytl1 Rab33a Rab11b Rab33b Tbc1d2 Tbc1d7 Optn Tbc1d25 Tbc1d10c Gabarap Rab4a Tbc1d14 FBXL7 DOWN-REGULATES AURKA DURING MITOTIC ENTRY AND IN EARLY MITOSIS%REACTOME%R-RNO-8854050.1 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis Psmc6 Psmb10 G6pc Psmb8 Psmb9 Psmb4 Psmb11 Fbxl18 Psmb5 Fbxl7 Psmf1 Psmb6 Psmd4 Psmb2 Rbx1 Cul1 Psmd5 Psmd8 Psmb7 Psmd9 Psmb1 Psmb3 Psma8 Skp1 Psmd11 Psmd12 Psmd13 Aurka Psmd14 Psma5 Psma2 Psmc5 Psmc3 Psmd2 Psma1 Psma4 Psmc1 Psma3 Psmc4 Psmc2 Psma6 Psme1 Psmd1 Psme2 Psmd7 LOC100909844 Psmd3 Psmd6 COPI-INDEPENDENT GOLGI-TO-ER RETROGRADE TRAFFIC%REACTOME%R-RNO-6811436.1 COPI-independent Golgi-to-ER retrograde traffic Dctn1 Dctn2 Pla2g6 Dync1li2 Rab6b Dctn3 Dync1i2 Rab18 Rab3gap2 Pla2g4a Bicd2 Bicd1 Capzb Actr10 Dync1h1 Pafah1b1 Agpat3 Dync1li1 Capza2 Capza3 Rab6a Dynll2 Dctn5 Dctn6 Dync1i1 Dctn4 Galnt1 Actr1a Pafah1b3 Galnt2 TANDEM PORE DOMAIN HALOTHANE-INHIBITED K+ CHANNEL (THIK)%REACTOME DATABASE ID RELEASE 66%10145843 Tandem pore domain halothane-inhibited K+ channel (THIK) Kcnk13 PYROPHOSPHATE HYDROLYSIS%REACTOME%R-RNO-71737.1 Pyrophosphate hydrolysis Sar1a Ppa2 MITOPHAGY%REACTOME DATABASE ID RELEASE 66%10146046 Mitophagy Csnk2b Src Vdac1 Pgam5 Fundc1 Mfn1 Mfn2 LOC100911485 Tomm6 Csnk2a2 Tomm70a Tomm7 Tomm40 Ulk1 Sqstm1 Atg12 Map1lc3a Pink1 Mterfd1 Csnk2a1 Tomm20 Tomm22 LYSOSOMAL OLIGOSACCHARIDE CATABOLISM%REACTOME DATABASE ID RELEASE 66%10146170 Lysosomal oligosaccharide catabolism Man2b1 Manba Man2c1 POTASSIUM CHANNELS%REACTOME%R-RNO-1296071.1 Potassium Channels Kcng4 Kcng3 Kcnq2 Kcna7 Kcnb2 Kcns2 Kcnq3 Kcns1 Kcnh4 Kcnmb4 Kcnh3 Kcnmb3 Kcnh2 Kcnn2 Kcnab3 Kcnn3 Kcna10 Kcnf1 Kcnh6 Kcnmb2 Kcnh5 Kcnmb1 Kcnd3 Kcnn4 Kcnn1 Kcnd1 Kcnma1 Kcna1 Kcna2 Kcna5 Kcnc3 Kcnh1 Kcna4 Hcn1 Hcn3 Kcnk16 Hcn2 Kcnj2 Kcnj3 Kcnj11 Kcnj14 Kcnk1 Kcnj15 Kcnj9 Kcnk13 Abcc8 Kcnk2 Kcnk3 Kcnj5 LOC100909725 Kcnj8 Gabbr1 Kcnk4 Kcnj12 Kcnk10 Gabbr2 Kcnk9 Gng10 Abcc9 Kcnj4 Kcnj6 Kcnk6 Kcnk7 Kcnab2 Kcnj16 Gnb3 Kcnc2 Gnb2 Gnb1 Kcnk18 Kcnv2 Gng12 Kcnv1 Kcns3 Kcnq1 Gng4 Gngt2 Gng5 Gngt1 Gng8 Gng3 PI3K CASCADE%REACTOME DATABASE ID RELEASE 66%10144954 PI3K Cascade Pik3r1 Pik3r2 Fgf23 Fgf22 Fgf4 Fgf1 Fgf3 Tlr9 Fgf6 Fgf5 Fgf20 Gab1 Pde3b Fgf16 Pik3c3 Fgf17 Irs2 Fgf10 Fgf9 Fgfr2 Fgf7 Fgf2 Fgf8 Fgfr3 Pik3r4 Trib3 Pdpk1 Fgfr1 Fgfr4 Pik3cb Ptpn11 Fgf19 Them4 Irs1 Frs2 Akt2 Grb2 BREAKDOWN OF THE NUCLEAR LAMINA%REACTOME%R-RNO-352238.1 Breakdown of the nuclear lamina Casp6 Lmnb1 Lmna ACTIVATION, TRANSLOCATION AND OLIGOMERIZATION OF BAX%REACTOME DATABASE ID RELEASE 66%10145017 Activation, translocation and oligomerization of BAX Bax Bid ENDOSOMAL VACUOLAR PATHWAY%REACTOME%R-RNO-1236977.1 Endosomal Vacuolar pathway RT1-CE2 RT1-CE3 RT1-CE4 RT1-A2 RT1-CE7 RT1-M3-1 RT1-CE5 RT1-A1 B2m RT1-M6-1 LOC683761 RT1-CE10 LOC100364956 RT1-M2 RT1-M6-2 LOC100364500 RT1-M5 RT1-M4 RT1-S3 RT1-A ABACAVIR METABOLISM%REACTOME%R-RNO-2161541.1 Abacavir metabolism Nt5c2 Adal Adh6 PROTEIN FOLDING%REACTOME%R-RNO-391251.1 Protein folding Cct6b Gnai3 Rgs9 Csnk2a2 Gnat3 Gnao1 Cct6a Csnk2a1 Tcp1 Cct7 Rgs7 Cct4 Gnat2 Pdcl Gnaz Cct3 Csnk2b Gnai2 Gnb3 Gnb5 Cct2 Gnb2 Gnb1 Gng13 Gng12 Gng11 Gnat1 Cct8 LOC100912034 Gnb4 Gng4 Gngt2 Gnai1 Gng5 Gngt1 Gng10 Gng8 Gng3 ACTIVATION OF BIM AND TRANSLOCATION TO MITOCHONDRIA%REACTOME DATABASE ID RELEASE 66%10145048 Activation of BIM and translocation to mitochondria Mapk8 Bcl2l11 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION%REACTOME%R-RNO-399955.1 SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion Pip5k1c Plxna2 Fyn Plxna1 Tln1 Nrp1 Sema3a Farp2 SIGNALING BY NTRKS%REACTOME%R-RNO-166520.1 Signaling by NTRKs Dusp3 Dusp4 Rac1 Vrk3 Rps6ka2 Rps6ka1 Rps6ka3 Rps6ka5 LOC100912585 Dusp7 Dusp6 Atf1 Furin Gab1 Ap2a2 Irs2 Dnal4 Hgf Ralgds Kidins220 Sh3gl2 Irs1 Frs2 Kras Src Pik3r1 Pik3r2 Shc2 Dock7 Cltc Clta Ntrk1 Ngf Ppp2cb Ntf4 Ppp2ca Ntrk2 Bdnf Ppp2r1a Ap2s1 Ap2a1 Ap2m1 Shc3 Mapk7 Crk Rap1a Ppp2r1b Mapkapk3 Mapkapk2 Mapk1 Pik3cb Rhoa Creb1 Plcg1 Crkl Hras Pcsk6 Ntrk3 Nras Ntf3 Sos1 Mapk14 Rapgef1 Shc1 Pcsk5 Mapk11 Grb2 LOC100911248 HUR (ELAVL1) BINDS AND STABILIZES MRNA%REACTOME DATABASE ID RELEASE 66%10145693 HuR (ELAVL1) binds and stabilizes mRNA Prkcd RGD1563307 Xpo1 Prkca Elavl1 Anp32a Tnfsf13 INTESTINAL LIPID ABSORPTION%REACTOME DATABASE ID RELEASE 66%10145460 Intestinal lipid absorption Npc1l1 RNA POLYMERASE I PROMOTER OPENING%REACTOME DATABASE ID RELEASE 66%10144847 RNA Polymerase I Promoter Opening LOC100910200 H2afx Hist1h4b LOC684841 Hist1h2bh LOC100912290 Hist1h2ail1 Hist1h4m LOC102549173 LOC103690002 LOC100910152 LOC100912338 Ubtf Hist1h3c H2afb3 Hist1h3f Hist2h4 LOC684819 Hist1h3a H2afj Hist2h2aa3 Hist1h2bq Hist2h2aa2 LOC100364835 LOC684762 Hist1h2bo Hist1h2bcl1 Hist2h3c2 Hist1h2bk H3f3b Hist1h2bg Mbd2 LOC680097 LOC684797 LOC100912418 Hist1h2ba Hist3h2bb INTEGRIN CELL SURFACE INTERACTIONS%REACTOME%R-RNO-216083.1 Integrin cell surface interactions Cd44 Ibsp Itgam Itgae Itgb6 Itgb7 Itgb8 Madcam1 Itgb2 Itga4 Vtn Itga6 Jam3 Itga8 Fbn1 Col16a1 Cd47 Col9a1 Col9a2 Col9a3 Col4a1 Fgb Fgg Thbs1 Col4a2 Col4a3 Fga Itgal Itgax Spp1 Icam4 Icam5 Bsg Col13a1 Icam1 Vcam1 Lum F11r Comp Itga10 Itga11 Cdh1 Fn1 LOC100909977 Col18a1 Kdr Itga3 LOC100911572 Itga2b Icam2 TNFR2 NON-CANONICAL NF-KB PATHWAY%REACTOME DATABASE ID RELEASE 66%10145373 TNFR2 non-canonical NF-kB pathway Psmc6 Psmb10 Psmb8 Psmb9 Psmb4 Cd40 Psmb11 Psmb5 Psmf1 Psmb6 Psmd4 Psmb2 Cul1 Psmd5 Psmd8 Psmd9 Psmb3 Psma8 Psmd11 Psmd12 Psmd13 Psmd14 Tnf Cd40lg Ube2m Traf3 Psmc3 Tnfsf13b Tnfrsf9 Birc3 Tnfrsf8 Birc2 Edaradd G6pc Tnfrsf4 Eda2r Cd70 Tnfrsf17 Tnfsf8 Tnfrsf14 Tnfsf9 Tnfrsf25 Edar Psmb7 Prmt2 Tnfrsf11b Psmb1 Tnfrsf11a Tnfsf4 Tnfsf14 Tnfsf12 Skp1 Tnfrsf12a Tnfrsf13c Eda Tnfsf11 Lta Ltb Ltbr Cd27 Nfkb2 Psma5 Fbxw11 Tnfrsf1b Chuk Btrc Psma2 Psmc5 Psma1 Psmd2 Traf2 Uba3 Psma4 Map3k14 Psmc1 Relb Psma3 Psmc4 Psma6 Psmc2 Psme1 Psme2 Psmd1 Psmd7 Psmd3 Tnfsf13 Psmd6 N-GLYCAN TRIMMING AND ELONGATION IN THE CIS-GOLGI%REACTOME DATABASE ID RELEASE 66%10145771 N-glycan trimming and elongation in the cis-Golgi Man1c1 Manea Man1a2 Man1a1 Mgat1 FRS-MEDIATED FGFR4 SIGNALING%REACTOME DATABASE ID RELEASE 66%10146106 FRS-mediated FGFR4 signaling Kras Frs3 Fgf23 Fgf22 Fgf4 Fgf1 Fgf3 Fgf6 Fgf5 Fgf20 Fgf16 Fgf17 Fgf10 Fgf9 Fgfr2 Fgf7 Fgf2 Fgf8 Fgfr3 Fgfr1 Fgfr4 Ptpn11 Fgf19 Hras Nras Sos1 Frs2 Grb2 G-PROTEIN ACTIVATION%REACTOME%R-RNO-202040.1 G-protein activation Gnai3 Pomc Gnat3 Pdyn Gnao1 Gnat2 Gnaz Gnai2 Gnb3 Gnb5 Oprm1 Gnb2 Gnb1 Gng13 Gng12 Gng11 Gnat1 LOC100912034 Gnb4 Gng4 Gnai1 Gngt2 Gng5 Gngt1 Gng10 Gng8 Gng3 OXIDATIVE STRESS INDUCED SENESCENCE%REACTOME DATABASE ID RELEASE 66%10145165 Oxidative Stress Induced Senescence Map2k7 Map2k6 Mdm2 Map2k4 Tnik Mink1 Map3k5 Hist1h2bo Hist1h2bcl1 Scmh1 Hist2h3c2 Cbx4 Hist1h2bk Cbx2 H3f3b Cbx8 Cbx6 Bmi1 Rnf2 Kdm6b Ring1 Phc3 Mapkapk5 Cdkn2b Cdkn2c Cdk6 Eed LOC100910200 H2afx Hist1h4b LOC684841 Hist1h2bh LOC100912290 Rbbp7 Hist1h2ail1 Hist1h4m Cdk4 LOC102549173 LOC103690002 LOC100910152 LOC100912338 Hist1h3c Jun H2afb3 Hist1h3f Hist2h4 LOC684819 Hist1h3a H2afj Hist2h2aa3 Hist1h2bq Hist2h2aa2 LOC100364835 Phc1 LOC684762 Phc2 Mapk9 Mapk8 Fos LOC100910954 Txn1 Mdm4 Mapkapk3 Map4k4 Mapkapk2 Mapk1 Hist1h2bg Ezh2 LOC680097 LOC684797 Mapk14 LOC100912418 Hist1h2ba Hist3h2bb Mapk11 Mapk10 TACHYKININ RECEPTORS BIND TACHYKININS%REACTOME DATABASE ID RELEASE 66%10145521 Tachykinin receptors bind tachykinins Tacr3 Tacr2 Tac3 Tacr1 Tac1 GLOBAL GENOME NUCLEOTIDE EXCISION REPAIR (GG-NER)%REACTOME%R-RNO-5696399.1 Global Genome Nucleotide Excision Repair (GG-NER) Rfc1 Rfc2 Gtf2h1 Gtf2h2 Ddb2 Pole2 Pole4 Pias3 Pias1 Yy1 Ddb1 Mnat1 Rbx1 Actr8 Chd1l Actl6a Mcrs1 Cops8 Cops2 Actb Sumo1 Rpa3 Pole Sumo3 Ino80 Pcna Cul4b Ccnh Cul4a Ube2v2 Xpc Ube2n Xpa Ube2i Ruvbl1 Gtf2h3 Rfc5 Rfc4 Rfc3 Gtf2h5 Gtf2h4 Ercc5 Ercc3 Rpa1 Rpa2 Cops4 Cops6 Ercc2 Ercc1 Cops3 Ino80e Ino80d Nfrkb Usp45 Parp2 Parp1 Rad23a Cdk7 Rad23b Cops7b Cops7a Pold2 Pold1 Pold4 Ino80b Ino80c CENTROSOME MATURATION%REACTOME%R-RNO-380287.1 Centrosome maturation Dync1i2 Tubgcp2 Cep57 LOC691918 Haus3 Ninl Akap9 Ccp110 Dync1h1 Pafah1b1 LOC103692716 Dctn1 Cntrl Dctn2 Cep76 Pcm1 Cep78 LOC100911033 Cep164 Dctn3 Cep41 Ofd1 Sdccag8 Tubb5 Prkar2b Cenpj Ywhag Ppp2r1a Plk4 Ywhae LOC100912076 Tubg2 Haus2 Haus1 Haus5 Alms1 Cdk11b Haus4 Clasp1 Odf2 Tubb4a Cdk1 Nek2l1 Ssna1 Mapre1 Tubg1 Cep63 Prkaca Csnk1d Cep131 Tuba4a Cep250 Cep135 Csnk1e Ckap5 Cdk5rap2 Nme7 Tubgcp5 Pcnt Nek2 Tubgcp6 Cep72 Tubgcp3 Sfi1 Tubgcp4 Cep70 Actr1a Mzt1 Nedd1 Mzt2b CHROMATIN ORGANIZATION%REACTOME DATABASE ID RELEASE 66%10145803 Chromatin organization Kdm1a Phf20 Actl6a Mcrs1 Rps2 Setd6 Setd7 Setd8 Setd2 Setd3 Ash1l Suv39h1l1 Rbbp5 Jmjd6 Actl6b Hist1h2aa Smarce1 Pax3 Pbrm1 Arid1b Arid1a Cdk4 Brwd1 Smarcd1 Msl3l2 Smarcd2 Smarcd3 Brpf3 Ccnd1 Kdm2a Brpf1 Brd1 Kdm1b LOC100911453 RGD1310212 Wdr77 Kat6a Ing4 Ing5 Nfkb2 Nfkb1 Prmt3 Padi6 Prmt5 Prmt6 Prmt7 Rela Atf2 Hist1h2bo Kat7 Kansl3 Hist1h2bcl1 Hist2h3c2 Jade1 Hist1h2bk Jade3 Hat1 Kdm4b Carm1 Kdm4a Jade2 Kdm4d Kdm5a Kdm6b Kdm5d Smarca4 Kdm4dl1 Prmt1 Smarca2 LOC100911617 Kat8 Kdm8 Msl3 Kdm3b Kdm3a Arid2 Ogt Smarcc1 Smarcc2 Padi3 Coprs Smarcb1 Padi4 Msl1 Padi1 Ncoa1 Msl2 Meaf6 LOC100909949 Eed Whsc1 LOC100910200 Atf7ip H2afx Hist1h4b Prdm9 Wdr5 Kmt2a LOC684841 Hist1h2bh Smyd2 Setdb1 LOC100911180 LOC100912290 Suv420h2 Rbbp7 LOC686349 Hist1h2ail1 Suv420h1 Hist1h4m LOC102549173 Mecom LOC103690002 Ehmt2 LOC100910152 Whsc1l1 Dnmt3a Ehmt1 LOC100912338 Hist1h3c H2afb3 Hist1h3f Hist2h4 LOC684819 Hist1h3a H2afj Prdm16 Nsd1 Hist2h2aa3 Suv39h1 Hist1h2bq Suv39h2 Hist2h2aa2 LOC100910833 Ash2l Dot1l LOC100364835 Dpy30 LOC684762 Padi2 Ncoa2 Hist1h2bg Ezh2 LOC680097 LOC684797 LOC100912418 Hist1h2ba Hist3h2bb Aebp2 EXTENSION OF TELOMERES%REACTOME DATABASE ID RELEASE 66%10145111 Extension of Telomeres Rfc1 Rfc2 Rpa3 Pole2 Pole4 LOC100911727 Pole Pold2 Tert Pcna Pold1 Pold4 Rpa1 Slc25a16 Rpa2 Fen1 Prim2 Pola2 Prim1 Rfc5 Rfc4 Rfc3 Lig1 CDO IN MYOGENESIS%REACTOME DATABASE ID RELEASE 66%10145503 CDO in myogenesis Cdh2 Ctnna1 Myf5 LOC100909750 Myf6 Mapk12 Tcf4 Cdon Myog Cdc42 Boc Myod1 Mef2c Spag9 Cdh15 Mapk14 Mef2a Mapk11 Abl1 GAP JUNCTION TRAFFICKING AND REGULATION%REACTOME DATABASE ID RELEASE 66%10145298 Gap junction trafficking and regulation Gja1 Src Gja5 Dnm1 Gjd4 Gja3 Gja8 Gja4 Gjb6 Gjb2 Cltc Gja10 Cltb Gjd2 Gjb3 Clta Dnm2 Gjb4 Gjc1 Gjc2 Gjb1 Myo6 Dab2 Ap2m1 GLUTATHIONE SYNTHESIS AND RECYCLING%REACTOME%R-RNO-174403.1 Glutathione synthesis and recycling Ggct Gclm Cndp2 Gclc Ggt7 Ggt6 Chac2 Gss Chac1 Oplah INTERLEUKIN-3, INTERLEUKIN-5 AND GM-CSF SIGNALING%REACTOME DATABASE ID RELEASE 66%10145705 Interleukin-3, Interleukin-5 and GM-CSF signaling Stat5a Jak3 Csf2ra Csf2rb Il2rg Pik3r3 Pik3r1 Jak1 Pik3r2 Il5ra Inpp5d Ywhaz Pik3cd Vav1 Fyn Crk Cbl Prkaca Pik3cb Il5 Ptpn11 Tec Il2 Ptpn6 Lyn Il2ra Csf2 Crkl Il3ra Yes1 Sos1 Hck Rapgef1 Shc1 Syk Grb2 LOC100911248 Il2rb ACYL CHAIN REMODELLING OF PC%REACTOME%R-RNO-1482788.1 Acyl chain remodelling of PC Pla2r1 Pla2g6 Pla2g3 Pla2g5 Pla2g4e Pla2g4b Pla2g4d Pla2g16 Pla2g2a Pla2g2f Pla2g10 Pla2g2d Pla2g1b LOC686302 Pla2g4a Pla2g12a Pla2g4c Lpcat4 Lpcat1 Plbd1 Pnpla8 Lpcat3 Lpcat2 Tmem86b Pla2g4cl1 INTERLEUKIN-1 SIGNALING%REACTOME%R-RNO-9020702.1 Interleukin-1 signaling Ripk2 Psmc6 Map2k6 Ager Psmb10 Psmb8 Map3k8 Psmb9 Psmb4 Peli3 Nfkbib Psmb11 Psmb5 Psmf1 Peli2 Psmb6 Traf6 Psmd4 Psmb2 Cul1 Rbx1 Psmd5 Psmd8 Psmd9 Psmb3 App Psma8 Psmd11 Psmd12 Tab1 Psmd13 Rela Psmd14 Map3k7 Peli1 Irak2 Il1rap Psmc3 Sqstm1 Nfkbia Il1b LOC100910771 Ube2n Irak3 Il1r1 Map3k3 G6pc Psmb7 Psmb1 Skp1 Il1a Nfkb2 Nfkb1 Psma5 S100b Irak4 Dhx9 Fbxw11 Chuk Tollip Btrc Psma2 Psmc5 Nkiras1 Psma1 LOC100362142 Psmd2 Psma4 Nod1 Nod2 Psmc1 Psma3 Nkiras2 Psmc4 Psma6 Psmc2 Tab2 Psme1 Tab3 LOC100912618 Ube2v1 Psme2 Psmd1 Ikbkb Psmd7 Myd88 Tnip2 Psmd3 Psmd6 G0 AND EARLY G1%REACTOME%R-RNO-1538133.1 G0 and Early G1 Rbl2 Cdk2 E2f5 Rbl1 Lin9 Hdac1l E2f4 Hdac1 Dyrk1a Lin37 Lin52 Lin54 Ccna2 Ccne2 Ccna1 Ccne1 Tfdp1 Tfdp2 ACTIVATION OF CAMK IV%REACTOME%R-RNO-442745.1 Activation of CaMK IV Camk4 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%R-RNO-1296041.1 Activation of G protein gated Potassium channels Kcnj4 Kcnj6 Kcnj16 Gnb3 Gnb2 Gnb1 Gng12 Kcnj2 Kcnj3 Kcnj15 Kcnj9 Kcnj5 Gng4 Gngt2 Gabbr1 Gng5 Kcnj12 Gngt1 Gng10 Gng8 Gabbr2 Gng3 DUAL INCISION IN TC-NER%REACTOME%R-RNO-6782135.1 Dual incision in TC-NER Rfc1 Rfc2 Gtf2h1 Gtf2h2 Usp7 Pole2 Pole4 Ppie Ddb1 Mnat1 Rbx1 RGD1565904 Isy1 Polr2g Polr2h Polr2e Polr2f Polr2j Polr2k Polr2d Polr2i Polr2b Polr2c Polr2a Xab2 LOC100912534 Rpa3 Zfp830 Pole Prpf19 Tcea1 Pcna Cul4b Uvssa Ccnh Cul4a Hmgn1 Xpa Gtf2h3 Rfc5 Rfc4 Rfc3 Gtf2h5 Gtf2h4 Ercc5 Ercc8 Ercc3 Ercc6 Rpa1 Rpa2 LOC100911295 LOC100911822 Aqr Ercc2 Ercc1 Cdk7 Pold2 Pold1 Pold4 CYTOSOLIC TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 66%10144822 Cytosolic tRNA aminoacylation Sar1a ELECTRON TRANSPORT FROM NADPH TO FERREDOXIN%REACTOME%R-RNO-2395516.1 Electron transport from NADPH to Ferredoxin Fdx1l Fdxr Fdx1 VEGF LIGAND-RECEPTOR INTERACTIONS%REACTOME DATABASE ID RELEASE 66%10145339 VEGF ligand-receptor interactions Vegfa Flt4 LOC100911280 Kdr Flt1 Figf Vegfc Vegfb Pgf YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION%REACTOME%R-RNO-2032785.1 YAP1- and WWTR1 (TAZ)-stimulated gene expression Yap1 Tbx5 Tead2 Tead1 Wwtr1 DNA REPAIR%REACTOME DATABASE ID RELEASE 66%10144763 DNA Repair Rfc1 Rfc2 Gtf2h1 Gtf2h2 Usp7 Ddb2 Pole2 Pole4 Pias3 Polh Pias1 Spidr Ppie Eme2 Yy1 Eme1 Ddb1 Polq Mnat1 Rtel1 Ppp4r2 Rbx1 RGD1565904 Ppp4c Actr8 Isy1 Uba7 Polr2g Polr2h Polr2e Polr2f Polr2j Polr2k Pias4 Polr2d Polr2i Ube2l6 Polr2b Polr2c Chd1l Uimc1 Polr2a Actl6a Mcrs1 Xab2 Cops8 LOC100912534 Cops2 LOC100909750 Actb Sumo1 Rpa3 Lig3 Zfp830 Pole Prpf19 Sumo3 Ino80 Tcea1 Pcna Cul4b Xrcc3 Brca1 Uvssa Blm Ccnh Slx4 Mdc1 Cul4a Mus81 Ube2v2 Hmgn1 Slx1b Palb2 Xpc Sirt6 Ube2n Pms2 Gen1 Xpa Mlh1 Ube2i Msh6 Ruvbl1 Gtf2h3 Rfc5 Rfc4 Rfc3 Gtf2h5 Gtf2h4 Tp53bp1 Rad52 Ercc5 Herc2 Ercc8 Xrcc4 Ercc3 Ercc6 Rpa1 Rpa2 LOC100911295 LOC100911822 Cops4 Rchy1 Aqr Cops6 Ercc2 Ercc1 Lig1 Cops3 Slc25a16 Fen1 Sprtn Nploc4 Ns5atp9 Zbtb32 Poli Usp43 Rev1 Xrcc6 Xrcc5 Usp10 Ufd1l Abl1 Ino80e Ino80d Nfrkb Usp45 Xrcc1 Parp2 Parp1 Rad23a LOC100911727 Cdk7 Rad23b Cops7b Cops7a Pold2 Pold1 Pold4 Tdp2 Lig4 Paxip1 Polm Nhej1 Prkdc Dclre1c Poll Ino80b Ino80c Rhno1 Msh3 Bard1 Msh2 Wrn Topbp1 Rbbp8 Rmi1 Rmi2 Rad51c LOC100911267 Ppp5c Rad51d Rad51 Wdr48 Brca2 Rad50 Bre Brcc3 Ccna2 Ccna1 Dtl Atm Atrip Cdk2 Rad18 RGD1564719 RGD1306926 Fance Fanca Fancf Ube2t Fancc Fancb Rad1 Fancl Atr Fanci Bap1 Usp1 Poln Dclre1a Rad17 Fan1 Xrcc2 Rad9a Nbn Rad9b Mre11a LOC100359600 Hus1 Babam1 Mapk8 Mad2l2 Rev3l Kpna2 Vcp Hist1h2bo Tdg Mpg Hist1h2bcl1 Neil1 Hist1h2bk Ogg1 Neil2 Kdm4b Mbd4 Kdm4a Smug1 Pnkp Polb Nthl1 Mutyh Isg15 Trim25 Adprhl2 Ung Smarca5 Parg Apex1 LOC100910200 Whsc1 H2afx Fto Alkbh5 Hist1h4b Rnf8 Hist1h2bh LOC100912290 Eya3 Apbb1 LOC686349 Eya2 Hist1h4m Eya4 LOC100912338 Hist2h4 Hist1h2bq LOC100364835 Baz1b Fam175a LOC100910954 Chek2 Hist1h2bg LOC680097 LOC684797 LOC100912418 Hist1h2ba Hist3h2bb REGULATION OF NECROPTOTIC CELL DEATH%REACTOME DATABASE ID RELEASE 66%10146017 Regulation of necroptotic cell death Faslg Traf2 Cflar Fadd Birc3 Birc2 Ripk1 Xiap Tradd Tnfsf10 Casp8 Fas INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1%REACTOME DATABASE ID RELEASE 66%10145013 Inhibition of replication initiation of damaged DNA by RB1 E2F1 Ppp2cb Ppp2ca Ppp2r3b Ppp2r1a Rb1 Prim2 Pola2 Ppp2r1b Prim1 RECOGNITION OF DNA DAMAGE BY PCNA-CONTAINING REPLICATION COMPLEX%REACTOME DATABASE ID RELEASE 66%10146094 Recognition of DNA damage by PCNA-containing replication complex Rfc1 Rfc2 Rpa3 Pole2 Pole4 Rad18 Pole Wdr48 Ddb1 Pold2 Rbx1 Pcna Pold1 Cul4b Pold4 Zbtb32 Usp1 Cul4a Rpa1 Rpa2 Rfc5 Rfc4 Dtl Rfc3 SYNAPTIC ADHESION-LIKE MOLECULES%REACTOME DATABASE ID RELEASE 66%10146209 Synaptic adhesion-like molecules Grin2d Ptprd Grin2b Grin1 Dlg1 Gria3 Gria4 Flot1 Flot2 Rtn3 Dlg3 Ptprf Lrfn2 Lrfn3 Lrfn1 Lrfn4 Dlg4 VEGF BINDS TO VEGFR LEADING TO RECEPTOR DIMERIZATION%REACTOME DATABASE ID RELEASE 66%10145338 VEGF binds to VEGFR leading to receptor dimerization Vegfa Flt4 LOC100911280 Kdr Flt1 Figf Vegfc Vegfb Pgf THE ACTIVATION OF ARYLSULFATASES%REACTOME DATABASE ID RELEASE 66%10145887 The activation of arylsulfatases Arsi Arse Arsg Arsk Sts Arsb Arsa Sumf2 Sumf1 LINOLEIC ACID (LA) METABOLISM%REACTOME DATABASE ID RELEASE 66%10145933 Linoleic acid (LA) metabolism Acsl1 Fads1 Elovl1 Elovl5 Elovl2 Elovl3 Abcd1 FORMATION OF ANNULAR GAP JUNCTIONS%REACTOME%R-RNO-196025.1 Formation of annular gap junctions Cltb Clta Gja1 Dnm2 Dnm1 Dab2 Ap2m1 Cltc CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM%REACTOME DATABASE ID RELEASE 66%10145886 Chondroitin sulfate dermatan sulfate metabolism Ncan Agrn Hexb Hexa Xylt2 Chst7 Chst9 Chst12 Chst11 Dcn B3gat1 B3gat3 Csgalnact1 Csgalnact2 B3gat2 Chst13 LOC102550316 Chst3 Hyal1 Cspg5 Cspg4 Sdc2 Sdc3 Idua Sdc4 Ust Chst15 Chst14 Dsel Gpc6 Bcan Vcan Chpf2 Chsy1 Dse Gpc4 Gpc2 Arsb LOC100910284 B4galt7 Gpc1 Chpf B3galt6 INTERLEUKIN-12 FAMILY SIGNALING%REACTOME%R-RNO-447115.1 Interleukin-12 family signaling P4hb Il23a Crlf1 Stat1 Il6st Jak1 Stat3 Il12rb1 Il12rb2 Il12b Canx Il12a Il23r Tyk2 Ebi3 Vamp7 Il27ra TOLL LIKE RECEPTOR 10 (TLR10) CASCADE%REACTOME%R-RNO-168142.1 Toll Like Receptor 10 (TLR10) Cascade Map2k7 Ripk2 Map2k6 Ager Dusp3 Map2k4 Map3k8 Dusp4 Peli3 Nfkbib LOC100912399 Peli2 Map3k1 Traf6 Cul1 Vrk3 Rps6ka2 Rps6ka1 App Rps6ka3 Rps6ka5 LOC100912585 Tab1 Dusp7 Dusp6 Rela Atf1 Atf2 Map3k7 Peli1 Irak2 Nfkbia LOC100910771 Ube2n Jun Ppp2cb Ppp2ca Skp1 Ppp2r1a Nfkb2 Nfkb1 Mapk9 Mapk8 Fos S100b Mapk7 Dhx9 Fbxw11 Chuk Ppp2r1b Ecsit Mapkapk3 Btrc Mapkapk2 Mapk1 Nkiras1 LOC100362142 Nod1 Nod2 Nkiras2 Creb1 Tab2 Tab3 LOC100912618 Ube2v1 Ikbkb Mapk14 Myd88 Tnip2 Mapk11 Mapk10 BIOSYNTHESIS OF ASPIRIN-TRIGGERED D-SERIES RESOLVINS%REACTOME%R-RNO-9020265.1 Biosynthesis of aspirin-triggered D-series resolvins Gpx4 Alox5 Lta4h ADENYLATE CYCLASE INHIBITORY PATHWAY%REACTOME DATABASE ID RELEASE 66%10145186 Adenylate cyclase inhibitory pathway Gnat3 Adcy8 Adcy9 Gnai3 Adcy5 Adcy3 Adcy4 Gnai2 Adcy7 Adcy6 Gnal Gnai1 HYDROLYSIS OF LPC%REACTOME%R-RNO-1483115.1 Hydrolysis of LPC Pla2g4a LOC686302 Plbd1 Pla2g4c Pla2g4e Pla2g4b Pla2g4d Pla2g15 Pla2g4cl1 PRE-NOTCH EXPRESSION AND PROCESSING%REACTOME DATABASE ID RELEASE 66%10145916 Pre-NOTCH Expression and Processing Notch1 Prkci Tmed2 Notch2 Notch4 Elf3 Notch3 Furin CD22 MEDIATED BCR REGULATION%REACTOME DATABASE ID RELEASE 66%10146141 CD22 mediated BCR regulation Ptpn6 Cd79al Lyn Cd22 Cd79b Cd79a ACTIVATION OF NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%R-RNO-629602.1 Activation of Nicotinic Acetylcholine Receptors Chrnb4 Chrne Chrnd Chrna4 Chrna5 Chrna9 Chrna6 Chrnb2 Chrna7 Chrnb3 Chrna2 Chrna3 Chrna1 TRANSCRIPTION FROM MITOCHONDRIAL PROMOTERS%REACTOME DATABASE ID RELEASE 66%10145118 Transcription from mitochondrial promoters Polrmt Tfam Tfb2m Mterf DOPAMINE RECEPTORS%REACTOME%R-RNO-390651.1 Dopamine receptors Drd5 Drd1 Drd4 Drd2 SYNTHESIS OF EPOXY (EET) AND DIHYDROXYEICOSATRIENOIC ACIDS (DHET)%REACTOME DATABASE ID RELEASE 66%10145947 Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) Cyp2c7 Cyp1b1 LOC100361547 Cyp1a1 Ephx2 Cyp1a2 Cyp2j10 Cyp2c6v1 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK%REACTOME DATABASE ID RELEASE 66%10145383 Energy dependent regulation of mTOR by LKB1-AMPK Cab39l Lamtor3 RragB Strada Prkab1 Stradb Prkab2 Cab39 Mtor Rheb Prkag3 Lamtor2 Rptor Lamtor1 Lamtor4 Tsc1 Lamtor5 Mlst8 Prkaa1 Tsc2 Rraga Prkaa2 Rragc Rragd Slc38a9 BIOSYNTHESIS OF E-SERIES 18(S)-RESOLVINS%REACTOME%R-RNO-9018896.1 Biosynthesis of E-series 18(S)-resolvins Hpgd Gpx4 Alox5 Alox15 Lta4h SYNTHESIS OF PA%REACTOME DATABASE ID RELEASE 66%10144907 Synthesis of PA Ddhd2 Ddhd1 Pla2r1 Pld1 Pld2 Pla2g5 Pld6 Pla2g4b Pla2g4d Pla2g2a Pla2g2f Pla2g2d Pla2g10 Gpd1l Pla2g1b Pla2g4a Pla2g12a Fam73b Alppl2 Lpcat4 Agpat1 Alpp Agpat4 Lpcat1 Alpi Agpat3 Lipi Agpat9 Agpat6 Acp6 Agpat5 Gpd1 Gpam Gnpat Agpat2 Lclat1 Gpat2 Gpd2 NOSTRIN MEDIATED ENOS TRAFFICKING%REACTOME%R-RNO-203641.1 NOSTRIN mediated eNOS trafficking Nos3 Dnm2 Nostrin Wasl DEPYRIMIDINATION%REACTOME DATABASE ID RELEASE 66%10144972 Depyrimidination Tdg Neil1 Ogg1 Neil2 Mbd4 Smug1 Ung Nthl1 PHYSIOLOGICAL FACTORS%REACTOME%R-RNO-5578768.1 Physiological factors Npr2 Npr1 Nppc Nppa Corin JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1%REACTOME%R-RNO-450321.1 JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 Map2k7 Ripk2 Mapk9 Mapk8 Map2k4 Traf6 LOC100362142 Nod1 Nod2 LOC100910771 Tab2 Ube2n Tab3 Tab1 LOC100912618 Ube2v1 Map3k7 Mapk10 Irak2 DNA STRAND ELONGATION%REACTOME%R-RNO-69190.1 DNA strand elongation Rfc1 Rfc2 Rpa3 LOC100911727 Pold2 Pcna Pold1 Pold4 Rpa1 Slc25a16 Rpa2 Fen1 Prim2 Pola2 Prim1 Rfc5 Gins3 Rfc4 Gins4 Rfc3 Lig1 Gins1 Gins2 INTERFERON ALPHA BETA SIGNALING%REACTOME%R-RNO-909733.1 Interferon alpha beta signaling Irf9 Stat1 Jak1 Stat2 Ptpn1 Rnasel Abce1 Socs3 Socs1 Ifnar2 Ifna5 Ifna4 Ptpn11 LOC100912356 LOC100911527 Ifna11 Ptpn6 Usp18 LOC100912859 Ifnar1 RGD1560539 Ifna2 Ifnb1 LOC103690314 Tyk2 LOC100912314 Ifna16l1 RGD1565911 RGD1561827 TOLL-LIKE RECEPTOR CASCADES%REACTOME DATABASE ID RELEASE 66%10145131 Toll-like Receptor Cascades Cnpy3 Unc93b1 Tlr3 RGD1308751 Cts8l1 Ube2n Rbsn Lbp Ptpn4 Jun Ppp2cb Ppp2ca Skp1 Ppp2r1a Ticam2 Nfkb2 Nfkb1 Tlr7 MGC114246 Mapk9 Tlr8 Mapk8 Fos S100b Irak4 Mapk7 Dhx9 Fbxw11 Chuk Ppp2r1b Ecsit Eea1 Mapkapk3 Btrc Mapkapk2 Mapk1 Nkiras1 LOC100362142 Testin Nod1 Nod2 Nkiras2 Creb1 Tab2 Tab3 LOC100912618 Ube2v1 Ikbkb Mapk14 Myd88 Tnip2 Mapk11 Mapk10 Tlr2 Map2k7 Ripk2 Tbk1 Itgam Map2k6 Ager Dusp3 Irf3 Map2k4 Map3k8 Dusp4 Peli3 Nfkbib Lgmn LOC100912399 Peli2 Map3k1 Traf6 Cul1 Vrk3 Rps6ka2 Itgb2 Hsp90b1 Rps6ka1 App Rps6ka3 Rps6ka5 Bpi Tirap Tlr9 LOC100912585 Tab1 Dusp7 Dusp6 Rela Atf1 Atf2 Map3k7 Peli1 Irak2 Tlr4 Ikbke RGD1565355 Tank Traf3 LOC100364523 Apob Nfkbia LOC100910771 LOC685953 Cd36 Tlr6 Tlr10 Ctsb Ctsl Ctsm Ctsj RGD1564657 Ctsk Ctsq Ctsr Cd14 Pik3c3 Pik3r4 Dhx36 Ptpn11 Cts8 Cts7 RGD1564827 RESOLUTION OF SISTER CHROMATID COHESION%REACTOME DATABASE ID RELEASE 66%10145894 Resolution of Sister Chromatid Cohesion Cenpn Zwilch Cenpl Nup43 Cenpo Nup98 Nup133 Dync1li2 Nup107 Cenpt Cenpu Bub3 Bub1 Spdl1 Kntc1 Dync1i2 Mad1l1 LOC100910252 Stag1 Cenpk Cenph Nup37 Cenpi Pds5b Pds5a Cenpf Cdca5 Rad21 Cenpe Smc1a Cenpm Stag2 Ahctf1 Smc3 Ndel1 Cdca8 Dync1h1 Rcc2 Pafah1b1 Dync1li1 Rangap1 Mis12 Ppp1cc LOC100909468 Aurkb Dynll2 Ndc80 Sec13 Cenpc Xpo1 Cenpa Dync1i1 LOC100911204 Ranbp2 Spc24 Spc25 Hdac8 Birc5 Taok1 Itgb3bp Sgol2 Ppp2r5e Incenp Nsl1 B9d2 Cdc20 Kif2a Kif2c Kif2b Bub1b Kif18a Ppp2r5c Ppp2cb Ppp2r5a Ppp2ca Ppp2r1a Ppp2r5b Zwint Dsn1 Mad2l1 Nup85 Casc5 Clasp2 Ercc6l Nuf2 Clasp1 LOC679582 Ppp2r1b Cdk1 Mapre1 Pmf1 Ckap5 Ska2 Sgol1 Zw10 Ska1 GPVI-MEDIATED ACTIVATION CASCADE%REACTOME%R-RNO-114604.1 GPVI-mediated activation cascade Pik3r5 Pik3r1 Pik3r3 Pik3r2 Pik3r6 Rac1 Vav2 Vav1 Pik3cg Fyn Vav3 Fcer1g Pdpk1 G6b Cdc42 Pik3cb Ptpn11 Rhoa Ptpn6 Lat Rac2 Lyn Rhog Lcp2 Rhob Syk NADE MODULATES DEATH SIGNALLING%REACTOME DATABASE ID RELEASE 66%10145330 NADE modulates death signalling Ngf Casp3 Ngfr Casp2 Ngfrap1 Ywhae RHO GTPASES ACTIVATE RHOTEKIN AND RHOPHILINS%REACTOME DATABASE ID RELEASE 66%10146121 RHO GTPases Activate Rhotekin and Rhophilins Rtkn Tax1bp3 Rhoa Rhpn1 Rhpn2 Lin7b PROSTANOID LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145568 Prostanoid ligand receptors Ptger3 Ptgir Tbxa2r Ptgfr Ptgdrl Ptgdr Ptger2 Ptger1 Ptgdr2 PACKAGING OF TELOMERE ENDS%REACTOME%R-RNO-171306.1 Packaging Of Telomere Ends LOC100910200 H2afx Hist1h4b Hist1h2bh Acd LOC100912290 Pot1b Hist1h4m LOC103690002 LOC100910152 Pot1 LOC100912338 H2afb3 Hist2h4 H2afj Hist2h2aa3 Hist1h2bq Hist2h2aa2 LOC100364835 Hist1h2bo Tinf2 Hist1h2bcl1 Hist1h2bk Terf1 Terf2 Terf2ip Hist1h2bg LOC680097 LOC684797 LOC100912418 Hist1h2ba Hist3h2bb ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING%REACTOME DATABASE ID RELEASE 66%10145740 Advanced glycosylation endproduct receptor signaling App Ager S100b Capza2 TP53 REGULATES TRANSCRIPTION OF CELL DEATH GENES%REACTOME%R-RNO-5633008.1 TP53 Regulates Transcription of Cell Death Genes Triap1 Zfp420 LOC100911519 Chm Rabggta Prelid1 Rabggtb Cradd Bnip3l Slmo1 Pidd1 LOC100910137 Casp2 Atm FGFR2C LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 66%10145288 FGFR2c ligand binding and activation Fgf23 Fgf4 Fgf1 Fgf16 Fgf17 Fgf6 Fgf5 Fgf9 Fgfr2 Fgf2 Fgf8 Fgf20 PLASMA LIPOPROTEIN ASSEMBLY%REACTOME%R-RNO-8963898.1 Plasma lipoprotein assembly P4hb A2m Abca1 Zdhhc8 Prkaca Prkacb Sar1b Bmp1 Apoa1 Apob Apoc2 Apoe Apoc1 Apoa2 LOC100910181 Mttp Apoc4 ACTIVATED NTRK2 SIGNALS THROUGH FRS2 AND FRS3%REACTOME%R-RNO-9028731.1 Activated NTRK2 signals through FRS2 and FRS3 Ntf4 Ntrk2 Bdnf Frs2 Sos1 Grb2 E2F MEDIATED REGULATION OF DNA REPLICATION%REACTOME DATABASE ID RELEASE 66%10145014 E2F mediated regulation of DNA replication Ppp2cb Ppp2ca Ppp2r3b Ppp2r1a Rb1 Prim2 Pola2 Ppp2r1b Prim1 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE%REACTOME%R-RNO-181438.1 Toll Like Receptor 2 (TLR2) Cascade Map2k7 Ripk2 Map2k6 Ager Dusp3 Map2k4 Map3k8 Dusp4 Peli3 Nfkbib LOC100912399 Peli2 Map3k1 Traf6 Cul1 Vrk3 Rps6ka2 Rps6ka1 App Rps6ka3 Rps6ka5 Tirap LOC100912585 Tab1 Dusp7 Dusp6 Rela Atf1 Atf2 Map3k7 Peli1 Irak2 Nfkbia LOC100910771 Ube2n Jun Ppp2cb Ppp2ca Skp1 Ppp2r1a Nfkb2 Nfkb1 Mapk9 Mapk8 Fos S100b Mapk7 Dhx9 Fbxw11 Chuk Ppp2r1b Ecsit Mapkapk3 Btrc Mapkapk2 Mapk1 Nkiras1 LOC100362142 Nod1 Nod2 Nkiras2 Creb1 Tab2 Tab3 LOC100912618 Ube2v1 Ikbkb Mapk14 Myd88 Tnip2 Mapk11 Mapk10 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION%REACTOME%R-RNO-1474151.1 Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation Nos3 Pts Spr Prkg2 LOC103692716 Akt1 Gch1 Gchfr RHO GTPASES ACTIVATE NADPH OXIDASES%REACTOME DATABASE ID RELEASE 66%10146047 RHO GTPases Activate NADPH Oxidases Noxo1 Noxa1 Pik3c3 Ncf1 Rac2 Ncf4 Pik3r4 Nox3 Cybb Nox1 Rac1 Cyba DOWNREGULATION OF ERBB2:ERBB3 SIGNALING%REACTOME%R-RNO-1358803.1 Downregulation of ERBB2:ERBB3 signaling Akt3 Rnf41 Nrg1 LOC102552659 Erbb3 Erbb2 Akt1 Usp8 Akt2 Nrg2 CELL-CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 66%10145495 Cell-cell junction organization Pvrl3 Crb3 Pvrl4 PVR Pvrl1 Pard6a Cdh10 Cdh11 Cdh17 Cdh13 Cdh7 Cdh9 F11r Inadl Jup Cdh24 Pard6b Prkci Cadm3 Cadm2 Pard3 Mpp5 Ang2 Cdh1 Cdh2 Ctnna1 Pvrl2 Sdk2 Cdh3 Ctnnd1 Cdh5 Pard6g Cdh6 Cdh15 SYNTHESIS OF IPS IN THE NUCLEUS%REACTOME%R-RNO-1855191.1 Synthesis of IPs in the nucleus Ipmk Ip6k2 Ip6k1 Ippk SYNTHESIS OF DNA%REACTOME DATABASE ID RELEASE 66%10144719 Synthesis of DNA Rfc1 Psmc6 Rfc2 Psmb10 Psmb8 Pole2 Psmb9 Pole4 Psmb4 Psmb11 Psmb5 Psmf1 Psmb6 Psmd4 Psmb2 Rbx1 Psmd5 Psmd8 Psmd9 Psmb3 Psma8 Psmd11 Psmd12 Prim2 Ccna2 Ccne2 Pola2 Ccna1 Psmd13 Prim1 Ccne1 Psmd14 Mcm2 Mcm4 Mcm3 Cdk2 Mcm5 Rpa3 Mcm6 Pole Pcna Psmc3 Mcm8 Mcm7 Orc4 Orc5 Orc6 Orc1 Orc2 Orc3 Rfc5 Rfc4 Rfc3 Cdc6 Ube2d1 Rpa1 Rpa2 Skp1 Lig1 Anapc7 Cdc26 Cdc27 Cdc23 Ube2c Skp2 Anapc16 Cdc16 Anapc4 Anapc2 Anapc1 Slc25a16 Fen1 Cul1 Anapc11 Anapc15 Anapc10 Fzr1 G6pc Psmb7 Psmb1 Gins3 Gins4 Gins1 Gins2 Psma5 LOC100911727 Cdt1 Pold2 Psma2 Pold1 Pold4 Psmc5 Psma1 Psmd2 Psma4 Psmc1 Psma3 Psmc4 Psma6 Psmc2 Psme1 Psmd1 Psme2 Psmd7 Psmd3 Psmd6 SYNTHESIS OF BILE ACIDS AND BILE SALTS%REACTOME DATABASE ID RELEASE 66%10145312 Synthesis of bile acids and bile salts Nr1h4 Osbp Amacr Akr1d1 Cyp39a1 Ptgis Rxra Acot8 Osbpl3 Hsd17b4 Osbpl6 Osbpl9 Osbpl7 Slc27a5 Abcb11 Cyp7b1 Hsd3b7 Acox2 Akr1c2 Ncoa2 Ch25h Akr1c12l1 Akr1c3 Cyp7a1 Slc27a2 Baat Cyp46a1 Cyp8b1 Akr1c19 Akr1c13 Akr1c14 RGD1564865 Akr1c12 Ncoa1 Akr1c1 APOPTOTIC FACTOR-MEDIATED RESPONSE%REACTOME%R-RNO-111471.1 Apoptotic factor-mediated response Diablo LOC100360940 Xiap GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT%REACTOME%R-RNO-72706.1 GTP hydrolysis and joining of the 60S ribosomal subunit LOC100912571 Eif3l Eif2s3 Eif3m Eif3j Eif3k Rps20 Rps27l Eif3e Eif3f Eif3b Eif3a Eif3d Eif3c LOC100360573 Eif2s1 Eif2s2 Eif4g1 Rps4x LOC100359951 LOC100359593 Eif5 LOC100359503 LOC100362640 Rps3 Rps15a Rps2 Rps13 Rps12 LOC100911372 LOC100361854 LOC684988 LOC103689992 Rps5 Rps7 Rps6 Eif3g Eif3h Eif4a2 LOC100362830 Eif1ax Eif4a1 LOC100363012 LOC680559 LOC100911110 LOC100362149 Rps16 LOC100911431 Rps18 LOC100360679 Rps15 Eif4h Eif4b Rps3a INTRA-GOLGI AND RETROGRADE GOLGI-TO-ER TRAFFIC%REACTOME DATABASE ID RELEASE 66%10146192 Intra-Golgi and retrograde Golgi-to-ER traffic Kif21a Kif21b Kifc1 Kif3c Stx5 Pla2g6 Racgap1 Klc1 Kif22 Arf5 Dync1li2 Kif3b Copa Kif23 Kif18b Kifap3 Igf2r Kif11 Kif12 Kif4a Kif6 Kif1a Arf4 Dync1i2 Kif1c Man1c1 Gbf1 Kif27 Klc4 Kif9 Man1a1 Kif13b Cenpe Klc2 Klc3 Cog4 Cog6 Gcc1 Cog8 Cog3 Man2a1 Pafah1b1 Rhobtb3 Alpp Alpi Cog1 Man2a2 Cog2 Usp6nl Scoc Cog7 Kif3a LOC102555167 Dynll2 Stx6 Rab39a Copz2 Dync1i1 Copz1 Ykt6 Rabepk Vps45 Tmed7 Vps53 Tmed3 Vps52 Tmed2 Cux1 Arfip2 Vps54 Rab6b Rab9a Napg Ric1 Napb Copb1 Napa Rab3gap2 Tmed9 Bicd2 Bicd1 Nsf Alppl2 Golim4 Arl1 Agpat3 Kdelr1 Capza2 Arfrp1 Capza3 Rab6a Arcn1 Kif20b Kif16b Kif26a Kif20a Kif26b Kif19 Rab33b Kdelr2 Plin3 Galnt1 Rab9b Pafah1b3 Galnt2 Kdelr3 Bnip1 LOC100909548 Rab36 Tgoln2 Use1 Rab18 Rgp1 Pla2g4a Actr10 Stx16 Rab43 Stx18 Golga5 Dync1h1 Golga1 Golga4 Dync1li1 Copg1 Dctn5 Dctn6 Rab30 Cyth1 Cyth4 Cyth3 Rab1b Cyth2 Rab1a Trip11 Dctn4 Nbas Arfgap2 Dctn1 Dctn2 Arfgap3 Kif2a Arfgap1 Dctn3 Kif2c Kif2b Kif18a Capzb Kif5b Kif5a Sec22b Cope Snap29 Man1a2 M6pr Vamp4 Vamp3 Gosr2 Actr1a LOC100363782 Gosr1 Zw10 Tmed10 SIGNALING BY RECEPTOR TYROSINE KINASES%REACTOME DATABASE ID RELEASE 66%10144877 Signaling by Receptor Tyrosine Kinases Ptpn18 Ereg Rnf41 Nrg1 Btc LOC102552659 Erbb3 Cilp Erbb2 Abi1 Nrg3 Matk Egfr Abi2 Hbegf RGD1565904 Nrg4 Nos3 Polr2g Nck1 Polr2h Polr2e Polr2f Polr2j Rock2 Polr2k Polr2d Polr2i Polr2b Polr2c Polr2a Mknk1 Atp6v1g1 Atp6v1g2 Atp6v0a4 Esrp2 LOC100912534 Atp6v1b2 Esrp1 Rbfox2 Atp6v0a2 Fyn Atp6v1h Fgfrl1 Atp6v1f Tia1 Ncf1 Tial1 Stat6 Ncf4 Fgfbp3 Fgfbp1 Spry2 Pdgfc Pdgfd Yap1 Thbs4 Plat Ptk2 Cyfip2 Ptpn12 Nckap1 Usp8 Nck2 Nrg2 Sh2d2a Hspb1 Flt4 LOC100911280 LOC100909609 Flt1 Ptk2b Pxn Figf Shc2 Vegfc Nrp1 Dock7 Nrp2 Ranbp9 Vegfb Akt1 Axl Pgf Atp6v0d1 Atp6v1c2 Ntrk1 Atp6v0d2 Ngf Ntf4 Pdgfa Ntrk2 Pdgfb Bdnf Atp6v1a LOC100911822 Atp6v0e2 Atp6v0e1 Atp6v1g3 Cma1 Atp6v1e1 Prkcz Atp6v1e2 Atp6v1c1 Stub1 Kdr Crk Bcar1 Itga3 Vegfa Lama4 Plg Prkca Dock1 Lyn Ntrk3 Ctnnd1 Crkl Ntf3 Cdh5 Yes1 Elmo2 Rasa1 Lama1 Rapgef1 Galnt3 Shb LOC100911248 Dusp3 Dusp4 Mmp9 Frs3 Ptk6 Vrk3 Rps6ka2 Wwp1 Rps6ka1 Rps6ka3 Rps6ka5 Lamc1 Lamc2 LOC100912585 Dusp7 Dusp6 Atf1 Cyfip1 Col9a1 Col9a2 Brk1 Col9a3 Ptpn3 Col4a1 Arf6 Baiap2 Spint1 Gga3 Hgf Thbs1 Ptpn2 Stam2 Fes Pak2 Sh3gl2 Col4a2 Pak3 Sh3gl1 Pak1 Spint2 Sh3kbp1 Ptprk Muc20 Lamb1 Spry1 Nckap1l Hgfac Sh3gl3 Ranbp10 Tns4 Lamb2 Lrig1 Lamb3 Stam Rab4a Spp1 Wasf1 Arhgef7 Rock1 Pdgfra Pdgfrb Vav2 Atp6ap1 Vav1 Flrt1 Flrt2 Shc3 Atp6v0a1 Ctnna1 Mapk13 Mapk12 Csk Pik3c3 Dscam Vav3 Rap1a Pik3r4 Pdpk1 Cdc42 Spred1 Spred2 Ptpn6 Kit Kitlg Atp6v1d Aph1b Psenen Aph1a Ptpn1 LOC100911293 Psen2 Psen1 Rac1 Ncstn Furin Rictor Ap2a2 Fgf2 Dnal4 Diaph1 Ralgds Kidins220 Atp6v0c Src Pik3r3 Cltc Hnrnph1 Clta Ppp2cb Ppp2ca Ppp2r1a Prkcb Ap2s1 Rab4b Ap2a1 Ap2m1 Ncbp2 Mtor Ncbp1 Mapk7 Ppp2r1b Mlst8 Mapkapk3 Mapkapk2 Mapk1 Prkaca Akt3 Prkacb Creb1 Hnrnpm Sh2b2 Hnrnpf Mapk14 Mapk11 Stat5a Ptpru Eps15l1 Stat1 Stat3 Fgf23 Fgf22 Memo1 Fgf4 Grap Fgf1 Fer Fgf3 Tlr9 Fgf6 Fgf5 Fgf20 Gab1 Pde3b Gtf2f1 Igf2 Gtf2f2 Igf1 Fgf16 Fgf17 Irs2 Fgf10 Fgf9 Fgfr2 Fgf7 LOC103692716 Thbs2 Fgf8 Cbl Fgfr3 Cybb Trib3 Cyba Fgfr1 Fgfr4 Grb10 Esr1 Insr Ins1 Ins2 Fgf19 Erbb4 Them4 Irs1 Frs2 Akt2 Prkcd Kras Grb7 Pik3r1 Pik3r2 Tcirg1 Ptprj Jup Mapkap1 Pik3cb Ptpn11 Tec Rhoa Plcg1 Pcsk6 Hras Nras Sos1 Pcsk5 Shc1 Grb2 TRANS-GOLGI NETWORK VESICLE BUDDING%REACTOME DATABASE ID RELEASE 66%10145468 trans-Golgi Network Vesicle Budding Ftl1 LOC100909548 Igf2r Necap1 Clvs1 Picalm Chmp2a Tgoln2 Hip1r Tfrc App Vamp2 Dnm2 Ap1m2 Gbf1 Snx5 Snx9 Snx2 Acbd3 Sort1 Cpd Dnase2 Clint1 Yipf6 Ap4s1 Ap1b1 Vamp8 Tpd52 Sh3gl2 Stx4 Ocrl Ap4e1 Golgb1 Ap4b1 Ap1g2 RGD1561661 Ctsz Napa Tpd52l1 Cltc Cltb Snapin Ap1m1 Clta Ap3b1 LOC100360087 Bloc1s3 Pum1 Txndc5 Ap4m1 Bloc1s4 Bloc1s1 Bloc1s6 Rab5c Arrb1 M6pr Ap1s3 Ap1s1 Ap1s2 Pik3c2a Gak Vamp7 LIGAND-INDEPENDENT CASPASE ACTIVATION VIA DCC%REACTOME DATABASE ID RELEASE 66%10145489 Ligand-independent caspase activation via DCC Appl1 Casp3 Dcc Casp9 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145699 Ionotropic activity of kainate receptors Grik1 Dlg1 Grik3 Grik2 Ncald Grik5 Dlg3 Dlg4 SMAC-MEDIATED DISSOCIATION OF IAP:CASPASE COMPLEXES%REACTOME%R-RNO-111464.1 SMAC-mediated dissociation of IAP:caspase complexes Diablo LOC100360940 Xiap MITOTIC G1-G1 S PHASES%REACTOME DATABASE ID RELEASE 66%10144725 Mitotic G1-G1 S phases Psmc6 Psmb10 Psmb8 Pole2 Psmb9 Pole4 Psmb4 Psmb5 Psmf1 Psmb6 Psmd4 Mnat1 Psmb2 Psmd5 Psmd8 Psmd9 Psmb3 Psmd11 Psmd12 Prim2 Ccna2 Ccne2 Pola2 Ccna1 Psmd13 Prim1 Ccne1 Psmd14 Mcm2 Mcm4 Mcm3 LOC100909750 Cdk2 Mcm5 Rpa3 Mcm6 Pole Mcm10 Psmc3 Ccnh Mcm8 Mcm7 Orc4 Orc5 Orc6 Orc1 Orc2 Orc3 Cdc7 Cdc6 Cdc45 Src Rbl1 Cdk4 Akt1 E2f4 Hdac1 Rpa1 Ppp2cb Ccnd1 Ppp2ca Rpa2 Skp1 Ppp2r1a Tfdp1 Tfdp2 Skp2 Cdkn1a Cdkn1b Ppp2r1b Akt3 Lyn Ppp2r3b Cul1 Ptk6 Rbl2 Cks1l E2f5 Hdac1l Cables1 Dyrk1a Cdkn2b Cdkn2c Cdk6 Cks1b Abl1 Akt2 Gmnn Ccnd3 G6pc Rb1 E2f2 Psmb7 Psmb1 Lin37 Lin52 Lin54 E2f1 Psma5 E2f3 Cdk7 Cdt1 Lin9 Psma2 Psmc5 Psma1 Psmd2 Psma4 Psmc1 Cdc25a Psma3 Wee1 Psmc4 Psma6 Psmc2 Ppp2r2a Psme1 Psmd1 Psme2 Psmd7 Psmd3 Psmd6 HEME DEGRADATION%REACTOME%R-RNO-189483.1 Heme degradation Hmox1 Ugt1a8 Ugt1a9 Ugt1a6 Blvrb Blvra Ugt1a7c Ugt1a5 Ugt1a3 Ugt1a2 Hmox2 Ugt1a1 BIOSYNTHESIS OF DPAN-3-DERIVED MARESINS%REACTOME%R-RNO-9026290.1 Biosynthesis of DPAn-3-derived maresins Alox12 Alox5 TP53 REGULATES TRANSCRIPTION OF ADDITIONAL CELL CYCLE GENES WHOSE EXACT ROLE IN THE P53 PATHWAY REMAIN UNCERTAIN%REACTOME%R-RNO-6804115.1 TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain Btg2 Cdc25c Cnot6l Cnot11 Tnks1bp1 Cnot8 Rqcd1 Cnot3 Cenpj Cnot1 Cnot2 Plk2 Cnot7 Plk3 Cnot4 FGFR3 LIGAND BINDING AND ACTIVATION%REACTOME%R-RNO-190239.1 FGFR3 ligand binding and activation Fgf23 Fgf4 Fgf1 Fgf16 Fgf17 Fgf5 Fgf9 Fgf2 Fgf8 Fgfr3 Fgf20 Galnt3 MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 66%10145043 Muscle contraction Stim1 Tnni1 Dmpk Sri Tnnt3 Tnni2 Tnnt2 Tnni3 Tnnt1 Tmod2 Kcnd3 LOC100911951 Kcnd1 Kcnip3 Kcnip4 Kcnip2 Akap9 Tnnc2 Actn3 Kcnk16 Slc8a3 Mybpc3 Des Tmod4 Tmod3 Vim Tmod1 Ahcyl1 Tpm4 Tpm2 Myl3 Myl4 Mybpc2 Tpm3 Tnnc1 Myl12a Slc8a2 Myh6 Slc8a1 Dmd Myl1 Pxn Cacna1c Cacng7 Cacna1d Cacng1 Kcne1 Kcne2 Kcnk5 Cacng5 Kcnk6 Kcnk7 Kcne4 Scn2a Scn7a Scn4b Scn2b Fgf11 Scn9a Fgf12 Fgf13 Scn10a Scn4a Nos1 Tln1 Scn5a Fgf14 Scn3a Scn11a Rangrf Scn1b Prkaca Kcne3 Cacnb4 Cacng8 Cacnb1 Itpr1 Cacnb2 Kcnq1 Cacna2d3 Itpr3 Cacna1f Kcne5 Cacng2 Cacna1s Cacng3 Cacna2d2 Cacng4 Cacna2d4 Camk2g Atp2b4 Myh11 Vcl Kcnh2 Atp2b2 Atp2b1 Camk2d Actn2 Camk2a Clic2 Trdn Atp2a2 Pln Atp2a3 Kcnj2 Kcnj11 Kcnj14 Pak2 Pak1 Kcnk1 Kcnk12 Kcnk13 Kcnk2 Kcnk3 Npr2 LOC100909725 Npr1 Kcnk4 Kcnj12 Kcnk10 Nppc Nppa Kcnk9 Kcnk15 Corin Abcc9 Fxyd2 Kcnj4 Fxyd3 Fxyd4 LOC102551071 Sln Mylk Fxyd6 Fxyd7 Dysf Atp1b3 Myl10 Atp1b2 Atp1b1 Cav3 Fkbp1b Myl7 Actg2 Sorbs3 Cald1 Ryr2 Trim72 Sorbs1 Mylpf Kcnk18 Atp1a4 Atp1a1 Atp1a2 Atp1a3 DEATH RECEPTOR SIGNALLING%REACTOME DATABASE ID RELEASE 66%10144808 Death Receptor Signalling Faslg Nsmaf Cflar Fadd Adam17 Aph1b Psenen Aph1a Ngfr LOC100911293 Psen2 Psen1 Ncstn Rac1 Casp3 Tnf Tradd Tnfsf10 Fas Rnf31 Sharpin Traf1 Rbck1 Sqstm1 Prkci Ngf Tax1bp1 Sppl2a Clip3 Otulin Xiap Ywhae Bad Nfkb1 Bag4 Mapk8 Smpd2 Smpd3 Chuk Traf2 Usp4 Tab2 Tab3 Ikbkb Myd88 Ripk2 Usp21 Otud7b Madd Traf6 Tab1 Ripk1 Rela Map3k7 Tnfaip3 Nfkbia LOC100910771 Itgb3bp Arhgef6 Arhgef5 Arhgef39 Arhgef7 Arhgef37 Birc3 Arhgef38 Birc2 Arhgef33 Cyld Prex1 Itsn1 Arhgef2 LOC102556447 Arhgef4 Arhgef3 Plekhg5 Arhgef19 Arhgef18 Plekhg2 Kalrn Bcl2l11 LOC100912512 Vav2 Gna13 Casp2 Vav1 Arhgef11 Akap13 Casp8 Arhgef16 Arhgef15 Net1 Ect2 Arhgef26 Usp2 Fgd2 Mcf2l Tiam1 Tiam2 Vav3 Fgd3 Sos2 Ngef Rhoa Arhgdia Rtn4 Lingo1 Omg Sos1 Mag Ngfrap1 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR)%REACTOME DATABASE ID RELEASE 66%10145798 Downstream signaling events of B Cell Receptor (BCR) Psmc6 Psmb10 Psmb8 Psmb9 Psmb4 Psmb11 Nfkbib Psmb5 Psmf1 Psmb6 Psmd4 Psmb2 Cul1 Psmd5 Psmd8 Psmd9 Psmb3 Psma8 Psmd11 Psmd12 Psmd13 Rela Psmd14 Psmc3 Nfkbia Kras G6pc Psmb7 Psmb1 Skp1 Prkcb Ppp3r1 Nfkbie Nfkb1 Psma5 Fbxw11 Rasgrp1 Chuk Rasgrp3 Btrc Psma2 RGD1560225 Psmc5 Ppp3ca Psmd2 Psma1 Nfatc2 Psma4 Psmc1 Psma3 Psmc4 Psmc2 Psma6 Psme1 Hras Psmd1 Psme2 Nras Psmd7 Ikbkb Nfatc3 Psmd3 Psmd6 TNFR1-INDUCED PROAPOPTOTIC SIGNALING%REACTOME DATABASE ID RELEASE 66%10144945 TNFR1-induced proapoptotic signaling Traf2 Usp2 Fadd Usp21 Usp4 Otud7b Cyld Ripk1 Tnf Tradd Tnfaip3 KSRP (KHSRP) BINDS AND DESTABILIZES MRNA%REACTOME DATABASE ID RELEASE 66%10145696 KSRP (KHSRP) binds and destabilizes mRNA Exosc9 Exosc2 Exosc1 Exosc4 Exosc7 Exosc5 Dcp2 Ywhaz Exosc3 Khsrp Akt1 BIOSYNTHESIS OF PROTECTINS%REACTOME%R-RNO-9018681.1 Biosynthesis of protectins Cyp1a1 Cyp1a2 Alox15 Lta4h SIGNALING BY ERYTHROPOIETIN%REACTOME DATABASE ID RELEASE 66%10146295 Signaling by Erythropoietin Gab1 Pik3r5 Irs2 Pik3r1 Pik3cb Lyn Epor Crkl Pik3cd Vav1 Pik3cg Rapgef1 Shc1 Epo LOC100911248 Grb2 DISINHIBITION OF SNARE FORMATION%REACTOME DATABASE ID RELEASE 66%10145035 Disinhibition of SNARE formation Stxbp3 Stx4 Prkca Prkcb CATECHOLAMINE BIOSYNTHESIS%REACTOME%R-RNO-209905.1 Catecholamine biosynthesis Pnmt Ddc Dbh Th TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES%REACTOME%R-RNO-425393.1 Transport of inorganic cations anions and amino acids oligopeptides Slc7a3 Slc7a2 Slc7a1 Slc6a12 Slc4a7 Slc4a9 Slc7a8 Slc7a9 Sri Slc7a5 Slc7a6 Slc7a7 Slc7a10 Slc4a4 Slc4a3 Slc4a8 Slc6a6 Slc12a4 Slc12a2 Slc12a1 Slc8b1 Slc38a3 Slc38a2 Slc38a5 Slc38a4 Slc8a3 Slc12a5 Slc3a1 Slc25a29 Slc43a2 Slc43a1 Slc12a6 Slc12a7 Slc25a10 Slc8a2 Slc8a1 Slc16a10 Slc1a3 Slc9a4 Slc1a5 Slc9a5 Slc1a4 Slc15a1 Slc1a7 Slc26a7 Slc1a6 Slc26a9 Slc26a6 Slc1a1 Slc26a3 Slc36a2 Slc9a1 Slc34a1 Slc34a3 Slc32a1 Slc38a1 Slc6a15 Slc6a14 Slc6a19 Slc6a18 Ctns Slc36a4 Slc6a20 Slc36a1 Slc24a4 Slc24a2 Slc20a2 Ahcyl2 Slc5a8 Slc25a22 Slc17a5 Slc17a6 Slc4a2 Slc17a7 Slc4a5 Slc17a8 Slc4a1 LOC100911440 Slc25a18 Slc7a11 Slc5a5 Slc24a5 Slc26a2 Slc26a1 Slc9a2 Slc9a9 Slc9a3 Slc9a6 Slc20a1 Slc4a10 Slc9a8 Slc15a3 Slc9a7 SIGNAL ATTENUATION%REACTOME%R-RNO-74749.1 Signal attenuation Grb10 Insr Ins1 Irs2 Ins2 Irs1 Sos1 Shc1 Mapk1 Grb2 NONHOMOLOGOUS END-JOINING (NHEJ)%REACTOME%R-RNO-5693571.1 Nonhomologous End-Joining (NHEJ) Bard1 Bre Rad50 Brcc3 Xrcc6 Xrcc5 Pias4 Uimc1 Atm Hist1h2bo Hist1h2bcl1 Hist1h2bk Sumo1 Brca1 Mdc1 Ube2v2 Ube2n Nbn Mre11a LOC100910200 Whsc1 H2afx Hist1h4b Rnf8 Hist1h2bh LOC100912290 Babam1 Tp53bp1 LOC686349 Hist1h4m LOC100912338 Herc2 Xrcc4 Hist2h4 Hist1h2bq LOC100364835 Fam175a Tdp2 Lig4 Paxip1 Polm Hist1h2bg Nhej1 Prkdc LOC680097 Dclre1c Poll LOC684797 LOC100912418 Hist1h2ba Hist3h2bb BASIGIN INTERACTIONS%REACTOME%R-RNO-210991.1 Basigin interactions Atp1b3 Atp1b2 Atp1b1 Bsg Slc7a8 Slc7a9 Itga3 Mmp1 Slc7a5 Slc7a6 Slc7a11 Slc7a7 L1cam LOC288521 Ppil2 Slc7a10 Spn LOC100361537 Itga6 Slc16a3 Slc16a8 Mag Slc16a1 SUMO IS CONJUGATED TO E1 (UBA2:SAE1)%REACTOME DATABASE ID RELEASE 66%10145983 SUMO is conjugated to E1 (UBA2:SAE1) Sumo1 Sae1 Uba2 NUCLEAR SIGNALING BY ERBB4%REACTOME%R-RNO-1251985.1 Nuclear signaling by ERBB4 Stat5a Esr1 Src Yap1 Aph1b Psenen Aph1a Erbb4 LOC100911293 Psen2 Psen1 Ncstn LIPOPROTEIN METABOLISM%REACTOME DATABASE ID RELEASE 66%10145205 Lipoprotein metabolism Ldlr Angptl4 LOC100361444 Lmf1 Lmf2 Furin Ap2a2 Abca1 Zdhhc8 Lcat Lipg Pltp Bmp1 Sar1b Apob Apoc2 Apoe Apoa2 Mttp Nr1h3 Nr1h2 Gpihbp1 Cltc Scarb1 Cubn Clta Amn Hdlbp Apoa1 Ap2s1 Ap2a1 Ap2m1 Pcsk9 P4hb A2m Apobr Vldlr Npc1 Nceh1 Lipa Mylip Soat1 Soat2 Prkaca Prkacb Lpl Apoc1 LOC100910181 Abcg1 Pcsk6 Apoc4 Ldlrap1 Pcsk5 CA ACTIVATED K+ CHANNELS%REACTOME DATABASE ID RELEASE 66%10145832 Ca activated K+ channels Kcnn4 Kcnn1 Kcnma1 Kcnmb4 Kcnmb3 Kcnn2 Kcnn3 Kcnmb2 Kcnmb1 SYNTHESIS OF IPS IN THE ER LUMEN%REACTOME%R-RNO-1855231.1 Synthesis of IPs in the ER lumen Minpp1 LEUKOTRIENE RECEPTORS%REACTOME%R-RNO-391906.1 Leukotriene receptors Gpr17 Ltb4r Cysltr2 Cysltr1 Ltb4r2 CELL JUNCTION ORGANIZATION%REACTOME%R-RNO-446728.1 Cell junction organization Pvrl3 Crb3 PVR Pvrl4 Pvrl1 Rsu1 Cdh10 Cdh11 Cdh17 LOC100911730 Cdh13 Cdh7 Cdh9 Fermt2 Flnc Inadl Cdh24 Pard6b Cd151 Lamc2 Itgb4 Cadm3 Itga6 Cadm2 Mpp5 Ang2 Flna Pvrl2 Plec Cdh15 Actn1 Lamb3 Parvb Lims1 Arhgef6 Ilk Pard6a Dst F11r Jup Prkci Fblim1 Vasp Pard3 Cdh1 Cdh2 Ctnna1 Sdk2 Ctnnd1 Cdh3 Pard6g Cdh5 Cdh6 Col17a1 PHOSPHORYLATION OF THE APC C%REACTOME DATABASE ID RELEASE 66%10145220 Phosphorylation of the APC C Anapc7 Cdc26 Cdc27 Cdc23 Ube2c Ube2d1 Cdk1 Anapc16 Cdc16 Anapc4 Anapc2 Anapc1 Anapc11 Anapc15 Anapc10 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY%REACTOME DATABASE ID RELEASE 66%10145655 Zinc influx into cells by the SLC39 gene family Slc39a2 Slc39a3 Slc39a4 Slc39a14 Slc39a6 Slc39a7 Slc39a8 P75 NTR RECEPTOR-MEDIATED SIGNALLING%REACTOME%R-RNO-193704.1 p75 NTR receptor-mediated signalling Ripk2 Adam17 Aph1b Psenen Aph1a Ngfr LOC100911293 Psen2 Psen1 Rac1 Traf6 Ncstn Casp3 Rela Sqstm1 Nfkbia Itgb3bp Arhgef6 Arhgef5 Arhgef39 Arhgef7 Arhgef37 Arhgef38 Arhgef33 Prex1 Itsn1 Arhgef2 LOC102556447 Arhgef4 Arhgef3 Plekhg5 Prkci Arhgef19 Arhgef18 Plekhg2 Ngf Kalrn Bcl2l11 LOC100912512 Vav2 Gna13 Casp2 Vav1 Arhgef11 Akap13 Ywhae Arhgef16 Arhgef15 Bad Net1 Nfkb1 Ect2 Arhgef26 Mapk8 Fgd2 Mcf2l Tiam1 Tiam2 Vav3 Fgd3 Sos2 Ngef Rhoa Arhgdia Rtn4 Lingo1 Omg Ikbkb Mag Sos1 Myd88 Ngfrap1 METABOLISM%REACTOME DATABASE ID RELEASE 66%10144767 Metabolism Smarcd3 Enoph1 Mtap Mri1 Adi1 Abcd1 Acot6 Acot4 Acot8 Acox1 Ehhadh Eci3 Hsd17b4 Mlycd Ecsit Mapkapk2 Fabp2 Gpam Mogat1 Fabp9 Lpin2 Mogat2 Lpin3 Lpin1 RGD1562200 Dgat2 Gk2 Plin3 Gpat2 Gpd2 Agmo Gpihbp1 Arsi Smpd1 Arse Cptp Arsg Smpd2 Esyt3 Smpd3 Arsk Sts Esyt2 Smpd4 Gba2 Sumf2 Sumf1 B3galnt1 Ugt8 Ugcg Med1 Fabp3 Fabp6 Fabp1 Fabp4 Gk Fabp12 Pnpla5 Fabp7 Mgll Carm1 Ptges3 Ptges3l1 Crebbp Folr2 Ncoa1 Pik3r1 Pik3r2 Adra2a Gnai2 Adra2c Pik3cb Gnai1 Oca2 Slc45a2 Tyrp1 Tyr LOC308670 Bsg Fah Tat Pnlip LOC103690254 Try10 LOC100365995 Pcbd1 Aanat Hpd Asmt Phykpl Tph1 Slc2a2 Tph2 Hgd Clps Il4i1 Pah Asrgl1 Qdpr Ipmk Ip6k2 Blvrb Blvra Minpp1 Prkca Pnmt Ddc Dbh Th Try4 Prss2 Prss1 Rimklb Gpt Aspa Nat8l Naalad2 Folh1 Pycrl Aldh18a1 Oat Asns Pycr2 Pycr1 Prkg2 LOC102554637 Ndufab1 Ppapdc2 Pten Ptgds Pla2g6 Pla2g3 LOC683884 Pla2g5 Pitpnb Helz2 Sc5d Pla2g16 Dpep3 Pla2g15 Dpep1 Pla2g10 LOC103689982 Lhb Nsdhl Osbpl5 Osbpl8 Osbpl3 Osbpl6 Osbpl9 Fam73b Osbpl7 Cyp19a1 Fdx1l Ppap2a Por LOC100360055 Sacm1l Aoc3 Ppap2b LOC683849 Slc22a5 Ces2c Awat1 Awat2 Msmo1 Agps Cpt1b Alpp Alpi Cpt1a Acat2 Acat1 Fig4 Ttr LOC100911154 Cpne6 Acp6 LOC100910957 Cpne7 Mcat Cers4 LOC100910122 Cers3 Mvd Agk Acot11 Slc25a17 Cers6 Cyp4f17 Tmem86b Lclat1 Acot13 RGD1564865 Slc25a20 Cga Cyp4f18 Pik3r5 Bmx Aacs Etnppl Tbxas1 Cept1 Pik3r3 Pik3r6 Cers1 Acer2 Acer1 Acer3 Pi4kb Cyp51 Mut Cers2 Inpp5d Inpp5e Ppt1 Ppt2 Ncoa6 Gdf1 Slc21a4 Inpp5f Bzrap1 Tnfaip8l3 Dgat2l6 Tnfaip8l1 Abcb11 Inpp5j Tnfaip8 Tnfaip8l2 Stard3nl Vapb Rufy1 Ormdl1 Acox3 Ptdss2 Acox2 Srd5a3 Cdipt Aldh3a2 Sin3a Sin3b Cyp4f6 Ormdl2 LOC317456 Ppap2c Osbpl10 Cbr1 Tspo Crls1 LOC100912391 Cpt2 Cyp24a1 Mcee Srd5a1 Srd5a2 Pmvk Srebf1 Pik3c2a Pik3c2b Srebf2 Pik3c2g Cds2 Hmgcll1 Cyp4a2 Adprm Pla2r1 Nudt9 Sqle Nudt5 Cyp4a1 Nudt16 Ptgis Nudt18 Tpte2 LOC688828 Pla2g4e Pla2g4b Lgmn Pla2g4d Inpp4a Pdss2 Aloxe3 Cyp4a8 Coq2 Inpp4b LOC100912469 Pctp Pla2g4a Cds1 Cbr4 Acot7 Acot9 Pla2g4c Acot2 Cyp2j10 Acot5 Fdft1 Acss3 Kcnj11 Abcc8 Nudt15 Nudt1 Cyp2b2 Cyp2c24 Cyp2s1 Cyp2b1 Marc2 Marc1 Aip Cyp2b3 Ephx1 Nqo2 Cyp26c1 Aldh3a1 LOC100910040 Bphl Ahrr LOC100361492 Ahr Maob LOC100910127 Ces1d Cyp2c13 LOC100910481 Aadac Cmbl Ces2 Slc5a8 Ces2j Cyp2b21 Arnt Ces2e Ces2g Acss1 Cbr3 Ces2h LOC100911763 Slc5a5 Cyp2b15 Fmo1 Cyp2b12 Adh4 Fmo2 Cyp2f4 Cyp26a1 Adh6 Arnt2 Adh7 Cyb5b Cyp4v3 Aldh1b1 Cyp26b1 LOC100365112 Nr1h4 Bpnt1 Abhd14b Enpp6 Nat1 Cyp1b1 Nat2 Mbtps1 Cidec Sult6b1 Tecr Podxl2 Sult4a1 Mbtps2 Sgpl1 Sult2a1 Echs1 Nudt7 Sbf1 Ptpn13 Nat3 Hdac3 Slc7a5 LOC100365676 Hsd17b3 Hsd17b8 Csnk2a2 Acsbg1 Hsd17b1 Hsd17b2 Pla2g12a Far2 Far1 Csnk2a1 Stard7 Slc6a7 Stard6 Slc46a1 Acoxl Stard3 Fa2h RGD1562948 Gc Acsbg2 Alox5ap Sptssb Lpcat4 Sptssa Eci1 Stard4 Stard5 Plbd1 Abhd4 Akr1c12l1 Lipi Mid1ip1 Baat Cyp46a1 Lpcat3 Slc22a3 Lpcat2 Fitm1 Acy3 Fitm2 LOC100910526 Hpgds RGD1562392 Akr7a2 Gnpat Akr1c19 ste2 Impad1 Vac14 Tpst1 Abhd3 Thrsp Tpst2 Tbl1x Sult2b1 NEWGENE_1306455 Hsd3b Akr1c13 LOC100910057 Akr1c14 Sult1b1 LOC100910881 LOC681458 Sult1a1 Akr1c12 Sult1c2 Pla2g4cl1 Acy1 Fasn Chat Xylb Ncan Csnk1g2 Hexb Amacr Hexa Akr1d1 Chst7 Cyp4f39 Chst9 Cyp39a1 Pomc Ugp2 Pld2 Vdr Pld6 Tecrl Synj1 Scap Fdx1 Sds Plekha4 Plekha3 Hrsp12 Slc9a1 Plekha5 Chst5 Pon3 Sdsl Pon1 LOC102550316 Chst3 Pon2 Nup88 Plekha8 Chst2 Degs2 Chst1 Synj2 B3gnt4 Plekha1 Hsd3b1 B3gnt7 Alppl2 B3gnt1 Hsd3b2 B3gnt2 Pik3cd B3gnt3 Pik3cg Nup85 Hsd3b7 Pgk2 G6pc3 Acadvl Acsl3 Pgk1 Acsl1 Gpc6 Acsl6 Rbks Acsl5 Slc37a2 Acsl4 Pkm Taldo1 Agpat1 Slc35d1 Chpf2 Agpat4 Agpat3 Gpc4 Ch25h Gpc2 RGD1564347 Ndst1 Pnpla8 Pgam1 Agpat9 Pgam2 Acaa2 Ndst2 Cyp2u1 Rae1 Cryl1 Agpat6 Agpat5 Ndst3 Etnk1 Ndst4 Adpgk Pnpla3 Ogn Alox15b Pnpla2 Glb1 Pnpla6 Pck1 St3gal2 Samd8 St3gal3 Acbd7 Acad10 Slc26a2 Acad11 Slc26a1 St3gal1 Ptgs1 Bpgm Acbd5 Gpc1 Hacl1 Nhlrc1 Acbd6 Slc37a1 Dhcr24 Mmaa St3gal4 St3gal6 Acbd4 Pi4k2b B3galt6 Slco1a1 Nup93 Ddhd2 Slc35b2 Epm2a Ddhd1 Arv1 Kera Slc44a4 Nup98 Phyh LOC100911625 Nup107 Slco1a4 Slco1a2 Slc35b3 Eno3 Slc44a5 Mboat1 Glyctk RGD1306195 Gapdhs Manba Slc44a3 Eno1 Hmgcl Slco1b2 Tkfc Mboat7 Eno2 LOC688708 Nup210 Akr1b7 Aldoa Akr1b8 Prelp Kdsr LOC100911750 Mtmr14 Gyg1 LOC102556347 Aldob Ppara Aldoc Mtmr12 Cspg5 Taz Cspg4 Iscu Nupl2 Ppard Star Pgls Isca2 Gckr Acadl Isca1 Hmgcs2 Nupl1 Pklr Acads Acan Cyp7b1 Lyrm4 Pc Acadm Glrx5 Dsel Sgpp2 Tyms Pip5k1c Tkt Bcan Dtymk Hrasls5 Pi4k2a LOC305806 Pfkfb3 Nme3 Pfkfb4 Pip5k1b Nmral1 Nudt13 Pfkfb1 Pip5k1a Hmgcs1 Ass1 Nme1 Pfkfb2 Chsy1 Akr1c2 Ak5 Nags Cps1 Khk Scd4 Ak4 Hao2 Ak6 Slc25a2 Pfkl Akr1c3 Ak8 Pgm2 Prps2 Rrm2b Cyp7a1 Tm7sf2 Pgm1 Dut Cyp21a1 LOC100910284 Ctps2 Fdxr Ctps1 Pfkp Pcyt1b B4galt1 Pcyt1a Ext1 Tgs1 Ext2 LOC100911186 B4galt3 Them5 B4galt2 Acsf2 B4galt6 Cyp2r1 B4galt7 Scd1 B4galt4 Scd2 B4galt5 Acsf3 Hs3st3b1 Glrx Pitpnm1 Nup205 Aldoart2 Dbi Rrm2 Pitpnm3 Naglu Rrm1 Slc25a11 Pitpnm2 Lalba Morc2 Dctd Slc25a10 LOC100360124 Ocrl Akr1c1 Phka1 LOC100359853 LOC100911941 Guk1 Cemip Shpk Stard10 Osbp Agrn Stab2 Fads1 Hk2 Pcyt2 Xylt2 Mtmr9 Mtmr6 Pgm2l1 Mtmr7 G6pc Mtmr2 Agl Serinc4 Chst12 Ggps1 Nup155 Psph Dpep2 Serinc2 Chst11 Ptges Serinc3 Lum Tbl1xr1 Srr Dcn Faah Serinc1 Tpi1 Pla2g2a Pla2g2f Csgalnact1 Pla2g2d Csgalnact2 Hs6st2 Gmpr2 Gpd1l Ampd1 Chst13 Pla2g1b LOC686302 Gmpr Prps1l1 Elovl1 Gys1 Gpi LOC100911615 Elovl5 Gys2 Elovl2 Slc25a1 Rpia Elovl3 Xdh Papss2 Crot Slc27a5 Papss1 Hs6st1 Chka Mtmr3 Idua Dguok Ust Mfsd2a Mtmr1 Hprt1 Chst15 Slc36a4 Elovl6 Chst14 Ada Ampd2 Nup153 Cyp11b2 Rpe Sgms1 Mthfs Cyp27b1 Mthfd1l Vcan Phkg1 Morc2b Mthfd2l Decr1 Gale Dhfr Slco1a6 Hs3st3a1 Omd Hacd1 Dse Phospho1 Tpr Dhcr7 Mthfr Mthfd2 Glb1l Bdh2 Hadh Galk1 Mthfd1 Akr1b1 Shmt1 Sphk2 Aldh1l2 Arsb Lpgat1 Hadha LOC100910891 Aldh1l1 Slc19a1 Phkg2 Col4a3bp Man2c1 Slc25a32 Hadhb Gnpda2 Shmt2 Cyp8b1 Dera Gpd1 Akr1a1 Hsd17b14 Slc35d2 Slc10a1 Hmgcr Nup54 Psat1 Gusb Ebp Pemt Phgdh Hpse Man2b1 Crat Slc2a1 Pccb Pom121 Hacd4 Hs3st5 Hacd3 Chpf Pikfyve Hsd11b2 Nup62 Hs3st2 Hsd17b13 Hs3st1 Slc10a2 Dcxr Hsd17b12 Hs3st6 Hsd17b11 Cd44 Phkb Lyve1 Nup43 Nup133 Mdh2 Gaa Mdh1 Has1 Aaas Pygl Has2 Pygm B3gat1 B3gat3 B3gat2 Npap60 Got1 Fbp1 Nup35 Fbp2 Hyal1 Nup37 Hyal2 Chp1 Sdc2 Sdc3 Sdc4 Sord Fmod Galt Got2 Hs2st1 Ranbp2 Ppp1r3c Car6 Car13 Car12 Car3 Car7 Car9 Car5a Car14 Car5b Cpox Fech LOC687381 Ppox Hmbs Cox10 Alas2 LOC100911779 Cox15 Urod Uros Ckb Sms LOC100912604 Ckmt1b Amd1 Gamt LOC100364487 Srm Amdhd1 Carns1 Hnmt Hal Hdc Ftcd Uroc1 Glul Aox1 Pnpo Bckdk Bcat1 Hsd17b10 Bcat2 Sptlc3 Hibadh Sptlc1 Auh Prkd3 Aldh6a1 Sptlc2 Ivd Prkd1 Acadsb Hibch Prkd2 Tmlhe Ppm1k Oxct1 Ugdh Cad Ppa2 Prodh Nt5c1b Scly Gda Itpa Samhd1 Umps Dnph1 Dhodh Plcb1 Plcb3 Ffar1 Gnaq Gna11 Gna14 Gna15 Plcd3 Plcz1 Plcd1 Plcd4 Inpp5b Itpka Plce1 Pld4 Plch1 Plch2 Plcb4 Maoa Slc22a1 Slc22a2 Aldh2 Itpkb Comt Itpkc Bche Nt5c1a Nt5c Nt5c3a Nt5e Ache Upb1 Nt5m Akt1 Dpys Agmat Ucp2 Ucp3 LOC100909612 Slc25a14 Ucp1 Pdxk Ctsa Pnp LOC100909857 LOC498300 Arg1 Psmb7 Psmb1 Vapa Nme2 Psma5 Rap1a Psma2 Psmd2 Idh1 Bst1 Psmc2 Psmd1 Psmd7 Psmd3 Psmd6 Slc6a11 Slc6a12 Tpo Iyd Duox2 Duox1 Tshb Nudt11 LOC100912928 Nudt3 Ppip5k1 Ppip5k2 Nudt10 Ip6k1 Ippk Nudt4 Itpk1 Rxra Mpst Txn2 Suox Cbs Sqrdl Bhmt2 Ethe1 Cdo1 Cth Tstd1 Tst Sar1a Lrp1 Plcg1 Cacna1e Glyatl3 Acsm1 Slc25a5 Adipor1 Glyat Adipor2 Marcks Adipoq Mmadhc Abcd4 Cd320 Mmab Tcn2 Mmachc Ctrc Lmbrd1 Lpcat1 Acacb Slc5a6 Mccc2 Pdzd11 Hlcs Mccc1 Gcsh LOC100911156 Ndufaf7 Ndufa7 Ndufaf5 Rfk LOC100911034 Pts Apoa1bp Tpk1 Rnls Carkd Slc52a2 Slc52a3 Slc23a2 Gch1 Nampt Mocs1 Ldha Cd38 Ndufb6 Ndufb3 Enpp1 Parp14 LOC100912599 Ndufb5 LOC100910173 Vdac1 Nudt12 Nmnat2 Ldhb Nmnat1 LOC100361505 Acp5 Me2 Hagh Mocos Fahd1 Nmrk1 Nmrk2 Me3 Nfs1 Ndufb9 Nadsyn1 Ndufb4 Ndufb8 Cyb5a Gchfr Ndufb7 Flad1 Sdhc Parp9 Sdhd Mocs3 Ndufaf3 Parp6 Sdha RGD1563242 Me1 Atp5j2 Thtpa Parp8 Dlst Qprt Ndufaf1 Ndufa2 Ndufa5 Ndufaf4 Ndufa6 Slc19a2 Mt-atp8 Sdhb Nadk RGD1306782 Slc25a19 Ndufa1 Ndufs3 LOC500350 Ndufs1 Ogdh Ndufs4 Atp5g3 Ndufs5 Ndufs2 Ndufs8 Coq10a Ndufs6 Ndufs7 Pdpr Timmdc1 Pdhb Atp5g2 Pdk3 Pdk4 Pdk1 Pdk2 LOC100365902 LOC684509 Pdha2 Pdha1 Pdhx Pdha1l1 Acad9 Suclg2 Ndufb2 Ldhc Nnt LOC679739 LOC100911417 Idh3a Etfdh Gstz1 LOC679195 D2hgdh Pdp1 LOC100910710 Aco2 LOC680288 Adhfe1 Idh3B LOC688963 Dlat L2hgdh Atp5l Atp5o Atp5h Tmem126b Atp5i Atp5j LOC100363268 Ndufv3 LOC100361144 Ndufv1 Ndufv2 Atp5s Atp5e Atp5d Fh Atp5b Dld Mt-nd4 Atp5f1 Cda Ndufa7l Mt-nd5 Psap Sardh Etfa Dmgdh Etfb Svs1 Chdh Idh3g Mt-nd6 Entpd2 Nubpl Mt-nd2 Glo1 Idh2 Entpd6 LOC100911483 Entpd3 Cs Entpd4 Ndufb10 Acly Entpd1 Ndufb11 Entpd7 Ndufa12 Ndufa11 Doxl2 Entpd5 Doxl1 Mt-atp6 Entpd8 Cpne3 Ndufa13 Ndufa10 Psmd11 Sucla2 Psmd12 Fabp5 Psmd13 Psmd14 Aldh3b1 Ndufc2 Aprt Cpne1 Psmc3 RGD1564463 Mgst1 Ugt2b Ugt1a8 Ugt2b37 Ugt1a9 Ugt1a6 Ugt2b35 Ugt2a1 Ugt2b15 Hsp90ab1 Ugt1a1 Ugt2b17 RGD1559459 Ptges2 Alox5 Ugt1a7c Ugt1a5 Ugt1a3 Ugt1a2 Neu1 Lta4h Ampd3 Slc27a2 Dgat1 Naprt1 Gm2a Inpp1 Kpnb1 Inpp5a Isyna1 Pld1 Impa1 Impa2 LOC100910990 Vnn1 Kmo Kynu Ccbl1 Ido1 Arsa Tdo2 Lipt2 Lipt1 Agxt2 Acaa1a Bckdhb Acaa1b Amt Grhpr Hao1 Hoga1 Gnmt Tas1r2 Slc44a2 LOC103692716 Ddo Ubiad1 Dhtkd1 LOC100911564 Aldh4a1 Dbt Gldc Agxt Iffo2 Lias Rbm12 Gstp1 Hscb Asah1 Otc Hmox2 Impdh1 Impdh2 Csnk2b Alad Gla Rbp4 Lrp10 Rbp2 Tex12 Rbp1 Lrp8 Aoc1 Ttpa Apom Agpat2 Lrp12 Lpl Bco1 Rdh11 Lrat Cyb5r3 Bco2 Degs1 Nosip Nos3 Dnm2 Ddah2 Zdhhc21 Nostrin Ddah1 Spr Cygb Car2 Car1 Cacna1c Cacna1d Ncor2 Mtmr4 Gsta5 Gss Cacnb2 Cacna2d2 Nt5c2 Adal Gstm7 Ggct Esd Gclm Gstm5 Gsto2 Gstk1 Cndp2 Gclc LOC100912430 Gstt2 Ggt7 Ggt6 Chac2 Chac1 Mgst3 Oplah Pank4 Coasy Pank3 Pank2 Ppcs Apob Apoc2 Pank1 Apoe LOC100362038 Apoa2 Aasdhppt Gng10 Acss2 Ppcdc Uck1 Tymp Dck Txnrd1 Prkab2 Gsr Adcy5 Adcy6 Prkar1b Prkar1a Uckl1 Tk2 Hdhd1 Uck2 Upp1 Upp2 Tk1 Tmem55b Pip4k2b Pip4k2c Neu4 Neu2 Gltp B4galnt1 Neu3 Cerk Enpp7 Gba Galc Asah2 Txn1 Prkaa2 Prkar2b Prkar2a Smox Sat1 RGD1564480 Paox Cyp2d5 Cubn Amn Apoa1 Hpgd LOC100361547 Gpx4 Cyp3a23/3a1 Cyp3a73 Cyp2c7 Pfas Alox12 Ppat Cyp2e1 Ltc4s LOC100912917 Gstm4 Cyp2d4 Cyp3a18 Cyp1a1 LOC100910877 Adss Gmps Cyp2d2 Ptgs2 Lhpp Atic Ephx2 Cyp1a2 Gart Alox15 Adsl Adssl1 Cyp2d3 Paics Cyp2c6v1 Gcgr Pipox Aldh7a1 Gcdh Aadat Wasl Hykk Pik3c3 Ncoa2 Pik3r4 Nqo1 Psmc6 Oaz3 Psmb10 Oaz1 Oaz2 Psmb8 Psmb9 Psmb4 Psmb11 Psmb5 Psmf1 Psmb6 Psmd4 Psmb2 Psmd5 Psmd8 Psmd9 Psmb3 Azin1 Psma8 Slc16a3 Slc16a8 Slc16a1 Mat1a Mat2b LOC100363915 Ahcy N6amt1 Nnmt Mat2a As3mt Tpmt Mtrr Trmt112 Gsto1 Mtr Gnb3 Gnb5 Kcnc2 Gnb2 Gnb1 Gng13 Gng12 Gng11 Prkaca Prkacb Itpr1 Kcns3 Rapgef4 Itpr3 LOC100912034 Gnb4 Glp1r Gcg Gng4 Gngt2 Gng5 Gngt1 Gng8 Gng3 Hmox1 Them4 Psmc5 Psma1 Psma4 Psmc1 Psma3 Psmc4 Psma6 Psme1 Odc1 Psme2 XBP1(S) ACTIVATES CHAPERONE GENES%REACTOME%R-RNO-381038.1 XBP1(S) activates chaperone genes Sec63 Serp1 Sec61a1 Sec62 Sec61a2 Sec61b Asna1 LOC100363239 Sec61g LOC100361694 COPI-MEDIATED ANTEROGRADE TRANSPORT%REACTOME%R-RNO-6807878.1 COPI-mediated anterograde transport Stx5 Bet1 Dync1li2 Arf5 Copa LOC100910557 Sptan1 Dync1i2 Arf4 Gbf1 Actr10 Cog4 Cd59 Dync1h1 Cog6 Cog8 Cog3 Cog1 Cog2 Dync1li1 Cog7 LOC102555167 Copg1 Dynll2 Dctn5 Dctn6 Copz2 Ins1 Dync1i1 Copz1 Ins2 Rab1b Rab1a Ykt6 Dctn4 Tmem115 Folr1 Dctn1 Tmed7 Arfgap2 Tmed3 Ank1 Tmed2 Dctn2 Uso1 Golgb1 Arfgap3 Napg Gorasp1 Napb Copb1 Napa Dctn3 Arfgap1 Tmed9 Spta1 Nsf Capzb Kdelr1 Cope Capza2 Sptbn1 Capza3 Arcn1 Kdelr2 Actr1a Gosr2 Gosr1 LOC100363782 Tmed10 Kdelr3 INTERLEUKIN-12 SIGNALING%REACTOME DATABASE ID RELEASE 66%10145676 Interleukin-12 signaling Il12rb1 Il12rb2 P4hb Il12b Jak1 Il12a Tyk2 Vamp7 NONSENSE-MEDIATED DECAY (NMD)%REACTOME%R-RNO-927802.1 Nonsense-Mediated Decay (NMD) Rnps1 LOC100912571 Magohb Rps20 Rps27l Rbm8a LOC100360573 Eif4g1 Rps4x LOC100359951 LOC100359593 Rpl30 Rpl4 LOC100359503 Rplp0 LOC100362640 Rpl6 Rpl13a Rpl26 Rps3 LOC100363800 Rps15a LOC685963 Rpl32 Rps2 Rps13 Gspt1 Rps12 Pnrc2 Pabpc2 Pabpc6 LOC100911372 Rplp1 LOC100361854 Rpl39 LOC684988 Rpl38 LOC103689992 Gspt2 Rps5 Rpl22 Rps7 Rpl23 Rpl10l Rps6 Smg8 Upf1 Rpl15 RGD1563300 Rpl19 Rpl10a Smg9 LOC100362830 LOC690468 Rpl29 LOC100363012 Smg7 Smg6 LOC680559 Smg5 Rpl39l LOC100362149 Upf3b Rpl41 LOC100912182 LOC100360057 Upf3a Rpl36al Etf1 Rpl13 Rpl3l Rpl36a Dcp1a Rps16 Ppp2ca Ppp2r1a LOC100911431 Pabpc1 Rps18 LOC100360679 Rps15 Magoh Rps3a Ncbp2 Ncbp1 Eif4a3 Ppp2r2a REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE%REACTOME%R-RNO-3371453.1 Regulation of HSF1-mediated heat shock response Nup93 Dnajb6 Nup43 Nup98 Nup133 l7Rn6 Nup107 Aaas Nup210 Npap60 Hspa14 Hspa13 Nup35 Nup37 Dnajc7 Nupl2 Ccar2 Nupl1 Hsph1 Atm Hspa12b Hspa12a Rpa3 Atr Nup205 Ranbp2 Dnajb1 Hsf1 Hspa1l Nup155 Hspa2 Rpa1 Nup88 Rpa2 Nup85 Ywhae Nup153 Bag1 Bag2 Bag4 Bag5 Bag3 Tpr Hspa9 Hspa5 Rae1 Mapkapk2 Hspa4 Mapk1 Nup54 Pom121 Nup62 TRANSCRIPTIONAL REGULATION BY TP53%REACTOME DATABASE ID RELEASE 66%10144748 Transcriptional Regulation by TP53 Rfc2 Gtf2h1 Gtf2h2 Usp7 Mdm2 Banp Mnat1 RGD1565904 Cdk5 Csnk2a2 Polr2g Polr2h Polr2e Polr2f Polr2j Csnk2a1 Polr2k LOC685619 Polr2d Polr2i Pml Polr2b Polr2c Polr2a LOC100912534 Triap1 Ell Rpa3 Tp53bp2 Atp5c1 Tcea1 Pcna Brca1 Taf7l Blm Ccnh Mapkapk5 Pidd1 Gtf2h3 Rfc5 Rfc4 Rfc3 Gtf2h5 Gtf2h4 Ing2 Ccnt2 Tceb3 Cdk9 Akt1 Hdac1 Ercc3 Brpf3 Rpa1 Nuak1 Rpa2 Hipk2 Brpf1 Ccnk Brd1 Supt5h LOC100911822 Taf7 Taf3 Ercc2 Taf6 Kat6a Taf5 Ing5 Tp53inp1 Zfp420 LOC100911519 Tp63 Cdkn1a Cdkn1b Chm Nelfe Nelfa Nelfb Cradd Bnip3l Gadd45a Bax Slc25a16 Ssrp1 L3mbtl1 Map2k6 Dyrk2 Rabggta Tp53rk Supt16h Aurka Cdc25c Aurkb Rabggtb Cdk5r1 Prelid1 Taf11 Taf15 Ppp2r5c Gpi Taf13 Taf12 Taf4b Noc2l Supt4h1 Pou4f2 Cdk7 Hipk1 Pdpk1 Ppp1r13b LOC100910137 Ppp1r13l Ttc5 Rhno1 Bard1 Wrn Topbp1 Rbbp8 Rmi1 Rmi2 Rad50 LOC364561 Pin1 Brd7 Ccna2 Plk2 Sesn2 Ccna1 Txnrd1 Ccne2 Plk3 Rffl Sesn1 Ccng1 Ccne1 RragB Tp73 Prkab1 Phf20 Sesn3 Atm Prkab2 Rictor Gsr Atrip E2f7 Cdk2 E2f8 Btg2 Tceb2 Cnot6l Tceb1 Cnot11 Rad1 Atr Rad17 Setd8 Tmem55b Rad9a Pip4k2b Nbn Pip4k2c Rad9b Mre11a Hus1 Tnks1bp1 Cnot8 Rqcd1 Cnot3 Ppp2cb Cnot1 Ywhah Ppp2ca Ywhag Cnot2 Sfn Ppp2r1a Ywhaz Cnot7 Cnot4 Ywhab Ywhaq Ywhae Mtor Prdx1 Ddit4 Rheb Prkag3 Rptor Lamtor4 LOC502894 Tsc1 Lamtor5 Ppp2r1b Txn1 Mlst8 Prkaa1 Tsc2 Rraga Prkaa2 Rragc Akt3 Rragd Slc38a9 Mapk14 Mapk11 Prmt5 Lamtor3 Gtf2f1 Gtf2f2 Lamtor2 Lamtor1 Hdac2 Mbd3 Chd3 Hdac1l Chd4 Zfp385a Mta2 Gatad2a Tbp Akt2 Gatad2b Meaf6 LOC100909949 Smyd2 Rbbp7 Ehmt2 Ehmt1 Cdk12 Taf2 Cenpj Slmo1 Taf9 Cdk13 Casp2 Csnk2b Usp2 Tpx2 Daxx LOC100910954 Cdk1 Mdm4 Chek2 Taf10 Rnf34 Mapkap1 Sgk1 Taf9b ROBO RECEPTORS BIND AKAP5%REACTOME%R-RNO-9010642.1 ROBO receptors bind AKAP5 Robo3 Akap5 Prkca INTERLEUKIN-35 SIGNALLING%REACTOME DATABASE ID RELEASE 66%10145680 Interleukin-35 Signalling Il12rb2 Canx Stat1 Il6st Jak1 Il12a Stat3 Tyk2 Ebi3 Il27ra TRANSLATION%REACTOME%R-RNO-72766.1 Translation Mrps11 LOC100912571 Mrps12 Eif3l Mrps16 Eif2s3 Mrps14 Eif3m Mrps18b Eif3j Eif4ebp1 Mrps18c Mrps10 Eif3k Mrps18a Rps20 Mrps33 Rps27l Mrps34 Eif3e Eif3f Mrps21 Mrps35 Eif2b1 Mrps17 Eif3b Mrps15 Eif3a Mrps31 Eif3d Mrps30 Eif3c Mrps24 Mrps23 Mrps22 mrpl9 Mrps28 Mrps27 Mrps26 Mrps25 LOC100360573 Mrpl4 Eif2s1 Mrpl3 Eif2s2 Mrpl2 Eif4g1 Oxa1l Mtrf1l Rps4x LOC100359951 LOC100359593 LOC367117 Eif5 LOC100359503 LOC100362640 Rpl13a Rps3 Mrrf Rps15a Rps2 Mrpl1 Mrpl13 Gspt1 Rps13 Mrpl10 Rps12 Mrpl18 Pabpc2 Mrpl19 Pabpc6 Mrps9 LOC100911372 LOC100361854 Mrps2 LOC684988 Mrps5 LOC103689992 Gspt2 Mrps7 Rps5 Mrpl36 Rps7 Mrpl37 Mrpl20 Eif2b5 Rps6 Mrpl14 Eif2b3 Mrpl16 Eif2b4 Mrpl12 Eif3g Mrpl15 Eif3h Eif4a2 LOC100362830 Mrpl41 Eif1ax Mrpl35 Eif4a1 Mrpl40 LOC100363012 Mrpl33 LOC680559 Mrpl34 LOC100911110 Mrpl38 LOC100362149 Mrpl32 Mrpl27 N6amt1 Mrpl23 Mrpl28 Mrpl30 Mrpl21 Trmt112 Mrpl54 Mrpl46 Mrpl55 Mrpl44 Mrpl43 Etf1 Mrpl47 Mrpl49 Mrpl53 Mrpl48 Mrpl52 Mrpl51 Mrpl50 Apeh Rps16 LOC100911431 Pabpc1 Rps18 LOC100360679 Rps15 Eif4h Eif4b Rps3a Sar1a mrpl11 mrpl24 Chchd1 Dap3 Eral1 Gadd45gip1 Ict1 Eef2 Ptcd3 Ppa2 Gfm2 Gfm1 TP53 REGULATES TRANSCRIPTION OF CASPASE ACTIVATORS AND CASPASES%REACTOME%R-RNO-6803207.1 TP53 Regulates Transcription of Caspase Activators and Caspases Cradd LOC100911519 Pidd1 Casp2 Atm VISUAL PHOTOTRANSDUCTION%REACTOME%R-RNO-2187338.1 Visual phototransduction Opn1sw Dhrs3 Rlbp1 Cnga1 Gucy2f Pde6b Rcvrn Gucy2d Pde6a Rgs9 RGD1560341 Akr1b7 Akr1b8 Sdc2 Sdc3 Sdc4 Opn1mw Awat2 Stra6 Rdh10 Rdh16 Akr1c2 LOC100365958 LOC100362350 Akr1c3 Akr1c12l1 Ttr Guca1b Ppef1 Metap2 Metap1 Gnat1 Apob Akr1c19 Apoc2 Nmt1 Guca1a Apoe Cngb1 Apoa2 Rgs9bp Fnta Nmt2 Akr1c13 Sag Akr1c14 RGD1564865 Grk4 Akr1c12 Grk1 Fntb Akr1c1 Pde6g Agrn Gpihbp1 Pnlip Apoa1 Rpe65 Clps Dhrs9 Myo7a Sdr9c7 Hsd17b6 Gpc6 Gpc4 Gpc2 Rbp4 Gnb5 Lrp1 Lrp10 Gnb1 Rbp2 Tex12 Rbp1 Lrp8 Abca4 Apom Lrp12 Lpl Bco1 Rdh11 Lrat Gpc1 Bco2 Cyp4v3 Gngt1 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS%REACTOME DATABASE ID RELEASE 66%10145358 Role of phospholipids in phagocytosis Prkcd Fcgr1a Cd247 Pla2g6 Pld1 Pik3r1 Pld2 Pld4 Pik3r2 Ppapdc1a Pld3 Pik3cb Cd3g Ppapdc1b Plcg1 Fcgr2b LOC103693683 Fcgr2a Syk Fcgr3a TRAF6-MEDIATED INDUCTION OF TAK1 COMPLEX WITHIN TLR4 COMPLEX%REACTOME DATABASE ID RELEASE 66%10145767 TRAF6-mediated induction of TAK1 complex within TLR4 complex Cd14 LOC100910771 Tab2 Tab3 Tab1 Tlr4 Ticam2 Map3k7 Traf6 TRKA ACTIVATION BY NGF%REACTOME DATABASE ID RELEASE 66%10145140 TRKA activation by NGF Ntrk1 Ngf AQUAPORIN-MEDIATED TRANSPORT%REACTOME DATABASE ID RELEASE 66%10145007 Aquaporin-mediated transport Myo5b Prkar2b Prkar2a Rab11fip2 Avp Aqp7 Prkar1b Gnb3 Aqp11 Prkar1a Gnb5 Aqp4 Mip Aqp12a Gnb2 Rab11a Gnb1 Gng13 Gng12 Aqp1 Gng11 Prkaca Prkacb LOC100912034 Gnb4 Gng4 Gngt2 Gng5 Gngt1 Gng10 Gng8 Gng3 CHK1 CHK2(CDS1) MEDIATED INACTIVATION OF CYCLIN B:CDK1 COMPLEX%REACTOME%R-RNO-75035.1 Chk1 Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex Wee1 Ywhah Ywhag Sfn Cdc25c Ywhaz Cdk1 Ywhab Chek2 Ywhaq Ywhae NEURONAL SYSTEM%REACTOME DATABASE ID RELEASE 66%10144791 Neuronal System Plcb1 Cacna1e Mdm2 Plcb3 Rims1 Gja10 Cplx1 Panx1 Syt1 Gjd2 Vamp2 Stxbp1 Kcnd3 Ppfia1 Ppfia2 Gjc1 Ppfia3 Kcnd1 Ppfia4 Slc38a2 Il1rap Maoa Slc22a1 Slc22a2 Aldh2 Comt Slc6a4 Slc6a3 Bche Lrtomt Chat Gnai3 Ache Slc1a3 Slc1a7 Slc1a6 Slc1a1 Kcnk6 Kcnk7 Nsf Myo6 Kcnj16 Flot1 Flot2 Rtn3 Chrne Kcnv2 Chrnd Kcnv1 Cacnb4 Stx1a Cacnb1 Cacng8 Cacnb2 Kcnq1 Cacna2d3 Prkca Cacng2 Ntrk3 Cacng3 Cacna2d2 Slc5a7 Cacng4 Dlg4 Grin2d Camk2g Grin2b Grm1 Grin1 Nefl Rasgrf1 Dlg1 Kcnmb4 Dlg2 Kcnmb3 Kcnn2 Kcnn3 Dlg3 Camk2d Actn2 Kcnmb2 Kcnmb1 Camk2a Lin7c Rps6ka2 Lin7a Rps6ka1 Syn3 Syn2 Rps6ka3 Lrrc4b Kcnn4 Chrna4 Kcnn1 Chrna5 Chrna9 Kcnma1 Lrfn2 Chrna6 Lrfn3 Chrnb2 Lrfn1 Chrna7 Lrfn4 Chrnb3 Syn1 Apba1 Chrna2 Chrna3 Chrna1 Ptprd Hcn1 Hcn3 Hcn2 Slitrk6 Slitrk5 Slitrk3 Slitrk2 Slitrk1 Ppfibp1 Ppfibp2 Ptprf Kcnk1 Kcnk13 Kcnk2 Kcnk3 LOC100909725 Kcnk4 Kcnk10 Gng10 Kcnk9 Rras Grip1 Grip2 Pick1 Lrrc7 Slc32a1 Slc38a1 Lin7b Gabra5 Gabra6 Gabrb1 Gabrg2 Gabra1 Gabra2 Kcnk18 Pdpk1 Naaa Gabra4 Gabrb2 Slc6a11 Dlgap2 Slc6a13 Dlgap3 Slc6a1 Dlgap4 Epb4.1l5 Slc6a12 Lrrtm2 Lrrtm3 Lrrtm4 LRRTM1 Raf1 Dlgap1 Ap2a2 Adcy8 Adcy9 Gad2 Adcy5 Adcy4 Kcnk16 Adcy7 Adcy6 Gad1 Abat Aldh5a1 Epb4.1 Gabrr1 Nrxn2 Shank1 Shank2 Gabrr3 Gabrr2 Nlgn1 Homer3 Nlgn2 Nlgn3 Homer2 Homer1 Epb41l2 Epb41l3 Gnal Rab3a Gnat3 Prkcb Kcnab2 Bzrap1 Ap2s1 Ap2a1 Ap2m1 Camkk1 Gnb3 Gnb5 Kcnc2 Gnb2 Gnb1 Gng13 Gng12 Gng11 Mapk1 Kcns3 Creb1 LOC100912034 Gnb4 Dbnl Camk4 Gng4 Gngt2 Gng5 Gngt1 Gng8 Gng3 Kcng4 Kcng3 Kcnq2 Kcna7 Chrnb4 Kcnb2 Kcns2 Kcnq3 Kcns1 Kcnh4 Kcnh3 Glra4 Kcnh2 Kcnab3 Kcna10 Htr3b Kcnf1 Htr3a Kcnh6 Glrb Kcnh5 Kcna1 Kcna2 Kcna5 Kcnc3 Kcnh1 Kcna4 Kcnj2 Kcnj3 Kcnj11 Kcnj14 Kcnj15 Glul Kcnj9 Abcc8 Cacna1b Kcnj5 Kcnj8 Gabbr1 Kcnj12 Gabbr2 Abcc9 Il1rapl1 Kcnj4 Kcnj6 Gria3 Gria4 Adcy3 Akap5 Dnajc5 Gnai2 Grik1 Grik3 Grik2 Ncald Grik5 Slc17a7 Rps6ka6 Hras Gnai1 SIGNAL REGULATORY PROTEIN FAMILY INTERACTIONS%REACTOME DATABASE ID RELEASE 66%10145430 Signal regulatory protein family interactions LOC100909977 Cd47 LOC100360575 Ptk2b Sirpa Tyrobp LOC100909879 Skap2 Grb2 Fyb RHO GTPASES ACTIVATE ROCKS%REACTOME%R-RNO-5627117.1 RHO GTPases Activate ROCKs Rock1 Rhoa Rock2 Rhob Rhoc TRIF(TICAM1)-MEDIATED TLR4 SIGNALING%REACTOME DATABASE ID RELEASE 66%10145138 TRIF(TICAM1)-mediated TLR4 signaling Map2k7 Ripk2 Tbk1 Map2k6 Ager Dusp3 Irf3 Map2k4 Map3k8 Dusp4 Nfkbib Traf6 Cul1 Vrk3 Rps6ka2 Rps6ka1 App Rps6ka3 Rps6ka5 LOC100912585 Tab1 Dusp7 Dusp6 Rela Atf1 Atf2 Map3k7 Irak2 Tlr4 Ikbke Tank Traf3 Nfkbia LOC100910771 Ube2n Jun Ppp2cb Ppp2ca Skp1 Ppp2r1a Ticam2 Nfkb2 Cd14 Nfkb1 Mapk9 Mapk8 Fos S100b Mapk7 Dhx9 Fbxw11 Chuk Ppp2r1b Mapkapk3 Btrc Mapkapk2 Mapk1 Nkiras1 LOC100362142 Nod1 Ptpn11 Nod2 Nkiras2 Creb1 Tab2 Tab3 LOC100912618 Ube2v1 Ikbkb Mapk14 Myd88 Tnip2 Mapk11 Mapk10 REGULATION OF TP53 DEGRADATION%REACTOME DATABASE ID RELEASE 66%10145361 Regulation of TP53 Degradation Usp7 Mdm2 Akt1 Ppp2r5c Ppp2cb Ppp2ca Ppp2r1a Ccna2 Ccna1 Rffl Ccng1 Phf20 Atm Rictor Mtor Usp2 Cdk2 Daxx LOC100910954 Cdk1 Ppp2r1b Mdm4 Mlst8 Chek2 Pdpk1 Rnf34 Mapkap1 Sgk1 Akt3 Akt2 VITAMIN B1 (THIAMIN) METABOLISM%REACTOME%R-RNO-196819.1 Vitamin B1 (thiamin) metabolism LOC100910173 Thtpa Tpk1 Slc19a2 Slc25a19 E3 UBIQUITIN LIGASES UBIQUITINATE TARGET PROTEINS%REACTOME%R-RNO-8866654.1 E3 ubiquitin ligases ubiquitinate target proteins Cdc73 LOC100910200 Hist1h2bh Ube2d1 Rtf1 LOC100912338 Leo1 Rnf40 Ube2d3 Ctr9 Hist1h2bq LOC100364835 Hist1h2bo Wdr61 Pex14 Hist1h2bcl1 Pex10 Pex13 Hist1h2bk Pex2 Pex12 Hltf Rad18 Pex5 Rraga Ube2a Pcna Rnf152 Ube2v2 Ube2n Shprh Bcl10 Rnf20 Hist1h2bg LOC103690024 LOC684797 Paf1 Hist1h2ba Rnf181 RESOLUTION OF D-LOOP STRUCTURES THROUGH SYNTHESIS-DEPENDENT STRAND ANNEALING (SDSA)%REACTOME DATABASE ID RELEASE 66%10146147 Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Bard1 Wrn Rbbp8 Rmi1 Rmi2 Rad51c LOC100911267 Rad51d Rad51 Brca2 Rad50 Rtel1 Xrcc3 Brca1 Blm Slc25a16 Palb2 Xrcc2 Nbn Atm Mre11a TWIK RELATED POTASSIUM CHANNEL (TREK)%REACTOME DATABASE ID RELEASE 66%10145838 TWIK related potassium channel (TREK) Kcnk2 Kcnk4 Kcnk10 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME DATABASE ID RELEASE 66%10145438 Regulation of beta-cell development Akt3 Foxo1 Akt1 Akt2 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND%REACTOME%R-RNO-69183.1 Processive synthesis on the lagging strand Rpa3 LOC100911727 Pold2 Pold1 Pcna Pold4 Rpa1 Slc25a16 Rpa2 Fen1 Prim2 Pola2 Prim1 Lig1 CARBOXYTERMINAL POST-TRANSLATIONAL MODIFICATIONS OF TUBULIN%REACTOME%R-RNO-8955332.1 Carboxyterminal post-translational modifications of tubulin Ttll9 Ttll4 Ttll5 Ttll3 Ttll7 Ttll2 Ttll10 Ttll12 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME DATABASE ID RELEASE 66%10145218 APC C:Cdc20 mediated degradation of mitotic proteins Psmc6 Psmb10 Psmb8 Psmb9 Psmb4 Psmb11 Bub3 Psmb5 Psmf1 Psmb6 Psmd4 Psmb2 Psmd5 Psmd8 Psmd9 Psmb3 Psma8 Psmd11 Psmd12 Anapc11 Ccna2 Ccna1 Anapc15 Psmd13 Anapc10 Psmd14 Psmc3 G6pc Ube2d1 Cdc20 Psmb7 Psmb1 Bub1b Mad2l1 Anapc7 Cdc26 Cdc27 Cdc23 Psma5 Pttg1 Ube2c Cdk1 Anapc16 Cdc16 Nek2l1 Anapc4 Psma2 Anapc2 Anapc1 Psmc5 Psmd2 Psma1 Psma4 Psmc1 Psma3 Psmc4 Psmc2 Psma6 Psme1 Nek2 Psmd1 Psme2 Psmd7 Psmd3 Psmd6 DEGRADATION OF AXIN%REACTOME DATABASE ID RELEASE 66%10146020 Degradation of AXIN Psmc6 Psmb10 G6pc Psmb8 Psmb9 Psmb4 Psmb11 Psmb5 Psmf1 Psmb6 Psmd4 Psmb2 Psmd5 Psmd8 Psmb7 Psmd9 Psmb1 Psmb3 Psma8 Psmd11 Psmd12 Psmd13 Psmd14 Tnks Psma5 Psma2 Psmc5 Psmc3 Psma1 Psmd2 Psma4 Psmc1 Psma3 Psmc4 Psmc2 Psma6 Psme1 Psmd1 Psme2 