THIO-MOLYBDENUM COFACTOR BIOSYNTHESIS%HUMANCYC%PWY-5963 thio-molybdenum cofactor biosynthesis Mocos PROLINE BIOSYNTHESIS I%HUMANCYC%PROSYN-PWY proline biosynthesis I Pycrl Pycr2 Aldh18a1 Pycr1 MOLYBDENUM COFACTOR BIOSYNTHESIS%HUMANCYC%PWY-6823 molybdenum cofactor biosynthesis Mocs3 Nfs1 Gphn Mocs2 GLYCEROL DEGRADATION I%HUMANCYC%PWY-4261 glycerol degradation I Gyk Gk5 Gk2 OXIDATIVE ETHANOL DEGRADATION III%HUMANCYC%PWY66-161 oxidative ethanol degradation III Aldh2 Acss2 Aldh3a2 Acss1 Cyp2e1 TETRAPYRROLE BIOSYNTHESIS II%HUMANCYC%PWY-5189 tetrapyrrole biosynthesis II Hmbs Alas1 Alad Uros Alas2 ASPARAGINE DEGRADATION I%HUMANCYC%ASPARAGINE-DEG1-PWY asparagine degradation I Aspg Asrgl1 TETRAHYDROBIOPTERIN BIOSYNTHESIS I%HUMANCYC%PWY-5663 tetrahydrobiopterin biosynthesis I Gch1 Pts Spr UREA CYCLE%HUMANCYC%PWY-4984 urea cycle Otc Asl Arg2 Cps1 Ass1 Arg1 4-HYDROXYPHENYLPYRUVATE BIOSYNTHESIS%HUMANCYC%PWY-5886 4-hydroxyphenylpyruvate biosynthesis Tat KETOGENESIS%HUMANCYC%REACT_1464.NULL ketogenesis Hmgcl Hadhb Bdh1 Acat1 Hmgcs2 Acaa1a CDP-DIACYLGLYCEROL BIOSYNTHESIS I%HUMANCYC%PWY-5667 CDP-diacylglycerol biosynthesis I Mboat7 Agpat1 Agpat2 Abhd5 Agpat3 Agpat4 Cds1 Gpam Lpcat3 Lpcat4 Cds2 Agpat5 Agpat6 Gpd2 Agpat9 Gpat2 Mboat2 Lclat1 SELENOCYSTEINE BIOSYNTHESIS II (ARCHAEA AND EUKARYOTES)%HUMANCYC%PWY-6281 selenocysteine biosynthesis II (archaea and eukaryotes) Sephs1 Sephs2 Sars2 Sars Sepsecs Pstk CATECHOLAMINE BIOSYNTHESIS%HUMANCYC%PWY66-301 catecholamine biosynthesis Pnmt Ddc RAPOPORT-LUEBERING GLYCOLYTIC SHUNT%HUMANCYC%PWY-6405 Rapoport-Luebering glycolytic shunt Pgam1 Pgam2 Bpgm Minpp1 L-CARNITINE BIOSYNTHESIS%HUMANCYC%PWY-6100 L-carnitine biosynthesis Tmlhe Bbox1 Aldh9a1 ASPARAGINE BIOSYNTHESIS I%HUMANCYC%ASPARAGINE-BIOSYNTHESIS asparagine biosynthesis I Asns UDP-D-XYLOSE AND UDP-D-GLUCURONATE BIOSYNTHESIS%HUMANCYC%PWY-4821 UDP-D-xylose and UDP-D-glucuronate biosynthesis Ugdh Uxs1 4-HYDROXY-2-NONENAL DETOXIFICATION%HUMANCYC%PWY-7112 4-hydroxy-2-nonenal detoxification Gm10639 Gsta3 GUANINE AND GUANOSINE SALVAGE I%HUMANCYC%PWY-6620 guanine and guanosine salvage I Pnp Hprt GDP-MANNOSE BIOSYNTHESIS%HUMANCYC%PWY-5659 GDP-mannose biosynthesis Pmm2 Gpi1 Pmm1 Mpi Gmppa Gmppb THREONINE DEGRADATION II%HUMANCYC%THREONINE-DEG2-PWY threonine degradation II Gcat SUPERPATHWAY OF D-MYO< I>-INOSITOL (1,4,5)-TRISPHOSPHATE METABOLISM%HUMANCYC%PWY-6358 superpathway of D-myo< i>-inositol (1,4,5)-trisphosphate metabolism Itpkb Inpp5f Ocrl Ipmk Itpkc Inpp5d Impa2 Impa1 Synj1 Inpp5a Itpka Inpp5b Inppl1 Pten Inpp1 Inpp5k Synj2 Impad1 Minpp1 S-ADENOSYL-L-METHIONINE BIOSYNTHESIS%HUMANCYC%SAM-PWY S-adenosyl-L-methionine biosynthesis Mat1a Mat2a Mat2b D-MYO< I>-INOSITOL (1,4,5)-TRISPHOSPHATE DEGRADATION%HUMANCYC%PWY-6363 D-myo< i>-inositol (1,4,5)-trisphosphate degradation Inpp5f Ocrl Synj2 Impad1 Impa2 Impa1 Synj1 Inpp5a Inpp5b Inppl1 Inpp1 Inpp5k MAP KINASE CASCADE%HUMANCYC%REACT_634.NULL MAP kinase cascade Ywhab GUANOSINE NUCLEOTIDES DEGRADATION III%HUMANCYC%PWY-6608 guanosine nucleotides degradation III Nt5c2 Pnp Gda Xdh ASPARTATE BIOSYNTHESIS%HUMANCYC%ASPARTATESYN-PWY aspartate biosynthesis Got1 Got1l1 Got2 XANTHINE AND XANTHOSINE SALVAGE%HUMANCYC%SALVPURINE2-PWY xanthine and xanthosine salvage Pnp GLYCINE BIOSYNTHESIS I%HUMANCYC%GLYSYN-PWY glycine biosynthesis I Shmt2 Shmt1 GALACTOSE DEGRADATION I (LELOIR PATHWAY)%HUMANCYC%PWY-6317 galactose degradation I (Leloir pathway) Galm Galt Galk1 Gale BMP SIGNALLING PATHWAY%HUMANCYC%REACT_12034.NULL BMP Signalling Pathway Bmp2 Ski Ube2d1 Smad4 Ube2d3 GDP-GLUCOSE BIOSYNTHESIS%HUMANCYC%PWY-5661 GDP-glucose biosynthesis Pgm2 Pgm5 Pgm1 Hkdc1 Gck DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE BIOSYNTHESIS%HUMANCYC%MANNOSYL-CHITO-DOLICHOL-BIOSYNTHESIS dolichyl-diphosphooligosaccharide biosynthesis Alg1 Alg3 Dpm1 Alg5 Dpagt1 Dpm3 Alg6 Alg8 GLUTATHIONE BIOSYNTHESIS%HUMANCYC%GLUTATHIONESYN-PWY glutathione biosynthesis Gclc Gss Gclm SUPEROXIDE RADICALS DEGRADATION%HUMANCYC%DETOX1-PWY superoxide radicals degradation Tyrp1 Cat Sod3 Sod2 MYO< I>-INOSITOL BIOSYNTHESIS%HUMANCYC%PWY-2301 myo< i>-inositol biosynthesis Impad1 Impa2 Impa1 Isyna1 ARGININE DEGRADATION VI (ARGINASE 2 PATHWAY)%HUMANCYC%ARG-PRO-PWY arginine degradation VI (arginase 2 pathway) Pycrl Pycr2 Arg2 Pycr1 Arg1 Oat GLYCINE BIOSYNTHESIS III%HUMANCYC%GLYSYN-ALA-PWY glycine biosynthesis III Agxt Agxt2 PYRIDOXAL 5'-PHOSPHATE SALVAGE PATHWAY%HUMANCYC%PLPSAL-PWY pyridoxal 5'-phosphate salvage pathway Pnpo Pdxk CITRULLINE-NITRIC OXIDE CYCLE%HUMANCYC%PWY-4983 citrulline-nitric oxide cycle Asl Nos1 Ass1 Nos2 Nos3 PHOSPHATIDYLGLYCEROL BIOSYNTHESIS II (NON-PLASTIDIC)%HUMANCYC%PWY4FS-8 phosphatidylglycerol biosynthesis II (non-plastidic) Mboat7 Agpat1 Agpat2 Abhd5 Agpat3 Agpat4 Pgs1 Cds1 Gpam Lpcat3 Lpcat4 Cds2 Agpat5 Agpat6 Gpd2 Agpat9 Gpat2 Mboat2 Lclat1 L-DOPA DEGRADATION%HUMANCYC%PWY-6334 L-dopa degradation Comt SALVAGE PATHWAYS OF PYRIMIDINE RIBONUCLEOTIDES%HUMANCYC%PWY0-163 salvage pathways of pyrimidine ribonucleotides Uck2 Uprt Nme6 Nme7 Upp1 Upp2 Uckl1 Uck1 Cda Nme5 Nme1 Nme3 Nme4 Aicda SULFATE ACTIVATION FOR SULFONATION%HUMANCYC%PWY-5340 sulfate activation for sulfonation Papss2 Papss1 TYROSINE DEGRADATION I%HUMANCYC%TYRFUMCAT-PWY tyrosine degradation I Tat Fah Hgd Gstz1 Hpd SPERMINE BIOSYNTHESIS%HUMANCYC%ARGSPECAT-PWY spermine biosynthesis Sms PURINE NUCLEOTIDES DE NOVO< I> BIOSYNTHESIS II%HUMANCYC%PWY-841 purine nucleotides de novo< i> biosynthesis II Adssl1 Gart Adsl Impdh1 Ppat Atic Pfas Adss Gmps Paics GLUTAMINE DEGRADATION I%HUMANCYC%GLUTAMINDEG-PWY glutamine degradation I Gls Gls2 Asns SEROTONIN DEGRADATION%HUMANCYC%PWY-6313 serotonin degradation Aldh2 Aldh3a2 Maob Maoa Ugt2b34 Sult1a1 EUMELANIN BIOSYNTHESIS%HUMANCYC%PWY-6498 eumelanin biosynthesis Dct Trpc1 Tyr Tyrp1 COLANIC ACID BUILDING BLOCKS BIOSYNTHESIS%HUMANCYC%COLANSYN-PWY colanic acid building blocks biosynthesis Galt Galk1 Tsta3 Ugp2 Gmds Ugdh Pmm2 Gpi1 Pmm1 Gale Mpi Gmppa Gmppb GLUCONEOGENESIS I%HUMANCYC%GLUCONEO-PWY gluconeogenesis I Eno3 Me1 Me3 Me2 Fbp2 Eno2 Vcan Fbp1 Eno1 Pgk2 Mdh2 Pgk1 Aldoa Pck1 Mdh1 Eno1b Gapdhs Aldob Gpi1 Pgam1 Pgam2 Bpgm D-MANNOSE DEGRADATION%HUMANCYC%MANNCAT-PWY D-mannose degradation Mpi FLAVIN BIOSYNTHESIS IV (MAMMALIAN)%HUMANCYC%11070 flavin biosynthesis IV (mammalian) Flad1 Rfk S< I>-METHYL-5-THIO-&ALPHA;-D-RIBOSE 1-PHOSPHATE DEGRADATION%HUMANCYC%PWY-6755 S< i>-methyl-5-thio-α-D-ribose 1-phosphate degradation Adi1 Mri1 Apip Enoph1 FATTY ACID &BETA;-OXIDATION III (UNSATURATED, ODD NUMBER)%HUMANCYC%PWY-5137 fatty acid β-oxidation III (unsaturated, odd number) Eci1 Ehhadh Eci2 GLYCINE DEGRADATION (CREATINE BIOSYNTHESIS)%HUMANCYC%GLYCGREAT-PWY glycine degradation (creatine biosynthesis) Gamt Gatm GLUTAMATE DEPENDENT ACID RESISTANCE%HUMANCYC%PWY0-1305 glutamate dependent acid resistance Gad1 Gad2 TRIACYLGLYCEROL BIOSYNTHESIS%HUMANCYC%TRIGLSYN-PWY triacylglycerol biosynthesis Ppapdc1a Lppr2 Lppr3 Lppr4 Ppap2b Ppap2a Mboat7 Agpat1 Agpat2 Abhd5 Dgat1 Ppap2c Agpat3 Dgat2 Mogat1 Agpat4 Gpam Lpcat3 Lpcat4 Agpat5 Agpat6 Agpat9 Gpat2 Mboat2 Lclat1 TREHALOSE DEGRADATION II (TREHALASE)%HUMANCYC%PWY0-1182 trehalose degradation II (trehalase) Galm Hkdc1 Gck Treh &ALPHA;-TOCOPHEROL DEGRADATION%HUMANCYC%PWY-6377 α-tocopherol degradation Cyp4f15 SPERMINE AND SPERMIDINE DEGRADATION I%HUMANCYC%PWY-6117 spermine and spermidine degradation I Aoc3 Sat2 Smox Paox Sat1 NAD SALVAGE PATHWAY III%HUMANCYC%PWY3O-4106 NAD salvage pathway III Nmrk2 Nmnat3 Nmnat2 Nmnat1 Nmrk1 PYRUVATE FERMENTATION TO LACTATE%HUMANCYC%PWY-5481 pyruvate fermentation to lactate Ldha Ldhc Ldhb Ldhal6b NAD BIOSYNTHESIS FROM 2-AMINO-3-CARBOXYMUCONATE SEMIALDEHYDE%HUMANCYC%PWY-5653 NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde Qprt Nadsyn1 Nmnat3 Nmnat2 Nmnat1 FATTY ACID BIOSYNTHESIS INITIATION II%HUMANCYC%PWY-5966 fatty acid biosynthesis initiation II Fasn Oxsm PUTRESCINE DEGRADATION III%HUMANCYC%PWY-0 putrescine degradation III Aldh2 Sat2 Aldh3a1 Aldh3a2 Maob Sat1 Maoa Aldh1b1 Aldh3b1 DIPHTHAMIDE BIOSYNTHESIS%HUMANCYC%PWY-6482 diphthamide biosynthesis Dph5 CHOLESTEROL BIOSYNTHESIS III (VIA DESMOSTEROL)%HUMANCYC%PWY66-4 cholesterol biosynthesis III (via desmosterol) Lbr Sqle Fdft1 Ebp Tm7sf2 Cyp51 Hsd17b7 Nsdhl Dhcr7 Lss Sc5d Dhcr24 TAURINE BIOSYNTHESIS%HUMANCYC%PWY-5331 taurine biosynthesis Cdo1 Csad TRNA SPLICING%HUMANCYC%PWY-6689 tRNA splicing Tsen34 Trpt1 Tsen54 Tsen15 Tsen2 4-AMINOBUTYRATE DEGRADATION I%HUMANCYC%PWY-6535 4-aminobutyrate degradation I Abat Aldh5a1 TETRAHYDROBIOPTERIN BIOSYNTHESIS II%HUMANCYC%PWY-5664 tetrahydrobiopterin biosynthesis II Gch1 Pts Spr NAD SALVAGE PATHWAY II%HUMANCYC%NAD-BIOSYNTHESIS-II NAD salvage pathway II Enpp3 Acp6 Enpp1 Nudt12 Nmrk2 Nmnat3 Nmnat2 Nmnat1 Nmrk1 Nt5e Nt5c3b Pxylp1 PUTRESCINE BIOSYNTHESIS III%HUMANCYC%PWY-46 putrescine biosynthesis III Azin2 Odc1 ADENOSINE NUCLEOTIDES DEGRADATION II%HUMANCYC%SALVADEHYPOX-PWY adenosine nucleotides degradation II Nt5c2 Pnp Nt5c1a Ada Nt5c3 Xdh Nt5e 4-HYDROXYBENZOATE BIOSYNTHESIS%HUMANCYC%PWY-5754-1 4-hydroxybenzoate biosynthesis Tat LYSINE DEGRADATION II%HUMANCYC%LYSINE-DEG1-PWY lysine degradation II Sccpdh Aldh7a1 Aass ZYMOSTEROL BIOSYNTHESIS%HUMANCYC%PWY-6074 zymosterol biosynthesis Lbr Tm7sf2 Cyp51 Hsd17b7 Nsdhl TRYPTOPHAN DEGRADATION III (EUKARYOTIC)%HUMANCYC%TRYPTOPHAN-DEGRADATION-1 tryptophan degradation III (eukaryotic) Acmsd Afmid Tdo2 Gcdh Hadhb Kynu Acat1 Kmo Acat2 Acaa1a Haao ADENINE AND ADENOSINE SALVAGE I%HUMANCYC%P121-PWY adenine and adenosine salvage I Aprt COENZYME A BIOSYNTHESIS%HUMANCYC%COA-PWY coenzyme A biosynthesis Ppcdc Ppcs Coasy INOSITOL PYROPHOSPHATES BIOSYNTHESIS%HUMANCYC%PWY-6369 inositol pyrophosphates biosynthesis Ip6k2 Ipmk Ppip5k1 Ippk Ip6k1 Ip6k3 Ppip5k2 D-MYO< I>-INOSITOL (1,3,4)-TRISPHOSPHATE BIOSYNTHESIS%HUMANCYC%PWY-6364 D-myo< i>-inositol (1,3,4)-trisphosphate biosynthesis Itpkb Ocrl Ipmk Itpkc Inpp5d Synj1 Inpp5a Itpka Inpp5b Inppl1 Pten Inpp5k Synj2 Minpp1 HISTIDINE DEGRADATION III%HUMANCYC%PWY-5030 histidine degradation III Mthfd1 Amdhd1 Hal Mthfd2 Ftcd Mthfd2l Uroc1 SUPERPATHWAY OF GERANYLGERANYLDIPHOSPHATE BIOSYNTHESIS I (VIA MEVALONATE)%HUMANCYC%PWY-5910 superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate) Pmvk Hmgcr Mvk Fdps Ggps1 Mvd Idi1 Hadhb Acat1 Acat2 Hmgcs2 Acaa1a L-CYSTEINE DEGRADATION II%HUMANCYC%LCYSDEG-PWY L-cysteine degradation II Cth PHOSPHATIDYLETHANOLAMINE BIOSYNTHESIS III%HUMANCYC%PWY-6273 phosphatidylethanolamine biosynthesis III Ptdss2 THIOSULFATE DISPROPORTIONATION III (RHODANESE)%HUMANCYC%PWY-5350 thiosulfate disproportionation III (rhodanese) Tst UDP-N< I>-ACETYL-D-GALACTOSAMINE BIOSYNTHESIS I%HUMANCYC%PWY-5512 UDP-N< i>-acetyl-D-galactosamine biosynthesis I Gale L-CYSTEINE DEGRADATION III%HUMANCYC%PWY-5329 L-cysteine degradation III Mpst GLUTATHIONE-MEDIATED DETOXIFICATION I%HUMANCYC%PWY-4061 glutathione-mediated detoxification I Gm10639 Gsta3 Gstm5 Gstt1 Gstm7 Anpep Mgst2 Mgst1 Mgst3 Ggt1 Gstm4 Ggt7 Gsto2 Gstk1 Gstm1 Ggt6 Gstz1 Gstm2 PHOSPHOLIPASES%HUMANCYC%LIPASYN-PWY phospholipases Pla2g10 Plce1 Plcg2 Plcg1 Plcd4 Plcd3 Plcz1 Pla2g4a Plch2 Pla2g4f Pla2g6 Plcd1 Pla2g2e Pla2g2d Pla2g2f Plcb2 Plcb1 Pla2g12a Oc90 Pld1 Pla2g1b Pld3 Pld2 Pnpla8 Pla2g16 Plb1 Pld4 Pla2g3 Plcb3 Plch1 Pla2g4c Plcb4 Pla2g4d Pla2g4e Pla2g5 SUPERPATHWAY OF CHOLESTEROL BIOSYNTHESIS%HUMANCYC%PWY66-5 superpathway of cholesterol biosynthesis Dhcr7 Acat2 Lbr Sqle Fdft1 Pmvk Ebp Tm7sf2 Hmgcr Cyp51 Mvk Hsd17b7 Fdps Nsdhl Ggps1 Mvd Idi1 Hadhb Lss Acat1 Hmgcs2 Sc5d Acaa1a Dhcr24 CHONDROITIN SULFATE DEGRADATION (METAZOA)%HUMANCYC%PWY-6573 chondroitin sulfate degradation (metazoa) Galns Hyal1 Arsb Hexa Hyal5 Hyal4 ACETYL-COA BIOSYNTHESIS III (FROM CITRATE)%HUMANCYC%PWY-5172 acetyl-CoA biosynthesis III (from citrate) Acly DOLICHOL AND DOLICHYL PHOSPHATE BIOSYNTHESIS%HUMANCYC%PWY-6129 dolichol and dolichyl phosphate biosynthesis Dolk Dhdds Srd5a3 TRYPTOPHAN DEGRADATION TO 2-AMINO-3-CARBOXYMUCONATE SEMIALDEHYDE%HUMANCYC%PWY-5651 tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde Afmid Tdo2 Kynu Kmo Haao ACYL-COA HYDROLYSIS%HUMANCYC%PWY-5148 acyl-CoA hydrolysis Acot8 Acot7 Acot9 STEARATE BIOSYNTHESIS I (ANIMALS)%HUMANCYC%PWY-5972 stearate biosynthesis I (animals) Slc27a2 Acsbg1 Acsl5 Acsl4 Acsl3 Elovl1 Acot4 Acot3 Acsbg2 Acsl1 Acot7 Acot2 Elovl6 DOPAMINE DEGRADATION%HUMANCYC%PWY6666-2 dopamine degradation Comt Aldh3a2 Maob Maoa Sult1a1 SUPERPATHWAY OF INOSITOL PHOSPHATE COMPOUNDS%HUMANCYC%PWY-6371 superpathway of inositol phosphate compounds Itpkb Ocrl Ipmk Itpkc Inpp5d Synj1 Inpp5a Plce1 Plcg2 Itpka Plcg1 Inpp5b Inppl1 Pten Inpp5k Synj2 Plcd4 Plcd3 Plcz1 Plch2 Plcd1 Plcb2 Plcb1 Plcb3 Plch1 Plcb4 Pik3cb Pik3cd Ip6k2 Ppip5k1 Ippk Ip6k1 Ip6k3 Ppip5k2 Minpp1 Pi4ka Pik3c2g Pik3r5 Pi4kb Sacm1l Pik3c2b Pik3c2a Pik3r2 Pik3r1 Pik3c3 Pi4k2b Pik3r3 Pik3r6 Mtmr3 Pik3r4 Pikfyve Fig4 Pik3ca Pip5kl1 Tmem55a Tmem55b Pip4k2b Pip4k2c Cdipt Itpk1 Mtmr14 Pik3cg Pip5k1c Pip5k1b Pi4k2a Pip5k1a METHYLTHIOPROPIONATE BIOSYNTHESIS%HUMANCYC%PWY-5389 methylthiopropionate biosynthesis Adi1 URACIL DEGRADATION II (REDUCTIVE)%HUMANCYC%PWY-3982 uracil degradation II (reductive) Dpysl3 Dpysl5 Dpysl2 Dpysl4 Dpys Dpyd Upb1 Crmp1 1D-MYO< I>-INOSITOL HEXAKISPHOSPHATE BIOSYNTHESIS V (FROM INS(1,3,4)P3)%HUMANCYC%PWY-6554 1D-myo< i>-inositol hexakisphosphate biosynthesis V (from Ins(1,3,4)P3) Ipmk Ippk Itpk1 S< I>-METHYL-5'-THIOADENOSINE DEGRADATION II%HUMANCYC%PWY-6756 S< i>-methyl-5'-thioadenosine degradation II Mtap TRIACYLGLYCEROL DEGRADATION%HUMANCYC%LIPAS-PWY triacylglycerol degradation Pnliprp2 Pnpla3 Pnlip Lipg Cel Mgll Abhd12 Abhd6 Lipc Pnpla2 Lipf Lipe GLYCEROL-3-PHOSPHATE SHUTTLE%HUMANCYC%PWY-6118 glycerol-3-phosphate shuttle Gpd2 Gpd1 PHOSPHATIDYLCHOLINE BIOSYNTHESIS I%HUMANCYC%PWY3O-450 phosphatidylcholine biosynthesis I Chkb Pcyt1a Chka Pcyt1b Cept1 Chpt1 GLUTARYL-COA DEGRADATION%HUMANCYC%PWY-5177 glutaryl-CoA degradation Gcdh Hadhb Acat1 Acat2 Acaa1a TRANS, TRANS< I>-FARNESYL DIPHOSPHATE BIOSYNTHESIS%HUMANCYC%PWY-5123 trans, trans< i>-farnesyl diphosphate biosynthesis Fdps Ggps1 Idi1 GLUTAMATE REMOVAL FROM FOLATES%HUMANCYC%PWY-2161B glutamate removal from folates ACYL CARRIER PROTEIN METABOLISM%HUMANCYC%PWY-6012 acyl carrier protein metabolism Aasdhppt GERANYLGERANYLDIPHOSPHATE BIOSYNTHESIS%HUMANCYC%PWY-5120 geranylgeranyldiphosphate biosynthesis Ggps1 1D-MYO< I>-INOSITOL HEXAKISPHOSPHATE BIOSYNTHESIS II (MAMMALIAN)%HUMANCYC%PWY-6362 1D-myo< i>-inositol hexakisphosphate biosynthesis II (mammalian) Itpkb Ocrl Ipmk Itpkc Inpp5d Synj1 Inpp5a Itpka Inpp5b Inppl1 Inpp5k Synj2 Ippk Itpk1 CHOLESTEROL BIOSYNTHESIS I%HUMANCYC%PWY66-341 cholesterol biosynthesis I Lbr Sqle Fdft1 Ebp Tm7sf2 Cyp51 Hsd17b7 Nsdhl Dhcr7 Lss Sc5d Dhcr24 ALANINE BIOSYNTHESIS II%HUMANCYC%ALANINE-SYN2-PWY alanine biosynthesis II Gpt2 Gpt FATTY ACID &ALPHA;-OXIDATION II%HUMANCYC%PWY66-387 fatty acid α-oxidation II Slc27a2 Acsbg1 Acsl5 Acsl4 Acsl3 Phyh Acsl6 Hacl1 Acsbg2 Acsl1 GLUTAMINE BIOSYNTHESIS I%HUMANCYC%GLNSYN-PWY glutamine biosynthesis I Glul PHENYLETHYLAMINE DEGRADATION I%HUMANCYC%2PHENDEG-PWY phenylethylamine degradation I Aoc3 Aldh2 Aldh3a2 Aoc2 MEVALONATE PATHWAY I%HUMANCYC%PWY-922 mevalonate pathway I Pmvk Hmgcr Mvk Mvd Idi1 Hadhb Acat1 Acat2 Hmgcs2 Acaa1a SPHINGOMYELIN METABOLISM%HUMANCYC%PWY3DJ-11281 sphingomyelin metabolism Smpd3 Smpd2 Sgms1 Smpd1 Samd8 Sgms2 Enpp7 Smpd4 CYSTEINE BIOSYNTHESIS HOMOCYSTEINE DEGRADATION%HUMANCYC%HOMOCYSDEGR-PWY cysteine biosynthesis homocysteine degradation Cth Cbs GDP-L-FUCOSE BIOSYNTHESIS I (FROM GDP-D-MANNOSE)%HUMANCYC%PWY-66 GDP-L-fucose biosynthesis I (from GDP-D-mannose) Tsta3 Gmds SUPERPATHWAY OF SERINE AND GLYCINE BIOSYNTHESIS I%HUMANCYC%SER-GLYSYN-PWY superpathway of serine and glycine biosynthesis I Phgdh Shmt2 Psat1 Shmt1 Psph 5-AMINOIMIDAZOLE RIBONUCLEOTIDE BIOSYNTHESIS I%HUMANCYC%PWY-6121 5-aminoimidazole ribonucleotide biosynthesis I Gart Ppat Pfas GDP-L-FUCOSE BIOSYNTHESIS II (FROM L-FUCOSE)%HUMANCYC%PWY-6 GDP-L-fucose biosynthesis II (from L-fucose) Fuk Fpgt N< I>-ACETYLGLUCOSAMINE DEGRADATION I%HUMANCYC%GLUAMCAT-PWY N< i>-acetylglucosamine degradation I Gnpda2 Amdhd2 Gnpda1 D-MYO< I>-INOSITOL (1,4,5,6)-TETRAKISPHOSPHATE BIOSYNTHESIS%HUMANCYC%PWY-6366 D-myo< i>-inositol (1,4,5,6)-tetrakisphosphate biosynthesis Ipmk Itpk1 Minpp1 UDP-N< I>-ACETYL-D-GALACTOSAMINE BIOSYNTHESIS II%HUMANCYC%PWY-5514 UDP-N< i>-acetyl-D-galactosamine biosynthesis II Gnpda2 Gnpda1 Gpi1 Gale Uap1 Hkdc1 Gck Gnpnat1 Pgm3 2-AMINO-3-CARBOXYMUCONATE SEMIALDEHYDE DEGRADATION TO GLUTARYL-COA%HUMANCYC%PWY-5652 2-amino-3-carboxymuconate semialdehyde degradation to glutaryl-CoA Acmsd L-SERINE DEGRADATION%HUMANCYC%SERDEG-PWY L-serine degradation Sds Sdsl ACETATE CONVERSION TO ACETYL-COA%HUMANCYC%PWY0-1313 acetate conversion to acetyl-CoA Acss2 Acss1 THYROID HORMONE BIOSYNTHESIS%HUMANCYC%PWY-6241 thyroid hormone biosynthesis Tpo Ctsd ANDROGEN BIOSYNTHESIS%HUMANCYC%PWY66-378 androgen biosynthesis Hsd3b1 Cyp17a1 Srd5a1 Hsd17b3 Srd5a2 Akr1c18 Hsd3b6 FOLATE POLYGLUTAMYLATION%HUMANCYC%PWY-2161 folate polyglutamylation Fpgs Mthfd1 Mthfd1l Shmt2 Shmt1 CHOLINE BIOSYNTHESIS III%HUMANCYC%PWY-3561 choline biosynthesis III Pld1 Pld3 Pld2 Pcyt1a Pld4 Pcyt1b Cept1 Chpt1 INOSINE-5'-PHOSPHATE BIOSYNTHESIS II%HUMANCYC%PWY-6124 inosine-5'-phosphate biosynthesis II Adsl Atic Paics DERMATAN SULFATE BIOSYNTHESIS (LATE STAGES)%HUMANCYC%PWY-6568 dermatan sulfate biosynthesis (late stages) Ust Chst15 Chst14 Dse URATE BIOSYNTHESIS INOSINE 5'-PHOSPHATE DEGRADATION%HUMANCYC%PWY-5695 urate biosynthesis inosine 5'-phosphate degradation Nt5c2 Pnp Xdh Impdh1 Nt5e Nt5c3b URIDINE-5'-PHOSPHATE BIOSYNTHESIS%HUMANCYC%PWY-5686 uridine-5'-phosphate biosynthesis Umps Cad METHYLGLYOXAL DEGRADATION III%HUMANCYC%PWY-5453 methylglyoxal degradation III Akr1b3 Akr1b10 Cyp2e1 PURINE NUCLEOTIDES DEGRADATION II (AEROBIC)%HUMANCYC%PWY-6353 purine nucleotides degradation II (aerobic) Nt5c2 Pnp Nt5c1a Ada Nt5c3 Gda Xdh Impdh1 Nt5e Nt5c3b FATTY ACID ACTIVATION%HUMANCYC%PWY-5143 fatty acid activation Slc27a2 Acsbg1 Acsl5 Acsl4 Acsl3 Acsl6 Acsbg2 Acsl1 CERAMIDE DEGRADATION%HUMANCYC%PWY-6483 ceramide degradation Asah2 SALVAGE PATHWAYS OF PYRIMIDINE DEOXYRIBONUCLEOTIDES%HUMANCYC%PWY0-181 salvage pathways of pyrimidine deoxyribonucleotides Cda Aicda Tk1 Tk2 Tymp 3-PHOSPHOINOSITIDE BIOSYNTHESIS%HUMANCYC%PWY-6352 3-phosphoinositide biosynthesis Pik3cb Pik3cd Pi4ka Pik3c2g Pik3r5 Pi4kb Sacm1l Pik3c2b Pik3c2a Pik3r2 Pik3r1 Pik3c3 Pi4k2b Pik3r3 Pik3r6 Pik3r4 Pikfyve Fig4 Pik3ca Pip5kl1 Pip4k2b Cdipt Pik3cg Pip5k1c Pip5k1b Pi4k2a Pip5k1a SPERMIDINE BIOSYNTHESIS I%HUMANCYC%BSUBPOLYAMSYN-PWY spermidine biosynthesis I Srm ADENINE AND ADENOSINE SALVAGE III%HUMANCYC%PWY-6609 adenine and adenosine salvage III Pnp Hprt Ada PROTEIN CITRULLINATION%HUMANCYC%PWY-4921 protein citrullination Padi6 Padi1 Padi4 Padi3 Padi2 NAD BIOSYNTHESIS II (FROM TRYPTOPHAN)%HUMANCYC%NADSYN-PWY NAD biosynthesis II (from tryptophan) Qprt Afmid Tdo2 Nadsyn1 Nmnat3 Nmnat2 Nmnat1 Kynu Kmo Haao PENTOSE PHOSPHATE PATHWAY%HUMANCYC%PENTOSE-P-PWY pentose phosphate pathway Tkt G6pdx Pgls Rpia Taldo1 Tktl2 Tktl1 H6pd Rpe Pgd PROLINE BIOSYNTHESIS II (FROM ARGININE)%HUMANCYC%PWY-4981 proline biosynthesis II (from arginine) Otc Pycrl Pycr2 Pycr1 Oat D-MYO< I>-INOSITOL (1,4,5)-TRISPHOSPHATE BIOSYNTHESIS%HUMANCYC%PWY-6351 D-myo< i>-inositol (1,4,5)-trisphosphate biosynthesis Pi4ka Plcd4 Plcd3 Plcz1 Pi4kb Plch2 Plcd1 Plce1 Plcg2 Pi4k2b Plcg1 Plcb2 Plcb1 Pip5kl1 Pip4k2b Pip4k2c Cdipt Plcb3 Plch1 Plcb4 Pip5k1c Pip5k1b Pi4k2a Pip5k1a GLUTAMATE DEGRADATION II%HUMANCYC%GLUTDEG-PWY glutamate degradation II Got1 Got1l1 Got2 PENTOSE PHOSPHATE PATHWAY (OXIDATIVE BRANCH)%HUMANCYC%OXIDATIVEPENT-PWY pentose phosphate pathway (oxidative branch) G6pdx Pgls H6pd Pgd KETOLYSIS%HUMANCYC%REACT_59.NULL ketolysis Oxct1 Bdh2 Hadhb Bdh1 Acat1 Acaa1a SPHINGOSINE AND SPHINGOSINE-1-PHOSPHATE METABOLISM%HUMANCYC%PWY3DJ-11470 sphingosine and sphingosine-1-phosphate metabolism Sgpp2 Sgpp1 Sphk1 Sphk2 Asah2 Acer1 Ptgr1 Acer2 Asah1 HEME BIOSYNTHESIS II%HUMANCYC%PWY-5920 heme biosynthesis II Hmbs Alas1 Alad Uros Cpox Fech Ppox Urod Alas2 HEME BIOSYNTHESIS FROM UROPORPHYRINOGEN-III I%HUMANCYC%HEME-BIOSYNTHESIS-II heme biosynthesis from uroporphyrinogen-III I Cpox Fech Ppox Urod TYROSINE BIOSYNTHESIS IV%HUMANCYC%PWY-6134 tyrosine biosynthesis IV Pah CMP-N< I>-ACETYLNEURAMINATE BIOSYNTHESIS I (EUKARYOTES)%HUMANCYC%PWY-6138 CMP-N< i>-acetylneuraminate biosynthesis I (eukaryotes) Gne Cmas Nanp Nans FATTY ACID &BETA;-OXIDATION I%HUMANCYC%FAO-PWY fatty acid β-oxidation I Echs1 Slc27a2 Hadha Acsbg1 Hadh Acsl5 Acsl4 Hsd17b10 Acsl3 Acsl6 Acaa2 Acsbg2 Acsl1 Hadhb Eci1 Ehhadh Acaa1a Eci2 ARGININE BIOSYNTHESIS IV%HUMANCYC%ARGININE-SYN4-PWY arginine biosynthesis IV Otc Asl Ass1 Glud1 Oat NORADRENALINE AND ADRENALINE DEGRADATION%HUMANCYC%PWY-6342 noradrenaline and adrenaline degradation Aldh2 Comt Aldh3a2 Pnmt Maob Maoa Tomt Adh4 CARDIOLIPIN BIOSYNTHESIS II%HUMANCYC%PWY-5269 cardiolipin biosynthesis II Crls1 Pgs1 SERINE BIOSYNTHESIS%HUMANCYC%SERSYN-PWY serine biosynthesis Phgdh Psat1 Psph SEROTONIN AND MELATONIN BIOSYNTHESIS%HUMANCYC%PWY-6030 serotonin and melatonin biosynthesis Tph1 Aanat Tph2 Ddc ETHANOL DEGRADATION II%HUMANCYC%PWY66-21 ethanol degradation II Aldh2 Acss2 Aldh3a2 Acss1 D-GLUCURONATE DEGRADATION I%HUMANCYC%PWY-5525 D-glucuronate degradation I Dcxr Cryl1 METHYLGLYOXAL DEGRADATION I%HUMANCYC%PWY-5386 methylglyoxal degradation I Glo1 Ldhd Hagh L-CYSTEINE DEGRADATION I%HUMANCYC%CYSTEINE-DEG-PWY L-cysteine degradation I Got1 Cdo1 N< I>-ACETYLGLUCOSAMINE DEGRADATION II%HUMANCYC%PWY-6517 N< i>-acetylglucosamine degradation II Gnpda2 Nagk Amdhd2 Gnpda1 METHYLMALONYL PATHWAY%HUMANCYC%PROPIONMET-PWY methylmalonyl pathway Mcee Mut Pccb Pcca GLUTATHIONE REDOX REACTIONS I%HUMANCYC%PWY-4081 glutathione redox reactions I Gpx8 Gpx7 Gpx6 Gpx1 Gpx2 Gsr Gpx3 Gpx4 Gpx5 (S)-RETICULINE BIOSYNTHESIS II%HUMANCYC%PWY-6133 (S)-reticuline biosynthesis II Tyr CITRULLINE DEGRADATION%HUMANCYC%CITRULLINE-DEG-PWY citrulline degradation Otc LACTOSE DEGRADATION III%HUMANCYC%BGALACT-PWY lactose degradation III Glb1 GLUTAMATE DEGRADATION X%HUMANCYC%PWY-5766 glutamate degradation X Glud1 L-DOPACHROME BIOSYNTHESIS%HUMANCYC%PWY-6481 L-dopachrome biosynthesis Tyr PRPP BIOSYNTHESIS I%HUMANCYC%PWY0-662 PRPP biosynthesis I Prps1l1 Prps2 Prps1 SORBITOL DEGRADATION I%HUMANCYC%PWY-4101 sorbitol degradation I Sord 1,25-DIHYDROXYVITAMIN D3< SUB> BIOSYNTHESIS%HUMANCYC%PWY-6076 1,25-dihydroxyvitamin D3< sub> biosynthesis Cyp27b1 Por Cyp2r1 CERAMIDE BIOSYNTHESIS%HUMANCYC%PWY3DJ-12 ceramide biosynthesis Sptlc1 Sptlc2 Sptlc3 Degs2 Kdsr ANANDAMIDE DEGRADATION%HUMANCYC%PWY6666-1 anandamide degradation Faah L-GLUTAMINE BIOSYNTHESIS II (TRNA-DEPENDENT)%HUMANCYC%PWY-5921 L-glutamine biosynthesis II (tRNA-dependent) Qrsl1 Gatb HISTAMINE BIOSYNTHESIS%HUMANCYC%PWY-6173 histamine biosynthesis Hdc PYRIMIDINE RIBONUCLEOTIDES INTERCONVERSION%HUMANCYC%PWY-5687 pyrimidine ribonucleotides interconversion Nme5 Nme1 Nme3 Nme4 Nme6 Cant1 Nme7 Ctps Cmpk2 Cmpk1 Ctps2 UDP-N< I>-ACETYL-D-GLUCOSAMINE BIOSYNTHESIS II%HUMANCYC%UDPNACETYLGALSYN-PWY UDP-N< i>-acetyl-D-glucosamine biosynthesis II Gfpt2 Gfpt1 Uap1 Gnpnat1 Pgm3 TRYPTOPHAN DEGRADATION X (MAMMALIAN, VIA TRYPTAMINE)%HUMANCYC%PWY-6307 tryptophan degradation X (mammalian, via tryptamine) Aldh3a2 Akr1a1 Maob Ddc Maoa DERMATAN SULFATE DEGRADATION (METAZOA)%HUMANCYC%PWY-6576 dermatan sulfate degradation (metazoa) Hyal1 Hexa Hyal5 Idua ALL-TRANS< I>-DECAPRENYL DIPHOSPHATE BIOSYNTHESIS%HUMANCYC%PWY-5806 all-trans< i>-decaprenyl diphosphate biosynthesis Pdss1 Pdss2 THYMINE DEGRADATION%HUMANCYC%PWY-6430 thymine degradation Dpysl3 Dpysl5 Dpysl2 Dpysl4 Dpys Dpyd Upb1 Crmp1 ALANINE BIOSYNTHESIS III%HUMANCYC%PWY0-1021 alanine biosynthesis III Nfs1 LANOSTEROL BIOSYNTHESIS%HUMANCYC%PWY-6132 lanosterol biosynthesis Lss PYRIMIDINE RIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%HUMANCYC%PWY0-162 pyrimidine ribonucleotides de novo< i> biosynthesis Umps Cad Cant1 Nme6 Ctps Nme7 Cmpk2 Cmpk1 Ctps2 Nme5 Nme1 Nme3 Nme4 GLUCOSE AND GLUCOSE-1-PHOSPHATE DEGRADATION%HUMANCYC%GLUCOSE1PMETAB-PWY glucose and glucose-1-phosphate degradation Pgm2 Pgm5 Pgm1 Hkdc1 Gck OLEATE BIOSYNTHESIS II (ANIMALS)%HUMANCYC%PWY-5996 oleate biosynthesis II (animals) Fads1 Scd1 Fads2 Fads6 Acot4 Acot3 Acot2 PHOSPHATIDYLETHANOLAMINE BIOSYNTHESIS II%HUMANCYC%PWY4FS-6 phosphatidylethanolamine biosynthesis II Chkb Etnk1 Cept1 Pcyt2 Ept1 PHENYLALANINE DEGRADATION I (AEROBIC)%HUMANCYC%PHENYLALANINE-DEG1-PWY phenylalanine degradation I (aerobic) Pcbd2 Pah Qdpr Pcbd1 CALCIUM TRANSPORT I%HUMANCYC%PWY-6166 calcium transport I Atp2c1 Atp2a1 Atp2c2 Atp2a3 Atp2a2 PURINE RIBONUCLEOSIDES DEGRADATION TO RIBOSE-1-PHOSPHATE%HUMANCYC%PWY0-1296 purine ribonucleosides degradation to ribose-1-phosphate Pnp Ada 4-HYDROXYPROLINE DEGRADATION I%HUMANCYC%HYDROXYPRODEG-PWY 4-hydroxyproline degradation I Aldh4a1 ASPARTATE DEGRADATION II%HUMANCYC%MALATE-ASPARTATE-SHUTTLE-PWY aspartate degradation II Mdh1 Got1 Got1l1 Got2 Mdh2 GLUTAMATE BIOSYNTHESIS II%HUMANCYC%GLUTAMATE-SYN2-PWY glutamate biosynthesis II Glud1 CHOLESTEROL BIOSYNTHESIS II (VIA 24,25-DIHYDROLANOSTEROL)%HUMANCYC%PWY66-3 cholesterol biosynthesis II (via 24,25-dihydrolanosterol) Lbr Sqle Fdft1 Ebp Tm7sf2 Cyp51 Hsd17b7 Nsdhl Dhcr7 Lss Sc5d Dhcr24 GLUTAMATE DEGRADATION III (VIA 4-AMINOBUTYRATE)%HUMANCYC%GLUDEG-I-PWY glutamate degradation III (via 4-aminobutyrate) Gad1 Abat Gad2 Aldh5a1 GLYCOGEN DEGRADATION III%HUMANCYC%PWY-5767 glycogen degradation III Pygm Pgm2 Pygl Pgm5 Gaa Pgm1 Pygb Agl Mgam ETHANOL DEGRADATION IV%HUMANCYC%PWY66-162 ethanol degradation IV Aldh2 Acss2 Aldh3a2 Acss1 Tyrp1 Cat TETRAHYDROFOLATE SALVAGE FROM 5,10-METHENYLTETRAHYDROFOLATE%HUMANCYC%PWY-6613 tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate Mthfd1 Mthfd2 Gart Mthfd2l EPOXYSQUALENE BIOSYNTHESIS%HUMANCYC%PWY-5670 epoxysqualene biosynthesis Sqle Fdft1 NAD PHOSPHORYLATION AND DEPHOSPHORYLATION%HUMANCYC%NADPHOS-DEPHOS-PWY NAD phosphorylation and dephosphorylation Acp6 Nnt Pxylp1 Nadk CREATINE-PHOSPHATE BIOSYNTHESIS%HUMANCYC%PWY-6158 creatine-phosphate biosynthesis Ckmt2 Ckmt1 Ckm Ckb ADENINE AND ADENOSINE SALVAGE VI%HUMANCYC%PWY-6619 adenine and adenosine salvage VI Adk D-MYO< I>-INOSITOL-5-PHOSPHATE METABOLISM%HUMANCYC%PWY-6367 D-myo< i>-inositol-5-phosphate metabolism Plcd4 Plcd3 Plcz1 Plch2 Plcd1 Plce1 Plcg2 Plcg1 Plcb2 Plcb1 Mtmr3 Tmem55a Tmem55b Pip4k2c Plcb3 Plch1 Mtmr14 Plcb4 PENTOSE PHOSPHATE PATHWAY (NON-OXIDATIVE BRANCH)%HUMANCYC%NONOXIPENT-PWY pentose phosphate pathway (non-oxidative branch) Tkt Rpia Taldo1 Tktl2 Tktl1 Rpe SULFITE OXIDATION IV%HUMANCYC%PWY-5326 sulfite oxidation IV Suox NAD BIOSYNTHESIS III%HUMANCYC%NAD-BIOSYNTHESIS-III NAD biosynthesis III Nampt Nmnat3 Nmnat2 Nmnat1 METHYLGLYOXAL DEGRADATION VI%HUMANCYC%MGLDLCTANA-PWY methylglyoxal degradation VI Ldhd &GAMMA;-GLUTAMYL CYCLE%HUMANCYC%PWY-4041 γ-glutamyl cycle Gclc Gss Oplah Gclm Anpep Cndp2 Ggt1 Ggt7 Dpp8 Ggt6 LEUKOTRIENE BIOSYNTHESIS%HUMANCYC%15354 leukotriene biosynthesis Ltc4s Dpep2 Alox5 Lta4h Dpep1 FORMALDEHYDE OXIDATION II (GLUTATHIONE-DEPENDENT)%HUMANCYC%PWY-1801 formaldehyde oxidation II (glutathione-dependent) Esd Adh5 NADH REPAIR%HUMANCYC%PWY-6938 NADH repair Apoa1bp SUCROSE DEGRADATION V (MAMMALIAN)%HUMANCYC%PWY66-373 sucrose degradation V (mammalian) Aldoa Galm Aldob Sis Tpi1 Khk 2-OXOBUTANOATE DEGRADATION I%HUMANCYC%PWY-5130 2-oxobutanoate degradation I Mcee Mut Pccb Pcca Bckdhb Bckdha Dld Dbt 3-PHOSPHOINOSITIDE DEGRADATION%HUMANCYC%PWY-6368 3-phosphoinositide degradation Inpp5f Ocrl Sacm1l Inpp5d Inpp5e Synj1 Tpte Inpp4a Inpp5b Inpp4b Inppl1 Pten Mtmr3 Inpp5k Synj2 Tmem55a Tmem55b Mtmr14 DTMP DE NOVO< I> BIOSYNTHESIS%HUMANCYC%PWY66-385 dTMP de novo< i> biosynthesis Dhfr Tyms Shmt2 Shmt1 ARGININE DEGRADATION I (ARGINASE PATHWAY)%HUMANCYC%ARGASEDEG-PWY arginine degradation I (arginase pathway) Arg2 Arg1 Oat Aldh4a1 MITOCHONDRIAL L-CARNITINE SHUTTLE PATHWAY%HUMANCYC%PWY-6111 mitochondrial L-carnitine shuttle pathway Cpt1c Cpt2 Cpt1a &BETA;-ALANINE DEGRADATION I%HUMANCYC%BETA-ALA-DEGRADATION-I-PWY β-alanine degradation I Abat Aldh6a1 ALANINE DEGRADATION III%HUMANCYC%ALANINE-DEG3-PWY alanine degradation III Gpt2 Gpt GLYCOGEN DEGRADATION II%HUMANCYC%PWY-5941 glycogen degradation II Pygm Pgm2 Pygl Pgm5 Pgm1 Pygb Agl D-MYO< I>-INOSITOL (3,4,5,6)-TETRAKISPHOSPHATE BIOSYNTHESIS%HUMANCYC%PWY-6365 D-myo< i>-inositol (3,4,5,6)-tetrakisphosphate biosynthesis Ipmk Itpk1 THIAMIN SALVAGE III%HUMANCYC%PWY-6898 thiamin salvage III Tpk1 HISTAMINE DEGRADATION%HUMANCYC%PWY-6181 histamine degradation Aoc2 Hnmt Aoc1 FATTY ACID &ALPHA;-OXIDATION III%HUMANCYC%PWY66-388 fatty acid α-oxidation III Aldh3a2 Hacl1 GLYCOLYSIS I%HUMANCYC%GLYCOLYSIS glycolysis I Eno3 Fbp2 Eno2 Vcan Fbp1 Eno1 Pgk2 Pgk1 Aldoa Eno1b Gapdhs Aldob Gpi1 Pfkl Pgam1 Tpi1 Pgam2 Pklr Bpgm Pfkp Pfkm Pkm OXIDIZED GTP AND DGTP DETOXIFICATION%HUMANCYC%PWY-6502 oxidized GTP and dGTP detoxification Nudt1 TRNA CHARGING%HUMANCYC%TRNA-CHARGING-PWY tRNA charging Fars2 Nars Iars2 Yars2 Farsa Farsb Lars Rars Mars Wars2 Gars Pars2 Dars Hars2 Aars2 Aars Ears2 Sars2 Sars Tarsl2 Rars2 Tars2 Iars Wars Yars Cars Kars Mars2 Vars Qars Cars2 Nars2 Hars Tars Eprs Dars2 Lars2 ALPHA6BETA4INTEGRIN%IOB%ALPHA6BETA4INTEGRIN Alpha6Beta4Integrin Pak1 Ar Casp3 Pik3ca Lamb3 Lamb2 Plec Mst1r Prkcd Fyn Ephb2 Prkca Lama3 Met Lama1 Abl1 Ntn1 Col17a1 Lama2 Egfr Pik3r2 Lama5 Pik3r3 Pik3r1 Mtor Erbb2ip Mylk3 Smad2 Eif4ebp1 Smad3 Itga6 Vim Pik3cb Ptpn11 Ywhae Shc1 Pik3cd Eif4e Rhoa Clca2 Grb2 Pik3cg Itgb4 Dsp Ywhab Clca1 Rtkn Lamc1 Lamc2 Akt1 Trp73 Irs2 Yes1 Irs1 Ptk2 Ywhaz Rac1 Ywhah Lamb1 Bad Eif6 Erbb2 Rpsa Cd151 Src Sfn TRAIL%IOB%TRAIL TRAIL Mapk3 Parp1 Casp3 Xiap Mapk1 Mapk8 Mapk9 Tnfrsf10b Nfkb1 Tnfrsf11b Bcl10 Jun Diablo Dap3 Casp1 Atm Ikbkg Ctnnb1 Casp8 Bak1 Casp7 Creb1 Aifm1 Prkdc Apaf1 Vdac1 Mapk14 Bax Tnfsf10 Casp2 Akt1 Tradd Nfkbia Mcl1 Bid H2afx Traf2 Src Fadd Ngfrap1 Irf5 Ripk1 Rela Map3k7 Cbl Cflar Chek2 Prkaa1 Ctsb LEPTIN%IOB%LEPTIN Leptin Mapk3 Mapk1 Nfkb1 Prkcd Sp1 Raf1 Pde3a Egfr Jak3 Jak2 Pik3r2 Elk1 Pdia3 Prkcz Pik3r1 Lepr Itgav Ncoa3 Hspb1 Mapk14 Gsk3a Ptpn11 Atf2 Stat5b Sh2b1 Stat1 Socs7 Rps6ka2 Slc2a4 Itgb5 Cfl2 Map2k1 Map2k2 Grb2 Khdrbs1 Th Lep Mapkapk2 Pten Map2k6 Gsk3b Map2k3 Akt1 Irs2 Irs1 Ptk2 Prkce Stat3 IFN-ALPHA%IOB%IFN-ALPHA IFN-alpha Prkcd Mtor Mapk14 Eif4ebp1 Stat5a Nfkbia Rps6ka5 Stat5b Stat1 Crkl Vav1 Pla2g4a Zap70 Prkcq Stat6 Ifnar2 Stat4 Map2k4 Tyk2 Crk Erbb3 Cbl Jak1 Map2k6 Map2k3 Akt1 Irs2 Irs1 Stat2 Ifnar1 Foxo1 Stat3 Eif4b NGF%IOB%NGF NGF Mapk3 Ptpn11 Sh2b1 Mapk1 Shc1 Plcg1 Map2k1 Dnaja3 Map2k2 Ntrk1 Irak1 Sp1 Gab1 Elk1 Frs2 Creb1 Rps6ka1 Braf Bad Prkci EGFR1%IOB%EGFR1 EGFR1 Flot2 Flot1 Racgap1 Krt18 Krt17 Ralgds Plcg2 Plcg1 Dok2 Myc Nck1 Rbck1 Stam Myh9 Ksr1 Lck Plce1 Ctnnal1 Plscr1 Pard3 Mapk7 Stip1 Nck2 Dok1 Rps6ka1 Hip1 Bcar1 Rps6ka3 Tnk2 Stk11 Vcl Ap2s1 Il17rd Nos3 Epha4 Otud6b Pttg1ip Nedd9 Usp31 Ptk6 Dyrk1b Ephb3 Scrib Dyrk1a Dnm1 Ppp1r14b Ephb4 Ephb1 Sdc4 Sdc3 Stam2 Dab2 Dynll1 Map3k14 Map4k5 Magi1 Trip6 Braf Dcbld2 Pias3 Ahcyl1 Efnb2 Sdc1 Dapp1 Hipk3 Hipk2 Jund Inppl1 Cd59b Antxr1 Sh3bgrl Wasl Ubash3b Ppp2r3a Siah2 Tfg Slc5a5 Rab5a Eno1b Ppp1r12a Afap1l2 Phpt1 mt-Co2 Arhgef7 Pygb Stx4a Frs2 Arhgef4 Wbp2 Epha2 Wnk1 Hist1h3h Zpr1 Slc25a5 Epha1 Hnrnpr Slc12a7 Git2 Huwe1 Tfrc Map2k7 Map2k5 Krt8 Aldoa Pxn Pkn2 Krt5 Krt7 Flnb Rasa1 Kit Ctnnd1 Tns1 Tns2 Tns3 Tns4 Adam9 Pitpna 2310030G06Rik Shb Arap1 Ldlr Casp9 Siah1a Sh3kbp1 Pdgfrb Aplp2 Abl2 Elk4 Prkd1 Spg20 Ndufa13 Pdzd11 Rin1 Baiap2l1 Phlpp1 Prkx Tom1l1 Appl2 Tom1l2 Appl1 Adrbk1 Rbbp7 Itga3 Tnip1 Prpf4b Sh3gl2 Pkm Zdhhc5 Ptpn23 Hnrnpa1 Snrpd2 Ptpn18 Ptprf Reps1 Snx33 Jup Slc38a2 Reps2 Ptprk Gab2 Hat1 Gab1 Vav3 Errfi1 Actn4 Pdcd6ip Vav2 Prkcg Ddx3x App Pgam1 Actn1 Grb7 Prkci Prkcb Actr2 Hnrnpdl Laptm4a Actr3 Pdlim4 Rgs16 Tagln2 Krt6a Ptrf Axl Cc2d1a Zfyve16 Atxn2 Prkaa2 Vasp Pebp1 Ptprr Hdac1 Snx5 Cdh1 Ensa Kirrel Ptpn12 Insr Sirpa Hgs Dsg2 Pdlim1 Cdh2 Cdh3 Eno1 Baiap2 Rfxank Egf Map3k1 Map3k2 Pfn1 Anks1 Map3k3 Plekha5 Map3k4 Nedd4 Garem Eps8 Pdpk1 Actb Pld2 Pld1 Myl12b Lyn Cdk1 Sdpr Yjefn3 Smu1 Dlg3 Arhgap5 Plekha6 Eif4g1 Limd1 Bcar3 Peak1 Itgb1 Cdk5 Cdk2 Pak1 Pik3ca Plec Prkcd Fyn Ephb2 Prkca Met Abl1 Col17a1 Egfr Pik3r2 Pik3r3 Pik3r1 Mtor Erbb2ip Smad2 Eif4ebp1 Smad3 Vim Pik3cb Ptpn11 Shc1 Pik3cd Rhoa Grb2 Pik3cg Itgb4 Dsp Ywhab Akt1 Irs2 Ptk2 Ywhaz Rac1 Bad Erbb2 Src Mapk3 Phldb2 Tkt Acp1 Mapk1 Caskin2 Mapk8 S100a14 Mapk9 Pvrl1 Cyld Nfkb1 Tln1 Snca S100a10 S100a11 Scamp3 Ap2a1 Jun Anxa4 Plekhn1 Git1 Dyrk3 Dyrk4 Anxa1 Anxa2 Gprc5a Cdv3 Myo6 Creb1 Ralbp1 Ptk2b Ptpn1 Sri Ahnak Mapk14 Ptpn5 Cblc Mta2 Cblb Araf Ptpn6 Sfpq Hras Mink1 Adam17 Dusp1 Cltc Iqgap1 Ap2b1 Clta Tyk2 Htt Epn3 Csk Pkp4 Pkp3 Crim1 Pkp2 Gsn Klf11 Eef1a2 Tollip Lsr Ddx6 Grb10 Grb14 Camk2a Eps15l1 Epn2 Epn1 Slitrk6 Eps15 Dock1 Sos1 Stxbp1 Sos2 Mvp Atp5c1 Rps10 Alb Cstb D8Ertd82e Cebpb Cebpa Frk Pik3c2b Elmo2 Tgif1 Ptpra Atp1a1 Marveld2 Mcf2 Sh2d3c Rps27l Abi1 Bcl2 Etl4 Arf4 Ptpre Asap3 Cav1 Mpzl1 Asap1 Cav2 Lpp Sh2d2a Cysrt1 Itch Trp53 Elf3 Usp6nl Tjp2 Fos Ldha Ripk1 Itsn2 Rela Sdcbp Gja1 Cbl Ralb Arhgap35 Serpinb3d Prkaa1 Arhgap32 Cttn Prkar1a Spry4 Spry2 Esyt1 Spry1 Spry3 Mprip Socs3 Ctbp1 Dock4 Socs1 Gsk3a Sh2b1 Rps6ka2 Map2k1 Map2k2 Khdrbs1 Pten Gsk3b Sp1 Raf1 Jak2 Elk1 Prkcz Stat5a Rps6ka5 Stat5b Stat1 Crkl Vav1 Crk Erbb3 Jak1 Map2k3 Stat2 Foxo1 Stat3 NOTCH%IOB%NOTCH Notch Mapk3 Mapk1 Nfkb1 Lck Pik3r2 Pik3r1 Smad3 Adam17 Gsk3b Numbl Hey2 Dll4 Hey1 Dll1 Tle1 Skp1a Maml3 App Skp2 Furin Mef2c Bloc1s1 Hivep3 Lef1 Hdac1 Smad4 Smad1 Jak2 Cul1 Maml1 Yy1 Maml2 Lfng Mfng Adam10 Fhl1 Psen2 Hdac2 Psen1 Wdr12 Tcf3 Ncstn Aph1b Itch Jag2 Jag1 Ncor1 Ring1 Dtx1 Notch2 Ncor2 Rela Notch1 Notch4 Rbx1 Numb Notch3 Kat2b Dll3 Cir1 Nov Rbpj Sap30 Sin3a Spen Hes6 Cntn1 Ascl1 Ep300 Hes1 Fbxw7 Stat3 Pofut1 Hes5 THROMBOPOIETIN%IOB%THROMBOPOIETIN Thrombopoietin Mapk3 Stat5b Gab1 Mapk1 Foxo3 Jak2 Shc1 Atxn2l Map2k1 Mpl Stat3 M-CSF%IOB%M-CSF M-CSF Mapk3 Ppp2ca Skap2 Itgb3 Mapk1 Mitf Pstpip2 Plcg2 Ets2 Plcg1 Grap2 Prkcd Sla2 Tfe3 Csf1r Casp8 Pik3r1 Ptk2b Csf1 Rps6kb2 Bcar1 Pak2 Myo18a Gab3 Eif4ebp1 Inpp5d Thoc5 Vim Ptpn2 Ptpn11 Ptpn6 Shc1 Map2k1 Map2k2 Grb2 Khdrbs1 Tyk2 Dnm1 Gab2 Akt1 Ptk2 Prkce Sos1 Inppl1 Raf1 Itgav Stat5a Stat5b Stat1 Fadd Src Pxn Ripk1 Cbl Rasa1 Jak1 Lyn Stat3 TGF_BETA_RECEPTOR%IOB%TGF_BETA_RECEPTOR TGF_beta_Receptor Ar Prkcd Myc Pard3 Pik3r2 Pik3r1 Erbb2ip Bcar1 Smad2 Smad3 Stk11 Atf2 Shc1 Rhoa Grb2 Dab2 Akt1 Trp73 Ptk2 Xpo4 Camk2g Runx2 Jund Ncoa1 Fnta Anapc2 Anapc5 Anapc4 Tgfbr3 Axin2 Kpnb1 Dvl1 Tab1 Xpo1 Axin1 Cited1 Sp1 Arrb2 Raf1 Lef1 Ski Smad4 Ube2d1 Sox9 Cul1 Tgfbr1 Nup153 Tgfbr2 Csnk1g2 Brca1 Tfdp2 Tfdp1 Cops5 Irf2bp1 Vdr Junb Pard6a Ccne1 Fzr1 Ube2d3 Eif3i Pml Pxn Crk Rbx1 Map2k6 Map2k3 Kat2b Ep300 Foxo1 Map4k1 Mapk3 Eid2 Ppp2ca Atf3 Vps39 Mapk1 Snx4 Mapk8 Pias1 Acvrl1 Nup214 Smad6 Strap Tgfb2 Tgfb1 Rnf111 Smad7 Jun Tgfb3 Fkbp1a Ctcf Ccnb2 Nfyb Nfya Ctnnb1 Anapc10 Pdk1 Cdkn1a Sdc2 Med15 Foxg1 Stk11ip Fosb Mapk14 Cdc16 Nfyc Sptbn1 Dync1i1 Camk2b Pja1 Ddx5 Camk2d Foxo3 Nedd4l Anapc7 Anapc1 Wwtr1 Hspa8 Ap2b1 Yap1 Rbl1 Ccnd1 Btrc Ppp2r2a Nme1 Rbl2 Ing2 Rock1 Rb1 Ppm1a Dynlrb1 Dynlrb2 Skp1a Stambpl1 Uchl5 Pias2 Prkcg Hnf4a Camk2a Snx2 Snx1 Cdc25a Zfyve9 Mef2c Snx6 Prkcb Eng Sos1 Zfyve16 Tgif1 Hdac1 Hgs Cav1 Ets1 Prkar2a Crebbp Ewsr1 Itch Cdc23 Trp53 Foxh1 Cdc27 Snip1 Cd44 Fos Cdk6 Skil E2f4 Map3k7 Dcp1a Sparc Hoxa9 Cdk4 Smurf2 Smurf1 Daxx Cdk1 E2f5 Gipc1 Zeb2 Foxo4 Zeb1 Trap1 Mef2a Prkar1b Esr1 Cdk2 TIE1 TEK%IOB%TIE1 TEK TIE1 TEK Stat5a Bmx Pak1 Mapk3 Tie1 Nos3 Stat5b Fes Tek Mapk1 Shc1 Pxn Map2k1 Dok2 Map2k2 Nck1 Raf1 Akt1 Elk1 Ptk2 Mapk14 Foxo1 Grb7 TNFSF3%IOB%TNFSF3 TNFSF3 Nfkbia Traf2 Nfkb1 Rela Nfkb2 Jun Ltb Lta Tnfrsf1a Tnfrsf1b Traf3 Relb Ltbr FLK2 FLT3%IOB%FLK2 FLT3 FLK2 FLT3 Mapk3 Stat5a Ptpn11 Atf2 Stat5b Mapk1 Foxo3 Shc1 Cebpa Cbl Jun Gab2 Lyn Gab1 Akt1 Jak2 Creb1 Flt3 Inpp5d Bad Stat3 Cblb TNFSF8%IOB%TNFSF8 TNFSF8 Nfkbia Mapk1 Bcl3 Traf2 Chuk Nfkb1 Ikbkb Traf1 Tnfrsf8 Rela Nfkbib Rel Tnfsf8 Nfkb2 Traf3 Akt1 Relb Map3k14 Mapk14 FAS%IOB%FAS Fas Casp3 Plec Prkcd Fyn Met Lck Egfr Vim Traf1 Map2k1 Map2k2 Gsk3b Akt1 Rac1 Hipk3 Fastk Mbd4 Lmnb1 Pkn1 Cd59b Bcl2l1 Cast Tcp1 Top1 Rfc1 Ube2i Wee1 Stk4 Stk3 Mst1 Eif2s1 Uso1 Psme3 Raf1 Gtf3c3 Max Cdk11b Fas Arhgdib Casp8ap2 Dedd2 Csnk2b Faf1 Numa1 Hspb1 Park2 Csnk1e Tial1 Tia1 Ube4b Pdcd6 Ripk2 Fasl Uba7 Srf Pkn2 Rasa1 Parg Satb1 Btk Casp6 Stk24 Csnk1a1 Igf1r Dffa Dedd Eif3j2 Casp9 Ezr Map3k5 Xpo5 Glrx Sptan1 Casp4 Eif4b Mapk3 Parp1 Xiap Mapk1 Mapk8 Mapk9 Anxa4 Diablo Casp1 Casp8 Casp7 Aifm1 Prkdc Pak2 Mapk14 Bax Casp2 Ptpn6 Rock1 Gsn Bmx Traf3 Insr Bcl2 Eif2ak2 Srp72 Map3k1 Bid Traf2 Cdc27 Fadd Ripk1 Nedd4 Rela Cflar Lyn Daxx EPO%IOB%EPO EPO Map4k1 Mapk3 Mapk1 Mapk8 Mapk9 Plcg2 Plcg1 Mst1r Jun Pik3r2 Pik3r1 Mtor Inpp5d Gsk3a Ptpn11 Nos3 Foxo3 Shc1 Map2k1 Map2k2 Gsk3b Gab2 Gab1 Akt1 Irs2 Braf Bad Hist1h2bj Epor Pag1 Dapk2 Gata4 Syk Sgk1 Gata1 Raf1 Jak2 Bcl2l11 Sh2b2 Hcls1 Stat5a Rps6ka5 Nfkbia Stat5b Stat1 Crkl Vav1 Cbl Lyn Foxo4 Foxo1 Stat3 CCR1%IOB%CCR1 CCR1 Mapk3 Stat1 Mapk1 Mapk8 Mapk9 Src Nfkb1 Zap70 Prkcd Pxn Rela Jak1 Ptk2b Ccl3 Ptk2 Ccr1 Gna14 Ccl7 Mapk14 Creb3 Stat3 Ccl5 Ccl4 CCR9%IOB%CCR9 CCR9 Mapk3 Mapk1 Mapk8 Cd226 Ccl25 Itgb7 Ccr9 Madcam1 Itga4 Rdx Gsk3b Msn Jak3 Cdh1 Akt1 Ezr Mapk14 Foxo1 BDNF%IOB%BDNF BDNF Mapk3 Tiam1 Syn1 Frs3 Mapk1 Gabrb3 Ngfr Mapk8 Igf2bp1 Mapk9 Gria1 Plcg1 Ntrk2 Kidins220 Fyn Ncam1 Kcna3 Ntrk1 Camk4 Prkaa2 Raf1 Relb Ctnnb1 Mapk7 Elk1 Sh2b2 Frs2 Creb1 Sirpa Ptk2b Mtor Eif4ebp1 Sh2b1 Foxo3 Shc1 Gsk3b Akt1 Irs2 Irs1 Shc4 Grin2b Tsc2 Bad Acacb Grin1 ID%IOB%ID ID Elk4 Atf3 Id1 Id2 Psmd4 Myf6 Myog Elk1 Myf5 Smad3 Tcf12 Tcf7l2 Tcf3 Elk3 Pax8 Myod1 Id3 Id4 Pax2 Pax5 Srebf1 Rbl1 Rbl2 Rb1 Hes1 Cdk2 G-CSF%IOB%G-CSF G-CSF Mapk3 Mapk1 Il3ra Csf3r Csf3 Fth1 Pom121 Tec Syp Pla2g1b Cdkn1b Cish Syk Hck Lck Jak2 Rps6ka1 Csnk1e Mapk14 Inpp5d Stat5a Gsk3a Ptpn11 Nos3 Stat5b Stat1 Shc1 Vav1 Notch2 Grb2 Tyk2 Notch1 Rel Cbl Jak1 Gsk3b Gab2 Lyn Akt1 Socs3 Bad Stat3 Prkci Cdk2 CXCR4%IOB%CXCR4 CXCR4 Mapk3 Pak1 Mapk1 Plcg2 Nfkb1 Plcg1 Prkcd Fyn Nck1 Lck Grk6 Vcam1 Gnai1 Was Egfr Ctnnb1 Pik3r2 Ackr3 Limk1 Lcp2 Dok1 Pik3r1 Ptprc Creb1 Itgb2 Ptk2b Pim1 Cxcr4 Bcar1 Esr2 Rps6ka3 Cxcl12 Itk Inpp5d Icam1 Ccr5 Cblb Ptpn11 Ptpn6 Foxo3 Rps6ka2 Chuk Ikbkb Rhoa Hspa8 Map2k1 Map2k2 Stat4 Nfkbib Tyk2 Ywhab Gsk3b Sdc4 Akt1 Vav2 Ptk2 Rac1 Bad Syk Arrb2 Raf1 Jak3 Jak2 Elk1 Prkcz Nfkbia Stat5b Stat1 Crkl Vav1 Src Zap70 Pxn Rela Crk Fyb Cbl Jak1 Rasa1 Itga4 Gna13 Usp14 Map2k3 Tff2 Lyn Stat2 Socs3 Foxo1 Stat3 Socs1 TNFSF1%IOB%TNFSF1 TNFSF1 Tnfrsf14 Nfkbia Nfkb1 Tnfrsf19 Rela Jun Nfkb2 Ltb Lta Tnfrsf1a Tnfrsf1b Ikbkg Traf3 Relb Akt1 Ltbr CCR7%IOB%CCR7 CCR7 Mapk3 Mapk1 Foxo3 Mapk8 Mapk9 Plcg1 Ccr7 Adrb2 Map2k4 Rela Mapk10 Gsk3b Akt1 Jak2 Mtor Ptk2b Mapk14 Foxo1 GDNF%IOB%GDNF GDNF Mapk3 Mapk1 Plcg1 Dok2 Fyn Jun Met Raf1 Mapk7 Creb1 Dok1 Pik3r1 Ptk2b Bcar1 Rps6ka3 Cblb Nfkbia Shc1 Src Map2k1 Pxn Map2k2 Crk Th Cbl Gab2 Dok5 Dok4 Gab1 Ret Cdk1 Akt1 Cdc25c Ptk2 Dok6 WNT%IOB%WNT Wnt Prkcd Prkca Gsk3a Rhoa Ywhab Gsk3b Akt1 Dab2 Yes1 Prkce Rac1 Wnt11 Wnt3 Wnt2 Wnt1 Ror1 Frzb Wnt6 Wnt4 Rspo3 Rspo2 Axin2 Ror2 Rspo1 Dvl1 Apc Axin1 Ctbp2 Arrb2 Raf1 Lef1 Smad1 Arhgef4 Csnk1e Tcf3 Src Prkcq Map2k4 Csnk1a1 Nlk Mapk3 Dvl2 Ppp2ca Sox1 Prkaca Mapk1 Mapk8 Wnt5a Kl Mark2 Wnt5b Jun Chrna7 Lrp1 Mesdc2 Wnt3a Ctnnb1 Pi4k2a Pip5k1b Gpc3 Prkch Frat2 Fzd10 Rps6kb2 Ppp1r1b Wif1 Wnt7b Wnt7a Arrb1 Dvl3 Pin1 Tcf7l2 Bcl9 Fzd9 Gckr Sfrp4 Pparg Nfatc2 Ppp1ca Pax2 Sfrp1 Sfrp2 Wnt9a Wnt9b Ccnd1 Lrp5 Btrc Jup Ryk Ilk Lrp6 Daam1 Setdb1 Chd7 Kremen1 Fzd6 Dixdc1 Csnk1d Dkk1 Prkcg Fzd4 Fzd5 Fzd7 Tcf4 Fzd1 Fzd8 Fzd2 Prkcb Fzd3 Cdh1 Cdh2 Map3k1 Map3k4 Cdk6 Map3k7 Ctbp1 CD40%IOB%CD40 CD40 Mapk3 Mapk1 Mapk8 Mapk9 Plcg2 Myc Fyn Jun Syk Lck Traf3 Jak3 Birc3 Pik3r1 Fgr Mapk14 Nfkbia Stat1 Traf2 Chuk Ikbkb Map2k1 Stat6 Lyn Akt1 Stat3 GM-CSF%IOB%GM-CSF GM-CSF Mapk3 Parp1 Mapk1 Mapk8 Mapk9 Plcg1 Ephb2 Tgfb1 Prkca Stam Mapk7 Pik3r2 Casp8 Pik3r1 Ptprc Creb1 Bcar1 Mapk14 Gsk3a Ptpn11 Ptpn6 Foxo3 Rps6ka2 Shc1 Bcl3 Chuk Ikbkb Map2k1 Map2k2 Grb2 Gsk3b Gab1 Stam2 Akt1 Irs2 Yes1 Ywhaz Bad Fes Tgfbr3 Tec Nfkb2 Syk Hck Raf1 Jak3 Jak2 Elk1 Pdia3 Sh2b2 Stat5a Nfkbia Dpysl2 Stat5b Hnrnph1 Stat1 Crkl Csf2ra Pfn1 Csf2rb2 Vav1 Pla2g4a Park7 Cct5 Pxn Mad2l1 Ganab Csf2 Gnb2l1 Slc2a1 Cbl Prdx3 Jak1 Kit Map2k6 Map2k3 Lyn Ezr Sptan1 Stat3 IFN-GAMMA%IOB%IFN-GAMMA IFN-gamma Mapk3 Prkaca Mapk1 Mapk8 Plcg2 Prkcd Cebpb Jun Raf1 Map3k11 Egfr Jak2 Creb1 Hoxa10 Ptk2b Irf8 Mapk11 Mapk14 Irf2 Ifngr1 Irf1 Spi1 Stat5a Stat5b Stat1 Crkl Vav1 Pla2g4a Src Prkcq Stat6 Crk Cbl Jak1 Gsk3b Akt1 Stat2 Prkce Stat3 Eif4b ANDROGENRECEPTOR%IOB%ANDROGENRECEPTOR AndrogenReceptor Ar Casp3 Egfr Pik3r1 Smad3 Pten Gsk3b Akt1 Pias3 Hipk3 Runx2 Ncoa1 Top1 Ube2i Sp1 Smad4 Cdk11b Brca1 Ncoa3 Hspb1 Ccne1 Src Park7 Pxn Ncor2 Gnb2l1 Kat2b Sin3a Ep300 Foxo1 Stat3 Parp1 Prkd1 Pias1 Appl1 Jun Casp1 Ctnnb1 Casp8 Casp7 Xrcc5 Ppp1ca Patz1 Hspa8 Nsd1 Nelfcd Hsp90aa1 Ccnd1 Xrcc6 Cdc37 Ranbp9 Rnf14 Nrip1 Whsc1 Slc25a4 Gsn Rb1 Arnt Cdk9 Hsp90b1 Cdk7 Rchy1 Pias2 Senp1 Aes Tgfb1i1 Spdef Tcf4 Sf1 Cdc25a Dapk3 Bag1 Psmc3ip 4930550L24Rik Brinp1 Rbak Svil Foxa1 Flna Nr3c1 Vip Cdc25b Rnf4 Pias4 Nr2c2 Cebpa Nr2c1 Pnrc1 Etv5 Lpxn Tgif1 Ddc Rad54l2 Hdac1 Pou2f1 Uxt Il6st Gtf2h1 Hspa5 Ran Trim68 Mdm2 Rac3 Nono Tmf1 Cav1 Ccnd3 Pa2g4 Nr0b2 Ccnh Stub1 Pelp1 Prdx1 Ncoa2 Ncoa6 Calr Efcab6 Gtf2f1 Kat5 Rela Pak6 Gtf2f2 Zmiz1 Ahr Kat7 Zmiz2 Daxx Prmt1 Fhl2 Esr1 TNFALPHA%IOB%TNFALPHA TNFalpha Nlrp4e Dok1 Map2k1 Mapkapk2 Map3k14 Pias3 Tab1 Prkcz Hist1h3h Cops5 Hspb1 Stat5a Rps6ka5 Stat1 Map2k5 Ube2d3 Pml Map2k6 Map3k11 Hsp90aa1 Cdc37 Gab1 Cdk9 Skp1a Ddx3x Brinp1 Flna Nr2c2 Syk Hdac1 Hspa5 Map3k1 Map3k2 Map3k3 Casp3 Prkcd Egfr Ptpn11 Ywhae Bcl3 Chuk Ikbkb Traf1 Tnfrsf8 Nfkbib Rel Ywhab Akt1 Ptk2 Ywhaz Ywhah Pkn1 Ube2i Cul1 Faf1 Hdac2 Src Gnb2l1 Fbxw7 Nupr1 Mapk3 Tbk1 Fbxw11 Mapk1 Mapk8 Mapk9 Mark2 Nfkb1 Copb2 Hsp90ab1 Ppp6c Ppp1r13l Kcnq1 Jun Birc2 Gtf2i Pfdn2 Ikbkg Casp8 Casp7 Creb1 Mapk14 Bax Casp2 Polr1d Polr1e Rasal2 Smarcb1 Spag9 Fkbp5 Kpna3 Kpna6 Psmd1 Hspa8 Iqgap2 Psmd7 Map3k8 Btrc Polr1a Irak1bp1 Polr1b Polr1c Cradd Ikbkap Rb1 Tifa Usp11 Ikbke Akap8 Bag4 Lrpprc Papola Psmb5 Smarcc1 Smarcc2 Akt2 Usp2 Bcl7a Rps11 Mcm5 G3bp2 Mtif2 Cdc34 Smarce1 Ktn1 Hspa1a Sec16a Alpl Mcm7 Actl6a Prc1 Nfkbiz Nfkb2 Polr2h Dcaf7 Mylk Tnfrsf1a Psmd3 Tnfrsf1b Tnfaip3 Traf3 Psmd6 Relb Mlc1 Commd1 Txlna Psmd2 Tnf Psmc2 Psmc1 Smarca4 Cops3 Trpc4ap Cav1 Tnfrsf11a Psmc3 Glg1 Tradd Trappc9 Nfkbia Ccnt1 Pdcd2 Crebbp Bid Tnip2 Tab3 Trp53 Traf2 Nkiras1 Fadd Nkiras2 Tab2 Rpl4 Ripk1 Azi2 Rela Fbl Ripk3 Map3k7 Fancd2 Traf7 Cflar Traf4 Traf6 Rnf25 Tbkbp1 Psmd12 Tank Rasa3 Psmd13 Hdac6 Nfkbie Dpf2 Nsmaf Peg3 Unc5cl Ywhag Glb1 Trib3 Zfand5 HEDGEHOG%IOB%HEDGEHOG Hedgehog Prkaca Med1 Kif27 Hhip Adrbk1 Arrb2 Ski Ctnnb1 Smad1 Sdc2 Crebbp Ywhae Gli2 Dhh Ptch1 Dyrk1a Nr2e1 Ptch2 Shh Sufu Hhat Boc Akt1 Ihh Cdon Med12 Sin3a Gli3 Gli1 Stk36 Smo Gm10094 Med23 Rab23 Med6 Cdk8 Gas1 KITRECEPTOR%IOB%KITRECEPTOR KitReceptor Mapk3 Pak1 Mapk1 Pik3ca Mitf Mapk8 Tnfrsf10b Plcg1 Fyn Prkca Jun Abl1 Was Pik3r2 Dok1 Pik3r1 Mtor Rps6ka1 Mapk14 Eif4ebp1 Inpp5d Cblb Fer Gsk3a Ptpn11 Socs6 Ptpn6 Atf2 Grap Hras Il7r Ptpru Shc1 Socs4 Nfatc2 Socs5 Cltc Map2k1 Map2k2 Grb2 Gsk3b Gab2 Akt1 Yes1 Grb10 Bad Grb7 Prkcb Actr2 Sos1 Fes Tec Epor Hck Raf1 Spred2 Jak3 Spred1 Jak2 Elk1 Sh2b2 Fgr Lat Gys1 Sh2b3 Stap1 Matk Mpdz Wipf1 Kitl Stat5a Stat5b Stat1 Crkl Csf2rb2 Vav1 Src Mad2l1 Rela Crk Cbl Rasa1 Kit Lyn Btk Ep300 Sh3kbp1 Stat3 Socs1 BIOCARTA_IL5_PATHWAY%MSIGDB_C2%BIOCARTA_IL5_PATHWAY BIOCARTA_IL5_PATHWAY Il1b Cd4 Il6 Ccr3 Il5ra Il5 H2-Eb1 Ccl11 Il4 HALLMARK_G2M_CHECKPOINT%MSIGDB_C2%HALLMARK_G2M_CHECKPOINT HALLMARK_G2M_CHECKPOINT Wrn Pura Stmn1 Lig3 Kif4 Rbm14 Notch2 Cdc45 Hmgb3 Srsf10 Ss18 Kif11 Kif15 Dmd Dbf4 Pola2 Tfdp1 Marcks Pml Brca2 Slc7a5 Foxn3 Egf Sfpq Prim2 Plk1 Plk4 Setd8 Polq Hoxc10 Hus1 Prmt5 Exo1 Rpa2 Gspt1 Ccna2 Fbxo5 Efna5 Srsf2 Cenpf Cdc25a Hira Cdc25b Cenpe Odc1 Nup50 Ddx39 Smc1a Arid4a Nusap1 Rad21 Racgap1 Nek2 Atrx Ube2c Mtf2 Pttg1 Stil Pbk Fancc Hspa8 Ccnd1 Rbl1 Orc6 Myc Orc5 Smarcc1 Ccnf Hmmr Papd7 Cdkn2c Cul4a Stag1 Ccnt1 Hn1 Snrpd1 Zak Tnpo2 Kif20b Prpf4b Ezh2 Cbx1 Chaf1a Xpo1 Dkc1 Slc38a1 Lbr Hmga1 Rasal2 Kif23 Tra2b Pole Nasp Rps6ka5 Kif22 Slc7a1 Chmp1a Abl1 Kpnb1 Chek1 Srsf1 Katna1 Rad54l Cenpa Espl1 Smc4 Smc2 Casc5 Kif5b Mad2l1 Syncrip Hist1h2bg Sqle Upf1 Tmpo Ewsr1 Mapk14 Ttk Mki67 Birc5 Sap30 Kif2c Hnrnpu Whsc1 Cdc27 Cdc20 Mybl2 Nolc1 Cdc7 Cdk1 Cdc6 Tacc3 Aurkb H2afz H2afx Top2a Hif1a Aurka Atf5 Lmnb1 Dtymk Cul1 Smad3 Cul5 Ythdc1 Bcl3 Bub1 Dr1 Bub3 Slc12a2 Cul3 Cdkn3 Traip Mnat1 Tgfb1 Cdkn1b Ccnb2 Top1 Ilf3 Bard1 Ctcf Ndc80 Numa1 E2f4 Tpx2 Tle3 E2f3 Prc1 Troap Meis2 Casp8ap2 Suv39h1 Mcm3 Cdk4 Mcm2 E2f2 Rad23b Hnrnpd E2f1 Gins2 Pds5b Pafah1b1 Mt2 Cks1b Incenp Mcm5 Mcm6 Meis1 Uck2 G3bp1 PID_E2F_PATHWAY%MSIGDB_C2%PID_E2F_PATHWAY PID_E2F_PATHWAY Tfdp1 Mybl2 Cdk1 Prmt5 Cdc6 Cdkn1b Ccna2 Orc1 Kat2b Ccnd3 Trp73 Crebbp Cdc25a Cbx5 Cdkn2a Apaf1 Atm Sult2a1 Ep300 Ces1d Hic1 Ces5a Casp7 Sirt1 Wasf1 Xrcc1 Uxt Tk1 E2f6 E2f5 Ranbp1 Rb1 E2f7 Ces2h Dhfr Cdk2 Rbl1 Rbl2 Myc Kat2a Topbp1 Trim28 E2f4 Rrm2 Cebpa Tfe3 E2f3 Rrm1 Cdkn2c Hdac1 Mcl1 Ccne2 Ces3b Mcm3 Ccne1 E2f2 E2f1 Cdkn1a Hbp1 Plau Pola1 Sp1 Rbbp8 Trrap Ces4a Rybp Brca1 Tfdp2 Yy1 Tyms Smarca2 Serpine1 Rbbp4 ST_GAQ_PATHWAY%MSIGDB_C2%ST_GAQ_PATHWAY ST_GAQ_PATHWAY Nfkbil1 Cfb Akt3 Phka2 Tonsl Gnaq Akt1 Pdk1 Nfkb2 Pik3cb Akt2 Itpr3 Adrbk1 Nfkbib Nfkbie Nfkbia Ikbkg Dag1 Pitx2 Nfkb1 Pld3 Pld2 Itpkb Pld1 Itpr1 Itpka Itpr2 PID_MTOR_4PATHWAY%MSIGDB_C2%PID_MTOR_4PATHWAY PID_MTOR_4PATHWAY Ulk1 Eef2k Poldip3 Sspo Ikbkb Eif4a1 Ulk2 Ywhaz Tsc2 Tsc1 Akt1s1 Pdcd4 Prkca Prr5 Mlst8 Rps6ka1 Map2k1 Map2k2 Pdpk1 Pml Rrn3 Hras Mtor Ddit4 Rptor Braf Clip1 Eif4ebp1 Pxn Sfn Srebf1 Deptor Rictor Akt1 Rragd Eif4b Rragb Eif4e Rragc Ywhae Rraga Rhoa Fbxw11 Eef2 Atg13 Ywhab Rb1cc1 Ppargc1a Mapkap1 Sgk1 Nras Irs1 Pld2 Mapk1 Mapk3 Pld1 Ywhah Ywhag Raf1 Rac1 Cdk2 Ccne1 Kras Yy1 PID_IL8_CXCR2_PATHWAY%MSIGDB_C2%PID_IL8_CXCR2_PATHWAY PID_IL8_CXCR2_PATHWAY Vasp Dock2 Plcb3 Gnai2 Arrb1 Cxcr2 Pik3r6 Arrb2 Rab11a Prkca Elmo1 Gnb1 Pdpk1 Akt1 Hck Dnm1 Prkcg Pik3cg Rab5a Rab7 Prkcb Ppp2ca Ppp2r1a Fgr Lyn Gna14 Pld2 Rac2 Gng2 Plcb1 Cbl Gna15 Plcb2 PID_CONE_PATHWAY%MSIGDB_C2%PID_CONE_PATHWAY PID_CONE_PATHWAY Pde6h Gnb5 Guca1b Guca1a Grk1 Rdh5 Lrat Slc24a2 Gngt2 Rgs9 Rgs9bp Gnb3 Rdh12 Cngb3 Rpe65 Pde6c Gucy2f Cnga3 Gnat2 Gucy2e Arr3 BIOCARTA_TALL1_PATHWAY%MSIGDB_C2%BIOCARTA_TALL1_PATHWAY BIOCARTA_TALL1_PATHWAY Mapk8 Traf2 Mapk14 Traf3 Map3k14 Traf6 Tnfsf13b Tnfrsf13c Tnfrsf13b Rela Nfkb1 Chuk Tnfsf13 Tnfrsf17 PID_GMCSF_PATHWAY%MSIGDB_C2%PID_GMCSF_PATHWAY PID_GMCSF_PATHWAY Sos1 Csf2 Ikbkb Ywhaz Shc1 Map2k1 Osm Map2k2 Pim1 Stat5b Stat5a Hras Cish Irf8 Gab2 Csf2ra Pik3ca Prkacb Csf2rb2 Prkaca Fos Jak2 Syk Ccl12 Pik3r1 Stat1 Inpp5d Kras Stat3 Ptpn11 Grb2 Lyn Nras Mapk1 Mapk3 Raf1 PID_NEPHRIN_NEPH1_PATHWAY%MSIGDB_C2%PID_NEPHRIN_NEPH1_PATHWAY PID_NEPHRIN_NEPH1_PATHWAY Arrb2 Plcg1 Pik3ca F2rl2 Bad Prkcz Cd2ap Mapk10 Nphs1 Nphs2 Wasl Pard6a Mapk9 Nck2 Akt1 Pik3r3 Map2k4 Pik3r1 Nck1 Mapk8 Tjp1 Pik3r2 Prkci Trpc6 Pik3cb Fyn Grb2 Pik3cd Jun Kirrel Rac1 HALLMARK_PEROXISOME%MSIGDB_C2%HALLMARK_PEROXISOME HALLMARK_PEROXISOME Hras Ywhah Smarcc1 Abcd2 Abcd3 Slc25a17 Bcl10 Esr2 Slc25a19 Ctbp1 Hsd3b7 Pex13 Pex14 Cdk7 Acsl4 Acsl5 Acot8 Gstk1 Acsl1 Sult2b1 Cnbp Dlg4 Scp2 Slc25a4 Abcd1 Top2a Atxn1 Ttr Msh2 Cat Hsd17b11 Hsd11b2 Scgb1a1 Nr1i2 Cel Aldh9a1 Crat Ehhadh Dhcr24 Cln6 Hmgcl Cln8 Ugt2b38 Tspo Pex11a Pex11b Fabp6 Crabp1 Serpina6 Fdps Ctps Acox1 Crabp2 Hsd17b4 Ech1 Cadm1 Cacna1b Slc35b2 Mvp Acaa1a Alb Pabpc1 Pex5 Prdx5 Pex6 Prdx1 Sema3c Abcc8 Nudt19 Abcc5 Abcb4 Itgb1bp1 Abcb9 Pex2 Hao2 Eci2 Ephx2 Ide Isoc1 Vps4b Fads1 Slc23a2 Siah1a Aldh1a1 Idi1 Dio1 Abcb1a Dhrs3 Slc27a2 Lonp2 Retsat Gnpat Rdh11 Sod2 Fis1 Ercc3 Ercc1 Elovl5 Rxrg Idh2 Idh1 Mlycd PID_ERA_GENOMIC_PATHWAY%MSIGDB_C2%PID_ERA_GENOMIC_PATHWAY PID_ERA_GENOMIC_PATHWAY Sra1 Pou4f1 Axin2 Ap1b1 Ddx54 Lmo4 Abca3 Ncor1 Prl Ncoa2 Ncoa3 Uba3 Mpg Pou4f2 Pcna Phb2 Trim59 Smad4 Esr2 Cd82 Cebpb Stat5a Ctsd Hdac4 Apbb1 Ncor2 Col18a1 Safb Calcoco1 Mta1 Greb1 Lcor Chuk Ep300 Ccnd1 Myc Atp5j Ncoa7 Nr0b2 Nedd8 Ube2m Hdac1 Ndufv3 Xbp1 Prdm15 Nrip1 Pgr C3 Ncoa1 Nr0b1 Pdia2 Anp32a Ddx17 Jun Hsf2 Esr1 Brca1 Ebag9 Dscam Med1 PID_ARF_3PATHWAY%MSIGDB_C2%PID_ARF_3PATHWAY PID_ARF_3PATHWAY Gga3 Clta Cd4 Gosr2 Ap2m1 Gbf1 Asap1 Arf1 Kdelr1 Cyth2 Ap2a1 Pld2 Arfip2 Arfgap1 Uso1 Copa Pip5k1a Rac1 Cltb PID_ECADHERIN_NASCENT_AJ_PATHWAY%MSIGDB_C2%PID_ECADHERIN_NASCENT_AJ_PATHWAY PID_ECADHERIN_NASCENT_AJ_PATHWAY Ctnnb1 Ctnnd1 Src Pip5k1c Cdh1 Arf6 Pik3ca Ccnd1 Iqgap1 Csnk2b Itgb7 Tiam1 Crk Akt1 Nme1 Ctnna1 Nckap1 Dlg1 Pik3r1 Rapgef1 Tjp1 Rap1b Abi1 Rap1a Cyfip2 Itgae Rhoa Mllt4 Klhl20 Wasf2 Ap1m1 Cttn Jup Csnk2a2 Vav2 Rac1 BIOCARTA_CACAM_PATHWAY%MSIGDB_C2%BIOCARTA_CACAM_PATHWAY BIOCARTA_CACAM_PATHWAY Camk2a Camk1g Creb1 Camkk1 Camk1 Camkk2 Camk2b Camk4 Camk2d Camk2g BIOCARTA_MYOSIN_PATHWAY%MSIGDB_C2%BIOCARTA_MYOSIN_PATHWAY BIOCARTA_MYOSIN_PATHWAY Arhgef18 Rock1 Prkca Gnb1 Gnaq Myl7 Myl2 Mylk Arhgef9 Ppp1r12b Pkn1 Arhgap5 Arhgef4 Arhgef3 Arhgef2 Arhgef1 Prkcb Arhgef6 Gngt1 Gna13 Gna12 Arhgef10 Arhgef11 Arhgef12 Arhgef7 Arhgef19 Plcb1 Arhgef15 Arhgef16 Arhgef17 HALLMARK_CHOLESTEROL_HOMEOSTASIS%MSIGDB_C2%HALLMARK_CHOLESTEROL_HOMEOSTASIS HALLMARK_CHOLESTEROL_HOMEOSTASIS Sqle Pnrc1 Adh4 Pmvk Antxr2 Atf3 Tmem97 Fasn Fabp5 Srebf2 Fbxo6 Mvd Atf5 Fdps Ech1 Atxn2 S100a11 Nfil3 Actg1 Cd9 Fads2 Dhcr7 Gstm7 Avpr1a Cbs Acat2 Lpl Scd1 Hmgcr Cpeb2 Ethe1 Abca2 Jag1 Errfi1 Ctnnb1 Pcyt2 Alcam Tnfrsf12a Ebp Gldc Lgals3 Plaur Pdk3 Chka Nsdhl Cyp51 Clu Idi1 Aldoc Hsd17b7 Acss2 Fdft1 Gusb Pparg Mvk Mal2 Sema3b Trp53inp1 Anxa5 Lgmn Cxcl16 Trib3 Tm7sf2 Gpx8 Plscr1 Stard4 Gnai1 Fam129a Sc5d Lss Ldlr Stx5a SA_G1_AND_S_PHASES%MSIGDB_C2%SA_G1_AND_S_PHASES SA_G1_AND_S_PHASES Nxt1 Mdm2 Gm8882 Cdkn2a Arf1 Cdk4 E2f2 E2f1 Cdkn1a Trp53 Cdkn1b Arf3 Ccnd1 Cdk2 BIOCARTA_MPR_PATHWAY%MSIGDB_C2%BIOCARTA_MPR_PATHWAY BIOCARTA_MPR_PATHWAY Cdc25c Adcy1 Prkar2a Prkar2b Myt1 Acta1 Pin1 Gnb1 Rps6ka1 Hras Src Prkacb Cdk1 Pgr Prkar1b Paqr7 Prkar1a Arpc5 Gngt1 Paqr5 Arpc1a Cap1 Gnai1 Arpc2 Mapk1 Arpc3 Mapk3 Arpc4 Actr3 Actr2 Arpc1b BIOCARTA_IL12_PATHWAY%MSIGDB_C2%BIOCARTA_IL12_PATHWAY BIOCARTA_IL12_PATHWAY Cxcr3 Mapk8 Ifng Jun Mapk14 Il12b Cd247 Cd3d Ccr5 Stat4 Tyk2 Il12a Map2k6 Il12rb2 Etv5 Cd3g Il18r1 Cd3e Jak2 Il18 Il12rb1 BIOCARTA_AT1R_PATHWAY%MSIGDB_C2%BIOCARTA_AT1R_PATHWAY BIOCARTA_AT1R_PATHWAY Sos1 Pak1 Mef2d Prkca Map2k1 Shc1 Map2k2 Hras Src Gnaq Map2k4 Mapk8 Grb2 Atf2 Jun Agt Elk1 Egfr Prkcb Map3k1 Agtr1a Ptk2b Ptk2 Mapk1 Mapk3 Mef2c Raf1 Mef2a Rac1 BIOCARTA_CHEMICAL_PATHWAY%MSIGDB_C2%BIOCARTA_CHEMICAL_PATHWAY BIOCARTA_CHEMICAL_PATHWAY Tln1 Akt1 Apaf1 Bcl2 Atm Bax Parp1 Eif2s1 Stat1 Prkca Bid Casp6 Casp7 Casp3 Casp9 Bcl2l1 Prkcb Ptk2 Trp53 Pxn Bad BIOCARTA_CXCR4_PATHWAY%MSIGDB_C2%BIOCARTA_CXCR4_PATHWAY BIOCARTA_CXCR4_PATHWAY Crk Gnaq Pik3r1 Prkca Gnb1 Map2k1 Prkcb Hras Gngt1 Ptk2b Ptk2 Rela Nfkb1 Plcg1 Pik3ca Gnai1 Mapk1 Pxn Cxcl12 Mapk3 Pik3c2g Bcar1 Raf1 Cxcr4 HALLMARK_KRAS_SIGNALING_DN%MSIGDB_C2%HALLMARK_KRAS_SIGNALING_DN HALLMARK_KRAS_SIGNALING_DN Slc6a3 Nudt10 Ryr1 Myh7 Brdt Kcnd1 Calm4 Ryr2 Bmpr1b Mast3 Cpb1 H2afy2 Sprr1b Capn9 Mefv Sphk2 Ypel1 Cd80 Rsad2 Cyp11b2 Fshb Tcf7l1 Cacna1f Tff2 Adra2c Chst2 Nudt11 Tg Zc2hc1c Synpo Col2a1 Slc30a3 Abcg4 Thrb P2rx6 Pde6b Ccdc106 Cpeb3 Thnsl2 Tcl1 Krt15 Zbtb16 Actc1 Ptgfr Tlx1 Pdcd1 Clstn3 Myot Snn Kmt2d Gamt Dlk2 Hc Stag3 Nr6a1 Scn10a Grid2 Kcnn1 Celsr2 Arpp21 Atp4a Slc16a7 Serpina10 Irs4 Sepp1 Alox12b Lgals7 Ckm Tgfb2 Gdnf Pdk2 Slc6a14 P2ry4 Ptprj Ntf3 Slc38a3 Dtnb Hnf1a Sptbn2 Camk1d Epha5 Cd207 Cldn16 Igfbp2 Nos1 Chrng Plag1 Shox2 Cdkal1 Prodh Sstr4 Oxt Clps Ccna1 Zfp112 Gpr3 Tgm1 Myo15 Gtf3c5 Akr1b10 Ybx2 Pnmt Nrip2 Krt1 Msh5 Krt5 Kcnq2 Cldn8 Slc12a3 Slc5a5 Rgs11 Cntfr Atp6v1b1 Tfcp2l1 Krt4 Klk8 Ribc2 Klk7 Ccr8 Sox10 Gp2 Prop1 Upk3b Park2 Nr4a2 Wnt16 Smpx Sncb Efhd1 Serpinb2 Ngb Pax4 Pax3 Edar Lypd3 Cdh16 Gp1ba Cd40lg Slc25a23 Npy4r Copz2 Tex15 Itih3 Btg2 Tshb Cacng1 Skil Tas2r108 Tenm2 Arhgdig Vpreb2 Cpa2 Calca Adck3 Asb7 Fgf22 Tnni3 Gprc5c Lfng Ambn Ccdc132 Insl5 Dcc Sidt1 Cyp39a1 Kcnmb1 Htr1b Fgf16 Slc29a3 Htr1d Abcb11 Klhdc8a Tfap2b Idua Mfsd6 Pcdhb1 Gpr19 Magix Mthfr Edn1 Edn2 Itgb1bp2 Kcne2 Entpd7 Pkp1 Krt13 Fgfr3 Bard1 Il5 Nphs1 Egf Sgk1 Ifng Il12b Hsd11b2 Scgb1a1 Ugt2b38 BIOCARTA_IL4_PATHWAY%MSIGDB_C2%BIOCARTA_IL4_PATHWAY BIOCARTA_IL4_PATHWAY Shc1 Il2rg Jak1 Jak3 Akt1 Irs1 Stat6 Il4ra Il4 Grb2 BIOCARTA_TCR_PATHWAY%MSIGDB_C2%BIOCARTA_TCR_PATHWAY BIOCARTA_TCR_PATHWAY Sos1 Prkca Shc1 Map2k1 Rasa1 Cd247 Cd3d Nfatc3 Hras Nfatc1 Ptpn7 Nfatc2 Plcg1 Pik3ca Cd3g Fos Cd3e Map2k4 Pik3r1 Lat Nfatc4 Lck Mapk8 Vav1 Ppp3cc Ppp3ca Fyn Zap70 Grb2 Ppp3cb Jun Pik3cg Elk1 Prkcb Map3k1 Nfkbia Rela Nfkb1 Mapk3 Raf1 Rac1 BIOCARTA_G2_PATHWAY%MSIGDB_C2%BIOCARTA_G2_PATHWAY BIOCARTA_G2_PATHWAY Chek1 Cdc25c Mdm2 Gadd45a Myt1 Cdc25a Prkdc Chek2 Cdc25b Atm Ep300 Rps6ka1 Cdkn1a Cdc34 Trp53 Wee1 Plk1 Brca1 Ywhah Cdk1 BIOCARTA_NO1_PATHWAY%MSIGDB_C2%BIOCARTA_NO1_PATHWAY BIOCARTA_NO1_PATHWAY Prkar2a Prkar2b Ryr2 Acta1 Prkacb Chrna1 Nos3 Pde3a Bdkrb2 Akt1 Tnni1 Pde2a Prkar1b Prkar1a Kdr Hsp90aa1 Cav1 Prkg2 Chrm1 Vegfa Flt4 Pde3b Slc7a1 Flt1 Kng2 Prkg1 BIOCARTA_GRANULOCYTES_PATHWAY%MSIGDB_C2%BIOCARTA_GRANULOCYTES_PATHWAY BIOCARTA_GRANULOCYTES_PATHWAY Icam1 Sell Itgal Selp Pecam1 Selplg Csf3 Il1a Ifng Hc Itgam Itgb2 Tnf PID_ECADHERIN_KERATINOCYTE_PATHWAY%MSIGDB_C2%PID_ECADHERIN_KERATINOCYTE_PATHWAY PID_ECADHERIN_KERATINOCYTE_PATHWAY Vasp Akt1 Ctnna1 Pik3r1 Fyn Akt2 Rhoa Casr Zyx Ctnnb1 Ctnnd1 Ajuba Egfr Src Cdh1 Plcg1 Pik3ca Jup Pip5k1a Rac1 ST_TYPE_I_INTERFERON_PATHWAY%MSIGDB_C2%ST_TYPE_I_INTERFERON_PATHWAY ST_TYPE_I_INTERFERON_PATHWAY Jak1 Ifnb1 Irf9 Tyk2 Ifnar1 Ptpru Stat2 Reg1 Stat1 ST_GA13_PATHWAY%MSIGDB_C2%ST_GA13_PATHWAY ST_GA13_PATHWAY Rock1 Nfkbil1 Prkd1 Srf Tbxa2r Map3k5 Rdx Rock2 Cfb Dlg4 Akt3 Phka2 Tonsl Akt1 Pdk1 Nfkb2 Map2k4 Bcl2 Mapk8 Pik3cb Akt2 Nfkbib Nfkbie Map3k1 Nfkbia Ikbkg Gna13 Ptk2 Nfkb1 Arhgef11 Pld3 Pld2 Pld1 BIOCARTA_PITX2_PATHWAY%MSIGDB_C2%BIOCARTA_PITX2_PATHWAY BIOCARTA_PITX2_PATHWAY Apc Axin1 Lef1 Hdac1 Crebbp Gsk3b Fzd1 Wnt1 Dvl1 Ep300 Ctnnb1 Trrap Pitx2 Ldb1 Med1 PID_RAC1_PATHWAY%MSIGDB_C2%PID_RAC1_PATHWAY PID_RAC1_PATHWAY Mapk14 Stat5a Bcar1 Iqgap1 Crk Ctnna1 Nckap1 Mapk8 Abi1 Cyfip2 Stat3 Arpc5 Wasf2 Arpc2 Arpc3 Arpc4 Actr3 Actr2 Rac1 Arpc1b Pak1 Wasf1 Racgap1 Ctnnb1 Pip5k1c Cdh1 Map2k6 Map2k7 Brk1 Abi2 Baiap2 Map3k11 Mapk9 Iqgap3 Nox1 Map2k3 Map2k4 Pip5k1b Pak2 Noxa1 Limk1 Ncf1 Ncf2 Noxo1 Arhgap5 Arhgdia Atf2 Jun Map3k1 Cyba Cybb Pip5k1a Plcb2 PID_TRAIL_PATHWAY%MSIGDB_C2%PID_TRAIL_PATHWAY PID_TRAIL_PATHWAY Ikbkb Pik3r3 Map2k4 Pik3r1 Mapk8 Pik3r2 Pik3cb Pik3cd Dap3 Traf2 Cflar Tnfsf10 Fadd Map3k1 Tradd Ikbkg Ripk1 Casp8 Smpd1 Pik3ca Mapk1 Mapk3 Chuk Tnfrsf10b PID_P53_REGULATION_PATHWAY%MSIGDB_C2%PID_P53_REGULATION_PATHWAY PID_P53_REGULATION_PATHWAY Chek1 Gsk3b Pin1 Skp2 Usp7 Rchy1 Mapk14 Dyrk2 E4f1 Daxx Ccng1 Rpl11 Mdm4 Csnk1a1 Trp53 Rpl23 Ppp2r4 Ppp1r13l Setd8 Ppm1d Csnk1e Csnk1d Ttc5 Cse1l Prmt5 Akt1 Mapk8 Ccna2 Kat2b Crebbp Cdkn2a Atm Ep300 Prkcd Cdk2 Trim28 Huwe1 Csnk1g2 Mdm2 Kat8 Hipk2 Nedd8 Smyd2 Mapk9 Csnk1g3 Csnk1g1 Chek2 Kat5 Fbxo11 Ube2d1 Setd7 Rfwd2 Ppp2ca Yy1 Abl1 PID_ALPHA_SYNUCLEIN_PATHWAY%MSIGDB_C2%PID_ALPHA_SYNUCLEIN_PATHWAY PID_ALPHA_SYNUCLEIN_PATHWAY Park2 Slc6a3 Klk6 Tor1a Th Yes1 Park7 Src Ube2l3 Prkcd Maob Snca Grk5 Ppp2r5d Blk Stub1 Bad Uchl1 Fkbp1a Syk Sncaip Hck Lck Fyn Ptk2b Fgr Lyn Pld2 Mapk1 Mapk3 Pld1 Plcb2 BIOCARTA_SODD_PATHWAY%MSIGDB_C2%BIOCARTA_SODD_PATHWAY BIOCARTA_SODD_PATHWAY Traf2 Tnfrsf1a Bag4 Tnfrsf1b Fadd Tradd Ripk1 Casp8 Birc3 Tnf PID_CMYB_PATHWAY%MSIGDB_C2%PID_CMYB_PATHWAY PID_CMYB_PATHWAY Lef1 Wnt1 Ncor1 Pim1 Cebpb Hras Iqgap1 H2afz Ccna1 Nras Cdkn1b Zfhx3 Cd4 Lect2 Ptcra Yeats4 Tab2 Crebbp Hes1 Cdkn2a Cbx4 Pax5 Myod1 Snd1 Ets1 Ep300 Mat2a Ets2 Birc3 Sin3a Elane Cdk6 Spi1 Ube2i Mcm4 Gata1 Gata3 Ada Myb Adora2b Hspa8 Ccnd1 Mad1l1 Prtn3 Myc Rag2 Col1a2 Trim28 Cebpa Clta Hipk2 Bcl2 Zfpm1 Cd34 Kit Pias3 Ppp3ca Kras Csf1r Casp6 Ski Cdkn1a Gstm2 Myf6 Nlk Sp1 Anpep Ppid Atp2b1 Kitl Tab1 Tfec Ptgs2 Mpo Map3k7 Smarca2 Copa Car1 Slc25a3 Maf PID_AR_PATHWAY%MSIGDB_C2%PID_AR_PATHWAY PID_AR_PATHWAY Ncoa2 Uba3 Kdm1a Pias4 Tgif1 Fhl2 Zmiz1 Pias1 Appl1 Svil Lats2 Cmtm2b Akt1 Casp8 Ccnd3 Cdkn2a Prdx1 Cdk6 Ube2i Ctnnb1 Srf Ccnd1 Fkbp4 Hnrnpa1 Nkx3-1 Kdm3a Tmprss2 Gsn Ar Prkdc Ncoa6 Tgfb1i1 Nrip1 Rps6ka3 Carm1 Mak Pias3 Tcf4 Hip1 Kdm4c Vav3 Xrcc5 Zfp318 Ranbp9 Ctdsp1 Ptk2b Xrcc6 Pawr Brca1 Patz1 Tmf1 Cdk11b Ube3a Pa2g4 Med1 Snurf Pelp1 BIOCARTA_RANKL_PATHWAY%MSIGDB_C2%BIOCARTA_RANKL_PATHWAY BIOCARTA_RANKL_PATHWAY Ifnb1 Irf9 Ifnar1 Mapk8 Fosl2 Tnfrsf11a Traf6 Ifnar2 Fosl1 Tnfsf11 Rela Eif2ak2 Nfkb1 Fos BIOCARTA_HDAC_PATHWAY%MSIGDB_C2%BIOCARTA_HDAC_PATHWAY BIOCARTA_HDAC_PATHWAY Cabin1 Igf1r Mapk7 Igf1 Camk1g Hdac5 Myod1 Camk1 Mef2d Mapk14 Nfatc1 Nfatc2 Map2k6 Pik3ca Ins2 Insr Akt1 Pik3r1 Ppp3cc Ppp3ca Ppp3cb Pik3cg Ywhah Mef2c Mef2a SIG_CD40PATHWAYMAP%MSIGDB_C2%SIG_CD40PATHWAYMAP SIG_CD40PATHWAYMAP Nfkbil1 Mapk14 Pik3ca Mapk10 Mapk12 Map2k7 Cd40 Mapk11 Tonsl Mapk9 Mapkapk5 Dusp1 Gorasp1 Mapk13 Nfkb2 Map2k4 Pik3r1 Mapk8 Pik3cd Traf2 Traf3 Nfkbib Traf6 Nfkbie Nfkbia Ikbkg Mapk8ip3 Nfkb1 Mapk8ip2 Mapk8ip1 Mapk1 Syt1 Mapk3 BIOCARTA_LEPTIN_PATHWAY%MSIGDB_C2%BIOCARTA_LEPTIN_PATHWAY BIOCARTA_LEPTIN_PATHWAY Cpt1a Prkab1 Acaca Prkag1 Prkag3 Prkag2 Prkab2 Prkaa1 Lepr Prkaa2 Lep BIOCARTA_AGPCR_PATHWAY%MSIGDB_C2%BIOCARTA_AGPCR_PATHWAY BIOCARTA_AGPCR_PATHWAY Prkar1b Prkar1a Prkar2a Prkcb Prkar2b Arrb1 Gngt1 Grk4 Prkacb Prkca Gnb1 PID_TCR_CALCIUM_PATHWAY%MSIGDB_C2%PID_TCR_CALCIUM_PATHWAY PID_TCR_CALCIUM_PATHWAY Cabin1 Csf2 Cd40lg Il4 Il2ra Ifng Il2 Fasl Junb Nfatc3 Rcan1 Fosl1 Nfatc1 Chp1 Rcan2 Pou2f1 Nfatc2 Prkaca Fos Akap5 Ppp3r1 Fkbp1a Batf3 Ppp3ca Ppp3cb Jun Ptgs2 PID_EPO_PATHWAY%MSIGDB_C2%PID_EPO_PATHWAY PID_EPO_PATHWAY Sos1 Shc1 Bcl2l1 Mapk14 Stat5b Stat5a Hras Plcg1 Jak2 Irs2 Gab1 Crkl Epo Btk Plcg2 Tec Ptpn6 Bcl2 Pik3r1 Rapgef1 Mapk8 Stat1 Epor Rap1a Inpp5d Sh2b3 Trpc6 Ptpn11 Socs3 Grb2 Nfkb1 Lyn Cbl Vav2 PID_TGFBR_PATHWAY%MSIGDB_C2%PID_TGFBR_PATHWAY PID_TGFBR_PATHWAY Sos1 Axin1 Camk2a Shc1 Smad4 Pdpk1 Pml Daxx Eif2a Tgfbr3 Wwp1 Sptbn1 Tgfb2 Tgfbrap1 Itch Zfyve16 Nedd4l Xiap Ppp2r2a Dynlrb1 Smad3 Yap1 Smurf2 Ywhae Smurf1 Ppp2cb Rhoa Dact2 Zfyve9 Bambi Smad2 Rnf111 Cav1 Tgfb1 Smad7 Ppp1ca Tgfb3 Dab2 Strap Ppp1r15a Ctgf Tgfbr2 Tgfbr1 Tab2 Arrb2 Ctnnb1 Skil Fkbp1a Pard6a Grb2 Ppp2ca Tab1 Map3k7 BIOCARTA_PS1_PATHWAY%MSIGDB_C2%BIOCARTA_PS1_PATHWAY BIOCARTA_PS1_PATHWAY Apc Axin1 Gsk3b Fzd1 Wnt1 Dvl1 Hnf1a Ctnnb1 Btrc Notch1 Psen1 Adam17 Rbpj Dll1 PID_AURORA_B_PATHWAY%MSIGDB_C2%PID_AURORA_B_PATHWAY PID_AURORA_B_PATHWAY Stmn1 Cenpa Cbx5 Smc4 Smc2 Racgap1 Rasa1 Birc5 Kif2c Ppp2r5d Aurkb Aurka Mylk Sept1 Sgol1 Rhoa Bub1 Nsun2 Npm1 Ncapd2 Cul3 Klhl13 Tacc1 Incenp Vim Kif23 Evi5 Cdca8 Ppp1cc Pebp1 Des Kif20a Klhl9 Ndc80 Psma3 Ncaph PID_DELTA_NP63_PATHWAY%MSIGDB_C2%PID_DELTA_NP63_PATHWAY PID_DELTA_NP63_PATHWAY Krt14 Mre11a Pou2f2 Nrg1 Gsk3b Adrm1 Hells Hes1 Cdkn2a Vdr Il1a Col5a1 Atm Itga3 Rrad Rab38 Sec14l2 Perp Tcf7l1 T Axl Gpx2 Fosl2 Ppp2r5a Igfbp3 Dlx5 Stxbp4 Brca2 Gnb2l1 Notch1 Fbxw7 Ada Trp63 Fasn Sfn Mdm2 Wwp1 Bdkrb2 Top2a Itch Yap1 Hbp1 Krt5 Ccnb2 PID_ANGIOPOIETIN_RECEPTOR_PATHWAY%MSIGDB_C2%PID_ANGIOPOIETIN_RECEPTOR_PATHWAY PID_ANGIOPOIETIN_RECEPTOR_PATHWAY Shc1 Mapk14 Stat5b Stat5a Angpt2 Mmp2 Angpt4 Pxn Angpt1 Itgb1 Foxo1 Fes Tnf Dok2 Plg Nos3 F2 Elf2 Elf1 Grb7 Crk Tnip2 Akt1 Fgf2 Grb14 Mapk8 Itga5 Tek Bmx Fn1 Ptpn11 Rela Nfkb1 Pld2 Mapk1 Mapk3 Rac1 Pak1 Ets1 Rasa1 Pik3ca Pik3r1 Nck1 Fyn Grb2 Cdkn1a Elk1 Agtr1a Ptk2 SA_FAS_SIGNALING%MSIGDB_C2%SA_FAS_SIGNALING SA_FAS_SIGNALING Fas Cflar Fasl Pde6d Casp8 Endou Bcl2 Casp3 PID_ANTHRAX_PATHWAY%MSIGDB_C2%PID_ANTHRAX_PATHWAY PID_ANTHRAX_PATHWAY Map2k7 Il1b Map2k3 Map2k4 Pgr Nlrp1a Antxr1 Vcam1 Casp1 Map2k1 Map2k2 Map2k6 Antxr2 Mapk1 Mapk3 Il18 Tnf SA_CASPASE_CASCADE%MSIGDB_C2%SA_CASPASE_CASCADE SA_CASPASE_CASCADE Prf1 Gzmb Apaf1 Dffa Xiap Dffb Parp1 Scap Birc2 Birc3 Casp7 Casp3 Casp9 Fas Fasl Casp8 Srebf1 Srebf2 PID_INSULIN_PATHWAY%MSIGDB_C2%PID_INSULIN_PATHWAY PID_INSULIN_PATHWAY Sos1 Shc1 Exoc1 Rasa1 Exoc6 Exoc5 Pdpk1 Exoc4 Trip10 Hras Exoc7 Exoc2 Ptpn1 Pik3ca Eif4ebp1 F2rl2 Ins2 Exoc3 Insr Prkcz Pard6a Crk Akt1 Nck2 Grb14 Grb10 Pik3r1 Nck1 Rapgef1 Dok1 Rhoq Sh2b2 Prkci Ptpra Inpp5d Sorbs1 Foxo3 Akt2 Ptpn11 Grb2 Cav1 Sgk1 Irs1 Cbl BIOCARTA_RHO_PATHWAY%MSIGDB_C2%BIOCARTA_RHO_PATHWAY BIOCARTA_RHO_PATHWAY Rock1 Src Tln1 Baiap2 Gsn Pip5k1b Myl2 Limk1 Mylk Ppp1r12b Rhoa Arhgap5 Pfn1 Vcl Ophn1 Arpc5 Diap1 Arhgef1 Arhgap4 Arhgap1 Arhgap6 Arpc1a Arhgef11 Arpc2 Arpc3 Arpc4 Actr3 Pip5k1a Actr2 Arpc1b PID_EPHRINB_REV_PATHWAY%MSIGDB_C2%PID_EPHRINB_REV_PATHWAY PID_EPHRINB_REV_PATHWAY Efnb1 Efnb2 Yes1 Src Itgb3 Ephb2 Ephb1 Pik3ca Ephb4 Ptpn13 Blk Fga Fgb Fgg Cxcr4 Rgs3 Itga2b Tiam1 Nck2 Map2k4 Pik3r1 Hck Mapk8 Lck Dnm1 Fyn Fgr Lyn Map3k7 Rac1 PID_UPA_UPAR_PATHWAY%MSIGDB_C2%PID_UPA_UPAR_PATHWAY PID_UPA_UPAR_PATHWAY Vtn Klk4 Vldlr Ctrc Pdgfrb Mmp13 Mmp12 Hgf Itga3 Gpld1 Itgb5 Elane Src Itgb3 Plaur Fga Itgb1 Fgb Itgam Bcar1 Fgg Itgb2 Plg Crk Itga5 Fn1 Fpr3 Fpr1 Mmp3 Plau Egfr Fpr2 Pdgfd Ctsg Mmp9 Lrp1 Tgfb1 Dock1 Itgav Serpine1 Rac1 BIOCARTA_ACH_PATHWAY%MSIGDB_C2%BIOCARTA_ACH_PATHWAY BIOCARTA_ACH_PATHWAY Akt1 Pik3r1 Rapsn Musk Chrng Foxo3 Pik3cg Fasl Tert Chrnb1 Src Ptk2b Ptk2 Pik3ca Ywhah Bad BIOCARTA_VIP_PATHWAY%MSIGDB_C2%BIOCARTA_VIP_PATHWAY BIOCARTA_VIP_PATHWAY Prkar2a Prkar2b Gnaq Ppp3cc Ppp3ca Ppp3cb Prkar1b Prkar1a Nfkbia Vip Map3k1 Nfatc1 Egr2 Nfatc2 Rela Nfkb1 Plcg1 Prkacb Egr3 Vipr2 Chuk Myc PID_S1P_META_PATHWAY%MSIGDB_C2%PID_S1P_META_PATHWAY PID_S1P_META_PATHWAY Gnai2 Gnaq S1pr2 S1pr1 S1pr3 S1pr5 Sphk2 S1pr4 Abcc1 Gna11 Gnai3 Sphk1 Gnao1 Sgpl1 Sgpp1 Gnaz Gna13 Gna12 Gna14 Gnai1 Gna15 PID_ECADHERIN_STABILIZATION_PATHWAY%MSIGDB_C2%PID_ECADHERIN_STABILIZATION_PATHWAY PID_ECADHERIN_STABILIZATION_PATHWAY Vasp Rock1 Igf1r Igf1 Hgf Plekha7 Mgat3 Camsap3 Pvrl2 Met Myo6 Aqp3 Ctnnb1 Stx4a Exoc4 Ctnnd1 Lima1 Pip5k1c Epha2 Cdh1 Git1 Egf Arf6 Aqp5 Actn1 Exoc3 Kifc3 Efna1 Lpp Ctnna1 Nckap1 Nck1 Myl2 Abi1 Cyfip2 Rhoa Mllt4 Vcl Zyx Egfr Diap1 PID_IL12_2PATHWAY%MSIGDB_C2%PID_IL12_2PATHWAY PID_IL12_2PATHWAY Gzmb Sphk2 Il2ra Il2 Mapk14 Fasl Stat5a Mtor Fos Jak2 Ppp3r1 Nfkb2 Stat1 Stat3 Rela Nfkb1 Il1b Il2rg Cd4 Stat6 H2-Eb1 Il4 Ifng Il12b Cd247 Cd3d Ccr5 Stat4 Tyk2 Il12a Map2k6 Il12rb2 Cd3g Il18r1 Cd3e Il18 Il12rb1 Map2k3 Lck Cd8b1 Gzma Ppp3ca Ppp3cb Atf2 Gadd45g Relb B2m Rab7 Tbx21 Gadd45b Il18rap Ripk2 Ccl4 H2-Q10 Il1r1 Eomes Socs1 Nos2 Hlx Il2rb Cd8a PID_CXCR4_PATHWAY%MSIGDB_C2%PID_CXCR4_PATHWAY PID_CXCR4_PATHWAY Mlst8 Pdpk1 Stat5b Stat5a Mtor Pxn Cxcl12 Jak2 Bcar1 Cxcr4 Rictor Itch Ralb Ubqln1 Ptprc Rgs1 Stat1 Inpp5d Rhob Stat3 Rhoc Ptpn11 Pag1 Rhoa Grk6 Pten Vps4a Csk Itga11 Hgs Ssh1 Mapkap1 Itga10 Itga8 Itga9 Itga6 Itga7 Itga4 Pik3r5 Itga2 Rac1 Itga1 Plcb3 Gnai2 Pik3r6 Arrb2 Stat2 Pak1 Gnb1 Cd247 Cd3d Cd3g Cd3e Ptpn6 Hck Limk1 Dnm1 Pik3cg Gna13 Ptk2b Mmp9 Fgr Ptk2 Lyn Itgav Gng2 Plcb1 Plcb2 Itgb1 Foxo1 Arr3 Crk Akt1 Rap1b Itga5 Pik3cb Gnai3 Gnao1 Adrbk1 Gnaz Cd4 Itga3 H2-Eb1 Yes1 Src Gnb2l1 Vps4b Pik3ca Blk Bad Prkcz Pik3r3 Pik3r1 Lck Vav1 Pik3r2 Fyn Pik3cd Gnai1 HALLMARK_HEME_METABOLISM%MSIGDB_C2%HALLMARK_HEME_METABOLISM HALLMARK_HEME_METABOLISM Slc11a2 Cpox Car2 Hbb-bs Gde1 Psmd9 Slc30a1 Pcx Pigq Sidt2 Khnyn Gypc Adipor1 Sec14l1 Tmcc2 Synj1 Igsf3 Klf3 Blvra Atp6v0a1 Xpo7 Btrc Trim10 Ctns Klf1 Pdzk1ip1 Lmo2 Ackr1 Glrx5 Slc25a38 Hbb-bt Slc25a37 Nfe2 Foxo3 Kdm7a Aldh1l1 Tal1 H1f0 Kel Selenbp2 Mark3 Rap1gap Fn3k Narf Nek7 Slc4a1 Kat2b Slc2a1 Ccnd3 Ell2 Nfe2l1 Ctse Slc22a4 Ctsb Hba-x Hdgf Slc30a10 Icam4 Tns1 Tnrc6b Asns Ypel5 Slc7a11 Mboat2 Myl4 Usp15 Mkrn1 Btg2 Gata1 Urod Cast Fech Gapvd1 Abcg2 Lamp2 Fbxo7 Fbxo9 Trim58 Pqlc1 Nr3c1 Rhag Endod1 Hbq1a Tyr Bpgm Slc6a8 Rhd Htatip2 Map2k3 Slc6a9 Blvrb Spta1 Tcea1 Nudt4 Epor Alas2 Abcb6 Ezh1 Rbm5 Smox Ppox P4ha2 Rbm38 Dcaf10 Dcun1d1 Bsg Dcaf11 Ucp2 Lrp10 Arhgef12 Tfdp2 Fbxo34 Ranbp10 March2 Car1 Prdx2 Ccdc28a Lpin2 Riok3 Add1 Rcl1 Sdcbp Mgst3 Osbp2 Add2 Agpat4 Tspo2 Htra2 Cir1 Acsl6 Arl2bp Hagh Mpp1 Dmtn Rad23a Epb4.1 Cdr2 Clcn3 Aldh6a1 Bach1 Minpp1 Epb4.2 Cdc27 Hmbs Sptb Mxi1 Eif2ak1 Rnf19a Bcam Foxj2 Acp5 Uros Pgls Tfrc Cat Trak2 Optn Rnf123 Atg4a Xk Gmps Slc10a3 Gclc Mocos Alad Tmem9b Bmp2k Gclm Daam1 Bnip3l Ubac1 Tspan5 Hebp1 Mfhas1 Vezf1 Top1 Ank1 Ppp2r5b Ftcd Nnt Picalm Aqp3 Snca C3 E2f2 PID_GLYPICAN_1PATHWAY%MSIGDB_C2%PID_GLYPICAN_1PATHWAY PID_GLYPICAN_1PATHWAY Nrg1 Yes1 Src Blk Gpc1 Tgfb2 Slit2 Lama1 Serpinc1 Fgf2 Fgfr1 Lck Prnp Hck App Fyn Smad2 Tgfb1 Fgr Lyn Tgfb3 Vegfa Flt1 Tgfbr2 Tgfbr1 PID_FANCONI_PATHWAY%MSIGDB_C2%PID_FANCONI_PATHWAY PID_FANCONI_PATHWAY Chek1 Mre11a Sspo Hes1 Atm Rpa1 Fan1 2310003H01Rik Rad50 Rad1 Blm Fancd2 Brca2 Apitd1 Rad17 Wdr48 Usp1 Fancc Trex1 Rad9a Fanci Ube2t Atrip Fancm Fancl Topbp1 Hus1 Fancb H2afx Rpa2 Xrcc3 Fbxw11 C230052I12Rik Nbn Top3a Brip1 Rfc5 Rfc3 Brca1 Rfc4 Rfc2 Fanca Fancg Fancf Palb2 PID_FRA_PATHWAY%MSIGDB_C2%PID_FRA_PATHWAY PID_FRA_PATHWAY Ccna2 Il6 Cdkn2a Ep300 Fosl2 Junb Nfatc3 Fosl1 Nfatc1 Mmp1a Nfatc2 Lama3 Itgb4 Mmp2 Plaur Ccnd1 Jund Hmox1 Dmtf1 Usf2 Txlng Col1a2 Ccl12 Mgp Atf4 Nos3 Gja1 Thbd Dcn Lif Jun Plau Sp1 Mmp9 BIOCARTA_CTCF_PATHWAY%MSIGDB_C2%BIOCARTA_CTCF_PATHWAY BIOCARTA_CTCF_PATHWAY Mdm2 Tgfbr3 Tgfb2 Cdkn2a Pik3r1 Smad5 Cd79a Pik3cg Cd79b Pten Smad4 Smad1 Ppp2ca Mtor Tgfb1 Trp53 Cdkn1b Tgfb3 Pik3ca Myc Tgfbr2 Tgfbr1 BIOCARTA_AKT_PATHWAY%MSIGDB_C2%BIOCARTA_AKT_PATHWAY BIOCARTA_AKT_PATHWAY Ikbkb Akt1 Pik3r1 Foxo4 Ghr Foxo3 Casp9 Pik3cg Fasl Pdpk1 Nfkbia Ppp2ca Ikbkg Hsp90aa1 Rela Nfkb1 Pik3ca Chuk Ywhah Bad Foxo1 BIOCARTA_SARS_PATHWAY%MSIGDB_C2%BIOCARTA_SARS_PATHWAY BIOCARTA_SARS_PATHWAY Ldha Mapk14 Ldhb Ldhc Anpep Ckm Fbl Gpt Eif4e BIOCARTA_CTL_PATHWAY%MSIGDB_C2%BIOCARTA_CTL_PATHWAY BIOCARTA_CTL_PATHWAY Icam1 Itgal Prf1 Gzmb Fas B2m Cd247 Fasl Cd3d H2-Q10 Cd3g Cd3e Itgb2 PID_TNF_PATHWAY%MSIGDB_C2%PID_TNF_PATHWAY PID_TNF_PATHWAY Tab2 Ikbkb Txn1 Cyld Map4k5 Map4k4 Birc2 Birc3 Nsmaf Rffl Tnfaip3 Traf1 Map3k3 Madd Gnb2l1 Map4k3 Smpd2 Sqstm1 Adam17 Map3k5 Nrk Map4k2 Prkcz Tnik Tnf Tnfrsf1a Map2k7 Bag4 Tnfrsf1b Map2k3 Stat1 Prkci Traf2 Fadd Tradd Map3k1 Ripk1 Ikbkg Cav1 Casp8 Rela Smpd1 Tab1 Nfkb1 Chuk Map3k7 BIOCARTA_BAD_PATHWAY%MSIGDB_C2%BIOCARTA_BAD_PATHWAY BIOCARTA_BAD_PATHWAY Igf1r Adcy1 Igf1 Prkar2a Prkar2b Akt1 Bcl2 Pik3r1 Bax Kit Il3ra Rps6ka1 Bcl2l1 Prkar1b Pik3cg Prkar1a Kitl Prkacb Pik3ca Csf2rb2 Mapk1 Mapk3 Ywhah Bad PID_BETA_CATENIN_NUC_PATHWAY%MSIGDB_C2%PID_BETA_CATENIN_NUC_PATHWAY PID_BETA_CATENIN_NUC_PATHWAY Apc Smarca4 Tbl1x Neurog1 Axin2 Sspo Lef1 Igf2bp1 Mdfic Hdac2 Ywhaz Dvl3 Myf5 Ncoa2 Id2 Bcl9 Ctnnbip1 Camk4 Tcf7l1 Tcf7l2 Sp5 Tcf7 Tert Ctbp1 Mmp2 Sfn Cul1 Ywhae Ywhab Krt1 Pitx2 Ywhah Ywhag Cdkn2a Ep300 T Ctnnb1 Cdh1 Ccnd1 Myc Tnik Ccnd2 Cyr61 Kcnip4 Mitf Zcchc12 Hdac1 Tle4 Tle1 Ar Skp1a Tle2 Cacna1g mt-Co2 Ruvbl2 Tcf4 Cby1 Xpo1 Jun Hbp1 Myog Dkk1 Dkk4 Klf4 Incenp Aes Mmp9 Trrap Cdx1 Sall4 Cdx4 Tbl1xr1 Chd8 Vcan Snai2 Fgf4 Adcy7 Med12 PID_KIT_PATHWAY%MSIGDB_C2%PID_KIT_PATHWAY PID_KIT_PATHWAY Sos1 Gsk3b Map2k1 Shc1 Map2k2 Pdpk1 Stat5a Hras Jak2 Akt1 Grb10 Dok1 Mapk8 Sh2b2 Stat1 Foxo3 Stat3 Ptpn11 Pten Mapk3 Raf1 Ptpro Crebbp Matk Pik3c2b Pik3ca Spred1 Spred2 Bad Fer Grap2 Stap1 Map4k1 Gab1 Crkl Epo Mitf Tec Ptpn6 Pik3r1 Bcl2 Kit Vav1 Epor Sh2b3 Grb2 Kitl Lyn Socs1 Snai2 Cbl BIOCARTA_CYTOKINE_PATHWAY%MSIGDB_C2%BIOCARTA_CYTOKINE_PATHWAY BIOCARTA_CYTOKINE_PATHWAY Il6 Ifnb1 Il1a Il9 Ifna16 Lta Il5 Il10 Il16 Il15 Il4 Il13 Ifng Il12b Il2 Il17a Il12a Il18 Tnf BIOCARTA_CREB_PATHWAY%MSIGDB_C2%BIOCARTA_CREB_PATHWAY BIOCARTA_CREB_PATHWAY Sos1 Adcy1 Prkar2a Camk2a Prkar2b Creb1 Camk2b Prkca Camk2d Camk2g Rps6ka1 Mapk14 Hras Prkacb Pik3ca Akt1 Pik3r1 Grb2 Prkar1b Prkar1a Prkcb Mapk1 Rps6ka5 Mapk3 Rac1 BIOCARTA_MAPK_PATHWAY%MSIGDB_C2%BIOCARTA_MAPK_PATHWAY BIOCARTA_MAPK_PATHWAY Ikbkb Creb1 Rps6ka1 Shc1 Map2k1 Mapk14 Map2k2 Daxx Hras Braf Fos Mapk12 Mapk11 Mapkapk5 Tgfb2 Mapk13 Mapk8 Stat1 Traf2 Map3k14 Tradd Nfkbia Ripk1 Tgfb1 Rela Nfkb1 Tgfb3 Mapk1 Mapk3 Chuk Raf1 Rac1 Tgfbr1 Mapk7 Mknk2 Pak1 Map4k5 Mef2d Map4k4 Rapgef2 Araf Map3k2 Mknk1 Map3k3 Map4k3 Map2k6 Map3k5 Myc Map4k2 Mapk10 Map4k1 Map2k7 Cebpa Mapk9 Map3k11 Map2k3 Map2k4 Pak2 Rps6ka3 Grb2 Map2k5 Atf2 Jun Map3k8 Elk1 Map3k9 Map3k4 Sp1 Map3k1 Map3k6 Map3k12 Rps6ka2 Map3k13 Rps6ka4 Map3k10 Rps6kb2 Rps6ka5 Max Mapkapk3 Map3k7 Mapkapk2 Mef2c Mapk4 Mef2a Mapk6 BIOCARTA_ACE2_PATHWAY%MSIGDB_C2%BIOCARTA_ACE2_PATHWAY BIOCARTA_ACE2_PATHWAY Agt Col4a4 Col4a2 Col4a3 Agtr1a Ace2 Col4a1 Col4a5 Cma1 Col4a6 Agtr2 Ace BIOCARTA_PPARA_PATHWAY%MSIGDB_C2%BIOCARTA_PPARA_PATHWAY BIOCARTA_PPARA_PATHWAY Sra1 Prkar2a Prkar2b Ncor1 Pdgfa Nr1h3 Fabp1 Cd36 Prkca Stat5b Stat5a Prkacb Ncor2 Tnf Dusp1 Ehhadh Prkar1b Fat1 Cited2 Prkar1a Dut Mrpl11 Nfkbia Rxra Nr2f1 Hsp90aa1 Ppargc1a Apoa1 Apoa2 Rela Mapk1 Mapk3 Cpt1b Acox1 Me1 Hspa1a Hsd17b4 Ppara Crebbp Ep300 Lpl Rb1 Pik3ca Ins2 Myc Nr0b2 Pik3r1 Nrip1 Ncoa1 Jun Pik3cg Sp1 Prkcb Ptgs2 Nos2 Med1 BIOCARTA_EGFR_SMRTE_PATHWAY%MSIGDB_C2%BIOCARTA_EGFR_SMRTE_PATHWAY BIOCARTA_EGFR_SMRTE_PATHWAY Map2k1 Mapk14 Egfr Thrb Rxra Map3k1 Egf Zbtb16 Ncor2 Thra Rara HALLMARK_XENOBIOTIC_METABOLISM%MSIGDB_C2%HALLMARK_XENOBIOTIC_METABOLISM HALLMARK_XENOBIOTIC_METABOLISM Car2 Pcx Irf8 Tmem97 Tnfrsf1a Tgfb2 Rap1gap Ces1d Ets2 Tyr Blvrb Smox Serpine1 Lpin2 Vtn Fabp1 Cd36 Cyfip2 Gclc Jup Igf1 Epha2 Mt2 Il1r1 Esr1 Hmox1 Bcar1 Crp Vnn1 Hprt Comt Tat Tmbim6 Ddt Hgfac Gss Reg1 Upb1 Aldh3a1 Gsr Aqp9 Ugdh Entpd5 Slc6a6 Fmo3 Slc35d1 Psmb10 Arg1 Rbp4 Hrg Cbr1 Dcxr Bcat1 Acox3 Ppard Ddc Acox2 Pycr1 Aldh2 Fmo1 Maoa Leap2 Hsd11b1 Ssr3 Arpp19 Nmt1 Ndrg2 Fbp1 Atoh8 Cyb5a Nfs1 Arg2 Pemt Casp6 Ddah2 Pdk4 Aox1 Tpst1 Npc1 Gstt2 Cyp27a1 Csad Slc1a5 Fah Por Gcnt2 March6 Cda Adh1 Gabarapl1 Slc35b1 Slc6a12 Cyp2c55 Igfbp1 Cyp17a1 Cyp26a1 Id2 Ptgr1 Slc22a1 Hnf4a Abcd2 Tkfc Igfbp4 Kynu Fas Gstm4 Dhps Cyp1a1 Slc12a4 Adh5 Gckr Adh7 Lcat Acp1 Hacl1 Cndp2 Acp2 Pdlim5 Cyp1a2 Cyp2e1 Hes6 Cfb Plg Itih4 Ahcy Sar1b Ninj1 Pros1 Spint2 Slc46a3 Cat Ccl25 G6pc Upp1 Cyp4f15 Pgd Aldh9a1 Mpp2 Sertad1 Itih1 Fetub Gart Xdh Ap4b1 Pts Enpep Pgrmc1 Mbl2 Papss2 Shmt2 Serpina6 Atp2a2 Lonp1 Gch1 Tmem176b Acox1 Angptl3 Cyp2s1 Ech1 Cyp2j6 Apoe Acsm1 F11 Mthfd1 Crot Ttpa Dhrs1 F10 Akr1c18 Retsat Etfdh Fbln1 Kars Pink1 Dhrs7 Akr1c21 Gnmt Elovl5 Tdo2 Aco2 Abhd6 Idh1 Mccc2 Pmm1 Man1a Alas1 Ptges Hsd17b2 Gsta3 Ephx1 Nqo1 Asl Gad1 Bphl Ptgds Abcc3 Cdo1 Abcc2 Gsto1 HALLMARK_BILE_ACID_METABOLISM%MSIGDB_C2%HALLMARK_BILE_ACID_METABOLISM HALLMARK_BILE_ACID_METABOLISM Abca3 Abcg4 Klf1 Aldh8a1 Abca4 Nedd4 Abca1 Slc27a5 Akr1d1 Sult1b1 Abca9 Paox Amacr Pex26 Tfcp2l1 Bcar3 Aqp9 Cyp39a1 Npc1 Cyp27a1 Abcd2 Abcd3 Hsd3b7 Pex13 Acsl5 Hacl1 Gstk1 Acsl1 Sult2b1 Scp2 Abcd1 Atxn1 Ttr Cat Hsd17b11 Optn Nr1i2 Aldh9a1 Dhcr24 Gclm Rxra Apoa1 Pex11a Serpina6 Hsd17b4 Slc35b2 Fads2 Prdx5 Pex6 Abca2 Pex16 Ch25h Pex12 Hsd3b6 Soat2 Pnpla8 Ephx2 Pxmp2 Pex19 Isoc1 Fads1 Slc23a2 Cyp8b1 Aldh1a1 Idi1 Dio1 Crot Abcg8 Rbp1 Slc27a2 Nr0b2 Nr1h4 Lonp2 Phyh Retsat Nr3c2 Gnpat Slco1a4 Cyp7b1 Ar Hsd17b6 Pfkm Agxt Lck Bbox1 Gnmt Pipox Rxrg Bmp6 Idh2 Pecr Idh1 Efhc1 Mlycd Pex11g Lipe Pex1 Slc23a1 Abca8b Abca5 Dio2 Abca6 Slc29a1 Gc Nudt12 Pex7 Fdxr Hao1 Cyp7a1 Cyp46a1 Slc22a18 BIOCARTA_FEEDER_PATHWAY%MSIGDB_C2%BIOCARTA_FEEDER_PATHWAY BIOCARTA_FEEDER_PATHWAY Tpi1 Pygm Khk Lct Pgm2 Pygl Treh Mpi Hk1 ST_MYOCYTE_AD_PATHWAY%MSIGDB_C2%ST_MYOCYTE_AD_PATHWAY ST_MYOCYTE_AD_PATHWAY Apc Ryr1 Ephb2 Cfb Dlg4 Gnaq Akt1 Kat5 Itpr3 Kcnj3 Asah1 Dag1 Pitx2 Rho Adrb1 Cav3 Ptx3 Gnai1 Mapk1 Gast Kcnj5 Itpr1 Camp Rac1 Itpr2 Kcnj9 BIOCARTA_P35ALZHEIMERS_PATHWAY%MSIGDB_C2%BIOCARTA_P35ALZHEIMERS_PATHWAY BIOCARTA_P35ALZHEIMERS_PATHWAY Capns1 Gsk3b Cdk5 Ppp2ca Capn1 Csnk1a1 Cdk5r1 Capns2 App Csnk1d BIOCARTA_TEL_PATHWAY%MSIGDB_C2%BIOCARTA_TEL_PATHWAY BIOCARTA_TEL_PATHWAY Igf1r Akt1 Bcl2 Prkca Tnks Kras Terf1 Polr2a Tep1 Xrcc5 Tert Egfr Ppp2ca Hsp90aa1 Xrcc6 Rb1 Trp53 Myc HALLMARK_IL6_JAK_STAT3_SIGNALING%MSIGDB_C2%HALLMARK_IL6_JAK_STAT3_SIGNALING HALLMARK_IL6_JAK_STAT3_SIGNALING Csf2 Cd36 Lepr Fas Il2ra Pim1 Ptpn1 Csf2ra Csf2rb2 Hmox1 Tnf Tnfrsf1a Tnfrsf1b Stat1 Stat3 Ptpn11 Tgfb1 Il10rb Il9r Cntfr Osmr Itga4 Pik3r5 Il6st Il1b Il1r2 Il2rg Il15ra Il6 Crlf2 Cxcl11 Cd9 Cxcl10 Irf9 Ifnar1 Dntt Cd44 Il17ra Stat2 Csf1 Reg1 Cxcl13 Ebi3 Ltb Tlr2 Il4ra Il3ra Myd88 Il17rb Bak1 Inhbe Csf3r Cd14 Ltbr Tnfrsf12a Cxcl3 Itgb3 Tyk2 Tnfrsf21 Cxcl9 Ifngr1 Ifngr2 Cxcl2 Pf4 Acvr1b Il18r1 A2m Irf1 Hax1 Il12rb1 Ccl7 Stam2 Ptpn2 Ccr1 Acvrl1 Il7 Pdgfc Cd38 Il13ra1 Socs3 Grb2 Jun Map3k8 Il1r1 Socs1 Cbl PID_LIS1_PATHWAY%MSIGDB_C2%PID_LIS1_PATHWAY PID_LIS1_PATHWAY Dab1 Iqgap1 Katna1 Cdk5r2 Vldlr Reln Cdk5 Cdk5r1 Map1b Pla2g7 Dync1h1 Dcx Pafah1b2 Ywhae Pafah1b3 Lrpap1 Rhoa Nudc Pafah1b1 Ndel1 Clip1 Ppp2r5d Abl1 Rac1 BIOCARTA_CASPASE_PATHWAY%MSIGDB_C2%BIOCARTA_CASPASE_PATHWAY BIOCARTA_CASPASE_PATHWAY Prf1 Gzmb Apaf1 Dffa Lmnb1 Xiap Dffb Parp1 Birc2 Birc3 Casp6 Casp7 Casp3 Casp9 Casp1 Casp8 Arhgdib Lmna Casp2 Casp4 Lmnb2 PID_MAPK_TRK_PATHWAY%MSIGDB_C2%PID_MAPK_TRK_PATHWAY PID_MAPK_TRK_PATHWAY Mapk7 Creb1 Map3k2 Rps6ka1 Map2k1 Mapk14 Rit1 Rit2 Hras Trpv1 Egr1 Prkcd Ehd4 Braf Srf Map2k6 Fos Cdk5 Cdk5r1 Map2k3 Ntf3 Rap1b Rap1a Kras Map2k5 Elk1 Nras Rps6ka5 Mapk1 Mapk3 Mapkapk2 Mef2c Raf1 PID_RHOA_PATHWAY%MSIGDB_C2%PID_RHOA_PATHWAY PID_RHOA_PATHWAY Rock1 Acta1 Pip5k1c Srf Map2k6 Rdx F2rl2 Itgb1 Rock2 Fos Prkcz Mapk12 Tln1 Slc9a3 Cyr61 Slc9a1 Cit Ezr Pard6a Sh3gl2 Msn Scai Map2k4 Map2k3 Pkn2 Pip5k1b Myl2 Mapk8 Limk1 Mkl1 Limk2 Ppp1r12a Pkn1 Rhoa Atf2 Jun Pten Vcl Diap1 Cdkn1b Pld2 Pld1 Pip5k1a BIOCARTA_CELLCYCLE_PATHWAY%MSIGDB_C2%BIOCARTA_CELLCYCLE_PATHWAY BIOCARTA_CELLCYCLE_PATHWAY Ccnd2 Ccnd3 Cdkn2c Cdc25a Cdkn2a Cdkn2b Ccne1 Ccnh Cdk4 E2f1 Tfdp1 Cdkn1a Cdk6 Ccna1 Rb1 Cdkn1b Cdk7 Ccnd1 Cdk2 Rbl1 Cdk1 BIOCARTA_LYM_PATHWAY%MSIGDB_C2%BIOCARTA_LYM_PATHWAY BIOCARTA_LYM_PATHWAY Icam1 Sell Itgal Pecam1 Il1a Cd34 Itgb1 Itga4 Itgb2 Vcam1 PID_IL6_7_PATHWAY%MSIGDB_C2%PID_IL6_7_PATHWAY PID_IL6_7_PATHWAY Il6st Sos1 Crp Il6 Jak1 Lmo4 Bcl2l1 Mapk14 Cebpb Junb Prkcd Tyk2 Tnfsf11 Gab2 Map2k6 Pik3ca Pias1 Fos Foxo1 Fgg Myc Jak2 A2m Irf1 Gab1 Mapk11 Mitf Akt1 Mcl1 Map2k4 Pik3r1 Hck Vav1 Pias3 Stat1 Stat3 Ptpn11 Socs3 Grb2 Timp1 Jun Lbp Hsp90b1 Il6ra Ptpre Rac1 BIOCARTA_TRKA_PATHWAY%MSIGDB_C2%BIOCARTA_TRKA_PATHWAY BIOCARTA_TRKA_PATHWAY Shc1 Sos1 Prkcb Hras Akt1 Pik3r1 Plcg1 Ntrk1 Pik3ca Prkca Ngf Grb2 BIOCARTA_AHSP_PATHWAY%MSIGDB_C2%BIOCARTA_AHSP_PATHWAY BIOCARTA_AHSP_PATHWAY Alad Cpox Alas1 Hbb-bs Uros Urod Gata1 Fech Hba-a1 Alas2 Hmbs Hbb-bt BIOCARTA_TNFR1_PATHWAY%MSIGDB_C2%BIOCARTA_TNFR1_PATHWAY BIOCARTA_TNFR1_PATHWAY Dffa Dffb Pak1 Cradd Sptan1 Madd Rb1 Arhgdib Lmna Casp2 Lmnb2 Tnf Tnfrsf1a Bag4 Prkdc Map2k4 Lmnb1 Pak2 Mapk8 Parp1 Casp3 Traf2 Jun Fadd Map3k1 Tradd Ripk1 Casp8 Map3k7 BIOCARTA_SHH_PATHWAY%MSIGDB_C2%BIOCARTA_SHH_PATHWAY BIOCARTA_SHH_PATHWAY Prkar2a Prkar2b Gsk3b Dyrk1b Sufu Gli1 Dyrk1a Gli2 Gli3 Shh Ptch1 Prkar1b Prkar1a Smo Prkacb BIOCARTA_VDR_PATHWAY%MSIGDB_C2%BIOCARTA_VDR_PATHWAY BIOCARTA_VDR_PATHWAY Kat2b Crebbp Rxra Hdac1 Ncor1 Tsc2 Ncoa2 Carm1 Ep300 Ncoa3 Ncoa1 Med1 BIOCARTA_EPHA4_PATHWAY%MSIGDB_C2%BIOCARTA_EPHA4_PATHWAY BIOCARTA_EPHA4_PATHWAY Selp Acta1 Lyn Ephb1 L1cam Rap1b Epha4 Itgb1 Fyn Itga1 PID_BMP_PATHWAY%MSIGDB_C2%PID_BMP_PATHWAY PID_BMP_PATHWAY Sostdc1 Ahsg Ppm1a Bmp2 Tab2 Gsk3b Nog Bmpr1b Cer1 Smad5 Smad4 Smad1 Zfyve16 Xiap Smurf2 Bmp6 Smurf1 Ski Fst Nup214 Chrd Bambi Ctdspl Ctdsp1 Grem1 Smad6 Smad7 Tab1 Ppp1ca Smad9 Bmpr2 Rgma Mapk1 Rgmb Map3k7 Ppp1r15a Hfe2 Bmpr1a Bmp4 Bmp7 BIOCARTA_RB_PATHWAY%MSIGDB_C2%BIOCARTA_RB_PATHWAY BIOCARTA_RB_PATHWAY Chek1 Cdc25c Myt1 Cdc25b Atm Cdk4 Mapk14 Rb1 Trp53 Wee1 Cdk2 Ywhah Cdk1 BIOCARTA_41BB_PATHWAY%MSIGDB_C2%BIOCARTA_41BB_PATHWAY BIOCARTA_41BB_PATHWAY Ikbkb Tnfrsf9 Mapk8 Map4k5 Il4 Ifng Atf2 Traf2 Jun Il2 Mapk14 Nfkbia Map3k1 Rela Nfkb1 Map3k5 Chuk BIOCARTA_BCELLSURVIVAL_PATHWAY%MSIGDB_C2%BIOCARTA_BCELLSURVIVAL_PATHWAY BIOCARTA_BCELLSURVIVAL_PATHWAY Akt1 Pik3r1 Xiap Dpf2 Casp7 Cct4 Casp3 Zbtb7a Pik3cg Birc5 Mtor Pik3ca Jund Itgb1 Fos Itga1 HALLMARK_REACTIVE_OXIGEN_SPECIES_PATHWAY%MSIGDB_C2%HALLMARK_REACTIVE_OXIGEN_SPECIES_PATHWAY HALLMARK_REACTIVE_OXIGEN_SPECIES_PATHWAY Glrx2 Atox1 Vimp Lamtor5 Sbno2 Srxn1 Egln2 Prdx6 Txn1 Pdlim1 G6pdx Hmox2 Gsr Prdx1 Prdx4 Scaf4 Ndufb4 Stk25 Ipcef1 Junb Ppp2r4 Oxsr1 Fes Ndufa6 Sod2 Cat Prnp Abcc1 Gclc Hhex Gpx4 Txnrd1 Gclm Gpx3 Pfkp Ercc2 Mgst1 Txnrd2 Nqo1 Mbp Msra Lsp1 Mpo Ndufs2 Prdx2 Ftl1 Glrx BIOCARTA_CERAMIDE_PATHWAY%MSIGDB_C2%BIOCARTA_CERAMIDE_PATHWAY BIOCARTA_CERAMIDE_PATHWAY Tnfrsf1a Map2k4 Bcl2 Bax Mapk8 Nsmaf Aifm1 Traf2 Map2k1 Fadd Map3k1 Tradd Ripk1 Casp8 Smpd1 Rela Nfkb1 Mapk1 Mapk3 Bad Raf1 HALLMARK_HYPOXIA%MSIGDB_C2%HALLMARK_HYPOXIA HALLMARK_HYPOXIA Klf6 Klf7 Grhpr Gpi1 Akap12 Gbe1 Slc25a1 Gys1 Isg20 Phkg1 Srpx Ackr3 Plin2 Wisp2 Ids Chst2 Galk1 Lxn Pnrc1 Inha Pim1 Pfkl Pgm1 Pgf Csrp2 Ext1 Ptrf Lalba Tiparp Atf3 Anxa2 Prkcdbp Angptl4 Fos Hk2 Bgn Btg1 Sdc2 Sdc3 Brs3 Sdc4 Vhl Gck Dtna Rora Lox Ndrg1 Zfp36 Has1 Jmjd6 Ccng2 Foxo3 Tgm2 Gaa Stc1 Large Myh9 Hspa5 Slc2a3 Selenbp2 Stc2 Zfp292 Efna3 Ppfia4 Slc2a5 Kdelr3 Xpnpep1 Hs3st1 Hoxb9 Tgfbi Pam Slc2a1 Ets1 Tpbg Ppp1r3c Eno1b Hdlbp Mt1 Tpst2 Adora2b Nr3c1 Cdkn1a P4ha2 Edn2 Pkp1 Serpine1 Vldlr Sap30 Mxi1 Dusp1 Cited2 Bnip3l Cav1 Cdkn1b Vegfa B4galnt2 Tpi1 Fam162a Pygm Il6 Gpc3 Gpc4 Klhl24 Plac8 Pgm2 Ccrn4l F3 Atp7a Ndst2 Pgam2 Ndst1 S100a4 Ampd3 Chst3 Cp Hk1 Ncan Fosl2 Pgk1 Tmem45a Tes Hexa Siah2 Ugp2 Efna1 Kif5a Gpc1 Pfkfb3 Ier3 Scarb1 Kdm3a Pklr Cdkn1c Bcan Ero1l Nagk Aldob Stbd1 Wsb1 Aldoa Bhlhe40 Dpysl4 Ddit3 Eno2 Eno1 Jun Adm Pdgfb Mt2 Car12 Ilvbl Mif Eno3 Maff Slc37a4 Tktl1 Gapdhs B3galt6 Pck1 P4ha1 Ankzf1 Ldha Ldhc Prkca Ddit4 Rbpj Hmox1 Cxcr4 Dcn Nedd4l Rragd Ppargc1a Tgfb3 Ppp1r15a Ctgf Slc6a6 Tnfaip3 Irs2 Fbp1 Bcl2 Casp6 Egfr Pfkp Map3k1 Glrx Gcnt2 Igfbp1 Sult2b1 Pdk1 Nfil3 Col5a1 Prdx5 Igfbp3 Errfi1 Plaur Pdk3 Aldoc Cyr61 PID_TXA2PATHWAY%MSIGDB_C2%PID_TXA2PATHWAY PID_TXA2PATHWAY Icam1 Gnb5 Prkca Vcam1 Mapk14 Egf Prkaca Syk Arr3 Nos3 Mapk11 Gnaq Akt1 Gna11 Tgm2 Rhoa Adrbk1 Pik3r5 Rac1 Prkg1 Ptgir Rock1 Ptgdr Prkch Prkce Gnai2 Adrbk2 Prkcq Slc9a3r1 Pik3r6 Sele Arrb2 Rab11a Gnb1 Yes1 Src Prkcd Tbxa2r Blk Prkcz Lck Hck Dnm1 Fyn Prkcg Pik3cg Egfr Arhgef1 Prkcb Gna13 Fgr Gna12 Lyn Gna14 Gng2 Gna15 Plcb2 NABA_SECRETED_FACTORS%MSIGDB_C2%NABA_SECRETED_FACTORS NABA_SECRETED_FACTORS Csf2 Osm Inha Pgf Angptl4 Ccl12 Tgfb2 Gdnf Ntf3 Wnt16 Cxcl11 Cxcl10 Csf1 Cxcl13 Ebi3 Ltb Inhbe Cxcl3 Cxcl9 Cxcl2 Pf4 Ccl7 Fgf22 Il7 Pdgfc Insl5 Fgf16 Pdgfd Kitl Wnt9b Wnt9a Nrg3 Nrg4 Megf8 Ereg S100g Csf3 Il1a Gdf9 Hgf S100z Pdgfa Gdf5 S100b Megf9 Gdf2 Gdf3 Gdf6 Lep Gdf7 Ism2 Il2 Wnt8a Fasl Tpo Wnt8b Tnfsf12 Tnfsf15 Tnfsf14 Ism1 Nodal Bdnf Fgf18 Tnfsf18 Wnt7b Fgf17 Fgf14 Tnf Fgf15 Fgf11 Wnt7a Fgf10 Fgf13 Fgf12 Insl6 Vwc2l Angptl7 Angptl6 Tchhl1 Angptl2 Angptl1 Insl3 Pik3ip1 Fgf23 Mdk Fgf20 Fgf21 Il17b Ptn Tnfsf13b Il17d Il17c Flt3l Tgfb1 Il17f Ccl22 Ccl28 Vegfa Tnfsf4 Ccl24 Lefty2 Ccl20 Tnfsf13 Tnfsf8 Frzb Il1b Il6 Igf1 Il1f5 Il1f6 Il24 Il20 Il5 S100a4 Il25 Ccl11 Il4 Il1f8 Il1f9 Cxcl14 Il17a Ctf1 Fgfbp1 Fgfbp3 Vegfb Tnfsf11 Vegfc Fgf1 Fgf3 Fgf5 Fgf6 Fgf7 Ins2 Fgf8 Fgf9 Il34 Megf6 Cbln1 Ntf5 Cbln2 Bmp3 Bmp5 Wfikkn2 Wfikkn1 Vwc2 Areg Amh Il11 Bmp6 Cbln3 Cbln4 Brinp2 Il19 Nrtn Artn Zfp91 Nrg2 Pdgfb Crhbp Brinp3 Flg2 Il1rn Ccl4 Bmp8a Eda Rptn Figf Ifne Ifnk Megf10 Megf11 Wnt1 Prl Egf Cxcl12 Lif Clcf1 Tnfsf10 Chrdl2 Scube3 Wnt5b Wnt5a S100a9 Tgfb3 S100a8 Crnn Scube1 S100a5 S100a3 Wif1 S100a6 Epgn Cxcl5 Xcl1 Mstn Ifnb1 Cxcl1 S100a1 Tchh Hgfac Cx3cl1 Gdf15 Iltifb Gdf10 Cntf Tgfa Hhip Btc Wnt3a Ifng Sfrp5 Bmp15 Il12b Wnt2b Il1f10 Gdf11 Sfrp1 Sfrp2 Sfrp4 Il12a Egfl6 Egfl7 Crlf3 Crlf1 Bmp10 Hbegf Il18 Egfl8 Thpo Wnt10b Wnt10a Ccl1 Dhh Epo Il23a Mst1 Hcfc2 Hcfc1 S100a14 Inhbc S100a13 Pspn Lefty1 Ccl5 Ccl2 Ccl3 Wnt3 Wnt11 S100a16 Wnt2 Inhbb S100a10 Inhba Ccbe1 Fstl3 Fstl1 Wnt6 Igf2 Ppbp Ihh Ccl17 Wnt4 Bmp2 Angpt2 Angpt4 Angpt1 Fgf2 Ccl25 Fst Chrd Bmp4 Angptl3 Bmp7 S100a11 Nrg1 Il9 Ifna16 Lta Il10 Il16 Il15 Shh Il13 Fgf4 Ngf SA_TRKA_RECEPTOR%MSIGDB_C2%SA_TRKA_RECEPTOR SA_TRKA_RECEPTOR Sos1 Akt3 Akt1 Akt2 Ngfr Rhoa Grb2 Pik3cd Map2k1 Cdkn1a Shc1 Map2k2 Elk1 Hras Ntrk1 Pik3ca Ngf BIOCARTA_WNT_PATHWAY%MSIGDB_C2%BIOCARTA_WNT_PATHWAY BIOCARTA_WNT_PATHWAY Apc Axin1 Lef1 Hdac1 Crebbp Gsk3b Fzd1 Wnt1 Tle1 Dvl1 Smad4 Ctnnb1 Nlk Ctbp1 Btrc Ppp2ca Csnk1a1 Tab1 Ppard Ccnd1 Map3k7 Csnk1d Myc Wif1 HALLMARK_FATTY_ACID_METABOLISM%MSIGDB_C2%HALLMARK_FATTY_ACID_METABOLISM HALLMARK_FATTY_ACID_METABOLISM Ldha Cpox Car2 Grhpr Bmpr1b Blvra Setd8 Fasn Nbn Ywhah Aqp7 Vnn1 Gcdh Hsph1 Bckdhb Gad2 Metap1 Ptprg Prdx6 Cryz Acadl Hmgcs2 Odc1 Aldh3a1 Echs1 Acadm Acads Ugdh Dld Fh1 Slc22a5 BC089597 Adipor2 Rap1gds1 Idh3g Idh3b Urod Hpgd Ube2l6 Cbr1 Gstz1 Ostc D2hgdh Ncaph2 Cyp4a32 Apex1 Nthl1 Eci1 Aldh3a2 Fmo1 Maoa G0s2 Hadh Sucla2 Hsdl2 Glul Hccs Acsm3 Adsl S100a10 Cpt1a Acot2 Adh1 Mgll Gabarapl1 Hadhb Sms Acadvl Sdhd Sdha Il4i1 Fabp1 Sdhc Cd36 Aoc3 Mdh1 Dlst Mdh2 Cyp1a1 Adh7 Acsl4 Acsl5 Acot8 Acsl1 Auh Pdha1 Gpd2 H2afz Mcee Uros Cidea Lgals1 Cd1d2 Serinc1 Hsd17b11 Ccdc58 Pdhb Cpt2 Erp29 Cel Hibch Aldh9a1 Inmt Crat Fabp2 Ehhadh Reep6 Ltc4s Alad Dhcr24 Trp53inp2 Cbr3 Hmgcl Acss1 Decr1 Pts Hsp90aa1 Pcbd1 Aadat Acaa2 Psme1 Suclg1 Car6 Car4 Hsd17b10 Me1 Gpd1 Acox1 Suclg2 Cyp4a12b Ppara Hsd17b4 Ech1 Acaa1a Acat2 Hao2 Eci2 Nsdhl Aldh1a1 Idi1 Retsat Etfdh Rdh11 Hsd17b7 Elovl5 Tdo2 Aldoa Aco2 Idh1 Mlycd Eno2 Ephx1 Mif Eno3 Bphl Gapdhs HALLMARK_ALLOGRAFT_REJECTION%MSIGDB_C2%HALLMARK_ALLOGRAFT_REJECTION HALLMARK_ALLOGRAFT_REJECTION Lcp2 Eif3j2 Mrpl3 Srgn Ikbkb Irf4 Cd74 Rps9 Ly86 Tlr6 Tlr3 Tlr1 Cd80 Igsf6 Eif5a Fcgr2b Dars Nlrp3 Cd79a Ube2n Cd96 Trat1 Gcnt1 Was St8sia4 Irf8 Galnt1 Gpr65 Hdac9 Apbb1 Flna Ache Rpl39 Ncr1 Jak2 Gbp2 Wars Ccl12 Rps19 Tgfb2 Lif Ptprc Stat1 Ly75 Degs1 Eif4g3 Rars Csk Acvr2a Krt1 Cd86 Aars Glmn Eif3d Capg Irf7 H2-DMa H2-Ob H2-Oa Eif3a Ccnd3 Cdkn2a Csf1 Cxcl13 Ets1 Ltb Tlr2 Cd40lg Elane Ifng Il12b Spi1 Psmb10 Cd247 Cd3d Ccr5 Stat4 Il12a Cxcl9 Ifngr1 Bcat1 Ifngr2 Cd3g Pf4 Cd3e Il18 Il12rb1 Ccl7 Tap2 Ctss F2r Tap1 Ccr1 Cd2 Fyb Il7 Icosl Crtam Ptpn6 Cd7 Hcls1 Elf4 H2-Aa Cartpt Abce1 Ccl5 Il27ra Ccl2 Cfp Tapbp Prkcg Itk C2 Stab1 Egfr H2-M3 Inhbb Prkcb Ccr2 Klrd1 Mmp9 Inhba Dyrk3 Fgr Cd47 Lyn Sit1 Brca1 Socs5 H2-DMb2 Ncf4 Map3k7 Mtif2 Thy1 Icam1 Itgal Prf1 Gzmb Ereg Fas Il2ra Bcl10 Il2 Fasl Itgb2 Tnf Cd40 F2 Cxcr3 Hif1a Nme1 Akt1 Cd1d2 Abi1 Bcl3 Traf2 Mbl2 Tgfb1 Ccl22 Il1b Cd4 Il2rg Il6 Il9 Il10 Il16 Il4ra Ccl11 Il15 Il13 Il4 Ifnar2 Map4k1 Ccnd2 Nck1 Cd8b1 Lck Il11 Gzma Ube2d1 Zap70 Timp1 Npm1 B2m Il18rap Ripk2 Ccl4 H2-Q10 Socs1 Nos2 Il2rb Cd8a BIOCARTA_BARRESTIN_SRC_PATHWAY%MSIGDB_C2%BIOCARTA_BARRESTIN_SRC_PATHWAY BIOCARTA_BARRESTIN_SRC_PATHWAY Adcy1 Arrb1 Hck Dnm1 Gnb1 Map2k1 Map2k2 Src Hras Gngt1 Mapk1 Mapk3 Plcb1 Raf1 HALLMARK_MYOGENESIS%MSIGDB_C2%HALLMARK_MYOGENESIS HALLMARK_MYOGENESIS Ryr1 Myh7 Pcx Rit1 Actc1 Svil Ckm Dtna Nos1 Chrng Sorbs1 Gaa Large Myh9 Stc2 Ppfia4 Myl4 Ppp1r3c Cacng1 Rb1 Slc6a8 Myl7 Myl2 Mylk Cdkn1a Myf6 Itgb5 Camk2b Cd36 Chrnb1 Col4a2 Chrna1 Mapk12 Bdkrb2 Tnni1 Sphk1 Gnao1 Tgfb1 Cav3 Pygm Igf1 Hdac5 Pgam2 Ctf1 Kifc3 Gsn Pfkm Prnp App Bhlhe40 Gadd45b Eno3 Tsc2 Foxo4 Dmd Notch1 Itgb4 Ache Psen2 Itga7 Mef2d Hbegf Gpx3 Lsp1 Mef2c Mef2a Bag1 Gja5 Erbb3 Vipr1 Cox7a1 Ablim1 Acta1 Ptgis Ncam1 Tnnc2 Cryab Pick1 Ephb3 Ckmt2 Pvalb Cox6a2 Tnnc1 Itgb1 Adcy9 Acsl1 Speg Mylpf Tagln Myh4 Myh8 Myh3 Myh2 Schip1 Myh1 Ifrd1 Fgf2 Sspn Mybpc3 Wwtr1 Mybph Hspb8 Myl6b Hspb2 Atp2a1 Crat Mb Akt2 Sh3bgr Col6a3 Fst Col6a2 Hrc Sgcd Sgca Col3a1 Tnnt1 Tnnt2 Tnnt3 Sgcg Fdps Syngr2 Bin1 Pde4dip Sorbs3 Cacna1h Cdh13 Csrp3 Ocel1 Sparc Fxyd1 Kcnh2 Igfbp7 Agl Spdef Smtn Ptp4a3 Dapk2 Cfd Scd1 Aplnr Eif4a2 Plxnb2 Tead4 Adam12 Igfbp3 Efs Klf5 Mapre3 Sptan1 Ak1 Sod3 Ldb3 Agrn Col15a1 Fhl1 Tnni2 Tpd52l1 Flii St5 Clu Tcap Actn2 Aebp1 Pkia Actn3 Ankrd2 Dmpk Ckb Lpin1 Myoz1 Mras Apod Myh11 Casq2 Casq1 Atp6ap1 Lama2 Myom1 Myom2 Myog Reep1 Fkbp1b Sirt2 Myo1c Cnn3 Sh2b1 Nqo1 Tpm2 Kcnh1 Gabarapl2 Des Col1a1 Myl1 Myl3 Tpm3 Fabp3 NABA_CORE_MATRISOME%MSIGDB_C2%NABA_CORE_MATRISOME NABA_CORE_MATRISOME Srpx Wisp2 Col2a1 Bgn Reln Igfbp2 Tgfbi Fga Fgb Fgg Col1a2 Ambn Bmper Vtn Col13a1 Svep1 Abi3bp Ndnf Aspn Col14a1 Lgi4 Lama4 Lgi3 Fbln7 Lgi2 Col17a1 Lgi1 Impg2 Lama5 Dmp1 Impg1 Srpx2 Col4a4 Fbln5 Igsf10 Col4a2 Fbln2 Col4a3 Podn Col4a1 Cilp2 Epyc Mfap1b Vwf Adipoq Ush2a Ncan Slit2 Lama1 Bcan Col4a5 Col4a6 Ibsp Col19a1 Zp3 Srgn Zp2 Sspo Ecm1 Vwa3a Tinag Oit3 Rspo2 Rspo1 Lamc3 Ecm2 Creld1 Creld2 Pcolce Rspo3 Lamc2 Igfbp6 Rspo4 Lamc1 Tsku Fgl1 Tnn Fbn1 Lama3 Fras1 Tnr Col18a1 Fgl2 Col16a1 Esm1 Tnc Otog Mgp Thsd4 Col22a1 Lum Tnfaip6 Dcn Gldn Col11a1 Gas6 Col11a2 Chad Omd Papln Fbn2 Col12a1 Colq Tinagl1 Fndc1 Prg2 Prg3 Ltbp1 Bsph1 Crim1 Ltbp4 Ltbp2 Ltbp3 Tectb Egflam Col26a1 Tnxb Fndc8 Fndc7 Wisp1 Ctgf Npnt Vwa5b2 Col20a1 Col24a1 Ogn Vwce Smoc2 Mepe Igfbpl1 Smoc1 Rangap1 Podnl1 Kera Pxdn Hspg2 Col10a1 Nell2 Nell1 Ntng1 Emilin1 Emilin3 Lrg1 Pcolce2 Emilin2 Dmbt1 Col28a1 Igfbp5 Col8a2 Efemp2 Ddx26b Zpld1 Efemp1 Vwde Cilp Col9a1 Col9a2 Col5a3 Col5a2 Vwa5a Col8a1 Prelp Col9a3 Mfap5 Mfap4 Mfap2 Ntn1 Otol1 Nyx Ntn4 Ntn5 Thbs2 Thbs1 Igfals Mfge8 Mfap3 Thbs4 Optc Thbs3 Lamb3 Sparcl1 Zp1 Lamb1 Edil3 Spp1 Cdcp2 Lamb2 Igfbp1 Igfbp4 Fn1 Col6a3 Col6a2 Col3a1 Col23a1 Matn1 Col7a1 Emid1 Sparc Dpt Col6a6 Coch Igfbp7 Col6a1 Col5a1 Cthrc1 Sbspon Slit1 Comp Sned1 Slit3 Vwa5b1 Tecta Crispld1 Col25a1 Igfbp3 Crispld2 Amelx Hapln2 Eln Hapln1 Hapln4 Hapln3 Agrn Nid1 Col15a1 Nid2 Matn3 Matn2 Vit Matn4 Fmod Spon1 Spon2 Cyr61 Aebp1 Nov Postn Mmrn2 Vwa1 Vwa2 Fbln1 Dspp Spock2 Mmrn1 Vwa7 Spock1 Tbc1d24 Col27a1 Vwa9 Spock3 Lama2 Col1a1 Vcan Kcp PID_NFKAPPAB_CANONICAL_PATHWAY%MSIGDB_C2%PID_NFKAPPAB_CANONICAL_PATHWAY PID_NFKAPPAB_CANONICAL_PATHWAY Tnfrsf1a Sspo Ikbkb Atm Cyld Birc2 Prkca Xpo1 Bcl10 Tnfaip3 Traf6 Nod2 Nfkbia Ikbkg Ripk2 Rela Erc1 Nfkb1 Malt1 Ube2d3 Ran Chuk Tnf PID_PDGFRB_PATHWAY%MSIGDB_C2%PID_PDGFRB_PATHWAY PID_PDGFRB_PATHWAY Sos1 Ppp2r2b Eps8 Actn4 Arap1 Ywhaz Ksr1 Slc9a3r2 Myocd Usp6nl Dnm2 Prkca Sipa1 Sla Arhgap35 Rab4a Shc1 Map2k1 Map2k2 Stat5b Stat5a Hras Ptpn1 Braf Jund Fos Sfn Jak2 Bcar1 Ptprj Grb10 Dok1 Stat1 Ywhae Stat3 Rhoa Pag1 Ptpn11 Pten Dock4 Pla2g4a Csk Ywhab Nras Mapk1 Mapk3 Ywhah Ywhag Pik3r5 Raf1 Rac1 Prkce Pik3r6 Slc9a3r1 Pak1 Itgb3 Srf Myc Map2k7 Gab1 Brk1 Ptpn2 Baiap2 Hck Arhgdia Pik3cg Rab5a Elk1 Ppp2ca Ppp2r1a Lrp1 Fgr Lyn Itgav Cbl Abl1 Pdgfrb Pin1 Tagln Iqgap1 Crk Nckap1 S1pr1 Rapgef1 Mapk8 Rap1b Abi1 Rap1a Cyfip2 Pik3cb Sphk1 Mllt4 Arpc5 Wasf2 Arpc2 Arpc3 Arpc4 Cttn Actr3 Actr2 Arpc1b Vav2 Rasa1 Yes1 Src Prkcd Eif2ak2 Plcg1 Pik3ca Blk Mapk10 Wasl Mapk9 Nck2 Pik3r3 Map2k4 Pik3r1 Rps6ka3 Nck1 Lck Pik3r2 Kras Fyn Grb2 Pik3cd Jun Pdgfb HALLMARK_INTERFERON_ALPHA_RESPONSE%MSIGDB_C2%HALLMARK_INTERFERON_ALPHA_RESPONSE HALLMARK_INTERFERON_ALPHA_RESPONSE Sell Cd74 Isg20 Rsad2 Casp1 Ifi35 Ifih1 Gbp3 Trafd1 Gbp2 Wars Elf1 Casp8 Psme1 Irf7 Usp18 Fam46a Psmb9 Psmb8 Cxcl11 Parp14 Cxcl10 Samd9l Irf9 Parp12 Lap3 Isg15 Stat2 Csf1 Irf2 Mov10 Tmem140 Oasl1 Ly6e Il4ra Il15 Txnip Cmtr1 Rtp4 Lamp3 Uba7 Ube2l6 Eif2ak2 Trim12c Pnpt1 Ifi44 Bst2 Lgals3bp Ccrl2 Oas1g Irf1 Batf2 Slc25a28 Parp9 Ncoa7 Sp110 Cmpk2 Tap1 Ddx60 C1s2 Il7 Cnp Helz2 Ifi30 Ifit3b Trim25 Trim21 Dhx58 Mvb12a Procr Trim26 Psme2 Adar B2m Nmi Rnf31 Tdrd7 Nub1 Ripk2 Gmpr Trim14 Cd47 Plscr1 Epsti1 Ogfr Ifi27 Herc6 Ifitm3 Ifitm2 Lpar6 Psma3 Ifit2 BIOCARTA_CLASSIC_PATHWAY%MSIGDB_C2%BIOCARTA_CLASSIC_PATHWAY BIOCARTA_CLASSIC_PATHWAY C2 C1s2 C7 C1qc C6 C3 C8a C9 C1rb Hc C1qa C1qb BIOCARTA_MCALPAIN_PATHWAY%MSIGDB_C2%BIOCARTA_MCALPAIN_PATHWAY BIOCARTA_MCALPAIN_PATHWAY Tln1 Prkar2a Ezr Capns1 Prkar2b Cxcr3 Acta1 Capn1 Myl2 Capns2 Mylk Prkar1b Prkar1a Egfr Hras Egf Ptk2 Prkacb Mapk1 Mapk3 Pxn Itgb1 Capn2 Itga1 BIOCARTA_PYK2_PATHWAY%MSIGDB_C2%BIOCARTA_PYK2_PATHWAY BIOCARTA_PYK2_PATHWAY Sos1 Pak1 Prkca Map2k1 Shc1 Map2k2 Mapk14 Hras Src Plcg1 Bcar1 Crkl Gnaq Map2k3 Map2k4 Mapk8 Grb2 Jun Map3k1 Prkcb Ptk2b Mapk1 Mapk3 Raf1 Rac1 PID_FAS_PATHWAY%MSIGDB_C2%PID_FAS_PATHWAY PID_FAS_PATHWAY Ikbkb Birc2 Birc3 Fas Mapk14 Fasl Pdpk1 Src Map2k6 Cltc Pik3ca Faim2 Rfc1 Syk Mapk10 Map2k7 Mapk11 Ezr Btk Mapk9 Akt1 Pik3r3 Pik3r1 Mapk8 Pik3r2 Bid Pik3cb Casp3 Pik3cd Cflar Fadd Map3k1 Ripk1 Ikbkg Casp8 Smpd1 Chuk HALLMARK_HEDGEHOG_SIGNALING%MSIGDB_C2%HALLMARK_HEDGEHOG_SIGNALING HALLMARK_HEDGEHOG_SIGNALING Dpysl2 Scg2 Nrp1 Vldlr Nrp2 Celsr1 Adgrg1 Rtn1 Amot Slit1 Gli1 Crmp1 Ets2 Shh Ptch1 Cdk6 Rasa1 Pml Ache L1cam Ldb1 Plg Tle3 Tle1 Cdk5r1 Myh9 Ophn1 Cntfr Unc5c Vegfa Nf1 Nkx6-1 Hey1 Thy1 Nrcam Hey2 PID_THROMBIN_PAR1_PATHWAY%MSIGDB_C2%PID_THROMBIN_PAR1_PATHWAY PID_THROMBIN_PAR1_PATHWAY Vasp Rock1 Plcb3 Gnai2 Adrbk2 Arrb1 Dnm2 Prkca Gnb1 Prkcd Pik3ca F2rl2 Rock2 F2 Nos3 F2r Gnaq Pik3r1 Myl2 Dnm1 Trpc6 Gna11 Akap13 Pkn1 Gnai3 Rhoa Snx2 Arhgdia Prkcg Gnao1 Snx1 Zyx Gnaz Arhgef1 Prkcb Gna13 Gna12 Gna14 Gnai1 Gng2 Plcb1 Gna15 Plcb2 BIOCARTA_EIF4_PATHWAY%MSIGDB_C2%BIOCARTA_EIF4_PATHWAY BIOCARTA_EIF4_PATHWAY Akt1 Pdk2 Eif4a1 Eif4g2 Eif4g1 Pabpc1 Pik3r1 Eif4e Ghr Prkca Eif4a2 Mknk1 Mapk14 Pten Eif4g3 Pdpk1 Prkcb Mtor Pik3ca Irs1 Eif4ebp1 Mapk1 Mapk3 BIOCARTA_FREE_PATHWAY%MSIGDB_C2%BIOCARTA_FREE_PATHWAY BIOCARTA_FREE_PATHWAY Xdh Nox1 Rela Gss Nfkb1 Gsr Gpx1 Tnf BIOCARTA_CK1_PATHWAY%MSIGDB_C2%BIOCARTA_CK1_PATHWAY BIOCARTA_CK1_PATHWAY Drd1 Prkar2a Prkar2b Cdk5 Cdk5r1 Ppp3ca Prkar1b Prkar1a Ppp2ca Drd2 Ppp1ca Prkacb Ppp1r1b Grm1 Plcb1 Csnk1d HALLMARK_NOTCH_SIGNALING%MSIGDB_C2%HALLMARK_NOTCH_SIGNALING HALLMARK_NOTCH_SIGNALING Heyl Fzd7 Arrb1 Hes1 Fzd1 Notch2 Maml2 St3gal6 Dtx4 Rbx1 Prkca Dtx1 Tcf7l2 Notch3 Fzd5 Dtx2 Jag1 Sap30 Notch1 Ppard Ccnd1 Psen2 Dll1 Kat2a Lfng Skp1a Cul1 Fbxw11 Wnt2 Wnt5a PID_ERB_GENOMIC_PATHWAY%MSIGDB_C2%PID_ERB_GENOMIC_PATHWAY PID_ERB_GENOMIC_PATHWAY Smarca4 Nr0b2 Nedd8 Ube2m Ddx54 Zfp709 Ncoa2 Ncoa3 C3 Ncoa1 Uba3 Nr0b1 Esr2 Smarce1 Smarcb1 PID_HDAC_CLASSI_PATHWAY%MSIGDB_C2%PID_HDAC_CLASSI_PATHWAY PID_HDAC_CLASSI_PATHWAY Sspo Hdac2 Ncor1 Wdr77 Hdac4 Sap30 Hdac9 Ncor2 Prkaca Tnf Prmt5 Mbd2 Tnfrsf1a Mta2 Hdac6 Hdac7 Gatad2b Gatad2a Rbbp7 Mbd3 Hdac8 Smurf1 Tfcp2 Hdac3 Stat3 Nr2c1 Mxd1 Gata2 Sin3b Fkbp3 Ranbp2 Nfkbia Hdac11 Hdac10 Gm10094 Rela Smad7 Nfkb1 Chd3 Sirt6 Smg5 Ran Sirt3 Sirt4 Sirt5 Chd4 Sirt7 Kat2b Crebbp Hdac5 Ep300 Sin3a Sirt1 Ube2i Gata1 Hdac1 Zfpm1 Pparg Xpo1 Sirt2 Yy1 Max Rbbp4 PID_HES_HEY_PATHWAY%MSIGDB_C2%PID_HES_HEY_PATHWAY PID_HES_HEY_PATHWAY Cd4 Crebbp Hes1 Neurog3 Ncor1 Runx2 Maml2 Myod1 Ep300 Ghr Camk2d Ptf1a Twist1 Ctbp1 Gata1 Rcan1 Notch1 Kdm1a Rb1 Myb Ascl1 Ncor2 Maml1 Rbpj Spen Id1 Gata6 Gata4 Jak2 Arnt Tcf3 Hes6 Hdac1 Hif1a Tle1 Ar Parp1 Ncoa1 Stat3 Gaa E2f1 Kdr Rbbp8 Cdkn1b Yy1 Hey1 Hey2 ST_GA12_PATHWAY%MSIGDB_C2%ST_GA12_PATHWAY ST_GA12_PATHWAY Cfb Dlg4 F2 Mapk7 Btk Rasal1 Mapk8 Vav1 Myef2 Nr4a3 F2rl1 F2rl3 Map2k5 Jun Src Ephb2 Ptk2 Pld3 Pld2 Mapk1 F2rl2 Pld1 Raf1 BIOCARTA_RANMS_PATHWAY%MSIGDB_C2%BIOCARTA_RANMS_PATHWAY BIOCARTA_RANMS_PATHWAY Tpx2 Rcc1 Ranbp1 Aurka Ran Kif15 Kpnb1 Numa1 BIOCARTA_RNA_PATHWAY%MSIGDB_C2%BIOCARTA_RNA_PATHWAY BIOCARTA_RNA_PATHWAY Map3k14 Nfkbia Rela Eif2ak2 Trp53 Nfkb1 Eif2s1 Dnajc3 Chuk Eif2s2 PID_CXCR3_PATHWAY%MSIGDB_C2%PID_CXCR3_PATHWAY PID_CXCR3_PATHWAY Itgal Gnai2 Cxcl11 Arrb1 Cxcl10 Cxcl13 Mlst8 Ccl11 Gnb1 Map2k1 Mapk14 Map2k2 Pdpk1 Hras Src Mtor Cxcl9 Map2k6 Pik3ca Pf4 Itgb2 Rictor Mapk11 Akt1 Cxcr3 Pik3r3 Map2k3 Pik3r1 Dnm1 Pik3r2 Kras Pik3cb Gnai3 Pik3cd Gnao1 Gnaz Mapkap1 Nras Mapk1 Gnai1 Mapk3 Gng2 Raf1 PID_RB_1PATHWAY%MSIGDB_C2%PID_RB_1PATHWAY PID_RB_1PATHWAY Smarca4 Csf2 Runx2 Skp2 Tfdp1 Mapk14 Cebpb Ctbp1 Mapk11 Elf1 Ckm Tgfb2 Hdac3 Cdkn1b Smarcb1 Raf1 Ccna2 Ccnd3 Crebbp Cbx4 Cdkn2a Myod1 Pax3 Ep300 Sirt1 Met Cdk6 Spi1 Rb1 Ccnd1 Cdk2 Ccnd2 E2f4 Cebpa Mdm2 Mitf E2f3 Hdac1 Mapk9 Suv39h1 Ccne1 Cdk4 E2f2 Pparg E2f1 Atf2 Cdkn1a Jun Tbp Gsc Taf1 Ppp2ca Aatf Brd2 Ubtf Rbp2 Atf7 Sftpd Dnmt1 Mef2c Abl1 Rbbp4 BIOCARTA_DREAM_PATHWAY%MSIGDB_C2%BIOCARTA_DREAM_PATHWAY BIOCARTA_DREAM_PATHWAY Prkar1b Jun Prkar1a Prkar2a Prkar2b Creb1 Oprk1 Prkacb Kcnip3 Mapk3 Fos Polr2a PID_TELOMERASE_PATHWAY%MSIGDB_C2%PID_TELOMERASE_PATHWAY PID_TELOMERASE_PATHWAY Wrn Hdac2 Il2 Tert Mtor Sap30 Egf Fos Hus1 Tinf2 Znfx1 Pif1 Pot1a Acd Akt1 Rbbp7 Hnrnpc Parp2 Smad3 Tnks Ywhae Terf1 Mxd1 Sin3b Nbn Hsp90aa1 Gm10094 Tgfb1 Cdkn1b Nfkb1 Mapk1 Smg5 Mapk3 Mre11a Atm Sin3a Ifng Wt1 Rad50 Nr2f2 Rad1 Pinx1 Blm Smg6 Ifnar2 Terf2ip Terf2 Sp3 Rad9a Ccnd1 Myc Irf1 Hdac1 E2f1 Jun Dkc1 Xrcc5 Egfr Sp1 Xrcc6 Esr1 Max Ube3a Abl1 Rbbp4 PID_ERBB1_RECEPTOR_PROXIMAL_PATHWAY%MSIGDB_C2%PID_ERBB1_RECEPTOR_PROXIMAL_PATHWAY PID_ERBB1_RECEPTOR_PROXIMAL_PATHWAY Sos1 Pak1 Shc1 Rasa1 Src Hras Pip5k1c Egf Ptpn1 Plcg1 Pik3ca Tln1 Gab1 Wasl Gsn Nck2 Pik3r3 Ptpn6 Pik3r1 Nck1 Pik3r2 Stat1 Kras Pik3cb Stat3 Gnai3 Ptpn11 Grb2 Pik3cd Egfr Ptk2 Nras Gnai1 Mapk1 Mapk3 BIOCARTA_G1_PATHWAY%MSIGDB_C2%BIOCARTA_G1_PATHWAY BIOCARTA_G1_PATHWAY Gsk3b Cdc25a Cdkn2a Atm Skp2 Tfdp1 Cdk6 Smad4 Rb1 Trp53 Ccnd1 Dhfr Cdk2 Cdk1 Tgfb2 Hdac1 Cdkn2b Ccne1 Cdk4 Smad3 E2f1 Cdkn1a Ccna1 Tgfb1 Cdkn1b Tgfb3 Abl1 PID_ALK2_PATHWAY%MSIGDB_C2%PID_ALK2_PATHWAY PID_ALK2_PATHWAY Smad4 Smad1 Smad9 Amhr2 Bmpr2 Tlx2 Amh Acvr1 Fkbp1a Bmp7 Smad5 PID_INTEGRIN2_PATHWAY%MSIGDB_C2%PID_INTEGRIN2_PATHWAY PID_INTEGRIN2_PATHWAY Icam1 Itgal Icam4 Gp1ba Cd40lg Vcam1 Itgax Jam3 F11r Proc Plaur Itgad Plat Fga Icam2 Itgam Fgb Fcgr3 Fgg Itgb2 Cyr61 Spon2 F10 C3 Plau Thy1 Kng2 Tgfbi SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES%MSIGDB_C2%SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Pak6 Sos1 Pak7 Pak3 Pak4 Erbb4 Gsk3b Pard3 Ppp1r13b Creb1 Ywhaz Prex1 Gsk3a Tsc2 Igfbp1 Slc2a4 Tsc1 Cyth3 Rps6ka1 Shc1 Bcl2l1 Mtor Ptpn1 Sfn Nolc1 Akt3 Irs4 Akt1 Pdk1 Ywhae Foxo3 Akt2 Pten Ywhab Cdkn1b Irs1 Creb3 Ywhah Pik3r5 Inppl1 Ywhag Sos2 Igf1 Cdkn2a Pak1 Met Ebp Pik3ca Cdk2 F2rl2 Bad Myc Irs2 Gab1 Pard6a Gadd45a Rps6ka3 Pak2 Grb2 Pik3cd Rps6ka2 Ptk2 Ifi27 PID_NFKAPPAB_ATYPICAL_PATHWAY%MSIGDB_C2%PID_NFKAPPAB_ATYPICAL_PATHWAY PID_NFKAPPAB_ATYPICAL_PATHWAY Csnk2b Sspo Ikbkb Arrb2 Pik3r1 Lck Bcl3 Mapk14 Nfkbia Src Rela Nfkb1 Pik3ca Syk Csnk2a2 Rel BIOCARTA_EPONFKB_PATHWAY%MSIGDB_C2%BIOCARTA_EPONFKB_PATHWAY BIOCARTA_EPONFKB_PATHWAY Cdkn1a Epo Nfkbia Hif1a Grin1 Sod2 Rela Nfkb1 Epor Jak2 Arnt BIOCARTA_NTHI_PATHWAY%MSIGDB_C2%BIOCARTA_NTHI_PATHWAY BIOCARTA_NTHI_PATHWAY Il1b Mapk11 Ikbkb Crebbp Dusp1 Map2k3 Ep300 Smad3 Tlr2 Myd88 Smad4 Mapk14 Map3k14 Nfkbia Rela Map2k6 Nfkb1 Chuk Map3k7 Nr3c1 Tgfbr2 Tnf Tgfbr1 BIOCARTA_CARDIACEGF_PATHWAY%MSIGDB_C2%BIOCARTA_CARDIACEGF_PATHWAY BIOCARTA_CARDIACEGF_PATHWAY Ednra Ednrb Prkca Rhoa Jun Adam12 Agt Egfr Prkcb Hras Agtr1a Egf Rela Nfkb1 Plcg1 Edn1 Fos Myc ST_ERK1_ERK2_MAPK_PATHWAY%MSIGDB_C2%ST_ERK1_ERK2_MAPK_PATHWAY ST_ERK1_ERK2_MAPK_PATHWAY Sos1 Klf6 Eef2k Creb1 Mknk2 Araf Mknk1 Rps6ka1 Shc1 Map2k1 Map2k2 Braf Bad Kat5 Rps6ka3 Dusp9 Eif4e Rap1a Dusp4 Dusp6 Grb2 Mos Traf3 Map3k8 Rps6ka2 Nfkb1 Mapk1 Mapk3 Creb3 Sos2 ST_TUMOR_NECROSIS_FACTOR_PATHWAY%MSIGDB_C2%ST_TUMOR_NECROSIS_FACTOR_PATHWAY ST_TUMOR_NECROSIS_FACTOR_PATHWAY Nfkbil1 Birc2 Birc3 Tnfaip3 Map3k3 Tnf Tnfrsf1a Bag4 Tonsl Tnfrsf1b Nfkb2 Map2k4 Casp3 Traf2 Jun Cflar Nfkbib Nfkbie Fadd Nfkbia Tradd Agfg1 Ikbkg Ripk1 Casp8 Ralbp1 Nr2c2 Nfkb1 Map3k7 BIOCARTA_PAR1_PATHWAY%MSIGDB_C2%BIOCARTA_PAR1_PATHWAY BIOCARTA_PAR1_PATHWAY Arhgef18 Rock1 Adcy1 Prkca Gnb1 Pik3ca F2 F2r Gnaq Pik3r1 Arhgef9 Ppp1r12b F2rl3 Rhoa Arhgef4 Pik3cg Arhgef3 Arhgef2 Arhgef1 Prkcb Arhgef6 Gngt1 Ptk2b Gna13 Gna12 Arhgef10 Arhgef11 Gnai1 Arhgef12 Arhgef7 Arhgef19 Plcb1 Map3k7 Arhgef15 Arhgef16 Arhgef17 ST_B_CELL_ANTIGEN_RECEPTOR%MSIGDB_C2%ST_B_CELL_ANTIGEN_RECEPTOR ST_B_CELL_ANTIGEN_RECEPTOR Sos1 Ppp1r13b Nfkbil1 Prdx1 Shc1 Map2k1 Map2k2 Ephb2 Pik3ca Bad Syk Akt3 Tonsl Btk Akt1 Plcg2 Nfkb2 Pik3r1 Vav1 Akt2 Grb2 Pik3cd Cd19 Nfkbib Nfkbie Csk Nfkbia Dag1 Lyn Nfkb1 Mapk1 Itpkb Blnk Bcr Sos2 Itpka Raf1 Nfat5 PID_SMAD2_3PATHWAY%MSIGDB_C2%PID_SMAD2_3PATHWAY PID_SMAD2_3PATHWAY Ppm1a Tgfbrap1 Smad3 Smad4 Ube2i Nup214 Map3k1 Smad2 Ctdspl Ctdsp1 Pias4 Mapk1 Mapk3 Nup153 Kpnb1 BIOCARTA_BLYMPHOCYTE_PATHWAY%MSIGDB_C2%BIOCARTA_BLYMPHOCYTE_PATHWAY BIOCARTA_BLYMPHOCYTE_PATHWAY Icam1 Cd40 Itgal Cr2 Ptprc Cd80 H2-Eb1 Fcgr2b Itgb2 SA_MMP_CYTOKINE_CONNECTION%MSIGDB_C2%SA_MMP_CYTOKINE_CONNECTION SA_MMP_CYTOKINE_CONNECTION Il1b Tnfrsf1a Sell Tnfrsf1b Tnfrsf8 Tgfb2 Cd44 Csf1 Spn Fcgr4 Ace Il6ra Tgfb1 Tnfsf8 Tnf ST_GRANULE_CELL_SURVIVAL_PATHWAY%MSIGDB_C2%ST_GRANULE_CELL_SURVIVAL_PATHWAY ST_GRANULE_CELL_SURVIVAL_PATHWAY Apc Cxcl1 Cxcr2 Creb1 Cerk Ephb2 Fos Mapk10 Map2k7 Mapk9 Gnaq Map2k4 Mapk8 Parp1 Casp3 Jun Asah1 Dag1 Mapk8ip3 Mapk8ip2 Mapk1 Mapk8ip1 Itpkb Creb3 Itpka Camp BIOCARTA_STEM_PATHWAY%MSIGDB_C2%BIOCARTA_STEM_PATHWAY BIOCARTA_STEM_PATHWAY Csf2 Cd4 Il6 Epo Il7 Csf3 Il9 Csf1 Il11 Il5 Il4 Il2 Cd8a PID_TRKR_PATHWAY%MSIGDB_C2%PID_TRKR_PATHWAY PID_TRKR_PATHWAY Sos1 Shc1 Map2k1 Rit1 Rit2 Hras Gab2 Ehd4 Bdnf Shc2 Dnaja3 Tiam1 Crk Ntf3 Nedd4l Ntrk3 Rapgef1 Rasgrf1 Rap1b Frs3 Frs2 Arhgap32 Rap1a Gipc1 Shc3 Stat3 Ptpn11 Rhog Rhoa Rgs19 Faim Mcf2l Ntrk2 Maged1 Nras Mapk1 Mapk3 Rac1 Elmo1 Ngfr Rasa1 Sqstm1 Plcg1 Matk Pik3ca Ccnd1 Prkcz Gab1 Crkl Ntf5 Pik3r1 Dnm1 Prkci Kras Grb2 Sh2b1 Ntrk1 Dock1 Abl1 Ngf PID_AVB3_OPN_PATHWAY%MSIGDB_C2%PID_AVB3_OPN_PATHWAY PID_AVB3_OPN_PATHWAY Cd44 Itgb3 Mmp2 Pik3ca Rock2 Fos Bcar1 Syk Ilk Gsn Pik3r1 Mapk8 Rhoa Vav3 Jun Plau Map3k14 Map3k1 Nfkbia Mmp9 Ptk2b Rela Nfkb1 Mapk1 Itgav Mapk3 Chuk Spp1 Pip5k1a Rac1 SIG_BCR_SIGNALING_PATHWAY%MSIGDB_C2%SIG_BCR_SIGNALING_PATHWAY SIG_BCR_SIGNALING_PATHWAY Sos1 Gsk3b Ppp1r13b Cr2 Gsk3a Shc1 Flot1 Nfatc1 Nfatc2 Pik3ca Flot2 Bad Cd22 Syk Cd81 Map4k1 Akt3 Nr0b2 Btk Akt1 Plcg2 Pdk1 Bcl2 Pik3r1 Ptprc Vav1 Ppp3cc Inpp5d Ppp3ca Akt2 Grb2 Ppp3cb Pik3cd Cd19 Itpr3 Csk Dag1 Lyn Mapk1 Mapk3 Blnk Itpr1 Bcr Sos2 Raf1 Itpr2 BIOCARTA_IL10_PATHWAY%MSIGDB_C2%BIOCARTA_IL10_PATHWAY BIOCARTA_IL10_PATHWAY Il6 Jak1 Il1a Stat2 Blvrb Stat6 Il10 Stat1 Stat3 Il10ra Blvra Stat5b Stat5a Stat4 Il10rb Hmox1 Tnf BIOCARTA_INTEGRIN_PATHWAY%MSIGDB_C2%BIOCARTA_INTEGRIN_PATHWAY BIOCARTA_INTEGRIN_PATHWAY Sos1 Rock1 Acta1 Tns1 Shc1 Map2k1 Map2k2 Hras Src Pxn Actn1 Itgb1 Bcar1 Actn2 Tln1 Crkl Actn3 Capns1 Capn1 Rapgef1 Mapk8 Capns2 Rap1a Ppp1r12b Fyn Grb2 Rhoa Jun Vcl Zyx Csk Cav1 Ptk2 Mapk1 Mapk3 Raf1 Bcr Itga1 BIOCARTA_PLATELETAPP_PATHWAY%MSIGDB_C2%BIOCARTA_PLATELETAPP_PATHWAY BIOCARTA_PLATELETAPP_PATHWAY Plg F2 Col4a5 App Col4a6 Plau Col4a4 Col4a2 Col4a3 F9 Col4a1 Plat F11 Serpine1 PID_HIV_NEF_PATHWAY%MSIGDB_C2%PID_HIV_NEF_PATHWAY PID_HIV_NEF_PATHWAY Apaf1 Dffa Dffb Birc3 Casp7 Fas Cd247 Traf1 Fasl Cradd Daxx Map3k5 Casp2 Tnf Tnfrsf1a Map2k7 Bag4 Bcl2 Mapk8 Bid Casp6 Casp3 Casp9 Traf2 Cflar Map3k14 Fadd Nfkbia Tradd Ripk1 Casp8 Rela Nfkb1 Chuk PID_S1P_S1P3_PATHWAY%MSIGDB_C2%PID_S1P_S1P3_PATHWAY PID_S1P_S1P3_PATHWAY Gnai2 Pdgfrb Src Itgb3 Jak2 Cxcr4 Akt3 Gnaq Akt1 S1pr2 S1pr1 S1pr3 Gna11 Gnai3 Rhoa Gnao1 Gnaz Pdgfb Gna13 Gna12 Gna14 Gnai1 Vegfa Mapk1 Itgav Mapk3 Flt1 Gna15 Rac1 PID_CERAMIDE_PATHWAY%MSIGDB_C2%PID_CERAMIDE_PATHWAY PID_CERAMIDE_PATHWAY Igf1 Ksr1 Pdgfa Smpd3 Sphk2 Map4k4 Birc3 Nsmaf Map2k1 Aifm1 Map2k2 Cradd Madd Prkra Ctsd Prkcd Egf Rb1 Eif2ak2 Bad Myc Prkcz Tnf Eif2a Tnfrsf1a Bag4 Akt1 Map2k4 Bcl2 Bax Mapk8 Bid Traf2 Fadd Map3k1 Nfkbia Tradd Ripk1 Asah1 Casp8 Rela Smpd1 Pawr Nfkb1 Mapk1 Mapk3 Raf1 HALLMARK_MYC_TARGETS_V1%MSIGDB_C2%HALLMARK_MYC_TARGETS_V1 HALLMARK_MYC_TARGETS_V1 Vdac1 Ldha Mcm7 Eif3j2 Rps3 Nap1l1 Hsp90ab1 Fbl Ddx18 Eif4a1 Prps2 Cad Cdc45 Got2 Rpl22 Phb Srpk1 Eef1b2 Ssbp1 Ncbp2 Pcna Phb2 Ncbp1 Tfdp1 Nhp2 Pold2 Rsl1d1 Hnrnpa2b1 Snrpa Nop56 Txnl4a Hnrnpr Cct3 Vdac3 Cct2 Gspt1 Eif4e Ywhae Eif3d Rfc4 Ran Ccna2 Hprt Srsf2 Hdgf Odc1 Prdx4 Eif2s2 Mcm4 Ranbp1 Cdk2 Apex1 Myc Trim28 Smarcc1 Rrm1 Snrpd1 Eif2s1 Abce1 Xpo1 Tra2b Tyms Slc25a3 Kpnb1 Cops5 Srsf1 Srm Tardbp Snrpa1 Sf3a1 Hdac2 Glo1 Canx Eif3b Psmd7 Ssb Mad2l1 Psmd3 Syncrip Prpf31 Rps5 Lsm2 Cct4 C1qbp Psmd8 Hnrnpu Acp1 Cdc20 Nolc1 Psmc6 Serbp1 Psmc4 Cnbp Xpot H2afz Nme1 Hnrnpc Ifrd1 Cul1 Bub3 Dut Ctps Rpl34 Pwp1 Cyc1 Ppia Psmd14 Srsf7 Tomm70a Srsf3 Pabpc1 Ilf2 Iars Ap3s1 Exosc7 Cct5 Tcp1 Tufm Cct7 Rps10 Pgk1 Rnps1 Dhx15 Pabpc4 Gnb2l1 Psmb2 Ube2l3 Psmb3 Snrpb2 Usp1 Pcbp1 Pole3 Hspd1 Ndufab1 Psma7 Ube2e1 Rrp9 Clns1a Eif4h Dek Nop16 Hnrnpa1 Vbp1 Ddx21 Snrpd2 Eif4g2 Rpl18 Etf1 Kars Ppm1g Eprs Orc2 Cdk4 Stard7 Mcm2 Gnl3 Ruvbl2 Mrps18b Rad23b Aimp2 Hnrnpd Prdx3 Fam120a Cstf2 Npm1 Mrpl9 Uba2 Sf3b3 Hnrnpa3 Hddc2 Mcm5 Psmd1 Xrcc6 Mcm6 Lsm7 Psma1 Psma2 Eif1ax Cbx3 Psma6 Cox5a Pa2g4 Psma4 G3bp1 Snrpd3 BIOCARTA_NGF_PATHWAY%MSIGDB_C2%BIOCARTA_NGF_PATHWAY BIOCARTA_NGF_PATHWAY Sos1 Pik3r1 Mapk8 Grb2 Ngfr Map2k1 Shc1 Jun Pik3cg Elk1 Hras Plcg1 Pik3ca Mapk3 Fos Raf1 Ngf BIOCARTA_CD40_PATHWAY%MSIGDB_C2%BIOCARTA_CD40_PATHWAY BIOCARTA_CD40_PATHWAY Cd40 Ikbkb Dusp1 Ikbkap Cd40lg Tnfaip3 Traf3 Map3k14 Traf6 Nfkbia Map3k1 Ikbkg Rela Nfkb1 Chuk HALLMARK_COAGULATION%MSIGDB_C2%HALLMARK_COAGULATION HALLMARK_COAGULATION Klf7 Mmp1a Fbn1 F9 Thbd C8a C9 Sh2b2 C1rb C1qa Klk8 Itga2 Rac1 Ctse S100a1 Serpinb2 Ctsb Hmgcs2 Gp1ba Lta4h Dct Hrg Itgb3 Lamp2 Pf4 Fga Acox2 A2m Fgg Tmprss6 Crip2 Gnb2 Prep Mep1a C1s2 Gda Mst1 Prss23 Iscu Olr1 Capn5 S100a13 F12 Cpq F8 Rgn Serping1 Casp9 Wdr1 Pef1 Gng12 Thbs1 Mmp3 C2 Plau Ctsh Ctsl Ctsk C8g Mmp9 Ctso Lrp1 C8b Cpb2 Adam9 Mmp10 Mmp15 F13b Mmp11 Serpine1 Mmp14 Klkb1 Timp3 P2ry1 Proz Serpina1d Pecam1 Serpina1a Rapgef3 Usp11 Trf Plek Cfh Tfpi2 Arf4 Bmp1 Hnf4a Ang Hpn Dusp14 Mmp8 Apoc2 Apoc1 Rabif Cpn1 Msrb2 Apoc3 Cfi Furin Proc Gp9 Mmp2 Masp2 Plat Vwf Htra1 Anxa1 Dpp4 Csrp1 Mmp7 Plg Cfb F2 Pros1 Itih1 Fn1 Apoa1 Mbl2 Lefty2 Sparc Cd9 F3 Comp Cfd F2rl2 Capn2 F11 Clu F10 Gsn Serpinc1 C3 Dusp6 Fyn Timp1 Lgmn Pdgfb Sirt2 Maff SIG_CHEMOTAXIS%MSIGDB_C2%SIG_CHEMOTAXIS SIG_CHEMOTAXIS Pak6 Rock1 Pak7 Pak3 Pak4 Ppp1r13b Pak1 Wasf1 Racgap1 Pik3ca Rock2 Akt3 Wasl Btk Akt1 Pdk1 Pik3r1 Gdi2 Cfl2 Pak2 Angptl2 Limk1 Mylk Rps4x Sag Mylk2 Akt2 Gdi1 Pik3cd Itpr3 Pik3cg Pten Arhgap4 Arhgap1 Pitx2 Rho Arhgef11 Actr3 Inppl1 Itpr1 Pik3r5 Actr2 Itpr2 PID_S1P_S1P4_PATHWAY%MSIGDB_C2%PID_S1P_S1P4_PATHWAY PID_S1P_S1P4_PATHWAY Gnai2 S1pr5 S1pr4 Gnai3 Rhoa Gnao1 Gnaz Gna13 Gna12 Plcg1 Mapk1 Gnai1 Mapk3 HALLMARK_ANDROGEN_RESPONSE%MSIGDB_C2%HALLMARK_ANDROGEN_RESPONSE HALLMARK_ANDROGEN_RESPONSE Slc38a2 Adamts1 Mertk Akap12 Lman1 Sms Acsl3 Bmpr1b Abcc4 Ube2j1 Stk39 Vapa Camkk2 Spcs3 Cdc14b B4galt1 Ptpn21 Rab4a Arid5b Inpp4b Srp19 Gucy1a3 Fkbp5 Map7 Herc3 Dnajb9 Slc26a2 Pgm3 Lifr Aldh1a3 Zmiz1 Sat1 Pias1 Dbi Pdlim5 Abhd2 Ank Appbp2 Sepp1 Akt1 Ndrg1 Gnai3 Dhcr24 H1f0 Sgk1 Ell2 Ccnd3 Adrm1 Spdef Gsr Scd1 Hmgcr Cdk6 Ube2i Hpgd Srf Ccnd1 Fads1 Actn1 Idi1 Nkx3-1 Tmprss2 Rps6ka3 Elovl5 Ppap2a Mak Elk4 Azgp1 Ngly1 Tmem50a Steap4 Rrp12 Xrcc5 Pmepa1 B2m Cenpn Krt8 Insig1 Tsc22d1 Ptk2b Xrcc6 Gpd1l Homer2 Zbtb10 Tnfaip8 Itgav Sec24d Uap1 Pa2g4 Iqgap2 Hsd17b14 Maf Sord ST_INTEGRIN_SIGNALING_PATHWAY%MSIGDB_C2%ST_INTEGRIN_SIGNALING_PATHWAY ST_INTEGRIN_SIGNALING_PATHWAY Sos1 Pak6 Pak7 Pak3 Pak4 Arhgap35 Shc1 Was Braf Bcar1 Cse1l Akt3 Ilk Crk Grb7 Akt1 Mapk8 Angptl2 Itga5 Pik3cb Rala Mylk2 Akt2 Arhgap26 Tln2 Pten Tnk2 Zyx Itgb3bp P4hb Itga11 Cav1 Itga10 Rho Mapk8ip3 Itga8 Mapk8ip2 Itga9 Mapk8ip1 Mapk1 Itga6 Itga7 Itga4 Actr3 Raf1 Itga2 Sos2 Actr2 Itga1 Vasp Rock1 Cdkn2a Itga3 Pak1 Src Terf2ip Ephb2 Plcg1 Pik3ca Rock2 Actn1 Mapk10 Map2k7 Tln1 Mapk9 Pklr Map3k11 Plcg2 Asap1 Map2k4 Mras Pak2 Mylk Fyn Grb2 Arhgef6 Ptk2 Dock1 Arhgef7 Abl1 BIOCARTA_MEF2D_PATHWAY%MSIGDB_C2%BIOCARTA_MEF2D_PATHWAY BIOCARTA_MEF2D_PATHWAY Cabin1 Capns1 Hdac1 Hdac2 Ep300 Capns2 Mef2d Prkca Ppp3cc Ppp3ca Ppp3cb Prkcb Nfatc1 Nfatc2 Capn2 HALLMARK_APICAL_JUNCTION%MSIGDB_C2%HALLMARK_APICAL_JUNCTION HALLMARK_APICAL_JUNCTION Actn4 B4galt1 Shc1 Slc30a3 Exoc4 Actc1 Gamt Syk Mvd Sdc3 Pfn1 Vcl Myh9 Cldn8 Tgfbi Icam4 Hadh Cd34 Arhgef6 Mmp9 Icam1 Pecam1 Col17a1 Dmp1 Mapk14 Vwf Nlgn3 Crb3 Pbx2 Mapk11 Cntn1 Pcdh1 Nf2 Dsc1 Ctnna1 Dsc3 Mapk13 Dlg1 Cdh3 Nfasc Cadm3 Cadm2 Dhx16 Rsu1 Acta2 Nlgn2 Mdk Zyx Ppp2r2c Alox8 Pard6g Myh10 Jup Vav2 Cdh15 Rras Myl12a Cdh11 Myl12b Nrxn2 Mpp5 Cdk8 Madcam1 Cercam Tnfrsf11b Pvrl2 Skap2 Negr1 Rhof Parva Cd209a Cdh4 Rasa1 Cdh6 Cdh8 Flnc Ctnnd1 Stx4a Sirpa Src Lima1 Evl Amigo1 Cdh1 Amigo2 Cnn2 Plcg1 Tspan4 Sympk Pvrl4 Shroom2 Actn1 Tial1 Pvrl1 Pvrl3 Mpzl1 Mpzl2 Wasl Atp1a3 Pkd1 Slit2 Cldn11 Cldn18 Pik3r3 Cldn19 Calb2 Wnk4 Cldn14 Amh Tjp1 Cldn15 Tubg1 Cldn7 Ldlrap1 Pdzd3 Nrap Cdsn Nrtn Krt31 Adam15 Actb Cd274 Adra1b Gtf2f1 Adam23 Layn Icam5 Cd276 Nf1 Nexn Sgce Tro Adamts5 Epb4.1l2 Tsc1 Lamc2 Hras Fbn1 Lama3 Itgb4 Col16a1 Ptprc Pten Cd86 Itga10 Itga9 Irs1 Ywhah Itga2 Vasp Gnai2 Cx3cl1 Traf1 Map4k2 Col9a1 Baiap2 Fyb Zak Egfr Thbs3 Ptk2 Lamb3 Adam9 Rac2 Thy1 Acta1 Bmp1 Vcam1 Jam3 Mmp2 Icam2 Itgb1 Speg Akt3 Grb7 Pik3cb Crat Akt2 Ikbkg Cap1 Arpc2 Inppl1 Sorbs3 Actg1 Kcnh2 Itga3 Actn2 Actn3 Msn Cldn5 Fscn1 Cldn4 Cldn9 Insig1 Cldn6 Gnai1 Vcan BIOCARTA_CCR3_PATHWAY%MSIGDB_C2%BIOCARTA_CCR3_PATHWAY BIOCARTA_CCR3_PATHWAY Ccr3 Gnaq Nox1 Myl2 Limk1 Prkca Ppp1r12b Ccl11 Rhoa Gnb1 Map2k1 Prkcb Hras Gngt1 Ptk2 Mapk1 Mapk3 Rock2 Plcb1 Pik3c2g Raf1 HALLMARK_ESTROGEN_RESPONSE_EARLY%MSIGDB_C2%HALLMARK_ESTROGEN_RESPONSE_EARLY HALLMARK_ESTROGEN_RESPONSE_EARLY Abca3 B4galt1 Wisp2 Fkbp5 Tsku Slc7a5 Cish Krt15 Gab2 Slc26a2 Tiparp Ncor2 Fhl2 Cxcl12 Fasn Rhod Fos Sfn Chpt1 Svil Abhd2 Jak2 Tubb2b Deptor Greb1 Slc1a4 Celsr2 Thsd4 Unc119 Slc19a2 Gja1 Med24 Slc1a1 Isg20l2 Mlph Cant1 Fcmr Add3 Mybl1 Syt12 Sybu Kcnk15 Rhobtb3 Tgm2 Cbfa2t3 Tmem164 Ttc39a Akap1 Sh3bp5 Ovol2 Tob1 Rasgrp1 Stc2 Gla Opn3 Elf3 Tjp3 Amfr Aldh3b1 Nbl1 Podxl Slc24a3 Cyp26b1 Slc39a6 Il6st Rab31 Slc2a1 Nadsyn1 Rapgefl1 Hr P2ry2 Hes1 Mreg Slc9a3r1 Cd44 Pdzk1 Npy1r Syngr1 Frk Lad1 Tgif2 Dynlt3 Flnb Il17rb Ppif Slc22a5 Rab17 Mybbp1a Tpbg Itpk1 Slc16a1 Arl3 Lrig1 Ugcg Myb Krt18 Gfra1 Klf10 Abat Ccnd1 Pla2g16 Foxc1 Fam134b Myc Wfs1 Olfm1 Clic3 Endod1 Tmprss3 Dlc1 Inpp5f Asb13 Slc37a1 Wwc1 Prss23 Snx24 Bcl2 Slc7a2 Blvrb Kdm4b Farp1 Tbc1d30 Myof Med13l Tfap2c Aff1 Ret Scnn1a Mill2 Tff3 Inhbb Fam102a Kazn Rbbp8 Kcnk5 Muc1 Esrp2 Elovl2 Klk10 Olfml3 Fam63a Sox3 Calcr Krt13 Msmb Bag1 Adcy1 Ablim1 Mast4 Anxa9 Bcl11b Igfbp4 Egr3 Adcy9 Sult2b1 Elf1 Tiam1 Hspb8 Pex11a Papss2 Rara Igf1r Celsr1 Dhcr7 Sec14l2 Aqp3 Siah2 Tpd52l1 Nxt1 Fkbp4 Dhrs3 Slc27a2 Scarb1 Xbp1 Ar Calb2 Nrip1 Pgr Areg Fdft1 Elovl5 Cldn7 Bhlhe40 Sema3b Rrp12 Reep1 Ptges Krt8 Klf4 Car12 Rps6ka2 PID_BETA_CATENIN_DEG_PATHWAY%MSIGDB_C2%PID_BETA_CATENIN_DEG_PATHWAY PID_BETA_CATENIN_DEG_PATHWAY Apc Axin1 Axin2 Sspo Gsk3b Skp1a Dvl1 Dvl3 Gsk3a Cul1 Fzd5 Wnt3a Ctnnb1 Csnk1a1 Dvl2 Lrp6 Csnk1e Csnk1d BIOCARTA_BIOPEPTIDES_PATHWAY%MSIGDB_C2%BIOCARTA_BIOPEPTIDES_PATHWAY BIOCARTA_BIOPEPTIDES_PATHWAY Sos1 Camk2a Stat2 Camk2b Prkca Stat6 Camk2d Camk2g Gnb1 Shc1 Map2k1 Mapk14 Map2k2 Stat5b Stat5a Hras Stat4 Plcg1 Jak2 F2 Cdk5 Mapk8 Mylk Stat1 Gna11 Stat3 Fyn Agtr2 Grb2 Agt Prkcb Gngt1 Ptk2b Gnai1 Mapk1 Mapk3 Raf1 Kng2 ST_ADRENERGIC%MSIGDB_C2%ST_ADRENERGIC ST_ADRENERGIC Apc Mapk14 Src Braf Pik3ca Mapk10 Cfb Phka2 Gnaq Akt1 Ar Pik3r1 Gna11 Ccl2 Pik3cd Itpr3 Egfr Kcnj3 Asah1 Dag1 Pitx2 Gnai1 Ptx3 Mapk1 Itpkb Gast Kcnj5 Itpr1 Camp Gna15 Itpka Raf1 Kcnj9 Itpr2 PID_VEGF_VEGFR_PATHWAY%MSIGDB_C2%PID_VEGF_VEGFR_PATHWAY PID_VEGF_VEGFR_PATHWAY Nrp1 Nrp2 Pgf Kdr Vegfb Vegfc Vegfa Flt4 Figf Flt1 PID_ATF2_PATHWAY%MSIGDB_C2%PID_ATF2_PATHWAY PID_ATF2_PATHWAY Hrk Jdp2 Cbfb Creb1 Hbb-bh1 Dusp10 Dusp8 Pdgfra Serpinb5 Prkca Dusp5 H2afy Bcl2l1 Mapk14 Junb Csrp2 Pou2f1 Atf3 Mmp2 Jund Ache Fos Mapk11 Tgfb2 Dusp1 Mapk8 Cul3 Ppargc1a Mapk1 Mapk3 Ccna2 Col24a1 Il6 Hes1 Sele Ep300 Ifng Th Arg1 Rb1 Ccnd1 Ins2 Il23a Gadd45a Mapk9 Kat5 Bcl2 Cdk4 Ruvbl2 Socs3 Ddit3 Atf2 Jun Plau Esr1 Brca1 Nf1 Nos2 PID_P38_ALPHA_BETA_PATHWAY%MSIGDB_C2%PID_P38_ALPHA_BETA_PATHWAY PID_P38_ALPHA_BETA_PATHWAY Pak3 Dusp10 Dusp8 Pak1 Mapk14 Map3k3 Yes1 Src Map2k6 Blk Ccm2 Mapk11 Dusp16 Dusp1 Map2k3 Map2k4 Ralb Pak2 Hck Lck Fyn Rala Traf6 Ripk1 Map3k12 Fgr Tab1 Lyn Rac1 Prkg1 ST_G_ALPHA_S_PATHWAY%MSIGDB_C2%ST_G_ALPHA_S_PATHWAY ST_G_ALPHA_S_PATHWAY Cfb Snx13 Rapgef3 Creb1 Src Terf2ip Asah1 Braf Mapk1 Gast Creb3 Camp Raf1 BIOCARTA_NKCELLS_PATHWAY%MSIGDB_C2%BIOCARTA_NKCELLS_PATHWAY BIOCARTA_NKCELLS_PATHWAY Klrc1 Ptpn6 Pik3r1 Lat Pak1 Vav1 Map2k1 B2m Klrd1 Ptk2b H2-Q10 Pik3ca Mapk3 Itgb1 Il18 Syk Rac1 NABA_ECM_REGULATORS%MSIGDB_C2%NABA_ECM_REGULATORS NABA_ECM_REGULATORS Adam18 Adam19 Adamts1 Ky Ambp Adam11 Adam10 Cst11 Adamts20 Cst10 Serpind1 Itih5 Cela3b Itih2 Cpn2 Serpinb7 Serpinb9 Prss12 Adam29 Adamts14 Adam28 Adamts15 Tll2 Adamts16 F9 Adamts18 Adamts19 Pamr1 Slpi Hpse2 Adam21 Adam22 Adamts10 Adamts12 P4ha3 Adam8 Serpina10 Adam7 Serpini2 Ogfod2 Tmprss15 Serpinh1 Adam2 Lox Habp2 Serpinf2 Serpina3n Ogfod1 F7 Loxl4 Tgm2 Loxl3 Serpinf1 Timp4 Adamtsl1 Tgm1 Serpinb8 Prss2 Adamtsl3 Adamtsl4 Adamtsl2 Timp2 Serpina7 Serpina5 Adamtsl5 Serpina9 Serpinb6a Serpini1 Cela2a Cd109 Ctse Serpinb2 Ctsb Elane P4htm Itih3 Loxl1 Loxl2 Serpine3 Serpine2 A2m Plau Mmp3 P4ha2 Ctsg Mmp9 Serpine1 Mmp13 Mmp12 Kng2 Serpinc1 Adam15 Adam23 P4ha1 Adamts5 Serpinb5 Ctsd Mmp1a Adam17 Egln2 Hrg Ctss Mep1a F12 Serping1 Agt Ctsh Ctsl Ctsk Ctso Adam9 Mmp10 Mmp15 F13b Mmp11 Mmp14 Timp3 Serpina1d Serpina1a Bmp1 Hyal3 Mmp8 Hyal1 Pappa Kazald1 Htra4 Serpinb3a Serpinb3d Hyal2 Tgm4 Tgm5 Mmp2 Htra3 Plat Masp2 Tgm6 Htra1 Adamdec1 Tgm3 Mmp7 Plg Itih4 F2 Itih1 Serpina6 Mmp23 Plod2 Mmp25 Mmp24 P3h3 Fam20c Cstl1 Fam20b Adamts7 Mmp17 Adamts8 Adamts6 F13a1 Mmp16 Plod1 Plod3 Mmp21 Adam12 Sulf1 Mmp20 Adam30 Adam32 Adam33 Tll1 Adamts13 Mmp27 P3h2 Fam20a Mmp28 P3h1 2010005H15Rik Mep1b Sulf2 Serpinb10 Serpina12 Serpina11 F10 Pcsk6 Serpinb13 Serpinb12 Serpinb11 Egln3 Cst7 Cst6 Hyal5 Hyal4 Pcsk5 Cst9 Ngly1 Cst8 Ctsa Timp1 Cela1 Adamts3 Ctsf Ctsc Adamts4 Hpse Adamts2 Mmp19 St14 Ctsz Cst3 Pappa2 Astl Cstb Ctsw Serpinb1a PID_IFNG_PATHWAY%MSIGDB_C2%PID_IFNG_PATHWAY PID_IFNG_PATHWAY Il1b Jak1 Crebbp Camk2a Irf9 Dapk1 Ptges2 Ep300 Camk2b Camk2d Casp1 Camk2g Ifng Map2k1 Cebpb Mtor Prkcd Pias4 Ifngr1 Pik3ca Pias1 Jak2 Irf1 Crkl Ptpn2 Map3k11 Akt1 Pik3r1 Rapgef1 Rap1b Stat1 Rap1a Stat3 Ptpn11 Map3k1 Smad7 Mapk1 Socs1 Mapk3 Cbl BIOCARTA_D4GDI_PATHWAY%MSIGDB_C2%BIOCARTA_D4GDI_PATHWAY BIOCARTA_D4GDI_PATHWAY Jun Prf1 Gzmb Casp8 Apaf1 Arhgdib Parp1 Casp3 Arhgap5 Casp1 Casp9 PID_EPHB_FWD_PATHWAY%MSIGDB_C2%PID_EPHB_FWD_PATHWAY PID_EPHB_FWD_PATHWAY Efnb1 Rock1 Rras Efnb2 Efna5 Trf Kalrn Efnb3 Pak1 Ephb3 Map4k4 Itsn1 Synj1 Gria1 Shc1 Map2k1 Rasa1 Src Hras Ephb2 Ephb1 Ephb4 Pik3ca Pxn Wasl Grb7 Crk Pik3r1 Nck1 Rap1b Dnm1 Rap1a Kras Grb2 Ptk2 Nras Mapk1 Mapk3 Rac1 PID_IL2_PI3K_PATHWAY%MSIGDB_C2%PID_IL2_PI3K_PATHWAY PID_IL2_PI3K_PATHWAY Sos1 Il2rg Jak1 Jak3 Sgms1 Shc1 Bcl2l1 Il2ra Il2 Tert Mtor Ugcg Gab2 Myb Pik3ca Prkcz Myc Akt1 Bcl2 Pik3r1 Lck Foxo3 Ptpn11 Grb2 E2f1 Hsp90aa1 Smpd1 Rela Nfkb1 Il2rb Eif3a Rac1 PID_INSULIN_GLUCOSE_PATHWAY%MSIGDB_C2%PID_INSULIN_GLUCOSE_PATHWAY PID_INSULIN_GLUCOSE_PATHWAY Gsk3b Ywhaz Gys1 Slc2a4 Stxbp4 Stx4a Trip10 Sfn Ins2 Insr Prkcz Akt1 Rhoq Prkci Ywhae Akt2 Ywhab Gm14226 Ppp1cc Ppp1r3a Tbc1d4 a Ywhah Lnpep Ywhag Vamp2 PID_CASPASE_PATHWAY%MSIGDB_C2%PID_CASPASE_PATHWAY PID_CASPASE_PATHWAY Prf1 Gzmb Acta1 Dffa Dffb Birc2 Casp1 Arhgdib Lmna Casp2 Casp4 Srebf1 Lmnb2 Tnf Tnfrsf1a Gas2 Tfap2a Satb1 Lmnb1 Slk Xiap Cfl2 Diablo Pidd1 Traf2 Tradd Ripk1 Casp8 Top1 Numa1 Apaf1 Birc3 Casp7 Cradd Sptan1 Madd Krt18 Gsn Bcl2 Bax Parp1 App Limk1 Bid Casp6 Casp3 Casp9 Map3k1 Vim Ptk2 HALLMARK_ADIPOGENESIS%MSIGDB_C2%HALLMARK_ADIPOGENESIS HALLMARK_ADIPOGENESIS Gbe1 Slc25a1 Itih5 Plin2 Pfkl Stat5a Dnajb9 Ptrf Lifr Angptl4 Sorbs1 Ccng2 Acadl Echs1 Acadm Acads Dld Aifm1 Adipor2 Idh3g Ifngr1 Hadh Mylk Ucp2 Riok3 Cmbl Cmpk1 Cyp4b1 Esyt1 Mgst3 Chchd10 Samm50 Pim3 Slc19a1 Lama4 Cd302 Cd36 Lep Col4a1 Adipoq Chuk Me1 Reep5 Uqcrc1 Tkt Cyc1 Bcl2l13 Enpp2 Fabp4 Pgm2 Phldb1 Tank Ndufb7 Agpat6 Retn Agpat3 Sncg Araf Elmod3 Uqcr10 Ptcd3 Sdhb Slc25a10 Rreb1 G3bp2 Cox8a Sdpr Qdpr Vegfb Uck1 Immt Coq9 Ndufab1 Dram2 Coq5 Ndufa5 Rnf11 Cd151 Rmdn3 Nabp1 Pfkfb3 Rtn3 Dlat Scarb1 Sult1a1 Phyh Gadd45a Coq3 Preb Dbt Ak2 Atp1b3 Sqrdl C3 Ppm1b Stom Aldoa Atl2 Gphn Prdx3 Bckdha Ubc Lipe Fzd4 Cox6a1 Arl4a Tst Ppp1r15b Rab34 Pqlc3 Bcl6 Dhrs7b Adcy6 Slc27a1 Slc5a6 Orm3 Ghitm Esrra Dnajc15 Pdcd4 Gpam Baz2a Adig Grpel1 Mtch2 Acly Sowahc Fam73b Uqcrq Omd Aplp2 Ubqln1 Marc2 Taldo1 Abcb8 Nkiras1 Lpcat3 Mccc1 Cox7b Etfb Elovl6 Abca1 Idh3a Dgat1 Tob1 Mrap Ptger3 Jagn1 Itga7 Ywhag Cs Ddt Map4k3 Aldh2 Cdkn2c Nmt1 Pemt Gpx4 Gpx3 Sparcl1 Slc1a5 Fah Por Mgll Sdhc Itsn1 Mdh2 Pex14 Angpt1 Scp2 Gpd2 Cidea Sspn Cat Cpt2 Hspb8 Hibch Crat Reep6 Ltc4s Decr1 Acaa2 Suclg1 Acox1 Ech1 Dhcr7 Lpl Ephx2 Col15a1 Apoe Retsat Dhrs7 Aco2 Pparg Idh1 BIOCARTA_STATHMIN_PATHWAY%MSIGDB_C2%BIOCARTA_STATHMIN_PATHWAY BIOCARTA_STATHMIN_PATHWAY Prkar2a Camk2a Cd2 Prkar2b Mapk13 Camk2b Camk4 Camk2d Camk2g Prkar1b Cd247 Prkar1a Cd3d Prkacb Cd3g Cd3e Cdk1 PID_HNF3A_PATHWAY%MSIGDB_C2%PID_HNF3A_PATHWAY PID_HNF3A_PATHWAY Vtn Ap1b1 Serpina1d Crebbp Serpina1a Cyp2c55 Ep300 Ncoa3 Shh Nr2f2 Nfia Nfic Cebpb Foxa1 Apob Pisd Pou2f1 Sftpa1 Foxa3 Foxa2 Gcg Col18a1 Ins2 Fos Atp5j Nkx3-1 Ndufv3 Ar Xbp1 Prdm15 Nrip1 Scgb1a1 Jun Sp1 Cdkn1b Esr1 Brca1 Sftpd Dscam BIOCARTA_PDGF_PATHWAY%MSIGDB_C2%BIOCARTA_PDGF_PATHWAY BIOCARTA_PDGF_PATHWAY Sos1 Jak1 Stat2 Pdgfa Pdgfra Stat6 Prkca Map2k1 Shc1 Rasa1 Stat5b Hras Stat5a Stat4 Srf Plcg1 Pik3ca Fos Map2k4 Pik3r1 Mapk8 Stat1 Stat3 Grb2 Jun Pik3cg Elk1 Prkcb Map3k1 Mapk3 Raf1 HALLMARK_UNFOLDED_PROTEIN_RESPONSE%MSIGDB_C2%HALLMARK_UNFOLDED_PROTEIN_RESPONSE HALLMARK_UNFOLDED_PROTEIN_RESPONSE Atf6 Chac1 Sdad1 Dctn1 Exosc4 Serp1 Eif4a1 Exosc5 Ywhaz Exosc9 Sec31a Hyou1 Ern1 Spcs3 Rps14 Sec11a Cebpg Yif1a Skiv2l2 Shc1 Ddx10 Imp3 Edc4 Cebpb Bag3 Nhp2 Slc7a5 Cnot2 Cxxc1 Exoc2 Ddit4 Dnajb9 Cnot4 Cnot6 Exosc2 Atf3 Exosc1 Eif4ebp1 Nfya Nop56 Paip1 Nfyb Pop4 Eif4a3 Slc1a4 Atp6v0d1 Ccl12 Atf4 Wipi1 Dcp1a Eif2ak3 Srprb Eif4e Spcs1 Dnaja4 Dcp2 Edem1 Tubb2a Eef2 Hspa5 Stc2 Kdelr3 Dnajc3 Asns Wfs1 Lsm4 Gemin4 Zbtb17 Gosr2 Lsm1 Tars Slc30a5 Aldh18a1 Mthfd2 Fus 2010002M12Rik Eif2s1 Tspyl2 Psat1 Dkc1 Hspa9 Banf1 Ttc37 Herpud1 Ssr1 Pdia6 Pdia5 Exosc10 Nop14 Calr Arfgap1 Tatdn2 Parn Fkbp14 Srpr Igfbp1 Kif5b Nolc1 Xpot H2afx Vegfa Iars Eif4a2 Rrp9 Nabp1 Preb Xbp1 Eif4g1 Ero1l Npm1 Hsp90b1 Cks1b BIOCARTA_TH1TH2_PATHWAY%MSIGDB_C2%BIOCARTA_TH1TH2_PATHWAY BIOCARTA_TH1TH2_PATHWAY Cd40 H2-Eb1 Il4ra Cd40lg Il4 Il2ra Ifng Il2 Il12b Cd86 Il12a Ifngr1 Il12rb2 Ifngr2 Il18r1 Il18 Il12rb1 PID_HIF2PATHWAY%MSIGDB_C2%PID_HIF2PATHWAY PID_HIF2PATHWAY Slc11a2 Slc2a1 Crebbp Egln2 Ets1 Ep300 Sirt1 Twist1 Pgk1 Abcg2 Apex1 Efna1 Arnt Epo Vhl Egln3 Bhlhe40 Cited2 Elk1 Sp1 Kdr Epas1 Tceb1 Eif3e Vegfa Fxn Adora2a Flt1 Hif1an Mmp14 Serpine1 Pou5f1 PID_ARF6_TRAFFICKING_PATHWAY%MSIGDB_C2%PID_ARF6_TRAFFICKING_PATHWAY PID_ARF6_TRAFFICKING_PATHWAY Slc2a4 Dnm2 Exoc1 Il2ra Exoc6 Exoc5 Exoc4 Exoc7 Exoc2 Exoc3 Itgb1 Nme1 Ctnna1 Itga5 Rala Tshr Spag9 Scamp2 Asap2 Itga11 Adrb2 Vamp3 Itga10 Cpe Itga8 Mapk8ip3 Itga9 Pld2 Itga6 Itga7 Pld1 Itga4 Klc1 Bin1 Avpr2 Acap1 Itga2 Itga1 Itga3 Ctnnb1 Ctnnd1 Pip5k1c Cdh1 Arf6 Cltc Ins2 Ednrb Agtr1a Itgav HALLMARK_WNT_BETA_CATENIN_SIGNALING%MSIGDB_C2%HALLMARK_WNT_BETA_CATENIN_SIGNALING HALLMARK_WNT_BETA_CATENIN_SIGNALING Axin1 Axin2 Lef1 Fzd1 Hdac2 Wnt1 Hdac5 Skp2 Tcf7 Ptch1 Jag1 Ctnnb1 Notch1 Trp53 Adam17 Ncor2 Maml1 Ppard Rbpj Dvl2 Dll1 Psen2 Csnk1e Kat2a Myc Ccnd2 Notch4 Numb Nkd1 Fzd8 Jag2 Cul1 Ncstn Dkk1 Dkk4 Hdac11 Wnt5b Gnai1 Wnt6 Hey1 Hey2 PID_NFAT_3PATHWAY%MSIGDB_C2%PID_NFAT_3PATHWAY PID_NFAT_3PATHWAY Gsk3b Ywhaz Prkca Camk4 Bcl2l1 Mapk14 Pim1 Rcan1 Chp1 Rcan2 Csnk1a1 Fkbp8 Prkaca Sfn Akap5 Ppp3r1 Nr4a1 Mapk8 Ywhae Ywhab Nup214 Mapk3 Ran Ywhah Ywhag Cabin1 Prkch Prkce Crebbp Prkcq Ep300 Mef2d Nfatc3 Nfatc1 Prkcd Nfatc2 Bad Prkcz Fkbp1a Mapk9 Bcl2 Bax Ppp3ca Casp3 Ppp3cb Xpo1 Prkcg Map3k8 Prkcb Map3k1 Kpnb1 BIOCARTA_ETC_PATHWAY%MSIGDB_C2%BIOCARTA_ETC_PATHWAY BIOCARTA_ETC_PATHWAY Sdhb Atp5a1 Uqcrc1 Slc25a4 Gpd2 Sdhd Sdha Sdhc mt-Co1 Slc25a5 Ndufa1 ST_INTERFERON_GAMMA_PATHWAY%MSIGDB_C2%ST_INTERFERON_GAMMA_PATHWAY ST_INTERFERON_GAMMA_PATHWAY Ifng Jak1 Elp2 Cish Ptpru Ifngr1 Reg1 Stat1 Jak2 PID_ARF6_PATHWAY%MSIGDB_C2%PID_ARF6_PATHWAY PID_ARF6_PATHWAY Gulp1 Adap1 Iqsec1 Kif13b Arrb1 Hgf Arrb2 Cyth3 Acap2 Fbxo8 Lhcgr Ipcef1 Arap2 Met Src Epha2 Itgb3 Egf Git1 Arf6 Pxn Efna1 Itga2b Gnaq Cyth2 Nck1 Gna11 Tshr Egfr Agtr1a Adrb2 Gna14 Acap1 Gna15 BIOCARTA_RAB_PATHWAY%MSIGDB_C2%BIOCARTA_RAB_PATHWAY BIOCARTA_RAB_PATHWAY Rab5a Rab7 Rab3a Acta1 Rab8a Rab6a Rab2a Rab9 Rab27a Rab1 Rab11a Rab4a SA_REG_CASCADE_OF_CYCLIN_EXPR%MSIGDB_C2%SA_REG_CASCADE_OF_CYCLIN_EXPR SA_REG_CASCADE_OF_CYCLIN_EXPR E2f4 Ccna2 Gm8882 Ccne2 Cdkn2a Ccne1 Cdk4 E2f2 E2f1 Ccna1 Cdkn1b Ccnd1 Cdk2 BIOCARTA_NFAT_PATHWAY%MSIGDB_C2%BIOCARTA_NFAT_PATHWAY BIOCARTA_NFAT_PATHWAY Prkar2a Igf1 Gsk3b Crebbp Prkar2b Camk1g Acta1 Camk1 Camk4 Map2k1 Mapk14 Ctf1 Hras Nfatc3 Nfatc1 Csnk1a1 Nfatc2 Prkacb Pik3ca Hbegf Gata4 Fkbp1a F2 Myh2 Akt1 Fgf2 Lif Pik3r1 Nfatc4 Mapk8 Ppp3cc Ppp3ca Nkx2-5 Ppp3cb Nppa Prkar1b Hand2 Pik3cg Agt Hand1 Prkar1a Edn1 Mapk1 Mapk3 Calr Mef2c Raf1 BIOCARTA_IL2RB_PATHWAY%MSIGDB_C2%BIOCARTA_IL2RB_PATHWAY BIOCARTA_IL2RB_PATHWAY Sos1 Il2rg Jak1 Jak3 Ppia Shc1 Il2ra Bcl2l1 Fas Fasl Stat5b Stat5a Hras Pik3ca Fos Bad Myc Syk Crkl Akt1 Ptpn6 Bcl2 Pik3r1 Ikzf3 Socs3 Grb2 E2f1 Pik3cg Cflar Nmi Irs1 Mapk1 Socs1 Mapk3 Cbl Il2rb Raf1 BIOCARTA_GH_PATHWAY%MSIGDB_C2%BIOCARTA_GH_PATHWAY BIOCARTA_GH_PATHWAY Sos1 Slc2a4 Ghr Prkca Rps6ka1 Map2k1 Shc1 Stat5b Hras Stat5a Srf Plcg1 Pik3ca Ins2 Insr Jak2 Ptpn6 Pik3r1 Hnf1a Grb2 Pik3cg Prkcb Irs1 Mapk1 Socs1 Mapk3 Raf1 PID_INTEGRIN_A4B1_PATHWAY%MSIGDB_C2%PID_INTEGRIN_A4B1_PATHWAY PID_INTEGRIN_A4B1_PATHWAY Ywhaz Vcam1 Adam28 Cd14 Src Git1 Arf6 Prkacb Pxn Prkaca Itgb1 Bcar1 Cd81 Tln1 Amica1 Myh2 Igsf8 Crk Jam2 Abi1 Ptpra Fn1 Mdk Prkar1b Thbs2 Thbs1 Prkar1a Ptk2b Ptk2 Dock1 Itga4 Spp1 Rac1 PID_SYNDECAN_2_PATHWAY%MSIGDB_C2%PID_SYNDECAN_2_PATHWAY PID_SYNDECAN_2_PATHWAY Csf2 Sdcbp Rasa1 Epb4.1 Hras Src Gnb2l1 Prkcd Ephb2 Lama3 Mmp2 Prkaca Itgb1 Cask Trappc4 Cav2 Sdc2 Ezr Lama1 Bax Mapk8 Itga5 Casp3 Rhoa Fn1 Tnfrsf13b Tgfb1 Mapk1 Nf1 Mapk3 Itga2 Kng2 PID_IL8_CXCR1_PATHWAY%MSIGDB_C2%PID_IL8_CXCR1_PATHWAY PID_IL8_CXCR1_PATHWAY Plcb3 Prkce Gnai2 Arrb1 Pik3r6 Arrb2 Prkca Gnb1 Pdpk1 Cxcr1 Akt1 Hck Dnm1 Prkcg Adrbk1 Pik3cg Rab5a Prkcb Fgr Lyn Gna14 Gng2 Pld1 Plcb1 Cbl Gna15 Plcb2 NABA_COLLAGENS%MSIGDB_C2%NABA_COLLAGENS NABA_COLLAGENS Col23a1 Col20a1 Col13a1 Col19a1 Col24a1 Col7a1 Col6a6 Col14a1 Col6a1 Col5a1 Col17a1 Col10a1 Col25a1 Col2a1 Col4a4 Col4a2 Col4a3 Col28a1 Col4a1 Col8a2 Col15a1 Col18a1 Col16a1 Col1a2 Col22a1 Col9a1 Col9a2 Col5a3 Col5a2 Col11a1 Col8a1 Col11a2 Col9a3 Col4a5 Col12a1 Col27a1 Col4a6 Col6a3 Col6a2 Col3a1 Col26a1 Col1a1 BIOCARTA_MONOCYTE_PATHWAY%MSIGDB_C2%BIOCARTA_MONOCYTE_PATHWAY BIOCARTA_MONOCYTE_PATHWAY Icam1 Sell Itgal Selp Pecam1 Sele Cd44 Itgb1 Itgam Itga4 Itgb2 PID_IL27_PATHWAY%MSIGDB_C2%PID_IL27_PATHWAY PID_IL27_PATHWAY Il1b Il6st Jak1 Il6 Stat2 Ebi3 Ifng Il12b Il2 Il17a Stat5a Stat4 Gata3 Tyk2 Il12a Il12rb2 Il27 Jak2 Il18 Tnf Il12rb1 Stat1 Il27ra Stat3 Tbx21 Tgfb1 PID_EPHA_FWDPATHWAY%MSIGDB_C2%PID_EPHA_FWDPATHWAY PID_EPHA_FWDPATHWAY Rock1 Efna5 Pik3r6 Epha3 Efna2 Ngef Epha6 Epha8 Epha1 Epha7 Yes1 Src Epha2 Plcg1 Blk Epha4 Efna1 Crkl Crk Cdk5 Hck Epha5 Lck Fyn Rhoa Vav3 Pik3cg Fgr Efna3 Lyn Pik3r5 Cbl Arhgef15 Vav2 BIOCARTA_IGF1R_PATHWAY%MSIGDB_C2%BIOCARTA_IGF1R_PATHWAY BIOCARTA_IGF1R_PATHWAY Sos1 Igf1r Adcy1 Prkar2a Prkar2b Akt1 Pik3r1 Grb2 Rps6ka1 Shc1 Prkar1b Map2k1 Prkar1a Hras Prkacb Pik3ca Irs1 Mapk1 Mapk3 Ywhah Bad Raf1 BIOCARTA_INTRINSIC_PATHWAY%MSIGDB_C2%BIOCARTA_INTRINSIC_PATHWAY BIOCARTA_INTRINSIC_PATHWAY F2 F2r F10 Pros1 Serpinc1 Col4a5 F12 F5 F8 Col4a6 Serping1 Col4a4 Col4a2 Col4a3 Col4a1 F9 Proc Fga Fgb Fgg F11 Kng2 Klkb1 PID_AURORA_A_PATHWAY%MSIGDB_C2%PID_AURORA_A_PATHWAY PID_AURORA_A_PATHWAY Cenpa Gsk3b Cdc25b Pak1 Rasa1 Birc5 Git1 Trp53 Ppp2r5d Prkaca Tacc3 Aurkb Tpx2 Mdm2 Gadd45a Akt1 Aurka Dlgap5 Oaz1 Fzr1 Aurkaip1 Ajuba Tdrd7 Tacc1 Nfkbia Ndel1 Ckap5 Cpeb1 Brca1 Arhgef7 Ran PID_A6B1_A6B4_INTEGRIN_PATHWAY%MSIGDB_C2%PID_A6B1_A6B4_INTEGRIN_PATHWAY PID_A6B1_A6B4_INTEGRIN_PATHWAY Erbb3 Cd9 Ywhaz Il1a Lama4 Lamc3 Prkca Col17a1 Casp7 Lama5 Shc1 Lamc2 Met Lamc1 Hras Egf Cdh1 Lama3 Itgb4 Pik3ca Itgb1 Sfn Mst1 Akt1 Lama1 Pik3r1 Rxrg Ywhae Grb2 Lama2 Ywhab Egfr Rxra Lamb3 Mst1r Erbb2 Itga6 Lamb1 Ywhah Ywhag Rxrb Pmp22 Lamb2 Rac1 PID_SMAD2_3NUCLEAR_PATHWAY%MSIGDB_C2%PID_SMAD2_3NUCLEAR_PATHWAY PID_SMAD2_3NUCLEAR_PATHWAY Hdac2 Cbfb Ncor1 Creb1 Runx2 Ncoa2 Itgb5 Foxo4 Hnf4a Tfdp1 Smad4 Lamc1 Cebpb Ctbp1 Sap30 Pias4 Tgif1 Atf3 Fos Foxo1 Tcf3 Cited1 Akt1 Dlx1 Rbbp7 Dcp1a Snip1 Med15 Foxg1 Smad3 Runx3 Foxo3 Foxh1 Sin3b Smad2 Gm10094 Smad7 Irf7 Kat2b Ifnb1 Crebbp Vdr Myod1 Ep300 Il10 Il5 Tgif2 Sin3a E2f5 Gata3 Skil Sp3 Hspa8 Cdk2 Rbl1 Myc Kat2a Nr3c1 Col1a2 E2f4 Tfe3 Zbtb17 Hdac1 Ar Cdkn2b Cdk4 Pias3 Ncoa1 Nkx2-5 Ski Cdkn1a Atf2 Jun Gsc Sp1 Esr1 Max Mef2c Serpine1 Rbbp4 HALLMARK_ESTROGEN_RESPONSE_LATE%MSIGDB_C2%HALLMARK_ESTROGEN_RESPONSE_LATE HALLMARK_ESTROGEN_RESPONSE_LATE Car2 Isg20 Wisp2 Fkbp5 Cish Slc26a2 Fabp5 Fos Abhd2 Jak2 Celsr2 Serpina3n Zfp36 Ccna1 Large Serpina5 Il6st Slc9a3r1 Cd44 Hmgcs2 Slc22a5 Il17rb Tpbg Myb Aldh3a2 Blvrb Rbbp8 Krt13 Fgfr3 Cdc20 Egr3 Cdc6 Tiam1 Top2a Mapk13 Batf Hspa4l Gal Mest Mocs2 Tpsb2 Mdk Impa2 Cav1 Jak1 Cxcl14 Siah2 Cdh1 Fkbp4 Scarb1 Xbp1 Nrip1 Pgr Areg Gins2 Tst Car12 Rps6ka2 Slc29a1 Abca3 Pdcd4 Lamc2 Slc7a5 Ascl1 Ncor2 Plk4 Cxcl12 Sfn Chpt1 Slc1a4 Add3 Xrcc3 Etfb Ovol2 Tob1 Gla Ptger3 Sgk1 Opn3 S100a9 Tjp3 Amfr Aldh3b1 Nbl1 Slc24a3 Cyp26b1 Igsf1 Rabep1 Rab31 Pkp3 Hprt Rapgefl1 Ltf Dusp2 Hr Tspan13 Nmu Pdzk1 Pcp4 Npy1r Llgl2 Tsta3 Frk Dnajc12 Gjb3 Lsr Dynlt3 Gale Ugdh Flnb Slc2a8 Cyp4f40 Ppif Unc13b Mettl3 Dnajc1 Itpk1 Plxnb1 Slc16a1 Plac1 Arl3 Prlr Nab2 Stil Rnaseh2a Dcxr Btg3 Emp2 Klk11 Ccnd1 Atp2b4 Pla2g16 St6galnac2 Foxc1 Acox2 Dlg5 Agr2 Wfs1 Gper1 Olfm1 Clic3 Tmprss3 Prss23 Ptpn6 Snx10 Bcl2 Cacna2d2 Farp1 Ass1 Chst8 Myof Tfap2c Aff1 Ret Scnn1a Mill2 Tff3 Fam102a Kcnk5 Klk10 Sox3 Calcr Bag1 Serpina1d Serpina1a Prkar2b Anxa9 Tfpi2 Id2 Igfbp4 Tnnc1 Sult2b1 Hspb8 Cpe Papss2 Cd9 Dhcr7 Perp Th Tpd52l1 Nxt1 Slc27a2 Ckb Elovl5 Fdft1 Idh2 Sema3b Ptges Klf4 Homer2 St14 Kif20a Sord BIOCARTA_GSK3_PATHWAY%MSIGDB_C2%BIOCARTA_GSK3_PATHWAY BIOCARTA_GSK3_PATHWAY Apc Axin1 Lef1 Gsk3b Fzd1 Wnt1 Dvl1 Myd88 Ctnnb1 Pdpk1 Cd14 Eif2ak2 Pik3ca Ccnd1 Gja1 Akt1 Ly96 Pik3r1 Lbp Ppp2ca Rela Nfkb1 Tlr4 Tollip Gnai1 Irak1 Tirap BIOCARTA_AKAP13_PATHWAY%MSIGDB_C2%BIOCARTA_AKAP13_PATHWAY BIOCARTA_AKAP13_PATHWAY Lpar2 Lpar3 Prkar2a Prkar2b Gna13 Gna12 Prkag1 Prkacb Akap13 Rhoa Lpar1 BIOCARTA_CFTR_PATHWAY%MSIGDB_C2%BIOCARTA_CFTR_PATHWAY BIOCARTA_CFTR_PATHWAY Prkar1b Adcy1 Prkar1a Ezr Prkar2a Cftr Prkar2b Adrb2 Slc9a3r1 Prkacb BIOCARTA_EDG1_PATHWAY%MSIGDB_C2%BIOCARTA_EDG1_PATHWAY BIOCARTA_EDG1_PATHWAY Adcy1 Pdgfa Pdgfra Prkca Gnb1 Src Itgb3 Smpd2 Pik3ca Akt1 S1pr1 Pik3r1 Sphk1 Rhoa Pik3cg Prkcb Asah1 Sphkap Gngt1 Ptk2 Smpd1 Gnai1 Mapk1 Itgav Mapk3 Plcb1 Rac1 PID_BCR_5PATHWAY%MSIGDB_C2%PID_BCR_5PATHWAY PID_BCR_5PATHWAY Sos1 Ibtk Bcl2a1d Ikbkb Pik3ap1 Cd72 Fcgr2b Dapp1 Card11 Camk2g Shc1 Map2k1 Cd79a Bcl10 Cd79b Mapk14 Pdpk1 Hras Fos Cd22 Syk Akt1 Dok1 Ptprc Mapk8 Inpp5d Pag1 Pten Nfkbib Sh3bp5 Traf6 Csk Nfkbia Ikbkg Rela Nfkb1 Malt1 Mapk1 Mapk3 Chuk Raf1 Vav2 Rac1 Pou2f2 Ets1 Rasa1 Nfatc1 Pik3ca Map4k1 Btk Plcg2 Ptpn6 Pik3r1 Ppp3cc Ppp3ca Grb2 Ppp3cb Cd19 Jun Elk1 Map3k1 Lyn Map3k7 Blnk PID_CD40_PATHWAY%MSIGDB_C2%PID_CD40_PATHWAY PID_CD40_PATHWAY Jak3 Fcamr Tdp2 Cblb Birc2 Birc3 Cd40lg Il4 Bcl2l1 Mapk14 Tnfaip3 Traf1 Stat5a Myc Mapk10 Cd40 Mapk11 Mapk9 Akt1 Map2k4 Mapk8 Traf2 Jun Traf3 Map3k14 Traf6 Map3k1 Nfkbia Rela Nfkb1 BIOCARTA_FIBRINOLYSIS_PATHWAY%MSIGDB_C2%BIOCARTA_FIBRINOLYSIS_PATHWAY BIOCARTA_FIBRINOLYSIS_PATHWAY Plg F2 F2r Plau Serpinb2 Cpb2 Plat Fga F13a1 Fgb Fgg Serpine1 HALLMARK_INTERFERON_GAMMA_RESPONSE%MSIGDB_C2%HALLMARK_INTERFERON_GAMMA_RESPONSE HALLMARK_INTERFERON_GAMMA_RESPONSE Isg20 Rsad2 Arid5b Ifi35 Ifih1 Il10ra Gbp3 Pim1 Trafd1 Irf8 Ptpn1 Csf2rb2 Casp4 Jak2 Lats2 Ccl12 Btg1 Nup93 Pde4b Tor1b Bank1 Peli1 Ciita Sppl2a Cmklr1 Fcgr1 Sri Oas3 Oas2 C1rb Stat1 Tnfaip2 Eif4e3 Stat3 Zbp1 Gpr18 Rbck1 Il18bp Sectm1a H2-Q1 Pla2g4a Rapgef6 Rnf213 Apol6 P2ry14 Pnp Nod1 Vamp5 Vamp8 Gbp9 Lysmd2 Usp18 Psmb9 Il15ra Psmb8 Parp14 Cxcl11 Samd9l Cxcl10 Parp12 Lap3 Isg15 Irf2 Oasl1 Ly6e Myd88 Txnip Casp7 Cmtr1 Rtp4 Ube2l6 Cxcl9 Pnpt1 Ifi44 Bst2 Lgals3bp Irf1 Batf2 Slc25a28 Ccl7 Sp110 Ptpn2 Bpgm Cmpk2 Ddx60 C1s2 Il7 Mthfd2 Helz2 Cd38 Ifi30 2010002M12Rik Ifit3b Trim25 Trim21 Dhx58 Trim26 Cdkn1a Psme2 Adar Fpr1 Nmi Rnf31 Tdrd7 Trim14 Epsti1 Ogfr Ifi27 Ptgs2 Herc6 Ifitm3 Ifitm2 Ifit2 Icam1 Selp Cd40 Itgb7 Hif1a Il6 Il4ra H2-Eb1 Slamf7 March1 Ddx58 St3gal5 Cd69 Psmb2 Ifnar2 Ido1 Mettl7b Irf5 Eif2ak2 Klrk1 Nampt Samhd1 Gzma B2m Arl4a Mt2 Cd274 Ripk2 H2-Q10 Psma2 Socs1 Il2rb Lcp2 Irf4 Cd74 Ncoa3 Pml St8sia4 Fgl2 Wars Tnfaip6 Tnfsf10 Ripk1 Cd86 Casp8 Irf7 H2-DMa Xcl1 Irf9 Stat2 Tnfaip3 Psmb10 Stat4 Tap1 Ptpn6 H2-Aa Ccl5 Serping1 Casp3 Socs3 Tapbp Pfkp H2-M3 Cfh Vcam1 Casp1 Fas Cfb Znfx1 Sspn Upp1 Nfkbia Psme1 Nfkb1 Gch1 Mvp Il15 Isoc1 Sod2 Plscr1 Psma3 PID_TAP63_PATHWAY%MSIGDB_C2%PID_TAP63_PATHWAY PID_TAP63_PATHWAY Sspo Ikbkb Cdkn2a Vdr Itga3 Cables1 Gdf15 Spata18 Traf4 Ep300 Serpinb5 Ssrp1 Ogg1 Perp Aen Shh Evpl Dicer1 Gpx2 Fas Jag1 Igfbp3 Smarcd3 Pml Clca2 Egr2 Prkcd Ada Trp63 Itgb4 Plk1 Flot2 Mdm2 Dhrs3 Wwp1 Gadd45a Itch Bax Tfap2c Cdkn1a Hbp1 Mfge8 Sp1 Nqo1 Fdxr Chuk Abl1 PID_DNA_PK_PATHWAY%MSIGDB_C2%PID_DNA_PK_PATHWAY PID_DNA_PK_PATHWAY Lig4 Csnk2b Xrcc4 Aptx Pnkp Dntt Poll Prkdc Aplf Xrcc5 Xrcc6 Polm Dclre1c Csnk2a2 BIOCARTA_TNFR2_PATHWAY%MSIGDB_C2%BIOCARTA_TNFR2_PATHWAY BIOCARTA_TNFR2_PATHWAY Tnfrsf1b Ikbkb Dusp1 Ikbkap Tank Lta Traf2 Traf3 Tnfaip3 Map3k14 Traf1 Map3k1 Nfkbia Ikbkg Ripk1 Rela Nfkb1 Chuk BIOCARTA_TFF_PATHWAY%MSIGDB_C2%BIOCARTA_TFF_PATHWAY BIOCARTA_TFF_PATHWAY Sos1 Akt1 Apaf1 Pik3r1 Ghr Grb2 Rhoa Casp9 Shc1 Pik3cg Ctnnb1 Egfr Hras Ptk2 Pik3ca Mapk1 Mapk3 Itgb1 Bad BIOCARTA_IL22BP_PATHWAY%MSIGDB_C2%BIOCARTA_IL22BP_PATHWAY BIOCARTA_IL22BP_PATHWAY Jak1 Jak3 Stat2 Iltifb Il22ra2 Stat6 Stat1 Il22ra1 Stat3 Socs3 Il10ra Stat5b Stat5a Stat4 Tyk2 Jak2 BIOCARTA_CSK_PATHWAY%MSIGDB_C2%BIOCARTA_CSK_PATHWAY BIOCARTA_CSK_PATHWAY Cd4 Adcy1 Prkar2a Prkar2b Crebbp Lck Ptprc H2-Eb1 Zap70 Gnb1 Prkar1b Cd247 Prkar1a Csk Cd3d Gngt1 Prkacb Cd3g Cd3e PID_IL5_PATHWAY%MSIGDB_C2%PID_IL5_PATHWAY PID_IL5_PATHWAY Sdcbp Pik3r1 Il5ra Il5 Grb2 Ptpn11 Pim1 Stat5b Stat5a Cish Lyn Pik3ca Csf2rb2 Jak2 PID_P38_MK2_PATHWAY%MSIGDB_C2%PID_P38_MK2_PATHWAY PID_P38_MK2_PATHWAY Mapk11 Creb1 Ywhaz Cdc25b Tsc2 Hspb1 Etv1 Ywhae Mapk14 Th Ywhab Srf Lsp1 Ywhah Sfn Mapkapk3 Ywhag Mapkapk2 Raf1 Tcf3 BIOCARTA_TOLL_PATHWAY%MSIGDB_C2%BIOCARTA_TOLL_PATHWAY BIOCARTA_TOLL_PATHWAY Tab2 Ikbkb Tlr6 Tlr3 Tlr2 Myd88 Mapk14 Cd14 Eif2ak2 Map2k6 Fos Ly96 Map2k3 Map2k4 Mapk8 Ecsit Jun Tlr9 Map3k14 Elk1 Traf6 Nfkbia Map3k1 Ikbkg Tlr7 Pglyrp1 Rela Tab1 Tlr4 Nfkb1 Tollip Irak1 Tirap Chuk Map3k7 Ppara HALLMARK_INFLAMMATORY_RESPONSE%MSIGDB_C2%HALLMARK_INFLAMMATORY_RESPONSE HALLMARK_INFLAMMATORY_RESPONSE Klf6 Slc11a2 Mefv Chst2 Il10ra Osm Ccl12 Pde4b Tnfrsf1b Cmklr1 Sri Rhog Nod2 Osmr Ptgir Il15ra Cxcl11 Cxcl10 Sele Csf1 Icam4 Ebi3 Gp1ba Ly6e Tlr2 Rtp4 Lamp3 Csf3r Tpbg Cd14 Btg2 Itgb3 Cxcl9 Ifngr2 Adora2b Bst2 Acvr1b Ccrl2 Irf1 Ccl7 Cdkn1a Fpr1 Nmi Atp2b1 Edn1 Serpine1 Icam1 Sell Ereg Csf3 Il1a Fzd5 Vip Tnfsf15 Cd40 Hif1a Abi1 Gnai3 Sphk1 Rela Ccl22 Ccl24 Ccl20 Lpar1 Il1b Il6 Gpc3 F3 Il4ra Met Cd69 Eif2ak2 Nampt Lck Adm Il18rap Ripk2 Il1r1 Il2rb Lcp2 Tlr3 Tlr1 Nlrp3 Cd82 Psen1 Tnfaip6 Lif Rgs1 Mxd1 Tnfsf10 Abca1 Acvr2a Rasgrp1 Irf7 Pik3r5 Raf1 Cxcl5 Vimp P2ry2 Ifnar1 Cx3cl1 Oprk1 Aqp9 Il12b Il18r1 Hbegf Myc Il18 Mep1a Icosl Olr1 Slc7a2 Ccl5 Tapbp Stab1 Inhba Lyn Slc7a1 Cybb Ccl17 Gna15 Mmp14 Cd70 Irak2 Scarf1 Ptger2 Clec5a Ptger4 Tnfrsf9 Ptafr Best1 Hpn Slc4a4 Atp2c1 P2rx4 P2rx7 Tacr1 Bdkrb1 Tacr3 C5ar1 Kif1b Adgre1 Sema4d Gpr183 Cxcr6 Itga5 Ahr Kcnmb2 Slc28a2 Itgb8 Kcnj2 Emp3 Nmur1 Rgs16 Nfkbia Hrh1 Il7r Msr1 Gabbr1 Nfkb1 Slamf1 Pdpn Atp2a2 Scn1b Ndp Gch1 Pcdh7 Slc31a1 Slc31a2 Adrm1 Lta Il10 Aplnr Axl Il15 Cd48 Ccr7 Sgms2 Has2 Slc1a2 Calcrl Rnf144b Ffar2 Gpr132 Plaur C3ar1 Npffr2 Dcbld2 Ros1 Prok2 Kcna3 Marco Timp1 Ptpre Ldlr ST_IL_13_PATHWAY%MSIGDB_C2%ST_IL_13_PATHWAY ST_IL_13_PATHWAY Jak1 Tyk2 Il13ra1 Il13ra2 Jak2 Il4ra Il13 PID_CD8_TCR_DOWNSTREAM_PATHWAY%MSIGDB_C2%PID_CD8_TCR_DOWNSTREAM_PATHWAY PID_CD8_TCR_DOWNSTREAM_PATHWAY Prf1 Gzmb Tnfrsf9 Prkca Map2k1 Il2ra Map2k2 Il2 Fasl Junb Hras Egr1 Braf Fos Ppp3r1 Tnf Mapk8 Nras Mapk1 Mapk3 Raf1 Il2rg Prkce Prkcq Ifnar1 Ifna16 Tnfrsf4 Egr4 Tnfrsf18 Ifng Cd247 Cd3d Nfatc3 Ifnar2 Nfatc1 Fosl1 Stat4 Ptpn7 Nfatc2 Cd3g Cd3e Mapk9 Cd8b1 Kras Ppp3ca Ppp3cb Jun B2m Elk1 Prkcb H2-Q10 Eomes Il2rb Cd8a BIOCARTA_IL1R_PATHWAY%MSIGDB_C2%BIOCARTA_IL1R_PATHWAY BIOCARTA_IL1R_PATHWAY Irak3 Il1b Irak2 Il1rap Il6 Ikbkb Ifnb1 Il1a Ifna16 Myd88 Mapk14 Map2k6 Tnf Tgfb2 Map2k3 Mapk8 Ecsit Jun Map3k14 Traf6 Map3k1 Nfkbia Il1rn Tgfb1 Rela Tab1 Nfkb1 Tgfb3 Tollip Il1r1 Irak1 Chuk Map3k7 BIOCARTA_CCR5_PATHWAY%MSIGDB_C2%BIOCARTA_CCR5_PATHWAY BIOCARTA_CCR5_PATHWAY Gnaq Mapk8 Prkca Jun Mapk14 Ccr5 Prkcb Ptk2b Ccl4 Plcg1 Cxcl12 Fos Cxcr4 Ccl12 BIOCARTA_CDK5_PATHWAY%MSIGDB_C2%BIOCARTA_CDK5_PATHWAY BIOCARTA_CDK5_PATHWAY Map2k1 Map2k2 Hras Cdk5 Egr1 Cdk5r1 Mapk1 Mapk3 Raf1 Ngf Ngfr BIOCARTA_LAIR_PATHWAY%MSIGDB_C2%BIOCARTA_LAIR_PATHWAY BIOCARTA_LAIR_PATHWAY Icam1 Il6 Itgal Selp C7 Selplg Il1a C6 C3 Vcam1 Itgb1 Itga4 Hc Itgb2 Kng2 Tnf PID_RAS_PATHWAY%MSIGDB_C2%PID_RAS_PATHWAY PID_RAS_PATHWAY Sos1 Rras Prkce Camk2b Prkca Rasa1 Hras Lgals3 Prkcz Lgals1 Rasgrf1 Rasal1 Kras Grb2 Rasa2 Rasa4 Syngap1 Dab2ip Rasgrp4 Prkcb Rasgrp1 Rabgef1 Rasgrp2 Rasgrp3 Nras Nf1 Plce1 Sos2 Rin1 PID_HEDGEHOG_2PATHWAY%MSIGDB_C2%PID_HEDGEHOG_2PATHWAY PID_HEDGEHOG_2PATHWAY Ptch2 Gas1 Cdon Boc Dhh Tgfb2 Lrp2 Hhat Akt1 Arrb2 Pik3r1 Gli2 Hhip Shh Lrpap1 Pthlh Ptch1 Adrbk1 Stil Smo Pik3ca Ihh PID_VEGFR1_PATHWAY%MSIGDB_C2%PID_VEGFR1_PATHWAY PID_VEGFR1_PATHWAY Nrp1 Nrp2 Prkca Rasa1 Pdpk1 Pgf Vegfb Plcg1 Pik3ca Prkaca Cd2ap Shc2 Nos3 Hif1a Akt1 Pik3r1 Nck1 Ptpn11 Prkcb Hsp90aa1 Cav1 Vegfa Mapk1 Mapk3 Flt1 Cbl BIOCARTA_GABA_PATHWAY%MSIGDB_C2%BIOCARTA_GABA_PATHWAY BIOCARTA_GABA_PATHWAY Gabra4 Gabra5 Gabra3 Src Dnm1 Gabra1 Gabra2 Gphn Gabarap Gabra6 PID_ERBB1_INTERNALIZATION_PATHWAY%MSIGDB_C2%PID_ERBB1_INTERNALIZATION_PATHWAY PID_ERBB1_INTERNALIZATION_PATHWAY Chmp3 Sos1 Tsg101 Cblb Usp8 Sh3kbp1 Amph Zfyve28 Stambp Spry2 Itsn1 Eps15 Synj1 Epn1 Shc1 Hras Src Lrig1 Egf Pik3ca Sh3gl2 Pik3r3 Pik3r1 Dnm1 Pik3r2 Kras Ube2d1 Pik3cb Grb2 Pik3cd Rab5a Egfr Hgs Ptk2 Nras Ube2d3 Arhgef7 Cbl Raf1 PID_IL3_PATHWAY%MSIGDB_C2%PID_IL3_PATHWAY PID_IL3_PATHWAY Ywhaz Il3ra Bcl2l1 Shc1 Osm Pim1 Cebpb Stat5b Stat5a Cish Gab2 Prkacb Pik3ca Csf2rb2 Id1 Prkaca Jak2 Hdac1 Pik3r1 Inpp5d Grb2 Ptpn11 Cnksr1 Srp9 Ywhag BIOCARTA_TCRA_PATHWAY%MSIGDB_C2%BIOCARTA_TCRA_PATHWAY BIOCARTA_TCRA_PATHWAY Cd4 Cd247 Cd3d Lck Ptprc Cd3g H2-Eb1 Cd3e Fyn Zap70 BIOCARTA_VITCB_PATHWAY%MSIGDB_C2%BIOCARTA_VITCB_PATHWAY BIOCARTA_VITCB_PATHWAY Slc2a1 Col4a4 Slc23a1 P4hb Col4a2 Slc2a3 Col4a3 Col4a1 Col4a5 Slc23a2 Col4a6 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES%MSIGDB_C2%SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Vasp Pak6 Rock1 Pak7 Pak3 Actg1 Pak4 Pak1 Wasf1 Flnc Flna Rock2 Wasl Myh2 Akt1 Gdi2 Cfl2 Pak2 Angptl2 Limk1 Mylk Rps4x Mylk2 Acta2 Gdi1 Pfn1 Fscn1 Pfn2 Rho Fscn3 Fscn2 Actr3 Actr2 PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY%MSIGDB_C2%PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY Atf6 Creb1 Mknk1 Mapk14 Cebpb Trp53 Eif4ebp1 Slc9a1 Csnk2b Mapk11 Mitf Mapkapk5 Hspb1 Eif4e Elk4 Ddit3 Gdi1 Atf2 Jun Hbp1 Rab5a Pla2g4a Krt8 Ppargc1a Rps6ka4 Esr1 Rps6ka5 Ptgs2 Nos2 Mapkapk3 Mapkapk2 Mef2c Csnk2a2 Mef2a Usf1 BIOCARTA_AKAP95_PATHWAY%MSIGDB_C2%BIOCARTA_AKAP95_PATHWAY BIOCARTA_AKAP95_PATHWAY Ncapd2 Prkar2a Prkar2b Ppp2ca Ddx5 Akap8 Ppp1ca Prkag1 Prkacb Cdk1 PID_ILK_PATHWAY%MSIGDB_C2%PID_ILK_PATHWAY PID_ILK_PATHWAY Myl12a Gsk3b Creb1 Tns1 Parva Parvb Parvg Ctnnb1 Elmo2 Git2 Ruvbl1 Snai1 Lims2 Ppp1r14a Ppp1r14c Cdc37 Ccnd1 Zeb1 Pxn Actn1 Ppp1r14b Ilkap Rictor Tacc3 Iqgap1 Ilk Akt1 Nck2 Aurka Parp1 Ruvbl2 Ppp1r12a Rhog Xpo1 Jun Zyx Diap1 Arhgef6 Hsp90aa1 Ckap5 Arhgef7 Rac1 PID_SYNDECAN_1_PATHWAY%MSIGDB_C2%PID_SYNDECAN_1_PATHWAY PID_SYNDECAN_1_PATHWAY Col13a1 Ppib Col7a1 Sdc1 Sdcbp Col14a1 Hgf Col6a1 Col5a1 Col17a1 Col10a1 Lama5 Met Col2a1 Col4a4 Col4a3 Mmp1a Col4a1 Col8a2 Col15a1 Col16a1 Prkaca Cask Col1a2 Mmp7 Col9a1 Col9a2 Col5a2 Col11a1 Col8a1 Col11a2 Col9a3 Col4a5 Col12a1 Col4a6 Ccl5 Col6a3 Col6a2 Hpse Bsg Mmp9 Col3a1 Tgfb1 Mapk1 Col1a1 Mapk3 BIOCARTA_ARAP_PATHWAY%MSIGDB_C2%BIOCARTA_ARAP_PATHWAY BIOCARTA_ARAP_PATHWAY Gbf1 Arf1 Kdelr1 Cyth2 Arfgef1 Arfgef2 Cyth3 Gpld1 Kdelr2 Arfgap3 Cyth4 Cyth1 Asap2 Kdelr3 Arfgap1 Copa Cltb HALLMARK_IL2_STAT5_SIGNALING%MSIGDB_C2%HALLMARK_IL2_STAT5_SIGNALING HALLMARK_IL2_STAT5_SIGNALING Klf6 Csf2 Adam19 Car2 Itih5 Plin2 Il10ra Gbp3 Pim1 Cish Irf8 Hk2 Cd81 Tnfrsf1b Rora Ndrg1 Tgm2 Slc2a3 Pnp Serpinb6a Il1r2 Ccnd3 Prkch Cxcl10 Cd44 Csf1 Ltb Gata1 Tnfrsf21 Ifngr1 Ccne1 Tlr7 Itgav Ifitm3 Sell Selp Il2ra Pou2f1 Batf3 Cdc6 Tiam1 Batf Itgae Igf2r Dennd5a Snx14 Ncs1 She St3gal4 Umps Flt3l Aplp1 Irf6 Drc1 Gpr83 Twsg1 Glipr2 Capn3 Cd83 Cdc42se2 Slc39a8 Enpp1 Igf1r Dcps Nrp1 Nfkbiz Rabgap1l Myo1e Syt11 Cdcp1 N6amt2 Gucy1b3 Etv4 Phtf2 Snx9 Swap70 Il4ra Phlda1 Rnh1 Ahnak Ckap4 Ager Hopx Lrrc8c Slc29a2 Smpdl3a Tnfsf11 Pus1 Ptrh2 Anxa4 Fam126b F2rl2 Lclat1 Icos Rhoh Pth1r Emp1 Plec Praf2 Scn9a Nop2 Sh3bgrl2 Cdkn1c Ctla4 Serpinc1 Akap2 Xbp1 Ttc39b Mettl20 Pdcd2l Prnp Ikzf4 Ikzf2 Map6 Bhlhe40 Il1rl1 Penk Galm Map3k8 Arl4a Gadd45b Eno3 Maff Ccr4 Nt5e Eomes Cyfip1 Socs1 Wls Mapkapk2 P4ha1 Il2rb Uck2 Spry4 Socs2 Irf4 Ecm1 Ncoa3 Bcl2l1 Cd79b Gpr65 Fgl2 Lif Rragd Rhob Mxd1 Tnfsf10 Cd86 Amacr Capg Itga6 S100a1 Odc1 Il3ra Traf1 Lrig1 Il18r1 Myc Bcl2 Casp3 Gpx4 Muc1 Slc1a5 Spp1 Fah Ptger2 Bmp2 Gabarapl1 Tnfrsf9 Furin Ahcy P2rx4 Ahr Rgs16 Bmpr2 Syngr2 Nfil3 Tnfrsf8 Coch Col6a1 Tnfrsf4 Il10 Tnfrsf18 Ptch1 Il13 Cd48 Alcam Spred2 Huwe1 Ccnd2 Abcb1a Dhrs3 Hipk2 Cst7 Ppap2a Myo1c Plscr1 Ctsz Gsto1 BIOCARTA_IL2_PATHWAY%MSIGDB_C2%BIOCARTA_IL2_PATHWAY BIOCARTA_IL2_PATHWAY Sos1 Il2rg Jak1 Jak3 Mapk8 Lck Grb2 Shc1 Map2k1 Il2ra Jun Il2 Elk1 Stat5b Stat5a Hras Mapk3 Fos Raf1 Il2rb Syk SA_PROGRAMMED_CELL_DEATH%MSIGDB_C2%SA_PROGRAMMED_CELL_DEATH SA_PROGRAMMED_CELL_DEATH Bcl2l1 Bak1 Bcl10 Apaf1 Casp8ap2 Bcl2 Bax Ces1d Bad Bid Bcl2l11 Casp9 HALLMARK_SPERMATOGENESIS%MSIGDB_C2%HALLMARK_SPERMATOGENESIS HALLMARK_SPERMATOGENESIS Ldhc Dbf4 Zc2hc1c Map7 Mtor Braf Vdac3 Adam2 Taldo1 Nos1 Ccna1 Ybx2 Slc2a5 Rfc4 Hba-x Sirt1 Nek2 Mast2 Il12rb2 Dmrt1 Clvs1 Acrv1 Pgk2 Prm2 Topbp1 Elovl3 Chrm4 Tnni3 Sept4 Stam2 Pomc Tulp2 Znrf4 Adcyap1 Pcsk1n Dcc Pgs1 Mllt10 Odf1 Zpbp Mtnr1a Cct6b Clgn Ezh2 Phf7 Gmcl1 Tuba3b Art3 Dpep3 Dmc1 Ddx25 Ddx4 Gpr182 Phkg2 Nphp1 Zc3h14 Tssk2 Hspa2 Nefh Adad1 Acrbp Papolb Hoxb1 Psmg1 Scg3 Prkar2a Grm8 Tcp11 Strbp Cnih2 Actl7b Htr5a Gfi1 Gsg1 Chfr Camk4 Pias2 Scg5 Mlf1 Oaz3 Rpl39l Tsn Ttk Gstm5 Pcsk4 Pdha2 Tnp1 Kif2c Jam3 Clpb Tnp2 Theg Alox15 Dnajb8 Tekt2 Snap91 Hist1h1t Cdk1 Crisp2 Akap4 Ift88 Npy5r Ip6k1 Sycp1 Naa11 Hspa1l Nf2 Coil Aurka Parp2 Pacrg Hspa4l Spata6 Bub1 Slc12a2 Cftr She Cdkn3 Ccnb2 Csnk2a2 Il13ra2 Rad17 Ide Mep1b Tle4 Lpin1 Cst8 Ace Arl4a Agfg1 Pebp1 Gad1 Tktl1 Gapdhs Ncaph PID_LYMPH_ANGIOGENESIS_PATHWAY%MSIGDB_C2%PID_LYMPH_ANGIOGENESIS_PATHWAY PID_LYMPH_ANGIOGENESIS_PATHWAY Sos1 Creb1 Rps6ka1 Shc1 Mapk14 Vegfc Pik3ca Itgb1 Col1a2 Mapk11 Crk Akt1 Map2k4 Pik3r1 Itga5 Fn1 Grb2 Mapk1 Flt4 Mapk3 Figf Col1a1 Itga4 Itga2 Itga1 BIOCARTA_GPCR_PATHWAY%MSIGDB_C2%BIOCARTA_GPCR_PATHWAY BIOCARTA_GPCR_PATHWAY Adcy1 Prkar2a Prkar2b Creb1 Prkca Gnb1 Map2k1 Nfatc3 Hras Nfatc1 Nfatc2 Plcg1 Prkacb Fos Gnaq Nfatc4 Rps6ka3 Ppp3cc Ppp3ca Ppp3cb Prkar1b Jun Elk1 Prkar1a Prkcb Gngt1 Gnai1 Mapk3 Raf1 PID_IL1_PATHWAY%MSIGDB_C2%PID_IL1_PATHWAY PID_IL1_PATHWAY Irak3 Il1b Il1rap Il1r2 Tab2 Ikbkb Il1a Myd88 Casp1 Ube2n Map3k3 Sqstm1 Map2k6 Pik3ca Prkcz Ticam2 Pik3r1 Irak4 Mapk8 Ube2v1 Prkci Jun Traf6 Ikbkg Il1rn Rela Erc1 Tab1 Nfkb1 Tollip Il1r1 Irak1 Chuk Map3k7 PID_RXR_VDR_PATHWAY%MSIGDB_C2%PID_RXR_VDR_PATHWAY PID_RXR_VDR_PATHWAY Vdr Nr1h3 Thrb Ncor2 Ppard Srebf1 Tnf Nr1h4 Nr4a1 Bcl2 Ncoa1 Rxrg Pparg Rarb Nr1h2 Fam120b Abca1 Rxra Rarg Tgfb1 Thra Rara Rxrb Med1 Ppara PID_IL2_1PATHWAY%MSIGDB_C2%PID_IL2_1PATHWAY PID_IL2_1PATHWAY Sos1 Shc1 Map2k1 Il2ra Il2 Map2k2 Mapk14 Stat5b Stat5a Hras Cish Gab2 Fos Syk Dok2 Mapk11 Mapk8 Stat1 Stat3 Ptpn11 Rhoa Nras Irs1 Mapk1 Mapk3 Raf1 Stam Il2rg Jak1 Prkce Jak3 Ifng Rasa1 Pik3ca Ppp2r5d Cdk2 Myc Irs2 Stam2 Mapk9 Bcl2 Pik3r1 Lck Ikzf3 Kras Fyn Socs3 Grb2 Jun Prkcb Ptk2b Socs1 Mapkapk2 Il2rb Socs2 PID_HNF3B_PATHWAY%MSIGDB_C2%PID_HNF3B_PATHWAY PID_HNF3B_PATHWAY Cpt1a Tat Alb Creb1 Acadvl Igfbp1 Nkx2-1 Acadm Cpt1c Pdx1 Abcc8 Dlk1 Hnf4a Bdh1 Kcnj11 Foxf1 Afp Hnf1b Slc2a2 Cebpb Foxa1 Foxa3 Foxa2 Ins2 Nr3c1 F2 Cebpa Pklr Gck Akt1 Ttr Tfrc Hnf1a G6pc Hadh Aldob Alas1 Sp1 Apoa1 Ucp2 Nf1 Cpt1b Pck1 HALLMARK_APICAL_SURFACE%MSIGDB_C2%HALLMARK_APICAL_SURFACE HALLMARK_APICAL_SURFACE Il2rg Efna5 Adam10 Cx3cl1 Slc2a4 Srpx Lypd3 B4galt1 Ntng1 Adipor2 Gstm5 Gata3 Ephb4 Plaur Dcbld2 Flot2 Shroom2 Sulf2 Gas1 Ncoa6 Atp6v0a4 Hspb1 Mdga1 App Akap7 Rhcg Slc22a12 Slc34a3 Pkhd1 Cd160 Mal Ghrl Atp8b1 Pcsk9 Crocc Rtn4rl1 Afap1l2 Lyn Brca1 Aim1 Scube1 Thy1 Il2rb PID_TCR_JNK_PATHWAY%MSIGDB_C2%PID_TCR_JNK_PATHWAY PID_TCR_JNK_PATHWAY Lcp2 Crkl Crk Map2k4 Lat Mapk8 Jun Map3k8 Map3k1 Prkcb Dbnl Map3k7 Grap2 Map4k1 BIOCARTA_ARENRF2_PATHWAY%MSIGDB_C2%BIOCARTA_ARENRF2_PATHWAY BIOCARTA_ARENRF2_PATHWAY Jun Mapk14 Prkcb Creb1 Maff Mapk1 Mapk8 Fos Mafk Prkca Keap1 Mafg PID_IL12_STAT4_PATHWAY%MSIGDB_C2%PID_IL12_STAT4_PATHWAY PID_IL12_STAT4_PATHWAY Cd4 Crebbp Prf1 Cd80 Pias2 H2-Eb1 Il13 Il2ra Ifng Il2 Cd247 Cd3d Stat4 Etv5 Cd3g Fos Il18r1 Cd3e Il18 Ppp3r1 Irf1 Mapk9 Mapk8 Ppp3ca Stat3 Ppp3cb Jun Tbx21 Il18rap Cd86 Tgfb1 HALLMARK_ANGIOGENESIS%MSIGDB_C2%HALLMARK_ANGIOGENESIS HALLMARK_ANGIOGENESIS Vtn Cxcl5 Nrp1 Kcnj8 Pdgfa Msx1 Apoh Lpl Slco2a1 S100a4 Jag1 Tnfrsf21 Pf4 Ccnd2 Lum Thbd Postn Col5a2 Jag2 Fgfr1 Olr1 App Lrpap1 Prg2 Timp1 Stc1 Col3a1 Ptk2 Pglyrp1 Serpina5 Fstl1 Vegfa Vcan Itgav Spp1 Vav2 PID_S1P_S1P1_PATHWAY%MSIGDB_C2%PID_S1P_S1P1_PATHWAY PID_S1P_S1P1_PATHWAY Gnai2 Pdgfrb S1pr1 Abcc1 Gnai3 Rhoa Sphk1 Gnao1 Gnaz Pdgfb Kdr Itgb3 Plcg1 Gnai1 Vegfa Mapk1 Ptgs2 Itgav Mapk3 Rac1 Plcb2 PID_NCADHERIN_PATHWAY%MSIGDB_C2%PID_NCADHERIN_PATHWAY PID_NCADHERIN_PATHWAY Rock1 Axin1 Dctn1 Kif5b Camk2g Ctnnb1 Ctnnd1 Mapre1 Pip5k1c Cnr1 Gap43 Ptpn1 Lrp5 Plcg1 Pik3ca Daglb Gria2 Dagla Fer Cdh2 Gja1 Gsn Ctnna1 Fgfr1 Pik3r1 Myl2 Mapk8 Ptpn11 Rhoa Cttn Jup Rac1 PID_P73PATHWAY%MSIGDB_C2%PID_P73PATHWAY PID_P73PATHWAY Chek1 Serpina1d Serpina1a Pin1 Hagh Aen Rchy1 Fas Mapk14 Pml Clca2 Brca2 Prkacb Plk1 Casp2 Fasn Flot2 Sfn Cdk1 Rad51 Fbxo45 Dedd Mapk11 Gramd4 Tuba1a Plk3 Itch Jag2 Nedd4l Yap1 Foxo3 Bub1 Bub3 Rela Dcp1b Hsf1 Pfdn5 Wwox Bin1 Pea15a Rnf43 Nsg1 Ube4b Ccna2 Il1rap Jak1 Trp73 Gdf15 Ep300 Il4ra Sirt1 Cdk6 Wt1 Bak1 Afp Gata1 Gnb2l1 Ada Trp63 Rb1 Cdk2 Myc Mdm2 Ccne2 Kat5 Bax Ppap2a Cdkn1a Sp1 Ntrk1 Ndufs2 Bcl2l11 Serpine1 Abl1 Hey2 BIOCARTA_ALK_PATHWAY%MSIGDB_C2%BIOCARTA_ALK_PATHWAY BIOCARTA_ALK_PATHWAY Apc Axin1 Bmp2 Gsk3b Fzd1 Nog Wnt1 Dvl1 Smad5 Smad4 Ctnnb1 Smad1 Rfc1 Bmp10 Gata4 Tgfbr3 Tgfb2 Bmp5 Hnf1a Myl2 Acvr1 Nkx2-5 Nppa Atf2 Chrd Smad6 Tgfb1 Bmpr2 Tgfb3 Map3k7 Bmpr1a Mef2c Bmp4 Tgfbr2 Bmp7 Tgfbr1 BIOCARTA_TOB1_PATHWAY%MSIGDB_C2%BIOCARTA_TOB1_PATHWAY BIOCARTA_TOB1_PATHWAY Tgfbr3 Tgfb2 Smad3 Il4 Il2ra Ifng Il2 Smad4 Cd247 Cd3d Tob1 Tgfb1 Tob2 Tgfb3 Cd3g Cd3e Tgfbr2 Tgfbr1 PID_AMB2_NEUTROPHILS_PATHWAY%MSIGDB_C2%PID_AMB2_NEUTROPHILS_PATHWAY PID_AMB2_NEUTROPHILS_PATHWAY Icam1 Rock1 Il6 Selp Selplg Ager Yes1 Src Apob Jam3 Mmp2 Plaur Plat Blk Itgam Prkcz Itgb2 Tnf Plg Tln1 Myh2 Mst1 Akt1 Jam2 Hck Lck Rap1b Rap1a Fyn Rhoa Plau Mmp9 Fgr Lrp1 Mst1r Nfkb1 Lyn Ctgf Thy1 BIOCARTA_GCR_PATHWAY%MSIGDB_C2%BIOCARTA_GCR_PATHWAY BIOCARTA_GCR_PATHWAY Nos3 Akt1 Pik3r1 Nppa Gnb1 Pik3cg Adrb2 Gngt1 Hsp90aa1 Corin Rela Nfkb1 Pik3ca Anxa1 Nr3c1 PID_FOXO_PATHWAY%MSIGDB_C2%PID_FOXO_PATHWAY PID_FOXO_PATHWAY Kat2b Ikbkb Crebbp Ywhaz Ep300 Foxo4 Skp2 Usp7 Sirt1 Ctnnb1 Fasl Csnk1a1 Plk1 Cdk2 Csnk1e Sfn Rbl2 Foxo1 Csnk1d Mapk10 Csnk1g2 Gadd45a Mapk9 Mst1 Csnk1g3 Akt1 Csnk1g1 Sod2 Cat Ralb G6pc Mapk8 Ywhae Foxo3 Rala Xpo1 Zfand5 Fbxo32 Ywhab Sgk1 Bcl6 Cdkn1b Ran Chuk Ywhah Bcl2l11 Ywhag PID_ATR_PATHWAY%MSIGDB_C2%PID_ATR_PATHWAY PID_ATR_PATHWAY Chek1 Ccna2 Tipin Cdc25c Mcm7 Cep164 Clspn Ppp2r2b Sspo Cdc25a Ywhaz Rpa1 Smarcal1 Timeless Rad1 Fancd2 Brca2 Rad17 Trex1 Plk1 Rad9a Cdk2 Atrip Hus1 Topbp1 Cdc6 Rad51 Mdm2 Rpa2 Mcm2 Fbxw11 Ywhab Ppp2ca Nbn Ppp2r1a Rfc5 Rfc3 Rfc4 Rfc2 PID_MYC_ACTIV_PATHWAY%MSIGDB_C2%PID_MYC_ACTIV_PATHWAY PID_MYC_ACTIV_PATHWAY Ldha Eif4a1 Ddx18 Cad Id2 Smad4 Pim1 Tert Rcc1 Birc5 Rpl11 Trp53 Mta1 Gpam Nme1 Tfrc Eif4e Smad3 Nbn Hsp90aa1 Serpini1 Slc2a1 Crebbp Cdc25a Odc1 Ep300 Tk1 Eno1b Ruvbl1 Fosl1 Snai1 Bcat1 Hspd1 Myc Kat2a Ccnd2 Huwe1 Bmi1 Shmt1 Taf4b E2f3 Mina Nme2 Actl6a Eif4g1 Ireb2 Kat5 Lin28b Taf9 Pfkm Peg10 Bax Cdk4 Taf12 Ruvbl2 Eif2s1 Pdcd10 Ak6 Myct1 Prdx3 Supt7l Npm1 Eno1 Hmga1 Trrap Mmp9 Ubtf Polr3d Ndufaf2 Mtdh Hspa4 Max Supt3 PID_FGF_PATHWAY%MSIGDB_C2%PID_FGF_PATHWAY PID_FGF_PATHWAY Sos1 Pak4 Camk2a Hgf Ncam1 Runx2 Spry2 Rps6ka1 Shc1 Pdpk1 Stat5b Fgfr4 Fgf18 Il17rd Fgfr2 Fos Klb Fgf17 Fgf15 Cdh2 Sdc2 Akt1 Fgf2 Frs2 Stat1 Fgf23 Ptpn11 Ssh1 Mapk1 Mapk3 Cttn Met Ctnnd1 Src Cdh1 Plcg1 Fgf1 Plaur Pik3ca Fgf6 Fgf8 Fgf9 Gab1 Fgfr1 Pik3r1 Grb2 Jun Plau Ptk2b Mmp9 Cbl Spp1 Fgf4 Fgfr3 BIOCARTA_AKAPCENTROSOME_PATHWAY%MSIGDB_C2%BIOCARTA_AKAPCENTROSOME_PATHWAY BIOCARTA_AKAPCENTROSOME_PATHWAY Akap9 Nup85 Pcnt Prkar2a Prkce Prkar2b Prkag1 Pkn1 Rhoa Ppp2ca Ppp1ca Prkacb Cdk1 HALLMARK_KRAS_SIGNALING_UP%MSIGDB_C2%HALLMARK_KRAS_SIGNALING_UP HALLMARK_KRAS_SIGNALING_UP Csf2 Car2 Akap12 Gypc Il10ra Gucy1a3 Map7 Irf8 Csf2ra Aldh1a3 Slpi Angptl4 Ank Adam8 Tnfrsf1b Reln Cmklr1 Serpina3n Psmb8 Cxcl10 Ets1 Birc3 Ephb2 Bpgm Pcsk1n G0s2 Etv1 Plau Mmp9 Ptgs2 Scg3 