Tnks2 Psmd7 LOC100910717 Psmd3 Psmd6 DNA DAMAGE BYPASS%REACTOME DATABASE ID RELEASE 66%10144978 DNA Damage Bypass Rfc1 Rfc2 Pole2 Pole4 Polh Wdr48 Ddb1 Vcp Rbx1 Ns5atp9 Poli Zbtb32 Uba7 Usp43 Rev1 Rpa1 Rpa2 Ube2l6 Rchy1 Dtl Rpa3 Rad18 Pole Pold2 Pcna Pold1 Cul4b Pold4 Cul4a Usp1 Isg15 Trim25 Sprtn Rfc5 Nploc4 Usp10 Mad2l2 Rfc4 Rev3l Ufd1l Rfc3 SIGNALING BY ACTIVIN%REACTOME%R-RNO-1502540.1 Signaling by Activin Smad3 Fstl3 Smad2 Acvr2a Foxh1 Acvr1c Acvr1b Fst Inhba Drap1 CELL DIVISION%REACTOME%R-RNO-68884.1 cell division Stag1 Kif20a Kif23 Pds5b Pds5a Rad21 Smc1a Mau2 Stag2 Smc3 OAS ANTIVIRAL RESPONSE%REACTOME DATABASE ID RELEASE 66%10146284 OAS antiviral response Ddx58 Pde12 Oasl Rnasel Abce1 PKA-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%R-RNO-111931.1 PKA-mediated phosphorylation of CREB Adcy8 Adcy9 Adcy5 Adcy4 Adcy7 Adcy6 Prkar1b Prkar1a Prkaca Prkacb Adcy3 Prkar2b Prkar2a RHO GTPASES ACTIVATE WASPS AND WAVES%REACTOME DATABASE ID RELEASE 66%10145928 RHO GTPases Activate WASPs and WAVEs Wasf1 Arpc4 Abi1 Arpc3 Abi2 Potef Rac1 Nck1 Nckipsd LOC100361457 Actr3 Was Actr2 Arpc1b Cyfip1 Actb LOC100909750 Brk1 Baiap2 Cdc42 Mapk1 Arpc5 Wasl Nckap1l Wipf1 Ptk2 Wipf2 Wipf3 Actg1 Cyfip2 Nckap1 Abl1 Grb2 SNRNP ASSEMBLY%REACTOME%R-RNO-191859.1 snRNP Assembly Nup93 Nup43 Snrpf Nup98 Nup133 Nup107 Phax Aaas Nup155 Nup210 Snrpd1 Npap60 Snrpd2 Nup35 Snrpd3 Nup88 Snupn Nup37 Nupl2 Nupl1 Nup85 Nup153 Ncbp2 Ncbp1 Tpr Ddx20 Gemin7l1 Rae1 Tgs1 Gemin5 Gemin7 Gemin6 Nup54 Gemin8 Smn1 Pom121 Nup205 Ranbp2 Gemin2 Nup62 Snrpb CHROMOSOME MAINTENANCE%REACTOME DATABASE ID RELEASE 66%10145113 Chromosome Maintenance Rfc1 Cenpn Rfc2 Cenpl Cenpo Cenpt Pole2 Pole4 Cenpu Cenpk Cenph Cenpi Prim2 Pola2 Prim1 Cenpm Tinf2 Hist1h2bo Hist1h2bcl1 Hist1h2bk Rpa3 Pole Pcna Cenpc Cenpa Terf2ip Cenpw Ruvbl1 Smarca5 LOC100911204 Rfc5 Rfc4 Rfc3 Itgb3bp LOC100910200 H2afx Hist1h4b Mis18bp1 Acd Hist1h2bh LOC100912290 Rbbp7 Pot1b Hist1h4m LOC103690002 Tert LOC100910152 Pot1 LOC100912338 H2afb3 Rpa1 Hist2h4 Hjurp Rpa2 H2afj Hist2h2aa3 Hist1h2bq Hist2h2aa2 Casc5 LOC100364835 Lig1 LOC100911727 Terf1 Terf2 Pold2 Pold1 Pold4 Slc25a16 Fen1 Hist1h2bg LOC680097 LOC684797 LOC100912418 Hist1h2ba Hist3h2bb TRANSCRIPTIONAL REGULATION BY RUNX1%REACTOME DATABASE ID RELEASE 66%10146236 Transcriptional regulation by RUNX1 Psmc6 Psmb10 Psmb8 Psmb9 Psmb4 Psmb11 Psmb5 Psmf1 Psmb6 Mnat1 Psmd4 Psmb2 Psmd5 Psmd8 Csnk2a2 Psmd9 RGD1308751 Gata2 Psmb3 LOC100911167 Psma8 Psmd11 Psmd12 Csnk2a1 Tal1 Ldb1 Psmd13 Pml Psmd14 Tp73 Gata1 Actl6a Lmo2 Lmo1 Cts8l1 LOC100909750 Elf1 Elf2 Psmc3 Ccnh Yap1 Rbbp5 Actl6b Smarce1 Pbrm1 Arid1b Arid1a Zfpm1 Smarcd1 Hdac1 Smarcd2 Smarcd3 Foxp3 Ccnd1 Hipk2 Phc1 Phc2 MGC114246 Yaf2 Sin3a Sin3b Testin Prmt6 Hist1h2bo Scmh1 Hist1h2bcl1 Hist2h3c2 Cbx4 Hist1h2bk Cbx2 H3f3b Cbx8 Cbx6 Bmi1 Rnf2 Ring1 Smarca4 Hdac1l Prmt1 Smarca2 Phc3 LOC100911617 LOC100364523 Esr1 Arid2 Cbfb Gata3 Smarcc1 Smarcc2 Crebbp Smarcb1 Serpinb13 Cdk6 Abl1 Runx1 LOC100910200 Ccnd3 H2afx Hist1h4b Wdr5 Auts2 Kmt2a LOC684841 G6pc Pax5 Hist1h2bh Pcgf5 LOC100912290 Hist1h2ail1 Hist1h4m LOC102549173 LOC103690002 LOC100910152 Psmb7 LOC100912338 Hist1h3c Psmb1 H2afb3 Hist1h3f Ctsl Hist2h4 Ctsm LOC684819 Hist1h3a Ctsj H2afj RGD1564657 Hist2h2aa3 Hist1h2bq Ctsk Hist2h2aa2 Ctsq Ctsr Ash2l LOC100364835 Dpy30 LOC684762 Csnk2b Psma5 Cdk7 Psma2 Psmc5 Psmd2 Psma1 Psma4 Ptpn11 Psmc1 Psma3 Cts8 Psmc4 Cts7 Psmc2 Psma6 Psme1 Hist1h2bg Psme2 Psmd1 LOC680097 Psmd7 RGD1564827 LOC684797 LOC100912418 Hist1h2ba Psmd3 Hist3h2bb Psmd6 AFLATOXIN ACTIVATION AND DETOXIFICATION%REACTOME DATABASE ID RELEASE 66%10145070 Aflatoxin activation and detoxification Cyp3a23/3a1 Cyp3a73 Dpep2 Dpep3 Dpep1 Acy3 Akr7a2 Cyp3a18 LOC100910877 Ggt7 Ggt6 Cyp1a2 Mgst3 Mgst1 Acy1 SEROTONIN AND MELATONIN BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 66%10145426 Serotonin and melatonin biosynthesis Aanat Asmt Tph1 Tph2 Ddc N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI%REACTOME%R-RNO-975576.1 N-glycan antennae elongation in the medial trans-Golgi Mgat2 Mgat5 Man2a1 Fut8 Man2a2 Mgat4b Mgat3 Mgat4a B4galt1 Chst8 B4galt3 St6gal1 Lhb B4galt2 B4galt6 B4galt4 B4galt5 Chst10 St8sia3 St3gal4 Cga HYDROLYSIS OF LPE%REACTOME%R-RNO-1483152.1 Hydrolysis of LPE LOC686302 Pla2g4c Pla2g4cl1 ACTIVATED NTRK3 SIGNALS THROUGH PI3K%REACTOME%R-RNO-9603381.1 Activated NTRK3 signals through PI3K Src Ntrk3 Ntf3 SIGNAL TRANSDUCTION BY L1%REACTOME%R-RNO-445144.1 Signal transduction by L1 Csnk2b Ncam1 Egfr Nrp1 Rac1 Fgfr1 Mapk1 Csnk2a2 L1cam Pak1 Csnk2a1 Itga2b Vav2 Map2k2 PDE3B SIGNALLING%REACTOME%R-RNO-165160.1 PDE3B signalling Pde3b IRS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 66%10144880 IRS-mediated signalling Pik3r1 Pik3r2 Fgf23 Fgf22 Fgf4 Fgf1 Fgf3 Tlr9 Fgf6 Fgf5 Fgf20 Gab1 Pde3b Fgf16 Pik3c3 Fgf17 Irs2 Fgf10 Fgf9 Fgfr2 Fgf7 Fgf2 Fgf8 Fgfr3 Pik3r4 Trib3 Pdpk1 Fgfr1 Fgfr4 Pik3cb Ptpn11 Fgf19 Them4 Irs1 Frs2 Sos1 Akt2 Grb2 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE%REACTOME DATABASE ID RELEASE 66%10145154 Toll Like Receptor 7 8 (TLR7 8) Cascade Map2k7 Ripk2 Map2k6 Ager Dusp3 Map2k4 Map3k8 Dusp4 Peli3 Nfkbib LOC100912399 Peli2 Map3k1 Traf6 Cul1 Vrk3 Rps6ka2 Rps6ka1 App Rps6ka3 Rps6ka5 Tlr9 LOC100912585 Tab1 Dusp7 Dusp6 Rela Atf1 Atf2 Map3k7 Peli1 Irak2 Nfkbia LOC100910771 Ube2n Jun Ppp2cb Ppp2ca Skp1 Ppp2r1a Nfkb2 Nfkb1 Mapk9 Tlr7 Mapk8 Tlr8 Fos S100b Irak4 Mapk7 Dhx9 Fbxw11 Chuk Ppp2r1b Ecsit Mapkapk3 Btrc Mapkapk2 Dhx36 Mapk1 Nkiras1 LOC100362142 Nod1 Nod2 Nkiras2 Creb1 Tab2 Tab3 LOC100912618 Ube2v1 Ikbkb Mapk14 Myd88 Tnip2 Mapk11 Mapk10 ATP SENSITIVE POTASSIUM CHANNELS%REACTOME DATABASE ID RELEASE 66%10145831 ATP sensitive Potassium channels Kcnj11 Abcc8 Kcnj8 Abcc9 COOPERATION OF PDCL (PHLP1) AND TRIC CCT IN G-PROTEIN BETA FOLDING%REACTOME DATABASE ID RELEASE 66%10146196 Cooperation of PDCL (PhLP1) and TRiC CCT in G-protein beta folding Cct6b Gnai3 Rgs9 Csnk2a2 Gnat3 Gnao1 Cct6a Csnk2a1 Tcp1 Cct7 Rgs7 Cct4 Gnat2 Pdcl Gnaz Cct3 Csnk2b Gnai2 Gnb3 Gnb5 Cct2 Gnb2 Gnb1 Gng13 Gng12 Gng11 Gnat1 Cct8 LOC100912034 Gnb4 Gng4 Gngt2 Gnai1 Gng5 Gngt1 Gng10 Gng8 Gng3 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS%REACTOME DATABASE ID RELEASE 66%10145334 NRIF signals cell death from the nucleus Sqstm1 Ngf Aph1b Psenen Aph1a Ngfr LOC100911293 Psen2 Psen1 Traf6 Ncstn Itgb3bp CD209 (DC-SIGN) SIGNALING%REACTOME%R-RNO-5621575.1 CD209 (DC-SIGN) signaling Nfkb1 Kras Fyn Cd209a Raf1 Prkaca Prkacb Relb Rps6ka5 Pak2 Pak3 Pak1 Lyn Hras Cd209b Cd209e Rela Nras Crebbp Clec4m Icam2 ANTIMICROBIAL PEPTIDES%REACTOME%R-RNO-6803157.1 Antimicrobial peptides Slc11a1 RatNP-3b Try4 Ear1 RGD1306474 Bpifb2 Rnase17 Bpi Cd4 Atp7a LOC683849 Bpifa2 Rnase6 Np4 Bpifa1 Clu Prss2 Defa7 Defa11 Bpifb4 Pglyrp3b Defa10 Pglyrp3 Defa5 Bpifb6 Pglyrp4 Pglyrp2 Itln1 Eppin Bpifa2f Chga Bpifa5 Prss1 Reg3g Elane Defb26 Defb28 Ccr6 Defb30 Defb18 Pdzd11 Defb36 Defb14 Defb12 Atox1 Pla2g2a Defb29 LOC103690254 Defb49 Tlr10 Try10 Defb25 LOC100365995 Defb43 Defb44 Ctsg Rnase3 Rnase2 Art1 Defb13 Defb41 Defb1 Defb22 Defb23 Defb20 Defb21 LOC102554637 S100a8 Ltf Pglyrp1 Tlr2 VITAMIN C (ASCORBATE) METABOLISM%REACTOME DATABASE ID RELEASE 66%10145368 Vitamin C (ascorbate) metabolism Gsto2 Gsto1 Slc2a1 Cyb5r3 Slc23a2 Cyb5a DEUBIQUITINATION%REACTOME DATABASE ID RELEASE 66%10145726 Deubiquitination Usp7 Mdm2 Ddb2 Mysm1 Kat2a Yy1 Actr8 Keap1 Fkbp8 Stambp Uimc1 Actl6a Mcrs1 Actb Ino80 Brca1 Tomm70a Mul1 Tomm20 Ruvbl1 Usp8 Smad3 Smad2 Hist1h2aa Nedd8 Usp9x Ube2d1 Nlrp3 Usp47 Skp2 Usp48 Usp42 Becn1 Traf2 Usp20 Ripk2 Usp26 Usp21 Usp22 Traf6 Usp19 Usp37 Il33 Tab1 Usp30 Map3k7 Usp24 Usp25 Vdac1 Siah2 Traf3 Stam2 Nfkbia Usp14 LOC100910771 Usp18 Usp15 Usp11 Usp10 Ufd1l Stam Atxn3 G6pc Atxn7 Cdc20 Psmb7 Psmb1 Vdac2 Foxo4 Ino80e Ino80d Nfrkb Psma5 Rad23a Rad23b Psma2 Psmd2 Psmc2 Psmd1 Psmd7 Ino80b Psmd3 Ino80c Psmd6 Psmc6 Bard1 Wdr20 Pten Psmb10 Psmb8 Psmb9 Psmb4 Rnf123 Psmb11 Psmb5 Wdr48 Psmf1 Psmb6 Psmd4 Bre Psmb2 Psmd5 Psmd8 Psmd9 Psmb3 Brcc3 Psma8 Psmd11 Psmd12 Ccna2 Ccna1 Psmd13 Psmd14 Ccp110 Clspn Hif1a Rhot1 Psmc3 Uchl3 Bap1 Senp8 RGD1561252 Ptrh2 Asxl2 Tada3 Foxk2 Uchl5 Adrm1 Uchl1 Mat2b Babam1 Josd2 Josd1 Suds3 Tada2b Tnks Rce1 Nod1 Nod2 Usp3 Usp4 Usp5 Stambpl1 LOC100911959 Tnip2 Apc Otub1 Ide Otud3 Hist2h2ab Otud7b Vcp Zranb1 Ripk1 Ifih1 Vcpip1 Tnip1 RGD1565607 Otub2 LOC100911993 Tnfaip3 LOC689730 Tgfbr1 Bmyc Usp13 Polb Esr1 Ogt Gata3 Tnks2 LOC100910717 Birc3 Birc2 Cyld LOC100910107 Ddx58 Fam175b Hist2h2aa3 Hist2h2aa2 Usp33 Usp2 Fam175a LOC100910954 Cdk1 Mdm4 Taf10 Psmc5 Arrb1 Psma1 Psma4 Psmc1 Arrb2 Cdc25a Rhoa Psma3 Psmc4 Psma6 Psme1 Psme2 LOC100912059 Adrb2 Usp17l5 Taf9b AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS%REACTOME DATABASE ID RELEASE 66%10145371 AKT phosphorylates targets in the nucleus Akt3 Rps6kb2 Creb1 Foxo1 Nr4a1 Foxo3 Foxo4 Akt1 Akt2 INFLAMMASOMES%REACTOME DATABASE ID RELEASE 66%10145733 Inflammasomes Nlrp3 Aim2 Hsp90ab1 Txn1 Panx1 Sugt1 Pycard Bcl2 Nlrp1a Txnip Mefv Pstpip1 P2rx7 PROCESSING OF SMDT1%REACTOME%R-RNO-8949664.1 Processing of SMDT1 Pmpcb Pmpca MGC94335 Afg3l2 Micu3 Stoml2 Micu2 LOC100910779 Micu1 Yme1l1 Spg7 Phb2 LOC100362065 Ccdc109b Mcu COPII-MEDIATED VESICLE TRANSPORT%REACTOME%R-RNO-204005.1 COPII-mediated vesicle transport Areg Stx5 Bet1 Sec24a Sec24b Cnih1 Sec24d Trappc10 Ppp6c Cnih3 Cnih2 Trappc2l Tgfa Cd59 Trappc6a Sec23ip Trappc6b Lman1l LOC102555167 Ankrd28 Sec13 Sar1b Col7a1 Rab1b Rab1a Lman2 Ykt6 F8 Sec16a Sec24c Scfd1 Sec16b Lman1 Folr1 Trappc2 Trappc5 Tmed2 Ctsc Uso1 Napg Gorasp1 Ctsz Napb Napa Tfg Mcfd2 Preb Nsf Trappc3 LOC100910318 Sec22b Tbc1d20 Sec23a Sec31a Sec22a Stx17 Csnk1d Gosr2 Ppp6r3 LOC100363782 Ppp6r1 Tmed10 Trappc1 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME DATABASE ID RELEASE 66%10145773 IRAK2 mediated activation of TAK1 complex upon TLR7 8 or 9 stimulation LOC100910771 Tab2 Tab3 Tab1 Map3k7 Traf6 Irak2 BIOSYNTHESIS OF DPAN-3 SPMS%REACTOME%R-RNO-9025094.1 Biosynthesis of DPAn-3 SPMs Alox12 Alox5 Ptgs2 Alox15 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS%REACTOME DATABASE ID RELEASE 66%10144939 SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs Ncbp2 Slbp Snrpf Zfp473 Snrpd3 Ncbp1 Lsm10 Lsm11 Snrpb DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE%REACTOME%R-RNO-4641262.1 Disassembly of the destruction complex and recruitment of AXIN to the membrane Peg12 Frat2 Wnt8a Dvl1 LOC100361515 Wnt8b Fzd1 Lrp5 Lrp6 Dvl2 Wnt3 Dvl3 Fzd2 Wnt1 Wnt3a COLLAGEN DEGRADATION%REACTOME DATABASE ID RELEASE 66%10145855 Collagen degradation Mmp8 Mmp15 Mmp7 Col19a1 Mmp12 Mmp14 Mmp9 Col13a1 Try4 Mmp13 Mmp1 LOC103690254 Mmp2 Try10 LOC100365995 Ctsd Ctsb RGD1308751 Ctsm Ctsj Phykpl RGD1564657 Ctsk Ctsq Ctsr LOC683849 Furin Col18a1 MGC114246 Cts8l1 LOC102554637 Mmp20 Tmprss6 Prss2 LOC100364523 LOC100910122 Testin Cts8 Cts7 Col26a1 RGD1564827 Prss1 Mmp10 PROTEIN REPAIR%REACTOME%R-RNO-5676934.1 Protein repair Msrb2 Msrb3 Txn1 Msra ACROSOME REACTION%REACTOME%R-RNO-1300645.1 Acrosome Reaction Acr PKA ACTIVATION%REACTOME%R-RNO-163615.1 PKA activation Adcy8 Adcy9 Adcy5 Adcy4 Adcy7 Adcy6 Prkar1b Prkar1a Prkaca Prkacb Adcy3 Prkar2b Prkar2a PROCESSING OF INTRONLESS PRE-MRNAS%REACTOME DATABASE ID RELEASE 66%10144941 Processing of Intronless Pre-mRNAs Ncbp2 Ncbp1 Cpsf7 Papola Wdr33 Cpsf2 Cpsf3 Cpsf4 Pcf11 Cstf2t Fip1l1 Sympk Cstf1 Cpsf1 Nudt21 Clp1 Cstf2 NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 66%10145491 Netrin-1 signaling Mapk8 Src Fyn Mapk13 LOC100909609 Mapk12 Dscaml1 Dscam Prkcq Siah1 Dcc Rac1 Siah2 Cdc42 Ezr Nck1 Pak1 Wasl Dock1 Ptk2 Ntn1 Mapk14 Ntn4 Mapk11 FMO OXIDISES NUCLEOPHILES%REACTOME%R-RNO-217271.1 FMO oxidises nucleophiles Fmo1 Fmo2 ASTROCYTIC GLUTAMATE-GLUTAMINE UPTAKE AND METABOLISM%REACTOME%R-RNO-210455.1 Astrocytic Glutamate-Glutamine Uptake And Metabolism Slc1a3 Slc38a1 Glul RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES%REACTOME%R-RNO-380270.1 Recruitment of mitotic centrosome proteins and complexes Dync1i2 Tubgcp2 Cep57 LOC691918 Haus3 Ninl Akap9 Ccp110 Dync1h1 Pafah1b1 LOC103692716 Dctn1 Cntrl Dctn2 Cep76 Pcm1 Cep78 LOC100911033 Cep164 Dctn3 Cep41 Ofd1 Sdccag8 Tubb5 Prkar2b Cenpj Ywhag Ppp2r1a Plk4 Ywhae LOC100912076 Tubg2 Haus2 Haus1 Haus5 Alms1 Cdk11b Haus4 Clasp1 Odf2 Tubb4a Cdk1 Nek2l1 Ssna1 Mapre1 Tubg1 Cep63 Prkaca Csnk1d Cep131 Tuba4a Cep250 Cep135 Csnk1e Ckap5 Cdk5rap2 Nme7 Tubgcp5 Pcnt Nek2 Tubgcp6 Cep72 Tubgcp3 Sfi1 Tubgcp4 Cep70 Actr1a Mzt1 Nedd1 Mzt2b METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS%REACTOME%R-RNO-196849.1 Metabolism of water-soluble vitamins and cofactors Mmadhc Abcd4 Cd320 Slc46a1 Mmab Tcn2 Mmachc LOC683849 Ctrc Lmbrd1 Fasn Acacb Nnmt Slc5a6 Mccc2 Nt5e Pdzd11 Mtrr Hlcs Gsto1 Mccc1 LOC103690254 Mtr Mut Try10 LOC100365995 Cubn Amn Naprt1 Ptgs2 Mmaa Ptgis Try4 LOC688708 Rfk Pdxk LOC100911034 Apoa1bp Gsto2 Vnn1 Tpk1 Rnls Carkd Slc52a2 Slc52a3 Slc23a2 Pc Nampt Mocs1 Cd38 Enpp1 Parp14 LOC100910173 Nudt12 Nmnat2 Nmnat1 Acp5 Mocos Nmrk1 Prss2 Nmrk2 Nfs1 Nadsyn1 Cyb5a Pank4 Flad1 Coasy Parp9 Mocs3 Pank3 Pank2 Parp6 Ppcs RGD1563242 Thtpa Pank1 LOC100362038 Parp8 Aasdhppt Qprt Folr2 Slc19a2 Nadk Prss1 Slc25a19 Aox1 Pnpo Ppcdc Mthfs Mthfd1l Mthfd2l Dhfr LOC102554637 Mthfr Mthfd2 Slc5a8 Mthfd1 Shmt1 Aldh1l2 Aldh1l1 Slc19a1 Slc25a32 Cyp8b1 Shmt2 Bst1 Slc2a1 Pccb Cyb5r3 CELLULAR RESPONSE TO HYPOXIA%REACTOME%R-RNO-2262749.1 Cellular response to hypoxia Psmc6 Psmb10 Hif1an Psmb8 Vhl Psmb9 Psmb4 Psmb11 Psmb5 Psmf1 Psmb6 Psmd4 Psmb2 Rbx1 Psmd5 Psmd8 Psmd9 Psmb3 Psma8 Psmd11 Psmd12 Psmd13 Psmd14 Egln2 Tceb2 Tceb1 Cul2 Cited2 Hif1a Limd1 Psmc3 Epas1 Hif3a Egln3 Ajuba Crebbp G6pc Ube2d1 Psmb7 Psmb1 Ube2d3 Psma5 Arnt Psma2 Psmc5 Psmd2 Psma1 Psma4 Psmc1 Psma3 Psmc4 Psmc2 Psma6 Psme1 Psmd1 Psme2 Psmd7 Psmd3 Psmd6 PHOSPHOLIPASE C-MEDIATED CASCADE; FGFR4%REACTOME DATABASE ID RELEASE 66%10146101 Phospholipase C-mediated cascade; FGFR4 Fgf16 Fgf17 Fgf9 Fgf2 Fgf8 Fgfr4 Fgf23 Fgf4 Fgf1 Fgf6 Plcg1 Fgf19 Fgf20 CROSSLINKING OF COLLAGEN FIBRILS%REACTOME DATABASE ID RELEASE 66%10145923 Crosslinking of collagen fibrils Bmp1 Loxl4 Tll2 Lox Loxl1 Tll1 Pcolce CELL SURFACE INTERACTIONS AT THE VASCULAR WALL%REACTOME DATABASE ID RELEASE 66%10145033 Cell surface interactions at the vascular wall Cd44 Selplg Sele Itgam Igll1 Cd244 Selp Cd84 Glg1 Slc7a8 Slc7a9 Mmp1 Slc7a5 Slc7a6 Gas6 Slc7a7 Itgb2 Itga4 Slc7a10 Vpreb2 Itga6 Vpreb1 Slc16a3 Sdc2 Vpreb3 Jam3 Sdc3 Slc16a8 Sdc4 Slc16a1 Epcam Mertk Esam Cd48 Mif Trem1 Ceacam1 Cd47 Fyn Apob Thbd Procr Itgal Tgfb1 F2 Itgax LOC100909879 Kras Grb7 Pf4 Dok2 Bsg Pik3r1 Pik3r2 F11r L1cam Cd74 LOC100360575 Sirpa Atp1b3 Fn1 Atp1b2 LOC100909977 Atp1b1 Fcer1g Itga3 Slc7a11 LOC288521 Pik3cb Ppil2 Tek Ptpn11 Pros1 Spn LOC100361537 Lyn Angpt1 Hras Nras Gpc1 Sos1 Mag Angpt2 Angpt4 Ceacam10 Shc1 Grb2 FORMATION OF THE EDITOSOME%REACTOME DATABASE ID RELEASE 66%10144942 Formation of the Editosome Apobec1 Apobec2 A1cf Apobec4 ACTIVATION OF NOXA AND TRANSLOCATION TO MITOCHONDRIA%REACTOME DATABASE ID RELEASE 66%10145050 Activation of NOXA and translocation to mitochondria Pmaip1 REGULATION OF THYROID HORMONE ACTIVITY%REACTOME DATABASE ID RELEASE 66%10145423 Regulation of thyroid hormone activity SODIUM-COUPLED SULPHATE, DI- AND TRI-CARBOXYLATE TRANSPORTERS%REACTOME DATABASE ID RELEASE 66%10145648 Sodium-coupled sulphate, di- and tri-carboxylate transporters Slc13a4 Slc13a1 Slc13a2 Slc13a3 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1%REACTOME%R-RNO-174178.1 APC C:Cdh1 mediated degradation of Cdc20 and other APC C:Cdh1 targeted proteins in late mitosis early G1 Psmc6 Psmb10 Psmb8 Psmb9 Psmb4 Psmb11 Psmb5 Psmf1 Psmb6 Psmd4 Psmb2 Psmd5 Psmd8 Psmd9 Psmb3 Psma8 Psmd11 Psmd12 Anapc11 Anapc15 Psmd13 Aurka Anapc10 Psmd14 Fzr1 Aurkb Psmc3 G6pc Ube2d1 Cdc20 Psmb7 Psmb1 Anapc7 Cdc26 Cdc27 Psma5 Cdc23 Pttg1 Ube2c Skp2 Anapc16 Cdc16 Anapc4 Psma2 Anapc2 Anapc1 Psmc5 Psmd2 Psma1 Psma4 Psmc1 Psma3 Psmc4 Psmc2 Psma6 Psme1 Psmd1 Psme2 Psmd7 Psmd3 Psmd6 BIOSYNTHESIS OF DPAN-3-DERIVED 13-SERIES RESOLVINS%REACTOME%R-RNO-9026403.1 Biosynthesis of DPAn-3-derived 13-series resolvins Alox5 TP53 REGULATES TRANSCRIPTION OF DEATH RECEPTORS AND LIGANDS%REACTOME%R-RNO-6803211.1 TP53 Regulates Transcription of Death Receptors and Ligands O2 CO2 EXCHANGE IN ERYTHROCYTES%REACTOME DATABASE ID RELEASE 66%10145818 O2 CO2 exchange in erythrocytes Cyb5r2 Cyb5rl Rhag Hbb-b1 Hba1 Car2 Aqp1 Slc4a1 Cyb5r1 Car1 LOC287167 FGFR2B LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 66%10145290 FGFR2b ligand binding and activation Fgf22 Fgf1 Fgf3 Fgf10 Fgfbp3 Fgfbp1 Fgfr2 Fgf2 Fgf7 RAF ACTIVATION%REACTOME DATABASE ID RELEASE 66%10146124 RAF activation Map3k11 Kras Src Ksr1 Ppp2r5e Raf1 Ppp2r1b Mark3 LOC100909468 Araf Ppp2r5c Ppp2cb Ppp2r5a Ppp2ca Ppp2r1a Ppp2r5b Hras Nras Ywhab Map2k2 ARMS-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 66%10145180 ARMS-mediated activation Ntrk1 Ngf Kidins220 Crk Rap1a GRB2 EVENTS IN EGFR SIGNALING%REACTOME%R-RNO-179812.1 GRB2 events in EGFR signaling Kras Hras Nras Egfr Sos1 Grb2 HS-GAG BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 66%10145730 HS-GAG biosynthesis Gpc6 Agrn Hs3st3a1 Gpc4 Gpc2 Ndst1 Ndst2 Ndst3 Ext1 Ndst4 Ext2 Hs6st2 Slc35d2 Hs3st3b1 Hs2st1 Hs3st5 Sdc2 Sdc3 Gpc1 Hs6st1 Sdc4 Hs3st2 Hs3st1 Hs3st6 STAT6-MEDIATED INDUCTION OF CHEMOKINES%REACTOME%R-RNO-3249367.1 STAT6-mediated induction of chemokines Tbk1 Stat6 Tmem173 DEGRADATION OF GABA%REACTOME DATABASE ID RELEASE 66%10145745 Degradation of GABA Abat Aldh5a1 BIOSYNTHESIS OF E-SERIES 18(R)-RESOLVINS%REACTOME DATABASE ID RELEASE 66%10146300 Biosynthesis of E-series 18(R)-resolvins Gpx4 Alox5 Alox15 Lta4h DNA DOUBLE STRAND BREAK RESPONSE%REACTOME%R-RNO-5693606.1 DNA Double Strand Break Response Bard1 Ppp5c Bre Rad50 Brcc3 Pias4 Uimc1 Atm Hist1h2bo Hist1h2bcl1 Hist1h2bk LOC100909750 Kdm4b Kdm4a Sumo1 Brca1 Bap1 Mdc1 Ube2v2 Ube2n Ube2i Smarca5 Nbn Abl1 Mre11a LOC100910200 Whsc1 H2afx LOC100359600 Hist1h4b Rnf8 Hist1h2bh LOC100912290 Eya3 Apbb1 Babam1 LOC686349 Tp53bp1 Eya2 Hist1h4m Eya4 LOC100912338 Herc2 Hist2h4 Hist1h2bq LOC100364835 Baz1b Mapk8 Fam175a LOC100910954 Chek2 Hist1h2bg LOC680097 LOC684797 LOC100912418 Hist1h2ba Hist3h2bb Kpna2 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN%REACTOME DATABASE ID RELEASE 66%10145192 Regulation of Glucokinase by Glucokinase Regulatory Protein Nup93 Nup43 Nup98 Nup133 Nup107 Tpr Aaas Nup155 Rae1 Nup210 Npap60 Nup54 Nup35 Nup88 Nup37 Pom121 Nupl2 Nup205 Ranbp2 Gckr Nup62 Nupl1 Nup85 Nup153 CYTOSOLIC SULFONATION OF SMALL MOLECULES%REACTOME%R-RNO-156584.1 Cytosolic sulfonation of small molecules Bpnt1 Abhd14b Slc35b2 Sult6b1 Podxl2 Sult4a1 Sult2a1 Slc35b3 Papss2 Papss1 LOC100910526 RGD1562392 ste2 Impad1 Slc26a2 Tpst1 Slc26a1 Tpst2 Sult2b1 NEWGENE_1306455 LOC100910057 Sult1b1 LOC100910881 Sult1a1 Sult1c2 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS%REACTOME%R-RNO-264870.1 Caspase-mediated cleavage of cytoskeletal proteins Casp3 Vim Mapt Casp6 Dbnl Add1 Plec Gas2 Gsn Sptan1 Casp8 DISPLACEMENT OF DNA GLYCOSYLASE BY APEX1%REACTOME%R-RNO-110357.1 Displacement of DNA glycosylase by APEX1 Tdg Mpg Ogg1 Mbd4 Smug1 Ung Apex1 Nthl1 Mutyh NICOTINAMIDE SALVAGING%REACTOME%R-RNO-197264.1 Nicotinamide salvaging Nnmt Parp14 Nudt12 Ptgis Slc5a8 Cyp8b1 Parp9 Apoa1bp Parp6 Naprt1 Parp8 Rnls Carkd Ptgs2 Nampt TELOMERE MAINTENANCE%REACTOME DATABASE ID RELEASE 66%10145112 Telomere Maintenance Rfc1 Rfc2 Pole2 Pole4 Prim2 Pola2 Prim1 Hist1h2bo Tinf2 Hist1h2bcl1 Hist1h2bk Rpa3 Pole Pcna Terf2ip Rfc5 Rfc4 Rfc3 LOC100910200 H2afx Hist1h4b Acd Hist1h2bh LOC100912290 Pot1b Hist1h4m Tert LOC103690002 LOC100910152 Pot1 LOC100912338 H2afb3 Rpa1 Hist2h4 Rpa2 H2afj Hist2h2aa3 Hist1h2bq Hist2h2aa2 Lig1 LOC100364835 Terf1 LOC100911727 Terf2 Pold2 Pold1 Pold4 Slc25a16 Fen1 Hist1h2bg LOC680097 LOC684797 LOC100912418 Hist1h2ba Hist3h2bb RECYCLING OF EIF2:GDP%REACTOME%R-RNO-72731.1 Recycling of eIF2:GDP Eif2s3 Eif2b5 Eif2b3 Eif2b4 Eif2s1 Eif2s2 Eif2b1 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE%REACTOME DATABASE ID RELEASE 66%10144920 Cytochrome P450 - arranged by substrate type Nr1h4 Cyp1b1 Cyp4a2 Cyp4a1 Ptgis Rxra Cyp4a8 Cyp19a1 Fdx1l Cyp2j10 Por Cyp7b1 LOC100360055 Cyp7a1 Cyp21a1 Fdxr Cyp46a1 Cyp2r1 Cyp4f17 Ncoa1 Cyp4f18 Cyp2b2 Cyp2c24 Cyp2s1 Cyp2b1 Cyp4f39 Tbxas1 Cyp39a1 Pomc Cyp2b3 Cyp2d5 Cyp26c1 Cyp51 Fdx1 LOC100361492 Ahr Cyp11b2 LOC100910127 Cyp27b1 Cyp2c13 LOC100361547 Cyp3a23/3a1 Ncoa2 Cyp3a73 Cyp2b21 Arnt Cyp4f6 Cyp2u1 Cyp8b1 LOC100911763 Cyp2c7 Cyp2b15 Cyp2e1 Cyp2b12 LOC100912391 Cyp2d4 Cyp24a1 Cyp2f4 Cyp3a18 Cyp26a1 Cyp1a1 LOC100910877 Cyp2d2 Arnt2 Cyp4v3 Cyp1a2 Cyp26b1 Cyp2d3 Cyp2c6v1 UB-SPECIFIC PROCESSING PROTEASES%REACTOME%R-RNO-5689880.1 Ub-specific processing proteases Psmc6 Wdr20 Pten Psmb10 Usp7 Mdm2 Ddb2 Psmb8 Psmb9 Rnf123 Psmb4 Psmb11 Psmb5 Kat2a Psmf1 Wdr48 Psmb6 Psmd4 Psmb2 Psmd5 Psmd8 Keap1 Psmd9 Psmb3 Fkbp8 Psma8 Psmd11 Psmd12 Ccna2 Ccna1 Psmd13 Psmd14 Ccp110 Clspn Hif1a Rhot1 Psmc3 Tomm70a Ptrh2 Mul1 Tada3 Tomm20 Ruvbl1 Adrm1 Mat2b Usp8 Smad3 Smad2 Usp9x Suds3 Tada2b Tnks Usp47 Usp48 Skp2 Rce1 Usp42 Becn1 Traf2 Usp3 Usp4 Usp5 LOC100911959 Usp20 Usp26 Usp21 Usp22 Otub1 Ide Traf6 Usp19 Usp37 Il33 Tab1 Usp30 Ripk1 Ifih1 RGD1565607 Map3k7 LOC100911993 Usp24 Usp25 Vdac1 LOC689730 Tgfbr1 Bmyc Usp13 Polb Siah2 Stam2 Nfkbia Usp14 LOC100910771 Gata3 Usp18 Usp15 Tnks2 Usp11 Usp10 LOC100910717 Ufd1l Birc3 Birc2 G6pc Cyld Atxn7 Cdc20 LOC100910107 Psmb7 Ddx58 Psmb1 Vdac2 Foxo4 Usp33 Usp2 Psma5 LOC100910954 Mdm4 Taf10 Psma2 Psmc5 Arrb1 Psma1 Psmd2 Psma4 Psmc1 Arrb2 Cdc25a Psma3 Psmc4 Psma6 Psmc2 Psme1 Psme2 Psmd1 Psmd7 LOC100912059 Adrb2 Psmd3 Usp17l5 Taf9b Psmd6 O-GLYCOSYLATION OF TSR DOMAIN-CONTAINING PROTEINS%REACTOME DATABASE ID RELEASE 66%10146044 O-glycosylation of TSR domain-containing proteins Adamts13 Adamts15 Adamts19 Pofut2 Adamts16 Adamts17 Adamts4 Adamts3 Adamts5 Adamts12 Sema5a Spon2 Spon1 Adamts1 Adamts6 Adamts7 Adamts9 Sspo Cfp Adamts14 Sema5b Thbs2 Thsd7a Thbs1 Adamtsl2 Adamtsl3 Thsd1 Adamtsl4 Thsd7b LOC102554393 Sbspon TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT%REACTOME DATABASE ID RELEASE 66%10144895 Transport of Mature mRNA derived from an Intron-Containing Transcript Nup93 Rnps1 Thoc5 RGD1565693 Thoc7 Thoc3 Nup43 Thoc2 Nup98 Nup133 Thoc1 Nup107 Magohb Aaas Rbm8a Thoc6 Nup210 Npap60 Nxf7 Nup35 Gle1 Nxf2 Nup37 Nxf1 Nupl2 Ddx39a Nupl1 Ddx39b Chtop U2af1l4 Sarnp Tcp11x2 Nup205 Nxt1 Ranbp2 Slu7 Srsf3 Upf3b U2af2 Srsf6 Nup155 Srsf7 Srsf4 Srsf5 Srsf2 LOC679894 Nup88 Srsf9 Dhx38 Nup85 Magoh Nup153 Ncbp2 Srsf1 Poldip3 Ncbp1 Tpr Fyttd1 Rae1 Eif4a3 LOC100910660 Srrm1 Nup54 Pom121 Nup62 Cdc40 LOC361990 MET ACTIVATES PI3K AKT SIGNALING%REACTOME%R-RNO-8851907.1 MET activates PI3K AKT signaling Gab1 Hgf Pik3r1 Grb2 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME DATABASE ID RELEASE 66%10145957 NOTCH2 intracellular domain regulates transcription Notch2 Maml1 Rbpj Rbpjl2 RET SIGNALING%REACTOME DATABASE ID RELEASE 66%10146221 RET signaling Src Grb7 Dok2 Pik3r3 Pik3r1 Pik3r2 Rap1gap Gfra4 LOC100912585 Gfra3 Gfra2 Dok4 Dok1 Dok6 Pik3cd Dok5 Artn Gab1 Shc3 Nrtn Mapk7 Irs2 Ret Prkaca Grb10 Pik3cb Prkacb Ptpn11 Prkca Gdnf Plcg1 Frs2 Pdlim7 Sos1 Shc1 Pspn Grb2 CLATHRIN-MEDIATED ENDOCYTOSIS%REACTOME DATABASE ID RELEASE 66%10146228 Clathrin-mediated endocytosis Igf2r Egfr Syt1 Vamp2 Dnm2 Ap2a2 Cttn Cops8 Amph Cops2 LOC100361515 Bin1 Nedd8 Synj1 Fnbp1 Wnt5a Cltc Cltb Clta Fzd4 Synj2 Ap2s1 Cops4 Cops6 Ap2a1 Ap2m1 Cops3 Rab5b Rab5c Pacsin2 Pacsin3 Pik3c2a Gak Agtr1b Agtr1a Syt11 Aak1 Sgip1 Eps15l1 LOC100909548 Itsn2 Scarb2 Necap1 Agfg1 Snap91 Snx18 Ubqln2 Picalm Tgoln2 Ldlr Tor1a Hip1r Ston2 LOC100909679 Tfrc RGD1307443 Tf Chrm2 Necap2 Cd4 Snx9 Fnbp1l Tor1b Avp Dab2 Ston1 Pip5k1c Gapvd1 Cbl Arf6 Hip1 Vamp8 LOC100910792 Stam2 Sh3gl2 Apob Sh3gl1 Sh3kbp1 Wasl Sh3gl3 Ocrl Stam Arpc4 Arpc3 Itsn1 Arfgap1 Actr3 Actr2 Dnm1 Dnm3 Cops7b Cops7a Arrb1 Cd3g Dvl2 Slc2a8 Syt8 Arrb2 Cd3d Syt9 Syt2 Arpc5 Fcho2 Fcho1 M6pr Ldlrap1 Adrbk1 Vamp4 Vamp3 Adrb2 Vamp7 Tacr1 Grb2 FGFR2 ALTERNATIVE SPLICING%REACTOME%R-RNO-6803529.1 FGFR2 alternative splicing RGD1565904 Hnrnph1 Polr2g Polr2h Polr2e Polr2f Polr2j Polr2k Polr2d LOC100911822 Polr2i Polr2b Polr2c Polr2a Ncbp2 Esrp2 LOC100912534 Gtf2f1 Esrp1 Gtf2f2 Rbfox2 Tia1 Ncbp1 Tial1 Hnrnpm Hnrnpf NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME DATABASE ID RELEASE 66%10145624 Negative epigenetic regulation of rRNA expression LOC100910200 H2afx Hist1h4b LOC684841 Hist1h2bh LOC100912290 Hist1h2ail1 Hist1h4m LOC102549173 LOC103690002 LOC100910152 LOC100912338 Hist1h3c H2afb3 Hist1h3f Hist2h4 LOC684819 Hist1h3a H2afj Rrp8 Hist2h2aa3 Hist1h2bq Suv39h1 Hist2h2aa2 LOC100364835 LOC684762 Hist1h2bo Hist1h2bcl1 Hist2h3c2 Hist1h2bk H3f3b Hist1h2bg Mbd2 LOC680097 LOC684797 LOC100912418 Hist1h2ba Suv39h1l1 Hist3h2bb C-TYPE LECTIN RECEPTORS (CLRS)%REACTOME%R-RNO-5621481.1 C-type lectin receptors (CLRs) Psmc6 Psmb10 Psmb8 Psmb9 Psmb4 Raf1 Psmb11 Psmb5 Psmf1 Psmb6 Psmd4 Psmb2 Psmd5 Psmd8 Psmd9 Psmb3 Psma8 Psmd11 Psmd12 Psmd13 Psmd14 Fyn Psmc3 Il1b Ube2n Bcl10 Src Ube2d1 Skp1 Ppp3r1 Nfkb2 Nfkb1 Fbxw11 Chuk Btrc Prkaca Prkacb LOC100362142 Tab2 Tab3 LOC100912618 Lyn Ube2v1 Ikbkb Traf6 Cul1 Rps6ka5 Tab1 Cdc34 Rela Map3k7 Ube2m Pak2 Nfkbia Pak3 LOC100910771 Pak1 Pycard Crebbp Prkcd Kras G6pc Psmb7 Psmb1 Cd209b Cd209e Clec4m Casp8 Psma5 Cd209a Pdpk1 Psma2 Psmc5 RGD1560225 Psma1 Uba3 Psmd2 Ppp3ca Psma4 Nfatc2 Map3k14 Relb Psmc1 Psma3 Psmc4 Psma6 Psmc2 Psme1 Psmd1 Hras Psme2 Psmd7 Nras Nfatc3 Icam2 Psmd3 Psmd6 TRANSPORT OF CONNEXINS ALONG THE SECRETORY PATHWAY%REACTOME DATABASE ID RELEASE 66%215126 Transport of connexins along the secretory pathway Gja1 BICARBONATE TRANSPORTERS%REACTOME DATABASE ID RELEASE 66%10145616 Bicarbonate transporters Slc4a7 Ahcyl2 Slc4a9 Slc4a4 Slc4a3 Slc4a8 Slc4a2 Slc4a10 Slc4a5 Slc4a1 HEMOSTASIS%REACTOME DATABASE ID RELEASE 66%10145028 Hemostasis Selplg Kif21a Sele Kif21b Igll1 Kifc1 Cd244 Kif3c Racgap1 Kif22 Kif3b Cd84 Kif23 Glg1 Kif18b Kifap3 Kif11 Kif12 Gnaq Kif4a Kif6 Gna11 Kif1a Gna14 Kif1c Gna15 Nos3 Itga4 Serpine1 Kif27 Vpreb2 Itga6 Kif9 Vpreb1 Vpreb3 Kif13b Epcam Mertk Esam Cd48 Ptgir Fyn LOC497963 Cd9 Gnai3 Bsg Zfpm1 F11r Dock7 Akt1 Hdac1 Pdgfa Brpf3 Pdgfb Timp1 Nos1 Abcc4 A2m Tfpi F3 Itga3 G6b LOC288521 P2rx2 Kif20b P2rx3 Kif16b Ppil2 Kif26a P2rx5 P2rx6 Kif20a Kif26b Kif19 Plg P2rx4 Prkca Spn LOC100361537 Lyn Rhob Ceacam10 Syk Itgam Atp2b4 Sparc Atp2b2 Atp2b1 Mmp1 Actn2 Itgb2 App Atp2a2 Jam3 Atp2a3 Pde1b Ceacam1 Cd63 Prkcq Fgb Fgg Hgf Thbs1 Plaur Apob Thbd Fga F13b Procr Itgal LOC100909879 Itgax Qsox1 Actn1 Gng10 LOC685953 Pde9a Pde5a Cd36 Pde3a Tbxa2r Klkb1 L1cam Pafah2 Gna12 Vav2 Prkg2 Gna13 Vav1 Pde2a Cyct F12 Mrvi1 F11 Pde10a Serpina5 Pde11a C1qbp Atp1b3 Fn1 Atp1b2 LOC100909977 LOC100909700 Atp1b1 Csk Vav3 Rasgrp1 Rap1a Fcer1g Ptpn6 Itga2b Trpc3 Trpc7 Trpc6 Rad51c Raf1 Sh2b1 Ptpn1 Gata2 LOC100911167 Gata1 Cd47 Prkar1b Rasgrp2 Prkar1a Kif3a Gp1ba Gp9 Gp5 Gp1bb LOC100911551 F2rl3 Tgfb2 F2r Tgfb1 F2 F8 F7 Tgfb3 F9 F2rl2 Pik3r5 Pf4 Pik3r3 Pik3r6 Gnat3 Mapk1 Mapk14 Itpk1 Pla2g4a Trem1 Hist2h3c2 H3f3b Hdac2 Hdac1l LOC684841 Hist1h2ail1 LOC102549173 Hist1h3c Cd74 Hist1h3f Prkar2b Prkar2a LOC684819 Hist1h3a LOC684762 Arrb1 Tuba4a Arrb2 Lat Mag Lcp2 Stxbp3 Tex264 F13a1 Ola1 Klc1 Ly6g6f Ctsw Selp Serpina4 Slc7a8 Pcyox1l Tor4a Slc7a9 Islr Sri Cdc37l1 Chid1 Slc7a5 Fam3c Slc7a6 Lhfpl2 Slc7a7 Nhlrc2 Itih4 Mmrn1 Rarres2 Itih3 Slc7a10 Lefty2 Ecm1 Anxa5 Klc4 Tagln2 Gtpbp2 Kdm1a Timp3 Lefty1 Cenpe LOC100910414 Klc2 Plek Sccpdh Klc3 P2rx7 Phactr2 Mfn1 Slc8a3 Mfn2 LOC100911485 Kng1l1 A1bg Stx4 Plat Ptk2 Slc8a2 Slc8a1 LOC100909609 Aplp2 Figf Vegfc Vegfb Apoa1 Pik3cg Tln1 Crk Vwf Apbb1ip Bcar1 Slc7a11 Actn4 Vegfa Habp4 Pcdh7 Apool Apoh Wdr1 Srgn LOC100911881 Dock1 Lgals3bp Sytl4 Gpc1 LOC100912012 Fermt3 Cyb5r1 Maged2 Sod1 Aldoa Flna Clu Serping1 Rac2 Aldoart2 Kif2a Kif2c Kif2b Kif18a Kng1 Capzb Kif5b Kif5a Kng2 Serpinb8 Serpine2 S100a10 Serpinb2 Pdpk1 Cdc42 Pros1 Cd44 Dock5 Psap Dock3 Serpinb6b Rcor1 Dock9 Dock8 Dock6 Mical1 Lrrc16a Rac1 Akap1 Gata4 Slc16a3 Sdc2 Sdc3 Slc16a8 Sdc4 Slc16a1 Lamp2 Mif Cfd Serpind1 Adra2b Serpinb6 Dock11 Ehd3 Ehd2 Ehd1 Serpinc1 Hmg20b Phf21a Mafk Mafg Maff Cbx5 Nfe2 Akap10 Ak3 Anxa2 Rbsn Jmjd1c Zfpm2 Src Cd109 Rab27b Dgkk Dgki Cd177 Prkcb Ywhaz Dgkg Dgkd Dgke Dgka Dgkb Gnb3 Gnb5 Capza2 Gnb2 Gnb1 Gng13 Gng12 Gng11 Prkaca Prkacb Itpr1 Rapgef4 Dgkz Itpr3 Dgkq LOC100912034 Gnb4 Dgkh Gng4 Sh2b2 Gngt2 Serpina3m Gng5 Prkch Gngt1 Gng8 Gng3 Plau Vcl Gas6 Tf Mgll Abhd12 Daglb Abhd6 Dagla P2rx1 Pde3b Igf2 Igf1 RGD1565355 Gata3 Prkcd P2ry1 Kras Grb7 Dok2 Scg3 Pik3r1 Pik3r2 Stxbp2 LOC100360575 Sirpa LOC299277 P2ry12 Adra2a Fgr Gnai2 Adra2c Ppbp Lrp8 Pik3cb Tek Ptpn11 Rhoa Prcp Angpt1 Hras Nras Gnai1 Sos1 Rhog Angpt2 Angpt4 Shc1 Grb2 BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS%REACTOME%R-RNO-111453.1 BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members Bcl2l11 Bcl2 Bid Bmf Bad Pmaip1 POSITIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%R-RNO-5250913.1 Positive epigenetic regulation of rRNA expression Myo1c Kat2a RGD1565904 Polr1b Taf1d Polr2h Taf1c Cd3eap Polr2e Znrd1 Polr2f Polr1c Polr1a Polr2k Hist1h2bo Hist1h2bcl1 Hist2h3c2 LOC100912534 Hist1h2bk Actb H3f3b Sf3b1 Smarca5 Tbp LOC100910200 H2afx Hist1h4b LOC684841 Hist1h2bh LOC100912290 Hist1h2ail1 Hist1h4m LOC102549173 Mybbp1a LOC103690002 LOC100910152 LOC100912338 Hist1h3c H2afb3 Hist1h3f Ercc6 Hist2h4 LOC684819 Hist1h3a H2afj Hist2h2aa3 Hist1h2bq Hist2h2aa2 Ddx21 LOC100364835 Baz1b LOC684762 Twistnb Polr1e Hist1h2bg LOC680097 LOC684797 LOC100912418 Hist1h2ba Hist3h2bb Dek DEGRADATION OF CYSTEINE AND HOMOCYSTEINE%REACTOME DATABASE ID RELEASE 66%10145890 Degradation of cysteine and homocysteine Mpst Txn2 Suox Sqrdl Ethe1 Cdo1 Cth Tstd1 Tst Slc25a10 TRANSPORT OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 66%10144953 Transport of small molecules Trpc4ap Atp6v1g1 Atp6v1g2 Atp6v0a4 Atp6v1b2 Abca1 Atp6v0a2 Zdhhc8 Atp6v1h Atp6v1f Aqp11 Cygb Aqp4 Mip Aqp12a Car2 Aqp1 Car1 Slc22a1 Slc22a2 Slc6a3 Slc35c1 Nr1h3 Nedd8 Nr1h2 Bsg Slc5a1 Atp6v0d1 Atp6v1c2 Atp6v0d2 Myo5b Rab11fip2 Atp6v1a Slc2a2 Atp6v0e2 Atp6v0e1 Atp6v1g3 Atp6v1e1 Atp6v1e2 Atp6v1c1 Abcd2 Abcc4 Abcc2 A2m Abcc6 Aqp7 Abcd3 Abcb8 Abcb9 Derl3 Erlin2 Abcb10 Rnf5 Pex3 Abcb5 Abcb6 Abca4 Abca3 Abcf1 Abca2 Abcc10 Erlin1 Abca6 Abca5 Abcg4 Abcg1 Abcb1a Abca7 Abcg8 Abcg5 Scnn1b Camk2g Best1 Best3 Best2 Atp2b4 Scnn1g Tpcn2 Scnn1a Clcn4 Unc79 Atp2b2 Atp2b1 Slc9b1 Camk2d Clcn7 Cul1 Clcn6 Camk2a Clcn5 Ano10 Wwp1 Ano3 Clic2 Asic4 Asic5 Hbb-b1 Ano1 Trdn Atp7a Atp2a2 Atp7b Best4 Pln Clcnkb Asic3 Atp2a3 Lcat Lipg Pltp Slc9b2 Sar1b Apob Apoc2 Apoe Apoa2 Mttp Gng10 Slc5a11 Slc2a13 Slc17a3 Fxyd2 Sgk2 Fxyd3 Fxyd4 Sgk3 Atp10b Clcn1 LOC100912455 Wnk4 Atp11c Sln Ostm1 Wnk1 Wnk2 Wnk3 Psmb7 Psmb1 Atp9b Clcn2 Fxyd6 Atp10d Stom Fxyd7 Atp1b3 Atp1b2 Atp6v0a1 P4hb Clca4 Atp1b1 Psma5 Trpv4 Fkbp1b Trpv5 Atp8b3 Trpv6 Atp8b2 Atp8b1 Ano9 Ryr2 Ano4 Ano7 Atp2c2 Clca2 Atp2c1 Psma2 Stoml3 Mcoln2 Atp12a Mcoln3 Psmd2 Atp13a5 Trpv1 Atp13a4 Atp13a2 Trpc5 Trpm6 Ttyh1 Trpm3 Ttyh2 Psmc2 Trpm8 LOC100361584 Trpm5 Atp8a2 Atp1a4 Trpc3 Atp4b Psmd1 Trpc7 Atp4a Psmd7 Trpm1 Bsnd Trpc4 Mcoln1 Atp1a1 Atp1a2 Trpc6 Psmd3 Trpv3 Atp13a1 Atp1a3 Psmd6 Trpa1 Slc6a11 Slc6a13 Slc6a1 Slc6a12 Raf1 Abcd1 Furin Slc22a5 Derl1 Prkar1b Prkar1a Bmp1 Fbxl5 Skp1 Slc21a4 Apobr Vldlr Apoc1 LOC100910181 Apoc4 Kcnj11 Abcc9 Prkar2b Prkar2a Os9 Erlec1 Slc5a8 Hba1 Slc25a22 Slc17a5 Rab11a Slc17a6 Slc17a7 Slc17a8 LOC100911440 Slc25a18 LOC287167 Slc5a5 Sel1l Slc7a3 Slc7a2 Slc7a1 Slco4a1 Slc4a7 Slc4a9 Slc2a9 Slc11a2 Slc7a8 Slc7a9 Sri Fgf21 Slc50a1 Slc7a5 Slc7a6 Slc7a7 Angptl4 Slc6a2 LOC100361444 Heph Lmf1 Slc14a1 Lmf2 Slc18a1 Slc7a10 Slc30a10 Slc4a4 Slc4a3 Slc22a15 Slc6a7 Slc46a1 Slc4a8 Slc6a9 Slc2a12 Slc2a10 Slc6a6 Slc6a5 Slc12a4 Slc39a2 Slc12a2 Slc39a3 Slc12a1 Slc39a4 Slc39a6 Slc8b1 Slc38a3 Slc38a2 Slc38a5 Slc38a4 Slc22a6 Slc8a3 Slc12a5 Slc22a3 Slc3a1 LOC100911874 RGD1559971 Cand1 Slc25a29 Slc43a2 Slc43a1 Slc22a7 Vegp2 Slc39a7 Slc39a8 Slc12a6 Slc12a7 Slc47a1 Slc8a2 Slc8a1 RGD1304770 Slc5a6 Pdzd11 Slc1a3 Slc1a5 Slc1a4 Slc15a1 Slc1a7 Slc1a6 Lcn1 Slc1a1 Slc5a4 Slc5a2 Scarb1 Slc9a1 Cubn Amn Hdlbp Apoa1 Vps25 Slc24a4 Slc24a2 Slc20a2 Slc10a6 Ahcyl2 Slc35d1 Slco3a1 Slc45a3 Slc2a6 Slc2a4 Lcn12 Slc5a10 Slc4a2 Slc4a5 Slc4a1 Slc7a11 Slc13a4 Slc41a1 Slc41a2 Slc40a1 Slc24a5 Slc13a1 Slc13a2 Slc26a2 Slc13a3 Slc26a1 Slco1c1 Lcn9 Slc5a9 Slc5a7 Slc20a1 Slc4a10 Cyb5r1 Slc15a3 Slc27a1 Pmpcb Slco1a1 Pmpca Slc35b2 MGC94335 Afg3l2 Rhag Micu3 Slc44a4 Stoml2 Micu2 Slco1a4 Slc35b3 Slco1a2 LOC100910779 Micu1 Slc44a5 Yme1l1 Spg7 Slc44a3 Phb2 Rhcg Slco1b2 LOC688708 Slc25a10 Slc30a5 Nipal1 Tusc3 Slc16a10 Slc30a6 Mrs2 Slc30a8 Nipal4 Pqlc2 Slc27a6 Gpihbp1 Slc39a14 Ankh G6pc Lrrc8e Slc9a4 Lrrc8c Slc9a5 Lrrc8b Slco2b1 Lrrc8a Slc31a1 Azgp1 Slc26a7 Dmtn Slc26a9 Pip Slc26a6 Slc30a1 Slc27a4 Slc26a3 Slc36a2 Slc33a1 Slc34a1 Slc35a2 Slc16a2 Slc34a3 Slc32a1 Slc38a1 Add1 Slc6a15 Nipa1 Slc6a14 Add2 Atp6ap1 Slc6a19 Ctns Slc6a18 Nipa2 Slc35b4 Add3 Slc36a4 Nipal2 Slc6a20 Nipal3 Slc36a1 Slco1a6 Slc35d2 Slco2a1 Apod Slc2a1 Slc9a2 LOC100362065 Slc9a9 RGD1561777 Ccdc109b Slc9a3 Mcu Slc9a6 Cp Slc9a8 Slc9a7 Atp6v1d Psmc6 Eif2s3 Psmb10 Ftl1 Psmb8 Psmb9 Psmb4 Psmb11 Psmb5 Psmf1 Psmb6 Magt1 Psmd4 Psmb2 Psmd5 Psmd8 Psmd9 Psmb3 Psma8 Psmd11 Psmd12 Slc16a3 Eif2s1 Slc16a7 Eif2s2 Psmd13 Slc16a8 Psmd14 Slc16a1 Ap2a2 Slc28a2 Slc28a1 Slc28a3 Slc29a3 Atp8a1 Slc29a2 Slc29a4 LOC100911721 Slc29a1 LOC691960 Psmc3 Trpm2 Atp6v0c Slco4c1 RGD1561661 Cltc Clta Ap2s1 Ap2a1 Ap2m1 Pcsk9 Gnb3 Gnb5 Gnb2 Gnb1 Gng13 Gng12 Gng11 Prkaca Prkacb Ano6 LOC100912034 Gnb4 Gng4 Gngt2 Gng5 Gngt1 Gng8 Gng3 Slc11a1 Vcp Ldlr Tfrc Tf Avp Hmox1 Ireb2 Aco1 Ftmt Tfr2 Hfe Abcg2 Slc44a2 Abcg3l3 Abcg3l1 Steap2 Cybrd1 Cyb5r2 Cyb5rl Runx1 Tcirg1 Hmox2 LOC100360087 Npc1 Slc35a1 Nceh1 Lipa Mylip Mb Soat1 Soat2 Sgk1 Atp11a Psmc5 Psma1 Slc2a8 Psma4 Psmc1 Lpl Psma3 Psmc4 Psma6 Psme1 Psme2 Pcsk6 Ldlrap1 Pcsk5 INTERLEUKIN-1 PROCESSING%REACTOME%R-RNO-448706.1 Interleukin-1 processing Nfkb2 Nfkb1 Il1b Il18 Casp1 Il1a Rela FC EPSILON RECEPTOR (FCERI) SIGNALING%REACTOME DATABASE ID RELEASE 66%10145167 Fc epsilon receptor (FCERI) signaling Psmc6 Psmb10 Psmb8 Psmb9 Psmb4 Psmb11 Psmb5 Psmf1 Psmb6 Rac1 Psmd4 Psmb2 Psmd5 Psmd8 Psmd9 Psmb3 Psma8 Psmd11 Psmd12 Psmd13 Psmd14 Psmc3 Ube2n Bcl10 Ube2d1 Jun Skp1 Ppp3r1 Nfkb1 Mapk9 Mapk8 Fos Fbxw11 Chuk Btrc Mapk1 LOC100362142 Tab2 Tab3 Lyn LOC100912618 Ube2v1 Ikbkb Syk Mapk10 Map2k7 Map2k4 LOC100912399 Map3k1 Traf6 Cul1 Cdc34 Tab1 Rela Map3k7 Lat2 Prkcq Pak2 Nfkbia LOC100910771 Pak1 Kras G6pc Pik3r1 Pik3r2 Psmb7 Psmb1 Vav2 Vav1 Psma5 Vav3 Pdpk1 Psma2 RGD1560225 Psmc5 Pik3cb Psma1 Psmd2 Ppp3ca Psma4 Nfatc2 Tec Psmc1 Psma3 Txk Psmc4 Psma6 Psmc2 Lat Plcg1 Psme1 Psmd1 Hras Psme2 Psmd7 Nras Sos1 Nfatc3 Lcp2 Psmd3 Shc1 Psmd6 Grb2 Itk SEROTONIN RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145563 Serotonin receptors Htr7 Htr5a Htr4 Htr2c Htr2a Htr1d Htr1f Htr1a Htr6 Htr1b Htr2b REVERSAL OF ALKYLATION DAMAGE BY DNA DIOXYGENASES%REACTOME DATABASE ID RELEASE 66%10146230 Reversal of alkylation damage by DNA dioxygenases Fto Alkbh5 PROTEIN-PROTEIN INTERACTIONS AT SYNAPSES%REACTOME%R-RNO-6794362.1 Protein-protein interactions at synapses Dlgap2 Grin2d Dlgap3 Grin2b Dlgap4 Grin1 Epb4.1l5 Grm1 Lrrtm2 Lrrtm3 Lrrtm4 LRRTM1 Dlg1 Dlg2 Dlg3 Dlgap1 Lrrc4b Ppfia1 Ppfia2 Ppfia3 Lrfn2 Ppfia4 Lrfn3 Lrfn1 Lrfn4 Ptprd Slitrk6 Slitrk5 Slitrk3 Slitrk2 Slitrk1 Ppfibp1 Il1rap Ppfibp2 Ptprf Epb4.1 Nrxn2 Shank1 Shank2 Nlgn1 Homer3 Nlgn2 Nlgn3 Homer2 Homer1 Epb41l2 Epb41l3 Il1rapl1 Gria3 Gria4 Flot1 Flot2 Rtn3 Dbnl Ntrk3 Dlg4 MET PROMOTES CELL MOTILITY%REACTOME DATABASE ID RELEASE 66%10146247 MET promotes cell motility Gab1 Src Crk Rap1a Itga3 Dock7 Rac1 Hgf Lama4 Lamc1 Lamc2 Lamb1 Crkl Ptk2 Lamb2 Lama1 Tns4 Rapgef1 Lamb3 Grb2 LOC100911248 MRNA EDITING: C TO U CONVERSION%REACTOME%R-RNO-72200.1 mRNA Editing: C to U Conversion Apobec1 Apobec2 A1cf Apobec4 ECM PROTEOGLYCANS%REACTOME%R-RNO-3000178.1 ECM proteoglycans Ncan Agrn Itgb6 Sparc Dcn Comp LOC102550316 Tnn Serpine1 Vtn Itga8 Itga7 Acan Tnr Vcan Bcan Col9a1 Col9a2 Col9a3 Dspp Dmp1 LOC100910284 Hapln1 Matn4 Itga2b Matn1 Dag1 Itgax P38MAPK EVENTS%REACTOME DATABASE ID RELEASE 66%10145201 p38MAPK events Ralgds Kras Hras Nras Mapk14 Mapkapk3 Mapk11 Mapkapk2 INNATE IMMUNE SYSTEM%REACTOME%R-RNO-168249.1 Innate Immune System Myo1c Ppie Actb Pld4 Ube2n Atox1 Tlr7 Tlr8 Irak4 Myo10 Eea1 Nlrp4 Map2k7 Dtx4 Ripk2 Tbk1 Map2k6 Ddx41 Ager Nlrp4a Dusp3 Irf3 Map2k4 Trim21 Map3k8 Trim32 Dusp4 Peli3 Nfkbib LOC100912399 Peli2 Map3k1 Traf6 Cul1 Vrk3 Commd9 Rps6ka2 Rps6ka1 Pdxk App Cd53 Atg7 Rps6ka3 Xrcc6 Rps6ka5 Bpi Tirap Hbb-b1 LOC100912585 Xrcc5 Tab1 Dusp7 Dusp6 Rela Atf1 Atf2 Map3k7 Peli1 Irak2 Cd59 Np4 Ctsa Ptprc Cyfip1 Serpinb3a Cd63 Pnp Sdcbp RGD1304587 Cct2 Apaf1 LOC100909857 Ddost LOC498300 Vamp8 Defa7 Gdi2 Anpep Plaur Nfkbia Serpinb12 LOC100910771 Cct8 Defa5 Cst3 Dnajc13 Nckap1l Serpinb10 LOC100909879 Ilf2 Qsox1 Mpo Fcgr3a C1s LOC685953 C1r Slc2a5 Cd36 Masp2 C1qb Ctsc Rock1 Colec10 Rap2b C4a Syngr1 C1qa Tmem179b C4b Svip Serpinb1b Ctsz Mlec LOC100909666 Arg1 Gzmm Frk LOC102549354 Serpinb1a C2 Cstb Psmb7 Psmb1 Vapa Lrrc7 Prdx4 Gmfg C5ar1 Nme2 LOC687609 Dsn1 Lrmp Rap2c Grn Stom Dsp Cab39 Cd14 LOC100909700 Atp6v0a1 Ltf Psma5 Slpi Padi2 Plekho2 Rap1a Fcer1g Tollip Gsn Pkp1 Chi3l1 Psma2 Pglyrp1 Snap29 Psmd2 Commd3 Idh1 Bst1 Ptpn6 Psmc2 Fgl2 Tnfaip6 Psmd1 Psmd7 Iqgap1 Prdx6 Tspan14 Psmd3 Psmd6 Colec11 Lbp Ptpn4 Jun Ppp2cb Ppp2ca Skp1 Ppp2r1a Nfkb2 Nfkb1 Mapk9 Mapk8 Fos S100b Mapk7 Dhx9 Fbxw11 Chuk Ppp2r1b Ecsit Mapkapk3 Btrc Mapkapk2 Mapk1 Nkiras1 LOC100362142 Nod1 Nod2 Nkiras2 Creb1 Tab2 Tab3 LOC100912618 Ube2v1 Ikbkb Mapk14 Myd88 Tnip2 Mapk11 Mapk10 Hsp90b1 RGD1560225 Ppp3ca Nfatc2 Tec Txk Lat Plcg1 Nfatc3 Lcp2 Itk Cnpy3 Unc93b1 Tlr3 Ddx3x Plac8 RGD1563818 Cotl1 Cmtm6 RT1-A2 Lpcat1 RT1-A1 Ggh Clec5a B2m LOC100125364 Glipr1 Rnaset2 Gpr84 RGD1561778 Ist1 Cpped1 Cand1 A1bg Clec4d Pdzd11 Crk Atp6v1d Cda Lamp1 Ftl1 Psap RatNP-3b Svs1 Fuca2 Serpinb6b Igf2r Lrg1 RGD1306474 Magt1 Rac1 Acly Cap1 Pdap1 Bpifb2 Doxl2 Doxl1 Cpne3 Rnase17 Rab27a Psmd11 Psmd12 Fabp5 Dynlt1 Psmd13 Psmd14 Tmem30a Lamp2 Unc13d Mif Ap2a2 Crisp3 Cfp S100a11 Aga Cfd RT1-M3-1 Serpinb3 Atp8a1 Kcmf1 Aldh3b1 Ndufc2 Serpinb6 Aprt Faf2 Cpne1 Psmc3 Diaph1 Trpm2 LOC100364500 Defa11 Fcnb Defa10 RT1-S3 Cant1 Bcl10 Tmem173 Cxcr2 Atp6v0c RGD1564463 Anxa2 Rbsn Mgst1 Retn RT1-CE2 Dpp7 Nit2 Src RT1-CE3 RT1-CE4 RT1-CE7 RT1-CE5 Slco4c1 Hsp90ab1 RGD1561661 Rab3a Copb1 Cat Cd177 RT1-CE10 Hebp2 Rab7a Ptges2 Ptafr Tubb5 Creg1 Pigr Mettl7a Alox5 Kcnab2 Ppp3r1 Pygb Rab4b Bcl2 Ticam2 Mme Neu1 Lta4h Ms4a3 Cxcl2 Cxcl1 Epx S100a8 Cd68 Rab5b Cxcl3 Rab5c Chit1 Ampd3 Capza2 Slc27a2 Dgat1 Rab6a LOC683761 LOC100364956 Atp6ap2 Tmem63a Ptprn2 Nhlrc3 Naprt1 Ano6 Pa2g4 Gm2a Dbnl Fcgr2b LOC103693683 Atad3a Serpina3m Rab9b Fcgr2a Trappc1 Tlr2 Plau Slc11a1 Kpnb1 Chrnb4 Fpr1 Arl8a Pld1 Ostf1 Ear1 Vcl Prg3 Erp44 Stk10 Sptan1 Vcp Prg2 Rab18 Cd300lb Siglec15 Ghdc LOC100910990 Slpil3 Rab10 Cd300e Rab14 Slpil2 Cdc34 Vnn1 Rab24 Actr10 Nbeal2 Lamtor3 RT1-A Arsa Tmbim1 Tnfaip3 Dok3 Dync1h1 P2rx1 Acaa1a Acaa1b Lamtor2 Lamtor1 Apeh Ypel5 Dync1li1 Slc44a2 LOC103692716 Qpct RGD1565355 Cybb Cyba LOC361635 Actr1b RT1-M2 Hmha1 Lgals3 RT1-M5 RT1-M4 Nfam1 Ubr4 Crispld2 Pycard Crebbp Stk11ip Rab3d Rbm12 Galns Gca C3ar1 Prkcd Armc8 Olfm4 Fcar Kras Gstp1 Asah1 Pik3r1 Mnda Pik3r2 Bri3 Ptx3 Srp14 Tcirg1 Hmox2 Ptprj Jup Mospd2 Impdh1 Ddx58 Impdh2 Ap1m1 Nfasc Rnase3 LOC100360575 Rnase2 Enpp4 Sirpa Tyrobp LOC100360087 Cdk13 LOC299277 Golga7 Hvcn1 Stbd1 Dsg1 Txndc5 Dnajc5 Csnk2b Actr2 Fgr Alad Gla Dnajc3 Tnfrsf1b Arhgap9 RGD1559482 C3 RT1-M6-1 Lair1 Ppbp Atp11a Vat1 Pik3cb Uba3 Aoc1 RT1-M6-2 Map3k14 Agpat2 Ptpn11 Relb Rhoa Eef2 Arpc5 Gsdmd Prcp Hras Cyb5r3 Nras Rhof Sos1 Rhog Ckap4 Tbc1d10c Degs1 Shc1 Grb2 Tom1 RGD1308751 Nos3 Mavs Atp6v1g1 Bpifa2 Atp6v1g2 Rnase6 Bpifa1 Atp6v0a4 Atp6v1b2 Fyn Atp6v0a2 Atp6v1h Atp6v1f LOC497963 Stat6 Bpifb4 Pglyrp3b Pglyrp3 Bpifb6 Pglyrp4 Pglyrp2 Itln1 Eppin Bpifa2f Chga Bpifa5 Reg3g Elane Adam8 Ube2d1 LOC103690254 Try10 LOC100365995 Atp6v0d1 Atp6v1c2 Atp6v0d2 Timp2 Atp6v1a Atp6v0e2 Atp6v0e1 Atp6v1g3 Atp6v1e1 Atp6v1e2 Atp6v1c1 Nos1 MGC114246 Capn1 Testin Lyn Yes1 Hck Ceacam10 Syk Mmp8 Itgam Mmp9 Try4 Itgb2 Vtn Atp7a Ceacam1 Prkcq Tlr4 Prss2 Ikbke Tank Traf3 LOC100364523 Apob Itgal Itgax Prss1 Ctsd Ctsb Trem2 Ctsg Ctsl Ctsm Ctsj RGD1564657 Vav2 Ctsk Vav1 Ctsq Ctsr LOC100909977 LOC102554637 Vav3 Cts8 Cts7 RGD1564827 Icam2 Pla2g6 Raf1 Psen1 Ncstn LOC364561 Pin1 LOC683849 Cd47 Cts8l1 Ttr Il1b F2 Mre11a Cpb2 Txn1 Lgmn Lat2 Trem1 Ube2m Myo9b Abi1 Abi2 Potef Panx1 Myh9 Nck1 Sugt1 Txnip Mefv Pstpip1 P2rx7 Arpc1b LOC100909750 Ncf1 Ncf4 Ptk2 Actg1 Cyfip2 Nckap1 Defb26 Defb28 Ccr6 Hexb Defb30 Defb18 LOC100909609 Defb36 Defb14 Pld2 Defb12 Defb29 Defb49 Defb25 Defb43 Defb44 Tax1bp1 Art1 Defb13 Defb41 Defb1 Defb22 Defb23 Defb20 Defb21 Fcgr1a Cd247 Pkm Nlrp3 Pgam1 Glb1 Dock1 Elmo2 Klrc2 Manba Aldoa Gyg1 Aldoc Cpn1 Cpn2 Cr2 Clu C5ar2 Cd46 Serping1 Brk1 C6 Pfkl Pgm2 Cfhr1 Cd19 Pgm1 C8g Baiap2 RGD1564614 Cd81 C8a B4galt1 C8b Limk1 Nf2 Pak2 Pak3 Cfh Pak1 Wasl Aldoart2 Abl1 Wasf1 Arpc4 G6pc Agl Arpc3 Pla2g2a Gpi Nckipsd LOC100361457 Cd209b Cd209e Clec4m Actr3 Was Mapk13 Cd209a Mapk12 Pik3c3 Arsb Pik3r4 Pdpk1 Dhx36 Cdc42 LOC100911597 Dera Gusb Hpse Man2b1 Wipf1 Wipf2 Wipf3 Cd44 Psmc6 Psmb10 Gaa Psmb8 Psmb9 Psmb4 Psmb11 Pygl Psmb5 Psmf1 Psmb6 Psmd4 Psmb2 Psmd5 Psmd8 Psmd9 Psmb3 Psma8 Ppapdc1a Pld3 Ppapdc1b Prkaca Prkacb Tlr9 Cd4 Birc3 Birc2 Aim2 Cyld Tlr6 Tlr10 Casp4 Casp1 Casp2 Nlrp1a Casp8 Casp9 Psmc5 Cd3g Psma1 Psma4 Psmc1 Psma3 Psmc4 Psma6 Psme1 Psme2 TRANSMISSION ACROSS ELECTRICAL SYNAPSES%REACTOME DATABASE ID RELEASE 66%10145508 Transmission across Electrical Synapses Gja10 Panx1 Gjd2 Gjc1 EPHA-MEDIATED GROWTH CONE COLLAPSE%REACTOME DATABASE ID RELEASE 66%10146028 EPHA-mediated growth cone collapse Src Fyn Rhoa LOC100912512 Lyn Yes1 Ngef IRF3 MEDIATED ACTIVATION OF TYPE 1 IFN%REACTOME%R-RNO-1606341.1 IRF3 mediated activation of type 1 IFN Irf3 HDL REMODELING%REACTOME DATABASE ID RELEASE 66%10145453 HDL remodeling Apoa1 Apoc2 Apoe Abcg1 Lcat Lipg Pltp SIGNALING BY GPCR%REACTOME DATABASE ID RELEASE 66%10144870 Signaling by GPCR Plcb1 Plcb3 Ffar1 Gnaq Gna11 Gna14 Gna15 Plcb4 Gnai3 Akt1 Gnao1 Chrm4 Gnat2 Gnaz Rhob Rhoc Rps6ka2 Rps6ka1 App Rps6ka3 LOC100912585 Rock1 C5ar1 Tshb Gnal Gnat3 Grp Ppp2cb Ffar4 Ppp2ca Ppp2r1a Mapk7 Ppp2r1b Mapk1 Adora3 Creb1 Adora2a Adora2b LOC100911796 LOC100363178 Adora1 LOC100365814 Lrp1 Gpr39 Olr663 Olr660 Olr561 Olr1024 Olr560 LOC100910009 Olr158 Cnga1 Olr557 LOC100910335 Gucy2f Pde6b Olr164 Rcvrn Olr659 Olr160 Gucy2d Pde6a Olr657 Rgs9 Olr662 RGD1560341 Olr664 Olr1868 Olr1199 Gpr27 Olr653 LOC100910402 Olr651 Olr650 Olr294 LOC100911909 Olr544 Olr1197 Olr1196 Olr1195 Olr1194 Olr1198 LOC100910409 Olr1128 LOC100911893 LOC100910928 Olr323 Olr119 Olr1126 LOC100912097 Olr1125 Olr420 Olr217 Olr1121 Olr1122 Olr1129 Olr322 Olr214 Gpr84 Olr215 Olr414 Guca1b Ppef1 Olr1512 Kng1l1 Metap2 Olr1513 Metap1 Olr416 Olr556 Gnat1 Nmt1 Gpr150 Olr1511 Guca1a Cngb1 Olr413 Olr1517 Rgs9bp Olr319 Fnta Olr120 Nmt2 Olr321 Sag Olr1514 Grk4 LOC100911380 Grk1 Fntb Olr417 Olr418 Pde6g LOC100910041 Olr259 Olr1163 Olr1166 LOC684208 Olr127 Olr530 Olr126 Olr931 Olr674 Olr129 Olr532 Olr1174 Olr670 Gpr45 Olr675 Olr892 Olr247 Olr1156 Olr190 Olr194 Olr267 LOC500460 Olr192 Olr262 Olr1064 Olr896 Olr263 LOC100910049 Olr698 Olr799 LOC103693566 Olr922 Olr684 Olr1186 LOC100910120 Olr536 Olr1185 Olr143 Olr535 Olr140 Olr142 Olr148 LOC100910648 Olr1016 Olr149 Olr951 Gpr25 LOC100910224 Olr666 Olr1179 Olr522 Olr130 Olr527 Olr526 LOC100910637 Olr132 LOC100910010 Olr529 Olr528 Olr139 Olr137 Olr686 Olr1877 LOC100910559 Olr186 Olr189 Olr1081 Olr1147 Olr188 Olr584 Olr1082 Olr281 Olr382 Olr384 Olr1086 Olr1087 Olr587 Olr581 Olr282 Olr776 Olr582 Olr777 Olr583 Olr283 Olr962 Gpr15 Olr964 Olr285 Olr286 Olr1135 Olr1132 Olr172 LOC100910051 Olr1130 Olr170 Olr198 Olr588 Olr199 Olr1155 Olr597 Olr1057 Olr196 LOC100911805 Grk6 Olr252 Olr1052 Olr598 Olr695 Olr251 Olr250 Olr697 LOC100910999 Olr590 Grk5 LOC100910445 Olr1143 Olr180 Olr690 Olr1144 Olr783 Olr379 Olr1142 LOC100910162 Olr782 Gpr176 LOC100911839 Olr184 Olr845 LOC100910274 Olr847 Olr848 Olr1391 Gpihbp1 Olr852 Olr1496 LOC686792 LOC100912204 Olr1096 LOC100365798 RGD1562066 Olr844 Olr841 Olr744 Olr745 LOC100909686 Olr878 LOC100910597 Olr1376 Penk Olr850 Olr851 LOC100909578 LOC100909683 LOC100910294 Kng1 LOC687097 LOC100909884 LOC100909885 Olr1374 Olr1372 Olr1373 Olr1370 Kng2 Olr1071 Olr569 Olr174 Olr175 Olr774 Olr176 Htr4 Olr1274 Olr1076 LOC100910876 Olr575 Olr1075 Olr373 Olr1275 Olr1070 Olr1137 Htr7 Olr375 Olr377 Olr378 Olr372 Olr1079 Olr374 Olr1073 Olr854 Olr853 Olr279 LOC100911035 Olr765 Olr278 Olr376 Htr6 LOC100910256 Npff Npffr2 Olr834 Olr641 RGD1560028 LOC100909438 Psap Hcrt LOC100909796 Npffr1 Gpr83 Qrfp LOC690821 LOC100912217 LOC100909783 Olr601 Olr602 Olr604 Olr709 Olr609 Olr607 Olr608 LOC687088 Olfr873 Olr806 LOC686677 Olr702 Olr808 Olr705 Olr704 Olr807 Olr519 Oxgr1 Olr614 Olr718 Olr811 Ccr1 Olr514 Ccr1l1 Olr515 Ptgdr2 Olr611 Sucnr1 Olr610 Olr819 Olr716 Olr713 Olr816 Olr717 Olr714 Olr813 Olr812 Olr1382 Olr1381 Olr1384 Olr1383 Olr711 LOC100912327 Olr818 Olr712 Olr724 Olr1380 Reep6 LOC684683 Olr720 Olr722 LOC686660 Olr1385 Hcrtr1 Olr1378 Qrfpr Reep1 Cxcr2 Reep5 Hcrtr2 Olr729 Reep4 Reep3 Reep2 Olr725 Ptafr Gpr31 Cxcl2 Rgr Cxcl1 Gpr18 Gpr55 Gpsm3 Htr5a Gpsm2 Cxcl3 Gpsm1 Cnr2 Ccl4 Opn3 Cnr1 Htr1d Htr1f Htr1a Htr1b Hrh4 Ptger3 Gpr183 Mtnr1a Opn5 Pcp2 Hcar1 Hcar2 LOC687065 Drd5 Drd1 LOC684539 Drd4 Drd2 Olr820 Olr821 Olr823 Fpr1 Mgll Abhd12 Daglb Abhd6 Dagla C3ar1 Prkcd Kras Pik3r1 Pik3r2 Adra2a Gnai2 Adra2c Rbp4 C3 Lrp10 Rbp2 Ppbp Tex12 Rbp1 Lrp8 Apom Lrp12 Rhoa Lpl Bco1 Rdh11 Lrat Hras Nras Bco2 Sos1 Gnai1 Grb2 Olr1442 Olr1443 Olr1548 Olr80 Olr1440 Olr1547 Ppp1ca Pde4a Egfr Hbegf Pde4d Pde4c Ppp1r1b Ghrl Cdk5 Olr1436 Ptgir Olr1569 Olr1567 Olr1421 Olr1568 Olr1565 Olr1566 Olr1538 LOC100912374 Olr1539 Olr1437 Olr1439 Olr1433 Olr1434 Olr1435 LOC103690304 Olr83 LOC100912370 Olr1533 Olr1432 Olr1535 Olr1537 Olr1536 Olr81 Olr1449 Olr1542 Olr1541 Olr1540 Olr1445 LOC103693022 LOC100912463 Pnlip Clps Abca4 Prkca Oprl1 Tas2r144 Ccl21 Grm3 Casr Prokr2 Mc3r Grm1 Ccr5 Grm6 Gal Tas2r113 Ccr4 Grm2 Ccr3 Grm8 Gpr37 Ccl27 Cckar Tas2r114 Gper1 Tas2r110 Ccl20 Uts2r Prokr1 Ccl25 NMS Gprc6a Tas2r124 Xcr1 Tas2r125 Cxcl16 Tas2r126 Pdyn Prlhr Tas2r121 Ccr10 Tas2r103 Gpr37l1 Tas2r104 Ccl19 Tas2r123 Ccr7 Tas2r116 Ccr8 Tas2r140 Cxcr3 Tas2r120 Tas2r102 Cxcl10 Ccr9 Tas2r145 Cxcl11 Tas2r119 Ece2 Tas2r118 Ece1 Tas2r117 Xk Pde1b Sstr5 Brs3 Tas2r107 Tas2r108 Npbwr1 Tas2r105 Pyy Pnoc Tas2r106 Tas2r129 Ccl5 Npy2r Tas2r109 Mc4r Prkcq Tas2r136 Prok2 Tas2r137 Tas1r1 Oprm1 Prok1 Tas2r135 Mchr1 Sstr1 Tas2r13 Aplnr Tas2r130 Tas1r3 Sstr4 Tas2r139 Sstr2 Cck Npy1r Apln Tacr3 Apob Tacr2 Bdkrb1 Apoc2 Apoe Bdkrb2 Rln3 Apoa2 Npb Ppy Trh Ccl1 Npw Mc2r Npy Gng10 Nps Arhgef6 Arhgef5 Pde3a Arhgef39 Arhgef7 Arhgef37 Arhgef38 Arhgef33 Prex1 Adra1a Tbxa2r Itsn1 Arhgef2 LOC102556447 Arhgef4 Arhgef3 Plekhg5 Sstr3 Arhgef19 Arhgef18 Plekhg2 Kalrn Adra1d Plxnb1 LOC100912512 Gna12 Vav2 Gna13 Pde2a Vav1 Arhgef11 Cyct Akap13 Arhgef16 Pde10a Arhgef15 Pde11a Gphb5 Net1 Gnrhr Ect2 Gpha2 Arhgef26 Fgd2 Gnrh1 Mcf2l Tiam1 Fshr Tiam2 Vav3 Tshr Fgd3 Sos2 Ngef Cxcr5 Uts2b Npy5r Nmur2 Cxcr6 Oprd1 Trpc3 Trpc7 Lhcgr LOC100909513 Trpc6 LOC100360745 Olr1600 Olr1605 Olr1405 Olr1601 Olr1407 Olr1404 Olr1406 LOC100910837 Olr1368 Olr1369 Olr226 LOC100911348 Olr229 Olr227 Olr1602 LOC684170 LOC103692138 Olr1504 Lhb Olr233 Olr428 Olr232 Olr427 Olr1505 Olr234 LOC100911377 Olr1400 LOC100911376 Olr231 Ptgdr Olr425 Olr1501 Olr230 Olr208 Olr1202 Awat2 Adcy8 Olr244 LOC103693685 Adcy9 Olr1519 Adcy5 Olr203 Adcy4 Olr411 Adcy7 Olr209 Adcy6 Prkar1b Olr1007 Prkar1a Olr1006 LOC100911223 Ttr Olr237 Olr434 Olr1306 Olr442 Olr441 Olr113 Olr210 Olr1520 Olr114 Olr1523 Olr218 Olr1522 Olr1521 F2rl3 Olr206 F2r Olr1118 Olr204 F2 Olr205 RGD1564865 LOC100911398 Ptger2 Olr1115 Cga F2rl2 Olr1117 Hebp1 Uts2 Pde7a Pik3r5 Fpr-rs6 Ntsr2 Olr1734 Olr1340 Trhr Olr485 Nmu Fpr-rs3 Pf4 Olr486 Olr16 Mc5r Fpr2 Ntsr1 Olr1735 Fpr3 Pik3r3 LOC100911043 Pmch Anxa1 Pik3r6 Olr1737 Rxfp1 Olr14 Rxfp2 Olr1736 Kel Fpr-rs4 Insl3 Olr488 Tac3 Olr484 Pde7b Kiss1 Olr1730 Rxfp3 LOC100912515 Tac1 Edn2 Olr1627 Olr491 Ednra Ednrb Olr1626 Edn3 Olr490 Grpr Olr1621 Cx3cr1 LOC100912408 Edn1 Olr1625 F2rl1 Olr1624 Olr200 Sst Olr339 Ackr4 Olr1345 Ackr3 Olr338 Nmb Olr1343 Xcl1 Cxcl9 Olr202 Olr1344 Cxcl6 Olr1341 Cx3cl1 Olr1356 Taar9 LOC100912605 LOC100911849 Hrh2 Fshb LOC100910199 Taar6 Agt Olr346 Taar5 Taar2 Olr1214 Olr450 Olr499 Olr496 LOC100912505 Olr493 Olr1606 Akt3 Olr1607 Olr1749 Agtr2 Prlh Olr1608 Olr1362 Galr1 Ccrl2 Olr459 Nts Olr458 Olr1361 Oprk1 Olr1366 Olr1364 Olr360 Olr462 Olr1611 Olr1610 Olr1358 Olr1612 Olr20 Olr24 Olr23 Olr1456 LOC100912431 Olr1597 Olr1593 Olr1592 Olr1450 Olr1452 Olr1598 Olr1454 LOC100909966 LOC100365887 LOC100912159 Olr1654 LOC103693822 Olr30 Olr32 Pla2g4a Olr34 Olr331 Olr332 Olr1643 Olr334 Olr330 Olr1642 Olr1644 Olr1645 Olr473 Olr470 Olr1744 Olr1641 Olr1743 Olr1746 Olr472 Olr1640 Pde8b Olr477 Olr475 Pde8a LOC100911479 Olr1235 Olr1738 LOC103690286 Olr1231 Olr329 Or7e24 LOC103690280 Olr326 Olr325 Olr1339 Olr1639 Olr13 Olr12 Olr1637 Olr1638 Olr340 Olr341 LOC102555599 Olr1635 Gabbr1 Olr1630 Olr1631 Gabbr2 Olr1632 Olr1633 Olr1423 Olr1560 Olr63 LOC100912684 Olr1424 Olr1564 Olr1425 Olr1422 Olr1558 Olr1559 LOC684179 Olr1555 Ptgdrl Olr67 Olr68 Olr69 Olr1416 Cxcl12 Olr70 Olr1418 Olr1417 Olr1551 Adcy3 Prkar2b Olr1557 Prkar2a Olr1553 LOC686967 Olr77 LOC100909611 Olr1693 Rtp4 Olr74 Cxcr4 RGD1562400 Olr78 Olr75 Olr1583 Olr1589 Olr1488 LOC100912420 Olr1582 LOC100909993 Rtp3 Rtp2 Olr1475 Olr1470 LOC687110 Olr1576 Olr49 Olr46 Olr1588 Olr48 Arrb1 Olr1467 Olr1468 Olr1469 Olr50 Arrb2 Olr51 Olr59 Olr1671 Olr1471 Olr1667 Olr29 LOC100909831 Adrbk1 Olr27 Olr25 Cyp4v3 Olr1462 LOC100912540 LOC100911586 Rock2 Stra6 Rdh10 Rdh16 LOC100365958 LOC100362350 Akr1c12l1 Cmklr1 Gpr35 Akr1c19 Akr1c13 Akr1c14 Akr1c12 Ccr6 Pomc Apoa1 Oxtr Oxt Rpe65 LOC100909648 Avpr1b Dhrs9 Pik3cg Avpr1a Myo7a Sdr9c7 Hsd17b6 Gpc6 Gpc4 Gpc2 Gpc1 Opn1sw Dhrs3 Rlbp1 Akr1b7 Akr1b8 Opn1mw Ghrh Ramp3 Vipr2 Sct C5ar2 Gip Gipr Akr1c2 Pth1r Iapp Crhr2 Akr1c3 Gcgr Adgre1 Crhr1 Glp2r Pth2 Ramp2 Ghrhr Akr1c1 Agrn Pdpk1 Sdc2 Sdc3 Sdc4 Adra2b Adrb3 Pth Sctr Adm Crhbp Calcb Vip Calca Ramp1 Htr2c Htr2a Adcyap1r1 Ucn Dgkk Adcyap1 Dgki Ucn2 Pth2r Adm2 Htr2b Crh Lpar5 S1pr1 S1pr5 S1pr4 S1pr3 Lpar1 Lpar3 Lpar2 S1pr2 Ccl9 Ccl6 Dgkg Gpr4 Dgkd Dgke Dgka Dgkb Gpr132 Gnb3 Gpr143 Gnb5 Rgs3 Lppr1 Gnb2 Opn4 Rgs19 Gnb1 Lppr4 Rgs2 Lppr5 Gng13 Rgs18 Lppr2 Gng12 Lppr3 Hrh1 Gng11 Prkaca Chrm1 Prkacb Chrm5 Ghsr Itpr1 Arhgef25 Dgkz LOC100909523 Itpr3 LOC100912034 Dgkq Gnb4 Dgkh Cysltr2 Glp1r Camk4 Gcg Cysltr1 Gng4 Gpr65 Gngt2 Gpr68 Ptgfr Gng5 Gngt1 Prkch Ptger1 Gng8 Gng3 Chrm3 Agtr1b Agtr1a Chrm2 Ltb4r Ffar2 Ffar3 Ltb4r2 Avp Pde3b Akt2 P2ry6 Lpar6 P2ry4 P2ry1 Gpr17 Lpar4 P2ry12 P2ry2 P2ry10 P2ry13 Cckbr Gast Adrb2 Tacr1 ELASTIC FIBRE FORMATION%REACTOME%R-RNO-1566948.1 Elastic fibre formation Itgb6 Itgb8 LOC102553715 Vtn Itga8 Fbn1 Efemp1 Furin Efemp2 Fbln2 LOC100911714 Fbln1 Fbln5 Lox Mfap2 Gdf5 Ltbp3 Ltbp2 Mfap5 Ltbp4 Mfap4 Eln Ltbp1 Bmp2 Loxl4 Bmp7 Bmp4 Mfap3 Tgfb2 Loxl1 Tgfb1 Tgfb3 FGFR4 LIGAND BINDING AND ACTIVATION%REACTOME%R-RNO-190322.1 FGFR4 ligand binding and activation Fgf23 Fgf4 Fgf1 Fgf16 Fgf17 Fgf6 Fgf19 Fgf9 Fgf2 Fgf8 Fgf20 Fgfr4 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION%REACTOME%R-RNO-400508.1 Incretin synthesis, secretion, and inactivation Gnat3 Dpp4 Lep Grp Gip Gpr119 Ffar4 Gnb3 Gcg Ffar1 Gng13 METALLOTHIONEINS BIND METALS%REACTOME%R-RNO-5661231.1 Metallothioneins bind metals Mt3 INSULIN PROCESSING%REACTOME DATABASE ID RELEASE 66%10145456 Insulin processing Slc30a5 Exoc8 Exoc7 Slc30a6 Slc30a8 Ero1l Ins1 Ero1lb Ins2 Exoc3 Exoc2 Exoc1 Exoc6 Exoc5 ANCHORING FIBRIL FORMATION%REACTOME%R-RNO-2214320.1 Anchoring fibril formation Bmp1 Lamc2 Tll2 Col7a1 Tll1 Lamb3 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF UNSATURATED FATTY ACIDS%REACTOME DATABASE ID RELEASE 66%10144949 mitochondrial fatty acid beta-oxidation of unsaturated fatty acids Decr1 Eci1 Acadm SCAVENGING BY CLASS A RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145956 Scavenging by Class A Receptors Hsp90b1 Calr Colec12 Scgb3a2 Apob Apoa1 Apoe Marco Msr1 CLATHRIN DERIVED VESICLE BUDDING%REACTOME%R-RNO-421837.1 Clathrin derived vesicle budding Ftl1 LOC100909548 Igf2r Necap1 Clvs1 Picalm Chmp2a Tgoln2 Hip1r Tfrc App Vamp2 Dnm2 Ap1m2 Gbf1 Snx5 Snx9 Snx2 Acbd3 Sort1 Cpd Dnase2 Clint1 Yipf6 Ap4s1 Ap1b1 Vamp8 Tpd52 Sh3gl2 Stx4 Ocrl Ap4e1 Golgb1 Ap4b1 Ap1g2 RGD1561661 Ctsz Napa Tpd52l1 Cltc Cltb Snapin Ap1m1 Clta Ap3b1 LOC100360087 Bloc1s3 Pum1 Txndc5 Ap4m1 Bloc1s4 Bloc1s1 Bloc1s6 Rab5c Arrb1 M6pr Ap1s3 Ap1s1 Ap1s2 Pik3c2a Gak Vamp7 SCAVENGING BY CLASS H RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145959 Scavenging by Class H Receptors Stab2 Apob Sparc POLB-DEPENDENT LONG PATCH BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 66%10146093 POLB-Dependent Long Patch Base Excision Repair Parp2 Fen1 Parp1 LOC100911727 Adprhl2 Parg Apex1 Polb Lig1 MACROAUTOPHAGY%REACTOME%R-RNO-1632852.1 Macroautophagy Chmp2b Chmp2a Uvrag Atg16l1 Wipi1 Wipi2 Ulk1 Mtmr14 Atg7 Atg13 Atg14 Atg10 Ambra1 Atg3 RragB Lamtor3 Prkab1 Chmp4b Prkab2 Chmp4c Chmp4bl1 Lamtor2 Lamtor1 Dynll2 Atg12 Map1lc3a Gabarap Chmp7 Mtmr3 Chmp6 Chmp3 Mtor Rheb Prkag3 Gabarapl2 Pik3c3 Rptor Lamtor4 Tsc1 Lamtor5 Mlst8 Pik3r4 Prkaa1 Tsc2 Rraga Prkaa2 Rragc Becn1 Rb1cc1 Atg101 Rragd Atg4c Slc38a9 Atg4d Gabarapl1 Atg9a Atg9b Wdr45b GOLGI ASSOCIATED VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 66%10145614 Golgi Associated Vesicle Biogenesis Ftl1 Necap1 Igf2r Picalm Tgoln2 Hip1r Tfrc Dnm2 Vamp2 Ap1m2 Snx5 Snx9 Snx2 Acbd3 Sort1 Cpd Clint1 Yipf6 Ap1b1 Vamp8 Tpd52 Sh3gl2 Ocrl Ap4e1 Golgb1 Ap4b1 RGD1561661 Napa Tpd52l1 Cltc Snapin Ap1m1 Clta Ap3b1 LOC100360087 Bloc1s3 Txndc5 Pum1 Bloc1s4 Bloc1s1 Rab5c Bloc1s6 Arrb1 Ap1s3 Ap1s1 Ap1s2 Pik3c2a Gak Vamp7 HEDGEHOG LIGAND BIOGENESIS%REACTOME%R-RNO-5358346.1 Hedgehog ligand biogenesis Psmc6 Psmb10 Psmb8 Psmb9 Psmb4 Psmb11 Psmb5 Psmf1 Psmb6 Psmd4 Vcp Psmb2 Psmd5 Psmd8 Psmd9 Psmb3 Psma8 Psmd11 Psmd12 Psmd13 Psmd14 Disp2 Psmc3 G6pc Dhh Shh Psmb7 Psmb1 Ihh Os9 Erlec1 P4hb Psma5 Psma2 Psmc5 Psmd2 Psma1 Psma4 Psmc1 Psma3 Psmc4 Psmc2 Psma6 Psme1 Psmd1 Psme2 Psmd7 Scube2 Psmd3 Sel1l Psmd6 SIGNALING BY NTRK3 (TRKC)%REACTOME DATABASE ID RELEASE 66%10146326 Signaling by NTRK3 (TRKC) Src Plcg1 Ntrk3 Ntf3 SIGNALING BY NTRK2 (TRKB)%REACTOME DATABASE ID RELEASE 66%10146316 Signaling by NTRK2 (TRKB) Gab1 Crk Dock7 Rac1 Hgf Ntf4 Ntrk2 Bdnf Plcg1 Crkl Sos1 Frs2 LOC100911248 Grb2 NEGATIVE REGULATION OF NOTCH4 SIGNALING%REACTOME DATABASE ID RELEASE 66%10146331 Negative regulation of NOTCH4 signaling Notch4 Akt1 ERBB2 ACTIVATES PTK6 SIGNALING%REACTOME%R-RNO-8847993.1 ERBB2 Activates PTK6 Signaling Ereg Nrg1 Btc LOC102552659 Erbb3 Erbb2 Nrg3 Egfr Hbegf Nrg4 Ptk6 Erbb4 Nrg2 WNT MEDIATED ACTIVATION OF DVL%REACTOME DATABASE ID RELEASE 66%10145393 WNT mediated activation of DVL Csnk2a2 Csnk2b Dvl2 Pip5k1b Dvl3 Csnk1e Csnk2a1 Dvl1 LOC100361515 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY%REACTOME%R-RNO-2173795.1 Downregulation of SMAD2 3:SMAD4 transcriptional activity Smad3 Smad2 Parp1 Usp9x Ube2d1 Skil Ncor2 Hdac1l Hdac1 Tgif2 Tgif1 Trim33 Ube2d3 REGULATION OF IGF ACTIVITY BY IGFBP%REACTOME%R-RNO-381426.1 Regulation of IGF Activity by IGFBP Hrc Mbtps1 Fuca2 Shisa5 Mfi2 Bpifb2 Vwa1 LOC100911764 Sdc2 Igfbp6 Amtn Cyr61 Igfbp2 Pappa2 Klk1c12 Csf1 Serpind1 Klk1c10 Wfs1 Chgb Igfbp1 Igfbp5 Mgat4a Igfbp4 Enam Kng1l1 LOC100909521 Afp Serpinc1 Bmp4 Mfge8 F2 Igfbp7 Notum LOC304903 Calu Bmp15 Aplp2 Mepe Gzmf Apoa1 Gzmn Timp1 LOC100910060 Pcsk9 Dmp1 Amelx LOC691670 Prkcsh Pnpla2 Fam20c Plg Tmem132a Mxra8 Lgals1 Nucb1 Fam20a Mmp1 Mmp2 Ambn Tgoln2 Gas6 Fgf23 Apol2 Hsp90b1 App Msln RGD1309808 Lamc1 Tf Apol11a Apol3 Vgf LOC100910885 Apol9a Fbn1 Fstl1 Stc2 Igf2 Fstl3 Igf1 Prss23 Fgg Apob Chrdl1 Apoe Fga Apoa2 Cst3 Lamb1 Lamb2 Qsox1 Scg2 Spp1 C4a Scg3 Ktn1 C4b Il6 Sparcl1 LOC100909666 LOC102549354 Men1 Ctsg Penk LOC100911615 Kng1 Rcn1 Eva1a Kng2 Fn1 Vcan P4hb Cdh2 Pappa Igfals Dnajc3 C3 Ltbp1 Klk10 Klk1c6 Klk13 Klk1c8 Ckap4 Serpina10 Klk1c9 Cp Klk1c2 Klk1c3 EUKARYOTIC TRANSLATION TERMINATION%REACTOME DATABASE ID RELEASE 66%10146146 Eukaryotic Translation Termination N6amt1 Trmt112 Apeh Gspt1 Etf1 Gspt2 ACTIVATED NTRK3 SIGNALS THROUGH PLCG1%REACTOME DATABASE ID RELEASE 66%10146327 Activated NTRK3 signals through PLCG1 Plcg1 Ntrk3 Ntf3 THE NLRP1 INFLAMMASOME%REACTOME DATABASE ID RELEASE 66%10145732 The NLRP1 inflammasome Bcl2 Nlrp1a SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP)%REACTOME%R-RNO-400511.1 Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) Dpp4 Gip Gpr119 Ffar1 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER%REACTOME%R-RNO-76061.1 RNA Polymerase III Transcription Initiation From Type 1 Promoter Bdp1 Polr3d Polr3c Polr3a Polr3e RGD1565904 Polr3b Polr3h Polr2h Polr3k Polr2e Polr2f Polr1c Polr3g Polr2k Polr3f Gtf3c6 Gtf3c5 Gtf3c1 LOC100912534 Gtf3c3 Gtf3c4 Polr3gl Brf1 Gtf3a Tbp TRANSCRIPTIONAL REGULATION BY MECP2%REACTOME%R-RNO-8986944.1 Transcriptional Regulation by MECP2 Hdac1 Hipk2 Hdac2 Sin3a Hdac1l MITOCHONDRIAL TRANSLATION%REACTOME%R-RNO-5368287.1 Mitochondrial translation Mrps11 Mrps12 Mrps16 Mrps14 Mrps18b Mrps18c Mrps10 Mrps18a Mrps33 Mrps34 Mrps21 Mrps35 Mrps17 Mrps15 Mrps31 Mrps30 Mrps24 Mrps23 Mrps22 mrpl9 Mrps28 Mrps27 Mrps26 Mrps25 Mrpl4 Mrpl3 Mrpl2 Oxa1l Mtrf1l LOC367117 Mrrf Mrpl1 Mrpl13 Mrpl10 Mrpl18 Mrpl19 Mrps9 Mrps2 Mrps5 Mrps7 Mrpl36 Mrpl37 Mrpl20 Mrpl14 Mrpl16 Mrpl12 Mrpl15 Mrpl41 Mrpl35 Mrpl40 Mrpl33 Mrpl34 Mrpl38 Mrpl32 Mrpl27 Mrpl23 Mrpl28 Mrpl30 Mrpl21 Mrpl54 Mrpl46 Mrpl55 Mrpl44 Mrpl43 Mrpl47 Mrpl49 Mrpl53 Mrpl48 Mrpl52 Mrpl51 Mrpl50 mrpl11 mrpl24 Chchd1 Dap3 Eral1 Gadd45gip1 Ict1 Ptcd3 Gfm2 Gfm1 PROTEIN LOCALIZATION%REACTOME DATABASE ID RELEASE 66%10146283 Protein localization Phyh Ide Nudt7 Hmgcl Coq2 Acot4 Acot8 Acox1 Ehhadh Dhrs4 Eci3 Gstk1 Hsd17b4 Mlycd Acot2 Acot5 Acaa1a Acaa1b Pex2 Agps Hao1 LOC497963 Hao2 Pex5 Ddo Baat Ndufb8 Pipox Gnpat Agxt Paox Amacr Pitrm1 Hscb Ldhd Otc Usp9x Ube2d1 LOC100911156 Cat Ube2d3 Crot Pex14 Pex10 Pex13 Pex12 Acox3 Acox2 Slc27a2 Pex26 Idh1 Lonp2 Tysnd1 Pex1 Crat Zfand6 Pex6 Pex7 LOC103690024 Mpv17 Ech1 Hacl1 Ephx2 Atp5b CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX%REACTOME%R-RNO-68689.1 CDC6 association with the ORC:origin complex Mcm8 E2f1 E2f3 Orc4 Orc5 Orc6 Orc1 Orc2 E2f2 Orc3 Cdc6 RESOLUTION OF D-LOOP STRUCTURES%REACTOME%R-RNO-5693537.1 Resolution of D-Loop Structures Bard1 Wrn Rbbp8 Rmi1 Rmi2 Rad51c LOC100911267 Rad51d Spidr Rad51 Eme2 Brca2 Eme1 Rtel1 Rad50 Atm Xrcc3 Brca1 Blm Slx4 Mus81 Slx1b Slc25a16 Palb2 Gen1 Xrcc2 Nbn Mre11a SPHINGOLIPID DE NOVO BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 66%10145630 Sphingolipid de novo biosynthesis Osbp Csnk1g2 Sgpl1 Cers1 Acer2 Acer1 Acer3 Cers2 Vapa Kdsr Degs2 Gdf1 Sptlc3 Sptlc1 Prkd3 Sptlc2 Fa2h Ppap2a Prkd1 Prkd2 Ppap2b Sgpp2 Sgms1 Vapb Sptssb Ormdl1 Sptssa Aldh3a2 Aldh3b1 Sphk2 Ormdl2 Col4a3bp LOC498300 Ppap2c Cers4 Cers3 Samd8 Cers6 RGD1564463 Degs1 CLEARANCE OF DOPAMINE%REACTOME%R-RNO-379401.1 Clearance of dopamine Maoa Comt Slc6a3 Lrtomt GABA SYNTHESIS%REACTOME DATABASE ID RELEASE 66%10145746 GABA synthesis Gad2 Gad1 SUMOYLATION OF TRANSCRIPTION COFACTORS%REACTOME DATABASE ID RELEASE 66%10145995 SUMOylation of transcription cofactors Ing2 Mbd1 Safb Park7 Pias3 Pias1 LOC100911274 Hipk2 Pias2 Phc1 Phc2 Scmh1 Cbx4 Cbx2 Cbx8 Sumo1 Bmi1 Daxx Rnf2 Sin3a Mkl1 Ring1 Sumo3 Phc3 Zfp131 Pcgf2 Ube2i Ddx5 Uhrf2 Nrip1 Topors Ncoa1 SIGNALING BY WNT%REACTOME DATABASE ID RELEASE 66%10145342 Signaling by WNT Plcb1 Pde6b Nlk Plcb3 Pde6a Rbx1 Csnk2a2 Leo1 Csnk2a1 Wnt9b Wnt9a Vps26a Wls LOC100361515 Lrp5 Lrp6 Wnt3 Rnf43 Daam1 Rspo1 Wnt7a Wnt2b Lgr4 Wnt7b Lgr6 Vps29 Lgr5 Wnt16 Rspo4 Vps35 Sox9 Wnt3a Rspo2 Wnt10a Usp8 Rspo3 Wnt6 Pde6g Pard6a Akt1 Hdac1 Gnao1 Gnat2 Prkca Cul1 Camk2a Map3k7 Pip5k1b LOC100909468 Xpo1 LOC100910771 Rac2 Gng10 Ppp2r5e G6pc Men1 Psmb7 Psmb1 Ppp2r5c Ppp2r5a Ppp2r5b Psma5 Dvl1 Psma2 Psmd2 Dvl2 Dvl3 Pfn1 Psmc2 Psmd1 Psmd7 Psmd3 Psmd6 Psmc6 Psmb10 Psmb8 Psmb9 Psmb4 Psmb11 Psmb5 Psmf1 Psmb6 Rac1 Psmd4 Psmb2 Psmd5 Psmd8 Psmd9 Psmb3 Psma8 Psmd11 Psmd12 Psmd13 Psmd14 Ap2a2 Psmc3 Rbbp5 Wnt5b Wnt5a Prickle1 Fzd1 Cltc Cltb Fzd3 Clta Fzd2 Fzd4 Ppp2cb Fzd7 Ppp2ca Fzd6 Skp1 Ppp2r1a Prkcb Ywhaz Ap2s1 Wnt1 Ppp3r1 Wnt11 Wnt4 Xiap Ap2a1 Tnks Ror1 Ror2 Ap2m1 Gnb3 Gnb5 Ppp2r1b Gnb2 Gnb1 Btrc Gng13 Gng12 Gng11 LOC100912034 Gnb4 Gng4 Gngt2 Gng5 Gngt1 Gng8 Gng3 Ctbp2 Apc Dkk1 Kremen2 Sost Chd8 Hist1h2bo Hist1h2bcl1 Hist2h3c2 Hist1h2bk Smurf1 H3f3b Smarca4 Hdac1l Tle3 Tnks2 Crebbp LOC100910717 Akt2 Peg12 LOC100910200 Amer1 Cdc73 H2afx Csnk1a1 Hist1h4b Frat2 LOC684841 Hist1h2bh LOC100912290 Hist1h2ail1 Hist1h4m LOC102549173 LOC103690002 Tert LOC100910152 LOC100912338 Hist1h3c H2afb3 Hist1h3f Hist2h4 LOC684819 Hist1h3a H2afj Hist2h2aa3 Hist1h2bq Hist2h2aa2 Ash2l LOC100364835 LOC684762 Sox2 Hecw1 Csnk2b Dact1 Wnt8a Sox7 Sox6 Sry Sox17 Ctnnbip1 Ryk Wnt8b Dkk2 Dkk4 Cby1 Sox13 RGD1560225 Psmc5 Pygo2 Psma1 Ppp3ca Psma4 Arrb2 Psmc1 Rhoa Psma3 Csnk1e Psmc4 Psma6 Psme1 Hist1h2bg Tcf7 Psme2 Lef1 Tcf7l1 LOC680097 Bcl9l LOC684797 Tle4 LOC100912418 Tle1 Hist1h2ba Tle2 Hist3h2bb Pygo1 ESTROGEN BIOSYNTHESIS%REACTOME%R-RNO-193144.1 Estrogen biosynthesis Akr1b7 Akr1b8 Hsd17b14 Hsd17b1 Hsd17b2 Cyp19a1 Hsd17b11 SUMOYLATION OF CHROMATIN ORGANIZATION PROTEINS%REACTOME%R-RNO-4551638.1 SUMOylation of chromatin organization proteins Nup93 Nup43 Nup98 Nup133 Nup107 Pias1 Aaas Nup210 Npap60 Nup35 Nup37 Nupl2 Nupl1 Pias2 Scmh1 Cbx4 Cbx2 Cbx8 Sumo1 Bmi1 Hdac2 Rnf2 Ring1 Sumo3 Hdac1l Phc3 Pcgf2 Hdac4 Nup205 Ube2i Ranbp2 Satb2 Satb1 Hist1h4b LOC100912290 Nup155 Hist1h4m Hdac1 LOC100911274 Nup88 Hist2h4 Nup85 Phc1 Nup153 Phc2 Tpr Rae1 Nup54 Pom121 LOC680097 Nup62 LOC100912418 CLEAVAGE OF THE DAMAGED PURINE%REACTOME DATABASE ID RELEASE 66%10144974 Cleavage of the damaged purine Mpg Ogg1 Mutyh DEPOLYMERISATION OF THE NUCLEAR LAMINA%REACTOME DATABASE ID RELEASE 66%10146031 Depolymerisation of the Nuclear Lamina Cnep1r1 Cdk1 Lmnb1 Lemd3 Lmna Lemd2 Ctdnep1 Lpin2 Prkca Lpin3 Prkcb Lpin1 Tmpo EPIGENETIC REGULATION OF GENE EXPRESSION%REACTOME DATABASE ID RELEASE 66%10145445 Epigenetic regulation of gene expression Myo1c Kat2a RGD1565904 Polr1b Taf1d Taf1c Polr2h Cd3eap Polr2e Znrd1 Polr2f Polr1c Polr1a Polr2k Tdg Hist1h2bo Hist1h2bcl1 Hist2h3c2 LOC100912534 Hist1h2bk Actb H3f3b Sf3b1 Smarca5 Suv39h1l1 Tbp Eed LOC100910200 H2afx Hist1h4b Phf19 LOC684841 Hist1h2bh Dnmt1 LOC100912290 Rbbp7 Hist1h2ail1 Hist1h4m Mybbp1a LOC102549173 LOC103690002 LOC100910152 Dnmt3a LOC100912338 Hist1h3c H2afb3 Hist1h3f Ercc6 Dnmt3b Hist2h4 LOC684819 Hist1h3a H2afj Rrp8 Hist2h2aa3 Suv39h1 Hist1h2bq Hist2h2aa2 Mtf2 Ddx21 Phf1 LOC100364835 Baz1b LOC684762 Twistnb Polr1e Jarid2 Hist1h2bg Mbd2 Ezh2 LOC680097 LOC684797 LOC100912418 Hist1h2ba Dek Hist3h2bb Aebp2 REACTIONS SPECIFIC TO THE HYBRID N-GLYCAN SYNTHESIS PATHWAY%REACTOME%R-RNO-975574.1 Reactions specific to the hybrid N-glycan synthesis pathway Mgat3 RHO GTPASES ACTIVATE PAKS%REACTOME%R-RNO-5627123.1 RHO GTPases activate PAKs Flna Myh14 Myh11 Ppp1r12a LOC102551071 Ppp1cb Rac1 Cdc42 LOC100911597 Limk1 Nf2 Myh9 Pak2 Pak3 Pak1 Mylk DEGRADATION OF DVL%REACTOME DATABASE ID RELEASE 66%10145877 Degradation of DVL Psmc6 Psmb10 G6pc Psmb8 Psmb9 Psmb4 Psmb11 Psmb5 Psmf1 Psmb6 Psmd4 Psmb2 Rbx1 Psmd5 Psmd8 Psmb7 Psmd9 Psmb1 Psmb3 Psma8 Psmd11 Psmd12 Psmd13 Psmd14 Hecw1 Dact1 Psma5 Dvl1 LOC100361515 Psma2 Psmc5 Psmc3 Psmd2 Psma1 Dvl2 Psma4 Dvl3 Psmc1 Psma3 Psmc4 Psmc2 Psma6 Psme1 Psmd1 Psme2 Psmd7 Psmd3 Psmd6 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS%REACTOME DATABASE ID RELEASE 66%10145193 TGF-beta receptor signaling activates SMADs Smad3 Smad2 Nedd8 Fkbp1a Strap Tgfbr1 Ube2m Cbl Mtmr4 Tgfbr2 Zfyve9 Pmepa1 Tgfb1 Bambi Furin Stub1 PYRUVATE METABOLISM%REACTOME%R-RNO-70268.1 Pyruvate metabolism Bsg Glo1 Pdpr Rxra Pdhb Pdk3 Pdk4 Pdk1 Pdk2 LOC100365902 Pdha2 Pdha1 Pdhx Ppard Slc16a3 Pdha1l1 Slc16a8 Slc16a1 Ldhc Ldha Gstz1 Vdac1 Ldhb Pdp1 Hagh Dlat Me1 Dld PLATELET ACTIVATION, SIGNALING AND AGGREGATION%REACTOME DATABASE ID RELEASE 66%10145027 Platelet activation, signaling and aggregation Stxbp3 Tex264 F13a1 Ola1 Ly6g6f Ctsw Selp Serpina4 Pcyox1l Tor4a Islr Cdc37l1 Gnaq Chid1 Gna11 Fam3c Lhfpl2 Gna14 Nhlrc2 Gna15 Itih4 Mmrn1 Rarres2 Itih3 Lefty2 Serpine1 Ecm1 Anxa5 Tagln2 Gtpbp2 Timp3 Lefty1 LOC100910414 Plek Sccpdh Phactr2 Fyn Cd9 Kng1l1 A1bg Stx4 Ptk2 Gnai3 Aplp2 Figf Vegfc Vegfb Akt1 Pdgfa Brpf3 Apoa1 Pdgfb Timp1 Pik3cg Abcc4 A2m Tln1 Crk Vwf Apbb1ip Bcar1 G6b Actn4 Vegfa Habp4 Pcdh7 Apool Apoh Wdr1 Plg Srgn Prkca LOC100911881 Lyn Lgals3bp Sytl4 