Pecam1 Ereg Scg5 Snap91 Itgb2 Wnt7a Ly96 Prkg2 Flt4 Jup Ccl20 Il1b Il2rg Nrp1 Rabgap1l Etv4 Retn Fgf9 Emp1 Mpzl2 Nr1h4 Nr0b2 Ero1l Ace Gadd45g Tfpi Hoxd11 Adgra2 Laptm5 Ptcd2 Nap1l2 Kif5c Tspan1 Ptbp2 Tspan7 Lat2 Nin Btbd3 Spry2 Fbxo4 Anxa10 Slmo2 Ptprr Fuca1 Mafb Gabra3 Peg3 Gpnmb Gfpt2 Avl9 Ush1c Hdac9 Trib1 Adam17 Trib2 Hkdc1 Galnt3 Tlr8 Cbx8 Rbm4 Cxcr4 Kcnn4 Zfp277 Dnmbp Mycn Il33 Eng Cd37 Lif Usp12 Tmem100 Plvap Yrdc Gng11 Epb4.1l3 Prrx1 Mtmr10 Atg10 Clec4a2 Prdm1 Ikzf1 Fcer1g Il1rl2 Tmem176a Strn Ccser2 Lcp1 Tmem158 Cfhr2 Plek2 Pdcd1lg2 Sdccag8 Ppp1r15a Snap25 Itga2 Mall Gprc5b Dock2 Tspan13 Pcp4 Btc Tnfaip3 Traf1 Arg1 Rbp4 Wdr33 Ammecr1 Cbr4 Etv5 Zfp639 Hbegf Tph1 Ctss Hsd11b1 Vwa5a F2rl1 Map3k1 Inhba Sparcl1 Mmp10 Igf2 Ppbp Spp1 Mmp11 Cbl Glrx Bmp2 Cfh Id2 Plat Adamdec1 Cfb Cidea Satb1 Akt2 Rgs16 Il7r Cpe Tnnt2 Scn1b Tmem176b F13a1 Igfbp3 Plaur C3ar1 Dcbld2 Map4k1 Crot Ccnd2 Abcb1a Spon1 Hist3h2ba Mmd Adgrl4 Tor1aip2 St6gal1 Cab39l Apod Pigr Sox9 Aldh1a2 Cdadc1 Dusp6 Ano1 Itgbl1 Sema3b Klf4 Evi5 Ngf BIOCARTA_NDKDYNAMIN_PATHWAY%MSIGDB_C2%BIOCARTA_NDKDYNAMIN_PATHWAY BIOCARTA_NDKDYNAMIN_PATHWAY Ap2m1 Nme2 Nme1 Ap2a1 Amph Dnm1 Ppp3cc Ppp3ca Eps15 Epn1 Ppp3cb Synj1 Bin1 Synj2 Picalm HALLMARK_UV_RESPONSE_UP%MSIGDB_C2%HALLMARK_UV_RESPONSE_UP HALLMARK_UV_RESPONSE_UP Car2 Msx1 Cebpg Col2a1 Atf3 Prkaca Hmox1 Fos Btg1 Grpel1 Tgfbrap1 Ntrk3 Igfbp2 Rhob Shox2 Dgat1 Rasgrp1 Rfc4 Rxrb Il6st Ccnd3 Cxcl1 Tmbim6 Tchh Arrb2 Asns Stk25 Ppif Bak1 Btg2 Urod E2f5 Sqstm1 Btg3 Cdk2 Irf1 Olfm1 Fmo1 Maoa Tap1 Tars Slc6a8 Cnp Ccne1 Bid Casp3 Ret Gpx3 Ctsl Bsg Lyn Hspa2 Mmp14 Cltb Polg2 Icam1 Spr Wiz Bmp2 Mgat1 Stard3 Stip1 Chrna5 Slc6a12 Rpn1 Epcam Ago2 Lhx2 Onecut1 Cck Fen1 Cdc5l Atp6v1f Nupl1 Cyb5b Sepw1 Cyp1a1 Pdap1 Junb Nptx2 Tyro3 Gls Hnrnpu Hyal2 Eif2s3x Furin Eif5 Fosb Grina Fgf18 Polr2h Clcn2 Ppat H2-M5 Dnajb1 Dlg4 Slc25a4 H2afx Nr4a1 Tfrc Tacr3 Parp2 Gal Klhdc3 Psmc3 Mark2 Cyb5r1 Sigmar1 Nfkbia Htr7 Nat2 Creg1 Prpf3 Mapk8ip2 Apom Hspa13 Ykt6 Ppt1 Gch1 Tuba4a Ap2s1 Nxf1 Il6 Kcnh2 Acaa1a Rrad Aqp3 Prkcd Pole3 Chka Abcb1a Fkbp4 Ddx21 Sult1a1 Atp6v1c1 Dnaja1 Cdkn1c Nptxr Sod2 Cdkn2b Aldoa Nkx2-5 Eno2 Alas1 Tst Ephx1 Cdc34 Rab27a Bcl2l11 Cdo1 ST_PAC1_RECEPTOR_PATHWAY%MSIGDB_C2%ST_PAC1_RECEPTOR_PATHWAY ST_PAC1_RECEPTOR_PATHWAY Gnaq Asah1 Dag1 Itpkb Gast Itpka Camp BIOCARTA_EXTRINSIC_PATHWAY%MSIGDB_C2%BIOCARTA_EXTRINSIC_PATHWAY BIOCARTA_EXTRINSIC_PATHWAY Tfpi F2 F2r F10 Pros1 Serpinc1 F3 F5 F7 Proc Fga Fgb Fgg PID_INTEGRIN_CS_PATHWAY%MSIGDB_C2%PID_INTEGRIN_CS_PATHWAY PID_INTEGRIN_CS_PATHWAY Itgal Itga3 Itgb5 Itgax Itgb3 Itgad Itgb4 Itgb1 Itgam Itgb2 Itga2b Itgb6 Itgb7 Itga5 Itgae Itgb8 Itga11 Itga10 Itga8 Itga9 Itga6 Itga7 Itgav Itga4 Itga2 Itga1 BIOCARTA_SPRY_PATHWAY%MSIGDB_C2%BIOCARTA_SPRY_PATHWAY BIOCARTA_SPRY_PATHWAY Sos1 Spry3 Spry2 Spry1 Ptprb Grb2 Shc1 Map2k1 Rasa1 Egfr Hras Src Egf Mapk1 Mapk3 Cbl Raf1 Spry4 PID_SHP2_PATHWAY%MSIGDB_C2%PID_SHP2_PATHWAY PID_SHP2_PATHWAY Sos1 Pdgfrb Lmo4 Arhgap35 Shc1 Map2k1 Il2ra Il2 Map2k2 Hras Egf Gab2 Bdnf Prkaca Angpt1 Jak2 Sdc2 Nos3 Ntf3 Ntrk3 Frs3 Frs2 Stat1 Tek Gnai3 Ptpn11 Rhoa Mllt4 Pag1 Kdr Ntrk2 Nras Irs1 Vegfa Raf1 Il6st Il2rg Igf1r Il6 Jak1 Jak3 Igf1 Ifng Ifngr1 Pik3ca Gab1 Ntf5 Pik3r1 Lck Kras Grb2 Egfr Pdgfb Il6ra Ntrk1 Gnai1 Ngf Il2rb HALLMARK_PANCREAS_BETA_CELLS%MSIGDB_C2%HALLMARK_PANCREAS_BETA_CELLS HALLMARK_PANCREAS_BETA_CELLS Sst Insm1 Pak3 Chga Elp4 Isl1 Srp14 G6pc2 Neurog3 Vdr Neurod1 Pax4 Pcsk1 Pdx1 Sec11a Abcc8 Iapp Pcsk2 Mafb Slc2a2 Lmo2 Foxa2 Gcg Ins2 Foxo1 Dpp4 Akt3 Pklr Gck Hnf1a Srprb Dcx Spcs1 Srp9 Scgn Stxbp1 Syt13 Pax6 Nkx6-1 Nkx2-2 BIOCARTA_IGF1MTOR_PATHWAY%MSIGDB_C2%BIOCARTA_IGF1MTOR_PATHWAY BIOCARTA_IGF1MTOR_PATHWAY Igf1r Igf1 Gsk3b Akt1 Pdk2 Pik3r1 Eif2b5 Eif4e Eif2s1 Eif2s2 Pten Pdpk1 Ppp2ca Mtor Eif2s3x Pik3ca Eif4ebp1 Inppl1 BIOCARTA_ERK5_PATHWAY%MSIGDB_C2%BIOCARTA_ERK5_PATHWAY BIOCARTA_ERK5_PATHWAY Mapk7 Akt1 Creb1 Pik3r1 Mef2d Rps6ka1 Grb2 Shc1 Pik3cg Hras Plcg1 Ntrk1 Pik3ca Mapk1 Mapk3 Mef2c Mef2a PID_AP1_PATHWAY%MSIGDB_C2%PID_AP1_PATHWAY PID_AP1_PATHWAY Cops5 Bag1 Csf2 Cbfb Acta1 Creb1 Tcf7l2 Dmp1 Il2 Junb Egr1 Mmp1a Trp53 Atf3 Fosb Jund Fos Dmtf1 Cdk1 Ccl12 Gja1 Elf1 Dusp1 Hif1a Pten Gata2 Tgfb1 Cdkn1b Il6 Fabp4 Cdkn2a Ets1 Ep300 Il5 Il10 Il4 Ifng Fosl2 Th Ctnnb1 Nfatc3 Nfatc1 Fosl1 Crtc1 Trip6 Myb Nfatc2 Nts Ccnd1 Myc Nr3c1 Col1a2 Cyr61 Penk Nppa Timp1 Atf2 Jun Agt Plau Mt2 Sp1 Mmp9 H2-Q10 Edn1 Esr1 Mafg Bcl2l11 Maf BIOCARTA_MTOR_PATHWAY%MSIGDB_C2%BIOCARTA_MTOR_PATHWAY BIOCARTA_MTOR_PATHWAY Pdk2 Eif4a1 Eif4g2 Akt1 Eif4g1 Tsc2 Pik3r1 Eif4b Tsc1 Eif4e Eif4a2 Mknk1 Pten Pdpk1 Eif4g3 Ppp2ca Mtor Pik3ca Eif4ebp1 Fkbp1a Eif3a PID_ERBB4_PATHWAY%MSIGDB_C2%PID_ERBB4_PATHWAY PID_ERBB4_PATHWAY Nrg3 Nrg1 Nrg4 Tab2 Erbb4 Ereg Ncor1 Prl Btc Shc1 Grin2b Stat5b Stat5a Prlr Lrig1 Adam17 Pik3ca Jak2 Hbegf Dlg4 Mdm2 Wwp1 Itch Pik3r3 Pik3r1 Pik3r2 Yap1 Pik3cb Fyn Cbfa2t3 Grb2 Pik3cd Nedd4 Nrg2 Erbb2 Mapk1 Mapk3 Wwox BIOCARTA_EGF_PATHWAY%MSIGDB_C2%BIOCARTA_EGF_PATHWAY BIOCARTA_EGF_PATHWAY Sos1 Jak1 Stat2 Stat6 Prkca Map2k1 Shc1 Rasa1 Stat5b Hras Stat5a Stat4 Egf Srf Plcg1 Pik3ca Fos Map2k4 Pik3r1 Mapk8 Stat1 Stat3 Grb2 Jun Elk1 Egfr Prkcb Map3k1 Mapk3 Raf1 PID_FOXM1_PATHWAY%MSIGDB_C2%PID_FOXM1_PATHWAY PID_FOXM1_PATHWAY Ccna2 Cenpa Crebbp Cenpf Cdkn2a Cdc25b Lama4 Gsk3a Ep300 Onecut1 Skp2 Tgfa Map2k1 Nek2 Xrcc1 Brca2 Birc5 Nfatc3 Rb1 Plk1 Mmp2 Etv5 Ccnd1 Cdk2 Cenpb Fos Foxm1 Myc Cdk1 Aurkb Gas1 Chek2 Ccne1 Cdk4 Cks1b Sp1 Esr1 Ccnb2 PID_BARD1_PATHWAY%MSIGDB_C2%PID_BARD1_PATHWAY PID_BARD1_PATHWAY Mre11a Atm Pcna Ewsr1 Rad50 Fancd2 Ube2l3 Fancc Trp53 Cstf1 Cdk2 Topbp1 Fancl Rad51 Prkdc Ccne1 Npm1 Xrcc5 Rbbp8 Nbn Xrcc6 Brca1 Ube2d3 Fanca Bard1 Fancg Fancf PID_AVB3_INTEGRIN_PATHWAY%MSIGDB_C2%PID_AVB3_INTEGRIN_PATHWAY PID_AVB3_INTEGRIN_PATHWAY Vtn Col13a1 Adgra2 Col14a1 Col17a1 Col2a1 Col4a4 Col4a3 F11r Col4a1 Col16a1 Pxn Bcar1 Ilk Col11a1 Akt1 Fgf2 Col11a2 Col12a1 Pik3c2a Pi4kb Ptpn11 Rhoa Pi4ka Fn1 Vcl Col6a3 Col6a2 Kdr Hsp90aa1 Col3a1 Casp8 Cdkn1b Irs1 Mapk1 Vegfa Mapk3 Angptl3 Tgfbr2 Rac1 Rock1 Igf1r Col7a1 Igf1 Sdc1 Col5a1 Col6a1 Csf1 Col10a1 Src Itgb3 Col15a1 Col8a2 Pik3ca Col1a2 Col9a1 Tln1 Col9a2 Col5a2 Col8a1 Col9a3 Pik3r1 Col4a5 Col4a6 Csf1r Vav3 Mfge8 Ptk2b Ptk2 Col1a1 Itgav Edil3 Cbl Spp1 BIOCARTA_CARM1_PATHWAY%MSIGDB_C2%BIOCARTA_CARM1_PATHWAY BIOCARTA_CARM1_PATHWAY Prkar1b Prkar1a Prkar2a Crebbp Prkar2b Rxra Creb1 Prkacb Carm1 Ep300 Ncoa3 Rara HALLMARK_TNFA_SIGNALING_VIA_NFKB%MSIGDB_C2%HALLMARK_TNFA_SIGNALING_VIA_NFKB HALLMARK_TNFA_SIGNALING_VIA_NFKB Gem Klf6 Csf2 Slc16a6 Tnip1 Kdm6b Fjx1 Phlda2 Nfe2l2 Ppap2b Cd80 Ackr3 Birc2 Plk2 B4galt1 Klf9 Pnrc1 Ifih1 Dram1 Per1 Fut4 Stat5a Ccnl1 Trip10 Egr1 Slc2a6 Klf2 Panx1 Rnf19b Tgif1 Ier2 Tiparp Atf3 Ehd1 Snn Spsb1 Sat1 Dnajb4 Fos B4galt5 Ier5 Eif1 Ccl12 Btg1 Pde4b Sdc4 Zfp36 Tnfaip2 Tubb2a Serpinb8 Slc2a3 Il6st Nr4a2 Il15ra Cxcl11 Hes1 Cxcl10 Serpinb2 Cd44 Csf1 Ets2 Tlr2 Birc3 Btg2 Cxcl3 Ifngr2 Cxcl2 Ccrl2 Irf1 Mcl1 G0s2 Zc3h12a Sik1 Msc Litaf Cdkn1a Plau Atp2b1 Edn1 Ptgs2 Serpine1 Ifit2 Icam1 Bcl2a1d Il1a Junb Rcan1 Egr2 Fosb Egr3 Tnf Dusp1 Smad3 Bcl3 Sphk1 Dennd5a Rela Vegfa Ptx3 Ccl20 Cd83 Il1b Il6 Tank F3 Phlda1 Fosl2 Ddx58 Cd69 Fosl1 Nampt Efna1 Pfkfb3 Ier3 Gadd45a Areg Bhlhe40 Jun Relb Map3k8 Gadd45b Ripk2 Ccl4 Bcl6 Maff Dusp5 Marcks Cebpb Gfpt2 Trib1 Tnc Tnfaip6 Lif Yrdc Rhob Mxd1 Clcf1 Cflar Abca1 Sgk1 Ppp1r15a Cxcl5 Cxcl1 Dusp2 Il12b Tnfaip3 Traf1 Sqstm1 Btg3 Klf10 Ccnd1 Hbegf Myc Il18 Irs2 Tap1 Il23a Icosl Map2k3 Olr1 Nr4a3 Ccl5 F2rl1 Socs3 Inhba Lamb3 Bmp2 Ptger4 Tnfrsf9 Plek Id2 Kynu Pdlim5 Rel Ninj1 Nr4a1 Tnip2 Nfkb2 Gpr183 Nfkbie Nfkbia Il7r Nfkb1 Gch1 Nfil3 Jag1 Plaur Cyr61 Sod2 Dusp4 Pmepa1 Klf4 Tsc22d1 Zbtb10 Tnfaip8 Ptpre Ldlr Nfat5 PID_PS1_PATHWAY%MSIGDB_C2%PID_PS1_PATHWAY PID_PS1_PATHWAY Apc Axin1 Sspo Gsk3b Crebbp Adam10 Fzd1 Wnt1 Dvl1 Dtx1 Ctnnb1 Ctbp1 Notch1 Psen1 Csnk1a1 Ppard Ppp2r5d Rbpj Ccnd1 Lrp6 Dll1 Fos Myc Nkd1 Aph1b Hdac1 Dkk2 Tle1 Hnf1a Kremen2 Ncstn Fbxw11 Jun Dkk1 Nedd4 Nlk Aes Tab1 Mapk1 Mapk3 Map3k7 Wif1 PID_INTEGRIN4_PATHWAY%MSIGDB_C2%PID_INTEGRIN4_PATHWAY PID_INTEGRIN4_PATHWAY Lamc2 Lamc1 Lama1 Lama3 Lamb3 Itgb4 Itga6 Lamb1 Lama2 Lama5 Lamb2 BIOCARTA_THELPER_PATHWAY%MSIGDB_C2%BIOCARTA_THELPER_PATHWAY BIOCARTA_THELPER_PATHWAY Icam1 Cd4 Cd247 Itgal Cd3d Cd2 Ptprc Cd3g Cd3e Thy1 Itgb2 ST_WNT_CA2_CYCLIC_GMP_PATHWAY%MSIGDB_C2%ST_WNT_CA2_CYCLIC_GMP_PATHWAY ST_WNT_CA2_CYCLIC_GMP_PATHWAY Cfb Pde6a Pde6g Camk2a Trf Pde6h Camk2b Camk2d Camk2g Itpr3 Pde6b Pde6d Dag1 Pde6c Itpkb Slc6a13 Itpr1 Itpka Itpr2 Nfat5 PID_HDAC_CLASSIII_PATHWAY%MSIGDB_C2%PID_HDAC_CLASSIII_PATHWAY PID_HDAC_CLASSIII_PATHWAY Kat2b Crebbp Myod1 Ep300 Mef2d Foxo4 Sirt1 Hdac4 Trp53 Fhl2 Foxo1 Bax Acss2 Foxo3 Tubb2a Cdkn1a Acss1 Sirt2 Ppargc1a Xrcc6 Tuba1b Hoxa10 Hist1h1e Sirt3 Sirt7 PID_INTEGRIN3_PATHWAY%MSIGDB_C2%PID_INTEGRIN3_PATHWAY PID_INTEGRIN3_PATHWAY Vtn Ibsp Sdc1 Pdgfrb Pecam1 Lama4 Col4a4 Lamc1 Col4a3 Itgb3 F11r Fbn1 Col4a1 Plaur L1cam Fga Fgb Tnc Fgg Col1a2 Itga2b Cyr61 Sdc4 Col4a5 Col4a6 Fn1 Sphk1 Thbs1 Plau Pdgfb Kdr Cd47 Vegfa Col1a1 Lamb1 Itgav Edil3 Spp1 Thy1 Tgfbi Tgfbr2 HALLMARK_PI3K_AKT_MTOR_SIGNALING%MSIGDB_C2%HALLMARK_PI3K_AKT_MTOR_SIGNALING HALLMARK_PI3K_AKT_MTOR_SIGNALING Gsk3b Tsc2 Akt1s1 Sla Rps6ka1 Ube2n Rit1 Hras Rptor Sfn Cxcr4 Tnfrsf1a Ralb Eif4e Ptpn11 Pfn1 Pten Ywhab Ripk1 Smad2 Mapkap1 Ppp1ca Nod1 Mapk1 Ube2d3 Raf1 Rac1 Slc2a1 Stat2 Tbk1 Adcy2 Pikfyve Ppp2r1b Pla2g12a Cab39 Myd88 Them4 Sqstm1 Map2k6 Cdk2 Fgf22 Ap2m1 Arf1 Map2k3 Arhgdia Ecsit Cdkn1a Dusp3 Egfr Prkcb Gngt1 Gna14 Calr Map3k7 Plcb1 Pak4 Prkar2a Pin1 Prkag1 Camk4 Dapp1 Prkaa2 Fasl Fgf17 Cdk1 Csnk2b Tiam1 Akt1 Pdk1 Mapk8 Irak4 Traf2 Adrbk1 Nfkbib Acaca Pitx2 Cdkn1b Arpc3 Actr3 Actr2 Itpr2 Il2rg Mknk2 Mknk1 Il4 Plcg1 Cltc Fgf6 Mapk10 Mapk9 Pik3r3 Nck1 Cab39l Rps6ka3 Cdk4 Lck E2f1 Grb2 Vav3 Ddit3 Hsp90b1 Trib3 Ngf BIOCARTA_RAS_PATHWAY%MSIGDB_C2%BIOCARTA_RAS_PATHWAY BIOCARTA_RAS_PATHWAY Akt1 Ralgds Pik3r1 Foxo4 Rala Rhoa Casp9 Bcl2l1 Map2k1 Pik3cg Elk1 Hras Ralbp1 Rela Nfkb1 Pik3ca Mapk3 Pld1 Bad Chuk Raf1 Rac1 PID_CDC42_PATHWAY%MSIGDB_C2%PID_CDC42_PATHWAY PID_CDC42_PATHWAY Apc Pak4 Gsk3b Eps8 Mapk14 Hras Mtor Exoc7 Braf Bcar1 Iqgap1 Tiam1 Ctnna1 Dlg1 Rasgrf1 Mapk8 Tnk2 Arpc5 Mapk1 Arpc2 Mapk3 Arpc3 Arpc4 Pld1 Actr3 Actr2 Raf1 Arpc1b Vav2 Rac1 Hes5 Sept2 Diap3 Prkce Pak1 Ctnnb1 Yes1 Src Cdh1 Map2k6 Pik3ca F2rl2 Prkcz Cdc42bpa Map2k7 Wasl Baiap2 Pard6a Mapk9 Map3k11 Iqgap3 Map2k4 Map2k3 Pik3r1 Myl2 Pak2 Limk1 Limk2 Arhgdia Atf2 Jun Arhgef6 Map3k1 Arhgef7 Pax6 Cbl BIOCARTA_CALCINEURIN_PATHWAY%MSIGDB_C2%BIOCARTA_CALCINEURIN_PATHWAY BIOCARTA_CALCINEURIN_PATHWAY Gnaq Nfatc4 Prkca Ppp3cc Ppp3ca Ppp3cb Cdkn1a Marcks Sp1 Nfatc3 Prkcb Nfatc1 Nfatc2 Sp3 Plcg1 HALLMARK_DNA_REPAIR%MSIGDB_C2%HALLMARK_DNA_REPAIR HALLMARK_DNA_REPAIR Cetn2 Eif1b Tsg101 Sec61a1 Pold3 Pold4 Brf2 Pold1 Gm21987 Polr2i Nelfb Polr2d Polr2c Ssrp1 Nfx1 Mpg Nelfe Aaas Ncbp2 Pcna Taf1c Pola2 Smad5 Polr2f Polr2g Rad52 Polr2e Gtf2b Zwint Polr2j Polr2k Supt4a Vps37b Rrm2b Aprt Taf6 Arl6ip1 Rnmt Ell Rad51 Pom121 Pde4b Dctn4 Itpa Gtf2a2 Vps37d Clp1 Cant1 Rpa2 Ddb1 Stx3 Ddb2 Pole4 Bcap31 Snapc4 Alyref Dfna5 Rala Snapc5 Srsf6 Nudt9 Gmpr2 Gtf2h1 Gtf3c5 Gtf2h5 Upf3b Ago4 Edf1 Tk2 Pnp Mrpl40 Rfc5 Nme3 Rfc3 Nme4 Rfc4 Sac3d1 Rfc2 Supt5 Gtf2h3 Xpc Dgcr8 Hprt Ada Cmpk2 Pde6g Poll Taf9 Hcls1 Taf12 Ak6 Gpx4 Pola1 Ercc2 Znrd1 Nelfcd Tyms Cox17 Polr3c Nt5c Cda Sdcbp Usp11 Rbx1 Fen1 Trp53 Polr2h Bcam Tonsl Nme1 Polr2a Dut Umps Bola2 Polr1c Polr1d Cstf3 Ccno Adrm1 Npr2 Nt5c3 Polh Nudt21 Zfp707 Tarbp2 Dad1 Polb Dguok Surf1 Rev3l Ercc8 Ercc5 Ercc4 Guk1 Ak1 Taf13 Prim1 Tceb3 Polr3gl Ak3 Mpc2 Lig1 Sf3a3 Rpa3 Rae1 Ercc3 Ercc1 Gtf2f1 Adcy6 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY%MSIGDB_C2%ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY Sos1 Gsk3b Ppp1r13b Cdkn2a Ywhaz Igfbp1 Gsk3a Iars Cyth3 Dapp1 Rps6ka1 Shc1 Pik3ca Exosc1 Bad Sfn Foxo1 Akt3 Btk Akt1 Pdk1 Rps6ka3 Nr4a3 Inpp5d Ywhae Akt2 Grb2 Pten Ywhab Rps6ka2 A1bg Ywhah Ywhag Sos2 BIOCARTA_VEGF_PATHWAY%MSIGDB_C2%BIOCARTA_VEGF_PATHWAY BIOCARTA_VEGF_PATHWAY Eif2b5 Prkca Eif2s2 Shc1 Hras Eif2s3x Plcg1 Pik3ca Pxn Arnt Eif1 Nos3 Vhl Hif1a Pik3r1 Eif2s1 Eif2b4 Eif2b2 Eif2b3 Eif2b1 Pik3cg Elavl1 Prkcb Kdr Ptk2 Eif1ax Vegfa Flt4 Flt1 BIOCARTA_TPO_PATHWAY%MSIGDB_C2%BIOCARTA_TPO_PATHWAY BIOCARTA_TPO_PATHWAY Sos1 Pik3r1 Mpl Stat1 Prkca Stat3 Grb2 Shc1 Map2k1 Jun Pik3cg Rasa1 Stat5b Prkcb Stat5a Hras Plcg1 Pik3ca Mapk3 Fos Jak2 Raf1 Thpo BIOCARTA_CDC42RAC_PATHWAY%MSIGDB_C2%BIOCARTA_CDC42RAC_PATHWAY BIOCARTA_CDC42RAC_PATHWAY Wasl Pik3r1 Pak1 Pdgfra Rhoa Arpc5 Arpc1a Pik3ca Arpc2 Arpc3 Arpc4 Actr3 Actr2 Rac1 Arpc1b BIOCARTA_MTA3_PATHWAY%MSIGDB_C2%BIOCARTA_MTA3_PATHWAY BIOCARTA_MTA3_PATHWAY Hdac1 Tuba1a Tuba1c Pdzk1 Mbd3 Hspb1 Mta3 Aldoa Hspb2 Tuba3b Ctsd Cdh1 Snai1 Esr1 Snai2 Mta1 Tuba4a BIOCARTA_ARF_PATHWAY%MSIGDB_C2%BIOCARTA_ARF_PATHWAY BIOCARTA_ARF_PATHWAY Tbx2 Mdm2 Polr1c Polr1d Polr1b Polr1a Cdkn2a Pik3r1 E2f1 Twist1 Pik3cg Rb1 Trp53 Pik3ca Myc Abl1 Rac1 BIOCARTA_EIF_PATHWAY%MSIGDB_C2%BIOCARTA_EIF_PATHWAY BIOCARTA_EIF_PATHWAY Eef2k Eif4a1 Eif4g2 Eif4g1 Eif4e Eif2s1 Eif2s2 Eif4a2 Eef2 Eif4g3 Eif2s3x Eif5 Eif1ax Eif6 Eif1 Eif3a PID_PI3KCI_AKT_PATHWAY%MSIGDB_C2%PID_PI3KCI_AKT_PATHWAY PID_PI3KCI_AKT_PATHWAY Gsk3b Ywhaz Gsk3a Slc2a4 Foxo4 Mlst8 Bcl2l1 Pdpk1 Src Mtor Map3k5 Prkaca Bad Sfn Foxo1 Rictor Kpna1 Akt3 Akt1 Prkdc Ywhae Foxo3 Akt2 Casp9 Cdkn1a Ywhab Hsp90aa1 Mapkap1 Cdkn1b Tbc1d4 Ywhah Chuk Ywhag Raf1 PID_P53_DOWNSTREAM_PATHWAY%MSIGDB_C2%PID_P53_DOWNSTREAM_PATHWAY PID_P53_DOWNSTREAM_PATHWAY Apc Pou4f1 Tsc2 Serpinb5 Pou4f2 Pcna Dusp5 Tfdp1 Bcl2l1 Pml Cd82 Ctsd Ddit4 Atf3 Col18a1 Rrm2b Nfya Sfn Nfyb Plk3 Ddx5 Lif Ddb2 Ndrg1 Prdm1 Pten Tnfrsf10b Dgcr8 Trp73 Crebbp Apaf1 Cx3cl1 Gdf15 Ep300 Map4k4 Tgfa Hic1 Bak1 Btg2 Rb1 Kat2a Tap1 Mcl1 Taf9 Bcl2 Bax Bid Casp6 Ak6 Cdkn1a Egfr Sp1 Trrap Edn2 Spp1 Serpine1 Smarca4 Prkab1 Bcl2a1d Hdac2 Ppp1r13b Hgf Casp1 Rchy1 Fas Ccng1 Foxa1 Trp53 Mmp2 Gpx1 Cse1l Bdkrb2 Dusp1 Msh2 Pidd1 Bnip3l Cav1 Jmy Arid3a Htt Tigar Vdr Prmt1 Perp Met Bcl2l14 Afp Igfbp3 Bcl2l2 Triap1 Scn3b Steap3 Epha2 Tyrp1 Rnf144b Trp63 Drosha Irf5 Rps27l Pcbp4 Aifm2 Nlrc4 Trp53bp2 Ccnk Ppm1j Zfp385a Sesn1 Mdm2 E2f3 Gadd45a Rsph10b Pms2 Pycard Carm1 Sh2d1a E2f2 Rgcc Mlh1 Cebpz E2f1 Rfwd2 Nfyc Trp53inp1 Jun Dkk1 Bcl6 Fdxr Vcan Snai2 BIOCARTA_RAC1_PATHWAY%MSIGDB_C2%BIOCARTA_RAC1_PATHWAY BIOCARTA_RAC1_PATHWAY Cdk5 Cdk5r1 Trio Pik3r1 Myl2 Pdgfra Pak1 Mylk Vav1 Limk1 Ncf2 Ppp1r12b Wasf1 Pik3cg Map3k1 Ralbp1 Pik3ca Arfip2 Pld1 Rac1 NABA_ECM_GLYCOPROTEINS%MSIGDB_C2%NABA_ECM_GLYCOPROTEINS NABA_ECM_GLYCOPROTEINS Ibsp Zp3 Zp2 Sspo Ecm1 Vwa3a Tinag Oit3 Rspo2 Rspo1 Lamc3 Srpx Ecm2 Creld1 Creld2 Wisp2 Pcolce Rspo3 Lamc2 Igfbp6 Rspo4 Lamc1 Tsku Fgl1 Tnn Fbn1 Lama3 Fras1 Tnr Fgl2 Tnc Otog Thsd4 Mgp Tnfaip6 Reln Gldn Gas6 Papln Fbn2 Igfbp2 Colq Tinagl1 Fndc1 Ltbp1 Bsph1 Crim1 Ltbp4 Ltbp2 Ltbp3 Tectb Egflam Tnxb Fndc8 Fndc7 Ctgf Wisp1 Tgfbi Npnt Vwa5b2 Vwce Smoc2 Mepe Igfbpl1 Smoc1 Pxdn Nell2 Nell1 Ntng1 Emilin1 Emilin3 Lrg1 Pcolce2 Emilin2 Dmbt1 Igfbp5 Efemp2 Fga Ddx26b Fgb Zpld1 Fgg Efemp1 Vwde Cilp Vwa5a Ambn Mfap5 Mfap4 Mfap2 Ntn1 Otol1 Ntn4 Ntn5 Thbs2 Thbs1 Igfals Mfge8 Mfap3 Thbs4 Thbs3 Lamb3 Sparcl1 Zp1 Lamb1 Edil3 Spp1 Cdcp2 Lamb2 Vtn Bmper Svep1 Abi3bp Ndnf Lgi4 Igfbp1 Lama4 Lgi3 Fbln7 Lgi2 Lgi1 Igfbp4 Lama5 Dmp1 Srpx2 Fbln5 Igsf10 Fbln2 Cilp2 Mfap1b Vwf Adipoq Ush2a Fn1 Matn1 Sparc Emid1 Dpt Igfbp7 Coch Cthrc1 Sbspon Slit1 Comp Sned1 Slit3 Vwa5b1 Tecta Crispld1 Igfbp3 Crispld2 Amelx Eln Agrn Nid1 Nid2 Matn3 Matn2 Vit Matn4 Spon1 Spon2 Aebp1 Cyr61 Nov Postn Mmrn2 Slit2 Vwa1 Lama1 Vwa2 Fbln1 Dspp Mmrn1 Vwa7 Tbc1d24 Vwa9 Lama2 Kcp PID_RHOA_REG_PATHWAY%MSIGDB_C2%PID_RHOA_REG_PATHWAY PID_RHOA_REG_PATHWAY Arhgef18 Plekhg6 Def6 Arap1 Myo9b Arhgap8 Arhgap9 Arhgef25 Ngef Arhgef28 Ect2 Arhgap35 Net1 Mcf2 Arhgdib Arhgdig Dlc1 Trio Farp1 Vav1 Akap13 Rhoa Arhgap5 Arhgdia Vav3 Arap3 Arhgef3 Arhgef10l Arhgef2 Srgap1 Ophn1 Arhgef1 Abr Arhgap4 Mcf2l Arhgap6 Arhgef10 Cdkn1b Arhgef11 Arhgef12 Arhgef15 Bcr Arhgef17 Vav2 ST_JNK_MAPK_PATHWAY%MSIGDB_C2%ST_JNK_MAPK_PATHWAY ST_JNK_MAPK_PATHWAY Mapk7 Tab2 Dusp10 Dusp8 Dld Map3k2 Shc1 Pappa Map3k3 Nfatc3 Trp53 Map3k5 Mapk10 Map2k7 Gab1 Map3k11 Gadd45a Mapk9 Gck Akt1 Map2k4 Zak Mapk8 Myef2 Dusp4 Map2k5 Atf2 Jun Map3k9 Traf6 Map3k4 Map3k1 Map3k12 Map3k13 Nr2c2 Tab1 Map3k10 Il1r1 Map3k7 HALLMARK_GLYCOLYSIS%MSIGDB_C2%HALLMARK_GLYCOLYSIS HALLMARK_GLYCOLYSIS Gne Chpf Qsox1 Ecd Copb2 Mertk Got1 Depdc1a Pcx Gys1 Fbp2 Isg20 B3gat3 B3gat1 Pygb Me2 Hs2st1 B4galt1 Cldn3 Chst2 Galk1 Pgm1 Ext1 Angptl4 Hk2 Sdc2 Sdc3 Rbck1 Stc1 Hspa5 Stc2 Zfp292 Efna3 Ppfia4 Kdelr3 Tgfbi Pam Cd44 Gpr87 B3gnt3 Dld Dsc2 Ndst3 Tpbg Pgam1 Pkm Eno1b Paxip1 Chst1 Hdlbp Chst4 Chst5 Cog2 Miox Adora2b Bpnt1 Bik Pmm2 Slc16a3 Slc35a3 Hax1 Gfpt1 B4galt4 B4galt7 B4galt2 Ext2 Kif2a Prps1 Pfkfb1 Lhpp Gys2 Il13ra1 Chst12 Homer1 Fut8 Xylt2 Nol3 Abcb6 Slc25a13 Polr3k Gnpda1 Aldh7a1 P4ha2 Idua Glce Rpe Gmppa Pkp2 Hs6st2 Gmppb Nanp Gal3st1 Srd5a3 Akr1a1 Lhx9 Cth Galk2 Alg1 Vldlr Cenpa Sap30 Psmc4 Mxi1 Cdk1 Pgls Aurka Gclc Cited2 Vegfa Me1 Tpi1 Fam162a Gpc3 Gpc4 Lct Ppia Pygl Pgam2 Mpi Met Slc25a10 Pgk1 Ugp2 Gpc1 Fkbp4 Ier3 Ndufv3 Ero1l Aldob Aldoa Dpysl4 Eno2 Eno1 Artn Mif Slc37a4 Nt5e Tktl1 Gapdhs B3galt6 P4ha1 Ankzf1 Ldha Stmn1 Ldhc Got2 Ddit4 Cxcr4 Med24 Dcn Rragd Taldo1 Ppp2cb Rars Elf3 Sdc1 Txn1 G6pdx Tsta3 Tgfa Gale Irs2 Hmmr Arpp19 Capn5 Cyb5a Casp6 Egfr Tff3 Pfkp Tpst1 Nasp Glrx Sdhc Ang Mdh1 Mdh2 Phka2 Aldh9a1 Cln6 Cacna1h Plod2 Agl Col5a1 Plod1 Igfbp3 Agrn Ak3 Pdk3 Nsdhl Egln3 Sox9 Gusb Idh1 Cldn9 Vcan Kif20a SA_G2_AND_M_PHASES%MSIGDB_C2%SA_G2_AND_M_PHASES SA_G2_AND_M_PHASES Cdkn1a Chek1 Cdc25a Cdc25b Cdk7 Wee1 Nek1 Cdk1 PID_ERBB2_ERBB3_PATHWAY%MSIGDB_C2%PID_ERBB2_ERBB3_PATHWAY PID_ERBB2_ERBB3_PATHWAY Sos1 Erbb3 Nrg1 Usp8 Shc1 Map2k1 Map2k2 Hras Src Mtor Chrne Rnf41 Dock7 Pik3ca Prkaca Fos Bad Jak2 Mapk10 Chrna1 Mapk9 Nf2 Akt1 Pik3r3 Pik3r1 Nfatc4 Mapk8 Pik3r2 Kras Pik3cb Stat3 Ptpn11 Grb2 Ppp3cb Pik3cd Jun Nrg2 Nras Erbb2 Mapk1 Mapk3 Raf1 Rac1 BIOCARTA_CELL2CELL_PATHWAY%MSIGDB_C2%BIOCARTA_CELL2CELL_PATHWAY BIOCARTA_CELL2CELL_PATHWAY Actn2 Actn3 Pecam1 Ctnna1 Vcl Ctnnb1 Csk Src Ptk2 Pxn Actn1 Ctnna2 Ctnna3 Bcar1 BIOCARTA_KERATINOCYTE_PATHWAY%MSIGDB_C2%BIOCARTA_KERATINOCYTE_PATHWAY BIOCARTA_KERATINOCYTE_PATHWAY Prkch Prkce Ikbkb Prkcq Ets1 Prkca Ets2 Fas Map2k1 Mapk14 Fasl Daxx Hras Prkcd Egf Map2k6 Map3k5 Fos Tnf Hoxa7 Tnfrsf1a Map2k7 Cebpa Tnfrsf1b Map2k4 Map2k3 Mapk13 Bcl2 Mapk8 Prkcg Traf2 Jun Map3k14 Egfr Prkcb Map3k1 Nfkbia Sp1 Ppp2ca Ripk1 Rela Nfkb1 Mapk1 Mapk3 Chuk Raf1 PID_INTEGRIN5_PATHWAY%MSIGDB_C2%PID_INTEGRIN5_PATHWAY PID_INTEGRIN5_PATHWAY Itgb6 Vtn Cyr61 Itgb7 Sdc1 Madcam1 Itgb5 Vcam1 Fn1 Itgb8 Plau Fbn1 Plaur Itgav Edil3 Itga4 Tgfbr1 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES%MSIGDB_C2%SIG_IL4RECEPTOR_IN_B_LYPHOCYTES SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Sos1 Jak1 Jak3 Gsk3b Ppp1r13b Gsk3a Stat6 Il4ra Shc1 Pik3ca Bad Map4k1 Irs2 Akt3 Akt1 Pdk1 Bcl2 Pik3r1 Akt2 Grb2 Pik3cd Irs1 Mapk1 Socs1 Mapk3 Raf1 Sos2 PID_NOTCH_PATHWAY%MSIGDB_C2%PID_NOTCH_PATHWAY PID_NOTCH_PATHWAY Sspo Adam10 Notch2 Ncor1 Maml2 Skp2 Dtx1 Notch3 Eps15 Ctbp1 Notch1 Kdm1a Psen1 Furin Ncor2 Maml1 Rbpj Spen Dll1 Notch4 Numb Cntn1 Itch Jag2 Mib1 Cntn6 Cul1 Mycbp Lnx1 Dll4 Dner Ncstn Dll3 Neurl1a Mark2 Ptcra Ep300 Rab11a Dlk1 Il4 Jag1 Adam12 Eno1b Fbxw7 Gata3 Ccnd1 Myc Hdac1 Aph1b Skp1a Mfap5 Mfap2 Dnm1 Cdkn1a Eno1 Rbbp8 Yy1 Cbl BIOCARTA_PLCE_PATHWAY%MSIGDB_C2%BIOCARTA_PLCE_PATHWAY BIOCARTA_PLCE_PATHWAY Rap2b Prkar1b Ptger1 Adcy1 Prkar1a Prkar2a Prkar2b Adrb2 Prkacb Plce1 PID_HIF1_TFPATHWAY%MSIGDB_C2%PID_HIF1_TFPATHWAY PID_HIF1_TFPATHWAY Cops5 Ldha Trf Creb1 Igfbp1 Ncoa2 Id2 Plin2 Hnf4a Lep Smad4 Tert Pfkl Furin Hmox1 Cxcl12 Fos Hk2 Cxcr4 Itgb2 Arnt Hdac7 Eng Akt1 Hif1a Gck Tfrc Rora Ndrg1 Smad3 Gata2 Cited2 Car9 Bhlhe41 Vegfa Slc2a1 Crebbp Pgm2 Ep300 Ets1 Hk1 Cp Pgk1 Pkm Eno1b Fech Abcg2 Abcb1a Pfkfb3 Epo Mcl1 Egln3 Ncoa1 Aldoa Bhlhe40 Jun Npm1 Eno1 Adm Tff3 Sp1 Edn1 Nt5e Nos2 Serpine1 PID_RHODOPSIN_PATHWAY%MSIGDB_C2%PID_RHODOPSIN_PATHWAY PID_RHODOPSIN_PATHWAY Pde6a Pde6g Gnb5 Guca1b Guca1a Grk1 Sag Gnb1 Rdh5 Lrat Pde6b Rgs9 Rgs9bp Gngt1 Rho Rdh12 Rpe65 Slc24a1 Gucy2f Gnat1 Gucy2e Cnga1 PID_MYC_REPRESS_PATHWAY%MSIGDB_C2%PID_MYC_REPRESS_PATHWAY PID_MYC_REPRESS_PATHWAY Pdgfrb Creb1 Tsc2 Gfi1 Id2 Smad4 Irf8 Itgb4 Ppp2r4 Nfya Itgb1 Nfyb Lgals1 Ndrg1 Smad3 Aldh9a1 Foxo3 Hdac3 Cflar Smad2 Wnt5a Cdkn1b Erbb2 Itga6 Dntt Hmgcs2 Ep300 Gtf2h2 Sfxn3 Tmem126a Mxd4 Csde1 Zfp36l1 Spi1 Tjp2 Tmeff2 Slc11a1 Fth1 Dnmt3a Sfrp1 Ccnd1 Rbl1 Myc Clu Col1a2 Cebpa Zbtb17 Hdac1 Gadd45a Ndrg2 Bcl2 Cdkn2b Ccl5 Ddit3 Nfyc Cdkn1a Dkk1 Tbp Sp1 Brca1 Max PID_REG_GR_PATHWAY%MSIGDB_C2%PID_REG_GR_PATHWAY PID_REG_GR_PATHWAY Icam1 Smarca4 Tsg101 Csf2 Vipr1 Gsk3b Hdac2 Creb1 Prl Ncoa2 Il2 Mapk14 Stat5b Fkbp5 Stat5a Egr1 Mmp1a Pou2f1 Trp53 Prkacb Prkaca Fos Sfn Mapk11 Akt1 Cdk5 Nr4a1 Cdk5r1 Mapk8 Stat1 Hsp90aa1 Sgk1 Rela Krt5 Nfkb1 Mapk1 Mapk3 Ywhah Krt14 Il6 Crebbp Sele Ep300 Il5 Il4 Il13 Ifng Spi1 Afp Gata3 Nfatc1 Fgg Irf1 Nr3c1 Smarcc1 Mapk10 Fkbp4 Mdm2 Pomc Mapk9 Hdac1 Bax Ncoa1 Cdkn1a Jun Tbp Tbx21 Csn2 Smarcd1 Krt17 Cga Pck2 Pou1f1 Ppp5c Suv420h1 Nr1i3 Pbx1 Smarcc2 BIOCARTA_CDMAC_PATHWAY%MSIGDB_C2%BIOCARTA_CDMAC_PATHWAY BIOCARTA_CDMAC_PATHWAY Prkca Cuzd1 Map2k1 Jun Nfkbia Hras Prkcb Rela Nfkb1 Mapk1 Mapk3 Plcb1 Fos Myc Raf1 Tnf BIOCARTA_P53HYPOXIA_PATHWAY%MSIGDB_C2%BIOCARTA_P53HYPOXIA_PATHWAY BIOCARTA_P53HYPOXIA_PATHWAY Abcb1a Mdm2 Gadd45a Hif1a Akt1 Atm Bax Mapk8 Ep300 Hic1 Rpa1 Cdkn1a Igfbp3 Nfkbib Taf1 Hsp90aa1 Csnk1a1 Nqo1 Trp53 Fhl2 Csnk1d Hspa1a PID_FCER1_PATHWAY%MSIGDB_C2%PID_FCER1_PATHWAY PID_FCER1_PATHWAY Sos1 Lcp2 Ikbkb Cblb Lat2 Fcgr2b Shc1 Map2k1 Map2k2 Hras Gab2 Pxn Fos Syk Akt1 Dusp1 S1pr1 Dok1 Mapk8 Inpp5d Ptpn11 Sphk1 Fcer1g Pla2g4a Ikbkg Rela Nfkb1 Pld2 Mapk1 Mapk3 Chuk Raf1 Rasa1 Nfatc2 Plcg1 Pik3ca Ptpn13 Fer Map2k7 Btk Map2k4 Lat Pik3r1 Ms4a2 Pla2g1b Hcls1 Pak2 Fcer1a Vav1 Ppap2a Wipf1 Fyn Grb2 Klrg1 Jun Itk Map3k1 Prkcb Ptk2 Lyn Cbl PID_ERBB1_DOWNSTREAM_PATHWAY%MSIGDB_C2%PID_ERBB1_DOWNSTREAM_PATHWAY PID_ERBB1_DOWNSTREAM_PATHWAY Sos1 Eps8 Ksr1 Ywhaz Usp6nl Prkca Mlst8 Bcl2l1 Map2k1 Map2k2 Pdpk1 Smad1 Hras Egr1 Mtor Egf Braf Sfn Fos Rictor Ppp2r2a Zfp36 Stat1 Ywhae Stat3 Rala Ywhab Mapkap1 Nras Mapk1 Mapk3 Ywhah Ywhag Raf1 Rac1 Diap3 Ralgds Srf Gab1 Brk1 Baiap2 Atf2 Elk1 Rab5a Egfr Map3k1 Ppp2ca Ppp2r1a Rps6ka5 Mef2c Creb1 Arf4 Mylpf Iqgap1 Akt1 Dusp1 Nckap1 Mapk8 Abi1 Cyfip2 Pik3cb Arpc5 Pld2 Arpc2 Wasf2 Arpc3 Pld1 Arpc4 Actr3 Actr2 Vav2 Arpc1b Mapk7 Map3k2 Src Prkcd Pik3ca F2rl2 Capn2 Bad Prkcz Slc9a1 Wasl Mapk9 Sh2d2a Pik3r3 Map2k4 Pik3r1 Rps6ka3 Pik3r2 Dusp6 Kras Grb2 Pik3cd Map2k5 Jun Rps6ka4 Pebp1 Ppp5c Rin1 BIOCARTA_NOS1_PATHWAY%MSIGDB_C2%BIOCARTA_NOS1_PATHWAY BIOCARTA_NOS1_PATHWAY Grin2d Dlg4 Grin2a Grin2c Prkar2a Prkar2b Grin1 Nos1 Prkca Ppp3cc Ppp3ca Ppp3cb Prkar1b Grin2b Prkar1a Prkcb Prkacb BIOCARTA_KREB_PATHWAY%MSIGDB_C2%BIOCARTA_KREB_PATHWAY BIOCARTA_KREB_PATHWAY Sdha Ogdh Sucla2 Mdh1 Idh2 Aco2 Fh1 Cs ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS%MSIGDB_C2%ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Crebbp Creb1 Egr4 Shc1 Th Src Egr2 Egr1 Terf2ip Braf Opn1mw Pik3ca Egr3 Pik3c2g Mapk10 Map2k7 Crkl Tuba1a Mapk9 Gnaq Akt1 Map2k4 Map1b Pik3r1 Rps6ka3 Mapk8 Frs2 Ptpn11 Pik3cd Jun Elk1 Asah1 Dag1 Mapk8ip3 Mapk8ip2 Ntrk1 Mapk8ip1 Mapk1 Gast Mapk3 Creb3 Camp BIOCARTA_MAL_PATHWAY%MSIGDB_C2%BIOCARTA_MAL_PATHWAY BIOCARTA_MAL_PATHWAY Rock1 Acta1 Hnf1a Mapk8 Limk1 Rhoa Map2k1 Map2k2 Mal Diap1 Map3k1 Hras Srf Mapk1 Mapk3 Map4k2 Raf1 Rac1 PID_IL23_PATHWAY%MSIGDB_C2%PID_IL23_PATHWAY PID_IL23_PATHWAY Il1b Cd4 Il6 Itga3 Il24 Ifng Il12b Il2 Il17a Stat5a Stat4 Cxcl3 Tyk2 Cxcl9 Pik3ca Il18r1 Cd3e Jak2 Il23r Il18 Il12rb1 Ccl12 Tnf Alox12b Il23a Pik3r1 Stat1 Stat3 Socs3 Il19 Nfkbia Il18rap Il17f Rela Nfkb1 Mpo Nos2 PID_CDC42_REG_PATHWAY%MSIGDB_C2%PID_CDC42_REG_PATHWAY PID_CDC42_REG_PATHWAY Apc Dock11 Itsn2 Spata13 Fgd1 Dock6 Farp2 Dock10 Arhgef25 Arhgap17 Ngef Itsn1 Mcf2 Racgap1 Git1 Plcg1 Dnmbp Nme1 Arhgef9 Vav3 Arhgdia Arhgef6 Arhgap1 Mcf2l Ralbp1 Bcar3 Arhgef7 Vav2 BIOCARTA_SKP2E2F_PATHWAY%MSIGDB_C2%BIOCARTA_SKP2E2F_PATHWAY BIOCARTA_SKP2E2F_PATHWAY Tfdp1 Ccna1 Skp1a Rb1 Cdc34 Ccne1 Cul1 Cdk2 Skp2 E2f1 PID_IGF1_PATHWAY%MSIGDB_C2%PID_IGF1_PATHWAY PID_IGF1_PATHWAY Sos1 Igf1r Igf1 Ywhaz Shc1 Pdpk1 Hras Gnb2l1 Prkcd Ptpn1 Prkd1 Pik3ca Pxn Bad Prkcz Bcar1 Irs2 Crkl Crk Nck2 Akt1 Grb10 Pik3r1 Ywhae Ptpn11 Grb2 Ptk2 Irs1 Raf1 NABA_MATRISOME_ASSOCIATED%MSIGDB_C2%NABA_MATRISOME_ASSOCIATED NABA_MATRISOME_ASSOCIATED Adamts1 Lman1 C1qc C1qa C1qb Cxcl11 Ctse Cxcl10 Ctsb Csf1 Cxcl13 Ebi3 Ltb Elane Inhbe Cxcl3 Cxcl9 Cxcl2 Pf4 A2m Ccl7 Il7 Pdgfc Plau P4ha2 Kitl Serpine1 Wnt9b Wnt9a Nrg3 Nrg4 Megf8 Ereg S100g Gdf9 S100z Gdf5 S100b Megf9 Gdf2 Gdf3 Gdf6 Gdf7 Lep Ism2 Wnt8a Il2 Tpo Fasl Wnt8b Tnfsf12 Tnfsf15 Tnfsf14 Sftpa1 Ism1 Nodal Bdnf Fgf18 Tnfsf18 Wnt7b Fgf17 Fgf14 Fgf15 Fgf11 Wnt7a Fgf10 Fgf13 Fgf12 Insl6 Vwc2l Angptl7 Angptl6 Tchhl1 Angptl2 Angptl1 Insl3 Pik3ip1 Fgf23 Mdk Fgf20 Fgf21 Il17b Ptn Il17d Il17c Flt3l Tgfb1 Il17f Ccl22 Ccl28 Tnfsf4 Ccl24 Lefty2 Ccl20 Tnfsf8 Frzb Il1b Il6 Igf1 Il1f5 Il1f6 Il24 Il20 Il5 Il25 Ccl11 Cd209a Il4 Il1f8 Il1f9 Cxcl14 Ctf1 Fgfbp1 Fgfbp3 Vegfb Tnfsf11 Vegfc Fgf1 Fgf3 Anxa4 Fgf5 Fgf6 Fgf7 Ins2 Fgf8 Fgf9 Il34 Gpc1 Megf6 Cbln1 Ntf5 Cbln2 Bmp3 Bmp5 Serpinc1 Wfikkn2 Wfikkn1 Vwc2 Areg Amh Il11 Bmp6 Cbln3 Cbln4 Brinp2 Il19 Nrtn Artn Zfp91 Adam15 Nrg2 Crhbp Brinp3 Flg2 Adam23 Il1rn Bmp8a Eda Rptn Figf Ifne Ifnk Adamts5 Megf10 Megf11 Plxdc2 Anxa11 Parm1 Plxdc1 Cd209d Reg2 Clec1b Clec1a Prl Reg4 Lgals2 Clec11a Clec10a Muc13 Lgals9 Anxa10 Muc15 Lgals4 Clec4e Clec4g Clec4d Ctsd Elfn1 Clec4n Egf Muc4 Mmp1a Clec4f Adam17 Gpc6 Gpc2 Elfn2 Gpc5 Clec2l Clec3b Clec3a Muc20 Anxa3 Plxna2 Plxna1 Plxna4 Plxna3 Fcnb Sema7a Lif Anxa8 Anxa6 Anxa7 C1ql3 C1ql4 C1ql1 C1ql2 Sema6a Clec4a2 Sema6c Itln1 Lgals8 Clec18a Lgalsl Sftpb Sftpc Clec12a Clec12b Cspg5 Tgfb3 Lman1l Plxnc1 Cspg4 Lgals12 Plxnd1 Clec14a Plxnb3 Sdc1 Egln2 Ctss Epo Mep1a F12 Serping1 Ctsh Ctsl Ctsk Ctso Adam9 Mmp10 Mmp15 F13b Mmp11 Mmp14 Timp3 Bmp2 Serpina1d Serpina1a Clec5a Bmp1 Hyal3 Mmp8 Hyal1 Pappa Kazald1 Htra4 Serpinb3a Serpinb3d Hyal2 Tgm4 Angpt2 Tgm5 Mmp2 Htra3 Masp2 Angpt4 Htra1 Tgm6 Angpt1 Anxa1 Adamdec1 Tgm3 Mmp7 Plg F2 Lgals1 Fgf2 Sema4d Fst Chrd Grem1 Serpina6 Bmp4 Bmp7 Mmp23 Plod2 Mmp25 Nrg1 Mmp24 P3h3 Fam20c Cstl1 Fam20b Adamts7 Il9 Mmp17 Ifna16 Adamts8 Adamts6 Lta F13a1 Sema3c Il10 Mmp16 Il16 Plod1 Il15 Shh Plod3 Il13 Mmp21 Sulf1 Mmp20 Adam30 Adam32 Adam33 Tll1 Adamts13 Mmp27 P3h2 Fam20a Mmp28 P3h1 2010005H15Rik Mep1b Sulf2 Serpinb10 Serpina12 Serpina11 Pcsk6 Serpinb13 Serpinb12 Serpinb11 Egln3 Cst7 Cst6 Hyal5 Hyal4 Pcsk5 Cst9 Cst8 Ngly1 Ctsa Cela1 Timp1 Adamts3 Ctsf Ctsc Adamts4 Hpse Adamts2 Mmp19 St14 Ctsz Cst3 Pappa2 Astl Fgf4 Cstb Ctsw Ngf Serpinb1a Adam18 Adam19 Csf2 Ky Ambp Adam11 Adam10 Cst11 Adamts20 Cst10 Serpind1 Itih5 Cela3b Itih2 Cpn2 Serpinb7 Serpinb9 Prss12 Osm Adam29 Inha Adamts14 Adam28 Adamts15 Pgf Tll2 Adamts16 Adamts18 F9 Adamts19 Pamr1 Slpi Anxa2 Hpse2 Adam21 Angptl4 Adam22 Adamts10 Adamts12 Ccl12 P4ha3 Sdc2 Serpina10 Sdc3 Adam8 Adam7 Sdc4 Lgals7 Serpini2 Tgfb2 Ogfod2 Tmprss15 Gdnf Serpinh1 Ntf3 Adam2 Lox Habp2 Serpinf2 Serpina3n Ogfod1 F7 Loxl4 Loxl3 Tgm2 Serpinf1 Timp4 Adamtsl1 Tgm1 Serpinb8 Prss2 Adamtsl3 Adamtsl4 Adamtsl2 Timp2 Serpina7 Serpina5 Adamtsl5 Serpina9 Serpinb6a Serpini1 Cela2a Cd109 Wnt16 Serpinb2 P4htm Itih3 Loxl1 Loxl2 Serpine3 Serpine2 Fgf22 Insl5 Fgf16 Mmp3 Pdgfd Ctsg Mmp9 Mmp13 Mmp12 Csf3 Hgf Il1a Pdgfa Tnf Tnfsf13b Vegfa Tnfsf13 Kng2 Gpc3 Gpc4 S100a4 Il17a Frem2 Frem1 Sema4g Sema4f Sema4c Sema4b Sema4a Clec4b2 Sema6b Sema6d Reg3b Reg3g Sema5b Sema5a Emcn Frem3 C1qtnf9 Clec9a C1qtnf2 C1qtnf1 Pdgfb Hpx C1qtnf7 Ovgp1 Clec7a Ccl4 Colec12 Colec11 Sema3f Sema3g Sema3e Colec10 Sema3a P4ha1 Sema3d Wnt1 Serpinb5 Cxcl12 Clcf1 Tnfsf10 Chrdl2 Scube3 Wnt5b Wnt5a S100a9 S100a8 Crnn Scube1 S100a5 S100a3 Wif1 S100a6 Epgn Cxcl5 Xcl1 Mstn Ifnb1 Cxcl1 S100a1 Tchh Hgfac Cx3cl1 Gdf15 Reg1 Iltifb Gdf10 Cntf Tgfa Hhip Btc Wnt3a Ifng Sfrp5 Il12b Bmp15 Wnt2b Il1f10 Plxnb1 Gdf11 Hrg Sfrp1 Sfrp2 Il12a Sfrp4 Egfl6 Egfl7 Crlf3 Crlf1 Bmp10 Hbegf Il18 Egfl8 Thpo Wnt10b Wnt10a Ccl1 Dhh Il23a Mst1 Hcfc2 Hcfc1 S100a14 Inhbc S100a13 Pspn Lefty1 Ccl5 Ccl2 Ccl3 Wnt3 Agt Wnt11 S100a16 Wnt2 Inhbb S100a10 Inhba Muc1 Ccbe1 Fstl3 Fstl1 Wnt6 Sftpd Igf2 Ppbp Ihh Ccl17 Wnt4 Anxa9 Plat Itih4 Ccl25 Itih1 Mbl2 Angptl3 S100a11 Plxnb2 Adam12 Lgals3 F10 Sema3b Anxa5 HALLMARK_APOPTOSIS%MSIGDB_C2%HALLMARK_APOPTOSIS HALLMARK_APOPTOSIS Lef1 Isg20 Dffa Pdcd4 Bcl2l1 Igfbp6 Psen1 Lmna Atf3 Casp2 Casp4 Sat1 Psen2 Hmox1 Bgn Ank Tgfbr3 Lum Dcn Tgfb2 Xiap Bcap31 Rhob Dap3 Cflar Ccna1 Tnfsf10 H1f0 Casp8 Smad7 Timp2 Erbb2 Pea15a Rock1 Crebbp Ifnb1 Cd44 Cdc25b Cyld Pak1 Gsr Dnajc3 Birc3 Casp7 Txnip Cd14 Btg2 Madd Sqstm1 Krt18 Btg3 Ifngr1 Ccnd1 Cdk2 Bik Irf1 Il18 F2r Tap1 Cd2 Mcl1 Cd38 Hspb1 Bax Bid Casp6 Casp3 Casp9 Cdkn1a Gpx4 Gstm2 Gpx3 Ptk2 Brca1 Ifitm3 Nefh Cth Gna15 Plcb2 Timp3 Add1 Erbb3 Bmp2 Pdgfrb Prf1 Ereg Il1a Hgf Casp1 Fas Bcl10 Fasl Mmp2 Plat Egr3 Anxa1 Gpx1 Ppp3r1 Gucy2e Tnf F2 Top2a Satb1 Diablo Igf2r Bnip3l Tspo Cav1 Rela Cdkn1b Rara Ppp2r5b Ppt1 Gch1 Il1b Il6 Avpr1a Dap Slc20a1 Bcl2l2 Bcl2l10 Ctnnb1 Mgmt Sptan1 Cd69 Vdac2 Tnfrsf12a Nedd9 Ebp Rhot2 Lgals3 Aifm3 Rnasel Hmgb2 Bmf Lppr4 Dpyd Clu Dnm1l Emp1 Fez1 Ccnd2 Ier3 Gadd45a Retsat Dnaja1 Gsn Etf1 Sod2 App Ddit3 Eno2 Timp1 Jun Gadd45b Wee1 Fdxr Sc5d Bcl2l11 BIOCARTA_SRCRPTP_PATHWAY%MSIGDB_C2%BIOCARTA_SRCRPTP_PATHWAY BIOCARTA_SRCRPTP_PATHWAY Cdc25c Csk Prkcb Src Cdc25a Cdc25b Prkca Ptpra Cdk1 Grb2 ST_JAK_STAT_PATHWAY%MSIGDB_C2%ST_JAK_STAT_PATHWAY ST_JAK_STAT_PATHWAY Jak1 Jak3 Cish Ptpru Reg1 Pias1 Pias3 Soat1 Jak2 BIOCARTA_P38MAPK_PATHWAY%MSIGDB_C2%BIOCARTA_P38MAPK_PATHWAY BIOCARTA_P38MAPK_PATHWAY Creb1 Mef2d Rapgef2 Mknk1 Shc1 Mapk14 Daxx Hras Map2k6 Map3k5 Myc Tgfb2 Mapkapk5 Map2k4 Hspb1 Stat1 Hspb2 Grb2 Ddit3 Atf2 Traf2 Elk1 Map3k9 Pla2g4a Map3k1 Tradd Ripk1 Tgfb1 Tgfb3 Rps6ka5 Max Map3k7 Mapkapk2 Mef2c Mef2a Tgfbr1 Rac1 PID_WNT_NONCANONICAL_PATHWAY%MSIGDB_C2%PID_WNT_NONCANONICAL_PATHWAY PID_WNT_NONCANONICAL_PATHWAY Rock1 Fzd7 Tab2 Camk2a Arrb2 Dvl1 Dvl3 Cthrc1 Fzd5 Yes1 Nfatc2 Csnk1a1 Flna Dvl2 Prkcz Mapk10 Mapk9 Ror2 Fzd2 Fzd6 Setdb1 Mapk8 Chd7 Pparg Rhoa Nlk Daam1 Wnt5a Tab1 Map3k7 Rac1 PID_ERBB_NETWORK_PATHWAY%MSIGDB_C2%PID_ERBB_NETWORK_PATHWAY PID_ERBB_NETWORK_PATHWAY Nrg3 Erbb3 Nrg1 Nrg4 Erbb4 Ereg Areg Tgfa Btc Nrg2 Egfr Hsp90aa1 Egf Erbb2 Hbegf BIOCARTA_PTC1_PATHWAY%MSIGDB_C2%BIOCARTA_PTC1_PATHWAY BIOCARTA_PTC1_PATHWAY Xpo1 Cdc25c Cdc25a Mnat1 Cdc25b Cdk7 Ccnh Shh Cdk1 Ptch1 HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION%MSIGDB_C2%HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION Gem Mcm7 Qsox1 Ecm1 Notch2 Msx1 Ecm2 Pcolce Lamc2 Fuca1 Lamc1 Mmp1a Fbn1 Lama3 Flna Cxcl12 Col16a1 Sat1 Tnc Bgn Cdh2 Mgp Gja1 Tgfbr3 Lum Sdc4 Dcn Col11a1 Serpinh1 Lox Fbn2 Col12a1 Prrx1 Igfbp2 Rhob Tgm2 Pfn2 Wnt5a Dab2 Capg Ctgf Tgfbi Itga2 Pmp22 Cxcl5 Ppib Sdc1 Cd44 Tnfaip3 Loxl1 Pcolce2 Cxcl3 Loxl2 Sfrp1 Itgb3 Serpine2 Sfrp4 Col8a2 Efemp2 Crlf1 Col1a2 Col5a3 Col5a2 Slc6a8 Mfap5 Mylk Thbs2 Thbs1 Mmp3 Anpep Inhba Lrp1 Fstl3 Fstl1 Itgav Edil3 Spp1 Copa Thy1 Serpine1 Mmp14 Timp3 Sgcb Dpysl3 Foxc2 Abi3bp Calu Pdgfrb Basp1 Lrrc15 Colgalt1 Nnmt Magee1 Sntb1 Tfpi2 Id2 Cap2 Itgb5 Cd59b Bmp1 Fermt2 Glipr1 Vcam1 Ntm Igfbp4 Fas Fbln5 Col4a2 Fbln2 Col4a1 Mmp2 Bdnf Oxtr Htra1 Itgb1 Fap Gpx7 Pdlim4 Tagln Rgs4 Fzd8 Lgals1 Fgf2 Mest Itga5 Fn1 Col6a3 Emp3 Col6a2 Sgcd Grem1 Col3a1 Tgfb1 Aplp1 Vegfa Ptx3 Sgcg Scg2 Plod2 Cadm1 Myl12a Col7a1 Il6 Sparc Cdh11 Col5a1 Cthrc1 Tnfrsf11b Comp Slit3 Il15 Plod1 Plod3 Cdh6 Adam12 Igfbp3 Eln Tnfrsf12a Vegfc Plaur Nid2 Matn3 Matn2 P3h1 Fmod Gpc1 Gas1 Cyr61 Postn Gadd45a Slit2 Lama1 Fbln1 Areg Spock1 Wipf1 Pthlh Lama2 Timp1 Eno2 Jun Dkk1 Pmepa1 Gadd45b Vim Tpm2 Nt5e Vcan Col1a1 Snai2 BIOCARTA_PGC1A_PATHWAY%MSIGDB_C2%BIOCARTA_PGC1A_PATHWAY BIOCARTA_PGC1A_PATHWAY Camk2a Camk1g Hdac5 Slc2a4 Camk1 Camk2b Mef2d Camk4 Ppp3cc Ppp3ca Camk2d Camk2g Ppp3cb Ppargc1a Ywhah Mef2c Esrra Mef2a Ppara BIOCARTA_P27_PATHWAY%MSIGDB_C2%BIOCARTA_P27_PATHWAY BIOCARTA_P27_PATHWAY Nedd8 Ube2m Skp1a Ccne1 Cul1 Rbx1 Skp2 E2f1 Tfdp1 Cks1b Rb1 Cdkn1b Cdk2 BIOCARTA_PTDINS_PATHWAY%MSIGDB_C2%BIOCARTA_PTDINS_PATHWAY BIOCARTA_PTDINS_PATHWAY Prkce Ap2m1 Btk Gsk3b Akt1 Arf1 Gsk3a Pfkm Ap2a1 Jag1 Rab5a Pdpk1 Pfkl Arhgef2 Pfkp Plcg1 Lyn Eea1 Bad Prkcz Rac1 Vav2 BIOCARTA_GLYCOLYSIS_PATHWAY%MSIGDB_C2%BIOCARTA_GLYCOLYSIS_PATHWAY BIOCARTA_GLYCOLYSIS_PATHWAY Tpi1 Eno1 Pgk1 Pfkl Pgam1 Gpi1 Pklr Eno1b Aldob Hk1 BIOCARTA_NUCLEARRS_PATHWAY%MSIGDB_C2%BIOCARTA_NUCLEARRS_PATHWAY BIOCARTA_NUCLEARRS_PATHWAY Abcb1a Nr1h4 Nr0b2 Nr1h3 Pparg Abcb11 Abcb4 Ppard Rara Abcc3 Nr1i3 Cyp1a2 Cyp2e1 Ppara SA_PTEN_PATHWAY%MSIGDB_C2%SA_PTEN_PATHWAY SA_PTEN_PATHWAY Sos1 Akt3 Ilk Akt1 Pdk1 Akt2 Ipcef1 Grb2 Pik3cd Shc1 Pten Ptk2b Pik3ca Mapk1 Bpnt1 Mapk3 Rbl2 PID_PDGFRA_PATHWAY%MSIGDB_C2%PID_PDGFRA_PATHWAY PID_PDGFRA_PATHWAY Sos1 Jak1 Crkl Crk Pik3r1 Rapgef1 Pdgfra Grb2 Shc1 Ifng Jun Elk1 Shb Shf Cav1 Plcg1 Srf Pik3ca Cav3 Itgav Fos PID_TCPTP_PATHWAY%MSIGDB_C2%PID_TCPTP_PATHWAY PID_TCPTP_PATHWAY Sos1 Jak1 Jak3 Pdgfrb Crebbp Lman1 Hgf Csf1 Stat6 Rab4a Shc1 Met Stat5b Stat5a Src Egf Eif2ak2 Ptpn1 Pik3ca Pias1 Itgb1 Ins2 Insr Eif2a Gab1 Ptpn2 Pik3r3 Pik3r1 Pik3r2 Stat1 Csf1r Pik3cb Stat3 Grb2 Pik3cd Pdgfb Egfr Kdr Vegfa Itga1 Kpnb1 HALLMARK_MITOTIC_SPINDLE%MSIGDB_C2%HALLMARK_MITOTIC_SPINDLE HALLMARK_MITOTIC_SPINDLE Apc Ywhaq Sos1 Anln Ccdc88a Tlk1 Kif4 Kifap3 Actn4 Tubd1 Notch2 Clasp1 Palld Hook3 Pkd2 Tsc1 Kptn Nin Ppp4r2 Kif11 Kif15 Clip2 Ssh2 Cenpj Map1s Dynll2 Cep250 Marcks Synpo Pcm1 Katnb1 Brca2 Sass6 Mapre1 Kntc1 Llgl1 Rapgef5 Smc3 Shroom1 Flna Clip1 Plk1 Cdk5rap2 Lrpprc Pxn Rab3gap1 Cntrob Bcar1 Arhgap10 Atg4b Rictor Hdac6 Sptbn1 Pcgf5 Dync1h1 Ywhae Arl8a Dlgap5 Lats1 Vcl Dock4 Cep72 Ophn1 Myh9 Cep131 Arhgap4 Rapgef6 Mark4 Fgd6 Ckap5 Fgd4 Stk38l Tubgcp2 Plekhg2 Mid1 Mid1ip1 Sac3d1 Cdc42ep2 Rabgap1 Cdc42ep1 Cdc42ep4 Rock1 Dock2 Fbxo5 Cenpf Cenpe Arfgef1 Smc1a Flnb Nusap1 Wasf1 Racgap1 Nek2 Uxt Cdc42bpa Gemin4 Map3k11 Cyth2 Farp1 Kif20b Arhgdia Arhgap5 Arhgef3 Arhgef2 Rasal2 Kif23 Arhgef11 Arhgef12 Arfip2 Arhgef7 Kif22 Abl1 Katna1 Pcnt Espl1 Smc4 Prex1 Myo9b Kif5b Ect2 Itsn1 Net1 Epb4.1 Ttk Birc5 Kif2c Cdc27 Csnk1d Pdlim5 Cdk1 Pif1 Tiam1 Top2a Aurka Dlg1 Lmnb1 Kif1b Abi1 Bub1 Ccnb2 Wasf2 Myh10 Cttn Klc1 Bin1 Tuba4a Ndc80 Numa1 Myo1e Rhof Rasa1 Sptan1 Nedd9 Rhot2 Arf6 Rfc1 Shroom2 Cd2ap Tpx2 Wasl Ezr Prc1 Gsn Nck2 Trio Nck1 Akap13 Cep57 Rasa2 Arap3 Kif3c Fscn1 Pafah1b1 Als2 Arhgap29 Abr Ranbp9 Incenp Kif3b Ralbp1 Alms1 Sun2 Sept9 Tbcd Nf1 Stau1 Capzb Bcl2l11 Tubgcp3 Bcr Tubgcp5 Epb4.1l2 PID_AR_NONGENOMIC_PATHWAY%MSIGDB_C2%PID_AR_NONGENOMIC_PATHWAY PID_AR_NONGENOMIC_PATHWAY Plcb3 Gnai2 Creb1 Gnb1 Map2k1 Map2k2 Hras Src Plcg1 Pik3ca Fos Akt1 Plcg2 Ar Pik3r1 Shbg Gnai3 Gnao1 Gnaz Gnrh1 Ptk2 Gnai1 Mapk1 Gng2 Mapk3 Plcb1 Raf1 Plcb2 Pelp1 Rac1 PID_INTEGRIN1_PATHWAY%MSIGDB_C2%PID_INTEGRIN1_PATHWAY PID_INTEGRIN1_PATHWAY Vtn Lama4 Vcam1 Lama5 Lamc2 Col2a1 Col4a4 Lamc1 Col4a3 Fbn1 Col4a1 Lama3 Col18a1 Itgb1 Tnc Cd81 Col11a1 Col11a2 Itga5 Tgm2 Mdk Fn1 Col6a3 Col6a2 Itga11 Col3a1 Itga10 Itga8 Itga9 Vegfa Itga6 Cspg4 Itga7 Itga4 Npnt Itga2 Tgfbi Itga1 Col7a1 Col6a1 Col5a1 Itga3 F13a1 Cd14 Plaur Nid1 Fga Fgb Fgg Col1a2 Col5a2 Igsf8 Jam2 Lama1 Col4a5 Col4a6 Lama2 Thbs2 Thbs1 Plau Lamb3 Col1a1 Lamb1 Itgav Spp1 Lamb2 PID_ER_NONGENOMIC_PATHWAY%MSIGDB_C2%PID_ER_NONGENOMIC_PATHWAY PID_ER_NONGENOMIC_PATHWAY Sos1 Igf1r Plcb3 Gnai2 Igf1 Gnb1 Shc1 Esr2 Src Hras Pik3ca Mmp2 Rock2 Bcar1 Hbegf Nos3 Mapk11 Gnaq Akt1 Msn Pik3r1 Gnal Kras Gna11 Gnai3 Grb2 Rhoa Gnao1 Gnaz Strn Gna13 Mmp9 Nras Esr1 Gna14 Gnai1 Gng2 Plcb1 Gna15 Plcb2 Pelp1 BIOCARTA_CBL_PATHWAY%MSIGDB_C2%BIOCARTA_CBL_PATHWAY BIOCARTA_CBL_PATHWAY Sh3kbp1 Pdgfra Prkca Csf1r Sh3glb2 Sh3glb1 Grb2 Met Egfr Src Prkcb Egf Cbl PID_RAC1_REG_PATHWAY%MSIGDB_C2%PID_RAC1_REG_PATHWAY PID_RAC1_REG_PATHWAY Sos1 Def6 Dock2 Spata13 Eps8 Dock6 Prex1 Kalrn Arhgap9 Arhgef25 Arhgap17 Ngef Elmo1 Mcf2 Racgap1 Rap1gds1 Tiam2 Tiam1 Trio Rasgrf1 Vav1 Abi1 Vav3 Arhgdia Arhgef2 Abr Arhgef6 Arhgap1 Ralbp1 Dock1 Arhgef7 Bcr Vav2 Rac1 BIOCARTA_CHREBP2_PATHWAY%MSIGDB_C2%BIOCARTA_CHREBP2_PATHWAY BIOCARTA_CHREBP2_PATHWAY Prkab1 Ppp2r2b Prkar2a Prkar2b Ywhaz Prkag1 Prkag3 Prkag2 Prkab2 Ppp2r1b Prkaa1 Prkaa2 Ppp2r5a Ppp2r2d Mlxipl Ppp2r5e Mlx Ppp2r4 Prkacb Ppp2r5d Ppp2r3a Fasn Ppp2r5c Prkaca Pklr Gck Ppp2r2a Ywhae Ppp2cb Prkar1b Prkar1a Ywhab Ppp2ca Acaca Ppp2r1a Ppp2r2c Ppp2r5b Ywhah Ywhag HALLMARK_COMPLEMENT%MSIGDB_C2%HALLMARK_COMPLEMENT HALLMARK_COMPLEMENT Lcp2 Car2 Usp8 Dusp5 Pim1 Cebpb Was Ctsd Psen1 Ehd1 Casp4 Jak2 Fcnb C1qc Pla2g7 C9 C1rb F7 C1qa Rhog Ppp2cb Pfn1 Dock4 Fcer1g Pla2g4a Prss2 Hspa5 Rasgrp1 Timp2 S100a9 Sirt6 Irf7 Xpnpep1 Pik3r5 Raf1 Atox1 Psmb9 Gnai2 Ltf Serpinb2 Ctsb Lap3 Kcnip3 Irf2 Gp1ba Cd40lg Casp7 Tnfaip3 Usp15 Lta4h Gata3 Cxcl3 Lamp2 Zeb1 Irf1 Tmprss6 Ctss Gnb2 Prep Kif2a C1s2 Olr1 S100a13 Cpq F8 Sh2b3 Ccl5 Serping1 Casp3 Casp9 Pik3cg C2 Ctsh Ctsl Ctso Lrp1 Lyn Adam9 Gng2 Mmp15 Serpine1 Mmp14 Klkb1 Scg3 Cda Serpina1d Serpina1a Gzmb Mmp13 Cblb Mmp12 Dock10 Plek Cfh Tfpi2 Cd36 Cd59b Ang Hnf4a Casp1 Mmp8 Kynu Dyrk2 Apoc1 Rabif Gngt2 Col4a2 Gp9 Plat Itgam Dpp4 Csrp1 Cfb Plg Notch4 F2 Gpd2 Pclo Mt3 Cd46 Rce1 Cdk5r1 Msrb1 Gca Usp16 Usp14 Rnf4 Dgkg Gnai3 Prss36 Itih1 Fn1 Adra2b Gmfb Brpf3 Vcpip1 Phex Prdm4 Gnb4 Akap10 Pdp1 Hpcal4 Apoa4 Lipa Rbsn Fdx1 Me1 Cpm Hspa1a Gzmk Ppp4c Cdh13 Il6 Prcp Zfpm2 F3 Dgkh Cr2 F5 Cp Stx4a Src Prkcd Lgals3 Pik3ca Plaur Clu Actn2 F10 Serpinc1 Spock2 C3 Lck Gzma Dusp6 Fyn Grb2 Timp1 Anxa5 Lgmn Pdgfb Ctsc Pcsk9 Plscr1 Maff PID_LYSOPHOSPHOLIPID_PATHWAY%MSIGDB_C2%PID_LYSOPHOSPHOLIPID_PATHWAY PID_LYSOPHOSPHOLIPID_PATHWAY Adcy1 Gsk3b Slc9a3r2 Adcy4 Adcy3 Adcy8 Adcy5 Magi3 Lpar4 Hras Mmp2 Pxn Adcy9 Fos Bcar1 Tiam1 Gnaq Crk Akt1 Gna11 Pik3cb Gnai3 Rhoa Lpar2 Gnao1 Lpar3 Gnaz Nfkbia Rela Nfkb1 Pld2 Rac1 Lpar1 Plcb3 Il6 Prkce Gnai2 Adcy2 Gnb1 Src Trip6 Prkcd Prkd1 Plcg1 Hbegf Gab1 Pik3r1 Casp3 Jun Arhgef1 Egfr Adra1b Ptk2b Gna13 Mmp9 Gna12 Ptk2 Lyn Gna14 Adcy6 Gnai1 Gng2 Adcy7 Gna15 BIOCARTA_RARRXR_PATHWAY%MSIGDB_C2%BIOCARTA_RARRXR_PATHWAY BIOCARTA_RARRXR_PATHWAY Kat2b Gtf2e1 Gtf2a1 Ncoa2 Ercc3 Ncoa3 Ncoa1 Hdac3 Polr2a Tbp Rxra Gtf2b Gtf2f1 Ncor2 Rara PID_S1P_S1P2_PATHWAY%MSIGDB_C2%PID_S1P_S1P2_PATHWAY PID_S1P_S1P2_PATHWAY Cdh5 Gnai2 Gnaq S1pr2 Mapk8 Pak1 Gna11 Gnai3 Rhoa Gnao1 Jun Mapk14 Elk1 Gnaz Gna13 Gna12 Gna14 Irs1 Gnai1 Mapk1 Mapk3 Fos Gna15 Rac1 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES%MSIGDB_C2%SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Sos1 Brd4 Gsk3b Pard3 Cdkn2a Ywhaz Gsk3a Igfbp1 Slc2a4 Cyth3 Rps6ka1 Shc1 Npy4r Flot1 Ptpn1 Pik3ca F2rl2 Flot2 Sfn Foxo1 Irs2 Akt3 Irs4 Pard6a Akt1 Pdk1 Pik3r1 Rps6ka3 Ywhae Sorbs1 Akt2 Grb2 Pik3cd Pten Ywhab Rps6ka2 Irs1 Cap1 Mapk1 Mapk3 Serpinb6a Ywhah Cbl Ywhag Lnpep Inppl1 Sos2 Raf1 BIOCARTA_RELA_PATHWAY%MSIGDB_C2%BIOCARTA_RELA_PATHWAY BIOCARTA_RELA_PATHWAY Tnfrsf1a Tnfrsf1b Crebbp Ikbkb Ep300 Hdac3 Fadd Traf6 Tradd Nfkbia Ikbkg Ripk1 Rela Nfkb1 Chuk Tnf PID_VEGFR1_2_PATHWAY%MSIGDB_C2%PID_VEGFR1_2_PATHWAY PID_VEGFR1_2_PATHWAY Vtn Cdh5 Prkab1 Hsp90ab1 Prkag1 Camkk2 Dnm2 Prkca Prkaa1 Prkaa2 Map2k1 Map2k2 Mapk14 Pdpk1 Shb Braf Pxn Prkaca Fes Iqgap1 Nos3 Mapk11 Akt1 Ctnna1 Ptprj Grb10 Ptpn11 Rhoa Fbxw11 Vcl Akap1 Nedd4 Kdr Hsp90aa1 Hgs Cav1 Mapk1 Vegfa Mapk3 Flt1 Raf1 Rock1 Ctnnb1 Src Itgb3 Prkcd Plcg1 Map2k6 Pik3ca Gab1 Ptpn2 Nck2 Sh2d2a Arf1 Map2k3 Ptpn6 Pik3r1 Nck1 Pak2 Myof Fyn Grb2 Prkcb Ptk2b Ptk2 Itgav Mapkapk2 Cbl BIOCARTA_ACTINY_PATHWAY%MSIGDB_C2%BIOCARTA_ACTINY_PATHWAY BIOCARTA_ACTINY_PATHWAY Wasl Abi2 Acta1 Nckap1 Nck1 Wasf3 Wasf1 Pir Arpc5 Arpc1a Ntrk1 Wasf2 Arpc2 Psma7 Arpc3 Arpc4 Actr3 Actr2 Rac1 Arpc1b BIOCARTA_LONGEVITY_PATHWAY%MSIGDB_C2%BIOCARTA_LONGEVITY_PATHWAY BIOCARTA_LONGEVITY_PATHWAY Igf1r Igf1 Akt1 Sod2 Cat Pik3r1 Ghr Foxo3 Shc1 Pik3cg Hras Sod3 Pik3ca PID_WNT_CANONICAL_PATHWAY%MSIGDB_C2%PID_WNT_CANONICAL_PATHWAY PID_WNT_CANONICAL_PATHWAY Apc Axin1 Gsk3b Csnk1g1 Dvl1 Dvl3 Pip5k1b Gsk3a Fzd5 Wnt3a Ppp2r5a Ctnnb1 Cul3 Cav1 Klhl12 Nkd2 Dvl2 Ranbp3 Lrp6 Pi4k2a SA_B_CELL_RECEPTOR_COMPLEXES%MSIGDB_C2%SA_B_CELL_RECEPTOR_COMPLEXES SA_B_CELL_RECEPTOR_COMPLEXES Sos1 Rps6ka3 Vav1 Grb2 Rps6ka1 Vav3 Shc1 Map2k1 Atf2 Jun Elk1 Pappa Hras Map3k1 Lyn Mapk8ip3 Mapk1 Mapk3 Fos Blnk Syk Bcr Rac1 Vav2 PID_INTEGRIN_A9B1_PATHWAY%MSIGDB_C2%PID_INTEGRIN_A9B1_PATHWAY PID_INTEGRIN_A9B1_PATHWAY Csf2 F13a1 Vcam1 Adam12 Src Vegfc Csf2ra Pxn Sat1 Itgb1 Tnc Bcar1 Adam8 Adam2 Tgm2 Fn1 Adam15 Paox Itga9 Vegfa Figf Nos2 Spp1 Kcnj15 Rac1 BIOCARTA_SET_PATHWAY%MSIGDB_C2%BIOCARTA_SET_PATHWAY BIOCARTA_SET_PATHWAY Crebbp Prf1 Gzmb Nme1 Dffa Dffb Hmgb2 Gzma Apex1 Anp32a PID_PI3KCI_PATHWAY%MSIGDB_C2%PID_PI3KCI_PATHWAY PID_PI3KCI_PATHWAY Adap1 Cyth3 Dapp1 Pdpk1 Hras Syk Rap1a Inpp5d Foxo3 Pik3cb Rhoa Pten Hsp90aa1 Sgk1 Nras Inppl1 Pik3r5 Rac1 Pik3r6 Cyth1 Yes1 Src Arf6 Plcg1 Pik3ca Blk Plekha1 Arf5 Plekha2 Btk Plcg2 Arf1 Pik3r3 Lat Pik3r1 Cyth2 Hck Lck Pik3r2 Kras Fyn Zap70 Arap3 Pik3cd Itk Pik3cg Fgr Lyn Blnk BIOCARTA_ASBCELL_PATHWAY%MSIGDB_C2%BIOCARTA_ASBCELL_PATHWAY BIOCARTA_ASBCELL_PATHWAY Fas Il2 Cd40 Cd4 Fasl Cd80 Il10 H2-Eb1 Cd40lg Il4 NABA_ECM_AFFILIATED%MSIGDB_C2%NABA_ECM_AFFILIATED NABA_ECM_AFFILIATED Plxdc2 Anxa11 Parm1 Plxdc1 Cd209d Lman1 Reg2 Clec1b Clec1a Reg4 Lgals2 Clec11a Clec10a Muc13 Lgals9 Anxa10 Muc15 Lgals4 Clec4e Clec4g Clec4d Elfn1 Clec4n Muc4 Clec4f Gpc6 Gpc2 Anxa2 Elfn2 Gpc5 Clec2l Clec3b Clec3a Muc20 Anxa3 Sdc2 Plxna2 Sdc3 Plxna1 Plxna4 Lgals7 Sdc4 Plxna3 Fcnb Sema7a Anxa8 C1qc Anxa6 Anxa7 C1ql3 C1ql4 C1ql1 C1ql2 C1qa Sema6a C1qb Sema6c Clec4a2 Itln1 Lgals8 Clec18a Lgalsl Sftpb Sftpc Clec12a Clec12b Cspg5 Lman1l Plxnc1 Cspg4 Lgals12 Plxnd1 Clec14a Plxnb3 Sdc1 Reg1 Plxnb1 Muc1 Sftpd Clec5a Anxa9 Sftpa1 Anxa1 Lgals1 Sema4d Grem1 Mbl2 Gpc3 Gpc4 Sema3c Plxnb2 Cd209a Lgals3 Anxa4 Gpc1 Frem2 Frem1 Sema4g Sema4f Sema4c Sema4b Sema4a Clec4b2 Sema6b Sema6d Reg3b Reg3g Sema5b Sema5a Emcn Frem3 Sema3b C1qtnf9 Clec9a Anxa5 C1qtnf2 C1qtnf1 Hpx C1qtnf7 Ovgp1 Clec7a Colec12 Colec11 Sema3f Sema3g Sema3e Colec10 Sema3a Sema3d PID_WNT_SIGNALING_PATHWAY%MSIGDB_C2%PID_WNT_SIGNALING_PATHWAY PID_WNT_SIGNALING_PATHWAY Fzd7 Fzd1 Wnt1 Cthrc1 Rspo1 Fzd5 Wnt3a Igfbp4 Lrp5 Lrp6 Wnt7b Wnt7a Fzd8 Ror2 Fzd2 Fzd6 Ryk Fzd9 Kremen2 Kremen1 Atp6ap2 Fzd10 Wnt3 Fzd4 Dkk1 Wnt2 Wnt5a Wif1 PID_RETINOIC_ACID_PATHWAY%MSIGDB_C2%PID_RETINOIC_ACID_PATHWAY PID_RETINOIC_ACID_PATHWAY Kat2b Crebbp Vdr Ncoa2 Ep300 Ncoa3 Prkca Mapk14 Cdk7 Ncor2 Prkaca Cdk1 Rbp1 Hdac1 Akt1 Nrip1 Ccnh Mapk8 Ncoa1 Rxrg Hdac3 Prkcg Rarb Rarg Rxra Mnat1 Mapk1 Rara Mapk3 Rxrb NABA_MATRISOME%MSIGDB_C2%NABA_MATRISOME NABA_MATRISOME Reln C1qc C1qa C1qb Cxcl11 Cxcl10 Csf1 Cxcl13 Ebi3 Ltb Elane Inhbe Cxcl3 Cxcl9 Cxcl2 Pf4 A2m Col1a2 Ccl7 Il7 Pdgfc Plau Kitl Serpine1 Lep Il2 Fasl Sftpa1 Tgfb1 Il1b Il6 Igf1 Il5 Ccl11 Il4 Tnfsf11 Ins2 Bmp6 Ibsp Plxdc2 Col19a1 Anxa11 Zp3 Parm1 Zp2 Plxdc1 Cd209d Ecm1 Vwa3a Reg2 Tinag Clec1b Oit3 Clec1a Rspo2 Reg4 Rspo1 Lgals2 Lamc3 Clec11a Ecm2 Clec10a Muc13 Creld1 Lgals9 Creld2 Pcolce Muc15 Rspo3 Lgals4 Clec4e Lamc2 Igfbp6 Clec4g Clec4d Rspo4 Lamc1 Elfn1 Tsku Clec4n Fgl1 Muc4 Egf Tnn Fbn1 Clec4f Fras1 Gpc6 Adam17 Gpc2 Tnr Elfn2 Fgl2 Col16a1 Gpc5 Esm1 Clec2l Clec3b Tnc Otog Clec3a Thsd4 Muc20 Anxa3 Col22a1 Lum Plxna2 Tnfaip6 Plxna1 Plxna4 Gldn Plxna3 Col11a1 Gas6 Fcnb Sema7a Col11a2 Anxa8 Chad Anxa6 Omd Anxa7 Papln Fbn2 C1ql3 Col12a1 C1ql4 Colq C1ql1 Tinagl1 C1ql2 Fndc1 Sema6a Prg2 Sema6c Prg3 Itln1 Ltbp1 Lgals8 Bsph1 Clec18a Crim1 Lgalsl Ltbp4 Sftpb Ltbp2 Sftpc Ltbp3 Clec12a Tectb Clec12b Egflam Cspg5 Col26a1 Tgfb3 Lman1l Tnxb Plxnc1 Fndc8 Cspg4 Fndc7 Lgals12 Wisp1 Plxnd1 Ctgf Npnt Clec14a Plxnb3 Vwa5b2 Col20a1 Col24a1 Ogn Vwce Smoc2 Mepe Egln2 Igfbpl1 Smoc1 Rangap1 Podnl1 Kera Pxdn Hspg2 Col10a1 Nell2 Nell1 Ntng1 Emilin1 Emilin3 Lrg1 Pcolce2 Emilin2 Dmbt1 Col28a1 Igfbp5 Col8a2 Efemp2 Ddx26b Zpld1 Efemp1 Vwde Cilp Col9a1 Col9a2 Col5a3 Epo Col5a2 Vwa5a Col8a1 Prelp Col9a3 Mfap5 Mfap4 Mfap2 Ntn1 Otol1 Nyx Ntn4 Ntn5 Thbs2 Thbs1 Igfals Mfge8 Mfap3 Thbs4 Optc Thbs3 Lamb3 Sparcl1 Zp1 Lamb1 Edil3 Spp1 Cdcp2 Lamb2 Bmp2 Hyal3 Hyal1 Pappa Kazald1 Htra4 Serpinb3a Serpinb3d Hyal2 Angpt2 Tgm4 Tgm5 Mmp2 Angpt4 Htra3 Angpt1 Tgm6 Adamdec1 Tgm3 Plg F2 Fgf2 Fn1 Fst Chrd Grem1 Bmp4 Bmp7 Mmp23 Col23a1 Matn1 Plod2 Col7a1 Mmp25 Nrg1 Mmp24 Emid1 Dpt P3h3 Col6a6 Fam20c Coch Cstl1 Col6a1 Fam20b Col5a1 Adamts7 Cthrc1 Mmp17 Sbspon Slit1 Adamts8 Comp Adamts6 Sned1 F13a1 Mmp16 Slit3 Shh Plod1 Vwa5b1 Plod3 Tecta Mmp21 Crispld1 Col25a1 Igfbp3 Sulf1 Crispld2 Mmp20 Amelx Adam30 Hapln2 Adam32 Eln Adam33 Tll1 Hapln1 Hapln4 Adamts13 Mmp27 Hapln3 Nid1 P3h2 Nid2 Fam20a Mmp28 Matn3 Matn2 P3h1 Vit 2010005H15Rik Mep1b Matn4 Fmod Sulf2 Serpinb10 Spon1 Serpina12 Spon2 Serpina11 Nov Postn Pcsk6 Serpinb13 Mmrn2 Vwa1 Serpinb12 Vwa2 Serpinb11 Dspp Egln3 Cst7 Spock2 Cst6 Mmrn1 Vwa7 Hyal5 Hyal4 Spock1 Pcsk5 Tbc1d24 Col27a1 Cst9 Vwa9 Cst8 Ctsa Spock3 Cela1 Timp1 Adamts3 Ctsf Ctsc Adamts4 Hpse Adamts2 Mmp19 St14 Ctsz Cst3 Pappa2 Astl Cstb Kcp Ctsw Ngf Serpinb1a Adam18 Csf2 Adam19 Ky Ambp Adam11 Adam10 Cst11 Adamts20 Cst10 Serpind1 Itih5 Cela3b Itih2 Cpn2 Serpinb7 Serpinb9 Prss12 Osm Col2a1 Adam29 Adamts14 Adam28 Adamts15 Tll2 Adamts16 Adamts18 Adamts19 Pamr1 Slpi Hpse2 Adam21 Adam22 Adamts10 Ccl12 Adamts12 P4ha3 Serpina10 Adam8 Adam7 Lgals7 Serpini2 Tgfb2 Ogfod2 Tmprss15 Serpinh1 Ntf3 Adam2 Habp2 Serpinf2 Serpina3n Ogfod1 F7 Loxl4 Loxl3 Serpinf1 Timp4 Adamtsl1 Tgm1 Serpinb8 Prss2 Adamtsl3 Adamtsl4 Adamtsl2 Timp2 Serpina7 Serpina5 Adamtsl5 Serpina9 Serpinb6a Serpini1 Cela2a Cd109 Wnt16 Serpinb2 P4htm Itih3 Loxl1 Loxl2 Serpine3 Serpine2 Fgf22 Ambn Insl5 Fgf16 Bmper Col13a1 Svep1 Abi3bp Ndnf Aspn Col14a1 Csf3 Lgi4 Il1a Pdgfa Lama4 Lgi3 Fbln7 Lgi2 Col17a1 Lgi1 Impg2 Lama5 Dmp1 Impg1 Col4a4 Srpx2 Fbln5 Col4a2 Igsf10 Col4a3 Fbln2 Podn Col4a1 Cilp2 Epyc Mfap1b Vwf Adipoq Ush2a Tnf Tnfsf13b Vegfa Tnfsf13 Kng2 Il17a Frem2 Frem1 Sema4g Sema4f Sema4c Sema4b Sema4a Clec4b2 Sema6b Sema6d Col4a5 Reg3b Reg3g Sema5b Col4a6 Sema5a Emcn Frem3 C1qtnf9 Clec9a C1qtnf2 C1qtnf1 Hpx C1qtnf7 Ovgp1 Clec7a Colec12 Colec11 Sema3f Sema3g Sema3e Colec10 Sema3a Sema3d Sspo Wnt1 Serpinb5 Tnfsf10 Ifnb1 Hgfac Reg1 Hrg Muc1 Igfbp1 Anxa9 Igfbp4 Itih4 Ccl25 Itih1 Col6a3 Col6a2 Col3a1 Mbl2 Angptl3 Sparc Igfbp7 Plxnb2 Adam12 Agrn Col15a1 Aebp1 F10 Fbln1 Lama2 Col1a1 Adamts1 Lman1 Ctse Ctsb P4ha2 Wnt9b Wnt9a Nrg3 Nrg4 Megf8 Ereg S100g Gdf9 S100z Gdf5 S100b Megf9 Gdf2 Gdf3 Gdf6 Gdf7 Ism2 Wnt8a Tpo Wnt8b Tnfsf12 Tnfsf15 Tnfsf14 Ism1 Nodal Bdnf Fgf18 Tnfsf18 Wnt7b Fgf17 Fgf14 Fgf15 Fgf11 Wnt7a Fgf10 Fgf13 Fgf12 Insl6 Vwc2l Angptl7 Angptl6 Tchhl1 Angptl2 Angptl1 Insl3 Pik3ip1 Fgf23 Mdk Fgf20 Fgf21 Il17b Ptn Il17d Il17c Flt3l Il17f Ccl22 Ccl28 Tnfsf4 Ccl24 Lefty2 Ccl20 Tnfsf8 Frzb Il1f5 Il1f6 Il24 Il20 Il25 Cd209a Il1f8 Il1f9 Cxcl14 Ctf1 Fgfbp1 Fgfbp3 Vegfb Vegfc Fgf1 Fgf3 Anxa4 Fgf5 Fgf6 Fgf7 Fgf8 Fgf9 Il34 Gpc1 Megf6 Cbln1 Ntf5 Cbln2 Bmp3 Slit2 Bmp5 Lama1 Wfikkn2 Serpinc1 Wfikkn1 Vwc2 Areg Amh Il11 Cbln3 Cbln4 Brinp2 Il19 Nrtn Artn Zfp91 Adam15 Nrg2 Crhbp Brinp3 Flg2 Il1rn Adam23 Bmp8a Eda Rptn Figf Ifne Ifnk Adamts5 Megf10 Megf11 Srgn Prl Anxa10 Ctsd Mmp1a Lama3 Col18a1 Mgp Dcn Lif Clec4a2 Sdc1 Ctss Mep1a F12 Serping1 Ctsh Ctsl Ctsk Ctso Adam9 Mmp10 Mmp15 F13b Mmp11 Mmp14 Timp3 Serpina1d Serpina1a Clec5a Bmp1 Mmp8 Masp2 Htra1 Anxa1 Mmp7 Lgals1 Sema4d Serpina6 Il9 Ifna16 Lta Sema3c Il10 Il16 Il15 Il13 Cyr61 Ngly1 Vcan Fgf4 Srpx Wisp2 Inha Pgf F9 Anxa2 Angptl4 Bgn Sdc2 Sdc3 Sdc4 Gdnf Lox Igfbp2 Tgm2 Tgfbi Fga Fgb Fgg Mmp3 Pdgfd Ctsg Mmp9 Vtn Mmp13 Mmp12 Hgf Gpc3 Gpc4 S100a4 Ncan Bcan Pdgfb Ccl4 P4ha1 Cxcl12 Clcf1 Chrdl2 Scube3 Wnt5b Wnt5a S100a9 S100a8 Crnn Scube1 S100a5 S100a3 Wif1 S100a6 Epgn Cxcl5 Xcl1 Mstn Cxcl1 S100a1 Tchh Cx3cl1 Gdf15 Iltifb Gdf10 Cntf Tgfa Hhip Btc Wnt3a Ifng Sfrp5 Il12b Bmp15 Wnt2b Plxnb1 Il1f10 Gdf11 Sfrp1 Sfrp2 Il12a Sfrp4 Egfl6 Egfl7 Crlf3 Crlf1 Bmp10 Hbegf Egfl8 Il18 Thpo Wnt10b Wnt10a Ccl1 Dhh Il23a Mst1 Hcfc2 Hcfc1 S100a14 Inhbc S100a13 Pspn Lefty1 Ccl5 Ccl2 Ccl3 Wnt3 Agt Wnt11 S100a16 Wnt2 Inhbb S100a10 Inhba Ccbe1 Fstl3 Fstl1 Wnt6 Sftpd Igf2 Ppbp Ihh Ccl17 Wnt4 Plat S100a11 Lgals3 Sema3b Anxa5 BIOCARTA_IL17_PATHWAY%MSIGDB_C2%BIOCARTA_IL17_PATHWAY BIOCARTA_IL17_PATHWAY Cd4 Il17a Il6 Cd247 Cd3d Cd2 Csf3 Kitl Cd34 Cd3g Cd3e Cd8a BIOCARTA_IL7_PATHWAY%MSIGDB_C2%BIOCARTA_IL7_PATHWAY BIOCARTA_IL7_PATHWAY Il2rg Jak1 Jak3 Crebbp Il7 Pik3r1 Bcl2 Ep300 Lck Fyn Pik3cg Nmi Stat5b Stat5a Ptk2b Il7r Pik3ca BIOCARTA_NO2IL12_PATHWAY%MSIGDB_C2%BIOCARTA_NO2IL12_PATHWAY BIOCARTA_NO2IL12_PATHWAY Cd4 Cd2 Cxcr3 Ifng Il12b Cd247 Cd3d Ccr5 Stat4 Tyk2 Il12a Il12rb2 Cd3g Nos2 Cd3e Jak2 Il12rb1 BIOCARTA_ATM_PATHWAY%MSIGDB_C2%BIOCARTA_ATM_PATHWAY BIOCARTA_ATM_PATHWAY Chek1 Rad51 Mre11a Mdm2 Trp73 Gadd45a Chek2 Atm Mapk8 Rad50 Cdkn1a Jun Nfkbia Rbbp8 Nbn Rela Trp53 Nfkb1 Brca1 Abl1 BIOCARTA_NKT_PATHWAY%MSIGDB_C2%BIOCARTA_NKT_PATHWAY BIOCARTA_NKT_PATHWAY Csf2 Cd4 Ccr3 Il5 Il4ra Cd40lg Il4 Ifng Ccr7 Il12b Il2 Ccr5 Il12a Ifngr1 Il12rb2 Ifngr2 Il18r1 Cxcr4 Il12rb1 Ccr1 Tgfb2 Cxcr3 Ccr2 Tgfb1 Ccl4 Ccr4 Tgfb3 PID_THROMBIN_PAR4_PATHWAY%MSIGDB_C2%PID_THROMBIN_PAR4_PATHWAY PID_THROMBIN_PAR4_PATHWAY Rock1 F2 Gnaq Myl2 Gna11 F2rl3 Gnb1 Rhoa Gna13 Gna14 F2rl2 Gng2 Rock2 Gna15 Plcb2 BIOCARTA_MCM_PATHWAY%MSIGDB_C2%BIOCARTA_MCM_PATHWAY BIOCARTA_MCM_PATHWAY Orc1 Mcm7 Orc2 Ccne1 Mcm3 Mcm2 Cdt1 Orc3 Mcm4 Orc4 Mcm5 Kitl Mcm6 Cdkn1b Cdk2 Orc6 Orc5 Cdc6 BIOCARTA_MITOCHONDRIA_PATHWAY%MSIGDB_C2%BIOCARTA_MITOCHONDRIA_PATHWAY BIOCARTA_MITOCHONDRIA_PATHWAY Apaf1 Dffa Bcl2 Xiap Dffb Bax Diablo Birc2 Bid Casp6 Birc3 Casp7 Casp3 Casp9 Bcl2l1 Aifm1 Bak1 Endog Casp8 Bik HALLMARK_MYC_TARGETS_V2%MSIGDB_C2%HALLMARK_MYC_TARGETS_V2 HALLMARK_MYC_TARGETS_V2 Srm Rcl1 Ddx18 Exosc5 Slc19a1 Phb Prmt3 Plk1 Plk4 Tmem97 Nop56 Nolc1 Hk2 Dctpp1 Ndufaf4 Wdr74 Ipo4 Ppan Rabepk Wdr43 Tbrg4 Pes1 Pprc1 Utp20 Noc4l Ung Las1l Bysl Mphosph10 Imp4 Tfb2m Nip7 Farsa Supv3l1 Grwd1 Mrto4 Tcof1 Dusp2 Mybbp1a Mcm4 Slc29a2 Pus1 Hspd1 Rrp9 Myc Nop16 Nop2 Cdk4 Gnl3 Aimp2 Rrp12 Npm1 Map3k6 Mcm5 Cbx3 Pa2g4 Sord HALLMARK_P53_PATHWAY%MSIGDB_C2%HALLMARK_P53_PATHWAY HALLMARK_P53_PATHWAY Traf4 Plk2 Aen Ip6k2 Dram1 Nupr1 Trafd1 Clca2 Hist1h1c Cdkn2aip Zmat3 Zbtb16 Dnttip2 Rnf19b Atf3 Sat1 Fos Ier5 Cd81 Btg1 Plk3 Ndrg1 Foxo3 Rap2b Vamp8 Klk8 Ccnd3 Cdkn2a Ralgds Apaf1 Txnip Slc7a11 Bak1 Btg2 Ada Rb1 Acvr1b Adck3 Cebpa Ifi30 Procr Cdkn1a Tspyl2 Sp1 Def6 Prkab1 Il1a Pdgfa Fgf13 Tnni1 Cdk5r1 Hspa4l Cyfip2 Sphk1 Rxra Tgfb1 Alox8 Irak1 Fam162a Mknk2 S100a4 Triap1 Steap3 Epha2 Rps27l Rad9a Ccnk Sesn1 Ier3 Gadd45a Rpl18 App Stom Ddit3 Jun Socs1 Fdxr Mapkapk3 H2afj Csrnp2 Sec61a1 Prmt2 Ldhb Ei24 Osgin1 Sertad3 Wrap73 Nol8 Tm7sf3 Nudt15 Lrmp Serpinb5 Zfp365 Hexim1 Rad51c Tm4sf1 Pcna Tprkb Ccp110 Fuca1 Hist3h2a Cd82 Dgka Ptpn14 Pitpnc1 Hras Ctsd Notch1 Gm2a Ddit4 Tcn2 Nhlh2 Slc3a2 Cgrrf1 Itgb4 Blcap Ankra2 Hmox1 Phlda3 Sfn Rrp8 Rhbdf2 Gls2 Pom121 Slc19a2 Wwp1 Lif Ddb2 Eps8l2 Abhd4 Rab40c Hint1 Hdac3 Mxd1 Tob1 Ppp1r15a Xpc Sdc1 Tchh Tgfa Slc35d1 Dcxr Abat Hbegf F2r Tap1 Baiap2 Vwa5a Iscu Bax Inhbb S100a10 Kif13b Bmp2 Casp1 Fas Rchy1 Ccng1 Trp53 Ppm1d Ninj1 Ikbkap Jag2 Upp1 Pidd1 Rgs16 Cdh13 Vdr Polh Rrad Perp Mxd4 Plxnb2 Abcc5 Gpx2 Zfp36l1 Ercc5 Gnb2l1 Ak1 Fbxw7 Trp63 Tpd52l1 Ccnd2 Mdm2 Retsat Cdkn2b Pmm1 Ctsf Klf4 Trib3 Ephx1 Krt17 Tsc22d1 St14 Ptpre BIOCARTA_PARKIN_PATHWAY%MSIGDB_C2%BIOCARTA_PARKIN_PATHWAY BIOCARTA_PARKIN_PATHWAY Park2 Ube2f Sept5 Ube2e2 Gpr37 Ube2l3 Ube2l6 Snca Ube2g2 Ube2g1 Sncaip BIOCARTA_ATRBRCA_PATHWAY%MSIGDB_C2%BIOCARTA_ATRBRCA_PATHWAY BIOCARTA_ATRBRCA_PATHWAY Chek1 Rad51 Mre11a Chek2 Atm Rad50 Rad1 Brca2 Fancd2 Nbn Rad17 Trex1 Trp53 Fancc Rad9a Brca1 Fancg Hus1 Fancf ST_G_ALPHA_I_PATHWAY%MSIGDB_C2%ST_G_ALPHA_I_PATHWAY ST_G_ALPHA_I_PATHWAY Sos1 Plcb3 Shc1 Src Terf2ip Ephb2 Braf Drd2 Plcb4 Rgs20 Cfb Akt3 Akt1 Pik3cb Stat3 Akt2 Grb2 Itpr3 Egfr Kcnj3 Asah1 Dag1 Pitx2 Mapk1 Itpkb Kcnj5 Plcb1 Itpr1 Itpka Sos2 Raf1 Itpr2 Plcb2 Kcnj9 BIOCARTA_EPO_PATHWAY%MSIGDB_C2%BIOCARTA_EPO_PATHWAY BIOCARTA_EPO_PATHWAY Sos1 Epo Ptpn6 Mapk8 Epor Grb2 Shc1 Map2k1 Jun Elk1 Stat5b Stat5a Hras Plcg1 Mapk3 Fos Jak2 Raf1 BIOCARTA_IGF1_PATHWAY%MSIGDB_C2%BIOCARTA_IGF1_PATHWAY BIOCARTA_IGF1_PATHWAY Sos1 Igf1r Igf1 Pik3r1 Mapk8 Ptpn11 Grb2 Shc1 Map2k1 Jun Pik3cg Rasa1 Elk1 Hras Srf Pik3ca Irs1 Mapk3 Fos Raf1 BIOCARTA_EIF2_PATHWAY%MSIGDB_C2%BIOCARTA_EIF2_PATHWAY BIOCARTA_EIF2_PATHWAY Gsk3b Eif2s3x Eif2ak2 Ppp1ca Eif5 Eif2ak3 Eif2b5 Eif2s1 Eif2s2 Eif2ak4 Eif2ak1 PID_IL2_STAT5_PATHWAY%MSIGDB_C2%PID_IL2_STAT5_PATHWAY PID_IL2_STAT5_PATHWAY Ccna2 Sos1 Il2rg Jak1 Ccnd3 Jak3 Prf1 Lta Il4 Shc1 Il2ra Bcl2l1 Cdk6 Il2 Fasl Stat5b Stat5a Gab2 Pik3ca Myc Foxp3 Ccnd2 Elf1 Bcl2 Pik3r1 Lck Ptpn11 Grb2 Sp1 Il2rb PID_PLK1_PATHWAY%MSIGDB_C2%PID_PLK1_PATHWAY PID_PLK1_PATHWAY Fbxo5 Cdc25c Clspn Sspo Cdc25b Cenpe Pak1 Kiz Ppp1cb Bora Cdc14b Stag2 Ect2 Cenpu Bub1b Plk1 Cdc20 Rock2 Cdk1 Tpx2 Prc1 Kif2a Aurka Gorasp1 Tubg1 Sgol1 Ppp1r12a Rhoa Nudc Bub1 Fbxw11 Golga2 Ninl Fzr1 Spc24 Ercc6l Ppp2ca Incenp Ppp2r1a Wee1 Kif20a Rab1 Ndc80 BIOCARTA_CARM_ER_PATHWAY%MSIGDB_C2%BIOCARTA_CARM_ER_PATHWAY BIOCARTA_CARM_ER_PATHWAY Sra1 Crebbp Hdac2 Hdac5 Gtf2e1 Gtf2a1 Ep300 Phb2 Hdac4 Hdac9 Ncor2 Spen Ccnd1 Hdac6 Hdac7 Hdac1 Nrip1 Ercc3 Carm1 Hdac8 Nr0b1 Hdac3 Polr2a Tbp Grip1 Hist2h3c1 Ppargc1a Hdac11 Gtf2f1 Hdac10 Esr1 Brca1 Med1 Mef2c Pelp1 BIOCARTA_INFLAM_PATHWAY%MSIGDB_C2%BIOCARTA_INFLAM_PATHWAY BIOCARTA_INFLAM_PATHWAY Csf2 Cd4 Il6 Ifnb1 Csf3 Il1a Pdgfa Ifna16 Csf1 Lta Il5 Il10 H2-Eb1 Il15 Il13 Il4 Ifng Il2 Il12b Il12a Tnf Tgfb2 Il7 Il11 Tgfb1 Tgfb3 BIOCARTA_IL3_PATHWAY%MSIGDB_C2%BIOCARTA_IL3_PATHWAY BIOCARTA_IL3_PATHWAY Sos1 Ptpn6 Il3ra Grb2 Map2k1 Shc1 Stat5b Stat5a Hras Csf2rb2 Mapk3 Fos Jak2 Raf1 PID_NETRIN_PATHWAY%MSIGDB_C2%PID_NETRIN_PATHWAY PID_NETRIN_PATHWAY Camk2a Dapk1 Pak1 Elmo1 Map2k1 Map2k2 Yes1 Src Agap2 Pitpna Unc5b Unc5a Plcg1 Pik3ca Myo10 Bcar1 Wasl Dcc Trio Map1b Pik3r1 Nck1 Ntn1 Fyn Rhoa Ptk2 Unc5c Dock1 Mapk1 Mapk3 Rac1 BIOCARTA_PROTEASOME_PATHWAY%MSIGDB_C2%BIOCARTA_PROTEASOME_PATHWAY BIOCARTA_PROTEASOME_PATHWAY Psmd14 Rpn1 Psmd8 Psmb2 Psmb3 Psma7 Uba1 Psmc6 Ube2a Psmc4 Psmd11 Psmc2 Psma5 Psmb5 Psmb4 Rpn2 Psmd12 Psmb1 Psmd6 Psmb7 Psmb6 Psmc3 Psma1 Psma2 Psma6 Ube3a Psma4 Psma3 BIOCARTA_LECTIN_PATHWAY%MSIGDB_C2%BIOCARTA_LECTIN_PATHWAY BIOCARTA_LECTIN_PATHWAY C2 C7 Mbl2 C6 C3 C8a Masp2 C9 Hc BIOCARTA_HCMV_PATHWAY%MSIGDB_C2%BIOCARTA_HCMV_PATHWAY BIOCARTA_HCMV_PATHWAY Akt1 Creb1 Map2k3 Pik3r1 Map2k1 Pik3cg Map2k2 Mapk14 Sp1 Map3k1 Rela Rb1 Map2k6 Nfkb1 Pik3ca Mapk1 Mapk3 BIOCARTA_ECM_PATHWAY%MSIGDB_C2%BIOCARTA_ECM_PATHWAY BIOCARTA_ECM_PATHWAY Tln1 Rock1 Gsn Pik3r1 Myl2 Mylk Fyn Arhgap5 Rhoa Shc1 Map2k1 Pfn1 Pik3cg Diap1 Hras Src Ptk2 Pik3ca Mapk1 Pxn Mapk3 Itgb1 Raf1 Itga1 HALLMARK_UV_RESPONSE_DN%MSIGDB_C2%HALLMARK_UV_RESPONSE_DN HALLMARK_UV_RESPONSE_DN Tfpi Notch2 Ppap2b Amph Prkca Ptpn21 Inpp4b Lamc1 Gcnt1 Ptgfr Fhl2 Anxa2 Zmiz1 Id1 Mta1 Sdc2 Gja1 Tgfbr3 Col11a1 Add3 Map1b Sri Ltbp1 Pten Acvr2a Smad7 Erbb2 Irs1 Nek7 Dab2 Tgfbr2 Pmp22 Prkce Bckdhb Atrx Itgb3 Mt1 Igfbp5 Adora2b Plcb4 Atp2b4 Synj2 Myc Efemp1 Cdc42bpa Nr3c1 Col1a2 Papd7 Dlc1 Col5a2 Kit Pias3 Arhgef9 Atp2b1 Slc7a1 Serpine1 Vldlr Mgll Prkar2b Pdgfrb Kalrn Cap2 Mapk14 Fbln5 Pex14 Bdnf Pdlim5 Rgs4 Atp2c1 Akt3 Atxn1 Schip1 Fzd2 Dusp1 Dlg1 Smad3 Abcc1 Ythdc1 Cited2 Rxra Cav1 Col3a1 Nfkb1 Cdkn1b Bmpr1a Vav2 Lpar1 Rnd3 Aggf1 Igf1r Kcnma1 Nrp1 Nipbl Wdr37 F3 Sfmbt1 Sipa1l1 Cdk13 Dyrk1a Syne1 Ddah1 Mrps31 Mmp16 Fam179b Magi2 Spop Met Phf3 Atrn Has2 Mgmt Prdm2 Atp5s Cacna1a Ptprm Mios Scn8a Anxa4 Grk5 Nr1d2 Celf2 Adgrl2 Ica1 Dbp Apbb2 Cyr61 Cdon Pik3r3 Tjp1 Pparg Bhlhe40 Fyn Pik3cd Rasa2 Map2k5 Insig1 Col1a1 Snai2 Ldlr Slc22a18 BIOCARTA_TGFB_PATHWAY%MSIGDB_C2%BIOCARTA_TGFB_PATHWAY BIOCARTA_TGFB_PATHWAY Apc Tgfb2 Crebbp Ep300 Smad3 Map2k1 Smad4 Zfyve9 Smad2 Cdh1 Tgfb1 Smad7 Skil Tab1 Tgfb3 Mapk3 Map3k7 Tgfbr2 Tgfbr1 BIOCARTA_AGR_PATHWAY%MSIGDB_C2%BIOCARTA_AGR_PATHWAY BIOCARTA_AGR_PATHWAY Pak6 Pak7 Pak3 Nrg3 Nrg1 Pak4 Utrn Acta1 Dvl1 Lama4 Pak1 Rapsn Dmd Musk Src Git2 Lama3 Pxn Itgb1 Chrna1 Pak2 Mapk8 Lama2 Jun Nrg2 Egfr Sp1 Dag1 Ptk2 Chrm1 Mapk1 Mapk3 Cttn Itga1 Rac1 BIOCARTA_GATA3_PATHWAY%MSIGDB_C2%BIOCARTA_GATA3_PATHWAY BIOCARTA_GATA3_PATHWAY Prkar2a Prkar2b Map2k3 Il5 Il4 Il13 Prkar1b Mapk14 Prkar1a Junb Nfatc1 Gata3 Nfatc2 Prkacb Maf PID_P38_MKK3_6PATHWAY%MSIGDB_C2%PID_P38_MKK3_6PATHWAY PID_P38_MKK3_6PATHWAY Tab2 Atm Txn1 Camk2b Mapk14 Map3k3 Map2k6 Map3k5 Mapk11 Ccm2 Gadd45a Map2k3 Gadd45g Traf2 Traf6 Map3k4 Gadd45b Map3k1 Map3k6 Taok3 Taok1 Tab1 Map3k10 Map3k7 Rac1 ST_WNT_BETA_CATENIN_PATHWAY%MSIGDB_C2%ST_WNT_BETA_CATENIN_PATHWAY ST_WNT_BETA_CATENIN_PATHWAY Apc Axin1 Axin2 Mvp Gsk3b Cer1 Pin1 Dvl1 Gsk3a Ctnnb1 Sfrp1 Tshb Csnk1a1 Psen1 Akt3 Nkd1 Dkk2 Akt1 Ptpra Akt2 Cby1 Senp2 Dkk3 Dkk1 Ankrd6 Dkk4 Lrp1 Fstl1 Nkd2 Cxxc4 Dact1 Rpsa Wif1 PID_ENDOTHELIN_PATHWAY%MSIGDB_C2%PID_ENDOTHELIN_PATHWAY PID_ENDOTHELIN_PATHWAY Adcy1 Adcy4 Adcy3 Adcy8 Adcy5 Prkca Map2k1 Map2k2 Mapk14 Hras Mmp1a Adcy9 Fos Bcar1 Jak2 Gnaq Crk Akt1 Mapk8 Gna11 Gnai3 Rhoa Gnao1 Pla2g4a Gnaz Col3a1 Mapk1 Mapk3 Raf1 Rac1 Prkch Plcb3 Prkce Gnai2 Prkcq Adcy2 Src Prkcd Col1a2 Slc9a3 Slc9a1 Ednra Ednrb Edn3 Gnal Cysltr1 Trpc6 Cysltr2 Prkcg Jun Prkcb Ptk2b Gna12 Edn1 Gna14 Edn2 Adcy6 Gnai1 Plcb1 Gna15 Adcy7 Plcb2 PID_IL4_2PATHWAY%MSIGDB_C2%PID_IL4_2PATHWAY PID_IL4_2PATHWAY Selp Irf4 Shc1 Bcl2l1 Mapk14 Stat5b Cebpb Stat5a Mtor Egr2 Alox15 Jak2 Fes Dok2 Akt1 Mybl1 Inpp5d Irs1 Il2rg Jak1 Jak3 Parp14 Ets1 Il13ra2 Lta Il5 Il10 Stat6 Il4ra Ccl11 Cd40lg Il4 Spi1 Arg1 Itgb3 Myb Pik3ca Col1a2 Irs2 Retnlg Oprm1 Fcer2a Gtf3a Ptpn6 Aicda Pik3r1 Il13ra1 Pigr Socs3 Grb2 Tff3 Sp1 Hmga1 Bcl6 Socs5 Socs1 Col1a1 Cbl Thy1 Ccl17 NABA_BASEMENT_MEMBRANES%MSIGDB_C2%NABA_BASEMENT_MEMBRANES NABA_BASEMENT_MEMBRANES Col6a6 Col6a1 Lama4 Lamc3 Hspg2 Lama5 Ntng1 Lamc2 Col4a4 Lamc1 Col4a2 Col4a3 Col4a1 Lama3 Agrn Nid1 Col15a1 Nid2 Col18a1 Ush2a Lama1 Papln Col4a5 Ntn1 Tbc1d24 Colq Col4a6 Ntn4 Ntn5 Lama2 Col6a3 Col6a2 Lamb3 Lamb1 Npnt Lamb2 PID_SYNDECAN_4_PATHWAY%MSIGDB_C2%PID_SYNDECAN_4_PATHWAY PID_SYNDECAN_4_PATHWAY Tfpi Fzd7 Sdcbp Nudt16l1 Dnm2 Prkca Adam12 Prkcd Lama3 Fgf6 Cxcl12 Actn1 Itgb1 Tnc Cxcr4 Plg F2 Sdc4 Lama1 Fgf2 Fgfr1 Itga5 Gipc1 Ccl5 Rhoa Mdk Fn1 Thbs1 Mmp9 Tnfrsf13b Ptk2 Rac1 ST_STAT3_PATHWAY%MSIGDB_C2%ST_STAT3_PATHWAY ST_STAT3_PATHWAY Jak1 Il6 Il6ra Jak3 Src Cish Ptpru Reg1 Pias3 Jak2 Stat3 BIOCARTA_P53_PATHWAY%MSIGDB_C2%BIOCARTA_P53_PATHWAY BIOCARTA_P53_PATHWAY Timp3 Mdm2 Gadd45a Apaf1 Atm Bcl2 Ccne1 Bax Cdk4 Pcna E2f1 Cdkn1a Rb1 Trp53 Ccnd1 Cdk2 PID_P75_NTR_PATHWAY%MSIGDB_C2%PID_P75_NTR_PATHWAY PID_P75_NTR_PATHWAY Ikbkb Birc2 Shc1 Mageh1 Omg Mag Ngfrap1 Ndnl2 Zfp369 Bex1 Psen1 Sort1 Furin Trp53 Adam17 Bdnf Prkacb Lingo1 Rtn4r Rtn4 Ndn Mmp7 Plg Akt1 Ntf3 Xiap Diablo Mapk8 Ywhae Rhob Ncstn Rhoc Rhoa Traf6 Prdm4 Ikbkg Maged1 Irak1 Chuk Rac1 Apaf1 Birc3 Myd88 Ngfr Smpd2 Sqstm1 Pik3ca Bad Prkcz Mapk10 Ntf5 Mapk9 Aph1b Pik3r1 App Prkci Casp6 Casp3 E2f1 Arhgdia Casp9 Mmp3 Ripk2 Ntrk1 Bcl2l11 Ngf ST_INTERLEUKIN_4_PATHWAY%MSIGDB_C2%ST_INTERLEUKIN_4_PATHWAY ST_INTERLEUKIN_4_PATHWAY Sos1 Akt3 Il2rg Nr0b2 Jak1 Jak3 Akt1 Ppp1r13b Il13ra1 Iars Stat6 Inpp5d Il4ra Akt2 Grb2 Il4 Shc1 Src Cish Tyk2 Pik3ca Jak2 Sos2 BIOCARTA_ERK_PATHWAY%MSIGDB_C2%BIOCARTA_ERK_PATHWAY BIOCARTA_ERK_PATHWAY Sos1 Igf1r Mknk2 Pdgfra Ngfr Mknk1 Gnb1 Rps6ka1 Ptprr Map2k1 Shc1 Map2k2 Hras Src Itgb1 Myc Stat3 Grb2 Elk1 Egfr Gngt1 Ppp2ca Mapk1 Rps6ka5 Mapk3 Raf1 Ngf BIOCARTA_DEATH_PATHWAY%MSIGDB_C2%BIOCARTA_DEATH_PATHWAY BIOCARTA_DEATH_PATHWAY Apaf1 Dffa Dffb Birc2 Birc3 Casp7 Sptan1 Tnfsf12 Tnfrsf25 Lmna Gas2 Bcl2 Xiap Bid Casp6 Casp3 Casp9 Traf2 Cflar Tnfsf10 Map3k14 Fadd Nfkbia Tradd Ripk1 Casp8 Rela Nfkb1 Chuk Tnfrsf10b BIOCARTA_HER2_PATHWAY%MSIGDB_C2%BIOCARTA_HER2_PATHWAY BIOCARTA_HER2_PATHWAY Sos1 Il6st Erbb3 Il6 Erbb4 Pik3r1 Ep300 Carm1 Stat3 Grb2 Shc1 Map2k1 Pik3cg Il6ra Egfr Hras Grip1 Esr1 Pik3ca Mapk1 Mapk3 Raf1 WNT_SIGNALING%MSIGDB_C2%WNT_SIGNALING WNT_SIGNALING Apc Wnt9a Fzd7 Axin1 Lef1 Gsk3b Fzd1 Wnt1 Dvl1 Gsk3a Bcl9 Fshb Ctnnbip1 Tcf7l1 Fzd5 Tcf7 Wnt8a Ctbp1 Btrc Csnk1a1 Lrp5 Dvl2 Lrp6 Wnt7b Csnk1d Wnt7a Nkd1 Fzd8 Fzd2 Fzd6 Foxn1 Sox17 Fzd3 Fbxw11 Pygo1 Rhou Ctbp2 Porcn Daam1 Fbxw4 Dixdc1 Rpl13a Wnt5b Wnt5a Pitx2 Fbxw2 Wisp1 Wif1 Frzb Hprt Ccnd3 Wnt16 Slc9a3r1 Ep300 T Wnt3a Wnt2b Ctnnb1 Sfrp1 Fosl1 Sfrp4 Ccnd1 Myc Ccnd2 Wnt10a Tle1 Csnk1g1 Tle2 Kremen1 Wnt3 Fzd4 Jun Wnt11 Senp2 B2m Dkk1 Wnt2 Actb Nlk Ppp2ca Aes Ppp2r1a Wnt6 Cxxc4 Fgf4 Wnt4 PID_HIF1A_PATHWAY%MSIGDB_C2%PID_HIF1A_PATHWAY PID_HIF1A_PATHWAY Cops5 Vhl Hif1a Egln2 Cdkn2a Egln3 Rbx1 Gnb2l1 Hsp90aa1 Trp53 Naa10 Tceb1 Os9 Cul2 Hif3a Hif1an Arnt PID_NECTIN_PATHWAY%MSIGDB_C2%PID_NECTIN_PATHWAY PID_NECTIN_PATHWAY Cldn1 Pdgfrb Farp2 Pvrl2 Ctnnb1 Src Pip5k1c Itgb3 Ptprm Cdh1 F11r Pik3ca Pvrl1 Pvrl3 Tln1 Iqgap1 Crk Ctnna1 Pik3r1 Rapgef1 Rap1b Rap1a Mllt4 Pdgfb Ptk2 Itgav Rac1 Vav2 BIOCARTA_ERYTH_PATHWAY%MSIGDB_C2%BIOCARTA_ERYTH_PATHWAY BIOCARTA_ERYTH_PATHWAY Flt3 Csf2 Il6 Epo Igf1 Tgfb2 Csf3 Il1a Il9 Il11 Kitl Tgfb1 Tgfb3 BIOCARTA_BCR_PATHWAY%MSIGDB_C2%BIOCARTA_BCR_PATHWAY BIOCARTA_BCR_PATHWAY Sos1 Prkca Shc1 Cd79a Map2k1 Cd79b Mapk14 Nfatc3 Hras Nfatc1 Nfatc2 Plcg1 Fos Syk Btk Nfatc4 Mapk8 Vav1 Ppp3cc Ppp3ca Grb2 Ppp3cb Jun Elk1 Prkcb Map3k1 Lyn Mapk3 Blnk Raf1 Rac1 HALLMARK_PROTEIN_SECRETION%MSIGDB_C2%HALLMARK_PROTEIN_SECRETION HALLMARK_PROTEIN_SECRETION Cope Cd63 Tsg101 Rab14 Copb1 Galc Copb2 Lman1 Napg Adam10 Scamp3 Napa Sec31a Scamp1 Ocrl Ap3b1 Rab22a Rer1 Sgms1 Tspan8 Scrn1 Atp1a1 Clcn3 Stx7 Gm37240 Vamp4 M6pr Sec22b Vps45 Arfip1 Vamp7 Sspn Kif1b Igf2r Abca1 Vamp3 Gla Mapk1 Atp6v1b1 Ykt6 Ppt1 Ap2s1 Stam Pam Arfgef1 Atp7a Arfgef2 Ap3s1 Arfgap3 Krt18 Cog2 Lamp2 Cltc Vps4b Ica1 Dnm1l Cav2 Clta Gosr2 Ap2m1 Gbf1 Sh3gl2 Arf1 Rps6ka3 Snx2 Stx12 Zw10 Ap1g1 Rab5a Atp6v1h Ctsc Stx16 Egfr Bet1 Snap23 Tom1l1 Arcn1 Yipf6 Tmx1 Rab2a Rab9 Ergic3 Mon2 Sec24d Uso1 Anp32e Cln5 Golga4 Ap2b1 BIOCARTA_DNAFRAGMENT_PATHWAY%MSIGDB_C2%BIOCARTA_DNAFRAGMENT_PATHWAY BIOCARTA_DNAFRAGMENT_PATHWAY Endog Top2a Gzmb Top2b Dffa Dffb Hmgb2 Casp3 Casp7 BIOCARTA_IL6_PATHWAY%MSIGDB_C2%BIOCARTA_IL6_PATHWAY BIOCARTA_IL6_PATHWAY Sos1 Il6st Jak1 Il6 Jak3 Stat3 Ptpn11 Grb2 Shc1 Map2k1 Jun Elk1 Il6ra Cebpb Hras Tyk2 Srf Mapk3 Fos Jak2 Raf1 PID_RANBP2_PATHWAY%MSIGDB_C2%PID_RANBP2_PATHWAY PID_RANBP2_PATHWAY Xpo1 Mdm2 Ube2i Hdac1 Ranbp2 Hdac4 Ran Pias1 Pias2 PID_ATM_PATHWAY%MSIGDB_C2%PID_ATM_PATHWAY PID_ATM_PATHWAY Mre11a Cdc25c Cdc25a Atm Smc1a Rad50 Ube2n Blm Fancd2 Ctbp1 Rad17 Terf2 Smc3 Rad9a Dclre1c Trim28 Xrcc4 Mdm2 H2afx Uimc1 Fam175a Kat5 Trp53bp1 Chek2 Mdc1 Bid Rfwd2 Ywhab Nbn Rbbp8 Top3a Brca1 Abl1 BIOCARTA_TCAPOPTOSIS_PATHWAY%MSIGDB_C2%BIOCARTA_TCAPOPTOSIS_PATHWAY BIOCARTA_TCAPOPTOSIS_PATHWAY Fas Cd4 Fasl Cd247 Cd3d Ccr5 Cd3g Cd3e PID_EPHA2_FWD_PATHWAY%MSIGDB_C2%PID_EPHA2_FWD_PATHWAY PID_EPHA2_FWD_PATHWAY Tiam1 Pik3r1 Pak1 Arhgap35 Grb2 Rhoa Vav3 Shc1 Src Epha2 Ptk2 Pik3ca Acp1 Bcar1 Inppl1 Cbl Efna1 Rac1 Vav2 BIOCARTA_NFKB_PATHWAY%MSIGDB_C2%BIOCARTA_NFKB_PATHWAY BIOCARTA_NFKB_PATHWAY Tnfrsf1a Tnfrsf1b Ikbkb Il1a Myd88 Tnfaip3 Map3k14 Fadd Traf6 Map3k1 Tradd Nfkbia Ikbkg Ripk1 Rela Tab1 Nfkb1 Tlr4 Il1r1 Irak1 Chuk Map3k7 Tnf HALLMARK_TGF_BETA_SIGNALING%MSIGDB_C2%HALLMARK_TGF_BETA_SIGNALING HALLMARK_TGF_BETA_SIGNALING Apc Ppm1a Bmp2 Nog Id2 Smad1 Junb Furin Tgif1 Ncor2 Id1 Sptbn1 Eng Xiap Wwtr1 Smad3 Smurf2 Smurf1 Acvr1 Rhoa Ltbp2 Tgfb1 Smad6 Smad7 Ppp1ca Cdk9 Arid4b Bmpr2 Ube2d3 Bcar3 Ppp1r15a Lefty2 Id3 Bmpr1a Fnta Tgfbr1 Trim33 Rab31 Slc20a1 Ctnnb1 Cdh1 Skil Ifngr2 Klf10 Fkbp1a Hipk2 Hdac1 Cdkn1c Tjp1 Ski Thbs1 Pmepa1 Map3k7 Serpine1 PID_RET_PATHWAY%MSIGDB_C2%PID_RET_PATHWAY PID_RET_PATHWAY Sos1 Creb1 Prkca Shc1 Rasa1 Hras Src Gfra1 Pik3ca Prkaca Pxn Bcar1 Irs2 Gab1 Grb7 Crk Gdnf Grb10 Pik3r1 Dok1 Nck1 Mapk8 Frs2 Rap1a Ptpn11 Rhoa Grb2 Ret Dok6 Jun Shank3 Dok4 Ptk2 Dok5 Irs1 Mapk1 Mapk3 Rac1 BIOCARTA_AMI_PATHWAY%MSIGDB_C2%BIOCARTA_AMI_PATHWAY BIOCARTA_AMI_PATHWAY Plg Tfpi F2 F2r F10 Pros1 Serpinc1 Col4a5 F7 Col4a6 Col4a4 Col4a2 Col4a3 Col4a1 Proc Plat Fga Fgb Fgg HALLMARK_MTORC1_SIGNALING%MSIGDB_C2%HALLMARK_MTORC1_SIGNALING HALLMARK_MTORC1_SIGNALING Gpi1 Serp1 Gbe1 Got1 Acsl3 Sec11a Sla Nupr1 Rit1 Pfkl Tmem97 Hk2 Serpinh1 Edem1 Stc1 Hspa5 Ung Slc2a3 Pnp Ube2d3 Slc2a1 Slc9a3r1 Tbk1 Asns Slc7a11 Adipor2 Mcm4 Btg2 Eno1b Dhfr Rrm2 Psmc2 Mthfd2 Ifi30 Psmb5 Tcea1 Psmd12 Cdkn1a Psat1 Hspa9 Ssr1 Calr Hspa4 Cth Cops5 Psmg1 Vldlr Stip1 Canx Rpn1 Sqle Dapp1 Cyb5b Pdap1 Hmbs Psmc6 Psmc4 Itgb2 Tfrc Aurka Gmps Gclc Bub1 Acaca Ykt6 Tuba4a Me1 Tpi1 Ppia Psmd14 Pgm2 Skap2 Rpa1 Pgk1 Tes Qdpr Immt Nampt Hspd1 Rrp9 Etf1 Pik3r3 Xbp1 Ero1l Eprs Mcm2 Tubg1 Aldoa Bhlhe40 Nfyc Ddit3 Eno1 Slc37a4 Fdxr P4ha1 Psma4 Ldha Gsk3b Slc7a5 Ddit4 Plk1 Fgl2 Cxcr4 Wars Slc1a4 Acly Add3 Elovl6 Gtf2h1 Gla Ppp1r15a Hprt Cdc25a G6pdx Ddx39 Gsr Eif2s2 Slc6a6 Lta4h Sqstm1 Igfbp5 Bcat1 Ccnf Nmt1 Map2k3 Cfp Txnrd1 Uso1 Slc1a5 Glrx Ccng1 M6pr Ifrd1 Pdk1 Dhcr24 Nfkbib Shmt2 Atp2a2 Actr3 Actr2 Plod2 Nfil3 Cd9 Fads2 Dhcr7 Prdx1 Scd1 Hmgcr Sytl2 Gga2 Tomm40 Atp6v1d Mllt11 Ebp Pitpnb Fads1 Cyp51 Idi1 Cacybp Sdf2l1 Phgdh Arpc5l Uchl5 Fkbp2 Rdh11 Abcf2 Srd5a1 Egln3 Pno1 Psmd13 Ppa1 Psph Elovl5 Nup205 Polr3g Idh1 Nufip1 Coro1a Hsp90b1 Ctsc Lgmn Trib3 Insig1 Tm7sf2 Mthfd2l Stard4 Psme3 Eef1e1 Fam129a Ufm1 Rab1 Sc5d Ldlr Psma3 Sord BIOCARTA_STRESS_PATHWAY%MSIGDB_C2%BIOCARTA_STRESS_PATHWAY BIOCARTA_STRESS_PATHWAY Tnfrsf1a Ikbkb Tank Map2k3 Map2k4 Mapk8 Lta Traf2 Jun Mapk14 Map3k14 Cradd Map3k1 Tradd Nfkbia Ikbkg Ripk1 Rela Map2k6 Nfkb1 Casp2 Chuk Map4k2 Tnf PID_HDAC_CLASSII_PATHWAY%MSIGDB_C2%PID_HDAC_CLASSII_PATHWAY PID_HDAC_CLASSII_PATHWAY Hdac5 Camk4 Gnb1 Ube2i Gata1 Hdac4 Hdac9 Srf Ncor2 Ankra2 Nr3c1 Hdac6 Hdac7 Ywhae Hdac3 Tubb2a Bcor Xpo1 Rfxank Adrbk1 Gata2 Ywhab Ranbp2 Hdac11 Hsp90aa1 Hdac10 Bcl6 Tuba1b Esr1 Gng2 Ran Mef2c PID_ALK1_PATHWAY%MSIGDB_C2%PID_ALK1_PATHWAY PID_ALK1_PATHWAY Arrb2 Gdf2 Smad5 Smad4 Smad1 Id1 Fkbp1a Csnk2b Acvrl1 Eng Tlx2 Acvr1 Acvr2a Cav1 Inhba Smad7 Tgfb1 Ppp1ca Smad9 Tgfb3 Bmpr2 Mapk1 Mapk3 Acvr2b Tgfbr2 Tgfbr1 BIOCARTA_INSULIN_PATHWAY%MSIGDB_C2%BIOCARTA_INSULIN_PATHWAY BIOCARTA_INSULIN_PATHWAY Sos1 Pik3r1 Slc2a4 Mapk8 Ptpn11 Grb2 Shc1 Map2k1 Jun Pik3cg Rasa1 Elk1 Hras Srf Pik3ca Irs1 Mapk3 Ins2 Fos Insr Raf1 NABA_PROTEOGLYCANS%MSIGDB_C2%NABA_PROTEOGLYCANS NABA_PROTEOGLYCANS Ogn Srgn Aspn Rangap1 Podnl1 Kera Hspg2 Impg2 Ncan Impg1 Hapln2 Hapln1 Podn Hapln4 Hapln3 Epyc Esm1 Bgn Fmod Lum Dcn Prelp Bcan Chad Omd Spock2 Spock1 Nyx Spock3 Prg2 Prg3 Optc Vcan PID_AR_TF_PATHWAY%MSIGDB_C2%PID_AR_TF_PATHWAY PID_AR_TF_PATHWAY Gsk3b Ncoa2 Rchy1 Mapk14 Egr1 Pou2f1 Foxo1 Appbp2 Rel Hdac7 Mapk8 Nr2c1 Zmiz2 Gata2 Pde9a Ehmt2 Kat7 Rxra Senp1 Hsp90aa1 Trim24 Hoxb13 Smarce1 Rxrb Kat2b Crebbp Spdef Ep300 Sirt1 Src Gnb2l1 Map2k6 Nr3c1 Smarcc1 Cebpa Mdm2 Hdac1 Tmprss2 Dnaja1 Ar Kat5 Map2k4 Carm1 Ncoa1 Rxrg Nr0b1 Pkn1 Jun Nr2c2 Smarca2 BIOCARTA_UCALPAIN_PATHWAY%MSIGDB_C2%BIOCARTA_UCALPAIN_PATHWAY BIOCARTA_UCALPAIN_PATHWAY Tln1 Actn2 Ezr Actn3 Capns1 Acta1 Capn1 Capns2 Rhoa Src Sptan1 Itgb3 Ptk2 Pxn Actn1 Itgb1 Rac1 Itga1 PID_HEDGEHOG_GLI_PATHWAY%MSIGDB_C2%PID_HEDGEHOG_GLI_PATHWAY PID_HEDGEHOG_GLI_PATHWAY Gnai2 Sspo Gsk3b Crebbp Hdac2 Arrb2 Sufu Gli1 Gli2 Gli3 Shh Sin3a Ptch1 Gnb1 Map2k1 Spop Sap30 Prkcd Smo Csnk1a1 Lgals3 Foxa2 Pias1 Prkaca Csnk1e Csnk1d Kif3a Ift88 Rab23 Csnk1g2 Stk36 Hdac1 Csnk1g3 Akt1 Csnk1g1 Rbbp7 Gnai3 Fbxw11 Gnao1 Xpo1 Sin3b Gnaz Gm10094 Gnai1 Gng2 Mtss1 Ift172 Rbbp4 PID_REELIN_PATHWAY%MSIGDB_C2%PID_REELIN_PATHWAY PID_REELIN_PATHWAY Vldlr Gsk3b Itga3 Grin2b Pik3ca Itgb1 Map2k7 Dab1 Grin2a Crkl Reln Map3k11 Nck2 Cdk5 Akt1 Cdk5r1 Pik3r1 Map1b Rapgef1 Mapk8 Rap1a Fyn Lrpap1 Arhgef2 Pafah1b1 Mapk8ip1 Cbl PID_TCR_PATHWAY%MSIGDB_C2%PID_TCR_PATHWAY PID_TCR_PATHWAY Sos1 Lcp2 Ikbkb Stk39 Cd80 Prkca Card11 Shc1 Stim1 Bcl10 Pdpk1 Orai1 Sh3bp2 Hras Was Gab2 Flna Akt1 Ptprc Sla2 Rap1a Inpp5d Rassf5 Ptpn11 Trpv6 Pag1 Pten Map3k14 Traf6 Csk Rasgrp1 Ikbkg Cd86 Nras Malt1 Chuk Cd4 Prkce Prkcq H2-Eb1 Cd247 Cd3d Plcg1 Cd3g Cd3e Grap2 Map4k1 Fyb Ptpn6 Lat Nck1 Lck Vav1 Kras Zap70 Fyn Grb2 Map3k8 Itk Prkcb Rasgrp2 Dbnl Cbl BIOCARTA_CTLA4_PATHWAY%MSIGDB_C2%BIOCARTA_CTLA4_PATHWAY BIOCARTA_CTLA4_PATHWAY Ctla4 Icosl Pik3r1 Lck Cd80 H2-Eb1 Ptpn11 Grb2 Itk Il2 Cd247 Cd3d Cd86 Pik3ca Cd3g Icos Cd3e PID_TOLL_ENDOGENOUS_PATHWAY%MSIGDB_C2%PID_TOLL_ENDOGENOUS_PATHWAY PID_TOLL_ENDOGENOUS_PATHWAY Irak2 Ikbkb Ly96 Tlr6 Tlr3 Irak4 Tlr1 Tlr2 Myd88 Rhoa Cd14 Saa3 Ikbkg Sftpa1 Ticam1 S100a9 Tlr4 Hspd1 S100a8 Irak1 Tirap Vcan Chuk Bgn BIOCARTA_FMLP_PATHWAY%MSIGDB_C2%BIOCARTA_FMLP_PATHWAY BIOCARTA_FMLP_PATHWAY Camk1g Camk1 Pak1 Gnb1 Map2k1 Mapk14 Map2k2 Nfatc3 Hras Nfatc1 Nfatc2 Map2k6 Pik3c2g Map2k3 Nfatc4 Ppp3cc Ncf2 Ppp3ca Ppp3cb Fpr1 Elk1 Map3k1 Nfkbia Gngt1 Rela Nfkb1 Mapk1 Mapk3 Plcb1 Gna15 Raf1 Rac1 BIOCARTA_NEUROTRANSMITTERS_PATHWAY%MSIGDB_C2%BIOCARTA_NEUROTRANSMITTERS_PATHWAY BIOCARTA_NEUROTRANSMITTERS_PATHWAY Th Pnmt Hdc Gad1 Dbh Tph1 BIOCARTA_FAS_PATHWAY%MSIGDB_C2%BIOCARTA_FAS_PATHWAY BIOCARTA_FAS_PATHWAY Dffa Dffb Pak1 Casp7 Fas Fasl Daxx Sptan1 Rb1 Arhgdib Lmna Ptpn13 Lmnb2 Faf1 Prkdc Map2k4 Lmnb1 Pak2 Mapk8 Parp1 Casp6 Casp3 Jun Cflar Fadd Map3k1 Casp8 Ripk2 Map3k7 BIOCARTA_HSP27_PATHWAY%MSIGDB_C2%BIOCARTA_HSP27_PATHWAY BIOCARTA_HSP27_PATHWAY Acta1 Il1a Apaf1 Hspb1 Bcl2 Hspb2 Casp3 Casp9 Fas Fasl Daxx Mapkapk3 Mapkapk2 Tnf PID_CD8_TCR_PATHWAY%MSIGDB_C2%PID_CD8_TCR_PATHWAY PID_CD8_TCR_PATHWAY Sos1 Lcp2 Prf1 Ikbkb Cd80 Prkca Card11 Shc1 Stim1 Bcl10 Pdpk1 Orai1 Hras Akt1 Ptprc Rap1a Rassf5 Trpv6 Pag1 Map3k14 Traf6 Csk Rasgrp1 Ikbkg Cd86 Nras Malt1 Chuk Prkce Prkcq Cd247 Cd3d Plcg1 Cd3g Grap2 Cd3e Ptpn6 Lat Cd8b1 Lck Vav1 Kras Zap70 Fyn Grb2 Map3k8 B2m Prkcb Rasgrp2 H2-Q10 Cbl Cd8a ST_P38_MAPK_PATHWAY%MSIGDB_C2%ST_P38_MAPK_PATHWAY ST_P38_MAPK_PATHWAY Eef2k Tab2 Creb1 Dusp10 Mknk2 Mknk1 Mapk14 Srf Map2k6 Map3k5 Mapk12 Mapk11 Gadd45a Mapkapk5 Akt1 Dusp1 Mapk13 Map2k3 Map2k4 Hspb1 Eif4e Myef2 Elk1 Traf6 Map3k4 Nr2c2 Tab1 Nfkb1 Map3k10 Il1r1 Mapk1 Creb3 Map3k7 Mapkapk2 PID_ARF6_DOWNSTREAM_PATHWAY%MSIGDB_C2%PID_ARF6_DOWNSTREAM_PATHWAY PID_ARF6_DOWNSTREAM_PATHWAY Tiam1 Nme1 Arf1 Kalrn Rab11a Rhoa Arf6 Plaur Pld2 Mapk1 Mapk3 Rab11fip3 Pld1 Pip5k1a Rac1 PID_AJDISS_2PATHWAY%MSIGDB_C2%PID_AJDISS_2PATHWAY PID_AJDISS_2PATHWAY Igf1r Zbtb33 Crebbp Adam10 Cbll1 Rin2 Robo1 Cables1 Slit1 Dnm2 Dsp Met Ctnnb1 Ctnnd1 Src Hras Cdh1 Egf Arf6 Ptpn1 Gfra1 Bdnf Mep1b Cdh2 Mmp7 Iqgap1 Tiam1 Gdnf Nme1 Ctnna1 Ptpn6 Fyn Casp3 Ret Snx1 Rab5a Mmp3 Rab7 Egfr Hgs Gna13 Ntrk2 Gna12 Igf2 Jup Abl1 Rac1 PID_MET_PATHWAY%MSIGDB_C2%PID_MET_PATHWAY PID_MET_PATHWAY Apc Sos1 Pak4 Rin2 Hgf Sh3kbp1 Akt1s1 Eps15 Mlst8 Shc1 Map2k1 Map2k2 Pdpk1 Hras Egr1 Mtor Gab2 Rptor Ptpn1 Eif4ebp1 Pxn Bcar1 Deptor Muc20 Numb Crk Akt1 Ctnna1 Ptprj Rapgef1 Mapk8 Rap1b Eif4e Rap1a Inpp5d Ptpn11 Akt2 Rhoa Hgs Mapk1 Mapk3 Inppl1 Raf1 Rac1 Ets1 Pak1 Met Ctnnb1 Src Cdh1 Snai1 Arf6 Plcg1 Pik3ca F2rl2 Bad Prkcz Gab1 Wasl Ptpn2 Crkl Pard6a Sh3gl2 Nck2 Map2k4 Pik3r1 Nck1 Pak2 Prkci Grb2 Arhgef4 Jun Rab5a Map3k1 Ranbp9 Ptk2 Ranbp10 Cbl Kpnb1 PID_PRL_SIGNALING_EVENTS_PATHWAY%MSIGDB_C2%PID_PRL_SIGNALING_EVENTS_PATHWAY PID_PRL_SIGNALING_EVENTS_PATHWAY Ccna2 Rock1 Atf5 Ccne1 Ptp4a3 Rabggta Rabggtb Rhoc Rhoa Ptp4a2 Cdkn1a Agt Src Egr1 Tuba1b Mapk1 Mapk3 Cdk2 Itgb1 Bcar1 Itga1 Rac1 HALLMARK_OXIDATIVE_PHOSPHORYLATION%MSIGDB_C2%HALLMARK_OXIDATIVE_PHOSPHORYLATION HALLMARK_OXIDATIVE_PHOSPHORYLATION Vdac1 Ldha Ldhb Gpi1 Gm21987 Got2 Phb2 Polr2f Lrpprc Vdac3 Grpel1 Uqcrq Cox7b Etfb Idh3a Fxn Supv3l1 Cs Echs1 Acadm Ndufb4 Dld Casp7 Fh1 Aifm1 Idh3g Idh3b Eci1 Ndufa6 Iscu Bax Cyb5a Sucla2 Hccs Pdk4 Gpx4 Hspa9 Atp6v1h Ndufs2 Cox17 Slc25a3 Por Cpt1a Ndufc1 Ndufc2 Uqcrfs1 Mrps30 Mgst3 Cox7a2 Hadhb Pdhx Acat1 Acadvl Tomm22 Sdhd Ndufs7 Sdha Htra2 Atp1b1 Mtrr Sdhc Ndufs4 Uqcrc2 Mdh1 Timm9 Dlst Ndufs8 Mdh2 Atp6v1f Mtrf1 Cox4i1 Atp5a1 Atp5c1 Atp5d Mrpl34 Aldh6a1 Atp5g3 Ndufs1 Mrps22 Atp5b Timm8b Atp5k Opa1 Ogdh Tcirg1 Mrpl35 Cox7a2l Slc25a5 Ndufv2 Ndufa1 Ndufv1 Timm13 Etfa Pdha1 Slc25a4 Atp5f1 Atp6v1e1 Mpc1 Acadsb Mfn2 Nqo2 Cyb5r3 Mtx2 Pdhb Bdh2 Uqcrb Oxa1l Pmpca Atp6v1g1 Timm10 Mrpl11 Decr1 Acaa2 Pdp1 Suclg1 Hsd17b10 Fdx1 Nnt Ech1 Uqcrc1 Cyc1 Acaa1a Tomm70a Ndufb7 Uqcr10 Surf1 Sdhb Cox8a Vdac2 Atp6v1d Rhot2 Maob Immt Ndufab1 Ndufa5 Ndufa8 Atp5j Ndufa9 Dlat Phyh Hadha Atp6v1c1 Retsat Atp6v0b Etfdh Ndufa4 Ndufa7 Slc25a12 Oat Ndufa2 Ndufa3 Cox11 Slc25a11 Aco2 Idh2 Cox15 Bckdha Prdx3 Idh1 Atp6ap1 Glud1 Atp5j2 Cox10 Cox6a1 Timm50 Alas1 Afg3l2 Mrps11 Mrps15 Mrps12 Atp6v0e Ndufb6 Ndufb5 Ndufb8 Ndufb3 Cox6b1 Rhot1 Cox5a Slc25a20 Ndufb2 BIOCARTA_PTEN_PATHWAY%MSIGDB_C2%BIOCARTA_PTEN_PATHWAY BIOCARTA_PTEN_PATHWAY Sos1 Ilk Pdk2 Akt1 Pik3r1 Foxo3 Grb2 Shc1 Pten Pdpk1 Fasl Ptk2 Cdkn1b Pik3ca Mapk1 Mapk3 Itgb1 Bcar1 BIOCARTA_SPPA_PATHWAY%MSIGDB_C2%BIOCARTA_SPPA_PATHWAY BIOCARTA_SPPA_PATHWAY F2 F2r Prkca F2rl3 Gnb1 Map2k1 Pla2g4a Prkcb Hras Src Gngt1 Ptk2 Gnai1 Mapk1 Mapk3 Itgb1 Plcb1 Raf1 Syk Ptgs1 Itga1 Tbxas1 PID_LPA4_PATHWAY%MSIGDB_C2%PID_LPA4_PATHWAY PID_LPA4_PATHWAY Adcy1 Prkce Creb1 Adcy4 Gnal Adcy3 Adcy8 Adcy2 Adcy5 Lpar4 Adcy6 Rps6ka5 Prkaca Adcy9 Adcy7 ST_T_CELL_SIGNAL_TRANSDUCTION%MSIGDB_C2%ST_T_CELL_SIGNAL_TRANSDUCTION ST_T_CELL_SIGNAL_TRANSDUCTION Lcp2 Sos1 Pak6 Pak7 Pak3 Pak4 Pak1 Nfkbil1 Prdx1 Cd3d Fbxw7 Ephb2 Plcg1 Grap2 Tonsl Ctla4 Nfkb2 Lat Nck1 Pak2 Dtymk Ptprc Lck Vav1 Zap70 Grb2 Itk Nfkbib Csk Nfkbie Rasgrp4 Nfkbia Rasgrp1 Rasgrp2 Dag1 Rasgrp3 Nfkb1 Mapk1 Itpkb Cbl Sos2 Itpka Raf1 Nfat5 PID_FAK_PATHWAY%MSIGDB_C2%PID_FAK_PATHWAY PID_FAK_PATHWAY Sos1 Acta1 Itgb5 Arhgef28 Arhgap35 Ptpn21 Map2k1 Braf Pxn Itgb1 Bcar1 Crk Grb7 Rapgef1 Rap1b Mapk8 Itga5 Rap1a Bmx Rhoa Arhgap26 Vcl Mapk8ip3 Mapk1 Raf1 Rac1 Rras Pak1 Ets1 Elmo1 Rasa1 Yes1 Git2 Src Plcg1 Pik3ca Sh3gl1 Ccnd1 Klf8 Rock2 Actn1 Capn2 Tln1 Wasl Mapk9 Asap1 Nck2 Map2k4 Pik3r1 Nck1 Fyn Grb2 Jun Ptk2 Arhgef11 Dock1 Arhgef7 Itgav Mmp14 BIOCARTA_BARRESTIN_PATHWAY%MSIGDB_C2%BIOCARTA_BARRESTIN_PATHWAY BIOCARTA_BARRESTIN_PATHWAY Adcy1 Ap2m1 Arrb1 Gngt1 Ap2a1 Dnm1 Plcb1 Ppara Gnb1 PID_P38_GAMMA_DELTA_PATHWAY%MSIGDB_C2%PID_P38_GAMMA_DELTA_PATHWAY PID_P38_GAMMA_DELTA_PATHWAY Mapk12 Eef2k Stmn1 Mapk13 Map2k3 Map2k6 Snta1 Zak Ccnd1 Pkn1 PID_PI3K_PLC_TRK_PATHWAY%MSIGDB_C2%PID_PI3K_PLC_TRK_PATHWAY PID_PI3K_PLC_TRK_PATHWAY Sos1 Camk2a Gsk3b Creb1 Ywhaz Camk4 Shc1 Pdpk1 Stat5a Hras Trpv1 Src Agap2 Egr1 Prkcd Trpc3 Plcg1 Pik3ca Ccnd1 Bad Sfn Gab1 Akt1 Pik3r1 Ywhae Kras Foxo3 Grb2 Ywhab Nras Ntrk1 Ywhah Ywhag Ngf BIOCARTA_TCYTOTOXIC_PATHWAY%MSIGDB_C2%BIOCARTA_TCYTOTOXIC_PATHWAY BIOCARTA_TCYTOTOXIC_PATHWAY Icam1 Cd247 Itgal Cd3d Cd2 Ptprc Cd3g Cd3e Thy1 Itgb2 Cd8a PID_PTP1B_PATHWAY%MSIGDB_C2%PID_PTP1B_PATHWAY PID_PTP1B_PATHWAY Pdgfrb Prl Lepr Spry2 Lep Shc1 Stat5b Stat5a Egf Ptpn1 Fcgr3 Bcar1 Jak2 Cdh2 Crk Akt1 Capn1 Dok1 Stat3 Trpv6 Rhoa Csk Cav1 Irs1 Txn1 Csf1 Ybx1 Nox4 Yes1 Src Prlr Tyk2 Itgb3 Pik3ca Blk Ins2 Fer Insr Itga2b Lat Pik3r1 Hck Lck Csf1r Fyn Socs3 Grb2 Egfr Pdgfb Csn2 Fgr Lyn SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES%MSIGDB_C2%SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Ppp1r13b Cdkn2a Prex1 Cyth3 Phf11c Dapp1 Setdb2 Rps6ka1 Flot1 Pik3ca Flot2 Syk Akt3 Gab1 Nr0b2 Btk Plcg2 Akt1 Pdk1 Rps6ka3 Ptprc Vav1 Nr4a3 Sag Foxo3 Akt2 Itpr3 Cd19 Pten Rps6ka2 Pitx2 Lyn Itpr1 Pik3r5 Bcr Itpr2 BIOCARTA_PML_PATHWAY%MSIGDB_C2%BIOCARTA_PML_PATHWAY BIOCARTA_PML_PATHWAY Tnfrsf1a Tnfrsf1b Crebbp Pax3 Sirt1 Pram1 Fas Pml Fasl Daxx Hras Rb1 Trp53 Rara Tnf ST_INTERLEUKIN_13_PATHWAY%MSIGDB_C2%ST_INTERLEUKIN_13_PATHWAY ST_INTERLEUKIN_13_PATHWAY Jak1 Tyk2 Il13ra1 Il13ra2 Jak2 Il4ra Il13 BIOCARTA_RACCYCD_PATHWAY%MSIGDB_C2%BIOCARTA_RACCYCD_PATHWAY BIOCARTA_RACCYCD_PATHWAY Ikbkb Pak1 Tfdp1 Cdk6 Hras Rb1 Pik3ca Ccnd1 Cdk2 Akt1 Pik3r1 Ccne1 Cdk4 Rhoa E2f1 Cdkn1a Nfkbia Ikbkg Rela Nfkb1 Cdkn1b Mapk1 Mapk3 Chuk Raf1 Rac1 BIOCARTA_ETS_PATHWAY%MSIGDB_C2%BIOCARTA_ETS_PATHWAY BIOCARTA_ETS_PATHWAY E2f4 Hdac2 Hdac5 Etv3 Csf1 Ets1 Ddx20 Ets2 Csf1r Sin3a E2f1 Jun Sin3b Hras Ncor2 Rbl1 Fos Rbl2 PID_LKB1_PATHWAY%MSIGDB_C2%PID_LKB1_PATHWAY PID_LKB1_PATHWAY Prkab1 Gsk3b Creb1 Ywhaz Tsc2 Prkag1 Tsc1 Etv4 Akt1s1 Prkaa1 Prkaa2 Mlst8 Cab39 Smad4 Smarcd3 Ctsd Mtor Rptor Trp53 Cdc37 Psen2 Prkaca Sfn Myc Ezr Stk11ip Brsk1 Stk26 Sik2 Sik3 Stradb Ywhae Crtc2 Sik1 Brsk2 Strada Mark2 Stk11 Ywhab Mark4 Hsp90aa1 Esr1 Ywhah Ywhag BIOCARTA_HIVNEF_PATHWAY%MSIGDB_C2%BIOCARTA_HIVNEF_PATHWAY BIOCARTA_HIVNEF_PATHWAY Dffa Dffb Birc2 Fas Fasl Daxx Psen1 Arhgdib Lmna Casp2 Psen2 Lmnb2 Tnf Tnfrsf1a Bag4 Tnfrsf1b Xiap Lmnb1 Mapk8 Traf2 Cflar Map3k14 Fadd Tradd Nfkbia Ripk1 Casp8 Rela Nfkb1 Chuk Numa1 Actg1 Apaf1 Birc3 Casp7 Rasa1 Traf1 Cradd Sptan1 Prkcd Rb1 Map3k5 Map2k7 Mdm2 Gsn Prkdc Bcl2 Pak2 Parp1 Bid Casp6 Casp3 Casp9 Map3k1 Ptk2 Cdk11b PID_SYNDECAN_3_PATHWAY%MSIGDB_C2%PID_SYNDECAN_3_PATHWAY PID_SYNDECAN_3_PATHWAY Sdc3 Pomc Aph1b Ncstn Fyn Agrp Ncan Ptn Egfr Src Psen1 Mc4r Cask Cttn PID_MYC_PATHWAY%MSIGDB_C2%PID_MYC_PATHWAY PID_MYC_PATHWAY Axin1 Gsk3b Cdkn2a Pin1 Skp2 Ppp2r5a Pml Fbxw7 Ruvbl1 Kat2a Myc Zbtb17 Actl6a Kat5 Taf9 Pak2 Taf12 Ruvbl2 Ak6 Supt7l Hbp1 Ppp2ca Trrap Max Supt3 BIOCARTA_HIF_PATHWAY%MSIGDB_C2%BIOCARTA_HIF_PATHWAY BIOCARTA_HIF_PATHWAY Cops5 Nos3 Ldha Epo Vhl Hif1a Creb1 Ep300 Jun P4hb Asph Hsp90aa1 Edn1 Vegfa Arnt BIOCARTA_COMP_PATHWAY%MSIGDB_C2%BIOCARTA_COMP_PATHWAY BIOCARTA_COMP_PATHWAY Cfb C7 C1s2 C1qc C6 C3 C8a C9 Cfd C1rb C1qa C1qb C2 Mbl2 Masp2 Hc BIOCARTA_MET_PATHWAY%MSIGDB_C2%BIOCARTA_MET_PATHWAY BIOCARTA_MET_PATHWAY Sos1 Acta1 Hgf Pak1 Met Map2k1 Rasa1 Map2k2 Hras Src Pik3ca Pxn Itgb1 Fos Map4k1 Gab1 Crkl Crk Pik3r1 Rapgef1 Rap1b Mapk8 Rap1a Stat3 Ptpn11 Grb2 Jun Pik3cg Pten Elk1 Ptk2b Ptk2 Mapk1 Dock1 Mapk3 Raf1 Itga1 PID_CIRCADIAN_PATHWAY%MSIGDB_C2%PID_CIRCADIAN_PATHWAY PID_CIRCADIAN_PATHWAY Chek1 Nono Cry1 Per2 Cry2 Clock Nr1d1 Arntl Wdr5 Npas2 Bhlhe40 Timeless Per1 Csnk1e ST_FAS_SIGNALING_PATHWAY%MSIGDB_C2%ST_FAS_SIGNALING_PATHWAY ST_FAS_SIGNALING_PATHWAY Cad Il1a Dffa Nfkbil1 Cdk2ap1 Alg2 Dedd2 Fas Daxx Csnk1a1 Trp53 Faf1 Dedd Tonsl Nfkb2 Xiap Diablo Mapk8 Traf2 Pfn1 Nfkbib Nfkbie Pfn2 Fadd Ncs1 Nfkbia Ripk1 Casp8 Smpd1 Mapk8ip3 Nfkb1 Mapk8ip2 Mapk8ip1 Mapk1 Rock1 Tufm Met Bak1 Ephb2 Ptpn13 Faim2 Map3k5 Mapk10 Map2k7 Tpx2 Nr0b2 Ezr Btk Mapk9 Map2k4 Casp8ap2 Cd7 Hspb1 Bax Parp1 Casp3 Egfr Map3k1 Agfg1 Ralbp1 Nfat5 HALLMARK_E2F_TARGETS%MSIGDB_C2%HALLMARK_E2F_TARGETS HALLMARK_E2F_TARGETS Depdc1a Ssrp1 Smc3 Dctpp1 Tbrg4 Ung Ran Tipin Diap3 Cbx5 Cdkn2a Bub1b Timeless Tk1 Mcm4 Ranbp1 Rrm2 Shmt1 Prps1 Mthfd2 Ccne1 Cdkn1a Spc24 Brca1 Chek1 Srsf1 Espl1 Smc4 Mad2l1 Syncrip Tmpo Mki67 Birc5 Kif2c Cdc20 Mybl2 Nolc1 Cdk1 Tacc3 Aurkb H2afz H2afx Top2a Nme1 Tfrc Aurka Lmnb1 Dut Cdkn3 Cdkn1b Ccnb2 Ilf3 Bard1 Ctcf Rpa1 Rad50 Rad1 Usp1 Hmgb2 Ube2t Rfc1 Dek Prkdc Chek2 Ak2 Rsph10b Suv39h1 Orc2 Mcm3 Pms2 Cdk4 Mcm2 Tubg1 Mlh1 Hnrnpd Pds5b Cks1b Mcm5 Xrcc6 Mcm6 Wee1 Pa2g4 Mcm7 Stmn1 Pold3 Nap1l1 Kif4 Pold1 Hmgb3 Rad51c Pcna Pola2 Ccp110 Brca2 Pold2 Prim2 Plk1 Nop56 Plk4 Hus1 Rpa2 Rbbp7 Gspt1 Pole4 Dlgap5 Nbn Rfc3 Rfc2 Mxd3 Dscc1 Nup107 Psip1 Srsf2 Tubb5 Spc25 Cdc25a Dclre1b Rqcd1 Cdc25b Pop7 Cenpe Psmc3ip Kif18b Melk Ddx39 Prdx4 Smc1a Ing3 Cdca3 Exosc8 Smc6 Rad21 Ipo7 Racgap1 Gins4 Asf1a Atad2 Snrpb Mms22l Pttg1 Gins3 Rnaseh2a Gins1 Eed Wdr90 Luc7l3 Spag5 Orc6 Dck Asf1b Myc Ppp1r8 Lsm8 Hmmr Cdkn2c Stag1 Hn1 Eif2s1 Ezh2 Xpo1 Zw10 Lbr Hmga1 Tra2b Pole Nasp Kif22 Dnmt1 Anp32e Trp53 Ppm1d Cse1l Pnn Rad51ap1 Donson Lyar Pan2 Msh2 E2f8 Cenpm Ubr7 Phf5a Tcf19 Slbp Trip13 Paics Brms1l Ctps Mre11a Hells Nudt21 Lig1 Rpa3 Cit Nup205 Ncapd2 Cdca8 Nup153 BIOCARTA_GLEEVEC_PATHWAY%MSIGDB_C2%BIOCARTA_GLEEVEC_PATHWAY BIOCARTA_GLEEVEC_PATHWAY Sos1 Crkl Akt1 Map2k4 Pik3r1 Mapk8 Stat1 Grb2 Map2k1 Jun Pik3cg Stat5b Hras Stat5a Map3k1 Pik3ca Mapk3 Fos Bad Jak2 Myc Raf1 Bcr PID_NFAT_TFPATHWAY%MSIGDB_C2%PID_NFAT_TFPATHWAY PID_NFAT_TFPATHWAY Csf2 Irf4 Prkcq Cblb Il5 Egr4 Cd40lg Il4 Ifng Il2ra Il2 Dgka Fasl Junb Nfatc3 Gata3 Egr1 Fosl1 Egr2 Nfatc1 Pou2f1 Ptpn1 Nfatc2 Slc3a2 Egr3 Fos Foxp3 Batf3 Tnf Tle4 Itch Ctla4 Cdk4 Pparg Casp3 E2f1 Jun Ikzf1 Tbx21 Ptprk Ptgs2 Rnf128 Maf BIOCARTA_BARR_MAPK_PATHWAY%MSIGDB_C2%BIOCARTA_BARR_MAPK_PATHWAY BIOCARTA_BARR_MAPK_PATHWAY Map2k1 Map2k2 Adcy1 Arrb1 Gngt1 Mapk1 Dnm1 Mapk3 Plcb1 Raf1 Gnb1 BIOCARTA_TID_PATHWAY%MSIGDB_C2%BIOCARTA_TID_PATHWAY BIOCARTA_TID_PATHWAY Tnfrsf1a Dnaja3 Tnfrsf1b Ikbkb Ifng Wt1 Nfkbia Ush1c Rela Rb1 Trp53 Nfkb1 Ifngr1 Ifngr2 Lin7a Jak2 Hspa1a Tnf PID_TCR_RAS_PATHWAY%MSIGDB_C2%PID_TCR_RAS_PATHWAY PID_TCR_RAS_PATHWAY Prkca Kras Map2k1 Map3k8 Elk1 Hras Prkcb Ptpn7 Braf Nras Mapk1 Mapk3 Fos Raf1 BIOCARTA_SALMONELLA_PATHWAY%MSIGDB_C2%BIOCARTA_SALMONELLA_PATHWAY BIOCARTA_SALMONELLA_PATHWAY Wasf1 Wasl Arpc5 Acta1 Arpc1a Arpc2 Arpc3 Arpc4 Actr3 Actr2 Arpc1b Rac1 BIOCARTA_FCER1_PATHWAY%MSIGDB_C2%BIOCARTA_FCER1_PATHWAY BIOCARTA_FCER1_PATHWAY Sos1 Shc1 Map2k1 Nfatc3 Hras Nfatc1 Nfatc2 Plcg1 Pik3ca Fos Syk Map2k7 Btk Map2k4 Pik3r1 Pak2 Nfatc4 Mapk8 Fcer1a Vav1 Ppp3cc Ppp3ca Grb2 Ppp3cb Jun Pik3cg Elk1 Fcer1g Pla2g4a Prkcb Map3k1 Lyn Mapk1 Mapk3 Raf1 BIOCARTA_DC_PATHWAY%MSIGDB_C2%BIOCARTA_DC_PATHWAY BIOCARTA_DC_PATHWAY Csf2 Cd40 Ifnb1 Cd2 Cd7 Ifna16 Il10 Il5 Tlr2 Il4 Il13 Ifng Il12b Tlr9 Anpep Itgax Tlr7 Il12a Tlr4 Cd5 FANCONI ANEMIA PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FANCONI ANEMIA PATHWAY Fanconi anemia pathway Nbn Brip1 Chek1 Fbxw11 C230052I12Rik Rfc2 Rfc4 Rfc3 Rfc5 Palb2 Fancf Fancg Fanca Fancb Fancc Fancl Mre11a Top3a Xrcc3 Hes1 2310003H01Rik Rad50 Fan1 Hus1 Rad1 Blm Atm Rpa2 Rpa1 Trex1 Rad9a Fanci Btrc Ube2t Atrip Topbp1 Fancm H2afx Brca2 Fancd2 Apitd1 Rad17 Brca1 Usp1 Wdr48 IL8-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL8-MEDIATED SIGNALING EVENTS IL8-mediated signaling events FOXA2 AND FOXA3 TRANSCRIPTION FACTOR NETWORKS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXA2 AND FOXA3 TRANSCRIPTION FACTOR NETWORKS FOXA2 and FOXA3 transcription factor networks Creb1 Nf1 Gck Ins2 G6pc Acadm Foxa3 Foxf1 Abcc8 Pklr Tfrc Tat Aldob Sp1 Slc2a2 Hnf1a F2 Acadvl Apoa1 Alb Foxa2 Akt1 Dlk1 Pdx1 Bdh1 Cebpb Hnf4a Hadh Cpt1a Ttr Afp Foxa1 Pck1 Ucp2 Cebpa Igfbp1 Nr3c1 Kcnj11 Nkx2-1 Cpt1b Cpt1c Alas1 IL5-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL5-MEDIATED SIGNALING EVENTS IL5-mediated signaling events Ptpn11 Csf2rb2 Sdcbp Pik3ca Pik3r1 Il5 Lyn Il5ra Cish Stat5a Stat5b Jak2 Pim1 Grb2 SYNDECAN-4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-4-MEDIATED SIGNALING EVENTS Syndecan-4-mediated signaling events Tnfrsf13b Itga5 Mdk Nudt16l1 Ptk2 Fgf6 Fgf2 Ccl5 Adam12 Fgfr1 Mmp9 Tfpi Cxcl12 Rac1 Tnc F2 Prkcd Actn1 Dnm2 Rhoa Sdcbp Gipc1 Itgb1 Cxcr4 Thbs1 Prkca Plg Fn1 Lama1 Sdc4 Lama3 Fzd7 BCR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BCR SIGNALING PATHWAY BCR signaling pathway Akt1 Mapk1 Pten Mapk8 Dok1 Bcl2a1d Nfkb1 Fos Raf1 Pou2f2 Shc1 Chuk Ppp3cb Ppp3cc Ibtk Mapk3 Ppp3ca Jun Bcl10 Cd19 Pag1 Camk2g Btk Syk Ets1 Ikbkb Mapk14 Ptprc Blnk Map3k7 Malt1 Ikbkg Csk Fcgr2b Rac1 Sh3bp5 Pdpk1 Map2k1 Nfatc1 Cd79b Cd22 Vav2 Rela Cd72 Rasa1 Traf6 Map3k1 Dapp1 Cd79a Elk1 Hras Ptpn6 Plcg2 Card11 Nfkbia Sos1 Nfkbib Map4k1 Pik3ca Pik3r1 Lyn Grb2 AURORA B SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AURORA B SIGNALING Aurora B signaling Ppp1cc Rasa1 Pebp1 Kif20a Mylk Klhl9 Psma3 Ncaph Vim Cbx5 Des Ppp2r5d Tacc1 Cdca8 Aurkb Aurka Evi5 Npm1 Birc5 Kif2c Cul3 Klhl13 Nsun2 Bub1 Ndc80 Sept1 Ncapd2 Stmn1 Cenpa Rhoa Kif23 Racgap1 Incenp Smc4 Sgol1 Smc2 N-CADHERIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%N-CADHERIN SIGNALING EVENTS N-cadherin signaling events Camk2g Fgfr1 Rac1 Ctnnb1 Ctnnd1 Plcg1 Gja1 Pip5k1c Gsn Cdh2 Myl2 Ptpn1 Ptpn11 Kif5b Rock1 Mapk8 Jup Axin1 Gap43 Fer Cttn Cnr1 Mapre1 Dagla Gria2 Ctnna1 Daglb Dctn1 Lrp5 Rhoa Pik3ca Pik3r1 REGULATION OF TELOMERASE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF TELOMERASE Regulation of Telomerase Sp1 Akt1 Mapk1 Rad50 Hus1 Rad1 Nfkb1 Blm Fos Atm Mapk3 Rad9a Jun Nbn Znfx1 Ube3a Ifnar2 Mxd1 Ccnd1 Myc E2f1 Hnrnpc Pot1a Smg6 Tinf2 Dkc1 Sap30 Sin3b Max Sin3a Ywhae Xrcc5 Hsp90aa1 Parp2 Gm10094 Tnks Acd Mre11a Ifng Xrcc6 Esr1 Terf2ip Hdac1 Hdac2 Smad3 Terf1 Terf2 Rbbp4 Egfr Abl1 Irf1 Cdkn1b Tert Smg5 Nr2f2 Pinx1 Mtor Sp3 Egf Il2 Wrn Wt1 Tgfb1 Rbbp7 TRK RECEPTOR SIGNALING MEDIATED BY PI3K AND PLC-GAMMA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TRK RECEPTOR SIGNALING MEDIATED BY PI3K AND PLC-GAMMA Trk receptor signaling mediated by PI3K and PLC-gamma Camk2a Ntrk1 Creb1 Gab1 Agap2 Ywhag Ccnd1 Ywhah Gsk3b Nras Camk4 Sfn Ngf Src Egr1 Bad Trpv1 Ywhaz Ywhae Pdpk1 Kras Plcg1 Hras Akt1 Sos1 Shc1 Prkcd Pik3ca Pik3r1 Foxo3 Trpc3 Ywhab Stat5a Grb2 MTOR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%MTOR SIGNALING PATHWAY mTOR signaling pathway Eif4ebp1 Clip1 Yy1 Pml Deptor Srebf1 Braf Rictor Ccne1 Akt1 Rragd Mapk1 Eif4b Rragb Eif4e Rragc Eef2 Rraga Atg13 Raf1 Rb1cc1 Ppargc1a Sgk1 Mapkap1 Cdk2 Irs1 Poldip3 Mapk3 Eef2k Ulk2 Ulk1 Akt1s1 Eif4a1 Btrc Tsc2 Pdcd4 Mlst8 Tsc1 Prr5 Rps6ka1 Prkca Map2k2 Rrn3 Rptor Pld2 Ddit4 Pld1 Fbxw11 Ywhag Ywhah Ikbkb Nras Sfn Ywhaz Ywhae Pdpk1 Map2k1 Kras Hras Mtor Ywhab ROLE OF CALCINEURIN-DEPENDENT NFAT SIGNALING IN LYMPHOCYTES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ROLE OF CALCINEURIN-DEPENDENT NFAT SIGNALING IN LYMPHOCYTES Role of Calcineurin-dependent NFAT signaling in lymphocytes Ywhag Ywhah Gsk3b Mapk14 Camk4 Sfn Bad Mef2d Xpo1 Ywhaz Ywhae Nfatc1 Map3k1 Csnk1a1 Rcan2 Mapk9 Mapk8 Prkcq Kpnb1 Nr4a1 Map3k8 Ran Prkcb Prkce Prkcg Prkch Mapk3 Prkcd Crebbp Ep300 Casp3 Akap5 Bcl2 Prkcz Fkbp8 Nup214 Fkbp1a Prkca Nfatc3 Nfatc2 Ywhab Cabin1 Chp1 Rcan1 Pim1 Bcl2l1 Prkaca IL6-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL6-MEDIATED SIGNALING EVENTS IL6-mediated signaling events Gab1 Myc Mapk14 Lbp Rac1 Akt1 Ptpn11 Ptpre Socs3 Il6st Lmo4 Cebpb Fgg Vav1 Sos1 Mitf Fos Hsp90b1 Stat3 Hck Stat1 Foxo1 Prkcd Junb Tyk2 Irf1 Tnfsf11 Mapk11 Pias1 Il6 Pik3ca Jun Pik3r1 Pias3 Mcl1 Map2k4 Gab2 A2m Crp Map2k6 Jak2 Jak1 Il6ra Bcl2l1 Grb2 Timp1 SIGNALING EVENTS MEDIATED BY THE HEDGEHOG FAMILY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY THE HEDGEHOG FAMILY Signaling events mediated by the Hedgehog family Ihh Smo Lrp2 Hhat Tgfb2 Hhip Gli2 Gas1 Lrpap1 Ptch1 Adrbk1 Boc Pik3ca Cdon Pik3r1 Stil Pthlh Dhh Ptch2 Shh Arrb2 Akt1 SYNDECAN-3-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-3-MEDIATED SIGNALING EVENTS Syndecan-3-mediated signaling events Cttn Cask Aph1b Fyn Pomc Src Fgfr4 Fgfr3 Fgf15 Mc4r Ncstn Egfr Psen1 Ptn Fgf23 Agrp Ncan Sdc3 ATYPICAL NF-KAPPAB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATYPICAL NF-KAPPAB PATHWAY Atypical NF-kappaB pathway Lck Bcl3 Nfkbia Syk Nfkb1 Rel Ikbkb Mapk14 Src Btrc Pik3ca Pik3r1 Rela Arrb2 ARF1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF1 PATHWAY Arf1 pathway Cltb Clta Gga3 Gosr2 Arfgap1 Uso1 Copa Pip5k1a Arfip2 Rac1 Arf1 Kdelr1 Cyth2 Ap2a1 Cd4 Pld2 Ap2m1 Gbf1 Asap1 EGFR-DEPENDENT ENDOTHELIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EGFR-DEPENDENT ENDOTHELIN SIGNALING EVENTS EGFR-dependent Endothelin signaling events Egfr Sos1 Edn1 Ednra Mtor Shc1 Egf Hras Grb2 ATR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATR SIGNALING PATHWAY ATR signaling pathway Nbn Chek1 Fbxw11 Rfc2 Rfc4 Rfc3 Rfc5 Plk1 Cdc25c Ywhaz Timeless Ccna2 Cdc25a Rad51 Smarcal1 Tipin Mcm7 Cep164 Mdm2 Mcm2 Ppp2r2b Cdc6 Ppp2ca Clspn Ppp2r1a Hus1 Rad1 Cdk2 Rpa2 Rpa1 Trex1 Rad9a Btrc Atrip Topbp1 Brca2 Fancd2 Ywhab Rad17 FOXA TRANSCRIPTION FACTOR NETWORKS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXA TRANSCRIPTION FACTOR NETWORKS FOXA transcription factor networks Foxa3 Foxa1 Foxa2 S1P3 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P3 PATHWAY S1P3 pathway Akt3 Pdgfrb Src Rac1 Akt1 Mapk1 Mapk3 S1pr3 Gnai3 Gnai2 Pdgfb Rhoa Gnai1 Gnaz Flt1 Cxcr4 Vegfa Gnaq Gna11 Gna12 Gna13 Jak2 Gna14 Gna15 Gnao1 SHP2 SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SHP2 SIGNALING SHP2 signaling Lck Pdgfrb Mllt4 Tek Ifngr1 Nos3 Il2rg Bdnf Kdr Sdc2 Ntf5 Ntf3 Angpt1 Jak3 Il6st Ntrk3 Lmo4 Ntrk2 Igf1r Arhgap35 Il2rb Il2ra Raf1 Shc1 Frs2 Irs1 Frs3 Stat1 Rhoa Il6 Gab2 Map2k2 Jak1 Il6ra Pag1 Ntrk1 Gab1 Nras Ngf Map2k1 Kras Ifng Hras Ptpn11 Sos1 Egfr Gnai3 Pdgfb Pik3ca Gnai1 Pik3r1 Vegfa Egf Il2 Jak2 Grb2 Prkaca EPHA FORWARD SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHA FORWARD SIGNALING EPHA forward signaling Lck Fyn Src Vav2 Plcg1 Fgr Pik3cg Efna2 Efna1 Efna3 Cdk5 Crkl Rock1 Arhgef15 Cbl Pik3r6 Vav3 Crk Yes1 Epha1 Blk Epha3 Epha2 Epha6 Hck Ngef Efna5 Epha8 Epha5 Epha4 Epha7 Rhoa Lyn IL2 SIGNALING EVENTS MEDIATED BY PI3K%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL2 SIGNALING EVENTS MEDIATED BY PI3K IL2 signaling events mediated by PI3K Lck Myc E2f1 Rac1 Rela Hsp90aa1 Il2rg Akt1 Ptpn11 Jak3 Sos1 Nfkb1 Il2rb Il2ra Shc1 Sgms1 Tert Eif3a Bcl2 Prkcz Pik3ca Smpd1 Myb Pik3r1 Ugcg Foxo3 Mtor Gab2 Il2 Jak1 Bcl2l1 Grb2 P38 MAPK SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P38 MAPK SIGNALING PATHWAY p38 MAPK signaling pathway Map3k4 Map2k3 Gadd45g Taok3 Camk2b Taok1 Gadd45a Gadd45b Mapk14 Map3k3 Traf2 Map3k7 Rac1 Traf6 Map3k1 Atm Mapk11 Map3k5 Map3k6 Ccm2 Txn1 Map2k6 Map3k10 Tab1 Tab2 IL3-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL3-MEDIATED SIGNALING EVENTS IL3-mediated signaling events Ptpn11 Csf2rb2 Hdac1 Cebpb Ywhag Prkacb Id1 Shc1 Srp9 Ywhaz Pik3ca Il3ra Pik3r1 Cnksr1 Osm Gab2 Cish Stat5a Stat5b Jak2 Bcl2l1 Pim1 Prkaca Grb2 REELIN SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REELIN SIGNALING PATHWAY Reelin signaling pathway Gsk3b Pafah1b1 Arhgef2 Map1b Fyn Vldlr Grin2b Reln Map3k11 Itga3 Dab1 Grin2a Lrpap1 Cdk5r1 Rapgef1 Nck2 Rap1a Map2k7 Akt1 Cdk5 Crkl Mapk8 Cbl Pik3ca Itgb1 Pik3r1 VEGFR1 SPECIFIC SIGNALS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VEGFR1 SPECIFIC SIGNALS VEGFR1 specific signals Pdpk1 Rasa1 Hsp90aa1 Nos3 Plcg1 Akt1 Ptpn11 Mapk1 Cbl Prkcb Mapk3 Nrp1 Vegfb Cav1 Nck1 Hif1a Cd2ap Pik3ca Nrp2 Pik3r1 Flt1 Pgf Vegfa Prkca Shc2 Prkaca ARF6 TRAFFICKING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF6 TRAFFICKING EVENTS Arf6 trafficking events Rala Itga5 Exoc3 Scamp2 Avpr2 Acap1 Ins2 Itgav Arf6 Exoc6 Cdh1 Itga10 Itga7 Exoc5 Exoc4 Itga6 Itga3 Ctnnb1 Ctnnd1 Pip5k1c Adrb2 Vamp3 Asap2 Mapk8ip3 Slc2a4 Bin1 Ctnna1 Itga11 Itga8 Exoc1 Dnm2 Itga9 Spag9 Exoc2 Itgb1 Itga1 Itga2 Agtr1a Klc1 Itga4 Exoc7 Nme1 Tshr Pld2 Cpe Cltc Pld1 CALCIUM SIGNALING IN THE CD4+ TCR PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CALCIUM SIGNALING IN THE CD4+ TCR PATHWAY Calcium signaling in the CD4+ TCR pathway Rcan2 Fos Il2ra Fosl1 Il4 Junb Ptgs2 Batf3 Nfatc1 Cd40lg Akap5 Csf2 Jun Fasl Pou2f1 Fkbp1a Nfatc3 Nfatc2 Cabin1 Il2 Chp1 Rcan1 Ifng Prkaca INTEGRIN FAMILY CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTEGRIN FAMILY CELL SURFACE INTERACTIONS Integrin family cell surface interactions Itga5 Itgav Itga10 Itga7 Itgax Itga6 Itga3 Itgb2 Itgb3 Itgb4 Itgb5 Itgb6 Itgad Itgb8 Itgb7 Itga2b Itgam Itgal Itgae Itga11 Itga8 Itga9 Itgb1 Itga1 Itga2 Itga4 RAPID GLUCOCORTICOID SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RAPID GLUCOCORTICOID SIGNALING Rapid glucocorticoid signaling Mapk9 Mapk8 Mapk11 Mapk14 Gng2 Gnb1 Gnal Crh VEGFR3 SIGNALING IN LYMPHATIC ENDOTHELIUM%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VEGFR3 SIGNALING IN LYMPHATIC ENDOTHELIUM VEGFR3 signaling in lymphatic endothelium Itga5 Creb1 Mapk14 Akt1 Mapk1 Sos1 Crk Shc1 Mapk3 Col1a2 Mapk11 Col1a1 Figf Flt4 Pik3ca Pik3r1 Vegfc Itga1 Itgb1 Itga2 Map2k4 Rps6ka1 Itga4 Fn1 Grb2 GLYPICAN 3 NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN 3 NETWORK Glypican 3 network Mapk9 Mapk8 Ptch1 Gpc3 Furin Shh Bmp4 Fgf7 GMCSF-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GMCSF-MEDIATED SIGNALING EVENTS GMCSF-mediated signaling events Syk Ccl12 Ikbkb Csf2ra Irf8 Nras Ywhaz Map2k1 Csf2 Kras Hras Ptpn11 Mapk1 Csf2rb2 Sos1 Fos Raf1 Prkacb Shc1 Stat3 Stat1 Mapk3 Pik3ca Pik3r1 Osm Lyn Gab2 Cish Map2k2 Stat5a Stat5b Jak2 Pim1 Grb2 Prkaca PROTEOGLYCAN SYNDECAN-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PROTEOGLYCAN SYNDECAN-MEDIATED SIGNALING EVENTS Proteoglycan syndecan-mediated signaling events Sdc1 Sdc3 Sdc4 Sdc2 RAC1 SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RAC1 SIGNALING PATHWAY RAC1 signaling pathway Nckap1 Arhgdia Noxo1 Arpc3 Arpc2 Arpc1b Ncf2 Ncf1 Limk1 Noxa1 Bcar1 Pak2 Pip5k1b Pak1 Cyfip2 Map3k11 Arhgap5 Map2k7 Arpc5 Arpc4 Wasf2 Wasf1 Mapk8 Pip5k1a Stat3 Ctnna1 Iqgap3 Iqgap1 Nox1 Abi1 Actr3 Actr2 Jun Atf2 Plcb2 Cyba Map2k4 Brk1 Map2k6 Abi2 Cybb Baiap2 Map2k3 Mapk14 Cdh1 Rac1 Ctnnb1 Map3k1 Pip5k1c Mapk9 Crk Racgap1 Stat5a EPHA2 FORWARD SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHA2 FORWARD SIGNALING EPHA2 forward signaling Cbl Vav3 Arhgap35 Ptk2 Shc1 Bcar1 Epha2 Src Pak1 Rac1 Tiam1 Rhoa Acp1 Pik3ca Inppl1 Vav2 Pik3r1 Efna1 Grb2 ALPHA9 BETA1 INTEGRIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA9 BETA1 INTEGRIN SIGNALING EVENTS Alpha9 beta1 integrin signaling events Csf2ra Adam12 Bcar1 Src Rac1 Tnc Csf2 Paox Nos2 Vcam1 Kcnj15 Sat1 Spp1 F13a1 Itga9 Tgm2 Adam2 Figf Adam8 Pxn Vegfc Itgb1 Adam15 Vegfa Fn1 NETRIN-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NETRIN-MEDIATED SIGNALING EVENTS Netrin-mediated signaling events Dapk1 Camk2a Dock1 Trio Myo10 Agap2 Ptk2 Elmo1 Unc5b Unc5a Fyn Bcar1 Map1b Unc5c Src Pitpna Dcc Pak1 Rac1 Ntn1 Wasl Map2k1 Plcg1 Mapk1 Yes1 Mapk3 Nck1 Rhoa Pik3ca Pik3r1 Map2k2 CANONICAL NF-KAPPAB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CANONICAL NF-KAPPAB PATHWAY Canonical NF-kappaB pathway Erc1 Nfkbia Nfkb1 Ikbkb Atm Ran Chuk Malt1 Ikbkg Xpo1 Btrc Rela Bcl10 Birc2 Cyld Prkca Traf6 Tnf Ripk2 Tnfaip3 Nod2 Tnfrsf1a Ube2d3 VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL REPRESSION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL REPRESSION Validated targets of C-MYC transcriptional repression Creb1 Pdgfrb Hdac3 Fth1 Wnt5a Dnmt3a Smad4 Smad2 Ddit3 Gfi1 Id2 Clu Lgals1 Tmeff2 Zbtb17 Sp1 Cdkn1a Aldh9a1 Slc11a1 Dkk1 Cflar Nfya Nfyb Nfyc Tjp2 Zfp36l1 Tbp Ppp2r4 Ndrg1 Ndrg2 Erbb2 Csde1 Mxd4 Cdkn2b Dntt Sfrp1 Rbl1 Cebpa Tmem126a Sfxn3 Spi1 Hmgcs2 Gtf2h2 Tsc2 Itgb1 Brca1 Ccnd1 Myc Gadd45a Irf8 Ccl5 Max Itga6 Hdac1 Smad3 Itgb4 Ep300 Col1a2 Cdkn1b Bcl2 Foxo3 NONGENOTROPIC ANDROGEN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NONGENOTROPIC ANDROGEN SIGNALING Nongenotropic Androgen signaling Creb1 Ptk2 Src Rac1 Map2k1 Plcg1 Hras Akt1 Mapk1 Plcg2 Fos Raf1 Mapk3 Gnai3 Gnai2 Gnai1 Pik3ca Gnaz Pik3r1 Plcb2 Ar Gnrh1 Pelp1 Map2k2 Plcb3 Shbg Gng2 Plcb1 Gnb1 Gnao1 FAS (CD95) SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FAS (CD95) SIGNALING PATHWAY FAS (CD95) signaling pathway Btk Syk Ikbkb Mapk14 Src Ikbkg Casp8 Pdpk1 Bid Birc3 Fas Mapk10 Fasl Fadd Map2k7 Faim2 Birc2 Rfc1 Ripk1 Map3k1 Ezr Cflar Pik3cb Akt1 Mapk8 Mapk9 Chuk Casp3 Mapk11 Pik3ca Smpd1 Pik3r1 Map2k6 Cltc ALPHA-SYNUCLEIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA-SYNUCLEIN SIGNALING Alpha-synuclein signaling Lck Syk Fyn Src Bad Fgr Ppp2r5d Yes1 Ptk2b Blk Snca Stub1 Uchl1 Hck Grk5 Prkcd Ube2l3 Park7 Park2 Maob Tor1a Klk6 Th Slc6a3 Plcb2 Fkbp1a Lyn Pld2 Pld1 P63 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P63 TRANSCRIPTION FACTOR NETWORK p63 transcription factor network Trp63 DNA-PK PATHWAY IN NONHOMOLOGOUS END JOINING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DNA-PK PATHWAY IN NONHOMOLOGOUS END JOINING DNA-PK pathway in nonhomologous end joining Prkdc Aplf Dntt Poll Pnkp Aptx Prokr1 Polm Dclre1c Xrcc5 Lig4 Xrcc4 Xrcc6 SIGNALING EVENTS MEDIATED BY VEGFR1 AND VEGFR2%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY VEGFR1 AND VEGFR2 Signaling events mediated by VEGFR1 and VEGFR2 Braf Fyn Pak2 Nck2 Nos3 Kdr Akt1 Mapk1 Cdh5 Ptpn2 Rock1 Hgs Nedd4 Myof Sh2d2a Akap1 Vcl Raf1 Ctnna1 Mapk3 Prkcd Iqgap1 Dnm2 Mapk11 Rhoa Arf1 Hsp90ab1 Prkca Camkk2 Map2k2 Grb10 Shb Vtn Map2k6 Mapkapk2 Ptprj Fes Map2k3 Gab1 Fbxw11 Itgav Ptk2 Mapk14 Src Pdpk1 Map2k1 Ctnnb1 Hsp90aa1 Plcg1 Ptpn6 Ptpn11 Cbl Itgb3 Ptk2b Prkcb Cav1 Nck1 Pik3ca Pik3r1 Pxn Flt1 Vegfa Grb2 Prkaca SIGNALING EVENTS MEDIATED BY HDAC CLASS III%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HDAC CLASS III Signaling events mediated by HDAC Class III Sirt3 Hdac4 Sirt2 Fhl2 Bax Sirt1 Sirt7 Mef2d Tubb2a Trp53 Kat2b Cdkn1a Myod1 Hoxa10 Tuba1b Foxo4 Acss2 Hist1h1e Xrcc6 Acss1 Ppargc1a Foxo1 Crebbp Ep300 Foxo3 ALPHA4 BETA1 INTEGRIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA4 BETA1 INTEGRIN SIGNALING EVENTS Alpha4 beta1 integrin signaling events Dock1 Mdk Ptk2 Arf6 Bcar1 Src Rac1 Ywhaz Igsf8 Cd81 Git1 Jam2 Tln1 Crk Cd14 Ptk2b Prkacb Vcam1 Spp1 Abi1 Itgb1 Pxn Prkar1b Thbs1 Prkar1a Itga4 Adam28 Fn1 Ptpra Myh2 Amica1 Prkaca Thbs2 P75(NTR)-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P75(NTR)-MEDIATED SIGNALING p75(NTR)-mediated signaling Arhgdia Aph1b Trp53 Birc3 Mapk10 Bdnf Ntf5 Akt1 Ntf3 Mmp3 Xiap Mapk8 Rtn4r Apaf1 Rhob Diablo Rhoc Prkacb Shc1 Chuk App Irak1 Sqstm1 Mag Rhoa Prkci Maged1 Omg Mageh1 Casp6 Casp9 Plg Rtn4 Ndn Ngfr Mmp7 Myd88 Prdm4 Ntrk1 E2f1 Ikbkb Furin Ngf Ikbkg Bad Rac1 Ywhae Bcl2l11 Smpd2 Adam17 Ngfrap1 Ndnl2 Zfp369 Bex1 Sort1 Birc2 Traf6 Ripk2 Mapk9 Ncstn Psen1 Casp3 Pik3ca Prkcz Pik3r1 WNT SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%WNT SIGNALING NETWORK Wnt signaling network Cthrc1 Kremen2 Igfbp4 Wnt3a Wnt1 Wnt2 Wnt3 Ryk Lrp6 Fzd9 Fzd8 Atp6ap2 Wnt7a Wnt5a Wnt7b Fzd1 Rspo1 Dkk1 Kremen1 Lrp5 Fzd6 Fzd10 Fzd4 Fzd5 Fzd2 Wif1 Ror2 Fzd7 TRK RECEPTOR SIGNALING MEDIATED BY THE MAPK PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TRK RECEPTOR SIGNALING MEDIATED BY THE MAPK PATHWAY Trk receptor signaling mediated by the MAPK pathway Map2k3 Creb1 Braf Nras Mapk14 Egr1 Trpv1 Map2k1 Cdk5r1 Rap1a Kras Elk1 Hras Ntf3 Cdk5 Map2k5 Mapk1 Ehd4 Map3k2 Rap1b Rit2 Rit1 Fos Srf Raf1 Mef2c Mapk3 Mapk7 Rps6ka5 Prkcd Rps6ka1 Map2k6 Mapkapk2 EFFECTS OF BOTULINUM TOXIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EFFECTS OF BOTULINUM TOXIN Effects of Botulinum toxin Vamp2 Snap25 Syt1 Stxbp1 Chrna1 Unc13b Stx1a ARF6 DOWNSTREAM PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF6 DOWNSTREAM PATHWAY Arf6 downstream pathway Plaur Mapk1 Rab11a Kalrn Pip5k1a Rab11fip3 Arf6 Rac1 Mapk3 Tiam1 Rhoa Arf1 Nme1 Pld2 Pld1 SIGNALING EVENTS REGULATED BY RET TYROSINE KINASE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS REGULATED BY RET TYROSINE KINASE Signaling events regulated by Ret tyrosine kinase Creb1 Gab1 Ptk2 Bcar1 Src Rac1 Gfra1 Grb7 Irs2 Ret Rap1a Rasa1 Gdnf Dok5 Dok4 Hras Shank3 Dok6 Ptpn11 Mapk1 Mapk8 Dok1 Sos1 Crk Shc1 Frs2 Irs1 Mapk3 Nck1 Rhoa Pik3ca Jun Pxn Pik3r1 Prkca Grb10 Grb2 Prkaca NECTIN ADHESION PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NECTIN ADHESION PATHWAY Nectin adhesion pathway Ptk2 Itgav Pdgfrb Cdh1 Src Rac1 Mllt4 Rapgef1 Vav2 Ctnnb1 Rap1a Pip5k1c Rap1b Itgb3 Tln1 Crk Ptprm Ctnna1 Pvrl1 Pvrl2 Iqgap1 Cldn1 Pdgfb Pik3ca Farp2 Pvrl3 Pik3r1 F11r STABILIZATION AND EXPANSION OF THE E-CADHERIN ADHERENS JUNCTION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%STABILIZATION AND EXPANSION OF THE E-CADHERIN ADHERENS JUNCTION Stabilization and expansion of the E-cadherin adherens junction Nckap1 Exoc3 Stx4a Arf6 Zyx Hgf Cdh1 Met Lpp Myo6 Exoc4 Cyfip2 Kifc3 Camsap3 Mllt4 Mgat3 Plekha7 Vasp Diap1 Lima1 Ctnnb1 Aqp5 Aqp3 Ctnnd1 Pip5k1c Efna1 Myl2 Rock1 Git1 Igf1r Vcl Epha2 Ctnna1 Egfr Actn1 Pvrl2 Nck1 Abi1 Rhoa Egf IGF1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IGF1 PATHWAY IGF1 pathway Prkd1 Gnb2l1 Ptk2 Bcar1 Bad Ywhaz Ywhae Pdpk1 Irs2 Nck2 Hras Ptpn1 Akt1 Ptpn11 Crkl Igf1r Sos1 Crk Raf1 Shc1 Irs1 Prkcd Prkcz Pik3ca Pxn Pik3r1 Grb10 Grb2 SIGNALING EVENTS MEDIATED BY HEPATOCYTE GROWTH FACTOR RECEPTOR (C-MET)%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HEPATOCYTE GROWTH FACTOR RECEPTOR (C-MET) Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) Eif4ebp1 Deptor Hgf Bcar1 Met Pak2 Pak1 Rapgef1 Nck2 Inppl1 Rap1a Akt1 Mapk1 Ptpn2 Mapk8 Hgs Eif4e Raf1 Shc1 Ctnna1 Mapk3 Akt1s1 Rhoa Prkci Jun Mlst8 Map2k4 Gab2 Map2k2 Rptor Ptprj Gab1 Ets1 Ptk2 Arf6 Cdh1 Src Egr1 Bad Rac1 Wasl Pdpk1 Map2k1 Ctnnb1 Plcg1 Map3k1 Hras Ptpn1 Ptpn11 Akt2 Ranbp9 Crkl Apc Rab5a Rap1b Cbl Arhgef4 Kpnb1 Eps15 Sos1 Muc20 Crk Ranbp10 Snai1 Sh3gl2 Pak4 F2rl2 Sh3kbp1 Numb Pard6a Rin2 Nck1 Prkcz Pik3ca Pxn Pik3r1 Mtor Grb2 ATM PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATM PATHWAY ATM pathway Nbn Kat5 Ube2n Chek2 Trp53bp1 Smc1a Fam175a Ctbp1 Rbbp8 Uimc1 Smc3 Trim28 Mdc1 Rfwd2 Cdc25c Dclre1c Bid Cdc25a Xrcc4 Mdm2 Mre11a Top3a Rad50 Terf2 Blm Atm Rad9a Abl1 H2afx Fancd2 Ywhab Rad17 Brca1 TCR SIGNALING IN NAIVE CD8+ T CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TCR SIGNALING IN NAIVE CD8+ T CELLS TCR signaling in naive CD8+ T cells Lck Fyn Rap1a Akt1 Vav1 Shc1 Chuk Bcl10 Prkca Pag1 Trpv6 Cd86 Cd80 Cd8b1 Prf1 Ikbkb Rassf5 Nras Ptprc B2m Lat Zap70 Map3k14 Malt1 Lcp2 Ikbkg Cd247 Csk Rasgrp1 Rasgrp2 Pdpk1 Orai1 Grap2 Cd8a H2-Q10 Stim1 Cd3d Cd3e Cd3g Kras Plcg1 Traf6 Hras Ptpn6 Cbl Prkcq Card11 Sos1 Map3k8 Prkcb Prkce Grb2 LPA RECEPTOR MEDIATED EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LPA RECEPTOR MEDIATED EVENTS LPA receptor mediated events Prkd1 Bcar1 Tiam1 Lpar1 Trip6 Adra1b Adcy1 Adcy2 Lpar2 Slc9a3r2 Pik3cb Lpar3 Akt1 Lpar4 Adcy9 Adcy8 Adcy7 Mmp2 Adcy6 Nfkb1 Adcy5 Fos Adcy4 Adcy3 Hbegf Arhgef1 Prkcd Rhoa Jun Plcb3 Pld2 Gab1 Ptk2 Gsk3b Src Mmp9 Rac1 Rela Plcg1 Hras Nfkbia Crk Ptk2b Prkce Egfr Casp3 Gnai3 Gnai2 Gnai1 Pik3r1 Gnaz Pxn Lyn Gnaq Gna11 Gna12 Gng2 Gna13 Gna14 Gnb1 Gna15 Gnao1 RXR AND RAR HETERODIMERIZATION WITH OTHER NUCLEAR RECEPTOR%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RXR AND RAR HETERODIMERIZATION WITH OTHER NUCLEAR RECEPTOR RXR and RAR heterodimerization with other nuclear receptor Srebf1 Med1 Tnf Nr4a1 Nr1h3 Rarg Ncoa1 Fam120b Vdr Nr1h4 Rxrg Nr1h2 Bcl2 Thrb Rxrb Rxra Abca1 Pparg Thra Ncor2 Rara Rarb Tgfb1 Ppara Ppard NOTCH SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NOTCH SIGNALING PATHWAY Notch signaling pathway Yy1 Ctbp1 Aph1b Cdkn1a Dlk1 Il4 Btrc Maml2 Maml1 Cul1 Notch4 Notch3 Ccnd1 Notch2 Rbbp8 Rab11a Myc Dtx1 Notch1 Furin Adam12 Mark2 Adam10 Kdm1a Eno1 Cntn1 Itch Mycbp Rbpj Cntn6 Ptcra Mib1 Spen Jag1 Lnx1 Mfap5 Jag2 Mfap2 Ncor1 Fbxw7 Dnm1 Hdac1 Skp2 Cbl Eps15 Dll3 Dll1 Neurl1a Gata3 Eno1b Dll4 Numb Skp1a Dner Ncstn Ep300 Ncor2 DIRECT P53 EFFECTORS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DIRECT P53 EFFECTORS Direct p53 effectors Bid Fas Cdkn1a Dkk1 Nfya Nfyb Nfyc Mmp2 Apaf1 Ndrg1 Mcl1 Casp6 E2f1 Mdm2 Dusp1 Irf5 Dusp5 Hdac2 Htt Ak6 Carm1 Tigar Pou4f1 Cx3cl1 Pou4f2 Pcna Cse1l Bak1 Tgfa Prdm1 Edn2 Crebbp Egfr Spp1 Ep300 Vdr Cav1 Bcl2 Prmt1 Plk3 Smarca4 Cd82 Tfdp1 Serpine1 Arid3a Trp63 Jmy Col18a1 Bcl2l1 Trrap Bcl2l2 Drosha Rps27l Pml Bcl6 Tap1 Bax Atf3 Steap3 Tyrp1 Taf9 Igfbp3 Lif Hgf Met Ddb2 Ctsd Nlrc4 Pidd1 Trp53bp2 Dgcr8 Rb1 Fdxr Pcbp4 Trp53 Aifm2 Bdkrb2 Gdf15 Zfp385a Sp1 Sesn1 Ddx5 Snai2 Ccnk Prkab1 Casp1 Vcan Ppm1j Pms2 Rnf144b Pten Rchy1 Bcl2a1d Hspa1a Btg2 E2f2 Trp53inp1 Afp Trp73 Foxa1 Rsph10b E2f3 Ccng1 Ppp1r13b Kat2a Tnfrsf10b Perp Gpx1 Msh2 Sh2d1a Tsc2 Bnip3l Rgcc Mlh1 Jun Pycard Serpinb5 Rrm2b Cebpz Hic1 Bcl2l14 Scn3b Ddit4 Triap1 Map4k4 Gadd45a Sfn Rfwd2 Apc Epha2 BETA5 BETA6 BETA7 AND BETA8 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA5 BETA6 BETA7 AND BETA8 INTEGRIN CELL SURFACE INTERACTIONS Beta5 beta6 beta7 and beta8 integrin cell surface interactions Plaur Sdc1 Itgav Itgb5 Itgb6 Itgb8 Vcam1 Itgb7 Madcam1 Edil3 Itga4 Fn1 Fbn1 Vtn Tgfbr1 Cyr61 Plau POSTTRANSLATIONAL REGULATION OF ADHERENS JUNCTION STABILITY AND DISSASSEMBLY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%POSTTRANSLATIONAL REGULATION OF ADHERENS JUNCTION STABILITY AND DISSASSEMBLY Posttranslational regulation of adherens junction stability and dissassembly Zbtb33 Igf2 Cbll1 Cables1 Rab7 Slit1 Dsp Arf6 Fyn Cdh1 Met Src Mep1b Robo1 Adam10 Rac1 Snx1 Gfra1 Tiam1 Ret Ctnnb1 Ctnnd1 Gdnf Bdnf Cdh2 Hras Ptpn1 Ptpn6 Mmp3 Hgs Jup Rab5a Ntrk2 Igf1r Ctnna1 Rin2 Egfr Crebbp Abl1 Iqgap1 Casp3 Dnm2 Egf Gna12 Gna13 Nme1 Mmp7 VALIDATED NUCLEAR ESTROGEN RECEPTOR ALPHA NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED NUCLEAR ESTROGEN RECEPTOR ALPHA NETWORK Validated nuclear estrogen receptor alpha network Hdac4 Med1 Ctsd Smad4 Lmo4 Cebpb Chuk Jun Brca1 Xbp1 Ndufv3 Prdm15 Atp5j Hsf2 Ccnd1 Dscam Myc Ebag9 Ube2m Pdia2 Anp32a Nrip1 Ddx17 Nr0b2 Ncoa7 Nedd8 Nr0b1 Esr2 Ncor1 Esr1 Hdac1 Greb1 Trim59 Calcoco1 Pou4f1 Lcor Pou4f2 Pcna Ncoa1 Phb2 Mpg Ep300 Uba3 Ncoa3 Ncoa2 C3 Prl Pgr Mta1 Safb Cd82 Apbb1 Stat5a Abca3 Ncor2 Ddx54 Ap1b1 Axin2 Col18a1 Sra1 ERBB1 DOWNSTREAM SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB1 DOWNSTREAM SIGNALING ErbB1 downstream signaling Pik3cb Smad1 Diap3 Usp6nl Arf4 Ppp2r2a Rps6ka3 Ralgds Ksr1 Eps8 Slc9a1 Rps6ka4 Dusp6 Stat3 Capn2 Stat1 Rin1 Prkcd Map2k4 Prkca Zfp36 Ppp5c Mylpf Rala Wasl Ywhae Pdpk1 Map2k1 Vav2 Map3k1 Ppp2ca Elk1 Hras Ppp2r1a Dusp1 Map2k5 Mapk9 Map3k2 Sos1 Srf Mef2c Mapk7 Rps6ka5 Egfr Prkcz Mtor Egf Bcl2l1 Nckap1 Creb1 Arpc3 Arpc2 Arpc1b Braf Rictor Cyfip2 Arpc5 Pebp1 Arpc4 Wasf2 Akt1 Mapk1 Mapk8 Sh2d2a Fos Raf1 Mapkap1 Mapk3 Iqgap1 Abi1 Actr3 Actr2 Mlst8 Jun Atf2 Map2k2 Brk1 Pld2 Pld1 Baiap2 Gab1 Ywhag Ywhah Nras Sfn Src Egr1 Bad Rac1 Ywhaz Kras Rab5a F2rl2 Pik3ca Pik3r1 Ywhab Grb2 VISUAL SIGNAL TRANSDUCTION: RODS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VISUAL SIGNAL TRANSDUCTION: RODS Visual signal transduction: Rods Rho Grk1 Guca1a Guca1b Gnb5 Rdh12 Pde6g Slc24a1 Rgs9 Gngt1 Rgs9bp Sag Rdh5 Gucy2e Lrat Pde6a Gnat1 Gucy2f Pde6b Gnb1 Rpe65 Cnga1 INTERNALIZATION OF ERBB1%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTERNALIZATION OF ERBB1 Internalization of ErbB1 Stambp Spry2 Epn1 Ube2d1 Itsn1 Synj1 Ptk2 Chmp3 Tsg101 Nras Cblb Src Kras Usp8 Zfyve28 Amph Pik3cb Hras Arhgef7 Dnm1 Lrig1 Ube2d3 Hgs Rab5a Cbl Sos1 Eps15 Raf1 Shc1 Sh3gl2 Sh3kbp1 Egfr Pik3ca Pik3r1 Egf Grb2 CDC42 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CDC42 SIGNALING EVENTS CDC42 signaling events Arhgdia Arpc3 Arpc2 Arpc1b Braf Limk1 Bcar1 Pak2 Pak1 Map3k11 Tiam1 Map2k7 Arpc5 Arpc4 Arhgef7 Mapk1 Diap3 Mapk8 Raf1 Eps8 Ctnna1 Mapk3 Iqgap3 Iqgap1 Actr3 Actr2 Jun Atf2 Map2k4 Exoc7 Map2k6 Baiap2 Pld1 Map2k3 Gsk3b Mapk14 Cdh1 Src Rac1 Wasl Sept2 Pax6 Vav2 Hes5 Tnk2 Ctnnb1 Limk2 Cdc42bpa Arhgef6 Rasgrf1 Map3k1 Dlg1 Myl2 Hras Apc Mapk9 Cbl Yes1 Prkce Pak4 F2rl2 Pard6a Pik3ca Prkcz Pik3r1 Mtor REGULATION OF CYTOPLASMIC AND NUCLEAR SMAD2 3 SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF CYTOPLASMIC AND NUCLEAR SMAD2 3 SIGNALING Regulation of cytoplasmic and nuclear SMAD2 3 signaling Mapk1 Ctdspl Ube2i Ppm1a Ctdsp1 Kpnb1 Smad3 Pias4 Nup153 Mapk3 Smad4 Smad2 Nup214 Map3k1 OSTEOPONTIN-MEDIATED EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%OSTEOPONTIN-MEDIATED EVENTS Osteopontin-mediated events Syk Itgav Bcar1 Mmp9 Map3k14 Rac1 Rela Map3k1 Gsn Plau Mapk1 Mapk8 Mmp2 Nfkbia Itgb3 Nfkb1 Vav3 Fos Pip5k1a Ptk2b Chuk Mapk3 Spp1 Rock2 Rhoa Pik3ca Jun Pik3r1 Cd44 Ilk NOTCH-MEDIATED HES HEY NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NOTCH-MEDIATED HES HEY NETWORK Notch-mediated HES HEY network Maml2 Maml1 Yy1 Ctbp1 Rbbp8 E2f1 Notch1 Gaa Ptf1a Hey2 Hey1 Twist1 Kdm1a Gata6 Rb1 Camk2d Gata1 Rbpj Gata4 Tle1 Arnt Parp1 Tcf3 Spen Myod1 Runx2 Kdr Hes6 Ncor1 Neurog3 Ghr Ascl1 Hes1 Hdac1 Stat3 Ncoa1 Crebbp Ep300 Cdkn1b Hif1a Myb Ar Ncor2 Cd4 Jak2 Rcan1 INTEGRINS IN ANGIOGENESIS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTEGRINS IN ANGIOGENESIS Integrins in angiogenesis Bcar1 Col2a1 Casp8 Csf1r Pi4ka Col7a1 Col6a3 Col6a2 Kdr Col6a1 Angptl3 Pik3c2a Akt1 Col3a1 Mapk1 Rock1 Igf1r Vcl Irs1 Mapk3 Rhoa F11r Ilk Fn1 Vtn Sdc1 Itgav Ptk2 Fgf2 Src Rac1 Edil3 Hsp90aa1 Ptpn11 Cbl Itgb3 Vav3 Tln1 Ptk2b Mfge8 Spp1 Col11a2 Col1a2 Col11a1 Col1a1 Cdkn1b Col4a4 Pik3ca Pik3r1 Pxn Adgra2 Csf1 Col4a6 Vegfa Col5a1 Col4a5 Pi4kb Col4a3 Tgfbr2 Col4a1 Col5a2 ENDOTHELINS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ENDOTHELINS Endothelins Bcar1 Adcy1 Adcy2 Akt1 Col3a1 Mapk1 Adcy9 Adcy8 Mapk8 Adcy7 Adcy6 Adcy5 Fos Adcy4 Adcy3 Raf1 Slc9a1 Mapk3 Prkcd Rhoa Jun Edn1 Plcb2 Ednra Prkca Map2k2 Trpc6 Plcb3 Pla2g4a Plcb1 Cysltr2 Cysltr1 Ednrb Slc9a3 Mmp1a Edn3 Mapk14 Src Rac1 Map2k1 Hras Prkcq Crk Prkcb Ptk2b Prkce Prkcg Prkch Edn2 Col1a2 Gnai3 Gnai2 Gnai1 Gnaz Gnaq Gna11 Gna12 Gna14 Jak2 Gnal Gna15 Gnao1 CXCR4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CXCR4-MEDIATED SIGNALING EVENTS CXCR4-mediated signaling events Lck Gnb2l1 Rictor Limk1 Bcar1 Fyn Pak1 Pik3cb Akt1 Hgs Rhob Vav1 Ralb Rhoc H2-Eb1 Ubqln1 Grk6 Vps4a Mapkap1 Stat2 Rgs1 Stat3 Vps4b Hck Ssh1 Stat1 Foxo1 Arr3 Rhoa Mlst8 Cxcr4 Plcb2 Plcb3 Cd4 Plcb1 Pag1 Ptk2 Ptprc Mmp9 Src Cxcl12 Bad Cd247 Csk Rac1 Pdpk1 Itch Adrbk1 Cd3d Cd3e Cd3g Fgr Pik3cg Arrb2 Ptpn6 Dnm1 Ptpn11 Rap1b Pik3r6 Crk Yes1 Ptk2b Blk Gnai3 Gnai2 Gnai1 Prkcz Pik3ca Pik3r1 Pxn Gnaz Lyn Mtor Stat5a Gng2 Gna13 Stat5b Jak2 Gnb1 Gnao1 PDGFR-ALPHA SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PDGFR-ALPHA SIGNALING PATHWAY PDGFR-alpha signaling pathway Cav3 Crkl Pdgfra Shf Itgav Sos1 Fos Crk Srf Shc1 Cav1 Rapgef1 Pik3ca Jun Pik3r1 Plcg1 Shb Jak1 Elk1 Grb2 SIGNALING BY AURORA KINASES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING BY AURORA KINASES Signaling by Aurora kinases Aurkb Aurka REGULATION OF P38-ALPHA AND P38-BETA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF P38-ALPHA AND P38-BETA Regulation of p38-alpha and p38-beta Rala Map2k3 Lck Mapk14 Map3k3 Fyn Src Pak2 Pak1 Rac1 Map3k12 Dusp16 Dusp10 Traf6 Fgr Ripk1 Dusp8 Pak3 Dusp1 Ralb Yes1 Blk Hck Mapk11 Map2k4 Lyn Ccm2 Map2k6 Tab1 PAR4-MEDIATED THROMBIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PAR4-MEDIATED THROMBIN SIGNALING EVENTS PAR4-mediated thrombin signaling events Rock1 F2rl2 Rock2 F2rl3 Rhoa Plcb2 Gnaq Gna11 F2 Gng2 Gna13 Gnb1 Gna14 Gna15 Myl2 BETA2 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA2 INTEGRIN CELL SURFACE INTERACTIONS Beta2 integrin cell surface interactions Plaur Itgax Cd40lg Cyr61 Plau Itgb2 Fgg Itgad Vcam1 Itgam Itgal Jam3 F10 Gp1ba Spon2 C3 Fgb Kng2 F11r Tgfbi Icam2 Icam4 Fga Proc Fcgr3 Thy1 Icam1 Plat REGULATION OF NUCLEAR BETA CATENIN SIGNALING AND TARGET GENE TRANSCRIPTION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF NUCLEAR BETA CATENIN SIGNALING AND TARGET GENE TRANSCRIPTION Regulation of nuclear beta catenin signaling and target gene transcription mt-Co2 Ctbp1 Cacna1g Ruvbl2 Tbl1xr1 Cdx4 Chd8 Id2 Fgf4 Sall4 Tnik Cdx1 Pitx2 Kcnip4 Zcchc12 Tle4 Snai2 Tle2 Dkk1 Cdkn2a T Med12 Vcan Ccnd2 Dvl3 Bcl9 Adcy7 Tcf7l1 Mmp2 Lef1 Tcf7l2 Ctnnbip1 Mitf Krt1 Tcf7 Klf4 Aes Dkk4 Tcf4 Cby1 Hbp1 Myog Myf5 Btrc Jun Tbl1x Ar Sp5 Neurog1 Igf2bp1 Mdfic Cul1 Ccnd1 Ywhag Myc Ywhah Camk4 Sfn Cdh1 Mmp9 Ywhaz Xpo1 Ywhae Tle1 Ctnnb1 Cyr61 Hdac1 Apc Hdac2 Skp1a Ep300 Tert Ncoa2 Incenp Smarca4 Ywhab Axin2 Trrap PDGFR-BETA SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PDGFR-BETA SIGNALING PATHWAY PDGFR-beta signaling pathway Pdgfrb Mllt4 Mapk10 Slc9a3r2 Pik3cb Usp6nl Rps6ka3 Arhgap35 Cttn Ksr1 Eps8 Stat3 Hck Stat1 Prkcd Dnm2 Rhoa Map2k4 Prkca Pla2g4a Sipa1 Pag1 Myocd Sla S1pr1 Lrp1 Myc Arap1 Itgav Pin1 Slc9a3r1 Sphk1 Actn4 Jund Csk Wasl Ywhae Map2k1 Vav2 Rasa1 Ppp2r2b Rab4a Ppp2ca Tagln Elk1 Eif2ak2 Hras Dock4 Ppp2r1a Mapk9 Rap1b Sos1 Srf Prkce Abl1 Nck1 Pdgfb Nckap1 Arhgdia Lck Arpc3 Arpc2 Arpc1b Braf Bcar1 Fyn Pak1 Cyfip2 Rapgef1 Nck2 Rap1a Map2k7 Arpc5 Arpc4 Wasf2 Mapk1 Pten Ptpn2 Mapk8 Dok1 Fos Raf1 Shc1 Mapk3 Iqgap1 Abi1 Actr3 Actr2 Jun Grb10 Map2k2 Brk1 Ptprj Baiap2 Gab1 Ywhag Ywhah Nras Sfn Src Rac1 Ywhaz Kras Plcg1 Fgr Pik3cg Ptpn1 Ptpn11 Rab5a Cbl Pik3r6 Itgb3 Crk Yes1 Blk Pik3ca Pik3r1 Lyn Stat5a Ywhab Stat5b Jak2 Grb2 S1P4 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P4 PATHWAY S1P4 pathway Mapk1 Mapk3 Gnai3 Gnai2 Rhoa Gnai1 Gnaz Plcg1 S1pr4 S1pr5 Gna12 Gna13 Gnao1 GLYPICAN PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN PATHWAY Glypican pathway Gpc2 Gpc1 Gpc3 JNK SIGNALING IN THE CD4+ TCR PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%JNK SIGNALING IN THE CD4+ TCR PATHWAY JNK signaling in the CD4+ TCR pathway Crkl Mapk8 Crk Map3k8 Map4k1 Prkcb Lat Map3k7 Lcp2 Grap2 Dbnl Jun Map2k4 Map3k1 PLK1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLK1 SIGNALING EVENTS PLK1 signaling events Ect2 Gorasp1 Cdk1 Fbxw11 Spc24 Prc1 Ercc6l Golga2 Tpx2 Stag2 Fbxo5 Bub1b Bora Plk1 Kif2a Pak1 Cdc25c Cenpu Cdc20 Cdc14b Nudc Ppp1r12a Ninl Kif20a Wee1 Ppp2ca Clspn Ppp2r1a Aurka Bub1 Ndc80 Tubg1 Rock2 Kiz Cdc25b Btrc Ppp1cb Rhoa Fzr1 Cenpe Incenp Rab1 Sgol1 REGULATION OF CDC42 ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF CDC42 ACTIVITY Regulation of CDC42 activity Arhgap1 Itsn2 Arhgdia Arhgef9 Dock11 Itsn1 Arhgap17 Fgd1 Arhgef25 Spata13 Dock6 Dnmbp Mcf2 Dock10 Mcf2l Ralbp1 Vav2 Plcg1 Arhgef6 Arhgef7 Apc Git1 Vav3 Ngef Bcar3 Farp2 Racgap1 Nme1 FC-EPSILON RECEPTOR I SIGNALING IN MAST CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FC-EPSILON RECEPTOR I SIGNALING IN MAST CELLS Fc-epsilon receptor I signaling in mast cells Cblb Fyn Pak2 Map2k7 Akt1 Mapk1 Mapk8 Dok1 Vav1 Nfkb1 Fer Fos Raf1 Shc1 Chuk Mapk3 Jun Map2k4 Gab2 Map2k2 Pla2g4a Pld2 S1pr1 Btk Syk Ptk2 Ikbkb Sphk1 Lat Lcp2 Ikbkg Fcgr2b Map2k1 Rela Rasa1 Plcg1 Map3k1 Hras Ptpn11 Dusp1 Cbl Sos1 Prkcb Fcer1g Hcls1 Ms4a2 Pla2g1b Lat2 Wipf1 Pik3ca Pik3r1 Ppap2a Pxn Lyn Nfatc2 Ptpn13 Fcer1a Grb2 Itk BETA1 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA1 INTEGRIN CELL SURFACE INTERACTIONS Beta1 integrin cell surface interactions Itga3 Col2a1 Col7a1 Col6a3 Col6a2 Col6a1 Col3a1 Fgg Itga11 Itga8 Itga9 Itgb1 Itga1 Itga2 Thbs1 Itga4 Fn1 Vtn Lama1 Lama3 Plaur Itga5 Mdk Itgav Itga10 Itga7 Tnc Itga6 Lama5 Cspg4 Lama4 Lama2 Fbn1 Plau Lamc2 Igsf8 Cd81 Npnt Lamc1 Jam2 Lamb3 Lamb1 Nid1 Cd14 Lamb2 Vcam1 Spp1 Col11a2 Col1a2 F13a1 Col11a1 Col1a1 Tgm2 Col4a4 Fgb Tgfbi Vegfa Col4a6 Col5a1 Col4a5 Fga Col4a3 Col18a1 Col4a1 Col5a2 Thbs2 NONCANONICAL WNT SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NONCANONICAL WNT SIGNALING PATHWAY Noncanonical Wnt signaling pathway Camk2a Cthrc1 Chd7 Flna Nlk Dvl2 Dvl1 Setdb1 Daam1 Map3k7 Wnt5a Rac1 Mapk10 Arrb2 Dvl3 Csnk1a1 Rock1 Mapk8 Mapk9 Yes1 Fzd6 Rhoa Fzd5 Prkcz Fzd2 Ror2 Pparg Nfatc2 Tab1 Tab2 Fzd7 CXCR3-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CXCR3-MEDIATED SIGNALING EVENTS CXCR3-mediated signaling events Map2k3 Nras Mapk14 Rictor Src Pdpk1 Map2k1 Cxcl13 Ccl11 Arrb1 Cxcl11 Cxcl10 Kras Cxcr3 Cxcl9 Pf4 Pik3cb Hras Dnm1 Akt1 Mapk1 Raf1 Mapkap1 Mapk3 Gnai3 Gnai2 Mapk11 Gnai1 Pik3ca Mlst8 Pik3r1 Gnaz Mtor Map2k2 Gng2 Map2k6 Gnb1 Gnao1 NEUROTROPHIC FACTOR-MEDIATED TRK RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NEUROTROPHIC FACTOR-MEDIATED TRK RECEPTOR SIGNALING Neurotrophic factor-mediated Trk receptor signaling Tiam1 Rapgef1 Rap1a Bdnf Ntf5 Ntf3 Mapk1 Ntrk3 Ntrk2 Faim Nedd4l Matk Rgs19 Dnaja3 Shc1 Shc3 Rhog Stat3 Frs2 Frs3 Mapk3 Sqstm1 Rhoa Prkci Gipc1 Maged1 Gab2 Ngfr Dock1 Ntrk1 Gab1 Ccnd1 Elmo1 Nras Ngf Mcf2l Rac1 Map2k1 Kras Rasa1 Plcg1 Rasgrf1 Hras Dnm1 Ptpn11 Crkl Ehd4 Rap1b Rit2 Sos1 Rit1 Crk Abl1 Pik3ca Prkcz Pik3r1 Shc2 Grb2 AURORA C SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AURORA C SIGNALING Aurora C signaling Aurkb Incenp CELLULAR ROLES OF ANTHRAX TOXIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CELLULAR ROLES OF ANTHRAX TOXIN Cellular roles of Anthrax toxin Mapk1 Map2k3 Vcam1 Mapk3 Antxr1 Map2k1 Nlrp1a Il1b Il18 Map2k7 Pgr Antxr2 Map2k4 Tnf Map2k2 Map2k6 Casp1 SIGNALING EVENTS MEDIATED BY TCPTP%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY TCPTP Signaling events mediated by TCPTP Gab1 Ins2 Pdgfrb Hgf Src Met Csf1r Kdr Rab4a Pik3cb Eif2ak2 Ptpn1 Ptpn2 Jak3 Kpnb1 Sos1 Shc1 Stat3 Stat1 Crebbp Egfr Pdgfb Pias1 Pik3ca Itgb1 Itga1 Pik3r1 Csf1 Insr Vegfa Lman1 Egf Stat6 Stat5a Stat5b Jak1 Grb2 INSULIN-MEDIATED GLUCOSE TRANSPORT%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INSULIN-MEDIATED GLUCOSE TRANSPORT Insulin-mediated glucose transport Ywhag Ywhah Ins2 Gsk3b Stx4a Sfn Gys1 Ywhaz Rhoq Ywhae a Lnpep Trip10 Ppp1r3a Tbc1d4 Gm14226 Stxbp4 Ppp1cc Akt1 Akt2 Slc2a4 Prkci Prkcz Vamp2 Insr Ywhab RAS SIGNALING IN THE CD4+ TCR PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RAS SIGNALING IN THE CD4+ TCR PATHWAY Ras signaling in the CD4+ TCR pathway Mapk1 Map3k8 Braf Fos Raf1 Nras Prkcb Ptpn7 Mapk3 Map2k1 Kras Prkca Elk1 Hras COREGULATION OF ANDROGEN RECEPTOR ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%COREGULATION OF ANDROGEN RECEPTOR ACTIVITY Coregulation of Androgen receptor activity Fhl2 Med1 Casp8 Ccnd3 Cdk11b Tmf1 Pa2g4 Zfp318 Patz1 Cdk6 Pawr Nkx3-1 Kdm3a Tmprss2 Ncoa6 Cdkn2a Prdx1 Hnrnpa1 Fkbp4 Akt1 Snurf Ube2i Ctdsp1 Rps6ka3 Pias4 Tcf4 Pias1 Pias3 Ar Pelp1 Brca1 Ube3a Ccnd1 Prkdc Nrip1 Kdm1a Xrcc5 Ctnnb1 Gsn Xrcc6 Kdm4c Ranbp9 Hip1 Mak Tgfb1i1 Svil Carm1 Vav3 Appl1 Cmtm2b Lats2 Srf Ptk2b Tgif1 Zmiz1 Uba3 Ncoa2 VISUAL SIGNAL TRANSDUCTION: CONES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VISUAL SIGNAL TRANSDUCTION: CONES Visual signal transduction: Cones Slc24a2 Gngt2 Pde6h Gnb3 Grk1 Guca1a Guca1b Arr3 Gnb5 Rdh12 Rgs9 Rgs9bp Rdh5 Pde6c Gucy2e Cnga3 Lrat Cngb3 Gnat2 Gucy2f Rpe65 THROMBOXANE A2 RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%THROMBOXANE A2 RECEPTOR SIGNALING Thromboxane A2 receptor signaling Lck Fyn Nos3 Akt1 Rock1 Hck Arr3 Arhgef1 Sele Prkcd Ptgir Adrbk2 Mapk11 Rhoa Ptgdr Tbxa2r Plcb2 Prkca Syk Rab11a Slc9a3r1 Mapk14 Src Rac1 Adrbk1 Fgr Pik3cg Arrb2 Dnm1 Prkcq Pik3r6 Yes1 Prkcb Blk Prkce Prkcg Vcam1 Prkch Gnb5 Egfr Gnai2 Tgm2 Prkcz Lyn Gnaq Egf Gna11 Gna12 Gna13 Gng2 Gna14 Gnb1 Icam1 Gna15 Prkaca ALK2 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALK2 SIGNALING EVENTS ALK2 signaling events Smad5 Smad1 Bmp7 Tlx2 Smad9 Bmpr2 Acvr1 Fkbp1a Amhr2 Amh Smad4 A6B1 AND A6B4 INTEGRIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%A6B1 AND A6B4 INTEGRIN SIGNALING a6b1 and a6b4 Integrin signaling Ywhag Ywhah Sfn Cdh1 Met Rac1 Ywhaz Itga6 Ywhae Casp7 Mst1r Lama5 Cd9 Lama4 Mst1 Lama2 Col17a1 Pmp22 Erbb3 Hras Akt1 Il1a Lamc2 Lamc1 Lamb3 Lamb1 Itgb4 Erbb2 Lamb2 Shc1 Egfr Rxrg Pik3ca Itgb1 Rxrb Pik3r1 Rxra Prkca Egf Ywhab Lama1 Lama3 Grb2 P38 SIGNALING MEDIATED BY MAPKAP KINASES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P38 SIGNALING MEDIATED BY MAPKAP KINASES p38 signaling mediated by MAPKAP kinases Creb1 Etv1 Mapkapk3 Ywhag Lsp1 Ywhah Hspb1 Raf1 Srf Mapk14 Sfn Ywhaz Ywhae Cdc25b Mapk11 Tsc2 Th Tcf3 Ywhab Mapkapk2 POLO-LIKE KINASE SIGNALING EVENTS IN THE CELL CYCLE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%POLO-LIKE KINASE SIGNALING EVENTS IN THE CELL CYCLE Polo-like kinase signaling events in the cell cycle Plk3 Plk1 Plk2 Plk4 IL4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL4-MEDIATED SIGNALING EVENTS IL4-mediated signaling events Bcl6 Lta Oprm1 Hmga1 Cd40lg Aicda Ccl11 Egr2 Ccl17 Alox15 Sp1 Fcer2a Socs5 Socs1 Il2rg Mybl1 Dok2 Akt1 Socs3 Jak3 Cebpb Shc1 Irs1 Il4 Spi1 Myb Stat6 Jak1 Fes Ets1 Mapk14 Irs2 Ptpn6 Il13ra1 Il13ra2 Selp Cbl Arg1 Itgb3 Irf4 Retnlg Il4ra Gtf3a Il10 Parp14 Pigr Tff3 Col1a2 Col1a1 Pik3ca Pik3r1 Il5 Mtor Stat5a Stat5b Thy1 Jak2 Bcl2l1 Grb2 EPHRINB-EPHB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRINB-EPHB PATHWAY EphrinB-EPHB pathway Ephb3 Efnb2 Efnb1 Ephb2 Ephb1 Ephb4 TGF-BETA RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TGF-BETA RECEPTOR SIGNALING TGF-beta receptor signaling Pml Smad4 Smad2 Smurf1 Xiap Smurf2 Ppp2cb Axin1 Ppp2r2a Nedd4l Shc1 Dact2 Bambi Zfyve9 Smad7 Rnf111 Ppp1ca Dab2 Strap Tgfb3 Ctgf Ppp1r15a Eif2a Tgfbr3 Wwp1 Sptbn1 Yap1 Tab1 Zfyve16 Tab2 Daxx Dynlrb1 Camk2a Map3k7 Pdpk1 Ywhae Itch Ctnnb1 Ppp2ca Tgfbr1 Arrb2 Smad3 Sos1 Pard6a Cav1 Fkbp1a Tgfbr2 Tgfb1 Grb2 SIGNALING MEDIATED BY P38-ALPHA AND P38-BETA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING MEDIATED BY P38-ALPHA AND P38-BETA Signaling mediated by p38-alpha and p38-beta Eif4ebp1 Creb1 Mapkapk3 Hspb1 Mapk14 Usf1 Ptgs2 Ddit3 Krt8 Atf6 Trp53 Mknk1 Mef2a Mapkapk5 Gdi1 Esr1 Eif4e Cebpb Rab5a Mitf Slc9a1 Nos2 Ppargc1a Rps6ka4 Mef2c Hbp1 Rps6ka5 Elk4 Mapk11 Jun Atf2 Pla2g4a Mapkapk2 VALIDATED TRANSCRIPTIONAL TARGETS OF AP1 FAMILY MEMBERS FRA1 AND FRA2%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TRANSCRIPTIONAL TARGETS OF AP1 FAMILY MEMBERS FRA1 AND FRA2 Validated transcriptional targets of AP1 family members Fra1 and Fra2 Thbd Plaur Txlng Atf4 Dcn Ccnd1 Usf2 Ccl12 Dmtf1 Mmp1a Fosl2 Mgp Hmox1 Lif Jund Mmp9 Ccna2 Nfatc1 Sp1 Nos3 Gja1 Cdkn2a Plau Mmp2 Itgb4 Fosl1 Junb Ep300 Col1a2 Il6 Jun Nfatc3 Nfatc2 Lama3 SYNDECAN-1-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-1-MEDIATED SIGNALING EVENTS Syndecan-1-mediated signaling events Sdc1 Mmp1a Ccl5 Cask Hgf Met Mmp9 Hpse Fgfr4 Fgfr3 Fgf15 Ppib Bsg Col2a1 Lama5 Col7a1 Col6a3 Col6a2 Col6a1 Col3a1 Mapk1 Mapk3 Col11a2 Col1a2 Col11a1 Col1a1 Col4a4 Fgf23 Sdcbp Col4a6 Col5a1 Col4a5 Col4a3 Mmp7 Col4a1 Tgfb1 Prkaca Col5a2 IFN-GAMMA PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IFN-GAMMA PATHWAY IFN-gamma pathway Dapk1 Camk2a Camk2g Camk2b Map3k11 Camk2d Map2k1 Rapgef1 Rap1a Ifngr1 Socs1 Map3k1 Ifng Casp1 Akt1 Ptpn11 Mapk1 Crkl Ptpn2 Cbl Cebpb Rap1b Pias4 Stat3 Stat1 Mapk3 Prkcd Crebbp Smad7 Ep300 Irf1 Il1b Ptges2 Pias1 Pik3ca Pik3r1 Irf9 Mtor Jak2 Jak1 SYNDECAN-2-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-2-MEDIATED SIGNALING EVENTS Syndecan-2-mediated signaling events Tnfrsf13b Nf1 Gnb2l1 Bax Cask Ephb2 Src Fgfr4 Fgfr3 Fgf15 Csf2 Rasa1 Ezr Sdc2 Hras Mapk1 Mapk8 Mmp2 Mapk3 Prkcd Epb4.1 Casp3 Trappc4 Rhoa Fgf23 Sdcbp Itgb1 Kng2 Itga2 Fn1 Lama1 Cav2 Lama3 Tgfb1 Prkaca TRAIL SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TRAIL SIGNALING PATHWAY TRAIL signaling pathway Mapk1 Mapk8 Ikbkb Traf2 Chuk Ikbkg Mapk3 Tnfrsf10b Casp8 Smpd1 Pik3ca Pik3r1 Fadd Map2k4 Tnfsf10 Tradd Map3k1 Ripk1 Dap3 Cflar Pik3cb VALIDATED NUCLEAR ESTROGEN RECEPTOR BETA NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED NUCLEAR ESTROGEN RECEPTOR BETA NETWORK Validated nuclear estrogen receptor beta network Zfp709 Smarce1 Smarcb1 Ube2m Nr0b2 Ncoa1 Nedd8 Nr0b1 Uba3 Ncoa3 Ncoa2 C3 Smarca4 Esr2 Ddx54 SUMOYLATION BY RANBP2 REGULATES TRANSCRIPTIONAL REPRESSION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SUMOYLATION BY RANBP2 REGULATES TRANSCRIPTIONAL REPRESSION Sumoylation by RanBP2 regulates transcriptional repression Hdac1 Hdac4 Ube2i Pias1 Ran Mdm2 Ranbp2 Pias2 Xpo1 CASPASE CASCADE IN APOPTOSIS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CASPASE CASCADE IN APOPTOSIS Caspase cascade in apoptosis Srebf1 Bax Limk1 Pidd1 Casp8 Bid Birc3 Ripk1 Casp1 Xiap Apaf1 Diablo App Casp4 Casp2 Satb1 Dffa Dffb Acta1 Arhgdib Krt18 Top1 Casp6 Gas2 Casp9 Tfap2a Madd Numa1 Sptan1 Cradd Cfl2 Ptk2 Prf1 Lmnb2 Traf2 Lmna Gzmb Lmnb1 Casp7 Parp1 Birc2 Map3k1 Tnf Gsn Tnfrsf1a Vim Casp3 Bcl2 Tradd THROMBIN PROTEASE-ACTIVATED RECEPTOR (PAR) PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%THROMBIN PROTEASE-ACTIVATED RECEPTOR (PAR) PATHWAY Thrombin protease-activated receptor (PAR) pathway F2 S1P2 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P2 PATHWAY S1P2 pathway Mapk1 Cdh5 Mapk8 Fos Mapk14 S1pr2 Pak1 Irs1 Rac1 Mapk3 Gnai3 Gnai2 Rhoa Gnai1 Gnaz Jun Gnaq Gna11 Gna12 Gna13 Elk1 Gna14 Gna15 Gnao1 IL12-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL12-MEDIATED SIGNALING EVENTS IL12-mediated signaling events Lck Eomes Il1r1 Ccr5 Nfkb2 Tbx21 Il18r1 Ccl4 Relb Stat4 Hlx Fasl Il12rb1 Il12rb2 Socs1 Gzma Il2rg Il12b Il18rap Sphk2 Il12a Nfkb1 Il2rb Fos Il2ra H2-Eb1 Stat3 Stat1 Il4 Tyk2 Il1b Atf2 Il18 Stat6 Cd4 Map2k6 Map2k3 Gadd45g Rab7 Cd8b1 Gadd45b Mapk14 B2m Gzmb Cd247 Cd8a H2-Q10 Cd3d Cd3e Rela Cd3g Ripk2 Ifng Nos2 Mtor Il2 Stat5a Jak2 SPHINGOSINE 1-PHOSPHATE (S1P) PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SPHINGOSINE 1-PHOSPHATE (S1P) PATHWAY Sphingosine 1-phosphate (S1P) pathway Sgpl1 Sgpp1 S1pr1 S1pr2 Sphk1 Abcc1 S1pr3 Gnai3 Gnai2 Gnai1 Gnaz Gnaq S1pr4 Gna11 S1pr5 Gna12 Gna13 Gna14 Gna15 Sphk2 Gnao1 RHOA SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RHOA SIGNALING PATHWAY RhoA signaling pathway Map2k3 Slc9a3 Limk1 Pip5k1b Diap1 Limk2 Ppp1r12a Ezr Pip5k1c Cyr61 Myl2 Pten Rock1 Mapk8 Tln1 Fos Pip5k1a Vcl Srf Sh3gl2 Slc9a1 F2rl2 Pard6a Pkn2 Rock2 Cit Mkl1 Rdx Cdkn1b Rhoa Mapk12 Prkcz Msn Acta1 Jun Itgb1 Atf2 Pkn1 Scai Map2k4 Map2k6 Pld2 Pld1 VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL ACTIVATION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL ACTIVATION Validated targets of C-MYC transcriptional activation Bax Ruvbl2 Taf9 Smad4 Hmga1 Id2 Trp53 Tfrc Ccnd2 Rcc1 Myct1 Supt7l Eif4e Eif4g1 Mina Pdcd10 Ubtf Huwe1 Pfkm Cad Shmt1 E2f3 Taf4b Bmi1 Rpl11 Kat2a Fosl1 Gpam Ddx18 Ldha Prdx3 Lin28b Eif4a1 Ireb2 Cdk4 Mtdh Actl6a Serpini1 Ruvbl1 Bcat1 Hspa4 Polr3d Tk1 Nme1 Slc2a1 Ndufaf2 Supt3 Nbn Kat5 Eif2s1 Peg10 Hspd1 Odc1 Taf12 Myc Mmp9 Max Eno1 Cdc25a Hsp90aa1 Ak6 Smad3 Snai1 Npm1 Birc5 Eno1b Crebbp Ep300 Tert Mta1 Pim1 Trrap C-MYB TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%C-MYB TRANSCRIPTION FACTOR NETWORK C-MYB transcription factor network Wnt1 Nlk Ptgs2 Csf1r Birc3 Cdk6 Sp1 Cdkn1a Myod1 Cdkn2a Hes1 Ube2i Clta Lef1 Cebpb Copa Cebpa Ppp3ca Spi1 Iqgap1 Myb Pias3 Casp6 Cd4 Tab1 Tab2 Pax5 Cbx4 Lect2 Zfhx3 Ccnd1 Car1 Myc Ets1 Slc25a3 Tfec Nras Trim28 Mpo Ada Mat2a Mcm4 Map3k7 Hspa8 Ets2 Yeats4 Snd1 Elane Sin3a Gata1 Prtn3 Mad1l1 Ptcra Rag2 Adora2b Kras Ncor1 Hras Gata3 H2afz Crebbp Atp2b1 Ep300 Col1a2 Kitl Cd34 Cdkn1b Bcl2 Zfpm1 Ccna1 Kit Ski Maf Gstm2 Hipk2 Anpep Myf6 Pim1 Smarca2 Ppid CD40 CD40L SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CD40 CD40L SIGNALING CD40 CD40L signaling Myc Mapk14 Cblb Traf2 Map3k14 Cd40lg Birc3 Rela Mapk10 Tdp2 Birc2 Fcamr Traf6 Map3k1 Pik3cg Tnfaip3 Traf1 Pik3cb Traf3 Akt1 Cd40 Jak3 Mapk8 Mapk9 Nfkbia Pik3r6 Nfkb1 Il4 Mapk11 Pik3ca Jun Pik3r1 Map2k4 Stat5a Bcl2l1 REGULATION OF RAS FAMILY ACTIVATION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RAS FAMILY ACTIVATION Regulation of Ras family activation Nf1 Camk2b Nras Rasgrp1 Rasgrp2 Lgals1 Kras Rasa1 Rasgrf1 Hras Rras Plce1 Sos1 Sos2 Prkcb Prkce Rin1 Rasgrp3 Prkcz Lgals3 Dab2ip Prkca Rasa2 Rasa4 Rasgrp4 Rasal1 Rabgef1 Syngap1 Grb2 ALPHAE BETA7 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHAE BETA7 INTEGRIN CELL SURFACE INTERACTIONS AlphaE beta7 integrin cell surface interactions Cdh1 Itgb7 Itgae IL2 SIGNALING EVENTS MEDIATED BY STAT5%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL2 SIGNALING EVENTS MEDIATED BY STAT5 IL2 signaling events mediated by STAT5 Lck Myc Prf1 Lta Ccnd3 Ccna2 Fasl Cdk6 Sp1 Il2rg Ccnd2 Ptpn11 Jak3 Sos1 Il2rb Il2ra Shc1 Il4 Foxp3 Bcl2 Pik3ca Pik3r1 Elf1 Gab2 Il2 Stat5a Stat5b Jak1 Bcl2l1 Grb2 FOXO FAMILY SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXO FAMILY SIGNALING FoxO family signaling Rala Cat Bcl6 Zfand5 Ywhag Fbxo32 Ywhah G6pc Ikbkb Sirt1 Gadd45a Rbl2 Csnk1g2 Sfn Plk1 Ywhaz Xpo1 Ywhae Bcl2l11 Mapk10 Ctnnb1 Fasl Sod2 Kat2b Csnk1g1 Csnk1g3 Mst1 Csnk1d Usp7 Foxo4 Csnk1e Akt1 Csnk1a1 Skp2 Mapk8 Mapk9 Ralb Ran Sgk1 Chuk Cdk2 Foxo1 Crebbp Ep300 Cdkn1b Foxo3 Ywhab SIGNALING EVENTS MEDIATED BY HDAC CLASS II%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HDAC CLASS II Signaling events mediated by HDAC Class II Hdac4 Bcl6 Camk4 Hdac3 Xpo1 Ywhae Tubb2a Gata1 Adrbk1 Hsp90aa1 Tuba1b Esr1 Gata2 Ube2i Hdac10 Hdac6 Rfxank Hdac9 Hdac7 Bcor Ankra2 Srf Ran Hdac5 Mef2c Ranbp2 Nr3c1 Ywhab Ncor2 Gng2 Gnb1 Hdac11 CANONICAL WNT SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CANONICAL WNT SIGNALING PATHWAY Canonical Wnt signaling pathway Dvl3 Apc Wnt3a Axin1 Dvl2 Gsk3b Dvl1 Lrp6 Cul3 Pip5k1b Cav1 Klhl12 Nkd2 Fzd5 Ranbp3 Ctnnb1 Gsk3a Ppp2r5a Pi4k2a Csnk1g1 P73 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P73 TRANSCRIPTION FACTOR NETWORK p73 transcription factor network Cdk1 Pml Gnb2l1 Bax Sirt1 Ube4b Rb1 Nsg1 Rnf43 Pea15a Dedd Fas Gramd4 Cdk6 Gdf15 Fbxo45 Sp1 Aen Flot2 Cdkn1a Dcp1b Clca2 Hsf1 Il1rap Hagh Wwox Pfdn5 Rchy1 Bin1 Nedd4l Prkacb Afp Trp73 Cdk2 Casp2 Mapk11 Brca2 Yap1 Jak1 Kat5 Ntrk1 Chek1 Myc Pin1 Mapk14 Ada Sfn Hey2 Plk1 Bcl2l11 Fasn Ccna2 Serpina1a Itch Gata1 Bub3 Serpina1d Rad51 Ccne2 Rela Tuba1a Ndufs2 Mdm2 Jag2 Il4ra Bak1 Bub1 Abl1 Ep300 Ppap2a Plk3 Foxo3 Serpine1 Wt1 Trp63 CIRCADIAN RHYTHM PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CIRCADIAN RHYTHM PATHWAY Circadian rhythm pathway Chek1 Nono Cry1 Per2 Cry2 Timeless Npas2 Bhlhe40 Wdr5 Arntl Nr1d1 Clock Per1 Csnk1e BMP RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BMP RECEPTOR SIGNALING BMP receptor signaling Gsk3b Map3k7 Bmp4 Smad4 Sostdc1 Bmp2 Nog Ahsg Cer1 Smurf1 Smad5 Smad1 Fst Ctdspl Mapk1 Smurf2 Chrd Xiap Bmp7 Ppm1a Ctdsp1 Smad9 Bmpr2 Hfe2 Bmp6 Bmpr1b Bmpr1a Rgmb Rgma Smad6 Bambi Grem1 Smad7 Ppp1ca Nup214 Ppp1r15a Ski Tab1 Zfyve16 Tab2 ALK1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALK1 PATHWAY ALK1 pathway Acvr1 Acvrl1 Fkbp1a GLUCOCORTICOID RECEPTOR REGULATORY NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLUCOCORTICOID RECEPTOR REGULATORY NETWORK Glucocorticoid receptor regulatory network Creb1 Bax Tsg101 Pomc Tbx21 Cdk5r1 Trp53 Csf2 Mapk10 Pou2f1 Cdkn1a Fkbp4 Akt1 Mapk1 Mapk8 Tbp Fgg Nfkb1 Fos Prkacb Afp Sgk1 Mapk3 Nr3c1 Stat1 Spi1 Il4 Sele Mapk11 Il6 Jun Ppp5c Ywhah Gsk3b Mmp1a Il13 Mapk14 Krt5 Suv420h1 Sfn Nr1i3 Pbx1 Egr1 Fkbp5 Smarcc2 Smarcc1 Cga Nfatc1 Rela Hsp90aa1 Mdm2 Ifng Cdk5 Hdac1 Mapk9 Hdac2 Nr4a1 Gata3 Ncoa1 Csn2 Crebbp Pou1f1 Ep300 Pck2 Irf1 Vipr1 Ncoa2 Krt17 Krt14 Prl Smarcd1 Il5 Smarca4 Stat5a Il2 Stat5b Icam1 Prkaca EPHRIN A REVERSE SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRIN A REVERSE SIGNALING Ephrin A reverse signaling Epha5 Fyn Efna5 VALIDATED TRANSCRIPTIONAL TARGETS OF TAP63 ISOFORMS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TRANSCRIPTIONAL TARGETS OF TAP63 ISOFORMS Validated transcriptional targets of TAp63 isoforms Pml Cables1 Bax Ikbkb Gadd45a Ada Igfbp3 Plk1 Itga3 Itch Fdxr Egr2 Fas Gdf15 Aen Sp1 Flot2 Cdkn1a Jag1 Mdm2 Clca2 Cdkn2a Shh Nqo1 Gpx2 Spata18 Evpl Itgb4 Traf4 Ssrp1 Tfap2c Ogg1 Chuk Dhrs3 Dicer1 Hbp1 Smarcd3 Prkcd Mfge8 Perp Abl1 Ep300 Vdr Btrc Serpinb5 Wwp1 Trp63 REGULATION OF ANDROGEN RECEPTOR ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF ANDROGEN RECEPTOR ACTIVITY Regulation of Androgen receptor activity Gnb2l1 Rel Sirt1 Dnaja1 Spdef Appbp2 Hoxb13 Trim24 Pde9a Ehmt2 Kat7 Senp1 Nr2c1 Nr2c2 Zmiz2 Pou2f1 Kat2b Tmprss2 Mapk8 Rchy1 Cebpa Nr3c1 Foxo1 Jun Ar Map2k4 Map2k6 Kat5 Gsk3b Mapk14 Src Egr1 Smarcc1 Nr0b1 Mdm2 Hsp90aa1 Gata2 Hdac1 Smarce1 Carm1 Hdac7 Ncoa1 Crebbp Ep300 Rxrg Ncoa2 Rxrb Pkn1 Rxra Smarca2 BETA3 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA3 INTEGRIN CELL SURFACE INTERACTIONS Beta3 integrin cell surface interactions Plaur Sdc1 Ibsp Pecam1 Itgav Pdgfrb Sphk1 Tnc Edil3 Lama4 Fbn1 Kdr Cyr61 Plau Lamc1 Fgg Itgb3 Lamb1 Itga2b Spp1 Col1a2 Col1a1 Col4a4 Pdgfb Fgb F11r Tgfbi Thbs1 Col4a6 Vegfa Fga Col4a5 Fn1 Vtn Col4a3 Thy1 Sdc4 Tgfbr2 L1cam Col4a1 Cd47 EPHRINA-EPHA PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRINA-EPHA PATHWAY EphrinA-EPHA pathway Epha5 Epha4 Epha7 Epha3 Epha2 Epha6 Efna5 Epha8 DEGRADATION OF BETA CATENIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DEGRADATION OF BETA CATENIN Degradation of beta catenin Dvl3 Csnk1a1 Apc Cul1 Wnt3a Axin1 Dvl2 Gsk3b Dvl1 Lrp6 Skp1a Btrc Fzd5 Ctnnb1 Gsk3a Csnk1d Csnk1e Axin2 S1P1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P1 PATHWAY S1P1 pathway Mapk1 S1pr1 Pdgfrb Sphk1 Abcc1 Rac1 Mapk3 Ptgs2 Gnai3 Gnai2 Rhoa Pdgfb Gnai1 Gnaz Plcb2 Vegfa Plcg1 Kdr Gnao1 AP-1 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AP-1 TRANSCRIPTION FACTOR NETWORK AP-1 transcription factor network Cdk1 Creb1 Dmtf1 Atf3 Fosl2 Trp53 Csf2 Sp1 Trip6 Cdkn2a Pten Mafg Tcf7l2 Mt2 Agt Fos Cbfb Penk Fosb Bag1 Crtc1 Dmp1 Nppa Fosl1 Nr3c1 Cops5 Il4 Fabp4 Junb Nts Acta1 Il6 Jun Myb Atf2 Edn1 Elf1 Timp1 Ccnd1 Myc Ets1 Ccl12 Mmp1a Mmp9 Jund Egr1 Bcl2l11 Nfatc1 H2-Q10 Ctnnb1 Gja1 Ifng Cyr61 Esr1 Plau Gata2 Dusp1 Il10 Ep300 Col1a2 Cdkn1b Hif1a Th Il5 Nfatc3 Maf Nfatc2 Il2 Tgfb1 REGULATION OF RHOA ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RHOA ACTIVITY Regulation of RhoA activity Ect2 Arhgdia Trio Def6 Arap1 Arhgdig Arhgef25 Arhgef18 Arhgef2 Mcf2 Mcf2l Arhgap5 Vav2 Arhgef11 Arhgef12 Arhgef15 Bcr Arhgef3 Plekhg6 Arhgef17 Vav1 Arhgap35 Vav3 Arhgef10 Akap13 Ophn1 Arhgef28 Arhgap9 Arhgap8 Farp1 Ngef Net1 Arhgap6 Arhgef1 Arhgap4 Dlc1 Abr Cdkn1b Rhoa Arap3 Myo9b Srgap1 Arhgdib Arhgef10l AURORA A SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AURORA A SIGNALING Aurora A signaling Gadd45a Gsk3b Tpx2 Pak1 Ckap5 Ndel1 Tacc3 Trp53 Oaz1 Aurkaip1 Dlgap5 Rasa1 Mdm2 Cpeb1 Arhgef7 Ajuba Tdrd7 Akt1 Git1 Ppp2r5d Tacc1 Nfkbia Aurkb Aurka Ran Birc5 Cdc25b Cenpa Fzr1 Brca1 Prkaca INSULIN PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INSULIN PATHWAY Insulin Pathway Eif4ebp1 Exoc3 Ins2 Exoc6 Exoc5 Exoc4 Rhoq Pdpk1 Trip10 Rapgef1 Nck2 Rasa1 Hras Akt1 Ptpn1 Ptpn11 Akt2 Cbl Dok1 Grb14 Sos1 Sorbs1 Crk Sh2b2 Shc1 Sgk1 F2rl2 Irs1 Pard6a Cav1 Exoc1 Nck1 Prkci Prkcz Exoc2 Pik3ca Pik3r1 Insr Foxo3 Grb10 Exoc7 Ptpra Grb2 RETINOIC ACID RECEPTORS-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RETINOIC ACID RECEPTORS-MEDIATED SIGNALING Retinoic acid receptors-mediated signaling Cdk1 Mapk14 Nrip1 Hdac3 Kat2b Akt1 Mapk1 Hdac1 Mapk8 Prkcg Ccnh Rbp1 Rarg Ncoa1 Cdk7 Mapk3 Mnat1 Crebbp Ep300 Vdr Rxrg Ncoa3 Ncoa2 Rxrb Rxra Prkca Ncor2 Rara Rarb Prkaca IL1-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL1-MEDIATED SIGNALING EVENTS IL1-mediated signaling events Ube2n Ikbkb Map3k3 Il1r1 Map3k7 Ikbkg Rela Traf6 Il1rap Casp1 Il1a Mapk8 Erc1 Nfkb1 Chuk Irak4 Irak1 Ube2v1 Il1rn Il1b Sqstm1 Tollip Prkci Prkcz Pik3ca Jun Pik3r1 Irak3 Map2k6 Il1r2 Ticam2 Tab1 Tab2 Myd88 LKB1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LKB1 SIGNALING EVENTS LKB1 signaling events Creb1 Ywhag Ywhah Myc Gsk3b Sfn Mark2 Ctsd Smad4 Ywhaz Ywhae Mark4 Stk11ip Trp53 Psen2 Sik3 Brsk1 Sik2 Sik1 Hsp90aa1 Strada Stradb Stk26 Brsk2 Ezr Cdc37 Stk11 Crtc2 Esr1 Cab39 Etv4 Smarcd3 Akt1s1 Tsc2 Mlst8 Tsc1 Mtor Ywhab Rptor Prkaca GLYPICAN 2 NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN 2 NETWORK Glypican 2 network Mdk Gpc2 E2F TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E2F TRANSCRIPTION FACTOR NETWORK E2F transcription factor network Ces4a Pola1 Tfdp2 Yy1 Cdk1 Rybp Rrm2 Tyms Rbl2 Prmt5 Sirt1 Rrm1 Ces3b Tfe3 Ccne1 Uxt Ccnd3 Xrcc1 Rb1 Ranbp1 E2f6 Dhfr E2f5 E2f7 Mcm3 Sp1 Ces2h Cdkn1a Kat2b E2f4 Mybl2 Wasf1 Orc1 Cdkn2a Cdkn2c Ces1d Sult2a1 Ces5a Apaf1 E2f2 Atm Trp73 E2f3 Cdk2 Rbl1 Cebpa Hbp1 Kat2a Topbp1 Mcl1 Hic1 Tk1 Brca1 Myc Rbbp8 E2f1 Trim28 Casp7 Ccna2 Cdc25a Ccne2 Cdc6 Plau Hdac1 Cbx5 Rbbp4 Crebbp Ep300 Cdkn1b Tfdp1 Serpine1 Smarca2 Trrap IL23-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL23-MEDIATED SIGNALING EVENTS IL23-mediated signaling events Ccl12 Mpo Itga3 Il18r1 Stat4 Il12rb1 Cd3e Rela Cxcl9 Tnf Il12b Il18rap Ifng Alox12b Socs3 Il24 Cxcl3 Il17f Nfkbia Nfkb1 Il23r Il19 Nos2 Stat3 Stat1 Tyk2 Il1b Il6 Pik3ca Il18 Pik3r1 Stat5a Il2 Il17a Cd4 Il23a Jak2 TCR SIGNALING IN NAIVE CD4+ T CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TCR SIGNALING IN NAIVE CD4+ T CELLS TCR signaling in naive CD4+ T cells Lck Flna Fyn Rap1a Akt1 Pten Vav1 H2-Eb1 Shc1 Chuk Sh3bp2 Fyb Stk39 Was Sla2 Bcl10 Prkca Gab2 Cd4 Pag1 Trpv6 Cd86 Cd80 Ikbkb Nras Rassf5 Ptprc Lat Zap70 Malt1 Map3k14 Lcp2 Ikbkg Cd247 Csk Rasgrp1 Rasgrp2 Pdpk1 Orai1 Grap2 Dbnl Stim1 Cd3d Cd3e Cd3g Kras Plcg1 Traf6 Hras Ptpn6 Ptpn11 Cbl Prkcq Card11 Sos1 Map3k8 Map4k1 Prkcb Prkce Nck1 Grb2 Itk HYPOXIC AND OXYGEN HOMEOSTASIS REGULATION OF HIF-1-ALPHA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HYPOXIC AND OXYGEN HOMEOSTASIS REGULATION OF HIF-1-ALPHA Hypoxic and oxygen homeostasis regulation of HIF-1-alpha Tceb1 Os9 Gnb2l1 Vhl Naa10 Egln2 Egln3 Cops5 Trp53 Hif1a Arnt Rbx1 Hsp90aa1 Cul2 Hif1an Hif3a Cdkn2a HIF-1-ALPHA TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HIF-1-ALPHA TRANSCRIPTION FACTOR NETWORK HIF-1-alpha transcription factor network Creb1 Gck Hmox1 Smad4 Id2 Tfrc Sp1 Akt1 Hnf4a Ndrg1 Fos Igfbp1 Cops5 Ldha Bhlhe40 Jun Edn1 Cxcr4 Mcl1 Slc2a1 Ets1 Egln3 Furin Cxcl12 Eno1 Arnt Gata2 Itgb2 Smad3 Hdac7 Npm1 Nos2 Eno1b Ncoa1 Tff3 Eng Pkm Crebbp Pfkl Ep300 Pgk1 Bhlhe41 Abcg2 Car9 Nt5e Cp Hif1a Tert Ncoa2 Plin2 Adm Hk2 Aldoa Hk1 Trf Vegfa Abcb1a Fech Lep Serpine1 Epo Cited2 Pfkfb3 Pgm2 Rora EPO SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPO SIGNALING PATHWAY EPO signaling pathway Gab1 Btk Mapk14 Irs2 Rapgef1 Vav2 Rap1a Plcg1 Hras Ptpn6 Ptpn11 Epor Socs3 Crkl Plcg2 Mapk8 Cbl Sos1 Nfkb1 Shc1 Stat1 Tec Sh2b3 Bcl2 Pik3r1 Lyn Epo Stat5a Stat5b Jak2 Bcl2l1 Grb2 LPA4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LPA4-MEDIATED SIGNALING EVENTS LPA4-mediated signaling events Adcy9 Adcy8 Adcy7 Creb1 Adcy6 Adcy5 Adcy4 Adcy3 Prkce Rps6ka5 Adcy1 Adcy2 Gnal Lpar4 Prkaca NEPHRIN NEPH1 SIGNALING IN THE KIDNEY PODOCYTE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NEPHRIN NEPH1 SIGNALING IN THE KIDNEY PODOCYTE Nephrin Neph1 signaling in the kidney podocyte Fyn Bad Rac1 Wasl Nck2 Mapk10 Plcg1 Kirrel Pik3cb Arrb2 Akt1 Mapk8 Mapk9 Nphs2 Nphs1 Tjp1 F2rl2 Pard6a Nck1 Prkci Prkcz Cd2ap Pik3ca Jun Pik3r1 Map2k4 Trpc6 Grb2 ARF6 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF6 SIGNALING EVENTS Arf6 signaling events Acap1 Adap1 Arf6 Iqsec1 Hgf Ipcef1 Met Src Gulp1 Kif13b Cyth3 Arap2 Arrb1 Lhcgr Fbxo8 Acap2 Efna1 Arrb2 Adrb2 Git1 Itgb3 Epha2 Itga2b Egfr Nck1 Pxn Agtr1a Gnaq Cyth2 Egf Gna11 Tshr Gna14 Gna15 PAR1-MEDIATED THROMBIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PAR1-MEDIATED THROMBIN SIGNALING EVENTS PAR1-mediated thrombin signaling events Arhgdia Snx2 F2r Zyx Snx1 Vasp Arrb1 Nos3 F2 Myl2 Dnm1 Rock1 Akap13 Prkcb Prkcg F2rl2 Arhgef1 Prkcd Rock2 Gnai3 Dnm2 Gnai2 Adrbk2 Rhoa Gnai1 Pik3ca Pkn1 Gnaz Pik3r1 Plcb2 Prkca Gnaq Gna11 Trpc6 Plcb3 Gna12 Gna13 Gng2 Plcb1 Gna14 Gnb1 Gna15 Gnao1 E-CADHERIN SIGNALING IN THE NASCENT ADHERENS JUNCTION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E-CADHERIN SIGNALING IN THE NASCENT ADHERENS JUNCTION E-cadherin signaling in the nascent adherens junction Nckap1 Ccnd1 Ap1m1 Klhl20 Arf6 Cdh1 Src Cyfip2 Rac1 Mllt4 Tiam1 Rapgef1 Vav2 Rap1a Ctnnb1 Ctnnd1 Wasf2 Pip5k1c Dlg1 Akt1 Jup Rap1b Crk Tjp1 Cttn Itgb7 Ctnna1 Itgae Iqgap1 Abi1 Rhoa Pik3ca Pik3r1 Nme1 PRESENILIN ACTION IN NOTCH AND WNT SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PRESENILIN ACTION IN NOTCH AND WNT SIGNALING Presenilin action in Notch and Wnt signaling Kremen2 Fbxw11 Wnt1 Ccnd1 Ctbp1 Nlk Myc Gsk3b Dtx1 Dvl1 Notch1 Lrp6 Aph1b Map3k7 Adam10 Fzd1 Rbpj Tle1 Ctnnb1 Hnf1a Dkk1 Csnk1a1 Mapk1 Hdac1 Apc Ppp2r5d Nedd4 Axin1 Fos Aes Dll1 Mapk3 Crebbp Ncstn Psen1 Btrc Jun Wif1 Nkd1 Tab1 Ppard Dkk2 ALK1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALK1 SIGNALING EVENTS ALK1 signaling events Smad4 Acvrl1 Tgfbr1 Arrb2 Smad5 Smad1 Mapk1 Tlx2 Smad9 Bmpr2 Acvr1 Id1 Mapk3 Smad7 Eng Csnk2b Cav1 Ppp1ca Gdf2 Tgfb3 Acvr2b Inhba Acvr2a Fkbp1a Tgfbr2 Tgfb1 CLASS I PI3K SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CLASS I PI3K SIGNALING EVENTS Class I PI3K signaling events Lck Btk Syk Nras Adap1 Arf6 Blnk Lat Fyn Zap70 Src Rac1 Cyth3 Pdpk1 Inppl1 Rap1a Kras Hsp90aa1 Plcg1 Fgr Dapp1 Pik3cg Pik3cb Hras Pten Plcg2 Pik3r6 Yes1 Cyth1 Blk Sgk1 Hck Plekha2 Plekha1 Arf5 Rhoa Arap3 Pik3ca Pik3r1 Foxo3 Arf1 Lyn Cyth2 Itk E-CADHERIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E-CADHERIN SIGNALING EVENTS E-cadherin signaling events Jup Ctnnb1 Cdh1 CLASS IB PI3K NON-LIPID KINASE EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CLASS IB PI3K NON-LIPID KINASE EVENTS Class IB PI3K non-lipid kinase events Mapk1 Map2k1 Pik3r6 Pde3b Pik3cg IL27-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL27-MEDIATED SIGNALING EVENTS IL27-mediated signaling events Tbx21 Stat4 Il12rb1 Il12rb2 Tnf Il12b Ifng Il12a Il27 Il6st Il27ra Ebi3 Stat2 Gata3 Stat3 Stat1 Tyk2 Il1b Il6 Il18 Il2 Stat5a Il17a Jak1 Jak2 Tgfb1 PLK2 AND PLK4 EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLK2 AND PLK4 EVENTS PLK2 and PLK4 events Plk2 Plk4 PDGF RECEPTOR SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PDGF RECEPTOR SIGNALING NETWORK PDGF receptor signaling network Pdgfra Pdgfb Pdgfrb Pdgfd Pdgfc Pdgfa E-CADHERIN SIGNALING IN KERATINOCYTES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E-CADHERIN SIGNALING IN KERATINOCYTES E-cadherin signaling in keratinocytes Akt2 Jup Pip5k1a Zyx Fyn Cdh1 Src Ctnna1 Rac1 Egfr Vasp Rhoa Pik3ca Ctnnb1 Pik3r1 Ctnnd1 Plcg1 Casr Ajuba Akt1 REGULATION OF NUCLEAR SMAD2 3 SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF NUCLEAR SMAD2 3 SIGNALING Regulation of nuclear SMAD2 3 signaling Snip1 Foxh1 Creb1 Nkx2-5 Med15 Ifnb1 Ctbp1 Atf3 Foxg1 Cited1 Runx3 Tgif2 Tfe3 Irf7 Dlx1 Smad4 Smad2 E2f5 Sp1 Zbtb17 Kat2b Cdkn1a E2f4 Myod1 Foxo4 Akt1 Cebpb Hnf4a Fos Pias4 Cbfb Cdkn2b Cdk2 Rbl1 Kat2a Nr3c1 Foxo1 Smad7 Cdk4 Jun Pias3 Atf2 Ar Myc Hspa8 Sap30 Sin3b Max Sin3a Tcf3 Gm10094 Runx2 Ncor1 Esr1 Hdac1 Hdac2 Lamc1 Smad3 Itgb5 Rbbp4 Tgif1 Gata3 Mef2c Il10 Ncoa1 Skil Crebbp Dcp1a Vdr Ep300 Gsc Col1a2 Ncoa2 Il5 Foxo3 Ski Sp3 Tfdp1 Serpine1 Rbbp7 SIGNALING EVENTS MEDIATED BY PRL%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY PRL Signaling events mediated by PRL Mapk1 Rock1 Agt Rhoc Bcar1 Ccne1 Src Cdk2 Egr1 Rac1 Mapk3 Ccna2 Rhoa Itgb1 Itga1 Ptp4a3 Cdkn1a Ptp4a2 Atf5 Rabggtb Tuba1b Rabggta IL2-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL2-MEDIATED SIGNALING EVENTS IL2-mediated signaling events Lck Fyn Socs1 Il2rg Dok2 Mapk1 Socs3 Jak3 Mapk8 Il2rb Fos Il2ra Raf1 Shc1 Stat3 Cdk2 Irs1 Stat1 Mapk3 Mapk11 Rhoa Jun Gab2 Map2k2 Jak1 Mapkapk2 Syk Myc Mapk14 Nras Map2k1 Irs2 Kras Rasa1 Ifng Hras Ptpn11 Stam2 Mapk9 Stam Ikzf3 Socs2 Sos1 Prkcb Ptk2b Prkce Bcl2 Pik3ca Pik3r1 Cish Stat5a Il2 Stat5b Grb2 AMB2 INTEGRIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AMB2 INTEGRIN SIGNALING amb2 Integrin signaling Plaur Lrp1 Mmp9 Mst1r Rap1a Tnf Mst1 Plau Rock1 Selp Mmp2 Rap1b Jam2 Itgb2 Nfkb1 Tln1 Apob Selplg Hck Ager Itgam Jam3 Rhoa Il6 Ctgf Plg Thy1 Myh2 Icam1 Plat REGULATION OF RETINOBLASTOMA PROTEIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RETINOBLASTOMA PROTEIN Regulation of retinoblastoma protein Ctbp1 Sirt1 Ccne1 Hdac3 Met Ccnd3 Rb1 Csf2 Cdk6 Cdkn1a Myod1 E2f4 Cdkn2a Ccnd2 Tbp Cebpb Ubtf Mitf E2f2 Raf1 E2f3 Cdk2 Cebpa Spi1 Mapk11 Cdk4 Jun Atf2 Elf1 Cbx4 Suv39h1 Ckm Ccnd1 E2f1 Mapk14 Ccna2 Rbp2 Mdm2 Atf7 Sftpd Runx2 Dnmt1 Ppp2ca Aatf Pax3 Brd2 Taf1 Hdac1 Skp2 Smarcb1 Mapk9 Rbbp4 Mef2c Tgfb2 Crebbp Abl1 Ep300 Gsc Cdkn1b Smarca4 Pparg Tfdp1 SIGNALING EVENTS MEDIATED BY PTP1B%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY PTP1B Signaling events mediated by PTP1B Spry2 Lck Ins2 Pdgfrb Fyn Bcar1 Csf1r Akt1 Socs3 Dok1 Fer Shc1 Stat3 Hck Irs1 Tyk2 Rhoa Insr Txn1 Trpv6 Capn1 Ybx1 Lat Lepr Prlr Src Nox4 Csk Fgr Cdh2 Ptpn1 Itgb3 Crk Yes1 Blk Itga2b Egfr Csn2 Cav1 Pdgfb Pik3ca Pik3r1 Prl Csf1 Lyn Lep Egf Stat5a Fcgr3 Stat5b Jak2 Grb2 CERAMIDE SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CERAMIDE SIGNALING PATHWAY Ceramide signaling pathway Myc Bax Traf2 Ctsd Bad Casp8 Bid Map2k1 Birc3 Rela Pawr Fadd Ripk1 Map3k1 Tnf Eif2ak2 Sphk2 Tnfrsf1a Pdgfa Akt1 Mapk1 Mapk8 Nfkbia Nfkb1 Ksr1 Raf1 Mapk3 Prkcd Aifm1 Smpd3 Bcl2 Smpd1 Bag4 Prkcz Prkra Asah1 Map2k4 Tradd Map2k2 Egf Madd Cradd Map4k4 CLASS I PI3K SIGNALING EVENTS MEDIATED BY AKT%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CLASS I PI3K SIGNALING EVENTS MEDIATED BY AKT Class I PI3K signaling events mediated by Akt Ywhag Ywhah Akt3 Gsk3b Rictor Prkdc Sfn Src Bad Ywhaz Ywhae Pdpk1 Tbc1d4 Cdkn1a Hsp90aa1 Foxo4 Akt1 Akt2 Slc2a4 Raf1 Chuk Mapkap1 Foxo1 Kpna1 Cdkn1b Mlst8 Gsk3a Foxo3 Mtor Map3k5 Casp9 Ywhab Bcl2l1 Prkaca PLK3 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLK3 SIGNALING EVENTS PLK3 signaling events Chek2 Trp53 Plk3 Ccne1 Cdc25c INTEGRIN-LINKED KINASE SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTEGRIN-LINKED KINASE SIGNALING Integrin-linked kinase signaling Creb1 Ccnd1 Gsk3b Ruvbl2 Rictor Zyx Rac1 Xpo1 Lims2 Ckap5 Myl12a Tacc3 Parva Parvg Diap1 Elmo2 Parvb Nck2 Parp1 Ctnnb1 Ppp1r14b Hsp90aa1 Ppp1r12a Arhgef6 Ppp1r14c Ilkap Zeb1 Cdc37 Ppp1r14a Git2 Arhgef7 Tns1 Akt1 Aurka Snai1 Rhog Actn1 Iqgap1 Jun Pxn Ilk Ruvbl1 VALIDATED TRANSCRIPTIONAL TARGETS OF DELTANP63 ISOFORMS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TRANSCRIPTIONAL TARGETS OF DELTANP63 ISOFORMS Validated transcriptional targets of deltaNp63 isoforms Gnb2l1 Gsk3b Fosl2 Notch1 Adrm1 Ada Krt5 Igfbp3 Sfn Rrad Sec14l2 Rab38 Top2a Axl Dlx5 Fasn Itga3 Itch Bdkrb2 Stxbp4 Mdm2 Mre11a Cdkn2a T Fbxw7 Il1a Hes1 Gpx2 Tcf7l1 Atm Pou2f2 Nrg1 Ccnb2 Hells Hbp1 Perp Vdr Krt14 Ppp2r5a Col5a1 Brca2 Wwp1 Yap1 Trp63 DOWNSTREAM SIGNALING IN NAIVE CD8+ T CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DOWNSTREAM SIGNALING IN NAIVE CD8+ T CELLS Downstream signaling in naive CD8+ T cells Braf Eomes Stat4 Fasl Il2rg Mapk1 Mapk8 Il2rb Fos Il2ra Raf1 Fosl1 Mapk3 Junb Jun Prkca Map2k2 Ifnar2 Cd8b1 Prf1 Nras B2m Gzmb Ptpn7 Egr1 Cd247 Map2k1 Nfatc1 Cd8a H2-Q10 Cd3d Cd3e Cd3g Kras Tnf Elk1 Ifng Hras Tnfrsf18 Tnfrsf9 Ifna16 Mapk9 Prkcq Ifnar1 Egr4 Tnfrsf4 Prkcb Prkce Nfatc3 Nfatc2 Il2 LISSENCEPHALY GENE (LIS1) IN NEURONAL MIGRATION AND DEVELOPMENT%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LISSENCEPHALY GENE (LIS1) IN NEURONAL MIGRATION AND DEVELOPMENT Lissencephaly gene (LIS1) in neuronal migration and development Cdk5 Clip1 Ppp2r5d Pafah1b1 Katna1 Map1b Vldlr Reln Rac1 Ywhae Dync1h1 Dab1 Ndel1 Dcx Iqgap1 Abl1 Lrpap1 Cdk5r1 Rhoa Pafah1b3 Cdk5r2 Pla2g7 Pafah1b2 Nudc ERBB RECEPTOR SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB RECEPTOR SIGNALING NETWORK ErbB receptor signaling network Nrg3 Nrg4 Erbb4 Btc Erbb2 Areg Ereg Nrg1 Tgfa Hbegf Egfr Nrg2 Hsp90aa1 Egf Erbb3 EPHRIN B REVERSE SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRIN B REVERSE SIGNALING Ephrin B reverse signaling Lck Efnb2 Efnb1 Ephb2 Map3k7 Ephb1 Fyn Src Ephb4 Rac1 Tiam1 Nck2 Rgs3 Fgr Dnm1 Mapk8 Itgb3 Yes1 Blk Itga2b Hck Pik3ca Pik3r1 Map2k4 Lyn Ptpn13 P53 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P53 PATHWAY p53 pathway Yy1 Ube2d1 Prmt5 Csnk1g2 Trp53 Kat2b Csnk1g1 Csnk1g3 Csnk1d Usp7 Cdkn2a Csnk1e Akt1 Mapk8 Ppp2r4 E4f1 Rchy1 Mdm4 Dyrk2 Huwe1 Atm Ppp1r13l Ppm1d Rpl23 Ttc5 Smyd2 Kat8 Ccng1 Cdk2 Fbxo11 Rpl11 Setd8 Setd7 Prkcd Daxx Kat5 Chek1 Chek2 Pin1 Gsk3b Mapk14 Trim28 Rfwd2 Nedd8 Ccna2 Mdm2 Ppp2ca Csnk1a1 Skp2 Mapk9 Cse1l Crebbp Abl1 Ep300 Hipk2 FOXA1 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXA1 TRANSCRIPTION FACTOR NETWORK FOXA1 transcription factor network Xbp1 Ndufv3 Prdm15 Atp5j Ins2 Dscam Nrip1 Foxa3 Serpina1a Serpina1d Pou2f1 Sp1 Nkx3-1 Sftpd Foxa2 Shh Esr1 Cebpb Fos Foxa1 Apob Crebbp Ep300 Cdkn1b Ncoa3 Jun Gcg Nr2f2 Scgb1a1 Ar Sftpa1 Cyp2c55 Nfic Pisd Vtn Ap1b1 Nfia Brca1 Col18a1 PLASMA MEMBRANE ESTROGEN RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLASMA MEMBRANE ESTROGEN RECEPTOR SIGNALING Plasma membrane estrogen receptor signaling Nras Bcar1 Mmp9 Src Kras Nos3 Esr2 Hras Esr1 Akt1 Mmp2 Igf1r Sos1 Shc1 Hbegf Rock2 Gnai3 Gnai2 Mapk11 Rhoa Strn Msn Pik3ca Gnai1 Gnaz Pik3r1 Plcb2 Gnaq Pelp1 Gna11 Plcb3 Gng2 Gna13 Plcb1 Gna14 Gnb1 Gna15 Gnal Grb2 Gnao1 ENDOGENOUS TLR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ENDOGENOUS TLR SIGNALING Endogenous TLR signaling Tlr2 Tlr1 Hspd1 S100a9 Tlr3 Ikbkb Ly96 Cd14 Chuk Ikbkg Irak4 Irak1 Rhoa Sftpa1 Ticam1 Tirap Bgn Tlr4 S100a8 Vcan Myd88 Tlr6 Irak2 IL8- AND CXCR2-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL8- AND CXCR2-MEDIATED SIGNALING EVENTS IL8- and CXCR2-mediated signaling events Rab11a Rab7 Elmo1 Pdpk1 Rac2 Vasp Arrb1 Dock2 Cxcr2 Fgr Ppp2ca Pik3cg Dnm1 Ppp2r1a Arrb2 Akt1 Cbl Rab5a Pik3r6 Prkcb Prkcg Hck Gnai2 Plcb2 Lyn Prkca Plcb3 Gng2 Pld2 Gnb1 Gna14 Plcb1 Gna15 EGF RECEPTOR (ERBB1) SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EGF RECEPTOR (ERBB1) SIGNALING PATHWAY EGF receptor (ErbB1) signaling pathway Gab1 Ptk2 Nras Src Pak1 Wasl Nck2 Kras Rasa1 Plcg1 Pip5k1c Gsn Pik3cb Hras Ptpn1 Ptpn6 Ptpn11 Mapk1 Sos1 Tln1 Shc1 Stat3 Stat1 Mapk3 Egfr Gnai3 Nck1 Pik3ca Gnai1 Pik3r1 Egf Grb2 ATF-2 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATF-2 TRANSCRIPTION FACTOR NETWORK ATF-2 transcription factor network Creb1 Nf1 Atf3 Ins2 Ruvbl2 Rb1 Ddit3 Pou2f1 Dusp10 Dusp8 Hes1 Mapk1 Socs3 Pdgfra Mapk8 Mmp2 Fos Cbfb Ppargc1a Mapk3 Sele Junb Mapk11 Cdk4 Il6 Jun Atf2 Serpinb5 Prkca Il23a Brca1 Kat5 Ccnd1 Gadd45a Mapk14 Jund Ccna2 Ifng Esr1 Plau Dusp1 Dusp5 Mapk9 Arg1 Jdp2 Col24a1 Ache H2afy Hbb-bh1 Nos2 Csrp2 Hrk Tgfb2 Cul3 Ep300 Bcl2 Th Bcl2l1 ERBB4 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB4 SIGNALING EVENTS ErbB4 signaling events Nrg3 Nrg4 Erbb4 Btc Ereg Fyn Prlr Grin2b Itch Adam17 Nrg2 Mdm2 Ncor1 Pik3cb Wwox Lrig1 Mapk1 Nedd4 Erbb2 Nrg1 Shc1 Hbegf Mapk3 Dlg4 Pik3ca Cbfa2t3 Prl Pik3r1 Wwp1 Stat5a Stat5b Yap1 Jak2 Tab2 Grb2 ANGIOPOIETIN RECEPTOR TIE2-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ANGIOPOIETIN RECEPTOR TIE2-MEDIATED SIGNALING Angiopoietin receptor Tie2-mediated signaling Itga5 Ets1 Ptk2 Mapk14 Fgf2 Fyn Pak1 Rac1 Grb7 Tek Rela Cdkn1a Rasa1 Nos3 F2 Tnf Dok2 Elk1 Akt1 Ptpn11 Mapk1 Angpt1 Mapk8 Mmp2 Grb14 Nfkb1 Crk Shc1 Angpt4 Mapk3 Foxo1 Elf2 Bmx Nck1 Angpt2 Pik3ca Itgb1 Pik3r1 Pxn Elf1 Agtr1a Plg Stat5a Fn1 Stat5b Pld2 Grb2 Fes CALCINEURIN-REGULATED NFAT-DEPENDENT TRANSCRIPTION IN LYMPHOCYTES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CALCINEURIN-REGULATED NFAT-DEPENDENT TRANSCRIPTION IN LYMPHOCYTES Calcineurin-regulated NFAT-dependent transcription in lymphocytes Slc3a2 Egr3 E2f1 Ctla4 Ptprk Dgka Cblb Ikzf1 Rnf128 Egr1 Tbx21 Ptgs2 Batf3 Itch Cd40lg Nfatc1 Csf2 Egr2 Fasl Pou2f1 Tnf Ifng Ptpn1 Prkcq Egr4 Fos Il2ra Irf4 Gata3 Fosl1 Il4 Foxp3 Junb Casp3 Cdk4 Jun Il5 Pparg Maf Nfatc3 Nfatc2 Il2 FOXM1 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXM1 TRANSCRIPTION FACTOR NETWORK FOXM1 transcription factor network Chek2 Cdk1 Ccnd1 Myc Ccne1 Plk1 Xrcc1 Rb1 Ccna2 Map2k1 Gas1 Onecut1 Cenpf Sp1 Foxm1 Cks1b Nek2 Lama4 Cenpb Cdkn2a Etv5 Esr1 Skp2 Mmp2 Hspa1a Fos Aurkb Ccnb2 Birc5 Cdk2 Tgfa Crebbp Ep300 Cdc25b Cenpa Cdk4 Gsk3a Brca2 Nfatc3 IL8- AND CXCR1-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL8- AND CXCR1-MEDIATED SIGNALING EVENTS IL8- and CXCR1-mediated signaling events Pdpk1 Arrb1 Adrbk1 Fgr Pik3cg Dnm1 Arrb2 Cxcr1 Akt1 Cbl Rab5a Pik3r6 Prkcb Prkce Prkcg Hck Gnai2 Plcb2 Lyn Prkca Plcb3 Gng2 Gna14 Gnb1 Plcb1 Gna15 Pld1 EPHB FORWARD SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHB FORWARD SIGNALING EPHB forward signaling Ephb3 Itsn1 Ptk2 Efnb2 Synj1 Kalrn Efnb1 Nras Ephb2 Ephb1 Ephb4 Src Pak1 Rac1 Wasl Grb7 Map2k1 Rap1a Kras Rasa1 Hras Dnm1 Mapk1 Rock1 Rap1b Rras Efnb3 Crk Shc1 Mapk3 Efna5 Nck1 Pik3ca Pik3r1 Pxn Trf Grb2 Map4k4 SIGNALING EVENTS MEDIATED BY STEM CELL FACTOR RECEPTOR (C-KIT)%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY STEM CELL FACTOR RECEPTOR (C-KIT) Signaling events mediated by Stem cell factor receptor (c-Kit) Ptpro Spred2 Spred1 Pik3c2b Stap1 Socs1 Snai2 Akt1 Pten Mapk8 Dok1 Vav1 Matk Mitf Fer Sh2b2 Raf1 Shc1 Stat3 Stat1 Mapk3 Map2k2 Grb10 Gab1 Gsk3b Bad Pdpk1 Map2k1 Grap2 Hras Ptpn6 Ptpn11 Epor Crkl Cbl Sos1 Map4k1 Tec Sh2b3 Crebbp Kitl Bcl2 Pik3ca Pik3r1 Kit Foxo3 Lyn Stat5a Epo Jak2 Grb2 SIGNALING EVENTS MEDIATED BY HDAC CLASS I%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HDAC CLASS I Signaling events mediated by HDAC Class I Sirt3 Hdac4 Yy1 Sirt2 Fkbp3 Wdr77 Prmt5 Sirt1 Sirt7 Hdac3 Nr2c1 Kat2b Smurf1 Ube2i Nfkb1 Stat3 Smad7 Mbd2 Mta2 Hdac8 Btrc Tfcp2 Sirt5 Sirt4 Chd4 Chd3 Sirt6 Gatad2b Gatad2a Mbd3 Mxd1 Sap30 Sin3b Max Xpo1 Sin3a Gata1 Rela Gm10094 Tnf Ncor1 Tnfrsf1a Gata2 Hdac10 Hdac1 Hdac6 Hdac2 Nfkbia Hdac9 Hdac7 Ran Rbbp4 Hdac5 Ranbp2 Crebbp Ep300 Zfpm1 Smg5 Pparg Ncor2 Hdac11 Rbbp7 Prkaca ALTERNATIVE NF-KAPPAB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALTERNATIVE NF-KAPPAB PATHWAY Alternative NF-kappaB pathway Relb Btrc Nfkb1 Chuk Map3k14 Nfkb2 A4B7 INTEGRIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%A4B7 INTEGRIN SIGNALING a4b7 Integrin signaling Madcam1 Rhoa Ptk2 Itgb1 Pxn Itga4 Vcam1 Itgb7 TNF RECEPTOR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TNF RECEPTOR SIGNALING PATHWAY TNF receptor signaling pathway Map2k3 Gnb2l1 Ikbkb Map3k3 Traf2 Map3k7 Ikbkg Tnfrsf1b Casp8 Smpd2 Nrk Rffl Adam17 Map4k2 Birc3 Tnik Rela Fadd Map2k7 Birc2 Cyld Ripk1 Map3k1 Tnf Map4k5 Tnfaip3 Map4k3 Traf1 Tnfrsf1a Nsmaf Nfkb1 Chuk Stat1 Cav1 Sqstm1 Prkci Smpd1 Bag4 Prkcz Map3k5 Tradd Txn1 Madd Tab1 Tab2 Map4k4 C-MYC PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%C-MYC PATHWAY C-MYC pathway Kat5 Pml Taf12 Myc Pin1 Gsk3b Ruvbl2 Taf9 Pak2 Max Zbtb17 Cdkn2a Ppp2ca Fbxw7 Supt7l Skp2 Ak6 Axin1 Hbp1 Kat2a Actl6a Ppp2r5a Ruvbl1 Trrap Supt3 VEGF AND VEGFR SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VEGF AND VEGFR SIGNALING NETWORK VEGF and VEGFR signaling network Nrp1 Vegfb Figf Flt4 Vegfc Nrp2 Pgf Flt1 Vegfa Kdr ERBB2 ERBB3 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB2 ERBB3 SIGNALING EVENTS ErbB2 ErbB3 signaling events Nras Chrna1 Src Bad Rac1 Map2k1 Nf2 Mapk10 Kras Nrg2 Rnf41 Chrne Usp8 Dock7 Nfatc4 Pik3cb Hras Erbb3 Akt1 Ptpn11 Mapk1 Mapk8 Mapk9 Sos1 Fos Erbb2 Raf1 Nrg1 Shc1 Ppp3cb Stat3 Mapk3 Pik3ca Jun Pik3r1 Mtor Map2k2 Jak2 Grb2 Prkaca FGF SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FGF SIGNALING PATHWAY FGF signaling pathway Camk2a Plaur Spry2 Gab1 Cdh1 Fgfr1 Src Mmp9 Fgfr4 Fgfr3 Fgf15 Pdpk1 Ctnnd1 Plcg1 Runx2 Sdc2 Cdh2 Akt1 Plau Ptpn11 Mapk1 Cbl Sos1 Fos Cttn Ptk2b Shc1 Pak4 Frs2 Stat1 Mapk3 Ssh1 Spp1 Fgf23 Pik3ca Jun Klb Pik3r1 Fgfr2 Fgf1 Rps6ka1 Il17rd Ncam1 Stat5b Grb2 S1P5 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P5 PATHWAY S1P5 pathway Gnai3 Gnai2 Rhoa Gnai1 Gnaz Gna12 S1pr5 Gnao1 BARD1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BARD1 SIGNALING EVENTS BARD1 signaling events Nbn Rbbp8 Prkdc Ccne1 Fancf Fancg Fanca Fancc Fancl Xrcc5 Rad51 Trp53 Mre11a Xrcc6 Ube2d3 Rad50 Atm Pcna Cdk2 Ube2l3 Bard1 Cstf1 Ewsr1 Topbp1 Fancd2 Brca1 SIGNALING EVENTS MEDIATED BY FOCAL ADHESION KINASE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY FOCAL ADHESION KINASE Signaling events mediated by focal adhesion kinase Braf Fyn Bcar1 Pak1 Rapgef1 Nck2 Rap1a Arhgef7 Git2 Mapk1 Mapk8 Mapk8ip3 Rras Arhgap35 Vcl Raf1 Capn2 Rock2 Actn1 Rhoa Acta1 Jun Itgb1 Map2k4 Asap1 Dock1 Itga5 Ccnd1 Itgav Ptk2 Ets1 Elmo1 Src Rac1 Wasl Map2k1 Grb7 Rasa1 Plcg1 Arhgef11 Mapk9 Rap1b Sos1 Crk Tln1 Itgb5 Yes1 Ptpn21 Arhgap26 Arhgef28 Klf8 Sh3gl1 Bmx Nck1 Pik3ca Pik3r1 Pxn Grb2 GLYPICAN 1 NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN 1 NETWORK Glypican 1 network Lck Yes1 Fgf2 Nrg1 Blk Fyn Fgfr1 Src Hck Smad2 App Slit2 Serpinc1 Prnp Tgfb3 Flt1 Gpc1 Vegfa Lyn Fgr Lama1 Tgfbr2 Tgfbr1 Tgfb1 HIF-2-ALPHA TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HIF-2-ALPHA TRANSCRIPTION FACTOR NETWORK HIF-2-alpha transcription factor network Tceb1 Vhl Ets1 Sirt1 Egln2 Egln3 Twist1 Arnt Sp1 Eif3e Apex1 Hif1an Slc11a2 Fxn Kdr Mmp14 Elk1 Epas1 Adora2a Efna1 Pou5f1 Crebbp Ep300 Bhlhe40 Pgk1 Abcg2 Flt1 Vegfa Serpine1 Epo Cited2 Slc2a1 ALPHA6 BETA4 INTEGRIN-LIGAND INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA6 BETA4 INTEGRIN-LIGAND INTERACTIONS Alpha6 beta4 integrin-ligand interactions Lamc2 Lamc1 Lamb3 Lamb1 Itgb4 Lamb2 Lama5 Lama2 Lama1 Lama3 Itga6 SIGNALING MEDIATED BY P38-GAMMA AND P38-DELTA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING MEDIATED BY P38-GAMMA AND P38-DELTA Signaling mediated by p38-gamma and p38-delta Map2k3 Stmn1 Ccnd1 Mapk12 Pkn1 Mapk13 Snta1 Zak Map2k6 Eef2k UROKINASE-TYPE PLASMINOGEN ACTIVATOR (UPA) AND UPAR-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%UROKINASE-TYPE PLASMINOGEN ACTIVATOR (UPA) AND UPAR-MEDIATED SIGNALING Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling Plaur Itga5 Dock1 Lrp1 Itgav Pdgfrb Bcar1 Hgf Mmp9 Src Vldlr Rac1 Elane Itga3 Pdgfd Plau Fpr2 Mmp3 Ctrc Fpr1 Fpr3 Itgb2 Mmp13 Fgg Gpld1 Itgb3 Crk Klk4 Itgb5 Mmp12 Ctsg Itgam Egfr Fgb Itgb1 Plg Fga Fn1 Serpine1 Vtn Tgfb1 HEDGEHOG SIGNALING EVENTS MEDIATED BY GLI PROTEINS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HEDGEHOG SIGNALING EVENTS MEDIATED BY GLI PROTEINS Hedgehog signaling events mediated by Gli proteins Fbxw11 Gsk3b Csnk1g2 Sap30 Sin3b Xpo1 Sin3a Gli2 Map2k1 Ptch1 Csnk1g1 Csnk1g3 Gm10094 Csnk1d Csnk1e Foxa2 Shh Akt1 Arrb2 Csnk1a1 Hdac1 Hdac2 Rbbp4 Smo Prkcd Crebbp Stk36 Kif3a Gnai3 Ift88 Btrc Gnai2 Pias1 Gnai1 Gnaz Lgals3 Gli1 Gli3 Spop Rab23 Gng2 Ift172 Gnb1 Sufu Gnao1 Mtss1 Prkaca Rbbp7 REGULATION OF RAC1 ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RAC1 ACTIVITY Regulation of RAC1 activity Arhgap1 Dock1 Arhgdia Trio Arhgap17 Def6 Arhgef25 Kalrn Elmo1 Spata13 Dock6 Arhgef2 Mcf2 Rac1 Ralbp1 Prex1 Rap1gds1 Tiam1 Tiam2 Vav2 Dock2 Arhgef6 Rasgrf1 Arhgef7 Bcr Vav1 Sos1 Vav3 Eps8 Arhgap9 Ngef Abr Abi1 Racgap1 IL12 SIGNALING MEDIATED BY STAT4%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL12 SIGNALING MEDIATED BY STAT4 IL12 signaling mediated by STAT4 Cd86 Cd80 Prf1 Il13 Cd247 Tbx21 Il18r1 Stat4 Cd3d Cd3e Cd3g Etv5 Il18rap Ifng Mapk8 Mapk9 Fos H2-Eb1 Il2ra Stat3 Pias2 Crebbp Irf1 Jun Il18 Il2 Cd4 Tgfb1 HIV-1 NEF: NEGATIVE EFFECTOR OF FAS AND TNF-ALPHA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HIV-1 NEF: NEGATIVE EFFECTOR OF FAS AND TNF-ALPHA HIV-1 Nef: Negative effector of Fas and TNF-alpha Traf2 Map3k14 Cd247 Casp8 Casp7 Bid Birc3 Fas Fasl Rela Fadd Map2k7 Tnf Ripk1 Cflar Traf1 Tnfrsf1a Mapk8 Apaf1 Nfkbia Nfkb1 Chuk Casp2 Casp3 Bcl2 Bag4 Map3k5 Casp6 Tradd Casp9 Cradd Daxx WNT%NETPATH%WNT Wnt Dab2 Arhgef4 Rac1 Sox1 Tcf7l2 Prkaca Nlk Mark2 Wnt5b Kl Wnt5a Gsk3b Tcf4 Gsk3a Fzd5 Tcf3 Fzd2 Fzd3 Fzd1 Map2k4 Fzd8 Jup Setdb1 Src Ywhab Csnk1e Csnk1d Dkk1 Fzd6 Jun Dixdc1 Fzd7 Fzd4 Prkcd Ppp2ca Slc9a3r1 Ccnd1 Pparg Btrc Cdh1 Csnk1a1 Cdh2 Wnt9b Sfrp4 Fzd9 Gckr Bcl9 Pin1 Ppp1ca Lef1 Smad1 Nfatc2 Wnt3a Pi4k2a Lrp1 Mesdc2 Ctnnb1 Prkce Pip5k1b Gpc3 Sfrp1 Lrp6 Sfrp2 Prkca Wnt9a Lrp5 Map3k1 Chrna7 Prkcb Ilk Ryk Prkcg Prkcq Wnt7a Wnt7b Ppp1r1b Dvl2 Dvl3 Arrb1 Arrb2 Dvl1 Axin2 Axin1 Prkch Wif1 Rhoa Fzd10 Frat2 Map3k7 Mapk8 Map3k4 Rspo2 Cdk6 Ctbp2 Rspo3 Apc Raf1 Mapk1 Daam1 Kremen1 Chd7 Pax2 Rps6kb2 Wnt1 Wnt2 Wnt11 Wnt3 Wnt4 Wnt6 Akt1 Frzb Yes1 Ror1 Ror2 Ctbp1 Rspo1 Mapk3 EGFR1%NETPATH%EGFR1 EGFR1 Erbb3 Ptk2 Erbb2 Usp31 Ptk6 Pttg1ip Nedd9 Slc25a5 Dnm1 Ppp1r14b Epha4 Plec Otud6b Il17rd Nos3 Bad Dyrk1a Dynll1 Dyrk1b Scrib Ephb4 Ephb3 Ephb2 Ephb1 Stam2 Dab2 Sdc4 Sdc3 Map3k14 Cbl Map4k5 Magi1 Mtor Sh3bgrl Cd59b Antxr1 Hipk2 Jund Wasl Hipk3 Eno1b Ppp1r12a Arhgef7 Rab5a Siah2 Tfg Ubash3b Ppp2r3a Frs2 Frs3 Arhgef4 Pygb mt-Co2 Slc5a5 Afap1l2 Phpt1 Epha2 Epha1 Hnrnpr Zpr1 Hist1h3h Wnk1 Stx4a Wbp2 Rasa1 Krt5 Krt7 Pxn Kras Kit Ctnnd1 Flnb Tns4 Tns3 Tns2 Tns1 Pitpna Rac1 Adam9 Pten Arap1 Ldlr 2310030G06Rik Shb Casp9 Sh3kbp1 Pak1 Siah1a Stat5a Aplp2 Stat5b Pdgfrb Inppl1 Ripk1 Abl1 Abl2 Plekhn1 Git1 Scamp3 Snca S100a11 S100a10 S100a14 Pvrl1 Stat2 Tln1 Fyn Stat3 Stat1 Creb1 Tkt Cyld Phldb2 Caskin2 Acp1 Crkl Git2 Tfrc Slc12a7 Map2k3 Map2k2 Huwe1 Map2k1 Map2k5 Map2k7 Aldoa Pkn2 Krt8 Pdlim4 Rgs16 Tagln2 Krt6a Actr2 Sh2b1 Actr3 Hnrnpdl Prkaa1 Laptm4a Pik3ca Prkaa2 Atxn2 Pebp1 Axl Vasp Ptprr Insr Snx5 Hdac1 Cdh1 Cdh2 Cdh3 Eno1 Baiap2 Sirpa Smad3 Smad2 Cdkn3 Hgs Dsg2 Pdlim1 Itgb1 Foxo1 Pik3cd Pik3cg Plekha6 Bcar3 Limd1 Pik3cb Map3k3 Eif4ebp1 Plekha5 Eif4g1 Map3k1 Map3k2 Pfn1 Anks1 Zfyve16 Dlg3 Ptrf Cc2d1a Smu1 Cdk1 Arhgap5 Yjefn3 Lyn Cdk5 Sdpr Myl12b Itgb4 Rhoa Cdk2 Foxo4 Ctnnal1 Vcl Pard3 Plce1 Stk11 Rps6ka5 Ap2s1 Tnk2 Nck2 Mapk7 Mapk8 Dok1 Jak2 Plscr1 Stip1 Jak1 Actb Pdpk1 Eps8 Garem Egf Rfxank Pld1 Pld2 Rps6ka2 Rps6ka1 Rps6ka3 Bcar1 Nedd4 Map3k4 Hip1 Met Pias3 Dcbld2 Plcg1 Plcg2 Ralgds Krt17 Shc1 Krt18 Ahcyl1 Efnb2 Sdc1 Dapp1 Vim Trip6 Map4k1 Braf Mapk1 Ksr1 Rbck1 Stam Myc Nck1 Dok2 Mapk9 Flot1 Racgap1 Akt1 Flot2 Hspa4 Lck Myh9 Mapk3 Anxa2 Anxa1 Ap2a1 Anxa4 Ralbp1 Myo6 Dyrk4 Dyrk3 Gprc5a Src Cdv3 Ahnak Ptk2b Cblb Sri Ptpn1 Ptpn6 Ptpn5 Cblc Mta2 Erbb2ip Hras Sfpq Araf Pik3r3 Dusp1 Adam17 Mink1 Pik3r2 Pik3r1 Crk Cltc Iqgap1 Clta Ap2b1 Htt Epn3 Ncoa3 Csk Pkp4 Pkp3 Pkp2 Crim1 Klf11 Gsn Tollip Eef1a2 Ddx6 Grb14 Lsr Grb10 Rap1a Camk2a Eps15l1 Epn2 Epn1 Slitrk6 Eps15 Dsp Rps10 Mvp Alb Dock1 Atp5c1 Rictor Pik3c2b Frk Tgif1 Elmo2 Sos1 Sos2 Stxbp1 Sh2d3c Sp1 Abi1 Rps27l Cstb Bcl2 Cebpb Cebpa Cav1 Asap1 Mpzl1 Ptpra Cav2 Atp1a1 Marveld2 Mcf2 Tjp2 Usp6nl Elf3 Trp53 Etl4 Arf4 Ptpre Asap3 Rala Gja1 Ralb Arhgap35 Lpp Sh2d2a Cysrt1 Itch Ldha Itsn2 Raf1 Sdcbp Mapk14 Serpinb3d Arhgap42 Fos Spry1 Stambp Arhgap32 Cttn Esyt1 Nfkb1 Spry3 Spry2 Mprip Dock4 Socs1 Prkar1a Spry4 Socs3 Ctbp1 Gsk3b Gsk3a Reps1 Ptprf Ptpn18 Ptprk Reps2 Slc38a2 Jup Ywhab Grb2 Ensa Ptpn12 Jun Kirrel Ptpn11 Prkcd Actn1 Pkm Grb7 Sh3gl2 Prpf4b Snrpd2 Tnip1 Prkcz Ywhaz Ptpn23 Hnrnpa1 Irs2 Zdhhc5 Snx33 Khdrbs1 Pdcd6ip Vav2 Rela Hat1 Vav1 Errfi1 Egfr Col17a1 Pgam1 App Prkca Actn4 Prkci Prkcb Ddx3x Prkcg Baiap2l1 Tyk2 Phlpp1 Pdzd11 Adrbk1 Tom1l2 Prkx Tom1l1 Elk1 Appl1 Itga3 Appl2 Vav3 Gab2 Gab1 Rbbp7 Elk4 Ndufa13 Spg20 Rin1 Prkd1 RANKL%NETPATH%RANKL RANKL Ptk2 Prkaa1 Src Prkaa2 Jun Cblb Bad Ptpn6 Tnfrsf11b Etv5 Akt2 Tnfrsf11a Fcgr4 Chuk Hsp90aa1 Hspa5 Rel Hspa8 Spi1 Mitf Pik3r2 Nfkb2 Pik3r1 Cbl Syk Ikbkb Mtor Tab2 Ikbkg Rela Trem2 Tnfsf11 Relb Pilra Egfr Atf2 Tab1 Atp6v1e1 Eif4ebp1 Sirpb1b Map3k8 Sqstm1 Tyrobp Capn1 Nfatc1 Map2k6 Psmd14 Smarca4 Traf6 Traf3 Oscar Fhl2 Traf2 Traf1 Lyn Nfkbia Vav3 Gab2 Foxo4 Map3k7 Mapk8 Cebpb Jak1 Abl1 Plcg1 Plcg2 Fyn Mapk14 Stat1 Creb1 Cyld Mapk1 Rps6kb2 Nfkb1 Mapk9 Akt1 Map2k1 Map2k7 Mapk3 FSH%NETPATH%FSH FSH Grk4 Grk6 Hspb1 Src Prkaa2 Ptprr Akt2 Rps6ka3 Abl1 Mtor Foxo1 Gja1 Rela Egfr Eif4ebp1 Fyn Raf1 Mapk14 Creb1 Fshr Mapk1 Rara Prkaca Foxo3 Adrbk1 Arrb1 Arrb2 Cga Map2k2 Appl1 Arr3 Akt1 Map2k1 Mdm2 Plcd1 Prkar1a Tgm2 Hist1h3h Fshb Tsc2 Sgk1 Mapk3 TSH%NETPATH%TSH TSH Anxa1 Ptk2 Src Pik3ca Vasp Scrib Hras Hspa5 Prkcz Hspa8 Irs2 Pik3r2 Pik3r1 Ikbkb Slc16a1 Mtor Rb1 Cdk4 Rela Tshb Gnaq Bsg Ccnd3 Atf2 Kcnip3 Eif4ebp1 Prkca Slc2a1 Map2k6 Ppp1r1b Nfkbia Rhoa Cdk2 Igf1r Gnai3 Akt1s1 Apex1 Gnai1 Tshr Calr Gnai2 Gna12 Cdkn1b Lep Gna11 Jak2 Arf1 Gnao1 Gna13 Jak1 Tg Ctsb Pdpk1 Ccne1 Canx Nfkbib Atp1a1 Pde4d Rap1gap Rps6ka1 Ralgds Shc1 Raf1 Stat3 Stat1 Mapk14 Creb1 Mapk1 Prkaca Map2k3 Cga Akt1 Map2k1 Socs1 Socs3 Mapk3 TCR%NETPATH%TCR TCR Ptk2 Pttg1ip Nedd9 Dyrk1a Dyrk1b Chuk Stam2 Rel Map3k14 Cbl Syk Ikbkb Atf2 Arhgef7 Map3k8 Ubash3b Nfatc1 Traf6 Nfkbia Rasa1 Pxn Flnb Adam9 Shb Nfkbib Pak1 Stat5a Stat5b Abl1 Fyn Stat1 Creb1 Caskin2 Acp1 Crkl Git2 Tfrc Map2k2 Map2k1 Arhgef2 Epha3 Arhgef6 Trim25 Ctla4 Hsp90ab1 Cyfip1 Ldhb Crebbp Sla Mapk11 Pecam1 Cd5 Ptprc Dnm2 Pik3ap1 Vasp Atp1a3 Cd4 Cd2 Cd7 Nfam1 Gdi2 Cct8 Lat Tuba1a Diap1 Hnrnph3 Rapgef1 Actr10 Hgs Ppp3cb Elmo1 Dock2 Nfatc2 Ctnnb1 Map3k1 Prkcq Cdk1 Lyn Cd3g Cd3d Cd3e Itk Pag1 Dlg1 Pard3 Dnajb1 Cgn Arhgdib Rps6ka5 Sit1 Elp3 Icosl Acbd6 Mapk7 Rasgrp2 Mapk8 Nr4a1 Dok1 Pgm2 Rasgrp1 Sh3bp2 Ahcy BC005624 Dpysl2 G6pdx Ly9 Dtx1 Fyb Golga5 Sh2b3 Dgka Stk4 Lpxn Anxa11 Eno2 Hdac7 Evl Cabin1 Fcrl5 Homer3 Was Plcg1 Egr1 Plcg2 Lime1 Mtmr10 Stk39 Shc1 Eprs Inpp5d Lcp2 Cd247 Zap70 Grap2 Msl2 Cd2ap Map4k1 Def6 Lax1 Mapk1 Bmf Wipf1 Tsg101 Lnpep Dusp3 Nck1 Tec Dok2 Pi4ka Mapk9 Icos Bcl10 Unc119 Akt1 Wasf2 Sla2 Snrnp70 Lck Skap1 Skap2 Mapk3 Muc1 Ripk2 Malt1 Wdr1 Zdhhc17 Tuba4a Txnrd1 Slamf6 Cd84 Cd86 Bdh1 Cd82 Tubb5 Cd80 Ddx49 Eif3m Trat1 Txk Pstpip1 Ada Acly Ran Ptprh Fer Cd8a Grap Ogn Itpr1 Dbnl Acta1 Ptpn22 R3hcc1l Prkd2 Card11 Gsk3b Anxa2 Src Grb2 Cish Ptpn12 Ptk2b Jun Cblb Kirrel Ptpn11 Prkcd Ptpn6 Pkm Erbb2ip Prpf4b Stat4 Ywhaz Pik3r2 Jak3 Pik3r1 Crk Khdrbs1 Cltc Vav2 Rela Vav1 Pkp4 Pgam1 Ddx3x Rap1a Vav3 Gab2 Pik3c2b Sos1 Sos2 Sh2d3c Abi1 Cebpb Prkd1 Mpzl1 Ptpra Atp1a1 Arhgap35 Sh2d2a Itch Ldha Itsn2 Raf1 Sdcbp Mapk14 Fos Nfkb1 IL2%NETPATH%IL2 IL2 Mknk1 Il2rg Plcb1 Grb2 Tert Pik3ca Cish Ptk2b Nr3c1 Jun Il15 Il2 Ptpn11 Eif3b Bad Ptpn6 Il2rb Il2ra Vil1 Ets2 Itm2b Nmi Ybx1 Hsp90aa1 Stat4 Pik3r3 Stam2 Prkcz Irs2 Jak3 Pik3r2 Ets1 Pik3r1 Cbl Eif4e Crk Syk Irs1 Mtor Pik3cd Rela Pik3cg Vav1 Atf2 Pik3cb Eif4ebp1 Lyn Elk1 Gab2 Cdk2 Sos1 Mapk8 Jak2 Bcl2 Jak1 Ccne1 Shb Stat5a Stat5b Shc1 Raf1 Fyn Stat3 Stat1 Mapk14 Creb1 Mapk1 Foxo3 Stam Crkl Nfkb1 Map2k2 Akt1 Map2k1 Socs1 Lck Socs3 Sgk1 Mapk3 LEPTIN%NETPATH%LEPTIN Leptin Gsk3b Gsk3a Ptk2 Erbb2 Hspb1 Sh2b1 Prkaa1 Src Grb2 Cish Prkaa2 Nos3 Ptpn11 Bad Mapkapk2 Prkcd Cd44 Gap43 Socs7 Pde3a Pdia3 Chuk Irs4 Crp Prkcz Socs2 Rel Slc2a4 Irs2 Jak3 Pik3r2 Mmp14 Pik3r1 Eif4e Itgb5 Esr1 Irs1 Khdrbs1 Ikbkb Mtor Foxo1 Ikbkg Rela Gnaq Prkce Atf2 Egfr Eif4ebp1 Map2k6 Elk1 Cdk5 Nfkbia Igf1r Sp1 Mapk8 Lep Jak2 Pten Jak1 Hspb2 Rps6ka2 Stat5a Rps6ka1 Stat5b Plcg1 Plcg2 Acaca Acacb Shc1 Sp3 Runx2 Ncoa1 Raf1 Limk1 Fyn Cfl2 Stat3 Mapk14 Stat1 Ep300 Creb1 Prkab1 Prkab2 Lepr Mapk1 Nfkb1 Map2k3 Map2k2 Akt1 Map2k1 Lck Socs3 Mapk3 IL1%NETPATH%IL1 IL1 Gsk3b Map2k4 Jun Ptpn11 Chuk Prkcz Rel Sirpa Pik3r2 Map3k14 Pik3r1 Irs1 Ikbkb Irak4 Tab2 Rb1 Irak3 Ikbkg Rela Peli2 Eif2s1 Atf2 Tab1 Map3k3 Sqstm1 Map3k2 Tollip Map2k6 Traf6 Nfkbia Map3k7 Il1r1 Pla2g4a Il1r2 Eif2ak3 Ecsit Mapk8 Dok1 Ikbkap Il1rn Irak2 Peli1 Tab3 Nfkbib Irak1 Fbxw5 Hspb2 Ppp6c Myd88 S100b Ube2v1 Il1b Il1a Ube2n Il1rap Plcg1 Stat3 Mapk14 Mapk1 Nfkb1 Map2k3 Mapk9 Map2k2 Akt1 Map2k1 Map2k7 Mapk3 ID%NETPATH%ID ID Tcf4 Tcf3 Elk4 Elk3 Pax8 Myod1 Ets2 Atf3 Id3 Id4 Pax5 Srebf1 Smad3 Rb1 Hes1 Myog Smurf2 Olig1 Olig2 Psmd4 Rbl2 Rbl1 Raf1 Myf5 Tcf12 Id2 Id1 Myf6 Mapk1 Tcf7l2 Pax2 Fhl2 Elk1 Map2k2 Map2k1 Cdk2 Mapk3 NOTCH%NETPATH%NOTCH Notch Gsk3b Tcf3 Src Furin Bloc1s1 Skp2 Mef2c Hdac1 Adam17 Smad3 Pik3r2 Pik3r1 Lef1 Smad1 Rela App Jak2 Maml1 Maml2 Yy1 Mfng Dtx1 Numb Notch4 Rbx1 Cul1 Psen2 Psen1 Lfng Fhl1 Adam10 Hdac2 Wdr12 Aph1b Ncstn Hes1 Fbxw7 Pofut1 Hes5 Hes6 Itch Notch3 Notch2 Notch1 Ncor2 Stat3 Jag1 Ep300 Jag2 Ring1 Ncor1 Mapk1 Cir1 Nov Skp1a Dll1 Numbl Maml3 Nfkb1 Dll4 Hey2 Ascl1 Cntn1 Akt1 Sap30 Rbpj Spen Lck Sin3a Dll3 Mapk3 Kat2b TGF_BETA_RECEPTOR%NETPATH%TGF_BETA_RECEPTOR TGF_beta_Receptor Ptk2 Cd44 Chuk Dab2 Hspa8 Ikbkb Esr1 Mtor Jund Atf2 Tab1 Map2k6 Traf6 Nfkbia Pxn Ccne1 Runx2 Ncoa1 Ep300 Foxo3 Map2k3 Map2k2 Map2k1 Tcf4 Trap1 Zeb1 Crebbp E2f5 Hoxa9 Pik3ca Dcp1a Mef2a Gipc1 Zeb2 Prkar1b Ppp2ca Trim33 Ewsr1 Ccnd1 Stk11ip Hdac1 Sik1 Trp73 Btrc E2f4 Prkar2a Foxh1 Ctcf Dync1i1 Smad3 Pdk1 Smad2 Sdc2 Med15 Hgs Lef1 Fosb Sptbn1 Foxg1 Itgb1 Acvrl1 Foxo1 Pias1 Tgfb3 Rnf111 Ctnnb1 Tgfb2 Strap Tgfb1 Ppp1r15a Yap1 Eif4ebp1 Nme1 Stambpl1 Uchl5 Rock1 Ppm1a Pias2 Eng Zfyve16 Wwtr1 Ddx5 Anapc7 Camk2d Camk2b Cdk1 Pja1 Ctnna1 Arrb2 Ctnna2 Dvl1 Runx3 Axin2 Camk2g Axin1 Wwp1 Anapc5 Klf10 Rhoa Anapc4 Cdk2 Anapc2 Foxo4 Map3k7 Anapc1 Cited1 Tgfbr3 Kpnb1 Pard3 Nup153 Tgfbr1 Stk11 Tgfbr2 Rps6ka5 Csnk1g2 Ube2d1 Vdr Brca1 Tfdp2 Mapk8 Tfdp1 Cops5 Ube2d3 Itgb3 Smurf1 Sparc Daxx Pdpk1 Cdc23 Skil Cdc27 Snip1 Cdc16 Ar Nfyb Nfyc Ccnb2 Nfya Bcar1 Anapc10 Cdkn1a Fkbp1a Samd3 Smad4 Cdk6 Vps39 Smad6 Smad7 Snx4 Snx2 Eid2 Shc1 Nup214 Cdc25a Ppp1cc Hnf4a Snx1 Ing2 Ppp2r1a Zfyve9 Map4k1 Snx6 Ppp2r2a Mapk1 Dynlrb2 Dynlrb1 Ube2i Xpo1 Myc Xpo4 Fnta Nedd4l Junb Irf2bp1 Sox9 Akt1 Ski Fzr1 Eif3i Pml Pard6a Mapk3 Gsk3b Src Grb2 Jun Mef2c Atf3 Erbb2ip Pik3r2 Ets1 Pik3r1 Crk Rb1 Cdk4 Ap2b1 Smurf2 Olig1 Rbl2 Rbl1 Camk2a Tgif1 Sos1 Sp1 Cav1 Rbx1 Cul1 Trp53 Itch Raf1 Mapk14 Fos Skp1a Nfkb1 Kat2b IL4%NETPATH%IL4 IL4 Ptk2 Il2rg Crebbp Grb2 Pik3ca Mapk11 Ptpn11 Bad Ptpn6 Prkcd Chuk Prkcz Spi1 Irs2 Pik3r2 Jak3 Cbl Pik3r1 Ets1 Syk Irs1 Ikbkb Pik3cd Rela Ncoa3 Atf2 Tyk2 Elk1 Nfkbia Hist1h3h Gab2 Rasa1 Sos1 Mapk8 Jak2 Cebpb Cebpa Jak1 Stat5a Stat5b Cxcr4 Plcg1 Plcg2 Snd1 Socs5 Shc1 Fes Hist2h3c1 Inpp5d Fyn Stat3 Stat1 Ep300 Mapk14 Mapk1 Il13ra1 Stam Nfkb1 Dok2 Il4ra Bcl2l1 Akt1 Btk Socs1 Stat6 Cd40 Lck Il4 Socs3 Adrbk2 Mapk3 Il13 ANDROGENRECEPTOR%NETPATH%ANDROGENRECEPTOR AndrogenReceptor Ptk2 Ppp1r14a Hdac1 Hspb1 Ar Akt1 Creb1 Pik3r1 IL3%NETPATH%IL3 IL3 Gsk3b Gsk3a Ptk2 Hspb1 Dnm1 Ywhab Src Grb2 Cish Ptprc Ptpn11 Bad Ppp2ca Ptpn6 Hras Socs2 Ywhaz Rapgef1 Pik3r2 Cbl Pik3r1 Crk Syk Foxo1 Rb1 Pik3cd Vav1 Atf2 Kcnip3 Prkca Prkcb Slc2a1 Tyk2 Lyn Gab2 Gab1 Vcl Pxn Sos1 Mapk8 Dok1 Jak2 Bcl2 Jak1 Hck Bcl2l11 Csf2rb2 Rxra Pilrb1 Pak1 Stat5a Ppp3ca Gata2 Stat5b Gata1 Fcer1g Bax Gnb2l1 Il3ra Shc1 Fes Inpp5d Raf1 Fyn Stat3 Mapk14 Creb1 Mapk1 Rara Prkaca Foxo3 Crkl Nfkb1 Dok2 Tec Bcl2l1 Akt1 Map2k1 Lck Socs3 Mapk3 ALPHA6BETA4INTEGRIN%NETPATH%ALPHA6BETA4INTEGRIN Alpha6Beta4Integrin Ptk2 Erbb2 Ywhab Src Grb2 Pik3ca Plec Jun Ptpn11 Bad Prkcd Erbb2ip Trp73 Ephb2 Pik3r3 Ywhaz Smad3 Smad2 Pik3r2 Irs2 Pik3r1 Eif4e Irs1 Ntn1 Mtor Lama1 Pik3cd Lama3 Pik3cg Mst1r Lamb2 Lamb3 Egfr Casp3 Pik3cb Col17a1 Lamb1 Eif6 Eif4ebp1 Ywhah Lamc1 Prkca Rtkn Lamc2 Clca1 Clca2 Ywhae Cd151 Dsp Rpsa Sfn Itgb4 Mylk3 Rhoa Itga6 Lama2 Gab1 Lama5 Rac1 Pak1 Ar Abl1 Met Shc1 Fyn Vim Mapk14 Fos Mapk1 Akt1 Yes1 Mapk3 HEDGEHOG%NETPATH%HEDGEHOG Hedgehog Crebbp Shh Dyrk1a Sdc2 Smad1 Gas1 Med6 Hhat Cdk8 Ctnnb1 Sufu Ihh Med12 Boc Gli1 Cdon Gli2 Gli3 Nr2e1 Ptch1 Ptch2 Ywhae Dhh Prkaca Adrbk1 Arrb2 Med1 Hhip Kif27 Akt1 Smo Ski Stk36 Med23 Sin3a Gm10094 Rab23 KITRECEPTOR%NETPATH%KITRECEPTOR KitReceptor Bad Mitf Cbl Mtor Atf2 Rasa1 Kit Hck Csf2rb2 Sh3kbp1 Pak1 Fer Stat5a Grap Stat5b Abl1 Socs5 Fes Fyn Stat3 Ep300 Stat1 Foxo3 Crkl Map2k2 Btk Map2k1 Gsk3b Gsk3a Actr2 Src Grb2 Pik3ca Cblb Jun Ptpn11 Ptpn6 Grb7 Hras Lat Jak3 Pik3r2 Pik3r1 Crk Cltc Nfatc2 Rela Vav1 Msn Eif4ebp1 Tnfrsf10b Prkca Mad2l1 Mapk12 Rdx G3bp1 Prkcb Socs6 Socs4 Grb10 Elk1 Lyn Gab2 Cdk2 Sos1 Mapk8 Dok1 Jak2 Sh2b2 Mpdz Fgr Il7r Ptpru Rab7 Fyb Spred1 Spred2 Sh2b3 Stap1 Gys1 Rps6ka1 Dok3 Epor Matk Ezr Kitl Was Plcg1 Plcg2 Shc1 Inpp5d Raf1 Mapk14 Mapk1 Wipf1 Dok2 Tec Akt1 Socs1 Yes1 Skap2 Mapk3 IL-7%NETPATH%IL-7 IL-7 Gsk3b Gsk3a Il2rg Ptk2b Cblb Jak1 Bad Il7r Stat5a Stat5b Irs2 Jak3 Pik3r1 Cltc Irs1 Foxo1 Il7 Shc1 Fyn Stat3 Stat1 Mapk1 Foxo3 Stam Map2k2 Map2k1 Akt1 Mapk3 TNFALPHA%NETPATH%TNFALPHA TNFalpha Erbb3 Ptk2 Erbb2 Hspb1 Mapkapk2 Akt2 Tnfrsf11a Chuk Hsp90aa1 Hspa5 Rel Hspa8 Map3k14 Nfkb2 Syk Ikbkb Mtor Tab2 Ikbkg Relb Casp3 Tab1 Ppp1r12a Ywhah Map3k8 Map2k6 Ywhae Smarca4 Traf6 Traf3 Traf2 Traf1 Nfkbia Hist1h3h Ikbkap Rxra Tab3 Casp9 Nfkbib Pak1 Ppp6c Stat5a Bax Ripk1 Gnb2l1 Ep300 Stat1 Creb1 Bcl2l1 Map2k1 Map2k5 Map2k7 Arhgef2 Trap1 Hsp90ab1 Map2k4 Crebbp Hdac1 Btrc Pdk1 Smad3 Smad2 Foxo1 Prkce Map3k3 Map3k1 Map3k2 Prkcq Cdk5 Map3k7 Rps6ka5 Mapk8 Dok1 Cops5 Ube2d3 Pias3 Mapk1 Ube2i Mapk9 Junb Akt1 Pml Mapk3 Pdcd2 Nkiras1 Nkiras2 Madd Trappc9 Tnip2 Casp8 Casp7 Trib3 Zfand5 Ccnt1 Casp2 Peg3 Unc5cl Ywhag Glb1 Bid Nfkbie Nsmaf Dpf2 Rasa3 Flna Hdac6 Psmd13 Myl2 Pkn1 Tank Fadd Tbkbp1 Txnip Psmd12 Tax1bp1 Tradd Nlrp4e Rfk Traf4 Fancd2 Traf7 Fbl Ripk3 Rpl4 Smpd3 Zbtb17 Tnfrsf8 Psmd3 Psmd2 Tnfaip3 Tnf Commd1 Txlna Glul Cops3 Polr1a Polr1c Polr1b Iqgap2 Psmd1 Map3k5 Psmd7 Psmd6 Kpna3 Kpna6 Smarcb1 Polr1e Rasal2 Polr1d Romo1 Irak1bp1 Papola Rps11 Smarcc1 Psmb5 Fkbp5 Smarcc2 Eed Spag9 Polr2h Dcaf7 Mylk Tnfrsf1b Traip Rnf25 Faf1 Nfkbiz Myl12a Actl6a Smarce1 Prc1 Alpl Tnfrsf1a Mcm7 Rffl Mcm5 Diablo Cdc37 G3bp2 Cdk9 Mark2 Ktn1 Hspa1a Sec16a Glg1 Psmc3 Psmc1 Psmc2 Mtif2 Rnf11 Cdc34 Trpc4ap Ywhab Src Tbk1 Grb2 Fbxw11 Jun Ptpn11 Prkcd Prkcz Ywhaz Irs2 Pik3r2 Pik3r1 Irs1 Brinp1 Tifa Rb1 Map3k11 Rela Cryab Cflar Cradd Lrpprc Egfr Akap8 Bcl7a Txn1 Usp2 Prkca Nr2c2 Map4k2 Cyba Usp11 Ddx3x Bcl3 Otud7b Apaf1 Pygl Gtf2i Xiap Arhgef1 Nupr1 Pfdn2 Ikbke Bag4 Trim32 Copb2 Kcnq1 Ppp1r13l Birc3 Gab1 Birc2 Sos1 Sos2 Cav1 Cul1 Trp53 Hdac2 Fbxw7 Itch Mapk14 Skp1a Nfkb1 IL9%NETPATH%IL9 IL9 Vcp Il9r Shc1 Il2rg Grb2 Stat3 Stat1 Kat5 Il9 Ptpn11 Jak1 Mapk1 Tyk2 Stat5a Map2k2 Stat5b Map2k1 Akt1 Stat6 Jak3 Irs2 Pik3r1 Mapk3 Irs1 IL6%NETPATH%IL6 IL6 Gsk3b Erbb3 Ptk2 Erbb2 Hspb1 Map2k4 Crebbp Grb2 Ptk2b Jun Ptpn11 Bad Prkcd Hdac1 Hras Hsp90aa1 Il6ra Sirpa Eif2a Bmx Hnrnpa1 Il6 Pik3r2 Pik3r1 Cbl Eif4e Hnf1a Il6st Foxo1 Rb1 Vav1 Eif4ebp1 Map2k6 Tyk2 Lyn Cdk5 Nfkbia Gab2 Gab1 Foxo4 Map3k7 Pxn Sos1 Mapk8 Jak2 Rac1 Cebpb Jak1 Hck Daxx Fgr Ar Rps6ka2 Stat5a Stat5b Inppl1 Map3k4 Pias3 Plcg1 Shc1 Fes Inpp5d Ncoa1 Fyn Stat3 Stat1 Ep300 Mapk14 Fos Mapk1 Foxo3 Nlk Cdk9 Nfkb1 Tec Map2k2 Akt1 Map2k1 Btk Cd40 Socs3 Sgk1 Mapk3 IL5%NETPATH%IL5 IL5 Gsk3b Gsk3a Grb2 Ptk2b Jun Dnm2 Ptpn11 Ptpn6 Prkcd Il2rb Hcls1 Hras Alox5 Sox4 Il5 Ywhaz Rapgef1 Pik3r2 Cbl Pik3r1 Syk Pik3cg Vav1 Ctnnb1 Atf2 Prkcb Elk1 Lyn Nfkbia Pla2g4a Sos1 Jak2 Jak1 Sh2b2 Hck Csf2rb2 Stat5a Rps6ka1 Stat5b Bax Gnb2l1 Shc1 Raf1 Stat3 Sdcbp Stat1 Il5ra Mapk14 Shc2 Mapk1 Foxo3 Crkl Nfkb1 Map2k2 Unc119 Akt1 Btk Socs1 Mapk3 TSLP%NETPATH%TSLP TSLP Madd Dido1 Mdc1 Serbp1 Thoc5 Rpl7 Cic Plec Ptpn7 Tpd52l2 Fam63a Srsf11 Stmn1 Hsp90aa1 Nfkb2 Relb Atf2 Ppp1r12a Nfkbia Rpl4 Nav1 Chd8 Nelfa Mapk10 Optn Hemgn Casc5 Ctnnd1 Cad Add3 Cd84 Zzef1 Add1 Irf2bpl Mki67 Sp110 Brd4 Tjap1 Hck Atf7 Lmnb1 Csf2rb2 Ncapd2 Gpsm3 Phldb1 Ahctf1 Arhgap21 Cdca8 Numa1 Stat5a Crtc2 Chek1 Stat5b Tex2 Pdlim5 Fcer1g Inppl1 Dbnl Tmem41b Tagln3 Rpap1 Mtdh Icam2 Ube2o Pum1 Shank3 Pspc1 Tmem63a Fes Fam120a Ppp1r11 Tln1 Camsap1 Fyn Etv3 Stat3 Hcfc1 Stat1 Supt3 Atrx Crlf2 Pabpc1 Puf60 Rnf168 Akap13 Foxo3 Gatad2b Sept2 Sept1 Tslp Lmna Larp4b Map2k2 Kdm3b Rbm7 Btk Map2k1 Stat6 Sema4b Wiz Clasp2 Lcp1 Stk10 Tagln2 Ptpn18 Src Pik3ca Cdv3 Vasp Ptpn11 Ptpn6 Stat4 Eif4e Dock2 Rela Ncoa3 Eif4ebp1 Mapk12 Zc3hav1 Dock5 Srrm2 Lyn Rlim Bod1l Pank1 Med24 Wdr33 Gab2 Oxtr Ldlrap1 Nup153 Mapk8 Jak2 Itgb3 Jak1 Il7r Mtmr10 Shc1 Eprs Itsn2 Dapp1 Mapk14 Mapk1 Wipf1 Nfkb1 Tec Dok2 Mapk9 Mprip Junb Akt1 Yes1 Lck Skap2 Mapk3 BCR%NETPATH%BCR BCR Ptk2 Nedd9 Casp7 Mapkapk2 Chuk Rel Cbl Syk Ikbkb Ikbkg Atf2 Casp3 Nfkbia Rasa1 Malt1 Hck Bcl2l11 Ccne1 Casp9 Itpr1 Dbnl Bax Fyn Stat3 Stat1 Creb1 Foxo3 Crkl Card11 Map2k2 Map2k1 Btk Gsk3b Gsk3a Ptpn18 Grb2 Cd5 Ptk2b Ptprc Cblb Jun Dnm2 Vasp Pik3ap1 Ptpn11 Prkcd Ptpn6 Hcls1 Rapgef1 Pik3r2 Fosb Pik3r1 Crk Nfatc2 Foxo1 Vav2 Rb1 Pik3cd Cdk4 Rela Pik3cg Vav1 Ctnnb1 Prkce Csk Pip5k1b Ccnd3 Eif4ebp1 Prkcb Prkcq Gtf2i Lyn Elk1 Gab2 Cdk2 Gab1 Map3k7 Itk Sos1 Sos2 Mapk8 Dok1 Bcl2 Sh3bp2 Prkd1 Sh2b2 Pdpk1 Rasgrp3 Hnrnpk Cdk7 Cd22 Stap1 Pip4k2a Rps6ka1 Pip4k2b Dok3 Pip4k2c Bcar1 Bank1 Nfatc3 Hdac7 Bcl6 Ccl4 Lat2 Cdk6 Rras2 Was Plcg1 Ccna2 Hdac5 Plcg2 Lime1 Rap2a Mapk4 Ccnd2 Shc1 Itpr2 Inpp5d Pip5k1a Lcp2 Cd19 Raf1 Pip5k1c Dapp1 Fcgr2b Zap70 Mapk14 Blnk Tcl1 Chst15 Map4k1 Fos Cmtm3 Braf Cr2 Mapk1 Cd72 Cd79a Cd79b Btla Nfkb1 Atp2b4 Nck1 Cd81 Tec Blk Mapk9 Plekha2 Junb Bcl10 Plekha1 Akt1 Sla2 Lck Mapk3 GABA-B_RECEPTOR_II_SIGNALING%PANTHER PATHWAY%P05731 GABA-B_receptor_II_signaling Gnb1 Gng11 Gnb3 Gnb2 Adcy2 Adcy1 Prkar2b Prkar2a Kcnj3 Gnb4 Gnai1 Gnai3 Prkar1b Prkar1a Gnao1 Gngt2 Gng7 Prkacb Gng8 Prkaca Adcy8 Adcy6 Adcy7 Adcy4 Adcy5 Cacna1g Gng4 Cacna1a Cacna1b Gabbr2 Gng3 Adcy9 Gabbr1 DNA REPLICATION%PANTHER PATHWAY%P00017 DNA replication Pcna H3f3a H3f3b Pola1 Rfc5 Dna2 Rfc3 Top2b Top2a Rfc4 Rfc1 Rfc2 Rpa2 Prim1 Top1 Pold2 Pold1 Hist1h3h Rnaseh1 PRPP BIOSYNTHESIS%PANTHER PATHWAY%P02760 PRPP biosynthesis NICOTINE PHARMACODYNAMICS PATHWAY%PANTHER PATHWAY%P06587 Nicotine pharmacodynamics pathway Gnb1 Adcy2 Gnai1 Chrnb3 Chrnb2 Ddc Chrnb4 Ppp1r1b Gng2 Epb4.1 Slc18a2 Chrna5 Ppp1ca Chrna6 Chrna4 Cacna1c Th Kcnk9 Kcnk3 Epb4.1l2 Clic6 Chrna3 Flna Drd2 Drd4 Prkaca Cacna1g CYTOSKELETAL REGULATION BY RHO GTPASE%PANTHER PATHWAY%P00016 Cytoskeletal regulation by Rho GTPase Stmn4 Tubb1 Tubb6 Ssh1 Tubb3 Pfn1 Diap2 Myh11 Tubb5 Myh14 Pfn2 Diap1 Myh13 Mylk2 Myh10 Mylk3 Pfn3 Limk1 Actb Stmn1 Wasl Tubb4a Tubb4b Cfl2 Pak6 Pak7 Pak2 Pak3 Pak4 Mylk Actg1 Pak1 Vasp Arhgap8 Arhgap1 Acta2 Acta1 Rac2 Rac1 Myh3 Myh1 Arpc3 Myh2 Arpc2 Arhgef1 Myh7 Myh4 Myh9 Myh6 Arpc1a Myh8 Arpc1b Actbl2 Rock1 Tubb2b Tubb2a Rock2 Arpc5 Rhoc Rhou Arpc4 Actc1 Myo3b VITAMIN B6 BIOSYNTHESIS%PANTHER PATHWAY%P02786 Vitamin B6 biosynthesis HISTAMINE SYNTHESIS%PANTHER PATHWAY%P04387 Histamine synthesis Hdc ALLANTOIN DEGRADATION%PANTHER PATHWAY%P02725 Allantoin degradation Allc HETEROTRIMERIC G-PROTEIN SIGNALING PATHWAY-GI ALPHA AND GS ALPHA MEDIATED PATHWAY%PANTHER PATHWAY%P00026 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway Drd2 Drd4 Htr2a Drd1 Htr2c Htr2b Chrm2 Chrm3 Cltc Chrm1 Htr1a Htr1b Chrm4 Chrm5 Htr4 Gnrhr Adrbk2 Adrbk1 Oprk1 Gng2 Htr7 Drd5 Htr6 Grk5 Grk1 Grk6 Grk4 Kcnj9 Mtnr1a Kcnj6 Kcnj5 Htr1d Gngt1 Mtnr1b Htr1f Gys2 Cltb Gys1 Clta Adrb2 Gsk3b Adra2b Gsk3a Rap1b Gnal Adrb1 Adra2c Phkg1 Adrb3 Phkg2 Rap1a Adra1d Ep300 Adra1b Adra1a Pygm Pygl Creb3l4 Creb3l3 Adora1 Creb3l2 Creb3l1 Adcy3 Oprd1 Phka1 Phka2 Pygb Phkb Oprl1 Sstr3 Sstr2 Sstr5 Sstr4 Rgs8 Rgs9 Rgs6 Rgs7 Adora3 Gnai2 Oprm1 Crebbp Creb1 Creb3 Gng10 Sstr1 Rgs19 Rgs1 Rgs2 Rgs14 Hrh1 Rgs18 Gpr50 Rgs17 Hrh2 Rgs4 Rgs5 Hrh3 Rgs13 Hrh4 Rgs16 Rgs3 Gpsm1 Grm7 Grm8 Grm2 Adora2b Adora2a Gng12 Gpsm2 Rgs11 Rgs12 Htr5a Rgs10 Grm3 Grm4 Grm5 Grm1 Gnb1 Gnb2 Adcy2 Adcy1 Prkar2b Prkar2a Kcnj3 Gnai1 Gnai3 Prkar1b Prkar1a Gngt2 Gng7 Prkacb Gng8 Prkaca Adcy8 Adcy6 Adcy7 Adcy4 Adcy5 Gng4 Gng3 Adcy9 AMINOBUTYRATE DEGRADATION%PANTHER PATHWAY%P02726 Aminobutyrate degradation Abat MRNA SPLICING%PANTHER PATHWAY%P00058 mRNA splicing Snrpb2 Snrpa Snrnp40 Prpf3 Zrsr2 SCW_SIGNALING_PATHWAY%PANTHER PATHWAY%P06216 SCW_signaling_pathway CIRCADIAN CLOCK SYSTEM%PANTHER PATHWAY%P00015 Circadian clock system Csnk1d Arntl Cry1 Csnk1e Per1 Per2 Clock Cry2 Per3 P53 PATHWAY FEEDBACK LOOPS 2%PANTHER PATHWAY%P04398 p53 pathway feedback loops 2 Akt2 Akt3 Pik3cb Ppp2ca Pik3cd Pik3cg Ppp2cb Tpte Trp53 Pik3c3 Rb1 Akt1 Cdk2 Nras Pten Cdkn1a Rbl1 Pik3r2 Pik3r1 Pik3r3 Myc Pdpk1 Pik3r5 Trp73 Ccng1 Hras Mapk13 Ccna1 Pik3c2g Mapk14 Mapk12 Pik3c2a Pik3c2b Ccna2 Mapk11 Siah1a Ctnnb1 Pik3ca Atm Ccne1 Kras Trp63 5HT1 TYPE RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04373 5HT1 type receptor mediated signaling pathway Gnb1 Gng11 Gnb3 Gnb2 Adcy2 Prkar2b Prkar2a Gnb4 Gnai1 Gnai3 Htr1a Htr1b Gnai2 Gng2 Gng10 Gnao1 Gngt2 Kcnk9 Gng7 Kcnk3 Htr1d Htr1f Stx3 Prkacb Prkx Gng8 Vamp1 Prkaca Snap29 Vamp2 Slc6a4 Adcy7 Gng12 Vamp3 Gng4 Snap25 Gng3 Gnb5 Snap23 COENZYME A BIOSYNTHESIS%PANTHER PATHWAY%P02736 Coenzyme A biosynthesis Ppcs Pank1 Dcakd Pank3 Pank2 Pank4 5HT4 TYPE RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04376 5HT4 type receptor mediated signaling pathway Gnb1 Gnb3 Gnb2 Adcy2 Gnb4 Htr4 Slc18a1 Vamp8 Gng2 Gng10 Slc18a2 Gngt2 Kcnk9 Gng7 Kcnk3 Stx3 Gng8 Vamp1 Snap29 Vamp2 Adcy7 Gnal Slc6a4 Gng12 Vamp3 Gng4 Snap25 Gng3 Gnb5 Snap23 ANGIOGENESIS%PANTHER PATHWAY%P00005 Angiogenesis Prkce Prkcb Grb7 Prkcd Prkcg Akt2 Pdgfrb Prkch Akt3 Pik3cb Prkci Axin1 Pik3cd Prkca Pik3cg Pdgfra F3 Wnt7b Kdr Pik3c3 Dvl1 F7 Dok1 Akt1 Nck2 Nras Dok2 Dok3 Jak1 Angpt2 Pik3r2 Sfrp1 Pik3r1 Mapk8 Pik3r3 Grb14 Grap Angpt1 Fgfr1 Casp9 Hspb1 Dlk1 Hras Prkcz Sphk2 Wnt5a Mapk14 Wnt5b Src Prkd2 Pik3c2a Prkd1 Pik3c2b Ctnnb1 Pik3ca Notch1 Wnt7a Notch2 Crk Notch4 Prkcq Dvl2 Dvl3 Pld2 Tek Tcf7l2 Pld1 Map3k1 Araf Sphk1 Prkd3 Cryaa Prr5 Tgfb1i1 Cryab Ephb3 Ptprb Ephb2 Ephb1 Fzd1 Map2k4 Fzd3 Jag1 Fzd2 Jag2 Fzd5 Crkl Wnt2 Ptk2 Birc5 Ets1 Fos Raf1 Epha3 Pla2g4d Stat1 Stat3 Sh2d2a Rbpj Rbpjl Nos3 Fgf1 Wnt1 Jun Lpxn Shc2 Shc1 Sos1 Sos2 Plcg1 Plcg2 Mapkapk2 Mapkapk3 Dll3 Wnt2b Dll4 Mapk3 Mapk1 Dll1 Pdgfb Gsk3b Pdgfa Efnb1 Pxn Map2k1 Map2k2 Efnb2 F2r Braf Wnt10a Pdgfc Pdgfd Tcf7 Rasa1 Wnt10b Hif1a Pak2 Pak3 Pak1 Arhgap8 Arhgap1 Rhoc Rhoa Rhob Frzb Apc2 Pla2g4c Vegfa Frs3 Frs2 Pla2g4a Apc LEUCINE BIOSYNTHESIS%PANTHER PATHWAY%P02749 Leucine biosynthesis Bcat1 Bcat2 INTEGRIN SIGNALLING PATHWAY%PANTHER PATHWAY%P00034 Integrin signalling pathway Dock1 Elmo1 Elmo2 Col3a1 Rap2b Rap2a Ptpn12 Pik3cb Col2a1 Col8a2 Pik3cd Col8a1 Pik3cg Dnajc27 Col6a1 Itga10 Arf6 Pik3c3 Itga11 Flnb Col20a1 Itga2b Nras Ilk Col10a1 Itgbl1 Csk Lims2 Pik3r2 Vcl Pik3r1 Mapk8 Pik3r3 Col1a1 Mapk6 Rap2c Col1a2 Mapk9 Arl1 Hras Dmbt1 Mapk13 Arpc5l Rnd3 Rnd2 Arhgap10 Fyn Src Cav1 Pik3c2a Arf1 Pik3c2b Col4a4 Asap1 Arfgap1 Rras Itgav Pik3ca Itgax Tln1 Lamb3 Flna Lamb2 Rnd1 Col5a1 Col4a5 Rapgef1 Crk Col9a1 Col9a2 Col9a3 Col6a3 Col6a2 Col4a3 Col4a2 Col4a1 Ntn4 Col5a3 Col5a2 Araf Map2k3 Col4a6 Map2k4 Crkl Col15a1 Ptk2 Raf1 Map3k4 Lama1 Lama2 Col17a1 Shc1 Col14a1 Sos1 Actn4 Sos2 Map3k5 Lama3 Bcar1 Col11a2 Fn1 Col11a1 Actn1 Col13a1 Mapk3 Col12a1 Actn2 Itga8 Itga7 Itga6 Itga5 Pxn Ptk2b Rap1b Map2k1 Map2k2 Parvb Itga9 Col16a1 Itga2 Braf Map3k2 Map3k3 Rap1a Parva Lama5 Itga3 Itga4 Itga1 Actb Actg1 Vasp Rac2 Rac1 Arpc3 Arpc2 Arpc1a Arpc1b Actbl2 Itgad Lamc1 Itgb7 Itgb6 Itgb4 Arpc5 Itgb5 Rhoc Arhgap26 Lamc2 Col27a1 Itgal Mapk10 Lamb1 Lamc3 Itgb8 Itgae Itgam Rhoa Rhob Itgb1 Itgb2 CORTOCOTROPIN RELEASING FACTOR RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04380 Cortocotropin releasing factor receptor signaling pathway Gnb1 Gnb3 Gnb2 Gnb4 Crh Pomc Crhr1 Crhr2 Vamp8 Gng2 Gng10 Gngt2 Gng7 Gnaq Gna11 Gna14 Stx3 Gng8 Vamp1 Snap29 Vamp2 Gnal Gng12 Vamp3 Gng4 Snap25 Gng3 Gnb5 Snap23 GENERAL TRANSCRIPTION BY RNA POLYMERASE I%PANTHER PATHWAY%P00022 General transcription by RNA polymerase I Taf1a Taf1c Polr1d Ttf1 Taf1b Ptrf Taf8 Tbpl2 Tbp Psmc3ip Polr2k Rrn3 Tbpl1 Polr1b Ubtf TGF-BETA SIGNALING PATHWAY%PANTHER PATHWAY%P00052 TGF-beta signaling pathway Acvr1 Gdf5 Gdf6 Gdf7 Inhbb Inhba Inhbc Gdf2 Foxh1 Snip1 Gdf11 Gdf10 Gdf9 Gdf15 Amhr2 Zfyve16 Fkbp2 Gdnf Nras Bmpr1a Bmp10 Skil Lefty2 Bmpr1b Bmp15 Mapk8 Crebbp Smurf1 Mapk9 Smurf2 Dcp1b Hras Bmp8a Mapk13 Mapk14 Mapk12 Mapk11 Rras Mapk10 Acvr2b Zfyve9 Acvrl1 Acvr2a Fosl1 Smad4 Smad1 Bambi Smad3 Tgfb3 Junb Smad2 Smad7 Jun Smad6 Smad5 Fkbp1b Fkbp1a Bmpr2 Tgfb2 Lefty1 Smad9 Acvr1b Ski Nodal Jund Tgfbr2 Mapk3 Bmp7 Mapk1 Bmp5 Tgfbr1 Atf2 Bmp6 Map3k7 Bmp4 Bmp3 Bmp2 Bmp1 Cited2 Cited1 Mstn Tab1 Tll2 Acvr1c Ep300 Tll1 Inhbe Gdf3 UBIQUITIN PROTEASOME PATHWAY%PANTHER PATHWAY%P00060 Ubiquitin proteasome pathway Uba3 Uba2 Ube2a Ube2e1 Ube2e2 Uba1 Ube2e3 Smurf1 Ube2b Smurf2 Ube2c Atg7 Ube2l3 Ube2l6 Ube2k Psmd1 Psmd7 Ube2t Ube2n Mdm2 Ube2d1 Ube3a Psmd4 Psmd2 Ube3b Ube3c Sae1 Trex2 Ube2v2 Ube2d3 Psmd13 Psmd14 Wwp2 Uba7 Wwp1 Itch Ube2g1 Ube2g2 Psmc4 Uba6 SYNAPTIC_VESICLE_TRAFFICKING%PANTHER PATHWAY%P05734 Synaptic_vesicle_trafficking Stx1b Stx2 Stx1a Syt5 Vamp1 Syt3 Syt11 Syt12 Syt2 Syt7 Syt6 Stxbp1 Unc13d Nsf Unc13c Snap25 Unc13b Syt15 Rab3a Syt1 ASCORBATE DEGRADATION%PANTHER PATHWAY%P02729 Ascorbate degradation Rpe PHENYLETHYLAMINE DEGRADATION%PANTHER PATHWAY%P02766 Phenylethylamine degradation Aoc2 Aoc3 Aoc1 VASOPRESSIN SYNTHESIS%PANTHER PATHWAY%P04395 Vasopressin synthesis Cpe Oxt Sec11c Prep Avp Nhlrc3 Sec11a Pam Prepl Spcs2 Spcs3 MUSCARINIC ACETYLCHOLINE RECEPTOR 1 AND 3 SIGNALING PATHWAY%PANTHER PATHWAY%P00042 Muscarinic acetylcholine receptor 1 and 3 signaling pathway Prkce Prkcb Prkcd Prkcg Prkch Prkci Prkca Gng10 Prkcz Stx1b Stx1a Prkcq Gnb1 Gng11 Gnb3 Gnb2 Gnb4 Chrm3 Chrm1 Vamp8 Bche Slc18a3 Grin1 Slc5a7 Itpr3 Gngt2 Itpr2 Gng7 Itpr1 Gnaq Gna11 Gna14 Gng8 Grin2a Vamp1 Ache Snap29 Vamp2 Vamp3 Grin2d Pkn3 Gng4 Grin2c Grin2b Snap25 Pkn2 Pkn1 Gng3 Chat Gnb5 Snap23 Plcb4 CARNITINE METABOLISM%PANTHER PATHWAY%P02733 Carnitine metabolism Sugct METHYLCITRATE CYCLE%PANTHER PATHWAY%P02754 Methylcitrate cycle Aco1 Ireb2 TRIACYLGLYCEROL METABOLISM%PANTHER PATHWAY%P02782 Triacylglycerol metabolism Lipe Lipc SALVAGE PYRIMIDINE DEOXYRIBONUCLEOTIDES%PANTHER PATHWAY%P02774 Salvage pyrimidine deoxyribonucleotides Adat2 Tk1 Cda ANANDAMIDE_DEGRADATION%PANTHER PATHWAY%P05728 Anandamide_degradation Faah PENTOSE PHOSPHATE PATHWAY%PANTHER PATHWAY%P02762 Pentose phosphate pathway Hk1 Pgd Taldo1 Gpi1 Hkdc1 Rpia Tkt Hk2 GLYCOLYSIS%PANTHER PATHWAY%P00024 Glycolysis Hk1 Bpgm Pgk1 Eno2 Gpi1 Pklr Pkm Hkdc1 Pfkm Pfkl Hk2 Aldoa Eno1b Pgam2 Tpi1 Eno1 ADRENALINE AND NORADRENALINE BIOSYNTHESIS%PANTHER PATHWAY%P00001 Adrenaline and noradrenaline biosynthesis Nnmt Slc6a18 Slc6a2 Slc6a3 Vti1b Slc6a17 Slc6a19 Dbh Maoa Maob Slc6a15 Stx7 Slc18a1 Stx12 Ddc Comt Slc6a20a Pnmt Inmt Slc18a2 Th Vamp1 Snap29 Vamp2 Snap25 Snap23 PLASMINOGEN ACTIVATING CASCADE%PANTHER PATHWAY%P00050 Plasminogen activating cascade Mmp9 Mmp13 Plat Mmp1a Mmp3 Serpinb2 Plaur Plau Cpb2 Fgb Fgg Serpine1 Fga Plg Serpinf2 O-ANTIGEN BIOSYNTHESIS%PANTHER PATHWAY%P02757 O-antigen biosynthesis Gfpt1 Gfpt2 Tgds HEME BIOSYNTHESIS%PANTHER PATHWAY%P02746 Heme biosynthesis Rsad1 Alad Urod Hmbs Qars Ears2 Ppox Cox10 Cpox Fech Eprs ANDROGEN ESTROGENE PROGESTERONE BIOSYNTHESIS%PANTHER PATHWAY%P02727 Androgen estrogene progesterone biosynthesis Hsd17b7 Hsd17b1 Soat1 Hsd17b6 Hsd17b3 Lipa Cyp19a1 Hsd17b2 Soat2 HUNTINGTON DISEASE%PANTHER PATHWAY%P00029 Huntington disease Akt2 Akt3 Arf6 Trp53 Akt1 Mapk9 Trp73 Arl1 Arpc5l Optn Arf3 Map3k10 Arf4 Kalrn Arf1 Dync2h1 Dync1i1 Hap1 Dlg4 Cyfip2 Ap2a1 Ap2a2 Rhoq Rhoj Apaf1 Trp63 Cyfip1 Rhog Pacsin1 Casp3 Grik4 Grik5 Htt Bdnf Casp8 Capn10 Dnah8 Hip1r Map2k4 Rab8a Arfip2 Grik2 Grik3 Dnah5 Grik1 Dync1li2 Dctn1 Cyc1 Map2k7 Gapdhs Fos Dync1h1 Arf5 Dync1li1 Actr2 Dynll2 Dynll1 Taf4a Arl4c Sp1 Arl4a Dync1i2 Jun Grin1 Cltb Capn6 Capn1 Capn5 Grin2a Capn7 Dnaic2 Capn9 Ift57 Grin2d Hip1 Capn11 Grin2c Tnfaip8 Grin2b Capn2 Ep300 Dnal4 Synj1 Capn3 Tubb1 Tubb6 Tubb3 Tubb5 Crebbp Actb Wasl Tubb4a Tubb4b Actg1 Acta2 Acta1 Rac2 Rac1 Arpc1a Arpc1b Actbl2 Tubb2b Tubb2a Arpc5 Actc1 Tbp ARGININE BIOSYNTHESIS%PANTHER PATHWAY%P02728 Arginine biosynthesis Cad Nags Asl Ass1 Cps1 Otc NOTCH SIGNALING PATHWAY%PANTHER PATHWAY%P00045 Notch signaling pathway Jag1 Jag2 Ncstn Psen1 Fbxw7 Neurl2 Adam10 Neurl4 Pofut1 Lfng Mfng Fut8 Maml1 Rbpj Adam17 Rbpjl Neurl1a Numb Dlk1 Notch3 Lnx1 Cir1 Ncor2 Lnx2 Dll3 Dll4 Notch1 Notch2 Notch4 SUCCINATE TO PROPRIONATE CONVERSION%PANTHER PATHWAY%P02777 Succinate to proprionate conversion Mut Echdc1 Pccb BUPROPION_DEGRADATION%PANTHER PATHWAY%P05729 Bupropion_degradation Cyp2b10 PYRUVATE METABOLISM%PANTHER PATHWAY%P02772 Pyruvate metabolism Pklr Pkm Me1 Cs Pdha2 Pcx Pdha1 Acly Pck1 Clybl DE NOVO PYRIMIDINE DEOXYRIBONUCLEOTIDE BIOSYNTHESIS%PANTHER PATHWAY%P02739 De novo pyrimidine deoxyribonucleotide biosynthesis Adat2 Rrm1 Rrm2 Rrm2b Nme3 Tyms Nme4 Dut Dscaml1 Dtymk Nme1 AXON GUIDANCE MEDIATED BY SLIT ROBO%PANTHER PATHWAY%P00008 Axon guidance mediated by Slit Robo Ntng1 Tbc1d24 Slit3 Slit2 Robo1 Rhoc Srgap1 Abl1 Ntn1 Dcc Slit1 Cxcr4 Rac2 Rac1 Ntn4 Cxcl12 P53 PATHWAY%PANTHER PATHWAY%P00059 p53 pathway Mta2 Cdkn2a Pml Traf2 Akt2 Gtse1 Cdc25c Akt3 Hdac1 Sfn Ppp2ca Sumo3 Wrn Cdk1 Ppp2cb Kat2b Tpte Gadd45g Trp53 Gadd45a Gadd45b Sin3a Akt1 Cdk2 Pten Cdkn1a Mdm4 Chek2 Pdpk1 Crebbp Trp73 Mdm2 Pik3ca Atm Ccne1 Trp63 Sirt1 Ep300 5HT2 TYPE RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04374 5HT2 type receptor mediated signaling pathway Prkce Gnb1 Htr2a Prkcb Gng11 Gnb3 Htr2c Prkcd Gnb2 Htr2b Prkcg Prkch Prkci Prkca Gnb4 Plcb2 Slc18a1 Plcb1 Plcd4 Plcz1 Plcb3 Gng2 Plcd1 Gng10 Slc18a2 Plce1 Prkcz Gngt2 Plcg1 Kcnk9 Gng7 Plcg2 Kcnk3 Gnaq Gna11 Gna14 Gng8 Slc6a4 Prkcq Gng12 Gng4 Gng3 Gnb5 Plcb4 T CELL ACTIVATION%PANTHER PATHWAY%P00053 T cell activation Lcp2 Ikbkb Ptprc Cd247 Akt2 Lck Ppp3ca Akt3 Grap2 Pik3cb Was Cd80 Pik3cd Vav3 Pik3cg Nfkbia Cd86 Vav1 Zap70 Pik3c3 Lat Vav2 Akt1 Nck2 Nras Csk Pik3r2 Pik3r1 Mapk8 Cd3d Pik3r3 Chuk Ppp3cb Ppp3cc Mapk9 Cd3g Hras Cd3e Pak2 Pak3 Pik3ca Pak1 Rac1 Prkcq Map3k1 Araf Fos Raf1 Jun Sos1 Sos2 Plcg1 Itpr1 Mapk3 Mapk1 Map2k1 Map2k2 Braf PROLINE BIOSYNTHESIS%PANTHER PATHWAY%P02768 Proline biosynthesis MUSCARINIC ACETYLCHOLINE RECEPTOR 2 AND 4 SIGNALING PATHWAY%PANTHER PATHWAY%P00043 Muscarinic acetylcholine receptor 2 and 4 signaling pathway Adcy10 Stx16 Gnai2 Gng10 Stx1b Stx1a Gnb1 Gng11 Gnb3 Gnb2 Prkar2b Prkar2a Kcnj3 Gnb4 Gnai1 Gnai3 Chrm2 Chrm4 Vamp8 Bche Slc18a3 Prkar1b Prkar1a Kcnj9 Slc5a7 Gnao1 Kcnj6 Gngt2 Kcnj5 Gng7 Slc6a8 Stx4a Stx19 Stx11 Gnat1 Gnat2 Prkacb Prkx Gng8 Prkaca Vamp1 Ache Snap29 Vamp2 Vamp3 Gng4 Snap25 Gng3 Chat Gnb5 Snap23 FORMYLTETRAHYDROFORMATE BIOSYNTHESIS%PANTHER PATHWAY%P02743 Formyltetrahydroformate biosynthesis Dhfr Mtr Mthfd2 Mthfd1l Tyms GLUTAMINE GLUTAMATE CONVERSION%PANTHER PATHWAY%P02745 Glutamine glutamate conversion Glud1 Lgsn Glul METABOTROPIC GLUTAMATE RECEPTOR GROUP I PATHWAY%PANTHER PATHWAY%P00041 Metabotropic glutamate receptor group I pathway Prkcb Grin1 Prkar1b Grik5 Prkar1a Itpr1 Gnaq Gna11 Grik1 Prkacb Prkx Prkaca Grin2a Gna15 Grina Grin2d Grin2c Homer1 Grin2b Grm5 Plcb4 Grm1 METHIONINE BIOSYNTHESIS%PANTHER PATHWAY%P02753 Methionine biosynthesis Mtr ADENINE AND HYPOXANTHINE SALVAGE PATHWAY%PANTHER PATHWAY%P02723 Adenine and hypoxanthine salvage pathway Hprt Ada Aprt Pnp Xdh ANGIOTENSIN_II-STIMULATED_SIGNALING_THROUGH_G_PROTEINS_AND_BETA-ARRESTIN%PANTHER PATHWAY%P05911 Angiotensin_II-stimulated_signaling_through_G_proteins_and_beta-arrestin Gnb1 Arrb2 Agt Gng11 Elk1 Gnb3 Gnb2 Arrb1 Egr1 Agtr1a Prkca Gnb4 Raf1 Plcb2 Plcb1 Adrbk2 Adrbk1 Plcb3 Gng10 Grk5 Grk6 Itpr3 Gngt2 Itpr2 Gng7 Itpr1 Gnaq Mapk3 Mapk1 Gng8 Map2k1 Map2k2 Gng4 Gng3 Gnb5 5-HYDROXYTRYPTAMINE DEGREDATION%PANTHER PATHWAY%P04372 5-Hydroxytryptamine degredation Maoa Maob Aldh2 Aldh1a2 Aldh1a1 Aldh8a1 Aldh9a1 Aldh1a3 Aldh16a1 Il4i1 Aldh3a1 Aldh1b1 Aldh3a2 Aldh1l2 Aldh7a1 Aldh4a1 Aldh1l1 P53 PATHWAY BY GLUCOSE DEPRIVATION%PANTHER PATHWAY%P04397 p53 pathway by glucose deprivation Akt2 Akt3 Ppp2ca Prkag1 Ppp2cb Rps6kb2 Eif4ebp1 Trp53 Prkab2 Trp63 Prkab1 Akt1 Tsc2 Tsc1 Prkaa2 Prkaa1 Igbp1 Stk11 Trp73 ALZHEIMER DISEASE-AMYLOID SECRETASE PATHWAY%PANTHER PATHWAY%P00003 Alzheimer disease-amyloid secretase pathway Prkce Prkcb Prkcd Prkcg Prkch Prkci Prkca Ncstn Psen1 Adam10 Mapk8 Mapk6 Adam17 Mapk9 Mapk13 Prkcz Mapk14 Mapk12 Cacna1c Mapk11 Prkcq Cacna1s Furin Mapk10 Chrm2 Aph1b Chrm3 Pcsk1 Apba3 Chrm1 Apba1 Pcsk4 App Chrm4 Pcsk2 Chrm5 Pcsk6 Adam9 Cacna1d Cacna1f Mapk4 Mapk15 Apba2 Mapk7 Chrna7 Klc4 Klc3 Psen2 Kat5 Pcsk7 Bace1 Bace2 Cacnb2 Mapk3 Klc1 Mapk1 Klc2 Cacnb1 Pkn3 Pkn2 Pkn1 GENERAL TRANSCRIPTION REGULATION%PANTHER PATHWAY%P00023 General transcription regulation Taf1c Ttf1 Taf8 Taf7 Ak6 Taf2 Gtf2h3 Taf4a Gtf2h4 Taf6 Gtf2f1 Gtf2f2 Gtf2h1 Mterf2 Gtf2e1 Gtf2e2 Gtf2a1 Taf9b Brf2 Brf1 Cfap20 Gtf2b Taf11 Polr2f Taf12 Gtf2a2 Polr2c Taf9 Gtf2a1l Tbpl1 Polr2h VALINE BIOSYNTHESIS%PANTHER PATHWAY%P02785 Valine biosynthesis Ilvbl Bcat1 Bcat2 GBB_SIGNALING_PATHWAY%PANTHER PATHWAY%P06214 GBB_signaling_pathway COBALAMIN BIOSYNTHESIS%PANTHER PATHWAY%P02735 Cobalamin biosynthesis DPP-SCW_SIGNALING_PATHWAY%PANTHER PATHWAY%P06212 DPP-SCW_signaling_pathway GASTRIN_CCK2R_240212%PANTHER PATHWAY%P06959 Gastrin_CCK2R_240212 Prkce Rps6ka1 Prkcb Tpcn1 Klf4 Prkcd Rps6ka3 Traf6 Srf Prkch Tpcn2 Pik3cb Arhgef28 Ryr3 Csnk1a1 Prkca Ryr1 Ryr2 Snai1 Akt1s1 Prkg1 Jak2 Akt1 Pparg Gucy2e Ywhab Pten Grb2 Hbegf Csk Gast Irs1 Mapk8 Pik3r1 Ap2m1 Cdh1 Cck Pdpk1 Cd38 Elavl1 Mapk9 Eif4e Hspb1 Ptpn11 Odc1 Nr2c2 Map2k5 Clu Mapk14 Map2k6 Src Bcl2l1 Mmp3 Prkd2 Sp3 Prkd1 Nfatc2 Bcl2 Hdac7 Mef2d Pde1a Ctnnb1 Itgav Dnm1 Nos1 Map3k14 Ptgs2 Eif4ebp1 Map3k11 Tcf4 Men1 Bax Camkk1 Bad Crk Cnksr1 Akap1 Prkcq Ier3 Camk4 Foxo1 Plau Mef2b Tpst1 Mef2c Yes1 Lyn Araf Cckbr Arhgap4 Foxo3 Casp3 Map2k4 Ptk2 Fos Raf1 Stat3 Gng2 Sp1 Mapk7 Slc18a2 Jun Shc1 Sos1 Plcg1 Itpr1 Bcar1 Mapk3 Mapk1 Atf2 Gsk3b Pxn Ptk2b Map2k1 Map2k2 Braf Ppp3ca Nfkbia Cpe Creb1 Rgs2 Pak1 Rac1 Gnb1 Arrb2 Rock1 Elk1 Elk4 Egr1 Adcy1 Mapk10 Rhoa Itgb1 Pla2g4a Csnk1d Csnk1e Prkacb Prkaca PYRIDOXAL PHOSPHATE SALVAGE PATHWAY%PANTHER PATHWAY%P02770 Pyridoxal phosphate salvage pathway Pdxk Pnpo HETEROTRIMERIC G-PROTEIN SIGNALING PATHWAY-GQ ALPHA AND GO ALPHA MEDIATED PATHWAY%PANTHER PATHWAY%P00027 Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway Prkce Prkcb Prkcd Prkcg Prkch Prkci Prkca Dnajc27 Prkcz Drd2 Drd4 Prkcq Drd1 Chrm2 Rap1gap Chrm3 Cltc Bdkrb2 Chrm1 Bdkrb1 Cacna1e Gng13 Chrm4 Gpr45 Chrm5 Garnl3 Plcb2 Rasgrp4 Rasgrp3 Plcb1 Gnrhr Rasgrp2 Adrbk2 Rasgrp1 Adrbk1 Plcb3 Oprk1 Gng2 Drd5 Grk5 Grk6 Grk4 Kcnj9 Itpr3 Itpr2 Kcnj6 Kcnj5 Itpr1 Gngt1 Cltb Clta Rap1b Rap1a Plcb4 Adora1 Oprd1 Oprl1 Sstr3 Sstr2 Sstr5 Sstr4 Rgs8 Rgs9 Rgs6 Rgs7 Adora3 Oprm1 Gng10 Sstr1 Rgs19 Rgs1 Rgs2 Rgs14 Rgs18 Rgs17 Rgs4 Rgs5 Rgs13 Rgs16 Rgs3 Gpsm1 Grm7 Grm8 Grm2 Adora2b Adora2a Gng12 Arhgef1 Gpsm2 Rgs11 Rgs12 Rgs10 Grm3 Grm4 Grm5 Grm1 Gnb1 Gnb3 Gnb2 Kcnj3 Gnb4 Rhoa Gnao1 Gngt2 Gng7 Gnaq Gna11 Gna14 Gng8 Gna15 Gng4 Cacna1a Cacna1b Gng3 IONOTROPIC GLUTAMATE RECEPTOR PATHWAY%PANTHER PATHWAY%P00037 Ionotropic glutamate receptor pathway Grik4 Grik5 Slc1a3 Slc1a7 Grik2 Gria3 Grik3 Gria4 Slc1a2 Grik1 Vamp8 Grin1 Stx19 Stx11 Camk2d Camk2b Grin2a Vamp1 Grm2 Snap29 Vamp2 Gria1 Shank1 Camk2a Vamp3 Gria2 Grin2d Slc17a8 Cacng5 Grin2c Nsf Shank3 Grin2b Slc17a6 Pick1 Grm3 Snap25 Slc1a6 Cacng2 Slc1a1 Snap23 MANNOSE METABOLISM%PANTHER PATHWAY%P02752 Mannose metabolism Gmppa Gmds Mpi Pmm1 Gmppb Pmm2 INSULIN IGF PATHWAY-PROTEIN KINASE B SIGNALING CASCADE%PANTHER PATHWAY%P00033 Insulin IGF pathway-protein kinase B signaling cascade Foxo3 Mdm2 Insr Pik3ca Igf2 Tpte Igf1 Ins2 Insrr Tsc2 Inppl1 Tsc1 Irs2 Gsk3b Igf1r Pten Igf2r Gsk3a Irs4 Mdm4 Irs1 Foxo1 Pdpk1 JAK STAT SIGNALING PATHWAY%PANTHER PATHWAY%P00038 JAK STAT signaling pathway Stat6 Pias3 Mapk14 Ptprc Jak2 Jak1 Stat1 Socs1 Stat3 Jak3 Stat5b Stat5a Pias1 Pias2 Stat4 MYO_SIGNALING_PATHWAY%PANTHER PATHWAY%P06215 MYO_signaling_pathway TRYPTOPHAN BIOSYNTHESIS%PANTHER PATHWAY%P02783 Tryptophan biosynthesis XANTHINE AND GUANINE SALVAGE PATHWAY%PANTHER PATHWAY%P02788 Xanthine and guanine salvage pathway Hprt Gda Pnp ORNITHINE DEGRADATION%PANTHER PATHWAY%P02758 Ornithine degradation Azin2 Azin1 Odc1 FRUCTOSE GALACTOSE METABOLISM%PANTHER PATHWAY%P02744 Fructose galactose metabolism Hk1 Hkdc1 Aldoa Khk Galt Aldob Gale Hk2 Aldoc P38 MAPK PATHWAY%PANTHER PATHWAY%P05918 p38 MAPK pathway Elk1 Traf6 Srf Map2k4 Gadd45a Il1r1 Dusp1 Rps6ka4 Dusp10 Tab2 Rps6ka5 Eif4e Mknk2 Hspb1 Eef2k Mapk13 Mknk1 Map3k4 Mapk14 Map2k6 Map3k10 Mapk12 Map3k5 Mapk11 Mef2d Mapkapk2 Mapkapk3 Map3k7 Mef2b Tab1 Mef2c LYSINE BIOSYNTHESIS%PANTHER PATHWAY%P02751 Lysine biosynthesis HISTIDINE BIOSYNTHESIS%PANTHER PATHWAY%P02747 Histidine biosynthesis WNT SIGNALING PATHWAY%PANTHER PATHWAY%P00057 Wnt signaling pathway Ppp2ca Ppp2cb Siah1a Ctnnb1 Gng2 Itpr3 Itpr2 Itpr1 Plcb4 Crebbp Gng10 Gng12 Fat1 Gnb1 Cdh22 Cdh20 Gnb3 Fat3 Gnb2 Cdh23 Pcdh8 Cdh24 Fat2 Tbl1x Ppp3r1 Ppp3r2 Siah2 Pcdh11x Pcdha12 Gnb4 Pcdha11 Tcf7l1 Frzb Cdh7 Cdh8 Lef1 Cdh9 Csnk2b Pcdh20 Aes Csnk1d Wnt16 Gng7 Hdac2 Csnk1e Hdac3 Cdh3 Cdh2 Hdac8 Cdh4 Cdh6 Cdh5 Ankrd6 Sfrp2 Gng8 Sfrp4 Srcap Btrc Sfrp5 Csnk2a2 Dchs1 Pcdh7 Pcdh9 Gng4 Ino80 Pcdh1 Tbl1xr1 Wnt3a Gng3 Pcdhac2 Pcdhac1 Pcdhgc5 Prkce Pcdhb15 Prkcb Pcdhb13 Pcdhb10 Prkcd Fzd6 Prkcg Fzd7 Fzd4 Prkch Pcdhb19 Prkci Pcdhb18 Axin1 Pcdhb17 Csnk1a1 Prkca Pcdhb16 Fzd8 Fzd9 Wnt7b Bcl9 Nfatc4 Dvl1 Pcdhgb7 Fbxw11 Bmpr1a Cer1 Ctbp2 Ctbp1 Tle1 Sfrp1 Bmpr1b Tle2 Tle3 Cdh1 Tle4 Chd1l Tle6 Kremen2 Hltf Pcdhgc3 Kremen1 Prkcz Pygo2 Wnt5a Pcdhga3 Pcdhga1 Wnt5b Pcdhga2 Pcdhga6 Nfatc2 Pcdhga7 Pygo1 Pcdhga5 Pcdha9 Pcdha6 Pcdhga8 Pcdha8 Pcdhga12 Pcdha5 Pcdha7 Pcdha4 Nfatc3 Pcdhgb4 Wnt7a Nfatc1 Pcdhgb6 Nkd2 Pcdhb20 Prkcq Nkd1 Dvl2 Pcdhgb2 Dvl3 Celsr2 Celsr3 Pcdhb22 Tcf7l2 Pcdhb21 Smarcd1 Smarcd3 Smarcd2 Celsr1 Pcdhb5 Pcdhb1 Pcdhb2 Wnt8b Cdhr1 Pcdhb3 Hdac1 Ctnnal1 Cdhr2 Fzd1 Csnk1g2 Nlk Fzd3 Smarca5 Arr3 Fzd2 Wnt8a Smarcb1 Fzd5 Csnk1g3 Fzd10 Wnt2 Pcdha1 Pcdha3 Wnt9b Ctnna3 Pcdhga10 Gng13 Pcdhgb1 Pcdhga11 Pcdha2 Smad4 Plcb2 Lrp5 Smad1 Plcb1 Smarcc1 Smarcal1 Smarcc2 Plcb3 Ctnna1 Ctnna2 Lrp6 Wnt1 Wnt9a Cdh19 Ppp2r5c Smad5 Cdh16 Wnt11 Cdh17 Wnt3 Arid1a Wnt4 Pcdh19 Acvr1b Pcdh10 Pcdh15 Pcdh18 Wnt2b Ppp2r5a Ppp2r5b Pcdh12 Ppp2r5d Tgfbr1 Smarce1 Gsk3b Hells Ppp2r5e Map3k7 Dact1 Sag Smarca4 Smarca2 Smarca1 Ep400 Wnt10a Cdh15 Cdh12 Cdh13 Cdh10 Acvr1c Ep300 Cdh11 Wnt10b Wnt6 Fstl1 Ppp3ca Ppp3cb Ppp3cc Arrb2 Arrb1 Gnaq Gna11 Gna14 Gna15 DE NOVO PURINE BIOSYNTHESIS%PANTHER PATHWAY%P02738 De novo purine biosynthesis Nme6 Nme7 Rrm2b Nme3 Nme4 Dscaml1 Nme1 Ak1 Rrm1 Nme5 Rrm2 Ak2 Ak3 Ak5 Ppat Guk1 Gart Ak8 Adsl Adss Adssl1 Atic Gmps ATP SYNTHESIS%PANTHER PATHWAY%P02721 ATP synthesis Atp5c1 Atp5b PNAT%PANTHER PATHWAY%P05912 PNAT Slc6a3 Dbh Maoa Maob Gnai2 Comt Ppp1ca Th Kcnk9 Kcnk3 Epb4.1l2 Clic6 Flna Drd2 Drd4 Gnb1 Gng11 Drd1 Gnb3 Gnb2 Ppp1cc Adcy2 Gnaz Prkar2b Epb4.1l3 Prkar2a Gnb4 Gnai1 Gnai3 Vamp8 Ddc Ppp1r1b Drd5 Epb4.1 Slc18a2 Prkacb Stx3 Prkx Gng8 Prkaca Vamp1 Snap29 Vamp2 Adcy7 Vamp3 Gng4 Snap25 Gng3 Snap23 PYRIMIDINE METABOLISM%PANTHER PATHWAY%P02771 Pyrimidine Metabolism Cda Dpyd Nt5e Aldh6a1 Upb1 Dpysl3 Abat Dpysl2 Dpysl5 Dpys CADHERIN SIGNALING PATHWAY%PANTHER PATHWAY%P00012 Cadherin signaling pathway Pcdhgc5 Pcdhb15 Pcdhb13 Pcdhb10 Fzd6 Fzd7 Fzd4 Pcdhb19 Pcdhb18 Pcdhb17 Pcdhb16 Fzd8 Wnt7b Fzd9 Pcdhgb7 Cdh1 Pcdhgc3 Wnt5a Pcdhga3 Wnt5b Pcdhga1 Fyn Src Pcdhga2 Pcdhga6 Pcdhga7 Pcdhga5 Pcdha9 Ctnnb1 Pcdha6 Pcdhga8 Pcdha8 Pcdhga12 Pcdha5 Pcdha7 Pcdha4 Wnt7a Pcdhgb4 Pcdhgb6 Pcdhb20 Pcdhgb2 Celsr2 Celsr3 Tcf7l2 Pcdhb22 Pcdhb21 Yes1 Lyn Celsr1 Pcdhb5 Pcdhb1 Pcdhb2 Wnt8b Cdhr1 Pcdhb3 Cdhr2 Fzd1 Fzd3 Fzd2 Wnt8a Fzd5 Fzd10 Wnt2 Pcdha1 Pcdha3 Wnt9b Pcdhga10 Pcdhgb1 Pcdhga11 Pcdha2 Actr2 Wnt1 Wnt9a Cdh19 Cdh16 Wnt11 Cdh17 Wnt3 Wnt4 Pcdh19 Pcdh10 Pcdh15 Pcdh18 Wnt2b Pcdh12 Gsk3b Cdh15 Wnt10a Cdh12 Cdh13 Cdh10 Cdh11 Wnt6 Wnt10b Fstl1 Actb Ptpn1 Egfr Fer Erbb3 Erbb2 Actg1 Ctnnd1 Ctnnd2 Acta2 Frk Erbb4 Acta1 Actbl2 Fat1 Cdh22 Cdh20 Fat3 Cdh23 Pcdh8 Cdh24 Fat2 Pcdh11x Pcdha12 Pcdha11 Actc1 Tcf7l1 Cdh7 Cdh8 Lef1 Cdh9 Csnk2b Pcdh20 Wnt16 Cdh3 Cdh2 Cdh4 Cdh6 Cdh5 Csnk2a2 Dchs1 Pcdh7 Pcdh9 Pcdh1 Wnt3a Pcdhac2 Pcdhac1 APOPTOSIS SIGNALING PATHWAY%PANTHER PATHWAY%P00006 Apoptosis signaling pathway Prkce Prkcb Prkcd Akt2 Prkcg Akt3 Prkch Pik3cb Prkca Pik3cd Pik3cg Trp53 Akt1 Mapk8 Mapk9 Casp9 Hspa1l Diablo Daxx Bcl2l1 Eif2ak2 Hspa1a Rel Bcl2 Fas Xiap Nfkb1 Nfkb2 Pik3ca Bok Tnfrsf10b Map3k14 Birc2 Birc3 Tnfrsf1b Apaf1 Tnfrsf1a Bag3 Prkra Bax Bag4 Cradd Cflar Prkcq Bik Map4k4 Map4k3 Bcl2l10 Bcl2l11 Bcl2l2 Endog Map3k1 Atf7 Fadd Atf3 Map2k3 Atf4 Aifm1 Hspa2 Casp3 Tmbim6 Hspa8 Traf2 Hspa5 Eif2s1 Map4k2 Casp8 Atf6 Madd Bak1 Map2k4 Casp7 Ltb Lta Atf6b Tnfsf10 Jdp2 Gzmb Mcl1 Fasl Gzmf Map2k7 Ripk1 Fos Tnf Relb Rela Tradd Jun Map3k5 Mapk3 Mapk1 Atf2 Ikbkb Nfkbia Igf2r Chuk Mapk10 INTERFERON-GAMMA SIGNALING PATHWAY%PANTHER PATHWAY%P00035 Interferon-gamma signaling pathway Socs2 Socs5 Socs4 Mapk10 Ifng Socs3 Ifngr1 Socs7 Socs6 Jak2 Cish Pias4 Ifngr2 Ptpn6 Jak1 Mapk8 Stat1 Mapk15 Mapk9 Mapk13 Pias3 Mapk14 Mapk12 Mapk11 Mapk3 Mapk1 Pias1 Pias2 RAS PATHWAY%PANTHER PATHWAY%P04393 Ras Pathway Rps6ka1 Rps6ka3 Srf Akt3 Pik3cb Pik3cd Pik3cg Pik3c3 Akt1 Nras Grb2 Mapk8 Pdpk1 Mapk9 Hras Mapk13 Map2k6 Mapk14 Mapk12 Pak2 Pak3 Mapk11 Pik3ca Pak1 Kras Rac2 Rac1 Pld2 Pld1 Map3k1 Araf Map2k3 Elk1 Rhoc Map2k4 Mapk10 Rhoa Rhob Map2k7 Ets1 Raf1 Stat1 Stat3 Jun Rps6ka2 Map3k4 Tiam1 Shc1 Sos1 Exoc2 Sos2 Ralb Rala Rps6ka6 Ralgds Mapkapk2 Mapkapk3 Rac3 Rgl2 Rgl1 Mapk3 Mapk1 Atf2 Gsk3b Gsk3a Map2k1 Map2k2 Braf CHORISMATE BIOSYNTHESIS%PANTHER PATHWAY%P02734 Chorismate biosynthesis P53 PATHWAY FEEDBACK LOOPS 1%PANTHER PATHWAY%P04392 P53 pathway feedback loops 1 Mdm4 Mdm2 Trp73 Trp53 Trp63 OXYTOCIN RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04391 Oxytocin receptor mediated signaling pathway Prkce Gnb1 Prkcb Gnb3 Prkcd Gnb2 Prkcg Prkch Prkci Prkca Gnb4 Plcb2 Plcb1 Vamp8 Plcd4 Plcz1 Plcb3 Plcd1 Gng2 Gng10 Prkcz Plce1 Gngt2 Plcg1 Gng7 Plcg2 Gnaq Gna11 Gna14 Oxtr Stx3 Gng8 Vamp1 Snap29 Vamp2 Prkcq Gng12 Vamp3 Gng4 Snap25 Gng3 Gnb5 Snap23 Plcb4 ACETATE UTILIZATION%PANTHER PATHWAY%P02722 Acetate utilization Acss2 Acss1 OXIDATIVE STRESS RESPONSE%PANTHER PATHWAY%P00046 Oxidative stress response Elk1 Dusp27 Map2k4 Dupd1 Dusp26 Ddit3 Max Dusp3 Dusp22 Dusp1 Dusp10 Mapk8 Stat1 Myc Mknk2 Mapk9 Pla2g4a Eef2k Mapk13 Mknk1 Jun Mapk14 Map2k6 Mapk12 Bcl2 Mapk11 Dusp9 Dusp8 Dusp19 Dusp6 Dusp4 Dusp7 Dusp2 Dusp5 Dusp12 Mef2c Txn1 Dusp16 Dusp14 Dusp18 Map2k3 Dusp15 ALZHEIMER DISEASE-PRESENILIN PATHWAY%PANTHER PATHWAY%P00004 Alzheimer disease-presenilin pathway Fzd6 Fzd7 Fzd4 Fzd8 Wnt7b Fzd9 Dvl1 Ncstn Psen1 Cdh1 Adam17 Notch3 Mmp9 Wnt5a Mmp13 Wnt5b Mmp1a Ctnnb1 Notch1 Wnt7a Notch2 Notch4 Dvl2 Dvl3 Tcf7l2 Mmp25 Lrp1 Mmp23 Mmp24 Wnt8b Mmp20 Furin Sra1 Mmp27 Mmp21 Trim3 Fzd1 Apbb2 Lrp1b Fzd3 Trim2 Wnt8a Fzd2 Kat7 Fzd5 Fzd10 Aph1b Wnt2 Mmp7 Mmp2 Pcsk1 Cd44 Wnt9b Trpc4 Mmp19 Pcsk4 App Mllt4 Pcsk2 Pvrl1 Pcsk6 Mmp8 Lrp5 Mmp17 Actr2 Mmp14 Jup Ern1 Rbpj Lrp4 Rbpjl Lrp2 Lrp6 Mmp16 Wnt9a Mmp15 Wnt1 Psen2 Wnt11 Wnt3 Wnt4 Kat5 Pcsk7 Bace1 Bace2 Wnt2b Trpc5 Trpc6 Trpc7 Trpc1 Gsk3b Wnt10a Wnt6 Wnt10b Fstl1 Actb Actg1 Acta2 Acta1 Erbb4 Actbl2 Actc1 Tcf7l1 Lef1 Wnt16 Cdh3 Wnt3a BETA3 ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04379 Beta3 adrenergic receptor signaling pathway Gnb1 Gnb3 Gnb2 Adcy2 Gnb4 Vamp8 Gng2 Gng10 Gngt2 Gng7 Stx3 Gng8 Vamp1 Snap29 Vamp2 Adcy7 Gnal Gng12 Vamp3 Adrb3 Gng4 Snap25 Gng3 Gnb5 Snap23 PANTOTHENATE BIOSYNTHESIS%PANTHER PATHWAY%P02761 Pantothenate biosynthesis ALANINE BIOSYNTHESIS%PANTHER PATHWAY%P02724 Alanine biosynthesis Bcat1 Bcat2 OPIOID PROOPIOMELANOCORTIN PATHWAY%PANTHER PATHWAY%P05917 Opioid proopiomelanocortin pathway Gnb1 Gnb3 Gnb2 Adcy2 Oprd1 Gnb4 Gnai1 Gnai3 Pomc Gnai2 Vamp8 Gng2 Gng10 Gnao1 Gngt2 Gng7 Stx3 Gng8 Vamp1 Snap29 Vamp2 Adcy7 Gng12 Vamp3 Gng4 Snap25 Gng3 Gnb5 Snap23 TOLL RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00054 Toll receptor signaling pathway Tlr7 Tlr6 Ikbkb Tlr8 Elk1 Irak3 Ube2v1 Traf6 Tlr9 Tollip Irak4 Cd14 Ikbke Tlr2 Nfkbia Ly96 Tlr3 Nfkbie Tlr4 Myd88 Ticam2 Mapk8 Tank Chuk Tnfaip3 Map3k8 Irf3 Irak1 Mapk9 Tbk1 Tirap Ecsit Jun Mapk14 Ube2n Mapk3 Map3k7 Map2k1 Map2k2 Tab1 Map2k3 VITAMIN B6 METABOLISM%PANTHER PATHWAY%P02787 Vitamin B6 metabolism Psat1 Pdxk Pnpo HETEROTRIMERIC G-PROTEIN SIGNALING PATHWAY-ROD OUTER SEGMENT PHOTOTRANSDUCTION%PANTHER PATHWAY%P00028 Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction Gnb1 Gnb2 Gnb4 Gng13 Rgs9 Gng2 Gng10 Pdc Cngb3 Grk1 Pde6g Rho Cnga3 Pde6b Gngt2 Pde6a Gng7 Calml3 Gngt1 Gnat1 Prkacb Gng8 Prkaca Gng12 Gng4 Rcvrn Cnga1 Gng3 Gnb5 UNTITLED%PANTHER PATHWAY%P06664 untitled Tgif1 Skil Rela HEDGEHOG SIGNALING PATHWAY%PANTHER PATHWAY%P00025 Hedgehog signaling pathway Prkar1b Prkar1a Stk36 Smo Csnk1a1 Csnk1e Prkar2b Prkar2a Shh Ubr5 Gsk3b Fbxw11 Btrc Gli1 Sufu Ptch1 Gli3 Crebbp PHENYLPROPIONATE DEGRADATION%PANTHER PATHWAY%P02767 Phenylpropionate degradation BETA2 ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04378 Beta2 adrenergic receptor signaling pathway Gnb1 Gnb3 Gnb2 Gngt2 Gng7 Adcy2 Prkar2b Prkar2a Gnb4 Prkacb Adrb2 Prkx Gng8 Prkaca Adcy7 Gnal Gng12 Gng4 Gng3 Gng2 Gng10 Gnb5 PURINE METABOLISM%PANTHER PATHWAY%P02769 Purine metabolism Nt5e Gda Ampd3 Xdh BMP_SIGNALING_PATHWAY-DROSOPHILA%PANTHER PATHWAY%P06211 BMP_signaling_pathway-drosophila OPIOID PROENKEPHALIN PATHWAY%PANTHER PATHWAY%P05915 Opioid proenkephalin pathway Gnb1 Gnb3 Gnb2 Adcy2 Oprd1 Gnb4 Gnai1 Gnai3 Pdyn Penk Gnai2 Vamp8 Gng2 Gng10 Gngt2 Gng7 Stx3 Gng8 Vamp1 Snap29 Vamp2 Adcy7 Gng12 Vamp3 Gng4 Snap25 Gng3 Gnb5 Snap23 SALVAGE PYRIMIDINE RIBONUCLEOTIDES%PANTHER PATHWAY%P02775 Salvage pyrimidine ribonucleotides Adat2 Uckl1 Uck2 Upp1 Nme3 Upp2 Uprt Nme4 Uck1 ALP23B_SIGNALING_PATHWAY%PANTHER PATHWAY%P06209 ALP23B_signaling_pathway METABOTROPIC GLUTAMATE RECEPTOR GROUP II PATHWAY%PANTHER PATHWAY%P00040 Metabotropic glutamate receptor group II pathway Gnb1 Gng11 Gnb3 Gnb2 Prkar2b Prkar2a Gnb4 Gnai1 Gnai3 Cacna1e Adcy10 Vamp8 Gnai2 Gng10 Prkar1b Prkar1a Gnao1 Gngt2 Gng7 Stx1b Cacnb1 Gnat2 Stx1a Prkacb Prkx Gng8 Vamp1 Prkaca Grm2 Snap29 Vamp2 Vamp3 Gng4 Cacna1a Cacna1b Grm3 Snap25 Gng3 Gnb5 Snap23 LIPOATE_BIOSYNTHESIS%PANTHER PATHWAY%P02750 Lipoate_biosynthesis Lias CELL CYCLE%PANTHER PATHWAY%P00013 Cell cycle Cinp Rpa3 Psmd11 Psmd12 Psmd3 Psmd7 Psme3 Ccne2 Ccnd3 Psmd4 Ccne1 Psmd13 Psmd14 Ccnd2 UNTITLED%PANTHER PATHWAY%P00019 untitled Prkce Ece1 Ece2 Prkcb Prkg2 Gucy1b3 Prkcd Akt2 Prkcg Akt3 Prkch Prkci Adcy3 Prkca Prkg1 Akt1 Adcy10 Sec11a Prkcz Sec11c Ptgs2 Prkcq Araf Furin Adcy2 Adcy1 Prkar2b Prkar2a Pcsk1 Raf1 Plcb2 Plcb1 Plcb3 Nos3 Pla2g4a Prkar1b Prkar1a Itpr3 Itpr2 Itpr1 Gnaq Gna11 Gna14 Mapk3 Mapk1 Prkacb Prkaca Adcy8 Map2k1 Adcy6 Gnal Map2k2 Adcy7 Adcy4 Adcy5 Gucy1a3 Gucy1a2 Edn1 Edn2 Ednra Ednrb Adcy9 Edn3 Plcb4 Ecel1 TYROSINE BIOSYNTHESIS%PANTHER PATHWAY%P02784 Tyrosine biosynthesis VITAMIN D METABOLISM AND PATHWAY%PANTHER PATHWAY%P04396 Vitamin D metabolism and pathway Rxra Cyp27a1 Gc F13b Rara Cyp27b1 Vdr FGF SIGNALING PATHWAY%PANTHER PATHWAY%P00021 FGF signaling pathway Prkce Prkcb Prkcd Prkcg Akt2 Prkch Akt3 Pik3cb Prkci Ppp2ca Pik3cd Prkca Pik3cg Ppp2cb Pik3c3 Akt1 Ywhab Nras Ptpn6 Mapk8 Grap Fgfr1 Mapk9 Hras Prkcz Mapk13 Map2k6 Mapk14 Mapk12 Pik3c2a Pik3c2b Mapk11 Pik3ca Prkcq Araf Map2k3 Fgfr3 Ywhag Fgfr2 Fgfr4 Fgf18 Ywhaz Fgf14 Map3k6 Sfn Fgf11 Fgf17 Map2k4 Fgf13 Fgf10 Ppp2r2d Fgf12 Ppp2r2c Ppp2r2b Fgf22 Fgf20 Map2k7 Raf1 Fgf1 Map3k4 Ppp2r5c Shc1 Sos1 Sos2 Map3k5 Plcg1 Plcg2 Ppp2r5a Spry3 Mapk3 Ppp2r5b Spry1 Spry4 Mapk1 Ppp2r5d Fgf8 Fgf7 Ppp2r5e Spry2 Fgf9 Map2k1 Fgf3 Map2k2 Fgf4 Fgf6 Fgf5 Rasa4 Map3k2 Ywhae Map3k3 Pebp1 Rasa2 Ppp2r1b Ppp2r2a Rasa1 Shc3 Ppp2r1a Rac2 Rac1 Mapk10 Frs3 Frs2 TOLL_PATHWAY_DROSOPHILA%PANTHER PATHWAY%P06217 Toll_pathway_drosophila HISTAMINE H1 RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04385 Histamine H1 receptor mediated signaling pathway Prkce Gnb1 Prkcb Gnb3 Prkcd Gnb2 Prkcg Prkch Prkci Prkca Gnb4 Plcb2 Plcb1 Plcd4 Plcz1 Plcb3 Plcd1 Gng2 Gng10 Prkcz Plce1 Hrh1 Itpr3 Gngt2 Itpr2 Plcg1 Gng7 Itpr1 Plcg2 Gnaq Gna11 Gna14 Gng8 Prkcq Gng12 Gng4 Gng3 Gnb5 Plcb4 METHYLMALONYL PATHWAY%PANTHER PATHWAY%P02755 Methylmalonyl pathway Mut Pccb Mcee Pcca 5-ARACHIDONYLGLYCEROL_BIOSYNTHESIS%PANTHER PATHWAY%P05726 5-arachidonylglycerol_biosynthesis Pla1a Liph Lpl Dagla Plcb2 Plcb1 Plcb3 COENZYME A LINKED CARNITINE METABOLISM%PANTHER PATHWAY%P02732 Coenzyme A linked carnitine metabolism Sugct CHOLESTEROL BIOSYNTHESIS%PANTHER PATHWAY%P00014 Cholesterol biosynthesis Pmvk Mvd Fdps Ggps1 Pdss1 Fdft1 Sqle Mvk Hmgcr Lss NICOTINIC ACETYLCHOLINE RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00044 Nicotinic acetylcholine receptor signaling pathway Myh11 Myh14 Stx16 Myh13 Myh10 Actb Chrna5 Myo5a Plekhh3 Actr1b Chrna6 Chrna4 Actr1a Myo1g Myo1f Chrnb1 Myo1a Stx1b Chrne Myo10 Actg1 Chrng Myo15 Chrnd Chrna3 Slc44a3 Acta2 Chrna10 Acta1 Myo9a Stx1a Myh3 Myh1 Myo16 Myh2 Myo5c Myo5b Myh7 Myh4 Myh9 Myh6 Myh8 Actbl2 Actc1 Myo3b Chrna2 Chrna1 Myo18a Myo18b Myo1c Myo1b Myo1e Myo1d Chrnb3 Vamp8 Chrnb2 Myo6 Chrnb4 Myo7b Myh15 Chrna9 Myo7a Chrna7 Bche Slc18a3 Slc5a7 Slc6a8 Stx4a Stx19 Stx11 Vamp1 Snap29 Ache Vamp2 Vamp3 Snap25 Chat Snap23 THIAMIN BIOSYNTHESIS%PANTHER PATHWAY%P02779 Thiamin biosynthesis N-ACETYLGLUCOSAMINE METABOLISM%PANTHER PATHWAY%P02756 N-acetylglucosamine metabolism Npl Gnpda1 Gnpda2 Gfpt1 Gfpt2 Amdhd2 GAMMA-AMINOBUTYRIC ACID SYNTHESIS%PANTHER PATHWAY%P04384 Gamma-aminobutyric acid synthesis Csad Abat Gad2 Aldh5a1 Gad1 BETA1 ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04377 Beta1 adrenergic receptor signaling pathway Gnb1 Gnb3 Gnb2 Adcy2 Prkar2b Prkar2a Gnb4 Vamp8 Gng2 Gng10 Gngt2 Gng7 Stx3 Prkacb Prkx Gng8 Prkaca Vamp1 Snap29 Vamp2 Adcy7 Gnal Gng12 Adrb1 Vamp3 Gng4 Snap25 Gng3 Gnb5 Snap23 SULFATE ASSIMILATION%PANTHER PATHWAY%P02778 Sulfate assimilation ENDOGENOUS_CANNABINOID_SIGNALING%PANTHER PATHWAY%P05730 Endogenous_cannabinoid_signaling Gnb1 Gng11 Gnb3 Gnb2 Gnao1 Gngt2 Cnr1 Gng7 Gnb4 Gnai1 Gnai3 Gng8 Plcb2 Cacna1g Plcb1 Gng4 Cacna1a Cacna1b Plcb3 Gng3 Grm5 Grm1 ACTIVINBETASIGNALING_PATHWAY%PANTHER PATHWAY%P06210 Activinbetasignaling_pathway BIOTIN BIOSYNTHESIS%PANTHER PATHWAY%P02731 Biotin biosynthesis SERINE GLYCINE BIOSYNTHESIS%PANTHER PATHWAY%P02776 Serine glycine biosynthesis Psph Psat1 Phgdh ALPHA ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00002 Alpha adrenergic receptor signaling pathway Prkce Prkcd Prkcg Itpr1 Prkca Gna11 Adra2a Stx6 Vamp1 Adra2b Vamp2 Adra2c Vamp3 Plcb2 Plcb1 Snap25 Plcb3 Adra1b Adra1a Plcb4 Snap23 Plce1 ISOLEUCINE BIOSYNTHESIS%PANTHER PATHWAY%P02748 Isoleucine biosynthesis Ilvbl Bcat1 Bcat2 INFLAMMATION MEDIATED BY CHEMOKINE AND CYTOKINE SIGNALING PATHWAY%PANTHER PATHWAY%P00031 Inflammation mediated by chemokine and cytokine signaling pathway Prkce Prkcb Akt2 Akt3 Pik3cb Socs5 Pik3cd Socs4 Pik3cg Ifng Col6a1 Socs7 Socs6 Nfatc4 Jak2 Col20a1 Akt1 Nras Pten Grap Pdpk1 Prkcz Arpc5l Nfatc2 Nfkb2 Rras Pik3ca Ptgs2 Kras Nfatc3 Rhog Nfatc1 Col6a3 Col6a2 Araf Raf1 Relb Rela Plcb2 Stat3 Plcb1 Plcd4 Plcz1 Plcb3 Gng2 Junb Plcd1 Plce1 Jun Grk6 Shc1 Col14a1 Sos1 Itpr3 Itpr2 Plcg1 Itpr1 Plcg2 Jund Mapk3 Col12a1 Mapk1 Cxcr4 Camk2d Prkx Ptk2b Camk2a Plcb4 Ikbkb Vav1 Inppl1 Myh11 Myh14 Myh13 Mylk2 Gnai2 Myh10 Chuk Mylk3 Actb Gng10 Ccl20 Alox5ap Ccl22 Cx3cl1 Cxcr5 C5ar1 Ifnar1 Cx3cr1 Pak6 Ltb4r2 Pak7 Ccl2 Cxcr6 Pak2 Ccl3 Pak3 Nfat5 Pak4 Il2 Mylk Ccl4 Actg1 Rgs4 Ccl5 Ccl7 Pak1 Cask Alox12 Rgs13 Ptgs1 Ccl12 Acta2 Alox15 Acta1 Ccl11 Rac2 Ccr10 Rac1 Xcr1 Myh3 Prex1 Myh1 Arpc3 Cxcr1 Ccr9 Myh2 Arpc2 Cxcr2 Gng12 Ccr8 Cxcr3 Myh7 Ccr7 Myh4 Ccr6 Ccrl2 Myh9 Cxcl10 Vwf Myh6 Arpc1a Ccr4 Ccr1 Ccr5 Fpr1 Myh8 Arpc1b Ccr2 Fpr3 Ccr3 Pf4 Actbl2 Rock1 Itgb7 Gnb3 Arpc5 Rhoc Arpc4 Adcy2 Itgal Gnai1 Actc1 Myo3b Gnai3 Rhoa Itgb1 Pla2g4a Gnao1 Gng7 Gnaq Gna11 Gna14 Prkacb Gng8 Prkaca Adcy6 Gna15 Adcy5 Gng4 Gng3 PYRIDOXAL-5-PHOSPHATE BIOSYNTHESIS%PANTHER PATHWAY%P02759 Pyridoxal-5-phosphate biosynthesis Psat1 Pnpo PEPTIDOGLYCAN BIOSYNTHESIS%PANTHER PATHWAY%P02763 Peptidoglycan biosynthesis INSULIN IGF PATHWAY-MITOGEN ACTIVATED PROTEIN KINASE KINASE MAP KINASE CASCADE%PANTHER PATHWAY%P00032 Insulin IGF pathway-mitogen activated protein kinase kinase MAP kinase cascade Rps6ka1 Elk1 Rps6ka3 Irs2 Igf1r Rps6ka4 Igf2r Fos Raf1 Rps6ka5 Irs4 Irs1 Rps6ka2 Sos1 Sos2 Rps6ka6 Insr Igf2 Rps6kb2 Igf1 Mapk3 Ins2 Mapk1 Insrr Map2k1 Map2k2 Rasa1 Map2k3 PDGF SIGNALING PATHWAY%PANTHER PATHWAY%P00047 PDGF signaling pathway Rps6ka1 Rps6ka3 Akt2 Pdgfrb Srf Pik3cb Pik3cd Prkca Pik3cg Pdgfra Pik3c3 Jak2 Nck2 Nras Grb2 Jak1 Pik3r2 Mapk8 Pik3r1 Pik3r3 Myc Grap Mapk6 Pdpk1 Pik3r5 Hras Arhgap10 Pik3ca Rps6kb2 Araf Arhgap4 Ets1 Fos Raf1 Stat1 Stat3 Mapk15 Mapk7 Map3k4 Jun Shc2 Shc1 Sos1 Srgap1 Itpr3 Sos2 Itpr2 Plcg1 Itpr1 Plcg2 Mapkapk2 Mapk3 Mapk1 Pdgfb Gsk3b Pdgfa Gsk3a Map2k1 Map2k2 Braf Rasa4 Map3k2 Rasa2 Pkn2 Rasa1 Shc3 Ikbkb Grap2 Erf Vav3 Erg Usf2 Vav1 Ehf Gab1 Gab2 Vav2 Chuk Stat6 Arhgap8 Arhgap1 Jak3 Stat5b Stat5a Stat4 Elk1 Elk4 Arhgap26 Mapk10 Rps6ka4 Rps6ka5 Mknk2 Mknk1 Fli1 Rps6ka2 Arhgap9 Arhgap42 Arhgap5 Stat2 Spdef Srgap3 Rps6ka6 Rab11b Arhgap6 Rerg Rps6kc1 Ninl Etv3 Arhgap12 Arhgap15 Mycbp Pdgfrl Fev Ophn1 Elf3 Elf4 Elf1 Elf2 Ikbkap Nin Elf5 Gabpa TETRAHYDROFOLATE BIOSYNTHESIS%PANTHER PATHWAY%P02742 Tetrahydrofolate biosynthesis Dhfr Fpgs Gch1 Tyms DE NOVO PYRIMIDINE RIBONUCLEOTIDES BIOSYTHESIS%PANTHER PATHWAY%P02740 De novo pyrimidine ribonucleotides biosythesis Ctps2 Ctps Dhodh Cad Nme3 Cps1 Nme4 Dscaml1 Nme1 5HT3 TYPE RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04375 5HT3 type receptor mediated signaling pathway Kcnk9 Kcnk3 Stx3 Vamp1 Snap29 Vamp2 Slc6a4 Vamp3 Slc18a1 Vamp8 Snap25 Snap23 Slc18a2 HYPOXIA RESPONSE VIA HIF ACTIVATION%PANTHER PATHWAY%P00030 Hypoxia response via HIF activation Akt2 Akt3 Arnt Vhl Egln2 Egln3 Tpte Akt1 Pten Mtor Txn2 Rorc Crebbp Txn1 Hif1a FLAVIN BIOSYNTHESIS%PANTHER PATHWAY%P02741 Flavin biosynthesis Rfk Flad1 THYROTROPIN-RELEASING HORMONE RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04394 Thyrotropin-releasing hormone receptor signaling pathway Prkce Prkcb Prkcd Prkcg Prkch Prkci Prkca Gng10 Prkcz Prkcq Gng12 Gnb1 Gnb3 Gnb2 Tshb Gnb4 Cacna1e Plcb2 Cga Plcb1 Trhr Vamp8 Trh Plcd4 Plcz1 Cacnb4 Plcb3 Cacnb3 Plcd1 Gng2 Plce1 Gngt2 Plcg1 Gng7 Plcg2 Gnaq Gna11 Gna14 Cacnb2 Cacnb1 Stx3 Gng8 Vamp1 Snap29 Vamp2 Vamp3 Gng4 Cacna1a Cacna1b Snap25 Gng3 Gnb5 Snap23 Plcb4 UNTITLED%PANTHER PATHWAY%P05916 untitled Gnb1 Gnb3 Gnb2 Adcy2 Gnb4 Gnai1 Gnai3 Pdyn Oxt Gnai2 Avp Vamp8 Oprk1 Gng2 Gng10 Gnao1 Gngt2 Gng7 Stx3 Gng8 Vamp1 Snap29 Vamp2 Adcy7 Gng12 Vamp3 Gng4 Snap25 Gng3 Gnb5 Snap23 THIAMINE METABOLISM%PANTHER PATHWAY%P02780 Thiamine metabolism Thtpa Tpk1 VEGF SIGNALING PATHWAY%PANTHER PATHWAY%P00056 VEGF signaling pathway Prkce Prkcb Prkcd Prkcg Prkch Pik3cb Prkci Pik3cd Prkca Pik3cg Kdr Pik3c3 Akt1 Nras Pik3r2 Pik3r1 Pik3r3 Casp9 Hspb1 Hras Prkcz Sphk2 Mapk14 Prkd2 Pik3c2a Prkd1 Pik3c2b Pik3ca Arhgap8 Arhgap1 Rac2 Rac1 Prkcq Araf Sphk1 Prkd3 Cryaa Prr5 Tgfb1i1 Cryab Ptk2 Ets1 Raf1 Sh2d2a Vegfa Nos3 Pla2g4a Lpxn Shc2 Plcg1 Plcg2 Mapkapk2 Mapkapk3 Rac3 Mapk3 Mapk1 Pxn Map2k1 Map2k2 Braf Hif1a TRANSCRIPTION REGULATION BY BZIP TRANSCRIPTION FACTOR%PANTHER PATHWAY%P00055 Transcription regulation by bZIP transcription factor Creb3l4 Creb3l3 Creb3l2 Creb3l1 Prkar2b Taf1c Prkar2a Ttf1 Taf8 Taf7 Ak6 Taf2 Gtf2h3 Taf4a Gtf2h4 Crebbp Taf6 Gtf2f1 Gtf2f2 Gtf2h1 Mterf2 Gtf2e1 Gtf2e2 Prkar1b Gtf2a1 Prkar1a Taf9b Brf2 Brf1 Cfap20 Gtf2b Taf11 Polr2f Taf12 Gtf2a2 Polr2c Taf9 Gtf2a1l Tbpl2 Polr2e Tbp Ttf2 Psmc3ip Tbpl1 Polr2h Ep300 ENKEPHALIN RELEASE%PANTHER PATHWAY%P05913 Enkephalin release Gnb1 Gnb3 Gnb2 Adcy2 Oprd1 Prkar2b Prkar2a Gnb4 Gnai1 Gnai3 Pdyn Penk Gnai2 Oprm1 Creb1 Gng2 Gng10 Gnao1 Gngt2 Gng7 Prkacb Prkx Gng8 Prkaca Adcy7 Gnal Gng12 Gng4 Gng3 Gnb5 AXON GUIDANCE MEDIATED BY SEMAPHORINS%PANTHER PATHWAY%P00007 Axon guidance mediated by semaphorins Fyn Crmp1 Plxnb1 Nrp1 Pak1 Frk Rhoa Rac2 Rac1 Arhgef1 Sema3a Dpysl2 Cdk5 Dpysl5 Plxna1 Dpys Sema4d Fes Dpysl4 PI3 KINASE PATHWAY%PANTHER PATHWAY%P00048 PI3 kinase pathway Gnb1 Foxo3 Gnb3 Gnb2 Akt2 Ywhaz Akt3 Pik3cb Gnb4 Gnai1 Gnai3 Jak2 Akt1 Inppl1 Nras Pten Irs1 Pik3r2 Pik3r1 Pik3r3 Gnai2 Pdpk1 Pik3r5 Casp9 Nos3 Sos1 Sos2 Gngt2 Foxo4 Gnaq Ptger1 Gngt1 Gna11 Insr Gna14 Pik3ca Inpp5a Rps6kb2 Gnat2 Gsk3b Foxo1 Gnb5 DPP_SIGNALING_PATHWAY%PANTHER PATHWAY%P06213 DPP_signaling_pathway B CELL ACTIVATION%PANTHER PATHWAY%P00010 B cell activation Prkcb Ikbkb Ptprc Prkcd Cd79b Cd79a Ppp3ca Pik3cb Pik3cd Vav3 Nfkbia Pik3cg Vav1 Vav2 Nras Grb2 Ptpn6 Mapk8 Chuk Ppp3cb Mapk9 Hras Mapk13 Mapk14 Mapk12 Mapk11 Pik3ca Rac2 Rac1 Araf Lyn Mapk10 Fos Raf1 Jun Sos1 Sos2 Itpr3 Itpr2 Plcg2 Itpr1 Mapk3 Mapk1 Map2k1 Map2k2 Cd19 Map3k2 Syk Map3k3 Cd22 Blnk Nfkbil1 Btk NICOTINE_DEGRADATION%PANTHER PATHWAY%P05914 Nicotine_degradation Cyp2a5 Ugt1a5 Fmo3 Ugt1a2 Inmt ASPARAGINE AND ASPARTATE BIOSYNTHESIS%PANTHER PATHWAY%P02730 Asparagine and aspartate biosynthesis Asns PARKINSON DISEASE%PANTHER PATHWAY%P00049 Parkinson disease Slc6a3 Lck Csnk1a1 Stx7 Fbxw11 Ywhab Fbxw7 Csk Mapk8 Stx12 Mapk9 Hspa1l Snca Psma2 Sncb Mapk14 Src Fyn Psma1 Mapk12 Hspa1a Psmb7 Ywhah Th Ube2j2 Gpr37l1 Ndufv2 Hspa9 Psmb3 Psmb1 Cask Ccne1 Psma7 Frk Gpr37 Pld2 Yes1 Lyn Psma4 Ywhag Hspa2 Psma3 Elk1 Psma6 Hspa8 Sncg Hspa5 Psma5 Ywhaz Tor2a Hck Sfn Fgr Csnk1g2 Park2 Sept5 Sept4 Mapk10 Sept2 Sept1 Tor1a Sncaip Csnk1g3 Cul1 Psmb10 Uchl1 Blk Adrbk2 Adrbk1 Mapk15 Mapk7 Ube2l3 Ube2l6 Csnk2b Ccne2 Csnk1d Csnk1e Mapk3 Mapk1 Csnk2a2 Ywhae CYSTEINE BIOSYNTHESIS%PANTHER PATHWAY%P02737 Cysteine biosynthesis Cbs METABOTROPIC GLUTAMATE RECEPTOR GROUP III PATHWAY%PANTHER PATHWAY%P00039 Metabotropic glutamate receptor group III pathway Slc1a3 Slc1a7 Gria3 Gria4 Slc1a2 Adcy10 Gnai2 Gng10 Stx1b Stx1a Vti1a Grm7 Grm8 Grm4 Grm5 Grm1 Gnb1 Gnb3 Grik4 Gnb2 Grik5 Prkar2b Prkar2a Grik2 Gnb4 Grik3 Gnai1 Gnai3 Grik1 Cacna1e Vamp8 Grin1 Prkar1b Prkar1a Gngt2 Gng7 Cacnb1 Prkacb Prkx Gng8 Grin2a Prkaca Vamp1 Snap29 Gria1 Vamp2 Vamp3 Gria2 Grin2d Gng4 Grin2c Cacna1a Grin2b Cacna1b Snap25 Slc1a6 Gng3 Gnb5 Slc1a1 Snap23 PHENYLALANINE BIOSYNTHESIS%PANTHER PATHWAY%P02765 Phenylalanine biosynthesis HISTAMINE H2 RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04386 Histamine H2 receptor mediated signaling pathway Gnb1 Gnb3 Gnb2 Gngt2 Gng7 Adcy2 Hrh2 Prkar2b Prkar2a Gnb4 Prkacb Prkx Gng8 Prkaca Adcy7 Gnal Gng12 Gng4 Gng3 Gng2 Gng10 Gnb5 AXON GUIDANCE MEDIATED BY NETRIN%PANTHER PATHWAY%P00009 Axon guidance mediated by netrin Rhou Pik3cb Pik3cd Pik3cg Nfatc4 Pik3r2 Pik3r1 Pik3r3 Pik3r5 Ntng1 Tbc1d24 Pik3c2a Nfatc2 Pik3c2b Plcg1 Plcg2 Ntn1 Pik3ca Vasp Dcc Nfatc3 Rac2 Rac1 Unc5c Unc5d Ablim1 Ntn4 Unc5b S-ADENOSYLMETHIONINE BIOSYNTHESIS%PANTHER PATHWAY%P02773 S-adenosylmethionine biosynthesis Mtr Mat1a Mat2a FAS SIGNALING PATHWAY%PANTHER PATHWAY%P00020 FAS signaling pathway Casp3 Casp8 Map2k4 Mapk10 Casp7 Fasl Cyc1 Mapk8 Casp6 Scin Gsn Lmnb1 Lmnb2 Casp9 Mapk9 Dffb Lmna Capg Jun Daxx Parp2 Parp1 Faf1 Fas Parp4 Map3k5 Parp3 Apaf1 Cflar Fadd TCA CYCLE%PANTHER PATHWAY%P00051 TCA cycle Ogdh Suclg1 Mdh1 Cs Sdhc Pdha2 Aco2 Pdk2 Pdha1 Fh1 THREONINE BIOSYNTHESIS%PANTHER PATHWAY%P02781 Threonine biosynthesis Thnsl1 INTERLEUKIN SIGNALING PATHWAY%PANTHER PATHWAY%P00036 Interleukin signaling pathway Rps6ka1 Ikbkb Rps6ka3 Akt2 Srf Akt3 Pik3cb Akt1 Irs2 Nras Cdkn1a Irs1 Chuk Mapk6 Myc Pdpk1 Spic Stat6 Cdkn1b Elk3 Il18 Il12rb1 Il12rb2 Il11ra2 Il2 Il4ra Gm13305 Il7 Il4 Pik3ca Il9 Il11 Il10 Il15 Il13 Il17f Il21 Il6st Il15ra Il17a Cxcr1 Il23a Il10rb Cxcr2 Il10ra Il2rb Mtor Il2ra Jak3 Il5ra Stat5b Il3ra Spi1 Stat5a Il1a Araf Il20ra Il6ra Stat4 Foxo3 Elk1 Elk4 Fos Raf1 Il13ra1 Stat1 Sla2 Stat3 Il6 Il5 Mapk15 Mknk2 Nos3 Mapk7 Il13ra2 Mknk1 Rps6ka2 Shc1 Sos1 Stat2 Sos2 Rps6ka6 Mapkapk2 Mapk3 Mapk1 Gsk3b Braf Rasa1 EGF RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00018 EGF receptor signaling pathway Prkce Prkcb Prkcd Prkcg Akt2 Prkch Akt3 Pik3cb Prkci Ppp2ca Pik3cd Prkca Pik3cg Ppp2cb Pik3c3 Akt1 Nras Cblc Ywhab Cblb Hbegf Dab2ip Egf Mras Mapk8 Gab3 Grap Pik3r5 Mapk9 Hras Mapk13 Prkcz Map2k6 Mapk14 Mapk12 Prkd2 Pik3c2a Prkd1 Pik3c2b Mapk11 Rras Pik3ca Prkcq Araf Map2k3 Prkd3 Ywhag Ywhaz Sfn Map2k4 Map2k7 Raf1 Stat1 Stat3 Map3k4 Ppp2r5c Shc2 Phldb2 Pebp4 Shc1 Sos1 Areg Sos2 Cbl Map3k5 Nrg2 Plcg1 Plcg2 Rras2 Nrg3 Nrg1 Ereg Nrg4 Spry3 Tgfa Ppp2r5a Spry1 Mapk3 Btc Ppp2r5b Spry4 Mapk1 Rasal2 Nf1 Ppp2r5d Ppp2r5e Spry2 Map2k1 Map2k2 Braf Rasa4 Map3k2 Ywhae Map3k3 Pebp1 Rasa2 Rasa1 Shc3 Gab1 Gab2 Stat6 Egfr Ywhah Erbb3 Erbb2 Erbb4 Rac2 Rac1 Stat5b Stat5a Stat4 Mapk10 Stat2 5-HYDROXYTRYPTAMINE BIOSYNTHESIS%PANTHER PATHWAY%P04371 5-Hydroxytryptamine biosynthesis Ddc Tph2 Tph1 BLOOD COAGULATION%PANTHER PATHWAY%P00011 Blood coagulation Klkb1 F2rl3 Gp1ba Thbd Pros1 F3 F13b F7 Serpina10 Itga2b F9 Gp9 Proc Gp5 F2 App Procr Tfpi F8 F12 Serpinc1 Kng2 F10 Proz Serpina1a Gp1bb Serpina1d Plat Serpinb2 Plaur F2r Plau Fgb Fgg Vwf Serpine1 Fga Plg Serpinf2 GSD 0 (MUSCLE)%REACTOME DATABASE ID RELEASE 59%3828062 GSD 0 (muscle) Gys1 Gyg PD-1 SIGNALING%REACTOME DATABASE ID RELEASE 59%389948 PD-1 signaling H2-Aa Cd3d Cd3e H2-Eb1 Lck Pdcd1lg2 Csk Cd4 Cd274 Ptpn6 Pdcd1 Ptpn11 Cd3g CHONDROITIN SULFATE BIOSYNTHESIS%REACTOME%R-HSA-2022870.1 Chondroitin sulfate biosynthesis Chst3 Chsy1 Chpf Bgn Dcn Chsy3 Bcan Chst15 Cspg4 Cspg5 Chst13 Csgalnact1 Csgalnact2 Ncan Chst12 Vcan Chst7 Chst11 ANCHORING OF THE BASAL BODY TO THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 59%5620912 Anchoring of the basal body to the plasma membrane Pafah1b1 Mks1 Rpgrip1l Nphp1 Ccp110 Nek2 Cep57 Cc2d2a Akap9 Haus7 Nphp4 Haus8 Ppp2r1a Ywhag Ywhae Cep97 Rab3ip Hsp90aa1 Ninl Ywhaq Cep152 Rab8a B9d2 Prkar2b Haus3 Haus4 Cdk1 Cep162 Cetn2 B9d1 Ofd1 Haus2 Ahi1 Cep63 Alms1 Haus5 Haus6 Haus1 Tubb4a Tubb4b Iqcb1 Rab11a Clasp1 Tmem67 Ssna1 Tubg1 Csnk1d Cep250 Tuba4a Dynll1 Csnk1e Cep135 Kif24 Cdk5rap2 Mapre1 Pcnt Sfi1 Cep70 Nedd1 Actr1a Cep131 Fbf1 Pcm1 Prkaca Dync1i2 Fgfr1op Cep76 Cep78 Cep72 Sept2 Dctn2 C2cd3 Sclt1 Dctn3 Ckap5 Cep164 Tubb5 Tuba1a Ttbk2 Cep41 Plk1 Mark4 Cenpj Cep83 Dync1h1 Cep89 Tctn3 Plk4 Sdccag8 Tctn1 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION%REACTOME DATABASE ID RELEASE 59%948021 Transport to the Golgi and subsequent modification Chst8 Trappc2 Tgfa Trappc3 Ins2 Mgat5 Mcfd2 Trappc1 Rab1 F5 Preb Copa F8 Sec24a Sec24b Sptan1 Sec13 Chst10 Tmed3 Mgat4a Mgat4b Sec24d Scfd1 Gria1 Sec24c Man2a1 Fut8 Arcn1 Tfg St6gal1 Ykt6 Cd59b Mgat4c Cog6 Lman2l Cog3 Cog4 Cog2 St8sia3 Sec31a Cog1 Ctage5 Gorasp1 Nsf St8sia2 Trappc6a St8sia6 Trappc6b Tmed9 Man1c1 Bet1l Gbf1 Ankrd28 St3gal4 Man1a Trappc9 Mgat3 Napb Napg Mgat2 Mgat1 Napa Trappc5 Spta1 Trappc4 Sptbn4 Dctn5 Dctn6 Ctsz Dctn1 Serpina1d Col7a1 Lman1l Dctn4 Areg Serpina1a Dync1li2 Folr1 Dync1li1 Man1a2 Rab1b Ppp6r1 Ppp6r3 Arf5 Cnih1 Kdelr2 Kdelr3 Uso1 Bet1 Stx17 Cnih3 Ctsc Cnih2 Cog7 Tmem115 Cog8 Fuca1 Arfgap3 Arfgap1 Arfgap2 Sar1b Golgb1 Copb2 Stx5a Manea Copb1 Ppp6c Copz1 Ank1 Ank3 Sec23a Copz2 Cga Lhb Trappc10 Sec23ip Copg1 Gosr1 Golga2 Dynll2 Gosr2 Arf1 Kdelr1 Arf3 Arf4 Dync1i1 Sptbn2 Trappc2l Sptbn1 Csnk1d Dynll1 B4galt3 Tbc1d20 B4galt1 Cope B4galt5 B4galt4 B4galt6 B4galt2 Sec16b Sec22a Lman1 Dync1i2 Sec22b Sptb Lman2 Sec16a Sec22c Dctn2 Dctn3 Dync1h1 INTERLEUKIN-10 SIGNALING%REACTOME%R-HSA-6783783.1 Interleukin-10 signaling Ccl5 Ccl4 Tnf Jak1 Fpr1 Timp1 Il12b Ccr1 Il12a Il10 Ccl3 Il13 Cd80 Il1rn Ptafr Tyk2 Stat3 Il10ra Icam1 Cxcl3 Cxcl1 Ptgs2 Il1r2 Ccl22 Il1r1 Ccl20 Ccr2 Ccr5 Il1b Cxcl10 Il1a Il18 Il10rb Il4 Il6 Csf3 Csf2 Ccl12 Tnfrsf1a Csf1 Fcer2a Tnfrsf1b Lif Cd86 SIGNALING BY PDGF%REACTOME DATABASE ID RELEASE 59%186797 Signaling by PDGF Akap9 Ppp2r1a Csf2 Cd86 Jak1 Cd80 Stat3 Adcy7 Adcy6 Adcy5 Adcy4 Adcy3 Adcy2 Prkar2a Adcy1 Frs2 Nras Frs3 Rasgrf1 Adcy9 Psmf1 Adcy8 Raf1 Psme4 Il5ra Fgf1 Bad Il17rd Fgf2 Cnksr1 Csk Cnksr2 Erbb2 Fgf9 Ptk2 Fgf7 Psme3 Fgf6 Fgf4 Fgf3 Furin Ppp5c Prkar1a Prkar1b Ranbp9 Ppp2cb Shc1 Lamtor2 Chuk Nrg2 Ppp2ca Shc3 Nrg1 Akt2 Akt3 Shc2 Psma7 Artn Nrtn Plcg1 Brap Nck2 Psmb5 Psmb4 Ubc Nrg3 Psmb7 Nrg4 Psmb6 Psmb2 Psmb3 Psmb1 Nck1 Mapk3 Akt1 Mapk1 Ksr1 Ptpra Dusp16 Dusp10 Map3k11 Pip4k2b Pip4k2a Trp53 Pip4k2c Paqr3 Pik3ap1 Pde1c Pde1b Psme2 Pde1a Psme1 Ncam1 Sos1 Rictor Braf Psmb10 Apbb1ip Col6a1 Col6a2 Ahcyl1 Col6a3 Col6a6 Rapgef1 Psmb11 Csf2rb2 Rapgef2 Csf2ra Mov10 Grb7 Casp9 Prkcd Prkce Actn2 Nf1 Prkcg Tsc2 Pdgfrb Stat5b Pdgfra Stat5a Plg Mlst8 Kbtbd7 Prkca Vav1 Il2rg Arrb2 Egfr Gab1 Arrb1 Mtor Ret Phlpp1 Adrbk1 Vwf Phlpp2 Ins2 Sptan1 Pspn Col4a5 Map2k1 Rbx1 Crkl Fgg Cdkn1a Map2k2 Cul3 Psmd12 Pdgfb Psmd11 Col9a1 Rasgef1a Col9a2 Col9a3 Psmd14 Rasa3 Rasa4 Psmd13 Psmd10 Il2 Rasa2 Rasa1 Nefl Spred3 Kit Spred2 Pdgfd Grin2a Spta1 Spred1 Il5 Sptbn4 Ppp2r1b Ywhab Ago2 Ago1 Ptpn12 Tnrc6c Kras Insr Gsk3a Gsk3b Tnrc6b Gdnf Shfm1 Tnrc6a Ago4 Ago3 Itpr1 Trat1 Irs2 Mdm2 Lck Syngap1 Pten Hbegf Irs1 Il3ra Btc Il2ra Il2rb Itpr3 Ptpn11 Angpt1 Itpr2 Trib3 Psmc6 Egf Fgf23 Psmc5 Fgf22 Mark3 Psmc2 Fgf20 Psmd2 Dab2ip Prkacb Tek Psmb9 Psmb8 Araf Hras Grin1 Prkar2b Ppp2r5e Mapkap1 Dlg4 Ppp2r5c Rps6kb2 Ppp2r5d Ppp2r5a Psmc1 Psmc4 Psmc3 Pik3cb Foxo3 Sptbn2 Pik3cd Foxo1 Sptbn1 Itgb3 Fyn Creb1 Phb Spp1 Grin2c Stat1 Rasgrp4 Rasgrp3 Stat6 Pebp1 Camk4 Ppp2r5b Rasgrp1 Ier3 Tln1 Pik3ca Col4a3 Col4a2 Thbs4 Col4a4 Col4a1 Cdkn1b Fga Fgb Grin2d Thbs1 Prkaca Grin2b Nr4a1 Sptb Prr5 Thbs3 Hgf Thbs2 Gfra2 Gfra3 Pip5k1a Gfra4 Ereg Jak2 Pea15a Itga2b Rap1a Jak3 Wdr83 Camk2d Rap1b Camk2a Fgfr4 Camk2b Psma5 Rasal3 Plat Rasal2 Psma4 Psma3 Psma6 Akt1s1 Vcl Camk2g Psma2 Psma1 Gfra1 Pip5k1b Cd19 Pip5k1c Psmd9 Dusp7 Iqgap1 Fgf16 Dusp6 Dusp9 Fgf15 Dusp8 Klb Fgf18 Them4 Psmd1 Met Fn1 Bcar1 Rasal1 Dusp1 Psmd3 Psmd4 Pdpk1 Psmd6 Psmd5 Dusp2 Pik3r3 Psmd7 Crk Pik3r1 Dusp5 Psmd8 Fgf10 Pik3r2 Dusp4 CELL-CELL COMMUNICATION%REACTOME DATABASE ID RELEASE 59%1500931 Cell-Cell communication Cd151 Itga6 Actn2 Ctnna1 Rsu1 Cadm2 Cadm1 Lims2 Ilk Rac1 Mapk8 F11r Pak1 Pard3 Crb3 Actn1 Kirrel2 Kirrel3 Sptan1 Cd2ap Cdh24 Actn4 Actn3 Prkci Col17a1 Wasl Tesk1 Lama3 Pard6b Fermt2 Dcc Pard6a Parvb Pard6g Parva Ptk2b Ptpn6 Ptpn11 Cldn6 Itgb4 Skap2 Itgb1 Cldn9 Cldn3 Cldn4 Cldn5 Ptk2 Pik3cb Sptbn1 Fyn Pik3ca Dscam Cadm3 Jup Ctnnd1 Cdh1 Cdh2 Cdh3 Cldn2 Cldn1 Cdh4 Cdh5 Cdh6 Cdh8 Flnc Cdh7 Flna Nck2 Cdh9 Sirpa Tyrobp Pxn Sirpb1b Cask Cldn23 Fyb Ntn1 Fblim1 Cldn22 Nck1 Cldn20 Ang Inadl Cldn19 Magi2 Cldn17 Plec Iqgap1 Pvrl4 Cldn18 Pvrl1 Pvrl2 Lamb3 Cldn16 Cldn10 Cldn15 Pvrl3 Cldn11 Cldn14 Cldn12 Vasp Mapk11 Cdh17 Mapk13 Mapk12 Mapk14 Cdh10 Cdh13 Cdh12 Cdh15 Arhgef6 Mpp5 Dscaml1 Pik3r1 Cdh11 Cldn8 Cldn7 Lamc2 Pik3r2 Cd47 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER%REACTOME DATABASE ID RELEASE 59%76061 RNA Polymerase III Transcription Initiation From Type 1 Promoter Polr2f Polr2e Polr2h Tbp Gtf3c1 Gtf3c6 Gtf3c3 Gtf3c2 Bdp1 Gtf3c4 Polr2k Crcp Polr3a Polr3gl Polr3k Polr3h Brf1 Polr3f Polr3g Gtf3c5 Polr1d Polr1c Polr3d Polr3e Polr3b Gtf3a Polr3c DIMERIZATION OF PROCASPASE-8%REACTOME DATABASE ID RELEASE 59%69416 Dimerization of procaspase-8 Fas Casp8 Fadd Tradd Fasl Ripk1 Tnfrsf10b Tnfsf10 Traf2 REGULATION OF KIT SIGNALING%REACTOME DATABASE ID RELEASE 59%1433559 Regulation of KIT signaling Fyn Prkca Yes1 Sos1 Lyn Sh2b3 Sh2b2 Cbl Lck Socs6 Socs1 Ptpn6 Kit TOLERANCE BY MTB TO NITRIC OXIDE PRODUCED BY MACROPHAGES%REACTOME%R-HSA-1222538.2 Tolerance by Mtb to nitric oxide produced by macrophages RECOGNITION AND ASSOCIATION OF DNA GLYCOSYLASE WITH SITE CONTAINING AN AFFECTED PYRIMIDINE%REACTOME DATABASE ID RELEASE 59%110328 Recognition and association of DNA glycosylase with site containing an affected pyrimidine Nthl1 Ogg1 Neil1 Mbd4 Neil2 Smug1 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF)%REACTOME%R-HSA-2559584.1 Formation of Senescence-Associated Heterochromatin Foci (SAHF) Hmga2 Trp53 Lmnb1 Ep400 Hmga1 Cabin1 Hist1h1d H1f0 Ubn1 Rb1 Hira Hist1h1c Asf1a Hist1h1e Hist1h1b Hist1h1a PTK6 REGULATES RHO GTPASES, RAS GTPASE AND MAP KINASES%REACTOME DATABASE ID RELEASE 59%8849471 PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases Dock1 Nf1 Dab2ip Nras Hras Rasal3 Rasa3 Rasa4 Pxn Rasal2 Rasa2 Rasa1 Rhoa Spred3 Spred2 Elmo1 Elmo2 Arhgap35 Spred1 Ptk6 Kras Rac1 Bcar1 Rasal1 Syngap1 Crk TRISTETRAPROLIN (TTP, ZFP36) BINDS AND DESTABILIZES MRNA%REACTOME%R-HSA-450513.2 Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA Zfp36 Ywhab Dcp1a Mapkapk2 Exosc9 Exosc8 Exosc7 Exosc5 Exosc4 Dcp2 Dis3 Xrn1 Exosc3 Tnpo1 Exosc1 Exosc2 NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION%REACTOME DATABASE ID RELEASE 59%164940 Nef mediated downregulation of MHC class I complex cell surface expression Ap1s2 Ap1b1 Ap1s1 Ap1g1 Pacs1 H2-Q10 Ap1s3 B2m Ap1m2 Ap1m1 L1CAM INTERACTIONS%REACTOME DATABASE ID RELEASE 59%373760 L1CAM interactions Itgb1 Ank1 Ank3 Nfasc Dlg4 Egfr Sptbn2 Itgb3 Sptbn1 Rac1 Pak1 Sptan1 Ranbp9 Scn1a Scn1b Shtn1 Nrcam Sptb Rdx Gap43 Scn2a1 Scn5a Lamc1 Map2k1 Ap2m1 Nrp1 Csnk2a2 Scn9a Hspa8 Itga2b Map2k2 Dlg1 Kcnq3 Nrp2 Sdcbp Cntnap1 Cntn6 Ap2a1 Dlg3 Kcnq2 Ap2a2 Msn Scn2b Cntn1 Cntn2 Lamb1 Sh3gl2 Itgav Dnm2 Scn10a Ncan Lypla2 Mapk3 Ephb2 Rps6ka5 Mapk1 Spta1 Ap2s1 Dnm1 Sptbn4 Chl1 Rps6ka6 Rps6ka4 Rps6ka3 Rps6ka2 Rps6ka1 Scn3a Scn3b Lama1 Scn11a L1cam Vav2 Clta Ap2b1 Csnk2b Ezr Ncam1 Alcam Kif4 Cltc Numb Scn7a Dnm3 Dpysl2 Itga1 Itga2 Scn8a Scn4b Itga9 Scn4a Itga10 Itga5 Dcx BETA OXIDATION OF DECANOYL-COA TO OCTANOYL-COA-COA%REACTOME DATABASE ID RELEASE 59%77346 Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA Echs1 Hadhb Acadm Hadha Hadh ECM PROTEOGLYCANS%REACTOME DATABASE ID RELEASE 59%3000178 ECM proteoglycans Agrn Itga7 Itga8 Itgb1 Tnr Serpine1 Tgfb3 Tgfb2 Lum Tnn Itgb3 Lama3 Lamc1 Bgn Dcn Bcan Itga2b Col9a1 Col9a2 Col9a3 Lamb1 Itgav Ncan Vcan Lama5 Lama2 Lama4 Matn1 Tnc Tgfb1 Musk Dmp1 Lama1 Hapln1 Lamb2 Dag1 Itgax Fmod Matn4 Matn3 Aspn Ncam1 Sparc Itgb6 Itgb5 Vtn Lrp4 Ibsp Dspp Tnxb Itga2 Itga9 Comp Ptprs CHK1 CHK2(CDS1) MEDIATED INACTIVATION OF CYCLIN B:CDK1 COMPLEX%REACTOME%R-HSA-75035.2 Chk1 Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex Ywhab Chek1 Wee1 Ywhaz Cdk1 Cdc25c Ywhah Sfn Ywhag Ywhae TNFR1-INDUCED PROAPOPTOTIC SIGNALING%REACTOME%R-HSA-5357786.2 TNFR1-induced proapoptotic signaling Casp8 Fadd Tnf Tradd Ripk1 Tnfaip3 Usp21 Otud7b Tnfrsf1a Usp2 Usp4 Cyld Traf2 GLUCAGON-TYPE LIGAND RECEPTORS%REACTOME%R-HSA-420092.1 Glucagon-type ligand receptors Gngt1 Gng7 Adcyap1r1 Gng4 Adcyap1 Gcg Gngt2 Glp1r Gng10 Gcgr Gng11 Gng13 Gng12 Gnb2 Gnb1 Gnb3 Gnb5 Ghrhr Gnb4 Ghrh Glp2r Gng8 Sct Gip Gng3 Gng2 Gipr CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE%REACTOME DATABASE ID RELEASE 59%176407 Conversion from APC C:Cdc20 to APC C:Cdh1 in late anaphase Cdc23 Ube2d1 Cdc27 Cdc14a Cdc16 Cdc20 Ube2c Anapc16 Ube2e1 Anapc7 Anapc4 Anapc5 Anapc1 Anapc2 Anapc15 Anapc11 Anapc10 Fzr1 REACTIONS SPECIFIC TO THE HYBRID N-GLYCAN SYNTHESIS PATHWAY%REACTOME DATABASE ID RELEASE 59%975574 Reactions specific to the hybrid N-glycan synthesis pathway Mgat3 CLEARANCE OF DOPAMINE%REACTOME%R-HSA-379401.2 Clearance of dopamine Comt Slc6a3 Maoa DEFECTIVE AVP CAUSES NEUROHYPOPHYSEAL DIABETES INSIPIDUS (NDI)%REACTOME DATABASE ID RELEASE 59%5619099 Defective AVP causes neurohypophyseal diabetes insipidus (NDI) Avp Avpr1a Avpr2 Avpr1b PDE3B SIGNALLING%REACTOME%R-HSA-165160.2 PDE3B signalling Pde3b Akt2 PHOSPHORYLATION SITE MUTANTS OF CTNNB1 ARE NOT TARGETED TO THE PROTEASOME BY THE DESTRUCTION COMPLEX%REACTOME DATABASE ID RELEASE 59%4839743 phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex Ppp2cb Ppp2r1b Apc Axin1 Ppp2ca Amer1 Csnk1a1 Ctnnb1 Gsk3b Ppp2r1a Ppp2r5b Ppp2r5e Ppp2r5c Ppp2r5d Ppp2r5a NEUROPHILIN INTERACTIONS WITH VEGF AND VEGFR%REACTOME DATABASE ID RELEASE 59%194306 Neurophilin interactions with VEGF and VEGFR Nrp1 Nrp2 Kdr Flt1 ABORTIVE ELONGATION OF HIV-1 TRANSCRIPT IN THE ABSENCE OF TAT%REACTOME%R-HSA-167242.2 Abortive elongation of HIV-1 transcript in the absence of Tat Polr2f Polr2i Polr2e Polr2j Polr2h Nelfa Nelfb Polr2c Polr2d Supt4a Polr2b Polr2g Polr2k Ctdp1 Polr2a Nelfe Supt5 Nelfcd Gtf2f1 Ncbp1 Ncbp2 Gtf2f2 GSD II%REACTOME DATABASE ID RELEASE 59%5357609 GSD II Gyg G0 AND EARLY G1%REACTOME DATABASE ID RELEASE 59%1538133 G0 and Early G1 Dyrk1a Pcna Lin9 Rbl2 Ccne1 Rbl1 Mybl2 Cdc6 Lin37 Cdk1 Cdk2 Lin54 E2f5 Ccne2 E2f4 Hdac1 E2f1 Ccna1 Rbbp4 Cdc25a Ccna2 Tfdp2 Lin52 Tfdp1 Top2a FGFR2 MUTANT RECEPTOR ACTIVATION%REACTOME%R-HSA-1839126.2 FGFR2 mutant receptor activation Fgf23 Fgf22 Fgf20 Fgf1 Fgf2 Fgf9 Fgf7 Fgf6 Fgf4 Fgf3 Polr2i Polr2f Polr2j Polr2e Polr2h Fgf16 Polr2c Polr2d Polr2b Fgf18 Polr2k Polr2g Polr2a Gtf2f1 Ncbp1 Fgf10 Ncbp2 Fgfr2 Gtf2f2 VITAMINS B6 ACTIVATION TO PYRIDOXAL PHOSPHATE%REACTOME%R-HSA-964975.1 Vitamins B6 activation to pyridoxal phosphate Pdxk Pnpo Aox1 MRNA 3'-END PROCESSING%REACTOME%R-HSA-72187.3 mRNA 3'-end processing Pabpn1 Srsf2 Thoc7 Thoc6 Srsf3 Slu7 Srsf11 Zc3h11a Magoh Cpsf1 Cstf1 Dhx38 Clp1 Thoc3 Srsf7 Thoc2 Thoc5 Thoc1 Srsf9 Ncbp1 Alyref Ncbp2 Srsf6 Nudt21 Cstf2t Fip1l1 Rbm8a Cstf3 Casc3 Sympk Eif4a3 U2af1l4 Chtop Srsf1 Cstf2 Cpsf3 Cpsf2 Cpsf4 Cpsf7 Ddx39b Upf3b Ddx39 Papola Fyttd1 Wdr33 Rnps1 Poldip3 Magohb Cdc40 Srrm1 MITOTIC METAPHASE AND ANAPHASE%REACTOME DATABASE ID RELEASE 59%2555396 Mitotic Metaphase and Anaphase Zw10 Ska1 Ankle2 Nup85 Pmf1 Nup160 Vrk1 Lmnb1 Spc25 Nudc Rps27 Ppp2r1a Spc24 Xpo1 Clasp2 Itgb3bp Nuf2 Cenpf Ppp1cc Cenpq Cenpp Ahctf1 Fbxo5 Cenpm Cenpl Cenpo Clip1 Cenpn Aurkb Zwilch Cdca8 Cenpt Apitd1 Sec13 Stag2 Sgol2b Ercc6l Stag1 Ppp2r2a Banf1 Dsn1 Nup107 Mad1l1 Pttg1 Smc1a Rad21 Cenph Cenpi Cenpe Cenpk Kif2c Taok1 Birc5 Kif2b Kif18a Bub1b Zwint Nup37 Incenp Wapal Psmd12 Nup43 Nup133 Psmd11 Rcc2 Nsl1 Kif2a Ndel1 Spdl1 Psmd14 Ndc80 Emd Kntc1 Psmd13 Bub3 Psmd10 Cdca5 Bub1 Cenpu Mad2l1 Casc5 Smc3 Cenpa Espl1 Lemd3 Lemd2 Cenpc1 Cdc23 Ppp2r1b Ube2d1 Cdc27 Cdc16 Cdc20 Ube2c Anapc16 Ube2e1 Anapc7 Anapc4 Shfm1 Anapc5 Anapc1 Anapc2 Sgol1 Pds5a Ranbp2 Mis12 Pds5b Pafah1b1 Psmc6 Psmc5 Psmc2 Psmd2 Psmb9 Psmf1 Psmb8 B9d2 Psme4 Ppp2r5e Ppp2r5c Ppp2r5d Ppp2r5a Psmc1 Psmc4 Psmc3 Psme3 Anapc15 Anapc11 Anapc10 Clasp1 Ppp2r5b Mapre1 Ppp2cb Ckap5 Ppp2ca Plk1 Psma7 Psma5 Psmb5 Psmb4 Ubc Psma4 Psma3 Psmb7 Psma6 Psmb6 Psmb2 Psmb3 Psma2 Psmb1 Psma1 Psmd9 Psmd1 Psme2 Psme1 Psmd3 Psmd4 Psmb10 Psmd6 Psmd5 Psmd7 Psmb11 Psmd8 DEFECTIVE EXT2 CAUSES EXOSTOSES 2%REACTOME%R-HSA-3656237.1 Defective EXT2 causes exostoses 2 Sdc3 Agrn Sdc4 Gpc6 Sdc2 Gpc3 Sdc1 Gpc5 Gpc2 Gpc4 Hspg2 Gpc1 SEMAPHORIN INTERACTIONS%REACTOME%R-HSA-373755.1 Semaphorin interactions Itgb1 Hsp90aa1 Rhoa Erbb2 Arhgap35 Fyn Rac1 Pak1 Tln1 Rhog Rhob Rock1 Rhoc Rock2 Nrp1 Sema6a Sema6d Myl6 Tyrobp Myh11 Dpysl5 Dpysl3 Farp2 Cd72 Myh14 Cdk5r1 Myh10 Dpysl4 Pip5k1c Ptprc Limk1 Arhgef11 Limk2 Arhgef12 Plxnd1 Plxnc1 Sema5a Trem2 Gsk3b Plxnb3 Rras Plxnb1 Met Pak3 Pak2 Crmp1 Rnd1 Myl12b Plxna2 Myl12a Sema3e Sema4a Rac2 Dpysl2 Sema4d Itga1 Hsp90ab1 Sema7a Fes Plxna4 Plxna3 Myh9 Cdk5 Plxna1 Sema3a ER QUALITY CONTROL COMPARTMENT (ERQC)%REACTOME%R-HSA-901032.5 ER Quality Control Compartment (ERQC) Os9 Rnf185 Derl2 Rnf5 Rnf139 Man1b1 Uggt2 Edem3 Amfr Trim13 Uggt1 Ubc Edem2 Edem1 Rnf103 Syvn1 Sel1l March6 ADENOSINE P1 RECEPTORS%REACTOME%R-HSA-417973.1 Adenosine P1 receptors Adora2b Adora2a Adora3 Adora1 ABACAVIR METABOLISM%REACTOME%R-HSA-2161541.3 Abacavir metabolism Guk1 Pck1 Adal Nt5c2 ERK MAPK TARGETS%REACTOME DATABASE ID RELEASE 59%198753 ERK MAPK targets Ppp2cb Ppp2r1b Dusp3 Mapk7 Dusp7 Rps6ka3 Dusp6 Rps6ka2 Ppp2ca Rps6ka1 Ppp2r1a Mapk11 Mapk14 Ppp2r5d Mapk3 Vrk3 Elk1 Rps6ka5 Mef2c Mapk1 Mef2a Dusp4 LOSS OF FUNCTION OF FBXW7 IN CANCER AND NOTCH1 SIGNALING%REACTOME DATABASE ID RELEASE 59%2644607 Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling Rbx1 Notch1 Skp1a Cul1 CITRIC ACID CYCLE (TCA CYCLE)%REACTOME%R-HSA-71403.1 Citric acid cycle (TCA cycle) Dld Ogdh Idh3g Sdhd Sdha Mdh2 Sdhc Suclg2 Suclg1 Sdhb Idh2 Idh3b Idh3a Fh1 Sucla2 Nnt Dlst Aco2 Cs SYNTHESIS OF DNA%REACTOME DATABASE ID RELEASE 59%69239 Synthesis of DNA Psmc6 Psmc5 Psmc2 Psmd2 Pcna Psmb9 Psmf1 Psmb8 Rb1 Rfc5 Psme4 Mcm6 Gins1 Rfc3 Cdc6 Cdk2 Mcm3 Mcm2 Mcm5 Mcm4 Rfc2 Ccna1 Psmc1 Gins4 Psmc4 Psmc3 Ccna2 Rfc4 Psme3 Gins2 Rfc1 Gins3 Fzr1 Orc4 Orc5 Mcm8 Mcm7 Pole Cdt1 Cdc45 Dna2 Pold1 Pold2 Pold3 Pold4 Orc2 Orc3 Orc6 Orc1 Prim1 Pole2 Rpa2 Rpa1 Cdkn1b Rpa3 Pola1 Pola2 Lig1 Fen1 Pole4 Prim2 Pole3 Cdkn1a Psmd12 Psma7 Psmd11 Psmd14 Psma5 Psmb5 Psmb4 Ubc Psmd13 Psma4 Psmd10 Psmb7 Psma3 Psma6 Psmb6 Psmb2 Psmb3 Psmb1 Psma2 Psma1 Psmd9 Psmd1 Shfm1 Psme2 Psme1 Psmd3 Psmd4 Psmb10 Psmd6 Psmd5 Psmd7 Psmb11 Psmd8 GENERIC TRANSCRIPTION PATHWAY%REACTOME%R-HSA-212436.3 Generic Transcription Pathway Serpine1 Rfc5 Rfc3 Rfc2 Rfc4 Dna2 Rpa2 Rpa1 Rpa3 Med1 Csnk2a2 Cox14 Trim28 Parp1 Cox11 Ccng1 Zfp111 Vegfa Trp73 Med4 Cox16 Sco1 Med8 Med6 Zfp46 Zfp398 Cox18 Csnk2b Notch1 Zfp708 Zfp707 Zfp706 Trp53rkb Zfp712 Zfp202 Helz2 Tsc2 Yeats4 Zfp141 Zfp212 Zfp418 Zfp710 Zfp558 Mlst8 Brpf3 Zfp819 Zfp711 Zfp551 Ccne1 Krba1 Mdm4 Egfr Brpf1 Ing5 Zfp867 Ccne2 Mtor Zfp213 Hdac1 Cox4i1 Ing2 Igfbp3 Nlrc4 Zfp566 Gls2 Maml2 Bid Hnf4a Hnf4g Polr2i Maml1 Polr2j Rptor Nelfa Zfp560 Nelfb Mnat1 Polr2c Map2k6 Polr2d Atrip Supt4a Zfp563 Polr2b Cnot11 Bcl2l14 Bard1 Zfp735 Zfp473 Zfp169 Nr4a2 Polr2g Cnot10 Chek2 Ctdp1 Zfp872 Nr5a1 Mre11a Zfp300 Zfp746 Zfp445 Zfp446 Men1 Polr2a Zfp740 Nelfe Zfp583 Supt5 Nelfcd Banp Kat2b Gtf2f1 Kat2a Zfp180 Cox8a Gtf2f2 Med20 mt-Co3 mt-Co2 E2f7 Cnot6l Med27 Cdkn1a Med26 Tpx2 Plk3 Rragd Rragb Rragc Rraga Med23 Med24 Med25 Ercc3 Cox7b Plk2 Rad1 Setd8 Nrbp1 Chm Zfp426 Rxrg Tbx5 Zfp324 Kit Fancd2 Havcr2 Apoe Zfp825 Ercc2 Ski Ppp2r1b Ube2d1 Ywhab Hipk1 Notch4 Ago2 Thrb Ago1 Rxrb Junb Tnrc6c Hipk2 Rxra Kat5 Gatad2a Carm1 Tnrc6b Gatad2b Zfp839 Notch3 Tnrc6a Thra Ago4 Notch2 Ago3 Zfp235 Zfp703 Cox5a Zfp157 Mdm2 Zfp334 Tmem55b Pten Pou4f1 Pou4f2 Casp6 Zfp709 Casp1 Casp2 Zfp704 Meaf6 Tbl1xr1 Kctd1 Rara Rarb Trp53bp2 Pidd1 Nr2c1 Nr2c2 Zfp90 Kat6a Prdx2 Zfp84 Prdx1 Ywhag Ccnc Tead3 Mapkapk5 Tead1 Tead2 Sp1 Zfp263 Bcl6 Mapkap1 Zfp266 Zkscan1 Ppp2r5c Cdk1 Zkscan6 Zkscan8 Pin1 Atp1b4 Tgif2 Zfp369 Tgif1 Rnf111 Yy1 Tnks1bp1 Zfp51 Triap1 Smyd2 Esrrb Esrra Ell Esrrg Phf20 Trp63 Taf9b Zfp69 Zkscan4 Zkscan5 Cox6a1 Gls Zkscan3 Atf2 Trim33 Crebbp Zfp382 Gpx2 Zfp113 Zfp112 Cdkn1b Apaf1 Fos Zfp37 Zfp248 Mlh1 Rgcc Nr4a1 Rbpj Prr5 Zfp30 Cox6b1 Cox20 Esr2 Zfp317 Zfp597 Chek1 Esr1 Zfp454 Ywhaz Atad2 Cdc25c Tmem219 Ywhah Btg2 Sfn Zfp750 Sgk1 Maml3 Zfp184 Rsph10b Cenpj Dyrk2 Zfp189 Zfp458 Mta2 Ube2d3 Blm Zfp1 Kdm5b Zfp2 Usp2 Hus1 Prmt5 Nr2c2ap Mdc1 Rarg Prmt1 Exo1 Brip1 Ndufa4 Pms2 Tfap2b Tfap2a Tigar Zik1 Nr2f1 Tfap2d Tfap2c Ak6 Tead4 Wrn Tfap2e Nr2f6 Zfp9 Gm28557 Jmy Brca1 Zfp287 Sesn2 Zfp286 Ccnh Pdpk1 Sesn3 Ccnk Mamld1 Zfp282 Zfp78 Ncoa1 Surf1 Nr2e1 Zfp74 Ncoa6 Ncoa2 Runx2 Zkscan17 Perp Zkscan16 Zkscan14 Nuak1 Pgr Prkaa2 Ar Cdk9 Zscan25 Trp53inp1 Ppp2r1a Cdk8 Ywhae Gata4 Skil Rffl Trex1 Rrm2b Taf1 Taf2 G6pdx Cdk12 Nr1h2 Ddit4 Cdk13 Rnf34 Prkaa1 Taf4b Taf7 Taf4a Taf5 Taf6 Taf3 Zfp13 Zfp14 Ddb2 Hdac2 Nbn Zfp11 Zfp12 Jun Smad4 Npm1 Smad2 Aurkb Smad7 Slmo1 Taf9 Aurka Smad3 Ccnt1 Zfp28 Zfp27 Nedd4l Atm Nkx2-5 Rqcd1 Ep300 Fancc Fanci Kctd15 Ube2i Rad17 Ccnt2 Nr0b2 Txnrd1 Prelid1 Med31 Birc5 Taf13 Taf11 Nr1d1 Tbl1x Med30 Pml Arid3a Rbbp8 Nr1d2 Gadd45a Tsc1 Pitx2 Rbbp7 Ctgf Taf12 Prkag2 Prkag1 Prkag3 Cnot4 Cnot7 Usp9x Cnot6 Cnot1 Cnot3 Brd7 Pcna Ppp1r13b Cnot2 Med13 Med14 Med12 Cnot8 Rbl2 Msh2 Rbl1 Med10 Mybl2 Ppp1r13l Bax Cdk2 Chd9 Ndrg1 E2f5 Med16 E2f4 Med17 E2f1 Ccna1 Rad50 Erbb2 Rbbp4 Med15 Chd3 Ccna2 Chd4 Tfdp2 Bnip3l Rorc Tfdp1 Ttc5 Zfp606 Zfp689 Rorb Zfp688 Rora Zfp605 Ncor1 Lrpprc Cradd Zfp697 Rabggta Ncor2 Zfp619 Mbd3 Zfp616 Rabggtb Zfp612 Hspd1 Steap3 Ssrp1 mt-Co1 Usp7 Zfp764 Zfp691 Zfp692 Lamtor1 Smarcd3 Top3a L3mbtl1 Gtf2h1 Ppard Zfp668 Gtf2h2 Ppp2cb Zfp664 Gtf2h5 Lamtor2 Ppm1a Gtf2h4 Txn1 Ppp2ca Ppara Lamtor5 Pparg Zfp661 Akt2 Wwox Akt3 Yap1 Topbp1 Zfp667 Cox7a2l Lamtor4 Gtf2h3 Zfp777 Rad9a Aifm2 Ubc Zfp775 Rad9b Myc Pcbp4 Nop2 Cdkn2a Wwtr1 Prdm1 Prkab1 Cdkn2b Akt1 Zfp385a Zfp677 Dek Cited1 Cited2 Stk11 Zfp786 Zfp770 Pip4k2b Zfp771 Pip4k2a Trp53 Prkab2 Tcea1 Pip4k2c Tceb1 Zfp354a Zfp641 Tceb3 Zfp647 Supt16 Taco1 Cited4 Vdr Rictor Ehmt2 Nppa Zfp354b Rad51d Zfp799 Zfp354c Gpi1 Cdk7 Daxx Smurf2 Zfp791 Zfp790 Zfp658 Ehmt1 Zfp655 Mov10 Tgfa Fas Tnfrsf10b Cdk5r1 Cdk5 Cga Polr2f Polr2e Polr2h Tbp Polr2k Mapk11 Mapk14 SIGNALING BY WNT IN CANCER%REACTOME DATABASE ID RELEASE 59%4791275 Signaling by WNT in cancer Ppp2cb Apc Axin1 Ppp2ca Amer1 Csnk1a1 Ctnnb1 Ppp2r1a Ppp2r5e Ppp2r5c Ppp2r5d Ppp2r5a Ppp2r1b Ctbp1 Porcn Ctbp2 Dkk1 Tnks Fzd6 Dkk2 Gsk3b Ppp2r5b Wnt3a Tnks2 Kremen2 Kremen1 Dkk4 Fzd4 Fzd5 Fzd8 Lrp6 Tcf7l2 Lrp5 Rnf43 TRAFFICKING OF AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 59%399719 Trafficking of AMPA receptors Akap5 Grip1 Cacng8 Gria2 Grip2 Cacng4 Prkcg Cacng3 Dlg1 Cacng2 Myo6 Nsf Tspan7 Camk2d Pick1 Gria3 Camk2a Gria4 Prkcb Ap2a1 Camk2b Prkca Dlg4 Camk2g Mdm2 Gria1 SIGNALLING TO ERK5%REACTOME%R-HSA-198765.1 Signalling to ERK5 Mapk7 Map2k5 HSF1-DEPENDENT TRANSACTIVATION%REACTOME%R-HSA-3371571.1 HSF1-dependent transactivation Dnajb1 Rptor Hsf1 Hsbp1 Hspa8 Camk2d Camk2a Hsp90aa1 Mlst8 Camk2b Crebbp Mtor Akt1s1 Ep300 Hsp90ab1 Hspa1a Hspa2 Camk2g Fkbp4 Cryab Hspa1l Hspb8 SIGNALING BY FGFR IN DISEASE%REACTOME%R-HSA-1226099.4 Signaling by FGFR in disease Fgf23 Fgf22 Fgf20 Frs2 Nras Stat5b Stat5a Hras Fgf1 Gab1 Fgf2 Fgf9 Fgf7 Fgf6 Fgf4 Fgf3 Polr2f Polr2i Polr2e Polr2j Polr2h Polr2c Stat1 Polr2d Polr2b Polr2g Polr2k Pik3ca Polr2a Fgfr1op Gtf2f1 Ncbp1 Ncbp2 Fgfr2 Gtf2f2 Bcr Fgfr1 Myo18a Trim24 Fgfr3 Bag4 Cux1 Fgfr4 Plcg1 Erlin2 Fgfr1op2 Stat3 Gab2 Cpsf6 Zmym2 Fgf16 Kras Fgf18 Sos1 Pik3r1 Fgf10 RECEPTOR-LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR%REACTOME DATABASE ID RELEASE 59%156988 Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor Adam10 Notch4 Ubc Notch1 Adam17 Jag2 Dll1 Notch3 Dll4 Jag1 Notch2 LOSS OF FUNCTION OF TGFBR2 IN CANCER%REACTOME DATABASE ID RELEASE 59%3642278 Loss of Function of TGFBR2 in Cancer Tgfbr1 Tgfb1 Fkbp1a Tgfbr2 FACILITATIVE NA+-INDEPENDENT GLUCOSE TRANSPORTERS%REACTOME DATABASE ID RELEASE 59%428790 Facilitative Na+-independent glucose transporters Slc2a6 Fgf21 Slc2a5 Slc2a9 Slc2a12 Slc2a4 Slc2a3 Slc2a10 Slc2a2 Slc2a1 Slc2a8 Slc2a7 LOSS OF FUNCTION OF SMAD4 IN CANCER%REACTOME DATABASE ID RELEASE 59%3304347 Loss of Function of SMAD4 in Cancer Smad4 Smad2 Smad3 SODIUM-COUPLED PHOSPHATE COTRANSPORTERS%REACTOME DATABASE ID RELEASE 59%427652 Sodium-coupled phosphate cotransporters Slc34a2 Slc34a1 Slc34a3 Slc20a1 Slc20a2 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS)%REACTOME DATABASE ID RELEASE 59%456926 Thrombin signalling through proteinase activated receptors (PARs) Gngt1 Gng7 Gng4 Gngt2 F2rl3 F2rl2 Gng10 Arrb2 Arrb1 Mapk3 Mapk1 Gng11 Gng13 Gng12 Gnb2 Gnb1 Gnb3 Gnb5 Gnb4 Gna11 Gna12 Gng8 F2r Gnaq Gna15 F2 Gng3 Gng2 Gna13 Gna14 DEFECTIVE CHST6 CAUSES MCDC1%REACTOME DATABASE ID RELEASE 59%3656225 Defective CHST6 causes MCDC1 Omd Prelp Kera Lum Ogn Fmod PENTOSE PHOSPHATE PATHWAY (HEXOSE MONOPHOSPHATE SHUNT)%REACTOME DATABASE ID RELEASE 59%71336 Pentose phosphate pathway (hexose monophosphate shunt) Rpia Pgm1 Pgls Tkt G6pdx Pgd Rpe Dera Taldo1 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 59%69613 p53-Independent G1 S DNA damage checkpoint Psmc6 Psmc5 Psmc2 Psmd2 Psmb9 Psmb8 Psmf1 Psme4 Psmc1 Psmc4 Psmc3 Cdc25a Psme3 Chek2 Atm Chek1 Psmd12 Psmd11 Psma7 Psmd14 Psma5 Psmb5 Psmb4 Psmd13 Ubc Psmd10 Psma4 Psma3 Psmb7 Psma6 Psmb6 Psmb2 Psmb3 Psma2 Psmb1 Psma1 Psmd9 Psmd1 Psme2 Shfm1 Psme1 Psmd3 Psmd4 Psmb10 Psmd6 Psmd5 Psmd7 Psmb11 Psmd8 PYRIMIDINE CATABOLISM%REACTOME DATABASE ID RELEASE 59%73621 Pyrimidine catabolism Tymp Upp2 Upp1 Agxt2 Nt5m Nt5c1a Nt5e Nt5c Upb1 Dpyd Dpys ATF4 ACTIVATES GENES%REACTOME%R-HSA-380994.1 ATF4 activates genes Ddit3 Nfyb Herpud1 Nfyc Exosc9 Exosc8 Exosc7 Exosc5 Exosc4 Parn Atf6 Igfbp1 Atf3 Atf4 Nfya Asns Ccl12 Dcp2 Dis3 Exosc3 Exosc1 Exosc2 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1%REACTOME DATABASE ID RELEASE 59%937041 IKK complex recruitment mediated by RIP1 Ube2d1 Ticam2 Ripk3 Birc3 Chuk Birc2 Ripk1 Ticam1 Traf6 Ikbkb Ube2v1 Tlr4 Ube2n Tlr3 Ly96 Cd14 Ikbkg Ube2d3 Ubc PKB-MEDIATED EVENTS%REACTOME%R-HSA-109703.3 PKB-mediated events Prkag2 Pde3b Prkag1 Prkag3 Ppm1a Lamtor2 Prkaa2 Lamtor5 Tsc2 Akt2 Rragd Rragb Rragc Rraga Tsc1 Eif4b Mlst8 Lamtor4 Mtor Akt1s1 Prkaa1 Prkab1 Akt1 Ywhab Stk11 Rptor Prkab2 Cab39 Eif4e Strada Stradb Cab39l Eef2k Eif4g1 Eif4ebp1 Lamtor1 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION%REACTOME DATABASE ID RELEASE 59%156827 L13a-mediated translational silencing of Ceruloplasmin expression Rpl39 Rplp1 Eif2s1 Eif2s2 Eif3i Eif3k Eif3l Eif3m Rpl7 Rps21 Rplp2 Rps27 Eif3a Eif3b Eif3c Rps25 Rpl4 Eif3d Rps26 Rps27l Eif3e Rpl18a Rpl34 Rpl32 Eif3f Eif3h Eif3g Rpl26 Rpl24 Rps9 Eif2s3x Rps7 Rps5 Rpsa Rpl37 Rps4x Eif4b Eif4a1 Eif4a2 Rpl22 Eif1ax Rpl10l Rpl23 Rpl39l Eif3j2 Rpl13a Rpl22l1 Rps15a Rpl11 Rpl17 Rps3 Rpl19 Rpl18 Rps16 Eif4e Rps14 Rps19 Rps18 Eif4h Pabpc1 Rps11 Eif4g1 Rps10 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE%REACTOME%R-HSA-168142.1 Toll Like Receptor 10 (TLR10) Cascade Ppp2r1a Btrc Mapk9 Nfkb2 Nfkb1 Ecsit Fbxw11 Skp1a Saa3 Ppp2r5d Mapkapk3 Tnip2 Myd88 Nod2 Cul1 Nod1 Dhx9 Vrk3 S100b Elk1 Mef2c Mapk10 Mef2a Tlr5 Map3k7 Dusp3 Mapk7 Peli1 Creb1 Mapkapk2 Irak2 Irak1 App Map2k6 Tab1 Tab2 Jun Mapk8 Tab3 Map3k1 Ripk2 Map2k7 Ager Map2k3 Map2k4 Map3k8 Atf2 Rela Nfkbia Peli3 Nfkbib Irak4 Fos Peli2 Ppp2cb Map2k1 Chuk Ppp2ca Ubc Mapk3 Rps6ka5 Mapk1 Ppp2r1b Dusp7 Rps6ka3 Dusp6 Rps6ka2 Rps6ka1 Traf6 Ikbkb Ube2v1 Ube2n Ikbkg Mapk11 Mapk14 Dusp4 TRANSFERRIN ENDOCYTOSIS AND RECYCLING%REACTOME%R-HSA-917977.1 Transferrin endocytosis and recycling Atp6v0d2 Atp6v0d1 Atp6v0b Atp6v1c2 Atp6v1c1 Mcoln1 Steap2 Atp6v0e Atp6ap1 Atp6v1g3 Atp6v1e2 Tfrc Atp6v1e1 Atp6v0e2 Atp6v1a Atp6v1b1 Tcirg1 Trf Atp6v1b2 Atp6v1g1 Atp6v1g2 Atp6v0a1 Atp6v0a2 Atp6v1h Atp6v0a4 Steap3 Atp6v1d Atp6v1f SMAC BINDS TO IAPS%REACTOME DATABASE ID RELEASE 59%111463 SMAC binds to IAPs Casp3 Diablo Casp9 Casp7 Xiap METABOLISM OF VITAMIN K%REACTOME DATABASE ID RELEASE 59%6806664 Metabolism of vitamin K Vkorc1 Vkorc1l1 Ubiad1 SIGNALING BY RHO GTPASES%REACTOME DATABASE ID RELEASE 59%194315 Signaling by Rho GTPases Zw10 Dvl1 Pik3c3 Ska1 Akap13 Arhgap11a Nup85 Depdc7 Pmf1 Iqgap3 Nup160 Iqgap2 Ar Mkl1 Spc25 Dvl3 Actb Nudc Ppp2r1a Rps27 Pik3r4 Ywhae Spc24 Kdm4c Xpo1 Scai Clasp2 Kif14 Itgb3bp Ect2 Nuf2 Dvl2 Wipf3 Wipf2 Pfn2 Pfn1 Rhof Rhoh Wipf1 Srf Wasf2 Rhod Arhgdig Wasf3 Arpc5 Arpc4 H2afj Wasf1 H2afb2 Cenpf Ctnna1 Diap1 Ppp1cc Diap3 Cenpq Myo9b Cenpp Arhgap17 Ahctf1 Cybb Cyba Cenpm Rac1 Arhgap18 Cenpl Cenpo Arhgap12 Clip1 Arhgap19 Pak1 Cenpn Klc3 Klc2 Aurkb Zwilch Klc4 Arhgef10l Cdca8 Cenpt Gmip Arhgap15 Apitd1 Sos2 Kdm1a Sgol2b Racgap1 Ercc6l Fam13b Rtkn Hist2h2be Wasl Dsn1 Was Trio Nup107 Mad1l1 Syde2 Syde1 Hist2h2ac Dlc1 Cenph Ocrl Cenpi H3f3b Cenpe H3f3a Cenpk Inpp5b Hist1h2bg Kif2c Taok1 Hist1h2bh Birc5 Srgap2 Rhobtb2 Kif2b Arhgap39 Kif18a Actg1 Bub1b Rhobtb1 Zwint Depdc1b Nup37 Hist1h2bp Incenp Hist1h2bm Nup43 Ppp1r14a Nup133 Daam1 Rcc2 Hist1h2bj Srgap3 Nsl1 Hist1h2bb Kif2a Ndel1 Srgap1 Spdl1 Gdi2 Ndc80 Gdi1 Mcf2 Hmha1 Kntc1 Nckap1l Bub3 Mcf2l Arhgap10 Bub1 Noxa1 Cenpu Arhgap22 Mad2l1 Arhgap21 Casc5 Trip10 Cenpa Klc1 Myo9a Arhgap20 Abi1 Abi2 Cenpc1 Arhgap26 Cttn Arhgef7 Arpc1a Arhgap31 Arhgap32 Arpc1b Arhgap25 Arhgef3 Arhgef4 Arhgef1 Arhgef2 Vav2 Hist1h3d Arhgap23 Arhgap29 Arhgap24 Arhgef9 Nckap1 Sgol1 Prex1 Hist1h2ak Noxo1 Ranbp2 Arhgap28 Mis12 Hist1h2ag Ppp1r12b Arhgap40 Arhgap42 Arhgap44 Arhgap36 Itsn1 Cyfip1 Hist1h2ah Cyfip2 Rhpn2 Ncf4 Hist2h3c1 Ppp1r12a Arhgap33 Ncf2 Rhpn1 Ncf1 Ptk2 Rhog Rhob Rock1 Gna13 Rhoc Rock2 Ppp2cb Ppp2ca Bcr Nck1 Mapk3 Mapk1 Sos1 Vav1 Rhoa Arhgap35 Sec13 Men1 Ctnnb1 Myl6 Myh11 Myh14 Myh10 Ppp2r1b Ywhab Limk1 Arhgef11 Limk2 Arhgef12 Cdc20 Pak3 Pak2 Myl12b Myl12a Rac2 Myh9 Pafah1b1 Itgb1 Ywhag B9d2 Ppp2r5e Dlg4 Ppp2r5c Ppp2r5d Ppp2r5a Clasp1 Ngef Ppp2r5b Arhgef26 Mapre1 Fgd2 Net1 A2m Fgd4 Cdkn1b Hist3h2ba Fgd1 Fgd3 Stard13 Abl1 Arhgef17 Arhgef10 Vav3 Nox3 Nox1 Cit Plekhg5 Arhgef19 Arhgef16 Arhgef15 Cdh1 Ywhaz Nf2 Ckap5 Cdc25c Abr Ywhah Arhgef18 Sfn Plekhg2 Arhgef40 Arap3 Plk1 Btk Cftr Ophn1 Stard8 Arap2 Flna Arap1 Arhgef38 Arhgef39 Gopc Rac3 Ppp1cb Fmnl2 Fmnl3 Arhgef37 H2afz Baiap2 H2afx Fmnl1 Brk1 Pkn2 Pkn1 Evl Tiam2 Tiam1 Pkn3 Iqgap1 Actr2 Actr3 Lin7b Hist2h2aa1 Kif5a Kif5b Kalrn Mylk Rhot1 Rhot2 Nckipsd Arhgap8 Arhgap9 Arhgap1 Ropn1 Arhgap5 Arhgap4 Pdpk1 Arhgdib Arhgap6 Arhgdia Rhoj Arhgef6 Arpc3 Prc1 Ktn1 Arpc2 Ralbp1 Rhoq Ncoa2 Rhou Pik3r2 Rhov E2F MEDIATED REGULATION OF DNA REPLICATION%REACTOME%R-HSA-113510.2 E2F mediated regulation of DNA replication Ppp2cb Ppp2ca Ppp2r1a Pcna Rb1 Ccne1 Cdc6 Cdk1 E2f1 Ccna1 Rrm2 Tyms Cdc25a Dhfr Tk2 Tfdp2 Tfdp1 Ppp2r1b Orc4 Orc5 Mcm8 Cdt1 Fbxo5 Cdc45 Orc2 Orc3 Orc6 Orc1 Prim1 Pola1 Pola2 Prim2 SMAD4 MH2 DOMAIN MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 59%3311021 SMAD4 MH2 Domain Mutants in Cancer Smad4 Smad2 Smad3 AKT-MEDIATED INACTIVATION OF FOXO1A%REACTOME%R-HSA-211163.1 AKT-mediated inactivation of FOXO1A Akt2 Akt3 Akt1 Foxo1 MITOTIC G2-G2 M PHASES%REACTOME DATABASE ID RELEASE 59%453274 Mitotic G2-G2 M phases Akap9 Ppp2r1a Ywhae Xpo1 Ninl Cep152 Btrc Lin37 Fbxw11 Lin54 Cenpf Mnat1 Aurka Ppp2r2a Ep300 Rbx1 Cdkn1a Tpx2 Psmd12 Psmd11 Psmd14 Psmd13 Psmd10 Ppp2r1b Shfm1 Hsp90ab1 Pafah1b1 Psmc6 Psmc5 Ccp110 Nek2 Cep57 Psmc2 Psmd2 Haus7 Haus8 Ywhag Lin9 Psmb9 Hsp90aa1 Psmf1 Psmb8 Ywhaq Rab8a Psme4 Prkar2b Mybl2 Haus3 Ppp1r12a Haus4 Cdk2 Cdk1 Skp1a Cetn2 E2f1 Ccna1 Psmc1 Ofd1 Psmc4 Rbbp4 Haus2 Cdc25a Psmc3 Cep63 Cul1 Ccna2 Alms1 Psme3 Haus5 Lin52 Haus6 Haus1 Tubg2 Tubb4a Optn Tubb4b Numa1 Ccnb2 Phlda1 Clasp1 Gtse1 Ssna1 Cdc25b Tubg1 Pkmyt1 Csnk1d Cep250 Tuba4a E2f3 Dynll1 Cdk11b Csnk1e Tubgcp5 Cep135 Tubgcp4 Tubgcp3 Cdk5rap2 Mapre1 Pcnt Sfi1 Cep70 Nedd1 Actr1a Cep131 Pcm1 Tubgcp2 Prkaca Hmmr Dync1i2 Ajuba Fgfr1op Foxm1 Fbxl7 Cep76 Fkbpl Cep78 Cep72 Fbxl18 Bora Dctn2 Ppp2cb Dctn3 Wee1 Ckap5 Cep164 Ppp2ca Cdc25c Tubb5 Tuba1a Cep41 Plk1 Psma7 Cenpj Dync1h1 Psma5 Plk4 Psmb5 Sdccag8 Psmb4 Ubc Psma4 Ppp1cb Psma3 Psmb7 Psma6 Psmb6 Psmb2 Psmb3 Psma2 Psmb1 Psma1 Psmd9 Trp53 Psmd1 Psme2 Psme1 Psmd3 Psmd4 Psmb10 Ccnh Psmd6 Psmd5 Cdk7 Psmd7 Psmb11 Psmd8 METHIONINE SALVAGE PATHWAY%REACTOME DATABASE ID RELEASE 59%1237112 Methionine salvage pathway Mri1 Adi1 Got1 Enoph1 Apip Mtap DOPAMINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME%R-HSA-212676.2 Dopamine Neurotransmitter Release Cycle Lin7b Snap25 Ppfia2 Ppfia1 Apba1 Ppfia4 Syn3 Cask Unc13b Syn1 Syn2 Rab3a Syt1 Slc18a2 Vamp2 Lin7c Cplx1 Lin7a Stx1a CATECHOLAMINE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 59%209905 Catecholamine biosynthesis Ddc Th Dbh Pnmt FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION%REACTOME%R-HSA-983231.2 Factors involved in megakaryocyte development and platelet production Dock1 Gata4 Hdac1 Hdac2 Rac1 Klc3 Klc2 Klc4 Kdm1a Racgap1 Ep300 H3f3b H3f3a Cenpe Dock5 Kif2c Dock6 Dock3 Dock4 Kif2b Kif18a Rab5a Gata2 Kif3c Rcor1 Kif3b Kif3a Dock7 Kif2a Dock8 Kif18b Capza1 Sh2b3 Capza2 Capzb Sh2b2 Gata5 Gata6 Gata3 Gata1 Dock11 Dock10 Kifc5b Klc1 Sh2b1 Kifc2 Ifnb1 Lrrc16a Akap1 Cables1 Hmg20b Kif16b Kif26a Cables2 Ehd3 Ehd2 Ehd1 Mafg Maff Vps45 Hbb-bh1 Hist1h3d Kif26b Dock2 Kif13b Mafk Kif20b Cbx5 Kif4 Mfn2 Kif20a Itpk1 Myb Kifap3 Sin3a Nfe2 Kif22 Akap10 Hbb-bt Kif27 Cdk5 Mfn1 Kif23 Kif9 Rbsn Irf7 Irf1 Ak3 Kif12 Kif15 Kif19a Prkar2a Kif6 Kif1c Kif21a Kif21b Prkacb Hbb-bs Kif1b Kif1a Irf2 Irf3 Prkar2b Hist2h3c1 Cdk2 Jmjd1c Rad51b Rad51c Kif11 Zfpm1 Hbb-y Ifna16 Zfpm2 Crebbp Prkar1a Prkar1b Prkaca Abl1 Wee1 Jak2 Trp53 Kif5a Kif5b SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS%REACTOME%R-HSA-75876.4 Synthesis of very long-chain fatty acyl-CoAs Ppt2 Hsd17b3 Hacd2 Hacd3 Hacd1 Ppt1 Acsl3 Acsf3 Hsd17b12 Hacd4 Acsbg1 Acsl6 Acsl5 Acsl4 Elovl7 Acsbg2 Slc27a3 Acsl1 Elovl6 Tecr Tecrl Elovl1 Elovl5 Elovl4 Elovl3 Elovl2 FOLDING OF ACTIN BY CCT TRIC%REACTOME%R-HSA-390450.1 Folding of actin by CCT TriC Cct2 Cct5 Cct6b Tcp1 Cct8 Cct3 Cct4 Cct7 Actb INTERACTIONS OF NEUREXINS AND NEUROLIGINS AT SYNAPSES%REACTOME DATABASE ID RELEASE 59%6794361 Interactions of neurexins and neuroligins at synapses Grin1 Dlg4 Syt10 Dlgap4 Nlgn3 Syt12 Grin2c Dlgap1 Apba2 Dlgap3 Dlgap2 Shank1 Dlg2 Shank3 Nrxn2 Nlgn1 Nlgn2 Dbnl Homer3 Syt9 Syt7 Nrxn1 Epb4.1 Begain Syt2 Grin2d Grin2b Dlg3 Epb4.1l3 Stxbp1 Epb4.1l2 Epb4.1l5 Grm1 Cask Sipa1l1 Grm5 Lrrtm3 Sharpin Lrrtm1 Lrrtm2 Pdlim5 Apba3 Grin2a Homer1 Homer2 Lin7b Apba1 Syt1 Lin7c Lin7a Stx1a COMMON PATHWAY OF FIBRIN CLOT FORMATION%REACTOME DATABASE ID RELEASE 59%140875 Common Pathway of Fibrin Clot Formation F13a1 Procr F10 Pros1 Fgg Thbd F5 Prtn3 Serpine2 F8 F13b Cd177 Pf4 Serpina5 Proc Serpind1 Fga Serpinc1 Fgb F2r F2 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION%REACTOME%R-HSA-69202.3 Cyclin E associated events during G1 S transition Psmc6 Psmc5 Psmc2 Psmd2 Psmb9 Psmb8 Psmf1 Rb1 Ccne1 Cdk2 Skp1a Ccne2 Psmc1 Ccna1 Psmc4 Skp2 Psmc3 Cdc25a Cul1 Ccna2 Cdk4 Psme3 Cks1b Max Ccnd1 Ptk6 Mnat1 Cdkn1b Wee1 Cdkn1a Akt2 Akt3 Psmd12 Psma7 Psmd11 Psmd14 Psma5 Psmb5 Psmb4 Psmd13 Ubc Psmd10 Psma4 Myc Psmb7 Psma3 Psma6 Psmb6 Psmb2 Psmb3 Psmb1 Psma2 Psma1 Akt1 Psmd9 Psmd1 Shfm1 Psme2 Psme1 Psmd3 Psmd4 Psmb10 Ccnh Psmd6 Psmd5 Cdk7 Psmd7 Psmd8 ER-PHAGOSOME PATHWAY%REACTOME DATABASE ID RELEASE 59%1236974 ER-Phagosome pathway Psmc6 Psmc5 Psmc2 Psmd2 Psmb9 Psmf1 Psmb8 Psme4 Psmc1 Psmc4 Myd88 Psmc3 Psme3 Sec22b H2-M3 H2-M5 Vamp8 Chuk Sec61a2 Vamp3 H2-Q1 Stx4a Calr Tapbp Psmd12 Btk Tlr2 Psma7 Psmd11 Tlr6 Sec61g Sec61a1 Sec61b Pdia3 Psmd14 Psma5 Psmb5 Psmb4 Ubc Psmd13 Psmd10 Psma4 Psmb7 Psma3 Psma6 Psmb6 Psmb2 Psmb3 Psmb1 Psma2 Psma1 Psmd9 Ikbkb Tlr4 Psmd1 Shfm1 Psme2 Ly96 Cd14 Psme1 Ikbkg Psmd3 Psmd4 Cd36 Snap23 Psmb10 Psmd6 Tap1 H2-Q10 Psmd5 Tap2 Tlr1 Tirap Psmd7 Psmb11 Psmd8 B2m POST-ELONGATION PROCESSING OF THE TRANSCRIPT%REACTOME%R-HSA-76044.2 Post-Elongation Processing of the Transcript Pabpn1 Srsf2 Thoc7 Thoc6 Srsf3 Zfp473 Slu7 Srsf11 Zc3h11a Magoh Cpsf1 Cstf1 Dhx38 Clp1 Thoc3 Srsf7 Thoc2 Thoc5 Thoc1 Srsf9 Ncbp1 Alyref Ncbp2 Srsf6 Nudt21 Cstf2t Fip1l1 Rbm8a Cstf3 Casc3 Sympk Eif4a3 U2af1l4 Chtop Srsf1 Cstf2 Cpsf3 Cpsf2 Cpsf4 Cpsf7 Lsm11 Ddx39b Upf3b Ddx39 Papola Fyttd1 Wdr33 Rnps1 Poldip3 Lsm10 Magohb Snrpb Snrpd3 Cdc40 Slbp Srrm1 SCAVENGING BY CLASS A RECEPTORS%REACTOME DATABASE ID RELEASE 59%3000480 Scavenging by Class A Receptors Col3a1 Hsp90b1 Fth1 Scgb3a2 Ftl1 Colec11 Colec12 Marco Calr Col4a2 Col4a1 Scara5 Col1a2 Col1a1 Apoe Apoa1 Apob Msr1 PURINE METABOLISM%REACTOME%R-HSA-73847.2 Purine metabolism Adss Ampd1 Gmpr Hprt Atic Aprt Pnp Ppat Cat Ada Paics Pfas Gpx1 Ampd2 Dck Ampd3 Adk Adssl1 Adsl Dguok Gart Impdh1 Gda Gmpr2 Xdh Lhpp Gmps Adal Nt5c2 Nt5c1a Nt5e Nt5c ALTERNATIVE COMPLEMENT ACTIVATION%REACTOME DATABASE ID RELEASE 59%173736 Alternative complement activation Cfb Cfd C3 Gzmm GPCR DOWNSTREAM SIGNALING%REACTOME DATABASE ID RELEASE 59%388396 GPCR downstream signaling Prkcb Vav2 F2rl3 F2rl2 Gna11 Gna12 F2r Gnaq Gna15 F2 Gna13 Gna14 Gab2 Pde3b Avp Avpr1a Avpr2 Avpr1b Gngt1 Gng7 Adcyap1r1 Gng4 Adcyap1 Gcg Gngt2 Glp1r Gng10 Gcgr Gng11 Gng13 Gng12 Gnb2 Gnb1 Gnb3 Gnb5 Ghrhr Gnb4 Ghrh Glp2r Gng8 Sct Gip Gng3 Gng2 Gipr C3 Rac1 Adcy7 Adcy6 Adcy5 Adcy4 Adcy3 Adcy2 Adcy1 Adcy9 Pf4 Adcy8 Il5ra Shc1 Akt2 Akt3 Grm1 Grm5 Akt1 Pde1b Pde1a Sos1 Csf2rb2 Csf2ra Rhoa Arhgef6 Akap13 Ect2 Arhgef10l Sos2 Trio Mcf2 Mcf2l Arhgef7 Arhgef3 Arhgef4 Arhgef1 Arhgef2 Arhgef9 Prex1 Itsn1 Olfr1156 Olfr1157 Olfr1052 Olfr1155 Olfr631 Olfr1357 Olfr635 Olfr1352 Olfr1162 Olfr18 Olfr1356 Gal Gpr27 Gpr25 Olfr16 Olfr17 Gpr4 Oxt Olfr1093 Htr5a Npy1r Kiss1r Gpsm1 Olfr1094 Rho F2rl1 Grpr Ptgdr Rgr Adm2 Mc5r Ptgfr Ntsr1 Ntsr2 Sucnr1 Ghsr Uts2b Npy5r Uts2r Taar8b Npy4r Taar1 Taar2 Taar5 Taar6 Pnoc Taar9 Npy2r Casr Olfr231 Ptgdr2 Adora2b Trh Adora2a Opn1sw Adora3 Mc2r Adora1 Olfr919 Fshr Adrb2 Fshb C5ar1 Rhog Adrb1 Edn1 Rhob Adrb3 Rock1 Rhoc Edn3 Rock2 Edn2 Gpha2 Mc1r Olfr222 Olfr220 Ptgir Olfr221 Lpar5 Oxgr1 P2ry13 P2ry12 P2ry14 P2ry10 Olfr421-ps1 Olfr229 Ramp1 Brs3 Ccr9 Ccr8 Ccr7 Ccr6 Ccr4 Ccr3 Mc3r Calcrl Lpar6 Mc4r Ccr10 Ramp2 Ramp3 Vipr2 Olfr211 Vipr1 Olfr685 Olfr684 Prkcd Olfr683 Prkce Reep5 Reep4 Reep3 Prkcg Pth2r Tas2r118 Tas2r126 Olfr410 Olfr411 Olfr412 Tas2r121 Tas2r120 Olfr414 Prkca Reep1 Vav1 Dgkb Npff Il2rg Olfr677 Arrb2 Dgka Pde10a Olfr1311 Arrb1 Olfr478 Olfr675 Olfr687 Adrbk1 Reep2 Reep6 Tas2r119 Olfr402 Olfr681 Dgke Dgkg Iapp Gper1 Pth1r Tas2r108 Olfr175-ps1 Ccl25 Olfr821 Ccl28 Galr2 Htr2a Agtr2 Olfr32 Htr2b Tas2r107 Htr2c Olfr1385 Rrh Olfr419 Rasgrp2 Olfr417 Olfr809 Olfr808 Olfr692 Olfr691 Olfr429 Olfr430 Olfr825 Olfr298 Olfr420 Olfr288 Agtr1a Olfr832 Olfr1500 Htr1d Olfr20 Olfr24 Olfr1509 Pmch Olfr1505 Htr1f Olfr57 Olfr55 Gpr18 Qrfp Hcrtr1 Hcrtr2 Olfr1512 Olfr1511 Htr7 Olfr31 Galr1 Htr6 Fpr3 Il2 Olfr1102 Htr4 Olfr1100 Pomc Gpr17 Fpr2 Olfr1104 Htr1b Olfr26 Gpr15 Il5 Htr1a P2ry1 Rgs4 P2ry2 Rgs5 Rgs7 Rgs6 Rgs9 Rgs8 C3ar1 Gpr55 Olfr1360 Olfr618 Olfr11 Gpr20 Olfr15 Olfr13 Itpr1 Olfr1123 Olfr43 Olfr44 Olfr47 Olfr1396 Gast Olfr1111 Npffr1 Il3ra Cck Npffr2 Gpr45 Il2ra Rgs1 Il2rb Itpr3 P2ry6 Rgs2 Itpr2 Rgs3 P2ry4 Grp Rtp2 Abhd12 Tbxa2r Crhr2 Crhr1 Tas2r137 Tas2r136 Tas2r135 Sst Nmb Ackr3 Tas2r131 Tas2r130 Tas2r138 Tas2r139 Nmu Chrm3 Chrm2 Chrm1 Trhr Nms Gprc6a Pik3r6 Pik3r5 Kiss1 Chrm5 Pik3cb Crh Chrm4 Pik3cd Tas2r140 Calcr Tas2r144 Gnai2 Gnai1 Olfr376 Xcr1 S1pr5 Gnai3 Olfr370 Olfr372 S1pr2 S1pr3 S1pr1 S1pr4 Ngef Sstr2 Rasgrp1 Sstr1 Opn3 Pik3ca Opn4 Arhgef26 Sstr5 Npbwr1 Fgd2 Net1 Sstr3 Sstr4 Ppy Fgd4 Cort Opn5 Fgd1 Npb Fgd3 Lhcgr Npy Arhgef17 Npw Arhgef10 Nmbr Vav3 Rtp4 Rtp3 Nps Rtp1 Plekhg5 Olfr448 Arhgef19 Olfr648 Arhgef16 Olfr447 Arhgef15 Olfr263 Olfr444 Abr Jak2 Olfr646 Arhgef18 Dgkq Plekhg2 Olfr1309 Arhgef40 Lpar3 Jak3 Lpar4 Lpar1 Lpar2 Dgkh Olfr446 Olfr267 Dgki Arhgef38 Gcat Arhgef39 Olfr365 Olfr362 Olfr101 Ltb4r2 Olfr368 Oprd1 Arhgef37 Ltb4r1 Olfr110 Pdyn Cxcl16 Cxcl13 Olfr109 Pthlh Cxcl12 Cxcl11 Olfr669 Tiam2 Olfr464 Tiam1 Gpr68 Gpr65 Olfr666 Olfr870 Olfr874 Olfr867 Olfr658 Kalrn Olfr453 Cnr2 Abhd6 Olfr878 Olfr243 Olfr460 Olfr463 Gpr83 Olfr854 Olfr272 Pdpk1 Olfr275 Olfr270 Olfr273 Cnr1 Pik3r3 Olfr452 Dgkz Pde11a Pik3r1 Olfr449 Olfr640 Olfr641 Adrbk2 Pik3r2 Gpr84 Olfr853 Olfr1256 Olfr1259 Trpc6 Ffar3 Pde4d Pde4c Olfr1258 Gpr150 Olfr1193 Nts Oprk1 Olfr1014 Rxfp1 Rxfp2 Gpbar1 Olfr1019 Olfr1020 Arhgef25 Rxfp4 Rxfp3 Ptger3 Olfr1023 Ptger4 Saa3 Olfr1022 Cxcl2 Ptger1 Ptger2 Olfr1029 Olfr1032 Olfr1031 Cxcl9 Cxcl5 Vip Olfr796 Grm7 Grm8 Grm2 App Grm3 Grm4 Hc Olfr504 Olfr508 Olfr1288 Olfr780 Olfr782 Olfr786 Olfr788 Olfr516 Gpr132 Olfr518 Prok1 Olfr1469 Csf2 Mchr1 Prok2 Hebp1 Olfr1461 Olfr1264 Olfr1265 Trpc3 Olfr1451 Ffar2 Olfr1252 Ffar1 Trpc7 Olfr1006 Ccl5 Cxcr1 Daglb Olfr63 Jak1 Pde7b Fpr1 Olfr64 Olfr65 Olfr68 Ccr1 Prokr1 Agt Oprl1 Prokr2 Dagla Anxa1 Cxcr2 Ptafr Cxcr3 Nmur1 Nmur2 Olfr71 Cckar Cxcl3 Olfr76 Cxcl1 Pde8a Pde8b Olfr78 Pth Calca Ccl20 Ccr2 Cxcr6 Ccr5 Olfr1008 Olfr73 Cxcr4 Cxcl10 Cxcr5 Mgll Pde3a Apln Olfr1046 Olfr1047 Pde2a Olfr1173 Pth2 Olfr1034 Adm Gnat1 Gnat2 Gnat3 Olfr1044 Olfr1045 Pde4a Pde4b Olfr96 Hrh3 Olfr91 Olfr95 Pyy Hrh1 Hrh2 Hrh4 Olfr66 Hcar1 Cckbr Pde7a Aplnr Olfr90 Hcar2 Oprm1 Rgs17 Rgs18 Olfr705 Olfr583 Rgs14 Olfr980 Rgs19 Olfr982 Olfr1206 Olfr589 Olfr1209 Olfr309 Gnaz Rgs10 Rgs12 Rgs11 Qrfpr Olfr3 Olfr314 Olfr173 Rgs21 Rgs22 Olfr2 Rgs20 Rgs16 Olfr985 Rgs13 Olfr986 Olfr310 Olfr315 Olfr984 Olfr706 Olfr159 Olfr728 Olfr727 Olfr729 Olfr722 Olfr723 Olfr1414 Olfr720 Olfr1423 Olfr1425 Olfr1416 Olfr520 Olfr152 Gnal Gabbr2 Gabbr1 Olfr1408 Olfr160 Olfr305 Olfr165 Olfr164 Olfr1404 Olfr586 Olfr308 Olfr167 Olfr714 Olfr166 Olfr713 Olfr168 Olfr993 Olfr715 Olfr1204 Gm4461 Cysltr1 Adra1a Adra1b Penk Adra1d Grk6 Grk5 Mtnr1a Gpr176 Olfr1234 Mtnr1b Plcb1 Plcb2 Uts2 Hcrt Npsr1 Olfr790 Adra2a Olfr1211 Adra2c Adra2b Olfr1497 Olfr1496 Olfr1490 Olfr1494 Tacr2 Tacr3 Bdkrb1 Tacr1 Cysltr2 Bdkrb2 Kng2 Tshr Rgsl1 Olfr198 Gnrh1 Ppbp Olfr979 Olfr978 Olfr183 Olfr180 Olfr569 Olfr568 Olfr974 Olfr592 Olfr186 Olfr187 Insl5 Olfr1240 Plcb4 Plcb3 Olfr574 Olfr571 Pik3cg Insl3 Olfr577 Olfr578 Olfr576 Ppan Olfr196 Tshb Olfr193 Oxtr Olfr323 Olfr322 Olfr145 Olfr735 Olfr1426 Olfr1428 Ednra Ednrb Rln3 Rln1 Olfr1420 Olfr730 Olfr732 Olfr147 Olfr733 Olfr734 Olfr137 Olfr350 Olfr745 Olfr744 Prkcq Olfr357 Olfr749 Olfr351 Xcl1 Olfr558 Olfr557 Olfr556 Olfr554 Olfr1434 Olfr552 Prkch Olfr750 Olfr125 Arhgef11 Drd4 Olfr348 Arhgef12 Drd5 Drd2 Drd3 Drd1 Olfr354 Opn1mw Olfr355 Plxnb1 Tac2 Olfr1444 Olfr1445 Tac1 Gnrhr Rac2 Cga Lhb POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE%REACTOME DATABASE ID RELEASE 59%174411 Polymerase switching on the C-strand of the telomere Pold1 Pold2 Pold3 Pcna Pold4 Prim1 Rfc5 Rfc3 Rfc2 Pola1 Pola2 Rfc4 Prim2 Rfc1 CHEMOKINE RECEPTORS BIND CHEMOKINES%REACTOME DATABASE ID RELEASE 59%380108 Chemokine receptors bind chemokines Ccl5 Cxcr1 Ccr1 Ackr3 Pf4 Cxcr2 Cxcr3 Ccr9 Ccr8 Ccr7 Cxcl3 Ccr6 Cxcl1 Ccr4 Ccr3 Xcl1 Cxcl2 Ccl20 Cxcr6 Cxcl16 Ccr10 Ccr2 Cxcl13 Ccr5 Cxcr4 Cxcl10 Cxcr5 Cxcl9 Cxcl12 Cxcl5 Cxcl11 Cx3cl1 Ackr4 Ccl2 Xcr1 Ccl1 Ccl25 Ppbp Ccl28 Cx3cr1 Ccrl2 VEGF BINDS TO VEGFR LEADING TO RECEPTOR DIMERIZATION%REACTOME DATABASE ID RELEASE 59%195399 VEGF binds to VEGFR leading to receptor dimerization Vegfa Vegfb Vegfc Figf Kdr Flt4 Pgf Flt1 SCAVENGING BY CLASS F RECEPTORS%REACTOME DATABASE ID RELEASE 59%3000484 Scavenging by Class F Receptors Hyou1 Scarf1 Hsph1 Calr Hsp90aa1 Apob G2 M DNA REPLICATION CHECKPOINT%REACTOME DATABASE ID RELEASE 59%69478 G2 M DNA replication checkpoint Ccnb2 Wee1 Cdk1 Pkmyt1 THE IPAF INFLAMMASOME%REACTOME%R-HSA-844623.1 The IPAF inflammasome Casp1 Nlrc4 METABOLISM OF POLYAMINES%REACTOME DATABASE ID RELEASE 59%351202 Metabolism of polyamines Psmc6 Psmc5 Psmc2 Psmd2 Psmb9 Psmf1 Psmb8 Psme4 Psmc1 Psmc4 Psmc3 Psme3 Oaz3 Oaz2 Arg1 Paox Odc1 Srm Ckmt2 Ckmt1 Arg2 Gamt Ass1 Nags Oaz1 Nmral1 Slc6a8 Nqo1 Gatm Sat1 Agmat Azin2 Slc25a2 Azin1 Slc6a12 Cps1 Sms Otc Ckm Asl Ckb Slc6a7 Slc6a11 Slc25a15 Psmd12 Psma7 Psmd11 Psmd14 Psma5 Psmb5 Psmb4 Mri1 Psmd13 Psma4 Psmd10 Adi1 Psmb7 Got1 Psma3 Enoph1 Psma6 Apip Psmb6 Psmb2 Mtap Psmb3 Psmb1 Psma2 Psma1 Psmd9 Psmd1 Shfm1 Psme2 Psme1 Psmd3 Psmd4 Psmb10 Psmd6 Psmd5 Psmd7 Psmb11 Psmd8 AMINE COMPOUND SLC TRANSPORTERS%REACTOME%R-HSA-425428.1 Amine compound SLC transporters Slc6a11 Slc22a2 Rhag Slc22a1 Slc44a3 Slc44a4 Slc44a5 Rhcg Slc6a9 Slc5a7 Slc44a1 Slc6a5 Slc44a2 Slc6a6 Slc14a2 Slc18a1 Slc6a20a Slc14a1 Slc6a18 Slc6a19 Slc6a1 Slc6a2 Slc6a13 Slc6a15 Slc6a14 Rhbg Slc6a12 Slc18a2 Slc6a3 Slc6a7 SIGNALING BY FGFR2 FUSIONS%REACTOME DATABASE ID RELEASE 59%8853333 Signaling by FGFR2 fusions Fgfr2 SUMOYLATION OF DNA REPLICATION PROTEINS%REACTOME DATABASE ID RELEASE 59%4615885 SUMOylation of DNA replication proteins Birc5 Nup85 Nup160 Nup37 Incenp Nup50 Pias4 Pcna Nup43 Tpr Nup133 Pias3 Ndc1 Nup214 Top2b Aaas Nup210 Nup188 Nup54 Nup35 Nupl2 Nup62 Nup205 Nup155 Nup88 Pom121 Top1 Top2a Rae1 Nup93 Sumo3 Nup153 Aurkb Cdca8 Aurka Ranbp2 Nup107 Ube2i DEGRADATION OF GABA%REACTOME DATABASE ID RELEASE 59%916853 Degradation of GABA Abat Aldh5a1 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 59%68867 Assembly of the pre-replicative complex Psmc6 Psmc5 Psmc2 Psmd2 Psmb9 Psmb8 Psmf1 Psme4 Mcm6 Cdc6 Mcm3 Mcm2 Mcm5 Mcm4 E2f1 Psmc1 Psmc4 Psmc3 Psme3 Gmnn Orc4 Orc5 Mcm8 E2f2 Mcm7 Cdt1 E2f3 Orc2 Orc3 Orc6 Orc1 Psmd12 Psma7 Psmd11 Psmd14 Psma5 Psmb5 Psmb4 Psmd13 Ubc Psmd10 Psma4 Psmb7 Psma3 Psma6 Psmb6 Psmb2 Psmb3 Psmb1 Psma2 Psma1 Psmd9 Psmd1 Shfm1 Psme2 Psme1 Psmd3 Psmd4 Psmb10 Psmd6 Psmd5 Psmd7 Psmb11 Psmd8 ACTIVATION OF NA-PERMEABLE KAINATE RECEPTORS%REACTOME DATABASE ID RELEASE 59%451307 Activation of Na-permeable Kainate Receptors Grik1 Grik2 MICRORNA (MIRNA) BIOGENESIS%REACTOME%R-HSA-203927.2 MicroRNA (miRNA) biogenesis Polr2f Polr2i Polr2e Polr2j Ago2 Polr2h Ago1 Polr2c Polr2d Polr2b Ago4 Polr2g Polr2k Ago3 Polr2a Drosha Tarbp2 Ran Dgcr8 Xpo5 Prkra Dicer1 SEMET INCORPORATION INTO PROTEINS%REACTOME DATABASE ID RELEASE 59%2408517 SeMet incorporation into proteins Eprs Qars Kars Dars Rars Eef1e1 Lars Aimp1 Iars Mars Aimp2 IRS-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%R-HSA-2428928.1 IRS-related events triggered by IGF1R Pik3c3 Prkaa2 Akap9 Ppp2r1a Pik3r4 Prkaa1 Csf2 Jak1 Tsc1 Prkag2 Prkag1 Prkag3 Frs2 Nras Frs3 Rasgrf1 Psmf1 Raf1 Psme4 Il5ra Fgf1 Il17rd Fgf2 Cnksr1 Csk Cnksr2 Erbb2 Fgf9 Ptk2 Fgf7 Psme3 Fgf6 Fgf4 Fgf3 Ppp5c Ranbp9 Lamtor1 Ppp2cb Shc1 Lamtor2 Ppm1a Nrg2 Tlr9 Ppp2ca Igf1r Shc3 Lamtor5 Irs4 Nrg1 Igf2 Akt2 Igf1 Shc2 Psma7 Artn Nrtn Lamtor4 Brap Psmb5 Psmb4 Ubc Nrg3 Psmb7 Nrg4 Psmb6 Psmb2 Psmb3 Psmb1 Prkab1 Mapk3 Akt1 Mapk1 Ksr1 Ptpra Dusp16 Dusp10 Stk11 Map3k11 Prkab2 Paqr3 Psme2 Psme1 Ncam1 Sos1 Braf Psmb10 Apbb1ip Psmb11 Csf2rb2 Rapgef2 Csf2ra Actn2 Nf1 Tsc2 Pdgfrb Pdgfra Mlst8 Kbtbd7 Il2rg Arrb2 Egfr Gab1 Arrb1 Mtor Ret Vwf Rptor Sptan1 Pspn Pde3b Map2k1 Rbx1 Fgg Map2k2 Cul3 Rragd Psmd12 Rragb Pdgfb Rragc Psmd11 Rraga Rasgef1a Eif4b Psmd14 Rasa3 Rasa4 Psmd13 Psmd10 Il2 Rasa2 Rasa1 Nefl Spred3 Kit Spred2 Grin2a Spred1 Spta1 Il5 Sptbn4 Ppp2r1b Ywhab Kras Gdnf Shfm1 Cab39 Eif4e Strada Irs2 Stradb Cab39l Syngap1 Eef2k Hbegf Eif4g1 Irs1 Eif4ebp1 Il3ra Btc Il2ra Il2rb Angpt1 Ptpn11 Trib3 Psmc6 Egf Fgf23 Psmc5 Fgf22 Mark3 Psmc2 Fgf20 Psmd2 Dab2ip Tek Psmb9 Psmb8 Araf Hras Grin1 Ppp2r5e Dlg4 Ppp2r5c Ppp2r5d Ppp2r5a Psmc1 Psmc4 Psmc3 Pik3cb Sptbn2 Sptbn1 Itgb3 Fyn Phb Grin2c Rasgrp4 Rasgrp3 Pebp1 Ppp2r5b Rasgrp1 Tln1 Pik3ca Fga Fgb Grin2d Grin2b Sptb Hgf Gfra2 Gfra3 Gfra4 Ereg Jak2 Pea15a Itga2b Rap1a Jak3 Wdr83 Camk2d Rap1b Camk2a Fgfr4 Camk2b Psma5 Rasal3 Rasal2 Psma4 Psma3 Psma6 Akt1s1 Vcl Camk2g Psma2 Psma1 Gfra1 Psmd9 Dusp7 Iqgap1 Fgf16 Dusp6 Dusp9 Fgf15 Dusp8 Klb Fgf18 Them4 Psmd1 Met Fn1 Rasal1 Dusp1 Psmd3 Psmd4 Pdpk1 Psmd6 Psmd5 Dusp2 Psmd7 Pik3r1 Dusp5 Psmd8 Fgf10 Pik3r2 Dusp4 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION%REACTOME%R-HSA-69273.2 Cyclin A B1 associated events during G2 M transition Ppp2cb Ppp2r1b Wee1 Ccnb2 Mnat1 Ppp2ca Cdc25c Cdc25b Pkmyt1 Ppp2r1a Plk1 Xpo1 Ccnh Cdk1 Ppp2r2a Cdk2 Cdk7 Ccna1 Cdc25a Foxm1 Ccna2 DEFECTS IN COBALAMIN (B12) METABOLISM%REACTOME DATABASE ID RELEASE 59%3296469 Defects in cobalamin (B12) metabolism Amn Mut Mtrr Cd320 Cubn Mmadhc Mmaa Tcn2 Mtr Mmachc Gif IRF3-MEDIATED INDUCTION OF TYPE I IFN%REACTOME%R-HSA-3270619.1 IRF3-mediated induction of type I IFN Prkdc Tmem173 Xrcc5 Mre11a Tbk1 Ddx41 Xrcc6 Nlrp4e Nlrc3 Dtx4 Irf3 Trex1 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE DURING HIV INFECTION%REACTOME%R-HSA-167160.2 RNA Pol II CTD phosphorylation and interaction with CE during HIV infection Gtf2h5 Gtf2h4 Gtf2h3 Ercc3 Rngtt Rnmt Ercc2 Polr2i Polr2f Polr2j Polr2e Polr2h Polr2c Mnat1 Polr2d Polr2b Polr2k Polr2g Ccnh Polr2a Cdk7 Supt5 Gtf2f1 Gtf2h1 Gtf2f2 Gtf2h2 FORMATION OF APOPTOSOME%REACTOME DATABASE ID RELEASE 59%111458 Formation of apoptosome Casp9 Apaf1 GLUCOSE METABOLISM%REACTOME%R-HSA-70326.7 Glucose metabolism Hk1 Gapdhs Agl Ppp1r3c Phka1 Eno1b Slc25a10 Slc25a12 Ppp2r1a Prkacb Hk2 Pygm Hk3 Pck2 Pygl Gnpda2 Adpgk Ppp2r5d Gnpda1 Phkg2 Slc25a13 Slc25a11 Gaa Phka2 Epm2a Mdh1 Phkb Pygb Pgm1 Pck1 Prkaca Ppp2cb Ppp2ca Ubc Got1 Ppp2r1b Slc25a1 Aldoc Aldob Aldoa Pfkfb4 Gbe1 Pcx Gys2 Eno2 Eno3 Ugp2 Tpi1 Pgk2 Eno1 Pgk1 Pfkm Pfkp Mdh2 Pfkl Fbp1 Nhlrc1 Phkg1 Fbp2 Gpi1 Bpgm Pfkfb3 Pfkfb2 Gys1 Pgam1 Gyg Pgam2 Got2 Pgm2 Pfkfb1 Gck SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1)%REACTOME%R-HSA-381771.1 Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Grp Dpp4 Gcg Gnat3 Gng13 Sec11c Sec11a Cdx2 Gnb3 Lep Ffar4 Gpr119 Pcsk1 Spcs1 Tcf7l2 Spcs2 Spcs3 Ffar1 Pax6 TRANSPORT OF FATTY ACIDS%REACTOME DATABASE ID RELEASE 59%804914 Transport of fatty acids Apod Lcn9 Slc27a1 Slc27a6 Lcn12 Slc27a4 SYNTHESIS OF IPS IN THE NUCLEUS%REACTOME DATABASE ID RELEASE 59%1855191 Synthesis of IPs in the nucleus Ippk Ip6k1 Ip6k2 Ipmk NEGATIVE REGULATION OF THE PI3K AKT NETWORK%REACTOME%R-HSA-199418.3 Negative regulation of the PI3K AKT network Egf Fgf23 Fgf22 Fgf20 Frs2 Pdgfrb Ppp2r1a Pdgfra Vav1 Ppp2r5e Fgf1 Egfr Gab1 Ppp2r5c Fgf2 Ppp2r5d Ppp2r5a Erbb2 Phlpp1 Fgf9 Pik3cb Phlpp2 Fgf7 Pik3cd Fgf6 Fgf4 Fgf3 Fyn Ins2 Ppp2r5b Ier3 Pik3ca Hgf Cd86 Ppp2cb Pip5k1a Nrg2 Ereg Ppp2ca Nrg1 Akt2 Akt3 Pdgfb Cd80 Fgfr4 Nrg3 Nrg4 Kit Mapk3 Akt1 Pip5k1b Mapk1 Cd19 Pip5k1c Ppp2r1b Fgf16 Pip4k2b Pip4k2a Fgf15 Insr Pip4k2c Klb Fgf18 Pik3ap1 Them4 Met Trat1 Irs2 Lck Pten Hbegf Irs1 Pik3r3 Btc Pik3r1 Ptpn11 Fgf10 Pik3r2 Trib3 DNA REPLICATION%REACTOME DATABASE ID RELEASE 59%69306 DNA Replication Rb1 Rfc5 Mcm6 Gins1 Rfc3 Mcm3 Mcm2 Mcm5 Mcm4 Rfc2 Gins4 Rfc4 Gins2 Rfc1 Gins3 Orc4 Orc5 Mcm8 Mcm7 Pole Cdt1 Cdc45 Dna2 Pold1 Pold2 Pold3 Pold4 Orc2 Orc3 Orc6 Orc1 Prim1 Pole2 Rpa2 Rpa1 Rpa3 Pola1 Pola2 Lig1 Fen1 Pole4 Prim2 Pole3 Cdkn1a Psmd12 Psmd11 Psmd14 Psmd13 Psmd10 Shfm1 Psmc6 Psmc5 Psmc2 Psmd2 Pcna Psmb9 Psmb8 Psmf1 Psme4 Cdc6 Cdk2 E2f1 Psmc1 Ccna1 Psmc4 Psmc3 Ccna2 Psme3 Fzr1 Gmnn E2f2 E2f3 Cdkn1b Psma7 Psma5 Psmb5 Psmb4 Ubc Psma4 Psmb7 Psma3 Psma6 Psmb6 Psmb2 Cdc7 Psmb3 Psmb1 Psma2 Dbf4 Psma1 Mcm10 Psmd9 Psmd1 Psme2 Psme1 Psmd3 Psmd4 Psmb10 Psmd6 Psmd5 Psmd7 Psmb11 Psmd8 SYNTHESIS OF CL%REACTOME DATABASE ID RELEASE 59%1483076 Synthesis of CL Crls1 SIGNALING BY NGF%REACTOME%R-HSA-166520.2 Signaling by NGF Akap13 Ect2 Arhgef10l Sos2 Map2k5 Trio Ap2m1 Ap2a1 Ap2a2 Mcf2 Mcf2l Sh3gl2 Dnm2 Rps6ka5 Ap2s1 Dnm1 Arhgef7 Rps6ka3 Rps6ka2 Rps6ka1 Arhgef3 Arhgef4 Arhgef1 Arhgef2 Vav2 Clta Ap2b1 Arhgef9 Prex1 Cltc Dnm3 Itsn1 Csk Vrk3 Elk1 Mef2c Mef2a Dusp3 Mapk7 Adora2a Gna13 Adam17 Casp9 Prkcd Prkce Actn2 Nf1 Prkcg Tsc2 Pdgfrb Pdgfra Mlst8 Kbtbd7 Prkca Vav1 Il2rg Arrb2 Egfr Gab1 Arrb1 Mtor Ret Hdac1 Phlpp1 Ntrk1 Adrbk1 Ntrk2 Vwf Ralb Phlpp2 Rala Rtn4 Aph1b Omg Pspn Map2k1 Rbx1 Crkl Fgg Cdkn1a Map2k2 Cul3 Psmd12 Pdgfb Psmd11 Rasgef1a Psmd14 Rasa3 Rasa4 Psmd13 Psmd10 Il2 Rasa2 Rasa1 Nefl Spred3 Kit Spred2 Grin2a Spred1 Il5 Ppp2r1b Ywhab Ago2 Ago1 Tnrc6c Kras Insr Gsk3a Gsk3b Tnrc6b Gdnf Shfm1 Tnrc6a Ago4 Ago3 Itpr1 Trat1 Irs2 Mdm2 Lck Syngap1 Pten Hbegf Irs1 Il3ra Btc Il2ra Casp2 Il2rb Itpr3 Ptpn11 Angpt1 Itpr2 Trib3 Psmc6 Egf Adcyap1r1 Fgf23 Psmc5 Fgf22 Adcyap1 Mark3 Psmc2 Fgf20 Psmd2 Dab2ip Prkacb Tek Psmb9 Psmb8 Araf Hras Grin1 Prkar2b Ppp2r5e Mapkap1 Dlg4 Ppp2r5c Rps6kb2 Ppp2r5d Ppp2r5a Psmc1 Psmc4 Psmc3 Pik3cb Foxo3 Pik3cd Foxo1 Itgb3 Fyn Creb1 Phb Grin2c Rasgrp4 Rasgrp3 Pebp1 Camk4 Ngef Ppp2r5b Rasgrp1 Ier3 Tln1 Pik3ca Arhgef26 Fgd2 Net1 Fgd4 Cdkn1b Fgd1 Fga Fgd3 Fgb Grin2d Prkaca Arhgef17 Grin2b Arhgef10 Nr4a1 Vav3 Prr5 Hgf Plekhg5 Gfra2 Arhgef19 Gfra3 Pip5k1a Arhgef16 Arhgef15 Gfra4 Ereg Jak2 Abr Pea15a Arhgef18 Plekhg2 Itga2b Arhgef40 Rap1a Jak3 Wdr83 Camk2d Rap1b Camk2a Fgfr4 Camk2b Arhgef38 Psma5 Arhgef39 Rasal3 Rasal2 Psma4 Psma3 Psma6 Akt1s1 Arhgef37 Vcl Camk2g Psma2 Psma1 Gfra1 Pip5k1b Cd19 Pip5k1c Tiam2 Rit2 Psmd9 Tiam1 Ngf Dusp7 Aatf Iqgap1 Rit1 Fgf16 Ralgds Dusp6 Prdm4 Dusp9 Pcsk6 Fgf15 Mag Dusp8 Psen2 Klb Pcsk5 Fgf18 Kalrn Them4 Ncstn Sqstm1 Psmd1 Met Lingo1 Kidins220 Fn1 Bcl2l11 Ngfrap1 Rasal1 Dusp1 Psmd3 Psmd4 Pdpk1 Psmd6 Psmd5 Arhgdia Dusp2 Pik3r3 Psmd7 Crk Pik3r1 Dnal4 Dusp5 Smpd2 Psmd8 Maged1 Fgf10 Ngfr Pik3r2 Hdac3 Dusp4 Akap9 Ppp2r1a Ywhae Itgb3bp Nfkb1 Mapkapk3 Myd88 Hdac2 Irak1 Rac1 Mapk8 Ripk2 Rela Nfkbia Csf2 Prkci Cd86 Jak1 Cd80 Casp3 Stat3 Adcy7 Adcy6 Adcy5 Adcy4 Adcy3 Adcy2 Prkar2a Adcy1 Frs2 Nras Frs3 Rasgrf1 Adcy9 Psmf1 Adcy8 Raf1 Psme4 Il5ra Fgf1 Bad Il17rd Fgf2 Cnksr1 Cnksr2 Erbb2 Fgf9 Ptk2 Fgf7 Psme3 Fgf6 Fgf4 Fgf3 Furin Ppp5c Prkar1a Prkar1b Ranbp9 Ppp2cb Shc1 Lamtor2 Chuk Nrg2 Ppp2ca Shc3 Nrg1 Akt2 Akt3 Shc2 Psma7 Artn Nrtn Plcg1 Brap Psmb5 Psmb4 Ubc Nrg3 Psmb7 Nrg4 Psmb6 Psmb2 Psmb3 Psmb1 Mapk3 Akt1 Mapk1 Ksr1 Ptpra Dusp16 Dusp10 Map3k11 Pip4k2b Pip4k2a Trp53 Pip4k2c Paqr3 Pik3ap1 Pde1c Pde1b Psme2 Pde1a Psme1 Ncam1 Sos1 Rictor Braf Psmb10 Apbb1ip Ahcyl1 Rapgef1 Psmb11 Csf2rb2 Rapgef2 Csf2ra Mov10 Rhoa Mapkapk2 Ins2 Sptan1 Spta1 Sptbn4 Arhgef11 Arhgef12 Traf6 Ikbkb Sptbn2 Sptbn1 Sptb Mapk11 Mapk13 Mapk12 Mapk14 Arhgef6 MYD88 DEFICIENCY (TLR2 4)%REACTOME%R-HSA-5602498.1 MyD88 deficiency (TLR2 4) Cd36 Irak4 Tlr1 Tirap Tlr4 Myd88 Tlr2 Btk Tlr6 Ly96 Cd14 REGULATION OF PAK-2P34 ACTIVITY BY PS-GAP RHG10%REACTOME DATABASE ID RELEASE 59%211728 Regulation of PAK-2p34 activity by PS-GAP RHG10 Arhgap10 Pak2 RHO GTPASES ACTIVATE FORMINS%REACTOME%R-HSA-5663220.1 RHO GTPases Activate Formins Zw10 Dvl1 Ska1 Nup85 Pmf1 Nup160 Mkl1 Spc25 Dvl3 Actb Nudc Ppp2r1a Rps27 Spc24 Scai Xpo1 Clasp2 Itgb3bp Dvl2 Nuf2 Pfn2 Pfn1 Srf Rhoa Rhod Cenpf Ppp1cc Diap1 Cenpq Diap3 Cenpp Ahctf1 Rac1 Cenpm Cenpl Cenpo Clip1 Cenpn Aurkb Zwilch Cdca8 Cenpt Sec13 Apitd1 Sgol2b Ercc6l Dsn1 Nup107 Mad1l1 Cenph Cenpi Cenpe Cenpk Kif2c Taok1 Srgap2 Birc5 Kif2b Kif18a Actg1 Bub1b Zwint Nup37 Incenp Nup43 Daam1 Nup133 Rcc2 Nsl1 Kif2a Ndel1 Spdl1 Ndc80 Kntc1 Bub3 Bub1 Cenpu Mad2l1 Casc5 Cenpa Cenpc1 Ppp2r1b Cdc20 Sgol1 Ranbp2 Mis12 Pafah1b1 Itgb1 B9d2 Ppp2r5e Ppp2r5c Ppp2r5d Ppp2r5a Clasp1 Ppp2r5b Mapre1 Rhob Rhoc Ppp2cb Ckap5 Ppp2ca Plk1 Fmnl2 Fmnl3 Fmnl1 Evl NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS%REACTOME%R-HSA-418038.1 Nucleotide-like (purinergic) receptors P2ry1 P2ry2 P2ry13 Lpar4 P2ry12 P2ry14 P2ry10 Adora2b Adora2a Adora3 Adora1 Lpar6 Gpr17 Ppan P2ry6 P2ry4 TRIF-MEDIATED TLR3 TLR4 SIGNALING%REACTOME DATABASE ID RELEASE 59%937061 TRIF-mediated TLR3 TLR4 signaling Irf7 Tbk1 Ppp2r1a Irf3 Btrc Mapk9 Ikbke Nfkb2 Tank Nfkb1 Traf3 Fbxw11 Skp1a Saa3 Ppp2r5d Mapkapk3 Tnip2 Myd88 Nod2 Cul1 Nod1 Dhx9 Vrk3 S100b Elk1 Mef2c Mapk10 Mef2a Dusp3 Map3k7 Mapk7 Creb1 Mapkapk2 Irak2 Irak1 App Map2k6 Tab1 Tab2 Jun Mapk8 Tab3 Ripk2 Map2k7 Ager Map2k3 Map2k4 Map3k8 Rela Atf2 Nfkbia Nfkbib Fos Ppp2cb Casp8 Map2k1 Fadd Chuk Ppp2ca Ripk1 Ube2d3 Ubc Mapk3 Rps6ka5 Mapk1 Ppp2r1b Ticam2 Dusp7 Ube2d1 Ripk3 Birc3 Rps6ka3 Birc2 Dusp6 Rps6ka2 Ticam1 Rps6ka1 Traf6 Ikbkb Ube2v1 Tlr4 Ube2n Tlr3 Ly96 Cd14 Ikbkg Mapk11 Mapk14 Ptpn11 Dusp4 MMR%REACTOME DATABASE ID RELEASE 59%5358508 MMR Msh3 Msh6 Pold1 Pold2 Pold3 Pcna Pold4 Rsph10b Msh2 Rpa2 Rpa1 Rpa3 Mlh1 Lig1 Exo1 Pms2 THREONINE CATABOLISM%REACTOME%R-HSA-8849175.1 Threonine catabolism Gcat RELEASE OF HH-NP FROM THE SECRETING CELL%REACTOME DATABASE ID RELEASE 59%5362798 Release of Hh-Np from the secreting cell Disp2 Gpc5 Adam17 Ihh Shh Dhh Notum SELENOCYSTEINE SYNTHESIS%REACTOME%R-HSA-2408557.1 Selenocysteine synthesis Rpl39 Rplp1 Rpl7 Rps21 Rps27 Rplp2 Rps25 Rpl4 Sepsecs Rps26 Pstk Rps27l Eefsec Rpl18a Rpl34 Rpl32 Rpl26 Rpl24 Rps9 Secisbp2 Sars Rps7 Rps5 Rpl22 Rpl10l Rpl23 Rpl39l Rpl13a Rpl22l1 Rps15a Rpl11 Rpl17 Rps3 Rpl19 Rpl18 Rps16 Rps14 Rps19 Rps18 Rps11 Rps10 Rpsa Rpl37 Rps4x TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS%REACTOME DATABASE ID RELEASE 59%452723 Transcriptional regulation of pluripotent stem cells Stat3 Fgf2 Polr2i Polr2f Sall1 Pou5f1 Polr2j Polr2e Klf4 Polr2h Sall4 Polr2c Prdm14 Polr2d Foxd3 Zic3 Polr2b Epas1 Lin28a Smad4 Sox2 Smad2 Hif3a Epha1 Polr2k Zscan10 Polr2g Pbx1 Nr5a1 Polr2a PHOSPHOLIPASE C-MEDIATED CASCADE; FGFR4%REACTOME%R-HSA-5654228.2 Phospholipase C-mediated cascade; FGFR4 Fgf23 Fgf16 Fgf15 Fgf20 Klb Fgf18 Plcg1 Fgfr4 Fgf1 Fgf2 Fgf9 Fgf6 Fgf4 PYROPHOSPHATE HYDROLYSIS%REACTOME%R-HSA-71737.2 Pyrophosphate hydrolysis Ppa1 Ppa2 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD%REACTOME%R-HSA-3359473.1 Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD Mmadhc Mmachc DNA DOUBLE-STRAND BREAK REPAIR%REACTOME DATABASE ID RELEASE 59%5693532 DNA Double-Strand Break Repair Prkdc Xrcc5 Xrcc6 Trex1 Rfc5 Rfc3 Rfc2 Rfc4 Rfc1 Pole Nbn Atrip Dna2 Mapk8 Pold1 Pold2 Pold3 Bard1 Pold4 Chek2 Pole2 Rpa2 Rpa1 Mre11a Atm Hist2h2be Rpa3 Ube2i Rad17 Fen1 Pole4 Pole3 Hist1h2bg Hist1h2bh Hist1h2bp Rbbp8 Hist1h2bm Hist1h2bj Hist1h2bb Parp1 Rad1 Kat5 Ube2n Paxip1 Lig4 Ppp4c Smarca5 Tdp2 Tdp1 Lig3 Fam175a Kdm4a Polh Pias4 Pcna Apbb1 Kdm4b Clspn Poll Rnf168 Polk Eya3 Ube2v2 Dclre1c Eme1 Cdk2 Eya2 Eya1 Brcc3 Eya4 Rad50 Trp53bp1 Ccna1 Rad51b Baz1b Rad51c Uimc1 Gen1 Ccna2 Tipin Babam1 Ppp4r2 Rnf4 Ppp5c Hist3h2ba Rif1 Abl1 Polm Top3a Ercc4 Rtel1 Ercc1 Brca2 Polq Chek1 Topbp1 Rad9a Blm Ubc Rad9b Hus1 Mdc1 H2afx Exo1 Brip1 Rad52 Herc2 Rad51 Timeless Spidr Bre Rad51ap1 Trp53 Sirt6 Parp2 Slx4 Wrn Xrcc1 Mus81 Bap1 Whsc1 Hist1h3h Palb2 Brca1 Xrcc3 Rad51d Xrcc2 Xrcc4 SEMA4D IN SEMAPHORIN SIGNALING%REACTOME DATABASE ID RELEASE 59%400685 Sema4D in semaphorin signaling Myl6 Myh11 Erbb2 Rhoa Myh14 Myh10 Arhgap35 Limk1 Arhgef11 Limk2 Arhgef12 Rac1 Rras Plxnb1 Met Rnd1 Myl12b Myl12a Rac2 Sema4d Rhog Myh9 Rhob Rock1 Rhoc Rock2 TFAP2 (AP-2) FAMILY REGULATES TRANSCRIPTION OF OTHER TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 59%8866906 TFAP2 (AP-2) family regulates transcription of other transcription factors Tfap2a Cited2 Tfap2c Pitx2 CREATION OF C4 AND C2 ACTIVATORS%REACTOME%R-HSA-166786.2 Creation of C4 and C2 activators Crp C1rb Mbl2 C1s2 C1qc C1qb C1qa Fcnb PTK6 DOWN-REGULATION%REACTOME%R-HSA-8849472.1 PTK6 Down-Regulation Ptpn1 Srms Ptk6 PLUS-STRAND DNA SYNTHESIS%REACTOME%R-HSA-164525.1 Plus-strand DNA synthesis Ppia CAP-DEPENDENT TRANSLATION INITIATION%REACTOME%R-HSA-72737.2 Cap-dependent Translation Initiation Rpl39 Rplp1 Eif2s1 Eif2s2 Eif3i Eif3k Eif3l Eif3m Rpl7 Rps21 Rplp2 Rps27 Eif3a Eif3b Eif3c Rps25 Rpl4 Eif3d Rps26 Rps27l Eif3e Rpl18a Rpl34 Rpl32 Eif3f Eif3h Eif3g Rpl26 Rpl24 Rps9 Eif2s3x Rps7 Rps5 Rpsa Rpl37 Rps4x Eif4b Eif5 Eif5b Eif2b5 Eif2b4 Eif2b3 Eif2b2 Eif2b1 Eif4a1 Eif4a2 Rpl22 Eif1ax Rpl10l Rpl23 Rpl39l Eif3j2 Rpl13a Rpl22l1 Rps15a Rpl11 Rpl17 Rps3 Rpl19 Rpl18 Rps16 Eif4e Rps14 Rps19 Rps18 Eif4h Pabpc1 Rps11 Eif4g1 Rps10 Eif4ebp1 CARGO CONCENTRATION IN THE ER%REACTOME DATABASE ID RELEASE 59%5694530 Cargo concentration in the ER Lman2l Sar1b Stx5a Ctage5 Sec23a Gosr2 Tgfa Ctsz Mcfd2 Serpina1d Col7a1 Lman1l F5 Preb Areg Serpina1a F8 Sec24a Folr1 Sec24b Cnih1 Sec24d Gria1 Sec24c Cnih3 Ctsc Lman1 Cnih2 Sec22b Lman2 Cd59b DNA DAMAGE BYPASS%REACTOME%R-HSA-73893.1 DNA Damage Bypass Ube2b Poli Usp43 2810417H13Rik Rbx1 Ufd1l Vcp Ube2a Rchy1 Polh Rev1 Pcna Isg15 Ddb1 Dtl Zbtb32 Ube2l6 Polk Trim25 Rfc5 Rfc3 Ubc Rfc2 Rfc4 Rfc1 Pole Pold1 Pold2 Pold3 Pold4 Uba7 Mad2l2 Pole2 Cul4a Rpa2 Usp10 Rpa1 Rad18 Nploc4 Sprtn Usp1 Rpa3 Pole4 Cul4b Rev3l Pole3 TNFR2 NON-CANONICAL NF-KB PATHWAY%REACTOME DATABASE ID RELEASE 59%5668541 TNFR2 non-canonical NF-kB pathway Psmc6 Psmc5 Psmc2 Psmd2 Psmb9 Psmf1 Psmb8 Btrc Psme4 Nfkb2 Traf3 Fbxw11 Skp1a Psmc1 Psmc4 Psmc3 Cul1 Psme3 Tnfrsf1a Tnfrsf1b Edar Lta Ltb Tnf Chuk Uba3 Tnfrsf25 Fasl Tnfsf14 Tnfsf15 Ltbr Tnfsf12 Psmd12 Tnfsf13 Tnfsf18 Psma7 Psmd11 Map3k14 Cd70 Edaradd Tnfrsf8 Relb Psma5 Psmd14 Psmb5 Psmb4 Ubc Psmd13 Psma4 Psmd10 Psmb7 Psma3 Psma6 Psmb6 Tnfrsf11a Psmb2 Traf2 Tnfrsf11b Psmb3 Ube2m Psmb1 Psma2 Eda Psma1 Tnfsf8 Tnfsf4 Tnfsf11 Cd40lg Psmd9 Birc3 Birc2 Psmd1 Shfm1 Psme2 Psme1 Tnfrsf12a Psmd3 Tnfrsf4 Psmd4 Cd27 Psmb10 Eda2r Tnfrsf17 Psmd6 Tnfrsf14 Psmd5 Tnfsf13b Tnfrsf18 Psmd7 Tnfrsf13c Tnfrsf13b Psmb11 Tnfrsf9 Psmd8 TLR3 DEFICIENCY - HSE%REACTOME DATABASE ID RELEASE 59%5602410 TLR3 deficiency - HSE Tlr3 FORMATION OF INCISION COMPLEX IN GG-NER%REACTOME DATABASE ID RELEASE 59%5696395 Formation of Incision Complex in GG-NER Gtf2h5 Gtf2h4 Rbx1 Pias3 Ddb1 Gtf2h3 Ercc3 Ube2v2 Parp1 Ubc Cetn2 Rnf111 Ercc2 Ddb2 Mnat1 Sumo3 Parp2 Ube2n Chd1l Xpa Cul4a Ercc5 Rpa2 Pias1 Rpa1 Ccnh Rad23a Usp45 Rad23b Xpc Cdk7 Rpa3 Ube2i Ercc4 Gtf2h1 Ercc1 Cul4b Gtf2h2 SIGNALING BY ERBB4%REACTOME DATABASE ID RELEASE 59%1236394 Signaling by ERBB4 Shc1 Egf Esr1 Nrg2 Ereg Pgr Nrg1 Wwox Nras Yap1 Stat5a Hras Csn2 Egfr Ubc Itch Nrg3 Wwp1 Nrg4 Nedd4 Gfap S100b Aph1b Cxcl12 Ncor1 Tab2 Kras Psen2 Ncstn Pik3ca Sos1 Hbegf Btc Adam17 Pik3r1 METABOLISM OF VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 59%196854 Metabolism of vitamins and cofactors Mccc2 Agrn Mthfr Mccc1 Akr1c6 Btd Ldlr Tpk1 Lrp1 Slc52a3 Slc52a2 Slc23a1 Slc25a32 Shmt2 Bco1 Shmt1 Bco2 Slc23a2 Akr1c18 Apoa4 Cyp2r1 Nnmt Mthfsl Akr1c21 Apoa2 Apom Mthfd2 Fasn Mthfd1 Aldh1l2 Naprt Rdh11 Ppcs Rfk Pdzd11 Cyb5r3 Apoa1bp Pnlip Nampt Aldh1l1 Bst1 Nt5e Apoa1 Apob Clps Lgmn Hlcs Parp8 Slc5a8 Slc5a6 Coasy Apoc2 Apoc3 Vkorc1 Cyp27b1 Qprt Vkorc1l1 Ubiad1 Gpihbp1 Nmrk2 Thtpa Ptgis Ttr Lpl Acacb Slc46a1 Nmrk1 Mocos Ptgs2 Pcca Acaca Ctrb1 Mthfd2l Acp5 Pccb Prss2 Nadsyn1 Mmab Apoe Ctrc Cyb5a Rbp2 Cyp24a1 Rbp1 Folr2 Enpp3 Parp14 Pcx Akr1b10 Parp16 Rbp4 Enpp1 Cd38 Enpp2 Parp10 Mthfd1l Nmnat2 Nmnat1 Nmnat3 Abcc1 Gsto1 Gsto2 Gphn Aasdhppt Nudt12 Gc Ppcdc Vnn3 Lrp2 Plb1 Lrp12 Vnn1 Lrp10 Slc22a13 Dhfr Slc2a3 Slc2a1 Pdxk Pnpo Aox1 Nadk Slc19a2 Slc19a1 Slc25a19 Pank4 Mocs3 Mocs2 Lrat Pank1 Parp6 Pank3 Pank2 Parp9 Lmbrd1 Parp4 Flad1 Abcd4 Cyp8b1 Slc25a16 Sdc3 Sdc4 Gpc6 Sdc2 Gpc3 Sdc1 Gpc5 Gpc2 Gpc4 Mmachc Gif Amn Mut Mtrr Cd320 Cubn Mmadhc Mmaa Tcn2 Mtr Hspg2 Gpc1 CROSSLINKING OF COLLAGEN FIBRILS%REACTOME DATABASE ID RELEASE 59%2243919 Crosslinking of collagen fibrils Tll1 Loxl4 Loxl3 Pcolce Tll2 Loxl2 Loxl1 Lox Bmp1 HH MUTANTS ABROGATE LIGAND SECRETION%REACTOME%R-HSA-5387390.3 Hh mutants abrogate ligand secretion Psmc6 Psmc5 Psmc2 Vcp Os9 Psmd2 Derl2 Psmb9 Psmb8 Psmf1 Psme4 Syvn1 Sel1l Psmc1 Psmc4 Psmc3 Psme3 Ihh Shh Dhh Psmd12 Psma7 Psmd11 Psmd14 Psma5 Psmb5 Psmb4 Psmd13 Ubc Psmd10 Psma4 Psma3 Psmb7 Psma6 Psmb6 Psmb2 Psmb3 Psmb1 Psma2 Psma1 Psmd9 Psmd1 Shfm1 Psme2 Psme1 Psmd3 Psmd4 Psmb10 Psmd6 Psmd5 Psmd7 Psmb11 Psmd8 Erlec1 ACYL CHAIN REMODELLING OF PS%REACTOME%R-HSA-1482801.3 Acyl chain remodelling of PS Pla2g5 Pla2g4d Pla2g4e Pla1a Pla2g4f Pla2g2e Pla2g12a Osbpl8 Pla2g2d Pla2g1b Pla2g2f Osbpl5 Lpcat4 Lpcat3 Pla2g4a Pla2g10 Pla2r1 Pla2g16 Mboat1 Osbpl10 VITAMIN B5 (PANTOTHENATE) METABOLISM%REACTOME%R-HSA-199220.2 Vitamin B5 (pantothenate) metabolism Pdzd11 Pank4 Enpp3 Slc5a6 Coasy Pank1 Enpp1 Pank3 Pank2 Enpp2 Aasdhppt Ppcdc Vnn3 Fasn Vnn1 Slc25a16 Ppcs BILE SALT AND ORGANIC ANION SLC TRANSPORTERS%REACTOME%R-HSA-425471.1 Bile salt and organic anion SLC transporters Slc13a3 Emb Slc13a1 Slc13a2 Slc13a5 Slc16a3 Slc16a1 Bsg Slc13a4 Slc16a8 Slc10a6 Slc16a7 Slc47a1 HISTIDINE, LYSINE, PHENYLALANINE, TYROSINE, PROLINE AND TRYPTOPHAN CATABOLISM%REACTOME DATABASE ID RELEASE 59%6788656 Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism 2410127L17Rik Crym Qdpr Gstz1 Phykpl Aass Hal Il4i1 Hgd Aldh4a1 Ido2 Fah Ido1 Pipox Slc3a2 Kmo Tdo2 Hnmt Dld Afmid Ogdh Acmsd Hdc Asrgl1 Ftcd Prodh Uroc1 Slc7a5 Hpd Aldh7a1 Haao Carns1 Ccbl1 Pah Pcbd1 Hykk Tat Gcdh Kynu Amdhd1 Dlst Aadat Slc25a21 Ccbl2 UNFOLDED PROTEIN RESPONSE (UPR)%REACTOME DATABASE ID RELEASE 59%381119 Unfolded Protein Response (UPR) Ddit3 Nfyb Arfgap1 Herpud1 Eif2s1 Nfyc Parn Atf6 Igfbp1 Atf3 Atf4 Nfya Asns Edem1 Syvn1 Gosr2 Hsp90b1 Exosc9 Exosc8 Exosc7 Exosc5 Exosc4 Preb Ppp2r5b Tln1 Sec63 Ccl12 Klhdc3 Dcp2 Mbtps1 Mbtps2 Sec62 Dis3 Yif1a Lmna Exosc3 Zbtb17 Exosc1 Cul7 Exosc2 Serp1 Shc1 Sec61a2 Wipi1 Sec31a Ern1 Acadvl Calr Extl3 Eif2ak3 Tspyl2 Hdgf Sec61g Hspa5 Sec61a1 Gfpt1 Sec61b Asna1 Add1 Srprb Pdia6 Ssr1 Tpp1 Pdia5 Mydgf Wfs1 Atp6v0d1 Dnajb9 Dnajb11 Tatdn2 Cxxc1 Fkbp14 Ddx11 Srpr Dnajc3 Dctn1 Gsk3a Hyou1 Kdelr3 BETAKLOTHO-MEDIATED LIGAND BINDING%REACTOME%R-HSA-1307965.1 betaKlotho-mediated ligand binding Fgf15 Klb Fgfr4 SIGNALING BY TGF-BETA RECEPTOR COMPLEX%REACTOME DATABASE ID RELEASE 59%170834 Signaling by TGF-beta Receptor Complex Serpine1 Usp9x Cdk9 Cdk8 Ccnc Xpo1 Skil Sp1 Rbl1 E2f5 E2f4 Hdac1 Rhoa Atp1b4 Tgif2 Tgif1 Rnf111 Tfdp2 Tfdp1 Ppp1cc Ncor1 Smad4 F11r Smad2 Ncor2 Pard3 Smad7 Smad3 Furin Trim33 Ccnt1 Nedd4l Men1 Pard6a Ccnt2 Ppm1a Arhgef18 Ube2d3 Parp1 Ubc Ppp1cb Cbl Myc Wwtr1 Ube2m Cdkn2b Ski Ube2d1 Junb Tgfb1 Smurf1 Cgn Stub1 Prkcz Uchl5 Nedd8 Ppp1ca Strap Ppp1r15a Mtmr4 Tgfbr1 Pmepa1 Ccnk Fkbp1a Bambi Usp15 Tgfbr2 Smurf2 GENE EXPRESSION%REACTOME%R-HSA-74160.4 Gene Expression Serpine1 Hspa1a Med1 Csnk2a2 Hspa8 Cox14 Trim28 Parp1 Cox11 Ccng1 Zfp111 Vegfa Trp73 Med4 Cox16 Sco1 Med8 Med6 Zfp46 Zfp398 Cox18 Csnk2b Zfp708 Zfp707 Zfp706 Trp53rkb Zfp712 Zfp202 Helz2 Yeats4 Zfp141 Zfp212 Zfp418 Zfp710 Zfp558 Brpf3 Zfp819 Zfp711 Zfp551 Krba1 Ccne1 Mdm4 Brpf1 Ing5 Zfp867 Ccne2 Zfp213 Cox4i1 Hdac1 Ing2 Igfbp3 Nlrc4 Zfp566 Gls2 Maml2 Bid Hnf4a Polr2i Hnf4g Polr2j Maml1 Rptor Nelfa Zfp560 Nelfb Mnat1 Polr2c Map2k6 Polr2d Atrip Supt4a Zfp563 Polr2b Cnot11 Bcl2l14 Bard1 Zfp735 Zfp473 Zfp169 Polr2g Nr4a2 Cnot10 Chek2 Ctdp1 Zfp872 Nr5a1 Mre11a Zfp300 Zfp746 Zfp445 Zfp446 Polr2a Men1 Zfp740 Nelfe Zfp583 Supt5 Nelfcd Banp Gtf2f1 Kat2b Ncbp1 Kat2a Zfp180 Ncbp2 Cox8a Gtf2f2 Med20 mt-Co3 mt-Co2 E2f7 Cnot6l Med27 Med26 Tpx2 Plk3 Rragd Rragb Rragc Rraga Med23 Med24 Med25 Ercc3 Cox7b Plk2 Rad1 Setd8 Nrbp1 Chm Zfp426 Rxrg Tbx5 Zfp324 Fancd2 Havcr2 Apoe Zfp825 Ercc2 Ski Ube2d1 Hipk1 Notch4 Thrb Rxrb Junb Hipk2 Rxra Kat5 Gatad2a Carm1 Gatad2b Zfp839 Notch3 Thra Notch2 Zfp235 Zfp703 Cox5a Zfp157 Zfp334 Tmem55b Pou4f1 Pou4f2 Casp6 Zfp709 Casp1 Casp2 Zfp704 Meaf6 Tbl1xr1 Kctd1 Rara Rarb Trp53bp2 Pidd1 Nr2c1 Nr2c2 Zfp90 Kat6a Prdx2 Zfp84 Prdx1 Ywhag Ccnc Tead3 Hsp90aa1 Mapkapk5 Tead1 Tead2 Sp1 Zfp263 Bcl6 Zfp266 Cdk1 Zkscan1 Zkscan6 Zkscan8 Pin1 Atp1b4 Tgif2 Zfp369 Tgif1 Rnf111 Yy1 Tnks1bp1 Zfp51 Triap1 Smyd2 Esrrb Esrra Ell Esrrg Phf20 Trp63 Csnk1d Taf9b Zfp69 Zkscan4 Zkscan5 Csnk1e Cox6a1 Gls Zkscan3 Atf2 Trim33 Crebbp Zfp382 Gpx2 Zfp113 Zfp112 Apaf1 Fos Zfp37 Zfp248 Mlh1 Rgcc Rbpj Zfp30 Cox6b1 Cox20 Esr2 Zfp317 Zfp597 Chek1 Esr1 Zfp454 Ywhaz Cdc25c Atad2 Ywhah Tmem219 Sfn Btg2 Zfp750 Sgk1 Maml3 Zfp184 Rsph10b Cenpj Dyrk2 Zfp189 Zfp458 Mta2 Srprb Ube2d3 Blm Zfp1 Ssr1 Kdm5b Zfp2 Usp2 Hus1 Prmt5 Nr2c2ap Mdc1 Rarg Prmt1 Exo1 Brip1 Srpr Ndufa4 Pms2 Tfap2b Tfap2a Tigar Zik1 Nr2f1 Tfap2d Tfap2c Ak6 Tead4 Wrn Tfap2e Nr2f6 Zfp9 Gm28557 Jmy Brca1 Zfp287 Sesn2 Zfp286 Ccnh Sesn3 Ccnk Mamld1 Zfp282 Zfp78 Ncoa1 Surf1 Nr2e1 Zfp74 Ncoa6 Ncoa2 Runx2 Zkscan17 Perp Zkscan16 Zkscan14 Nuak1 Pgr Prkaa2 Ar Cdk9 Zscan25 Trp53inp1 Cdk8 Gata4 Skil Rffl Trex1 Rrm2b Taf1 Taf2 G6pdx Cdk12 Nr1h2 Ddit4 Cdk13 Rnf34 Prkaa1 Taf4b Taf7 Taf4a Taf5 Taf6 Taf3 Zfp13 Zfp14 Ddb2 Hdac2 Nbn Zfp11 Zfp12 Jun Smad4 Npm1 Smad2 Smad7 Slmo1 Taf9 Aurka Smad3 Ccnt1 Zfp28 Zfp27 Nedd4l Atm Nkx2-5 Rqcd1 Ep300 Fancc Fanci Kctd15 Ube2i Rad17 Ccnt2 Nr0b2 Txnrd1 Prelid1 Med31 Taf13 Sec61a2 Taf11 Nr1d1 Tbl1x Med30 Pml Arid3a Rbbp8 Nr1d2 Gadd45a Sec61g Tsc1 Sec61a1 Pitx2 Sec61b Rbbp7 Ctgf Lsm11 Lsm10 