LOC100912012 Fermt3 Rhob Syk Cyb5r1 Maged2 Sparc Sod1 Actn2 Aldoa App Flna Clu Cd63 Serping1 Prkcq Fgb Fgg Thbs1 Hgf Fga Rac2 Aldoart2 Qsox1 Actn1 Gng10 LOC685953 Cd36 Tbxa2r Gna12 Kng1 Vav2 Gna13 Vav1 Kng2 Fn1 Csk Vav3 Rasgrp1 Rap1a Fcer1g Pdpk1 Cdc42 Pros1 Ptpn6 Itga2b Trpc3 Trpc7 Trpc6 Psap Raf1 Ptpn1 Rac1 Lamp2 Cfd Rasgrp2 Adra2b Gp1ba Gp9 Gp5 Gp1bb LOC100911551 F2rl3 Tgfb2 F2r Tgfb1 F8 F2 Tgfb3 F2rl2 Pik3r5 Src Pf4 Pik3r3 Cd109 Pik3r6 Rab27b Dgkk Dgki Gnat3 Prkcb Ywhaz Dgkg Dgkd Dgke Dgka Dgkb Gnb3 Gnb5 Gnb2 Gnb1 Gng13 Gng12 Mapk1 Gng11 Itpr1 Rapgef4 Dgkz Itpr3 Dgkq LOC100912034 Gnb4 Dgkh Gng4 Mapk14 Gngt2 Serpina3m Gng5 Gngt1 Prkch Gng8 Gng3 Vcl Gas6 Pla2g4a Tf Mgll Abhd12 Daglb Abhd6 Dagla Igf2 Igf1 RGD1565355 Prkcd P2ry1 Scg3 Pik3r1 Pik3r2 Stxbp2 LOC299277 P2ry12 Adra2a Gnai2 Adra2c Ppbp Arrb1 Pik3cb Tuba4a Ptpn11 Arrb2 Rhoa Lat Gnai1 Rhog Sos1 Lcp2 Shc1 Grb2 LOSS OF NLP FROM MITOTIC CENTROSOMES%REACTOME%R-RNO-380259.1 Loss of Nlp from mitotic centrosomes Dync1i2 Cep57 LOC691918 Haus3 Ninl Akap9 Ccp110 Dync1h1 Pafah1b1 LOC103692716 Dctn1 Cntrl Dctn2 Cep76 Pcm1 Cep78 LOC100911033 Cep164 Dctn3 Cep41 Ofd1 Sdccag8 Tubb5 Prkar2b Cenpj Ywhag Ppp2r1a Plk4 Ywhae LOC100912076 Tubg2 Haus2 Haus1 Haus5 Alms1 Clasp1 Haus4 Odf2 Tubb4a Cdk1 Nek2l1 Ssna1 Mapre1 Tubg1 Cep63 Prkaca Csnk1d Cep131 Tuba4a Cep250 Cep135 Csnk1e Ckap5 Cdk5rap2 Pcnt Nek2 Cep72 Sfi1 Cep70 Actr1a Nedd1 CAM PATHWAY%REACTOME DATABASE ID RELEASE 66%10144992 CaM pathway Prkcd Pde1b Adcy8 Adcy9 Adcy5 Adcy4 Adcy7 Adcy6 Prkar1b Prkar1a Prkaca Prkacb Adcy3 Prkar2b Prkca Prkar2a Camk4 Adrbk1 SIGNALING BY SCF-KIT%REACTOME DATABASE ID RELEASE 66%10145420 Signaling by SCF-KIT Stat5a Ptpru Src Kras Grb7 Stat1 Pik3r3 Pik3r1 Mmp9 Pik3r2 Stat3 Rac1 Grap Fer Vav1 Cma1 Fyn Cbl Grb10 Ptpn11 Tec Fes Ptpn6 Prkca Lyn Hras Yes1 Nras Sh2b2 Sos1 Kit Kitlg Grb2 TIGHT JUNCTION INTERACTIONS%REACTOME%R-RNO-420029.1 Tight junction interactions Prkci Crb3 Pard6a Pard3 Pard6g Mpp5 F11r Inadl Pard6b NUCLEOTIDE METABOLISM%REACTOME DATABASE ID RELEASE 66%10144816 Nucleotide metabolism Cda Adprm Nudt9 Nt5c2 Nudt5 Nudt16 Adal Nudt18 LOC688828 Uck1 Entpd2 Tymp Dck Entpd6 Entpd3 Entpd4 Entpd1 Entpd7 Entpd5 Entpd8 Txnrd1 Gsr Tyms Dtymk LOC305806 Nme3 Nudt13 Nme1 Ak5 Pnp Ak4 Ak6 Ak8 Rrm2b Dut Ctps2 LOC100909857 Ctps1 Aprt Uckl1 Tk2 Hdhd1 Uck2 Upp1 Upp2 Tk1 Glrx Nudt15 Rrm2 Rrm1 Nudt1 Dctd LOC100360124 LOC100359853 Guk1 Nt5c1a Nt5c Nt5c3a Nt5e Upb1 Nt5m Impdh1 Impdh2 Gmpr2 Ampd1 Gmpr Nme2 Xdh Dpys Dguok Hprt1 Ada Ampd2 Ampd3 Txn1 Pfas Cad Ppat LOC100912917 Adss Gmps Nt5c1b Lhpp Atic Gda Gart Adsl Itpa Samhd1 Adssl1 Umps Dhodh Paics Dnph1 INHIBITION OF ADENYLATE CYCLASE PATHWAY%REACTOME%R-RNO-997269.1 Inhibition of adenylate cyclase pathway Gnat3 Adcy8 Adcy9 Gnai3 Adcy5 Adcy3 Adcy4 Gnai2 Adcy7 Adcy6 Gnal Gnai1 RNA POLYMERASE II TRANSCRIBES SNRNA GENES%REACTOME DATABASE ID RELEASE 66%10146187 RNA polymerase II transcribes snRNA genes Ints4 Ints5 Ints6 Ints7 Ints9 Phax Ints1 Ints3 Ints2 Pcf11 RGD1565904 Ice2 Zc3h8 Polr2g Polr2h Polr2e Polr2f Polr2j Polr2k Polr2d Polr2i Polr2b Polr2c Ssu72 Polr2a Ice1 Vwa9 Gtf2f1 LOC100912534 Gtf2f2 Ell Gtf2a1 Pou2f1 Nabp1 Nabp2 Tbp Ccnt2 Rprd1a Gtf2e1 Sp1 Gtf2e2 Snapc3 Snapc4 Cdk9 Taf11 Taf13 Taf9 Ccnk Ell3 LOC100911822 Supt5h Ell2 Rpap2 Cpsf3l Rprd1b Taf6 Taf5 Taf8 Ncbp2 Ncbp1 Supt4h1 Cdk7 Gtf2b Asun RGD1562299 Snapc5 Snapc2 MRNA DECAY BY 3' TO 5' EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 66%10145639 mRNA decay by 3' to 5' exoribonuclease Wdr61 Hbs1l Dcps Exosc9 Exosc2 Exosc1 Nt5c3b Exosc4 Ttc37 Exosc7 Exosc5 Exosc3 AMINE-DERIVED HORMONES%REACTOME%R-RNO-209776.1 Amine-derived hormones Aanat Slc5a5 Asmt Tph1 Tpo Pnmt Tph2 Iyd Duox2 Ddc Duox1 Tshb Dbh Cga Th PROGRESSIVE TRIMMING OF ALPHA-1,2-LINKED MANNOSE RESIDUES FROM MAN9 8 7GLCNAC2 TO PRODUCE MAN5GLCNAC2%REACTOME%R-RNO-964827.1 Progressive trimming of alpha-1,2-linked mannose residues from Man9 8 7GlcNAc2 to produce Man5GlcNAc2 Man1c1 Man1a2 Man1a1 AMINO ACID AND DERIVATIVE METABOLISM%REACTOME%R-RNO-71291.1 Amino acid and derivative metabolism Smox Sat1 RGD1564480 Slc7a5 Slc6a7 Oca2 Slc45a2 Tyrp1 Tyr LOC308670 Paox Mccc2 Fah Mccc1 Tat Gcsh LOC100911156 Sds Hrsp12 Pcbd1 Sdsl Aanat Hpd Phykpl Asmt Tph1 Tph2 Hgd Il4i1 Pah Asrgl1 Agmat Qdpr Enoph1 Mtap Mri1 Adi1 Pnmt Ddc Dbh Th Nmral1 Ass1 Nags Cps1 Slc25a2 Pipox Aldh7a1 Gcdh Aadat Dlst Slc25a10 Hykk Ogdh G6pc Serinc4 Psph Rimklb Serinc2 Gpt Serinc3 Srr Aspa Arg1 Nat8l Serinc1 Naalad2 Pdhb Folh1 Pycrl Psmb7 Aldh18a1 Psmb1 Oat Asns Pycr2 LOC100365902 Pycr1 Pdha2 Pdha1 Pdhx Pdha1l1 Slc36a4 Gstz1 Psma5 Shmt1 Dlat Psma2 Psmd2 Psat1 Phgdh Psmc2 Psmd1 Psmd7 Psmd3 Dld Psmd6 Nqo1 Slc6a11 Ndufab1 Psmc6 Oaz3 Slc6a12 Psmb10 Sardh Oaz1 Dmgdh Oaz2 Psmb8 LOC683884 Chdh Psmb9 Psmb4 Psmb11 Psmb5 Psmf1 Psmb6 Psmd4 Psmb2 Psmd5 Psmd8 Got1 Psmd9 Psmb3 Azin1 Psma8 Psmd11 Psmd12 Txnrd1 Psmd13 Psmd14 Got2 Acat1 Psmc3 LOC100910122 Tpo Iyd Duox2 Mat1a Duox1 Tshb Cga Ahcy Mtrr Mtr Ckb Sms LOC100912604 Ckmt1b Amd1 Gamt LOC100364487 Srm Kmo Kynu Ccbl1 Ido1 Tdo2 Lipt2 Amdhd1 Lipt1 Carns1 Agxt2 Hnmt Hal Bckdhb Amt Grhpr Hdc Ftcd Hao1 Hoga1 Uroc1 Gnmt Tas1r2 Ddo Dhtkd1 LOC100911564 Aldh4a1 Dbt Gldc Glul Agxt Iffo2 Lias Mpst Txn2 Suox Bckdk Cbs Bcat1 Sqrdl Bhmt2 Hsd17b10 Otc Ethe1 Bcat2 Hibadh Cdo1 Auh Cth Aldh6a1 Tstd1 Ivd Tst Acadsb Hibch Tmlhe Ppm1k Psmc5 Slc5a5 Psma1 Psma4 Psmc1 Psma3 Psmc4 Psma6 Psme1 Prodh Odc1 Psme2 Scly INOSITOL PHOSPHATE METABOLISM%REACTOME%R-RNO-1483249.1 Inositol phosphate metabolism Plcb1 Inpp1 Inpp5a Pten Isyna1 Plcb3 Synj1 Impa1 Inpp4a Impa2 Inpp4b Inpp5d Inpp5j Plcd3 Plcz1 Ipmk Plcd1 Ip6k2 Plcd4 Inpp5b Itpka Plce1 Pld4 Plch1 Plch2 Plcb4 Nudt11 LOC100912928 Nudt3 Minpp1 Ppip5k1 Ppip5k2 Nudt10 Plcg1 Ip6k1 Ippk Itpkb Nudt4 Itpkc Itpk1 Ocrl FORMATION OF ATP BY CHEMIOSMOTIC COUPLING%REACTOME DATABASE ID RELEASE 66%10145126 Formation of ATP by chemiosmotic coupling LOC100911417 Atp5f1 LOC500350 Atp5g3 Atp5l Atp5g2 Atp5o Atp5h Mt-atp6 Atp5i Atp5j Atp5j2 Atp5s Atp5e Atp5d Mt-atp8 Atp5b ACTIVATION OF SMO%REACTOME DATABASE ID RELEASE 66%10146091 Activation of SMO Csnk1a1 Dhh Cdon Shh Ptch1 Efcab7 Smo Iqce Evc2 Kif3a Arrb1 Boc Arrb2 Gas1 Ihh Gas8 Evc Adrbk1 GLI3 IS PROCESSED TO GLI3R BY THE PROTEASOME%REACTOME DATABASE ID RELEASE 66%10146075 GLI3 is processed to GLI3R by the proteasome Psmc6 Psmb10 Psmb8 Psmb9 Psmb4 Psmb11 Psmb5 Psmf1 Psmb6 Psmd4 Rbx1 Cul1 Psmb2 Psmd5 Psmd8 Psmd9 Psmb3 Psma8 Psmd11 Psmd12 Psmd13 Psmd14 Psmc3 Csnk1a1 Sufu G6pc Psmb7 Psmb1 Gli3 Skp1 Psma5 Btrc Psma2 Prkaca Psmc5 Psmd2 Prkacb Psma1 Psma4 Psmc1 Psma3 Psmc4 Psmc2 Psma6 Psme1 Psmd1 Psme2 Psmd7 Psmd3 Psmd6 RELEASE OF HH-NP FROM THE SECRETING CELL%REACTOME DATABASE ID RELEASE 66%10146062 Release of Hh-Np from the secreting cell Disp2 Dhh Ihh Shh Scube2 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES%REACTOME%R-RNO-2022090.1 Assembly of collagen fibrils and other multimeric structures Mmp7 LOC100911730 Mmp9 Pcolce RGD1308751 Cd151 Lamc2 Itgb4 Itga6 Col5a2 Col5a1 Cts8l1 Col4a5 Col9a1 Col27a1 Col9a2 Col9a3 Lox Col4a1 Plec Col5a3 LOC100364523 Bmp1 Col4a2 Col7a1 Lamb3 Dst Mmp13 Ctsb Col8a1 Ctsl Col8a2 Col3a1 Ctsm Ctsj RGD1564657 Col1a1 Ctsq Ctsr Col1a2 Col18a1 MGC114246 Tll2 Col11a2 Col11a1 Mmp20 Tll1 Testin Loxl4 Cts8 Cts7 Loxl1 RGD1564827 PEROXISOMAL PROTEIN IMPORT%REACTOME DATABASE ID RELEASE 66%10146282 Peroxisomal protein import Phyh Ide Nudt7 Hmgcl Acot4 Acot8 Acox1 Ehhadh Dhrs4 Eci3 Gstk1 Hsd17b4 Mlycd Acot2 Acot5 Acaa1a Acaa1b Pex2 Agps Hao1 LOC497963 Hao2 Pex5 Ddo Baat Pipox Gnpat Agxt Paox Amacr Usp9x Ube2d1 LOC100911156 Cat Ube2d3 Crot Pex14 Pex10 Pex13 Pex12 Acox3 Acox2 Slc27a2 Pex26 Idh1 Lonp2 Tysnd1 Pex1 Crat Zfand6 Pex6 Pex7 LOC103690024 Mpv17 Hacl1 Ech1 Ephx2 RECYCLING PATHWAY OF L1%REACTOME DATABASE ID RELEASE 66%10145501 Recycling pathway of L1 Ap2a2 Src Dnm1 Dnm3 Rdx Kif4a Msn Cltc Mapk1 Dpysl2 L1cam Ezr Clta Dnm2 Sh3gl2 Ap2s1 Ap2a1 Ap2m1 VASOPRESSIN REGULATES RENAL WATER HOMEOSTASIS VIA AQUAPORINS%REACTOME%R-RNO-432040.1 Vasopressin regulates renal water homeostasis via Aquaporins Myo5b Prkar2b Prkar2a Rab11fip2 Avp Prkar1b Gnb3 Prkar1a Aqp4 Gnb5 Gnb2 Rab11a Gnb1 Gng13 Gng12 Aqp1 Gng11 Prkaca Prkacb LOC100912034 Gnb4 Gng4 Gngt2 Gng5 Gngt1 Gng10 Gng8 Gng3 PI5P REGULATES TP53 ACETYLATION%REACTOME%R-RNO-6811555.1 PI5P Regulates TP53 Acetylation Ing2 Map2k6 LOC364561 Pin1 LOC100910954 Tmem55b Pip4k2b Pip4k2c HYPUSINYLATION%REACTOME%R-RNO-204626.1 Hypusinylation Eif5a Dohh Dhps Eif5a2 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1%REACTOME DATABASE ID RELEASE 66%10144899 Ubiquitin-dependent degradation of Cyclin D1 Psmc6 Psmb10 G6pc Psmb8 Psmb9 Psmb4 Psmb11 Psmb5 Psmf1 Cdk4 Psmb6 Psmd4 Psmb2 Psmd5 Psmd8 Psmb7 Psmd9 Psmb1 Psmb3 Psma8 Ccnd1 Psmd11 Psmd12 Psmd13 Psmd14 Psma5 Psma2 Psmc5 Psmc3 Psma1 Psmd2 Psma4 Psmc1 Psma3 Psmc4 Psmc2 Psma6 Psme1 Psmd1 Psme2 Psmd7 Psmd3 Psmd6 VEGFA-VEGFR2 PATHWAY%REACTOME DATABASE ID RELEASE 66%10145272 VEGFA-VEGFR2 Pathway Abi1 Abi2 Rac1 Nos3 Nck1 Rock2 Rictor Cyfip1 Fyn Ncf1 Brk1 Ncf4 LOC103692716 Baiap2 Trib3 Cybb Cyba Pak2 Pak3 Pak1 Them4 Nckap1l Ptk2 Cyfip2 Nck2 Nckap1 Akt2 Sh2d2a Prkcd Hspb1 Wasf1 Kras Src Rock1 LOC100909609 Ptk2b Pik3r1 Pxn Pik3r2 Shc2 Jup Akt1 Axl Prkcb Vav2 Vav1 Prkcz Mtor Ctnna1 Mapk13 Mapk12 Kdr Dscam Vav3 Crk Bcar1 Mlst8 Mapkapk3 Pdpk1 Mapkap1 Mapkapk2 Cdc42 Prkaca Pik3cb Akt3 Vegfa Prkacb Rhoa Prkca Plcg1 Dock1 Hras Ctnnd1 Nras Cdh5 Elmo2 Mapk14 Rasa1 Shb Mapk11 TRANSCRIPTIONAL REGULATION BY RUNX3%REACTOME%R-RNO-8878159.1 Transcriptional regulation by RUNX3 Psmc6 Psmb10 Mdm2 Psmb8 Psmb9 Maml1 Psmb4 Rbpj Psmb5 Kat2a Zfhx3 Psmf1 Psmb6 Psmd4 Rbpjl2 Psmb2 Psmd5 Psmd8 Psmd9 Psmb3 Psmd11 Psmd12 Psmd13 Psmd14 Smurf1 Snw1 Psmc3 Cbfb Yap1 Tead2 Tead1 Hdac4 Tgfb1 Crebbp Smad3 Notch1 Kras Src G6pc Psmb7 Psmb1 Ccnd1 Psma5 LOC100910954 Psma2 Psmc5 Brd2 Psmd2 Psma1 Psma4 Psmc1 Psma3 Psmc4 Psmc2 Psma6 Psme1 Tcf7 Lef1 Psmd1 Psme2 Tcf7l1 Psmd7 Psmd3 Psmd6 TP53 REGULATES TRANSCRIPTION OF DNA REPAIR GENES%REACTOME DATABASE ID RELEASE 66%10146165 TP53 Regulates Transcription of DNA Repair Genes Ccnt2 Gtf2h1 Gtf2h2 Tceb3 Cdk9 Mnat1 RGD1565904 Cdk12 Ercc3 Polr2g Polr2h Polr2e Supt16h Polr2f Polr2j Polr2k Ccnk Supt5h Polr2d LOC100911822 Polr2i Polr2b Cdk13 Polr2c Ercc2 Polr2a Gtf2f1 LOC100912534 Gtf2f2 Ell Supt4h1 Cdk7 Tceb2 Tceb1 Tcea1 Nelfe Nelfa Nelfb Ccnh Ssrp1 Gtf2h3 Gtf2h5 Gtf2h4 PI-3K CASCADE:FGFR2%REACTOME DATABASE ID RELEASE 66%10145254 PI-3K cascade:FGFR2 Gab1 Fgf16 Fgf17 Pik3r1 Fgf10 Fgf9 Fgfr2 Fgf7 Fgf2 Fgf8 Fgf23 Fgf22 Fgf4 Ptpn11 Fgf1 Fgf3 Fgf6 Fgf5 Frs2 Fgf20 Grb2 TRANSLESION SYNTHESIS BY REV1%REACTOME DATABASE ID RELEASE 66%10144976 Translesion synthesis by REV1 Rfc1 Rfc2 Rev1 Rpa1 Rpa3 Rpa2 Mad2l2 Rfc5 Rev3l Rfc4 Rfc3 Pcna SHC1 EVENTS IN ERBB4 SIGNALING%REACTOME DATABASE ID RELEASE 66%10145825 SHC1 events in ERBB4 signaling Ereg Kras Nrg1 Btc Nrg3 Hbegf Nrg4 Erbb4 Hras Nras Sos1 Shc1 Nrg2 Grb2 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM%REACTOME DATABASE ID RELEASE 66%10144896 Transport of Mature Transcript to Cytoplasm Nup93 Rnps1 Thoc5 RGD1565693 Thoc7 Thoc3 Nup43 Thoc2 Nup98 Nup133 Thoc1 Nup107 Magohb Aaas Rbm8a Thoc6 Nup210 Npap60 Nxf7 Nup35 Gle1 Nxf2 Nup37 Nxf1 Nupl2 Ddx39a Nupl1 Ddx39b Chtop U2af1l4 Sarnp Tcp11x2 Nup205 Nxt1 Ranbp2 Slu7 Srsf3 Upf3b U2af2 Srsf6 Nup155 Srsf7 Srsf4 Srsf5 Srsf2 LOC679894 Nup88 Srsf9 Dhx38 Nup85 Magoh Nup153 Ncbp2 Srsf1 Poldip3 Ncbp1 Tpr Fyttd1 Rae1 Eif4a3 LOC100910660 Srrm1 Nup54 Pom121 Nup62 Cdc40 LOC361990 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 66%10144717 CDT1 association with the CDC6:ORC:origin complex Psmc6 Psmb10 Psmb8 Psmb9 Psmb4 Psmb11 Psmb5 Psmf1 Psmb6 Psmd4 Psmb2 Psmd5 Psmd8 Psmd9 Psmb3 Psma8 Psmd11 Psmd12 Psmd13 Psmd14 Psmc3 Mcm8 Orc4 Orc5 Orc6 Orc1 Orc2 Orc3 Cdc6 Gmnn G6pc Psmb7 Psmb1 Psma5 Cdt1 Psma2 Psmc5 Psmd2 Psma1 Psma4 Psmc1 Psma3 Psmc4 Psmc2 Psma6 Psme1 Psme2 Psmd1 Psmd7 Psmd3 Psmd6 ACTIVATION OF BMF AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%R-RNO-139910.1 Activation of BMF and translocation to mitochondria Dynll2 Mapk8 Bmf CELL CYCLE, MITOTIC%REACTOME DATABASE ID RELEASE 66%10144721 Cell Cycle, Mitotic Rfc1 Rfc2 Pole2 Kif23 Pole4 Mnat1 Rbx1 LOC100910252 Stag1 Pds5b Pds5a Cdca5 Rad21 Smc1a Stag2 Smc3 Esco2 Esco1 Rpa3 Pole Pcna Ccnh Rfc5 Rfc4 Rfc3 Ube2d1 Rbl1 Cdk4 Akt1 E2f4 Hdac1 Rpa1 Ccnd1 Rpa2 RGD1310212 Tfdp1 Lig1 Tfdp2 Kif20a Slc25a16 Fen1 Prkca Lyn Cul1 Ptk6 Ensa Arpp19 Psmb7 Psmb1 Dsn1 Psma5 LOC100911727 Cdk7 Pold2 Pold1 Psma2 Pold4 Psmd2 Psmc2 Psmd1 Psmd7 Psmd3 Psmd6 Cep57 Rab8a LOC691918 Haus3 Prim2 Ccne2 Pola2 Ninl Ccne1 Prim1 Akap9 Ccp110 Mcm2 Mcm4 Mcm3 Cdk2 Mcm5 Mcm6 Mcm10 Mcm8 Mcm7 Orc4 Orc5 Orc6 Orc1 Orc2 Setd8 Orc3 Cdc7 Cdc6 Cdc45 Ppp2cb Ppp2ca Skp1 Ppp2r1a Fbxw11 Ppp2r1b Btrc Mapk1 Akt3 Hist1h2bo Cnep1r1 Hist1h2bcl1 Rbl2 Hist2h3c2 Hist1h2bk Gorasp2 H3f3b Cks1l E2f5 Hdac1l Cables1 Numa1 Dyrk1a Lemd2 Cdkn2b Nek6 Blzf1 Cdkn2c Hdac8 Cdk6 Cks1b Nek7 LOC100909949 Dctn1 Gmnn LOC100910200 Ccnd3 Cntrl Mcph1 H2afx Hist1h4b Dctn2 RGD1563307 Cep76 LOC684841 Hist1h2bh Pcm1 Cep78 Rb1 Ncapg LOC100912290 E2f2 Hist1h2ail1 Lemd3 Hist1h4m LOC100911033 LOC102549173 Cep164 Mau2 LOC103690002 Dctn3 Cep41 LOC100910152 Lmna Ofd1 LOC100912338 Vrk2 Hist1h3c Sdccag8 Ncaph2 H2afb3 Lin37 Hist1h3f Vrk1 Ctdnep1 Prkar2b Cenpj Hist2h4 Lin52 LOC684819 Hist1h3a Plk4 Lin54 Smc4 H2afj Hist2h2aa3 Tmpo Hist1h2bq Espl1 Hist2h2aa2 Smc2 Gins3 Gins4 LOC100364835 Gins1 LOC684762 Gins2 LOC100912076 Tubg2 Haus2 Haus1 Haus5 Alms1 Haus4 Odf2 Tubb4a Cdt1 Lmnb1 Lin9 Ncapg2 Ssna1 Tubg1 Cep63 Csnk1d Cep131 Tuba4a Cep250 Cep135 Csnk1e Cdk5rap2 Hist1h2bg Pcnt Cep72 LOC680097 Sfi1 Cep70 LOC684797 Actr1a LOC100912418 Hist1h2ba Nedd1 Hist3h2bb Cenpn Zwilch Cenpl Cenpo Dync1li2 Cenpt Cenpu Bub3 Bub1 Spdl1 Kntc1 Dync1i2 Mad1l1 Csnk2a2 Cenpk Cenph Cenpi Csnk2a1 Cenpf Cenpe Cenpm Ahctf1 Ndel1 Rcc2 LOC100909750 Pafah1b1 Ppp1r12a Mis12 LOC102555167 Dynll2 Ndc80 Cenpc Cenpa Dync1i1 Birc5 Taok1 Nup88 Nup85 Anapc7 Cdc26 Cdc14a Cdc27 Cdc23 Pttg1 Ube2c Skp2 Cdkn1a Cdkn1b Anapc16 Cdc16 Rae1 Nek2l1 Anapc4 Anapc2 Anapc1 Lpin2 Lpin3 Lpin1 Nek2 Nup93 Nup98 Rab2a Nup107 Nup210 Anapc11 Nupl2 Anapc15 Aurka Anapc10 Nupl1 Fzr1 Fbxo5 Cdca8 Cdc25c Rangap1 Ppp1cb Ppp1cc LOC100909468 Aurkb Sec13 Xpo1 Rab1b Nup205 Rab1a LOC100911204 Spc24 Spc25 Abl1 Itgb3bp Sgol2 Ppp2r5e Incenp G6pc Nup155 Nsl1 B9d2 Cdc20 Kif2a Kif2c Kif2b Bub1b Kif18a Ppp2r5c Ppp2r5a Ppp2r5b Zwint Mad2l1 Casc5 Nup153 Clasp2 Ercc6l Nuf2 Clasp1 Tpr LOC679582 Mapre1 Cdc42 Pmf1 Nup54 Ckap5 Pom121 Ska2 Nup62 Sgol1 Zw10 Ska1 Psmc6 Nup43 Psmb10 Nup133 Psmb8 Psmb9 Psmb4 Aaas Psmb11 Psmb5 Psmf1 Psmb6 Psmd4 Psmb2 Psmd5 Npap60 Psmd8 Psmd9 Psmb3 Nup35 Psma8 Nup37 Psmd11 Psmd12 Ccna2 Ccna1 Psmd13 Psmd14 Psmc3 Ajuba Ranbp2 Src Hsp90ab1 Tubb5 Ywhag Prkcb Ywhae Prkaca Ppp2r3b Bora Fbxl18 Fkbpl Fbxl7 Ppme1 Foxm1 Lcmt1 Tubgcp2 Dync1h1 Dync1li1 LOC103692716 Akt2 Gorasp1 Csnk2b E2f1 E2f3 Tpx2 Cdk11b LOC100910954 Cdk1 Gtse1 Psmc5 Phlda1 Psma1 Cdc25b Psma4 Cdc25a Psmc1 Wee1 Psma3 Pkmyt1 Psmc4 Ppp2r2a Psma6 Psme1 Nme7 Tubgcp5 Psme2 Tubgcp6 Tubgcp3 Tubgcp4 Optn LOC100909844 LOC100363782 Mzt1 Mzt2b NEGATIVE REGULATION OF MET ACTIVITY%REACTOME%R-RNO-6807004.1 Negative regulation of MET activity Ptpn1 Cbl Ptprj Hgf Ptpn2 Stam2 Sh3gl2 Sh3gl1 Sh3kbp1 Sh3gl3 Lrig1 Stam Usp8 Grb2 MTOR SIGNALLING%REACTOME DATABASE ID RELEASE 66%10145128 mTOR signalling LOC100912571 Eif4ebp1 Akt1s1 Akt1 Cab39l LOC100911431 Eef2k RragB Eif4g1 Lamtor3 Ywhab Prkab1 Strada Stradb Eif4b Prkab2 Rps6kb1 Cab39 Mtor Rheb Lamtor2 Prkag3 Lamtor1 Rptor Lamtor4 Tsc1 Lamtor5 Mlst8 Prkaa1 LOC100911372 Tsc2 Rraga Prkaa2 Rragc Rragd Slc38a9 Rps6 LOC680559 Akt2 PURINE CATABOLISM%REACTOME%R-RNO-74259.1 Purine catabolism Nt5c1a Nt5c Adprm Nudt9 Nt5e Nudt5 Nt5c2 Nudt16 Nudt18 Pnp LOC688828 Xdh Nt5c1b Nudt15 Nudt1 Gda Itpa Dnph1 PHENYLALANINE AND TYROSINE CATABOLISM%REACTOME%R-RNO-71182.1 Phenylalanine and tyrosine catabolism Pcbd1 Hpd Gstz1 Fah Tat Ccbl1 Hgd Il4i1 Pah Asrgl1 Qdpr SYNTHESIS OF DIPHTHAMIDE-EEF2%REACTOME DATABASE ID RELEASE 66%10146058 Synthesis of diphthamide-EEF2 Dph1 Dph3 Eef2 Dph2 Dph5 Dph6 TRIGLYCERIDE CATABOLISM%REACTOME%R-RNO-163560.1 Triglyceride catabolism Fabp3 Fabp2 Fabp6 Fabp1 Fabp4 Fabp9 Fabp12 Pnpla5 Fabp7 RGD1562200 Fabp5 Plin3 Gpd2 CD28 CO-STIMULATION%REACTOME DATABASE ID RELEASE 66%10145354 CD28 co-stimulation Cd80 Cd86 Src Pik3r3 Pik3r1 Map3k8 Pik3r2 Rac1 Akt1 Cd28 Vav1 Rictor Mtor Fyn Mlst8 Pdpk1 Trib3 Mapkap1 Cdc42 Akt3 Map3k14 Pak2 Pak3 Pak1 Lyn Them4 Yes1 Akt2 Grb2 REMOVAL OF AMINOTERMINAL PROPEPTIDES FROM GAMMA-CARBOXYLATED PROTEINS%REACTOME%R-RNO-159782.1 Removal of aminoterminal propeptides from gamma-carboxylated proteins Pros1 Proz Bglap F2 F7 F9 Gas6 Furin EGFR TRANSACTIVATION BY GASTRIN%REACTOME%R-RNO-2179392.1 EGFR Transactivation by Gastrin Kras Prkca Hras Nras Egfr Hbegf Sos1 Grb2 GENE SILENCING BY RNA%REACTOME DATABASE ID RELEASE 66%10145435 Gene Silencing by RNA Nup93 Nup43 Nup98 Nup133 Nup107 Aaas RGD1306195 RGD1565904 Nup210 Npap60 Polr2g Polr2h Nup35 Polr2e Polr2f Tnrc6b Nup37 Polr2j Polr2k Polr2d Nupl2 Tnrc6a Polr2i Tnrc6c Polr2b Polr2c Nupl1 Polr2a Hist1h2bo Hist1h2bcl1 Hist2h3c2 LOC100912534 Hist1h2bk H3f3b Nup205 Ranbp2 LOC100910200 H2afx Hist1h4b LOC684841 Hist1h2bh LOC100912290 Nup155 Hist1h2ail1 Hist1h4m LOC102549173 LOC103690002 LOC100910152 LOC100912338 Hist1h3c H2afb3 Hist1h3f Nup88 Hist2h4 LOC684819 Hist1h3a H2afj LOC100911822 Hist2h2aa3 Hist1h2bq Hist2h2aa2 Nup85 LOC100364835 LOC684762 Nup153 Prkra Ago3 Dicer1 Tsnax Ago4 Ago2 Tpr Rae1 Tsn Tarbp2 Nup54 Pom121 Hist1h2bg LOC680097 Nup62 LOC684797 LOC100912418 Hist1h2ba Hist3h2bb RUNX1 REGULATES GENES INVOLVED IN MEGAKARYOCYTE DIFFERENTIATION AND PLATELET FUNCTION%REACTOME%R-RNO-8936459.1 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function LOC100911167 Prmt6 Gata1 Hist1h2bo Hist1h2bcl1 Hist2h3c2 Hist1h2bk H3f3b Hdac1l Prmt1 LOC100911617 Cbfb Rbbp5 Runx1 LOC100910200 H2afx Hist1h4b Wdr5 Kmt2a LOC684841 Hist1h2bh LOC100912290 Hist1h2ail1 Zfpm1 Hist1h4m LOC102549173 LOC103690002 LOC100910152 LOC100912338 Hdac1 Hist1h3c H2afb3 Hist1h3f Hist2h4 LOC684819 Hist1h3a H2afj Hist2h2aa3 Hist1h2bq Hist2h2aa2 Ash2l LOC100364835 Dpy30 LOC684762 Sin3a Sin3b Hist1h2bg LOC680097 LOC684797 LOC100912418 Hist1h2ba Hist3h2bb ONCOGENE INDUCED SENESCENCE%REACTOME DATABASE ID RELEASE 66%10145265 Oncogene Induced Senescence Cdkn2b Ets1 Mdm2 Erf Ets2 LOC100910954 Mdm4 Cdkn2c Id1 Cdk4 Cdk6 Mapk1 BIOSYNTHESIS OF MARESIN CONJUGATES IN TISSUE REGENERATION (MCTR)%REACTOME DATABASE ID RELEASE 66%10146313 Biosynthesis of maresin conjugates in tissue regeneration (MCTR) Ltc4s Gstm4 ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS%REACTOME DATABASE ID RELEASE 66%10145721 Acetylcholine binding and downstream events Chrnb4 Chrne Chrnd Chrna4 Chrna5 Chrna9 Chrna6 Chrnb2 Chrna7 Chrnb3 Chrna2 Chrna3 Chrna1 LIPID PARTICLE ORGANIZATION%REACTOME%R-RNO-8964572.1 Lipid particle organization Fitm1 Fitm2 Cidec Hsd17b13 TYPE I HEMIDESMOSOME ASSEMBLY%REACTOME DATABASE ID RELEASE 66%10145647 Type I hemidesmosome assembly Cd151 Lamc2 LOC100911730 Itgb4 Dst Itga6 Plec Lamb3 Col17a1 METABOLISM OF INGESTED MESEO2H INTO MESEH%REACTOME%R-RNO-5263617.1 Metabolism of ingested MeSeO2H into MeSeH Txnrd1 PROTEIN METHYLATION%REACTOME%R-RNO-8876725.1 Protein methylation Prmt3 Mettl21a Mettl20 Mettl22 Eef2kmt Etfb Eef2 Kin LOC102553119 Rps2 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE%REACTOME DATABASE ID RELEASE 66%10145901 Synthesis of PIPs at the Golgi membrane Pi4k2a Pik3c3 Tpte2 Fig4 Pik3r4 Pi4kb Inpp5e Vac14 Pikfyve Pik3c2a Ocrl Sacm1l Pi4k2b Pik3c2g LAMININ INTERACTIONS%REACTOME DATABASE ID RELEASE 66%10145448 Laminin interactions Col18a1 Itga3 Nid1 Nid2 Lama4 Lamc1 Lamc2 Itgb4 Itga6 Lamb1 Itga7 Lamb2 Lama1 Lamb3 SMAC BINDS TO IAPS%REACTOME%R-RNO-111463.1 SMAC binds to IAPs Diablo LOC100360940 Xiap NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING%REACTOME%R-RNO-936440.1 Negative regulators of RIG-I MDA5 signaling Ddx58 Tbk1 LOC364561 Pin1 Tax1bp1 Mavs Irf3 Cyld Ikbke Tnfaip3 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM%REACTOME DATABASE ID RELEASE 66%10145731 Heparan sulfate heparin (HS-GAG) metabolism Ncan Agrn Xylt2 Dcn B3gat1 B3gat3 B3gat2 Hs6st2 LOC102550316 Cspg5 Cspg4 Sdc2 Hs6st1 Sdc3 Idua Sdc4 Gpc6 Bcan Vcan Hs3st3a1 Gpc4 Gpc2 Ndst1 Glb1l Ndst2 LOC100910284 Ndst3 Ndst4 Ext1 Ext2 Slc35d2 Glb1 Gusb B4galt7 Hpse Hs3st3b1 Hs2st1 Hs3st5 Naglu Gpc1 Hs3st2 Hs3st1 B3galt6 Hs3st6 APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS%REACTOME DATABASE ID RELEASE 66%10145386 Apoptotic cleavage of cell adhesion proteins Casp3 Dsg3 Dsg2 Ocln Tjp2 Pkp1 Cdh1 Dsp Dsg1 ASPARAGINE N-LINKED GLYCOSYLATION%REACTOME%R-RNO-446203.1 Asparagine N-linked glycosylation Mgat2 Mgat5 Sec24a Sec24b Dync1li2 Copa Sec24d Mgat3 Mgat1 Dync1i2 Man1c1 Man1a1 Cog4 Cog6 Cog8 Cog3 Cog1 Cog2 Sec23ip Lman1l Cog7 LOC102555167 Dynll2 Dync1i1 Ykt6 Sec24c Tmed7 Fuom Slc35c1 Tmed3 Tmed2 Napg Napb Fuk Napa Tsta3 Gmds LOC100911225 Fpgt Tmed9 Nsf Edem3 Calr Man1b1 Rnf139 Ganab Edem2 Uggt1 Trim13 Rnf5 Ngly1 Prkcsh Arcn1 Glb1 St3gal2 St3gal3 St3gal1 St3gal4 St3gal6 Trappc10 Canx Rnf103 Ppp6c Manea March6 Trappc2l Cd59 Ctsa Engase Trappc6a Trappc6b B4galt1 Ankrd28 Sec13 B4galt3 Sar1b B4galt2 B4galt6 B4galt4 B4galt5 Rab1b Rab1a Tmem115 Arfgap2 Ank1 Ctsc Golgb1 Arfgap3 Ctsz Mlec Arfgap1 Ubxn1 Spta1 Mcfd2 Preb Chst10 Capzb Nans Sptbn1 Rad23b Npl Sec31a Dhdds Cmas Stx17 Nanp Gosr2 Gosr1 Tmed10 Areg Stx5 Bet1 Arf5 Cnih1 Arf4 Lhb Ctage5 Asgr1 Gbf1 Cnih3 Cnih2 Asgr2 Tgfa Derl1 Man2a1 Fut8 Man2a2 Mgat4b Mgat4a Mvd Copz2 Copz1 Col7a1 F8 Lman2 Scfd1 Sec16a Sec16b Lman1 Cga Trappc2 Trappc5 Copb1 Chst8 Tfg Neu4 Neu2 Neu3 Neu1 Trappc3 LOC100910318 Kdelr1 Srd5a3 Tbc1d20 Capza2 Capza3 Kdelr2 Ppp6r3 Trappc1 Ppp6r1 Kdelr3 LOC100910557 Sptan1 Vcp Actr10 Dync1h1 Dync1li1 Copg1 Dctn5 Dctn6 Ins1 Ins2 Dctn4 Folr1 Dctn1 Dctn2 Uso1 Gorasp1 Dctn3 St8sia1 Alg1 Gfpt2 Nus1 Alg2 Dolpp1 Gfpt1 St8sia3 Alg6 Os9 Alg3 Alg9 Alg8 Renbp St3gal5 Mpi Pgm3 Pmm2 Alg14 Pmm1 Alg12 Sec22b Slc35a1 Cope St8sia5 Slc17a5 Sec23a St6galnac1 St6galnac2 Nudt14 LOC501189 St8sia4 Sec22a LOC100910177 Csnk1d Dolk St6gal1 St6gal2 Amdhd2 Psmc1 St6galnac4 St6galnac3 Nagk Gne Mpdu1 Man1a2 Dpagt1 St6galnac6 Gnpnat1 Dpm3 Actr1a Dpm2 LOC100363782 Dpm1 Sel1l Uap1 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE)%REACTOME%R-RNO-140877.1 Formation of Fibrin Clot (Clotting Cascade) F13a1 Pf4 Cd177 Klkb1 Kng1 F12 F11 Serpina5 Kng2 C1qbp LOC100909700 A2m Serpine2 Serpind1 Serping1 Tfpi Vwf F3 Fgb Fgg Kng1l1 Gp1ba Gp9 Serpinc1 Pros1 Gp5 Thbd Gp1bb F13b Fga LOC100911551 Procr Prcp F2r F2 F8 F7 F9 CD28 DEPENDENT PI3K AKT SIGNALING%REACTOME%R-RNO-389357.1 CD28 dependent PI3K Akt signaling Mtor Cd80 Cd86 Fyn Pik3r3 Pik3r1 Map3k8 Pik3r2 Mlst8 Trib3 Pdpk1 Akt1 Mapkap1 Cd28 Akt3 Map3k14 Them4 Akt2 Rictor TYSND1 CLEAVES PEROXISOMAL PROTEINS%REACTOME DATABASE ID RELEASE 66%10146324 TYSND1 cleaves peroxisomal proteins Tysnd1 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX%REACTOME%R-RNO-141430.1 Inactivation of APC C via direct inhibition of the APC C complex Anapc7 Cdc26 Cdc27 Cdc23 Ube2c Bub3 Ube2d1 Anapc16 Cdc16 Cdc20 Anapc4 Anapc2 Anapc1 Bub1b Anapc11 Anapc15 Mad2l1 Anapc10 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION%REACTOME%R-RNO-162658.1 Golgi Cisternae Pericentriolar Stack Reorganization Gorasp2 Rab2a Rab1b Rab1a Gorasp1 Blzf1 LOC100363782 LOC102555167 Mapk1 LYSOSOME VESICLE BIOGENESIS%REACTOME%R-RNO-432720.1 Lysosome Vesicle Biogenesis Ap4e1 LOC100909548 Ap4b1 Ap1g2 Ctsz Clvs1 Chmp2a Cltc Cltb Ap1m1 Clta App Dnm2 Vamp2 Ap1m2 Txndc5 Ap4m1 Bloc1s1 Dnase2 Ap4s1 Ap1b1 Vamp8 Arrb1 Sh3gl2 Ap1s3 M6pr Ap1s1 Ap1s2 Vamp7 PD-1 SIGNALING%REACTOME%R-RNO-389948.1 PD-1 signaling Cd247 Csk Pdcd1lg2 Pdcd1 Cd3g Cd274 LOC100911478 Ptpn11 Cd3e RT1-Ba Cd3d RT1-Bb Ptpn6 RT1-Da RT1-Db2 Cd4 RT1-Db1 LOC688090 TRANSPORT OF BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS%REACTOME%R-RNO-425366.1 Transport of bile salts and organic acids, metal ions and amine compounds Slc6a11 Slc6a13 Slc11a1 Slc6a1 Slc6a12 Rhag Slc44a4 Slc11a2 Slc44a5 Slc44a3 Rhcg Slc6a2 Heph Slc14a1 Slc18a1 Slc30a10 Slc22a15 Slc16a3 Slc6a7 Slc16a7 Slc6a9 Slc16a8 Slc16a1 Slc6a6 Slc22a5 Slc6a5 Slc39a2 Slc39a3 Slc39a4 Slc39a6 Slc44a2 Slc22a6 Slc22a3 LOC100911874 Slc22a7 Slc39a7 Slc22a1 Slc39a8 Slc22a2 Slc47a1 Slc6a3 Slc5a11 Runx1 Slc2a13 Slc30a5 Slc30a6 Slc30a8 Slc39a14 Bsg Slc31a1 Slc30a1 Slc6a15 Slc6a14 Slc6a19 Slc6a18 Slc6a20 Slc10a6 Slc13a4 Slc41a1 Slc41a2 Slc40a1 Slc13a1 Slc13a2 Slc13a3 Slc5a7 Cp SIGNALLING TO RAS%REACTOME DATABASE ID RELEASE 66%10145202 Signalling to RAS Shc3 Kras Shc2 Mapkapk3 Mapkapk2 Ralgds Hras Nras Sos1 Mapk14 Mapk11 Shc1 Grb2 ACTIVATION OF NF-KAPPAB IN B CELLS%REACTOME%R-RNO-1169091.1 Activation of NF-kappaB in B cells Psmc6 Psmb10 Psmb8 Psmb9 Psmb4 Psmb11 Nfkbib Psmb5 Psmf1 Psmb6 Psmd4 Cul1 Psmb2 Psmd5 Psmd8 Psmd9 Psmb3 Psma8 Psmd11 Psmd12 Psmd13 Rela Psmd14 Psmc3 Nfkbia G6pc Psmb7 Psmb1 Skp1 Prkcb Nfkbie Nfkb1 Psma5 Fbxw11 Chuk Btrc Psma2 Psmc5 Psmd2 Psma1 Psma4 Psmc1 Psma3 Psmc4 Psmc2 Psma6 Psme1 Psmd1 Psme2 Psmd7 Ikbkb Psmd3 Psmd6 NUCLEOSOME ASSEMBLY%REACTOME%R-RNO-774815.1 Nucleosome assembly Cenpn LOC100910200 Cenpl H2afx Cenpo Hist1h4b Mis18bp1 Hist1h2bh Cenpt Cenpu LOC100912290 Rbbp7 Hist1h4m LOC103690002 LOC100910152 LOC100912338 H2afb3 Cenpk Hist2h4 Cenph Cenpi Hjurp H2afj Hist2h2aa3 Hist1h2bq Hist2h2aa2 Cenpm Casc5 LOC100364835 Hist1h2bo Hist1h2bcl1 Hist1h2bk Cenpc Cenpa Cenpw Hist1h2bg Ruvbl1 LOC100911204 Smarca5 LOC680097 LOC684797 LOC100912418 Hist1h2ba Hist3h2bb Itgb3bp DDX58 IFIH1-MEDIATED INDUCTION OF INTERFERON-ALPHA BETA%REACTOME%R-RNO-168928.1 DDX58 IFIH1-mediated induction of interferon-alpha beta Tbk1 Ager Irf3 Cyld Nfkbib Ddx58 App LOC364561 Pin1 Tax1bp1 Mavs Rela Tnfaip3 Nfkb2 Nfkb1 S100b Dhx9 Chuk Ikbke Dhx36 Nkiras1 Nfkbia Nkiras2 Ikbkb Crebbp Myd88 EGFR DOWNREGULATION%REACTOME DATABASE ID RELEASE 66%10145266 EGFR downregulation Arhgef7 Eps15l1 Ptpn3 Egfr Spry2 Cbl Cdc42 Stam2 Sh3gl2 Sh3gl1 Sh3kbp1 Ptprk Spry1 Sh3gl3 Ptpn12 Stam Grb2 INTERLEUKIN-1 FAMILY SIGNALING%REACTOME DATABASE ID RELEASE 66%10145170 Interleukin-1 family signaling Psmc6 Psmb10 Psmb8 Psmb9 Psmb4 Psmb11 Psmb5 Psmf1 Psmb6 Psmd4 Psmb2 Rbx1 Psmd5 Psmd8 Psmd9 Psmb3 Psma8 Psmd11 Psmd12 Psmd13 Psmd14 Il1rl2 Il36rn Il1f10 Il1rap Il36b Il36a Psmc3 Sqstm1 Il1b Ube2n Il1rl1 Skp1 Nfkb2 Nfkb1 Mapk8 S100b Irak4 Dhx9 Fbxw11 Chuk Btrc Nkiras1 LOC100362142 Nod1 Nod2 Nkiras2 Tab2 Tab3 LOC100912618 Ube2v1 Ikbkb Myd88 Tnip2 Ripk2 Tbk1 Map2k6 Ager Map3k8 Peli3 Nfkbib Stat3 Peli2 Traf6 Cul1 App Il33 Tab1 Rela Map3k7 Peli1 Irak2 Nfkbia LOC100910771 Irak3 Il1r1 Il1rapl1 Map3k3 G6pc Il18r1 Psmb7 Psmb1 Il18 Il1a Casp1 Psma5 Tollip Psma2 Psmc5 Psma1 Psmd2 Psma4 Psmc1 Psma3 Psmc4 Psma6 Psmc2 Psme1 Psmd1 Psme2 Psmd7 Psmd3 Psmd6 SUMOYLATION OF INTRACELLULAR RECEPTORS%REACTOME%R-RNO-4090294.1 SUMOylation of intracellular receptors Nr1h4 Nr5a2 Nr1h3 Nr1h2 Sumo1 Pias3 Pias1 Sumo3 Nr5a1 Rxra Rora Nr1i2 Esr1 Ppara Hdac4 Pias4 Ube2i Pias2 Pgr Thra Thrb RUNX3 REGULATES P14-ARF%REACTOME DATABASE ID RELEASE 66%10146279 RUNX3 regulates p14-ARF Brd2 Kras Cbfb Ccnd1 Hdac4 Tgfb1 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS%REACTOME DATABASE ID RELEASE 66%10145174 ZBP1(DAI) mediated induction of type I IFNs Nfkb2 Nfkb1 Ager Irf3 S100b Dhx9 Nfkbib Chuk Nkiras1 App Nfkbia Nkiras2 Rela Ikbkb Myd88 PROTON OLIGOPEPTIDE COTRANSPORTERS%REACTOME DATABASE ID RELEASE 66%10145629 Proton oligopeptide cotransporters Slc15a1 Slc15a3 METALLOPROTEASE DUBS%REACTOME DATABASE ID RELEASE 66%10146145 Metalloprotease DUBs Bard1 Hist1h2aa Nlrp3 Fam175a Hist2h2ab Mysm1 Babam1 Bre Brca1 Brcc3 Stambp Stambpl1 Fam175b Hist2h2aa3 Hist2h2aa2 Psmd14 Uimc1 Stam ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION%REACTOME%R-RNO-450302.1 activated TAK1 mediates p38 MAPK activation Ripk2 Map2k6 Mapkapk3 Traf6 Mapkapk2 LOC100362142 Nod1 Nod2 LOC100910771 Tab2 Ube2n Tab3 Tab1 LOC100912618 Ube2v1 Mapk14 Map3k7 Mapk11 Irak2 NEGATIVE FEEDBACK REGULATION OF MAPK PATHWAY%REACTOME%R-RNO-5674499.1 Negative feedback regulation of MAPK pathway Raf1 Map2k2 Mapk1 ALPHA-OXIDATION OF PHYTANATE%REACTOME DATABASE ID RELEASE 66%10145549 Alpha-oxidation of phytanate Phyh Slc25a17 Aldh3a2 Slc27a2 Hacl1 LIGAND-DEPENDENT CASPASE ACTIVATION%REACTOME DATABASE ID RELEASE 66%10144860 Ligand-dependent caspase activation Faslg Traf2 Cflar Fadd Ripk1 Tradd Tnfsf10 Casp8 Fas PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE%REACTOME DATABASE ID RELEASE 66%10144782 Pyruvate metabolism and Citric Acid (TCA) cycle Mdh2 Idh3g Glo1 Idh2 Rxra Cs Sucla2 Ppard Slc16a3 Slc16a8 Slc16a1 Ldha Vdac1 Ldhb Me2 Hagh Fahd1 Me3 Sdhc Sdhd Sdha Me1 Dlst Sdhb Ogdh Bsg Pdpr Pdhb Pdk3 Pdk4 Pdk1 Pdk2 LOC100365902 Pdha2 Pdha1 Pdhx Pdha1l1 Suclg2 Ldhc Nnt Idh3a Gstz1 D2hgdh Pdp1 Aco2 Adhfe1 Idh3B Dlat L2hgdh Fh Dld CD28 DEPENDENT VAV1 PATHWAY%REACTOME DATABASE ID RELEASE 66%10145542 CD28 dependent Vav1 pathway Cd80 Cd86 Fyn Pak2 Pak3 Pak1 Vav1 Rac1 Grb2 Cd28 Cdc42 AMINE LIGAND-BINDING RECEPTORS%REACTOME%R-RNO-375280.1 Amine ligand-binding receptors Htr2c Adra1a Htr2a Htr2b Adra1d Chrm2 Chrm4 Taar9 Adra2a Hrh2 Htr5a Taar6 Htr4 Adra2c Adra2b Taar5 Taar2 Gpr143 Adrb3 Htr1d Htr1f Htr1a Hrh1 Htr1b Htr7 Hrh4 Chrm1 Chrm5 Drd5 Drd1 Drd4 Adrb2 Drd2 Chrm3 Htr6 MRNA DECAY BY 5' TO 3' EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 66%10145636 mRNA decay by 5' to 3' exoribonuclease LOC100360750 Lsm7 Lsm6 Lsm4 Lsm3 Lsm5 Dcp2 Lsm2 Dcp1a Lsm1 LOC679753 Patl1 Edc3 Edc4 Dcp1b MOLYBDENUM COFACTOR BIOSYNTHESIS%REACTOME%R-RNO-947581.1 Molybdenum cofactor biosynthesis Mocs1 LOC100911034 Mocs3 Mocos Nfs1 TRANSLESION SYNTHESIS BY Y FAMILY DNA POLYMERASES BYPASSES LESIONS ON DNA TEMPLATE%REACTOME DATABASE ID RELEASE 66%10144977 Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template Rfc1 Rfc2 Pole2 Pole4 Polh Vcp Ns5atp9 Poli Uba7 Usp43 Rev1 Rpa1 Rpa2 Ube2l6 Rchy1 Rpa3 Pole Pold2 Pcna Pold1 Pold4 Isg15 Trim25 Sprtn Nploc4 Usp10 Mad2l2 Rfc5 Rev3l Rfc4 Ufd1l Rfc3 HISTIDINE, LYSINE, PHENYLALANINE, TYROSINE, PROLINE AND TRYPTOPHAN CATABOLISM%REACTOME DATABASE ID RELEASE 66%10144795 Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism Ogdh Fah Tat Slc7a5 Pcbd1 Hpd Phykpl Kmo Kynu Ccbl1 Ido1 Hgd Il4i1 Pah Slc36a4 Asrgl1 Tdo2 Qdpr Amdhd1 Carns1 Hnmt Hal Gstz1 Hdc Ftcd Uroc1 Tas1r2 Aldh4a1 Pipox LOC100910122 Aldh7a1 Gcdh Aadat Dlst Prodh Iffo2 Hykk Dld SPERM MOTILITY AND TAXES%REACTOME%R-RNO-1300642.1 Sperm Motility And Taxes Catsper4 Kcnu1 Hvcn1 Catsper3 Catsper2 ENZYMATIC DEGRADATION OF DOPAMINE BY COMT%REACTOME DATABASE ID RELEASE 66%10145520 Enzymatic degradation of dopamine by COMT Maoa Comt Lrtomt REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE%REACTOME%R-RNO-176408.1 Regulation of APC C activators between G1 S and early anaphase Psmc6 Psmb10 Psmb8 Psmb9 Psmb4 Psmb11 Bub3 Psmb5 Psmf1 Psmb6 Psmd4 Psmb2 Cul1 Psmd5 Psmd8 Psmd9 Psmb3 Psma8 Psmd11 Psmd12 Ccna2 Anapc11 Ccna1 Anapc15 Psmd13 Psmd14 Anapc10 Fzr1 Fbxo5 Cdk2 Psmc3 G6pc Ube2d1 Cdc20 Psmb7 Psmb1 Bub1b Skp1 Mad2l1 Anapc7 Cdc26 Cdc27 Cdc23 Psma5 Ube2c Cdkn1a Cdkn1b Cdk1 Anapc16 Cdc16 Btrc Anapc4 Psma2 Anapc2 Anapc1 Psmc5 Psmd2 Psma1 Psma4 Psmc1 Psma3 Psmc4 Psmc2 Psma6 Psme1 Psmd1 Psme2 Psmd7 Psmd3 Psmd6 RNA POLYMERASE III TRANSCRIPTION%REACTOME%R-RNO-74158.1 RNA Polymerase III Transcription Bdp1 Polr3d Snapc3 Snapc4 Polr3c Polr3a Polr3e Polr3b RGD1565904 Polr3h Polr2h Polr3k Polr2e Polr2f Polr1c Polr3g Polr2k Polr3f Gtf3c6 Gtf3c5 LOC100912534 Gtf3c1 Gtf3c3 Gtf3c4 Polr3gl Brf1 Brf2 Pou2f1 Gtf3a Snapc5 Snapc2 Tbp ACTIVATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME DATABASE ID RELEASE 66%10144871 Activation of the phototransduction cascade Gnat1 Cngb1 Cnga1 Pde6b Gnb1 Gngt1 Pde6a Pde6g FERTILIZATION%REACTOME%R-RNO-1187000.1 Fertilization Kcnu1 Cd9 Catsper3 Catsper2 Izumo3 Izumo1 Catsper4 LOC100911976 Spam1 Acr Izumo4 Izumo2 Hyal5 Hvcn1 SIGNAL AMPLIFICATION%REACTOME%R-RNO-392518.1 Signal amplification Gnai3 Src P2ry1 Tbxa2r Gnaq Gna11 Gna14 Gna15 Gnat3 Pla2g4a Gna13 P2ry12 Gnai2 Gnb3 Gnb5 Gnb2 Gnb1 Gng13 Gng12 Gng11 LOC100912034 Gnb4 Gng4 Gngt2 Mapk14 Gnai1 Gng5 Gngt1 Gng10 Gng8 Gng3 ACTIVATED PKN1 STIMULATES TRANSCRIPTION OF AR (ANDROGEN RECEPTOR) REGULATED GENES KLK2 AND KLK3%REACTOME DATABASE ID RELEASE 66%10146086 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 LOC100910200 H2afx Hist1h4b LOC684841 Hist1h2bh LOC100912290 Hist1h2ail1 Hist1h4m LOC102549173 LOC103690002 LOC100910152 LOC100912338 Hist1h3c H2afb3 Hist1h3f Hist2h4 LOC684819 Hist1h3a H2afj Hist2h2aa3 Hist1h2bq Kdm1a Hist2h2aa2 LOC100364835 LOC684762 Hist1h2bo Hist1h2bcl1 Hist2h3c2 Pkn1 Hist1h2bk H3f3b Ncoa2 Hist1h2bg LOC680097 LOC684797 LOC100912418 Hist1h2ba Hist3h2bb PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE%REACTOME%R-RNO-174414.1 Processive synthesis on the C-strand of the telomere Rpa1 Slc25a16 Rpa3 Fen1 Rpa2 LOC100911727 Pold2 Pcna Pold1 Lig1 Pold4 IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 66%10145133 Immune System Kif3c Racgap1 Kif22 Kif3b Kif23 Stim1 Pias1 Kifap3 Myo1c Kif11 Ppie Kif4a Rbx1 Actb Sumo1 Pld4 Ube2v2 Ube2n Atox1 Brwd1 Akt1 Tlr7 Cd101 Tlr8 Irak4 Myo10 Eea1 Stx1a Kif26a Kif20a Map2k7 Nlrp4 Ripk2 Dtx4 Map2k6 Tbk1 Ager Ddx41 Dusp3 Nlrp4a Map2k4 Irf3 Trim21 Map3k8 Trim32 Dusp4 Peli3 Nfkbib LOC100912399 Peli2 Map3k1 Traf6 Cul1 Vrk3 Commd9 Rps6ka2 Rps6ka1 Pdxk App Cd53 Atg7 Rps6ka3 Xrcc6 Rps6ka5 Bpi Tirap Hbb-b1 LOC100912585 Xrcc5 Tab1 Dusp7 Dusp6 Rela Atf1 Atf2 Map3k7 Peli1 Irak2 Cd59 Np4 Ctsa Ptprc Cyfip1 Serpinb3a Cd63 Pnp Sdcbp RGD1304587 Cct2 Apaf1 LOC100909857 Ddost LOC498300 Vamp8 Defa7 Gdi2 Ptpn2 Anpep Plaur Serpinb12 Nfkbia Sh3gl2 Cct8 LOC100910771 Defa5 Sh3kbp1 Cst3 Dnajc13 Nckap1l Serpinb10 LOC100909879 Ilf2 Qsox1 Mpo Fcgr3a LOC685953 C1s Slc2a5 C1r Masp2 Cd36 Ctsc C1qb Colec10 Rock1 C4a Rap2b C1qa Syngr1 C4b Tmem179b Svip Serpinb1b Ctsz Mlec Arg1 LOC100909666 Frk Gzmm Serpinb1a LOC102549354 C2 Cstb Psmb7 Psmb1 Vapa Lrrc7 Prdx4 Gmfg C5ar1 Nme2 LOC687609 Dsn1 Lrmp Rap2c Grn Stom Dsp Cab39 Cd14 LOC100909700 Atp6v0a1 Ltf Psma5 Slpi Padi2 Plekho2 Rap1a Fcer1g Tollip Gsn Pkp1 Chi3l1 Psma2 Pglyrp1 Snap29 Psmd2 Commd3 Idh1 Bst1 Ptpn6 Psmc2 Fgl2 Tnfaip6 Psmd1 Psmd7 Iqgap1 Prdx6 Ppl Tspan14 Psmd3 Psmd6 Sh2b1 Ptpn1 Fbxl19 Gh1 Ghr Fbxl12 Fbxl13 Fbxl16 Fbxl15 Prl Csf1 Colec11 Ube2z Ube2s Fbxl4 Fbxl5 Fbxl8 Lbp Ptpn4 Jun Cd3e RT1-Ba Ppp2cb RT1-Bb Ppp2ca RT1-Da Skp1 RT1-Db2 Ppp2r1a RT1-Db1 LOC688090 Nfkb2 Nfkb1 Mapk9 Mapk8 Fos S100b Mapk7 Dhx9 Fbxw11 Chuk Ppp2r1b Ecsit Eif4a3 Mapkapk3 Btrc Mapkapk2 Mapk1 Nkiras1 LOC100362142 Nod1 Nod2 Nkiras2 Creb1 Tab2 Tab3 LOC100912618 Ube2v1 Ikbkb Mapk14 Myd88 Tnip2 Mapk11 Mapk10 Stat5a Jak3 Il22 Il24 Il19 Stat1 Il22ra1 Jak1 Stat2 Stat3 Il10rb Hsp90b1 Colec12 Ap1m2 Hist2h3c2 Smarca4 Eif4g2 Eif4g3 Flnb Isg15 Trim25 Eif2ak2 Ppm1b Eif4e3 Mx1 Il22ra2 Mx2 Il20ra Il20rb Tyk2 Ifnl3 Il20 Ifnlr1 LOC684841 Eif4e2 Arih1 Hist1h2ail1 LOC102549173 RT1-DMa RT1-DMb Hist1h3c Cd74 Lag3 Hist1h3f Rilp LOC684819 Hist1h3a Ifi30 LOC100909593 LOC100909630 RT1-DOb RT1-DOa Ctse Ctsf LOC684762 RGD1560225 Ppp3ca Nfatc2 Tec Txk Lat Plcg1 Nfatc3 Lcp2 Itk Sec24a Sec24b Sec24d Pde12 Oasl Asb18 Rnasel Abce1 Asb11 Asb12 Asb13 Cnpy3 Asb14 Unc93b1 Asb10 Tlr3 Keap1 Vamp2 Asb15 Asb17 Asb16 Ddx3x Plac8 RGD1563818 Cotl1 Cmtm6 RT1-A2 Lpcat1 RT1-A1 Ggh Clec5a B2m LOC100125364 Glipr1 Rnaset2 Ap1b1 Gpr84 RGD1561778 Ist1 Cpped1 Cand1 A1bg Stx4 Clec4d Sec24c LOC100911393 Pdzd11 Ptpn22 Anapc7 Cdc26 Cdc27 Cdc23 Fbxl22 Lrrc41 Ube2c Crk Skp2 Fbxw10 Cdc16 Fbxw12 Anapc4 Anapc2 Anapc1 Ifnar2 Ifna5 Traf2 Ifna4 LOC100912356 LOC100911527 Ifna11 LOC100912859 Ifnar1 RGD1560539 Ifna2 Ap1s3 Ifnb1 Ap1s1 LOC103690314 Ap1s2 LOC100912314 Ifna16l1 RGD1565911 RGD1561827 Il33 Anapc11 Anapc10 Fzr1 Usp18 Irf9 Tnfsf13b Tnfrsf9 Tnfrsf8 Edaradd Tnfrsf4 Eda2r Ifngr2 Klhl5 Ifngr1 Cd70 Tnfrsf17 Tnfsf8 Tnfsf9 Tnfrsf25 Edar Prmt2 Tnfrsf11b Tnfrsf11a Tnfsf4 Tnfsf14 Tnfsf12 Tnfrsf12a Tnfrsf13c Eda Tnfsf11 Capzb Lta Klhl2 Ltb Ltbr Fbxo2 Il9r Il15 Cd27 Ifng Il9 Fbxo9 Fbxo7 Fbxo6 Fbxo4 Ube2k Ube2h Ube2f Sec31a Ube2a Il10ra Il10 Klhl9 Lrr1 LOC100912571 Atp6v1d Cda Lamp1 Ftl1 Psap RatNP-3b Svs1 Fuca2 Rnf123 Serpinb6b Igf2r Lrg1 RGD1306474 Magt1 Rac1 Acly Cap1 Bpifb2 Pdap1 Doxl2 Doxl1 Cpne3 Rnase17 Rab27a Ccnf Psmd11 Psmd12 Ube2e3 Fabp5 Dynlt1 Psmd13 Psmd14 Eif4g1 Tmem30a Lamp2 Unc13d Rictor Mif Ap2a2 Crisp3 Cfp S100a11 Aga Cfd RT1-M3-1 Serpinb3 Atp8a1 Kcmf1 Tceb2 Tceb1 Aldh3b1 Cul2 Ndufc2 Serpinb6 Aprt Faf2 Cpne1 Psmc3 Diaph1 Trpm2 LOC100364500 Defa11 Fcnb Defa10 RT1-S3 Bcl10 Eif4a2 Cant1 Tmem173 Cxcr2 Atp6v0c Eif4a1 RGD1564463 Rbsn LOC680559 Anxa2 Mgst1 Retn RT1-CE2 Kctd7 Dpp7 Nit2 RT1-CE3 Src RT1-CE4 Rnf7 RT1-CE7 RT1-CE5 Slco4c1 Hsp90ab1 RGD1561661 Rab3a Copb1 Cat Cd177 RT1-CE10 Hebp2 Cltc Rab7a Ptges2 Ptafr Clta Tubb5 Creg1 Pigr Mettl7a Alox5 Prkcb Kbtbd8 Kcnab2 Ywhaz Ap2s1 Pygb Ppp3r1 Bcl2 Rab4b Kbtbd7 Ticam2 Kbtbd6 Mme Ywhab Ap2a1 Neu1 Lta4h Kctd6 Ms4a3 Ap2m1 Cxcl2 Cxcl1 Epx Ube2q2 S100a8 Cd68 Ube2r2 Rab5b Cxcl3 Rab5c Chit1 Ampd3 Hspa5 Slc27a2 Capza2 Capza3 Dgat1 Rab6a LOC683761 LOC100364956 Gan Atp6ap2 Tmem63a Ptprn2 Nhlrc3 Naprt1 Ano6 Pa2g4 Gm2a Dbnl Fcgr2b LOC103693683 Atad3a Serpina3m Rab9b Fcgr2a Trappc1 Tnfsf13 Tlr2 Plau Slc11a1 PVR Kpnb1 Chrnb4 Fpr1 Arl8a Pld1 Ostf1 Ear1 Cd40 Vcl Cd34 Prg3 Siglec1 Mill1 Erp44 LOC680910 Stk10 Sptan1 LOC685157 Vcp Cd200 Prg2 Hcst Asb5 Rab18 Cd300lb Ghdc Asb6 Siglec15 Cd300le Asb7 LOC100910990 Kir3dl1 Slpil3 Pianp Cd300e Klhl41 Rab10 Asb1 Rab14 Cd300lg Asb3 Cd1d1 Slpil2 Vnn1 Cdc34 Cd300lf Crtam Asb8 Rab24 Actr10 LOC685048 Nbeal2 RGD1559588 Klhl42 Lamtor3 Sh2d1b2 RT1-A Pilra Arsa Cd22 RGD1566006 Tmbim1 Dok3 LOC685438 Tnfaip3 Dync1h1 P2rx1 Acaa1a Acaa1b Lamtor2 Lamtor1 Apeh Ypel5 Dync1li1 Fbxo41 Slc44a2 LOC103692716 Qpct Fbxo44 Fbxo40 RGD1565355 Cybb Cyba LOC361635 Wsb1 Actr1b Dctn5 RT1-M2 Hmha1 Dctn6 Lgals3 Spsb2 RT1-M5 Spsb1 RT1-M4 Nfam1 Ubr4 Crispld2 Pycard Crebbp Stk11ip Dctn4 Rab3d Rbm12 Spsb4 Galns Gca C3ar1 Btbd1 Btbd6 Prkcd Fbxo22 Armc8 Ube2g2 Olfm4 Kras Ube2g1 Fcar Gstp1 Asah1 Mnda Pik3r1 Il6 Bri3 Pik3r2 Klhl13 Ptx3 Srp14 Fbxo30 Pdcd1lg2 Tcirg1 Fbxo31 Hmox2 Ptprj Klhl11 Tnfrsf14 Jup Fbxo32 Btla Icoslg Fbxo21 Mospd2 Impdh1 Cd28 Impdh2 Pdcd1 Ddx58 Ap1m1 Cd274 Klhl20 LOC100911478 Nfasc Icos Rnase3 LOC100360575 Rnase2 Enpp4 Sirpa LOC100911431 Tyrobp LOC100360087 Cdk13 Zbtb16 LOC299277 Klhl25 Golga7 Klhl21 Hvcn1 Uba1 Stbd1 Klhl22 Dsg1 Txndc5 Fbxo10 Dnajc5 Csnk2b Actr2 Fgr Alad Fbxo15 Gla Dnajc3 Fbxo11 Tnfrsf1b Sec22b Arhgap9 RGD1559482 Sec23a C3 Fbxw2 RT1-M6-1 Uba6 Rnf34 Lair1 Ppbp Mapkap1 Atp11a Vat1 Aoc1 Pik3cb Fbxw9 Uba3 Map3k14 RT1-M6-2 Ptpn11 Agpat2 Relb Rhoa Fbxw5 Eef2 Fbxw4 Arpc5 Fbxw8 Gsdmd Fbxw7 Prcp Cyb5r3 Hras Nras Rhof Rhog Sos1 Ckap4 Tbc1d10c Shc1 Degs1 Tom1 Grb2 Rnf41 Vhl Socs5 Socs3 Nos3 RGD1308751 Dnm2 Itga4 Mavs Tnf Bpifa2 Atp6v1g1 Rnase6 Atp6v1g2 Atp6v0a4 Bpifa1 Rbck1 Atp6v1b2 Atp6v0a2 Fyn Atp6v1h Atp6v1f Stat6 LOC497963 Il1rl2 Il36rn Il1f10 Il1rap Il36b Il36a Bpifb4 Pglyrp3b Pglyrp3 Bpifb6 Pglyrp4 Pglyrp2 Itln1 Eppin Bpifa2f Chga Bpifa5 Rap1gap2 Reg3g Sipa1 Elane Adam8 Pik3ap1 Ube2d1 Il1rl1 Vcam1 LOC103690254 Try10 Atp6v0d1 LOC100365995 Herc2 Atp6v1c2 Atp6v0d2 Timp2 Ube2d3 Atp6v1a Atp6v0e2 Atp6v0e1 Atp6v1g3 Atp6v1e1 Atp6v1e2 Atp6v1c1 Stub1 Nos1 Calr MGC114246 Capn1 Testin Lyn Crkl Yes1 Hck Rapgef1 Ceacam10 Syk LOC100911248 Mmp8 Camk2g Itgam Mmp9 Try4 Camk2d Itgb7 Camk2a Madcam1 Wwp1 Itgb2 Canx Vtn Atp7a Ceacam1 Prkcq Siah1 Tlr4 Prss2 Ikbke Tank Traf3 Siah2 LOC100364523 Sar1b Apob Itgal Itgax Prss1 Icam4 Icam5 Il2rg Icam1 Rap1gap Ctsd Ctsb Ctsg Trem2 Ctsl Ctsm Ctsj RGD1564657 Vav2 Ctsk Ctsq Vav1 Ctsr LOC100909977 P4hb LOC102554637 Dnm1 Csk Dnm3 Vav3 Rasgrp1 Rasgrp3 Sos2 Il5 Cts8 Cts7 Il2 Il2ra Csf2 RGD1564827 Il3ra Icam2 Il2rb Pten Csf2ra Csf2rb Pla2g6 Raf1 Il5ra Psen1 Ncstn LOC364561 Pin1 LOC683849 Cd47 Cts8l1 Rasgrp2 Ttr Kif3a Il1b F2 Mre11a Pik3r3 Inpp5d Mtor Cpb2 Txn1 Mlst8 Akt3 Cd80 Cd86 Lgmn Lat2 Trem1 Ifitm3 Cd40lg Cd226 Smurf1 LOC100911324 Pvrl2 Ifitm2 Ifitm1 Sh2d1a Sh2d1b Ube2m Cd8b Cbl Cd8a RGD1561143 Slamf7 Siglec10 Slamf6 Npdc1 Treml2 Cd200r1 Cd200r1l LOC681182 Cd96 Dctn1 Dctn2 Il6st Dctn3 Myo9b Actr1a Il21r Klc1 Dync1li2 Il21 Abi1 Abi2 Potef Dync1i2 Panx1 Uba7 Myh9 Casp3 Nck1 Traf7 Glmn Uba5 Hecw2 Klc4 Mrc2 Sugt1 Ube2l6 Rbbp6 Cenpe Mrc1 Txnip Ube3d Klc2 Ube3b Mefv Pstpip1 Trim11 Klc3 P2rx7 Lrsam1 Ube3a Npepps Ube2o Arpc1b Ube2u Hectd3 LOC100909750 Hectd1 Rnf6 Erap1 Ncf1 Rnf4 Ncf4 Cd207 Tap1 Tap2 Traip Rnf25 Anapc13 Lnx1 Rnf19a Dynll2 Rnf19b Herc3 Sqstm1 Arih2 Herc6 Tapbp Dync1i1 Tpp2 Ubox5 Ube2j2 Arel1 Ube2j1 Ptk2 Rnf182 Actg1 Cyfip2 Rnf14 Ltn1 Nckap1 Cblb Sh3rf1 Pja1 Defb26 Pja2 Defb28 Ccr6 Hexb Dtx3l Defb30 Znrf2 Defb18 Znrf1 LOC100909609 Trim9 Defb36 Blmh Ptk2b Defb14 LOC100911400 Defb12 Pld2 Rnf115 Trim63 Dzip3 Trip12 Ubr2 Trim71 Defb29 Vprbp Defb49 Trim69 Defb25 Trim39 Defb43 Ube4a Defb44 LOC100910646 Ufl1 Trim50 Tax1bp1 Ubac1 Ube2q1 Thop1 Art1 Rlim Defb13 Mex3c Rchy1 Defb41 Defb1 Mgrn1 Pik3cd Trim41 Defb22 Hace1 Defb23 Trim36 Defb20 Trim37 Defb21 Fcgr1a Cd247 Pkm Nlrp3 Rnf144b Pgam1 Glb1 Dock1 Elmo2 Klrc2 Manba Fyb Aldoa Gyg1 Aldoc Cpn1 Cpn2 Cr2 Clu C5ar2 Cd46 Serping1 Brk1 Pfkl C6 Cfhr1 Pgm2 Cd19 C8g Pgm1 RGD1564614 Baiap2 Cd81 B4galt1 LOC100909468 C8a C8b Limk1 Sec13 Nf2 Pak2 Pak3 Pak1 Cfh Wasl Aldoart2 Abl1 Wasf1 Arpc4 Ppp2r5e G6pc Agl Arpc3 Cdc20 Kif2a Pla2g2a Kif2c Kif2b Kif18a Ppp2r5c Ppp2r5a Gpi Nckipsd LOC100361457 Ppp2r5b Xdh Cd209b Kif5b Cd209e Btn2a2 Kif5a Clec4m Cd79b Actr3 Cd79a Nfkbie Was Blnk Btn1a1 LOC684480 Mapk13 Cd209a Mapk12 Btnl2 Pik3c3 Dapp1 Cd79al Arsb Pik3r4 Pdpk1 Dhx36 Cdc42 Dera LOC100911597 Gusb Hpse Man2b1 Wipf1 Wipf2 Wipf3 Cd44 Psmc6 Psmb10 Psmb8 Gaa Psmb9 Psmb4 Psmb11 Psmb5 Pygl Psmf1 Psmb6 Psmd4 Psmb2 Psmd5 Psmd8 Psmd9 Psmb3 Psma8 Ppapdc1a Pld3 Ppapdc1b Prkaca Prkacb Itpr1 Rapgef4 Itpr3 Fbxl18 Fbxl7 Tlr9 Cd4 Irs2 Trib3 Il13ra1 Clcf1 Il13ra2 Il12b Il31ra Irak3 Il12a LOC100360218 Them4 Cntf Irs1 Csf3 Il23r Il1r1 Crlf2 Ebi3 Akt2 Il4r Il17c Il1rapl1 Map3k3 Il17a Il23a Birc3 Crlf1 Birc2 Aim2 Il4 Cyld Lif Stxbp2 Csf1r Ptprz1 Il13 Txlna Il11ra1 Tlr6 Lifr Il18r1 Tlr10 Il12rb1 Il12rb2 Csf3r Il17rc Il11 Stx3 Il18 Il16 Casp4 Ctf1 Casp1 Il1a Casp2 Il25 Osmr Nlrp1a Il17rb Il17ra Casp8 Il17re Il27ra Casp9 Socs1 Cntfr Osm Mylip Psmc5 Psma1 Cd3g Psma4 Psmc1 Psma3 Cd3d Psmc4 Psma6 Psme1 Psme2 Vamp3 LOC100909844 Vamp7 PORPHYRIN METABOLISM%REACTOME DATABASE ID RELEASE 66%10145085 Porphyrin metabolism Hmox1 Ugt1a8 Ugt1a9 Ugt1a6 Alad Blvrb Blvra Hmox2 Ugt1a1 Cpox Fech LOC687381 Ugt1a7c Ppox Ugt1a5 Hmbs Ugt1a3 Cox10 Ugt1a2 Alas2 LOC100911779 Cox15 Urod Uros RA BIOSYNTHESIS PATHWAY%REACTOME%R-RNO-5365859.1 RA biosynthesis pathway Dhrs3 Cyp26c1 Crabp1 Sdr16c5 Dhrs4 Rdh14 Rdh13 Aldh8a1 Dhrs9 Rdh10 Rdh16 Akr1c2 LOC100365958 Akr1c3 Akr1c12l1 Akr1c19 Rdh11 Cyp26a1 Adh6 Akr1c13 Akr1c14 RGD1564865 Akr1c12 Akr1c1 Cyp26b1 CLASSICAL KIR CHANNELS%REACTOME DATABASE ID RELEASE 66%10145835 Classical Kir channels Kcnj2 Kcnj4 Kcnj14 Kcnj12 REGULATION BY C-FLIP%REACTOME DATABASE ID RELEASE 66%10146009 Regulation by c-FLIP Faslg Traf2 Cflar Fadd Ripk1 Tradd Tnfsf10 Casp8 Fas PROTEIN UBIQUITINATION%REACTOME DATABASE ID RELEASE 66%10146215 Protein ubiquitination Usp7 Leo1 Cdc34 Ube2e3 Ctr9 Hist1h2bo Wdr61 Hist1h2bcl1 Pex2 Hist1h2bk Rad18 Pex5 Ube2z Pcna Ube2t Rnf152 Ube2s Uchl3 RGD1561252 Ube2v2 Ube2n Shprh Bcl10 Rnf20 Paf1 Rnf181 Cdc73 LOC100910200 Ube2g2 LOC100911393 Ube2g1 Hist1h2bh Usp9x Ube2d1 Rtf1 LOC100912338 Rnf40 Ube2d3 Otulin Hist1h2bq Uba1 LOC100364835 Pex14 Pex10 Pex13 Ube2q2 Pex12 Hltf Ube2r2 Ube2c Ube2k Ube2h Uba6 Rraga Ube2a Usp5 Hist1h2bg LOC103690024 LOC100911959 LOC684797 Hist1h2ba THROMBOXANE SIGNALLING THROUGH TP RECEPTOR%REACTOME%R-RNO-428930.1 Thromboxane signalling through TP receptor Gnb3 Gnb5 Tbxa2r Gnb2 Gnb1 Gnaq Gng13 Gna11 Gna14 Gng12 Gna15 Gng11 LOC100912034 Gnb4 Gng4 Gna13 Gngt2 Gng5 Gngt1 Gng10 Gng8 Gng3 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN%REACTOME%R-RNO-174154.1 APC C:Cdc20 mediated degradation of Securin Psmc6 Psmb10 Psmb8 Psmb9 Psmb4 Psmb11 Psmb5 Psmf1 Psmb6 Psmd4 Psmb2 Psmd5 Psmd8 Psmd9 Psmb3 Psma8 Psmd11 Psmd12 Anapc11 Anapc15 Psmd13 Anapc10 Psmd14 Psmc3 G6pc Ube2d1 Cdc20 Psmb7 Psmb1 Anapc7 Cdc26 Cdc27 Psma5 Cdc23 Pttg1 Ube2c Anapc16 Cdc16 Anapc4 Psma2 Anapc2 Anapc1 Psmc5 Psmd2 Psma1 Psma4 Psmc1 Psma3 Psmc4 Psmc2 Psma6 Psme1 Psmd1 Psme2 Psmd7 Psmd3 Psmd6 SHC1 EVENTS IN EGFR SIGNALING%REACTOME%R-RNO-180336.1 SHC1 events in EGFR signaling Kras Hras Nras Egfr Sos1 Shc1 Grb2 CHYLOMICRON REMODELING%REACTOME DATABASE ID RELEASE 66%10145241 Chylomicron remodeling Lpl Apob Apoa1 Gpihbp1 Apoc2 Apoe Apoa2 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA%REACTOME%R-RNO-72203.1 Processing of Capped Intron-Containing Pre-mRNA Thoc5 Thoc7 Thoc3 Thoc2 Thoc1 Ppie Thoc6 RGD1565904 Isy1 Polr2g Polr2h Polr2e Polr2f Polr2j Polr2k Polr2d Polr2i Polr2b Polr2c Ddx39a Polr2a Ddx39b Xab2 Chtop LOC100912534 Prpf19 Nup88 LOC100911822 Aqr Nup85 Fyttd1 Rae1 LOC361990 Nup93 Rnps1 Dhx16 Dhx15 Sugp1 Prpf40a Nup98 Sart1 Nup107 Snrpb2 Magohb Phf5a Rbm8a Ddx23 Pcf11 Fip1l1 Hnrnpa0 U2surp Nup210 Nudt21 Snrpd1 Eftud2 LOC100364748 Snrpd2 Snrpd3 Rbm5 Tra2b Sf3b2 Nupl2 Sf3b4 Sf3b3 Pqbp1 Nupl1 Sf3b5 Cstf2 Rbm22 Lsm8 Puf60 Wbp11 Lsm7 U2af1l4 Lsm6 Lsm4 Lsm3 Lsm5 Cpsf7 Cpsf2 Cpsf3 Cpsf4 Lsm2 Rbm17 Cstf1 Snrnp200 Cpsf1 Smptb Sarnp Gpkow Plrg1 LOC679753 Prpf6 Sf3a3 Sf3b1 Prpf8 Nup205 Prpf4 Ddx46 Sf3a1 Prpf31 Ddx42 Bcas2 Slu7 Prpf3 Sf3a2 Crnkl1 LOC100360750 Syf2 Fus Smndc1 Prcc Rbmx LOC100359916 Nup155 Snrpa1 Snrnp70 LOC679894 Nup153 Poldip3 Tpr Nup54 Pom121 Nup62 Cwc27 Cwc25 Cwc22 Nup43 Snrpf Nup133 Wdr33 Aaas Npap60 Nup35 Snrnp25 Zrsr1 Zcrb1 Nup37 Zmat5 Snrnp48 Rnpc3 Zrsr2 Snrnp35 Pdcd7 Ranbp2 Srsf3 Ccar1 Cdc5l Upf3b U2af2 LOC102548514 Cd2bp2 Papola Srsf6 Elavl1 Srsf7 Ppil6 Prpf38a Srsf4 Srsf5 Srsf2 Hnrnph1 Ppih LOC100359574 Ppil1 Ppil3 Elavl2 Srsf9 Ppil4 Dhx38 Fblim1 Clp1 Hnrnph2 Cwc15 Cherp Magoh Hnrpd Ncbp2 Srsf1 LOC100363335 Ctnnbl1 Ppwd1 LOC500684 Wtap Ncbp1 Dhx9 LOC680519 Ybx1 LOC100910750 Nhp2l1 Cstf2t Eif4a3 Sympk Bud31 Hnrnpul1 Txnl4a LOC100910660 Hnrnpk Srrm1 Hnrnpu Hnrnpr Wbp4 Usp39 Hnrnpl Snrpa Hnrnpm Hnrnpf Cdc40 Snrpc Hnrnpa2b1 Snrpb RGD1565693 Nxf7 Gle1 Mettl14 Nxf2 Nxf1 Gtf2f1 Gtf2f2 Snw1 Mettl3 Tcp11x2 Ddx5 Nxt1 INSULIN RECEPTOR RECYCLING%REACTOME%R-RNO-77387.1 Insulin receptor recycling Atp6v1d Tcirg1 Atp6v0d1 Atp6v1c2 Atp6v0d2 Atp6v1a Atp6v0e2 Atp6v0e1 Atp6ap1 Atp6v1g3 Atp6v1e1 Atp6v1e2 Atp6v1c1 Atp6v1g1 Atp6v1g2 Atp6v0a4 Atp6v0a1 Atp6v1b2 Atp6v0a2 Atp6v1h Atp6v1f Insr Ins1 Ins2 Atp6v0c INTERLEUKIN-6 SIGNALING%REACTOME DATABASE ID RELEASE 66%10145796 Interleukin-6 signaling Socs3 Ptpn11 Stat1 Il6st Jak1 Il6 Stat3 Cbl Tyk2 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%R-RNO-111447.1 Activation of BAD and translocation to mitochondria C-SRC MEDIATED REGULATION OF CX43 FUNCTION AND CLOSURE OF GAP JUNCTIONS%REACTOME%R-RNO-191647.1 c-src mediated regulation of Cx43 function and closure of gap junctions EUKARYOTIC TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 66%10144835 Eukaryotic Translation Initiation TIE2 SIGNALING%REACTOME%R-RNO-210993.1 Tie2 Signaling SMALL INTERFERING RNA (SIRNA) BIOGENESIS%REACTOME%R-RNO-426486.1 Small interfering RNA (siRNA) biogenesis ARACHIDONATE PRODUCTION FROM DAG%REACTOME%R-RNO-426048.1 Arachidonate production from DAG NUCLEOTIDE EXCISION REPAIR%REACTOME%R-RNO-5696398.1 Nucleotide Excision Repair CAP-DEPENDENT TRANSLATION INITIATION%REACTOME%R-RNO-72737.1 Cap-dependent Translation Initiation TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE%REACTOME%R-RNO-168188.1 Toll Like Receptor TLR6:TLR2 Cascade CARBOHYDRATE METABOLISM%REACTOME DATABASE ID RELEASE 66%10144766 Carbohydrate metabolism ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS%REACTOME%R-RNO-176187.1 Activation of ATR in response to replication stress EXTRACELLULAR MATRIX ORGANIZATION%REACTOME DATABASE ID RELEASE 66%10145031 Extracellular matrix organization LEADING STRAND SYNTHESIS%REACTOME%R-RNO-69109.1 Leading Strand Synthesis REGULATED PROTEOLYSIS OF P75NTR%REACTOME DATABASE ID RELEASE 66%10145335 Regulated proteolysis of p75NTR MISMATCH REPAIR (MMR) DIRECTED BY MSH2:MSH3 (MUTSBETA)%REACTOME%R-RNO-5358606.1 Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) NEUTROPHIL DEGRANULATION%REACTOME%R-RNO-6798695.1 Neutrophil degranulation REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA%REACTOME DATABASE ID RELEASE 66%10145918 Regulation of innate immune responses to cytosolic DNA RHO GTPASES ACTIVATE CIT%REACTOME DATABASE ID RELEASE 66%10146123 RHO GTPases activate CIT FORMATION OF INCISION COMPLEX IN GG-NER%REACTOME%R-RNO-5696395.1 Formation of Incision Complex in GG-NER NTF3 ACTIVATES NTRK3 SIGNALING%REACTOME%R-RNO-9034013.1 NTF3 activates NTRK3 signaling REMOVAL OF THE FLAP INTERMEDIATE%REACTOME DATABASE ID RELEASE 66%10144734 Removal of the Flap Intermediate THE PROTON BUFFERING MODEL%REACTOME%R-RNO-167827.1 The proton buffering model POTASSIUM TRANSPORT CHANNELS%REACTOME%R-RNO-1296067.1 Potassium transport channels RUNX2 REGULATES OSTEOBLAST DIFFERENTIATION%REACTOME%R-RNO-8940973.1 RUNX2 regulates osteoblast differentiation BUTYRATE RESPONSE FACTOR 1 (BRF1) BINDS AND DESTABILIZES MRNA%REACTOME%R-RNO-450385.1 Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA NEUROTRANSMITTER CLEARANCE%REACTOME%R-RNO-112311.1 Neurotransmitter clearance RUNX3 REGULATES YAP1-MEDIATED TRANSCRIPTION%REACTOME DATABASE ID RELEASE 66%10146278 RUNX3 regulates YAP1-mediated transcription ESTABLISHMENT OF SISTER CHROMATID COHESION%REACTOME DATABASE ID RELEASE 66%10145970 Establishment of Sister Chromatid Cohesion PRC2 METHYLATES HISTONES AND DNA%REACTOME%R-RNO-212300.1 PRC2 methylates histones and DNA FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION%REACTOME%R-RNO-434316.1 Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION%REACTOME%R-RNO-381340.1 Transcriptional regulation of white adipocyte differentiation INTERLEUKIN-20 FAMILY SIGNALING%REACTOME%R-RNO-8854691.1 Interleukin-20 family signaling RHO GTPASE EFFECTORS%REACTOME DATABASE ID RELEASE 66%10144888 RHO GTPase Effectors HDL CLEARANCE%REACTOME%R-RNO-8964011.1 HDL clearance BIOSYNTHESIS OF DHA-DERIVED SPMS%REACTOME DATABASE ID RELEASE 66%10146302 Biosynthesis of DHA-derived SPMs IRS-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%R-RNO-2428928.1 IRS-related events triggered by IGF1R INSULIN RECEPTOR SIGNALLING CASCADE%REACTOME DATABASE ID RELEASE 66%10144875 Insulin receptor signalling cascade P2Y RECEPTORS%REACTOME%R-RNO-417957.1 P2Y receptors REGULATION OF ORNITHINE DECARBOXYLASE (ODC)%REACTOME DATABASE ID RELEASE 66%10145465 Regulation of ornithine decarboxylase (ODC) TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS%REACTOME%R-RNO-174417.1 Telomere C-strand (Lagging Strand) Synthesis PROTON-COUPLED MONOCARBOXYLATE TRANSPORT%REACTOME DATABASE ID RELEASE 66%10145649 Proton-coupled monocarboxylate transport INSULIN EFFECTS INCREASED SYNTHESIS OF XYLULOSE-5-PHOSPHATE%REACTOME%R-RNO-163754.1 Insulin effects increased synthesis of Xylulose-5-Phosphate TRANSPORT OF NUCLEOSIDES AND FREE PURINE AND PYRIMIDINE BASES ACROSS THE PLASMA MEMBRANE%REACTOME%R-RNO-83936.1 Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane METHYLATION%REACTOME DATABASE ID RELEASE 66%10144922 Methylation GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION%REACTOME%R-RNO-381676.1 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion CHYLOMICRON ASSEMBLY%REACTOME DATABASE ID RELEASE 66%10145238 Chylomicron assembly MYD88-INDEPENDENT TLR4 CASCADE%REACTOME%R-RNO-166166.1 MyD88-independent TLR4 cascade HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145724 Highly calcium permeable postsynaptic nicotinic acetylcholine receptors G ALPHA (12 13) SIGNALLING EVENTS%REACTOME%R-RNO-416482.1 G alpha (12 13) signalling events EPHRIN SIGNALING%REACTOME%R-RNO-3928664.1 Ephrin signaling METABOLISM OF NITRIC OXIDE%REACTOME DATABASE ID RELEASE 66%10145396 Metabolism of nitric oxide SUMOYLATION OF UBIQUITINYLATION PROTEINS%REACTOME%R-RNO-3232142.1 SUMOylation of ubiquitinylation proteins SIGNALING BY TGF-BETA RECEPTOR COMPLEX%REACTOME%R-RNO-170834.1 Signaling by TGF-beta Receptor Complex SIGNALING BY HEDGEHOG%REACTOME%R-RNO-5358351.1 Signaling by Hedgehog GABA A (RHO) RECEPTOR ACTIVATION%REACTOME DATABASE ID RELEASE 66%10145776 GABA A (rho) receptor activation SYNTHESIS OF PIPS IN THE NUCLEUS%REACTOME%R-RNO-8847453.1 Synthesis of PIPs in the nucleus TP53 REGULATES METABOLIC GENES%REACTOME DATABASE ID RELEASE 66%10144779 TP53 Regulates Metabolic Genes VLDL ASSEMBLY%REACTOME%R-RNO-8866423.1 VLDL assembly GLYCOSPHINGOLIPID METABOLISM%REACTOME%R-RNO-1660662.1 Glycosphingolipid metabolism PCP CE PATHWAY%REACTOME%R-RNO-4086400.1 PCP CE pathway OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA%REACTOME%R-RNO-1234176.1 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha OREXIN AND NEUROPEPTIDES FF AND QRFP BIND TO THEIR RESPECTIVE RECEPTORS%REACTOME%R-RNO-389397.1 Orexin and neuropeptides FF and QRFP bind to their respective receptors REGULATION OF TP53 EXPRESSION AND DEGRADATION%REACTOME%R-RNO-6806003.1 Regulation of TP53 Expression and Degradation METABOLISM OF SEROTONIN%REACTOME%R-RNO-380612.1 Metabolism of serotonin ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION%REACTOME DATABASE ID RELEASE 66%10145589 Adrenaline,noradrenaline inhibits insulin secretion DECTIN-1 MEDIATED NONCANONICAL NF-KB SIGNALING%REACTOME%R-RNO-5607761.1 Dectin-1 mediated noncanonical NF-kB signaling NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME DATABASE ID RELEASE 66%10145920 NOTCH2 Activation and Transmission of Signal to the Nucleus ESTROGEN-DEPENDENT GENE EXPRESSION%REACTOME%R-RNO-9018519.1 Estrogen-dependent gene expression TRIGLYCERIDE METABOLISM%REACTOME%R-RNO-8979227.1 Triglyceride metabolism P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME%R-RNO-372708.1 p130Cas linkage to MAPK signaling for integrins PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145719 Presynaptic nicotinic acetylcholine receptors PRE-MRNA SPLICING%REACTOME DATABASE ID RELEASE 66%10144828 pre-mRNA splicing BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS%REACTOME DATABASE ID RELEASE 66%10145554 Beta-oxidation of very long chain fatty acids PKMTS METHYLATE HISTONE LYSINES%REACTOME DATABASE ID RELEASE 66%10146041 PKMTs methylate histone lysines CHROMATIN MODIFYING ENZYMES%REACTOME%R-RNO-3247509.1 Chromatin modifying enzymes LGI-ADAM INTERACTIONS%REACTOME%R-RNO-5682910.1 LGI-ADAM interactions TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION%REACTOME DATABASE ID RELEASE 66%10145151 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7 8 or 9 activation METHIONINE SALVAGE PATHWAY%REACTOME DATABASE ID RELEASE 66%10145821 Methionine salvage pathway METABOLISM OF LIPIDS%REACTOME%R-RNO-556833.1 Metabolism of lipids INWARDLY RECTIFYING K+ CHANNELS%REACTOME DATABASE ID RELEASE 66%10145793 Inwardly rectifying K+ channels TFAP2 (AP-2) FAMILY REGULATES TRANSCRIPTION OF GROWTH FACTORS AND THEIR RECEPTORS%REACTOME%R-RNO-8866910.1 TFAP2 (AP-2) family regulates transcription of growth factors and their receptors SIGNALING BY ROBO RECEPTORS%REACTOME%R-RNO-376176.1 Signaling by ROBO receptors ORGANIC ANION TRANSPORTERS%REACTOME DATABASE ID RELEASE 66%10145484 Organic anion transporters AXONAL GROWTH INHIBITION (RHOA ACTIVATION)%REACTOME%R-RNO-193634.1 Axonal growth inhibition (RHOA activation) DOWNREGULATION OF ERBB2 SIGNALING%REACTOME%R-RNO-8863795.1 Downregulation of ERBB2 signaling ROS, RNS PRODUCTION IN PHAGOCYTES%REACTOME DATABASE ID RELEASE 66%10145602 ROS, RNS production in phagocytes GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME%R-RNO-354194.1 GRB2:SOS provides linkage to MAPK signaling for Integrins AMPLIFICATION OF SIGNAL FROM UNATTACHED KINETOCHORES VIA A MAD2 INHIBITORY SIGNAL%REACTOME DATABASE ID RELEASE 66%10145062 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal GDP-FUCOSE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 66%10145727 GDP-fucose biosynthesis REGULATION OF SIGNALING BY CBL%REACTOME%R-RNO-912631.1 Regulation of signaling by CBL CALNEXIN CALRETICULIN CYCLE%REACTOME DATABASE ID RELEASE 66%10145711 Calnexin calreticulin cycle COLLAGEN CHAIN TRIMERIZATION%REACTOME DATABASE ID RELEASE 66%10145922 Collagen chain trimerization SHC-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%R-RNO-2428933.1 SHC-related events triggered by IGF1R RAS ACTIVATION UPON CA2+ INFLUX THROUGH NMDA RECEPTOR%REACTOME%R-RNO-442982.1 Ras activation upon Ca2+ influx through NMDA receptor FRS-MEDIATED FGFR1 SIGNALING%REACTOME DATABASE ID RELEASE 66%10146102 FRS-mediated FGFR1 signaling MASTL FACILITATES MITOTIC PROGRESSION%REACTOME%R-RNO-2465910.1 MASTL Facilitates Mitotic Progression SYNTHESIS OF PE%REACTOME%R-RNO-1483213.1 Synthesis of PE INOSITOL TRANSPORTERS%REACTOME DATABASE ID RELEASE 66%10145635 Inositol transporters PHOSPHOLIPID METABOLISM%REACTOME%R-RNO-1483257.1 Phospholipid metabolism BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN%REACTOME%R-RNO-446193.1 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein BBSOME-MEDIATED CARGO-TARGETING TO CILIUM%REACTOME DATABASE ID RELEASE 66%10146078 BBSome-mediated cargo-targeting to cilium ACYL CHAIN REMODELLING OF PE%REACTOME%R-RNO-1482839.1 Acyl chain remodelling of PE RESOLUTION OF ABASIC SITES (AP SITES)%REACTOME%R-RNO-73933.1 Resolution of Abasic Sites (AP sites) ACTIVATION OF AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145580 Activation of AMPA receptors ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS%REACTOME%R-RNO-2122948.1 Activated NOTCH1 Transmits Signal to the Nucleus SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX)%REACTOME DATABASE ID RELEASE 66%10145441 Synthesis of Leukotrienes (LT) and Eoxins (EX) METABOLISM OF VITAMIN K%REACTOME%R-RNO-6806664.1 Metabolism of vitamin K OVARIAN TUMOR DOMAIN PROTEASES%REACTOME%R-RNO-5689896.1 Ovarian tumor domain proteases TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G2 CELL CYCLE ARREST%REACTOME DATABASE ID RELEASE 66%10146160 TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest EPHB-MEDIATED FORWARD SIGNALING%REACTOME DATABASE ID RELEASE 66%10146024 EPHB-mediated forward signaling APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS%REACTOME DATABASE ID RELEASE 66%10145068 APC C-mediated degradation of cell cycle proteins THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT%REACTOME DATABASE ID RELEASE 66%10144783 The citric acid (TCA) cycle and respiratory electron transport BIOTIN TRANSPORT AND METABOLISM%REACTOME DATABASE ID RELEASE 66%10145370 Biotin transport and metabolism SHC-MEDIATED CASCADE:FGFR1%REACTOME DATABASE ID RELEASE 66%10146109 SHC-mediated cascade:FGFR1 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE%REACTOME%R-RNO-77075.1 RNA Pol II CTD phosphorylation and interaction with CE AMINO ACID CONJUGATION%REACTOME DATABASE ID RELEASE 66%10145091 Amino Acid conjugation ALPHA-LINOLENIC ACID (ALA) METABOLISM%REACTOME%R-RNO-2046106.1 alpha-linolenic acid (ALA) metabolism THE PHOTOTRANSDUCTION CASCADE%REACTOME DATABASE ID RELEASE 66%10144866 The phototransduction cascade MITOCHONDRIAL FATTY ACID BETA-OXIDATION%REACTOME%R-RNO-77289.1 Mitochondrial Fatty Acid Beta-Oxidation SULFUR AMINO ACID METABOLISM%REACTOME%R-RNO-1614635.1 Sulfur amino acid metabolism NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 66%10145481 Norepinephrine Neurotransmitter Release Cycle BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145954 Binding and Uptake of Ligands by Scavenger Receptors FCERI MEDIATED CA+2 MOBILIZATION%REACTOME%R-RNO-2871809.1 FCERI mediated Ca+2 mobilization BIOSYNTHESIS OF ELECTROPHILIC Ω-3 PUFA OXO-DERIVATIVES%REACTOME DATABASE ID RELEASE 66%10146319 Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives PTEN REGULATION%REACTOME%R-RNO-6807070.1 PTEN Regulation TFAP2A ACTS AS A TRANSCRIPTIONAL REPRESSOR DURING RETINOIC ACID INDUCED CELL DIFFERENTIATION%REACTOME%R-RNO-8869496.1 TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1)%REACTOME DATABASE ID RELEASE 66%10145538 Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) TOLL LIKE RECEPTOR 4 (TLR4) CASCADE%REACTOME DATABASE ID RELEASE 66%10145130 Toll Like Receptor 4 (TLR4) Cascade ADENYLATE CYCLASE ACTIVATING PATHWAY%REACTOME DATABASE ID RELEASE 66%10145191 Adenylate cyclase activating pathway SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL%REACTOME DATABASE ID RELEASE 66%10145908 Synthesis of pyrophosphates in the cytosol NEGATIVE REGULATION OF ACTIVITY OF TFAP2 (AP-2) FAMILY TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 66%10146003 Negative regulation of activity of TFAP2 (AP-2) family transcription factors VLDL CLEARANCE%REACTOME DATABASE ID RELEASE 66%10146224 VLDL clearance RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF HSCS%REACTOME DATABASE ID RELEASE 66%10146239 RUNX1 regulates transcription of genes involved in differentiation of HSCs BIOSYNTHESIS OF DPAN-6 SPMS%REACTOME DATABASE ID RELEASE 66%10146307 Biosynthesis of DPAn-6 SPMs GROWTH HORMONE RECEPTOR SIGNALING%REACTOME DATABASE ID RELEASE 66%10145708 Growth hormone receptor signaling REUPTAKE OF GABA%REACTOME%R-RNO-888593.1 Reuptake of GABA THYROXINE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 66%10145424 Thyroxine biosynthesis PLATELET ADHESION TO EXPOSED COLLAGEN%REACTOME%R-RNO-75892.1 Platelet Adhesion to exposed collagen INITIAL TRIGGERING OF COMPLEMENT%REACTOME%R-RNO-166663.1 Initial triggering of complement FORMATION OF THE CORNIFIED ENVELOPE%REACTOME%R-RNO-6809371.1 Formation of the cornified envelope SIGNALING BY MET%REACTOME%R-RNO-6806834.1 Signaling by MET RHO GTPASES ACTIVATE FORMINS%REACTOME%R-RNO-5663220.1 RHO GTPases Activate Formins CITRIC ACID CYCLE (TCA CYCLE)%REACTOME%R-RNO-71403.1 Citric acid cycle (TCA cycle) CHAPERONIN-MEDIATED PROTEIN FOLDING%REACTOME%R-RNO-390466.1 Chaperonin-mediated protein folding KINESINS%REACTOME%R-RNO-983189.1 Kinesins SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL%REACTOME DATABASE ID RELEASE 66%10145904 Synthesis of IP3 and IP4 in the cytosol CARGO RECOGNITION FOR CLATHRIN-MEDIATED ENDOCYTOSIS%REACTOME%R-RNO-8856825.1 Cargo recognition for clathrin-mediated endocytosis ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR%REACTOME DATABASE ID RELEASE 66%10145698 Activation of Ca-permeable Kainate Receptor SIGNALING BY RHO GTPASES%REACTOME DATABASE ID RELEASE 66%10144889 Signaling by Rho GTPases OLIGOMERIZATION OF CONNEXINS INTO CONNEXONS%REACTOME DATABASE ID RELEASE 66%10145304 Oligomerization of connexins into connexons CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKK%REACTOME%R-RNO-442717.1 CREB phosphorylation through the activation of CaMKK PEPTIDE CHAIN ELONGATION%REACTOME%R-RNO-156902.1 Peptide chain elongation CLASS B 2 (SECRETIN FAMILY RECEPTORS)%REACTOME%R-RNO-373080.1 Class B 2 (Secretin family receptors) ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME DATABASE ID RELEASE 66%10145219 Activation of APC C and APC C:Cdc20 mediated degradation of mitotic proteins IRE1ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 66%10145532 IRE1alpha activates chaperones RHESUS GLYCOPROTEINS MEDIATE AMMONIUM TRANSPORT.%REACTOME DATABASE ID RELEASE 66%10145662 Rhesus glycoproteins mediate ammonium transport. RNA POLYMERASE I TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 66%10144885 RNA Polymerase I Transcription Termination APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B%REACTOME%R-RNO-174048.1 APC C:Cdc20 mediated degradation of Cyclin B MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME%REACTOME%R-RNO-975155.1 MyD88 dependent cascade initiated on endosome DSCAM INTERACTIONS%REACTOME%R-RNO-376172.1 DSCAM interactions MISCELLANEOUS TRANSPORT AND BINDING EVENTS%REACTOME%R-RNO-5223345.1 Miscellaneous transport and binding events MITOCHONDRIAL TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 66%10145117 Mitochondrial transcription initiation PINK PARKIN MEDIATED MITOPHAGY%REACTOME DATABASE ID RELEASE 66%10146045 Pink Parkin Mediated Mitophagy SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R)%REACTOME%R-RNO-2404192.1 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) INTERCONVERSION OF POLYAMINES%REACTOME DATABASE ID RELEASE 66%10145061 Interconversion of polyamines NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%R-RNO-2122947.1 NOTCH1 Intracellular Domain Regulates Transcription ELECTRIC TRANSMISSION ACROSS GAP JUNCTIONS%REACTOME DATABASE ID RELEASE 66%10145507 Electric Transmission Across Gap Junctions THE NLRP3 INFLAMMASOME%REACTOME%R-RNO-844456.1 The NLRP3 inflammasome FCGR ACTIVATION%REACTOME DATABASE ID RELEASE 66%10145910 FCGR activation SLIT2:ROBO1 INCREASES RHOA ACTIVITY%REACTOME DATABASE ID RELEASE 66%10146285 SLIT2:ROBO1 increases RHOA activity TICAM1-DEPENDENT ACTIVATION OF IRF3 IRF7%REACTOME DATABASE ID RELEASE 66%10145179 TICAM1-dependent activation of IRF3 IRF7 COX REACTIONS%REACTOME DATABASE ID RELEASE 66%10145051 COX reactions SIGNALING BY VEGF%REACTOME DATABASE ID RELEASE 66%10145273 Signaling by VEGF REGULATION OF MECP2 EXPRESSION AND ACTIVITY%REACTOME%R-RNO-9022692.1 Regulation of MECP2 expression and activity ACTIVATION OF TRKA RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145141 Activation of TRKA receptors DOWNSTREAM SIGNALING OF ACTIVATED FGFR2%REACTOME DATABASE ID RELEASE 66%10145255 Downstream signaling of activated FGFR2 VASOPRESSIN-LIKE RECEPTORS%REACTOME%R-RNO-388479.1 Vasopressin-like receptors ANCHORING OF THE BASAL BODY TO THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 66%10146081 Anchoring of the basal body to the plasma membrane ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION%REACTOME%R-RNO-2730905.1 Role of LAT2 NTAL LAB on calcium mobilization NEPHRIN FAMILY INTERACTIONS%REACTOME%R-RNO-373753.1 Nephrin family interactions IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX%REACTOME%R-RNO-937042.1 IRAK2 mediated activation of TAK1 complex PYRIMIDINE SALVAGE%REACTOME DATABASE ID RELEASE 66%10144845 Pyrimidine salvage TWIK-RELATED ALKALINE PH ACTIVATED K+ CHANNEL (TALK)%REACTOME DATABASE ID RELEASE 66%10145847 TWIK-related alkaline pH activated K+ channel (TALK) THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS)%REACTOME%R-RNO-456926.1 Thrombin signalling through proteinase activated receptors (PARs) DEADENYLATION OF MRNA%REACTOME DATABASE ID RELEASE 66%10145638 Deadenylation of mRNA FORMYL PEPTIDE RECEPTORS BIND FORMYL PEPTIDES AND MANY OTHER LIGANDS%REACTOME DATABASE ID RELEASE 66%10145663 Formyl peptide receptors bind formyl peptides and many other ligands ACTIVATION AND OLIGOMERIZATION OF BAK PROTEIN%REACTOME DATABASE ID RELEASE 66%10145015 Activation and oligomerization of BAK protein A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS%REACTOME%R-RNO-1971475.1 A tetrasaccharide linker sequence is required for GAG synthesis PKA ACTIVATION IN GLUCAGON SIGNALLING%REACTOME%R-RNO-164378.1 PKA activation in glucagon signalling CLASS C 3 (METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS)%REACTOME DATABASE ID RELEASE 66%10145488 Class C 3 (Metabotropic glutamate pheromone receptors) CA-DEPENDENT EVENTS%REACTOME DATABASE ID RELEASE 66%10144989 Ca-dependent events SUMOYLATION OF RNA BINDING PROTEINS%REACTOME DATABASE ID RELEASE 66%10146034 SUMOylation of RNA binding proteins VITAMIN B5 (PANTOTHENATE) METABOLISM%REACTOME%R-RNO-199220.1 Vitamin B5 (pantothenate) metabolism ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING%REACTOME%R-RNO-451326.1 Activation of kainate receptors upon glutamate binding TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS%REACTOME DATABASE ID RELEASE 66%10145878 Transcriptional activation of mitochondrial biogenesis DOWNSTREAM SIGNALING OF ACTIVATED FGFR1%REACTOME%R-RNO-5654687.1 Downstream signaling of activated FGFR1 TRP CHANNELS%REACTOME%R-RNO-3295583.1 TRP channels SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION%REACTOME%R-RNO-2173796.1 SMAD2 SMAD3:SMAD4 heterotrimer regulates transcription DARPP-32 EVENTS%REACTOME DATABASE ID RELEASE 66%10145005 DARPP-32 events ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON%REACTOME DATABASE ID RELEASE 66%10145137 Activation of IRF3 IRF7 mediated by TBK1 IKK epsilon GLUCAGON-TYPE LIGAND RECEPTORS%REACTOME%R-RNO-420092.1 Glucagon-type ligand receptors SUMO E3 LIGASES SUMOYLATE TARGET PROTEINS%REACTOME DATABASE ID RELEASE 66%10145992 SUMO E3 ligases SUMOylate target proteins AXON GUIDANCE%REACTOME%R-RNO-422475.1 Axon guidance SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE%REACTOME%R-RNO-416572.1 Sema4D induced cell migration and growth-cone collapse FREE FATTY ACIDS REGULATE INSULIN SECRETION%REACTOME DATABASE ID RELEASE 66%10145587 Free fatty acids regulate insulin secretion SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN%REACTOME DATABASE ID RELEASE 66%10145615 Synthesis, secretion, and deacylation of Ghrelin SIGNALING BY NOTCH3%REACTOME DATABASE ID RELEASE 66%10145952 Signaling by NOTCH3 OXYGEN-DEPENDENT ASPARAGINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA%REACTOME DATABASE ID RELEASE 66%10145810 Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha REPRODUCTION%REACTOME%R-RNO-1474165.1 Reproduction PHOSPHOLIPASE C-MEDIATED CASCADE: FGFR1%REACTOME%R-RNO-5654219.1 Phospholipase C-mediated cascade: FGFR1 MELANIN BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 66%10146119 Melanin biosynthesis DIGESTION AND ABSORPTION%REACTOME%R-RNO-8963743.1 Digestion and absorption GAP JUNCTION DEGRADATION%REACTOME DATABASE ID RELEASE 66%10145296 Gap junction degradation O-LINKED GLYCOSYLATION OF MUCINS%REACTOME%R-RNO-913709.1 O-linked glycosylation of mucins CTLA4 INHIBITORY SIGNALING%REACTOME DATABASE ID RELEASE 66%10145541 CTLA4 inhibitory signaling PENTOSE PHOSPHATE PATHWAY%REACTOME%R-RNO-71336.1 Pentose phosphate pathway UBIQUINOL BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 66%10145949 Ubiquinol biosynthesis PHASE I - FUNCTIONALIZATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 66%10144820 Phase I - Functionalization of compounds PRESYNAPTIC PHASE OF HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME DATABASE ID RELEASE 66%10146131 Presynaptic phase of homologous DNA pairing and strand exchange SLC-MEDIATED TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 66%10144952 SLC-mediated transmembrane transport ASYMMETRIC LOCALIZATION OF PCP PROTEINS%REACTOME%R-RNO-4608870.1 Asymmetric localization of PCP proteins ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12%REACTOME%R-RNO-392170.1 ADP signalling through P2Y purinoceptor 12 SIGNALING BY TGF-BETA FAMILY MEMBERS%REACTOME DATABASE ID RELEASE 66%10145195 Signaling by TGF-beta family members MITOTIC G2-G2 M PHASES%REACTOME DATABASE ID RELEASE 66%10145075 Mitotic G2-G2 M phases SIGNALLING TO ERK5%REACTOME DATABASE ID RELEASE 66%10145365 Signalling to ERK5 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS.%REACTOME%R-RNO-163200.1 Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. MYD88:MAL(TIRAP) CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME%R-RNO-166058.1 MyD88:MAL(TIRAP) cascade initiated on plasma membrane FORMATION OF THE ACTIVE COFACTOR, UDP-GLUCURONATE%REACTOME DATABASE ID RELEASE 66%10144771 Formation of the active cofactor, UDP-glucuronate GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK%REACTOME DATABASE ID RELEASE 66%10145366 Gastrin-CREB signalling pathway via PKC and MAPK INTRACELLULAR OXYGEN TRANSPORT%REACTOME%R-RNO-8981607.1 Intracellular oxygen transport NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS%REACTOME DATABASE ID RELEASE 66%10145178 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways VITAMINS B6 ACTIVATION TO PYRIDOXAL PHOSPHATE%REACTOME%R-RNO-964975.1 Vitamins B6 activation to pyridoxal phosphate SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION%REACTOME DATABASE ID RELEASE 66%10145592 Sema4D mediated inhibition of cell attachment and migration WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2%REACTOME%R-RNO-5140745.1 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME%R-RNO-110381.1 Resolution of AP sites via the single-nucleotide replacement pathway SCAVENGING BY CLASS B RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145958 Scavenging by Class B Receptors REGULATION OF TLR BY ENDOGENOUS LIGAND%REACTOME DATABASE ID RELEASE 66%10146066 Regulation of TLR by endogenous ligand NOTCH-HLH TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 66%10145446 Notch-HLH transcription pathway VITAMINS%REACTOME%R-RNO-211916.1 Vitamins UCH PROTEINASES%REACTOME DATABASE ID RELEASE 66%10146120 UCH proteinases ADRENOCEPTORS%REACTOME%R-RNO-390696.1 Adrenoceptors REGULATION OF TP53 EXPRESSION%REACTOME DATABASE ID RELEASE 66%10146179 Regulation of TP53 Expression POST-TRANSLATIONAL PROTEIN MODIFICATION%REACTOME%R-RNO-597592.1 Post-translational protein modification FGFR1B LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 66%10145285 FGFR1b ligand binding and activation HOMOLOGY DIRECTED REPAIR%REACTOME DATABASE ID RELEASE 66%10144914 Homology Directed Repair TRANSCRIPTION-COUPLED NUCLEOTIDE EXCISION REPAIR (TC-NER)%REACTOME%R-RNO-6781827.1 Transcription-Coupled Nucleotide Excision Repair (TC-NER) TRANSCRIPTIONAL REGULATION BY RUNX2%REACTOME DATABASE ID RELEASE 66%10146258 Transcriptional regulation by RUNX2 PRE-NOTCH PROCESSING IN GOLGI%REACTOME%R-RNO-1912420.1 Pre-NOTCH Processing in Golgi CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA%REACTOME DATABASE ID RELEASE 66%10145175 Cytosolic sensors of pathogen-associated DNA HDL ASSEMBLY%REACTOME DATABASE ID RELEASE 66%10145449 HDL assembly ERYTHROCYTES TAKE UP OXYGEN AND RELEASE CARBON DIOXIDE%REACTOME DATABASE ID RELEASE 66%10145820 Erythrocytes take up oxygen and release carbon dioxide REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN%REACTOME%R-RNO-1234174.1 Regulation of Hypoxia-inducible Factor (HIF) by oxygen PHASE 2 - PLATEAU PHASE%REACTOME%R-RNO-5576893.1 Phase 2 - plateau phase GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER%REACTOME%R-RNO-6782210.1 Gap-filling DNA repair synthesis and ligation in TC-NER RHO GTPASE CYCLE%REACTOME DATABASE ID RELEASE 66%10145340 Rho GTPase cycle GLUTATHIONE CONJUGATION%REACTOME%R-RNO-156590.1 Glutathione conjugation PTK6 DOWN-REGULATION%REACTOME DATABASE ID RELEASE 66%10146208 PTK6 Down-Regulation TP53 REGULATES TRANSCRIPTION OF SEVERAL ADDITIONAL CELL DEATH GENES WHOSE SPECIFIC ROLES IN P53-DEPENDENT APOPTOSIS REMAIN UNCERTAIN%REACTOME DATABASE ID RELEASE 66%10146175 TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain CYCLIN A B1 B2 ASSOCIATED EVENTS DURING G2 M TRANSITION%REACTOME%R-RNO-69273.1 Cyclin A B1 B2 associated events during G2 M transition SPHINGOLIPID METABOLISM%REACTOME%R-RNO-428157.1 Sphingolipid metabolism SPERM:OOCYTE MEMBRANE BINDING%REACTOME DATABASE ID RELEASE 66%10145840 Sperm:Oocyte Membrane Binding CRISTAE FORMATION%REACTOME%R-RNO-8949613.1 Cristae formation AROMATIC AMINES CAN BE N-HYDROXYLATED OR N-DEALKYLATED BY CYP1A2%REACTOME%R-RNO-211957.1 Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 ABACAVIR TRANSPORT AND METABOLISM%REACTOME DATABASE ID RELEASE 66%10145942 Abacavir transport and metabolism REGULATION OF CYTOSKELETAL REMODELING AND CELL SPREADING BY IPP COMPLEX COMPONENTS%REACTOME DATABASE ID RELEASE 66%10145641 Regulation of cytoskeletal remodeling and cell spreading by IPP complex components PHOSPHOLIPASE C-MEDIATED CASCADE; FGFR3%REACTOME DATABASE ID RELEASE 66%10146099 Phospholipase C-mediated cascade; FGFR3 RAF MAP KINASE CASCADE%REACTOME%R-RNO-5673001.1 RAF MAP kinase cascade ABASIC SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 66%10144981 Abasic sugar-phosphate removal via the single-nucleotide replacement pathway CRMPS IN SEMA3A SIGNALING%REACTOME%R-RNO-399956.1 CRMPs in Sema3A signaling REGULATION OF TP53 ACTIVITY THROUGH ACETYLATION%REACTOME DATABASE ID RELEASE 66%10146001 Regulation of TP53 Activity through Acetylation BIOSYNTHESIS OF MARESINS%REACTOME%R-RNO-9018682.1 Biosynthesis of maresins TP53 REGULATES TRANSCRIPTION OF CELL CYCLE GENES%REACTOME%R-RNO-6791312.1 TP53 Regulates Transcription of Cell Cycle Genes PLC BETA MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 66%10144985 PLC beta mediated events REGULATION OF EXPRESSION OF SLITS AND ROBOS%REACTOME DATABASE ID RELEASE 66%10146286 Regulation of expression of SLITs and ROBOs GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION%REACTOME DATABASE ID RELEASE 66%10145475 GABA synthesis, release, reuptake and degradation INTEGRIN ALPHAIIB BETA3 SIGNALING%REACTOME DATABASE ID RELEASE 66%10145476 Integrin alphaIIb beta3 signaling FCERI MEDIATED MAPK ACTIVATION%REACTOME DATABASE ID RELEASE 66%10145166 FCERI mediated MAPK activation PTK6 ACTIVATES STAT3%REACTOME DATABASE ID RELEASE 66%10146200 PTK6 Activates STAT3 CLEC7A INFLAMMASOME PATHWAY%REACTOME%R-RNO-5660668.1 CLEC7A inflammasome pathway SIGNALING BY NTRK1 (TRKA)%REACTOME%R-RNO-187037.1 Signaling by NTRK1 (TRKA) PEPTIDE HORMONE METABOLISM%REACTOME%R-RNO-2980736.1 Peptide hormone metabolism CELL CYCLE%REACTOME DATABASE ID RELEASE 66%10144722 Cell Cycle TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G1 CELL CYCLE ARREST%REACTOME%R-RNO-6804116.1 TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest INTERLEUKIN-2 SIGNALING%REACTOME%R-RNO-9020558.1 Interleukin-2 signaling DEPURINATION%REACTOME DATABASE ID RELEASE 66%10144975 Depurination G2 M DNA REPLICATION CHECKPOINT%REACTOME%R-RNO-69478.1 G2 M DNA replication checkpoint FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX%REACTOME DATABASE ID RELEASE 66%10145392 Formation of the beta-catenin:TCF transactivating complex ACTIVATION OF THE TFAP2 (AP-2) FAMILY OF TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 66%10146233 Activation of the TFAP2 (AP-2) family of transcription factors ATF6 (ATF6-ALPHA) ACTIVATES CHAPERONES%REACTOME%R-RNO-381033.1 ATF6 (ATF6-alpha) activates chaperones SHC-MEDIATED CASCADE:FGFR2%REACTOME%R-RNO-5654699.1 SHC-mediated cascade:FGFR2 G1 PHASE%REACTOME%R-RNO-69236.1 G1 Phase SYNTHESIS OF CL%REACTOME DATABASE ID RELEASE 66%10145873 Synthesis of CL SIGNALING BY PDGF%REACTOME DATABASE ID RELEASE 66%10145268 Signaling by PDGF SIGNALING BY FGFR%REACTOME DATABASE ID RELEASE 66%10145253 Signaling by FGFR FRS-MEDIATED FGFR3 SIGNALING%REACTOME%R-RNO-5654706.1 FRS-mediated FGFR3 signaling ACTIVATION OF DNA FRAGMENTATION FACTOR%REACTOME DATABASE ID RELEASE 66%10145439 Activation of DNA fragmentation factor CASPASE ACTIVATION VIA EXTRINSIC APOPTOTIC SIGNALLING PATHWAY%REACTOME%R-RNO-5357769.1 Caspase activation via extrinsic apoptotic signalling pathway INTERLEUKIN-21 SIGNALING%REACTOME%R-RNO-9020958.1 Interleukin-21 signaling BETA-CATENIN INDEPENDENT WNT SIGNALING%REACTOME DATABASE ID RELEASE 66%10145579 Beta-catenin independent WNT signaling PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS%REACTOME%R-RNO-73817.1 Purine ribonucleoside monophosphate biosynthesis GRB7 EVENTS IN ERBB2 SIGNALING%REACTOME%R-RNO-1306955.1 GRB7 events in ERBB2 signaling DEFENSINS%REACTOME%R-RNO-1461973.1 Defensins RUNX2 REGULATES BONE DEVELOPMENT%REACTOME DATABASE ID RELEASE 66%10146257 RUNX2 regulates bone development PROPIONYL-COA CATABOLISM%REACTOME DATABASE ID RELEASE 66%10144800 Propionyl-CoA catabolism KANDUTSCH-RUSSELL PATHWAY%REACTOME DATABASE ID RELEASE 66%10146182 Kandutsch-Russell pathway COMPLEMENT CASCADE%REACTOME%R-RNO-166658.1 Complement cascade MYD88 CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 66%10145155 MyD88 cascade initiated on plasma membrane INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS%REACTOME%R-RNO-141405.1 Inhibition of the proteolytic activity of APC C required for the onset of anaphase by mitotic spindle checkpoint components INTESTINAL HEXOSE ABSORPTION%REACTOME%R-RNO-8981373.1 Intestinal hexose absorption DOPAMINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME%R-RNO-212676.1 Dopamine Neurotransmitter Release Cycle MET ACTIVATES RAS SIGNALING%REACTOME DATABASE ID RELEASE 66%10146212 MET activates RAS signaling DAP12 SIGNALING%REACTOME DATABASE ID RELEASE 66%10145432 DAP12 signaling GAB1 SIGNALOSOME%REACTOME DATABASE ID RELEASE 66%10145248 GAB1 signalosome RIPK1-MEDIATED REGULATED NECROSIS%REACTOME%R-RNO-5213460.1 RIPK1-mediated regulated necrosis REGULATION OF PTEN GENE TRANSCRIPTION%REACTOME%R-RNO-8943724.1 Regulation of PTEN gene transcription AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1%REACTOME DATABASE ID RELEASE 66%10145450 Autodegradation of the E3 ubiquitin ligase COP1 GENE EXPRESSION (TRANSCRIPTION)%REACTOME DATABASE ID RELEASE 66%10144751 Gene expression (Transcription) MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES%REACTOME%R-RNO-450282.1 MAPK targets Nuclear events mediated by MAP kinases RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER%REACTOME%R-RNO-76071.1 RNA Polymerase III Transcription Initiation From Type 3 Promoter HSF1-DEPENDENT TRANSACTIVATION%REACTOME%R-RNO-3371571.1 HSF1-dependent transactivation DOWNSTREAM TCR SIGNALING%REACTOME DATABASE ID RELEASE 66%10145375 Downstream TCR signaling P75NTR RECRUITS SIGNALLING COMPLEXES%REACTOME%R-RNO-209543.1 p75NTR recruits signalling complexes CHOLESTEROL BIOSYNTHESIS%REACTOME%R-RNO-191273.1 Cholesterol biosynthesis MEMBRANE TRAFFICKING%REACTOME DATABASE ID RELEASE 66%10145299 Membrane Trafficking HIGHLY CALCIUM PERMEABLE NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%R-RNO-629597.1 Highly calcium permeable nicotinic acetylcholine receptors PHASE 1 - INACTIVATION OF FAST NA+ CHANNELS%REACTOME DATABASE ID RELEASE 66%10146070 Phase 1 - inactivation of fast Na+ channels TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR%REACTOME DATABASE ID RELEASE 66%10145903 Trafficking and processing of endosomal TLR INTEGRATION OF ENERGY METABOLISM%REACTOME%R-RNO-163685.1 Integration of energy metabolism INTERLEUKIN-10 SIGNALING%REACTOME DATABASE ID RELEASE 66%10145687 Interleukin-10 signaling MITOTIC ANAPHASE%REACTOME DATABASE ID RELEASE 66%10145224 Mitotic Anaphase ZINC EFFLUX AND COMPARTMENTALIZATION BY THE SLC30 FAMILY%REACTOME DATABASE ID RELEASE 66%10145653 Zinc efflux and compartmentalization by the SLC30 family GABA A RECEPTOR ACTIVATION%REACTOME%R-RNO-977441.1 GABA A receptor activation INTESTINAL ABSORPTION%REACTOME DATABASE ID RELEASE 66%10145282 Intestinal absorption DEADENYLATION-DEPENDENT MRNA DECAY%REACTOME%R-RNO-429914.1 Deadenylation-dependent mRNA decay EPH-EPHRIN MEDIATED REPULSION OF CELLS%REACTOME%R-RNO-3928665.1 EPH-ephrin mediated repulsion of cells ADRENALINE SIGNALLING THROUGH ALPHA-2 ADRENERGIC RECEPTOR%REACTOME DATABASE ID RELEASE 66%10145560 Adrenaline signalling through Alpha-2 adrenergic receptor MINERALOCORTICOID BIOSYNTHESIS%REACTOME%R-RNO-193993.1 Mineralocorticoid biosynthesis BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 66%10144858 Base Excision Repair INTERLEUKIN-2 FAMILY SIGNALING%REACTOME DATABASE ID RELEASE 66%10145686 Interleukin-2 family signaling POST-TRANSLATIONAL PROTEIN PHOSPHORYLATION%REACTOME DATABASE ID RELEASE 66%10146280 Post-translational protein phosphorylation CELLULAR RESPONSES TO STRESS%REACTOME%R-RNO-2262752.1 Cellular responses to stress RECYCLING OF BILE ACIDS AND SALTS%REACTOME%R-RNO-159418.1 Recycling of bile acids and salts METAL ION SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 66%10145650 Metal ion SLC transporters UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D%REACTOME%R-RNO-75815.1 Ubiquitin-dependent degradation of Cyclin D SIGNALING BY FGFR4%REACTOME DATABASE ID RELEASE 66%10145262 Signaling by FGFR4 SODIUM CALCIUM EXCHANGERS%REACTOME DATABASE ID RELEASE 66%10145617 Sodium Calcium exchangers POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE%REACTOME%R-RNO-174411.1 Polymerase switching on the C-strand of the telomere INTERLEUKIN RECEPTOR SHC SIGNALING%REACTOME%R-RNO-912526.1 Interleukin receptor SHC signaling REGULATION OF KIT SIGNALING%REACTOME%R-RNO-1433559.1 Regulation of KIT signaling TRAF6 MEDIATED NF-KB ACTIVATION%REACTOME%R-RNO-933542.1 TRAF6 mediated NF-kB activation REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS%REACTOME%R-RNO-450531.1 Regulation of mRNA stability by proteins that bind AU-rich elements ANDROGEN BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 66%10145322 Androgen biosynthesis ACYL CHAIN REMODELLING OF PI%REACTOME%R-RNO-1482922.1 Acyl chain remodelling of PI GLUCURONIDATION%REACTOME%R-RNO-156588.1 Glucuronidation SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS%REACTOME%R-RNO-446219.1 Synthesis of substrates in N-glycan biosythesis FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION%REACTOME%R-RNO-983231.1 Factors involved in megakaryocyte development and platelet production MRNA SPLICING%REACTOME DATABASE ID RELEASE 66%10144829 mRNA Splicing FRUCTOSE CATABOLISM%REACTOME%R-RNO-70350.1 Fructose catabolism METABOLISM OF FAT-SOLUBLE VITAMINS%REACTOME DATABASE ID RELEASE 66%10145778 Metabolism of fat-soluble vitamins NGF PROCESSING%REACTOME DATABASE ID RELEASE 66%10145269 NGF processing BETA-CATENIN PHOSPHORYLATION CASCADE%REACTOME%R-RNO-196299.1 Beta-catenin phosphorylation cascade SYNDECAN INTERACTIONS%REACTOME%R-RNO-3000170.1 Syndecan interactions MET RECEPTOR RECYCLING%REACTOME DATABASE ID RELEASE 66%10146253 MET receptor recycling IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX%REACTOME DATABASE ID RELEASE 66%10144904 Import of palmitoyl-CoA into the mitochondrial matrix COSTIMULATION BY THE CD28 FAMILY%REACTOME DATABASE ID RELEASE 66%10145355 Costimulation by the CD28 family G1 S TRANSITION%REACTOME DATABASE ID RELEASE 66%10144724 G1 S Transition PHOSPHO-PLA2 PATHWAY%REACTOME DATABASE ID RELEASE 66%10144988 phospho-PLA2 pathway NRAGE SIGNALS DEATH THROUGH JNK%REACTOME%R-RNO-193648.1 NRAGE signals death through JNK HDR THROUGH HOMOLOGOUS RECOMBINATION (HRR)%REACTOME%R-RNO-5685942.1 HDR through Homologous Recombination (HRR) N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE%REACTOME%R-RNO-532668.1 N-glycan trimming in the ER and Calnexin Calreticulin cycle IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL%REACTOME%R-RNO-198933.1 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell GAMMA-CARBOXYLATION, TRANSPORT, AND AMINO-TERMINAL CLEAVAGE OF PROTEINS%REACTOME DATABASE ID RELEASE 66%10145094 Gamma-carboxylation, transport, and amino-terminal cleavage of proteins NOTCH4 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME DATABASE ID RELEASE 66%10146329 NOTCH4 Activation and Transmission of Signal to the Nucleus PHOSPHATE BOND HYDROLYSIS BY NUDT PROTEINS%REACTOME DATABASE ID RELEASE 66%10145964 Phosphate bond hydrolysis by NUDT proteins NON-INTEGRIN MEMBRANE-ECM INTERACTIONS%REACTOME DATABASE ID RELEASE 66%10145963 Non-integrin membrane-ECM interactions MITOTIC METAPHASE ANAPHASE TRANSITION%REACTOME DATABASE ID RELEASE 66%10145108 Mitotic Metaphase Anaphase Transition CILIUM ASSEMBLY%REACTOME DATABASE ID RELEASE 66%10146080 Cilium Assembly BETA OXIDATION OF MYRISTOYL-COA TO LAUROYL-COA%REACTOME%R-RNO-77285.1 Beta oxidation of myristoyl-CoA to lauroyl-CoA CELLULAR HEXOSE TRANSPORT%REACTOME%R-RNO-189200.1 Cellular hexose transport CARGO CONCENTRATION IN THE ER%REACTOME DATABASE ID RELEASE 66%10146150 Cargo concentration in the ER BIOSYNTHESIS OF SPECIALIZED PRORESOLVING MEDIATORS (SPMS)%REACTOME%R-RNO-9018678.1 Biosynthesis of specialized proresolving mediators (SPMs) DOWNSTREAM SIGNALING OF ACTIVATED FGFR3%REACTOME%R-RNO-5654708.1 Downstream signaling of activated FGFR3 BIOSYNTHESIS OF DHA-DERIVED SULFIDO CONJUGATES%REACTOME%R-RNO-9026395.1 Biosynthesis of DHA-derived sulfido conjugates LOCALIZATION OF THE PINCH-ILK-PARVIN COMPLEX TO FOCAL ADHESIONS%REACTOME%R-RNO-446343.1 Localization of the PINCH-ILK-PARVIN complex to focal adhesions ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT)%REACTOME%R-RNO-917729.1 Endosomal Sorting Complex Required For Transport (ESCRT) MAPK3 (ERK1) ACTIVATION%REACTOME%R-RNO-110056.1 MAPK3 (ERK1) activation PEPTIDE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145486 Peptide ligand-binding receptors BIOSYNTHESIS OF EPA-DERIVED SPMS%REACTOME%R-RNO-9018679.1 Biosynthesis of EPA-derived SPMs HORMONE LIGAND-BINDING RECEPTORS%REACTOME%R-RNO-375281.1 Hormone ligand-binding receptors BIOSYNTHESIS OF DPA-DERIVED SPMS%REACTOME%R-RNO-9018683.1 Biosynthesis of DPA-derived SPMs SIGNALING BY PTK6%REACTOME%R-RNO-8848021.1 Signaling by PTK6 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%R-RNO-975144.1 IRAK1 recruits IKK complex upon TLR7 8 or 9 stimulation ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS%REACTOME%R-RNO-390471.1 Association of TriC CCT with target proteins during biosynthesis NCAM SIGNALING FOR NEURITE OUT-GROWTH%REACTOME DATABASE ID RELEASE 66%10145367 NCAM signaling for neurite out-growth DOWNSTREAM SIGNAL TRANSDUCTION%REACTOME%R-RNO-186763.1 Downstream signal transduction HDR THROUGH HOMOLOGOUS RECOMBINATION (HRR) OR SINGLE STRAND ANNEALING (SSA)%REACTOME%R-RNO-5693567.1 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) NITRIC OXIDE STIMULATES GUANYLATE CYCLASE%REACTOME DATABASE ID RELEASE 66%10145601 Nitric oxide stimulates guanylate cyclase ER QUALITY CONTROL COMPARTMENT (ERQC)%REACTOME DATABASE ID RELEASE 66%10145712 ER Quality Control Compartment (ERQC) TRAFFICKING OF AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145593 Trafficking of AMPA receptors GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE%REACTOME%R-RNO-210500.1 Glutamate Neurotransmitter Release Cycle RAP1 SIGNALLING%REACTOME DATABASE ID RELEASE 66%10145480 Rap1 signalling MISMATCH REPAIR (MMR) DIRECTED BY MSH2:MSH6 (MUTSALPHA)%REACTOME DATABASE ID RELEASE 66%10146059 Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) INTERLEUKIN-36 PATHWAY%REACTOME%R-RNO-9014826.1 Interleukin-36 pathway SYNTHESIS OF PG%REACTOME%R-RNO-1483148.1 Synthesis of PG SYNTHESIS OF PI%REACTOME%R-RNO-1483226.1 Synthesis of PI SYNTHESIS OF ACTIVE UBIQUITIN: ROLES OF E1 AND E2 ENZYMES%REACTOME DATABASE ID RELEASE 66%10146214 Synthesis of active ubiquitin: roles of E1 and E2 enzymes CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE%REACTOME%R-RNO-442720.1 CREB phosphorylation through the activation of Adenylate Cyclase TNFR1-INDUCED NFKAPPAB SIGNALING PATHWAY%REACTOME DATABASE ID RELEASE 66%10146055 TNFR1-induced NFkappaB signaling pathway BIOSYNTHESIS OF MARESIN-LIKE SPMS%REACTOME DATABASE ID RELEASE 66%10146318 Biosynthesis of maresin-like SPMs CONJUGATION OF BENZOATE WITH GLYCINE%REACTOME%R-RNO-177135.1 Conjugation of benzoate with glycine ABC-FAMILY PROTEINS MEDIATED TRANSPORT%REACTOME DATABASE ID RELEASE 66%10145462 ABC-family proteins mediated transport TRANSPORT OF GLYCEROL FROM ADIPOCYTES TO THE LIVER BY AQUAPORINS%REACTOME DATABASE ID RELEASE 66%10145643 Transport of glycerol from adipocytes to the liver by Aquaporins DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE%REACTOME%R-RNO-606279.1 Deposition of new CENPA-containing nucleosomes at the centromere INTERCONVERSION OF 2-OXOGLUTARATE AND 2-HYDROXYGLUTARATE%REACTOME%R-RNO-880009.1 Interconversion of 2-oxoglutarate and 2-hydroxyglutarate HS-GAG DEGRADATION%REACTOME%R-RNO-2024096.1 HS-GAG degradation GABA B RECEPTOR ACTIVATION%REACTOME%R-RNO-977444.1 GABA B receptor activation GLYCEROPHOSPHOLIPID CATABOLISM%REACTOME DATABASE ID RELEASE 66%10146195 Glycerophospholipid catabolism PI3K AKT SIGNALING%REACTOME%R-RNO-1257604.1 PI3K AKT Signaling SUMOYLATION OF TRANSCRIPTION FACTORS%REACTOME%R-RNO-3232118.1 SUMOylation of transcription factors M PHASE%REACTOME%R-RNO-68886.1 M Phase ACTIVATION OF BID AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%R-RNO-75108.1 Activation of BID and translocation to mitochondria FGFR1C AND KLOTHO LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 66%10145295 FGFR1c and Klotho ligand binding and activation INTRAFLAGELLAR TRANSPORT%REACTOME%R-RNO-5620924.1 Intraflagellar transport BETA OXIDATION OF PALMITOYL-COA TO MYRISTOYL-COA%REACTOME DATABASE ID RELEASE 66%10144934 Beta oxidation of palmitoyl-CoA to myristoyl-CoA SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE%REACTOME DATABASE ID RELEASE 66%10145902 Synthesis of PIPs at the early endosome membrane RNA POLYMERASE II TRANSCRIPTION ELONGATION%REACTOME%R-RNO-75955.1 RNA Polymerase II Transcription Elongation TOLL LIKE RECEPTOR 5 (TLR5) CASCADE%REACTOME DATABASE ID RELEASE 66%10145157 Toll Like Receptor 5 (TLR5) Cascade GLUCOCORTICOID BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 66%10145323 Glucocorticoid biosynthesis REACTIONS SPECIFIC TO THE COMPLEX N-GLYCAN SYNTHESIS PATHWAY%REACTOME DATABASE ID RELEASE 66%10145779 Reactions specific to the complex N-glycan synthesis pathway SIGNALING BY INTERLEUKINS%REACTOME DATABASE ID RELEASE 66%10145163 Signaling by Interleukins DETOXIFICATION OF REACTIVE OXYGEN SPECIES%REACTOME%R-RNO-3299685.1 Detoxification of Reactive Oxygen Species PLASMA LIPOPROTEIN CLEARANCE%REACTOME%R-RNO-8964043.1 Plasma lipoprotein clearance PEROXISOMAL LIPID METABOLISM%REACTOME%R-RNO-390918.1 Peroxisomal lipid metabolism GAP JUNCTION ASSEMBLY%REACTOME%R-RNO-190861.1 Gap junction assembly DNA DAMAGE RECOGNITION IN GG-NER%REACTOME DATABASE ID RELEASE 66%10146144 DNA Damage Recognition in GG-NER MITOTIC METAPHASE AND ANAPHASE%REACTOME DATABASE ID RELEASE 66%10145109 Mitotic Metaphase and Anaphase POST NMDA RECEPTOR ACTIVATION EVENTS%REACTOME%R-RNO-438064.1 Post NMDA receptor activation events MAP KINASE ACTIVATION%REACTOME DATABASE ID RELEASE 66%10145160 MAP kinase activation NUCLEOBASE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 66%10144842 Nucleobase biosynthesis MITOCHONDRIAL TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 66%10145689 Mitochondrial tRNA aminoacylation PI3K AKT ACTIVATION%REACTOME DATABASE ID RELEASE 66%10145352 PI3K AKT activation PTK6 REGULATES PROTEINS INVOLVED IN RNA PROCESSING%REACTOME DATABASE ID RELEASE 66%10146207 PTK6 Regulates Proteins Involved in RNA Processing CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE%REACTOME%R-RNO-204998.1 Cell death signalling via NRAGE, NRIF and NADE SELENOAMINO ACID METABOLISM%REACTOME%R-RNO-2408522.1 Selenoamino acid metabolism CELL CYCLE CHECKPOINTS%REACTOME DATABASE ID RELEASE 66%10144741 Cell Cycle Checkpoints NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC)%REACTOME%R-RNO-975957.1 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) INTERLEUKIN-18 SIGNALING%REACTOME%R-RNO-9012546.1 Interleukin-18 signaling FRS-MEDIATED FGFR2 SIGNALING%REACTOME DATABASE ID RELEASE 66%10146103 FRS-mediated FGFR2 signaling BASE-EXCISION REPAIR, AP SITE FORMATION%REACTOME%R-RNO-73929.1 Base-Excision Repair, AP Site Formation RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER%REACTOME DATABASE ID RELEASE 66%10144947 RNA Polymerase III Transcription Initiation From Type 2 Promoter CYP2E1 REACTIONS%REACTOME%R-RNO-211999.1 CYP2E1 reactions TRANSLATION INITIATION COMPLEX FORMATION%REACTOME DATABASE ID RELEASE 66%10145076 Translation initiation complex formation UNBLOCKING OF NMDA RECEPTORS, GLUTAMATE BINDING AND ACTIVATION%REACTOME%R-RNO-438066.1 Unblocking of NMDA receptors, glutamate binding and activation CAMK IV-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%R-RNO-111932.1 CaMK IV-mediated phosphorylation of CREB LYSOSPHINGOLIPID AND LPA RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145608 Lysosphingolipid and LPA receptors METABOLISM OF INGESTED SEMET, SEC, MESEC INTO H2SE%REACTOME%R-RNO-2408508.1 Metabolism of ingested SeMet, Sec, MeSec into H2Se GLYCOSAMINOGLYCAN METABOLISM%REACTOME%R-RNO-1630316.1 Glycosaminoglycan metabolism RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 66%10144983 Resolution of AP sites via the multiple-nucleotide patch replacement pathway IGF1R SIGNALING CASCADE%REACTOME%R-RNO-2428924.1 IGF1R signaling cascade CELLULAR RESPONSES TO EXTERNAL STIMULI%REACTOME%R-RNO-8953897.1 Cellular responses to external stimuli CHYLOMICRON CLEARANCE%REACTOME%R-RNO-8964026.1 Chylomicron clearance HIGHLY SODIUM PERMEABLE ACETYLCHOLINE NICOTINIC RECEPTORS%REACTOME%R-RNO-629587.1 Highly sodium permeable acetylcholine nicotinic receptors NEGATIVE REGULATION OF MAPK PATHWAY%REACTOME%R-RNO-5675221.1 Negative regulation of MAPK pathway SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE%REACTOME DATABASE ID RELEASE 66%10145899 Synthesis of PIPs at the late endosome membrane ACETYLCHOLINE REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 66%10145585 Acetylcholine regulates insulin secretion RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS%REACTOME%R-RNO-674695.1 RNA Polymerase II Pre-transcription Events REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA)%REACTOME DATABASE ID RELEASE 66%10145590 Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) CONJUGATION OF SALICYLATE WITH GLYCINE%REACTOME%R-RNO-177128.1 Conjugation of salicylate with glycine CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY%REACTOME DATABASE ID RELEASE 66%10145212 Cyclin A:Cdk2-associated events at S phase entry NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 66%10145513 Nuclear Receptor transcription pathway AURKA ACTIVATION BY TPX2%REACTOME%R-RNO-8854518.1 AURKA Activation by TPX2 FATTY ACIDS%REACTOME%R-RNO-211935.1 Fatty acids MITOTIC PROPHASE%REACTOME DATABASE ID RELEASE 66%10145525 Mitotic Prophase THE RETINOID CYCLE IN CONES (DAYLIGHT VISION)%REACTOME DATABASE ID RELEASE 66%10145969 The retinoid cycle in cones (daylight vision) TERMINATION OF O-GLYCAN BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 66%10145784 Termination of O-glycan biosynthesis GLYCOGEN METABOLISM%REACTOME DATABASE ID RELEASE 66%10144770 Glycogen metabolism INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES%REACTOME%R-RNO-499943.1 Interconversion of nucleotide di- and triphosphates N-GLYCAN ANTENNAE ELONGATION%REACTOME DATABASE ID RELEASE 66%10145781 N-Glycan antennae elongation O-LINKED GLYCOSYLATION%REACTOME%R-RNO-5173105.1 O-linked glycosylation DNA REPLICATION INITIATION%REACTOME DATABASE ID RELEASE 66%10144718 DNA replication initiation PURINE SALVAGE%REACTOME DATABASE ID RELEASE 66%10144873 Purine salvage G-PROTEIN BETA:GAMMA SIGNALLING%REACTOME%R-RNO-397795.1 G-protein beta:gamma signalling ALTERNATIVE COMPLEMENT ACTIVATION%REACTOME DATABASE ID RELEASE 66%10145211 Alternative complement activation SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP)%REACTOME DATABASE ID RELEASE 66%10145264 Senescence-Associated Secretory Phenotype (SASP) SIGNALING BY INSULIN RECEPTOR%REACTOME%R-RNO-74752.1 Signaling by Insulin receptor SIGNALING BY NODAL%REACTOME%R-RNO-1181150.1 Signaling by NODAL PI3K EVENTS IN ERBB2 SIGNALING%REACTOME DATABASE ID RELEASE 66%10145823 PI3K events in ERBB2 signaling U12 DEPENDENT SPLICING%REACTOME%R-RNO-72165.1 U12 Dependent Splicing RHO GTPASES ACTIVATE PKNS%REACTOME%R-RNO-5625740.1 RHO GTPases activate PKNs C6 DEAMINATION OF ADENOSINE%REACTOME%R-RNO-75102.1 C6 deamination of adenosine SERINE BIOSYNTHESIS%REACTOME%R-RNO-977347.1 Serine biosynthesis NEGATIVE REGULATION OF THE PI3K AKT NETWORK%REACTOME%R-RNO-199418.1 Negative regulation of the PI3K AKT network METABOLISM OF FOLATE AND PTERINES%REACTOME%R-RNO-196757.1 Metabolism of folate and pterines ACTIVATION OF C3 AND C5%REACTOME%R-RNO-174577.1 Activation of C3 and C5 SHC-MEDIATED CASCADE:FGFR3%REACTOME%R-RNO-5654704.1 SHC-mediated cascade:FGFR3 BIOLOGICAL OXIDATIONS%REACTOME%R-RNO-211859.1 Biological oxidations NONCANONICAL ACTIVATION OF NOTCH3%REACTOME%R-RNO-9017802.1 Noncanonical activation of NOTCH3 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION)%REACTOME%R-RNO-2453902.1 The canonical retinoid cycle in rods (twilight vision) REGULATION OF TNFR1 SIGNALING%REACTOME DATABASE ID RELEASE 66%10146056 Regulation of TNFR1 signaling RNA POLYMERASE II PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 66%10144902 RNA Polymerase II Promoter Escape SUMOYLATION OF DNA METHYLATION PROTEINS%REACTOME%R-RNO-4655427.1 SUMOylation of DNA methylation proteins RUNX1 REGULATES ESTROGEN RECEPTOR MEDIATED TRANSCRIPTION%REACTOME DATABASE ID RELEASE 66%10146262 RUNX1 regulates estrogen receptor mediated transcription THREONINE CATABOLISM%REACTOME DATABASE ID RELEASE 66%10146296 Threonine catabolism METABOLISM OF RNA%REACTOME DATABASE ID RELEASE 66%10144827 Metabolism of RNA SYNTHESIS OF DOLICHYL-PHOSPHATE MANNOSE%REACTOME DATABASE ID RELEASE 66%10145103 Synthesis of dolichyl-phosphate mannose RNA POLYMERASE III TRANSCRIPTION INITIATION%REACTOME%R-RNO-76046.1 RNA Polymerase III Transcription Initiation ADENOSINE P1 RECEPTORS%REACTOME%R-RNO-417973.1 Adenosine P1 receptors WAX BIOSYNTHESIS%REACTOME%R-RNO-8848584.1 Wax biosynthesis ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 66%10145451 Acetylcholine Neurotransmitter Release Cycle TRAIL SIGNALING%REACTOME%R-RNO-75158.1 TRAIL signaling DIGESTION%REACTOME DATABASE ID RELEASE 66%10145278 Digestion CELLULAR SENESCENCE%REACTOME%R-RNO-2559583.1 Cellular Senescence G ALPHA (S) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 66%10145517 G alpha (s) signalling events TNFR1-MEDIATED CERAMIDE PRODUCTION%REACTOME DATABASE ID RELEASE 66%10146089 TNFR1-mediated ceramide production SIGNALING BY RETINOIC ACID%REACTOME DATABASE ID RELEASE 66%10145381 Signaling by Retinoic Acid DIMERIZATION OF PROCASPASE-8%REACTOME%R-RNO-69416.1 Dimerization of procaspase-8 REGULATION OF GAP JUNCTION ACTIVITY%REACTOME DATABASE ID RELEASE 66%10145308 Regulation of gap junction activity PROLONGED ERK ACTIVATION EVENTS%REACTOME DATABASE ID RELEASE 66%10145181 Prolonged ERK activation events RELEASE OF APOPTOTIC FACTORS FROM THE MITOCHONDRIA%REACTOME DATABASE ID RELEASE 66%10145018 Release of apoptotic factors from the mitochondria SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE%REACTOME%R-RNO-1660499.1 Synthesis of PIPs at the plasma membrane TRANSPORT AND SYNTHESIS OF PAPS%REACTOME%R-RNO-174362.1 Transport and synthesis of PAPS DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING%REACTOME DATABASE ID RELEASE 66%10145207 Downregulation of TGF-beta receptor signaling SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI)%REACTOME%R-RNO-162710.1 Synthesis of glycosylphosphatidylinositol (GPI) INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS%REACTOME%R-RNO-997272.1 Inhibition of voltage gated Ca2+ channels via Gbeta gamma subunits PROTON-COUPLED NEUTRAL AMINO ACID TRANSPORTERS%REACTOME DATABASE ID RELEASE 66%10145510 Proton-coupled neutral amino acid transporters ERYTHROPOIETIN ACTIVATES PHOSPHOINOSITIDE-3-KINASE (PI3K)%REACTOME DATABASE ID RELEASE 66%10146294 Erythropoietin activates Phosphoinositide-3-kinase (PI3K) METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS%REACTOME DATABASE ID RELEASE 66%10145925 Metabolism of Angiotensinogen to Angiotensins ION CHANNEL TRANSPORT%REACTOME DATABASE ID RELEASE 66%10145600 Ion channel transport CREB3 FACTORS ACTIVATE GENES%REACTOME DATABASE ID RELEASE 66%10146248 CREB3 factors activate genes ORC1 REMOVAL FROM CHROMATIN%REACTOME%R-RNO-68949.1 Orc1 removal from chromatin SIGNALING BY FGFR2%REACTOME DATABASE ID RELEASE 66%10145256 Signaling by FGFR2 AMINE OXIDASE REACTIONS%REACTOME DATABASE ID RELEASE 66%10145056 Amine Oxidase reactions TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION%REACTOME%R-RNO-948021.1 Transport to the Golgi and subsequent modification L1CAM INTERACTIONS%REACTOME DATABASE ID RELEASE 66%10144965 L1CAM interactions PROLACTIN RECEPTOR SIGNALING%REACTOME DATABASE ID RELEASE 66%10145783 Prolactin receptor signaling ACETYLATION%REACTOME DATABASE ID RELEASE 66%10145083 Acetylation CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII%REACTOME DATABASE ID RELEASE 66%10145658 CREB phosphorylation through the activation of CaMKII FORMATION OF XYLULOSE-5-PHOSPHATE%REACTOME DATABASE ID RELEASE 66%10146116 Formation of xylulose-5-phosphate BETA DEFENSINS%REACTOME DATABASE ID RELEASE 66%10145858 Beta defensins GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY%REACTOME%R-RNO-399721.1 Glutamate binding, activation of AMPA receptors and synaptic plasticity STRIATED MUSCLE CONTRACTION%REACTOME%R-RNO-390522.1 Striated Muscle Contraction ABC TRANSPORTERS IN LIPID HOMEOSTASIS%REACTOME DATABASE ID RELEASE 66%10145461 ABC transporters in lipid homeostasis RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF MYELOID CELLS%REACTOME DATABASE ID RELEASE 66%10146266 RUNX1 regulates transcription of genes involved in differentiation of myeloid cells ESR-MEDIATED SIGNALING%REACTOME DATABASE ID RELEASE 66%10145830 ESR-mediated signaling G ALPHA (Q) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 66%10145036 G alpha (q) signalling events PI3K EVENTS IN ERBB4 SIGNALING%REACTOME%R-RNO-1250342.1 PI3K events in ERBB4 signaling CGMP EFFECTS%REACTOME%R-RNO-418457.1 cGMP effects INTERACTION BETWEEN PHLDA1 AND AURKA%REACTOME DATABASE ID RELEASE 66%10146219 Interaction between PHLDA1 and AURKA G-PROTEIN MEDIATED EVENTS%REACTOME%R-RNO-112040.1 G-protein mediated events ERBB2 REGULATES CELL MOTILITY%REACTOME DATABASE ID RELEASE 66%10146156 ERBB2 Regulates Cell Motility S PHASE%REACTOME%R-RNO-69242.1 S Phase IL-6-TYPE CYTOKINE RECEPTOR LIGAND INTERACTIONS%REACTOME DATABASE ID RELEASE 66%10145682 IL-6-type cytokine receptor ligand interactions VESICLE-MEDIATED TRANSPORT%REACTOME DATABASE ID RELEASE 66%10145300 Vesicle-mediated transport CONJUGATION OF PHENYLACETATE WITH GLUTAMINE%REACTOME DATABASE ID RELEASE 66%10145246 Conjugation of phenylacetate with glutamine SIGNALING BY FGFR1%REACTOME%R-RNO-5654736.1 Signaling by FGFR1 RNA POLYMERASE I CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 66%10144884 RNA Polymerase I Chain Elongation INTERLEUKIN-17 SIGNALING%REACTOME%R-RNO-448424.1 Interleukin-17 signaling HDMS DEMETHYLATE HISTONES%REACTOME DATABASE ID RELEASE 66%10145998 HDMs demethylate histones RNA POLYMERASE I TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 66%10144850 RNA Polymerase I Transcription Initiation SCAVENGING OF HEME FROM PLASMA%REACTOME%R-RNO-2168880.1 Scavenging of heme from plasma MAP3K8 (TPL2)-DEPENDENT MAPK1 3 ACTIVATION%REACTOME DATABASE ID RELEASE 66%10145702 MAP3K8 (TPL2)-dependent MAPK1 3 activation SYNTHESIS OF 5-EICOSATETRAENOIC ACIDS%REACTOME%R-RNO-2142688.1 Synthesis of 5-eicosatetraenoic acids MYOGENESIS%REACTOME%R-RNO-525793.1 Myogenesis CHONDROITIN SULFATE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 66%10145919 Chondroitin sulfate biosynthesis SIGNALING BY LEPTIN%REACTOME DATABASE ID RELEASE 66%10145709 Signaling by Leptin ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1%REACTOME DATABASE ID RELEASE 66%10145597 ADP signalling through P2Y purinoceptor 1 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE%REACTOME%R-RNO-2559586.1 DNA Damage Telomere Stress Induced Senescence FATTY ACYL-COA BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 66%10144901 Fatty acyl-CoA biosynthesis P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME%R-RNO-69580.1 p53-Dependent G1 S DNA damage checkpoint RSK ACTIVATION%REACTOME DATABASE ID RELEASE 66%10145660 RSK activation PROCESSING OF CAPPED INTRONLESS PRE-MRNA%REACTOME%R-RNO-75067.1 Processing of Capped Intronless Pre-mRNA DUAL INCISION IN GG-NER%REACTOME DATABASE ID RELEASE 66%10146140 Dual Incision in GG-NER CONDENSATION OF PROPHASE CHROMOSOMES%REACTOME DATABASE ID RELEASE 66%10145955 Condensation of Prophase Chromosomes REGULATION OF TP53 ACTIVITY%REACTOME%R-RNO-5633007.1 Regulation of TP53 Activity MICROTUBULE-DEPENDENT TRAFFICKING OF CONNEXONS FROM GOLGI TO THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 66%10145301 Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane ER TO GOLGI ANTEROGRADE TRANSPORT%REACTOME%R-RNO-199977.1 ER to Golgi Anterograde Transport IRON UPTAKE AND TRANSPORT%REACTOME DATABASE ID RELEASE 66%10145283 Iron uptake and transport CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION%REACTOME DATABASE ID RELEASE 66%10145415 Class I MHC mediated antigen processing & presentation POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%R-RNO-622327.1 Postsynaptic nicotinic acetylcholine receptors INTERLEUKIN-15 SIGNALING%REACTOME%R-RNO-8983432.1 Interleukin-15 signaling CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE%REACTOME%R-RNO-176407.1 Conversion from APC C:Cdc20 to APC C:Cdh1 in late anaphase ACTIVATED NTRK2 SIGNALS THROUGH FYN%REACTOME DATABASE ID RELEASE 66%10146323 Activated NTRK2 signals through FYN MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF SATURATED FATTY ACIDS%REACTOME%R-RNO-77286.1 mitochondrial fatty acid beta-oxidation of saturated fatty acids MET ACTIVATES RAP1 AND RAC1%REACTOME DATABASE ID RELEASE 66%10146252 MET activates RAP1 and RAC1 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION%REACTOME%R-RNO-156827.1 L13a-mediated translational silencing of Ceruloplasmin expression HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME%R-RNO-5693579.1 Homologous DNA Pairing and Strand Exchange P75NTR SIGNALS VIA NF-KB%REACTOME%R-RNO-193639.1 p75NTR signals via NF-kB CELL-CELL COMMUNICATION%REACTOME DATABASE ID RELEASE 66%10145431 Cell-Cell communication RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASES%REACTOME DATABASE ID RELEASE 66%10145543 Receptor-type tyrosine-protein phosphatases SULFIDE OXIDATION TO SULFATE%REACTOME DATABASE ID RELEASE 66%10145889 Sulfide oxidation to sulfate SIGNALING BY EGFR%REACTOME DATABASE ID RELEASE 66%10144957 Signaling by EGFR INVADOPODIA FORMATION%REACTOME DATABASE ID RELEASE 66%10146271 Invadopodia formation P53-DEPENDENT G1 DNA DAMAGE RESPONSE%REACTOME%R-RNO-69563.1 p53-Dependent G1 DNA Damage Response METAL SEQUESTRATION BY ANTIMICROBIAL PROTEINS%REACTOME DATABASE ID RELEASE 66%10145804 Metal sequestration by antimicrobial proteins SUMOYLATION OF IMMUNE RESPONSE PROTEINS%REACTOME%R-RNO-4755510.1 SUMOylation of immune response proteins LYSINE CATABOLISM%REACTOME%R-RNO-71064.1 Lysine catabolism ARL13B-MEDIATED CILIARY TRAFFICKING OF INPP5E%REACTOME DATABASE ID RELEASE 66%10146085 ARL13B-mediated ciliary trafficking of INPP5E TRANSPORT OF FATTY ACIDS%REACTOME%R-RNO-804914.1 Transport of fatty acids COPI-DEPENDENT GOLGI-TO-ER RETROGRADE TRAFFIC%REACTOME%R-RNO-6811434.1 COPI-dependent Golgi-to-ER retrograde traffic METABOLISM OF PROTEINS%REACTOME DATABASE ID RELEASE 66%10144825 Metabolism of proteins IRF3-MEDIATED INDUCTION OF TYPE I IFN%REACTOME DATABASE ID RELEASE 66%10145930 IRF3-mediated induction of type I IFN REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION%REACTOME%R-RNO-2565942.1 Regulation of PLK1 Activity at G2 M Transition INTERLEUKIN-33 SIGNALING%REACTOME%R-RNO-9014843.1 Interleukin-33 signaling MHC CLASS II ANTIGEN PRESENTATION%REACTOME DATABASE ID RELEASE 66%10145936 MHC class II antigen presentation DNA REPLICATION%REACTOME%R-RNO-69306.1 DNA Replication ARYL HYDROCARBON RECEPTOR SIGNALLING%REACTOME DATABASE ID RELEASE 66%10146264 Aryl hydrocarbon receptor signalling ISG15 ANTIVIRAL MECHANISM%REACTOME DATABASE ID RELEASE 66%10145800 ISG15 antiviral mechanism GENERIC TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 66%10144749 Generic Transcription Pathway ACYL CHAIN REMODELING OF CL%REACTOME%R-RNO-1482798.1 Acyl chain remodeling of CL VOLTAGE GATED POTASSIUM CHANNELS%REACTOME DATABASE ID RELEASE 66%10145837 Voltage gated Potassium channels ADHERENS JUNCTIONS INTERACTIONS%REACTOME DATABASE ID RELEASE 66%10145606 Adherens junctions interactions BETA-OXIDATION OF PRISTANOYL-COA%REACTOME%R-RNO-389887.1 Beta-oxidation of pristanoyl-CoA SEMA4D IN SEMAPHORIN SIGNALING%REACTOME%R-RNO-400685.1 Sema4D in semaphorin signaling TRANSCRIPTIONAL REGULATION BY E2F6%REACTOME%R-RNO-8953750.1 Transcriptional Regulation by E2F6 SUMOYLATION OF DNA DAMAGE RESPONSE AND REPAIR PROTEINS%REACTOME%R-RNO-3108214.1 SUMOylation of DNA damage response and repair proteins ERK1 ERK2 PATHWAY%REACTOME DATABASE ID RELEASE 66%10144961 ERK1 ERK2 pathway TOLL LIKE RECEPTOR 9 (TLR9) CASCADE%REACTOME DATABASE ID RELEASE 66%10145153 Toll Like Receptor 9 (TLR9) Cascade GLUCAGON SIGNALING IN METABOLIC REGULATION%REACTOME DATABASE ID RELEASE 66%10145003 Glucagon signaling in metabolic regulation ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION%REACTOME DATABASE ID RELEASE 66%10145786 Antigen processing: Ubiquitination & Proteasome degradation GAP JUNCTION TRAFFICKING%REACTOME%R-RNO-190828.1 Gap junction trafficking REGULATION OF PTEN STABILITY AND ACTIVITY%REACTOME DATABASE ID RELEASE 66%10146185 Regulation of PTEN stability and activity EXTRINSIC PATHWAY OF FIBRIN CLOT FORMATION%REACTOME DATABASE ID RELEASE 66%10145054 Extrinsic Pathway of Fibrin Clot Formation MITOCHONDRIAL TRANSLATION ELONGATION%REACTOME DATABASE ID RELEASE 66%10146063 Mitochondrial translation elongation TRANSFER OF LPS FROM LBP CARRIER TO CD14%REACTOME%R-RNO-166020.1 Transfer of LPS from LBP carrier to CD14 ENOS ACTIVATION AND REGULATION%REACTOME%R-RNO-203765.1 eNOS activation and regulation G2 M TRANSITION%REACTOME%R-RNO-69275.1 G2 M Transition SYNTHESIS OF GDP-MANNOSE%REACTOME DATABASE ID RELEASE 66%10145672 Synthesis of GDP-mannose PI-3K CASCADE:FGFR3%REACTOME DATABASE ID RELEASE 66%10145257 PI-3K cascade:FGFR3 PAOS OXIDISE POLYAMINES TO AMINES%REACTOME DATABASE ID RELEASE 66%10145060 PAOs oxidise polyamines to amines DOWNREGULATION OF ERBB4 SIGNALING%REACTOME DATABASE ID RELEASE 66%10145828 Downregulation of ERBB4 signaling REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION%REACTOME%R-RNO-2029482.1 Regulation of actin dynamics for phagocytic cup formation TERMINAL PATHWAY OF COMPLEMENT%REACTOME DATABASE ID RELEASE 66%10145210 Terminal pathway of complement REGULATION OF RUNX1 EXPRESSION AND ACTIVITY%REACTOME%R-RNO-8934593.1 Regulation of RUNX1 Expression and Activity INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%R-RNO-2514859.1 Inactivation, recovery and regulation of the phototransduction cascade GENERATION OF SECOND MESSENGER MOLECULES%REACTOME DATABASE ID RELEASE 66%10145400 Generation of second messenger molecules MITOCHONDRIAL TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 66%10145119 Mitochondrial transcription termination CLEAVAGE OF THE DAMAGED PYRIMIDINE%REACTOME%R-RNO-110329.1 Cleavage of the damaged pyrimidine INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME DATABASE ID RELEASE 66%10145016 Intrinsic Pathway for Apoptosis PHASE 3 - RAPID REPOLARISATION%REACTOME%R-RNO-5576890.1 Phase 3 - rapid repolarisation TRANSLESION SYNTHESIS BY POLH%REACTOME%R-RNO-110320.1 Translesion Synthesis by POLH PLATELET CALCIUM HOMEOSTASIS%REACTOME%R-RNO-418360.1 Platelet calcium homeostasis NUCLEAR ENVELOPE REASSEMBLY%REACTOME%R-RNO-2995410.1 Nuclear Envelope Reassembly DAG AND IP3 SIGNALING%REACTOME%R-RNO-1489509.1 DAG and IP3 signaling ION INFLUX EFFLUX AT HOST-PATHOGEN INTERFACE%REACTOME%R-RNO-6803544.1 Ion influx efflux at host-pathogen interface GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER%REACTOME DATABASE ID RELEASE 66%10146143 Gap-filling DNA repair synthesis and ligation in GG-NER PYRIMIDINE CATABOLISM%REACTOME%R-RNO-73621.1 Pyrimidine catabolism GLYCOLYSIS%REACTOME DATABASE ID RELEASE 66%10144768 Glycolysis MOLECULES ASSOCIATED WITH ELASTIC FIBRES%REACTOME DATABASE ID RELEASE 66%10145882 Molecules associated with elastic fibres OXIDATIVE DEMETHYLATION OF DNA%REACTOME DATABASE ID RELEASE 66%10146048 Oxidative demethylation of DNA TRANSPORT OF CONNEXONS TO THE PLASMA MEMBRANE%REACTOME%R-RNO-190872.1 Transport of connexons to the plasma membrane RRNA PROCESSING%REACTOME DATABASE ID RELEASE 66%10146163 rRNA processing AGMATINE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 66%10145466 Agmatine biosynthesis MUSCARINIC ACETYLCHOLINE RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145559 Muscarinic acetylcholine receptors ACTIVATED NTRK2 SIGNALS THROUGH PLCG1%REACTOME%R-RNO-9026527.1 Activated NTRK2 signals through PLCG1 KETONE BODY METABOLISM%REACTOME DATABASE ID RELEASE 66%10144854 Ketone body metabolism TYPE II NA+ PI COTRANSPORTERS%REACTOME DATABASE ID RELEASE 66%10145628 Type II Na+ Pi cotransporters TRAF3-DEPENDENT IRF ACTIVATION PATHWAY%REACTOME DATABASE ID RELEASE 66%10145795 TRAF3-dependent IRF activation pathway ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX%REACTOME%R-RNO-68867.1 Assembly of the pre-replicative complex SYNTHESIS OF PC%REACTOME DATABASE ID RELEASE 66%10145452 Synthesis of PC HYALURONAN UPTAKE AND DEGRADATION%REACTOME%R-RNO-2160916.1 Hyaluronan uptake and degradation SIGNALING BY NOTCH1%REACTOME DATABASE ID RELEASE 66%10145913 Signaling by NOTCH1 PASSIVE TRANSPORT BY AQUAPORINS%REACTOME DATABASE ID RELEASE 66%10145707 Passive transport by Aquaporins NCAM1 INTERACTIONS%REACTOME DATABASE ID RELEASE 66%10145505 NCAM1 interactions SIALIC ACID METABOLISM%REACTOME DATABASE ID RELEASE 66%10145633 Sialic acid metabolism G1 S DNA DAMAGE CHECKPOINTS%REACTOME DATABASE ID RELEASE 66%10144740 G1 S DNA Damage Checkpoints SODIUM-COUPLED PHOSPHATE COTRANSPORTERS%REACTOME DATABASE ID RELEASE 66%10145627 Sodium-coupled phosphate cotransporters REGULATION OF COMMISSURAL AXON PATHFINDING BY SLIT AND ROBO%REACTOME DATABASE ID RELEASE 66%10145632 Regulation of commissural axon pathfinding by SLIT and ROBO REGULATION OF PTEN LOCALIZATION%REACTOME%R-RNO-8948747.1 Regulation of PTEN localization PHASE II - CONJUGATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 66%10144773 Phase II - Conjugation of compounds TRANSFERRIN ENDOCYTOSIS AND RECYCLING%REACTOME%R-RNO-917977.1 Transferrin endocytosis and recycling NECTIN NECL TRANS HETERODIMERIZATION%REACTOME DATABASE ID RELEASE 66%10145613 Nectin Necl trans heterodimerization REGULATION OF FZD BY UBIQUITINATION%REACTOME DATABASE ID RELEASE 66%10146037 Regulation of FZD by ubiquitination FGFR3B LIGAND BINDING AND ACTIVATION%REACTOME%R-RNO-190371.1 FGFR3b ligand binding and activation ION HOMEOSTASIS%REACTOME DATABASE ID RELEASE 66%10145041 Ion homeostasis DEVELOPMENTAL BIOLOGY%REACTOME DATABASE ID RELEASE 66%10144967 Developmental Biology GPCR DOWNSTREAM SIGNALLING%REACTOME DATABASE ID RELEASE 66%10144869 GPCR downstream signalling PHOSPHATE BOND HYDROLYSIS BY NTPDASE PROTEINS%REACTOME DATABASE ID RELEASE 66%10146210 Phosphate bond hydrolysis by NTPDase proteins ANTAGONISM OF ACTIVIN BY FOLLISTATIN%REACTOME%R-RNO-2473224.1 Antagonism of Activin by Follistatin PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR%REACTOME%R-RNO-392851.1 Prostacyclin signalling through prostacyclin receptor CHOLINE CATABOLISM%REACTOME%R-RNO-6798163.1 Choline catabolism MULTIFUNCTIONAL ANION EXCHANGERS%REACTOME DATABASE ID RELEASE 66%10145626 Multifunctional anion exchangers TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 66%10144823 tRNA Aminoacylation OLFACTORY SIGNALING PATHWAY%REACTOME%R-RNO-381753.1 Olfactory Signaling Pathway VLDLR INTERNALISATION AND DEGRADATION%REACTOME%R-RNO-8866427.1 VLDLR internalisation and degradation BETA OXIDATION OF HEXANOYL-COA TO BUTANOYL-COA%REACTOME%R-RNO-77350.1 Beta oxidation of hexanoyl-CoA to butanoyl-CoA FANCONI ANEMIA PATHWAY%REACTOME%R-RNO-6783310.1 Fanconi Anemia Pathway REGULATION OF TP53 ACTIVITY THROUGH ASSOCIATION WITH CO-FACTORS%REACTOME%R-RNO-6804759.1 Regulation of TP53 Activity through Association with Co-factors CLEC7A (DECTIN-1) INDUCES NFAT ACTIVATION%REACTOME%R-RNO-5607763.1 CLEC7A (Dectin-1) induces NFAT activation GP1B-IX-V ACTIVATION SIGNALLING%REACTOME DATABASE ID RELEASE 66%10145640 GP1b-IX-V activation signalling CATION-COUPLED CHLORIDE COTRANSPORTERS%REACTOME DATABASE ID RELEASE 66%10145620 Cation-coupled Chloride cotransporters FGFRL1 MODULATION OF FGFR1 SIGNALING%REACTOME%R-RNO-5658623.1 FGFRL1 modulation of FGFR1 signaling APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS%REACTOME%R-RNO-111465.1 Apoptotic cleavage of cellular proteins MICRORNA (MIRNA) BIOGENESIS%REACTOME%R-RNO-203927.1 MicroRNA (miRNA) biogenesis STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES%REACTOME%R-RNO-1834941.1 STING mediated induction of host immune responses MEIOTIC RECOMBINATION%REACTOME%R-RNO-912446.1 Meiotic recombination RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF KERATINOCYTES%REACTOME DATABASE ID RELEASE 66%10146265 RUNX1 regulates transcription of genes involved in differentiation of keratinocytes MITOCHONDRIAL PROTEIN IMPORT%REACTOME DATABASE ID RELEASE 66%10146287 Mitochondrial protein import ENZYMATIC DEGRADATION OF DOPAMINE BY MONOAMINE OXIDASE%REACTOME DATABASE ID RELEASE 66%10145518 Enzymatic degradation of Dopamine by monoamine oxidase G ALPHA (Z) SIGNALLING EVENTS%REACTOME%R-RNO-418597.1 G alpha (z) signalling events SURFACTANT METABOLISM%REACTOME DATABASE ID RELEASE 66%10145605 Surfactant metabolism AUTODEGRADATION OF CDH1 BY CDH1:APC C%REACTOME DATABASE ID RELEASE 66%10145213 Autodegradation of Cdh1 by Cdh1:APC C GLYCOPROTEIN HORMONES%REACTOME DATABASE ID RELEASE 66%10145514 Glycoprotein hormones RRNA PROCESSING IN THE NUCLEUS AND CYTOSOL%REACTOME DATABASE ID RELEASE 66%10146162 rRNA processing in the nucleus and cytosol INITIATION OF NUCLEAR ENVELOPE REFORMATION%REACTOME DATABASE ID RELEASE 66%10145989 Initiation of Nuclear Envelope Reformation METABOLISM OF STEROIDS%REACTOME DATABASE ID RELEASE 66%10145088 Metabolism of steroids REGULATION OF GENE EXPRESSION IN BETA CELLS%REACTOME%R-RNO-210745.1 Regulation of gene expression in beta cells ACTIVATION OF BH3-ONLY PROTEINS%REACTOME DATABASE ID RELEASE 66%10145046 Activation of BH3-only proteins EXPRESSION AND PROCESSING OF NEUROTROPHINS%REACTOME%R-RNO-9036866.1 Expression and Processing of Neurotrophins G2 PHASE%REACTOME DATABASE ID RELEASE 66%10145274 G2 Phase CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION%REACTOME%R-RNO-109688.1 Cleavage of Growing Transcript in the Termination Region CA2+ PATHWAY%REACTOME DATABASE ID RELEASE 66%10145578 Ca2+ pathway VITAMIN E%REACTOME DATABASE ID RELEASE 66%10146249 Vitamin E INTRACELLULAR SIGNALING BY SECOND MESSENGERS%REACTOME DATABASE ID RELEASE 66%10144994 Intracellular signaling by second messengers RECEPTOR MEDIATED MITOPHAGY%REACTOME DATABASE ID RELEASE 66%10146273 Receptor Mediated Mitophagy SOS-MEDIATED SIGNALLING%REACTOME%R-RNO-112412.1 SOS-mediated signalling TCF DEPENDENT SIGNALING IN RESPONSE TO WNT%REACTOME%R-RNO-201681.1 TCF dependent signaling in response to WNT OTHER INTERLEUKIN SIGNALING%REACTOME%R-RNO-449836.1 Other interleukin signaling INTRA-GOLGI TRAFFIC%REACTOME DATABASE ID RELEASE 66%10146194 Intra-Golgi traffic GRB2 EVENTS IN ERBB2 SIGNALING%REACTOME DATABASE ID RELEASE 66%10145849 GRB2 events in ERBB2 signaling DAP12 INTERACTIONS%REACTOME%R-RNO-2172127.1 DAP12 interactions ORGANIC ANION TRANSPORT%REACTOME%R-RNO-561048.1 Organic anion transport TRYPTOPHAN CATABOLISM%REACTOME%R-RNO-71240.1 Tryptophan catabolism SYNTHESIS OF LIPOXINS (LX)%REACTOME DATABASE ID RELEASE 66%10145463 Synthesis of Lipoxins (LX) AXONAL GROWTH STIMULATION%REACTOME%R-RNO-209563.1 Axonal growth stimulation SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL%REACTOME%R-RNO-1855183.1 Synthesis of IP2, IP, and Ins in the cytosol RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 66%10144903 RNA Polymerase II Transcription Initiation And Promoter Clearance SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21%REACTOME DATABASE ID RELEASE 66%10145271 SCF(Skp2)-mediated degradation of p27 p21 GLYOXYLATE METABOLISM AND GLYCINE DEGRADATION%REACTOME%R-RNO-389661.1 Glyoxylate metabolism and glycine degradation ERYTHROPOIETIN ACTIVATES RAS%REACTOME DATABASE ID RELEASE 66%10146321 Erythropoietin activates RAS MITOCHONDRIAL UNCOUPLING PROTEINS%REACTOME DATABASE ID RELEASE 66%10145136 Mitochondrial Uncoupling Proteins INTERACTION BETWEEN L1 AND ANKYRINS%REACTOME DATABASE ID RELEASE 66%10145576 Interaction between L1 and Ankyrins REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX%REACTOME%R-RNO-204174.1 Regulation of pyruvate dehydrogenase (PDH) complex ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S%REACTOME%R-RNO-72662.1 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S SYNTHESIS OF DOLICHYL-PHOSPHATE%REACTOME DATABASE ID RELEASE 66%10145306 Synthesis of Dolichyl-phosphate KETONE BODY CATABOLISM%REACTOME%R-RNO-77108.1 Ketone body catabolism REDUCTION OF CYTOSOLIC CA++ LEVELS%REACTOME%R-RNO-418359.1 Reduction of cytosolic Ca++ levels TCR SIGNALING%REACTOME DATABASE ID RELEASE 66%10145376 TCR signaling SUMOYLATION%REACTOME%R-RNO-2990846.1 SUMOylation CALMODULIN INDUCED EVENTS%REACTOME DATABASE ID RELEASE 66%10144991 Calmodulin induced events ACTIVATION OF PKB%REACTOME DATABASE ID RELEASE 66%10144955 Activation of PKB MET ACTIVATES PTK2 SIGNALING%REACTOME DATABASE ID RELEASE 66%10146246 MET activates PTK2 signaling OPIOID SIGNALLING%REACTOME%R-RNO-111885.1 Opioid Signalling SIGNALING BY ERBB2%REACTOME%R-RNO-1227986.1 Signaling by ERBB2 PHASE 0 - RAPID DEPOLARISATION%REACTOME DATABASE ID RELEASE 66%10146067 Phase 0 - rapid depolarisation MISCELLANEOUS SUBSTRATES%REACTOME DATABASE ID RELEASE 66%10145442 Miscellaneous substrates HATS ACETYLATE HISTONES%REACTOME%R-RNO-3214847.1 HATs acetylate histones REGULATION OF IFNA SIGNALING%REACTOME%R-RNO-912694.1 Regulation of IFNA signaling ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES%REACTOME%R-RNO-1169410.1 Antiviral mechanism by IFN-stimulated genes SIGNALING BY NOTCH4%REACTOME DATABASE ID RELEASE 66%10146330 Signaling by NOTCH4 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM%REACTOME DATABASE ID RELEASE 66%10144804 Cobalamin (Cbl, vitamin B12) transport and metabolism ASSEMBLY OF ACTIVE LPL AND LIPC LIPASE COMPLEXES%REACTOME DATABASE ID RELEASE 66%10146149 Assembly of active LPL and LIPC lipase complexes SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX)%REACTOME%R-RNO-2162123.1 Synthesis of Prostaglandins (PG) and Thromboxanes (TX) INTERLEUKIN-38 SIGNALING%REACTOME DATABASE ID RELEASE 66%10146291 Interleukin-38 signaling AUF1 (HNRNP D0) BINDS AND DESTABILIZES MRNA%REACTOME DATABASE ID RELEASE 66%10145697 AUF1 (hnRNP D0) binds and destabilizes mRNA CYTOKINE SIGNALING IN IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 66%10145164 Cytokine Signaling in Immune system FORMATION OF A POOL OF FREE 40S SUBUNITS%REACTOME%R-RNO-72689.1 Formation of a pool of free 40S subunits LRR FLII-INTERACTING PROTEIN 1 (LRRFIP1) ACTIVATES TYPE I IFN PRODUCTION%REACTOME%R-RNO-3134973.1 LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production DISSOLUTION OF FIBRIN CLOT%REACTOME DATABASE ID RELEASE 66%10145082 Dissolution of Fibrin Clot RESOLUTION OF D-LOOP STRUCTURES THROUGH HOLLIDAY JUNCTION INTERMEDIATES%REACTOME%R-RNO-5693568.1 Resolution of D-loop Structures through Holliday Junction Intermediates RETINOID METABOLISM AND TRANSPORT%REACTOME DATABASE ID RELEASE 66%10145777 Retinoid metabolism and transport METABOLISM OF VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 66%10144806 Metabolism of vitamins and cofactors FIBRONECTIN MATRIX FORMATION%REACTOME%R-RNO-1566977.1 Fibronectin matrix formation RMTS METHYLATE HISTONE ARGININES%REACTOME%R-RNO-3214858.1 RMTs methylate histone arginines AMPK INHIBITS CHREBP TRANSCRIPTIONAL ACTIVATION ACTIVITY%REACTOME DATABASE ID RELEASE 66%10145123 AMPK inhibits chREBP transcriptional activation activity MAPK FAMILY SIGNALING CASCADES%REACTOME%R-RNO-5683057.1 MAPK family signaling cascades ACTIVATION OF NIMA KINASES NEK9, NEK6, NEK7%REACTOME%R-RNO-2980767.1 Activation of NIMA Kinases NEK9, NEK6, NEK7 CYSTEINE FORMATION FROM HOMOCYSTEINE%REACTOME%R-RNO-1614603.1 Cysteine formation from homocysteine NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION)%REACTOME%R-RNO-198725.1 Nuclear Events (kinase and transcription factor activation) PYRIMIDINE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 66%10144841 Pyrimidine biosynthesis ADAPTIVE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 66%10145356 Adaptive Immune System RAF-INDEPENDENT MAPK1 3 ACTIVATION%REACTOME DATABASE ID RELEASE 66%10144960 RAF-independent MAPK1 3 activation RNA POLYMERASE II TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 66%10144832 RNA Polymerase II Transcription Termination SYNTHESIS OF KETONE BODIES%REACTOME%R-RNO-77111.1 Synthesis of Ketone Bodies LACTOSE SYNTHESIS%REACTOME DATABASE ID RELEASE 66%10146097 Lactose synthesis DOWNSTREAM SIGNALING OF ACTIVATED FGFR4%REACTOME DATABASE ID RELEASE 66%10145261 Downstream signaling of activated FGFR4 VXPX CARGO-TARGETING TO CILIUM%REACTOME DATABASE ID RELEASE 66%10146083 VxPx cargo-targeting to cilium THE ROLE OF GTSE1 IN G2 M PROGRESSION AFTER G2 CHECKPOINT%REACTOME%R-RNO-8852276.1 The role of GTSE1 in G2 M progression after G2 checkpoint TWIK-RELATED SPINAL CORD K+ CHANNEL (TRESK)%REACTOME DATABASE ID RELEASE 66%10145846 TWIK-related spinal cord K+ channel (TRESK) NEUROTRANSMITTER RELEASE CYCLE%REACTOME%R-RNO-112310.1 Neurotransmitter release cycle FREE FATTY ACID RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145661 Free fatty acid receptors MAPK1 (ERK2) ACTIVATION%REACTOME DATABASE ID RELEASE 66%10144963 MAPK1 (ERK2) activation