Taf12 Snrpb Snrpd3 Slbp Prkag2 Prkag1 Prkag3 Cnot4 Cnot7 Usp9x Cnot6 Cnot1 Cnot3 Brd7 Ppp1r13b Cnot2 Med13 Psmf1 Med14 Med12 Cnot8 Psme4 Msh2 Med10 Ppp1r13l Bax Chd9 Ndrg1 Med16 Med17 Erbb2 Rad50 Med15 Chd3 Chd4 Psme3 Bnip3l Rorc Ttc5 Zfp606 Zfp689 Rorb Zfp688 Rora Zfp605 Ncor1 Lrpprc Cradd Zfp697 Rabggta Ncor2 Zfp619 Mbd3 Zfp616 Rabggtb Zfp612 Hspd1 Steap3 Ssrp1 mt-Co1 Usp7 Zfp764 Zfp691 Zfp692 Lamtor1 Smarcd3 Top3a L3mbtl1 Gtf2h1 Ppard Zfp668 Gtf2h2 Zfp664 Ppp2cb Gtf2h5 Ppm1a Lamtor2 Gtf2h4 Txn1 Ppara Ppp2ca Lamtor5 Pparg Zfp661 Akt2 Wwox Akt3 Yap1 Psma7 Topbp1 Zfp667 Cox7a2l Lamtor4 Gtf2h3 Zfp777 Psmb5 Rad9a Psmb4 Aifm2 Ubc Zfp775 Rad9b Psmb7 Myc Pcbp4 Psmb6 Nop2 Psmb2 Cdkn2a Psmb3 Wwtr1 Psmb1 Prdm1 Prkab1 Cdkn2b Mapk3 Zfp385a Akt1 Zfp677 Dek Cited1 Cited2 Stk11 Zfp786 Pip4k2b Zfp770 Pip4k2a Zfp771 Prkab2 Trp53 Pip4k2c Tcea1 Tceb1 Zfp354a Zfp641 Tceb3 Psme2 Zfp647 Supt16 Psme1 Taco1 Cited4 Vdr Rictor Ehmt2 Nppa Psmb10 Zfp354b Rad51d Zfp799 Zfp354c Gpi1 Cdk7 Daxx Smurf2 Psmb11 Zfp791 Zfp790 Zfp658 Ehmt1 Mov10 Zfp655 Trdmt1 Gtf2a1 Mbd2 Cwc15 Igf2bp1 Ppie Gtf2a2 Ppih Gtf2b Rrp36 Nsun6 Elac2 Gtpbp3 Pdcd11 Asun Ppwd1 Tram1 Aars2 Nfix Krr1 Polr1a Qtrtd1 Polr1e Rars2 Upf3a Apeh Igf2bp3 Igf2bp2 Tyw1 Heatr1 Supt6 Mrm1 Zfp36 Yars2 Gtf2e1 Dcp1a Prcc Mapkapk2 Exosc9 Gtf2e2 Exosc8 Aars Exosc7 Mphosph10 Exosc5 Eef2 Exosc4 Nxt1 Ubtf Polr1b Diexf Pes1 Henmt1 Aff4 Asz1 Cirh1a Nop56 Tex10 Ptrf Cpsf3l Adar Dimt1 Tdrd9 Tdrd6 Dcp2 Nol9 Yars Nol6 Dis3 Xrn1 Utp3 Exosc3 Ipo8 Tnpo1 Vars Exosc1 Utp6 Exosc2 Nop58 Fas Lars2 Rpn2 Ell3 Xrn2 Ell2 Ccar1 Nfia Tnfrsf10b Nfic Mettl3 Ints10 Fars2 Mettl1 Ints12 Tdrd1 Eaf1 Taf8 Polrmt A1cf Ltv1 Trmt1 Rbm5 Tsen34 Nop10 Baz2a Farsa Snrpd2 Rprd1a Snrpd1 Farsb Rprd1b Rpn1 Nop14 Tsen15 Xpot Gspt1 Syf2 Trit1 Pdcd7 Gspt2 Fbl Snupn Rbmx Aqr Wdr3 Wdr4 Trmt5 Hars Sin3a Polr2f Polr2e Polr2h Tbp Gtf3c1 Gtf3c6 Gtf3c3 Gtf3c2 Bdp1 Gtf3c4 Polr2k Crcp Polr3a Polr3gl Polr3k Polr3h Brf1 Polr3f Polr3g Gtf3c5 Polr1d Polr1c Polr3d Polr3e Polr3b Gtf3a Polr3c Mapk11 Mapk14 Cwc22 Nhp2 Cwc27 Cwc25 Hnrnpd Hnrnpc Suv39h1 Trmt112 Nars Actb Gcfc2 Prpf4 Prpf3 Trmt10a Trmt10c Ercc6 Aebp2 Riok2 Rfc5 Wbp4 Riok1 Usp39 Rfc3 Nsun2 Hnrnpu Nsun4 Hnrnpr Hnrnpa2b1 Rfc2 Hnrnpl Hnrnpm Hnrnpf Zcrb1 Rfc4 Rngtt Riok3 Hnrnpk Rnmt H2afj Alkbh8 Lcmt2 H2afb2 Pelp1 Utp18 Qtrt1 Rtf1 Utp11l Utp15 Dna2 Anp32a Ice1 Rtcb N6amt1 Dhx16 Dhx15 Dcaf13 Wbscr22 Mterf1b Utp14a Mars2 Rpa2 Rnpc3 Rpa1 Plrg1 Prpf8 Hist2h2be Gpkow Sap30bp Prpf6 Rpa3 Zfp36l1 Cbx3 Hist2h2ac Smg8 Smg1 Smg6 H3f3b Smg7 H3f3a Smg9 Smg5 Hist1h2bg Isg20l2 Hist1h2bh Cars2 Gm10094 Paf1 Smndc1 Cd3eap Bms1 Srsf10 Hist1h2bp Ssb Hist1h2bm Prpf31 Adat2 Snrnp200 Hist1h2bj Adat1 Prpf19 Hist1h2bb Tars2 Wbp11 Ice2 Mphosph6 Zrsr2 Zc3h8 Utp20 Dhx37 Pop4 Pop1 Bop1 Ctnnbl1 Pop7 Pop5 Hnrnpul1 Sf1 Srp54a Txnl4a Hnrnph1 Apobec3 Apobec2 Apobec1 Rnmtl1 Hnrnph2 Nob1 Tbl3 Ssr2 Iws1 Ssr3 Ssr4 Hist1h3d Eef1b2 Eef1g Senp3 Eef1d U2surp Ddx1 Urm1 Hist1h2ak Eftud2 Fkbp6 Ddx5 Hist1h2ag Eef1a2 Ddx6 Mettl14 Mov10l1 Ddx4 Phf5a Jarid2 Apobec4 Hist1h2ah Sugp1 Emg1 Dkc1 Hbs1l Phf19 Etf1 Ddx52 Puf60 Rbm22 Tra2b Nup50 Ddx46 Noc4l Tpr Rbm17 Hnrnpa3 Las1l Ddx49 Ddx47 Dars2 Ndc1 Rprd2 Nup214 Smn1 Hist2h3c1 Sap30l Aaas Ddx42 Notch1 Nup210 Pan3 Nup188 Pan2 Nup54 Znrd1 Nup35 Srp72 Nupl2 C1d Nup62 Upf1 Nup205 Dcp1b Nup155 Ddost Trmu Nup88 Pom121 Trnt1 Upf2 Rae1 Srp68 Imp4 6430573F11Rik Sirt1 Edc4 Dnajc8 Nup93 Imp3 Rpap2 Nup153 Tfam Nol11 Isy1 Mllt1 Nt5c3b Prpf38a Mllt3 Piwil4 Arid4b Piwil1 Piwil2 Rrp8 Rrp9 Clns1a Srp14 Uhrf1 Ddx23 Mael Sap130 Drosha Ttf1 Tarbp2 Ran Hnrnpa1 Ddx20 Dgcr8 Hnrnpa0 Xpo5 Ddx21 Prkra Dicer1 Srp19 Trmt44 Sf3b4 Sf3b3 Sf3b2 Hspb1 Tprkb Eed Exosc10 Osgep Gemin5 Gemin4 Gemin7 Tfb1m Pqbp1 Sf3b6 Sf3b5 Crnkl1 Gemin2 Rpp14 Bcas2 Sf3a1 Sf3a2 Sf3b1 Sf3a3 Dars Taf1d Edc3 Rars Taf1c Eef1e1 Taf1b Lars Rcl1 Aimp1 Taf1a Iars Mars Gars Snrnp70 Aimp2 Gar1 Eprs Ybx1 Qars Cdkal1 Kars Rpp30 Rpp38 Vars2 Tfip11 Tfb2m AI597479 Snrnp27 Cherp Trmt61a Thg1l Hsd17b10 Snrnp25 Rpp40 Snrnp35 Snapc2 Snapc1 Snapc4 Elavl2 Skiv2l2 Elavl1 Snapc5 Mybbp1a Patl1 Pcbp1 Pcbp2 Snapc3 Cd2bp2 Snrnp48 Snrnp40 Suz12 Tars Fus Prkcd Bysl Ears2 Rpp21 Brf2 Rpp25 Tsc2 Phf1 Tsen54 Fam98b Tet3 Tet2 Tet1 Mlst8 Mterf4 Nars2 Prkca Pou2f1 Adarb1 Wars Prpf40a Egfr Skiv2l Zfp143 Mto1 Mtor Tsnax Trmt13 Trmt12 Trmt11 Pwp2 Sars2 Pno1 Ppil1 Pou2f2 Hars2 Ints6 Ints7 Tdrd12 2700060E02Rik Dcps Ints4 Ints5 Sap30 Phax Ints1 Ints3 Ints8 Suds3 Ints9 Wars2 Srrt Tyw3 Snrpn Srrm2 Snrpc Ints2 Tyw5 Snrpa Wdr61 Dnmt3a Mta1 Xab2 Eri1 Snrpa1 Mta3 Dus2 Lsm1 Lsm2 Dnmt3l Dnmt3b Lsm5 Lsm7 Lsm3 Cdkn1a Lsm4 Lsm8 Nxf7 Psmd12 Pus3 Lsm6 Psmd11 Ezh2 Ptbp1 Nxf1 Pus7 Sin3b Psmd14 Iars2 Ftsj1 Ftsj2 Psmd13 Snrpb2 Psmd10 Ttc37 Ppa1 Nabp1 Ppa2 Nabp2 Wdr75 Mtf2 Ctr9 Kit Sart1 Wdr77 Srp9 Sars Cdc73 Cdc5l Nat10 Ppp2r1b 1110008L16Rik Ywhab Dnmt1 Ago2 Pars2 Ago1 Ctu2 Ctu1 Tnrc6c Thumpd1 Tsr1 Tsen2 Tsr3 Gsk3b Rrn3 Tnrc6b Paip1 Zbtb8os Shfm1 Wdr12 Tnrc6a Tsn Ago4 Zmat5 Ago3 Tdrkh Wdr18 Wdr43 Vwa9 Mdm2 Mybl1 Wdr46 Pten Leo1 Cars Psmc6 Psmc5 Psmc2 Psmd2 Psmb9 Psmb8 Mapkap1 Ppp2r5c Psmc1 Psmc4 Psmc3 Sec11c Sec11a Cdkn1b Hist3h2ba Nr4a1 Spcs1 Prr5 Spcs2 Spcs3 Psma5 Psma4 Psma3 Psma6 H2afz Psma2 H2afx Psma1 Psmd9 Hist2h2aa1 Psmd1 Psmd3 Psmd4 Pdpk1 Psmd6 Psmd5 Psmd7 Psmd8 Nup85 Nup160 Ppp2r1a Rps27 Ywhae Xpo1 Dhx9 Aurkb Ppp2r2a Nup107 Birc5 Nup37 Tnfsf13 Nup43 Nup133 Ranbp2 Smarca5 Pcna Rbl2 Rbl1 Mybl2 Cdk2 E2f5 E2f4 E2f1 Ccna1 Baz1b Rbbp4 Ccna2 Tfdp2 Tfdp1 Eif5 Eif5b Eif2b5 Eif2b4 Eif2b3 Eif2b2 Eif2b1 Parn Tgfa Eif4b Cdk5r1 Eif4e Eif4g1 Eif4ebp1 Cdk5 Rpl39 Rplp1 Eif2s1 Eif2s2 Eif3i Eif3k Eif3l Eif3m Rpl7 Rps21 Rplp2 Eif3a Eif3b Eif3c Rps25 Rpl4 Cga Eif3d Rps26 Rps27l Eif3e Rpl18a Rpl34 Rpl32 Eif3f Eif3h Eif3g Rpl26 Rpl24 Rps9 Eif2s3x Rps7 Rps5 Pabpn1 Srsf2 Thoc7 Thoc6 Srsf3 Slu7 Srsf11 Zc3h11a Magoh Cpsf1 Cstf1 Dhx38 Clp1 Thoc3 Srsf7 Thoc2 Thoc5 Rpsa Thoc1 Srsf9 Rpl37 Alyref Rps4x Srsf6 Nudt21 Cstf2t Fip1l1 Rbm8a Cstf3 Casc3 Sympk Eif4a3 U2af1l4 Chtop Srsf1 Cstf2 Cpsf3 Cpsf2 Cpsf4 Cpsf7 Ddx39b Upf3b Ddx39 Papola Fyttd1 Wdr33 Rnps1 Poldip3 Magohb Cdc40 Srrm1 Eif4a1 Eif4a2 Rpl22 Eif1ax Rpl10l Rpl23 Rpl39l Eif3j2 Rpl13a Rpl22l1 Rps15a Rpl11 Rpl17 Rps3 Rpl19 Rpl18 Rps16 Rps14 Rps19 Rps18 Eif4h Pabpc1 Rps11 Rps10 RELEASE OF APOPTOTIC FACTORS FROM THE MITOCHONDRIA%REACTOME DATABASE ID RELEASE 59%111457 Release of apoptotic factors from the mitochondria Diablo PRESYNAPTIC FUNCTION OF KAINATE RECEPTORS%REACTOME DATABASE ID RELEASE 59%500657 Presynaptic function of Kainate receptors Gngt1 Gng7 Gng4 Gngt2 Gng10 Plcb1 Plcb2 Gng11 Gng13 Gng12 Gnb2 Plcb3 Gnb1 Gnb3 Gnb5 Gnb4 Grik3 Gng8 Gng3 Gng2 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS%REACTOME DATABASE ID RELEASE 59%264870 Caspase-mediated cleavage of cytoskeletal proteins Add1 Casp3 Plec Casp8 Casp7 Casp6 Gas2 Vim Dbnl Sptan1 Gsn B CELL ACTIVATION%REACTOME DATABASE ID RELEASE 59%983705 B Cell Activation Ppp2r1a Prkcb Btrc Nfkb1 Fbxw11 Map3k7 Rela Nfkbia Nfkbib Cd86 Cd80 Frs2 Nras Psmf1 Psme4 Fgf1 Bad Skp1a Fgf2 Erbb2 Fgf9 Fgf7 Cul1 Psme3 Fgf6 Fgf4 Fgf3 Ppp2cb Chuk Srms Nrg2 Ppp2ca Nrg1 Akt2 Akt3 Psma7 Plcg1 Psmb5 Psmb4 Ubc Nrg3 Psmb7 Nrg4 Psmb6 Psmb2 Psmb3 Psmb1 Nck1 Mapk3 Akt1 Mapk1 Pip4k2b Pip4k2a Trp53 Pip4k2c Pik3ap1 Psme2 Psme1 Sos1 Rictor Psmb10 Ahcyl1 Psmb11 Mov10 Casp9 Tsc2 Pdgfrb Pdgfra Mlst8 Vav1 Egfr Gab1 Mtor Phlpp1 Phlpp2 Ins2 Cdkn1a Psmd12 Pdgfb Psmd11 Psmd14 Lyn Psmd13 Psmd10 Cbl Kit Ppp2r1b Ago2 Ago1 Tnrc6c Kras Insr Ikbkb Gsk3a Gsk3b Tnrc6b Shfm1 Tnrc6a Ago4 Ikbkg Ago3 Itpr1 Trat1 Irs2 Mdm2 Lck Pten Hbegf Irs1 Ptpn6 Btc Itpr3 Ptpn11 Itpr2 Trib3 Psmc6 Egf Fgf23 Psmc5 Fgf22 Psmc2 Fgf20 Psmd2 Psmb9 Psmb8 Hras Cd79b Ppp2r5e Malt1 Mapkap1 Card11 Cd79a Ppp2r5c Rps6kb2 Ppp2r5d Ppp2r5a Psmc1 Psmc4 Psmc3 Pik3cb Foxo3 Pik3cd Foxo1 Stim1 Fyn Creb1 Cd22 Trpc1 Orai1 Orai2 Dapp1 Rasgrp3 Plcg2 Blk Bcl10 Blnk Ppp2r5b Cblb Rasgrp1 Syk Ier3 Sh3kbp1 Rel Pik3ca Nfkbie Cdkn1b Nr4a1 Prr5 Hgf Pip5k1a Ereg Btk Fgfr4 Psma5 Psma4 Psma3 Psma6 Akt1s1 Psma2 Psma1 Pip5k1b Cd19 Pip5k1c Psmd9 Fgf16 Fgf15 Klb Fgf18 Them4 Psmd1 Met Psmd3 Psmd4 Pdpk1 Psmd6 Psmd5 Pik3r3 Psmd7 Pik3r1 Psmd8 Fgf10 Pik3r2 E2F-ENABLED INHIBITION OF PRE-REPLICATION COMPLEX FORMATION%REACTOME%R-HSA-113507.2 E2F-enabled inhibition of pre-replication complex formation Orc4 Orc5 Mcm8 Cdk1 Cdc25a Orc2 Orc3 Orc6 Orc1 INFLUENZA VIRUS INDUCED APOPTOSIS%REACTOME%R-HSA-168277.3 Influenza Virus Induced Apoptosis Tgfb1 Slc25a5 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE%REACTOME%R-HSA-71406.1 Pyruvate metabolism and Citric Acid (TCA) cycle Ldhc Pdhb Dlat Adhfe1 Pdpr Glo1 Ldha Ldhb Pdp2 Pdp1 Pdhx Pdha1 D2hgdh Ldhal6b L2hgdh Pdk1 Pdk2 Mpc1 Mpc2 Pdk3 Pdk4 Rxra Dld Ogdh Idh3g Sdhd Sdha Mdh2 Sdhc Suclg2 Suclg1 Sdhb Idh2 Slc16a3 Idh3b Slc16a1 Idh3a Bsg Fh1 Sucla2 Slc16a8 Nnt Ppard Dlst Aco2 Cs A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD%REACTOME%R-HSA-157212.2 A third proteolytic cleavage releases NICD Notch4 Notch1 Psen2 Ncstn Notch3 Aph1b Notch2 PHASE 4 - RESTING MEMBRANE POTENTIAL%REACTOME DATABASE ID RELEASE 59%5576886 Phase 4 - resting membrane potential Kcnk1 Kcnk12 Kcnj2 Kcnk15 Kcnj12 Kcnk9 Kcnj4 Kcnk7 Kcnk6 Kcnk5 Kcnk2 Kcnk13 Kcnk3 Kcnk10 Kcnk4 Kcnk18 Kcnk16 Kcnj14 INTEGRATION OF VIRAL DNA INTO HOST GENOMIC DNA%REACTOME%R-HSA-175567.1 Integration of viral DNA into host genomic DNA Psip1 Banf1 Hmga1 INTERACTION WITH THE ZONA PELLUCIDA%REACTOME%R-HSA-1300644.1 Interaction With The Zona Pellucida Zp3 B4galt1 Adam2 Ovgp1 Adam30 Adam21 Zp1 Zp2 ANCHORING FIBRIL FORMATION%REACTOME DATABASE ID RELEASE 59%2214320 Anchoring fibril formation Tll1 Tll2 Col7a1 Lamb3 Lama3 Bmp1 Lamc2 MET PROMOTES CELL MOTILITY%REACTOME%R-HSA-8875878.1 MET promotes cell motility Lamc1 Itgb1 Crkl Rap1a Rap1b Dock7 Gab1 Lamb1 Ptk2 Lama5 Lama2 Lama4 Rac1 Itga3 Lamb3 Src Lama1 Tns4 Lamc3 Lamb2 Tns3 Met Lama3 Itga2 Crk Rapgef1 Hgf Lamc2 ACYL CHAIN REMODELING OF CL%REACTOME DATABASE ID RELEASE 59%1482798 Acyl chain remodeling of CL Hadhb Lclat1 Hadha Pla2g4a Pla2g6 Taz DOWNSTREAM SIGNAL TRANSDUCTION%REACTOME%R-HSA-186763.1 Downstream signal transduction Akap9 Ppp2r1a Csf2 Cd86 Jak1 Cd80 Stat3 Adcy7 Adcy6 Adcy5 Adcy4 Adcy3 Adcy2 Prkar2a Adcy1 Frs2 Nras Frs3 Rasgrf1 Adcy9 Psmf1 Adcy8 Raf1 Psme4 Il5ra Fgf1 Bad Il17rd Fgf2 Cnksr1 Csk Cnksr2 Erbb2 Fgf9 Ptk2 Fgf7 Psme3 Fgf6 Fgf4 Fgf3 Ppp5c Prkar1a Prkar1b Ranbp9 Ppp2cb Shc1 Lamtor2 Chuk Nrg2 Ppp2ca Shc3 Nrg1 Akt2 Akt3 Shc2 Psma7 Artn Nrtn Plcg1 Brap Nck2 Psmb5 Psmb4 Ubc Nrg3 Psmb7 Nrg4 Psmb6 Psmb2 Psmb3 Psmb1 Nck1 Mapk3 Akt1 Mapk1 Ksr1 Ptpra Dusp16 Dusp10 Map3k11 Pip4k2b Pip4k2a Trp53 Pip4k2c Paqr3 Pik3ap1 Pde1c Pde1b Psme2 Pde1a Psme1 Ncam1 Sos1 Rictor Braf Psmb10 Apbb1ip Ahcyl1 Rapgef1 Psmb11 Csf2rb2 Rapgef2 Csf2ra Mov10 Grb7 Casp9 Prkcd Prkce Actn2 Nf1 Prkcg Tsc2 Pdgfrb Stat5b Pdgfra Stat5a Mlst8 Kbtbd7 Prkca Vav1 Il2rg Arrb2 Egfr Gab1 Arrb1 Mtor Ret Phlpp1 Adrbk1 Vwf Phlpp2 Ins2 Sptan1 Pspn Map2k1 Rbx1 Crkl Fgg Cdkn1a Map2k2 Cul3 Psmd12 Pdgfb Psmd11 Rasgef1a Psmd14 Rasa3 Rasa4 Psmd13 Psmd10 Il2 Rasa2 Rasa1 Nefl Spred3 Kit Spred2 Grin2a Spred1 Spta1 Il5 Sptbn4 Ppp2r1b Ywhab Ago2 Ago1 Tnrc6c Kras Insr Gsk3a Gsk3b Tnrc6b Gdnf Shfm1 Tnrc6a Ago4 Ago3 Itpr1 Trat1 Irs2 Mdm2 Lck Syngap1 Pten Hbegf Irs1 Il3ra Btc Il2ra Il2rb Itpr3 Ptpn11 Angpt1 Itpr2 Trib3 Psmc6 Egf Fgf23 Psmc5 Fgf22 Mark3 Psmc2 Fgf20 Psmd2 Dab2ip Prkacb Tek Psmb9 Psmb8 Araf Hras Grin1 Prkar2b Ppp2r5e Mapkap1 Dlg4 Ppp2r5c Rps6kb2 Ppp2r5d Ppp2r5a Psmc1 Psmc4 Psmc3 Pik3cb Foxo3 Sptbn2 Pik3cd Foxo1 Sptbn1 Itgb3 Fyn Creb1 Phb Grin2c Stat1 Rasgrp4 Rasgrp3 Stat6 Pebp1 Camk4 Ppp2r5b Rasgrp1 Ier3 Tln1 Pik3ca Cdkn1b Fga Fgb Grin2d Prkaca Grin2b Nr4a1 Sptb Prr5 Hgf Gfra2 Gfra3 Pip5k1a Gfra4 Ereg Jak2 Pea15a Itga2b Rap1a Jak3 Wdr83 Camk2d Rap1b Camk2a Fgfr4 Camk2b Psma5 Rasal3 Rasal2 Psma4 Psma3 Psma6 Akt1s1 Vcl Camk2g Psma2 Psma1 Gfra1 Pip5k1b Cd19 Pip5k1c Psmd9 Dusp7 Iqgap1 Fgf16 Dusp6 Dusp9 Fgf15 Dusp8 Klb Fgf18 Them4 Psmd1 Met Fn1 Bcar1 Rasal1 Dusp1 Psmd3 Psmd4 Pdpk1 Psmd6 Psmd5 Dusp2 Pik3r3 Psmd7 Crk Pik3r1 Dusp5 Psmd8 Fgf10 Pik3r2 Dusp4 CONJUGATION OF SALICYLATE WITH GLYCINE%REACTOME DATABASE ID RELEASE 59%177128 Conjugation of salicylate with glycine Acsm2 Glyatl3 Glyat Acsm5 Acsm4 G BETA:GAMMA SIGNALLING THROUGH PLC BETA%REACTOME DATABASE ID RELEASE 59%418217 G beta:gamma signalling through PLC beta Gngt1 Gng7 Gng4 Gngt2 Gng10 Plcb1 Plcb2 Gng11 Gng13 Gng12 Gnb2 Plcb3 Gnb1 Gnb3 Gnb5 Gnb4 Gng8 Gng3 Gng2 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION%REACTOME%R-HSA-2565942.1 Regulation of PLK1 Activity at G2 M Transition Pafah1b1 Ccp110 Nek2 Cep57 Akap9 Haus7 Haus8 Ppp2r1a Ywhag Ywhae Hsp90aa1 Ninl Ywhaq Cep152 Rab8a Btrc Prkar2b Haus3 Ppp1r12a Haus4 Cdk1 Fbxw11 Skp1a Cetn2 Ofd1 Haus2 Cul1 Cep63 Alms1 Haus5 Haus6 Haus1 Tubb4a Optn Tubb4b Ccnb2 Clasp1 Ssna1 Tubg1 Csnk1d Cep250 Tuba4a Dynll1 Csnk1e Cep135 Aurka Cdk5rap2 Mapre1 Pcnt Sfi1 Cep70 Nedd1 Actr1a Cep131 Pcm1 Prkaca Dync1i2 Ajuba Fgfr1op Cep76 Cep78 Cep72 Bora Dctn2 Dctn3 Ckap5 Cep164 Tubb5 Tuba1a Cep41 Plk1 Cenpj Dync1h1 Plk4 Sdccag8 Ubc Ppp1cb PLC-MEDIATED HYDROLYSIS OF PIP2%REACTOME DATABASE ID RELEASE 59%139943 PLC-mediated hydrolysis of PIP2 Pdpn Clec1b Plcg2 Syk G2 M TRANSITION%REACTOME DATABASE ID RELEASE 59%69275 G2 M Transition Akap9 Ppp2r1a Ywhae Xpo1 Ninl Cep152 Btrc Lin37 Fbxw11 Lin54 Cenpf Mnat1 Aurka Ppp2r2a Ep300 Rbx1 Cdkn1a Tpx2 Psmd12 Psmd11 Psmd14 Psmd13 Psmd10 Ppp2r1b Shfm1 Hsp90ab1 Pafah1b1 Psmc6 Psmc5 Ccp110 Nek2 Cep57 Psmc2 Psmd2 Haus7 Haus8 Ywhag Lin9 Psmb9 Hsp90aa1 Psmf1 Psmb8 Ywhaq Rab8a Psme4 Prkar2b Mybl2 Haus3 Ppp1r12a Haus4 Cdk2 Cdk1 Skp1a Cetn2 Ccna1 Psmc1 Ofd1 Psmc4 Rbbp4 Haus2 Cdc25a Psmc3 Cep63 Cul1 Ccna2 Alms1 Psme3 Haus5 Lin52 Haus6 Haus1 Tubg2 Tubb4a Optn Tubb4b Numa1 Ccnb2 Phlda1 Clasp1 Gtse1 Ssna1 Cdc25b Tubg1 Pkmyt1 Csnk1d Cep250 Tuba4a Dynll1 Cdk11b Csnk1e Tubgcp5 Cep135 Tubgcp4 Tubgcp3 Cdk5rap2 Mapre1 Pcnt Sfi1 Cep70 Nedd1 Actr1a Cep131 Pcm1 Tubgcp2 Prkaca Hmmr Dync1i2 Ajuba Fgfr1op Foxm1 Fbxl7 Cep76 Fkbpl Cep78 Cep72 Fbxl18 Bora Dctn2 Ppp2cb Dctn3 Wee1 Ckap5 Cep164 Ppp2ca Cdc25c Tubb5 Tuba1a Cep41 Plk1 Psma7 Cenpj Dync1h1 Psma5 Plk4 Psmb5 Sdccag8 Psmb4 Ubc Psma4 Ppp1cb Psma3 Psmb7 Psma6 Psmb6 Psmb2 Psmb3 Psma2 Psmb1 Psma1 Psmd9 Trp53 Psmd1 Psme2 Psme1 Psmd3 Psmd4 Psmb10 Ccnh Psmd6 Psmd5 Cdk7 Psmd7 Psmb11 Psmd8 ELECTRIC TRANSMISSION ACROSS GAP JUNCTIONS%REACTOME DATABASE ID RELEASE 59%112303 Electric Transmission Across Gap Junctions Gja10 Gjc1 Panx1 Panx2 Gjd2 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS)%REACTOME%R-HSA-70221.1 Glycogen breakdown (glycogenolysis) Pgm1 Agl Phka1 Pygm Pygl Phkg1 Phkg2 Gyg Gaa Phka2 Pgm2 Phkb Pygb INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION%REACTOME%R-HSA-168273.2 Influenza Viral RNA Transcription and Replication Rpl39 Rplp1 Nup85 Nup160 Nup50 Rpl7 Rps21 Rplp2 Rps27 Tpr Hsp90aa1 Rps25 Rpl4 Ndc1 Rps26 Nup214 Rps27l Aaas Rpl18a Nup210 Rpl34 Nup188 Rpl32 Nup54 Nup35 Nupl2 Nup62 Nup205 Rpl26 Rpl24 Nup155 Nup88 Rps9 Pom121 Rps7 Rae1 Rps5 Polr2i Polr2f Polr2j Polr2e Polr2h Nup93 Polr2c Polr2d Polr2b Nup153 Polr2g Polr2k Nup107 Polr2a Rpsa Gtf2f1 Rpl37 Rps4x Gtf2f2 Nup37 Nup43 Nup133 Dnajc3 Rpl22 Rpl10l Rpl23 Rpl39l Rpl13a Rpl22l1 Rps15a Rpl11 Rpl17 Rps3 Rpl19 Rpl18 Rps16 Ipo5 Rps14 Grsf1 Rps19 Rps18 Ranbp2 Rps11 Rps10 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX%REACTOME%R-HSA-195253.1 Degradation of beta-catenin by the destruction complex Psmc6 Psmc5 Psmc2 Psmd2 Ppp2r1a Psmb9 Psmf1 Psmb8 Btrc Psme4 Ppp2r5e Ppp2r5c Skp1a Ppp2r5d Hdac1 Ppp2r5a Psmc1 Psmc4 Psmc3 Cul1 Psme3 Ppp2r5b Ppp2cb Apc Rbx1 Axin1 Ppp2ca Amer1 Csnk1a1 Ctnnb1 Psmd12 Psma7 Psmd11 Psmd14 Psma5 Psmb5 Psmb4 Ubc Psmd13 Psmd10 Psma4 Psmb7 Psma3 Psma6 Psmb6 Psmb2 Psmb3 Psmb1 Psma2 Psma1 Ppp2r1b Ctbp1 Psmd9 Frat2 Tcf7l1 Tle3 Ctbp2 Aes Lef1 Tcf7 Gsk3b Psmd1 Shfm1 Tle1 Psme2 Tle4 Psme1 Tle2 Psmd3 Psmd4 Psmb10 Psmd6 Psmd5 Psmd7 Psmb11 Psmd8 Tcf7l2 CHROMOSOME MAINTENANCE%REACTOME%R-HSA-73886.1 Chromosome Maintenance Dkc1 Nhp2 Smarca5 Pcna Itgb3bp Rfc5 Rfc3 Rfc2 Rbbp4 Rfc4 H2afj Rfc1 H2afb2 Cenpq Cenpp Pole Cenpm Cenpl Dna2 Pold1 Cenpo Pold2 Npm1 Pold3 Cenpn Pold4 Cenpt Apitd1 Prim1 Pole2 Rpa2 Rpa1 Hist2h2be Hist3h2ba Rpa3 Pola1 Hist2h2ac Pola2 Lig1 Fen1 Cenph Cenpi Pole4 Prim2 Cenpk Pole3 Tinf2 Hist1h2bg Hist1h2bh Pot1a Wrap53 Tert Mis18bp1 Cenpw Terf1 Terf2 Hist1h2bp Acd Hist1h2bm Ruvbl2 Ruvbl1 Stra13 Hist1h2bj Mis18a Oip5 Hist1h2bb Rbbp7 Rsf1 Cenpu H2afz Casc5 Terf2ip H2afx Cenpa Cenpc1 Hist2h2aa1 Hist1h3h Hist1h2ak Hist1h2ag Hist1h2ah ACTIVATION OF BMF AND TRANSLOCATION TO MITOCHONDRIA%REACTOME DATABASE ID RELEASE 59%139910 Activation of BMF and translocation to mitochondria Dynll2 Mapk8 Bmf NECTIN NECL TRANS HETERODIMERIZATION%REACTOME%R-HSA-420597.2 Nectin Necl trans heterodimerization Cadm3 Pvrl4 Cadm1 Pvrl1 Pvrl2 Pvrl3 LYSINE CATABOLISM%REACTOME%R-HSA-71064.2 Lysine catabolism Crym Aldh7a1 Phykpl Aass Hykk Dld Ogdh Gcdh Dlst Pipox Aadat Slc25a21 MITOCHONDRIAL UNCOUPLING PROTEINS%REACTOME DATABASE ID RELEASE 59%166187 Mitochondrial Uncoupling Proteins Slc25a27 Slc25a14 Ucp1 Ucp3 Ucp2 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24-HYDROXYCHOLESTEROL%REACTOME%R-HSA-193775.1 Synthesis of bile acids and bile salts via 24-hydroxycholesterol Akr1c6 Ptgis Slc27a5 Cyp46a1 Akr1c18 Cyp27a1 Akr1d1 Amacr Hsd3b7 Akr1c21 Cyp39a1 Cyp8b1 Slc27a2 TOXICITY OF BOTULINUM TOXIN TYPE D (BONT D)%REACTOME DATABASE ID RELEASE 59%5250955 Toxicity of botulinum toxin type D (BoNT D) Sv2c Vamp1 Sv2b Sv2a Vamp2 TWIK RELATED POTASSIUM CHANNEL (TREK)%REACTOME DATABASE ID RELEASE 59%1299503 TWIK related potassium channel (TREK) Kcnk2 Kcnk10 Kcnk4 PHOSPHOLIPID METABOLISM%REACTOME DATABASE ID RELEASE 59%1483257 Phospholipid metabolism Pik3c3 Pik3r4 Lclat1 Crls1 Pla2g6 Taz Hadhb Hadha Ocrl Mfsd2a Dgat2 Chkb Gde1 Pi4kb Pld3 Csnk2a2 Etnppl Bmx Rab5a Cept1 Dgat2l6 Mtmr2 Chat Mtmr1 Dgat1 Chka Mtmr3 Tnfaip8l2 Mtmr7 Mtmr6 Tnfaip8 Inppl1 Tnfaip8l1 Gnpat Tnfaip8l3 Inpp5k Pgs1 Pitpnm1 Abhd4 Vac14 Pcyt2 Slc44a3 Abhd3 Mgll Slc44a4 Lpcat1 Slc44a5 Slc44a1 Slc44a2 Csnk2b Plekha5 Plekha6 Lpgat1 Aldh7a1 Plekha8 Bhmt Pten Synj2 Tmem55b Plekha1 Plekha2 Pld2 Pi4ka Pld1 Gpd1l Plb1 Synj1 Pld4 Gpcpd1 Plekha3 Cpne3 Acp6 Pemt Cpne1 Pla2g5 Pla2g4d Gpd1 Pla2g4e Pi4k2b Pla1a Cpne7 Pla2g4f Cpne6 Pik3c2b Pik3c2a Mtm1 Pik3c2g Enpp6 Mboat2 Mboat7 Chdh Pnpla2 Pla2g2e Cds2 Pla2g12a Agpat6 Osbpl8 Agpat5 Pla2g2d Etnk1 Pla2g1b Inpp4b Pla2g2f Pnpla8 Inpp4a Osbpl5 Pik3r6 Tpte Arf1 Pik3r5 Lpcat4 Pikfyve Lpcat3 Pla2g4a Fig4 Arf3 Pik3cb Phospho1 Pla2g10 Pla2r1 Pnpla3 Pik3cd Pnpla6 Pla2g16 Awat2 Mboat1 Alpi Osbpl10 Rab14 Gpam Cdipt Lpcat2 Lpin2 Plbd1 Ept1 Pitpnb Inpp5d Pitpnm2 Stard10 Pitpnm3 Pi4k2a Hrasls5 Inpp5f Pik3ca Inpp5e Ptdss2 Ptdss1 Hrasls Rufy1 Ddhd1 Sacm1l Ptpn13 Ache Lpin3 Pla2g3 Lpin1 Stard7 Dmgdh Mtmr14 Pcyt1a Pcyt1b Pip5k1a Pip5k1b Pip5k1c Gdpd1 Sardh Pctp Gdpd5 Rab4a Pip4k2b Cds1 Pip4k2a Bche Tmem86b Pip4k2c Pla2g4c Agpat3 Agpat4 Agpat1 Agpat2 Pisd Pnpla7 Agpat9 Mtmr4 Pik3cg Pik3r3 Pik3r1 Chpt1 Gdpd3 Pik3r2 Gpat2 DNA REPAIR%REACTOME%R-HSA-73894.2 DNA Repair Ube2b Prkdc Poli Usp43 Xrcc5 2810417H13Rik Ufd1l Xrcc6 Vcp Ube2a Rchy1 Rev1 Actb Isg15 Ddb1 Dtl Zbtb32 Ube2l6 Ercc6 Trim25 Trex1 Rfc5 Rfc3 Alkbh2 Rfc2 Alkbh5 Rfc4 Rfc1 Ddb2 Nbn Pole Dna2 Mapk8 Pold1 Pold2 Pold3 Pold4 Apitd1 Uba7 Pole2 Mad2l2 Rpa2 Cul4a Usp10 Rpa1 Atm Rad18 Nploc4 Hist2h2be Sprtn Usp1 Ep300 Fancc Rpa3 Fanci Ube2i Lig1 Fen1 Rad17 Pole4 Cul4b Pole3 Rev3l Hist1h2bg Fancb Hist1h2bh Fancl Fancg Fanca Parg Apex1 Fancm Ube2t Hist1h2bp 2310003H01Rik Hist1h2bm Rbbp8 Dclre1b Ino80 Dclre1a Ruvbl1 Hist1h2bj Stra13 Ercc8 Prpf19 Hist1h2bb Zfp830 Fto Parp1 Alkbh3 Ino80c Ino80b Ino80e Ino80d Nfrkb Cops7b Cops7a Ascc3 Ascc2 Mpg Ascc1 2610002J02Rik Fan1 Uvssa Polb Cops8 C230052I12Rik Cops6 Cops2 Cops4 Cops5 Poln Cops3 Actl6a Tfpt Actr8 Pnkp Mgmt Actr5 Fancf Mutyh Paxip1 Lig4 Ppp4c Smarca5 Tdp2 Tdp1 Lig3 Fam175a Kdm4a Pias4 Polh Apbb1 Pcna Pias3 Kdm4b Clspn Poll Rnf168 Polk Msh2 Eya3 Ube2v2 Dclre1c Eme1 Cdk2 Eya2 Eya1 Brcc3 Eya4 Rad50 Trp53bp1 Ccna1 Baz1b Uimc1 Ccna2 Gen1 Tipin Babam1 Ppp4r2 Rnf4 Sumo3 Isy1 Ppp5c Usp7 Rif1 Top3a Polm Ercc4 Gtf2h1 Rtel1 Ercc1 Brca2 Gtf2h2 Polq Gtf2h5 Gtf2h4 Topbp1 Gtf2h3 Rad9a Ubc Rad9b Rad52 Herc2 Rad51 Timeless Spidr Bre Trp53 Rad51ap1 Sirt6 Tcea1 Parp2 Slx4 Xrcc1 Mus81 Bap1 Whsc1 Hist1h3h Palb2 Xrcc3 Rad51d Xrcc2 Xrcc4 Cdk7 Ppie Msh3 Msh6 Polr2i Polr2j Mnat1 Polr2c Polr2d Atrip Polr2b Bard1 Polr2g Chek2 Mre11a Polr2a Xab2 Rbx1 Ercc3 Rad1 Fancd2 Ercc2 Nthl1 Ogg1 Neil1 Kat5 Ube2n Aqr Mbd4 Neil2 Smug1 Cetn2 Rad51b Rad51c Rnf111 Yy1 Polr2f Polr2e Polr2h Ell Polr2k Chd1l Xpa Ercc5 Pias1 Rad23a Usp45 Hist3h2ba Rad23b Xpc Abl1 Mlh1 Chek1 Rsph10b Blm Hus1 Mdc1 H2afx Exo1 Brip1 Pms2 Wrn Brca1 Ccnh ACTIVATION, TRANSLOCATION AND OLIGOMERIZATION OF BAX%REACTOME%R-HSA-114294.2 Activation, translocation and oligomerization of BAX Bax Bid CELL DIVISION%REACTOME DATABASE ID RELEASE 59%68884 cell division Nudc Wapal Plk1 Stag2 Kif20a Stag1 Pds5a Pds5b Smc3 Smc1a Rad21 Nipbl Mau2 Kif23 PI METABOLISM%REACTOME%R-HSA-1483255.4 PI Metabolism Pik3c3 Pi4k2b Pik3c2b Pik3c2a Pik3r4 Mtm1 Pik3c2g Enpp6 Inpp4b Inpp4a Pik3r6 Pik3r5 Arf1 Tpte Pikfyve Fig4 Arf3 Pik3cb Pik3cd Pnpla6 Rab14 Pitpnb Inpp5d Pi4k2a Inpp5f Pik3ca Inpp5e Rufy1 Sacm1l Ptpn13 Ocrl Mtmr14 Pip5k1a Gde1 Pi4kb Bmx Rab5a Mtmr2 Mtmr1 Mtmr3 Tnfaip8l2 Mtmr7 Mtmr6 Tnfaip8 Inppl1 Tnfaip8l1 Tnfaip8l3 Inpp5k Vac14 Pip5k1b Pip5k1c Gdpd1 Gdpd5 Rab4a Pip4k2b Pip4k2a Pip4k2c Pnpla7 Plekha5 Plekha6 Plekha8 Mtmr4 Pten Synj2 Tmem55b Pik3cg Plekha1 Pik3r3 Plekha2 Pi4ka Pik3r1 Synj1 Gdpd3 Pik3r2 Plekha3 FORMATION OF THE EARLY ELONGATION COMPLEX%REACTOME DATABASE ID RELEASE 59%113418 Formation of the Early Elongation Complex Gtf2h5 Gtf2h4 Gtf2h3 Ercc3 Ercc2 Polr2i Polr2f Polr2j Polr2e Nelfa Polr2h Nelfb Polr2c Mnat1 Polr2d Supt4a Polr2b Polr2k Polr2g Ctdp1 Ccnh Polr2a Cdk7 Nelfe Supt5 Nelfcd Gtf2h1 Gtf2f1 Ncbp1 Ncbp2 Gtf2h2 Gtf2f2 SIGNALING BY NOTCH1 IN CANCER%REACTOME DATABASE ID RELEASE 59%2644603 Signaling by NOTCH1 in Cancer Hdac4 Hdac5 Ccnc Cdk8 Notch1 Skp1a Hdac1 Cul1 Maml2 Aph1b Maml1 Hdac2 Ncor1 Ncor2 Mib2 Crebbp Hdac10 Neurl1a Neurl1b Hey1 Hdac11 Ep300 Hey2 Hdac7 Hdac6 Hdac9 Hdac8 Hes5 Rbpj Kat2b Mib1 Kat2a Heyl Hes1 Adam10 Rbx1 Tbl1x Maml3 Ubc Myc Psen2 Ncstn Mamld1 Adam17 Jag2 Dll1 Tbl1xr1 Dll4 Jag1 Hdac3 RHO GTPASES ACTIVATE ROCKS%REACTOME DATABASE ID RELEASE 59%5627117 RHO GTPases Activate ROCKs Limk1 Limk2 Myl12b Myl12a Myl6 Myh11 Ppp1r12a Ppp1cb Ppp1r12b Rhoa Rhob Myh9 Myh14 Rock1 Myh10 Rhoc Rock2 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL%REACTOME DATABASE ID RELEASE 59%1855183 Synthesis of IP2, IP, and Ins in the cytosol Inpp5a Inpp1 Isyna1 Inpp4b Impa1 Impa2 Inpp4a Ocrl Synj1 Inpp5b THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION)%REACTOME%R-HSA-2453902.2 The canonical retinoid cycle in rods (twilight vision) Rbp1 Napepld Lrat Rbp4 Rdh12 Abca4 Rlbp1 Rdh5 Stra6 Cyp4v3 Hsd17b1 Rdh10 Ttr Rpe65 Myo7a Dhrs9 Hsd17b6 BC089597 Rbp3 Rdh8 Sdr9c7 Rho Rdh11 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS%REACTOME DATABASE ID RELEASE 59%3000171 Non-integrin membrane-ECM interactions Agrn Itgb4 Itga6 Lamc1 Itgb1 Pdgfb Prkca Ttr Fgf2 Cask Lamb1 Itgav Itgb3 Trappc4 Lama5 Sdc3 Lama2 Sdc4 Lama4 Sdc2 Ddr2 Tnc Sdc1 Tgfb1 Lamb3 Dmd Ntn4 Lama1 Lamb2 Lamc3 Dag1 Actn1 Itgb5 Vtn Nrxn1 Lama3 Itga2 Pdgfa Thbs1 Ddr1 Lamc2 Hspg2 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER%REACTOME%R-HSA-3304351.1 Signaling by TGF-beta Receptor Complex in Cancer Tgfbr1 Tgfb1 Fkbp1a Tgfbr2 Smad4 Smad2 Smad3 APOPTOSIS INDUCED DNA FRAGMENTATION%REACTOME DATABASE ID RELEASE 59%140342 Apoptosis induced DNA fragmentation Casp3 Hist1h1c Hist1h1e Hist1h1b Hist1h1a Kpnb1 Hist1h1d Hmgb2 H1f0 Dffb Dffa Kpna1 NEURODEGENERATIVE DISEASES%REACTOME DATABASE ID RELEASE 59%8863678 Neurodegenerative Diseases App Fasl Cdc25c Cdc25b Jun Prdx2 Lmnb1 Prdx1 Ywhae Bcl2l11 Sod2 Capn1 Golga2 Cast Capns1 Capn2 Capns2 Cdc25a Foxo3 Cdk5 Cdk5r1 DNA DAMAGE RECOGNITION IN GG-NER%REACTOME%R-HSA-5696394.1 DNA Damage Recognition in GG-NER Rbx1 Actb Ino80 Ddb1 Ruvbl1 Parp1 Ubc Cetn2 Yy1 Ino80c Ino80b Ddb2 Ino80e Ino80d Nfrkb Cops7b Cops7a Parp2 Cops8 Cops6 Cul4a Cops2 Cops4 Rad23a Cops5 Rad23b Cops3 Xpc Actl6a Tfpt Actr8 Actr5 Cul4b NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY%REACTOME%R-HSA-3301854.2 Nuclear Pore Complex (NPC) Disassembly Nup85 Nup160 Nup37 Nup50 Tpr Nup43 Nup133 Ndc1 Nup214 Aaas Nup210 Cdk1 Nup188 Nup54 Nup35 Nupl2 Nup62 Nup205 Nup155 Nek6 Nup88 Nek7 Pom121 Nek9 Rae1 Ccnb2 Nup93 Nup153 Ranbp2 Nup107 ELEVATION OF CYTOSOLIC CA2+ LEVELS%REACTOME%R-HSA-139853.3 Elevation of cytosolic Ca2+ levels Stim1 Trpc6 Orai1 Orai2 P2rx4 P2rx5 Itpr1 P2rx2 P2rx1 P2rx7 P2rx6 P2rx3 Trpc3 Itpr3 Itpr2 Trpc7 MYOGENESIS%REACTOME DATABASE ID RELEASE 59%525793 Myogenesis Cdh2 Ctnnb1 Mef2b Cdh4 Tcf4 Neo1 Myog Tcf3 Ctnna2 Myf5 Mef2c Mef2a Ctnna1 Map2k6 Spag9 Tbc1d24 Mef2d Bnip2 Tcf12 Myf6 Cdon Myod1 Mapk11 Mapk12 Mapk14 Cdh15 Abl1 AMINE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 59%375280 Amine ligand-binding receptors Htr1d Adra1a Adra1b Adra1d Gpr143 Htr1f Htr7 Chrm3 Adra2a Chrm2 Chrm1 Htr6 Htr5a Adra2c Adra2b Htr4 Chrm5 Chrm4 Htr1b Htr1a Drd4 Drd5 Drd2 Drd3 Drd1 Taar8b Taar1 Htr2a Taar2 Taar5 Taar6 Htr2b Htr2c Taar9 Hrh3 Hrh1 Hrh2 Hrh4 Adrb2 Adrb1 Adrb3 PLATELET DEGRANULATION%REACTOME DATABASE ID RELEASE 59%114608 Platelet degranulation Actn2 Serpine1 Tgfb3 Tgfb2 Plg Brpf3 Pfn1 Vwf Sytl4 Fermt3 Apoh Wdr1 Serping1 App Srgn Gas6 Serpinf2 F5 Fam49b F8 Actn1 Cyb5r1 Maged2 A1bg Lgals3bp Nhlrc2 Pcyox1l Actn4 Calu Endod1 Fam3c Lhfpl2 Manf Chid1 Aplp2 Habp4 Pcdh7 Apool Cdc37l1 Serpina3n Apoa1 Tor4a Islr Timp1 Fgg Pdgfb Vegfa Aldoa Serpina1d Trf Serpina1a Cd36 F13a1 Egf Pros1 Pf4 Itgb3 Tuba4a Tln1 A2m Fga Fgb Thbs1 Hgf Tex264 Psap Ahsg Alb Cfd Abcc4 Cap1 Ola1 Igf2 Clec3b Itga2b Igf1 Ctsw Rab27b Hrg Selp Cd109 Hspa5 Scg3 Stxbp2 Lamp2 Flna Sccpdh Phactr2 Sepp1 Gtpbp2 Clu Tagln2 Tmx3 Timp3 Pecam1 Vcl Ttn Spp2 Orm3 Cd9 Plek Vti1b Ppia Qsox1 Kng2 Ecm1 Mmrn1 Lefty2 Anxa5 Itih3 Rarres2 Ppbp Tgfb1 Cd63 Itih4 Fn1 Sparc Vegfb Vegfc Figf PLC BETA MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 59%112043 PLC beta mediated events Adcy7 Adcy6 Prkcd Adcy5 Adcy4 Adcy3 Adcy2 Prkcg Prkar2a Adcy1 Prkacb Plcb1 Adcy9 Gnaz Plcb2 Adcy8 Prkca Prkar2b Adrbk1 Pla2g4a Mapk1 Gnai2 Creb1 Gnai1 Gnai3 Gnat1 Pde1c Camk4 Gnat2 Pde1b Gnat3 Gnao1 Pde1a Itpr1 Plcb4 Plcb3 Prkar1a Prkar1b Ahcyl1 Prkaca Itpr3 Itpr2 REGULATION OF TP53 ACTIVITY THROUGH PHOSPHORYLATION%REACTOME DATABASE ID RELEASE 59%6804756 Regulation of TP53 Activity through Phosphorylation Prkag2 Prkag1 Prkag3 Trp53rkb Nuak1 Prkaa2 Trp53inp1 Mapkapk5 Trex1 Rfc5 Taf1 Mdm4 Taf2 Rfc3 Cdk2 Pin1 Rfc2 Rad50 Ccna1 Prkaa1 Taf4b Ccna2 Taf7 Rfc4 Taf4a Taf5 Taf6 Taf3 Tbp Nbn Atrip Dna2 Taf9b Bard1 Aurkb Taf9 Aurka Chek2 Ssrp1 Rpa2 Rpa1 Mre11a Atm Rpa3 Top3a Rad17 Taf13 Chek1 Taf11 Csnk2a2 Tpx2 Plk3 Rbbp8 Topbp1 Dyrk2 Rad9a Blm Ubc Rad1 Rad9b Hus1 Prkab1 Taf12 Exo1 Brip1 Cdk5r1 Hipk1 Stk11 Prkab2 Hipk2 Trp53 Ak6 Kat5 Wrn Supt16 Csnk2b Mapk11 Brca1 Mdm2 Mapk14 Cdk5 INOSITOL PHOSPHATE METABOLISM%REACTOME%R-HSA-1483249.2 Inositol phosphate metabolism Plch2 Plch1 Itpkb Itpkc Plcd4 Plcd1 Ppip5k2 Ppip5k1 Nudt10 Plcz1 Minpp1 Plcd3 Plcb1 Plcb2 Ip6k3 Plcg1 Nudt11 Ippk Ip6k1 Ip6k2 Inppl1 Inpp4b Ipmk Inpp4a Inpp5a Inpp1 Isyna1 Impa1 Impa2 Plcg2 Inpp5d Plcb4 Plcb3 Itpk1 Pten Nudt4 Nudt3 Plce1 Itpka Ocrl Synj1 Pld4 Inpp5b FRUCTOSE BIOSYNTHESIS%REACTOME%R-HSA-5652227.2 Fructose biosynthesis Sord Akr1b3 ACROSOME REACTION%REACTOME%R-HSA-1300645.1 Acrosome Reaction Acr HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS%REACTOME DATABASE ID RELEASE 59%163560 Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis Fabp12 Ppp1cc Fabp7 Plin1 Fabp6 Fabp5 Fabp4 Fabp3 Fabp2 Fabp1 Prkacb Fabp9 Cav1 Lipe Abhd5 Ppp1ca Ppp1cb Prkaca Mgll IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX%REACTOME%R-HSA-200425.3 Import of palmitoyl-CoA into the mitochondrial matrix Prkag2 Cpt1b Slc25a20 Prkaa2 Cpt2 Prkab2 Cpt1a Rxra Mid1ip1 Thrsp Ppard FRUCTOSE METABOLISM%REACTOME DATABASE ID RELEASE 59%5652084 Fructose metabolism Aldob Sord Akr1b3 Glyctk Khk Tkfc Aldh1a1 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS%REACTOME%R-HSA-2894862.1 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Hdac4 Hdac5 Ccnc Cdk8 Notch1 Skp1a Hdac1 Cul1 Maml2 Aph1b Maml1 Hdac2 Ncor1 Ncor2 Mib2 Crebbp Hdac10 Neurl1a Neurl1b Hey1 Hdac11 Ep300 Hey2 Hdac7 Hdac6 Hdac9 Hdac8 Hes5 Rbpj Kat2b Mib1 Kat2a Heyl Hes1 Adam10 Rbx1 Tbl1x Maml3 Ubc Myc Psen2 Ncstn Mamld1 Adam17 Jag2 Dll1 Tbl1xr1 Dll4 Jag1 Hdac3 SYNTHESIS OF DOLICHYL-PHOSPHATE-GLUCOSE%REACTOME DATABASE ID RELEASE 59%480985 Synthesis of dolichyl-phosphate-glucose Nudt14 Alg5 VLDL BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 59%8866423 VLDL biosynthesis Mttp Apoc1 Apoc4 P4hb Apob APOPTOTIC EXECUTION PHASE%REACTOME DATABASE ID RELEASE 59%75153 Apoptotic execution phase Casp8 Prkcd Apc Cdh1 Bmx Lmnb1 Clspn Hist1h1d H1f0 Bcap31 Casp3 Add1 Tjp1 Casp7 Tjp2 Prkcq Dsg1a Acin1 Ptk2 Stk26 Stk24 Dsg3 Dsp Dnm1l Dsg2 Plec Fnta Birc2 Satb1 Pkp1 Kpnb1 Hmgb2 Pak2 Dffb Sptan1 Dffa Dbnl Kpna1 Hist1h1c Hist1h1e Hist1h1b Hist1h1a Casp6 Gas2 Rock1 Vim Gsn SIGNALING BY FGFR1%REACTOME DATABASE ID RELEASE 59%5654736 Signaling by FGFR1 Ppp2cb Spry2 Fgf23 Fgfrl1 Flrt3 Fgf22 Ppp2ca Fgf20 Frs2 Nras Ppp2r1a Frs3 Flrt2 Flrt1 Mknk1 Plcg1 Hras Fgf1 Ubc Cbl Gab1 Fgf2 Fgf9 Spred2 Mapk3 Fgf6 Mapk1 Spred1 Fgf4 Fgf3 Kras Fgf18 Pik3ca Sos1 Braf Pik3r1 Ptpn11 Fgf10 TOXICITY OF BOTULINUM TOXIN TYPE B (BONT B)%REACTOME DATABASE ID RELEASE 59%5250958 Toxicity of botulinum toxin type B (BoNT B) Syt2 Syt1 Vamp2 APC-CDC20 MEDIATED DEGRADATION OF NEK2A%REACTOME%R-HSA-179409.2 APC-Cdc20 mediated degradation of Nek2A Cdc23 Ube2d1 Cdc27 Nek2 Bub1b Cdc16 Cdc20 Ube2c Anapc16 Ube2e1 Anapc7 Anapc4 Anapc5 Anapc1 Anapc2 Ubc Bub3 Mad2l1 Anapc15 Anapc11 Anapc10 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY%REACTOME DATABASE ID RELEASE 59%69656 Cyclin A:Cdk2-associated events at S phase entry Psmc6 Psmc5 Psmc2 Psmd2 Psmb9 Psmb8 Psmf1 Rb1 Ccne1 Cdk2 Skp1a Ccne2 Psmc1 Ccna1 Psmc4 Skp2 Psmc3 Cdc25a Cul1 Ccna2 Cdk4 Psme3 Cks1b Max Ccnd1 Fzr1 Ptk6 Mnat1 Cdc25b Cdkn1b Wee1 Cdkn1a Psmd12 Psma7 Psmd11 Psmd14 Psma5 Psmb5 Psmb4 Psmd13 Ubc Psmd10 Psma4 Myc Psmb7 Psma3 Psma6 Psmb6 Psmb2 Psmb3 Psmb1 Psma2 Psma1 Psmd9 Psmd1 Shfm1 Psme2 Psme1 Psmd3 Psmd4 Psmb10 Ccnh Psmd6 Psmd5 Cdk7 Psmd7 Psmd8 AMPK INHIBITS CHREBP TRANSCRIPTIONAL ACTIVATION ACTIVITY%REACTOME%R-HSA-163680.3 AMPK inhibits chREBP transcriptional activation activity Prkag2 Stk11 Adipoq Prkaa2 Prkab2 Mlxipl Adipor2 Adipor1 CLEC7A (DECTIN-1) SIGNALING%REACTOME DATABASE ID RELEASE 59%5607764 CLEC7A (Dectin-1) signaling Psmc6 Prkcd Psmc5 Psmc2 Psmd2 Psmb9 Psmf1 Psmb8 Btrc Psme4 Malt1 Nfkb2 Card11 Nfkb1 Fbxw11 Skp1a Psmc1 Psmc4 Psmc3 Cul1 Psme3 Map3k7 Cdc34 Ppp3cb Tab1 Tab2 Plcg2 Tab3 Card9 Bcl10 Pycard Ppp3ca Clec7a Syk Nfatc2 Ppp3r1 Nfatc1 Nfatc3 Rela Nfkbia Casp8 Chuk Uba3 Psmd12 Psma7 Psmd11 Map3k14 Relb Psmd14 Psma5 Psmb5 Psmb4 Ubc Psmd13 Psma4 Psmd10 Psmb7 Psma3 Psma6 Psmb6 Psmb2 Psmb3 Ube2m Psmb1 Psma2 Psma1 Il1b Psmd9 Ube2d1 Traf6 Ikbkb Ube2v1 Ube2n Psmd1 Shfm1 Psme2 Ikbkg Psme1 Itpr1 Psmd3 Psmd4 Psmb10 Pdpk1 Psmd6 Psmd5 Ahcyl1 Psmd7 Psmb11 Itpr3 Psmd8 Itpr2 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 59%166058 MyD88:Mal cascade initiated on plasma membrane Ppp2r1a Btrc Mapk9 Nfkb2 Nfkb1 Ecsit Fbxw11 Skp1a Saa3 Ppp2r5d Mapkapk3 Tnip2 Myd88 Nod2 Cul1 Nod1 Dhx9 Vrk3 S100b Elk1 Mef2c Mapk10 Mef2a Sigirr Dusp3 Map3k7 Mapk7 Irak3 Peli1 Creb1 Mapkapk2 Irak2 Irak1 App Map2k6 Tab1 Tab2 Jun Mapk8 Tab3 Map3k1 Ripk2 Map2k7 Ager Map2k3 Map2k4 Map3k8 Rela Atf2 Nfkbia Peli3 Nfkbib Irak4 Fos Peli2 Ppp2cb Map2k1 Chuk Ppp2ca Btk Tlr2 Tlr6 Ubc Socs1 Mapk3 Rps6ka5 Mapk1 Ppp2r1b Dusp7 Rps6ka3 Dusp6 Rps6ka2 Rps6ka1 Traf6 Ikbkb Ube2v1 Tlr4 Ube2n Ly96 Cd14 Ikbkg Mapk11 Cd36 Mapk14 Tlr1 Tirap Dusp4 CONJUGATION OF CARBOXYLIC ACIDS%REACTOME%R-HSA-159424.1 Conjugation of carboxylic acids Acsm2 Glyatl3 Acsm1 Glyat Acsm5 Acsm4 NEUROTRANSMITTER RELEASE CYCLE%REACTOME%R-HSA-112310.4 Neurotransmitter Release Cycle Slc6a11 Slc1a3 Slc1a2 Hspa8 Dnajc5 Slc1a7 Slc1a6 Slc38a2 Chat Slc1a1 Slc18a3 Snap25 Gad1 Arl6ip5 Naaa Gad2 Slc32a1 Cask Slc22a2 Gls2 Slc22a1 Slc5a7 Lin7b Abat Gls Slc6a1 Aldh5a1 Slc6a13 Ppfia2 Ppfia1 Apba1 Ppfia4 Syn3 Unc13b Syn1 Syn2 Slc6a12 Rab3a Syt1 Slc18a2 Vamp2 Lin7c Cplx1 Lin7a Maoa Stx1a ATP SENSITIVE POTASSIUM CHANNELS%REACTOME%R-HSA-1296025.1 ATP sensitive Potassium channels Kcnj11 Kcnj8 Abcc8 Abcc9 C-SRC MEDIATED REGULATION OF CX43 FUNCTION AND CLOSURE OF GAP JUNCTIONS%REACTOME DATABASE ID RELEASE 59%191647 c-src mediated regulation of Cx43 function and closure of gap junctions Gja1 Tjp1 FRS-MEDIATED FGFR4 SIGNALING%REACTOME%R-HSA-5654712.3 FRS-mediated FGFR4 signaling Fgf23 Fgf16 Kras Fgf15 Fgf20 Frs2 Klb Nras Fgf18 Frs3 Fgfr4 Hras Sos1 Fgf1 Fgf2 Fgf9 Ptpn11 Fgf6 Fgf4 CHYLOMICRON-MEDIATED LIPID TRANSPORT%REACTOME%R-HSA-174800.5 Chylomicron-mediated lipid transport Sar1b Ldlr Apoc2 Apoc3 Gpihbp1 Lpl Apoa4 Apoa2 Apoe Fgf21 Apoa5 Lipc Pcsk6 Pcsk5 Furin Mttp P4hb Mbtps1 Mbtps2 Angptl3 Creb3l3 Angptl4 Apoa1 Apob Ldlrap1 Gm6484 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION%REACTOME DATABASE ID RELEASE 59%400042 Adrenaline,noradrenaline inhibits insulin secretion Gngt1 Gng7 Adcy6 Adcy5 Gng4 Gngt2 Gng10 Adra2a Adra2c Gnai2 Gnai1 Cacnb2 Cacnb3 Cacna2d2 Cacna1c Cacna1d Gng11 Gng13 Gng12 Gnb2 Gnb1 Gnb3 Gnb5 Gnb4 Gng8 Gng3 Gng2 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER%REACTOME%R-HSA-5696397.1 Gap-filling DNA repair synthesis and ligation in GG-NER Pole Lig3 Pold1 Pold2 Pcna Xrcc1 Pold3 Pold4 Polk Rfc5 Pole2 Rpa2 Rfc3 Ubc Rpa1 Rpa3 Rfc2 Lig1 Rfc4 Pole4 Rfc1 Pole3 DEFECTIVE SFTPA2 CAUSES IDIOPATHIC PULMONARY FIBROSIS (IPF)%REACTOME DATABASE ID RELEASE 59%5687868 Defective SFTPA2 causes idiopathic pulmonary fibrosis (IPF) Sftpd TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA%REACTOME%R-HSA-159230.2 Transport of the SLBP Dependant Mature mRNA Nup85 Nup160 Nup37 Nup50 Tpr Nup43 Nup133 Nxf1 Ndc1 Nup214 Aaas Nup210 Nup188 Nup54 Nup35 Nupl2 Nup62 Nup205 Nup155 Nup88 Pom121 Rae1 Slbp Nup93 Nup153 Eif4e Ranbp2 Nup107 Ncbp1 Ncbp2 Alyref INSULIN PROCESSING%REACTOME DATABASE ID RELEASE 59%264876 Insulin processing Exoc3 Exoc4 Myrip Tmem27 Ero1lb Exoc1 Exoc5 Exoc6 Exoc8 Exoc7 Exoc2 Cpn1 Ins2 Kif5a Kif5b Slc30a5 Slc30a8 Cpe Ero1l Myo5a Rab27a Slc30a6 Slc30a7 Vamp2 Pcsk1 Kif5c Pcsk2 Stx1a DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 59%2474795 Diseases associated with visual transduction Rbp1 Napepld Opn1sw Rbp4 Opn1mw Rlbp1 Stra6 Ttr BUTYRATE RESPONSE FACTOR 1 (BRF1) BINDS AND DESTABILIZES MRNA%REACTOME%R-HSA-450385.2 Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Dcp1a Ywhab Mapkapk2 Exosc9 Exosc8 Exosc7 Exosc5 Exosc4 Dcp2 Zfp36l1 Dis3 Xrn1 Exosc3 Akt1 Exosc1 Exosc2 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX%REACTOME DATABASE ID RELEASE 59%141430 Inactivation of APC C via direct inhibition of the APC C complex Cdc23 Ube2d1 Cdc27 Bub1b Cdc16 Cdc20 Ube2c Anapc16 Ube2e1 Anapc7 Anapc4 Anapc5 Anapc1 Anapc2 Bub3 Mad2l1 Anapc15 Anapc11 Anapc10 PREGNENOLONE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 59%196108 Pregnenolone biosynthesis Fdx1 Fdx1l Star Akr1b3 Stard4 Cyp11a1 Stard3nl Stard3 Fdxr TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS%REACTOME DATABASE ID RELEASE 59%2173789 TGF-beta receptor signaling activates SMADs Xpo1 Ubc Ppp1cb Cbl Ube2m Ppp1cc Tgfb1 Smurf1 Smad4 Smad2 Smad7 Stub1 Uchl5 Smad3 Nedd8 Furin Ppp1ca Strap Ppp1r15a Nedd4l Mtmr4 Tgfbr1 Pmepa1 Bambi Fkbp1a Usp15 Tgfbr2 Smurf2 TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING%REACTOME%R-HSA-975110.1 TRAF6 mediated IRF7 activation in TLR7 8 or 9 signaling Irf7 Irak1 Tlr9 Irak4 Tlr8 Traf6 Tlr7 Ube2v1 Myd88 Ube2n Dhx36 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND%REACTOME DATABASE ID RELEASE 59%69183 Processive synthesis on the lagging strand Dna2 Pold1 Pold2 Pold3 Pcna Pold4 Prim1 Rpa2 Rpa1 Rpa3 Pola1 Pola2 Lig1 Fen1 Prim2 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE%REACTOME DATABASE ID RELEASE 59%3359478 Defective MUT causes methylmalonic aciduria mut type Mut Mmaa INTRA-GOLGI TRAFFIC%REACTOME DATABASE ID RELEASE 59%6811438 Intra-Golgi traffic Cog6 Cog3 Cog4 Cog2 Stx5a Cog1 Rab36 Snap29 Rgp1 Nsf Rab30 Rab33b Cux1 Trip11 Stx16 Rab39 Man1c1 Bet1l Gosr1 Man1a Gosr2 Arf1 Napb Napg Napa Cyth2 Golim4 Cyth1 Vti1a Stx6 Vps45 Golga5 Cyth4 Cyth3 Alppl2 Man1a2 Ric1 Man2a1 Cog7 Ykt6 Cog8 APEX1-INDEPENDENT RESOLUTION OF AP SITES VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 59%5649702 APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway Ogg1 Neil1 Lig3 Xrcc1 Pnkp Neil2 Polb N-GLYCAN ANTENNAE ELONGATION%REACTOME DATABASE ID RELEASE 59%975577 N-Glycan antennae elongation Mgat5 St8sia3 St8sia2 St8sia6 B4galt3 B4galt1 Mgat4a Mgat4b B4galt5 St3gal4 B4galt4 B4galt6 B4galt2 St6gal1 Mgat4c HIV LIFE CYCLE%REACTOME DATABASE ID RELEASE 59%162587 HIV Life Cycle Gtf2a1 Xrcc5 Nup85 Xrcc6 Nup160 Gtf2a2 Cdk9 Gtf2b Hmga1 Xpo1 Taf1 Taf2 Taf4b Taf7 Taf4a Rngtt Taf5 Taf6 Rnmt Taf3 Polr2i Polr2j Gtf2e1 Nelfa Nelfb Gtf2e2 Polr2c Mnat1 Polr2d Supt4a Polr2b Taf9 Polr2g Ccnt1 Ctdp1 Psip1 Nedd4l Banf1 Nup107 Polr2a Nelfe Supt5 Nelfcd Lig1 Gtf2f1 Fen1 Ccnt2 Ncbp1 Ncbp2 Gtf2f2 Chmp5 Chmp7 Taf13 Chmp6 Taf11 Chmp3 Vps37d Rcc1 Vps37c Nup37 Vps37b Pdcd6ip Tonsl Nup43 Vps4b Nup133 Vps4a Vta1 Chmp2a Chmp4c Chmp4b Ercc3 Nmt2 Vps37a Ranbp1 Ccr5 Nmt1 Taf12 Cxcr4 Ercc2 Tsg101 Ranbp2 Cd4 Lig4 Nup50 Tpr Ndc1 Nup214 Aaas Nup210 Nup188 Nup54 Nup35 Nupl2 Nup62 Nup205 Nup155 Nup88 Pom121 Rae1 Polr2f Polr2e Polr2h Tbp Nup93 Ell Nup153 Taf9b Polr2k Furin Ssrp1 Ran Gtf2h1 Gtf2h2 Gtf2h5 Gtf2h4 Gtf2h3 Ubc Ppia Tcea1 Ak6 Tceb1 Tceb3 Supt16 Kpna1 Ccnh Ccnk Xrcc4 Cdk7 NUCLEAR ENVELOPE BREAKDOWN%REACTOME%R-HSA-2980766.1 Nuclear Envelope Breakdown Nup85 Nup160 Nup37 Vrk1 Nup50 Lmnb1 Nup43 Plk1 Tpr Nup133 Prkcb Prkca Ndc1 Nup214 Emd Aaas Cdk1 Nup210 Nup188 Nup54 Nup35 Nupl2 Nup62 Nup205 Nup155 Nek6 Nup88 Lemd3 Nek7 Pom121 Lemd2 Ctdnep1 Rae1 Nek9 Cnep1r1 Ccnb2 Nup93 Lpin2 Nup153 Ranbp2 Banf1 Nup107 Lpin3 Lpin1 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 59%3304356 SMAD2 3 Phosphorylation Motif Mutants in Cancer Tgfbr1 Tgfb1 Tgfbr2 Smad2 Smad3 CLASSICAL ANTIBODY-MEDIATED COMPLEMENT ACTIVATION%REACTOME%R-HSA-173623.2 Classical antibody-mediated complement activation Crp C1rb C1s2 C1qc C1qb C1qa REGULATION OF TP53 ACTIVITY THROUGH ASSOCIATION WITH CO-FACTORS%REACTOME DATABASE ID RELEASE 59%6804759 Regulation of TP53 Activity through Association with Co-factors Trp53bp2 Phf20 Trp53 Trp63 Akt2 Akt3 Ppp1r13b Ppp1r13l Pou4f1 Trp73 Pou4f2 Banp Akt1 Zfp385a ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK%REACTOME DATABASE ID RELEASE 59%380972 Energy dependent regulation of mTOR by LKB1-AMPK Prkag2 Prkag1 Ppm1a Prkag3 Lamtor2 Lamtor5 Prkaa2 Tsc2 Rragd Rragb Rragc Tsc1 Rraga Mlst8 Lamtor4 Mtor Prkaa1 Prkab1 Rptor Stk11 Prkab2 Cab39 Strada Stradb Cab39l Lamtor1 O2 CO2 EXCHANGE IN ERYTHROCYTES%REACTOME%R-HSA-1480926.1 O2 CO2 exchange in erythrocytes Cyb5rl Aqp1 Hba-a1 Slc4a1 Car4 Car2 Hbb-bs Cyb5r2 Cyb5r1 Car1 Cyb5r4 Hbb-bt Rhag REGULATION OF GENE EXPRESSION IN BETA CELLS%REACTOME DATABASE ID RELEASE 59%210745 Regulation of gene expression in beta cells Hnf4g Iapp Ins2 Akt2 Akt3 Hnf1a Rfx6 Nkx6-1 Neurod1 Foxa2 Mafa Foxa3 Pdx1 Slc2a2 Nkx2-2 Akt1 Foxo1 Gck Pax6 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA-HYDROXYCHOLESTEROL%REACTOME DATABASE ID RELEASE 59%193368 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol Akr1c6 Acox2 Hsd17b4 Cyp7a1 Cyp7b1 Rxra Baat Acot8 Abcb11 Nr1h4 Ptgis Slc27a5 Akr1c18 Cyp27a1 Akr1d1 Amacr Hsd3b7 Akr1c21 Ncoa1 Cyp8b1 Ncoa2 Slc27a2 REGULATION OF FZD BY UBIQUITINATION%REACTOME%R-HSA-4641263.2 Regulation of FZD by ubiquitination Fzd6 Usp8 Wnt3a Znrf3 Ubc Rspo2 Lgr4 Rspo4 Rspo3 Lgr6 Fzd4 Rspo1 Fzd5 Fzd8 Lgr5 Lrp6 Lrp5 Rnf43 DISORDERS OF TRANSMEMBRANE TRANSPORTERS%REACTOME DATABASE ID RELEASE 59%5619115 Disorders of transmembrane transporters Psmc6 Psmc5 Psmc2 Vcp Psmd2 Os9 Rnf185 Derl2 Rnf5 Psmb9 Psmf1 Psmb8 Psme4 Sel1l Psmc1 Psmc4 Psmc3 Psme3 Alb Psmd12 Psma7 Cftr Psmd11 Erlin2 Psmd14 Psma5 Psmb5 Psmb4 Ubc Psmd13 Psmd10 Psma4 Psmb7 Psma3 Psma6 Psmb6 Psmb2 Psmb3 Psmb1 Psma2 Psma1 Psmd9 Erlin1 Gckr Sftpb Sftpc Psmd1 Shfm1 Psme2 Sftpa1 Sftpd Derl1 Psme1 Derl3 Kcnj11 Abcc8 Psmd3 Psmd4 Psmb10 Avp Psmd6 Psmd5 Avpr1a Avpr2 Avpr1b Psmd7 Psmb11 Psmd8 Erlec1 Gck B-WICH COMPLEX POSITIVELY REGULATES RRNA EXPRESSION%REACTOME DATABASE ID RELEASE 59%5250924 B-WICH complex positively regulates rRNA expression Smarca5 Actb Ercc6 Hist2h3c1 Polr1a Polr1e Znrd1 Baz1b H2afj Polr2f H2afb2 Polr2e Polr2h Tbp Polr1b Polr2k Hist3h2ba Hist2h2be Ep300 Polr1d Polr1c Hist2h2ac Kat2b H3f3b Kat2a H3f3a Ddx21 Hist1h2bg Hist1h2bh Cd3eap Hist1h2bp Hist1h2bm Hist1h2bj Hist1h2bb Sf3b1 H2afz Taf1d H2afx Taf1c Taf1b Taf1a Dek Hist2h2aa1 Gsk3b Hist1h3d Hist1h2ak Hist1h2ag Mybbp1a Hist1h2ah DEPYRIMIDINATION%REACTOME%R-HSA-73928.1 Depyrimidination Nthl1 Ogg1 Neil1 Mbd4 Neil2 Smug1 HYALURONAN BIOSYNTHESIS AND EXPORT%REACTOME DATABASE ID RELEASE 59%2142850 Hyaluronan biosynthesis and export Has3 Abcc5 Has1 Cemip Has2 LIPID AND LIPOPROTEIN METABOLISM%REACTOME DATABASE ID RELEASE 59%73923 Lipid and lipoprotein metabolism Ldlr Apoa4 Nr1h2 Apoa2 Ppp1cc Pnlip Mbtps1 Mbtps2 Apoa1 Apob Clps Ap2m1 Apoc2 Apoc3 Gpihbp1 Ap2a1 Lpl Ap2a2 Apoe Ap2s1 Mgll Clta Ap2b1 Cltc Mttp Apoc1 Apoc4 P4hb Npc1 Npc2 Hdlbp Sar1b Soat1 Soat2 Lmf2 Lmf1 Prkacb Reln Fabp12 Fyn Lipk Fabp7 Abca1 Plin1 Fitm1 Fitm2 Fabp6 Fabp5 Lipa Apof Fabp4 Ces3b Fabp3 Fabp2 Pnliprp1 Abcg1 Fabp1 Zdhhc8 Fabp9 Lsr Cav1 Lipe Lipf Sh3kbp1 Abhd5 Lipg Liph Lipn Furin Cidec Cidea Abcg5 A2m Mylip Dab1 Abcg8 Pnliprp2 Nr1h3 Hsd17b13 Prkaca Pcsk9 Apobr Lcat Nceh1 Hilpda Vldlr Cel Alb Ppp1cb Fgf21 Apoa5 Lipc Pcsk6 Pcsk5 Ppp1ca Amn Cubn Angptl3 Creb3l3 Angptl4 Ldlrap1 Gm6484 TWIK-RELATED SPINAL CORD K+ CHANNEL (TRESK)%REACTOME%R-HSA-1299344.1 TWIK-related spinal cord K+ channel (TRESK) Kcnk18 SIGNALING BY EGFRVIII IN CANCER%REACTOME DATABASE ID RELEASE 59%5637812 Signaling by EGFRvIII in Cancer Shc1 Egf Kras Nras Hsp90aa1 Cdc37 Plcg1 Pik3ca Hras Sos1 Egfr Gab1 Cbl Pik3r1 ESTROGEN BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 59%193144 Estrogen biosynthesis Cyp19a1 Hsd17b11 Hsd17b2 Akr1b8 Hsd17b14 Hsd17b1 RSK ACTIVATION%REACTOME%R-HSA-444257.1 RSK activation Rps6ka6 Rps6ka3 Pdpk1 Rps6ka2 Rps6ka1 Mapk1 REMOVAL OF LICENSING FACTORS FROM ORIGINS%REACTOME%R-HSA-69300.2 Removal of licensing factors from origins Psmc6 Psmc5 Psmc2 Psmd2 Psmb9 Psmf1 Psmb8 Rb1 Psme4 Mcm6 Cdc6 Cdk2 Mcm3 Mcm2 Mcm5 Mcm4 Psmc1 Ccna1 Psmc4 Psmc3 Ccna2 Psme3 Fzr1 Gmnn Orc4 Orc5 Mcm8 Mcm7 Cdt1 Orc2 Orc3 Orc6 Orc1 Cdkn1b Cdkn1a Psmd12 Psma7 Psmd11 Psmd14 Psma5 Psmb5 Psmb4 Ubc Psmd13 Psmd10 Psma4 Psmb7 Psma3 Psma6 Psmb6 Psmb2 Psmb3 Psmb1 Psma2 Mcm10 Psma1 Psmd9 Psmd1 Shfm1 Psme2 Psme1 Psmd3 Psmd4 Psmb10 Psmd6 Psmd5 Psmd7 Psmb11 Psmd8 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS%REACTOME%R-HSA-2029480.1 Fcgamma receptor (FCGR) dependent phagocytosis Dock1 Prkcd Prkce Actb Hsp90aa1 Wipf3 Vav1 Wipf2 Wipf1 Wasf2 Pla2g6 Ptk2 Pik3cb Wasf3 Arpc5 Elmo1 Arpc4 Elmo2 Wasf1 Fyn Hck Myo1c Fcgr4 Myh2 Myo9b Ppapdc1a Ppapdc1b Rac1 Fgr Plcg2 Myo10 Pak1 Fcgr3 Syk Fcgr1 Pik3ca Myo5a Wasl Was Abl1 Vav3 Pld3 Actg1 Btk Plcg1 Yes1 Lyn Nckap1l Baiap2 Nck1 Mapk3 Brk1 Mapk1 Abi1 Abi2 Limk1 Arpc1a Actr2 Actr3 Arpc1b Vav2 Nckipsd Itpr1 Nckap1 Ahcyl1 Hsp90ab1 Arpc3 Pld2 Crk Pld1 Pik3r1 Arpc2 Myh9 Itpr3 Cyfip1 Pld4 Cd3g Itpr2 Pik3r2 Cyfip2 TRANSCRIPTIONAL REGULATION BY SMALL RNAS%REACTOME DATABASE ID RELEASE 59%5578749 Transcriptional regulation by small RNAs Nup85 Nup160 Nup50 Tpr Ndc1 Nup214 Hist2h3c1 Aaas Nup210 Nup188 Nup54 Nup35 Nupl2 Nup62 Nup205 Nup155 Nup88 Pom121 H2afj Rae1 H2afb2 Polr2f Polr2i Polr2e Polr2j Polr2h Nup93 Polr2c Polr2d Nup153 Polr2b Polr2g Polr2k Hist3h2ba Hist2h2be Nup107 Polr2a Hist2h2ac Ran Ipo8 H3f3b H3f3a Hist1h2bg Hist1h2bh Nup37 Hist1h2bp Hist1h2bm Nup43 Nup133 Hist1h2bj Hist1h2bb H2afz H2afx Ago2 Ago1 Hist2h2aa1 Hist1h3d Tnrc6a Hist1h2ak Ranbp2 Hist1h2ag Hist1h2ah SYNTHESIS OF 15-EICOSATETRAENOIC ACID DERIVATIVES%REACTOME DATABASE ID RELEASE 59%2142770 Synthesis of 15-eicosatetraenoic acid derivatives Gpx2 Ptgs2 Gpx1 Alox8 Alox15 Gpx4 TRANSPORT AND SYNTHESIS OF PAPS%REACTOME%R-HSA-174362.2 Transport and synthesis of PAPS Slc35b2 Slc26a1 Slc26a2 Slc35b3 Papss2 Papss1 CALNEXIN CALRETICULIN CYCLE%REACTOME DATABASE ID RELEASE 59%901042 Calnexin calreticulin cycle Canx Ganab Os9 Calr Rnf185 Derl2 Rnf5 Rnf139 Man1b1 Uggt2 Pdia3 Edem3 Amfr Trim13 Uggt1 Edem2 Ubc Edem1 Rnf103 Syvn1 Sel1l March6 Prkcsh REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND%REACTOME%R-HSA-174437.1 Removal of the Flap Intermediate from the C-strand Rpa2 Rpa1 Dna2 Rpa3 Pold1 Pold2 Pcna Pold3 Pold4 Fen1 GAB1 SIGNALOSOME%REACTOME%R-HSA-180292.1 GAB1 signalosome Casp9 Tsc2 Pdgfrb Pdgfra Ppp2r1a Mlst8 Vav1 Egfr Gab1 Mtor Phlpp1 Phlpp2 Ins2 Cd86 Cdkn1a Pdgfb Cd80 Kit Ppp2r1b Ago2 Ago1 Tnrc6c Insr Gsk3a Gsk3b Tnrc6b Tnrc6a Ago4 Ago3 Trat1 Irs2 Mdm2 Lck Pten Hbegf Irs1 Btc Ptpn11 Trib3 Egf Fgf23 Pag1 Fgf22 Fgf20 Frs2 Ppp2r5e Mapkap1 Fgf1 Bad Ppp2r5c Rps6kb2 Fgf2 Csk Ppp2r5d Ppp2r5a Erbb2 Fgf9 Pik3cb Fgf7 Foxo3 Pik3cd Fgf6 Foxo1 Fgf4 Fgf3 Fyn Creb1 Ppp2r5b Ier3 Pik3ca Cdkn1b Nr4a1 Prr5 Hgf Ppp2cb Pip5k1a Chuk Ereg Nrg2 Ppp2ca Nrg1 Akt2 Akt3 Fgfr4 Pxn Nrg3 Nrg4 Akt1s1 Mapk3 Pip5k1b Akt1 Mapk1 Cd19 Pip5k1c Fgf16 Pip4k2b Pip4k2a Fgf15 Trp53 Pip4k2c Klb Fgf18 Pik3ap1 Them4 Met Rictor Pdpk1 Pik3r3 Pik3r1 Fgf10 Pik3r2 Mov10 DOWNREGULATION OF ERBB4 SIGNALING%REACTOME DATABASE ID RELEASE 59%1253288 Downregulation of ERBB4 signaling Ubc Itch Wwp1 Nedd4 TOLERANCE OF REACTIVE OXYGEN PRODUCED BY MACROPHAGES%REACTOME%R-HSA-1222387.1 Tolerance of reactive oxygen produced by macrophages WAX BIOSYNTHESIS%REACTOME%R-HSA-8848584.1 Wax biosynthesis Far1 Awat1 Awat2 Far2 NEGATIVE REGULATION OF ACTIVITY OF TFAP2 (AP-2) FAMILY TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 59%8866904 Negative regulation of activity of TFAP2 (AP-2) family transcription factors Tfap2b Tfap2a Tfap2d Tfap2c Wwox Tfap2e Kctd15 Ube2i Kctd1 NOSTRIN MEDIATED ENOS TRAFFICKING%REACTOME DATABASE ID RELEASE 59%203641 NOSTRIN mediated eNOS trafficking Wasl Dnm2 Nos3 Nostrin Cav1 ACETYLATION%REACTOME%R-HSA-156582.1 Acetylation Nat2 Nat1 OLFACTORY SIGNALING PATHWAY%REACTOME%R-HSA-381753.2 Olfactory Signaling Pathway Olfr1256 Olfr1259 Olfr1258 Olfr1193 Olfr1014 Olfr1019 Olfr1020 Olfr1023 Olfr1022 Olfr1029 Olfr1032 Olfr1031 Olfr796 Olfr504 Olfr508 Olfr1288 Olfr780 Olfr782 Olfr786 Olfr788 Olfr516 Olfr518 Olfr1469 Olfr1461 Olfr1264 Olfr1265 Olfr1451 Olfr1252 Olfr1006 Olfr63 Olfr64 Olfr65 Olfr68 Olfr71 Olfr76 Olfr78 Olfr1008 Olfr73 Olfr1046 Olfr1047 Olfr1173 Olfr1034 Olfr1044 Olfr1045 Olfr96 Olfr91 Olfr95 Olfr66 Olfr90 Olfr1156 Olfr1157 Olfr1052 Olfr705 Olfr1155 Olfr583 Olfr631 Olfr1357 Olfr980 Olfr635 Olfr1352 Olfr982 Olfr1162 Olfr1206 Olfr18 Olfr589 Olfr1356 Olfr1209 Olfr309 Olfr16 Olfr17 Olfr3 Olfr1093 Olfr314 Olfr173 Olfr2 Olfr1094 Olfr985 Olfr986 Olfr310 Olfr315 Olfr984 Olfr706 Olfr159 Olfr728 Olfr727 Olfr729 Olfr722 Olfr723 Olfr1414 Olfr720 Olfr1423 Olfr1425 Olfr1416 Olfr520 Olfr152 Gnal Olfr1408 Olfr231 Olfr160 Olfr305 Olfr165 Olfr164 Olfr1404 Olfr919 Olfr586 Olfr308 Olfr167 Olfr714 Olfr166 Olfr713 Olfr168 Olfr993 Olfr715 Olfr1204 Gm4461 Olfr222 Olfr220 Olfr221 Olfr1234 Olfr421-ps1 Olfr229 Olfr790 Olfr1211 Olfr1497 Olfr1496 Olfr1490 Olfr1494 Olfr211 Olfr198 Olfr979 Olfr978 Olfr183 Olfr180 Olfr569 Olfr568 Olfr974 Olfr592 Olfr186 Olfr187 Olfr1240 Olfr574 Olfr571 Olfr577 Olfr578 Olfr576 Olfr196 Olfr193 Olfr685 Olfr684 Olfr683 Reep5 Reep4 Reep3 Olfr410 Olfr411 Olfr412 Olfr414 Reep1 Olfr677 Olfr1311 Olfr478 Olfr675 Olfr687 Reep2 Reep6 Olfr402 Olfr681 Olfr175-ps1 Olfr821 Olfr32 Olfr1385 Olfr419 Olfr417 Olfr809 Olfr808 Olfr692 Olfr691 Olfr429 Olfr430 Olfr825 Olfr298 Olfr420 Olfr288 Olfr832 Olfr1500 Olfr323 Olfr322 Olfr20 Olfr145 Olfr24 Olfr735 Olfr1509 Olfr1426 Olfr1428 Olfr1505 Olfr57 Olfr55 Olfr1420 Olfr730 Olfr732 Olfr147 Olfr1512 Olfr733 Olfr1511 Olfr734 Olfr137 Olfr31 Olfr350 Olfr745 Olfr744 Olfr1102 Olfr357 Olfr749 Olfr1100 Olfr351 Olfr558 Olfr557 Olfr1104 Olfr556 Olfr554 Olfr26 Olfr1434 Olfr552 Olfr750 Olfr125 Olfr348 Olfr354 Olfr1360 Olfr355 Olfr618 Olfr11 Olfr1444 Olfr1445 Olfr15 Olfr13 Olfr1123 Olfr43 Olfr44 Olfr47 Olfr1396 Olfr1111 Gngt1 Rtp2 Olfr376 Olfr370 Olfr372 Gnb1 Rtp4 Rtp3 Rtp1 Olfr448 Olfr648 Olfr447 Olfr263 Olfr444 Olfr646 Olfr1309 Olfr446 Olfr267 Olfr365 Olfr362 Olfr101 Olfr368 Olfr110 Olfr109 Olfr669 Olfr464 Olfr666 Olfr870 Olfr874 Olfr867 Olfr658 Olfr453 Olfr878 Olfr243 Olfr460 Olfr463 Olfr854 Olfr272 Olfr275 Olfr270 Olfr273 Olfr452 Olfr449 Olfr640 Olfr641 Olfr853 PHENYLALANINE AND TYROSINE CATABOLISM%REACTOME DATABASE ID RELEASE 59%71182 Phenylalanine and tyrosine catabolism Hpd Qdpr Gstz1 Ccbl1 Pah Il4i1 Pcbd1 Hgd Tat Fah Asrgl1 PYRUVATE METABOLISM%REACTOME DATABASE ID RELEASE 59%70268 Pyruvate metabolism Ldhc Pdhb Dlat Pdpr Glo1 Ldha Ldhb Pdp2 Pdp1 Pdhx Pdha1 Ldhal6b Pdk1 Pdk2 Mpc1 Mpc2 Pdk3 Pdk4 Rxra Dld Slc16a3 Slc16a1 Bsg Slc16a8 Ppard REELIN SIGNALLING PATHWAY%REACTOME DATABASE ID RELEASE 59%8866376 Reelin signalling pathway Fyn Reln Dab1 Sh3kbp1 Vldlr EUKARYOTIC TRANSLATION ELONGATION%REACTOME%R-HSA-156842.2 Eukaryotic Translation Elongation Rpl39 Rplp1 Rpl7 Rps21 Rps27 Rplp2 Rps25 Rpl4 Rps26 Rps27l Rpl18a Rpl34 Rpl32 Rpl26 Rpl24 Rps9 Rps7 Rps5 Rpl22 Rpl10l Rpl23 Eef2 Rpl39l Rpl13a Rpl22l1 Rps15a Rpl11 Eef1b2 Rpl17 Eef1g Rps3 Rpl19 Eef1d Rpl18 Rps16 Rps14 Rps19 Rps18 Rps11 Eef1a2 Rps10 Rpsa Rpl37 Rps4x KSRP (KHSRP) BINDS AND DESTABILIZES MRNA%REACTOME DATABASE ID RELEASE 59%450604 KSRP (KHSRP) binds and destabilizes mRNA Exosc9 Ywhaz Exosc8 Exosc7 Exosc5 Exosc4 Parn Mapk11 Mapk14 Dcp2 Dis3 Exosc3 Akt1 Exosc1 Exosc2 VEGFA-VEGFR2 PATHWAY%REACTOME%R-HSA-4420097.2 VEGFA-VEGFR2 Pathway Akap9 Ppp2r1a Prkcb Mapkapk3 Wasf2 Wasf3 Wasf1 Ctnna1 Cybb Cyba Rac1 Pak1 Csf2 Ptk2b Jak1 Nckap1l Itgav Abi1 Abi2 Vav2 Nckap1 Cyfip1 Cyfip2 Frs2 Nras Frs3 Rasgrf1 Psmf1 Raf1 Psme4 Ncf4 Il5ra Fgf1 Il17rd Ncf2 Fgf2 Cnksr1 Csk Ncf1 Cnksr2 Erbb2 Fgf9 Ptk2 Fgf7 Psme3 Fgf6 Fgf4 Fgf3 Ppp5c Ranbp9 Rock1 Rock2 Ppp2cb Shc1 Lamtor2 Nrg2 Hspb1 Ppp2ca Shc3 Nrg1 Akt2 Akt3 Shc2 Psma7 Artn Nrtn Plcg1 Brap Nck2 Psmb5 Psmb4 Ubc Nrg3 Psmb7 Nrg4 Psmb6 Psmb2 Psmb3 Psmb1 Nck1 Mapk3 Akt1 Mapk1 Ksr1 Ptpra Dusp16 Dusp10 Map3k11 Paqr3 Psme2 Psme1 Ncam1 Sos1 Rictor Braf Psmb10 Apbb1ip Ahcyl1 Psmb11 Csf2rb2 Rapgef2 Csf2ra Dock1 Prkcd Actn2 Nf1 Pdgfrb Pdgfra Mlst8 Kbtbd7 Prkca Vav1 Il2rg Arrb2 Egfr Arrb1 Mtor Ret Rhoa Vwf Elmo1 Elmo2 Mapkapk2 Sptan1 Pspn Map2k1 Rbx1 Fgg Map2k2 Cul3 Psmd12 Pdgfb Psmd11 Rasgef1a Psmd14 Rasa3 Rasa4 Psmd13 Psmd10 Il2 Rasa2 Rasa1 Nefl Spred3 Kit Spred2 Kdr Grin2a Spred1 Spta1 Il5 Sptbn4 Ppp2r1b Ywhab Kras Gdnf Pak3 Shfm1 Pak2 Itpr1 Irs2 Syngap1 Hbegf Irs1 Il3ra Btc Il2ra Il2rb Itpr3 Angpt1 Itpr2 Trib3 Psmc6 Egf Fgf23 Psmc5 Fgf22 Mark3 Psmc2 Fgf20 Psmd2 Dab2ip Nos3 Prkacb Tek Psmb9 Hsp90aa1 Psmb8 Araf Hras Sphk1 Grin1 Shb Ppp2r5e Mapkap1 Dlg4 Ppp2r5c Ppp2r5d Ppp2r5a Psmc1 Psmc4 Psmc3 Pik3cb Sptbn2 Axl Sptbn1 Sh2d2a Itgb3 Fyn Phb Grin2c Rasgrp4 Rasgrp3 Pebp1 Cav1 Ppp2r5b Rasgrp1 Tln1 Pik3ca Fga Fgb Grin2d Prkaca Grin2b Sptb Prr5 Vav3 Hgf Gfra2 Gfra3 Jup Ctnnd1 Gfra4 Ereg Jak2 Pea15a Itga2b Rap1a Jak3 Cdh5 Wdr83 Camk2d Rap1b Camk2a Fgfr4 Camk2b Psma5 Rasal3 Pxn Rasal2 Psma4 Psma3 Psma6 Vcl Baiap2 Camk2g Psma2 Psma1 Brk1 Gfra1 Psmd9 Dusp7 Iqgap1 Fgf16 Dusp6 Dusp9 Fgf15 Dusp8 Klb Fgf18 Them4 Psmd1 Met Prkcz Fn1 Bcar1 Mapk11 Rasal1 Dusp1 Mapk13 Psmd3 Mapk12 Psmd4 Mapk14 Pdpk1 Psmd6 Psmd5 Dusp2 Psmd7 Crk Pik3r1 Dusp5 Psmd8 Fgf10 Pik3r2 Dusp4 NOSIP MEDIATED ENOS TRAFFICKING%REACTOME DATABASE ID RELEASE 59%203754 NOSIP mediated eNOS trafficking Nos3 Nosip LYSOSOMAL OLIGOSACCHARIDE CATABOLISM%REACTOME%R-HSA-8853383.1 Lysosomal oligosaccharide catabolism Man2c1 Man2b2 Manba Man2b1 TRP CHANNELS%REACTOME DATABASE ID RELEASE 59%3295583 TRP channels Trpv1 Trpv3 Trpv2 Trpc6 Trpv4 Trpa1 Trpm2 Trpc4 Trpm1 Trpm7 Mcoln3 Mcoln2 Trpc5 Trpm3 Trpm6 Trpm5 Trpm8 Trpm4 Trpc4ap Mcoln1 Trpc1 Trpc3 Trpv6 Trpc7 Trpv5 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%R-HSA-3315487.1 SMAD2 3 MH2 Domain Mutants in Cancer Tgfbr1 Tgfb1 Tgfbr2 Smad4 Smad2 Smad3 TRANSCRIPTION OF THE HIV GENOME%REACTOME%R-HSA-167172.2 Transcription of the HIV genome Gtf2a1 Gtf2a2 Cdk9 Gtf2b Taf1 Taf2 Taf4b Taf7 Taf4a Rngtt Taf5 Taf6 Rnmt Taf3 Polr2f Polr2i Gtf2e1 Polr2e Polr2j Polr2h Nelfa Gtf2e2 Tbp Nelfb Mnat1 Ell Polr2c Polr2d Supt4a Polr2b Taf9b Taf9 Polr2g Polr2k Ccnt1 Ctdp1 Ssrp1 Polr2a Nelfe Supt5 Nelfcd Gtf2h1 Gtf2f1 Ccnt2 Ncbp1 Ncbp2 Gtf2h2 Gtf2f2 Gtf2h5 Taf13 Gtf2h4 Taf11 Gtf2h3 Ercc3 Taf12 Ercc2 Ak6 Tcea1 Tceb1 Tceb3 Supt16 Ccnh Ccnk Cdk7 CD28 DEPENDENT PI3K AKT SIGNALING%REACTOME DATABASE ID RELEASE 59%389357 CD28 dependent PI3K Akt signaling Fyn Akt2 Akt3 Them4 Map3k14 Cd80 Mlst8 Map3k8 Pik3ca Rictor Mapkap1 Pdpk1 Lck Mtor Pik3r3 Pik3r1 Prr5 Akt1 Pik3r2 Trib3 Cd86 EPH-EPHRIN SIGNALING%REACTOME DATABASE ID RELEASE 59%2682334 EPH-Ephrin signaling Actb Efna2 Hsp90aa1 Efna1 Efna3 Hras Grin1 Shb Rhoa Ptk2 Arpc5 Arpc4 Aph1b Efna4 Fyn Efnb3 Arhgef28 Efnb1 Rac1 Efna5 Pak1 Epha1 Ngef Mmp2 Mmp9 Epha3 Epha2 Epha6 Wasl Epha7 Git1 Epha8 Ephb1 Ephb4 Grin2b Epha4 Epha5 Ephb6 Vav3 Rock1 Efnb2 Ephb3 Rock2 Cltb Adam10 Ap2m1 Actg1 Sdcbp Ap2a1 Yes1 Nck2 Lyn Ap2a2 Myl6 Myh11 Rasa1 Kdr Myh14 Ephb2 Myh10 Ap2s1 Dnm1 Tiam1 Limk1 Arhgef7 Arpc1a Sdc2 Actr2 Limk2 Actr3 Arpc1b Psen2 Kalrn Ncstn Vav2 Clta Pak3 Ap2b1 Pak2 Myl12b Myl12a Cltc Arpc3 Arpc2 Myh9 Itsn1 INTERACTION BETWEEN PHLDA1 AND AURKA%REACTOME DATABASE ID RELEASE 59%8854521 Interaction between PHLDA1 and AURKA Phlda1 Aurka APOPTOTIC FACTOR-MEDIATED RESPONSE%REACTOME%R-HSA-111471.2 Apoptotic factor-mediated response Casp3 Diablo Casp9 Casp7 Apaf1 Xiap INTRA-GOLGI AND RETROGRADE GOLGI-TO-ER TRAFFIC%REACTOME DATABASE ID RELEASE 59%6811442 Intra-Golgi and retrograde Golgi-to-ER traffic Zw10 Pla2g6 Rab1 Copa Klc3 Klc2 Klc4 Tmed3 Racgap1 Man2a1 Arcn1 Ykt6 Cenpe Kif2c Golga4 Cog6 Golga1 Cog3 Stx18 Kif2b Scoc Cog4 Vamp3 Kif18a Naa38 Cog2 Rab3gap1 Naa30 Naa35 Cog1 Arfip2 Rabepk Kif3c Tmf1 Nsf Arl1 Kif3b M6pr Kif3a Rab9 Kif2a Plin3 Tmed9 Igf2r Kif18b Man1c1 Bet1l Gcc1 Gbf1 Gcc2 Man1a Bicd2 Napb Bicd1 Napg Usp6nl Kifc5b Rab43 Klc1 Pafah1b3 Kifc2 Napa Pafah1b2 Vamp4 Rhobtb3 Dctn5 Dctn6 Cyth2 Kif16b Golim4 Kif26a Dctn1 Dctn4 Cyth1 Vti1a Stx6 Vps45 Golga5 Dync1li2 Cyth4 Kif26b Cyth3 Dync1li1 Alppl2 Kif13b Man1a2 Ric1 Rab1b Kif20b Vps54 Surf4 Kif4 Rab9b Arf5 Arfrp1 Kif20a Galnt1 Kdelr2 Galnt2 Kdelr3 Kifap3 Rab18 Rint1 Bnip1 Kif22 Rab6b Rab6a Vps52 Kif27 Cog7 Vps51 Use1 Kif23 Cog8 Vps53 Kif9 Pafah1b1 Arfgap3 Arfgap1 Arfgap2 Kif12 Copb2 Kif15 Stx5a Kif19a Kif6 Copb1 Rab36 Kif1c Snap29 Kif21a Copz1 Kif21b Rgp1 Rab30 Rab33b Kif1b Kif1a Trip11 Copz2 Stx16 Rab39 Copg1 Gosr1 Dynll2 Gosr2 Arf1 Kdelr1 Pla2g4a Arf3 Arf4 Kif11 Dync1i1 Dynll1 Cope Dync1i2 Sec22b Dctn2 Dctn3 Cux1 Dync1h1 Kif5a Kif5b Agpat3 VIRUS ASSEMBLY AND RELEASE%REACTOME%R-HSA-168268.2 Virus Assembly and Release Canx Calr IKBKB DEFICIENCY CAUSES SCID%REACTOME DATABASE ID RELEASE 59%5602636 IKBKB deficiency causes SCID Chuk Ikbkg BIOLOGICAL OXIDATIONS%REACTOME DATABASE ID RELEASE 59%211859 Biological oxidations Acsm2 Oplah Glyatl3 Ugdh Glyat Cyp21a1 Gstz1 Acsm5 Mat2a Nqo2 Cyp26c1 Gsta3 Cyp7a1 Trmt112 Ephx1 Cyp7b1 Dpep1 Dpep2 Aldh3a1 Nr1h4 Dpep3 Cyp3a16 Mat2b Gss Abhd10 Sult1a1 Cyp3a13 Ugt1a1 Abhd14b Cyp2r1 As3mt Nnmt Cyp2a5 Marc1 Marc2 Tbxas1 Aip Hpgds Cyp4a32 Cyp11b1 Acsm4 Cyp4f39 Cyp11b2 Sult1b1 Cyp51 Cyp2s1 Acsm1 Ahr Cyb5r3 Paox Cyp2j6 N6amt1 Ugt1a6a Cyp4a12b Maob Gstm5 Gclm Gstm7 Sult2a1 Ahcy Aldh1b1 Cyp27b1 Cyp1a2 Cndp2 Cyp26b1 Gclc Sult1e1 Ptgis Akr7a5 Ptgs1 Gstm2 Cyb5b Ggt6 Ggt7 Gstm4 Cyp1a1 Cyp2d22 Cyp2e1 Ugt2b38 Pomc Adh5 Arnt2 Ugt2b36 Adh7 Ugt2b34 Gstm1 Ggt5 Cyp17a1 Cyp24a1 Slc35d1 Cyp2w1 Cyp2f2 Cyp2c65 Chac2 Chac1 Cyp26a1 Rxra Cyp2b10 Acy3 Ugp2 Fmo1 Adh1 Fmo2 Adh4 Cyp1b1 Fmo3 Bpnt1 Ugt1a5 Gsto1 Ugt1a9 Gsto2 Gm10639 Acy1 Aldh2 Ugt1a2 Hsp90ab1 Akr1a1 Mat1a Ahrr Cyp4f40 Ugt3a2 Cyp2c50 Comt Cyp2c55 Bphl Maoa Esd Ces1d Tpmt Cyp2u1 Aadac Sult4a1 Mgst1 Ggt1 Mgst2 Mgst3 Cyp3a57 Gstt2 Gstt1 Cyp4f18 Cmbl Cyp4f17 Ugt2b1 Gstk1 Cyp4f15 Arnt Acss1 Cyp4b1 Cyp19a1 Cbr3 Ces2h Nat2 Aoc1 Nat1 Aoc2 Aoc3 Por Acss2 Cyp4f14 Ugt2a3 Ugt2a2 Ugt2a1 Fdx1 Fdx1l Ces3b Cyp11a1 Fdxr Cyp46a1 Cyp27a1 Slc35b2 Slc26a1 Cyp39a1 Slc26a2 Slc35b3 Papss2 Aldh1a1 Papss1 Cyp4v3 Cyp8b1 Mtrr Ncoa1 Mtr Ncoa2 TRANSLATION%REACTOME DATABASE ID RELEASE 59%72766 Translation Trmt112 Rps27 Tram1 Apeh Eef2 N6amt1 Rpn2 Sec61a2 Sec61g Sec61a1 Eif4b Sec61b Srp9 Rpn1 Srp54a Gspt1 Gspt2 Ssr2 Ssr3 Ssr4 Eef1b2 Eef1g Eef1d Eif4e Eef1a2 Eif4g1 Eif4ebp1 Rpl39 Rplp1 Eif2s1 Etf1 Eif2s2 Eif3i Eif3k Eif3l Eif3m Rpl7 Rps21 Rplp2 Eif3a Eif3b Eif3c Rps25 Rpl4 Eif3d Rps26 Rps27l Eif3e Rpl18a Rpl34 Rpl32 Srp72 Eif3f Eif3h Eif3g Rpl26 Ddost Rpl24 Rps9 Eif2s3x Rps7 Rps5 Srp68 Sec11c Sec11a Srp14 Spcs1 Rpsa Spcs2 Rpl37 Spcs3 Rps4x Srp19 Srprb Eif5 Eif5b Ssr1 Eif2b5 Eif2b4 Eif2b3 Eif2b2 Eif2b1 Srpr Eif4a1 Eif4a2 Rpl22 Eif1ax Rpl10l Rpl23 Rpl39l Eif3j2 Rpl13a Rpl22l1 Rps15a Rpl11 Rpl17 Rps3 Rpl19 Rpl18 Rps16 Rps14 Rps19 Rps18 Eif4h Pabpc1 Rps11 Rps10 DEFECTIVE CHSY1 CAUSES TPBS%REACTOME%R-HSA-3595177.1 Defective CHSY1 causes TPBS Bgn Dcn Bcan Ncan Vcan Cspg4 Cspg5 HCN CHANNELS%REACTOME DATABASE ID RELEASE 59%1296061 HCN channels Hcn4 Hcn3 Hcn1 Hcn2 TRANSFER OF LPS FROM LBP CARRIER TO CD14%REACTOME%R-HSA-166020.2 Transfer of LPS from LBP carrier to CD14 Lbp Cd14 RECOGNITION OF DNA DAMAGE BY PCNA-CONTAINING REPLICATION COMPLEX%REACTOME%R-HSA-110314.1 Recognition of DNA damage by PCNA-containing replication complex Ube2b Rbx1 Ube2a Pcna Ddb1 Dtl Zbtb32 Rfc5 Ubc Rfc3 Rfc2 Rfc4 Rfc1 Pole Pold1 Pold2 Pold3 Pold4 Pole2 Cul4a Rpa2 Rpa1 Rad18 Usp1 Rpa3 Pole4 Cul4b Pole3 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A%REACTOME%R-HSA-174184.2 Cdc20:Phospho-APC C mediated degradation of Cyclin A Psmc6 Psmc5 Psmc2 Psmd2 Psmb9 Psmf1 Psmb8 Psme4 Cdk1 Psmc1 Ccna1 Psmc4 Psmc3 Ccna2 Anapc15 Psme3 Anapc11 Anapc10 Bub1b Psmd12 Psma7 Psmd11 Psmd14 Psma5 Psmb5 Psmb4 Ubc Psmd13 Bub3 Psmd10 Psma4 Psmb7 Psma3 Psma6 Psmb6 Psmb2 Mad2l1 Psmb3 Psmb1 Psma2 Psma1 Cdc23 Psmd9 Ube2d1 Cdc27 Cdc16 Cdc20 Ube2c Anapc16 Ube2e1 Anapc7 Psmd1 Shfm1 Psme2 Anapc4 Anapc5 Psme1 Anapc1 Anapc2 Psmd3 Psmd4 Psmb10 Psmd6 Psmd5 Psmd7 Psmb11 Psmd8 TRANSLESION SYNTHESIS BY POLH%REACTOME%R-HSA-110320.1 Translesion Synthesis by POLH Ufd1l Vcp Rchy1 Polh Pcna Rfc5 Rpa2 Rpa1 Ubc Rfc3 Nploc4 Sprtn Rpa3 Rfc2 Rfc4 Rfc1 ALKBH2 MEDIATED REVERSAL OF ALKYLATION DAMAGE%REACTOME%R-HSA-112122.1 ALKBH2 mediated reversal of alkylation damage Alkbh2 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER%REACTOME%R-HSA-6782210.1 Gap-filling DNA repair synthesis and ligation in TC-NER Ppie Lig3 Pcna Ddb1 Ercc6 Polk Rfc5 Rfc3 Rfc2 Rfc4 Rfc1 Polr2f Polr2i Polr2e Polr2j Polr2h Pole Mnat1 Polr2c Polr2d Polr2b Pold1 Isy1 Pold2 Pold3 Pold4 Polr2g Polr2k Pole2 Rpa2 Cul4a Rpa1 Usp7 Ep300 Rpa3 Polr2a Lig1 Xab2 Gtf2h1 Pole4 Cul4b Gtf2h2 Pole3 Gtf2h5 Gtf2h4 Rbx1 Ercc8 Prpf19 Zfp830 Gtf2h3 Ercc3 Ubc Ercc2 Tcea1 Xrcc1 Aqr Uvssa Ccnh Cdk7 SIGNALING BY FGFR3 FUSIONS IN CANCER%REACTOME%R-HSA-8853334.1 Signaling by FGFR3 fusions in cancer Sos1 Gab1 Kras Frs2 Nras Pik3r1 Fgfr3 Hras Pik3ca LAGGING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 59%69186 Lagging Strand Synthesis Dna2 Pold1 Pold2 Pcna Pold3 Pold4 Prim1 Rfc5 Rpa2 Rpa1 Rfc3 Rpa3 Rfc2 Pola1 Pola2 Lig1 Rfc4 Fen1 Rfc1 Prim2 C-TYPE LECTIN RECEPTORS (CLRS)%REACTOME%R-HSA-5621481.1 C-type lectin receptors (CLRs) Prkcd Btrc Nfkb2 Nfkb1 Fbxw11 Map3k7 Cdc34 Tab1 Ppp3cb Tab2 Tab3 Card9 Pycard Pak1 Ppp3ca Clec7a Nfatc2 Ppp3r1 Nfatc1 Rela Nfatc3 Nfkbia Ep300 Casp8 Uba3 Psmd12 Map3k14 Psmd11 Relb Psmd14 Lyn Psmd13 Psmd10 Ube2m Il1b Rps6ka5 Ube2d1 Traf6 Kras Ikbkb Ube2v1 Ube2n Pak3 Shfm1 Pak2 Ikbkg Itpr1 Itpr3 Itpr2 Psmc6 Psmc5 Psmc2 Psmd2 Nras Prkacb Psmb9 Psmf1 Psmb8 Raf1 Hras Psme4 Malt1 Card11 Skp1a Psmc1 Psmc4 Psmc3 Cul1 Psme3 Fyn Plcg2 Bcl10 Syk Crebbp Clec4d Prkaca Muc1 Muc4 Cd209a Clec4e Icam2 Clec10a Muc15 Chuk Clec4a2 Fcer1g Clec4n Muc20 Clec4b2 Psma7 Muc13 Psma5 Psmb5 Psmb4 Ubc Psma4 Psma3 Psmb7 Psma6 Psmb6 Psmb2 Psmb3 Psma2 Psmb1 Psma1 Psmd9 Psmd1 Psme2 Psme1 Psmd3 Psmd4 Pdpk1 Psmb10 Psmd6 Psmd5 Ahcyl1 Psmd7 Psmb11 Psmd8 DEPOLYMERISATION OF THE NUCLEAR LAMINA%REACTOME%R-HSA-4419969.1 Depolymerisation of the Nuclear Lamina Emd Lpin2 Cdk1 Lpin3 Lmnb1 Lpin1 Lemd3 Prkcb Lemd2 Ctdnep1 Prkca Cnep1r1 REGULATION OF IFNG SIGNALING%REACTOME DATABASE ID RELEASE 59%877312 Regulation of IFNG signaling Ptpn1 Jak1 Pias1 Socs3 Ifngr1 Jak2 Socs1 Ptpn6 Ifngr2 Ifng Ptpn11 ERBB2 ACTIVATES PTK6 SIGNALING%REACTOME DATABASE ID RELEASE 59%8847993 ERBB2 Activates PTK6 Signaling Egf Egfr Nrg2 Ereg Nrg3 Hbegf Nrg4 Nrg1 Erbb2 Btc Ptk6 SODIUM PROTON EXCHANGERS%REACTOME%R-HSA-425986.1 Sodium Proton exchangers Slc9a5 Slc9a4 Slc9a3 Slc9a2 Slc9a9 Slc9a8 Slc9a7 Slc9a1 Slc9a6 TRANSPORT OF NUCLEOTIDE SUGARS%REACTOME DATABASE ID RELEASE 59%727802 Transport of nucleotide sugars Slc35d1 Slc35b2 Slc35c1 Slc35a2 Slc35d2 Slc35b4 Slc35a1 Slc35a3 Slc35b3 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 59%168179 Toll Like Receptor TLR1:TLR2 Cascade Ppp2r1a Btrc Mapk9 Nfkb2 Nfkb1 Ecsit Fbxw11 Skp1a Saa3 Ppp2r5d Mapkapk3 Tnip2 Myd88 Nod2 Cul1 Nod1 Dhx9 Vrk3 S100b Elk1 Mef2c Mapk10 Mef2a Sigirr Dusp3 Map3k7 Mapk7 Irak3 Peli1 Creb1 Mapkapk2 Irak2 Irak1 App Map2k6 Tab1 Tab2 Jun Mapk8 Tab3 Map3k1 Ripk2 Map2k7 Ager Map2k3 Map2k4 Map3k8 Rela Atf2 Nfkbia Peli3 Nfkbib Irak4 Fos Peli2 Ppp2cb Map2k1 Chuk Ppp2ca Btk Tlr2 Tlr6 Ubc Socs1 Mapk3 Rps6ka5 Mapk1 Ppp2r1b Dusp7 Rps6ka3 Dusp6 Rps6ka2 Rps6ka1 Traf6 Ikbkb Ube2v1 Tlr4 Ube2n Ly96 Cd14 Ikbkg Mapk11 Cd36 Mapk14 Tlr1 Tirap Dusp4 UNWINDING OF DNA%REACTOME%R-HSA-176974.2 Unwinding of DNA Mcm6 Mcm8 Gins1 Mcm7 Mcm3 Mcm2 Mcm5 Cdc45 Mcm4 Gins4 Gins2 Gins3 METABOLISM OF FAT-SOLUBLE VITAMINS%REACTOME%R-HSA-6806667.2 Metabolism of fat-soluble vitamins Agrn Akr1c6 Ldlr Lrp1 Bco1 Bco2 Akr1c18 Apoa4 Cyp2r1 Akr1c21 Apoa2 Apom Rdh11 Pnlip Apoa1 Apob Clps Lgmn Lrat Apoc2 Vkorc1 Apoc3 Cyp27b1 Vkorc1l1 Ubiad1 Gpihbp1 Ttr Lpl Apoe Sdc3 Rbp2 Sdc4 Cyp24a1 Rbp1 Gpc6 Sdc2 Gpc3 Sdc1 Akr1b10 Gpc5 Gpc2 Rbp4 Gpc4 Cubn Gc Lrp2 Plb1 Lrp12 Lrp10 Hspg2 Gpc1 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY%REACTOME%R-HSA-3359457.1 Defective GIF causes intrinsic factor deficiency Gif INTERCONVERSION OF 2-OXOGLUTARATE AND 2-HYDROXYGLUTARATE%REACTOME DATABASE ID RELEASE 59%880009 Interconversion of 2-oxoglutarate and 2-hydroxyglutarate Adhfe1 D2hgdh L2hgdh PRPP BIOSYNTHESIS%REACTOME%R-HSA-73843.2 PRPP biosynthesis Prps1l1 Prps2 Prps1 BASE-EXCISION REPAIR, AP SITE FORMATION%REACTOME DATABASE ID RELEASE 59%73929 Base-Excision Repair, AP Site Formation Nthl1 Ogg1 Neil1 Mpg Mbd4 Neil2 Smug1 Mutyh BUDDING AND MATURATION OF HIV VIRION%REACTOME DATABASE ID RELEASE 59%162588 Budding and maturation of HIV virion Chmp5 Chmp7 Chmp6 Chmp3 Vps37d Vps37c Vps37b Pdcd6ip Tonsl Vps4b Vps4a Vta1 Chmp2a Chmp4c Chmp4b Ubc Nedd4l Tsg101 Vps37a Ppia CELL CYCLE, MITOTIC%REACTOME%R-HSA-69278.1 Cell Cycle, Mitotic Prkcb Rfc5 Mcm6 Gins1 Rfc3 Mcm3 Mcm2 Mcm5 Mcm4 Rfc2 Gins4 Nipbl Rfc4 Mau2 Gins2 Rfc1 H2afj Gins3 H2afb2 Orc4 Orc5 Mcm8 Mcm7 Pole Cdt1 Cdc45 Dna2 Pold1 Pold2 Pold3 Pold4 Orc2 Orc3 Orc6 Orc1 Prim1 Pole2 Rpa2 Rpa1 Hist2h2be Rpa3 Pola1 Hist2h2ac Pola2 Lig1 Fen1 Pole4 H3f3b Prim2 H3f3a Pole3 Hist1h2bg Hist1h2bh Csnk2a2 Hist1h2bp Hist1h2bm Hist1h2bj Hist1h2bb Hist1h3d Csnk2b Hist1h2ak Hist1h2ag Hist1h2ah Nup50 Tpr Ndc1 Nup214 Hist2h3c1 Aaas Ppp1r12a Nup210 Nup188 Skp1a Nup54 Nup35 Rrm2 Nupl2 Nup62 Tyms Dhfr Nup205 Nup155 Cul1 Tk2 Nek6 Nup88 Pom121 Nek7 Nek9 Rae1 Tubg2 Gmnn Optn Numa1 E2f2 Ccnb2 Nup93 Phlda1 Gtse1 Cdc25b Nup153 Pkmyt1 E2f3 Cdk11b Tubgcp5 Tubgcp4 Tubgcp3 Tubgcp2 Hmmr Ajuba Foxm1 Fbxl7 Fkbpl Fbxl18 Bora Prkca Ccne1 Lin37 Lin54 Ccne2 Hdac1 Mnat1 Rbx1 Cdkn1a Tpx2 Psmd12 Psmd11 Psmd14 Psmd13 Setd8 Psmd10 Cdc23 Ppp2r1b Ube2d1 Cdc27 Cdc14a Cdc16 Cdc20 Ube2c Anapc16 Ube2e1 Anapc7 Shfm1 Anapc4 Anapc5 Anapc1 Anapc2 Pafah1b1 Psmc6 Psmc5 Ccp110 Nek2 Cep57 Psmc2 Haus7 Psmd2 Haus8 Ywhag Psmb9 Hsp90aa1 Psmb8 Ywhaq Rab8a B9d2 Prkar2b Ppp2r5e Haus3 Haus4 Cdk1 Ppp2r5c Cetn2 Ppp2r5d Ppp2r5a Psmc1 Ofd1 Haus2 Psmc4 Psmc3 Cep63 Anapc15 Alms1 Haus5 Anapc11 Haus6 Anapc10 Haus1 Fzr1 Tubb4a Tubb4b Clasp1 Ssna1 Tubg1 Csnk1d Cep250 Tuba4a Dynll1 Ppp2r5b Csnk1e Cep135 Cdk5rap2 Mapre1 Pcnt Sfi1 Cep70 Nedd1 Actr1a Cdkn1b Hist3h2ba Cep131 Pcm1 Prkaca Dync1i2 Fgfr1op Cep76 Cep78 Cep72 Dctn2 Dctn3 Wee1 Ckap5 Cep164 Cdc25c Tubb5 Tuba1a Cep41 Plk1 Cenpj Dync1h1 Psma5 Plk4 Sdccag8 Ppp1cb Psma4 Psma3 Psma6 Cdc7 H2afz Dbf4 H2afx Psma2 Mcm10 Psma1 Psmd9 Hist2h2aa1 Psmd1 Psmd3 Psmd4 Ccnh Psmd6 Psmd5 Psmd7 Psmd8 Zw10 Ska1 Ankle2 Nup85 Pmf1 Nup160 Vrk1 Akap9 Spc25 Nudc Ppp2r1a Rps27 Ywhae Spc24 Xpo1 Clasp2 Ninl Itgb3bp Cep152 Nuf2 Btrc Fbxw11 Cenpf Ppp1cc Cenpq Cenpp Ahctf1 Fbxo5 Cenpm Cenpl Cenpo Clip1 Cenpn Aurkb Zwilch Cdca8 Cenpt Aurka Apitd1 Stag2 Sgol2b Ercc6l Stag1 Ppp2r2a Banf1 Dsn1 Ep300 Nup107 Mad1l1 Pttg1 Smc1a Rad21 Cenph Cenpi Cenpe Cenpk Kif2c Taok1 Birc5 Kif2b Kif18a Bub1b Zwint Nup37 Incenp Wapal Nup43 Nup133 Rcc2 Nsl1 Kif2a Ndel1 Spdl1 Ndc80 Emd Kntc1 Bub3 Cdca5 Bub1 Cenpu Mad2l1 Casc5 Smc3 Cenpa Espl1 Lemd3 Lemd2 Cenpc1 Sgol1 Pds5a Ranbp2 Mis12 Pds5b Dyrk1a Pcna Lin9 Psmf1 Psme4 Rbl2 Rbl1 Mybl2 Cdc6 Cdk2 E2f5 E2f4 E2f1 Ccna1 Rbbp4 Skp2 Cdc25a Ccna2 Psme3 Cdk4 Tfdp2 Cks1b Lin52 Max Tfdp1 Top2a Ccnd1 Ppp2cb Ppp2ca Akt2 Akt3 Psma7 Psmb5 Psmb4 Ubc Myc Psmb7 Psmb6 Cdkn2a Psmb2 Psmb3 Psmb1 Cdkn2b Akt1 Mapk1 Trp53 Psme2 Psme1 Hist1h3h Psmb10 Cdk7 Psmb11 Lmnb1 Rb1 Rab2a Cdkn2c Ncaph Arpp19 Mastl Ppp2r2d Mcph1 Ccnd2 Gorasp2 Cdkn1c Ensa Esco2 Esco1 Blzf1 Ptk6 Cdk6 Rab1 Smc4 Ncaph2 Ccnd3 Smc2 Ncapg2 Ncapd2 Ncapd3 Sec13 Gorasp1 Ctdnep1 Cnep1r1 Rab1b Kif20a Uso1 Hsp90ab1 Kif23 Golga2 Lpin2 Lpin3 Lpin1 INLB-MEDIATED ENTRY OF LISTERIA MONOCYTOGENES INTO HOST CELL%REACTOME%R-HSA-8875360.1 InlB-mediated entry of Listeria monocytogenes into host cell Ubc Cbl Sh3gl2 Sh3gl1 Stam Hgs Met Sh3kbp1 Stam2 Eps15 PKA-MEDIATED PHOSPHORYLATION OF KEY METABOLIC FACTORS%REACTOME DATABASE ID RELEASE 59%163358 PKA-mediated phosphorylation of key metabolic factors Prkaca Prkacb Mlxipl Pfkfb1 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS%REACTOME%R-HSA-163125.2 Post-translational modification: synthesis of GPI-anchored proteins Xpnpep2 Spaca4 Lsamp Negr1 Mdga2 Pigw Msln Ntm Alpi Ly6k Sprn Nrn1 Izumo1r Psca Dpm1 Tex101 Bst1 Dpm2 Dpm3 Gpld1 Prnd Opcml Lypd4 Lypd3 Lypd2 Cntn3 Pigv Mdga1 Pigx Otoa Pign Pigo Ly6g6d Cpm Ly6e Ly6d Ly6g6c Pigs Ly6h Pigu Plaur Pigt Pigc Tecta Prss41 Pigb Pigf Pigg Nrn1l Pigh Thy1 Reck Ntng1 Gpihbp1 Rtn4rl1 Cd109 Rtn4rl2 Gp2 Piga Tectb Art4 Art3 Lypd5 Alpl Lypd8 Lypd1 Lypd6b Pigk Pigm Pigl Prss21 Pgap1 Gpaa1 Mfi2 Cntn5 Folr2 Alppl2 Vnn3 Vnn1 AFLATOXIN ACTIVATION AND DETOXIFICATION%REACTOME DATABASE ID RELEASE 59%5423646 Aflatoxin activation and detoxification Mgst1 Ggt1 Mgst2 Mgst3 Dpep1 Acy3 Dpep2 Cyp1a2 Dpep3 Cyp3a16 Akr7a5 Ggt6 Ggt7 Acy1 Cyp2a5 Ggt5 FCERI MEDIATED CA+2 MOBILIZATION%REACTOME%R-HSA-2871809.1 FCERI mediated Ca+2 mobilization Ppp3cb Plcg2 Btk Ppp3ca Vav2 Nfatc2 Syk Ppp3r1 Nfatc1 Plcg1 Nfatc3 Itpr1 Sos1 Vav1 Lyn Txk Ahcyl1 Itpr3 Tec Vav3 Grap2 Itk Itpr2 Lcp2 CELL-CELL JUNCTION ORGANIZATION%REACTOME%R-HSA-421270.3 Cell-cell junction organization Cldn6 Cldn9 Cldn3 Cldn4 Cldn5 Ctnna1 Cadm2 Cadm1 F11r Pard3 Crb3 Cdh24 Prkci Pard6b Pard6a Pard6g Cadm3 Jup Ctnnd1 Cdh1 Cdh2 Cdh3 Cldn2 Cldn1 Cdh4 Cdh5 Cdh6 Cdh8 Cdh7 Cdh9 Cldn23 Cldn22 Cldn20 Ang Inadl Cldn19 Cldn17 Pvrl4 Cldn18 Pvrl1 Pvrl2 Cldn16 Cldn10 Cldn15 Pvrl3 Cldn11 Cldn14 Cldn12 Cdh17 Cdh10 Cdh13 Cdh12 Cdh15 Mpp5 Cdh11 Cldn8 Cldn7 REGULATION OF IFNA SIGNALING%REACTOME%R-HSA-912694.1 Regulation of IFNA signaling Ptpn1 Jak1 Socs3 Usp18 Ifnar1 Stat2 Socs1 Ptpn6 Ptpn11 Ifnb1 Ifna16 Tyk2 TANDEM OF PORE DOMAIN IN A WEAK INWARDLY RECTIFYING K+ CHANNELS (TWIK)%REACTOME%R-HSA-1299308.1 Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK) Kcnk7 Kcnk6 Kcnk1 SIGNALING BY PTK6%REACTOME%R-HSA-8848021.2 Signaling by PTK6 Egf Dock1 Nf1 Nras Dab2ip Hras Khdrbs2 Gpnmb Ccne1 Khdrbs1 Egfr Khdrbs3 Cdk2 Rhoa Lrrk2 Erbb2 Nr3c1 Cdk4 Elmo1 Stap2 Elmo2 Dok1 Hif1a Arhgap35 Ccnd1 Sfpq Ptk6 Pelp1 Rac1 Epas1 Cdkn1b Ptpn1 Srms Nrg2 Ereg Nrg1 Arap1 Stat3 Rasa3 Rasal3 Rasa4 Pxn Rasal2 Ubc Socs3 Cbl Nrg3 Rasa2 Nrg4 Rasa1 Spred3 Spred2 Akt1 Spred1 Kras Bcar1 Rasal1 Syngap1 Hbegf Crk Btc REMOVAL OF THE FLAP INTERMEDIATE%REACTOME%R-HSA-69166.2 Removal of the Flap Intermediate Dna2 Pold1 Pold2 Pold3 Pcna Pold4 Prim1 Rpa2 Rpa1 Rpa3 Pola1 Pola2 Fen1 Prim2 RESOLUTION OF D-LOOP STRUCTURES THROUGH HOLLIDAY JUNCTION INTERMEDIATES%REACTOME DATABASE ID RELEASE 59%5693568 Resolution of D-loop Structures through Holliday Junction Intermediates Rbbp8 Blm Eme1 Rad50 Rad51b Rad51c Gen1 Exo1 Brip1 Rad51 Spidr Nbn Rad51ap1 Dna2 Kat5 Wrn Slx4 Bard1 Mus81 Brca1 Palb2 Mre11a Xrcc3 Rad51d Atm Xrcc2 Top3a Brca2 TP53 REGULATES TRANSCRIPTION OF CASPASE ACTIVATORS AND CASPASES%REACTOME DATABASE ID RELEASE 59%6803207 TP53 Regulates Transcription of Caspase Activators and Caspases Pidd1 Atm Apaf1 Trp53 Cradd Trp73 Trp63 Casp6 Casp1 Nlrc4 Casp2 SYNTHESIS OF PA%REACTOME%R-HSA-1483166.4 Synthesis of PA Acp6 Pla2g5 Pla2g4d Gpd1 Pla2g2e Pla2g12a Agpat6 Pla2g2d Agpat5 Pla2g1b Pla2g2f Lclat1 Gnpat Lpcat4 Pla2g4a Pla2g10 Pla2r1 Alpi Lpcat1 Gpam Agpat3 Agpat4 Agpat1 Agpat2 Agpat9 Ddhd1 Pld2 Pld1 Gpd1l Gpat2 DEGRADATION OF THE EXTRACELLULAR MATRIX%REACTOME%R-HSA-1474228.4 Degradation of the extracellular matrix Phykpl Plg Mmp2 Mmp9 Col17a1 Lama3 Capn15 Capn7 Lamc1 Capn5 Capn8 Dcn Capn9 Col16a1 Timp1 Col15a1 Bcan Psen1 Col9a1 Col9a2 Col9a3 Casp3 Lamb1 Ctrb1 Prss2 Mmp13 Mmp14 Adamts4 Adamts1 Mmp17 Mmp15 Mmp11 Mmp12 Mmp16 Adam9 Cma1 Adamts8 Col26a1 Elane Mmp10 Adam8 Tmprss6 Mmp20 Mmp25 Mmp24 Adamts18 Col12a1 Adamts16 Col13a1 Capn11 Capn13 Capn10 Col14a1 Capn6 Adam15 Capn3 Col18a1 Capn1 Cast Capns1 Capn2 Capns2 Spp1 Furin A2m Bsg Adam10 Cdh1 Tll1 Lama5 Mmp1a Optc Col25a1 Nid1 Timp2 Tll2 Ctss Col23a1 Lamb3 Klk7 Ctsg Ctsb Bmp1 Ncstn Ctsk Ctsl Mmp19 Adamts5 Ctsd Klkb1 Mmp3 Htra1 Adam17 Tpsb2 Cd44 Col19a1 Spock3 Lamc2 Hspg2 Mmp8 Mmp7 ROS, RNS PRODUCTION IN PHAGOCYTES%REACTOME%R-HSA-1222556.6 ROS, RNS production in phagocytes Nos3 Ncf4 Ncf2 Atp6v0d2 Ncf1 Atp6v0d1 Atp6v0b Atp6v1c2 Atp6v1c1 Atp6v0e Atp6v1g3 Atp6v1e2 Atp6v1e1 Atp6v0e2 Cybb Atp6v1a Cyba Atp6v1b1 Tcirg1 Atp6v1b2 Atp6v1g1 Atp6v1g2 Atp6v0a1 Atp6v0a2 Atp6v1h Atp6v0a4 Slc11a1 Nos1 Atp6v1d Atp6v1f Nos2 M PHASE%REACTOME DATABASE ID RELEASE 59%68886 M Phase Zw10 Ska1 Ankle2 Nup85 Pmf1 Nup160 Vrk1 Spc25 Nudc Ppp2r1a Rps27 Spc24 Xpo1 Clasp2 Prkcb Itgb3bp Nuf2 Nipbl Mau2 H2afj Cenpf H2afb2 Ppp1cc Cenpq Cenpp Ahctf1 Fbxo5 Cenpm Cenpl Cenpo Clip1 Cenpn Aurkb Zwilch Cdca8 Cenpt Apitd1 Stag2 Sgol2b Ercc6l Stag1 Ppp2r2a Banf1 Hist2h2be Dsn1 Nup107 Mad1l1 Pttg1 Smc1a Hist2h2ac Rad21 Cenph H3f3b Cenpi H3f3a Cenpe Cenpk Hist1h2bg Kif2c Taok1 Hist1h2bh Birc5 Kif2b Kif18a Bub1b Csnk2a2 Zwint Nup37 Hist1h2bp Incenp Wapal Hist1h2bm Nup43 Nup133 Rcc2 Hist1h2bj Nsl1 Hist1h2bb Kif2a Ndel1 Spdl1 Ndc80 Emd Kntc1 Bub3 Cdca5 Bub1 Cenpu Mad2l1 Casc5 Smc3 Cenpa Espl1 Lemd3 Lemd2 Cenpc1 Hist1h3d Csnk2b Sgol1 Hist1h2ak Pds5a Ranbp2 Mis12 Hist1h2ag Pds5b Hist1h2ah Nup50 Tpr Psmf1 Psme4 Ndc1 Nup214 Hist2h3c1 Aaas Nup210 Nup188 Nup54 Nup35 Nupl2 Nup62 Nup205 Nup155 Psme3 Nup88 Nek6 Nek7 Pom121 Rae1 Nek9 Ccnb2 Nup93 Nup153 Ppp2cb Ppp2ca Psma7 Psmb5 Psmb4 Ubc Psmb7 Psmb6 Psmb2 Psmb3 Psmb1 Mapk1 Psme2 Hist1h3h Psme1 Psmb10 Psmb11 Lmnb1 Prkca Rb1 Rab2a Ncaph Arpp19 Mastl Ppp2r2d Mcph1 Gorasp2 Ensa Blzf1 Rab1 Smc4 Ncaph2 Smc2 Ncapg2 Ncapd2 Ncapd3 Sec13 Psmd12 Gorasp1 Psmd11 Psmd14 Psmd13 Psmd10 Setd8 Ctdnep1 Cnep1r1 Cdc23 Ppp2r1b Ube2d1 Cdc27 Cdc16 Cdc20 Ube2c Anapc16 Ube2e1 Anapc7 Shfm1 Anapc4 Anapc5 Anapc1 Anapc2 Rab1b Kif20a Uso1 Kif23 Pafah1b1 Psmc6 Psmc5 Psmc2 Psmd2 Psmb9 Psmb8 B9d2 Ppp2r5e Cdk1 Ppp2r5c Golga2 Ppp2r5d Ppp2r5a Psmc1 Psmc4 Psmc3 Anapc15 Anapc11 Anapc10 Lpin2 Clasp1 Ppp2r5b Mapre1 Hist3h2ba Lpin3 Lpin1 Ckap5 Plk1 Psma5 Psma4 Psma3 Psma6 H2afz H2afx Psma2 Psma1 Psmd9 Hist2h2aa1 Psmd1 Psmd3 Psmd4 Psmd6 Psmd5 Psmd7 Psmd8 NA+-DEPENDENT GLUCOSE TRANSPORTERS%REACTOME%R-HSA-428808.1 Na+-dependent glucose transporters Slc5a2 Slc5a3 Slc5a1 2010001E11Rik Slc5a9 Slc5a4a OPIOID SIGNALLING%REACTOME%R-HSA-111885.1 Opioid Signalling Adcy7 Gngt1 Gng7 Adcy6 Adcy5 Prkcd Gng4 Adcy4 Adcy3 Pde4d Pde4c Adcy2 Gngt2 Prkcg Prkar2a Adcy1 Ppp2r1a Prkacb Gng10 Adcy9 Gnaz Adcy8 Prkca Prkar2b Ppp2r5d Adrbk1 Pla2g4a Gnai2 Creb1 Gnai1 Ppp3cb Gnai3 Ppp3ca Camk4 Gnal Ppp3r1 Gng11 Gng13 Gng12 Gnb2 Gnb1 Gnb3 Prkar1a Gnb5 Prkar1b Gnb4 Prkaca Gng8 Gng3 Gng2 Ppp2cb Ppp3cc Ppp1r1b Ppp2ca Plcb1 Plcb2 Pomc Pdyn Mapk1 Ppp2r1b Gnat1 Gnat2 Pde1c Gnat3 Pde1b Gnao1 Pde1a Pde4a Pde4b Itpr1 Ppp1ca Plcb4 Plcb3 Ahcyl1 Itpr3 Cdk5 Itpr2 Oprm1 ANDROGEN BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 59%193048 Androgen biosynthesis Cyp17a1 Lhb Hsd17b12 Pomc Srd5a2 Hsd3b1 Hsd3b6 Srd5a1 Hsd17b3 Srd5a3 Cga SIGNAL AMPLIFICATION%REACTOME%R-HSA-392518.1 Signal amplification Gngt1 Gng7 Tbxa2r Gng4 Gngt2 P2ry12 Gng10 Pla2g4a Gnai2 P2ry1 Gnai1 Gnai3 Gnat3 Gng11 Gng13 Gng12 Gnb2 Mapk14 Gnb1 Gnb3 Gnb5 Gnb4 Gna11 Gng8 Gnaq Gna15 Gng3 Gng2 Gna13 Gna14 RHO GTPASES ACTIVATE PAKS%REACTOME%R-HSA-5627123.1 RHO GTPases activate PAKs Limk1 Cttn Nf2 Rac1 Pak1 Mylk Pak3 Pak2 Flna Myl12b Myl12a Myl6 Ppp1r12a Myh11 Ppp1cb Ppp1r12b Myh14 Myh9 Myh10 MITOCHONDRIAL ABC TRANSPORTERS%REACTOME DATABASE ID RELEASE 59%1369007 Mitochondrial ABC transporters Abcb6 Abcb10 Abcb8 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME%R-HSA-975871.1 MyD88 cascade initiated on plasma membrane Ppp2r1a Btrc Mapk9 Nfkb2 Nfkb1 Ecsit Fbxw11 Skp1a Saa3 Ppp2r5d Mapkapk3 Tnip2 Myd88 Nod2 Cul1 Nod1 Dhx9 Vrk3 S100b Elk1 Mef2c Mapk10 Mef2a Tlr5 Map3k7 Dusp3 Mapk7 Peli1 Creb1 Mapkapk2 Irak2 Irak1 App Map2k6 Tab1 Tab2 Jun Mapk8 Tab3 Map3k1 Ripk2 Map2k7 Ager Map2k3 Map2k4 Map3k8 Atf2 Rela Nfkbia Peli3 Nfkbib Irak4 Fos Peli2 Ppp2cb Map2k1 Chuk Ppp2ca Ubc Mapk3 Rps6ka5 Mapk1 Ppp2r1b Dusp7 Rps6ka3 Dusp6 Rps6ka2 Rps6ka1 Traf6 Ikbkb Ube2v1 Ube2n Ikbkg Mapk11 Mapk14 Dusp4 CYTOSOLIC SULFONATION OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 59%156584 Cytosolic sulfonation of small molecules Sult4a1 Sult2a1 Sult1e1 Sult1a1 Bpnt1 Slc35b2 Abhd14b Slc26a1 Slc26a2 Slc35b3 Papss2 Papss1 Sult1b1 C6 DEAMINATION OF ADENOSINE%REACTOME DATABASE ID RELEASE 59%75102 C6 deamination of adenosine Adarb1 Adar SIGNALLING TO RAS%REACTOME DATABASE ID RELEASE 59%167044 Signalling to RAS Akap9 Ppp2r1a Mapkapk3 Csf2 Jak1 Frs2 Nras Frs3 Rasgrf1 Psmf1 Raf1 Psme4 Il5ra Fgf1 Il17rd Fgf2 Cnksr1 Csk Cnksr2 Erbb2 Fgf9 Ptk2 Fgf7 Psme3 Fgf6 Fgf4 Fgf3 Ppp5c Ranbp9 Ppp2cb Shc1 Lamtor2 Nrg2 Ppp2ca Shc3 Nrg1 Shc2 Psma7 Artn Nrtn Brap Psmb5 Psmb4 Ubc Nrg3 Psmb7 Nrg4 Psmb6 Psmb2 Psmb3 Psmb1 Mapk3 Mapk1 Ksr1 Ptpra Dusp16 Dusp10 Map3k11 Paqr3 Psme2 Psme1 Ncam1 Sos1 Braf Psmb10 Apbb1ip Psmb11 Csf2rb2 Rapgef2 Csf2ra Actn2 Nf1 Pdgfrb Pdgfra Kbtbd7 Il2rg Arrb2 Egfr Arrb1 Ret Ntrk1 Vwf Ralb Rala Mapkapk2 Sptan1 Pspn Map2k1 Rbx1 Fgg Map2k2 Cul3 Psmd12 Pdgfb Psmd11 Rasgef1a Psmd14 Rasa3 Rasa4 Psmd13 Psmd10 Il2 Rasa2 Rasa1 Nefl Spred3 Kit Spred2 Grin2a Spred1 Spta1 Il5 Ppp2r1b Sptbn4 Ywhab Kras Gdnf Shfm1 Irs2 Syngap1 Hbegf Irs1 Il3ra Btc Il2ra Il2rb Angpt1 Psmc6 Egf Fgf23 Psmc5 Fgf22 Mark3 Psmc2 Fgf20 Psmd2 Dab2ip Tek Psmb9 Psmb8 Araf Hras Grin1 Ppp2r5e Dlg4 Ppp2r5c Ppp2r5d Ppp2r5a Psmc1 Psmc4 Psmc3 Sptbn2 Itgb3 Sptbn1 Fyn Phb Grin2c Rasgrp4 Rasgrp3 Pebp1 Ppp2r5b Rasgrp1 Tln1 Fga Fgb Grin2d Grin2b Sptb Hgf Gfra2 Gfra3 Gfra4 Ereg Jak2 Pea15a Itga2b Rap1a Jak3 Wdr83 Camk2d Rap1b Camk2a Fgfr4 Camk2b Psma5 Rasal3 Rasal2 Psma4 Psma3 Psma6 Vcl Camk2g Psma2 Psma1 Gfra1 Psmd9 Ngf Dusp7 Iqgap1 Fgf16 Dusp6 Ralgds Dusp9 Fgf15 Dusp8 Klb Fgf18 Psmd1 Met Fn1 Mapk11 Rasal1 Dusp1 Mapk13 Psmd3 Mapk12 Psmd4 Mapk14 Psmd6 Psmd5 Dusp2 Psmd7 Dusp5 Psmd8 Fgf10 Dusp4 ENOS ACTIVATION AND REGULATION%REACTOME%R-HSA-203765.1 eNOS activation and regulation Cygb Gchfr Prkg2 Pts Nos3 Nostrin Cav1 Hsp90aa1 Wasl Lypla1 Dnm2 Zdhhc21 Ddah2 Dhfr Ddah1 Spr Gch1 Nosip Akt1 POLB-DEPENDENT LONG PATCH BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 59%110362 POLB-Dependent Long Patch Base Excision Repair Parp1 Parg Apex1 Parp2 Lig1 Fen1 Polb OLIGOMERIZATION OF CONNEXINS INTO CONNEXONS%REACTOME%R-HSA-190704.1 Oligomerization of connexins into connexons Gjb1 Gjb2 Gja1 METABOLISM OF NITRIC OXIDE%REACTOME DATABASE ID RELEASE 59%202131 Metabolism of nitric oxide Cygb Gchfr Prkg2 Pts Nos3 Nostrin Cav1 Hsp90aa1 Wasl Lypla1 Dnm2 Zdhhc21 Ddah2 Dhfr Ddah1 Spr Gch1 Nosip Akt1 TRAFFICKING OF DIETARY STEROLS%REACTOME%R-HSA-265473.1 Trafficking of dietary sterols Abcg5 Abcg8 PTK6 EXPRESSION%REACTOME%R-HSA-8849473.1 PTK6 Expression Pelp1 Epas1 Nr3c1 Hif1a Ptk6 SYNTHESIS OF PI%REACTOME DATABASE ID RELEASE 59%1483226 Synthesis of PI Cdipt Cds1 Pitpnm2 Pitpnm1 Pitpnm3 RNA POLYMERASE II PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 59%73776 RNA Polymerase II Promoter Escape Gtf2h5 Gtf2a1 Taf13 Gtf2h4 Taf11 Gtf2a2 Gtf2b Gtf2h3 Ercc3 Taf1 Taf2 Taf4b Taf7 Taf4a Taf12 Taf5 Taf6 Taf3 Ercc2 Polr2i Polr2f Polr2j Polr2e Gtf2e1 Polr2h Tbp Gtf2e2 Polr2c Mnat1 Polr2d Ak6 Polr2b Taf9b Taf9 Polr2k Polr2g Ccnh Cdk7 Polr2a Gtf2h1 Gtf2f1 Gtf2h2 Gtf2f2 SIGNAL TRANSDUCTION BY L1%REACTOME%R-HSA-445144.1 Signal transduction by L1 Map2k1 Itgb1 Nrp1 Csnk2a2 Rac1 Itga2b Map2k2 Pak1 L1cam Vav2 Csnk2b Ncam1 Egfr Itgav Itga9 Mapk3 Itga5 Mapk1 Itgb3 NON-CODING RNA METABOLISM%REACTOME%R-HSA-194441.1 Non-coding RNA Metabolism Nup85 Nup160 Nup37 Nup50 Gemin5 Gemin4 Nup43 Tpr Gemin7 Nup133 Ndc1 Smn1 Gemin2 Nup214 Aaas Nup210 Nup188 Nup54 Nup35 Prmt5 Nupl2 Snrpd2 Nup62 Nup205 Nup155 Snrpd1 Wdr77 Nup88 Pom121 Snrpb Snrpd3 Rae1 Nup93 Nup153 Phax Snupn Clns1a Ranbp2 Nup107 Ddx20 Ncbp1 Ncbp2 SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE%REACTOME DATABASE ID RELEASE 59%1660517 Synthesis of PIPs at the late endosome membrane Mtmr7 Pik3c3 Mtmr4 Pik3c2a Pikfyve Fig4 Mtmr2 Pik3r4 Mtm1 Vac14 NADPH REGENERATION%REACTOME%R-HSA-389542.1 NADPH regeneration Idh1 TANDEM PORE DOMAIN HALOTHANE-INHIBITED K+ CHANNEL (THIK)%REACTOME%R-HSA-1299287.1 Tandem pore domain halothane-inhibited K+ channel (THIK) Kcnk13 FGFRL1 MODULATION OF FGFR1 SIGNALING%REACTOME%R-HSA-5658623.3 FGFRL1 modulation of FGFR1 signaling Fgf23 Fgfrl1 Fgf22 Fgf2 Fgf18 Spred2 Fgf10 Fgf4 Spred1 Fgf3 PORPHYRIN METABOLISM%REACTOME DATABASE ID RELEASE 59%189445 Porphyrin metabolism Alad Hmox1 Blvrb Blvra Hmox2 Ugt1a5 Hmbs Ugt1a1 Fech Alas1 Alas2 Uros Ppox Cox15 Urod Cox10 Cpox LEADING STRAND SYNTHESIS%REACTOME%R-HSA-69109.3 Leading Strand Synthesis Pold1 Pold2 Pold3 Pcna Pold4 Prim1 Rfc5 Rfc3 Rfc2 Pola1 Pola2 Rfc4 Prim2 Rfc1 RHO GTPASES REGULATE CFTR TRAFFICKING%REACTOME DATABASE ID RELEASE 59%5627083 RHO GTPases regulate CFTR trafficking Gopc Cftr Rhoq RRNA PROCESSING%REACTOME DATABASE ID RELEASE 59%72312 rRNA processing Nhp2 Bysl Rpp21 Rpp25 Trmt112 Rrp36 Rps27 Elac2 Trmt10c Pdcd11 Mterf4 Riok2 Riok1 Krr1 Nsun4 Pwp2 Riok3 Heatr1 Pno1 Mrm1 Pelp1 Utp18 Exosc9 Exosc8 Utp11l Mphosph10 Exosc7 Utp15 Exosc5 Exosc4 Diexf Pes1 Dcaf13 Wbscr22 Cirh1a Nop56 Utp14a Tex10 Dimt1 Nol9 Nol6 Utp3 Eri1 Exosc3 Utp6 Exosc1 Nop58 Exosc2 Isg20l2 Xrn2 Bms1 Mphosph6 Ltv1 Ftsj2 Utp20 Dhx37 Nop10 Bop1 Wdr75 Nop14 Nat10 1110008L16Rik Rnmtl1 Thumpd1 Nob1 Tbl3 Tsr1 Fbl Tsr3 Wdr3 Wdr12 Senp3 Wdr18 Wdr43 Wdr46 Emg1 Dkc1 Rpl39 Rplp1 Ddx52 Rpl7 Rps21 Noc4l Rplp2 Las1l Ddx49 Rps25 Ddx47 Rpl4 Rps26 Rps27l Rpl18a Rpl34 Rpl32 C1d Rpl26 Rpl24 Rps9 Rps7 Rps5 Imp4 Imp3 Csnk1d Nol11 Csnk1e Rrp9 Rpsa Rpl37 Rps4x Exosc10 Tfb1m Rpp14 Nop2 Rcl1 Gar1 Rpl22 Rpp30 Rpp38 Rpl10l Rpl23 Rpl39l Rpl13a Rpl22l1 Rps15a Rpl11 Rpl17 Rps3 Hsd17b10 Rpl19 Rpl18 Rpp40 Rps16 Rps14 Rps19 Rps18 Skiv2l2 Rps11 Rps10 MITOCHONDRIAL TRANSCRIPTION INITIATION%REACTOME%R-HSA-163282.2 Mitochondrial transcription initiation Polrmt Tfam Tfb2m TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR%REACTOME DATABASE ID RELEASE 59%1679131 Trafficking and processing of endosomal TLR Hsp90b1 Lgmn Tlr9 Cnpy3 Ctss Tlr8 Tlr7 Unc93b1 Ctsb Ctsk Tlr3 Ctsl LOCALIZATION OF THE PINCH-ILK-PARVIN COMPLEX TO FOCAL ADHESIONS%REACTOME DATABASE ID RELEASE 59%446343 Localization of the PINCH-ILK-PARVIN complex to focal adhesions Itgb1 Pxn Ilk Parva AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS%REACTOME DATABASE ID RELEASE 59%198693 AKT phosphorylates targets in the nucleus Creb1 Rps6kb2 Akt2 Akt3 Nr4a1 Foxo3 Akt1 Foxo1 APC:CDC20 MEDIATED DEGRADATION OF CELL CYCLE PROTEINS PRIOR TO SATISFATION OF THE CELL CYCLE CHECKPOINT%REACTOME DATABASE ID RELEASE 59%179419 APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint Psmc6 Psmc5 Nek2 Psmc2 Psmd2 Psmb9 Psmf1 Psmb8 Psme4 Cdk1 Psmc1 Ccna1 Psmc4 Psmc3 Ccna2 Anapc15 Psme3 Anapc11 Anapc10 Bub1b Psmd12 Psma7 Psmd11 Psmd14 Psma5 Psmb5 Psmb4 Ubc Psmd13 Bub3 Psmd10 Psma4 Psmb7 Psma3 Psma6 Psmb6 Psmb2 Mad2l1 Psmb3 Psmb1 Psma2 Psma1 Cdc23 Psmd9 Ube2d1 Cdc27 Cdc16 Cdc20 Ube2c Anapc16 Ube2e1 Anapc7 Psmd1 Shfm1 Psme2 Anapc4 Anapc5 Psme1 Anapc1 Anapc2 Psmd3 Psmd4 Psmb10 Psmd6 Psmd5 Psmd7 Psmb11 Psmd8 VPR-MEDIATED NUCLEAR IMPORT OF PICS%REACTOME%R-HSA-180910.2 Vpr-mediated nuclear import of PICs Nup85 Nup160 Nup37 Nup50 Hmga1 Tpr Nup43 Nup133 Ndc1 Nup214 Aaas Nup210 Nup188 Nup54 Nup35 Nupl2 Nup62 Nup205 Nup155 Nup88 Pom121 Rae1 Nup93 Nup153 Kpna1 Psip1 Ranbp2 Banf1 Nup107 DISEASES ASSOCIATED WITH SURFACTANT METABOLISM%REACTOME%R-HSA-5687613.1 Diseases associated with surfactant metabolism Ccdc59 Ttf1 Sftpb Sftpc Csf2rb2 Sftpa1 Sftpd Csf2ra FORMATION OF HIV ELONGATION COMPLEX IN THE ABSENCE OF HIV TAT%REACTOME%R-HSA-167152.2 Formation of HIV elongation complex in the absence of HIV Tat Gtf2h5 Gtf2h4 Cdk9 Gtf2h3 Ercc3 Ercc2 Polr2i Polr2f Polr2j Polr2e Nelfa Polr2h Nelfb Ell Polr2c Mnat1 Polr2d Supt4a Tcea1 Polr2b Tceb1 Tceb3 Supt16 Polr2k Polr2g Ccnt1 Ctdp1 Ssrp1 Ccnh Ccnk Cdk7 Polr2a Nelfe Supt5 Nelfcd Gtf2h1 Gtf2f1 Ncbp1 Ccnt2 Ncbp2 Gtf2h2 Gtf2f2 CASPASE ACTIVATION VIA EXTRINSIC APOPTOTIC SIGNALLING PATHWAY%REACTOME%R-HSA-5357769.2 Caspase activation via extrinsic apoptotic signalling pathway Fas Casp9 Casp8 Fadd Tradd Fasl Ripk1 Tnfrsf10b Tnfsf10 Casp3 Traf2 Ticam2 Dapk2 Ticam1 Unc5b Tlr4 Tlr3 Ly96 Dapk3 Dapk1 Cd14 Appl1 Unc5a Dcc Maged1 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER%REACTOME DATABASE ID RELEASE 59%76071 RNA Polymerase III Transcription Initiation From Type 3 Promoter Brf2 Pou2f1 Zfp143 Polr2f Polr2e Polr2h Tbp Bdp1 Polr2k Crcp Polr3a Snapc2 Polr3gl Snapc1 Polr3k Snapc4 Polr3h Polr3f Polr3g Snapc5 Polr1d Polr1c Polr3d Snapc3 Polr3e Polr3b Polr3c CONDENSATION OF PROPHASE CHROMOSOMES%REACTOME DATABASE ID RELEASE 59%2299718 Condensation of Prophase Chromosomes Hist1h2bg Hist1h2bh Hist1h2bp Hist1h2bm Plk1 Hist1h2bj Hist1h2bb Rb1 Hist2h3c1 Setd8 Cdk1 Mcph1 H2afz H2afx H2afj H2afb2 Hist2h2aa1 Smc4 Ncaph2 Smc2 Ncapg2 Hist1h3d Hist1h3h Ncapd3 Hist1h2ak Hist3h2ba Hist2h2be Hist1h2ag Hist2h2ac H3f3b H3f3a Hist1h2ah IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX%REACTOME%R-HSA-937042.2 IRAK2 mediated activation of TAK1 complex Map3k7 Irak2 Ubc Tab1 Tab2 Traf6 Tab3 HYDROXYCARBOXYLIC ACID-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 59%3296197 Hydroxycarboxylic acid-binding receptors Hcar1 Hcar2 MYOCLONIC EPILEPSY OF LAFORA%REACTOME%R-HSA-3785653.1 Myoclonic epilepsy of Lafora Ppp1r3c Ubc Gys2 Gys1 Gyg Epm2a EPIGENETIC REGULATION OF GENE EXPRESSION%REACTOME DATABASE ID RELEASE 59%212165 Epigenetic regulation of gene expression Suz12 Mbd2 Suv39h1 Phf1 Actb Tet3 Tet2 Tet1 Ercc6 Aebp2 Polr1a Polr1e Hdac1 H2afj H2afb2 Hdac2 Mnat1 Ubtf Sap30 Polr1b Suds3 Hist2h2be Sap30bp Ep300 Cbx3 Dnmt3a Hist2h2ac Mta1 Kat2b H3f3b Kat2a H3f3a Mta3 Hist1h2bg Hist1h2bh Gm10094 Dnmt3l Dnmt3b Cd3eap Hist1h2bp Hist1h2bm Ezh2 Hist1h2bj Rbbp7 Hist1h2bb Sin3b Ercc3 Baz2a Mtf2 Ercc2 Dnmt1 Gatad2a Gsk3b Gatad2b Hist1h3d Hist1h2ak Hist1h2ag Sin3a Jarid2 Hist1h2ah Phf19 Smarca5 Hist2h3c1 Sap30l Znrd1 Rbbp4 Baz1b Chd3 Chd4 Polr2f Polr2e Polr2h Sirt1 Tbp Mbd3 Polr2k Arid4b Rrp8 Hist3h2ba Uhrf1 Sap130 Polr1d Ttf1 Polr1c Gtf2h1 Ddx21 Gtf2h2 Gtf2h5 Gtf2h4 Eed Gtf2h3 Mta2 Sf3b1 H2afz Taf1d H2afx Taf1c Taf1b Taf1a Dek Hist2h2aa1 Ehmt2 Ccnh Cdk7 Mybbp1a SIGNALING BY MODERATE KINASE ACTIVITY BRAF MUTANTS%REACTOME%R-HSA-6802946.1 Signaling by moderate kinase activity BRAF mutants Map2k1 Fgg Mark3 Jak2 Itga2b Map2k2 Rap1a Nras Rap1b Araf Brap Hras Raf1 Arrb2 Arrb1 Cnksr1 Csk Cnksr2 Vcl Vwf Mapk3 Mapk1 Itgb3 Ksr1 Ywhab Phb Iqgap1 Map3k11 Kras Pebp1 Fn1 Tln1 Braf Apbb1ip Fga Fgb SIGNALING BY OVEREXPRESSED WILD-TYPE EGFR IN CANCER%REACTOME%R-HSA-5638302.1 Signaling by Overexpressed Wild-Type EGFR in Cancer Egf Egfr JOSEPHIN DOMAIN DUBS%REACTOME DATABASE ID RELEASE 59%5689877 Josephin domain DUBs Ubc Rad23a Park2 Josd2 Vcp Rad23b Atxn3 TOLL-LIKE RECEPTORS CASCADES%REACTOME%R-HSA-168898.3 Toll-Like Receptors Cascades Pik3c3 Tbk1 Pik3r4 Ppp2r1a Btrc Ikbke Mapk9 Nfkb2 Tank Nfkb1 Traf3 Ecsit Fbxw11 Saa3 Mapkapk3 Tnip2 Myd88 Nod2 Nod1 Dhx9 S100b Mapk10 Tlr5 Sigirr Map3k7 Hsp90b1 Peli1 Irak3 Irak2 Mapkapk2 Irak1 App Tab1 Map2k6 Tab2 Tab3 Mapk8 Jun Map3k1 Ripk2 Map2k7 Ager Map2k3 Map2k4 Map3k8 Rela Nfkbia Peli3 Nfkbib Irak4 Peli2 Apob Lgmn Casp8 Fadd Map2k1 Fgg Ripk1 S100a1 Cd180 Tlr2 S100a9 S100a8 Tlr6 Eea1 Ly86 Ptpn4 Itgb2 Socs1 Bpi Itgam Dnm2 Rps6ka5 Dnm1 Ppp2r1b Ticam2 Ube2d1 Ripk3 Birc3 Rps6ka3 Birc2 Rps6ka2 Ticam1 Rps6ka1 Traf6 Ikbkb Ube2v1 Tlr4 Ube2n Tlr3 Ly96 Cd14 Ikbkg Cd36 Dnm3 Tlr1 Tirap Ptpn11 Rbsn Irf7 Irf3 Cnpy3 Skp1a Ppp2r5d Tlr8 Unc93b1 Tlr7 Cul1 Vrk3 Elk1 Mef2c Mef2a Dusp3 Creb1 Mapk7 Plcg2 Lbp Dhx36 Atf2 Fga Fos Fgb Ppp2cb Chuk Tlr9 Ppp2ca Btk Ube2d3 Ubc Mapk3 Mapk1 Dusp7 Dusp6 Ctss Ctsb Ctsk Ctsl Mapk11 Mapk14 Dusp4 INTERACTIONS OF REV WITH HOST CELLULAR PROTEINS%REACTOME DATABASE ID RELEASE 59%177243 Interactions of Rev with host cellular proteins Nup85 Rcc1 Nup160 Nup37 Nup50 Tpr Nup43 Nup133 Xpo1 Ndc1 Nup214 Aaas Nup210 Nup188 Nup54 Nup35 Nupl2 Nup62 Ranbp1 Nup205 Nup155 Nup88 Pom121 Rae1 Nup93 Nup153 Npm1 Kpnb1 Ranbp2 Nup107 Ran DEFECTIVE CHST3 CAUSES SEDCJD%REACTOME DATABASE ID RELEASE 59%3595172 Defective CHST3 causes SEDCJD Bgn Dcn Bcan Ncan Vcan Cspg4 Cspg5 CARDIAC CONDUCTION%REACTOME DATABASE ID RELEASE 59%5576891 Cardiac conduction Abcc9 Cacng8 Cacng4 Cacng3 Akap9 Cacng2 Gata4 Nkx2-5 Scn1a Scn1b Kat2b Scn2a1 Scn5a Scn9a Scn2b Tbx5 Scn10a Hipk1 Hipk2 Scn3a Scn3b Scn11a Itpr1 Scn7a Scn8a Scn4b Itpr3 Scn4a Itpr2 Stim1 Trpc1 Orai1 Orai2 Prkaca Fxyd7 Kcnh2 Fxyd1 Fxyd4 Fxyd6 Cacng6 Kcnip4 Cacng1 Cacng5 Kcnq1 Kcnip1 Cacng7 Kcnip3 Camk2d Atp1a1 Camk2a Slc8a2 Slc8a1 Kcne1l Camk2b Fkbp1b Atp1b2 Atp1a2 Atp1a3 Slc8a3 Cacna1s Atp1b3 Atp1b1 Kcnd3 Camk2g Wwtr1 Dmpk Kcnd2 Cacna1f Kcnd1 Ryr3 Ryr1 Ryr2 Kcne4 Kcne3 Kcne2 Kcne1 Atp2a1 Trdn Atp2a3 Kcnk1 Atp2a2 Cacnb2 Kcnk12 Npr2 Cacnb3 Asph Cacna2d2 Npr1 Cacna1c Fgf14 Cacna1d Fgf13 Fgf11 Nppc Fgf12 Kcnj11 Kcnj2 Cacna2d1 Kcnk15 Cacna2d4 Nos1 Kcnj12 Cacna2d3 Nppa Atp2b3 Kcnk9 Kcnj4 Atp2b4 Atp2b1 Kcnk7 Corin Kcnk6 Atp2b2 Kcnk5 Ahcyl1 Kcnk2 Cacnb4 Cacnb1 Kcnk13 Kcnk3 Sri Tnni3 Kcnk10 Kcnk4 Kcnk18 Kcnk16 Kcnj14 NUCLEAR IMPORT OF REV PROTEIN%REACTOME DATABASE ID RELEASE 59%180746 Nuclear import of Rev protein Nup85 Rcc1 Nup160 Nup37 Nup50 Tpr Nup43 Nup133 Ndc1 Nup214 Aaas Nup210 Nup188 Nup54 Nup35 Nupl2 Nup62 Nup205 Nup155 Nup88 Pom121 Rae1 Nup93 Nup153 Npm1 Kpnb1 Ranbp2 Nup107 Ran INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS%REACTOME%R-HSA-141405.2 Inhibition of the proteolytic activity of APC C required for the onset of anaphase by mitotic spindle checkpoint components Cdc23 Ube2d1 Cdc27 Bub1b Cdc16 Cdc20 Ube2c Anapc16 Ube2e1 Anapc7 Anapc4 Anapc5 Anapc1 Anapc2 Bub3 Mad2l1 Anapc15 Anapc11 Anapc10 CELLULAR RESPONSE TO HEAT STRESS%REACTOME DATABASE ID RELEASE 59%3371556 Cellular response to heat stress Nup85 Nup160 Vcp Nup50 Tpr Ywhae Hsp90aa1 Mlst8 Ndc1 Nup214 Aaas Nup210 Nup188 Nup54 Mtor Nup35 Dnajb6 Nupl2 l7Rn6 Nup62 Hspa4 Nup205 Hspa9 Nup155 Nup88 Rps19bp1 Pom121 Rae1 Dnajb1 Bag5 Bag1 Hsf1 Mapkapk2 Rptor Dnajc7 Sirt1 Hsbp1 Dnajc2 Nup93 Hspa12a Hspa12b Bag2 Nup153 Bag3 Ccar2 Hspa14 Hspa4l St13 Hspa13 Crebbp Rpa2 Rpa1 Atm Nup107 Ep300 Hspa1a Rpa3 Hspa2 Hdac6 Fkbp4 Cryab Hspa1l Hspb8 Hspa8 Nup37 Nup43 Nup133 Camk2d Bag4 Hspa5 Camk2a Camk2b Akt1s1 Camk2g Mapk3 Mapk1 Gsk3b Hsph1 Ranbp2 Hsp90ab1 METABOLISM OF PROTEINS%REACTOME DATABASE ID RELEASE 59%392499 Metabolism of proteins Sec63 Klhdc3 Hdac7 Mbtps1 Mbtps2 Sec62 Yif1a Lmna Zbtb17 Cul7 Serp1 Csnk2a2 Hspa8 Ube2t Ino80 Parp1 Ino80c Ino80b Ino80e Ino80d Nfrkb Tnks Csnk2b Polb Tnks2 Actl6a Tfpt Actr8 Tcf7l2 Actr5 Slc34a1 Slc34a2 Hspa9 F2 Tgfbr1 Tgfbr2 B2m Ccne1 Mdm4 Ccne2 Igfbp3 Gas6 Bard1 Kat2b Kat2a Apc Axin1 Rraga Chm Ube2d1 Ccdc59 Cdc20 Ube2c Ube2e1 Park2 Josd2 Atxn3 Gngt1 Gng7 Gng4 Ccp110 Gcg Gngt2 Gng10 Rab8a Cetn2 Yy1 Tubb4a Tubb4b Rab11a Csnk1d Taf9b Tuba4a Dynll1 Gng11 Gng13 Gng12 Gnb2 Gnb1 Gnb3 Gnb5 Gnb4 Dync1i2 Gng8 Gip Gng3 Gng2 Dctn2 Dctn3 Esr1 Wipi1 Tuba1a Ern1 Acadvl Tnfaip3 Rab27b Extl3 Usp21 Eif2ak3 Tspyl2 Cd109 Hdgf Hspa5 Dync1h1 Gfpt1 Asna1 Add1 Srprb Ube2d3 Blm Pdia6 Ssr1 Otud7b Tpp1 Usp2 Pdia5 Mydgf Usp4 Cyld Wfs1 Dnajb9 Mdc1 Dnajb11 Tatdn2 Cxxc1 Fkbp14 Srd5a3 Ddx11 Srpr Dnajc3 Tfap2b Mmp1a Tgfb1 Tfap2c Ctsg Wrn Dag1 Gnao1 Adamts5 Ctsd Uchl5 Brca1 Nedd8 Usp15 Vdac1 Dph3 Dph2 Dph1 Dph7 Dph6 Dph5 Atxn7 Ar Rft1 Ckap4 Ubxn1 Coa4 Gata4 Foxo4 Tubal3 Vdac2 Vdac3 Proz Nagk Fbxo4 Smad1 Timm8a1 Fbxo6 Gcnt7 Atp5b Pomt1 Dcaf7 Pomgnt2 Pomt2 Zranb1 Pomgnt1 Apcs Dhps Usp12 Nsmce2 Hsp90b1 Usp11 Ddb2 Rab38 Cdc34 Sbspon Nsmce1 Cmas Cmc2 Rab32 Smad4 Napsa Usp19 Smad2 Rab31 Smad7 Usp13 Usp14 Aurka Mbd6 Usp16 Smad3 Pcmt1 Rab19 Rab17 Engase Rab12 Rab13 Rab10 2010111I01Rik Ep300 Rab20 Rab21 Rab29 L3mbtl2 Ube2i Rab23 Rab24 Apoa1 Rab25 Rab26 Sec61a2 Pml Calr Sec61g Sec61a1 Sec61b Pdia3 Gga2 Abca3 Eif5a Gga3 Ube2z Lmcd1 Ube2w Glb1 Gfpt2 Zdhhc2 Ube2k Gcnt1 Ube2h Foxk1 Gcnt3 Foxk2 Pcgf2 B3gnt3 B3gnt2 B3gnt7 B3gnt6 B3gnt5 B3gnt4 B3gnt9 B3gnt8 Fbxl5 Gnpnat1 Alg10b Fbxl3 Nudt14 F9 F7 Alg5 Gga1 F10 Pros1 Usp9x Rab36 Rab30 Rab33b Psmf1 Rab39 Proc Psme4 Skp2 Psme3 Rabggta Rabggtb Furin Hspd1 Slc30a5 Slc30a8 Cpe Ero1l Usp7 Myo5a Rab27a Slc30a6 Slc30a7 Kif5c Pcsk2 Shc1 Txn1 Exoc3 Exoc4 Myrip Tmem27 Ero1lb Exoc1 Exoc5 Psma7 Exoc6 Exoc8 Exoc7 Exoc2 Cpn1 Psmb5 Psmb4 Ubc Psmb7 Myc Psmb6 Psmb2 Cdkn2a Psmb3 Psmb1 Cct2 Cct6b Cct3 Trp53 Psme2 Sftpd Psme1 Nppa Psmb10 Smurf2 Psmb11 Csf2rb2 Csf2ra Cct5 Tcp1 Cct8 Cct4 Cct7 Usp8 Tram1 Rhoa Apeh Exosc9 Exosc8 Exosc7 Exosc5 Eef2 Exosc4 Nop56 Dcp2 Dis3 Exosc3 Exosc1 Exosc2 Nop58 Rpn2 Xrn2 Ripk1 Rab5a Gata6 Gata3 Traf2 Rpn1 Gspt1 Gspt2 Alppl2 Sftpb Sftpc Sftpa1 Derl1 Rce1 Prkdc Ube2r2 Hist1h2aa Otud7a Ube2q2 Adrm1 Hnrnpc Ucn Mettl21a Trmt112 St6gal2 Mme Actb Uap1 Chst4 B3galnt2 Hist1h2af Mat2b Asxl2 Asxl1 Tuba3b Mavs Magt1 Arl2 Otulin Fuk Rab22a B4galnt2 Msra Rnf2 Nsmce4a Igfals Tomm40 Hist3h2a Hcfc1 Hnrnpk Kin Hist2h2ab H2afb2 Gmppa Gmppb Adamts13 Adamts14 Rtf1 Adamts15 Timm21 Timm22 Arsg Cpb2 Thsd7a N6amt1 Arsi Arsb Arsa Dad1 Ide Hist2h2bb Usp5 Gfer Rpa1 Stambpl1 Arsk Arsj Hist2h2be Cpb1 Uchl3 Gba Timm9 Tomm70a Hist2h2ac Mboat4 Thsd7b H3f3b Tsta3 H3f3a Bcs1l Usp3 Hscb Hist1h2bg Gyltl1b Hist1h2bh Rnf135 Camkmt Paf1 Vcpkmt Vbp1 Asgr1 Large Fuom Hist1h2bp Asgr2 Hist1h2bm Rnf146 Adgrf5 Otud3 Hist1h2bj Ube2e3 Ctsh Hist1h2bb Kdm1b Tuba1b Tuba1c Tusc3 Wdr20 Rnf123 Mpi Tomm22 Ctsa Rnf128 Pofut2 Itm2b Pappa Wdr48 Gm21987 Stambp Srp54a Cox17 Eif5a2 Chchd5 Chchd7 Snca Phc3 Chchd2 Chchd3 Chchd4 Ptrh2 Ssr2 Fxn Tada3 Ssr3 Pdcl Ssr4 Yod1 Hist1h3d Eef1b2 Rnf181 Eef1g Phc2 Phc1 Eef1d Galnt12 Galnt13 Galnt10 Galnt11 Hist1h2ak Galnt16 Galnt18 Galnt14 Hist1h2ag Eef1a2 Galnt15 Trrap Rnf152 Otub2 Mvd Otub1 Otud5 Lonp2 Hist1h2ah Sema5b Etf1 Nup50 Pias4 Tpr Pias3 Ndc1 Nup214 Top2b Hist2h3c1 Aaas Nup210 Nup188 Nup54 Nup35 Srp72 Nupl2 Nup62 Nup205 Nup155 Ddost Nup88 Pom121 Top1 Rae1 Srp68 Nup93 Sumo3 Nup153 Mogs Cox19 Rnf144a Adora2b Adora2a Srp14 Adrb2 Fshb Ttf1 Srp19 Igf2 Igf1 Idh3g Hyou1 Rab3a Vamp2 Aco2 Stx1a Cs Nat8 Rab33a Tubb6 Wbscr17 Gzmf Becn1 Tubb3 Tubb1 Sorl1 Siah1a Rab5c Rab5b Dpagt1 Plg Timm17b Tuba8 Atp6ap2 Fbxw10 Usp42 Arrb2 Usp44 Traf3 Chchd10 Skiv2l Usp47 Arrb1 Samm50 Usp48 Usp49 Ngly1 Neu1 Siah2 Fn3k Neu3 Neu2 Neu4 Coa6 Iapp Rab3c Il33 Klf4 Usp37 Usp33 Usp28 Rab3d Usp30 Rab3b Nus1 Spon2 Slc17a5 Rab4b Galntl5 Suds3 Slc25a4 Fn3krp Spon1 Mmp2 Tomm6 Pappa2 Mpdu1 Tomm7 Rab37 Cyc1 Rab34 Rab35 Wdr61 Usp26 Usp20 Mta1 Rab42 Usp25 B3gntl1 Rab2b Ggcx Usp22 Ace2 Thsd4 Enpep Dhdds Coq2 Ltf Thsd1 Gmds Mettl20 Psmd12 Mysm1 Mettl22 Psmd11 Prl Keap1 Rab9 Sspo Fkbp9 Fkbp8 Psmd14 Mfge8 Smc5 Mul1 Psmd13 Smc6 Psmd10 Renbp Ptp4a2 Rab11b Pgm3 Pomc Timm10b B3glct Ctr9 Inha Rab43 Cfp Prmt3 Srp9 Igfbp6 Cdc73 Timm50 Rab39b Fpgt Chml P2ry2 Stt3a Pla2g7 Rgs7 Timm8b Rgs6 Rab8b Rgs9 Dmbt1 Ace Gsk3a N6amt2 Rab7 Odam Igfbp2 Shfm1 Timm44 Igfbp5 Igfbp4 A4gnt Cbx4 Eef2kmt Cbx8 Rab9b Mdm2 Cbx2 Pmm2 Galnt1 Pmm1 Galnt2 Pten Leo1 Rab18 Bmi1 Senp8 Galnt7 Galnt3 Rab6b Galnt6 Rab6a Grpel1 Grpel2 Senp5 Galnt4 Galnt5 Gsn Psmc6 Grp Fam175b Gapdhs St6galnac6 St6galnac5 Psmc5 St6galnac4 Crhr2 St6galnac3 Umod Psmc2 Canx Etfb Slc25a12 Ganab Pmpca Psmd2 Rab40c Pmpcb Rab40b Icmt Psmb9 Uba6 Psmb8 Tubb2b Tubb2a Pfdn2 Sphk1 Pfdn6 Pfdn1 Pfdn4 Pfdn5 Ldhd Mitf Alg11 Alg14 Psmc1 Slc25a13 Fbxw2 Psmc4 Kcna6 Psmc3 Fbxw5 Fbxw4 Fbxw9 Fbxw7 Dnajc19 Atp5a1 Senp1 Gnai2 Ring1 Gnai1 Calb1 Senp2 C1galt1c1 Dpp4 Anpep Gnai3 Tgfbi Cst3 Sncaip Bcl10 Mlec Gne Ppp2r5b Sp3 Dnajc24 Npl Tln1 Amdhd2 Ndnl2 Adamts3 Sec11c Nans Sec11a Arfgef2 Cdx2 Nanp Adamts6 Hist3h2ba Kif13a Fga Adamts7 Adamts2 Lep Alg3 Thbs1 Ffar4 Alg6 Gpr119 Alg8 Pcsk1 Prkcsh Alg9 Spcs1 Slc25a5 Alg1 Spcs2 Alg2 Spcs3 Mettl10 Pax6 Thbs2 Dolpp1 Adamts12 Isl1 Dolk Timm13 Adamts19 Axin2 Adamts10 Wac Mtx1 Mtx2 Klk13 Cpa3 Cftr Timm10 Bace1 Pomk Uchl1 Psma5 Tbcb Tbca Tbcc Msrb3 Psma4 Ifih1 Psma3 Adamts20 Psma6 C1galt1 B4gat1 Tbce H2afz St6galnac1 Psma2 Inhba H2afx Psma1 Inhbb Msrb2 Tbcd St6galnac2 Msrb1 Psmd9 Adamtsl3 Adamtsl4 Adamtsl1 Adamtsl2 Sumf2 Sumf1 Inhbc Hist2h2aa1 Inhbe Kif5a Kif5b Ap3m1 St8sia1 Ube2g2 Psmd1 Rhot1 Ube2g1 Snx3 Dohh Adamtsl5 Rnf20 Tnip1 Psmd3 St3gal1 Psmd4 St3gal2 Ogt Psmd6 St8sia5 Psmd5 Rnf40 St8sia4 Sae1 Psmd7 Ube2l3 Uba1 Uba2 Nlrp3 Psmd8 Ddx58 St3gal5 Tnip3 Hdac3 St3gal6 Ube2b Nup85 Ufd1l Nup160 Vcp Ube2a Rps27 Ube2l6 Trim25 Saa3 Tnip2 Nod2 Taz Nod1 Hif1a Map3k7 App Tab1 Ripk2 Aurkb Cdca8 Stag2 Nfkbia Usp10 Stag1 Ccl12 Nup107 Smc1a Rad21 Ffar1 Wrap53 Birc5 Nup37 Incenp Agt Nup43 Ruvbl1 Nup133 Stat3 Atp6v0d1 Smc3 Adamts4 Adamts1 Gnat1 Cma1 Gnat2 Gnat3 Adamts8 Adamts18 Ranbp2 Adamts16 Fam175a Xpnpep2 Spaca4 Lsamp Pcna Negr1 Mdga2 Gnaz Clspn Pigw Rnf168 Msln Ntm Rgs11 Brcc3 Trp53bp1 Ccna1 Cdc25a Uimc1 Ccna2 Babam1 Top2a Ly6k Sprn Nrn1 Izumo1r Psca Dpm1 Tex101 Dpm2 Dpm3 Gpld1 Prnd Opcml Lypd4 Lypd3 Lypd2 Cntn3 Pigv Mdga1 Pigx Otoa Pign Pigo Ly6g6d Cpm Ly6e Ly6d Ly6g6c Pigs Ly6h Pigu Plaur Pigt Pigc Tecta Prss41 Pigb Pigf Pigg Nrn1l Pigh Thy1 Reck Ntng1 Rtn4rl1 Rtn4rl2 Gp2 Piga Tectb Art4 Eif5 Art3 Adra2a Eif5b Lypd5 Eif2b5 Eif2b4 Adra2c Alpl Lypd8 Eif2b3 Lypd1 Eif2b2 Lypd6b Eif2b1 Pigk Pigm Pigl Prss21 Pgap1 Gpaa1 Mfi2 Cntn5 Rad52 Herc2 Usp18 Bre Bap1 Xrcc4 Tshb Ddit3 Nfyb Herpud1 Nfyc Chst8 Os9 Parn Rnf185 Atf6 Derl2 Rnf5 Igfbp1 Atf3 Rnf139 Atf4 Man1b1 Uggt2 Nfya Edem3 Asns Amfr Rab2a Trim13 Uggt1 Apoa4 Edem2 Edem1 Rnf103 Syvn1 Sel1l March6 Trappc2 Tgfa Trappc3 Ins2 Mgat5 Mcfd2 Trappc1 Rab1 Bst1 F5 Preb Copa F8 Sec24a Sec24b Sptan1 Sec13 Chst10 Tmed3 Mgat4a Mgat4b Sec24d Scfd1 Gria1 Sec24c Man2a1 Fut8 Stam Arcn1 Hgs Tfg St6gal1 Ykt6 Cd59b Stam2 Mgat4c Cog6 Lman2l Cog3 Cog4 Cog2 St8sia3 Sec31a Cog1 Ctage5 Gorasp1 Nsf St8sia2 Gpihbp1 Trappc6a St8sia6 Eif4b Trappc6b Ttr Tmed9 Man1c1 Bet1l Gbf1 Ankrd28 St3gal4 Man1a Trappc9 Mgat3 Napb Napg Mgat2 Mgat1 Napa Trappc5 Spta1 Trappc4 Sptbn4 Dctn5 Dctn6 Ctsz Folr2 Birc3 Dctn1 Birc2 Serpina1d Col7a1 Traf6 Sema5a Lman1l Dctn4 Areg Ube2n Serpina1a Dync1li2 Folr1 Dync1li1 Man1a2 Ikbkg Rab1b Ppp6r1 Ppp6r3 Eif4e Arf5 Cnih1 Kdelr2 Kdelr3 Eif4g1 Uso1 Bet1 Eif4ebp1 Stx17 Cnih3 Vnn3 Ctsc Cnih2 Cog7 Vnn1 Tmem115 Cog8 Fuca1 Arfgap3 Rpl39 Arfgap1 Rplp1 Eif2s1 Arfgap2 Sar1b Eif2s2 Eif3i Golgb1 Copb2 Eif3k Stx5a Eif3l Manea Eif3m Copb1 Rpl7 Ppp6c Rps21 Copz1 Rplp2 Eif3a Ank1 Eif3b Ank3 Eif3c Sec23a Copz2 Rps25 Rpl4 Cga Eif3d Lhb Trappc10 Rps26 Sec23ip Rps27l Copg1 Eif3e Rpl18a Gosr1 Golga2 Rpl34 Dynll2 Rpl32 Eif3f Gosr2 Arf1 Eif3h Kdelr1 Eif3g Arf3 Rpl26 Arf4 Rpl24 Dync1i1 Rps9 Eif2s3x Sptbn2 Trappc2l Rps7 Sptbn1 Rps5 Alpi Rab14 B4galt3 Tbc1d20 B4galt1 Pias1 Cope B4galt5 Rad23a B4galt4 B4galt6 Rad23b Xpc B4galt2 Ache Sec16b Sec22a Lman1 Sec22b Sptb Rpsa Muc1 Lman2 Rpl37 Muc4 Sec16a Rps4x Sec22c Muc15 Muc20 Muc13 Eif4a1 Eif4a2 Rpl22 Eif1ax Rpl10l Rab4a Rpl23 Bche Rpl39l Eif3j2 Rpl13a Rpl22l1 Slc35a1 Rps15a Rpl11 Rpl17 Rps3 Rpl19 Rpl18 Rps16 Rps14 Rps19 Rps18 Slc35c1 Eif4h Pabpc1 Rps11 Rps10 Hspg2 VLDL INTERACTIONS%REACTOME DATABASE ID RELEASE 59%8855121 VLDL interactions Fyn Reln Ap2m1 Lsr Clta Sh3kbp1 Ap2b1 Ap2a1 Ap2a2 Cltc Mylip Mttp Dab1 Apoc1 Nr1h2 Apoc4 P4hb Nr1h3 Pcsk9 Apobr Ap2s1 Apob Vldlr ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12%REACTOME%R-HSA-392170.2 ADP signalling through P2Y purinoceptor 12 Gnai2 Gngt1 Gnai1 Gng7 Gng4 Gnai3 Gngt2 P2ry12 Gng10 Gnat3 Gng11 Gng13 Gng12 Gnb2 Gnb1 Gnb3 Gnb5 Gnb4 Gng8 Gng3 Gng2 DAP12 INTERACTIONS%REACTOME%R-HSA-2172127.1 DAP12 interactions Akap9 Ppp2r1a Rac1 Csf2 Cd86 Jak1 H2-Q1 Cd80 Vav2 Adcy7 Adcy6 Adcy5 Adcy4 Adcy3 Adcy2 Prkar2a Adcy1 Frs2 Nras Frs3 Rasgrf1 Adcy9 Psmf1 Adcy8 Raf1 Psme4 Il5ra Fgf1 Bad Il17rd Fgf2 Cnksr1 Csk Cnksr2 Erbb2 Fgf9 Ptk2 Fgf7 Psme3 Fgf6 Fgf4 Fgf3 Trem1 Siglec15 Cd300e Klrd1 Klrk1 Clec5a Ppp5c Prkar1a Prkar1b Ranbp9 Cd300lb Ppp2cb Shc1 Lamtor2 Chuk Nrg2 Ppp2ca Shc3 Nrg1 Akt2 Akt3 Shc2 Psma7 Artn Nrtn Plcg1 Brap Psmb5 Psmb4 Ubc Nrg3 Psmb7 Nrg4 Psmb6 Psmb2 Psmb3 Psmb1 Mapk3 Akt1 Mapk1 Ksr1 Ptpra Dusp16 Dusp10 Map3k11 Pip4k2b Pip4k2a Trp53 Pip4k2c Paqr3 Pik3ap1 Pde1c Pde1b Psme2 Pde1a Psme1 Ncam1 Sos1 Rictor Braf Psmb10 Apbb1ip Ahcyl1 Psmb11 Csf2rb2 B2m Rapgef2 Grap2 Csf2ra Mov10 Lcp2 Casp9 Prkcd Prkce Actn2 Nf1 Prkcg Tsc2 Pdgfrb Pdgfra Mlst8 Kbtbd7 Prkca Vav1 Il2rg Arrb2 Egfr Gab1 Arrb1 Mtor Ret Phlpp1 Adrbk1 Vwf Phlpp2 Ins2 Sptan1 Pspn Map2k1 Rbx1 Fgg Cdkn1a Map2k2 Cul3 Psmd12 Pdgfb Psmd11 Rasgef1a Psmd14 Rasa3 Rasa4 Psmd13 Psmd10 Il2 Rasa2 Rasa1 Nefl Spred3 Kit Spred2 Grin2a Spta1 Spred1 Il5 Sptbn4 Ppp2r1b Ywhab Ago2 Ago1 Tnrc6c Kras Insr Trem2 Gsk3a Gsk3b Tnrc6b Gdnf Shfm1 Tnrc6a Ago4 Ago3 Itpr1 Trat1 Irs2 Mdm2 Lck Syngap1 Pten Hbegf Irs1 Il3ra Btc Il2ra Il2rb Itpr3 Ptpn11 Angpt1 Itpr2 Trib3 Psmc6 Egf Fgf23 Psmc5 Fgf22 Mark3 Psmc2 Fgf20 Psmd2 Dab2ip Prkacb Tek Psmb9 Psmb8 Araf Hras Grin1 Prkar2b Ppp2r5e Mapkap1 Dlg4 Ppp2r5c Rps6kb2 Ppp2r5d Ppp2r5a Psmc1 Psmc4 Psmc3 Pik3cb Foxo3 Sptbn2 Pik3cd Foxo1 Sptbn1 Itgb3 Fyn Creb1 Phb Grin2c Rasgrp4 Plcg2 Rasgrp3 Pebp1 Camk4 Ppp2r5b Syk Rasgrp1 Ier3 Tln1 Pik3ca Cdkn1b Fga Fgb Grin2d Prkaca Grin2b Nr4a1 Sptb Vav3 Prr5 Hgf Gfra2 Gfra3 Pip5k1a Gfra4 Ereg Jak2 Pea15a Itga2b Rap1a Jak3 Wdr83 Btk Camk2d Rap1b Camk2a Fgfr4 Camk2b Psma5 Rasal3 Tyrobp Rasal2 Sirpb1b Psma4 Psma3 Psma6 Akt1s1 Vcl Camk2g Psma2 Psma1 Gfra1 Pip5k1b Cd19 Pip5k1c Psmd9 Dusp7 Iqgap1 Fgf16 Dusp6 Dusp9 Fgf15 Dusp8 Klb Fgf18 Them4 Psmd1 Met Fn1 Rasal1 Dusp1 Psmd3 Psmd4 Pdpk1 Psmd6 Psmd5 Dusp2 Pik3r3 Psmd7 Pik3r1 Dusp5 Psmd8 Fgf10 Pik3r2 Dusp4 ANTAGONISM OF ACTIVIN BY FOLLISTATIN%REACTOME%R-HSA-2473224.2 Antagonism of Activin by Follistatin Fstl3 Inhba Fst Inhbb REVERSIBLE HYDRATION OF CARBON DIOXIDE%REACTOME%R-HSA-1475029.1 Reversible hydration of carbon dioxide Car13 Car5b Car14 Car5a Car9 Car4 Car2 Car3 Car7 Car1 Car12 Car6 PRE-NOTCH TRANSCRIPTION AND TRANSLATION%REACTOME DATABASE ID RELEASE 59%1912408 Pre-NOTCH Transcription and Translation Maml3 Notch1 E2f1 Tfdp2 Maml2 Tfdp1 Ccnd1 Maml1 Ago2 Notch4 Ago1 Tnrc6c Trp53 Jun Tnrc6b E2f3 Notch3 Tnrc6a Ago4 Notch2 Ago3 Crebbp Mamld1 Ep300 Kat2b Rbpj Kat2a Mov10 CAMK IV-MEDIATED PHOSPHORYLATION OF CREB%REACTOME DATABASE ID RELEASE 59%111932 CaMK IV-mediated phosphorylation of CREB Creb1 Camk4 DEFECTIVE POMT1 CAUSES MDDGA1, MDDGB1 AND MDDGC1%REACTOME%R-HSA-5083633.1 Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1 Dag1 PI5P REGULATES TP53 ACETYLATION%REACTOME DATABASE ID RELEASE 59%6811555 PI5P Regulates TP53 Acetylation Pip4k2b Map2k6 Tmem55b Pip4k2a Trp53 Pin1 Ep300 Pip4k2c Ing2 DISEASES OF IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 59%5260271 Diseases of Immune System Chuk Ticam1 Ikbkb Tlr4 Btk Tlr2 Tlr6 Tlr3 Ly96 Cd14 Ikbkg Rela Nfkb2 Nfkbia Cd36 Traf3 Nfkb1 Nfkbib Irak4 Tlr1 Tirap Myd88 Tlr5 ALPHA-LINOLENIC ACID (ALA) METABOLISM%REACTOME DATABASE ID RELEASE 59%2046106 alpha-linolenic acid (ALA) metabolism Abcd1 Fads1 Acaa1a Elovl1 Elovl5 Hsd17b4 Elovl3 Elovl2 Acot8 Fads2 Scp2 Acsl1 GLYCOGEN SYNTHESIS%REACTOME%R-HSA-3322077.1 Glycogen synthesis Pgm1 Ppp1r3c Ubc Nhlrc1 Gbe1 Gys2 Gys1 Gyg Ugp2 Epm2a Pgm2 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 59%381676 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Gngt1 Gng7 Akap5 Adcy6 Adcy5 Gng4 Gcg Gngt2 Prkar2a Glp1r Rap1a Gng10 Prkacb Adcy8 Rapgef4 Rapgef3 Prkar2b Kcnb1 Kcns3 Kcng2 Kcnc2 Iqgap1 Gng11 Gng13 Itpr1 Gng12 Gnb2 Gnb1 Gnb3 Prkar1a Gnb5 Prkar1b Gnb4 Prkaca Gng8 Itpr3 Gng3 Gng2 Itpr2 LYSOSOME VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 59%432720 Lysosome Vesicle Biogenesis Vamp8 Hspa8 M6pr Chmp2a Arrb1 Sh3gl2 Arf1 Dnm2 Ctsz App Ap4b1 Clvs1 Ap1g2 Clta Ap1s2 Ap1b1 Bloc1s1 Ap1s1 Cltc Dnajc6 Ap1g1 Ap1s3 Ap4e1 Vamp7 Hgs Ap4s1 Clvs2 Vamp2 Txndc5 Ap4m1 Ap1m2 Dnase2a Ap1m1 Gns Cltb ABC TRANSPORTER DISORDERS%REACTOME%R-HSA-5619084.4 ABC transporter disorders Psmc6 Psmc5 Psmc2 Vcp Os9 Psmd2 Rnf185 Derl2 Rnf5 Psmb9 Psmf1 Psmb8 Psme4 Sel1l Psmc1 Psmc4 Psmc3 Psme3 Psmd12 Psma7 Psmd11 Cftr Erlin2 Psmd14 Psma5 Psmb5 Psmb4 Ubc Psmd13 Psmd10 Psma4 Psmb7 Psma3 Psma6 Psmb6 Psmb2 Psmb3 Psmb1 Psma2 Psma1 Psmd9 Erlin1 Sftpb Sftpc Psmd1 Shfm1 Psme2 Sftpa1 Sftpd Psme1 Derl1 Derl3 Kcnj11 Abcc8 Psmd3 Psmd4 Psmb10 Psmd6 Psmd5 Psmd7 Psmb11 Psmd8 Erlec1 SIGNALING BY ERBB2%REACTOME%R-HSA-1227986.5 Signaling by ERBB2 Grb7 Memo1 Shc1 Egf Erbb2ip Prkcd Ptpn18 Prkce Nrg2 Ereg Nrg1 Akt2 Akt3 Nras Cdc37 Hsp90aa1 Matk Plcg1 Cul5 Prkca Hras Rnf41 Usp8 Yes1 Egfr Ubc Gab1 Nrg3 Nrg4 Rhoa Erbb2 Akt1 Ptk6 Fyn Diap1 Ptpn12 Kras Src Stub1 Pik3ca Sos1 Hbegf Btc Pik3r1 WNT MEDIATED ACTIVATION OF DVL%REACTOME DATABASE ID RELEASE 59%201688 WNT mediated activation of DVL Dvl1 Csnk2a2 Dvl3 Csnk1e Pip5k1b Csnk2b Dvl2 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION%REACTOME DATABASE ID RELEASE 59%3134963 DEx H-box helicases activate type I IFN and inflammatory cytokines production Irf7 Nfkb2 Nfkb1 App Saa3 Myd88 Ager Dhx36 Dhx9 S100b Rela THE ROLE OF GTSE1 IN G2 M PROGRESSION AFTER G2 CHECKPOINT%REACTOME DATABASE ID RELEASE 59%8852276 The role of GTSE1 in G2 M progression after G2 checkpoint Psmc6 Psmc5 Psmc2 Psmd2 Psmb9 Hsp90aa1 Psmb8 Psmf1 Psme4 Cdk1 Psmc1 Psmc4 Psmc3 Psme3 Ccnb2 Gtse1 Mapre1 Fkbpl Cdkn1a Psmd12 Plk1 Psma7 Psmd11 Psmd14 Psma5 Psmb5 Psmb4 Psmd13 Ubc Psmd10 Psma4 Psma3 Psmb7 Psma6 Psmb6 Psmb2 Psmb3 Psmb1 Psma2 Psma1 Psmd9 Trp53 Psmd1 Shfm1 Psme2 Psme1 Psmd3 Psmd4 Psmb10 Psmd6 Psmd5 Hsp90ab1 Psmd7 Psmb11 Psmd8 THE ROLE OF NEF IN HIV-1 REPLICATION AND DISEASE PATHOGENESIS%REACTOME%R-HSA-164952.1 The role of Nef in HIV-1 replication and disease pathogenesis Ap2m1 Cd8b1 Ap2a1 Ap2a2 Arf1 Elmo1 Ap2s1 Fyn Hck Rac1 Dock2 Pak2 Ap2b1 Atp6v1h Ap1s2 Ap1b1 Ap1s1 Ap1g1 Pacs1 Lck H2-Q10 Cd4 Ap1s3 B2m Ap1m2 Ap1m1 BIOTIN TRANSPORT AND METABOLISM%REACTOME%R-HSA-196780.1 Biotin transport and metabolism Mccc2 Pdzd11 Acacb Mccc1 Hlcs Btd Pcca Slc5a6 Pcx Acaca Pccb RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER%REACTOME%R-HSA-76066.2 RNA Polymerase III Transcription Initiation From Type 2 Promoter Polr2f Polr2e Polr2h Tbp Gtf3c1 Gtf3c6 Gtf3c3 Gtf3c2 Bdp1 Gtf3c4 Polr2k Crcp Polr3a Polr3gl Polr3k Polr3h Brf1 Polr3f Polr3g Gtf3c5 Polr1d Polr1c Polr3d Polr3e Polr3b Polr3c RESPONSE TO METAL IONS%REACTOME DATABASE ID RELEASE 59%5660526 Response to metal ions Mt2 Mt4 Mt1 Mt3 SULFUR AMINO ACID METABOLISM%REACTOME DATABASE ID RELEASE 59%1614635 Sulfur amino acid metabolism Gclm Slc25a10 Ahcy Cndp2 Gclc Tst Ado Cdo1 Cth Mri1 Adi1 Cbs Got1 Ethe1 Enoph1 Bhmt2 Suox Apip Sqrdl Mtap Csad Mtrr Bhmt Mat1a Mtr TIGHT JUNCTION INTERACTIONS%REACTOME DATABASE ID RELEASE 59%420029 Tight junction interactions Cldn6 Cldn9 Cldn3 Cldn4 Cldn5 Cldn2 Cldn1 Cldn23 Cldn22 Cldn20 Inadl Cldn19 Cldn17 Cldn18 Cldn16 Cldn10 F11r Cldn15 Pard3 Cldn11 Crb3 Cldn14 Cldn12 Prkci Pard6b Mpp5 Pard6a Cldn8 Pard6g Cldn7 PRE-NOTCH PROCESSING IN THE ENDOPLASMIC RETICULUM%REACTOME DATABASE ID RELEASE 59%1912399 Pre-NOTCH Processing in the Endoplasmic Reticulum Notch4 Notch1 Poglut1 Pofut1 Notch3 Notch2 SPERM:OOCYTE MEMBRANE BINDING%REACTOME DATABASE ID RELEASE 59%1300652 Sperm:Oocyte Membrane Binding Izumo4 Izumo2 Izumo1 Cd9 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE%REACTOME%R-HSA-392154.1 Nitric oxide stimulates guanylate cyclase Pde3a Gucy1b3 Pde9a Pde3b Gucy1a2 Gucy1a3 Pde2a Pde5a Prkg2 Nos3 Pde1b Pde1a Itpr1 Nos1 Pde10a Nos2 Kcnmb2 Pde11a Kcnma1 Kcnmb4 Mrvi1 Kcnmb1 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS%REACTOME DATABASE ID RELEASE 59%111465 Apoptotic cleavage of cellular proteins Casp8 Prkcd Apc Cdh1 Bmx Lmnb1 Clspn Bcap31 Casp3 Add1 Tjp1 Casp7 Tjp2 Prkcq Dsg1a Acin1 Ptk2 Stk26 Stk24 Dsg3 Dsp Dsg2 Plec Birc2 Fnta Satb1 Pkp1 Sptan1 Dbnl Casp6 Gas2 Rock1 Vim Gsn GAMMA-CARBOXYLATION OF PROTEIN PRECURSORS%REACTOME%R-HSA-159740.3 Gamma-carboxylation of protein precursors Proz F10 Pros1 Gas6 F9 F2 F7 Ggcx Proc SYNTHESIS OF PIPS AT THE ER MEMBRANE%REACTOME DATABASE ID RELEASE 59%1483248 Synthesis of PIPs at the ER membrane Pi4k2b Sacm1l Pi4ka S45 MUTANTS OF BETA-CATENIN AREN'T PHOSPHORYLATED%REACTOME%R-HSA-5358751.1 S45 mutants of beta-catenin aren't phosphorylated Ppp2cb Ppp2r1b Apc Axin1 Ppp2ca Amer1 Csnk1a1 Ctnnb1 Gsk3b Ppp2r1a Ppp2r5b Ppp2r5e Ppp2r5c Ppp2r5d Ppp2r5a GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION%REACTOME%R-HSA-163841.2 Gamma carboxylation, hypusine formation and arylsulfatase activation Dph3 Dph2 F10 Dph1 Pros1 Dph7 Dph6 Dph5 Icmt Proc Proz Fn3k Dhps Eif5a2 Eif5a Sumf2 Sumf1 Eef2 Gas6 Arsg Arsi Dnajc24 Arsb Dohh Arsa Fn3krp Furin Arsk Arsj F2 F9 Ggcx F7 DEFECTIVE PRO-SFTPC CAUSES PULMONARY SURFACTANT METABOLISM DYSFUNCTION 2 (SMDP2) AND RESPIRATORY DISTRESS SYNDROME (RDS)%REACTOME DATABASE ID RELEASE 59%5688354 Defective pro-SFTPC causes pulmonary surfactant metabolism dysfunction 2 (SMDP2) and respiratory distress syndrome (RDS) Sftpb Sftpc FGFR1 MUTANT RECEPTOR ACTIVATION%REACTOME DATABASE ID RELEASE 59%1839124 FGFR1 mutant receptor activation Fgf23 Bcr Fgf20 Fgfr1 Myo18a Stat5b Trim24 Stat5a Bag4 Cux1 Erlin2 Fgfr1op2 Stat3 Gab2 Fgf1 Cpsf6 Zmym2 Fgf2 Fgf9 Fgf6 Fgf4 Stat1 Pik3ca Pik3r1 Fgfr1op HORMONE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 59%375281 Hormone ligand-binding receptors Lhb Gpha2 Tshr Gnrh1 Fshr Lhcgr Fshb Tshb Cga Gnrhr SYNTHESIS OF PS%REACTOME DATABASE ID RELEASE 59%1483101 Synthesis of PS Ptdss2 Ptdss1 MET ACTIVATES STAT3%REACTOME%R-HSA-8875791.1 MET activates STAT3 Stat3 Met Hgf RMTS METHYLATE HISTONE ARGININES%REACTOME%R-HSA-3214858.2 RMTs methylate histone arginines Prmt7 Hist1h2aa Prmt6 Pbrm1 Jak2 Arid2 Smarcc2 Smarcc1 Actl6b Smarca4 Hist1h2af Smarca2 Arid1b Rbbp7 Arid1a Hist2h3c1 Prmt5 H2afz H2afx Prmt1 Wdr77 Cdk4 Prmt3 Hist3h2a H2afj Ccnd1 H2afb2 Hist2h2ab Hist2h2aa1 Carm1 Hist1h3d Smarcb1 Smarcd2 Hist1h2ak Smarcd1 Wdr5 Coprs Hist1h2ag Smarce1 Actl6a Smarcd3 Dnmt3a Hist2h2ac Hist1h2ah VITAMIN C (ASCORBATE) METABOLISM%REACTOME DATABASE ID RELEASE 59%196836 Vitamin C (ascorbate) metabolism Slc23a2 Gsto1 Cyb5r3 Gsto2 Slc2a3 Slc23a1 Slc2a1 Cyb5a INTERACTION WITH CUMULUS CELLS%REACTOME%R-HSA-2534343.1 Interaction With Cumulus Cells Hyal5 CONSTITUTIVE SIGNALING BY EGFRVIII%REACTOME DATABASE ID RELEASE 59%5637810 Constitutive Signaling by EGFRvIII Shc1 Egf Kras Nras Hsp90aa1 Cdc37 Plcg1 Pik3ca Hras Sos1 Egfr Gab1 Cbl Pik3r1 ACYL CHAIN REMODELLING OF PE%REACTOME DATABASE ID RELEASE 59%1482839 Acyl chain remodelling of PE Pla2g5 Pla2g4d Pla2g4e Pla2g4f Mboat2 Pla2g2e Pla2g12a Pla2g2d Pla2g1b Pla2g2f Pnpla8 Lpcat4 Lpcat3 Pla2g6 Pla2g4a Pla2g10 Abhd4 Pla2r1 Pla2g16 Mboat1 Plbd1 Pla2g4c Hrasls5 Hrasls Pla2g3 BUDDING%REACTOME DATABASE ID RELEASE 59%168302 Budding CREB PHOSPHORYLATION%REACTOME DATABASE ID RELEASE 59%199920 CREB phosphorylation Creb1 Mapkapk2 Rps6ka3 Rps6ka2 Rps6ka1 Rps6ka5 PROTON-COUPLED NEUTRAL AMINO ACID TRANSPORTERS%REACTOME DATABASE ID RELEASE 59%428559 Proton-coupled neutral amino acid transporters Slc36a1 Slc36a2 DEFECTIVE CSF2RA CAUSES PULMONARY SURFACTANT METABOLISM DYSFUNCTION 4 (SMDP4)%REACTOME%R-HSA-5688890.1 Defective CSF2RA causes pulmonary surfactant metabolism dysfunction 4 (SMDP4) Sftpb Sftpc Csf2rb2 Sftpa1 Sftpd Csf2ra ACTIVATION OF NIMA KINASES NEK9, NEK6, NEK7%REACTOME%R-HSA-2980767.2 Activation of NIMA Kinases NEK9, NEK6, NEK7 Ccnb2 Cdk1 Plk1 Nek6 Nek7 Nek9 SURFACTANT METABOLISM%REACTOME%R-HSA-5683826.1 Surfactant metabolism Abca3 P2ry2 Ccdc59 Lmcd1 Dmbt1 Slc34a1 Napsa Ckap4 Zdhhc2 Sftpb Adgrf5 Sftpc Sftpa1 Sftpd Ctsh Adora2b Adra2a Adora2a Adra2c Gata6 Slc34a2 Ttf1 Csf2rb2 Csf2ra PEPTIDE CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 59%156902 Peptide chain elongation Rpl39 Rplp1 Rpl7 Rps21 Rps27 Rplp2 Rps25 Rpl4 Rps26 Rps27l Rpl18a Rpl34 Rpl32 Rpl26 Rpl24 Rps9 Rps7 Rps5 Rpl22 Rpl10l Rpl23 Eef2 Rpl39l Rpl13a Rpl22l1 Rps15a Rpl11 Rpl17 Rps3 Rpl19 Rpl18 Rps16 Rps14 Rps19 Rps18 Rps11 Rps10 Rpsa Rpl37 Rps4x INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME DATABASE ID RELEASE 59%109606 Intrinsic Pathway for Apoptosis Casp9 Casp8 Trp53bp2 Ppp3cc Ywhaz Ywhah Sfn Akt2 Akt3 Ppp1r13b Ywhag Ywhae Xiap Casp3 Diablo Casp7 Bax Bad Dynll2 E2f1 Trp73 Nmt1 Tfdp2 Akt1 Bid Tfdp1 Ywhab Bcl2 Bcl2l1 Trp53 Bak1 Gzmb Trp63 Mapk8 Bmf Dynll1 Ppp3r1 Bcl2l11 Apaf1 SIGNALING BY FGFR2 IN DISEASE%REACTOME%R-HSA-5655253.1 Signaling by FGFR2 in disease Fgf23 Fgf22 Fgf20 Frs2 Nras Plcg1 Hras Fgf1 Gab1 Fgf2 Fgf9 Fgf7 Fgf6 Fgf4 Fgf3 Polr2i Polr2f Polr2j Polr2e Polr2h Fgf16 Polr2c Polr2d Kras Polr2b Fgf18 Polr2k Polr2g Pik3ca Sos1 Polr2a Pik3r1 Gtf2f1 Ncbp1 Fgf10 Ncbp2 Fgfr2 Gtf2f2 GLUTATHIONE CONJUGATION%REACTOME DATABASE ID RELEASE 59%156590 Glutathione conjugation Oplah Gstm5 Gstz1 Gclm Gstm7 Mgst1 Ggt1 Gsta3 Mgst2 Mgst3 Gstt2 Cndp2 Gstt1 Gclc Gss Gstm2 Gstk1 Ggt6 Ggt7 Gstm4 Hpgds Gstm1 Ggt5 Chac2 Chac1 Gsto1 Gm10639 Gsto2 Akr1a1 Esd TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION%REACTOME DATABASE ID RELEASE 59%975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7 8 or 9 activation Ppp2r1a Btrc Mapk9 Nfkb2 Nfkb1 Ecsit Fbxw11 Skp1a Saa3 Ppp2r5d Tlr8 Mapkapk3 Tlr7 Tnip2 Myd88 Nod2 Cul1 Nod1 Dhx9 Vrk3 S100b Elk1 Mef2c Mapk10 Mef2a Map3k7 Dusp3 Mapk7 Peli1 Creb1 Mapkapk2 Irak2 Irak1 App Map2k6 Tab1 Tab2 Jun Mapk8 Tab3 Map3k1 Ripk2 Map2k7 Ager Map2k3 Map2k4 Map3k8 Atf2 Rela Nfkbia Peli3 Nfkbib Irak4 Fos Peli2 Ppp2cb Map2k1 Chuk Tlr9 Ppp2ca Ubc Mapk3 Rps6ka5 Mapk1 Ppp2r1b Ticam2 Dusp7 Rps6ka3 Dusp6 Rps6ka2 Ticam1 Rps6ka1 Traf6 Ikbkb Ube2v1 Tlr4 Ube2n Tlr3 Ly96 Cd14 Ikbkg Mapk11 Mapk14 Dusp4 GLI3 IS PROCESSED TO GLI3R BY THE PROTEASOME%REACTOME%R-HSA-5610785.1 GLI3 is processed to GLI3R by the proteasome Psmc6 Psmc5 Psmc2 Psmd2 Prkacb Psmb9 Psmb8 Psmf1 Psme4 Btrc Skp1a Psmc1 Psmc4 Psmc3 Cul1 Psme3 Prkaca Rbx1 Csnk1a1 Psmd12 Psma7 Psmd11 Psmd14 Psma5 Psmb5 Psmb4 Psmd13 Ubc Psmd10 Psma4 Psma3 Psmb7 Psma6 Psmb6 Psmb2 Psmb3 Psma2 Psmb1 Psma1 Sufu Psmd9 Gli3 Gsk3b Psmd1 Shfm1 Psme2 Psme1 Psmd3 Psmd4 Psmb10 Psmd6 Psmd5 Psmd7 Psmb11 Psmd8 S37 MUTANTS OF BETA-CATENIN AREN'T PHOSPHORYLATED%REACTOME DATABASE ID RELEASE 59%5358749 S37 mutants of beta-catenin aren't phosphorylated Ppp2cb Ppp2r1b Apc Axin1 Ppp2ca Amer1 Csnk1a1 Ctnnb1 Gsk3b Ppp2r1a Ppp2r5b Ppp2r5e Ppp2r5c Ppp2r5d Ppp2r5a P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 59%69580 p53-Dependent G1 S DNA damage checkpoint Psmc6 Psmc5 Psmc2 Psmd2 Psmb9 Psmb8 Psmf1 Psme4 Ccne1 Mdm4 Cdk2 Ccne2 Psmc1 Ccna1 Psmc4 Psmc3 Ccna2 Psme3 Chek2 Atm Cdkn1b Cdkn1a Psmd12 Psma7 Psmd11 Psmd14 Psma5 Psmb5 Psmb4 Psmd13 Ubc Psmd10 Psma4 Psmb7 Psma3 Pcbp4 Psma6 Psmb6 Psmb2 Psmb3 Psmb1 Psma2 Psma1 Zfp385a Psmd9 Trp53 Psmd1 Shfm1 Psme2 Psme1 Rfwd2 Psmd3 Psmd4 Mdm2 Psmb10 Psmd6 Psmd5 Psmd7 Psmb11 Psmd8 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC)%REACTOME DATABASE ID RELEASE 59%975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Rpl39 Rplp1 Etf1 Rpl7 Rps21 Ppp2r1a Rps27 Rplp2 Rps25 Rpl4 Rps26 Rps27l Rpl18a Rpl34 Rpl32 Upf3a Upf1 Rpl26 Rpl24 Rps9 Rps7 Upf2 Rps5 Dcp1a Magoh Ppp2r2a Smg8 Smg1 Rpsa Smg6 Rpl37 Ncbp1 Smg7 Rps4x Smg9 Ncbp2 Smg5 Rbm8a Ppp2ca Casc3 Eif4a3 Upf3b Rnps1 Magohb Rpl22 Gspt1 Rpl10l Rpl23 Rpl39l Gspt2 Rpl13a Rpl22l1 Rps15a Rpl11 Rpl17 Rps3 Rpl19 Rpl18 Rps16 Rps14 Rps19 Rps18 Pabpc1 Rps11 Eif4g1 Rps10 NONHOMOLOGOUS END-JOINING (NHEJ)%REACTOME%R-HSA-5693571.1 Nonhomologous End-Joining (NHEJ) Hist1h2bg Paxip1 Prkdc Hist1h2bh Lig4 Xrcc5 Tdp2 Tdp1 Xrcc6 Fam175a Hist1h2bp Hist1h2bm Pias4 Hist1h2bj Poll Rnf168 Hist1h2bb Ube2v2 Dclre1c Brcc3 Trp53bp1 Rad50 Mdc1 H2afx Uimc1 Babam1 Herc2 Nbn Bre Kat5 Bard1 Ube2n Whsc1 Hist1h3h Brca1 Mre11a Atm Hist2h2be Hist3h2ba Xrcc4 Rif1 Polm DIGESTION OF DIETARY CARBOHYDRATE%REACTOME DATABASE ID RELEASE 59%189085 Digestion of dietary carbohydrate Amy1 Mgam Lct Sis Amy2a3 Treh GABA SYNTHESIS%REACTOME%R-HSA-888568.1 GABA synthesis Gad2 Gad1 TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN CYTOCHROME C RELEASE%REACTOME DATABASE ID RELEASE 59%6803204 TP53 Regulates Transcription of Genes Involved in Cytochrome C Release Prelid1 Triap1 Trp53bp2 Trp53 Trp63 Trp53inp1 Ppp1r13b Slmo1 Crebbp Steap3 Aifm2 Bax Atm Trp73 Bnip3l Bid CA ACTIVATED K+ CHANNELS%REACTOME DATABASE ID RELEASE 59%1296052 Ca activated K+ channels Kcnn2 Kcnn3 Kcnn1 Kcnn4 Kcnmb2 Kcnma1 Kcnmb4 Kcnmb1 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL%REACTOME%R-HSA-112314.3 Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Akap5 Grip1 Cacng8 Actn2 Gria2 Grip2 Cacng4 Prkcg Cacng3 Akap9 Cacng2 Myo6 Tspan7 Pick1 Gria3 Gria4 Prkcb Prkca Gria1 Dlg1 Nsf Ap2a1 Dlg3 Nefl Grin2a Rps6ka6 Rps6ka3 Rps6ka2 Rps6ka1 Rras Gnat3 Arhgef9 Mdm2 Grik3 Adcy7 Gngt1 Gng7 Adcy6 Adcy5 Gng4 Adcy4 Adcy3 Adcy2 Gngt2 Adcy1 Prkacb Gng10 Rasgrf1 Adcy9 Adcy8 Raf1 Hras Grin1 Dlg4 Chrnb2 Gnai2 Gnai1 Creb1 Kcnj5 Grin2c Kcnj9 Gnai3 Chrnb4 Chrnb3 Grik2 Camk4 Gnal Gabbr2 Gabbr1 Gng11 Gng13 Gng12 Gnb2 Gnb1 Gnb3 Gnb5 Gnb4 Grik1 Grin2d Prkaca Gng8 Grin2b Gng3 Gng2 Gabrr2 Gabrr3 Gabrb2 Gabrr1 Camkk1 Kcnj10 Gabrq Kcnj3 Chrnd Gabra2 Kcnj16 Camk2d Kcnj15 Plcb1 Chrng Plcb2 Camk2a Gabra5 Gabra1 Camk2b Gabra6 Chrna9 Gabra3 Chrne Gabra4 Chrna4 Grik5 Chrna5 Grik4 Chrna3 Chrna1 Camk2g Chrna6 Chrna7 Kcnj6 Gabrg2 Gabrg3 Mapk1 Chrna2 Kcnj2 Braf Kcnj12 Pdpk1 Plcb3 Kcnj4 Ncald Gabrb3 Gabrb1 RHESUS GLYCOPROTEINS MEDIATE AMMONIUM TRANSPORT.%REACTOME DATABASE ID RELEASE 59%444411 Rhesus glycoproteins mediate ammonium transport. Rhcg Rhbg Rhag DEFECTIVE CYP11A1 CAUSES ADRENAL INSUFFICIENCY, CONGENITAL, WITH 46,XY SEX REVERSAL (AICSR)%REACTOME DATABASE ID RELEASE 59%5579026 Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR) Fdx1 Fdx1l Cyp11a1 Fdxr GLYCEROPHOSPHOLIPID CATABOLISM%REACTOME%R-HSA-6814848.1 Glycerophospholipid catabolism Gdpd1 Gde1 Gdpd5 Enpp6 Pnpla6 Gdpd3 Pnpla7 ACTIVATION OF BID AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%R-HSA-75108.2 Activation of BID and translocation to mitochondria Casp8 Gzmb Nmt1 Bid DECTIN-2 FAMILY%REACTOME DATABASE ID RELEASE 59%5621480 Dectin-2 family Fyn Clec10a Muc15 Clec4a2 Fcer1g Clec4n Muc20 Plcg2 Clec4b2 Syk Muc13 Lyn Clec4d Muc1 Muc4 Clec4e DISEASES ASSOCIATED WITH GLYCOSAMINOGLYCAN METABOLISM%REACTOME%R-HSA-3560782.2 Diseases associated with glycosaminoglycan metabolism Agrn Bgn Dcn Bcan Lum Cspg4 Cspg5 Ncan Vcan Sdc3 Sdc4 Gpc6 Sdc2 Gpc3 Sdc1 Gpc5 Gpc2 Gpc4 Fmod Omd Prelp Kera Ogn Hspg2 Gpc1 TOXICITY OF BOTULINUM TOXIN TYPE A (BONT A)%REACTOME%R-HSA-5250968.1 Toxicity of botulinum toxin type A (BoNT A) Sv2c Sv2b Sv2a Snap25 REGULATION OF GENE EXPRESSION IN EARLY PANCREATIC PRECURSOR CELLS%REACTOME%R-HSA-210747.1 Regulation of gene expression in early pancreatic precursor cells Hnf1b Nkx6-1 Onecut3 Onecut1 Ptf1a Pdx1 Fgf10 COMPLEMENT CASCADE%REACTOME DATABASE ID RELEASE 59%166658 Complement cascade C2 C8b Cfb C8a C8g Pros1 Cfd Crp C3 Cd46 C1rb Colec10 Mbl2 Gzmm C5ar2 Clu C6 Cfi C9 C7 Cfh Colec11 Hc C3ar1 Vtn C1s2 C1qc C1qb C5ar1 C1qa Fcnb Cd59b BINDING OF TCF LEF:CTNNB1 TO TARGET GENE PROMOTERS%REACTOME DATABASE ID RELEASE 59%4411364 Binding of TCF LEF:CTNNB1 to target gene promoters Tcf7l1 Axin2 Myc Lef1 Tcf7 Ctnnb1 Tcf7l2 CD22 MEDIATED BCR REGULATION%REACTOME%R-HSA-5690714.2 CD22 mediated BCR regulation Cd79b Cd22 Lyn Cd79a Ptpn6 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS%REACTOME DATABASE ID RELEASE 59%2691232 Constitutive Signaling by NOTCH1 HD Domain Mutants Mib2 Adam10 Neurl1a Neurl1b Ubc Notch1 Adam17 Jag2 Dll1 Mib1 Dll4 Jag1 STIMULATION OF THE CELL DEATH RESPONSE BY PAK-2P34%REACTOME DATABASE ID RELEASE 59%211736 Stimulation of the cell death response by PAK-2p34 Casp3 Pak2 REGULATION OF TP53 ACTIVITY THROUGH ACETYLATION%REACTOME%R-HSA-6804758.2 Regulation of TP53 Activity through Acetylation Kat6a Pml Akt2 Akt3 Brd7 Brpf3 Rbbp7 Mta2 Brpf1 Ing5 Hdac1 Pin1 Ing2 Rbbp4 Chd3 Chd4 Akt1 Hdac2 Pip4k2b Map2k6 Pip4k2a Trp53 Pip4k2c Gatad2a Gatad2b Mbd3 Tmem55b Ep300 Meaf6 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 59%372708 p130Cas linkage to MAPK signaling for integrins Fgg Itga2b Rap1a Rap1b Fn1 Tln1 Bcar1 Apbb1ip Fga Fgb Crk Vwf Ptk2 Itgb3 G-PROTEIN ACTIVATION%REACTOME%R-HSA-202040.1 G-protein activation Gngt1 Gng7 Gng4 Gngt2 Gng10 Gnaz Pomc Pdyn Gnai2 Gnai1 Gnai3 Gnat1 Gnat2 Gnat3 Gnao1 Gng11 Gng13 Gng12 Gnb2 Gnb1 Gnb3 Gnb5 Gnb4 Gng8 Gng3 Gng2 Oprm1 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR%REACTOME DATABASE ID RELEASE 59%442982 Ras activation uopn Ca2+ infux through NMDA receptor Actn2 Grin2c Akap9 Rasgrf1 Camk2d Camk2a Hras Camk2b Grin1 Dlg4 Nefl Grin2d Camk2g Grin2b Grin2a PROTEIN FOLDING%REACTOME%R-HSA-391251.1 Protein folding Cct5 Gngt1 Gapdhs Gng7 Tcp1 Tubb6 Cct8 Gng4 Cct4 Cct7 Tubb3 Gngt2 Tubb1 Actb Gng10 Gnaz Tubb2b Tubal3 Tubb2a Tuba8 Pfdn2 Rgs11 Fbxw10 Pfdn6 Tuba3b Sphk1 Pfdn1 Ccne1 Pfdn4 Fbxo4 Pfdn5 Arl2 Skiv2l Fbxo6 Ccne2 Fbxw2 Dcaf7 Fbxw5 Fbxw4 Fbxw9 Fbxw7 Gnai2 Tubb4a Gnai1 Tubb4b Usp11 Gnai3 Tuba4a Gng11 Nop56 Gng13 Gng12 Gnb2 Arfgef2 Gnb1 Gnb3 Kif13a Gnb5 Gnb4 Gba Gng8 Gng3 Gng2 Wrap53 Xrn2 Csnk2a2 Vbp1 Tuba1a Fkbp9 Tbcb Tuba1b Stat3 Tbca Tuba1c Tbcc Tbce Tbcd Cct2 Cct6b Cct3 Rgs7 Rgs6 Rgs9 Trp53 Ap3m1 Gnat1 Gnat2 Pdcl Gnat3 Gnao1 Csnk2b Fbxl5 Fbxl3 Lonp2 Hdac3 RAP1 SIGNALLING%REACTOME%R-HSA-392517.2 Rap1 signalling Ywhab Ywhaz Rap1gap2 Rap1a Rap1gap Prkacb Rasgrp1 Rap1b Raf1 Sipa1 Rapgef4 Rapgef3 Rasgrp2 Prkaca MYD88-INDEPENDENT TLR3 TLR4 CASCADE%REACTOME DATABASE ID RELEASE 59%166166 MyD88-independent TLR3 TLR4 cascade Irf7 Tbk1 Ppp2r1a Irf3 Btrc Mapk9 Ikbke Nfkb2 Tank Nfkb1 Traf3 Fbxw11 Skp1a Saa3 Ppp2r5d Mapkapk3 Tnip2 Myd88 Nod2 Cul1 Nod1 Dhx9 Vrk3 S100b Elk1 Mef2c Mapk10 Mef2a Dusp3 Map3k7 Mapk7 Creb1 Mapkapk2 Irak2 Irak1 App Map2k6 Tab1 Tab2 Jun Mapk8 Tab3 Ripk2 Map2k7 Ager Map2k3 Map2k4 Map3k8 Rela Atf2 Nfkbia Nfkbib Fos Ppp2cb Casp8 Map2k1 Fadd Chuk Ppp2ca Ripk1 Ube2d3 Ubc Mapk3 Rps6ka5 Mapk1 Ppp2r1b Ticam2 Dusp7 Ube2d1 Ripk3 Birc3 Rps6ka3 Birc2 Dusp6 Rps6ka2 Ticam1 Rps6ka1 Traf6 Ikbkb Ube2v1 Tlr4 Ube2n Tlr3 Ly96 Cd14 Ikbkg Mapk11 Mapk14 Ptpn11 Dusp4 ACYL CHAIN REMODELLING OF PI%REACTOME DATABASE ID RELEASE 59%1482922 Acyl chain remodelling of PI Pla2g5 Pla2g4d Pla2g4e Plbd1 Pla2g4f Pla2g4c Mboat7 Pla2g2e Pla2g12a Pla2g2d Pla2g1b Pla2g2f Pla2g4a Pla2g10 Pla2r1 Pla2g16 TCR SIGNALING%REACTOME%R-HSA-202403.4 TCR signaling Btrc Nfkb1 Ptprj Fbxw11 Cd101 Zap70 Ptpn22 Lat Map3k7 Cdc34 Tab2 Pak1 Ripk2 Rela Nfkbia Was Psmd12 Psmd11 Psmd14 Psmd13 Prkcq Psmd10 Ptprc Ube2d1 Traf6 Ikbkb Ube2v1 Ube2n Pak3 Shfm1 Pak2 Ikbkg H2-Aa Trat1 Cd3d Cd3e H2-Eb1 Lck Pten Cd4 Cd3g Psmc6 Psmc5 Pag1 Psmc2 Psmd2 Psmb9 Psmb8 Psmf1 Psme4 Malt1 Card11 Skp1a Csk Psmc1 Psmc4 Psmc3 Pik3cb Cul1 Psme3 Inpp5d Bcl10 Pik3ca Chuk Psma7 Plcg1 Psma5 Psmb5 Psmb4 Ubc Psma4 Psma3 Psmb7 Psma6 Psmb6 Fyb Psmb2 Psmb3 Psma2 Psmb1 Psma1 Nck1 Evl Psmd9 Psmd1 Psme2 Psme1 Vasp Psmd3 Psmd4 Pdpk1 Psmb10 Psmd6 Psmd5 Psmd7 Pik3r1 Psmb11 Psmd8 Grap2 Pik3r2 Itk Lcp2 DEFECTIVE GALNT3 CAUSES FAMILIAL HYPERPHOSPHATEMIC TUMORAL CALCINOSIS (HFTC)%REACTOME DATABASE ID RELEASE 59%5083625 Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC) Muc15 Muc20 Muc1 Muc4 Muc13 RHO GTPASE CYCLE%REACTOME%R-HSA-194840.2 Rho GTPase cycle Akap13 Arhgap11a Depdc7 Ect2 Vav1 Rhof Rhoh Rhoa Rhod Arhgdig Arhgap35 Myo9b Arhgap17 Rac1 Arhgap18 Arhgap12 Arhgap19 Arhgef10l Gmip Arhgap15 Sos2 Racgap1 Fam13b Trio Syde2 Syde1 Dlc1 Ocrl Inpp5b Srgap2 Rhobtb2 Arhgap39 Rhobtb1 Depdc1b Srgap3 Srgap1 Gdi2 Gdi1 Mcf2 Hmha1 Mcf2l Arhgap10 Arhgap22 Arhgap21 Trip10 Myo9a Arhgap20 Arhgap26 Arhgef7 Arhgef11 Arhgap31 Arhgef12 Arhgap32 Arhgap25 Arhgef3 Arhgef4 Arhgef1 Arhgef2 Vav2 Arhgap23 Arhgap29 Arhgap24 Arhgef9 Prex1 Arhgap28 Rac2 Arhgap40 Arhgap42 Arhgap44 Arhgap36 Itsn1 Arhgap33 Ngef Arhgef26 Fgd2 Net1 A2m Fgd4 Fgd1 Fgd3 Stard13 Rhog Arhgef17 Arhgef10 Rhob Vav3 Rhoc Gna13 Plekhg5 Arhgef19 Arhgef16 Arhgef15 Bcr Abr Arhgef18 Plekhg2 Arhgef40 Arap3 Ophn1 Stard8 Arap2 Arap1 Arhgef38 Arhgef39 Rac3 Arhgef37 Tiam2 Tiam1 Kalrn Rhot1 Rhot2 Arhgap8 Arhgap9 Sos1 Arhgap1 Arhgap5 Arhgap4 Arhgdib Arhgap6 Arhgdia Rhoj Arhgef6 Ralbp1 Rhoq Rhou Pik3r2 Rhov PI-3K CASCADE:FGFR1%REACTOME%R-HSA-5654689.2 PI-3K cascade:FGFR1 Fgf23 Fgf22 Fgf20 Frs2 Pik3ca Fgf1 Gab1 Fgf2 Fgf9 Pik3r1 Ptpn11 Fgf10 Fgf6 Fgf4 Fgf3 IRE1ALPHA ACTIVATES CHAPERONES%REACTOME%R-HSA-381070.1 IRE1alpha activates chaperones Arfgap1 Edem1 Syvn1 Gosr2 Preb Ppp2r5b Tln1 Sec63 Klhdc3 Sec62 Yif1a Lmna Zbtb17 Cul7 Serp1 Shc1 Sec61a2 Wipi1 Sec31a Ern1 Acadvl Extl3 Tspyl2 Sec61g Hdgf Sec61a1 Hspa5 Sec61b Gfpt1 Asna1 Add1 Srprb Pdia6 Ssr1 Tpp1 Pdia5 Mydgf Wfs1 Dnajb9 Atp6v0d1 Dnajb11 Tatdn2 Cxxc1 Fkbp14 Ddx11 Srpr Dnajc3 Dctn1 Gsk3a Hyou1 Kdelr3 VITAMIN B2 (RIBOFLAVIN) METABOLISM%REACTOME DATABASE ID RELEASE 59%196843 Vitamin B2 (riboflavin) metabolism Rfk Slc52a3 Acp5 Slc52a2 Enpp1 Flad1 APOPTOSIS%REACTOME%R-HSA-109581.2 Apoptosis Casp9 Prkcd Lmnb1 Ywhae Hist1h1d H1f0 Opa1 Oma1 Bid Mapk8 Ppp3r1 Sptan1 Dcc Fas Casp8 Fadd Apc Tradd Fasl Ripk1 Tnfrsf10b Bmx Tnfsf10 Psmd12 Psmd11 Xiap Psmd14 Casp3 Bcap31 Diablo Tjp1 Casp7 Tjp2 Psmd13 Psmd10 Prkcq Arhgap10 Trp73 Dsg1a Traf2 Acin1 Stk26 Nmt1 Stk24 Dsg3 Dsp Dnm1l Dsg2 Ticam2 Ywhab Dapk2 Birc2 Bcl2 Fnta Ticam1 Bcl2l1 Bak1 Satb1 Gzmb Pkp1 Unc5b Bmf Tlr4 Tlr3 Ly96 Dapk3 Shfm1 Dapk1 Cd14 Pak2 Appl1 Unc5a Hist1h1c Hist1h1e Hist1h1b Hist1h1a Casp6 Gas2 Vim Gsn Psmc6 Trp53bp2 Psmc5 Psmc2 Psmd2 Ppp1r13b Ywhag Clspn Psmb9 Psmf1 Psmb8 Psme4 Bax Bad Dynll2 E2f1 Psmc1 Psmc4 Ptk2 Psmc3 Psme3 Tfdp2 Tfdp1 Trp63 Dynll1 Dbnl Apaf1 Rock1 Ppp3cc Ywhaz Cdh1 Ywhah Sfn Akt2 Akt3 Psma7 Add1 Psma5 Psmb5 Psmb4 Ubc Psma4 Psma3 Psmb7 Psma6 Psmb6 Psmb2 Psmb3 Psma2 Psmb1 Psma1 Akt1 Psmd9 Plec Trp53 Kpnb1 Psmd1 Psme2 Hmgb2 Dffb Psme1 Bcl2l11 Dffa Kpna1 Psmd3 Psmd4 Psmb10 Psmd6 Psmd5 Psmd7 Psmb11 Psmd8 Maged1 MET RECEPTOR RECYCLING%REACTOME DATABASE ID RELEASE 59%8875656 MET receptor recycling Gga3 Rab4a Crkl Gab1 Crk Rab4b Met Arf6 Hgf LATE PHASE OF HIV LIFE CYCLE%REACTOME DATABASE ID RELEASE 59%162599 Late Phase of HIV Life Cycle Gtf2a1 Nup85 Nup160 Gtf2a2 Cdk9 Gtf2b Xpo1 Taf1 Taf2 Taf4b Taf7 Taf4a Rngtt Taf5 Taf6 Rnmt Taf3 Polr2i Gtf2e1 Polr2j Nelfa Gtf2e2 Nelfb Polr2c Mnat1 Polr2d Supt4a Polr2b Taf9 Polr2g Ccnt1 Ctdp1 Nedd4l Nup107 Polr2a Nelfe Supt5 Nelfcd Gtf2f1 Ccnt2 Ncbp1 Ncbp2 Gtf2f2 Chmp5 Chmp7 Taf13 Chmp6 Taf11 Chmp3 Vps37d Rcc1 Vps37c Nup37 Vps37b Pdcd6ip Tonsl Nup43 Vps4b Nup133 Vps4a Vta1 Chmp2a Chmp4c Chmp4b Ercc3 Nmt2 Vps37a Ranbp1 Nmt1 Taf12 Ercc2 Tsg101 Ranbp2 Nup50 Tpr Ndc1 Nup214 Aaas Nup210 Nup188 Nup54 Nup35 Nupl2 Nup62 Nup205 Nup155 Nup88 Pom121 Rae1 Polr2f Polr2e Polr2h Tbp Nup93 Ell Nup153 Taf9b Polr2k Furin Ssrp1 Ran Gtf2h1 Gtf2h2 Gtf2h5 Gtf2h4 Gtf2h3 Ubc Ppia Tcea1 Ak6 Tceb1 Tceb3 Supt16 Ccnh Ccnk Cdk7 TAT-MEDIATED HIV ELONGATION ARREST AND RECOVERY%REACTOME%R-HSA-167243.2 Tat-mediated HIV elongation arrest and recovery Cdk9 Polr2i Polr2f Polr2j Polr2e Nelfa Polr2h Nelfb Ell Polr2c Polr2d Supt4a Polr2b Tcea1 Tceb1 Tceb3 Supt16 Polr2k Polr2g Ccnt1 Ctdp1 Ssrp1 Polr2a Nelfe Supt5 Nelfcd Gtf2f1 Gtf2f2 MISCELLANEOUS TRANSPORT AND BINDING EVENTS%REACTOME%R-HSA-5223345.2 Miscellaneous transport and binding events Pip Add1 Dmtn Azgp1 Magt1 Pqlc2 Tusc3 Nipal4 Mrs2 Nipal1 Nipal2 Mmgt1 Nipal3 Ank Nipa2 Add3 Add2 Ctns Nipa1 ACTIVATION OF BIM AND TRANSLOCATION TO MITOCHONDRIA%REACTOME DATABASE ID RELEASE 59%111446 Activation of BIM and translocation to mitochondria Mapk8 Dynll1 Bcl2l11 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 27-HYDROXYCHOLESTEROL%REACTOME DATABASE ID RELEASE 59%193807 Synthesis of bile acids and bile salts via 27-hydroxycholesterol Akr1c6 Cyp7a1 Cyp7b1 Rxra Nr1h4 Ptgis Akr1c18 Cyp27a1 Akr1d1 Hsd3b7 Akr1c21 Ncoa1 Cyp8b1 Ncoa2 RA BIOSYNTHESIS PATHWAY%REACTOME DATABASE ID RELEASE 59%5365859 RA biosynthesis pathway Cyp26c1 Cyp26a1 Aldh8a1 Aldh1a3 Crabp1 Cyp26b1 Rdh5 Adh1 Rdh13 Rdh14 Aldh1a2 Adh4 Dhrs3 Dhrs4 Rdh10 Akr1c18 Dhrs9 BC089597 Sdr16c5 Rdh11 Aldh1a1 PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR%REACTOME%R-HSA-392851.2 Prostacyclin signalling through prostacyclin receptor Gngt1 Gng7 Gng4 Ptgir Gngt2 Gng10 Gng11 Gng13 Gng12 Gnb2 Gnb1 Gnb3 Gnb5 Gnb4 Gng8 Gng3 Gng2 PACKAGING OF TELOMERE ENDS%REACTOME DATABASE ID RELEASE 59%171306 Packaging Of Telomere Ends H2afb2 Hist1h2bg Tinf2 Pot1a Hist1h2bh Hist2h2aa1 Terf1 Terf2 Hist1h2bp Hist1h2bm Acd Hist1h2bj Hist1h2bb Hist1h3h Hist1h2ak Hist3h2ba Hist2h2be Hist1h2ag H2afz Terf2ip Hist2h2ac H2afx Hist1h2ah H2afj CALMODULIN INDUCED EVENTS%REACTOME DATABASE ID RELEASE 59%111933 Calmodulin induced events Adcy7 Adcy6 Creb1 Prkcd Adcy5 Adcy4 Adcy3 Adcy2 Prkcg Prkar2a Adcy1 Prkacb Pde1c Camk4 Pde1b Adcy9 Pde1a Adcy8 Prkca Prkar2b Prkar1a Prkar1b Prkaca Adrbk1 FORMATION OF THE EDITOSOME%REACTOME DATABASE ID RELEASE 59%75094 Formation of the Editosome Apobec3 A1cf Apobec2 Apobec1 Apobec4 SYNTHESIS OF PE%REACTOME DATABASE ID RELEASE 59%1483213 Synthesis of PE Chkb Lpin2 Etnk1 Etnppl Ept1 Lpin3 Cept1 Lpin1 Phospho1 Pcyt2 Pisd Chka COMPLEX I BIOGENESIS%REACTOME%R-HSA-6799198.1 Complex I biogenesis Ndufs5 Ndufs4 Ndufa13 Ndufs2 Ndufb11 Ndufb10 Ndufs7 Ndufs8 Ndufa11 Ndufs1 Ndufa10 Ndufa12 Ndufb2 Acad9 Ndufc2 Ndufc1 Ndufb4 Ecsit Ndufb3 Ndufb6 Ndufb5 mt-Nd2 mt-Nd1 Timmdc1 Nubpl mt-Nd6 mt-Nd5 mt-Nd4 mt-Nd3 Ndufaf1 Ndufaf2 Ndufaf3 Ndufa1 Ndufa2 Ndufa3 Ndufa5 Ndufaf4 Ndufb9 Ndufb7 Yjefn3 Ndufb8 Tmem126b Ndufv3 Ndufv1 Ndufv2 Ndufab1 Ndufa6 Ndufa7 Ndufaf5 Ndufaf6 Ndufa8 Ndufa9 Ndufaf7 SPERM MOTILITY AND TAXES%REACTOME DATABASE ID RELEASE 59%1300642 Sperm Motility And Taxes Kcnu1 Hvcn1 Catsperg1 Catsperd Catsper1 Catsper2 Catsper3 Catsperb Catsper4 MET ACTIVATES PTPN11%REACTOME%R-HSA-8865999.1 MET activates PTPN11 Gab1 Met Ptpn11 Hgf FUSION OF THE INFLUENZA VIRION TO THE HOST CELL ENDOSOME%REACTOME DATABASE ID RELEASE 59%168288 Fusion of the Influenza Virion to the Host Cell Endosome SCAVENGING BY CLASS H RECEPTORS%REACTOME DATABASE ID RELEASE 59%3000497 Scavenging by Class H Receptors Sparc Stab2 Apob Stab1 SENSING OF DNA DOUBLE STRAND BREAKS%REACTOME DATABASE ID RELEASE 59%5693548 Sensing of DNA Double Strand Breaks Mre11a Nbn Atm Kat5 Rad50 SIGNALLING TO P38 VIA RIT AND RIN%REACTOME DATABASE ID RELEASE 59%187706 Signalling to p38 via RIT and RIN Akap9 Ppp2r1a Csf2 Jak1 Frs2 Nras Frs3 Rasgrf1 Psmf1 Raf1 Psme4 Il5ra Fgf1 Il17rd Fgf2 Cnksr1 Csk Cnksr2 Erbb2 Fgf9 Ptk2 Fgf7 Psme3 Fgf6 Fgf4 Fgf3 Ppp5c Ranbp9 Ppp2cb Shc1 Lamtor2 Nrg2 Ppp2ca Shc3 Nrg1 Shc2 Psma7 Artn Nrtn Brap Psmb5 Psmb4 Ubc Nrg3 Psmb7 Nrg4 Psmb6 Psmb2 Psmb3 Psmb1 Mapk3 Mapk1 Ksr1 Ptpra Dusp16 Dusp10 Map3k11 Paqr3 Psme2 Psme1 Ncam1 Sos1 Braf Psmb10 Apbb1ip Psmb11 Csf2rb2 Rapgef2 Csf2ra Actn2 Nf1 Pdgfrb Pdgfra Kbtbd7 Il2rg Arrb2 Egfr Arrb1 Ret Ntrk1 Vwf Sptan1 Pspn Map2k1 Rbx1 Fgg Map2k2 Cul3 Psmd12 Pdgfb Psmd11 Rasgef1a Psmd14 Rasa3 Rasa4 Psmd13 Psmd10 Il2 Rasa2 Rasa1 Nefl Spred3 Kit Spred2 Grin2a Spred1 Spta1 Il5 Ppp2r1b Sptbn4 Ywhab Kras Gdnf Shfm1 Irs2 Syngap1 Hbegf Irs1 Il3ra Btc Il2ra Il2rb Angpt1 Psmc6 Egf Fgf23 Psmc5 Fgf22 Mark3 Psmc2 Fgf20 Psmd2 Dab2ip Tek Psmb9 Psmb8 Araf Hras Grin1 Ppp2r5e Dlg4 Ppp2r5c Ppp2r5d Ppp2r5a Psmc1 Psmc4 Psmc3 Sptbn2 Itgb3 Sptbn1 Fyn Phb Grin2c Rasgrp4 Rasgrp3 Pebp1 Ppp2r5b Rasgrp1 Tln1 Fga Fgb Grin2d Grin2b Sptb Hgf Gfra2 Gfra3 Gfra4 Ereg Jak2 Pea15a Itga2b Rap1a Jak3 Wdr83 Camk2d Rap1b Camk2a Fgfr4 Camk2b Psma5 Rasal3 Rasal2 Psma4 Psma3 Psma6 Vcl Camk2g Psma2 Psma1 Gfra1 Rit2 Psmd9 Ngf Dusp7 Iqgap1 Rit1 Fgf16 Dusp6 Dusp9 Fgf15 Dusp8 Klb Fgf18 Psmd1 Met Fn1 Rasal1 Dusp1 Psmd3 Psmd4 Psmd6 Psmd5 Dusp2 Psmd7 Dusp5 Psmd8 Fgf10 Dusp4 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE%REACTOME DATABASE ID RELEASE 59%168138 Toll Like Receptor 9 (TLR9) Cascade Rbsn Irf7 Pik3c3 Ppp2r1a Pik3r4 Btrc Mapk9 Nfkb2 Nfkb1 Ecsit Fbxw11 Skp1a Saa3 Ppp2r5d Tlr8 Mapkapk3 Tlr7 Tnip2 Myd88 Nod2 Cul1 Nod1 Dhx9 Vrk3 S100b Elk1 Mef2c Mapk10 Mef2a Dusp3 Map3k7 Mapk7 Peli1 Creb1 Mapkapk2 Irak2 Irak1 App Map2k6 Tab1 Tab2 Jun Mapk8 Tab3 Map3k1 Ripk2 Map2k7 Ager Dhx36 Map2k3 Map2k4 Map3k8 Rela Atf2 Nfkbia Peli3 Nfkbib Irak4 Fos Peli2 Ppp2cb Map2k1 Chuk Tlr9 Ppp2ca Eea1 Ubc Mapk3 Rps6ka5 Mapk1 Ppp2r1b Ticam2 Dusp7 Rps6ka3 Dusp6 Rps6ka2 Ticam1 Rps6ka1 Traf6 Ikbkb Ube2v1 Tlr4 Ube2n Tlr3 Ly96 Cd14 Ikbkg Mapk11 Mapk14 Dusp4 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING%REACTOME DATABASE ID RELEASE 59%163210 Formation of ATP by chemiosmotic coupling Atp5g3 Atp5k Atp5j mt-Atp6 Atp5b Atp5s Atp5d Atp5j2 Atp5c1 Atp5f1 Atp5a1 RIPK1-MEDIATED REGULATED NECROSIS%REACTOME DATABASE ID RELEASE 59%5213460 RIPK1-mediated regulated necrosis Fas Casp8 Fadd Ripk3 Tradd Birc3 Birc2 Fasl Ripk1 Tnfrsf10b Tnfsf10 Mlkl Xiap Traf2 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B%REACTOME DATABASE ID RELEASE 59%174048 APC C:Cdc20 mediated degradation of Cyclin B Cdc23 Ube2d1 Cdc27 Cdc16 Cdc20 Ube2c Anapc16 Ube2e1 Anapc7 Anapc4 Anapc5 Anapc1 Anapc2 Ubc Cdk1 Anapc15 Anapc11 Anapc10 TNFR1-MEDIATED CERAMIDE PRODUCTION%REACTOME%R-HSA-5626978.1 TNFR1-mediated ceramide production Smpd3 Tnf Gnb2l1 Nsmaf Tnfrsf1a Smpd2 THE NLRP1 INFLAMMASOME%REACTOME%R-HSA-844455.1 The NLRP1 inflammasome Bcl2 Bcl2l1 Nlrp1a VASOPRESSIN-LIKE RECEPTORS%REACTOME%R-HSA-388479.1 Vasopressin-like receptors Oxt Avp Avpr1a Avpr2 Avpr1b Oxtr T41 MUTANTS OF BETA-CATENIN AREN'T PHOSPHORYLATED%REACTOME DATABASE ID RELEASE 59%5358752 T41 mutants of beta-catenin aren't phosphorylated Ppp2cb Ppp2r1b Apc Axin1 Ppp2ca Amer1 Csnk1a1 Ctnnb1 Gsk3b Ppp2r1a Ppp2r5b Ppp2r5e Ppp2r5c Ppp2r5d Ppp2r5a GAP JUNCTION ASSEMBLY%REACTOME DATABASE ID RELEASE 59%190861 Gap junction assembly Gjd2 Gjb1 Gjd3 Gjb2 Gjd4 Gja1 Gjb4 Gjb3 Gja10 Gjc1 Gja8 Gja3 Gja5 Gjb6 Gjb5 Gja4 Gjc2 ACTIVATION OF NOXA AND TRANSLOCATION TO MITOCHONDRIA%REACTOME DATABASE ID RELEASE 59%111448 Activation of NOXA and translocation to mitochondria Trp53 E2f1 Tfdp2 Tfdp1 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%R-HSA-2514859.2 Inactivation, recovery and regulation of the phototransduction cascade Grk1 Gngt1 Pde6g Camkmt Prkca Prkcq Nmt2 Rho Nmt1 Fnta Gnat1 Pde6a Gucy2e Rcvrn Gnb1 Pde6b Gucy2f Cnga1 Rgs9bp Fntb Guca1a Sag Guca1b Ppef1 Metap2 Metap1 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION)%REACTOME%R-HSA-70614.4 Amino acid synthesis and interconversion (transamination) Asns Pycr2 Pycr1 Got1 Oat Glud1 Pycrl Aspg Psat1 Naalad2 Phgdh Gls2 Serinc5 Serinc4 Aspa Serinc3 Psph Gpt Serinc1 Serinc2 Gadl1 Glul Gls Ccbl1 Got2 HYPUSINYLATION%REACTOME%R-HSA-204626.1 Hypusinylation Eif5a2 Eif5a Dohh Dhps FREE FATTY ACIDS REGULATE INSULIN SECRETION%REACTOME%R-HSA-400451.1 Free fatty acids regulate insulin secretion Plcb3 Gna11 Gnaq Plcb1 Gna15 Plcb2 Ffar1 Gna14 RNA POLYMERASE I PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 59%73772 RNA Polymerase I Promoter Escape Gtf2h5 Gtf2h4 Cd3eap Gtf2h3 Ercc3 Polr1a Polr1e Znrd1 Taf1d Taf1c Taf1b Taf1a Ercc2 Polr2f Polr2e Polr2h Tbp Mnat1 Ubtf Polr1b Rrn3 Polr2k Ccnh Cdk7 Polr1d Polr1c Gtf2h1 Gtf2h2 ACTIVATION OF SMO%REACTOME DATABASE ID RELEASE 59%5635838 Activation of SMO Gas1 Gas8 Evc2 Boc Smo Evc Iqce Csnk1a1 Kif3a Cdon Ptch1 Arrb2 Arrb1 Adrbk1 Ihh Shh Dhh NADE MODULATES DEATH SIGNALLING%REACTOME DATABASE ID RELEASE 59%205025 NADE modulates death signalling Casp3 Ngf Ywhae Casp2 Ngfr Ngfrap1 AMYLOID FIBER FORMATION%REACTOME DATABASE ID RELEASE 59%977225 Amyloid fiber formation Nat8 Usp9x Sorl1 Siah1a Ube2l6 Hist2h3c1 Apoa4 Saa3 Siah2 Apcs Iapp H2afb2 Calb1 Ins2 App Tgfbi Cst3 Sncaip Furin Hist2h2be Hist3h2ba Fga Hist2h2ac Apoa1 H3f3b H3f3a Hist1h2bg Hist1h2bh Ltf Hist1h2bp Hist1h2bm Prl Hist1h2bj Bace1 Hist1h2bb Ttr Mfge8 Ubc H2afz H2afx Itm2b Gga2 Gga3 Snca Hist2h2aa1 Odam Hist1h3d Nppa Hist1h2ak Park2 Hist1h2ag B2m Hist1h2ah Hspg2 Gga1 Gsn XAV939 INHIBITS TANKYRASE, STABILIZING AXIN%REACTOME%R-HSA-5545619.1 XAV939 inhibits tankyrase, stabilizing AXIN Tnks2 Tnks SIGNAL REGULATORY PROTEIN (SIRP) FAMILY INTERACTIONS%REACTOME DATABASE ID RELEASE 59%391160 Signal regulatory protein (SIRP) family interactions Sirpa Skap2 Tyrobp Sirpb1b Fyb Ptpn6 Ptk2 Ptpn11 Ptk2b Cd47 G ALPHA (12 13) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 59%416482 G alpha (12 13) signalling events Gngt1 Gng7 Akap13 Gng4 Tbxa2r Gngt2 Gng10 Ect2 Vav1 Rhoa Rac1 Ngef Arhgef10l Gng11 Pik3ca Gng13 Sos2 Arhgef26 Gng12 Fgd2 Net1 Gnb2 Gnb1 Gnb3 Fgd4 Gnb5 Fgd1 Trio Gnb4 Fgd3 Gna12 Rhog Gng8 Arhgef17 Arhgef10 Rhob Vav3 Rock1 Gng3 Rhoc Gng2 Gna13 Rock2 Plekhg5 Arhgef19 Adra1a Arhgef16 Adra1b Arhgef15 Abr Adra1d Arhgef18 Plekhg2 Arhgef40 Arhgef38 Arhgef39 Mcf2 Mcf2l Arhgef37 Tiam2 Tiam1 Arhgef7 Arhgef11 Arhgef12 Arhgef3 Arhgef4 Kalrn Arhgef1 Arhgef2 Vav2 Plxnb1 Arhgef9 Sos1 Prex1 Rac2 Pik3r3 Arhgef6 Pik3r1 Itsn1 Pik3r2 G2 M CHECKPOINTS%REACTOME DATABASE ID RELEASE 59%69481 G2 M Checkpoints Ywhae Trex1 Rfc5 Mcm6 Rfc3 Mcm3 Mcm2 Mcm5 Mcm4 Rfc2 Rfc4 Orc4 Orc5 Mcm8 Mcm7 Nbn Cdc45 Atrip Dna2 Bard1 Orc2 Orc3 Orc6 Orc1 Chek2 Rpa2 Mre11a Rpa1 Atm Hist2h2be Rpa3 Rad17 Hist1h2bg Hist1h2bh Hist1h2bp Hist1h2bm Rbbp8 Psmd12 Psmd11 Hist1h2bj Hist1h2bb Psmd14 Rad1 Psmd13 Psmd10 Ywhab Kat5 Ube2n Shfm1 Psmc6 Psmc5 Psmc2 Fam175a Psmd2 Pias4 Ywhag Clspn Psmb9 Psmf1 Psmb8 Rnf168 Psme4 Ube2v2 Cdc6 Cdk2 Cdk1 Brcc3 Rad50 Psmc1 Trp53bp1 Psmc4 Psmc3 Uimc1 Cdc25a Psme3 Babam1 Ccnb2 Gtse1 Pkmyt1 Hist3h2ba Top3a Chek1 Wee1 Ywhaz Cdc25c Ywhah Sfn Topbp1 Psma7 Psma5 Rad9a Psmb5 Blm Psmb4 Ubc Psma4 Rad9b Psma3 Psmb7 Psma6 Hus1 Psmb6 Cdc7 Psmb2 Mdc1 Psmb3 Psma2 Dbf4 Psmb1 H2afx Mcm10 Psma1 Exo1 Brip1 Psmd9 Herc2 Bre Trp53 Wrn Psmd1 Psme2 Whsc1 Hist1h3h Psme1 Brca1 Psmd3 Psmd4 Psmb10 Psmd6 Psmd5 Psmd7 Psmb11 Psmd8 COPII (COAT PROTEIN 2) MEDIATED VESICLE TRANSPORT%REACTOME DATABASE ID RELEASE 59%204005 COPII (Coat Protein 2) Mediated Vesicle Transport Sar1b Stx5a Ppp6c Sec23a Trappc10 Sec23ip Golga2 Gosr2 Trappc2l Trappc2 Tgfa Trappc3 Mcfd2 Trappc1 Rab1 F5 Csnk1d Preb F8 Sec24a Sec24b Sec13 Tbc1d20 Sec24d Scfd1 Gria1 Sec24c Sec16b Sec22a Lman1 Sec22b Tfg Lman2 Ykt6 Sec16a Cd59b Sec22c Lman2l Sec31a Gorasp1 Nsf Trappc6a Trappc6b Ankrd28 Trappc9 Napb Napg Napa Trappc5 Trappc4 Ctsz Serpina1d Col7a1 Lman1l Areg Serpina1a Folr1 Rab1b Ppp6r1 Ppp6r3 Cnih1 Uso1 Bet1 Stx17 Cnih3 Ctsc Cnih2 NUCLEOSOME ASSEMBLY%REACTOME DATABASE ID RELEASE 59%774815 Nucleosome assembly Hist1h2bg Hist1h2bh Smarca5 Mis18bp1 Cenpw Hist1h2bp Hist1h2bm Ruvbl1 Hist1h2bj Stra13 Mis18a Itgb3bp Rbbp7 Hist1h2bb Oip5 Rsf1 Cenpu H2afz Casc5 Rbbp4 H2afx Cenpa H2afj Cenpc1 H2afb2 Cenpq Cenpp Hist2h2aa1 Cenpm Cenpl Cenpo Npm1 Cenpn Cenpt Apitd1 Hist1h2ak Hist2h2be Hist3h2ba Hist1h2ag Hist2h2ac Cenph Cenpi Hist1h2ah Cenpk CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA%REACTOME%R-HSA-1834949.1 Cytosolic sensors of pathogen-associated DNA Prkdc Irf7 Tmem173 Xrcc5 Tbk1 Ddx41 Xrcc6 Nlrp4e Nlrc3 Dtx4 Irf3 Trex1 Nfkb2 Trim21 Nfkb1 Saa3 Myd88 Mb21d1 Dhx9 Trim32 S100b Zbp1 Trim56 Polr2f Polr2e Polr2h App Stat6 Dhx36 Ager Polr2k Rela Crcp Polr3a Polr3gl Crebbp Nfkbia Polr3k Mre11a Polr3h Nfkbib Polr3f Polr3g Ep300 Polr1d Polr1c Polr3d Polr3e Polr3b Polr3c Chuk Ripk1 Ctnnb1 Ubc Ripk3 Ticam1 Ikbkb Tlr3 Ikbkg SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1%REACTOME DATABASE ID RELEASE 59%174113 SCF-beta-TrCP mediated degradation of Emi1 Psmc6 Psmc5 Psmc2 Psmd2 Psmb9 Psmb8 Psmf1 Psme4 Btrc Skp1a Psmc1 Psmc4 Psmc3 Cul1 Psme3 Fzr1 Fbxo5 Psmd12 Psma7 Psmd11 Psmd14 Psma5 Psmb5 Psmb4 Psmd13 Ubc Psmd10 Psma4 Psma3 Psmb7 Psma6 Psmb6 Psmb2 Psmb3 Psma2 Psmb1 Psma1 Psmd9 Cdc20 Psmd1 Shfm1 Psme2 Psme1 Psmd3 Psmd4 Psmb10 Psmd6 Psmd5 Psmd7 Psmb11 Psmd8 PYRIMIDINE SALVAGE REACTIONS%REACTOME%R-HSA-73614.2 Pyrimidine salvage reactions Tymp Upp2 Cda Upp1 Dck Tk1 Hdhd1a Uck1 Tk2 Uck2 PHOSPHOLIPASE C-MEDIATED CASCADE; FGFR3%REACTOME%R-HSA-5654227.2 Phospholipase C-mediated cascade; FGFR3 Fgf1 Fgf23 Fgf16 Fgf2 Fgf20 Fgf18 Fgf9 Fgf4 Plcg1 AUTODEGRADATION OF CDH1 BY CDH1:APC C%REACTOME DATABASE ID RELEASE 59%174084 Autodegradation of Cdh1 by Cdh1:APC C Psmc6 Psmc5 Psmc2 Psmd2 Psmb9 Psmb8 Psmf1 Psmc1 Psmc4 Psmc3 Anapc15 Psme3 Anapc11 Anapc10 Fzr1 Psmd12 Psma7 Psmd11 Psmd14 Psma5 Psmb5 Psmb4 Psmd13 Ubc Psmd10 Psma4 Psmb7 Psma3 Psma6 Psmb6 Psmb2 Psmb3 Psmb1 Psma2 Psma1 Psmd9 Cdc23 Ube2d1 Cdc27 Cdc16 Ube2c Anapc16 Ube2e1 Psmd1 Anapc7 Shfm1 Psme2 Anapc4 Anapc5 Psme1 Anapc1 Anapc2 Psmd3 Psmd4 Psmb10 Psmd6 Psmd5 Psmd7 Psmd8 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION%REACTOME DATABASE ID RELEASE 59%2173796 SMAD2 SMAD3:SMAD4 heterotrimer regulates transcription Serpine1 Cdk9 Ccnc Cdk8 Sp1 Rbl1 Ubc E2f5 Myc E2f4 Hdac1 Atp1b4 Wwtr1 Tgif2 Tgif1 Tfdp2 Cdkn2b Rnf111 Tfdp1 Junb Smad4 Smad2 Smad7 Smad3 Ccnt1 Ccnk Men1 Ccnt2 ANTIMICROBIAL PEPTIDES%REACTOME DATABASE ID RELEASE 59%6803157 Antimicrobial peptides Prtn3 Pdzd11 Defb47 Atox1 Lcn2 Camp Ltf Bpifb2 Bpifb1 Bpifb6 S100a9 Tlr2 S100a8 Leap2 Defb25 Rnase2b Atp7a Ccr6 Chga Clu Itln1 Defb18 Bpi Gm15386 Pglyrp3 Defb36 Pglyrp4 Ccr2 Prss2 Pglyrp2 Eppin Art1 Defb29 Pglyrp1 Rnase6 Bpifa1 Ctsg Defb15 Reg3g Defb19 Defb14 Defb23 Bpifa2 Elane Defb12 Reg3b Slc11a1 Cd4 Tlr1 CLEAVAGE OF THE DAMAGED PYRIMIDINE%REACTOME%R-HSA-110329.1 Cleavage of the damaged pyrimidine Nthl1 Ogg1 Neil1 Mbd4 Neil2 Smug1 MAP KINASE ACTIVATION IN TLR CASCADE%REACTOME DATABASE ID RELEASE 59%450294 MAP kinase activation in TLR cascade Ppp2r1a Btrc Mapk9 Nfkb1 Fbxw11 Skp1a Ppp2r5d Mapkapk3 Tnip2 Nod2 Cul1 Nod1 Vrk3 Elk1 Mef2c Mapk10 Mef2a Map3k7 Dusp3 Creb1 Mapk7 Irak2 Mapkapk2 Irak1 Tab1 Map2k6 Tab2 Jun Tab3 Mapk8 Ripk2 Map2k7 Map2k3 Map2k4 Map3k8 Atf2 Fos Ppp2cb Map2k1 Chuk Ppp2ca Ubc Mapk3 Rps6ka5 Mapk1 Ppp2r1b Dusp7 Rps6ka3 Rps6ka2 Dusp6 Rps6ka1 Traf6 Ikbkb Ube2v1 Ube2n Ikbkg Mapk11 Mapk14 Dusp4 VEGFR2 MEDIATED CELL PROLIFERATION%REACTOME DATABASE ID RELEASE 59%5218921 VEGFR2 mediated cell proliferation Akap9 Ppp2r1a Prkcb Csf2 Jak1 Frs2 Nras Frs3 Rasgrf1 Psmf1 Raf1 Psme4 Il5ra Fgf1 Il17rd Fgf2 Cnksr1 Csk Cnksr2 Erbb2 Fgf9 Ptk2 Fgf7 Psme3 Fgf6 Fgf4 Fgf3 Ppp5c Ranbp9 Ppp2cb Shc1 Lamtor2 Nrg2 Ppp2ca Shc3 Nrg1 Shc2 Psma7 Artn Nrtn Plcg1 Brap Psmb5 Psmb4 Ubc Nrg3 Psmb7 Nrg4 Psmb6 Psmb2 Psmb3 Psmb1 Mapk3 Mapk1 Ksr1 Ptpra Dusp16 Dusp10 Map3k11 Paqr3 Psme2 Psme1 Ncam1 Sos1 Braf Psmb10 Apbb1ip Ahcyl1 Psmb11 Csf2rb2 Rapgef2 Csf2ra Prkcd Actn2 Nf1 Pdgfrb Pdgfra Kbtbd7 Prkca Il2rg Arrb2 Egfr Arrb1 Ret Vwf Sptan1 Pspn Map2k1 Rbx1 Fgg Map2k2 Cul3 Psmd12 Pdgfb Psmd11 Rasgef1a Psmd14 Rasa3 Rasa4 Psmd13 Psmd10 Il2 Rasa2 Rasa1 Nefl Spred3 Kit Spred2 Kdr Grin2a Spred1 Spta1 Il5 Ppp2r1b Sptbn4 Ywhab Kras Gdnf Shfm1 Itpr1 Irs2 Syngap1 Hbegf Irs1 Il3ra Btc Il2ra Il2rb Itpr3 Angpt1 Itpr2 Psmc6 Egf Fgf23 Psmc5 Fgf22 Mark3 Psmc2 Fgf20 Psmd2 Dab2ip Tek Psmb9 Psmb8 Araf Hras Grin1 Sphk1 Ppp2r5e Dlg4 Ppp2r5c Ppp2r5d Ppp2r5a Psmc1 Psmc4 Psmc3 Sptbn2 Sptbn1 Itgb3 Fyn Phb Grin2c Rasgrp4 Rasgrp3 Pebp1 Ppp2r5b Rasgrp1 Tln1 Fga Fgb Grin2d Grin2b Sptb Hgf Gfra2 Gfra3 Gfra4 Ereg Jak2 Pea15a Itga2b Rap1a Jak3 Wdr83 Camk2d Rap1b Camk2a Fgfr4 Camk2b Psma5 Rasal3 Rasal2 Psma4 Psma3 Psma6 Vcl Camk2g Psma2 Psma1 Gfra1 Psmd9 Dusp7 Iqgap1 Fgf16 Dusp6 Dusp9 Fgf15 Dusp8 Klb Fgf18 Psmd1 Met Prkcz Fn1 Rasal1 Dusp1 Psmd3 Psmd4 Pdpk1 Psmd6 Psmd5 Dusp2 Psmd7 Dusp5 Psmd8 Fgf10 Dusp4 CLEC7A INFLAMMASOME PATHWAY%REACTOME DATABASE ID RELEASE 59%5660668 CLEC7A inflammasome pathway Casp8 Malt1 Nfkb1 Pycard Il1b Rela RAB GEFS EXCHANGE GTP FOR GDP ON RABS%REACTOME%R-HSA-8876198.2 RAB GEFs exchange GTP for GDP on RABs Gapvd1 Trappc11 Dennd6b Trappc12 Trappc13 Rab3il1 Dennd1b Dennd6a Rinl Dennd3 Rgp1 Rabgef1 Rab5c Ywhae Dennd1c Rab5b Rab3ip Dennd4c Trappc8 Hps1 Rab8a Rab39 Hps4 Trappc10 Rin2 Rin3 Dennd2a Rin1 St5 Dennd1a Dennd2d Trappc2l Dennd2c Rab14 Trappc2 Trappc3 Rab38 Trappc1 Rab1 Rab32 Rab31 Rab12 Rab13 Rab27a Rab10 Rab35 Rab21 Rab3gap1 Akt2 Rab5a Akt3 Rab27b Trappc6a Rab9 Trappc6b Gdi2 Gdi1 Chm Trappc9 Akt1 Trappc5 Rab39b Trappc4 Chml Als2cl Sbf1 Rab8b Sbf2 Dennd5a Dennd5b Rab7 Mon1a Mon1b Als2 Ulk1 Ankrd27 Dennd4a Ric1 Dennd4b Rab1b Rab9b Rab18 Rab3a Rab6b Rab6a POST NMDA RECEPTOR ACTIVATION EVENTS%REACTOME%R-HSA-438064.1 Post NMDA receptor activation events Actn2 Adcy3 Camkk1 Adcy1 Akap9 Prkacb Camk2d Rasgrf1 Camk2a Adcy8 Camk2b Hras Raf1 Grin1 Dlg4 Nefl Camk2g Grin2a Mapk1 Creb1 Rps6ka6 Rps6ka3 Grin2c Rps6ka2 Rps6ka1 Rras Camk4 Braf Pdpk1 Grin2d Prkaca Grin2b INTERCONVERSION OF POLYAMINES%REACTOME DATABASE ID RELEASE 59%351200 Interconversion of polyamines Sat1 Paox CREATINE METABOLISM%REACTOME%R-HSA-71288.1 Creatine metabolism Slc6a11 Slc6a8 Gatm Ckmt2 Slc6a12 Ckmt1 Gamt Ckm Ckb Slc6a7 IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 59%168256 Immune System Prkcb Hspa1a Cul7 Vegfa Slc2a5 Csk Cd274 Slc2a3 Pgm1 Dera Adam10 Gab2 Itch Wwp1 Nedd4 Adam17 Nlrc4 Map2k6 Mre11a S100a1 Cd180 S100a9 S100a8 Eea1 Ly86 Ptpn4 Itgb2 Bpi Itgam Junb H2-Aa Cd3d Cd3e H2-Eb1 Lck Park2 Pdcd1lg2 Cd4 Ptpn6 Casp1 Gyg Casp2 Pdcd1 Ptpn11 Cd3g Alad Hmox1 Hmox2 Hsp90aa1 Prkar2b Bcl6 Cnpy3 Pin1 Unc93b1 Rnf111 Tubb4b Dynll1 Atf2 Crebbp Idh1 Actr1a Apaf1 Fos Prkaca Dync1i2 Dctn2 Dctn3 Tubb5 Hspa5 Dync1h1 Ube2d3 Dnajc3 Mmp1a Timp2 Ctss Smurf1 Ctsg Ctsb Ctsk Ctsl Stub1 Ctsd Slc11a1 Nos1 Nos2 Mmp3 Cd44 Mmp8 Ckap4 Trex1 Fbxo4 Fbxo6 Cdk13 Rnf34 Jun Rab31 Nedd4l Rab10 Ep300 Rab24 Pml Ube2z Ube2w Glb1 Ube2k Ube2h Fbxl5 Fbxl3 Rorc Rora Lamtor1 Txn1 Myc Tceb1 Gpi1 Smurf2 Ppie Apeh Eef2 Adar Prkdc Pik3c3 Tmem173 Xrcc5 Tbk1 Ddx41 Xrcc6 Iqgap2 Nlrp4e Actb Nlrc3 Pik3r4 Dtx4 Wipf3 Wipf2 Rhof Wipf1 Wasf2 Wasf3 Arpc5 Arpc4 Wasf1 Diap1 Myo9b Cybb Cyba Klc3 Klc2 Klc4 Racgap1 Was Actg1 Gdi2 Hmha1 Nckap1l Klc1 Abi1 Abi2 Aldoc Aldoa Arpc1a Arpc1b Hist1h3d Nckap1 Pfkl Pgam1 Cyfip1 Pgm2 Cyfip2 Nup50 Tpr Ndc1 Ncf4 Nup214 Hist2h3c1 Aaas Nup210 Nup188 Ncf2 Nup54 Ncf1 Nup35 Nupl2 Nup62 Nup205 Nup155 Nup88 Pom121 Rae1 Nup93 Nup153 Fbxl7 Fbxl18 Tlr9 Snap25 Rab3a Stx1a Casp9 Prkcd Prkce Actn2 Nf1 Prkcg Tsc2 Pdgfrb Stat5b Pdgfra Stat5a Mlst8 Kbtbd7 Prkca Vav1 Il2rg Ikbke Tank Arrb2 Egfr Traf3 Gab1 Arrb1 Mtor Ret Phlpp1 Adrbk1 Vwf Phlpp2 Sox2 Mmp2 Mmp9 Pspn Map2k1 Rbx1 Crkl Fgg Cdkn1a Map2k2 Cul3 Psmd12 Pdgfb Psmd11 Rasgef1a Igf2r Psmd14 Rasa3 Rasa4 Psmd13 Psmd10 Il2 Rasa2 Rasa1 Nefl Spred3 Kit Spred2 Pafah1b2 Grin2a Spred1 Il5 Ppp2r1b Ywhab Ago2 Ago1 Tnrc6c Kras Insr Gsk3a Gsk3b Tnrc6b Gdnf Shfm1 Tnrc6a Ago4 Ago3 Itpr1 Trat1 Surf4 Irs2 Rab9b Mdm2 Syngap1 Pten Hbegf Rab18 Irs1 Il3ra Btc Il2ra Il2rb Rab6a Itpr3 Angpt1 Itpr2 Trib3 Psmc6 Egf Agl Fgf23 Psmc5 Pag1 Fgf22 Mark3 Canx Psmc2 Fgf20 Psmd2 Dab2ip Prkacb Nos3 Tek Psmb9 Psmb8 Araf Hras Grin1 Ppp2r5e Hk3 Mapkap1 Pygl Dlg4 Ppp2r5c Rps6kb2 Ppp2r5d Ppp2r5a Psmc1 Psmc4 Psmc3 Gaa Pik3cb Foxo3 Pik3cd Foxo1 Pygb Itgb3 Fyn Hck Creb1 Myo1c Fcgr4 Phb Myh2 Grin2c Ppapdc1a Stat1 Ppapdc1b Rasgrp4 Fgr Rasgrp3 Myo10 Stat6 Pebp1 Camk4 Alox15 Ppp2r5b Fcgr3 Rasgrp1 Fcgr1 Ier3 Tln1 Pik3ca Cdkn1b Fga Fgb Grin2d Abl1 Grin2b Prkcsh Nr4a1 Vav3 Prr5 Hgf Gfra2 Gfra3 Pip5k1a Gfra4 Ereg Jak2 Trpm2 Pea15a Itga2b Rap1a Jak3 Wdr83 Btk Camk2d Rap1b Camk2a Fgfr4 Camk2b Psma5 Rasal3 Ip6k2 Rasal2 Psma4 Psma3 Psma6 Akt1s1 Vcl Baiap2 Camk2g Psma2 Psma1 Gfra1 Brk1 Pip5k1b Cd19 Evl Pip5k1c Psmd9 Dusp7 Iqgap1 Manba Man2b1 Actr2 Fgf16 Dusp6 Actr3 Dusp9 Fgf15 Dusp8 Kif5a Kif5b Klb Fgf18 Ncstn Them4 Sqstm1 Psmd1 Met Nckipsd Fn1 Rasal1 Arhgap9 Dusp1 Psmd3 Psmd4 Pdpk1 Psmd6 Psmd5 Dusp2 Pik3r3 Arpc3 Psmd7 Crk Pik3r1 Dusp5 Arpc2 Psmd8 Fgf10 Pik3r2 Rhou Dusp4 Ube2b Amica1 Chit1 Il31ra Il22ra1 Gm2a Slamf6 Vcp Slamf7 Ube2a Lmo7 Rchy1 Akap9 Lrrc41 Rlim Ppp2r1a Isg15 Slco4c1 Hace1 Calm4 Gbp9 Gbp5 Ube2l6 Trim25 Gbp7 Btrc Aldh3b1 Mapk9 Scamp1 Nfkb2 Krt1 Nfkb1 Tax1bp1 Ecsit Ifitm2 Fbxw11 Ifitm3 Saa3 S100a11 Mapkapk3 Arih2 Tnip2 Il22ra2 Myd88 Lrg1 Ano6 Nod2 Osbpl1a Nod1 Lamp1 Dhx9 S100b Cd200 Mapk10 Hif1a Fuca2 Tlr5 Cd207 Map3k7 Rnase2a Peli1 Znrf1 Irak2 Dtx3l Irak1 Plekho2 App Chil1 Tab1 Twist1 Tab2 Nlrx1 Tab3 Lifr Map3k1 Cd226 Ripk2 Arih1 Map2k7 Anxa2 Ager Arel1 Map2k3 Hgsnat Map2k4 Dhx58 Map3k8 Tspan14 Bst2 Rela Rnf217 Uba7 Il4 Rnf213 Il6 Nfkbia Csf3 Sell Csf2 Ilf2 Peli3 Rnf220 Ccl12 Nfkbib Tnfrsf1a 2310033P09Rik Irak4 Csf1 Csf3r Fcer2a Peli2 Ctla4 Vapa Grn Lrmp Mefv Tnfrsf1b Csf1r Lonrf1 Lif Ppl Cd86 Rnf216 Ccl5 Mrc2 Edar Ccl4 Mrc1 Lta Tnf Glipr1 Ltb 2010002M12Rik Jak1 Uba3 Tnfrsf25 Osm Fpr1 Timp1 Rnf144b Tnfsf14 Atg7 Il12b Tnfsf15 Ltbr Psen1 Ccr1 Atg5 Brwd1 Il12a Tnfsf12 Il10 Commd9 Tnfsf13 Ccl3 Trim26 Tnfsf18 Map3k14 Il13 Sh2d1a Cd80 Cd70 Trim41 Il1rn Il27ra Edaradd Tnfrsf8 Ptafr Serpinb3d Tyk2 Trim31 Relb Stat3 Casp3 Hectd3 Il10ra Cul2 Hectd1 Icam1 Hectd2 Cxcl3 Ube2o Cxcl1 Ube2f Ptgs2 Il1r2 Pstpip1 Atp6v0d2 Il1f10 Ccl22 Atp6v0d1 Tnfrsf11a Il1r1 Npepps Atp6v0b Tnfrsf11b Ube3a Ccl20 Ccr2 Ube3c Ube2m Atp6v1c2 Ccr5 Ube3b Atp6v1c1 Eda Tnfsf8 Il1b Plac8 Tnfsf4 Pkm Cxcl10 Atp6v0e Il1a Cmtm6 Tnfsf11 Il18 Prlr Cd40lg Il18rap Atp6v1g3 Tbc1d10c Atp6v1e2 Rnaset2a Atp6v1e1 Plau Atp6v0e2 Hcst Atp6v1a Prcp Atp6v1b1 H2-DMa Tcirg1 Map3k3 Il17f Atp6v1b2 Vat1 Il17a Atp6v1g1 Il17c Atp6v1g2 Il10rb Atp6v0a1 Lrr1 Atp6v0a2 Elane Golga7 Atp6v1h Lair1 Adam8 Atp6v0a4 Ubox5 Tnfrsf12a Il17rb Tnfrsf4 Il17ra Mmp25 Atp6v1d Cd27 Il17re Atp6v1f Eda2r Hebp2 Tnfrsf17 9030624J02Rik Tnfrsf14 Hp Tnfsf13b Vhl Tnfrsf18 Il17rc Kpna3 Tnfrsf13c Kpna4 Tnfrsf13b Erp44 Tnfrsf9 Kpna7 Stk10 Isg20 Prg2 Prg3 Ghdc Tmbim1 Mid1 Sike1 Vprbp Oscar Ppm1b Ypel5 Crtam Gca Qpct Nfam1 Gan Nit2 Galns Ctf1 Alox5 Hexb Ube2v2 Osmr Kcnab2 Nhlrc3 Casp4 Kctd7 Kctd6 Oasl1 Tmem30a Serpinb6a Ptprn2 Fgl2 Ifi35 Ifi30 Rnf4 Ifi27 Commd3 Mill2 Blmh Dnase1l1 Slpi Ccnf Ormdl3 Trim69 Btn1a1 Trim68 Lrrc7 Stom Det1 Trim71 Ctse Ctsf Ctso Frk Trim63 Serpinb1a Stx3 Trim62 Serpinb10 Serpinb12 Trim46 Trim45 Trim39 Trim50 Trim36 Trim35 Trim38 Plaur Trim37 Ptpn1 Batf Fbxw8 Cd300lf Srms Ifnlr1 Siglec1 Crp Cd300lg C1rb Flg2 Cstb Mbl2 Mex3c Cd53 Il1f9 Il1f6 Siglecg Il1f8 1600012H06Rik Siglece Trim14 Tmc6 Zbtb16 Ist1 Samhd1 Cntfr Pim1 Fscn1 Trim17 Klhl20 Klhl22 Klhl21 Cxadr Trim10 Trim11 Klhl25 Ppia Il6ra Herc2 Klhl13 Ebi3 Klhl11 Armc8 Usp18 Ifnar1 Lrsam1 Stat2 Vcam1 Iltifb AF251705 Btn2a2 Spsb1 Txnip Il6st Crlf1 Spsb4 Mkrn1 Herc1 Gla Herc3 Txk Herc4 Cd1d2 Spsb2 Icosl Anapc13 C1s2 Eif4g2 C1qc Degs1 C1qb Eif4e3 C1qa Eif4g3 Ghr Tec Herc6 Grap2 Fcnb Klhl41 Itk Klhl42 Lcp2 Naprt Pdzd11 Cyb5r3 Ins2 Trappc1 Bst1 Sec24a Sec24b Sptan1 Sec13 Sec24d Sec24c Cd59b Lgmn Sec31a Ttr Socs2 Cracr2a Ufl1 Socs5 Ube4a Il12rb1 Rnf126 Lilra5 Il12rb2 Prss2 Mpo Rnf115 Ptprb Spta1 Cish Sptbn4 Dctn5 Ticam2 Dctn6 Ripk3 Birc3 Ctsz Dctn1 Birc2 Serpina1d Ticam1 Traf6 Ikbkb Dctn4 Ube2v1 Tlr4 Serpina1a Ube2n Tlr3 Dync1li2 Ly96 Cd14 Dync1li1 Ikbkg Cab39 Eif4e Eif4g1 Ctsc Vnn1 Fuca1 Irf8 Irf6 Il4ra Sar1b Irf4 Aim2 Kbtbd8 Mgst1 Pa2g4 Ifit2 Gbp2 Copb1 Gbp3 Rnf7 Cd300a Mif Rnf6 Sec23a Klrg1 Unc13d Btnl9 Il18r1 Btnl2 Dok3 Icam4 Icam5 Dynll2 Gusb Aoc1 Hpse Arf1 Dzip3 Lgals3 Ube2q1 Cd160 Mgrn1 Dync1i1 Creg1 Sptbn2 Irf9 Irf5 Sptbn1 Adgre5 Il18bp Lag3 Padi2 Prdx4 Rnf130 Tollip Rnf138 Ube2e2 Mvp Rsad2 Lbp Fcer1a Rnf114 Mettl7a1 Adgrg3 Bin2 Faf2 Ifnl3 B4galt1 Clec12a Lnx1 Pias1 Kcmf1 Atp8a1 Rnf19a Rnf19b H2-DMb2 Pgrmc1 Clec4d Crisp1 Rnf182 Sec22b Prdx6 Muc1 Sptb Il11ra2 Muc4 Klrb1 Cd209a Klrc1 Clec4e Fbxo30 Icam2 Bri3 Clec10a Muc15 Fbxo32 Clec4a2 Fbxo31 Fcer1g Cotl1 Clec4n Ddx3x Muc20 Il23r Clec4b2 Rnasel Il23a Btbd6 Ifngr2 Btbd1 Ifng Il9 Fbxo27 Muc13 Erap1 Fbxo22 Fbxo21 Clcf1 Uba5 Rilp Cand1 Socs3 Il20rb Ifngr1 Il20ra Rag2 Rag1 Fbxo10 Mcemp1 Ube2cbp Dsc1 Oas1g Gm13305 Fbxo17 Tarm1 Eif4a1 Asb5 Eif4a2 Asb4 Rnf14 Asb3 Asb2 Asb1 Gsdmd Asb9 Cystm1 Arl8a Oas2 Oas3 Txlna Olr1 Asb7 Asb6 Stbd1 Fbxo40 Wsb1 Cnn2 Lat2 Rnf25 Il7 Enpp4 Ube2j1 Asb8 Atp11a Ube2j2 Ccl11 Atp11b Fbxo44 Fbxo41 Mib2 Ap2m1 Hspa8 Sdcbp Ap2a1 Ap2a2 Sh3gl2 Itgav Dnm2 Rps6ka5 Ap2s1 Dnm1 Rps6ka3 Rps6ka2 Rps6ka1 Vav2 Clta Ap2b1 Csnk2b Kif4 Cltc Dnm3 Nfasc Capn1 P2rx1 P2rx7 Kpnb1 Kpna1 Ap1s2 Ap1b1 Ap1s1 Ap1g1 H2-Q10 Ap1s3 B2m Ap1m2 Ap1m1 Trim21 Cda Mb21d1 Trim32 Zbp1 Trim56 A1bg Serpina3n Ctnnb1 Cdc23 Ube2d1 Cdc27 Cdc16 Cdc20 Ube2c Ube2e1 Anapc7 Anapc4 Anapc5 Anapc1 Anapc2 Maoa Anapc11 Anapc10 Fzr1 Fabp5 Psap Defb47 Atox1 Cfb Ahsg Lcn2 Camp Ywhaz Cfd Cap1 Bpifb2 C3 Bpifb1 Bpifb6 Gzmm Tnfaip3 Lamp2 Leap2 Defb25 Aprt Rnase2b Atp7a Chga Clu Itln1 Defb18 Cyld Ampd3 Gm15386 Pglyrp3 Pecam1 Defb36 Pglyrp4 Pglyrp2 Orm3 Eppin Impdh1 Art1 Defb29 Pglyrp1 Qsox1 Lama5 Rnase6 Bpifa1 Tgfb1 Cd63 Defb15 Reg3g Defb19 Itgax Defb14 Defb23 Bpifa2 Defb12 Reg3b Itgb5 Vtn Dnajc5 Pnp Cat Xdh Sigirr Irak3 Hsp90b1 Fth1 Cdc34 Ftl1 Ppp3cb Colec11 Rac1 Mapk8 Card9 Pak1 Pycard Ppp3ca Clec7a Nfatc2 Ppp3r1 Nfatc1 Nfatc3 Wasl Col1a2 Apob Ptk2b H2-M3 H2-M5 Vamp8 Sec61a2 Vamp3 H2-Q1 Stx4a Calr Tapbp Tlr2 Tlr6 Sec61g Sec61a1 Sec61b Pdia3 Dsg1a Dsp Pkp1 Cd36 Snap23 Tap1 Tap2 Tlr1 Tirap Tkfc Ms4a3 F13a1 Adcy7 Ptges2 Adcy6 Mcl1 Adcy5 Pros1 Lta4h Adcy4 Il13ra2 Adcy3 Il13ra1 Adcy2 Prkar2a Zeb1 Il27 Adcy1 Frs2 Cd74 Snap29 Prtn3 Epx Nras Frs3 Pigr Rasgrf1 Flt3 Cd177 Hecw2 Adcy9 Traf7 Psmf1 Cd81 Adcy8 Trim12c Raf1 Acly Psme4 Il5ra Cd93 Cd8a Fgf1 Bad Tmem63a Fcgr2b Il17rd Atad3a Fgf2 Cnksr1 Cd68 Tlr8 Cnksr2 Ms4a2 Tlr7 Traip Erbb2 Pdap1 Fgf9 Skp2 Ptk2 Flnb Treml4 Fgf7 Ncr1 Psme3 Treml2 Fgf6 Treml1 Fgf4 Ccnd1 Cd96 Fgf3 Tpp2 Retn Cant1 Acpp Huwe1 Kbtbd13 Ciita Aga Sh3rf1 Btla Abca13 Tnfaip6 Dhx36 Sugt1 Flt3l Dbnl Ltn1 Taf6l Asb18 Asb11 Asb16 Asb17 Asb14 Myo5a Ppp5c Prkar1a Rab27a Sh2d1b1 Prkar1b Asb12 Asb13 Ranbp9 Rap2c Atg12 Syngr1 Rap2b Egr1 Asb15 Ifit3b Cd200r1 Cpped1 Ppp2cb Shc1 Fbxl16 Lamtor2 Fbxl19 Chuk Fbxl14 Nrg2 Fbxl13 Ppp2ca Shc3 Fbxl15 Fbxl12 Nrg1 Akt2 Fbxl8 Akt3 Ndn Shc2 Itga4 Fbxl4 Psma7 Cntf Artn Nrtn Ptx3 Plcg1 Olfm4 Asah1 Brap Il7r Fbxo7 Psmb5 Fbxo9 Psmb4 Mospd2 Ubc Itgb7 Nrg3 Klhl2 Psmb7 Itgal Nrg4 Klhl9 Psmb6 H2-Oa Psmb2 H2-Ob Psmb3 Il9r Psmb1 Nck1 Fbxo2 Mapk3 Lnpep Akt1 Trim6 Mapk1 Trim8 Trim9 Ksr1 Ptpra Ostf1 Cct2 Dusp16 Trim3 Dusp10 Trim2 Map3k11 Il1rl1 Il1rl2 Pip4k2b Pip4k2a Pja2 Trp53 Pja1 Rbck1 Pip4k2c Paqr3 Actr10 Pik3ap1 Nbeal2 Il15 Pde1c Il11 Pde1b Ubr2 Psme2 Ubr1 Pde1a Trip12 Psme1 Ubr4 Ncam1 Sos1 Il16 Il19 Rictor Ubac1 Braf Actr1b Psmb10 Stk11ip Apbb1ip Slc15a4 Il34 Ahcyl1 Crispld2 Fbxl21 Dpp7 Il15ra Rapgef1 Fbxl20 Psmb11 Il20 Csf2rb2 Eif2ak2 Rapgef2 Csf2ra Il25 Il24 Mov10 Dock1 Cct8 Rhoa Elmo1 Elmo2 Mapkapk2 Casp8 Fadd Fasl Ripk1 Kif3c Kif3b Kif3a Yes1 Capza1 Lyn Capza2 Cbl Socs1 Gata3 Traf2 Ifnb1 Kif26a Dock2 Kif20a Kifap3 Kif22 Hbb-bt Kif23 Rbsn Npc2 Irf7 Irf1 Itgb1 Kif15 Hbb-bs Irf2 Irf3 Kif11 Ifna16 Polr2f Polr2e Polr2h Polr2k Crcp Polr3a Polr3gl Polr3k Mylip Polr3h Polr3f Polr3g Polr1d Polr1c Polr3d Polr3e Polr3b Polr3c Jup Cdh1 Sirpa Tyrobp Sirpb1b Fyb Pvrl2 Vasp Mapk11 Mapk13 Mapk12 Mapk14 Cd47 Ube2r2 Ube2q2 Mme Mavs Magt1 Arg1 Arsb Arsa Rnf135 Ube2e3 Ctsh Rnf123 Ctsa Slc44a2 Otud5 Acaa1a Rapgef4 Rapgef3 Skp1a Ddost Cul1 Vrk3 Elk1 Mef2c Mef2a Dusp3 Trem1 Siglec15 Mapk7 Cd300e Klrd1 Klrk1 Clec5a Srp14 C5ar1 Rhog Rock1 Cd300lb Cd8b1 Cul5 Rnf41 Ccr6 Mt2 Pcbp2 Txndc5 Gns Siah1a Rab5c Rab5b Atp6ap2 Pou2f1 Fbxw10 Neu1 Siah2 Il33 Rab3d Rab4b Rasgrp2 Rab37 Ltf Prl Keap1 Pomc Fpr2 Cfp C3ar1 Rab7 Vim Gsn Uba6 Cd79b Malt1 Card11 Cd79a Fbxw2 Fbxw5 Fbxw4 Fbxw9 Fbxw7 Stim1 Cd22 Trpc1 Orai1 Orai2 Anpep Dapp1 Cst3 Plcg2 Blk Bcl10 Mlec S1pr1 Blnk Cblb Syk Sh3kbp1 Rel Nfkbie Ifih1 Oprd1 Ube2g2 Ube2g1 Ube2l3 Uba1 Nlrp3 Ddx58 Gpr84 C2 C8b C8a C8g Nup85 Cd46 Nup160 Colec10 C5ar2 Rap1gap2 Rap1gap Panx1 Sipa1 Ptprj Cd101 Zap70 Ptpn22 Pla2g6 Lat Hc Dsn1 Nup107 Cenpe Kif2c Cxcr1 Birc5 Kif2b Kif18a Nup37 Nup43 Nup133 Anxa1 Kif2a Cxcr2 Ranbp2 Oprm1 Ndufc2 Pdxk Slc27a2 Hvcn1 Nlrp1a Ppbp Pld3 Smarca4 Dgat1 Prkcq Inppl1 Lpcat1 Ptprc Limk1 Bcl2 Bcl2l1 Trem2 Pak3 Pak2 Hsp90ab1 Pld2 Pld1 Myh9 Pld4 Cpne3 Cpne1 Mgam Rab14 Chrnb4 Inpp5d Eif4a3 C6 Cfi C9 C7 Cfh Agpat2 CALCITONIN-LIKE LIGAND RECEPTORS%REACTOME%R-HSA-419812.1 Calcitonin-like ligand receptors Iapp Calcrl Adm Calca Ramp2 Ramp3 Adm2 Ramp1 Calcr REV-MEDIATED NUCLEAR EXPORT OF HIV RNA%REACTOME%R-HSA-165054.2 Rev-mediated nuclear export of HIV RNA Nup85 Rcc1 Nup160 Nup37 Nup50 Tpr Nup43 Nup133 Xpo1 Ndc1 Nup214 Aaas Nup210 Nup188 Nup54 Nup35 Nupl2 Nup62 Ranbp1 Nup205 Nup155 Nup88 Pom121 Rae1 Nup93 Nup153 Ranbp2 Nup107 Ran ALKBH3 MEDIATED REVERSAL OF ALKYLATION DAMAGE%REACTOME DATABASE ID RELEASE 59%112126 ALKBH3 mediated reversal of alkylation damage Alkbh3 Ascc3 Ascc2 Ascc1 TERMINAL PATHWAY OF COMPLEMENT%REACTOME DATABASE ID RELEASE 59%166665 Terminal pathway of complement C6 C8b C9 C8a C8g C7 Clu Hc SYNTHESIS OF DOLICHYL-PHOSPHATE%REACTOME DATABASE ID RELEASE 59%446199 Synthesis of Dolichyl-phosphate Dolk Dhdds Nus1 Mvd Srd5a3 Dolpp1 MITOCHONDRIAL TRNA AMINOACYLATION%REACTOME%R-HSA-379726.1 Mitochondrial tRNA aminoacylation Lars2 Yars2 Hars2 Cars2 Qars Pars2 Kars Ears2 Vars2 Fars2 Tars2 Dars2 Nars2 Wars2 Aars2 Mars2 Iars2 Ppa2 Rars2 Sars2 Gars SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME DATABASE ID RELEASE 59%2660825 Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Adam10 Notch1 Adam17 Jag2 Dll1 Dll4 Jag1 OPSINS%REACTOME%R-HSA-419771.1 Opsins Rrh Opn1sw Opn5 Rho Opn1mw Rgr Opn3 Opn4 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS%REACTOME DATABASE ID RELEASE 59%77588 SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs Lsm11 Lsm10 Zfp473 Ncbp1 Snrpb Ncbp2 Snrpd3 Slbp AMINE OXIDASE REACTIONS%REACTOME DATABASE ID RELEASE 59%140179 Amine Oxidase reactions Maob Paox Maoa HDR THROUGH MMEJ (ALT-NHEJ)%REACTOME DATABASE ID RELEASE 59%5685939 HDR through MMEJ (alt-NHEJ) Parp1 Mre11a Nbn Lig3 Parp2 Rad50 Rbbp8 Xrcc1 Fen1 Polq ABC TRANSPORTERS IN LIPID HOMEOSTASIS%REACTOME%R-HSA-1369062.2 ABC transporters in lipid homeostasis Abca7 Abcd1 Abca12 Abca3 Abca9 Abcg4 Pex19 Abcg1 Abcg5 Abcg8 Abcd3 Abcd2 Pex3 Abca5 Apoa1 Abca6 Abca2 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 59%210500 Glutamate Neurotransmitter Release Cycle Slc1a3 Slc1a2 Slc1a7 Slc1a6 Slc38a2 Slc1a1 Gls Snap25 Arl6ip5 Ppfia2 Ppfia1 Ppfia4 Unc13b Rab3a Syt1 Vamp2 Gls2 Cplx1 Stx1a FGFR3C LIGAND BINDING AND ACTIVATION%REACTOME%R-HSA-190372.3 FGFR3c ligand binding and activation Fgf1 Fgf23 Fgf16 Fgf2 Fgf20 Fgf18 Fgf9 Galnt3 Fgf4 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE%REACTOME DATABASE ID RELEASE 59%176408 Regulation of APC C activators between G1 S and early anaphase Psmc6 Psmc5 Psmc2 Psmd2 Psmb9 Psmf1 Psmb8 Btrc Psme4 Cdk2 Cdk1 Skp1a Psmc1 Ccna1 Psmc4 Psmc3 Cul1 Ccna2 Psme3 Anapc15 Anapc11 Anapc10 Fzr1 Fbxo5 Bub1b Psmd12 Plk1 Psma7 Psmd11 Psmd14 Psma5 Psmb5 Psmb4 Ubc Psmd13 Bub3 Psmd10 Psma4 Psmb7 Psma3 Psma6 Psmb6 Psmb2 Mad2l1 Psmb3 Psmb1 Psma2 Psma1 Cdc23 Psmd9 Ube2d1 Cdc27 Cdc16 Cdc20 Ube2c Anapc16 Ube2e1 Anapc7 Psmd1 Shfm1 Psme2 Anapc4 Anapc5 Anapc1 Psme1 Anapc2 Psmd3 Psmd4 Psmb10 Psmd6 Psmd5 Psmd7 Psmb11 Psmd8 TELOMERE C-STRAND SYNTHESIS INITIATION%REACTOME%R-HSA-174430.1 Telomere C-strand synthesis initiation Prim1 Pole2 Pole Pola1 Pola2 Pole4 Prim2 Pole3 FGFR1 LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 59%190242 FGFR1 ligand binding and activation Fgf1 Fgf23 Fgf22 Fgf2 Fgf20 Fgf9 Fgf10 Fgf6 Fgf4 Fgf3 SIGNALING BY NOTCH3%REACTOME DATABASE ID RELEASE 59%1980148 Signaling by NOTCH3 Adam10 Psen2 Ncstn Jag2 Dll1 Notch3 Aph1b Dll4 Jag1 PRESYNAPTIC PHASE OF HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME DATABASE ID RELEASE 59%5693616 Presynaptic phase of homologous DNA pairing and strand exchange Chek1 Rbbp8 Topbp1 Trex1 Rfc5 Rad9a Blm Rfc3 Rad1 Rad9b Hus1 Rfc2 Rad50 Rad51b Rad51c Rfc4 Exo1 Brip1 Rad51 Nbn Atrip Dna2 Kat5 Wrn Bard1 Brca1 Rpa2 Mre11a Rpa1 Atm Rad51d Xrcc2 Rpa3 Top3a Rad17 Brca2 MITOCHONDRIAL TRANSLATION%REACTOME%R-HSA-5368287.1 Mitochondrial translation Mrps14 Mrps11 Mrps16 Mrpl41 Mrps9 Mrps15 Mrpl28 Mrps17 Mrpl35 Mtif3 Dap3 Gadd45gip1 Mrps10 Eral1 Mrps12 Mrpl40 Mrpl38 Mrps5 Mrpl39 Mrps2 Mrpl32 Mrpl33 Mtif2 Mrpl34 Mrpl36 Mrps6 Mrpl37 Mrps7 Mrps34 Mrpl20 Mrps31 Mrps30 Mrpl1 Mrpl16 Mrpl2 Mrpl17 Mrpl14 Mrpl3 Mrpl4 Mrpl12 Mrpl13 Mrpl10 Mrpl11 Mrpl9 Mrpl55 Mrpl57 Mrpl19 Mrpl18 Chchd1 Mrpl54 Mrpl30 Ptcd3 Mtrf1l Mtfmt Mrps18a Mrpl22 Mrpl21 Mrps18b Mrps18c Mrpl24 Mrpl51 Mrps23 Mrps22 Mrpl50 Mrps25 Mrpl53 Mrps24 Mrpl52 Mrps28 Aurkaip1 Mrps26 Mrps27 Tsfm Gfm2 Mrps21 Mrrf Mrpl47 Mrpl48 Gfm1 Ict1 Mrpl46 Mrpl43 Mrpl44 Mrpl49 Tufm Mrps33 Mrps35 Mrpl45 INSULIN RECEPTOR RECYCLING%REACTOME DATABASE ID RELEASE 59%77387 Insulin receptor recycling Atp6v0d2 Atp6v0d1 Atp6v0b Atp6v1c2 Atp6v1c1 Atp6v0e Atp6ap1 Atp6v1g3 Atp6v1e2 Atp6v1e1 Ins2 Atp6v0e2 Atp6v1a Atp6v1b1 Tcirg1 Insr Atp6v1b2 Atp6v1g1 Atp6v1g2 Atp6v0a1 Atp6v0a2 Atp6v1h Atp6v0a4 Atp6v1d Atp6v1f INTERLEUKIN-6 FAMILY SIGNALING%REACTOME%R-HSA-6783589.2 Interleukin-6 family signaling Jak1 Osm Jak2 Il27 Il12a Cntf Il27ra Ctf1 Tyk2 Clcf1 Stat3 Osmr Cbl Socs3 Cntfr Il12rb2 Gm13305 Il6ra Ebi3 Lifr Il11 Il6st Crlf1 Il6 Ptpn11 Il11ra2 Lif CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS%REACTOME%R-HSA-442742.1 CREB phosphorylation through the activation of Ras Actn2 Akap9 Rasgrf1 Camk2d Camk2a Raf1 Camk2b Hras Grin1 Dlg4 Nefl Camk2g Grin2a Mapk1 Rps6ka6 Creb1 Rps6ka3 Rps6ka2 Grin2c Rps6ka1 Rras Braf Pdpk1 Grin2d Grin2b RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS%REACTOME DATABASE ID RELEASE 59%168928 RIG-I MDA5 mediated induction of IFN-alpha beta pathways Irf7 Irf1 Sike1 Tbk1 Isg15 Irf2 Ube2l6 Trim25 Irf3 Ikbke Mavs Nfkb2 Tank Tax1bp1 Traf3 Nfkb1 Saa3 Pin1 Myd88 Dhx9 S100b Ifna16 App Nlrx1 Map3k1 Ager Dhx36 Dhx58 Rela Uba7 Crebbp Nfkbia Nfkbib Ep300 Atg12 Rnf216 Casp8 Fadd Rnf135 Chuk Ripk1 Atg5 Tnfaip3 Ube2d3 Ubc Ifih1 Itch Cyld Traf2 Ifnb1 Ube2d1 Traf6 Ikbkb Ube2k Ikbkg Tkfc Pcbp2 Ddx58 Otud5 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 59%211945 Phase 1 - Functionalization of compounds Cyp21a1 Nqo2 Cyp26c1 Cyp7a1 Cyp7b1 Ephx1 Aldh3a1 Nr1h4 Cyp3a16 Cyp3a13 Cyp2r1 Cyp2a5 Marc1 Marc2 Tbxas1 Aip Cyp4a32 Cyp11b1 Cyp4f39 Cyp11b2 Cyp51 Cyp2s1 Ahr Cyb5r3 Paox Cyp2j6 Cyp4a12b Maob Aldh1b1 Cyp1a2 Cyp27b1 Cyp26b1 Ptgis Ptgs1 Cyb5b Cyp1a1 Cyp2d22 Cyp2e1 Pomc Adh5 Arnt2 Adh7 Cyp17a1 Cyp24a1 Cyp2w1 Cyp2f2 Cyp2c65 Rxra Cyp26a1 Cyp2b10 Fmo1 Adh1 Fmo2 Adh4 Cyp1b1 Fmo3 Aldh2 Hsp90ab1 Ahrr Cyp4f40 Cyp2c50 Cyp2c55 Bphl Maoa Ces1d Cyp2u1 Aadac Cyp3a57 Cyp4f18 Cmbl Cyp4f17 Cyp4f15 Arnt Acss1 Cyp19a1 Cyp4b1 Cbr3 Ces2h Aoc1 Aoc2 Aoc3 Por Acss2 Cyp4f14 Fdx1 Fdx1l Ces3b Cyp11a1 Fdxr Cyp46a1 Cyp27a1 Cyp39a1 Aldh1a1 Cyp4v3 Cyp8b1 Ncoa1 Ncoa2 VRNA SYNTHESIS%REACTOME%R-HSA-192814.2 vRNA Synthesis CERAMIDE SIGNALLING%REACTOME%R-HSA-193681.2 Ceramide signalling Ngf Smpd2 Ngfr SUMO IS TRANSFERRED FROM E1 TO E2 (UBE2I, UBC9)%REACTOME DATABASE ID RELEASE 59%3065678 SUMO is transferred from E1 to E2 (UBE2I, UBC9) Sumo3 Sae1 Uba2 Ube2i CYTOSOLIC TRNA AMINOACYLATION%REACTOME%R-HSA-379716.1 Cytosolic tRNA aminoacylation Eprs Tars Qars Kars Aars Nars Hars Wars Ppa1 Cars Dars Farsa Yars Rars Eef1e1 Lars Aimp1 Farsb Iars Sars Vars Gars Mars Aimp2 SIGNALING BY BRAF AND RAF FUSIONS%REACTOME%R-HSA-6802952.1 Signaling by BRAF and RAF fusions Mark3 Akap9 Agtrap Nras Qk Clcn6 Araf Hras Raf1 Fam131b Ap3b1 Arrb2 Snd1 Aggf1 Trak1 Arrb1 Kdm7a Fxr1 Csk Cnksr1 D630045J12Rik Cnksr2 Mprip Vwf Fam114a2 Papd7 Agk Itgb3 Zc3hav1 Pebp1 Tln1 Fga Fgb Lmna Papss1 Map2k1 Fgg Jak2 Atg7 Map2k2 Itga2b Rap1a Trim24 Rap1b Vcl Mapk3 Mapk1 Ksr1 Ywhab Iqgap1 Kras Fn1 Bcl2l11 Braf Apbb1ip REGULATION OF ORNITHINE DECARBOXYLASE (ODC)%REACTOME DATABASE ID RELEASE 59%350562 Regulation of ornithine decarboxylase (ODC) Psmc6 Psmc5 Psmc2 Psmd2 Psmb9 Psmb8 Psmf1 Psme4 Psmc1 Psmc4 Psmc3 Psme3 Oaz3 Oaz2 Odc1 Oaz1 Nqo1 Azin1 Psmd12 Psma7 Psmd11 Psmd14 Psma5 Psmb5 Psmb4 Psmd13 Psmd10 Psma4 Psma3 Psmb7 Psma6 Psmb6 Psmb2 Psmb3 Psma2 Psmb1 Psma1 Psmd9 Psmd1 Psme2 Shfm1 Psme1 Psmd3 Psmd4 Psmb10 Psmd6 Psmd5 Psmd7 Psmb11 Psmd8 TRANS-GOLGI NETWORK VESICLE BUDDING%REACTOME DATABASE ID RELEASE 59%199992 trans-Golgi Network Vesicle Budding Golgb1 Pik3c2a Rab5c Ap3b1 Arrb1 Arf1 Fth1 Ftl1 App Hgs Ocrl Cltb Bloc1s4 Tbc1d8b Bloc1s3 Vamp8 Bloc1s6 Hspa8 Stx4a Necap1 Acbd3 Hip1r Picalm M6pr Dtnbp1 Cpd Chmp2a Pum1 Igf2r Gak Gbf1 Sh3gl2 Dnm2 Napa Tfrc Ctsz Ap4b1 Clvs1 Ap1g2 Clta Ap1s2 Clint1 Tpd52l1 Ap1b1 Bloc1s1 Cltc Ap1s1 Sort1 Ap1g1 Snap23 Snx2 Dnajc6 Ap3s1 Sh3d19 Yipf6 Snapin Ap1s3 Ap4e1 Vamp7 Ap4s1 Vamp2 Clvs2 Snx9 Txndc5 Ap4m1 Snx5 Ap1m2 Dnase2a Ap1m1 Gns ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT)%REACTOME DATABASE ID RELEASE 59%917729 Endosomal Sorting Complex Required For Transport (ESCRT) Chmp5 Chmp7 Chmp6 Chmp3 Vps37d Vps37c Vps25 Vps37b Tonsl Vps4b Vps4a Vta1 Chmp2a Chmp4c Chmp4b Ubc Tsg101 Snf8 Vps37a Vps36 Stam Hgs Stam2 TERMINATION OF O-GLYCAN BIOSYNTHESIS%REACTOME%R-HSA-977068.1 Termination of O-glycan biosynthesis St3gal1 St3gal2 Muc15 St6galnac4 St3gal4 St6galnac3 Muc20 St6gal1 Muc1 Muc4 Muc13 St6galnac2 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME DATABASE ID RELEASE 59%186712 Regulation of beta-cell development Akt2 Akt3 Notch1 Slc2a2 Neurog3 Akt1 Foxo1 Pax4 Insm1 Hnf4g Iapp Ins2 Hnf1a Hnf1b Rfx6 Onecut3 Nkx6-1 Onecut1 Neurod1 Foxa2 Mafa Ptf1a Foxa3 Pdx1 Rbpj Nkx2-2 Fgf10 Gck Pax6 Hes1 AMPLIFICATION OF SIGNAL FROM UNATTACHED KINETOCHORES VIA A MAD2 INHIBITORY SIGNAL%REACTOME%R-HSA-141444.2 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Mad1l1 Mad2l1 METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS%REACTOME DATABASE ID RELEASE 59%2022377 Metabolism of Angiotensinogen to Angiotensins Ace2 Enpep Ctsz Gzmf Anpep Ace Ctsg Mme Cpb2 Agt Cma1 Cpa3 Ctsd Atp6ap2 Cpb1 2010111I01Rik PIWI-INTERACTING RNA (PIRNA) BIOGENESIS%REACTOME DATABASE ID RELEASE 59%5601884 PIWI-interacting RNA (piRNA) biogenesis Tdrd1 Hsp90aa1 Polr2i Polr2f Polr2j Polr2e Polr2h Tdrd12 Polr2c Polr2d Polr2b Henmt1 Piwil4 Polr2k Polr2g Asz1 Piwil1 Tdrkh Piwil2 Fkbp6 Mybl1 Tdrd9 Tdrd6 Polr2a Mael Mov10l1 Ddx4 COPI-MEDIATED ANTEROGRADE TRANSPORT%REACTOME%R-HSA-6807878.1 COPI-mediated anterograde transport Arfgap3 Arfgap1 Arfgap2 Golgb1 Copb2 Stx5a Copb1 Copz1 Ank1 Ank3 Copz2 Copg1 Gosr1 Golga2 Dynll2 Gosr2 Arf1 Kdelr1 Arf3 Arf4 Dync1i1 Sptbn2 Sptbn1 Ins2 Rab1 Copa Dynll1 Sptan1 Tmed3 Cope Dync1i2 Arcn1 Sptb Ykt6 Cd59b Cog6 Dctn2 Cog3 Cog4 Dctn3 Cog2 Cog1 Gorasp1 Nsf Dync1h1 Tmed9 Bet1l Gbf1 Napb Napg Napa Spta1 Sptbn4 Dctn5 Dctn6 Dctn1 Dctn4 Dync1li2 Folr1 Dync1li1 Rab1b Arf5 Kdelr2 Kdelr3 Uso1 Bet1 Cog7 Tmem115 Cog8 RAF MAP KINASE CASCADE%REACTOME DATABASE ID RELEASE 59%5673001 RAF MAP kinase cascade Akap9 Ppp2r1a Csf2 Jak1 Frs2 Nras Frs3 Rasgrf1 Psmf1 Raf1 Psme4 Il5ra Fgf1 Il17rd Fgf2 Csk Cnksr1 Cnksr2 Erbb2 Fgf9 Ptk2 Fgf7 Psme3 Fgf6 Fgf4 Fgf3 Ppp5c Ranbp9 Ppp2cb Shc1 Lamtor2 Nrg2 Ppp2ca Shc3 Nrg1 Shc2 Psma7 Artn Nrtn Brap Psmb5 Psmb4 Ubc Nrg3 Psmb7 Nrg4 Psmb6 Psmb2 Psmb3 Psmb1 Mapk3 Mapk1 Ksr1 Ptpra Dusp16 Dusp10 Map3k11 Paqr3 Psme2 Psme1 Ncam1 Sos1 Braf Psmb10 Apbb1ip Psmb11 Csf2rb2 Rapgef2 Csf2ra Actn2 Nf1 Pdgfrb Pdgfra Kbtbd7 Il2rg Arrb2 Egfr Arrb1 Ret Vwf Sptan1 Pspn Map2k1 Rbx1 Fgg Map2k2 Cul3 Psmd12 Pdgfb Psmd11 Rasgef1a Psmd14 Rasa3 Rasa4 Psmd13 Psmd10 Il2 Rasa2 Rasa1 Nefl Spred3 Kit Spred2 Grin2a Spred1 Spta1 Il5 Ppp2r1b Sptbn4 Ywhab Kras Gdnf Shfm1 Irs2 Syngap1 Hbegf Irs1 Il3ra Btc Il2ra Il2rb Angpt1 Psmc6 Egf Fgf23 Psmc5 Fgf22 Mark3 Psmc2 Fgf20 Psmd2 Dab2ip Tek Psmb9 Psmb8 Araf Hras Grin1 Ppp2r5e Dlg4 Ppp2r5c Ppp2r5d Ppp2r5a Psmc1 Psmc4 Psmc3 Sptbn2 Itgb3 Sptbn1 Fyn Phb Grin2c Rasgrp4 Rasgrp3 Pebp1 Ppp2r5b Rasgrp1 Tln1 Fga Fgb Grin2d Grin2b Sptb Hgf Gfra2 Gfra3 Gfra4 Ereg Jak2 Pea15a Itga2b Rap1a Jak3 Wdr83 Camk2d Rap1b Camk2a Fgfr4 Camk2b Psma5 Rasal3 Rasal2 Psma4 Psma3 Psma6 Vcl Camk2g Psma2 Psma1 Gfra1 Psmd9 Dusp7 Iqgap1 Fgf16 Dusp6 Dusp9 Fgf15 Dusp8 Klb Fgf18 Psmd1 Met Fn1 Rasal1 Dusp1 Psmd3 Psmd4 Psmd6 Psmd5 Dusp2 Psmd7 Dusp5 Psmd8 Fgf10 Dusp4 DISEASES ASSOCIATED WITH O-GLYCOSYLATION OF PROTEINS%REACTOME%R-HSA-3906995.2 Diseases associated with O-glycosylation of proteins Adamts12 Thsd4 Muc15 Adamts19 Thsd1 Muc20 Adamts10 Sspo Muc13 Notch1 Adamts20 Cfp Adamtsl3 Adamtsl4 Adamts4 Adamtsl1 Notch4 Adamts13 Adamts1 Adamtsl2 Adamts14 Sbspon Adamts15 Sema5a Spon2 Dag1 Thsd7a Adamts8 Adamts5 Notch3 Adamtsl5 Spon1 Notch2 Adamts3 Adamts18 Adamts6 Adamts16 Adamts7 Adamts2 Thbs1 Thsd7b Muc1 Muc4 Thbs2 Sema5b SIGNALING BY FGFR2 IIIA TM%REACTOME DATABASE ID RELEASE 59%8851708 Signaling by FGFR2 IIIa TM Polr2f Polr2i Polr2e Polr2j Polr2h Polr2c Polr2d Polr2b Polr2g Polr2k Fgf1 Fgf2 Polr2a Gtf2f1 Ncbp1 Fgfr2 Ncbp2 Gtf2f2 G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA%REACTOME DATABASE ID RELEASE 59%392451 G beta:gamma signalling through PI3Kgamma Gngt1 Shc1 Gng7 Gng4 Jak1 Jak2 Gngt2 Akt2 Akt3 Jak3 Gng10 Il2rg Gab2 Il5ra Il2 Pik3r6 Rhoa Pik3r5 Pik3cb Pik3cd Akt1 Il5 Pik3ca Gng11 Gng13 Gng12 Gnb2 Csf2 Gnb1 Pdpk1 Gnb3 Gnb5 Pik3cg Pik3r3 Gnb4 Il3ra Pik3r1 Il2ra Gng8 Il2rb Csf2rb2 Gng3 Gng2 Pik3r2 Csf2ra REGULATION OF SIGNALING BY CBL%REACTOME%R-HSA-912631.1 Regulation of signaling by CBL Hck Fyn Crkl Blnk Syk Pik3ca Yes1 Vav1 Lyn Cbl Pik3r3 Crk Rapgef1 Pik3r1 Pik3cb Pik3cd Pik3r2 TAT-MEDIATED ELONGATION OF THE HIV-1 TRANSCRIPT%REACTOME DATABASE ID RELEASE 59%167246 Tat-mediated elongation of the HIV-1 transcript Gtf2h5 Gtf2h4 Cdk9 Gtf2h3 Ercc3 Ercc2 Polr2i Polr2f Polr2j Polr2e Nelfa Polr2h Nelfb Ell Polr2c Mnat1 Polr2d Supt4a Tcea1 Polr2b Tceb1 Tceb3 Supt16 Polr2k Polr2g Ccnt1 Ctdp1 Ssrp1 Ccnh Cdk7 Polr2a Nelfe Supt5 Nelfcd Gtf2h1 Gtf2f1 Ncbp1 Ncbp2 Gtf2h2 Gtf2f2 ACTIVATION OF NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME DATABASE ID RELEASE 59%629602 Activation of Nicotinic Acetylcholine Receptors Chrnb2 Chrnb4 Chrnb3 Chrnd Chrng Chrna9 Chrne Chrna4 Chrna5 Chrna3 Chrna1 Chrna6 Chrna7 Chrna2 PI3K EVENTS IN ERBB2 SIGNALING%REACTOME DATABASE ID RELEASE 59%1963642 PI3K events in ERBB2 signaling Egf Ereg Nrg2 Nrg1 Pik3ca Egfr Gab1 Nrg3 Nrg4 Hbegf Erbb2 Btc Pik3r1 POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME DATABASE ID RELEASE 59%622327 Postsynaptic nicotinic acetylcholine receptors Chrnb2 Chrnb4 Chrnb3 Chrnd Chrng Chrna9 Chrne Chrna4 Chrna5 Chrna3 Chrna1 Chrna6 Chrna7 Chrna2 DEFECTIVE B3GALT6 CAUSES EDSP2 AND SEMDJL1%REACTOME%R-HSA-4420332.1 Defective B3GALT6 causes EDSP2 and SEMDJL1 Agrn Sdc3 Sdc4 Gpc6 Bgn Sdc2 Dcn Gpc3 Sdc1 Gpc5 Bcan Gpc2 Gpc4 Cspg4 Cspg5 Ncan Vcan Hspg2 Gpc1 DEATH RECEPTOR SIGNALLING%REACTOME%R-HSA-73887.2 Death Receptor Signalling Fas Casp8 Fadd Tnf Chuk Tradd Fasl Ripk1 Tnfrsf10b Tnfsf10 Tnfaip3 Usp21 Bag4 Xiap Tax1bp1 Ubc Otulin Otud7b Usp2 Usp4 Clip3 Cyld Traf1 Traf2 Sharpin Map3k7 Smpd3 Gnb2l1 Nsmaf Birc3 Birc2 Tab1 Tab2 Tab3 Rbck1 Ikbkb Sppl2a Sppl2b Rnf31 Ikbkg Cflar Tnfrsf1a Adam17 Smpd2 PI-3K CASCADE:FGFR2%REACTOME%R-HSA-5654695.2 PI-3K cascade:FGFR2 Fgf23 Fgf16 Fgf22 Fgf20 Frs2 Fgf18 Pik3ca Fgf1 Gab1 Fgf2 Fgf9 Pik3r1 Fgf7 Ptpn11 Fgf6 Fgf10 Fgf4 Fgf3 DOPAMINE RECEPTORS%REACTOME DATABASE ID RELEASE 59%390651 Dopamine receptors Drd4 Drd5 Drd2 Drd3 Drd1 BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME%R-HSA-70895.2 Branched-chain amino acid catabolism Mccc2 Mccc1 Acat1 Bcat2 Acad8 Bbox1 Ivd Dld Aldh6a1 Bckdk Bcat1 Hibadh Hsd17b10 Auh Shmt1 Aldh9a1 Dbt Tmlhe Ppm1k Bckdha Bckdhb Acadsb Hibch TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES%REACTOME%R-HSA-382551.1 Transmembrane transport of small molecules Magt1 Slc6a12 Slc6a7 Slc6a11 Tusc3 Slc22a2 Rhag Slc22a1 Slc44a3 Slc44a4 Slc3a2 Slc44a5 Slc35d1 Rhcg Slc6a9 Slc5a7 Slc44a1 Slc6a5 Slc44a2 Slc6a6 Slc14a2 Slc18a1 Slc6a20a Slc14a1 Slc6a18 Slc6a19 Slc6a1 Slc6a2 Slc7a5 Arhgef9 Slc6a13 Slc6a15 Slc6a14 Rhbg Gck Abcd1 Nup50 Slc34a1 Slc34a3 Slc20a1 Tpr Slc20a2 Clcn6 Slc2a6 Ndc1 Slc2a5 Nup214 Aaas Nup210 Nup188 Nup54 Nup35 Slc34a2 Slc2a12 Nupl2 Nup62 Slc2a4 Slc2a3 Nup205 Slc2a10 Nup155 Slc2a2 Nup88 Slc2a1 Pom121 Slc2a8 Slc2a7 Rae1 Nup93 Slc13a3 Emb Slc13a1 Nup153 Slc13a2 Slc13a5 Slc16a3 Slc16a1 Bsg Fxyd7 Slc13a4 Slc16a8 Slc10a6 Slc16a7 Slc47a1 Fxyd1 Fxyd4 Fxyd6 Abca4 Atp1a1 Slc8a2 Erlin2 Slc8a1 Fkbp1b Atp1b2 Atp1a2 Atp1a3 Slc8a3 Wwp1 Atp1b3 Atp1b1 Ryr3 Ryr1 Ryr2 Fgf21 Slc2a9 Atp2a1 Trdn Atp2a3 Atp2a2 Asph Atp2b3 Atp2b4 Atp2b1 Atp2b2 Sri Slc18a2 Erlec1 Scnn1b Slc39a14 Cybrd1 Scnn1a Cp Scnn1g G6pc2 Slco2a1 G6pc3 Clcn5 Slc9b1 Clcn7 Slc9b2 Slc17a5 Psmd12 Psmd11 Psmd14 Psmd13 Psmd10 Shfm1 Avp Avpr2 Slc6a3 Psmc6 Hk1 Gngt1 Gng7 Psmc5 Gng4 Hmox1 Psmc2 Slc25a10 Gngt2 Hmox2 Psmd2 Gng10 Prkacb Psmb9 Psmb8 Hk2 Prkar2b Hk3 Psmc1 Psmc4 Psmc3 Apod Rab11a Trpc1 Lcn9 Slc27a1 Slc27a6 Lcn12 Gng11 Slc27a4 Gng13 Gng12 Gnb2 Slc35b2 Gnb1 Slc26a1 Gnb3 Gnb5 Gnb4 Prkaca Gng8 Slc26a2 Gng3 Slc35b3 Gng2 Trpv1 Trpv3 Trpv2 Lcn2 Alb Trpv4 Abcc4 Trpa1 Trpm2 Slc5a2 Trpc4 Trpm1 Slc5a3 Trpm7 Slc5a1 Mcoln3 Sgk1 2010001E11Rik Mcoln2 Slc5a9 Camk2d Slc5a4a Cftr Trpc5 Trpm3 Camk2a Trpm6 Trpm5 Camk2b Trpm8 Psma5 Add1 Trpm4 Abcb6 Abcb10 Trpc4ap Atp7a Psma4 Psma3 Abcb8 Psma6 Camk2g Psma2 Psma1 Psmd9 Psmd1 Slc11a1 Psmd3 Psmd4 Psmd6 Psmd5 Psmd7 Psmd8 Trpv6 Trpv5 Slc22a6 Abcc9 Glrb Trpc6 Slc26a11 Ano8 Nup85 Ano7 Ano5 Slc1a3 Vcp Nup160 Slc33a1 Slc1a2 Ano4 Slc12a4 Slc1a7 Atp8b2 Slc1a6 Slco4c1 Slc39a1 Slc38a2 Slc12a5 Slc1a1 Mip Slc22a3 Slc22a4 Slc22a5 Slc39a5 Slc12a1 Slc39a4 Slc32a1 Slc12a2 Slc12a3 Slc39a3 Atp8b1 Slc39a2 Clca4a Atp8a2 Slc12a6 Ano6 Slc12a7 Atp8b3 Slc39a8 Slc39a6 Slc39a7 Ostm1 Slc43a1 Sgk3 Fth1 Sgk2 Slc25a22 Ftl1 Slc3a1 Slc43a2 Slc25a26 Slc28a3 Abcb1a Slc50a1 Slc28a1 Slc22a8 Slc22a7 Slc25a18 Pip G6pc Slc29a1 Dmtn Abcc10 Azgp1 Pqlc2 Slc2a13 Atp2c1 Nipal4 Nedd4l Slc28a2 Mrs2 Slc29a4 Nipal1 Slc29a2 Nipal2 Slc29a3 Mmgt1 Nup107 Tsc22d3 Nipal3 Ank Abcf1 Nipa2 Atp4a Trpc3 Atp4b Add3 Stoml3 Add2 Atp2c2 Ctns Apoa1 Nipa1 Cutc Abcg2 Trpc7 Nalcn Slc41a2 Slc41a1 Abce1 Slc1a5 Slc1a4 Slc40a1 Nup37 Nup43 Nup133 Atp6v0d2 Atp6v0d1 Atp6v0b Atp6v1c2 Atp6v1c1 Mcoln1 Steap2 Atp6v0e Atp6ap1 Atp6v1g3 Atp6v1e2 Abca3 Tfrc Atp6v1e1 Atp6v0e2 Atp6v1a Atp6v1b1 Tcirg1 Trf Atp6v1b2 Atp6v1g1 Atp6v1g2 Atp6v0a1 Atp6v0a2 Atp6v1h Atp6v0a4 Atp6v1d Atp6v1f Ranbp2 Adcy7 Slc9c1 Adcy6 Abcc6 Adcy5 Abcb4 Adcy4 Slc16a2 Adcy3 Abcb9 Adcy2 Abcb5 Prkar2a Atp7b Adcy1 Slc38a1 Slc30a1 Slco2b1 Best3 Best2 Adcy9 Slc39a10 Psmf1 Slc30a2 Adcy8 Best1 Raf1 Slc30a3 Psme4 Atp10b Rab11fip2 Atp11c Atp12a Atp13a5 Atp13a4 Atp13a2 Atp13a1 Bsnd Slc8b1 Slc38a5 Slc38a4 Psme3 Slc38a3 Slc37a4 Abcc3 Abcc2 Slc7a6 Slco4a1 Slc7a1 Slc7a3 Unc79 Slc7a9 Slc7a8 Slc7a7 Atp9a Atp9b Atp10d Stom Myo5b Clcn1 Atp10a Clcn2 Clcn3 Slc30a5 Slc22a12 Aqp9 Slc30a8 Steap3 Aqp5 Aqp4 Slc22a16 Prkar1a Slc22a17 Prkar1b Slc22a15 Slc30a6 Aqp8 Slc30a7 Slc4a7 Slc4a9 Slc22a18 Slc4a8 Asic1 Slc11a2 Asic4 Asic5 Slc4a3 Slc7a10 Heph Slc4a4 Slc4a2 Clca1 Slc4a5 Slc7a11 Aqp11 Aqp7 Aqp12 Psma7 Aqp6 Htr3a Htr3b Aqp2 Aqp3 Slc24a4 Psmb5 Slc24a3 Psmb4 Slc24a2 Ubc Slc24a1 Ttyh3 Psmb7 Slco1c1 Slc15a3 Psmb6 Slc4a10 Psmb2 Slco1a4 Psmb3 Slc5a12 Psmb1 Slc5a11 Clca2 Slco1b2 Slc45a3 Ahcyl2 Slc5a10 Slc17a1 Slc5a5 Slc17a3 Mfsd7b Slc15a2 Slc15a1 Tpcn2 Tpcn1 Ttyh2 Wnk4 Slc24a5 Slc17a6 Psme2 Wnk1 Wnk2 Psme1 Slc17a8 Wnk3 Kcnj11 Abca8b Abcc8 Glra1 Ano1 Psmb10 Slc31a1 Glra4 Slc15a4 Clcn4-2 Ano2 Ano10 Slc26a3 Slc26a4 Clcnka Psmb11 Clcnkb Slc26a9 Slc26a7 Glra3 Glra2 Os9 Rnf185 Derl2 Rnf5 Sel1l Pdzd11 Aqp1 Slc4a1 Abca7 Abca12 Abca9 Abcg4 Slc5a8 Slc5a6 Pex19 Slc46a1 Abcc1 Abcd3 Abcd2 Pex3 Slc36a1 Abca5 Slc36a2 Abca6 Abca2 Eif2s1 Eif2s2 Eif2s3x Abcg1 Abcg5 Abcg8 Atp8a1 Gabrr2 Gabrr3 Gabrb2 Gabrr1 Gabrq Rnasel Gabra2 Gabra5 Gabra1 Gabra6 Gabra3 Gabra4 Slc9a1 Slc9a6 Gabrg2 Gabrg3 Slc9a5 Slc9a4 Slc9a3 Slc9a2 Slc9a9 Slc9a8 Slc9a7 Erlin1 Slc35b4 Gckr Slc35a1 Slc35a3 Derl1 Derl3 Slc35c1 Abcc5 Slc35a2 Slc35d2 Atp11a Atp11b Gabrb3 Gabrb1 HEDGEHOG 'OFF' STATE%REACTOME DATABASE ID RELEASE 59%5610787 Hedgehog 'off' state Adcy7 Psmc6 Mks1 Adcy6 Rpgrip1l Adcy5 Adcy4 Psmc5 Adcy3 Adcy2 Prkar2a Psmc2 Adcy1 Psmd2 Prkacb Adcy9 Psmb9 Psmf1 Psmb8 Adcy8 Btrc Psme4 Prkar2b Skp1a Ofd1 Psmc1 Psmc4 Psmc3 Cul1 Psme3 Smo Ptch1 Prkar1a Prkar1b Prkaca Rbx1 Csnk1a1 Psmd12 Psma7 Psmd11 Kif3a Psmd14 Psma5 Psmb5 Psmb4 Ubc Psmd13 Itch Psmd10 Psma4 Psmb7 Psma3 Psma6 Psmb6 Psmb2 Psmb3 Psmb1 Psma2 Psma1 Gpr161 Intu Fuz Adcy10 Tulp3 Sufu Psmd9 Gli3 Ift140 Ift122 Ift52 Ift172 Ift57 Wdr19 Ttc21b Gli2 Gsk3b Dync2h1 Wdr35 Gli1 Psmd1 Shfm1 Psme2 Ift88 Psme1 Psmd3 Psmd4 Psmb10 Numb Psmd6 Psmd5 Psmd7 Psmb11 Psmd8 SIGNALING BY EGFR%REACTOME DATABASE ID RELEASE 59%177929 Signaling by EGFR Akap9 Ppp2r1a Csf2 Cd86 Spry2 Jak1 Cd80 Sh3gl2 Arhgef7 Ptprk Adam12 Eps15l1 Epn1 Lrig1 Spry1 Adcy7 Adcy6 Adcy5 Adcy4 Adcy3 Adcy2 Prkar2a Adcy1 Frs2 Nras Frs3 Rasgrf1 Adcy9 Psmf1 Adcy8 Raf1 Psme4 Il5ra Fgf1 Bad Il17rd Fgf2 Cnksr1 Csk Cnksr2 Erbb2 Fgf9 Ptk2 Fgf7 Psme3 Fgf6 Fgf4 Fgf3 Ppp5c Prkar1a Prkar1b Ranbp9 Ppp2cb Shc1 Lamtor2 Adam10 Chuk Nrg2 Ppp2ca Shc3 Nrg1 Akt2 Akt3 Shc2 Psma7 Artn Nrtn Plcg1 Brap Psmb5 Psmb4 Ubc Nrg3 Psmb7 Nrg4 Psmb6 Psmb2 Psmb3 Psmb1 Mapk3 Akt1 Mapk1 Ksr1 Ptpra Dusp16 Dusp10 Map3k11 Pip4k2b Pip4k2a Trp53 Pip4k2c Paqr3 Pik3ap1 Pde1c Pde1b Psme2 Pde1a Psme1 Ncam1 Sos1 Rictor Braf Psmb10 Apbb1ip Ahcyl1 Adam17 Psmb11 Csf2rb2 Rapgef2 Csf2ra Mov10 Casp9 Prkcd Prkce Actn2 Nf1 Prkcg Tsc2 Pdgfrb Pdgfra Mlst8 Kbtbd7 Prkca Vav1 Il2rg Arrb2 Egfr Gab1 Arrb1 Mtor Ret Phlpp1 Adrbk1 Vwf Phlpp2 Ins2 Sptan1 Sh3gl1 Stam Hgs Stam2 Eps15 Pspn Map2k1 Rbx1 Fgg Cdkn1a Map2k2 Cul3 Psmd12 Pdgfb Psmd11 Rasgef1a Psmd14 Rasa3 Rasa4 Psmd13 Cbl Psmd10 Il2 Rasa2 Rasa1 Nefl Spred3 Kit Spred2 Grin2a Spta1 Spred1 Il5 Sptbn4 Ppp2r1b Ywhab Ago2 Ago1 Ptpn12 Tnrc6c Kras Insr Gsk3a Gsk3b Tnrc6b Gdnf Shfm1 Tnrc6a Ago4 Ago3 Itpr1 Trat1 Irs2 Mdm2 Lck Syngap1 Pten Hbegf Irs1 Il3ra Btc Il2ra Il2rb Itpr3 Ptpn11 Angpt1 Itpr2 Trib3 Psmc6 Egf Fgf23 Psmc5 Pag1 Fgf22 Mark3 Psmc2 Fgf20 Psmd2 Dab2ip Prkacb Tek Psmb9 Psmb8 Araf Hras Grin1 Prkar2b Ppp2r5e Mapkap1 Dlg4 Ppp2r5c Rps6kb2 Ppp2r5d Ppp2r5a Psmc1 Psmc4 Psmc3 Pik3cb Foxo3 Sptbn2 Pik3cd Foxo1 Sptbn1 Itgb3 Fyn Creb1 Phb Grin2c Rasgrp4 Rasgrp3 Pebp1 Camk4 Ppp2r5b Rasgrp1 Sh3kbp1 Ier3 Tln1 Pik3ca Cdkn1b Fga Fgb Grin2d Prkaca Grin2b Nr4a1 Sptb Prr5 Hgf Gfra2 Gfra3 Pip5k1a Gfra4 Ereg Jak2 Pea15a Itga2b Rap1a Jak3 Wdr83 Camk2d Rap1b Camk2a Fgfr4 Camk2b Psma5 Rasal3 Pxn Rasal2 Psma4 Psma3 Psma6 Akt1s1 Vcl Camk2g Psma2 Psma1 Gfra1 Pip5k1b Cd19 Pip5k1c Psmd9 Dusp7 Iqgap1 Fgf16 Dusp6 Dusp9 Fgf15 Dusp8 Klb Fgf18 Them4 Psmd1 Met Fn1 Rasal1 Dusp1 Psmd3 Psmd4 Pdpk1 Psmd6 Psmd5 Dusp2 Pik3r3 Psmd7 Pik3r1 Dusp5 Psmd8 Fgf10 Pik3r2 Dusp4 PROPIONYL-COA CATABOLISM%REACTOME DATABASE ID RELEASE 59%71032 Propionyl-CoA catabolism Mut Pcca Mmaa Pccb Mcee INTERACTIONS OF TAT WITH HOST CELLULAR PROTEINS%REACTOME%R-HSA-176034.2 Interactions of Tat with host cellular proteins Ccnt1 Cdk9 ELASTIC FIBRE FORMATION%REACTOME%R-HSA-1566948.1 Elastic fibre formation Ltbp2 Ltbp4 Mfap1b Itga8 Itgb1 Ltbp3 Gdf5 Efemp2 Tgfb3 Ltbp1 Tgfb2 Fbn1 Efemp1 Itgav Itgb3 Loxl4 Loxl3 Tgfb1 Loxl2 Loxl1 Lox Furin Itgb6 Fbn2 Itgb5 Eln Vtn Bmp4 Bmp2 Mfap2 Mfap3 Mfap5 Bmp7 Bmp10 Mfap4 Itgb8 Fbln1 Itga5 Fbln2 Fbln5 MYD88 DEFICIENCY (TLR5)%REACTOME DATABASE ID RELEASE 59%5602680 MyD88 deficiency (TLR5) Irak4 Myd88 Tlr5 SIGNALLING TO STAT3%REACTOME DATABASE ID RELEASE 59%198745 Signalling to STAT3 Stat3 Ngf Ntrk1 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS%REACTOME DATABASE ID RELEASE 59%997272 Inhibition of voltage gated Ca2+ channels via Gbeta gamma subunits Gngt1 Gng7 Gng4 Kcnj5 Kcnj9 Kcnj10 Gngt2 Kcnj3 Gng10 Kcnj16 Kcnj15 Gabbr2 Gabbr1 Kcnj2 Gng12 Kcnj12 Gnb2 Gnb1 Kcnj4 Gnb3 Gng8 Kcnj6 Gng3 Gng2 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE%REACTOME DATABASE ID RELEASE 59%1660514 Synthesis of PIPs at the Golgi membrane Pik3c3 Pi4kb Pi4k2b Pik3c2a Pik3r4 Pik3c2g Pi4k2a Inpp5e Sacm1l Arf1 Tpte Pikfyve Pi4ka Fig4 Arf3 Ocrl Vac14 PEROXISOMAL LIPID METABOLISM%REACTOME DATABASE ID RELEASE 59%390918 Peroxisomal lipid metabolism Abcd1 Acaa1a Acox2 Hsd17b4 Acbd4 Acot8 Ehhadh Hacl1 Acbd5 Nudt7 Acox3 Slc25a17 Agps Hao2 Mlycd Acoxl Nudt19 Crot Pecr Gnpat Crat Phyh Idh1 Amacr Slc27a2 AXIN MUTANTS DESTABILIZE THE DESTRUCTION COMPLEX, ACTIVATING WNT SIGNALING%REACTOME%R-HSA-4839735.1 AXIN mutants destabilize the destruction complex, activating WNT signaling Ppp2r1b Ppp2cb Apc Axin1 Ppp2ca Amer1 Csnk1a1 Gsk3b Ppp2r1a Ppp2r5b Ppp2r5e Ppp2r5c Ppp2r5d Ppp2r5a TOLL LIKE RECEPTOR 2 (TLR2) CASCADE%REACTOME DATABASE ID RELEASE 59%181438 Toll Like Receptor 2 (TLR2) Cascade Ppp2r1a Btrc Mapk9 Nfkb2 Nfkb1 Ecsit Fbxw11 Skp1a Saa3 Ppp2r5d Mapkapk3 Tnip2 Myd88 Nod2 Cul1 Nod1 Dhx9 Vrk3 S100b Elk1 Mef2c Mapk10 Mef2a Sigirr Dusp3 Map3k7 Mapk7 Irak3 Peli1 Creb1 Mapkapk2 Irak2 Irak1 App Map2k6 Tab1 Tab2 Jun Mapk8 Tab3 Map3k1 Ripk2 Map2k7 Ager Map2k3 Map2k4 Map3k8 Rela Atf2 Nfkbia Peli3 Nfkbib Irak4 Fos Peli2 Ppp2cb Map2k1 Chuk Ppp2ca Btk Tlr2 Tlr6 Ubc Socs1 Mapk3 Rps6ka5 Mapk1 Ppp2r1b Dusp7 Rps6ka3 Dusp6 Rps6ka2 Rps6ka1 Traf6 Ikbkb Ube2v1 Tlr4 Ube2n Ly96 Cd14 Ikbkg Mapk11 Cd36 Mapk14 Tlr1 Tirap Dusp4 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL%REACTOME DATABASE ID RELEASE 59%1855204 Synthesis of IP3 and IP4 in the cytosol Plch2 Plch1 Itpkb Itpkc Plcd4 Plcd1 Plcg2 Inpp5d Plcz1 Plcd3 Plcb1 Plcb2 Plcg1 Plcb4 Plcb3 Itpk1 Inppl1 Pten Plce1 Itpka Ocrl Synj1 Pld4 Inpp5b ONCOGENIC MAPK SIGNALING%REACTOME DATABASE ID RELEASE 59%6802957 Oncogenic MAPK signaling Mark3 Nf1 Akap9 Nras Dab2ip Agtrap Qk Clcn6 Araf Raf1 Hras Fam131b Ap3b1 Arrb2 Snd1 Aggf1 Trak1 Arrb1 Kdm7a Fxr1 Csk Cnksr1 D630045J12Rik Cnksr2 Mprip Vwf Fam114a2 Papd7 Agk Itgb3 Zc3hav1 Phb Pebp1 Tln1 Fga Fgb Lmna Papss1 Map2k1 Jak2 Fgg Atg7 Map2k2 Itga2b Rap1a Trim24 Rap1b Brap Rasa3 Rasal3 Rasa4 Rasal2 Rasa2 Rasa1 Vcl Mapk3 Mapk1 Ksr1 Ywhab Iqgap1 Map3k11 Kras Fn1 Bcl2l11 Rasal1 Braf Syngap1 Apbb1ip SYNTHESIS OF PIPS IN THE NUCLEUS%REACTOME DATABASE ID RELEASE 59%8847453 Synthesis of PIPs in the nucleus Pip4k2b Tmem55b Pip4k2a Pip4k2c METABOLISM OF LIPIDS AND LIPOPROTEINS%REACTOME%R-HSA-556833.3 Metabolism of lipids and lipoproteins Ormdl2 Lss Pik3c3 Vapb Cyp21a1 Ppap2c Mvk Acat1 Ormdl1 Ugcg Mtf1 Srebf2 Dpep1 Pmvk Dpep2 Cbr1 Pik3r4 Insig2 Dpep3 Nrf1 Insig1 Thrap3 Gba2 Pdss1 Pdss2 Cerk Sqle H2-Ke6 Arntl Hmgcll1 Mogat1 Mogat2 Tbxas1 Cptp Acot9 Hpgds Esyt3 Cyp4a32 Acot7 Cyp11b1 Esyt1 Cyp4f39 Esyt2 Cyp11b2 Cbr4 Cyp51 Osbpl3 Osbpl9 Ahr Osbpl6 Osbpl7 Cyp2j6 Grhl1 Acat2 Nsdhl Osbpl2 Acot11 Arsg Acot12 Acot13 Msmo1 Arsi Cers4 Arsb Mcat Arsa Cers5 Cers6 Acer3 Echs1 Acer1 Cers3 Fhl2 Cers2 Hadhb Arsk Aacs Arsj Acadm Acer2 Hadha Cers1 Hadh Coq6 Mbtps1 Gba Coq5 Mbtps2 Coq9 Olah Idi1 Ocrl Ncoa3 Coq7 Coq3 Cyp4a12b Ap2m1 Med1 Csnk2a2 Sult2a1 Cyp1a2 Ap2a1 Ptgs1 Ap2a2 Cyp1a1 Ctsa Med4 Arnt2 Med8 Med6 Ap2s1 Slc44a3 Ggt5 Slc44a4 Cyp17a1 Slc25a1 Slc44a5 Acot2 Acot3 Cyp2c65 Slc44a1 Acot4 Fdft1 Slc44a2 Med9 Clta Ap2b1 Csnk2b Cyp1b1 Cltc Ugt1a9 Aldh7a1 Ahrr Cyp4f40 Mvd Cyp2c50 Alox12b Abcd1 Hsd17b7 Fads1 Cdk19 Pla2g5 Ptgr2 Acaa1a Pla2g4d Ptgr1 Pla2g4e Enpp7 Pla1a Sgpl1 Pla2g4f Dhcr24 Sptssb Sptssa Ephx2 Eci1 Asah2 Fam120b Stard5 Fa2h Pla2g2e Ch25h Rgl1 Pla2g12a Osbpl8 Gltp Pla2g2d Gk2 Pla2g1b Pon2 Pla2g2f Clock Pon1 Osbpl5 Degs2 Acbd7 Lpcat4 Acbd6 Lpcat3 Pla2g4a Acad12 Pla2g10 Tnfrsf21 Pla2r1 Fads2 Acad10 Scp2 Pla2g16 Acad11 Agk Acaa2 Mboat1 Osbpl10 Pnpla5 Hpgd Prkd3 Acsm3 Sptlc2 Alox5ap Med13l Smpd4 Smpd1 Oxct1 Prkd1 Ran G0s2 Sptlc3 Sptlc1 Prkd2 Med22 Hexa Bdh2 Bdh1 Med28 Med29 B3galnt1 Med21 Med11 Sgms2 Me1 Ltc4s Med19 Decr2 Hsd17b1 Sgms1 Decr1 Ppap2b Ppargc1b Fdps Ppap2a Ankrd1 Ugt8a Ppargc1a Ptgds Ggps1 Ptges Sc5d B4galnt1 Gyk Sphk2 Cyp8b1 Faah Osbp Fgf21 Acadl Hmgcs2 Fam213b Kdsr Tm7sf2 Plin2 Ppm1l Galc Dbi Lbr Kpnb1 Scd1 Acsf2 Csnk1g2 Them5 Pon3 Scap Amn Med18 Mut Alox12 Dhcr7 Hsd11b1 Cubn Hsd11b2 Slc10a2 Mmaa Slc10a1 Gpd2 Hmgcl Ebp Pex11a Npas2 Arv1 Acads Sgpp2 Sgpp1 Helz2 Crls1 Neu1 Neu3 Neu2 Med20 Coq2 Med27 Med26 Med23 Med24 Plin3 Med25 Pomc Havcr2 Apoe Rxra Carm1 Pten Tmem55b Tbl1xr1 Trib3 Far1 Prkacb Ccnc Tead3 Tead1 Awat1 Tead2 Far2 Sp1 Sphk1 Akr1b3 Pik3r6 Pik3r5 Alas1 Pik3cb Pik3cd Fyn Fabp12 Fabp7 Esrra Plin1 Fabp6 Fabp5 Fabp4 Fabp3 Fabp2 Alox8 Fabp1 Fabp9 Alox15 Gpx4 Cav1 Slc27a1 Lipe Sh3kbp1 Abhd5 Pik3ca Crebbp Gpx2 Idh1 A2m Cpt1b Slc25a20 Cpt2 Cpt1a Mid1ip1 Thrsp Prkaca Psap Pip5k1a Alb Acadvl Ppp1cb Srd5a2 Hsd3b1 Hsd3b6 Srd5a1 Srd5a3 Pip5k1b Pip5k1c Tiam2 Sumf2 Sumf1 Pcsk6 Tead4 Pcsk5 Them4 Ppp1ca Mtmr4 Pik3r3 Ncoa1 Pik3r1 Smpd2 Ncoa6 Ncoa2 Pik3r2 Hdac3 Gm2a Prkaa2 Cdk8 Aldh3b1 Lclat1 Nr1h2 Gpx1 Pla2g6 Osbpl1a Taz Ppp1cc Ep300 Vapa Apoa1 Apob Txnrd1 Med31 Glipr1 Nr1d1 Tbl1x Med30 Agt Ctgf Ptgs2 Mgll Glb1 Mcee Cd36 Mttp Apoc1 Apoc4 P4hb Prkag2 Ptges2 Abcb4 Lta4h Med13 Med14 Med12 Acly Alox5 Hexb Med10 Chd9 Med16 Med17 Med15 Abcc3 Fdx1 Fdx1l Star Stard4 Rora Ncor1 Ormdl3 Ncor2 Cyp11a1 Stard3nl Stard3 Fdxr Furin Slc27a5 Cyp46a1 Cyp27a1 Akr1d1 Amacr Hsd3b7 Cyp39a1 Ndufab1 Smarcd3 Ppard Slc27a2 Ppara Pparg Yap1 Asah1 Slco1a4 Wwtr1 Slco1b2 Apoa5 Lipc Smpd3 Pip4k2b Pip4k2a Prkab2 Pip4k2c Gla Pik3cg Degs1 Angptl3 Creb3l3 Angptl4 Ldlrap1 Gm6484 Nfyb Nfyc Akr1c6 Acox2 Ldlr Hsd17b4 Cyp7a1 Cyp7b1 Baat Acot8 Abcb11 Nr1h4 Ppt2 Hsd17b3 Nfya Hacd2 Akr1c18 Hacd3 Apoa4 Hacd1 Ppt1 Acsl3 Acsf3 Akr1c21 Hsd17b12 Apoa2 Hacd4 Acsbg1 Acsl6 Acsl5 Fasn Acsl4 Elovl7 Acsbg2 Slc27a3 Acsl1 Elovl6 Tecr Mapkapk2 Tecrl Elovl1 Elovl5 Pnlip Elovl4 Elovl3 Elovl2 Sec24a Sec24b Sec24d Sec24c Clps Mfsd2a Dgat2 Chkb Gde1 Pi4kb Pld3 Etnppl Bmx Apoc2 Cept1 Apoc3 Rab5a Dgat2l6 Mtmr2 Gpihbp1 Chat Mtmr1 Dgat1 Ptgis Chka Mtmr3 Lpl Tnfaip8l2 Mtmr7 Acacb Mtmr6 Tnfaip8 Inppl1 Tnfaip8l1 Pcca Acaca Gnpat Tnfaip8l3 Inpp5k Pgs1 Pitpnm1 Pccb Abhd4 Vac14 Pcyt2 Abhd3 Lpcat1 Plekha5 Abcc1 Plekha6 Lpgat1 Plekha8 Bhmt Synj2 Plekha1 Sin3a Plekha2 Pld2 Pi4ka Pld1 Gpd1l Plb1 Synj1 Pld4 Gpcpd1 Plekha3 Npc1 Cpne3 Npc2 Acp6 Cyp2u1 Pemt Sar1b Cpne1 Hdlbp Gpd1 Soat1 Pi4k2b Soat2 Ggt1 Cpne7 Lmf2 Cpne6 Lmf1 Pik3c2b Pik3c2a Mtm1 Hsd17b14 Pik3c2g Cyp4f18 Enpp6 Sec23a Mboat2 Cyp4f17 Mboat7 Cga Chdh Lhb Pnpla2 Cds2 Cyp4f15 Arnt Agpat6 Agpat5 Cyp4b1 Cyp19a1 Etnk1 Inpp4b Hsd17b11 Pnpla8 Hsd17b2 Inpp4a Akr1b8 Arf1 Tpte Pikfyve Arf3 Fig4 Phospho1 Pnpla3 Pnpla6 Awat2 Alpi Reln Rab14 Lipk Gpam Cdipt Abca1 Fitm1 Lpcat2 Fitm2 Lpin2 Lipa Plbd1 Apof Ept1 Ces3b Pitpnb Inpp5d Pnliprp1 Abcg1 Pitpnm2 Stard10 Zdhhc8 Lsr Pitpnm3 Lipf Pi4k2a Lipg Hrasls5 Inpp5f Liph Inpp5e Lipn Ptdss2 Cidec Ptdss1 Cidea Abcg5 Hrasls Rufy1 Mylip Ddhd1 Dab1 Abcg8 Sacm1l Pnliprp2 Ptpn13 Ache Nr1h3 Lpin3 Hsd17b13 Pla2g3 Pcsk9 Apobr Lpin1 Lcat Stard7 Nceh1 Dmgdh Hilpda Mtmr14 Pcyt1a Vldlr Cel Pcyt1b Acbd4 Ehhadh Hacl1 Acbd5 Nudt7 Acox3 Slc25a17 Agps Hao2 Mlycd Acoxl Nudt19 Crot Pecr Crat Phyh Gdpd1 Sardh Pctp Gdpd5 Rab4a Cds1 Bche Tmem86b Pla2g4c Agpat3 Agpat4 Agpat1 Agpat2 Pisd Pnpla7 Agpat9 Chpt1 Gdpd3 Gpat2 ENZYMATIC DEGRADATION OF DOPAMINE BY MONOAMINE OXIDASE%REACTOME%R-HSA-379398.2 Enzymatic degradation of Dopamine by monoamine oxidase Comt Maoa FREE FATTY ACID RECEPTORS%REACTOME DATABASE ID RELEASE 59%444209 Free fatty acid receptors Gpr31b Ffar3 Ffar4 Ffar2 Ffar1 POST-TRANSLATIONAL PROTEIN MODIFICATION%REACTOME DATABASE ID RELEASE 59%597592 Post-translational protein modification Hdac7 Ube2t Hspa8 Ino80 Parp1 Ino80c Ino80b Ino80e Ino80d Nfrkb Tnks Polb Tnks2 Actl6a Tfpt Actr8 Actr5 F2 Tgfbr1 Tgfbr2 Mdm4 Gas6 Bard1 Kat2b Kat2a Apc Axin1 Rraga Chm Ube2d1 Cdc20 Ube2c Ube2e1 Park2 Josd2 Atxn3 Ccp110 Rab8a Cetn2 Yy1 Rab11a Csnk1d Taf9b Dynll1 Dync1i2 Dctn2 Esr1 Dctn3 Tnfaip3 Usp21 Rab27b Cd109 Gfpt1 Dync1h1 Ube2d3 Blm Otud7b Usp2 Usp4 Cyld Mdc1 Srd5a3 Tfap2b Tgfb1 Tfap2c Wrn Dag1 Adamts5 Uchl5 Brca1 Nedd8 Usp15 Vdac1 Dph3 Dph2 Dph1 Dph7 Dph6 Dph5 Ar Atxn7 Rft1 Ubxn1 Foxo4 Vdac2 Vdac3 Proz Nagk Smad1 Gcnt7 Pomt1 Pomgnt2 Pomt2 Zranb1 Pomgnt1 Dhps Usp12 Nsmce2 Ddb2 Usp11 Rab38 Sbspon Cdc34 Nsmce1 Cmas Smad4 Rab32 Smad2 Usp19 Smad7 Rab31 Usp13 Usp14 Mbd6 Aurka Smad3 Usp16 Rab19 Rab17 Engase Rab12 Rab13 Rab10 Ep300 Rab20 Rab21 Rab29 Ube2i L3mbtl2 Rab23 Rab24 Rab25 Rab26 Pml Calr Pdia3 Eif5a Ube2z Ube2w Glb1 Gfpt2 Ube2k Gcnt1 Ube2h Foxk1 Gcnt3 Foxk2 Pcgf2 B3gnt3 B3gnt2 B3gnt7 B3gnt6 B3gnt5 B3gnt4 B3gnt9 B3gnt8 Gnpnat1 Alg10b F9 Nudt14 F7 Alg5 F10 Pros1 Usp9x Rab36 Rab30 Rab33b Psmf1 Proc Rab39 Psme4 Skp2 Psme3 Rabggta Rabggtb Furin Usp7 Rab27a Psma7 Psmb5 Psmb4 Ubc Psmb7 Myc Psmb6 Psmb2 Cdkn2a Psmb3 Psmb1 Trp53 Psme2 Psme1 Psmb10 Smurf2 Psmb11 Usp8 Rhoa Eef2 Nop58 Rpn2 Ripk1 Rab5a Gata3 Traf2 Rpn1 Alppl2 Derl1 Prkdc Rce1 Ube2r2 Hist1h2aa Otud7a Ube2q2 Hnrnpc Adrm1 Mettl21a St6gal2 Actb Uap1 Chst4 B3galnt2 Mat2b Hist1h2af Asxl2 Asxl1 Mavs Magt1 Otulin Fuk Rab22a B4galnt2 Rnf2 Nsmce4a Hist3h2a Hnrnpk Hcfc1 Kin Hist2h2ab Gmppa Gmppb Adamts13 Rtf1 Adamts14 Adamts15 Arsg Thsd7a Arsi Arsb Arsa Dad1 Ide Hist2h2bb Usp5 Stambpl1 Rpa1 Arsk Hist2h2be Arsj Uchl3 Hist2h2ac Tomm70a Thsd7b Tsta3 Usp3 Hist1h2bg Gyltl1b Hist1h2bh Rnf135 Camkmt Paf1 Vcpkmt Asgr1 Large Fuom Hist1h2bp Asgr2 Hist1h2bm Rnf146 Otud3 Hist1h2bj Ube2e3 Hist1h2bb Kdm1b Tusc3 Wdr20 Rnf123 Mpi Ctsa Rnf128 Pofut2 Wdr48 Stambp Eif5a2 Phc3 Ptrh2 Tada3 Yod1 Rnf181 Phc2 Phc1 Galnt12 Galnt13 Galnt10 Hist1h2ak Galnt11 Galnt16 Galnt18 Hist1h2ag Galnt14 Galnt15 Trrap Rnf152 Otub2 Mvd Otub1 Otud5 Hist1h2ah Sema5b Nup50 Pias4 Tpr Pias3 Ndc1 Nup214 Top2b Aaas Nup210 Nup188 Nup54 Nup35 Nupl2 Nup62 Nup205 Ddost Nup155 Nup88 Pom121 Top1 Rae1 Nup93 Sumo3 Nup153 Mogs Rnf144a Adrb2 Rab3a Rab33a Wbscr17 Becn1 Rab5c Rab5b Dpagt1 Usp42 Usp44 Arrb2 Traf3 Usp47 Arrb1 Usp48 Usp49 Ngly1 Neu1 Siah2 Fn3k Neu3 Neu2 Neu4 Rab3c Il33 Usp37 Usp33 Usp28 Rab3d Usp30 Rab3b Nus1 Spon2 Slc17a5 Rab4b Galntl5 Suds3 Fn3krp Spon1 Mpdu1 Rab37 Rab34 Rab35 Wdr61 Usp26 Usp20 Mta1 Rab42 Usp25 B3gntl1 Rab2b Ggcx Usp22 Thsd4 Dhdds Thsd1 Gmds Mettl20 Mysm1 Psmd12 Mettl22 Psmd11 Keap1 Rab9 Sspo Fkbp8 Psmd14 Smc5 Mul1 Smc6 Psmd13 Renbp Psmd10 Ptp4a2 Rab11b Pgm3 B3glct Ctr9 Cfp Rab43 Prmt3 Cdc73 Rab39b Fpgt Chml Stt3a Rab8b N6amt2 Rab7 Shfm1 A4gnt Cbx4 Eef2kmt Rab9b Cbx8 Cbx2 Mdm2 Galnt1 Pmm2 Pten Galnt2 Pmm1 Leo1 Bmi1 Rab18 Senp8 Galnt7 Galnt3 Galnt6 Rab6b Rab6a Senp5 Galnt4 Galnt5 Psmc6 Fam175b St6galnac6 St6galnac5 Psmc5 St6galnac4 St6galnac3 Umod Etfb Canx Psmc2 Ganab Psmd2 Rab40c Rab40b Icmt Psmb9 Uba6 Psmb8 Mitf Alg11 Alg14 Psmc1 Kcna6 Psmc4 Psmc3 Senp1 Ring1 Senp2 C1galt1c1 Mlec Bcl10 Gne Sp3 Dnajc24 Npl Amdhd2 Ndnl2 Adamts3 Nans Nanp Adamts6 Hist3h2ba Adamts7 Adamts2 Alg3 Alg6 Thbs1 Alg8 Prkcsh Alg9 Alg1 Alg2 Mettl10 Dolpp1 Thbs2 Adamts12 Dolk Adamts19 Axin2 Adamts10 Wac Cftr Pomk Uchl1 Psma5 Psma4 Ifih1 Psma3 Adamts20 Psma6 C1galt1 B4gat1 St6galnac1 Psma2 Psma1 St6galnac2 Psmd9 Adamtsl3 Adamtsl4 Adamtsl1 Adamtsl2 Sumf2 Sumf1 Hist2h2aa1 St8sia1 Ube2g2 Psmd1 Ube2g1 Rhot1 Snx3 Dohh Adamtsl5 Rnf20 Tnip1 Psmd3 St3gal1 Psmd4 St3gal2 Ogt Psmd6 St8sia5 Psmd5 Rnf40 St8sia4 Sae1 Psmd7 Ube2l3 Uba1 Uba2 Nlrp3 Psmd8 Ddx58 St3gal5 Tnip3 St3gal6 Ube2b Nup85 Ufd1l Vcp Nup160 Ube2a Trim25 Tnip2 Nod2 Nod1 Hif1a Map3k7 Tab1 Ripk2 Aurkb Cdca8 Stag2 Nfkbia Stag1 Usp10 Nup107 Smc1a Rad21 Birc5 Nup37 Incenp Nup43 Ruvbl1 Nup133 Smc3 Adamts4 Adamts1 Adamts8 Adamts18 Ranbp2 Adamts16 Fam175a Xpnpep2 Spaca4 Pcna Lsamp Negr1 Clspn Mdga2 Pigw Rnf168 Msln Ntm Brcc3 Trp53bp1 Ccna1 Uimc1 Cdc25a Ccna2 Babam1 Top2a Ly6k Sprn Nrn1 Izumo1r Psca Dpm1 Tex101 Dpm2 Dpm3 Gpld1 Prnd Opcml Lypd4 Lypd3 Lypd2 Cntn3 Pigv Mdga1 Pigx Otoa Pign Pigo Ly6g6d Cpm Ly6e Ly6d Ly6g6c Pigs Ly6h Pigu Plaur Pigt Pigc Tecta Prss41 Pigb Pigf Pigg Nrn1l Pigh Thy1 Reck Ntng1 Rtn4rl1 Rtn4rl2 Gp2 Piga Tectb Art4 Art3 Lypd5 Alpl Lypd8 Lypd1 Lypd6b Pigk Pigm Pigl Prss21 Pgap1 Gpaa1 Mfi2 Cntn5 Rad52 Herc2 Usp18 Bre Bap1 Xrcc4 Chst8 Os9 Rnf185 Derl2 Rnf5 Rnf139 Man1b1 Uggt2 Edem3 Rab2a Amfr Trim13 Uggt1 Edem2 Edem1 Rnf103 Syvn1 Sel1l March6 Trappc2 Tgfa Trappc3 Ins2 Mgat5 Mcfd2 Trappc1 Bst1 Rab1 F5 Preb Copa F8 Sec24a Sec24b Sptan1 Sec13 Chst10 Tmed3 Mgat4a Mgat4b Sec24d Scfd1 Gria1 Sec24c Man2a1 Fut8 Stam Arcn1 Hgs Tfg St6gal1 Ykt6 Stam2 Cd59b Mgat4c Cog6 Lman2l Cog3 Cog4 Cog2 St8sia3 Sec31a Cog1 Ctage5 Gorasp1 Nsf Gpihbp1 St8sia2 Trappc6a St8sia6 Trappc6b Tmed9 Man1c1 Bet1l Gbf1 Ankrd28 St3gal4 Man1a Trappc9 Mgat3 Napb Napg Mgat2 Mgat1 Napa Trappc5 Spta1 Trappc4 Sptbn4 Dctn5 Dctn6 Ctsz Birc3 Folr2 Birc2 Dctn1 Serpina1d Col7a1 Traf6 Sema5a Lman1l Dctn4 Areg Ube2n Serpina1a Dync1li2 Folr1 Dync1li1 Man1a2 Ikbkg Rab1b Ppp6r1 Ppp6r3 Arf5 Cnih1 Kdelr2 Kdelr3 Uso1 Bet1 Stx17 Cnih3 Vnn3 Ctsc Cnih2 Cog7 Tmem115 Vnn1 Cog8 Fuca1 Arfgap3 Arfgap1 Arfgap2 Sar1b Golgb1 Copb2 Stx5a Manea Copb1 Ppp6c Copz1 Ank1 Ank3 Sec23a Copz2 Cga Lhb Trappc10 Sec23ip Copg1 Gosr1 Golga2 Dynll2 Gosr2 Arf1 Kdelr1 Arf3 Arf4 Dync1i1 Sptbn2 Trappc2l Alpi Sptbn1 Rab14 B4galt3 Tbc1d20 B4galt1 Pias1 Cope Rad23a B4galt5 B4galt4 Rad23b B4galt6 Xpc B4galt2 Sec16b Sec22a Lman1 Sec22b Sptb Muc1 Muc4 Lman2 Sec16a Sec22c Muc15 Muc20 Muc13 Rab4a Slc35a1 Slc35c1 THE AIM2 INFLAMMASOME%REACTOME%R-HSA-844615.1 The AIM2 inflammasome Aim2 Pycard Casp1 NOD1 2 SIGNALING PATHWAY%REACTOME DATABASE ID RELEASE 59%168638 NOD1 2 Signaling Pathway Casp9 Casp8 Chuk Tnfaip3 Itch Casp4 Cyld Nod2 Nod1 Map3k7 Irak2 Irak1 Birc3 Birc2 Tab1 Map2k6 Tab2 Traf6 Tab3 Ikbkb Ube2v1 Card9 Ripk2 Ube2n Ikbkg Mapk11 Mapk13 Mapk12 Mapk14 Casp1 Casp2 TP53 REGULATES TRANSCRIPTION OF SEVERAL ADDITIONAL CELL DEATH GENES WHOSE SPECIFIC ROLES IN P53-DEPENDENT APOPTOSIS REMAIN UNCERTAIN%REACTOME%R-HSA-6803205.1 TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain Perp Trp53bp2 Birc5 Trp53 Trp63 Bcl2l14 Rabggta Ppp1r13b Rabggtb Bcl6 Ndrg1 Chm Trp73 PROTEIN-PROTEIN INTERACTIONS AT SYNAPSES%REACTOME DATABASE ID RELEASE 59%6794362 Protein-protein interactions at synapses Gria3 Gria4 Grin1 Dlg4 Syt10 Dlgap4 Nlgn3 Syt12 Grin2c Dlgap1 Apba2 Dlgap3 Dlgap2 Shank1 Dlg2 Shank3 Nrxn2 Nlgn1 Nlgn2 Dbnl Homer3 Syt9 Syt7 Nrxn1 Epb4.1 Begain Gria1 Syt2 Grin2d Grin2b Dlg1 Dlg3 Epb4.1l3 Stxbp1 Epb4.1l2 Epb4.1l5 Grm1 Cask Sipa1l1 Grm5 Lrrtm3 Sharpin Lrrtm1 Lrrtm2 Pdlim5 Grin2a Apba3 Homer1 Homer2 Lin7b Lrfn2 Lrfn3 Ptprf Apba1 Flot2 Flot1 Lrfn4 Rtn3 Syt1 Lin7c Ptprs Lin7a Stx1a RESPIRATORY ELECTRON TRANSPORT%REACTOME DATABASE ID RELEASE 59%611105 Respiratory electron transport Ndufs5 Ndufs4 Ndufa13 Ndufs2 Ndufb11 Ndufb10 Etfb Ndufs7 Ndufs8 Ndufa11 Ndufs1 Ndufa10 Ndufa12 Ndufb2 Acad9 Ndufc2 Ndufc1 Ecsit Ndufb4 Ndufb3 Ndufb6 Cox4i1 Ndufb5 mt-Nd2 mt-Nd1 Timmdc1 Nubpl mt-Nd6 mt-Nd5 mt-Nd4 mt-Nd3 Ndufaf1 Ndufaf2 Ndufaf3 Ndufa1 Ndufa2 Ndufa3 Ndufa5 Lrpprc Ndufaf4 Ndufb9 Ndufb7 Yjefn3 Ndufb8 Tmem126b Cox6a1 Ndufv3 Ndufv1 Ndufv2 mt-Co1 Cyc1 Ndufab1 Ndufa6 Ndufa7 Ndufaf5 Ndufaf6 Ndufa8 Ndufa9 Cox6b1 Ndufaf7 Cox8a Cox20 Uqcrc2 mt-Co3 Uqcrc1 mt-Co2 Uqcrfs1 Etfa Coq10b Uqcrb Coq10a Trap1 Uqcrq Cox7a2l Etfdh mt-Cytb Uqcr10 Cox14 Cox7b Cox11 Cox16 Sco1 Ndufa4 Cox18 Taco1 Sdhd Sdha Cox5a Sdhc Sdhb Surf1 REGULATION OF MITOTIC CELL CYCLE%REACTOME DATABASE ID RELEASE 59%453276 Regulation of mitotic cell cycle Psmc6 Psmc5 Nek2 Psmc2 Psmd2 Psmb9 Psmf1 Psmb8 Btrc Psme4 Cdk2 Cdk1 Skp1a Psmc1 Ccna1 Psmc4 Skp2 Psmc3 Cul1 Ccna2 Psme3 Anapc15 Anapc11 Anapc10 Fzr1 Fbxo5 Aurkb Aurka Pttg1 Bub1b Psmd12 Plk1 Psma7 Psmd11 Psmd14 Psma5 Psmb5 Psmb4 Ubc Psmd13 Bub3 Psmd10 Psma4 Psmb7 Psma3 Psma6 Psmb6 Psmb2 Mad2l1 Psmb3 Psmb1 Psma2 Psma1 Cdc23 Psmd9 Ube2d1 Cdc27 Cdc14a Cdc16 Cdc20 Ube2c Anapc16 Ube2e1 Anapc7 Psmd1 Shfm1 Anapc4 Psme2 Anapc5 Anapc1 Psme1 Anapc2 Psmd3 Psmd4 Psmb10 Psmd6 Psmd5 Psmd7 Psmb11 Psmd8 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION%REACTOME%R-HSA-416550.1 Sema4D mediated inhibition of cell attachment and migration Sema4d Rac1 Rhoa Rras Plxnb1 Met Arhgap35 Rnd1 DOWNSTREAM SIGNALING OF ACTIVATED FGFR1%REACTOME%R-HSA-5654687.2 Downstream signaling of activated FGFR1 Fgf23 Flrt3 Fgf22 Kras Fgf20 Frs2 Nras Frs3 Flrt2 Flrt1 Plcg1 Hras Pik3ca Sos1 Fgf1 Gab1 Fgf2 Fgf9 Pik3r1 Ptpn11 Fgf6 Fgf10 Fgf4 Fgf3 ORGANIC CATION TRANSPORT%REACTOME DATABASE ID RELEASE 59%549127 Organic cation transport Slc22a16 Slc22a15 Slc22a2 Slc22a18 Slc22a1 Slc22a3 Slc22a4 Slc22a5 FANCONI ANEMIA PATHWAY%REACTOME%R-HSA-6783310.2 Fanconi Anemia Pathway Fancb Fancl Fancg Fanca Fancm Ube2t 2310003H01Rik Dclre1b Dclre1a Stra13 Zbtb32 Trex1 Eme1 Ubc Fancd2 Atrip Slx4 Mus81 2610002J02Rik Fan1 Apitd1 C230052I12Rik Rpa2 Rpa1 Poln Usp1 Rpa3 Fancc Fanci Ercc4 Ercc1 Fancf SIGNALING BY INTERLEUKINS%REACTOME DATABASE ID RELEASE 59%449147 Signaling by Interleukins Hspa8 Vegfa Hist1h3d Hist2h3c1 Skp1a Csk Cul1 Gab2 Stx1a Actn2 Nf1 Pdgfrb Stat5b Pdgfra Stat5a Kbtbd7 Vav1 Pou2f1 Il2rg Arrb2 Egfr Arrb1 Ret Vwf Il33 Map2k6 Sox2 Mmp2 Mmp9 Pspn Map2k1 Rbx1 Crkl Fgg Cdkn1a Map2k2 Cul3 Psmd12 Pdgfb Psmd11 Rasgef1a Psmd14 Rasa3 Rasa4 Psmd13 Psmd10 Itgb2 Il2 Rasa2 Itgam Rasa1 Pomc Nefl Spred3 Kit Spred2 Grin2a Spred1 Il5 Ppp2r1b Ywhab Junb Kras Gdnf Shfm1 Irs2 Lck Syngap1 Cd4 Hbegf Irs1 Ptpn6 Il3ra Btc Casp1 Il2ra Il2rb Ptpn11 Angpt1 Vim Maoa Psmc6 Egf Fgf23 Psmc5 Fgf22 Hmox1 Mark3 Psmc2 Fgf20 Psmd2 Dab2ip Tek Psmb9 Hsp90aa1 Psmb8 Araf Hras Grin1 Ppp2r5e Bcl6 Dlg4 Ppp2r5c Ppp2r5d Ppp2r5a Psmc1 Psmc4 Psmc3 Pik3cb Foxo3 Pik3cd Foxo1 Itgb3 Hck Fyn Phb Grin2c Stat1 Rasgrp4 Rasgrp3 Stat6 Pebp1 S1pr1 Alox15 Blnk Ppp2r5b Syk Rasgrp1 Tln1 Pik3ca Fga Fos Fgb Grin2d Prkaca Grin2b Hgf Gfra2 Gfra3 Lcn2 Gfra4 Ywhaz Ereg Jak2 Pea15a Itga2b Rap1a Jak3 Wdr83 Camk2d Rap1b Camk2a Fgfr4 Camk2b Psma5 Rasal3 Rasal2 Psma4 Psma3 Oprd1 Psma6 Vcl Camk2g Psma2 Psma1 Gfra1 Lama5 Mmp1a Psmd9 Dusp7 Iqgap1 Fgf16 Dusp6 Tgfb1 Dusp9 Fgf15 Dusp8 Klb Fgf18 Itgax Sqstm1 Psmd1 Met Fn1 Rasal1 Dusp1 Psmd3 Psmd4 Psmd6 Psmd5 Dusp2 Nos2 Pik3r3 Mmp3 Psmd7 Crk Pik3r1 Dusp5 Psmd8 Fgf10 Rhou Pik3r2 Dusp4 Il31ra Il22ra1 Akap9 Ppp2r1a Btrc Nfkb2 Nfkb1 Fbxw11 Saa3 Tnip2 Il22ra2 Myd88 Nod2 Nod1 Hif1a Map3k7 Irak3 Hsp90b1 Peli1 Irak2 Irak1 Tab1 Twist1 Tab2 Tab3 Lifr Ripk2 Map2k4 Map3k8 Rela Il4 Il6 Csf3 Csf2 Ccl12 Peli3 Tnfrsf1a Csf3r Csf1 Irak4 Peli2 Fcer2a Col1a2 Csf1r Tnfrsf1b Lif Cd86 Ptk2b Ccl5 Ccl4 Birc5 Tnf Jak1 Osm Fpr1 Timp1 Il12b Stx4a Ccr1 Brwd1 Il12a Il10 Ccl3 Il13 Cd80 Il27ra Il1rn Anxa1 Ptafr Tyk2 Casp3 Stat3 Il10ra Icam1 Cxcl3 Cxcl1 Ptgs2 Il1r2 Il1f10 Ccl22 Il1r1 Ccl20 Ccr2 Ccr5 Il1b Cxcl10 Il1a Il18 Il18rap Map3k3 Il17f Il17a Il17c Il10rb Il17rb Il17ra Cd36 Il17re Il17rc Oprm1 F13a1 Mcl1 Il13ra2 Il13ra1 Zeb1 Il27 Frs2 Nras Prtn3 Frs3 Rasgrf1 Flt3 Psmf1 Raf1 Ctf1 Psme4 Alox5 Il5ra Fgf1 Osmr Il17rd Fgf2 Cnksr1 Cnksr2 Erbb2 Fgf9 Ptk2 Fgf7 Psme3 Fgf6 Rorc Fgf4 Fgf3 Ccnd1 Rora Flt3l Stx3 Ppp5c Ranbp9 Batf Ppp2cb Shc1 Lamtor2 Ifnlr1 Chuk Nrg2 Ppp2ca Shc3 Nrg1 Ndn Il1f9 Shc2 Il1f6 Psma7 Artn Cntf Il1f8 Nrtn Brap Il7r Psmb5 Psmb4 Ubc Nrg3 Cntfr Myc Psmb7 Pim1 Nrg4 Fscn1 Psmb6 Psmb2 Psmb3 Il9r Psmb1 Mapk3 Akt1 Mapk1 Ksr1 Ptpra Il6ra Dusp16 Dusp10 Ebi3 Map3k11 Il1rl1 Il1rl2 Trp53 Vcam1 Iltifb Paqr3 Il15 Il11 Psme2 Il6st Crlf1 Psme1 Ncam1 Sos1 Il16 Il19 Braf Psmb10 Apbb1ip Il34 Rapgef1 Il15ra Psmb11 Csf2rb2 Tec Il20 Rapgef2 Csf2ra Il25 Il24 Sptan1 Fasl Smarca4 Yes1 Lyn Cbl Inppl1 Socs1 Socs5 Gata3 Il12rb1 Il12rb2 Spta1 Sptbn4 Bcl2 Bcl2l1 Traf6 Ikbkb Ube2v1 Ube2n Ikbkg Il4ra Itgb1 Irf4 Il18r1 Sptbn2 Sptbn1 Il18bp Tollip Inpp5d Lbp Ifnl3 Sptb Muc1 Il11ra2 Il23r Il23a Il9 Clcf1 Socs3 Il20rb Il20ra Rag2 Rag1 Gm13305 Txlna Il7 Ccl11 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES%REACTOME DATABASE ID RELEASE 59%1650814 Collagen biosynthesis and modifying enzymes Plod3 Col28a1 Plod2 Plod1 Pcolce2 Col24a1 Col20a1 P3h3 Col27a1 P4ha2 P4ha3 Col10a1 P4ha1 Col3a1 Crtap Colgalt1 Colgalt2 Col11a1 Adamts14 Serpinh1 Col11a2 P3h2 P3h1 Col8a1 Col8a2 Col5a1 Ppib Col22a1 Col4a6 Col5a3 Col5a2 Adamts3 Col4a3 Col4a2 Col4a4 Col4a1 Col17a1 Adamts2 Col2a1 Col1a2 Col1a1 Col4a5 Col16a1 Col15a1 Col9a1 Col9a2 Col9a3 Tll1 Col25a1 Pcolce Tll2 Col23a1 Col7a1 Bmp1 Col26a1 Col6a1 Col12a1 P4hb Col6a2 Col13a1 Col6a3 Col6a6 Col14a1 Col19a1 Col18a1 PHOSPHO-PLA2 PATHWAY%REACTOME DATABASE ID RELEASE 59%111995 phospho-PLA2 pathway Pla2g4a Mapk1 LIGAND-RECEPTOR INTERACTIONS%REACTOME DATABASE ID RELEASE 59%5632681 Ligand-receptor interactions Gas1 Boc Hhip Ihh Shh Dhh Cdon Ptch1 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT%REACTOME%R-HSA-159231.2 Transport of Mature mRNA Derived from an Intronless Transcript Fip1l1 Nup85 Sympk Nup160 Nup37 Nup50 Tpr Nup43 Nup133 Cpsf3 Cpsf2 Nxf1 Cpsf4 Ndc1 Nup214 Aaas Nup210 Nup188 Nup54 Nup35 Nupl2 Nup62 Wdr33 Nup205 Nup155 Nup88 Pom121 Rae1 Nup93 Nup153 Eif4e Cpsf1 Ranbp2 Nup107 Ncbp1 Ncbp2 Alyref RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+%REACTOME%R-HSA-76005.2 Response to elevated platelet cytosolic Ca2+ Actn2 Serpine1 Tgfb3 Prkcg Tgfb2 Plg Brpf3 Prkcb Prkca Pfn1 Vwf Sytl4 Fermt3 Apoh Wdr1 Serping1 App Srgn Gas6 Serpinf2 F5 Fam49b F8 Actn1 Cyb5r1 Maged2 A1bg Lgals3bp Nhlrc2 Pcyox1l Actn4 Calu Endod1 Fam3c Lhfpl2 Manf Chid1 Aplp2 Habp4 Pcdh7 Apool Cdc37l1 Serpina3n Apoa1 Tor4a Islr Timp1 Fgg Stx4a Pdgfb Vegfa Aldoa Serpina1d Trf Serpina1a Cd36 F13a1 Egf Pros1 Stxbp3 Pf4 Itgb3 Tuba4a Tln1 A2m Fga Fgb Thbs1 Hgf Tex264 Psap Ahsg Alb Cfd Abcc4 Cap1 Ola1 Igf2 Itga2b Clec3b Igf1 Ctsw Rab27b Hrg Selp Cd109 Hspa5 Scg3 Stxbp2 Lamp2 Flna Sccpdh Phactr2 Sepp1 Gtpbp2 Clu Tagln2 Tmx3 Timp3 Pecam1 Vcl Ttn Spp2 Orm3 Cd9 Plek Vti1b Qsox1 Ppia Kng2 Ecm1 Mmrn1 Lefty2 Anxa5 Itih3 Rarres2 Ppbp Tgfb1 Cd63 Itih4 Fn1 Sparc Vegfb Vegfc Figf REVERSE TRANSCRIPTION OF HIV RNA%REACTOME%R-HSA-162589.1 Reverse Transcription of HIV RNA Ppia SUMO E3 LIGASES SUMOYLATE TARGET PROTEINS%REACTOME%R-HSA-3108232.3 SUMO E3 ligases SUMOylate target proteins Nup85 Hnrnpc Nup160 Nup50 Pias4 Tpr Pcna Pias3 Rnf168 Ndc1 Nup214 Top2b Aaas Nup210 Mitf Nup188 Cetn2 Nup54 Nup35 Trp53bp1 Nupl2 Rnf2 Nup62 Nup205 Nsmce4a Nup155 Nup88 Pom121 Hnrnpk Top1 Top2a Rae1 Nsmce2 Ring1 Nup93 Nsmce1 Sumo3 Nup153 Aurkb Sp3 Cdca8 Aurka Ndnl2 Stag2 Stag1 Rpa1 Pias1 Nup107 Xpc Hdac7 Smc1a Mta1 L3mbtl2 Rad21 Ube2i Nop58 Birc5 Nup37 Pml Incenp Nup43 Nup133 Smc5 Parp1 Blm Smc6 Cdkn2a Mdc1 Smc3 Tfap2b Rad52 Herc2 Phc3 Tfap2c Trp53 Wrn Phc2 Phc1 Brca1 Cbx4 Pcgf2 Cbx8 Mdm2 Cbx2 Ranbp2 Bmi1 Xrcc4 DIGESTION OF DIETARY LIPID%REACTOME DATABASE ID RELEASE 59%192456 Digestion of dietary lipid Clps Lipk Lipc Pnlip Lmf2 Lmf1 Pnliprp1 Lipf Lipg Liph Lipn Pnliprp2 Cel THYROXINE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 59%209968 Thyroxine biosynthesis Tpo Slc5a5 Duox2 Dio3 Iyd Dio2 Duox1 Tshb Dio1 Cga RNA POLYMERASE I PROMOTER OPENING%REACTOME DATABASE ID RELEASE 59%73728 RNA Polymerase I Promoter Opening Hist1h2bg H2afb2 Hist1h2bh Mbd2 Hist2h2aa1 Hist1h2bp Ubtf Hist1h2bm Hist1h2bj Hist1h3d Hist1h2bb Hist2h3c1 Hist1h2ak Hist3h2ba Hist2h2be Hist1h2ag H2afz Hist2h2ac H2afx Mapk3 H3f3b H3f3a Hist1h2ah H2afj ASSEMBLY OF THE HIV VIRION%REACTOME%R-HSA-175474.1 Assembly Of The HIV Virion Furin Ubc Vps37d Tsg101 Vps37c Vps37b Nmt2 Vps37a Tonsl Ppia ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS%REACTOME%R-HSA-983695.1 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Srms Btk Plcg1 Cd79b Vav1 Lyn Cd79a Cbl Nck1 Pik3cd Cd19 Fyn Stim1 Cd22 Trpc1 Orai1 Orai2 Dapp1 Plcg2 Blk Pik3ap1 Blnk Cblb Syk Sh3kbp1 Sos1 Itpr1 Ptpn6 Ahcyl1 Pik3r1 Itpr3 Itpr2 P75NTR RECRUITS SIGNALLING COMPLEXES%REACTOME DATABASE ID RELEASE 59%209543 p75NTR recruits signalling complexes Ngf Prkci Irak1 Ubc Traf6 Ikbkb Ripk2 Myd88 Sqstm1 Ngfr REDUCTION OF CYTOSOLIC CA++ LEVELS%REACTOME DATABASE ID RELEASE 59%418359 Reduction of cytosolic Ca++ levels Atp2b3 Atp2a1 Atp2b4 Slc8a3 Atp2b1 Atp2a3 Atp2a2 Atp2b2 Sri Slc8a2 Slc8a1 CHOLESTEROL BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 59%191273 Cholesterol biosynthesis Cyp51 Hsd17b7 Lss Tm7sf2 Mvk Acat2 Nsdhl Fdft1 Dhcr24 Pmvk Lbr Msmo1 Dhcr7 Fdps Sqle Ggps1 Ebp Sc5d Mvd Idi1 Arv1 DEFECTIVE ACTH CAUSES OBESITY AND PRO-OPIOMELANOCORTININ DEFICIENCY (POMCD)%REACTOME DATABASE ID RELEASE 59%5579031 Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Mc2r Pomc SMAC-MEDIATED DISSOCIATION OF IAP:CASPASE COMPLEXES%REACTOME DATABASE ID RELEASE 59%111464 SMAC-mediated dissociation of IAP:caspase complexes Casp3 Diablo Casp9 Casp7 Xiap TOXICITY OF BOTULINUM TOXIN TYPE G (BONT G)%REACTOME DATABASE ID RELEASE 59%5250989 Toxicity of botulinum toxin type G (BoNT G) Vamp1 Syt1 Vamp2 SIGNALLING TO ERKS%REACTOME%R-HSA-187687.1 Signalling to ERKs Akap9 Ppp2r1a Mapkapk3 Csf2 Jak1 Frs2 Nras Frs3 Rasgrf1 Psmf1 Raf1 Psme4 Il5ra Fgf1 Il17rd Fgf2 Cnksr1 Csk Cnksr2 Erbb2 Fgf9 Ptk2 Fgf7 Psme3 Fgf6 Fgf4 Fgf3 Ppp5c Ranbp9 Ppp2cb Shc1 Lamtor2 Nrg2 Ppp2ca Shc3 Nrg1 Shc2 Psma7 Artn Nrtn Plcg1 Brap Psmb5 Psmb4 Ubc Nrg3 Psmb7 Nrg4 Psmb6 Psmb2 Psmb3 Psmb1 Mapk3 Mapk1 Ksr1 Ptpra Dusp16 Dusp10 Map3k11 Paqr3 Psme2 Psme1 Ncam1 Sos1 Braf Psmb10 Apbb1ip Rapgef1 Psmb11 Csf2rb2 Rapgef2 Csf2ra Actn2 Nf1 Pdgfrb Pdgfra Kbtbd7 Il2rg Arrb2 Egfr Arrb1 Ret Ntrk1 Vwf Ralb Rala Mapkapk2 Sptan1 Pspn Map2k1 Rbx1 Crkl Fgg Map2k2 Cul3 Psmd12 Pdgfb Psmd11 Rasgef1a Psmd14 Rasa3 Rasa4 Psmd13 Psmd10 Il2 Rasa2 Rasa1 Nefl Spred3 Kit Spred2 Grin2a Spred1 Spta1 Il5 Ppp2r1b Sptbn4 Ywhab Kras Gdnf Shfm1 Irs2 Syngap1 Hbegf Irs1 Il3ra Btc Il2ra Il2rb Angpt1 Psmc6 Egf Fgf23 Psmc5 Fgf22 Mark3 Psmc2 Fgf20 Psmd2 Dab2ip Tek Psmb9 Psmb8 Araf Hras Grin1 Ppp2r5e Dlg4 Ppp2r5c Ppp2r5d Ppp2r5a Psmc1 Psmc4 Psmc3 Sptbn2 Sptbn1 Itgb3 Fyn Phb Grin2c Rasgrp4 Rasgrp3 Pebp1 Ppp2r5b Rasgrp1 Tln1 Fga Fgb Grin2d Grin2b Sptb Hgf Gfra2 Gfra3 Gfra4 Ereg Jak2 Pea15a Itga2b Rap1a Jak3 Wdr83 Camk2d Rap1b Camk2a Fgfr4 Camk2b Psma5 Rasal3 Rasal2 Psma4 Psma3 Psma6 Vcl Camk2g Psma2 Psma1 Gfra1 Rit2 Psmd9 Ngf Dusp7 Iqgap1 Rit1 Fgf16 Dusp6 Ralgds Dusp9 Fgf15 Dusp8 Klb Fgf18 Psmd1 Met Kidins220 Fn1 Mapk11 Rasal1 Dusp1 Mapk13 Psmd3 Mapk12 Psmd4 Mapk14 Psmd6 Psmd5 Dusp2 Psmd7 Crk Dusp5 Psmd8 Fgf10 Dusp4 NEUTROPHIL DEGRANULATION%REACTOME%R-HSA-6798695.2 Neutrophil degranulation Tmem173 Xrcc5 Xrcc6 Iqgap2 Mme Magt1 Rhof Arpc5 Diap1 Arg1 Cybb Cyba Arsb Arsa Hspa1a Hspa8 Sdcbp Ctsh Gdi2 Ap2a2 Hmha1 Nckap1l Ctsa Itgav Aldoc Aldoa Slc44a2 Csnk2b Pfkl Pgam1 Cyfip1 Pgm2 Acaa1a Nfasc Slc2a5 Capn1 Slc2a3 Ddost Pgm1 Clec5a Dera P2rx1 Srp14 Rhog C5ar1 Rock1 Adam10 Snap25 Kpnb1 H2-Q10 Rab3a Txndc5 B2m Gns Ap1m1 Prkcd Rab5c Rab5b Atp6ap2 Cda Neu1 Rab3d Rab4b A1bg Mmp9 Rab37 Serpina3n Ltf Psmd12 S100a9 S100a8 Psmd11 Igf2r Psmd14 Psmd13 Itgb2 Bpi Itgam Fpr2 Cfp Pafah1b2 C3ar1 Rab7 Surf4 Rab9b Rab18 Ptpn6 Gyg Rab6a Gsn Alad Agl Psmc2 Hmox2 Psmd2 Hsp90aa1 Hk3 Pygl Gaa Psmc3 Pygb Tubb4b Anpep Fabp5 Fgr Cst3 Mlec Dynll1 Fcgr3 Idh1 Apaf1 Psap Ahsg Lcn2 Camp Cfd C3 Cap1 Trpm2 Tubb5 Rap1a Rap1b Dync1h1 Lamp2 Psma5 Aprt Rnase2b Ampd3 Pecam1 Vcl Psma2 Orm3 Impdh1 Qsox1 Dnajc3 Pglyrp1 Manba Iqgap1 Actr2 Man2b1 Timp2 Ctss Cd63 Ctsg Ctsb Ncstn Itgax Psmd1 Ctsd Arhgap9 Slc11a1 Psmd3 Psmd6 Psmd7 Cd44 Gpr84 Mmp8 Chit1 Gm2a Vcp Dnajc5 Ckap4 Slco4c1 Calm4 Aldh3b1 Scamp1 Krt1 Nfkb1 Pnp Cat Ptprj S100a11 Cdk13 Lrg1 Ano6 Lamp1 Fuca2 Rnase2a Fth1 Plekho2 Ftl1 Chil1 Rac1 Pycard Anxa2 Rab31 Hgsnat Tspan14 Bst2 Sell Ilf2 2310033P09Rik Rab10 Dsn1 Vapa Grn Lrmp Tnfrsf1b Rab24 Cxcr1 Vamp8 Glipr1 Fpr1 Atg7 H2-Q1 Psen1 Commd9 Tlr2 Serpinb3d Ptafr Cxcr2 Cxcl3 Dsg1a Plac8 Pkm Dsp Cmtm6 Tbc1d10c Rnaset2a Plau Prcp Tcirg1 Glb1 Pkp1 Vat1 Atp6v0a1 Golga7 Elane Lair1 Adam8 Atp6v1d Mmp25 Cd36 Hebp2 Snap23 9030624J02Rik Hp Erp44 Stk10 Prg2 Prg3 Ms4a3 Ghdc Ptges2 Tmbim1 Lta4h Oscar Ypel5 Nras Gca Prtn3 Epx Snap29 Pigr Qpct Nfam1 Cd177 Nit2 Galns Alox5 Acly Hexb Cd93 Ndufc2 Kcnab2 Tmem63a Nhlrc3 Atad3a Cd68 Tmem30a Pdap1 Serpinb6a Ptprn2 Fgl2 Commd3 Retn Cant1 Acpp Dnase1l1 Huwe1 Slpi Ormdl3 Aga Abca13 Lrrc7 Tnfaip6 Stom Dbnl Taf6l Frk Pdxk Serpinb1a Rab27a Serpinb10 Serpinb12 Lamtor1 Rap2c Syngr1 Rap2b Plaur Slc27a2 Cpped1 Lamtor2 Hvcn1 Flg2 Cstb Cd53 Ptx3 1600012H06Rik Olfm4 Siglece Asah1 Tmc6 Mospd2 Ist1 Psmb7 Itgal Psmb1 Mapk1 Ppia Cct2 Ostf1 Armc8 Ppbp Actr10 Nbeal2 Ubr4 Gla Actr1b Stk11ip Slc15a4 Crispld2 Gpi1 Dpp7 Degs1 Fcnb Cct8 Ppie Rhoa Apeh Naprt Cyb5r3 Eef2 Trappc1 Bst1 Sptan1 Cd59b Dgat1 Ttr Cracr2a Prss2 Mpo Ptprb Lpcat1 Ptprc Ticam2 Ctsz Serpina1d Serpina1a Dync1li1 Cd14 Dock2 Cab39 Hsp90ab1 Pld1 Ctsc Hbb-bt Vnn1 Fuca1 Cpne3 Npc2 Cpne1 Mgst1 Pa2g4 Copb1 Cd300a Hbb-bs Mif Unc13d Dok3 Gusb Hpse Aoc1 Lgals3 Mgam Creg1 Rab14 Adgre5 Padi2 Prdx4 Chrnb4 Tollip Mvp Mettl7a1 Adgrg3 Bin2 Faf2 Clec12a B4galt1 Kcmf1 Atp8a1 Clec4d Pgrmc1 Crisp1 Prdx6 Bri3 Jup Cotl1 Fcer1g Ddx3x Clec4b2 Sirpa Tyrobp Cand1 Sirpb1b Mcemp1 Dsc1 Tarm1 Gsdmd Cystm1 Arl8a Agpat2 Olr1 Stbd1 Mapk14 Cnn2 Enpp4 Atp11a Atp11b Cd47 TRANSCRIPTION FROM MITOCHONDRIAL PROMOTERS%REACTOME DATABASE ID RELEASE 59%75944 Transcription from mitochondrial promoters Polrmt Tfam Tfb2m Mterf1b METABOLISM%REACTOME%R-HSA-1430728.7 Metabolism 2410127L17Rik Ormdl2 Crym Akap5 Lss Qdpr Vapb Gstz1 Ppap2c Mvk Phykpl Ormdl1 Aass Ugcg Hal Mtf1 Il4i1 Srebf2 Hgd Aldh4a1 Pmvk Cbr1 Ido2 Fah Insig2 Nrf1 Ido1 Pipox Insig1 Thrap3 Gba2 Pdss1 Pdss2 Cerk Sqle H2-Ke6 Arntl Hmgcll1 Mogat1 Mogat2 Cptp Acot9 Esyt3 Acot7 Esyt1 Esyt2 Cbr4 Osbpl3 Osbpl9 Osbpl6 Osbpl7 Grhl1 Acat2 Nsdhl Osbpl2 Acot11 Acot12 Acot13 Msmo1 Cers4 Mcat Cers5 Cers6 Acer3 Acer1 Cers3 Fhl2 Cers2 Aacs Acer2 Cers1 Mbtps1 Coq6 Mbtps2 Coq5 Coq9 Olah Idi1 Ncoa3 Coq7 Coq3 Uqcrc2 Uqcrc1 Uqcrfs1 Etfa Coq10b Med1 Uqcrb Coq10a Trap1 Uqcrq Etfdh mt-Cytb Uqcr10 Cox14 Cox11 Med4 Cox16 Sco1 Med8 Med6 Cox18 Slc3a2 Kmo Tdo2 Acot2 Acot3 Acot4 Fdft1 Med9 Hnmt Afmid Acmsd Hdc Asrgl1 Ftcd Prodh Uroc1 Slc7a5 Hpd Aldh7a1 Haao Carns1 Ccbl1 Pah Pcbd1 Hykk Tat Gcdh Kynu Amdhd1 Aadat Slc25a21 Ccbl2 Alox12b Hsd17b7 Cdk19 Pla2g5 Ptgr2 Ptgr1 Pla2g4d Enpp7 Pla2g4e Sgpl1 Pla1a Dhcr24 Pla2g4f Sptssb Sptssa Ephx2 Eci1 Asah2 Fam120b Stard5 Fa2h Ch25h Pla2g2e Rgl1 Pla2g12a Slc2a5 Osbpl8 Gltp Gk2 Pla2g2d Pon2 Pla2g1b Clock Pla2g2f Pon1 Osbpl5 Degs2 Lpcat4 Acbd7 Lpcat3 Slc2a4 Acbd6 Acad12 Slc2a3 Pla2g4a Tnfrsf21 Pla2g10 Acad10 Pla2r1 Slc2a2 Acad11 Slc2a1 Pla2g16 Acaa2 Mboat1 Pnpla5 Osbpl10 Rpia Pgm1 Pgls Tkt Pgd Rpe Dera Taldo1 Hpgd Prkd3 Acsm3 Sptlc2 Omd Alox5ap Prelp Med13l Kera Smpd4 Ogn Smpd1 Slc16a3 Oxct1 Gna11 Slc16a1 Prkd1 Bsg Gnaq Slc16a8 G0s2 Gna15 Sptlc3 Sptlc1 Prkd2 Gna14 Med22 Nadk Hexa Slc19a2 Slc19a1 Bdh2 Bdh1 Slc25a19 Pank4 Med28 Med29 Mocs3 B3galnt1 Mocs2 Med21 Lrat Pank1 Med11 Parp6 Sgms2 Me1 Pank3 Pank2 Ltc4s Parp9 Med19 Decr2 Lmbrd1 Parp4 Sgms1 Flad1 Decr1 Ppap2b Ppargc1b Fdps Ppap2a Ankrd1 Ugt8a Ppargc1a Ptgds Ggps1 Ptges Sc5d B4galnt1 Abcd4 Gyk Sphk2 Cyp8b1 Faah Osbp Slc25a16 Acadl Fgf21 Hmgcs2 Fam213b Kdsr Tm7sf2 Plin2 Ppm1l Galc Dbi Lbr Scd1 Acsf2 Csnk1g2 Them5 Pon3 Scap Med18 Alox12 Dhcr7 Hsd11b1 Hsd11b2 Slc10a2 Slc10a1 Gpd2 Hmgcl Ebp Pex11a Npas2 Arv1 Acads Sgpp2 Sgpp1 Helz2 Cox4i1 Gls2 Cox8a Chst3 Med20 Dtymk mt-Co3 Nubp2 Chsy1 mt-Co2 Guca2b Chpf Scly Bgn Tph2 Dcn Med27 Guca2a Chsy3 Med26 Lyve1 Bcan Tph1 Chst15 Gcsh Cad Gale Galk1 Hpse2 Med23 Glrx Cspg4 Med24 Nubp1 Cspg5 Med25 Dhtkd1 Nme1 Cox7b Nme4 Hs6st1 Ak8 Hs6st3 Hs6st2 Ak7 Ak5 Lipt2 Chst13 Csgalnact1 Lipt1 Csgalnact2 Agxt Sgsh Ncan Havcr2 Amt Chst12 Vcan Inmt Apoe Chst7 Cacna1e Cacna1a Chst11 Ercc2 Lalba Chst14 Hao1 Ciao1 Gm21685 Rxra Lyrm4 Dctpp1 Carm1 Ak1 Ak2 Dhodh Mms19 B3galt6 Gucy2c Cox5a Tmem55b Gys1 Gyg Tbl1xr1 Tpo Alad Hmox1 Duox2 Blvrb Dio3 Iyd Blvra Hmox2 Dio2 Ccnc Tead3 Hsp90aa1 Tead1 Tead2 Sp1 Prkar2b Hmbs Fech Alas1 Alas2 Uros Ppox Cox15 Urod Cox10 Cpox Esrra Cygb Gchfr Prkg2 Pts Cox6a1 Gls Crebbp Idh1 Gpx2 Lypla1 Prkaca Zdhhc21 Ddah2 Ddah1 Spr Gch1 Cox6b1 Cox20 Slc5a2 Slc5a3 Acadvl Slc5a1 Slc5a9 Slc5a4a Srd5a2 Hsd3b1 Hsd3b6 Srd5a1 Brip1 Srd5a3 Ndufa4 Ak6 Tead4 Ppp1ca Mtmr4 Ncoa1 Surf1 Cd44 Duox1 Dio1 Ncoa6 Ncoa2 Prkaa2 Cdk8 Slc22a3 Rrm2b G6pdx Nr1h2 Atp5b Abcb1a Slc50a1 Taf9 G6pc Ep300 Abcg2 Txnrd1 Med31 Nr1d1 Tbl1x Med30 Ctgf Glb1 Mcee B3gnt3 B3gnt2 B3gnt7 B3gnt4 Prkag2 Abcb4 Med13 Med14 Med12 Med10 Chd9 Med16 Med17 Med15 Slc37a4 Abcc3 Rora Ncor1 Lrpprc Ncor2 mt-Co1 Smarcd3 Ppard Txn1 Ppara Pparg Yap1 Cox7a2l Slco1a4 Wwtr1 Slco1b2 Slc45a3 Slc5a10 Slc5a5 Stk11 Prkab2 Taco1 Gpi1 Acbd4 Ehhadh Hacl1 Acbd5 Nudt7 Acox3 Slc25a17 Agps Hao2 Mlycd Acoxl Nudt19 Crot Pecr Crat Phyh Oplah Ugdh Pik3c3 Cyp21a1 Mat2a Acat1 Nqo2 Bcat2 Cyp26c1 Acad8 Gsta3 Bbox1 Ephx1 Ivd Dpep1 Aldh6a1 Dpep2 Pik3r4 Bckdk Aldh3a1 Bcat1 Dpep3 Hibadh Cyp3a16 Auh Mat2b Aldh9a1 Gss Dbt Abhd10 Sult1a1 Cyp3a13 Ugt1a1 Abhd14b As3mt Cyp2a5 Marc1 Marc2 Tbxas1 Aip Hpgds Cyp4a32 Cyp11b1 Cyp4f39 Cyp11b2 Sult1b1 Cyp51 Cyp2s1 Ahr Cyp2j6 Tmlhe Ppm1k Bckdha Bckdhb Acadsb Hibch Ocrl Inpp5b Ugt1a6a Cyp4a12b Maob Gstm5 Gclm Gstm7 Sult2a1 Ahcy Aldh1b1 Cyp1a2 Cndp2 Cyp26b1 Gclc Sult1e1 Akr7a5 Ptgs1 Gstm2 Cyb5b Ggt6 Ggt7 Gstm4 Cyp1a1 Cyp2d22 Cyp2e1 Ugt2b38 Adh5 Arnt2 Ugt2b36 Adh7 Ugt2b34 Gstm1 Ggt5 Cyp17a1 Slc25a1 Slc35d1 Aldoc Aldob Cyp2w1 Aldoa Cyp2f2 Cyp2c65 Pfkfb4 Gbe1 Chac2 Chac1 Pcx Gys2 Cyp26a1 Eno2 Cyp2b10 Acy3 Eno3 Fmo1 Ugp2 Adh1 Fmo2 Tpi1 Adh4 Pgk2 Cyp1b1 Eno1 Fmo3 Pgk1 Pfkm Bpnt1 Pfkp Ugt1a5 Pfkl Ugt1a9 Gm10639 Fbp1 Nhlrc1 Acy1 Aldh2 Phkg1 Ugt1a2 Fbp2 Akr1a1 Bpgm Mat1a Pfkfb3 Ahrr Pfkfb2 Cyp4f40 Pgam1 Ugt3a2 Pgam2 Cyp2c50 Got2 Cyp2c55 Pgm2 Bphl Pfkfb1 Gck Esd Nup50 Tpr Ndc1 Nup214 Aaas Nup210 Nup188 Nup54 Nup35 Rrm2 Nupl2 Tyms Nup62 Dhfr Nup205 Tk2 Nup155 Nup88 Pom121 Agk Rae1 Nup93 Nup153 Hmmr Ran Snap25 Mri1 Adi1 Got1 Enoph1 Apip Dars Mtap Rars Eef1e1 Lars Aimp1 Iars Mars Aimp2 Eprs Qars Kars Ddc Th Dbh Pnmt Mmachc Gif Amn Mut Mtrr Cd320 Cubn Mmadhc Mmaa Tcn2 Mtr Vamp2 Stx1a G6pc2 G6pc3 Prkca Crls1 Psmd12 Psmd11 Plin3 Psmd14 Sepsecs Pstk Psmd13 Eefsec Psmd10 Ppa1 Ppa2 Secisbp2 Sars Ppp2r1b Shfm1 Itpr1 Pten Itpr3 Itpr2 Trib3 Psmc6 Far1 Hk1 Gapdhs Agl Ppp1r3c Psmc5 Phka1 Eno1b Slc25a10 Psmc2 Slc25a12 Psmd2 Prkacb Nos3 Nostrin Psmb9 Psmb8 Awat1 Far2 Hk2 Sphk1 Pygm Hk3 Pck2 Pygl Gnpda2 Adpgk Ppp2r5d Gnpda1 Nat2 Phkg2 Nat1 Slc25a13 Psmc1 Slc25a11 Psmc4 Gaa Psmc3 Pik3cb Phka2 Epm2a Pik3cd Nosip Mdh1 Phkb Pygb Fyn Alox8 Alox15 Gpx4 Slc27a1 Pik3ca Slc35b2 A2m Slc26a1 Slc26a2 Slc35b3 Papss2 Papss1 Pip5k1a Rap1a Psma5 Ippk Ip6k1 Ip6k2 Psma4 Ppp1cb Psma3 Psma6 Ipmk Psma2 Psma1 Pip5k1b Pip5k1c Tiam2 Psmd9 Man2c1 Man2b2 Iqgap1 Manba Man2b1 Pcsk6 Pcsk5 Them4 Psmd1 Psmd3 Psmd4 Psmd6 Psmd5 Pik3r3 Psmd7 Pik3r1 Smpd2 Psmd8 Pik3r2 Hdac3 Chit1 Gm2a Ppp2r1a Aldh3b1 Ecsit Osbpl1a Vapa Glipr1 Vkorc1 Vkorc1l1 Ubiad1 Ptgs2 Alox5 Hexb Ormdl3 Rtel1 Gla Degs1 Mccc2 Mthfr Nfyb Mccc1 Akr1c6 Nfyc Btd Ldlr Tpk1 Lrp1 Slc52a3 Slc52a2 Slc23a1 Slc25a32 Shmt2 Bco1 Shmt1 Nfya Asns Bco2 Slc23a2 Akr1c18 Apoa4 Cyp2r1 Nnmt Mthfsl Akr1c21 Apoa2 Apom Mthfd2 Fasn Mthfd1 Aldh1l2 Naprt Rdh11 Ppcs Rfk Tymp Pdzd11 Cyb5r3 Apoa1bp Ins2 Upp2 Pnlip Nampt Upp1 Aldh1l1 Agxt2 Nt5m Bst1 Sec24a Sec24b Sec24d Sec24c Nt5c1a Nt5e Nt5c Upb1 Dpyd Dpys Clps Lgmn Hlcs Parp8 Slc5a8 Slc5a6 Coasy Apoc2 Apoc3 Cyp27b1 Qprt Gpihbp1 Nmrk2 Thtpa Ptgis Ttr Lpl Acacb Slc46a1 Nmrk1 St3gal4 Mocos Pcca Acaca Ctrb1 Mthfd2l Acp5 Pccb Prss2 Nadsyn1 Mmab Ctrc Cyb5a Rbp2 Cyp24a1 Rbp1 Folr2 Enpp3 Parp14 Akr1b10 Parp16 Rbp4 Enpp1 Cd38 Enpp2 Parp10 Mthfd1l Nmnat2 Nmnat1 Nmnat3 Abcc1 Gsto1 Gsto2 Gphn Aasdhppt Nudt12 Gc Ppcdc Vnn3 Lrp2 Plb1 Lrp12 Vnn1 Lrp10 Slc22a13 Rpl39 Ces1d Tpmt Rplp1 Cyp2u1 Sar1b Aadac Sult4a1 Mgst1 Ggt1 Mgst2 Mgst3 Rpl7 Cyp3a57 Rps21 Gstt2 Rplp2 Gstt1 Cyp4f18 Sec23a Cmbl Cyp4f17 Rps25 Ugt2b1 Rpl4 Cga Gstk1 Lhb Cyp4f15 Rps26 Arnt Rps27l Acss1 Cyp4b1 Rpl18a Cbr3 Rpl34 Gusb Rpl32 Ces2h Hpse Aoc1 Arf1 Aoc2 Aoc3 Arf3 Rpl26 Por Rpl24 Acss2 Cyp4f14 Rps9 Ugt2a3 Ugt2a2 Rps7 Ugt2a1 Rps5 B4galt3 B4galt1 B4galt5 B4galt4 B4galt6 B4galt2 Rpsa Rpl37 Rps4x Slc9a1 Rpl22 Rpl10l Rpl23 Rpl39l Rpl13a Rpl22l1 Rps15a Rpl11 Rpl17 Rps3 Rpl19 Rpl18 Prps1l1 Rps16 Prps2 Rps14 Rps19 Rps18 Rps11 Slc35d2 Rps10 Prps1 Agrn Lum Inpp5a Inpp1 Isyna1 Impa1 Impa2 Echs1 Hadhb Acadm Hadha Hadh Ap2m1 Csnk2a2 Ap2a1 Ap2a2 Dnm2 Ap2s1 Clta Ap2b1 Csnk2b Cltc Cyp4v3 Hsd17b1 Kpnb1 Tk1 Hdhd1a Uck1 Uck2 Cda Cyb5r1 Pycr2 Pycr1 Oat Glud1 Pycrl Aspg Psat1 Naalad2 Phgdh Serinc5 Serinc4 Aspa Serinc3 Psph Gpt Serinc1 Serinc2 Gadl1 Glul Comt Maoa Plch2 Gngt1 Gng7 Plch1 Itpkb Itpkc Gng4 Plcd4 Gcg Plcd1 Ppip5k2 Gngt2 Glp1r Ppip5k1 Nudt10 Plcz1 Minpp1 Gng10 Plcd3 Gcgr Ip6k3 Nudt11 Sord Akr1b3 Fabp12 Fabp7 Plin1 Fabp6 Fabp5 Fabp4 Fabp3 Fabp2 Fabp1 Fabp9 Cav1 Lipe Abhd5 Gng11 Gng13 Gng12 Gnb2 Gnb1 Gnb3 Cpt1b Gnb5 Slc25a20 Cpt2 Gnb4 Cpt1a Mid1ip1 Thrsp Gng8 Gng3 Gng2 Aldh1a1 Psap Alb Adss Gmpr Aprt Ppat Ada Pfas Ampd2 Ampd3 Dguok Impdh1 Gmpr2 Lhpp Gmps Fmod Nudt4 Nudt3 Plce1 Itpka Ampd1 Hprt Atic Pnp Cat Paics Gpx1 Dck Adk Adssl1 Adsl Gart Gda Xdh Acsm1 Wasl Mlxipl Apoa1 Adipor2 Apob Adipor1 Adipoq Cd36 Mttp Apoc1 Apoc4 P4hb Glyctk Khk Tkfc Adcy7 Ptges2 Adcy6 Adcy5 Lta4h Adcy4 Adcy3 Adcy2 Prkar2a Adcy1 Adcy9 Psmf1 Adcy8 Acly Psme4 Psme3 Fdx1 Fdx1l Star Stard4 Cyp11a1 Stard3nl Stard3 Fdxr Furin Prkar1a Prkar1b Ppp2cb Ppp2ca Psma7 Plcg1 Asah1 Psmb5 Stxbp1 Psmb4 Ubc Psmb7 Psmb6 Psmb2 Psmb3 Psmb1 Akt1 Apoa5 Lipc Pip4k2b Pip4k2a Cacnb2 Pip4k2c Cacnb3 Cacna2d2 Cacna1c Cacna1d Psme2 Psme1 Kcnj11 Abcc8 Psmb10 Ahcyl1 Angptl3 Psmb11 Creb3l3 Angptl4 Ldlrap1 Gm6484 Acox2 Hsd17b4 Cyp7a1 Cyp7b1 Baat Acot8 Abcb11 Nr1h4 Ppt2 Hsd17b3 Hacd2 Hacd3 Hacd1 Ppt1 Acsl3 Acsf3 Hsd17b12 Hacd4 Acsbg1 Acsl6 Acsl5 Acsl4 Elovl7 Acsbg2 Slc27a3 Acsl1 Elovl6 Tecr Tecrl Mapkapk2 Elovl1 Elovl5 Elovl4 Elovl3 Cyb5rl Elovl2 Aqp1 Hba-a1 Slc4a1 Car4 Car2 Cyb5r2 Car1 Cyb5r4 Rab5a Itpk1 Sin3a Hbb-bt Npc1 Npc2 Hdlbp Soat1 Soat2 Lmf2 Lmf1 Hsd17b14 Hbb-bs Cyp19a1 Hsd17b11 Hsd17b2 Akr1b8 Reln Lipk Abca1 Fitm1 Fitm2 Lipa Apof Ces3b Pnliprp1 Abcg1 Zdhhc8 Lsr Lipf Lipg Liph Lipn Cidec Cidea Abcg5 Mylip Dab1 Abcg8 Pnliprp2 Nr1h3 Hsd17b13 Pcsk9 Apobr Lcat Nceh1 Hilpda Vldlr Cel Gckr Has3 Abcc5 Has1 Cemip Has2 Trmt112 Arl2 Oaz3 Oaz2 Arg1 Paox Odc1 Srm Ckmt2 Arsg Pold1 Ckmt1 Arg2 N6amt1 Gamt Arsi Arsb Ass1 Arsa Nags Oaz1 Nmral1 Slc6a8 Nqo1 Gatm Sat1 Agmat Arsk Arsj Azin2 Slc25a2 Azin1 Slc6a12 Gba Cps1 Sms Otc Ckm Asl Ckb Slc6a7 Slc6a11 Slc25a15 Ctsa Slc22a2 Rhag Slc22a1 Slc44a3 Slc44a4 Slc44a5 Slc44a1 Slc44a2 Fxn Mvd Abcd1 Fads1 Acaa1a Car3 Car7 Car12 Car6 Rapgef4 Rapgef3 Kcnb1 Kcns3 Kcng2 Kcnc2 Fads2 Scp2 Guk1 Pck1 Adal Nt5c2 Car13 Car5b Car14 Car5a Car9 Bhmt2 Mt2 Mt4 Mt1 Mt3 Dld Ogdh Idh3g Hsd17b10 Sdhd Sdha Mdh2 Sdhc Suclg2 Suclg1 Sdhb Idh2 Idh3b Idh3a Fh1 Sucla2 Nnt Dlst Aco2 Cs Gns Neu1 Neu3 Neu2 Slc25a4 Cyc1 Coq2 Pomc Etfb Chrm3 Pik3r6 Pik3r5 Atp5a1 Gnai2 Gnai1 Plcg2 Sh3kbp1 Slc25a5 Ldhc Pdhb Dlat Adhfe1 Pdpr Glo1 Ldha Ldhb Pdp2 Pdp1 Pdhx Gcat Pdha1 D2hgdh B4gat1 Ldhal6b L2hgdh Pdk1 Pdk2 Mpc1 Mpc2 Pdk3 Pdk4 Sumf2 Sumf1 St3gal1 St3gal2 St3gal6 Acsm2 Glyatl3 Glyat Hyal2 Acsm5 Nup85 Nup160 Rps27 Mlx Ndor1 Ndst2 Gnmt Arl2bp Naglu Lclat1 Tyrp1 B4galt7 Ciapin1 Aanat Dctd Pla2g6 Dse Taz Hyal1 Hyal3 Acsm4 Rrm1 Dcxr Ppp1cc Nup107 Ffar1 Hs3st2 Ctps Narfl Entpd2 Entpd1 Entpd4 Entpd3 Entpd6 Nup37 Adprm Agt B3gat3 B3gat2 Nup43 Nup133 B3gat1 Hs3st5 Hs3st6 Hs3st4 Hs3st1 Fam96b Oca2 Cryl1 Slc25a37 Chst2 Chst5 Hs2st1 Chst1 Entpd8 Entpd5 Glce Entpd7 Xylt2 Gldc Slc25a28 Mgll Xylt1 Dsel Tyr Ext2 Ext1 Chp1 Ust Nudt5 Umps Ndst3 Ctps2 Ndst1 Ndst4 Ids Chia1 Galt Slc45a2 Idua Hs3st3a1 Nudt15 Nudt13 Xylb Ranbp2 Itpa Dct Marcks Lias Hs3st3b1 Syt5 Grhpr Nudt16 Ddo Dao Cmpk1 Ndufs5 Ndufs4 Ndufa13 Ndufs2 Ndufb11 Ndufb10 Ndufs7 Ndufs8 Ndufa11 Ndufs1 Ndufa10 Ndufa12 Ndufb2 Acad9 Ndufc2 Ndufc1 Ndufb4 Ndufb3 Ndufb6 Ndufb5 mt-Nd2 mt-Nd1 Timmdc1 Nubpl mt-Nd6 mt-Nd5 mt-Nd4 mt-Nd3 Ndufaf1 Slc25a27 Ndufaf2 Ndufaf3 Ndufa1 Ndufa2 Ndufa3 Ndufa5 Ndufaf4 Ndufb9 Ndufb7 Yjefn3 Ndufb8 Tmem126b Slc25a14 Ucp1 Ndufv3 Ucp3 Ndufv1 Ucp2 Ndufv2 Slc27a5 Cyp46a1 Pdxk Cyp27a1 Pnpo Akr1d1 Amacr Aox1 Hsd3b7 Cyp39a1 Ndufab1 Ndufa6 Ndufa7 Ndufaf5 Ndufaf6 Ndufa8 Slc27a2 Ndufa9 Ndufaf7 Plcb1 Plcb2 Atp5g3 Atp5k Adra2a Atp5j mt-Atp6 Adra2c Stab2 Smpd3 Atp5s Atp5d Atp5j2 Atp5c1 Atp5f1 Plcb4 Plcb3 Pik3cg Tshb Tst Ado Cdo1 Cth Cbs Ethe1 Suox Sqrdl Csad Mfsd2a Dgat2 Chkb Gde1 Pi4kb Pld3 Etnppl Bmx Cept1 Dgat2l6 Mtmr2 Chat Mtmr1 Dgat1 Chka Mtmr3 Tnfaip8l2 Mtmr7 Mtmr6 Tnfaip8 Inppl1 Tnfaip8l1 Gnpat Tnfaip8l3 Inpp5k Pgs1 Pitpnm1 Abhd4 Vac14 Pcyt2 Abhd3 Lpcat1 Plekha5 Plekha6 Lpgat1 Plekha8 Bhmt Synj2 Plekha1 Plekha2 Hsp90ab1 Pld2 Pi4ka Pld1 Gpd1l Synj1 Pld4 Gpcpd1 Plekha3 Cpne3 Acp6 Pemt Cpne1 Gpd1 Pi4k2b Cpne7 Cpne6 Pik3c2b Pik3c2a Mtm1 Pik3c2g Enpp6 Mboat2 Mboat7 Chdh Pnpla2 Cds2 Agpat6 Agpat5 Etnk1 Inpp4b Pnpla8 Inpp4a Tpte Pikfyve Amy1 Fig4 Mgam Phospho1 Lct Pnpla3 Sis Amy2a3 Pnpla6 Treh Awat2 Alpi Rab14 Gpam Cdipt Lpcat2 Lpin2 Plbd1 Ept1 Pitpnb Inpp5d Pitpnm2 Stard10 Pitpnm3 Pi4k2a Hrasls5 Inpp5f Inpp5e Ptdss2 Ptdss1 Hrasls Rufy1 Ddhd1 Sacm1l Ptpn13 Ache Lpin3 Pla2g3 Lpin1 Stard7 Dmgdh Mtmr14 Pcyt1a Pcyt1b Sdc3 Gdpd1 Sdc4 Sardh Gpc6 Pctp Sdc2 Gdpd5 Gpc3 Rab4a Sdc1 Cds1 Bche Gpc5 Gpc2 Tmem86b Pla2g4c Agpat3 Gpc4 Agpat4 Agpat1 Agpat2 Pisd Pnpla7 Agpat9 Chpt1 Hspg2 Gdpd3 Gpc1 Gpat2 AMINO ACID CONJUGATION%REACTOME%R-HSA-156587.1 Amino Acid conjugation Acsm2 Glyatl3 Acsm1 Glyat Acsm5 Acsm4 DEFECTIVE TRP MAY CONFER SUSCEPTIBILITY TOWARDS THYROID PAPILLARY CARCINOMA (TPC)%REACTOME DATABASE ID RELEASE 59%5619107 Defective TRP may confer susceptibility towards thyroid papillary carcinoma (TPC) Gckr Gck WNT LIGAND BIOGENESIS AND TRAFFICKING%REACTOME%R-HSA-3238698.1 WNT ligand biogenesis and trafficking Wnt11 Wnt10a Porcn Wnt3 Wnt10b Wnt6 Wnt4 Wnt9b Wnt9a Vps26a Wls Tmed5 Wnt7a Snx3 Wnt2b Wnt7b Wnt16 Wnt3a Wnt8a Wnt8b Wnt5b Vps29 Wnt5a Wnt1 Vps35 Wnt2 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS%REACTOME%R-HSA-1606322.1 ZBP1(DAI) mediated induction of type I IFNs Ripk3 Chuk Tbk1 App Ticam1 Ripk1 Nlrp4e Ikbkb Ager Dtx4 Tlr3 Ikbkg Rela Irf3 Nfkb2 Nfkbia Nfkb1 Nfkbib Saa3 Myd88 Dhx9 S100b Zbp1 PINK PARKIN MEDIATED MITOPHAGY%REACTOME%R-HSA-5205685.1 Pink Parkin Mediated Mitophagy Vdac1 Atg5 Sqstm1 Tomm6 Mfn2 Ubc Tomm7 Park2 Tomm22 Mterf3 Atg12 Pink1 Tomm70a Map1lc3a Tomm40 Map1lc3b Mfn1 HYDROLYSIS OF LPC%REACTOME%R-HSA-1483115.2 Hydrolysis of LPC Pla2g4d Plbd1 Pla2g4e Pla2g4f Pla2g4c Pla2g4a Gpcpd1 UREA CYCLE%REACTOME DATABASE ID RELEASE 59%70635 Urea cycle Slc25a15 Arg1 Slc25a2 Cps1 Arg2 Otc Ass1 Asl Nags Nmral1 MEMBRANE TRAFFICKING%REACTOME%R-HSA-199991.4 Membrane Trafficking Myo6 Dvl2 Arpc5 Arpc4 Klc3 Klc2 Klc4 Racgap1 Ocrl Bloc1s4 Tbc1d8b Bloc1s3 Ap2m1 Bloc1s6 Vps25 Hspa8 Necap1 Acbd3 Hip1r Picalm Dtnbp1 Cpd Ap2a1 Pum1 Gak Gdi2 Gdi1 Ap2a2 Sh3gl2 Snf8 Dnm2 Vps36 Trip10 Klc1 Ap2s1 Dnm1 Cttn Arpc1a Als2cl Sbf1 Cops7b Sbf2 Cops7a Dennd5a Dennd5b Mon1a Mon1b Als2 Clta Ulk1 Ap2b1 Ankrd27 Dennd4a Dennd4b Cops8 Clint1 Tpd52l1 Kif4 Cltc Cops6 Sort1 Cops2 Snx2 Cops4 Ap3s1 Cops5 Sh3d19 Dnm3 Yipf6 Cops3 Snapin Fzd4 Itsn1 Snx9 Snx5 Ap3b1 Slc2a4 Pla2g4a Slc2a8 Optn Tbc1d24 Adrb2 Cux1 Ap4b1 Clvs1 Ap1g2 Ap1s2 Ap1b1 Ap1s1 Bloc1s1 Ap1g1 Dnajc6 Ap1s3 Ap4e1 Rab3a Vamp7 Syt1 Ap4s1 Vamp2 Clvs2 Txndc5 Ap4m1 Dnase2a Ap1m2 Gns Ap1m1 Rab33a Tsc2 Rab5c Rab5b Arrb2 Egfr Arrb1 Adrbk1 Rala Rab35 Agtr1a Cltb Golga4 Golga1 Stx18 Scoc Naa38 Rab3gap1 Naa30 Naa35 Arfip2 Rabepk Tmf1 Arl1 M6pr Rab9 Plin3 Igf2r Gcc1 Gcc2 Rab11b Chm Bicd2 Bicd1 Usp6nl Rab43 Pafah1b3 Pafah1b2 Vamp4 Rhobtb3 Rab39b Ywhab Chml Rab8b Rab7 Vps54 Cd3d Surf4 Rab9b Arfrp1 Avp Galnt1 Galnt2 Rab18 Avpr2 Cd4 Rint1 Gja3 Bnip1 Gja5 Rab6b Rab6a Gjb6 Vps52 Gjb5 Vps51 Cd3g Gja4 Use1 Gjc2 Vps53 Gapvd1 Pafah1b1 Egf Trappc11 Dennd6b Trappc12 Trappc13 Rab3il1 Dennd1b Dennd6a Rinl Dennd3 Ywhag Rabgef1 Stxbp3 Dennd1c Rab3ip Dennd4c Trappc8 Hps1 Hps4 Rab8a Chrm2 Rin2 Rin3 Dennd2a Rin1 St5 Dennd1a Dennd2d Dennd2c Myo1c Rab11a Myh2 Csnk1d Dynll1 Sh3kbp1 Gjb1 Gjb2 Dync1i2 Dctn2 Dctn3 Ywhaz Ywhah Sfn Rab27b Cftr Dync1h1 Pip5k1c Actr2 Actr3 Kif5a Kif5b Nedd8 Arpc3 Arpc2 Rhoq Adrbk2 Zw10 Prkaa2 Ywhae Slc18a3 Gjd2 Pla2g6 Arf6 Fth1 Rab38 App Ftl1 Rac1 Rab32 Rab31 Rab12 Rab13 Wasl Rab10 Rab21 Wnt5a Cenpe Apob Kif2c Vamp8 Kif2b Vamp3 Kif18a Stx4a Tsc1 Kif2a Tjp1 Gga2 Tbc1d10c Tfrc Gga3 Trf Snap23 Gja10 Gjc1 Eps15l1 Epn1 Gga1 Prkag2 Prkag1 Prkag3 Rab36 Snap29 Rgp1 Rab30 Rab33b Trip11 Stx16 Rab39 Myh4 Myh7 Myh6 Myh8 Aspscr1 Dab2 Necap2 Gpr21 C2cd5 Snap91 Syt11 Tbc1d10a Tbc1d10b Hip1 Myh1 Myh3 Syt9 Snx18 Rabgap1 Reps1 Sgip1 Myo5a Fcho2 Fcho1 Rab27a Fnbp1l Syt2 Reps2 Ston2 Exoc3 Exoc4 Akt2 Akt3 Exoc1 Exoc5 Exoc6 Exoc8 Exoc7 Exoc2 Ubc Prkab1 Lnpep Map1lc3b Akt1 Tacr1 Prkab2 Gjd3 Gjd4 Gja1 Gjb4 Gjb3 Gja8 Ldlrap1 Ldlr Trappc2 Tgfa Trappc3 Ins2 Mcfd2 Trappc1 Rab1 F5 Preb Copa F8 Sec24a Sec24b Sptan1 Sec13 Tmed3 Sec24d Scfd1 Gria1 Sec24c Man2a1 Sh3gl1 Stam Hgs Arcn1 Tfg Ykt6 Stam2 Cd59b Eps15 Tbc1d15 Cog6 Chmp5 Tbc1d17 Lman2l Chmp7 D130043K22Rik Cog3 Chmp6 Sytl1 Cog4 Chmp3 Vps37d Tbc1d25 Cog2 Tbc1d14 Vps37c Sec31a Tbc1d13 Vps37b Tbc1d16 Cog1 Ctage5 Rab5a Myh15 Tonsl Gorasp1 Gabarapl2 Vps4b Kif3c Nsf Tor1b Vps4a Tor1a Trappc6a Vta1 Kif3b Myh13 Kif3a Chmp2a Pacsin3 Trappc6b Chmp4c Pacsin2 Chmp4b Pacsin1 Tmed9 Man1c1 Rabep1 Kif18b Ralgapb Bet1l Gabarap Gbf1 Epn2 Ankrd28 Fnbp1 Cbl Scarb2 Man1a Syt8 Trappc9 Aak1 Agfg1 Napb Vps37a Tbc1d7 Napg Ubqln2 Kifc5b Ubqln1 Kifc2 Tbc1d1 Napa Bin1 Trappc5 Tbc1d4 Spta1 Tbc1d2 Trappc4 Sptbn4 Dctn5 Dctn6 Cyth2 Kif16b Ctsz Kif26a Golim4 Dctn1 Serpina1d Itsn2 Col7a1 Amph Lman1l Cyth1 Dctn4 Areg Vti1a Stx6 Serpina1a Vps45 Golga5 Dync1li2 Kif26b Cyth4 Folr1 Cyth3 Dync1li1 Man1a2 Kif13b Alppl2 Ric1 Rab1b Kif20b Ppp6r1 Ppp6r3 Arf5 Cnih1 Kif20a Tsg101 Kdelr2 Synj2 Kdelr3 Uso1 Kifap3 Bet1 Stx17 Cnih3 Kif22 Ctsc Lrp2 Cnih2 Kif27 Synj1 Cog7 Tmem115 Kif23 Cog8 Kif9 Arfgap3 Arfgap1 Arfgap2 Sar1b Kif12 Golgb1 Kif15 Copb2 Stx5a Kif19a Kif6 Kif1c Copb1 Pik3c2a Kif21a Ppp6c Kif21b Copz1 Ank1 Ank3 Kif1b Sec23a Kif1a Copz2 Trappc10 Sec23ip Copg1 Gosr1 Golga2 Dynll2 Gosr2 Arf1 Kdelr1 Arf3 Arf4 Kif11 Dync1i1 Sptbn2 Trappc2l Sptbn1 Rab14 Tbc1d20 Cope Sec16b Sec22a Lman1 Sec22b Sptb Lman2 Sec16a Sec22c Rab4a Agpat3 CTLA4 INHIBITORY SIGNALING%REACTOME DATABASE ID RELEASE 59%389513 CTLA4 inhibitory signaling Fyn Ppp2cb Ppp2r1b Ppp2ca Akt2 Akt3 Ppp2r1a Ppp2r5b Cd80 Yes1 Lyn Ppp2r5e Pdpk1 Lck Ppp2r5c Ppp2r5d Ppp2r5a Ctla4 Ptpn11 Akt1 Cd86 SEPARATION OF SISTER CHROMATIDS%REACTOME DATABASE ID RELEASE 59%2467813 Separation of Sister Chromatids Zw10 Ska1 Nup85 Pmf1 Nup160 Spc25 Nudc Rps27 Ppp2r1a Spc24 Xpo1 Clasp2 Itgb3bp Nuf2 Cenpf Ppp1cc Cenpq Cenpp Ahctf1 Cenpm Cenpl Cenpo Clip1 Cenpn Aurkb Zwilch Cdca8 Cenpt Sec13 Apitd1 Stag2 Sgol2b Ercc6l Stag1 Dsn1 Nup107 Mad1l1 Pttg1 Smc1a Rad21 Cenph Cenpi Cenpe Cenpk Kif2c Taok1 Birc5 Kif2b Kif18a Bub1b Zwint Nup37 Incenp Wapal Psmd12 Nup43 Nup133 Psmd11 Rcc2 Nsl1 Kif2a Ndel1 Spdl1 Psmd14 Ndc80 Kntc1 Psmd13 Bub3 Psmd10 Cdca5 Bub1 Cenpu Mad2l1 Casc5 Smc3 Cenpa Espl1 Cenpc1 Cdc23 Ppp2r1b Ube2d1 Cdc27 Cdc16 Cdc20 Ube2c Anapc16 Ube2e1 Anapc7 Anapc4 Shfm1 Anapc5 Anapc1 Anapc2 Sgol1 Pds5a Ranbp2 Mis12 Pds5b Pafah1b1 Psmc6 Psmc5 Psmc2 Psmd2 Psmb9 Psmf1 Psmb8 B9d2 Psme4 Ppp2r5e Ppp2r5c Ppp2r5d Ppp2r5a Psmc1 Psmc4 Psmc3 Psme3 Anapc15 Anapc11 Anapc10 Clasp1 Ppp2r5b Mapre1 Ppp2cb Ckap5 Ppp2ca Plk1 Psma7 Psma5 Psmb5 Psmb4 Ubc Psma4 Psma3 Psmb7 Psma6 Psmb6 Psmb2 Psmb3 Psma2 Psmb1 Psma1 Psmd9 Psmd1 Psme2 Psme1 Psmd3 Psmd4 Psmb10 Psmd6 Psmd5 Psmd7 Psmb11 Psmd8 GROWTH HORMONE RECEPTOR SIGNALING%REACTOME%R-HSA-982772.1 Growth hormone receptor signaling Ptpn1 Jak2 Stat5b Prl Stat5a Stat3 Socs2 Lyn Irs2 Socs3 Socs1 Irs1 Ptpn6 Adam17 Mapk3 Ghr Mapk1 Cish Prlr PERK REGULATES GENE EXPRESSION%REACTOME%R-HSA-381042.1 PERK regulates gene expression Ddit3 Nfyb Herpud1 Eif2s1 Nfyc Parn Atf6 Eif2ak3 Igfbp1 Atf3 Atf4 Hspa5 Nfya Asns Exosc9 Exosc8 Exosc7 Exosc5 Exosc4 Ccl12 Dcp2 Dis3 Exosc3 Exosc1 Exosc2 RNA POLYMERASE I TRANSCRIPTION%REACTOME%R-HSA-73864.1 RNA Polymerase I Transcription Mbd2 Ercc6 Hist2h3c1 Polr1a Znrd1 Polr1e Hdac1 Rbbp4 Chd3 Chd4 H2afj H2afb2 Polr2f Polr2e Polr2h Hdac2 Tbp Mnat1 Ubtf Polr1b Mbd3 Polr2k Ptrf Hist2h2be Hist3h2ba Polr1d Cbx3 Polr1c Mta1 Hist2h2ac Ttf1 Gtf2h1 Kat2b Kat2a H3f3b Mta3 H3f3a Gtf2h2 Hist1h2bg Gtf2h5 Hist1h2bh Gtf2h4 Cd3eap Hist1h2bp Hist1h2bm Hist1h2bj Rbbp7 Hist1h2bb Gtf2h3 Ercc3 Mta2 Taf1d H2afz Taf1c H2afx Taf1b Mapk3 Taf1a Ercc2 Hist2h2aa1 Gatad2a Rrn3 Gatad2b Hist1h3d Ehmt2 Hist1h2ak Ccnh Hist1h2ag Cdk7 Hist1h2ah ELONGATION ARREST AND RECOVERY%REACTOME%R-HSA-112387.2 Elongation arrest and recovery Paf1 Cdk9 Eaf1 Ctr9 Cdc73 Supt6 Polr2i Polr2f Polr2j Polr2e Nelfa Polr2h Nelfb Ell Polr2c Rtf1 Polr2d Supt4a Polr2b Tcea1 Tceb1 Iws1 Mllt1 Tceb3 Supt16 Aff4 Mllt3 Polr2k Polr2g Ccnt1 Ctdp1 Ssrp1 Ccnk Leo1 Polr2a Wdr61 Nelfe Supt5 Nelfcd Gtf2f1 Ccnt2 Gtf2f2 ERKS ARE INACTIVATED%REACTOME%R-HSA-202670.2 ERKs are inactivated Dusp3 Ppp2r1b Ppp2cb Mapk7 Dusp7 Dusp6 Ppp2ca Ppp2r1a Ppp2r5d Mapk3 Vrk3 Mapk1 Dusp4 SYNTHESIS OF (16-20)-HYDROXYEICOSATETRAENOIC ACIDS (HETE)%REACTOME DATABASE ID RELEASE 59%2142816 Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) Cyp4f15 Cyp2u1 Cyp2c65 Cyp1a1 Cyp1a2 Cyp4a32 Cyp2c50 Cyp1b1 TRANSCRIPTIONAL REGULATION BY TP53%REACTOME%R-HSA-3700989.5 Transcriptional Regulation by TP53 Perp Nuak1 Prkaa2 Cdk9 Ppp2r1a Trp53inp1 Ywhae Rffl Trex1 Rfc5 Rrm2b Taf1 Taf2 Rfc3 G6pdx Cdk12 Ddit4 Cdk13 Rfc2 Rnf34 Prkaa1 Taf4b Taf7 Rfc4 Taf4a Taf5 Taf6 Taf3 Ddb2 Hdac2 Nbn Jun Dna2 Npm1 Aurkb Slmo1 Taf9 Aurka Ccnt1 Rpa2 Rpa1 Atm Rqcd1 Ep300 Fancc Rpa3 Fanci Rad17 Ccnt2 Txnrd1 Prelid1 Birc5 Taf13 Taf11 Csnk2a2 Pml Arid3a Rbbp8 Gadd45a Tsc1 Rbbp7 Cox14 Cox11 Ccng1 Trp73 Cox16 Sco1 Taf12 Cox18 Csnk2b Prkag2 Prkag1 Prkag3 Cnot4 Cnot7 Cnot6 Cnot1 Cnot3 Brd7 Ppp1r13b Pcna Cnot2 Cnot8 Msh2 Rbl2 Rbl1 Ppp1r13l Bax Cdk2 Ndrg1 E2f4 E2f1 Rad50 Ccna1 Rbbp4 Chd3 Chd4 Ccna2 Bnip3l Tfdp2 Ttc5 Tfdp1 Lrpprc Cradd Rabggta Mbd3 Rabggtb Steap3 Ssrp1 mt-Co1 Usp7 Lamtor1 Top3a L3mbtl1 Gtf2h1 Gtf2h2 Ppp2cb Gtf2h5 Lamtor2 Gtf2h4 Txn1 Ppp2ca Lamtor5 Akt2 Akt3 Topbp1 Cox7a2l Lamtor4 Gtf2h3 Rad9a Aifm2 Ubc Rad9b Pcbp4 Cdkn2a Prdm1 Prkab1 Akt1 Zfp385a Stk11 Pip4k2b Pip4k2a Trp53 Prkab2 Pip4k2c Tcea1 Tceb1 Tceb3 Supt16 Taco1 Rictor Ehmt2 Rad51d Gpi1 Cdk7 Daxx Ehmt1 Mov10 Trp53rkb Tsc2 Brpf3 Mlst8 Ccne1 Mdm4 Brpf1 Ing5 Mtor Ccne2 Hdac1 Cox4i1 Ing2 Igfbp3 Nlrc4 Gls2 Bid Polr2i Polr2j Nelfa Rptor Nelfb Mnat1 Polr2c Map2k6 Polr2d Atrip Supt4a Polr2b Cnot11 Bcl2l14 Bard1 Polr2g Cnot10 Ctdp1 Chek2 Mre11a Polr2a Nelfe Supt5 Banp Nelfcd Gtf2f1 Cox8a Gtf2f2 Fas mt-Co3 mt-Co2 E2f7 Cnot6l Cdkn1a Tnfrsf10b Tpx2 Plk3 Rragd Rragb Rragc Rraga Ercc3 Cox7b Plk2 Rad1 Setd8 Chm Fancd2 Cdk5r1 Ercc2 Ppp2r1b Ywhab Hipk1 Ago2 Ago1 Tnrc6c Hipk2 Kat5 Gatad2a Tnrc6b Carm1 Gatad2b Tnrc6a Ago4 Ago3 Cox5a Mdm2 Pten Tmem55b Pou4f1 Pou4f2 Casp6 Casp1 Casp2 Meaf6 Cdk5 Trp53bp2 Pidd1 Kat6a Prdx2 Prdx1 Ywhag Mapkapk5 Bcl6 Mapkap1 Ppp2r5c Cdk1 Pin1 Tnks1bp1 Triap1 Polr2f Smyd2 Polr2e Polr2h Tbp Ell Phf20 Trp63 Taf9b Cox6a1 Gls Polr2k Atf2 Crebbp Gpx2 Cdkn1b Apaf1 Fos Mlh1 Rgcc Prr5 Cox6b1 Cox20 Chek1 Ywhaz Cdc25c Ywhah Tmem219 Sfn Btg2 Sgk1 Cenpj Rsph10b Dyrk2 Mta2 Blm Usp2 Hus1 Prmt5 Mdc1 Prmt1 Exo1 Brip1 Ndufa4 Pms2 Tigar Ak6 Wrn Jmy Mapk11 Brca1 Sesn2 Mapk14 Ccnh Pdpk1 Sesn3 Ccnk Surf1 PTK6 PROMOTES HIF1A STABILIZATION%REACTOME DATABASE ID RELEASE 59%8857538 PTK6 promotes HIF1A stabilization Gpnmb Egfr Hbegf Lrrk2 Hif1a Ptk6 ZINC EFFLUX AND COMPARTMENTALIZATION BY THE SLC30 FAMILY%REACTOME DATABASE ID RELEASE 59%435368 Zinc efflux and compartmentalization by the SLC30 family Slc30a5 Slc30a8 Slc30a6 Slc30a7 Slc30a1 Slc30a2 Slc30a3 MITOTIC ANAPHASE%REACTOME%R-HSA-68882.2 Mitotic Anaphase Zw10 Ska1 Ankle2 Nup85 Pmf1 Nup160 Vrk1 Lmnb1 Spc25 Nudc Rps27 Ppp2r1a Spc24 Xpo1 Clasp2 Itgb3bp Nuf2 Cenpf Ppp1cc Cenpq Cenpp Ahctf1 Cenpm Cenpl Cenpo Clip1 Cenpn Aurkb Zwilch Cdca8 Cenpt Apitd1 Sec13 Stag2 Sgol2b Ercc6l Stag1 Ppp2r2a Banf1 Dsn1 Nup107 Mad1l1 Pttg1 Smc1a Rad21 Cenph Cenpi Cenpe Cenpk Kif2c Taok1 Birc5 Kif2b Kif18a Bub1b Zwint Nup37 Incenp Wapal Psmd12 Nup43 Nup133 Psmd11 Rcc2 Nsl1 Kif2a Ndel1 Spdl1 Psmd14 Ndc80 Emd Kntc1 Psmd13 Bub3 Psmd10 Cdca5 Bub1 Cenpu Mad2l1 Casc5 Smc3 Cenpa Espl1 Lemd3 Lemd2 Cenpc1 Cdc23 Ppp2r1b Ube2d1 Cdc27 Cdc16 Cdc20 Ube2c Anapc16 Ube2e1 Anapc7 Anapc4 Shfm1 Anapc5 Anapc1 Anapc2 Sgol1 Pds5a Ranbp2 Mis12 Pds5b Pafah1b1 Psmc6 Psmc5 Psmc2 Psmd2 Psmb9 Psmf1 Psmb8 B9d2 Psme4 Ppp2r5e Ppp2r5c Ppp2r5d Ppp2r5a Psmc1 Psmc4 Psmc3 Psme3 Anapc15 Anapc11 Anapc10 Clasp1 Ppp2r5b Mapre1 Ppp2cb Ckap5 Ppp2ca Plk1 Psma7 Psma5 Psmb5 Psmb4 Ubc Psma4 Psma3 Psmb7 Psma6 Psmb6 Psmb2 Psmb3 Psma2 Psmb1 Psma1 Psmd9 Psmd1 Psme2 Psme1 Psmd3 Psmd4 Psmb10 Psmd6 Psmd5 Psmd7 Psmb11 Psmd8 LOSS OF NLP FROM MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 59%380259 Loss of Nlp from mitotic centrosomes Pafah1b1 Ccp110 Nek2 Cep57 Akap9 Haus7 Haus8 Ppp2r1a Ywhag Ywhae Hsp90aa1 Ninl Ywhaq Cep152 Prkar2b Haus3 Haus4 Cdk1 Cetn2 Ofd1 Haus2 Cep63 Alms1 Haus5 Haus6 Haus1 Tubb4a Tubb4b Clasp1 Ssna1 Tubg1 Csnk1d Cep250 Tuba4a Dynll1 Csnk1e Cep135 Cdk5rap2 Mapre1 Pcnt Sfi1 Cep70 Nedd1 Actr1a Cep131 Pcm1 Prkaca Dync1i2 Fgfr1op Cep76 Cep78 Cep72 Dctn2 Dctn3 Ckap5 Cep164 Tubb5 Tuba1a Cep41 Plk1 Cenpj Dync1h1 Plk4 Sdccag8 EUKARYOTIC TRANSLATION TERMINATION%REACTOME%R-HSA-72764.4 Eukaryotic Translation Termination Rpl39 Rplp1 Etf1 Trmt112 Rpl7 Rps21 Rps27 Rplp2 Rps25 Rpl4 Rps26 Rps27l Rpl18a Rpl34 Rpl32 Apeh Rpl26 Rpl24 Rps9 Rps7 Rps5 Rpl22 Gspt1 Rpl10l Rpl23 Rpl39l Gspt2 Rpl13a Rpl22l1 N6amt1 Rps15a Rpl11 Rpl17 Rps3 Rpl19 Rpl18 Rps16 Rps14 Rps19 Rps18 Rps11 Rps10 Rpsa Rpl37 Rps4x CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII%REACTOME%R-HSA-442729.1 CREB phosphorylation through the activation of CaMKII Creb1 Actn2 Grin2c Akap9 Camk2d Camk2a Camk2b Grin1 Dlg4 Nefl Grin2d Camk2g Grin2b Grin2a CYTOKINE SIGNALING IN IMMUNE SYSTEM%REACTOME%R-HSA-1280215.2 Cytokine Signaling in Immune system Hspa8 Vegfa Hist1h3d Nup50 Tpr Ndc1 Nup214 Hist2h3c1 Aaas Nup210 Skp1a Nup188 Nup54 Csk Nup35 Nupl2 Nup62 Nup205 Nup155 Cul1 Nup88 Pom121 Rae1 Nup93 Nup153 Gab2 Nedd4 Mt2 Kpnb1 Kpna1 H2-Q10 Adam17 B2m Stx1a Prkcd Actn2 Nf1 Pdgfrb Stat5b Pdgfra Stat5a Kbtbd7 Vav1 Pou2f1 Il2rg Arrb2 Trim21 Egfr Traf3 Arrb1 Ret Vwf Il33 Map2k6 Sox2 Mmp2 Mmp9 Pspn Map2k1 Rbx1 Crkl Fgg Cdkn1a Map2k2 Cul3 Psmd12 Pdgfb Prl Psmd11 Rasgef1a Psmd14 Rasa3 Rasa4 Psmd13 Psmd10 Itgb2 Il2 Rasa2 Itgam Rasa1 Pomc Nefl Spred3 Kit Spred2 Grin2a Spred1 Il5 Ppp2r1b Ywhab Junb Kras Ube2e1 Gdnf Shfm1 H2-Aa Irs2 H2-Eb1 Syngap1 Lck Hbegf Cd4 Ptpn6 Irs1 Il3ra Btc Casp1 Il2ra Il2rb Ptpn11 Angpt1 Vim Maoa Psmc6 Egf Fgf23 Psmc5 Fgf22 Hmox1 Mark3 Psmc2 Fgf20 Psmd2 Dab2ip Tek Psmb9 Psmb8 Hsp90aa1 Araf Hras Grin1 Ppp2r5e Bcl6 Dlg4 Ppp2r5c Ppp2r5d Pin1 Ppp2r5a Psmc1 Psmc4 Psmc3 Pik3cb Foxo3 Pik3cd Foxo1 Itgb3 Fyn Hck Phb Grin2c Stat1 Rasgrp4 Rasgrp3 Stat6 Pebp1 S1pr1 Blnk Alox15 Ppp2r5b Rasgrp1 Syk Fcgr1 Tln1 Pik3ca Fga Fos Fgb Grin2d Prkaca Grin2b Hgf Gfra2 Gfra3 Lcn2 Gfra4 Ereg Ywhaz Jak2 Pea15a Itga2b Rap1a Jak3 Wdr83 Camk2d Rap1b Camk2a Fgfr4 Camk2b Psma5 Rasal3 Rasal2 Ip6k2 Psma4 Psma3 Oprd1 Psma6 Vcl Camk2g Psma2 Psma1 Gfra1 Psmd9 Mmp1a Lama5 Dusp7 Iqgap1 Fgf16 Dusp6 Tgfb1 Dusp9 Fgf15 Dusp8 Klb Fgf18 Psmd1 Itgax Sqstm1 Met Fn1 Rasal1 Dusp1 Psmd3 Psmd4 Psmd6 Psmd5 Dusp2 Pik3r3 Nos2 Psmd7 Mmp3 Crk Pik3r1 Cd44 Dusp5 Psmd8 Ddx58 Fgf10 Pik3r2 Rhou Dusp4 Il31ra Il22ra1 Nup85 Nup160 Akap9 Isg15 Ppp2r1a Gbp9 Ube2l6 Gbp5 Trim25 Gbp7 Btrc Nfkb2 Nfkb1 Ifitm2 Ifitm3 Fbxw11 Saa3 Tnip2 Il22ra2 Myd88 Nod2 Nod1 Hif1a Map3k7 Peli1 Hsp90b1 Irak3 Irak2 Irak1 Twist1 Tab1 Tab2 Lifr Tab3 Arih1 Ripk2 Map2k4 Map3k8 Bst2 Rela Uba7 Il4 Il6 Csf3 Csf2 Ccl12 Peli3 Tnfrsf1a Csf3r Csf1 Irak4 Fcer2a Nup107 Peli2 Col1a2 Csf1r Tnfrsf1b Lif Ptk2b Cd86 Edar Ccl5 H2-M3 Lta Ccl4 H2-M5 Birc5 Ltb Tnf Uba3 2010002M12Rik Jak1 Osm Fpr1 Tnfrsf25 Tnfsf14 Timp1 Tnfsf15 Il12b H2-Q1 Nup37 Ccr1 Pml Ltbr Stx4a Brwd1 Tnfsf12 Il12a Tnfsf13 Il10 Nup43 Trim26 Tnfsf18 Ccl3 Il13 Map3k14 Nup133 Cd80 Cd70 Il27ra Anxa1 Edaradd Il1rn Ptafr Tnfrsf8 Trim31 Tyk2 Relb Stat3 Casp3 Il10ra Icam1 Cxcl3 Cxcl1 Ptgs2 Il1r2 Ccl22 Il1f10 Tnfrsf11a Il1r1 Tnfrsf11b Ccl20 Ccr2 Ube2m Ccr5 Eda Tnfsf8 Il1b Cxcl10 Tnfsf4 Tnfsf11 Il1a Cd40lg Prlr Il18 Il18rap Map3k3 Il17f Il17a Il17c Il10rb Tnfrsf12a Il17rb Il17ra Tnfrsf4 Cd27 Cd36 Il17re Eda2r Tnfrsf17 Ranbp2 Tnfrsf14 Tnfsf13b Tnfrsf18 Il17rc Kpna3 Tnfrsf13c Kpna4 Tnfrsf13b Kpna7 Tnfrsf9 Isg20 Oprm1 F13a1 Mid1 Mcl1 Il13ra2 Il13ra1 Ppm1b Zeb1 Il27 Frs2 Nras Prtn3 Frs3 Rasgrf1 Flt3 Psmf1 Raf1 Ctf1 Trim12c Psme4 Alox5 Il5ra Fgf1 Osmr Il17rd Fgf2 Cnksr1 Cnksr2 Oasl1 Erbb2 Fgf9 Ptk2 Flnb Fgf7 Psme3 Fgf6 Ifi35 Rorc Fgf4 Ifi30 Fgf3 Ifi27 Ccnd1 Rora Ciita Trim68 Flt3l Stx3 Ppp5c Trim62 Ranbp9 Trim46 Trim45 Egr1 Trim35 Trim38 Ifit3b Batf Ppp2cb Ptpn1 Shc1 Lamtor2 Ifnlr1 Chuk Nrg2 Ppp2ca Shc3 Nrg1 Ndn Il1f9 Shc2 Il1f6 Psma7 Cntf Artn Il1f8 Nrtn Plcg1 Brap Il7r Trim14 Psmb5 Psmb4 Ubc Nrg3 Samhd1 Cntfr Psmb7 Myc Pim1 Nrg4 Fscn1 Psmb6 Psmb2 Trim17 Psmb3 Psmb1 Il9r Mapk3 Trim6 Trim10 Akt1 Trim8 Mapk1 Ksr1 Ptpra Il6ra Dusp16 Trim3 Dusp10 Trim2 Ebi3 Il1rl1 Map3k11 Il1rl2 Usp18 Ifnar1 Trp53 Stat2 Vcam1 Iltifb Paqr3 Il15 Il11 Psme2 Il6st Crlf1 Psme1 Ncam1 Sos1 Il16 Il19 Braf Psmb10 Apbb1ip Il34 Eif4g2 Rapgef1 Eif4e3 Il15ra Psmb11 Eif4g3 Tec Ghr Csf2rb2 Il20 Rapgef2 Eif2ak2 Csf2ra Il25 Il24 Sptan1 Adar Fasl Smarca4 Yes1 Socs2 Lyn Cbl Inppl1 Socs1 Socs5 Gata3 Il12rb1 Traf2 Il12rb2 Ifnb1 Spta1 Cish Sptbn4 Birc3 Birc2 Bcl2 Bcl2l1 Traf6 Ikbkb Ube2v1 Ube2n Ikbkg Eif4e Eif4g1 Irf8 Irf6 Irf7 Irf1 Il4ra Itgb1 Irf4 Ifit2 Gbp2 Gbp3 Irf2 Irf3 Il18r1 Sptbn2 Ifna16 Irf9 Sptbn1 Irf5 Il18bp Tollip Inpp5d Rsad2 Lbp Ifnl3 Pias1 Sptb Muc1 Il11ra2 Il23r Eif4a3 Rnasel Il23a Ifngr2 Ifng Il9 Clcf1 Socs3 Il20rb Il20ra Ifngr1 Rag2 Rag1 Oas1g Gm13305 Eif4a1 Eif4a2 Oas2 Oas3 Txlna Il7 Ccl11 DOWNSTREAM SIGNALING OF ACTIVATED FGFR4%REACTOME DATABASE ID RELEASE 59%5654716 Downstream signaling of activated FGFR4 Fgf23 Fgf16 Kras Fgf15 Fgf20 Klb Frs2 Fgf18 Nras Frs3 Fgfr4 Plcg1 Hras Pik3ca Sos1 Fgf1 Gab1 Fgf2 Fgf9 Pik3r1 Ptpn11 Fgf6 Fgf4 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 59%69298 Association of licensing factors with the pre-replicative complex Orc4 Gmnn Orc5 E2f2 Cdc6 Ubc Cdt1 E2f1 E2f3 Orc2 Orc3 Orc1 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION%REACTOME DATABASE ID RELEASE 59%983169 Class I MHC mediated antigen processing & presentation Ube2b Ube2r2 Ube2q2 Ube2a Lmo7 Lrrc41 Rchy1 Rlim Hace1 Ube2l6 Btrc Fbxo4 Fbxw11 Fbxo6 Arih2 Rnf34 Myd88 Cd207 Znrf1 Dtx3l Cdc34 Cybb Cyba Arel1 Rnf217 Uba7 Mib2 Rnf213 Nedd4l Rnf220 Lonrf1 Cul7 H2-M3 Mrc2 H2-M5 Mrc1 Vamp8 Uba3 Sec61a2 Vamp3 Rnf144b Atg7 H2-Q1 Stx4a Calr Tapbp Tlr2 Tlr6 Sec61g Trim41 Ube2e3 Sec61a1 Sec61b Pdia3 Hectd3 Cul2 Hectd1 Hectd2 Rnf123 Ube2o Ube2f Npepps Itgav Ube3a Ube2m Ube3c Ube3b Ube2z Ube2w Ube2k Ube2h Lrr1 Ubox5 Cd36 Snap23 Tap1 Tap2 Vhl Tlr1 Tirap Fbxl5 Fbxl3 Vprbp Gan Hecw2 Psmf1 Traf7 Psme4 Ncf4 Ube2v2 Ncf2 Skp1a Kctd7 Ncf1 Kctd6 Traip Skp2 Cul1 Psme3 Rnf4 Tpp2 Blmh Huwe1 Ccnf Kbtbd13 Trim69 Sh3rf1 Det1 Trim71 Ltn1 Asb18 Asb11 Trim63 Asb16 Asb17 Asb14 Asb12 Asb13 Trim39 Trim50 Trim36 Fbxl7 Asb15 Fbxl18 Trim37 Fbxw8 Fbxl16 Chuk Fbxl19 Fbxl14 Fbxl13 Fbxl15 Fbxl12 Mex3c Fbxl8 Psma7 Fbxl4 Cul5 Rnf41 Psmb5 Fbxo7 Psmb4 Fbxo9 Zbtb16 Ubc Itch Psmb7 Wwp1 Klhl2 Nedd4 Psmb6 Klhl9 Psmb2 Psmb3 Klhl20 Psmb1 Klhl22 Klhl21 Fbxo2 Lnpep Trim11 Trim9 Klhl25 Klhl13 Herc2 Klhl11 Pja2 Lrsam1 Pja1 Rbck1 Tceb1 Spsb1 Psme2 Ubr2 Ubr1 Psme1 Trip12 Spsb4 Ubr4 Mkrn1 Herc1 Ubac1 Herc3 Psmb10 Herc4 Spsb2 H2-Q10 Anapc13 Fbxl21 Smurf2 Fbxl20 Psmb11 B2m Herc6 Klhl41 Klhl42 Siah1a Kbtbd7 Fbxw10 Trim21 Siah2 Trim32 Sec24a Sec24b Sec13 Sec24d Sec24c Rbx1 Sec31a Cul3 Psmd12 Psmd11 Keap1 Psmd14 Psmd13 Psmd10 Ufl1 Socs1 Ube4a Rnf126 Rnf115 Cdc23 Ube2d1 Cdc27 Cdc16 Ikbkb Cdc20 Ube2v1 Ube2c Tlr4 Ube2e1 Ube2n Anapc7 Anapc4 Shfm1 Ly96 Anapc5 Cd14 Ikbkg Anapc1 Anapc2 Park2 Psmc6 Sar1b Psmc5 Kbtbd8 Canx Psmc2 Psmd2 Rnf7 Uba6 Psmb9 Sec23a Rnf6 Psmb8 Fbxw2 Dzip3 Psmc1 Psmc4 Fbxw5 Ube2q1 Psmc3 Fbxw4 Mgrn1 Fbxw9 Rnf111 Fbxw7 Anapc11 Anapc10 Fzr1 Rnf130 Rnf138 Ube2e2 Cblb Rnf114 Fcgr1 Mylip Lnx1 Rnf19a Rnf19b Sec22b Rnf182 Fbxo30 Fbxo32 Fbxo31 Btbd6 Btbd1 Btk Fbxo27 Hspa5 Erap1 Fbxo22 Fbxo21 Psma5 Uba5 Ube2d3 Socs3 Psma4 Psma3 Psma6 Fbxo10 Psma2 Ube2cbp Psma1 Fbxo17 Psmd9 Asb5 Asb4 Rnf14 Asb3 Asb2 Ctss Asb1 Asb9 Smurf1 Ube2g2 Ctsl Psmd1 Ube2g1 Stub1 Asb7 Asb6 Psmd3 Fbxo40 Psmd4 Wsb1 Itgb5 Psmd6 Psmd5 Rnf25 Psmd7 Ube2l3 Ube2j1 Uba1 Asb8 Ube2j2 Psmd8 Fbxo44 Fbxo41 GLUCURONIDATION%REACTOME DATABASE ID RELEASE 59%156588 Glucuronidation Ugt1a6a Slc35d1 Ugdh Ugp2 Ugt2b1 Abhd10 Ugt1a5 Ugt1a1 Ugt1a9 Ugt1a2 Ugt2b38 Ugt3a2 Ugt2b36 Ugt2b34 Ugt2a3 Ugt2a2 Ugt2a1 GLI PROTEINS BIND PROMOTERS OF HH RESPONSIVE GENES TO PROMOTE TRANSCRIPTION%REACTOME%R-HSA-5635851.2 GLI proteins bind promoters of Hh responsive genes to promote transcription Gli3 Gli2 Gli1 SIGNALING BY NOTCH4%REACTOME%R-HSA-1980150.2 Signaling by NOTCH4 Adam10 Notch4 Psen2 Ncstn Jag2 Dll1 Aph1b Dll4 Jag1 ZINC TRANSPORTERS%REACTOME DATABASE ID RELEASE 59%435354 Zinc transporters Slc39a14 Slc30a1 Slc39a1 Slc39a10 Slc30a2 Slc30a3 Slc39a5 Slc30a5 Slc30a8 Slc39a4 Slc39a3 Slc30a6 Slc30a7 Slc39a2 Slc39a8 Slc39a6 Slc39a7 INHIBITION OF TSC COMPLEX FORMATION BY PKB%REACTOME DATABASE ID RELEASE 59%165181 Inhibition of TSC complex formation by PKB Tsc2 Akt2 Tsc1 CYSTEINE FORMATION FROM HOMOCYSTEINE%REACTOME%R-HSA-1614603.2 Cysteine formation from homocysteine Cth Cbs COLLAGEN CHAIN TRIMERIZATION%REACTOME%R-HSA-8948216.1 Collagen chain trimerization Col4a5 Col16a1 Col15a1 Col9a1 Col9a2 Col9a3 Col28a1 Col24a1 Col20a1 Col27a1 Col10a1 Col3a1 Col25a1 Col11a1 Col11a2 Col23a1 Col7a1 Col8a1 Col8a2 Col5a1 Col22a1 Col26a1 Col4a6 Col5a3 Col5a2 Col4a3 Col4a2 Col4a4 Col17a1 Col4a1 Col12a1 Col6a1 Col6a2 Col13a1 Col2a1 Col6a3 Col1a2 Col6a6 Col14a1 Col1a1 Col19a1 Col18a1 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE%REACTOME DATABASE ID RELEASE 59%168164 Toll Like Receptor 3 (TLR3) Cascade Irf7 Tbk1 Ppp2r1a Irf3 Btrc Mapk9 Ikbke Nfkb2 Tank Nfkb1 Traf3 Fbxw11 Skp1a Saa3 Ppp2r5d Mapkapk3 Tnip2 Myd88 Nod2 Cul1 Nod1 Dhx9 Vrk3 S100b Elk1 Mef2c Mapk10 Mef2a Dusp3 Map3k7 Mapk7 Creb1 Mapkapk2 Irak2 Irak1 App Map2k6 Tab1 Tab2 Jun Mapk8 Tab3 Ripk2 Map2k7 Ager Map2k3 Map2k4 Map3k8 Rela Atf2 Nfkbia Nfkbib Fos Ppp2cb Casp8 Map2k1 Fadd Chuk Ppp2ca Ripk1 Ube2d3 Ubc Mapk3 Rps6ka5 Mapk1 Ppp2r1b Ticam2 Dusp7 Ube2d1 Ripk3 Birc3 Rps6ka3 Birc2 Dusp6 Rps6ka2 Ticam1 Rps6ka1 Traf6 Ikbkb Ube2v1 Tlr4 Ube2n Tlr3 Ly96 Cd14 Ikbkg Mapk11 Mapk14 Ptpn11 Dusp4 NEF-MEDIATES DOWN MODULATION OF CELL SURFACE RECEPTORS BY RECRUITING THEM TO CLATHRIN ADAPTERS%REACTOME%R-HSA-164938.1 Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters Ap2m1 Cd8b1 Ap2b1 Ap2a1 Atp6v1h Ap1s2 Ap1b1 Ap2a2 Ap1s1 Ap1g1 Pacs1 Lck H2-Q10 Cd4 Ap1s3 Arf1 B2m Ap2s1 Ap1m2 Ap1m1 HIV ELONGATION ARREST AND RECOVERY%REACTOME%R-HSA-167287.2 HIV elongation arrest and recovery Cdk9 Polr2i Polr2f Polr2j Polr2e Nelfa Polr2h Nelfb Ell Polr2c Polr2d Supt4a Polr2b Tcea1 Tceb1 Tceb3 Supt16 Polr2k Polr2g Ccnt1 Ctdp1 Ssrp1 Ccnk Polr2a Nelfe Supt5 Nelfcd Gtf2f1 Ccnt2 Gtf2f2 OREXIN AND NEUROPEPTIDES FF AND QRFP BIND TO THEIR RESPECTIVE RECEPTORS%REACTOME DATABASE ID RELEASE 59%389397 Orexin and neuropeptides FF and QRFP bind to their respective receptors Qrfpr Npff Npffr1 Npffr2 Qrfp Hcrtr1 Hcrtr2 Hcrt GSD 0%REACTOME DATABASE ID RELEASE 59%3858516 GSD 0 Gys2 KERATAN SULFATE KERATIN METABOLISM%REACTOME%R-HSA-1638074.1 Keratan sulfate keratin metabolism Hexa Lum Hexb St3gal4 Chst2 Chst5 B4gat1 Chst1 Glb1 Fmod B4galt3 B3gnt3 St3gal1 B3gnt2 St3gal2 B4galt1 B3gnt7 Omd B4galt5 Prelp B4galt4 B3gnt4 B4galt6 Kera Ogn Slc35d2 B4galt2 Gns St3gal6 EXTRINSIC PATHWAY OF FIBRIN CLOT FORMATION%REACTOME DATABASE ID RELEASE 59%140834 Extrinsic Pathway of Fibrin Clot Formation F3 F10 Tfpi F9 F7 STEROID HORMONES%REACTOME%R-HSA-209943.1 Steroid hormones Lgmn Cyp21a1 Cyp27b1 Hsd17b14 Hsd17b3 Hsd17b1 Cga Lhb Cyp2r1 Akr1b3 Cyp19a1 Hsd17b11 Hsd17b12 Hsd17b2 Akr1b8 Srd5a2 Pomc Hsd3b1 Hsd3b6 Srd5a1 Cyp11b1 Srd5a3 Cyp11b2 Fdx1 Cyp17a1 Cyp24a1 Fdx1l Star Stard4 Cyp11a1 Stard3nl Stard3 Fdxr Hsd11b1 Hsd11b2 Cubn Gc Lrp2 SIGNALING BY FGFR4%REACTOME%R-HSA-5654743.2 Signaling by FGFR4 Ppp2cb Spry2 Fgf23 Ppp2ca Fgf20 Frs2 Nras Ppp2r1a Frs3 Mknk1 Plcg1 Fgfr4 Hras Fgf1 Ubc Cbl Gab1 Fgf2 Fgf9 Mapk3 Fgf6 Fgf4 Mapk1 Fgf16 Kras Fgf15 Klb Fgf18 Pik3ca Sos1 Braf Pik3r1 Ptpn11 DOWNSTREAM SIGNALING OF ACTIVATED FGFR2%REACTOME DATABASE ID RELEASE 59%5654696 Downstream signaling of activated FGFR2 Fgf23 Fgf16 Fgf22 Kras Fgf20 Frs2 Fgf18 Nras Frs3 Plcg1 Hras Pik3ca Sos1 Fgf1 Gab1 Fgf2 Fgf9 Pik3r1 Fgf7 Ptpn11 Fgf6 Fgf10 Fgf4 Fgf3 DISINHIBITION OF SNARE FORMATION%REACTOME DATABASE ID RELEASE 59%114516 Disinhibition of SNARE formation Prkcg Stx4a Stxbp3 Prkcb Prkca SHC-MEDIATED CASCADE:FGFR1%REACTOME DATABASE ID RELEASE 59%5654688 SHC-mediated cascade:FGFR1 Fgf23 Fgf22 Kras Fgf20 Nras Hras Sos1 Fgf1 Fgf2 Fgf9 Fgf10 Fgf6 Fgf4 Fgf3 ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 59%264642 Acetylcholine Neurotransmitter Release Cycle Slc5a7 Chat Slc18a3 Snap25 Ppfia2 Ppfia1 Ppfia4 Unc13b Rab3a Syt1 Vamp2 Cplx1 Stx1a BREAKDOWN OF THE NUCLEAR LAMINA%REACTOME%R-HSA-352238.1 Breakdown of the nuclear lamina Casp6 Lmnb1 TOXICITY OF BOTULINUM TOXIN TYPE E (BONT E)%REACTOME DATABASE ID RELEASE 59%5250992 Toxicity of botulinum toxin type E (BoNT E) Sv2b Sv2a Snap25 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY%REACTOME DATABASE ID RELEASE 59%2173795 Downregulation of SMAD2 3:SMAD4 transcriptional activity Ski Ube2d1 Ppm1a Usp9x Ncor1 Smad4 Smad2 Ncor2 Skil Smad3 Trim33 Ube2d3 Parp1 Ubc Nedd4l Hdac1 Tgif2 Smurf2 Tgif1 Rnf111 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX%REACTOME%R-HSA-68962.2 Activation of the pre-replicative complex Mcm6 Cdc6 Cdk2 Mcm3 Mcm2 Mcm5 Mcm4 Cdc7 Dbf4 Mcm10 Orc4 Orc5 Mcm8 Mcm7 Pole Cdt1 Cdc45 Orc2 Orc3 Orc6 Orc1 Prim1 Pole2 Rpa2 Rpa1 Rpa3 Pola1 Pola2 Pole4 Prim2 Pole3 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE%REACTOME DATABASE ID RELEASE 59%2559586 DNA Damage Telomere Stress Induced Senescence Hmga2 Lmnb1 Ep400 Hmga1 Cabin1 Hist1h1d H1f0 Ubn1 Rb1 Ccne1 Cdk2 Ccne2 Ccna1 Rad50 Ccna2 H2afj H2afb2 Nbn Mre11a Atm Cdkn1b Hist3h2ba Hist2h2be Hist2h2ac Hist1h2bg Tinf2 Pot1a Hist1h2bh Cdkn1a Terf1 Terf2 Hist1h2bp Acd Hist1h2bm Hist1h2bj Hist1h2bb H2afz Terf2ip H2afx Trp53 Hist2h2aa1 Kat5 Hist1h3h Hira Hist1h1c Hist1h2ak Asf1a Hist1h1e Hist1h1b Hist1h2ag Hist1h1a Hist1h2ah DOWNSTREAM TCR SIGNALING%REACTOME%R-HSA-202424.3 Downstream TCR signaling Psmc6 Psmc5 Psmc2 Psmd2 Psmb9 Psmf1 Psmb8 Btrc Psme4 Malt1 Card11 Nfkb1 Fbxw11 Skp1a Psmc1 Psmc4 Psmc3 Pik3cb Cul1 Psme3 Map3k7 Cdc34 Tab2 Inpp5d Bcl10 Ripk2 Rela Pik3ca Nfkbia Chuk Psmd12 Psma7 Psmd11 Psmd14 Psma5 Psmb5 Psmb4 Ubc Psmd13 Psmd10 Prkcq Psma4 Psmb7 Psma3 Psma6 Psmb6 Psmb2 Psmb3 Psmb1 Psma2 Psma1 Psmd9 Ube2d1 Traf6 Ikbkb Ube2v1 Ube2n Psmd1 Shfm1 Psme2 Psme1 Ikbkg H2-Aa Cd3d Trat1 Psmd3 Cd3e Psmd4 H2-Eb1 Pdpk1 Psmb10 Lck Psmd6 Pten Psmd5 Cd4 Psmd7 Pik3r1 Psmb11 Psmd8 Cd3g Pik3r2 PROTEIN METHYLATION%REACTOME%R-HSA-8876725.1 Protein methylation Camkmt Vcpkmt Vcp Eef2 Etfb Hspa8 Mettl21a Mettl20 N6amt2 Mettl22 Eef2kmt Prmt3 Mettl10 Kin PLATELET SENSITIZATION BY LDL%REACTOME%R-HSA-432142.2 Platelet sensitization by LDL Ppp2r1b Ppp2cb Ppp2ca Fgr Ppp2r1a Ppp2r5b Ppp2r5e Mapk14 Ppp2r5c Ppp2r5d Ppp2r5a Ptpn6 Pecam1 Pla2g4a Ptpn11 Apob CONSTITUTIVE SIGNALING BY LIGAND-RESPONSIVE EGFR CANCER VARIANTS%REACTOME DATABASE ID RELEASE 59%1236382 Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants Shc1 Egf Kras Nras Cdc37 Hsp90aa1 Plcg1 Pik3ca Hras Sos1 Ubc Egfr Gab1 Cbl Pik3r1 REGULATION OF TP53 EXPRESSION AND DEGRADATION%REACTOME DATABASE ID RELEASE 59%6806003 Regulation of TP53 Expression and Degradation Ppp2cb Ppp2ca Akt2 Akt3 Sgk1 Ppp2r1a Mlst8 Rffl Mdm4 Mapkap1 Ubc Cdk1 Ccng1 Ppp2r5c Cdk2 Usp2 Mtor Cdkn2a Ccna1 Rnf34 Prdm1 Ccna2 Akt1 Ppp2r1b Trp53 Chek2 Rictor Pdpk1 Mdm2 Usp7 Atm Daxx Prr5 PKMTS METHYLATE HISTONE LYSINES%REACTOME%R-HSA-3214841.3 PKMTs methylate histone lysines Kmt2c Suz12 Atf7ip Kmt2b Suv39h1 Eed Nsd1 Suv39h2 Setdb2 Smyd3 Prdm16 Ezh2 Setdb1 Kmt2a Rbbp7 Kmt2d Aebp2 Hist2h3c1 Nfkb2 Nfkb1 Setd8 Rbbp4 Smyd2 Hist1h3d Whsc1 Rela Suv420h1 Suv420h2 Ehmt2 Setd1a Setd1b Dot1l Wdr5 Ash2l Mecom Dpy30 Rbbp5 Whsc1l1 Ash1l Prdm9 Setd2 Setd3 Setd6 Ehmt1 Setd7 CILIUM ASSEMBLY%REACTOME%R-HSA-5617833.3 Cilium Assembly Cct5 Tcp1 Cct8 Cct4 Akap9 Nphp4 Ppp2r1a Ywhae Ninl Cep152 Mkks Ift43 Cys1 Ift46 Wdr60 Kif17 Bbs12 Pde6d Ift74 Bbs10 Arl3 Dynlrb1 Arl6 Dynlrb2 Smo Bbs7 Ttc26 Gm3448 Bbs9 Nphp3 Dync2li1 Bbs5 Bbs4 Bbs2 Bbs1 Tcte3 Atat1 Ttc30a1 Pkd1 Pkd2 Unc119b Mchr1 Cnga4 Asap1 Hspb11 Lztfl1 Ift27 Traf3ip1 Hdac6 Ttc8 Cnga2 Cluap1 Rab11fip3 Tnpo1 Ift22 Arl13b Kif3c Kif3b Kif3a Gbf1 Ift140 Ift122 Ift52 Ift172 Ift57 Wdr19 Ttc21b Dync2h1 Wdr35 Ift88 Kifap3 Pafah1b1 Mks1 Rpgrip1l Nphp1 Ccp110 Nek2 Cep57 Cc2d2a Haus7 Haus8 Ywhag Cep97 Rab3ip Hsp90aa1 Trip11 Ywhaq Rab8a B9d2 Prkar2b Haus3 Haus4 Cdk1 Cep162 Cetn2 Dynll2 B9d1 Rho Ofd1 Haus2 Ahi1 Cep63 Arf4 Alms1 Haus5 Haus6 Haus1 Tubb4a Tubb4b Iqcb1 Rab11a Clasp1 Tmem67 Ssna1 Tubg1 Csnk1d Cep250 Tuba4a Dynll1 Csnk1e Cep135 Kif24 Cdk5rap2 Inpp5e Mapre1 Pcnt Sstr3 Sfi1 Cep70 Nedd1 Actr1a Cep131 Fbf1 Pcm1 Prkaca Dync1i2 Fgfr1op Cep76 Cep78 Cep72 Sept2 Dctn2 C2cd3 Sclt1 Dctn3 Exoc3 Ckap5 Cep164 Exoc4 Tubb5 Tuba1a Ift81 Ttbk2 Ift80 Exoc1 Cep41 Exoc5 Plk1 Wdr34 Exoc6 Mark4 Tctex1d2 Exoc8 Cenpj Tctex1d1 Cep83 Exoc7 Rp2h Exoc2 Dync1h1 Ttc30b Cep89 Tctn3 Plk4 Sdccag8 Tctn1 Cct2 Cct3 PASSIVE TRANSPORT BY AQUAPORINS%REACTOME%R-HSA-432047.1 Passive transport by Aquaporins Aqp9 Aqp5 Aqp4 Aqp1 Aqp8 Aqp11 Aqp7 Aqp12 Aqp6 Mip Aqp2 Aqp3 ENDOSOMAL VACUOLAR PATHWAY%REACTOME DATABASE ID RELEASE 59%1236977 Endosomal Vacuolar pathway H2-M3 H2-M5 H2-Q10 Ctss H2-Q1 Ctsl B2m Lnpep ACTIVATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME DATABASE ID RELEASE 59%2485179 Activation of the phototransduction cascade Gngt1 Pde6a Pde6g Slc24a1 Pde6b Gnb1 Cnga1 Rho Gnat1 Sag FGFR1C LIGAND BINDING AND ACTIVATION%REACTOME%R-HSA-190373.4 FGFR1c ligand binding and activation Fgf1 Fgf23 Fgf2 Fgf20 Fgf9 Fgf6 Fgf4 SHC1 EVENTS IN ERBB2 SIGNALING%REACTOME%R-HSA-1250196.4 SHC1 events in ERBB2 signaling Shc1 Egf Prkcd Prkce Ptpn12 Nrg2 Ereg Kras Nrg1 Nras Prkca Hras Sos1 Egfr Nrg3 Nrg4 Hbegf Erbb2 Btc SUMOYLATION%REACTOME%R-HSA-2990846.2 SUMOylation Nup85 Hnrnpc Nup160 Nup50 Pias4 Tpr Pcna Pias3 Rnf168 Ndc1 Nup214 Top2b Aaas Nup210 Mitf Nup188 Cetn2 Nup54 Nup35 Trp53bp1 Nupl2 Rnf2 Nup62 Nup205 Nsmce4a Nup155 Nup88 Pom121 Hnrnpk Top1 Top2a Rae1 Senp1 Nsmce2 Ring1 Senp2 Nup93 Nsmce1 Sumo3 Nup153 Aurkb Sp3 Cdca8 Aurka Ndnl2 Stag2 Stag1 Rpa1 Pias1 Nup107 Xpc Hdac7 Smc1a Mta1 L3mbtl2 Rad21 Ube2i Nop58 Birc5 Nup37 Pml Incenp Nup43 Nup133 Smc5 Parp1 Blm Smc6 Cdkn2a Mdc1 Smc3 Rad52 Tfap2b Herc2 Phc3 Tfap2c Trp53 Wrn Phc2 Phc1 Brca1 Cbx4 Pcgf2 Cbx8 Mdm2 Cbx2 Ranbp2 Bmi1 Xrcc4 Sae1 Uba2 Senp5 UNC93B1 DEFICIENCY - HSE%REACTOME DATABASE ID RELEASE 59%5602415 UNC93B1 deficiency - HSE Tlr3 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS%REACTOME%R-HSA-111367.2 SLBP independent Processing of Histone Pre-mRNAs Lsm11 Lsm10 Zfp473 Ncbp1 Snrpb Ncbp2 Snrpd3 ACYL CHAIN REMODELLING OF PG%REACTOME%R-HSA-1482925.1 Acyl chain remodelling of PG Pla2g5 Pla2g4d Pla2g4f Pla2g2e Pla2g12a Lpgat1 Pla2g2d Pla2g1b Pla2g2f Crls1 Lpcat4 Pla2g3 Pla2g4a Pla2g10 Pla2r1 Lpcat1 NICOTINATE METABOLISM%REACTOME%R-HSA-196807.2 Nicotinate metabolism Nadk Parp8 Slc5a8 Parp6 Qprt Nmrk2 Parp9 Ptgis Parp4 Nmrk1 Nnmt Ptgs2 Nadsyn1 Cyp8b1 Naprt Apoa1bp Parp14 Nampt Bst1 Parp16 Cd38 Parp10 Nmnat2 Nmnat1 Nmnat3 Nudt12 Nt5e Slc22a13 SPHINGOLIPID METABOLISM%REACTOME DATABASE ID RELEASE 59%428157 Sphingolipid metabolism Ormdl2 Vapb Ppap2c Gm2a Ormdl1 Enpp7 Ugcg Sgpl1 Sptssb Sptssa Asah2 Fa2h Gba2 Sphk1 Aldh3b1 Hexb Gltp Cerk Degs2 Cptp Neu1 Esyt3 Neu3 Esyt1 Neu2 Esyt2 Ormdl3 Arsg Arsi Arsb Cers4 Arsa Cers5 Cers6 Acer3 Acer1 Prkd3 Cers3 Sptlc2 Arsk Cers2 Arsj Acer2 Smpd4 Cers1 Smpd1 Vapa Gba Prkd1 Sptlc3 Sptlc1 Prkd2 Psap Hexa B3galnt1 Sgms2 Sgms1 Asah1 Ppap2b Ppap2a Ugt8a Ctsa B4galnt1 Sphk2 Osbp Smpd3 Kdsr Sumf2 Sumf1 Ppm1l Glb1 Galc Csnk1g2 Gla Degs1 Smpd2 Sgpp2 Sgpp1 TBC RABGAPS%REACTOME DATABASE ID RELEASE 59%8854214 TBC RABGAPs Tbc1d15 Tbc1d17 Rab33a Sytl1 Tbc1d25 Tbc1d14 Tbc1d13 Tsc2 Tbc1d16 Rab5a Gabarapl2 Rab5c Rabgef1 Rab5b Tsc1 Rab33b Rab8a Rabep1 Gabarap Rab11b Tbc1d7 Map1lc3b Arf6 Tbc1d2 Gga2 Optn Tbc1d10c Gga3 Rab11a Rab4a Rab8b Gpr21 Rab7 Tbc1d24 Tbc1d10a Tbc1d10b Ulk1 Rabgap1 Tbc1d20 Rab35 Rab6b Rab6a Gga1 AMPLIFICATION OF SIGNAL FROM THE KINETOCHORES%REACTOME DATABASE ID RELEASE 59%141424 Amplification of signal from the kinetochores Mad1l1 Mad2l1 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS)%REACTOME%R-HSA-373076.5 Class A 1 (Rhodopsin-like receptors) Ffar3 C5ar2 Nts Oprk1 Rxfp1 Rxfp2 Gpbar1 Rxfp4 Rxfp3 Ptger3 Saa3 Ptger4 Cxcl2 Ptger1 Ptger2 Cxcl9 Cxcl5 App Hc Gpr132 Prok1 Mchr1 Prok2 Hebp1 Ffar2 Ffar1 Ccl5 Cxcr1 Fpr1 Ccr1 Prokr1 Agt Oprl1 Prokr2 Anxa1 Ptafr Cxcr2 Cxcr3 Nmur1 Nmur2 Cxcl3 Cckar Cxcl1 Ccl20 Ccr2 Cxcr6 Ccr5 Cxcl10 Cxcr4 Cxcr5 Gpr31b Apln Hrh3 Pyy Hrh1 Hrh2 Hrh4 Hcar1 Cckbr Aplnr Hcar2 Oprm1 F2rl3 F2rl2 Gal Pf4 Qrfpr Gpr4 Oxt Htr5a Npy1r Kiss1r Rho F2rl1 Grpr Ptgdr Rgr Mc5r Ptgfr Ntsr1 Ntsr2 Sucnr1 Ghsr Uts2b Npy5r Uts2r Taar8b Npy4r Taar1 Taar2 Taar5 Taar6 Pnoc Taar9 Npy2r Ptgdr2 Adora2b Trh Adora2a Adora3 Opn1sw Adora1 Mc2r Fshr Adrb2 Fshb F2r C5ar1 Adrb1 Edn1 F2 Adrb3 Edn3 Edn2 Gpha2 Mc1r Cysltr1 Adra1a Adra1b Ptgir Penk Adra1d Lpar5 Oxgr1 P2ry13 Mtnr1a P2ry12 P2ry14 P2ry10 Mtnr1b Uts2 Brs3 Hcrt Ccr9 Npsr1 Ccr8 Ccr7 Adra2a Ccr6 Ccr4 Adra2c Ccr3 Adra2b Mc3r Lpar6 Mc4r Ccr10 Tacr2 Tacr3 Bdkrb1 Tacr1 Cysltr2 Bdkrb2 Cx3cl1 Kng2 Tshr Ackr4 Ccl2 Ccl1 Gnrh1 Ppbp Cx3cr1 Ccrl2 Insl5 Insl3 Ppan Tshb Oxtr Npff Gper1 Ccl25 Ccl28 Galr2 Htr2a Agtr2 Htr2b Htr2c Rrh Agtr1a Htr1d Pmch Gpr143 Ednra Ednrb Htr1f Rln3 Rln1 Gpr18 Qrfp Hcrtr1 Hcrtr2 Htr7 Galr1 Htr6 Fpr3 Htr4 Xcl1 Pomc Gpr17 Fpr2 Htr1b Htr1a P2ry1 P2ry2 Drd4 Drd5 Drd2 Drd3 Drd1 C3ar1 Gpr55 Opn1mw Tac2 Tac1 Gnrhr Avp Avpr1a Avpr2 Avpr1b Npffr1 Cck Npffr2 P2ry6 P2ry4 Grp Tbxa2r Sst Nmb Ackr3 Cga Lhb Nmu Chrm3 Chrm2 Chrm1 Trhr Nms Kiss1 Chrm5 Chrm4 Prlhr Xk Gpr183 Xcr1 Ackr1 Gpr35 S1pr5 Ece2 Ece1 Gpr37l1 S1pr2 Lppr3 S1pr3 Lppr2 S1pr1 Kel S1pr4 Prlh Sstr2 Nln Sstr1 Lppr1 Opn3 Lppr5 Opn4 Lppr4 Sstr5 Npbwr1 Sstr3 Sstr4 Ppy Cort Opn5 Npb Lhcgr Ffar4 Npy Gpr37 Npw Nmbr Nps Psap C3 Lpar3 Lpar4 Lpar1 Lpar2 Gcat Ltb4r2 Oprd1 Ltb4r1 Pdyn Cxcl16 Cxcl13 Cxcl12 Cxcl11 Gpr68 Gpr65 Cnr2 Cnr1 TRNA MODIFICATION IN THE MITOCHONDRION%REACTOME DATABASE ID RELEASE 59%6787450 tRNA modification in the mitochondrion Trit1 Mto1 Gtpbp3 Trmu Trmt10c Hsd17b10 SYNTHESIS OF UDP-N-ACETYL-GLUCOSAMINE%REACTOME DATABASE ID RELEASE 59%446210 Synthesis of UDP-N-acetyl-glucosamine Nagk Renbp Pgm3 Gfpt2 Uap1 Gnpnat1 Amdhd2 Gfpt1 ER TO GOLGI ANTEROGRADE TRANSPORT%REACTOME DATABASE ID RELEASE 59%199977 ER to Golgi Anterograde Transport Trappc2 Tgfa Trappc3 Ins2 Mcfd2 Trappc1 Rab1 F5 Preb Copa F8 Sec24a Sec24b Sptan1 Sec13 Tmed3 Sec24d Scfd1 Gria1 Sec24c Arcn1 Tfg Ykt6 Cd59b Cog6 Lman2l Cog3 Cog4 Cog2 Sec31a Cog1 Ctage5 Gorasp1 Nsf Trappc6a Trappc6b Tmed9 Bet1l Gbf1 Ankrd28 Trappc9 Napb Napg Napa Trappc5 Spta1 Trappc4 Sptbn4 Dctn5 Dctn6 Ctsz Dctn1 Serpina1d Col7a1 Lman1l Dctn4 Areg Serpina1a Dync1li2 Folr1 Dync1li1 Rab1b Ppp6r1 Ppp6r3 Arf5 Cnih1 Kdelr2 Kdelr3 Uso1 Bet1 Stx17 Cnih3 Ctsc Cnih2 Cog7 Tmem115 Cog8 Arfgap3 Arfgap1 Arfgap2 Sar1b Golgb1 Copb2 Stx5a Copb1 Ppp6c Copz1 Ank1 Ank3 Sec23a Copz2 Trappc10 Sec23ip Copg1 Gosr1 Golga2 Dynll2 Gosr2 Arf1 Kdelr1 Arf3 Arf4 Dync1i1 Sptbn2 Trappc2l Sptbn1 Csnk1d Dynll1 Tbc1d20 Cope Sec16b Sec22a Lman1 Dync1i2 Sec22b Sptb Lman2 Sec16a Sec22c Dctn2 Dctn3 Dync1h1 PRE-MRNA SPLICING%REACTOME DATABASE ID RELEASE 59%72163 pre-mRNA splicing Cwc22 Cwc27 Fus Cwc25 Cwc15 Hnrnpd Hnrnpc Ppie Ppih Gcfc2 Prpf4 Prpf3 Ppwd1 Wbp4 Usp39 Prpf40a Hnrnpu Hnrnpr Hnrnpa2b1 Hnrnpl Hnrnpm Hnrnpf Dhx9 Hnrnpk Ppil1 Polr2i Polr2j Prcc Polr2c Polr2d Polr2b Dhx16 Dhx15 Polr2g Srrt Snrpn Srrm2 Plrg1 Snrpc Prpf8 Gpkow Snrpa Prpf6 Polr2a Xab2 Gtf2f1 Ncbp1 Snrpa1 Ncbp2 Gtf2f2 Lsm2 Lsm5 Smndc1 Lsm7 Ccar1 Lsm3 Lsm4 Srsf10 Hspa8 Lsm8 Prpf31 Lsm6 Snrnp200 Prpf19 Ptbp1 Wbp11 Rbm5 Snrpb2 Ctnnbl1 Snrpd2 Snrpd1 Sart1 Hnrnpul1 Snrpb Sf1 Snrpd3 Txnl4a Cdc5l Hnrnph1 Syf2 Hnrnph2 Rbmx Aqr U2surp Eftud2 Ddx5 Phf5a Sugp1 Puf60 Rbm22 Tra2b Ddx46 Rbm17 Hnrnpa3 Ddx42 Polr2f Polr2e Pabpn1 Polr2h Dnajc8 Srsf2 Srsf3 Isy1 Prpf38a Polr2k Slu7 Srsf11 Magoh Cpsf1 Cstf1 Dhx38 Clp1 Ddx23 Srsf7 Hnrnpa1 Srsf9 Hnrnpa0 Alyref Srsf6 Nudt21 Cstf2t Sf3b4 Sf3b3 Fip1l1 Sf3b2 Rbm8a Cstf3 Casc3 Sympk Eif4a3 U2af1l4 Srsf1 Cstf2 Cpsf3 Cpsf2 Pqbp1 Cpsf4 Sf3b6 Cpsf7 Sf3b5 Crnkl1 Bcas2 Sf3a1 Sf3a2 Upf3b Sf3b1 Sf3a3 Papola Wdr33 Rnps1 Magohb Cdc40 Srrm1 Snrnp70 Ybx1 Tfip11 Snrnp27 Cherp Elavl2 Skiv2l2 Elavl1 Pcbp1 Pcbp2 Cd2bp2 Snrnp40 UCH PROTEINASES%REACTOME DATABASE ID RELEASE 59%5689603 UCH proteinases Psmc6 Hist1h2aa Psmc5 Adrm1 Psmc2 Psmd2 Actb Psmb9 Hist1h2af Psmf1 Psmb8 Asxl2 Asxl1 Psme4 Psmc1 Psmc4 Psmc3 Psme3 Hist3h2a Yy1 Hcfc1 Hist2h2ab Bard1 Smad7 Mbd6 Uchl3 Hist2h2ac Psmd12 Ino80 Psma7 Ruvbl1 Psmd11 Kdm1b Uchl1 Psmd14 Psma5 Psmb5 Psmb4 Ubc Psmd13 Psmd10 Psma4 Psmb7 Psma3 Psma6 Psmb6 Psmb2 Psmb3 Psmb1 Psma2 Psma1 Psmd9 Ino80c Ino80b Ino80e Ino80d Nfrkb Tgfb1 Hist2h2aa1 Psmd1 Shfm1 Bap1 Psme2 Foxk1 Uchl5 Psme1 Foxk2 Nedd8 Psmd3 Psmd4 Hist1h2ak Ogt Psmb10 Psmd6 Tgfbr1 Psmd5 Hist1h2ag Senp8 Usp15 Tgfbr2 Actl6a Psmd7 Tfpt Actr8 Psmb11 Psmd8 Actr5 Hist1h2ah FGFR2 LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 59%190241 FGFR2 ligand binding and activation Fgf23 Fgf16 Fgf22 Fgf20 Fgf18 Fgf1 Fgf2 Fgf9 Fgfbp3 Fgf7 Fgf10 Fgf6 Fgfbp1 Fgf4 Fgf3 ROLE OF SECOND MESSENGERS IN NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 59%418890 Role of second messengers in netrin-1 signaling Trpc6 Trpc1 Trpc4 Ntn1 Dcc Trpc3 Trpc5 Pitpna Plcg1 Trpc7 ACTIVATION OF CASPASES THROUGH APOPTOSOME-MEDIATED CLEAVAGE%REACTOME%R-HSA-111459.2 Activation of caspases through apoptosome-mediated cleavage Casp3 Casp9 Casp7 Apaf1 LDL ENDOCYTOSIS%REACTOME%R-HSA-171052.6 LDL endocytosis Npc1 Npc2 Ap2m1 Soat1 Soat2 Lipa Ldlr Apof Ces3b Lsr Clta Ap2b1 Ap2a1 Ap2a2 Cltc Pcsk9 Nceh1 Ap2s1 Apob Ldlrap1 CLASS B 2 (SECRETIN FAMILY RECEPTORS)%REACTOME DATABASE ID RELEASE 59%373080 Class B 2 (Secretin family receptors) Gngt1 Gng7 Adcyap1r1 Gng4 Adcyap1 Gcg Crhr1 Pth2r Gngt2 Ucn Glp1r Gng10 Gcgr Crh Adm2 Calcr Iapp Wnt11 Adgre5 Wnt10a Pth1r Wnt3 Wnt10b Smo Wnt6 Wnt4 Wnt9b Wnt9a Wnt7a Wnt2b Wnt7b Wnt16 Gng11 Ptch1 Gng13 Gng12 Gnb2 Gnb1 Gnb3 Gnb5 Ghrhr Gnb4 Ghrh Wnt8a Glp2r Wnt8b Gng8 Sct Gip Ihh Wnt5a Gng3 Wnt1 Shh Gng2 Dhh Gipr Wnt2 Ramp1 Calcrl Pth Calca Ramp2 Ramp3 Pthlh Fzd6 Pth2 Adm Wnt3a Ucn3 Fzd9 Crhbp Fzd2 Fzd10 Fzd1 Fzd3 Adgre1 Fzd4 Fzd5 Fzd7 Fzd8 Ptch2 CENTROSOME MATURATION%REACTOME%R-HSA-380287.1 Centrosome maturation Pafah1b1 Ccp110 Nek2 Cep57 Akap9 Haus7 Haus8 Ppp2r1a Ywhag Ywhae Hsp90aa1 Ninl Ywhaq Cep152 Prkar2b Haus3 Haus4 Cdk1 Cetn2 Ofd1 Haus2 Cep63 Alms1 Haus5 Haus6 Haus1 Tubb4a Tubg2 Tubb4b Numa1 Clasp1 Ssna1 Tubg1 Csnk1d Cep250 Tuba4a Dynll1 Cdk11b Csnk1e Tubgcp5 Cep135 Tubgcp4 Tubgcp3 Cdk5rap2 Mapre1 Pcnt Sfi1 Cep70 Nedd1 Actr1a Cep131 Pcm1 Tubgcp2 Prkaca Dync1i2 Fgfr1op Cep76 Cep78 Cep72 Dctn2 Dctn3 Ckap5 Cep164 Tubb5 Tuba1a Cep41 Plk1 Cenpj Dync1h1 Plk4 Sdccag8 PHOSPHORYLATION OF PROTEINS INVOLVED IN G1 S TRANSITION BY ACTIVE CYCLIN E:CDK2 COMPLEXES%REACTOME%R-HSA-69200.2 Phosphorylation of proteins involved in G1 S transition by active Cyclin E:Cdk2 complexes Ccne1 Cdk2 Ccne2 Rb1 N-GLYCAN TRIMMING AND ELONGATION IN THE CIS-GOLGI%REACTOME DATABASE ID RELEASE 59%964739 N-glycan trimming and elongation in the cis-Golgi Man1c1 Man1a Manea Mgat1 Man1a2 G-PROTEIN BETA:GAMMA SIGNALLING%REACTOME DATABASE ID RELEASE 59%397795 G-protein beta:gamma signalling Gngt1 Shc1 Gng7 Gng4 Jak1 Jak2 Gngt2 Akt2 Akt3 Jak3 Gng10 Plcb1 Plcb2 Il2rg Gab2 Il5ra Il2 Pik3r6 Rhoa Pik3r5 Pik3cb Pik3cd Akt1 Il5 Pik3ca Gng11 Gng13 Gng12 Gnb2 Csf2 Gnb1 Plcb3 Pdpk1 Gnb3 Gnb5 Pik3cg Pik3r3 Gnb4 Il3ra Pik3r1 Il2ra Gng8 Il2rb Csf2rb2 Gng3 Gng2 Pik3r2 Csf2ra MRNA EDITING: A TO I CONVERSION%REACTOME%R-HSA-75064.2 mRNA Editing: A to I Conversion Adarb1 Adar RECYCLING OF EIF2:GDP%REACTOME%R-HSA-72731.2 Recycling of eIF2:GDP Eif2s1 Eif2s2 Eif2b5 Eif2b4 Eif2b3 Eif2b2 Eif2b1 Eif2s3x ABC-FAMILY PROTEINS MEDIATED TRANSPORT%REACTOME DATABASE ID RELEASE 59%382556 ABC-family proteins mediated transport Abcc9 Vcp Os9 Rnf185 Derl2 Rnf5 Sel1l Abcb1a Abcc10 Abcf1 Apoa1 Abca7 Abca12 Abca9 Abcg4 Abce1 Pex19 Psmd12 Psmd11 Psmd14 Psmd13 Psmd10 Abca3 Shfm1 Abcc1 Abcd3 Abcd2 Pex3 Abca5 Abca6 Abca2 Psmc6 Abcc6 Abcd1 Abcb4 Eif2s1 Psmc5 Eif2s2 Abcb9 Abcb5 Psmc2 Psmd2 Psmb9 Psmb8 Psmf1 Psme4 Psmc1 Psmc4 Psmc3 Psme3 Eif2s3x Abcc3 Abcc2 Abcg1 Abcg5 Abcg8 Abcc4 Rnasel Abca4 Cftr Psma7 Erlin2 Psma5 Psmb5 Abcb6 Psmb4 Ubc Abcb10 Psma4 Abcb8 Psma3 Psmb7 Psma6 Psmb6 Psmb2 Psmb3 Psma2 Psmb1 Psma1 Psmd9 Erlin1 Psmd1 Psme2 Derl1 Psme1 Derl3 Abca8b Kcnj11 Psmd3 Abcc8 Psmd4 Psmb10 Psmd6 Psmd5 Abcc5 Psmd7 Psmb11 Psmd8 Erlec1 TRANSLOCATION OF ZAP-70 TO IMMUNOLOGICAL SYNAPSE%REACTOME%R-HSA-202430.4 Translocation of ZAP-70 to Immunological synapse H2-Aa Cd3d Cd3e H2-Eb1 Lck Zap70 Cd4 Ptpn22 Cd3g ACTIVATION OF AMPA RECEPTORS%REACTOME%R-HSA-399710.1 Activation of AMPA receptors Gria2 Gria1 Gria3 Gria4 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX%REACTOME DATABASE ID RELEASE 59%201722 Formation of the beta-catenin:TCF transactivating complex Kmt2d Hist2h3c1 Hdac1 H2afj H2afb2 Crebbp Hist3h2ba Hist2h2be Ep300 Men1 Hist2h2ac H3f3b H3f3a Hist1h2bg Hist1h2bh Tert Axin2 Ctnnb1 Hist1h2bp Hist1h2bm Ruvbl1 Hist1h2bj Smarca4 Hist1h2bb Myc H2afz H2afx Cdc73 Pygo2 Tcf7l1 Pygo1 Bcl9l Tle3 Bcl9 Hist2h2aa1 Lef1 Tcf7 Kat5 Tle1 Hist1h3d Tle4 Hist1h3h Tle2 Hist1h2ak Ash2l Leo1 Hist1h2ag Rbbp5 Trrap Tcf7l2 Hist1h2ah BETA DEFENSINS%REACTOME DATABASE ID RELEASE 59%1461957 Beta defensins Defb47 Defb15 Tlr2 Defb19 Defb14 Defb23 Defb12 Defb25 Ccr6 Tlr1 Defb18 Gm15386 Defb36 Ccr2 Defb29 SHC-MEDIATED CASCADE:FGFR2%REACTOME DATABASE ID RELEASE 59%5654699 SHC-mediated cascade:FGFR2 Fgf23 Fgf16 Fgf22 Kras Fgf20 Nras Fgf18 Hras Sos1 Fgf1 Fgf2 Fgf9 Fgf7 Fgf6 Fgf10 Fgf4 Fgf3 SIGNALING BY PLASMA MEMBRANE FGFR1 FUSIONS%REACTOME DATABASE ID RELEASE 59%8853336 Signaling by plasma membrane FGFR1 fusions Fgfr1 Bag4 Erlin2 NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME%R-HSA-181430.2 Norepinephrine Neurotransmitter Release Cycle Snap25 Ppfia2 Ppfia1 Ppfia4 Unc13b Rab3a Syt1 Slc22a2 Slc18a2 Vamp2 Slc22a1 Cplx1 Maoa Stx1a PURINE SALVAGE%REACTOME DATABASE ID RELEASE 59%74217 Purine salvage Adal Ampd1 Hprt Gmpr Aprt Pnp Ada Ampd2 Ampd3 Dck Adk Dguok Gmpr2 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10%REACTOME%R-HSA-933543.1 NF-kB activation through FADD RIP-1 pathway mediated by caspase-8 and -10 Mavs Casp8 Fadd Rnf135 Chuk Ifih1 Ripk1 Ikbkb Ddx58 Ikbkg Trim25 TRYPTOPHAN CATABOLISM%REACTOME DATABASE ID RELEASE 59%71240 Tryptophan catabolism Slc3a2 Kmo Tdo2 Afmid Acmsd Ido2 Ido1 Slc7a5 Haao Ccbl1 Kynu Aadat Ccbl2 MITOCHONDRIAL TRANSLATION ELONGATION%REACTOME%R-HSA-5389840.1 Mitochondrial translation elongation Mrps14 Mrps11 Mrps16 Mrpl41 Mrps9 Mrps15 Mrpl28 Mrps17 Mrpl35 Dap3 Gadd45gip1 Mrps10 Eral1 Mrps12 Mrpl40 Mrpl38 Mrps5 Mrpl39 Mrps2 Mrpl32 Mrpl33 Mrpl34 Mrpl36 Mrps6 Mrpl37 Mrps7 Mrps34 Mrpl20 Mrps31 Mrps30 Mrpl1 Mrpl16 Mrpl2 Mrpl17 Mrpl14 Mrpl3 Mrpl4 Mrpl12 Mrpl13 Mrpl10 Mrpl11 Mrpl9 Mrpl55 Mrpl57 Mrpl19 Mrpl18 Chchd1 Mrpl54 Mrpl30 Ptcd3 Mrps18a Mrpl22 Mrpl21 Mrps18b Mrps18c Mrpl24 Mrpl51 Mrps23 Mrps22 Mrpl50 Mrps25 Mrpl53 Mrps24 Mrpl52 Mrps28 Aurkaip1 Mrps26 Mrps27 Tsfm Mrps21 Mrpl47 Mrpl48 Gfm1 Ict1 Mrpl46 Mrpl43 Mrpl44 Mrpl49 Tufm Mrps33 Mrps35 Mrpl45 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS%REACTOME DATABASE ID RELEASE 59%174143 APC C-mediated degradation of cell cycle proteins Psmc6 Psmc5 Nek2 Psmc2 Psmd2 Psmb9 Psmf1 Psmb8 Btrc Psme4 Cdk2 Cdk1 Skp1a Psmc1 Ccna1 Psmc4 Skp2 Psmc3 Cul1 Ccna2 Psme3 Anapc15 Anapc11 Anapc10 Fzr1 Fbxo5 Aurkb Aurka Pttg1 Bub1b Psmd12 Plk1 Psma7 Psmd11 Psmd14 Psma5 Psmb5 Psmb4 Ubc Psmd13 Bub3 Psmd10 Psma4 Psmb7 Psma3 Psma6 Psmb6 Psmb2 Mad2l1 Psmb3 Psmb1 Psma2 Psma1 Cdc23 Psmd9 Ube2d1 Cdc27 Cdc14a Cdc16 Cdc20 Ube2c Anapc16 Ube2e1 Anapc7 Psmd1 Shfm1 Anapc4 Psme2 Anapc5 Anapc1 Psme1 Anapc2 Psmd3 Psmd4 Psmb10 Psmd6 Psmd5 Psmd7 Psmb11 Psmd8 EICOSANOID LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 59%391903 Eicosanoid ligand-binding receptors Cysltr1 Tbxa2r Ptgir Ptgdr2 Ltb4r2 Ptger3 Ptger4 Ltb4r1 Gpr17 Ptger1 Ptger2 Ptgdr Cysltr2 Ptgfr REGULATION OF TP53 ACTIVITY%REACTOME DATABASE ID RELEASE 59%5633007 Regulation of TP53 Activity Trp53rkb Nuak1 Prkaa2 Trp53inp1 Ppp2r1a Mlst8 Brpf3 Rffl Trex1 Rfc5 Taf1 Mdm4 Taf2 Brpf1 Rfc3 Ing5 Mtor Hdac1 Rnf34 Rfc2 Ing2 Prkaa1 Taf4b Taf7 Taf4a Rfc4 Taf5 Taf6 Taf3 Hdac2 Nbn Map2k6 Atrip Dna2 Bard1 Aurkb Taf9 Aurka Chek2 Rpa2 Mre11a Rpa1 Atm Ep300 Rpa3 Banp Rad17 Taf13 Taf11 Csnk2a2 Tpx2 Pml Plk3 Rbbp8 Rbbp7 Rad1 Ccng1 Setd8 Trp73 Taf12 Cdk5r1 Ppp2r1b Hipk1 Hipk2 Kat5 Gatad2a Gatad2b Csnk2b Mdm2 Tmem55b Pou4f1 Pou4f2 Cdk5 Meaf6 Prkag2 Prkag1 Prkag3 Trp53bp2 Kat6a Brd7 Ppp1r13b Mapkapk5 Mapkap1 Ppp1r13l Cdk2 Cdk1 Ppp2r5c Pin1 Rad50 Ccna1 Rbbp4 Chd3 Chd4 Ccna2 Ttc5 Smyd2 Tbp Phf20 Trp63 Taf9b Mbd3 Ssrp1 Usp7 Top3a L3mbtl1 Prr5 Ppp2cb Chek1 Ppp2ca Akt2 Sgk1 Akt3 Topbp1 Dyrk2 Mta2 Rad9a Blm Ubc Rad9b Usp2 Hus1 Prmt5 Cdkn2a Prdm1 Prkab1 Exo1 Brip1 Zfp385a Akt1 Stk11 Pip4k2b Pip4k2a Trp53 Prkab2 Pip4k2c Ak6 Wrn Supt16 Jmy Mapk11 Brca1 Ehmt2 Rictor Mapk14 Pdpk1 Daxx Ehmt1 CLEARANCE OF SERATONIN%REACTOME DATABASE ID RELEASE 59%380615 Clearance of seratonin Aldh2 Slc6a4 Maoa MINERALOCORTICOID BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 59%193993 Mineralocorticoid biosynthesis Lhb Cyp21a1 Hsd3b1 Hsd3b6 Cyp11b2 Cga VOLTAGE GATED POTASSIUM CHANNELS%REACTOME%R-HSA-1296072.1 Voltage gated Potassium channels Kcnh2 Kcna1 Kcnq1 Kcnq3 Kcna3 Kcna2 Kcna4 Kcnh1 Kcna5 Kcnc1 Kcnq2 Kcnb1 Kcnab2 Kcns3 Kcng2 Kcnc2 Kcnd3 Kcna6 Kcnd2 Kcnd1 Kcnv2 Kcnv1 Kcna10 Kcnh8 Kcnf1 Kcnh7 Kcnh6 Kcnq5 Kcns1 Kcng4 Kcng1 Kcna7 Kcng3 Kcnc4 Kcnc3 Kcnh4 Kcnh5 Kcnab3 Kcnh3 Kcnab1 Kcnb2 Kcnq4 Kcns2 DEFECTIVE PRO-SFTPB CAUSES PULMONARY SURFACTANT METABOLISM DYSFUNCTION 1 (SMDP1) AND RESPIRATORY DISTRESS SYNDROME (RDS)%REACTOME%R-HSA-5688031.1 Defective pro-SFTPB causes pulmonary surfactant metabolism dysfunction 1 (SMDP1) and respiratory distress syndrome (RDS) Ccdc59 Ttf1 Sftpb RNA POLYMERASE II HIV PROMOTER ESCAPE%REACTOME%R-HSA-167162.2 RNA Polymerase II HIV Promoter Escape Gtf2h5 Gtf2a1 Taf13 Gtf2h4 Taf11 Gtf2a2 Gtf2b Gtf2h3 Ercc3 Taf1 Taf2 Taf4b Taf7 Taf4a Taf12 Taf5 Taf6 Taf3 Ercc2 Polr2i Polr2f Polr2j Polr2e Gtf2e1 Polr2h Tbp Gtf2e2 Polr2c Mnat1 Polr2d Ak6 Polr2b Taf9b Taf9 Polr2k Polr2g Ccnh Cdk7 Polr2a Gtf2h1 Gtf2f1 Gtf2h2 Gtf2f2 TRANSPORT OF ORGANIC ANIONS%REACTOME DATABASE ID RELEASE 59%879518 Transport of organic anions Slco4a1 Alb Slc16a2 Avp Slco1c1 Slco2a1 Slco1a4 Slco2b1 Slco4c1 Slco1b2 HDR THROUGH HOMOLOGOUS RECOMBINATION (HRR)%REACTOME%R-HSA-5685942.1 HDR through Homologous Recombination (HRR) Polh Pcna Polk Trex1 Rfc5 Eme1 Rfc3 Rfc2 Rad50 Rad51b Rad51c Gen1 Rfc4 Rfc1 Nbn Pole Atrip Dna2 Pold1 Pold2 Bard1 Pold3 Pold4 Pole2 Rpa2 Rpa1 Mre11a Atm Rpa3 Top3a Rtel1 Rad17 Pole4 Brca2 Pole3 Chek1 Rbbp8 Topbp1 Rad9a Blm Rad1 Ubc Rad9b Hus1 Exo1 Brip1 Rad51 Spidr Rad51ap1 Kat5 Slx4 Wrn Mus81 Brca1 Palb2 Xrcc3 Rad51d Xrcc2 FRS-MEDIATED FGFR3 SIGNALING%REACTOME DATABASE ID RELEASE 59%5654706 FRS-mediated FGFR3 signaling Fgf23 Fgf16 Kras Fgf20 Frs2 Nras Fgf18 Frs3 Hras Sos1 Fgf1 Fgf2 Fgf9 Ptpn11 Fgf4 RAF-INDEPENDENT MAPK1 3 ACTIVATION%REACTOME DATABASE ID RELEASE 59%112409 RAF-independent MAPK1 3 activation Il6ra Dusp16 Dusp7 Dusp10 Map2k1 Jak1 Dusp6 Jak2 Dusp9 Pea15a Map2k2 Dusp8 Tyk2 Dusp1 Il6 Cdk1 Dusp2 Dusp5 Mapk3 Ptpn11 Mapk1 Dusp4 SIGNALING BY NODAL%REACTOME%R-HSA-1181150.1 Signaling by NODAL Lefty2 Pcsk6 Smad4 Smad2 Smad3 Acvr1b Furin Nodal Drap1 Dand5 Foxh1 Acvr2b Acvr2a Foxo3 Acvr1c Lefty1 Cer1 PLATELET ACTIVATION, SIGNALING AND AGGREGATION%REACTOME DATABASE ID RELEASE 59%76002 Platelet activation, signaling and aggregation Thpo G6b Trpc6 Gp1bb Gp1ba Pdpn Serpine1 Tgfb3 Clec1b Tgfb2 Gp5 Mpl Gp9 Prkcb Gp6 Pfn1 Lat App Rac1 Actn1 Actn4 Csf2 Trpc3 Apoa1 Trpc7 Daglb Jak1 Timp1 Stx4a Dagla Vegfa Mgll Aldoa Trf Vav2 Gnat3 Cd36 F13a1 Pros1 F2rl3 F2rl2 Pf4 Raf1 Rapgef4 Il5ra Rapgef3 Csk Pla2g4a Ptk2 Gna11 Gna12 F2r Rhog Gnaq Gna15 Rhob F2 Gna13 Gna14 Ptpn1 Shc1 Igf2 Akt2 Igf1 P2ry12 Akt3 Gab2 Adra2a Adra2c Adra2b Mapk3 Akt1 Mapk1 Ppia Kng2 Ppbp Sos1 Apbb1ip Pik3cg Vegfb Vegfc Figf Csf2rb2 Csf2ra Lcp2 Prkcd Prkce Actn2 Prkcg Plg Brpf3 Prkca Dgkb Vav1 Il2rg Arrb2 Dgka Arrb1 Rhoa Vwf Dgke Dgkg Sytl4 Fermt3 Apoh Wdr1 Serping1 Srgn Gas6 Serpinf2 F5 F8 Fam49b Cyb5r1 Maged2 A1bg Lgals3bp Nhlrc2 Pcyox1l Calu Rasgrp2 Endod1 Fam3c Lhfpl2 Manf Chid1 Aplp2 Habp4 Pcdh7 Apool Cdc37l1 Serpina3n Tor4a Islr Fgg Pdgfb Lyn Prkcq Il2 Il5 Prkch P2ry1 Serpina1d Serpina1a Itpr1 Lck Rac2 Ptpn6 Il3ra Il2ra Il2rb Itpr3 Ptpn11 Itpr2 Gngt1 Gng7 Egf Abhd12 Gng4 Tbxa2r Gngt2 Gng10 Stxbp3 Pik3r6 Pik3r5 Pik3cb Pik3cd Itgb3 Gnai2 Fyn Gnai1 Gnai3 Plcg2 Tuba4a Syk Rasgrp1 Tln1 Gng11 Pik3ca Gng13 Gng12 Gnb2 Gnb1 A2m Gnb3 Gnb5 Fga Gnb4 Fgb Thbs1 Gng8 Vav3 Gng3 Hgf Gng2 Tex264 Psap Ahsg Alb Abcc4 Ywhaz Cfd Fcer1g Cap1 Jak2 Dgkq Ola1 Clec3b Itga2b Ctsw Rap1a Rab27b Jak3 Hrg Selp Cd109 Dgkh Rap1b Scg3 Hspa5 Stxbp2 Flna Lamp2 Dgki Sccpdh Phactr2 Sepp1 Gtpbp2 Clu Tagln2 Tmx3 Timp3 Pecam1 Vcl Ttn Spp2 Orm3 Cd9 Plek Vti1b Qsox1 Ecm1 Mmrn1 Lefty2 Anxa5 Itih3 Tgfb1 Rarres2 Cd63 Itih4 Abhd6 Prkcz Fn1 Bcar1 Sparc Mapk14 Pdpk1 Pik3r3 Dgkz Crk Pik3r1 Pik3r2 FATTY ACIDS%REACTOME DATABASE ID RELEASE 59%211935 Fatty acids Cyp4a12b Cyp2j6 Cyp2f2 Cyp2b10 Cyp4f18 Cyp4f17 Cyp4f15 Cyp4b1 Cyp2a5 Cyp2d22 Cyp4f40 Cyp4a32 Cyp4f14 Cyp4f39 THE RETINOID CYCLE IN CONES (DAYLIGHT VISION)%REACTOME%R-HSA-2187335.1 The retinoid cycle in cones (daylight vision) Opn1sw Rbp3 Opn1mw Rlbp1 Dhrs3 ATF6 (ATF6-ALPHA) ACTIVATES CHAPERONES%REACTOME%R-HSA-381033.2 ATF6 (ATF6-alpha) activates chaperones Ddit3 Hsp90b1 Nfyb Nfyc Mbtps1 Calr Mbtps2 Atf6 Hspa5 Atf4 Nfya ACTIVATION AND OLIGOMERIZATION OF BAK PROTEIN%REACTOME DATABASE ID RELEASE 59%111452 Activation and oligomerization of BAK protein Bak1 Bid SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR3%REACTOME DATABASE ID RELEASE 59%1839130 Signaling by activated point mutants of FGFR3 Fgf1 Fgf23 Fgf16 Fgf2 Fgf20 Fgf18 Fgf9 Fgfr3 Fgf4 KERATINIZATION%REACTOME%R-HSA-6805567.2 Keratinization Perp Krt1 Ppl Krt72 Krt79 Gm11937 Krt73 Krtap15 Krt77 Krt78 Krtap24-1 Lce3b Lor Krt76 Gm11563 Krtap1-4 Krtap4-16 Krtap1-3 Krt40 Tgm5 Krtap19-4 Krtap17-1 Tgm1 Lce1m Krtap13-1 Dsg1a Dsg3 Dsp Dsg2 Krtap16-3 Krt10 Krt12 Krt13 Rptn Krtap26-1 Sprr1b Pkp1 Krt18 Krt15 Krt14 Krt17 Krt16 Krtap12-1 Cela2a Krt9 Krtap4-7 Krt7 Krt5 Krt2 Krt8 St14 Krt4 Klk8 Evpl Klk5 Dsg4 Spink5 Krt6a Krtap4-2 Prss8 Krt75 Krt71 Krt84 Krt86 Krt80 Krt82 Pkp3 Pkp2 2010005H15Rik Krt83 Tchh Krt39 Pkp4 Sprr2k Dsc2 2310034C09Rik Krtap3-2 Krtap3-1 Krt35 Krt34 Dsc3 Gm11596 Capn1 Kazn Cdsn Krt32 Capns1 Krt31 Krt27 4930553J12Rik Krt25 Krt26 Klk12 Krt33a Krtap9-5 Krt24 Krt23 Krt33b Casp14 Klk14 Krt20 Furin Jup Klk13 Dsc1 Pcsk6 PPARA ACTIVATES GENE EXPRESSION%REACTOME DATABASE ID RELEASE 59%1989781 PPARA activates gene expression Nfyb Nfyc Cyp7a1 Helz2 Mtf1 Srebf2 Cdk8 Nr1h4 Nrf1 Thrap3 Nfya Arntl Apoa2 Cyp4a32 Acsl1 Ahr Grhl1 Fhl2 Acadm Ep300 Apoa1 Ncoa3 Txnrd1 Med20 Med31 Glipr1 Med1 Nr1d1 Med27 Tbl1x Med26 Med30 Sult2a1 Agt Med23 Med24 Med25 Ctgf Cyp1a1 Med4 Arnt2 Med8 Med6 Havcr2 Fdft1 Med9 Rxra Carm1 Ugt1a9 Cd36 Ahrr Tbl1xr1 Trib3 Abcb4 Fads1 Cdk19 Ccnc Tead3 Med13 Fam120b Med14 Tead1 Med12 Tead2 Sp1 Med10 Rgl1 Arnt Chd9 Clock Med16 Med17 Alas1 Med15 Tnfrsf21 Abca1 Esrra Rora Ncor1 Fabp1 Slc27a1 Crebbp Med13l Cpt2 Cpt1a Smarcd3 G0s2 Med22 Med28 Med29 Ppara Med21 Pparg Med11 Yap1 Me1 Med19 Ppargc1b Ankrd1 Ppargc1a Wwtr1 Apoa5 Tiam2 Hmgcs2 Plin2 Tead4 Med18 Ncoa1 Pex11a Npas2 Angptl4 Ncoa6 Ncoa2 Hdac3 SIGNALING BY WNT%REACTOME%R-HSA-195721.3 Signaling by Wnt Dvl1 Dvl3 Ppp2r1a Xpo1 Prkcb Dvl2 Btrc Pfn1 H2afj H2afb2 Wnt11 Map3k7 Wnt10a Wnt3 Wnt10b Wnt6 Ppp3cb Wnt4 Rac1 Wnt9b Wnt9a Vps26a Wls Ppp3ca Tmed5 Wnt7a Wnt2b Ppp3r1 Wnt7b Nfatc1 Wnt16 Hist2h2be Ep300 Wnt8a Wnt8b Wnt5b Hist2h2ac Vps29 Pard6a Wnt5a Wnt1 H3f3b Vps35 H3f3a Wnt2 Hist1h2bg Hist1h2bh Ap2m1 Tert Csnk2a2 Hist1h2bp Hist1h2bm Rnf146 Daam1 Ruvbl1 Hist1h2bj Xiap Hist1h2bb Ap2a1 Ap2a2 Ap2s1 Ctbp1 Pygo2 Frat2 Pygo1 Tcf7l1 Tle3 Bcl9l Porcn Ctbp2 Bcl9 Aes Dkk1 Tnks Fzd6 Lef1 Dkk2 Tcf7 Gnat2 Hist1h3d Tle1 Clta Tle4 Ap2b1 Csnk2b Tle2 Wnt3a Tnks2 Kremen2 Cltc Hist1h2ak Kremen1 Fzd2 Hist1h2ag Fzd1 Fzd3 Dkk4 Trrap Fzd4 Fzd7 Fzd5 Fzd8 Lrp6 Tcf7l2 Hist1h2ah Lrp5 Rnf43 Psmf1 Psme4 Hist2h3c1 Skp1a Cul1 Psme3 Ppp2cb Ppp2ca Akt2 Psma7 Plcb1 Plcb2 Psmb5 Psmb4 Ubc Myc Psmb7 Psmb6 Psmb2 Psmb3 Psmb1 Akt1 Psme2 Csnk1g2 Hist1h3h Psme1 Psmb10 Plcb3 Smurf2 Psmb11 Mov10 Scrib Sost Ccdc88c Vangl2 Dact1 Nlk Sox13 Prkcg Cby1 Ror1 Ror2 Cxxc4 Chd8 Prkca Usp8 Znrf3 Arrb2 Rspo2 Lgr4 Rspo4 Hdac1 Rspo3 Rhoa Lgr6 Rspo1 Lgr5 Sox2 Sox7 Pde6a Sox6 Wif1 Sox9 Pde6b Hecw1 Sox4 Sox3 Prickle1 Men1 Prkg1 Sox17 Ctnnbip1 Klhl12 Ryk Sfrp2 Sfrp1 Cltb Pde6g Apc Rbx1 Axin1 Amer1 Csnk1a1 Ctnnb1 Cul3 Psmd12 Psmd11 Smarca4 Psmd14 Psmd13 Psmd10 Cdc73 Ppp2r1b Ago2 Ago1 Tnrc6c Kat5 Gsk3b Tnrc6b Shfm1 Tnrc6a Ago4 Ago3 Itpr1 Rac2 Leo1 Itpr3 Itpr2 Gngt1 Psmc6 Gng7 Gng4 Psmc5 Gngt2 Psmc2 Psmd2 Gng10 Psmb9 Psmb8 Kmt2d Ppp2r5e Ppp2r5c Ppp2r5d Ppp2r5a Psmc1 Psmc4 Psmc3 Prkg2 Cav1 Ppp2r5b Csnk1e Gng11 Gng13 Crebbp Gng12 Gnb2 Gnb1 Gnb3 Hist3h2ba Gnb5 Gnb4 Gng8 Gng3 Gng2 Ywhaz Axin2 Camk2a Psma5 Rac3 Psma4 Psma3 Psma6 H2afz H2afx Psma2 Psma1 Pip5k1b Psmd9 Hist2h2aa1 Smurf1 Psmd1 Snx3 Gnao1 Psmd3 Psmd4 Psmd6 Psmd5 Ash2l Rbbp5 Psmd7 Psmd8 LGI-ADAM INTERACTIONS%REACTOME%R-HSA-5682910.2 LGI-ADAM interactions Cacng8 Cacng4 Cacng3 Cacng2 Lgi2 Lgi1 Adam22 Adam11 Dlg4 Stx1b Adam23 Lgi4 Lgi3 Stx1a RNF MUTANTS SHOW ENHANCED WNT SIGNALING AND PROLIFERATION%REACTOME DATABASE ID RELEASE 59%5340588 RNF mutants show enhanced WNT signaling and proliferation Wnt3a Fzd6 Fzd4 Fzd5 Fzd8 Lrp6 Lrp5 Rnf43 TOXICITY OF BOTULINUM TOXIN TYPE F (BONT F)%REACTOME%R-HSA-5250981.1 Toxicity of botulinum toxin type F (BoNT F) Sv2c Vamp1 Sv2b Sv2a Vamp2 BETA-CATENIN PHOSPHORYLATION CASCADE%REACTOME DATABASE ID RELEASE 59%196299 Beta-catenin phosphorylation cascade Ppp2cb Frat2 Ppp2r1b Apc Axin1 Ppp2ca Amer1 Csnk1a1 Ctnnb1 Gsk3b Ppp2r1a Ppp2r5b Ppp2r5e Ppp2r5c Ppp2r5d Ppp2r5a PROCESSING AND ACTIVATION OF SUMO%REACTOME%R-HSA-3215018.1 Processing and activation of SUMO Senp1 Senp2 Sumo3 Sae1 Uba2 Ube2i Senp5 SIGNALING BY BMP%REACTOME%R-HSA-201451.3 Signaling by BMP Smad5 Ski Ube2d1 Zfyve16 Nog Smad6 Smad9 Bmpr2 Grem2 Fstl1 Smurf1 Smad4 Smad7 Bmpr1a Bmpr1b Ube2d3 Smad1 Bmp2 Acvr2b Acvr2a Smurf2 Cer1 PROTON-COUPLED MONOCARBOXYLATE TRANSPORT%REACTOME DATABASE ID RELEASE 59%433692 Proton-coupled monocarboxylate transport Emb Slc16a3 Slc16a1 Bsg Slc16a8 Slc16a7 DEFECTS IN BIOTIN (BTN) METABOLISM%REACTOME%R-HSA-3323169.1 Defects in biotin (Btn) metabolism Mccc2 Mccc1 Pcca Pcx Acaca Pccb PHOSPHATE BOND HYDROLYSIS BY NUDT PROTEINS%REACTOME DATABASE ID RELEASE 59%2393930 Phosphate bond hydrolysis by NUDT proteins Nudt15 Nudt5 Adprm Nudt16 O-GLYCOSYLATION OF TSR DOMAIN-CONTAINING PROTEINS%REACTOME DATABASE ID RELEASE 59%5173214 O-glycosylation of TSR domain-containing proteins Adamts12 Thsd4 Adamts19 Thsd1 Adamts10 Sspo Adamts20 B3glct Pofut2 Cfp Adamtsl3 Adamtsl4 Adamts4 Adamtsl1 Adamts13 Adamts1 Adamtsl2 Adamts14 Sbspon Adamts15 Sema5a Spon2 Thsd7a Adamts8 Adamts5 Adamtsl5 Spon1 Adamts3 Adamts18 Adamts6 Adamts16 Adamts7 Adamts2 Thbs1 Thsd7b Sema5b Thbs2 XBP1(S) ACTIVATES CHAPERONE GENES%REACTOME DATABASE ID RELEASE 59%381038 XBP1(S) activates chaperone genes Arfgap1 Edem1 Syvn1 Gosr2 Preb Ppp2r5b Tln1 Sec63 Klhdc3 Sec62 Yif1a Lmna Zbtb17 Cul7 Serp1 Shc1 Sec61a2 Sec31a Wipi1 Acadvl Extl3 Tspyl2 Sec61g Hdgf Sec61a1 Sec61b Gfpt1 Asna1 Add1 Srprb Pdia6 Ssr1 Tpp1 Pdia5 Mydgf Wfs1 Dnajb9 Atp6v0d1 Dnajb11 Tatdn2 Cxxc1 Fkbp14 Ddx11 Srpr Dnajc3 Dctn1 Gsk3a Hyou1 Kdelr3 VITAMIN B1 (THIAMIN) METABOLISM%REACTOME DATABASE ID RELEASE 59%196819 Vitamin B1 (thiamin) metabolism Slc19a2 Slc25a19 Tpk1 Thtpa DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME DATABASE ID RELEASE 59%3359463 Defective CUBN causes hereditary megaloblastic anemia 1 Amn Cubn Gif ARACHIDONIC ACID METABOLISM%REACTOME DATABASE ID RELEASE 59%2142753 Arachidonic acid metabolism Alox12b Ptges2 Cyp2u1 Lta4h Ptgr2 Ptgr1 Ggt1 Dpep1 Dpep2 Cbr1 Ephx2 Dpep3 Cyp4f18 Awat1 Cyp4f17 Alox5 Akr1c18 Cyp4f15 Pon2 Cyp4b1 Pon1 Gpx1 Tbxas1 Pla2g4a Hpgds Cyp4a32 Cyp4f39 Mapkapk2 Cyp2j6 Alox8 Alox15 Gpx4 Hpgd Gpx2 Alox5ap Cyp4a12b Cyp1a2 Ltc4s Ptgis Ptgs1 Ptgs2 Cyp1a1 Ptgds Ptges Cyp8b1 Faah Ggt5 Fam213b Cyp2c65 Cyp1b1 Pon3 Abcc1 Alox12 Cyp4f40 Cyp2c50 DISEASES OF SIGNAL TRANSDUCTION%REACTOME%R-HSA-5663202.4 Diseases of signal transduction Vcp Hdac4 Hdac5 Akap9 Ppp2r1a Cdk8 Hdac2 Smad4 Smad2 Smad3 Mib2 Hdac10 Neurl1a Neurl1b Hey1 Hdac11 Hey2 Ep300 Hdac7 Hdac6 Hdac9 Hdac8 Hes5 Lmna Mib1 Heyl Hes1 Cd86 Tbl1x Atg7 Cd80 Stat3 Ctbp1 Porcn Ctbp2 Dkk1 Tnks Fzd6 Dkk2 Wnt3a Tnks2 Kremen2 Kremen1 Dkk4 Fzd4 Fzd5 Fzd8 Lrp6 Tcf7l2 Lrp5 Rnf43 Frs2 Nras Agtrap Qk Clcn6 Psmf1 Raf1 Psme4 Fam131b Ap3b1 Fgf1 Snd1 Bad Aggf1 Notch1 Trak1 Fgf2 Skp1a Kdm7a Cnksr1 Csk Fxr1 Cnksr2 D630045J12Rik Erbb2 Mprip Fgf9 Fgf7 Cul1 Fam114a2 Psme3 Fgf6 Papd7 Fgf4 Agk Fgf3 Zc3hav1 Ncor1 Ncor2 Opn1sw Fgfr2 Ppp2cb Shc1 Adam10 Chuk Napepld Nrg2 Ppp2ca Bcr Nrg1 Akt2 Fgfr1 Akt3 Myo18a Rlbp1 Trim24 Psma7 Fgfr3 Bag4 Stra6 Cux1 Plcg1 Erlin2 Brap Fgfr1op2 Psmb5 Gab2 Psmb4 Cpsf6 Zmym2 Ubc Nrg3 Myc Psmb7 Nrg4 Psmb6 Psmb2 Psmb3 Psmb1 Mapk3 Akt1 Mapk1 Ksr1 Map3k11 Pik3ap1 Psme2 Psme1 Sos1 Rictor Braf Psmb10 Apbb1ip Tgfbr1 Fkbp1a Tgfbr2 Adam17 Psmb11 Jag2 Dll1 Dll4 Erlec1 Jag1 Casp9 Nf1 Tsc2 Os9 Pdgfrb Stat5b Pdgfra Derl2 Stat5a Mlst8 Vav1 Arrb2 Egfr Gab1 Arrb1 Mtor Syvn1 Hdac1 Sel1l Vwf Maml2 Aph1b Polr2i Maml1 Polr2j Polr2c Polr2d Polr2b Polr2g Polr2a Gtf2f1 Ihh Kat2b Ncbp1 Shh Kat2a Ncbp2 Dhh Gtf2f2 Map2k1 Apc Rbx1 Axin1 Amer1 Fgg Csnk1a1 Cdkn1a Ctnnb1 Map2k2 Psmd12 Pdgfb Psmd11 Ttr Psmd14 Rasa3 Rasa4 Psmd13 Cbl Psmd10 Rasa2 Rasa1 Kit Ppp2r1b Ywhab Rbp1 Kras Rbp4 Gsk3a Gsk3b Opn1mw Shfm1 Trat1 Irs2 Mdm2 Lck Syngap1 Hbegf Irs1 Btc Ptpn11 Tbl1xr1 Psmc6 Egf Fgf23 Psmc5 Fgf22 Mark3 Psmc2 Fgf20 Psmd2 Dab2ip Ccnc Psmb9 Hsp90aa1 Cdc37 Psmb8 Araf Hras Ppp2r5e Mapkap1 Ppp2r5c Rps6kb2 Ppp2r5d Ppp2r5a Psmc1 Psmc4 Psmc3 Pik3cb Foxo3 Pik3cd Foxo1 Itgb3 Fyn Polr2f Creb1 Polr2e Phb Polr2h Stat1 Pebp1 Ppp2r5b Tln1 Polr2k Pik3ca Crebbp Cdkn1b Fga Fgb Fgfr1op Nr4a1 Rbpj Prr5 Hgf Papss1 Ereg Jak2 Itga2b Rap1a Maml3 Rap1b Fgfr4 Psma5 Rasal3 Rasal2 Psma4 Psma3 Psma6 Akt1s1 Vcl Psma2 Psma1 Cd19 Psmd9 Iqgap1 Fgf16 Tgfb1 Fgf15 Psen2 Klb Fgf18 Ncstn Psmd1 Met Fn1 Bcl2l11 Rasal1 Psmd3 Psmd4 Pdpk1 Psmd6 Psmd5 Mamld1 Pik3r3 Psmd7 Pik3r1 Psmd8 Fgf10 Pik3r2 Hdac3 HIGHLY CALCIUM PERMEABLE NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%R-HSA-629597.1 Highly calcium permeable nicotinic acetylcholine receptors Chrnb2 Chrna4 Chrna5 Chrnb4 Chrnb3 Chrna3 Chrna1 Chrna6 Chrna2 HIV TRANSCRIPTION ELONGATION%REACTOME DATABASE ID RELEASE 59%167169 HIV Transcription Elongation Gtf2h5 Gtf2h4 Cdk9 Gtf2h3 Ercc3 Ercc2 Polr2i Polr2f Polr2j Polr2e Nelfa Polr2h Nelfb Ell Polr2c Mnat1 Polr2d Supt4a Tcea1 Polr2b Tceb1 Tceb3 Supt16 Polr2k Polr2g Ccnt1 Ctdp1 Ssrp1 Ccnh Cdk7 Polr2a Nelfe Supt5 Nelfcd Gtf2h1 Gtf2f1 Ncbp1 Ncbp2 Gtf2h2 Gtf2f2 ERBB2 REGULATES CELL MOTILITY%REACTOME%R-HSA-6785631.3 ERBB2 Regulates Cell Motility Memo1 Diap1 Egf Ereg Nrg2 Nrg1 Egfr Nrg3 Nrg4 Hbegf Erbb2 Rhoa Btc PHOSPHOLIPASE C-MEDIATED CASCADE; FGFR2%REACTOME DATABASE ID RELEASE 59%5654221 Phospholipase C-mediated cascade; FGFR2 Fgf23 Fgf16 Fgf22 Fgf20 Fgf18 Plcg1 Fgf1 Fgf2 Fgf9 Fgf7 Fgf10 Fgf6 Fgf4 Fgf3 VRNP ASSEMBLY%REACTOME DATABASE ID RELEASE 59%192905 vRNP Assembly Ipo5 Hsp90aa1 RRNA PROCESSING IN THE MITOCHONDRION%REACTOME%R-HSA-8868766.2 rRNA processing in the mitochondrion 1110008L16Rik Ftsj2 Rnmtl1 Nsun4 Elac2 Tfb1m Trmt10c Hsd17b10 Mterf4 Mrm1 DECTIN-1 MEDIATED NONCANONICAL NF-KB SIGNALING%REACTOME%R-HSA-5607761.1 Dectin-1 mediated noncanonical NF-kB signaling Psmc6 Psmc5 Psmc2 Psmd2 Psmb9 Psmb8 Psmf1 Psme4 Btrc Nfkb2 Fbxw11 Skp1a Psmc1 Psmc4 Psmc3 Cul1 Psme3 Rela Chuk Uba3 Psmd12 Psma7 Psmd11 Map3k14 Relb Psmd14 Psma5 Psmb5 Psmb4 Psmd13 Ubc Psmd10 Psma4 Psma3 Psmb7 Psma6 Psmb6 Psmb2 Psmb3 Ube2m Psma2 Psmb1 Psma1 Psmd9 Psmd1 Shfm1 Psme2 Psme1 Psmd3 Psmd4 Psmb10 Psmd6 Psmd5 Psmd7 Psmb11 Psmd8 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 59%438066 Unblocking of NMDA receptor, glutamate binding and activation Actn2 Gria2 Grin2c Akap9 Camk2d Gria3 Camk2a Gria4 Camk2b Grin1 Dlg4 Gria1 Nefl Grin2d Camk2g Grin2b Grin2a BETA-OXIDATION OF PRISTANOYL-COA%REACTOME%R-HSA-389887.2 Beta-oxidation of pristanoyl-CoA Acoxl Amacr Acox2 Nudt19 Hsd17b4 Crot Crat Acot8 Acox3 CELLULAR SENESCENCE%REACTOME%R-HSA-2559583.1 Cellular Senescence Suz12 Hmga2 Lmnb1 Ep400 Hmga1 Cabin1 Hist1h1d H1f0 Ubn1 Rb1 Cdkn2c Ccne1 Mapk9 Mdm4 Nfkb1 Ccne2 Mapkapk3 Rnf2 H2afj Mapk10 Cdk6 H2afb2 Mapkapk2 Nbn Map2k6 Mapk8 Jun Map2k7 Map2k3 Map2k4 Rela Il6 Mre11a Atm Hist2h2be Hist2h2ac H3f3b H3f3a Hist1h2bg Tinf2 Hist1h2bh Pot1a Cdkn1a Terf1 Terf2 Hist1h2bp Hist1h2bm Acd Hist1h2bj Ezh2 Hist1h2bb Rbbp7 Stat3 Terf2ip Ifnb1 Il1a Cdc23 Ube2d1 Rps6ka3 Ago1 Cdc27 Phc3 Rps6ka2 Rps6ka1 Tnrc6c Cdc16 Kat5 Ube2c Anapc16 Tnrc6b Ube2e1 Anapc7 Hist1h3d Anapc4 Anapc5 Tnrc6a Phc2 Anapc1 Ago4 Phc1 Anapc2 Ago3 Cbx4 Hira Hist1h1c Cbx8 Hist1h2ak Cbx2 Mdm2 Asf1a Hist1h1e Hist1h2ag Bmi1 Hist1h1b Hist1h1a Hist1h2ah Mapkapk5 Sp1 Hist2h3c1 Cdk2 E2f1 Rad50 Ccna1 Rbbp4 Ccna2 Cdk4 Tfdp2 Anapc15 Anapc11 Tfdp1 Anapc10 Fzr1 Ring1 Mapk7 E2f2 E2f3 Cdkn1b Hist3h2ba Fos Tnik Map3k5 Mink1 Erf Map4k4 Txn1 Id1 Eed Cebpb Cbx6 Kdm6b Ubc Igfbp7 Cdkn2a H2afz Ets2 H2afx Ets1 Cdkn2b Mapk3 Mapk1 Trp53 Hist2h2aa1 Hist1h3h Mapk11 Ehmt2 Mapk14 Ehmt1 Mov10 PROTON OLIGOPEPTIDE COTRANSPORTERS%REACTOME%R-HSA-427975.2 Proton oligopeptide cotransporters Slc15a2 Slc15a1 Slc15a4 Slc15a3 MRNA EDITING: C TO U CONVERSION%REACTOME DATABASE ID RELEASE 59%72200 mRNA Editing: C to U Conversion Apobec3 A1cf Apobec2 Apobec1 Apobec4 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES%REACTOME DATABASE ID RELEASE 59%499943 Synthesis and interconversion of nucleotide di- and triphosphates Dtymk Ctps Txn1 Ak6 Guk1 Dctpp1 Ctps2 Ak1 Ak2 Glrx Taf9 Rrm2b Nme1 Nme4 Ak8 Nudt13 Ak7 Ak5 Rrm2 Rrm1 Cmpk1 Txnrd1 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE%REACTOME DATABASE ID RELEASE 59%69052 Switching of origins to a post-replicative state Psmc6 Psmc5 Psmc2 Psmd2 Psmb9 Psmf1 Psmb8 Rb1 Psme4 Mcm6 Cdc6 Cdk2 Mcm3 Mcm2 Mcm5 Mcm4 Psmc1 Ccna1 Psmc4 Psmc3 Ccna2 Psme3 Fzr1 Orc4 Orc5 Mcm8 Mcm7 Cdt1 Orc2 Orc3 Orc6 Orc1 Cdkn1b Cdkn1a Psmd12 Psma7 Psmd11 Psmd14 Psma5 Psmb5 Psmb4 Ubc Psmd13 Psmd10 Psma4 Psmb7 Psma3 Psma6 Psmb6 Psmb2 Psmb3 Psmb1 Psma2 Psma1 Psmd9 Psmd1 Shfm1 Psme2 Psme1 Psmd3 Psmd4 Psmb10 Psmd6 Psmd5 Psmd7 Psmb11 Psmd8 HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME DATABASE ID RELEASE 59%629594 Highly calcium permeable postsynaptic nicotinic acetylcholine receptors Chrna9 Chrnb2 Chrna4 Chrna5 Chrnb4 Chrnb3 Chrna3 Chrna1 Chrna6 Chrna7 Chrna2 MULTIFUNCTIONAL ANION EXCHANGERS%REACTOME DATABASE ID RELEASE 59%427601 Multifunctional anion exchangers Slc26a11 Slc26a1 Slc26a3 Slc26a4 Slc5a12 Slc26a9 Slc26a2 Slc26a7 TP53 REGULATES TRANSCRIPTION OF CELL CYCLE GENES%REACTOME DATABASE ID RELEASE 59%6791312 TP53 Regulates Transcription of Cell Cycle Genes E2f7 Cnot4 Cnot6l Cnot7 Cdc25c Cdkn1a Cnot6 Btg2 Sfn Cnot1 Plk3 Arid3a Cnot3 Pcna Gadd45a Cnot2 Cenpj Cnot8 Rbl2 Rbl1 Ccne1 Plk2 Bax Cdk2 Cdk1 E2f4 Pcbp4 Ccne2 E2f1 Ccna1 Ccna2 Prmt1 Tfdp2 Zfp385a Tnks1bp1 Tfdp1 Trp53 Cnot11 Npm1 Carm1 Aurka Cnot10 Cdkn1b Rqcd1 Ep300 Rgcc PTK6 ACTIVATES STAT3%REACTOME DATABASE ID RELEASE 59%8849474 PTK6 Activates STAT3 Stat3 Socs3 Stap2 Ptk6 VITAMIN D (CALCIFEROL) METABOLISM%REACTOME%R-HSA-196791.2 Vitamin D (calciferol) metabolism Cyp24a1 Lgmn Cyp2r1 Cubn Gc Cyp27b1 Lrp2 SHC1 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 59%180336 SHC1 events in EGFR signaling Akap9 Ppp2r1a Csf2 Jak1 Frs2 Nras Frs3 Rasgrf1 Psmf1 Raf1 Psme4 Il5ra Fgf1 Il17rd Fgf2 Csk Cnksr1 Cnksr2 Erbb2 Fgf9 Ptk2 Fgf7 Psme3 Fgf6 Fgf4 Fgf3 Ppp5c Ranbp9 Ppp2cb Shc1 Lamtor2 Nrg2 Ppp2ca Shc3 Nrg1 Shc2 Psma7 Artn Nrtn Brap Psmb5 Psmb4 Ubc Nrg3 Psmb7 Nrg4 Psmb6 Psmb2 Psmb3 Psmb1 Mapk3 Mapk1 Ksr1 Ptpra Dusp16 Dusp10 Map3k11 Paqr3 Psme2 Psme1 Ncam1 Sos1 Braf Psmb10 Apbb1ip Psmb11 Csf2rb2 Rapgef2 Csf2ra Actn2 Nf1 Pdgfrb Pdgfra Kbtbd7 Il2rg Arrb2 Egfr Arrb1 Ret Vwf Sptan1 Pspn Map2k1 Rbx1 Fgg Map2k2 Cul3 Psmd12 Pdgfb Psmd11 Rasgef1a Psmd14 Rasa3 Rasa4 Psmd13 Psmd10 Il2 Rasa2 Rasa1 Nefl Spred3 Kit Spred2 Grin2a Spred1 Spta1 Il5 Ppp2r1b Sptbn4 Ywhab Kras Gdnf Shfm1 Irs2 Syngap1 Hbegf Irs1 Il3ra Btc Il2ra Il2rb Angpt1 Psmc6 Egf Fgf23 Psmc5 Fgf22 Mark3 Psmc2 Fgf20 Psmd2 Dab2ip Tek Psmb9 Psmb8 Araf Hras Grin1 Ppp2r5e Dlg4 Ppp2r5c Ppp2r5d Ppp2r5a Psmc1 Psmc4 Psmc3 Sptbn2 Itgb3 Sptbn1 Fyn Phb Grin2c Rasgrp4 Rasgrp3 Pebp1 Ppp2r5b Rasgrp1 Tln1 Fga Fgb Grin2d Grin2b Sptb Hgf Gfra2 Gfra3 Gfra4 Ereg Jak2 Pea15a Itga2b Rap1a Jak3 Wdr83 Camk2d Rap1b Camk2a Fgfr4 Camk2b Psma5 Rasal3 Rasal2 Psma4 Psma3 Psma6 Vcl Camk2g Psma2 Psma1 Gfra1 Psmd9 Dusp7 Iqgap1 Fgf16 Dusp6 Dusp9 Fgf15 Dusp8 Klb Fgf18 Psmd1 Met Fn1 Rasal1 Dusp1 Psmd3 Psmd4 Psmd6 Psmd5 Dusp2 Psmd7 Dusp5 Psmd8 Fgf10 Dusp4 TWIK-RELATED ALKALINE PH ACTIVATED K+ CHANNEL (TALK)%REACTOME DATABASE ID RELEASE 59%1299361 TWIK-related alkaline pH activated K+ channel (TALK) Kcnk16 SERINE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 59%977347 Serine biosynthesis Psph Serinc1 Serinc2 Psat1 Phgdh Serinc5 Serinc4 Serinc3 IKBA VARIANT LEADS TO EDA-ID%REACTOME%R-HSA-5603029.1 IkBA variant leads to EDA-ID Nfkbia Nfkb2 Chuk Nfkb1 Ikbkb Ikbkg Rela NEGATIVE REGULATION OF MAPK PATHWAY%REACTOME%R-HSA-5675221.1 Negative regulation of MAPK pathway Ppp2cb Map2k1 Ppp2ca Mark3 Map2k2 Nras Ppp2r1a Araf Raf1 Hras Brap Ppp2r5e Ubc Ppp2r5c Ppp2r5d Ppp2r5a Mapk3 Mapk1 Ksr1 Ppp2r1b Ywhab Dusp16 Dusp7 Dusp10 Dusp6 Dusp9 Kras Dusp8 Paqr3 Pebp1 Ppp2r5b Dusp1 Braf Ppp5c Dusp2 Dusp5 Dusp4 TRAF6 MEDIATED NF-KB ACTIVATION%REACTOME DATABASE ID RELEASE 59%933542 TRAF6 mediated NF-kB activation Rnf135 Chuk App Traf6 Ikbkb Map3k1 Ager Ikbkg Rela Trim25 Mavs Nfkb2 Nfkbia Nfkb1 Ifih1 Nfkbib Saa3 Traf2 Myd88 Ddx58 Dhx9 S100b SEMA3A PAK DEPENDENT AXON REPULSION%REACTOME DATABASE ID RELEASE 59%399954 Sema3A PAK dependent Axon repulsion Fyn Limk1 Nrp1 Rac1 Pak1 Pak3 Pak2 Hsp90aa1 Plxna2 Hsp90ab1 Fes Plxna4 Plxna3 Plxna1 Sema3a SIGNALING BY CYTOSOLIC FGFR1 FUSION MUTANTS%REACTOME%R-HSA-1839117.2 Signaling by cytosolic FGFR1 