PROCESSING AND ACTIVATION OF SUMO%REACTOME%R-RNO-3215018.1 Processing and activation of SUMO RNA POLYMERASE II TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 66%10144905 RNA Polymerase II Transcription Initiation RUNX3 REGULATES WNT SIGNALING%REACTOME DATABASE ID RELEASE 66%10146277 RUNX3 regulates WNT signaling FORMATION OF EDITOSOMES BY ADAR PROTEINS%REACTOME%R-RNO-77042.1 Formation of editosomes by ADAR proteins ARACHIDONIC ACID METABOLISM%REACTOME%R-RNO-2142753.1 Arachidonic acid metabolism ION TRANSPORT BY P-TYPE ATPASES%REACTOME%R-RNO-936837.1 Ion transport by P-type ATPases PI-3K CASCADE:FGFR4%REACTOME%R-RNO-5654720.1 PI-3K cascade:FGFR4 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS%REACTOME DATABASE ID RELEASE 66%10144984 SLBP independent Processing of Histone Pre-mRNAs G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA%REACTOME%R-RNO-392451.1 G beta:gamma signalling through PI3Kgamma CLEC7A (DECTIN-1) SIGNALING%REACTOME%R-RNO-5607764.1 CLEC7A (Dectin-1) signaling CELL-EXTRACELLULAR MATRIX INTERACTIONS%REACTOME DATABASE ID RELEASE 66%10145642 Cell-extracellular matrix interactions SODIUM PROTON EXCHANGERS%REACTOME%R-RNO-425986.1 Sodium Proton exchangers INTERLEUKIN-7 SIGNALING%REACTOME%R-RNO-1266695.1 Interleukin-7 signaling ATTACHMENT OF GPI ANCHOR TO UPAR%REACTOME DATABASE ID RELEASE 66%10145107 Attachment of GPI anchor to uPAR ANTIGEN PROCESSING-CROSS PRESENTATION%REACTOME DATABASE ID RELEASE 66%10145813 Antigen processing-Cross presentation CALCITONIN-LIKE LIGAND RECEPTORS%REACTOME%R-RNO-419812.1 Calcitonin-like ligand receptors TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER%REACTOME%R-RNO-2173793.1 Transcriptional activity of SMAD2 SMAD3:SMAD4 heterotrimer P75NTR REGULATES AXONOGENESIS%REACTOME%R-RNO-193697.1 p75NTR regulates axonogenesis MET ACTIVATES PTPN11%REACTOME%R-RNO-8865999.1 MET activates PTPN11 RUNX1 AND FOXP3 CONTROL THE DEVELOPMENT OF REGULATORY T LYMPHOCYTES (TREGS)%REACTOME%R-RNO-8877330.1 RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) BILE ACID AND BILE SALT METABOLISM%REACTOME%R-RNO-194068.1 Bile acid and bile salt metabolism PREGNENOLONE BIOSYNTHESIS%REACTOME%R-RNO-196108.1 Pregnenolone biosynthesis CS DS DEGRADATION%REACTOME DATABASE ID RELEASE 66%10145885 CS DS degradation PI AND PC TRANSPORT BETWEEN ER AND GOLGI MEMBRANES%REACTOME%R-RNO-1483196.1 PI and PC transport between ER and Golgi membranes REELIN SIGNALLING PATHWAY%REACTOME DATABASE ID RELEASE 66%10146225 Reelin signalling pathway MRNA EDITING: A TO I CONVERSION%REACTOME%R-RNO-75064.1 mRNA Editing: A to I Conversion PHOSPHOLIPASE C-MEDIATED CASCADE; FGFR2%REACTOME DATABASE ID RELEASE 66%10146098 Phospholipase C-mediated cascade; FGFR2 MITOCHONDRIAL CALCIUM ION TRANSPORT%REACTOME%R-RNO-8949215.1 Mitochondrial calcium ion transport MITOCHONDRIAL ABC TRANSPORTERS%REACTOME%R-RNO-1369007.1 Mitochondrial ABC transporters TERMINATION OF TRANSLESION DNA SYNTHESIS%REACTOME DATABASE ID RELEASE 66%10146096 Termination of translesion DNA synthesis PEPTIDE HORMONE BIOSYNTHESIS%REACTOME%R-RNO-209952.1 Peptide hormone biosynthesis MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS%REACTOME%R-RNO-1362409.1 Mitochondrial iron-sulfur cluster biogenesis SEROTONIN NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 66%10145528 Serotonin Neurotransmitter Release Cycle LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATION FROM THE CENTROSOME%REACTOME%R-RNO-380284.1 Loss of proteins required for interphase microtubule organization from the centrosome LECTIN PATHWAY OF COMPLEMENT ACTIVATION%REACTOME%R-RNO-166662.1 Lectin pathway of complement activation FORMATION OF THE EARLY ELONGATION COMPLEX%REACTOME DATABASE ID RELEASE 66%10145012 Formation of the Early Elongation Complex PTK6 PROMOTES HIF1A STABILIZATION%REACTOME%R-RNO-8857538.1 PTK6 promotes HIF1A stabilization METABOLISM OF STEROID HORMONES%REACTOME DATABASE ID RELEASE 66%10145319 Metabolism of steroid hormones CHREBP ACTIVATES METABOLIC GENE EXPRESSION%REACTOME DATABASE ID RELEASE 66%10145124 ChREBP activates metabolic gene expression UREA CYCLE%REACTOME DATABASE ID RELEASE 66%10144786 Urea cycle MRNA EDITING%REACTOME%R-RNO-75072.1 mRNA Editing BETA OXIDATION OF LAUROYL-COA TO DECANOYL-COA-COA%REACTOME DATABASE ID RELEASE 66%10144931 Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA CASP8 ACTIVITY IS INHIBITED%REACTOME%R-RNO-5218900.1 CASP8 activity is inhibited PTK6 REGULATES CELL CYCLE%REACTOME DATABASE ID RELEASE 66%10146203 PTK6 Regulates Cell Cycle HYDROXYCARBOXYLIC ACID-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145664 Hydroxycarboxylic acid-binding receptors EFFECTS OF PIP2 HYDROLYSIS%REACTOME%R-RNO-114508.1 Effects of PIP2 hydrolysis UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A%REACTOME DATABASE ID RELEASE 66%10144752 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A SYNTHESIS OF PS%REACTOME%R-RNO-1483101.1 Synthesis of PS PHASE 4 - RESTING MEMBRANE POTENTIAL%REACTOME%R-RNO-5576886.1 Phase 4 - resting membrane potential NOTCH3 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME DATABASE ID RELEASE 66%10145951 NOTCH3 Activation and Transmission of Signal to the Nucleus BETA OXIDATION OF BUTANOYL-COA TO ACETYL-COA%REACTOME DATABASE ID RELEASE 66%10144935 Beta oxidation of butanoyl-CoA to acetyl-CoA UNWINDING OF DNA%REACTOME%R-RNO-176974.1 Unwinding of DNA PKB-MEDIATED EVENTS%REACTOME%R-RNO-109703.1 PKB-mediated events JOSEPHIN DOMAIN DUBS%REACTOME DATABASE ID RELEASE 66%10146138 Josephin domain DUBs HSP90 CHAPERONE CYCLE FOR SHRS%REACTOME DATABASE ID RELEASE 66%10146010 HSP90 chaperone cycle for SHRs NEUROFASCIN INTERACTIONS%REACTOME%R-RNO-447043.1 Neurofascin interactions COMPLEX I BIOGENESIS%REACTOME%R-RNO-6799198.1 Complex I biogenesis RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+%REACTOME%R-RNO-76005.1 Response to elevated platelet cytosolic Ca2+ GLUCONEOGENESIS%REACTOME%R-RNO-70263.1 Gluconeogenesis MAPK6 MAPK4 SIGNALING%REACTOME%R-RNO-5687128.1 MAPK6 MAPK4 signaling SIGNALING BY NUCLEAR RECEPTORS%REACTOME%R-RNO-9006931.1 Signaling by Nuclear Receptors ENOS ACTIVATION%REACTOME DATABASE ID RELEASE 66%10145394 eNOS activation GABA RECEPTOR ACTIVATION%REACTOME%R-RNO-977443.1 GABA receptor activation REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR%REACTOME DATABASE ID RELEASE 66%10145809 Regulation of gene expression by Hypoxia-inducible Factor STEROLS ARE 12-HYDROXYLATED BY CYP8B1%REACTOME%R-RNO-211994.1 Sterols are 12-hydroxylated by CYP8B1 WNT LIGAND BIOGENESIS AND TRAFFICKING%REACTOME%R-RNO-3238698.1 WNT ligand biogenesis and trafficking MET RECEPTOR ACTIVATION%REACTOME DATABASE ID RELEASE 66%10146172 MET Receptor Activation GPCR LIGAND BINDING%REACTOME DATABASE ID RELEASE 66%10145122 GPCR ligand binding TRIGLYCERIDE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 66%10144910 Triglyceride biosynthesis BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME%R-RNO-70895.1 Branched-chain amino acid catabolism NTRK2 ACTIVATES RAC1%REACTOME DATABASE ID RELEASE 66%10146322 NTRK2 activates RAC1 SIGNALING BY ERBB4%REACTOME%R-RNO-1236394.1 Signaling by ERBB4 DNA DAMAGE REVERSAL%REACTOME DATABASE ID RELEASE 66%10146231 DNA Damage Reversal DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX%REACTOME%R-RNO-3769402.1 Deactivation of the beta-catenin transactivating complex RECRUITMENT AND ATM-MEDIATED PHOSPHORYLATION OF REPAIR AND SIGNALING PROTEINS AT DNA DOUBLE STRAND BREAKS%REACTOME DATABASE ID RELEASE 66%10144760 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE%REACTOME%R-RNO-168179.1 Toll Like Receptor TLR1:TLR2 Cascade HEDGEHOG 'OFF' STATE%REACTOME%R-RNO-5610787.1 Hedgehog 'off' state APC-CDC20 MEDIATED DEGRADATION OF NEK2A%REACTOME DATABASE ID RELEASE 66%10145263 APC-Cdc20 mediated degradation of Nek2A NFG AND PRONGF BINDS TO P75NTR%REACTOME%R-RNO-205017.1 NFG and proNGF binds to p75NTR TRANSCRIPTIONAL ACTIVATION OF CELL CYCLE INHIBITOR P21%REACTOME DATABASE ID RELEASE 66%10146177 Transcriptional activation of cell cycle inhibitor p21 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS%REACTOME%R-RNO-416993.1 Trafficking of GluR2-containing AMPA receptors PROLINE CATABOLISM%REACTOME DATABASE ID RELEASE 66%10144794 Proline catabolism DEGRADATION OF GLI1 BY THE PROTEASOME%REACTOME DATABASE ID RELEASE 66%10146077 Degradation of GLI1 by the proteasome BETA OXIDATION OF DECANOYL-COA TO OCTANOYL-COA-COA%REACTOME%R-RNO-77346.1 Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA MMR%REACTOME%R-RNO-5358508.1 MMR POST-TRANSCRIPTIONAL SILENCING BY SMALL RNAS%REACTOME DATABASE ID RELEASE 66%10145622 Post-transcriptional silencing by small RNAs PI METABOLISM%REACTOME DATABASE ID RELEASE 66%10145378 PI Metabolism NEGATIVE REGULATION OF FGFR4 SIGNALING%REACTOME%R-RNO-5654733.1 Negative regulation of FGFR4 signaling NUCLEOBASE CATABOLISM%REACTOME%R-RNO-8956319.1 Nucleobase catabolism CROSS-PRESENTATION OF PARTICULATE EXOGENOUS ANTIGENS (PHAGOSOMES)%REACTOME%R-RNO-1236973.1 Cross-presentation of particulate exogenous antigens (phagosomes) MEIOSIS%REACTOME%R-RNO-1500620.1 Meiosis AKT-MEDIATED INACTIVATION OF FOXO1A%REACTOME DATABASE ID RELEASE 66%10145436 AKT-mediated inactivation of FOXO1A CREB PHOSPHORYLATION%REACTOME%R-RNO-199920.1 CREB phosphorylation RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN INTERLEUKIN SIGNALING%REACTOME DATABASE ID RELEASE 66%10146268 RUNX1 regulates transcription of genes involved in interleukin signaling SDK INTERACTIONS%REACTOME%R-RNO-373756.1 SDK interactions XENOBIOTICS%REACTOME DATABASE ID RELEASE 66%10144919 Xenobiotics SIGNALING PATHWAYS%REACTOME%R-RNO-162582.1 Signaling Pathways TRAF6 MEDIATED IRF7 ACTIVATION%REACTOME DATABASE ID RELEASE 66%10145758 TRAF6 mediated IRF7 activation NEUROTRANSMITTER RECEPTORS AND POSTSYNAPTIC SIGNAL TRANSMISSION%REACTOME%R-RNO-112314.1 Neurotransmitter receptors and postsynaptic signal transmission PLASMALOGEN BIOSYNTHESIS%REACTOME%R-RNO-75896.1 Plasmalogen biosynthesis TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING%REACTOME%R-RNO-975110.1 TRAF6 mediated IRF7 activation in TLR7 8 or 9 signaling ABACAVIR TRANSMEMBRANE TRANSPORT%REACTOME%R-RNO-2161517.1 Abacavir transmembrane transport RNA POLYMERASE I PROMOTER CLEARANCE%REACTOME%R-RNO-73854.1 RNA Polymerase I Promoter Clearance FCERI MEDIATED NF-KB ACTIVATION%REACTOME%R-RNO-2871837.1 FCERI mediated NF-kB activation THE AIM2 INFLAMMASOME%REACTOME%R-RNO-844615.1 The AIM2 inflammasome FORMATION OF RNA POL II ELONGATION COMPLEX%REACTOME%R-RNO-112382.1 Formation of RNA Pol II elongation complex NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%R-RNO-427413.1 NoRC negatively regulates rRNA expression FGFR3C LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 66%10145291 FGFR3c ligand binding and activation FATTY ACID METABOLISM%REACTOME%R-RNO-8978868.1 Fatty acid metabolism TNF RECEPTOR SUPERFAMILY (TNFSF) MEMBERS MEDIATING NON-CANONICAL NF-KB PATHWAY%REACTOME DATABASE ID RELEASE 66%10145372 TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway VEGFR2 MEDIATED VASCULAR PERMEABILITY%REACTOME%R-RNO-5218920.1 VEGFR2 mediated vascular permeability PI5P, PP2A AND IER3 REGULATE PI3K AKT SIGNALING%REACTOME%R-RNO-6811558.1 PI5P, PP2A and IER3 Regulate PI3K AKT Signaling FGFR1 LIGAND BINDING AND ACTIVATION%REACTOME%R-RNO-190242.1 FGFR1 ligand binding and activation SYNTHESIS OF PIPS AT THE ER MEMBRANE%REACTOME DATABASE ID RELEASE 66%10145900 Synthesis of PIPs at the ER membrane RHO GTPASES ACTIVATE IQGAPS%REACTOME DATABASE ID RELEASE 66%10146088 RHO GTPases activate IQGAPs RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 66%10145527 Recruitment of NuMA to mitotic centrosomes GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION%REACTOME%R-RNO-163841.1 Gamma carboxylation, hypusine formation and arylsulfatase activation GLYCINE DEGRADATION%REACTOME DATABASE ID RELEASE 66%10146148 Glycine degradation TANDEM PORE DOMAIN POTASSIUM CHANNELS%REACTOME DATABASE ID RELEASE 66%10145839 Tandem pore domain potassium channels DEGRADATION OF THE EXTRACELLULAR MATRIX%REACTOME%R-RNO-1474228.1 Degradation of the extracellular matrix ACYL CHAIN REMODELLING OF PG%REACTOME DATABASE ID RELEASE 66%10145863 Acyl chain remodelling of PG ACYL CHAIN REMODELING OF DAG AND TAG%REACTOME%R-RNO-1482883.1 Acyl chain remodeling of DAG and TAG NUCLEAR ENVELOPE BREAKDOWN%REACTOME DATABASE ID RELEASE 66%10145982 Nuclear Envelope Breakdown APC:CDC20 MEDIATED DEGRADATION OF CELL CYCLE PROTEINS PRIOR TO SATISFATION OF THE CELL CYCLE CHECKPOINT%REACTOME%R-RNO-179419.1 APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC%REACTOME DATABASE ID RELEASE 66%10145414 Antigen Presentation: Folding, assembly and peptide loading of class I MHC BLOCH PATHWAY%REACTOME%R-RNO-6807047.1 Bloch pathway RNA POLYMERASE I PROMOTER ESCAPE%REACTOME%R-RNO-73772.1 RNA Polymerase I Promoter Escape HDR THROUGH MMEJ (ALT-NHEJ)%REACTOME DATABASE ID RELEASE 66%10146137 HDR through MMEJ (alt-NHEJ) ALPHA-DEFENSINS%REACTOME%R-RNO-1462054.1 Alpha-defensins TOLL LIKE RECEPTOR 3 (TLR3) CASCADE%REACTOME DATABASE ID RELEASE 66%10145161 Toll Like Receptor 3 (TLR3) Cascade MET INTERACTS WITH TNS PROTEINS%REACTOME DATABASE ID RELEASE 66%10146251 MET interacts with TNS proteins INTERFERON GAMMA SIGNALING%REACTOME%R-RNO-877300.1 Interferon gamma signaling MAJOR PATHWAY OF RRNA PROCESSING IN THE NUCLEOLUS AND CYTOSOL%REACTOME%R-RNO-6791226.1 Major pathway of rRNA processing in the nucleolus and cytosol MET ACTIVATES STAT3%REACTOME%R-RNO-8875791.1 MET activates STAT3 ERYTHROCYTES TAKE UP CARBON DIOXIDE AND RELEASE OXYGEN%REACTOME DATABASE ID RELEASE 66%10145817 Erythrocytes take up carbon dioxide and release oxygen RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN BCR SIGNALING%REACTOME DATABASE ID RELEASE 66%10146269 RUNX1 regulates transcription of genes involved in BCR signaling G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%R-RNO-1296059.1 G protein gated Potassium channels CLEARANCE OF SERATONIN%REACTOME%R-RNO-380615.1 Clearance of seratonin MITOTIC PROMETAPHASE%REACTOME DATABASE ID RELEASE 66%10145506 Mitotic Prometaphase PLATELET SENSITIZATION BY LDL%REACTOME DATABASE ID RELEASE 66%10145634 Platelet sensitization by LDL REGULATION OF RUNX2 EXPRESSION AND ACTIVITY%REACTOME%R-RNO-8939902.1 Regulation of RUNX2 expression and activity RAB GERANYLGERANYLATION%REACTOME%R-RNO-8873719.1 RAB geranylgeranylation NEUROTRANSMITTER UPTAKE AND METABOLISM IN GLIAL CELLS%REACTOME%R-RNO-112313.1 Neurotransmitter uptake and metabolism In glial cells RAB GEFS EXCHANGE GTP FOR GDP ON RABS%REACTOME%R-RNO-8876198.1 RAB GEFs exchange GTP for GDP on RABs PRESYNAPTIC DEPOLARIZATION AND CALCIUM CHANNEL OPENING%REACTOME%R-RNO-112308.1 Presynaptic depolarization and calcium channel opening RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING%REACTOME DATABASE ID RELEASE 66%10144894 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening HISTIDINE CATABOLISM%REACTOME%R-RNO-70921.1 Histidine catabolism SIGNALING BY HIPPO%REACTOME DATABASE ID RELEASE 66%10145927 Signaling by Hippo RIBOSOMAL SCANNING AND START CODON RECOGNITION%REACTOME DATABASE ID RELEASE 66%10144836 Ribosomal scanning and start codon recognition PLATELET AGGREGATION (PLUG FORMATION)%REACTOME DATABASE ID RELEASE 66%10145477 Platelet Aggregation (Plug Formation) HEME BIOSYNTHESIS%REACTOME%R-RNO-189451.1 Heme biosynthesis NOD1 2 SIGNALING PATHWAY%REACTOME%R-RNO-168638.1 NOD1 2 Signaling Pathway INTERLEUKIN-4 AND INTERLEUKIN-13 SIGNALING%REACTOME%R-RNO-6785807.1 Interleukin-4 and Interleukin-13 signaling RELAXIN RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145665 Relaxin receptors ORGANIC CATION ANION ZWITTERION TRANSPORT%REACTOME%R-RNO-549132.1 Organic cation anion zwitterion transport CARNITINE SYNTHESIS%REACTOME DATABASE ID RELEASE 66%10144812 Carnitine synthesis CAM-PDE 1 ACTIVATION%REACTOME DATABASE ID RELEASE 66%10145008 Cam-PDE 1 activation HDR THROUGH SINGLE STRAND ANNEALING (SSA)%REACTOME DATABASE ID RELEASE 66%10144912 HDR through Single Strand Annealing (SSA) FASL CD95L SIGNALING%REACTOME%R-RNO-75157.1 FasL CD95L signaling SUMO IS PROTEOLYTICALLY PROCESSED%REACTOME%R-RNO-3065679.1 SUMO is proteolytically processed MAP2K AND MAPK ACTIVATION%REACTOME%R-RNO-5674135.1 MAP2K and MAPK activation ACTIVATION OF RAS IN B CELLS%REACTOME%R-RNO-1169092.1 Activation of RAS in B cells SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1%REACTOME DATABASE ID RELEASE 66%10145226 SCF-beta-TrCP mediated degradation of Emi1 ETHANOL OXIDATION%REACTOME DATABASE ID RELEASE 66%10144819 Ethanol oxidation RHO GTPASES REGULATE CFTR TRAFFICKING%REACTOME DATABASE ID RELEASE 66%10146090 RHO GTPases regulate CFTR trafficking FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF)%REACTOME DATABASE ID RELEASE 66%10146023 Formation of Senescence-Associated Heterochromatin Foci (SAHF) GOLGI-TO-ER RETROGRADE TRANSPORT%REACTOME%R-RNO-8856688.1 Golgi-to-ER retrograde transport REGULATION OF TP53 ACTIVITY THROUGH METHYLATION%REACTOME DATABASE ID RELEASE 66%10146002 Regulation of TP53 Activity through Methylation RESPIRATORY ELECTRON TRANSPORT%REACTOME%R-RNO-611105.1 Respiratory electron transport REVERSIBLE HYDRATION OF CARBON DIOXIDE%REACTOME%R-RNO-1475029.1 Reversible hydration of carbon dioxide SENSING OF DNA DOUBLE STRAND BREAKS%REACTOME%R-RNO-5693548.1 Sensing of DNA Double Strand Breaks NOSIP MEDIATED ENOS TRAFFICKING%REACTOME DATABASE ID RELEASE 66%10145408 NOSIP mediated eNOS trafficking BIOSYNTHESIS OF PROTECTIN AND RESOLVIN CONJUGATES IN TISSUE REGENERATION (PCTR AND RCTR)%REACTOME%R-RNO-9026766.1 Biosynthesis of protectin and resolvin conjugates in tissue regeneration (PCTR and RCTR) COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES%REACTOME%R-RNO-1650814.1 Collagen biosynthesis and modifying enzymes CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6%REACTOME%R-RNO-69017.1 CDK-mediated phosphorylation and removal of Cdc6 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24-HYDROXYCHOLESTEROL%REACTOME%R-RNO-193775.1 Synthesis of bile acids and bile salts via 24-hydroxycholesterol RUNX3 REGULATES CDKN1A TRANSCRIPTION%REACTOME%R-RNO-8941855.1 RUNX3 regulates CDKN1A transcription INTERLEUKIN-6 FAMILY SIGNALING%REACTOME%R-RNO-6783589.1 Interleukin-6 family signaling NA+ CL- DEPENDENT NEUROTRANSMITTER TRANSPORTERS%REACTOME%R-RNO-442660.1 Na+ Cl- dependent neurotransmitter transporters REGULATION OF MITOTIC CELL CYCLE%REACTOME%R-RNO-453276.1 Regulation of mitotic cell cycle ERKS ARE INACTIVATED%REACTOME DATABASE ID RELEASE 66%10145380 ERKs are inactivated PRE-NOTCH TRANSCRIPTION AND TRANSLATION%REACTOME DATABASE ID RELEASE 66%10146305 Pre-NOTCH Transcription and Translation VITAMIN B2 (RIBOFLAVIN) METABOLISM%REACTOME DATABASE ID RELEASE 66%10145350 Vitamin B2 (riboflavin) metabolism STABILIZATION OF P53%REACTOME%R-RNO-69541.1 Stabilization of p53 RESPONSE TO METAL IONS%REACTOME DATABASE ID RELEASE 66%10146118 Response to metal ions HYALURONAN METABOLISM%REACTOME%R-RNO-2142845.1 Hyaluronan metabolism ACTIVATION OF NA-PERMEABLE KAINATE RECEPTORS%REACTOME%R-RNO-451307.1 Activation of Na-permeable kainate receptors ELEVATION OF CYTOSOLIC CA2+ LEVELS%REACTOME%R-RNO-139853.1 Elevation of cytosolic Ca2+ levels TRANSLESION SYNTHESIS BY POLI%REACTOME DATABASE ID RELEASE 66%10146112 Translesion synthesis by POLI CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES)%REACTOME DATABASE ID RELEASE 66%10145812 Cross-presentation of soluble exogenous antigens (endosomes) GALACTOSE CATABOLISM%REACTOME DATABASE ID RELEASE 66%10144777 Galactose catabolism ERK MAPK TARGETS%REACTOME DATABASE ID RELEASE 66%10145363 ERK MAPK targets TRANSPORT OF GAMMA-CARBOXYLATED PROTEIN PRECURSORS FROM THE ENDOPLASMIC RETICULUM TO THE GOLGI APPARATUS%REACTOME%R-RNO-159763.1 Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus FORMATION OF TC-NER PRE-INCISION COMPLEX%REACTOME DATABASE ID RELEASE 66%10146151 Formation of TC-NER Pre-Incision Complex EICOSANOIDS%REACTOME%R-RNO-211979.1 Eicosanoids MRNA CAPPING%REACTOME DATABASE ID RELEASE 66%10144929 mRNA Capping MITOTIC SPINDLE CHECKPOINT%REACTOME DATABASE ID RELEASE 66%10145064 Mitotic Spindle Checkpoint SYNTHESIS OF HEPOXILINS (HX) AND TRIOXILINS (TRX)%REACTOME%R-RNO-2142696.1 Synthesis of Hepoxilins (HX) and Trioxilins (TrX) P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME%R-RNO-69613.1 p53-Independent G1 S DNA damage checkpoint SHC1 EVENTS IN ERBB2 SIGNALING%REACTOME DATABASE ID RELEASE 66%10145824 SHC1 events in ERBB2 signaling ACTIVATION OF MATRIX METALLOPROTEINASES%REACTOME%R-RNO-1592389.1 Activation of Matrix Metalloproteinases TANDEM OF PORE DOMAIN IN A WEAK INWARDLY RECTIFYING K+ CHANNELS (TWIK)%REACTOME DATABASE ID RELEASE 66%10145844 Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK) FRUCTOSE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 66%10146095 Fructose biosynthesis TRANSLOCATION OF ZAP-70 TO IMMUNOLOGICAL SYNAPSE%REACTOME DATABASE ID RELEASE 66%10145399 Translocation of ZAP-70 to Immunological synapse BIOSYNTHESIS OF DPAN-3-DERIVED PROTECTINS AND RESOLVINS%REACTOME%R-RNO-9026286.1 Biosynthesis of DPAn-3-derived protectins and resolvins REGULATION OF APOPTOSIS%REACTOME DATABASE ID RELEASE 66%10146243 Regulation of Apoptosis SYNTHESIS OF (16-20)-HYDROXYEICOSATETRAENOIC ACIDS (HETE)%REACTOME%R-RNO-2142816.1 Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) KERATAN SULFATE KERATIN METABOLISM%REACTOME DATABASE ID RELEASE 66%10145729 Keratan sulfate keratin metabolism CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A%REACTOME DATABASE ID RELEASE 66%10145216 Cdc20:Phospho-APC C mediated degradation of Cyclin A LDL CLEARANCE%REACTOME%R-RNO-8964038.1 LDL clearance TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX%REACTOME%R-RNO-445989.1 TAK1 activates NFkB by phosphorylation and activation of IKKs complex CHEMOKINE RECEPTORS BIND CHEMOKINES%REACTOME%R-RNO-380108.1 Chemokine receptors bind chemokines AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL%REACTOME%R-RNO-198323.1 AKT phosphorylates targets in the cytosol PROCESSING OF DNA DOUBLE-STRAND BREAK ENDS%REACTOME DATABASE ID RELEASE 66%10146130 Processing of DNA double-strand break ends CARGO TRAFFICKING TO THE PERICILIARY MEMBRANE%REACTOME DATABASE ID RELEASE 66%10146079 Cargo trafficking to the periciliary membrane GLYCEROPHOSPHOLIPID BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 66%10144908 Glycerophospholipid biosynthesis NEUROPHILIN INTERACTIONS WITH VEGF AND VEGFR%REACTOME%R-RNO-194306.1 Neurophilin interactions with VEGF and VEGFR DNA REPLICATION PRE-INITIATION%REACTOME DATABASE ID RELEASE 66%10144714 DNA Replication Pre-Initiation PRESYNAPTIC FUNCTION OF KAINATE RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145706 Presynaptic function of Kainate receptors NADPH REGENERATION%REACTOME DATABASE ID RELEASE 66%10145547 NADPH regeneration KERATAN SULFATE DEGRADATION%REACTOME%R-RNO-2022857.1 Keratan sulfate degradation BIOSYNTHESIS OF D-SERIES RESOLVINS%REACTOME DATABASE ID RELEASE 66%10146303 Biosynthesis of D-series resolvins AMPLIFICATION OF SIGNAL FROM THE KINETOCHORES%REACTOME%R-RNO-141424.1 Amplification of signal from the kinetochores REGULATION OF INSULIN SECRETION%REACTOME DATABASE ID RELEASE 66%10145114 Regulation of insulin secretion INTERLEUKIN-23 SIGNALING%REACTOME%R-RNO-9020933.1 Interleukin-23 signaling CALCINEURIN ACTIVATES NFAT%REACTOME DATABASE ID RELEASE 66%10145926 Calcineurin activates NFAT RNA POLYMERASE I TRANSCRIPTION%REACTOME%R-RNO-73864.1 RNA Polymerase I Transcription SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS%REACTOME%R-RNO-75876.1 Synthesis of very long-chain fatty acyl-CoAs REGULATION OF COMPLEMENT CASCADE%REACTOME%R-RNO-977606.1 Regulation of Complement cascade MTORC1-MEDIATED SIGNALLING%REACTOME%R-RNO-166208.1 mTORC1-mediated signalling METABOLISM OF POLYAMINES%REACTOME%R-RNO-351202.1 Metabolism of polyamines G2 M CHECKPOINTS%REACTOME DATABASE ID RELEASE 66%10144759 G2 M Checkpoints ORGANIC CATION TRANSPORT%REACTOME%R-RNO-549127.1 Organic cation transport TRANSCRIPTIONAL ACTIVATION OF P53 RESPONSIVE GENES%REACTOME DATABASE ID RELEASE 66%10146178 Transcriptional activation of p53 responsive genes CREATION OF C4 AND C2 ACTIVATORS%REACTOME DATABASE ID RELEASE 66%10145209 Creation of C4 and C2 activators GLUCOSE METABOLISM%REACTOME%R-RNO-70326.1 Glucose metabolism INTERLEUKIN-27 SIGNALING%REACTOME%R-RNO-9020956.1 Interleukin-27 signaling TRANSCRIPTIONAL REGULATION BY THE AP-2 (TFAP2) FAMILY OF TRANSCRIPTION FACTORS%REACTOME%R-RNO-8864260.1 Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION)%REACTOME%R-RNO-2173791.1 TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) NEGATIVE REGULATION OF TCF-DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS%REACTOME DATABASE ID RELEASE 66%10146021 Negative regulation of TCF-dependent signaling by WNT ligand antagonists BETA OXIDATION OF OCTANOYL-COA TO HEXANOYL-COA%REACTOME DATABASE ID RELEASE 66%10144937 Beta oxidation of octanoyl-CoA to hexanoyl-CoA RAB REGULATION OF TRAFFICKING%REACTOME DATABASE ID RELEASE 66%10146223 Rab regulation of trafficking NEUREXINS AND NEUROLIGINS%REACTOME%R-RNO-6794361.1 Neurexins and neuroligins FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS%REACTOME%R-RNO-2029480.1 Fcgamma receptor (FCGR) dependent phagocytosis ENDOGENOUS STEROLS%REACTOME DATABASE ID RELEASE 66%10145314 Endogenous sterols SPRY REGULATION OF FGF SIGNALING%REACTOME DATABASE ID RELEASE 66%10145760 Spry regulation of FGF signaling ER-PHAGOSOME PATHWAY%REACTOME DATABASE ID RELEASE 66%10145816 ER-Phagosome pathway OTHER SEMAPHORIN INTERACTIONS%REACTOME%R-RNO-416700.1 Other semaphorin interactions SIGNALING BY BMP%REACTOME DATABASE ID RELEASE 66%10145385 Signaling by BMP NEGATIVE REGULATION OF FGFR2 SIGNALING%REACTOME DATABASE ID RELEASE 66%10145762 Negative regulation of FGFR2 signaling REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF)%REACTOME DATABASE ID RELEASE 66%10145896 Regulation of cholesterol biosynthesis by SREBP (SREBF) APOPTOSIS%REACTOME DATABASE ID RELEASE 66%10144862 Apoptosis DERMATAN SULFATE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 66%10145924 Dermatan sulfate biosynthesis CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION%REACTOME DATABASE ID RELEASE 66%10144735 Cyclin E associated events during G1 S transition BIOGENIC AMINES ARE OXIDATIVELY DEAMINATED TO ALDEHYDES BY MAOA AND MAOB%REACTOME DATABASE ID RELEASE 66%10145055 Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB TNF SIGNALING%REACTOME%R-RNO-75893.1 TNF signaling DIGESTION OF DIETARY CARBOHYDRATE%REACTOME%R-RNO-189085.1 Digestion of dietary carbohydrate PLATELET DEGRANULATION%REACTOME DATABASE ID RELEASE 66%10145469 Platelet degranulation PROGRAMMED CELL DEATH%REACTOME%R-RNO-5357801.1 Programmed Cell Death SIGNALING BY NOTCH2%REACTOME DATABASE ID RELEASE 66%10145921 Signaling by NOTCH2 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS)%REACTOME DATABASE ID RELEASE 66%10145487 Class A 1 (Rhodopsin-like receptors) TELOMERE C-STRAND SYNTHESIS INITIATION%REACTOME DATABASE ID RELEASE 66%10145233 Telomere C-strand synthesis initiation DCC MEDIATED ATTRACTIVE SIGNALING%REACTOME%R-RNO-418885.1 DCC mediated attractive signaling THE FATTY ACID CYCLING MODEL%REACTOME DATABASE ID RELEASE 66%10145135 The fatty acid cycling model SYNTHESIS OF UDP-N-ACETYL-GLUCOSAMINE%REACTOME%R-RNO-446210.1 Synthesis of UDP-N-acetyl-glucosamine HYALURONAN BIOSYNTHESIS AND EXPORT%REACTOME%R-RNO-2142850.1 Hyaluronan biosynthesis and export SMOOTH MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 66%10145669 Smooth Muscle Contraction DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX%REACTOME%R-RNO-195253.1 Degradation of beta-catenin by the destruction complex POLO-LIKE KINASE MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 66%10145073 Polo-like kinase mediated events SYNTHESIS OF 12-EICOSATETRAENOIC ACID DERIVATIVES%REACTOME DATABASE ID RELEASE 66%10145948 Synthesis of 12-eicosatetraenoic acid derivatives BETAKLOTHO-MEDIATED LIGAND BINDING%REACTOME%R-RNO-1307965.1 betaKlotho-mediated ligand binding CYCLIN D ASSOCIATED EVENTS IN G1%REACTOME DATABASE ID RELEASE 66%10144736 Cyclin D associated events in G1 DNA DOUBLE-STRAND BREAK REPAIR%REACTOME DATABASE ID RELEASE 66%10144762 DNA Double-Strand Break Repair NICOTINATE METABOLISM%REACTOME%R-RNO-196807.1 Nicotinate metabolism ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS%REACTOME DATABASE ID RELEASE 66%10145788 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION)%REACTOME%R-RNO-70614.1 Amino acid synthesis and interconversion (transamination) TRANSPORT OF ORGANIC ANIONS%REACTOME DATABASE ID RELEASE 66%10145337 Transport of organic anions NIK-->NONCANONICAL NF-KB SIGNALING%REACTOME DATABASE ID RELEASE 66%10146074 NIK-->noncanonical NF-kB signaling HISTAMINE RECEPTORS%REACTOME%R-RNO-390650.1 Histamine receptors SHC-MEDIATED CASCADE:FGFR4%REACTOME%R-RNO-5654719.1 SHC-mediated cascade:FGFR4 APEX1-INDEPENDENT RESOLUTION OF AP SITES VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 66%10146092 APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway UNFOLDED PROTEIN RESPONSE (UPR)%REACTOME DATABASE ID RELEASE 66%10145530 Unfolded Protein Response (UPR) STIMULI-SENSING CHANNELS%REACTOME%R-RNO-2672351.1 Stimuli-sensing channels GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS)%REACTOME DATABASE ID RELEASE 66%10144780 Glycogen breakdown (glycogenolysis) B CELL ACTIVATION%REACTOME DATABASE ID RELEASE 66%10145789 B Cell Activation PTK6 REGULATES RHO GTPASES, RAS GTPASE AND MAP KINASES%REACTOME DATABASE ID RELEASE 66%10146205 PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases EPH-EPHRIN SIGNALING%REACTOME DATABASE ID RELEASE 66%10146025 EPH-Ephrin signaling TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN CYTOCHROME C RELEASE%REACTOME%R-RNO-6803204.1 TP53 Regulates Transcription of Genes Involved in Cytochrome C Release POLYMERASE SWITCHING%REACTOME DATABASE ID RELEASE 66%10144729 Polymerase switching PERK REGULATES GENE EXPRESSION%REACTOME DATABASE ID RELEASE 66%10145531 PERK regulates gene expression REGULATION OF RUNX3 EXPRESSION AND ACTIVITY%REACTOME%R-RNO-8941858.1 Regulation of RUNX3 expression and activity LIGAND-RECEPTOR INTERACTIONS%REACTOME DATABASE ID RELEASE 66%10145666 Ligand-receptor interactions PLATELET HOMEOSTASIS%REACTOME DATABASE ID RELEASE 66%10145040 Platelet homeostasis CLASSICAL ANTIBODY-MEDIATED COMPLEMENT ACTIVATION%REACTOME%R-RNO-173623.1 Classical antibody-mediated complement activation ZINC TRANSPORTERS%REACTOME DATABASE ID RELEASE 66%10145654 Zinc transporters TRANSCRIPTIONAL REGULATION BY SMALL RNAS%REACTOME DATABASE ID RELEASE 66%10146071 Transcriptional regulation by small RNAs INTERFERON SIGNALING%REACTOME%R-RNO-913531.1 Interferon Signaling IRS ACTIVATION%REACTOME DATABASE ID RELEASE 66%10144874 IRS activation BUTYROPHILIN (BTN) FAMILY INTERACTIONS%REACTOME%R-RNO-8851680.1 Butyrophilin (BTN) family interactions NUCLEOTIDE SALVAGE%REACTOME%R-RNO-8956321.1 Nucleotide salvage COENZYME A BIOSYNTHESIS%REACTOME%R-RNO-196783.1 Coenzyme A biosynthesis TRANSLESION SYNTHESIS BY POLK%REACTOME DATABASE ID RELEASE 66%10146111 Translesion synthesis by POLK KERATINIZATION%REACTOME%R-RNO-6805567.1 Keratinization MRNA 3'-END PROCESSING%REACTOME DATABASE ID RELEASE 66%10144830 mRNA 3'-end processing MITOCHONDRIAL BIOGENESIS%REACTOME DATABASE ID RELEASE 66%10145879 Mitochondrial biogenesis RIP-MEDIATED NFKB ACTIVATION VIA ZBP1%REACTOME%R-RNO-1810476.1 RIP-mediated NFkB activation via ZBP1 TWIK-RELEATED ACID-SENSITIVE K+ CHANNEL (TASK)%REACTOME DATABASE ID RELEASE 66%10145845 TWIK-releated acid-sensitive K+ channel (TASK) FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX%REACTOME DATABASE ID RELEASE 66%10144838 Formation of the ternary complex, and subsequently, the 43S complex GLYCOGEN SYNTHESIS%REACTOME%R-RNO-3322077.1 Glycogen synthesis IRAK1 RECRUITS IKK COMPLEX%REACTOME DATABASE ID RELEASE 66%10145768 IRAK1 recruits IKK complex G2 M DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 66%10144758 G2 M DNA damage checkpoint SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%R-RNO-427359.1 SIRT1 negatively regulates rRNA expression CONDENSATION OF PROMETAPHASE CHROMOSOMES%REACTOME DATABASE ID RELEASE 66%10145973 Condensation of Prometaphase Chromosomes NEGATIVE REGULATION OF FGFR3 SIGNALING%REACTOME%R-RNO-5654732.1 Negative regulation of FGFR3 signaling NEDDYLATION%REACTOME DATABASE ID RELEASE 66%10146142 Neddylation ORGANELLE BIOGENESIS AND MAINTENANCE%REACTOME DATABASE ID RELEASE 66%10145880 Organelle biogenesis and maintenance P53-INDEPENDENT DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 66%10144753 p53-Independent DNA Damage Response TFAP2 (AP-2) FAMILY REGULATES TRANSCRIPTION OF CELL CYCLE FACTORS%REACTOME%R-RNO-8866911.1 TFAP2 (AP-2) family regulates transcription of cell cycle factors REGULATION OF IFNG SIGNALING%REACTOME DATABASE ID RELEASE 66%10145739 Regulation of IFNG signaling FGFR1C LIGAND BINDING AND ACTIVATION%REACTOME%R-RNO-190373.1 FGFR1c ligand binding and activation REGULATION OF RAS BY GAPS%REACTOME%R-RNO-5658442.1 Regulation of RAS by GAPs RETROGRADE TRANSPORT AT THE TRANS-GOLGI-NETWORK%REACTOME%R-RNO-6811440.1 Retrograde transport at the Trans-Golgi-Network TRANSLOCATION OF SLC2A4 (GLUT4) TO THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 66%10145854 Translocation of SLC2A4 (GLUT4) to the plasma membrane ACTIVATION OF NMDA RECEPTORS AND POSTSYNAPTIC EVENTS%REACTOME%R-RNO-442755.1 Activation of NMDA receptors and postsynaptic events INTERACTION WITH CUMULUS CELLS%REACTOME DATABASE ID RELEASE 66%10145974 Interaction With Cumulus Cells INTERLEUKIN-9 SIGNALING%REACTOME%R-RNO-8985947.1 Interleukin-9 signaling SIGNALING BY NOTCH%REACTOME DATABASE ID RELEASE 66%10145914 Signaling by NOTCH SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE%REACTOME DATABASE ID RELEASE 66%10144727 Switching of origins to a post-replicative state SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA-HYDROXYCHOLESTEROL%REACTOME DATABASE ID RELEASE 66%10145313 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 66%10145498 Semaphorin interactions CREATINE METABOLISM%REACTOME DATABASE ID RELEASE 66%10144813 Creatine metabolism PHOSPHORYLATION OF PROTEINS INVOLVED IN G1 S TRANSITION BY ACTIVE CYCLIN E:CDK2 COMPLEXES%REACTOME DATABASE ID RELEASE 66%10145275 Phosphorylation of proteins involved in G1 S transition by active Cyclin E:Cdk2 complexes INTRINSIC PATHWAY OF FIBRIN CLOT FORMATION%REACTOME DATABASE ID RELEASE 66%10145080 Intrinsic Pathway of Fibrin Clot Formation RUNX1 INTERACTS WITH CO-FACTORS WHOSE PRECISE EFFECT ON RUNX1 TARGETS IS NOT KNOWN%REACTOME%R-RNO-8939243.1 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known SUMO IS TRANSFERRED FROM E1 TO E2 (UBE2I, UBC9)%REACTOME DATABASE ID RELEASE 66%10145988 SUMO is transferred from E1 to E2 (UBE2I, UBC9) VITAMIN D (CALCIFEROL) METABOLISM%REACTOME%R-RNO-196791.1 Vitamin D (calciferol) metabolism ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM%REACTOME%R-RNO-2046104.1 alpha-linolenic (omega3) and linoleic (omega6) acid metabolism KERATAN SULFATE BIOSYNTHESIS%REACTOME%R-RNO-2022854.1 Keratan sulfate biosynthesis ACTIVATION OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 66%10144723 Activation of the pre-replicative complex HCN CHANNELS%REACTOME%R-RNO-1296061.1 HCN channels SUMOYLATION OF DNA REPLICATION PROTEINS%REACTOME%R-RNO-4615885.1 SUMOylation of DNA replication proteins HEDGEHOG 'ON' STATE%REACTOME%R-RNO-5632684.1 Hedgehog 'on' state FRS2-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 66%10145200 Frs2-mediated activation G BETA:GAMMA SIGNALLING THROUGH PLC BETA%REACTOME DATABASE ID RELEASE 66%10145577 G beta:gamma signalling through PLC beta INHIBITION OF TSC COMPLEX FORMATION BY PKB%REACTOME%R-RNO-165181.1 Inhibition of TSC complex formation by PKB NEGATIVE REGULATION OF FGFR1 SIGNALING%REACTOME%R-RNO-5654726.1 Negative regulation of FGFR1 signaling PLASMA LIPOPROTEIN REMODELING%REACTOME%R-RNO-8963899.1 Plasma lipoprotein remodeling AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE%REACTOME%R-RNO-352230.1 Amino acid transport across the plasma membrane APOPTOSIS INDUCED DNA FRAGMENTATION%REACTOME DATABASE ID RELEASE 66%10145440 Apoptosis induced DNA fragmentation NF-KB IS ACTIVATED AND SIGNALS SURVIVAL%REACTOME%R-RNO-209560.1 NF-kB is activated and signals survival CELLULAR RESPONSE TO HEAT STRESS%REACTOME%R-RNO-3371556.1 Cellular response to heat stress TRANSPORT OF NUCLEOTIDE SUGARS%REACTOME%R-RNO-727802.1 Transport of nucleotide sugars SEPARATION OF SISTER CHROMATIDS%REACTOME DATABASE ID RELEASE 66%10145223 Separation of Sister Chromatids GAMMA-CARBOXYLATION OF PROTEIN PRECURSORS%REACTOME%R-RNO-159740.1 Gamma-carboxylation of protein precursors REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND%REACTOME DATABASE ID RELEASE 66%10145237 Removal of the Flap Intermediate from the C-strand SMAC-MEDIATED APOPTOTIC RESPONSE%REACTOME DATABASE ID RELEASE 66%10145021 SMAC-mediated apoptotic response PI-3K CASCADE:FGFR1%REACTOME%R-RNO-5654689.1 PI-3K cascade:FGFR1 METABOLISM OF COFACTORS%REACTOME DATABASE ID RELEASE 66%10145548 Metabolism of cofactors EUKARYOTIC TRANSLATION ELONGATION%REACTOME%R-RNO-156842.1 Eukaryotic Translation Elongation TELOMERE EXTENSION BY TELOMERASE%REACTOME DATABASE ID RELEASE 66%10145110 Telomere Extension By Telomerase SIGNALLING TO ERKS%REACTOME DATABASE ID RELEASE 66%10145182 Signalling to ERKs LAGGING STRAND SYNTHESIS%REACTOME%R-RNO-69186.1 Lagging Strand Synthesis POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS%REACTOME DATABASE ID RELEASE 66%10145102 Post-translational modification: synthesis of GPI-anchored proteins DIGESTION OF DIETARY LIPID%REACTOME%R-RNO-192456.1 Digestion of dietary lipid WNT5A-DEPENDENT INTERNALIZATION OF FZD4%REACTOME DATABASE ID RELEASE 66%10146042 WNT5A-dependent internalization of FZD4 COMMON PATHWAY OF FIBRIN CLOT FORMATION%REACTOME%R-RNO-140875.1 Common Pathway of Fibrin Clot Formation ACYL CHAIN REMODELLING OF PS%REACTOME DATABASE ID RELEASE 66%10145868 Acyl chain remodelling of PS ASSEMBLY OF THE ORC COMPLEX AT THE ORIGIN OF REPLICATION%REACTOME DATABASE ID RELEASE 66%10144712 Assembly of the ORC complex at the origin of replication HSF1 ACTIVATION%REACTOME%R-RNO-3371511.1 HSF1 activation NON-CODING RNA METABOLISM%REACTOME%R-RNO-194441.1 Non-coding RNA Metabolism REGULATION OF TP53 ACTIVITY THROUGH PHOSPHORYLATION%REACTOME DATABASE ID RELEASE 66%10144756 Regulation of TP53 Activity through Phosphorylation MITOCHONDRIAL TRANSLATION TERMINATION%REACTOME DATABASE ID RELEASE 66%10146065 Mitochondrial translation termination CONJUGATION OF CARBOXYLIC ACIDS%REACTOME DATABASE ID RELEASE 66%10145090 Conjugation of carboxylic acids OPSINS%REACTOME%R-RNO-419771.1 Opsins TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES%REACTOME DATABASE ID RELEASE 66%10144951 Transport of vitamins, nucleosides, and related molecules EICOSANOID LIGAND-BINDING RECEPTORS%REACTOME%R-RNO-391903.1 Eicosanoid ligand-binding receptors FRUCTOSE METABOLISM%REACTOME%R-RNO-5652084.1 Fructose metabolism B-WICH COMPLEX POSITIVELY REGULATES RRNA EXPRESSION%REACTOME DATABASE ID RELEASE 66%10146051 B-WICH complex positively regulates rRNA expression PCNA-DEPENDENT LONG PATCH BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 66%10144982 PCNA-Dependent Long Patch Base Excision Repair TNFS BIND THEIR PHYSIOLOGICAL RECEPTORS%REACTOME DATABASE ID RELEASE 66%10146122 TNFs bind their physiological receptors INTERLEUKIN-37 SIGNALING%REACTOME DATABASE ID RELEASE 66%10146292 Interleukin-37 signaling RETROGRADE NEUROTROPHIN SIGNALLING%REACTOME%R-RNO-177504.1 Retrograde neurotrophin signalling PRPP BIOSYNTHESIS%REACTOME%R-RNO-73843.1 PRPP biosynthesis RHO GTPASES ACTIVATE KTN1%REACTOME%R-RNO-5625970.1 RHO GTPases activate KTN1 PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS%REACTOME%R-RNO-202427.1 Phosphorylation of CD3 and TCR zeta chains ACTIVATION OF GABAB RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145188 Activation of GABAB receptors CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS%REACTOME%R-RNO-442742.1 CREB phosphorylation through the activation of Ras ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 66%10145158 Activation of the AP-1 family of transcription factors SYNTHESIS OF DOLICHYL-PHOSPHATE-GLUCOSE%REACTOME DATABASE ID RELEASE 66%10145673 Synthesis of dolichyl-phosphate-glucose PTK6 REGULATES RTKS AND THEIR EFFECTORS AKT1 AND DOK1%REACTOME DATABASE ID RELEASE 66%10146206 PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 COHESIN LOADING ONTO CHROMATIN%REACTOME%R-RNO-2470946.1 Cohesin Loading onto Chromatin SEMA3A PAK DEPENDENT AXON REPULSION%REACTOME DATABASE ID RELEASE 66%10145582 Sema3A PAK dependent Axon repulsion ATTENUATION PHASE%REACTOME DATABASE ID RELEASE 66%10146014 Attenuation phase RNA POLYMERASE II TRANSCRIPTION%REACTOME DATABASE ID RELEASE 66%10144750 RNA Polymerase II Transcription ROLE OF ABL IN ROBO-SLIT SIGNALING%REACTOME%R-RNO-428890.1 Role of ABL in ROBO-SLIT signaling SIGNALING BY FGFR3%REACTOME DATABASE ID RELEASE 66%10145259 Signaling by FGFR3 COLLAGEN FORMATION%REACTOME%R-RNO-1474290.1 Collagen formation DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION%REACTOME%R-RNO-3134963.1 DEx H-box helicases activate type I IFN and inflammatory cytokines production SUMOYLATION OF SUMOYLATION PROTEINS%REACTOME DATABASE ID RELEASE 66%10146029 SUMOylation of SUMOylation proteins REGULATED NECROSIS%REACTOME%R-RNO-5218859.1 Regulated Necrosis SYNTHESIS OF 15-EICOSATETRAENOIC ACID DERIVATIVES%REACTOME DATABASE ID RELEASE 66%10145944 Synthesis of 15-eicosatetraenoic acid derivatives EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA%REACTOME%R-RNO-212718.1 EGFR interacts with phospholipase C-gamma PHOSPHORYLATION OF EMI1%REACTOME DATABASE ID RELEASE 66%10145225 Phosphorylation of Emi1 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY%REACTOME%R-RNO-3301854.1 Nuclear Pore Complex (NPC) Disassembly REPRESSION OF WNT TARGET GENES%REACTOME DATABASE ID RELEASE 66%10146038 Repression of WNT target genes APOPTOTIC EXECUTION PHASE%REACTOME DATABASE ID RELEASE 66%10145388 Apoptotic execution phase RUNX3 REGULATES NOTCH SIGNALING%REACTOME%R-RNO-8941856.1 RUNX3 regulates NOTCH signaling VEGFR2 MEDIATED CELL PROLIFERATION%REACTOME DATABASE ID RELEASE 66%10146032 VEGFR2 mediated cell proliferation NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145596 Nucleotide-like (purinergic) receptors SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 27-HYDROXYCHOLESTEROL%REACTOME%R-RNO-193807.1 Synthesis of bile acids and bile salts via 27-hydroxycholesterol INTEGRIN SIGNALING%REACTOME DATABASE ID RELEASE 66%10145478 Integrin signaling G ALPHA (I) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 66%10144868 G alpha (i) signalling events TRANSMISSION ACROSS CHEMICAL SYNAPSES%REACTOME%R-RNO-112315.1 Transmission across Chemical Synapses FGFR2 LIGAND BINDING AND ACTIVATION%REACTOME%R-RNO-190241.1 FGFR2 ligand binding and activation SIGNALING BY NON-RECEPTOR TYROSINE KINASES%REACTOME DATABASE ID RELEASE 66%10146199 Signaling by Non-Receptor Tyrosine Kinases CARDIAC CONDUCTION%REACTOME%R-RNO-5576891.1 Cardiac conduction TBC RABGAPS%REACTOME DATABASE ID RELEASE 66%10146222 TBC RABGAPs FBXL7 DOWN-REGULATES AURKA DURING MITOTIC ENTRY AND IN EARLY MITOSIS%REACTOME%R-RNO-8854050.1 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis COPI-INDEPENDENT GOLGI-TO-ER RETROGRADE TRAFFIC%REACTOME%R-RNO-6811436.1 COPI-independent Golgi-to-ER retrograde traffic TANDEM PORE DOMAIN HALOTHANE-INHIBITED K+ CHANNEL (THIK)%REACTOME DATABASE ID RELEASE 66%10145843 Tandem pore domain halothane-inhibited K+ channel (THIK) PYROPHOSPHATE HYDROLYSIS%REACTOME%R-RNO-71737.1 Pyrophosphate hydrolysis MITOPHAGY%REACTOME DATABASE ID RELEASE 66%10146046 Mitophagy LYSOSOMAL OLIGOSACCHARIDE CATABOLISM%REACTOME DATABASE ID RELEASE 66%10146170 Lysosomal oligosaccharide catabolism POTASSIUM CHANNELS%REACTOME%R-RNO-1296071.1 Potassium Channels PI3K CASCADE%REACTOME DATABASE ID RELEASE 66%10144954 PI3K Cascade BREAKDOWN OF THE NUCLEAR LAMINA%REACTOME%R-RNO-352238.1 Breakdown of the nuclear lamina ACTIVATION, TRANSLOCATION AND OLIGOMERIZATION OF BAX%REACTOME DATABASE ID RELEASE 66%10145017 Activation, translocation and oligomerization of BAX ENDOSOMAL VACUOLAR PATHWAY%REACTOME%R-RNO-1236977.1 Endosomal Vacuolar pathway ABACAVIR METABOLISM%REACTOME%R-RNO-2161541.1 Abacavir metabolism PROTEIN FOLDING%REACTOME%R-RNO-391251.1 Protein folding ACTIVATION OF BIM AND TRANSLOCATION TO MITOCHONDRIA%REACTOME DATABASE ID RELEASE 66%10145048 Activation of BIM and translocation to mitochondria SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION%REACTOME%R-RNO-399955.1 SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion SIGNALING BY NTRKS%REACTOME%R-RNO-166520.1 Signaling by NTRKs HUR (ELAVL1) BINDS AND STABILIZES MRNA%REACTOME DATABASE ID RELEASE 66%10145693 HuR (ELAVL1) binds and stabilizes mRNA INTESTINAL LIPID ABSORPTION%REACTOME DATABASE ID RELEASE 66%10145460 Intestinal lipid absorption RNA POLYMERASE I PROMOTER OPENING%REACTOME DATABASE ID RELEASE 66%10144847 RNA Polymerase I Promoter Opening INTEGRIN CELL SURFACE INTERACTIONS%REACTOME%R-RNO-216083.1 Integrin cell surface interactions TNFR2 NON-CANONICAL NF-KB PATHWAY%REACTOME DATABASE ID RELEASE 66%10145373 TNFR2 non-canonical NF-kB pathway N-GLYCAN TRIMMING AND ELONGATION IN THE CIS-GOLGI%REACTOME DATABASE ID RELEASE 66%10145771 N-glycan trimming and elongation in the cis-Golgi FRS-MEDIATED FGFR4 SIGNALING%REACTOME DATABASE ID RELEASE 66%10146106 FRS-mediated FGFR4 signaling G-PROTEIN ACTIVATION%REACTOME%R-RNO-202040.1 G-protein activation OXIDATIVE STRESS INDUCED SENESCENCE%REACTOME DATABASE ID RELEASE 66%10145165 Oxidative Stress Induced Senescence TACHYKININ RECEPTORS BIND TACHYKININS%REACTOME DATABASE ID RELEASE 66%10145521 Tachykinin receptors bind tachykinins GLOBAL GENOME NUCLEOTIDE EXCISION REPAIR (GG-NER)%REACTOME%R-RNO-5696399.1 Global Genome Nucleotide Excision Repair (GG-NER) CENTROSOME MATURATION%REACTOME%R-RNO-380287.1 Centrosome maturation CHROMATIN ORGANIZATION%REACTOME DATABASE ID RELEASE 66%10145803 Chromatin organization EXTENSION OF TELOMERES%REACTOME DATABASE ID RELEASE 66%10145111 Extension of Telomeres CDO IN MYOGENESIS%REACTOME DATABASE ID RELEASE 66%10145503 CDO in myogenesis GAP JUNCTION TRAFFICKING AND REGULATION%REACTOME DATABASE ID RELEASE 66%10145298 Gap junction trafficking and regulation GLUTATHIONE SYNTHESIS AND RECYCLING%REACTOME%R-RNO-174403.1 Glutathione synthesis and recycling INTERLEUKIN-3, INTERLEUKIN-5 AND GM-CSF SIGNALING%REACTOME DATABASE ID RELEASE 66%10145705 Interleukin-3, Interleukin-5 and GM-CSF signaling ACYL CHAIN REMODELLING OF PC%REACTOME%R-RNO-1482788.1 Acyl chain remodelling of PC INTERLEUKIN-1 SIGNALING%REACTOME%R-RNO-9020702.1 Interleukin-1 signaling G0 AND EARLY G1%REACTOME%R-RNO-1538133.1 G0 and Early G1 ACTIVATION OF CAMK IV%REACTOME%R-RNO-442745.1 Activation of CaMK IV ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%R-RNO-1296041.1 Activation of G protein gated Potassium channels DUAL INCISION IN TC-NER%REACTOME%R-RNO-6782135.1 Dual incision in TC-NER CYTOSOLIC TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 66%10144822 Cytosolic tRNA aminoacylation ELECTRON TRANSPORT FROM NADPH TO FERREDOXIN%REACTOME%R-RNO-2395516.1 Electron transport from NADPH to Ferredoxin VEGF LIGAND-RECEPTOR INTERACTIONS%REACTOME DATABASE ID RELEASE 66%10145339 VEGF ligand-receptor interactions YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION%REACTOME%R-RNO-2032785.1 YAP1- and WWTR1 (TAZ)-stimulated gene expression DNA REPAIR%REACTOME DATABASE ID RELEASE 66%10144763 DNA Repair REGULATION OF NECROPTOTIC CELL DEATH%REACTOME DATABASE ID RELEASE 66%10146017 Regulation of necroptotic cell death INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1%REACTOME DATABASE ID RELEASE 66%10145013 Inhibition of replication initiation of damaged DNA by RB1 E2F1 RECOGNITION OF DNA DAMAGE BY PCNA-CONTAINING REPLICATION COMPLEX%REACTOME DATABASE ID RELEASE 66%10146094 Recognition of DNA damage by PCNA-containing replication complex SYNAPTIC ADHESION-LIKE MOLECULES%REACTOME DATABASE ID RELEASE 66%10146209 Synaptic adhesion-like molecules VEGF BINDS TO VEGFR LEADING TO RECEPTOR DIMERIZATION%REACTOME DATABASE ID RELEASE 66%10145338 VEGF binds to VEGFR leading to receptor dimerization THE ACTIVATION OF ARYLSULFATASES%REACTOME DATABASE ID RELEASE 66%10145887 The activation of arylsulfatases LINOLEIC ACID (LA) METABOLISM%REACTOME DATABASE ID RELEASE 66%10145933 Linoleic acid (LA) metabolism FORMATION OF ANNULAR GAP JUNCTIONS%REACTOME%R-RNO-196025.1 Formation of annular gap junctions CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM%REACTOME DATABASE ID RELEASE 66%10145886 Chondroitin sulfate dermatan sulfate metabolism INTERLEUKIN-12 FAMILY SIGNALING%REACTOME%R-RNO-447115.1 Interleukin-12 family signaling TOLL LIKE RECEPTOR 10 (TLR10) CASCADE%REACTOME%R-RNO-168142.1 Toll Like Receptor 10 (TLR10) Cascade BIOSYNTHESIS OF ASPIRIN-TRIGGERED D-SERIES RESOLVINS%REACTOME%R-RNO-9020265.1 Biosynthesis of aspirin-triggered D-series resolvins ADENYLATE CYCLASE INHIBITORY PATHWAY%REACTOME DATABASE ID RELEASE 66%10145186 Adenylate cyclase inhibitory pathway HYDROLYSIS OF LPC%REACTOME%R-RNO-1483115.1 Hydrolysis of LPC PRE-NOTCH EXPRESSION AND PROCESSING%REACTOME DATABASE ID RELEASE 66%10145916 Pre-NOTCH Expression and Processing CD22 MEDIATED BCR REGULATION%REACTOME DATABASE ID RELEASE 66%10146141 CD22 mediated BCR regulation ACTIVATION OF NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%R-RNO-629602.1 Activation of Nicotinic Acetylcholine Receptors TRANSCRIPTION FROM MITOCHONDRIAL PROMOTERS%REACTOME DATABASE ID RELEASE 66%10145118 Transcription from mitochondrial promoters DOPAMINE RECEPTORS%REACTOME%R-RNO-390651.1 Dopamine receptors SYNTHESIS OF EPOXY (EET) AND DIHYDROXYEICOSATRIENOIC ACIDS (DHET)%REACTOME DATABASE ID RELEASE 66%10145947 Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK%REACTOME DATABASE ID RELEASE 66%10145383 Energy dependent regulation of mTOR by LKB1-AMPK BIOSYNTHESIS OF E-SERIES 18(S)-RESOLVINS%REACTOME%R-RNO-9018896.1 Biosynthesis of E-series 18(S)-resolvins SYNTHESIS OF PA%REACTOME DATABASE ID RELEASE 66%10144907 Synthesis of PA NOSTRIN MEDIATED ENOS TRAFFICKING%REACTOME%R-RNO-203641.1 NOSTRIN mediated eNOS trafficking DEPYRIMIDINATION%REACTOME DATABASE ID RELEASE 66%10144972 Depyrimidination PHYSIOLOGICAL FACTORS%REACTOME%R-RNO-5578768.1 Physiological factors JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1%REACTOME%R-RNO-450321.1 JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 DNA STRAND ELONGATION%REACTOME%R-RNO-69190.1 DNA strand elongation INTERFERON ALPHA BETA SIGNALING%REACTOME%R-RNO-909733.1 Interferon alpha beta signaling TOLL-LIKE RECEPTOR CASCADES%REACTOME DATABASE ID RELEASE 66%10145131 Toll-like Receptor Cascades RESOLUTION OF SISTER CHROMATID COHESION%REACTOME DATABASE ID RELEASE 66%10145894 Resolution of Sister Chromatid Cohesion GPVI-MEDIATED ACTIVATION CASCADE%REACTOME%R-RNO-114604.1 GPVI-mediated activation cascade NADE MODULATES DEATH SIGNALLING%REACTOME DATABASE ID RELEASE 66%10145330 NADE modulates death signalling RHO GTPASES ACTIVATE RHOTEKIN AND RHOPHILINS%REACTOME DATABASE ID RELEASE 66%10146121 RHO GTPases Activate Rhotekin and Rhophilins PROSTANOID LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145568 Prostanoid ligand receptors PACKAGING OF TELOMERE ENDS%REACTOME%R-RNO-171306.1 Packaging Of Telomere Ends ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING%REACTOME DATABASE ID RELEASE 66%10145740 Advanced glycosylation endproduct receptor signaling TP53 REGULATES TRANSCRIPTION OF CELL DEATH GENES%REACTOME%R-RNO-5633008.1 TP53 Regulates Transcription of Cell Death Genes FGFR2C LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 66%10145288 FGFR2c ligand binding and activation PLASMA LIPOPROTEIN ASSEMBLY%REACTOME%R-RNO-8963898.1 Plasma lipoprotein assembly ACTIVATED NTRK2 SIGNALS THROUGH FRS2 AND FRS3%REACTOME%R-RNO-9028731.1 Activated NTRK2 signals through FRS2 and FRS3 E2F MEDIATED REGULATION OF DNA REPLICATION%REACTOME DATABASE ID RELEASE 66%10145014 E2F mediated regulation of DNA replication TOLL LIKE RECEPTOR 2 (TLR2) CASCADE%REACTOME%R-RNO-181438.1 Toll Like Receptor 2 (TLR2) Cascade TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION%REACTOME%R-RNO-1474151.1 Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation RHO GTPASES ACTIVATE NADPH OXIDASES%REACTOME DATABASE ID RELEASE 66%10146047 RHO GTPases Activate NADPH Oxidases DOWNREGULATION OF ERBB2:ERBB3 SIGNALING%REACTOME%R-RNO-1358803.1 Downregulation of ERBB2:ERBB3 signaling CELL-CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 66%10145495 Cell-cell junction organization SYNTHESIS OF IPS IN THE NUCLEUS%REACTOME%R-RNO-1855191.1 Synthesis of IPs in the nucleus SYNTHESIS OF DNA%REACTOME DATABASE ID RELEASE 66%10144719 Synthesis of DNA SYNTHESIS OF BILE ACIDS AND BILE SALTS%REACTOME DATABASE ID RELEASE 66%10145312 Synthesis of bile acids and bile salts APOPTOTIC FACTOR-MEDIATED RESPONSE%REACTOME%R-RNO-111471.1 Apoptotic factor-mediated response GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT%REACTOME%R-RNO-72706.1 GTP hydrolysis and joining of the 60S ribosomal subunit INTRA-GOLGI AND RETROGRADE GOLGI-TO-ER TRAFFIC%REACTOME DATABASE ID RELEASE 66%10146192 Intra-Golgi and retrograde Golgi-to-ER traffic SIGNALING BY RECEPTOR TYROSINE KINASES%REACTOME DATABASE ID RELEASE 66%10144877 Signaling by Receptor Tyrosine Kinases TRANS-GOLGI NETWORK VESICLE BUDDING%REACTOME DATABASE ID RELEASE 66%10145468 trans-Golgi Network Vesicle Budding LIGAND-INDEPENDENT CASPASE ACTIVATION VIA DCC%REACTOME DATABASE ID RELEASE 66%10145489 Ligand-independent caspase activation via DCC IONOTROPIC ACTIVITY OF KAINATE RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145699 Ionotropic activity of kainate receptors SMAC-MEDIATED DISSOCIATION OF IAP:CASPASE COMPLEXES%REACTOME%R-RNO-111464.1 SMAC-mediated dissociation of IAP:caspase complexes MITOTIC G1-G1 S PHASES%REACTOME DATABASE ID RELEASE 66%10144725 Mitotic G1-G1 S phases HEME DEGRADATION%REACTOME%R-RNO-189483.1 Heme degradation BIOSYNTHESIS OF DPAN-3-DERIVED MARESINS%REACTOME%R-RNO-9026290.1 Biosynthesis of DPAn-3-derived maresins TP53 REGULATES TRANSCRIPTION OF ADDITIONAL CELL CYCLE GENES WHOSE EXACT ROLE IN THE P53 PATHWAY REMAIN UNCERTAIN%REACTOME%R-RNO-6804115.1 TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain FGFR3 LIGAND BINDING AND ACTIVATION%REACTOME%R-RNO-190239.1 FGFR3 ligand binding and activation MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 66%10145043 Muscle contraction DEATH RECEPTOR SIGNALLING%REACTOME DATABASE ID RELEASE 66%10144808 Death Receptor Signalling DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR)%REACTOME DATABASE ID RELEASE 66%10145798 Downstream signaling events of B Cell Receptor (BCR) TNFR1-INDUCED PROAPOPTOTIC SIGNALING%REACTOME DATABASE ID RELEASE 66%10144945 TNFR1-induced proapoptotic signaling KSRP (KHSRP) BINDS AND DESTABILIZES MRNA%REACTOME DATABASE ID RELEASE 66%10145696 KSRP (KHSRP) binds and destabilizes mRNA BIOSYNTHESIS OF PROTECTINS%REACTOME%R-RNO-9018681.1 Biosynthesis of protectins SIGNALING BY ERYTHROPOIETIN%REACTOME DATABASE ID RELEASE 66%10146295 Signaling by Erythropoietin DISINHIBITION OF SNARE FORMATION%REACTOME DATABASE ID RELEASE 66%10145035 Disinhibition of SNARE formation CATECHOLAMINE BIOSYNTHESIS%REACTOME%R-RNO-209905.1 Catecholamine biosynthesis TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES%REACTOME%R-RNO-425393.1 Transport of inorganic cations anions and amino acids oligopeptides SIGNAL ATTENUATION%REACTOME%R-RNO-74749.1 Signal attenuation NONHOMOLOGOUS END-JOINING (NHEJ)%REACTOME%R-RNO-5693571.1 Nonhomologous End-Joining (NHEJ) BASIGIN INTERACTIONS%REACTOME%R-RNO-210991.1 Basigin interactions SUMO IS CONJUGATED TO E1 (UBA2:SAE1)%REACTOME DATABASE ID RELEASE 66%10145983 SUMO is conjugated to E1 (UBA2:SAE1) NUCLEAR SIGNALING BY ERBB4%REACTOME%R-RNO-1251985.1 Nuclear signaling by ERBB4 LIPOPROTEIN METABOLISM%REACTOME DATABASE ID RELEASE 66%10145205 Lipoprotein metabolism CA ACTIVATED K+ CHANNELS%REACTOME DATABASE ID RELEASE 66%10145832 Ca activated K+ channels SYNTHESIS OF IPS IN THE ER LUMEN%REACTOME%R-RNO-1855231.1 Synthesis of IPs in the ER lumen LEUKOTRIENE RECEPTORS%REACTOME%R-RNO-391906.1 Leukotriene receptors CELL JUNCTION ORGANIZATION%REACTOME%R-RNO-446728.1 Cell junction organization PHOSPHORYLATION OF THE APC C%REACTOME DATABASE ID RELEASE 66%10145220 Phosphorylation of the APC C ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY%REACTOME DATABASE ID RELEASE 66%10145655 Zinc influx into cells by the SLC39 gene family P75 NTR RECEPTOR-MEDIATED SIGNALLING%REACTOME%R-RNO-193704.1 p75 NTR receptor-mediated signalling METABOLISM%REACTOME DATABASE ID RELEASE 66%10144767 Metabolism XBP1(S) ACTIVATES CHAPERONE GENES%REACTOME%R-RNO-381038.1 XBP1(S) activates chaperone genes COPI-MEDIATED ANTEROGRADE TRANSPORT%REACTOME%R-RNO-6807878.1 COPI-mediated anterograde transport INTERLEUKIN-12 SIGNALING%REACTOME DATABASE ID RELEASE 66%10145676 Interleukin-12 signaling NONSENSE-MEDIATED DECAY (NMD)%REACTOME%R-RNO-927802.1 Nonsense-Mediated Decay (NMD) REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE%REACTOME%R-RNO-3371453.1 Regulation of HSF1-mediated heat shock response TRANSCRIPTIONAL REGULATION BY TP53%REACTOME DATABASE ID RELEASE 66%10144748 Transcriptional Regulation by TP53 ROBO RECEPTORS BIND AKAP5%REACTOME%R-RNO-9010642.1 ROBO receptors bind AKAP5 INTERLEUKIN-35 SIGNALLING%REACTOME DATABASE ID RELEASE 66%10145680 Interleukin-35 Signalling TRANSLATION%REACTOME%R-RNO-72766.1 Translation TP53 REGULATES TRANSCRIPTION OF CASPASE ACTIVATORS AND CASPASES%REACTOME%R-RNO-6803207.1 TP53 Regulates Transcription of Caspase Activators and Caspases VISUAL PHOTOTRANSDUCTION%REACTOME%R-RNO-2187338.1 Visual phototransduction ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS%REACTOME DATABASE ID RELEASE 66%10145358 Role of phospholipids in phagocytosis TRAF6-MEDIATED INDUCTION OF TAK1 COMPLEX WITHIN TLR4 COMPLEX%REACTOME DATABASE ID RELEASE 66%10145767 TRAF6-mediated induction of TAK1 complex within TLR4 complex TRKA ACTIVATION BY NGF%REACTOME DATABASE ID RELEASE 66%10145140 TRKA activation by NGF AQUAPORIN-MEDIATED TRANSPORT%REACTOME DATABASE ID RELEASE 66%10145007 Aquaporin-mediated transport CHK1 CHK2(CDS1) MEDIATED INACTIVATION OF CYCLIN B:CDK1 COMPLEX%REACTOME%R-RNO-75035.1 Chk1 Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex NEURONAL SYSTEM%REACTOME DATABASE ID RELEASE 66%10144791 Neuronal System SIGNAL REGULATORY PROTEIN FAMILY INTERACTIONS%REACTOME DATABASE ID RELEASE 66%10145430 Signal regulatory protein family interactions RHO GTPASES ACTIVATE ROCKS%REACTOME%R-RNO-5627117.1 RHO GTPases Activate ROCKs TRIF(TICAM1)-MEDIATED TLR4 SIGNALING%REACTOME DATABASE ID RELEASE 66%10145138 TRIF(TICAM1)-mediated TLR4 signaling REGULATION OF TP53 DEGRADATION%REACTOME DATABASE ID RELEASE 66%10145361 Regulation of TP53 Degradation VITAMIN B1 (THIAMIN) METABOLISM%REACTOME%R-RNO-196819.1 Vitamin B1 (thiamin) metabolism E3 UBIQUITIN LIGASES UBIQUITINATE TARGET PROTEINS%REACTOME%R-RNO-8866654.1 E3 ubiquitin ligases ubiquitinate target proteins RESOLUTION OF D-LOOP STRUCTURES THROUGH SYNTHESIS-DEPENDENT STRAND ANNEALING (SDSA)%REACTOME DATABASE ID RELEASE 66%10146147 Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) TWIK RELATED POTASSIUM CHANNEL (TREK)%REACTOME DATABASE ID RELEASE 66%10145838 TWIK related potassium channel (TREK) REGULATION OF BETA-CELL DEVELOPMENT%REACTOME DATABASE ID RELEASE 66%10145438 Regulation of beta-cell development PROCESSIVE SYNTHESIS ON THE LAGGING STRAND%REACTOME%R-RNO-69183.1 Processive synthesis on the lagging strand CARBOXYTERMINAL POST-TRANSLATIONAL MODIFICATIONS OF TUBULIN%REACTOME%R-RNO-8955332.1 Carboxyterminal post-translational modifications of tubulin APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME DATABASE ID RELEASE 66%10145218 APC C:Cdc20 mediated degradation of mitotic proteins DEGRADATION OF AXIN%REACTOME DATABASE ID RELEASE 66%10146020 Degradation of AXIN DNA DAMAGE BYPASS%REACTOME DATABASE ID RELEASE 66%10144978 DNA Damage Bypass SIGNALING BY ACTIVIN%REACTOME%R-RNO-1502540.1 Signaling by Activin CELL DIVISION%REACTOME%R-RNO-68884.1 cell division OAS ANTIVIRAL RESPONSE%REACTOME DATABASE ID RELEASE 66%10146284 OAS antiviral response PKA-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%R-RNO-111931.1 PKA-mediated phosphorylation of CREB RHO GTPASES ACTIVATE WASPS AND WAVES%REACTOME DATABASE ID RELEASE 66%10145928 RHO GTPases Activate WASPs and WAVEs SNRNP ASSEMBLY%REACTOME%R-RNO-191859.1 snRNP Assembly CHROMOSOME MAINTENANCE%REACTOME DATABASE ID RELEASE 66%10145113 Chromosome Maintenance TRANSCRIPTIONAL REGULATION BY RUNX1%REACTOME DATABASE ID RELEASE 66%10146236 Transcriptional regulation by RUNX1 AFLATOXIN ACTIVATION AND DETOXIFICATION%REACTOME DATABASE ID RELEASE 66%10145070 Aflatoxin activation and detoxification SEROTONIN AND MELATONIN BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 66%10145426 Serotonin and melatonin biosynthesis N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI%REACTOME%R-RNO-975576.1 N-glycan antennae elongation in the medial trans-Golgi HYDROLYSIS OF LPE%REACTOME%R-RNO-1483152.1 Hydrolysis of LPE ACTIVATED NTRK3 SIGNALS THROUGH PI3K%REACTOME%R-RNO-9603381.1 Activated NTRK3 signals through PI3K SIGNAL TRANSDUCTION BY L1%REACTOME%R-RNO-445144.1 Signal transduction by L1 PDE3B SIGNALLING%REACTOME%R-RNO-165160.1 PDE3B signalling IRS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 66%10144880 IRS-mediated signalling TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE%REACTOME DATABASE ID RELEASE 66%10145154 Toll Like Receptor 7 8 (TLR7 8) Cascade ATP SENSITIVE POTASSIUM CHANNELS%REACTOME DATABASE ID RELEASE 66%10145831 ATP sensitive Potassium channels COOPERATION OF PDCL (PHLP1) AND TRIC CCT IN G-PROTEIN BETA FOLDING%REACTOME DATABASE ID RELEASE 66%10146196 Cooperation of PDCL (PhLP1) and TRiC CCT in G-protein beta folding NRIF SIGNALS CELL DEATH FROM THE NUCLEUS%REACTOME DATABASE ID RELEASE 66%10145334 NRIF signals cell death from the nucleus CD209 (DC-SIGN) SIGNALING%REACTOME%R-RNO-5621575.1 CD209 (DC-SIGN) signaling ANTIMICROBIAL PEPTIDES%REACTOME%R-RNO-6803157.1 Antimicrobial peptides VITAMIN C (ASCORBATE) METABOLISM%REACTOME DATABASE ID RELEASE 66%10145368 Vitamin C (ascorbate) metabolism DEUBIQUITINATION%REACTOME DATABASE ID RELEASE 66%10145726 Deubiquitination AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS%REACTOME DATABASE ID RELEASE 66%10145371 AKT phosphorylates targets in the nucleus INFLAMMASOMES%REACTOME DATABASE ID RELEASE 66%10145733 Inflammasomes PROCESSING OF SMDT1%REACTOME%R-RNO-8949664.1 Processing of SMDT1 COPII-MEDIATED VESICLE TRANSPORT%REACTOME%R-RNO-204005.1 COPII-mediated vesicle transport IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME DATABASE ID RELEASE 66%10145773 IRAK2 mediated activation of TAK1 complex upon TLR7 8 or 9 stimulation BIOSYNTHESIS OF DPAN-3 SPMS%REACTOME%R-RNO-9025094.1 Biosynthesis of DPAn-3 SPMs SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS%REACTOME DATABASE ID RELEASE 66%10144939 SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE%REACTOME%R-RNO-4641262.1 Disassembly of the destruction complex and recruitment of AXIN to the membrane COLLAGEN DEGRADATION%REACTOME DATABASE ID RELEASE 66%10145855 Collagen degradation PROTEIN REPAIR%REACTOME%R-RNO-5676934.1 Protein repair ACROSOME REACTION%REACTOME%R-RNO-1300645.1 Acrosome Reaction PKA ACTIVATION%REACTOME%R-RNO-163615.1 PKA activation PROCESSING OF INTRONLESS PRE-MRNAS%REACTOME DATABASE ID RELEASE 66%10144941 Processing of Intronless Pre-mRNAs NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 66%10145491 Netrin-1 signaling FMO OXIDISES NUCLEOPHILES%REACTOME%R-RNO-217271.1 FMO oxidises nucleophiles ASTROCYTIC GLUTAMATE-GLUTAMINE UPTAKE AND METABOLISM%REACTOME%R-RNO-210455.1 Astrocytic Glutamate-Glutamine Uptake And Metabolism RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES%REACTOME%R-RNO-380270.1 Recruitment of mitotic centrosome