fusion mutants Bcr Stat1 Myo18a Stat5b Trim24 Stat5a Cux1 Fgfr1op2 Pik3ca Stat3 Gab2 Cpsf6 Zmym2 Pik3r1 Fgfr1op PROSTANOID LIGAND RECEPTORS%REACTOME%R-HSA-391908.1 Prostanoid ligand receptors Ptgdr2 Tbxa2r Ptger3 Ptgir Ptger4 Ptger1 Ptger2 Ptgdr Ptgfr EPH-EPHRIN MEDIATED REPULSION OF CELLS%REACTOME%R-HSA-3928665.2 EPH-ephrin mediated repulsion of cells Adam10 Ap2m1 Efna2 Efna1 Ap2a1 Efna3 Yes1 Lyn Ap2a2 Ephb2 Ap2s1 Aph1b Dnm1 Fyn Efna4 Efnb3 Tiam1 Efnb1 Rac1 Efna5 Psen2 Ncstn Vav2 Epha1 Clta Ap2b1 Mmp2 Mmp9 Epha3 Cltc Epha2 Epha6 Epha7 Epha8 Ephb1 Ephb4 Epha4 Epha5 Ephb6 Vav3 Efnb2 Ephb3 Cltb BLOCH PATHWAY%REACTOME DATABASE ID RELEASE 59%6807047 Bloch pathway Dhcr7 Dhcr24 Ebp Sc5d ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION%REACTOME DATABASE ID RELEASE 59%450302 activated TAK1 mediates p38 MAPK activation Map3k7 Mapkapk2 Irak2 Irak1 Map2k6 Tab1 Tab2 Traf6 Tab3 Ube2v1 Ripk2 Ube2n Map2k3 Ikbkg Mapk11 Mapk14 Mapkapk3 Nod2 Nod1 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING%REACTOME DATABASE ID RELEASE 59%2173788 Downregulation of TGF-beta receptor signaling Ppp1cc Tgfb1 Smurf1 Smad2 Smad7 Stub1 Xpo1 Uchl5 Smad3 Ppp1ca Strap Ppp1r15a Ubc Mtmr4 Nedd4l Ppp1cb Tgfbr1 Pmepa1 Bambi Usp15 Tgfbr2 Smurf2 MAPK1 MAPK3 SIGNALING%REACTOME DATABASE ID RELEASE 59%5684996 MAPK1 MAPK3 signaling Akap9 Ppp2r1a Il6 Csf2 Jak1 Tyk2 Frs2 Nras Frs3 Rasgrf1 Psmf1 Raf1 Psme4 Il5ra Fgf1 Il17rd Fgf2 Cnksr1 Csk Cnksr2 Erbb2 Fgf9 Ptk2 Fgf7 Psme3 Fgf6 Fgf4 Fgf3 Ppp5c Ranbp9 Ppp2cb Shc1 Lamtor2 Nrg2 Ppp2ca Shc3 Nrg1 Shc2 Psma7 Artn Nrtn Brap Psmb5 Psmb4 Ubc Nrg3 Psmb7 Nrg4 Psmb6 Psmb2 Psmb3 Psmb1 Mapk3 Mapk1 Ksr1 Il6ra Ptpra Dusp16 Dusp10 Map3k11 Paqr3 Psme2 Psme1 Ncam1 Sos1 Braf Psmb10 Apbb1ip Psmb11 Csf2rb2 Rapgef2 Csf2ra Actn2 Nf1 Pdgfrb Pdgfra Kbtbd7 Il2rg Arrb2 Egfr Arrb1 Ret Vwf Sptan1 Pspn Map2k1 Rbx1 Fgg Map2k2 Cul3 Psmd12 Pdgfb Psmd11 Rasgef1a Psmd14 Rasa3 Rasa4 Psmd13 Psmd10 Il2 Rasa2 Rasa1 Nefl Spred3 Kit Spred2 Grin2a Spred1 Spta1 Il5 Ppp2r1b Sptbn4 Ywhab Kras Gdnf Shfm1 Irs2 Syngap1 Hbegf Irs1 Il3ra Btc Il2ra Il2rb Angpt1 Ptpn11 Psmc6 Egf Fgf23 Psmc5 Fgf22 Mark3 Psmc2 Fgf20 Psmd2 Dab2ip Tek Psmb9 Psmb8 Araf Hras Grin1 Ppp2r5e Dlg4 Cdk1 Ppp2r5c Ppp2r5d Ppp2r5a Psmc1 Psmc4 Psmc3 Sptbn2 Itgb3 Sptbn1 Fyn Phb Grin2c Rasgrp4 Rasgrp3 Pebp1 Ppp2r5b Rasgrp1 Tln1 Fga Fgb Grin2d Grin2b Sptb Hgf Gfra2 Gfra3 Gfra4 Ereg Jak2 Pea15a Itga2b Rap1a Jak3 Wdr83 Camk2d Rap1b Camk2a Fgfr4 Camk2b Psma5 Rasal3 Rasal2 Psma4 Psma3 Psma6 Vcl Camk2g Psma2 Psma1 Gfra1 Psmd9 Dusp7 Iqgap1 Fgf16 Dusp6 Dusp9 Fgf15 Dusp8 Klb Fgf18 Psmd1 Met Fn1 Rasal1 Dusp1 Psmd3 Psmd4 Psmd6 Psmd5 Dusp2 Psmd7 Dusp5 Psmd8 Fgf10 Dusp4 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA%REACTOME%R-HSA-3134975.2 Regulation of innate immune responses to cytosolic DNA Tmem173 Trim21 Ubc Tbk1 Ddx41 Nlrp4e Dtx4 Trim32 Zbp1 Trim56 Irf3 Trex1 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS%REACTOME DATABASE ID RELEASE 59%1971475 A tetrasaccharide linker sequence is required for GAG synthesis Agrn Bgn Dcn Bcan B3gat3 B3gat2 B3gat1 Cspg4 Cspg5 B4galt7 Ncan Xylt2 Vcan Xylt1 Sdc3 Sdc4 Gpc6 Sdc2 Gpc3 Sdc1 Gpc5 Gpc2 Gpc4 B3galt6 Hspg2 Gpc1 NA+ CL- DEPENDENT NEUROTRANSMITTER TRANSPORTERS%REACTOME%R-HSA-442660.1 Na+ Cl- dependent neurotransmitter transporters Slc6a11 Slc6a9 Slc6a5 Slc6a6 Slc18a1 Slc6a20a Slc6a18 Slc6a19 Slc6a1 Slc6a2 Slc6a13 Slc6a15 Slc6a14 Slc6a12 Slc22a2 Slc18a2 Slc22a1 Slc6a3 Slc6a7 PROGRAMMED CELL DEATH%REACTOME%R-HSA-5357801.1 Programmed Cell Death Casp9 Prkcd Lmnb1 Ywhae Hist1h1d H1f0 Opa1 Oma1 Bid Mapk8 Ppp3r1 Sptan1 Dcc Fas Casp8 Fadd Apc Tradd Fasl Ripk1 Tnfrsf10b Bmx Tnfsf10 Psmd12 Psmd11 Xiap Psmd14 Casp3 Bcap31 Diablo Tjp1 Casp7 Tjp2 Psmd13 Psmd10 Prkcq Arhgap10 Trp73 Dsg1a Traf2 Acin1 Stk26 Nmt1 Stk24 Dsg3 Dsp Dnm1l Dsg2 Ticam2 Ywhab Ripk3 Birc3 Dapk2 Birc2 Bcl2 Fnta Ticam1 Bcl2l1 Bak1 Satb1 Gzmb Pkp1 Unc5b Bmf Tlr4 Tlr3 Ly96 Dapk3 Shfm1 Dapk1 Cd14 Pak2 Appl1 Unc5a Hist1h1c Hist1h1e Hist1h1b Hist1h1a Casp6 Gas2 Vim Gsn Psmc6 Trp53bp2 Psmc5 Psmc2 Psmd2 Ppp1r13b Ywhag Clspn Psmb9 Psmf1 Psmb8 Psme4 Bax Bad Dynll2 E2f1 Psmc1 Psmc4 Ptk2 Psmc3 Psme3 Tfdp2 Tfdp1 Trp63 Dynll1 Dbnl Apaf1 Rock1 Ppp3cc Cdh1 Ywhaz Ywhah Sfn Akt2 Akt3 Psma7 Add1 Psma5 Psmb5 Psmb4 Ubc Psma4 Psma3 Psmb7 Psma6 Psmb6 Psmb2 Psmb3 Psma2 Psmb1 Psma1 Akt1 Psmd9 Plec Trp53 Kpnb1 Mlkl Psmd1 Psme2 Hmgb2 Dffb Psme1 Bcl2l11 Dffa Kpna1 Psmd3 Psmd4 Psmb10 Psmd6 Psmd5 Psmd7 Psmb11 Psmd8 Maged1 GAMMA-CARBOXYLATION, TRANSPORT, AND AMINO-TERMINAL CLEAVAGE OF PROTEINS%REACTOME%R-HSA-159854.3 Gamma-carboxylation, transport, and amino-terminal cleavage of proteins Furin Proz F10 Pros1 Gas6 F9 F2 F7 Ggcx Proc TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES%REACTOME%R-HSA-425393.2 Transport of inorganic cations anions and amino acids oligopeptides Slc26a11 Slc1a3 Slc1a2 Slc12a4 Slc1a7 Slc1a6 Slc38a2 Slc12a5 Slc1a1 Slc12a1 Slc32a1 Slc12a2 Slc12a3 Slc12a6 Slc12a7 Slc43a1 Slc25a22 Slc3a1 Slc43a2 Slc25a26 Slc4a1 Slc17a5 Slc25a18 Slc6a12 Ctns Slc5a8 Slc1a5 Slc1a4 Slc3a2 Slc6a6 Slc6a20a Slc6a18 Slc6a19 Slc7a5 Slc6a15 Slc6a14 Slc36a1 Slc36a2 Slc25a10 Slc38a1 Slc34a1 Slc34a3 Slc20a1 Slc20a2 Slc34a2 Slc8b1 Slc38a5 Slc38a4 Slc38a3 Slc7a6 Slc7a1 Slc7a3 Slc7a9 Slc7a8 Slc7a7 Slc26a1 Slc4a7 Slc4a9 Slc4a8 Slc26a2 Slc4a3 Slc7a10 Slc4a4 Slc4a2 Slc4a5 Slc7a11 Slc8a2 Slc8a1 Slc24a4 Slc24a3 Slc24a2 Slc24a1 Slc8a3 Slc15a3 Slc4a10 Slc5a12 Slc9a1 Slc9a6 Ahcyl2 Slc17a1 Slc9a5 Slc5a5 Slc9a4 Slc9a3 Slc9a2 Slc15a2 Slc9a9 Slc15a1 Slc9a8 Slc9a7 Slc24a5 Slc17a6 Slc17a8 Slc15a4 Slc26a3 Slc26a4 Sri Slc26a9 Slc26a7 DOWNREGULATION OF ERBB2 SIGNALING%REACTOME%R-HSA-8863795.2 Downregulation of ERBB2 signaling Erbb2ip Egf Ptpn18 Ptpn12 Nrg2 Ereg Nrg1 Akt2 Akt3 Stub1 Cdc37 Matk Hsp90aa1 Cul5 Rnf41 Usp8 Ubc Egfr Nrg3 Nrg4 Hbegf Erbb2 Btc Akt1 CARNITINE SYNTHESIS%REACTOME DATABASE ID RELEASE 59%71262 Carnitine synthesis Tmlhe Bbox1 Shmt1 Aldh9a1 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY%REACTOME%R-HSA-383280.1 Nuclear Receptor transcription pathway Esr2 Rara Rarb Esr1 Med1 Nr1d1 Nr2c1 Ppara Pgr Nr2c2 Ar Pparg Nr1d2 Nrbp1 Nr1h2 Rxrg Nr2c2ap Rarg Rorc Hnf4a Hnf4g Rorb Esrrb Rora Thrb Esrra Rxrb Nr2f1 Esrrg Rxra Nr2f6 Nr4a2 Thra Vdr Nr5a1 Nr4a1 Nr2e1 Ppard Nr0b2 PI3K AKT SIGNALING%REACTOME DATABASE ID RELEASE 59%1257604 PI3K AKT Signaling Casp9 Tsc2 Pdgfrb Pdgfra Ppp2r1a Mlst8 Vav1 Egfr Gab1 Mtor Phlpp1 Phlpp2 Ins2 Cd86 Cdkn1a Pdgfb Cd80 Kit Ppp2r1b Ago2 Ago1 Tnrc6c Insr Gsk3a Gsk3b Tnrc6b Tnrc6a Ago4 Ago3 Trat1 Irs2 Mdm2 Lck Pten Hbegf Irs1 Btc Ptpn11 Trib3 Egf Fgf23 Fgf22 Fgf20 Frs2 Ppp2r5e Mapkap1 Fgf1 Bad Ppp2r5c Fgf2 Rps6kb2 Ppp2r5d Ppp2r5a Erbb2 Fgf9 Pik3cb Fgf7 Foxo3 Pik3cd Fgf6 Foxo1 Fgf4 Fgf3 Fyn Creb1 Ppp2r5b Ier3 Pik3ca Cdkn1b Nr4a1 Prr5 Hgf Ppp2cb Pip5k1a Chuk Ereg Nrg2 Ppp2ca Nrg1 Akt2 Akt3 Fgfr4 Nrg3 Nrg4 Akt1s1 Mapk3 Pip5k1b Akt1 Mapk1 Cd19 Pip5k1c Fgf16 Pip4k2b Pip4k2a Fgf15 Trp53 Pip4k2c Klb Fgf18 Pik3ap1 Them4 Met Rictor Pdpk1 Pik3r3 Pik3r1 Fgf10 Pik3r2 Mov10 COPI-DEPENDENT GOLGI-TO-ER RETROGRADE TRAFFIC%REACTOME%R-HSA-6811434.1 COPI-dependent Golgi-to-ER retrograde traffic Zw10 Arfgap3 Arfgap1 Arfgap2 Kif12 Copb2 Kif15 Kif19a Kif6 Copb1 Kif1c Kif21a Copz1 Kif21b Kif1b Kif1a Copz2 Copg1 Arf1 Kdelr1 Arf3 Kif11 Arf4 Rab1 Klc3 Copa Klc2 Klc4 Tmed3 Racgap1 Cope Arcn1 Sec22b Cenpe Kif2c Stx18 Kif2b Kif18a Kif3c Nsf Kif3b Kif3a Kif2a Tmed9 Kif18b Gbf1 Napb Napg Kifc5b Klc1 Kifc2 Napa Kif16b Kif26a Kif5a Kif5b Kif26b Kif13b Rab1b Kif20b Surf4 Kif4 Arf5 Kif20a Kdelr2 Kdelr3 Kifap3 Rint1 Bnip1 Kif22 Kif27 Kif23 Use1 Kif9 PEPTIDE HORMONE BIOSYNTHESIS%REACTOME%R-HSA-209952.1 Peptide hormone biosynthesis Lhb Inhbc Inhbe Pomc Fshb Inha Inhba Pcsk1 Inhbb Tshb Cga TELOMERE MAINTENANCE%REACTOME%R-HSA-157579.1 Telomere Maintenance Dkc1 Nhp2 Pcna Rfc5 Rfc3 Rfc2 Rfc4 H2afj Rfc1 H2afb2 Pole Dna2 Pold1 Pold2 Pold3 Pold4 Prim1 Pole2 Rpa2 Rpa1 Hist3h2ba Hist2h2be Rpa3 Pola1 Pola2 Hist2h2ac Lig1 Fen1 Pole4 Prim2 Pole3 Hist1h2bg Tinf2 Pot1a Hist1h2bh Wrap53 Tert Terf1 Terf2 Hist1h2bp Acd Hist1h2bm Ruvbl2 Ruvbl1 Hist1h2bj Hist1h2bb H2afz Terf2ip H2afx Hist2h2aa1 Hist1h3h Hist1h2ak Hist1h2ag Hist1h2ah GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY%REACTOME%R-HSA-399721.1 Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity Akap5 Grip1 Cacng8 Gria2 Grip2 Cacng4 Prkcg Cacng3 Dlg1 Cacng2 Myo6 Nsf Tspan7 Camk2d Pick1 Gria3 Camk2a Gria4 Prkcb Ap2a1 Camk2b Prkca Dlg4 Camk2g Mdm2 Gria1 NCAM SIGNALING FOR NEURITE OUT-GROWTH%REACTOME DATABASE ID RELEASE 59%375165 NCAM signaling for neurite out-growth Agrn Akap9 Ppp2r1a Csf2 Jak1 Cntn2 Rps6ka5 Frs2 Nras Frs3 Rasgrf1 Psmf1 Raf1 Psme4 Il5ra Fgf1 Il17rd Fgf2 Cnksr1 Csk Cnksr2 Erbb2 Fgf9 Ptk2 Fgf7 Psme3 Fgf6 Fgf4 Fgf3 Ppp5c Ranbp9 Ppp2cb Shc1 Lamtor2 Nrg2 Ppp2ca Shc3 Nrg1 Shc2 Psma7 Artn Nrtn Brap Psmb5 Psmb4 Ubc Nrg3 Psmb7 Cacna1s Nrg4 Psmb6 Psmb2 Psmb3 Psmb1 Mapk3 Mapk1 Ksr1 Ptpra Dusp16 Dusp10 Map3k11 Cacnb2 Paqr3 Cacnb3 Cacna1c Cacna1d Psme2 Psme1 Ncam1 Sos1 Braf Psmb10 Apbb1ip Col6a1 Col6a2 Col6a3 Cacnb4 Col6a6 Cacnb1 Psmb11 Csf2rb2 Rapgef2 Csf2ra Actn2 Nf1 Pdgfrb Pdgfra Kbtbd7 Il2rg Arrb2 Egfr Arrb1 Ret Vwf Sptan1 Pspn Col4a5 Map2k1 Rbx1 Fgg Map2k2 Cul3 Psmd12 Pdgfb Psmd11 St8sia2 Col9a1 Rasgef1a Col9a2 Col9a3 Psmd14 Rasa3 Rasa4 Psmd13 Psmd10 Il2 Rasa2 Rasa1 Nefl Spred3 Kit Ncan Spred2 Grin2a Spred1 Spta1 Il5 Sptbn4 Ppp2r1b Ywhab Kras Gdnf Shfm1 Irs2 Syngap1 Hbegf Irs1 Il3ra Btc Il2ra Il2rb Angpt1 Psmc6 Egf Fgf23 Psmc5 Fgf22 Mark3 Psmc2 Fgf20 Psmd2 Dab2ip Tek Psmb9 Psmb8 Araf Hras Grin1 Ppp2r5e Dlg4 Ppp2r5c Ppp2r5d Ppp2r5a Psmc1 Psmc4 Psmc3 Sptbn2 Sptbn1 Itgb3 Fyn Cacna1i Creb1 Cacna1h Phb Grin2c Rasgrp4 Cacna1g Rasgrp3 Prnp Pebp1 Ppp2r5b Rasgrp1 Tln1 Col4a3 Col4a2 Col4a4 Col4a1 Fga Fgb Grin2d Grin2b Sptb Hgf Gfra2 Gfra3 Gfra4 Ereg Jak2 Pea15a Itga2b Rap1a Jak3 Wdr83 Camk2d Rap1b Camk2a Fgfr4 Camk2b Psma5 Rasal3 Rasal2 Psma4 Psma3 Psma6 Vcl Camk2g Psma2 Psma1 Gfra1 Psmd9 Dusp7 Iqgap1 Fgf16 Dusp6 Dusp9 Fgf15 Dusp8 Klb Fgf18 Psmd1 Met Fn1 Rasal1 Dusp1 Psmd3 Psmd4 Psmd6 Psmd5 St8sia4 Dusp2 Psmd7 Dusp5 Psmd8 Fgf10 Dusp4 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE%REACTOME DATABASE ID RELEASE 59%174414 Processive synthesis on the C-strand of the telomere Rpa2 Rpa1 Dna2 Rpa3 Pold1 Pold2 Pcna Pold3 Pold4 Lig1 Fen1 FCGR ACTIVATION%REACTOME%R-HSA-2029481.1 FCGR activation Hck Fyn Yes1 Lyn Fcgr4 Fgr Fcgr3 Syk Fcgr1 Cd3g SIGNALING BY ROBO RECEPTOR%REACTOME%R-HSA-376176.1 Signaling by Robo receptor Srgap2 Arhgap39 Cap1 Slit2 Clasp2 Srgap3 Abl2 Srgap1 Cap2 Nck2 Pfn2 Pfn1 Nck1 Evl Clasp1 Rac1 Pak1 Pak3 Pak2 Vasp Sos1 Sos2 Pak7 Robo2 Pak4 Robo1 Pak6 Abl1 Gpc1 FGFR2C LIGAND BINDING AND ACTIVATION%REACTOME%R-HSA-190375.3 FGFR2c ligand binding and activation Fgf1 Fgf23 Fgf16 Fgf2 Fgf20 Fgf18 Fgf9 Fgf6 Fgf4 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%R-HSA-1445148.1 Translocation of GLUT4 to the plasma membrane Prkag2 Prkag1 Prkag3 Prkaa2 Ywhag Ywhae Stxbp3 Rab8a Slc2a4 Rala Rab14 Myh4 Myo1c Myh7 Myh6 Rab11a Myh2 Myh8 Aspscr1 Rac1 C2cd5 Myh1 Myh3 Myo5a Rab13 Rab10 Ywhaz Exoc3 Exoc4 Ywhah Sfn Stx4a Akt2 Myh15 Exoc1 Exoc5 Exoc6 Kif3b Myh13 Exoc8 Exoc7 Kif3a Exoc2 Ralgapb Prkab1 Tbc1d1 Lnpep Akt1 Tbc1d4 Ywhab Rab4a Prkab2 Snap23 Kifap3 Vamp2 Rhoq SIGNALING BY HIPPO%REACTOME DATABASE ID RELEASE 59%2028269 Signaling by Hippo Sav1 Amotl2 Ywhab Amotl1 Nphp4 Yap1 Ywhae Dvl2 Casp3 Tjp1 Tjp2 Lats2 Wwtr1 Lats1 Stk3 Mob1a Stk4 Wwc1 Mob1b SIGNALING BY FGFR3%REACTOME DATABASE ID RELEASE 59%5654741 Signaling by FGFR3 Ppp2cb Spry2 Fgf23 Ppp2ca Fgf20 Frs2 Nras Ppp2r1a Frs3 Mknk1 Plcg1 Hras Fgf1 Ubc Cbl Gab1 Fgf2 Fgf9 Mapk3 Fgf4 Mapk1 Fgf16 Kras Fgf18 Pik3ca Sos1 Braf Galnt3 Pik3r1 Ptpn11 SODIUM CALCIUM EXCHANGERS%REACTOME DATABASE ID RELEASE 59%425561 Sodium Calcium exchangers Slc24a4 Slc24a3 Slc24a2 Slc24a1 Slc8a3 Slc8b1 Sri Slc24a5 Slc8a2 Slc8a1 PLCG1 EVENTS IN ERBB2 SIGNALING%REACTOME DATABASE ID RELEASE 59%1251932 PLCG1 events in ERBB2 signaling Egf Egfr Erbb2 Plcg1 ORGANIC ANION TRANSPORT%REACTOME%R-HSA-561048.1 Organic anion transport Slc22a12 Slc22a6 Slc22a8 Slc22a7 METHYLATION OF MESEH FOR EXCRETION%REACTOME DATABASE ID RELEASE 59%2408552 Methylation of MeSeH for excretion Inmt SIGNALING BY SCF-KIT%REACTOME%R-HSA-1433557.1 Signaling by SCF-KIT Akap9 Ppp2r1a Rac1 Csf2 Cd86 Jak1 Cd80 Stat3 Cma1 Frs2 Nras Frs3 Rasgrf1 Psmf1 Raf1 Psme4 Il5ra Fgf1 Bad Il17rd Fgf2 Cnksr1 Csk Cnksr2 Erbb2 Fgf9 Ptk2 Fgf7 Psme3 Fgf6 Fgf4 Fgf3 Ppp5c Ranbp9 Ppp2cb Shc1 Lamtor2 Chuk Nrg2 Ppp2ca Shc3 Nrg1 Akt2 Akt3 Shc2 Psma7 Artn Nrtn Brap Psmb5 Gab2 Psmb4 Ubc Nrg3 Psmb7 Nrg4 Psmb6 Psmb2 Psmb3 Psmb1 Mapk3 Akt1 Mapk1 Ksr1 Ptpra Dusp16 Dusp10 Map3k11 Pip4k2b Pip4k2a Trp53 Pip4k2c Paqr3 Pik3ap1 Psme2 Psme1 Ncam1 Sos1 Rictor Braf Psmb10 Apbb1ip Psmb11 Csf2rb2 Tec Rapgef2 Grap2 Csf2ra Mov10 Grb7 Casp9 Actn2 Nf1 Tsc2 Pdgfrb Stat5b Pdgfra Stat5a Mlst8 Kbtbd7 Prkca Vav1 Il2rg Arrb2 Egfr Gab1 Arrb1 Mtor Ret Phlpp1 Vwf Phlpp2 Ins2 Sptan1 Mmp9 Pspn Map2k1 Rbx1 Fgg Cdkn1a Map2k2 Cul3 Psmd12 Pdgfb Psmd11 Rasgef1a Psmd14 Yes1 Rasa3 Lyn Sh2b3 Rasa4 Sh2b2 Psmd13 Cbl Psmd10 Socs6 Il2 Socs1 Rasa2 Rasa1 Nefl Spred3 Kit Spred2 Grin2a Spta1 Spred1 Il5 Sptbn4 Ppp2r1b Ywhab Ago2 Ago1 Tnrc6c Kras Insr Gsk3a Gsk3b Tnrc6b Gdnf Shfm1 Tnrc6a Ago4 Ago3 Trat1 Irs2 Mdm2 Lck Syngap1 Pten Hbegf Irs1 Ptpn6 Il3ra Fes Btc Il2ra Il2rb Ptpn11 Angpt1 Trib3 Psmc6 Egf Fgf23 Psmc5 Fgf22 Mark3 Psmc2 Fgf20 Psmd2 Dab2ip Tek Psmb9 Psmb8 Araf Hras Grb10 Grin1 Ppp2r5e Fer Mapkap1 Ptpru Dlg4 Ppp2r5c Grap Rps6kb2 Ppp2r5d Ppp2r5a Psmc1 Psmc4 Psmc3 Pik3cb Foxo3 Sptbn2 Pik3cd Foxo1 Sptbn1 Itgb3 Fyn Creb1 Phb Grin2c Stat1 Rasgrp4 Rasgrp3 Pebp1 Ppp2r5b Rasgrp1 Ier3 Tln1 Pik3ca Cdkn1b Fga Fgb Grin2d Grin2b Nr4a1 Sptb Prr5 Hgf Gfra2 Gfra3 Pip5k1a Chek1 Gfra4 Ereg Jak2 Pea15a Itga2b Rap1a Jak3 Wdr83 Camk2d Rap1b Camk2a Fgfr4 Camk2b Psma5 Rasal3 Rasal2 Psma4 Psma3 Psma6 Akt1s1 Vcl Camk2g Psma2 Psma1 Gfra1 Pip5k1b Cd19 Pip5k1c Psmd9 Dusp7 Iqgap1 Fgf16 Dusp6 Dusp9 Fgf15 Dusp8 Klb Fgf18 Them4 Psmd1 Met Fn1 Rasal1 Dusp1 Psmd3 Psmd4 Pdpk1 Psmd6 Psmd5 Dusp2 Pik3r3 Psmd7 Pik3r1 Dusp5 Psmd8 Fgf10 Pik3r2 Dusp4 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION%REACTOME DATABASE ID RELEASE 59%983168 Antigen processing: Ubiquitination & Proteasome degradation Ube2b Ube2r2 Ube2q2 Ube2a Lmo7 Lrrc41 Rchy1 Rlim Hace1 Ube2l6 Btrc Fbxo4 Fbxw11 Fbxo6 Arih2 Rnf34 Znrf1 Dtx3l Cdc34 Arel1 Rnf217 Uba7 Mib2 Rnf213 Nedd4l Rnf220 Lonrf1 Cul7 Uba3 Rnf144b Atg7 Trim41 Ube2e3 Hectd3 Cul2 Hectd1 Hectd2 Rnf123 Ube2o Ube2f Npepps Ube3a Ube2m Ube3c Ube3b Ube2z Ube2w Ube2k Ube2h Lrr1 Ubox5 Vhl Fbxl5 Fbxl3 Vprbp Gan Hecw2 Psmf1 Traf7 Psme4 Ube2v2 Skp1a Kctd7 Kctd6 Traip Skp2 Cul1 Psme3 Rnf4 Tpp2 Blmh Huwe1 Ccnf Kbtbd13 Trim69 Sh3rf1 Det1 Trim71 Ltn1 Asb18 Asb11 Trim63 Asb16 Asb17 Asb14 Asb12 Asb13 Trim39 Trim50 Trim36 Fbxl7 Asb15 Fbxl18 Trim37 Fbxw8 Fbxl16 Fbxl19 Fbxl14 Fbxl13 Fbxl15 Fbxl12 Mex3c Fbxl8 Psma7 Fbxl4 Cul5 Rnf41 Psmb5 Fbxo7 Psmb4 Fbxo9 Zbtb16 Ubc Itch Psmb7 Klhl2 Wwp1 Nedd4 Psmb6 Klhl9 Psmb2 Psmb3 Klhl20 Psmb1 Klhl22 Klhl21 Fbxo2 Lnpep Trim11 Klhl25 Trim9 Klhl13 Herc2 Klhl11 Pja2 Lrsam1 Pja1 Rbck1 Tceb1 Spsb1 Psme2 Ubr2 Ubr1 Psme1 Trip12 Spsb4 Ubr4 Mkrn1 Herc1 Ubac1 Herc3 Psmb10 Herc4 Spsb2 Anapc13 Fbxl21 Smurf2 Fbxl20 Psmb11 Herc6 Klhl41 Klhl42 Siah1a Kbtbd7 Fbxw10 Trim21 Siah2 Trim32 Rbx1 Cul3 Psmd12 Psmd11 Keap1 Psmd14 Psmd13 Psmd10 Ufl1 Socs1 Ube4a Rnf126 Rnf115 Cdc23 Ube2d1 Cdc27 Cdc16 Cdc20 Ube2v1 Ube2c Ube2e1 Ube2n Anapc7 Shfm1 Anapc4 Anapc5 Anapc1 Anapc2 Park2 Psmc6 Psmc5 Kbtbd8 Psmc2 Psmd2 Rnf7 Uba6 Psmb9 Rnf6 Psmb8 Fbxw2 Dzip3 Psmc1 Psmc4 Fbxw5 Ube2q1 Psmc3 Fbxw4 Mgrn1 Fbxw9 Rnf111 Fbxw7 Anapc11 Anapc10 Fzr1 Rnf130 Rnf138 Ube2e2 Cblb Rnf114 Mylip Lnx1 Rnf19a Rnf19b Rnf182 Fbxo30 Fbxo32 Fbxo31 Btbd6 Btbd1 Fbxo27 Fbxo22 Fbxo21 Psma5 Uba5 Ube2d3 Socs3 Psma4 Psma3 Psma6 Fbxo10 Ube2cbp Psma2 Psma1 Fbxo17 Asb5 Psmd9 Asb4 Rnf14 Asb3 Asb2 Asb1 Asb9 Smurf1 Ube2g2 Ube2g1 Psmd1 Stub1 Asb7 Asb6 Fbxo40 Psmd3 Wsb1 Psmd4 Psmd6 Rnf25 Psmd5 Ube2l3 Ube2j1 Psmd7 Uba1 Asb8 Ube2j2 Psmd8 Fbxo44 Fbxo41 NUCLEAR SIGNALING BY ERBB4%REACTOME DATABASE ID RELEASE 59%1251985 Nuclear signaling by ERBB4 Esr1 Nrg2 Ereg Pgr Ncor1 Tab2 Nrg1 Psen2 Wwox Ncstn Yap1 Stat5a Csn2 Nrg3 Nrg4 Hbegf Gfap Btc Adam17 S100b Aph1b Cxcl12 GPVI-MEDIATED ACTIVATION CASCADE%REACTOME%R-HSA-114604.4 GPVI-mediated activation cascade G6b Pdpn Clec1b Gp6 Vav1 Il2rg Il5ra Pik3r6 Pik3r5 Rhoa Lat Pik3cb Pik3cd Fyn Rac1 Plcg2 Syk Pik3ca Csf2 Rhog Vav3 Rhob Shc1 Jak1 Fcer1g Jak2 Akt2 Jak3 Akt3 Gab2 Lyn Il2 Akt1 Il5 Vav2 Prkcz Pdpk1 Lck Rac2 Pik3cg Ptpn6 Pik3r3 Il3ra Pik3r1 Il2ra Il2rb Csf2rb2 Ptpn11 Pik3r2 Csf2ra Lcp2 INTEGRIN ALPHAIIB BETA3 SIGNALING%REACTOME%R-HSA-354192.1 Integrin alphaIIb beta3 signaling Ptpn1 Shc1 Fgg Itga2b Rap1a Rap1b Rapgef4 Rapgef3 Csk Ptk2 Vwf Akt1 Itgb3 Syk Rasgrp1 Fn1 Tln1 Bcar1 Sos1 Rasgrp2 Pdpk1 Apbb1ip Fga Fgb Crk SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 59%2894858 Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Hdac4 Hdac5 Ccnc Cdk8 Notch1 Skp1a Hdac1 Cul1 Maml2 Aph1b Maml1 Hdac2 Ncor1 Ncor2 Mib2 Crebbp Hdac10 Neurl1a Neurl1b Hey1 Hdac11 Ep300 Hey2 Hdac7 Hdac6 Hdac9 Hdac8 Hes5 Rbpj Kat2b Mib1 Kat2a Heyl Hes1 Adam10 Rbx1 Tbl1x Maml3 Ubc Myc Psen2 Ncstn Mamld1 Adam17 Jag2 Dll1 Tbl1xr1 Dll4 Jag1 Hdac3 SIGNALING BY ACTIVIN%REACTOME%R-HSA-1502540.2 Signaling by Activin Smad4 Smad2 Fstl3 Fst Smad3 Acvr1b Drap1 Foxh1 Acvr2b Acvr2a Inhba Inhbb Acvr1c INTERFERON GAMMA SIGNALING%REACTOME DATABASE ID RELEASE 59%877300 Interferon gamma signaling Irf8 Irf7 Irf6 Irf1 Mid1 Prkcd Irf4 Gbp2 Gbp3 Gbp9 Gbp5 Irf2 Gbp7 Trim25 Irf3 Trim12c Trim21 Oasl1 Ifi30 Irf9 Irf5 Ciita Trim68 Fcgr1 Pias1 Trim62 Trim46 Trim45 Trim35 Trim38 H2-M3 Ptpn1 H2-M5 Jak1 Jak2 H2-Q1 Pml Trim26 Ifngr2 Ifng Camk2d Camk2a Ptafr Trim31 Camk2b Trim14 Icam1 Socs3 Ifngr1 Socs1 Mt2 Trim17 Camk2g Oas1g Trim6 Trim10 Trim8 Trim3 Trim2 Vcam1 Oas2 Oas3 Ncam1 H2-Aa H2-Eb1 H2-Q10 Ptpn6 Cd44 B2m Ptpn11 AUTOINTEGRATION RESULTS IN VIRAL DNA CIRCLES%REACTOME DATABASE ID RELEASE 59%177539 Autointegration results in viral DNA circles Psip1 Banf1 Hmga1 SIGNALING BY MST1%REACTOME DATABASE ID RELEASE 59%8852405 Signaling by MST1 Mst1 Spint1 Hpn Mst1r Spint2 PROCESSING OF DNA DOUBLE-STRAND BREAK ENDS%REACTOME%R-HSA-5693607.1 Processing of DNA double-strand break ends Ppp4c Fam175a Pias4 Clspn Rnf168 Trex1 Rfc5 Ube2v2 Rfc3 Cdk2 Brcc3 Trp53bp1 Rfc2 Ccna1 Rad50 Uimc1 Ccna2 Rfc4 Tipin Babam1 Ppp4r2 Rnf4 Nbn Atrip Dna2 Bard1 Rpa2 Rpa1 Mre11a Atm Hist2h2be Hist3h2ba Rpa3 Top3a Ube2i Rad17 Hist1h2bg Hist1h2bh Chek1 Hist1h2bp Rbbp8 Hist1h2bm Topbp1 Hist1h2bj Hist1h2bb Rad9a Blm Rad1 Ubc Rad9b Hus1 Mdc1 H2afx Exo1 Brip1 Herc2 Timeless Bre Sirt6 Kat5 Wrn Ube2n Whsc1 Hist1h3h Brca1 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL%REACTOME DATABASE ID RELEASE 59%198323 AKT phosphorylates targets in the cytosol Casp9 Chuk Cdkn1a Tsc2 Gsk3a Akt2 Gsk3b Akt3 Mdm2 Bad Cdkn1b Akt1s1 Akt1 MISMATCH REPAIR (MMR) DIRECTED BY MSH2:MSH3 (MUTSBETA)%REACTOME DATABASE ID RELEASE 59%5358606 Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Msh3 Pold1 Pold2 Pold3 Pcna Pold4 Rsph10b Msh2 Rpa2 Rpa1 Rpa3 Mlh1 Lig1 Exo1 Pms2 SIGNALING BY NOTCH1%REACTOME%R-HSA-1980143.2 Signaling by NOTCH1 Hdac4 Hdac5 Dner Dlk1 Dtx2 Cdk8 Dtx1 Dtx4 Ccnc Arrb2 Notch1 Skp1a Arrb1 Hdac1 Cul1 Maml2 Hif1a Aph1b Maml1 Hdac2 Ncor1 Ncor2 Mib2 Hdac10 Crebbp Neurl1a Neurl1b Hey1 Hdac11 Hey2 Ep300 Hdac7 Hdac6 Hdac9 Hdac8 Hes5 Rbpj Kat2b Mib1 Kat2a Heyl Hes1 Adam10 Rbx1 Tbl1x Maml3 Ubc Itch Cntn1 Myc Psen2 Ncstn Tle1 Tle4 Tle2 Numb Mamld1 Adam17 Jag2 Dll1 Dll4 Tbl1xr1 Hdac3 Jag1 SYNTHESIS OF PG%REACTOME DATABASE ID RELEASE 59%1483148 Synthesis of PG Cds2 Pld3 Pld2 Pgs1 Pld1 Pld4 FCERI MEDIATED NF-KB ACTIVATION%REACTOME DATABASE ID RELEASE 59%2871837 FCERI mediated NF-kB activation Psmc6 Psmc5 Psmc2 Psmd2 Psmb9 Psmf1 Psmb8 Btrc Psme4 Malt1 Card11 Nfkb1 Fbxw11 Skp1a Psmc1 Psmc4 Psmc3 Cul1 Psme3 Map3k7 Cdc34 Tab1 Rasgrp4 Tab2 Tab3 Bcl10 Rasgrp1 Rela Nfkbia Rasgrp2 Chuk Psmd12 Psma7 Psmd11 Psmd14 Psma5 Lyn Psmb5 Psmb4 Ubc Psmd13 Psmd10 Prkcq Psma4 Psmb7 Psma3 Psma6 Psmb6 Psmb2 Psmb3 Psmb1 Psma2 Psma1 Psmd9 Ube2d1 Traf6 Ikbkb Ube2v1 Ube2n Psmd1 Shfm1 Psme2 Psme1 Ikbkg Psmd3 Psmd4 Pdpk1 Psmb10 Psmd6 Psmd5 Psmd7 Psmb11 Psmd8 ERYTHROCYTES TAKE UP OXYGEN AND RELEASE CARBON DIOXIDE%REACTOME%R-HSA-1247673.1 Erythrocytes take up oxygen and release carbon dioxide Aqp1 Hba-a1 Slc4a1 Car4 Car2 Hbb-bt Hbb-bs Rhag Car1 TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS%REACTOME DATABASE ID RELEASE 59%168271 Transport of Ribonucleoproteins into the Host Nucleus Nup85 Nup160 Nup37 Nup50 Tpr Nup43 Nup133 Ndc1 Nup214 Aaas Nup210 Nup188 Nup54 Nup35 Nupl2 Nup62 Nup205 Nup155 Nup88 Pom121 Rae1 Nup93 Nup153 Kpnb1 Kpna1 Ranbp2 Nup107 SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN%REACTOME%R-HSA-422085.1 Synthesis, secretion, and deacylation of Ghrelin Klf4 Ins2 Pla2g7 Crhr2 Gcg Bche Ucn Igf1 Sec11c Sec11a Ache Lep Pcsk1 Mboat4 Spcs1 Spcs2 Spcs3 CD209 (DC-SIGN) SIGNALING%REACTOME%R-HSA-5621575.1 CD209 (DC-SIGN) signaling Fyn Icam2 Kras Pak1 Nras Prkacb Pak3 Pak2 Raf1 Hras Rela Relb Lyn Crebbp Nfkb1 Ep300 Prkaca Rps6ka5 Cd209a RESOLUTION OF D-LOOP STRUCTURES%REACTOME DATABASE ID RELEASE 59%5693537 Resolution of D-Loop Structures Rbbp8 Blm Eme1 Rad50 Rad51b Rad51c Gen1 Exo1 Brip1 Rad51 Spidr Nbn Rad51ap1 Dna2 Kat5 Wrn Slx4 Bard1 Mus81 Brca1 Palb2 Mre11a Xrcc3 Rad51d Atm Xrcc2 Top3a Rtel1 Brca2 STEROLS ARE 12-HYDROXYLATED BY CYP8B1%REACTOME%R-HSA-211994.1 Sterols are 12-hydroxylated by CYP8B1 Cyp8b1 Ptgis BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME DATABASE ID RELEASE 59%1368108 BMAL1:CLOCK,NPAS2 activates circadian gene expression Med1 Nr1d1 Serpine1 Ppara Tbl1x Helz2 Chd9 Clock Arntl Ppargc1a Nr3c1 Hif1a Creb1 Rora Ncor1 Nampt Rxra Ccrn4l Crtc1 Carm1 Cry1 Bhlhe41 Dbp Cry2 Nrip1 Crebbp Arntl2 Sik1 Bhlhe40 Rbm4 Avp Per2 Per1 Nfil3 Ep300 Smarcd3 Ncoa1 Npas2 Klf15 Ncoa6 F7 Tbl1xr1 Ncoa2 Hdac3 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE%REACTOME%R-HSA-606279.1 Deposition of new CENPA-containing nucleosomes at the centromere Hist1h2bg Hist1h2bh Smarca5 Mis18bp1 Cenpw Hist1h2bp Hist1h2bm Ruvbl1 Hist1h2bj Stra13 Mis18a Itgb3bp Rbbp7 Hist1h2bb Oip5 Rsf1 Cenpu H2afz Casc5 Rbbp4 H2afx Cenpa H2afj Cenpc1 H2afb2 Cenpq Cenpp Hist2h2aa1 Cenpm Cenpl Cenpo Npm1 Cenpn Cenpt Apitd1 Hist1h2ak Hist2h2be Hist3h2ba Hist1h2ag Hist2h2ac Cenph Cenpi Hist1h2ah Cenpk FRS-MEDIATED FGFR1 SIGNALING%REACTOME DATABASE ID RELEASE 59%5654693 FRS-mediated FGFR1 signaling Fgf23 Fgf22 Kras Fgf20 Frs2 Nras Frs3 Hras Sos1 Fgf1 Fgf2 Fgf9 Ptpn11 Fgf6 Fgf10 Fgf4 Fgf3 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP)%REACTOME DATABASE ID RELEASE 59%2426168 Activation of gene expression by SREBF (SREBP) Nfyb Lss Nfyc Med1 Mvk Ppara Tbl1x Helz2 Mtf1 Srebf2 Pmvk Nfya Sp1 Acacb Fdps Sqle Chd9 Acaca Ggps1 Sc5d Fasn Elovl6 Cyp51 Gpam Tm7sf2 Fdft1 Rxra Carm1 Scd1 Crebbp Dhcr7 Smarcd3 Ncoa1 Mvd Idi1 Ncoa6 Tbl1xr1 Ncoa2 TP53 REGULATES TRANSCRIPTION OF CELL DEATH GENES%REACTOME%R-HSA-5633008.2 TP53 Regulates Transcription of Cell Death Genes Fas Prelid1 Perp Trp53bp2 Birc5 Pidd1 Tmem219 Tnfrsf10b Trp53inp1 Ppp1r13b Bcl6 Aifm2 Bax Ndrg1 Chm Trp73 Igfbp3 Nlrc4 Bnip3l Bid Triap1 Trp53 Cradd Trp63 Bcl2l14 Rabggta Slmo1 Rabggtb Crebbp Steap3 Atm Apaf1 Casp6 Casp1 Casp2 ELECTRON TRANSPORT FROM NADPH TO FERREDOXIN%REACTOME DATABASE ID RELEASE 59%2395516 Electron transport from NADPH to Ferredoxin Fdx1 Fdx1l Fdxr DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX%REACTOME DATABASE ID RELEASE 59%3769402 Deactivation of the beta-catenin transactivating complex Apc Ywhaz Sox13 Cby1 Ctnnb1 Akt2 Xpo1 Xiap Kmt2d Chd8 Btrc Ubc Hdac1 Akt1 Ctbp1 Pygo2 Pygo1 Tcf7l1 Bcl9l Tle3 Bcl9 Lef1 Tcf7 Sox2 Tle1 Tle4 Tle2 Sox7 Sox6 Sox9 Ash2l Sox4 Sox3 Rbbp5 Men1 Sox17 Ctnnbip1 Tcf7l2 FRUCTOSE CATABOLISM%REACTOME%R-HSA-70350.5 Fructose catabolism Aldob Glyctk Khk Tkfc Aldh1a1 FORMATION OF A POOL OF FREE 40S SUBUNITS%REACTOME DATABASE ID RELEASE 59%72689 Formation of a pool of free 40S subunits Rpl39 Rplp1 Eif3i Eif3k Eif3l Eif3m Rpl7 Rps21 Rplp2 Rps27 Eif3a Eif3b Eif3c Rps25 Rpl4 Eif3d Rps26 Rps27l Eif3e Rpl18a Rpl34 Rpl32 Eif3f Eif3h Eif3g Rpl26 Rpl24 Rps9 Rps7 Rps5 Rpsa Rpl37 Rps4x Rpl22 Eif1ax Rpl10l Rpl23 Rpl39l Eif3j2 Rpl13a Rpl22l1 Rps15a Rpl11 Rpl17 Rps3 Rpl19 Rpl18 Rps16 Rps14 Rps19 Rps18 Rps11 Rps10 TRANSPORT OF GAMMA-CARBOXYLATED PROTEIN PRECURSORS FROM THE ENDOPLASMIC RETICULUM TO THE GOLGI APPARATUS%REACTOME DATABASE ID RELEASE 59%159763 Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus Proz F10 Pros1 Gas6 F9 F2 F7 Proc SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX)%REACTOME DATABASE ID RELEASE 59%2162123 Synthesis of Prostaglandins (PG) and Thromboxanes (TX) Ptges2 Fam213b Ptgr2 Cbr1 Ptgis Ptgs1 Hpgd Akr1c18 Ptgs2 Ptgds Tbxas1 Ptges Hpgds Cyp8b1 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE%REACTOME DATABASE ID RELEASE 59%1660516 Synthesis of PIPs at the early endosome membrane Pik3c3 Pi4k2b Pik3c2a Pik3r4 Mtmr2 Mtm1 Pi4k2a Inpp5f Mtmr4 Inpp4b Inpp4a Pikfyve Fig4 Vac14 BETA OXIDATION OF BUTANOYL-COA TO ACETYL-COA%REACTOME DATABASE ID RELEASE 59%77352 Beta oxidation of butanoyl-CoA to acetyl-CoA Echs1 Acsm3 Hadh Acads PRC2 METHYLATES HISTONES AND DNA%REACTOME DATABASE ID RELEASE 59%212300 PRC2 methylates histones and DNA Hist1h2bg Suz12 Hist1h2bh Phf19 Dnmt3b Eed Hist1h2bp Phf1 Hist1h2bm Hist1h2bj Ezh2 Hist1h2bb Rbbp7 Aebp2 Hist2h3c1 H2afz Mtf2 Rbbp4 H2afx H2afj H2afb2 Dnmt1 Hist2h2aa1 Hist1h3d Hist1h2ak Hist3h2ba Hist2h2be Hist1h2ag Dnmt3a Hist2h2ac Jarid2 H3f3b H3f3a Hist1h2ah HOMOLOGY DIRECTED REPAIR%REACTOME DATABASE ID RELEASE 59%5693538 Homology Directed Repair Trex1 Rfc5 Rfc3 Rfc2 Rfc4 Rfc1 Pole Nbn Atrip Dna2 Pold1 Pold2 Bard1 Pold3 Pold4 Pole2 Rpa2 Rpa1 Mre11a Atm Hist2h2be Rpa3 Ube2i Rad17 Fen1 Pole4 Pole3 Hist1h2bg Hist1h2bh Hist1h2bp Rbbp8 Hist1h2bm Hist1h2bj Hist1h2bb Parp1 Rad1 Kat5 Ube2n Ppp4c Lig3 Fam175a Polh Pias4 Pcna Clspn Rnf168 Polk Ube2v2 Eme1 Cdk2 Brcc3 Trp53bp1 Ccna1 Rad50 Rad51b Uimc1 Rad51c Gen1 Ccna2 Tipin Babam1 Ppp4r2 Rnf4 Hist3h2ba Abl1 Top3a Ercc4 Rtel1 Ercc1 Brca2 Polq Chek1 Topbp1 Rad9a Blm Ubc Rad9b Hus1 Mdc1 H2afx Exo1 Brip1 Rad52 Herc2 Rad51 Timeless Spidr Bre Rad51ap1 Sirt6 Parp2 Slx4 Wrn Xrcc1 Mus81 Whsc1 Hist1h3h Brca1 Palb2 Xrcc3 Rad51d Xrcc2 ACTIVATION OF GABAB RECEPTORS%REACTOME%R-HSA-991365.1 Activation of GABAB receptors Gngt1 Adcy7 Gng7 Adcy6 Adcy5 Gng4 Adcy4 Adcy3 Kcnj10 Adcy2 Gngt2 Kcnj3 Adcy1 Gng10 Kcnj16 Kcnj15 Adcy9 Adcy8 Kcnj6 Gnai2 Gnai1 Kcnj5 Kcnj9 Gnai3 Gnat3 Gnal Gabbr2 Gabbr1 Kcnj2 Gng12 Kcnj12 Gnb2 Gnb1 Kcnj4 Gnb3 Gng8 Gng3 Gng2 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING%REACTOME%R-HSA-1358803.1 Downregulation of ERBB2:ERBB3 signaling Usp8 Ubc Nrg2 Nrg1 Akt2 Erbb2 Akt3 Akt1 Rnf41 NEURONAL SYSTEM%REACTOME%R-HSA-112316.5 Neuronal System Kcnj8 Akap5 Abcc9 Grip1 Cacng8 Gria2 Grip2 Slc1a3 Cacng4 Slc1a2 Cacng3 Akap9 Dnajc5 Cacng2 Slc1a7 Myo6 Slc1a6 Tspan7 Pick1 Slc38a2 Slc1a1 Panx1 Gria3 Slc18a3 Panx2 Gria4 Gjd2 Gad1 Prkcb Arl6ip5 Naaa Gad2 Slc32a1 Kcnv2 Kcnv1 Kcna10 Kcnj1 Kcnh8 Kcnf1 Cacna1b Kcnh7 Kcnh6 Cacfd1 Kcnq5 Kcns1 Kcng4 Kcng1 Kcna7 Kcng3 Kcnc4 Kcnc3 Slc6a12 Kcnh4 Kcnh5 Kcnab3 Kcnh3 Kcnab1 Kcnb2 Kcnq4 Kcns2 Slc6a11 Hspa8 Kcna1 Dlg1 Kcnq3 Kcna3 Kcna2 Kcna4 Kcnh1 Kcna5 Ap2a1 Dlg3 Kcnc1 Kcnq2 Slc22a2 Slc22a1 Rps6ka6 Slc5a7 Rps6ka3 Rps6ka2 Rps6ka1 Slc6a4 Lrfn2 Lrfn3 Gnat3 Slc6a1 Arhgef9 Slc6a13 Ptprf Flot2 Gja10 Gjc1 Aldh2 Flot1 Lrfn4 Rtn3 Adcy7 Adcy6 Adcy5 Adcy4 Adcy3 Adcy2 Adcy1 Slc38a1 Rasgrf1 Adcy9 Adcy8 Raf1 Kcnb1 Kcnab2 Kcns3 Kcng2 Kcnc2 Syt10 Dlgap4 Nlgn3 Syt12 Dlgap1 Apba2 Dlgap3 Dlgap2 Shank1 Grik2 Dlg2 Shank3 Nrxn2 Abat Nlgn1 Gnal Nlgn2 Gabbr2 Dbnl Homer3 Aldh5a1 Gabbr1 Syt9 Syt7 Nrxn1 Epb4.1 Begain Grik1 Syt2 Kcnh2 Kcnq1 Plcb1 Plcb2 Snap25 Epb4.1l3 Stxbp1 Epb4.1l2 Epb4.1l5 Grm1 Sipa1l1 Grm5 Kcnd3 Lrrtm3 Sharpin Kcnd2 Lrrtm1 Lrrtm2 Kcnd1 Pdlim5 Apba3 Mapk1 Homer1 Homer2 Cacnb2 Cacnb3 Cacna2d2 Kcnj11 Ppfia2 Ppfia1 Abcc8 Braf Apba1 Cacna2d3 Ppfia4 Plcb3 Syn3 Unc13b Syn1 Syn2 Rab3a Cacnb4 Cacnb1 Syt1 Slc18a2 Vamp2 Lin7c Cplx1 Lin7a Stx1a Actn2 Prkcg Prkca Gls2 Gria1 Kcnmb2 Kcnma1 Kcnmb4 Kcnmb1 Nsf Chat Nefl Grin2a Cacna1e Cacna1a Glul Rras Mdm2 Grik3 Comt Slc6a3 Maoa Gngt1 Gng7 Gng4 Gngt2 Gng10 Prkacb Hras Grin1 Kcnn2 Dlg4 Kcnn3 Kcnn1 Kcnn4 Kcna6 Gnai2 Chrnb2 Gnai1 Creb1 Kcnj5 Hcn4 Grin2c Gnai3 Kcnj9 Hcn3 Hcn1 Chrnb4 Hcn2 Chrnb3 Camk4 Gls Gng11 Gng13 Gng12 Gnb2 Gnb1 Gnb3 Gnb5 Ache Gnb4 Grin2d Prkaca Grin2b Gng8 Gng3 Gng2 Gabrr2 Gabrr3 Gabrb2 Gabrr1 Camkk1 Kcnj10 Gabrq Kcnj3 Chrnd Gabra2 Kcnj16 Kcnj15 Camk2d Chrng Camk2a Gabra5 Gabra1 Camk2b Gabra6 Chrna9 Gabra3 Chrne Gabra4 Chrna4 Cask Grik5 Chrna5 Grik4 Chrna3 Chrna1 Camk2g Chrna6 Chrna7 Kcnj6 Gabrg2 Gabrg3 Chrna2 Lin7b Bche Kcnk1 Kcnj2 Kcnj12 Kcnk9 Pdpk1 Kcnj4 Kcnk7 Kcnk6 Kcnk2 Kcnk13 Kcnk3 Kcnk10 Ncald Kcnk4 Kcnk18 Ptprs Kcnk16 Gabrb3 Kcnj14 Gabrb1 DEPOLARIZATION OF THE PRESYNAPTIC TERMINAL TRIGGERS THE OPENING OF CALCIUM CHANNELS%REACTOME%R-HSA-112308.2 Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels Cacna2d3 Cacng4 Cacna1b Cacnb2 Cacfd1 Cacng2 Cacnb4 Cacnb3 Cacnb1 Cacna2d2 Cacna1e Cacna1a MET ACTIVATES PTK2 SIGNALING%REACTOME%R-HSA-8874081.1 MET activates PTK2 signaling Lama5 Lama2 Lama4 Lamc1 Itgb1 Itga3 Lamb3 Src Lama1 Lamc3 Lamb2 Met Lamb1 Lama3 Itga2 Ptk2 Hgf Lamc2 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA)%REACTOME DATABASE ID RELEASE 59%400206 Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) Nfyb Nfyc Cyp7a1 Helz2 Mtf1 Srebf2 Cdk8 Nr1h4 Nrf1 Thrap3 Nfya Arntl Apoa2 Cyp4a32 Acsl1 Ahr Grhl1 Fhl2 Acadm Ep300 Apoa1 Ncoa3 Txnrd1 Med20 Med31 Glipr1 Med1 Nr1d1 Med27 Tbl1x Med26 Med30 Sult2a1 Agt Med23 Med24 Med25 Ctgf Cyp1a1 Med4 Arnt2 Med8 Med6 Havcr2 Fdft1 Med9 Rxra Carm1 Ugt1a9 Cd36 Sin3a Ahrr Tbl1xr1 Trib3 Abcb4 Fads1 Cdk19 Ccnc Tead3 Med13 Fam120b Med14 Tead1 Med12 Tead2 Sp1 Med10 Rgl1 Arnt Chd9 Clock Med16 Med17 Alas1 Med15 Tnfrsf21 Abca1 Esrra Rora Ncor1 Fabp1 Ncor2 Slc27a1 Crebbp Med13l Cpt2 Cpt1a Smarcd3 G0s2 Med22 Med28 Med29 Ppara Med21 Pparg Med11 Yap1 Me1 Med19 Ppargc1b Ankrd1 Ppargc1a Wwtr1 Apoa5 Tiam2 Hmgcs2 Plin2 Tead4 Med18 Ncoa1 Pex11a Npas2 Angptl4 Ncoa6 Ncoa2 Hdac3 DEUBIQUITINATION%REACTOME%R-HSA-5688426.3 Deubiquitination Rce1 Vdac1 Hist1h2aa Otud7a Ufd1l Adrm1 Vcp Ar Atxn7 Actb Foxo4 Hist1h2af Mat2b Asxl2 Vdac2 Asxl1 Trim25 Vdac3 Mavs Smad1 Tnip2 Nod2 Nod1 Zranb1 Hist3h2a Hcfc1 Hif1a Map3k7 Hist2h2ab Usp12 Ddb2 Usp11 Tab1 Smad4 Ripk2 Smad2 Usp19 Smad7 Usp13 Usp14 Mbd6 Smad3 Ide Usp16 Hist2h2bb Usp5 Nfkbia Stambpl1 Usp10 Hist2h2be Ep300 Uchl3 Hist2h2ac Tomm70a Usp3 Hist1h2bg Hist1h2bh Rnf135 Hist1h2bp Hist1h2bm Ino80 Rnf146 Ruvbl1 Hist1h2bj Otud3 Hist1h2bb Kdm1b Wdr20 Rnf123 Rnf128 Wdr48 Stambp Ino80c Ino80b Ino80e Ino80d Tnks Nfrkb Ptrh2 Tada3 Yod1 Foxk1 Foxk2 Polb Tnks2 Hist1h2ak Hist1h2ag Actl6a Trrap Tfpt Otub2 Actr8 Otub1 Actr5 Otud5 Hist1h2ah Usp9x Fam175a Clspn Psmf1 Psme4 Brcc3 Ccna1 Cdc25a Uimc1 Skp2 Ccna2 Psme3 Babam1 Usp7 Adrb2 Psma7 Psmb5 Psmb4 Ubc Psmb7 Myc Psmb6 Psmb2 Psmb3 Psmb1 Usp18 Bre Trp53 Psme2 Bap1 Psme1 Psmb10 Tgfbr1 Tgfbr2 Smurf2 Psmb11 Becn1 Usp8 Usp42 Usp44 Arrb2 Mdm4 Traf3 Usp47 Arrb1 Usp48 Usp49 Rhoa Siah2 Il33 Usp37 Usp33 Usp28 Usp30 Bard1 Suds3 Usp26 Stam Usp20 Hgs Usp25 Kat2b Kat2a Stam2 Usp22 Apc Axin1 Ripk1 Psmd12 Mysm1 Psmd11 Keap1 Fkbp8 Psmd14 Mul1 Psmd13 Psmd10 Gata3 Traf2 Ube2d1 Birc3 Birc2 Traf6 Cdc20 Shfm1 Ikbkg Mdm2 Park2 Josd2 Pten Atxn3 Senp8 Psmc6 Fam175b Psmc5 Ccp110 Psmc2 Psmd2 Psmb9 Psmb8 Psmc1 Psmc4 Psmc3 Yy1 Taf9b Rad23a Hist3h2ba Rad23b Esr1 Axin2 Tnfaip3 Usp21 Cftr Uchl1 Psma5 Otud7b Ifih1 Psma4 Psma3 Usp2 Psma6 Usp4 Cyld Psma2 Psma1 Psmd9 Tgfb1 Hist2h2aa1 Rhot1 Psmd1 Snx3 Uchl5 Nedd8 Brca1 Tnip1 Psmd3 Psmd4 Ogt Psmd6 Psmd5 Usp15 Psmd7 Nlrp3 Ddx58 Psmd8 Tnip3 DEFECTIVE C1GALT1C1 CAUSES TN POLYAGGLUTINATION SYNDROME (TNPS)%REACTOME DATABASE ID RELEASE 59%5083632 Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) Muc15 Muc20 Muc1 Muc4 Muc13 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME%REACTOME DATABASE ID RELEASE 59%975155 MyD88 dependent cascade initiated on endosome Irf7 Ppp2r1a Btrc Mapk9 Nfkb2 Nfkb1 Ecsit Fbxw11 Skp1a Saa3 Ppp2r5d Tlr8 Mapkapk3 Tlr7 Tnip2 Myd88 Nod2 Cul1 Nod1 Dhx9 Vrk3 S100b Elk1 Mef2c Mapk10 Mef2a Dusp3 Map3k7 Mapk7 Peli1 Creb1 Mapkapk2 Irak2 Irak1 App Map2k6 Tab1 Tab2 Jun Mapk8 Tab3 Map3k1 Ripk2 Map2k7 Dhx36 Ager Map2k3 Map2k4 Map3k8 Rela Atf2 Nfkbia Peli3 Nfkbib Irak4 Fos Peli2 Ppp2cb Map2k1 Chuk Tlr9 Ppp2ca Ubc Mapk3 Rps6ka5 Mapk1 Ppp2r1b Ticam2 Dusp7 Rps6ka3 Dusp6 Rps6ka2 Ticam1 Rps6ka1 Traf6 Ikbkb Ube2v1 Tlr4 Ube2n Tlr3 Ly96 Cd14 Ikbkg Mapk11 Mapk14 Dusp4 P75 NTR RECEPTOR-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 59%193704 p75 NTR receptor-mediated signalling Akap13 Ywhae Ect2 Itgb3bp Vav1 Nfkb1 Bad Hdac1 Rhoa Myd88 Rtn4 Aph1b Omg Hdac2 Irak1 Rac1 Mapk8 Ripk2 Ngef Arhgef10l Rela Arhgef26 Sos2 Fgd2 Net1 Nfkbia Prkci Fgd4 Fgd1 Trio Fgd3 Arhgef17 Arhgef10 Vav3 Gna13 Plekhg5 Arhgef19 Arhgef16 Arhgef15 Abr Arhgef18 Plekhg2 Arhgef40 Arhgef38 Casp3 Arhgef39 Mcf2 Ubc Mcf2l Arhgef37 Tiam2 Ngf Tiam1 Arhgef7 Arhgef11 Aatf Arhgef12 Prdm4 Traf6 Ikbkb Mag Arhgef3 Psen2 Arhgef4 Kalrn Arhgef1 Ncstn Arhgef2 Sqstm1 Vav2 Lingo1 Bcl2l11 Ngfrap1 Arhgef9 Sos1 Prex1 Arhgdia Arhgef6 Adam17 Casp2 Itsn1 Smpd2 Maged1 Ngfr Hdac3 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS%REACTOME%R-HSA-73817.3 Purine ribonucleoside monophosphate biosynthesis Adss Atic Ppat Pfas Paics Adssl1 Adsl Gart Impdh1 Lhpp Gmps ADRENALINE SIGNALLING THROUGH ALPHA-2 ADRENERGIC RECEPTOR%REACTOME%R-HSA-392023.1 Adrenaline signalling through Alpha-2 adrenergic receptor Adra2a Adra2c Adra2b NCAM1 INTERACTIONS%REACTOME%R-HSA-419037.1 NCAM1 interactions Gfra2 Agrn Pspn Col4a5 Gfra4 St8sia2 Artn Col9a1 Nrtn Col9a2 Col9a3 Cacna1s Cntn2 Ncan Gfra1 Cacna1i Cacna1h Cacna1g Prnp Cacnb2 Cacnb3 Cacna1c Gdnf Cacna1d Ncam1 Col4a3 Col4a2 Col4a4 Col4a1 Col6a1 Col6a2 St8sia4 Cacnb4 Col6a3 Cacnb1 Col6a6 EXTRACELLULAR MATRIX ORGANIZATION%REACTOME%R-HSA-1474244.2 Extracellular matrix organization Cd151 Agrn Itga6 Itga7 Itga8 Tnr Phykpl Serpine1 Tgfb3 Tgfb2 Lum Tnn Col3a1 Adamts14 Itga3 F11r Lamc3 Actn1 Col17a1 Lama3 Col1a2 Col1a1 Capn15 Capn7 Capn5 Lamc1 Capn8 Capn9 Timp1 Col16a1 Col15a1 Psen1 Casp3 Icam1 Lamb1 Itgav Itgae Itgad Itga11 Nid2 Jam2 Jam3 Mmp13 Mmp14 Adamts4 Adamts1 Mmp17 Mmp15 Mmp11 Mmp12 Mmp16 Lama1 Adam9 Cma1 Adamts8 Col26a1 Elane Mmp10 Adam8 Tmprss6 Mmp20 Mmp25 Mmp24 Adamts18 Col12a1 P4hb Adamts16 Col13a1 Itga1 Itga2 Capn11 Capn13 Capn10 Itga9 Col14a1 Capn6 Itga10 Adam15 Capn3 Itga5 Col18a1 Capn1 Fgf2 Cast Capns1 Capn2 Capns2 Furin Nrxn1 Bsg Adam10 Itga4 Itgb7 Itgal Tll1 Loxl4 Loxl3 Ddr2 Pcolce Tll2 Vcam1 Dmd Loxl2 Ntn4 Loxl1 Lox Bmp1 Ncam1 Col6a1 Col6a2 Col6a3 Pdgfa Col6a6 Ddr1 Adam17 Plg Prkca Mmp2 Mmp9 Col4a5 Bgn Dcn Fgg Bcan Pdgfb Col9a1 Col9a2 Ttr Col9a3 Itgb2 Ctrb1 Itgam Ncan Prss2 Kdr Vcan Trappc4 Col7a1 Ltbp2 Itgb4 Ltbp4 Mfap1b Itgb1 Ltbp3 Gdf5 Efemp2 Ltbp1 Fbn1 Efemp1 Plod3 Col28a1 Plod2 Plod1 Icam4 Icam5 Pcolce2 Col24a1 Col20a1 P3h3 Col27a1 P4ha2 P4ha3 Col10a1 P4ha1 Itgb3 Crtap Colgalt1 Colgalt2 Spp1 Col11a1 Serpinh1 Col11a2 P3h2 P3h1 Col8a1 Col8a2 Col5a1 Ppib Col22a1 Col4a6 Col5a3 Col5a2 Adamts3 Col4a3 Col4a2 Fbn2 Eln A2m Col4a4 Bmp4 Col4a1 Bmp2 Mfap2 Fga Col2a1 Adamts2 Fgb Mfap3 Mfap5 Bmp7 Thbs1 Bmp10 Mfap4 Itgb8 Fbln1 Fbln2 Fbln5 Icam2 Cdh1 Itga2b Cask Pecam1 Sdc3 Lama5 Mmp1a Plec Sdc4 Lama2 Optc Col25a1 Lama4 Nid1 Matn1 Sdc2 Timp2 Tnc Tgfb1 Sdc1 Ctss Col23a1 Musk Lamb3 Klk7 Dmp1 Hapln1 Ctsg Ctsb Lamb2 Ctsk Ncstn Dag1 Ctsl Itgax Fmod Mmp19 Matn4 Adamts5 Fn1 Matn3 Ctsd Klkb1 Aspn Sparc Itgb6 Itgb5 Vtn Lrp4 Ibsp Dspp Tnxb Mmp3 Htra1 Tpsb2 Cd44 Comp Col19a1 Spock3 Ptprs Hspg2 Mmp8 Lamc2 Cd47 Mmp7 DETOXIFICATION OF REACTIVE OXYGEN SPECIES%REACTOME%R-HSA-3299685.4 Detoxification of Reactive Oxygen Species Gpx7 Gpx8 Atox1 Gpx3 Gpx5 Txn2 Txn1 Sod3 Nox4 Prdx3 Prdx2 Prdx1 Txnrd2 Gpx6 Ccs Nudt2 Ncf4 Sod2 Atp7a Cat Ncf2 Gpx1 Ncf1 Cybb Cyba Gpx2 Ero1l P4hb Aqp8 Prdx6 Txnrd1 HEDGEHOG LIGAND BIOGENESIS%REACTOME%R-HSA-5358346.1 Hedgehog ligand biogenesis Psmc6 Disp2 Psmc5 Psmc2 Vcp Os9 Psmd2 Derl2 Psmb9 Psmf1 Psmb8 Psme4 Syvn1 Sel1l Psmc1 Psmc4 Psmc3 Psme3 Ihh Shh Dhh Notum Psmd12 Psma7 Psmd11 Psmd14 Psma5 Psmb5 Psmb4 Ubc Psmd13 Psmd10 Psma4 Psmb7 Psma3 Psma6 Psmb6 Psmb2 Psmb3 Psmb1 Psma2 Psma1 Psmd9 Gpc5 Psmd1 Shfm1 Psme2 Psme1 Psmd3 Psmd4 Psmb10 Psmd6 Psmd5 P4hb Psmd7 Hhat Adam17 Psmb11 Psmd8 Erlec1 EGFR DOWNREGULATION%REACTOME%R-HSA-182971.4 EGFR downregulation Spry2 Egf Arhgef7 Ptpn12 Sh3kbp1 Ubc Egfr Cbl Ptprk Sh3gl2 Eps15l1 Epn1 Sh3gl1 Stam Hgs Spry1 Stam2 Eps15 INACTIVATION OF CDC42 AND RAC%REACTOME DATABASE ID RELEASE 59%428543 Inactivation of Cdc42 and Rac Srgap2 Robo1 Arhgap39 Rac1 Slit2 Srgap3 Gpc1 Srgap1 MITOCHONDRIAL TRANSLATION INITIATION%REACTOME%R-HSA-5368286.1 Mitochondrial translation initiation Mrps14 Mrps11 Mrps16 Mrpl41 Mrps9 Mrps15 Mrpl28 Mrps17 Mrpl35 Mtif3 Dap3 Gadd45gip1 Mrps10 Eral1 Mrps12 Mrpl40 Mrpl38 Mrps5 Mrpl39 Mrps2 Mrpl32 Mrpl33 Mtif2 Mrpl34 Mrpl36 Mrps6 Mrpl37 Mrps7 Mrps34 Mrpl20 Mrps31 Mrps30 Mrpl1 Mrpl16 Mrpl2 Mrpl17 Mrpl14 Mrpl3 Mrpl4 Mrpl12 Mrpl13 Mrpl10 Mrpl11 Mrpl9 Mrpl55 Mrpl57 Mrpl19 Mrpl18 Chchd1 Mrpl54 Mrpl30 Ptcd3 Mtfmt Mrps18a Mrpl22 Mrpl21 Mrps18b Mrps18c Mrpl24 Mrpl51 Mrps23 Mrps22 Mrpl50 Mrps25 Mrpl53 Mrps24 Mrpl52 Mrps28 Aurkaip1 Mrps26 Mrps27 Mrps21 Mrpl47 Mrpl48 Ict1 Mrpl46 Mrpl43 Mrpl44 Mrpl49 Mrps33 Mrps35 Mrpl45 INSULIN-LIKE GROWTH FACTOR-2 MRNA BINDING PROTEINS (IGF2BPS IMPS VICKZS) BIND RNA%REACTOME DATABASE ID RELEASE 59%428359 Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs IMPs VICKZs) bind RNA Igf2bp1 Igf2bp3 Igf2bp2 CASP8 ACTIVITY IS INHIBITED%REACTOME DATABASE ID RELEASE 59%5218900 CASP8 activity is inhibited Fas Casp8 Fadd Tradd Fasl Ripk1 Tnfrsf10b Tnfsf10 Traf2 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES%REACTOME DATABASE ID RELEASE 59%2022090 Assembly of collagen fibrils and other multimeric structures Cd151 Itgb4 Itga6 Col24a1 Col27a1 Col10a1 Col3a1 Col11a1 Col11a2 Col8a1 Col8a2 Col5a1 Col4a6 Col5a3 Col5a2 Col4a3 Col4a2 Mmp9 Col4a4 Col4a1 Col2a1 Lama3 Col1a2 Col1a1 Col4a5 Col15a1 Col9a1 Col9a2 Col9a3 Mmp13 Tll1 Plec Loxl4 Loxl3 Pcolce Ctss Tll2 Loxl2 Col7a1 Lamb3 Loxl1 Lox Ctsb Bmp1 Ctsl Mmp20 Col6a1 Col6a2 Col6a3 Mmp3 Col6a6 Lamc2 Col18a1 Mmp7 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS%REACTOME DATABASE ID RELEASE 59%674695 RNA Polymerase II Pre-transcription Events Gtf2a1 Gtf2a2 Cdk9 Gtf2b Taf1 Taf2 Taf4b Taf7 Taf4a Taf5 Supt6 Taf6 Taf3 Polr2f Polr2i Gtf2e1 Polr2e Polr2j Nelfa Polr2h Gtf2e2 Tbp Nelfb Rtf1 Polr2c Mnat1 Ell Polr2d Supt4a Polr2b Taf9b Mllt1 Aff4 Taf9 Mllt3 Polr2g Polr2k Ccnt1 Ctdp1 Ssrp1 Polr2a Wdr61 Nelfe Supt5 Nelfcd Gtf2h1 Gtf2f1 Ccnt2 Ncbp1 Ncbp2 Gtf2h2 Gtf2f2 Gtf2h5 Taf13 Gtf2h4 Paf1 Taf11 Eaf1 Gtf2h3 Ercc3 Ctr9 Taf12 Cdc73 Ercc2 Ak6 Tcea1 Tceb1 Iws1 Tceb3 Supt16 Ccnh Ccnk Leo1 Cdk7 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING%REACTOME%R-HSA-451326.1 Activation of Kainate Receptors upon glutamate binding Gngt1 Gng7 Gng4 Gngt2 Dlg1 Gng10 Plcb1 Plcb2 Dlg3 Dlg4 Grik5 Grik4 Grik2 Gng11 Gng13 Gng12 Gnb2 Gnb1 Plcb3 Gnb3 Gnb5 Gnb4 Grik1 Grik3 Gng8 Ncald Gng3 Gng2 P53-INDEPENDENT DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 59%69610 p53-Independent DNA Damage Response Psmc6 Psmc5 Psmc2 Psmd2 Psmb9 Psmb8 Psmf1 Psme4 Psmc1 Psmc4 Psmc3 Cdc25a Psme3 Chek2 Atm Chek1 Psmd12 Psmd11 Psma7 Psmd14 Psma5 Psmb5 Psmb4 Psmd13 Ubc Psmd10 Psma4 Psma3 Psmb7 Psma6 Psmb6 Psmb2 Psmb3 Psma2 Psmb1 Psma1 Psmd9 Psmd1 Psme2 Shfm1 Psme1 Psmd3 Psmd4 Psmb10 Psmd6 Psmd5 Psmd7 Psmb11 Psmd8 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING%REACTOME%R-HSA-512988.2 Interleukin-3, 5 and GM-CSF signaling Akap9 Ppp2r1a Csf2 Jak1 Frs2 Nras Frs3 Rasgrf1 Psmf1 Raf1 Psme4 Il5ra Fgf1 Il17rd Fgf2 Cnksr1 Csk Cnksr2 Erbb2 Fgf9 Ptk2 Fgf7 Psme3 Fgf6 Fgf4 Fgf3 Ppp5c Ranbp9 Ppp2cb Shc1 Lamtor2 Nrg2 Ppp2ca Shc3 Nrg1 Shc2 Psma7 Artn Nrtn Brap Gab2 Psmb5 Psmb4 Ubc Nrg3 Psmb7 Nrg4 Psmb6 Psmb2 Psmb3 Psmb1 Mapk3 Mapk1 Ksr1 Ptpra Dusp16 Dusp10 Map3k11 Paqr3 Psme2 Psme1 Ncam1 Sos1 Braf Psmb10 Apbb1ip Rapgef1 Psmb11 Csf2rb2 Tec Rapgef2 Csf2ra Actn2 Nf1 Pdgfrb Stat5b Pdgfra Stat5a Kbtbd7 Vav1 Il2rg Arrb2 Egfr Arrb1 Ret Vwf Sptan1 Pspn Map2k1 Rbx1 Crkl Fgg Map2k2 Cul3 Psmd12 Pdgfb Psmd11 Rasgef1a Yes1 Psmd14 Lyn Rasa3 Rasa4 Psmd13 Cbl Psmd10 Inppl1 Il2 Rasa2 Rasa1 Nefl Spred3 Kit Spred2 Grin2a Spred1 Spta1 Il5 Sptbn4 Ppp2r1b Ywhab Kras Gdnf Shfm1 Irs2 Syngap1 Hbegf Irs1 Ptpn6 Il3ra Btc Il2ra Il2rb Angpt1 Ptpn11 Psmc6 Egf Fgf23 Psmc5 Fgf22 Mark3 Psmc2 Fgf20 Psmd2 Dab2ip Tek Psmb9 Psmb8 Araf Hras Grin1 Ppp2r5e Dlg4 Ppp2r5c Ppp2r5d Ppp2r5a Psmc1 Psmc4 Psmc3 Pik3cb Sptbn2 Pik3cd Sptbn1 Itgb3 Fyn Hck Phb Grin2c Rasgrp4 Rasgrp3 Inpp5d Pebp1 Blnk Ppp2r5b Rasgrp1 Syk Tln1 Pik3ca Fga Fgb Grin2d Prkaca Grin2b Sptb Hgf Gfra2 Gfra3 Gfra4 Ywhaz Ereg Jak2 Pea15a Itga2b Rap1a Jak3 Wdr83 Camk2d Rap1b Camk2a Fgfr4 Camk2b Psma5 Rasal3 Rasal2 Psma4 Psma3 Psma6 Vcl Camk2g Psma2 Psma1 Gfra1 Psmd9 Dusp7 Iqgap1 Fgf16 Dusp6 Dusp9 Fgf15 Dusp8 Klb Fgf18 Psmd1 Met Fn1 Rasal1 Dusp1 Psmd3 Psmd4 Psmd6 Psmd5 Dusp2 Pik3r3 Psmd7 Crk Pik3r1 Dusp5 Psmd8 Fgf10 Pik3r2 Dusp4 INHIBITION OF HSL%REACTOME%R-HSA-164928.2 Inhibition of HSL Pde3b Akt2 NETRIN MEDIATED REPULSION SIGNALS%REACTOME DATABASE ID RELEASE 59%418886 Netrin mediated repulsion signals Fyn Ntn1 Unc5b Dcc Ptk2 Unc5c Ptpn11 Unc5d Unc5a INTRAFLAGELLAR TRANSPORT%REACTOME%R-HSA-5620924.3 Intraflagellar transport Ift81 Ift80 Kif3c Wdr34 Kif3b Tctex1d2 Kif3a Trip11 Tctex1d1 Ttc30b Dynll2 Ift43 Ift46 Wdr60 Kif17 Ift74 Dynlrb1 Ift140 Ift122 Dynlrb2 Ift52 Ift172 Ttc26 Ift57 Wdr19 Gm3448 Ttc21b Dync2h1 Dync2li1 Wdr35 Dynll1 Ift88 Tcte3 Ttc30a1 Kifap3 Hspb11 Ift27 Traf3ip1 Cluap1 Tnpo1 Ift22 MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS%REACTOME%R-HSA-174490.2 Membrane binding and targetting of GAG proteins Ubc Vps37d Tsg101 Vps37c Vps37b Nmt2 Vps37a Tonsl UNCOATING OF THE INFLUENZA VIRION%REACTOME DATABASE ID RELEASE 59%168336 Uncoating of the Influenza Virion TFAP2 (AP-2) FAMILY REGULATES TRANSCRIPTION OF CELL CYCLE FACTORS%REACTOME DATABASE ID RELEASE 59%8866911 TFAP2 (AP-2) family regulates transcription of cell cycle factors Tfap2a Kdm5b Myc Tfap2c Cdkn1a LIGAND-INDEPENDENT CASPASE ACTIVATION VIA DCC%REACTOME%R-HSA-418889.1 Ligand-independent caspase activation via DCC Casp3 Casp9 Dapk2 Unc5b Dcc Dapk3 Maged1 Dapk1 Appl1 Unc5a LAMININ INTERACTIONS%REACTOME%R-HSA-3000157.1 Laminin interactions Lama5 Itgb4 Itga6 Itga7 Lama2 Lamc1 Lama4 Itgb1 Nid1 Itga3 Lamb3 Lama1 Lamc3 Lamb2 Lamb1 Itga1 Lama3 Itga2 Itgav Nid2 Hspg2 Lamc2 Col18a1 VISUAL PHOTOTRANSDUCTION%REACTOME DATABASE ID RELEASE 59%2187338 Visual phototransduction Agrn Gngt1 Akr1c6 Ldlr Lrp1 Bco1 Prkca Bco2 Akr1c18 Apoa4 Akr1c21 Apoa2 Apom Rho Rdh11 Pnlip Pde6a Gucy2e Rcvrn Gnb1 Pde6b Gucy2f Opn1sw Cnga1 Rgs9bp Fntb Guca1a Sag Guca1b Ppef1 Apoa1 Metap2 Apob Metap1 Clps Grk1 Pde6g Napepld Camkmt Lrat Apoc2 Apoc3 Rdh12 Abca4 Rlbp1 Rdh5 Gpihbp1 Stra6 Cyp4v3 Hsd17b1 Dhrs3 Ttr Rdh10 Lpl Slc24a1 Prkcq Nmt2 Nmt1 Apoe Sdc3 Rbp2 Sdc4 Gpc6 Rbp1 Sdc2 Fnta Gpc3 Sdc1 Gpc5 Akr1b10 Gpc2 Rbp4 Opn1mw Gnat1 Gpc4 Rpe65 Myo7a Dhrs9 Hsd17b6 BC089597 Rbp3 Rdh8 Sdr9c7 Lrp2 Plb1 Lrp12 Hspg2 Lrp10 Gpc1 GLYCOGEN STORAGE DISEASES%REACTOME DATABASE ID RELEASE 59%3229121 Glycogen storage diseases Ppp1r3c Ubc Gys2 Gys1 Gyg Epm2a PKA ACTIVATION%REACTOME%R-HSA-163615.1 PKA activation Adcy7 Adcy6 Adcy5 Adcy4 Adcy3 Adcy2 Prkar2a Adcy1 Prkacb Adcy9 Adcy8 Prkar2b Prkar1a Prkar1b Prkaca FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION%REACTOME DATABASE ID RELEASE 59%434316 Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Plcb3 Gna11 Gnaq Plcb1 Gna15 Plcb2 Ffar1 Gna14 MITOTIC PROMETAPHASE%REACTOME%R-HSA-68877.2 Mitotic Prometaphase Zw10 Ska1 Nup85 Pmf1 Nup160 Spc25 Nudc Ppp2r1a Rps27 Spc24 Xpo1 Clasp2 Itgb3bp Nuf2 Ncaph Cenpf Ppp1cc Cenpq Cenpp Ahctf1 Cenpm Cenpl Cenpo Smc4 Clip1 Cenpn Aurkb Smc2 Zwilch Cdca8 Cenpt Ncapd2 Sec13 Apitd1 Stag2 Sgol2b Ercc6l Stag1 Dsn1 Nup107 Mad1l1 Smc1a Rad21 Cenph Cenpi Cenpe Cenpk Kif2c Taok1 Birc5 Kif2b Kif18a Csnk2a2 Bub1b Zwint Nup37 Incenp Wapal Nup43 Nup133 Rcc2 Nsl1 Kif2a Ndel1 Spdl1 Ndc80 Kntc1 Bub3 Cdca5 Bub1 Cenpu Mad2l1 Casc5 Smc3 Cenpa Cenpc1 Ppp2r1b Cdc20 Csnk2b Sgol1 Pds5a Ranbp2 Mis12 Pds5b Pafah1b1 B9d2 Ppp2r5e Ppp2r5c Cdk1 Ppp2r5d Ppp2r5a Ccnb2 Clasp1 Ppp2r5b Mapre1 Ppp2cb Ckap5 Ppp2ca Plk1 CLEAVAGE OF THE DAMAGED PURINE%REACTOME DATABASE ID RELEASE 59%110331 Cleavage of the damaged purine Ogg1 Mpg Mutyh SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1%REACTOME%R-HSA-1839122.1 Signaling by activated point mutants of FGFR1 Fgf1 Fgf23 Fgf2 Fgf20 Fgfr1 Fgf9 Fgf6 Fgf4 ADHERENS JUNCTIONS INTERACTIONS%REACTOME DATABASE ID RELEASE 59%418990 Adherens junctions interactions Cadm3 Jup Ctnnd1 Cdh1 Cdh2 Cdh3 Cdh4 Cdh5 Cdh6 Cdh8 Cdh7 Cdh9 Ang Ctnna1 Pvrl4 Cadm2 Cadm1 Pvrl1 Pvrl2 Pvrl3 Cdh24 Cdh17 Cdh10 Cdh13 Cdh12 Cdh15 Cdh11 S33 MUTANTS OF BETA-CATENIN AREN'T PHOSPHORYLATED%REACTOME%R-HSA-5358747.1 S33 mutants of beta-catenin aren't phosphorylated Ppp2cb Ppp2r1b Apc Axin1 Ppp2ca Amer1 Csnk1a1 Ctnnb1 Gsk3b Ppp2r1a Ppp2r5b Ppp2r5e Ppp2r5c Ppp2r5d Ppp2r5a NEF MEDIATED CD8 DOWN-REGULATION%REACTOME DATABASE ID RELEASE 59%182218 Nef Mediated CD8 Down-regulation Ap2a2 Ap2m1 Cd8b1 Ap2b1 Ap2s1 Ap2a1 Atp6v1h TRANSPORT OF GLYCEROL FROM ADIPOCYTES TO THE LIVER BY AQUAPORINS%REACTOME DATABASE ID RELEASE 59%432030 Transport of glycerol from adipocytes to the liver by Aquaporins Aqp9 Aqp7 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS%REACTOME%R-HSA-2173782.1 Binding and Uptake of Ligands by Scavenger Receptors Alb Lrp1 Calr Hbb-bs Hsp90aa1 Saa3 Stab2 Apoe Stab1 Col3a1 Hsp90b1 Fth1 Scgb3a2 Ftl1 Colec11 Colec12 Marco Hba-a1 Hyou1 Sparc Scarf1 Col4a2 Cd36 Jchain Ambp Hsph1 Col4a1 Cd163 Hpx Hp Scara5 Col1a2 Hbb-bt Col1a1 Apoa1 Apob Msr1 P38MAPK EVENTS%REACTOME%R-HSA-171007.1 p38MAPK events Mapk13 Mapkapk2 Mapk12 Mapk14 Ralgds Kras Mapkapk3 Nras Ralb Rala Mapk11 Hras DEGRADATION OF GLI1 BY THE PROTEASOME%REACTOME DATABASE ID RELEASE 59%5610780 Degradation of GLI1 by the proteasome Psmc6 Psmc5 Psmc2 Psmd2 Prkacb Psmb9 Psmb8 Psmf1 Psme4 Btrc Skp1a Psmc1 Psmc4 Psmc3 Cul1 Psme3 Prkaca Rbx1 Psmd12 Psma7 Psmd11 Psmd14 Psma5 Psmb5 Psmb4 Psmd13 Ubc Psmd10 Psma4 Itch Psma3 Psmb7 Psma6 Psmb6 Psmb2 Psmb3 Psmb1 Psma2 Psma1 Sufu Psmd9 Psmd1 Gli1 Shfm1 Psme2 Psme1 Psmd3 Psmd4 Numb Psmb10 Psmd6 Psmd5 Psmd7 Psmb11 Psmd8 MUSCARINIC ACETYLCHOLINE RECEPTORS%REACTOME DATABASE ID RELEASE 59%390648 Muscarinic acetylcholine receptors Chrm3 Chrm2 Chrm1 Chrm5 Chrm4 NUCLEOTIDE EXCISION REPAIR%REACTOME%R-HSA-5696398.2 Nucleotide Excision Repair Ppie Actb Ddb1 Ercc6 Rfc5 Rfc3 Rfc2 Rfc4 Rfc1 Polr2i Polr2j Ddb2 Pole Mnat1 Polr2c Polr2d Polr2b Pold1 Pold2 Pold3 Pold4 Polr2g Pole2 Cul4a Rpa2 Rpa1 Ep300 Rpa3 Polr2a Ube2i Lig1 Xab2 Pole4 Cul4b Pole3 Rbx1 Ino80 Ruvbl1 Ercc8 Prpf19 Zfp830 Ercc3 Parp1 Ercc2 Ino80c Ino80b Ino80e Ino80d Nfrkb Cops7b Cops7a Ube2n Aqr Uvssa Cops8 Cops6 Cops2 Cops4 Cops5 Cops3 Actl6a Tfpt Actr8 Actr5 Lig3 Pcna Pias3 Polk Ube2v2 Cetn2 Rnf111 Yy1 Polr2f Polr2e Polr2h Ell Sumo3 Isy1 Polr2k Chd1l Xpa Ercc5 Pias1 Usp7 Rad23a Usp45 Rad23b Xpc Ercc4 Gtf2h1 Ercc1 Gtf2h2 Gtf2h5 Gtf2h4 Gtf2h3 Ubc Tcea1 Parp2 Xrcc1 Ccnh Cdk7 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP)%REACTOME DATABASE ID RELEASE 59%400511 Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) Isl1 Dpp4 Gata4 Sec11c Sec11a Gpr119 Pcsk1 Spcs1 Gip Spcs2 Spcs3 Ffar1 Pax6 COLLAGEN FORMATION%REACTOME%R-HSA-1474290.1 Collagen formation Cd151 Itgb4 Itga6 Plod3 Col28a1 Plod2 Plod1 Pcolce2 Col24a1 Col20a1 P3h3 Col27a1 P4ha2 P4ha3 Col10a1 P4ha1 Col3a1 Crtap Colgalt1 Colgalt2 Col11a1 Serpinh1 Adamts14 Col11a2 P3h2 P3h1 Col8a1 Col8a2 Col5a1 Ppib Col22a1 Col4a6 Col5a3 Col5a2 Adamts3 Col4a3 Mmp9 Col4a2 Col4a4 Col17a1 Col4a1 Adamts2 Col2a1 Lama3 Col1a2 Col1a1 Col4a5 Col16a1 Col15a1 Col9a1 Col9a2 Col9a3 Mmp13 Tll1 Plec Col25a1 Loxl4 Loxl3 Pcolce Ctss Tll2 Lamb3 Col7a1 Col23a1 Loxl2 Loxl1 Lox Ctsb Bmp1 Ctsl Col26a1 Mmp20 Col6a1 Col12a1 Col6a2 P4hb Col13a1 Mmp3 Col6a3 Col6a6 Col14a1 Col19a1 Lamc2 Mmp7 Col18a1 TRNA PROCESSING IN THE NUCLEUS%REACTOME DATABASE ID RELEASE 59%6784531 tRNA processing in the nucleus Nup85 Rpp21 Nup160 Rpp25 Nup50 Tsen54 Fam98b Tpr Elac2 Ndc1 Nup214 Aaas Nup210 Nup188 Nup54 Nup35 Nupl2 Nup62 Nup205 Nup155 Nup88 Pom121 Trnt1 Rae1 2700060E02Rik Nup93 Nup153 Rtcb Cpsf1 Nup107 Clp1 Ran Nup37 Nup43 Cstf2 Nup133 Cpsf4 Rpp14 Tsen34 Pop4 Pop1 Pop7 Pop5 Tsen15 Xpot Rpp30 Rpp38 Tsen2 AI597479 Zbtb8os Rpp40 Ddx1 Ranbp2 CS DS DEGRADATION%REACTOME DATABASE ID RELEASE 59%2024101 CS DS degradation Hexa Bgn Dcn Bcan Arsb Ids Cspg4 Cspg5 Idua Hexb Ncan Hyal1 Vcan Hyal3 PAUSING AND RECOVERY OF TAT-MEDIATED HIV ELONGATION%REACTOME DATABASE ID RELEASE 59%167238 Pausing and recovery of Tat-mediated HIV elongation Cdk9 Polr2i Polr2f Polr2j Polr2e Nelfa Polr2h Nelfb Ell Polr2c Polr2d Supt4a Polr2b Tcea1 Tceb1 Tceb3 Supt16 Polr2k Polr2g Ccnt1 Ctdp1 Ssrp1 Polr2a Nelfe Supt5 Nelfcd Gtf2f1 Gtf2f2 PP2A-MEDIATED DEPHOSPHORYLATION OF KEY METABOLIC FACTORS%REACTOME%R-HSA-163767.2 PP2A-mediated dephosphorylation of key metabolic factors Ppp2cb Ppp2r1b Ppp2ca Ppp2r5d Ppp2r1a Mlxipl Pfkfb1 MEIOTIC RECOMBINATION%REACTOME DATABASE ID RELEASE 59%912446 Meiotic recombination Hist1h2bg Hist1h2bh Hist1h2bp Hist1h2bm Rbbp8 Hist1h2bj Hist1h2bb Hist2h3c1 Blm Spo11 Cdk2 Mnd1 Tex15 Msh5 Msh4 Rad50 H2afz Rad51c H2afx Cdk4 H2afj H2afb2 Rad51 Nbn Psmc3ip Hist2h2aa1 Dmc1 Mlh3 Hist1h3d Hist1h3h Brca1 Rpa2 Mre11a Hist1h2ak Rpa1 Atm Hist2h2be Hist3h2ba Hist1h2ag Rpa3 Top3a Hist2h2ac Mlh1 Prdm9 H3f3b H3f3a Brca2 Hist1h2ah METABOLISM OF FOLATE AND PTERINES%REACTOME DATABASE ID RELEASE 59%196757 Metabolism of folate and pterines Mthfr Slc19a1 Folr2 Aldh1l1 Slc25a32 Shmt2 Mthfd1l Shmt1 Slc46a1 Mthfsl Mthfd2l Mthfd2 Dhfr Mthfd1 Aldh1l2 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT%REACTOME DATABASE ID RELEASE 59%201681 TCF dependent signaling in response to WNT Dvl1 Sost Ccdc88c Dact1 Sox13 Cby1 Dvl3 Ppp2r1a Xpo1 Cxxc4 Chd8 Dvl2 Usp8 Btrc Znrf3 Rspo2 Lgr4 Rspo4 Rspo3 Hdac1 Lgr6 Rspo1 Lgr5 H2afj H2afb2 Wnt3 Wnt4 Wnt9a Sox2 Sox7 Sox6 Wif1 Sox9 Hecw1 Hist2h2be Sox4 Sox3 Ep300 Men1 Wnt8a Wnt8b Sox17 Hist2h2ac Ctnnbip1 Wnt5a Klhl12 Wnt1 H3f3b Ryk H3f3a Sfrp2 Sfrp1 Hist1h2bg Hist1h2bh Apc Rbx1 Tert Axin1 Amer1 Csnk2a2 Csnk1a1 Ctnnb1 Hist1h2bp Cul3 Hist1h2bm Psmd12 Rnf146 Psmd11 Ruvbl1 Hist1h2bj Smarca4 Xiap Hist1h2bb Psmd14 Psmd13 Psmd10 Cdc73 Ctbp1 Frat2 Pygo2 Ppp2r1b Tcf7l1 Pygo1 Tle3 Bcl9l Bcl9 Dkk1 Tnks Fzd6 Lef1 Dkk2 Tcf7 Kat5 Gsk3b Hist1h3d Tle1 Shfm1 Tle4 Csnk2b Tle2 Wnt3a Tnks2 Kremen2 Hist1h2ak Kremen1 Fzd2 Leo1 Hist1h2ag Fzd1 Dkk4 Trrap Fzd4 Fzd5 Fzd8 Lrp6 Tcf7l2 Hist1h2ah Lrp5 Rnf43 Psmc6 Psmc5 Psmc2 Psmd2 Psmb9 Psmf1 Psmb8 Kmt2d Psme4 Ppp2r5e Hist2h3c1 Ppp2r5c Ppp2r5d Ppp2r5a Psmc1 Psmc4 Psmc3 Psme3 Ppp2r5b Cav1 Csnk1e Crebbp Hist3h2ba Ppp2cb Ywhaz Ppp2ca Axin2 Akt2 Psma7 Psma5 Psmb5 Psmb4 Ubc Psma4 Psma3 Psmb7 Myc Psma6 Psmb6 H2afz Psmb2 Psmb3 H2afx Psma2 Psmb1 Psma1 Pip5k1b Akt1 Psmd9 Hist2h2aa1 Psmd1 Psme2 Csnk1g2 Hist1h3h Psme1 Psmd3 Psmd4 Psmb10 Psmd6 Psmd5 Ash2l Psmd7 Rbbp5 Smurf2 Psmb11 Psmd8 CHREBP ACTIVATES METABOLIC GENE EXPRESSION%REACTOME DATABASE ID RELEASE 59%163765 ChREBP activates metabolic gene expression Mlx Acly Acacb Acaca Fasn Agpat1 Mlxipl MISCELLANEOUS SUBSTRATES%REACTOME%R-HSA-211958.1 Miscellaneous substrates Cyp4a12b Cyp4f15 Cyp2s1 Cyp2u1 Cyp2w1 Cyp4b1 Cyp2d22 Cyp3a57 Cyp4f40 Cyp4a32 Cyp4f18 Cyp4f39 HDACS DEACETYLATE HISTONES%REACTOME DATABASE ID RELEASE 59%3214815 HDACs deacetylate histones Hist1h2aa Hist1h2af Sap30l Hist2h3c1 Hdac1 Arid4a Rbbp4 Rest Gps2 Chd3 Brms1 Chd4 Hist3h2a Hist2h2ab Hdac2 Ncor1 Sap30 Ncor2 Mbd3 Suds3 Arid4b Hist2h2bb Kdm1a Hdac10 Hist3h2ba Hist2h2be Mta1 Hist2h2ac Hdac8 Mta3 Hist1h2bg Hist1h2bh Gm10094 Tbl1x Hist1h2bp Hist1h2bm Rcor1 Hist1h2bj Rbbp7 Hist1h2bb Mta2 Hmg20b Hist2h2aa1 Gatad2a Gatad2b Hist1h3d Hist1h2ak Hist1h2ag Tbl1xr1 Hist1h2ah Hdac3 DEFECTIVE POMGNT1 CAUSES MDDGA3, MDDGB3 AND MDDGC3%REACTOME DATABASE ID RELEASE 59%5083628 Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3 Dag1 DUAL INCISION IN GG-NER%REACTOME DATABASE ID RELEASE 59%5696400 Dual Incision in GG-NER Gtf2h5 Gtf2h4 Rbx1 Pcna Ddb1 Polk Gtf2h3 Rfc5 Ercc3 Parp1 Rfc3 Ubc Rfc2 Rfc4 Rfc1 Ercc2 Ddb2 Pole Pold1 Parp2 Pold2 Pold3 Pold4 Chd1l Pole2 Xpa Cul4a Ercc5 Rpa2 Rpa1 Rpa3 Ercc4 Gtf2h1 Ercc1 Pole4 Cul4b Gtf2h2 Pole3 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY%REACTOME DATABASE ID RELEASE 59%3371599 Defective HLCS causes multiple carboxylase deficiency Mccc2 Mccc1 Pcca Pcx Acaca Pccb NEGATIVE REGULATION OF TCF-DEPENDENT SIGNALING BY DVL-INTERACTING PROTEINS%REACTOME%R-HSA-5368598.2 Negative regulation of TCF-dependent signaling by DVL-interacting proteins Dvl1 Ccdc88c Dvl3 Cxxc4 Dvl2 ION CHANNEL TRANSPORT%REACTOME DATABASE ID RELEASE 59%983712 Ion channel transport Scnn1b Glrb Trpc6 Scnn1a Ano8 Ano7 Scnn1g Ano5 Ano4 Atp8b2 Clcn5 Slc9b1 Clcn7 Slc9b2 Atp8b1 Clca4a Atp8a2 Ano6 Atp8b3 Ostm1 Pdzd11 Sgk3 Sgk2 Nedd4l Atp2c1 Tsc22d3 Trpc3 Atp4a Atp4b Stoml3 Atp2c2 Cutc Trpc7 Nalcn Atp6v0d2 Atp6v0d1 Atp6v0b Atp6v1c2 Atp6v1c1 Mcoln1 Atp6v0e Atp6ap1 Atp6v1g3 Atp6v1e2 Atp6v1e1 Atp6v0e2 Atp6v1a Atp6v1b1 Tcirg1 Atp6v1b2 Atp6v1g1 Atp6v1g2 Atp6v0a1 Atp6v0a2 Atp6v1h Atp6v0a4 Arhgef9 Atp6v1d Atp6v1f Slc9c1 Atp7b Best3 Best2 Clcn6 Best1 Raf1 Atp10b Atp11c Atp12a Atp13a5 Atp13a4 Atp13a2 Atp13a1 Bsnd Trpc1 Unc79 Atp9a Atp9b Atp10d Stom Clcn1 Atp10a Clcn2 Clcn3 Atp8a1 Fxyd7 Asic1 Asic4 Asic5 Gabrr2 Trpv1 Fxyd1 Gabrr3 Trpv3 Fxyd4 Gabrb2 Trpv2 Fxyd6 Gabrr1 Trpv4 Trpa1 Trpm2 Clca1 Trpc4 Gabrq Trpm1 Trpm7 Mcoln3 Sgk1 Gabra2 Mcoln2 Trpc5 Camk2d Trpm3 Atp1a1 Htr3a Trpm6 Camk2a Htr3b Gabra5 Trpm5 Gabra1 Trpm8 Camk2b Gabra6 Fkbp1b Gabra3 Atp1b2 Trpm4 Atp1a2 Trpc4ap Atp1a3 Atp7a Ubc Gabra4 Ttyh3 Wwp1 Atp1b3 Atp1b1 Camk2g Clca2 Gabrg2 Ryr3 Gabrg3 Ryr1 Ryr2 Slc17a3 Atp2a1 Trdn Atp2a3 Tpcn2 Atp2a2 Tpcn1 Ttyh2 Wnk4 Asph Wnk1 Wnk2 Wnk3 Glra1 Ano1 Atp2b3 Atp2b4 Glra4 Atp2b1 Clcn4-2 Ano2 Atp2b2 Ano10 Atp11a Clcnka Sri Clcnkb Atp11b Gabrb3 Glra3 Trpv6 Gabrb1 Glra2 Trpv5 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE%REACTOME DATABASE ID RELEASE 59%3359467 Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE Mtrr Mtr GLUTATHIONE SYNTHESIS AND RECYCLING%REACTOME DATABASE ID RELEASE 59%174403 Glutathione synthesis and recycling Oplah Ggt6 Ggt7 Gclm Chac2 Ggt1 Chac1 Cndp2 Gclc Gss Ggt5 EICOSANOIDS%REACTOME%R-HSA-211979.1 Eicosanoids Cyp4a12b Cyp4f15 Cyp4b1 Tbxas1 Cyp4f40 Cyp4a32 Cyp4f14 Cyp4f18 Cyp4f39 Cyp8b1 Cyp4f17 Ptgis INTERFERON SIGNALING%REACTOME DATABASE ID RELEASE 59%913531 Interferon Signaling Prkcd Nup85 Nup160 Isg15 Gbp9 Gbp5 Ube2l6 Gbp7 Trim25 Trim21 Ifitm2 Ifitm3 Arih1 Bst2 Uba7 Adar Nup107 H2-M3 H2-M5 2010002M12Rik Jak1 H2-Q1 Nup37 Pml Nup43 Trim26 Nup133 Ptafr Trim31 Tyk2 Icam1 Socs1 Ifnb1 Ube2n Ube2e1 H2-Aa Eif4e H2-Eb1 Ranbp2 Eif4g1 Ptpn6 Kpna3 Kpna4 Kpna7 Isg20 Ptpn11 Irf8 Irf7 Irf6 Mid1 Irf1 Irf4 Ppm1b Ifit2 Gbp2 Nup50 Gbp3 Tpr Psmb8 Irf2 Irf3 Trim12c Ndc1 Nup214 Aaas Nup210 Nup188 Nup54 Nup35 Pin1 Nupl2 Oasl1 Nup62 Nup205 Flnb Nup155 Nup88 Ifi35 Pom121 Ifi30 Ifna16 Irf9 Ifi27 Irf5 Rae1 Nup93 Stat1 Ciita Nup153 Trim68 Rsad2 Fcgr1 Pias1 Trim62 Trim46 Trim45 Egr1 Trim35 Trim38 Ifit3b Ptpn1 Jak2 Eif4a3 Rnasel Ifngr2 Camk2d Ifng Camk2a Plcg1 Camk2b Trim14 Ip6k2 Ubc Socs3 Samhd1 Ifngr1 Nedd4 Mt2 Trim17 Camk2g Oas1g Mapk3 Trim10 Trim6 Trim8 Eif4a1 Eif4a2 Trim3 Trim2 Usp18 Ifnar1 Stat2 Vcam1 Kpnb1 Oas2 Oas3 Ncam1 Kpna1 H2-Q10 Eif4g2 Eif4e3 Cd44 Eif4g3 Ddx58 B2m Eif2ak2 DISEASES ASSOCIATED WITH THE TLR SIGNALING CASCADE%REACTOME%R-HSA-5602358.1 Diseases associated with the TLR signaling cascade Chuk Ticam1 Ikbkb Tlr4 Btk Tlr2 Tlr6 Tlr3 Ly96 Cd14 Ikbkg Rela Nfkb2 Nfkbia Cd36 Traf3 Nfkb1 Nfkbib Irak4 Tlr1 Tirap Myd88 Tlr5 INOSITOL TRANSPORTERS%REACTOME DATABASE ID RELEASE 59%429593 Inositol transporters Slc2a13 Slc5a2 Slc5a3 Slc5a1 Slc5a11 Slc5a9 Slc5a4a CLATHRIN DERIVED VESICLE BUDDING%REACTOME DATABASE ID RELEASE 59%421837 Clathrin derived vesicle budding Golgb1 Pik3c2a Rab5c Ap3b1 Arrb1 Arf1 Fth1 Ftl1 App Hgs Ocrl Cltb Bloc1s4 Tbc1d8b Bloc1s3 Vamp8 Bloc1s6 Hspa8 Stx4a Necap1 Acbd3 Hip1r Picalm M6pr Dtnbp1 Cpd Chmp2a Pum1 Igf2r Gak Gbf1 Sh3gl2 Dnm2 Napa Tfrc Ctsz Ap4b1 Clvs1 Ap1g2 Clta Ap1s2 Clint1 Tpd52l1 Ap1b1 Bloc1s1 Cltc Ap1s1 Sort1 Ap1g1 Snap23 Snx2 Dnajc6 Ap3s1 Sh3d19 Yipf6 Snapin Ap1s3 Ap4e1 Vamp7 Ap4s1 Vamp2 Clvs2 Snx9 Txndc5 Ap4m1 Snx5 Ap1m2 Dnase2a Ap1m1 Gns BETA OXIDATION OF LAUROYL-COA TO DECANOYL-COA-COA%REACTOME DATABASE ID RELEASE 59%77310 Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA Echs1 Acadl Hadhb Hadha Hadh PHASE 2 - PLATEAU PHASE%REACTOME DATABASE ID RELEASE 59%5576893 Phase 2 - plateau phase Cacng8 Cacng6 Cacng1 Cacng4 Cacng5 Cacng3 Akap9 Kcnq1 Cacng2 Cacng7 Kcne1l Cacna1s Cacna1f Kcne4 Kcne3 Kcne2 Kcne1 Cacnb2 Cacnb3 Cacna2d2 Cacna1c Cacna1d Cacna2d1 Cacna2d4 Cacna2d3 Cacnb4 Cacnb1 RIBOSOMAL SCANNING AND START CODON RECOGNITION%REACTOME DATABASE ID RELEASE 59%72702 Ribosomal scanning and start codon recognition Eif2s1 Eif2s2 Eif3i Eif3k Eif3l Eif3m Rps21 Rps27 Eif3a Eif3b Eif4b Eif3c Rps25 Eif3d Eif5 Rps26 Rps27l Eif3e Eif3f Eif3h Eif3g Rps9 Eif2s3x Rps7 Rps5 Eif4a1 Eif4a2 Eif1ax Eif3j2 Rps15a Rps3 Rps16 Eif4e Rps14 Rps19 Rps18 Eif4h Rps11 Eif4g1 Rps10 Rpsa Rps4x ORGANIC ANION TRANSPORTERS%REACTOME DATABASE ID RELEASE 59%428643 Organic anion transporters Slc17a1 Slc5a5 Slc25a22 Slc5a8 Slc25a10 Slc17a5 Slc17a6 Slc25a18 Slc17a8 TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G1 CELL CYCLE ARREST%REACTOME DATABASE ID RELEASE 59%6804116 TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest E2f7 Cdkn1a Trp53 Arid3a Ccne1 Cdk2 Cdkn1b Ccne2 Pcbp4 E2f1 Ccna1 Ccna2 Zfp385a CELL CYCLE CHECKPOINTS%REACTOME DATABASE ID RELEASE 59%69620 Cell Cycle Checkpoints Ywhae Trex1 Rfc5 Mcm6 Ccne1 Mdm4 Rfc3 Mcm3 Mcm2 Mcm5 Ccne2 Mcm4 Rfc2 Rfc4 Orc4 Orc5 Mcm8 Mcm7 Nbn Atrip Cdc45 Dna2 Bard1 Orc2 Orc3 Orc6 Orc1 Chek2 Rpa2 Mre11a Rpa1 Atm Hist2h2be Rpa3 Mad1l1 Rad17 Hist1h2bg Hist1h2bh Bub1b Cdkn1a Hist1h2bp Hist1h2bm Psmd12 Rbbp8 Psmd11 Hist1h2bj Hist1h2bb Psmd14 Psmd13 Rad1 Bub3 Psmd10 Mad2l1 Cdc23 Ube2d1 Ywhab Cdc27 Cdc16 Cdc20 Kat5 Ube2c Anapc16 Ube2n Ube2e1 Anapc7 Anapc4 Shfm1 Anapc5 Anapc1 Rfwd2 Anapc2 Mdm2 Psmc6 Psmc5 Psmc2 Fam175a Psmd2 Pias4 Ywhag Clspn Psmb9 Psmf1 Psmb8 Rnf168 Psme4 Ube2v2 Cdc6 Cdk2 Cdk1 Brcc3 Rad50 Ccna1 Psmc1 Trp53bp1 Psmc4 Cdc25a Psmc3 Uimc1 Ccna2 Psme3 Anapc15 Anapc11 Babam1 Anapc10 Ccnb2 Gtse1 Pkmyt1 Cdkn1b Hist3h2ba Top3a Chek1 Wee1 Ywhaz Cdc25c Ywhah Sfn Topbp1 Psma7 Psma5 Rad9a Psmb5 Blm Psmb4 Ubc Psma4 Rad9b Psma3 Psmb7 Psma6 Hus1 Pcbp4 Psmb6 Cdc7 Psmb2 Mdc1 Psmb3 H2afx Psma2 Dbf4 Psmb1 Mcm10 Psma1 Exo1 Brip1 Zfp385a Psmd9 Herc2 Bre Trp53 Wrn Psmd1 Psme2 Whsc1 Hist1h3h Psme1 Brca1 Psmd3 Psmd4 Psmb10 Psmd6 Psmd5 Psmd7 Psmb11 Psmd8 REGULATION OF TP53 ACTIVITY THROUGH METHYLATION%REACTOME%R-HSA-6804760.1 Regulation of TP53 Activity through Methylation Smyd2 Trp53 Jmy Chek2 Ehmt2 Mdm4 Ubc Mdm2 Setd8 Atm Prmt5 Ep300 L3mbtl1 Ttc5 Ehmt1 NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY%REACTOME%R-HSA-168333.2 NEP NS2 Interacts with the Cellular Export Machinery Nup85 Nup160 Nup37 Nup50 Tpr Nup43 Nup133 Xpo1 Ndc1 Nup214 Aaas Nup210 Nup188 Nup54 Nup35 Nupl2 Nup62 Nup205 Nup155 Nup88 Pom121 Rae1 Nup93 Nup153 Ranbp2 Nup107 Ran RECOGNITION AND ASSOCIATION OF DNA GLYCOSYLASE WITH SITE CONTAINING AN AFFECTED PURINE%REACTOME DATABASE ID RELEASE 59%110330 Recognition and association of DNA glycosylase with site containing an affected purine Ogg1 Mpg Mutyh GLUCOSE TRANSPORT%REACTOME DATABASE ID RELEASE 59%70153 Glucose transport Hk1 Nup85 G6pc2 Nup160 Nup37 G6pc3 Nup50 Nup43 Tpr Nup133 Hk2 Ndc1 Nup214 Hk3 Aaas Nup210 Nup188 Nup54 Nup35 Nupl2 Slc2a4 Nup62 Slc2a3 Nup205 Nup155 Slc2a2 Nup88 Slc2a1 Slc37a4 Pom121 Slc45a3 Rae1 Fgf21 Nup93 Nup153 Gckr Slc50a1 G6pc Ranbp2 Nup107 Gck BILE ACID AND BILE SALT METABOLISM%REACTOME DATABASE ID RELEASE 59%194068 Bile acid and bile salt metabolism Alb Akr1c6 Acox2 Hsd17b4 Cyp7a1 Cyp7b1 Baat Acot8 Abcb11 Nr1h4 Stard5 Ptgis Ch25h Akr1c18 Akr1c21 Slco1a4 Osbpl1a Slco1b2 Cyp8b1 Abcc3 Osbp Osbpl3 Osbpl9 Osbpl6 Osbpl7 Fabp6 Rxra Osbpl2 Slc27a5 Cyp46a1 Cyp27a1 Akr1d1 Amacr Hsd3b7 Slc10a2 Slc10a1 Cyp39a1 Ncoa1 Ncoa2 Slc27a2 PLASMALOGEN BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 59%75896 Plasmalogen biosynthesis Agps Gnpat MITOPHAGY%REACTOME DATABASE ID RELEASE 59%5205647 Mitophagy Vdac1 Atg5 Sqstm1 Tomm6 Mfn2 Ubc Tomm7 Park2 Tomm22 Mterf3 Atg12 Pink1 Tomm70a Map1lc3a Tomm40 Map1lc3b Mfn1 POTASSIUM CHANNELS%REACTOME%R-HSA-1296071.1 Potassium Channels Gngt1 Kcnj8 Gng7 Abcc9 Gng4 Gngt2 Gng10 Kcnb1 Kcnab2 Kcns3 Kcnn2 Kcnn3 Kcnn1 Kcng2 Kcnn4 Kcnc2 Kcna6 Kcnv2 Kcnv1 Kcna10 Kcnh8 Kcnj1 Hcn4 Kcnj5 Hcn3 Kcnf1 Kcnj9 Kcnh7 Hcn1 Kcnh6 Hcn2 Gabbr2 Gabbr1 Kcnq5 Kcns1 Gng12 Kcng4 Gnb2 Kcng1 Gnb1 Kcna7 Gnb3 Kcng3 Kcnc4 Kcnc3 Kcnh4 Kcnmb2 Kcnh5 Kcnab3 Gng8 Kcnh3 Kcnab1 Kcnma1 Gng3 Kcnb2 Kcnmb4 Gng2 Kcnq4 Kcnmb1 Kcns2 Kcnh2 Kcnj10 Kcnj3 Kcnq1 Kcna1 Kcnq3 Kcna3 Kcnj16 Kcna2 Kcnj15 Kcna4 Kcnh1 Kcna5 Kcnc1 Kcnq2 Kcnd3 Kcnd2 Kcnd1 Kcnj6 Kcnk1 Kcnj11 Kcnj2 Abcc8 Kcnj12 Kcnk9 Kcnj4 Kcnk7 Kcnk6 Kcnk2 Kcnk13 Kcnk3 Kcnk10 Kcnk4 Kcnk18 Kcnk16 Kcnj14 INTERLEUKIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 59%446652 Interleukin-1 signaling Map2k1 Chuk Il1rn Btrc Ubc Nfkb1 Fbxw11 Skp1a Il1r2 Il1r1 Tnip2 Myd88 Nod2 Nod1 Cul1 Il1b Il1a Map3k7 Peli1 Irak3 Irak2 Irak1 Tab1 Map2k6 Tab2 Traf6 Tollip Tab3 Map3k3 Ikbkb Ube2v1 Ripk2 Ube2n Sqstm1 Map2k4 Map3k8 Ikbkg Peli3 Irak4 Peli2 MRNA DECAY BY 3' TO 5' EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 59%429958 mRNA decay by 3' to 5' exoribonuclease Hbs1l Exosc9 Exosc8 Exosc7 Dcps Exosc5 Exosc4 Nt5c3b Skiv2l Ttc37 Wdr61 Dis3 Exosc3 Exosc1 Exosc2 REGULATION OF TLR BY ENDOGENOUS LIGAND%REACTOME DATABASE ID RELEASE 59%5686938 Regulation of TLR by endogenous ligand Fgg S100a1 Tlr4 Lbp Tlr2 S100a9 S100a8 Tlr6 Ly96 Cd14 Cd36 Tlr1 Fga Fgb Apob RESOLUTION OF SISTER CHROMATID COHESION%REACTOME%R-HSA-2500257.1 Resolution of Sister Chromatid Cohesion Pafah1b1 Zw10 Ska1 Nup85 Pmf1 Nup160 Spc25 Nudc Ppp2r1a Rps27 Spc24 Xpo1 Clasp2 Itgb3bp Nuf2 B9d2 Ppp2r5e Cdk1 Ppp2r5c Ppp2r5d Ppp2r5a Cenpf Ppp1cc Cenpq Cenpp Ccnb2 Ahctf1 Clasp1 Cenpm Cenpl Cenpo Clip1 Cenpn Ppp2r5b Aurkb Zwilch Cdca8 Cenpt Apitd1 Sec13 Stag2 Mapre1 Sgol2b Ercc6l Stag1 Dsn1 Nup107 Mad1l1 Smc1a Rad21 Cenph Cenpi Cenpe Cenpk Ppp2cb Kif2c Taok1 Birc5 Kif2b Kif18a Ckap5 Ppp2ca Bub1b Zwint Nup37 Incenp Wapal Nup43 Plk1 Nup133 Rcc2 Nsl1 Kif2a Ndel1 Spdl1 Ndc80 Kntc1 Bub3 Cdca5 Bub1 Cenpu Mad2l1 Casc5 Smc3 Cenpa Cenpc1 Ppp2r1b Cdc20 Sgol1 Pds5a Ranbp2 Mis12 Pds5b CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION%REACTOME DATABASE ID RELEASE 59%109688 Cleavage of Growing Transcript in the Termination Region Pabpn1 Srsf2 Thoc7 Thoc6 Srsf3 Zfp473 Slu7 Srsf11 Zc3h11a Magoh Cpsf1 Cstf1 Dhx38 Clp1 Thoc3 Srsf7 Thoc2 Thoc5 Thoc1 Srsf9 Ncbp1 Alyref Ncbp2 Srsf6 Nudt21 Cstf2t Fip1l1 Rbm8a Cstf3 Casc3 Sympk Eif4a3 U2af1l4 Chtop Srsf1 Cstf2 Cpsf3 Cpsf2 Cpsf4 Cpsf7 Lsm11 Ddx39b Upf3b Ddx39 Papola Fyttd1 Wdr33 Rnps1 Poldip3 Lsm10 Magohb Snrpb Snrpd3 Cdc40 Slbp Srrm1 TRANSPORT OF HA TRIMER, NA TETRAMER AND M2 TETRAMER FROM THE ENDOPLASMIC RETICULUM TO THE GOLGI APPARATUS%REACTOME DATABASE ID RELEASE 59%168874 Transport of HA trimer, NA tetramer and M2 tetramer from the endoplasmic reticulum to the Golgi Apparatus SYNTHESIS OF GDP-MANNOSE%REACTOME DATABASE ID RELEASE 59%446205 Synthesis of GDP-mannose Gmppa Gmppb Pmm2 Pmm1 Mpi TRANSLESION SYNTHESIS BY POLI%REACTOME DATABASE ID RELEASE 59%5656121 Translesion synthesis by POLI Poli Rev1 Pcna Rfc5 Mad2l2 Rpa2 Rpa1 Ubc Rfc3 Rpa3 Rfc2 Rfc4 Rfc1 Rev3l MITOCHONDRIAL TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 59%163316 Mitochondrial transcription termination Mterf1b GLYOXYLATE METABOLISM AND GLYCINE DEGRADATION%REACTOME%R-HSA-389661.4 Glyoxylate metabolism and glycine degradation Pdhb Dlat Gcsh Dbt Dhtkd1 Pdhx Pdha1 Gnmt Lipt2 Lipt1 Agxt Amt Gldc Hao1 Agxt2 Dld Ogdh Bckdha Bckdhb Lias Ndufab1 Grhpr Dlst Ddo Dao ENZYMATIC DEGRADATION OF DOPAMINE BY COMT%REACTOME%R-HSA-379397.2 Enzymatic degradation of dopamine by COMT Comt Maoa HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM%REACTOME%R-HSA-1638091.1 Heparan sulfate heparin (HS-GAG) metabolism Agrn Ndst2 Naglu Gusb B4galt7 Hpse Hs3st2 Bgn Dcn Bcan B3gat3 B3gat2 B3gat1 Hs3st5 Hpse2 Hs3st6 Hs3st4 Cspg4 Hs3st1 Cspg5 Hs6st1 Hs6st3 Hs6st2 Hs2st1 Glce Sgsh Ncan Xylt2 Vcan Xylt1 Sdc3 Sdc4 Gpc6 Ext2 Sdc2 Ext1 Gpc3 Sdc1 Gpc5 Gpc2 Glb1 Ndst3 Gpc4 Ndst1 Ndst4 Ids B3galt6 Idua Hs3st3a1 Slc35d2 Hs3st3b1 Hspg2 Gpc1 CLOSTRIDIUM NEUROTOXICITY%REACTOME%R-HSA-168799.1 Clostridium neurotoxicity Sv2c Vamp1 Sv2b Syt2 Syt1 Sv2a Vamp2 Stx1b Snap25 Stx1a REGULATED NECROSIS%REACTOME DATABASE ID RELEASE 59%5218859 Regulated Necrosis Fas Casp8 Fadd Ripk3 Tradd Birc3 Birc2 Fasl Ripk1 Tnfrsf10b Tnfsf10 Mlkl Xiap Traf2 HEDGEHOG 'ON' STATE%REACTOME%R-HSA-5632684.1 Hedgehog 'on' state Ulk3 Psmc6 Spopl Dzip1 Psmc5 Spop Psmc2 Psmd2 Psmb9 Psmf1 Psmb8 Psme4 Arrb2 Hhip Arrb1 Psmc1 Adrbk1 Psmc4 Psmc3 Psme3 Gas1 Gas8 Evc2 Boc Smo Evc Iqce Cdon Ptch1 Ihh Shh Dhh Rbx1 Csnk1a1 Cul3 Psmd12 Psma7 Psmd11 Kif3a Psmd14 Psma5 Psmb5 Psmb4 Ubc Psmd13 Itch Psmd10 Psma4 Psmb7 Psma3 Psma6 Psmb6 Psmb2 Psmb3 Psmb1 Psma2 Psma1 Gpr161 Cdc73 Sufu Psmd9 Gli3 Smurf1 Gli2 Gli1 Psmd1 Shfm1 Psme2 Psme1 Psmd3 Psmd4 Psmb10 Numb Psmd6 Psmd5 Psmd7 Smurf2 Psmb11 Psmd8 ACTIVATION OF BH3-ONLY PROTEINS%REACTOME%R-HSA-114452.2 Activation of BH3-only proteins Ppp3cc Trp53bp2 Ywhaz Ywhah Sfn Akt2 Akt3 Ppp1r13b Ywhag Ywhae Bad Dynll2 Trp73 E2f1 Tfdp2 Akt1 Tfdp1 Bid Ywhab Bcl2 Trp53 Mapk8 Trp63 Bmf Dynll1 Ppp3r1 Bcl2l11 COHESIN LOADING ONTO CHROMATIN%REACTOME DATABASE ID RELEASE 59%2470946 Cohesin Loading onto Chromatin Stag2 Stag1 Pds5a Pds5b Wapal Smc3 Smc1a Rad21 Nipbl Mau2 RETROGRADE TRANSPORT AT THE TRANS-GOLGI-NETWORK%REACTOME DATABASE ID RELEASE 59%6811440 Retrograde transport at the Trans-Golgi-Network Cog6 Golga4 Golga1 Cog3 Cog4 Scoc Naa38 Cog2 Vamp3 Naa30 Naa35 Cog1 Arfip2 Rabepk Tmf1 Rgp1 Nsf Arl1 M6pr Rab9 Stx16 Plin3 Igf2r Gcc1 Gcc2 Napb Napg Usp6nl Rab43 Napa Vamp4 Rhobtb3 Vti1a Stx6 Ric1 Vps54 Rab9b Arfrp1 Rab6b Rab6a Cog7 Vps52 Vps51 Cog8 Vps53 T(4;14) TRANSLOCATIONS OF FGFR3%REACTOME DATABASE ID RELEASE 59%2033515 t(4;14) translocations of FGFR3 Fgfr3 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE%REACTOME%R-HSA-168181.1 Toll Like Receptor 7 8 (TLR7 8) Cascade Irf7 Ppp2r1a Btrc Mapk9 Nfkb2 Nfkb1 Ecsit Fbxw11 Skp1a Saa3 Ppp2r5d Tlr8 Mapkapk3 Tlr7 Tnip2 Myd88 Nod2 Cul1 Nod1 Dhx9 Vrk3 S100b Elk1 Mef2c Mapk10 Mef2a Dusp3 Map3k7 Mapk7 Peli1 Creb1 Mapkapk2 Irak2 Irak1 App Map2k6 Tab1 Tab2 Jun Mapk8 Tab3 Map3k1 Ripk2 Map2k7 Dhx36 Ager Map2k3 Map2k4 Map3k8 Rela Atf2 Nfkbia Peli3 Nfkbib Irak4 Fos Peli2 Ppp2cb Map2k1 Chuk Tlr9 Ppp2ca Ubc Mapk3 Rps6ka5 Mapk1 Ppp2r1b Ticam2 Dusp7 Rps6ka3 Dusp6 Rps6ka2 Ticam1 Rps6ka1 Traf6 Ikbkb Ube2v1 Tlr4 Ube2n Tlr3 Ly96 Cd14 Ikbkg Mapk11 Mapk14 Dusp4 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING%REACTOME%R-HSA-879415.1 Advanced glycosylation endproduct receptor signaling Capza1 Capza2 App Saa3 Lgals3 Ager Prkcsh Ddost Mapk3 S100b Mapk1 ENTRY OF INFLUENZA VIRION INTO HOST CELL VIA ENDOCYTOSIS%REACTOME DATABASE ID RELEASE 59%168275 Entry of Influenza Virion into Host Cell via Endocytosis Cltc Clta RHO GTPASE EFFECTORS%REACTOME%R-HSA-195258.1 RHO GTPase Effectors Zw10 Dvl1 Ska1 Pik3c3 Nup85 Pmf1 Iqgap3 Nup160 Iqgap2 Ar Mkl1 Spc25 Dvl3 Actb Nudc Ppp2r1a Rps27 Pik3r4 Spc24 Ywhae Kdm4c Xpo1 Scai Kif14 Clasp2 Itgb3bp Dvl2 Nuf2 Wipf3 Wipf2 Pfn2 Pfn1 Wipf1 Srf Wasf2 Rhod Wasf3 Arpc5 Arpc4 H2afj Wasf1 Ctnna1 Cenpf H2afb2 Ppp1cc Diap1 Cenpq Diap3 Cenpp Ahctf1 Cybb Rac1 Cyba Cenpm Cenpl Cenpo Pak1 Clip1 Klc3 Cenpn Aurkb Klc2 Klc4 Zwilch Cdca8 Cenpt Apitd1 Sgol2b Kdm1a Ercc6l Rtkn Wasl Hist2h2be Was Dsn1 Nup107 Mad1l1 Hist2h2ac Cenph H3f3b Cenpi H3f3a Cenpe Cenpk Hist1h2bg Kif2c Taok1 Hist1h2bh Birc5 Srgap2 Kif2b Kif18a Actg1 Bub1b Zwint Nup37 Hist1h2bp Incenp Hist1h2bm Nup43 Ppp1r14a Nup133 Daam1 Rcc2 Hist1h2bj Nsl1 Hist1h2bb Kif2a Ndel1 Spdl1 Ndc80 Kntc1 Bub3 Nckap1l Bub1 Noxa1 Cenpu Mad2l1 Casc5 Cenpa Klc1 Abi1 Cenpc1 Abi2 Cttn Arpc1a Arpc1b Hist1h3d Nckap1 Sgol1 Hist1h2ak Noxo1 Ranbp2 Mis12 Hist1h2ag Ppp1r12b Cyfip1 Hist1h2ah Cyfip2 Rhpn2 Ncf4 Hist2h3c1 Ppp1r12a Ncf2 Rhpn1 Ncf1 Ptk2 Rhog Rhob Rock1 Rhoc Rock2 Ppp2cb Ppp2ca Nck1 Mapk3 Mapk1 Rhoa Sec13 Men1 Ctnnb1 Myl6 Myh11 Myh14 Myh10 Ppp2r1b Limk1 Ywhab Limk2 Cdc20 Pak3 Pak2 Myl12b Myl12a Rac2 Myh9 Pafah1b1 Itgb1 Ywhag B9d2 Ppp2r5e Dlg4 Ppp2r5c Ppp2r5d Ppp2r5a Clasp1 Ppp2r5b Mapre1 Cdkn1b Hist3h2ba Abl1 Nox3 Nox1 Cit Nf2 Ywhaz Cdh1 Ckap5 Cdc25c Ywhah Sfn Btk Plk1 Cftr Flna Gopc Ppp1cb Fmnl2 Fmnl3 H2afz Baiap2 H2afx Fmnl1 Brk1 Pkn2 Pkn1 Evl Pkn3 Iqgap1 Actr2 Actr3 Lin7b Hist2h2aa1 Kif5a Kif5b Mylk Nckipsd Ropn1 Pdpk1 Arpc3 Prc1 Ktn1 Arpc2 Rhoq Ncoa2 METABOLIC DISORDERS OF BIOLOGICAL OXIDATION ENZYMES%REACTOME DATABASE ID RELEASE 59%5579029 Metabolic disorders of biological oxidation enzymes Fdx1 Fdx1l Mc2r Pomc Cyp11a1 Fdxr DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC%REACTOME%R-HSA-3359474.1 Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC Mmachc GAP JUNCTION TRAFFICKING AND REGULATION%REACTOME DATABASE ID RELEASE 59%157858 Gap junction trafficking and regulation Ap2m1 Myo6 Gjd2 Tjp1 Dnm2 Dnm1 Dab2 Clta Gjd3 Gjb1 Gjd4 Gjb2 Cltc Gja1 Gjb4 Gjb3 Gja10 Gjc1 Gja8 Gja3 Gja5 Gjb6 Gjb5 Gja4 Gjc2 Cltb NFG AND PRONGF BINDS TO P75NTR%REACTOME DATABASE ID RELEASE 59%205017 NFG and proNGF binds to p75NTR Ngf Ngfr ION HOMEOSTASIS%REACTOME%R-HSA-5578775.1 Ion homeostasis Fxyd1 Abcc9 Fxyd4 Fxyd6 Camk2d Atp1a1 Slc8a2 Camk2a Slc8a1 Camk2b Fkbp1b Atp1b2 Atp1a2 Atp1a3 Slc8a3 Atp1b3 Atp1b1 Dmpk Camk2g Ryr3 Ryr1 Ryr2 Stim1 Trpc1 Atp2a1 Orai1 Orai2 Trdn Atp2a3 Atp2a2 Asph Kcnj11 Itpr1 Nos1 Atp2b3 Atp2b4 Atp2b1 Atp2b2 Ahcyl1 Prkaca Sri Fxyd7 Tnni3 Itpr3 Itpr2 RNA POLYMERASE II TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 59%75953 RNA Polymerase II Transcription Initiation Gtf2h5 Gtf2a1 Taf13 Gtf2h4 Taf11 Gtf2a2 Gtf2b Gtf2h3 Ercc3 Taf1 Taf2 Taf4b Taf7 Taf4a Taf12 Taf5 Taf6 Taf3 Ercc2 Polr2i Polr2f Polr2j Polr2e Gtf2e1 Polr2h Tbp Gtf2e2 Polr2c Mnat1 Polr2d Ak6 Polr2b Taf9b Taf9 Polr2k Polr2g Ccnh Cdk7 Polr2a Gtf2h1 Gtf2f1 Gtf2h2 Gtf2f2 RHO GTPASES ACTIVATE KTN1%REACTOME DATABASE ID RELEASE 59%5625970 RHO GTPases activate KTN1 Rac1 Kif5a Kif5b Rhoa Rhog Klc3 Ktn1 Klc2 Klc1 Klc4 PACKAGING OF EIGHT RNA SEGMENTS%REACTOME%R-HSA-168303.2 Packaging of Eight RNA Segments SYNTHESIS OF WYBUTOSINE AT G37 OF TRNA(PHE)%REACTOME%R-HSA-6782861.2 Synthesis of wybutosine at G37 of tRNA(Phe) Lcmt2 Tyw3 Tyw5 Trmt12 Tyw1 Trmt5 DEPURINATION%REACTOME DATABASE ID RELEASE 59%73927 Depurination Ogg1 Mpg Mutyh REGULATION OF COMPLEMENT CASCADE%REACTOME%R-HSA-977606.2 Regulation of Complement cascade C2 C6 C8b Cfi Cfb C9 C8a Pros1 C7 C8g Cfh C3 Cd46 Hc C5ar2 C3ar1 Vtn C5ar1 Cd59b MAP2K AND MAPK ACTIVATION%REACTOME DATABASE ID RELEASE 59%5674135 MAP2K and MAPK activation Lamtor2 Map2k1 Fgg Mark3 Itga2b Map2k2 Rap1a Nras Wdr83 Rap1b Araf Hras Raf1 Arrb2 Il17rd Arrb1 Cnksr1 Csk Cnksr2 Vcl Vwf Mapk3 Mapk1 Itgb3 Ksr1 Ywhab Iqgap1 Kras Pebp1 Fn1 Tln1 Braf Apbb1ip Fga Fgb REGULATION BY C-FLIP%REACTOME DATABASE ID RELEASE 59%3371378 Regulation by c-FLIP Fas Casp8 Fadd Tradd Fasl Ripk1 Tnfrsf10b Tnfsf10 Traf2 INHIBITION OF SIGNALING BY OVEREXPRESSED EGFR%REACTOME DATABASE ID RELEASE 59%5638303 Inhibition of Signaling by Overexpressed EGFR Egf Egfr LIGAND-DEPENDENT CASPASE ACTIVATION%REACTOME%R-HSA-140534.3 Ligand-dependent caspase activation Fas Ticam2 Casp8 Fadd Tradd Fasl Ripk1 Ticam1 Tnfrsf10b Tnfsf10 Tlr4 Tlr3 Ly96 Cd14 Traf2 G2 PHASE%REACTOME DATABASE ID RELEASE 59%68911 G2 Phase Cdk2 E2f1 Ccna1 Ccna2 E2f3 MRNA EDITING%REACTOME%R-HSA-75072.2 mRNA Editing Apobec3 A1cf Adarb1 Apobec2 Apobec1 Adar Apobec4 TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G2 CELL CYCLE ARREST%REACTOME%R-HSA-6804114.2 TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest Cdc25c Trp53 Sfn Pcna Carm1 Gadd45a Aurka Rbl2 Rbl1 Bax Cdk1 E2f4 Ep300 Prmt1 Tfdp2 Zfp385a Tfdp1 STRIATED MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 59%390522 Striated Muscle Contraction Tmod2 Tmod3 Tnnt2 Tnnt1 Actn2 Mybpc3 Tpm2 Tmod4 Des Tmod1 Tpm3 Neb Mybpc1 Myl2 Myl3 Mybpc2 Myl4 Ttn Tnni2 Tnni1 Tnnt3 Myh6 Myh8 Dmd Myh3 Myl1 Tcap Actn3 Tnnc2 Tnnc1 Tnni3 Vim SIGNALING BY LEPTIN%REACTOME%R-HSA-2586552.1 Signaling by Leptin Akap9 Ppp2r1a Csf2 Jak1 Stat3 Frs2 Nras Frs3 Rasgrf1 Psmf1 Raf1 Psme4 Il5ra Fgf1 Il17rd Fgf2 Cnksr1 Csk Cnksr2 Erbb2 Fgf9 Ptk2 Fgf7 Psme3 Fgf6 Fgf4 Fgf3 Ppp5c Ranbp9 Ppp2cb Shc1 Lamtor2 Nrg2 Ppp2ca Shc3 Nrg1 Shc2 Psma7 Artn Nrtn Brap Psmb5 Psmb4 Ubc Nrg3 Psmb7 Nrg4 Psmb6 Psmb2 Psmb3 Psmb1 Mapk3 Mapk1 Ksr1 Ptpra Dusp16 Dusp10 Map3k11 Paqr3 Psme2 Psme1 Ncam1 Sos1 Braf Psmb10 Apbb1ip Psmb11 Csf2rb2 Rapgef2 Csf2ra Actn2 Nf1 Pdgfrb Stat5b Pdgfra Stat5a Kbtbd7 Il2rg Arrb2 Egfr Arrb1 Ret Vwf Sptan1 Pspn Map2k1 Rbx1 Fgg Map2k2 Cul3 Psmd12 Pdgfb Psmd11 Rasgef1a Psmd14 Rasa3 Rasa4 Psmd13 Psmd10 Il2 Rasa2 Rasa1 Nefl Spred3 Kit Spred2 Grin2a Spred1 Spta1 Il5 Ppp2r1b Sptbn4 Ywhab Kras Gdnf Shfm1 Irs2 Syngap1 Hbegf Irs1 Il3ra Btc Il2ra Il2rb Angpt1 Ptpn11 Psmc6 Egf Fgf23 Psmc5 Fgf22 Mark3 Psmc2 Fgf20 Psmd2 Dab2ip Tek Psmb9 Psmb8 Araf Hras Grin1 Ppp2r5e Dlg4 Ppp2r5c Ppp2r5d Ppp2r5a Psmc1 Psmc4 Psmc3 Sptbn2 Itgb3 Sptbn1 Fyn Phb Grin2c Rasgrp4 Rasgrp3 Pebp1 Ppp2r5b Rasgrp1 Tln1 Fga Fgb Grin2d Lep Grin2b Sptb Hgf Gfra2 Gfra3 Gfra4 Ereg Jak2 Pea15a Itga2b Rap1a Jak3 Wdr83 Camk2d Rap1b Camk2a Fgfr4 Camk2b Psma5 Rasal3 Rasal2 Socs3 Psma4 Psma3 Psma6 Vcl Camk2g Psma2 Psma1 Gfra1 Psmd9 Dusp7 Iqgap1 Fgf16 Dusp6 Dusp9 Fgf15 Dusp8 Klb Fgf18 Psmd1 Met Fn1 Rasal1 Dusp1 Psmd3 Psmd4 Psmd6 Psmd5 Dusp2 Psmd7 Dusp5 Psmd8 Fgf10 Dusp4 DEFECTIVE CFTR CAUSES CYSTIC FIBROSIS%REACTOME%R-HSA-5678895.2 Defective CFTR causes cystic fibrosis Psmc6 Psmc5 Psmc2 Vcp Os9 Psmd2 Rnf185 Derl2 Rnf5 Psmb9 Psmb8 Psmf1 Psme4 Sel1l Psmc1 Psmc4 Psmc3 Psme3 Psmd12 Psma7 Psmd11 Cftr Erlin2 Psmd14 Psma5 Psmb5 Psmb4 Psmd13 Ubc Psmd10 Psma4 Psmb7 Psma3 Psma6 Psmb6 Psmb2 Psmb3 Psmb1 Psma2 Psma1 Psmd9 Erlin1 Psmd1 Shfm1 Psme2 Psme1 Derl1 Derl3 Psmd3 Psmd4 Psmb10 Psmd6 Psmd5 Psmd7 Psmb11 Psmd8 Erlec1 LOSS OF FUNCTION OF TGFBR1 IN CANCER%REACTOME%R-HSA-3656534.1 Loss of Function of TGFBR1 in Cancer Tgfbr1 Tgfb1 Fkbp1a Tgfbr2 Smad2 Smad3 TRANSPORT OF NUCLEOSIDES AND FREE PURINE AND PYRIMIDINE BASES ACROSS THE PLASMA MEMBRANE%REACTOME%R-HSA-83936.1 Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane Slc29a1 Slc28a2 Slc29a4 Slc29a2 Slc29a3 Slc28a3 Slc28a1 GPCR LIGAND BINDING%REACTOME%R-HSA-500792.2 GPCR ligand binding Ucn Gpr31b Fzd6 Wnt3a Ucn3 Fzd9 Crhbp Fzd2 Fzd10 Fzd1 Fzd3 Adgre1 Fzd4 Fzd5 Fzd7 Ptch2 Fzd8 F2rl3 F2rl2 Gal Gpr4 Oxt Htr5a Npy1r Kiss1r Rho F2rl1 Grpr Ptgdr Rgr Adm2 Mc5r Ptgfr Ntsr1 Ntsr2 Sucnr1 Ghsr Uts2b Npy5r Uts2r Taar8b Npy4r Taar1 Taar2 Taar5 Taar6 Pnoc Taar9 Npy2r Casr Adora2b Ptgdr2 Adora2a Trh Adora3 Opn1sw Adora1 Mc2r Fshr Adrb2 Fshb C5ar1 F2r Adrb1 Edn1 F2 Adrb3 Edn3 Edn2 Gpha2 Mc1r Ptgir Lpar5 Oxgr1 P2ry13 P2ry12 P2ry14 P2ry10 Ramp1 Brs3 Ccr9 Ccr8 Ccr7 Ccr6 Ccr4 Ccr3 Mc3r Calcrl Lpar6 Mc4r Ccr10 Ramp2 Ramp3 Cx3cl1 Ackr4 Ccl2 Ccl1 Cx3cr1 Ccrl2 Pth2r Tas2r118 Tas2r126 Tas2r121 Tas2r120 Npff Tas2r119 Iapp Gper1 Pth1r Tas2r108 Smo Ccl25 Ccl28 Galr2 Htr2a Agtr2 Htr2b Tas2r107 Htr2c Ptch1 Rrh Ihh Shh Agtr1a Dhh Htr1d Pmch Gpr143 Htr1f Gpr18 Qrfp Hcrtr1 Hcrtr2 Htr7 Galr1 Htr6 Fpr3 Htr4 Pomc Gpr17 Fpr2 Htr1b Htr1a P2ry1 P2ry2 C3ar1 Gpr55 Avp Avpr1a Avpr2 Npffr1 Avpr1b Cck Npffr2 P2ry6 P2ry4 Gngt1 Grp Gng7 Adcyap1r1 Gng4 Tbxa2r Adcyap1 Gcg Crhr1 Gngt2 Tas2r137 Glp1r Tas2r136 Tas2r135 Sst Nmb Gng10 Ackr3 Gcgr Tas2r131 Tas2r130 Tas2r138 Tas2r139 Nmu Chrm3 Chrm2 Chrm1 Trhr Nms Gprc6a Kiss1 Chrm5 Crh Chrm4 Tas2r140 Calcr Tas2r144 Xcr1 S1pr5 S1pr2 S1pr3 S1pr1 S1pr4 Sstr2 Sstr1 Opn3 Gng11 Opn4 Gng13 Sstr5 Gng12 Npbwr1 Gnb2 Sstr3 Gnb1 Sstr4 Gnb3 Ppy Gnb5 Cort Ghrhr Opn5 Gnb4 Npb Ghrh Lhcgr Ffar4 Glp2r Npy Gng8 Npw Sct Nmbr Gip Gng3 Gng2 Nps Gipr Psap C3 Lpar3 Lpar4 Lpar1 Lpar2 Gcat Ltb4r2 Oprd1 Ltb4r1 Pdyn Cxcl16 Cxcl13 Pthlh Cxcl12 Cxcl11 Gpr68 Gpr65 Cnr2 Cnr1 Ffar3 C5ar2 Nts Oprk1 Rxfp1 Rxfp2 Gpbar1 Rxfp4 Rxfp3 Ptger3 Ptger4 Saa3 Cxcl2 Ptger1 Ptger2 Cxcl9 Cxcl5 Wnt11 Wnt10a Grm7 Wnt3 Grm8 Wnt10b Grm2 App Wnt6 Grm3 Wnt4 Grm4 Wnt9b Hc Wnt9a Wnt7a Wnt2b Wnt7b Wnt16 Gpr132 Prok1 Mchr1 Prok2 Hebp1 Wnt8a Wnt8b Ffar2 Wnt5a Wnt1 Ffar1 Wnt2 Ccl5 Cxcr1 Fpr1 Ccr1 Prokr1 Agt Oprl1 Prokr2 Anxa1 Ptafr Cxcr2 Cxcr3 Nmur1 Nmur2 Cxcl3 Cckar Cxcl1 Pth Ccl20 Calca Ccr2 Cxcr6 Ccr5 Cxcl10 Cxcr4 Cxcr5 Apln Pth2 Adm Hrh3 Pyy Hrh1 Hrh2 Hrh4 Hcar1 Cckbr Aplnr Hcar2 Oprm1 Pf4 Qrfpr Gabbr2 Gabbr1 Cysltr1 Adra1a Adra1b Penk Adra1d Mtnr1a Mtnr1b Uts2 Hcrt Npsr1 Adra2a Adra2c Grm1 Adra2b Grm5 Tacr2 Tacr3 Bdkrb1 Tacr1 Cysltr2 Bdkrb2 Kng2 Tshr Gnrh1 Ppbp Insl5 Tas1r3 Insl3 Tas1r2 Tas1r1 Ppan Tshb Oxtr Ednra Ednrb Rln3 Rln1 Xcl1 Drd4 Drd5 Drd2 Drd3 Drd1 Opn1mw Tac2 Tac1 Gnrhr Cga Lhb Prlhr Adgre5 Xk Gpr183 Ackr1 Gpr35 Ece2 Ece1 Gpr37l1 Lppr3 Lppr2 Kel Prlh Nln Lppr1 Lppr5 Lppr4 Gpr37 MITOCHONDRIAL TRANSLATION TERMINATION%REACTOME DATABASE ID RELEASE 59%5419276 Mitochondrial translation termination Mrps14 Mrps11 Mrps16 Mrpl41 Mrps9 Mrps15 Mrpl28 Mrps17 Mrpl35 Dap3 Gadd45gip1 Mrps10 Eral1 Mrps12 Mrpl40 Mrpl38 Mrps5 Mrpl39 Mrps2 Mrpl32 Mrpl33 Mrpl34 Mrpl36 Mrps6 Mrpl37 Mrps7 Mrps34 Mrpl20 Mrps31 Mrps30 Mrpl1 Mrpl16 Mrpl2 Mrpl17 Mrpl14 Mrpl3 Mrpl4 Mrpl12 Mrpl13 Mrpl10 Mrpl11 Mrpl9 Mrpl55 Mrpl57 Mrpl19 Mrpl18 Chchd1 Mrpl54 Mrpl30 Ptcd3 Mtrf1l Mrps18a Mrpl22 Mrpl21 Mrps18b Mrps18c Mrpl24 Mrpl51 Mrps23 Mrps22 Mrpl50 Mrps25 Mrpl53 Mrps24 Mrpl52 Mrps28 Aurkaip1 Mrps26 Mrps27 Gfm2 Mrps21 Mrrf Mrpl47 Mrpl48 Ict1 Mrpl46 Mrpl43 Mrpl44 Mrpl49 Mrps33 Mrps35 Mrpl45 AURKA ACTIVATION BY TPX2%REACTOME DATABASE ID RELEASE 59%8854518 AURKA Activation by TPX2 Pafah1b1 Ccp110 Nek2 Cep57 Akap9 Haus7 Haus8 Ppp2r1a Ywhag Ywhae Hsp90aa1 Ninl Ywhaq Cep152 Prkar2b Haus3 Haus4 Cdk1 Cetn2 Ofd1 Haus2 Cep63 Alms1 Haus5 Haus6 Haus1 Tubb4a Tubb4b Clasp1 Ssna1 Tubg1 Csnk1d Cep250 Tuba4a Dynll1 Csnk1e Cep135 Aurka Cdk5rap2 Mapre1 Pcnt Sfi1 Cep70 Nedd1 Actr1a Cep131 Pcm1 Prkaca Hmmr Dync1i2 Fgfr1op Cep76 Cep78 Cep72 Dctn2 Dctn3 Ckap5 Cep164 Tubb5 Tpx2 Tuba1a Cep41 Plk1 Cenpj Dync1h1 Plk4 Sdccag8 BETA OXIDATION OF PALMITOYL-COA TO MYRISTOYL-COA%REACTOME%R-HSA-77305.2 Beta oxidation of palmitoyl-CoA to myristoyl-CoA Hadhb Hadha Acadvl ACTIVATION OF HOX GENES DURING DIFFERENTIATION%REACTOME%R-HSA-5619507.1 Activation of HOX genes during differentiation Rara Egr2 Paxip1 Suz12 Kmt2c Rarb Hoxa4 Hoxa1 Hoxa3 Ctcf Hoxd1 Cnot6 Hoxd4 Hoxd3 Pias2 Kdm6a Hoxc4 Zfp335 Hoxb4 Hoxb3 Hoxb2 Hoxb1 Kmt2d Hist2h3c1 Rbbp4 Mafb Hoxa2 Yy1 Pknox1 H2afj Meis1 Polr2i H2afb2 Polr2f Polr2e Polr2j Polr2h Polr2c Polr2d Ncor1 Jun Polr2b Polr2g Polr2k Pbx1 Crebbp Hist2h2be Hist3h2ba Rqcd1 Ep300 Polr2a Hist2h2ac Ajuba H3f3b Ncoa3 H3f3a Pax6 Hist1h2bg Hist1h2bh Eed Hist1h2bp Hist1h2bm Hist1h2bj Ezh2 Rbbp7 Hist1h2bb H2afz Rarg H2afx Hist2h2aa1 Rxra Hist1h3d Pcgf2 Hist1h2ak Ash2l Wdr5 Hist1h2ag Rbbp5 Ncoa6 Hist1h2ah Hdac3 DISEASES OF METABOLISM%REACTOME DATABASE ID RELEASE 59%5668914 Diseases of metabolism Mccc2 Mccc1 Ppp1r3c Ubc Pcca Acaca Pomc Pccb Epm2a Fdx1 Fdx1l Ccdc59 Pcx Gys2 Sftpb Sftpc Cyp11a1 Mmachc Sftpd Sftpa1 Gif Fdxr Amn Mut Mtrr Cd320 Idh1 Cubn Mmadhc Mc2r Mmaa Tcn2 Gys1 Gyg Ttf1 Mtr Csf2rb2 Csf2ra SLC-MEDIATED TRANSMEMBRANE TRANSPORT%REACTOME%R-HSA-425407.1 SLC-mediated transmembrane transport Slc22a6 Slc26a11 Nup85 Slc1a3 Slc33a1 Nup160 Slc1a2 Slc12a4 Slc1a7 Slc1a6 Slco4c1 Slc39a1 Slc12a5 Slc38a2 Slc1a1 Slc22a3 Slc22a4 Slc22a5 Slc39a5 Slc12a1 Slc39a4 Slc12a2 Slc32a1 Slc12a3 Slc39a3 Slc39a2 Slc12a6 Slc12a7 Slc39a8 Slc39a6 Slc39a7 Slc43a1 Slc25a22 Slc3a1 Slc43a2 Slc25a26 Slc28a3 Slc50a1 Slc28a1 Slc22a8 Slc22a7 Slc25a18 G6pc Slc29a1 Slc2a13 Slc28a2 Slc29a4 Slc29a2 Nup107 Slc29a3 Slc6a12 Ctns Slc6a7 Slc6a11 Slc41a2 Slc41a1 Slc1a5 Slc1a4 Slc40a1 Nup37 Nup43 Nup133 Slc22a2 Rhag Slc22a1 Slc44a3 Slc44a4 Slc44a5 Slc3a2 Slc35d1 Rhcg Slc6a9 Slc5a7 Slc44a1 Slc6a5 Slc44a2 Slc6a6 Slc14a2 Slc18a1 Slc6a20a Slc14a1 Slc6a18 Slc6a19 Slc6a1 Slc6a2 Slc6a13 Slc7a5 Slc6a15 Slc6a14 Rhbg Ranbp2 Gck Slc16a2 Slc38a1 Slc30a1 Slc34a1 Nup50 Slco2b1 Slc34a3 Slc20a1 Tpr Slc20a2 Slc39a10 Slc30a2 Slc30a3 Ndc1 Slc2a6 Nup214 Slc2a5 Aaas Nup210 Nup188 Nup54 Nup35 Slc34a2 Nupl2 Slc2a12 Nup62 Slc8b1 Slc2a4 Slc38a5 Nup205 Slc2a3 Slc38a4 Nup155 Slc2a10 Slc38a3 Nup88 Slc2a2 Pom121 Slc37a4 Slc2a1 Slc2a8 Rae1 Slc2a7 Slc7a6 Slco4a1 Slc7a1 Slc7a3 Slc13a3 Nup93 Emb Slc7a9 Slc13a1 Slc7a8 Slc13a2 Slc7a7 Nup153 Slc30a5 Slc22a12 Slc30a8 Slc13a5 Slc22a16 Slc30a6 Slc22a15 Slc30a7 Slc16a3 Slc4a7 Slc16a1 Slc4a9 Bsg Slc22a18 Slc13a4 Slc4a8 Slc16a8 Slc10a6 Slc11a2 Slc16a7 Slc47a1 Slc4a3 Slc7a10 Heph Slc4a4 Slc4a2 Slc4a5 Slc7a11 Slc8a2 Slc8a1 Slc24a4 Slc24a3 Slc24a2 Slc24a1 Slc8a3 Slco1c1 Slc15a3 Slc4a10 Slco1a4 Slc5a12 Slc5a11 Slco1b2 Slc45a3 Ahcyl2 Slc5a10 Slc17a1 Fgf21 Slc5a5 Slc2a9 Slc15a2 Slc15a1 Slc24a5 Slc17a6 Slc17a8 Slc31a1 Slc15a4 Slc26a3 Slc26a4 Sri Slc18a2 Slc26a9 Slc26a7 Slc39a14 Cp G6pc2 Slco2a1 G6pc3 Pdzd11 Slc4a1 Slc17a5 Slc5a8 Slc5a6 Avp Slc36a1 Slc36a2 Slc6a3 Hk1 Slc25a10 Hk2 Hk3 Apod Lcn9 Slc27a1 Slc27a6 Lcn12 Slc27a4 Slc35b2 Slc26a1 Slc26a2 Slc35b3 Alb Slc5a2 Slc5a3 Slc5a1 2010001E11Rik Slc5a9 Slc5a4a Slc9a1 Slc9a6 Slc9a5 Slc9a4 Slc9a3 Slc9a2 Slc9a9 Slc9a8 Slc9a7 Slc35b4 Slc35a1 Gckr Slc35a3 Slc11a1 Slc35c1 Slc35a2 Slc35d2 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY%REACTOME DATABASE ID RELEASE 59%442380 Zinc influx into cells by the SLC39 gene family Slc39a5 Slc39a14 Slc39a4 Slc39a3 Slc39a2 Slc39a1 Slc39a10 Slc39a8 Slc39a6 Slc39a7 SYNTHESIS OF EPOXY (EET) AND DIHYDROXYEICOSATRIENOIC ACIDS (DHET)%REACTOME%R-HSA-2142670.1 Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) Cyp2j6 Cyp2c65 Cyp1a1 Cyp1a2 Ephx2 Cyp2c50 Cyp1b1 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER%REACTOME%R-HSA-3645790.1 TGFBR2 Kinase Domain Mutants in Cancer Tgfbr1 Tgfb1 Fkbp1a Tgfbr2 RETINOID METABOLISM AND TRANSPORT%REACTOME DATABASE ID RELEASE 59%975634 Retinoid metabolism and transport Clps Agrn Akr1c6 Ldlr Lrat Lrp1 Apoc2 Apoc3 Gpihbp1 Bco1 Bco2 Ttr Lpl Akr1c18 Apoa4 Akr1c21 Apoa2 Apom Apoe Rdh11 Sdc3 Rbp2 Sdc4 Gpc6 Rbp1 Sdc2 Gpc3 Pnlip Sdc1 Gpc5 Akr1b10 Gpc2 Rbp4 Gpc4 Lrp2 Plb1 Lrp12 Apoa1 Hspg2 Apob Lrp10 Gpc1 BUTYROPHILIN (BTN) FAMILY INTERACTIONS%REACTOME DATABASE ID RELEASE 59%8851680 Butyrophilin (BTN) family interactions Btnl9 Btnl2 Btn1a1 Btn2a2 Xdh Ppl Cd209a ORC1 REMOVAL FROM CHROMATIN%REACTOME DATABASE ID RELEASE 59%68949 Orc1 removal from chromatin Psmc6 Psmc5 Psmc2 Psmd2 Psmb9 Psmf1 Psmb8 Rb1 Psme4 Mcm6 Cdc6 Cdk2 Mcm3 Mcm2 Mcm5 Mcm4 Psmc1 Ccna1 Psmc4 Psmc3 Ccna2 Psme3 Fzr1 Orc4 Orc5 Mcm8 Mcm7 Cdt1 Orc2 Orc3 Orc6 Orc1 Cdkn1b Cdkn1a Psmd12 Psma7 Psmd11 Psmd14 Psma5 Psmb5 Psmb4 Ubc Psmd13 Psmd10 Psma4 Psmb7 Psma3 Psma6 Psmb6 Psmb2 Psmb3 Psmb1 Psma2 Psma1 Psmd9 Psmd1 Shfm1 Psme2 Psme1 Psmd3 Psmd4 Psmb10 Psmd6 Psmd5 Psmd7 Psmb11 Psmd8 CELLULAR RESPONSES TO STRESS%REACTOME DATABASE ID RELEASE 59%2262752 Cellular responses to stress Pik3c3 Nup85 Vcp Prkaa2 Nup160 Pik3r4 Ywhae Mapk9 Nfkb1 Cat Gpx1 Mapkapk3 Rnf2 Prkaa1 Mapk10 Hif1a H2afj H2afb2 Dnajb1 Hsf1 Hsbp1 Nbn Cybb Cyba Mapk8 Jun Map2k7 Map2k3 Map2k4 Rela Il6 Rpa2 Rpa1 Atm Hist2h2be Nup107 Ep300 Rpa3 Hspa1a Hspa2 Hdac6 Hist2h2ac Fkbp4 Cryab H3f3b H3f3a Hspa1l Hspb8 Txnrd1 Gpx7 Hist1h2bg Tinf2 Gpx8 Hist1h2bh Pot1a Gpx3 Gpx5 Txn2 Sod3 Atg7 Terf1 Nox4 Atg5 Nup37 Terf2 Hspa8 Prdx3 Hist1h2bp Hist1h2bm Acd Nup43 Nup133 Hist1h2bj Tsc1 Txnrd2 Gpx6 Hist1h2bb Ccs Rbbp7 Nudt2 Stat3 Cul2 Vegfa Terf2ip Il1a Rps6ka3 Phc3 Rps6ka2 Rps6ka1 Hist1h3d Ulk1 Phc2 Phc1 Hist1h2ak Ranbp2 Hist1h2ag Vhl P4hb Hist1h2ah Prkag2 Prkag1 Prkag3 Nup50 Tpr Psmf1 Psme4 Ndc1 Ncf4 Nup214 Hist2h3c1 Sod2 Aaas Nup210 Cdk2 Ncf2 Nup188 Nup54 Ncf1 E2f1 Nup35 Rad50 Ccna1 Nupl2 Dnajb6 Nup62 Rbbp4 l7Rn6 Hspa4 Nup205 Hspa9 Ccna2 Nup155 Psme3 Nup88 Cdk4 Tfdp2 Pom121 Rps19bp1 Tfdp1 Rae1 Bag5 Bag1 Mapk7 Dnajc7 Sirt1 E2f2 Dnajc2 Nup93 Hspa12a Hspa12b Bag2 Bag3 Nup153 Ccar2 E2f3 Hspa14 Hspa4l St13 Hspa13 Ero1l Car9 Aqp8 Lamtor1 Atg12 Ajuba Lamtor2 Txn1 Lamtor5 Eed Psma7 Bag4 Lamtor4 Psmb5 Psmb4 Ubc Psmb7 Psmb6 Psmb2 Cdkn2a Psmb3 Psmb1 Prkab1 Map1lc3a Mapk3 Cdkn2b Map1lc3b Mapk1 Cited2 Trp53 Prkab2 Tceb1 Psme2 Hist1h3h Psme1 Ehmt2 Psmb10 Hsph1 Psmb11 Ehmt1 Mov10 Suz12 Hmga2 Becn1 Tsc2 Lmnb1 Ep400 Hmga1 Cabin1 Hist1h1d H1f0 Mlst8 Ubn1 Rb1 Cdkn2c Ccne1 Mdm4 Mtor Ccne2 Cdk6 Mapkapk2 Rptor Map2k6 Epas1 Hif3a Wipi2 Rb1cc1 Atg101 Atg4b Mre11a Atg4c Atg4a Atg4d Gabarapl1 Epo Atg9a Atg9b Wdr45b Wtip Egln3 Hif1an Chmp7 Wdr45 Chmp6 Chmp3 Rbx1 Cdkn1a Limd1 Rragd Gabarapl2 Psmd12 Atg16l1 Rragb Uvrag Rragc Ambra1 Psmd11 Rraga Atg10 Ezh2 Atg13 Chmp2a Atg3 Chmp4c Egln2 Chmp4b Mtmr3 Psmd14 Gabarap Psmd13 Psmd10 Ifnb1 Cdc23 Ube2d1 Ago1 Cdc27 Tnrc6c Cdc16 Ube2c Kat5 Gsk3b Anapc16 Ube2e1 Tnrc6b Anapc7 Anapc4 Shfm1 Anapc5 Tnrc6a Anapc1 Ago4 Anapc2 Ago3 Hira Cbx4 Hist1h1c Cbx8 Mdm2 Cbx2 Asf1a Hist1h1e Hist1h1b Bmi1 Hsp90ab1 Hist1h1a Psmc6 Psmc5 Psmc2 Prdx2 Psmd2 Prdx1 Psmb9 Hsp90aa1 Mapkapk5 Psmb8 Sp1 Arnt Dynll2 Psmc1 Psmc4 Psmc3 Anapc15 Anapc11 Anapc10 Fzr1 Ring1 Dynll1 Crebbp Gpx2 Hist3h2ba Cdkn1b Fos Prdx6 Mtmr14 Tnik Map3k5 Atox1 Mink1 Erf Map4k4 Id1 Cebpb Wipi1 Cbx6 Camk2d Kdm6b Hspa5 Camk2a Camk2b Psma5 Ube2d3 Atp7a Psma4 Psma3 Psma6 Akt1s1 H2afz Igfbp7 Camk2g Psma2 H2afx Ets2 Psma1 Ets1 Psmd9 Hist2h2aa1 Psmd1 Mapk11 Psmd3 Psmd4 Mapk14 Psmd6 Psmd5 Psmd7 Psmd8 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION%REACTOME DATABASE ID RELEASE 59%888590 GABA synthesis, release, reuptake and degradation Slc6a11 Hspa8 Dnajc5 Abat Snap25 Slc6a1 Gad1 Aldh5a1 Slc6a13 Gad2 Slc32a1 Rab3a Slc6a12 Syt1 Vamp2 Cplx1 Stx1a PI5P, PP2A AND IER3 REGULATE PI3K AKT SIGNALING%REACTOME%R-HSA-6811558.2 PI5P, PP2A and IER3 Regulate PI3K AKT Signaling Egf Fgf23 Fgf22 Fgf20 Frs2 Pdgfrb Ppp2r1a Pdgfra Vav1 Ppp2r5e Fgf1 Egfr Gab1 Ppp2r5c Fgf2 Ppp2r5d Ppp2r5a Erbb2 Fgf9 Pik3cb Fgf7 Pik3cd Fgf6 Fgf4 Fgf3 Fyn Ins2 Ppp2r5b Ier3 Pik3ca Hgf Cd86 Ppp2cb Pip5k1a Nrg2 Ereg Ppp2ca Nrg1 Pdgfb Cd80 Fgfr4 Nrg3 Nrg4 Kit Mapk3 Akt1 Pip5k1b Mapk1 Cd19 Pip5k1c Ppp2r1b Fgf16 Pip4k2b Pip4k2a Fgf15 Insr Pip4k2c Klb Fgf18 Pik3ap1 Met Trat1 Irs2 Lck Hbegf Irs1 Pik3r3 Btc Pik3r1 Ptpn11 Fgf10 Pik3r2 UNCOATING OF THE HIV VIRION%REACTOME DATABASE ID RELEASE 59%162585 Uncoating of the HIV Virion Ppia INITIAL TRIGGERING OF COMPLEMENT%REACTOME DATABASE ID RELEASE 59%166663 Initial triggering of complement C2 Cfb Crp Cfd Colec11 C3 Colec10 C1rb Mbl2 Gzmm C1s2 C1qc C1qb C1qa Fcnb EGFR TRANSACTIVATION BY GASTRIN%REACTOME DATABASE ID RELEASE 59%2179392 EGFR Transactivation by Gastrin Sos1 Egfr Hbegf Kras Mmp3 Nras Hras Prkca CA-DEPENDENT EVENTS%REACTOME%R-HSA-111996.1 Ca-dependent events Adcy7 Adcy6 Adcy5 Prkcd Adcy4 Adcy3 Adcy2 Prkar2a Prkcg Adcy1 Prkacb Adcy9 Adcy8 Prkca Prkar2b Adrbk1 Pla2g4a Mapk1 Creb1 Camk4 Pde1c Pde1b Pde1a Prkar1a Prkar1b Prkaca DAP12 SIGNALING%REACTOME%R-HSA-2424491.1 DAP12 signaling Akap9 Ppp2r1a Rac1 Csf2 Cd86 Jak1 Cd80 Vav2 Adcy7 Adcy6 Adcy5 Adcy4 Adcy3 Adcy2 Prkar2a Adcy1 Frs2 Nras Frs3 Rasgrf1 Adcy9 Psmf1 Adcy8 Raf1 Psme4 Il5ra Fgf1 Bad Il17rd Fgf2 Cnksr1 Csk Cnksr2 Erbb2 Fgf9 Ptk2 Fgf7 Psme3 Fgf6 Fgf4 Fgf3 Klrd1 Klrk1 Ppp5c Prkar1a Prkar1b Ranbp9 Ppp2cb Shc1 Lamtor2 Chuk Nrg2 Ppp2ca Shc3 Nrg1 Akt2 Akt3 Shc2 Psma7 Artn Nrtn Plcg1 Brap Psmb5 Psmb4 Ubc Nrg3 Psmb7 Nrg4 Psmb6 Psmb2 Psmb3 Psmb1 Mapk3 Akt1 Mapk1 Ksr1 Ptpra Dusp16 Dusp10 Map3k11 Pip4k2b Pip4k2a Trp53 Pip4k2c Paqr3 Pik3ap1 Pde1c Pde1b Psme2 Pde1a Psme1 Ncam1 Sos1 Rictor Braf Psmb10 Apbb1ip Ahcyl1 Psmb11 Csf2rb2 B2m Rapgef2 Grap2 Csf2ra Mov10 Lcp2 Casp9 Prkcd Prkce Actn2 Nf1 Prkcg Tsc2 Pdgfrb Pdgfra Mlst8 Kbtbd7 Prkca Vav1 Il2rg Arrb2 Egfr Gab1 Arrb1 Mtor Ret Phlpp1 Adrbk1 Vwf Phlpp2 Ins2 Sptan1 Pspn Map2k1 Rbx1 Fgg Cdkn1a Map2k2 Cul3 Psmd12 Pdgfb Psmd11 Rasgef1a Psmd14 Rasa3 Rasa4 Psmd13 Psmd10 Il2 Rasa2 Rasa1 Nefl Spred3 Kit Spred2 Grin2a Spta1 Spred1 Il5 Sptbn4 Ppp2r1b Ywhab Ago2 Ago1 Tnrc6c Kras Insr Trem2 Gsk3a Gsk3b Tnrc6b Gdnf Shfm1 Tnrc6a Ago4 Ago3 Itpr1 Trat1 Irs2 Mdm2 Lck Syngap1 Pten Hbegf Irs1 Il3ra Btc Il2ra Il2rb Itpr3 Ptpn11 Angpt1 Itpr2 Trib3 Psmc6 Egf Fgf23 Psmc5 Fgf22 Mark3 Psmc2 Fgf20 Psmd2 Dab2ip Prkacb Tek Psmb9 Psmb8 Araf Hras Grin1 Prkar2b Ppp2r5e Mapkap1 Dlg4 Ppp2r5c Rps6kb2 Ppp2r5d Ppp2r5a Psmc1 Psmc4 Psmc3 Pik3cb Foxo3 Sptbn2 Pik3cd Foxo1 Sptbn1 Itgb3 Fyn Creb1 Phb Grin2c Rasgrp4 Plcg2 Rasgrp3 Pebp1 Camk4 Ppp2r5b Syk Rasgrp1 Ier3 Tln1 Pik3ca Cdkn1b Fga Fgb Grin2d Prkaca Grin2b Nr4a1 Sptb Vav3 Prr5 Hgf Gfra2 Gfra3 Pip5k1a Gfra4 Ereg Jak2 Pea15a Itga2b Rap1a Jak3 Wdr83 Btk Camk2d Rap1b Camk2a Fgfr4 Camk2b Psma5 Rasal3 Tyrobp Rasal2 Psma4 Psma3 Psma6 Akt1s1 Vcl Camk2g Psma2 Psma1 Gfra1 Pip5k1b Cd19 Pip5k1c Psmd9 Dusp7 Iqgap1 Fgf16 Dusp6 Dusp9 Fgf15 Dusp8 Klb Fgf18 Them4 Psmd1 Met Fn1 Rasal1 Dusp1 Psmd3 Psmd4 Pdpk1 Psmd6 Psmd5 Dusp2 Pik3r3 Psmd7 Pik3r1 Dusp5 Psmd8 Fgf10 Pik3r2 Dusp4 LIPOPROTEIN METABOLISM%REACTOME DATABASE ID RELEASE 59%174824 Lipoprotein metabolism Npc1 Npc2 Hdlbp Sar1b Soat1 Soat2 Ldlr Prkacb Apoa4 Nr1h2 Apoa2 Reln Fyn Abca1 Lipa Apof Ces3b Abcg1 Zdhhc8 Lsr Sh3kbp1 Furin A2m Mylip Dab1 Nr1h3 Mbtps1 Prkaca Mbtps2 Pcsk9 Apobr Lcat Nceh1 Apoa1 Vldlr Apob Alb Ap2m1 Apoc2 Apoc3 Gpihbp1 Ap2a1 Lpl Ap2a2 Apoe Ap2s1 Fgf21 Apoa5 Lipc Pcsk6 Pcsk5 Clta Ap2b1 Amn Cltc Mttp Apoc1 Cubn Apoc4 P4hb Angptl3 Creb3l3 Angptl4 Ldlrap1 Gm6484 FGFR3B LIGAND BINDING AND ACTIVATION%REACTOME%R-HSA-190371.2 FGFR3b ligand binding and activation Fgf1 Fgf20 Fgf18 Fgf9 HDR THROUGH HOMOLOGOUS RECOMBINATION (HR) OR SINGLE STRAND ANNEALING (SSA)%REACTOME DATABASE ID RELEASE 59%5693567 HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA) Ppp4c Fam175a Pias4 Polh Pcna Clspn Rnf168 Trex1 Polk Rfc5 Ube2v2 Rfc3 Eme1 Cdk2 Brcc3 Rfc2 Trp53bp1 Rad50 Ccna1 Rad51b Uimc1 Rad51c Gen1 Ccna2 Rfc4 Tipin Babam1 Rfc1 Ppp4r2 Rnf4 Nbn Pole Atrip Dna2 Pold1 Pold2 Pold3 Bard1 Pold4 Pole2 Rpa2 Mre11a Rpa1 Atm Hist2h2be Hist3h2ba Rpa3 Abl1 Top3a Ube2i Ercc4 Rad17 Rtel1 Ercc1 Pole4 Brca2 Pole3 Hist1h2bg Hist1h2bh Chek1 Hist1h2bp Hist1h2bm Rbbp8 Topbp1 Hist1h2bj Hist1h2bb Rad9a Blm Ubc Rad1 Rad9b Hus1 Mdc1 H2afx Exo1 Brip1 Rad52 Herc2 Rad51 Timeless Spidr Bre Rad51ap1 Sirt6 Kat5 Slx4 Wrn Ube2n Mus81 Whsc1 Hist1h3h Palb2 Brca1 Xrcc3 Rad51d Xrcc2 INHIBITION OF IFN-BETA%REACTOME DATABASE ID RELEASE 59%168888 Inhibition of IFN-beta ARACHIDONATE PRODUCTION FROM DAG%REACTOME%R-HSA-426048.2 Arachidonate production from DAG Daglb Abhd12 Abhd6 Dagla Mgll REGULATION OF CYTOSKELETAL REMODELING AND CELL SPREADING BY IPP COMPLEX COMPONENTS%REACTOME DATABASE ID RELEASE 59%446388 Regulation of cytoskeletal remodeling and cell spreading by IPP complex components Rsu1 Pxn Tesk1 Arhgef6 Actn1 Parvb Parva NOTCH-HLH TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 59%350054 Notch-HLH transcription pathway Crebbp Maml1 Notch4 Notch1 Mamld1 Maml3 Rbpj Kat2b Notch3 Maml2 Kat2a Notch2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME DATABASE ID RELEASE 59%975163 IRAK2 mediated activation of TAK1 complex upon TLR7 8 or 9 stimulation Map3k7 Ticam2 Irak2 Ticam1 Tab1 Traf6 Tab2 Tab3 Tlr4 Tlr3 Ly96 Cd14 Ubc DEFECTIVE B4GALT7 CAUSES EDS, PROGEROID TYPE%REACTOME%R-HSA-3560783.1 Defective B4GALT7 causes EDS, progeroid type Agrn Sdc3 Sdc4 Gpc6 Bgn Sdc2 Dcn Gpc3 Sdc1 Gpc5 Bcan Gpc2 Gpc4 Cspg4 Cspg5 Ncan Vcan Hspg2 Gpc1 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL%REACTOME DATABASE ID RELEASE 59%198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Amica1 Itgb1 Oscar Slamf6 Slamf7 Crtam Cd300a Klrg1 Cd81 Cd8a Icam4 Fcgr2b Icam5 Treml4 Cd160 Ncr1 Treml2 Cd200 Treml1 Cd96 Trem1 Cd22 Mill2 Fcgr4 Cd300e Klrd1 Klrk1 Cd226 Fcgr1 Sell Sh2d1b1 Klrb1 Cd300lb Klrc1 Cd200r1 Icam2 H2-M3 H2-M5 Cd300lf Siglec1 Cdh1 Cd8b1 Cd300lg C3 H2-Q1 Itga4 Sh2d1a Siglecg Siglece Icam1 Tyrobp Itgb7 Itgb2 Itgal Lilra5 Cxadr Cd19 Cd40lg Hcst Pvrl2 Vcam1 AF251705 Trem2 Lair1 Cd3d Cd3e Cd1d2 H2-Q10 B2m Cd3g AXONAL GROWTH STIMULATION%REACTOME DATABASE ID RELEASE 59%209563 Axonal growth stimulation Ngf Arhgdia Rhoa Ngfr REGULATION OF GENE EXPRESSION IN ENDOCRINE-COMMITTED (NEUROG3+) PROGENITOR CELLS%REACTOME DATABASE ID RELEASE 59%210746 Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells Neurod1 Nkx2-2 Neurog3 Pax4 Insm1 DEGRADATION OF GLI2 BY THE PROTEASOME%REACTOME DATABASE ID RELEASE 59%5610783 Degradation of GLI2 by the proteasome Psmc6 Psmc5 Psmc2 Psmd2 Prkacb Psmb9 Psmb8 Psmf1 Psme4 Btrc Skp1a Psmc1 Psmc4 Psmc3 Cul1 Psme3 Prkaca Rbx1 Csnk1a1 Psmd12 Psma7 Psmd11 Psmd14 Psma5 Psmb5 Psmb4 Psmd13 Ubc Psmd10 Psma4 Psma3 Psmb7 Psma6 Psmb6 Psmb2 Psmb3 Psma2 Psmb1 Psma1 Sufu Psmd9 Gli2 Gsk3b Psmd1 Shfm1 Psme2 Psme1 Psmd3 Psmd4 Psmb10 Psmd6 Psmd5 Psmd7 Psmb11 Psmd8 METABOLISM OF INGESTED MESEO2H INTO MESEH%REACTOME%R-HSA-5263617.2 Metabolism of ingested MeSeO2H into MeSeH Txnrd1 PROTEIN UBIQUITINATION%REACTOME%R-HSA-8852135.1 Protein ubiquitination Prkdc Ube2b Ube2r2 Ube2q2 Usp9x Ube2a Uba6 Otulin Rtf1 Cdc34 Bcl10 Rnf144a Usp5 Usp7 Hist3h2ba Hist2h2be Uchl3 Wdr61 Hist1h2bg Hist1h2bh Paf1 Wac Ube2t Hist1h2bp Hist1h2bm Hist1h2bj Rraga Ube2e3 Hist1h2bb Ube2d3 Ubc Ctr9 Cdc73 Ube2d1 Ube2z Ube2w Ube2c Ube2g2 Ube2n Ube2k Ube2e1 Ube2g1 Ube2h Rnf181 Rnf20 Rnf40 Leo1 Ube2l3 Uba1 Rnf152 TRANSLATION INITIATION COMPLEX FORMATION%REACTOME DATABASE ID RELEASE 59%72649 Translation initiation complex formation Eif2s1 Eif2s2 Eif3i Eif3k Eif3l Eif3m Rps21 Rps27 Eif3a Eif3b Eif4b Eif3c Rps25 Eif3d Rps26 Rps27l Eif3e Eif3f Eif3h Eif3g Rps9 Eif2s3x Rps7 Rps5 Eif4a1 Eif4a2 Eif1ax Eif3j2 Rps15a Rps3 Rps16 Eif4e Rps14 Rps19 Rps18 Eif4h Pabpc1 Rps11 Eif4g1 Rps10 Rpsa Rps4x DEGRADATION OF DVL%REACTOME DATABASE ID RELEASE 59%4641258 Degradation of DVL Psmc6 Dvl1 Psmc5 Dact1 Psmc2 Dvl3 Psmd2 Psmb9 Psmb8 Psmf1 Dvl2 Psme4 Psmc1 Psmc4 Psmc3 Psme3 Hecw1 Klhl12 Rbx1 Cul3 Psmd12 Psma7 Psmd11 Psmd14 Psma5 Psmb5 Psmb4 Psmd13 Ubc Psmd10 Psma4 Psma3 Psmb7 Psma6 Psmb6 Psmb2 Psmb3 Psma2 Psmb1 Psma1 Psmd9 Psmd1 Shfm1 Psme2 Psme1 Psmd3 Psmd4 Psmb10 Psmd6 Psmd5 Psmd7 Psmb11 Psmd8 HH MUTANTS THAT DON'T UNDERGO AUTOCATALYTIC PROCESSING ARE DEGRADED BY ERAD%REACTOME%R-HSA-5362768.1 Hh mutants that don't undergo autocatalytic processing are degraded by ERAD Psmc6 Psmc5 Psmc2 Vcp Os9 Psmd2 Derl2 Psmb9 Psmb8 Psmf1 Psme4 Syvn1 Sel1l Psmc1 Psmc4 Psmc3 Psme3 Shh Psmd12 Psma7 Psmd11 Psmd14 Psma5 Psmb5 Psmb4 Psmd13 Ubc Psmd10 Psma4 Psma3 Psmb7 Psma6 Psmb6 Psmb2 Psmb3 Psma2 Psmb1 Psma1 Psmd9 Psmd1 Shfm1 Psme2 Psme1 Psmd3 Psmd4 Psmb10 Psmd6 Psmd5 Psmd7 Psmb11 Psmd8 Erlec1 FORMATION OF THE CORNIFIED ENVELOPE%REACTOME DATABASE ID RELEASE 59%6809371 Formation of the cornified envelope Perp Jup Pkp3 Pkp2 2010005H15Rik Tchh Lce3b Lor Pkp4 Klk13 Sprr2k Dsc2 Tgm5 Dsc3 Tgm1 Capn1 Kazn Cdsn Capns1 Lce1m Dsg1a Dsc1 Dsg3 Klk12 Dsp Dsg2 Casp14 Klk14 Rptn Pcsk6 Sprr1b Pkp1 Cela2a Furin St14 Klk8 Evpl Klk5 Dsg4 Spink5 Prss8 Ppl MITOTIC PROPHASE%REACTOME%R-HSA-68875.2 Mitotic Prophase Nup85 Nup160 Vrk1 Lmnb1 Nup50 Ppp2r1a Tpr Prkcb Rb1 Prkca Ndc1 Rab2a Nup214 Hist2h3c1 Arpp19 Aaas Cdk1 Mastl Nup210 Nup188 Ppp2r2d Golga2 Mcph1 Nup54 Nup35 Gorasp2 Nupl2 Nup62 Nup205 Ensa Nup155 Nup88 Nek6 Pom121 Nek7 H2afj Blzf1 Nek9 Rae1 H2afb2 Ccnb2 Nup93 Lpin2 Nup153 Rab1 Smc4 Ncaph2 Smc2 Ncapg2 Ncapd3 Hist2h2be Banf1 Hist3h2ba Nup107 Lpin3 Lpin1 Hist2h2ac H3f3b H3f3a Ppp2cb Hist1h2bg Hist1h2bh Ppp2ca Nup37 Hist1h2bp Gorasp1 Hist1h2bm Nup43 Plk1 Nup133 Hist1h2bj Hist1h2bb Emd Setd8 H2afz H2afx Lemd3 Mapk1 Ctdnep1 Lemd2 Cnep1r1 Ppp2r1b Hist2h2aa1 Hist1h3d Hist1h3h Rab1b Hist1h2ak Ranbp2 Hist1h2ag Uso1 Hist1h2ah ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION%REACTOME%R-HSA-2730905.1 Role of LAT2 NTAL LAB on calcium mobilization Casp9 Tsc2 Pdgfrb Pdgfra Ppp2r1a Mlst8 Vav1 Egfr Gab1 Mtor Phlpp1 Phlpp2 Ins2 Cd86 Cdkn1a Pdgfb Cd80 Lyn Kit Ppp2r1b Ago2 Ago1 Tnrc6c Insr Gsk3a Gsk3b Tnrc6b Tnrc6a Ago4 Ago3 Trat1 Irs2 Mdm2 Lck Pten Hbegf Irs1 Btc Ptpn11 Trib3 Egf Fgf23 Fgf22 Fgf20 Frs2 Ppp2r5e Mapkap1 Fgf1 Bad Ppp2r5c Rps6kb2 Fgf2 Ppp2r5d Ppp2r5a Erbb2 Fgf9 Pik3cb Fgf7 Foxo3 Pik3cd Fgf6 Foxo1 Fgf4 Fgf3 Fyn Creb1 Ppp2r5b Syk Ier3 Pik3ca Cdkn1b Nr4a1 Prr5 Hgf Ppp2cb Pip5k1a Chuk Ereg Nrg2 Ppp2ca Nrg1 Akt2 Akt3 Fgfr4 Gab2 Nrg3 Nrg4 Akt1s1 Mapk3 Pip5k1b Akt1 Mapk1 Cd19 Pip5k1c Fgf16 Pip4k2b Pip4k2a Fgf15 Trp53 Pip4k2c Klb Fgf18 Pik3ap1 Them4 Met Sos1 Rictor Pdpk1 Lat2 Pik3r3 Pik3r1 Fgf10 Pik3r2 Mov10 INFLUENZA LIFE CYCLE%REACTOME DATABASE ID RELEASE 59%168255 Influenza Life Cycle Rpl39 Rplp1 Nup85 Canx Nup160 Rpl7 Nup50 Rps21 Tpr Rplp2 Rps27 Xpo1 Hsp90aa1 Rps25 Rpl4 Ndc1 Rps26 Nup214 Rps27l Aaas Rpl18a Nup210 Nup188 Rpl34 Nup54 Rpl32 Nup35 Nupl2 Nup62 Nup205 Rpl26 Rpl24 Nup155 Nup88 Rps9 Pom121 Rps7 Rae1 Rps5 Polr2i Polr2f Polr2j Polr2e Polr2h Nup93 Polr2c Polr2d Polr2b Nup153 Polr2k Polr2g Nup107 Hspa1a Polr2a Ran Rpsa Gtf2f1 Rpl37 Rps4x Gtf2f2 Nup37 Calr Nup43 Nup133 Dnajc3 Rpl22 Rpl10l Rpl23 Rpl39l Rpl13a Rpl22l1 Rps15a Kpnb1 Rpl11 Rpl17 Clta Rps3 Rpl19 Rpl18 Kpna1 Rps16 Ipo5 Rps14 Grsf1 Rps19 Cltc Rps18 Ranbp2 Rps11 Rps10 PHASE 3 - RAPID REPOLARISATION%REACTOME%R-HSA-5576890.1 Phase 3 - rapid repolarisation Kcne4 Kcnh2 Kcne3 Kcne2 Kcne1 Akap9 Kcnq1 Kcne1l TRANSCRIPTIONAL ACTIVATION OF P53 RESPONSIVE GENES%REACTOME%R-HSA-69560.2 Transcriptional activation of p53 responsive genes Cdkn1a Trp53 Pcbp4 Zfp385a GSD XV%REACTOME DATABASE ID RELEASE 59%3814836 GSD XV Gys1 Gyg INFECTIOUS DISEASE%REACTOME DATABASE ID RELEASE 59%5663205 Infectious disease Xrcc5 Nup85 Xrcc6 Nup160 Cdk9 Rps27 Isg15 Xpo1 Btrc Taf1 Taf2 Taf4b Taf7 Taf4a Rngtt Taf5 Rnmt Taf6 Taf3 Rac1 Src Npm1 Map2k7 Map2k4 Taf9 Ccnt1 Psip1 Nedd4l Banf1 Nup107 Hspa1a Lig1 Fen1 Ccnt2 Txnrd1 Taf13 Taf11 Ap2m1 Nup37 Calr Nup43 Nup133 Ap2a1 Ap2a2 Sh3gl2 Ccr5 Taf12 Cxcr4 Ap2s1 Clta Ap2b1 Atp6v1h Ipo5 Grsf1 Cltc Ranbp2 Kpna3 Kpna4 Kpna7 Lig4 Nup50 Tpr Psmf1 Psme4 Ndc1 Nup214 Aaas Nup210 Skp1a Nup188 Nup54 Nup35 Nupl2 Nup62 Nup205 Nup155 Sv2a Psme3 Nup88 Pom121 Rae1 Nup93 Sv2c Vamp1 Nup153 Sv2b Furin Ssrp1 Syt2 Ran Gtf2h1 Gtf2h2 Gtf2h5 Gtf2h4 Cd8b1 Psma7 Cul5 Snap25 Gtf2h3 Psmb5 Psmb4 Ubc Psmb7 Psmb6 Psmb2 Psmb3 Psmb1 Ppia Tcea1 Tceb1 Kpnb1 Tceb3 Psme2 Supt16 Psme1 Kpna1 Ap1s2 Ap1b1 Ap1s1 Psmb10 Ap1g1 Pacs1 H2-Q10 Xrcc4 Ap1s3 Cdk7 Syt1 Vamp2 Psmb11 B2m Eif2ak2 Ap1m2 Stx1a Ap1m1 Gtf2a1 Gtf2a2 Gtf2b Hmga1 Elmo1 Stx1b Polr2i Polr2j Gtf2e1 Nelfa Nelfb Gtf2e2 Polr2c Mnat1 Polr2d Supt4a Eef2 Polr2b Slc25a4 Polr2g Ctdp1 Sh3gl1 Polr2a Nelfe Stam Supt5 Hgs Nelfcd Gtf2f1 Ncbp1 Ncbp2 Stam2 Gtf2f2 Eps15 Chmp5 Chmp7 Map2k1 Chmp6 Rbx1 Chmp3 Vps37d Rcc1 Cbll1 Ltf Pdzd3 Vps37c Vps37b Map2k2 Ctnnb1 Pdcd6ip Psmd12 Tonsl Vps4b Psmd11 Vps4a Vta1 Chmp2a Chmp4c Chmp4b Psmd14 Ercc3 Psmd13 Cbl Psmd10 Nmt2 Vps37a Ranbp1 Nmt1 Ercc2 Shfm1 Dock2 Pak2 Gucy2c Lck Tsg101 Cd4 Hbegf Hsp90ab1 Rpl39 Psmc6 Rplp1 Psmc5 Canx Psmc2 Rpl7 Psmd2 Rps21 Rplp2 Psmb9 Hsp90aa1 Psmb8 Rps25 Rpl4 Rps26 Rps27l Rpl18a Rpl34 Rpl32 Arf1 Psmc1 Psmc4 Rpl26 Psmc3 Rpl24 Rps9 Rps7 Rps5 Polr2f Fyn Hck Polr2e Pabpn1 Polr2h Tbp Ell Taf9b Sh3kbp1 Polr2k Slc25a5 Rpsa Rpl37 Rps4x Ctnnd1 Cdh1 Cpsf4 Psma5 Psma4 Psma3 Psma6 Psma2 Psma1 Cd9 Dnajc3 Psmd9 Rpl22 Rpl10l Rpl23 Tgfb1 Rpl39l Ak6 Rpl13a Rpl22l1 Rps15a Psmd1 Rpl11 Met Rpl17 Rps3 Rpl19 Rpl18 Rps16 Rps14 Psmd3 Rps19 Psmd4 Rps18 Ccnh Psmd6 Psmd5 Ccnk Rps11 Rps10 Psmd7 Psmd8 EXPORT OF VIRAL RIBONUCLEOPROTEINS FROM NUCLEUS%REACTOME%R-HSA-168274.2 Export of Viral Ribonucleoproteins from Nucleus Nup85 Nup160 Nup37 Nup50 Tpr Nup43 Nup133 Xpo1 Ndc1 Nup214 Aaas Nup210 Nup188 Nup54 Nup35 Nupl2 Nup62 Nup205 Nup155 Nup88 Pom121 Rae1 Nup93 Nup153 Ranbp2 Nup107 Hspa1a Ran FORMATION OF ANNULAR GAP JUNCTIONS%REACTOME%R-HSA-196025.2 Formation of annular gap junctions Gja1 Cltc Ap2m1 Dab2 Dnm2 Clta Dnm1 Cltb DEFECTIVE POMT2 CAUSES MDDGA2, MDDGB2 AND MDDGC2%REACTOME%R-HSA-5083629.1 Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2 Dag1 PARADOXICAL ACTIVATION OF RAF SIGNALING BY KINASE INACTIVE BRAF%REACTOME DATABASE ID RELEASE 59%6802955 Paradoxical activation of RAF signaling by kinase inactive BRAF Map2k1 Fgg Mark3 Jak2 Itga2b Map2k2 Rap1a Nras Rap1b Araf Brap Hras Raf1 Arrb2 Arrb1 Cnksr1 Csk Cnksr2 Vcl Vwf Mapk3 Mapk1 Itgb3 Ksr1 Ywhab Phb Iqgap1 Map3k11 Kras Pebp1 Fn1 Tln1 Braf Apbb1ip Fga Fgb INTERLEUKIN-17 SIGNALING%REACTOME%R-HSA-448424.1 Interleukin-17 signaling Il17rb Il17ra Il17re Il17rc Il17f Il17a Il17c Il25 ACTIVATION OF PKB%REACTOME%R-HSA-165158.2 Activation of PKB Pdpk1 Akt2 Them4 Trib3 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION%REACTOME%R-HSA-2032785.2 YAP1- and WWTR1 (TAZ)-stimulated gene expression Med1 Ppara Tbl1x Helz2 Yap1 Gata4 Tead3 Tead1 Tead2 Ctgf Chd9 Tbx5 Wwtr1 Hipk1 Hipk2 Rxra Tead4 Carm1 Crebbp Nppa Nkx2-5 Smarcd3 Ncoa1 Kat2b Ncoa6 Tbl1xr1 Ncoa2 Runx2 TRUNCATIONS OF AMER1 DESTABILIZE THE DESTRUCTION COMPLEX%REACTOME DATABASE ID RELEASE 59%5467348 Truncations of AMER1 destabilize the destruction complex Ppp2r1b Ppp2cb Apc Axin1 Ppp2ca Amer1 Csnk1a1 Gsk3b Ppp2r1a Ppp2r5b Ppp2r5e Ppp2r5c Ppp2r5d Ppp2r5a SUMOYLATION OF TRANSCRIPTION FACTORS%REACTOME%R-HSA-3232118.3 SUMOylation of transcription factors Tfap2b Sumo3 Tfap2c Trp53 Pias4 Pias3 Sp3 Mdm2 Pias1 Mitf Cdkn2a Trp53bp1 Mta1 Ube2i IGF1R SIGNALING CASCADE%REACTOME DATABASE ID RELEASE 59%2428924 IGF1R signaling cascade Pik3c3 Prkaa2 Akap9 Ppp2r1a Pik3r4 Prkaa1 Csf2 Jak1 Tsc1 Prkag2 Prkag1 Prkag3 Frs2 Nras Frs3 Rasgrf1 Psmf1 Raf1 Psme4 Il5ra Fgf1 Il17rd Fgf2 Cnksr1 Csk Cnksr2 Erbb2 Fgf9 Ptk2 Fgf7 Psme3 Fgf6 Fgf4 Fgf3 Ppp5c Ranbp9 Lamtor1 Ppp2cb Shc1 Lamtor2 Ppm1a Nrg2 Tlr9 Ppp2ca Igf1r Shc3 Lamtor5 Irs4 Nrg1 Igf2 Akt2 Igf1 Shc2 Psma7 Artn Nrtn Lamtor4 Brap Psmb5 Psmb4 Ubc Nrg3 Psmb7 Nrg4 Psmb6 Psmb2 Psmb3 Psmb1 Prkab1 Mapk3 Akt1 Mapk1 Ksr1 Ptpra Dusp16 Dusp10 Stk11 Map3k11 Prkab2 Paqr3 Psme2 Psme1 Ncam1 Sos1 Braf Psmb10 Apbb1ip Psmb11 Csf2rb2 Rapgef2 Csf2ra Actn2 Nf1 Tsc2 Pdgfrb Pdgfra Mlst8 Kbtbd7 Il2rg Arrb2 Egfr Gab1 Arrb1 Mtor Ret Vwf Rptor Sptan1 Pspn Pde3b Map2k1 Rbx1 Fgg Map2k2 Cul3 Rragd Psmd12 Rragb Pdgfb Rragc Psmd11 Rraga Rasgef1a Eif4b Psmd14 Rasa3 Rasa4 Psmd13 Psmd10 Il2 Rasa2 Rasa1 Nefl Spred3 Kit Spred2 Grin2a Spred1 Spta1 Il5 Sptbn4 Ppp2r1b Ywhab Kras Gdnf Shfm1 Cab39 Eif4e Strada Irs2 Stradb Cab39l Syngap1 Eef2k Hbegf Eif4g1 Irs1 Eif4ebp1 Il3ra Btc Il2ra Il2rb Angpt1 Ptpn11 Trib3 Psmc6 Egf Fgf23 Psmc5 Fgf22 Mark3 Psmc2 Fgf20 Psmd2 Dab2ip Tek Psmb9 Psmb8 Araf Hras Grin1 Ppp2r5e Dlg4 Ppp2r5c Ppp2r5d Ppp2r5a Psmc1 Psmc4 Psmc3 Pik3cb Sptbn2 Sptbn1 Itgb3 Fyn Phb Grin2c Rasgrp4 Rasgrp3 Pebp1 Ppp2r5b Rasgrp1 Tln1 Pik3ca Fga Fgb Grin2d Grin2b Sptb Hgf Gfra2 Gfra3 Gfra4 Ereg Jak2 Pea15a Itga2b Rap1a Jak3 Wdr83 Camk2d Rap1b Camk2a Fgfr4 Camk2b Psma5 Rasal3 Rasal2 Psma4 Psma3 Psma6 Akt1s1 Vcl Camk2g Psma2 Psma1 Gfra1 Psmd9 Dusp7 Iqgap1 Fgf16 Dusp6 Dusp9 Fgf15 Dusp8 Klb Fgf18 Them4 Psmd1 Met Fn1 Rasal1 Dusp1 Psmd3 Psmd4 Pdpk1 Psmd6 Psmd5 Dusp2 Psmd7 Pik3r1 Dusp5 Psmd8 Fgf10 Pik3r2 Dusp4 ACYL CHAIN REMODELLING OF PC%REACTOME DATABASE ID RELEASE 59%1482788 Acyl chain remodelling of PC Pla2g5 Pla2g4d Pla2g4e Pla2g4f Mboat2 Pla2g2e Pla2g12a Pla2g2d Pla2g1b Pla2g2f Pnpla8 Lpcat4 Lpcat3 Pla2g6 Pla2g4a Pla2g10 Pla2r1 Pla2g16 Lpcat1 Lpcat2 Plbd1 Tmem86b Pla2g4c Pla2g3 Plb1 LACTOSE SYNTHESIS%REACTOME%R-HSA-5653890.1 Lactose synthesis Lalba B4galt1 Slc2a1 REACTIONS SPECIFIC TO THE COMPLEX N-GLYCAN SYNTHESIS PATHWAY%REACTOME%R-HSA-975578.3 Reactions specific to the complex N-glycan synthesis pathway Lhb Chst10 Chst8 Man2a1 Fut8 Mgat2 Fuca1 Cga PLATELET ADHESION TO EXPOSED COLLAGEN%REACTOME DATABASE ID RELEASE 59%75892 Platelet Adhesion to exposed collagen Fyn Gp1bb Gp1ba Itgb1 Fcer1g Gp5 Gp9 Gp6 Lyn Itga1 Itga2 Vwf Itga10 CYP2E1 REACTIONS%REACTOME DATABASE ID RELEASE 59%211999 CYP2E1 reactions Cyp2s1 Cyp2f2 Cyp2c65 Cyp2a5 Cyp2d22 Cyp2e1 Cyp2b10 Cyp2c50 GRB2 EVENTS IN EGFR SIGNALING%REACTOME%R-HSA-179812.1 GRB2 events in EGFR signaling Akap9 Ppp2r1a Csf2 Jak1 Frs2 Nras Frs3 Rasgrf1 Psmf1 Raf1 Psme4 Il5ra Fgf1 Il17rd Fgf2 Csk Cnksr1 Cnksr2 Erbb2 Fgf9 Ptk2 Fgf7 Psme3 Fgf6 Fgf4 Fgf3 Ppp5c Ranbp9 Ppp2cb Shc1 Lamtor2 Nrg2 Ppp2ca Shc3 Nrg1 Shc2 Psma7 Artn Nrtn Brap Psmb5 Psmb4 Ubc Nrg3 Psmb7 Nrg4 Psmb6 Psmb2 Psmb3 Psmb1 Mapk3 Mapk1 Ksr1 Ptpra Dusp16 Dusp10 Map3k11 Paqr3 Psme2 Psme1 Ncam1 Sos1 Braf Psmb10 Apbb1ip Psmb11 Csf2rb2 Rapgef2 Csf2ra Actn2 Nf1 Pdgfrb Pdgfra Kbtbd7 Il2rg Arrb2 Egfr Arrb1 Ret Vwf Sptan1 Pspn Map2k1 Rbx1 Fgg Map2k2 Cul3 Psmd12 Pdgfb Psmd11 Rasgef1a Psmd14 Rasa3 Rasa4 Psmd13 Psmd10 Il2 Rasa2 Rasa1 Nefl Spred3 Kit Spred2 Grin2a Spred1 Spta1 Il5 Ppp2r1b Sptbn4 Ywhab Kras Gdnf Shfm1 Irs2 Syngap1 Hbegf Irs1 Il3ra Btc Il2ra Il2rb Angpt1 Psmc6 Egf Fgf23 Psmc5 Fgf22 Mark3 Psmc2 Fgf20 Psmd2 Dab2ip Tek Psmb9 Psmb8 Araf Hras Grin1 Ppp2r5e Dlg4 Ppp2r5c Ppp2r5d Ppp2r5a Psmc1 Psmc4 Psmc3 Sptbn2 Itgb3 Sptbn1 Fyn Phb Grin2c Rasgrp4 Rasgrp3 Pebp1 Ppp2r5b Rasgrp1 Tln1 Fga Fgb Grin2d Grin2b Sptb Hgf Gfra2 Gfra3 Gfra4 Ereg Jak2 Pea15a Itga2b Rap1a Jak3 Wdr83 Camk2d Rap1b Camk2a Fgfr4 Camk2b Psma5 Rasal3 Rasal2 Psma4 Psma3 Psma6 Vcl Camk2g Psma2 Psma1 Gfra1 Psmd9 Dusp7 Iqgap1 Fgf16 Dusp6 Dusp9 Fgf15 Dusp8 Klb Fgf18 Psmd1 Met Fn1 Rasal1 Dusp1 Psmd3 Psmd4 Psmd6 Psmd5 Dusp2 Psmd7 Dusp5 Psmd8 Fgf10 Dusp4 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES)%REACTOME DATABASE ID RELEASE 59%1236978 Cross-presentation of soluble exogenous antigens (endosomes) Mrc2 Psmc6 Mrc1 Psmc5 Psmc2 Psmd2 Psmd12 Psma7 Psmd11 Psmb9 Psmf1 Psmb8 Psma5 Psme4 Psmd14 Psmb5 Psmb4 Psmd13 Psma4 Psmd10 Psmb7 Psma3 Psma6 Psmb6 Psmb2 Psmc1 Psmb3 Psmc4 Psmb1 Psma2 Psmc3 Psma1 Psme3 Cd207 Psmd9 Psmd1 Shfm1 Psme2 Fcgr1 Psme1 Psmd3 Psmd4 Psmb10 Psmd6 Psmd5 Psmd7 Psmb11 Psmd8 HS-GAG BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 59%2022928 HS-GAG biosynthesis Hs3st2 Agrn Hs3st5 Hs3st6 Hs3st4 Hs3st1 Ndst2 Hs6st1 Hs6st3 Hs6st2 Hs2st1 Glce Sdc3 Sdc4 Gpc6 Ext2 Ext1 Sdc2 Gpc3 Sdc1 Gpc5 Gpc2 Ndst3 Gpc4 Ndst1 Ndst4 Hs3st3a1 Slc35d2 Hs3st3b1 Hspg2 Gpc1 UB-SPECIFIC PROCESSING PROTEASES%REACTOME%R-HSA-5689880.2 Ub-specific processing proteases Rce1 Vdac1 Hist1h2aa Adrm1 Becn1 Ufd1l Ar Atxn7 Foxo4 Hist1h2af Mat2b Vdac2 Vdac3 Usp8 Usp42 Usp44 Arrb2 Mdm4 Smad1 Usp47 Arrb1 Usp48 Usp49 Siah2 Hist3h2a Hif1a Hist2h2ab Map3k7 Usp12 Il33 Usp37 Ddb2 Usp11 Usp33 Usp28 Tab1 Usp30 Smad4 Usp19 Smad2 Smad7 Usp13 Suds3 Usp14 Usp16 Ide Smad3 Hist2h2bb Usp5 Nfkbia Usp10 Hist2h2be Usp26 Usp20 Hgs Hist2h2ac Tomm70a Usp25 Kat2a Stam2 Usp22 Usp3 Hist1h2bg Hist1h2bh Axin1 Ripk1 Hist1h2bp Hist1h2bm Psmd12 Rnf146 Psmd11 Ruvbl1 Hist1h2bj Keap1 Hist1h2bb Fkbp8 Psmd14 Mul1 Wdr20 Psmd13 Rnf123 Psmd10 Gata3 Rnf128 Traf2 Wdr48 Birc3 Birc2 Tnks Traf6 Cdc20 Ptrh2 Tada3 Shfm1 Ikbkg Polb Tnks2 Hist1h2ak Mdm2 Pten Hist1h2ag Trrap Otub1 Hist1h2ah Psmc6 Psmc5 Ccp110 Usp9x Psmc2 Psmd2 Clspn Psmb9 Psmf1 Psmb8 Psme4 Psmc1 Ccna1 Psmc4 Psmc3 Skp2 Cdc25a Ccna2 Psme3 Taf9b Usp7 Hist3h2ba Adrb2 Axin2 Usp21 Cftr Psma7 Psma5 Psmb5 Psmb4 Ubc Ifih1 Psma4 Psma3 Psmb7 Myc Usp2 Psma6 Usp4 Cyld Psmb6 Psmb2 Psmb3 Psma2 Psmb1 Psma1 Psmd9 Usp18 Trp53 Hist2h2aa1 Rhot1 Psmd1 Psme2 Snx3 Psme1 Psmd3 Psmd4 Psmb10 Tgfbr1 Psmd6 Psmd5 Usp15 Psmd7 Smurf2 Psmb11 Ddx58 Psmd8 ALPHA-OXIDATION OF PHYTANATE%REACTOME DATABASE ID RELEASE 59%389599 Alpha-oxidation of phytanate Hacl1 Slc27a2 Phyh Slc25a17 COX REACTIONS%REACTOME%R-HSA-140180.1 COX reactions Ptgs1 BBSOME-MEDIATED CARGO-TARGETING TO CILIUM%REACTOME DATABASE ID RELEASE 59%5620922 BBSome-mediated cargo-targeting to cilium Cct2 Cct5 Tcp1 Cct8 Arl6 Cct3 Cct4 Bbs7 Smo Bbs9 Bbs5 Bbs4 Rab3ip Bbs2 Bbs1 Sstr3 Mchr1 Mkks Lztfl1 Ttc8 Bbs12 Bbs10 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS%REACTOME DATABASE ID RELEASE 59%1362409 Mitochondrial iron-sulfur cluster biogenesis Fdx1 Fdx1l Slc25a37 Lyrm4 Fxn Slc25a28 Fdxr NEGATIVE REGULATION OF FGFR1 SIGNALING%REACTOME%R-HSA-5654726.2 Negative regulation of FGFR1 signaling Ppp2cb Spry2 Fgf23 Fgf22 Ppp2ca Fgf20 Frs2 Ppp2r1a Mknk1 Braf Fgf1 Ubc Cbl Fgf2 Fgf9 Mapk3 Ptpn11 Fgf6 Fgf10 Fgf4 Mapk1 Fgf3 OXYGEN-DEPENDENT ASPARAGINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA%REACTOME DATABASE ID RELEASE 59%1234162 Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha Hif1an Epas1 Hif1a EPHRIN SIGNALING%REACTOME DATABASE ID RELEASE 59%3928664 Ephrin signaling Fyn Efnb3 Arhgef7 Efnb1 Rac1 Pak1 Sdcbp Pak3 Pak2 Nck2 Git1 Ephb1 Ephb4 Ephb2 Ephb6 Efnb2 Ephb3 REGULATION OF GENE EXPRESSION IN LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS%REACTOME%R-HSA-210744.1 Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells Hnf1b Notch1 Onecut3 Onecut1 Rbpj Neurog3 Hes1 ENDOGENOUS STEROLS%REACTOME%R-HSA-211976.3 Endogenous sterols Cyp21a1 Cyp7a1 Cyp7b1 Nr1h4 Cyp4v3 Ptgis Arnt Cyp19a1 Pomc Arnt2 Cyp11b1 Cyp8b1 Cyp11b2 Fdx1 Cyp17a1 Cyp51 Fdx1l Ahr Rxra Cyp11a1 Cyp1b1 Fdxr Cyp46a1 Cyp27a1 Cyp39a1 Ncoa1 Ncoa2 M G1 TRANSITION%REACTOME DATABASE ID RELEASE 59%68874 M G1 Transition Psmc6 Psmc5 Psmc2 Psmd2 Psmb9 Psmf1 Psmb8 Psme4 Mcm6 Cdc6 Cdk2 Mcm3 Mcm2 Mcm5 Mcm4 E2f1 Psmc1 Psmc4 Psmc3 Psme3 Gmnn Orc4 Orc5 Mcm8 E2f2 Mcm7 Pole Cdt1 Cdc45 E2f3 Orc2 Orc3 Orc6 Orc1 Prim1 Pole2 Rpa2 Rpa1 Rpa3 Pola1 Pola2 Pole4 Prim2 Pole3 Psmd12 Psma7 Psmd11 Psmd14 Psma5 Psmb5 Psmb4 Ubc Psmd13 Psmd10 Psma4 Psmb7 Psma3 Psma6 Psmb6 Psmb2 Cdc7 Psmb3 Psmb1 Dbf4 Psma2 Mcm10 Psma1 Psmd9 Psmd1 Shfm1 Psme2 Psme1 Psmd3 Psmd4 Psmb10 Psmd6 Psmd5 Psmd7 Psmb11 Psmd8 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY%REACTOME DATABASE ID RELEASE 59%2564830 Cytosolic iron-sulfur cluster assembly Fam96b Nubp2 Ndor1 Narfl Ciao1 Ciapin1 Pold1 Rtel1 Brip1 Mms19 Nubp1 Ercc2 SIGNALING BY INSULIN RECEPTOR%REACTOME%R-HSA-74752.1 Signaling by Insulin receptor Pik3c3 Prkaa2 Akap9 Ppp2r1a Pik3r4 Prkaa1 Csf2 Jak1 Tsc1 Atp6v0d2 Atp6v0d1 Atp6v0b Atp6v1c2 Atp6v1c1 Atp6v0e Atp6ap1 Atp6v1g3 Atp6v1e2 Atp6v1e1 Atp6v0e2 Atp6v1a Atp6v1b1 Tcirg1 Atp6v1b2 Atp6v1g1 Atp6v1g2 Atp6v0a1 Atp6v0a2 Atp6v1h Atp6v0a4 Atp6v1d Atp6v1f Prkag2 Prkag1 Prkag3 Frs2 Nras Frs3 Rasgrf1 Psmf1 Raf1 Psme4 Il5ra Fgf1 Il17rd Fgf2 Cnksr1 Csk Cnksr2 Erbb2 Fgf9 Ptk2 Fgf7 Psme3 Fgf6 Fgf4 Fgf3 Ppp5c Ranbp9 Lamtor1 Ppp2cb Shc1 Lamtor2 Ppm1a Nrg2 Tlr9 Ppp2ca Shc3 Lamtor5 Nrg1 Akt2 Shc2 Psma7 Artn Nrtn Lamtor4 Brap Psmb5 Psmb4 Ubc Nrg3 Psmb7 Nrg4 Psmb6 Psmb2 Psmb3 Psmb1 Prkab1 Mapk3 Akt1 Mapk1 Ksr1 Ptpra Dusp16 Dusp10 Stk11 Map3k11 Prkab2 Paqr3 Psme2 Psme1 Ncam1 Sos1 Braf Psmb10 Apbb1ip Psmb11 Csf2rb2 Rapgef2 Csf2ra Actn2 Nf1 Tsc2 Pdgfrb Pdgfra Mlst8 Kbtbd7 Il2rg Arrb2 Egfr Gab1 Arrb1 Mtor Ret Vwf Rptor Ins2 Sptan1 Pspn Pde3b Map2k1 Rbx1 Fgg Map2k2 Cul3 Rragd Psmd12 Rragb Pdgfb Rragc Psmd11 Rraga Rasgef1a Eif4b Psmd14 Rasa3 Rasa4 Psmd13 Psmd10 Il2 Rasa2 Rasa1 Nefl Spred3 Kit Spred2 Grin2a Spred1 Spta1 Il5 Sptbn4 Ppp2r1b Ywhab Kras Insr Gdnf Shfm1 Cab39 Eif4e Strada Irs2 Stradb Cab39l Syngap1 Eef2k Hbegf Eif4g1 Irs1 Eif4ebp1 Il3ra Btc Il2ra Il2rb Angpt1 Ptpn11 Trib3 Psmc6 Egf Fgf23 Psmc5 Fgf22 Mark3 Psmc2 Fgf20 Psmd2 Dab2ip Tek Psmb9 Psmb8 Araf Hras Grb10 Grin1 Ppp2r5e Dlg4 Ppp2r5c Ppp2r5d Ppp2r5a Psmc1 Psmc4 Psmc3 Pik3cb Sptbn2 Sptbn1 Itgb3 Fyn Phb Grin2c Rasgrp4 Rasgrp3 Pebp1 Ppp2r5b Rasgrp1 Tln1 Pik3ca Fga Fgb Grin2d Grin2b Sptb Hgf Gfra2 Gfra3 Gfra4 Ereg Jak2 Pea15a Itga2b Rap1a Jak3 Wdr83 Camk2d Rap1b Camk2a Fgfr4 Camk2b Psma5 Rasal3 Rasal2 Psma4 Psma3 Psma6 Akt1s1 Vcl Camk2g Psma2 Psma1 Gfra1 Psmd9 Dusp7 Iqgap1 Fgf16 Dusp6 Dusp9 Fgf15 Dusp8 Klb Fgf18 Them4 Psmd1 Met Fn1 Rasal1 Dusp1 Psmd3 Psmd4 Pdpk1 Psmd6 Psmd5 Dusp2 Psmd7 Pik3r1 Dusp5 Psmd8 Fgf10 Pik3r2 Dusp4 METALLOPROTEASE DUBS%REACTOME%R-HSA-5689901.2 Metalloprotease DUBs Fam175b Hist1h2aa Fam175a Mysm1 Hist1h2af Psmd14 Ubc Brcc3 Uimc1 Babam1 Hist3h2a Stambp Hist2h2ab Bre Hist2h2aa1 Bard1 Brca1 Hist1h2ak Stambpl1 Hist1h2ag Ep300 Stam Hist2h2ac Nlrp3 Kat2b Hist1h2ah SHC-MEDIATED CASCADE:FGFR3%REACTOME DATABASE ID RELEASE 59%5654704 SHC-mediated cascade:FGFR3 Sos1 Fgf1 Fgf23 Fgf16 Fgf2 Kras Fgf20 Fgf18 Nras Fgf9 Fgf4 Hras G1 PHASE%REACTOME DATABASE ID RELEASE 59%69236 G1 Phase Ppp2cb Ppp2ca Cdkn1a Ppp2r1a Rb1 Rbl2 Cdkn2c Rbl1 Ubc E2f5 Skp1a E2f4 Ccnd2 E2f1 Cdkn2a Skp2 Cdkn1c Cul1 Cdk4 Cdkn2b Tfdp2 Cks1b Tfdp1 Ccnd1 Cdk6 Ppp2r1b E2f2 Mnat1 Ccnd3 E2f3 Ccnh Ppp2r2a Cdkn1b Cdk7 GABA A (RHO) RECEPTOR ACTIVATION%REACTOME%R-HSA-977442.1 GABA A (rho) receptor activation Gabrr2 Gabrr3 Gabrr1 BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS%REACTOME DATABASE ID RELEASE 59%390247 Beta-oxidation of very long chain fatty acids Abcd1 Acaa1a Hsd17b4 Crat Acot8 ATF6 (ATF6-ALPHA) ACTIVATES CHAPERONE GENES%REACTOME%R-HSA-381183.2 ATF6 (ATF6-alpha) activates chaperone genes Ddit3 Hsp90b1 Nfyb Nfyc Calr Atf6 Hspa5 Atf4 Nfya POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA%REACTOME%R-HSA-112296.3 Post-Elongation Processing of Intron-Containing pre-mRNA Pabpn1 Srsf2 Thoc7 Thoc6 Srsf3 Slu7 Srsf11 Zc3h11a Magoh Cpsf1 Cstf1 Dhx38 Clp1 Thoc3 Srsf7 Thoc2 Thoc5 Thoc1 Srsf9 Ncbp1 Alyref Ncbp2 Srsf6 Nudt21 Cstf2t Fip1l1 Rbm8a Cstf3 Casc3 Sympk Eif4a3 U2af1l4 Chtop Srsf1 Cstf2 Cpsf3 Cpsf2 Cpsf4 Cpsf7 Ddx39b Upf3b Ddx39 Papola Fyttd1 Wdr33 Rnps1 Poldip3 Magohb Cdc40 Srrm1 FORMATION OF EDITOSOMES BY ADAR PROTEINS%REACTOME DATABASE ID RELEASE 59%77042 Formation of editosomes by ADAR proteins Adarb1 Adar ASTROCYTIC GLUTAMATE-GLUTAMINE UPTAKE AND METABOLISM%REACTOME%R-HSA-210455.2 Astrocytic Glutamate-Glutamine Uptake And Metabolism Slc1a3 Slc1a2 Glul Slc38a1 PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS%REACTOME%R-HSA-202427.5 Phosphorylation of CD3 and TCR zeta chains H2-Aa Ptprc Cd3d Cd3e H2-Eb1 Lck Pag1 Ptprj Csk Cd4 Ptpn22 Cd3g RRNA PROCESSING IN THE NUCLEUS AND CYTOSOL%REACTOME DATABASE ID RELEASE 59%8868773 rRNA processing in the nucleus and cytosol Nhp2 Bysl Rpp21 Rpp25 Trmt112 Rrp36 Rps27 Pdcd11 Riok2 Riok1 Krr1 Pwp2 Riok3 Heatr1 Pno1 Pelp1 Utp18 Exosc9 Exosc8 Utp11l Mphosph10 Exosc7 Utp15 Exosc5 Exosc4 Diexf Pes1 Dcaf13 Wbscr22 Cirh1a Nop56 Utp14a Tex10 Dimt1 Nol9 Nol6 Utp3 Eri1 Exosc3 Utp6 Exosc1 Nop58 Exosc2 Isg20l2 Xrn2 Bms1 Mphosph6 Ltv1 Utp20 Dhx37 Nop10 Wdr75 Bop1 Nop14 Nat10 Thumpd1 Nob1 Tbl3 Tsr1 Fbl Tsr3 Wdr3 Wdr12 Senp3 Wdr18 Wdr43 Wdr46 Emg1 Dkc1 Rpl39 Rplp1 Ddx52 Rpl7 Rps21 Noc4l Rplp2 Las1l Ddx49 Rps25 Ddx47 Rpl4 Rps26 Rps27l Rpl18a Rpl34 Rpl32 C1d Rpl26 Rpl24 Rps9 Rps7 Rps5 Imp4 Imp3 Nol11 Csnk1d Csnk1e Rrp9 Rpsa Rpl37 Rps4x Exosc10 Rpp14 Nop2 Rcl1 Gar1 Rpl22 Rpp30 Rpp38 Rpl10l Rpl23 Rpl39l Rpl13a Rpl22l1 Rps15a Rpl11 Rpl17 Rps3 Rpl19 Rpl18 Rpp40 Rps16 Rps14 Rps19 Rps18 Skiv2l2 Rps11 Rps10 BETA OXIDATION OF OCTANOYL-COA TO HEXANOYL-COA%REACTOME DATABASE ID RELEASE 59%77348 Beta oxidation of octanoyl-CoA to hexanoyl-CoA Echs1 Hadhb Acadm Hadha Hadh ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR%REACTOME%R-HSA-451308.1 Activation of Ca-permeable Kainate Receptor Dlg4 Grik5 Grik1 Grik4 Dlg1 Grik3 Grik2 Ncald Dlg3 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME DATABASE ID RELEASE 59%2197563 NOTCH2 intracellular domain regulates transcription Creb1 Maml1 Mamld1 Fcer2a Ep300 Gzmb Maml3 Rbpj Hes5 Maml2 Notch2 Hes1 ABASIC SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 59%73930 Abasic sugar-phosphate removal via the single-nucleotide replacement pathway Apex1 Polb DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG%REACTOME%R-HSA-3359469.1 Defective MTR causes methylmalonic aciduria and homocystinuria type cblG Mtrr Mtr P53-DEPENDENT G1 DNA DAMAGE RESPONSE%REACTOME%R-HSA-69563.3 p53-Dependent G1 DNA Damage Response Psmc6 Psmc5 Psmc2 Psmd2 Psmb9 Psmb8 Psmf1 Psme4 Ccne1 Mdm4 Cdk2 Ccne2 Psmc1 Ccna1 Psmc4 Psmc3 Ccna2 Psme3 Chek2 Atm Cdkn1b Cdkn1a Psmd12 Psma7 Psmd11 Psmd14 Psma5 Psmb5 Psmb4 Psmd13 Ubc Psmd10 Psma4 Psmb7 Psma3 Pcbp4 Psma6 Psmb6 Psmb2 Psmb3 Psmb1 Psma2 Psma1 Zfp385a Psmd9 Trp53 Psmd1 Shfm1 Psme2 Psme1 Rfwd2 Psmd3 Psmd4 Mdm2 Psmb10 Psmd6 Psmd5 Psmd7 Psmb11 Psmd8 DEFECTIVE SLCO1B3 CAUSES HYPERBILIRUBINEMIA, ROTOR TYPE (HBLRR)%REACTOME DATABASE ID RELEASE 59%5619058 Defective SLCO1B3 causes hyperbilirubinemia, Rotor type (HBLRR) Alb RETINOID METABOLISM DISEASE EVENTS%REACTOME DATABASE ID RELEASE 59%6809583 Retinoid metabolism disease events Rbp4 TGFBR1 LBD MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 59%3656535 TGFBR1 LBD Mutants in Cancer Tgfbr1 Tgfb1 Fkbp1a Tgfbr2 GOLGI ASSOCIATED VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 59%432722 Golgi Associated Vesicle Biogenesis Golgb1 Pik3c2a Rab5c Ap3b1 Arrb1 Arf1 Fth1 Ftl1 Ocrl Bloc1s4 Tbc1d8b Bloc1s3 Vamp8 Bloc1s6 Hspa8 Necap1 Acbd3 Hip1r Picalm Dtnbp1 Cpd Pum1 Gak Igf2r Sh3gl2 Dnm2 Napa Tfrc Ap4b1 Ap1s2 Clint1 Ap1b1 Tpd52l1 Bloc1s1 Ap1s1 Sort1 Ap1g1 Snx2 Dnajc6 Ap3s1 Sh3d19 Yipf6 Snapin Ap1s3 Ap4e1 Vamp7 Vamp2 Txndc5 Snx9 Snx5 Ap1m2 Ap1m1 AUF1 (HNRNP D0) BINDS AND DESTABILIZES MRNA%REACTOME DATABASE ID RELEASE 59%450408 AUF1 (hnRNP D0) binds and destabilizes mRNA Psmc6 Psmc5 Psmc2 Psmd2 Psmb9 Psmb8 Psmf1 Psme4 Psmc1 Psmc4 Psmc3 Psme3 Hspa1a Hspb1 Hspa8 Psmd12 Psma7 Psmd11 Psmd14 Psma5 Psmb5 Psmb4 Psmd13 Ubc Psmd10 Psma4 Psma3 Psmb7 Psma6 Psmb6 Psmb2 Psmb3 Psma2 Psmb1 Psma1 Psmd9 Psmd1 Psme2 Shfm1 Psme1 Psmd3 Psmd4 Psmb10 Psmd6 Psmd5 Pabpc1 Eif4g1 Psmd7 Psmb11 Psmd8 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES%REACTOME DATABASE ID RELEASE 59%168180 TRAF6 Mediated Induction of proinflammatory cytokines Ppp2r1a Btrc Mapk9 Nfkb2 Nfkb1 Fbxw11 Skp1a Saa3 Ppp2r5d Mapkapk3 Tnip2 Myd88 Nod2 Cul1 Nod1 Dhx9 Vrk3 Elk1 S100b Mef2c Mapk10 Mef2a Map3k7 Dusp3 Mapk7 Creb1 Mapkapk2 Irak2 Irak1 App Map2k6 Tab1 Tab2 Jun Mapk8 Tab3 Ripk2 Map2k7 Ager Map2k3 Map2k4 Map3k8 Atf2 Rela Nfkbia Nfkbib Fos Ppp2cb Map2k1 Chuk Ppp2ca Ubc Mapk3 Rps6ka5 Mapk1 Ppp2r1b Ticam2 Dusp7 Rps6ka3 Rps6ka2 Dusp6 Ticam1 Rps6ka1 Traf6 Ikbkb Ube2v1 Tlr4 Ube2n Tlr3 Ly96 Cd14 Ikbkg Mapk11 Mapk14 Dusp4 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION%REACTOME DATABASE ID RELEASE 59%381340 Transcriptional regulation of white adipocyte differentiation Egr2 Cdk19 Helz2 Srebf2 Cdk8 Ccnc Med13 Fam120b Med14 Thrap3 Med12 Med10 Nfkb1 Chd9 Med16 Med17 Slc2a4 Med15 Cdk4 Klf4 Plin1 Wnt10b Ncor1 Fabp4 Pck1 Ccnd3 Ncor2 Rela Crebbp Med13l Ep300 Lep Smarcd3 Ncoa3 Wnt1 Med22 Med20 Med31 Tnf Med1 Med28 Adipoq Ppara Med27 Med29 Tbl1x Med26 Cebpb Med30 Pparg Med21 Med11 Med19 Med23 Med24 Med25 Ebf1 Lpl Nr2f2 Zfp638 Ppargc1a Med4 Med8 Med6 Havcr2 Zfp467 Klf5 Cebpa Tgfb1 Med9 Rxra Carm1 Med18 Cd36 Ncoa1 Angptl4 Ncoa6 Ncoa2 Tbl1xr1 Hdac3 RNA POLYMERASE III TRANSCRIPTION%REACTOME DATABASE ID RELEASE 59%74158 RNA Polymerase III Transcription Brf2 Nfia Nfic Ssb Pou2f1 Nfix Zfp143 Polr2f Polr2e Polr2h Tbp Gtf3c1 Gtf3c6 Gtf3c3 Gtf3c2 Bdp1 Gtf3c4 Polr2k Crcp Polr3a Polr3gl Snapc2 Polr3k Snapc1 Snapc4 Polr3h Brf1 Polr3f Polr3g Snapc5 Gtf3c5 Polr1d Polr1c Polr3d Polr3e Snapc3 Polr3b Gtf3a Polr3c VLDLR INTERNALISATION AND DEGRADATION%REACTOME DATABASE ID RELEASE 59%8866427 VLDLR internalisation and degradation Ap2a2 Cltc Ap2m1 Mylip Nr1h2 Nr1h3 Pcsk9 Clta Ap2b1 Ap2s1 Ap2a1 Vldlr PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC%REACTOME%R-HSA-389957.1 Prefoldin mediated transfer of substrate to CCT TriC Cct5 Tcp1 Tubb6 Cct8 Cct4 Vbp1 Cct7 Tubb3 Tuba1a Tubb1 Actb Tubb2b Tubb2a Pfdn2 Tuba3b Pfdn6 Tuba1c Pfdn1 Pfdn4 Pfdn5 Cct2 Tubb4a Cct6b Tubb4b Cct3 Tuba4a UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1%REACTOME%R-HSA-69229.2 Ubiquitin-dependent degradation of Cyclin D1 Psmc6 Psmc5 Psmc2 Psmd2 Psmd12 Psma7 Psmd11 Psmb9 Psmf1 Psmb8 Psma5 Psme4 Psmd14 Psmb5 Psmb4 Ubc Psmd13 Psma4 Psmd10 Psmb7 Psma3 Psma6 Psmb6 Psmb2 Psmc1 Psmb3 Psmc4 Psmb1 Psma2 Psmc3 Psma1 Cdk4 Psme3 Ccnd1 Psmd9 Psmd1 Shfm1 Psme2 Psme1 Psmd3 Psmd4 Psmb10 Psmd6 Psmd5 Psmd7 Psmb11 Psmd8 GENE SILENCING BY RNA%REACTOME DATABASE ID RELEASE 59%211000 Gene Silencing by RNA Nup85 Nup160 Nup50 Tpr Hsp90aa1 Ndc1 Nup214 Hist2h3c1 Aaas Nup210 Nup188 Nup54 Tsnax Nup35 Nupl2 Nup62 Nup205 Nup155 Nup88 Pom121 H2afj Rae1 H2afb2 Polr2f Polr2i Polr2e Polr2j Polr2h Tdrd12 Nup93 Polr2c Polr2d Polr2b Nup153 Henmt1 Piwil4 Asz1 Polr2g Polr2k Piwil1 Piwil2 Hist2h2be Hist3h2ba Tdrd9 Nup107 Tdrd6 Mael Polr2a Drosha Tarbp2 Hist2h2ac Ran Ipo8 Dgcr8 H3f3b Xpo5 H3f3a Prkra Dicer1 Hist1h2bg Hist1h2bh Nup37 Hist1h2bp Hist1h2bm Nup43 Nup133 Hist1h2bj Tdrd1 Hist1h2bb H2afz H2afx Ago2 Ago1 Tnrc6c Hist2h2aa1 Tnrc6b Hist1h3d Tnrc6a Ago4 Tsn Ago3 Tdrkh Hist1h2ak Mybl1 Fkbp6 Ranbp2 Hist1h2ag Mov10l1 Ddx4 Hist1h2ah TICAM1 DEFICIENCY - HSE%REACTOME DATABASE ID RELEASE 59%5602566 TICAM1 deficiency - HSE Ticam1 Tlr3 P75NTR NEGATIVELY REGULATES CELL CYCLE VIA SC1%REACTOME%R-HSA-193670.1 p75NTR negatively regulates cell cycle via SC1 Ngf Hdac2 Prdm4 Hdac1 Ngfr Hdac3 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS%REACTOME DATABASE ID RELEASE 59%2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants Hdac4 Hdac5 Ccnc Cdk8 Notch1 Skp1a Hdac1 Cul1 Maml2 Aph1b Maml1 Hdac2 Ncor1 Ncor2 Mib2 Crebbp Hdac10 Neurl1a Neurl1b Hey1 Hdac11 Ep300 Hey2 Hdac7 Hdac6 Hdac9 Hdac8 Hes5 Rbpj Kat2b Mib1 Kat2a Heyl Hes1 Adam10 Rbx1 Tbl1x Maml3 Ubc Myc Psen2 Ncstn Mamld1 Adam17 Jag2 Dll1 Tbl1xr1 Dll4 Jag1 Hdac3 TP53 REGULATES METABOLIC GENES%REACTOME%R-HSA-5628897.4 TP53 Regulates Metabolic Genes Prkag2 Prkag1 Prkag3 Prkaa2 Tsc2 Prdx2 Prdx1 Ywhag Ywhae Mlst8 Rrm2b G6pdx Mtor Ddit4 Cox4i1 Prkaa1 Gls2 Rptor Lrpprc Trp63 Cox6a1 Gls mt-Co1 Gpx2 Lamtor1 Cox6b1 Cox20 Txnrd1 Cox8a mt-Co3 Lamtor2 mt-Co2 Txn1 Ywhaz Lamtor5 Ywhah Sfn Akt2 Rragd Akt3 Rragb Rragc Rraga Tsc1 Cox7a2l Lamtor4 Cox14 Cox7b Cox11 Cox16 Sco1 Prkab1 Akt1 Ndufa4 Cox18 Ywhab Ago2 Tigar Ago1 Tnrc6c Prkab2 Trp53 Tnrc6b Tnrc6a Ago4 Taco1 Ago3 Sesn2 Cox5a Sesn3 Pten Gpi1 Surf1 Mov10 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE%REACTOME%R-HSA-77075.2 RNA Pol II CTD phosphorylation and interaction with CE Gtf2h5 Gtf2h4 Gtf2h3 Ercc3 Rngtt Rnmt Ercc2 Polr2i Polr2f Polr2j Polr2e Polr2h Polr2c Mnat1 Polr2d Polr2b Polr2k Polr2g Ccnh Polr2a Cdk7 Supt5 Gtf2f1 Gtf2h1 Gtf2f2 Gtf2h2 MEIOSIS%REACTOME DATABASE ID RELEASE 59%1500620 Meiosis Lmnb1 Hist2h3c1 Spo11 Cdk2 Mnd1 Tex15 Msh5 Msh4 Rad50 Rad51c Cdk4 H2afj H2afb2 Nbn Stag2 Rpa2 Rpa1 Mre11a Stag1 Atm Hist2h2be Hist3h2ba Rpa3 Hspa2 Smc1a Top3a Mlh1 Hist2h2ac Rad21 Ube2i H3f3b H3f3a Brca2 Hist1h2bg Tinf2 Pot1a Hist1h2bh Terf1 Terf2 Hist1h2bp Acd Hist1h2bm Rbbp8 Hist1h2bj Hist1h2bb Blm H2afz Terf2ip H2afx Smc3 Syne1 Rad51 Syce3 Psmc3ip Syce2 Hist2h2aa1 Syne2 Dmc1 Syce1 Mlh3 Hist1h3d Hist1h3h Brca1 Smc1b Hist1h2ak Fkbp6 Hist1h2ag Sun1 Sycp3 Stag3 Rec8 Prdm9 Sycp2 Sycp1 Hist1h2ah Sun2 Tex12 HOST INTERACTIONS WITH INFLUENZA FACTORS%REACTOME%R-HSA-168253.3 Host Interactions with Influenza Factors Nup85 Nup160 Nup37 Nup50 Nup43 Tpr Isg15 Nup133 Cpsf4 Ndc1 Nup214 Aaas Nup210 Nup188 Nup54 Nup35 Nupl2 Nup62 Nup205 Nup155 Nup88 Pom121 Rae1 Pabpn1 Nup93 Tgfb1 Nup153 Kpnb1 Kpna1 Ranbp2 Nup107 Kpna3 Kpna4 Kpna7 Slc25a5 Eif2ak2 TRUNCATED APC MUTANTS DESTABILIZE THE DESTRUCTION COMPLEX%REACTOME%R-HSA-4839744.1 truncated APC mutants destabilize the destruction complex Ppp2r1b Ppp2cb Apc Axin1 Ppp2ca Amer1 Csnk1a1 Gsk3b Ppp2r1a Ppp2r5b Ppp2r5e Ppp2r5c Ppp2r5d Ppp2r5a GLUCOCORTICOID BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 59%194002 Glucocorticoid biosynthesis Cyp17a1 Cyp21a1 Hsd11b1 Hsd11b2 Pomc Hsd3b1 Hsd3b6 Cyp11b1 Cyp11b2 G ALPHA (Q) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 59%416476 G alpha (q) signalling events Trpc6 Prkcd Ffar3 Prkce Nts Dgkb Npff Arhgef25 Dgka Saa3 Ptger1 Adrbk1 Dgke Dgkg App Htr2a Htr2b Htr2c Gpr132 Prok1 Rasgrp2 Mchr1 Prok2 Trio Trpc3 Ffar2 Ffar1 Agtr1a Trpc7 Daglb Pmch Ednra Ednrb Prokr1 Agt Prokr2 Qrfp Dagla Hcrtr1 Anxa1 Hcrtr2 Ptafr Nmur1 Nmur2 Cckar Prkcq Xcl1 Gpr17 Fpr2 Mgll Prkch P2ry1 P2ry2 Tac2 Tac1 Gnrhr Itpr1 Avp Avpr1a Hrh1 Gast Avpr1b Npffr1 Cck Npffr2 Cckbr P2ry6 Itpr3 Rgs2 Rgs3 Itpr2 Gngt1 Grp Gng7 Rgs18 Abhd12 Gng4 Tbxa2r Gcg Rgs19 Gngt2 F2rl3 F2rl2 Gng10 Nmb Gcgr Qrfpr Gpr4 Nmu Oxt Chrm3 Chrm1 Rgs21 Trhr Kiss1r Nms Gprc6a Kiss1 F2rl1 Chrm5 Grpr Ptgfr Ntsr1 Ntsr2 Xcr1 Ghsr Uts2b Uts2r Rasgrp1 Pik3ca Opn4 Gng11 Casr Gng13 Gng12 Gnb2 Trh Gnb1 Gnb3 Gnb5 Gnb4 Gna11 Gng8 F2r Nmbr Gnaq Gna15 Edn1 Gng3 F2 Gng2 Nps Edn3 Gna14 Edn2 Cysltr1 Adra1a Adra1b Adra1d Lpar5 Dgkq Grk5 Lpar3 Lpar4 Lpar1 P2ry10 Lpar2 Plcb1 Dgkh Plcb2 Uts2 Brs3 Hcrt Dgki Npsr1 Ltb4r2 Grm1 Ltb4r1 Grm5 Lpar6 Tacr2 Tacr3 Bdkrb1 Tacr1 Cysltr2 Bdkrb2 Kng2 Rgsl1 Gpr68 Gpr65 Gnrh1 Kalrn Abhd6 Plcb4 Plcb3 Pik3r3 Dgkz Pik3r1 Ppan Pik3r2 Oxtr XENOBIOTICS%REACTOME%R-HSA-211981.1 Xenobiotics Cyp2s1 Ahr Cyp2w1 Cyp2j6 Cyp2f2 Cyp2c65 Cyp2b10 Cyp3a57 Cyp1a2 Cyp3a16 Cyp3a13 Arnt Cyp2a5 Cyp1a1 Cyp2d22 Cyp2e1 Arnt2 Cyp2c50 Cyp2c55 PKA-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%R-HSA-111931.1 PKA-mediated phosphorylation of CREB Adcy7 Adcy6 Creb1 Adcy5 Adcy4 Adcy3 Adcy2 Prkar2a Adcy1 Prkacb Adcy9 Adcy8 Prkar2b Prkar1a Prkar1b Prkaca INFLAMMASOMES%REACTOME%R-HSA-622312.1 Inflammasomes Aim2 Bcl2 Txn1 App Bcl2l1 Nlrp1a Pycard Txnip Panx1 Sugt1 Rela Nfkb2 P2rx7 Nfkb1 Pstpip1 Hsp90ab1 Nlrc4 Casp1 Nlrp3 Mefv HEME DEGRADATION%REACTOME%R-HSA-189483.1 Heme degradation Ugt1a5 Ugt1a1 Hmox1 Blvrb Blvra Hmox2 MISMATCH REPAIR (MMR) DIRECTED BY MSH2:MSH6 (MUTSALPHA)%REACTOME%R-HSA-5358565.1 Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Msh6 Pold1 Pold2 Pold3 Pcna Pold4 Rsph10b Msh2 Rpa2 Rpa1 Rpa3 Mlh1 Lig1 Exo1 Pms2 TYPE I HEMIDESMOSOME ASSEMBLY%REACTOME%R-HSA-446107.1 Type I hemidesmosome assembly Cd151 Itga6 Itgb4 Plec Col17a1 Lamb3 Lama3 Lamc2 ACYL CHAIN REMODELING OF DAG AND TAG%REACTOME%R-HSA-1482883.3 Acyl chain remodeling of DAG and TAG Pnpla2 Dgat2 Dgat2l6 Pnpla3 Dgat1 Awat2 Mgll SYNTHESIS AND PROCESSING OF ENV AND VPU%REACTOME DATABASE ID RELEASE 59%171286 Synthesis and processing of ENV and VPU Furin RHO GTPASES ACTIVATE CIT%REACTOME%R-HSA-5625900.1 RHO GTPases activate CIT Rac1 Kif14 Myl12b Myl12a Myl6 Myh11 Dlg4 Cdkn1b Rhoa Prc1 Rhob Myh9 Myh14 Myh10 Rhoc Cit IRF3 MEDIATED ACTIVATION OF TYPE 1 IFN%REACTOME%R-HSA-1606341.1 IRF3 mediated activation of type 1 IFN Tbk1 Nlrp4e Dtx4 Zbp1 Irf3 PROLONGED ERK ACTIVATION EVENTS%REACTOME%R-HSA-169893.1 Prolonged ERK activation events Akap9 Ppp2r1a Csf2 Jak1 Frs2 Nras Frs3 Rasgrf1 Psmf1 Raf1 Psme4 Il5ra Fgf1 Il17rd Fgf2 Cnksr1 Csk Cnksr2 Erbb2 Fgf9 Ptk2 Fgf7 Psme3 Fgf6 Fgf4 Fgf3 Ppp5c Ranbp9 Ppp2cb Shc1 Lamtor2 Nrg2 Ppp2ca Shc3 Nrg1 Shc2 Psma7 Artn Nrtn Plcg1 Brap Psmb5 Psmb4 Ubc Nrg3 Psmb7 Nrg4 Psmb6 Psmb2 Psmb3 Psmb1 Mapk3 Mapk1 Ksr1 Ptpra Dusp16 Dusp10 Map3k11 Paqr3 Psme2 Psme1 Ncam1 Sos1 Braf Psmb10 Apbb1ip Rapgef1 Psmb11 Csf2rb2 Rapgef2 Csf2ra Actn2 Nf1 Pdgfrb Pdgfra Kbtbd7 Il2rg Arrb2 Egfr Arrb1 Ret Ntrk1 Vwf Sptan1 Pspn Map2k1 Rbx1 Crkl Fgg Map2k2 Cul3 Psmd12 Pdgfb Psmd11 Rasgef1a Psmd14 Rasa3 Rasa4 Psmd13 Psmd10 Il2 Rasa2 Rasa1 Nefl Spred3 Kit Spred2 Grin2a Spred1 Spta1 Il5 Ppp2r1b Sptbn4 Ywhab Kras Gdnf Shfm1 Irs2 Syngap1 Hbegf Irs1 Il3ra Btc Il2ra Il2rb Angpt1 Psmc6 Egf Fgf23 Psmc5 Fgf22 Mark3 Psmc2 Fgf20 Psmd2 Dab2ip Tek Psmb9 Psmb8 Araf Hras Grin1 Ppp2r5e Dlg4 Ppp2r5c Ppp2r5d Ppp2r5a Psmc1 Psmc4 Psmc3 Sptbn2 Itgb3 Sptbn1 Fyn Phb Grin2c Rasgrp4 Rasgrp3 Pebp1 Ppp2r5b Rasgrp1 Tln1 Fga Fgb Grin2d Grin2b Sptb Hgf Gfra2 Gfra3 Gfra4 Ereg Jak2 Pea15a Itga2b Rap1a Jak3 Wdr83 Camk2d Rap1b Camk2a Fgfr4 Camk2b Psma5 Rasal3 Rasal2 Psma4 Psma3 Psma6 Vcl Camk2g Psma2 Psma1 Gfra1 Psmd9 Ngf Dusp7 Iqgap1 Fgf16 Dusp6 Dusp9 Fgf15 Dusp8 Klb Fgf18 Psmd1 Met Kidins220 Fn1 Rasal1 Dusp1 Psmd3 Psmd4 Psmd6 Psmd5 Dusp2 Psmd7 Crk Dusp5 Psmd8 Fgf10 Dusp4 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATION FROM THE CENTROSOME%REACTOME%R-HSA-380284.1 Loss of proteins required for interphase microtubule organization from the centrosome Pafah1b1 Ccp110 Nek2 Cep57 Akap9 Haus7 Haus8 Ppp2r1a Ywhag Ywhae Hsp90aa1 Ninl Ywhaq Cep152 Prkar2b Haus3 Haus4 Cdk1 Cetn2 Ofd1 Haus2 Cep63 Alms1 Haus5 Haus6 Haus1 Tubb4a Tubb4b Clasp1 Ssna1 Tubg1 Csnk1d Cep250 Tuba4a Dynll1 Csnk1e Cep135 Cdk5rap2 Mapre1 Pcnt Sfi1 Cep70 Nedd1 Actr1a Cep131 Pcm1 Prkaca Dync1i2 Fgfr1op Cep76 Cep78 Cep72 Dctn2 Dctn3 Ckap5 Cep164 Tubb5 Tuba1a Cep41 Plk1 Cenpj Dync1h1 Plk4 Sdccag8 MET ACTIVATES RAS SIGNALING%REACTOME%R-HSA-8851805.1 MET activates RAS signaling Sos1 Ranbp10 Muc20 Kras Ranbp9 Nras Met Hgf Hras POST-CHAPERONIN TUBULIN FOLDING PATHWAY%REACTOME%R-HSA-389977.1 Post-chaperonin tubulin folding pathway Tubb4a Tubb4b Tubb6 Tubb3 Tubb1 Tuba1a Tuba4a Tubb2b Tubal3 Tubb2a Tuba8 Tbcb Tuba1b Tuba3b Tbca Tuba1c Tbcc Arl2 Tbce Tbcd REGULATION OF INSULIN SECRETION%REACTOME DATABASE ID RELEASE 59%422356 Regulation of insulin secretion Gngt1 Gng7 Adcy6 Akap5 Adcy5 Gng4 Gcg Gngt2 Prkar2a Glp1r Prkacb Gng10 Adcy8 Prkca Rapgef4 Chrm3 Rapgef3 Prkar2b Kcnb1 Arl2 Kcns3 Arl2bp Kcng2 Kcnc2 Slc2a2 Slc2a1 Gnai2 Gnai1 Ins2 Slc25a4 Gng11 Gng13 Gng12 Gnb2 Gnb1 Gnb3 Prkar1a Gnb5 Prkar1b Gnb4 Gna11 Prkaca Gng8 Gnaq Gna15 Slc25a5 Gng3 Ffar1 Gng2 Gna14 Rap1a Plcb1 Plcb2 Snap25 Stxbp1 Adra2a Adra2c Cacna1e Cacna1a Iqgap1 Cacnb2 Cacnb3 Cacna2d2 Cacna1c Cacna1d Itpr1 Kcnj11 Abcc8 Plcb3 Marcks Ahcyl1 Syt5 Vamp2 Itpr3 Itpr2 Stx1a U12 DEPENDENT SPLICING%REACTOME DATABASE ID RELEASE 59%72165 U12 Dependent Splicing Sf3b4 Lsm2 Sf3b3 Sf3b2 Srsf1 Snrnp200 Sf3b6 Sf3b5 Zrsr2 Ddx42 Sf3b1 Snrpd2 Snrpd1 Zcrb1 Snrpb Snrpd3 Txnl4a Polr2i Polr2f Polr2j Polr2e Ybx1 Polr2h Srsf2 Polr2c Polr2d Pdcd7 Polr2b Snrnp25 Polr2k Polr2g Zmat5 Snrnp35 Rnpc3 Eftud2 Prpf8 Prpf6 Ddx23 Polr2a Srsf7 Gtf2f1 Ncbp1 Ncbp2 Snrnp48 Gtf2f2 Snrnp40 Srsf6 CHROMATIN ORGANIZATION%REACTOME DATABASE ID RELEASE 59%4839726 Chromatin organization Hist1h2aa Suv39h1 Atxn7 Actb Kdm4c Hist1h2af Aebp2 Nfkb2 Nfkb1 Hist3h2a Hcfc1 H2afj Hist2h2ab H2afb2 Hdac2 Taf9 Rela Hist2h2bb Hdac10 Kdm1a Hist2h2be Ep300 Hist2h2ac Hdac8 Hist1h2bg Hist1h2bh Gm10094 Tbl1x Brwd1 Hist1h2bp Hist1h2bm Ruvbl2 Ruvbl1 Hist1h2bj Hist1h2bb Rbbp7 Kdm1b Taf12 Tada3 Hist1h3d Hist1h2ak Hist1h2ag Actl6a Trrap Hist1h2ah Kdm4a Kdm4b Hist2h3c1 Sap30l Kdm7a Clock Arid4a Rest Rbbp4 Chd3 Gps2 Chd4 Brms1 Cdk4 Ccnd1 Ncor1 Ncor2 Mbd3 Arid4b Taf6l Sap130 Smarcd3 Eed Whsc1 Ehmt2 Ehmt1 Suz12 Yeats4 Ep400 Kdm6a Brpf3 Brpf1 Ing5 Hdac1 Sap30 Suds3 Dnmt3a Mta1 Kat2b Kat2a Mta3 Usp22 Prmt7 Prmt6 Pbrm1 Arid2 Smarcc2 Smarcc1 Rcor1 Actl6b Smarca4 Ezh2 Smarca2 Arid1b Arid1a Setd8 Prmt3 Wdr77 Hmg20b Kat5 Gatad2a Carm1 Gatad2b Smarcb1 Smarcd2 Smarcd1 Wdr5 Coprs Smarce1 Meaf6 Tbl1xr1 Kmt2c Atf7ip Kmt2b Kat6a Nsd1 Suv39h2 Setdb2 Smyd3 Prdm16 Setdb1 Kmt2a Kmt2d Smyd2 Padi2 Phf20 Atf2 Crebbp Hist3h2ba Tada2a Supt7l Kat7 Kat8 Kansl1 Kansl3 Hat1 Kansl2 Jak2 Yeats2 Phf2 Kdm8 Phf8 Ing4 Arid5b Mina Kdm6b Ing3 Tada1 Pax3 Mbip Mta2 Elp3 Epc1 Elp4 Elp2 Kdm5b Elp5 Elp6 Morf4l2 Prmt5 H2afz Dmap1 Morf4l1 H2afx Vps72 Prmt1 Padi6 Kdm5a Kdm5c Kdm5d Jade1 Taf5l Kdm4d Jade2 Jade3 Msl1 Padi1 Hist2h2aa1 Padi4 Ak6 Padi3 Kdm3a Msl3 Msl2 Supt20 Kdm2a Kdm2b Mrgbp Kdm3b Zzz3 Suv420h1 Csrp2bp Suv420h2 Setd1a Supt3 Setd1b Ogt Ccdc101 Dot1l Eny2 Jmjd6 Ash2l Mecom Dr1 Dpy30 Ikbkap Rbbp5 Ncoa1 Whsc1l1 Brd8 Ash1l Prdm9 Setd2 Setd3 Setd6 Ncoa2 Hdac3 Setd7 DEFECTIVE CHST14 CAUSES EDS, MUSCULOCONTRACTURAL TYPE%REACTOME%R-HSA-3595174.1 Defective CHST14 causes EDS, musculocontractural type Bgn Dcn Bcan Ncan Vcan Cspg4 Cspg5 ORGANELLE BIOGENESIS AND MAINTENANCE%REACTOME%R-HSA-1852241.2 Organelle biogenesis and maintenance Prkaa2 Akap9 Nphp4 Ppp2r1a Ywhae Nrf1 Ninl Cep152 Atp5b Hcfc1 Crtc1 Mterf1b Ssbp1 Mchr1 Gabpa Hdac6 Sirt3 Polg2 Crtc3 Crtc2 Peo1 Pprc1 Med1 Nr1d1 Tbl1x Ift140 Ift122 Ift52 Ift172 Ift57 Wdr19 Ttc21b Dync2h1 Wdr35 Ift88 Prkag2 Prkag1 Prkag3 Trip11 Chd9 Rho Mef2c Mrps14 Mrps11 Mrps16 Mrpl41 Mrps9 Mrps15 Ncor1 Mrpl28 Mrps17 Tfam Mrpl35 Mtif3 Dap3 Mef2d Gadd45gip1 Mrps10 Eral1 Mrps12 Mrpl40 Mrpl38 Mrps5 Mrpl39 Mrps2 Mrpl32 Mrpl33 Mtif2 Mrpl34 Smarcd3 Mrpl36 Mrps6 Mrpl37 Mrps7 Mrps34 Mrpl20 Mrps31 Mrps30 Mrpl1 Exoc3 Ppara Exoc4 Mrpl16 Mrpl2 Mrpl17 Mrpl14 Exoc1 Mrpl3 Mrpl4 Exoc5 Exoc6 Mrpl12 Exoc8 Mrpl13 Tfb1m Exoc7 Mrpl10 Exoc2 Mrpl11 Mrpl9 Mrpl55 Ppargc1b Mrpl57 Mrpl19 Mrpl18 Chchd1 Mrpl54 Ppargc1a Mrpl30 Ptcd3 Mtrf1l Mtfmt Mrps18a Prkab1 Mrpl22 Mrpl21 Mrps18b Mrps18c Mrpl24 Cct2 Cct3 Mrpl51 Mrps23 Mrps22 Prkab2 Tfb2m Mrpl50 Mrps25 Mrpl53 Mrps24 Mrpl52 Mrps28 Aurkaip1 Mrps26 Mrps27 Tsfm Gfm2 Mrps21 Mrrf Mrpl47 Mrpl48 Gfm1 Ict1 Mrpl46 Mrpl43 Mrpl44 Mrpl49 Tufm Mrps33 Mrps35 Mrpl45 Cct5 Tcp1 Cct8 Cct4 Helz2 Mkks Ift43 Cys1 Ift46 Wdr60 Kif17 Bbs12 Pde6d Ift74 Bbs10 Arl3 Dynlrb1 Arl6 Dynlrb2 Smo Bbs7 Ttc26 Gm3448 Bbs9 Nphp3 Dync2li1 Bbs5 Bbs4 Bbs2 Bbs1 Tcte3 Atat1 Ttc30a1 Pkd1 Pkd2 Unc119b Cnga4 Asap1 Hspb11 Lztfl1 Ift27 Traf3ip1 Ttc8 Cnga2 Cluap1 Tnpo1 Rab11fip3 Ift22 Arl13b Kif3c Kif3b Kif3a Polrmt Gbf1 Rxra Carm1 Kifap3 Tbl1xr1 Pafah1b1 Mks1 Rpgrip1l Nphp1 Ccp110 Nek2 Cep57 Cc2d2a Haus7 Haus8 Ywhag Cep97 Rab3ip Hsp90aa1 Ywhaq Rab8a B9d2 Prkar2b Haus3 Haus4 Cdk1 Cep162 Cetn2 Dynll2 B9d1 Ofd1 Alas1 Haus2 Ahi1 Cep63 Arf4 Alms1 Haus5 Haus6 Haus1 Tubb4a Tubb4b Creb1 Iqcb1 Esrra Rab11a Clasp1 Tmem67 Ssna1 Tubg1 Csnk1d Cep250 Tuba4a Dynll1 Csnk1e Cep135 Kif24 Cdk5rap2 Atf2 Inpp5e Mapre1 Crebbp Pcnt Sstr3 Sfi1 Cep70 Nedd1 Actr1a Cep131 Fbf1 Pcm1 Prkaca Dync1i2 Fgfr1op Cep76 Cep78 Cep72 Sept2 Dctn2 C2cd3 Sclt1 Dctn3 Ckap5 Cep164 Tubb5 Tuba1a Ttbk2 Ift81 Cep41 Ift80 Plk1 Wdr34 Mark4 Tctex1d2 Cenpj Tctex1d1 Cep83 Rp2h Dync1h1 Ttc30b Cep89 Tctn3 Plk4 Sdccag8 Tctn1 Mapk11 Mapk12 Mapk14 Ncoa1 Ncoa6 Ncoa2 Hdac3 PAOS OXIDISE POLYAMINES TO AMINES%REACTOME DATABASE ID RELEASE 59%141334 PAOs oxidise polyamines to amines Paox TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS%REACTOME DATABASE ID RELEASE 59%174417 Telomere C-strand (Lagging Strand) Synthesis Pole Dna2 Pold1 Pold2 Pcna Pold3 Pold4 Prim1 Rfc5 Pole2 Rpa2 Rfc3 Rpa1 Rpa3 Rfc2 Pola1 Pola2 Lig1 Rfc4 Fen1 Pole4 Rfc1 Prim2 Pole3 SHC-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME DATABASE ID RELEASE 59%2428933 SHC-related events triggered by IGF1R Sos1 Igf1r Kras Igf2 Igf1 Nras Hras ACTIVATED TLR4 SIGNALLING%REACTOME DATABASE ID RELEASE 59%166054 Activated TLR4 signalling Tbk1 Ppp2r1a Btrc Mapk9 Ikbke Tank Nfkb2 Traf3 Nfkb1 Ecsit Fbxw11 Saa3 Mapkapk3 Tnip2 Myd88 Nod2 Nod1 Dhx9 S100b Mapk10 Map3k7 Sigirr Irak3 Peli1 Irak2 Mapkapk2 Irak1 App Tab1 Map2k6 Tab2 Mapk8 Tab3 Jun Map3k1 Ripk2 Map2k7 Ager Map2k3 Map2k4 Map3k8 Rela Nfkbia Peli3 Nfkbib Irak4 Peli2 Casp8 Fadd Map2k1 Ripk1 Tlr2 Tlr6 Socs1 Rps6ka5 Ppp2r1b Ticam2 Ube2d1 Ripk3 Rps6ka3 Birc3 Rps6ka2 Birc2 Ticam1 Rps6ka1 Traf6 Ikbkb Ube2v1 Tlr4 Ube2n Tlr3 Ly96 Cd14 Ikbkg Cd36 Tlr1 Tirap Ptpn11 Irf7 Irf3 Skp1a Ppp2r5d Cul1 Vrk3 Elk1 Mef2c Mef2a Dusp3 Mapk7 Creb1 Atf2 Fos Ppp2cb Chuk Ppp2ca Btk Ube2d3 Ubc Mapk3 Mapk1 Dusp7 Dusp6 Mapk11 Mapk14 Dusp4 FICOLINS BIND TO REPETITIVE CARBOHYDRATE STRUCTURES ON THE TARGET CELL SURFACE%REACTOME DATABASE ID RELEASE 59%2855086 Ficolins bind to repetitive carbohydrate structures on the target cell surface Fcnb SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%R-HSA-427359.1 SIRT1 negatively regulates rRNA Expression Hist1h2bg Hist1h2bh Suv39h1 Hist1h2bp Hist1h2bm Hist1h2bj Hist1h2bb Hist2h3c1 Taf1d H2afz H2afx Taf1c Taf1b Taf1a H2afj H2afb2 Sirt1 Tbp Hist2h2aa1 Hist1h3d Rrp8 Hist1h2ak Hist3h2ba Hist2h2be Hist1h2ag Hist2h2ac H3f3b H3f3a Hist1h2ah ERYTHROCYTES TAKE UP CARBON DIOXIDE AND RELEASE OXYGEN%REACTOME%R-HSA-1237044.2 Erythrocytes take up carbon dioxide and release oxygen Cyb5rl Aqp1 Hba-a1 Slc4a1 Car4 Car2 Hbb-bs Cyb5r2 Cyb5r1 Car1 Cyb5r4 Hbb-bt Rhag SEROTONIN NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 59%181429 Serotonin Neurotransmitter Release Cycle Snap25 Ppfia2 Ppfia1 Ppfia4 Syn3 Unc13b Syn1 Syn2 Rab3a Syt1 Slc18a2 Vamp2 Cplx1 Stx1a PLATELET HOMEOSTASIS%REACTOME%R-HSA-418346.2 Platelet homeostasis Gngt1 Gng7 Trpc6 Gng4 Gngt2 Ppp2r1a Gng10 Nos3 P2rx4 P2rx5 Ppp2r5e Pde10a Ppp2r5c Ppp2r5d Ppp2r5a Pla2g4a Gucy1b3 Stim1 Pde9a Gucy1a2 Gucy1a3 Orai1 Orai2 Prkg2 Pde5a Fgr Ppp2r5b Gng11 Pafah2 Gng13 P2rx2 Gng12 P2rx1 P2rx7 Gnb2 P2rx6 Gnb1 Gnb3 Gnb5 P2rx3 Gnb4 Kcnmb2 Trpc3 Gng8 Kcnma1 Gng3 Kcnmb4 Gng2 Apob Mrvi1 Trpc7 Kcnmb1 Ppp2cb Pde3b Ptgir Ppp2ca Slc8a2 Slc8a1 Slc8a3 Pecam1 Ppp2r1b Pde3a Atp2a1 Pde2a Atp2a3 Atp2a2 Pde1b Pde1a Itpr1 Nos1 Mapk14 Atp2b3 Atp2b4 Atp2b1 Ptpn6 Atp2b2 Nos2 Pde11a Sri Itpr3 Ptpn11 Itpr2 POU5F1 (OCT4), SOX2, NANOG ACTIVATE GENES RELATED TO PROLIFERATION%REACTOME%R-HSA-2892247.3 POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation Stat3 Sall1 Pou5f1 Sall4 Foxd3 Fgf2 Zic3 Sox2 Epha1 PHYSIOLOGICAL FACTORS%REACTOME%R-HSA-5578768.1 Physiological factors Hipk1 Nppa Nkx2-5 Corin Hipk2 Npr2 Tbx5 Wwtr1 Npr1 Gata4 Kat2b Nppc OXIDATIVE STRESS INDUCED SENESCENCE%REACTOME DATABASE ID RELEASE 59%2559580 Oxidative Stress Induced Senescence Suz12 Mapkapk5 Mapk9 Cdkn2c Hist2h3c1 Mdm4 E2f1 Mapkapk3 Rnf2 Rbbp4 Cdk4 Tfdp2 H2afj Tfdp1 Mapk10 Cdk6 H2afb2 Ring1 Mapkapk2 E2f2 Map2k6 Jun Mapk8 Map2k7 E2f3 Map2k3 Map2k4 Hist2h2be Hist3h2ba Fos Hist2h2ac H3f3b H3f3a Tnik Hist1h2bg Map3k5 Hist1h2bh Mink1 Txn1 Map4k4 Eed Cbx6 Hist1h2bp Hist1h2bm Kdm6b Hist1h2bj Ezh2 Rbbp7 Hist1h2bb Ubc H2afz Cdkn2a H2afx Mapk3 Cdkn2b Ifnb1 Mapk1 Ago1 Phc3 Tnrc6c Trp53 Hist2h2aa1 Tnrc6b Hist1h3d Tnrc6a Ago4 Phc2 Ago3 Phc1 Mapk11 Cbx4 Cbx8 Mdm2 Hist1h2ak Cbx2 Mapk14 Hist1h2ag Bmi1 Hist1h2ah Mov10 SIGNALING BY FGFR3 POINT MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 59%8853338 Signaling by FGFR3 point mutants in cancer Fgf23 Fgf16 Kras Fgf20 Frs2 Fgf18 Nras Fgfr3 Plcg1 Hras Pik3ca Sos1 Fgf1 Gab1 Fgf2 Fgf9 Pik3r1 Fgf4 HEME BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 59%189451 Heme biosynthesis Alad Hmbs Fech Alas1 Alas2 Uros Ppox Cox15 Urod Cox10 Cpox REPRESSION OF WNT TARGET GENES%REACTOME DATABASE ID RELEASE 59%4641265 Repression of WNT target genes Ctbp1 Tcf7l1 Tle3 Ctbp2 Aes Lef1 Hdac1 Tcf7 Tle1 Tcf7l2 Tle4 Tle2 ISG15 ANTIVIRAL MECHANISM%REACTOME%R-HSA-1169408.2 ISG15 antiviral mechanism Nup85 Ppm1b Nup160 Nup50 Isg15 Tpr Ube2l6 Trim25 Irf3 Ndc1 Nup214 Aaas Nup210 Nup188 Nup54 Pin1 Nup35 Nupl2 Nup62 Flnb Nup205 Nup155 Nup88 Pom121 Rae1 Nup93 Stat1 Nup153 Arih1 Uba7 Nup107 2010002M12Rik Jak1 Eif4a3 Nup37 Nup43 Nup133 Plcg1 Ubc Nedd4 Mapk3 Eif4a1 Eif4a2 Usp18 Ube2e1 Kpnb1 Ube2n Kpna1 Eif4e Ranbp2 Eif4g1 Eif4g2 Kpna3 Kpna4 Eif4e3 Eif4g3 Kpna7 Ddx58 Eif2ak2 SIGNALING BY FGFR3 IN DISEASE%REACTOME%R-HSA-5655332.2 Signaling by FGFR3 in disease Fgf23 Fgf16 Kras Fgf20 Frs2 Fgf18 Nras Fgfr3 Plcg1 Hras Pik3ca Sos1 Fgf1 Gab1 Fgf2 Fgf9 Pik3r1 Fgf4 CA2+ PATHWAY%REACTOME%R-HSA-4086398.3 Ca2+ pathway Gngt1 Gng7 Gng4 Nlk Gngt2 Gng10 Prkca Map3k7 Wnt11 Ppp3cb Prkg2 Ppp3ca Ppp3r1 Nfatc1 Gng11 Gng13 Pde6a Gng12 Gnb2 Pde6b Gnb1 Gnb3 Gnb5 Gnb4 Prkg1 Gng8 Wnt5a Gng3 Gng2 Pde6g Ctnnb1 Plcb1 Plcb2 Camk2a Tcf7l1 Ago2 Ago1 Tnrc6c Fzd6 Lef1 Tcf7 Tnrc6b Gnat2 Gnao1 Tnrc6a Ago4 Ago3 Itpr1 Plcb3 Fzd2 Fzd3 Fzd4 Fzd5 Itpr3 Tcf7l2 Itpr2 Mov10 PLATELET AGGREGATION (PLUG FORMATION)%REACTOME DATABASE ID RELEASE 59%76009 Platelet Aggregation (Plug Formation) Ptpn1 Thpo Shc1 Gp1bb Gp1ba Fgg Itga2b Rap1a Rap1b Gp5 Mpl Gp9 Rapgef4 Rapgef3 Adra2a Adra2c Adra2b Csk Ptk2 Vwf Akt1 Itgb3 Rasgrp1 Syk Fn1 Bcar1 Tln1 Sos1 Rasgrp2 Pdpk1 Apbb1ip Fga Fgb Crk F2 NGF PROCESSING%REACTOME DATABASE ID RELEASE 59%167060 NGF processing Furin Ngf Pcsk6 Pcsk5 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT%REACTOME%R-HSA-159236.3 Transport of Mature mRNA derived from an Intron-Containing Transcript Nup85 Nup160 Nup50 Tpr Ndc1 Nup214 Aaas Nup210 Nup188 Nup54 Nup35 Nupl2 Nup62 Nup205 Nup155 Nup88 Pom121 Rae1 Nup93 Srsf2 Thoc7 Thoc6 Nxt1 Srsf3 Nup153 Slu7 Srsf11 Zc3h11a Magoh Dhx38 Nup107 Thoc3 Srsf7 Thoc2 Thoc5 Thoc1 Srsf9 Ncbp1 Alyref Ncbp2 Srsf6 Rbm8a Casc3 Eif4a3 Nup37 U2af1l4 Chtop Nxf7 Nup43 Srsf1 Nup133 Nxf1 Ddx39b Upf3b Ddx39 Fyttd1 Rnps1 Poldip3 Magohb Cdc40 Srrm1 Ranbp2 PHOSPHATE BOND HYDROLYSIS BY NTPDASE PROTEINS%REACTOME%R-HSA-8850843.3 Phosphate bond hydrolysis by NTPDase proteins Entpd2 Entpd1 Entpd4 Entpd3 Gm21685 Entpd6 Entpd8 Entpd5 Entpd7 NR1D1 (REV-ERBA) REPRESSES GENE EXPRESSION%REACTOME DATABASE ID RELEASE 59%1368071 NR1D1 (REV-ERBA) represses gene expression Nr1d1 Ncor1 Hdac3 LRR FLII-INTERACTING PROTEIN 1 (LRRFIP1) ACTIVATES TYPE I IFN PRODUCTION%REACTOME%R-HSA-3134973.1 LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production Crebbp Ep300 Ctnnb1 Irf3 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6%REACTOME%R-HSA-69017.2 CDK-mediated phosphorylation and removal of Cdc6 Psmc6 Psmc5 Psmc2 Psmd2 Psmd12 Psma7 Psmd11 Psmb9 Psmf1 Psmb8 Psma5 Psme4 Psmd14 Psmb5 Psmb4 Cdc6 Ubc Psmd13 Cdk2 Psma4 Psmd10 Psmb7 Psma3 Psma6 Psmb6 Psmb2 Psmc1 Psmb3 Psmc4 Psmb1 Psma2 Psmc3 Psma1 Psme3 Psmd9 Psmd1 Shfm1 Psme2 Psme1 Psmd3 Psmd4 Psmb10 Psmd6 Psmd5 Psmd7 Psmb11 Psmd8 BICARBONATE TRANSPORTERS%REACTOME%R-HSA-425381.2 Bicarbonate transporters Slc4a3 Slc4a4 Slc4a2 Slc4a5 Slc4a10 Slc4a7 Slc4a9 Slc4a1 Slc4a8 Ahcyl2 REVERSAL OF ALKYLATION DAMAGE BY DNA DIOXYGENASES%REACTOME DATABASE ID RELEASE 59%73943 Reversal of alkylation damage by DNA dioxygenases Alkbh3 Ascc3 Alkbh2 Alkbh5 Ascc2 Ascc1 Fto UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A%REACTOME%R-HSA-69601.2 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A Psmc6 Psmc5 Psmc2 Psmd2 Psmb9 Psmb8 Psmf1 Psme4 Psmc1 Psmc4 Psmc3 Cdc25a Psme3 Chek2 Atm Chek1 Psmd12 Psmd11 Psma7 Psmd14 Psma5 Psmb5 Psmb4 Psmd13 Ubc Psmd10 Psma4 Psma3 Psmb7 Psma6 Psmb6 Psmb2 Psmb3 Psma2 Psmb1 Psma1 Psmd9 Psmd1 Psme2 Shfm1 Psme1 Psmd3 Psmd4 Psmb10 Psmd6 Psmd5 Psmd7 Psmb11 Psmd8 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME DATABASE ID RELEASE 59%3359462 Defective AMN causes hereditary megaloblastic anemia 1 Amn Cubn Gif AXONAL GROWTH INHIBITION (RHOA ACTIVATION)%REACTOME DATABASE ID RELEASE 59%193634 Axonal growth inhibition (RHOA activation) Arhgdia Mag Rhoa Arhgef1 Lingo1 Rtn4 Ngfr Omg RNA POLYMERASE III TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 59%73980 RNA Polymerase III Transcription Termination Polr2f Polr2e Polr2h Nfia Nfic Ssb Polr2k Crcp Polr3a Polr3gl Polr3k Nfix Polr3h Polr3f Polr3g Polr1d Polr1c Polr3d Polr3e Polr3b Polr3c RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS.%REACTOME DATABASE ID RELEASE 59%163200 Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. Ecsit Atp5b Cox4i1 Cyc1 Cox8a Uqcrc2 Uqcrc1 mt-Co3 Uqcrfs1 mt-Co2 Etfa Coq10b Uqcrb Coq10a Trap1 Uqcrq Etfdh mt-Cytb Uqcr10 Cox14 Cox7b Cox11 Cox16 Sco1 Cox18 Cox5a Ndufs5 Ndufs4 Ndufa13 Ndufs2 Ndufb11 Ndufb10 Ndufs7 Etfb Ndufs8 Ndufa11 Ndufs1 Ndufa10 Ndufa12 Ndufb2 Acad9 Ndufc2 Ndufc1 Ndufb4 Ndufb3 Ndufb6 Ndufb5 mt-Nd2 mt-Nd1 Timmdc1 Nubpl mt-Nd6 mt-Nd5 mt-Nd4 mt-Nd3 Atp5a1 Slc25a27 Ndufaf1 Ndufaf2 Ndufaf3 Ndufa1 Ndufa2 Ndufa3 Ndufa5 Lrpprc Ndufaf4 Ndufb9 Ndufb7 Yjefn3 Ndufb8 Tmem126b Cox6a1 Slc25a14 Ucp1 Ndufv3 Ucp3 Ndufv1 Ndufv2 Ucp2 mt-Co1 Ndufab1 Ndufa6 Ndufa7 Ndufaf5 Ndufaf6 Ndufa8 Ndufa9 Cox6b1 Ndufaf7 Cox20 Cox7a2l Atp5g3 Atp5k Atp5j mt-Atp6 Ndufa4 Atp5s Atp5d Atp5j2 Atp5c1 Taco1 Atp5f1 Sdhd Sdha Sdhc Sdhb Surf1 INTERLEUKIN-6 SIGNALING%REACTOME DATABASE ID RELEASE 59%1059683 Interleukin-6 signaling Stat3 Il6ra Il6 Jak1 Cbl Socs3 Jak2 Il6st Ptpn11 Tyk2 G-PROTEIN MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 59%112040 G-protein mediated events Adcy7 Adcy6 Prkcd Adcy5 Adcy4 Adcy3 Adcy2 Prkcg Prkar2a Adcy1 Prkacb Plcb1 Adcy9 Gnaz Plcb2 Adcy8 Prkca Prkar2b Adrbk1 Pla2g4a Mapk1 Gnai2 Creb1 Gnai1 Gnai3 Gnat1 Pde1c Camk4 Gnat2 Pde1b Gnat3 Gnao1 Pde1a Gnal Itpr1 Plcb4 Plcb3 Prkar1a Prkar1b Ahcyl1 Prkaca Itpr3 Itpr2 ARL13B-MEDIATED CILIARY TRAFFICKING OF INPP5E%REACTOME DATABASE ID RELEASE 59%5624958 ARL13B-mediated ciliary trafficking of INPP5E Pde6d Inpp5e Arl13b SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP)%REACTOME DATABASE ID RELEASE 59%2559582 Senescence-Associated Secretory Phenotype (SASP) Cdkn2c Hist2h3c1 Nfkb1 Cdk2 Ccna1 Ccna2 Cdk4 Anapc15 Anapc11 H2afj Anapc10 Cdk6 Fzr1 H2afb2 Mapk7 Jun Rela Il6 Hist2h2be Cdkn1b Hist3h2ba Fos Hist2h2ac H3f3b H3f3a Hist1h2bg Hist1h2bh Cdkn1a Cebpb Hist1h2bp Hist1h2bm Hist1h2bj Hist1h2bb Stat3 Ubc Igfbp7 H2afz Cdkn2a H2afx Mapk3 Cdkn2b Mapk1 Il1a Cdc23 Ube2d1 Rps6ka3 Rps6ka2 Cdc27 Rps6ka1 Hist2h2aa1 Cdc16 Ube2c Anapc16 Ube2e1 Anapc7 Hist1h3d Anapc4 Anapc5 Anapc1 Anapc2 Ehmt2 Hist1h2ak Hist1h2ag Ehmt1 Hist1h2ah REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION%REACTOME DATABASE ID RELEASE 59%211733 Regulation of activated PAK-2p34 by proteasome mediated degradation Psmc6 Psmc5 Psmc2 Psmd2 Psmd12 Psma7 Psmd11 Psmb9 Psmf1 Psmb8 Psma5 Psme4 Psmd14 Psmb5 Psmb4 Ubc Psmd13 Psma4 Psmd10 Psmb7 Psma3 Psma6 Psmb6 Psmb2 Psmc1 Psmb3 Psmc4 Psmb1 Psma2 Psmc3 Psma1 Psme3 Psmd9 Psmd1 Shfm1 Psme2 Pak2 Psme1 Psmd3 Psmd4 Psmb10 Psmd6 Psmd5 Psmd7 Psmb11 Psmd8 OVARIAN TUMOR DOMAIN PROTEASES%REACTOME%R-HSA-5689896.3 Ovarian tumor domain proteases Rnf135 Esr1 Otud7a Apc Ripk1 Vcp Tnfaip3 Otud3 Trim25 Mavs Traf3 Ubc Otud7b Ifih1 Rnf128 Rhoa Tnip2 Nod2 Nod1 Zranb1 Ube2d1 Trp53 Traf6 Ripk2 Yod1 Ikbkg Tnip1 Pten Otub2 Ddx58 Otub1 Otud5 Tnip3 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES%REACTOME DATABASE ID RELEASE 59%425397 Transport of vitamins, nucleosides, and related molecules Alb Slc16a2 Slc5a6 Slc33a1 Slco2a1 Slco2b1 Slco4c1 Slco1c1 Slco1a4 Slco1b2 Slc35d1 Pdzd11 Slco4a1 Apod Slc35b4 Slc28a3 Lcn9 Slc35a1 Slc35a3 Slc28a1 Slc27a1 Slc27a6 Lcn12 Slc27a4 Slc29a1 Slc35b2 Slc35c1 Avp Slc28a2 Slc29a4 Slc29a2 Slc35a2 Slc29a3 Slc35d2 Slc35b3 POLO-LIKE KINASE MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 59%156711 Polo-like kinase mediated events Cenpf Wee1 Ccnb2 Cdc25c Pkmyt1 Plk1 Lin9 Mybl2 Lin37 Lin54 Ep300 Rbbp4 Cdc25a Foxm1 Lin52 ABNORMAL CONVERSION OF 2-OXOGLUTARATE TO 2-HYDROXYGLUTARATE%REACTOME%R-HSA-2978092.1 Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate Idh1 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 59%72203 Processing of Capped Intron-Containing Pre-mRNA Cwc22 Cwc27 Cwc25 Hnrnpd Nup85 Hnrnpc Nup160 Gcfc2 Prpf4 Prpf3 Wbp4 Usp39 Hnrnpu Hnrnpr Hnrnpa2b1 Hnrnpl Hnrnpm Hnrnpf Zcrb1 Dhx9 Hnrnpk Dhx16 Dhx15 Rnpc3 Plrg1 Prpf8 Gpkow Prpf6 Nup107 Smndc1 Srsf10 Hspa8 Nup37 Prpf31 Nup43 Nup133 Snrnp200 Prpf19 Wbp11 Zrsr2 Ctnnbl1 Hnrnpul1 Snrpb Sf1 Snrpd3 Txnl4a Slbp Hnrnph1 Hnrnph2 U2surp Eftud2 Ranbp2 Ddx5 Mettl14 Phf5a Sugp1 Puf60 Rbm22 Tra2b Ddx46 Nup50 Rbm17 Tpr Hnrnpa3 Ndc1 Nup214 Aaas Ddx42 Nup210 Nup188 Nup54 Nup35 Nupl2 Nup62 Nup205 Nup155 Nup88 Pom121 Rae1 Dnajc8 Nup93 Nup153 Isy1 Prpf38a Ddx23 Hnrnpa1 Hnrnpa0 Sf3b4 Sf3b3 Sf3b2 Pqbp1 Sf3b6 Sf3b5 Crnkl1 Bcas2 Sf3a1 Sf3a2 Sf3b1 Sf3a3 Snrnp70 Ybx1 Tfip11 Snrnp27 Cherp Snrnp25 Snrnp35 Elavl2 Skiv2l2 Elavl1 Pcbp1 Pcbp2 Cd2bp2 Snrnp48 Snrnp40 Fus Cwc15 Ppie Ppih Ppwd1 Prpf40a Ppil1 Polr2i Polr2j Prcc Polr2c Polr2d Nxt1 Polr2b Polr2g Srrt Snrpn Srrm2 Snrpc Snrpa Polr2a Xab2 Gtf2f1 Snrpa1 Ncbp1 Ncbp2 Gtf2f2 Lsm2 Lsm5 Ccar1 Lsm7 Lsm3 Lsm4 Mettl3 Lsm8 Nxf7 Lsm6 Ptbp1 Nxf1 Rbm5 Snrpb2 Snrpd2 Snrpd1 Sart1 Cdc5l Syf2 Pdcd7 Rbmx Aqr Zmat5 Eif4e Polr2f Polr2e Pabpn1 Polr2h Srsf2 Thoc7 Thoc6 Srsf3 Polr2k Slu7 Srsf11 Zc3h11a Magoh Cpsf1 Cstf1 Dhx38 Clp1 Thoc3 Srsf7 Thoc2 Thoc5 Thoc1 Srsf9 Alyref Srsf6 Nudt21 Cstf2t Fip1l1 Rbm8a Cstf3 Casc3 Sympk Eif4a3 U2af1l4 Chtop Srsf1 Cstf2 Cpsf3 Cpsf2 Cpsf4 Cpsf7 Ddx39b Upf3b Ddx39 Papola Fyttd1 Wdr33 Rnps1 Poldip3 Magohb Cdc40 Srrm1 GRB2 EVENTS IN ERBB2 SIGNALING%REACTOME DATABASE ID RELEASE 59%1963640 GRB2 events in ERBB2 signaling Egf Nrg2 Ereg Kras Nrg1 Nras Hras Sos1 Egfr Nrg3 Nrg4 Hbegf Erbb2 Btc REUPTAKE OF GABA%REACTOME DATABASE ID RELEASE 59%888593 Reuptake of GABA Slc6a11 Slc6a13 Slc6a12 Slc6a1 DNA METHYLATION%REACTOME DATABASE ID RELEASE 59%5334118 DNA methylation Hist1h2bg Hist1h2bh Dnmt3l Dnmt3b Hist1h2bp Hist1h2bm Hist1h2bj Hist1h2bb Hist2h3c1 H2afz H2afx H2afj H2afb2 Dnmt1 Hist2h2aa1 Hist1h3d Hist1h2ak Hist3h2ba Hist2h2be Uhrf1 Hist1h2ag Dnmt3a Hist2h2ac H3f3b Hist1h2ah H3f3a ION INFLUX EFFLUX AT HOST-PATHOGEN INTERFACE%REACTOME%R-HSA-6803544.1 Ion influx efflux at host-pathogen interface Slc11a1 Pdzd11 Atox1 Atp7a ONCOGENE INDUCED SENESCENCE%REACTOME DATABASE ID RELEASE 59%2559585 Oncogene Induced Senescence Erf Id1 Sp1 Cdkn2c Mdm4 Ubc E2f1 Cdkn2a Ets2 Ets1 Cdkn2b Tfdp2 Cdk4 Mapk3 Tfdp1 Mapk1 Cdk6 Ago1 E2f2 Tnrc6c Trp53 Tnrc6b E2f3 Tnrc6a Ago4 Ago3 Mdm2 Mov10 CLEARANCE OF NUCLEAR ENVELOPE MEMBRANES FROM CHROMATIN%REACTOME DATABASE ID RELEASE 59%2993913 Clearance of Nuclear Envelope Membranes from Chromatin Emd Banf1 Vrk1 Lemd3 Lemd2 ACTIVATION OF DNA FRAGMENTATION FACTOR%REACTOME%R-HSA-211227.1 Activation of DNA fragmentation factor Casp3 Hist1h1c Hist1h1e Hist1h1b Hist1h1a Kpnb1 Hist1h1d Hmgb2 H1f0 Dffb Dffa Kpna1 RESOLUTION OF ABASIC SITES (AP SITES)%REACTOME DATABASE ID RELEASE 59%73933 Resolution of Abasic Sites (AP sites) Parg Apex1 Lig3 Pcna Rfc5 Parp1 Rfc3 Rfc2 Rfc4 Rfc1 Nthl1 Ogg1 Neil1 Pole Pold1 Parp2 Pold2 Mpg Xrcc1 Pold3 Pold4 Mbd4 Neil2 Smug1 Polb Pole2 Rpa2 Rpa1 Rpa3 Pnkp Lig1 Fen1 Pole4 Mutyh Pole3 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 59%1660499 Synthesis of PIPs at the plasma membrane Pip5k1a Pi4k2b Bmx Rab5a Pik3c2b Pik3c2a Mtm1 Pik3c2g Mtmr1 Mtmr3 Mtmr6 Inppl1 Inpp4b Inpp4a Pik3r6 Arf1 Inpp5k Pik3r5 Pik3cb Pik3cd Pip5k1b Pip5k1c Rab14 Pip4k2b Rab4a Pip4k2a Pip4k2c Inpp5d Pi4k2a Pik3ca Plekha5 Plekha6 Rufy1 Plekha8 Pten Synj2 Pik3cg Ptpn13 Plekha1 Plekha2 Pik3r3 Pik3r1 Ocrl Synj1 Mtmr14 Pik3r2 Plekha3 S PHASE%REACTOME%R-HSA-69242.2 S Phase Rb1 Rfc5 Mcm6 Ccne1 Gins1 Rfc3 Mcm3 Mcm2 Mcm5 Ccne2 Mcm4 Rfc2 Gins4 Rfc4 Esco2 Gins2 Esco1 Rfc1 Gins3 Ptk6 Orc4 Orc5 Mcm8 Mcm7 Pole Mnat1 Cdt1 Cdc45 Dna2 Pold1 Pold2 Pold3 Pold4 Orc2 Orc3 Orc6 Orc1 Stag2 Prim1 Pole2 Rpa2 Stag1 Rpa1 Rpa3 Pola1 Pola2 Smc1a Lig1 Rad21 Fen1 Pole4 Prim2 Pole3 Cdkn1a Wapal Psmd12 Psmd11 Psmd14 Psmd13 Psmd10 Cdca5 Smc3 Shfm1 Pds5a Pds5b Psmc6 Psmc5 Psmc2 Psmd2 Pcna Psmb9 Psmf1 Psmb8 Psme4 Cdc6 Cdk2 Skp1a Psmc1 Ccna1 Psmc4 Psmc3 Skp2 Cdc25a Ccna2 Cul1 Cdk4 Psme3 Cks1b Max Fzr1 Ccnd1 Cdc25b Cdkn1b Wee1 Psma7 Psma5 Psmb5 Psmb4 Ubc Psma4 Psma3 Psmb7 Myc Psma6 Psmb6 Psmb2 Psmb3 Psma2 Psmb1 Psma1 Psmd9 Psmd1 Psme2 Psme1 Psmd3 Psmd4 Ccnh Psmb10 Psmd6 Psmd5 Cdk7 Psmd7 Psmb11 Psmd8 NEGATIVE REGULATION OF FGFR2 SIGNALING%REACTOME%R-HSA-5654727.1 Negative regulation of FGFR2 signaling Ppp2cb Spry2 Fgf23 Fgf22 Ppp2ca Fgf20 Frs2 Ppp2r1a Mknk1 Fgf1 Ubc Cbl Fgf2 Fgf9 Fgf7 Mapk3 Fgf6 Fgf4 Mapk1 Fgf3 Fgf16 Fgf18 Braf Fgf10 Ptpn11 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF UNSATURATED FATTY ACIDS%REACTOME%R-HSA-77288.2 mitochondrial fatty acid beta-oxidation of unsaturated fatty acids Acadl Hadhb Acadm Hadha Eci1 Decr1 AXIN MISSENSE MUTANTS DESTABILIZE THE DESTRUCTION COMPLEX%REACTOME%R-HSA-5467340.1 AXIN missense mutants destabilize the destruction complex Ppp2r1b Ppp2cb Apc Axin1 Ppp2ca Amer1 Csnk1a1 Gsk3b Ppp2r1a Ppp2r5b Ppp2r5e Ppp2r5c Ppp2r5d Ppp2r5a INTERFERON ALPHA BETA SIGNALING%REACTOME DATABASE ID RELEASE 59%909733 Interferon alpha beta signaling Irf8 H2-M3 Ptpn1 Irf7 H2-M5 Irf6 Irf1 Irf4 2010002M12Rik Jak1 H2-Q1 Rnasel Ifit2 Gbp2 Isg15 Psmb8 Irf2 Irf3 Tyk2 Ip6k2 Socs3 Ifitm2 Samhd1 Ifitm3 Socs1 Oasl1 Oas1g Ifi35 Ifnb1 Ifna16 Irf9 Ifi27 Irf5 Usp18 Ifnar1 Stat2 Rsad2 Oas2 Oas3 Bst2 Adar H2-Q10 Ptpn6 Egr1 Ptpn11 Isg20 Ifit3b IRS-MEDIATED SIGNALLING%REACTOME%R-HSA-112399.2 IRS-mediated signalling Pik3c3 Prkaa2 Akap9 Ppp2r1a Pik3r4 Prkaa1 Csf2 Jak1 Tsc1 Prkag2 Prkag1 Prkag3 Frs2 Nras Frs3 Rasgrf1 Psmf1 Raf1 Psme4 Il5ra Fgf1 Il17rd Fgf2 Cnksr1 Csk Cnksr2 Erbb2 Fgf9 Ptk2 Fgf7 Psme3 Fgf6 Fgf4 Fgf3 Ppp5c Ranbp9 Lamtor1 Ppp2cb Shc1 Lamtor2 Ppm1a Nrg2 Tlr9 Ppp2ca Shc3 Lamtor5 Nrg1 Akt2 Shc2 Psma7 Artn Nrtn Lamtor4 Brap Psmb5 Psmb4 Ubc Nrg3 Psmb7 Nrg4 Psmb6 Psmb2 Psmb3 Psmb1 Prkab1 Mapk3 Akt1 Mapk1 Ksr1 Ptpra Dusp16 Dusp10 Stk11 Map3k11 Prkab2 Paqr3 Psme2 Psme1 Ncam1 Sos1 Braf Psmb10 Apbb1ip Psmb11 Csf2rb2 Rapgef2 Csf2ra Actn2 Nf1 Tsc2 Pdgfrb Pdgfra Mlst8 Kbtbd7 Il2rg Arrb2 Egfr Gab1 Arrb1 Mtor Ret Vwf Rptor Sptan1 Pspn Pde3b Map2k1 Rbx1 Fgg Map2k2 Cul3 Rragd Psmd12 Rragb Pdgfb Rragc Psmd11 Rraga Rasgef1a Eif4b Psmd14 Rasa3 Rasa4 Psmd13 Psmd10 Il2 Rasa2 Rasa1 Nefl Spred3 Kit Spred2 Grin2a Spred1 Spta1 Il5 Sptbn4 Ppp2r1b Ywhab Kras Gdnf Shfm1 Cab39 Eif4e Strada Irs2 Stradb Cab39l Syngap1 Eef2k Hbegf Eif4g1 Irs1 Eif4ebp1 Il3ra Btc Il2ra Il2rb Angpt1 Ptpn11 Trib3 Psmc6 Egf Fgf23 Psmc5 Fgf22 Mark3 Psmc2 Fgf20 Psmd2 Dab2ip Tek Psmb9 Psmb8 Araf Hras Grin1 Ppp2r5e Dlg4 Ppp2r5c Ppp2r5d Ppp2r5a Psmc1 Psmc4 Psmc3 Pik3cb Sptbn2 Sptbn1 Itgb3 Fyn Phb Grin2c Rasgrp4 Rasgrp3 Pebp1 Ppp2r5b Rasgrp1 Tln1 Pik3ca Fga Fgb Grin2d Grin2b Sptb Hgf Gfra2 Gfra3 Gfra4 Ereg Jak2 Pea15a Itga2b Rap1a Jak3 Wdr83 Camk2d Rap1b Camk2a Fgfr4 Camk2b Psma5 Rasal3 Rasal2 Psma4 Psma3 Psma6 Akt1s1 Vcl Camk2g Psma2 Psma1 Gfra1 Psmd9 Dusp7 Iqgap1 Fgf16 Dusp6 Dusp9 Fgf15 Dusp8 Klb Fgf18 Them4 Psmd1 Met Fn1 Rasal1 Dusp1 Psmd3 Psmd4 Pdpk1 Psmd6 Psmd5 Dusp2 Psmd7 Pik3r1 Dusp5 Psmd8 Fgf10 Pik3r2 Dusp4 SIGNALING BY FGFR4 IN DISEASE%REACTOME DATABASE ID RELEASE 59%5655291 Signaling by FGFR4 in disease Sos1 Gab1 Kras Frs2 Nras Pik3r1 Fgfr4 Plcg1 Hras Pik3ca NRAGE SIGNALS DEATH THROUGH JNK%REACTOME%R-HSA-193648.1 NRAGE signals death through JNK Akap13 Ect2 Vav1 Bad Rac1 Mapk8 Ngef Arhgef10l Sos2 Arhgef26 Fgd2 Net1 Fgd4 Fgd1 Fgd3 Trio Arhgef17 Arhgef10 Vav3 Gna13 Plekhg5 Arhgef19 Arhgef16 Arhgef15 Abr Arhgef18 Plekhg2 Arhgef40 Arhgef38 Arhgef39 Mcf2 Mcf2l Arhgef37 Tiam2 Tiam1 Ngf Arhgef7 Arhgef11 Aatf Arhgef12 Arhgef3 Kalrn Arhgef4 Arhgef1 Vav2 Arhgef2 Bcl2l11 Sos1 Arhgef9 Prex1 Arhgef6 Itsn1 Maged1 Ngfr CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKK%REACTOME%R-HSA-442717.1 CREB phosphorylation through the activation of CaMKK Creb1 Camkk1 Camk4 FERTILIZATION%REACTOME DATABASE ID RELEASE 59%1187000 Fertilization Izumo4 Zp3 Izumo2 Kcnu1 Izumo1 Hvcn1 Catsperg1 Catsperd Catsper1 Catsper2 Catsper3 Catsperb Catsper4 Hyal5 Acr B4galt1 Adam2 Ovgp1 Cd9 Adam30 Adam21 Zp1 Zp2 TNFR1-INDUCED NFKAPPAB SIGNALING PATHWAY%REACTOME%R-HSA-5357956.1 TNFR1-induced NFkappaB signaling pathway Tnf Tradd Chuk Ripk1 Tnfaip3 Usp21 Xiap Otud7b Usp2 Usp4 Traf1 Cyld Traf2 Sharpin Map3k7 Gnb2l1 Birc3 Birc2 Tab1 Tab2 Tab3 Ikbkb Rbck1 Ikbkg Rnf31 Tnfrsf1a NEGATIVE REGULATION OF TCF-DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS%REACTOME DATABASE ID RELEASE 59%3772470 Negative regulation of TCF-dependent signaling by WNT ligand antagonists Sost Dkk1 Wnt4 Wnt9a Dkk2 Wnt3a Kremen2 Wif1 Kremen1 Dkk4 Lrp6 Wnt5a Lrp5 Sfrp2 Sfrp1 ANTIGEN PROCESSING-CROSS PRESENTATION%REACTOME%R-HSA-1236975.1 Antigen processing-Cross presentation Psmc6 Psmc5 Psmc2 Psmd2 Psmb9 Psmf1 Psmb8 Psme4 Ncf4 Ncf2 Ncf1 Psmc1 Myd88 Psmc4 Psmc3 Psme3 Cd207 Cybb Cyba Fcgr1 Sec22b H2-M3 Mrc2 H2-M5 Mrc1 Vamp8 Chuk Sec61a2 Vamp3 H2-Q1 Stx4a Calr Tapbp Psmd12 Tlr2 Btk Psma7 Tlr6 Psmd11 Sec61g Sec61a1 Sec61b Pdia3 Psmd14 Psma5 Psmb5 Psmb4 Ubc Psmd13 Psmd10 Psma4 Psmb7 Psma3 Psma6 Psmb6 Psmb2 Itgav Psmb3 Psmb1 Psma2 Psma1 Lnpep Psmd9 Ctss Ikbkb Tlr4 Ctsl Psmd1 Shfm1 Ly96 Psme2 Cd14 Psme1 Ikbkg Psmd3 Itgb5 Cd36 Psmd4 Psmb10 Snap23 Tap1 Psmd6 H2-Q10 Tap2 Psmd5 Tlr1 Tirap Psmd7 Psmb11 Psmd8 B2m THE PHOTOTRANSDUCTION CASCADE%REACTOME DATABASE ID RELEASE 59%2514856 The phototransduction cascade Grk1 Gngt1 Pde6g Camkmt Prkca Slc24a1 Prkcq Nmt2 Rho Nmt1 Fnta Gnat1 Pde6a Gucy2e Rcvrn Gnb1 Pde6b Gucy2f Cnga1 Rgs9bp Fntb Guca1a Sag Guca1b Ppef1 Metap2 Metap1 DEFECTIVE B4GALT1 CAUSES B4GALT1-CDG (CDG-2D)%REACTOME%R-HSA-3656244.1 Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Omd Prelp Kera Lum Ogn Fmod SYNTHESIS AND PROCESSING OF GAG, GAGPOL POLYPROTEINS%REACTOME%R-HSA-174495.1 Synthesis And Processing Of GAG, GAGPOL Polyproteins Ubc Vps37d Tsg101 Vps37c Vps37b Nmt2 Vps37a Tonsl ASYMMETRIC LOCALIZATION OF PCP PROTEINS%REACTOME%R-HSA-4608870.1 Asymmetric localization of PCP proteins Psmc6 Scrib Vangl2 Psmc5 Psmc2 Psmd2 Psmb9 Psmb8 Psmf1 Dvl2 Psme4 Psmc1 Psmc4 Psmc3 Psme3 Prickle1 Pard6a Wnt5a Psmd12 Psma7 Psmd11 Psmd14 Psma5 Psmb5 Psmb4 Psmd13 Ubc Psmd10 Psma4 Psmb7 Psma3 Psma6 Psmb6 Psmb2 Psmb3 Psmb1 Psma2 Psma1 Psmd9 Smurf1 Psmd1 Shfm1 Psme2 Psme1 Psmd3 Psmd4 Psmb10 Psmd6 Fzd2 Psmd5 Fzd1 Fzd3 Psmd7 Fzd4 Smurf2 Fzd5 Fzd7 Fzd8 Psmb11 Psmd8 NEF MEDIATED DOWNREGULATION OF CD28 CELL SURFACE EXPRESSION%REACTOME%R-HSA-164939.1 Nef mediated downregulation of CD28 cell surface expression Ap2m1 OXIDATIVE DEMETHYLATION OF DNA%REACTOME%R-HSA-5221030.1 Oxidative demethylation of DNA Tet3 Tet2 Tet1 CIRCADIAN CLOCK%REACTOME%R-HSA-400253.1 Circadian Clock Serpine1 Helz2 Btrc Chd9 Skp1a Arntl Clock Nr3c1 Cul1 Mef2c Hif1a Ppp1cc Creb1 Sirt1 Rora Ncor1 Nampt Csnk1d Ccrn4l Crtc1 Mef2d Cry1 Csnk1e Bhlhe41 Dbp Cry2 Atf2 Nrip1 Crebbp Arntl2 Sik1 Bhlhe40 Rai1 Rbm4 Per2 Per1 Srebf1 Ep300 Nfil3 Cpt1a Smarcd3 Klf15 Crtc3 Crtc2 Med1 Nr1d1 Ppara Tbl1x Ubc Ppp1cb Ppargc1a Rxra Carm1 Ppp1ca Avp Ncoa1 Npas2 Fbxl3 Ncoa6 F7 Ncoa2 Tbl1xr1 Hdac3 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%R-HSA-176409.2 APC C:Cdc20 mediated degradation of mitotic proteins Psmc6 Psmc5 Nek2 Psmc2 Psmd2 Psmb9 Psmf1 Psmb8 Psme4 Cdk1 Psmc1 Ccna1 Psmc4 Psmc3 Ccna2 Anapc15 Psme3 Anapc11 Anapc10 Pttg1 Bub1b Psmd12 Psma7 Psmd11 Psmd14 Psma5 Psmb5 Psmb4 Ubc Psmd13 Bub3 Psmd10 Psma4 Psmb7 Psma3 Psma6 Psmb6 Psmb2 Mad2l1 Psmb3 Psmb1 Psma2 Psma1 Cdc23 Psmd9 Ube2d1 Cdc27 Cdc16 Cdc20 Ube2c Anapc16 Ube2e1 Anapc7 Psmd1 Shfm1 Psme2 Anapc4 Anapc5 Psme1 Anapc1 Anapc2 Psmd3 Psmd4 Psmb10 Psmd6 Psmd5 Psmd7 Psmb11 Psmd8 NEUROTRANSMITTER CLEARANCE IN THE SYNAPTIC CLEFT%REACTOME%R-HSA-112311.2 Neurotransmitter Clearance In The Synaptic Cleft Aldh2 Slc6a4 Bche Ache Slc22a2 Slc22a1 Comt Slc6a3 Maoa VEGF LIGAND-RECEPTOR INTERACTIONS%REACTOME%R-HSA-194313.1 VEGF ligand-receptor interactions Vegfa Vegfb Vegfc Figf Kdr Flt4 Pgf Flt1 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME DATABASE ID RELEASE 59%2979096 NOTCH2 Activation and Transmission of Signal to the Nucleus Adam10 Psen2 Ncstn Mdk Notch2 Mib2 Neurl1a Ubc Neurl1b Cntn1 Jag2 Mib1 Dll1 Aph1b Dll4 Jag1 DISEASE%REACTOME%R-HSA-1643685.3 Disease Agrn Xrcc5 Xrcc6 Hdac4 Lum Hdac5 Rngtt Rnmt Adamts13 Adamts14 Adamts15 Thsd7a Mib2 Hdac10 Neurl1a Neurl1b Hey1 Hdac11 Hey2 Hspa1a Hdac7 Hdac6 Hdac9 Lig1 Hdac8 Fen1 Hes5 Thsd7b Lmna Mib1 Heyl Hes1 Ap2m1 Ap2a1 Ap2a2 Sh3gl2 Ap2s1 Ctbp1 Porcn Ctbp2 Dkk1 Tnks Fzd6 Pcx Dkk2 Gys2 Clta Ap2b1 Wnt3a Tnks2 Kremen2 Cltc Kremen1 Dkk4 Fzd4 Fzd5 Fzd8 Lrp6 Tcf7l2 Lrp5 Sema5b Rnf43 Gck Nup50 Agtrap Tpr Qk Clcn6 Fam131b Ndc1 Ap3b1 Nup214 Snd1 Sod2 Aaas Aggf1 Trak1 Nup210 Capn1 Notch1 Cast Kdm7a Skp1a Nup188 Nup54 Csk Capns1 Fxr1 Nup35 D630045J12Rik Capn2 Nupl2 Mprip Nup62 Capns2 Nup205 Cul1 Nup155 Nup88 Fam114a2 Papd7 Pom121 Agk Zc3hav1 Rae1 Nup93 Cdc25b Nup153 Opn1sw Omd Mc2r Prelp Kera Ogn Ttf1 Ran Adam10 Napepld Cd8b1 Bcr Fgfr1 Myo18a Rlbp1 Trim24 Fgfr3 Stra6 Bag4 Cux1 Snap25 Erlin2 Cul5 Fgfr1op2 Gab2 Cpsf6 Zmym2 Kpnb1 Mmachc Gif Kpna1 Amn Ap1s2 Ap1b1 Mut Mtrr Ap1s1 Ap1g1 Cd320 Tgfbr1 Cubn Pacs1 Mmadhc H2-Q10 Fkbp1a Mmaa Tgfbr2 Tcn2 Ap1s3 Syt1 Adam17 Vamp2 Mtr B2m Jag2 Dll1 Dll4 Ap1m2 Erlec1 Stx1a Ap1m1 Jag1 Casp9 Nf1 Tsc2 Pdgfrb Stat5b Pdgfra Stat5a Mlst8 Vav1 Arrb2 Egfr Traf3 Gab1 Arrb1 Mtor Hdac1 Vwf Stx1b Maml2 Aph1b Polr2i Maml1 Polr2j Nelfa Nelfb Mnat1 Polr2c Polr2d Supt4a Polr2b Spon2 Slc25a4 Polr2g Spon1 Ctdp1 Polr2a Nelfe Supt5 Nelfcd Kat2b Ihh Gtf2f1 Kat2a Ncbp1 Shh Dhh Ncbp2 Gtf2f2 Thsd4 Map2k1 Apc Bgn Rbx1 Dcn Axin1 Ltf Fgg Amer1 Thsd1 Bcan Cdkn1a Csnk1a1 Map2k2 Ctnnb1 Psmd12 Pdgfb Psmd11 Sspo Cspg4 Cspg5 Psmd14 Ercc3 Rasa3 Rasa4 Psmd13 Psmd10 Rasa2 Rasa1 Pomc Kit Cfp Ncan Vcan Ercc2 Ppp2r1b Ywhab Notch4 Ccdc59 Kras Gsk3a Gsk3b Shfm1 Notch3 Gucy2c Notch2 Trat1 Irs2 Mdm2 Syngap1 Avp Lck Avpr1a Hbegf Avpr2 Cd4 Avpr1b Irs1 Btc Gys1 Gyg Ptpn11 Tbl1xr1 Psmc6 Egf Fgf23 Psmc5 Ppp1r3c Fgf22 Mark3 Psmc2 Canx Fgf20 Prdx2 Psmd2 Dab2ip Prdx1 Ccnc Psmb9 Psmb8 Hsp90aa1 Araf Hras Ppp2r5e Mapkap1 Ppp2r5c Rps6kb2 Ppp2r5d Ppp2r5a Psmc1 Psmc4 Psmc3 Pik3cb Epm2a Foxo3 Pik3cd Foxo1 Itgb3 Fyn Hck Creb1 Phb Ell Stat1 Taf9b Pebp1 Ppp2r5b Sh3kbp1 Tln1 Pik3ca Adamts3 Crebbp Idh1 Adamts6 Cdkn1b Adamts7 Fga Adamts2 Fgb Thbs1 Nr4a1 Fgfr1op Rbpj Prr5 Slc25a5 Hgf Thbs2 Papss1 Adamts12 Alb Ereg Adamts19 Cdc25c Jak2 Adamts10 Itga2b Rap1a Maml3 Btk Cftr Rap1b Fgfr4 Psma5 Rasal3 Rasal2 Psma4 Psma3 Adamts20 Psma6 Akt1s1 Vcl Psma2 Psma1 Cd9 Cd19 Dnajc3 Psmd9 Adamtsl3 Adamtsl4 Iqgap1 Adamtsl1 Adamtsl2 Fgf16 Tgfb1 Fgf15 Ak6 Klb Psen2 Fgf18 Dag1 Ncstn Psmd1 Fmod Met Adamts5 Fn1 Bcl2l11 Adamtsl5 Rasal1 Psmd3 Psmd4 Ccnh Pdpk1 Psmd6 Ccnk Psmd5 Mamld1 Pik3r3 Psmd7 Pik3r1 Psmd8 Fgf10 Pik3r2 Hdac3 Nup85 Nup160 Vcp Akap9 Cdk9 Rps27 Ppp2r1a Isg15 Cdk8 Ywhae Xpo1 Btrc Taf1 Nfkb2 Taf2 Nfkb1 Myd88 Taf4b Taf7 Taf4a Taf5 Taf6 Taf3 Tlr5 Hdac2 App Sbspon Rac1 Src Jun Smad4 Npm1 Map2k7 Smad2 Map2k4 Taf9 Smad3 Rela Ccnt1 Psip1 Nfkbia Nedd4l Nfkbib Banf1 Irak4 Nup107 Ep300 Ccnt2 Txnrd1 Cd86 Taf13 Taf11 Tbl1x Atg7 Nup37 Calr Nup43 Tlr2 Nup133 Tlr6 Cd80 Stat3 Ccr5 Taf12 Cxcr4 Adamts4 Adamts1 Adamts8 Atp6v1h Ipo5 Grsf1 Cd36 Adamts18 Ranbp2 Adamts16 Tlr1 Tirap Kpna3 Kpna4 Kpna7 Lig4 Frs2 Nras Psmf1 Raf1 Psme4 Fgf1 Bad Fgf2 Cnksr1 Cnksr2 Erbb2 Fgf9 Cdc25a Fgf7 Sv2a Psme3 Fgf6 Fgf4 Fgf3 Fdx1 Fdx1l Sv2c Ncor1 Vamp1 Sv2b Ncor2 Cyp11a1 Fdxr Furin Ssrp1 Syt2 Gtf2h1 Fgfr2 Gtf2h2 Ppp2cb Gtf2h5 Shc1 Chuk Gtf2h4 Nrg2 Ppp2ca Nrg1 Akt2 Akt3 Psma7 Plcg1 Gtf2h3 Brap Psmb5 Psmb4 Ubc Nrg3 Psmb7 Myc Nrg4 Psmb6 Psmb2 Psmb3 Psmb1 Mapk3 Akt1 Mapk1 Ksr1 Ppia Map3k11 Tcea1 Tceb1 Pik3ap1 Tceb3 Psme2 Sftpd Supt16 Psme1 Kcnj11 Sos1 Rictor Abcc8 Braf Psmb10 Apbb1ip Xrcc4 Cdk7 Psmb11 Csf2rb2 Eif2ak2 Csf2ra Mccc2 Gtf2a1 Mccc1 Gtf2a2 Os9 Lmnb1 Gtf2b Rnf185 Derl2 Hmga1 Rnf5 Syvn1 Sel1l Elmo1 Gtf2e1 Gtf2e2 Eef2 Sh3gl1 Stam Hgs Stam2 Eps15 Chmp5 Chmp7 Chmp6 Chmp3 Vps37d Fasl Cbll1 Rcc1 Vps37c Pdzd3 Vps37b Pdcd6ip Tonsl Vps4b Vps4a Vta1 Chmp2a Chmp4c Ttr Chmp4b Cbl Pcca Acaca Nmt2 Vps37a Ranbp1 Pccb Nmt1 Cdk5r1 Rbp1 Ticam1 Ikbkb Sema5a Rbp4 Opn1mw Tlr4 Tlr3 Ly96 Dock2 Cd14 Pak2 Ikbkg Tsg101 Hsp90ab1 Cdk5 Rpl39 Rplp1 Rpl7 Rps21 Rplp2 Cdc37 Rps25 Rpl4 Rps26 Rps27l Rpl18a Rpl34 Golga2 Rpl32 Arf1 Rpl26 Rpl24 Rps9 Rps7 Rps5 Polr2f Polr2e Pabpn1 Polr2h Tbp Polr2k Rpsa Muc1 Rpl37 Muc4 Rps4x Muc15 Ctnnd1 Cdh1 Muc20 Muc13 Cpsf4 Sdc3 Sdc4 Rpl22 Gpc6 Sdc2 Rpl10l Gpc3 Rpl23 Sdc1 Rpl39l Gpc5 Gpc2 Rpl13a Erlin1 Rpl22l1 Gckr Gpc4 Rps15a Sftpb Rpl11 Sftpc Rpl17 Sftpa1 Rps3 Rpl19 Derl1 Rpl18 Derl3 Rps16 Rps14 Rps19 Rps18 Rps11 Rps10 Hspg2 Gpc1 SIGNAL ATTENUATION%REACTOME%R-HSA-74749.2 Signal attenuation Grb10 Sos1 Shc1 Irs2 Ins2 Insr Irs1 Mapk3 Mapk1 THE PROTON BUFFERING MODEL%REACTOME DATABASE ID RELEASE 59%167827 The proton buffering model Slc25a27 Slc25a14 Ucp1 Ucp3 Ucp2 SUMOYLATION OF CHROMATIN ORGANIZATION PROTEINS%REACTOME DATABASE ID RELEASE 59%4551638 SUMOylation of chromatin organization proteins Pias1 L3mbtl2 Ube2i GLUCONEOGENESIS%REACTOME%R-HSA-70263.1 Gluconeogenesis Gapdhs Eno1b Slc25a10 Slc25a12 Prkacb Pck2 Got1 Slc25a13 Slc25a11 Mdh1 Slc25a1 Aldoc Aldob Aldoa Pcx Eno2 Pck1 Eno3 Tpi1 Pgk2 Eno1 Pgk1 Mdh2 Fbp1 Fbp2 Gpi1 Prkaca Pgam1 Pgam2 Got2 Pfkfb1 THROMBOXANE SIGNALLING THROUGH TP RECEPTOR%REACTOME%R-HSA-428930.1 Thromboxane signalling through TP receptor Gngt1 Gng7 Tbxa2r Gng4 Gngt2 Gng10 Gng11 Gng13 Gng12 Gnb2 Gnb1 Gnb3 Gnb5 Gnb4 Gna11 Gng8 Gnaq Gna15 Gng3 Gna13 Gng2 Gna14 SIGNALING BY HIGH-KINASE ACTIVITY BRAF MUTANTS%REACTOME DATABASE ID RELEASE 59%6802948 Signaling by high-kinase activity BRAF mutants Map2k1 Mark3 Fgg Itga2b Map2k2 Rap1a Nras Rap1b Araf Hras Raf1 Arrb2 Arrb1 Cnksr1 Csk Cnksr2 Vcl Vwf Mapk3 Mapk1 Itgb3 Ksr1 Ywhab Iqgap1 Kras Pebp1 Fn1 Tln1 Braf Apbb1ip Fga Fgb AMINE-DERIVED HORMONES%REACTOME%R-HSA-209776.1 Amine-derived hormones Tpo Slc5a5 Tph2 Duox2 Ddc Th Dio3 Dbh Iyd Tph1 Pnmt Dio2 Cga Aanat Duox1 Dio1 Tshb MTOR SIGNALLING%REACTOME%R-HSA-165159.3 mTOR signalling Prkag2 Prkag1 Prkag3 Ppm1a Lamtor2 Prkaa2 Lamtor5 Tsc2 Akt2 Rragd Rragb Rragc Rraga Tsc1 Eif4b Mlst8 Lamtor4 Mtor Akt1s1 Prkaa1 Prkab1 Akt1 Ywhab Stk11 Rptor Prkab2 Cab39 Eif4e Strada Stradb Cab39l Eef2k Eif4g1 Eif4ebp1 Lamtor1 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES%REACTOME DATABASE ID RELEASE 59%1169410 Antiviral mechanism by IFN-stimulated genes Nup85 Ppm1b Nup160 Nup50 Isg15 Tpr Ube2l6 Trim25 Irf3 Ndc1 Nup214 Aaas Nup210 Nup188 Nup54 Pin1 Nup35 Nupl2 Nup62 Flnb Nup205 Nup155 Nup88 Pom121 Rae1 Nup93 Stat1 Nup153 Arih1 Uba7 Nup107 2010002M12Rik Jak1 Eif4a3 Nup37 Nup43 Nup133 Plcg1 Ubc Nedd4 Mapk3 Eif4a1 Eif4a2 Usp18 Ube2e1 Kpnb1 Ube2n Kpna1 Eif4e Ranbp2 Eif4g1 Eif4g2 Kpna3 Kpna4 Eif4e3 Eif4g3 Kpna7 Ddx58 Eif2ak2 IKBKG DEFICIENCY CAUSES ANHIDROTIC ECTODERMAL DYSPLASIA WITH IMMUNODEFICIENCY (EDA-ID) (VIA TLR)%REACTOME DATABASE ID RELEASE 59%5603027 IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) Nfkbia Nfkb2 Chuk Nfkb1 Nfkbib Ikbkb Ikbkg Rela G1 S DNA DAMAGE CHECKPOINTS%REACTOME DATABASE ID RELEASE 59%69615 G1 S DNA Damage Checkpoints Psmc6 Psmc5 Psmc2 Psmd2 Psmb9 Psmb8 Psmf1 Psme4 Ccne1 Mdm4 Cdk2 Ccne2 Psmc1 Ccna1 Psmc4 Psmc3 Cdc25a Ccna2 Psme3 Chek2 Atm Cdkn1b Chek1 Cdkn1a Psmd12 Psma7 Psmd11 Psmd14 Psma5 Psmb5 Psmb4 Ubc Psmd13 Psmd10 Psma4 Psmb7 Psma3 Pcbp4 Psma6 Psmb6 Psmb2 Psmb3 Psmb1 Psma2 Psma1 Zfp385a Psmd9 Trp53 Psmd1 Shfm1 Psme2 Psme1 Rfwd2 Psmd3 Psmd4 Mdm2 Psmb10 Psmd6 Psmd5 Psmd7 Psmb11 Psmd8 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA%REACTOME%R-HSA-212718.1 EGFR interacts with phospholipase C-gamma Adcy7 Egf Adcy6 Prkcd Adcy5 Prkce Adcy4 Adcy3 Adcy2 Prkar2a Prkcg Adcy1 Prkacb Adcy9 Plcg1 Adcy8 Prkca Prkar2b Egfr Adrbk1 Creb1 Pde1c Camk4 Pde1b Pde1a Itpr1 Prkar1a Prkar1b Ahcyl1 Prkaca Itpr3 Itpr2 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM%REACTOME DATABASE ID RELEASE 59%2046104 alpha-linolenic (omega3) and linoleic (omega6) acid metabolism Abcd1 Fads1 Acaa1a Elovl1 Elovl5 Hsd17b4 Elovl3 Elovl2 Acot8 Fads2 Scp2 Acsl1 DNA STRAND ELONGATION%REACTOME%R-HSA-69190.2 DNA strand elongation Pcna Rfc5 Mcm6 Gins1 Rfc3 Mcm3 Mcm2 Mcm5 Mcm4 Rfc2 Gins4 Rfc4 Gins2 Rfc1 Gins3 Mcm8 Mcm7 Cdc45 Dna2 Pold1 Pold2 Pold3 Pold4 Prim1 Rpa2 Rpa1 Rpa3 Pola1 Pola2 Lig1 Fen1 Prim2 FGFR2B LIGAND BINDING AND ACTIVATION%REACTOME%R-HSA-190377.2 FGFR2b ligand binding and activation Fgf1 Fgf22 Fgf2 Fgfbp3 Fgf7 Fgf10 Fgfbp1 Fgf3 TIE2 SIGNALING%REACTOME%R-HSA-210993.1 Tie2 Signaling Grb7 Shc1 Angpt2 Kras Nras Tek Angpt4 Grb14 Dok2 Pik3ca Hras Sos1 Pik3r1 Pik3cb Ptpn11 Angpt1 Pik3r2 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 59%416993 Trafficking of GluR2-containing AMPA receptors Grip1 Gria2 Grip2 Prkcg Nsf Tspan7 Pick1 Gria3 Gria4 Ap2a1 Prkcb Prkca Gria1 SYNDECAN INTERACTIONS%REACTOME DATABASE ID RELEASE 59%3000170 Syndecan interactions Sdc3 Itga6 Sdc4 Itgb4 Itgb1 Sdc2 Tnc Tgfb1 Sdc1 Actn1 Prkca Itgb5 Vtn Cask Fgf2 Itgav Itga2 Thbs1 Itgb3 Trappc4 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES%REACTOME%R-HSA-380320.1 Recruitment of NuMA to mitotic centrosomes Tubg2 Numa1 Nedd1 Cdk1 Tubg1 Tubgcp2 Tubgcp5 Tubgcp4 Tubgcp3 TOXICITY OF TETANUS TOXIN (TENT)%REACTOME DATABASE ID RELEASE 59%5250982 Toxicity of tetanus toxin (TeNT) Vamp2 VXPX CARGO-TARGETING TO CILIUM%REACTOME%R-HSA-5620916.1 VxPx cargo-targeting to cilium Rab11a Exoc3 Exoc4 Exoc1 Exoc5 Exoc6 Rab3ip Exoc8 Exoc7 Exoc2 Rab8a Pkd1 Pkd2 Gbf1 Cnga4 Asap1 Rho Cnga2 Arf4 Rab11fip3 NEUROFASCIN INTERACTIONS%REACTOME DATABASE ID RELEASE 59%447043 Neurofascin interactions Cntn1 Ank1 Sdcbp Nrcam Cntnap1 Nfasc Dcx FUSION AND UNCOATING OF THE INFLUENZA VIRION%REACTOME DATABASE ID RELEASE 59%168270 Fusion and Uncoating of the Influenza Virion INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION%REACTOME%R-HSA-400508.1 Incretin synthesis, secretion, and inactivation Grp Isl1 Dpp4 Gcg Gnat3 Gata4 Gng13 Sec11c Sec11a Cdx2 Gnb3 Lep Ffar4 Gpr119 Pcsk1 Spcs1 Gip Tcf7l2 Spcs2 Ffar1 Spcs3 Pax6 ACTIVATION OF THE TFAP2 (AP-2) FAMILY OF TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 59%8866907 Activation of the TFAP2 (AP-2) family of transcription factors Tfap2b Cited1 Tfap2a Crebbp Cited2 Tfap2d Tfap2c Yeats4 Ep300 Wwox Tfap2e Cited4 FMO OXIDISES NUCLEOPHILES%REACTOME DATABASE ID RELEASE 59%217271 FMO oxidises nucleophiles Fmo1 Fmo2 Fmo3 SIGNALING BY HEDGEHOG%REACTOME%R-HSA-5358351.2 Signaling by Hedgehog Disp2 Vcp Os9 Derl2 Btrc Arrb2 Arrb1 Syvn1 Sel1l Adrbk1 Gas1 Gas8 Evc2 Boc Smo Evc Iqce Ptch1 Ihh Shh Dhh Notum Rbx1 Csnk1a1 Cul3 Psmd12 Psmd11 Kif3a Psmd14 Psmd13 Psmd10 Gpr161 Intu Fuz Cdc73 Adcy10 Tulp3 Sufu Gli3 Ift140 Ift122 Ift52 Ift172 Ift57 Wdr19 Ttc21b Gli2 Gsk3b Dync2h1 Wdr35 Gli1 Shfm1 Ift88 Numb P4hb Hhat Adcy7 Psmc6 Ulk3 Adcy6 Spopl Mks1 Rpgrip1l Adcy5 Dzip1 Adcy4 Spop Psmc5 Adcy3 Adcy2 Prkar2a Psmc2 Adcy1 Psmd2 Prkacb Adcy9 Psmb9 Psmf1 Psmb8 Adcy8 Psme4 Prkar2b Hhip Skp1a Psmc1 Ofd1 Psmc4 Psmc3 Cul1 Psme3 Cdon Prkar1a Prkar1b Prkaca Psma7 Psma5 Psmb5 Psmb4 Ubc Psma4 Itch Psma3 Psmb7 Psma6 Psmb6 Psmb2 Psmb3 Psma2 Psmb1 Psma1 Psmd9 Gpc5 Smurf1 Psmd1 Psme2 Psme1 Psmd3 Psmd4 Psmb10 Psmd6 Psmd5 Psmd7 Smurf2 Adam17 Psmb11 Psmd8 Erlec1 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM%REACTOME DATABASE ID RELEASE 59%72202 Transport of Mature Transcript to Cytoplasm Nup85 Nup160 Nup50 Tpr Ndc1 Nup214 Aaas Nup210 Nup188 Nup54 Nup35 Nupl2 Nup62 Nup205 Nup155 Nup88 Pom121 Rae1 Nup93 Srsf2 Thoc7 Thoc6 Nxt1 Srsf3 Nup153 Slu7 Srsf11 Zc3h11a Magoh Cpsf1 Dhx38 Nup107 Thoc3 Srsf7 Thoc2 Thoc5 Thoc1 Srsf9 Ncbp1 Alyref Ncbp2 Srsf6 Fip1l1 Rbm8a Casc3 Sympk Nup37 Eif4a3 U2af1l4 Chtop Nxf7 Nup43 Srsf1 Nup133 Cpsf3 Cpsf2 Cpsf4 Nxf1 Ddx39b Upf3b Ddx39 Fyttd1 Wdr33 Rnps1 Poldip3 Magohb Cdc40 Srrm1 Slbp Eif4e Ranbp2 PI AND PC TRANSPORT BETWEEN ER AND GOLGI MEMBRANES%REACTOME DATABASE ID RELEASE 59%1483196 PI and PC transport between ER and Golgi membranes Pitpnb RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 59%110381 Resolution of AP sites via the single-nucleotide replacement pathway Apex1 Lig3 Xrcc1 Polb METAL SEQUESTRATION BY ANTIMICROBIAL PROTEINS%REACTOME DATABASE ID RELEASE 59%6799990 Metal sequestration by antimicrobial proteins Lcn2 Ltf S100a9 S100a8 RAF ACTIVATION%REACTOME DATABASE ID RELEASE 59%5673000 RAF activation Ppp2cb Ppp2r1b Ywhab Phb Map2k1 Map3k11 Ppp2ca Jak2 Mark3 Kras Map2k2 Nras Ppp2r1a Ppp2r5b Araf Raf1 Hras Brap Ppp2r5e Braf Ppp2r5c Ppp2r5d Ppp2r5a Ksr1 MISSPLICED LRP5 MUTANTS HAVE ENHANCED BETA-CATENIN-DEPENDENT SIGNALING%REACTOME DATABASE ID RELEASE 59%5339717 Misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling Kremen2 Kremen1 Dkk1 Dkk2 Dkk4 Lrp5 RAS SIGNALING DOWNSTREAM OF NF1 LOSS-OF-FUNCTION VARIANTS%REACTOME DATABASE ID RELEASE 59%6802953 RAS signaling downstream of NF1 loss-of-function variants Nf1 Kras Nras Hras METABOLISM OF INGESTED SEMET, SEC, MESEC INTO H2SE%REACTOME%R-HSA-2408508.2 Metabolism of ingested SeMet, Sec, MeSec into H2Se Cth Gnmt Scly Cbs Nnmt Ahcy Mat1a Hnmt TRANSCRIPTIONAL ACTIVATION OF CELL CYCLE INHIBITOR P21%REACTOME%R-HSA-69895.3 Transcriptional activation of cell cycle inhibitor p21 Cdkn1a Trp53 Pcbp4 Zfp385a ADENYLATE CYCLASE INHIBITORY PATHWAY%REACTOME%R-HSA-170670.1 Adenylate cyclase inhibitory pathway Gnai2 Adcy7 Gnai1 Adcy6 Adcy5 Adcy4 Adcy3 Gnai3 Adcy2 Adcy1 Gnat3 Adcy9 Gnal Adcy8 ACTIVATED POINT MUTANTS OF FGFR2%REACTOME%R-HSA-2033519.1 Activated point mutants of FGFR2 Fgf23 Fgf16 Fgf22 Fgf20 Fgf18 Fgf1 Fgf2 Fgf9 Fgf7 Fgf10 Fgf6 Fgfr2 Fgf4 Fgf3 REGULATION OF SIGNALING BY NODAL%REACTOME%R-HSA-1433617.1 Regulation of signaling by NODAL Acvr1b Nodal Lefty2 Dand5 Acvr2b Acvr2a Acvr1c Lefty1 Cer1 PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME DATABASE ID RELEASE 59%622323 Presynaptic nicotinic acetylcholine receptors Chrnb2 Chrne Chrna4 Chrna5 Chrnb4 Chrnb3 Chrnd Chrna3 Chrna1 Chrna6 Chrng Chrna2 G ALPHA (S) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 59%418555 G alpha (s) signalling events Pde4d Pde4c Pth2r Gpr150 Rxfp1 Rxfp2 Gpbar1 Arrb2 Pde10a Arrb1 Ptger4 Adrbk1 Ptger2 Iapp Vip Pth1r Pde3b Pde7b Rln3 Rln1 Htr7 Htr6 Pde8a Pde8b Htr4 Pth Pomc Calca Gpr15 Pde3a Pde2a Drd5 Pth2 Drd1 Adm Gnat3 Gpr20 Pde4a Pde4b Avp Avpr2 Hrh2 Gpr45 Pde7a Adcy7 Gngt1 Gng7 Adcy6 Adcy5 Adcyap1r1 Gng4 Adcy4 Adcy3 Crhr2 Adcyap1 Adcy2 Crhr1 Gcg Gngt2 Adcy1 Glp1r Gng10 Gcgr Adcy9 Gnaz Gpr27 Gpr25 Adcy8 Cga Lhb Crh Ptgdr Adm2 Mc5r Calcr Gnai2 Gnai1 Gnai3 Taar8b Taar1 Taar2 Taar5 Taar6 Taar9 Gng11 Gng13 Gng12 Gnb2 Adora2b Gnb1 Adora2a Gnb3 Gnb5 Mc2r Ghrhr Gnb4 Fshr Ghrh Adrb2 Lhcgr Glp2r Fshb Gng8 Sct Adrb1 Gip Gng3 Adrb3 Gng2 Nps Gipr Gpha2 Mc1r Ptgir Grk6 Grk5 Gpr176 Ramp1 Npsr1 Mc3r Calcrl Mc4r Ramp2 Ramp3 Pthlh Vipr2 Vipr1 Tshr Pde1b Pde1a Gpr83 Insl3 Pde11a Ppan Tshb Adrbk2 Gpr84 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI)%REACTOME DATABASE ID RELEASE 59%162710 Synthesis of glycosylphosphatidylinositol (GPI) Pigc Pigb Pigf Pigg Dpm2 Pigh Pigw Piga Pigv Pigx Pign Pigo Pigm Pigl TOLL LIKE RECEPTOR 5 (TLR5) CASCADE%REACTOME%R-HSA-168176.1 Toll Like Receptor 5 (TLR5) Cascade Ppp2r1a Btrc Mapk9 Nfkb2 Nfkb1 Ecsit Fbxw11 Skp1a Saa3 Ppp2r5d Mapkapk3 Tnip2 Myd88 Nod2 Cul1 Nod1 Dhx9 Vrk3 S100b Elk1 Mef2c Mapk10 Mef2a Tlr5 Map3k7 Dusp3 Mapk7 Peli1 Creb1 Mapkapk2 Irak2 Irak1 App Map2k6 Tab1 Tab2 Jun Mapk8 Tab3 Map3k1 Ripk2 Map2k7 Ager Map2k3 Map2k4 Map3k8 Atf2 Rela Nfkbia Peli3 Nfkbib Irak4 Fos Peli2 Ppp2cb Map2k1 Chuk Ppp2ca Ubc Mapk3 Rps6ka5 Mapk1 Ppp2r1b Dusp7 Rps6ka3 Dusp6 Rps6ka2 Rps6ka1 Traf6 Ikbkb Ube2v1 Ube2n Ikbkg Mapk11 Mapk14 Dusp4 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL%REACTOME DATABASE ID RELEASE 59%209560 NF-kB is activated and signals survival Ngf Nfkbia Irak1 Nfkb1 Ubc Traf6 Ikbkb Sqstm1 Ngfr Rela CONJUGATION OF PHENYLACETATE WITH GLUTAMINE%REACTOME DATABASE ID RELEASE 59%177162 Conjugation of phenylacetate with glutamine Acsm1 EPHB-MEDIATED FORWARD SIGNALING%REACTOME DATABASE ID RELEASE 59%3928662 EPHB-mediated forward signaling Actg1 Actb Hras Grin1 Yes1 Lyn Rasa1 Rhoa Ptk2 Ephb2 Arpc5 Arpc4 Fyn Limk1 Efnb3 Tiam1 Arhgef28 Limk2 Efnb1 Sdc2 Arpc1a Actr2 Actr3 Rac1 Arpc1b Pak1 Kalrn Wasl Ephb1 Arpc3 Ephb4 Grin2b Arpc2 Itsn1 Ephb6 Rock1 Efnb2 Ephb3 Rock2 CYCLIN D ASSOCIATED EVENTS IN G1%REACTOME%R-HSA-69231.3 Cyclin D associated events in G1 Ppp2cb Ppp2ca Cdkn1a Ppp2r1a Rb1 Rbl2 Cdkn2c Rbl1 Ubc E2f5 Skp1a E2f4 Ccnd2 E2f1 Cdkn2a Skp2 Cdkn1c Cul1 Cdk4 Cdkn2b Tfdp2 Cks1b Tfdp1 Ccnd1 Cdk6 Ppp2r1b E2f2 Mnat1 Ccnd3 E2f3 Ccnh Ppp2r2a Cdkn1b Cdk7 REGULATION OF NECROPTOTIC CELL DEATH%REACTOME%R-HSA-5675482.2 Regulation of necroptotic cell death Fas Casp8 Fadd Birc3 Tradd Fasl Birc2 Ripk1 Tnfrsf10b Tnfsf10 Traf2 Xiap ASSEMBLY OF THE ORC COMPLEX AT THE ORIGIN OF REPLICATION%REACTOME DATABASE ID RELEASE 59%68616 Assembly of the ORC complex at the origin of replication Orc4 Orc5 Orc2 Orc3 Orc6 Orc1 PYRIMIDINE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 59%500753 Pyrimidine biosynthesis Umps Cad Tyms Dctd Dhodh POST-TRANSCRIPTIONAL SILENCING BY SMALL RNAS%REACTOME DATABASE ID RELEASE 59%426496 Post-transcriptional silencing by small RNAs Ago2 Ago1 Tnrc6c Tnrc6b Tnrc6a Ago4 Ago3 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR)%REACTOME DATABASE ID RELEASE 59%1168372 Downstream signaling events of B Cell Receptor (BCR) Casp9 Tsc2 Pdgfrb Ppp2r1a Pdgfra Mlst8 Prkcb Vav1 Btrc Nfkb1 Egfr Gab1 Fbxw11 Mtor Phlpp1 Phlpp2 Map3k7 Ins2 Rela Nfkbia Nfkbib Cd86 Cdkn1a Psmd12 Pdgfb Psmd11 Cd80 Psmd14 Psmd13 Psmd10 Kit Ppp2r1b Ago2 Ago1 Tnrc6c Kras Ikbkb Insr Gsk3a Gsk3b Tnrc6b Shfm1 Tnrc6a Ikbkg Ago4 Ago3 Trat1 Irs2 Mdm2 Lck Pten Hbegf Irs1 Btc Ptpn11 Trib3 Psmc6 Egf Fgf23 Psmc5 Fgf22 Psmc2 Fgf20 Frs2 Psmd2 Nras Psmb9 Psmf1 Psmb8 Hras Psme4 Ppp2r5e Malt1 Mapkap1 Fgf1 Card11 Bad Ppp2r5c Rps6kb2 Fgf2 Skp1a Ppp2r5d Ppp2r5a Erbb2 Psmc1 Fgf9 Psmc4 Psmc3 Pik3cb Fgf7 Cul1 Foxo3 Psme3 Pik3cd Fgf6 Foxo1 Fgf4 Fgf3 Fyn Creb1 Rasgrp3 Bcl10 Ppp2r5b Rasgrp1 Ier3 Rel Pik3ca Nfkbie Cdkn1b Nr4a1 Prr5 Hgf Ppp2cb Pip5k1a Chuk Nrg2 Ereg Ppp2ca Nrg1 Akt2 Akt3 Psma7 Fgfr4 Psma5 Psmb5 Psmb4 Ubc Psma4 Nrg3 Psma3 Psmb7 Psma6 Nrg4 Akt1s1 Psmb6 Psmb2 Psmb3 Psma2 Psmb1 Psma1 Mapk3 Pip5k1b Akt1 Cd19 Mapk1 Pip5k1c Psmd9 Fgf16 Pip4k2b Pip4k2a Trp53 Fgf15 Pip4k2c Klb Pik3ap1 Fgf18 Them4 Psmd1 Psme2 Met Psme1 Rictor Psmd3 Psmd4 Psmb10 Pdpk1 Psmd6 Psmd5 Pik3r3 Psmd7 Pik3r1 Psmb11 Psmd8 Fgf10 Pik3r2 Mov10 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN%REACTOME DATABASE ID RELEASE 59%170822 Regulation of Glucokinase by Glucokinase Regulatory Protein Nup85 Nup160 Nup37 Nup50 Tpr Nup43 Nup133 Ndc1 Nup214 Aaas Nup210 Nup188 Nup54 Nup35 Nupl2 Nup62 Nup205 Nup155 Nup88 Pom121 Rae1 Nup93 Nup153 Gckr Ranbp2 Nup107 Gck CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE%REACTOME DATABASE ID RELEASE 59%442720 CREB phosphorylation through the activation of Adenylate Cyclase Creb1 Adcy3 Adcy1 Prkaca Prkacb Adcy8 RECRUITMENT AND ATM-MEDIATED PHOSPHORYLATION OF REPAIR AND SIGNALING PROTEINS AT DNA DOUBLE STRAND BREAKS%REACTOME%R-HSA-5693565.2 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Hist1h2bg Hist1h2bh Smarca5 Fam175a Hist1h2bp Kdm4a Hist1h2bm Pias4 Apbb1 Kdm4b Hist1h2bj Rnf168 Hist1h2bb Eya3 Ube2v2 Ubc Eya2 Eya1 Brcc3 Eya4 Trp53bp1 Rad50 Baz1b Mdc1 H2afx Uimc1 Babam1 Herc2 Nbn Bre Trp53 Mapk8 Kat5 Bard1 Ube2n Bap1 Whsc1 Hist1h3h Brca1 Chek2 Mre11a Ppp5c Atm Hist2h2be Hist3h2ba Abl1 Ube2i FASL CD95L SIGNALING%REACTOME%R-HSA-75157.2 FasL CD95L signaling Fas Casp8 Fadd Fasl IRS ACTIVATION%REACTOME%R-HSA-74713.2 IRS activation Grb10 Irs2 Ins2 Insr Irs1 DEFENSINS%REACTOME%R-HSA-1461973.1 Defensins Defb47 Defb15 Defb19 Tlr2 Defb14 Defb23 Defb12 Defb25 Ccr6 Defb18 Tlr1 Cd4 Gm15386 Defb36 Ccr2 Prss2 Art1 Defb29 ESTABLISHMENT OF SISTER CHROMATID COHESION%REACTOME DATABASE ID RELEASE 59%2468052 Establishment of Sister Chromatid Cohesion Stag2 Stag1 Pds5a Cdca5 Pds5b Wapal Smc3 Smc1a Rad21 Esco2 Esco1 DEFECTIVE ST3GAL3 CAUSES MCT12 AND EIEE15%REACTOME DATABASE ID RELEASE 59%3656243 Defective ST3GAL3 causes MCT12 and EIEE15 Omd Prelp Kera Lum Ogn Fmod GLYCINE DEGRADATION%REACTOME DATABASE ID RELEASE 59%6783984 Glycine degradation Gcsh Dld Amt Gldc CELL REDOX HOMEOSTASIS%REACTOME%R-HSA-1222541.1 Cell redox homeostasis FC EPSILON RECEPTOR (FCERI) SIGNALING%REACTOME DATABASE ID RELEASE 59%2454202 Fc epsilon receptor (FCERI) signaling Akap9 Ppp2r1a Btrc Mapk9 Nfkb1 Fbxw11 Mapk10 Map3k7 Cdc34 Ppp3cb Tab1 Rac1 Tab2 Mapk8 Jun Tab3 Map3k1 Pak1 Ppp3ca Map2k7 Nfatc2 Ppp3r1 Map2k4 Nfatc1 Nfatc3 Rela Nfkbia Csf2 Cd86 Jak1 Cd80 Vav2 Frs2 Nras Frs3 Rasgrf1 Psmf1 Raf1 Psme4 Il5ra Fgf1 Bad Il17rd Fgf2 Skp1a Cnksr1 Csk Cnksr2 Ms4a2 Erbb2 Fgf9 Ptk2 Fgf7 Cul1 Psme3 Fgf6 Fgf4 Fgf3 Ppp5c Ranbp9 Ppp2cb Shc1 Lamtor2 Chuk Nrg2 Ppp2ca Shc3 Nrg1 Akt2 Akt3 Shc2 Psma7 Artn Nrtn Plcg1 Brap Psmb5 Gab2 Psmb4 Ubc Nrg3 Psmb7 Nrg4 Psmb6 Psmb2 Psmb3 Psmb1 Mapk3 Akt1 Mapk1 Ksr1 Ptpra Dusp16 Dusp10 Map3k11 Pip4k2b Pip4k2a Trp53 Pip4k2c Paqr3 Pik3ap1 Psme2 Psme1 Ncam1 Sos1 Rictor Braf Txk Psmb10 Apbb1ip Ahcyl1 Psmb11 Csf2rb2 Tec Rapgef2 Grap2 Csf2ra Itk Mov10 Lcp2 Casp9 Actn2 Nf1 Tsc2 Pdgfrb Pdgfra Mlst8 Kbtbd7 Vav1 Il2rg Arrb2 Egfr Gab1 Arrb1 Mtor Ret Phlpp1 Vwf Phlpp2 Ins2 Sptan1 Rasgrp2 Pspn Map2k1 Rbx1 Fgg Cdkn1a Map2k2 Cul3 Psmd12 Pdgfb Psmd11 Rasgef1a Psmd14 Rasa3 Lyn Rasa4 Psmd13 Psmd10 Prkcq Il2 Rasa2 Rasa1 Nefl Spred3 Kit Spred2 Grin2a Spta1 Spred1 Il5 Sptbn4 Ppp2r1b Ywhab Ube2d1 Ago2 Ago1 Tnrc6c Kras Traf6 Ikbkb Insr Ube2v1 Gsk3a Gsk3b Tnrc6b Ube2n Gdnf Shfm1 Tnrc6a Pak2 Ikbkg Ago4 Ago3 Itpr1 Trat1 Irs2 Mdm2 Lck Syngap1 Pten Hbegf Irs1 Il3ra Btc Il2ra Il2rb Itpr3 Ptpn11 Angpt1 Itpr2 Trib3 Psmc6 Egf Fgf23 Psmc5 Fgf22 Mark3 Psmc2 Fgf20 Psmd2 Dab2ip Tek Psmb9 Psmb8 Araf Hras Grin1 Malt1 Ppp2r5e Card11 Mapkap1 Dlg4 Ppp2r5c Rps6kb2 Ppp2r5d Ppp2r5a Psmc1 Psmc4 Psmc3 Pik3cb Foxo3 Sptbn2 Pik3cd Foxo1 Sptbn1 Itgb3 Fyn Creb1 Phb Grin2c Rasgrp4 Plcg2 Rasgrp3 Pebp1 Bcl10 Fcer1a Ppp2r5b Syk Rasgrp1 Ier3 Tln1 Pik3ca Cdkn1b Fga Fos Fgb Grin2d Grin2b Nr4a1 Sptb Vav3 Prr5 Hgf Gfra2 Gfra3 Pip5k1a Gfra4 Ereg Fcer1g Jak2 Pea15a Itga2b Rap1a Jak3 Wdr83 Btk Camk2d Rap1b Camk2a Fgfr4 Camk2b Psma5 Rasal3 Rasal2 Psma4 Psma3 Psma6 Akt1s1 Vcl Camk2g Psma2 Psma1 Gfra1 Pip5k1b Cd19 Pip5k1c Psmd9 Dusp7 Iqgap1 Fgf16 Dusp6 Dusp9 Fgf15 Dusp8 Klb Fgf18 Them4 Psmd1 Met Fn1 Rasal1 Dusp1 Psmd3 Psmd4 Pdpk1 Lat2 Psmd6 Psmd5 Dusp2 Pik3r3 Psmd7 Pik3r1 Dusp5 Psmd8 Fgf10 Pik3r2 Dusp4 FGFR3 MUTANT RECEPTOR ACTIVATION%REACTOME DATABASE ID RELEASE 59%2033514 FGFR3 mutant receptor activation Fgf1 Fgf23 Fgf16 Fgf2 Fgf20 Fgf18 Fgf9 Fgfr3 Fgf4 SYNTHESIS OF BILE ACIDS AND BILE SALTS%REACTOME DATABASE ID RELEASE 59%192105 Synthesis of bile acids and bile salts Akr1c6 Acox2 Hsd17b4 Cyp7a1 Cyp7b1 Baat Acot8 Abcb11 Nr1h4 Ptgis Ch25h Akr1c18 Akr1c21 Osbpl1a Cyp8b1 Osbp Osbpl3 Osbpl9 Osbpl6 Osbpl7 Rxra Osbpl2 Slc27a5 Cyp46a1 Cyp27a1 Akr1d1 Amacr Hsd3b7 Cyp39a1 Ncoa1 Ncoa2 Slc27a2 PROGRESSIVE TRIMMING OF ALPHA-1,2-LINKED MANNOSE RESIDUES FROM MAN9 8 7GLCNAC2 TO PRODUCE MAN5GLCNAC2%REACTOME%R-HSA-964827.2 Progressive trimming of alpha-1,2-linked mannose residues from Man9 8 7GlcNAc2 to produce Man5GlcNAc2 Man1c1 Man1a Man1a2 RHO GTPASES ACTIVATE RHOTEKIN AND RHOPHILINS%REACTOME DATABASE ID RELEASE 59%5666185 RHO GTPases Activate Rhotekin and Rhophilins Rhpn2 Ropn1 Rtkn Lin7b Rhpn1 Rhoa Rhob Rhoc ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON%REACTOME DATABASE ID RELEASE 59%936964 Activation of IRF3 IRF7 mediated by TBK1 IKK epsilon Irf7 Ticam2 Tbk1 Ticam1 Tlr4 Tlr3 Ly96 Cd14 Irf3 Ikbke Tank Ubc Traf3 Ptpn11 ION TRANSPORT BY P-TYPE ATPASES%REACTOME DATABASE ID RELEASE 59%936837 Ion transport by P-type ATPases Fxyd1 Fxyd4 Fxyd6 Atp7b Atp8b2 Camk2d Atp1a1 Camk2a Camk2b Atp10b Atp1b2 Atp11c Atp1a2 Atp7a Atp12a Atp1a3 Atp13a5 Atp13a4 Atp13a2 Atp1b3 Atp8b1 Atp1b1 Atp13a1 Atp8a2 Camk2g Atp8b3 Pdzd11 Atp2a1 Atp2a3 Atp2a2 Atp9a Atp9b Atp10d Atp10a Atp2c1 Atp2b3 Atp2b4 Atp8a1 Atp2b1 Atp2b2 Atp11a Sri Atp4a Fxyd7 Atp4b Atp2c2 Atp11b Cutc TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX%REACTOME DATABASE ID RELEASE 59%445989 TAK1 activates NFkB by phosphorylation and activation of IKKs complex Chuk Nfkb2 Nfkb1 Saa3 Myd88 Nod2 Nod1 Dhx9 S100b Map3k7 Irak2 Irak1 App Tab1 Traf6 Tab2 Tab3 Ikbkb Ube2v1 Ripk2 Ube2n Ager Ikbkg Rela Nfkbia Nfkbib CGMP EFFECTS%REACTOME%R-HSA-418457.1 cGMP effects Pde3a Pde3b Pde9a Pde2a Prkg2 Pde5a Pde1b Pde1a Itpr1 Pde10a Kcnmb2 Pde11a Kcnma1 Kcnmb4 Mrvi1 Kcnmb1 PI3K EVENTS IN ERBB4 SIGNALING%REACTOME DATABASE ID RELEASE 59%1250342 PI3K events in ERBB4 signaling Nrg2 Ereg Nrg3 Hbegf Nrg4 Nrg1 Btc Pik3r1 Pik3ca GLYCOLYSIS%REACTOME DATABASE ID RELEASE 59%70171 Glycolysis Hk1 Ppp2cb Gapdhs Ppp2ca Eno1b Ppp2r1a Hk2 Hk3 Ppp2r5d Ppp2r1b Aldoc Aldob Aldoa Pfkfb4 Eno2 Eno3 Tpi1 Pgk2 Eno1 Pgk1 Pfkm Pfkp Pfkl Gpi1 Pfkfb3 Pfkfb2 Pgam1 Pgam2 Pfkfb1 Gck AQUAPORIN-MEDIATED TRANSPORT%REACTOME%R-HSA-445717.1 Aquaporin-mediated transport Gngt1 Adcy7 Gng7 Adcy6 Adcy5 Gng4 Adcy4 Adcy3 Adcy2 Gngt2 Prkar2a Adcy1 Aqp11 Aqp7 Gng10 Prkacb Aqp12 Aqp6 Adcy9 Mip Adcy8 Aqp2 Aqp3 Rab11fip2 Prkar2b Rab11a Aqp1 Myo5b Gng11 Gng13 Gng12 Aqp9 Gnb2 Aqp5 Gnb1 Aqp4 Gnb3 Avp Prkar1a Gnb5 Prkar1b Avpr2 Aqp8 Gnb4 Prkaca Gng8 Gng3 Gng2 MITOTIC SPINDLE CHECKPOINT%REACTOME%R-HSA-69618.2 Mitotic Spindle Checkpoint Cdc23 Ube2d1 Cdc27 Bub1b Cdc16 Cdc20 Ube2c Anapc16 Ube2e1 Anapc7 Anapc4 Anapc5 Anapc1 Anapc2 Bub3 Mad2l1 Mad1l1 Anapc15 Anapc11 Anapc10 COPI-INDEPENDENT GOLGI-TO-ER RETROGRADE TRAFFIC%REACTOME%R-HSA-6811436.1 COPI-independent Golgi-to-ER retrograde traffic Dctn2 Pafah1b1 Dctn3 Rab3gap1 Dync1h1 Dynll2 Bicd2 Bicd1 Pla2g6 Pla2g4a Dync1i1 Pafah1b3 Pafah1b2 Dctn5 Dctn6 Dctn1 Dctn4 Agpat3 Dync1li2 Dynll1 Dync1li1 Galnt1 Galnt2 Rab18 Dync1i2 Rab6b Rab6a G2 M DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 59%69473 G2 M DNA damage checkpoint Fam175a Pias4 Ywhag Ywhae Rnf168 Trex1 Rfc5 Ube2v2 Rfc3 Cdk1 Brcc3 Trp53bp1 Rfc2 Rad50 Uimc1 Rfc4 Babam1 Nbn Atrip Dna2 Bard1 Chek2 Rpa2 Rpa1 Mre11a Atm Hist2h2be Hist3h2ba Rpa3 Top3a Rad17 Hist1h2bg Hist1h2bh Chek1 Wee1 Ywhaz Cdc25c Ywhah Sfn Hist1h2bp Rbbp8 Hist1h2bm Topbp1 Hist1h2bj Hist1h2bb Rad9a Blm Rad1 Rad9b Hus1 Mdc1 H2afx Exo1 Brip1 Ywhab Herc2 Bre Trp53 Kat5 Wrn Ube2n Whsc1 Hist1h3h Brca1 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF)%REACTOME%R-HSA-1655829.1 Regulation of cholesterol biosynthesis by SREBP (SREBF) Nfyb Lss Nfyc Sar1b Mvk Helz2 Mtf1 Srebf2 Pmvk Insig2 Insig1 Sec23a Nfya Sp1 Sqle Chd9 Fasn Cyp51 Elovl6 Gpam Sec24a Sec24b Crebbp Sec24d Sec24c Mbtps1 Smarcd3 Mbtps2 Ran Idi1 Med1 Tbl1x Ppara Acacb Fdps Acaca Ggps1 Sc5d Tm7sf2 Fdft1 Rxra Scd1 Carm1 Kpnb1 Scap Dhcr7 Ncoa1 Mvd Ncoa6 Ncoa2 Tbl1xr1 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE%REACTOME%R-HSA-532668.2 N-glycan trimming in the ER and Calnexin Calreticulin cycle Vcp Canx Ganab Calr Os9 Rnf185 Ubxn1 Derl2 Rnf5 Rnf139 Man1b1 Uggt2 Pdia3 Edem3 Amfr Trim13 Uggt1 Edem2 Ubc Edem1 Rnf103 Syvn1 Sel1l March6 Ngly1 Psmc1 Mlec Mogs Derl1 Engase Rad23b Prkcsh ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME DATABASE ID RELEASE 59%176814 Activation of APC C and APC C:Cdc20 mediated degradation of mitotic proteins Psmc6 Psmc5 Nek2 Psmc2 Psmd2 Psmb9 Psmf1 Psmb8 Psme4 Cdk1 Psmc1 Ccna1 Psmc4 Psmc3 Ccna2 Anapc15 Psme3 Anapc11 Anapc10 Pttg1 Bub1b Psmd12 Plk1 Psma7 Psmd11 Psmd14 Psma5 Psmb5 Psmb4 Ubc Psmd13 Bub3 Psmd10 Psma4 Psmb7 Psma3 Psma6 Psmb6 Psmb2 Mad2l1 Psmb3 Psmb1 Psma2 Psma1 Cdc23 Psmd9 Ube2d1 Cdc27 Cdc16 Cdc20 Ube2c Anapc16 Ube2e1 Anapc7 Psmd1 Shfm1 Psme2 Anapc4 Anapc5 Psme1 Anapc1 Anapc2 Psmd3 Psmd4 Psmb10 Psmd6 Psmd5 Psmd7 Psmb11 Psmd8 SYNTHESIS OF IPS IN THE ER LUMEN%REACTOME DATABASE ID RELEASE 59%1855231 Synthesis of IPs in the ER lumen Minpp1 RRNA MODIFICATION IN THE MITOCHONDRION%REACTOME%R-HSA-6793080.3 rRNA modification in the mitochondrion Ftsj2 Rnmtl1 Nsun4 Tfb1m Mterf4 Mrm1 PROLINE CATABOLISM%REACTOME%R-HSA-70688.1 Proline catabolism Aldh4a1 Prodh ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS%REACTOME DATABASE ID RELEASE 59%1296041 Activation of G protein gated Potassium channels Gngt1 Gng7 Gng4 Kcnj5 Kcnj9 Kcnj10 Gngt2 Kcnj3 Gng10 Kcnj16 Kcnj15 Gabbr2 Gabbr1 Kcnj2 Gng12 Kcnj12 Gnb2 Gnb1 Kcnj4 Gnb3 Gng8 Kcnj6 Gng3 Gng2 DISEASES OF GLYCOSYLATION%REACTOME%R-HSA-3781865.1 Diseases of glycosylation Agrn Lum Notch1 Adamts13 Sbspon Adamts14 Adamts15 Spon2 Thsd7a Spon1 Adamts3 Adamts6 Omd Prelp Adamts7 Kera Adamts2 Ogn Thbs1 Thsd7b Muc1 Muc4 Thbs2 Adamts12 Thsd4 Muc15 Bgn Dcn Adamts19 Muc20 Adamts10 Thsd1 Bcan Sspo Muc13 Cspg4 Cspg5 Adamts20 Cfp Ncan Vcan Adamtsl3 Sdc3 Adamtsl4 Sdc4 Adamts4 Notch4 Adamtsl1 Gpc6 Adamts1 Adamtsl2 Sdc2 Gpc3 Sdc1 Gpc5 Sema5a Gpc2 Gpc4 Dag1 Adamts8 Fmod Adamts5 Notch3 Adamtsl5 Notch2 Adamts18 Adamts16 Hspg2 Gpc1 Sema5b COLLAGEN DEGRADATION%REACTOME%R-HSA-1442490.3 Collagen degradation Adam10 Phykpl Col16a1 Col15a1 Col9a1 Col9a2 Col9a3 Mmp1a Mmp13 Mmp14 Col25a1 Mmp15 Mmp11 Col23a1 Mmp12 Ctsb Adam9 Ctsk Mmp19 Col26a1 Elane Ctsd Mmp10 Furin Tmprss6 Mmp2 Mmp9 Mmp20 Col17a1 Col12a1 Col13a1 Mmp3 Adam17 Col14a1 Col19a1 Mmp8 Mmp7 Col18a1 RORA ACTIVATES GENE EXPRESSION%REACTOME DATABASE ID RELEASE 59%1368082 RORA activates gene expression Med1 Nr1d1 Tbl1x Ppara Helz2 Chd9 Clock Arntl Ppargc1a Sirt1 Rora Ncor1 Rxra Carm1 Nrip1 Crebbp Cpt1a Ep300 Srebf1 Ncoa1 Smarcd3 Npas2 Ncoa6 Tbl1xr1 Ncoa2 Hdac3 G ALPHA (Z) SIGNALLING EVENTS%REACTOME%R-HSA-418597.2 G alpha (z) signalling events Gngt1 Adcy7 Rgs17 Gng7 Adcy6 Prkcd Adcy5 Prkce Gng4 Adcy4 Adcy3 Adcy2 Prkcg Gngt2 Rgs19 Adcy1 Gng10 Gnaz Adcy9 Prkcb Adcy8 Prkca Adra2a Adra2c Prkcq Adra2b Rgs20 Prkch Gnai2 Rgs4 Gnai1 Rgsl1 Gnai3 Gnat3 Gng11 Gng13 Gng12 Gnb2 Gnb1 Gnb3 Gnb5 Gnb4 Gng8 Gng3 Gng2 TANDEM PORE DOMAIN POTASSIUM CHANNELS%REACTOME%R-HSA-1296346.1 Tandem pore domain potassium channels Kcnk9 Kcnk7 Kcnk6 Kcnk1 Kcnk2 Kcnk13 Kcnk3 Kcnk10 Kcnk4 Kcnk18 Kcnk16 DEFECTIVE GALNT12 CAUSES COLORECTAL CANCER 1 (CRCS1)%REACTOME%R-HSA-5083636.1 Defective GALNT12 causes colorectal cancer 1 (CRCS1) Muc15 Muc20 Muc1 Muc4 Muc13 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21%REACTOME DATABASE ID RELEASE 59%187577 SCF(Skp2)-mediated degradation of p27 p21 Psmc6 Psmc5 Psmc2 Psmd2 Psmb9 Psmb8 Psmf1 Ccne1 Cdk2 Skp1a Ccne2 Psmc1 Ccna1 Psmc4 Skp2 Psmc3 Cul1 Ccna2 Cdk4 Psme3 Cks1b Ptk6 Ccnd1 Cdkn1b Cdkn1a Psmd12 Psma7 Psmd11 Psmd14 Psma5 Psmb5 Psmb4 Psmd13 Ubc Psmd10 Psma4 Psma3 Psmb7 Psma6 Psmb6 Psmb2 Psmb3 Psma2 Psmb1 Psma1 Psmd9 Psmd1 Shfm1 Psme2 Psme1 Psmd3 Psmd4 Psmb10 Psmd6 Psmd5 Psmd7 Psmd8 LECTIN PATHWAY OF COMPLEMENT ACTIVATION%REACTOME%R-HSA-166662.3 Lectin pathway of complement activation Mbl2 Fcnb O-LINKED GLYCOSYLATION OF MUCINS%REACTOME DATABASE ID RELEASE 59%913709 O-linked glycosylation of mucins Muc15 St6galnac4 Wbscr17 St6galnac3 Muc20 Chst4 Muc13 St3gal4 Gcnt7 C1galt1 Kcna6 St6galnac2 C1galt1c1 Gcnt1 Galntl5 Gcnt3 A4gnt Galnt12 Galnt13 B3gnt3 St3gal1 Galnt10 B3gnt2 St3gal2 Galnt11 B3gnt7 Galnt16 B4galt5 Galnt1 B3gnt6 Galnt18 Galnt2 B3gnt5 Galnt14 B4galt6 B3gnt4 Galnt15 B3gnt9 Galnt7 B3gnt8 Galnt3 Galnt6 B3gntl1 Muc1 St6gal1 Muc4 Galnt4 Galnt5 SIGNALING PATHWAYS%REACTOME DATABASE ID RELEASE 59%162582 Signaling Pathways Prkcb Dnajb1 Map2k5 Ncoa3 Parp1 Vegfa Ctbp1 Gpr31b Porcn Ctbp2 Dkk1 Tnks Fzd6 Dkk2 Wnt3a Tnks2 Kremen2 Kremen1 Dkk4 Fzd4 Fzd5 Fzd8 Lrp6 Tcf7l2 Lrp5 Rnf43 F2rl3 F2rl2 Csk Pla2g4a Gna11 Gna12 F2r Gnaq Gna15 F2 Gna13 Gna14 Adam10 Bcr Lrat Bag4 Gab2 Csn2 Itch Wwp1 Nedd4 Gfap Atp2a1 Atp2a3 Atp2a2 Csnk1g2 Tgfbr1 Fkbp1a Tgfbr2 Adam17 Jag2 Dll1 Dll4 Erlec1 Jag1 Maml2 Maml1 Rptor Men1 Kat2b Kat2a Rragd Rragb Rragc Rraga Rxrg Apoe Ski Notch4 Rxrb Junb Rxra Kat5 Notch3 Notch2 Lck Ptpn6 Casp2 Ptpn11 Tbl1xr1 Pafah1b1 Rara Rarb Mks1 Rpgrip1l Ywhag Ccnc Mapkapk5 Hsp90aa1 Sp1 B9d2 Prkar2b Hhip Cdk1 Ofd1 Atp1b4 Tgif2 Tgif1 Rnf111 Clasp1 Prkg2 Csnk1e Mapre1 Trim33 Crebbp Prkaca Rbpj Ppp3cc Esr1 Ppp1r1b Ckap5 Plk1 Maml3 Ube2d3 Rarg Smurf1 Cgn Stub1 Prkcz Uchl5 Nedd8 Ppp1ca Strap Ppp1r15a Mtmr4 Pmepa1 Ccnk Mamld1 Bambi Usp15 Mmp3 Ncoa2 Pgr Prkaa2 Ar Cdk9 Cdk8 Skil Smad1 Prkaa1 Hdac2 Jun Smad4 Smad2 Smad7 Smad3 Ccnt1 Nedd4l Ep300 Ccnt2 Tbl1x Tsc1 Gpr161 Intu Fuz Adcy10 Tulp3 Ift140 Ift122 Gga3 Ift52 Ift172 Ift57 Wdr19 Ttc21b Gli2 Dync2h1 Wdr35 Gli1 Ift88 Ptprk Adam12 Eps15l1 Epn1 Lrig1 Spry1 Prkag2 Prkag1 Prkag3 Usp9x Ncor1 Ncor2 Lamtor1 Ppard Ppm1a Lamtor5 Wwox Yap1 Lamtor4 Slc24a1 Myc Wwtr1 Prkab1 Cdkn2b Stk11 Prkab2 Smurf2 Igf2bp1 Bmp2 Dvl1 Pik3c3 Akap13 Arhgap11a Depdc7 Cyp26c1 Iqgap3 Iqgap2 Mkl1 Dvl3 Actb Pik3r4 Dtx4 Kdm4c Scai Kif14 Ect2 Dvl2 Wipf3 Wipf2 Pfn2 Pfn1 Rhof Rhoh Wipf1 Srf Wasf2 Rhod Arhgdig Wasf3 Arpc5 Arpc4 H2afj Wasf1 H2afb2 Diap1 Diap3 Myo9b Arhgap17 Cybb Cyba Arhgap18 Arhgap12 Arhgap19 Klc3 Klc2 Sppl2a Klc4 Sppl2b Arhgef10l Rnf31 Gmip Arhgap15 Cflar Sos2 Kdm1a Racgap1 Fam13b Rtkn Hist2h2be Was Trio Syde2 Syde1 Hist2h2ac Dlc1 Ocrl H3f3b H3f3a Inpp5b Hist1h2bg Hist1h2bh Srgap2 Rhobtb2 Arhgap39 Actg1 Rhobtb1 Depdc1b Hist1h2bp Hist1h2bm Ppp1r14a Cyp26b1 Daam1 Hist1h2bj Srgap3 Hist1h2bb Srgap1 Gdi2 Gdi1 Mcf2 Hmha1 Nckap1l Mcf2l Arhgap10 Clip3 Traf1 Noxa1 Arhgap22 Arhgap21 Trip10 Klc1 Myo9a Arhgap20 Abi1 Abi2 Arhgap26 Cttn Arhgef7 Arpc1a Arhgap31 Arhgap32 Arpc1b Arhgap25 Cyp26a1 Arhgef3 Arhgef4 Arhgef1 Adh1 Arhgef2 Hist1h3d Arhgap23 Adh4 Arhgap29 Arhgap24 Arhgef9 Nckap1 Prex1 Hist1h2ak Noxo1 Arhgap28 Hist1h2ag Ppp1r12b Arhgap40 Arhgap42 Arhgap44 Arhgap36 Itsn1 Cyfip1 Hist1h2ah Cyfip2 Rhpn2 Ncf4 Hist2h3c1 Ppp1r12a Arhgap33 Ncf2 Rhpn1 Ncf1 E2f3 Tlr9 Igf1r Irs4 Igf2 Igf1 Grb7 Disp2 Casp9 Prkcd Prkce Actn2 Nf1 Prkcg Tsc2 Pdgfrb Stat5b Pdgfra Stat5a Plg Mlst8 Kbtbd7 Prkca Vav1 Il2rg Arrb2 Egfr Gab1 Arrb1 Mtor Ret Phlpp1 Adrbk1 Ntrk1 Ntrk2 Vwf Ralb Phlpp2 Rala Rtn4 Aph1b Omg Epas1 Sox2 Mmp9 Ihh Shh Dhh Cltb Notum Pspn Col4a5 Map2k1 Rbx1 Crkl Fgg Cdkn1a Map2k2 Cul3 Psmd12 Pdgfb Psmd11 Col9a1 Rasgef1a Col9a2 Col9a3 Psmd14 Rasa3 Rasa4 Psmd13 Psmd10 Il2 Rasa2 Rasa1 Nefl Spred3 Kit Spred2 Pdgfd Grin2a Spred1 Il5 Ppp2r1b Ywhab Ago2 Ago1 Ptpn12 Tnrc6c Kras Insr Gsk3a Gsk3b Tnrc6b Gdnf Shfm1 Tnrc6a Ago4 Ago3 Itpr1 Trat1 Irs2 Mdm2 Syngap1 Pten Hbegf Irs1 Il3ra Btc Il2ra Il2rb Rab6a Itpr3 Angpt1 Itpr2 Trib3 Psmc6 Egf Fgf23 Psmc5 Pag1 Fgf22 Mark3 Psmc2 Fgf20 Psmd2 Dab2ip Prkacb Nos3 Tek Psmb9 Psmb8 Araf Hras Grin1 Sphk1 Ppp2r5e Shb Mapkap1 Dlg4 Ppp2r5c Rps6kb2 Ppp2r5d Ppp2r5a Psmc1 Psmc4 Psmc3 Pik3cb Foxo3 Pik3cd Axl Foxo1 Itgb3 Sh2d2a Fyn Creb1 Phb Spp1 Grin2c Stat1 Rasgrp4 Rasgrp3 Stat6 Pebp1 Camk4 Ngef Ppp2r5b Rasgrp1 Ier3 Tln1 Pik3ca Col4a3 Arhgef26 Col4a2 Fgd2 Thbs4 Net1 Col4a4 A2m Col4a1 Fgd4 Cdkn1b Hist3h2ba Fga Fgd1 Fgb Fgd3 Grin2d Lep Stard13 Thbs1 Ffar4 Abl1 Arhgef17 Grin2b Nr4a1 Arhgef10 Vav3 Prr5 Nox3 Thbs3 Nox1 Hgf Thbs2 Cit Gfra2 Plekhg5 Arhgef19 Gfra3 Pip5k1a Arhgef16 Arhgef15 Gfra4 Nf2 Ereg Abr Jak2 Arhgef18 Pea15a Itga2b Plekhg2 Rap1a Arhgef40 Jak3 Arap3 Wdr83 Btk Camk2d Cftr Rap1b Ophn1 Camk2a Stard8 Fgfr4 Arap2 Camk2b Arap1 Arhgef38 Psma5 Rasal3 Arhgef39 Gopc Plat Rac3 Rasal2 Psma4 Ppp1cb Fmnl2 Psma3 Fmnl3 Psma6 Arhgef37 Akt1s1 H2afz Vcl Camk2g Baiap2 H2afx Psma2 Fmnl1 Psma1 Brk1 Gfra1 Pip5k1b Pkn2 Pkn1 Cd19 Pip5k1c Evl Rit2 Tiam2 Psmd9 Dusp7 Tiam1 Ngf Pkn3 Iqgap1 Aatf Rit1 Actr2 Fgf16 Dusp6 Ralgds Actr3 Dusp9 Lin7b Prdm4 Hist2h2aa1 Pcsk6 Fgf15 Dusp8 Mag Kif5a Kif5b Psen2 Klb Kalrn Pcsk5 Fgf18 Mylk Them4 Ncstn Rhot1 Sqstm1 Psmd1 Lingo1 Met Rhot2 Nckipsd Fn1 Kidins220 Bcar1 Arhgap8 Bcl2l11 Arhgap9 Ngfrap1 Rasal1 Dusp1 Arhgap1 Ropn1 Psmd3 Arhgap5 Psmd4 Arhgap4 Pdpk1 Arhgdib Psmd6 Arhgap6 Psmd5 Dusp2 Arhgdia Pik3r3 Rhoj Arpc3 Psmd7 Crk Prc1 Pik3r1 Ktn1 Dusp5 Dnal4 Arpc2 Ralbp1 Smpd2 Psmd8 Maged1 Rhoq Fgf10 Ngfr Pik3r2 Rhou Dusp4 Hdac3 Rhov Vcp Akap9 Nphp4 Ppp2r1a Ywhae Khdrbs2 Btrc Gpnmb Khdrbs1 Khdrbs3 Tax1bp1 Nfkb1 Saa3 Mapkapk3 Lrrk2 Myd88 Nr3c1 Stap2 Dok1 S100b Hif1a Sfpq Map3k7 Irak1 App Tab1 Tab2 Tab3 Ripk2 Rela Il6 Nfkbia Csf2 Tnfrsf1a Fcer2a Cd86 Ccl5 Tnf Jak1 Fpr1 Ccr1 Cd80 Xiap Ptafr Tyk2 Stat3 Casp3 Cxcl3 Cxcl1 Atp6v0d2 Atp6v0d1 Ccl20 Atp6v0b Ccr2 Ube2m Atp6v1c2 Ccr5 Atp6v1c1 Cxcl10 Atp6v0e Atp6ap1 Atp6v1g3 Atp6v1e2 Atp6v1e1 Atp6v0e2 Atp6v1a Atp6v1b1 Tcirg1 Atp6v1b2 Cma1 Atp6v1g1 Atp6v1g2 Atp6v0a1 Atp6v0a2 Atp6v1h Atp6v0a4 Atp6v1d Atp6v1f Ptpn1 Srms Il6ra Hist1h3h Tec Grap2 Akr1c6 Ldlr Lrp1 Bco1 Bco2 Akr1c18 Apoa4 Akr1c21 Apoa2 Apom Rdh11 Ins2 Pnlip Ccnd3 Sptan1 Sec13 Sh3gl1 Stam Hgs Stam2 Eps15 Clps Apoc2 Apoc3 Gpihbp1 Eif4b Ttr Lpl St3gal4 Spta1 Sptbn4 Rbp2 Rbp1 Birc3 Birc2 Akr1b10 Traf6 Ikbkb Rbp4 Ikbkg Cab39 Eif4e Strada Stradb Cab39l Eef2k Eif4g1 Eif4ebp1 Lrp2 Plb1 Lrp12 Lrp10 Cga Lhb Sptbn2 Sptbn1 Adgre5 B4galt1 Sptb Muc20 Socs3 Rag2 Rag1 Cdc42ep3 Agrn Cdc42ep5 Etv4 Hgfac Mfng Serpine1 Cilp Rbfox2 Hdac4 Ptpn2 Hdac5 Sept7 Rfng Lfng Esrp2 Crabp2 Tia1 Cdc42ep2 Tial1 Cdc14b Mapk4 Mapk6 Mdk Mib2 Hdac10 Neurl1a Neurl1b Hey1 Hdac11 Hey2 Hdac7 Hdac6 Hdac9 Hdac8 Hes5 Mib1 Heyl Hes1 Lamc1 Ap2m1 Nrp1 Csnk2a2 Nrp2 Ap2a1 Ap2a2 Cntn1 Lamb1 Sh3gl2 Itgav Dnm2 Rps6ka5 Ap2s1 Dnm1 Rps6ka3 Rps6ka2 Rps6ka1 Lama1 Vav2 Clta Ap2b1 Csnk2b Cltc Numb Dnm3 Itga2 Cdon Napepld Rdh12 Abca4 Rlbp1 Rdh5 Stra6 Cyp4v3 Hsd17b1 Rdh10 Rpe65 Myo7a Dhrs9 Hsd17b6 BC089597 Rbp3 Rdh8 Sdr9c7 Ccne1 Hdac1 Gas1 Polr2i Gas8 Polr2j Evc2 Boc Smo Polr2c Evc Polr2d Iqce Polr2b Polr2g Ptch1 Pde6a Gucy2e Rcvrn Pde6b Gucy2f Cnga1 Polr2a Rgs9bp Fntb Guca1a Sag Guca1b Gtf2f1 Ppef1 Ncbp1 Metap2 Ncbp2 Metap1 Gtf2f2 Grk1 Pde6g Pde3b Apc Axin1 Amer1 Csnk1a1 Gpr143 Ctnnb1 Kdr Flt1 Ube2d1 Cdc14a Cdc20 Avp Avpr1a Avpr2 Avpr1b Gngt1 Gng7 Adcyap1r1 Gng4 Adcyap1 Gcg Gngt2 Glp1r Gng10 Gcgr Fabp5 Cav1 Gng11 Gng13 Gng12 Gnb2 Gnb1 Cpt1b Gnb3 Gnb5 Ghrhr Cpt1a Gnb4 Ghrh Glp2r Gng8 Sct Gip Gng3 Gng2 Gipr Aldh1a1 Psap Chek1 Ywhaz Cdc25c C3 Ywhah Sfn Tnfaip3 Usp21 Otud7b Usp2 Usp4 Cyld Lama5 Lama2 Lama4 Tgfb1 Lamb2 Gnao1 Dner Dlk1 Dtx2 Dtx1 Mst1 Spint1 Hpn Mst1r Spint2 Ctnna1 Ppp3cb Rac1 Mapk8 F11r Pak1 Ppp3ca Pard3 Ppp3r1 Nfatc1 Prkci Wasl Lama3 Pard6a Apoa1 Apob Ptk2b Spry2 Fgfrl1 Flrt3 Flrt2 Flrt1 Mknk1 Tjp1 Tjp2 Fnta P4hb Hhat Adcy7 Ulk3 Adcy6 Spopl Dzip1 Adcy5 Adcy4 Spop Adcy3 Adcy2 Prkar2a Adcy1 Frs2 Nras Frs3 Rasgrf1 Adcy9 Psmf1 Pf4 Adcy8 Raf1 Psme4 Il5ra Fgf1 Bad Il17rd Fgf2 Cnksr1 Cnksr2 Erbb2 Fgf9 Ptk2 Fgf7 Psme3 Cdk4 Fgf6 Fgf4 Ccnd1 Fgf3 Furin Ppp5c Prkar1a Prkar1b Ranbp9 Ppp2cb Shc1 Lamtor2 Chuk Nrg2 Ppp2ca Shc3 Nrg1 Akt2 Akt3 Shc2 Psma7 Artn Nrtn Plcg1 Brap Nck2 Psmb5 Psmb4 Ubc Nrg3 Grm1 Psmb7 Nrg4 Grm5 Psmb6 Psmb2 Sharpin Psmb3 Psmb1 Nck1 Mapk3 Akt1 Mapk1 Ksr1 Ptpra Dusp16 Dusp10 Map3k11 Pip4k2b Pip4k2a Trp53 Rbck1 Pip4k2c Paqr3 Pik3ap1 Pde1c Pde1b Psme2 Pde1a Psme1 Ncam1 Sos1 Rictor Braf Psmb10 Apbb1ip Col6a1 Tas1r3 Col6a2 Ahcyl1 Tas1r2 Col6a3 Tas1r1 Col6a6 Rapgef1 Psmb11 Csf2rb2 Rapgef2 Csf2ra Mov10 Dock1 Usp8 Znrf3 Rspo2 Lgr4 Rspo4 Rspo3 Lgr6 Rhoa Rspo1 Lgr5 Elmo1 Elmo2 Arhgap35 Ptk6 Mapkapk2 Fas Casp8 Fadd Tradd Fasl Ripk1 Tnfrsf10b Tnfsf10 Kif3a Dock7 Yes1 Lyn Sh2b3 Sh2b2 Cbl Socs6 Socs1 Traf2 Nmt2 Nmt1 Ranbp10 Itgb1 Cdc37 Polr2f Polr2e Polr2h Polr2k Jup Ctnnd1 Cdh1 Cdh5 Flna Pxn Lamb3 Mapk11 Mapk13 Mapk12 Mapk14 Arhgef6 Lamc2 Ucn Acvr1b Drap1 Otulin Foxh1 Acvr2b Acvr2a Hnrnpm Hnrnpf Acvr1c Cer1 Pelp1 Camkmt Rnf146 Hnrnph1 Pygo2 Pygo1 Bcl9l Bcl9 Ucn3 Fzd9 Crhbp Fzd2 Fzd10 Fzd1 Fzd3 Adgre1 Trrap Fzd7 Ptch2 Olfr1156 Olfr1157 Olfr1052 Olfr1155 Olfr631 Olfr1357 Olfr635 Olfr1352 Olfr1162 Olfr18 Olfr1356 Fstl3 Gal Fst Gpr27 Gpr25 Olfr16 Olfr17 Rapgef4 Gpr4 Rapgef3 Oxt Olfr1093 Htr5a Npy1r Notch1 Skp1a Kiss1r Gpsm1 Olfr1094 Rho F2rl1 Grpr Ptgdr Cul1 Vrk3 Rgr Adm2 Elk1 Mef2c Mc5r Ptgfr Mef2a Dusp3 Ntsr1 Mapk7 Ntsr2 Sucnr1 Ghsr Uts2b Npy5r Uts2r Taar8b Npy4r Taar1 Taar2 Taar5 Taar6 Pnoc Taar9 Npy2r Casr Olfr231 Ptgdr2 Adora2b Trh Adora2a Opn1sw Adora3 Mc2r Adora1 Olfr919 Fshr Adrb2 Fshb C5ar1 Rhog Adrb1 Hnrnpa1 Edn1 Rhob Adrb3 Rock1 Edn3 Rhoc Edn2 Rock2 Gpha2 Memo1 Erbb2ip Mc1r Olfr222 Ptpn18 Olfr220 Ptgir Hspb1 Olfr221 Lpar5 Oxgr1 P2ry13 P2ry12 P2ry14 P2ry10 Olfr421-ps1 Matk Olfr229 Ramp1 Cul5 Brs3 Rnf41 Ccr9 Ccr8 Ccr7 Ccr6 Ccr4 Ccr3 Mc3r Calcrl Lpar6 Mc4r Ccr10 Ramp2 Ramp3 Vipr2 Olfr211 Vipr1 Cx3cl1 Ackr4 Ccl2 Ccl1 Dld Cx3cr1 Ccrl2 Vegfb Vegfc Figf Flt4 Pgf Olfr685 Scrib Olfr684 Sost Olfr683 Ccdc88c Vangl2 Reep5 Dact1 Reep4 Reep3 Nlk Pth2r Sox13 Tas2r118 Cby1 Tas2r126 Olfr410 Olfr411 Olfr412 Tas2r121 Ror1 Tas2r120 Ror2 Olfr414 Cxxc4 Reep1 Chd8 Dgkb Npff Olfr677 Dgka Pde10a Olfr1311 Olfr478 Olfr675 Olfr687 Reep2 Reep6 Tas2r119 Olfr402 Olfr681 Dgke Dgkg Iapp Gper1 Pth1r Tas2r108 Olfr175-ps1 Ccl25 Olfr821 Ccl28 Galr2 Htr2a Agtr2 Olfr32 Rab4b Htr2b Tas2r107 Htr2c Olfr1385 Rrh Sox7 Olfr419 Sox6 Rasgrp2 Wif1 Olfr417 Sox9 Olfr809 Hecw1 Olfr808 Olfr692 Sox4 Olfr691 Sox3 Olfr429 Prickle1 Olfr430 Prkg1 Olfr825 Sox17 Olfr298 Ctnnbip1 Olfr420 Klhl12 Olfr288 Ryk Agtr1a Sfrp2 Olfr832 Sfrp1 Olfr1500 Htr1d Olfr20 Olfr24 Olfr1509 Pmch Olfr1505 Htr1f Olfr57 Olfr55 Gpr18 Qrfp Hcrtr1 Ptbp1 Hcrtr2 Olfr1512 Olfr1511 Htr7 Olfr31 Galr1 Htr6 Fpr3 Olfr1102 Htr4 Olfr1100 Pomc Gpr17 Fpr2 Olfr1104 Htr1b Olfr26 Gpr15 Cdc73 Htr1a P2ry1 Rgs4 P2ry2 Rgs5 Rgs7 Rgs6 Rgs9 Rgs8 C3ar1 Gpr55 Olfr1360 Olfr618 Olfr11 Gpr20 Olfr15 Olfr13 Olfr1123 Olfr43 Olfr44 Olfr47 Olfr1396 Gast Leo1 Olfr1111 Npffr1 Cck Npffr2 Galnt3 Gpr45 Rgs1 P2ry6 Rgs2 Rgs3 P2ry4 Grp Sav1 Rtp2 Amotl2 Abhd12 Amotl1 Tbxa2r Crhr2 Crhr1 Tas2r137 Tas2r136 Tas2r135 Sst Nmb Ackr3 Tas2r131 Tas2r130 Tas2r138 Tas2r139 Grb10 Nmu Chrm3 Chrm2 Fer Ptpru Chrm1 Trhr Nms Grap Gprc6a Pik3r6 Pik3r5 Lats2 Kiss1 Chrm5 Lats1 Crh Stk3 Chrm4 Mob1a Tas2r140 Stk4 Calcr Wwc1 Tas2r144 Mob1b Gnai2 Gnai1 Olfr376 Xcr1 S1pr5 Gnai3 Olfr370 Olfr372 S1pr2 S1pr3 S1pr1 S1pr4 Sstr2 Syk Sstr1 Sh3kbp1 Opn3 Opn4 Sstr5 Npbwr1 Sstr3 Sstr4 Ppy Cort Opn5 Npb Lhcgr Npy Npw Nmbr Rtp4 Rtp3 Nps Rtp1 Olfr448 Olfr648 Pdhb Olfr447 Dlat Olfr263 Olfr444 Axin2 Olfr646 Dgkq Olfr1309 Lpar3 Lpar4 Lpar1 Lpar2 Dgkh Olfr446 Olfr267 Dgki Gcat Pdhx Olfr365 Olfr362 Pdha1 Olfr101 Ltb4r2 Olfr368 Oprd1 Ltb4r1 Olfr110 Pdyn Cxcl16 Inhba Pdk1 Cxcl13 Inhbb Pdk2 Olfr109 Pthlh Cxcl12 Pdk3 Cxcl11 Pdk4 Olfr669 Smad5 Olfr464 Zfyve16 Gpr68 Nog Gpr65 Smad6 Olfr666 Smad9 Bmpr2 Olfr870 Grem2 Olfr874 Olfr867 Fstl1 Olfr658 Olfr453 Cnr2 Abhd6 Snx3 Olfr878 Olfr243 Olfr460 Bmpr1a Olfr463 Bmpr1b Gpr83 Olfr854 Olfr272 Olfr275 Olfr270 Olfr273 Cnr1 Olfr452 Dgkz Pde11a Olfr449 Olfr640 Olfr641 Adrbk2 Gpr84 Olfr853 St3gal6 Zw10 Olfr1256 Ska1 Olfr1259 Trpc6 Ffar3 Nup85 Pde4d Pmf1 Pde4c Nup160 Olfr1258 C5ar2 Gpr150 Spc25 Olfr1193 Nudc Nts Rps27 Oprk1 Olfr1014 Spc24 Rxfp1 Xpo1 Rxfp2 Clasp2 Itgb3bp Gpbar1 Nuf2 Olfr1019 Olfr1020 Arhgef25 Rxfp4 Rxfp3 Ptprj Ptger3 Olfr1023 Ptger4 Olfr1022 Cxcl2 Ptger1 Ptger2 Olfr1029 Arf6 Olfr1032 Olfr1031 Cxcl9 Cxcl5 Wnt11 Cenpf Vip Wnt10a Ppp1cc Olfr796 Wnt3 Cenpq Grm7 Wnt10b Cenpp Grm8 Ahctf1 Wnt6 Grm2 Wnt4 Grm3 Wnt9b Itga3 Cenpm Grm4 Wnt9a Src Cenpl Hc Tns4 Cenpo Olfr504 Vps26a Lamc3 Wls Clip1 Olfr508 Cenpn Olfr1288 Tmed5 Tns3 Aurkb Wnt7a Olfr780 Wnt2b Zwilch Olfr782 Cdca8 Wnt7b Olfr786 Cenpt Olfr788 Wnt16 Apitd1 Olfr516 Gpr132 Sgol2b Olfr518 Ercc6l Prok1 Olfr1469 Mchr1 Prok2 Dsn1 Hebp1 Olfr1461 Nup107 Wnt8a Mad1l1 Olfr1264 Wnt8b Olfr1265 Wnt5b Trpc3 Olfr1451 Vps29 Wnt5a Cenph Ffar2 Wnt1 Cenpi Olfr1252 Cenpe Ffar1 Vps35 Wnt2 Cenpk Trpc7 Kif2c Olfr1006 Cxcr1 Taok1 Birc5 Daglb Tert Kif2b Olfr63 Pde7b Kif18a Olfr64 Bub1b Zwint Olfr65 Nup37 Olfr68 Prokr1 Aldh8a1 Incenp Agt Aldh1a3 Nup43 Oprl1 Crabp1 Ruvbl1 Prokr2 Nup133 Rdh13 Dagla Rcc2 Rdh14 Nsl1 Anxa1 Aldh1a2 Dhrs3 Cxcr2 Kif2a Dhrs4 Cxcr3 Ndel1 Nmur1 Spdl1 Ndc80 Nmur2 Olfr71 Cckar Kntc1 Olfr76 Bub3 Pde8a Pde8b Sdr16c5 Bub1 Olfr78 Cenpu Pth Mad2l1 Calca Casc5 Cxcr6 Olfr1008 Cenpa Olfr73 Cxcr4 Cxcr5 Cenpc1 Mgll Pde3a Frat2 Apln Tcf7l1 Olfr1046 Tle3 Aes Olfr1047 Pde2a Olfr1173 Pth2 Lef1 Olfr1034 Tcf7 Adm Gnat1 Gnat2 Gnat3 Olfr1044 Tle1 Olfr1045 Tle4 Pde4a Pde4b Tle2 Olfr96 Sgol1 Hrh3 Olfr91 Olfr95 Pyy Hrh1 Ranbp2 Hrh2 Mis12 Hrh4 Olfr66 Hcar1 Cckbr Pde7a Aplnr Olfr90 Hcar2 Oprm1 Rgs17 Rgs18 Olfr705 Olfr583 Rgs14 Olfr980 Rgs19 Olfr982 Olfr1206 Olfr589 Olfr1209 Olfr309 Gnaz Rgs10 Rgs12 Rgs11 Qrfpr Olfr3 Rbl1 Olfr314 Olfr173 Rgs21 Cdk2 E2f5 Rgs22 Olfr2 E2f4 E2f1 Rgs20 Rgs16 Olfr985 Rgs13 Olfr986 Tfdp2 Olfr310 Olfr315 Olfr984 Tfdp1 Olfr706 Olfr159 Olfr728 Olfr727 Olfr729 Olfr722 Olfr723 Olfr1414 Olfr720 Olfr1423 Olfr1425 Olfr1416 Olfr520 Olfr152 Gnal Gabbr2 Gabbr1 Olfr1408 Olfr160 Olfr305 Olfr165 Olfr164 Olfr1404 Olfr586 Olfr308 Olfr167 Olfr714 Olfr166 Olfr713 Olfr168 Olfr993 Olfr715 Olfr1204 Gm4461 Cysltr1 Adra1a Adra1b Penk Adra1d Grk6 Grk5 Mtnr1a Gpr176 Olfr1234 Mtnr1b Plcb1 Plcb2 Uts2 Hcrt Npsr1 Olfr790 Adra2a Olfr1211 Adra2c Adra2b Olfr1497 Olfr1496 Olfr1490 Olfr1494 Tacr2 Tacr3 Bdkrb1 Tacr1 Cysltr2 Bdkrb2 Kng2 Smpd3 Tshr Gnb2l1 Rgsl1 Nsmaf Olfr198 Gnrh1 Ppbp Olfr979 Olfr978 Olfr183 Olfr180 Olfr569 Olfr568 Olfr974 Olfr592 Olfr186 Olfr187 Insl5 Olfr1240 Plcb4 Plcb3 Olfr574 Olfr571 Pik3cg Insl3 Olfr577 Olfr578 Olfr576 Ppan Olfr196 Tshb Olfr193 Oxtr Os9 Derl2 Syvn1 Sel1l Poglut1 Pofut1 Olfr323 Olfr322 Olfr145 Olfr735 Olfr1426 Olfr1428 Ednra Ednrb Rln3 Rln1 Olfr1420 Olfr730 Smarca4 Olfr732 Olfr147 Olfr733 Olfr734 Olfr137 Olfr350 Myl6 Olfr745 Myh11 Olfr744 Prkcq Olfr357 Olfr749 Olfr351 Xcl1 Olfr558 Olfr557 Olfr556 Myh14 Olfr554 Olfr1434 Myh10 Olfr552 Prkch Sufu Olfr750 Limk1 Olfr125 Gli3 Arhgef11 Drd4 Limk2 Olfr348 Arhgef12 Drd5 Drd2 Drd3 Drd1 Gzmb Olfr354 Opn1mw Olfr355 Plxnb1 Tac2 Pak3 Olfr1444 Pak2 Olfr1445 Tac1 Gnrhr Myl12b Myl12a Rac2 Fes Myh9 Cdk5 Kmt2d Prlhr Xk Gpr183 Ackr1 Gpr35 Ece2 Ece1 Gpr37l1 Lppr3 Lppr2 Kel Prlh Nln Lppr1 Lppr5 Lppr4 Fgfbp3 Gpr37 Fgfbp1 Sdc3 Sdc4 Gpc6 Sdc2 Gpc3 Rab4a Sdc1 Gpc5 Gpc2 Gpc4 Ash2l Rbbp5 Hspg2 Gpc1 NEF MEDIATED CD4 DOWN-REGULATION%REACTOME%R-HSA-167590.1 Nef Mediated CD4 Down-regulation Ap2a2 Ap2m1 Lck Cd4 Arf1 Ap2b1 Ap2s1 Ap2a1 Atp6v1h SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE%REACTOME DATABASE ID RELEASE 59%416572 Sema4D induced cell migration and growth-cone collapse Limk1 Arhgef11 Limk2 Arhgef12 Rac1 Plxnb1 Rnd1 Myl12b Myl12a Myl6 Myh11 Rac2 Sema4d Rhoa Erbb2 Rhog Rhob Myh14 Myh9 Rock1 Rhoc Myh10 Rock2 TNFS BIND THEIR PHYSIOLOGICAL RECEPTORS%REACTOME%R-HSA-5669034.2 TNFs bind their physiological receptors Edar Lta Tnfrsf25 Fasl Tnfsf14 Tnfsf15 Tnfsf13 Tnfsf18 Cd70 Edaradd Tnfrsf8 Tnfrsf11b Eda Tnfsf8 Tnfsf4 Tnfsf11 Tnfrsf4 Cd27 Eda2r Tnfrsf17 Tnfrsf14 Tnfrsf1a Tnfsf13b Tnfrsf18 Tnfrsf13b Tnfrsf9 Tnfrsf1b PHASE II CONJUGATION%REACTOME DATABASE ID RELEASE 59%156580 Phase II conjugation Oplah Acsm2 Ugdh Glyatl3 Tpmt Glyat Mat2a Gstz1 Acsm5 Sult4a1 Mgst1 Ggt1 Gsta3 Trmt112 Mgst2 Mgst3 Gstt2 Gstt1 Mat2b Gss Ugt2b1 Abhd10 Gstk1 Sult1a1 Ugt1a1 Abhd14b Nnmt As3mt Nat2 Nat1 Hpgds Ugt2a3 Acsm4 Ugt2a2 Ugt2a1 Sult1b1 Acsm1 N6amt1 Slc35b2 Slc26a1 Slc26a2 Slc35b3 Papss2 Papss1 Ugt1a6a Gstm5 Gclm Gstm7 Sult2a1 Ahcy Cyp1a2 Cndp2 Gclc Sult1e1 Gstm2 Ggt6 Ggt7 Gstm4 Ugt2b38 Ugt2b36 Ugt2b34 Gstm1 Ggt5 Slc35d1 Chac2 Chac1 Ugp2 Bpnt1 Ugt1a5 Ugt1a9 Gsto1 Mtrr Gm10639 Gsto2 Ugt1a2 Akr1a1 Mat1a Ugt3a2 Mtr Comt Esd TRANSPORT OF CONNEXINS ALONG THE SECRETORY PATHWAY%REACTOME%R-HSA-190827.1 Transport of connexins along the secretory pathway Gjb1 Gjb2 Gja1 CAM-PDE 1 ACTIVATION%REACTOME%R-HSA-111957.1 Cam-PDE 1 activation Pde1c Pde1b Pde1a OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA%REACTOME%R-HSA-1234176.2 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Psmc6 Psmc5 Psmc2 Psmd2 Psmb9 Psmf1 Psmb8 Psme4 Psmc1 Psmc4 Psmc3 Psme3 Hif1a Epas1 Hif3a Ajuba Wtip Egln3 Rbx1 Limd1 Psmd12 Psma7 Psmd11 Egln2 Psmd14 Psma5 Psmb5 Cul2 Ube2d3 Psmb4 Ubc Psmd13 Psmd10 Psma4 Psmb7 Psma3 Psma6 Psmb6 Psmb2 Psmb3 Psmb1 Psma2 Psma1 Psmd9 Ube2d1 Tceb1 Psmd1 Shfm1 Psme2 Psme1 Psmd3 Psmd4 Psmb10 Psmd6 Psmd5 Vhl Psmd7 Psmb11 Psmd8 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT%REACTOME DATABASE ID RELEASE 59%72706 GTP hydrolysis and joining of the 60S ribosomal subunit Rpl39 Rplp1 Eif2s1 Eif2s2 Eif3i Eif3k Eif3l Eif3m Rpl7 Rps21 Rplp2 Rps27 Eif3a Eif3b Eif3c Rps25 Rpl4 Eif3d Rps26 Rps27l Eif3e Rpl18a Rpl34 Rpl32 Eif3f Eif3h Eif3g Rpl26 Rpl24 Rps9 Eif2s3x Rps7 Rps5 Rpsa Rpl37 Rps4x Eif4b Eif5 Eif5b Eif4a1 Eif4a2 Rpl22 Eif1ax Rpl10l Rpl23 Rpl39l Eif3j2 Rpl13a Rpl22l1 Rps15a Rpl11 Rpl17 Rps3 Rpl19 Rpl18 Rps16 Eif4e Rps14 Rps19 Rps18 Eif4h Rps11 Eif4g1 Rps10 VIRAL RNP COMPLEXES IN THE HOST CELL NUCLEUS%REACTOME DATABASE ID RELEASE 59%168330 Viral RNP Complexes in the Host Cell Nucleus Hspa1a REGULATION BY TREX1%REACTOME%R-HSA-3248023.1 Regulation by TREX1 Trex1 GAP JUNCTION DEGRADATION%REACTOME%R-HSA-190873.2 Gap junction degradation Gja1 Cltc Ap2m1 Dab2 Dnm2 Myo6 Clta Dnm1 Cltb STAT6-MEDIATED INDUCTION OF CHEMOKINES%REACTOME%R-HSA-3249367.1 STAT6-mediated induction of chemokines Tmem173 Tbk1 Stat6 CHROMATIN MODIFYING ENZYMES%REACTOME DATABASE ID RELEASE 59%3247509 Chromatin modifying enzymes Hist1h2aa Suv39h1 Atxn7 Actb Kdm4c Hist1h2af Aebp2 Nfkb2 Nfkb1 Hist3h2a Hcfc1 H2afj Hist2h2ab H2afb2 Hdac2 Taf9 Rela Hist2h2bb Hdac10 Kdm1a Hist2h2be Ep300 Hist2h2ac Hdac8 Hist1h2bg Hist1h2bh Gm10094 Tbl1x Brwd1 Hist1h2bp Hist1h2bm Ruvbl2 Ruvbl1 Hist1h2bj Hist1h2bb Rbbp7 Kdm1b Taf12 Tada3 Hist1h3d Hist1h2ak Hist1h2ag Actl6a Trrap Hist1h2ah Kdm4a Kdm4b Hist2h3c1 Sap30l Kdm7a Clock Arid4a Rest Rbbp4 Chd3 Gps2 Chd4 Brms1 Cdk4 Ccnd1 Ncor1 Ncor2 Mbd3 Arid4b Taf6l Sap130 Smarcd3 Eed Whsc1 Ehmt2 Ehmt1 Suz12 Yeats4 Ep400 Kdm6a Brpf3 Brpf1 Ing5 Hdac1 Sap30 Suds3 Dnmt3a Mta1 Kat2b Kat2a Mta3 Usp22 Prmt7 Prmt6 Pbrm1 Arid2 Smarcc2 Smarcc1 Rcor1 Actl6b Smarca4 Ezh2 Smarca2 Arid1b Arid1a Setd8 Prmt3 Wdr77 Hmg20b Kat5 Gatad2a Carm1 Gatad2b Smarcb1 Smarcd2 Smarcd1 Wdr5 Coprs Smarce1 Meaf6 Tbl1xr1 Kmt2c Atf7ip Kmt2b Kat6a Nsd1 Suv39h2 Setdb2 Smyd3 Prdm16 Setdb1 Kmt2a Kmt2d Smyd2 Padi2 Phf20 Atf2 Crebbp Hist3h2ba Tada2a Supt7l Kat7 Kat8 Kansl1 Kansl3 Hat1 Kansl2 Jak2 Yeats2 Phf2 Kdm8 Phf8 Ing4 Arid5b Mina Kdm6b Ing3 Tada1 Pax3 Mbip Mta2 Elp3 Epc1 Elp4 Elp2 Kdm5b Elp5 Elp6 Morf4l2 Prmt5 H2afz Dmap1 Morf4l1 H2afx Vps72 Prmt1 Padi6 Kdm5a Kdm5c Kdm5d Jade1 Taf5l Kdm4d Jade2 Jade3 Msl1 Padi1 Hist2h2aa1 Padi4 Ak6 Padi3 Kdm3a Msl3 Msl2 Supt20 Kdm2a Kdm2b Mrgbp Kdm3b Zzz3 Suv420h1 Csrp2bp Suv420h2 Setd1a Supt3 Setd1b Ogt Ccdc101 Dot1l Eny2 Jmjd6 Ash2l Mecom Dr1 Dpy30 Ikbkap Rbbp5 Ncoa1 Whsc1l1 Brd8 Ash1l Prdm9 Setd2 Setd3 Setd6 Ncoa2 Hdac3 Setd7 HATS ACETYLATE HISTONES%REACTOME%R-HSA-3214847.1 HATs acetylate histones Hist1h2aa Kat6a Yeats4 Atxn7 Ep400 Actb Brpf3 Hist1h2af Hist2h3c1 Brpf1 Ing5 Clock Hist3h2a Hcfc1 Hist2h2ab Phf20 Taf9 Taf6l Atf2 Hist2h2bb Crebbp Hist2h2be Hist3h2ba Ep300 Tada2a Sap130 Supt7l Hist2h2ac Kat2b Kat2a Usp22 Kat7 Hist1h2bg Kat8 Hist1h2bh Kansl1 Kansl3 Hat1 Kansl2 Yeats2 Hist1h2bp Hist1h2bm Ruvbl2 Ing4 Ruvbl1 Hist1h2bj Ing3 Tada1 Rbbp7 Hist1h2bb Pax3 Mbip Elp3 Epc1 Elp4 Elp2 Elp5 Elp6 Morf4l2 Dmap1 Morf4l1 Vps72 Taf12 Jade1 Taf5l Jade2 Jade3 Msl1 Hist2h2aa1 Ak6 Kat5 Msl3 Tada3 Msl2 Supt20 Hist1h3d Mrgbp Zzz3 Csrp2bp Supt3 Ccdc101 Hist1h2ak Ogt Eny2 Wdr5 Hist1h2ag Dr1 Ikbkap Actl6a Trrap Ncoa1 Brd8 Meaf6 Hist1h2ah Ncoa2 DAG AND IP3 SIGNALING%REACTOME%R-HSA-1489509.2 DAG and IP3 signaling Adcy7 Adcy6 Prkcd Adcy5 Prkce Adcy4 Adcy3 Adcy2 Prkar2a Prkcg Adcy1 Prkacb Adcy9 Plcg1 Adcy8 Prkca Prkar2b Adrbk1 Creb1 Pde1c Camk4 Pde1b Pde1a Itpr1 Prkar1a Prkar1b Ahcyl1 Prkaca Itpr3 Itpr2 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE%REACTOME DATABASE ID RELEASE 59%1799339 SRP-dependent cotranslational protein targeting to membrane Rpl39 Rplp1 Rpl7 Rps21 Rps27 Rplp2 Rps25 Rpl4 Tram1 Rps26 Rps27l Rpl18a Rpl34 Rpl32 Srp72 Rpl26 Ddost Rpl24 Rps9 Rps7 Rps5 Srp68 Sec11c Sec11a Srp14 Spcs1 Rpsa Spcs2 Rpl37 Spcs3 Rps4x Srp19 Rpn2 Sec61a2 Sec61g Sec61a1 Sec61b Srprb Ssr1 Srp9 Srpr Rpn1 Srp54a Rpl22 Rpl10l Rpl23 Rpl39l Ssr2 Rpl13a Rpl22l1 Ssr3 Rps15a Ssr4 Rpl11 Rpl17 Rps3 Rpl19 Rpl18 Rps16 Rps14 Rps19 Rps18 Rps11 Rps10 POTASSIUM TRANSPORT CHANNELS%REACTOME DATABASE ID RELEASE 59%1296067 Potassium transport channels Kcnj1 Kcnj10 Kcnj16 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM%REACTOME%R-HSA-196741.2 Cobalamin (Cbl, vitamin B12) transport and metabolism Mmachc Gif Lmbrd1 Amn Abcc1 Mut Mtrr Cd320 Cubn Mmadhc Mmaa Tcn2 Ctrb1 Mtr Prss2 Abcd4 Mmab Ctrc NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING%REACTOME%R-HSA-936440.1 Negative regulators of RIG-I MDA5 signaling Rnf135 Tbk1 Atg5 Tnfaip3 Isg15 Ube2l6 Irf3 Trim25 Mavs Ube2d3 Ikbke Tax1bp1 Traf3 Ubc Itch Ifih1 Cyld Pin1 Ube2d1 Nlrx1 Ube2k Uba7 Atg12 Pcbp2 Ddx58 Otud5 Rnf216 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY%REACTOME DATABASE ID RELEASE 59%918233 TRAF3-dependent IRF activation pathway Irf7 Rnf135 Sike1 Tbk1 Irf3 Trim25 Ikbke Crebbp Mavs Traf3 Ifih1 Ep300 Ddx58 Ifnb1 TRAF6 MEDIATED IRF7 ACTIVATION%REACTOME DATABASE ID RELEASE 59%933541 TRAF6 mediated IRF7 activation Irf7 Rnf135 Irf1 Sike1 Tbk1 Traf6 Dhx36 Irf2 Irf3 Trim25 Mavs Ikbke Crebbp Tank Ifih1 Ep300 Traf2 Myd88 Ddx58 Ifnb1 Ifna16 RET SIGNALING%REACTOME%R-HSA-8853659.3 RET signaling Akap9 Rap1gap Ppp2r1a Dok1 Dok2 Csf2 Jak1 Dok5 Dok6 Dok4 Frs2 Nras Frs3 Rasgrf1 Psmf1 Raf1 Psme4 Il5ra Fgf1 Il17rd Fgf2 Cnksr1 Csk Cnksr2 Erbb2 Fgf9 Ptk2 Fgf7 Psme3 Fgf6 Fgf4 Fgf3 Mapk7 Shank3 Ppp5c Ranbp9 Ppp2cb Shc1 Lamtor2 Nrg2 Ppp2ca Shc3 Nrg1 Shc2 Psma7 Artn Nrtn Plcg1 Brap Gab2 Psmb5 Psmb4 Ubc Nrg3 Psmb7 Nrg4 Psmb6 Psmb2 Psmb3 Psmb1 Mapk3 Mapk1 Ksr1 Ptpra Dusp16 Dusp10 Map3k11 Paqr3 Psme2 Psme1 Ncam1 Sos1 Braf Psmb10 Apbb1ip Psmb11 Csf2rb2 Rapgef2 Csf2ra Grb7 Actn2 Nf1 Pdgfrb Pdgfra Kbtbd7 Prkca Il2rg Arrb2 Egfr Gab1 Arrb1 Ret Vwf Sptan1 Pspn Map2k1 Rbx1 Fgg Map2k2 Cul3 Psmd12 Pdgfb Psmd11 Rasgef1a Psmd14 Rasa3 Rasa4 Psmd13 Psmd10 Il2 Rasa2 Rasa1 Nefl Spred3 Kit Spred2 Grin2a Spred1 Spta1 Il5 Sptbn4 Ppp2r1b Ywhab Kras Gdnf Shfm1 Irs2 Syngap1 Hbegf Irs1 Il3ra Btc Il2ra Il2rb Angpt1 Ptpn11 Psmc6 Egf Fgf23 Psmc5 Fgf22 Mark3 Psmc2 Fgf20 Psmd2 Dab2ip Prkacb Tek Psmb9 Psmb8 Araf Hras Grin1 Grb10 Ppp2r5e Dlg4 Ppp2r5c Ppp2r5d Ppp2r5a Psmc1 Psmc4 Psmc3 Pik3cb Sptbn2 Pik3cd Sptbn1 Itgb3 Fyn Phb Grin2c Rasgrp4 Rasgrp3 Pebp1 Ppp2r5b Rasgrp1 Tln1 Pik3ca Fga Fgb Grin2d Prkaca Grin2b Sptb Hgf Gfra2 Gfra3 Gfra4 Ereg Jak2 Pea15a Itga2b Rap1a Jak3 Wdr83 Camk2d Rap1b Camk2a Fgfr4 Camk2b Psma5 Rasal3 Rasal2 Psma4 Psma3 Psma6 Vcl Camk2g Psma2 Psma1 Gfra1 Psmd9 Dusp7 Iqgap1 Fgf16 Dusp6 Dusp9 Fgf15 Dusp8 Klb Fgf18 Psmd1 Met Fn1 Rasal1 Dusp1 Psmd3 Psmd4 Psmd6 Psmd5 Dusp2 Pik3r3 Psmd7 Pik3r1 Dusp5 Psmd8 Fgf10 Pik3r2 Dusp4 PROTEIN REPAIR%REACTOME DATABASE ID RELEASE 59%5676934 Protein repair Pcmt1 Msrb3 Txn1 Msra Msrb2 Msrb1 TRANSLESION SYNTHESIS BY REV1%REACTOME DATABASE ID RELEASE 59%110312 Translesion synthesis by REV1 Rev1 Pcna Rfc5 Mad2l2 Rpa2 Rpa1 Ubc Rfc3 Rfc2 Rpa3 Rfc4 Rfc1 Rev3l COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING%REACTOME DATABASE ID RELEASE 59%389958 Cooperation of Prefoldin and TriC CCT in actin and tubulin folding Cct5 Tcp1 Tubb6 Cct8 Cct4 Vbp1 Cct7 Tubb3 Tuba1a Tubb1 Actb Tubb2b Tubal3 Tubb2a Tuba8 Pfdn2 Tuba3b Tuba1b Pfdn6 Tuba1c Pfdn1 Pfdn4 Pfdn5 Tubb4a Cct2 Tubb4b Cct6b Cct3 Tuba4a DEFECTIVE SLCO1B1 CAUSES HYPERBILIRUBINEMIA, ROTOR TYPE (HBLRR)%REACTOME%R-HSA-5619110.1 Defective SLCO1B1 causes hyperbilirubinemia, Rotor type (HBLRR) Alb P2Y RECEPTORS%REACTOME%R-HSA-417957.1 P2Y receptors P2ry1 P2ry2 P2ry13 Lpar6 P2ry12 Lpar4 Gpr17 P2ry14 P2ry10 Ppan P2ry6 P2ry4 ACETYLCHOLINE REGULATES INSULIN SECRETION%REACTOME%R-HSA-399997.1 Acetylcholine regulates insulin secretion Chrm3 Plcb3 Marcks Gna11 Gnaq Plcb1 Gna15 Plcb2 Gna14 Prkca CDO IN MYOGENESIS%REACTOME DATABASE ID RELEASE 59%375170 CDO in myogenesis Cdh2 Ctnnb1 Mef2b Cdh4 Tcf4 Neo1 Myog Tcf3 Ctnna2 Myf5 Mef2c Mef2a Ctnna1 Map2k6 Spag9 Tbc1d24 Mef2d Bnip2 Tcf12 Myf6 Cdon Myod1 Mapk11 Mapk12 Mapk14 Cdh15 Abl1 HISTAMINE RECEPTORS%REACTOME DATABASE ID RELEASE 59%390650 Histamine receptors Hrh3 Hrh1 Hrh2 Hrh4 RELEASE%REACTOME DATABASE ID RELEASE 59%168298 Release METABOLISM OF INGESTED H2SEO4 AND H2SEO3 INTO H2SE%REACTOME DATABASE ID RELEASE 59%2408550 Metabolism of ingested H2SeO4 and H2SeO3 into H2Se Papss2 Papss1 Txnrd1 FRS-MEDIATED FGFR2 SIGNALING%REACTOME DATABASE ID RELEASE 59%5654700 FRS-mediated FGFR2 signaling Fgf23 Fgf16 Fgf22 Kras Fgf20 Frs2 Nras Fgf18 Frs3 Hras Sos1 Fgf1 Fgf2 Fgf9 Fgf7 Ptpn11 Fgf6 Fgf10 Fgf4 Fgf3 KANDUTSCH-RUSSELL PATHWAY%REACTOME DATABASE ID RELEASE 59%6807062 Kandutsch-Russell pathway Dhcr7 Dhcr24 Ebp Sc5d SYNTHESIS OF 5-EICOSATETRAENOIC ACIDS%REACTOME DATABASE ID RELEASE 59%2142688 Synthesis of 5-eicosatetraenoic acids Alox5 Gpx2 Alox5ap Pon2 Pon1 Gpx1 Ltc4s Gpx4 Pon3 INHIBITION OF PKR%REACTOME%R-HSA-169131.3 Inhibition of PKR Eif2ak2 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S%REACTOME%R-HSA-72662.2 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Eif2s1 Eif2s2 Eif3i Eif3k Eif3l Eif3m Rps21 Rps27 Eif3a Eif3b Eif4b Eif3c Rps25 Eif3d Rps26 Rps27l Eif3e Eif3f Eif3h Eif3g Rps9 Eif2s3x Rps7 Rps5 Eif4a1 Eif4a2 Eif1ax Eif3j2 Rps15a Rps3 Rps16 Eif4e Rps14 Rps19 Rps18 Eif4h Pabpc1 Rps11 Eif4g1 Rps10 Eif4ebp1 Rpsa Rps4x GRB7 EVENTS IN ERBB2 SIGNALING%REACTOME DATABASE ID RELEASE 59%1306955 GRB7 events in ERBB2 signaling Grb7 Nrg2 Nrg1 Erbb2 G1 S TRANSITION%REACTOME%R-HSA-69206.2 G1 S Transition Ppp2r1a Rb1 Mcm6 Ccne1 Mcm3 Mcm2 Mcm5 Ccne2 Mcm4 Ptk6 Orc4 Orc5 Mcm8 Mcm7 Pole Mnat1 Fbxo5 Cdt1 Cdc45 Orc2 Orc3 Orc6 Orc1 Prim1 Pole2 Rpa2 Rpa1 Rpa3 Pola1 Pola2 Pole4 Prim2 Pole3 Cdkn1a Psmd12 Psmd11 Psmd14 Psmd13 Psmd10 Ppp2r1b Shfm1 Psmc6 Psmc5 Psmc2 Psmd2 Pcna Psmb9 Psmf1 Psmb8 Cdc6 Cdk2 Cdk1 Skp1a E2f1 Psmc1 Rrm2 Ccna1 Psmc4 Tyms Psmc3 Dhfr Skp2 Cdc25a Tk2 Ccna2 Cul1 Cdk4 Tfdp2 Psme3 Cks1b Max Tfdp1 Ccnd1 Cdkn1b Ppp2cb Wee1 Ppp2ca Akt2 Akt3 Psma7 Psma5 Psmb5 Psmb4 Ubc Psma4 Psma3 Psmb7 Myc Psma6 Psmb6 Cdc7 Psmb2 Psmb3 Psma2 Dbf4 Psmb1 Psma1 Mcm10 Akt1 Psmd9 Psmd1 Psme2 Psme1 Psmd3 Psmd4 Ccnh Psmb10 Psmd6 Psmd5 Cdk7 Psmd7 Psmd8 SYNTHESIS OF DOLICHYL-PHOSPHATE MANNOSE%REACTOME%R-HSA-162699.1 Synthesis of dolichyl-phosphate mannose Dpm1 Dpm2 Dpm3 LISTERIA MONOCYTOGENES ENTRY INTO HOST CELLS%REACTOME%R-HSA-8876384.1 Listeria monocytogenes entry into host cells Ctnnd1 Cdh1 Cbll1 Ctnnb1 Src Met Sh3kbp1 Ubc Cbl Sh3gl2 Sh3gl1 Stam Hgs Stam2 Eps15 MET RECEPTOR ACTIVATION%REACTOME DATABASE ID RELEASE 59%6806942 MET Receptor Activation Hgfac Spint1 Hpn Spint2 Met Hgf UBIQUINOL BIOSYNTHESIS%REACTOME%R-HSA-2142789.1 Ubiquinol biosynthesis Pdss1 Pdss2 Coq2 Coq6 Coq5 Coq9 Coq7 Coq3 MITOCHONDRIAL BIOGENESIS%REACTOME DATABASE ID RELEASE 59%1592230 Mitochondrial biogenesis Prkag2 Prkag1 Prkag3 Prkaa2 Helz2 Nrf1 Chd9 Atp5b Alas1 Mef2c Hcfc1 Creb1 Esrra Ncor1 Tfam Crtc1 Mef2d Atf2 Mterf1b Crebbp Ssbp1 Gabpa Sirt3 Smarcd3 Polg2 Crtc3 Crtc2 Peo1 Pprc1 Nr1d1 Med1 Tbl1x Ppara Tfb1m Polrmt Ppargc1b Ppargc1a Prkab1 Prkab2 Rxra Tfb2m Carm1 Mapk11 Mapk12 Mapk14 Ncoa1 Ncoa6 Ncoa2 Tbl1xr1 Hdac3 CHOLINE CATABOLISM%REACTOME%R-HSA-6798163.1 Choline catabolism Sardh Aldh7a1 Bhmt Slc44a1 Dmgdh Chdh SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS%REACTOME DATABASE ID RELEASE 59%446219 Synthesis of substrates in N-glycan biosythesis St6galnac6 St6galnac5 St6galnac4 St6galnac3 St6gal2 Uap1 Nagk Fuk Neu1 Neu3 Neu2 Neu4 Gmppa Gmppb Dpm1 Cmas Dpm2 Nus1 Dpm3 Slc17a5 Gne Npl Amdhd2 Nans Nanp St6gal1 Tsta3 Dolpp1 Dolk Dhdds St8sia3 Gmds Fuom St8sia2 St8sia6 Gfpt1 Renbp St3gal4 Mpi Ctsa Pgm3 St6galnac1 Srd5a3 St6galnac2 Fpgt Glb1 Gfpt2 St8sia1 Slc35a1 St3gal1 St3gal2 Slc35c1 Pmm2 St8sia5 Pmm1 St8sia4 Gnpnat1 Mvd Nudt14 St3gal5 Alg5 St3gal6 REGULATION OF THYROID HORMONE ACTIVITY%REACTOME DATABASE ID RELEASE 59%350864 Regulation of thyroid hormone activity Dio3 Dio2 Dio1 LOSS OF FUNCTION OF SMAD2 3 IN CANCER%REACTOME%R-HSA-3304349.1 Loss of Function of SMAD2 3 in Cancer Tgfbr1 Tgfb1 Tgfbr2 Smad4 Smad2 Smad3 NETRIN-1 SIGNALING%REACTOME%R-HSA-373752.1 Netrin-1 signaling Trpc6 Dock1 Trpc4 Siah1a Trpc5 Neo1 Slit2 Plcg1 Prkcq Ntn1 Ptk2 Siah2 Nck1 Fyn Trpc1 Rac1 Myo10 Ntn4 Unc5b Slit1 Slit3 Hfe2 Rgma Rgmb Agap2 Ablim3 Unc5a Ablim2 Ezr Ablim1 Robo1 Wasl Trio Trpc3 Dcc Unc5c Pitpna Ptpn11 Unc5d Trpc7 OTHER SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 59%416700 Other semaphorin interactions Ptprc Itgb1 Plxnd1 Plxnc1 Sema5a Trem2 Plxnb3 Sema6a Plxna2 Sema6d Tyrobp Sema3e Sema4a Sema4d Itga1 Sema7a Plxna4 Cd72 Plxna1 PHOSPHOLIPASE C-MEDIATED CASCADE: FGFR1%REACTOME DATABASE ID RELEASE 59%5654219 Phospholipase C-mediated cascade: FGFR1 Fgf1 Fgf23 Fgf22 Fgf2 Fgf20 Fgf9 Fgf10 Fgf6 Fgf4 Plcg1 Fgf3 HDMS DEMETHYLATE HISTONES%REACTOME%R-HSA-3214842.3 HDMs demethylate histones Phf2 Kdm8 Kdm4a Kdm6a Phf8 Arid5b Kdm4b Kdm4c Kdm6b Mina Kdm1b Hist2h3c1 Kdm5b Kdm7a Kdm5a Kdm5c Kdm5d Kdm4d Kdm3a Hist1h3d Kdm2a Kdm2b Kdm3b Kdm1a Jmjd6 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1%REACTOME DATABASE ID RELEASE 59%1810476 RIP-mediated NFkB activation via ZBP1 Ripk3 Chuk App Ripk1 Ticam1 Ikbkb Ager Tlr3 Ikbkg Rela Nfkb2 Nfkbia Nfkb1 Nfkbib Saa3 Myd88 Dhx9 S100b Zbp1 PI-3K CASCADE:FGFR4%REACTOME DATABASE ID RELEASE 59%5654720 PI-3K cascade:FGFR4 Fgf23 Fgf16 Fgf15 Fgf20 Frs2 Klb Fgf18 Fgfr4 Pik3ca Fgf1 Gab1 Fgf2 Fgf9 Pik3r1 Ptpn11 Fgf6 Fgf4 FCERI MEDIATED MAPK ACTIVATION%REACTOME DATABASE ID RELEASE 59%2871796 FCERI mediated MAPK activation Akap9 Ppp2r1a Mapk9 Mapk10 Rac1 Jun Mapk8 Map3k1 Pak1 Map2k7 Map2k4 Csf2 Jak1 Vav2 Frs2 Nras Frs3 Rasgrf1 Psmf1 Raf1 Psme4 Il5ra Fgf1 Il17rd Fgf2 Cnksr1 Csk Cnksr2 Erbb2 Fgf9 Ptk2 Fgf7 Psme3 Fgf6 Fgf4 Fgf3 Ppp5c Ranbp9 Ppp2cb Shc1 Lamtor2 Nrg2 Ppp2ca Shc3 Nrg1 Shc2 Psma7 Artn Nrtn Plcg1 Brap Psmb5 Psmb4 Ubc Nrg3 Psmb7 Nrg4 Psmb6 Psmb2 Psmb3 Psmb1 Mapk3 Mapk1 Ksr1 Ptpra Dusp16 Dusp10 Map3k11 Paqr3 Psme2 Psme1 Ncam1 Sos1 Braf Psmb10 Apbb1ip Psmb11 Csf2rb2 Rapgef2 Grap2 Csf2ra Lcp2 Actn2 Nf1 Pdgfrb Pdgfra Kbtbd7 Vav1 Il2rg Arrb2 Egfr Arrb1 Ret Vwf Sptan1 Pspn Map2k1 Rbx1 Fgg Map2k2 Cul3 Psmd12 Pdgfb Psmd11 Rasgef1a Psmd14 Lyn Rasa3 Rasa4 Psmd13 Psmd10 Il2 Rasa2 Rasa1 Nefl Spred3 Kit Spred2 Grin2a Spred1 Spta1 Il5 Sptbn4 Ppp2r1b Ywhab Kras Gdnf Shfm1 Pak2 Irs2 Syngap1 Hbegf Irs1 Il3ra Btc Il2ra Il2rb Angpt1 Psmc6 Egf Fgf23 Psmc5 Fgf22 Mark3 Psmc2 Fgf20 Psmd2 Dab2ip Tek Psmb9 Psmb8 Araf Hras Grin1 Ppp2r5e Dlg4 Ppp2r5c Ppp2r5d Ppp2r5a Psmc1 Psmc4 Psmc3 Sptbn2 Sptbn1 Itgb3 Fyn Phb Grin2c Rasgrp4 Rasgrp3 Plcg2 Pebp1 Ppp2r5b Rasgrp1 Syk Tln1 Fga Fos Fgb Grin2d Grin2b Sptb Vav3 Hgf Gfra2 Gfra3 Gfra4 Ereg Jak2 Pea15a Itga2b Rap1a Jak3 Wdr83 Camk2d Rap1b Camk2a Fgfr4 Camk2b Psma5 Rasal3 Rasal2 Psma4 Psma3 Psma6 Vcl Camk2g Psma2 Psma1 Gfra1 Psmd9 Dusp7 Iqgap1 Fgf16 Dusp6 Dusp9 Fgf15 Dusp8 Klb Fgf18 Psmd1 Met Fn1 Rasal1 Dusp1 Psmd3 Psmd4 Psmd6 Psmd5 Dusp2 Psmd7 Dusp5 Psmd8 Fgf10 Dusp4 GDP-FUCOSE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 59%6787639 GDP-fucose biosynthesis Fpgt Slc35c1 Fuk Gmds Fuom Tsta3 MAPK FAMILY SIGNALING CASCADES%REACTOME%R-HSA-5683057.2 MAPK family signaling cascades Cdc42ep3 Cdc42ep5 Etv4 Akap9 Sept7 Ppp2r1a Xpo1 Cdc42ep2 Cdc14b Mapk4 Mapk6 Dnajb1 Rac1 Jun Pak1 Il6 Csf2 Ncoa3 Jak1 Tyk2 Frs2 Nras Frs3 Rasgrf1 Psmf1 Raf1 Psme4 Il5ra Fgf1 Il17rd Fgf2 Cnksr1 Csk Cnksr2 Erbb2 Fgf9 Ptk2 Fgf7 Psme3 Fgf6 Fgf4 Fgf3 Ppp5c Ranbp9 Ppp2cb Shc1 Lamtor2 Nrg2 Hspb1 Ppp2ca Shc3 Nrg1 Shc2 Psma7 Artn Nrtn Brap Psmb5 Psmb4 Ubc Nrg3 Psmb7 Myc Nrg4 Psmb6 Psmb2 Psmb3 Psmb1 Mapk3 Mapk1 Ksr1 Ptpra Il6ra Dusp16 Dusp10 Map3k11 Paqr3 Psme2 Psme1 Ncam1 Sos1 Braf Psmb10 Apbb1ip Psmb11 Csf2rb2 Rapgef2 Csf2ra Mov10 Igf2bp1 Actn2 Nf1 Pdgfrb Pdgfra Kbtbd7 Il2rg Arrb2 Egfr Arrb1 Ret Vwf Ccnd3 Sptan1 Pspn Map2k1 Rbx1 Fgg Map2k2 Cul3 Psmd12 Pdgfb Psmd11 Rasgef1a Psmd14 Rasa3 Rasa4 Psmd13 Psmd10 Il2 Rasa2 Rasa1 Nefl Spred3 Kit Spred2 Grin2a Spred1 Spta1 Il5 Sptbn4 Ppp2r1b Ywhab Ago2 Ago1 Tnrc6c Cdc14a Kras Tnrc6b Gdnf Pak3 Shfm1 Pak2 Tnrc6a Ago4 Ago3 Irs2 Syngap1 Hbegf Irs1 Il3ra Btc Il2ra Il2rb Angpt1 Ptpn11 Psmc6 Egf Fgf23 Psmc5 Fgf22 Mark3 Psmc2 Fgf20 Psmd2 Dab2ip Prkacb Tek Psmb9 Psmb8 Mapkapk5 Araf Hras Grin1 Ppp2r5e Dlg4 Cdk1 Ppp2r5c Ppp2r5d Ppp2r5a Psmc1 Psmc4 Psmc3 Foxo3 Sptbn2 Foxo1 Sptbn1 Itgb3 Fyn Phb Grin2c Rasgrp4 Rasgrp3 Pebp1 Ppp2r5b Rasgrp1 Tln1 Fga Fgb Grin2d Prkaca Grin2b Sptb Hgf Gfra2 Gfra3 Gfra4 Ereg Jak2 Pea15a Itga2b Rap1a Jak3 Wdr83 Camk2d Rap1b Camk2a Fgfr4 Camk2b Psma5 Rasal3 Rasal2 Psma4 Psma3 Rag2 Psma6 Rag1 Vcl Camk2g Psma2 Psma1 Gfra1 Psmd9 Dusp7 Iqgap1 Fgf16 Dusp6 Dusp9 Fgf15 Dusp8 Klb Kalrn Fgf18 Psmd1 Met Fn1 Rasal1 Dusp1 Psmd3 Psmd4 Psmd6 Psmd5 Dusp2 Psmd7 Dusp5 Psmd8 Fgf10 Dusp4 LYSOSOMAL GLYCOGEN CATABOLISM%REACTOME DATABASE ID RELEASE 59%5357572 Lysosomal glycogen catabolism Gyg Gaa TWIK-RELEATED ACID-SENSITIVE K+ CHANNEL (TASK)%REACTOME DATABASE ID RELEASE 59%1299316 TWIK-releated acid-sensitive K+ channel (TASK) Kcnk9 Kcnk3 SIGNALING BY FGFR%REACTOME%R-HSA-190236.1 Signaling by FGFR Fgf23 Fgf22 Rbfox2 Fgf20 Frs2 Nras Ppp2r1a Frs3 Esrp2 Tia1 Hras Tial1 Fgf1 Gab1 Fgf2 Fgf9 Hnrnpm Hnrnpf Fgf7 Fgf6 Fgf4 Fgf3 Polr2f Polr2i Polr2e Polr2j Polr2h Polr2c Polr2d Polr2b Polr2g Polr2k Pik3ca Polr2a Fgfbp3 Hnrnpa1 Gtf2f1 Ncbp1 Fgfbp1 Ncbp2 Gtf2f2 Ppp2cb Spry2 Fgfrl1 Flrt3 Ppp2ca Flrt2 Flrt1 Ptbp1 Fgfr4 Plcg1 Mknk1 Ubc Cbl Spred2 Mapk3 Mapk1 Spred1 Hnrnph1 Fgf16 Fgf15 Kras Klb Fgf18 Sos1 Braf Galnt3 Pik3r1 Ptpn11 Fgf10 TRANSCRIPTION-COUPLED NUCLEOTIDE EXCISION REPAIR (TC-NER)%REACTOME DATABASE ID RELEASE 59%6781827 Transcription-Coupled Nucleotide Excision Repair (TC-NER) Ppie Lig3 Pcna Ddb1 Ercc6 Polk Rfc5 Rfc3 Rfc2 Rfc4 Rfc1 Polr2f Polr2i Polr2e Polr2j Polr2h Mnat1 Pole Ell Polr2c Polr2d Polr2b Pold1 Pold2 Isy1 Pold3 Pold4 Polr2g Polr2k Xpa Pole2 Rpa2 Ercc5 Cul4a Rpa1 Usp7 Ep300 Rpa3 Polr2a Xab2 Lig1 Ercc4 Gtf2h1 Pole4 Ercc1 Cul4b Gtf2h2 Pole3 Gtf2h5 Gtf2h4 Rbx1 Ercc8 Prpf19 Zfp830 Gtf2h3 Ercc3 Ubc Ercc2 Cops7b Cops7a Tcea1 Xrcc1 Aqr Uvssa Cops8 Cops6 Ccnh Cops2 Cops4 Cops5 Cops3 Cdk7 MITOCHONDRIAL FATTY ACID BETA-OXIDATION%REACTOME%R-HSA-77289.4 Mitochondrial Fatty Acid Beta-Oxidation Acadl Acadvl Eci1 Mcat Mcee Decr1 Echs1 Mut Acsm3 Hadhb Acadm Pcca Mmaa Hadha Hadh Ndufab1 Acad12 Pccb Acad10 Acads Acad11 Acaa2 REGULATION OF GAP JUNCTION ACTIVITY%REACTOME DATABASE ID RELEASE 59%191650 Regulation of gap junction activity Gja1 Tjp1 ROLE OF ABL IN ROBO-SLIT SIGNALING%REACTOME DATABASE ID RELEASE 59%428890 Role of Abl in Robo-Slit signaling Robo1 Clasp1 Cap1 Abl1 Clasp2 Slit2 Abl2 Gpc1 Cap2 REGULATION OF TNFR1 SIGNALING%REACTOME%R-HSA-5357905.2 Regulation of TNFR1 signaling Casp8 Tnf Tradd Chuk Ripk1 Tnfaip3 Usp21 Xiap Tax1bp1 Ubc Otud7b Otulin Usp2 Clip3 Usp4 Traf1 Cyld Traf2 Sharpin Gnb2l1 Birc3 Birc2 Ikbkb Rbck1 Sppl2a Sppl2b Rnf31 Ikbkg Tnfrsf1a INTERLEUKIN-1 PROCESSING%REACTOME%R-HSA-448706.1 Interleukin-1 processing Nfkb2 Nfkb1 Casp1 Il1b Il1a Il18 Rela FORMATION OF FIBRIN CLOT (CLOTTING CASCADE)%REACTOME%R-HSA-140877.2 Formation of Fibrin Clot (Clotting Cascade) F13a1 Procr Gp1bb F10 Gp1ba Pros1 Fgg Thbd Prtn3 Serpine2 F13b Cd177 Gp5 Pf4 Gp9 Serpina5 Proc Serpind1 Serpinc1 Vwf Kng2 F3 C1qbp F12 Tfpi Serping1 F11 Prcp F5 F8 Klkb1 A2m Fga Fgb F2r F2 F9 F7 DEFECTIVE B3GAT3 CAUSES JDSSDHD%REACTOME DATABASE ID RELEASE 59%3560801 Defective B3GAT3 causes JDSSDHD Agrn Sdc3 Sdc4 Gpc6 Bgn Sdc2 Dcn Gpc3 Sdc1 Gpc5 Bcan Gpc2 Gpc4 Cspg4 Cspg5 Ncan Vcan Hspg2 Gpc1 BIOSYNTHESIS OF A2E, IMPLICATED IN RETINAL DEGRADATION%REACTOME DATABASE ID RELEASE 59%2466712 Biosynthesis of A2E, implicated in retinal degradation Napepld TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION%REACTOME%R-HSA-1474151.2 Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation Gchfr Prkg2 Pts Dhfr Nos3 Spr Gch1 Hsp90aa1 Akt1 KERATAN SULFATE BIOSYNTHESIS%REACTOME%R-HSA-2022854.1 Keratan sulfate biosynthesis Lum Chst2 St3gal4 Chst5 Chst1 B4gat1 Fmod B4galt3 B3gnt3 St3gal1 B3gnt2 St3gal2 B4galt1 B3gnt7 B4galt5 Omd Prelp B4galt4 B3gnt4 B4galt6 Kera Ogn Slc35d2 B4galt2 St3gal6 CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 59%446728 Cell junction organization Cldn6 Cd151 Itgb4 Itga6 Itgb1 Cldn9 Cldn3 Cldn4 Cldn5 Ctnna1 Rsu1 Cadm2 Cadm1 Lims2 Ilk F11r Pard3 Crb3 Actn1 Cdh24 Prkci Col17a1 Tesk1 Lama3 Pard6b Fermt2 Pard6a Parvb Pard6g Parva Cadm3 Jup Ctnnd1 Cdh1 Cdh2 Cdh3 Cldn2 Cldn1 Cdh4 Cdh5 Cdh6 Cdh8 Flnc Cdh7 Flna Cdh9 Pxn Cldn23 Fblim1 Cldn22 Cldn20 Ang Inadl Cldn19 Cldn17 Plec Pvrl4 Cldn18 Pvrl1 Pvrl2 Lamb3 Cldn16 Cldn10 Cldn15 Pvrl3 Cldn11 Cldn14 Cldn12 Vasp Cdh17 Cdh10 Cdh13 Cdh12 Cdh15 Arhgef6 Mpp5 Cdh11 Cldn8 Cldn7 Lamc2 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER%REACTOME%R-HSA-2173793.2 Transcriptional activity of SMAD2 SMAD3:SMAD4 heterotrimer Ppm1a Serpine1 Usp9x Cdk9 Cdk8 Ccnc Skil Sp1 Rbl1 Ube2d3 Parp1 Ubc E2f5 Myc E2f4 Hdac1 Atp1b4 Wwtr1 Tgif2 Tgif1 Tfdp2 Cdkn2b Rnf111 Tfdp1 Ski Ube2d1 Ncor1 Junb Smad4 Ncor2 Smad2 Smad7 Smad3 Ccnt1 Trim33 Nedd4l Ccnk Men1 Smurf2 Ccnt2 SODIUM-COUPLED SULPHATE, DI- AND TRI-CARBOXYLATE TRANSPORTERS%REACTOME DATABASE ID RELEASE 59%433137 Sodium-coupled sulphate, di- and tri-carboxylate transporters Slc13a5 Slc13a3 Slc13a1 Slc13a2 Slc13a4 INTERACTION BETWEEN L1 AND ANKYRINS%REACTOME%R-HSA-445095.1 Interaction between L1 and Ankyrins Scn2a1 Scn5a Scn9a Kcnq3 Ank1 Ank3 Nfasc Kcnq2 Scn2b Scn10a Sptbn2 Spta1 Sptbn1 Sptbn4 Scn3a Scn3b Scn11a L1cam Sptan1 Scn7a Scn1a Scn8a Scn1b Scn4b Nrcam Scn4a Sptb ENOS ACTIVATION%REACTOME DATABASE ID RELEASE 59%203615 eNOS activation Cygb Lypla1 Zdhhc21 Nos3 Ddah2 Ddah1 Cav1 Hsp90aa1 Akt1 CONJUGATION OF BENZOATE WITH GLYCINE%REACTOME DATABASE ID RELEASE 59%177135 Conjugation of benzoate with glycine Glyatl3 Acsm1 Glyat IRAK1 RECRUITS IKK COMPLEX%REACTOME DATABASE ID RELEASE 59%937039 IRAK1 recruits IKK complex Peli1 Chuk Irak1 Peli3 Traf6 Ikbkb Peli2 Ube2v1 Ube2n Ikbkg FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC%REACTOME%R-HSA-389960.1 Formation of tubulin folding intermediates by CCT TriC Tubb4a Cct2 Cct5 Tubb4b Tcp1 Cct6b Cct8 Tubb6 Cct3 Cct4 Cct7 Tubb3 Tubb1 Tuba1a Tuba4a Tubb2b Tubal3 Tubb2a Tuba8 Tuba1b Tuba3b Tuba1c RHO GTPASES ACTIVATE IQGAPS%REACTOME DATABASE ID RELEASE 59%5626467 RHO GTPases activate IQGAPs Ctnna1 Iqgap1 Cdh1 Iqgap3 Iqgap2 Rac1 Ctnnb1 Men1 Clip1 SCAVENGING OF HEME FROM PLASMA%REACTOME%R-HSA-2168880.1 Scavenging of heme from plasma Jchain Ambp Alb Cd163 Hpx Hp Lrp1 Hba-a1 Hbb-bt Hbb-bs Apoa1 PROCESSING OF CAPPED INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 59%75067 Processing of Capped Intronless Pre-mRNA Nudt21 Cstf2t Pabpn1 Fip1l1 Cstf3 Sympk Cstf2 Zfp473 Cpsf3 Cpsf2 Cpsf4 Cpsf7 Lsm11 Cpsf1 Cstf1 Clp1 Papola Wdr33 Lsm10 Ncbp1 Snrpb Ncbp2 Snrpd3 Slbp HUR (ELAVL1) BINDS AND STABILIZES MRNA%REACTOME DATABASE ID RELEASE 59%450520 HuR (ELAVL1) binds and stabilizes mRNA Nup214 Prkcd Elavl1 Anp32a Tnfsf13 Xpo1 Prkca TRANSLESION SYNTHESIS BY POLK%REACTOME%R-HSA-5655862.1 Translesion synthesis by POLK Rev1 Pcna Polk Rfc5 Mad2l2 Rpa2 Rpa1 Ubc Rfc3 Rpa3 Rfc2 Rfc4 Rfc1 Rev3l TCF7L2 MUTANTS DON'T BIND CTBP%REACTOME%R-HSA-5339700.2 TCF7L2 mutants don't bind CTBP Ctbp1 Ctbp2 Tcf7l2 SYNTHESIS OF KETONE BODIES%REACTOME%R-HSA-77111.4 Synthesis of Ketone Bodies Hmgcs2 Bdh2 Bdh1 Acat1 Aacs Hmgcll1 Hmgcl GAP JUNCTION TRAFFICKING%REACTOME%R-HSA-190828.1 Gap junction trafficking Ap2m1 Myo6 Gjd2 Dnm2 Dnm1 Dab2 Clta Gjd3 Gjb1 Gjd4 Gjb2 Cltc Gja1 Gjb4 Gjb3 Gja10 Gjc1 Gja8 Gja3 Gja5 Gjb6 Gjb5 Gja4 Gjc2 Cltb KETONE BODY CATABOLISM%REACTOME%R-HSA-77108.3 Ketone body catabolism Bdh1 Acat1 Oxct1 ACTIVATION OF CAMK IV%REACTOME DATABASE ID RELEASE 59%442745 Activation of CaMK IV Camk4 DEFECTS IN VITAMIN AND COFACTOR METABOLISM%REACTOME DATABASE ID RELEASE 59%3296482 Defects in vitamin and cofactor metabolism Mccc2 Mccc1 Pcx Mmachc Gif Amn Mut Mtrr Cd320 Cubn Mmadhc Pcca Mmaa Acaca Tcn2 Pccb Mtr PI3K AKT SIGNALING IN CANCER%REACTOME%R-HSA-2219528.1 PI3K AKT Signaling in Cancer Egf Casp9 Fgf23 Fgf22 Fgf20 Tsc2 Frs2 Pdgfrb Pdgfra Mlst8 Vav1 Mapkap1 Fgf1 Egfr Bad Gab1 Fgf2 Rps6kb2 Mtor Erbb2 Fgf9 Pik3cb Fgf7 Foxo3 Pik3cd Fgf6 Foxo1 Fgf4 Fgf3 Fyn Creb1 Pik3ca Cdkn1b Nr4a1 Prr5 Hgf Cd86 Chuk Nrg2 Ereg Cdkn1a Nrg1 Akt2 Akt3 Pdgfb Cd80 Fgfr4 Nrg3 Nrg4 Akt1s1 Kit Akt1 Cd19 Fgf16 Fgf15 Gsk3a Klb Gsk3b Fgf18 Pik3ap1 Met Trat1 Rictor Irs2 Mdm2 Pdpk1 Lck Hbegf Irs1 Pik3r3 Btc Pik3r1 Ptpn11 Fgf10 Pik3r2 GLYCEROPHOSPHOLIPID BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 59%1483206 Glycerophospholipid biosynthesis Lclat1 Crls1 Pla2g6 Taz Hadhb Hadha Mfsd2a Dgat2 Chkb Pld3 Csnk2a2 Etnppl Cept1 Dgat2l6 Chat Dgat1 Chka Gnpat Pgs1 Pitpnm1 Abhd4 Pcyt2 Abhd3 Slc44a3 Mgll Lpcat1 Slc44a4 Slc44a5 Slc44a1 Slc44a2 Csnk2b Aldh7a1 Lpgat1 Bhmt Pld2 Pld1 Plb1 Gpd1l Pld4 Gpcpd1 Cpne3 Acp6 Pemt Pla2g5 Cpne1 Pla2g4d Gpd1 Pla2g4e Pla1a Cpne7 Pla2g4f Cpne6 Mboat2 Mboat7 Chdh Pla2g2e Pnpla2 Pla2g12a Cds2 Osbpl8 Agpat6 Pla2g2d Agpat5 Pla2g1b Etnk1 Pla2g2f Pnpla8 Osbpl5 Lpcat4 Lpcat3 Pla2g4a Pla2g10 Phospho1 Pnpla3 Pla2r1 Pla2g16 Mboat1 Awat2 Osbpl10 Alpi Gpam Cdipt Lpcat2 Lpin2 Plbd1 Ept1 Pitpnb Pitpnm2 Stard10 Pitpnm3 Hrasls5 Ptdss2 Ptdss1 Hrasls Ddhd1 Ache Lpin3 Pla2g3 Lpin1 Stard7 Dmgdh Pcyt1a Pcyt1b Sardh Pctp Cds1 Bche Tmem86b Pla2g4c Agpat3 Agpat4 Agpat1 Agpat2 Pisd Agpat9 Chpt1 Gpat2 FGFR1C AND KLOTHO LIGAND BINDING AND ACTIVATION%REACTOME%R-HSA-190374.2 FGFR1c and Klotho ligand binding and activation Fgf23 O-LINKED GLYCOSYLATION%REACTOME DATABASE ID RELEASE 59%5173105 O-linked glycosylation Wbscr17 St6galnac4 St6galnac3 Chst4 B3galnt2 Gcnt7 Pomt1 Kcna6 Pomgnt2 Pomt2 Pomgnt1 Adamts13 C1galt1c1 Sbspon Adamts14 Adamts15 Spon2 Thsd7a Galntl5 Spon1 Adamts3 Adamts6 B4galt5 Adamts7 B4galt6 Adamts2 Thbs1 Thsd7b Muc1 St6gal1 B3gntl1 Muc4 Thbs2 Adamts12 Thsd4 Gyltl1b Muc15 Adamts19 Muc20 Thsd1 Adamts10 Large Sspo Muc13 Pomk St3gal4 Adamts20 C1galt1 B4gat1 B3glct Pofut2 Cfp St6galnac2 Adamtsl3 Adamtsl4 Adamts4 Adamtsl1 Adamts1 Adamtsl2 Sema5a Dag1 Adamts8 Gcnt1 Adamts5 Gcnt3 Adamtsl5 A4gnt Galnt12 Galnt13 St3gal1 B3gnt3 Galnt10 St3gal2 B3gnt2 Galnt11 B3gnt7 Galnt16 Galnt1 B3gnt6 Adamts18 Galnt18 Galnt2 B3gnt5 Galnt14 B3gnt4 Adamts16 Galnt15 B3gnt9 Galnt7 B3gnt8 Galnt3 Galnt6 Galnt4 Galnt5 Sema5b TP53 REGULATES TRANSCRIPTION OF ADDITIONAL CELL CYCLE GENES WHOSE EXACT ROLE IN THE P53 PATHWAY REMAIN UNCERTAIN%REACTOME DATABASE ID RELEASE 59%6804115 TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain Cnot4 Cnot7 Cnot6l Cdc25c Cnot6 Trp53 Cnot1 Btg2 Cnot3 Plk3 Cnot11 Npm1 Cnot2 Cenpj Cnot8 Cnot10 Plk2 Rqcd1 Rgcc Tnks1bp1 NRCAM INTERACTIONS%REACTOME DATABASE ID RELEASE 59%447038 NrCAM interactions Dlg4 Cntn2 Dlg1 Nrp2 Ank1 Nrcam Dlg3 TFAP2 (AP-2) FAMILY REGULATES TRANSCRIPTION OF GROWTH FACTORS AND THEIR RECEPTORS%REACTOME%R-HSA-8866910.3 TFAP2 (AP-2) family regulates transcription of growth factors and their receptors Tfap2b Tfap2a Tgfa Egfr Esr1 Atad2 Tfap2c Vegfa Erbb2 Kit Yy1 Cga TRANSMISSION ACROSS ELECTRICAL SYNAPSES%REACTOME DATABASE ID RELEASE 59%112307 Transmission across Electrical Synapses Gja10 Gjc1 Panx1 Panx2 Gjd2 NIK-->NONCANONICAL NF-KB SIGNALING%REACTOME DATABASE ID RELEASE 59%5676590 NIK-->noncanonical NF-kB signaling Psmc6 Psmc5 Psmc2 Psmd2 Psmb9 Psmb8 Psmf1 Psme4 Btrc Nfkb2 Fbxw11 Skp1a Psmc1 Psmc4 Psmc3 Cul1 Psme3 Chuk Uba3 Psmd12 Psma7 Psmd11 Map3k14 Relb Psmd14 Psma5 Psmb5 Psmb4 Psmd13 Ubc Psmd10 Psma4 Psma3 Psmb7 Psma6 Psmb6 Psmb2 Psmb3 Ube2m Psma2 Psmb1 Psma1 Psmd9 Psmd1 Shfm1 Psme2 Psme1 Psmd3 Psmd4 Psmb10 Psmd6 Psmd5 Psmd7 Psmb11 Psmd8 MITOCHONDRIAL PROTEIN IMPORT%REACTOME%R-HSA-1268020.1 Mitochondrial protein import Vdac1 Slc25a12 Pmpca Pmpcb Coa4 Timm17b Chchd10 Timm8a1 Ldhd Samm50 Atp5b Slc25a13 Hspa9 Taz Tomm40 Dnajc19 Coa6 Atp5a1 Timm21 Timm22 Cmc2 Slc25a4 Cox19 Tomm6 Hspd1 Gfer Tomm7 Cyc1 Timm9 Tomm70a Slc25a5 Bcs1l Hscb Timm13 Coq2 Mtx1 Mtx2 Timm10 Tomm22 Timm10b Gm21987 Timm50 Cox17 Chchd5 Chchd7 Timm8b Chchd2 Chchd3 Chchd4 Fxn Idh3g Timm44 Grpel1 Grpel2 Aco2 Cs CYTOCHROME C-MEDIATED APOPTOTIC RESPONSE%REACTOME%R-HSA-111461.2 Cytochrome c-mediated apoptotic response Casp3 Casp9 Casp7 Apaf1 METABOLISM OF STEROID HORMONES%REACTOME DATABASE ID RELEASE 59%196071 Metabolism of steroid hormones Cyp21a1 Hsd17b14 Hsd17b3 Hsd17b1 Cga Lhb Akr1b3 Cyp19a1 Hsd17b11 Hsd17b2 Hsd17b12 Akr1b8 Srd5a2 Pomc Hsd3b1 Hsd3b6 Srd5a1 Cyp11b1 Srd5a3 Cyp11b2 Fdx1 Cyp17a1 Fdx1l Star Stard4 Cyp11a1 Stard3nl Stard3 Fdxr Hsd11b1 Hsd11b2 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY%REACTOME%R-HSA-110373.1 Resolution of AP sites via the multiple-nucleotide patch replacement pathway Pole Parg Apex1 Parp2 Pold1 Pold2 Pcna Pold3 Pold4 Polb Rfc5 Pole2 Rpa2 Parp1 Rfc3 Rpa1 Rpa3 Rfc2 Lig1 Rfc4 Fen1 Pole4 Rfc1 Pole3 HOST INTERACTIONS OF HIV FACTORS%REACTOME DATABASE ID RELEASE 59%162909 Host Interactions of HIV factors Nup85 Nup160 Cdk9 Hmga1 Xpo1 Btrc Elmo1 Rac1 Npm1 Slc25a4 Ccnt1 Psip1 Banf1 Nup107 Ap2m1 Rbx1 Rcc1 Nup37 Psmd12 Nup43 Nup133 Psmd11 Ap2a1 Psmd14 Ap2a2 Psmd13 Psmd10 Ranbp1 Ap2s1 Shfm1 Pak2 Ap2b1 Dock2 Atp6v1h Lck Ranbp2 Cd4 Psmc6 Psmc5 Psmc2 Psmd2 Nup50 Tpr Psmb9 Psmf1 Psmb8 Psme4 Ndc1 Nup214 Aaas Nup210 Nup188 Skp1a Nup54 Nup35 Psmc1 Nupl2 Arf1 Psmc4 Nup62 Nup205 Psmc3 Nup155 Psme3 Nup88 Pom121 Rae1 Hck Fyn Nup93 Nup153 Ran Slc25a5 Cd8b1 Psma7 Cul5 Psma5 Psmb5 Psmb4 Ubc Psma4 Psma3 Psmb7 Psma6 Psmb6 Psmb2 Psmb3 Psma2 Psmb1 Psma1 Ppia Psmd9 Tceb1 Kpnb1 Psmd1 Psme2 Psme1 Kpna1 Ap1s2 Psmd3 Ap1b1 Psmd4 Ap1s1 Ap1g1 Psmb10 Pacs1 Psmd6 H2-Q10 Psmd5 Ap1s3 Psmd7 Psmb11 B2m Psmd8 Ap1m2 Ap1m1 VASOPRESSIN REGULATES RENAL WATER HOMEOSTASIS VIA AQUAPORINS%REACTOME DATABASE ID RELEASE 59%432040 Vasopressin regulates renal water homeostasis via Aquaporins Gngt1 Adcy7 Gng7 Adcy6 Adcy5 Gng4 Adcy4 Adcy3 Adcy2 Gngt2 Prkar2a Adcy1 Gng10 Prkacb Adcy9 Adcy8 Aqp2 Aqp3 Prkar2b Rab11fip2 Rab11a Aqp1 Myo5b Gng11 Gng13 Gng12 Gnb2 Gnb1 Aqp4 Gnb3 Avp Prkar1a Gnb5 Prkar1b Avpr2 Gnb4 Prkaca Gng8 Gng3 Gng2 RAB GERANYLGERANYLATION%REACTOME DATABASE ID RELEASE 59%8873719 RAB geranylgeranylation Rab33a Rab36 Rab40c Rab5c Rab40b Rab5b Rab30 Rab33b Rab39 Rab8a Rab2a Rab22a Rab3c Rab14 Rab38 Rab11a Rab3d Rab1 Rab3b Rab32 Rabggta Rab31 Rab4b Rabggtb Rab19 Rab17 Rab37 Rab12 Rab27a Rab13 Rab34 Rab10 Rab35 Rab20 Rab21 Rab29 Rab42 Rab23 Rab24 Rab2b Rab25 Rab26 Rab5a Rab27b Rab9 Ptp4a2 Chm Rab11b Rab43 Rab39b Chml Rab4a Rab8b Rab7 Rab1b Rab9b Rab18 Rab3a Rab6b Rab6a CARBOHYDRATE METABOLISM%REACTOME%R-HSA-71387.5 Carbohydrate metabolism Agrn Chit1 Hyal2 Nup85 Nup160 Lum Ppp2r1a Ndst2 G6pdx Naglu B4galt7 Dse Hyal1 Hyal3 Dcxr Slc50a1 Arsb G6pc Nup107 Hs3st2 Nup37 B3gat3 Nup43 B3gat2 Nup133 B3gat1 Hs3st5 Hs3st6 Hs3st4 Hs3st1 Cryl1 Chst2 Chst5 Hs2st1 Chst1 Glce Xylt2 Xylt1 Dsel Slc25a1 Aldoc Aldob Ext2 Aldoa Ext1 Chp1 Pfkfb4 Ust Gbe1 Pcx Glb1 Gys2 Eno2 Ndst3 Eno3 Ugp2 Ndst1 Ndst4 Tpi1 Ids Pgk2 Chia1 Galt Eno1 Pgk1 Pfkm Idua B3gnt3 Pfkp Hs3st3a1 B3gnt2 Pfkl Fbp1 B3gnt7 Xylb Nhlrc1 Ranbp2 Phkg1 Fbp2 B3gnt4 Akr1a1 Bpgm Pfkfb3 Glyctk Khk Pfkfb2 Hs3st3b1 Tkfc Pgam1 Pgam2 Got2 Pgm2 Pfkfb1 Gck Nup50 Tpr Ndc1 Slc2a5 Nup214 Hexb Aaas Nup210 Nup188 Nup54 Nup35 Nupl2 Nup62 Slc2a4 Slc2a3 Nup205 Nup155 Slc2a2 Nup88 Pom121 Slc2a1 Slc37a4 Rae1 Rpia Pgm1 Pgls Tkt Nup93 Pgd Rpe Dera Taldo1 Nup153 Pck1 Omd Prelp Kera Ogn Hmmr Ppp2cb Hexa Ppp2ca Ubc Got1 Slc45a3 Stab2 Slc5a10 Fgf21 Mdh2 Gpi1 Gns G6pc2 G6pc3 Chst3 Chsy1 Chpf Bgn Dcn Chsy3 Lyve1 Bcan Chst15 Gale Galk1 Hpse2 Cspg4 Cspg5 Hs6st1 St3gal4 Hs6st3 Hs6st2 Chst13 Csgalnact1 Csgalnact2 Sgsh Ncan Chst12 Vcan Chst7 Chst11 Ppp2r1b Lalba Chst14 B3galt6 Gys1 Gyg Hk1 Gapdhs Agl Ppp1r3c Phka1 Eno1b Slc25a10 Slc25a12 Prkacb Hk2 Pygm Hk3 Sord Pck2 Pygl Akr1b3 Gnpda2 Adpgk Gusb Ppp2r5d Gnpda1 Hpse Phkg2 Slc25a13 Amy1 Slc25a11 Gaa Mgam Phka2 Lct Epm2a Sis Mdh1 Amy2a3 Phkb Treh Pygb B4galt3 Slc35b2 B4galt1 Slc26a1 B4galt5 B4galt4 B4galt6 B4galt2 Prkaca Slc26a2 Slc35b3 Papss2 Aldh1a1 Papss1 Slc5a2 Slc5a3 Slc5a1 Slc5a9 Slc5a4a B4gat1 Slc9a1 Sdc3 Man2c1 Sdc4 Man2b2 Manba Gpc6 Sdc2 Man2b1 Gpc3 Sdc1 Gpc5 Gpc2 Gckr Gpc4 Fmod Prps1l1 St3gal1 Prps2 St3gal2 Has3 Abcc5 Has1 Slc35d2 Cemip Has2 Cd44 Hspg2 Prps1 St3gal6 Gpc1 MRNA CAPPING%REACTOME%R-HSA-72086.2 mRNA Capping Gtf2h5 Gtf2h4 Gtf2h3 Ercc3 Rngtt Rnmt Ercc2 Polr2i Polr2f Polr2j Polr2e Polr2h Polr2c Mnat1 Polr2d Polr2b Polr2k Polr2g Ccnh Polr2a Cdk7 Supt5 Gtf2h1 Gtf2f1 Ncbp1 Ncbp2 Gtf2h2 Gtf2f2 CHAPERONIN-MEDIATED PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 59%390466 Chaperonin-mediated protein folding Cct5 Gngt1 Gapdhs Gng7 Tcp1 Tubb6 Cct8 Gng4 Cct4 Cct7 Tubb3 Gngt2 Tubb1 Actb Gng10 Gnaz Tubb2b Tubal3 Tubb2a Tuba8 Pfdn2 Rgs11 Fbxw10 Pfdn6 Tuba3b Sphk1 Pfdn1 Ccne1 Pfdn4 Fbxo4 Pfdn5 Skiv2l Fbxo6 Ccne2 Fbxw2 Dcaf7 Fbxw5 Fbxw4 Fbxw9 Fbxw7 Gnai2 Tubb4a Gnai1 Tubb4b Usp11 Gnai3 Tuba4a Gng11 Nop56 Gng13 Gng12 Gnb2 Arfgef2 Gnb1 Gnb3 Kif13a Gnb5 Gnb4 Gba Gng8 Gng3 Gng2 Wrap53 Xrn2 Csnk2a2 Vbp1 Tuba1a Fkbp9 Tuba1b Stat3 Tuba1c Cct2 Cct6b Cct3 Rgs7 Rgs6 Rgs9 Trp53 Ap3m1 Gnat1 Gnat2 Pdcl Gnat3 Gnao1 Csnk2b Fbxl5 Fbxl3 Lonp2 Hdac3 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR%REACTOME%R-HSA-1234158.2 Regulation of gene expression by Hypoxia-inducible Factor Crebbp Cited2 Arnt Car9 Vegfa Ep300 Epas1 Epo Hif3a Hif1a BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS%REACTOME DATABASE ID RELEASE 59%111453 BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members Bad Bcl2 Bcl2l1 Bmf Bid Bcl2l11 3' -UTR-MEDIATED TRANSLATIONAL REGULATION%REACTOME DATABASE ID RELEASE 59%157279 3' -UTR-mediated translational regulation Rpl39 Rplp1 Eif2s1 Eif2s2 Eif3i Eif3k Eif3l Eif3m Rpl7 Rps21 Rplp2 Rps27 Eif3a Eif3b Eif3c Rps25 Rpl4 Eif3d Rps26 Rps27l Eif3e Rpl18a Rpl34 Rpl32 Eif3f Eif3h Eif3g Rpl26 Rpl24 Rps9 Eif2s3x Rps7 Rps5 Rpsa Rpl37 Rps4x Eif4b Eif4a1 Eif4a2 Rpl22 Eif1ax Rpl10l Rpl23 Rpl39l Eif3j2 Rpl13a Rpl22l1 Rps15a Rpl11 Rpl17 Rps3 Rpl19 Rpl18 Rps16 Eif4e Rps14 Rps19 Rps18 Eif4h Pabpc1 Rps11 Eif4g1 Rps10 FGFR2 ALTERNATIVE SPLICING%REACTOME%R-HSA-6803529.2 FGFR2 alternative splicing Hnrnph1 Polr2f Polr2i Polr2e Polr2j Polr2h Polr2c Polr2d Rbfox2 Polr2b Esrp2 Tia1 Ptbp1 Polr2g Polr2k Tial1 Polr2a Hnrnpm Hnrnpa1 Hnrnpf Gtf2f1 Ncbp1 Ncbp2 Gtf2f2 HYALURONAN METABOLISM%REACTOME%R-HSA-2142845.1 Hyaluronan metabolism Hexa Hyal2 Chp1 Lyve1 Hexb Has3 Abcc5 Gusb Has1 Cemip Hmmr Has2 Slc9a1 Cd44 Hyal1 Stab2 Hyal3 DISPLACEMENT OF DNA GLYCOSYLASE BY APEX1%REACTOME%R-HSA-110357.1 Displacement of DNA glycosylase by APEX1 Nthl1 Ogg1 Apex1 Mpg Mbd4 Smug1 Mutyh SIGNALING BY LIGAND-RESPONSIVE EGFR VARIANTS IN CANCER%REACTOME%R-HSA-5637815.1 Signaling by Ligand-Responsive EGFR Variants in Cancer Shc1 Egf Kras Nras Cdc37 Hsp90aa1 Plcg1 Pik3ca Hras Sos1 Ubc Egfr Gab1 Cbl Pik3r1 TGFBR1 KD MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 59%3656532 TGFBR1 KD Mutants in Cancer Tgfbr1 Tgfb1 Fkbp1a Tgfbr2 Smad2 Smad3 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION%REACTOME DATABASE ID RELEASE 59%749476 RNA Polymerase III Abortive And Retractive Initiation Brf2 Nfia Nfic Ssb Pou2f1 Nfix Zfp143 Polr2f Polr2e Polr2h Tbp Gtf3c1 Gtf3c6 Gtf3c3 Gtf3c2 Bdp1 Gtf3c4 Polr2k Crcp Polr3a Polr3gl Snapc2 Polr3k Snapc1 Snapc4 Polr3h Brf1 Polr3f Polr3g Snapc5 Gtf3c5 Polr1d Polr1c Polr3d Polr3e Snapc3 Polr3b Gtf3a Polr3c NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 59%187037 NGF signalling via TRKA from the plasma membrane Akap9 Ppp2r1a Mapkapk3 Map2k5 Csf2 Cd86 Jak1 Ap2m1 Cd80 Ap2a1 Stat3 Ap2a2 Sh3gl2 Dnm2 Rps6ka5 Ap2s1 Dnm1 Rps6ka3 Rps6ka2 Rps6ka1 Clta Ap2b1 Cltc Dnm3 Adcy7 Adcy6 Adcy5 Adcy4 Adcy3 Adcy2 Prkar2a Adcy1 Frs2 Nras Frs3 Rasgrf1 Adcy9 Psmf1 Adcy8 Raf1 Psme4 Il5ra Fgf1 Bad Il17rd Fgf2 Cnksr1 Csk Cnksr2 Erbb2 Fgf9 Ptk2 Fgf7 Psme3 Vrk3 Fgf6 Elk1 Mef2c Fgf4 Mef2a Fgf3 Dusp3 Mapk7 Adora2a Ppp5c Prkar1a Prkar1b Ranbp9 Ppp2cb Shc1 Lamtor2 Chuk Nrg2 Ppp2ca Shc3 Nrg1 Akt2 Akt3 Shc2 Psma7 Artn Nrtn Plcg1 Brap Psmb5 Psmb4 Ubc Nrg3 Psmb7 Nrg4 Psmb6 Psmb2 Psmb3 Psmb1 Mapk3 Akt1 Mapk1 Ksr1 Ptpra Dusp16 Dusp10 Map3k11 Pip4k2b Pip4k2a Trp53 Pip4k2c Paqr3 Pik3ap1 Pde1c Pde1b Psme2 Pde1a Psme1 Ncam1 Sos1 Rictor Braf Psmb10 Apbb1ip Ahcyl1 Rapgef1 Psmb11 Csf2rb2 Rapgef2 Csf2ra Mov10 Casp9 Prkcd Prkce Actn2 Nf1 Prkcg Tsc2 Pdgfrb Pdgfra Mlst8 Kbtbd7 Prkca Vav1 Il2rg Arrb2 Egfr Gab1 Arrb1 Mtor Ret Phlpp1 Rhoa Ntrk1 Adrbk1 Ntrk2 Vwf Ralb Phlpp2 Rala Mapkapk2 Ins2 Sptan1 Pspn Map2k1 Rbx1 Crkl Fgg Cdkn1a Map2k2 Cul3 Psmd12 Pdgfb Psmd11 Rasgef1a Psmd14 Rasa3 Rasa4 Psmd13 Psmd10 Il2 Rasa2 Rasa1 Nefl Spred3 Kit Spred2 Grin2a Spta1 Spred1 Il5 Sptbn4 Ppp2r1b Ywhab Ago2 Ago1 Tnrc6c Kras Insr Gsk3a Gsk3b Tnrc6b Gdnf Shfm1 Tnrc6a Ago4 Ago3 Itpr1 Trat1 Irs2 Mdm2 Lck Syngap1 Pten Hbegf Irs1 Il3ra Btc Il2ra Il2rb Itpr3 Ptpn11 Angpt1 Itpr2 Trib3 Psmc6 Egf Fgf23 Adcyap1r1 Psmc5 Adcyap1 Fgf22 Mark3 Psmc2 Fgf20 Psmd2 Dab2ip Prkacb Tek Psmb9 Psmb8 Araf Hras Grin1 Prkar2b Ppp2r5e Mapkap1 Dlg4 Ppp2r5c Rps6kb2 Ppp2r5d Ppp2r5a Psmc1 Psmc4 Psmc3 Pik3cb Foxo3 Sptbn2 Pik3cd Foxo1 Sptbn1 Itgb3 Fyn Creb1 Phb Grin2c Rasgrp4 Rasgrp3 Pebp1 Camk4 Ppp2r5b Rasgrp1 Ier3 Tln1 Pik3ca Cdkn1b Fga Fgb Grin2d Prkaca Grin2b Nr4a1 Sptb Prr5 Hgf Gfra2 Gfra3 Pip5k1a Gfra4 Ereg Jak2 Pea15a Itga2b Rap1a Jak3 Wdr83 Camk2d Rap1b Camk2a Fgfr4 Camk2b Psma5 Rasal3 Rasal2 Psma4 Psma3 Psma6 Akt1s1 Vcl Camk2g Psma2 Psma1 Gfra1 Pip5k1b Cd19 Pip5k1c Rit2 Psmd9 Ngf Dusp7 Iqgap1 Rit1 Fgf16 Ralgds Dusp6 Dusp9 Fgf15 Dusp8 Klb Fgf18 Them4 Psmd1 Met Fn1 Kidins220 Mapk11 Rasal1 Dusp1 Mapk13 Psmd3 Mapk12 Psmd4 Mapk14 Pdpk1 Psmd6 Psmd5 Dusp2 Pik3r3 Psmd7 Crk Pik3r1 Dnal4 Dusp5 Psmd8 Fgf10 Pik3r2 Dusp4 DEVELOPMENTAL BIOLOGY%REACTOME%R-HSA-1266738.3 Developmental Biology Agrn Cacng8 Cacng4 Cacng3 Srebf2 Cacng2 Thrap3 Dok2 Scn1a Scn1b Shtn1 Nrcam Ncoa3 Rdx Gap43 Hes1 Scn2a1 Scn5a Lamc1 Ap2m1 Med1 Nrp1 Csnk2a2 Scn9a Hspa8 Dlg1 Kcnq3 Nrp2 Sdcbp Cntnap1 Cntn6 Ap2a1 Dlg3 Kcnq2 Ap2a2 Msn Scn2b Cntn1 Cntn2 Lamb1 Sh3gl2 Itgav Med4 Dnm2 Scn10a Lypla2 Med8 Ephb2 Med6 Tmem147 Rps6ka5 Ncln Ap2s1 Dnm1 Nomo1 Chl1 Rps6ka6 Rps6ka4 Rps6ka3 Rps6ka2 Rps6ka1 Scn3a Scn3b Med9 Slit1 Lama1 Slit3 Scn11a L1cam Hfe2 Vav2 Rgma Clta Rgmb Ap2b1 Agap2 Csnk2b Ablim3 Ezr Ablim2 Alcam Kif4 Ablim1 Cltc Numb Scn7a Dnm3 Dpysl2 Itga1 Itga2 Scn8a Scn4b Dok5 Itga9 Dok6 Scn4a Itga10 Dok4 Itga5 Dcx Cdk19 Fam120b Nfasc Capn1 Csk Capns1 Slc2a4 Slc2a2 Spag9 Tbc1d24 Mef2d Bnip2 Tcf12 Myf6 Cdon Myod1 Med13l Med22 Adam10 Med28 Med29 Med21 Med11 Med19 Gab2 Cacna1s Ppargc1a Ntn4 Med18 Cacnb4 Cacnb1 Helz2 Hnf4g Polr2i Polr2j Polr2c Polr2d Map2k6 Polr2b Polr2g Nr5a1 Polr2a Med20 Med27 Med26 Ctnnb1 Mef2b Tcf4 Neo1 Myog Tcf3 Med23 Ctnna2 Med24 Myf5 Med25 Ncan Havcr2 Kdr Rxra Unc5b Carm1 Unc5a Ptpn11 Tbl1xr1 Rara Rarb Ccnc Hsp90aa1 Yy1 Plin1 Clasp1 Fabp4 Crebbp Prkaca Rbpj Cap1 Rarg Lefty2 Tgfb1 Ncoa1 Ncoa6 Ncoa2 Perp Cdk8 Ctnna1 Rac1 Jun Smad4 Pak1 Smad2 Smad3 Wasl Rqcd1 Ep300 Dcc Med31 Adipoq Tbl1x Med30 Rbbp7 Dsg1a Dsg3 Dsp Dsg2 Pkp1 Pcgf2 Cd36 Unc5c Unc5d Cnot6 Frs2 Nras Frs3 Rasgrf1 Med13 Psmf1 Med14 Med12 Raf1 Psme4 Il5ra Med10 Fgf1 Il17rd Chd9 Fgf2 Cnksr1 Med16 Cnksr2 Med17 Erbb2 Fgf9 Med15 Ptk2 Fgf7 Psme3 Cdk4 Fgf6 Fgf4 Fgf3 Ncor1 Shank3 Ncor2 Furin Ppp5c Ranbp9 Smarcd3 Ppp2cb Shc1 Lamtor2 Nrg2 Ppp2ca Ppara Shc3 Nrg1 Pparg Akt2 Akt3 Shc2 Psma7 Artn Nrtn Plcg1 Brap Nck2 Psmb5 Psmb4 Ubc Nrg3 Psmb7 Nrg4 Psmb6 Psmb2 Psmb3 Psmb1 Nck1 Mapk3 Akt1 Mapk1 Ksr1 Ptpra Dusp16 Dusp10 Map3k11 Cacnb2 Cacnb3 Paqr3 Cacna1c Cacna1d Psme2 Psme1 Ncam1 Sos1 Braf Psmb10 Apbb1ip Col6a1 Col6a2 Col6a3 Col6a6 Psmb11 Csf2rb2 Rapgef2 Angptl4 Csf2ra Egr2 Hoxa4 Dock1 Hoxa1 Hoxa3 Ctcf Hoxd1 Hoxd4 Hoxd3 Pias2 Kdm6a Hoxc4 Zfp335 Hoxb4 Hoxb3 Hoxb2 Hoxb1 Rhoa Mafb Hoxa2 Arhgap35 Pknox1 Meis1 Hnf1a Rfx6 Nkx6-1 Neurod1 Foxa2 Mafa Foxa3 Pdx1 Nkx2-2 Yes1 Ebf1 Nr2f2 Lyn Zfp638 Zfp467 Klf5 Cebpa Itgb1 Polr2f Polr2e Polr2h Polr2k Jup Cdh2 Cdh4 Tyrobp Ntn1 Vasp Mapk11 Mapk12 Mapk14 Cdh15 Actb Acvr1b Nodal Drap1 Pfn2 Dand5 Pfn1 Foxh1 Acvr2b Acvr2a Arpc5 Acvr1c Lefty1 Arpc4 Cer1 H2afj H2afb2 Sos2 Hist2h2be Trio Hist2h2ac H3f3b H3f3a Hist1h2bg Hist1h2bh Srgap2 Arhgap39 Actg1 Hist1h2bp Hist1h2bm Hist1h2bj Srgap3 Hist1h2bb Srgap1 Neurog3 Pax4 Insm1 Arhgef7 Arpc1a Arpc1b Hist1h3d Hist1h2ak Hist1h2ag Itsn1 Hist1h2ah Gck Krt84 Krt86 Krt80 Krt82 Pkp3 Pkp2 2010005H15Rik Krt83 Tchh Krt39 Pkp4 Sprr2k Dsc2 2310034C09Rik Krtap3-2 Krtap3-1 Krt35 Krt34 Hist2h3c1 Dsc3 Gm11596 Notch1 Kazn Cdsn Krt32 Krt31 Krt27 4930553J12Rik Krt25 Krt26 Klk12 Krt33a Mef2c Krtap9-5 Mef2a Krt24 Krt23 Mapk7 Krt33b Casp14 Klk14 Krt20 Pck1 Ajuba Rhog Rhob Rock1 Rhoc Rock2 Eed Stx1a Grb7 Suz12 Actn2 Nf1 Pdgfrb Siah1a Pdgfra Efna2 Efna1 Kbtbd7 Prkca Efna3 Lgi2 Lgi1 Il2rg Arrb2 Adam22 Egfr Adam11 Gab1 Arrb1 Ret Siah2 Vwf Stx1b Adam23 Lgi4 Aph1b Lgi3 Iapp Sall1 Efna4 Pou5f1 Efnb3 Klf4 Arhgef28 Sall4 Efnb1 Prdm14 Foxd3 Zic3 Epas1 Efna5 Lin28a Sox2 Hif3a Epha1 Zscan10 Pbx1 Mmp2 Mmp9 Epha3 Epha2 Epha6 Epha7 Git1 Epha8 Ephb1 Ephb4 Epha4 Epha5 Ephb6 Efnb2 Ephb3 Cltb Pspn Krt72 Col4a5 Krt79 Gm11937 Map2k1 Krt73 Rbx1 Krtap15 Fgg Krt77 Krt78 Krtap24-1 Map2k2 Lce3b Cul3 Lor Psmd12 Pdgfb Krt76 Gm11563 Psmd11 Ezh2 Krtap1-4 Col9a1 Krtap4-16 Rasgef1a Krtap1-3 Col9a2 Krt40 Col9a3 Tgm5 Psmd14 Rasa3 Krtap19-4 Krtap17-1 Rasa4 Tgm1 Psmd13 Psmd10 Il2 Rasa2 Lce1m Rasa1 Krtap13-1 Nefl Spred3 Kit Spred2 Grin2a Spred1 Il5 Krtap16-3 Ppp2r1b Ywhab Krt10 Krt12 Krt13 Rptn Krtap26-1 Sprr1b Kras Krt18 Krt15 Gsk3b Krt14 Krt17 Krt16 Gdnf Krtap12-1 Shfm1 Cela2a Krt9 Krtap4-7 Krt7 Krt5 Krt2 Irs2 Krt8 St14 Syngap1 Krt4 Hbegf Klk8 Irs1 Evpl Il3ra Klk5 Btc Dsg4 Spink5 Il2ra Krt6a Il2rb Krtap4-2 Prss8 Angpt1 Krt75 Krt71 Psmc6 Egf Fgf23 Psmc5 Fgf22 Mark3 Psmc2 Fgf20 Psmd2 Dab2ip Prkacb Tek Psmb9 Slit2 Psmb8 Abl2 Araf Hras Cap2 Grb10 Grin1 Ppp2r5e Shb Dlg4 Ppp2r5c Ppp2r5d Ppp2r5a Psmc1 Psmc4 Psmc3 Pik3cb Foxo3 Pik3cd Foxo1 Itgb3 Cacna1i Fyn Cacna1h Creb1 Phb Trpc1 Grin2c Cacna1g Rasgrp4 Myo10 Prnp Rasgrp3 Pebp1 Ppp2r5b Ngef Rasgrp1 Tln1 Pik3ca Col4a3 Pak7 Col4a2 Robo2 Pak4 Col4a4 Robo1 Col4a1 Hist3h2ba Fga Pak6 Fgb Lep Grin2d Abl1 Grin2b Vav3 Hgf Pax6 Gfra2 Gfra3 Gfra4 Ereg Jak2 Cebpb Trpc4 Pea15a Itga2b Rap1a Jak3 Wdr83 Klk13 Camk2d Trpc5 Rap1b Camk2a Fgfr4 Camk2b Psma5 Rasal3 Rasal2 Psma4 Psma3 Psma6 H2afz Vcl Camk2g Psma2 H2afx Psma1 Gfra1 Evl Pip5k1c Psmd9 Tiam1 Dusp7 Iqgap1 Actr2 Fgf16 Actr3 Dusp6 Dusp9 Hist2h2aa1 Fgf15 Pcsk6 Dusp8 Psen2 Klb Kalrn Fgf18 Ncstn Psmd1 Met Fn1 Rasal1 Dusp1 Psmd3 Psmd4 Psmd6 Psmd5 St8sia4 Dusp2 Pik3r3 Arpc3 Psmd7 Pik3r1 Arpc2 Dusp5 Psmd8 Fgf10 Pik3r2 Hdac3 Dusp4 Trpc6 Akap9 Rap1gap Ppp2r1a Clasp2 Krt1 Nfkb1 Dok1 Wnt10b Rela Csf2 Trpc3 Wnt1 Ppl Trpc7 Tnf Jak1 Stat3 Paxip1 Rbbp4 Ins2 Ccnd3 Sptan1 St8sia2 Lpl Sema6a Sema6d Myl6 Myh11 Prkcq Dpysl5 Dpysl3 Farp2 Cd72 Myh14 Cdk5r1 Spta1 Myh10 Dpysl4 Ptprc Sptbn4 Limk1 Arhgef11 Limk2 Arhgef12 Plxnd1 Plxnc1 Sema5a Trem2 Plxnb3 Rras Plxnb1 Pak3 Pak2 Crmp1 Rnd1 Myl12b Plxna2 Myl12a Sema3e Sema4a Rac2 Wdr5 Sema4d Hsp90ab1 Sema7a Fes Plxna4 Plxna3 Myh9 Cdk5 Plxna1 Sema3a Kmt2c Ank1 Ank3 Kmt2d Sptbn2 Sptbn1 Sptb Pitpna Dsc1 Sdc2 Hnf1b Ash2l Onecut3 Onecut1 Rbbp5 Ptf1a Gpc1 METABOLISM OF SEROTONIN%REACTOME%R-HSA-380612.3 Metabolism of serotonin Aldh2 Maoa BASE EXCISION REPAIR%REACTOME%R-HSA-73884.1 Base Excision Repair Parg Apex1 Lig3 Pcna Rfc5 Parp1 Rfc3 Rfc2 Rfc4 Rfc1 Nthl1 Ogg1 Neil1 Pole Pold1 Parp2 Pold2 Mpg Xrcc1 Pold3 Pold4 Mbd4 Neil2 Smug1 Polb Pole2 Rpa2 Rpa1 Rpa3 Pnkp Lig1 Fen1 Pole4 Mutyh Pole3 RNA POLYMERASE II TRANSCRIPTION%REACTOME DATABASE ID RELEASE 59%73857 RNA Polymerase II Transcription Gtf2a1 Gtf2a2 Cdk9 Gtf2b Taf1 Taf2 Taf4b Taf7 Taf4a Rngtt Taf5 Rnmt Supt6 Taf6 Taf3 Polr2i Polr2j Gtf2e1 Nelfa Nelfb Gtf2e2 Polr2c Rtf1 Mnat1 Polr2d Supt4a Polr2b Zfp473 Aff4 Taf9 Polr2g Ccnt1 Ctdp1 Polr2a Wdr61 Nelfe Supt5 Nelfcd Gtf2f1 Ccnt2 Ncbp1 Ncbp2 Gtf2f2 Taf13 Paf1 Taf11 Eaf1 Ercc3 Lsm11 Ctr9 Lsm10 Taf12 Snrpb Snrpd3 Cdc73 Ercc2 Slbp Iws1 Leo1 Polr2f Polr2e Pabpn1 Polr2h Tbp Ell Srsf2 Thoc7 Thoc6 Srsf3 Taf9b Mllt1 Mllt3 Polr2k Slu7 Srsf11 Zc3h11a Ssrp1 Magoh Cpsf1 Cstf1 Dhx38 Clp1 Thoc3 Srsf7 Thoc2 Thoc5 Thoc1 Gtf2h1 Srsf9 Alyref Gtf2h2 Srsf6 Nudt21 Cstf2t Gtf2h5 Fip1l1 Rbm8a Gtf2h4 Cstf3 Casc3 Sympk Eif4a3 U2af1l4 Chtop Srsf1 Cstf2 Cpsf3 Cpsf2 Cpsf4 Gtf2h3 Cpsf7 Ddx39b Upf3b Ddx39 Papola Fyttd1 Wdr33 Rnps1 Poldip3 Magohb Cdc40 Srrm1 Tcea1 Ak6 Tceb1 Tceb3 Supt16 Ccnh Ccnk Cdk7 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA%REACTOME%R-HSA-3359485.1 Defective CD320 causes methylmalonic aciduria Cd320 Tcn2 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS%REACTOME%R-HSA-2029485.1 Role of phospholipids in phagocytosis Prkcd Fcgr4 Prkce Ppapdc1a Pld3 Ppapdc1b Plcg2 Fcgr3 Syk Fcgr1 Plcg1 Pik3ca Itpr1 Ahcyl1 Pld2 Pld1 Pik3r1 Pla2g6 Pik3cb Itpr3 Pld4 Cd3g Itpr2 Pik3r2 SYNTHESIS OF 12-EICOSATETRAENOIC ACID DERIVATIVES%REACTOME%R-HSA-2142712.1 Synthesis of 12-eicosatetraenoic acid derivatives Alox12b Alox12 Gpx2 Gpx1 Alox15 Gpx4 CLASS II GLUTS%REACTOME%R-HSA-428776.1 Class II GLUTs Slc2a5 Slc2a9 Slc2a7 ASPARAGINE N-LINKED GLYCOSYLATION%REACTOME%R-HSA-446203.4 Asparagine N-linked glycosylation Vcp St6gal2 Rft1 Uap1 Ubxn1 Nagk Magt1 Fuk B4galnt2 Gmppa Gmppb Cmas Dad1 Engase Tsta3 Asgr1 Calr Fuom Asgr2 Pdia3 Tusc3 Mpi Ctsa Glb1 Gfpt2 Gnpnat1 Alg10b Mvd Nudt14 Alg5 Ddost Dpm1 Dpm2 Dpm3 Mogs Ubc Chst8 Os9 Rnf185 Derl2 Rnf5 Dpagt1 Rnf139 Man1b1 Uggt2 Edem3 Amfr Trim13 Uggt1 Edem2 Edem1 Rnf103 Syvn1 Sel1l March6 Ngly1 Neu1 Neu3 Neu2 Neu4 Trappc2 Tgfa Trappc3 Ins2 Mgat5 Mcfd2 Trappc1 Rab1 Nus1 F5 Preb Slc17a5 Copa F8 Sec24a Sec24b Sptan1 Sec13 Chst10 Tmed3 Mpdu1 Mgat4a Mgat4b Sec24d Scfd1 Gria1 Sec24c Man2a1 Fut8 Arcn1 Tfg St6gal1 Ykt6 Cd59b Mgat4c Cog6 Lman2l Rpn2 Cog3 Cog4 Dhdds Cog2 St8sia3 Sec31a Cog1 Gmds Ctage5 Gorasp1 Nsf St8sia2 Trappc6a St8sia6 Trappc6b Tmed9 Man1c1 Bet1l Gbf1 Ankrd28 St3gal4 Renbp Man1a Trappc9 Pgm3 Mgat3 Napb Napg Mgat2 Mgat1 Napa Trappc5 Rpn1 Spta1 Trappc4 Sptbn4 Fpgt Dctn5 Dctn6 Stt3a Ctsz Dctn1 Serpina1d Col7a1 Lman1l Dctn4 Areg Serpina1a Dync1li2 Folr1 Dync1li1 Man1a2 Rab1b Ppp6r1 Ppp6r3 Arf5 Cnih1 Kdelr2 Pmm2 Kdelr3 Pmm1 Uso1 Bet1 Stx17 Cnih3 Ctsc Cnih2 Cog7 Tmem115 Cog8 Fuca1 Arfgap3 St6galnac6 Arfgap1 St6galnac5 Arfgap2 St6galnac4 Sar1b St6galnac3 Golgb1 Copb2 Umod Stx5a Canx Manea Ganab Copb1 Ppp6c Copz1 Ank1 Ank3 Sec23a Copz2 Cga Lhb Trappc10 Sec23ip Copg1 Gosr1 Golga2 Alg11 Dynll2 Alg14 Gosr2 Arf1 Psmc1 Kdelr1 Arf3 Arf4 Dync1i1 Sptbn2 Trappc2l Sptbn1 Csnk1d Mlec Gne Dynll1 Npl Amdhd2 B4galt3 Tbc1d20 Nans B4galt1 Cope Nanp B4galt5 B4galt4 B4galt6 Rad23b B4galt2 Sec16b Alg3 Sec22a Alg6 Dync1i2 Lman1 Alg8 Sec22b Prkcsh Alg9 Sptb Alg1 Lman2 Alg2 Sec16a Sec22c Dolpp1 Dctn2 Dolk Dctn3 Dync1h1 Gfpt1 St6galnac1 Srd5a3 St6galnac2 St8sia1 Slc35a1 Derl1 St3gal1 St3gal2 Slc35c1 St8sia5 St8sia4 St3gal5 St3gal6 SIGNALING BY VEGF%REACTOME DATABASE ID RELEASE 59%194138 Signaling by VEGF Akap9 Ppp2r1a Prkcb Mapkapk3 Wasf2 Wasf3 Wasf1 Ctnna1 Cybb Cyba Rac1 Pak1 Csf2 Ptk2b Jak1 Nrp1 Nrp2 Nckap1l Vegfa Itgav Abi1 Abi2 Vav2 Nckap1 Cyfip1 Cyfip2 Frs2 Nras Frs3 Rasgrf1 Psmf1 Raf1 Psme4 Ncf4 Il5ra Fgf1 Il17rd Ncf2 Fgf2 Cnksr1 Csk Ncf1 Cnksr2 Erbb2 Fgf9 Ptk2 Fgf7 Psme3 Fgf6 Fgf4 Fgf3 Ppp5c Ranbp9 Rock1 Rock2 Ppp2cb Shc1 Lamtor2 Nrg2 Hspb1 Ppp2ca Shc3 Nrg1 Akt2 Akt3 Shc2 Psma7 Artn Nrtn Plcg1 Brap Nck2 Psmb5 Psmb4 Ubc Nrg3 Psmb7 Nrg4 Psmb6 Psmb2 Psmb3 Psmb1 Nck1 Mapk3 Akt1 Mapk1 Ksr1 Ptpra Dusp16 Dusp10 Map3k11 Paqr3 Psme2 Psme1 Ncam1 Sos1 Rictor Braf Psmb10 Apbb1ip Ahcyl1 Vegfb Vegfc Psmb11 Figf Csf2rb2 Rapgef2 Csf2ra Flt4 Pgf Dock1 Prkcd Actn2 Nf1 Pdgfrb Pdgfra Mlst8 Kbtbd7 Prkca Vav1 Il2rg Arrb2 Egfr Arrb1 Mtor Ret Rhoa Vwf Elmo1 Elmo2 Mapkapk2 Sptan1 Pspn Map2k1 Rbx1 Fgg Map2k2 Cul3 Psmd12 Pdgfb Psmd11 Rasgef1a Psmd14 Rasa3 Rasa4 Psmd13 Psmd10 Il2 Rasa2 Rasa1 Nefl Spred3 Kit Spred2 Kdr Grin2a Spred1 Spta1 Il5 Flt1 Sptbn4 Ppp2r1b Ywhab Kras Gdnf Pak3 Shfm1 Pak2 Itpr1 Irs2 Syngap1 Hbegf Irs1 Il3ra Btc Il2ra Il2rb Itpr3 Angpt1 Itpr2 Trib3 Psmc6 Egf Fgf23 Psmc5 Fgf22 Mark3 Psmc2 Fgf20 Psmd2 Dab2ip Nos3 Prkacb Tek Psmb9 Hsp90aa1 Psmb8 Araf Hras Sphk1 Grin1 Shb Ppp2r5e Mapkap1 Dlg4 Ppp2r5c Ppp2r5d Ppp2r5a Psmc1 Psmc4 Psmc3 Pik3cb Sptbn2 Axl Sptbn1 Sh2d2a Itgb3 Fyn Phb Grin2c Rasgrp4 Rasgrp3 Pebp1 Cav1 Ppp2r5b Rasgrp1 Tln1 Pik3ca Fga Fgb Grin2d Prkaca Grin2b Sptb Prr5 Vav3 Hgf Gfra2 Gfra3 Jup Ctnnd1 Gfra4 Ereg Jak2 Pea15a Itga2b Rap1a Jak3 Cdh5 Wdr83 Camk2d Rap1b Camk2a Fgfr4 Camk2b Psma5 Rasal3 Pxn Rasal2 Psma4 Psma3 Psma6 Vcl Baiap2 Camk2g Psma2 Psma1 Brk1 Gfra1 Psmd9 Dusp7 Iqgap1 Fgf16 Dusp6 Dusp9 Fgf15 Dusp8 Klb Fgf18 Them4 Psmd1 Met Prkcz Fn1 Bcar1 Mapk11 Rasal1 Dusp1 Mapk13 Psmd3 Mapk12 Psmd4 Mapk14 Pdpk1 Psmd6 Psmd5 Dusp2 Psmd7 Crk Pik3r1 Dusp5 Psmd8 Fgf10 Pik3r2 Dusp4 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS%REACTOME%R-HSA-390471.1 Association of TriC CCT with target proteins during biosynthesis Cct5 Gapdhs Tcp1 Wrap53 Cct8 Xrn2 Cct4 Cct7 Fkbp9 Stat3 Fbxw10 Sphk1 Ccne1 Fbxo4 Skiv2l Fbxo6 Ccne2 Fbxw2 Dcaf7 Fbxw5 Fbxw4 Fbxw9 Fbxw7 Cct2 Cct6b Usp11 Cct3 Trp53 Ap3m1 Nop56 Arfgef2 Kif13a Gba Fbxl5 Fbxl3 Lonp2 Hdac3 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM%REACTOME%R-HSA-1793185.1 Chondroitin sulfate dermatan sulfate metabolism Agrn Chst3 Chsy1 Hexa Chpf Bgn Dcn Chsy3 Bcan Chst15 B3gat3 B3gat2 B3gat1 Cspg4 Cspg5 Hexb B4galt7 Chst13 Csgalnact1 Csgalnact2 Ncan Dse Xylt2 Chst12 Hyal1 Vcan Hyal3 Chst7 Xylt1 Chst11 Sdc3 Dsel Chst14 Sdc4 Gpc6 Sdc2 Gpc3 Ust Sdc1 Gpc5 Gpc2 Gpc4 Arsb Ids B3galt6 Idua Hspg2 Gpc1 KETONE BODY METABOLISM%REACTOME DATABASE ID RELEASE 59%74182 Ketone body metabolism Hmgcs2 Bdh2 Bdh1 Acat1 Aacs Hmgcll1 Hmgcl Oxct1 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL%REACTOME DATABASE ID RELEASE 59%1855167 Synthesis of pyrophosphates in the cytosol Ippk Ip6k1 Itpk1 Ppip5k2 Ppip5k1 Nudt10 Nudt4 Nudt3 Ip6k3 Nudt11 MITOTIC METAPHASE ANAPHASE TRANSITION%REACTOME%R-HSA-68881.2 Mitotic Metaphase Anaphase Transition Fbxo5 Plk1 ACTIVATION OF RAS IN B CELLS%REACTOME DATABASE ID RELEASE 59%1169092 Activation of RAS in B cells Kras Rasgrp3 Nras Rasgrp1 Hras CD28 CO-STIMULATION%REACTOME DATABASE ID RELEASE 59%389356 CD28 co-stimulation Akt2 Akt3 Map3k14 Cd80 Mlst8 Yes1 Vav1 Lyn Mapkap1 Mtor Akt1 Fyn Rac1 Pak1 Them4 Pak3 Pak2 Map3k8 Pik3ca Rictor Pdpk1 Lck Pik3r3 Pik3r1 Prr5 Grap2 Pik3r2 Trib3 Cd86 REMOVAL OF AMINOTERMINAL PROPEPTIDES FROM GAMMA-CARBOXYLATED PROTEINS%REACTOME DATABASE ID RELEASE 59%159782 Removal of aminoterminal propeptides from gamma-carboxylated proteins Furin Proz F10 Pros1 Gas6 F9 F2 F7 Proc NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%R-HSA-5250941.1 Negative epigenetic regulation of rRNA expression Mbd2 Smarca5 Suv39h1 Hist2h3c1 Sap30l Polr1a Znrd1 Polr1e Hdac1 H2afj H2afb2 Polr2f Polr2e Polr2h Sirt1 Hdac2 Tbp Mnat1 Ubtf Sap30 Polr1b Suds3 Polr2k Arid4b Rrp8 Hist2h2be Hist3h2ba Sap30bp Polr1d Sap130 Polr1c Hist2h2ac Ttf1 Gtf2h1 H3f3b H3f3a Gtf2h2 Hist1h2bg Gtf2h5 Hist1h2bh Gm10094 Gtf2h4 Dnmt3b Cd3eap Hist1h2bp Hist1h2bm Hist1h2bj Hist1h2bb Gtf2h3 Ercc3 Sin3b Baz2a H2afz Taf1d Taf1c H2afx Taf1b Taf1a Ercc2 Dnmt1 Hist2h2aa1 Hist1h3d Ccnh Hist1h2ak Hist1h2ag Sin3a Cdk7 Hist1h2ah BETA OXIDATION OF MYRISTOYL-COA TO LAUROYL-COA%REACTOME%R-HSA-77285.2 Beta oxidation of myristoyl-CoA to lauroyl-CoA Acadl Hadhb Hadha SIGNALING BY GPCR%REACTOME%R-HSA-372790.2 Signaling by GPCR Prkcb Gpr31b Rps6ka3 Rps6ka2 Rps6ka1 Fzd6 Vav2 Wnt3a Fzd4 Fzd5 Fzd8 F2rl3 F2rl2 Csk Pla2g4a Gna11 Gna12 F2r Gnaq Gna15 F2 Gna13 Gna14 Gab2 Smo Ptch1 Pde3b Gpr143 Avp Avpr1a Avpr2 Avpr1b Gngt1 Gng7 Adcyap1r1 Gng4 Adcyap1 Gcg Gngt2 Glp1r Gng10 Gcgr Prkar2b Gng11 Gng13 Gng12 Gnb2 Gnb1 Gnb3 Gnb5 Ghrhr Gnb4 Ghrh Prkaca Glp2r Gng8 Sct Gip Gng3 Gng2 Gipr Psap Ppp3cc Ppp1r1b C3 Gnao1 Ppp1ca Mmp3 Ppp3cb Rac1 Ppp3ca Ppp3r1 Adcy7 Adcy6 Adcy5 Adcy4 Adcy3 Adcy2 Prkar2a Adcy1 Frs2 Nras Frs3 Rasgrf1 Adcy9 Psmf1 Pf4 Adcy8 Raf1 Psme4 Il5ra Fgf1 Il17rd Fgf2 Cnksr1 Cnksr2 Erbb2 Fgf9 Ptk2 Fgf7 Psme3 Fgf6 Fgf4 Fgf3 Ppp5c Prkar1a Prkar1b Ranbp9 Ppp2cb Shc1 Lamtor2 Nrg2 Ppp2ca Shc3 Nrg1 Akt2 Akt3 Shc2 Psma7 Artn Nrtn Brap Psmb5 Psmb4 Ubc Nrg3 Psmb7 Grm1 Nrg4 Psmb6 Grm5 Psmb2 Psmb3 Psmb1 Mapk3 Akt1 Mapk1 Ksr1 Ptpra Dusp16 Dusp10 Map3k11 Paqr3 Pde1c Pde1b Psme2 Pde1a Psme1 Ncam1 Sos1 Braf Psmb10 Apbb1ip Tas1r3 Ahcyl1 Tas1r2 Tas1r1 Psmb11 Csf2rb2 Rapgef2 Csf2ra Rhoa Arhgef6 Akap13 Ucn Ect2 Arhgef10l Sos2 Trio Mcf2 Mcf2l Arhgef7 Arhgef3 Arhgef4 Arhgef1 Arhgef2 Arhgef9 Ucn3 Fzd9 Prex1 Crhbp Fzd2 Fzd10 Fzd1 Fzd3 Adgre1 Fzd7 Ptch2 Itsn1 Olfr1156 Olfr1157 Olfr1052 Olfr1155 Olfr631 Olfr1357 Olfr635 Olfr1352 Olfr1162 Olfr18 Olfr1356 Gal Gpr27 Gpr25 Olfr16 Olfr17 Gpr4 Oxt Olfr1093 Htr5a Npy1r Kiss1r Gpsm1 Olfr1094 Rho F2rl1 Grpr Ptgdr Rgr Adm2 Mc5r Ptgfr Ntsr1 Ntsr2 Mapk7 Sucnr1 Ghsr Uts2b Npy5r Uts2r Taar8b Npy4r Taar1 Taar2 Taar5 Taar6 Pnoc Taar9 Npy2r Casr Olfr231 Ptgdr2 Adora2b Trh Adora2a Opn1sw Adora3 Mc2r Adora1 Olfr919 Fshr Adrb2 Fshb C5ar1 Rhog Adrb1 Edn1 Rhob Adrb3 Rock1 Edn3 Rhoc Edn2 Rock2 Gpha2 Mc1r Olfr222 Olfr220 Ptgir Olfr221 Lpar5 Oxgr1 P2ry13 P2ry12 P2ry14 P2ry10 Olfr421-ps1 Olfr229 Ramp1 Brs3 Ccr9 Ccr8 Ccr7 Ccr6 Ccr4 Ccr3 Mc3r Calcrl Lpar6 Mc4r Ccr10 Ramp2 Ramp3 Vipr2 Olfr211 Vipr1 Cx3cl1 Ackr4 Ccl2 Ccl1 Cx3cr1 Ccrl2 Olfr685 Olfr684 Prkcd Olfr683 Prkce Reep5 Actn2 Reep4 Nf1 Reep3 Prkcg Pth2r Tas2r118 Pdgfrb Tas2r126 Olfr410 Pdgfra Olfr411 Olfr412 Tas2r121 Tas2r120 Kbtbd7 Olfr414 Prkca Reep1 Vav1 Dgkb Il2rg Npff Arrb2 Olfr677 Egfr Dgka Pde10a Arrb1 Olfr1311 Olfr478 Ret Olfr675 Olfr687 Adrbk1 Reep2 Vwf Reep6 Tas2r119 Olfr402 Olfr681 Dgke Dgkg Iapp Gper1 Pth1r Tas2r108 Olfr175-ps1 Ccl25 Olfr821 Ccl28 Galr2 Htr2a Agtr2 Olfr32 Htr2b Tas2r107 Htr2c Olfr1385 Rrh Olfr419 Rasgrp2 Olfr417 Olfr809 Olfr808 Olfr692 Olfr691 Olfr429 Olfr430 Olfr825 Olfr298 Olfr420 Ihh Shh Olfr288 Dhh Agtr1a Olfr832 Olfr1500 Pspn Htr1d Map2k1 Olfr20 Rbx1 Olfr24 Olfr1509 Pmch Fgg Olfr1505 Map2k2 Htr1f Olfr57 Cul3 Psmd12 Olfr55 Gpr18 Pdgfb Psmd11 Qrfp Hcrtr1 Hcrtr2 Rasgef1a Olfr1512 Olfr1511 Psmd14 Htr7 Olfr31 Rasa3 Galr1 Rasa4 Psmd13 Htr6 Psmd10 Fpr3 Olfr1102 Il2 Htr4 Rasa2 Olfr1100 Rasa1 Pomc Nefl Gpr17 Spred3 Kit Fpr2 Olfr1104 Spred2 Htr1b Grin2a Olfr26 Gpr15 Spred1 Htr1a Il5 P2ry1 Ppp2r1b Rgs4 Ywhab P2ry2 Rgs5 Rgs7 Rgs6 Kras Rgs9 Rgs8 C3ar1 Gpr55 Olfr1360 Gdnf Olfr618 Olfr11 Shfm1 Gpr20 Olfr15 Olfr13 Olfr1123 Itpr1 Olfr43 Olfr44 Irs2 Olfr47 Olfr1396 Syngap1 Gast Olfr1111 Hbegf Npffr1 Irs1 Cck Il3ra Npffr2 Btc Il2ra Gpr45 Il2rb Rgs1 P2ry6 Itpr3 Rgs2 Angpt1 Rgs3 Itpr2 P2ry4 Psmc6 Grp Egf Rtp2 Fgf23 Abhd12 Psmc5 Tbxa2r Fgf22 Crhr2 Mark3 Crhr1 Psmc2 Tas2r137 Fgf20 Tas2r136 Psmd2 Tas2r135 Dab2ip Sst Prkacb Nmb Tek Ackr3 Psmb9 Tas2r131 Psmb8 Tas2r130 Araf Tas2r138 Hras Tas2r139 Grin1 Nmu Ppp2r5e Chrm3 Chrm2 Dlg4 Chrm1 Ppp2r5c Trhr Nms Ppp2r5d Gprc6a Ppp2r5a Pik3r6 Psmc1 Pik3r5 Psmc4 Kiss1 Psmc3 Chrm5 Pik3cb Crh Chrm4 Pik3cd Tas2r140 Calcr Itgb3 Tas2r144 Fyn Gnai2 Creb1 Gnai1 Phb Olfr376 Xcr1 Grin2c S1pr5 Gnai3 Olfr370 Rasgrp4 Olfr372 Rasgrp3 S1pr2 S1pr3 Pebp1 Camk4 S1pr1 Ppp2r5b S1pr4 Ngef Sstr2 Rasgrp1 Sstr1 Tln1 Opn3 Pik3ca Opn4 Arhgef26 Sstr5 Fgd2 Npbwr1 Net1 Sstr3 Sstr4 Fgd4 Ppy Cort Fgd1 Fga Opn5 Fgd3 Fgb Npb Grin2d Lhcgr Ffar4 Npy Grin2b Arhgef17 Npw Arhgef10 Nmbr Vav3 Rtp4 Rtp3 Hgf Nps Rtp1 Gfra2 Plekhg5 Olfr448 Gfra3 Arhgef19 Olfr648 Arhgef16 Olfr447 Gfra4 Arhgef15 Olfr263 Ereg Olfr444 Abr Jak2 Olfr646 Arhgef18 Pea15a Dgkq Plekhg2 Itga2b Olfr1309 Arhgef40 Rap1a Lpar3 Jak3 Lpar4 Wdr83 Lpar1 Camk2d Lpar2 Rap1b Dgkh Camk2a Olfr446 Fgfr4 Olfr267 Camk2b Dgki Psma5 Arhgef38 Gcat Arhgef39 Rasal3 Olfr365 Olfr362 Rasal2 Olfr101 Psma4 Ltb4r2 Psma3 Olfr368 Psma6 Oprd1 Arhgef37 Ltb4r1 Vcl Olfr110 Camk2g Pdyn Psma2 Cxcl16 Psma1 Cxcl13 Gfra1 Olfr109 Pthlh Cxcl12 Cxcl11 Psmd9 Olfr669 Tiam2 Dusp7 Olfr464 Tiam1 Iqgap1 Gpr68 Fgf16 Gpr65 Dusp6 Olfr666 Dusp9 Olfr870 Fgf15 Olfr874 Dusp8 Olfr867 Klb Olfr658 Fgf18 Kalrn Olfr453 Cnr2 Psmd1 Abhd6 Met Olfr878 Fn1 Olfr243 Olfr460 Rasal1 Olfr463 Dusp1 Gpr83 Psmd3 Olfr854 Psmd4 Olfr272 Pdpk1 Olfr275 Psmd6 Olfr270 Psmd5 Olfr273 Dusp2 Cnr1 Pik3r3 Olfr452 Psmd7 Dgkz Pde11a Pik3r1 Olfr449 Dusp5 Olfr640 Psmd8 Olfr641 Fgf10 Adrbk2 Pik3r2 Gpr84 Dusp4 Olfr853 Olfr1256 Olfr1259 Trpc6 Ffar3 Pde4d Pde4c Olfr1258 C5ar2 Gpr150 Akap9 Olfr1193 Nts Oprk1 Ppp2r1a Olfr1014 Rxfp1 Rxfp2 Gpbar1 Olfr1019 Olfr1020 Arhgef25 Rxfp4 Rxfp3 Ptger3 Olfr1023 Saa3 Ptger4 Olfr1022 Cxcl2 Ptger1 Ptger2 Olfr1029 Olfr1032 Olfr1031 Cxcl9 Cxcl5 Vip Wnt11 Olfr796 Wnt10a Grm7 Wnt3 Grm8 Wnt10b Grm2 App Wnt6 Grm3 Wnt4 Grm4 Wnt9b Hc Wnt9a Olfr504 Olfr508 Olfr1288 Olfr780 Wnt7a Olfr782 Wnt2b Olfr786 Wnt7b Olfr788 Olfr516 Wnt16 Gpr132 Olfr518 Prok1 Olfr1469 Csf2 Mchr1 Prok2 Hebp1 Olfr1461 Olfr1264 Wnt8a Olfr1265 Wnt8b Trpc3 Olfr1451 Ffar2 Wnt5a Olfr1252 Wnt1 Ffar1 Trpc7 Wnt2 Olfr1006 Ccl5 Cxcr1 Daglb Jak1 Olfr63 Fpr1 Pde7b Olfr64 Olfr65 Ccr1 Olfr68 Prokr1 Agt Oprl1 Prokr2 Dagla Anxa1 Ptafr Cxcr2 Cxcr3 Nmur1 Nmur2 Olfr71 Cxcl3 Cckar Cxcl1 Olfr76 Pde8a Pde8b Olfr78 Pth Calca Ccl20 Ccr2 Cxcr6 Ccr5 Olfr1008 Olfr73 Cxcr4 Cxcl10 Cxcr5 Mgll Pde3a Apln Olfr1046 Olfr1047 Pde2a Olfr1173 Pth2 Olfr1034 Adm Gnat1 Gnat2 Gnat3 Olfr1044 Olfr1045 Pde4a Pde4b Olfr96 Hrh3 Olfr91 Olfr95 Pyy Hrh1 Hrh2 Hrh4 Olfr66 Hcar1 Cckbr Pde7a Aplnr Olfr90 Hcar2 Oprm1 Rgs17 Rgs18 Olfr705 Olfr583 Rgs14 Olfr980 Rgs19 Olfr982 Olfr1206 Olfr589 Olfr1209 Olfr309 Gnaz Rgs10 Rgs12 Rgs11 Qrfpr Olfr3 Olfr314 Olfr173 Rgs21 Rgs22 Olfr2 Rgs20 Rgs16 Olfr985 Rgs13 Olfr986 Olfr310 Olfr315 Olfr984 Olfr706 Olfr159 Olfr728 Olfr727 Olfr729 Olfr722 Olfr723 Olfr1414 Olfr720 Olfr1423 Olfr1425 Olfr1416 Olfr520 Olfr152 Gnal Gabbr2 Gabbr1 Olfr1408 Olfr160 Olfr305 Olfr165 Olfr164 Olfr1404 Olfr586 Olfr308 Olfr167 Olfr714 Olfr166 Olfr713 Olfr168 Olfr993 Olfr715 Olfr1204 Gm4461 Cysltr1 Adra1a Adra1b Penk Adra1d Grk6 Grk5 Mtnr1a Gpr176 Olfr1234 Mtnr1b Plcb1 Plcb2 Uts2 Hcrt Npsr1 Olfr790 Adra2a Olfr1211 Adra2c Adra2b Olfr1497 Olfr1496 Olfr1490 Olfr1494 Tacr2 Tacr3 Bdkrb1 Tacr1 Cysltr2 Bdkrb2 Kng2 Tshr Rgsl1 Olfr198 Gnrh1 Ppbp Olfr979 Olfr978 Olfr183 Olfr180 Olfr569 Olfr568 Olfr974 Olfr592 Olfr186 Olfr187 Insl5 Olfr1240 Plcb4 Plcb3 Olfr574 Olfr571 Pik3cg Insl3 Olfr577 Olfr578 Olfr576 Ppan Olfr196 Tshb Olfr193 Oxtr Sptan1 Olfr323 Olfr322 Olfr145 Olfr735 Olfr1426 Olfr1428 Ednra Ednrb Rln3 Rln1 Olfr1420 Olfr730 Olfr732 Olfr147 Olfr733 Olfr734 Olfr137 Olfr350 Olfr745 Olfr744 Prkcq Olfr357 Olfr749 Olfr351 Xcl1 Olfr558 Olfr557 Olfr556 Olfr554 Olfr1434 Spta1 Olfr552 Prkch Sptbn4 Olfr750 Olfr125 Arhgef11 Drd4 Olfr348 Arhgef12 Drd5 Drd2 Drd3 Drd1 Olfr354 Opn1mw Olfr355 Tac2 Plxnb1 Olfr1444 Olfr1445 Tac1 Gnrhr Rac2 Cdk5 Cga Lhb Sptbn2 Sptbn1 Adgre5 Prlhr Xk Gpr183 Ackr1 Gpr35 Ece2 Ece1 Gpr37l1 Lppr3 Lppr2 Kel Prlh Nln Lppr1 Lppr5 Lppr4 Gpr37 Sptb ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS%REACTOME DATABASE ID RELEASE 59%2122948 Activated NOTCH1 Transmits Signal to the Nucleus Adam10 Dner Dlk1 Dtx2 Dtx4 Dtx1 Arrb2 Ubc Cntn1 Itch Notch1 Arrb1 Aph1b Psen2 Ncstn Mib2 Neurl1a Neurl1b Numb Adam17 Jag2 Mib1 Dll1 Dll4 Jag1 POLYMERASE SWITCHING%REACTOME DATABASE ID RELEASE 59%69091 Polymerase switching Pold1 Pold2 Pold3 Pcna Pold4 Prim1 Rfc5 Rfc3 Rfc2 Pola1 Pola2 Rfc4 Prim2 Rfc1 STABILIZATION OF P53%REACTOME DATABASE ID RELEASE 59%69541 Stabilization of p53 Psmc6 Psmc5 Psmc2 Psmd2 Psmb9 Psmb8 Psmf1 Psme4 Mdm4 Psmc1 Psmc4 Psmc3 Psme3 Chek2 Atm Psmd12 Psma7 Psmd11 Psmd14 Psma5 Psmb5 Psmb4 Psmd13 Ubc Psmd10 Psma4 Psma3 Psmb7 Psma6 Psmb6 Psmb2 Psmb3 Psma2 Psmb1 Psma1 Psmd9 Trp53 Psmd1 Shfm1 Psme2 Psme1 Rfwd2 Psmd3 Psmd4 Psmb10 Mdm2 Psmd6 Psmd5 Psmd7 Psmb11 Psmd8 INTERLEUKIN-12 SIGNALING%REACTOME%R-HSA-447115.1 Interleukin-12 signaling Il12b Il12rb1 Il12a Il12rb2 NUCLEAR ENVELOPE REASSEMBLY%REACTOME DATABASE ID RELEASE 59%2995410 Nuclear Envelope Reassembly Emd Ankle2 Ppp2r2a Ppp2ca Banf1 Vrk1 Lmnb1 Ppp2r1a Lemd3 Lemd2 HDL-MEDIATED LIPID TRANSPORT%REACTOME%R-HSA-194223.2 HDL-mediated lipid transport Abca1 Alb Hdlbp Apoc2 Apoc3 Abcg1 Prkacb Zdhhc8 Amn A2m Cubn Prkaca Lcat Apoe Apoa1 COSTIMULATION BY THE CD28 FAMILY%REACTOME DATABASE ID RELEASE 59%388841 Costimulation by the CD28 family Ppp2r1a Mlst8 Vav1 Ppp2r5e Mapkap1 Ppp2r5c Csk Mtor Ppp2r5d Cd274 Ppp2r5a Fyn Rac1 Btla Pak1 Ppp2r5b Map3k8 Pik3ca Ctla4 Prr5 Cd86 Ppp2cb Ppp2ca Akt2 Akt3 Map3k14 Cd80 Yes1 Lyn Akt1 Ppp2r1b Them4 Pak3 Pak2 H2-Aa Rictor Cd3d Cd3e Pdpk1 H2-Eb1 Lck Pdcd1lg2 Tnfrsf14 Icosl Cd4 Ptpn6 Pik3r3 Pik3r1 Pdcd1 Ptpn11 Grap2 Cd3g Pik3r2 Trib3 METALLOTHIONEINS BIND METALS%REACTOME DATABASE ID RELEASE 59%5661231 Metallothioneins bind metals Mt2 Mt4 Mt1 Mt3 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS%REACTOME DATABASE ID RELEASE 59%1222352 Latent infection of Homo sapiens with Mycobacterium tuberculosis Ltf SUMO IS PROTEOLYTICALLY PROCESSED%REACTOME%R-HSA-3065679.1 SUMO is proteolytically processed Senp1 Senp2 Sumo3 Senp5 TOXICITY OF BOTULINUM TOXIN TYPE C (BONT C)%REACTOME DATABASE ID RELEASE 59%5250971 Toxicity of botulinum toxin type C (BoNT C) Stx1b Snap25 Stx1a IRAK4 DEFICIENCY (TLR2 4)%REACTOME%R-HSA-5603041.1 IRAK4 deficiency (TLR2 4) Cd36 Irak4 Tlr1 Tirap Tlr4 Myd88 Tlr2 Btk Tlr6 Ly96 Cd14 PEPTIDE HORMONE METABOLISM%REACTOME DATABASE ID RELEASE 59%2980736 Peptide hormone metabolism Grp Gzmf Crhr2 Gcg Ucn Mme Gata4 Cga Atp6ap2 Lhb Klf4 Ins2 Dpp4 Anpep Cpb2 Gng13 Slc30a5 Slc30a8 Sec11c Cpe Sec11a Ero1l Cdx2 Gnb3 Myo5a Rab27a Cpb1 Slc30a6 2010111I01Rik Slc30a7 Ache Lep Ffar4 Fshb Gpr119 Mboat4 Pcsk1 Gip Spcs1 Kif5c Spcs2 Pcsk2 Ffar1 Spcs3 Pax6 Ace2 Isl1 Enpep Exoc3 Exoc4 Myrip Tmem27 Igf1 Ero1lb Agt Exoc1 Exoc5 Exoc6 Cpa3 Exoc8 Exoc7 Exoc2 Cpn1 Pomc Inha Inhba Inhbb Pla2g7 Ctsz Bche Inhbc Ace Kif5a Inhbe Ctsg Kif5b Cma1 Gnat3 Ctsd Vamp2 Tshb Tcf7l2 Stx1a DEFECTIVE ABCA3 CAUSES PULMONARY SURFACTANT METABOLISM DYSFUNCTION TYPE 3 (SMDP3)%REACTOME DATABASE ID RELEASE 59%5683678 Defective ABCA3 causes pulmonary surfactant metabolism dysfunction type 3 (SMDP3) Sftpb Sftpc Sftpa1 Sftpd INTEGRATION OF ENERGY METABOLISM%REACTOME DATABASE ID RELEASE 59%163685 Integration of energy metabolism Akap5 Prkaa2 Ppp2r1a Prkca Mlx Arl2 Arl2bp Fasn Ins2 Slc25a4 Mlxipl Adipor2 Ffar1 Adipor1 Adipoq Acacb Acaca Cacna1e Cacna1a Ppp2r1b Itpr1 Marcks Syt5 Itpr3 Itpr2 Pfkfb1 Gngt1 Adcy7 Prkag2 Gng7 Adcy6 Adcy5 Gng4 Adcy4 Adcy3 Gcg Adcy2 Gngt2 Prkar2a Glp1r Adcy1 Prkacb Gng10 Gcgr Adcy9 Adcy8 Acly Rapgef4 Chrm3 Rapgef3 Prkar2b Kcnb1 Kcns3 Kcng2 Ppp2r5d Kcnc2 Slc2a2 Slc2a1 Gnai2 Gnai1 Tkt Taldo1 Gng11 Gng13 Gng12 Gnb2 Gnb1 Gnb3 Prkar1a Gnb5 Prkar1b Gnb4 Gna11 Prkaca Gng8 Gnaq Gna15 Slc25a5 Gng3 Gng2 Gna14 Ppp2cb Ppp2ca Rap1a Plcb1 Plcb2 Snap25 Stxbp1 Adra2a Adra2c Stk11 Iqgap1 Prkab2 Cacnb2 Cacnb3 Cacna2d2 Cacna1c Cacna1d Agpat1 Kcnj11 Abcc8 Plcb3 Ahcyl1 Vamp2 Stx1a FIBRONECTIN MATRIX FORMATION%REACTOME DATABASE ID RELEASE 59%1566977 Fibronectin matrix formation Itgb1 Fn1 Itga5 MTB IRON ASSIMILATION BY CHELATION%REACTOME DATABASE ID RELEASE 59%1222449 Mtb iron assimilation by chelation Ltf PECAM1 INTERACTIONS%REACTOME DATABASE ID RELEASE 59%210990 PECAM1 interactions Fyn Yes1 Lyn Lck Ptpn6 Pecam1 Inpp5d Itgav Ptpn11 Plcg1 Itgb3 DEREGULATED CDK5 TRIGGERS MULTIPLE NEURODEGENERATIVE PATHWAYS IN ALZHEIMER'S DISEASE MODELS%REACTOME DATABASE ID RELEASE 59%8862803 Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models App Fasl Cdc25c Cdc25b Jun Prdx2 Lmnb1 Prdx1 Ywhae Bcl2l11 Sod2 Capn1 Golga2 Cast Capns1 Capn2 Capns2 Cdc25a Foxo3 Cdk5 Cdk5r1 PYRIMIDINE METABOLISM%REACTOME%R-HSA-73848.1 Pyrimidine metabolism Tymp Upp2 Upp1 Agxt2 Nt5m Umps Tk1 Cad Hdhd1a Uck1 Uck2 Dhodh Cda Dck Nt5c1a Tyms Nt5e Nt5c Dctd Tk2 Upb1 Dpyd Dpys TNF SIGNALING%REACTOME DATABASE ID RELEASE 59%75893 TNF signaling Casp8 Fadd Tnf Chuk Tradd Ripk1 Tnfaip3 Usp21 Bag4 Xiap Tax1bp1 Ubc Otulin Otud7b Usp2 Usp4 Clip3 Cyld Traf1 Traf2 Sharpin Map3k7 Smpd3 Gnb2l1 Nsmaf Birc3 Birc2 Tab1 Tab2 Tab3 Ikbkb Rbck1 Sppl2a Sppl2b Rnf31 Ikbkg Tnfrsf1a Adam17 Smpd2 HIV TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 59%167161 HIV Transcription Initiation Gtf2h5 Gtf2a1 Taf13 Gtf2h4 Taf11 Gtf2a2 Gtf2b Gtf2h3 Ercc3 Taf1 Taf2 Taf4b Taf7 Taf4a Taf12 Taf5 Taf6 Taf3 Ercc2 Polr2i Polr2f Polr2j Polr2e Gtf2e1 Polr2h Tbp Gtf2e2 Polr2c Mnat1 Polr2d Ak6 Polr2b Taf9b Taf9 Polr2k Polr2g Ccnh Cdk7 Polr2a Gtf2h1 Gtf2f1 Gtf2h2 Gtf2f2 TELOMERE EXTENSION BY TELOMERASE%REACTOME DATABASE ID RELEASE 59%171319 Telomere Extension By Telomerase Dkc1 Nhp2 Wrap53 Tert Ruvbl2 Ruvbl1 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE%REACTOME%R-HSA-204998.1 Cell death signalling via NRAGE, NRIF and NADE Akap13 Ywhae Itgb3bp Ect2 Vav1 Bad Aph1b Rac1 Mapk8 Ngef Arhgef10l Sos2 Arhgef26 Fgd2 Net1 Fgd4 Fgd1 Fgd3 Trio Arhgef17 Arhgef10 Vav3 Gna13 Plekhg5 Arhgef19 Arhgef16 Arhgef15 Abr Arhgef18 Plekhg2 Arhgef40 Arhgef38 Casp3 Arhgef39 Mcf2 Ubc Mcf2l Arhgef37 Tiam2 Tiam1 Ngf Arhgef7 Arhgef11 Aatf Arhgef12 Traf6 Arhgef3 Psen2 Arhgef4 Kalrn Arhgef1 Ncstn Arhgef2 Vav2 Sqstm1 Bcl2l11 Ngfrap1 Arhgef9 Sos1 Prex1 Arhgef6 Casp2 Itsn1 Maged1 Ngfr APC TRUNCATION MUTANTS HAVE IMPAIRED AXIN BINDING%REACTOME%R-HSA-5467337.1 APC truncation mutants have impaired AXIN binding Ppp2r1b Ppp2cb Apc Axin1 Ppp2ca Amer1 Csnk1a1 Gsk3b Ppp2r1a Ppp2r5b Ppp2r5e Ppp2r5c Ppp2r5d Ppp2r5a POSITIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME DATABASE ID RELEASE 59%5250913 Positive epigenetic regulation of rRNA expression Smarca5 Actb Ercc6 Hist2h3c1 Polr1a Znrd1 Polr1e Hdac1 Baz1b Rbbp4 Chd3 Chd4 H2afj H2afb2 Polr2f Polr2e Polr2h Hdac2 Tbp Polr1b Mbd3 Polr2k Hist2h2be Hist3h2ba Ep300 Polr1d Cbx3 Polr1c Mta1 Hist2h2ac Ttf1 Kat2b Kat2a H3f3b Mta3 H3f3a Ddx21 Hist1h2bg Hist1h2bh Cd3eap Hist1h2bp Hist1h2bm Hist1h2bj Rbbp7 Hist1h2bb Mta2 Sf3b1 H2afz Taf1d Taf1c H2afx Taf1b Taf1a Dek Hist2h2aa1 Gsk3b Gatad2a Gatad2b Hist1h3d Ehmt2 Hist1h2ak Hist1h2ag Mybbp1a Hist1h2ah INTEGRIN CELL SURFACE INTERACTIONS%REACTOME%R-HSA-216083.1 Integrin cell surface interactions Agrn Itga6 Itga7 Itga8 Itgb1 Lum Fbn1 Icam4 Icam5 Itgb3 Spp1 Itga3 F11r Col4a3 Col4a2 Col4a4 Col4a1 Fga Fgb Thbs1 Bsg Itgb8 Icam2 Cdh1 Col16a1 Fgg Itga2b Itga4 Col9a1 Col9a2 Col9a3 Icam1 Itgb7 Itgb2 Itgal Itgam Itgav Pecam1 Itgae Itgad Kdr Itga11 Jam2 Jam3 Tnc Col23a1 Vcam1 Dag1 Itgax Fn1 Itgb6 Itgb5 Vtn Ibsp Itga1 Col13a1 Itga2 Cd44 Itga9 Comp Itga10 Itga5 Hspg2 Cd47 Col18a1 SIGNALING BY NOTCH%REACTOME%R-HSA-157118.1 Signaling by NOTCH Mfng Hdac4 Hdac5 Dner Dlk1 Rfng Lfng Dtx2 Dtx4 Dtx1 Cdk8 Arrb2 Arrb1 Sel1l Hdac1 Poglut1 Maml2 Pofut1 Aph1b Hif1a Maml1 Hdac2 Jun Mdk Mib2 Hdac10 Neurl1a Neurl1b Hey1 Hdac11 Hey2 Fcer2a Ep300 Hdac7 Hdac6 Hdac9 Hdac8 Hes5 Kat2b Mib1 Kat2a Heyl Hes1 Rbx1 Tbl1x St3gal4 Cntn1 Notch4 Ago2 Ago1 Tnrc6c Gzmb Tnrc6b Tle1 Tnrc6a Notch3 Tle4 Ago4 Ago3 Notch2 Tle2 Numb Rab6a Tbl1xr1 Ccnc Notch1 Skp1a E2f1 Cul1 Tfdp2 Tfdp1 Ccnd1 Creb1 Ncor1 Ncor2 E2f3 Furin Crebbp B4galt1 Rbpj Adam10 Maml3 Ubc Itch Myc Atp2a1 Atp2a3 Trp53 Atp2a2 Psen2 Ncstn Mamld1 Adam17 Jag2 Dll1 Dll4 St3gal6 Hdac3 Jag1 Mov10 APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS%REACTOME%R-HSA-351906.1 Apoptotic cleavage of cell adhesion proteins Casp3 Tjp1 Tjp2 Cdh1 Pkp1 Dsg1a Dsg3 Dsp Dsg2 PTK6 REGULATES PROTEINS INVOLVED IN RNA PROCESSING%REACTOME DATABASE ID RELEASE 59%8849468 PTK6 Regulates Proteins Involved in RNA Processing Khdrbs2 Khdrbs1 Khdrbs3 Ptk6 Sfpq SOS-MEDIATED SIGNALLING%REACTOME%R-HSA-112412.2 SOS-mediated signalling Akap9 Ppp2r1a Csf2 Jak1 Frs2 Nras Frs3 Rasgrf1 Psmf1 Raf1 Psme4 Il5ra Fgf1 Il17rd Fgf2 Csk Cnksr1 Cnksr2 Erbb2 Fgf9 Ptk2 Fgf7 Psme3 Fgf6 Fgf4 Fgf3 Ppp5c Ranbp9 Ppp2cb Shc1 Lamtor2 Nrg2 Ppp2ca Shc3 Nrg1 Shc2 Psma7 Artn Nrtn Brap Psmb5 Psmb4 Ubc Nrg3 Psmb7 Nrg4 Psmb6 Psmb2 Psmb3 Psmb1 Mapk3 Mapk1 Ksr1 Ptpra Dusp16 Dusp10 Map3k11 Paqr3 Psme2 Psme1 Ncam1 Sos1 Braf Psmb10 Apbb1ip Psmb11 Csf2rb2 Rapgef2 Csf2ra Actn2 Nf1 Pdgfrb Pdgfra Kbtbd7 Il2rg Arrb2 Egfr Arrb1 Ret Vwf Sptan1 Pspn Map2k1 Rbx1 Fgg Map2k2 Cul3 Psmd12 Pdgfb Psmd11 Rasgef1a Psmd14 Rasa3 Rasa4 Psmd13 Psmd10 Il2 Rasa2 Rasa1 Nefl Spred3 Kit Spred2 Grin2a Spred1 Spta1 Il5 Ppp2r1b Sptbn4 Ywhab Kras Gdnf Shfm1 Irs2 Syngap1 Hbegf Irs1 Il3ra Btc Il2ra Il2rb Angpt1 Psmc6 Egf Fgf23 Psmc5 Fgf22 Mark3 Psmc2 Fgf20 Psmd2 Dab2ip Tek Psmb9 Psmb8 Araf Hras Grin1 Ppp2r5e Dlg4 Ppp2r5c Ppp2r5d Ppp2r5a Psmc1 Psmc4 Psmc3 Sptbn2 Itgb3 Sptbn1 Fyn Phb Grin2c Rasgrp4 Rasgrp3 Pebp1 Ppp2r5b Rasgrp1 Tln1 Fga Fgb Grin2d Grin2b Sptb Hgf Gfra2 Gfra3 Gfra4 Ereg Jak2 Pea15a Itga2b Rap1a Jak3 Wdr83 Camk2d Rap1b Camk2a Fgfr4 Camk2b Psma5 Rasal3 Rasal2 Psma4 Psma3 Psma6 Vcl Camk2g Psma2 Psma1 Gfra1 Psmd9 Dusp7 Iqgap1 Fgf16 Dusp6 Dusp9 Fgf15 Dusp8 Klb Fgf18 Psmd1 Met Fn1 Rasal1 Dusp1 Psmd3 Psmd4 Psmd6 Psmd5 Dusp2 Psmd7 Dusp5 Psmd8 Fgf10 Dusp4 ABACAVIR TRANSPORT AND METABOLISM%REACTOME DATABASE ID RELEASE 59%2161522 Abacavir transport and metabolism Guk1 Abcb1a Pck1 Adal Slc22a2 Nt5c2 Slc22a1 Slc22a3 Abcg2 ATTACHMENT OF GPI ANCHOR TO UPAR%REACTOME DATABASE ID RELEASE 59%162791 Attachment of GPI anchor to uPAR Pigk Pigs Pgap1 Pigu Gpaa1 Plaur Pigt VIRAL MRNA TRANSLATION%REACTOME DATABASE ID RELEASE 59%192823 Viral mRNA Translation Rpl39 Rplp1 Rpl7 Rps21 Rps27 Rplp2 Rps25 Rpl4 Rps26 Rps27l Rpl18a Rpl34 Rpl32 Rpl26 Rpl24 Rps9 Rps7 Dnajc3 Rps5 Rpl22 Rpl10l Rpl23 Rpl39l Rpl13a Rpl22l1 Rps15a Rpl11 Rpl17 Rps3 Rpl19 Rpl18 Rps16 Rps14 Grsf1 Rps19 Rps18 Rps11 Rps10 Rpsa Rpl37 Rps4x GLYCOPROTEIN HORMONES%REACTOME DATABASE ID RELEASE 59%209822 Glycoprotein hormones Lhb Inhbc Inhbe Fshb Inha Inhba Inhbb Tshb Cga NS1 MEDIATED EFFECTS ON HOST PATHWAYS%REACTOME%R-HSA-168276.3 NS1 Mediated Effects on Host Pathways Nup85 Nup160 Nup37 Nup50 Nup43 Tpr Isg15 Nup133 Cpsf4 Ndc1 Nup214 Aaas Nup210 Nup188 Nup54 Nup35 Nupl2 Nup62 Nup205 Nup155 Nup88 Pom121 Rae1 Pabpn1 Nup93 Nup153 Kpnb1 Kpna1 Ranbp2 Nup107 Kpna3 Kpna4 Kpna7 Eif2ak2 SCAVENGING BY CLASS B RECEPTORS%REACTOME%R-HSA-3000471.2 Scavenging by Class B Receptors Cd36 Saa3 Apoa1 Apob TNF RECEPTOR SUPERFAMILY (TNFSF) MEMBERS MEDIATING NON-CANONICAL NF-KB PATHWAY%REACTOME%R-HSA-5676594.1 TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway Lta Ltb Birc3 Birc2 Tnfsf14 Ltbr Tnfsf12 Map3k14 Tnfrsf12a Traf3 Tnfsf13b Tnfrsf11a Traf2 Tnfrsf13c Tnfsf11 Cd40lg AROMATIC AMINES CAN BE N-HYDROXYLATED OR N-DEALKYLATED BY CYP1A2%REACTOME DATABASE ID RELEASE 59%211957 Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 Cyp1a2 ASSEMBLY OF VIRAL COMPONENTS AT THE BUDDING SITE%REACTOME DATABASE ID RELEASE 59%168316 Assembly of Viral Components at the Budding Site Canx Calr NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME DATABASE ID RELEASE 59%427413 NoRC negatively regulates rRNA expression Mbd2 Smarca5 Hist2h3c1 Sap30l Polr1a Znrd1 Polr1e Hdac1 H2afj H2afb2 Polr2f Polr2e Polr2h Hdac2 Tbp Mnat1 Ubtf Sap30 Polr1b Suds3 Polr2k Arid4b Hist2h2be Hist3h2ba Sap30bp Polr1d Sap130 Polr1c Hist2h2ac Ttf1 Gtf2h1 H3f3b H3f3a Gtf2h2 Hist1h2bg Gtf2h5 Hist1h2bh Gm10094 Gtf2h4 Dnmt3b Cd3eap Hist1h2bp Hist1h2bm Hist1h2bj Hist1h2bb Gtf2h3 Ercc3 Sin3b Baz2a H2afz Taf1d H2afx Taf1c Taf1b Taf1a Ercc2 Dnmt1 Hist2h2aa1 Hist1h3d Ccnh Hist1h2ak Hist1h2ag Sin3a Cdk7 Hist1h2ah RNA POLYMERASE I TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 59%73863 RNA Polymerase I Transcription Termination Gtf2h5 Gtf2h4 Cd3eap Gtf2h3 Ercc3 Polr1a Polr1e Znrd1 Taf1d Taf1c Taf1b Taf1a Ercc2 Polr2f Polr2e Polr2h Tbp Mnat1 Ubtf Polr1b Polr2k Ptrf Ccnh Cdk7 Polr1d Ttf1 Polr1c Gtf2h1 Gtf2h2 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF SATURATED FATTY ACIDS%REACTOME%R-HSA-77286.2 mitochondrial fatty acid beta-oxidation of saturated fatty acids Echs1 Acadl Acsm3 Hadhb Acadm Hadha Hadh Acadvl Acads CONSTITUTIVE SIGNALING BY AKT1 E17K IN CANCER%REACTOME DATABASE ID RELEASE 59%5674400 Constitutive Signaling by AKT1 E17K in Cancer Creb1 Casp9 Chuk Cdkn1a Tsc2 Akt2 Gsk3a Akt3 Gsk3b Mlst8 Rictor Mapkap1 Pdpk1 Mdm2 Bad Cdkn1b Rps6kb2 Mtor Akt1s1 Nr4a1 Foxo3 Prr5 Akt1 Foxo1 GLOBAL GENOME NUCLEOTIDE EXCISION REPAIR (GG-NER)%REACTOME%R-HSA-5696399.1 Global Genome Nucleotide Excision Repair (GG-NER) Lig3 Actb Pcna Ddb1 Pias3 Polk Rfc5 Ube2v2 Rfc3 Cetn2 Rfc2 Rfc4 Rnf111 Yy1 Rfc1 Ddb2 Mnat1 Pole Sumo3 Pold1 Pold2 Pold3 Pold4 Chd1l Xpa Pole2 Rpa2 Ercc5 Cul4a Rpa1 Pias1 Rad23a Usp45 Rad23b Xpc Rpa3 Ube2i Lig1 Ercc4 Gtf2h1 Pole4 Ercc1 Cul4b Gtf2h2 Pole3 Gtf2h5 Gtf2h4 Rbx1 Ino80 Ruvbl1 Gtf2h3 Ercc3 Parp1 Ubc Ercc2 Ino80c Ino80b Ino80e Ino80d Nfrkb Cops7b Cops7a Parp2 Xrcc1 Ube2n Cops8 Cops6 Cops2 Ccnh Cops4 Cops5 Cops3 Cdk7 Actl6a Tfpt Actr8 Actr5 SALM PROTEIN INTERACTIONS AT THE SYNAPSES%REACTOME DATABASE ID RELEASE 59%8849932 SALM protein interactions at the synapses Grin2c Dlg1 Lrfn2 Lrfn3 Gria3 Gria4 Dlg3 Grin1 Ptprf Dlg4 Flot2 Flot1 Gria1 Lrfn4 Rtn3 Grin2d Grin2b Ptprs Grin2a ADRENOCEPTORS%REACTOME%R-HSA-390696.1 Adrenoceptors Adra1a Adra2a Adra1b Adra2c Adra2b Adra1d Adrb2 Adrb1 Adrb3 NUCLEOTIDE METABOLISM%REACTOME DATABASE ID RELEASE 59%15869 Nucleotide metabolism Tk1 Hdhd1a Uck1 Uck2 Ampd1 Rrm2b Hprt Atic Pnp Cda Cat Paics Gpx1 Dck Rrm2 Adk Tyms Adssl1 Dctd Adsl Tk2 Gart Gda Xdh Rrm1 Tymp Upp2 Upp1 Agxt2 Nt5m Guk1 Adal Nt5c2 Taf9 Nt5c1a Nt5e Nt5c Upb1 Dpyd Txnrd1 Dpys Dtymk Ctps Entpd2 Txn1 Entpd1 Entpd4 Entpd3 Entpd6 Adprm Cad Glrx Nme1 Adss Nme4 Gmpr Aprt Ppat Ak8 Ada Pfas Ampd2 Ak7 Ampd3 Ak5 Entpd8 Entpd5 Entpd7 Dguok Impdh1 Gmpr2 Lhpp Gmps Nudt5 Gm21685 Ak6 Umps Ctps2 Dctpp1 Ak1 Ak2 Dhodh Nudt15 Nudt13 Itpa Nudt16 Cmpk1 SEROTONIN AND MELATONIN BIOSYNTHESIS%REACTOME%R-HSA-209931.1 Serotonin and melatonin biosynthesis Tph2 Ddc Tph1 Aanat HS-GAG DEGRADATION%REACTOME DATABASE ID RELEASE 59%2024096 HS-GAG degradation Agrn Sdc3 Sdc4 Gpc6 Sdc2 Gpc3 Sdc1 Gpc5 Glb1 Gpc2 Gpc4 Ids Hpse2 Idua Naglu Gusb Hpse Sgsh Hspg2 Gpc1 THE FATTY ACID CYCLING MODEL%REACTOME DATABASE ID RELEASE 59%167826 The fatty acid cycling model Slc25a27 Slc25a14 Ucp1 Ucp3 Ucp2 MGMT-MEDIATED DNA DAMAGE REVERSAL%REACTOME DATABASE ID RELEASE 59%5657655 MGMT-mediated DNA damage reversal Mgmt MHC CLASS II ANTIGEN PRESENTATION%REACTOME DATABASE ID RELEASE 59%2132295 MHC class II antigen presentation Sar1b Kif15 Canx Cd74 Sec23a Dynll2 Arf1 Osbpl1a Kif11 Dync1i1 Sptbn2 Ifi30 Lag3 Klc3 Dynll1 Klc2 Sec24a Klc4 Sec24b Ctse Sec13 Ctsf Ctso Racgap1 Sec24d Actr1a Sec24c H2-DMb2 Dync1i2 Cenpe Kif2c Dctn2 Lgmn Ap2m1 Kif2b Dctn3 Kif18a Sec31a Kif3c Kif3b Kif3a Kif2a Ap2a1 Dync1h1 Ctsh Ap2a2 Rilp Sh3gl2 Ctsa H2-Oa Dnm2 H2-Ob Klc1 Ap2s1 Dnm1 Dctn5 Dctn6 Kif26a Dctn1 Ctss H2-DMa Kif5a Kif5b Dctn4 Rab7 Ctsb Ctsk Dync1li2 Ctsl Clta Dync1li1 Ap2b1 Ctsd H2-Aa Ap1s2 Kif4 Ap1b1 Ap1s1 Cltc H2-Eb1 Kif20a Ap1g1 Actr1b Dnm3 Kifap3 Ap1s3 Kif22 Ctsc Ap1m2 Kif23 Ap1m1 PHOSPHORYLATION OF EMI1%REACTOME DATABASE ID RELEASE 59%176417 Phosphorylation of Emi1 Cdk1 Fbxo5 Cdc20 Plk1 Fzr1 BASIGIN INTERACTIONS%REACTOME DATABASE ID RELEASE 59%210991 Basigin interactions Itga6 Slc7a10 Itgb1 Slc7a11 Atp1b2 Atp1b3 Atp1b1 Ppil2 Spn Ppia Slc7a6 Slc3a2 Mmp1a Slc7a9 Slc7a8 Itga3 Slc7a7 Mag L1cam Cav1 Slc7a5 Slc16a3 Slc16a1 Bsg Slc16a8 CHL1 INTERACTIONS%REACTOME DATABASE ID RELEASE 59%447041 CHL1 interactions Chl1 Itgb1 Nrp1 Hspa8 Itga1 Itga2 Ank1 Itga10 Cntn6 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA%REACTOME%R-HSA-112297.2 Post-Elongation Processing of Intronless pre-mRNA Nudt21 Cstf2t Pabpn1 Fip1l1 Cstf3 Sympk Cstf2 Zfp473 Cpsf3 Cpsf2 Cpsf4 Cpsf7 Lsm11 Cpsf1 Cstf1 Clp1 Papola Wdr33 Lsm10 Ncbp1 Snrpb Ncbp2 Snrpd3 Slbp HHAT G278V ABROGATES PALMITOYLATION OF HH-NP%REACTOME DATABASE ID RELEASE 59%5658034 HHAT G278V abrogates palmitoylation of Hh-Np Ihh Shh Dhh TERMINATION OF TRANSLESION DNA SYNTHESIS%REACTOME DATABASE ID RELEASE 59%5656169 Termination of translesion DNA synthesis Poli Usp43 2810417H13Rik Rev1 Polh Pcna Isg15 Ube2l6 Trim25 Polk Rfc5 Ubc Rfc3 Rfc2 Rfc4 Rfc1 Pole Pold1 Pold2 Pold3 Pold4 Uba7 Pole2 Rpa2 Usp10 Rpa1 Rpa3 Pole4 Pole3 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS%REACTOME DATABASE ID RELEASE 59%176187 Activation of ATR in response to replication stress Chek1 Cdc25c Clspn Trex1 Rfc5 Mcm6 Rad9a Rfc3 Rad1 Cdc6 Cdk2 Mcm3 Rad9b Mcm2 Mcm5 Hus1 Mcm4 Rfc2 Cdc7 Cdc25a Dbf4 Mcm10 Rfc4 Orc4 Orc5 Mcm8 Mcm7 Cdc45 Atrip Orc2 Orc3 Orc6 Orc1 Rpa2 Rpa1 Rpa3 Rad17 METAL ION SLC TRANSPORTERS%REACTOME%R-HSA-425410.1 Metal ion SLC transporters Slc39a14 Slc41a2 Slc41a1 Heph Cp Slc40a1 Slc30a1 Slc39a1 Slc39a10 Slc30a2 Slc30a3 Slc39a5 Slc39a4 Slc39a3 Slc39a2 Slc39a8 Slc39a6 Slc39a7 Slc30a5 Slc11a1 Slc30a8 Slc31a1 Slc30a6 Slc30a7 Slc11a2 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME DATABASE ID RELEASE 59%975144 IRAK1 recruits IKK complex upon TLR7 8 or 9 stimulation Peli1 Chuk Irak1 Peli3 Traf6 Ikbkb Peli2 Ube2v1 Ube2n Ikbkg REGULATION OF TP53 EXPRESSION%REACTOME%R-HSA-6804754.1 Regulation of TP53 Expression Trp53 Prdm1 TRANSLESION SYNTHESIS BY Y FAMILY DNA POLYMERASES BYPASSES LESIONS ON DNA TEMPLATE%REACTOME DATABASE ID RELEASE 59%110313 Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template Poli Usp43 2810417H13Rik Ufd1l Vcp Rchy1 Rev1 Polh Pcna Isg15 Ube2l6 Polk Trim25 Rfc5 Ubc Rfc3 Rfc2 Rfc4 Rfc1 Pole Pold1 Pold2 Pold3 Pold4 Uba7 Mad2l2 Pole2 Rpa2 Usp10 Rpa1 Nploc4 Sprtn Rpa3 Pole4 Rev3l Pole3 RNA POLYMERASE II TRANSCRIBES SNRNA GENES%REACTOME%R-HSA-6807505.2 RNA polymerase II transcribes snRNA genes Gtf2a1 Gtf2a2 Cdk9 Gtf2b Asun Pou2f1 Sp1 Rprd2 Zfp143 Taf5 Taf6 Pou2f2 Polr2f Polr2i Gtf2e1 Ints6 Polr2e Polr2j Polr2h Ints7 Gtf2e2 Tbp Ell Polr2c Polr2d Rpap2 Ints4 Polr2b Ints5 Ice1 Phax Ints1 Ints3 Ints8 Taf9 Polr2g Ints9 Polr2k Srrt Ccnt1 Cpsf3l Ints2 Polr2a Gtf2f1 Ccnt2 Ncbp1 Ncbp2 Gtf2f2 Ell3 Taf13 Taf11 Ell2 Ints10 Ints12 Taf8 Ice2 Zc3h8 Nabp1 Nabp2 Rprd1a Rprd1b Ak6 Snapc2 Snapc1 Vwa9 Snapc4 Ccnk Snapc5 Cdk7 Snapc3 GABA A RECEPTOR ACTIVATION%REACTOME%R-HSA-977441.1 GABA A receptor activation Gabrb2 Gabrq Gabra2 Gabra5 Gabra1 Gabra6 Arhgef9 Gabra3 Gabra4 Gabrg2 Gabrb3 Gabrg3 Gabrb1 GLYCOSAMINOGLYCAN METABOLISM%REACTOME DATABASE ID RELEASE 59%1630316 Glycosaminoglycan metabolism Agrn Hyal2 Lum Ndst2 Naglu B4galt7 Dse Hyal1 Hyal3 Arsb Chst3 Hs3st2 Chsy1 Chpf Bgn Dcn Chsy3 Lyve1 Bcan Chst15 B3gat3 B3gat2 B3gat1 Hpse2 Hs3st5 Hs3st6 Hs3st4 Cspg4 Hs3st1 Cspg5 Hs6st1 St3gal4 Chst2 Hs6st3 Chst5 Hs6st2 Hs2st1 Chst1 Chst13 Csgalnact1 Glce Csgalnact2 Ncan Sgsh Xylt2 Chst12 Vcan Chst7 Xylt1 Chst11 Dsel Chst14 Ext2 Ext1 Chp1 Ust Glb1 Ndst3 Ndst1 Ndst4 Ids B3galt6 Idua Hs3st3a1 B3gnt3 B3gnt2 B3gnt7 B3gnt4 Hs3st3b1 Hexb Gusb Hpse B4galt3 Slc35b2 B4galt1 Slc26a1 B4galt5 Omd B4galt4 Prelp B4galt6 Kera Ogn B4galt2 Hmmr Slc26a2 Slc35b3 Papss2 Papss1 Hexa B4gat1 Slc9a1 Stab2 Sdc3 Sdc4 Gpc6 Sdc2 Gpc3 Sdc1 Gpc5 Gpc2 Gpc4 Fmod St3gal1 St3gal2 Has3 Abcc5 Has1 Cemip Slc35d2 Has2 Cd44 Hspg2 Gns St3gal6 Gpc1 INLA-MEDIATED ENTRY OF LISTERIA MONOCYTOGENES INTO HOST CELLS%REACTOME DATABASE ID RELEASE 59%8876493 InlA-mediated entry of Listeria monocytogenes into host cells Ctnnd1 Ubc Cdh1 Cbll1 Src Ctnnb1 PAUSING AND RECOVERY OF HIV ELONGATION%REACTOME DATABASE ID RELEASE 59%167290 Pausing and recovery of HIV elongation Cdk9 Polr2i Polr2f Polr2j Polr2e Nelfa Polr2h Nelfb Ell Polr2c Polr2d Supt4a Polr2b Tcea1 Tceb1 Tceb3 Supt16 Polr2k Polr2g Ccnt1 Ctdp1 Ssrp1 Ccnk Polr2a Nelfe Supt5 Nelfcd Gtf2f1 Ccnt2 Gtf2f2 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE%REACTOME%R-HSA-352230.2 Amino acid transport across the plasma membrane Slc7a10 Slc1a5 Slc1a4 Slc38a1 Slc7a11 Slc38a2 Slc38a5 Slc38a4 Slc38a3 Slc7a6 Slc3a2 Slc43a1 Slc7a1 Slc7a3 Slc7a9 Slc3a1 Slc43a2 Slc7a8 Slc6a6 Slc7a7 Slc6a20a Slc6a18 Slc6a19 Slc7a5 Slc6a15 Slc6a14 Slc6a12 Slc36a1 Slc36a2 METHYLATION%REACTOME%R-HSA-156581.4 Methylation Tpmt Mat2a Ahcy Trmt112 Cyp1a2 N6amt1 Mat2b Mtrr Gsto1 Nnmt As3mt Mat1a Mtr Comt INTERLEUKIN-2 SIGNALING%REACTOME%R-HSA-451927.2 Interleukin-2 signaling Akap9 Ppp2r1a Csf2 Ptk2b Jak1 Frs2 Nras Frs3 Rasgrf1 Psmf1 Raf1 Psme4 Il5ra Fgf1 Il17rd Fgf2 Cnksr1 Csk Cnksr2 Erbb2 Fgf9 Ptk2 Fgf7 Psme3 Fgf6 Fgf4 Fgf3 Ppp5c Ranbp9 Ppp2cb Shc1 Lamtor2 Nrg2 Ppp2ca Shc3 Nrg1 Shc2 Psma7 Artn Nrtn Brap Gab2 Psmb5 Psmb4 Ubc Nrg3 Psmb7 Nrg4 Psmb6 Psmb2 Psmb3 Psmb1 Mapk3 Mapk1 Ksr1 Ptpra Dusp16 Dusp10 Map3k11 Paqr3 Psme2 Psme1 Ncam1 Sos1 Braf Psmb10 Apbb1ip Psmb11 Csf2rb2 Rapgef2 Csf2ra Actn2 Nf1 Pdgfrb Stat5b Pdgfra Stat5a Kbtbd7 Il2rg Arrb2 Egfr Arrb1 Ret Vwf Sptan1 Pspn Map2k1 Rbx1 Fgg Map2k2 Cul3 Psmd12 Pdgfb Psmd11 Rasgef1a Psmd14 Rasa3 Rasa4 Psmd13 Inppl1 Psmd10 Il2 Rasa2 Rasa1 Nefl Spred3 Kit Spred2 Grin2a Spred1 Spta1 Il5 Sptbn4 Ppp2r1b Ywhab Kras Gdnf Shfm1 Irs2 Syngap1 Lck Hbegf Ptpn6 Irs1 Il3ra Btc Il2ra Il2rb Angpt1 Psmc6 Egf Fgf23 Psmc5 Fgf22 Mark3 Psmc2 Fgf20 Psmd2 Dab2ip Tek Psmb9 Psmb8 Araf Hras Grin1 Ppp2r5e Dlg4 Ppp2r5c Ppp2r5d Ppp2r5a Psmc1 Psmc4 Psmc3 Pik3cb Sptbn2 Pik3cd Sptbn1 Itgb3 Fyn Phb Grin2c Rasgrp4 Rasgrp3 Inpp5d Pebp1 Ppp2r5b Rasgrp1 Syk Tln1 Pik3ca Fga Fgb Grin2d Grin2b Sptb Hgf Gfra2 Gfra3 Gfra4 Ereg Jak2 Pea15a Itga2b Rap1a Jak3 Wdr83 Camk2d Rap1b Camk2a Fgfr4 Camk2b Psma5 Rasal3 Rasal2 Psma4 Psma3 Psma6 Vcl Camk2g Psma2 Psma1 Gfra1 Psmd9 Dusp7 Iqgap1 Fgf16 Dusp6 Dusp9 Fgf15 Dusp8 Klb Fgf18 Psmd1 Met Fn1 Rasal1 Dusp1 Psmd3 Psmd4 Psmd6 Psmd5 Dusp2 Pik3r3 Psmd7 Pik3r1 Dusp5 Psmd8 Fgf10 Pik3r2 Dusp4 ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS%REACTOME%R-HSA-181431.2 Acetylcholine Binding And Downstream Events Chrnb2 Chrnb4 Chrnb3 Chrnd Chrng Chrna9 Chrne Chrna4 Chrna5 Chrna3 Chrna1 Chrna6 Chrna7 Chrna2 TFAP2A ACTS AS A TRANSCRIPTIONAL REPRESSOR DURING RETINOIC ACID INDUCED CELL DIFFERENTIATION%REACTOME DATABASE ID RELEASE 59%8869496 TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation Hspd1 Tfap2a Mybl2 Nop2 Npm1 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME%R-HSA-354194.1 GRB2:SOS provides linkage to MAPK signaling for Integrins Fgg Itga2b Rap1a Rap1b Fn1 Tln1 Sos1 Apbb1ip Fga Fgb Vwf Ptk2 Itgb3 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX%REACTOME%R-HSA-937072.1 TRAF6 mediated induction of TAK1 complex Map3k7 Ticam2 Irak2 Ticam1 Tab1 Traf6 Tab2 Tab3 Tlr4 Tlr3 Ly96 Cd14 Ubc APC TRUNCATION MUTANTS ARE NOT K63 POLYUBIQUITINATED%REACTOME DATABASE ID RELEASE 59%5467333 APC truncation mutants are not K63 polyubiquitinated Apc REGULATION OF APOPTOSIS%REACTOME%R-HSA-169911.2 Regulation of Apoptosis Psmc6 Psmc5 Psmc2 Psmd2 Psmb9 Psmb8 Psmf1 Psme4 Psmc1 Psmc4 Opa1 Psmc3 Psme3 Oma1 Psmd12 Psmd11 Psma7 Psmd14 Psma5 Psmb5 Psmb4 Psmd13 Ubc Psmd10 Psma4 Psma3 Psmb7 Arhgap10 Psma6 Psmb6 Psmb2 Psmb3 Psma2 Psmb1 Psma1 Psmd9 Psmd1 Psme2 Shfm1 Pak2 Psme1 Psmd3 Psmd4 Psmb10 Psmd6 Psmd5 Psmd7 Psmb11 Psmd8 MAPK6 MAPK4 SIGNALING%REACTOME DATABASE ID RELEASE 59%5687128 MAPK6 MAPK4 signaling Psmc6 Cdc42ep3 Cdc42ep5 Etv4 Psmc5 Igf2bp1 Psmc2 Psmd2 Sept7 Prkacb Psmb9 Xpo1 Mapkapk5 Psmf1 Psmb8 Cdc42ep2 Psme4 Cdk1 Cdc14b Mapk4 Mapk6 Psmc1 Psmc4 Psmc3 Foxo3 Psme3 Foxo1 Dnajb1 Rac1 Jun Pak1 Ccnd3 Prkaca Ncoa3 Hspb1 Psmd12 Psma7 Psmd11 Psmd14 Psma5 Psmb5 Psmb4 Ubc Psmd13 Psmd10 Psma4 Myc Psmb7 Psma3 Rag2 Psma6 Rag1 Psmb6 Psmb2 Psmb3 Psmb1 Psma2 Psma1 Psmd9 Ago2 Ago1 Tnrc6c Cdc14a Kalrn Tnrc6b Psmd1 Shfm1 Psme2 Pak3 Tnrc6a Pak2 Ago4 Psme1 Ago3 Psmd3 Psmd4 Psmb10 Psmd6 Psmd5 Psmd7 Psmb11 Psmd8 Mov10 INTERLEUKIN-19, 20, 22, 24%REACTOME%R-HSA-8854691.1 Interleukin-19, 20, 22, 24 Il19 Il22ra1 Il20rb Il20ra Iltifb Il22ra2 Il10rb Il20 Il24 RHO GTPASES ACTIVATE NADPH OXIDASES%REACTOME%R-HSA-5668599.4 RHO GTPases Activate NADPH Oxidases Pik3c3 Cybb Rac1 Cyba Pik3r4 Ncf4 Noxo1 Rac2 Ncf2 Noxa1 Ncf1 Nox3 Nox1 RESPONSE OF MTB TO PHAGOCYTOSIS%REACTOME%R-HSA-1222499.1 Response of Mtb to phagocytosis Ltf IL-6-TYPE CYTOKINE RECEPTOR LIGAND INTERACTIONS%REACTOME%R-HSA-6788467.1 IL-6-type cytokine receptor ligand interactions Ebi3 Jak1 Osm Jak2 Lifr Il27 Il12a Il11 Cntf Il6st Il27ra Crlf1 Ctf1 Tyk2 Clcf1 Osmr Cntfr Il12rb2 Il11ra2 Gm13305 Lif FORMATION OF RNA POL II ELONGATION COMPLEX%REACTOME%R-HSA-112382.2 Formation of RNA Pol II elongation complex Cdk9 Supt6 Polr2f Polr2i Polr2e Polr2j Polr2h Nelfa Nelfb Ell Mnat1 Polr2c Rtf1 Polr2d Supt4a Polr2b Mllt1 Mllt3 Aff4 Polr2g Polr2k Ctdp1 Ccnt1 Ssrp1 Wdr61 Polr2a Nelfe Supt5 Nelfcd Gtf2h1 Gtf2f1 Ncbp1 Ccnt2 Ncbp2 Gtf2h2 Gtf2f2 Gtf2h5 Paf1 Gtf2h4 Eaf1 Gtf2h3 Ercc3 Ctr9 Cdc73 Ercc2 Tcea1 Tceb1 Iws1 Tceb3 Supt16 Ccnh Ccnk Leo1 Cdk7 RECYCLING PATHWAY OF L1%REACTOME DATABASE ID RELEASE 59%437239 Recycling pathway of L1 Ap2m1 Ap2a1 Ap2a2 Msn Sh3gl2 Dnm2 Rps6ka5 Mapk1 Ap2s1 Dnm1 Rps6ka6 Rps6ka4 Rps6ka3 Rps6ka2 Rps6ka1 L1cam Clta Ap2b1 Ezr Kif4 Cltc Numb Dnm3 Dpysl2 Shtn1 Rdx NEGATIVE FEEDBACK REGULATION OF MAPK PATHWAY%REACTOME DATABASE ID RELEASE 59%5674499 Negative feedback regulation of MAPK pathway Braf Map2k1 Map2k2 Mapk3 Mapk1 Raf1 NICD TRAFFICS TO NUCLEUS%REACTOME DATABASE ID RELEASE 59%157052 NICD traffics to nucleus Crebbp Maml1 Notch4 Notch1 Mamld1 Maml3 Rbpj Kat2b Notch3 Maml2 Kat2a Notch2 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION%REACTOME DATABASE ID RELEASE 59%2151209 Activation of PPARGC1A (PGC-1alpha) by phosphorylation Prkag2 Prkag1 Mapk12 Prkag3 Mapk14 Prkaa2 Prkab2 Ppargc1a Prkab1 Mapk11 MOLECULES ASSOCIATED WITH ELASTIC FIBRES%REACTOME%R-HSA-2129379.1 Molecules associated with elastic fibres Ltbp2 Ltbp4 Mfap1b Itga8 Itgb1 Ltbp3 Gdf5 Tgfb3 Efemp2 Tgfb2 Ltbp1 Efemp1 Itgav Itgb3 Tgfb1 Itgb6 Itgb5 Vtn Bmp4 Bmp2 Mfap2 Mfap3 Mfap5 Bmp7 Bmp10 Mfap4 Itgb8 Fbln1 Fbln2 Fbln5 STIMULI-SENSING CHANNELS%REACTOME DATABASE ID RELEASE 59%2672351 Stimuli-sensing channels Slc9c1 Scnn1b Trpc6 Scnn1a Ano8 Ano7 Scnn1g Ano5 Ano4 Clcn5 Best3 Slc9b1 Best2 Clcn7 Clcn6 Slc9b2 Best1 Raf1 Clca4a Bsnd Ano6 Ostm1 Sgk3 Trpc1 Sgk2 Unc79 Stom Clcn1 Clcn2 Clcn3 Nedd4l Tsc22d3 Trpc3 Stoml3 Asic1 Asic4 Trpc7 Asic5 Nalcn Trpv1 Trpv3 Trpv2 Trpv4 Trpa1 Clca1 Trpm2 Trpc4 Trpm1 Trpm7 Mcoln3 Sgk1 Mcoln2 Trpc5 Trpm3 Trpm6 Trpm5 Trpm8 Fkbp1b Trpm4 Trpc4ap Ubc Ttyh3 Wwp1 Clca2 Mcoln1 Ryr3 Ryr1 Ryr2 Slc17a3 Trdn Tpcn2 Tpcn1 Ttyh2 Asph Wnk4 Wnk1 Wnk2 Wnk3 Ano1 Clcn4-2 Ano2 Ano10 Sri Clcnka Clcnkb Trpv6 Trpv5 TRNA AMINOACYLATION%REACTOME%R-HSA-379724.1 tRNA Aminoacylation Lars2 Cars2 Tars Ears2 Nars Fars2 Tars2 Nars2 Dars2 Aars2 Iars2 Wars Ppa1 Ppa2 Rars2 Farsa Dars Rars Eef1e1 Lars Farsb Aimp1 Sars2 Iars Sars Gars Mars Aimp2 Eprs Hars2 Yars2 Qars Kars Pars2 Aars Vars2 Hars Wars2 Mars2 Cars Yars Vars SHC-MEDIATED CASCADE:FGFR4%REACTOME%R-HSA-5654719.2 SHC-mediated cascade:FGFR4 Fgf23 Fgf16 Kras Fgf15 Fgf20 Klb Nras Fgf18 Fgfr4 Hras Sos1 Fgf1 Fgf2 Fgf9 Fgf6 Fgf4 REGULATED PROTEOLYSIS OF P75NTR%REACTOME DATABASE ID RELEASE 59%193692 Regulated proteolysis of p75NTR Nfkb1 Traf6 Psen2 Adam17 Ncstn Aph1b Ngfr Rela DEADENYLATION OF MRNA%REACTOME DATABASE ID RELEASE 59%429947 Deadenylation of mRNA Eif4a1 Eif4a2 Cnot4 Cnot7 Cnot6l Cnot6 Cnot1 Eif4a3 Cnot3 Parn Cnot11 Cnot2 Paip1 Eif4b Cnot10 Cnot8 Eif4e Pan3 Pabpc1 Pan2 Eif4g1 Rqcd1 Tnks1bp1 INWARDLY RECTIFYING K+ CHANNELS%REACTOME%R-HSA-1296065.1 Inwardly rectifying K+ channels Kcnj8 Gngt1 Abcc9 Gng7 Gng4 Kcnj10 Gngt2 Kcnj3 Gng10 Kcnj16 Kcnj15 Kcnj6 Kcnj5 Kcnj1 Kcnj9 Gabbr2 Gabbr1 Kcnj11 Kcnj2 Gng12 Abcc8 Kcnj12 Gnb2 Gnb1 Kcnj4 Gnb3 Gng8 Gng3 Gng2 Kcnj14 RHO GTPASES ACTIVATE PKNS%REACTOME DATABASE ID RELEASE 59%5625740 RHO GTPases activate PKNs Ar Ywhag Ywhae Kdm4c Hist2h3c1 Ppp1r12a Rhoa H2afj H2afb2 Rac1 Kdm1a Hist3h2ba Hist2h2be Hist2h2ac Rhob H3f3b H3f3a Rhoc Hist1h2bg Hist1h2bh Ywhaz Cdc25c Ywhah Sfn Hist1h2bp Hist1h2bm Ppp1r14a Hist1h2bj Hist1h2bb Myl6 Myh11 Ppp1cb H2afz H2afx Myh14 Pkn2 Myh10 Pkn1 Ywhab Pkn3 Hist2h2aa1 Hist1h3d Myl12b Myl12a Pdpk1 Hist1h2ak Hist1h2ag Ppp1r12b Myh9 Ncoa2 Hist1h2ah PI-3K CASCADE:FGFR3%REACTOME%R-HSA-5654710.2 PI-3K cascade:FGFR3 Fgf23 Fgf16 Fgf20 Frs2 Fgf18 Pik3ca Fgf1 Gab1 Fgf2 Fgf9 Pik3r1 Ptpn11 Fgf4 HSF1 ACTIVATION%REACTOME DATABASE ID RELEASE 59%3371511 HSF1 activation Hsf1 Rpa2 Hsbp1 Rpa1 Vcp Hsp90ab1 Rpa3 Hdac6 Ywhae Hsp90aa1 CD28 DEPENDENT VAV1 PATHWAY%REACTOME%R-HSA-389359.1 CD28 dependent Vav1 pathway Vav1 Fyn Lck Rac1 Pak1 Cd80 Pak3 Pak2 Cd86 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK%REACTOME%R-HSA-881907.1 Gastrin-CREB signalling pathway via PKC and MAPK Trio Rps6ka3 Rps6ka2 Rps6ka1 F2rl3 F2rl2 Gpr4 Oxt Kiss1r Csk F2rl1 Grpr Ptgfr Ntsr1 Mapk7 Ntsr2 Ghsr Uts2b Uts2r Casr Trh Gna11 F2r Gnaq Gna15 Edn1 F2 Edn3 Gna14 Edn2 Lpar5 P2ry10 Brs3 Lpar6 Prkcd Prkce Actn2 Nf1 Pdgfrb Pdgfra Kbtbd7 Prkca Dgkb Npff Il2rg Arrb2 Dgka Egfr Arrb1 Ret Adrbk1 Vwf Dgke Dgkg Htr2a Htr2b Htr2c Rasgrp2 Agtr1a Pspn Map2k1 Rbx1 Pmch Fgg Map2k2 Cul3 Psmd12 Pdgfb Qrfp Psmd11 Hcrtr1 Hcrtr2 Rasgef1a Psmd14 Rasa3 Rasa4 Psmd13 Psmd10 Il2 Rasa2 Rasa1 Nefl Spred3 Gpr17 Fpr2 Kit Spred2 Grin2a Spred1 Il5 P2ry1 Ppp2r1b Ywhab P2ry2 Kras Gdnf Shfm1 Itpr1 Irs2 Avp Syngap1 Gast Avpr1a Hbegf Npffr1 Irs1 Avpr1b Cck Il3ra Npffr2 Btc Il2ra Il2rb P2ry6 Itpr3 Rgs2 Angpt1 Rgs3 Itpr2 Gngt1 Psmc6 Grp Gng7 Egf Fgf23 Abhd12 Gng4 Psmc5 Tbxa2r Fgf22 Gcg Mark3 Gngt2 Psmc2 Fgf20 Psmd2 Dab2ip Nmb Gng10 Tek Gcgr Psmb9 Psmb8 Araf Hras Grin1 Nmu Ppp2r5e Chrm3 Dlg4 Chrm1 Ppp2r5c Trhr Nms Ppp2r5d Gprc6a Ppp2r5a Psmc1 Psmc4 Kiss1 Psmc3 Chrm5 Itgb3 Fyn Creb1 Phb Xcr1 Grin2c Rasgrp4 Rasgrp3 Pebp1 Ppp2r5b Rasgrp1 Tln1 Pik3ca Gng11 Opn4 Gng13 Gng12 Gnb2 Gnb1 Gnb3 Gnb5 Fga Gnb4 Fgb Grin2d Gng8 Grin2b Nmbr Gng3 Hgf Gng2 Nps Gfra2 Gfra3 Gfra4 Ereg Jak2 Pea15a Dgkq Itga2b Lpar3 Rap1a Jak3 Lpar4 Lpar1 Wdr83 Lpar2 Camk2d Dgkh Rap1b Camk2a Fgfr4 Dgki Camk2b Psma5 Rasal3 Rasal2 Ltb4r2 Psma4 Psma3 Psma6 Ltb4r1 Vcl Camk2g Psma2 Psma1 Gfra1 Psmd9 Dusp7 Gpr68 Iqgap1 Fgf16 Gpr65 Dusp6 Dusp9 Fgf15 Dusp8 Klb Fgf18 Kalrn Abhd6 Psmd1 Met Fn1 Rasal1 Dusp1 Psmd3 Psmd4 Psmd6 Psmd5 Dusp2 Pik3r3 Dgkz Mmp3 Psmd7 Pik3r1 Dusp5 Psmd8 Fgf10 Pik3r2 Dusp4 Trpc6 Ffar3 Akap9 Nts Ppp2r1a Arhgef25 Saa3 Ptger1 App Gpr132 Prok1 Csf2 Mchr1 Prok2 Trpc3 Ffar2 Ffar1 Trpc7 Daglb Jak1 Prokr1 Agt Prokr2 Dagla Anxa1 Ptafr Nmur1 Nmur2 Cckar Mgll Hrh1 Cckbr Rgs18 Rgs19 Frs2 Nras Frs3 Rasgrf1 Psmf1 Raf1 Psme4 Qrfpr Il5ra Fgf1 Il17rd Rgs21 Fgf2 Cnksr1 Cnksr2 Erbb2 Fgf9 Ptk2 Fgf7 Psme3 Fgf6 Fgf4 Fgf3 Ppp5c Ranbp9 Ppp2cb Shc1 Cysltr1 Lamtor2 Adra1a Adra1b Nrg2 Adra1d Ppp2ca Shc3 Grk5 Nrg1 Shc2 Psma7 Artn Plcb1 Nrtn Plcb2 Uts2 Brap Hcrt Npsr1 Psmb5 Psmb4 Ubc Nrg3 Grm1 Psmb7 Nrg4 Grm5 Psmb6 Psmb2 Psmb3 Tacr2 Psmb1 Tacr3 Mapk3 Bdkrb1 Tacr1 Mapk1 Cysltr2 Ksr1 Bdkrb2 Kng2 Ptpra Dusp16 Rgsl1 Dusp10 Map3k11 Gnrh1 Paqr3 Psme2 Psme1 Ncam1 Sos1 Braf Plcb4 Plcb3 Psmb10 Apbb1ip Ppan Psmb11 Csf2rb2 Rapgef2 Csf2ra Oxtr Sptan1 Ednra Ednrb Prkcq Xcl1 Spta1 Prkch Sptbn4 Tac2 Tac1 Gnrhr Sptbn2 Sptbn1 Sptb NONSENSE-MEDIATED DECAY (NMD)%REACTOME DATABASE ID RELEASE 59%927802 Nonsense-Mediated Decay (NMD) Rpl39 Rplp1 Etf1 Rpl7 Rps21 Ppp2r1a Rps27 Rplp2 Rps25 Rpl4 Rps26 Rps27l Rpl18a Rpl34 Rpl32 Upf3a Upf1 Rpl26 Rpl24 Rps9 Rps7 Upf2 Rps5 Dcp1a Magoh Ppp2r2a Smg8 Smg1 Rpsa Smg6 Rpl37 Ncbp1 Smg7 Rps4x Smg9 Ncbp2 Smg5 Rbm8a Ppp2ca Casc3 Eif4a3 Upf3b Rnps1 Magohb Rpl22 Gspt1 Rpl10l Rpl23 Rpl39l Gspt2 Rpl13a Rpl22l1 Rps15a Rpl11 Rpl17 Rps3 Rpl19 Rpl18 Rps16 Rps14 Rps19 Rps18 Pabpc1 Rps11 Eif4g1 Rps10 ATTENUATION PHASE%REACTOME DATABASE ID RELEASE 59%3371568 Attenuation phase Dnajb1 Crebbp Hsf1 Hsbp1 Hsp90ab1 Ep300 Hspa8 Hspa1a Hspa2 Fkbp4 Hsp90aa1 Hspa1l DEFECTIVE CSF2RB CAUSES PULMONARY SURFACTANT METABOLISM DYSFUNCTION 5 (SMDP5)%REACTOME%R-HSA-5688849.1 Defective CSF2RB causes pulmonary surfactant metabolism dysfunction 5 (SMDP5) Sftpb Sftpc Csf2rb2 Sftpa1 Sftpd Csf2ra PHOSPHORYLATION OF PROTEINS INVOLVED IN THE G2 M TRANSITION BY CYCLIN A:CDC2 COMPLEXES%REACTOME%R-HSA-170145.2 Phosphorylation of proteins involved in the G2 M transition by Cyclin A:Cdc2 complexes Cdk1 Ccna1 Ccna2 TRANSMISSION ACROSS CHEMICAL SYNAPSES%REACTOME DATABASE ID RELEASE 59%112315 Transmission across Chemical Synapses Akap5 Grip1 Cacng8 Gria2 Grip2 Slc1a3 Cacng4 Slc1a2 Cacng3 Akap9 Cacng2 Dnajc5 Myo6 Slc1a7 Tspan7 Slc1a6 Slc38a2 Pick1 Gria3 Slc1a1 Gria4 Slc18a3 Prkcb Gad1 Arl6ip5 Naaa Gad2 Slc32a1 Cacna1b Cacfd1 Slc6a12 Slc6a11 Hspa8 Dlg1 Ap2a1 Dlg3 Slc22a2 Slc22a1 Rps6ka6 Rps6ka3 Slc5a7 Rps6ka2 Rps6ka1 Slc6a4 Gnat3 Slc6a1 Slc6a13 Arhgef9 Aldh2 Adcy7 Adcy6 Adcy5 Adcy4 Adcy3 Adcy2 Slc38a1 Adcy1 Rasgrf1 Adcy9 Adcy8 Raf1 Grik2 Abat Gnal Gabbr2 Gabbr1 Aldh5a1 Grik1 Plcb1 Plcb2 Snap25 Mapk1 Cacnb2 Cacnb3 Cacna2d2 Ppfia2 Ppfia1 Cacna2d3 Apba1 Braf Plcb3 Ppfia4 Syn3 Unc13b Syn1 Syn2 Cacnb4 Rab3a Syt1 Cacnb1 Slc18a2 Vamp2 Lin7c Cplx1 Lin7a Stx1a Actn2 Prkcg Prkca Gls2 Gria1 Nsf Chat Nefl Grin2a Cacna1e Cacna1a Glul Rras Mdm2 Grik3 Comt Slc6a3 Maoa Gngt1 Gng7 Gng4 Gngt2 Prkacb Gng10 Hras Grin1 Dlg4 Chrnb2 Gnai2 Creb1 Gnai1 Grin2c Kcnj5 Kcnj9 Gnai3 Chrnb4 Chrnb3 Camk4 Gls Gng11 Gng13 Gng12 Gnb2 Gnb1 Gnb3 Gnb5 Gnb4 Ache Grin2d Prkaca Gng8 Grin2b Gng3 Gng2 Gabrr2 Gabrr3 Gabrb2 Gabrr1 Camkk1 Kcnj10 Gabrq Kcnj3 Chrnd Gabra2 Kcnj16 Camk2d Kcnj15 Chrng Gabra5 Camk2a Gabra1 Gabra6 Camk2b Chrna9 Gabra3 Chrne Gabra4 Chrna4 Grik5 Cask Chrna5 Grik4 Chrna3 Camk2g Chrna1 Chrna6 Chrna7 Kcnj6 Gabrg2 Gabrg3 Chrna2 Lin7b Bche Kcnj2 Kcnj12 Pdpk1 Kcnj4 Ncald Gabrb3 Gabrb1 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 59%68689 CDC6 association with the ORC:origin complex Orc4 Orc5 Mcm8 E2f2 Cdc6 E2f1 E2f3 Orc2 Orc3 Orc6 Orc1 ACTIVATION OF C3 AND C5%REACTOME%R-HSA-174577.2 Activation of C3 and C5 C2 Cfb C3 Hc CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 59%68827 CDT1 association with the CDC6:ORC:origin complex Psmc6 Psmc5 Psmc2 Psmd2 Psmb9 Psmb8 Psmf1 Psme4 Cdc6 Psmc1 Psmc4 Psmc3 Psme3 Gmnn Orc4 Orc5 Mcm8 Cdt1 Orc2 Orc3 Orc6 Orc1 Psmd12 Psma7 Psmd11 Psmd14 Psma5 Psmb5 Psmb4 Psmd13 Ubc Psmd10 Psma4 Psma3 Psmb7 Psma6 Psmb6 Psmb2 Psmb3 Psmb1 Psma2 Psma1 Psmd9 Psmd1 Shfm1 Psme2 Psme1 Psmd3 Psmd4 Psmb10 Psmd6 Psmd5 Psmd7 Psmb11 Psmd8 VIF-MEDIATED DEGRADATION OF APOBEC3G%REACTOME%R-HSA-180585.1 Vif-mediated degradation of APOBEC3G Psmc6 Rbx1 Psmc5 Psmc2 Psmd2 Psmd12 Psma7 Psmd11 Psmb9 Psmf1 Psmb8 Cul5 Psma5 Psme4 Psmd14 Psmb5 Psmb4 Ubc Psmd13 Psma4 Psmd10 Psmb7 Psma3 Psma6 Psmb6 Psmb2 Psmc1 Psmb3 Psmc4 Psmb1 Psma2 Psmc3 Psma1 Psme3 Psmd9 Tceb1 Psmd1 Shfm1 Psme2 Psme1 Psmd3 Psmd4 Psmb10 Psmd6 Psmd5 Psmd7 Psmb11 Psmd8 LYSOSPHINGOLIPID AND LPA RECEPTORS%REACTOME DATABASE ID RELEASE 59%419408 Lysosphingolipid and LPA receptors S1pr5 Lpar5 S1pr2 Lpar3 Lppr3 S1pr3 Lppr2 Lpar1 S1pr1 Lpar2 S1pr4 Lppr1 Lppr5 Lppr4 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%R-HSA-111447.2 Activation of BAD and translocation to mitochondria Ywhab Ppp3cc Ywhaz Bcl2 Ywhah Sfn Akt2 Akt3 Ywhag Ywhae Ppp3r1 Bad Akt1 Bid MTORC1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 59%166208 mTORC1-mediated signalling Ywhab Rptor Lamtor2 Lamtor5 Rragd Rragb Rragc Rraga Eif4b Mlst8 Lamtor4 Eif4e Eef2k Eif4g1 Mtor Akt1s1 Eif4ebp1 Lamtor1 DNA REPLICATION PRE-INITIATION%REACTOME DATABASE ID RELEASE 59%69002 DNA Replication Pre-Initiation Psmc6 Psmc5 Psmc2 Psmd2 Psmb9 Psmf1 Psmb8 Psme4 Mcm6 Cdc6 Cdk2 Mcm3 Mcm2 Mcm5 Mcm4 E2f1 Psmc1 Psmc4 Psmc3 Psme3 Gmnn Orc4 Orc5 Mcm8 E2f2 Mcm7 Pole Cdt1 Cdc45 E2f3 Orc2 Orc3 Orc6 Orc1 Prim1 Pole2 Rpa2 Rpa1 Rpa3 Pola1 Pola2 Pole4 Prim2 Pole3 Psmd12 Psma7 Psmd11 Psmd14 Psma5 Psmb5 Psmb4 Ubc Psmd13 Psmd10 Psma4 Psmb7 Psma3 Psma6 Psmb6 Psmb2 Cdc7 Psmb3 Psmb1 Dbf4 Psma2 Mcm10 Psma1 Psmd9 Psmd1 Shfm1 Psme2 Psme1 Psmd3 Psmd4 Psmb10 Psmd6 Psmd5 Psmd7 Psmb11 Psmd8 PRE-NOTCH EXPRESSION AND PROCESSING%REACTOME DATABASE ID RELEASE 59%1912422 Pre-NOTCH Expression and Processing Mfng Rfng Maml3 Lfng St3gal4 Notch1 E2f1 Sel1l Poglut1 Tfdp2 Maml2 Pofut1 Tfdp1 Ccnd1 Maml1 Ago2 Notch4 Ago1 Atp2a1 Tnrc6c Trp53 Atp2a3 Jun Atp2a2 Tnrc6b E2f3 Tnrc6a Notch3 Ago4 Ago3 Notch2 Furin Crebbp B4galt1 Mamld1 Ep300 Rab6a Rbpj Kat2b Kat2a Mov10 St3gal6 VEGFR2 MEDIATED VASCULAR PERMEABILITY%REACTOME DATABASE ID RELEASE 59%5218920 VEGFR2 mediated vascular permeability Jup Ctnnd1 Akt2 Akt3 Cdh5 Nos3 Hsp90aa1 Mlst8 Vav1 Mapkap1 Mtor Akt1 Ctnna1 Rac1 Pak1 Them4 Vav2 Cav1 Pak3 Pak2 Rictor Pdpk1 Vav3 Prr5 Trib3 VPU MEDIATED DEGRADATION OF CD4%REACTOME%R-HSA-180534.1 Vpu mediated degradation of CD4 Psmc6 Psmc5 Psmc2 Psmd2 Psmd12 Psma7 Psmd11 Psmb9 Psmf1 Psmb8 Btrc Psma5 Psme4 Psmd14 Psmb5 Psmb4 Ubc Psmd13 Psma4 Psmd10 Skp1a Psmb7 Psma3 Psma6 Psmb6 Psmb2 Psmc1 Psmb3 Psmc4 Psmb1 Psma2 Psmc3 Psma1 Psme3 Psmd9 Psmd1 Shfm1 Psme2 Psme1 Psmd3 Psmd4 Psmb10 Psmd6 Psmd5 Cd4 Psmd7 Psmb11 Psmd8 MET ACTIVATES RAP1 AND RAC1%REACTOME%R-HSA-8875555.1 MET activates RAP1 and RAC1 Crkl Gab1 Rac1 Rap1a Crk Rapgef1 Met Rap1b Dock7 Hgf GALACTOSE CATABOLISM%REACTOME DATABASE ID RELEASE 59%70370 Galactose catabolism Pgm1 Gale Galk1 Pgm2 Galt MACROAUTOPHAGY%REACTOME DATABASE ID RELEASE 59%1632852 Macroautophagy Prkag2 Pik3c3 Prkag1 Prkag3 Becn1 Prkaa2 Tsc2 Pik3r4 Mlst8 Dynll2 Mtor Prkaa1 Rptor Dynll1 Wipi2 Rb1cc1 Atg101 Atg4b Atg4c Atg4a Atg4d Gabarapl1 Lamtor1 Atg9a Atg12 Atg9b Wdr45b Mtmr14 Chmp7 Lamtor2 Chmp6 Wdr45 Chmp3 Wipi1 Atg7 Lamtor5 Atg5 Rragd Gabarapl2 Atg16l1 Rragb Uvrag Rragc Ambra1 Rraga Tsc1 Atg10 Atg13 Chmp2a Chmp4c Atg3 Lamtor4 Mtmr3 Chmp4b Gabarap Map1lc3a Prkab1 Map1lc3b Prkab2 Ulk1 SPRY REGULATION OF FGF SIGNALING%REACTOME DATABASE ID RELEASE 59%1295596 Spry regulation of FGF signaling Ppp2cb Spry2 Braf Ubc Cbl Ppp2ca Ppp2r1a Mapk3 Ptpn11 Mapk1 Mknk1 DEFECTIVE B3GALTL CAUSES PETERS-PLUS SYNDROME (PPS)%REACTOME%R-HSA-5083635.1 Defective B3GALTL causes Peters-plus syndrome (PpS) Adamts12 Thsd4 Adamts19 Adamts10 Thsd1 Sspo Adamts20 Cfp Adamtsl3 Adamtsl4 Adamts4 Adamtsl1 Adamts13 Adamtsl2 Adamts1 Adamts14 Sbspon Adamts15 Sema5a Spon2 Thsd7a Adamts8 Adamts5 Adamtsl5 Spon1 Adamts3 Adamts18 Adamts6 Adamts16 Adamts7 Adamts2 Thbs1 Thsd7b Sema5b Thbs2 HISTIDINE CATABOLISM%REACTOME DATABASE ID RELEASE 59%70921 Histidine catabolism 2410127L17Rik Carns1 Hal Hnmt Hdc Amdhd1 Ftcd Uroc1 GP1B-IX-V ACTIVATION SIGNALLING%REACTOME DATABASE ID RELEASE 59%430116 GP1b-IX-V activation signalling Gp1bb Gp1ba Ywhaz Vwf Pik3r1 Gp5 Gp9 Raf1 Flna MEIOTIC SYNAPSIS%REACTOME DATABASE ID RELEASE 59%1221632 Meiotic synapsis Hist1h2bg Tinf2 Hist1h2bh Pot1a Terf1 Terf2 Hist1h2bp Lmnb1 Hist1h2bm Acd Hist1h2bj Hist1h2bb H2afz Terf2ip Smc3 H2afx H2afj H2afb2 Syne1 Syce3 Syce2 Hist2h2aa1 Syne2 Syce1 Hist1h3h Brca1 Stag2 Smc1b Hist1h2ak Stag1 Fkbp6 Hist2h2be Hist3h2ba Hist1h2ag Sun1 Hspa2 Sycp3 Smc1a Hist2h2ac Stag3 Rad21 Ube2i Rec8 Sycp2 Sycp1 Sun2 Hist1h2ah Tex12 PKA ACTIVATION IN GLUCAGON SIGNALLING%REACTOME%R-HSA-164378.2 PKA activation in glucagon signalling Adcy7 Adcy6 Adcy5 Adcy4 Adcy3 Adcy2 Prkar2a Adcy1 Prkacb Adcy9 Adcy8 Prkar2b Prkar1a Prkar1b Prkaca INNATE IMMUNE SYSTEM%REACTOME%R-HSA-168249.5 Innate Immune System Hspa1a Hspa8 Sdcbp Ap2a2 Itgav Dnm2 Rps6ka5 Dnm1 Rps6ka3 Rps6ka2 Rps6ka1 Vav2 Csnk2b Dnm3 Nfasc Slc2a5 Capn1 Csk Slc2a3 Pgm1 Dera P2rx1 P2rx7 Adam10 Gab2 Itch Kpnb1 H2-Q10 B2m Ap1m1 Trim21 Cda Nlrc4 Mb21d1 Trim32 Zbp1 Trim56 Map2k6 A1bg Mre11a Serpina3n Ctnnb1 S100a1 Cd180 S100a9 S100a8 Eea1 Ly86 Ptpn4 Itgb2 Bpi Itgam Ube2d1 Lck Cd4 Ptpn6 Casp1 Gyg Casp2 Ptpn11 Cd3g Alad Hmox2 Hsp90aa1 Prkar2b Cnpy3 Unc93b1 Pin1 Tubb4b Fabp5 Dynll1 Atf2 Crebbp Idh1 Apaf1 Fos Prkaca Psap Defb47 Atox1 Cfb Ahsg Lcn2 Camp Cfd Bpifb2 Cap1 C3 Bpifb1 Tubb5 Bpifb6 Gzmm Tnfaip3 Dync1h1 Lamp2 Leap2 Ube2d3 Defb25 Aprt Rnase2b Atp7a Chga Clu Itln1 Defb18 Cyld Ampd3 Gm15386 Pecam1 Pglyrp3 Defb36 Pglyrp4 Orm3 Pglyrp2 Eppin Impdh1 Art1 Defb29 Pglyrp1 Qsox1 Dnajc3 Rnase6 Bpifa1 Timp2 Ctss Cd63 Ctsg Defb15 Ctsb Reg3g Ctsk Defb19 Ctsl Defb14 Itgax Defb23 Bpifa2 Ctsd Defb12 Reg3b Slc11a1 Nos1 Vtn Nos2 Cd44 Mmp8 Dnajc5 Ckap4 Trex1 Pnp Cat Cdk13 Sigirr Hsp90b1 Irak3 Fth1 Ftl1 Cdc34 Ppp3cb Colec11 Rac1 Mapk8 Jun Card9 Pak1 Pycard Ppp3ca Rab31 Clec7a Nfatc2 Ppp3r1 Nfatc1 Nfatc3 Wasl Rab10 Ep300 Rab24 Apob Vamp8 H2-Q1 Tlr2 Tlr6 Dsg1a Dsp Glb1 Pkp1 Ube2k Cd36 Snap23 Tlr1 Tirap Tkfc Ms4a3 Adcy7 Ptges2 Adcy6 Adcy5 Lta4h Pros1 Adcy4 Adcy3 Adcy2 Prkar2a Adcy1 Frs2 Nras Snap29 Epx Prtn3 Pigr Frs3 Rasgrf1 Adcy9 Cd177 Psmf1 Adcy8 Raf1 Psme4 Acly Cd93 Il5ra Fgf1 Tmem63a Bad Il17rd Fgf2 Atad3a Tlr8 Cd68 Cnksr1 Tlr7 Ms4a2 Cnksr2 Erbb2 Fgf9 Pdap1 Ptk2 Fgf7 Psme3 Fgf6 Fgf4 Fgf3 Retn Cant1 Acpp Huwe1 Aga Abca13 Dhx36 Tnfaip6 Sugt1 Dbnl Taf6l Ppp5c Myo5a Prkar1a Rab27a Prkar1b Ranbp9 Lamtor1 Rap2c Atg12 Syngr1 Rap2b Cpped1 Ppp2cb Shc1 Lamtor2 Chuk Nrg2 Txn1 Ppp2ca Shc3 Nrg1 Akt2 Akt3 Shc2 Psma7 Artn Ptx3 Nrtn Plcg1 Olfm4 Asah1 Brap Psmb5 Psmb4 Mospd2 Ubc Nrg3 Psmb7 Nrg4 Itgal Psmb6 Psmb2 Psmb3 Psmb1 Nck1 Mapk3 Akt1 Mapk1 Ksr1 Cct2 Ptpra Ostf1 Dusp16 Dusp10 Map3k11 Pip4k2b Pip4k2a Trp53 Pip4k2c Actr10 Paqr3 Pik3ap1 Nbeal2 Pde1c Pde1b Psme2 Pde1a Psme1 Ncam1 Ubr4 Sos1 Rictor Braf Psmb10 Actr1b Stk11ip Apbb1ip Slc15a4 Crispld2 Ahcyl1 Gpi1 Dpp7 Psmb11 Csf2rb2 Rapgef2 Csf2ra Mov10 Cct8 Dock1 Ppie Rhoa Apeh Elmo1 Elmo2 Mapkapk2 Eef2 Casp8 Fadd Ripk1 Yes1 Lyn Capza1 Capza2 Socs1 Traf2 Ifnb1 Dock2 Hbb-bt Rbsn Npc2 Irf7 Irf1 Hbb-bs Irf2 Irf3 Ifna16 Polr2f Polr2e Polr2h Polr2k Crcp Polr3a Polr3gl Polr3k Polr3h Polr3f Polr3g Polr1d Polr1c Polr3d Polr3e Polr3b Polr3c Jup Sirpa Tyrobp Sirpb1b Mapk11 Mapk13 Mapk12 Mapk14 Cd47 Prkdc Pik3c3 Tmem173 Xrcc5 Tbk1 Ddx41 Xrcc6 Iqgap2 Nlrp4e Actb Mme Nlrc3 Pik3r4 Dtx4 Wipf3 Mavs Wipf2 Magt1 Rhof Wipf1 Wasf2 Wasf3 Arpc5 Arpc4 Wasf1 Diap1 Arg1 Myo9b Cybb Cyba Arsb Arsa Was Rnf135 Actg1 Ctsh Gdi2 Hmha1 Nckap1l Ctsa Abi1 Abi2 Aldoc Arpc1a Aldoa Arpc1b Slc44a2 Nckap1 Pfkl Pgam1 Cyfip1 Otud5 Pgm2 Cyfip2 Acaa1a Ncf4 Ncf2 Skp1a Ncf1 Cul1 Ddost Vrk3 Elk1 Mef2c Mef2a Dusp3 Trem1 Mapk7 Siglec15 Cd300e Klrd1 Klrk1 Clec5a Srp14 C5ar1 Rhog Rock1 Cd300lb Tlr9 Snap25 Ccr6 Rab3a Pcbp2 Txndc5 Gns Casp9 Prkcd Prkce Actn2 Nf1 Prkcg Tsc2 Pdgfrb Pdgfra Rab5c Rab5b Mlst8 Kbtbd7 Atp6ap2 Prkca Vav1 Il2rg Ikbke Tank Arrb2 Traf3 Egfr Gab1 Arrb1 Mtor Ret Phlpp1 Neu1 Adrbk1 Vwf Phlpp2 Rab3d Rab4b Mmp9 Rasgrp2 Rab37 Pspn Map2k1 Rbx1 Fgg Ltf Cdkn1a Map2k2 Cul3 Psmd12 Pdgfb Psmd11 Rasgef1a Igf2r Psmd14 Rasa3 Rasa4 Psmd13 Psmd10 Il2 Rasa2 Rasa1 Nefl Spred3 Kit Fpr2 Cfp Spred2 Grin2a Pafah1b2 Spred1 Il5 Ppp2r1b Ywhab Ago2 Ago1 Tnrc6c Kras Insr Gsk3a C3ar1 Rab7 Gsk3b Tnrc6b Gdnf Shfm1 Tnrc6a Ago4 Ago3 Itpr1 Surf4 Trat1 Rab9b Irs2 Mdm2 Syngap1 Pten Rab18 Hbegf Irs1 Il3ra Btc Il2ra Il2rb Rab6a Itpr3 Angpt1 Itpr2 Gsn Trib3 Psmc6 Egf Fgf23 Agl Psmc5 Fgf22 Mark3 Psmc2 Fgf20 Psmd2 Dab2ip Nos3 Prkacb Tek Psmb9 Psmb8 Araf Hras Grin1 Malt1 Hk3 Ppp2r5e Mapkap1 Card11 Dlg4 Pygl Ppp2r5c Rps6kb2 Ppp2r5d Ppp2r5a Psmc1 Psmc4 Psmc3 Gaa Pik3cb Foxo3 Pik3cd Foxo1 Itgb3 Pygb Fyn Hck Creb1 Myo1c Phb Fcgr4 Myh2 Grin2c Ppapdc1a Anpep Ppapdc1b Fgr Rasgrp4 Myo10 Plcg2 Cst3 Rasgrp3 Stat6 Bcl10 Mlec Pebp1 Camk4 Ppp2r5b Syk Rasgrp1 Fcgr3 Ier3 Fcgr1 Tln1 Pik3ca Cdkn1b Fga Fgb Grin2d Abl1 Grin2b Prkcsh Nr4a1 Prr5 Vav3 Hgf Gfra2 Gfra3 Pip5k1a Gfra4 Ereg Jak2 Trpm2 Pea15a Itga2b Rap1a Jak3 Wdr83 Btk Camk2d Rap1b Camk2a Fgfr4 Camk2b Psma5 Rasal3 Rasal2 Psma4 Ifih1 Psma3 Psma6 Akt1s1 Vcl Baiap2 Camk2g Psma2 Psma1 Gfra1 Brk1 Pip5k1b Cd19 Pip5k1c Psmd9 Dusp7 Iqgap1 Manba Man2b1 Actr2 Fgf16 Dusp6 Actr3 Dusp9 Fgf15 Dusp8 Klb Fgf18 Ncstn Them4 Psmd1 Met Fn1 Nckipsd Rasal1 Arhgap9 Dusp1 Psmd3 Psmd4 Pdpk1 Psmd6 Psmd5 Dusp2 Pik3r3 Psmd7 Arpc3 Crk Pik3r1 Dusp5 Arpc2 Nlrp3 Psmd8 Ddx58 Fgf10 Pik3r2 Gpr84 Dusp4 C2 Chit1 C8b C8a C8g Gm2a Cd46 Vcp Colec10 C5ar2 Akap9 Ppp2r1a Slco4c1 Isg15 Calm4 Panx1 Ube2l6 Trim25 Btrc Aldh3b1 Mapk9 Scamp1 Krt1 Nfkb2 Tax1bp1 Nfkb1 Ecsit Ptprj Fbxw11 S100a11 Saa3 Mapkapk3 Tnip2 Lrg1 Myd88 Pla2g6 Ano6 Nod2 Nod1 Lamp1 Dhx9 S100b Mapk10 Fuca2 Tlr5 Map3k7 Rnase2a Peli1 Irak2 Plekho2 Irak1 App Chil1 Tab1 Tab2 Nlrx1 Hc Tab3 Map3k1 Ripk2 Map2k7 Anxa2 Ager Map2k3 Hgsnat Map2k4 Dhx58 Map3k8 Tspan14 Bst2 Rela Uba7 Nfkbia Sell Csf2 Ilf2 Peli3 Nfkbib 2310033P09Rik Dsn1 Irak4 Peli2 Vapa Grn Lrmp Mefv Tnfrsf1b Cd86 Rnf216 Cxcr1 Glipr1 Jak1 Uba3 Fpr1 Atg7 Atg5 Psen1 Commd9 Map3k14 Cd80 Serpinb3d Ptafr Cxcr2 Relb Cxcl3 Pstpip1 Atp6v0d2 Atp6v0d1 Atp6v0b Ccr2 Ube2m Atp6v1c2 Atp6v1c1 Il1b Plac8 Pkm Atp6v0e Cmtm6 Atp6v1g3 Tbc1d10c Atp6v1e2 Rnaset2a Atp6v1e1 Plau Atp6v0e2 Atp6v1a Prcp Atp6v1b1 Tcirg1 Atp6v1b2 Vat1 Atp6v1g1 Atp6v1g2 Atp6v0a1 Atp6v0a2 Golga7 Elane Atp6v1h Lair1 Atp6v0a4 Adam8 Mmp25 Atp6v1d Atp6v1f Hebp2 9030624J02Rik Hp Erp44 Stk10 Prg2 Prg3 Ghdc Tmbim1 Sike1 Oscar Ypel5 Gca Qpct Nfam1 Nit2 Galns Alox5 Hexb Ndufc2 Kcnab2 Nhlrc3 Casp4 Tmem30a Serpinb6a Ptprn2 Fgl2 Commd3 Dnase1l1 Slpi Ormdl3 Lrrc7 Stom Frk Pdxk Serpinb1a Serpinb10 Serpinb12 Slc27a2 Plaur Hvcn1 Crp C1rb Flg2 Mbl2 Cstb Cd53 1600012H06Rik Siglece Tmc6 Ist1 Ppia Armc8 Ppbp Nlrp1a Txnip Gla Txk C1s2 C1qc Degs1 C1qb C1qa Tec Grap2 Fcnb Itk Lcp2 Naprt Pdzd11 Cyb5r3 Ins2 Trappc1 Bst1 Sptan1 Cd59b Lgmn Pld3 Dgat1 Ttr Cracr2a Prkcq Prss2 Mpo Ptprb Spta1 Lpcat1 Ptprc Sptbn4 Ticam2 Limk1 Ripk3 Ctsz Birc3 Bcl2 Birc2 Bcl2l1 Ticam1 Serpina1d Traf6 Ikbkb Trem2 Ube2v1 Tlr4 Ube2n Serpina1a Tlr3 Ly96 Pak3 Pak2 Cd14 Dync1li1 Ikbkg Cab39 Hsp90ab1 Pld2 Ctsc Pld1 Myh9 Pld4 Vnn1 Fuca1 Cpne3 Cpne1 Aim2 Mgst1 Pa2g4 Copb1 Cd300a Mif Unc13d Dok3 Gusb Aoc1 Hpse Lgals3 Mgam Sptbn2 Creg1 Sptbn1 Adgre5 Rab14 Padi2 Prdx4 Tollip Chrnb4 Mvp Lbp Fcer1a Mettl7a1 Adgrg3 Bin2 Faf2 B4galt1 Clec12a Kcmf1 Atp8a1 Pgrmc1 Clec4d Crisp1 Sptb Prdx6 Muc1 Muc4 Cd209a Clec4e Icam2 Bri3 Clec10a Muc15 Clec4a2 Fcer1g Cotl1 Clec4n Ddx3x Muc20 Clec4b2 Muc13 Cand1 Mcemp1 Dsc1 Tarm1 C6 Cfi C9 C7 Cfh Gsdmd Cystm1 Arl8a Agpat2 Olr1 Stbd1 Cnn2 Lat2 Enpp4 Atp11a Atp11b PRE-NOTCH PROCESSING IN GOLGI%REACTOME%R-HSA-1912420.2 Pre-NOTCH Processing in Golgi Notch4 Mfng Atp2a1 Atp2a3 Atp2a2 Rfng Lfng Notch3 Notch2 Furin B4galt1 Notch1 St3gal4 Sel1l Rab6a St3gal6 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS%REACTOME%R-HSA-2151201.2 Transcriptional activation of mitochondrial biogenesis Med1 Nr1d1 Ppara Tbl1x Helz2 Tfb1m Nrf1 Polrmt Ppargc1b Chd9 Ppargc1a Atp5b Alas1 Hcfc1 Mef2c Creb1 Esrra Ncor1 Tfam Tfb2m Rxra Crtc1 Mef2d Carm1 Mterf1b Atf2 Crebbp Ssbp1 Gabpa Smarcd3 Ncoa1 Sirt3 Polg2 Crtc3 Ncoa6 Crtc2 Tbl1xr1 Ncoa2 Peo1 Hdac3 Pprc1 SULFIDE OXIDATION TO SULFATE%REACTOME DATABASE ID RELEASE 59%1614517 Sulfide oxidation to sulfate Tst Ethe1 Suox Slc25a10 Sqrdl PLATELET CALCIUM HOMEOSTASIS%REACTOME DATABASE ID RELEASE 59%418360 Platelet calcium homeostasis Trpc6 Slc8a2 Slc8a1 P2rx4 P2rx5 Slc8a3 Stim1 Orai1 Atp2a1 Orai2 Atp2a3 Atp2a2 P2rx2 Itpr1 P2rx1 P2rx7 P2rx6 Atp2b3 Atp2b4 Atp2b1 Atp2b2 P2rx3 Sri Trpc3 Itpr3 Itpr2 Trpc7 DEFECTIVE EXT1 CAUSES EXOSTOSES 1, TRPS2 AND CHDS%REACTOME DATABASE ID RELEASE 59%3656253 Defective EXT1 causes exostoses 1, TRPS2 and CHDS Sdc3 Agrn Sdc4 Gpc6 Sdc2 Gpc3 Sdc1 Gpc5 Gpc2 Gpc4 Hspg2 Gpc1 FORMATION OF THE HIV-1 EARLY ELONGATION COMPLEX%REACTOME%R-HSA-167158.2 Formation of the HIV-1 Early Elongation Complex Gtf2h5 Gtf2h4 Gtf2h3 Ercc3 Ercc2 Polr2i Polr2f Polr2j Polr2e Nelfa Polr2h Nelfb Polr2c Mnat1 Polr2d Supt4a Polr2b Polr2k Polr2g Ctdp1 Ccnh Polr2a Cdk7 Nelfe Supt5 Nelfcd Gtf2h1 Gtf2f1 Ncbp1 Ncbp2 Gtf2h2 Gtf2f2 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS%REACTOME%R-HSA-451306.1 Ionotropic activity of Kainate Receptors Dlg4 Grik5 Grik1 Grik4 Dlg1 Grik3 Grik2 Ncald Dlg3 FGFR3 LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 59%190239 FGFR3 ligand binding and activation Fgf1 Fgf23 Fgf16 Fgf2 Fgf20 Fgf18 Fgf9 Galnt3 Fgf4 DEFECTIVE LFNG CAUSES SCDO3%REACTOME%R-HSA-5083630.1 Defective LFNG causes SCDO3 Notch4 Notch1 Notch3 Notch2 CAM PATHWAY%REACTOME%R-HSA-111997.1 CaM pathway Adcy7 Adcy6 Creb1 Prkcd Adcy5 Adcy4 Adcy3 Adcy2 Prkcg Prkar2a Adcy1 Prkacb Pde1c Camk4 Pde1b Adcy9 Pde1a Adcy8 Prkca Prkar2b Prkar1a Prkar1b Prkaca Adrbk1 DISSOLUTION OF FIBRIN CLOT%REACTOME DATABASE ID RELEASE 59%75205 Dissolution of Fibrin Clot Plau Serpine1 Serpinf2 Anxa2 Serpine2 Hrg Plg Serpinb8 Serpinb2 Plat S100a10 Serpinb6a Plaur SELENOAMINO ACID METABOLISM%REACTOME%R-HSA-2408522.2 Selenoamino acid metabolism Rpl39 Rplp1 Rpl7 Rps21 Rps27 Rplp2 Rps25 Rpl4 Rps26 Rps27l Cth Gnmt Rpl18a Nnmt Cbs Rpl34 Rpl32 Rpl26 Rpl24 Rps9 Rps7 Rps5 Rpsa Rpl37 Rps4x Papss2 Txnrd1 Papss1 Scly Ahcy Sepsecs Pstk Eefsec Dars Rars Eef1e1 Lars Aimp1 Secisbp2 Inmt Iars Sars Mars Aimp2 Eprs Qars Rpl22 Kars Rpl10l Rpl23 Rpl39l Rpl13a Hnmt Rpl22l1 Rps15a Rpl11 Rpl17 Rps3 Rpl19 Rpl18 Rps16 Rps14 Rps19 Rps18 Rps11 Rps10 Mat1a UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D%REACTOME DATABASE ID RELEASE 59%75815 Ubiquitin-dependent degradation of Cyclin D Psmc6 Psmc5 Psmc2 Psmd2 Psmd12 Psma7 Psmd11 Psmb9 Psmf1 Psmb8 Psma5 Psme4 Psmd14 Psmb5 Psmb4 Ubc Psmd13 Psma4 Psmd10 Psmb7 Psma3 Psma6 Psmb6 Psmb2 Psmc1 Psmb3 Psmc4 Psmb1 Psma2 Psmc3 Psma1 Cdk4 Psme3 Ccnd1 Psmd9 Psmd1 Shfm1 Psme2 Psme1 Psmd3 Psmd4 Psmb10 Psmd6 Psmd5 Psmd7 Psmb11 Psmd8 MOLYBDENUM COFACTOR BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 59%947581 Molybdenum cofactor biosynthesis Gphn Mocos Mocs3 Mocs2 FORMYL PEPTIDE RECEPTORS BIND FORMYL PEPTIDES AND MANY OTHER LIGANDS%REACTOME%R-HSA-444473.1 Formyl peptide receptors bind formyl peptides and many other ligands Fpr3 Fpr1 App Saa3 Hebp1 Fpr2 Anxa1 LINOLEIC ACID (LA) METABOLISM%REACTOME%R-HSA-2046105.1 Linoleic acid (LA) metabolism Abcd1 Fads1 Elovl1 Elovl5 Elovl3 Elovl2 Fads2 Acsl1 HIGHLY SODIUM PERMEABLE ACETYLCHOLINE NICOTINIC RECEPTORS%REACTOME DATABASE ID RELEASE 59%629587 Highly sodium permeable acetylcholine nicotinic receptors Chrnb2 Chrne Chrna4 Chrnb4 Chrnd Chrna3 Chrng RNA POLYMERASE I TRANSCRIPTION INITIATION%REACTOME%R-HSA-73762.2 RNA Polymerase I Transcription Initiation Gtf2h5 Gtf2h4 Cd3eap Ercc6 Rbbp7 Gtf2h3 Ercc3 Mta2 Polr1a Polr1e Znrd1 Hdac1 Taf1d Rbbp4 Chd3 Taf1c Chd4 Taf1b Taf1a Ercc2 Polr2f Polr2e Polr2h Hdac2 Tbp Mnat1 Ubtf Polr1b Gatad2a Rrn3 Gatad2b Mbd3 Polr2k Ehmt2 Ccnh Cdk7 Polr1d Polr1c Ttf1 Mta1 Gtf2h1 Kat2b Kat2a Mta3 Gtf2h2 TRIGLYCERIDE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 59%75109 Triglyceride Biosynthesis Gpd1 Acot8 Ppt2 Hsd17b3 Acly Hacd2 Hacd3 Hacd1 Agpat6 Gk2 Ppt1 Agpat5 Acsl3 Lclat1 Acsf3 Hsd17b12 Hacd4 Mogat1 Acsbg1 Acbd7 Lpcat4 Mogat2 Acsl6 Acbd6 Acsl5 Acot9 Fasn Acsl4 Acot7 Elovl7 Acsbg2 Agk Slc27a3 Acsl1 Elovl6 Tecr Gpam Tecrl Elovl1 Elovl5 Lpin2 Elovl4 Elovl3 Elovl2 Acot11 Acot12 Acot13 Lpin3 Lpin1 Olah Dgat2 Dgat1 Acaca Gyk Lpcat1 Slc25a1 Pctp Acot2 Acot3 Acot4 Dbi Agpat3 Scd1 Them4 Agpat4 Acsf2 Agpat1 Agpat2 Them5 Agpat9 Gpd1l Gpat2 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT%REACTOME DATABASE ID RELEASE 59%1428517 The citric acid (TCA) cycle and respiratory electron transport Ecsit Cox4i1 Atp5b Cyc1 Cox8a Uqcrc2 mt-Co3 Uqcrc1 mt-Co2 Uqcrfs1 Etfa Coq10b Uqcrb Coq10a Trap1 Uqcrq Etfdh mt-Cytb Uqcr10 Cox14 Cox7b Cox11 Cox16 Sco1 Cox18 Rxra Cox5a Ndufs5 Ndufs4 Ndufa13 Ndufs2 Ndufb11 Ndufb10 Etfb Ndufs7 Ndufs8 Ndufa11 Ndufs1 Ndufa10 Ndufa12 Ndufb2 Acad9 Ndufc2 Ndufc1 Ndufb4 Ndufb3 Ndufb6 Ndufb5 mt-Nd2 mt-Nd1 Timmdc1 Nubpl mt-Nd6 mt-Nd5 mt-Nd4 mt-Nd3 Atp5a1 Ndufaf1 Slc25a27 Ndufaf2 Ndufaf3 Ndufa1 Ndufa2 Ndufa3 Ndufa5 Lrpprc Ndufaf4 Ndufb9 Ndufb7 Yjefn3 Ndufb8 Slc25a14 Tmem126b Cox6a1 Ndufv3 Ucp1 Ndufv1 Ucp3 Ndufv2 Ucp2 mt-Co1 Slc16a3 Ndufab1 Ndufa6 Slc16a1 Ndufa7 Bsg Ndufaf5 Ndufaf6 Slc16a8 Ndufa8 Ppard Ndufa9 Cox6b1 Ndufaf7 Cox20 Ldhc Pdhb Dlat Adhfe1 Pdpr Glo1 Ldha Ldhb Pdp2 Cox7a2l Pdp1 Pdhx Atp5g3 Atp5k Atp5j Pdha1 mt-Atp6 D2hgdh Ldhal6b L2hgdh Pdk1 Pdk2 Mpc1 Mpc2 Ndufa4 Pdk3 Pdk4 Atp5s Dld Ogdh Idh3g Atp5d Atp5j2 Taco1 Atp5c1 Atp5f1 Sdhd Sdha Mdh2 Sdhc Suclg2 Suclg1 Sdhb Idh2 Idh3b Idh3a Surf1 Fh1 Sucla2 Nnt Dlst Aco2 Cs RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES%REACTOME DATABASE ID RELEASE 59%380270 Recruitment of mitotic centrosome proteins and complexes Pafah1b1 Ccp110 Nek2 Cep57 Akap9 Haus7 Haus8 Ppp2r1a Ywhag Ywhae Hsp90aa1 Ninl Ywhaq Cep152 Prkar2b Haus3 Haus4 Cdk1 Cetn2 Ofd1 Haus2 Cep63 Alms1 Haus5 Haus6 Haus1 Tubb4a Tubg2 Tubb4b Numa1 Clasp1 Ssna1 Tubg1 Csnk1d Cep250 Tuba4a Dynll1 Cdk11b Csnk1e Tubgcp5 Cep135 Tubgcp4 Tubgcp3 Cdk5rap2 Mapre1 Pcnt Sfi1 Cep70 Nedd1 Actr1a Cep131 Pcm1 Tubgcp2 Prkaca Dync1i2 Fgfr1op Cep76 Cep78 Cep72 Dctn2 Dctn3 Ckap5 Cep164 Tubb5 Tuba1a Cep41 Plk1 Cenpj Dync1h1 Plk4 Sdccag8 SUMOYLATION OF RNA BINDING PROTEINS%REACTOME DATABASE ID RELEASE 59%4570464 SUMOylation of RNA binding proteins Nup85 Hnrnpc Nup160 Nup37 Nup50 Nup43 Tpr Nup133 Ndc1 Nup214 Aaas Nup210 Nup188 Nup54 Nup35 Nupl2 Nup62 Rnf2 Nup205 Nup155 Nup88 Pom121 Hnrnpk Rae1 Ring1 Nup93 Phc3 Nup153 Phc2 Phc1 Cbx4 Pcgf2 Cbx8 Cbx2 Ranbp2 Bmi1 Nup107 Ube2i Nop58 CLASSICAL KIR CHANNELS%REACTOME%R-HSA-1296053.1 Classical Kir channels Kcnj2 Kcnj12 Kcnj4 Kcnj14 NEUROTRANSMITTER UPTAKE AND METABOLISM IN GLIAL CELLS%REACTOME DATABASE ID RELEASE 59%112313 Neurotransmitter uptake and Metabolism In Glial Cells Slc1a3 Slc1a2 Glul Slc38a1 PI3K AKT ACTIVATION%REACTOME%R-HSA-198203.2 PI3K AKT activation Casp9 Tsc2 Pdgfrb Pdgfra Ppp2r1a Mlst8 Vav1 Egfr Gab1 Mtor Rhoa Phlpp1 Ntrk1 Phlpp2 Ins2 Cd86 Cdkn1a Pdgfb Cd80 Kit Ppp2r1b Ago2 Ago1 Tnrc6c Insr Gsk3a Gsk3b Tnrc6b Tnrc6a Ago4 Ago3 Trat1 Irs2 Mdm2 Lck Pten Hbegf Irs1 Btc Ptpn11 Trib3 Egf Fgf23 Fgf22 Fgf20 Frs2 Ppp2r5e Mapkap1 Fgf1 Bad Ppp2r5c Fgf2 Rps6kb2 Ppp2r5d Ppp2r5a Erbb2 Fgf9 Pik3cb Fgf7 Foxo3 Pik3cd Fgf6 Foxo1 Fgf4 Fgf3 Fyn Creb1 Ppp2r5b Ier3 Pik3ca Cdkn1b Nr4a1 Prr5 Hgf Ppp2cb Pip5k1a Chuk Ereg Nrg2 Ppp2ca Nrg1 Akt2 Akt3 Fgfr4 Nrg3 Nrg4 Akt1s1 Mapk3 Pip5k1b Akt1 Mapk1 Cd19 Pip5k1c Ngf Fgf16 Pip4k2b Pip4k2a Fgf15 Trp53 Pip4k2c Klb Fgf18 Pik3ap1 Them4 Met Rictor Pdpk1 Pik3r3 Pik3r1 Fgf10 Pik3r2 Mov10 P75NTR REGULATES AXONOGENESIS%REACTOME DATABASE ID RELEASE 59%193697 p75NTR regulates axonogenesis Ngf Arhgdia Mag Rhoa Arhgef1 Lingo1 Rtn4 Ngfr Omg FORMATION OF THE ACTIVE COFACTOR, UDP-GLUCURONATE%REACTOME%R-HSA-173599.1 Formation of the active cofactor, UDP-glucuronate Slc35d1 Ugdh Ugp2 FBXL7 DOWN-REGULATES AURKA DURING MITOTIC ENTRY AND IN EARLY MITOSIS%REACTOME%R-HSA-8854050.2 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis Psmc6 Psmc5 Psmc2 Psmd2 Psmb9 Psmb8 Psmf1 Psme4 Skp1a Psmc1 Psmc4 Psmc3 Cul1 Psme3 Aurka Fbxl7 Fbxl18 Rbx1 Psmd12 Psma7 Psmd11 Psmd14 Psma5 Psmb5 Psmb4 Psmd13 Ubc Psmd10 Psma4 Psma3 Psmb7 Psma6 Psmb6 Psmb2 Psmb3 Psma2 Psmb1 Psma1 Psmd9 Psmd1 Shfm1 Psme2 Psme1 Psmd3 Psmd4 Psmb10 Psmd6 Psmd5 Psmd7 Psmb11 Psmd8 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION%REACTOME DATABASE ID RELEASE 59%504046 RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription Mbd2 Brf2 Ercc6 Pou2f1 Nfix Polr1a Zfp143 Polr1e Hdac1 H2afj H2afb2 Hdac2 Mnat1 Ubtf Polr1b Mterf1b Ptrf Hist2h2be Cbx3 Hist2h2ac Mta1 Kat2b H3f3b Kat2a Mta3 H3f3a Hist1h2bg Hist1h2bh Cd3eap Nfia Nfic Ssb Hist1h2bp Hist1h2bm Hist1h2bj Rbbp7 Hist1h2bb Ercc3 Polrmt Ercc2 Gatad2a Rrn3 Gatad2b Hist1h3d Hist1h2ak Hist1h2ag Hist1h2ah Hist2h3c1 Znrd1 Rbbp4 Chd3 Chd4 Polr2f Polr2e Polr2h Tbp Tfam Gtf3c1 Gtf3c6 Gtf3c3 Gtf3c2 Bdp1 Mbd3 Gtf3c4 Polr2k Crcp Polr3a Polr3gl Polr3k Polr3h Brf1 Hist3h2ba Polr3f Polr3g Gtf3c5 Polr1d Ttf1 Polr1c Polr3d Polr3e Gtf2h1 Polr3b Gtf3a Polr3c Gtf2h2 Gtf2h5 Gtf2h4 Gtf2h3 Mta2 H2afz Taf1d H2afx Taf1c Taf1b Mapk3 Taf1a Hist2h2aa1 Tfb2m Snapc2 Ehmt2 Snapc1 Snapc4 Ccnh Snapc5 Cdk7 Snapc3 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 59%196849 Metabolism of water-soluble vitamins and cofactors Mccc2 Mthfr Mccc1 Btd Tpk1 Slc52a3 Slc52a2 Slc23a1 Slc25a32 Shmt2 Shmt1 Slc23a2 Nnmt Mthfsl Mthfd2 Fasn Mthfd1 Aldh1l2 Naprt Ppcs Rfk Pdzd11 Cyb5r3 Apoa1bp Nampt Aldh1l1 Bst1 Nt5e Hlcs Parp8 Slc5a8 Slc5a6 Coasy Qprt Nmrk2 Thtpa Ptgis Acacb Slc46a1 Nmrk1 Mocos Pcca Ptgs2 Acaca Ctrb1 Mthfd2l Acp5 Pccb Prss2 Nadsyn1 Mmab Ctrc Cyb5a Folr2 Enpp3 Parp14 Pcx Parp16 Enpp1 Cd38 Enpp2 Parp10 Mthfd1l Nmnat2 Nmnat1 Nmnat3 Abcc1 Gsto1 Gsto2 Gphn Aasdhppt Nudt12 Ppcdc Vnn3 Vnn1 Slc22a13 Slc2a3 Dhfr Slc2a1 Pdxk Pnpo Aox1 Nadk Slc19a2 Slc19a1 Slc25a19 Pank4 Mocs3 Mocs2 Pank1 Parp6 Pank3 Pank2 Parp9 Lmbrd1 Parp4 Flad1 Abcd4 Cyp8b1 Slc25a16 Mmachc Gif Amn Mut Mtrr Cd320 Cubn Mmadhc Mmaa Tcn2 Mtr DOWNSTREAM SIGNALING OF ACTIVATED FGFR3%REACTOME%R-HSA-5654708.1 Downstream signaling of activated FGFR3 Fgf23 Fgf16 Kras Fgf20 Frs2 Fgf18 Nras Frs3 Plcg1 Hras Pik3ca Sos1 Fgf1 Gab1 Fgf2 Fgf9 Pik3r1 Ptpn11 Fgf4 SIGNALING BY RAS MUTANTS%REACTOME%R-HSA-6802949.1 Signaling by RAS mutants Map2k1 Nf1 Fgg Mark3 Jak2 Map2k2 Itga2b Rap1a Nras Dab2ip Rap1b Araf Brap Hras Raf1 Rasal3 Rasa3 Arrb2 Rasa4 Rasal2 Arrb1 Cnksr1 Csk Rasa2 Cnksr2 Rasa1 Vcl Vwf Mapk3 Mapk1 Itgb3 Ksr1 Ywhab Phb Iqgap1 Map3k11 Kras Pebp1 Fn1 Tln1 Rasal1 Braf Syngap1 Apbb1ip Fga Fgb P75NTR SIGNALS VIA NF-KB%REACTOME DATABASE ID RELEASE 59%193639 p75NTR signals via NF-kB Ngf Irak1 Traf6 Ikbkb Ripk2 Sqstm1 Rela Nfkbia Ubc Nfkb1 Prkci Myd88 Ngfr PTK6 REGULATES CELL CYCLE%REACTOME%R-HSA-8849470.1 PTK6 Regulates Cell Cycle Ccne1 Cdk2 Cdkn1b Cdk4 Ccnd1 Ptk6 RNA POLYMERASE I CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 59%73777 RNA Polymerase I Chain Elongation Hist2h3c1 Polr1a Polr1e Znrd1 H2afj Polr2f H2afb2 Polr2e Polr2h Tbp Mnat1 Ubtf Polr1b Polr2k Hist3h2ba Hist2h2be Polr1d Cbx3 Polr1c Hist2h2ac Gtf2h1 H3f3b H3f3a Gtf2h2 Hist1h2bg Hist1h2bh Gtf2h5 Gtf2h4 Cd3eap Hist1h2bp Hist1h2bm Hist1h2bj Hist1h2bb Gtf2h3 Ercc3 H2afz Taf1d H2afx Taf1c Taf1b Taf1a Ercc2 Hist2h2aa1 Hist1h3d Ccnh Hist1h2ak Hist1h2ag Cdk7 Hist1h2ah RECYCLING OF BILE ACIDS AND SALTS%REACTOME%R-HSA-159418.2 Recycling of bile acids and salts Alb Fabp6 Rxra Baat Abcb11 Nr1h4 Stard5 Slc27a5 Slc10a2 Slc10a1 Slco1a4 Ncoa1 Slco1b2 Ncoa2 Abcc3 EUKARYOTIC TRANSLATION INITIATION%REACTOME%R-HSA-72613.2 Eukaryotic Translation Initiation Rpl39 Rplp1 Eif2s1 Eif2s2 Eif3i Eif3k Eif3l Eif3m Rpl7 Rps21 Rplp2 Rps27 Eif3a Eif3b Eif3c Rps25 Rpl4 Eif3d Rps26 Rps27l Eif3e Rpl18a Rpl34 Rpl32 Eif3f Eif3h Eif3g Rpl26 Rpl24 Rps9 Eif2s3x Rps7 Rps5 Rpsa Rpl37 Rps4x Eif4b Eif5 Eif5b Eif2b5 Eif2b4 Eif2b3 Eif2b2 Eif2b1 Eif4a1 Eif4a2 Rpl22 Eif1ax Rpl10l Rpl23 Rpl39l Eif3j2 Rpl13a Rpl22l1 Rps15a Rpl11 Rpl17 Rps3 Rpl19 Rpl18 Rps16 Eif4e Rps14 Rps19 Rps18 Eif4h Pabpc1 Rps11 Eif4g1 Rps10 Eif4ebp1 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1%REACTOME DATABASE ID RELEASE 59%450321 JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 Map3k7 Irak2 Irak1 Tab1 Tab2 Traf6 Tab3 Mapk8 Ube2v1 Ripk2 Map2k7 Ube2n Map2k4 Ikbkg Mapk9 Nod2 Nod1 Mapk10 DCC MEDIATED ATTRACTIVE SIGNALING%REACTOME DATABASE ID RELEASE 59%418885 DCC mediated attractive signaling Fyn Ablim1 Dock1 Wasl Rac1 Trio Ntn1 Dcc Ptk2 Nck1 Ablim3 Ablim2 FBXW7 MUTANTS AND NOTCH1 IN CANCER%REACTOME DATABASE ID RELEASE 59%2644605 FBXW7 Mutants and NOTCH1 in Cancer Rbx1 Notch1 Skp1a Cul1 MINUS-STRAND DNA SYNTHESIS%REACTOME DATABASE ID RELEASE 59%164516 Minus-strand DNA synthesis Ppia PTK6 REGULATES RTKS AND THEIR EFFECTORS AKT1 AND DOK1%REACTOME%R-HSA-8849469.1 PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 Ubc Cbl Dok1 Akt1 Ptk6 Arap1 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX)%REACTOME%R-HSA-2142691.1 Synthesis of Leukotrienes (LT) and Eoxins (EX) Cyp4a12b Mapkapk2 Lta4h Ptgr1 Ggt1 Dpep1 Dpep2 Alox15 Dpep3 Ltc4s Cyp4f18 Cyp4f17 Alox5 Abcc1 Cyp4f15 Cyp4b1 Alox5ap Cyp4f40 Cyp4a32 Cyp4f39 Ggt5 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME DATABASE ID RELEASE 59%2122947 NOTCH1 Intracellular Domain Regulates Transcription Rbx1 Tbl1x Hdac4 Hdac5 Maml3 Cdk8 Ccnc Ubc Notch1 Skp1a Myc Hdac1 Cul1 Maml2 Hif1a Maml1 Hdac2 Ncor1 Ncor2 Tle1 Tle4 Tle2 Hdac10 Crebbp Hey1 Hdac11 Mamld1 Hey2 Ep300 Hdac7 Hdac6 Hdac9 Hdac8 Rbpj Hes5 Kat2b Kat2a Heyl Tbl1xr1 Hes1 Hdac3 RNA POLYMERASE II TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 59%73856 RNA Polymerase II Transcription Termination Pabpn1 Srsf2 Thoc7 Thoc6 Srsf3 Zfp473 Slu7 Srsf11 Zc3h11a Magoh Cpsf1 Cstf1 Dhx38 Clp1 Thoc3 Srsf7 Thoc2 Thoc5 Thoc1 Srsf9 Ncbp1 Alyref Ncbp2 Srsf6 Nudt21 Cstf2t Fip1l1 Rbm8a Cstf3 Casc3 Sympk Eif4a3 U2af1l4 Chtop Srsf1 Cstf2 Cpsf3 Cpsf2 Cpsf4 Cpsf7 Lsm11 Ddx39b Upf3b Ddx39 Papola Fyttd1 Wdr33 Rnps1 Poldip3 Lsm10 Magohb Snrpb Snrpd3 Cdc40 Slbp Srrm1 PHASE 1 - INACTIVATION OF FAST NA+ CHANNELS%REACTOME DATABASE ID RELEASE 59%5576894 Phase 1 - inactivation of fast Na+ channels Kcnip4 Kcnd3 Kcnip1 Kcnd2 Kcnip3 Kcnd1 GOLGI-TO-ER RETROGRADE TRANSPORT%REACTOME DATABASE ID RELEASE 59%8856688 Golgi-to-ER retrograde transport Zw10 Pla2g6 Rab1 Copa Klc3 Klc2 Klc4 Tmed3 Racgap1 Arcn1 Cenpe Kif2c Stx18 Kif2b Kif18a Rab3gap1 Kif3c Nsf Kif3b Kif3a Kif2a Tmed9 Kif18b Gbf1 Napb Bicd2 Napg Bicd1 Kifc5b Klc1 Pafah1b3 Napa Kifc2 Pafah1b2 Dctn5 Kif16b Dctn6 Kif26a Dctn1 Dctn4 Dync1li2 Kif26b Dync1li1 Kif13b Rab1b Kif20b Surf4 Kif4 Arf5 Kif20a Kdelr2 Galnt1 Kdelr3 Galnt2 Rab18 Kifap3 Rint1 Bnip1 Kif22 Rab6b Rab6a Kif27 Kif23 Use1 Kif9 Arfgap3 Pafah1b1 Arfgap1 Arfgap2 Kif12 Kif15 Copb2 Kif19a Kif6 Kif1c Copb1 Kif21a Kif21b Copz1 Kif1b Kif1a Copz2 Copg1 Dynll2 Arf1 Kdelr1 Arf3 Pla2g4a Kif11 Arf4 Dync1i1 Dynll1 Cope Dync1i2 Sec22b Dctn2 Dctn3 Dync1h1 Kif5a Kif5b Agpat3 CATABOLISM OF GLUCURONATE TO XYLULOSE-5-PHOSPHATE%REACTOME DATABASE ID RELEASE 59%5661270 Catabolism of glucuronate to xylulose-5-phosphate Cryl1 Sord Xylb Akr1a1 Dcxr E3 UBIQUITIN LIGASES UBIQUITINATE TARGET PROTEINS%REACTOME%R-HSA-8866654.1 E3 ubiquitin ligases ubiquitinate target proteins Prkdc Hist1h2bg Ube2b Hist1h2bh Paf1 Wac Ube2a Hist1h2bp Hist1h2bm Hist1h2bj Rraga Hist1h2bb Ube2d3 Ubc Ctr9 Cdc73 Ube2d1 Rtf1 Bcl10 Ube2n Ube2e1 Rnf181 Rnf20 Rnf144a Rnf40 Hist3h2ba Hist2h2be Leo1 Wdr61 Ube2l3 Rnf152 TRNA PROCESSING IN THE MITOCHONDRION%REACTOME%R-HSA-6785470.4 tRNA processing in the mitochondrion 1110008L16Rik Elac2 Trmt10c Hsd17b10 Trnt1 MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 59%397014 Muscle contraction Abcc9 Cacng8 Actn2 Cacng4 Cacng3 Akap9 Cacng2 Gata4 Anxa2 Actn3 Nkx2-5 Scn1a Scn1b Kat2b Anxa6 Scn2a1 Scn5a Dysf Myl6b Scn9a Anxa1 Myl6 Myh11 Scn2b Tbx5 Scn10a Hipk1 Scn3a Hipk2 Scn3b Scn11a Myl12b Itpr1 Myl12a Scn7a Itga1 Scn8a Scn4b Scn4a Itpr3 Vim Itpr2 Stim1 Myh6 Trpc1 Myh8 Orai1 Orai2 Tln1 Myh3 Sorbs3 Lmod1 Myl10 Acta2 Cav3 Myl7 Trim72 Sorbs1 Prkaca Fxyd7 Mylpf Kcnh2 Tmod2 Fxyd1 Tmod3 Fxyd4 Tnnt2 Fxyd6 Tnnt1 Cacng6 Mybpc3 Kcnip4 Tpm2 Cacng1 Tmod4 Cacng5 Des Kcnq1 Tmod1 Kcnip1 Tpm3 Cacng7 Neb Kcnip3 Mybpc1 Camk2d Atp1a1 Myl2 Slc8a2 Myl3 Camk2a Slc8a1 Mybpc2 Kcne1l Myl4 Camk2b Fkbp1b Atp1b2 Atp1a2 Atp1a3 Pxn Slc8a3 Cacna1s Atp1b3 Atp1b1 Vcl Kcnd3 Ttn Camk2g Wwtr1 Dmpk Kcnd2 Cacna1f Tnni2 Kcnd1 Tnni1 Ryr3 Tnnt3 Ryr1 Ryr2 Kcne4 Kcne3 Kcne2 Kcne1 Atp2a1 Trdn Atp2a3 Kcnk1 Dmd Kcnk12 Atp2a2 Cacnb2 Npr2 Cacnb3 Asph Cacna2d2 Mylk Npr1 Cacna1c Fgf14 Cacna1d Fgf13 Fgf11 Nppc Fgf12 Kcnj11 Kcnj2 Myl1 Cacna2d1 Kcnk15 Nos1 Cacna2d4 Tcap Itgb5 Kcnj12 Tnnc2 Cacna2d3 Nppa Tnnc1 Kcnk9 Atp2b3 Atp2b4 Kcnj4 Kcnk7 Atp2b1 Kcnk6 Corin Ahcyl1 Kcnk5 Atp2b2 Kcnk2 Cacnb4 Kcnk13 Cacnb1 Kcnk3 Sri Kcnk10 Tnni3 Kcnk4 Kcnk18 Kcnk16 Kcnj14 INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS%REACTOME%R-HSA-176033.2 Interactions of Vpr with host cellular proteins Nup85 Nup160 Nup37 Nup50 Hmga1 Tpr Nup43 Nup133 Ndc1 Nup214 Aaas Nup210 Nup188 Nup54 Nup35 Nupl2 Nup62 Nup205 Nup155 Nup88 Pom121 Rae1 Nup93 Nup153 Slc25a4 Kpna1 Psip1 Ranbp2 Banf1 Nup107 Slc25a5 VIRAL MESSENGER RNA SYNTHESIS%REACTOME%R-HSA-168325.2 Viral Messenger RNA Synthesis Nup85 Nup160 Nup37 Nup50 Nup43 Tpr Nup133 Ndc1 Nup214 Aaas Nup210 Nup188 Nup54 Nup35 Nupl2 Nup62 Nup205 Nup155 Nup88 Pom121 Rae1 Polr2i Polr2f Polr2j Polr2e Polr2h Nup93 Polr2c Polr2d Nup153 Polr2b Polr2k Polr2g Ranbp2 Nup107 Polr2a Gtf2f1 Gtf2f2 SMOOTH MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 59%445355 Smooth Muscle Contraction Anxa6 Dysf Myl6b Tpm2 Tpm3 Anxa1 Myl6 Pxn Myh11 Vcl Mylk Anxa2 Tln1 Myl12b Sorbs3 Lmod1 Myl10 Myl12a Itgb5 Acta2 Cav3 Myl7 Trim72 Itga1 Sorbs1 Mylpf TRAIL SIGNALING%REACTOME DATABASE ID RELEASE 59%75158 TRAIL signaling Casp8 Fadd Tnfrsf10b Tnfsf10 Cflar HEXOSE UPTAKE%REACTOME DATABASE ID RELEASE 59%189200 Hexose uptake Hk1 Nup85 Slc5a2 Nup160 G6pc2 Slc5a3 Nup37 Slc5a1 G6pc3 Nup50 Nup43 Tpr Slc5a9 Nup133 Slc5a4a Hk2 Ndc1 Slc2a5 Nup214 Hk3 Aaas Nup210 Nup188 Nup54 Nup35 Nupl2 Slc2a4 Nup62 Slc2a3 Nup205 Nup155 Slc2a2 Nup88 Slc2a1 Slc37a4 Pom121 Slc45a3 Slc5a10 Rae1 Fgf21 Nup93 Nup153 Gckr Slc50a1 G6pc Ranbp2 Nup107 Gck RELAXIN RECEPTORS%REACTOME DATABASE ID RELEASE 59%444821 Relaxin receptors Insl5 Rxfp4 Rxfp3 Insl3 Rln3 Rln1 Rxfp1 Rxfp2 INHIBITION OF HOST MRNA PROCESSING AND RNA SILENCING%REACTOME DATABASE ID RELEASE 59%168315 Inhibition of Host mRNA Processing and RNA Silencing Pabpn1 Cpsf4 MASTL FACILITATES MITOTIC PROGRESSION%REACTOME DATABASE ID RELEASE 59%2465910 MASTL Facilitates Mitotic Progression Ppp2cb Ppp2r1b Arpp19 Mastl Cdk1 Ppp2r2d Ppp2ca Ppp2r1a Ensa NEGATIVE REGULATION OF MET ACTIVITY%REACTOME%R-HSA-6807004.1 Negative regulation of MET activity Ptpn1 Ptpn2 Met Sh3kbp1 Usp8 Ubc Cbl Ptprj Sh3gl2 Sh3gl1 Stam Lrig1 Hgs Stam2 Hgf Eps15 SIGNALING BY MET%REACTOME%R-HSA-6806834.2 Signaling by MET Itgb1 Hgfac Ptpn2 Nras Hras Usp8 Ptprj Gab1 Spint1 Hpn Ptk2 Spint2 Arf6 Itga3 Rac1 Src Tns4 Lamc3 Tns3 Rab4b Sh3kbp1 Pik3ca Ranbp9 Lama3 Sh3gl1 Stam Hgs Stam2 Hgf Eps15 Ptpn1 Lamc1 Crkl Muc20 Rap1a Rap1b Dock7 Stat3 Ubc Cbl Lamb1 Sh3gl2 Lama5 Lama2 Lama4 Gga3 Rab4a Kras Lamb3 Lama1 Lamb2 Met Sos1 Ranbp10 Itga2 Lrig1 Crk Pik3r1 Rapgef1 Ptpn11 Lamc2 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS%REACTOME DATABASE ID RELEASE 59%168643 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Casp9 Aim2 Panx1 Nfkb2 Nfkb1 Casp4 Nod2 Nlrc4 Nod1 Map3k7 Irak2 Irak1 App Tab1 Map2k6 Tab2 Tab3 Card9 Ripk2 Pycard Sugt1 Rela P2rx7 Mefv Casp8 Chuk Txn1 Tnfaip3 Itch Pstpip1 Cyld Birc3 Bcl2 Birc2 Bcl2l1 Nlrp1a Traf6 Ikbkb Ube2v1 Ube2n Txnip Ikbkg Mapk11 Mapk13 Mapk12 Mapk14 Hsp90ab1 Casp1 Nlrp3 Casp2 MET ACTIVATES PI3K AKT SIGNALING%REACTOME DATABASE ID RELEASE 59%8851907 MET activates PI3K AKT signaling Gab1 Pik3r1 Met Hgf Pik3ca CROSS-PRESENTATION OF PARTICULATE EXOGENOUS ANTIGENS (PHAGOSOMES)%REACTOME DATABASE ID RELEASE 59%1236973 Cross-presentation of particulate exogenous antigens (phagosomes) Ncf4 Cd36 Itgb5 Cybb Ncf2 Cyba Ncf1 Itgav SIALIC ACID METABOLISM%REACTOME%R-HSA-4085001.1 Sialic acid metabolism St6galnac6 St6galnac5 St6galnac4 St6galnac3 St8sia3 St6gal2 St8sia2 St8sia6 St3gal4 Ctsa St6galnac1 Neu1 Neu3 Neu2 Neu4 St6galnac2 Cmas Glb1 St8sia1 Slc35a1 Slc17a5 Gne Npl St3gal1 Nans St3gal2 Nanp St8sia5 St8sia4 St6gal1 St3gal5 St3gal6 SYNTHESIS OF DIPHTHAMIDE-EEF2%REACTOME%R-HSA-5358493.1 Synthesis of diphthamide-EEF2 Dph3 Dph2 Dph1 Dph7 Dph6 Eef2 Dph5 Dnajc24 RRNA MODIFICATION IN THE NUCLEUS AND CYTOSOL%REACTOME%R-HSA-6790901.3 rRNA modification in the nucleus and cytosol Dkc1 Nhp2 Ddx52 Trmt112 Noc4l Rrp36 Pdcd11 Ddx49 Ddx47 Krr1 Pwp2 Rps9 Heatr1 Rps7 Imp4 Utp18 Imp3 Mphosph10 Utp11l Utp15 Nol11 Diexf Dcaf13 Wbscr22 Cirh1a Utp14a Nop56 Rrp9 Dimt1 Nol6 Utp3 Utp6 Nop58 Bms1 Utp20 Dhx37 Nop10 Nop2 Wdr75 Rcl1 Nop14 Nat10 Gar1 Thumpd1 Tbl3 Fbl Tsr3 Wdr3 Rps14 Wdr43 Wdr46 Emg1 SLC TRANSPORTER DISORDERS%REACTOME DATABASE ID RELEASE 59%5619102 SLC transporter disorders Alb Avp Avpr1a Avpr2 Avpr1b Gckr Gck AXON GUIDANCE%REACTOME%R-HSA-422475.3 Axon guidance Agrn Actb Pfn2 Pfn1 Arpc5 Arpc4 Dok2 Sos2 Trio Scn1a Scn1b Shtn1 Nrcam Rdx Gap43 Scn2a1 Scn5a Srgap2 Lamc1 Ap2m1 Arhgap39 Nrp1 Csnk2a2 Actg1 Scn9a Hspa8 Dlg1 Kcnq3 Nrp2 Sdcbp Cntnap1 Srgap3 Cntn6 Ap2a1 Srgap1 Dlg3 Kcnq2 Ap2a2 Msn Scn2b Cntn1 Cntn2 Lamb1 Sh3gl2 Itgav Dnm2 Scn10a Lypla2 Ephb2 Rps6ka5 Ap2s1 Dnm1 Chl1 Rps6ka6 Rps6ka4 Arhgef7 Arpc1a Rps6ka3 Rps6ka2 Rps6ka1 Arpc1b Scn3a Scn3b Slit1 Lama1 Slit3 Scn11a L1cam Hfe2 Rgma Vav2 Clta Rgmb Ap2b1 Agap2 Csnk2b Ablim3 Ezr Ablim2 Alcam Kif4 Ablim1 Cltc Numb Scn7a Dnm3 Dpysl2 Itga1 Itga2 Scn8a Scn4b Dok5 Dok6 Itga9 Itsn1 Scn4a Itga10 Dok4 Itga5 Dcx Nfasc Csk Mapk7 Rhog Rhob Rock1 Rhoc Rock2 Adam10 Gab2 Cacna1s Ntn4 Cacnb4 Cacnb1 Grb7 Actn2 Nf1 Pdgfrb Siah1a Pdgfra Efna2 Efna1 Kbtbd7 Efna3 Prkca Il2rg Arrb2 Egfr Gab1 Arrb1 Ret Siah2 Vwf Aph1b Efna4 Efnb3 Arhgef28 Efnb1 Efna5 Epha1 Mmp2 Mmp9 Epha3 Epha2 Epha6 Epha7 Git1 Epha8 Ephb1 Ephb4 Epha4 Epha5 Ephb6 Efnb2 Ephb3 Cltb Pspn Col4a5 Map2k1 Rbx1 Fgg Map2k2 Cul3 Psmd12 Pdgfb Neo1 Psmd11 Col9a1 Rasgef1a Col9a2 Col9a3 Psmd14 Rasa3 Rasa4 Psmd13 Psmd10 Il2 Rasa2 Rasa1 Nefl Spred3 Kit Ncan Spred2 Kdr Grin2a Spred1 Il5 Ppp2r1b Ywhab Kras Unc5b Gsk3b Gdnf Shfm1 Unc5a Irs2 Syngap1 Hbegf Irs1 Il3ra Btc Il2ra Il2rb Ptpn11 Angpt1 Psmc6 Egf Fgf23 Psmc5 Fgf22 Mark3 Psmc2 Fgf20 Psmd2 Dab2ip Prkacb Tek Psmb9 Slit2 Hsp90aa1 Psmb8 Abl2 Araf Cap2 Hras Grb10 Grin1 Shb Ppp2r5e Dlg4 Ppp2r5c Ppp2r5d Ppp2r5a Psmc1 Psmc4 Psmc3 Pik3cb Pik3cd Itgb3 Cacna1i Fyn Cacna1h Creb1 Phb Trpc1 Clasp1 Grin2c Cacna1g Rasgrp4 Prnp Rasgrp3 Myo10 Pebp1 Ngef Ppp2r5b Rasgrp1 Tln1 Pik3ca Pak7 Col4a3 Robo2 Col4a2 Pak4 Robo1 Col4a4 Col4a1 Fga Fgb Pak6 Grin2d Prkaca Abl1 Grin2b Vav3 Hgf Gfra2 Gfra3 Gfra4 Ereg Jak2 Cap1 Pea15a Trpc4 Itga2b Rap1a Jak3 Wdr83 Camk2d Trpc5 Rap1b Camk2a Fgfr4 Camk2b Psma5 Rasal3 Rasal2 Psma4 Psma3 Psma6 Vcl Camk2g Psma2 Psma1 Gfra1 Pip5k1c Evl Psmd9 Tiam1 Dusp7 Iqgap1 Fgf16 Actr2 Actr3 Dusp6 Dusp9 Fgf15 Dusp8 Klb Psen2 Fgf18 Kalrn Ncstn Psmd1 Met Fn1 Rasal1 Dusp1 Psmd3 Psmd4 Psmd6 Psmd5 St8sia4 Dusp2 Pik3r3 Arpc3 Psmd7 Pik3r1 Arpc2 Dusp5 Psmd8 Fgf10 Pik3r2 Dusp4 Trpc6 Akap9 Rap1gap Ppp2r1a Clasp2 Dok1 Rac1 Pak1 Csf2 Wasl Dcc Trpc3 Trpc7 Jak1 Unc5c Unc5d Frs2 Nras Frs3 Rasgrf1 Psmf1 Raf1 Psme4 Il5ra Fgf1 Il17rd Fgf2 Cnksr1 Cnksr2 Erbb2 Fgf9 Ptk2 Fgf7 Psme3 Fgf6 Fgf4 Fgf3 Shank3 Ppp5c Ranbp9 Ppp2cb Shc1 Lamtor2 Nrg2 Ppp2ca Shc3 Nrg1 Shc2 Psma7 Artn Nrtn Plcg1 Brap Nck2 Psmb5 Psmb4 Ubc Nrg3 Psmb7 Nrg4 Psmb6 Psmb2 Psmb3 Psmb1 Nck1 Mapk3 Mapk1 Ksr1 Ptpra Dusp16 Dusp10 Map3k11 Cacnb2 Paqr3 Cacnb3 Cacna1c Cacna1d Psme2 Psme1 Ncam1 Sos1 Braf Psmb10 Apbb1ip Col6a1 Col6a2 Col6a3 Col6a6 Psmb11 Csf2rb2 Rapgef2 Csf2ra Dock1 Rhoa Arhgap35 Sptan1 St8sia2 Yes1 Sema6a Lyn Sema6d Myl6 Myh11 Prkcq Dpysl5 Dpysl3 Farp2 Cd72 Myh14 Cdk5r1 Spta1 Myh10 Dpysl4 Ptprc Sptbn4 Limk1 Arhgef11 Limk2 Arhgef12 Plxnd1 Plxnc1 Sema5a Trem2 Plxnb3 Rras Plxnb1 Pak3 Pak2 Crmp1 Rnd1 Myl12b Plxna2 Myl12a Sema3e Sema4a Rac2 Sema4d Hsp90ab1 Sema7a Fes Plxna4 Plxna3 Myh9 Cdk5 Plxna1 Sema3a Itgb1 Ank1 Ank3 Sptbn2 Sptbn1 Sptb Pitpna Tyrobp Ntn1 Sdc2 Vasp Gpc1 SPHINGOLIPID DE NOVO BIOSYNTHESIS%REACTOME%R-HSA-1660661.5 Sphingolipid de novo biosynthesis Ormdl2 Vapb Ppap2c Ormdl1 Sgpl1 Sptssb Sgms2 Sptssa Sgms1 Fa2h Aldh3b1 Ppap2b Sphk1 Ppap2a Degs2 Sphk2 Osbp Kdsr Ppm1l Ormdl3 Csnk1g2 Cers4 Cers5 Cers6 Acer3 Prkd3 Acer1 Cers3 Sptlc2 Cers2 Acer2 Cers1 Vapa Prkd1 Degs1 Sptlc3 Sgpp2 Sptlc1 Sgpp1 Prkd2 PROLACTIN RECEPTOR SIGNALING%REACTOME%R-HSA-1170546.1 Prolactin receptor signaling Btrc Rbx1 Skp1a Jak2 Stat5b Stat5a Cul1 Prl Ghr Ptpn11 Prlr DEFECTIVE ABCC8 CAN CAUSE HYPOGLYCEMIAS AND HYPERGLYCEMIAS%REACTOME DATABASE ID RELEASE 59%5683177 Defective ABCC8 can cause hypoglycemias and hyperglycemias Kcnj11 Abcc8 PCP CE PATHWAY%REACTOME%R-HSA-4086400.2 PCP CE pathway Psmc6 Dvl1 Scrib Vangl2 Psmc5 Psmc2 Prkcg Dvl3 Psmd2 Ror1 Psmb9 Ror2 Psmf1 Psmb8 Prkcb Dvl2 Prkca Psme4 Arrb2 Pfn1 Rhoa Psmc1 Psmc4 Psmc3 Psme3 Wnt11 Wnt4 Rac1 Prickle1 Wnt5b Pard6a Wnt5a Ryk Wnt1 Cltb Ap2m1 Psmd12 Psma7 Psmd11 Daam1 Ap2a1 Psma5 Psmd14 Psmb5 Ap2a2 Psmb4 Rac3 Ubc Psmd13 Psma4 Psmd10 Psmb7 Psma3 Psma6 Psmb6 Psmb2 Psmb3 Psmb1 Psma2 Psma1 Ap2s1 Psmd9 Fzd6 Smurf1 Psmd1 Shfm1 Psme2 Clta Ap2b1 Psme1 Psmd3 Psmd4 Cltc Psmb10 Psmd6 Fzd2 Rac2 Psmd5 Fzd1 Fzd3 Psmd7 Fzd4 Smurf2 Fzd5 Fzd7 Fzd8 Psmb11 Psmd8 SIGNALING BY EGFR IN CANCER%REACTOME%R-HSA-1643713.1 Signaling by EGFR in Cancer Shc1 Egf Kras Nras Cdc37 Hsp90aa1 Plcg1 Pik3ca Hras Sos1 Ubc Egfr Gab1 Cbl Pik3r1 RNA POLYMERASE III TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 59%76046 RNA Polymerase III Transcription Initiation Brf2 Pou2f1 Zfp143 Polr2f Polr2e Polr2h Tbp Gtf3c1 Gtf3c6 Gtf3c3 Gtf3c2 Bdp1 Gtf3c4 Polr2k Crcp Polr3a Polr3gl Snapc2 Snapc1 Polr3k Snapc4 Polr3h Brf1 Polr3f Polr3g Snapc5 Gtf3c5 Polr1d Polr1c Polr3d Polr3e Snapc3 Polr3b Gtf3a Polr3c REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN%REACTOME%R-HSA-1234174.1 Regulation of Hypoxia-inducible Factor (HIF) by oxygen Psmc6 Psmc5 Psmc2 Psmd2 Psmb9 Psmf1 Psmb8 Psme4 Arnt Psmc1 Psmc4 Psmc3 Psme3 Hif1a Epas1 Hif3a Crebbp Car9 Ep300 Epo Ajuba Wtip Egln3 Hif1an Rbx1 Limd1 Psmd12 Psma7 Psmd11 Egln2 Psmd14 Psma5 Psmb5 Cul2 Ube2d3 Psmb4 Ubc Psmd13 Psmd10 Psma4 Psmb7 Psma3 Vegfa Psma6 Psmb6 Psmb2 Psmb3 Psmb1 Psma2 Psma1 Psmd9 Ube2d1 Cited2 Tceb1 Psmd1 Shfm1 Psme2 Psme1 Psmd3 Psmd4 Psmb10 Psmd6 Psmd5 Vhl Psmd7 Psmb11 Psmd8 CLEC7A (DECTIN-1) INDUCES NFAT ACTIVATION%REACTOME DATABASE ID RELEASE 59%5607763 CLEC7A (Dectin-1) induces NFAT activation Itpr1 Ppp3cb Ahcyl1 Ppp3ca Itpr3 Nfatc2 Ppp3r1 Nfatc1 Itpr2 Nfatc3 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA%REACTOME%R-HSA-3359454.1 Defective TCN2 causes hereditary megaloblastic anemia Tcn2 FORMATION OF HIV-1 ELONGATION COMPLEX CONTAINING HIV-1 TAT%REACTOME%R-HSA-167200.3 Formation of HIV-1 elongation complex containing HIV-1 Tat Gtf2h5 Gtf2h4 Cdk9 Gtf2h3 Ercc3 Ercc2 Polr2i Polr2f Polr2j Polr2e Nelfa Polr2h Nelfb Ell Polr2c Mnat1 Polr2d Supt4a Tcea1 Polr2b Tceb1 Tceb3 Supt16 Polr2k Polr2g Ccnt1 Ctdp1 Ssrp1 Ccnh Cdk7 Polr2a Nelfe Supt5 Nelfcd Gtf2h1 Gtf2f1 Ncbp1 Ncbp2 Gtf2h2 Gtf2f2 AMINO ACID AND DERIVATIVE METABOLISM%REACTOME%R-HSA-71291.3 Amino acid and derivative metabolism 2410127L17Rik Crym Qdpr Gstz1 Acat1 Phykpl Bcat2 Aass Hal Acad8 Bbox1 Il4i1 Hgd Ivd Aldh6a1 Aldh4a1 Ido2 Bckdk Rps27 Fah Bcat1 Hibadh Ido1 Pipox Auh Aldh9a1 Dbt Gnmt Tyrp1 Aanat Oaz3 Oaz2 Arg1 Paox Odc1 Srm Ckmt2 Ckmt1 Arg2 Gamt Ass1 Nags Oaz1 Nmral1 Tmlhe Slc6a8 Nqo1 Ppm1k Gatm Bckdha Sat1 Bckdhb Agmat Acadsb Azin2 Hibch Slc25a2 Azin1 Slc6a12 Cps1 Sms Otc Ckm Asl Ckb Txnrd1 Slc6a7 Slc6a11 Slc25a15 Gclm Ahcy Cndp2 Gclc Oca2 Gldc Slc3a2 Tyr Kmo Tdo2 Hnmt Afmid Acmsd Hdc Asrgl1 Ftcd Prodh Slc45a2 Uroc1 Slc7a5 Hpd Aldh7a1 Haao Carns1 Ccbl1 Pah Dct Pcbd1 Hykk Mat1a Lias Tat Gcdh Kynu Grhpr Got2 Amdhd1 Ddo Aadat Dao Slc25a21 Ccbl2 Psmf1 Psme4 Psme3 Ndufab1 Psma7 Psmb5 Psmb4 Mri1 Adi1 Got1 Psmb7 Enoph1 Bhmt2 Apip Psmb6 Mtap Dars Psmb2 Rars Psmb3 Eef1e1 Psmb1 Lars Aimp1 Iars Mars Aimp2 Eprs Slc5a5 Qars Kars Ddc Th Dbh Pnmt Dld Ogdh Psme2 Hsd17b10 Psme1 Mtrr Psmb10 Psmb11 Mtr Tshb Dlst Mccc2 Mccc1 Shmt1 Asns Tst Ado Cdo1 Cth Cbs Nnmt Ethe1 Suox Sqrdl Csad Gls2 Agxt2 Scly Tph2 Tph1 Gcsh Psmd12 Psmd11 Dhtkd1 Psmd14 Sepsecs Pstk Pycr2 Psmd13 Eefsec Pycr1 Psmd10 Oat Glud1 Pycrl Lipt2 Aspg Lipt1 Psat1 Naalad2 Agxt Phgdh Serinc5 Amt Secisbp2 Serinc4 Inmt Sars Aspa Serinc3 Psph Gpt Serinc1 Hao1 Serinc2 Gadl1 Glul Shfm1 Bhmt Rpl39 Psmc6 Tpo Rplp1 Psmc5 Duox2 Dio3 Slc25a10 Psmc2 Iyd Dio2 Rpl7 Psmd2 Rps21 Rplp2 Psmb9 Psmb8 Rps25 Cga Rpl4 Rps26 Rps27l Rpl18a Rpl34 Rpl32 Psmc1 Psmc4 Rpl26 Psmc3 Rpl24 Rps9 Rps7 Rps5 Gls Rpsa Rpl37 Rps4x Papss2 Papss1 Pdhb Dlat Gcat Pdhx Psma5 Pdha1 Psma4 Psma3 Psma6 Psma2 Psma1 Psmd9 Rpl22 Rpl10l Rpl23 Rpl39l Rpl13a Rpl22l1 Rps15a Psmd1 Rpl11 Rpl17 Rps3 Rpl19 Rpl18 Rps16 Rps14 Psmd3 Rps19 Psmd4 Rps18 Psmd6 Psmd5 Rps11 Rps10 Psmd7 Duox1 Psmd8 Dio1 GABA RECEPTOR ACTIVATION%REACTOME DATABASE ID RELEASE 59%977443 GABA receptor activation Gngt1 Adcy7 Gng7 Adcy6 Adcy5 Gng4 Adcy4 Adcy3 Adcy2 Gngt2 Adcy1 Gng10 Adcy9 Adcy8 Gnai2 Gnai1 Kcnj5 Kcnj9 Gnai3 Gnal Gabbr2 Gabbr1 Gng12 Gnb2 Gnb1 Gnb3 Gng8 Gng3 Gng2 Gabrr2 Gabrr3 Gabrb2 Gabrr1 Kcnj10 Gabrq Kcnj3 Gabra2 Kcnj16 Kcnj15 Gabra5 Gabra1 Gabra6 Gabra3 Gabra4 Kcnj6 Gabrg2 Gabrg3 Gnat3 Kcnj2 Arhgef9 Kcnj12 Kcnj4 Gabrb3 Gabrb1 2-LTR CIRCLE FORMATION%REACTOME%R-HSA-164843.1 2-LTR circle formation Lig4 Psip1 Xrcc5 Banf1 Xrcc6 Xrcc4 Hmga1 SIGNALING BY NOTCH2%REACTOME DATABASE ID RELEASE 59%1980145 Signaling by NOTCH2 Adam10 Maml3 Ubc Cntn1 Maml2 Aph1b Creb1 Maml1 Gzmb Psen2 Ncstn Mdk Notch2 Mib2 Neurl1a Neurl1b Mamld1 Fcer2a Ep300 Rbpj Hes5 Jag2 Mib1 Dll1 Dll4 Hes1 Jag1 VPR-MEDIATED INDUCTION OF APOPTOSIS BY MITOCHONDRIAL OUTER MEMBRANE PERMEABILIZATION%REACTOME%R-HSA-180897.2 Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization Slc25a5 Slc25a4 FGFR4 LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 59%190322 FGFR4 ligand binding and activation Fgf1 Fgf23 Fgf16 Fgf2 Fgf15 Fgf20 Klb Fgf18 Fgf9 Fgf6 Fgf4 Fgfr4 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX%REACTOME%R-HSA-72695.2 Formation of the ternary complex, and subsequently, the 43S complex Eif2s1 Eif2s2 Eif3i Eif3k Eif3l Eif3m Rps21 Rps27 Eif3a Eif3b Eif3c Rps25 Eif3d Rps26 Rps27l Eif3e Eif3f Eif3h Eif3g Rps9 Eif2s3x Rps7 Rps5 Eif1ax Eif3j2 Rps15a Rps3 Rps16 Rps14 Rps19 Rps18 Rps11 Rps10 Rpsa Rps4x INITIATION OF NUCLEAR ENVELOPE REFORMATION%REACTOME%R-HSA-2995383.1 Initiation of Nuclear Envelope Reformation Emd Ankle2 Ppp2r2a Ppp2ca Banf1 Vrk1 Lmnb1 Ppp2r1a Lemd3 Lemd2 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS%REACTOME%R-HSA-425366.1 Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds Slc22a6 Slc39a14 Cp Slc39a1 Slc22a3 Slc22a4 Slc22a5 Slc39a5 Slc39a4 Slc39a3 Slc39a2 Slc39a8 Slc39a6 Slc39a7 Slc22a8 Slc22a7 Slc2a13 Slc6a12 Slc6a7 Slc6a11 Slc41a2 Slc41a1 Slc40a1 Slc22a2 Rhag Slc22a1 Slc44a3 Slc44a4 Slc44a5 Rhcg Slc6a9 Slc5a7 Slc44a1 Slc6a5 Slc44a2 Slc6a6 Slc14a2 Slc18a1 Slc6a20a Slc14a1 Slc6a18 Slc6a19 Slc6a1 Slc6a2 Slc6a13 Slc6a15 Slc6a14 Rhbg Slc6a3 Slc30a1 Slc39a10 Slc30a2 Slc30a3 Slc2a6 Slc2a5 Slc2a12 Slc2a4 Slc2a3 Slc2a10 Slc2a2 Slc2a1 Slc2a8 Slc2a7 Slc13a3 Emb Slc13a1 Slc13a2 Slc22a12 Slc30a5 Slc30a8 Slc13a5 Slc22a16 Slc30a6 Slc22a15 Slc30a7 Slc16a3 Slc16a1 Bsg Slc22a18 Slc13a4 Slc16a8 Slc11a2 Slc10a6 Slc16a7 Slc47a1 Heph Slc5a2 Slc5a3 Slc5a1 2010001E11Rik Slc5a9 Slc5a4a Slc5a11 Fgf21 Slc2a9 Slc11a1 Slc31a1 Slc18a2 INFLUENZA INFECTION%REACTOME%R-HSA-168254.1 Influenza Infection Nup85 Nup160 Isg15 Rps27 Xpo1 Polr2i Polr2j Polr2c Polr2d Polr2b Polr2g Nup107 Polr2a Hspa1a Gtf2f1 Gtf2f2 Nup37 Calr Nup43 Nup133 Clta Ipo5 Grsf1 Cltc Ranbp2 Kpna3 Kpna4 Kpna7 Rpl39 Rplp1 Canx Rpl7 Nup50 Rps21 Tpr Rplp2 Hsp90aa1 Rps25 Rpl4 Ndc1 Rps26 Nup214 Rps27l Aaas Nup210 Rpl18a Nup188 Rpl34 Nup54 Rpl32 Nup35 Nupl2 Nup62 Rpl26 Nup205 Nup155 Rpl24 Nup88 Rps9 Pom121 Rps7 Rae1 Rps5 Polr2f Pabpn1 Polr2e Polr2h Nup93 Nup153 Polr2k Ran Rpsa Slc25a5 Rpl37 Rps4x Cpsf4 Dnajc3 Rpl22 Rpl10l Tgfb1 Rpl23 Rpl39l Rpl13a Rpl22l1 Kpnb1 Rps15a Rpl11 Rpl17 Rps3 Rpl19 Rpl18 Kpna1 Rps16 Rps14 Rps19 Rps18 Rps11 Rps10 Eif2ak2 DEGRADATION OF AXIN%REACTOME%R-HSA-4641257.2 Degradation of AXIN Psmc6 Psmc5 Psmc2 Psmd2 Psmb9 Psmb8 Psmf1 Psme4 Psmc1 Psmc4 Psmc3 Psme3 Axin1 Axin2 Psmd12 Rnf146 Psma7 Psmd11 Psmd14 Psma5 Psmb5 Psmb4 Psmd13 Ubc Psmd10 Psma4 Psma3 Psmb7 Psma6 Psmb6 Psmb2 Psmb3 Psma2 Psmb1 Psma1 Psmd9 Tnks Psmd1 Shfm1 Psme2 Psme1 Psmd3 Tnks2 Psmd4 Psmb10 Psmd6 Psmd5 Psmd7 Smurf2 Psmb11 Psmd8 TP53 REGULATES TRANSCRIPTION OF DEATH RECEPTORS AND LIGANDS%REACTOME%R-HSA-6803211.1 TP53 Regulates Transcription of Death Receptors and Ligands Fas Trp53bp2 Tnfrsf10b Trp53 Tmem219 Trp73 Trp63 Igfbp3 Ppp1r13b REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS%REACTOME DATABASE ID RELEASE 59%450531 Regulation of mRNA stability by proteins that bind AU-rich elements Psmc6 Prkcd Psmc5 Psmc2 Psmd2 Parn Psmb9 Xpo1 Psmf1 Psmb8 Prkca Psme4 Nup214 Psmc1 Psmc4 Psmc3 Psme3 Zfp36 Dcp1a Mapkapk2 Exosc9 Exosc8 Exosc7 Exosc5 Anp32a Exosc4 Dcp2 Hspa1a Zfp36l1 Dis3 Xrn1 Exosc3 Tnpo1 Exosc1 Exosc2 Ywhaz Hspb1 Hspa8 Psmd12 Tnfsf13 Psma7 Psmd11 Psmd14 Psma5 Psmb5 Psmb4 Ubc Psmd13 Psmd10 Psma4 Psmb7 Psma3 Psma6 Psmb6 Psmb2 Psmb3 Psmb1 Psma2 Psma1 Akt1 Psmd9 Ywhab Psmd1 Shfm1 Psme2 Psme1 Mapk11 Psmd3 Psmd4 Mapk14 Psmb10 Psmd6 Pabpc1 Psmd5 Elavl1 Eif4g1 Psmd7 Psmb11 Psmd8 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA%REACTOME DATABASE ID RELEASE 59%159227 Transport of the SLBP independent Mature mRNA Nup85 Nup160 Nup37 Nup50 Tpr Nup43 Nup133 Nxf1 Ndc1 Nup214 Aaas Nup210 Nup188 Nup54 Nup35 Nupl2 Nup62 Nup205 Nup155 Nup88 Pom121 Rae1 Nup93 Nup153 Eif4e Ranbp2 Nup107 Ncbp1 Ncbp2 Alyref SMAC-MEDIATED APOPTOTIC RESPONSE%REACTOME DATABASE ID RELEASE 59%111469 SMAC-mediated apoptotic response Casp3 Diablo Casp9 Casp7 Xiap SYNTHESIS OF PC%REACTOME%R-HSA-1483191.4 Synthesis of PC Mfsd2a Chkb Pemt Csnk2a2 Cept1 Chat Chka Phospho1 Slc44a3 Abhd3 Slc44a4 Lpcat1 Slc44a5 Pctp Lpin2 Slc44a1 Slc44a2 Bche Stard10 Csnk2b Ache Lpin3 Lpin1 Stard7 Chpt1 Pcyt1a Pcyt1b SIGNALING BY RETINOIC ACID%REACTOME DATABASE ID RELEASE 59%5362517 Signaling by Retinoic Acid Rara Rarb Pdhb Dlat Cyp26c1 Aldh8a1 Aldh1a3 Crabp1 Cyp26b1 Rdh5 Rdh13 Crabp2 Rdh14 Aldh1a2 Dhrs3 Rdh10 Dhrs4 Pdhx Akr1c18 Pdha1 Sdr16c5 Rxrg Rarg Pdk1 Pdk2 Rdh11 Pdk3 Pdk4 Rxrb Fabp5 Cyp26a1 Rxra Dld Adh1 Adh4 Dhrs9 Cpt1b BC089597 Cpt1a Ppard Aldh1a1 MITOTIC G1-G1 S PHASES%REACTOME%R-HSA-453279.1 Mitotic G1-G1 S phases Ppp2r1a Rb1 Mcm6 Cdkn2c Ccne1 Mcm3 Lin37 Mcm2 Lin54 Mcm5 Ccne2 Mcm4 Ccnd2 Hdac1 Cdkn1c Cdk6 Ptk6 Orc4 Orc5 Mcm8 Mcm7 Mnat1 Pole Cdt1 Fbxo5 Cdc45 Ccnd3 Orc2 Orc3 Orc6 Orc1 Prim1 Pole2 Rpa2 Rpa1 Ppp2r2a Rpa3 Pola1 Pola2 Pole4 Prim2 Pole3 Cdkn1a Psmd12 Psmd11 Psmd14 Psmd13 Psmd10 Ppp2r1b Shfm1 Psmc6 Psmc5 Psmc2 Psmd2 Dyrk1a Pcna Lin9 Psmb9 Psmf1 Psmb8 Rbl2 Rbl1 Mybl2 Cdc6 Cdk2 Cdk1 E2f5 Skp1a E2f4 E2f1 Psmc1 Rrm2 Ccna1 Psmc4 Rbbp4 Tyms Psmc3 Dhfr Skp2 Cdc25a Tk2 Ccna2 Cul1 Cdk4 Psme3 Tfdp2 Cks1b Lin52 Max Tfdp1 Ccnd1 Top2a E2f2 E2f3 Cdkn1b Ppp2cb Wee1 Ppp2ca Akt2 Akt3 Psma7 Psma5 Psmb5 Psmb4 Ubc Psma4 Psma3 Psmb7 Myc Psma6 Psmb6 Cdc7 Cdkn2a Psmb2 Psmb3 Psma2 Dbf4 Psmb1 Mcm10 Psma1 Cdkn2b Akt1 Psmd9 Psmd1 Psme2 Psme1 Psmd3 Psmd4 Ccnh Psmb10 Psmd6 Psmd5 Cdk7 Psmd7 Psmd8 RNA POLYMERASE II TRANSCRIPTION ELONGATION%REACTOME%R-HSA-75955.2 RNA Polymerase II Transcription Elongation Cdk9 Supt6 Polr2f Polr2i Polr2e Polr2j Polr2h Nelfa Nelfb Ell Mnat1 Polr2c Rtf1 Polr2d Supt4a Polr2b Mllt1 Mllt3 Aff4 Polr2g Polr2k Ctdp1 Ccnt1 Ssrp1 Wdr61 Polr2a Nelfe Supt5 Nelfcd Gtf2h1 Gtf2f1 Ncbp1 Ccnt2 Ncbp2 Gtf2h2 Gtf2f2 Gtf2h5 Paf1 Gtf2h4 Eaf1 Gtf2h3 Ercc3 Ctr9 Cdc73 Ercc2 Tcea1 Tceb1 Iws1 Tceb3 Supt16 Ccnh Ccnk Leo1 Cdk7 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION)%REACTOME%R-HSA-2173791.1 TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) Tgfb1 Arhgef18 F11r Smurf1 Cgn Pard3 Prkcz Ubc Tgfbr1 Fkbp1a Tgfbr2 Rhoa Pard6a FRS2-MEDIATED ACTIVATION%REACTOME%R-HSA-170968.1 Frs2-mediated activation Akap9 Ppp2r1a Csf2 Jak1 Frs2 Nras Frs3 Rasgrf1 Psmf1 Raf1 Psme4 Il5ra Fgf1 Il17rd Fgf2 Cnksr1 Csk Cnksr2 Erbb2 Fgf9 Ptk2 Fgf7 Psme3 Fgf6 Fgf4 Fgf3 Ppp5c Ranbp9 Ppp2cb Shc1 Lamtor2 Nrg2 Ppp2ca Shc3 Nrg1 Shc2 Psma7 Artn Nrtn Plcg1 Brap Psmb5 Psmb4 Ubc Nrg3 Psmb7 Nrg4 Psmb6 Psmb2 Psmb3 Psmb1 Mapk3 Mapk1 Ksr1 Ptpra Dusp16 Dusp10 Map3k11 Paqr3 Psme2 Psme1 Ncam1 Sos1 Braf Psmb10 Apbb1ip Rapgef1 Psmb11 Csf2rb2 Rapgef2 Csf2ra Actn2 Nf1 Pdgfrb Pdgfra Kbtbd7 Il2rg Arrb2 Egfr Arrb1 Ret Ntrk1 Vwf Sptan1 Pspn Map2k1 Rbx1 Crkl Fgg Map2k2 Cul3 Psmd12 Pdgfb Psmd11 Rasgef1a Psmd14 Rasa3 Rasa4 Psmd13 Psmd10 Il2 Rasa2 Rasa1 Nefl Spred3 Kit Spred2 Grin2a Spred1 Spta1 Il5 Ppp2r1b Sptbn4 Ywhab Kras Gdnf Shfm1 Irs2 Syngap1 Hbegf Irs1 Il3ra Btc Il2ra Il2rb Angpt1 Psmc6 Egf Fgf23 Psmc5 Fgf22 Mark3 Psmc2 Fgf20 Psmd2 Dab2ip Tek Psmb9 Psmb8 Araf Hras Grin1 Ppp2r5e Dlg4 Ppp2r5c Ppp2r5d Ppp2r5a Psmc1 Psmc4 Psmc3 Sptbn2 Itgb3 Sptbn1 Fyn Phb Grin2c Rasgrp4 Rasgrp3 Pebp1 Ppp2r5b Rasgrp1 Tln1 Fga Fgb Grin2d Grin2b Sptb Hgf Gfra2 Gfra3 Gfra4 Ereg Jak2 Pea15a Itga2b Rap1a Jak3 Wdr83 Camk2d Rap1b Camk2a Fgfr4 Camk2b Psma5 Rasal3 Rasal2 Psma4 Psma3 Psma6 Vcl Camk2g Psma2 Psma1 Gfra1 Psmd9 Ngf Dusp7 Iqgap1 Fgf16 Dusp6 Dusp9 Fgf15 Dusp8 Klb Fgf18 Psmd1 Met Fn1 Rasal1 Dusp1 Psmd3 Psmd4 Psmd6 Psmd5 Dusp2 Psmd7 Dusp5 Psmd8 Fgf10 Dusp4 ADENYLATE CYCLASE ACTIVATING PATHWAY%REACTOME%R-HSA-170660.1 Adenylate cyclase activating pathway Adcy7 Adcy6 Adcy5 Adcy4 Adcy3 Adcy2 Adcy1 Adcy9 Gnal Adcy8 ACTIVATION OF NF-KAPPAB IN B CELLS%REACTOME%R-HSA-1169091.1 Activation of NF-kappaB in B cells Psmc6 Psmc5 Psmc2 Psmd2 Psmb9 Psmb8 Psmf1 Prkcb Btrc Psme4 Malt1 Card11 Nfkb1 Fbxw11 Skp1a Psmc1 Psmc4 Psmc3 Cul1 Psme3 Map3k7 Bcl10 Rel Nfkbie Rela Nfkbia Nfkbib Chuk Psmd12 Psma7 Psmd11 Psmd14 Psma5 Psmb5 Psmb4 Psmd13 Ubc Psmd10 Psma4 Psmb7 Psma3 Psma6 Psmb6 Psmb2 Psmb3 Psmb1 Psma2 Psma1 Psmd9 Ikbkb Psmd1 Shfm1 Psme2 Psme1 Ikbkg Psmd3 Psmd4 Psmb10 Psmd6 Psmd5 Psmd7 Psmb11 Psmd8 IRON UPTAKE AND TRANSPORT%REACTOME DATABASE ID RELEASE 59%917937 Iron uptake and transport Heph Cybrd1 Lcn2 Hmox1 Cp Slc40a1 Hmox2 Slc46a1 Atp6v0d2 Atp6v0d1 Atp6v0b Atp6v1c2 Atp6v1c1 Mcoln1 Steap2 Atp6v0e Atp6ap1 Atp6v1g3 Atp6v1e2 Tfrc Fth1 Mfsd7b Atp6v1e1 Ftl1 Atp6v0e2 Atp6v1a Atp6v1b1 Tcirg1 Trf Atp6v1b2 Atp6v1g1 Atp6v1g2 Atp6v0a1 Atp6v0a2 Atp6v1h Atp6v0a4 Steap3 Atp6v1d Atp6v1f Slc22a17 Slc11a2 Abcg2 GSD IV%REACTOME%R-HSA-3878781.1 GSD IV Gys2 Gys1 Gyg CRMPS IN SEMA3A SIGNALING%REACTOME%R-HSA-399956.1 CRMPs in Sema3A signaling Fyn Nrp1 Gsk3b Crmp1 Plxna2 Dpysl2 Dpysl5 Dpysl3 Fes Plxna4 Plxna3 Cdk5 Cdk5r1 Plxna1 Sema3a Dpysl4 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION%REACTOME DATABASE ID RELEASE 59%399955 SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion Fyn Nrp1 Rac1 Rras Tln1 Rnd1 Plxna2 Fes Farp2 Plxna4 Plxna3 Plxna1 Pip5k1c Sema3a NGF-INDEPENDANT TRKA ACTIVATION%REACTOME%R-HSA-187024.1 NGF-independant TRKA activation Adcyap1r1 Adora2a Adcyap1 Ntrk1 Ntrk2 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS%REACTOME%R-HSA-442755.1 Activation of NMDA receptor upon glutamate binding and postsynaptic events Actn2 Adcy3 Camkk1 Gria2 Adcy1 Akap9 Prkacb Camk2d Rasgrf1 Gria3 Gria4 Camk2a Adcy8 Camk2b Hras Raf1 Grin1 Dlg4 Nefl Camk2g Grin2a Mapk1 Creb1 Rps6ka6 Rps6ka3 Grin2c Rps6ka2 Rps6ka1 Rras Camk4 Braf Pdpk1 Gria1 Grin2d Prkaca Grin2b STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES%REACTOME%R-HSA-1834941.2 STING mediated induction of host immune responses Prkdc Tmem173 Xrcc5 Tbk1 Ddx41 Xrcc6 Nlrp4e Stat6 Nlrc3 Dtx4 Irf3 Trex1 Mre11a Trim21 Mb21d1 CRNA SYNTHESIS%REACTOME%R-HSA-192869.2 cRNA Synthesis BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN%REACTOME%R-HSA-446193.1 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein St6galnac6 St6galnac5 St6galnac4 St6galnac3 St6gal2 Rft1 Uap1 Dpagt1 Nagk Fuk Alg11 Alg14 Neu1 Neu3 Neu2 Neu4 Gmppa Gmppb Dpm1 Cmas Dpm2 Nus1 Dpm3 Slc17a5 Gne Npl Amdhd2 Nans Mpdu1 Nanp Alg3 Alg6 Alg8 Alg9 Alg1 St6gal1 Alg2 Tsta3 Dolpp1 Dolk Dhdds St8sia3 Gmds Fuom St8sia2 St8sia6 Gfpt1 Renbp St3gal4 Mpi Ctsa Pgm3 St6galnac1 Srd5a3 St6galnac2 Fpgt Glb1 Gfpt2 St8sia1 Slc35a1 St3gal1 St3gal2 St8sia5 Slc35c1 Pmm2 Pmm1 St8sia4 Gnpnat1 Alg10b Mvd Nudt14 St3gal5 Alg5 St3gal6 HYALURONAN UPTAKE AND DEGRADATION%REACTOME%R-HSA-2160916.2 Hyaluronan uptake and degradation Hexa Hexb Hyal2 Chp1 Lyve1 Gusb Hmmr Slc9a1 Cd44 Hyal1 Stab2 Hyal3 MAPK3 (ERK1) ACTIVATION%REACTOME%R-HSA-110056.2 MAPK3 (ERK1) activation Il6ra Il6 Map2k1 Jak1 Cdk1 Jak2 Mapk3 Ptpn11 Tyk2 INHIBITION OF INTERFERON SYNTHESIS%REACTOME DATABASE ID RELEASE 59%168305 Inhibition of Interferon Synthesis CONDENSATION OF PROMETAPHASE CHROMOSOMES%REACTOME%R-HSA-2514853.2 Condensation of Prometaphase Chromosomes Ncaph Ccnb2 Cdk1 Csnk2a2 Smc4 Smc2 Csnk2b Ncapd2 DSCAM INTERACTIONS%REACTOME DATABASE ID RELEASE 59%376172 DSCAM interactions Dscam Mapk13 Mapk12 Mapk14 Rac1 Mapk8 Ntn1 Pak1 Dcc Dscaml1 Mapk11 DARPP-32 EVENTS%REACTOME DATABASE ID RELEASE 59%180024 DARPP-32 events Ppp2cb Ppp2r1b Ppp3cc Ppp1r1b Pde4d Ppp2ca Pde4c Ppp3cb Prkar2a Prkacb Ppp2r1a Ppp3ca Ppp3r1 Pde4a Pde4b Ppp1ca Prkar2b Prkar1a Ppp2r5d Prkar1b Prkaca Cdk5 SMALL INTERFERING RNA (SIRNA) BIOGENESIS%REACTOME DATABASE ID RELEASE 59%426486 Small interfering RNA (siRNA) biogenesis Ago2 Ago1 Tsnax Tarbp2 Ago4 Prkra Tsn Ago3 Dicer1 ACTIVATION OF TRKA RECEPTORS%REACTOME DATABASE ID RELEASE 59%187015 Activation of TRKA receptors Ngf Adcyap1r1 Adora2a Adcyap1 Ntrk1 Ntrk2 MAP3K8 (TPL2)-DEPENDENT MAPK1 3 ACTIVATION%REACTOME%R-HSA-5684264.2 MAP3K8 (TPL2)-dependent MAPK1 3 activation Map2k1 Chuk Ikbkb Map2k4 Ikbkg Map3k8 Btrc Ubc Nfkb1 Skp1a Fbxw11 Tnip2 Cul1 DERMATAN SULFATE BIOSYNTHESIS%REACTOME%R-HSA-2022923.1 Dermatan sulfate biosynthesis Dsel Chst14 Bgn Dcn Ust Bcan Ncan Dse Vcan Cspg4 Cspg5 SYNTHESIS OF ACTIVE UBIQUITIN: ROLES OF E1 AND E2 ENZYMES%REACTOME DATABASE ID RELEASE 59%8866652 Synthesis of active ubiquitin: roles of E1 and E2 enzymes Ube2b Ube2r2 Ube2q2 Usp9x Ube2t Ube2a Uba6 Ube2e3 Ubc Otulin Ube2d1 Ube2z Cdc34 Ube2w Ube2c Ube2g2 Ube2k Ube2e1 Ube2g1 Ube2h Usp5 Usp7 Uchl3 Ube2l3 Uba1 TYPE II NA+ PI COTRANSPORTERS%REACTOME DATABASE ID RELEASE 59%427589 Type II Na+ Pi cotransporters Slc34a2 Slc34a1 Slc34a3 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER%REACTOME%R-HSA-2691230.1 Signaling by NOTCH1 HD Domain Mutants in Cancer Mib2 Adam10 Neurl1a Neurl1b Ubc Notch1 Adam17 Jag2 Dll1 Mib1 Dll4 Jag1 ETHANOL OXIDATION%REACTOME%R-HSA-71384.2 Ethanol oxidation Acss1 Aldh2 Aldh1b1 Adh5 Acss2 Adh1 Adh7 Adh4 Aldh1a1 NEGATIVE REGULATION OF FGFR3 SIGNALING%REACTOME DATABASE ID RELEASE 59%5654732 Negative regulation of FGFR3 signaling Ppp2cb Spry2 Fgf23 Fgf16 Ppp2ca Fgf20 Frs2 Fgf18 Ppp2r1a Mknk1 Braf Fgf1 Ubc Cbl Fgf2 Fgf9 Mapk3 Ptpn11 Fgf4 Mapk1 GLYCOSPHINGOLIPID METABOLISM%REACTOME DATABASE ID RELEASE 59%1660662 Glycosphingolipid metabolism Psap Hexa Gm2a Enpp7 Ugcg B3galnt1 Asah2 Gba2 Asah1 Hexb Gltp Cerk Ugt8a Ctsa Neu1 Cptp B4galnt1 Esyt3 Neu3 Esyt1 Neu2 Esyt2 Smpd3 Sumf2 Sumf1 Galc Glb1 Arsg Arsi Arsb Arsa Gla Arsk Arsj Smpd4 Smpd1 Gba Smpd2 FORMATION OF TC-NER PRE-INCISION COMPLEX%REACTOME DATABASE ID RELEASE 59%6781823 Formation of TC-NER Pre-Incision Complex Gtf2h5 Gtf2h4 Rbx1 Ppie Ddb1 Ercc8 Prpf19 Zfp830 Ercc6 Gtf2h3 Ercc3 Ubc Ercc2 Polr2i Polr2f Polr2j Polr2e Polr2h Mnat1 Polr2c Polr2d Cops7b Cops7a Tcea1 Polr2b Isy1 Aqr Uvssa Polr2k Polr2g Cops8 Xpa Cul4a Cops6 Ccnh Cops2 Usp7 Cops4 Cops5 Ep300 Cops3 Cdk7 Polr2a Xab2 Gtf2h1 Cul4b Gtf2h2 TRANSCRIPTIONAL REGULATION BY THE AP-2 (TFAP2) FAMILY OF TRANSCRIPTION FACTORS%REACTOME%R-HSA-8864260.3 Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors Esr1 Atad2 Cdkn1a Yeats4 Wwox Pitx2 Cga Mybl2 Egfr Kdm5b Myc Vegfa Nop2 Erbb2 Kit Yy1 Apoe Dek Cited1 Tfap2b Cited2 Tfap2a Tgfa Tfap2d Tfap2c Npm1 Tfap2e Cited4 Hspd1 Crebbp Ep300 Kctd15 Ube2i Kctd1 ABACAVIR TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 59%2161517 Abacavir transmembrane transport Abcb1a Slc22a2 Slc22a1 Slc22a3 Abcg2 SUMO IS CONJUGATED TO E1 (UBA2:SAE1)%REACTOME%R-HSA-3065676.1 SUMO is conjugated to E1 (UBA2:SAE1) Sumo3 Sae1 Uba2 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC)%REACTOME%R-HSA-975956.1 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Rpl39 Rplp1 Etf1 Rpl7 Rps21 Rps27 Rplp2 Rps25 Rpl4 Rps26 Rps27l Rpl18a Rpl34 Rpl32 Upf1 Rpl26 Rpl24 Rps9 Rps7 Rps5 Rpl22 Gspt1 Rpl10l Rpl23 Rpl39l Gspt2 Rpl13a Rpl22l1 Rps15a Rpl11 Rpl17 Rps3 Rpl19 Rpl18 Rps16 Rps14 Rps19 Rps18 Pabpc1 Rps11 Eif4g1 Rps10 Rpsa Ncbp1 Rpl37 Ncbp2 Rps4x DEGRADATION OF CYSTEINE AND HOMOCYSTEINE%REACTOME DATABASE ID RELEASE 59%1614558 Degradation of cysteine and homocysteine Tst Ado Cdo1 Cth Ethe1 Suox Slc25a10 Sqrdl Csad MISCELLANEOUS DIGESTION EVENTS%REACTOME DATABASE ID RELEASE 59%8935690 Miscellaneous digestion events Guca2b Guca2a Alpi Gucy2c DEADENYLATION-DEPENDENT MRNA DECAY%REACTOME DATABASE ID RELEASE 59%429914 Deadenylation-dependent mRNA decay Hbs1l Cnot4 Cnot7 Cnot6 Cnot1 Parn Cnot3 Cnot2 Cnot8 Skiv2l Pan3 Pan2 Dcp1b Tnks1bp1 Dcp1a Exosc9 Edc4 Exosc8 Dcps Exosc7 Exosc5 Exosc4 Cnot11 Nt5c3b Cnot10 Rqcd1 Dcp2 Wdr61 Dis3 Xrn1 Exosc3 Exosc1 Exosc2 Lsm1 Lsm2 Lsm5 Cnot6l Lsm7 Lsm3 Eif4a3 Lsm4 Lsm6 Eif4b Ttc37 Edc3 Eif4a1 Eif4a2 Paip1 Eif4e Pabpc1 Eif4g1 Ddx6 Patl1 G PROTEIN GATED POTASSIUM CHANNELS%REACTOME DATABASE ID RELEASE 59%1296059 G protein gated Potassium channels Gngt1 Gng7 Gng4 Kcnj5 Kcnj9 Kcnj10 Gngt2 Kcnj3 Gng10 Kcnj16 Kcnj15 Gabbr2 Gabbr1 Kcnj2 Gng12 Kcnj12 Gnb2 Gnb1 Kcnj4 Gnb3 Gng8 Kcnj6 Gng3 Gng2 NICOTINAMIDE SALVAGING%REACTOME DATABASE ID RELEASE 59%197264 Nicotinamide salvaging Apoa1bp Parp8 Slc5a8 Parp14 Nampt Parp16 Parp6 Parp9 Parp10 Ptgis Parp4 Nnmt Ptgs2 Nudt12 Naprt Cyp8b1 Slc22a13 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION)%REACTOME%R-HSA-198725.1 Nuclear Events (kinase and transcription factor activation) Ppp2cb Ppp2r1b Dusp3 Creb1 Mapk7 Dusp7 Mapkapk2 Rps6ka3 Dusp6 Rps6ka2 Ppp2ca Rps6ka1 Ppp2r1a Mapk11 Mapk14 Ppp2r5d Vrk3 Mapk3 Elk1 Rps6ka5 Mef2c Mapk1 Mef2a Dusp4 KINESINS%REACTOME%R-HSA-983189.2 Kinesins Kif2c Kif2b Kif18a Kif12 Kif15 Kif19a Kif6 Kif1c Kif21a Kif3c Kif21b Kif3b Kif1b Kif3a Kif1a Kif2a Kif18b Kifc5b Klc1 Kif11 Kifc2 Kif16b Kif26a Kif5a Kif5b Klc3 Klc2 Klc4 Kif26b Kif13b Kif20b Kif4 Racgap1 Kif20a Kifap3 Kif22 Kif27 Kif23 Cenpe Kif9 TRNA MODIFICATION IN THE NUCLEUS AND CYTOSOL%REACTOME DATABASE ID RELEASE 59%6782315 tRNA modification in the nucleus and cytosol Trmt44 Trdmt1 Trp53rkb Tprkb Trmt112 Osgep Pus3 Adat2 Nsun6 Mettl1 Trmt10a Adat1 Pus7 Ftsj1 Trmt1 Nsun2 Qtrtd1 Trmt13 Trmt12 Trmt11 Tyw1 Alkbh8 Lcmt2 Eprs 6430573F11Rik Cdkal1 Qtrt1 Ctu2 Ctu1 Trit1 Trmt61a Thg1l Wdr4 Trmt5 Tyw3 Urm1 Tyw5 Dus2 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING%REACTOME%R-HSA-73779.2 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening Gtf2h5 Gtf2a1 Taf13 Gtf2h4 Taf11 Gtf2a2 Gtf2b Gtf2h3 Ercc3 Taf1 Taf2 Taf4b Taf7 Taf4a Taf12 Taf5 Taf6 Taf3 Ercc2 Polr2i Polr2f Polr2j Polr2e Gtf2e1 Polr2h Tbp Gtf2e2 Polr2c Mnat1 Polr2d Ak6 Polr2b Taf9b Taf9 Polr2k Polr2g Ccnh Cdk7 Polr2a Gtf2h1 Gtf2f1 Gtf2h2 Gtf2f2 RESOLUTION OF D-LOOP STRUCTURES THROUGH SYNTHESIS-DEPENDENT STRAND ANNEALING (SDSA)%REACTOME DATABASE ID RELEASE 59%5693554 Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Rad51 Nbn Rad51ap1 Dna2 Kat5 Rbbp8 Wrn Bard1 Palb2 Brca1 Blm Mre11a Xrcc3 Rad51d Atm Xrcc2 Rad50 Rad51b Top3a Rad51c Exo1 Rtel1 Brip1 Brca2 KERATAN SULFATE DEGRADATION%REACTOME%R-HSA-2022857.1 Keratan sulfate degradation Hexa Hexb Omd Prelp Kera Glb1 Lum Ogn Fmod Gns TRIF-MEDIATED PROGRAMMED CELL DEATH%REACTOME DATABASE ID RELEASE 59%2562578 TRIF-mediated programmed cell death Ticam2 Casp8 Ripk3 Fadd Ripk1 Ticam1 Tlr4 Tlr3 Ly96 Cd14 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI%REACTOME%R-HSA-975576.1 N-glycan antennae elongation in the medial trans-Golgi Mgat5 St8sia3 Chst8 St8sia2 St8sia6 Cga B4galt3 Chst10 Lhb Mgat4a B4galt1 Mgat4b B4galt5 St3gal4 B4galt4 B4galt6 B4galt2 Mgat3 Man2a1 Fut8 Mgat2 St6gal1 Fuca1 Mgat4c NEPHRIN INTERACTIONS%REACTOME%R-HSA-373753.1 Nephrin interactions Fyn Iqgap1 Actn2 Actn1 Kirrel2 Kirrel3 Sptan1 Pik3ca Cd2ap Nck2 Actn4 Actn3 Cask Wasl Pik3r1 Pik3cb Nck1 Pik3r2 Sptbn1 Magi2 TRANSPORT OF CONNEXONS TO THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 59%190872 Transport of connexons to the plasma membrane Gjb2 Gja1 LIGAND-GATED ION CHANNEL TRANSPORT%REACTOME%R-HSA-975298.1 Ligand-gated ion channel transport Gabrr2 Gabrr3 Glrb Gabrb2 Gabrr1 Gabrq Gabra2 Htr3a Htr3b Gabra5 Gabra1 Gabra6 Arhgef9 Glra1 Gabra3 Gabra4 Glra4 Gabrg2 Glra3 Gabrg3 Gabrb3 Glra2 Gabrb1 WNT5A-DEPENDENT INTERNALIZATION OF FZD4%REACTOME%R-HSA-5099900.1 WNT5A-dependent internalization of FZD4 Ap2m1 Prkcg Clta Ap2b1 Prkcb Ap2a1 Dvl2 Prkca Ap2a2 Arrb2 Cltc Fzd4 Wnt5a Ap2s1 Cltb CELLULAR RESPONSE TO HYPOXIA%REACTOME%R-HSA-2262749.1 Cellular response to hypoxia Psmc6 Psmc5 Psmc2 Psmd2 Psmb9 Psmf1 Psmb8 Psme4 Arnt Psmc1 Psmc4 Psmc3 Psme3 Hif1a Epas1 Hif3a Crebbp Car9 Ep300 Epo Ajuba Wtip Egln3 Hif1an Rbx1 Limd1 Psmd12 Psma7 Psmd11 Egln2 Psmd14 Psma5 Psmb5 Cul2 Ube2d3 Psmb4 Ubc Psmd13 Psmd10 Psma4 Psmb7 Psma3 Vegfa Psma6 Psmb6 Psmb2 Psmb3 Psmb1 Psma2 Psma1 Psmd9 Ube2d1 Cited2 Tceb1 Psmd1 Shfm1 Psme2 Psme1 Psmd3 Psmd4 Psmb10 Psmd6 Psmd5 Vhl Psmd7 Psmb11 Psmd8 MRNA DECAY BY 5' TO 3' EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 59%430039 mRNA decay by 5' to 3' exoribonuclease Lsm1 Lsm2 Dcp1a Edc4 Lsm5 Lsm7 Lsm3 Lsm4 Lsm6 Ddx6 Dcp2 Patl1 Edc3 Dcp1b Xrn1 TACHYKININ RECEPTORS BIND TACHYKININS%REACTOME%R-HSA-380095.2 Tachykinin receptors bind tachykinins Tacr2 Tacr3 Tac2 Tacr1 Tac1 IRAK4 DEFICIENCY (TLR5)%REACTOME%R-HSA-5603037.1 IRAK4 deficiency (TLR5) Irak4 Myd88 Tlr5 INTERLEUKIN RECEPTOR SHC SIGNALING%REACTOME%R-HSA-912526.3 Interleukin receptor SHC signaling Akap9 Ppp2r1a Csf2 Jak1 Frs2 Nras Frs3 Rasgrf1 Psmf1 Raf1 Psme4 Il5ra Fgf1 Il17rd Fgf2 Cnksr1 Csk Cnksr2 Erbb2 Fgf9 Ptk2 Fgf7 Psme3 Fgf6 Fgf4 Fgf3 Ppp5c Ranbp9 Ppp2cb Shc1 Lamtor2 Nrg2 Ppp2ca Shc3 Nrg1 Shc2 Psma7 Artn Nrtn Brap Gab2 Psmb5 Psmb4 Ubc Nrg3 Psmb7 Nrg4 Psmb6 Psmb2 Psmb3 Psmb1 Mapk3 Mapk1 Ksr1 Ptpra Dusp16 Dusp10 Map3k11 Paqr3 Psme2 Psme1 Ncam1 Sos1 Braf Psmb10 Apbb1ip Psmb11 Csf2rb2 Rapgef2 Csf2ra Actn2 Nf1 Pdgfrb Pdgfra Kbtbd7 Il2rg Arrb2 Egfr Arrb1 Ret Vwf Sptan1 Pspn Map2k1 Rbx1 Fgg Map2k2 Cul3 Psmd12 Pdgfb Psmd11 Rasgef1a Psmd14 Rasa3 Rasa4 Psmd13 Inppl1 Psmd10 Il2 Rasa2 Rasa1 Nefl Spred3 Kit Spred2 Grin2a Spred1 Spta1 Il5 Ppp2r1b Sptbn4 Ywhab Kras Gdnf Shfm1 Irs2 Syngap1 Hbegf Ptpn6 Irs1 Il3ra Btc Il2ra Il2rb Angpt1 Psmc6 Egf Fgf23 Psmc5 Fgf22 Mark3 Psmc2 Fgf20 Psmd2 Dab2ip Tek Psmb9 Psmb8 Araf Hras Grin1 Ppp2r5e Dlg4 Ppp2r5c Ppp2r5d Ppp2r5a Psmc1 Psmc4 Psmc3 Pik3cb Sptbn2 Pik3cd Sptbn1 Itgb3 Fyn Phb Grin2c Rasgrp4 Rasgrp3 Inpp5d Pebp1 Ppp2r5b Rasgrp1 Tln1 Pik3ca Fga Fgb Grin2d Grin2b Sptb Hgf Gfra2 Gfra3 Gfra4 Ereg Jak2 Pea15a Itga2b Rap1a Jak3 Wdr83 Camk2d Rap1b Camk2a Fgfr4 Camk2b Psma5 Rasal3 Rasal2 Psma4 Psma3 Psma6 Vcl Camk2g Psma2 Psma1 Gfra1 Psmd9 Dusp7 Iqgap1 Fgf16 Dusp6 Dusp9 Fgf15 Dusp8 Klb Fgf18 Psmd1 Met Fn1 Rasal1 Dusp1 Psmd3 Psmd4 Psmd6 Psmd5 Dusp2 Pik3r3 Psmd7 Pik3r1 Dusp5 Psmd8 Fgf10 Pik3r2 Dusp4 G ALPHA (I) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 59%418594 G alpha (i) signalling events Oprk1 Rxfp4 Rxfp3 Ptger3 Saa3 Cxcl2 Cxcl9 Cxcl5 Grm7 Grm8 App Grm2 Grm3 Grm4 Hc Mchr1 Hebp1 Ccl5 Cxcr1 Fpr1 Ccr1 Agt Oprl1 Anxa1 Cxcr2 Cxcr3 Nmur1 Nmur2 Cxcl3 Cxcl1 Ccl20 Ccr2 Cxcr6 Ccr5 Cxcl10 Cxcr4 Cxcr5 Apln Gnat1 Gnat2 Gnat3 Hrh3 Pyy Hrh4 Hcar1 Aplnr Hcar2 Oprm1 Adcy7 Adcy6 Rgs18 Adcy5 Adcy4 Rgs14 Adcy3 Adcy2 Rgs19 Adcy1 Gal Adcy9 Gnaz Rgs10 Pf4 Adcy8 Rgs12 Rgs11 Htr5a Rgs21 Npy1r Rgs22 Gpsm1 Rgs20 Rgs16 Rho Rgs13 Rgr Sucnr1 Npy5r Npy4r Pnoc Gabbr2 Gabbr1 Npy2r Casr Ptgdr2 Opn1sw Adora3 Adora1 C5ar1 Penk Lpar5 Oxgr1 Mtnr1a P2ry13 P2ry12 P2ry14 Mtnr1b Ccr9 Ccr8 Ccr7 Adra2a Ccr6 Ccr4 Adra2c Ccr3 Adra2b Ccr10 Bdkrb1 Bdkrb2 Kng2 Rgsl1 Ppbp Insl5 Tas2r118 Tas2r126 Tas2r121 Tas2r120 Tas2r119 Gper1 Tas2r108 Ccl25 Ccl28 Galr2 Agtr2 Tas2r107 Rrh Htr1d Pmch Htr1f Rln3 Gpr18 Galr1 Fpr3 Pomc Gpr17 Fpr2 Htr1b Htr1a Rgs4 Drd4 Rgs5 Rgs7 Drd2 Rgs6 Drd3 Rgs9 Rgs8 C3ar1 Opn1mw Gpr55 Rgs1 P2ry4 Gngt1 Gng7 Gng4 Gngt2 Tas2r137 Tas2r136 Tas2r135 Sst Gng10 Ackr3 Tas2r131 Tas2r130 Tas2r138 Tas2r139 Nmu Chrm2 Nms Chrm4 Tas2r140 Tas2r144 Gnai2 Gnai1 S1pr5 Gnai3 S1pr2 S1pr3 S1pr1 S1pr4 Sstr2 Sstr1 Opn3 Gng11 Gng13 Sstr5 Gng12 Npbwr1 Gnb2 Sstr3 Gnb1 Sstr4 Gnb3 Ppy Gnb5 Cort Opn5 Gnb4 Npb Npy Gng8 Npw Gng3 Gng2 C3 Lpar3 Lpar1 Lpar2 Gcat Oprd1 Pdyn Cxcl16 Cxcl13 Cxcl12 Cxcl11 Cnr2 Cnr1 TRAFFICKING OF MYRISTOYLATED PROTEINS TO THE CILIUM%REACTOME DATABASE ID RELEASE 59%5624138 Trafficking of myristoylated proteins to the cilium Arl3 Unc119b Nphp3 Cys1 Rp2h TOLL LIKE RECEPTOR 4 (TLR4) CASCADE%REACTOME DATABASE ID RELEASE 59%166016 Toll Like Receptor 4 (TLR4) Cascade Tbk1 Ppp2r1a Btrc Mapk9 Ikbke Nfkb2 Tank Nfkb1 Traf3 Ecsit Fbxw11 Saa3 Mapkapk3 Tnip2 Myd88 Nod2 Nod1 Dhx9 S100b Mapk10 Sigirr Map3k7 Irak3 Peli1 Irak2 Mapkapk2 Irak1 App Tab1 Map2k6 Tab2 Tab3 Mapk8 Jun Map3k1 Ripk2 Map2k7 Ager Map2k3 Map2k4 Map3k8 Rela Nfkbia Peli3 Nfkbib Irak4 Peli2 Casp8 Fadd Map2k1 Ripk1 Cd180 Tlr2 Tlr6 Ly86 Ptpn4 Itgb2 Socs1 Bpi Itgam Dnm2 Rps6ka5 Dnm1 Ppp2r1b Ticam2 Ube2d1 Ripk3 Birc3 Rps6ka3 Birc2 Rps6ka2 Ticam1 Rps6ka1 Traf6 Ikbkb Ube2v1 Tlr4 Ube2n Tlr3 Ly96 Cd14 Ikbkg Cd36 Dnm3 Tlr1 Tirap Ptpn11 Irf7 Irf3 Skp1a Ppp2r5d Cul1 Vrk3 Elk1 Mef2c Mef2a Dusp3 Mapk7 Creb1 Plcg2 Lbp Atf2 Fos Ppp2cb Chuk Ppp2ca Btk Ube2d3 Ubc Mapk3 Mapk1 Dusp7 Dusp6 Mapk11 Mapk14 Dusp4 SIGNALING BY FGFR2 AMPLIFICATION MUTANTS%REACTOME%R-HSA-2023837.1 Signaling by FGFR2 amplification mutants Fgfr2 INTRINSIC PATHWAY OF FIBRIN CLOT FORMATION%REACTOME%R-HSA-140837.2 Intrinsic Pathway of Fibrin Clot Formation Kng2 Gp1bb F10 C1qbp Gp1ba F12 F11 Serping1 Prcp Serpine2 F8 Gp5 Gp9 Serpina5 Proc Klkb1 A2m Serpind1 Serpinc1 Vwf F2 F9 RETROGRADE NEUROTROPHIN SIGNALLING%REACTOME%R-HSA-177504.1 Retrograde neurotrophin signalling Ngf Ap2m1 Clta Ap2b1 Ap2a1 Ap2a2 Cltc Dnm3 Sh3gl2 Ntrk1 Dnm2 Dnal4 Ap2s1 Dnm1 ARMS-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 59%170984 ARMS-mediated activation Akap9 Ppp2r1a Csf2 Jak1 Frs2 Nras Frs3 Rasgrf1 Psmf1 Raf1 Psme4 Il5ra Fgf1 Il17rd Fgf2 Cnksr1 Csk Cnksr2 Erbb2 Fgf9 Ptk2 Fgf7 Psme3 Fgf6 Fgf4 Fgf3 Ppp5c Ranbp9 Ppp2cb Shc1 Lamtor2 Nrg2 Ppp2ca Shc3 Nrg1 Shc2 Psma7 Artn Nrtn Brap Psmb5 Psmb4 Ubc Nrg3 Psmb7 Nrg4 Psmb6 Psmb2 Psmb3 Psmb1 Mapk3 Mapk1 Ksr1 Ptpra Dusp16 Dusp10 Map3k11 Paqr3 Psme2 Psme1 Ncam1 Sos1 Braf Psmb10 Apbb1ip Psmb11 Csf2rb2 Rapgef2 Csf2ra Actn2 Nf1 Pdgfrb Pdgfra Kbtbd7 Il2rg Arrb2 Egfr Arrb1 Ret Ntrk1 Vwf Sptan1 Pspn Map2k1 Rbx1 Fgg Map2k2 Cul3 Psmd12 Pdgfb Psmd11 Rasgef1a Psmd14 Rasa3 Rasa4 Psmd13 Psmd10 Il2 Rasa2 Rasa1 Nefl Spred3 Kit Spred2 Grin2a Spred1 Spta1 Il5 Ppp2r1b Sptbn4 Ywhab Kras Gdnf Shfm1 Irs2 Syngap1 Hbegf Irs1 Il3ra Btc Il2ra Il2rb Angpt1 Psmc6 Egf Fgf23 Psmc5 Fgf22 Mark3 Psmc2 Fgf20 Psmd2 Dab2ip Tek Psmb9 Psmb8 Araf Hras Grin1 Ppp2r5e Dlg4 Ppp2r5c Ppp2r5d Ppp2r5a Psmc1 Psmc4 Psmc3 Sptbn2 Itgb3 Sptbn1 Fyn Phb Grin2c Rasgrp4 Rasgrp3 Pebp1 Ppp2r5b Rasgrp1 Tln1 Fga Fgb Grin2d Grin2b Sptb Hgf Gfra2 Gfra3 Gfra4 Ereg Jak2 Pea15a Itga2b Rap1a Jak3 Wdr83 Camk2d Rap1b Camk2a Fgfr4 Camk2b Psma5 Rasal3 Rasal2 Psma4 Psma3 Psma6 Vcl Camk2g Psma2 Psma1 Gfra1 Psmd9 Ngf Dusp7 Iqgap1 Fgf16 Dusp6 Dusp9 Fgf15 Dusp8 Klb Fgf18 Psmd1 Met Kidins220 Fn1 Rasal1 Dusp1 Psmd3 Psmd4 Psmd6 Psmd5 Dusp2 Psmd7 Crk Dusp5 Psmd8 Fgf10 Dusp4 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 59%425374 Amino acid and oligopeptide SLC transporters Slc7a10 Slc5a8 Slc1a5 Slc1a3 Slc1a4 Slc25a10 Slc1a2 Slc7a11 Slc38a1 Slc1a7 Slc1a6 Slc38a2 Slc1a1 Slc32a1 Slc15a3 Slc38a5 Slc38a4 Slc38a3 Slc7a6 Slc3a2 Slc17a1 Slc5a5 Slc43a1 Slc7a1 Slc7a3 Slc15a2 Slc25a22 Slc15a1 Slc7a9 Slc3a1 Slc7a8 Slc43a2 Slc6a6 Slc7a7 Slc6a20a Slc17a5 Slc17a6 Slc6a18 Slc6a19 Slc25a18 Slc17a8 Slc7a5 Slc6a15 Slc6a14 Slc15a4 Slc6a12 Slc36a1 Slc36a2 MET INTERACTS WITH TNS PROTEINS%REACTOME DATABASE ID RELEASE 59%8875513 MET interacts with TNS proteins Itgb1 Tns4 Tns3 Met Hgf ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1%REACTOME DATABASE ID RELEASE 59%418592 ADP signalling through P2Y purinoceptor 1 Gngt1 P2ry1 Gng7 Gng4 Gngt2 Gng10 Gng11 Gng13 Gng12 Gnb2 Mapk14 Gnb1 Gnb3 Gnb5 Gnb4 Gna11 Pla2g4a Gng8 Gnaq Gna15 Gng3 Gng2 Gna14 INSULIN RECEPTOR SIGNALLING CASCADE%REACTOME DATABASE ID RELEASE 59%74751 Insulin receptor signalling cascade Pik3c3 Prkaa2 Akap9 Ppp2r1a Pik3r4 Prkaa1 Csf2 Jak1 Tsc1 Prkag2 Prkag1 Prkag3 Frs2 Nras Frs3 Rasgrf1 Psmf1 Raf1 Psme4 Il5ra Fgf1 Il17rd Fgf2 Cnksr1 Csk Cnksr2 Erbb2 Fgf9 Ptk2 Fgf7 Psme3 Fgf6 Fgf4 Fgf3 Ppp5c Ranbp9 Lamtor1 Ppp2cb Shc1 Lamtor2 Ppm1a Nrg2 Tlr9 Ppp2ca Shc3 Lamtor5 Nrg1 Akt2 Shc2 Psma7 Artn Nrtn Lamtor4 Brap Psmb5 Psmb4 Ubc Nrg3 Psmb7 Nrg4 Psmb6 Psmb2 Psmb3 Psmb1 Prkab1 Mapk3 Akt1 Mapk1 Ksr1 Ptpra Dusp16 Dusp10 Stk11 Map3k11 Prkab2 Paqr3 Psme2 Psme1 Ncam1 Sos1 Braf Psmb10 Apbb1ip Psmb11 Csf2rb2 Rapgef2 Csf2ra Actn2 Nf1 Tsc2 Pdgfrb Pdgfra Mlst8 Kbtbd7 Il2rg Arrb2 Egfr Gab1 Arrb1 Mtor Ret Vwf Rptor Ins2 Sptan1 Pspn Pde3b Map2k1 Rbx1 Fgg Map2k2 Cul3 Rragd Psmd12 Rragb Pdgfb Rragc Psmd11 Rraga Rasgef1a Eif4b Psmd14 Rasa3 Rasa4 Psmd13 Psmd10 Il2 Rasa2 Rasa1 Nefl Spred3 Kit Spred2 Grin2a Spred1 Spta1 Il5 Sptbn4 Ppp2r1b Ywhab Kras Insr Gdnf Shfm1 Cab39 Eif4e Strada Irs2 Stradb Cab39l Syngap1 Eef2k Hbegf Eif4g1 Irs1 Eif4ebp1 Il3ra Btc Il2ra Il2rb Angpt1 Ptpn11 Trib3 Psmc6 Egf Fgf23 Psmc5 Fgf22 Mark3 Psmc2 Fgf20 Psmd2 Dab2ip Tek Psmb9 Psmb8 Araf Hras Grin1 Grb10 Ppp2r5e Dlg4 Ppp2r5c Ppp2r5d Ppp2r5a Psmc1 Psmc4 Psmc3 Pik3cb Sptbn2 Sptbn1 Itgb3 Fyn Phb Grin2c Rasgrp4 Rasgrp3 Pebp1 Ppp2r5b Rasgrp1 Tln1 Pik3ca Fga Fgb Grin2d Grin2b Sptb Hgf Gfra2 Gfra3 Gfra4 Ereg Jak2 Pea15a Itga2b Rap1a Jak3 Wdr83 Camk2d Rap1b Camk2a Fgfr4 Camk2b Psma5 Rasal3 Rasal2 Psma4 Psma3 Psma6 Akt1s1 Vcl Camk2g Psma2 Psma1 Gfra1 Psmd9 Dusp7 Iqgap1 Fgf16 Dusp6 Dusp9 Fgf15 Dusp8 Klb Fgf18 Them4 Psmd1 Met Fn1 Rasal1 Dusp1 Psmd3 Psmd4 Pdpk1 Psmd6 Psmd5 Dusp2 Psmd7 Pik3r1 Dusp5 Psmd8 Fgf10 Pik3r2 Dusp4 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2%REACTOME DATABASE ID RELEASE 59%5140745 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 Ap2m1 Ror1 Clta Ror2 Ap2b1 Ap2a1 Ap2a2 Cltc Fzd2 Fzd5 Wnt5a Ap2s1 Cltb REPRODUCTION%REACTOME DATABASE ID RELEASE 59%1474165 Reproduction Izumo4 Zp3 Izumo2 Kcnu1 Izumo1 Hvcn1 Catsperg1 Catsperd Catsper1 Catsper2 Catsper3 Catsperb Catsper4 Hyal5 Acr B4galt1 Adam2 Ovgp1 Cd9 Adam30 Adam21 Zp1 Zp2 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 59%450341 Activation of the AP-1 family of transcription factors Mapk9 Mapk14 Jun Fos Mapk8 Mapk3 Mapk10 Mapk1 Atf2 Mapk11 CARGO TRAFFICKING TO THE PERICILIARY MEMBRANE%REACTOME DATABASE ID RELEASE 59%5620920 Cargo trafficking to the periciliary membrane Cct5 Tcp1 Cct8 Cct4 Rab3ip Rab8a Mkks Rho Cys1 Arf4 Bbs12 Pde6d Bbs10 Arl3 Arl6 Rab11a Smo Bbs7 Bbs9 Nphp3 Bbs5 Bbs4 Bbs2 Bbs1 Inpp5e Pkd1 Sstr3 Pkd2 Unc119b Cnga4 Mchr1 Asap1 Lztfl1 Ttc8 Cnga2 Rab11fip3 Arl13b Exoc3 Exoc4 Exoc1 Exoc5 Exoc6 Exoc8 Exoc7 Exoc2 Rp2h Gbf1 Cct2 Cct3 INHIBITION OF ADENYLATE CYCLASE PATHWAY%REACTOME DATABASE ID RELEASE 59%997269 Inhibition of adenylate cyclase pathway Gnai2 Adcy7 Gnai1 Adcy6 Adcy5 Adcy4 Adcy3 Gnai3 Adcy2 Adcy1 Gnat3 Adcy9 Gnal Adcy8 MRNA SPLICING%REACTOME DATABASE ID RELEASE 59%72172 mRNA Splicing Cwc22 Cwc27 Fus Cwc25 Cwc15 Hnrnpd Hnrnpc Ppie Ppih Gcfc2 Prpf4 Prpf3 Ppwd1 Wbp4 Usp39 Prpf40a Hnrnpu Hnrnpr Hnrnpa2b1 Hnrnpl Hnrnpm Hnrnpf Zcrb1 Dhx9 Hnrnpk Ppil1 Polr2i Polr2j Prcc Polr2c Polr2d Polr2b Dhx16 Dhx15 Polr2g Srrt Snrpn Rnpc3 Srrm2 Plrg1 Snrpc Prpf8 Gpkow Snrpa Prpf6 Polr2a Xab2 Gtf2f1 Ncbp1 Snrpa1 Ncbp2 Gtf2f2 Lsm2 Lsm5 Smndc1 Ccar1 Lsm7 Lsm3 Lsm4 Srsf10 Hspa8 Lsm8 Prpf31 Lsm6 Snrnp200 Prpf19 Ptbp1 Wbp11 Zrsr2 Rbm5 Snrpb2 Ctnnbl1 Snrpd2 Snrpd1 Sart1 Hnrnpul1 Snrpb Sf1 Snrpd3 Txnl4a Cdc5l Hnrnph1 Syf2 Hnrnph2 Pdcd7 Rbmx Aqr Zmat5 U2surp Eftud2 Ddx5 Phf5a Sugp1 Puf60 Rbm22 Tra2b Ddx46 Rbm17 Hnrnpa3 Ddx42 Polr2f Polr2e Pabpn1 Polr2h Dnajc8 Srsf2 Srsf3 Isy1 Prpf38a Polr2k Slu7 Srsf11 Magoh Cpsf1 Cstf1 Dhx38 Clp1 Ddx23 Srsf7 Hnrnpa1 Srsf9 Hnrnpa0 Alyref Srsf6 Nudt21 Cstf2t Sf3b4 Sf3b3 Fip1l1 Sf3b2 Rbm8a Cstf3 Casc3 Sympk Eif4a3 U2af1l4 Srsf1 Cstf2 Cpsf3 Cpsf2 Pqbp1 Cpsf4 Sf3b6 Cpsf7 Sf3b5 Crnkl1 Bcas2 Sf3a1 Sf3a2 Upf3b Sf3b1 Sf3a3 Papola Wdr33 Rnps1 Magohb Cdc40 Srrm1 Snrnp70 Ybx1 Tfip11 Snrnp27 Cherp Snrnp25 Snrnp35 Elavl2 Skiv2l2 Elavl1 Pcbp1 Pcbp2 Cd2bp2 Snrnp48 Snrnp40 PROCESSING OF INTRONLESS PRE-MRNAS%REACTOME%R-HSA-77595.2 Processing of Intronless Pre-mRNAs Nudt21 Pabpn1 Cstf2t Fip1l1 Cstf3 Sympk Cstf2 Cpsf3 Cpsf2 Cpsf4 Cpsf7 Cpsf1 Cstf1 Clp1 Papola Wdr33 Ncbp1 Ncbp2 BINDING AND ENTRY OF HIV VIRION%REACTOME%R-HSA-173107.1 Binding and entry of HIV virion Cd4 Ccr5 Cxcr4 Ppia UPTAKE AND ACTIONS OF BACTERIAL TOXINS%REACTOME DATABASE ID RELEASE 59%5339562 Uptake and actions of bacterial toxins Map2k1 Sv2c Eef2 Pdzd3 Vamp1 Sv2b Map2k2 Pdcd6ip Map2k7 Map2k4 Hsp90aa1 Snap25 Gucy2c Furin Hbegf Syt2 Hsp90ab1 Syt1 Sv2a Vamp2 Stx1b Cd9 Txnrd1 Stx1a SEROTONIN RECEPTORS%REACTOME DATABASE ID RELEASE 59%390666 Serotonin receptors Htr7 Htr1d Htr5a Htr6 Htr4 Htr1f Htr2a Htr1b Htr2b Htr2c Htr1a SYNTHESIS OF HEPOXILINS (HX) AND TRIOXILINS (TRX)%REACTOME DATABASE ID RELEASE 59%2142696 Synthesis of Hepoxilins (HX) and Trioxilins (TrX) Alox12 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX%REACTOME DATABASE ID RELEASE 59%204174 Regulation of pyruvate dehydrogenase (PDH) complex Pdhb Dlat Pdpr Rxra Dld Pdp2 Pdp1 Pdhx Pdha1 Pdk1 Pdk2 Ppard Pdk3 Pdk4 REGULATION OF DNA REPLICATION%REACTOME DATABASE ID RELEASE 59%69304 Regulation of DNA replication Psmc6 Psmc5 Psmc2 Psmd2 Psmb9 Psmf1 Psmb8 Rb1 Psme4 Mcm6 Cdc6 Cdk2 Mcm3 Mcm2 Mcm5 Mcm4 E2f1 Psmc1 Ccna1 Psmc4 Psmc3 Ccna2 Psme3 Fzr1 Gmnn Orc4 Orc5 Mcm8 E2f2 Mcm7 Cdt1 E2f3 Orc2 Orc3 Orc6 Orc1 Cdkn1b Cdkn1a Psmd12 Psma7 Psmd11 Psmd14 Psma5 Psmb5 Psmb4 Ubc Psmd13 Psmd10 Psma4 Psmb7 Psma3 Psma6 Psmb6 Psmb2 Psmb3 Psmb1 Psma2 Mcm10 Psma1 Psmd9 Psmd1 Shfm1 Psme2 Psme1 Psmd3 Psmd4 Psmb10 Psmd6 Psmd5 Psmd7 Psmb11 Psmd8 EPHA-MEDIATED GROWTH CONE COLLAPSE%REACTOME%R-HSA-3928663.1 EPHA-mediated growth cone collapse Efna2 Hsp90aa1 Efna1 Efna3 Yes1 Shb Lyn Myl6 Myh11 Rhoa Ptk2 Myh14 Kdr Myh10 Fyn Efna4 Efna5 Ngef Epha1 Myl12b Epha3 Myl12a Epha2 Epha6 Epha7 Epha8 Epha4 Epha5 Myh9 Rock1 Rock2 INTERLEUKIN-7 SIGNALING%REACTOME%R-HSA-1266695.4 Interleukin-7 signaling Jak1 Brwd1 Stat5b Jak3 Stat5a Hist1h3d Smarca4 Il7r Il2rg Hist2h3c1 Rag2 Il7 Rag1 Pik3r3 Pik3r1 Pik3r2 Hgf WNT LIGAND SECRETION IS ABROGATED BY THE PORCN INHIBITOR LGK974%REACTOME%R-HSA-5340573.1 WNT ligand secretion is abrogated by the PORCN inhibitor LGK974 Porcn CONSTITUTIVE SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%R-HSA-2660826.1 Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Adam10 Notch1 Adam17 Jag2 Dll1 Dll4 Jag1 MAJOR PATHWAY OF RRNA PROCESSING IN THE NUCLEOLUS AND CYTOSOL%REACTOME%R-HSA-6791226.3 Major pathway of rRNA processing in the nucleolus and cytosol Bysl Rpp21 Rpp25 Rrp36 Rps27 Pdcd11 Riok2 Riok1 Krr1 Pwp2 Riok3 Heatr1 Pno1 Pelp1 Utp18 Exosc9 Exosc8 Utp11l Mphosph10 Exosc7 Utp15 Exosc5 Exosc4 Diexf Pes1 Dcaf13 Cirh1a Nop56 Utp14a Tex10 Nol9 Nol6 Utp3 Eri1 Exosc3 Utp6 Exosc1 Nop58 Exosc2 Isg20l2 Xrn2 Bms1 Mphosph6 Ltv1 Utp20 Dhx37 Wdr75 Bop1 Nop14 Nob1 Tbl3 Tsr1 Fbl Wdr3 Wdr12 Senp3 Wdr18 Wdr43 Wdr46 Emg1 Rpl39 Rplp1 Ddx52 Rpl7 Rps21 Noc4l Rplp2 Las1l Ddx49 Rps25 Ddx47 Rpl4 Rps26 Rps27l Rpl18a Rpl34 Rpl32 C1d Rpl26 Rpl24 Rps9 Rps7 Rps5 Imp4 Imp3 Nol11 Csnk1d Csnk1e Rrp9 Rpsa Rpl37 Rps4x Exosc10 Rpp14 Rcl1 Rpl22 Rpp30 Rpp38 Rpl10l Rpl23 Rpl39l Rpl13a Rpl22l1 Rps15a Rpl11 Rpl17 Rps3 Rpl19 Rpl18 Rpp40 Rps16 Rps14 Rps19 Rps18 Skiv2l2 Rps11 Rps10 THE ACTIVATION OF ARYLSULFATASES%REACTOME%R-HSA-1663150.1 The activation of arylsulfatases Arsk Sumf2 Arsj Sumf1 Arsg Arsi Arsb Arsa ACTIVATION OF PUMA AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%R-HSA-139915.4 Activation of PUMA and translocation to mitochondria Trp53bp2 Trp53 E2f1 Trp73 Trp63 Ppp1r13b Tfdp2 Tfdp1 CELL CYCLE%REACTOME%R-HSA-1640170.1 Cell Cycle Nhp2 Prkcb Rfc5 Mcm6 Gins1 Rfc3 Mcm3 Mcm2 Mcm5 Mcm4 Rfc2 Gins4 Nipbl Rfc4 Gins2 Mau2 Rfc1 H2afj Gins3 H2afb2 Orc4 Orc5 Mcm8 Mcm7 Pole Cdt1 Cdc45 Dna2 Pold1 Pold2 Pold3 Pold4 Orc2 Orc3 Orc6 Orc1 Prim1 Pole2 Rpa2 Rpa1 Hist2h2be Rpa3 Pola1 Hspa2 Pola2 Hist2h2ac Lig1 Fen1 H3f3b Pole4 H3f3a Prim2 Pole3 Hist1h2bg Hist1h2bh Csnk2a2 Hist1h2bp Hist1h2bm Hist1h2bj Hist1h2bb Hist1h3d Csnk2b Hist1h2ak Fkbp6 Hist1h2ag Hist1h2ah Dkc1 Nup50 Pias4 Tpr Ndc1 Nup214 Hist2h3c1 Aaas Ppp1r12a Nup210 Nup188 Skp1a Nup54 Nup35 Rrm2 Nupl2 Nup62 Tyms Dhfr Nup205 Nup155 Cul1 Tk2 Nek6 Nup88 Nek7 Pom121 Nek9 Rae1 Tubg2 Gmnn Optn Numa1 E2f2 Ccnb2 Nup93 Phlda1 Gtse1 Cdc25b Nup153 Pkmyt1 E2f3 Cdk11b Tubgcp5 Tubgcp4 Tubgcp3 Tubgcp2 Hmmr Ajuba Foxm1 Fbxl7 Fkbpl Fbxl18 Bora Prkca Ccne1 Mdm4 Lin37 Lin54 Ccne2 Hdac1 Mnat1 Atrip Bard1 Chek2 Mre11a Rbx1 Cdkn1a Tpx2 Psmd12 Psmd11 Psmd14 Rad1 Psmd13 Setd8 Psmd10 Cdc23 Ppp2r1b Ube2d1 Ywhab Cdc27 Cdc14a Cdc16 Cdc20 Ube2c Kat5 Anapc16 Ube2e1 Anapc7 Anapc4 Shfm1 Anapc5 Anapc1 Anapc2 Mdm2 Psmc6 Pafah1b1 Psmc5 Ccp110 Nek2 Psmc2 Cep57 Psmd2 Haus7 Haus8 Ywhag Psmb9 Psmb8 Hsp90aa1 Ywhaq Rab8a B9d2 Prkar2b Ppp2r5e Haus3 Haus4 Cdk1 Ppp2r5c Cetn2 Ppp2r5d Ppp2r5a Ofd1 Psmc1 Psmc4 Haus2 Psmc3 Cep63 Anapc15 Alms1 Haus5 Anapc11 Haus6 Anapc10 Haus1 Fzr1 Tubb4a Tubb4b Clasp1 Ssna1 Tubg1 Csnk1d Cep250 Tuba4a Dynll1 Ppp2r5b Csnk1e Cep135 Cdk5rap2 Mapre1 Pcnt Sfi1 Cep70 Nedd1 Cdkn1b Actr1a Hist3h2ba Cep131 Pcm1 Prkaca Mlh1 Dync1i2 Fgfr1op Cep76 Cep78 Cep72 Dctn2 Chek1 Dctn3 Wee1 Ckap5 Ywhaz Cep164 Cdc25c Ywhah Tubb5 Tuba1a Sfn Cep41 Plk1 Cenpj Dync1h1 Psma5 Plk4 Blm Sdccag8 Psma4 Ppp1cb Psma3 Psma6 Hus1 Cdc7 H2afz Mdc1 Psma2 Dbf4 H2afx Mcm10 Psma1 Exo1 Brip1 Psmd9 Hist2h2aa1 Wrn Psmd1 Brca1 Psmd3 Psmd4 Ccnh Psmd6 Psmd5 Psmd7 Psmd8 Zw10 Ska1 Ankle2 Nup85 Pmf1 Nup160 Vrk1 Akap9 Spc25 Nudc Rps27 Ppp2r1a Ywhae Spc24 Xpo1 Clasp2 Itgb3bp Ninl Nuf2 Cep152 Trex1 Btrc Fbxw11 Cenpf Ppp1cc Cenpq Cenpp Ahctf1 Nbn Fbxo5 Cenpm Cenpl Cenpo Clip1 Npm1 Cenpn Aurkb Zwilch Cdca8 Aurka Cenpt Apitd1 Stag2 Sgol2b Ercc6l Stag1 Atm Ppp2r2a Banf1 Dsn1 Ep300 Nup107 Mad1l1 Pttg1 Smc1a Ube2i Rad21 Cenph Rad17 Cenpi Cenpe Cenpk Kif2c Tinf2 Pot1a Taok1 Birc5 Wrap53 Kif2b Tert Mis18bp1 Kif18a Bub1b Cenpw Terf1 Zwint Nup37 Terf2 Incenp Rbbp8 Wapal Acd Nup43 Ruvbl2 Ruvbl1 Nup133 Stra13 Rcc2 Mis18a Nsl1 Kif2a Oip5 Rbbp7 Ndel1 Rsf1 Spdl1 Ndc80 Emd Kntc1 Bub3 Cdca5 Bub1 Cenpu Mad2l1 Terf2ip Casc5 Smc3 Cenpa Espl1 Lemd3 Lemd2 Cenpc1 Psmc3ip Dmc1 Mlh3 Sgol1 Pds5a Ranbp2 Mis12 Pds5b Smarca5 Fam175a Dyrk1a Pcna Lin9 Clspn Psmf1 Rnf168 Psme4 Rbl2 Ube2v2 Rbl1 Mybl2 Cdc6 Spo11 Cdk2 Mnd1 Tex15 E2f5 Brcc3 Msh5 E2f4 Msh4 E2f1 Trp53bp1 Rad50 Ccna1 Rbbp4 Skp2 Uimc1 Cdc25a Ccna2 Psme3 Tfdp2 Cdk4 Lin52 Cks1b Babam1 Tfdp1 Max Top2a Ccnd1 Top3a Brca2 Ppp2cb Ppp2ca Akt2 Akt3 Psma7 Topbp1 Psmb5 Rad9a Psmb4 Ubc Rad9b Psmb7 Myc Pcbp4 Psmb6 Psmb2 Cdkn2a Psmb3 Psmb1 Cdkn2b Akt1 Zfp385a Mapk1 Herc2 Rad51 Bre Trp53 Psme2 Whsc1 Psme1 Hist1h3h Psmb10 Cdk7 Psmb11 Lmnb1 Rb1 Rab2a Cdkn2c Ncaph Arpp19 Mastl Ppp2r2d Mcph1 Ccnd2 Gorasp2 Cdkn1c Ensa Esco2 Esco1 Blzf1 Cdk6 Ptk6 Rab1 Smc4 Ncaph2 Ccnd3 Smc2 Ncapg2 Ncapd2 Ncapd3 Sec13 Gorasp1 Ctdnep1 Cnep1r1 Syne1 Syce3 Syce2 Syne2 Syce1 Ube2n Rfwd2 Rab1b Kif20a Smc1b Uso1 Hsp90ab1 Sun1 Sycp3 Stag3 Rec8 Sycp2 Sycp1 Kif23 Sun2 Tex12 Golga2 Rad51c Lpin2 Lpin3 Lpin1 Prdm9 RNA POLYMERASE III CHAIN ELONGATION%REACTOME%R-HSA-73780.2 RNA Polymerase III Chain Elongation Polr2f Polr2e Polr2h Polr2k Crcp Polr3a Polr3gl Polr3k Polr3h Polr3f Polr3g Polr1d Polr1c Polr3d Polr3e Polr3b Polr3c DUAL INCISION IN TC-NER%REACTOME%R-HSA-6782135.1 Dual incision in TC-NER Ppie Pcna Ddb1 Ercc6 Polk Rfc5 Rfc3 Rfc2 Rfc4 Rfc1 Polr2f Polr2i Polr2e Polr2j Polr2h Pole Mnat1 Polr2c Polr2d Polr2b Pold1 Isy1 Pold2 Pold3 Pold4 Polr2g Polr2k Pole2 Xpa Rpa2 Ercc5 Cul4a Rpa1 Usp7 Ep300 Rpa3 Polr2a Xab2 Ercc4 Gtf2h1 Pole4 Ercc1 Cul4b Gtf2h2 Pole3 Gtf2h5 Gtf2h4 Rbx1 Ercc8 Prpf19 Zfp830 Gtf2h3 Ercc3 Ubc Ercc2 Tcea1 Aqr Uvssa Ccnh Cdk7 SUMOYLATION OF DNA DAMAGE RESPONSE AND REPAIR PROTEINS%REACTOME DATABASE ID RELEASE 59%3108214 SUMOylation of DNA damage response and repair proteins Nup85 Nup160 Nup50 Pias4 Tpr Rnf168 Ndc1 Nup214 Aaas Nup210 Nup188 Cetn2 Nup54 Nup35 Nupl2 Nup62 Rnf2 Nup205 Nsmce4a Nup155 Nup88 Pom121 Rae1 Nsmce2 Ring1 Nup93 Nsmce1 Sumo3 Nup153 Ndnl2 Stag2 Rpa1 Pias1 Stag1 Nup107 Xpc Hdac7 Smc1a Rad21 Ube2i Pml Nup37 Nup43 Nup133 Smc5 Parp1 Blm Smc6 Cdkn2a Mdc1 Smc3 Rad52 Herc2 Phc3 Wrn Phc2 Phc1 Brca1 Pcgf2 Cbx4 Cbx8 Cbx2 Ranbp2 Bmi1 Xrcc4 REGULATION OF IGF ACTIVITY BY IGFBP%REACTOME%R-HSA-381426.1 Regulation of IGF Activity by IGFBP Mmp1a Gzmf Igf2 Igf1 Ctsg Klk13 Igfbp2 Igfbp1 Plg Igfbp5 Igfbp4 Mmp2 Pappa2 Igfbp3 Pappa Igfals Igfbp6 F2 INTESTINAL INFECTIOUS DISEASES%REACTOME%R-HSA-8942233.1 Intestinal infectious diseases Pdzd3 Gucy2c RHO GTPASES ACTIVATE WASPS AND WAVES%REACTOME%R-HSA-5663213.1 RHO GTPases Activate WASPs and WAVEs Actg1 Actb Btk Wipf3 Wipf2 Nckap1l Wipf1 Wasf2 Baiap2 Ptk2 Wasf3 Nck1 Arpc5 Brk1 Mapk3 Arpc4 Abi1 Mapk1 Wasf1 Abi2 Actr2 Arpc1a Actr3 Arpc1b Rac1 Nckipsd Nckap1 Wasl Was Arpc3 Abl1 Arpc2 Cyfip1 Cyfip2 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1%REACTOME DATABASE ID RELEASE 59%174178 APC C:Cdh1 mediated degradation of Cdc20 and other APC C:Cdh1 targeted proteins in late mitosis early G1 Psmc6 Psmc5 Psmc2 Psmd2 Psmb9 Psmf1 Psmb8 Psme4 Psmc1 Psmc4 Skp2 Psmc3 Anapc15 Psme3 Anapc11 Anapc10 Fzr1 Aurkb Aurka Pttg1 Psmd12 Plk1 Psma7 Psmd11 Psmd14 Psma5 Psmb5 Psmb4 Ubc Psmd13 Psmd10 Psma4 Psmb7 Psma3 Psma6 Psmb6 Psmb2 Psmb3 Psmb1 Psma2 Psma1 Cdc23 Psmd9 Ube2d1 Cdc27 Cdc16 Cdc20 Ube2c Anapc16 Ube2e1 Psmd1 Anapc7 Shfm1 Psme2 Anapc4 Anapc5 Psme1 Anapc1 Anapc2 Psmd3 Psmd4 Psmb10 Psmd6 Psmd5 Psmd7 Psmb11 Psmd8 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1%REACTOME DATABASE ID RELEASE 59%113501 Inhibition of replication initiation of damaged DNA by RB1 E2F1 Ppp2cb Ppp2r1b Prim1 Ppp2ca E2f1 Pola1 Pola2 Ppp2r1a Tfdp2 Prim2 Tfdp1 Rb1 REGULATION OF TP53 DEGRADATION%REACTOME%R-HSA-6804757.1 Regulation of TP53 Degradation Ppp2cb Ppp2ca Akt2 Akt3 Sgk1 Ppp2r1a Mlst8 Rffl Mdm4 Mapkap1 Ubc Cdk1 Ccng1 Ppp2r5c Cdk2 Usp2 Mtor Cdkn2a Ccna1 Rnf34 Ccna2 Akt1 Ppp2r1b Trp53 Chek2 Rictor Mdm2 Pdpk1 Usp7 Atm Daxx Prr5 COENZYME A BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 59%196783 Coenzyme A biosynthesis Pank4 Coasy Ppcdc Pank1 Pank3 Pank2 Slc25a16 Ppcs ALPHA-DEFENSINS%REACTOME DATABASE ID RELEASE 59%1462054 Alpha-defensins Cd4 Prss2 Art1 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE%REACTOME%R-HSA-4641262.3 Disassembly of the destruction complex and recruitment of AXIN to the membrane Ppp2cb Dvl1 Apc Axin1 Ppp2ca Amer1 Csnk1a1 Ctnnb1 Dvl3 Ppp2r1a Dvl2 Ppp2r5e Ppp2r5c Ppp2r5d Ppp2r5a Ppp2r1b Frat2 Gsk3b Ppp2r5b Cav1 Csnk1g2 Wnt3a Fzd2 Fzd1 Wnt8a Wnt8b Fzd5 Lrp6 Wnt1 Lrp5 INSULIN EFFECTS INCREASED SYNTHESIS OF XYLULOSE-5-PHOSPHATE%REACTOME DATABASE ID RELEASE 59%163754 Insulin effects increased synthesis of Xylulose-5-Phosphate Tkt Taldo1 RETINOID CYCLE DISEASE EVENTS%REACTOME%R-HSA-2453864.2 Retinoid cycle disease events Rbp1 Napepld Opn1sw Rbp4 Opn1mw Rlbp1 Stra6 Ttr CARGO RECOGNITION FOR CLATHRIN-MEDIATED ENDOCYTOSIS%REACTOME%R-HSA-8856825.2 Cargo recognition for clathrin-mediated endocytosis Egf Ldlr Slc18a3 Dvl2 Arrb2 Chrm2 Egfr Arrb1 Adrbk1 Slc2a8 Dab2 Necap2 Snap91 Syt11 Sh3kbp1 Syt9 Reps1 Sgip1 Fcho2 Fcho1 Syt2 Reps2 Adrb2 Sh3gl1 Stam Hgs Wnt5a Agtr1a Stam2 Ston2 Apob Eps15 Cltb Vamp8 D130043K22Rik Ap2m1 Vamp3 Necap1 Tor1b Tor1a Cftr Picalm M6pr Ap2a1 Igf2r Ap2a2 Ubc Epn2 Cbl Scarb2 Syt8 Aak1 Sh3gl2 Agfg1 Ubqln2 Ubqln1 Tacr1 Vamp4 Ap2s1 Tfrc Cops7b Itsn2 Cops7a Trf Clta Ap2b1 Nedd8 Cops8 Cd3d Cops6 Cltc Cops2 Avp Cops4 Cops5 Avpr2 Cd4 Eps15l1 Cops3 Epn1 Syt1 Vamp7 Fzd4 Lrp2 Vamp2 Itsn1 Adrbk2 Cd3g Ldlrap1 HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME%R-HSA-5693579.1 Homologous DNA Pairing and Strand Exchange Chek1 Rbbp8 Topbp1 Trex1 Rfc5 Rad9a Blm Rfc3 Rad1 Rad9b Hus1 Rfc2 Rad50 Rad51b Rad51c Rfc4 Exo1 Brip1 Rad51 Nbn Rad51ap1 Atrip Dna2 Kat5 Wrn Bard1 Brca1 Palb2 Rpa2 Mre11a Rpa1 Xrcc3 Atm Rad51d Xrcc2 Rpa3 Top3a Rad17 Brca2 BETA-CATENIN INDEPENDENT WNT SIGNALING%REACTOME%R-HSA-3858494.3 Beta-catenin independent WNT signaling Scrib Dvl1 Vangl2 Nlk Prkcg Dvl3 Ror1 Ror2 Prkcb Prkca Dvl2 Arrb2 Pfn1 Rhoa Wnt11 Map3k7 Wnt4 Ppp3cb Rac1 Ppp3ca Ppp3r1 Nfatc1 Pde6a Pde6b Prickle1 Prkg1 Wnt5b Pard6a Wnt5a Wnt1 Ryk Cltb Pde6g Ap2m1 Ctnnb1 Psmd12 Daam1 Psmd11 Ap2a1 Psmd14 Ap2a2 Psmd13 Psmd10 Ap2s1 Tcf7l1 Ago2 Ago1 Tnrc6c Fzd6 Lef1 Tcf7 Gnat2 Tnrc6b Clta Shfm1 Ap2b1 Tnrc6a Ago4 Ago3 Itpr1 Cltc Fzd2 Rac2 Fzd1 Fzd3 Fzd4 Fzd7 Fzd5 Fzd8 Itpr3 Tcf7l2 Itpr2 Gngt1 Psmc6 Gng7 Gng4 Psmc5 Gngt2 Psmc2 Psmd2 Gng10 Psmb9 Psmf1 Psmb8 Psme4 Psmc1 Psmc4 Psmc3 Psme3 Prkg2 Gng11 Gng13 Gng12 Gnb2 Gnb1 Gnb3 Gnb5 Gnb4 Gng8 Gng3 Gng2 Psma7 Plcb1 Plcb2 Camk2a Psma5 Psmb5 Psmb4 Ubc Rac3 Psma4 Psma3 Psmb7 Psma6 Psmb6 Psmb2 Psmb3 Psma2 Psmb1 Psma1 Psmd9 Smurf1 Psmd1 Psme2 Gnao1 Psme1 Psmd3 Psmd4 Plcb3 Psmb10 Psmd6 Psmd5 Psmd7 Smurf2 Psmb11 Psmd8 Mov10 GLUCAGON SIGNALING IN METABOLIC REGULATION%REACTOME DATABASE ID RELEASE 59%163359 Glucagon signaling in metabolic regulation Adcy7 Adcy6 Gng7 Adcy5 Adcy4 Gng4 Adcy3 Gcg Adcy2 Prkar2a Adcy1 Gng10 Prkacb Gcgr Adcy9 Adcy8 Prkar2b Gng11 Gng13 Gng12 Gnb2 Gnb1 Gnb3 Prkar1a Prkar1b Gnb4 Prkaca Gng8 Gng3 Gng2 REGULATION OF RAS BY GAPS%REACTOME%R-HSA-5658442.1 Regulation of RAS by GAPs Psmc6 Psmc5 Nf1 Psmc2 Psmd2 Nras Dab2ip Psmb9 Psmf1 Psmb8 Kbtbd7 Hras Psme4 Psmc1 Psmc4 Psmc3 Psme3 Rbx1 Cul3 Psmd12 Psma7 Psmd11 Psmd14 Psma5 Psmb5 Rasa3 Rasal3 Psmb4 Rasa4 Ubc Psmd13 Rasal2 Psmd10 Psma4 Psmb7 Psma3 Rasa2 Psma6 Psmb6 Rasa1 Psmb2 Psmb3 Spred3 Psmb1 Psma2 Spred2 Psma1 Spred1 Psmd9 Kras Psmd1 Shfm1 Psme2 Psme1 Rasal1 Psmd3 Psmd4 Psmb10 Syngap1 Psmd6 Psmd5 Psmd7 Psmb11 Psmd8 UPTAKE AND FUNCTION OF ANTHRAX TOXINS%REACTOME%R-HSA-5210891.1 Uptake and function of anthrax toxins Furin Map2k1 Map2k2 Pdcd6ip Map2k7 Map2k4 CONSTITUTIVE SIGNALING BY ABERRANT PI3K IN CANCER%REACTOME DATABASE ID RELEASE 59%2219530 Constitutive Signaling by Aberrant PI3K in Cancer Egf Fgf23 Fgf22 Fgf20 Pdgfrb Frs2 Pdgfra Vav1 Fgf1 Egfr Gab1 Fgf2 Erbb2 Fgf9 Pik3cb Fgf7 Fgf6 Pik3cd Fgf4 Fgf3 Fyn Pik3ca Hgf Cd86 Ereg Nrg2 Nrg1 Pdgfb Cd80 Fgfr4 Nrg3 Nrg4 Kit Cd19 Fgf16 Fgf15 Klb Pik3ap1 Fgf18 Met Trat1 Irs2 Lck Hbegf Pik3r3 Irs1 Btc Pik3r1 Ptpn11 Fgf10 Pik3r2 RNA POLYMERASE I PROMOTER CLEARANCE%REACTOME%R-HSA-73854.2 RNA Polymerase I Promoter Clearance Mbd2 Ercc6 Hist2h3c1 Polr1a Znrd1 Polr1e Hdac1 Rbbp4 Chd3 Chd4 H2afj H2afb2 Polr2f Polr2e Polr2h Hdac2 Tbp Mnat1 Ubtf Polr1b Mbd3 Polr2k Hist2h2be Hist3h2ba Polr1d Polr1c Mta1 Hist2h2ac Ttf1 Gtf2h1 Kat2b Kat2a H3f3b Mta3 H3f3a Gtf2h2 Hist1h2bg Gtf2h5 Hist1h2bh Gtf2h4 Cd3eap Hist1h2bp Hist1h2bm Hist1h2bj Rbbp7 Hist1h2bb Gtf2h3 Ercc3 Mta2 H2afz Taf1d Taf1c H2afx Taf1b Mapk3 Taf1a Ercc2 Hist2h2aa1 Gatad2a Rrn3 Gatad2b Hist1h3d Ehmt2 Ccnh Hist1h2ak Hist1h2ag Cdk7 Hist1h2ah CLASS C 3 (METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS)%REACTOME DATABASE ID RELEASE 59%420499 Class C 3 (Metabotropic glutamate pheromone receptors) Tas2r137 Tas2r136 Tas2r118 Tas2r126 Tas2r135 Tas2r121 Tas2r131 Tas2r120 Tas2r130 Tas2r138 Tas2r139 Grm1 Gprc6a Grm5 Tas2r119 Tas2r140 Tas2r144 Grm7 Tas2r108 Grm8 Grm2 Grm3 Grm4 Tas2r107 Gabbr2 Gabbr1 Casr Tas1r3 Tas1r2 Tas1r1 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE%REACTOME%R-HSA-76042.2 RNA Polymerase II Transcription Initiation And Promoter Clearance Gtf2h5 Gtf2a1 Taf13 Gtf2h4 Taf11 Gtf2a2 Gtf2b Gtf2h3 Ercc3 Taf1 Taf2 Taf4b Taf7 Taf4a Taf12 Taf5 Taf6 Taf3 Ercc2 Polr2i Polr2f Polr2j Polr2e Gtf2e1 Polr2h Tbp Gtf2e2 Polr2c Mnat1 Polr2d Ak6 Polr2b Taf9b Taf9 Polr2k Polr2g Ccnh Cdk7 Polr2a Gtf2h1 Gtf2f1 Gtf2h2 Gtf2f2 PHASE 0 - RAPID DEPOLARISATION%REACTOME%R-HSA-5576892.1 Phase 0 - rapid depolarisation Scn2a1 Scn5a Cacng8 Cacng6 Cacng4 Scn9a Cacng1 Cacng3 Cacng5 Cacng2 Cacng7 Camk2d Camk2a Camk2b Scn2b Cacna1s Camk2g Scn10a Cacna1f Scn3a Scn3b Cacnb2 Cacnb3 Scn11a Cacna2d2 Cacna1c Fgf14 Cacna1d Fgf13 Fgf11 Fgf12 Cacna2d1 Cacna2d4 Cacna2d3 Scn7a Scn1a Cacnb4 Scn1b Scn8a Cacnb1 Scn4b Scn4a POU5F1 (OCT4), SOX2, NANOG REPRESS GENES RELATED TO DIFFERENTIATION%REACTOME%R-HSA-2892245.1 POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation Pou5f1 Sox2 CATION-COUPLED CHLORIDE COTRANSPORTERS%REACTOME DATABASE ID RELEASE 59%426117 Cation-coupled Chloride cotransporters Slc12a1 Slc12a2 Slc12a3 Slc12a4 Slc12a6 Slc12a5 Slc12a7 COOPERATION OF PDCL (PHLP1) AND TRIC CCT IN G-PROTEIN BETA FOLDING%REACTOME%R-HSA-6814122.2 Cooperation of PDCL (PhLP1) and TRiC CCT in G-protein beta folding Gngt1 Cct5 Gng7 Tcp1 Cct8 Gng4 Cct4 Csnk2a2 Gngt2 Cct7 Gng10 Gnaz Rgs11 Gnai2 Cct2 Cct6b Gnai1 Cct3 Rgs7 Rgs6 Gnai3 Rgs9 Gnat1 Gnat2 Pdcl Gnat3 Gnao1 Csnk2b Gng11 Gng13 Gng12 Gnb2 Gnb1 Gnb3 Gnb5 Gnb4 Gng8 Gng3 Gng2 SYNTHESIS OF LIPOXINS (LX)%REACTOME%R-HSA-2142700.2 Synthesis of Lipoxins (LX) Hpgd Alox5 Alox12 Alox5ap Ptgr1 Ltc4s ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC%REACTOME DATABASE ID RELEASE 59%983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC H2-M3 H2-M5 Sar1b Canx Sec31a H2-Q1 Calr Tapbp Sec24a Sec24b Hspa5 Sec23a Erap1 Pdia3 Sec13 Tap1 Sec24d Tap2 H2-Q10 Sec24c B2m ACTIVATION OF ANTERIOR HOX GENES IN HINDBRAIN DEVELOPMENT DURING EARLY EMBRYOGENESIS%REACTOME DATABASE ID RELEASE 59%5617472 Activation of anterior HOX genes in hindbrain development during early embryogenesis Rara Egr2 Paxip1 Suz12 Kmt2c Rarb Hoxa4 Hoxa1 Hoxa3 Ctcf Hoxd1 Cnot6 Hoxd4 Hoxd3 Pias2 Kdm6a Hoxc4 Zfp335 Hoxb4 Hoxb3 Hoxb2 Hoxb1 Kmt2d Hist2h3c1 Rbbp4 Mafb Hoxa2 Yy1 Pknox1 H2afj Meis1 Polr2i H2afb2 Polr2f Polr2e Polr2j Polr2h Polr2c Polr2d Ncor1 Jun Polr2b Polr2g Polr2k Pbx1 Crebbp Hist2h2be Hist3h2ba Rqcd1 Ep300 Polr2a Hist2h2ac Ajuba H3f3b Ncoa3 H3f3a Pax6 Hist1h2bg Hist1h2bh Eed Hist1h2bp Hist1h2bm Hist1h2bj Ezh2 Rbbp7 Hist1h2bb H2afz Rarg H2afx Hist2h2aa1 Rxra Hist1h3d Pcgf2 Hist1h2ak Ash2l Wdr5 Hist1h2ag Rbbp5 Ncoa6 Hist1h2ah Hdac3 HDR THROUGH SINGLE STRAND ANNEALING (SSA)%REACTOME DATABASE ID RELEASE 59%5685938 HDR through Single Strand Annealing (SSA) Rbbp8 Topbp1 Trex1 Rfc5 Rad9a Blm Rfc3 Rad1 Rad9b Hus1 Rfc2 Rad50 Rfc4 Exo1 Brip1 Rad52 Rad51 Nbn Atrip Dna2 Kat5 Wrn Bard1 Brca1 Rpa2 Mre11a Rpa1 Atm Rpa3 Abl1 Top3a Ercc4 Rad17 Ercc1 TRAF3 DEFICIENCY - HSE%REACTOME%R-HSA-5602571.1 TRAF3 deficiency - HSE Traf3 Ticam1 Tlr3 HIV INFECTION%REACTOME%R-HSA-162906.1 HIV Infection Xrcc5 Nup85 Xrcc6 Nup160 Cdk9 Xpo1 Btrc Taf1 Taf2 Taf4b Taf7 Taf4a Rngtt Taf5 Taf6 Rnmt Taf3 Rac1 Npm1 Taf9 Ccnt1 Psip1 Nedd4l Banf1 Nup107 Lig1 Fen1 Ccnt2 Taf13 Ap2m1 Taf11 Nup37 Nup43 Nup133 Ap2a1 Ap2a2 Ccr5 Taf12 Cxcr4 Ap2s1 Ap2b1 Atp6v1h Ranbp2 Lig4 Nup50 Tpr Psmf1 Ndc1 Psme4 Nup214 Aaas Nup210 Skp1a Nup188 Nup54 Nup35 Nupl2 Nup62 Nup205 Nup155 Nup88 Psme3 Pom121 Rae1 Nup93 Nup153 Furin Ssrp1 Ran Gtf2h1 Gtf2h2 Gtf2h5 Gtf2h4 Cd8b1 Psma7 Cul5 Gtf2h3 Psmb5 Psmb4 Ubc Psmb7 Psmb6 Psmb2 Psmb3 Psmb1 Ppia Tcea1 Tceb1 Kpnb1 Tceb3 Psme2 Supt16 Psme1 Kpna1 Ap1s2 Ap1b1 Ap1s1 Ap1g1 Psmb10 Pacs1 H2-Q10 Xrcc4 Ap1s3 Cdk7 Psmb11 B2m Ap1m2 Ap1m1 Gtf2a1 Gtf2a2 Gtf2b Hmga1 Elmo1 Polr2i Gtf2e1 Polr2j Nelfa Gtf2e2 Nelfb Polr2c Mnat1 Polr2d Supt4a Polr2b Slc25a4 Polr2g Ctdp1 Polr2a Nelfe Supt5 Nelfcd Gtf2f1 Ncbp1 Ncbp2 Gtf2f2 Chmp5 Chmp7 Chmp6 Chmp3 Rbx1 Vps37d Rcc1 Vps37c Vps37b Pdcd6ip Psmd12 Tonsl Vps4b Psmd11 Vps4a Vta1 Chmp2a Chmp4c Chmp4b Ercc3 Psmd14 Psmd13 Psmd10 Nmt2 Vps37a Ranbp1 Nmt1 Ercc2 Shfm1 Pak2 Dock2 Tsg101 Lck Cd4 Psmc6 Psmc5 Psmc2 Psmd2 Psmb9 Psmb8 Psmc1 Arf1 Psmc4 Psmc3 Polr2f Fyn Hck Polr2e Polr2h Tbp Ell Taf9b Polr2k Slc25a5 Psma5 Psma4 Psma3 Psma6 Psma2 Psma1 Psmd9 Ak6 Psmd1 Psmd3 Psmd4 Ccnh Psmd6 Psmd5 Ccnk Psmd7 Psmd8 LEUKOTRIENE RECEPTORS%REACTOME DATABASE ID RELEASE 59%391906 Leukotriene receptors Cysltr1 Ltb4r2 Ltb4r1 Gpr17 Cysltr2 ACTIVATED PKN1 STIMULATES TRANSCRIPTION OF AR (ANDROGEN RECEPTOR) REGULATED GENES KLK2 AND KLK3%REACTOME%R-HSA-5625886.1 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 Hist1h2bg Hist1h2bh Ar Hist1h2bp Hist1h2bm Kdm4c Hist1h2bj Hist1h2bb Hist2h3c1 H2afz H2afx Pkn1 H2afj H2afb2 Hist2h2aa1 Hist1h3d Kdm1a Hist1h2ak Hist3h2ba Hist2h2be Hist1h2ag Hist2h2ac H3f3b Hist1h2ah Ncoa2 H3f3a CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE%REACTOME DATABASE ID RELEASE 59%211897 Cytochrome P450 - arranged by substrate type Cyp2u1 Cyp21a1 Cyp26c1 Cyp7a1 Cyp7b1 Cyp3a57 Nr1h4 Cyp3a16 Cyp4f18 Cyp4f17 Cyp4f15 Cyp3a13 Arnt Cyp2r1 Cyp4b1 Cyp19a1 Cyp2a5 Tbxas1 Por Cyp4a32 Cyp4f14 Cyp11b1 Cyp4f39 Cyp11b2 Cyp51 Fdx1 Fdx1l Cyp2s1 Ahr Cyp2j6 Cyp11a1 Fdxr Cyp46a1 Cyp27a1 Cyp39a1 Cyp4a12b Cyp1a2 Cyp27b1 Cyp26b1 Cyp4v3 Ptgis Cyp1a1 Cyp2d22 Cyp2e1 Pomc Arnt2 Cyp8b1 Cyp17a1 Cyp24a1 Cyp2w1 Cyp2f2 Cyp2c65 Rxra Cyp26a1 Cyp2b10 Cyp1b1 Ncoa1 Cyp4f40 Cyp2c50 Cyp2c55 Ncoa2 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN%REACTOME DATABASE ID RELEASE 59%174154 APC C:Cdc20 mediated degradation of Securin Psmc6 Psmc5 Psmc2 Psmd2 Psmb9 Psmf1 Psmb8 Psme4 Psmc1 Psmc4 Psmc3 Anapc15 Psme3 Anapc11 Anapc10 Pttg1 Psmd12 Psma7 Psmd11 Psmd14 Psma5 Psmb5 Psmb4 Ubc Psmd13 Psmd10 Psma4 Psmb7 Psma3 Psma6 Psmb6 Psmb2 Psmb3 Psmb1 Psma2 Psma1 Psmd9 Cdc23 Ube2d1 Cdc27 Cdc16 Cdc20 Ube2c Anapc16 Ube2e1 Psmd1 Anapc7 Shfm1 Psme2 Anapc4 Anapc5 Psme1 Anapc1 Anapc2 Psmd3 Psmd4 Psmb10 Psmd6 Psmd5 Psmd7 Psmb11 Psmd8 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES%REACTOME%R-HSA-450282.1 MAPK targets Nuclear events mediated by MAP kinases Ppp2cb Ppp2ca Ppp2r1a Mapk9 Ppp2r5d Vrk3 Mapk3 Elk1 Rps6ka5 Mapk10 Mapk1 Mef2c Mef2a Dusp3 Ppp2r1b Creb1 Dusp7 Mapk7 Mapkapk2 Rps6ka3 Dusp6 Rps6ka2 Rps6ka1 Jun Mapk8 Mapk11 Atf2 Mapk14 Fos Dusp4 MICROTUBULE-DEPENDENT TRAFFICKING OF CONNEXONS FROM GOLGI TO THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 59%190840 Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane Gja1 SHC1 EVENTS IN ERBB4 SIGNALING%REACTOME%R-HSA-1250347.2 SHC1 events in ERBB4 signaling Sos1 Shc1 Nrg2 Ereg Nrg3 Hbegf Nrg4 Kras Nrg1 Btc Nras Hras HYDROLYSIS OF LPE%REACTOME%R-HSA-1483152.3 Hydrolysis of LPE Pla2g4c Gpcpd1 EFFECTS OF PIP2 HYDROLYSIS%REACTOME%R-HSA-114508.2 Effects of PIP2 hydrolysis Daglb Abhd12 Trpc6 Prkcd Prkce Dgkq Dagla Dgkh Dgki Dgkb Dgka Prkcq Dgke Prkch Mgll Dgkg Abhd6 Rasgrp1 Itpr1 Rasgrp2 Dgkz Trpc3 Itpr3 Itpr2 Trpc7 ARYL HYDROCARBON RECEPTOR SIGNALLING%REACTOME DATABASE ID RELEASE 59%8937144 Aryl hydrocarbon receptor signalling Ahr Arnt Hsp90ab1 Aip Ahrr Arnt2 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS%REACTOME DATABASE ID RELEASE 59%159234 Transport of Mature mRNAs Derived from Intronless Transcripts Fip1l1 Nup85 Sympk Nup160 Nup37 Nup50 Nup43 Tpr Nup133 Cpsf3 Cpsf2 Nxf1 Cpsf4 Ndc1 Nup214 Aaas Nup210 Nup188 Nup54 Nup35 Nupl2 Nup62 Wdr33 Nup205 Nup155 Nup88 Pom121 Rae1 Slbp Nup93 Nup153 Eif4e Cpsf1 Ranbp2 Nup107 Ncbp1 Ncbp2 Alyref SIGNALING BY FGFR1 IN DISEASE%REACTOME DATABASE ID RELEASE 59%5655302 Signaling by FGFR1 in disease Fgf23 Bcr Fgf20 Fgfr1 Frs2 Stat5b Myo18a Nras Trim24 Stat5a Bag4 Cux1 Plcg1 Erlin2 Fgfr1op2 Hras Stat3 Gab2 Cpsf6 Fgf1 Zmym2 Gab1 Fgf2 Fgf9 Fgf6 Fgf4 Stat1 Kras Pik3ca Sos1 Pik3r1 Fgfr1op DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA%REACTOME DATABASE ID RELEASE 59%3359475 Defective MMAA causes methylmalonic aciduria type cblA Mut Mmaa CYCLIN B2 MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 59%157881 Cyclin B2 mediated events Ccnb2 Cdk1 Cdc25c Cdc25b Cdc25a AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1%REACTOME%R-HSA-349425.2 Autodegradation of the E3 ubiquitin ligase COP1 Psmc6 Psmc5 Psmc2 Psmd2 Psmd12 Psma7 Psmd11 Psmb9 Psmf1 Psmb8 Psma5 Psme4 Psmd14 Psmb5 Psmb4 Ubc Psmd13 Psma4 Psmd10 Psmb7 Psma3 Psma6 Psmb6 Psmb2 Psmc1 Psmb3 Psmc4 Psmb1 Psma2 Psmc3 Psma1 Psme3 Psmd9 Trp53 Psmd1 Shfm1 Psme2 Psme1 Rfwd2 Psmd3 Psmd4 Psmb10 Psmd6 Atm Psmd5 Psmd7 Psmb11 Psmd8 BIOGENIC AMINES ARE OXIDATIVELY DEAMINATED TO ALDEHYDES BY MAOA AND MAOB%REACTOME DATABASE ID RELEASE 59%141333 Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB Maob Maoa APOBEC3G MEDIATED RESISTANCE TO HIV-1 INFECTION%REACTOME%R-HSA-180689.1 APOBEC3G mediated resistance to HIV-1 infection Psip1 Banf1 Hmga1 Ppia PI3K CASCADE%REACTOME%R-HSA-109704.2 PI3K Cascade Prkag2 Pik3c3 Prkag1 Fgf23 Prkag3 Fgf22 Prkaa2 Tsc2 Fgf20 Frs2 Pik3r4 Mlst8 Fgf1 Gab1 Fgf2 Mtor Prkaa1 Fgf9 Pik3cb Fgf7 Fgf6 Fgf4 Fgf3 Rptor Pik3ca Lamtor1 Pde3b Lamtor2 Ppm1a Tlr9 Lamtor5 Akt2 Rragd Rragb Rragc Rraga Tsc1 Eif4b Lamtor4 Fgfr4 Akt1s1 Prkab1 Akt1 Ywhab Stk11 Fgf16 Fgf15 Prkab2 Klb Fgf18 Them4 Cab39 Eif4e Strada Irs2 Pdpk1 Stradb Cab39l Eef2k Eif4g1 Irs1 Eif4ebp1 Pik3r1 Ptpn11 Fgf10 Pik3r2 Trib3 GENERATION OF SECOND MESSENGER MOLECULES%REACTOME%R-HSA-202433.2 Generation of second messenger molecules Pak1 Pak3 Pak2 Plcg1 Vasp H2-Aa Cd3d Cd3e H2-Eb1 Lck Cd101 Was Zap70 Cd4 Fyb Lat Nck1 Grap2 Cd3g Itk Lcp2 Evl NEGATIVE REGULATION OF FGFR4 SIGNALING%REACTOME%R-HSA-5654733.1 Negative regulation of FGFR4 signaling Ppp2cb Spry2 Fgf23 Fgf16 Ppp2ca Fgf15 Fgf20 Frs2 Klb Fgf18 Ppp2r1a Fgfr4 Mknk1 Fgf1 Braf Ubc Cbl Fgf2 Fgf9 Mapk3 Ptpn11 Fgf6 Fgf4 Mapk1 TP53 REGULATES TRANSCRIPTION OF DNA REPAIR GENES%REACTOME%R-HSA-6796648.3 TP53 Regulates Transcription of DNA Repair Genes Cdk9 Msh2 Cdk12 Cdk13 Polr2f Polr2i Polr2e Polr2j Polr2h Ddb2 Nelfa Nelfb Ell Mnat1 Polr2c Polr2d Supt4a Jun Polr2b Polr2g Polr2k Atf2 Ctdp1 Ccnt1 Ssrp1 Atm Fos Polr2a Fancc Nelfe Fanci Supt5 Mlh1 Nelfcd Gtf2h1 Gtf2f1 Ccnt2 Gtf2h2 Gtf2f2 Gtf2h5 Chek1 Gtf2h4 Rsph10b Gtf2h3 Ercc3 Mdc1 Fancd2 Pms2 Ercc2 Trp53 Tcea1 Tceb1 Tceb3 Supt16 Brca1 Ccnh Rad51d Ccnk Cdk7 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM%REACTOME%R-HSA-535734.5 Fatty acid, triacylglycerol, and ketone body metabolism Acat1 Prkaa2 Mtf1 Srebf2 Cdk8 Nrf1 Thrap3 H2-Ke6 Lclat1 Arntl Hmgcll1 Mogat1 Mogat2 Acot9 Cyp4a32 Acot7 Cbr4 Ahr Grhl1 Acot11 Acot12 Acot13 Mcat Echs1 Fhl2 Hadhb Aacs Acadm Hadha Hadh Ep300 Olah Apoa1 Ncoa3 Txnrd1 Med31 Glipr1 Med1 Nr1d1 Tbl1x Sult2a1 Med30 Agt Ctgf Cyp1a1 Med4 Arnt2 Med8 Med6 Slc25a1 Acot2 Acot3 Acot4 Fdft1 Med9 Mcee Ugt1a9 Cd36 Ahrr Prkag2 Cdk19 Fads1 Abcb4 Eci1 Med13 Med14 Fam120b Med12 Acly Med10 Rgl1 Gk2 Chd9 Clock Med16 Med17 Acbd7 Lpcat4 Acbd6 Med15 Acad12 Tnfrsf21 Acad10 Acad11 Acaa2 Agk Pnpla5 Rora Ncor1 Ncor2 Acsm3 Med13l Ndufab1 Oxct1 Smarcd3 G0s2 Ppard Med22 Bdh2 Bdh1 Med28 Med29 Ppara Med21 Pparg Med11 Me1 Yap1 Med19 Decr2 Decr1 Ppargc1b Ankrd1 Ppargc1a Wwtr1 Gyk Apoa5 Acadl Hmgcs2 Plin2 Prkab2 Dbi Scd1 Acsf2 Them5 Med18 Mut Mmaa Gpd2 Hmgcl Pex11a Npas2 Angptl4 Acads Nfyb Nfyc Helz2 Cyp7a1 Acot8 Nr1h4 Ppt2 Hsd17b3 Nfya Hacd2 Hacd3 Hacd1 Ppt1 Acsl3 Acsf3 Hsd17b12 Apoa2 Hacd4 Acsbg1 Acsl6 Fasn Acsl5 Acsl4 Elovl7 Acsbg2 Slc27a3 Acsl1 Elovl6 Tecr Tecrl Elovl1 Elovl5 Elovl4 Elovl3 Elovl2 Med20 Dgat2 Med27 Med26 Med23 Dgat1 Med24 Plin3 Med25 Pcca Acaca Pccb Havcr2 Lpcat1 Rxra Carm1 Sin3a Gpd1l Tbl1xr1 Trib3 Gpd1 Ccnc Tead3 Tead1 Tead2 Sp1 Arnt Agpat6 Agpat5 Alas1 Awat2 Gpam Abca1 Esrra Lpin2 Fabp1 Slc27a1 Crebbp Cpt1b Slc25a20 Cpt2 Cpt1a Mid1ip1 Lpin3 Thrsp Lpin1 Acadvl Tiam2 Pctp Tead4 Agpat3 Agpat4 Them4 Agpat1 Agpat2 Agpat9 Ncoa1 Ncoa6 Ncoa2 Hdac3 Gpat2 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER%REACTOME%R-HSA-2644602.1 Signaling by NOTCH1 PEST Domain Mutants in Cancer Hdac4 Hdac5 Ccnc Cdk8 Notch1 Skp1a Hdac1 Cul1 Maml2 Aph1b Maml1 Hdac2 Ncor1 Ncor2 Mib2 Crebbp Hdac10 Neurl1a Neurl1b Hey1 Hdac11 Ep300 Hey2 Hdac7 Hdac6 Hdac9 Hdac8 Hes5 Rbpj Kat2b Mib1 Kat2a Heyl Hes1 Adam10 Rbx1 Tbl1x Maml3 Ubc Myc Psen2 Ncstn Mamld1 Adam17 Jag2 Dll1 Tbl1xr1 Dll4 Jag1 Hdac3 SIGNALING BY FGFR2%REACTOME%R-HSA-5654738.2 Signaling by FGFR2 Fgf23 Fgf22 Rbfox2 Fgf20 Frs2 Nras Ppp2r1a Frs3 Esrp2 Tia1 Hras Tial1 Fgf1 Gab1 Fgf2 Fgf9 Hnrnpm Hnrnpf Fgf7 Fgf6 Fgf4 Fgf3 Polr2f Polr2i Polr2e Polr2j Polr2h Polr2c Polr2d Polr2b Polr2g Polr2k Pik3ca Polr2a Fgfbp3 Hnrnpa1 Gtf2f1 Ncbp1 Ncbp2 Fgfbp1 Gtf2f2 Ppp2cb Spry2 Ppp2ca Ptbp1 Plcg1 Mknk1 Ubc Cbl Mapk3 Mapk1 Hnrnph1 Fgf16 Kras Fgf18 Sos1 Braf Pik3r1 Ptpn11 Fgf10 INTERLEUKIN-4 AND 13 SIGNALING%REACTOME DATABASE ID RELEASE 59%6785807 Interleukin-4 and 13 signaling Pou2f1 Il2rg Saa3 Hif1a Hsp90b1 Twist1 Sox2 Il4 Mmp2 Il6 Mmp9 Ccl12 Fcer2a Col1a2 Tnfrsf1b Lif Tnf Birc5 Jak1 Fasl Osm Timp1 Il12b Cdkn1a Hspa8 Il12a Il10 Il13 Anxa1 Tyk2 Stat3 Icam1 Itgb2 Ptgs2 Socs1 Gata3 Vegfa Socs5 Itgam Ccl22 Pomc Il1b Il1a Il18 Bcl2 Junb Bcl2l1 Il17f Il17a Cd36 Vim Maoa Oprm1 F13a1 Mcl1 Il4ra Itgb1 Irf4 Hmox1 Il13ra2 Il13ra1 Zeb1 Hsp90aa1 Alox5 Bcl6 Fgf2 Foxo3 Rorc Foxo1 Ccnd1 Rora Stat1 Stat6 Lbp S1pr1 Alox15 Fos Muc1 Hgf Batf Lcn2 Jak2 Il23r Il23a Jak3 Ndn Socs3 Myc Oprd1 Pim1 Fscn1 Akt1 Il6ra Lama5 Mmp1a Tgfb1 Vcam1 Trp53 Itgax Fn1 Nos2 Mmp3 Pik3r1 Ccl11 Rhou MELANIN BIOSYNTHESIS%REACTOME%R-HSA-5662702.2 Melanin biosynthesis Oca2 Tyr Tyrp1 Dct Slc45a2 G1 S-SPECIFIC TRANSCRIPTION%REACTOME DATABASE ID RELEASE 59%69205 G1 S-Specific Transcription Fbxo5 Cdt1 Cdc45 Pcna Orc1 Ccne1 Cdc6 Cdk1 E2f1 Rrm2 Ccna1 Pola1 Tyms Cdc25a Dhfr Tk2 Tfdp2 Tfdp1 HEMOSTASIS%REACTOME DATABASE ID RELEASE 59%109582 Hemostasis Thpo G6b Gp1bb Gp1ba Serpine1 Tgfb3 Tgfb2 Tspan7 Pick1 Gp5 Mpl Gp9 Prkcb Gp6 Pfn1 Angpt2 Klc3 Klc2 Klc4 Angpt4 Grb14 Dok2 Pafah2 Kdm1a Racgap1 H3f3b H3f3a Serpinb8 Serpinb2 Vegfa S100a10 Itgav Ppil2 Klc1 Spn Slc3a2 C1qbp F12 Aldoa F11 L1cam Vav2 Hist1h3d Slc7a5 Kif4 Itga1 Itga2 Itga10 Itga5 F2rl3 F2rl2 P2rx4 P2rx5 Rapgef4 Cd2 Rapgef3 Selplg Hist2h3c1 Cd84 Mertk Glg1 Cd99l2 Cd48 Csk Sele Pla2g4a Trem1 Esam Vpreb2 Fcamr Cd244 Epcam Vpreb3 Gypc P2rx2 P2rx1 P2rx7 P2rx6 P2rx3 Slc16a3 Gna11 Slc16a1 Gna12 F2r Rhog Bsg Gnaq Rhob Slc16a8 Gna15 F2 Gna13 Gna14 Ptgir Igf2 Igf1 P2ry12 Slc8a2 Slc8a1 Atp1b2 Gab2 Slc8a3 Atp1b3 Atp1b1 Atp2a1 Atp2a3 Atp2a2 Atp2b3 Atp2b4 Atp2b1 Atp2b2 Vegfb Vegfc Sri Figf Grb7 Prkcd Prkce Actn2 Prkcg Plg Brpf3 Prkca Vav1 Dgkb Il2rg Arrb2 Dgka Pde10a Arrb1 Hdac1 Vwf Dgke Dgkg Sytl4 Fermt3 Apoh Wdr1 Serping1 Srgn Gas6 Serpinf2 Fam49b Cyb5r1 Maged2 A1bg Lgals3bp Nhlrc2 Pcyox1l Rasgrp2 Calu Endod1 Fam3c Lhfpl2 Manf Chid1 Aplp2 Habp4 Pcdh7 Apool Cdc37l1 Serpina3n Tor4a Islr Pde3b Fgg Pdgfb Itgb2 Il2 Itgam Il5 P2ry1 Ppp2r1b Kras Itpr1 Lck Ptpn6 Il3ra Il2ra Il2rb Itpr3 Ptpn11 Angpt1 Itpr2 Gngt1 Egf Gng7 Abhd12 Tbxa2r Gng4 Gngt2 Gng10 Prkacb Nos3 Stxbp3 Tek Hras Prkar2b Ppp2r5e Ppp2r5c Ppp2r5d Pik3r6 Ppp2r5a Pik3r5 Pik3cb Pik3cd Itgb3 Gnai2 Stim1 Fyn Gnai1 Orai1 Gnai3 Orai2 Fgr Prkg2 Plcg2 Tuba4a Cav1 Ppp2r5b Rasgrp1 Syk Tln1 Gng11 Pik3ca Gng13 Crebbp Gng12 Gnb2 Gnb1 A2m Gnb3 Gnb5 Fga Fgb Gnb4 Prkaca Thbs1 Abl1 Gng8 Vav3 Gng3 Gng2 Hgf Tex264 Psap Ahsg Alb Wee1 Ywhaz Abcc4 Cfd Jak2 Cap1 Ola1 Dgkq Itga2b Clec3b Ctsw Rap1a Jak3 Rab27b Hrg Selp Rap1b Dgkh Cd109 Scg3 Hspa5 Stxbp2 Dgki Lamp2 Sccpdh Phactr2 Sepp1 Plat Gtpbp2 Clu Tagln2 Tmx3 Timp3 Pecam1 Vcl Ttn Spp2 Orm3 Cd9 Plek Vti1b Qsox1 Ecm1 Mmp1a Mmrn1 Lefty2 Anxa5 Itih3 Tgfb1 Rarres2 Cd63 Itih4 Kif5a Mag Kif5b Itgax Abhd6 Fn1 Prkcz Bcar1 Klkb1 Sparc Nos1 Pdpk1 Pik3r3 Nos2 Dgkz Crk Pde11a Pik3r1 Cd44 Pik3r2 Amica1 Itga6 Trpc6 Pdpn Clec1b Ppp2r1a Gata4 Lat Hdac2 App Itga3 Rac1 F11r Anxa2 Actn1 Actn4 Sell Csf2 Ep300 Trpc3 Apoa1 Cenpe Apob Trpc7 Kif2c Daglb Kif2b Jak1 Kif18a Timp1 Stx4a Dagla Kif2a Jam2 Mgll Jam3 Pde3a Plau Pde2a Prcp Trf Gnat3 Cd36 Jchain F9 F7 F13a1 Procr F10 Pros1 Prkar2a Thbd Cd74 Nras Prtn3 Serpine2 F13b Cd177 Pf4 Serpina5 Raf1 Proc Il5ra Cdk2 Serpind1 Serpinc1 Ptk2 Serpinb6a Slc7a6 Slc7a9 Slc7a8 Slc7a7 Prkar1a Prkar1b Plaur Ppp2cb Ptpn1 Slc7a10 Shc1 Ppp2ca Slc7a11 Akt2 Akt3 Itga4 Plcg1 Adra2a Adra2c Adra2b Itgal Cxadr Mapk3 Akt1 Mapk1 Ppia Kng2 Ppbp Trp53 Pde1b Pde1a Sos1 Apbb1ip Pik3cg Csf2rb2 Csf2ra Lcp2 Dock1 Rhoa Gucy1b3 Pde9a Gucy1a2 Gucy1a3 Pde5a F5 F8 Kcnmb2 Kcnma1 Kcnmb4 Mrvi1 Kcnmb1 Dock5 Dock6 Dock3 Dock4 Tnfrsf10b Rab5a Gata2 Kif3c Rcor1 Kif3b Kif3a Dock7 Dock8 Yes1 Kif18b Lyn Capza1 Sh2b3 Capza2 Capzb Sh2b2 Gata5 Prkcq Gata6 Gata3 Gata1 Dock11 Dock10 Kifc5b Sh2b1 Kifc2 Ifnb1 Lrrc16a Akap1 Prkch Cables1 Hmg20b F3 Kif16b Kif26a Tfpi Cables2 Serpina1d Ehd3 Ehd2 Ehd1 Mafg Maff Serpina1a Vps45 Hbb-bh1 Kif26b Dock2 Kif13b Mafk Kif20b Cbx5 Mfn2 Kif20a Itpk1 Myb Rac2 Kifap3 Sin3a Nfe2 Kif22 Akap10 Hbb-bt Kif27 Mfn1 Cdk5 Kif23 Kif9 Rbsn Irf7 Irf1 Ak3 Itgb1 Kif12 Kif15 Kif19a Kif6 Kif1c Kif21a Kif21b Hbb-bs Kif1b Mif Kif1a Irf2 Irf3 Jmjd1c Rad51b Rad51c Kif11 Zfpm1 Hbb-y Ifna16 Zfpm2 Inpp5d Fcer1g Flna Sirpa Sdc3 Sdc4 Sdc2 Sdc1 Olr1 Mapk14 Cd47 Gpc1 OPTINEURIN AND MYOSIN PHOSPHATASE NEGATIVELY REGULATE PLK1%REACTOME%R-HSA-2562597.1 Optineurin and Myosin Phosphatase Negatively Regulate PLK1 Optn Plk1 Rab8a PLC-GAMMA1 SIGNALLING%REACTOME DATABASE ID RELEASE 59%167021 PLC-gamma1 signalling Adcy7 Adcy6 Prkcd Adcy5 Prkce Adcy4 Adcy3 Adcy2 Prkar2a Prkcg Adcy1 Prkacb Adcy9 Plcg1 Adcy8 Prkca Prkar2b Adrbk1 Ntrk1 Creb1 Ngf Pde1c Camk4 Pde1b Pde1a Itpr1 Prkar1a Prkar1b Ahcyl1 Prkaca Itpr3 Itpr2 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS%REACTOME DATABASE ID RELEASE 59%205043 NRIF signals cell death from the nucleus Ngf Ubc Traf6 Mapk8 Psen2 Ncstn Sqstm1 Itgb3bp Aph1b Ngfr TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 59%168188 Toll Like Receptor TLR6:TLR2 Cascade Ppp2r1a Btrc Mapk9 Nfkb2 Nfkb1 Ecsit Fbxw11 Skp1a Saa3 Ppp2r5d Mapkapk3 Tnip2 Myd88 Nod2 Cul1 Nod1 Dhx9 Vrk3 S100b Elk1 Mef2c Mapk10 Mef2a Sigirr Dusp3 Map3k7 Mapk7 Irak3 Peli1 Creb1 Mapkapk2 Irak2 Irak1 App Map2k6 Tab1 Tab2 Jun Mapk8 Tab3 Map3k1 Ripk2 Map2k7 Ager Map2k3 Map2k4 Map3k8 Rela Atf2 Nfkbia Peli3 Nfkbib Irak4 Fos Peli2 Ppp2cb Map2k1 Chuk Ppp2ca Btk Tlr2 Tlr6 Ubc Socs1 Mapk3 Rps6ka5 Mapk1 Ppp2r1b Dusp7 Rps6ka3 Dusp6 Rps6ka2 Rps6ka1 Traf6 Ikbkb Ube2v1 Tlr4 Ube2n Ly96 Cd14 Ikbkg Mapk11 Cd36 Mapk14 Tlr1 Tirap Dusp4 TRKA ACTIVATION BY NGF%REACTOME%R-HSA-187042.1 TRKA activation by NGF Ngf Ntrk1 MAPK1 (ERK2) ACTIVATION%REACTOME%R-HSA-112411.1 MAPK1 (ERK2) activation Il6ra Il6 Jak1 Jak2 Map2k2 Ptpn11 Mapk1 Tyk2 CLATHRIN-MEDIATED ENDOCYTOSIS%REACTOME DATABASE ID RELEASE 59%8856828 Clathrin-mediated endocytosis Ldlr Rab5c Rab5b Slc18a3 Dvl2 Arrb2 Egfr Arrb1 Adrbk1 Arpc5 Arf6 Arpc4 Wasl Sh3gl1 Stam Hgs Ocrl Wnt5a Agtr1a Apob Stam2 Eps15 Cltb Vamp8 D130043K22Rik Ap2m1 Vamp3 Hspa8 Rab5a Necap1 Hip1r Tor1b Tor1a Picalm M6pr Pacsin3 Ap2a1 Pacsin2 Gak Pacsin1 Igf2r Ap2a2 Epn2 Cbl Fnbp1 Scarb2 Syt8 Aak1 Sh3gl2 Agfg1 Dnm2 Trip10 Ubqln2 Ubqln1 Bin1 Vamp4 Ap2s1 Dnm1 Cttn Tfrc Arpc1a Cops7b Itsn2 Amph Cops7a Trf Clta Ap2b1 Cops8 Cd3d Cops6 Cltc Cops2 Cops4 Avp Cops5 Synj2 Dnm3 Avpr2 Cd4 Eps15l1 Cops3 Epn1 Fzd4 Lrp2 Itsn1 Synj1 Snx9 Cd3g Gapvd1 Egf Arfgap1 Pik3c2a Chrm2 Slc2a8 Dab2 Necap2 Snap91 Syt11 Sh3kbp1 Hip1 Syt9 Snx18 Reps1 Sgip1 Fcho2 Fcho1 Fnbp1l Syt2 Reps2 Adrb2 Ston2 Cftr Ubc Tacr1 Pip5k1c Actr2 Actr3 Nedd8 Dnajc6 Arpc3 Syt1 Vamp7 Vamp2 Arpc2 Adrbk2 Ldlrap1 PURINE CATABOLISM%REACTOME%R-HSA-74259.2 Purine catabolism Pnp Cat Gpx1 Nt5c1a Nt5e Nt5c Nt5c2 Gda Xdh PEPTIDE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 59%375276 Peptide ligand-binding receptors C5ar2 Nts Oprk1 Rxfp1 Rxfp2 Npff Rxfp4 Rxfp3 Saa3 Cxcl2 Cxcl9 Cxcl5 Gper1 App Ccl25 Ccl28 Hc Galr2 Agtr2 Prok1 Mchr1 Prok2 Hebp1 Agtr1a Ccl5 Cxcr1 Fpr1 Pmch Ednra Ccr1 Ednrb Prokr1 Rln3 Agt Rln1 Oprl1 Prokr2 Qrfp Hcrtr1 Anxa1 Hcrtr2 Cxcr2 Cxcr3 Nmur1 Nmur2 Galr1 Cckar Cxcl3 Cxcl1 Fpr3 Xcl1 Pomc Ccl20 Cxcr6 Ccr2 Fpr2 Ccr5 Cxcr4 Cxcl10 Cxcr5 Apln C3ar1 Tac2 Tac1 Pyy Avp Avpr1a Avpr2 Avpr1b Npffr1 Cck Npffr2 Cckbr Aplnr Oprm1 Grp F2rl3 F2rl2 Sst Nmb Gal Ackr3 Pf4 Qrfpr Nmu Oxt Trhr Npy1r Nms Kiss1r Kiss1 F2rl1 Grpr Mc5r Prlhr Ntsr1 Xk Ntsr2 Xcr1 Ackr1 Ghsr Uts2b Npy5r Ece2 Uts2r Ece1 Gpr37l1 Npy4r Kel Prlh Sstr2 Nln Sstr1 Pnoc Npy2r Sstr5 Npbwr1 Sstr3 Sstr4 Trh Ppy Mc2r Cort Npb Npy Gpr37 C5ar1 Npw F2r Nmbr Edn1 F2 Edn3 Nps Edn2 Mc1r Psap Penk C3 Uts2 Brs3 Hcrt Gcat Ccr9 Npsr1 Ccr8 Ccr7 Ccr6 Ccr4 Ccr3 Oprd1 Mc3r Pdyn Mc4r Cxcl16 Ccr10 Tacr2 Cxcl13 Tacr3 Bdkrb1 Tacr1 Cxcl12 Cxcl11 Bdkrb2 Kng2 Cx3cl1 Ackr4 Ccl2 Ccl1 Ppbp Cx3cr1 Ccrl2 Insl5 Insl3 Oxtr FATTY ACYL-COA BIOSYNTHESIS%REACTOME%R-HSA-75105.5 Fatty Acyl-CoA Biosynthesis Acot8 Ppt2 Hsd17b3 Hacd2 Acly Hacd3 Hacd1 Ppt1 Acsl3 Acsf3 Hsd17b12 Hacd4 Acbd7 Acsbg1 Acbd6 Acsl6 Fasn Acot9 Acsl5 Acsl4 Elovl7 Acot7 Acsbg2 Slc27a3 Agk Acsl1 Elovl6 Tecr Tecrl Elovl1 Elovl5 Elovl4 Elovl3 Elovl2 Acot11 Acot12 Acot13 Olah Acaca Slc25a1 Pctp Acot2 Acot3 Acot4 Dbi Scd1 Them4 Acsf2 Them5 FGFR1B LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 59%190370 FGFR1b ligand binding and activation Fgf1 Fgf22 Fgf2 Fgf10 Fgf3 PHOSPHORYLATION OF THE APC C%REACTOME%R-HSA-176412.2 Phosphorylation of the APC C Cdc23 Ube2d1 Cdc27 Cdc16 Ube2c Anapc16 Plk1 Ube2e1 Anapc7 Anapc4 Anapc5 Anapc1 Anapc2 Cdk1 Anapc15 Anapc11 Anapc10 DNA REPLICATION INITIATION%REACTOME%R-HSA-68952.2 DNA replication initiation Prim1 Pole2 Pole Pola1 Pola2 Pole4 Prim2 Pole3 ACTIVATION OF RAC%REACTOME DATABASE ID RELEASE 59%428540 Activation of Rac Rac1 Pak1 Pak3 Slit2 Pak2 Nck2 Pak7 Sos2 Sos1 Pak4 Robo1 Pak6 Nck1 Gpc1 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R)%REACTOME DATABASE ID RELEASE 59%2404192 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) Pik3c3 Cilp Prkaa2 Akap9 Ppp2r1a Pik3r4 Prkaa1 Csf2 Jak1 Tsc1 Prkag2 Prkag1 Prkag3 Frs2 Nras Frs3 Rasgrf1 Psmf1 Raf1 Psme4 Il5ra Fgf1 Il17rd Fgf2 Cnksr1 Csk Cnksr2 Erbb2 Fgf9 Ptk2 Fgf7 Psme3 Fgf6 Fgf4 Fgf3 Ppp5c Ranbp9 Lamtor1 Ppp2cb Shc1 Lamtor2 Ppm1a Nrg2 Tlr9 Ppp2ca Igf1r Shc3 Lamtor5 Irs4 Nrg1 Igf2 Akt2 Igf1 Shc2 Psma7 Artn Nrtn Lamtor4 Brap Psmb5 Psmb4 Ubc Nrg3 Psmb7 Nrg4 Psmb6 Psmb2 Psmb3 Psmb1 Prkab1 Mapk3 Akt1 Mapk1 Ksr1 Ptpra Dusp16 Dusp10 Stk11 Map3k11 Prkab2 Paqr3 Psme2 Psme1 Ncam1 Sos1 Braf Psmb10 Apbb1ip Psmb11 Csf2rb2 Rapgef2 Csf2ra Actn2 Nf1 Tsc2 Pdgfrb Pdgfra Mlst8 Kbtbd7 Il2rg Arrb2 Egfr Gab1 Arrb1 Mtor Ret Vwf Rptor Sptan1 Pspn Pde3b Map2k1 Rbx1 Fgg Map2k2 Cul3 Rragd Psmd12 Rragb Pdgfb Rragc Psmd11 Rraga Rasgef1a Eif4b Psmd14 Rasa3 Rasa4 Psmd13 Psmd10 Il2 Rasa2 Rasa1 Nefl Spred3 Kit Spred2 Grin2a Spred1 Spta1 Il5 Sptbn4 Ppp2r1b Ywhab Kras Gdnf Shfm1 Cab39 Eif4e Strada Irs2 Stradb Cab39l Syngap1 Eef2k Hbegf Eif4g1 Irs1 Eif4ebp1 Il3ra Btc Il2ra Il2rb Angpt1 Ptpn11 Trib3 Psmc6 Egf Fgf23 Psmc5 Fgf22 Mark3 Psmc2 Fgf20 Psmd2 Dab2ip Tek Psmb9 Psmb8 Araf Hras Grin1 Ppp2r5e Dlg4 Ppp2r5c Ppp2r5d Ppp2r5a Psmc1 Psmc4 Psmc3 Pik3cb Sptbn2 Sptbn1 Itgb3 Fyn Phb Grin2c Rasgrp4 Rasgrp3 Pebp1 Ppp2r5b Rasgrp1 Tln1 Pik3ca Fga Fgb Grin2d Grin2b Sptb Hgf Gfra2 Gfra3 Gfra4 Ereg Jak2 Pea15a Itga2b Rap1a Jak3 Wdr83 Camk2d Rap1b Camk2a Fgfr4 Camk2b Psma5 Rasal3 Rasal2 Psma4 Psma3 Psma6 Akt1s1 Vcl Camk2g Psma2 Psma1 Gfra1 Psmd9 Dusp7 Iqgap1 Fgf16 Dusp6 Dusp9 Fgf15 Dusp8 Klb Fgf18 Them4 Psmd1 Met Fn1 Rasal1 Dusp1 Psmd3 Psmd4 Pdpk1 Psmd6 Psmd5 Dusp2 Psmd7 Pik3r1 Dusp5 Psmd8 Fgf10 Pik3r2 Dusp4 DISEASES OF CARBOHYDRATE METABOLISM%REACTOME DATABASE ID RELEASE 59%5663084 Diseases of carbohydrate metabolism Ppp1r3c Ubc Gys2 Gys1 Gyg Epm2a ACTIVATION OF MATRIX METALLOPROTEINASES%REACTOME%R-HSA-1592389.1 Activation of Matrix Metalloproteinases Timp1 Plg Ctrb1 Prss2 Mmp1a Mmp13 Mmp14 Timp2 Mmp17 Mmp15 Mmp11 Ctsg Mmp16 Ctsk Cma1 Ctsl Elane Mmp10 Klkb1 Furin Mmp2 Mmp9 Mmp25 Mmp24 Mmp3 Tpsb2 Spock3 Mmp8 Mmp7 Col18a1 AMER1 MUTANTS DESTABILIZE THE DESTRUCTION COMPLEX%REACTOME%R-HSA-4839748.1 AMER1 mutants destabilize the destruction complex Ppp2r1b Ppp2cb Apc Axin1 Ppp2ca Amer1 Csnk1a1 Gsk3b Ppp2r1a Ppp2r5b Ppp2r5e Ppp2r5c Ppp2r5d Ppp2r5a CELL-EXTRACELLULAR MATRIX INTERACTIONS%REACTOME%R-HSA-446353.1 Cell-extracellular matrix interactions Rsu1 Itgb1 Lims2 Ilk Actn1 Flnc Vasp Flna Pxn Tesk1 Arhgef6 Fblim1 Fermt2 Parvb Parva DNA DOUBLE STRAND BREAK RESPONSE%REACTOME%R-HSA-5693606.1 DNA Double Strand Break Response Hist1h2bg Hist1h2bh Smarca5 Fam175a Hist1h2bp Kdm4a Hist1h2bm Pias4 Apbb1 Kdm4b Hist1h2bj Rnf168 Hist1h2bb Eya3 Ube2v2 Ubc Eya2 Eya1 Brcc3 Eya4 Trp53bp1 Rad50 Baz1b Mdc1 H2afx Uimc1 Babam1 Herc2 Nbn Bre Trp53 Mapk8 Kat5 Bard1 Ube2n Bap1 Whsc1 Hist1h3h Brca1 Chek2 Mre11a Ppp5c Atm Hist2h2be Hist3h2ba Abl1 Ube2i UPTAKE AND FUNCTION OF DIPHTHERIA TOXIN%REACTOME DATABASE ID RELEASE 59%5336415 Uptake and function of diphtheria toxin Hbegf Eef2 Hsp90ab1 Cd9 Hsp90aa1 Txnrd1 SNRNP ASSEMBLY%REACTOME DATABASE ID RELEASE 59%191859 snRNP Assembly Nup85 Nup160 Nup37 Nup50 Gemin5 Gemin4 Nup43 Tpr Gemin7 Nup133 Ndc1 Smn1 Gemin2 Nup214 Aaas Nup210 Nup188 Nup54 Nup35 Prmt5 Nupl2 Snrpd2 Nup62 Nup205 Nup155 Snrpd1 Wdr77 Nup88 Pom121 Snrpb Snrpd3 Rae1 Nup93 Nup153 Phax Snupn Clns1a Ranbp2 Nup107 Ddx20 Ncbp1 Ncbp2 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER%REACTOME%R-HSA-3642279.1 TGFBR2 MSI Frameshift Mutants in Cancer Tgfb1 Tgfbr2 DNA DAMAGE REVERSAL%REACTOME%R-HSA-73942.1 DNA Damage Reversal Alkbh3 Ascc3 Alkbh2 Alkbh5 Ascc2 Ascc1 Mgmt Fto AGMATINE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 59%351143 Agmatine biosynthesis Agmat Azin2 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION%REACTOME%R-HSA-2029482.1 Regulation of actin dynamics for phagocytic cup formation Dock1 Actb Hsp90aa1 Vav1 Wipf3 Wipf2 Wipf1 Wasf2 Ptk2 Wasf3 Elmo1 Arpc5 Elmo2 Arpc4 Wasf1 Myo1c Fcgr4 Myo9b Myh2 Rac1 Myo10 Pak1 Fcgr3 Syk Fcgr1 Myo5a Wasl Was Abl1 Vav3 Actg1 Btk Nckap1l Baiap2 Nck1 Brk1 Mapk3 Abi1 Mapk1 Abi2 Limk1 Actr2 Arpc1a Actr3 Arpc1b Vav2 Nckipsd Nckap1 Hsp90ab1 Arpc3 Crk Arpc2 Myh9 Cyfip1 Cd3g Cyfip2 EARLY PHASE OF HIV LIFE CYCLE%REACTOME DATABASE ID RELEASE 59%162594 Early Phase of HIV Life Cycle Lig4 Xrcc5 Xrcc6 Hmga1 Kpna1 Psip1 Banf1 Cd4 Xrcc4 Ccr5 Lig1 Fen1 Cxcr4 Ppia PCNA-DEPENDENT LONG PATCH BASE EXCISION REPAIR%REACTOME%R-HSA-5651801.1 PCNA-Dependent Long Patch Base Excision Repair Pole Apex1 Pold1 Pold2 Pcna Pold3 Pold4 Polb Rfc5 Pole2 Rpa2 Rfc3 Rpa1 Rpa3 Rfc2 Lig1 Rfc4 Fen1 Pole4 Rfc1 Pole3 BETA OXIDATION OF HEXANOYL-COA TO BUTANOYL-COA%REACTOME%R-HSA-77350.2 Beta oxidation of hexanoyl-CoA to butanoyl-CoA Echs1 Hadhb Hadha Hadh Acads GABA B RECEPTOR ACTIVATION%REACTOME DATABASE ID RELEASE 59%977444 GABA B receptor activation Gngt1 Adcy7 Gng7 Adcy6 Adcy5 Gng4 Adcy4 Adcy3 Kcnj10 Adcy2 Gngt2 Kcnj3 Adcy1 Gng10 Kcnj16 Kcnj15 Adcy9 Adcy8 Kcnj6 Gnai2 Gnai1 Kcnj5 Kcnj9 Gnai3 Gnat3 Gnal Gabbr2 Gabbr1 Kcnj2 Gng12 Kcnj12 Gnb2 Gnb1 Kcnj4 Gnb3 Gng8 Gng3 Gng2 ORGANIC CATION ANION ZWITTERION TRANSPORT%REACTOME DATABASE ID RELEASE 59%549132 Organic cation anion zwitterion transport Slc22a12 Slc22a6 Slc22a16 Slc22a15 Slc22a2 Slc22a18 Slc22a8 Slc22a7 Slc22a1 Slc22a3 Slc22a4 Slc22a5 REGULATION OF COMMISSURAL AXON PATHFINDING BY SLIT AND ROBO%REACTOME%R-HSA-428542.1 Regulation of Commissural axon pathfinding by Slit and Robo Robo2 Robo1 Slit2 ACTIVATION OF RRNA EXPRESSION BY ERCC6 (CSB) AND EHMT2 (G9A)%REACTOME%R-HSA-427389.2 Activation of rRNA Expression by ERCC6 (CSB) and EHMT2 (G9a) Hist1h2bg Hist1h2bh Hist1h2bp Hist1h2bm Hist1h2bj Ercc6 Hist1h2bb Rbbp7 Mta2 Hist2h3c1 Hdac1 H2afz Rbbp4 H2afx Chd3 Chd4 H2afj H2afb2 Hdac2 Hist2h2aa1 Gatad2a Gatad2b Hist1h3d Mbd3 Ehmt2 Hist1h2ak Hist2h2be Hist3h2ba Hist1h2ag Cbx3 Hist2h2ac Ttf1 Mta1 H3f3b H3f3a Mta3 Hist1h2ah CELL SURFACE INTERACTIONS AT THE VASCULAR WALL%REACTOME%R-HSA-202733.3 Cell surface interactions at the vascular wall Grb7 Amica1 Itga6 Tspan7 Pick1 Gp6 Angpt2 Itga3 Gas6 F11r Angpt4 Grb14 Dok2 Sell Apob Tnfrsf10b Yes1 Lyn Itgb2 Itgam Itgav Ppil2 Spn Jam2 Jam3 Slc3a2 Kras L1cam Slc7a5 Jchain Lck Ptpn6 Angpt1 Ptpn11 Itga5 Procr Itgb1 Pros1 Thbd Cd74 Nras Tek Mif Cd177 Pf4 Hras Proc Cd2 Selplg Cd84 Mertk Glg1 Cd99l2 Cd48 Sele Pik3cb Itgb3 Trem1 Slc7a6 Fyn Slc7a9 Slc7a8 Slc7a7 Inpp5d Esam Vpreb2 Fcamr Cav1 Cd244 Epcam Vpreb3 Gypc Pik3ca Slc16a3 Slc16a1 Bsg Slc16a8 F2 Slc7a10 Shc1 Fcer1g Slc7a11 Itga4 Selp Plcg1 Atp1b2 Sirpa Atp1b3 Itgal Atp1b1 Pecam1 Cxadr Ppia Sdc3 Mmp1a Sdc4 Sdc2 Sdc1 Tgfb1 Mag Itgax Fn1 Olr1 Sos1 Pik3r1 Cd44 Pik3r2 Cd47 Gpc1 VESICLE-MEDIATED TRANSPORT%REACTOME DATABASE ID RELEASE 59%5653656 Vesicle-mediated transport Myo6 Dvl2 Arpc5 Arpc4 Klc3 Klc2 Klc4 Racgap1 Ocrl Bloc1s4 Tbc1d8b Bloc1s3 Ap2m1 Bloc1s6 Vps25 Hspa8 Necap1 Acbd3 Hip1r Picalm Dtnbp1 Cpd Ap2a1 Pum1 Gak Gdi2 Gdi1 Ap2a2 Sh3gl2 Snf8 Vps36 Dnm2 Trip10 Klc1 Ap2s1 Dnm1 Cttn Arpc1a Als2cl Sbf1 Cops7b Sbf2 Cops7a Dennd5a Dennd5b Mon1a Mon1b Als2 Clta Ulk1 Ap2b1 Ankrd27 Dennd4a Dennd4b Cops8 Clint1 Tpd52l1 Kif4 Cltc Cops6 Sort1 Cops2 Snx2 Cops4 Ap3s1 Cops5 Sh3d19 Dnm3 Yipf6 Cops3 Snapin Fzd4 Itsn1 Snx9 Snx5 Ap3b1 Slc2a4 Pla2g4a Slc2a8 Optn Tbc1d24 Adrb2 Cux1 Ap4b1 Clvs1 Ap1g2 Hyou1 Ap1s2 Ap1b1 Scarf1 Ap1s1 Bloc1s1 Ap1g1 Dnajc6 Hsph1 Ap1s3 Ap4e1 Rab3a Vamp7 Syt1 Ap4s1 Vamp2 Clvs2 Txndc5 Ap4m1 Dnase2a Ap1m2 Gns Ap1m1 Rab33a Tsc2 Rab5c Rab5b Arrb2 Egfr Arrb1 Adrbk1 Rala Rab35 Agtr1a Cltb Golga4 Golga1 Stx18 Scoc Naa38 Rab3gap1 Naa30 Naa35 Arfip2 Rabepk Tmf1 Arl1 M6pr Rab9 Plin3 Igf2r Gcc1 Gcc2 Rab11b Chm Bicd2 Bicd1 Usp6nl Rab43 Pafah1b3 Pafah1b2 Apoe Vamp4 Rhobtb3 Rab39b Ywhab Chml Rab8b Rab7 Vps54 Cd3d Surf4 Rab9b Arfrp1 Avp Galnt1 Galnt2 Rab18 Avpr2 Cd4 Rint1 Gja3 Bnip1 Gja5 Rab6b Rab6a Gjb6 Vps52 Gjb5 Vps51 Cd3g Gja4 Use1 Gjc2 Vps53 Gapvd1 Pafah1b1 Egf Trappc11 Dennd6b Trappc12 Trappc13 Rab3il1 Dennd1b Dennd6a Rinl Dennd3 Ywhag Rabgef1 Stxbp3 Dennd1c Rab3ip Dennd4c Hsp90aa1 Trappc8 Hps1 Hps4 Rab8a Chrm2 Rin2 Rin3 Dennd2a Rin1 St5 Dennd1a Dennd2d Dennd2c Myo1c Rab11a Myh2 Csnk1d Dynll1 Sh3kbp1 Gjb1 Gjb2 Col4a2 Col4a1 Dync1i2 Dctn2 Alb Dctn3 Ywhaz Ywhah Sfn Rab27b Cftr Dync1h1 Pip5k1c Actr2 Actr3 Kif5a Kif5b Nedd8 Sparc Arpc3 Arpc2 Rhoq Adrbk2 Zw10 Prkaa2 Ywhae Slc18a3 Gjd2 Saa3 Pla2g6 Arf6 Col3a1 Hsp90b1 Fth1 Scgb3a2 Rab38 App Ftl1 Colec11 Colec12 Rac1 Marco Rab32 Rab31 Rab12 Rab13 Wasl Rab10 Scara5 Rab21 Col1a2 Wnt5a Col1a1 Apoa1 Cenpe Apob Msr1 Kif2c Vamp8 Kif2b Vamp3 Kif18a Stx4a Calr Tsc1 Kif2a Tjp1 Gga2 Tbc1d10c Tfrc Gga3 Trf Cd36 Jchain Snap23 Ambp Gja10 Cd163 Hpx Gjc1 Hp Eps15l1 Epn1 Gga1 Prkag2 Prkag1 Prkag3 Rab36 Snap29 Rgp1 Rab30 Rab33b Trip11 Stx16 Rab39 Myh4 Myh7 Myh6 Myh8 Aspscr1 Dab2 Necap2 Gpr21 C2cd5 Snap91 Syt11 Tbc1d10a Tbc1d10b Hip1 Myh1 Myh3 Syt9 Snx18 Rabgap1 Reps1 Sgip1 Myo5a Fcho2 Rab27a Fcho1 Fnbp1l Syt2 Reps2 Ston2 Exoc3 Exoc4 Akt2 Akt3 Exoc1 Exoc5 Exoc6 Exoc8 Exoc7 Exoc2 Ubc Prkab1 Lnpep Map1lc3b Tacr1 Stab2 Akt1 Stab1 Prkab2 Gjd3 Gjd4 Gja1 Gjb4 Gjb3 Gja8 Ldlrap1 Ldlr Lrp1 Trappc2 Tgfa Trappc3 Ins2 Mcfd2 Trappc1 Rab1 Hba-a1 F5 Preb Copa F8 Sec24a Sec24b Sptan1 Sec13 Tmed3 Sec24d Scfd1 Gria1 Sec24c Man2a1 Sh3gl1 Stam Hgs Arcn1 Tfg Ykt6 Stam2 Cd59b Eps15 Tbc1d15 Cog6 Chmp5 Tbc1d17 Lman2l Chmp7 D130043K22Rik Cog3 Chmp6 Chmp3 Sytl1 Cog4 Vps37d Tbc1d25 Cog2 Tbc1d14 Vps37c Sec31a Tbc1d13 Vps37b Tbc1d16 Cog1 Ctage5 Rab5a Myh15 Tonsl Gorasp1 Gabarapl2 Vps4b Kif3c Nsf Tor1b Vps4a Tor1a Trappc6a Vta1 Kif3b Myh13 Kif3a Chmp2a Pacsin3 Trappc6b Chmp4c Pacsin2 Chmp4b Pacsin1 Tmed9 Man1c1 Rabep1 Kif18b Ralgapb Bet1l Gabarap Gbf1 Epn2 Ankrd28 Fnbp1 Cbl Scarb2 Man1a Syt8 Trappc9 Aak1 Agfg1 Napb Vps37a Tbc1d7 Napg Ubqln2 Kifc5b Ubqln1 Kifc2 Tbc1d1 Napa Bin1 Trappc5 Tbc1d4 Spta1 Tbc1d2 Trappc4 Sptbn4 Dctn5 Dctn6 Cyth2 Kif16b Ctsz Kif26a Golim4 Dctn1 Serpina1d Itsn2 Col7a1 Amph Lman1l Cyth1 Dctn4 Areg Vti1a Stx6 Serpina1a Vps45 Golga5 Dync1li2 Kif26b Folr1 Cyth4 Cyth3 Dync1li1 Man1a2 Kif13b Alppl2 Ric1 Rab1b Kif20b Ppp6r1 Ppp6r3 Arf5 Cnih1 Kif20a Tsg101 Kdelr2 Synj2 Kdelr3 Uso1 Kifap3 Bet1 Stx17 Cnih3 Kif22 Ctsc Lrp2 Cnih2 Hbb-bt Kif27 Synj1 Cog7 Tmem115 Kif23 Cog8 Kif9 Arfgap3 Arfgap1 Arfgap2 Sar1b Kif12 Golgb1 Kif15 Copb2 Stx5a Kif19a Kif6 Kif1c Copb1 Pik3c2a Kif21a Ppp6c Kif21b Copz1 Hbb-bs Ank1 Ank3 Kif1b Sec23a Kif1a Copz2 Trappc10 Sec23ip Copg1 Gosr1 Golga2 Dynll2 Gosr2 Arf1 Kdelr1 Arf3 Arf4 Kif11 Dync1i1 Sptbn2 Trappc2l Sptbn1 Rab14 Tbc1d20 Cope Sec16b Sec22a Lman1 Sec22b Sptb Lman2 Sec16a Sec22c Rab4a Agpat3 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION%REACTOME%R-HSA-162658.1 Golgi Cisternae Pericentriolar Stack Reorganization Rab2a Ccnb2 Cdk1 Golga2 Uso1 Rab1 Gorasp2 Gorasp1 Plk1 Mapk1 Blzf1 Rab1b REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE%REACTOME%R-HSA-3371453.1 Regulation of HSF1-mediated heat shock response Nup85 Nup160 Nup50 Tpr Ywhae Ndc1 Nup214 Aaas Nup210 Nup188 Nup54 Nup35 Nupl2 Dnajb6 Nup62 l7Rn6 Hspa4 Nup205 Nup155 Hspa9 Nup88 Rps19bp1 Pom121 Rae1 Bag5 Dnajb1 Bag1 Hsf1 Dnajc7 Sirt1 Mapkapk2 Dnajc2 Nup93 Hspa12a Hspa12b Bag2 Nup153 Bag3 Ccar2 Hspa14 Hspa4l St13 Hspa13 Rpa2 Rpa1 Atm Nup107 Rpa3 Hspa1a Hspa2 Hspa1l Nup37 Hspa8 Nup43 Nup133 Bag4 Hspa5 Mapk3 Mapk1 Gsk3b Hsph1 Ranbp2 FGFR4 MUTANT RECEPTOR ACTIVATION%REACTOME DATABASE ID RELEASE 59%1839128 FGFR4 mutant receptor activation Fgfr4 MISSPLICED GSK3BETA MUTANTS STABILIZE BETA-CATENIN%REACTOME%R-HSA-5339716.2 Misspliced GSK3beta mutants stabilize beta-catenin Ppp2cb Ppp2r1b Apc Axin1 Ppp2ca Amer1 Csnk1a1 Ctnnb1 Gsk3b Ppp2r1a Ppp2r5b Ppp2r5e Ppp2r5c Ppp2r5d Ppp2r5a ADAPTIVE IMMUNE SYSTEM%REACTOME%R-HSA-1280218.3 Adaptive Immune System Ube2r2 Ube2q2 Prkcb Cybb Cyba Klc3 Klc2 Klc4 Mib2 Racgap1 Was Cul7 Ap2m1 Ube2e3 Ctsh Ap2a1 Ap2a2 Rnf123 Ctsa Sh3gl2 Itgav Dnm2 Klc1 Ap2s1 Dnm1 Clta Ap2b1 Kif4 Cltc Dnm3 Rapgef4 Rapgef3 Ncf4 Skp1a Ncf2 Csk Cd274 Ncf1 Cul1 Trem1 Cd300e Klrd1 Klrk1 Fbxl7 Fbxl18 Cd300lb Cd8b1 Cul5 Rnf41 Itch Wwp1 Nedd4 Ap1s2 Ap1b1 Ap1s1 Ap1g1 H2-Q10 Ap1s3 B2m Ap1m2 Ap1m1 Casp9 Tsc2 Pdgfrb Siah1a Pdgfra Mlst8 Kbtbd7 Vav1 Fbxw10 Trim21 Egfr Gab1 Mtor Phlpp1 Siah2 Phlpp2 Trim32 Rasgrp2 Rbx1 Cdkn1a Cul3 Psmd12 Pdgfb Psmd11 Keap1 Psmd14 Psmd13 Psmd10 Itgb2 Kit Ppp2r1b Cdc23 Ube2d1 Ywhab Ago2 Ago1 Cdc27 Tnrc6c Kras Cdc16 Cdc20 Insr Gsk3a Ube2c Rab7 Gsk3b Ube2e1 Tnrc6b Anapc7 Anapc4 Shfm1 Anapc5 Tnrc6a Anapc1 Ago4 Anapc2 Ago3 Itpr1 H2-Aa Cd3d Trat1 Cd3e Irs2 H2-Eb1 Mdm2 Park2 Lck Pten Pdcd1lg2 Hbegf Cd4 Ptpn6 Irs1 Btc Itpr3 Pdcd1 Ptpn11 Cd3g Itpr2 Trib3 Psmc6 Egf Fgf23 Psmc5 Pag1 Fgf22 Psmc2 Canx Fgf20 Psmd2 Prkacb Psmb9 Uba6 Psmb8 Hras Cd79b Ppp2r5e Malt1 Mapkap1 Card11 Cd79a Ppp2r5c Rps6kb2 Ppp2r5d Ppp2r5a Fbxw2 Psmc1 Psmc4 Fbxw5 Psmc3 Fbxw4 Pik3cb Fbxw9 Rnf111 Foxo3 Fbxw7 Anapc11 Pik3cd Anapc10 Foxo1 Fzr1 Fyn Stim1 Cd22 Creb1 Fcgr4 Trpc1 Orai1 Orai2 Dapp1 Rasgrp3 Plcg2 Blk Bcl10 Blnk Cblb Ppp2r5b Dynll1 Rasgrp1 Syk Ier3 Fcgr1 Sh3kbp1 Rel Nfkbie Pik3ca Cdkn1b Actr1a Prkaca Dync1i2 Nr4a1 Prr5 Hgf Dctn2 Pip5k1a Dctn3 Ereg Ywhaz C3 Rap1a Btk Rap1b Hspa5 Fgfr4 Dync1h1 Psma5 Ube2d3 Psma4 Psma3 Psma6 Akt1s1 Psma2 Psma1 Pip5k1b Cd19 Evl Pip5k1c Psmd9 Fgf16 Ctss Fgf15 Kif5a Klb Kif5b Smurf1 Ctsb Fgf18 Ctsk Ube2g2 Them4 Ctsl Psmd1 Ube2g1 Stub1 Met Ctsd Psmd3 Psmd4 Itgb5 Pdpk1 Psmd6 Psmd5 Pik3r3 Psmd7 Ube2l3 Uba1 Pik3r1 Psmd8 Fgf10 Pik3r2 Ube2b Amica1 Slamf6 Slamf7 Ube2a Lmo7 Rchy1 Rap1gap2 Lrrc41 Rap1gap Rlim Ppp2r1a Hace1 Ube2l6 Sipa1 Btrc Fbxo4 Nfkb1 Ptprj Cd101 Fbxo6 Fbxw11 Zap70 Arih2 Ptpn22 Rnf34 Myd88 Lat Osbpl1a Cd200 Xdh Cd207 Map3k7 Znrf1 Dtx3l Cdc34 Rac1 Tab2 Cd226 Pak1 Ripk2 Arel1 Map3k8 Rela Rnf217 Uba7 Rnf213 Sell Nfkbia Nedd4l Rnf220 Nfkbib Ctla4 Lonrf1 Ppl Cenpe Cd86 Kif2c Mrc2 H2-M3 Mrc1 H2-M5 Vamp8 Sec61a2 Kif2b Uba3 Vamp3 Kif18a Rnf144b Atg7 H2-Q1 Stx4a Calr Tapbp Tlr2 Sh2d1a Tlr6 Map3k14 Trim41 Sec61g Cd80 Sec61a1 Kif2a Sec61b Pdia3 Hectd3 Cul2 Hectd1 Icam1 Hectd2 Ube2o Ube2f Npepps Ube3a Ube3c Ube2m Ube3b Cd40lg Ube2z Hcst Ube2w H2-DMa Ube2k Lrr1 Ube2h Lair1 Ubox5 Cd36 Snap23 Tap1 Tap2 Tnfrsf14 Vhl Tlr1 Tirap Fbxl5 Fbxl3 Vprbp Oscar Crtam Frs2 Cd74 Nras Gan Hecw2 Psmf1 Traf7 Cd81 Raf1 Psme4 Ube2v2 Fgf1 Cd8a Bad Fcgr2b Fgf2 Kctd7 Kctd6 Traip Erbb2 Fgf9 Skp2 Fgf7 Treml4 Psme3 Ncr1 Fgf6 Treml2 Fgf4 Ifi30 Treml1 Fgf3 Rnf4 Cd96 Tpp2 Mill2 Blmh Huwe1 Ccnf Kbtbd13 Trim69 Btn1a1 Sh3rf1 Btla Det1 Trim71 Ctse Ltn1 Ctsf Ctso Asb18 Asb11 Trim63 Asb16 Asb17 Asb14 Sh2d1b1 Asb12 Asb13 Trim39 Trim50 Trim36 Asb15 Trim37 Cd200r1 Ppp2cb Fbxw8 Fbxl16 Cd300lf Srms Chuk Fbxl19 Siglec1 Nrg2 Fbxl14 Cd300lg Ppp2ca Fbxl13 Fbxl15 Nrg1 Fbxl12 Mex3c Fbxl8 Akt2 Akt3 Itga4 Psma7 Fbxl4 Siglecg Plcg1 Siglece Psmb5 Fbxo7 Psmb4 Fbxo9 Zbtb16 Ubc Nrg3 Itgb7 Psmb7 Klhl2 Nrg4 Itgal Psmb6 Klhl9 Psmb2 H2-Oa Psmb3 Klhl20 H2-Ob Psmb1 Klhl22 Klhl21 Fbxo2 Nck1 Cxadr Lnpep Mapk3 Akt1 Trim11 Mapk1 Klhl25 Trim9 Herc2 Klhl13 Klhl11 Pip4k2b Lrsam1 Pja2 Pip4k2a Trp53 Vcam1 Pja1 Rbck1 Pip4k2c AF251705 Tceb1 Pik3ap1 Btn2a2 Spsb1 Psme2 Ubr2 Ubr1 Psme1 Spsb4 Trip12 Mkrn1 Ubr4 Sos1 Herc1 Rictor Herc3 Ubac1 Psmb10 Herc4 Actr1b Cd1d2 Spsb2 Icosl Anapc13 Ahcyl1 Fbxl21 Smurf2 Psmb11 Fbxl20 Grap2 Herc6 Itk Klhl41 Lcp2 Klhl42 Mov10 Ins2 Sec24a Sec24b Sec13 Sec24d Sec24c Lgmn Sec31a Kif3c Kif3b Kif3a Yes1 Lyn Prkcq Cbl Ufl1 Socs1 Ube4a Rnf126 Lilra5 Rnf115 Ptprc Dctn5 Dctn6 Kif26a Dctn1 Traf6 Ikbkb Trem2 Dctn4 Ube2v1 Tlr4 Ube2n Dync1li2 Ly96 Pak3 Cd14 Dync1li1 Pak2 Ikbkg Kif20a Kifap3 Kif22 Ctsc Kif23 Sar1b Itgb1 Kif15 Kbtbd8 Rnf7 Cd300a Sec23a Rnf6 Klrg1 Btnl9 Btnl2 Icam4 Icam5 Dynll2 Arf1 Dzip3 Ube2q1 Kif11 Cd160 Dync1i1 Mgrn1 Sptbn2 Lag3 Rnf130 Rnf138 Ube2e2 Inpp5d Rnf114 Lnx1 Mylip Rnf19a Rnf19b H2-DMb2 Sec22b Rnf182 Klrb1 Cd209a Klrc1 Fbxo30 Icam2 Fbxo32 Fbxo31 Cdh1 Btbd6 Btbd1 Fbxo27 Erap1 Fbxo22 Fbxo21 Uba5 Tyrobp Rilp Socs3 Fyb Fbxo10 Ube2cbp Fbxo17 Asb5 Asb4 Rnf14 Asb3 Asb2 Pvrl2 Asb1 Asb9 Vasp Asb7 Asb6 Fbxo40 Wsb1 Rnf25 Ube2j1 Asb8 Ube2j2 Fbxo44 Fbxo41 INTEGRATION OF PROVIRUS%REACTOME DATABASE ID RELEASE 59%162592 Integration of provirus Lig4 Psip1 Xrcc5 Banf1 Xrcc6 Xrcc4 Hmga1 Kpna1 Ppia VITAMINS%REACTOME%R-HSA-211916.1 Vitamins Cyp24a1 Cyp2r1 Cyp26c1 Cyp26a1 Cyp27b1 Cyp26b1 NEF AND SIGNAL TRANSDUCTION%REACTOME%R-HSA-164944.2 Nef and signal transduction Hck Fyn Lck Rac1 Elmo1 Dock2 Pak2 EXTENSION OF TELOMERES%REACTOME%R-HSA-180786.1 Extension of Telomeres Dkc1 Nhp2 Wrap53 Tert Pcna Ruvbl2 Ruvbl1 Rfc5 Rfc3 Rfc2 Rfc4 Rfc1 Pole Dna2 Pold1 Pold2 Pold3 Pold4 Prim1 Pole2 Rpa2 Rpa1 Rpa3 Pola1 Pola2 Lig1 Fen1 Pole4 Prim2 Pole3 TRNA PROCESSING%REACTOME DATABASE ID RELEASE 59%72306 tRNA processing Trdmt1 Trp53rkb Nup85 Rpp21 Nup160 Trmt112 Rpp25 Tsen54 Fam98b Nsun6 Elac2 Gtpbp3 Trmt10a Trmt10c Nsun2 Qtrtd1 Mto1 Trmt13 Trmt12 Trmt11 Tyw1 Alkbh8 Lcmt2 Qtrt1 2700060E02Rik Rtcb Tyw3 Tyw5 Nup107 Dus2 Nup37 Adat2 Pus3 Nup43 Mettl1 Nup133 Adat1 Pus7 Ftsj1 Trmt1 Tsen34 Pop4 Pop1 Pop7 Pop5 Tsen15 1110008L16Rik Xpot Ctu2 Trit1 Ctu1 Tsen2 Zbtb8os Wdr4 Trmt5 Ddx1 Urm1 Ranbp2 Nup50 Tpr Ndc1 Nup214 Aaas Nup210 Nup188 Nup54 Nup35 Nupl2 Nup62 Nup205 Nup155 Nup88 Trmu Pom121 Trnt1 Rae1 6430573F11Rik Nup93 Nup153 Cpsf1 Clp1 Ran Trmt44 Tprkb Osgep Cstf2 Cpsf4 Rpp14 Eprs Cdkal1 Rpp30 Rpp38 AI597479 Trmt61a Thg1l Hsd17b10 Rpp40 THE NLRP3 INFLAMMASOME%REACTOME DATABASE ID RELEASE 59%844456 The NLRP3 inflammasome P2rx7 Txn1 App Pstpip1 Hsp90ab1 Pycard Casp1 Nlrp3 Txnip Mefv Panx1 Sugt1