proteins and complexes METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS%REACTOME%R-RNO-196849.1 Metabolism of water-soluble vitamins and cofactors CELLULAR RESPONSE TO HYPOXIA%REACTOME%R-RNO-2262749.1 Cellular response to hypoxia PHOSPHOLIPASE C-MEDIATED CASCADE; FGFR4%REACTOME DATABASE ID RELEASE 66%10146101 Phospholipase C-mediated cascade; FGFR4 CROSSLINKING OF COLLAGEN FIBRILS%REACTOME DATABASE ID RELEASE 66%10145923 Crosslinking of collagen fibrils CELL SURFACE INTERACTIONS AT THE VASCULAR WALL%REACTOME DATABASE ID RELEASE 66%10145033 Cell surface interactions at the vascular wall FORMATION OF THE EDITOSOME%REACTOME DATABASE ID RELEASE 66%10144942 Formation of the Editosome ACTIVATION OF NOXA AND TRANSLOCATION TO MITOCHONDRIA%REACTOME DATABASE ID RELEASE 66%10145050 Activation of NOXA and translocation to mitochondria REGULATION OF THYROID HORMONE ACTIVITY%REACTOME DATABASE ID RELEASE 66%10145423 Regulation of thyroid hormone activity SODIUM-COUPLED SULPHATE, DI- AND TRI-CARBOXYLATE TRANSPORTERS%REACTOME DATABASE ID RELEASE 66%10145648 Sodium-coupled sulphate, di- and tri-carboxylate transporters APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1%REACTOME%R-RNO-174178.1 APC C:Cdh1 mediated degradation of Cdc20 and other APC C:Cdh1 targeted proteins in late mitosis early G1 BIOSYNTHESIS OF DPAN-3-DERIVED 13-SERIES RESOLVINS%REACTOME%R-RNO-9026403.1 Biosynthesis of DPAn-3-derived 13-series resolvins TP53 REGULATES TRANSCRIPTION OF DEATH RECEPTORS AND LIGANDS%REACTOME%R-RNO-6803211.1 TP53 Regulates Transcription of Death Receptors and Ligands O2 CO2 EXCHANGE IN ERYTHROCYTES%REACTOME DATABASE ID RELEASE 66%10145818 O2 CO2 exchange in erythrocytes FGFR2B LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 66%10145290 FGFR2b ligand binding and activation RAF ACTIVATION%REACTOME DATABASE ID RELEASE 66%10146124 RAF activation ARMS-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 66%10145180 ARMS-mediated activation GRB2 EVENTS IN EGFR SIGNALING%REACTOME%R-RNO-179812.1 GRB2 events in EGFR signaling HS-GAG BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 66%10145730 HS-GAG biosynthesis STAT6-MEDIATED INDUCTION OF CHEMOKINES%REACTOME%R-RNO-3249367.1 STAT6-mediated induction of chemokines DEGRADATION OF GABA%REACTOME DATABASE ID RELEASE 66%10145745 Degradation of GABA BIOSYNTHESIS OF E-SERIES 18(R)-RESOLVINS%REACTOME DATABASE ID RELEASE 66%10146300 Biosynthesis of E-series 18(R)-resolvins DNA DOUBLE STRAND BREAK RESPONSE%REACTOME%R-RNO-5693606.1 DNA Double Strand Break Response REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN%REACTOME DATABASE ID RELEASE 66%10145192 Regulation of Glucokinase by Glucokinase Regulatory Protein CYTOSOLIC SULFONATION OF SMALL MOLECULES%REACTOME%R-RNO-156584.1 Cytosolic sulfonation of small molecules CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS%REACTOME%R-RNO-264870.1 Caspase-mediated cleavage of cytoskeletal proteins DISPLACEMENT OF DNA GLYCOSYLASE BY APEX1%REACTOME%R-RNO-110357.1 Displacement of DNA glycosylase by APEX1 NICOTINAMIDE SALVAGING%REACTOME%R-RNO-197264.1 Nicotinamide salvaging TELOMERE MAINTENANCE%REACTOME DATABASE ID RELEASE 66%10145112 Telomere Maintenance RECYCLING OF EIF2:GDP%REACTOME%R-RNO-72731.1 Recycling of eIF2:GDP CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE%REACTOME DATABASE ID RELEASE 66%10144920 Cytochrome P450 - arranged by substrate type UB-SPECIFIC PROCESSING PROTEASES%REACTOME%R-RNO-5689880.1 Ub-specific processing proteases O-GLYCOSYLATION OF TSR DOMAIN-CONTAINING PROTEINS%REACTOME DATABASE ID RELEASE 66%10146044 O-glycosylation of TSR domain-containing proteins TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT%REACTOME DATABASE ID RELEASE 66%10144895 Transport of Mature mRNA derived from an Intron-Containing Transcript MET ACTIVATES PI3K AKT SIGNALING%REACTOME%R-RNO-8851907.1 MET activates PI3K AKT signaling NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME DATABASE ID RELEASE 66%10145957 NOTCH2 intracellular domain regulates transcription RET SIGNALING%REACTOME DATABASE ID RELEASE 66%10146221 RET signaling CLATHRIN-MEDIATED ENDOCYTOSIS%REACTOME DATABASE ID RELEASE 66%10146228 Clathrin-mediated endocytosis FGFR2 ALTERNATIVE SPLICING%REACTOME%R-RNO-6803529.1 FGFR2 alternative splicing NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME DATABASE ID RELEASE 66%10145624 Negative epigenetic regulation of rRNA expression C-TYPE LECTIN RECEPTORS (CLRS)%REACTOME%R-RNO-5621481.1 C-type lectin receptors (CLRs) TRANSPORT OF CONNEXINS ALONG THE SECRETORY PATHWAY%REACTOME DATABASE ID RELEASE 66%215126 Transport of connexins along the secretory pathway BICARBONATE TRANSPORTERS%REACTOME DATABASE ID RELEASE 66%10145616 Bicarbonate transporters HEMOSTASIS%REACTOME DATABASE ID RELEASE 66%10145028 Hemostasis BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS%REACTOME%R-RNO-111453.1 BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members POSITIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%R-RNO-5250913.1 Positive epigenetic regulation of rRNA expression DEGRADATION OF CYSTEINE AND HOMOCYSTEINE%REACTOME DATABASE ID RELEASE 66%10145890 Degradation of cysteine and homocysteine TRANSPORT OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 66%10144953 Transport of small molecules INTERLEUKIN-1 PROCESSING%REACTOME%R-RNO-448706.1 Interleukin-1 processing FC EPSILON RECEPTOR (FCERI) SIGNALING%REACTOME DATABASE ID RELEASE 66%10145167 Fc epsilon receptor (FCERI) signaling SEROTONIN RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145563 Serotonin receptors REVERSAL OF ALKYLATION DAMAGE BY DNA DIOXYGENASES%REACTOME DATABASE ID RELEASE 66%10146230 Reversal of alkylation damage by DNA dioxygenases PROTEIN-PROTEIN INTERACTIONS AT SYNAPSES%REACTOME%R-RNO-6794362.1 Protein-protein interactions at synapses MET PROMOTES CELL MOTILITY%REACTOME DATABASE ID RELEASE 66%10146247 MET promotes cell motility MRNA EDITING: C TO U CONVERSION%REACTOME%R-RNO-72200.1 mRNA Editing: C to U Conversion ECM PROTEOGLYCANS%REACTOME%R-RNO-3000178.1 ECM proteoglycans P38MAPK EVENTS%REACTOME DATABASE ID RELEASE 66%10145201 p38MAPK events INNATE IMMUNE SYSTEM%REACTOME%R-RNO-168249.1 Innate Immune System TRANSMISSION ACROSS ELECTRICAL SYNAPSES%REACTOME DATABASE ID RELEASE 66%10145508 Transmission across Electrical Synapses EPHA-MEDIATED GROWTH CONE COLLAPSE%REACTOME DATABASE ID RELEASE 66%10146028 EPHA-mediated growth cone collapse IRF3 MEDIATED ACTIVATION OF TYPE 1 IFN%REACTOME%R-RNO-1606341.1 IRF3 mediated activation of type 1 IFN HDL REMODELING%REACTOME DATABASE ID RELEASE 66%10145453 HDL remodeling SIGNALING BY GPCR%REACTOME DATABASE ID RELEASE 66%10144870 Signaling by GPCR ELASTIC FIBRE FORMATION%REACTOME%R-RNO-1566948.1 Elastic fibre formation FGFR4 LIGAND BINDING AND ACTIVATION%REACTOME%R-RNO-190322.1 FGFR4 ligand binding and activation INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION%REACTOME%R-RNO-400508.1 Incretin synthesis, secretion, and inactivation METALLOTHIONEINS BIND METALS%REACTOME%R-RNO-5661231.1 Metallothioneins bind metals INSULIN PROCESSING%REACTOME DATABASE ID RELEASE 66%10145456 Insulin processing ANCHORING FIBRIL FORMATION%REACTOME%R-RNO-2214320.1 Anchoring fibril formation MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF UNSATURATED FATTY ACIDS%REACTOME DATABASE ID RELEASE 66%10144949 mitochondrial fatty acid beta-oxidation of unsaturated fatty acids SCAVENGING BY CLASS A RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145956 Scavenging by Class A Receptors CLATHRIN DERIVED VESICLE BUDDING%REACTOME%R-RNO-421837.1 Clathrin derived vesicle budding SCAVENGING BY CLASS H RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145959 Scavenging by Class H Receptors POLB-DEPENDENT LONG PATCH BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 66%10146093 POLB-Dependent Long Patch Base Excision Repair MACROAUTOPHAGY%REACTOME%R-RNO-1632852.1 Macroautophagy GOLGI ASSOCIATED VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 66%10145614 Golgi Associated Vesicle Biogenesis HEDGEHOG LIGAND BIOGENESIS%REACTOME%R-RNO-5358346.1 Hedgehog ligand biogenesis SIGNALING BY NTRK3 (TRKC)%REACTOME DATABASE ID RELEASE 66%10146326 Signaling by NTRK3 (TRKC) SIGNALING BY NTRK2 (TRKB)%REACTOME DATABASE ID RELEASE 66%10146316 Signaling by NTRK2 (TRKB) NEGATIVE REGULATION OF NOTCH4 SIGNALING%REACTOME DATABASE ID RELEASE 66%10146331 Negative regulation of NOTCH4 signaling ERBB2 ACTIVATES PTK6 SIGNALING%REACTOME%R-RNO-8847993.1 ERBB2 Activates PTK6 Signaling WNT MEDIATED ACTIVATION OF DVL%REACTOME DATABASE ID RELEASE 66%10145393 WNT mediated activation of DVL DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY%REACTOME%R-RNO-2173795.1 Downregulation of SMAD2 3:SMAD4 transcriptional activity REGULATION OF IGF ACTIVITY BY IGFBP%REACTOME%R-RNO-381426.1 Regulation of IGF Activity by IGFBP EUKARYOTIC TRANSLATION TERMINATION%REACTOME DATABASE ID RELEASE 66%10146146 Eukaryotic Translation Termination ACTIVATED NTRK3 SIGNALS THROUGH PLCG1%REACTOME DATABASE ID RELEASE 66%10146327 Activated NTRK3 signals through PLCG1 THE NLRP1 INFLAMMASOME%REACTOME DATABASE ID RELEASE 66%10145732 The NLRP1 inflammasome SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP)%REACTOME%R-RNO-400511.1 Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER%REACTOME%R-RNO-76061.1 RNA Polymerase III Transcription Initiation From Type 1 Promoter TRANSCRIPTIONAL REGULATION BY MECP2%REACTOME%R-RNO-8986944.1 Transcriptional Regulation by MECP2 MITOCHONDRIAL TRANSLATION%REACTOME%R-RNO-5368287.1 Mitochondrial translation PROTEIN LOCALIZATION%REACTOME DATABASE ID RELEASE 66%10146283 Protein localization CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX%REACTOME%R-RNO-68689.1 CDC6 association with the ORC:origin complex RESOLUTION OF D-LOOP STRUCTURES%REACTOME%R-RNO-5693537.1 Resolution of D-Loop Structures SPHINGOLIPID DE NOVO BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 66%10145630 Sphingolipid de novo biosynthesis CLEARANCE OF DOPAMINE%REACTOME%R-RNO-379401.1 Clearance of dopamine GABA SYNTHESIS%REACTOME DATABASE ID RELEASE 66%10145746 GABA synthesis SUMOYLATION OF TRANSCRIPTION COFACTORS%REACTOME DATABASE ID RELEASE 66%10145995 SUMOylation of transcription cofactors SIGNALING BY WNT%REACTOME DATABASE ID RELEASE 66%10145342 Signaling by WNT ESTROGEN BIOSYNTHESIS%REACTOME%R-RNO-193144.1 Estrogen biosynthesis SUMOYLATION OF CHROMATIN ORGANIZATION PROTEINS%REACTOME%R-RNO-4551638.1 SUMOylation of chromatin organization proteins CLEAVAGE OF THE DAMAGED PURINE%REACTOME DATABASE ID RELEASE 66%10144974 Cleavage of the damaged purine DEPOLYMERISATION OF THE NUCLEAR LAMINA%REACTOME DATABASE ID RELEASE 66%10146031 Depolymerisation of the Nuclear Lamina EPIGENETIC REGULATION OF GENE EXPRESSION%REACTOME DATABASE ID RELEASE 66%10145445 Epigenetic regulation of gene expression REACTIONS SPECIFIC TO THE HYBRID N-GLYCAN SYNTHESIS PATHWAY%REACTOME%R-RNO-975574.1 Reactions specific to the hybrid N-glycan synthesis pathway RHO GTPASES ACTIVATE PAKS%REACTOME%R-RNO-5627123.1 RHO GTPases activate PAKs DEGRADATION OF DVL%REACTOME DATABASE ID RELEASE 66%10145877 Degradation of DVL TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS%REACTOME DATABASE ID RELEASE 66%10145193 TGF-beta receptor signaling activates SMADs PYRUVATE METABOLISM%REACTOME%R-RNO-70268.1 Pyruvate metabolism PLATELET ACTIVATION, SIGNALING AND AGGREGATION%REACTOME DATABASE ID RELEASE 66%10145027 Platelet activation, signaling and aggregation LOSS OF NLP FROM MITOTIC CENTROSOMES%REACTOME%R-RNO-380259.1 Loss of Nlp from mitotic centrosomes CAM PATHWAY%REACTOME DATABASE ID RELEASE 66%10144992 CaM pathway SIGNALING BY SCF-KIT%REACTOME DATABASE ID RELEASE 66%10145420 Signaling by SCF-KIT TIGHT JUNCTION INTERACTIONS%REACTOME%R-RNO-420029.1 Tight junction interactions NUCLEOTIDE METABOLISM%REACTOME DATABASE ID RELEASE 66%10144816 Nucleotide metabolism INHIBITION OF ADENYLATE CYCLASE PATHWAY%REACTOME%R-RNO-997269.1 Inhibition of adenylate cyclase pathway RNA POLYMERASE II TRANSCRIBES SNRNA GENES%REACTOME DATABASE ID RELEASE 66%10146187 RNA polymerase II transcribes snRNA genes MRNA DECAY BY 3' TO 5' EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 66%10145639 mRNA decay by 3' to 5' exoribonuclease AMINE-DERIVED HORMONES%REACTOME%R-RNO-209776.1 Amine-derived hormones PROGRESSIVE TRIMMING OF ALPHA-1,2-LINKED MANNOSE RESIDUES FROM MAN9 8 7GLCNAC2 TO PRODUCE MAN5GLCNAC2%REACTOME%R-RNO-964827.1 Progressive trimming of alpha-1,2-linked mannose residues from Man9 8 7GlcNAc2 to produce Man5GlcNAc2 AMINO ACID AND DERIVATIVE METABOLISM%REACTOME%R-RNO-71291.1 Amino acid and derivative metabolism INOSITOL PHOSPHATE METABOLISM%REACTOME%R-RNO-1483249.1 Inositol phosphate metabolism FORMATION OF ATP BY CHEMIOSMOTIC COUPLING%REACTOME DATABASE ID RELEASE 66%10145126 Formation of ATP by chemiosmotic coupling ACTIVATION OF SMO%REACTOME DATABASE ID RELEASE 66%10146091 Activation of SMO GLI3 IS PROCESSED TO GLI3R BY THE PROTEASOME%REACTOME DATABASE ID RELEASE 66%10146075 GLI3 is processed to GLI3R by the proteasome RELEASE OF HH-NP FROM THE SECRETING CELL%REACTOME DATABASE ID RELEASE 66%10146062 Release of Hh-Np from the secreting cell ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES%REACTOME%R-RNO-2022090.1 Assembly of collagen fibrils and other multimeric structures PEROXISOMAL PROTEIN IMPORT%REACTOME DATABASE ID RELEASE 66%10146282 Peroxisomal protein import RECYCLING PATHWAY OF L1%REACTOME DATABASE ID RELEASE 66%10145501 Recycling pathway of L1 VASOPRESSIN REGULATES RENAL WATER HOMEOSTASIS VIA AQUAPORINS%REACTOME%R-RNO-432040.1 Vasopressin regulates renal water homeostasis via Aquaporins PI5P REGULATES TP53 ACETYLATION%REACTOME%R-RNO-6811555.1 PI5P Regulates TP53 Acetylation HYPUSINYLATION%REACTOME%R-RNO-204626.1 Hypusinylation UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1%REACTOME DATABASE ID RELEASE 66%10144899 Ubiquitin-dependent degradation of Cyclin D1 VEGFA-VEGFR2 PATHWAY%REACTOME DATABASE ID RELEASE 66%10145272 VEGFA-VEGFR2 Pathway TRANSCRIPTIONAL REGULATION BY RUNX3%REACTOME%R-RNO-8878159.1 Transcriptional regulation by RUNX3 TP53 REGULATES TRANSCRIPTION OF DNA REPAIR GENES%REACTOME DATABASE ID RELEASE 66%10146165 TP53 Regulates Transcription of DNA Repair Genes PI-3K CASCADE:FGFR2%REACTOME DATABASE ID RELEASE 66%10145254 PI-3K cascade:FGFR2 TRANSLESION SYNTHESIS BY REV1%REACTOME DATABASE ID RELEASE 66%10144976 Translesion synthesis by REV1 SHC1 EVENTS IN ERBB4 SIGNALING%REACTOME DATABASE ID RELEASE 66%10145825 SHC1 events in ERBB4 signaling TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM%REACTOME DATABASE ID RELEASE 66%10144896 Transport of Mature Transcript to Cytoplasm CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 66%10144717 CDT1 association with the CDC6:ORC:origin complex ACTIVATION OF BMF AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%R-RNO-139910.1 Activation of BMF and translocation to mitochondria CELL CYCLE, MITOTIC%REACTOME DATABASE ID RELEASE 66%10144721 Cell Cycle, Mitotic NEGATIVE REGULATION OF MET ACTIVITY%REACTOME%R-RNO-6807004.1 Negative regulation of MET activity MTOR SIGNALLING%REACTOME DATABASE ID RELEASE 66%10145128 mTOR signalling PURINE CATABOLISM%REACTOME%R-RNO-74259.1 Purine catabolism PHENYLALANINE AND TYROSINE CATABOLISM%REACTOME%R-RNO-71182.1 Phenylalanine and tyrosine catabolism SYNTHESIS OF DIPHTHAMIDE-EEF2%REACTOME DATABASE ID RELEASE 66%10146058 Synthesis of diphthamide-EEF2 TRIGLYCERIDE CATABOLISM%REACTOME%R-RNO-163560.1 Triglyceride catabolism CD28 CO-STIMULATION%REACTOME DATABASE ID RELEASE 66%10145354 CD28 co-stimulation REMOVAL OF AMINOTERMINAL PROPEPTIDES FROM GAMMA-CARBOXYLATED PROTEINS%REACTOME%R-RNO-159782.1 Removal of aminoterminal propeptides from gamma-carboxylated proteins EGFR TRANSACTIVATION BY GASTRIN%REACTOME%R-RNO-2179392.1 EGFR Transactivation by Gastrin GENE SILENCING BY RNA%REACTOME DATABASE ID RELEASE 66%10145435 Gene Silencing by RNA RUNX1 REGULATES GENES INVOLVED IN MEGAKARYOCYTE DIFFERENTIATION AND PLATELET FUNCTION%REACTOME%R-RNO-8936459.1 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function ONCOGENE INDUCED SENESCENCE%REACTOME DATABASE ID RELEASE 66%10145265 Oncogene Induced Senescence BIOSYNTHESIS OF MARESIN CONJUGATES IN TISSUE REGENERATION (MCTR)%REACTOME DATABASE ID RELEASE 66%10146313 Biosynthesis of maresin conjugates in tissue regeneration (MCTR) ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS%REACTOME DATABASE ID RELEASE 66%10145721 Acetylcholine binding and downstream events LIPID PARTICLE ORGANIZATION%REACTOME%R-RNO-8964572.1 Lipid particle organization TYPE I HEMIDESMOSOME ASSEMBLY%REACTOME DATABASE ID RELEASE 66%10145647 Type I hemidesmosome assembly METABOLISM OF INGESTED MESEO2H INTO MESEH%REACTOME%R-RNO-5263617.1 Metabolism of ingested MeSeO2H into MeSeH PROTEIN METHYLATION%REACTOME%R-RNO-8876725.1 Protein methylation SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE%REACTOME DATABASE ID RELEASE 66%10145901 Synthesis of PIPs at the Golgi membrane LAMININ INTERACTIONS%REACTOME DATABASE ID RELEASE 66%10145448 Laminin interactions SMAC BINDS TO IAPS%REACTOME%R-RNO-111463.1 SMAC binds to IAPs NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING%REACTOME%R-RNO-936440.1 Negative regulators of RIG-I MDA5 signaling HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM%REACTOME DATABASE ID RELEASE 66%10145731 Heparan sulfate heparin (HS-GAG) metabolism APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS%REACTOME DATABASE ID RELEASE 66%10145386 Apoptotic cleavage of cell adhesion proteins ASPARAGINE N-LINKED GLYCOSYLATION%REACTOME%R-RNO-446203.1 Asparagine N-linked glycosylation FORMATION OF FIBRIN CLOT (CLOTTING CASCADE)%REACTOME%R-RNO-140877.1 Formation of Fibrin Clot (Clotting Cascade) CD28 DEPENDENT PI3K AKT SIGNALING%REACTOME%R-RNO-389357.1 CD28 dependent PI3K Akt signaling TYSND1 CLEAVES PEROXISOMAL PROTEINS%REACTOME DATABASE ID RELEASE 66%10146324 TYSND1 cleaves peroxisomal proteins INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX%REACTOME%R-RNO-141430.1 Inactivation of APC C via direct inhibition of the APC C complex GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION%REACTOME%R-RNO-162658.1 Golgi Cisternae Pericentriolar Stack Reorganization LYSOSOME VESICLE BIOGENESIS%REACTOME%R-RNO-432720.1 Lysosome Vesicle Biogenesis PD-1 SIGNALING%REACTOME%R-RNO-389948.1 PD-1 signaling TRANSPORT OF BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS%REACTOME%R-RNO-425366.1 Transport of bile salts and organic acids, metal ions and amine compounds SIGNALLING TO RAS%REACTOME DATABASE ID RELEASE 66%10145202 Signalling to RAS ACTIVATION OF NF-KAPPAB IN B CELLS%REACTOME%R-RNO-1169091.1 Activation of NF-kappaB in B cells NUCLEOSOME ASSEMBLY%REACTOME%R-RNO-774815.1 Nucleosome assembly DDX58 IFIH1-MEDIATED INDUCTION OF INTERFERON-ALPHA BETA%REACTOME%R-RNO-168928.1 DDX58 IFIH1-mediated induction of interferon-alpha beta EGFR DOWNREGULATION%REACTOME DATABASE ID RELEASE 66%10145266 EGFR downregulation INTERLEUKIN-1 FAMILY SIGNALING%REACTOME DATABASE ID RELEASE 66%10145170 Interleukin-1 family signaling SUMOYLATION OF INTRACELLULAR RECEPTORS%REACTOME%R-RNO-4090294.1 SUMOylation of intracellular receptors RUNX3 REGULATES P14-ARF%REACTOME DATABASE ID RELEASE 66%10146279 RUNX3 regulates p14-ARF ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS%REACTOME DATABASE ID RELEASE 66%10145174 ZBP1(DAI) mediated induction of type I IFNs PROTON OLIGOPEPTIDE COTRANSPORTERS%REACTOME DATABASE ID RELEASE 66%10145629 Proton oligopeptide cotransporters METALLOPROTEASE DUBS%REACTOME DATABASE ID RELEASE 66%10146145 Metalloprotease DUBs ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION%REACTOME%R-RNO-450302.1 activated TAK1 mediates p38 MAPK activation NEGATIVE FEEDBACK REGULATION OF MAPK PATHWAY%REACTOME%R-RNO-5674499.1 Negative feedback regulation of MAPK pathway ALPHA-OXIDATION OF PHYTANATE%REACTOME DATABASE ID RELEASE 66%10145549 Alpha-oxidation of phytanate LIGAND-DEPENDENT CASPASE ACTIVATION%REACTOME DATABASE ID RELEASE 66%10144860 Ligand-dependent caspase activation PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE%REACTOME DATABASE ID RELEASE 66%10144782 Pyruvate metabolism and Citric Acid (TCA) cycle CD28 DEPENDENT VAV1 PATHWAY%REACTOME DATABASE ID RELEASE 66%10145542 CD28 dependent Vav1 pathway AMINE LIGAND-BINDING RECEPTORS%REACTOME%R-RNO-375280.1 Amine ligand-binding receptors MRNA DECAY BY 5' TO 3' EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 66%10145636 mRNA decay by 5' to 3' exoribonuclease MOLYBDENUM COFACTOR BIOSYNTHESIS%REACTOME%R-RNO-947581.1 Molybdenum cofactor biosynthesis TRANSLESION SYNTHESIS BY Y FAMILY DNA POLYMERASES BYPASSES LESIONS ON DNA TEMPLATE%REACTOME DATABASE ID RELEASE 66%10144977 Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template HISTIDINE, LYSINE, PHENYLALANINE, TYROSINE, PROLINE AND TRYPTOPHAN CATABOLISM%REACTOME DATABASE ID RELEASE 66%10144795 Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism SPERM MOTILITY AND TAXES%REACTOME%R-RNO-1300642.1 Sperm Motility And Taxes ENZYMATIC DEGRADATION OF DOPAMINE BY COMT%REACTOME DATABASE ID RELEASE 66%10145520 Enzymatic degradation of dopamine by COMT REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE%REACTOME%R-RNO-176408.1 Regulation of APC C activators between G1 S and early anaphase RNA POLYMERASE III TRANSCRIPTION%REACTOME%R-RNO-74158.1 RNA Polymerase III Transcription ACTIVATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME DATABASE ID RELEASE 66%10144871 Activation of the phototransduction cascade FERTILIZATION%REACTOME%R-RNO-1187000.1 Fertilization SIGNAL AMPLIFICATION%REACTOME%R-RNO-392518.1 Signal amplification ACTIVATED PKN1 STIMULATES TRANSCRIPTION OF AR (ANDROGEN RECEPTOR) REGULATED GENES KLK2 AND KLK3%REACTOME DATABASE ID RELEASE 66%10146086 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE%REACTOME%R-RNO-174414.1 Processive synthesis on the C-strand of the telomere IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 66%10145133 Immune System PORPHYRIN METABOLISM%REACTOME DATABASE ID RELEASE 66%10145085 Porphyrin metabolism RA BIOSYNTHESIS PATHWAY%REACTOME%R-RNO-5365859.1 RA biosynthesis pathway CLASSICAL KIR CHANNELS%REACTOME DATABASE ID RELEASE 66%10145835 Classical Kir channels REGULATION BY C-FLIP%REACTOME DATABASE ID RELEASE 66%10146009 Regulation by c-FLIP PROTEIN UBIQUITINATION%REACTOME DATABASE ID RELEASE 66%10146215 Protein ubiquitination THROMBOXANE SIGNALLING THROUGH TP RECEPTOR%REACTOME%R-RNO-428930.1 Thromboxane signalling through TP receptor APC C:CDC20 MEDIATED DEGRADATION OF SECURIN%REACTOME%R-RNO-174154.1 APC C:Cdc20 mediated degradation of Securin SHC1 EVENTS IN EGFR SIGNALING%REACTOME%R-RNO-180336.1 SHC1 events in EGFR signaling CHYLOMICRON REMODELING%REACTOME DATABASE ID RELEASE 66%10145241 Chylomicron remodeling PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA%REACTOME%R-RNO-72203.1 Processing of Capped Intron-Containing Pre-mRNA INSULIN RECEPTOR RECYCLING%REACTOME%R-RNO-77387.1 Insulin receptor recycling INTERLEUKIN-6 SIGNALING%REACTOME DATABASE ID RELEASE 66%10145796 Interleukin-6 signaling ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%R-RNO-111447.1 Activation of BAD and translocation to mitochondria C-SRC MEDIATED REGULATION OF CX43 FUNCTION AND CLOSURE OF GAP JUNCTIONS%REACTOME%R-RNO-191647.1 c-src mediated regulation of Cx43 function and closure of gap junctions EUKARYOTIC TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 66%10144835 Eukaryotic Translation Initiation TIE2 SIGNALING%REACTOME%R-RNO-210993.1 Tie2 Signaling SMALL INTERFERING RNA (SIRNA) BIOGENESIS%REACTOME%R-RNO-426486.1 Small interfering RNA (siRNA) biogenesis ARACHIDONATE PRODUCTION FROM DAG%REACTOME%R-RNO-426048.1 Arachidonate production from DAG NUCLEOTIDE EXCISION REPAIR%REACTOME%R-RNO-5696398.1 Nucleotide Excision Repair CAP-DEPENDENT TRANSLATION INITIATION%REACTOME%R-RNO-72737.1 Cap-dependent Translation Initiation TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE%REACTOME%R-RNO-168188.1 Toll Like Receptor TLR6:TLR2 Cascade CARBOHYDRATE METABOLISM%REACTOME DATABASE ID RELEASE 66%10144766 Carbohydrate metabolism ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS%REACTOME%R-RNO-176187.1 Activation of ATR in response to replication stress EXTRACELLULAR MATRIX ORGANIZATION%REACTOME DATABASE ID RELEASE 66%10145031 Extracellular matrix organization LEADING STRAND SYNTHESIS%REACTOME%R-RNO-69109.1 Leading Strand Synthesis REGULATED PROTEOLYSIS OF P75NTR%REACTOME DATABASE ID RELEASE 66%10145335 Regulated proteolysis of p75NTR MISMATCH REPAIR (MMR) DIRECTED BY MSH2:MSH3 (MUTSBETA)%REACTOME%R-RNO-5358606.1 Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) NEUTROPHIL DEGRANULATION%REACTOME%R-RNO-6798695.1 Neutrophil degranulation REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA%REACTOME DATABASE ID RELEASE 66%10145918 Regulation of innate immune responses to cytosolic DNA RHO GTPASES ACTIVATE CIT%REACTOME DATABASE ID RELEASE 66%10146123 RHO GTPases activate CIT FORMATION OF INCISION COMPLEX IN GG-NER%REACTOME%R-RNO-5696395.1 Formation of Incision Complex in GG-NER NTF3 ACTIVATES NTRK3 SIGNALING%REACTOME%R-RNO-9034013.1 NTF3 activates NTRK3 signaling REMOVAL OF THE FLAP INTERMEDIATE%REACTOME DATABASE ID RELEASE 66%10144734 Removal of the Flap Intermediate THE PROTON BUFFERING MODEL%REACTOME%R-RNO-167827.1 The proton buffering model POTASSIUM TRANSPORT CHANNELS%REACTOME%R-RNO-1296067.1 Potassium transport channels RUNX2 REGULATES OSTEOBLAST DIFFERENTIATION%REACTOME%R-RNO-8940973.1 RUNX2 regulates osteoblast differentiation BUTYRATE RESPONSE FACTOR 1 (BRF1) BINDS AND DESTABILIZES MRNA%REACTOME%R-RNO-450385.1 Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA NEUROTRANSMITTER CLEARANCE%REACTOME%R-RNO-112311.1 Neurotransmitter clearance RUNX3 REGULATES YAP1-MEDIATED TRANSCRIPTION%REACTOME DATABASE ID RELEASE 66%10146278 RUNX3 regulates YAP1-mediated transcription ESTABLISHMENT OF SISTER CHROMATID COHESION%REACTOME DATABASE ID RELEASE 66%10145970 Establishment of Sister Chromatid Cohesion PRC2 METHYLATES HISTONES AND DNA%REACTOME%R-RNO-212300.1 PRC2 methylates histones and DNA FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION%REACTOME%R-RNO-434316.1 Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION%REACTOME%R-RNO-381340.1 Transcriptional regulation of white adipocyte differentiation INTERLEUKIN-20 FAMILY SIGNALING%REACTOME%R-RNO-8854691.1 Interleukin-20 family signaling RHO GTPASE EFFECTORS%REACTOME DATABASE ID RELEASE 66%10144888 RHO GTPase Effectors HDL CLEARANCE%REACTOME%R-RNO-8964011.1 HDL clearance BIOSYNTHESIS OF DHA-DERIVED SPMS%REACTOME DATABASE ID RELEASE 66%10146302 Biosynthesis of DHA-derived SPMs IRS-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%R-RNO-2428928.1 IRS-related events triggered by IGF1R INSULIN RECEPTOR SIGNALLING CASCADE%REACTOME DATABASE ID RELEASE 66%10144875 Insulin receptor signalling cascade P2Y RECEPTORS%REACTOME%R-RNO-417957.1 P2Y receptors REGULATION OF ORNITHINE DECARBOXYLASE (ODC)%REACTOME DATABASE ID RELEASE 66%10145465 Regulation of ornithine decarboxylase (ODC) TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS%REACTOME%R-RNO-174417.1 Telomere C-strand (Lagging Strand) Synthesis PROTON-COUPLED MONOCARBOXYLATE TRANSPORT%REACTOME DATABASE ID RELEASE 66%10145649 Proton-coupled monocarboxylate transport INSULIN EFFECTS INCREASED SYNTHESIS OF XYLULOSE-5-PHOSPHATE%REACTOME%R-RNO-163754.1 Insulin effects increased synthesis of Xylulose-5-Phosphate TRANSPORT OF NUCLEOSIDES AND FREE PURINE AND PYRIMIDINE BASES ACROSS THE PLASMA MEMBRANE%REACTOME%R-RNO-83936.1 Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane METHYLATION%REACTOME DATABASE ID RELEASE 66%10144922 Methylation GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION%REACTOME%R-RNO-381676.1 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion CHYLOMICRON ASSEMBLY%REACTOME DATABASE ID RELEASE 66%10145238 Chylomicron assembly MYD88-INDEPENDENT TLR4 CASCADE%REACTOME%R-RNO-166166.1 MyD88-independent TLR4 cascade HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145724 Highly calcium permeable postsynaptic nicotinic acetylcholine receptors G ALPHA (12 13) SIGNALLING EVENTS%REACTOME%R-RNO-416482.1 G alpha (12 13) signalling events EPHRIN SIGNALING%REACTOME%R-RNO-3928664.1 Ephrin signaling METABOLISM OF NITRIC OXIDE%REACTOME DATABASE ID RELEASE 66%10145396 Metabolism of nitric oxide SUMOYLATION OF UBIQUITINYLATION PROTEINS%REACTOME%R-RNO-3232142.1 SUMOylation of ubiquitinylation proteins SIGNALING BY TGF-BETA RECEPTOR COMPLEX%REACTOME%R-RNO-170834.1 Signaling by TGF-beta Receptor Complex SIGNALING BY HEDGEHOG%REACTOME%R-RNO-5358351.1 Signaling by Hedgehog GABA A (RHO) RECEPTOR ACTIVATION%REACTOME DATABASE ID RELEASE 66%10145776 GABA A (rho) receptor activation SYNTHESIS OF PIPS IN THE NUCLEUS%REACTOME%R-RNO-8847453.1 Synthesis of PIPs in the nucleus TP53 REGULATES METABOLIC GENES%REACTOME DATABASE ID RELEASE 66%10144779 TP53 Regulates Metabolic Genes VLDL ASSEMBLY%REACTOME%R-RNO-8866423.1 VLDL assembly GLYCOSPHINGOLIPID METABOLISM%REACTOME%R-RNO-1660662.1 Glycosphingolipid metabolism PCP CE PATHWAY%REACTOME%R-RNO-4086400.1 PCP CE pathway OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA%REACTOME%R-RNO-1234176.1 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha OREXIN AND NEUROPEPTIDES FF AND QRFP BIND TO THEIR RESPECTIVE RECEPTORS%REACTOME%R-RNO-389397.1 Orexin and neuropeptides FF and QRFP bind to their respective receptors REGULATION OF TP53 EXPRESSION AND DEGRADATION%REACTOME%R-RNO-6806003.1 Regulation of TP53 Expression and Degradation METABOLISM OF SEROTONIN%REACTOME%R-RNO-380612.1 Metabolism of serotonin ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION%REACTOME DATABASE ID RELEASE 66%10145589 Adrenaline,noradrenaline inhibits insulin secretion DECTIN-1 MEDIATED NONCANONICAL NF-KB SIGNALING%REACTOME%R-RNO-5607761.1 Dectin-1 mediated noncanonical NF-kB signaling NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME DATABASE ID RELEASE 66%10145920 NOTCH2 Activation and Transmission of Signal to the Nucleus ESTROGEN-DEPENDENT GENE EXPRESSION%REACTOME%R-RNO-9018519.1 Estrogen-dependent gene expression TRIGLYCERIDE METABOLISM%REACTOME%R-RNO-8979227.1 Triglyceride metabolism P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME%R-RNO-372708.1 p130Cas linkage to MAPK signaling for integrins PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145719 Presynaptic nicotinic acetylcholine receptors PRE-MRNA SPLICING%REACTOME DATABASE ID RELEASE 66%10144828 pre-mRNA splicing BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS%REACTOME DATABASE ID RELEASE 66%10145554 Beta-oxidation of very long chain fatty acids PKMTS METHYLATE HISTONE LYSINES%REACTOME DATABASE ID RELEASE 66%10146041 PKMTs methylate histone lysines CHROMATIN MODIFYING ENZYMES%REACTOME%R-RNO-3247509.1 Chromatin modifying enzymes LGI-ADAM INTERACTIONS%REACTOME%R-RNO-5682910.1 LGI-ADAM interactions TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION%REACTOME DATABASE ID RELEASE 66%10145151 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7 8 or 9 activation METHIONINE SALVAGE PATHWAY%REACTOME DATABASE ID RELEASE 66%10145821 Methionine salvage pathway METABOLISM OF LIPIDS%REACTOME%R-RNO-556833.1 Metabolism of lipids INWARDLY RECTIFYING K+ CHANNELS%REACTOME DATABASE ID RELEASE 66%10145793 Inwardly rectifying K+ channels TFAP2 (AP-2) FAMILY REGULATES TRANSCRIPTION OF GROWTH FACTORS AND THEIR RECEPTORS%REACTOME%R-RNO-8866910.1 TFAP2 (AP-2) family regulates transcription of growth factors and their receptors SIGNALING BY ROBO RECEPTORS%REACTOME%R-RNO-376176.1 Signaling by ROBO receptors ORGANIC ANION TRANSPORTERS%REACTOME DATABASE ID RELEASE 66%10145484 Organic anion transporters AXONAL GROWTH INHIBITION (RHOA ACTIVATION)%REACTOME%R-RNO-193634.1 Axonal growth inhibition (RHOA activation) DOWNREGULATION OF ERBB2 SIGNALING%REACTOME%R-RNO-8863795.1 Downregulation of ERBB2 signaling ROS, RNS PRODUCTION IN PHAGOCYTES%REACTOME DATABASE ID RELEASE 66%10145602 ROS, RNS production in phagocytes GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME%R-RNO-354194.1 GRB2:SOS provides linkage to MAPK signaling for Integrins AMPLIFICATION OF SIGNAL FROM UNATTACHED KINETOCHORES VIA A MAD2 INHIBITORY SIGNAL%REACTOME DATABASE ID RELEASE 66%10145062 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal GDP-FUCOSE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 66%10145727 GDP-fucose biosynthesis REGULATION OF SIGNALING BY CBL%REACTOME%R-RNO-912631.1 Regulation of signaling by CBL CALNEXIN CALRETICULIN CYCLE%REACTOME DATABASE ID RELEASE 66%10145711 Calnexin calreticulin cycle COLLAGEN CHAIN TRIMERIZATION%REACTOME DATABASE ID RELEASE 66%10145922 Collagen chain trimerization SHC-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%R-RNO-2428933.1 SHC-related events triggered by IGF1R RAS ACTIVATION UPON CA2+ INFLUX THROUGH NMDA RECEPTOR%REACTOME%R-RNO-442982.1 Ras activation upon Ca2+ influx through NMDA receptor FRS-MEDIATED FGFR1 SIGNALING%REACTOME DATABASE ID RELEASE 66%10146102 FRS-mediated FGFR1 signaling MASTL FACILITATES MITOTIC PROGRESSION%REACTOME%R-RNO-2465910.1 MASTL Facilitates Mitotic Progression SYNTHESIS OF PE%REACTOME%R-RNO-1483213.1 Synthesis of PE INOSITOL TRANSPORTERS%REACTOME DATABASE ID RELEASE 66%10145635 Inositol transporters PHOSPHOLIPID METABOLISM%REACTOME%R-RNO-1483257.1 Phospholipid metabolism BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN%REACTOME%R-RNO-446193.1 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein BBSOME-MEDIATED CARGO-TARGETING TO CILIUM%REACTOME DATABASE ID RELEASE 66%10146078 BBSome-mediated cargo-targeting to cilium ACYL CHAIN REMODELLING OF PE%REACTOME%R-RNO-1482839.1 Acyl chain remodelling of PE RESOLUTION OF ABASIC SITES (AP SITES)%REACTOME%R-RNO-73933.1 Resolution of Abasic Sites (AP sites) ACTIVATION OF AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145580 Activation of AMPA receptors ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS%REACTOME%R-RNO-2122948.1 Activated NOTCH1 Transmits Signal to the Nucleus SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX)%REACTOME DATABASE ID RELEASE 66%10145441 Synthesis of Leukotrienes (LT) and Eoxins (EX) METABOLISM OF VITAMIN K%REACTOME%R-RNO-6806664.1 Metabolism of vitamin K OVARIAN TUMOR DOMAIN PROTEASES%REACTOME%R-RNO-5689896.1 Ovarian tumor domain proteases TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G2 CELL CYCLE ARREST%REACTOME DATABASE ID RELEASE 66%10146160 TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest EPHB-MEDIATED FORWARD SIGNALING%REACTOME DATABASE ID RELEASE 66%10146024 EPHB-mediated forward signaling APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS%REACTOME DATABASE ID RELEASE 66%10145068 APC C-mediated degradation of cell cycle proteins THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT%REACTOME DATABASE ID RELEASE 66%10144783 The citric acid (TCA) cycle and respiratory electron transport BIOTIN TRANSPORT AND METABOLISM%REACTOME DATABASE ID RELEASE 66%10145370 Biotin transport and metabolism SHC-MEDIATED CASCADE:FGFR1%REACTOME DATABASE ID RELEASE 66%10146109 SHC-mediated cascade:FGFR1 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE%REACTOME%R-RNO-77075.1 RNA Pol II CTD phosphorylation and interaction with CE AMINO ACID CONJUGATION%REACTOME DATABASE ID RELEASE 66%10145091 Amino Acid conjugation ALPHA-LINOLENIC ACID (ALA) METABOLISM%REACTOME%R-RNO-2046106.1 alpha-linolenic acid (ALA) metabolism THE PHOTOTRANSDUCTION CASCADE%REACTOME DATABASE ID RELEASE 66%10144866 The phototransduction cascade MITOCHONDRIAL FATTY ACID BETA-OXIDATION%REACTOME%R-RNO-77289.1 Mitochondrial Fatty Acid Beta-Oxidation SULFUR AMINO ACID METABOLISM%REACTOME%R-RNO-1614635.1 Sulfur amino acid metabolism NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 66%10145481 Norepinephrine Neurotransmitter Release Cycle BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145954 Binding and Uptake of Ligands by Scavenger Receptors FCERI MEDIATED CA+2 MOBILIZATION%REACTOME%R-RNO-2871809.1 FCERI mediated Ca+2 mobilization BIOSYNTHESIS OF ELECTROPHILIC Ω-3 PUFA OXO-DERIVATIVES%REACTOME DATABASE ID RELEASE 66%10146319 Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives PTEN REGULATION%REACTOME%R-RNO-6807070.1 PTEN Regulation TFAP2A ACTS AS A TRANSCRIPTIONAL REPRESSOR DURING RETINOIC ACID INDUCED CELL DIFFERENTIATION%REACTOME%R-RNO-8869496.1 TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1)%REACTOME DATABASE ID RELEASE 66%10145538 Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) TOLL LIKE RECEPTOR 4 (TLR4) CASCADE%REACTOME DATABASE ID RELEASE 66%10145130 Toll Like Receptor 4 (TLR4) Cascade ADENYLATE CYCLASE ACTIVATING PATHWAY%REACTOME DATABASE ID RELEASE 66%10145191 Adenylate cyclase activating pathway SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL%REACTOME DATABASE ID RELEASE 66%10145908 Synthesis of pyrophosphates in the cytosol NEGATIVE REGULATION OF ACTIVITY OF TFAP2 (AP-2) FAMILY TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 66%10146003 Negative regulation of activity of TFAP2 (AP-2) family transcription factors VLDL CLEARANCE%REACTOME DATABASE ID RELEASE 66%10146224 VLDL clearance RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF HSCS%REACTOME DATABASE ID RELEASE 66%10146239 RUNX1 regulates transcription of genes involved in differentiation of HSCs BIOSYNTHESIS OF DPAN-6 SPMS%REACTOME DATABASE ID RELEASE 66%10146307 Biosynthesis of DPAn-6 SPMs GROWTH HORMONE RECEPTOR SIGNALING%REACTOME DATABASE ID RELEASE 66%10145708 Growth hormone receptor signaling REUPTAKE OF GABA%REACTOME%R-RNO-888593.1 Reuptake of GABA THYROXINE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 66%10145424 Thyroxine biosynthesis PLATELET ADHESION TO EXPOSED COLLAGEN%REACTOME%R-RNO-75892.1 Platelet Adhesion to exposed collagen INITIAL TRIGGERING OF COMPLEMENT%REACTOME%R-RNO-166663.1 Initial triggering of complement FORMATION OF THE CORNIFIED ENVELOPE%REACTOME%R-RNO-6809371.1 Formation of the cornified envelope SIGNALING BY MET%REACTOME%R-RNO-6806834.1 Signaling by MET RHO GTPASES ACTIVATE FORMINS%REACTOME%R-RNO-5663220.1 RHO GTPases Activate Formins CITRIC ACID CYCLE (TCA CYCLE)%REACTOME%R-RNO-71403.1 Citric acid cycle (TCA cycle) CHAPERONIN-MEDIATED PROTEIN FOLDING%REACTOME%R-RNO-390466.1 Chaperonin-mediated protein folding KINESINS%REACTOME%R-RNO-983189.1 Kinesins SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL%REACTOME DATABASE ID RELEASE 66%10145904 Synthesis of IP3 and IP4 in the cytosol CARGO RECOGNITION FOR CLATHRIN-MEDIATED ENDOCYTOSIS%REACTOME%R-RNO-8856825.1 Cargo recognition for clathrin-mediated endocytosis ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR%REACTOME DATABASE ID RELEASE 66%10145698 Activation of Ca-permeable Kainate Receptor SIGNALING BY RHO GTPASES%REACTOME DATABASE ID RELEASE 66%10144889 Signaling by Rho GTPases OLIGOMERIZATION OF CONNEXINS INTO CONNEXONS%REACTOME DATABASE ID RELEASE 66%10145304 Oligomerization of connexins into connexons CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKK%REACTOME%R-RNO-442717.1 CREB phosphorylation through the activation of CaMKK PEPTIDE CHAIN ELONGATION%REACTOME%R-RNO-156902.1 Peptide chain elongation CLASS B 2 (SECRETIN FAMILY RECEPTORS)%REACTOME%R-RNO-373080.1 Class B 2 (Secretin family receptors) ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME DATABASE ID RELEASE 66%10145219 Activation of APC C and APC C:Cdc20 mediated degradation of mitotic proteins IRE1ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 66%10145532 IRE1alpha activates chaperones RHESUS GLYCOPROTEINS MEDIATE AMMONIUM TRANSPORT.%REACTOME DATABASE ID RELEASE 66%10145662 Rhesus glycoproteins mediate ammonium transport. RNA POLYMERASE I TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 66%10144885 RNA Polymerase I Transcription Termination APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B%REACTOME%R-RNO-174048.1 APC C:Cdc20 mediated degradation of Cyclin B MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME%REACTOME%R-RNO-975155.1 MyD88 dependent cascade initiated on endosome DSCAM INTERACTIONS%REACTOME%R-RNO-376172.1 DSCAM interactions MISCELLANEOUS TRANSPORT AND BINDING EVENTS%REACTOME%R-RNO-5223345.1 Miscellaneous transport and binding events MITOCHONDRIAL TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 66%10145117 Mitochondrial transcription initiation PINK PARKIN MEDIATED MITOPHAGY%REACTOME DATABASE ID RELEASE 66%10146045 Pink Parkin Mediated Mitophagy SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R)%REACTOME%R-RNO-2404192.1 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) INTERCONVERSION OF POLYAMINES%REACTOME DATABASE ID RELEASE 66%10145061 Interconversion of polyamines NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%R-RNO-2122947.1 NOTCH1 Intracellular Domain Regulates Transcription ELECTRIC TRANSMISSION ACROSS GAP JUNCTIONS%REACTOME DATABASE ID RELEASE 66%10145507 Electric Transmission Across Gap Junctions THE NLRP3 INFLAMMASOME%REACTOME%R-RNO-844456.1 The NLRP3 inflammasome FCGR ACTIVATION%REACTOME DATABASE ID RELEASE 66%10145910 FCGR activation SLIT2:ROBO1 INCREASES RHOA ACTIVITY%REACTOME DATABASE ID RELEASE 66%10146285 SLIT2:ROBO1 increases RHOA activity TICAM1-DEPENDENT ACTIVATION OF IRF3 IRF7%REACTOME DATABASE ID RELEASE 66%10145179 TICAM1-dependent activation of IRF3 IRF7 COX REACTIONS%REACTOME DATABASE ID RELEASE 66%10145051 COX reactions SIGNALING BY VEGF%REACTOME DATABASE ID RELEASE 66%10145273 Signaling by VEGF REGULATION OF MECP2 EXPRESSION AND ACTIVITY%REACTOME%R-RNO-9022692.1 Regulation of MECP2 expression and activity ACTIVATION OF TRKA RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145141 Activation of TRKA receptors DOWNSTREAM SIGNALING OF ACTIVATED FGFR2%REACTOME DATABASE ID RELEASE 66%10145255 Downstream signaling of activated FGFR2 VASOPRESSIN-LIKE RECEPTORS%REACTOME%R-RNO-388479.1 Vasopressin-like receptors ANCHORING OF THE BASAL BODY TO THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 66%10146081 Anchoring of the basal body to the plasma membrane ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION%REACTOME%R-RNO-2730905.1 Role of LAT2 NTAL LAB on calcium mobilization NEPHRIN FAMILY INTERACTIONS%REACTOME%R-RNO-373753.1 Nephrin family interactions IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX%REACTOME%R-RNO-937042.1 IRAK2 mediated activation of TAK1 complex PYRIMIDINE SALVAGE%REACTOME DATABASE ID RELEASE 66%10144845 Pyrimidine salvage TWIK-RELATED ALKALINE PH ACTIVATED K+ CHANNEL (TALK)%REACTOME DATABASE ID RELEASE 66%10145847 TWIK-related alkaline pH activated K+ channel (TALK) THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS)%REACTOME%R-RNO-456926.1 Thrombin signalling through proteinase activated receptors (PARs) DEADENYLATION OF MRNA%REACTOME DATABASE ID RELEASE 66%10145638 Deadenylation of mRNA FORMYL PEPTIDE RECEPTORS BIND FORMYL PEPTIDES AND MANY OTHER LIGANDS%REACTOME DATABASE ID RELEASE 66%10145663 Formyl peptide receptors bind formyl peptides and many other ligands ACTIVATION AND OLIGOMERIZATION OF BAK PROTEIN%REACTOME DATABASE ID RELEASE 66%10145015 Activation and oligomerization of BAK protein A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS%REACTOME%R-RNO-1971475.1 A tetrasaccharide linker sequence is required for GAG synthesis PKA ACTIVATION IN GLUCAGON SIGNALLING%REACTOME%R-RNO-164378.1 PKA activation in glucagon signalling CLASS C 3 (METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS)%REACTOME DATABASE ID RELEASE 66%10145488 Class C 3 (Metabotropic glutamate pheromone receptors) CA-DEPENDENT EVENTS%REACTOME DATABASE ID RELEASE 66%10144989 Ca-dependent events SUMOYLATION OF RNA BINDING PROTEINS%REACTOME DATABASE ID RELEASE 66%10146034 SUMOylation of RNA binding proteins VITAMIN B5 (PANTOTHENATE) METABOLISM%REACTOME%R-RNO-199220.1 Vitamin B5 (pantothenate) metabolism ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING%REACTOME%R-RNO-451326.1 Activation of kainate receptors upon glutamate binding TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS%REACTOME DATABASE ID RELEASE 66%10145878 Transcriptional activation of mitochondrial biogenesis DOWNSTREAM SIGNALING OF ACTIVATED FGFR1%REACTOME%R-RNO-5654687.1 Downstream signaling of activated FGFR1 TRP CHANNELS%REACTOME%R-RNO-3295583.1 TRP channels SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION%REACTOME%R-RNO-2173796.1 SMAD2 SMAD3:SMAD4 heterotrimer regulates transcription DARPP-32 EVENTS%REACTOME DATABASE ID RELEASE 66%10145005 DARPP-32 events ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON%REACTOME DATABASE ID RELEASE 66%10145137 Activation of IRF3 IRF7 mediated by TBK1 IKK epsilon GLUCAGON-TYPE LIGAND RECEPTORS%REACTOME%R-RNO-420092.1 Glucagon-type ligand receptors SUMO E3 LIGASES SUMOYLATE TARGET PROTEINS%REACTOME DATABASE ID RELEASE 66%10145992 SUMO E3 ligases SUMOylate target proteins AXON GUIDANCE%REACTOME%R-RNO-422475.1 Axon guidance SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE%REACTOME%R-RNO-416572.1 Sema4D induced cell migration and growth-cone collapse FREE FATTY ACIDS REGULATE INSULIN SECRETION%REACTOME DATABASE ID RELEASE 66%10145587 Free fatty acids regulate insulin secretion SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN%REACTOME DATABASE ID RELEASE 66%10145615 Synthesis, secretion, and deacylation of Ghrelin SIGNALING BY NOTCH3%REACTOME DATABASE ID RELEASE 66%10145952 Signaling by NOTCH3 OXYGEN-DEPENDENT ASPARAGINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA%REACTOME DATABASE ID RELEASE 66%10145810 Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha REPRODUCTION%REACTOME%R-RNO-1474165.1 Reproduction PHOSPHOLIPASE C-MEDIATED CASCADE: FGFR1%REACTOME%R-RNO-5654219.1 Phospholipase C-mediated cascade: FGFR1 MELANIN BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 66%10146119 Melanin biosynthesis DIGESTION AND ABSORPTION%REACTOME%R-RNO-8963743.1 Digestion and absorption GAP JUNCTION DEGRADATION%REACTOME DATABASE ID RELEASE 66%10145296 Gap junction degradation O-LINKED GLYCOSYLATION OF MUCINS%REACTOME%R-RNO-913709.1 O-linked glycosylation of mucins CTLA4 INHIBITORY SIGNALING%REACTOME DATABASE ID RELEASE 66%10145541 CTLA4 inhibitory signaling PENTOSE PHOSPHATE PATHWAY%REACTOME%R-RNO-71336.1 Pentose phosphate pathway UBIQUINOL BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 66%10145949 Ubiquinol biosynthesis PHASE I - FUNCTIONALIZATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 66%10144820 Phase I - Functionalization of compounds PRESYNAPTIC PHASE OF HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME DATABASE ID RELEASE 66%10146131 Presynaptic phase of homologous DNA pairing and strand exchange SLC-MEDIATED TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 66%10144952 SLC-mediated transmembrane transport ASYMMETRIC LOCALIZATION OF PCP PROTEINS%REACTOME%R-RNO-4608870.1 Asymmetric localization of PCP proteins ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12%REACTOME%R-RNO-392170.1 ADP signalling through P2Y purinoceptor 12 SIGNALING BY TGF-BETA FAMILY MEMBERS%REACTOME DATABASE ID RELEASE 66%10145195 Signaling by TGF-beta family members MITOTIC G2-G2 M PHASES%REACTOME DATABASE ID RELEASE 66%10145075 Mitotic G2-G2 M phases SIGNALLING TO ERK5%REACTOME DATABASE ID RELEASE 66%10145365 Signalling to ERK5 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS.%REACTOME%R-RNO-163200.1 Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. MYD88:MAL(TIRAP) CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME%R-RNO-166058.1 MyD88:MAL(TIRAP) cascade initiated on plasma membrane FORMATION OF THE ACTIVE COFACTOR, UDP-GLUCURONATE%REACTOME DATABASE ID RELEASE 66%10144771 Formation of the active cofactor, UDP-glucuronate GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK%REACTOME DATABASE ID RELEASE 66%10145366 Gastrin-CREB signalling pathway via PKC and MAPK INTRACELLULAR OXYGEN TRANSPORT%REACTOME%R-RNO-8981607.1 Intracellular oxygen transport NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS%REACTOME DATABASE ID RELEASE 66%10145178 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways VITAMINS B6 ACTIVATION TO PYRIDOXAL PHOSPHATE%REACTOME%R-RNO-964975.1 Vitamins B6 activation to pyridoxal phosphate SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION%REACTOME DATABASE ID RELEASE 66%10145592 Sema4D mediated inhibition of cell attachment and migration WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2%REACTOME%R-RNO-5140745.1 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME%R-RNO-110381.1 Resolution of AP sites via the single-nucleotide replacement pathway SCAVENGING BY CLASS B RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145958 Scavenging by Class B Receptors REGULATION OF TLR BY ENDOGENOUS LIGAND%REACTOME DATABASE ID RELEASE 66%10146066 Regulation of TLR by endogenous ligand NOTCH-HLH TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 66%10145446 Notch-HLH transcription pathway VITAMINS%REACTOME%R-RNO-211916.1 Vitamins UCH PROTEINASES%REACTOME DATABASE ID RELEASE 66%10146120 UCH proteinases ADRENOCEPTORS%REACTOME%R-RNO-390696.1 Adrenoceptors REGULATION OF TP53 EXPRESSION%REACTOME DATABASE ID RELEASE 66%10146179 Regulation of TP53 Expression POST-TRANSLATIONAL PROTEIN MODIFICATION%REACTOME%R-RNO-597592.1 Post-translational protein modification FGFR1B LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 66%10145285 FGFR1b ligand binding and activation HOMOLOGY DIRECTED REPAIR%REACTOME DATABASE ID RELEASE 66%10144914 Homology Directed Repair TRANSCRIPTION-COUPLED NUCLEOTIDE EXCISION REPAIR (TC-NER)%REACTOME%R-RNO-6781827.1 Transcription-Coupled Nucleotide Excision Repair (TC-NER) TRANSCRIPTIONAL REGULATION BY RUNX2%REACTOME DATABASE ID RELEASE 66%10146258 Transcriptional regulation by RUNX2 PRE-NOTCH PROCESSING IN GOLGI%REACTOME%R-RNO-1912420.1 Pre-NOTCH Processing in Golgi CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA%REACTOME DATABASE ID RELEASE 66%10145175 Cytosolic sensors of pathogen-associated DNA HDL ASSEMBLY%REACTOME DATABASE ID RELEASE 66%10145449 HDL assembly ERYTHROCYTES TAKE UP OXYGEN AND RELEASE CARBON DIOXIDE%REACTOME DATABASE ID RELEASE 66%10145820 Erythrocytes take up oxygen and release carbon dioxide REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN%REACTOME%R-RNO-1234174.1 Regulation of Hypoxia-inducible Factor (HIF) by oxygen PHASE 2 - PLATEAU PHASE%REACTOME%R-RNO-5576893.1 Phase 2 - plateau phase GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER%REACTOME%R-RNO-6782210.1 Gap-filling DNA repair synthesis and ligation in TC-NER RHO GTPASE CYCLE%REACTOME DATABASE ID RELEASE 66%10145340 Rho GTPase cycle GLUTATHIONE CONJUGATION%REACTOME%R-RNO-156590.1 Glutathione conjugation PTK6 DOWN-REGULATION%REACTOME DATABASE ID RELEASE 66%10146208 PTK6 Down-Regulation TP53 REGULATES TRANSCRIPTION OF SEVERAL ADDITIONAL CELL DEATH GENES WHOSE SPECIFIC ROLES IN P53-DEPENDENT APOPTOSIS REMAIN UNCERTAIN%REACTOME DATABASE ID RELEASE 66%10146175 TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain CYCLIN A B1 B2 ASSOCIATED EVENTS DURING G2 M TRANSITION%REACTOME%R-RNO-69273.1 Cyclin A B1 B2 associated events during G2 M transition SPHINGOLIPID METABOLISM%REACTOME%R-RNO-428157.1 Sphingolipid metabolism SPERM:OOCYTE MEMBRANE BINDING%REACTOME DATABASE ID RELEASE 66%10145840 Sperm:Oocyte Membrane Binding CRISTAE FORMATION%REACTOME%R-RNO-8949613.1 Cristae formation AROMATIC AMINES CAN BE N-HYDROXYLATED OR N-DEALKYLATED BY CYP1A2%REACTOME%R-RNO-211957.1 Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 ABACAVIR TRANSPORT AND METABOLISM%REACTOME DATABASE ID RELEASE 66%10145942 Abacavir transport and metabolism REGULATION OF CYTOSKELETAL REMODELING AND CELL SPREADING BY IPP COMPLEX COMPONENTS%REACTOME DATABASE ID RELEASE 66%10145641 Regulation of cytoskeletal remodeling and cell spreading by IPP complex components PHOSPHOLIPASE C-MEDIATED CASCADE; FGFR3%REACTOME DATABASE ID RELEASE 66%10146099 Phospholipase C-mediated cascade; FGFR3 RAF MAP KINASE CASCADE%REACTOME%R-RNO-5673001.1 RAF MAP kinase cascade ABASIC SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 66%10144981 Abasic sugar-phosphate removal via the single-nucleotide replacement pathway CRMPS IN SEMA3A SIGNALING%REACTOME%R-RNO-399956.1 CRMPs in Sema3A signaling REGULATION OF TP53 ACTIVITY THROUGH ACETYLATION%REACTOME DATABASE ID RELEASE 66%10146001 Regulation of TP53 Activity through Acetylation BIOSYNTHESIS OF MARESINS%REACTOME%R-RNO-9018682.1 Biosynthesis of maresins TP53 REGULATES TRANSCRIPTION OF CELL CYCLE GENES%REACTOME%R-RNO-6791312.1 TP53 Regulates Transcription of Cell Cycle Genes PLC BETA MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 66%10144985 PLC beta mediated events REGULATION OF EXPRESSION OF SLITS AND ROBOS%REACTOME DATABASE ID RELEASE 66%10146286 Regulation of expression of SLITs and ROBOs GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION%REACTOME DATABASE ID RELEASE 66%10145475 GABA synthesis, release, reuptake and degradation INTEGRIN ALPHAIIB BETA3 SIGNALING%REACTOME DATABASE ID RELEASE 66%10145476 Integrin alphaIIb beta3 signaling FCERI MEDIATED MAPK ACTIVATION%REACTOME DATABASE ID RELEASE 66%10145166 FCERI mediated MAPK activation PTK6 ACTIVATES STAT3%REACTOME DATABASE ID RELEASE 66%10146200 PTK6 Activates STAT3 CLEC7A INFLAMMASOME PATHWAY%REACTOME%R-RNO-5660668.1 CLEC7A inflammasome pathway SIGNALING BY NTRK1 (TRKA)%REACTOME%R-RNO-187037.1 Signaling by NTRK1 (TRKA) PEPTIDE HORMONE METABOLISM%REACTOME%R-RNO-2980736.1 Peptide hormone metabolism CELL CYCLE%REACTOME DATABASE ID RELEASE 66%10144722 Cell Cycle TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G1 CELL CYCLE ARREST%REACTOME%R-RNO-6804116.1 TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest INTERLEUKIN-2 SIGNALING%REACTOME%R-RNO-9020558.1 Interleukin-2 signaling DEPURINATION%REACTOME DATABASE ID RELEASE 66%10144975 Depurination G2 M DNA REPLICATION CHECKPOINT%REACTOME%R-RNO-69478.1 G2 M DNA replication checkpoint FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX%REACTOME DATABASE ID RELEASE 66%10145392 Formation of the beta-catenin:TCF transactivating complex ACTIVATION OF THE TFAP2 (AP-2) FAMILY OF TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 66%10146233 Activation of the TFAP2 (AP-2) family of transcription factors ATF6 (ATF6-ALPHA) ACTIVATES CHAPERONES%REACTOME%R-RNO-381033.1 ATF6 (ATF6-alpha) activates chaperones SHC-MEDIATED CASCADE:FGFR2%REACTOME%R-RNO-5654699.1 SHC-mediated cascade:FGFR2 G1 PHASE%REACTOME%R-RNO-69236.1 G1 Phase SYNTHESIS OF CL%REACTOME DATABASE ID RELEASE 66%10145873 Synthesis of CL SIGNALING BY PDGF%REACTOME DATABASE ID RELEASE 66%10145268 Signaling by PDGF SIGNALING BY FGFR%REACTOME DATABASE ID RELEASE 66%10145253 Signaling by FGFR FRS-MEDIATED FGFR3 SIGNALING%REACTOME%R-RNO-5654706.1 FRS-mediated FGFR3 signaling ACTIVATION OF DNA FRAGMENTATION FACTOR%REACTOME DATABASE ID RELEASE 66%10145439 Activation of DNA fragmentation factor CASPASE ACTIVATION VIA EXTRINSIC APOPTOTIC SIGNALLING PATHWAY%REACTOME%R-RNO-5357769.1 Caspase activation via extrinsic apoptotic signalling pathway INTERLEUKIN-21 SIGNALING%REACTOME%R-RNO-9020958.1 Interleukin-21 signaling BETA-CATENIN INDEPENDENT WNT SIGNALING%REACTOME DATABASE ID RELEASE 66%10145579 Beta-catenin independent WNT signaling PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS%REACTOME%R-RNO-73817.1 Purine ribonucleoside monophosphate biosynthesis GRB7 EVENTS IN ERBB2 SIGNALING%REACTOME%R-RNO-1306955.1 GRB7 events in ERBB2 signaling DEFENSINS%REACTOME%R-RNO-1461973.1 Defensins RUNX2 REGULATES BONE DEVELOPMENT%REACTOME DATABASE ID RELEASE 66%10146257 RUNX2 regulates bone development PROPIONYL-COA CATABOLISM%REACTOME DATABASE ID RELEASE 66%10144800 Propionyl-CoA catabolism KANDUTSCH-RUSSELL PATHWAY%REACTOME DATABASE ID RELEASE 66%10146182 Kandutsch-Russell pathway COMPLEMENT CASCADE%REACTOME%R-RNO-166658.1 Complement cascade MYD88 CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 66%10145155 MyD88 cascade initiated on plasma membrane INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS%REACTOME%R-RNO-141405.1 Inhibition of the proteolytic activity of APC C required for the onset of anaphase by mitotic spindle checkpoint components INTESTINAL HEXOSE ABSORPTION%REACTOME%R-RNO-8981373.1 Intestinal hexose absorption DOPAMINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME%R-RNO-212676.1 Dopamine Neurotransmitter Release Cycle MET ACTIVATES RAS SIGNALING%REACTOME DATABASE ID RELEASE 66%10146212 MET activates RAS signaling DAP12 SIGNALING%REACTOME DATABASE ID RELEASE 66%10145432 DAP12 signaling GAB1 SIGNALOSOME%REACTOME DATABASE ID RELEASE 66%10145248 GAB1 signalosome RIPK1-MEDIATED REGULATED NECROSIS%REACTOME%R-RNO-5213460.1 RIPK1-mediated regulated necrosis REGULATION OF PTEN GENE TRANSCRIPTION%REACTOME%R-RNO-8943724.1 Regulation of PTEN gene transcription AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1%REACTOME DATABASE ID RELEASE 66%10145450 Autodegradation of the E3 ubiquitin ligase COP1 GENE EXPRESSION (TRANSCRIPTION)%REACTOME DATABASE ID RELEASE 66%10144751 Gene expression (Transcription) MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES%REACTOME%R-RNO-450282.1 MAPK targets Nuclear events mediated by MAP kinases RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER%REACTOME%R-RNO-76071.1 RNA Polymerase III Transcription Initiation From Type 3 Promoter HSF1-DEPENDENT TRANSACTIVATION%REACTOME%R-RNO-3371571.1 HSF1-dependent transactivation DOWNSTREAM TCR SIGNALING%REACTOME DATABASE ID RELEASE 66%10145375 Downstream TCR signaling P75NTR RECRUITS SIGNALLING COMPLEXES%REACTOME%R-RNO-209543.1 p75NTR recruits signalling complexes CHOLESTEROL BIOSYNTHESIS%REACTOME%R-RNO-191273.1 Cholesterol biosynthesis MEMBRANE TRAFFICKING%REACTOME DATABASE ID RELEASE 66%10145299 Membrane Trafficking HIGHLY CALCIUM PERMEABLE NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%R-RNO-629597.1 Highly calcium permeable nicotinic acetylcholine receptors PHASE 1 - INACTIVATION OF FAST NA+ CHANNELS%REACTOME DATABASE ID RELEASE 66%10146070 Phase 1 - inactivation of fast Na+ channels TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR%REACTOME DATABASE ID RELEASE 66%10145903 Trafficking and processing of endosomal TLR INTEGRATION OF ENERGY METABOLISM%REACTOME%R-RNO-163685.1 Integration of energy metabolism INTERLEUKIN-10 SIGNALING%REACTOME DATABASE ID RELEASE 66%10145687 Interleukin-10 signaling MITOTIC ANAPHASE%REACTOME DATABASE ID RELEASE 66%10145224 Mitotic Anaphase ZINC EFFLUX AND COMPARTMENTALIZATION BY THE SLC30 FAMILY%REACTOME DATABASE ID RELEASE 66%10145653 Zinc efflux and compartmentalization by the SLC30 family GABA A RECEPTOR ACTIVATION%REACTOME%R-RNO-977441.1 GABA A receptor activation INTESTINAL ABSORPTION%REACTOME DATABASE ID RELEASE 66%10145282 Intestinal absorption DEADENYLATION-DEPENDENT MRNA DECAY%REACTOME%R-RNO-429914.1 Deadenylation-dependent mRNA decay EPH-EPHRIN MEDIATED REPULSION OF CELLS%REACTOME%R-RNO-3928665.1 EPH-ephrin mediated repulsion of cells ADRENALINE SIGNALLING THROUGH ALPHA-2 ADRENERGIC RECEPTOR%REACTOME DATABASE ID RELEASE 66%10145560 Adrenaline signalling through Alpha-2 adrenergic receptor MINERALOCORTICOID BIOSYNTHESIS%REACTOME%R-RNO-193993.1 Mineralocorticoid biosynthesis BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 66%10144858 Base Excision Repair INTERLEUKIN-2 FAMILY SIGNALING%REACTOME DATABASE ID RELEASE 66%10145686 Interleukin-2 family signaling POST-TRANSLATIONAL PROTEIN PHOSPHORYLATION%REACTOME DATABASE ID RELEASE 66%10146280 Post-translational protein phosphorylation CELLULAR RESPONSES TO STRESS%REACTOME%R-RNO-2262752.1 Cellular responses to stress RECYCLING OF BILE ACIDS AND SALTS%REACTOME%R-RNO-159418.1 Recycling of bile acids and salts METAL ION SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 66%10145650 Metal ion SLC transporters UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D%REACTOME%R-RNO-75815.1 Ubiquitin-dependent degradation of Cyclin D SIGNALING BY FGFR4%REACTOME DATABASE ID RELEASE 66%10145262 Signaling by FGFR4 SODIUM CALCIUM EXCHANGERS%REACTOME DATABASE ID RELEASE 66%10145617 Sodium Calcium exchangers POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE%REACTOME%R-RNO-174411.1 Polymerase switching on the C-strand of the telomere INTERLEUKIN RECEPTOR SHC SIGNALING%REACTOME%R-RNO-912526.1 Interleukin receptor SHC signaling REGULATION OF KIT SIGNALING%REACTOME%R-RNO-1433559.1 Regulation of KIT signaling TRAF6 MEDIATED NF-KB ACTIVATION%REACTOME%R-RNO-933542.1 TRAF6 mediated NF-kB activation REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS%REACTOME%R-RNO-450531.1 Regulation of mRNA stability by proteins that bind AU-rich elements ANDROGEN BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 66%10145322 Androgen biosynthesis ACYL CHAIN REMODELLING OF PI%REACTOME%R-RNO-1482922.1 Acyl chain remodelling of PI GLUCURONIDATION%REACTOME%R-RNO-156588.1 Glucuronidation SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS%REACTOME%R-RNO-446219.1 Synthesis of substrates in N-glycan biosythesis FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION%REACTOME%R-RNO-983231.1 Factors involved in megakaryocyte development and platelet production MRNA SPLICING%REACTOME DATABASE ID RELEASE 66%10144829 mRNA Splicing FRUCTOSE CATABOLISM%REACTOME%R-RNO-70350.1 Fructose catabolism METABOLISM OF FAT-SOLUBLE VITAMINS%REACTOME DATABASE ID RELEASE 66%10145778 Metabolism of fat-soluble vitamins NGF PROCESSING%REACTOME DATABASE ID RELEASE 66%10145269 NGF processing BETA-CATENIN PHOSPHORYLATION CASCADE%REACTOME%R-RNO-196299.1 Beta-catenin phosphorylation cascade SYNDECAN INTERACTIONS%REACTOME%R-RNO-3000170.1 Syndecan interactions MET RECEPTOR RECYCLING%REACTOME DATABASE ID RELEASE 66%10146253 MET receptor recycling IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX%REACTOME DATABASE ID RELEASE 66%10144904 Import of palmitoyl-CoA into the mitochondrial matrix COSTIMULATION BY THE CD28 FAMILY%REACTOME DATABASE ID RELEASE 66%10145355 Costimulation by the CD28 family G1 S TRANSITION%REACTOME DATABASE ID RELEASE 66%10144724 G1 S Transition PHOSPHO-PLA2 PATHWAY%REACTOME DATABASE ID RELEASE 66%10144988 phospho-PLA2 pathway NRAGE SIGNALS DEATH THROUGH JNK%REACTOME%R-RNO-193648.1 NRAGE signals death through JNK HDR THROUGH HOMOLOGOUS RECOMBINATION (HRR)%REACTOME%R-RNO-5685942.1 HDR through Homologous Recombination (HRR) N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE%REACTOME%R-RNO-532668.1 N-glycan trimming in the ER and Calnexin Calreticulin cycle IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL%REACTOME%R-RNO-198933.1 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell GAMMA-CARBOXYLATION, TRANSPORT, AND AMINO-TERMINAL CLEAVAGE OF PROTEINS%REACTOME DATABASE ID RELEASE 66%10145094 Gamma-carboxylation, transport, and amino-terminal cleavage of proteins NOTCH4 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME DATABASE ID RELEASE 66%10146329 NOTCH4 Activation and Transmission of Signal to the Nucleus PHOSPHATE BOND HYDROLYSIS BY NUDT PROTEINS%REACTOME DATABASE ID RELEASE 66%10145964 Phosphate bond hydrolysis by NUDT proteins NON-INTEGRIN MEMBRANE-ECM INTERACTIONS%REACTOME DATABASE ID RELEASE 66%10145963 Non-integrin membrane-ECM interactions MITOTIC METAPHASE ANAPHASE TRANSITION%REACTOME DATABASE ID RELEASE 66%10145108 Mitotic Metaphase Anaphase Transition CILIUM ASSEMBLY%REACTOME DATABASE ID RELEASE 66%10146080 Cilium Assembly BETA OXIDATION OF MYRISTOYL-COA TO LAUROYL-COA%REACTOME%R-RNO-77285.1 Beta oxidation of myristoyl-CoA to lauroyl-CoA CELLULAR HEXOSE TRANSPORT%REACTOME%R-RNO-189200.1 Cellular hexose transport CARGO CONCENTRATION IN THE ER%REACTOME DATABASE ID RELEASE 66%10146150 Cargo concentration in the ER BIOSYNTHESIS OF SPECIALIZED PRORESOLVING MEDIATORS (SPMS)%REACTOME%R-RNO-9018678.1 Biosynthesis of specialized proresolving mediators (SPMs) DOWNSTREAM SIGNALING OF ACTIVATED FGFR3%REACTOME%R-RNO-5654708.1 Downstream signaling of activated FGFR3 BIOSYNTHESIS OF DHA-DERIVED SULFIDO CONJUGATES%REACTOME%R-RNO-9026395.1 Biosynthesis of DHA-derived sulfido conjugates LOCALIZATION OF THE PINCH-ILK-PARVIN COMPLEX TO FOCAL ADHESIONS%REACTOME%R-RNO-446343.1 Localization of the PINCH-ILK-PARVIN complex to focal adhesions ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT)%REACTOME%R-RNO-917729.1 Endosomal Sorting Complex Required For Transport (ESCRT) MAPK3 (ERK1) ACTIVATION%REACTOME%R-RNO-110056.1 MAPK3 (ERK1) activation PEPTIDE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145486 Peptide ligand-binding receptors BIOSYNTHESIS OF EPA-DERIVED SPMS%REACTOME%R-RNO-9018679.1 Biosynthesis of EPA-derived SPMs HORMONE LIGAND-BINDING RECEPTORS%REACTOME%R-RNO-375281.1 Hormone ligand-binding receptors BIOSYNTHESIS OF DPA-DERIVED SPMS%REACTOME%R-RNO-9018683.1 Biosynthesis of DPA-derived SPMs SIGNALING BY PTK6%REACTOME%R-RNO-8848021.1 Signaling by PTK6 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%R-RNO-975144.1 IRAK1 recruits IKK complex upon TLR7 8 or 9 stimulation ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS%REACTOME%R-RNO-390471.1 Association of TriC CCT with target proteins during biosynthesis NCAM SIGNALING FOR NEURITE OUT-GROWTH%REACTOME DATABASE ID RELEASE 66%10145367 NCAM signaling for neurite out-growth DOWNSTREAM SIGNAL TRANSDUCTION%REACTOME%R-RNO-186763.1 Downstream signal transduction HDR THROUGH HOMOLOGOUS RECOMBINATION (HRR) OR SINGLE STRAND ANNEALING (SSA)%REACTOME%R-RNO-5693567.1 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) NITRIC OXIDE STIMULATES GUANYLATE CYCLASE%REACTOME DATABASE ID RELEASE 66%10145601 Nitric oxide stimulates guanylate cyclase ER QUALITY CONTROL COMPARTMENT (ERQC)%REACTOME DATABASE ID RELEASE 66%10145712 ER Quality Control Compartment (ERQC) TRAFFICKING OF AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145593 Trafficking of AMPA receptors GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE%REACTOME%R-RNO-210500.1 Glutamate Neurotransmitter Release Cycle RAP1 SIGNALLING%REACTOME DATABASE ID RELEASE 66%10145480 Rap1 signalling MISMATCH REPAIR (MMR) DIRECTED BY MSH2:MSH6 (MUTSALPHA)%REACTOME DATABASE ID RELEASE 66%10146059 Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) INTERLEUKIN-36 PATHWAY%REACTOME%R-RNO-9014826.1 Interleukin-36 pathway SYNTHESIS OF PG%REACTOME%R-RNO-1483148.1 Synthesis of PG SYNTHESIS OF PI%REACTOME%R-RNO-1483226.1 Synthesis of PI SYNTHESIS OF ACTIVE UBIQUITIN: ROLES OF E1 AND E2 ENZYMES%REACTOME DATABASE ID RELEASE 66%10146214 Synthesis of active ubiquitin: roles of E1 and E2 enzymes CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE%REACTOME%R-RNO-442720.1 CREB phosphorylation through the activation of Adenylate Cyclase TNFR1-INDUCED NFKAPPAB SIGNALING PATHWAY%REACTOME DATABASE ID RELEASE 66%10146055 TNFR1-induced NFkappaB signaling pathway BIOSYNTHESIS OF MARESIN-LIKE SPMS%REACTOME DATABASE ID RELEASE 66%10146318 Biosynthesis of maresin-like SPMs CONJUGATION OF BENZOATE WITH GLYCINE%REACTOME%R-RNO-177135.1 Conjugation of benzoate with glycine ABC-FAMILY PROTEINS MEDIATED TRANSPORT%REACTOME DATABASE ID RELEASE 66%10145462 ABC-family proteins mediated transport TRANSPORT OF GLYCEROL FROM ADIPOCYTES TO THE LIVER BY AQUAPORINS%REACTOME DATABASE ID RELEASE 66%10145643 Transport of glycerol from adipocytes to the liver by Aquaporins DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE%REACTOME%R-RNO-606279.1 Deposition of new CENPA-containing nucleosomes at the centromere INTERCONVERSION OF 2-OXOGLUTARATE AND 2-HYDROXYGLUTARATE%REACTOME%R-RNO-880009.1 Interconversion of 2-oxoglutarate and 2-hydroxyglutarate HS-GAG DEGRADATION%REACTOME%R-RNO-2024096.1 HS-GAG degradation GABA B RECEPTOR ACTIVATION%REACTOME%R-RNO-977444.1 GABA B receptor activation GLYCEROPHOSPHOLIPID CATABOLISM%REACTOME DATABASE ID RELEASE 66%10146195 Glycerophospholipid catabolism PI3K AKT SIGNALING%REACTOME%R-RNO-1257604.1 PI3K AKT Signaling SUMOYLATION OF TRANSCRIPTION FACTORS%REACTOME%R-RNO-3232118.1 SUMOylation of transcription factors M PHASE%REACTOME%R-RNO-68886.1 M Phase ACTIVATION OF BID AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%R-RNO-75108.1 Activation of BID and translocation to mitochondria FGFR1C AND KLOTHO LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 66%10145295 FGFR1c and Klotho ligand binding and activation INTRAFLAGELLAR TRANSPORT%REACTOME%R-RNO-5620924.1 Intraflagellar transport BETA OXIDATION OF PALMITOYL-COA TO MYRISTOYL-COA%REACTOME DATABASE ID RELEASE 66%10144934 Beta oxidation of palmitoyl-CoA to myristoyl-CoA SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE%REACTOME DATABASE ID RELEASE 66%10145902 Synthesis of PIPs at the early endosome membrane RNA POLYMERASE II TRANSCRIPTION ELONGATION%REACTOME%R-RNO-75955.1 RNA Polymerase II Transcription Elongation TOLL LIKE RECEPTOR 5 (TLR5) CASCADE%REACTOME DATABASE ID RELEASE 66%10145157 Toll Like Receptor 5 (TLR5) Cascade GLUCOCORTICOID BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 66%10145323 Glucocorticoid biosynthesis REACTIONS SPECIFIC TO THE COMPLEX N-GLYCAN SYNTHESIS PATHWAY%REACTOME DATABASE ID RELEASE 66%10145779 Reactions specific to the complex N-glycan synthesis pathway SIGNALING BY INTERLEUKINS%REACTOME DATABASE ID RELEASE 66%10145163 Signaling by Interleukins DETOXIFICATION OF REACTIVE OXYGEN SPECIES%REACTOME%R-RNO-3299685.1 Detoxification of Reactive Oxygen Species PLASMA LIPOPROTEIN CLEARANCE%REACTOME%R-RNO-8964043.1 Plasma lipoprotein clearance PEROXISOMAL LIPID METABOLISM%REACTOME%R-RNO-390918.1 Peroxisomal lipid metabolism GAP JUNCTION ASSEMBLY%REACTOME%R-RNO-190861.1 Gap junction assembly DNA DAMAGE RECOGNITION IN GG-NER%REACTOME DATABASE ID RELEASE 66%10146144 DNA Damage Recognition in GG-NER MITOTIC METAPHASE AND ANAPHASE%REACTOME DATABASE ID RELEASE 66%10145109 Mitotic Metaphase and Anaphase POST NMDA RECEPTOR ACTIVATION EVENTS%REACTOME%R-RNO-438064.1 Post NMDA receptor activation events MAP KINASE ACTIVATION%REACTOME DATABASE ID RELEASE 66%10145160 MAP kinase activation NUCLEOBASE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 66%10144842 Nucleobase biosynthesis MITOCHONDRIAL TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 66%10145689 Mitochondrial tRNA aminoacylation PI3K AKT ACTIVATION%REACTOME DATABASE ID RELEASE 66%10145352 PI3K AKT activation PTK6 REGULATES PROTEINS INVOLVED IN RNA PROCESSING%REACTOME DATABASE ID RELEASE 66%10146207 PTK6 Regulates Proteins Involved in RNA Processing CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE%REACTOME%R-RNO-204998.1 Cell death signalling via NRAGE, NRIF and NADE SELENOAMINO ACID METABOLISM%REACTOME%R-RNO-2408522.1 Selenoamino acid metabolism CELL CYCLE CHECKPOINTS%REACTOME DATABASE ID RELEASE 66%10144741 Cell Cycle Checkpoints NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC)%REACTOME%R-RNO-975957.1 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) INTERLEUKIN-18 SIGNALING%REACTOME%R-RNO-9012546.1 Interleukin-18 signaling FRS-MEDIATED FGFR2 SIGNALING%REACTOME DATABASE ID RELEASE 66%10146103 FRS-mediated FGFR2 signaling BASE-EXCISION REPAIR, AP SITE FORMATION%REACTOME%R-RNO-73929.1 Base-Excision Repair, AP Site Formation RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER%REACTOME DATABASE ID RELEASE 66%10144947 RNA Polymerase III Transcription Initiation From Type 2 Promoter CYP2E1 REACTIONS%REACTOME%R-RNO-211999.1 CYP2E1 reactions TRANSLATION INITIATION COMPLEX FORMATION%REACTOME DATABASE ID RELEASE 66%10145076 Translation initiation complex formation UNBLOCKING OF NMDA RECEPTORS, GLUTAMATE BINDING AND ACTIVATION%REACTOME%R-RNO-438066.1 Unblocking of NMDA receptors, glutamate binding and activation CAMK IV-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%R-RNO-111932.1 CaMK IV-mediated phosphorylation of CREB LYSOSPHINGOLIPID AND LPA RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145608 Lysosphingolipid and LPA receptors METABOLISM OF INGESTED SEMET, SEC, MESEC INTO H2SE%REACTOME%R-RNO-2408508.1 Metabolism of ingested SeMet, Sec, MeSec into H2Se GLYCOSAMINOGLYCAN METABOLISM%REACTOME%R-RNO-1630316.1 Glycosaminoglycan metabolism RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 66%10144983 Resolution of AP sites via the multiple-nucleotide patch replacement pathway IGF1R SIGNALING CASCADE%REACTOME%R-RNO-2428924.1 IGF1R signaling cascade CELLULAR RESPONSES TO EXTERNAL STIMULI%REACTOME%R-RNO-8953897.1 Cellular responses to external stimuli CHYLOMICRON CLEARANCE%REACTOME%R-RNO-8964026.1 Chylomicron clearance HIGHLY SODIUM PERMEABLE ACETYLCHOLINE NICOTINIC RECEPTORS%REACTOME%R-RNO-629587.1 Highly sodium permeable acetylcholine nicotinic receptors NEGATIVE REGULATION OF MAPK PATHWAY%REACTOME%R-RNO-5675221.1 Negative regulation of MAPK pathway SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE%REACTOME DATABASE ID RELEASE 66%10145899 Synthesis of PIPs at the late endosome membrane ACETYLCHOLINE REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 66%10145585 Acetylcholine regulates insulin secretion RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS%REACTOME%R-RNO-674695.1 RNA Polymerase II Pre-transcription Events REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA)%REACTOME DATABASE ID RELEASE 66%10145590 Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) CONJUGATION OF SALICYLATE WITH GLYCINE%REACTOME%R-RNO-177128.1 Conjugation of salicylate with glycine CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY%REACTOME DATABASE ID RELEASE 66%10145212 Cyclin A:Cdk2-associated events at S phase entry NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 66%10145513 Nuclear Receptor transcription pathway AURKA ACTIVATION BY TPX2%REACTOME%R-RNO-8854518.1 AURKA Activation by TPX2 FATTY ACIDS%REACTOME%R-RNO-211935.1 Fatty acids MITOTIC PROPHASE%REACTOME DATABASE ID RELEASE 66%10145525 Mitotic Prophase THE RETINOID CYCLE IN CONES (DAYLIGHT VISION)%REACTOME DATABASE ID RELEASE 66%10145969 The retinoid cycle in cones (daylight vision) TERMINATION OF O-GLYCAN BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 66%10145784 Termination of O-glycan biosynthesis GLYCOGEN METABOLISM%REACTOME DATABASE ID RELEASE 66%10144770 Glycogen metabolism INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES%REACTOME%R-RNO-499943.1 Interconversion of nucleotide di- and triphosphates N-GLYCAN ANTENNAE ELONGATION%REACTOME DATABASE ID RELEASE 66%10145781 N-Glycan antennae elongation O-LINKED GLYCOSYLATION%REACTOME%R-RNO-5173105.1 O-linked glycosylation DNA REPLICATION INITIATION%REACTOME DATABASE ID RELEASE 66%10144718 DNA replication initiation PURINE SALVAGE%REACTOME DATABASE ID RELEASE 66%10144873 Purine salvage G-PROTEIN BETA:GAMMA SIGNALLING%REACTOME%R-RNO-397795.1 G-protein beta:gamma signalling ALTERNATIVE COMPLEMENT ACTIVATION%REACTOME DATABASE ID RELEASE 66%10145211 Alternative complement activation SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP)%REACTOME DATABASE ID RELEASE 66%10145264 Senescence-Associated Secretory Phenotype (SASP) SIGNALING BY INSULIN RECEPTOR%REACTOME%R-RNO-74752.1 Signaling by Insulin receptor SIGNALING BY NODAL%REACTOME%R-RNO-1181150.1 Signaling by NODAL PI3K EVENTS IN ERBB2 SIGNALING%REACTOME DATABASE ID RELEASE 66%10145823 PI3K events in ERBB2 signaling U12 DEPENDENT SPLICING%REACTOME%R-RNO-72165.1 U12 Dependent Splicing RHO GTPASES ACTIVATE PKNS%REACTOME%R-RNO-5625740.1 RHO GTPases activate PKNs C6 DEAMINATION OF ADENOSINE%REACTOME%R-RNO-75102.1 C6 deamination of adenosine SERINE BIOSYNTHESIS%REACTOME%R-RNO-977347.1 Serine biosynthesis NEGATIVE REGULATION OF THE PI3K AKT NETWORK%REACTOME%R-RNO-199418.1 Negative regulation of the PI3K AKT network METABOLISM OF FOLATE AND PTERINES%REACTOME%R-RNO-196757.1 Metabolism of folate and pterines ACTIVATION OF C3 AND C5%REACTOME%R-RNO-174577.1 Activation of C3 and C5 SHC-MEDIATED CASCADE:FGFR3%REACTOME%R-RNO-5654704.1 SHC-mediated cascade:FGFR3 BIOLOGICAL OXIDATIONS%REACTOME%R-RNO-211859.1 Biological oxidations NONCANONICAL ACTIVATION OF NOTCH3%REACTOME%R-RNO-9017802.1 Noncanonical activation of NOTCH3 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION)%REACTOME%R-RNO-2453902.1 The canonical retinoid cycle in rods (twilight vision) REGULATION OF TNFR1 SIGNALING%REACTOME DATABASE ID RELEASE 66%10146056 Regulation of TNFR1 signaling RNA POLYMERASE II PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 66%10144902 RNA Polymerase II Promoter Escape SUMOYLATION OF DNA METHYLATION PROTEINS%REACTOME%R-RNO-4655427.1 SUMOylation of DNA methylation proteins RUNX1 REGULATES ESTROGEN RECEPTOR MEDIATED TRANSCRIPTION%REACTOME DATABASE ID RELEASE 66%10146262 RUNX1 regulates estrogen receptor mediated transcription THREONINE CATABOLISM%REACTOME DATABASE ID RELEASE 66%10146296 Threonine catabolism METABOLISM OF RNA%REACTOME DATABASE ID RELEASE 66%10144827 Metabolism of RNA SYNTHESIS OF DOLICHYL-PHOSPHATE MANNOSE%REACTOME DATABASE ID RELEASE 66%10145103 Synthesis of dolichyl-phosphate mannose RNA POLYMERASE III TRANSCRIPTION INITIATION%REACTOME%R-RNO-76046.1 RNA Polymerase III Transcription Initiation ADENOSINE P1 RECEPTORS%REACTOME%R-RNO-417973.1 Adenosine P1 receptors WAX BIOSYNTHESIS%REACTOME%R-RNO-8848584.1 Wax biosynthesis ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 66%10145451 Acetylcholine Neurotransmitter Release Cycle TRAIL SIGNALING%REACTOME%R-RNO-75158.1 TRAIL signaling DIGESTION%REACTOME DATABASE ID RELEASE 66%10145278 Digestion CELLULAR SENESCENCE%REACTOME%R-RNO-2559583.1 Cellular Senescence G ALPHA (S) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 66%10145517 G alpha (s) signalling events TNFR1-MEDIATED CERAMIDE PRODUCTION%REACTOME DATABASE ID RELEASE 66%10146089 TNFR1-mediated ceramide production SIGNALING BY RETINOIC ACID%REACTOME DATABASE ID RELEASE 66%10145381 Signaling by Retinoic Acid DIMERIZATION OF PROCASPASE-8%REACTOME%R-RNO-69416.1 Dimerization of procaspase-8 REGULATION OF GAP JUNCTION ACTIVITY%REACTOME DATABASE ID RELEASE 66%10145308 Regulation of gap junction activity PROLONGED ERK ACTIVATION EVENTS%REACTOME DATABASE ID RELEASE 66%10145181 Prolonged ERK activation events RELEASE OF APOPTOTIC FACTORS FROM THE MITOCHONDRIA%REACTOME DATABASE ID RELEASE 66%10145018 Release of apoptotic factors from the mitochondria SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE%REACTOME%R-RNO-1660499.1 Synthesis of PIPs at the plasma membrane TRANSPORT AND SYNTHESIS OF PAPS%REACTOME%R-RNO-174362.1 Transport and synthesis of PAPS DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING%REACTOME DATABASE ID RELEASE 66%10145207 Downregulation of TGF-beta receptor signaling SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI)%REACTOME%R-RNO-162710.1 Synthesis of glycosylphosphatidylinositol (GPI) INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS%REACTOME%R-RNO-997272.1 Inhibition of voltage gated Ca2+ channels via Gbeta gamma subunits PROTON-COUPLED NEUTRAL AMINO ACID TRANSPORTERS%REACTOME DATABASE ID RELEASE 66%10145510 Proton-coupled neutral amino acid transporters ERYTHROPOIETIN ACTIVATES PHOSPHOINOSITIDE-3-KINASE (PI3K)%REACTOME DATABASE ID RELEASE 66%10146294 Erythropoietin activates Phosphoinositide-3-kinase (PI3K) METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS%REACTOME DATABASE ID RELEASE 66%10145925 Metabolism of Angiotensinogen to Angiotensins ION CHANNEL TRANSPORT%REACTOME DATABASE ID RELEASE 66%10145600 Ion channel transport CREB3 FACTORS ACTIVATE GENES%REACTOME DATABASE ID RELEASE 66%10146248 CREB3 factors activate genes ORC1 REMOVAL FROM CHROMATIN%REACTOME%R-RNO-68949.1 Orc1 removal from chromatin SIGNALING BY FGFR2%REACTOME DATABASE ID RELEASE 66%10145256 Signaling by FGFR2 AMINE OXIDASE REACTIONS%REACTOME DATABASE ID RELEASE 66%10145056 Amine Oxidase reactions TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION%REACTOME%R-RNO-948021.1 Transport to the Golgi and subsequent modification L1CAM INTERACTIONS%REACTOME DATABASE ID RELEASE 66%10144965 L1CAM interactions PROLACTIN RECEPTOR SIGNALING%REACTOME DATABASE ID RELEASE 66%10145783 Prolactin receptor signaling ACETYLATION%REACTOME DATABASE ID RELEASE 66%10145083 Acetylation CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII%REACTOME DATABASE ID RELEASE 66%10145658 CREB phosphorylation through the activation of CaMKII FORMATION OF XYLULOSE-5-PHOSPHATE%REACTOME DATABASE ID RELEASE 66%10146116 Formation of xylulose-5-phosphate BETA DEFENSINS%REACTOME DATABASE ID RELEASE 66%10145858 Beta defensins GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY%REACTOME%R-RNO-399721.1 Glutamate binding, activation of AMPA receptors and synaptic plasticity STRIATED MUSCLE CONTRACTION%REACTOME%R-RNO-390522.1 Striated Muscle Contraction ABC TRANSPORTERS IN LIPID HOMEOSTASIS%REACTOME DATABASE ID RELEASE 66%10145461 ABC transporters in lipid homeostasis RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF MYELOID CELLS%REACTOME DATABASE ID RELEASE 66%10146266 RUNX1 regulates transcription of genes involved in differentiation of myeloid cells ESR-MEDIATED SIGNALING%REACTOME DATABASE ID RELEASE 66%10145830 ESR-mediated signaling G ALPHA (Q) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 66%10145036 G alpha (q) signalling events PI3K EVENTS IN ERBB4 SIGNALING%REACTOME%R-RNO-1250342.1 PI3K events in ERBB4 signaling CGMP EFFECTS%REACTOME%R-RNO-418457.1 cGMP effects INTERACTION BETWEEN PHLDA1 AND AURKA%REACTOME DATABASE ID RELEASE 66%10146219 Interaction between PHLDA1 and AURKA G-PROTEIN MEDIATED EVENTS%REACTOME%R-RNO-112040.1 G-protein mediated events ERBB2 REGULATES CELL MOTILITY%REACTOME DATABASE ID RELEASE 66%10146156 ERBB2 Regulates Cell Motility S PHASE%REACTOME%R-RNO-69242.1 S Phase IL-6-TYPE CYTOKINE RECEPTOR LIGAND INTERACTIONS%REACTOME DATABASE ID RELEASE 66%10145682 IL-6-type cytokine receptor ligand interactions VESICLE-MEDIATED TRANSPORT%REACTOME DATABASE ID RELEASE 66%10145300 Vesicle-mediated transport CONJUGATION OF PHENYLACETATE WITH GLUTAMINE%REACTOME DATABASE ID RELEASE 66%10145246 Conjugation of phenylacetate with glutamine SIGNALING BY FGFR1%REACTOME%R-RNO-5654736.1 Signaling by FGFR1 RNA POLYMERASE I CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 66%10144884 RNA Polymerase I Chain Elongation INTERLEUKIN-17 SIGNALING%REACTOME%R-RNO-448424.1 Interleukin-17 signaling HDMS DEMETHYLATE HISTONES%REACTOME DATABASE ID RELEASE 66%10145998 HDMs demethylate histones RNA POLYMERASE I TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 66%10144850 RNA Polymerase I Transcription Initiation SCAVENGING OF HEME FROM PLASMA%REACTOME%R-RNO-2168880.1 Scavenging of heme from plasma MAP3K8 (TPL2)-DEPENDENT MAPK1 3 ACTIVATION%REACTOME DATABASE ID RELEASE 66%10145702 MAP3K8 (TPL2)-dependent MAPK1 3 activation SYNTHESIS OF 5-EICOSATETRAENOIC ACIDS%REACTOME%R-RNO-2142688.1 Synthesis of 5-eicosatetraenoic acids MYOGENESIS%REACTOME%R-RNO-525793.1 Myogenesis CHONDROITIN SULFATE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 66%10145919 Chondroitin sulfate biosynthesis SIGNALING BY LEPTIN%REACTOME DATABASE ID RELEASE 66%10145709 Signaling by Leptin ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1%REACTOME DATABASE ID RELEASE 66%10145597 ADP signalling through P2Y purinoceptor 1 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE%REACTOME%R-RNO-2559586.1 DNA Damage Telomere Stress Induced Senescence FATTY ACYL-COA BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 66%10144901 Fatty acyl-CoA biosynthesis P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME%R-RNO-69580.1 p53-Dependent G1 S DNA damage checkpoint RSK ACTIVATION%REACTOME DATABASE ID RELEASE 66%10145660 RSK activation PROCESSING OF CAPPED INTRONLESS PRE-MRNA%REACTOME%R-RNO-75067.1 Processing of Capped Intronless Pre-mRNA DUAL INCISION IN GG-NER%REACTOME DATABASE ID RELEASE 66%10146140 Dual Incision in GG-NER CONDENSATION OF PROPHASE CHROMOSOMES%REACTOME DATABASE ID RELEASE 66%10145955 Condensation of Prophase Chromosomes REGULATION OF TP53 ACTIVITY%REACTOME%R-RNO-5633007.1 Regulation of TP53 Activity MICROTUBULE-DEPENDENT TRAFFICKING OF CONNEXONS FROM GOLGI TO THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 66%10145301 Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane ER TO GOLGI ANTEROGRADE TRANSPORT%REACTOME%R-RNO-199977.1 ER to Golgi Anterograde Transport IRON UPTAKE AND TRANSPORT%REACTOME DATABASE ID RELEASE 66%10145283 Iron uptake and transport CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION%REACTOME DATABASE ID RELEASE 66%10145415 Class I MHC mediated antigen processing & presentation POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%R-RNO-622327.1 Postsynaptic nicotinic acetylcholine receptors INTERLEUKIN-15 SIGNALING%REACTOME%R-RNO-8983432.1 Interleukin-15 signaling CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE%REACTOME%R-RNO-176407.1 Conversion from APC C:Cdc20 to APC C:Cdh1 in late anaphase ACTIVATED NTRK2 SIGNALS THROUGH FYN%REACTOME DATABASE ID RELEASE 66%10146323 Activated NTRK2 signals through FYN MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF SATURATED FATTY ACIDS%REACTOME%R-RNO-77286.1 mitochondrial fatty acid beta-oxidation of saturated fatty acids MET ACTIVATES RAP1 AND RAC1%REACTOME DATABASE ID RELEASE 66%10146252 MET activates RAP1 and RAC1 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION%REACTOME%R-RNO-156827.1 L13a-mediated translational silencing of Ceruloplasmin expression HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME%R-RNO-5693579.1 Homologous DNA Pairing and Strand Exchange P75NTR SIGNALS VIA NF-KB%REACTOME%R-RNO-193639.1 p75NTR signals via NF-kB CELL-CELL COMMUNICATION%REACTOME DATABASE ID RELEASE 66%10145431 Cell-Cell communication RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASES%REACTOME DATABASE ID RELEASE 66%10145543 Receptor-type tyrosine-protein phosphatases SULFIDE OXIDATION TO SULFATE%REACTOME DATABASE ID RELEASE 66%10145889 Sulfide oxidation to sulfate SIGNALING BY EGFR%REACTOME DATABASE ID RELEASE 66%10144957 Signaling by EGFR INVADOPODIA FORMATION%REACTOME DATABASE ID RELEASE 66%10146271 Invadopodia formation P53-DEPENDENT G1 DNA DAMAGE RESPONSE%REACTOME%R-RNO-69563.1 p53-Dependent G1 DNA Damage Response METAL SEQUESTRATION BY ANTIMICROBIAL PROTEINS%REACTOME DATABASE ID RELEASE 66%10145804 Metal sequestration by antimicrobial proteins SUMOYLATION OF IMMUNE RESPONSE PROTEINS%REACTOME%R-RNO-4755510.1 SUMOylation of immune response proteins LYSINE CATABOLISM%REACTOME%R-RNO-71064.1 Lysine catabolism ARL13B-MEDIATED CILIARY TRAFFICKING OF INPP5E%REACTOME DATABASE ID RELEASE 66%10146085 ARL13B-mediated ciliary trafficking of INPP5E TRANSPORT OF FATTY ACIDS%REACTOME%R-RNO-804914.1 Transport of fatty acids COPI-DEPENDENT GOLGI-TO-ER RETROGRADE TRAFFIC%REACTOME%R-RNO-6811434.1 COPI-dependent Golgi-to-ER retrograde traffic METABOLISM OF PROTEINS%REACTOME DATABASE ID RELEASE 66%10144825 Metabolism of proteins IRF3-MEDIATED INDUCTION OF TYPE I IFN%REACTOME DATABASE ID RELEASE 66%10145930 IRF3-mediated induction of type I IFN REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION%REACTOME%R-RNO-2565942.1 Regulation of PLK1 Activity at G2 M Transition INTERLEUKIN-33 SIGNALING%REACTOME%R-RNO-9014843.1 Interleukin-33 signaling MHC CLASS II ANTIGEN PRESENTATION%REACTOME DATABASE ID RELEASE 66%10145936 MHC class II antigen presentation DNA REPLICATION%REACTOME%R-RNO-69306.1 DNA Replication ARYL HYDROCARBON RECEPTOR SIGNALLING%REACTOME DATABASE ID RELEASE 66%10146264 Aryl hydrocarbon receptor signalling ISG15 ANTIVIRAL MECHANISM%REACTOME DATABASE ID RELEASE 66%10145800 ISG15 antiviral mechanism GENERIC TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 66%10144749 Generic Transcription Pathway ACYL CHAIN REMODELING OF CL%REACTOME%R-RNO-1482798.1 Acyl chain remodeling of CL VOLTAGE GATED POTASSIUM CHANNELS%REACTOME DATABASE ID RELEASE 66%10145837 Voltage gated Potassium channels ADHERENS JUNCTIONS INTERACTIONS%REACTOME DATABASE ID RELEASE 66%10145606 Adherens junctions interactions BETA-OXIDATION OF PRISTANOYL-COA%REACTOME%R-RNO-389887.1 Beta-oxidation of pristanoyl-CoA SEMA4D IN SEMAPHORIN SIGNALING%REACTOME%R-RNO-400685.1 Sema4D in semaphorin signaling TRANSCRIPTIONAL REGULATION BY E2F6%REACTOME%R-RNO-8953750.1 Transcriptional Regulation by E2F6 SUMOYLATION OF DNA DAMAGE RESPONSE AND REPAIR PROTEINS%REACTOME%R-RNO-3108214.1 SUMOylation of DNA damage response and repair proteins ERK1 ERK2 PATHWAY%REACTOME DATABASE ID RELEASE 66%10144961 ERK1 ERK2 pathway TOLL LIKE RECEPTOR 9 (TLR9) CASCADE%REACTOME DATABASE ID RELEASE 66%10145153 Toll Like Receptor 9 (TLR9) Cascade GLUCAGON SIGNALING IN METABOLIC REGULATION%REACTOME DATABASE ID RELEASE 66%10145003 Glucagon signaling in metabolic regulation ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION%REACTOME DATABASE ID RELEASE 66%10145786 Antigen processing: Ubiquitination & Proteasome degradation GAP JUNCTION TRAFFICKING%REACTOME%R-RNO-190828.1 Gap junction trafficking REGULATION OF PTEN STABILITY AND ACTIVITY%REACTOME DATABASE ID RELEASE 66%10146185 Regulation of PTEN stability and activity EXTRINSIC PATHWAY OF FIBRIN CLOT FORMATION%REACTOME DATABASE ID RELEASE 66%10145054 Extrinsic Pathway of Fibrin Clot Formation MITOCHONDRIAL TRANSLATION ELONGATION%REACTOME DATABASE ID RELEASE 66%10146063 Mitochondrial translation elongation TRANSFER OF LPS FROM LBP CARRIER TO CD14%REACTOME%R-RNO-166020.1 Transfer of LPS from LBP carrier to CD14 ENOS ACTIVATION AND REGULATION%REACTOME%R-RNO-203765.1 eNOS activation and regulation G2 M TRANSITION%REACTOME%R-RNO-69275.1 G2 M Transition SYNTHESIS OF GDP-MANNOSE%REACTOME DATABASE ID RELEASE 66%10145672 Synthesis of GDP-mannose PI-3K CASCADE:FGFR3%REACTOME DATABASE ID RELEASE 66%10145257 PI-3K cascade:FGFR3 PAOS OXIDISE POLYAMINES TO AMINES%REACTOME DATABASE ID RELEASE 66%10145060 PAOs oxidise polyamines to amines DOWNREGULATION OF ERBB4 SIGNALING%REACTOME DATABASE ID RELEASE 66%10145828 Downregulation of ERBB4 signaling REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION%REACTOME%R-RNO-2029482.1 Regulation of actin dynamics for phagocytic cup formation TERMINAL PATHWAY OF COMPLEMENT%REACTOME DATABASE ID RELEASE 66%10145210 Terminal pathway of complement REGULATION OF RUNX1 EXPRESSION AND ACTIVITY%REACTOME%R-RNO-8934593.1 Regulation of RUNX1 Expression and Activity INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%R-RNO-2514859.1 Inactivation, recovery and regulation of the phototransduction cascade GENERATION OF SECOND MESSENGER MOLECULES%REACTOME DATABASE ID RELEASE 66%10145400 Generation of second messenger molecules MITOCHONDRIAL TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 66%10145119 Mitochondrial transcription termination CLEAVAGE OF THE DAMAGED PYRIMIDINE%REACTOME%R-RNO-110329.1 Cleavage of the damaged pyrimidine INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME DATABASE ID RELEASE 66%10145016 Intrinsic Pathway for Apoptosis PHASE 3 - RAPID REPOLARISATION%REACTOME%R-RNO-5576890.1 Phase 3 - rapid repolarisation TRANSLESION SYNTHESIS BY POLH%REACTOME%R-RNO-110320.1 Translesion Synthesis by POLH PLATELET CALCIUM HOMEOSTASIS%REACTOME%R-RNO-418360.1 Platelet calcium homeostasis NUCLEAR ENVELOPE REASSEMBLY%REACTOME%R-RNO-2995410.1 Nuclear Envelope Reassembly DAG AND IP3 SIGNALING%REACTOME%R-RNO-1489509.1 DAG and IP3 signaling ION INFLUX EFFLUX AT HOST-PATHOGEN INTERFACE%REACTOME%R-RNO-6803544.1 Ion influx efflux at host-pathogen interface GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER%REACTOME DATABASE ID RELEASE 66%10146143 Gap-filling DNA repair synthesis and ligation in GG-NER PYRIMIDINE CATABOLISM%REACTOME%R-RNO-73621.1 Pyrimidine catabolism GLYCOLYSIS%REACTOME DATABASE ID RELEASE 66%10144768 Glycolysis MOLECULES ASSOCIATED WITH ELASTIC FIBRES%REACTOME DATABASE ID RELEASE 66%10145882 Molecules associated with elastic fibres OXIDATIVE DEMETHYLATION OF DNA%REACTOME DATABASE ID RELEASE 66%10146048 Oxidative demethylation of DNA TRANSPORT OF CONNEXONS TO THE PLASMA MEMBRANE%REACTOME%R-RNO-190872.1 Transport of connexons to the plasma membrane RRNA PROCESSING%REACTOME DATABASE ID RELEASE 66%10146163 rRNA processing AGMATINE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 66%10145466 Agmatine biosynthesis MUSCARINIC ACETYLCHOLINE RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145559 Muscarinic acetylcholine receptors ACTIVATED NTRK2 SIGNALS THROUGH PLCG1%REACTOME%R-RNO-9026527.1 Activated NTRK2 signals through PLCG1 KETONE BODY METABOLISM%REACTOME DATABASE ID RELEASE 66%10144854 Ketone body metabolism TYPE II NA+ PI COTRANSPORTERS%REACTOME DATABASE ID RELEASE 66%10145628 Type II Na+ Pi cotransporters TRAF3-DEPENDENT IRF ACTIVATION PATHWAY%REACTOME DATABASE ID RELEASE 66%10145795 TRAF3-dependent IRF activation pathway ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX%REACTOME%R-RNO-68867.1 Assembly of the pre-replicative complex SYNTHESIS OF PC%REACTOME DATABASE ID RELEASE 66%10145452 Synthesis of PC HYALURONAN UPTAKE AND DEGRADATION%REACTOME%R-RNO-2160916.1 Hyaluronan uptake and degradation SIGNALING BY NOTCH1%REACTOME DATABASE ID RELEASE 66%10145913 Signaling by NOTCH1 PASSIVE TRANSPORT BY AQUAPORINS%REACTOME DATABASE ID RELEASE 66%10145707 Passive transport by Aquaporins NCAM1 INTERACTIONS%REACTOME DATABASE ID RELEASE 66%10145505 NCAM1 interactions SIALIC ACID METABOLISM%REACTOME DATABASE ID RELEASE 66%10145633 Sialic acid metabolism G1 S DNA DAMAGE CHECKPOINTS%REACTOME DATABASE ID RELEASE 66%10144740 G1 S DNA Damage Checkpoints SODIUM-COUPLED PHOSPHATE COTRANSPORTERS%REACTOME DATABASE ID RELEASE 66%10145627 Sodium-coupled phosphate cotransporters REGULATION OF COMMISSURAL AXON PATHFINDING BY SLIT AND ROBO%REACTOME DATABASE ID RELEASE 66%10145632 Regulation of commissural axon pathfinding by SLIT and ROBO REGULATION OF PTEN LOCALIZATION%REACTOME%R-RNO-8948747.1 Regulation of PTEN localization PHASE II - CONJUGATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 66%10144773 Phase II - Conjugation of compounds TRANSFERRIN ENDOCYTOSIS AND RECYCLING%REACTOME%R-RNO-917977.1 Transferrin endocytosis and recycling NECTIN NECL TRANS HETERODIMERIZATION%REACTOME DATABASE ID RELEASE 66%10145613 Nectin Necl trans heterodimerization REGULATION OF FZD BY UBIQUITINATION%REACTOME DATABASE ID RELEASE 66%10146037 Regulation of FZD by ubiquitination FGFR3B LIGAND BINDING AND ACTIVATION%REACTOME%R-RNO-190371.1 FGFR3b ligand binding and activation ION HOMEOSTASIS%REACTOME DATABASE ID RELEASE 66%10145041 Ion homeostasis DEVELOPMENTAL BIOLOGY%REACTOME DATABASE ID RELEASE 66%10144967 Developmental Biology GPCR DOWNSTREAM SIGNALLING%REACTOME DATABASE ID RELEASE 66%10144869 GPCR downstream signalling PHOSPHATE BOND HYDROLYSIS BY NTPDASE PROTEINS%REACTOME DATABASE ID RELEASE 66%10146210 Phosphate bond hydrolysis by NTPDase proteins ANTAGONISM OF ACTIVIN BY FOLLISTATIN%REACTOME%R-RNO-2473224.1 Antagonism of Activin by Follistatin PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR%REACTOME%R-RNO-392851.1 Prostacyclin signalling through prostacyclin receptor CHOLINE CATABOLISM%REACTOME%R-RNO-6798163.1 Choline catabolism MULTIFUNCTIONAL ANION EXCHANGERS%REACTOME DATABASE ID RELEASE 66%10145626 Multifunctional anion exchangers TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 66%10144823 tRNA Aminoacylation OLFACTORY SIGNALING PATHWAY%REACTOME%R-RNO-381753.1 Olfactory Signaling Pathway VLDLR INTERNALISATION AND DEGRADATION%REACTOME%R-RNO-8866427.1 VLDLR internalisation and degradation BETA OXIDATION OF HEXANOYL-COA TO BUTANOYL-COA%REACTOME%R-RNO-77350.1 Beta oxidation of hexanoyl-CoA to butanoyl-CoA FANCONI ANEMIA PATHWAY%REACTOME%R-RNO-6783310.1 Fanconi Anemia Pathway REGULATION OF TP53 ACTIVITY THROUGH ASSOCIATION WITH CO-FACTORS%REACTOME%R-RNO-6804759.1 Regulation of TP53 Activity through Association with Co-factors CLEC7A (DECTIN-1) INDUCES NFAT ACTIVATION%REACTOME%R-RNO-5607763.1 CLEC7A (Dectin-1) induces NFAT activation GP1B-IX-V ACTIVATION SIGNALLING%REACTOME DATABASE ID RELEASE 66%10145640 GP1b-IX-V activation signalling CATION-COUPLED CHLORIDE COTRANSPORTERS%REACTOME DATABASE ID RELEASE 66%10145620 Cation-coupled Chloride cotransporters FGFRL1 MODULATION OF FGFR1 SIGNALING%REACTOME%R-RNO-5658623.1 FGFRL1 modulation of FGFR1 signaling APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS%REACTOME%R-RNO-111465.1 Apoptotic cleavage of cellular proteins MICRORNA (MIRNA) BIOGENESIS%REACTOME%R-RNO-203927.1 MicroRNA (miRNA) biogenesis STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES%REACTOME%R-RNO-1834941.1 STING mediated induction of host immune responses MEIOTIC RECOMBINATION%REACTOME%R-RNO-912446.1 Meiotic recombination RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF KERATINOCYTES%REACTOME DATABASE ID RELEASE 66%10146265 RUNX1 regulates transcription of genes involved in differentiation of keratinocytes MITOCHONDRIAL PROTEIN IMPORT%REACTOME DATABASE ID RELEASE 66%10146287 Mitochondrial protein import ENZYMATIC DEGRADATION OF DOPAMINE BY MONOAMINE OXIDASE%REACTOME DATABASE ID RELEASE 66%10145518 Enzymatic degradation of Dopamine by monoamine oxidase G ALPHA (Z) SIGNALLING EVENTS%REACTOME%R-RNO-418597.1 G alpha (z) signalling events SURFACTANT METABOLISM%REACTOME DATABASE ID RELEASE 66%10145605 Surfactant metabolism AUTODEGRADATION OF CDH1 BY CDH1:APC C%REACTOME DATABASE ID RELEASE 66%10145213 Autodegradation of Cdh1 by Cdh1:APC C GLYCOPROTEIN HORMONES%REACTOME DATABASE ID RELEASE 66%10145514 Glycoprotein hormones RRNA PROCESSING IN THE NUCLEUS AND CYTOSOL%REACTOME DATABASE ID RELEASE 66%10146162 rRNA processing in the nucleus and cytosol INITIATION OF NUCLEAR ENVELOPE REFORMATION%REACTOME DATABASE ID RELEASE 66%10145989 Initiation of Nuclear Envelope Reformation METABOLISM OF STEROIDS%REACTOME DATABASE ID RELEASE 66%10145088 Metabolism of steroids REGULATION OF GENE EXPRESSION IN BETA CELLS%REACTOME%R-RNO-210745.1 Regulation of gene expression in beta cells ACTIVATION OF BH3-ONLY PROTEINS%REACTOME DATABASE ID RELEASE 66%10145046 Activation of BH3-only proteins EXPRESSION AND PROCESSING OF NEUROTROPHINS%REACTOME%R-RNO-9036866.1 Expression and Processing of Neurotrophins G2 PHASE%REACTOME DATABASE ID RELEASE 66%10145274 G2 Phase CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION%REACTOME%R-RNO-109688.1 Cleavage of Growing Transcript in the Termination Region CA2+ PATHWAY%REACTOME DATABASE ID RELEASE 66%10145578 Ca2+ pathway VITAMIN E%REACTOME DATABASE ID RELEASE 66%10146249 Vitamin E INTRACELLULAR SIGNALING BY SECOND MESSENGERS%REACTOME DATABASE ID RELEASE 66%10144994 Intracellular signaling by second messengers RECEPTOR MEDIATED MITOPHAGY%REACTOME DATABASE ID RELEASE 66%10146273 Receptor Mediated Mitophagy SOS-MEDIATED SIGNALLING%REACTOME%R-RNO-112412.1 SOS-mediated signalling TCF DEPENDENT SIGNALING IN RESPONSE TO WNT%REACTOME%R-RNO-201681.1 TCF dependent signaling in response to WNT OTHER INTERLEUKIN SIGNALING%REACTOME%R-RNO-449836.1 Other interleukin signaling INTRA-GOLGI TRAFFIC%REACTOME DATABASE ID RELEASE 66%10146194 Intra-Golgi traffic GRB2 EVENTS IN ERBB2 SIGNALING%REACTOME DATABASE ID RELEASE 66%10145849 GRB2 events in ERBB2 signaling DAP12 INTERACTIONS%REACTOME%R-RNO-2172127.1 DAP12 interactions ORGANIC ANION TRANSPORT%REACTOME%R-RNO-561048.1 Organic anion transport TRYPTOPHAN CATABOLISM%REACTOME%R-RNO-71240.1 Tryptophan catabolism SYNTHESIS OF LIPOXINS (LX)%REACTOME DATABASE ID RELEASE 66%10145463 Synthesis of Lipoxins (LX) AXONAL GROWTH STIMULATION%REACTOME%R-RNO-209563.1 Axonal growth stimulation SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL%REACTOME%R-RNO-1855183.1 Synthesis of IP2, IP, and Ins in the cytosol RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 66%10144903 RNA Polymerase II Transcription Initiation And Promoter Clearance SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21%REACTOME DATABASE ID RELEASE 66%10145271 SCF(Skp2)-mediated degradation of p27 p21 GLYOXYLATE METABOLISM AND GLYCINE DEGRADATION%REACTOME%R-RNO-389661.1 Glyoxylate metabolism and glycine degradation ERYTHROPOIETIN ACTIVATES RAS%REACTOME DATABASE ID RELEASE 66%10146321 Erythropoietin activates RAS MITOCHONDRIAL UNCOUPLING PROTEINS%REACTOME DATABASE ID RELEASE 66%10145136 Mitochondrial Uncoupling Proteins INTERACTION BETWEEN L1 AND ANKYRINS%REACTOME DATABASE ID RELEASE 66%10145576 Interaction between L1 and Ankyrins REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX%REACTOME%R-RNO-204174.1 Regulation of pyruvate dehydrogenase (PDH) complex ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S%REACTOME%R-RNO-72662.1 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S SYNTHESIS OF DOLICHYL-PHOSPHATE%REACTOME DATABASE ID RELEASE 66%10145306 Synthesis of Dolichyl-phosphate KETONE BODY CATABOLISM%REACTOME%R-RNO-77108.1 Ketone body catabolism REDUCTION OF CYTOSOLIC CA++ LEVELS%REACTOME%R-RNO-418359.1 Reduction of cytosolic Ca++ levels TCR SIGNALING%REACTOME DATABASE ID RELEASE 66%10145376 TCR signaling SUMOYLATION%REACTOME%R-RNO-2990846.1 SUMOylation CALMODULIN INDUCED EVENTS%REACTOME DATABASE ID RELEASE 66%10144991 Calmodulin induced events ACTIVATION OF PKB%REACTOME DATABASE ID RELEASE 66%10144955 Activation of PKB MET ACTIVATES PTK2 SIGNALING%REACTOME DATABASE ID RELEASE 66%10146246 MET activates PTK2 signaling OPIOID SIGNALLING%REACTOME%R-RNO-111885.1 Opioid Signalling SIGNALING BY ERBB2%REACTOME%R-RNO-1227986.1 Signaling by ERBB2 PHASE 0 - RAPID DEPOLARISATION%REACTOME DATABASE ID RELEASE 66%10146067 Phase 0 - rapid depolarisation MISCELLANEOUS SUBSTRATES%REACTOME DATABASE ID RELEASE 66%10145442 Miscellaneous substrates HATS ACETYLATE HISTONES%REACTOME%R-RNO-3214847.1 HATs acetylate histones REGULATION OF IFNA SIGNALING%REACTOME%R-RNO-912694.1 Regulation of IFNA signaling ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES%REACTOME%R-RNO-1169410.1 Antiviral mechanism by IFN-stimulated genes SIGNALING BY NOTCH4%REACTOME DATABASE ID RELEASE 66%10146330 Signaling by NOTCH4 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM%REACTOME DATABASE ID RELEASE 66%10144804 Cobalamin (Cbl, vitamin B12) transport and metabolism ASSEMBLY OF ACTIVE LPL AND LIPC LIPASE COMPLEXES%REACTOME DATABASE ID RELEASE 66%10146149 Assembly of active LPL and LIPC lipase complexes SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX)%REACTOME%R-RNO-2162123.1 Synthesis of Prostaglandins (PG) and Thromboxanes (TX) INTERLEUKIN-38 SIGNALING%REACTOME DATABASE ID RELEASE 66%10146291 Interleukin-38 signaling AUF1 (HNRNP D0) BINDS AND DESTABILIZES MRNA%REACTOME DATABASE ID RELEASE 66%10145697 AUF1 (hnRNP D0) binds and destabilizes mRNA CYTOKINE SIGNALING IN IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 66%10145164 Cytokine Signaling in Immune system FORMATION OF A POOL OF FREE 40S SUBUNITS%REACTOME%R-RNO-72689.1 Formation of a pool of free 40S subunits LRR FLII-INTERACTING PROTEIN 1 (LRRFIP1) ACTIVATES TYPE I IFN PRODUCTION%REACTOME%R-RNO-3134973.1 LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production DISSOLUTION OF FIBRIN CLOT%REACTOME DATABASE ID RELEASE 66%10145082 Dissolution of Fibrin Clot RESOLUTION OF D-LOOP STRUCTURES THROUGH HOLLIDAY JUNCTION INTERMEDIATES%REACTOME%R-RNO-5693568.1 Resolution of D-loop Structures through Holliday Junction Intermediates RETINOID METABOLISM AND TRANSPORT%REACTOME DATABASE ID RELEASE 66%10145777 Retinoid metabolism and transport METABOLISM OF VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 66%10144806 Metabolism of vitamins and cofactors FIBRONECTIN MATRIX FORMATION%REACTOME%R-RNO-1566977.1 Fibronectin matrix formation RMTS METHYLATE HISTONE ARGININES%REACTOME%R-RNO-3214858.1 RMTs methylate histone arginines AMPK INHIBITS CHREBP TRANSCRIPTIONAL ACTIVATION ACTIVITY%REACTOME DATABASE ID RELEASE 66%10145123 AMPK inhibits chREBP transcriptional activation activity MAPK FAMILY SIGNALING CASCADES%REACTOME%R-RNO-5683057.1 MAPK family signaling cascades ACTIVATION OF NIMA KINASES NEK9, NEK6, NEK7%REACTOME%R-RNO-2980767.1 Activation of NIMA Kinases NEK9, NEK6, NEK7 CYSTEINE FORMATION FROM HOMOCYSTEINE%REACTOME%R-RNO-1614603.1 Cysteine formation from homocysteine NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION)%REACTOME%R-RNO-198725.1 Nuclear Events (kinase and transcription factor activation) PYRIMIDINE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 66%10144841 Pyrimidine biosynthesis ADAPTIVE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 66%10145356 Adaptive Immune System RAF-INDEPENDENT MAPK1 3 ACTIVATION%REACTOME DATABASE ID RELEASE 66%10144960 RAF-independent MAPK1 3 activation RNA POLYMERASE II TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 66%10144832 RNA Polymerase II Transcription Termination SYNTHESIS OF KETONE BODIES%REACTOME%R-RNO-77111.1 Synthesis of Ketone Bodies LACTOSE SYNTHESIS%REACTOME DATABASE ID RELEASE 66%10146097 Lactose synthesis DOWNSTREAM SIGNALING OF ACTIVATED FGFR4%REACTOME DATABASE ID RELEASE 66%10145261 Downstream signaling of activated FGFR4 VXPX CARGO-TARGETING TO CILIUM%REACTOME DATABASE ID RELEASE 66%10146083 VxPx cargo-targeting to cilium THE ROLE OF GTSE1 IN G2 M PROGRESSION AFTER G2 CHECKPOINT%REACTOME%R-RNO-8852276.1 The role of GTSE1 in G2 M progression after G2 checkpoint TWIK-RELATED SPINAL CORD K+ CHANNEL (TRESK)%REACTOME DATABASE ID RELEASE 66%10145846 TWIK-related spinal cord K+ channel (TRESK) NEUROTRANSMITTER RELEASE CYCLE%REACTOME%R-RNO-112310.1 Neurotransmitter release cycle FREE FATTY ACID RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145661 Free fatty acid receptors MAPK1 (ERK2) ACTIVATION%REACTOME DATABASE ID RELEASE 66%10144963 MAPK1 (ERK2) activation PROCESSING AND ACTIVATION OF SUMO%REACTOME%R-RNO-3215018.1 Processing and activation of SUMO RNA POLYMERASE II TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 66%10144905 RNA Polymerase II Transcription Initiation RUNX3 REGULATES WNT SIGNALING%REACTOME DATABASE ID RELEASE 66%10146277 RUNX3 regulates WNT signaling FORMATION OF EDITOSOMES BY ADAR PROTEINS%REACTOME%R-RNO-77042.1 Formation of editosomes by ADAR proteins ARACHIDONIC ACID METABOLISM%REACTOME%R-RNO-2142753.1 Arachidonic acid metabolism ION TRANSPORT BY P-TYPE ATPASES%REACTOME%R-RNO-936837.1 Ion transport by P-type ATPases PI-3K CASCADE:FGFR4%REACTOME%R-RNO-5654720.1 PI-3K cascade:FGFR4 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS%REACTOME DATABASE ID RELEASE 66%10144984 SLBP independent Processing of Histone Pre-mRNAs G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA%REACTOME%R-RNO-392451.1 G beta:gamma signalling through PI3Kgamma CLEC7A (DECTIN-1) SIGNALING%REACTOME%R-RNO-5607764.1 CLEC7A (Dectin-1) signaling CELL-EXTRACELLULAR MATRIX INTERACTIONS%REACTOME DATABASE ID RELEASE 66%10145642 Cell-extracellular matrix interactions SODIUM PROTON EXCHANGERS%REACTOME%R-RNO-425986.1 Sodium Proton exchangers INTERLEUKIN-7 SIGNALING%REACTOME%R-RNO-1266695.1 Interleukin-7 signaling ATTACHMENT OF GPI ANCHOR TO UPAR%REACTOME DATABASE ID RELEASE 66%10145107 Attachment of GPI anchor to uPAR ANTIGEN PROCESSING-CROSS PRESENTATION%REACTOME DATABASE ID RELEASE 66%10145813 Antigen processing-Cross presentation CALCITONIN-LIKE LIGAND RECEPTORS%REACTOME%R-RNO-419812.1 Calcitonin-like ligand receptors TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER%REACTOME%R-RNO-2173793.1 Transcriptional activity of SMAD2 SMAD3:SMAD4 heterotrimer P75NTR REGULATES AXONOGENESIS%REACTOME%R-RNO-193697.1 p75NTR regulates axonogenesis MET ACTIVATES PTPN11%REACTOME%R-RNO-8865999.1 MET activates PTPN11 RUNX1 AND FOXP3 CONTROL THE DEVELOPMENT OF REGULATORY T LYMPHOCYTES (TREGS)%REACTOME%R-RNO-8877330.1 RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) BILE ACID AND BILE SALT METABOLISM%REACTOME%R-RNO-194068.1 Bile acid and bile salt metabolism PREGNENOLONE BIOSYNTHESIS%REACTOME%R-RNO-196108.1 Pregnenolone biosynthesis CS DS DEGRADATION%REACTOME DATABASE ID RELEASE 66%10145885 CS DS degradation PI AND PC TRANSPORT BETWEEN ER AND GOLGI MEMBRANES%REACTOME%R-RNO-1483196.1 PI and PC transport between ER and Golgi membranes REELIN SIGNALLING PATHWAY%REACTOME DATABASE ID RELEASE 66%10146225 Reelin signalling pathway MRNA EDITING: A TO I CONVERSION%REACTOME%R-RNO-75064.1 mRNA Editing: A to I Conversion PHOSPHOLIPASE C-MEDIATED CASCADE; FGFR2%REACTOME DATABASE ID RELEASE 66%10146098 Phospholipase C-mediated cascade; FGFR2 MITOCHONDRIAL CALCIUM ION TRANSPORT%REACTOME%R-RNO-8949215.1 Mitochondrial calcium ion transport MITOCHONDRIAL ABC TRANSPORTERS%REACTOME%R-RNO-1369007.1 Mitochondrial ABC transporters TERMINATION OF TRANSLESION DNA SYNTHESIS%REACTOME DATABASE ID RELEASE 66%10146096 Termination of translesion DNA synthesis PEPTIDE HORMONE BIOSYNTHESIS%REACTOME%R-RNO-209952.1 Peptide hormone biosynthesis MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS%REACTOME%R-RNO-1362409.1 Mitochondrial iron-sulfur cluster biogenesis SEROTONIN NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 66%10145528 Serotonin Neurotransmitter Release Cycle LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATION FROM THE CENTROSOME%REACTOME%R-RNO-380284.1 Loss of proteins required for interphase microtubule organization from the centrosome LECTIN PATHWAY OF COMPLEMENT ACTIVATION%REACTOME%R-RNO-166662.1 Lectin pathway of complement activation FORMATION OF THE EARLY ELONGATION COMPLEX%REACTOME DATABASE ID RELEASE 66%10145012 Formation of the Early Elongation Complex PTK6 PROMOTES HIF1A STABILIZATION%REACTOME%R-RNO-8857538.1 PTK6 promotes HIF1A stabilization METABOLISM OF STEROID HORMONES%REACTOME DATABASE ID RELEASE 66%10145319 Metabolism of steroid hormones CHREBP ACTIVATES METABOLIC GENE EXPRESSION%REACTOME DATABASE ID RELEASE 66%10145124 ChREBP activates metabolic gene expression UREA CYCLE%REACTOME DATABASE ID RELEASE 66%10144786 Urea cycle MRNA EDITING%REACTOME%R-RNO-75072.1 mRNA Editing BETA OXIDATION OF LAUROYL-COA TO DECANOYL-COA-COA%REACTOME DATABASE ID RELEASE 66%10144931 Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA CASP8 ACTIVITY IS INHIBITED%REACTOME%R-RNO-5218900.1 CASP8 activity is inhibited PTK6 REGULATES CELL CYCLE%REACTOME DATABASE ID RELEASE 66%10146203 PTK6 Regulates Cell Cycle HYDROXYCARBOXYLIC ACID-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145664 Hydroxycarboxylic acid-binding receptors EFFECTS OF PIP2 HYDROLYSIS%REACTOME%R-RNO-114508.1 Effects of PIP2 hydrolysis UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A%REACTOME DATABASE ID RELEASE 66%10144752 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A SYNTHESIS OF PS%REACTOME%R-RNO-1483101.1 Synthesis of PS PHASE 4 - RESTING MEMBRANE POTENTIAL%REACTOME%R-RNO-5576886.1 Phase 4 - resting membrane potential NOTCH3 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME DATABASE ID RELEASE 66%10145951 NOTCH3 Activation and Transmission of Signal to the Nucleus BETA OXIDATION OF BUTANOYL-COA TO ACETYL-COA%REACTOME DATABASE ID RELEASE 66%10144935 Beta oxidation of butanoyl-CoA to acetyl-CoA UNWINDING OF DNA%REACTOME%R-RNO-176974.1 Unwinding of DNA PKB-MEDIATED EVENTS%REACTOME%R-RNO-109703.1 PKB-mediated events JOSEPHIN DOMAIN DUBS%REACTOME DATABASE ID RELEASE 66%10146138 Josephin domain DUBs HSP90 CHAPERONE CYCLE FOR SHRS%REACTOME DATABASE ID RELEASE 66%10146010 HSP90 chaperone cycle for SHRs NEUROFASCIN INTERACTIONS%REACTOME%R-RNO-447043.1 Neurofascin interactions COMPLEX I BIOGENESIS%REACTOME%R-RNO-6799198.1 Complex I biogenesis RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+%REACTOME%R-RNO-76005.1 Response to elevated platelet cytosolic Ca2+ GLUCONEOGENESIS%REACTOME%R-RNO-70263.1 Gluconeogenesis MAPK6 MAPK4 SIGNALING%REACTOME%R-RNO-5687128.1 MAPK6 MAPK4 signaling SIGNALING BY NUCLEAR RECEPTORS%REACTOME%R-RNO-9006931.1 Signaling by Nuclear Receptors ENOS ACTIVATION%REACTOME DATABASE ID RELEASE 66%10145394 eNOS activation GABA RECEPTOR ACTIVATION%REACTOME%R-RNO-977443.1 GABA receptor activation REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR%REACTOME DATABASE ID RELEASE 66%10145809 Regulation of gene expression by Hypoxia-inducible Factor STEROLS ARE 12-HYDROXYLATED BY CYP8B1%REACTOME%R-RNO-211994.1 Sterols are 12-hydroxylated by CYP8B1 WNT LIGAND BIOGENESIS AND TRAFFICKING%REACTOME%R-RNO-3238698.1 WNT ligand biogenesis and trafficking MET RECEPTOR ACTIVATION%REACTOME DATABASE ID RELEASE 66%10146172 MET Receptor Activation GPCR LIGAND BINDING%REACTOME DATABASE ID RELEASE 66%10145122 GPCR ligand binding TRIGLYCERIDE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 66%10144910 Triglyceride biosynthesis BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME%R-RNO-70895.1 Branched-chain amino acid catabolism NTRK2 ACTIVATES RAC1%REACTOME DATABASE ID RELEASE 66%10146322 NTRK2 activates RAC1 SIGNALING BY ERBB4%REACTOME%R-RNO-1236394.1 Signaling by ERBB4 DNA DAMAGE REVERSAL%REACTOME DATABASE ID RELEASE 66%10146231 DNA Damage Reversal DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX%REACTOME%R-RNO-3769402.1 Deactivation of the beta-catenin transactivating complex RECRUITMENT AND ATM-MEDIATED PHOSPHORYLATION OF REPAIR AND SIGNALING PROTEINS AT DNA DOUBLE STRAND BREAKS%REACTOME DATABASE ID RELEASE 66%10144760 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE%REACTOME%R-RNO-168179.1 Toll Like Receptor TLR1:TLR2 Cascade HEDGEHOG 'OFF' STATE%REACTOME%R-RNO-5610787.1 Hedgehog 'off' state APC-CDC20 MEDIATED DEGRADATION OF NEK2A%REACTOME DATABASE ID RELEASE 66%10145263 APC-Cdc20 mediated degradation of Nek2A NFG AND PRONGF BINDS TO P75NTR%REACTOME%R-RNO-205017.1 NFG and proNGF binds to p75NTR TRANSCRIPTIONAL ACTIVATION OF CELL CYCLE INHIBITOR P21%REACTOME DATABASE ID RELEASE 66%10146177 Transcriptional activation of cell cycle inhibitor p21 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS%REACTOME%R-RNO-416993.1 Trafficking of GluR2-containing AMPA receptors PROLINE CATABOLISM%REACTOME DATABASE ID RELEASE 66%10144794 Proline catabolism DEGRADATION OF GLI1 BY THE PROTEASOME%REACTOME DATABASE ID RELEASE 66%10146077 Degradation of GLI1 by the proteasome BETA OXIDATION OF DECANOYL-COA TO OCTANOYL-COA-COA%REACTOME%R-RNO-77346.1 Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA MMR%REACTOME%R-RNO-5358508.1 MMR POST-TRANSCRIPTIONAL SILENCING BY SMALL RNAS%REACTOME DATABASE ID RELEASE 66%10145622 Post-transcriptional silencing by small RNAs PI METABOLISM%REACTOME DATABASE ID RELEASE 66%10145378 PI Metabolism NEGATIVE REGULATION OF FGFR4 SIGNALING%REACTOME%R-RNO-5654733.1 Negative regulation of FGFR4 signaling NUCLEOBASE CATABOLISM%REACTOME%R-RNO-8956319.1 Nucleobase catabolism CROSS-PRESENTATION OF PARTICULATE EXOGENOUS ANTIGENS (PHAGOSOMES)%REACTOME%R-RNO-1236973.1 Cross-presentation of particulate exogenous antigens (phagosomes) MEIOSIS%REACTOME%R-RNO-1500620.1 Meiosis AKT-MEDIATED INACTIVATION OF FOXO1A%REACTOME DATABASE ID RELEASE 66%10145436 AKT-mediated inactivation of FOXO1A CREB PHOSPHORYLATION%REACTOME%R-RNO-199920.1 CREB phosphorylation RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN INTERLEUKIN SIGNALING%REACTOME DATABASE ID RELEASE 66%10146268 RUNX1 regulates transcription of genes involved in interleukin signaling SDK INTERACTIONS%REACTOME%R-RNO-373756.1 SDK interactions XENOBIOTICS%REACTOME DATABASE ID RELEASE 66%10144919 Xenobiotics SIGNALING PATHWAYS%REACTOME%R-RNO-162582.1 Signaling Pathways TRAF6 MEDIATED IRF7 ACTIVATION%REACTOME DATABASE ID RELEASE 66%10145758 TRAF6 mediated IRF7 activation NEUROTRANSMITTER RECEPTORS AND POSTSYNAPTIC SIGNAL TRANSMISSION%REACTOME%R-RNO-112314.1 Neurotransmitter receptors and postsynaptic signal transmission PLASMALOGEN BIOSYNTHESIS%REACTOME%R-RNO-75896.1 Plasmalogen biosynthesis TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING%REACTOME%R-RNO-975110.1 TRAF6 mediated IRF7 activation in TLR7 8 or 9 signaling ABACAVIR TRANSMEMBRANE TRANSPORT%REACTOME%R-RNO-2161517.1 Abacavir transmembrane transport RNA POLYMERASE I PROMOTER CLEARANCE%REACTOME%R-RNO-73854.1 RNA Polymerase I Promoter Clearance FCERI MEDIATED NF-KB ACTIVATION%REACTOME%R-RNO-2871837.1 FCERI mediated NF-kB activation THE AIM2 INFLAMMASOME%REACTOME%R-RNO-844615.1 The AIM2 inflammasome FORMATION OF RNA POL II ELONGATION COMPLEX%REACTOME%R-RNO-112382.1 Formation of RNA Pol II elongation complex NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%R-RNO-427413.1 NoRC negatively regulates rRNA expression FGFR3C LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 66%10145291 FGFR3c ligand binding and activation FATTY ACID METABOLISM%REACTOME%R-RNO-8978868.1 Fatty acid metabolism TNF RECEPTOR SUPERFAMILY (TNFSF) MEMBERS MEDIATING NON-CANONICAL NF-KB PATHWAY%REACTOME DATABASE ID RELEASE 66%10145372 TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway VEGFR2 MEDIATED VASCULAR PERMEABILITY%REACTOME%R-RNO-5218920.1 VEGFR2 mediated vascular permeability PI5P, PP2A AND IER3 REGULATE PI3K AKT SIGNALING%REACTOME%R-RNO-6811558.1 PI5P, PP2A and IER3 Regulate PI3K AKT Signaling FGFR1 LIGAND BINDING AND ACTIVATION%REACTOME%R-RNO-190242.1 FGFR1 ligand binding and activation SYNTHESIS OF PIPS AT THE ER MEMBRANE%REACTOME DATABASE ID RELEASE 66%10145900 Synthesis of PIPs at the ER membrane RHO GTPASES ACTIVATE IQGAPS%REACTOME DATABASE ID RELEASE 66%10146088 RHO GTPases activate IQGAPs RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 66%10145527 Recruitment of NuMA to mitotic centrosomes GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION%REACTOME%R-RNO-163841.1 Gamma carboxylation, hypusine formation and arylsulfatase activation GLYCINE DEGRADATION%REACTOME DATABASE ID RELEASE 66%10146148 Glycine degradation TANDEM PORE DOMAIN POTASSIUM CHANNELS%REACTOME DATABASE ID RELEASE 66%10145839 Tandem pore domain potassium channels DEGRADATION OF THE EXTRACELLULAR MATRIX%REACTOME%R-RNO-1474228.1 Degradation of the extracellular matrix ACYL CHAIN REMODELLING OF PG%REACTOME DATABASE ID RELEASE 66%10145863 Acyl chain remodelling of PG ACYL CHAIN REMODELING OF DAG AND TAG%REACTOME%R-RNO-1482883.1 Acyl chain remodeling of DAG and TAG NUCLEAR ENVELOPE BREAKDOWN%REACTOME DATABASE ID RELEASE 66%10145982 Nuclear Envelope Breakdown APC:CDC20 MEDIATED DEGRADATION OF CELL CYCLE PROTEINS PRIOR TO SATISFATION OF THE CELL CYCLE CHECKPOINT%REACTOME%R-RNO-179419.1 APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC%REACTOME DATABASE ID RELEASE 66%10145414 Antigen Presentation: Folding, assembly and peptide loading of class I MHC BLOCH PATHWAY%REACTOME%R-RNO-6807047.1 Bloch pathway RNA POLYMERASE I PROMOTER ESCAPE%REACTOME%R-RNO-73772.1 RNA Polymerase I Promoter Escape HDR THROUGH MMEJ (ALT-NHEJ)%REACTOME DATABASE ID RELEASE 66%10146137 HDR through MMEJ (alt-NHEJ) ALPHA-DEFENSINS%REACTOME%R-RNO-1462054.1 Alpha-defensins TOLL LIKE RECEPTOR 3 (TLR3) CASCADE%REACTOME DATABASE ID RELEASE 66%10145161 Toll Like Receptor 3 (TLR3) Cascade MET INTERACTS WITH TNS PROTEINS%REACTOME DATABASE ID RELEASE 66%10146251 MET interacts with TNS proteins INTERFERON GAMMA SIGNALING%REACTOME%R-RNO-877300.1 Interferon gamma signaling MAJOR PATHWAY OF RRNA PROCESSING IN THE NUCLEOLUS AND CYTOSOL%REACTOME%R-RNO-6791226.1 Major pathway of rRNA processing in the nucleolus and cytosol MET ACTIVATES STAT3%REACTOME%R-RNO-8875791.1 MET activates STAT3 ERYTHROCYTES TAKE UP CARBON DIOXIDE AND RELEASE OXYGEN%REACTOME DATABASE ID RELEASE 66%10145817 Erythrocytes take up carbon dioxide and release oxygen RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN BCR SIGNALING%REACTOME DATABASE ID RELEASE 66%10146269 RUNX1 regulates transcription of genes involved in BCR signaling G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%R-RNO-1296059.1 G protein gated Potassium channels CLEARANCE OF SERATONIN%REACTOME%R-RNO-380615.1 Clearance of seratonin MITOTIC PROMETAPHASE%REACTOME DATABASE ID RELEASE 66%10145506 Mitotic Prometaphase PLATELET SENSITIZATION BY LDL%REACTOME DATABASE ID RELEASE 66%10145634 Platelet sensitization by LDL REGULATION OF RUNX2 EXPRESSION AND ACTIVITY%REACTOME%R-RNO-8939902.1 Regulation of RUNX2 expression and activity RAB GERANYLGERANYLATION%REACTOME%R-RNO-8873719.1 RAB geranylgeranylation NEUROTRANSMITTER UPTAKE AND METABOLISM IN GLIAL CELLS%REACTOME%R-RNO-112313.1 Neurotransmitter uptake and metabolism In glial cells RAB GEFS EXCHANGE GTP FOR GDP ON RABS%REACTOME%R-RNO-8876198.1 RAB GEFs exchange GTP for GDP on RABs PRESYNAPTIC DEPOLARIZATION AND CALCIUM CHANNEL OPENING%REACTOME%R-RNO-112308.1 Presynaptic depolarization and calcium channel opening RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING%REACTOME DATABASE ID RELEASE 66%10144894 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening HISTIDINE CATABOLISM%REACTOME%R-RNO-70921.1 Histidine catabolism SIGNALING BY HIPPO%REACTOME DATABASE ID RELEASE 66%10145927 Signaling by Hippo RIBOSOMAL SCANNING AND START CODON RECOGNITION%REACTOME DATABASE ID RELEASE 66%10144836 Ribosomal scanning and start codon recognition PLATELET AGGREGATION (PLUG FORMATION)%REACTOME DATABASE ID RELEASE 66%10145477 Platelet Aggregation (Plug Formation) HEME BIOSYNTHESIS%REACTOME%R-RNO-189451.1 Heme biosynthesis NOD1 2 SIGNALING PATHWAY%REACTOME%R-RNO-168638.1 NOD1 2 Signaling Pathway INTERLEUKIN-4 AND INTERLEUKIN-13 SIGNALING%REACTOME%R-RNO-6785807.1 Interleukin-4 and Interleukin-13 signaling RELAXIN RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145665 Relaxin receptors ORGANIC CATION ANION ZWITTERION TRANSPORT%REACTOME%R-RNO-549132.1 Organic cation anion zwitterion transport CARNITINE SYNTHESIS%REACTOME DATABASE ID RELEASE 66%10144812 Carnitine synthesis CAM-PDE 1 ACTIVATION%REACTOME DATABASE ID RELEASE 66%10145008 Cam-PDE 1 activation HDR THROUGH SINGLE STRAND ANNEALING (SSA)%REACTOME DATABASE ID RELEASE 66%10144912 HDR through Single Strand Annealing (SSA) FASL CD95L SIGNALING%REACTOME%R-RNO-75157.1 FasL CD95L signaling SUMO IS PROTEOLYTICALLY PROCESSED%REACTOME%R-RNO-3065679.1 SUMO is proteolytically processed MAP2K AND MAPK ACTIVATION%REACTOME%R-RNO-5674135.1 MAP2K and MAPK activation ACTIVATION OF RAS IN B CELLS%REACTOME%R-RNO-1169092.1 Activation of RAS in B cells SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1%REACTOME DATABASE ID RELEASE 66%10145226 SCF-beta-TrCP mediated degradation of Emi1 ETHANOL OXIDATION%REACTOME DATABASE ID RELEASE 66%10144819 Ethanol oxidation RHO GTPASES REGULATE CFTR TRAFFICKING%REACTOME DATABASE ID RELEASE 66%10146090 RHO GTPases regulate CFTR trafficking FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF)%REACTOME DATABASE ID RELEASE 66%10146023 Formation of Senescence-Associated Heterochromatin Foci (SAHF) GOLGI-TO-ER RETROGRADE TRANSPORT%REACTOME%R-RNO-8856688.1 Golgi-to-ER retrograde transport REGULATION OF TP53 ACTIVITY THROUGH METHYLATION%REACTOME DATABASE ID RELEASE 66%10146002 Regulation of TP53 Activity through Methylation RESPIRATORY ELECTRON TRANSPORT%REACTOME%R-RNO-611105.1 Respiratory electron transport REVERSIBLE HYDRATION OF CARBON DIOXIDE%REACTOME%R-RNO-1475029.1 Reversible hydration of carbon dioxide SENSING OF DNA DOUBLE STRAND BREAKS%REACTOME%R-RNO-5693548.1 Sensing of DNA Double Strand Breaks NOSIP MEDIATED ENOS TRAFFICKING%REACTOME DATABASE ID RELEASE 66%10145408 NOSIP mediated eNOS trafficking BIOSYNTHESIS OF PROTECTIN AND RESOLVIN CONJUGATES IN TISSUE REGENERATION (PCTR AND RCTR)%REACTOME%R-RNO-9026766.1 Biosynthesis of protectin and resolvin conjugates in tissue regeneration (PCTR and RCTR) COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES%REACTOME%R-RNO-1650814.1 Collagen biosynthesis and modifying enzymes CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6%REACTOME%R-RNO-69017.1 CDK-mediated phosphorylation and removal of Cdc6 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24-HYDROXYCHOLESTEROL%REACTOME%R-RNO-193775.1 Synthesis of bile acids and bile salts via 24-hydroxycholesterol RUNX3 REGULATES CDKN1A TRANSCRIPTION%REACTOME%R-RNO-8941855.1 RUNX3 regulates CDKN1A transcription INTERLEUKIN-6 FAMILY SIGNALING%REACTOME%R-RNO-6783589.1 Interleukin-6 family signaling NA+ CL- DEPENDENT NEUROTRANSMITTER TRANSPORTERS%REACTOME%R-RNO-442660.1 Na+ Cl- dependent neurotransmitter transporters REGULATION OF MITOTIC CELL CYCLE%REACTOME%R-RNO-453276.1 Regulation of mitotic cell cycle ERKS ARE INACTIVATED%REACTOME DATABASE ID RELEASE 66%10145380 ERKs are inactivated PRE-NOTCH TRANSCRIPTION AND TRANSLATION%REACTOME DATABASE ID RELEASE 66%10146305 Pre-NOTCH Transcription and Translation VITAMIN B2 (RIBOFLAVIN) METABOLISM%REACTOME DATABASE ID RELEASE 66%10145350 Vitamin B2 (riboflavin) metabolism STABILIZATION OF P53%REACTOME%R-RNO-69541.1 Stabilization of p53 RESPONSE TO METAL IONS%REACTOME DATABASE ID RELEASE 66%10146118 Response to metal ions HYALURONAN METABOLISM%REACTOME%R-RNO-2142845.1 Hyaluronan metabolism ACTIVATION OF NA-PERMEABLE KAINATE RECEPTORS%REACTOME%R-RNO-451307.1 Activation of Na-permeable kainate receptors ELEVATION OF CYTOSOLIC CA2+ LEVELS%REACTOME%R-RNO-139853.1 Elevation of cytosolic Ca2+ levels TRANSLESION SYNTHESIS BY POLI%REACTOME DATABASE ID RELEASE 66%10146112 Translesion synthesis by POLI CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES)%REACTOME DATABASE ID RELEASE 66%10145812 Cross-presentation of soluble exogenous antigens (endosomes) GALACTOSE CATABOLISM%REACTOME DATABASE ID RELEASE 66%10144777 Galactose catabolism ERK MAPK TARGETS%REACTOME DATABASE ID RELEASE 66%10145363 ERK MAPK targets TRANSPORT OF GAMMA-CARBOXYLATED PROTEIN PRECURSORS FROM THE ENDOPLASMIC RETICULUM TO THE GOLGI APPARATUS%REACTOME%R-RNO-159763.1 Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus FORMATION OF TC-NER PRE-INCISION COMPLEX%REACTOME DATABASE ID RELEASE 66%10146151 Formation of TC-NER Pre-Incision Complex EICOSANOIDS%REACTOME%R-RNO-211979.1 Eicosanoids MRNA CAPPING%REACTOME DATABASE ID RELEASE 66%10144929 mRNA Capping MITOTIC SPINDLE CHECKPOINT%REACTOME DATABASE ID RELEASE 66%10145064 Mitotic Spindle Checkpoint SYNTHESIS OF HEPOXILINS (HX) AND TRIOXILINS (TRX)%REACTOME%R-RNO-2142696.1 Synthesis of Hepoxilins (HX) and Trioxilins (TrX) P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME%R-RNO-69613.1 p53-Independent G1 S DNA damage checkpoint SHC1 EVENTS IN ERBB2 SIGNALING%REACTOME DATABASE ID RELEASE 66%10145824 SHC1 events in ERBB2 signaling ACTIVATION OF MATRIX METALLOPROTEINASES%REACTOME%R-RNO-1592389.1 Activation of Matrix Metalloproteinases TANDEM OF PORE DOMAIN IN A WEAK INWARDLY RECTIFYING K+ CHANNELS (TWIK)%REACTOME DATABASE ID RELEASE 66%10145844 Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK) FRUCTOSE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 66%10146095 Fructose biosynthesis TRANSLOCATION OF ZAP-70 TO IMMUNOLOGICAL SYNAPSE%REACTOME DATABASE ID RELEASE 66%10145399 Translocation of ZAP-70 to Immunological synapse BIOSYNTHESIS OF DPAN-3-DERIVED PROTECTINS AND RESOLVINS%REACTOME%R-RNO-9026286.1 Biosynthesis of DPAn-3-derived protectins and resolvins REGULATION OF APOPTOSIS%REACTOME DATABASE ID RELEASE 66%10146243 Regulation of Apoptosis SYNTHESIS OF (16-20)-HYDROXYEICOSATETRAENOIC ACIDS (HETE)%REACTOME%R-RNO-2142816.1 Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) KERATAN SULFATE KERATIN METABOLISM%REACTOME DATABASE ID RELEASE 66%10145729 Keratan sulfate keratin metabolism CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A%REACTOME DATABASE ID RELEASE 66%10145216 Cdc20:Phospho-APC C mediated degradation of Cyclin A LDL CLEARANCE%REACTOME%R-RNO-8964038.1 LDL clearance TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX%REACTOME%R-RNO-445989.1 TAK1 activates NFkB by phosphorylation and activation of IKKs complex CHEMOKINE RECEPTORS BIND CHEMOKINES%REACTOME%R-RNO-380108.1 Chemokine receptors bind chemokines AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL%REACTOME%R-RNO-198323.1 AKT phosphorylates targets in the cytosol PROCESSING OF DNA DOUBLE-STRAND BREAK ENDS%REACTOME DATABASE ID RELEASE 66%10146130 Processing of DNA double-strand break ends CARGO TRAFFICKING TO THE PERICILIARY MEMBRANE%REACTOME DATABASE ID RELEASE 66%10146079 Cargo trafficking to the periciliary membrane GLYCEROPHOSPHOLIPID BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 66%10144908 Glycerophospholipid biosynthesis NEUROPHILIN INTERACTIONS WITH VEGF AND VEGFR%REACTOME%R-RNO-194306.1 Neurophilin interactions with VEGF and VEGFR DNA REPLICATION PRE-INITIATION%REACTOME DATABASE ID RELEASE 66%10144714 DNA Replication Pre-Initiation PRESYNAPTIC FUNCTION OF KAINATE RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145706 Presynaptic function of Kainate receptors NADPH REGENERATION%REACTOME DATABASE ID RELEASE 66%10145547 NADPH regeneration KERATAN SULFATE DEGRADATION%REACTOME%R-RNO-2022857.1 Keratan sulfate degradation BIOSYNTHESIS OF D-SERIES RESOLVINS%REACTOME DATABASE ID RELEASE 66%10146303 Biosynthesis of D-series resolvins AMPLIFICATION OF SIGNAL FROM THE KINETOCHORES%REACTOME%R-RNO-141424.1 Amplification of signal from the kinetochores REGULATION OF INSULIN SECRETION%REACTOME DATABASE ID RELEASE 66%10145114 Regulation of insulin secretion INTERLEUKIN-23 SIGNALING%REACTOME%R-RNO-9020933.1 Interleukin-23 signaling CALCINEURIN ACTIVATES NFAT%REACTOME DATABASE ID RELEASE 66%10145926 Calcineurin activates NFAT RNA POLYMERASE I TRANSCRIPTION%REACTOME%R-RNO-73864.1 RNA Polymerase I Transcription SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS%REACTOME%R-RNO-75876.1 Synthesis of very long-chain fatty acyl-CoAs REGULATION OF COMPLEMENT CASCADE%REACTOME%R-RNO-977606.1 Regulation of Complement cascade MTORC1-MEDIATED SIGNALLING%REACTOME%R-RNO-166208.1 mTORC1-mediated signalling METABOLISM OF POLYAMINES%REACTOME%R-RNO-351202.1 Metabolism of polyamines G2 M CHECKPOINTS%REACTOME DATABASE ID RELEASE 66%10144759 G2 M Checkpoints ORGANIC CATION TRANSPORT%REACTOME%R-RNO-549127.1 Organic cation transport TRANSCRIPTIONAL ACTIVATION OF P53 RESPONSIVE GENES%REACTOME DATABASE ID RELEASE 66%10146178 Transcriptional activation of p53 responsive genes CREATION OF C4 AND C2 ACTIVATORS%REACTOME DATABASE ID RELEASE 66%10145209 Creation of C4 and C2 activators GLUCOSE METABOLISM%REACTOME%R-RNO-70326.1 Glucose metabolism INTERLEUKIN-27 SIGNALING%REACTOME%R-RNO-9020956.1 Interleukin-27 signaling TRANSCRIPTIONAL REGULATION BY THE AP-2 (TFAP2) FAMILY OF TRANSCRIPTION FACTORS%REACTOME%R-RNO-8864260.1 Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION)%REACTOME%R-RNO-2173791.1 TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) NEGATIVE REGULATION OF TCF-DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS%REACTOME DATABASE ID RELEASE 66%10146021 Negative regulation of TCF-dependent signaling by WNT ligand antagonists BETA OXIDATION OF OCTANOYL-COA TO HEXANOYL-COA%REACTOME DATABASE ID RELEASE 66%10144937 Beta oxidation of octanoyl-CoA to hexanoyl-CoA RAB REGULATION OF TRAFFICKING%REACTOME DATABASE ID RELEASE 66%10146223 Rab regulation of trafficking NEUREXINS AND NEUROLIGINS%REACTOME%R-RNO-6794361.1 Neurexins and neuroligins FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS%REACTOME%R-RNO-2029480.1 Fcgamma receptor (FCGR) dependent phagocytosis ENDOGENOUS STEROLS%REACTOME DATABASE ID RELEASE 66%10145314 Endogenous sterols SPRY REGULATION OF FGF SIGNALING%REACTOME DATABASE ID RELEASE 66%10145760 Spry regulation of FGF signaling ER-PHAGOSOME PATHWAY%REACTOME DATABASE ID RELEASE 66%10145816 ER-Phagosome pathway OTHER SEMAPHORIN INTERACTIONS%REACTOME%R-RNO-416700.1 Other semaphorin interactions SIGNALING BY BMP%REACTOME DATABASE ID RELEASE 66%10145385 Signaling by BMP NEGATIVE REGULATION OF FGFR2 SIGNALING%REACTOME DATABASE ID RELEASE 66%10145762 Negative regulation of FGFR2 signaling REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF)%REACTOME DATABASE ID RELEASE 66%10145896 Regulation of cholesterol biosynthesis by SREBP (SREBF) APOPTOSIS%REACTOME DATABASE ID RELEASE 66%10144862 Apoptosis DERMATAN SULFATE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 66%10145924 Dermatan sulfate biosynthesis CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION%REACTOME DATABASE ID RELEASE 66%10144735 Cyclin E associated events during G1 S transition BIOGENIC AMINES ARE OXIDATIVELY DEAMINATED TO ALDEHYDES BY MAOA AND MAOB%REACTOME DATABASE ID RELEASE 66%10145055 Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB TNF SIGNALING%REACTOME%R-RNO-75893.1 TNF signaling DIGESTION OF DIETARY CARBOHYDRATE%REACTOME%R-RNO-189085.1 Digestion of dietary carbohydrate PLATELET DEGRANULATION%REACTOME DATABASE ID RELEASE 66%10145469 Platelet degranulation PROGRAMMED CELL DEATH%REACTOME%R-RNO-5357801.1 Programmed Cell Death SIGNALING BY NOTCH2%REACTOME DATABASE ID RELEASE 66%10145921 Signaling by NOTCH2 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS)%REACTOME DATABASE ID RELEASE 66%10145487 Class A 1 (Rhodopsin-like receptors) TELOMERE C-STRAND SYNTHESIS INITIATION%REACTOME DATABASE ID RELEASE 66%10145233 Telomere C-strand synthesis initiation DCC MEDIATED ATTRACTIVE SIGNALING%REACTOME%R-RNO-418885.1 DCC mediated attractive signaling THE FATTY ACID CYCLING MODEL%REACTOME DATABASE ID RELEASE 66%10145135 The fatty acid cycling model SYNTHESIS OF UDP-N-ACETYL-GLUCOSAMINE%REACTOME%R-RNO-446210.1 Synthesis of UDP-N-acetyl-glucosamine HYALURONAN BIOSYNTHESIS AND EXPORT%REACTOME%R-RNO-2142850.1 Hyaluronan biosynthesis and export SMOOTH MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 66%10145669 Smooth Muscle Contraction DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX%REACTOME%R-RNO-195253.1 Degradation of beta-catenin by the destruction complex POLO-LIKE KINASE MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 66%10145073 Polo-like kinase mediated events SYNTHESIS OF 12-EICOSATETRAENOIC ACID DERIVATIVES%REACTOME DATABASE ID RELEASE 66%10145948 Synthesis of 12-eicosatetraenoic acid derivatives BETAKLOTHO-MEDIATED LIGAND BINDING%REACTOME%R-RNO-1307965.1 betaKlotho-mediated ligand binding CYCLIN D ASSOCIATED EVENTS IN G1%REACTOME DATABASE ID RELEASE 66%10144736 Cyclin D associated events in G1 DNA DOUBLE-STRAND BREAK REPAIR%REACTOME DATABASE ID RELEASE 66%10144762 DNA Double-Strand Break Repair NICOTINATE METABOLISM%REACTOME%R-RNO-196807.1 Nicotinate metabolism ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS%REACTOME DATABASE ID RELEASE 66%10145788 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION)%REACTOME%R-RNO-70614.1 Amino acid synthesis and interconversion (transamination) TRANSPORT OF ORGANIC ANIONS%REACTOME DATABASE ID RELEASE 66%10145337 Transport of organic anions NIK-->NONCANONICAL NF-KB SIGNALING%REACTOME DATABASE ID RELEASE 66%10146074 NIK-->noncanonical NF-kB signaling HISTAMINE RECEPTORS%REACTOME%R-RNO-390650.1 Histamine receptors SHC-MEDIATED CASCADE:FGFR4%REACTOME%R-RNO-5654719.1 SHC-mediated cascade:FGFR4 APEX1-INDEPENDENT RESOLUTION OF AP SITES VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 66%10146092 APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway UNFOLDED PROTEIN RESPONSE (UPR)%REACTOME DATABASE ID RELEASE 66%10145530 Unfolded Protein Response (UPR) STIMULI-SENSING CHANNELS%REACTOME%R-RNO-2672351.1 Stimuli-sensing channels GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS)%REACTOME DATABASE ID RELEASE 66%10144780 Glycogen breakdown (glycogenolysis) B CELL ACTIVATION%REACTOME DATABASE ID RELEASE 66%10145789 B Cell Activation PTK6 REGULATES RHO GTPASES, RAS GTPASE AND MAP KINASES%REACTOME DATABASE ID RELEASE 66%10146205 PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases EPH-EPHRIN SIGNALING%REACTOME DATABASE ID RELEASE 66%10146025 EPH-Ephrin signaling TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN CYTOCHROME C RELEASE%REACTOME%R-RNO-6803204.1 TP53 Regulates Transcription of Genes Involved in Cytochrome C Release POLYMERASE SWITCHING%REACTOME DATABASE ID RELEASE 66%10144729 Polymerase switching PERK REGULATES GENE EXPRESSION%REACTOME DATABASE ID RELEASE 66%10145531 PERK regulates gene expression REGULATION OF RUNX3 EXPRESSION AND ACTIVITY%REACTOME%R-RNO-8941858.1 Regulation of RUNX3 expression and activity LIGAND-RECEPTOR INTERACTIONS%REACTOME DATABASE ID RELEASE 66%10145666 Ligand-receptor interactions PLATELET HOMEOSTASIS%REACTOME DATABASE ID RELEASE 66%10145040 Platelet homeostasis CLASSICAL ANTIBODY-MEDIATED COMPLEMENT ACTIVATION%REACTOME%R-RNO-173623.1 Classical antibody-mediated complement activation ZINC TRANSPORTERS%REACTOME DATABASE ID RELEASE 66%10145654 Zinc transporters TRANSCRIPTIONAL REGULATION BY SMALL RNAS%REACTOME DATABASE ID RELEASE 66%10146071 Transcriptional regulation by small RNAs INTERFERON SIGNALING%REACTOME%R-RNO-913531.1 Interferon Signaling IRS ACTIVATION%REACTOME DATABASE ID RELEASE 66%10144874 IRS activation BUTYROPHILIN (BTN) FAMILY INTERACTIONS%REACTOME%R-RNO-8851680.1 Butyrophilin (BTN) family interactions NUCLEOTIDE SALVAGE%REACTOME%R-RNO-8956321.1 Nucleotide salvage COENZYME A BIOSYNTHESIS%REACTOME%R-RNO-196783.1 Coenzyme A biosynthesis TRANSLESION SYNTHESIS BY POLK%REACTOME DATABASE ID RELEASE 66%10146111 Translesion synthesis by POLK KERATINIZATION%REACTOME%R-RNO-6805567.1 Keratinization MRNA 3'-END PROCESSING%REACTOME DATABASE ID RELEASE 66%10144830 mRNA 3'-end processing MITOCHONDRIAL BIOGENESIS%REACTOME DATABASE ID RELEASE 66%10145879 Mitochondrial biogenesis RIP-MEDIATED NFKB ACTIVATION VIA ZBP1%REACTOME%R-RNO-1810476.1 RIP-mediated NFkB activation via ZBP1 TWIK-RELEATED ACID-SENSITIVE K+ CHANNEL (TASK)%REACTOME DATABASE ID RELEASE 66%10145845 TWIK-releated acid-sensitive K+ channel (TASK) FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX%REACTOME DATABASE ID RELEASE 66%10144838 Formation of the ternary complex, and subsequently, the 43S complex GLYCOGEN SYNTHESIS%REACTOME%R-RNO-3322077.1 Glycogen synthesis IRAK1 RECRUITS IKK COMPLEX%REACTOME DATABASE ID RELEASE 66%10145768 IRAK1 recruits IKK complex G2 M DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 66%10144758 G2 M DNA damage checkpoint SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%R-RNO-427359.1 SIRT1 negatively regulates rRNA expression CONDENSATION OF PROMETAPHASE CHROMOSOMES%REACTOME DATABASE ID RELEASE 66%10145973 Condensation of Prometaphase Chromosomes NEGATIVE REGULATION OF FGFR3 SIGNALING%REACTOME%R-RNO-5654732.1 Negative regulation of FGFR3 signaling NEDDYLATION%REACTOME DATABASE ID RELEASE 66%10146142 Neddylation ORGANELLE BIOGENESIS AND MAINTENANCE%REACTOME DATABASE ID RELEASE 66%10145880 Organelle biogenesis and maintenance P53-INDEPENDENT DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 66%10144753 p53-Independent DNA Damage Response TFAP2 (AP-2) FAMILY REGULATES TRANSCRIPTION OF CELL CYCLE FACTORS%REACTOME%R-RNO-8866911.1 TFAP2 (AP-2) family regulates transcription of cell cycle factors REGULATION OF IFNG SIGNALING%REACTOME DATABASE ID RELEASE 66%10145739 Regulation of IFNG signaling FGFR1C LIGAND BINDING AND ACTIVATION%REACTOME%R-RNO-190373.1 FGFR1c ligand binding and activation REGULATION OF RAS BY GAPS%REACTOME%R-RNO-5658442.1 Regulation of RAS by GAPs RETROGRADE TRANSPORT AT THE TRANS-GOLGI-NETWORK%REACTOME%R-RNO-6811440.1 Retrograde transport at the Trans-Golgi-Network TRANSLOCATION OF SLC2A4 (GLUT4) TO THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 66%10145854 Translocation of SLC2A4 (GLUT4) to the plasma membrane ACTIVATION OF NMDA RECEPTORS AND POSTSYNAPTIC EVENTS%REACTOME%R-RNO-442755.1 Activation of NMDA receptors and postsynaptic events INTERACTION WITH CUMULUS CELLS%REACTOME DATABASE ID RELEASE 66%10145974 Interaction With Cumulus Cells INTERLEUKIN-9 SIGNALING%REACTOME%R-RNO-8985947.1 Interleukin-9 signaling SIGNALING BY NOTCH%REACTOME DATABASE ID RELEASE 66%10145914 Signaling by NOTCH SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE%REACTOME DATABASE ID RELEASE 66%10144727 Switching of origins to a post-replicative state SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA-HYDROXYCHOLESTEROL%REACTOME DATABASE ID RELEASE 66%10145313 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 66%10145498 Semaphorin interactions CREATINE METABOLISM%REACTOME DATABASE ID RELEASE 66%10144813 Creatine metabolism PHOSPHORYLATION OF PROTEINS INVOLVED IN G1 S TRANSITION BY ACTIVE CYCLIN E:CDK2 COMPLEXES%REACTOME DATABASE ID RELEASE 66%10145275 Phosphorylation of proteins involved in G1 S transition by active Cyclin E:Cdk2 complexes INTRINSIC PATHWAY OF FIBRIN CLOT FORMATION%REACTOME DATABASE ID RELEASE 66%10145080 Intrinsic Pathway of Fibrin Clot Formation RUNX1 INTERACTS WITH CO-FACTORS WHOSE PRECISE EFFECT ON RUNX1 TARGETS IS NOT KNOWN%REACTOME%R-RNO-8939243.1 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known SUMO IS TRANSFERRED FROM E1 TO E2 (UBE2I, UBC9)%REACTOME DATABASE ID RELEASE 66%10145988 SUMO is transferred from E1 to E2 (UBE2I, UBC9) VITAMIN D (CALCIFEROL) METABOLISM%REACTOME%R-RNO-196791.1 Vitamin D (calciferol) metabolism ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM%REACTOME%R-RNO-2046104.1 alpha-linolenic (omega3) and linoleic (omega6) acid metabolism KERATAN SULFATE BIOSYNTHESIS%REACTOME%R-RNO-2022854.1 Keratan sulfate biosynthesis ACTIVATION OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 66%10144723 Activation of the pre-replicative complex HCN CHANNELS%REACTOME%R-RNO-1296061.1 HCN channels SUMOYLATION OF DNA REPLICATION PROTEINS%REACTOME%R-RNO-4615885.1 SUMOylation of DNA replication proteins HEDGEHOG 'ON' STATE%REACTOME%R-RNO-5632684.1 Hedgehog 'on' state FRS2-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 66%10145200 Frs2-mediated activation G BETA:GAMMA SIGNALLING THROUGH PLC BETA%REACTOME DATABASE ID RELEASE 66%10145577 G beta:gamma signalling through PLC beta INHIBITION OF TSC COMPLEX FORMATION BY PKB%REACTOME%R-RNO-165181.1 Inhibition of TSC complex formation by PKB NEGATIVE REGULATION OF FGFR1 SIGNALING%REACTOME%R-RNO-5654726.1 Negative regulation of FGFR1 signaling PLASMA LIPOPROTEIN REMODELING%REACTOME%R-RNO-8963899.1 Plasma lipoprotein remodeling AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE%REACTOME%R-RNO-352230.1 Amino acid transport across the plasma membrane APOPTOSIS INDUCED DNA FRAGMENTATION%REACTOME DATABASE ID RELEASE 66%10145440 Apoptosis induced DNA fragmentation NF-KB IS ACTIVATED AND SIGNALS SURVIVAL%REACTOME%R-RNO-209560.1 NF-kB is activated and signals survival CELLULAR RESPONSE TO HEAT STRESS%REACTOME%R-RNO-3371556.1 Cellular response to heat stress TRANSPORT OF NUCLEOTIDE SUGARS%REACTOME%R-RNO-727802.1 Transport of nucleotide sugars SEPARATION OF SISTER CHROMATIDS%REACTOME DATABASE ID RELEASE 66%10145223 Separation of Sister Chromatids GAMMA-CARBOXYLATION OF PROTEIN PRECURSORS%REACTOME%R-RNO-159740.1 Gamma-carboxylation of protein precursors REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND%REACTOME DATABASE ID RELEASE 66%10145237 Removal of the Flap Intermediate from the C-strand SMAC-MEDIATED APOPTOTIC RESPONSE%REACTOME DATABASE ID RELEASE 66%10145021 SMAC-mediated apoptotic response PI-3K CASCADE:FGFR1%REACTOME%R-RNO-5654689.1 PI-3K cascade:FGFR1 METABOLISM OF COFACTORS%REACTOME DATABASE ID RELEASE 66%10145548 Metabolism of cofactors EUKARYOTIC TRANSLATION ELONGATION%REACTOME%R-RNO-156842.1 Eukaryotic Translation Elongation TELOMERE EXTENSION BY TELOMERASE%REACTOME DATABASE ID RELEASE 66%10145110 Telomere Extension By Telomerase SIGNALLING TO ERKS%REACTOME DATABASE ID RELEASE 66%10145182 Signalling to ERKs LAGGING STRAND SYNTHESIS%REACTOME%R-RNO-69186.1 Lagging Strand Synthesis POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS%REACTOME DATABASE ID RELEASE 66%10145102 Post-translational modification: synthesis of GPI-anchored proteins DIGESTION OF DIETARY LIPID%REACTOME%R-RNO-192456.1 Digestion of dietary lipid WNT5A-DEPENDENT INTERNALIZATION OF FZD4%REACTOME DATABASE ID RELEASE 66%10146042 WNT5A-dependent internalization of FZD4 COMMON PATHWAY OF FIBRIN CLOT FORMATION%REACTOME%R-RNO-140875.1 Common Pathway of Fibrin Clot Formation ACYL CHAIN REMODELLING OF PS%REACTOME DATABASE ID RELEASE 66%10145868 Acyl chain remodelling of PS ASSEMBLY OF THE ORC COMPLEX AT THE ORIGIN OF REPLICATION%REACTOME DATABASE ID RELEASE 66%10144712 Assembly of the ORC complex at the origin of replication HSF1 ACTIVATION%REACTOME%R-RNO-3371511.1 HSF1 activation NON-CODING RNA METABOLISM%REACTOME%R-RNO-194441.1 Non-coding RNA Metabolism REGULATION OF TP53 ACTIVITY THROUGH PHOSPHORYLATION%REACTOME DATABASE ID RELEASE 66%10144756 Regulation of TP53 Activity through Phosphorylation MITOCHONDRIAL TRANSLATION TERMINATION%REACTOME DATABASE ID RELEASE 66%10146065 Mitochondrial translation termination CONJUGATION OF CARBOXYLIC ACIDS%REACTOME DATABASE ID RELEASE 66%10145090 Conjugation of carboxylic acids OPSINS%REACTOME%R-RNO-419771.1 Opsins TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES%REACTOME DATABASE ID RELEASE 66%10144951 Transport of vitamins, nucleosides, and related molecules EICOSANOID LIGAND-BINDING RECEPTORS%REACTOME%R-RNO-391903.1 Eicosanoid ligand-binding receptors FRUCTOSE METABOLISM%REACTOME%R-RNO-5652084.1 Fructose metabolism B-WICH COMPLEX POSITIVELY REGULATES RRNA EXPRESSION%REACTOME DATABASE ID RELEASE 66%10146051 B-WICH complex positively regulates rRNA expression PCNA-DEPENDENT LONG PATCH BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 66%10144982 PCNA-Dependent Long Patch Base Excision Repair TNFS BIND THEIR PHYSIOLOGICAL RECEPTORS%REACTOME DATABASE ID RELEASE 66%10146122 TNFs bind their physiological receptors INTERLEUKIN-37 SIGNALING%REACTOME DATABASE ID RELEASE 66%10146292 Interleukin-37 signaling RETROGRADE NEUROTROPHIN SIGNALLING%REACTOME%R-RNO-177504.1 Retrograde neurotrophin signalling PRPP BIOSYNTHESIS%REACTOME%R-RNO-73843.1 PRPP biosynthesis RHO GTPASES ACTIVATE KTN1%REACTOME%R-RNO-5625970.1 RHO GTPases activate KTN1 PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS%REACTOME%R-RNO-202427.1 Phosphorylation of CD3 and TCR zeta chains ACTIVATION OF GABAB RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145188 Activation of GABAB receptors CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS%REACTOME%R-RNO-442742.1 CREB phosphorylation through the activation of Ras ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 66%10145158 Activation of the AP-1 family of transcription factors SYNTHESIS OF DOLICHYL-PHOSPHATE-GLUCOSE%REACTOME DATABASE ID RELEASE 66%10145673 Synthesis of dolichyl-phosphate-glucose PTK6 REGULATES RTKS AND THEIR EFFECTORS AKT1 AND DOK1%REACTOME DATABASE ID RELEASE 66%10146206 PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 COHESIN LOADING ONTO CHROMATIN%REACTOME%R-RNO-2470946.1 Cohesin Loading onto Chromatin SEMA3A PAK DEPENDENT AXON REPULSION%REACTOME DATABASE ID RELEASE 66%10145582 Sema3A PAK dependent Axon repulsion ATTENUATION PHASE%REACTOME DATABASE ID RELEASE 66%10146014 Attenuation phase RNA POLYMERASE II TRANSCRIPTION%REACTOME DATABASE ID RELEASE 66%10144750 RNA Polymerase II Transcription ROLE OF ABL IN ROBO-SLIT SIGNALING%REACTOME%R-RNO-428890.1 Role of ABL in ROBO-SLIT signaling SIGNALING BY FGFR3%REACTOME DATABASE ID RELEASE 66%10145259 Signaling by FGFR3 COLLAGEN FORMATION%REACTOME%R-RNO-1474290.1 Collagen formation DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION%REACTOME%R-RNO-3134963.1 DEx H-box helicases activate type I IFN and inflammatory cytokines production SUMOYLATION OF SUMOYLATION PROTEINS%REACTOME DATABASE ID RELEASE 66%10146029 SUMOylation of SUMOylation proteins REGULATED NECROSIS%REACTOME%R-RNO-5218859.1 Regulated Necrosis SYNTHESIS OF 15-EICOSATETRAENOIC ACID DERIVATIVES%REACTOME DATABASE ID RELEASE 66%10145944 Synthesis of 15-eicosatetraenoic acid derivatives EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA%REACTOME%R-RNO-212718.1 EGFR interacts with phospholipase C-gamma PHOSPHORYLATION OF EMI1%REACTOME DATABASE ID RELEASE 66%10145225 Phosphorylation of Emi1 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY%REACTOME%R-RNO-3301854.1 Nuclear Pore Complex (NPC) Disassembly REPRESSION OF WNT TARGET GENES%REACTOME DATABASE ID RELEASE 66%10146038 Repression of WNT target genes APOPTOTIC EXECUTION PHASE%REACTOME DATABASE ID RELEASE 66%10145388 Apoptotic execution phase RUNX3 REGULATES NOTCH SIGNALING%REACTOME%R-RNO-8941856.1 RUNX3 regulates NOTCH signaling VEGFR2 MEDIATED CELL PROLIFERATION%REACTOME DATABASE ID RELEASE 66%10146032 VEGFR2 mediated cell proliferation NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145596 Nucleotide-like (purinergic) receptors SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 27-HYDROXYCHOLESTEROL%REACTOME%R-RNO-193807.1 Synthesis of bile acids and bile salts via 27-hydroxycholesterol INTEGRIN SIGNALING%REACTOME DATABASE ID RELEASE 66%10145478 Integrin signaling G ALPHA (I) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 66%10144868 G alpha (i) signalling events TRANSMISSION ACROSS CHEMICAL SYNAPSES%REACTOME%R-RNO-112315.1 Transmission across Chemical Synapses FGFR2 LIGAND BINDING AND ACTIVATION%REACTOME%R-RNO-190241.1 FGFR2 ligand binding and activation SIGNALING BY NON-RECEPTOR TYROSINE KINASES%REACTOME DATABASE ID RELEASE 66%10146199 Signaling by Non-Receptor Tyrosine Kinases CARDIAC CONDUCTION%REACTOME%R-RNO-5576891.1 Cardiac conduction TBC RABGAPS%REACTOME DATABASE ID RELEASE 66%10146222 TBC RABGAPs FBXL7 DOWN-REGULATES AURKA DURING MITOTIC ENTRY AND IN EARLY MITOSIS%REACTOME%R-RNO-8854050.1 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis COPI-INDEPENDENT GOLGI-TO-ER RETROGRADE TRAFFIC%REACTOME%R-RNO-6811436.1 COPI-independent Golgi-to-ER retrograde traffic TANDEM PORE DOMAIN HALOTHANE-INHIBITED K+ CHANNEL (THIK)%REACTOME DATABASE ID RELEASE 66%10145843 Tandem pore domain halothane-inhibited K+ channel (THIK) PYROPHOSPHATE HYDROLYSIS%REACTOME%R-RNO-71737.1 Pyrophosphate hydrolysis MITOPHAGY%REACTOME DATABASE ID RELEASE 66%10146046 Mitophagy LYSOSOMAL OLIGOSACCHARIDE CATABOLISM%REACTOME DATABASE ID RELEASE 66%10146170 Lysosomal oligosaccharide catabolism POTASSIUM CHANNELS%REACTOME%R-RNO-1296071.1 Potassium Channels PI3K CASCADE%REACTOME DATABASE ID RELEASE 66%10144954 PI3K Cascade BREAKDOWN OF THE NUCLEAR LAMINA%REACTOME%R-RNO-352238.1 Breakdown of the nuclear lamina ACTIVATION, TRANSLOCATION AND OLIGOMERIZATION OF BAX%REACTOME DATABASE ID RELEASE 66%10145017 Activation, translocation and oligomerization of BAX ENDOSOMAL VACUOLAR PATHWAY%REACTOME%R-RNO-1236977.1 Endosomal Vacuolar pathway ABACAVIR METABOLISM%REACTOME%R-RNO-2161541.1 Abacavir metabolism PROTEIN FOLDING%REACTOME%R-RNO-391251.1 Protein folding ACTIVATION OF BIM AND TRANSLOCATION TO MITOCHONDRIA%REACTOME DATABASE ID RELEASE 66%10145048 Activation of BIM and translocation to mitochondria SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION%REACTOME%R-RNO-399955.1 SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion SIGNALING BY NTRKS%REACTOME%R-RNO-166520.1 Signaling by NTRKs HUR (ELAVL1) BINDS AND STABILIZES MRNA%REACTOME DATABASE ID RELEASE 66%10145693 HuR (ELAVL1) binds and stabilizes mRNA INTESTINAL LIPID ABSORPTION%REACTOME DATABASE ID RELEASE 66%10145460 Intestinal lipid absorption RNA POLYMERASE I PROMOTER OPENING%REACTOME DATABASE ID RELEASE 66%10144847 RNA Polymerase I Promoter Opening INTEGRIN CELL SURFACE INTERACTIONS%REACTOME%R-RNO-216083.1 Integrin cell surface interactions TNFR2 NON-CANONICAL NF-KB PATHWAY%REACTOME DATABASE ID RELEASE 66%10145373 TNFR2 non-canonical NF-kB pathway N-GLYCAN TRIMMING AND ELONGATION IN THE CIS-GOLGI%REACTOME DATABASE ID RELEASE 66%10145771 N-glycan trimming and elongation in the cis-Golgi FRS-MEDIATED FGFR4 SIGNALING%REACTOME DATABASE ID RELEASE 66%10146106 FRS-mediated FGFR4 signaling G-PROTEIN ACTIVATION%REACTOME%R-RNO-202040.1 G-protein activation OXIDATIVE STRESS INDUCED SENESCENCE%REACTOME DATABASE ID RELEASE 66%10145165 Oxidative Stress Induced Senescence TACHYKININ RECEPTORS BIND TACHYKININS%REACTOME DATABASE ID RELEASE 66%10145521 Tachykinin receptors bind tachykinins GLOBAL GENOME NUCLEOTIDE EXCISION REPAIR (GG-NER)%REACTOME%R-RNO-5696399.1 Global Genome Nucleotide Excision Repair (GG-NER) CENTROSOME MATURATION%REACTOME%R-RNO-380287.1 Centrosome maturation CHROMATIN ORGANIZATION%REACTOME DATABASE ID RELEASE 66%10145803 Chromatin organization EXTENSION OF TELOMERES%REACTOME DATABASE ID RELEASE 66%10145111 Extension of Telomeres CDO IN MYOGENESIS%REACTOME DATABASE ID RELEASE 66%10145503 CDO in myogenesis GAP JUNCTION TRAFFICKING AND REGULATION%REACTOME DATABASE ID RELEASE 66%10145298 Gap junction trafficking and regulation GLUTATHIONE SYNTHESIS AND RECYCLING%REACTOME%R-RNO-174403.1 Glutathione synthesis and recycling INTERLEUKIN-3, INTERLEUKIN-5 AND GM-CSF SIGNALING%REACTOME DATABASE ID RELEASE 66%10145705 Interleukin-3, Interleukin-5 and GM-CSF signaling ACYL CHAIN REMODELLING OF PC%REACTOME%R-RNO-1482788.1 Acyl chain remodelling of PC INTERLEUKIN-1 SIGNALING%REACTOME%R-RNO-9020702.1 Interleukin-1 signaling G0 AND EARLY G1%REACTOME%R-RNO-1538133.1 G0 and Early G1 ACTIVATION OF CAMK IV%REACTOME%R-RNO-442745.1 Activation of CaMK IV ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%R-RNO-1296041.1 Activation of G protein gated Potassium channels DUAL INCISION IN TC-NER%REACTOME%R-RNO-6782135.1 Dual incision in TC-NER CYTOSOLIC TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 66%10144822 Cytosolic tRNA aminoacylation ELECTRON TRANSPORT FROM NADPH TO FERREDOXIN%REACTOME%R-RNO-2395516.1 Electron transport from NADPH to Ferredoxin VEGF LIGAND-RECEPTOR INTERACTIONS%REACTOME DATABASE ID RELEASE 66%10145339 VEGF ligand-receptor interactions YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION%REACTOME%R-RNO-2032785.1 YAP1- and WWTR1 (TAZ)-stimulated gene expression DNA REPAIR%REACTOME DATABASE ID RELEASE 66%10144763 DNA Repair REGULATION OF NECROPTOTIC CELL DEATH%REACTOME DATABASE ID RELEASE 66%10146017 Regulation of necroptotic cell death INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1%REACTOME DATABASE ID RELEASE 66%10145013 Inhibition of replication initiation of damaged DNA by RB1 E2F1 RECOGNITION OF DNA DAMAGE BY PCNA-CONTAINING REPLICATION COMPLEX%REACTOME DATABASE ID RELEASE 66%10146094 Recognition of DNA damage by PCNA-containing replication complex SYNAPTIC ADHESION-LIKE MOLECULES%REACTOME DATABASE ID RELEASE 66%10146209 Synaptic adhesion-like molecules VEGF BINDS TO VEGFR LEADING TO RECEPTOR DIMERIZATION%REACTOME DATABASE ID RELEASE 66%10145338 VEGF binds to VEGFR leading to receptor dimerization THE ACTIVATION OF ARYLSULFATASES%REACTOME DATABASE ID RELEASE 66%10145887 The activation of arylsulfatases LINOLEIC ACID (LA) METABOLISM%REACTOME DATABASE ID RELEASE 66%10145933 Linoleic acid (LA) metabolism FORMATION OF ANNULAR GAP JUNCTIONS%REACTOME%R-RNO-196025.1 Formation of annular gap junctions CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM%REACTOME DATABASE ID RELEASE 66%10145886 Chondroitin sulfate dermatan sulfate metabolism INTERLEUKIN-12 FAMILY SIGNALING%REACTOME%R-RNO-447115.1 Interleukin-12 family signaling TOLL LIKE RECEPTOR 10 (TLR10) CASCADE%REACTOME%R-RNO-168142.1 Toll Like Receptor 10 (TLR10) Cascade BIOSYNTHESIS OF ASPIRIN-TRIGGERED D-SERIES RESOLVINS%REACTOME%R-RNO-9020265.1 Biosynthesis of aspirin-triggered D-series resolvins ADENYLATE CYCLASE INHIBITORY PATHWAY%REACTOME DATABASE ID RELEASE 66%10145186 Adenylate cyclase inhibitory pathway HYDROLYSIS OF LPC%REACTOME%R-RNO-1483115.1 Hydrolysis of LPC PRE-NOTCH EXPRESSION AND PROCESSING%REACTOME DATABASE ID RELEASE 66%10145916 Pre-NOTCH Expression and Processing CD22 MEDIATED BCR REGULATION%REACTOME DATABASE ID RELEASE 66%10146141 CD22 mediated BCR regulation ACTIVATION OF NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%R-RNO-629602.1 Activation of Nicotinic Acetylcholine Receptors TRANSCRIPTION FROM MITOCHONDRIAL PROMOTERS%REACTOME DATABASE ID RELEASE 66%10145118 Transcription from mitochondrial promoters DOPAMINE RECEPTORS%REACTOME%R-RNO-390651.1 Dopamine receptors SYNTHESIS OF EPOXY (EET) AND DIHYDROXYEICOSATRIENOIC ACIDS (DHET)%REACTOME DATABASE ID RELEASE 66%10145947 Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK%REACTOME DATABASE ID RELEASE 66%10145383 Energy dependent regulation of mTOR by LKB1-AMPK BIOSYNTHESIS OF E-SERIES 18(S)-RESOLVINS%REACTOME%R-RNO-9018896.1 Biosynthesis of E-series 18(S)-resolvins SYNTHESIS OF PA%REACTOME DATABASE ID RELEASE 66%10144907 Synthesis of PA NOSTRIN MEDIATED ENOS TRAFFICKING%REACTOME%R-RNO-203641.1 NOSTRIN mediated eNOS trafficking DEPYRIMIDINATION%REACTOME DATABASE ID RELEASE 66%10144972 Depyrimidination PHYSIOLOGICAL FACTORS%REACTOME%R-RNO-5578768.1 Physiological factors JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1%REACTOME%R-RNO-450321.1 JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 DNA STRAND ELONGATION%REACTOME%R-RNO-69190.1 DNA strand elongation INTERFERON ALPHA BETA SIGNALING%REACTOME%R-RNO-909733.1 Interferon alpha beta signaling TOLL-LIKE RECEPTOR CASCADES%REACTOME DATABASE ID RELEASE 66%10145131 Toll-like Receptor Cascades RESOLUTION OF SISTER CHROMATID COHESION%REACTOME DATABASE ID RELEASE 66%10145894 Resolution of Sister Chromatid Cohesion GPVI-MEDIATED ACTIVATION CASCADE%REACTOME%R-RNO-114604.1 GPVI-mediated activation cascade NADE MODULATES DEATH SIGNALLING%REACTOME DATABASE ID RELEASE 66%10145330 NADE modulates death signalling RHO GTPASES ACTIVATE RHOTEKIN AND RHOPHILINS%REACTOME DATABASE ID RELEASE 66%10146121 RHO GTPases Activate Rhotekin and Rhophilins PROSTANOID LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145568 Prostanoid ligand receptors PACKAGING OF TELOMERE ENDS%REACTOME%R-RNO-171306.1 Packaging Of Telomere Ends ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING%REACTOME DATABASE ID RELEASE 66%10145740 Advanced glycosylation endproduct receptor signaling TP53 REGULATES TRANSCRIPTION OF CELL DEATH GENES%REACTOME%R-RNO-5633008.1 TP53 Regulates Transcription of Cell Death Genes FGFR2C LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 66%10145288 FGFR2c ligand binding and activation PLASMA LIPOPROTEIN ASSEMBLY%REACTOME%R-RNO-8963898.1 Plasma lipoprotein assembly ACTIVATED NTRK2 SIGNALS THROUGH FRS2 AND FRS3%REACTOME%R-RNO-9028731.1 Activated NTRK2 signals through FRS2 and FRS3 E2F MEDIATED REGULATION OF DNA REPLICATION%REACTOME DATABASE ID RELEASE 66%10145014 E2F mediated regulation of DNA replication TOLL LIKE RECEPTOR 2 (TLR2) CASCADE%REACTOME%R-RNO-181438.1 Toll Like Receptor 2 (TLR2) Cascade TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION%REACTOME%R-RNO-1474151.1 Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation RHO GTPASES ACTIVATE NADPH OXIDASES%REACTOME DATABASE ID RELEASE 66%10146047 RHO GTPases Activate NADPH Oxidases DOWNREGULATION OF ERBB2:ERBB3 SIGNALING%REACTOME%R-RNO-1358803.1 Downregulation of ERBB2:ERBB3 signaling CELL-CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 66%10145495 Cell-cell junction organization SYNTHESIS OF IPS IN THE NUCLEUS%REACTOME%R-RNO-1855191.1 Synthesis of IPs in the nucleus SYNTHESIS OF DNA%REACTOME DATABASE ID RELEASE 66%10144719 Synthesis of DNA SYNTHESIS OF BILE ACIDS AND BILE SALTS%REACTOME DATABASE ID RELEASE 66%10145312 Synthesis of bile acids and bile salts APOPTOTIC FACTOR-MEDIATED RESPONSE%REACTOME%R-RNO-111471.1 Apoptotic factor-mediated response GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT%REACTOME%R-RNO-72706.1 GTP hydrolysis and joining of the 60S ribosomal subunit INTRA-GOLGI AND RETROGRADE GOLGI-TO-ER TRAFFIC%REACTOME DATABASE ID RELEASE 66%10146192 Intra-Golgi and retrograde Golgi-to-ER traffic SIGNALING BY RECEPTOR TYROSINE KINASES%REACTOME DATABASE ID RELEASE 66%10144877 Signaling by Receptor Tyrosine Kinases TRANS-GOLGI NETWORK VESICLE BUDDING%REACTOME DATABASE ID RELEASE 66%10145468 trans-Golgi Network Vesicle Budding LIGAND-INDEPENDENT CASPASE ACTIVATION VIA DCC%REACTOME DATABASE ID RELEASE 66%10145489 Ligand-independent caspase activation via DCC IONOTROPIC ACTIVITY OF KAINATE RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145699 Ionotropic activity of kainate receptors SMAC-MEDIATED DISSOCIATION OF IAP:CASPASE COMPLEXES%REACTOME%R-RNO-111464.1 SMAC-mediated dissociation of IAP:caspase complexes MITOTIC G1-G1 S PHASES%REACTOME DATABASE ID RELEASE 66%10144725 Mitotic G1-G1 S phases HEME DEGRADATION%REACTOME%R-RNO-189483.1 Heme degradation BIOSYNTHESIS OF DPAN-3-DERIVED MARESINS%REACTOME%R-RNO-9026290.1 Biosynthesis of DPAn-3-derived maresins TP53 REGULATES TRANSCRIPTION OF ADDITIONAL CELL CYCLE GENES WHOSE EXACT ROLE IN THE P53 PATHWAY REMAIN UNCERTAIN%REACTOME%R-RNO-6804115.1 TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain FGFR3 LIGAND BINDING AND ACTIVATION%REACTOME%R-RNO-190239.1 FGFR3 ligand binding and activation MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 66%10145043 Muscle contraction DEATH RECEPTOR SIGNALLING%REACTOME DATABASE ID RELEASE 66%10144808 Death Receptor Signalling DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR)%REACTOME DATABASE ID RELEASE 66%10145798 Downstream signaling events of B Cell Receptor (BCR) TNFR1-INDUCED PROAPOPTOTIC SIGNALING%REACTOME DATABASE ID RELEASE 66%10144945 TNFR1-induced proapoptotic signaling KSRP (KHSRP) BINDS AND DESTABILIZES MRNA%REACTOME DATABASE ID RELEASE 66%10145696 KSRP (KHSRP) binds and destabilizes mRNA BIOSYNTHESIS OF PROTECTINS%REACTOME%R-RNO-9018681.1 Biosynthesis of protectins SIGNALING BY ERYTHROPOIETIN%REACTOME DATABASE ID RELEASE 66%10146295 Signaling by Erythropoietin DISINHIBITION OF SNARE FORMATION%REACTOME DATABASE ID RELEASE 66%10145035 Disinhibition of SNARE formation CATECHOLAMINE BIOSYNTHESIS%REACTOME%R-RNO-209905.1 Catecholamine biosynthesis TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES%REACTOME%R-RNO-425393.1 Transport of inorganic cations anions and amino acids oligopeptides SIGNAL ATTENUATION%REACTOME%R-RNO-74749.1 Signal attenuation NONHOMOLOGOUS END-JOINING (NHEJ)%REACTOME%R-RNO-5693571.1 Nonhomologous End-Joining (NHEJ) BASIGIN INTERACTIONS%REACTOME%R-RNO-210991.1 Basigin interactions SUMO IS CONJUGATED TO E1 (UBA2:SAE1)%REACTOME DATABASE ID RELEASE 66%10145983 SUMO is conjugated to E1 (UBA2:SAE1) NUCLEAR SIGNALING BY ERBB4%REACTOME%R-RNO-1251985.1 Nuclear signaling by ERBB4 LIPOPROTEIN METABOLISM%REACTOME DATABASE ID RELEASE 66%10145205 Lipoprotein metabolism CA ACTIVATED K+ CHANNELS%REACTOME DATABASE ID RELEASE 66%10145832 Ca activated K+ channels SYNTHESIS OF IPS IN THE ER LUMEN%REACTOME%R-RNO-1855231.1 Synthesis of IPs in the ER lumen LEUKOTRIENE RECEPTORS%REACTOME%R-RNO-391906.1 Leukotriene receptors CELL JUNCTION ORGANIZATION%REACTOME%R-RNO-446728.1 Cell junction organization PHOSPHORYLATION OF THE APC C%REACTOME DATABASE ID RELEASE 66%10145220 Phosphorylation of the APC C ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY%REACTOME DATABASE ID RELEASE 66%10145655 Zinc influx into cells by the SLC39 gene family P75 NTR RECEPTOR-MEDIATED SIGNALLING%REACTOME%R-RNO-193704.1 p75 NTR receptor-mediated signalling METABOLISM%REACTOME DATABASE ID RELEASE 66%10144767 Metabolism XBP1(S) ACTIVATES CHAPERONE GENES%REACTOME%R-RNO-381038.1 XBP1(S) activates chaperone genes COPI-MEDIATED ANTEROGRADE TRANSPORT%REACTOME%R-RNO-6807878.1 COPI-mediated anterograde transport INTERLEUKIN-12 SIGNALING%REACTOME DATABASE ID RELEASE 66%10145676 Interleukin-12 signaling NONSENSE-MEDIATED DECAY (NMD)%REACTOME%R-RNO-927802.1 Nonsense-Mediated Decay (NMD) REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE%REACTOME%R-RNO-3371453.1 Regulation of HSF1-mediated heat shock response TRANSCRIPTIONAL REGULATION BY TP53%REACTOME DATABASE ID RELEASE 66%10144748 Transcriptional Regulation by TP53 ROBO RECEPTORS BIND AKAP5%REACTOME%R-RNO-9010642.1 ROBO receptors bind AKAP5 INTERLEUKIN-35 SIGNALLING%REACTOME DATABASE ID RELEASE 66%10145680 Interleukin-35 Signalling TRANSLATION%REACTOME%R-RNO-72766.1 Translation TP53 REGULATES TRANSCRIPTION OF CASPASE ACTIVATORS AND CASPASES%REACTOME%R-RNO-6803207.1 TP53 Regulates Transcription of Caspase Activators and Caspases VISUAL PHOTOTRANSDUCTION%REACTOME%R-RNO-2187338.1 Visual phototransduction ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS%REACTOME DATABASE ID RELEASE 66%10145358 Role of phospholipids in phagocytosis TRAF6-MEDIATED INDUCTION OF TAK1 COMPLEX WITHIN TLR4 COMPLEX%REACTOME DATABASE ID RELEASE 66%10145767 TRAF6-mediated induction of TAK1 complex within TLR4 complex TRKA ACTIVATION BY NGF%REACTOME DATABASE ID RELEASE 66%10145140 TRKA activation by NGF AQUAPORIN-MEDIATED TRANSPORT%REACTOME DATABASE ID RELEASE 66%10145007 Aquaporin-mediated transport CHK1 CHK2(CDS1) MEDIATED INACTIVATION OF CYCLIN B:CDK1 COMPLEX%REACTOME%R-RNO-75035.1 Chk1 Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex NEURONAL SYSTEM%REACTOME DATABASE ID RELEASE 66%10144791 Neuronal System SIGNAL REGULATORY PROTEIN FAMILY INTERACTIONS%REACTOME DATABASE ID RELEASE 66%10145430 Signal regulatory protein family interactions RHO GTPASES ACTIVATE ROCKS%REACTOME%R-RNO-5627117.1 RHO GTPases Activate ROCKs TRIF(TICAM1)-MEDIATED TLR4 SIGNALING%REACTOME DATABASE ID RELEASE 66%10145138 TRIF(TICAM1)-mediated TLR4 signaling REGULATION OF TP53 DEGRADATION%REACTOME DATABASE ID RELEASE 66%10145361 Regulation of TP53 Degradation VITAMIN B1 (THIAMIN) METABOLISM%REACTOME%R-RNO-196819.1 Vitamin B1 (thiamin) metabolism E3 UBIQUITIN LIGASES UBIQUITINATE TARGET PROTEINS%REACTOME%R-RNO-8866654.1 E3 ubiquitin ligases ubiquitinate target proteins RESOLUTION OF D-LOOP STRUCTURES THROUGH SYNTHESIS-DEPENDENT STRAND ANNEALING (SDSA)%REACTOME DATABASE ID RELEASE 66%10146147 Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) TWIK RELATED POTASSIUM CHANNEL (TREK)%REACTOME DATABASE ID RELEASE 66%10145838 TWIK related potassium channel (TREK) REGULATION OF BETA-CELL DEVELOPMENT%REACTOME DATABASE ID RELEASE 66%10145438 Regulation of beta-cell development PROCESSIVE SYNTHESIS ON THE LAGGING STRAND%REACTOME%R-RNO-69183.1 Processive synthesis on the lagging strand CARBOXYTERMINAL POST-TRANSLATIONAL MODIFICATIONS OF TUBULIN%REACTOME%R-RNO-8955332.1 Carboxyterminal post-translational modifications of tubulin APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME DATABASE ID RELEASE 66%10145218 APC C:Cdc20 mediated degradation of mitotic proteins DEGRADATION OF AXIN%REACTOME DATABASE ID RELEASE 66%10146020 Degradation of AXIN DNA DAMAGE BYPASS%REACTOME DATABASE ID RELEASE 66%10144978 DNA Damage Bypass SIGNALING BY ACTIVIN%REACTOME%R-RNO-1502540.1 Signaling by Activin CELL DIVISION%REACTOME%R-RNO-68884.1 cell division OAS ANTIVIRAL RESPONSE%REACTOME DATABASE ID RELEASE 66%10146284 OAS antiviral response PKA-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%R-RNO-111931.1 PKA-mediated phosphorylation of CREB RHO GTPASES ACTIVATE WASPS AND WAVES%REACTOME DATABASE ID RELEASE 66%10145928 RHO GTPases Activate WASPs and WAVEs SNRNP ASSEMBLY%REACTOME%R-RNO-191859.1 snRNP Assembly CHROMOSOME MAINTENANCE%REACTOME DATABASE ID RELEASE 66%10145113 Chromosome Maintenance TRANSCRIPTIONAL REGULATION BY RUNX1%REACTOME DATABASE ID RELEASE 66%10146236 Transcriptional regulation by RUNX1 AFLATOXIN ACTIVATION AND DETOXIFICATION%REACTOME DATABASE ID RELEASE 66%10145070 Aflatoxin activation and detoxification SEROTONIN AND MELATONIN BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 66%10145426 Serotonin and melatonin biosynthesis N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI%REACTOME%R-RNO-975576.1 N-glycan antennae elongation in the medial trans-Golgi HYDROLYSIS OF LPE%REACTOME%R-RNO-1483152.1 Hydrolysis of LPE ACTIVATED NTRK3 SIGNALS THROUGH PI3K%REACTOME%R-RNO-9603381.1 Activated NTRK3 signals through PI3K SIGNAL TRANSDUCTION BY L1%REACTOME%R-RNO-445144.1 Signal transduction by L1 PDE3B SIGNALLING%REACTOME%R-RNO-165160.1 PDE3B signalling IRS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 66%10144880 IRS-mediated signalling TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE%REACTOME DATABASE ID RELEASE 66%10145154 Toll Like Receptor 7 8 (TLR7 8) Cascade ATP SENSITIVE POTASSIUM CHANNELS%REACTOME DATABASE ID RELEASE 66%10145831 ATP sensitive Potassium channels COOPERATION OF PDCL (PHLP1) AND TRIC CCT IN G-PROTEIN BETA FOLDING%REACTOME DATABASE ID RELEASE 66%10146196 Cooperation of PDCL (PhLP1) and TRiC CCT in G-protein beta folding NRIF SIGNALS CELL DEATH FROM THE NUCLEUS%REACTOME DATABASE ID RELEASE 66%10145334 NRIF signals cell death from the nucleus CD209 (DC-SIGN) SIGNALING%REACTOME%R-RNO-5621575.1 CD209 (DC-SIGN) signaling ANTIMICROBIAL PEPTIDES%REACTOME%R-RNO-6803157.1 Antimicrobial peptides VITAMIN C (ASCORBATE) METABOLISM%REACTOME DATABASE ID RELEASE 66%10145368 Vitamin C (ascorbate) metabolism DEUBIQUITINATION%REACTOME DATABASE ID RELEASE 66%10145726 Deubiquitination AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS%REACTOME DATABASE ID RELEASE 66%10145371 AKT phosphorylates targets in the nucleus INFLAMMASOMES%REACTOME DATABASE ID RELEASE 66%10145733 Inflammasomes PROCESSING OF SMDT1%REACTOME%R-RNO-8949664.1 Processing of SMDT1 COPII-MEDIATED VESICLE TRANSPORT%REACTOME%R-RNO-204005.1 COPII-mediated vesicle transport IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME DATABASE ID RELEASE 66%10145773 IRAK2 mediated activation of TAK1 complex upon TLR7 8 or 9 stimulation BIOSYNTHESIS OF DPAN-3 SPMS%REACTOME%R-RNO-9025094.1 Biosynthesis of DPAn-3 SPMs SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS%REACTOME DATABASE ID RELEASE 66%10144939 SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE%REACTOME%R-RNO-4641262.1 Disassembly of the destruction complex and recruitment of AXIN to the membrane COLLAGEN DEGRADATION%REACTOME DATABASE ID RELEASE 66%10145855 Collagen degradation PROTEIN REPAIR%REACTOME%R-RNO-5676934.1 Protein repair ACROSOME REACTION%REACTOME%R-RNO-1300645.1 Acrosome Reaction PKA ACTIVATION%REACTOME%R-RNO-163615.1 PKA activation PROCESSING OF INTRONLESS PRE-MRNAS%REACTOME DATABASE ID RELEASE 66%10144941 Processing of Intronless Pre-mRNAs NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 66%10145491 Netrin-1 signaling FMO OXIDISES NUCLEOPHILES%REACTOME%R-RNO-217271.1 FMO oxidises nucleophiles ASTROCYTIC GLUTAMATE-GLUTAMINE UPTAKE AND METABOLISM%REACTOME%R-RNO-210455.1 Astrocytic Glutamate-Glutamine Uptake And Metabolism RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES%REACTOME%R-RNO-380270.1 Recruitment of mitotic centrosome proteins and complexes METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS%REACTOME%R-RNO-196849.1 Metabolism of water-soluble vitamins and cofactors CELLULAR RESPONSE TO HYPOXIA%REACTOME%R-RNO-2262749.1 Cellular response to hypoxia PHOSPHOLIPASE C-MEDIATED CASCADE; FGFR4%REACTOME DATABASE ID RELEASE 66%10146101 Phospholipase C-mediated cascade; FGFR4 CROSSLINKING OF COLLAGEN FIBRILS%REACTOME DATABASE ID RELEASE 66%10145923 Crosslinking of collagen fibrils CELL SURFACE INTERACTIONS AT THE VASCULAR WALL%REACTOME DATABASE ID RELEASE 66%10145033 Cell surface interactions at the vascular wall FORMATION OF THE EDITOSOME%REACTOME DATABASE ID RELEASE 66%10144942 Formation of the Editosome ACTIVATION OF NOXA AND TRANSLOCATION TO MITOCHONDRIA%REACTOME DATABASE ID RELEASE 66%10145050 Activation of NOXA and translocation to mitochondria REGULATION OF THYROID HORMONE ACTIVITY%REACTOME DATABASE ID RELEASE 66%10145423 Regulation of thyroid hormone activity SODIUM-COUPLED SULPHATE, DI- AND TRI-CARBOXYLATE TRANSPORTERS%REACTOME DATABASE ID RELEASE 66%10145648 Sodium-coupled sulphate, di- and tri-carboxylate transporters APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1%REACTOME%R-RNO-174178.1 APC C:Cdh1 mediated degradation of Cdc20 and other APC C:Cdh1 targeted proteins in late mitosis early G1 BIOSYNTHESIS OF DPAN-3-DERIVED 13-SERIES RESOLVINS%REACTOME%R-RNO-9026403.1 Biosynthesis of DPAn-3-derived 13-series resolvins TP53 REGULATES TRANSCRIPTION OF DEATH RECEPTORS AND LIGANDS%REACTOME%R-RNO-6803211.1 TP53 Regulates Transcription of Death Receptors and Ligands O2 CO2 EXCHANGE IN ERYTHROCYTES%REACTOME DATABASE ID RELEASE 66%10145818 O2 CO2 exchange in erythrocytes FGFR2B LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 66%10145290 FGFR2b ligand binding and activation RAF ACTIVATION%REACTOME DATABASE ID RELEASE 66%10146124 RAF activation ARMS-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 66%10145180 ARMS-mediated activation GRB2 EVENTS IN EGFR SIGNALING%REACTOME%R-RNO-179812.1 GRB2 events in EGFR signaling HS-GAG BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 66%10145730 HS-GAG biosynthesis STAT6-MEDIATED INDUCTION OF CHEMOKINES%REACTOME%R-RNO-3249367.1 STAT6-mediated induction of chemokines DEGRADATION OF GABA%REACTOME DATABASE ID RELEASE 66%10145745 Degradation of GABA BIOSYNTHESIS OF E-SERIES 18(R)-RESOLVINS%REACTOME DATABASE ID RELEASE 66%10146300 Biosynthesis of E-series 18(R)-resolvins DNA DOUBLE STRAND BREAK RESPONSE%REACTOME%R-RNO-5693606.1 DNA Double Strand Break Response REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN%REACTOME DATABASE ID RELEASE 66%10145192 Regulation of Glucokinase by Glucokinase Regulatory Protein CYTOSOLIC SULFONATION OF SMALL MOLECULES%REACTOME%R-RNO-156584.1 Cytosolic sulfonation of small molecules CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS%REACTOME%R-RNO-264870.1 Caspase-mediated cleavage of cytoskeletal proteins DISPLACEMENT OF DNA GLYCOSYLASE BY APEX1%REACTOME%R-RNO-110357.1 Displacement of DNA glycosylase by APEX1 NICOTINAMIDE SALVAGING%REACTOME%R-RNO-197264.1 Nicotinamide salvaging TELOMERE MAINTENANCE%REACTOME DATABASE ID RELEASE 66%10145112 Telomere Maintenance RECYCLING OF EIF2:GDP%REACTOME%R-RNO-72731.1 Recycling of eIF2:GDP CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE%REACTOME DATABASE ID RELEASE 66%10144920 Cytochrome P450 - arranged by substrate type UB-SPECIFIC PROCESSING PROTEASES%REACTOME%R-RNO-5689880.1 Ub-specific processing proteases O-GLYCOSYLATION OF TSR DOMAIN-CONTAINING PROTEINS%REACTOME DATABASE ID RELEASE 66%10146044 O-glycosylation of TSR domain-containing proteins TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT%REACTOME DATABASE ID RELEASE 66%10144895 Transport of Mature mRNA derived from an Intron-Containing Transcript MET ACTIVATES PI3K AKT SIGNALING%REACTOME%R-RNO-8851907.1 MET activates PI3K AKT signaling NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME DATABASE ID RELEASE 66%10145957 NOTCH2 intracellular domain regulates transcription RET SIGNALING%REACTOME DATABASE ID RELEASE 66%10146221 RET signaling CLATHRIN-MEDIATED ENDOCYTOSIS%REACTOME DATABASE ID RELEASE 66%10146228 Clathrin-mediated endocytosis FGFR2 ALTERNATIVE SPLICING%REACTOME%R-RNO-6803529.1 FGFR2 alternative splicing NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME DATABASE ID RELEASE 66%10145624 Negative epigenetic regulation of rRNA expression C-TYPE LECTIN RECEPTORS (CLRS)%REACTOME%R-RNO-5621481.1 C-type lectin receptors (CLRs) TRANSPORT OF CONNEXINS ALONG THE SECRETORY PATHWAY%REACTOME DATABASE ID RELEASE 66%215126 Transport of connexins along the secretory pathway BICARBONATE TRANSPORTERS%REACTOME DATABASE ID RELEASE 66%10145616 Bicarbonate transporters HEMOSTASIS%REACTOME DATABASE ID RELEASE 66%10145028 Hemostasis BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS%REACTOME%R-RNO-111453.1 BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members POSITIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%R-RNO-5250913.1 Positive epigenetic regulation of rRNA expression DEGRADATION OF CYSTEINE AND HOMOCYSTEINE%REACTOME DATABASE ID RELEASE 66%10145890 Degradation of cysteine and homocysteine TRANSPORT OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 66%10144953 Transport of small molecules INTERLEUKIN-1 PROCESSING%REACTOME%R-RNO-448706.1 Interleukin-1 processing FC EPSILON RECEPTOR (FCERI) SIGNALING%REACTOME DATABASE ID RELEASE 66%10145167 Fc epsilon receptor (FCERI) signaling SEROTONIN RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145563 Serotonin receptors REVERSAL OF ALKYLATION DAMAGE BY DNA DIOXYGENASES%REACTOME DATABASE ID RELEASE 66%10146230 Reversal of alkylation damage by DNA dioxygenases PROTEIN-PROTEIN INTERACTIONS AT SYNAPSES%REACTOME%R-RNO-6794362.1 Protein-protein interactions at synapses MET PROMOTES CELL MOTILITY%REACTOME DATABASE ID RELEASE 66%10146247 MET promotes cell motility MRNA EDITING: C TO U CONVERSION%REACTOME%R-RNO-72200.1 mRNA Editing: C to U Conversion ECM PROTEOGLYCANS%REACTOME%R-RNO-3000178.1 ECM proteoglycans P38MAPK EVENTS%REACTOME DATABASE ID RELEASE 66%10145201 p38MAPK events INNATE IMMUNE SYSTEM%REACTOME%R-RNO-168249.1 Innate Immune System TRANSMISSION ACROSS ELECTRICAL SYNAPSES%REACTOME DATABASE ID RELEASE 66%10145508 Transmission across Electrical Synapses EPHA-MEDIATED GROWTH CONE COLLAPSE%REACTOME DATABASE ID RELEASE 66%10146028 EPHA-mediated growth cone collapse IRF3 MEDIATED ACTIVATION OF TYPE 1 IFN%REACTOME%R-RNO-1606341.1 IRF3 mediated activation of type 1 IFN HDL REMODELING%REACTOME DATABASE ID RELEASE 66%10145453 HDL remodeling SIGNALING BY GPCR%REACTOME DATABASE ID RELEASE 66%10144870 Signaling by GPCR ELASTIC FIBRE FORMATION%REACTOME%R-RNO-1566948.1 Elastic fibre formation FGFR4 LIGAND BINDING AND ACTIVATION%REACTOME%R-RNO-190322.1 FGFR4 ligand binding and activation INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION%REACTOME%R-RNO-400508.1 Incretin synthesis, secretion, and inactivation METALLOTHIONEINS BIND METALS%REACTOME%R-RNO-5661231.1 Metallothioneins bind metals INSULIN PROCESSING%REACTOME DATABASE ID RELEASE 66%10145456 Insulin processing ANCHORING FIBRIL FORMATION%REACTOME%R-RNO-2214320.1 Anchoring fibril formation MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF UNSATURATED FATTY ACIDS%REACTOME DATABASE ID RELEASE 66%10144949 mitochondrial fatty acid beta-oxidation of unsaturated fatty acids SCAVENGING BY CLASS A RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145956 Scavenging by Class A Receptors CLATHRIN DERIVED VESICLE BUDDING%REACTOME%R-RNO-421837.1 Clathrin derived vesicle budding SCAVENGING BY CLASS H RECEPTORS%REACTOME DATABASE ID RELEASE 66%10145959 Scavenging by Class H Receptors POLB-DEPENDENT LONG PATCH BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 66%10146093 POLB-Dependent Long Patch Base Excision Repair MACROAUTOPHAGY%REACTOME%R-RNO-1632852.1 Macroautophagy GOLGI ASSOCIATED VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 66%10145614 Golgi Associated Vesicle Biogenesis HEDGEHOG LIGAND BIOGENESIS%REACTOME%R-RNO-5358346.1 Hedgehog ligand biogenesis SIGNALING BY NTRK3 (TRKC)%REACTOME DATABASE ID RELEASE 66%10146326 Signaling by NTRK3 (TRKC) SIGNALING BY NTRK2 (TRKB)%REACTOME DATABASE ID RELEASE 66%10146316 Signaling by NTRK2 (TRKB) NEGATIVE REGULATION OF NOTCH4 SIGNALING%REACTOME DATABASE ID RELEASE 66%10146331 Negative regulation of NOTCH4 signaling ERBB2 ACTIVATES PTK6 SIGNALING%REACTOME%R-RNO-8847993.1 ERBB2 Activates PTK6 Signaling WNT MEDIATED ACTIVATION OF DVL%REACTOME DATABASE ID RELEASE 66%10145393 WNT mediated activation of DVL DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY%REACTOME%R-RNO-2173795.1 Downregulation of SMAD2 3:SMAD4 transcriptional activity REGULATION OF IGF ACTIVITY BY IGFBP%REACTOME%R-RNO-381426.1 Regulation of IGF Activity by IGFBP EUKARYOTIC TRANSLATION TERMINATION%REACTOME DATABASE ID RELEASE 66%10146146 Eukaryotic Translation Termination ACTIVATED NTRK3 SIGNALS THROUGH PLCG1%REACTOME DATABASE ID RELEASE 66%10146327 Activated NTRK3 signals through PLCG1 THE NLRP1 INFLAMMASOME%REACTOME DATABASE ID RELEASE 66%10145732 The NLRP1 inflammasome SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP)%REACTOME%R-RNO-400511.1 Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER%REACTOME%R-RNO-76061.1 RNA Polymerase III Transcription Initiation From Type 1 Promoter TRANSCRIPTIONAL REGULATION BY MECP2%REACTOME%R-RNO-8986944.1 Transcriptional Regulation by MECP2 MITOCHONDRIAL TRANSLATION%REACTOME%R-RNO-5368287.1 Mitochondrial translation PROTEIN LOCALIZATION%REACTOME DATABASE ID RELEASE 66%10146283 Protein localization CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX%REACTOME%R-RNO-68689.1 CDC6 association with the ORC:origin complex RESOLUTION OF D-LOOP STRUCTURES%REACTOME%R-RNO-5693537.1 Resolution of D-Loop Structures SPHINGOLIPID DE NOVO BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 66%10145630 Sphingolipid de novo biosynthesis CLEARANCE OF DOPAMINE%REACTOME%R-RNO-379401.1 Clearance of dopamine GABA SYNTHESIS%REACTOME DATABASE ID RELEASE 66%10145746 GABA synthesis SUMOYLATION OF TRANSCRIPTION COFACTORS%REACTOME DATABASE ID RELEASE 66%10145995 SUMOylation of transcription cofactors SIGNALING BY WNT%REACTOME DATABASE ID RELEASE 66%10145342 Signaling by WNT ESTROGEN BIOSYNTHESIS%REACTOME%R-RNO-193144.1 Estrogen biosynthesis SUMOYLATION OF CHROMATIN ORGANIZATION PROTEINS%REACTOME%R-RNO-4551638.1 SUMOylation of chromatin organization proteins CLEAVAGE OF THE DAMAGED PURINE%REACTOME DATABASE ID RELEASE 66%10144974 Cleavage of the damaged purine DEPOLYMERISATION OF THE NUCLEAR LAMINA%REACTOME DATABASE ID RELEASE 66%10146031 Depolymerisation of the Nuclear Lamina EPIGENETIC REGULATION OF GENE EXPRESSION%REACTOME DATABASE ID RELEASE 66%10145445 Epigenetic regulation of gene expression REACTIONS SPECIFIC TO THE HYBRID N-GLYCAN SYNTHESIS PATHWAY%REACTOME%R-RNO-975574.1 Reactions specific to the hybrid N-glycan synthesis pathway RHO GTPASES ACTIVATE PAKS%REACTOME%R-RNO-5627123.1 RHO GTPases activate PAKs DEGRADATION OF DVL%REACTOME DATABASE ID RELEASE 66%10145877 Degradation of DVL TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS%REACTOME DATABASE ID RELEASE 66%10145193 TGF-beta receptor signaling activates SMADs PYRUVATE METABOLISM%REACTOME%R-RNO-70268.1 Pyruvate metabolism PLATELET ACTIVATION, SIGNALING AND AGGREGATION%REACTOME DATABASE ID RELEASE 66%10145027 Platelet activation, signaling and aggregation LOSS OF NLP FROM MITOTIC CENTROSOMES%REACTOME%R-RNO-380259.1 Loss of Nlp from mitotic centrosomes CAM PATHWAY%REACTOME DATABASE ID RELEASE 66%10144992 CaM pathway SIGNALING BY SCF-KIT%REACTOME DATABASE ID RELEASE 66%10145420 Signaling by SCF-KIT TIGHT JUNCTION INTERACTIONS%REACTOME%R-RNO-420029.1 Tight junction interactions NUCLEOTIDE METABOLISM%REACTOME DATABASE ID RELEASE 66%10144816 Nucleotide metabolism INHIBITION OF ADENYLATE CYCLASE PATHWAY%REACTOME%R-RNO-997269.1 Inhibition of adenylate cyclase pathway RNA POLYMERASE II TRANSCRIBES SNRNA GENES%REACTOME DATABASE ID RELEASE 66%10146187 RNA polymerase II transcribes snRNA genes MRNA DECAY BY 3' TO 5' EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 66%10145639 mRNA decay by 3' to 5' exoribonuclease AMINE-DERIVED HORMONES%REACTOME%R-RNO-209776.1 Amine-derived hormones PROGRESSIVE TRIMMING OF ALPHA-1,2-LINKED MANNOSE RESIDUES FROM MAN9 8 7GLCNAC2 TO PRODUCE MAN5GLCNAC2%REACTOME%R-RNO-964827.1 Progressive trimming of alpha-1,2-linked mannose residues from Man9 8 7GlcNAc2 to produce Man5GlcNAc2 AMINO ACID AND DERIVATIVE METABOLISM%REACTOME%R-RNO-71291.1 Amino acid and derivative metabolism INOSITOL PHOSPHATE METABOLISM%REACTOME%R-RNO-1483249.1 Inositol phosphate metabolism FORMATION OF ATP BY CHEMIOSMOTIC COUPLING%REACTOME DATABASE ID RELEASE 66%10145126 Formation of ATP by chemiosmotic coupling ACTIVATION OF SMO%REACTOME DATABASE ID RELEASE 66%10146091 Activation of SMO GLI3 IS PROCESSED TO GLI3R BY THE PROTEASOME%REACTOME DATABASE ID RELEASE 66%10146075 GLI3 is processed to GLI3R by the proteasome RELEASE OF HH-NP FROM THE SECRETING CELL%REACTOME DATABASE ID RELEASE 66%10146062 Release of Hh-Np from the secreting cell ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES%REACTOME%R-RNO-2022090.1 Assembly of collagen fibrils and other multimeric structures PEROXISOMAL PROTEIN IMPORT%REACTOME DATABASE ID RELEASE 66%10146282 Peroxisomal protein import RECYCLING PATHWAY OF L1%REACTOME DATABASE ID RELEASE 66%10145501 Recycling pathway of L1 VASOPRESSIN REGULATES RENAL WATER HOMEOSTASIS VIA AQUAPORINS%REACTOME%R-RNO-432040.1 Vasopressin regulates renal water homeostasis via Aquaporins PI5P REGULATES TP53 ACETYLATION%REACTOME%R-RNO-6811555.1 PI5P Regulates TP53 Acetylation HYPUSINYLATION%REACTOME%R-RNO-204626.1 Hypusinylation UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1%REACTOME DATABASE ID RELEASE 66%10144899 Ubiquitin-dependent degradation of Cyclin D1 VEGFA-VEGFR2 PATHWAY%REACTOME DATABASE ID RELEASE 66%10145272 VEGFA-VEGFR2 Pathway TRANSCRIPTIONAL REGULATION BY RUNX3%REACTOME%R-RNO-8878159.1 Transcriptional regulation by RUNX3 TP53 REGULATES TRANSCRIPTION OF DNA REPAIR GENES%REACTOME DATABASE ID RELEASE 66%10146165 TP53 Regulates Transcription of DNA Repair Genes PI-3K CASCADE:FGFR2%REACTOME DATABASE ID RELEASE 66%10145254 PI-3K cascade:FGFR2 TRANSLESION SYNTHESIS BY REV1%REACTOME DATABASE ID RELEASE 66%10144976 Translesion synthesis by REV1 SHC1 EVENTS IN ERBB4 SIGNALING%REACTOME DATABASE ID RELEASE 66%10145825 SHC1 events in ERBB4 signaling TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM%REACTOME DATABASE ID RELEASE 66%10144896 Transport of Mature Transcript to Cytoplasm CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 66%10144717 CDT1 association with the CDC6:ORC:origin complex ACTIVATION OF BMF AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%R-RNO-139910.1 Activation of BMF and translocation to mitochondria CELL CYCLE, MITOTIC%REACTOME DATABASE ID RELEASE 66%10144721 Cell Cycle, Mitotic NEGATIVE REGULATION OF MET ACTIVITY%REACTOME%R-RNO-6807004.1 Negative regulation of MET activity MTOR SIGNALLING%REACTOME DATABASE ID RELEASE 66%10145128 mTOR signalling PURINE CATABOLISM%REACTOME%R-RNO-74259.1 Purine catabolism PHENYLALANINE AND TYROSINE CATABOLISM%REACTOME%R-RNO-71182.1 Phenylalanine and tyrosine catabolism SYNTHESIS OF DIPHTHAMIDE-EEF2%REACTOME DATABASE ID RELEASE 66%10146058 Synthesis of diphthamide-EEF2 TRIGLYCERIDE CATABOLISM%REACTOME%R-RNO-163560.1 Triglyceride catabolism CD28 CO-STIMULATION%REACTOME DATABASE ID RELEASE 66%10145354 CD28 co-stimulation REMOVAL OF AMINOTERMINAL PROPEPTIDES FROM GAMMA-CARBOXYLATED PROTEINS%REACTOME%R-RNO-159782.1 Removal of aminoterminal propeptides from gamma-carboxylated proteins EGFR TRANSACTIVATION BY GASTRIN%REACTOME%R-RNO-2179392.1 EGFR Transactivation by Gastrin GENE SILENCING BY RNA%REACTOME DATABASE ID RELEASE 66%10145435 Gene Silencing by RNA RUNX1 REGULATES GENES INVOLVED IN MEGAKARYOCYTE DIFFERENTIATION AND PLATELET FUNCTION%REACTOME%R-RNO-8936459.1 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function ONCOGENE INDUCED SENESCENCE%REACTOME DATABASE ID RELEASE 66%10145265 Oncogene Induced Senescence BIOSYNTHESIS OF MARESIN CONJUGATES IN TISSUE REGENERATION (MCTR)%REACTOME DATABASE ID RELEASE 66%10146313 Biosynthesis of maresin conjugates in tissue regeneration (MCTR) ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS%REACTOME DATABASE ID RELEASE 66%10145721 Acetylcholine binding and downstream events LIPID PARTICLE ORGANIZATION%REACTOME%R-RNO-8964572.1 Lipid particle organization TYPE I HEMIDESMOSOME ASSEMBLY%REACTOME DATABASE ID RELEASE 66%10145647 Type I hemidesmosome assembly METABOLISM OF INGESTED MESEO2H INTO MESEH%REACTOME%R-RNO-5263617.1 Metabolism of ingested MeSeO2H into MeSeH PROTEIN METHYLATION%REACTOME%R-RNO-8876725.1 Protein methylation SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE%REACTOME DATABASE ID RELEASE 66%10145901 Synthesis of PIPs at the Golgi membrane LAMININ INTERACTIONS%REACTOME DATABASE ID RELEASE 66%10145448 Laminin interactions SMAC BINDS TO IAPS%REACTOME%R-RNO-111463.1 SMAC binds to IAPs NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING%REACTOME%R-RNO-936440.1 Negative regulators of RIG-I MDA5 signaling HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM%REACTOME DATABASE ID RELEASE 66%10145731 Heparan sulfate heparin (HS-GAG) metabolism APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS%REACTOME DATABASE ID RELEASE 66%10145386 Apoptotic cleavage of cell adhesion proteins ASPARAGINE N-LINKED GLYCOSYLATION%REACTOME%R-RNO-446203.1 Asparagine N-linked glycosylation FORMATION OF FIBRIN CLOT (CLOTTING CASCADE)%REACTOME%R-RNO-140877.1 Formation of Fibrin Clot (Clotting Cascade) CD28 DEPENDENT PI3K AKT SIGNALING%REACTOME%R-RNO-389357.1 CD28 dependent PI3K Akt signaling TYSND1 CLEAVES PEROXISOMAL PROTEINS%REACTOME DATABASE ID RELEASE 66%10146324 TYSND1 cleaves peroxisomal proteins INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX%REACTOME%R-RNO-141430.1 Inactivation of APC C via direct inhibition of the APC C complex GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION%REACTOME%R-RNO-162658.1 Golgi Cisternae Pericentriolar Stack Reorganization LYSOSOME VESICLE BIOGENESIS%REACTOME%R-RNO-432720.1 Lysosome Vesicle Biogenesis PD-1 SIGNALING%REACTOME%R-RNO-389948.1 PD-1 signaling TRANSPORT OF BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS%REACTOME%R-RNO-425366.1 Transport of bile salts and organic acids, metal ions and amine compounds SIGNALLING TO RAS%REACTOME DATABASE ID RELEASE 66%10145202 Signalling to RAS ACTIVATION OF NF-KAPPAB IN B CELLS%REACTOME%R-RNO-1169091.1 Activation of NF-kappaB in B cells NUCLEOSOME ASSEMBLY%REACTOME%R-RNO-774815.1 Nucleosome assembly DDX58 IFIH1-MEDIATED INDUCTION OF INTERFERON-ALPHA BETA%REACTOME%R-RNO-168928.1 DDX58 IFIH1-mediated induction of interferon-alpha beta EGFR DOWNREGULATION%REACTOME DATABASE ID RELEASE 66%10145266 EGFR downregulation INTERLEUKIN-1 FAMILY SIGNALING%REACTOME DATABASE ID RELEASE 66%10145170 Interleukin-1 family signaling SUMOYLATION OF INTRACELLULAR RECEPTORS%REACTOME%R-RNO-4090294.1 SUMOylation of intracellular receptors RUNX3 REGULATES P14-ARF%REACTOME DATABASE ID RELEASE 66%10146279 RUNX3 regulates p14-ARF ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS%REACTOME DATABASE ID RELEASE 66%10145174 ZBP1(DAI) mediated induction of type I IFNs PROTON OLIGOPEPTIDE COTRANSPORTERS%REACTOME DATABASE ID RELEASE 66%10145629 Proton oligopeptide cotransporters METALLOPROTEASE DUBS%REACTOME DATABASE ID RELEASE 66%10146145 Metalloprotease DUBs ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION%REACTOME%R-RNO-450302.1 activated TAK1 mediates p38 MAPK activation NEGATIVE FEEDBACK REGULATION OF MAPK PATHWAY%REACTOME%R-RNO-5674499.1 Negative feedback regulation of MAPK pathway ALPHA-OXIDATION OF PHYTANATE%REACTOME DATABASE ID RELEASE 66%10145549 Alpha-oxidation of phytanate LIGAND-DEPENDENT CASPASE ACTIVATION%REACTOME DATABASE ID RELEASE 66%10144860 Ligand-dependent caspase activation PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE%REACTOME DATABASE ID RELEASE 66%10144782 Pyruvate metabolism and Citric Acid (TCA) cycle CD28 DEPENDENT VAV1 PATHWAY%REACTOME DATABASE ID RELEASE 66%10145542 CD28 dependent Vav1 pathway AMINE LIGAND-BINDING RECEPTORS%REACTOME%R-RNO-375280.1 Amine ligand-binding receptors MRNA DECAY BY 5' TO 3' EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 66%10145636 mRNA decay by 5' to 3' exoribonuclease MOLYBDENUM COFACTOR BIOSYNTHESIS%REACTOME%R-RNO-947581.1 Molybdenum cofactor biosynthesis TRANSLESION SYNTHESIS BY Y FAMILY DNA POLYMERASES BYPASSES LESIONS ON DNA TEMPLATE%REACTOME DATABASE ID RELEASE 66%10144977 Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template HISTIDINE, LYSINE, PHENYLALANINE, TYROSINE, PROLINE AND TRYPTOPHAN CATABOLISM%REACTOME DATABASE ID RELEASE 66%10144795 Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism SPERM MOTILITY AND TAXES%REACTOME%R-RNO-1300642.1 Sperm Motility And Taxes ENZYMATIC DEGRADATION OF DOPAMINE BY COMT%REACTOME DATABASE ID RELEASE 66%10145520 Enzymatic degradation of dopamine by COMT REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE%REACTOME%R-RNO-176408.1 Regulation of APC C activators between G1 S and early anaphase RNA POLYMERASE III TRANSCRIPTION%REACTOME%R-RNO-74158.1 RNA Polymerase III Transcription ACTIVATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME DATABASE ID RELEASE 66%10144871 Activation of the phototransduction cascade FERTILIZATION%REACTOME%R-RNO-1187000.1 Fertilization SIGNAL AMPLIFICATION%REACTOME%R-RNO-392518.1 Signal amplification ACTIVATED PKN1 STIMULATES TRANSCRIPTION OF AR (ANDROGEN RECEPTOR) REGULATED GENES KLK2 AND KLK3%REACTOME DATABASE ID RELEASE 66%10146086 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE%REACTOME%R-RNO-174414.1 Processive synthesis on the C-strand of the telomere IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 66%10145133 Immune System PORPHYRIN METABOLISM%REACTOME DATABASE ID RELEASE 66%10145085 Porphyrin metabolism RA BIOSYNTHESIS PATHWAY%REACTOME%R-RNO-5365859.1 RA biosynthesis pathway CLASSICAL KIR CHANNELS%REACTOME DATABASE ID RELEASE 66%10145835 Classical Kir channels REGULATION BY C-FLIP%REACTOME DATABASE ID RELEASE 66%10146009 Regulation by c-FLIP PROTEIN UBIQUITINATION%REACTOME DATABASE ID RELEASE 66%10146215 Protein ubiquitination THROMBOXANE SIGNALLING THROUGH TP RECEPTOR%REACTOME%R-RNO-428930.1 Thromboxane signalling through TP receptor APC C:CDC20 MEDIATED DEGRADATION OF SECURIN%REACTOME%R-RNO-174154.1 APC C:Cdc20 mediated degradation of Securin SHC1 EVENTS IN EGFR SIGNALING%REACTOME%R-RNO-180336.1 SHC1 events in EGFR signaling CHYLOMICRON REMODELING%REACTOME DATABASE ID RELEASE 66%10145241 Chylomicron remodeling PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA%REACTOME%R-RNO-72203.1 Processing of Capped Intron-Containing Pre-mRNA INSULIN RECEPTOR RECYCLING%REACTOME%R-RNO-77387.1 Insulin receptor recycling INTERLEUKIN-6 SIGNALING%REACTOME DATABASE ID RELEASE 66%10145796 Interleukin-6 signaling